bluuebunny/crossref_metadata_2025 huggingface dataset:
MLL methyltransferases regulate H3K4 methylation to ensure CENP-A assembly at human centromeres
Authors: Malik Kausika Kumar , Sridhara Sreerama Chaitanya , Lone Kaisar Ahmad , Katariya Payal Deepakbhai , Pulimamidi Deepshika , Tyagi Shweta
Published: June 2023

The active state of centromeres is epigenetically defined by the presence of CENP-A interspersed with histone H3 nucleosomes. While the importance of dimethylation of H3K4 for centromeric transcription has been highlighted in various studies, the identity of the enzyme(s) depositing these marks on the centromere is still unknown. The MLL (KMT2) family plays a crucial role in RNA polymerase II (Pol II)-mediated gene regulation by methylating H3K4. Here, we report that MLL methyltransferases regulate transcription of human centromeres. CRISPR-mediated down-regulation of MLL causes loss of H3K4me2, resulting in an altered epigenetic chromatin state of the centromeres. Intriguingly, our results reveal that loss of MLL, but not SETD1A, increases co-transcriptional R-loop formation, and Pol II accumulation at the centromeres. Finally, we report that the presence of MLL and SETD1A is crucial for kinetochore maintenance. Altogether, our data reveal a novel molecular framework where both the H3K4 methylation mark and the methyltransferases regulate stability and identity of the centromere.
The plasma separation card as a novel solution for enhancing central laboratory capability for HIV-1 viral load monitoring in limited-access settings
Authors: Kiyaga Charles , Makoha Caroline , Nkugwa Ivan , Okiira Christopher , Okwir Richard , Gebreab Sirak Zenebe , Suarez Patricia Rodriguez-Ventosa , LaBrot Benjamin , Durán Ana Carrasco
Published: June 2023

Measurement of HIV-1 viral load (VL) is essential for monitoring antiretroviral treatment (ART) efficacy. The preferred specimen type for VL is plasma, but in remote settings where collection and preservation of plasma many not be possible, dried blood spots (DBS) are often used instead. A new specimen collection matrix, the cobas plasma separation card (PSC, Roche Diagnostics Solutions), enables specimen preparation from a finger prick or venous blood, using a multi-layer absorption and filtration design that results in a specimen similar to dried plasma. We sought to confirm the correlation between VL results obtained using PSC prepared from venous blood to those from plasma or DBS, as well as PSC prepared with capillary blood from a finger prick. PSC, DBS and plasma were prepared with blood from HIV-1 infected persons attending a primary care clinic in Kampala, Uganda. VL in PSC and plasma was measured using cobas HIV-1 (Roche Diagnostics), while VL in DBS was measured with RealTime HIV-1 (Abbott Diagnostics). The correlation between VL from plasma and PSC made from capillary or venous blood was high (regression coefficient of determination r2 between 0.87 and 0.91), and there was good agreement based on mean bias (-0.14 to 0.24 log10 copies/mL) and classification of VL above or below 1000 copies/mL (91.4% agreement). In contrast, VL from DBS was lower than plasma or PSC (mean bias 0.51 to 0.63 log10 copies/mL) and not as well correlated (r2 0.78 to 0.81, 75.1–80.5% agreement). These results confirm the utility of PSC as an alternative specimen type for HIV-1 viral load measurement in areas where preparation and optimal storage or shipment of plasma is an obstacle to provision of treatment and care of HIV-1 infected people.
SARS-CoV-2 seroprevalence on the north coast of Peru: A cross-sectional study after the first wave
Authors: Moyano Luz M. , Toledo Angie K. , Chirinos Jenny , Vilchez Barreto Percy Mc Quen , Cavalcanti Sofia , Gamboa Ricardo , Ypanaque Jhon , Meza Mauro , Noriega Sheilla , Herrera Victor , Bazan Edgar , Requena Alexandra , Silva Henry , Burgos Harold , León-Jimenez Franco ,   Group of Neuroepidemiology and Science of Life of Peru
Published: June 2023

Background

Peru had the second-highest number of COVID-19 cases in Latin America. After the first wave, Peru registered more than 900,000 cases of COVID-19 and more than 36,000 confirmed deaths from the disease. Tumbes, a border area with poor sanitation and not enough water, had the fifth highest death rate. The cross-sectional analytic study aimed: a) to assess seroprevalence of COVID-19 after the first wave; b) to assess sociodemographic determinants and symptoms associated with a positive COVID-19 antibody lateral flow test.

Methodology/principal findings

We performed this study between November 11th and November 30th, 2020, in an informal settlement in Tumbes. Individuals older than two years were invited to participate in a systematic random sample from one in every four households. Finger-prick blood samples were collected, and a census and symptom survey were applied. Within the chosen house, one adult over 18 years of age was chosen for a PCR-RT molecular test. Overall seroprevalence was 25.59%, adjusted seroprevalence was 24.82% (95%CI 22.49–27.25). Women had higher adjusted seroprevalence (28.03% vs 21.11%; 95% CI 24.83–31.41, p = 0.002). Symptoms as fever (PR 1.89: 95% CI 1.44–2.48, p<0.001), general discomfort (PR 1.67; 95% CI 1.23–2.26, p = 0.001), cough (PR 2.0; 95% CI 1.60–2.50, p<0.001), nasal congestion (PR 1.46; 95% CI 1.03–2.09, p = 0.036), respiratory distress (PR 1.64; 95% CI 1.04–2.56, p = 0.031), headache (PR 1.54; 95% CI 1.09–2.17, p = 0.014), anosmia (PR 1.78; 95% CI 1.01–3.14, p = 0.046) and ageusia (PR 2.31; 95% CI 1.48–3.61, p<0.001) were associated with a positive covid-19 antibody lateral flow test.

Conclusions/significance

The COVID-19 transmission and distribution were highlighted by this cross-sectional study. The data will help the Ministry of Health improve its monitoring, surveillance, and monitoring of respiratory community sequelae in the future.
Timing of invasive mechanical ventilation and death in critically ill adults with COVID-19: A multicenter cohort study
Authors: Green Adam , Rachoin Jean-Sebastien , Schorr Christa , Dellinger Phil , Casey Jonathan D. , Park Isabel , Gupta Shruti , Baron Rebecca M. , Shaefi Shahzad , Hunter Krystal , Leaf David E. ,   for the STOP-COVID Investigators
Published: June 2023

Purpose

To investigate if the timing of initiation of invasive mechanical ventilation (IMV) for critically ill patients with COVID-19 is associated with mortality.

Materials and methods

The data for this study were derived from a multicenter cohort study of critically ill adults with COVID-19 admitted to ICUs at 68 hospitals across the US from March 1 to July 1, 2020. We examined the association between early (ICU days 1–2) versus late (ICU days 3–7) initiation of IMV and time-to-death. Patients were followed until the first of hospital discharge, death, or 90 days. We adjusted for confounding using a multivariable Cox model.

Results

Among the 1879 patients included in this analysis (1199 male [63.8%]; median age, 63 [IQR, 53–72] years), 1526 (81.2%) initiated IMV early and 353 (18.8%) initiated IMV late. A total of 644 of the 1526 patients (42.2%) in the early IMV group died, and 180 of the 353 (51.0%) in the late IMV group died (adjusted HR 0.77 [95% CI, 0.65–0.93]).

Conclusions

In critically ill adults with respiratory failure from COVID-19, early compared to late initiation of IMV is associated with reduced mortality.
Friendship habits questionnaire: A measure of group- versus dyadic-oriented socializing styles
Authors: Howlett Philip , Baysu Gülseli , Atkinson Anthony P. , Jungert Tomas , Rychlowska Magdalena
Published: June 2023

Friendships are central to our social lives, yet little is known about individual differences associated with the number of friends people enjoy spending time with. Here we present the Friendship Habits Questionnaire (FHQ), a new scale of group versus dyadic-oriented friendship styles. Three studies investigated the psychometric properties of group-oriented friendships and the relevant individual differences. The initially developed questionnaire measured individual differences in extraversion as well as desire for intimacy, competitiveness, and group identification, traits that previous research links with socializing in groups versus one-to-one friendships. In three validation studies involving more than 800 participants (353 men, age M = 25.76) and using principal and confirmatory factor analyses, we found that the structure of the FHQ is best described with four dimensions: extraversion, intimacy, positive group identification, and negative group identification. Therefore, competitiveness was dropped from the final version of the FHQ. Moreover, FHQ scores reliably predicted the size of friendship groups in which people enjoy socializing, suggesting good construct validity. Together, our results document individual differences in pursuing group versus dyadic-oriented friendships and provide a new tool for measuring such differences.
Creating building-level, three-dimensional digital models of historic urban neighborhoods from Sanborn Fire Insurance maps using machine learning
Authors: Lin Yue , Li Jialin , Porr Adam , Logan Gerika , Xiao Ningchuan , Miller Harvey J.
Published: June 2023

Sanborn Fire Insurance maps contain a wealth of building-level information about U.S. cities dating back to the late 19th century. They are a valuable resource for studying changes in urban environments, such as the legacy of urban highway construction and urban renewal in the 20th century. However, it is a challenge to automatically extract the building-level information effectively and efficiently from Sanborn maps because of the large number of map entities and the lack of appropriate computational methods to detect these entities. This paper contributes to a scalable workflow that utilizes machine learning to identify building footprints and associated properties on Sanborn maps. This information can be effectively applied to create 3D visualization of historic urban neighborhoods and inform urban changes. We demonstrate our methods using Sanborn maps for two neighborhoods in Columbus, Ohio, USA that were bisected by highway construction in the 1960s. Quantitative and visual analysis of the results suggest high accuracy of the extracted building-level information, with an F-1 score of 0.9 for building footprints and construction materials, and over 0.7 for building utilizations and numbers of stories. We also illustrate how to visualize pre-highway neighborhoods.
Using unofficial media, less trusting of Chinese polity?—An analysis based on the moderated mediation effect
Authors: Hu Qian , Pu Yanping
Published: June 2023

Enhancing political trust is an important manifestation of China’s ability to modernisation national governance in the media age. In the context where unofficial media has a crowding-out effect on official media, building political trust effectively becomes an important foundation for promoting the construction of a national governance system. This study employs the 2015 survey data on social consciousness of netizens and constructs a moderated mediation model using the bootstrap method, with subjective well-being as the intermediary variable and official media use as the moderating variable, to empirically explore the influence of unofficial media use on political trust and its underlying mechanism. The results reveal that unofficial media use significantly and steadily deconstructing political trust. In terms of the mechanism of transmission, subjective well-being is an important channel used by unofficial media use to deconstruct political trust, official media has a positive moderating role in the impact pathway of subjective well-being on political trust. Further research finds that unofficial media use has a stronger impact on trust in the central government, court, and police, compared to trust in township governments. Weibo or online communities and overseas media can deconstruct political trust, however, gossip or chatting with friends can construct political trust. In general, this study provides theoretical basis and empirical experience for how to enhance government trust and ultimately promote the construction of national governance system, given the increasing influence of unofficial media. Meanwhile, the research results also provide some reference value for countries with similar backgrounds to China.
Helping first-time mothers establish and maintain breastfeeding: Access to someone who can provide breastfeeding advice is an important factor
Authors: Massare Brittany A. , Hackman Nicole M. , Sznajder Kristin K. , Kjerulff Kristen H.
Published: June 2023

Background and aims

First-time mothers often need help with breastfeeding and may feel isolated and uncertain about whom they can turn to for help with breastfeeding challenges. Exploration of whether access to breastfeeding advice helps new mothers initiate and continue breastfeeding is necessary. This study investigated the associations between ease of access to breastfeeding advice for first-time mothers and breastfeeding initiation and duration.

Methods

This was a prospective, longitudinal cohort study of 3,006 women who delivered their first child in Pennsylvania, USA; with prenatal and postpartum interviews. At 1-month postpartum participants reported the extent to which they had access to “Someone to give you advice about breastfeeding if you needed it”, via a 5-point scale ranging from “none of the time” to “all of the time”.

Results

There were 132 women (4.4%) who reported that they had access to someone to give them advice about breastfeeding “none of the time”; 697 (23.3%) reported access “a little of the time” or “some of the time”; and 2,167 (72.3%) reported access “most of the time” or “all of the time”. While the majority of the new mothers were breastfeeding at 1-month postpartum (72.5%), less than half were still breastfeeding at 6-months postpartum (44.5%). The higher the level of access to advice about breastfeeding the more likely women were to establish breastfeeding by 1-month postpartum and to still be breastfeeding at 6-months.

Conclusions

For first-time mothers, ease of access to someone who can give them advice about breastfeeding facilitates breastfeeding establishment and continuation.
Interference mitigation in intentional jammers aided non-uniform heterogeneous cellular networks
Authors: Ghonaim Saleh Mohammed , Khan Samar , Althobiani Faisal , Alghaffari Shadi , Khan Sheraz , Irfan Muhammad , Haroon Muhammad Sajid , Muhammad Fazal
Published: June 2023

Coverage and capacity are optimized in fifth generation (5G) networks by small base station (SBS) distribution in the coverage realm of macro base station (MBS). However, system performance is significantly reduced by inter-cell interference (ICI) because of the orthogonal frequency division multiple access assumption. In addition to ICI, this work considers intentional jammers’ interference (IJI) due to the presence of jammers. These Jammers try to inject undesirable energies into the legitimate communication band, which significantly degrade uplink (UL) signal-to-interference ratio (SIR). To reduce ICI and IJI, in this work, we employ SBS muting, where the SBSs near MBS are switched off. To further mitigate ICI and IJI, we use one of the effective interference management schemes a.k.a reverse frequency allocation (RFA). We presume that due to mitigation in ICI and IJI, the UL coverage performance of the proposed network model can be further improved.
Intra and inter-rater repeatability of brachial artery ultrasound estimates of flow-mediated slowing and flow-mediated dilation
Authors: Marôco João Luís , Silvestre Tiago , Arrais Inês , Pinto Marco , Santa-Clara Helena , Fernhall Bo , Melo Xavier
Published: June 2023

Flow-mediated slowing (FMS) is a non-invasive measure of endothelial function measured through reactive hyperemia-induced changes in pulse wave velocity (PWV). FMS is suggested to mitigate known pitfalls of flow-mediated dilation (FMD) including suboptimal repeatability and high-operator dependency. However, the few single-rater studies that examined FMS repeatability have shown controversial results and used only regional measurements of PWV, which might not reflect local brachial artery stiffness responses to reactive hyperemia. We assessed the inter- and intra-rater repeatability of ultrasound-based changes in local PWV (FMS) and diameter (FMD). Twenty-four healthy male participants aged 23–75 yr, were examined on two separate days. Reactive hyperemia-induced changes in PWV were calculated using a tailored R-script. The inter- and intra-rater repeatability were tested with the intraclass correlation coefficient (ICC), coefficient of variation (CV), and the Bland-Altman plot estimates. The inter-rater repeatability of FMS (bias: -0.08%; ICC: 0.85; 95% CI: 0.65 to 0.93; CV: 11%) and FMD (bias: -0.02%; ICC: 0.98; 95% CI: 0.97 to 0.99; CV: 7%) showed overall good repeatability over different days. The intra-rater repeatability of FMD (1st rater: bias: 0.27%; ICC: 0.90; 95% CI: 0.78 to 0.96; CV: 14%; 2nd rater: bias: 0.60%; ICC: 0.85; 95% CI: 0.64 to 0.94; CV: 18%) was better than FMS (1st rater: bias: -1.03%; ICC: 0.76; 95% CI: 0.44 to 0.91; CV: 21%; 2nd rater: bias:-0.49%; ICC: 0.70; 95% CI: 0.34 to 0.80; CV: 23%) but not different between raters. Ultrasound-based local measurements of PWV deceleration reactive hyperemia were repeatable among the raters.
‘Experiences of patients and their informal caregivers with cognitive stimulation programs for dementia: A qualitative systematic review protocol’
Authors: Ryan Simone M. , Chockalingam Manigandan , Brady Orla
Published: June 2023

Introduction

Cognitive stimulation, an individual or group intervention approach aiming to improve cognitive and social functioning among individuals with mild-to-moderate dementia, is often considered a complex intervention. The patient’s experience of a complex intervention is unique and often determines its effectiveness. This proposed qualitative systematic review aims to comprehensively synthesise the experiences of individuals with dementia and their informal caregivers who have participated in cognitive stimulation programs, identifying perceived benefits, challenges, barriers, and facilitators to this approach to intervention.

Methods

This review will consider qualitative studies that evaluate the experiences of individuals with a diagnosis of dementia and/or the informal caregivers of individuals with dementia who have participated in a cognitive stimulation program. Searches will be conducted across MEDLINE (Ovid), Embase (Elsevier), PsycINFO, Scopus, CINAHL (EBSCO) and Web of Science. Quality of eligible studies will be assessed using the JBI Critical Appraisal Checklist for Qualitative Research, and a standardised data extraction tool in JBI SUMARI will be used to extract data from relevant studies. The meta-aggregation approach will be used to pool qualitative research findings, which will then be synthesised to produce a single set of findings in narrative format.

Discussion

This qualitative systematic review will identify and synthesise the evidence regarding the experiences of individuals with dementia who have taken part in a cognitive stimulation program and the experience of their informal caregivers. As a variety of cognitive stimulation programs exist, our findings will summarise the experiences of these interventions to inform the future development and delivery of cognitive stimulation programs.

Trial registration

PROSPERO registration number: CRD42022383658.
Feasibility and clinical usefulness of deep learning-accelerated MRI for acute painful fracture patients wearing a splint: A prospective comparative study
Authors: Roh Seunghyeon , Park Jae In , Kim Gun Young , Yoo Hye Jin , Nickel Dominik , Koerzdoerfer Gregor , Sung JaeKon , Oh Jiseon , Chae Hee Dong , Hong Sung Hwan , Choi Ja-Young
Published: June 2023

Objective

To evaluate the feasibility and clinical usefulness of deep learning (DL)-accelerated turbo spin echo (TSEDL) sequences relative to standard TSE sequences (TSES) for acute radius fracture patients wearing a splint.

Methods

This prospective consecutive study investigated 50 patients’ preoperative wrist MRI scans acquired between July 2021 and January 2022. Examinations were performed at 3 Tesla MRI with body array coils due to the wrist splint. Besides TSES obtained according to the routine protocol, TSEDL sequences for axial T2-, coronal T1-, and coronal PD-weighted TSE sequences were scanned for comparison. For quantitative assessment, the relative signal-to-noise ratio (rSNR), the relative contrast-to-noise ratio (rCNR), and the relative contrast ratio (rCR) were measured. For qualitative assessment, all images were assessed by two independent musculoskeletal radiologists in terms of perceived SNR, image contrast, image sharpness, artifacts disturbing evaluation, overall image quality and diagnostic confidence for injuries using a four- or five-point Likert scale.

Results

The scan time was shortened approximately by a factor of two for TSEDL compared to TSES. TSEDL images showed significantly better rSNR, rCNR, and rCR values for all sequences, and scored significantly better in terms of both image quality and diagnostic confidence for both readers than TSES images (all p < .05). Interrater reliabilities were in almost perfect agreement.

Conclusion

The DL-accelerated technique proved to be very helpful not only to reduce scan time but also to improve image quality for acute painful fracture patients wearing a splint despite using body array coils instead of a wrist-specific coil. Based on our study, the DL-accelerated technique can be very useful for MRI of any part of the extremities in trauma settings just with body array coils.
Two mutually exclusive evolutionary scenarios for allexiviruses that overcome host RNA silencing and autophagy by regulating viral CRP expression
Authors: Kim Hangil , Kawakubo Shusuke , Takahashi Haruna , Masuta Chikara
Published: June 2023

The genusAllexiviruscurrently includes eight virus species that infect allium plants. Previously, we showed that there are two distinct groups of allexiviruses (deletion [D]-type and insertion [I]-type) based on the presence or absence of a 10- to 20-base insert (IS) between the coat protein (CP) and cysteine rich protein (CRP) genes. In the present study of CRPs to analyze their functions, we postulated that evolution of allexiviruses may have been largely directed by CRPs and thus proposed two evolutionary scenarios for allexiviruses based mainly on the presence or absence of IS and determined by how the allexiviruses challenge host resistance mechanisms (RNA silencing and autophagy). We found that both CP and CRP are RNA silencing suppressors (RSS), that they can inhibit each other’s RSS activity in the cytoplasm, and that CRP becomes a target of host autophagy in the cytoplasm but not CP. To mitigate CRP interference with CP, and to increase the CP’s RSS activity, allexiviruses developed two strategies: confinement of D-type CRP in the nucleus and degradation of I-type CRP by autophagy in the cytoplasm. Here, we demonstrate that viruses of the same genus achieve two completely different evolutionary scenarios by controlling expression and subcellular localization of CRP.
‘She would probably envy herself, from outside’: Auto-fictional narrations in Alice Munro’s ‘Fiction’
Authors: Disney Dan
Published: June 2023

In one of Alice Munro’s longer stories, the metafictional ‘Fiction’, readers encounter a series of contingent narratives in which characters exert explicit, self-constructing expressive labours. The text is split into two sections: in the first, the protagonist Joyce is betrayed by her husband, Jon and her life momentarily falls to pieces. In the second section, decades later, Joyce is remarried, surrounded by friends and family, her life replenished and thriving. A gamut of fictions suffuses this text, as if Munro’s scenes are case studies delivering heuristic knowledge and Joyce’s self-narrativizations act as if a generative mode of self-care (the talking cure for one, as such). At heart, Munro seems to explore for the possible functions of fiction: through Joyce’s example, it seems that part of the work of fiction remains intra-personal, in this text a means by which to switch trauma off. Joyce’s mind is shown to work in anti-repressive modes, creating clearly narrativized lines of self-understanding which, in this case, enable the protagonist to literally come to terms with a self-told story placing at the denouement her own blamelessness. Herewith, ‘Fiction’ can be read as a complexly woven narrative on modes of narrativization, Munro seemingly implying that memories retold and reframed are a functional gestalt enabling some to become more than the sum of past traumas. Through accepting that life sometimes can be as positively strange as fiction, Joyce is able finally to both rejoice and (as it were) re-Joyce.
Boundaries and Connections. Producing, organizing and sharing knowledge on medieval Iberian art
Authors: Cavero Alicia Miguélez
Published: June 2023

To what extent and how are today's increasingly interconnected and porous real and virtual worlds conditioning and even determining research in Art History? Several art historians have pointed out that, as the globe becomes hyper-connected, the discipline is shifting its focus from local and national questions to global or worldwide issues. This paper aims to analyze this shift in the historiography of medieval Iberian art. I argue that research is indeed being reshaped by the removal or the crossing of physical, epistemic and virtual boundaries as well as by pushing forth an increasing interest in connectivity. Additionally, I propose to cross or remove surviving rigid boundaries still further, to construct more flexible and fluid epistemic limits, and to establish additional connections at several levels.
O casamento de Mariana Vitória e de Gregório, ou o «defeito do mulatismo»
Authors: Monteiro Nuno Gonçalo
Published: June 2023

A história que se vai contar apoia-se sobretudo em fontes judiciais e refere-se ao contexto imediatamente subsequente à publicação da legislação pombalina da última fase. Datado de 1781/1783, constitui um dos casos nos quais filhos solteiros menores de 25 anos pretenderam casar-se contra a vontade dos seus pais ou tutores que deram lugar a processos que subiram à Mesa Desembargo do Paço e resultaram numa consulta. O caso em análise destaca-se pela singularidade dos argumentos invocados e debatidos, em particular, acerca do «defeito de mulatismo». A consulta final da mesa do supremo tribunal do reino, favorável aos nubentes e depois assinada pelo monarca, permite sugerir que, no reino de Portugal e Algarves (onde se aplicava o  Alvará de 1773), não só se proibia classificar alguém como liberto, como tal inibição era explicitamente equiparada à supressão  jurídica do preceito de «mulatismo», assimilando-se a condição de liberto à de mulato.
Deuses africanos e santos cristãos nas Américas
Authors: Thornton John
Published: June 2023

Ao abordar as maneiras pela quais as tradições religiosas africanas transitaram pelo Atlântico durante o tráfico de cativos, este artigo enfatiza uma abordagem teológica da religião africana. As tradições religiosas africanas geralmente têm figuras espirituais de caráter local: ancestrais, divindades territorialmente delimitadas e entidades espirituais menores. As principais exceções se encontram em áreas como Angola, onde divindades cristãs foram descobertas na África; e as áreas de língua Gbe (no Togo, Benin e Nigéria), onde algumas divindades não foram definidas territorialmente. Embora geralmente divindades africanas não pudessem atravessar o oceano, as técnicas de localização de entidades espirituais por revelação contínua o fizeram, e assim novas divindades foram localizadas no Brasil. Para muitos africanos no Brasil, os santos católicos conhecidos em Angola tornaram-se foco de adoração e propiciação no Brasil; e há evidências documentais de que a revelação contínua no Brasil permitiu que as divindades da área de língua gbe também transitassem pelo oceano, resultando nos estágios iniciais do desenvolvimento do candomblé.
Effect of Drumstick leaves on prevention of anemia among adolescent girls in low and middle income countries
Authors: Rasaily Sushma
Published: June 2023

Iron deficiency Anemia (IDA) is one of the serious health problems prevailing across the globe. It is estimated that about 1.62 billion population are affected all over the world. The prevalence of anemia is seen more among adolescent girls and pregnant women. Some of the important causes of anemia are low dietary intake, iron losses due to menstrual period and several other factors with many serious consequences. One of the major consequences of IDA is the reduction in hemoglobin level in the body and other medical complications associated with it. Therefore, management of anemia is of a major concern and can be done through consumption of locally available, low cost and underutilized fruits and vegetables rich in iron, vitamin A and vitamin C etc. For e.g. drumsticks leaves are rich source of iron found locally and effective in combating anemia yet still underutilized.
Kontestasi Narasi Perempuan Dalam Website Islam: Analisis Perbandingan Mubadallah.id dan Muslimah.News
Authors: Andani Meri , Romario Romario
Published: June 2023

Artikel ini mengkaji narasi perempuan yang diproduksi oleh website Islam. Website telah menjadi sumber informasi sekaligus pengetahuan dalam memahami Islam. Salah satu isu yang menjadi sorotan dalam website Islam adalah persoalan perempuan. Penelitian ini mengambil website Mubalah.id dan Muslimahnews.com sebagai perbandingan dalam melihat narasi perempuan di website. Penelitian ini memetakan isu perempuan yang terdapat dalam website Mubadalah.id dan Muslimahnews.com. Hasil penelitian ini menunjukan bahwa narasi perempuan dalam Mubadalah.id berisikan informasi dan narasi yang berupaya membuat perempuan setara, serta aktif terlibat dalam mengambil keputusan dan berisikan pesan moderat, sebaliknya dalam Muslimahnews.com, narasi perempuan seringkali menjadi subodinat dan kepatuhan, disisi lain Muslimahnews.com selalu menyampaikan bahwa Syariat Islam adalah solusi atas permasalahan perempuan. Kedua Website ini menunjukan bagaimana narasi perempuan digambarkan dalam dua sudut pandang yang berbeda, hal ini tidak lepas dari aflisiai Mubadalah.id dan Muslimahnews.com.
[This article examines women’s narratives produced by Islamic websites. The website has become a source of information as well as knowledge in understanding Islam. One of the issues in the spotlight on Islamic websites is the issue of women. This study takes the websites Mubalah.id and Muslimahnews.com as a comparison in viewing women’s narratives on the website. This study maps women’s issues contained in the websites Mubdalam. id and Muslimahnews.com. The results of this study indicate that the women’s narrative in Mubidah.id contains information and narratives that seek to make women equal, and is actively involved in making decisions and contains moderate messages, on the contrary in Muslimahnews.com, women’s narratives are oftensubordinated and obedient, on the other hand, Muslimahnews. com always conveys that Islamic Shari’a is the solution to women’s problems. These two websites show how women’s narratives are described in two different perspectives, this cannot be separated from the affiliates of Mubidah.id and Muslimahnews.com.]
Uszy Karenina, paznokcie Hryniewicza
Authors: Kraskowska Ewa
Published: June 2023

Artykuł dotyczy obecności i funkcji detali korporalnych w Annie Kareninie Lwa Tołstoja. Przez detal korporalny rozumie się tu pojedynczy fragment ludzkiej zewnętrzności cielesnej (np. ucho, dłoń, palec, paznokieć, kark, łydkę, kosmyk włosów) postrzegany przez postacie ze świata przedstawionego utworu i/lub przez auktorialnego narratora. Istotnym punktem odniesienia dla analiz i interpretacji przeprowadzonych w artykule jest styl lektury proponowany przez Vladimira Nabokova w jego akademickich wykładach o literaturze oraz przedstawiona przez Kazimierza Bartoszyńskiego teoria lektury wielokrotnej.
W stronę afektu
Authors: Buryła Sławomir
Published: June 2023

Artykuł omawia monografię Marka Zaleskiego Intensywność i rzeczy pokrewne (Warszawa 2022). Recenzowana książka napisana jest stylem balansującym między dyskursem naukowym a wypowiedzią charakterystyczną dla poetyki eseju. Jej autor ciekawie analizuje w kilkunastu tekstach kategorię intensywności oraz pokrewne jej pojęcia pamięci zbiorowej, pamięci indywidualnej. Badacz, omawiając problemy najnowszej prozy polskiej, sięga po ustalenia najnowszej humanistyki.
Head or tail? A molecular dynamics approach to the complex structure of TNF-associated factor TRAF2
Authors: Erba Fulvio , Di Paola Luisa , Di Venere Almerinda , Mastrangelo Eloise , Cossu Federica , Mei Giampiero , Minicozzi Velia
Published: June 2023

Tumor necrosis factor receptor-associated factor proteins (TRAFs) are trimeric proteins that play a fundamental role in signaling, acting as intermediaries between the tumor necrosis factor (TNF) receptors and the proteins that transmit the downstream signal. The monomeric subunits of all the TRAF family members share a common tridimensional structure: a C-terminal globular domain and a long coiled-coil tail characterizing the N-terminal section. In this study, the dependence of the TRAF2 dynamics on the length of its tail was analyzed in silico. In particular, we used the available crystallographic structure of a C-terminal fragment of TRAF2 (168 out of 501 a.a.), TRAF2-C, and that of a longer construct, addressed as TRAF2-plus, that we have re-constructed using the AlphaFold2 code. The results indicate that the longer N-terminal tail of TRAF2-plus has a strong influence on the dynamics of the globular regions in the protein C-terminal head. In fact, the quaternary interactions among the TRAF2-C subunits change asymmetrically in time, while the movements of TRAF2-plus monomers are rather limited and more ordered than those of the shorter construct. Such findings shed a new light on the dynamics of TRAF subunits and on the protein mechanism in vivo, since TRAF monomer–trimer equilibrium is crucial for several reasons (receptor recognition, membrane binding, hetero-oligomerization).
Understanding the characteristics of loess strata and quaternary climate changes in Luochuan, Shaanxi Province, China, through core analysis
Authors: Guo Jiao , Shi Jiansheng , Song Chao , Dong Qiuyao , Wang Wei
Published: June 2023

Profile sampling, which causes missing or overlapping horizons, has been generally used while studying loess stratigraphy and paleoclimate. Conversely, drill sampling of thick loess can provide a relatively complete and actual record of the Quaternary climate and environmental changes. Here, paleomagnetic chronological analysis and particle size and magnetic susceptibility analyses were performed to accurately reveal the loess stratigraphy characteristics of Luochuan loess tableland in Fu County, Shaanxi Province, China. The FX core revealed that the Quaternary loess layer was 167.03 m thick and consisted of 33 layers of developed loess/paleosol sequences and 37 loess/paleosol assemblages. The paleosol horizons indicated relatively warm and humid climatic period, while loess/sand reflected cold and arid climate. Since 2.6 Ma, the climate of the region has undergone 37 warm and cold cycles trending toward an increasingly dry and cold climate. During this time, 10 paleoclimate cycles occurred during 2.6–1.6 Ma, 15 climate cycles occurred during 1.6–0.8 Ma, and 12 loess–paleosol cycles have occurred from 0.8 Ma to the present day. Our study provides a basis for accurately and comprehensively interpreting the paleoclimate and paleoenvironment during loess deposition formation.
Leveraging of mycogenic copper oxide nanostructures for disease management of Alternaria blight of Brassica juncea
Authors: Gaba Swati , Prasad Lakshman , Varma Ajit , Rai Ashutosh Kumar , Prasad Ram , Goel Arti
Published: June 2023

Brassica is one of the crops sensitive to low copper supply, leading to Alternaria blight. The present study reflects the synthesis of myco-derived copper oxide (M-CuO) nanoparticles (NPs) from Trichoderma asperellum and investigates their effect against Alternaria blight of Brassica in two soil types, alluvial and calcareous. Foliar applications of different treatments were used to treat plants: T1 (mancozeb@0.2%), T2 (propiconazole@0.05%), T3 (T. asperellum filtrate), T4 (M-CuO NPs), T5 chemically synthesized (C-CuO NPs), and T6 bulk phase (BP-CuO @25, 50, 100, 150, and 200 ppm) of each in twice such as protectant and curative method under pot experiments. M-CuO NPs in two protective sprays exhibit up to 75% disease suppression in alluvial soil, compared to 68.9% suppression in curative spray at 200 ppm. Maximum seed yield and seed number were obtained, 1.95 g/plant and 850 seeds/plant in alluvial soil, but in calcareous soil, seed yield (1.14 g/plant) and seed number 414 seeds/plant were recorded in plants supplemented with M-CuO NPs as a protectant. In both soils, maximum plant height was increased by protective applications of M-CuO NPs at 200 ppm. Thus, the present study suggested that among foliar sprays of copper nanocompounds, protective activity shows better results as compared to curative activity. Among all the treatments, M-CuO NPs were found to be most effective in suppressing disease and improving productivity and growth-promoting effects of Brassica.
Double Impact: A Macroeconomic Study of the Crossed Influences Between Climate Change and Business Tourism
Authors: Kayal Mohamed
Published: June 2023

International tourism is a main sector of economy that witnesses continuous and tremendous growth in developed and developing countries and expresses destabilization by several factors including climate change. Being considered as a sensitive sector to climate, tourism shows, through several criteria such as number of arrivals and receipts, an influence by environmental and socioeconomic modifications. This article will outline the interrelationships between climate change phenomenon and the business component of the international tourism. Three focal elements that were developed through literature on the effects of climate change for tourism will be critically reviewed: climate change and temporal shifts in tourism demand, climate-inducted change and destination competitiveness within the major market segment of business tourism, and future tourist mobility. The review will develop the differential weakness of tourism destinations and the consequence in competitiveness that will transform some international markets. This will be relevant to explain why destinations will need to adapt to the risks and opportunities posed by climate change. Despite several elements illustrating progress in the past years, an important gap of knowledge in each of the major impact areas needs to be looked into in order to indicate to the concerned tourist the necessity for a well preparation toward challenges of climate change.
Das Hienrecht – ein unbekannter Begriff der mittelalterlichen Rechtssprache
Authors: Deter Gerhard
Published: June 2023

The legal term “Hienrecht” corresponds legally to one law of living in bondage, which was widespread in north-western Germany in the Middle Ages. It has not been considered by legal history. The Hien (bondsmen) were – according to the etymological findings – members of the same household: some kind of tenants, then also the serfs of a grange. In Westphalia, the dependent farming population can be roughly divided into Hofhörige (corresponds approximately bondsmen), Eigenbehörige (some kind of serfdom) and members ofthe household/inmates. Hienrecht had its place within the framework of these different orders. On the one hand, the term Hien was associated with a certain form of serfdom, but on the other hand it could also refer to the persons in charge of the property. The Hienrecht described a specific legal and property form of the Unterhof of a villication, namely that of the Liten. In the late Middle Ages Hienrecht meant one of the legal relationships of bondage, then to be found in Westphalia, in particular probably that of Eigenbehörigkeit. Hienrecht referred to the sub-ownership of the rural tenants equipped with secured inheritance rights, which were composed in a Villication or a modified form of the same cooperative.
Guarino Guarini and the Understanding of Space and Place in Early Modern Architectural Theory
Authors: Mitrović Branko
Published: June 2023

The philosophical treatise Placita philosophica, composed by the seventeenth-century architect Guarino Guarini, presents a comprehensive discussion of the concepts of space, place, ubication (location), and infinity, drawing upon the Aristotelian tradition and formulated within the arguments defined by a series of Counter-Reformation authors identified as the second (or baroque) scholasticism. This study analyzes the significance of these views for Guarini’s architectural theory.
Introduction
Authors: Li Yifei , Zinda John Aloysius
Published: June 2023

Debates about authoritarian environmentalism need a firmer grounding in actually existing authoritarian environmental projects. The articles in this issue look across multiple dimensions of authoritarian environmental governance in East Asia to trace its contours and contingencies. We sum up the resulting insights in seven theses: Authoritarian environmental governance is not new. Evaluating outcomes is crucial—and fraught. We need to specify the “authoritarian” in authoritarian environmental governance. We need to recognize the breadth of environmental governance. Regimes differ from one another. Regimes change over time. And regimes work within the world-system. We need to be clear-eyed about how authoritarian regimes undertake environmental governance: attentive to its multifarious real-world manifestations and their practical and moral implications. To do this requires great care in assessing what is necessary and what is contingent in authoritarian environmental governance, and why.
RENDERING SERVICES IN CHILD AND YOUTH CARE CENTRES: EXPERIENCES AND CHALLENGES OF SOCIAL WORKERS
Authors: Phaswana Kagisho , Erlank Elizabeth
Published: June 2023

Effective social work services in child and youth care centres (CYCCs) depend on how social workers deal with the associated experiences and challenges. This study explored social workers’ experiences and challenges in rendering services in CYCCs in the Tshwane municipal district. A qualitative research approach employing the phenomenological design was adopted, and in-depth semi-structured interviews were conducted. The findings confirmed that social workers have various positive and negative experiences and face multiple challenges in rendering services in CYCCs. Several suggestions to improve service delivery in CYCCs are made. Keywords: social worker, experiences, challenges, social work services, Child and Youth Care Centre (CYCC)
As carpideiras rituais egípcias: entre a expressão de emoções e a encenação pública. A importância das lamentações fúnebres
Authors: Das Candeias Sales José
Published: June 2023

ResumoIconograficamente, o tema das carpideiras rituais egípcias como componente das práticas religiosas do antigo Egipto está particularmente bem atestada, sobretudo a partir da XVIII Dinastia, em baixos-relevos e pinturas parietais e tumulares, em pinturas em papiros, em estatuetas e em estelas. A importância ritual das lamentações públicas das carpideiras e dos carpideiros egípcios é sublinhada pelo arquétipo simbólico-mitológico da lenda osiriana, em que as irmãs divinas Ísis e Néftis se lamentam sobre o corpo morto de Osíris. A evolução religiosa egípcia fez do morto vulgar um Osíris divino, necesitando do mesmo zelo e cuidado das lamentações fúnebres. Da gramática de posturas perfeitamente estereotipadas e codificadas observáveis nas representações artísticas egípcias merece especial destaque o papel desempenhado pelos braços, pelas mãos, pela cabeça e pelos cabelos. Entre estes últimos, salienta-se o gesto nwn: as carpideiras atiravam o cabelo para a cara, tapando os olhos e simbolizando assim a obscuridade da morte. A teatralidade da dor assim encenada recebe na cultura egípcia uma dupla função, social (expressão social das emoções) e simbólica (expressão metafísica das lamentações), e faz da temática das lamentações uma das mais importantes dinâmicas da ideologia da morte no Egipto antigo.Palavras-chave: Carpideiras, lamentações fúnebres, teatralidade, iconografia.ResumenIconográficamente, el tema de las plañideras rituales egipcias como un componente de las prácticas religiosas del antiguo Egipto está particularmente bien documentado, sobre todo desde la dinastía XVIII, en bajorrelieves y pinturas parietales y de tumbas, pinturas en papiro, en estatuillas y en estelas. La importancia ritual de las lamentaciones públicas de las plañideras y de los plañideros egipcios se ve subrayada por el arquetipo simbólico y mitológico de la leyenda de Osiris, en el que las hermanas divinas Isis y Neftis lloran sobre el cadáver de Osiris. La evolución religiosa egipcia hizo de lo muerto ordinario un Osiris divino, que requiere el mismo celo y cuidado de las lamentaciones fúnebres. En la gramática de posturas perfectamente estereotipadas y codificadas observables en representaciones artísticas egipcias merece una mención especial el papel desempeñado por los brazos, las manos, la cabeza y el pelo. Entre estos últimos, se observa el gesto nwn: las plañideras lanzaban el pelo en la cara, cubriendo sus ojos, lo que simbolizaba la oscuridad de la muerte. La teatralidad del dolor así escenificada recibe en la cultura egipcia una doble función, social (expresión social de las emociones) y simbólica (expresión metafísica de las lamentaciones), y hace del tema de las lamentaciones una de las más importantes dinámicas de la ideología de la muerte en el antiguo Egipto.Palabras clave: Plañideras, lamentos fúnebres, teatralidad, iconografía.
Aida, el Canal de Suez y su inauguración. Ópera en tres actos, epílogo y adenda
Authors: Escribano Martín Fernando
Published: June 2023

El 17 de noviembre de 1869 se inauguró el Canal de Suez en una ceremonia presidida por la emperatriz de los franceses, Eugenia de Montijo. Como parte de los fastos para celebrar tan magno acontecimiento, el jedive de Egipto había previsto también inaugurar el teatro de la ópera construido al efecto con una obra encargada a Verdi: Aida. Este estreno se retrasó dos años, y en el intervalo Francia había sido derrotada por el Imperio alemán y quedaba ya poco de aquel esplendor que había permitido imponer la construcción del canal pese a las reticencias británicas. La ópera y el canal permanecen, y los dos tienen aún hoy un papel importante. En esta comunicación se pretende, además de mostrar la gestación de ambas obras, reflexionar sobre el papel del historiador o del creador de una obra artística en la transmisión del pasado que se puede llevar a cabo por distintos intereses.Palabras clave: Aida, Egiptología, Canal de Suez, Eugenia de Montijo.AbstractOn November 17, 1869 was inaugurated the Suez Canal in a ceremony presided by French Empress Eugenia de Montijo. As part of the pageantry to celebrate this great event, the Khedive of Egypt had also planned to inaugurate the opera house purposed built with a work commissioned to Verdi: Aida. This premiere was delayed two years, and in the interval France had been defeated by the German Empire and has already losed the splendor which had allowed imposing the canal construction despite British reluctance. The opera and the channel remain, and both have an important role even today. In this communication, in addition to show the gestation of both works, we want to reflect on the role of the historian or the creator of an artistic work in the transmission of the past that can be carried out by different interests intended.Keywords: Aida, Egyptology, Suez Canal, Eugénie de Montijo.