bluuebunny/crossref_metadata_2025 huggingface dataset:
The logical thinking abilities of high school students in relation to their cognitive development stage
Authors: Rakhmawan Aditya
Published: December 2024

Logical thinking is an essential skill for students’ academic success, particularly in science and mathematics. This study seeks to examine high school students' logical thinking abilities in relation to their cognitive development stage, based on Piaget's theory of cognitive development. The research uses a non-experimental design in the form of a survey. The survey sample included 219 eleventh-grade high school students from Ketapang, West Borneo, selected using cluster random sampling as the sampling method. The survey data collection utilized a two-tier method developed by Tobin and Capie (1981). The result of this research is as much as 11.71% of student were in last formal stage, 22.93% of student were in first formal stage, 30,73% of students were in trantitional stage, and 34.63% of students were in concrete stage.
Analysis of Teacher Readiness in Implementing Learning Based on Local Maritime Potential
Authors: Siregar Eko Febri Syahputra , Sarkity Dios , Fernando Adam , Pratama Yudi , Intasir M. Pemberdi
Published: December 2024

Learning is an important part of education. The quality of learning largely determines achievement of educational goals. Learning needs to be integrated with the environment to prepare students according to the needs of the times. The expected impact is that students will be aware of the environment, have a sense of ownership, and keep it sustainable. This research was carried out to determine teacher readiness in implementing learning based on local maritime potential. The type of research is descriptive qualitative with the subject being elementary school teachers at State 013 Tanjungpinang City. Data sources were obtained through interviews, observation and collection of learning documents. Based on the data obtained, teachers are ready to integrate learning based on local maritime potential. This can be seen from the learning activities carried out as well as the documentation of the devices available. Then, teachers routinely carry out learning using technology to increase interest and motivation. Teachers also encounter obstacles and challenges regarding insight that needs to be improved regarding local potential because teachers are not native residents and their abilities. Several recommendations are also given to overcome the problems that emerged in this research.
Tradition of Criticizing Antiques on Full Moon Nights: Local Wisdom Heritage of Lingga Regency
Authors: Lexminander Lexminander , Mariono Mariono , Syafitriandy Syafitriandy , Bambang Bambang , Zaitun Zaitun
Published: December 2024

This study aims to understand more deeply the symbolic meaning, religious value and social value of the Tradition of Criticizing Antiques on Full Moon Nights, as an effort to preserve ancestral heritage in the midst of modernization. The tradition of criticizing antiques on full moon nights is a form of local wisdom of the Lingga community, which is rich in historical and spiritual values. This ritual is carried out every full moon, aiming to honor heirlooms that have mystical powers and ancestral heritage. Antiques are taken out and assessed by the community, this tradition is called “criticizing the Full Moon” which is the time when natural energy and the supernatural world reach their peak, this ritual is a means of communicating with the universe and maintaining spiritual balance. The study used a qualitative case study approach, data was collected through in- depth interviews, participatory observation and literature studies. In terms of case studies, this tradition is carried out in Lingga Regency, precisely in the Capital City of Daik Lingga. The results of the study show that the tradition of criticizing antiques on full moon nights contains symbolic meaning and has religious value. This ritual strengthens social relations in the community and emphasizes local cultural identity.
Air Circulation Drying Technology: Entrepreneurial Strategy for the Tamban Fish Crackers Industry
Authors: Fitrinaldi Fitrinaldi , Sarianty Feby , Sitanggang Sarmian , Fathussalamiah Fathussalamiah , Abdulhajar Encik , Zaitun Zaitun
Published: December 2024

This research evaluates the use of drying technology with air circulation to improve the production efficiency of tamban fish crackers. This research uses a quantitative experimental design to evaluate the efficiency of drying technology with air circulation compared to traditional drying methods. The research results show that this technology is able to reduce drying time from 7 hours to 5 hours resulting in more consistent product quality in terms of moisture and texture. This technology has operational flexibility and does not depend on weather conditions, so production can be carried out throughout the year. Drying technology with air circulation offers an effective solution to increase the productivity and competitiveness of the tamban fish cracker industry.
College Students Practice on Sustainable Development Goals: A Study About Environmental Sustainability in Coastal Area
Authors: Sarkity Dios , Fernando Adam , Pratama Yudi , Intasir M. Pemberdi , Siregar Eko Febri Syahputra
Published: December 2024

The Sustainable Development Goals (SDGs) agenda until 2030 is a shared concern and responsibility, including universities. The extent to which universities have made efforts to realize the SDGs can be seen from the level of student practice in realizing the SDGs, one of which is related to a sustainable environment. The purpose of this study was to measure the level of student practice related to environmental sustainability. The study was conducted in October 2024 at Universitas Maritim Raja Ali Haji, Indonesia, involving 223 Biology Education Students. This study is a descriptive study with a quantitative approach. The data collection techniques and instruments used were questionnaires. The data were analyzed using descriptive methods. Overall, the level of student practice related to environmental sustainability is in enough category. These results indicate the need for action from universities to increase the level of student practice in efforts to realize the SDGs, including those related to a sustainable environment. Efforts can be made in the form of integrating SDGs into the curriculum or in various programs and projects involving students.
Analysis of community knowledge and understanding in terms of age level regarding the condition of the mangrove ecosystem in Tanjung Unggat Village, Tanjungpinang City
Authors: Nevrita Nevrita , Nurjanah Tri Wahyuni , Purba Erika , Ananda Erdi , Novianti Marsha , Afriana Dina
Published: December 2024

Mangrove ecosystems are an integral part of coastal ecosystems and have several ecological and economic benefits. However, the community's understanding of the mangrove ecosystem is still very shallow. This research aims to explore the Tanjung Unggat community's knowledge of the condition of the mangrove ecosystem. Data was collected through interviews and qualitative questionnaires. The method used is a simple qualitative method. The sampling technique is random sampling. Data collection using questionnaires and interviews. Research Results From the results of questionnaires that have been distributed to communities around the mangrove ecosystem, 33.33% of people aged 17-25 have knowledge of the mangrove ecosystem, while 23.67% of people aged 26-34 have knowledge, and 17 % aged 35-48 have the same knowledge about the mangrove ecosystem
The influence of chemistry learning attitudes in coastal areas on understanding of knowledge related to climate change
Authors: Sabekti Ardi Widhia , Fitriani Rita , Umara Yudi
Published: December 2024

Climate change has become a global threat, especially for coastal areas. Prospective chemistry teachers in coastal areas must have a deep understanding of climate change because of their strategic role. It has never been investigated before how attitudes toward learning chemistry in coastal regions affect understanding about climate change. This study looked at how attitudes toward learning chemistry in coastal areas affected students' understanding of climate change. The participants consisted of 77 chemistry teacher candidates from a maritime university in Indonesia. Data was collected using the ALCh Instrument and the Climate Change Concept Inventory (CCCI). Simple linear regression analysis results indicated a significant effect of chemistry learning attitudes on understanding related to climate change (sig. 0.018 < 0.05). Additionally, the findings revealed that positive attitudes towards learning chemistry positively influenced the understanding of climate change, with a regression coefficient of 1.518 and R Square of 0.072.
How do UMRAH biology teacher candidate students behave regarding the existence of green technology products?
Authors: Fernando Adam , Fitri Rima Hersya
Published: December 2024

Awareness of green technology products has now increased. However, the success of its implementation is highly dependent on the attitudes and behaviour of the community, especially prospective biology teacher students at the Raja Ali Haji Maritime University (UMRAH) as someone who will build a society in the future. This study aims to determine the behaviour of prospective biology teacher students at UMRAH toward the existence of green technology products that are currently circulating. This descriptive study involved 76 new students of the UMRAH Biology Education Study Program in the last two years (2023-2024). Data were obtained using a questionnaire and analyzed on average per item. Based on the results of the research and discussion obtained, prospective biology teacher students at UMRAH behave well toward the existence of green technology products.
Development of Teaching Materials for Descriptive Texts with Pancasila Student Profile Value and Local Wisdom of Madurese Islands Community for Junior High School Students
Authors: Setyawan Arief , Syarifudin Albitar Septian
Published: December 2024

This study aims to describe the development of descriptive text teaching materials in Indonesian language materials that contain Pancasila learner profile values and local wisdom of the Madurese community in the archipelago. The values of the Pancasila learner profile are based on the noble character of 1) faith, devotion to God Almighty, and noble character, 2) independence, 3) mutual cooperation, 4) global diversity, 5) critical reasoning, and 6) creativity. Meanwhile, the value of local wisdom of the Madurese archipelago is defined as everything from outlook on life, science, to life strategies developed and held firmly by the Madurese archipelago. This research is a type of Research and Development (RnD) with 4D development techniques, namely define, design, develop, and disseminate. The feasibility analysis of teaching materials received an average of 89,50% from validators with a very feasible category. This shows that the teaching materials developed were declared “Very Feasible” to be used in the learning process. Teachers can utilize this teaching material as a means of strengthening student character and fostering their love for the diverse values of local wisdom, especially those of the Madurese community in the islands.
Isti Learn To Read With The Acrostic Mnemonic Technique
Authors: Kurmalasar Tety , Suryaningsih Suryaningsih , Atmadinata Atmadinata , Komalasari Rika , Mariono Mariono , Herianto Bambang , Hidayat Taufik , Suharyanto Suharyanto , Susanto Alpino , Hakim Yusuf
Published: December 2024

The Education plays a very important role in advancing and shaping the character of the nation's children. This research is based on the problems of communication difficulties, social difficulties and behavioral disorders in autistic children so that learning to read the acrostic mnemonic technique is one method that can reduce the problems that autistic children face. This acrostic mnemonic technique is applied by combining the first few letters of the word that will be put together to form an interesting word. The method used in this research uses a qualitative approach with action studies connected between acrostic mnemonics, planning, implementation, observation and reflection. From the results of this research, it is possible to train reading for an autistic child named (Isti) using the acrostic mnemonic technique, namely by recognizing vowels correctly, recognizing consonant letters correctly, recognizing diphthong letters, understanding the concept of one open vowel sound, understanding the concept of one vowel sound. closed, understand the concept of two vowel sounds, understand the concept of three vowel sounds, read syllables in speech and read quickly so that this process runs optimally and can be remembered well.
Understanding of Interculturalism and Inclusiveness in the Living Environment of UMRAH Student
Authors: Yani Wa Yuri , Putri Helmalia , Fitria Fitria , Selpiani Seila
Published: December 2024

The research is motivated by observation data which shows the results of cultural analysis in the UMRAH environment. To respond to this, researchers conducted research aimed at increasing cultural understanding in the UMRAH environment. The method used is qualitative by distributing questionnaires and interviews. And from the results of the questionnaire it can be concluded that 56% of students understand and understand that knowledge of intercultural understanding and inclusiveness.
Project-based Learning Task Design: Designing Mathematical Literacy Learning Program for High School in Tanjungpinang, Riau Islands
Authors: Astuti Puji , Febrian Febrian
Published: December 2024

This design-based research focuses on designing a project-based learning activities carried out in one semester for the Mathematical Literacy course in 2023/2024 academic year in the Mathematics Education Study Program at Raja Ali Haji Maritime University. This one cycle research enables us to design, test, and revise our materials. The teaching experiment is conducted for pre-service teachers who enrol the course enhancing their mathematical literacy understanding by engaging in a project to design a program which integrates mathematical literacy into high school mathematics lesson in Tanjungpinang. The key feature of our design is making sense of phenomena of mathematical literacy and designing solutions to problems. The project task consists of four key activities: defining problems through literature analysis where pre-service students explore relevant literature of mathematical literacy and conduct field needs analysis which includes interview with mathematics teacher, classroom observations, and administering mathematical literacy test to students; designing the project administering the field analysis, finishing the project through active discussion with lecturer and peers, and conducting evaluation. This project task results observation instruments, picture of mathematical literacy of high school students’ in high schools in Tanjungpinang, and a learning design to integrate mathematical literacy for mathematics lesson.
Creating Digital Media-Based Content as Output of Project-Based Learning: Exploring Students' Perspectives on Implementation, Challenges, and Solutions
Authors: Nuzulia Rahma , Nopita Dewi , Subroto Gatot , Pohan Erwin , Abdul Hajar Encik , Satria Benni
Published: December 2024

Given the emphasis on case or team-based projects as the crucial performance indicators in syllabus, lecturers from Raja Ali Haji Maritime University have designed a syllabus that promote digital media content creation as the project output to support society 5.0 and environmental awareness in the context of language learning. This study explores the perspectives of second-semester English students who participated in creating digital media-based content that included maritime context as their group-project in vocabulary building course. This study applied an exploratory descriptive-qualitative design. Data were collected from questionnaires, focus-group interviews and observation. The data were collected, thematically categorized, and interpreted. Findings revealed that two types of digital media were created in the course: a Canva-based E-Book and a website-based learning reference. Most students perceived the implementation of creating digital media-based content positively. However, challenges such as vocabulary limitations, skill gaps, communication issues, and self-adjustment were encountered during the project. Additionally, metacognitive strategies such as planning, information management strategies, monitoring, debugging strategies and evaluation are utilized by the students throughout the project.
Perspektive von Pflegefachpersonen zur Entwicklung spezifisch
pflegerischer Aufgabenprofile in der Endoskopie – eine qualitative
Erhebung
Authors: Lescrinier Julia
Published: December 2024

Hintergrund Vor dem Hintergrund pflegerischer
Professionalisierungsprozesse in der Endoskopie wird die Perspektive von
Pflegefachpersonen im Hinblick auf ihr Pflegeverständnis und ihre Vorstellungen
zur Entwicklung spezifisch pflegerischer Aufgabenprofile untersucht.

Methode Für diese qualitative Studie werden 9 leitfadengestützte
Interviews mit fachweitergebildeten Pflegefachpersonen durchgeführt. Nach der
Transkription erfolgte eine Datenanalyse mittels inhaltlich strukturierender
qualitativer Inhaltsanalyse nach Kuckartz und Rädiker.

Ergebnisse Das Pflegeverständnis der Pflegefachpersonen wird durch eine
ganzheitliche Versorgung der Patient*innen mit besonderem Augenmerk auf die
Beziehungsgestaltung, Interessensvertretung und Gewährleistung der
Patientensicherheit geprägt. Als zentrale Vorstellung zur Entwicklung spezifisch
pflegerischer Tätigkeiten wird die Implementierung des präendoskopischen
Pflegegesprächs identifiziert. Zudem wird die Optimierung verschiedener
pflegerischer Prophylaxen als notwendig erachtet. Die Übernahme ärztlicher
Tätigkeiten spielt eine untergeordnete Rolle, während die Behebung zahlreicher
entwicklungshemmender Alltagsbarrieren als vordringlich angesehen wird.

Schlussfolgerungen Für die Entwicklung eines eigenständigen Handlungsfelds
der Endoskopiepflege sind ein professionelles Pflege- und Berufsverständnis
sowie eine feste Verankerung spezifisch pflegerischer Tätigkeiten in den
Berufsalltag zwingend erforderlich. Darüber hinaus sind Reformen und gesetzliche
Anpassungen erforderlich, um die notwendigen Rahmenbedingungen zu schaffen.
PSMA – Targeted Clinical Molecular Imaging of Atherosclerosis: Correlation with Cardiovascular Risk Factors
Authors: Baude Julia K. , Mottaghy Felix M. , Derlin Thorsten , Fischer Alexander , Heinzel Alexander , Bucerius Jan
Published: December 2024

Aim The early diagnosis of atherosclerotic changes to prevent ischemic events represents a clinical challenge.

Prostate-specific membrane antigen (PSMA) as an established diagnostic in the field of prostate cancer also appears to detect neovascularization and inflammation in other diseases. We hypothesized that it might be also suited for detection of inflammation in atherosclerosis.

Methods We analyzed data of 78 prostate cancer patients who received a PSMA ligand PET/CT for re-staging. The cardiovascular risk factors (CVRF) of each patient were documented. Target-to-background-ratios (TBR) were calculated from the individual uptake values for three different sections of thoracic aorta [ascending (AA) and descending aorta (AD), aortic arch (AoAC)]. Statistical analyses included a linear regression analysis with the PSMA ligand uptake values of the different arterial segments versus different CVRF as independent variables.

Results The meanTBRmax was measured highest in the AoAC (1.66 ± 0.33) compared to both other vessel sections (AA: 1.46 ± 0.21, p=0.001; AD: 1.59 ± 0.41, p=0.371). There was a correlation between the PSMA ligand uptake in all measured segments of the aorta and BMI, but only a significant correlation in the ascending aorta (r=0.347, p=0.001). This was confirmed in a subgroup analysis, which showed significantly higher uptake values in preadiposity (BMI >25) and obesity (BMI >30) patients in the ascending aorta (p=0.048).

Conclusion PSMA ligand uptake in the ascending aorta was linked to BMI. PET detection of vascular PSMA ligand uptake may be indicative of vessel wall inflammation to some extent. However, PSMA ligands appear to be less suitable than other tracers for this purpose, given their absent correlation with most established CVRFs.
Depression und Bewegung
Authors: Huber Gerhard
Published: December 2024

Depressive Erkrankungen liegen mit weitem Abstand an der Spitze der Fallzahlen in
der Psychiatrie und Psychosomatik. Psychische Störungen, bei denen Depressionen
eine zentrale Rolle spielen, sind mit mehr als 40 % für Erwerbsminderungsrenten
verantwortlich. Allerdings handelt sich hier nicht um ein homogenes
Indikationsgebiet, sondern zeigt in Ätiologie und Symptomatik eine weitaus
größere Varianz auf als die somatischen Krankheitsbilder.

Obwohl schon seit mehr als 50 Jahren Erfahrungen und Forschungsarbeit zu den
Potenzialen der Bewegungstherapie vorliegen, nimmt in Deutschland die Thematik
erst in den letzten Monaten erheblich an Fahrt auf, wie unter anderem die
Beiträge in diesem Heft zeigen. Hier soll nun gezeigt werden, dass solche
Störungen sehr vielfältige Entstehungsbedingungen aufweisen, die zu einer
komplexen Psychopathologie führen. Es ist deshalb für die Weiterentwicklung der
Bewegungstherapie angemessen, diese ätiologischen Modellvorstellungen
aufzugreifen und zur Grundlage einer differenzierten bewegungstherapeutischen
Behandlungsstrategie zu machen.
KI-basierte Prozessplanung in Notaufnahmen: Optimaler Ressourceneinsatz mit Reinforcement Learning
Authors: Otten Hubert , Thirunavukkarasu Thenuja , Tetz Lukas , Roos Dirk , Sirin Semih
Published: December 2024

Die Hochschule Niederrhein entwickelt im Innovationsprojekt „NotPASS“ ein Echtzeit-Planungssystem für den optimalen Ressourceneinsatz in der Notaufnahme. Hierbei werden mit Hilfe eines Algorithmus des bestärkenden Lernens (Reinforcement Learning, RL) Fachpersonal entlastet, Behandlungsabläufe verbessert und Wartezeiten von Patienten verkürzt.
Ernüchterung vermeiden: Verhaltenskodex Nachhaltigkeit
Authors: Schlüchtermann Jörg
Published: December 2024

Ein Verhaltenskodex bietet die Möglichkeit für die gesamte Klinikbelegschaft die Umweltauswirkungen eines Krankenhauses zu reduzieren. Sensibilisierung und Schulungen sind dabei ein Teil der Maßnahmen.
Kliniken im grünen Wandel: Wie die Industrie Krankenhäuser in ihren Nachhaltigkeitszielen unterstützen kann
Authors: Khalili Mina Negar , Ringel Merle
Published: December 2024

Die Reise zu einem nachhaltigen Gesundheitswesen ist herausfordernd, aber notwendig. Kliniken und Industrie müssen gemeinsam innovative Wege gehen, um nachhaltigere Lösungen zu entwickeln. Der Schutz von Patienten und Umweltverantwortung gehen dabei Hand in Hand für eine grünere Zukunft im Gesundheitswesen.
Optimierung: Nachhaltigkeits-Potenzial-Check für ein Krankenhaus-Versorgungszentrum
Authors: Gerhardt Malin , Raida Andrea
Published: December 2024

Um sowohl den ökologischen Fußabdruck zu reduzieren als auch der sozialen Verantwortung von Krankenhäusern gerecht zu werden, lohnt es sich die Logistikprozesse in den Versorgungszentren der Krankenhäuser einer Nachhaltigkeitsprüfung zu unterziehen. Patienten profitieren dabei von der Verbesserung der Gesamtqualität der Versorgung.
Vernetzen: Die Rolle von Standards für das LkSG
Authors: Uhlig Peter
Published: December 2024

Das LkSG hat das Ziel, Menschenrechte und Umweltstandards in globalen Lieferketten zu gewährleisten. Trotz bürokratischer Hürden sehen einige Unternehmen im LkSG die Möglichkeit, ihre Lieferketten transparenter zu gestalten und ihre Reputation zu verbessern.
Wertemanagement: Ethik und Compliance in Einkauf und Logistik im Krankenhaus
Authors: Kriegel Johannes
Published: December 2024

Das Krankenhaus ist ein komprimierter sozialer Raum, in dem ethisch-kulturelle Prinzipien, wie Gesundheit, Selbstbestimmung, Gerechtigkeit, Gemeinwohl und Nachhaltigkeit im Vordergrund stehen. Gleichzeitig ergeben sich vielfältige Interessenkonflikte und Entscheidungsdilemma, die es auch im Einkauf und der Logistik im Krankenhaus zu beachten gilt.
Hohe Wirksamkeit bei kutanen T-Zell-Lymphomen
Authors: Arnheim Katharina
Published: December 2024

Seit 4 Jahren steht der monoklonale Antikörper Mogamulizumab für die Behandlung von Mycosis fungoides
(MF) und Sézary-Syndrom (SS) in Deutschland zur Verfügung. Mittlerweile wurden umfangreiche Erfahrungen
mit dem Wirkstoff im klinischen Alltag gesammelt.
Immunbedingte Nebenwirkungen: Wie erkennen – wie behandeln?
Authors: Arnheim Katharina
Published: December 2024

Immunbedingte Nebenwirkungen unter einer Therapie mit Checkpoint-Inhibitoren (CPI) sind nicht selten.
Während des 34. Deutschen Hautkrebskongresses in Würzburg wurden weniger bekannte dieser Nebenwirkungen
und der Umgang damit vorgestellt.
Angeborener Porto-phrenico-pulmonaler Shunt bei einer
Katze
Authors: Redlich Carl-Christian
Published: December 2024

Eine 8 Monate alte männlich-unkastrierte Heilige Birma mit rezidivierender
Strangurie, Haematurie und intermittierendem Kopftremor wurde in unserer Klinik
mit Verdacht eines Hepatoenzephalen Syndroms zur weiteren Diagnostik
vorgestellt. Eine Computertomografie zeigte ein aus der Vena gastrica sinistra
entspringendes Shuntgefäß, das sich sowohl mit der Vena phrenica sinistra als
auch mit einem in das linke Atrium mündenden Lungengefäß verband. Dies ist der
erste Fallbericht, der das radiologische Erscheinungsbild, den operativen
Verschluss und den postoperativen Verlauf einer solchen Shuntform bei einer
Katze beschreibt.
Intraosseous Transcutaneous Amputation Prosthesis (ITAP) compared to
Exoprosthesis in veterinary medicine – a literature review
Authors: Kneringer Clara , Schnabl-Feichter Eva
Published: December 2024

Objective This literature review aims to provide an overview of the
existing literature on intraosseous transcutaneous amputation prosthesis (ITAP)
and stump socket prosthesis in amputated animals. The goal is to compare the
advantages and disadvantages of ITAP with exoprosthesis use, given the
importance of limb-sparing procedures in contemporary veterinary medicine.

Materials and methods A systematic research adhering to the PRISMA
protocol was conducted using a time span from 2000 to 2023, focusing on papers
detailing the clinical application of ITAP or exoprosthesis in small
animals.

Results This review encompasses 8 studies, 5 of them offering insights
into the use of exoprosthesis in dogs and cats and 3 into ITAPs. Among the
patients receiving an ITAP, 2 out of 6 experienced complications such as implant
loosening and breakage. Studies on stump socket prostheses identified 10
different complications, occurring 93 times in 96 canine patients, with some
patients showing more than one complication. However, in the studies assessing
the quality of life, 31 out of 48 owners reported that their dogs had a good or
excellent quality of life post-surgery.

Conclusion Both approaches have their pros and cons. Stump socket
prostheses may offer better adaptability and simpler application, but owners
must be vigilant about daily maintenance to prevent pressure sores or
infections, often necessitating adaptations due to stump changes. In contrast,
ITAP avoids these complications but requires assurance of proper skin and bone
integration. The positive aspect of both prosthesis types lies in restoring
quadrupedal gait, alleviating strain on other limbs and maintaining
physiological posture, particularly crucial for animals with preexisting
conditions. It is crucial to carefully evaluate the outcomes and potential
complications of each prosthesis type, prioritizing the patient’s
well-being.

Clinical relevance Limb amputation is an important decision in veterinary
medicine, where alternative options beyond total limb amputation should be
thoroughly discussed. Partial limb amputation, along with prosthetic devices,
can greatly benefit patients, provided careful consideration and planning are
undertaken.
Integration: Aschaffenburg-Alzenau setzt auf digitale Prozesse
Authors: Rau Angelina
Published: December 2024

Das Klinikum Aschaffenburg-Alzenau hat Ende 2024 die Integration mit Prospitalia erfolgreich abgeschlossen und berichtet über seine bisherigen Erfahrungen. Im Interview gibt Thomas Willms, Einkaufsleiter des Klinikums, Einblicke in den Integrationsprozess, die Vorteile des Prospitalia Cockpits und die Mehrwerte der Zusammenarbeit mit dem Einkaufsdienstleister.
Herausforderung: Sechs Euro pro Tag – so knapp ist das Verpflegungsbudget
Authors: Fiala Marieke , Hofmann Lisa-Marie
Published: December 2024

Auch die tägliche Verpflegung von Klinikpatienten ist – ähnlich zu anderen Medizinbereichen – einem hohen Kostendruck ausgesetzt. Als Krankenhaus dabei noch nachhaltig zu agieren und gesunde Speisen auf den Tisch zu bringen, ist eine Herausforderung.
Highlights von der DGHO-Jahrestagung 2024
Authors: Schöllmann Claudia
Published: December 2024

Mitte Oktober 2024 fand die Jahrestagung 2024 der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie (DGHO, OeGHO, SGMO und SGH) in Basel/Schweiz statt. Im Fokus der 5500 Teilnehmenden standen der persönliche Erfahrungsaustausch, die Einordnung relevanter Studiendaten in die Versorgungsroutine, aber auch aktuelle Ergebnisse aus Klinik und Praxis. Wir stellen ausgewählte Kongress-Highlights aus der Hämatoonkologie vor.
Gastrointestinale Tumoren: Effekte von Ernährung und Genetik untersucht
Authors: Lichert Frank
Published: December 2024

Die Ernährung gilt als wichtiger Einflussfaktor im Rahmen der Krebsentstehung. Gesunde Ernährungsmuster können möglicherweise dazu beitragen, das Risiko für bestimmte Krebserkrankungen des Gastrointestinaltraktes (GIC) wie Magenkrebs oder das kolorektale Karzinom zu reduzieren. Y. Cai et al. haben in einer Studie untersucht, wie unterschiedliche Ernährungsansätze und die genetische Veranlagung das GIC-Risiko beeinflussen.
Stadium-II-Endometriumkarzinom: präoperative Beurteilung der Zervixstromainvasion
Authors: Lorenz Judith
Published: December 2024

Beim Endometriumkarzinom hängt die Radikalität des operativen Eingriffs unter anderem vom Ausmaß des Zervix- und des Parametrienbefalls ab. Ein Forscherteam aus Italien ging nun der Frage nach, wie gut sich die Tumorausdehnung präoperativ mittels hysteroskopischer Exzisionsbiopsie allein oder in Kombination mit einer Magnetresonanztomografie (MRT) vorhersagen lässt.
Brustwarzenerhaltende Mastektomie: Ist die MRT-Nachsorge sinnvoll?
Authors: Lorenz Judith
Published: December 2024

Viele Mammakarzinompatientinnen entscheiden sich für eine brustwarzenerhaltende Mastektomie (NSM: Nipple-sparing Mastectomy). Die optimale postoperative Nachsorgestrategie ist allerdings unklar. Ein US-Forscherteam sieht hier einen Standardisierungsbedarf und ging daher der Frage nach, inwiefern sich die Überwachung mittels klinischer Brustuntersuchung bzw. Magnetresonanztomografie (MRT) bezüglich der onkologischen Prognose unterscheidet.
Sekundärmalignome nach CAR-T-Zelltherapie
Authors: Lorenz Judith
Published: December 2024

CAR-T-Zellen (chimäre Antigenrezeptor-T-Zellen) sind wirksame immunologische Onkotherapeutika. Allerdings bergen sie potenziell die Gefahr von Sekundärmalignomen, insbesondere T-Zell-Neoplasien, die als Folge einer Integration des viralen Vektors mit maligner Lymphozyten-Transformation auftreten. Eine Arbeitsgruppe von der Stanford Universität in Kalifornien wertete nun Behandlungsergebnisse von Patientinnen und Patienten unter diesem Aspekt aus.
Perioperatives Nivolumab beim nicht kleinzelligen Lungenkarzinom
Authors: Lorenz Judith
Published: December 2024

Menschen mit einem operablen, nicht kleinzelligen Lungenkarzinom (NSCLC) profitieren hinsichtlich des Tumoransprechens und der Überlebensprognose von einer neoadjuvanten Vorbehandlung mit platinbasierter Chemotherapie in Kombination mit Nivolumab, einem gegen den PD1-Rezeptor gerichteten Antikörper. Die Studie CheckMate 77 T untersuchte nun den Nutzen einer zusätzlichen adjuvanten Behandlung mit dem Checkpoint-Inhibitor nach der Operation.
Temporary Nasal Morbidity after Expanded Endoscopic Endonasal Surgery for Skull Base Tumors
Authors: Chiramal Lidia Dennis , Sundarasan Rajan , Chacko Ari G. , Thomas Regi
Published: December 2024

Objectives To assess olfactory dysfunction and quality of life (QOL) in patients undergoing expanded endoscopic endonasal approach for skull base tumors.

Design Prospective observational study of patients undergoing expanded endoscopic endonasal approach for anterior skull base and pituitary lesions from 2018 to 2019.

Setting Christian Medical College and Hospital, Vellore, Tamil Nadu, India.

Participants A total of 29 consecutive patients who underwent expanded endoscopic endonasal approach.

Main Outcome Measures Olfactory function and QOL were assessed using Connecticut Chemosensory Clinical Research Centre olfaction test and Sino Nasal Outcome Test 22 questionnaire, respectively, preoperatively and at the 2nd week and 3rd month postoperative follow-up.

Results Olfaction scores significantly worsened in the 2 weeks postoperative period compared with the preoperative scores. By 3rd postoperative month 48% of the patients returned to baseline, 48% had only mild hyposmia, and only 1 patient had persistent moderate hyposmia. QOL scores significantly worsened in the immediate postoperative period and although they improved over 3 months, they did not reach baseline.

Conclusion Expanded endoscopic endonasal approaches to the anterior skull base cause transient olfactory dysfunction and nasal morbidity in the immediate postoperative period. Although olfactory function and QOL scores improved in the majority of patients, at least 50% had mild residual dysfunction at 3 months postoperatively. Olfactory epithelium-preserving surgical techniques, adequate endoscopic nasal cleaning postoperatively, and good nasal douching are factors that help improve olfactory function postoperatively.
Tötung im Saufang
Authors: Westhoff Katharina M. , Fetzer André , Lang Johannes , Lierz Michael
Published: December 2024

Gegenstand und Ziel Der Saufang als Methode der Tierseuchenbekämpfung ist
mit der Ausbreitung der Afrikanischen Schweinepest in Deutschland wieder neu in
den Fokus gerückt. Daten zum Kugelschuss bei Haussäugetieren sind vorhanden,
allerdings fehlen Daten zur Tötung und Kaliberwahl für die Anwendung bei
Wildschweinen im Saufang weitestgehend.

Material und Methoden Die Köpfe von 138 in Saufängen gefangenen und mit
Kopfschuss (Kaliber .22 lfB) getöteten Wildschweinen wurden auf die Anzahl an
Einschüssen, Einschusslokalisation und Gewebeschäden am Gehirn anhand von
Gefrierschnitten analysiert.

Ergebnisse Bis auf ein Tier konnten alle Wildschweine mit dem Kaliber per
Kopfschuss sicher getötet werden. Bei 76% (105/138) der Wildschweine wurde ein
einzelner Einschuss am Kopf festgestellt und bei 96% (126/131) der Tiere wurde
eine Schädigung im Endhirn in unterschiedlichen Schweregraden nachgewiesen. Bei
den Tieren mit einem frontalen Einschuss, bei denen eine Schädigung im Großhirn
und im Stammhirn in den Gefrierschnitten festgestellt wurde (n=77) lag dieser im
Mittel 2,2 cm oberhalb der Augenlinie und 0,35 cm rechts der Medianen.

Schlussfolgerung Das Kaliber .22 lfB erscheint nach den vorliegenden
Untersuchungen für den Einsatz bei mittelgroßen Saufängen zur Tötung von
Wildschweinen mit dem frontalen Kopfschuss ausreichend. Die Wahl des
kleinstmöglichen Kalibers ist aus Gründen des Tierschutzes (Verletzung anderer
Tiere durch Ausschüsse) und der Sicherheit für das ausführende Personal im
Saufang von großer Bedeutung.
Augmented Reality unterstützt roboterassistierte Nierenchirurgie
Authors: Lorenz Judith
Published: December 2024

Die Augmented Reality (AR)-Technologie („erweiterte Realität“) eröffnet neue Perspektiven für die roboterassistierte Nierenchirurgie. Die Erweiterung der Wahrnehmung während der Live-Operation um präoperativ mittels Bildgebung gewonnene, patientenspezifische, dreidimensionale Modelle funktioniert gegenwärtig allerdings noch nicht reibungslos. Ein Forscherteam aus Belgien löste nun eines der bei der Modellintegration auftretenden Probleme.
Organisiertes Prostatakarzinomscreening: Erste Erfahrungen aus Schweden
Authors: Lorenz Judith
Published: December 2024

Im Jahr 2020 startete in Schweden erstmals ein regional organisiertes bevölkerungsbasiertes Prostatakarzinomscreening, das alle Schritte von der Einladung bis zur Besprechung von Biopsiebefunden umfasst. Im September 2023 hatten bereits 8 von 21 Regionen entsprechende Programme initiiert. Forschende analysierten nun erste Daten zur Machbarkeit und Effektivität des Tumorscreenings inklusive der Teilnahmeraten und der diagnostischen Ergebnisse.
Severe Disease Activation after Fingolimod Discontinuation in a Pediatric Multiple Sclerosis Patient: A Case Report and Literature Review
Authors: Huppke Brenda , Vries Heike de , Blaschek Astrid , Huppke Peter
Published: December 2024

Adult reports of unexpected severe disease worsening, often termed “rebound,” shortly after discontinuing fingolimod in a subset of patients with multiple sclerosis (MS), have grown over the last decade. This phenomenon, however, remains poorly described in pediatric MS patients. We present findings of a 15-year-old who experienced a debilitating relapse 4 weeks after stopping fingolimod to switch to ocrelizumab. Imaging revealed multiple large new lesions far exceeding any previously observed activity level in the patient. Despite prompt high-dose corticosteroids, plasma exchange, and prolonged rehabilitation therapy, significant residual deficits involving cognition, balance, and vision remain from the attack. This case underscores that pediatric MS patients are also at risk of severe disease deterioration after fingolimod withdrawal and require close monitoring when switching therapies.
Three-Component Synthesis of Cyanopyrazoles Employing Diazo­acetonitrile
Authors: Mohanan Kishor , Singroha Rekha , Onen Patrick , Yadav Usha , Kant Ruchir
Published: December 2024

An efficient three-component reaction involving aldehydes, β-ketophosphonates, and diazoacetonitrile has been developed for the construction of highly substituted cyanopyrazoles. The reaction proceeds by a three-step, domino process comprised of a base-mediated Horner–Wadsworth–Emmons reaction/(3+2) cycloaddition and subsequent oxidation to form pyrazole derivatives. A wide range of readily available aldehydes and ketophosphonates were used to access these exciting scaffolds under mild conditions.
Kinetic theory of stellar systems: A tutorial
Authors: Hamilton Chris , Fouvry Jean-Baptiste
Published: December 2024

Stellar systems—globular and nuclear star clusters, elliptical and spiral galaxies and their surrounding dark matter haloes, and so on—are ubiquitous characters in the evolutionary tale of our Universe. This tutorial article is an introduction to the collective dynamical evolution of the very large numbers of stars and/or other self-gravitating objects that comprise such systems, i.e., their kinetic theory. We begin by introducing the basic phenomenology of stellar systems, and explaining why and when we must develop a kinetic theory that transcends the traditional two-body relaxation picture of Chandrasekhar. We then study the individual orbits that comprise stellar systems, how those orbits are modified by linear and nonlinear perturbations, how a system responds self-consistently to fluctuations in its own gravitational potential, and how one can predict the long-term evolutionary fate of a stellar system in both quasilinear and nonlinear regimes. Though our treatment is necessarily mathematical, we develop the formalism only to the extent that it facilitates real calculations. Each section is bolstered with intuitive illustrations, and we give many examples throughout the text of the equations being applied to topics of major astrophysical importance, such as radial migration, spiral instabilities, and dynamical friction on galactic bars. Furthermore, in the 1960s and 1970s, the kinetic theory of stellar systems was a fledgling subject which developed in tandem with the kinetic theory of plasmas. However, the two fields have long since diverged as their practitioners have focused on ever more specialized and technical issues. This tendency, coupled with the famous obscurity of astronomical jargon, means that today relatively few plasma physicists are aware that their knowledge is directly applicable in the beautiful arena of galaxy evolution, and relatively few galactic astronomers know of the plasma-theoretic foundations upon which a portion of their subject is built. Yet, once one has become fluent in both Plasmaish and Galacticese, and has a dictionary relating the two, one can pull ideas directly from one field to solve a problem in the other. Therefore, another aim of this tutorial article is to provide our plasma colleagues with a jargon-light understanding of the key properties of stellar systems, to offer them the theoretical minimum necessary to engage with the modern stellar dynamics literature, to point out the many direct analogies between stellar- and plasma-kinetic calculations, and ultimately to convince them that stellar dynamics and plasma kinetics are, in a deep, beautiful and useful sense, the same thing.
Chaotification and chaos control of q-homographic map
Authors: Aishwaraya  , Chandramouli V. V. M. S.
Published: December 2024

This paper concerns the dynamical study of the q-deformed homographic map, namely, the q-homographic map, where q-deformation is introduced by Jagannathan and Sinha with the inspiration from Tsalli’s q-exponential function. We analyze the q-homographic map by computing its basic nonlinear dynamics, bifurcation analysis, and topological entropy. We use the notion of a false derivative and the generalized Lambert W function of the rational type to estimate the upper bound on the number of fixed points of the q-homographic map. Furthermore, we discuss chaotification of the q-deformed map to enhance its complexity, which consists of adding the remainder of multiple scaling of the map’s value for the next generation using the multiple remainder operator. The chaotified q-homographic map shows high complexity and the presence of robust chaos, which have been theoretically and graphically analyzed using various dynamical techniques. Moreover, to control the period-doubling bifurcations and chaos in the q-homographic map, we use the feedback control technique. The theoretical discussion of chaos control is illustrated by numerical simulations.
Nonlinear optical response and bistability of intersubband polariton in a planar microcavity: Role of dynamic Coulomb coupling
Authors: Bondarenko Victor
Published: December 2024

We theoretically investigate the steady-state bistable intersubband polariton response of quantum-well (QW) structures embedded into planar semiconductor microcavity to intense plane wave incident radiation. A rigorous semiclassical approach employs the transfer matrix formalism and the sheet model, which includes the dynamic depolarization effect. Results of comprehensive numerical simulations on reflectance characteristics of the structures with strong coupling between the ground cavity mode of the electromagnetic field and intersubband excitations in QWs are presented. The mechanism of the polariton-based optical bistability (OB) is revealed. Both the mirror-based optical bistability (MOB) and the intrinsic optical bistability (IOB) are investigated, with the focus on the MOB. Polariton-based bistabilities driven by cyclically changing intensity of the incident radiation, frequency of the incident radiation, and the angle of incidence are considered. It is found that the presence of the dynamic depolarization effect brings novel features to the OB reflectance characteristics of the structures. Effect of accumulation of the MOB cooperativity parameter is revealed. The concept of effective QW is proposed to describe a tremendously enhanced MOB response of multiple identical QWs particularly located in the cavity. A remarkable possibility of MOB in systems of multiple particularly located QWs with big values of dephasing rate is demonstrated. It is shown that the transition from bistability to multiple bistability and to multistability for two QWs can be controlled by slight manipulation of the angle of incidence. A possibility is found for an outstanding width of the hysteresis of the angular-domain OB, being about one degree.
Open-jet testing: Investigating turbulence and geometric scale effects on surface pressures in the atmospheric boundary layer
Authors: Aly Aly Mousaad , Khaled Md. Faiaz
Published: December 2024

Bluff body aerodynamics is essential for the design and safety of structures exposed to wind forces. Traditional atmospheric boundary layer wind testing often fails to replicate the complex turbulence characteristics of real-world flows, necessitating innovative testing methodologies. We developed an open-jet testing approach and conducted experiments on scaled models (1:7.6 and 1:10) at Reynolds numbers ranging from 0.5 × 106 to 1 × 106, significantly higher than those typically achieved in conventional testing. This methodology produced integral length scales approximately ten times larger than those observed in traditional methods, resulting in 25%–300% higher peak pressures than those from small-scale tests, closely aligning with full-scale field data. Our findings emphasize the necessity of testing under complete atmospheric boundary layer turbulence to ensure accurate wind pressure predictions. Insights into the effects of advanced flow on separation, reattachment, and pressure distribution inform new experimental protocols and have significant implications for the design and safety of structures in wind-prone regions. By establishing a robust benchmark for future experimental and computational simulations in wind engineering, this approach promotes the development of safer, more resilient, and economically viable building designs capable of withstanding extreme wind events exacerbated by climate change, contributing to sustainable infrastructure advancement.
Critical Casimir levitation of colloids above a bull’s-eye pattern
Authors: Nowakowski Piotr , Farahmad Bafi Nima , Volpe Giovanni , Kondrat Svyatoslav , Dietrich S.
Published: December 2024

Critical Casimir forces emerge among particles or surfaces immersed in a near-critical fluid, with the sign of the force determined by surface properties and with its strength tunable by minute temperature changes. Here, we show how such forces can be used to trap a colloidal particle and levitate it above a substrate with a bull’s-eye pattern consisting of a ring with surface properties opposite to the rest of the substrate. Using the Derjaguin approximation and mean-field calculations, we find a rich behavior of spherical colloids at such a patterned surface, including sedimentation toward the ring and levitation above the ring (ring levitation) or above the bull’s-eye’s center (point levitation). Within the Derjaguin approximation, we calculate a levitation diagram for point levitation showing the depth of the trapping potential and the height at which the colloid levitates, both depending on the pattern properties, the colloid size, and the solution temperature. Our calculations reveal that the parameter space associated with point levitation shrinks if the system is driven away from a critical point, while, surprisingly, the trapping force becomes stronger. We discuss the application of critical Casimir levitation for sorting colloids by size and for determining the thermodynamic distance to criticality. Our results show that critical Casimir forces provide rich opportunities for controlling the behavior of colloidal particles at patterned surfaces.