bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluación de tres técnicas de licuefacción del semen de alpaca y su efecto sobre la viscosidad seminal, motilidad y viabilidad espermática
Authors:   , Vilca Sulca Melissa Margaret
Published: February 2024

La viscosidad del plasma seminal limita el manejo del semen de alpaca en el laboratorio. Para solucionar este inconveniente, se han investigado diferentes técnicas de licuefacción del plasma seminal, como el pipeteo, centrifugación y métodos enzimáticos; sin embargo, la calidad del esperma puede verse afectada. El objetivo de este estudio fue evaluar tres técnicas de licuefacción de semen de alpaca (T1: actividad mecánica, T2: vibración y T3: papaína + E-64) y su efecto sobre la viscosidad seminal, motilidad y viabilidad espermática. Se colectaron 15 muestras seminales de machos reproductores en la Universidad Científica del Sur. Luego, cada eyaculado se dividió en tres alícuotas, una para cada tratamiento. Se evaluó los parámetros de viscosidad, motilidad y viabilidad de la muestra inicial y posterior a cada tratamiento. Todos los tratamientos eliminaron la viscosidad con respecto al valor inicial (p<0.05). Los porcentajes promedios de motilidad y viabilidad en el tratamiento papaína más E-64 fueron superiores a los demás tratamientos, además que estos valores se acercaron más a la media inicial. Se concluyó que el tratamiento más eficaz para eliminar la viscosidad seminal, sin generar efectos negativos sobre los parámetros de motilidad y viabilidad espermática, fue la papaína más su inhibidor (E-64).
Nivel de conocimiento en nutrición y satisfacción de imagen corporal de los estudiantes de Medicina de Universidades del Perú
Authors:   , Cavides Gutierrez Maried , Jevtic Santander Jovan
Published: February 2024

Objetivo: El objetivo del estudio es determinar la asociación entre el nivel de conocimiento en Nutrición y la satisfacción de imagen corporal en estudiantes de Medicina de universidades del Perú. Material y métodos: Se llevó a cabo un estudio transversal, observacional, analítico en un total de 183 estudiantes. Estudio realizado en universidades una de la capital y otra de la región andina del Perú durante el periodo de Junio-Julio 2023 mediante encuestas virtuales. El muestreo fue no probabilístico. Se midió la variable nivel de conocimiento en nutrición con la escala ‘’Nutrition knowledge questionaire’’ y satisfacción de imagen corporal con la escala ‘’The body image questionaire’’. Resultados: Los resultados mostraron que, a mayor nivel de conocimiento en Nutrición, es mayor la satisfacción de imagen corporal. El promedio de nivel de conocimiento en Nutrición fue de 9.96 con una desviación estándar de 2.66 y la mediana de satisfacción de imagen corporal fue de 16.0 con un rango intercuartílico de 4.6. El coeficiente de correlación Spearman entre ambas variables fue de 0.40 y se calculó un coeficiente ß de 0.52 con error estándar de 0.11 e intervalo de confianza de 95% cuando se analizó las variables principales en un modelo crudo. Conclusiones: El mayor nivel de conocimiento en Nutrición se asocia a mayor satisfacción de imagen corporal.
Calidad de vida en mujeres con desordenes tiroideos controlados: revisión sistemática
Authors:   , Ortega Guerreros Priscila Lucero , Quispe Ronceros Amhed Takeshi
Published: February 2024

Objetivo: El objetivo principal es describir, evaluar y determinar el nivel de calidad de vida en mujeres adultas premenopáusicas con desórdenes tiroideos funcionales controlados. Metodología: Se realizó una búsqueda bibliográfica sistemática en las bases de datos de PubMed / Medline, Scopus, Ovid, SciELO, Web of Science y Google Scholar, se procedió a extraer los artículos seleccionados al software EndNote X9 y se realizó una primera lectura a través de título y abstracts de los cuales se eliminaron aquellos que no guardaban relación. Se procedió a una segunda lectura de los artículos restantes a texto completo y se eliminó aquellos que no tenían relación con nuestro estudio. Resultados: Cinco estudios fueron los que quedaron seleccionados. Uno describe la calidad de vida en los pacientes con oftalmopatía de Graves a través del cuestionario GO-QOL en Taiwán, El segundo estudió pacientes con hipotiroidismo a través de los cuestionarios ThyPRO en su versión corta, ThyPRO-39, en Pakistán. El tercero estudió pacientes con enfermedad de Graves en Suecia. El cuarto estudió diversas patologías tiroideas a través de los cuestionarios SF-36 y ThyPRO en Egipto, y el último, en Países Bajos, incluyó pacientes con hipertiroidismo usando como cuestionario el HCQ. Conclusiones: La calidad de vida en pacientes con desórdenes tiroideos controlados es influenciada por la patología subyacente, el hipertiroidismo y la Orbitopatía de Graves obtuvieron una adecuada calidad de vida, caso contrario al Hipotiroidismo en el que la calidad de vida resultó inadecuada. Los síntomas residuales como el cansancio, depresión y ansiedad fueron los más predominantes.
Educación financiera y capacidad de ahorro en estudiantes universitarios Lima Sur Perú 2022
Authors:   , Vicente Sanchez Karen Celeste , Venegas Arevalo Rocio Elizabeth
Published: February 2024

La educación financiera y el ahorro son dos factores importantes en el comportamiento económico del estudiante universitario, porque permite alcanzar la autonomía económica y aumentar el bienestar personal o familiar. El objetivo de la presente investigación es determinar como la educación financiera se relaciona con la capacidad de ahorro en estudiantes universitarios Lima Sur Perú 2022. Se empleó el método de enfoque cuantitativo y correlacional con diseño no experimental de corte transversal, seguida de la selección de datos recogida mediante la colocación de una encuesta a una muestra de 380 estudiantes, utilizando como instrumento el cuestionario bajo el formato de escala de Likert, cuyos datos fueron sometidos al análisis psicométrico, dando resultados positivos en la validez y confiablidad. Luego del procesamiento de datos, en la contrastación de hipótesis se concluyó que, existe una relación directa y significativa con un coeficiente de correlación (r= 0.779) positiva considerable entre educación financiera y capacidad de ahorro en estudiantes universitarios Lima Sur Perú 2022.
A new equation of four infinite series and sums by using a generalized recurrence relation
Authors: Louiz Akram
Published: February 2024

Motivated by the fundamental presence of mathematics in all engineering and scientific fields, I made this mathematical article in order to answer many of my personal questions which are also not answered questions in mathematics. This is a mathematical article that proves a useful recurrence relation that is very useful for mathematics demonstrations. The article proves also that four infinite series are equivalent. Hence, this article opens new opportunities to demonstrate and develop new mathematical findings and observations. The demonstrated formulas of this article can also be very useful for all the fields that apply mathematics and especially infinite series and sums.
Investigation of geomagnetic field variations in search of seismo-electromagnetic emissions associated with earthquakes in subduction zone of Andaman-Nicobar, India
Authors: Prajapati Rahul , Arora Kusumita
Published: February 2024

The study of seismo-electromagnetic (EM) emissions has the potential to provide new insights into the physics of seismic activity and improve our ability to monitor and predict earthquakes and other geophysical events. Continuous recording and monitoring of EM fields in seismically active areas are very complex, but it can open a new regime in the field of earthquake prediction. In this study, one year of ground based geomagnetic data during March 2019 to April 2020 in seismic active subduction zone of Andaman-Nicobar region in search of EM signatures related to lithospheric processes. An anomalous signature in the vertical component of geomagnetic field is preferred to study after removing the global and seasonal effect from the data. Apart from vertical component of geomagnetic field, polarization ratios which also include horizontal component, also studied from spectral density with the same purpose in ULF range. Over the duration of one year, we noted an 80% enhancement in polarisation ratios and 67% deviations in diurnal ratios average 18 days before of earthquake events. Apart from that, the significant enhancements in diurnal and polarization ratio were shown to be successfully correlated with 11 out of 14 earthquakes which is equivalent to approximately 78% success ratio.
Green synthesis of iron oxide nanoparticles using plant extracts and evaluation of their antibacterial activity
Authors: elkhateeb Omima , Atta Mohamed B. , mahmoud esawy
Published: February 2024

Green synthesis of iron oxide nanoparticles has received increasing attention in the field of food nanotechnology because of its non-toxic, high efficiency, high antibacterial power, and decontamination features. Therefore, nanoparticles of green iron oxide (nFe) were prepared from the leaves of some vegetables, such as cabbage (C) and turnip (T), as well as moringa leaves (M). The alcoholic extracts of these nanoparticles were also tested as the anti-growth of some pathogenic microbes, namely. The results revealed that the particle sizes of the green nanomaterials studied ranged from 12.99 to 22.72 nm, and the particles were spherical, irregular, and surrounded by black. It also contains many functional groups and minerals. Iron nanoparticles modified with Moringa oleifera extract at a concentration of 200 ppm had the highest phenols content compared to other green nanoparticles studied. TnFe and MnFe at 200 ppm had a maximum zone of inhibition of 25 mm and 24 mm against Staphylococcus aureus and Escherichia coli, respectively. While the minimum inhibition zone of 8.0 mm was observed at 25 ppm for nFe against Escherichia coli. Therefore, it is recommended to use these extracts of green iron oxide nanoparticles as antibacterial agent for stored foods.
Potential alternative land covers on Earth
Authors: Bastin Jean-Francois , Latte Nicolas , Garcia Claude , Berzaghi Fabio , Maestre Fernando , Svenning Jens-Christian , Bogaert Jan , Assede Emeline , Barima Sabas , Besisa Timothée , Bouchoms Samuel , de Haulleville Thalès , de Lame Hugo , Depoortere Pauline , Dufrêne Marc , Dijke Anne Hoek van , Lejeune Philippe , Lhoest Simon , Mahy Gregory , Messier Christian , Mollicone Danilo , Peaucelle Marc , Plumacker Antoine , Quétier Fabien , Rakotondrasoa Olivia , Ramalason Felana , Sambieni Raoul , Sparrow Ben , Strammer Harold , Tarelkin Yegor , Sikuzani Yannick Useni , Linden Arthur Vander
Published: February 2024

Preserving and restoring terrestrial ecosystems is crucial to halting the collapse of life on Earth. To guide global conservation and restoration efforts, we present a comprehensive map, encompassing all ecosystems, revealing the Earth's potential tree, short vegetation, and bareground cover accounting for various land management scenarios such as prescribed fire frequency and trophic rewilding. Our analysis indicates that 43% (5678 Mha) of lands could be covered by trees, 39% (5179 Mha) by shrubs and grasses, and 18% (2347 Mha) by bareground. Approximately 1070 Mha can support alternative land covers, emphasizing the need to consider diverse outcomes in landscape restoration. Our findings also suggest that management scenarios may significantly outweigh the average impact of climate change on resulting land covers, underscoring decision-makers' responsibility for nature’s recovery and a sustainable future.
Demographic changes in COVID-19 mortality during the pandemic: Analysis of trends in disparities among workers using California’s Mortality Surveillance System
Authors: Gebreegziabher Elisabeth , Bui David , Cummings Kristin J. , Frederick Matthew , Nguyen Alyssa , Collins Caroline , Melton David , Yang Alice , Jain Seema , Vergara Ximena
Published: February 2024

Background
There is limited information on the extent and patterns of disparities in COVID-19 mortality throughout the pandemic. We aimed to examine trends in disparities by demographics over variants among Californian workers using a social determinants of health lens.
Methods
Using death certificates, we identified all COVID-19 deaths that occurred between January 2020 and May 2022 among workers aged 18–64 years in California. We derived estimates for at-risk worker populations using the Current Population Survey. The waves of COVID-19 mortality were March 2020-June 2020 (wave 1), July 2020-November 2020 (wave 2), December 2020-May 2021 (wave 3), June 2021-January 2022 (wave 4), and February 2022-May 2022 (wave 5). Poisson regression models with robust standard errors were used to determine wave-specific mortality rate ratios (MRRs). We examined the change in MRR across waves by including an interaction term between each demographic characteristic and wave period in different models.
Results
Among the 24.1 million working age CA population included in the study, there were 26,068 COVID-19 deaths in the period between January 2020 and May 2022. Compared with their respective reference groups, workers who were 50–64 years old, male, Native Hawaiian, Latino, or African American, foreign-born; individuals who had lower education; and unmarried were disproportionately affected by COVID-19 mortality. While disparities by sex, race and foreign-born status narrowed in later waves, disparities by age, education level and marital status did not change substantially across waves.
Conclusion
The existence of disparities across all waves of the pandemic, even in an era of widespread vaccine coverage, could indicate remaining gaps in prevention and differential vulnerability. Addressing the underlying social, structural, and occupational factors that contribute to these disparities is critical for achieving health equity.
A predictive model of pediatric postoperative pulmonary complications following one-lung ventilation
Authors: Wang Lei , Xiao Ting , Du Zhen , Chen Tiange , Pei Dongjie , Qu Shuangquan
Published: January 2024

Since the disparities in respiratory anatomy and physiology between children and adults, children are more susceptible to postoperative pulmonary complications (PPCs) after one-lung ventilation (OLV). Hypothesizing that the incidence of PPCs could be predicted using easily accessible perioperative variables, we aimed to develop a nomogram specifically for children receiving thoracic surgery with OLV. The outcome of this study was the incidence of PPCs. Univariate analysis and the least absolute shrinkage and selection operator regression model were applied to select the most relevant prognostic predictors. Multivariable logistic regression was used to develop a nomogram based on the selected prediction factors. Internal validation was conducted to evaluate its performance. Following screening, a total of 249 children were ultimately included in the study. Among them, 89 (35.7%) presented PPCs. Four predictive factors were ultimately chosen for nomogram development: preoperative neutrophil-to-lymphocyte ratio, intraoperative ventilation mode, maximum peak airway pressure, and minimum oxygenation index during OLV. By incorporating of these four factors, the nomogram achieved an area under the curve of 0.846 [95% confidence interval, 0.797-0.894) with well-fitted calibration curves. In conclusion, this nomogram, based on four factors, predicts pediatric PPCs after OLV, enabling early risk assessment and interventions for better outcomes.
This study is registered at the Chinese Clinical Trial Registry (Registration number: ChiCTR2300072042, Date of Registration: 1/6/2023)
Adaptations of an Online Cognitive-Behavioral Therapy Intervention for Binge-Purge Type Eating Disorders in Publicly-Insured and Uninsured Adults: A Pilot Study
Authors: Vendlinski Siena S. , Laboe Agatha A. , Crest Peyton , McGinnis Claire G. , Fennig Molly , Wilfley Denise E. , Taylor C. Barr , Fitzsimmons-Craft Ellen E. , Accurso Erin C.
Published: February 2024

Background
Publicly-insured and uninsured individuals—many of whom are marginalized because of race/ethnicity, disability and/or sexual preferences—experience barriers to accessing evidence-based interventions for eating disorders (EDs). Additionally, EBIs have not been developed with or for diverse populations, exacerbating poor treatment uptake. Mobile technology is perfectly positioned to bridge this gap and increase access to low-cost, culturally-sensitive EBIs.
Methods
This study leverages a user-centered design approach to adapt an existing coached cognitive-behavioral therapy-based digital program and evaluate its usability in a sample of 11 participants with (sub)clinical binge-purge type EDs who are publicly-insured (n = 10) or uninsured (n = 1). Participants were primarily Non-Hispanic White (n = 8) women (n = 8). Two semi-structured interviews occurred with participants: one to assess treatment needs and the other to obtain app-specific feedback. Interviews were coded using inductive thematic analysis.
Results
Interview 1 feedback converged on three themes: Recovery Journey, Treatment Experiences, and Engagement with and Expectations for Online Programs. Participants endorsed facing barriers to healthcare, such as poor insurance coverage and a lack of trained providers, and interest in a coach to increase treatment accountability. Interview 2 feedback converged on three themes: Content Development, Participant Experiences with Mental Health, and Real-World Use. Participants liked the content but emphasized the need to improve diverse representation (e.g., gender, body size).
Conclusions
Overall, user feedback is critical to informing adaptations to the original EBI so that the intervention can be appropriately tailored to the needs of this underserved population, which ultimately has high potential to address critical barriers to ED treatment.
Trial Registration
This study was reviewed and approved by the Institutional Review Board (IRB) at the University California, San Francisco (IRB #22-35936) and the IRB at Washington University in St. Louis (IRB ID 202304167).
Associations of Air Pollution with Acute Coronary Syndromes Based on A/B/AB vs. O Blood Types – Case-crossover Study
Authors: Bochenek Tomasz , Pytlewski Adam , Bride Daniel , Gruchlik Bartosz , Lelek Michał , Teodorska Małgorzata , Nowok Michał , Wita Krystian , Stec Katarzyna Mizia , Horne Benjamin D.
Published: January 2024

Aims:
Short-term exposure to air pollutants may contribute to an increased risk of acute coronary syndrome (ACS). This study assessed the role of short-term exposure to fine particulate matter (PM2.5) as well as fine and coarse PM (PM10) air pollution in ACS events and the effect of blood groups on this phenomenon.
Methods and Results:
A retrospectively collected database of 9102 patients was evaluated. The study design was a case-crossover using a conditional logistic regression model. The main analysis focused on PM2.5 levels with a 1 day lag until the ACS event, using threshold-modelled predictor for all patients. Secondary analyses utilized separate threshold-modelled predictors for 2 to 7-day moving averages and for patients from specific ABO blood groups. Additional analysis was performed with the non-threshold models and for PM10 levels.
Short-term exposure to increased PM2.5 and PM10 levels at a 1-day lag was associated with elevated risks of ACS (PM2.5: OR= 1.012 per +10 µg/m3, 95% CI: 1.003, 1.021; PM10: OR=1.014 per +10 µg/m3, CI: 1.002, 1.025) for all the patients. Analysis pointed out that exposure to PM2.5 was associated with increased risk of ACS at a 1-day lag for the A, B or AB group (OR=1.012 per +10 µg/m3, CI: 1.001, 1.024), but not O group (OR=1.011 per +10 µg/m3, CI: 0.994, 1.029). Additional analysis showed positive association between exposure to PM10 and risk of ACS and 7-day moving average models stratified by blood group revealed that exposure to PM2.5 and PM10 was associated with elevated risk of ACS for patients with group O.
Conclusions:
Short-term exposure to PM2.5 and PM10 was associated with elevated risk of ACS. Short-term exposure to PM2.5 was positively associated with the risk of ACS for patients with A, B, or AB blood groups for a 1-day lag, while risk in O group was delayed to 7 days.
Translational Perspective:
The study assessed association between increased levels of PM2.5 and PM10 and elevated risk of ACS. Outcomes can be useful for clinical medicine practitioners by taking into account possible risk factor of ACS which could be air quality.
An ADR pharmaceutical care for severe gastrointestinal bleeding of rivaroxaban in a patient with non-valvular atrial fibrillation based on TDM and genetic testing
Authors: Chen Min , Huang Youqi , Gao Hongjin , Chen Mingyu , Lin Yuze , Liu Huiting
Published: February 2024

Background
Due to its predictable pharmacodynamics and pharmacokinetics, stable blood concentration, and relatively short half-life, rivaroxaban is widely used in the prevention and treatment of thrombosis. It nevertheless exhibits a certain level of inter-individual variability, and its safety concerns, including bleeding, are also becoming more noteworthy.
Case presentation:
This paper describes an elderly patient with nonvalvular atrial fibrillation that was complicated with coronary heart disease, who is a homozygous mutation carrier of the ABCB1 allele (rs1045642 C > T, rs1128503 C > T, rs2032582 G > T). He was developed severe gastrointestinal bleeding during administration of oral rivaroxaban combined with aspirin. We investigated the possible causes of the bleeding, and any potential correlation with the ABCB1 gene polymorphism, combined with antiplatelet drugs and anemia.
Conclusion
In the treatment of patients with atrial fibrillation, doctors should pay close attention to drug interactions with antiplatelet agents in high-risk groups and closely monitor various examination indexes, including hemoglobin. In this case, bleeding may have been associated with homozygous mutations in ABCB1, but more clinical data are needed to clarify the association between ABCB1 polymorphism and rivaroxaban pharmacokinetics and bleeding.
Twenty-year experience following aortic valve replacement in patients younger than 60 years of age
Authors: Imamura Yuki , Kowatari Ryosuke , Koizumi Junichi , Tabayashi Azuma , Saitoh Daiki , Kin Hajime
Published: February 2024

Objective: Reports on long-term outcomes of surgical aortic valve replacement (AVR) for patients aged <60 years are scarce in Japan. Hence, we aimed to evaluate these outcomes in patients aged <60 years.
Methods: Between March 2000 and December 2020, 1477 patients underwent aortic valve replacement. In total, 170 patients aged <60 years who underwent aortic valve replacement were recruited. Patients aged <18 years were excluded. Patient data collected from the operative records and follow-up assessments were reviewed.
Results: The mean age was 49±9 years, and 64.1% of patients were male. One-hundred-and-fifty-two patients (89.4%) underwent aortic valve replacement with a mechanical valve and 18 (10.6%) with a bioprosthetic valve. The mean follow-up period was 8.1±5.5 years. No operative mortality occurred, and in-hospital mortality occurred in one patient (0.6%). Ten late deaths occurred, with seven cardiac-related deaths. The overall survival rate was 95.4±1.7%, 93.9±2.3%, 90.6±3.9%, and 73.2±11.8% at 5, 10, 15, and 20 years, respectively. Freedom from major bleeding was 96.4±1.6% at 5, 10, and 15 years, and 89.0±7.3% at 20 years. Freedom from thromboembolic events was 98.7±1.3%, 97.3±1.9%, 90.5±4.5%, and 79.0±11.3% at 5, 10, 15, and 20 years, respectively. Freedom from valve-related reoperation was 99.4±0.6% at 5 years, 97.8±1.7% at 10 and 15 years, and 63.9±14.5% at 20 years.
Conclusions: Patients aged <60 years undergoing aortic valve replacement with a high mechanical valve implantation rate had favorable long-term outcomes.
Genetic analysis on basmati rice varieties in Indian market using SSR markers
Authors: Kuncham Ramprasad , Mohanty Mausumee , Goriparthi Koteswara Rao , Thekkeetil Prasanth , Vannereddy Muniraju , Sivaprakasam Thiyagarajan
Published: February 2024

In the world of rice, among the thousands of varieties that are available, inarguably Basmati rice occupies the prime position due to its accoladed traits such as grain morphology, quality, fragrance, taste, fluffy texture, and tenderness of cooked rice. Due to these unique traits, Basmati rice that is exported from India and Pakistan earns triplex price compared to domestic non-basmati rice varieties. Among the Basmati rice varieties, the Traditional Basmati rice varieties which are rich in nutrition values and aroma are considered as the premium class and hence most of these rice varieties are being exported to other countries. In the present study, three hundred and fifty (350) Basmati rice varieties were collected from various super markets and retail outlets across India which were evaluated for allelic behavior using 10 SSR markers. According to UK CoP, only 75 sample qualified out of 350 samples. A total of 77.12% of the rice were Basmati varieties including varieties like Pusa Basmati 52%, followed by 28% of Pusa Basmati 1121. Surprisingly, we could not detect any Traditional Basmati rice portions either partially or completely. Very limited number of brands have 100% Basmati rice, without any adulteration in them. Our findings demonstrate the absence of Traditional Basmati rice in the Indian market despite of being the largest producer of the same.
Wear in Progress: How Third Body Flow Controls Surface Damage
Authors: Bouillanne Olivier , Mollon Guilhem , Saulot Aurélien , Descartes Sylvie , Serres Nathalie , Chassaing Guillaume , Demmou Karim
Published: February 2024

Mechanical contacts in dry conditions are often characterized by an interfacial layer called “third body”, which generally originates from the degradations of the surfaces, but which can exhibit strongly different material properties. This layer is a direct consequence of past wear, but also exerts a control on the rate at which surfaces in contact will keep getting worn. A comprehensive understanding of mechanical contacts therefore relies on a theory describing the interplay between this sheared layer and the moving surfaces which confine it. In this paper, we make a step towards such a theory by quantitatively investigating the link between the flow regime of the third body and the mechanical loading it applies to the surfaces. For that purpose, a previously developed local model of solid flow based on the Multibody Meshfree Approach is employed, in order to simulate characteristic flow regimes identified in experiments. Typical stress concentration patterns endured by the surfaces are then described and quantified, and a simple damage model is used to demonstrate how such a model could lead to wear prediction. We demonstrate that agglomerated flow regimes are prone to enhance large and deep damaging of surfaces, while granular third body flows have a more limited and shallow damaging effect.
Prevalence of Anxiety, Depression, and Post-Traumatic Stress Disorder Among Omani Children and Adolescents Diagnosed with Cancer: A prospective cross-sectional study
Authors: Al-Saadi Laila , Chan Moon Fai , Sabahi Amal Al , Kendi Jalila Al , Mashaikhi Nawal Al , Sumri Hana Al , Al-Fahdi Amal , Al-Azri Mohammed
Published: February 2024

Background
Children and adolescents diagnosed with cancer often experience psychological distress, encompassing anxiety, depression, and post-traumatic stress disorder (PTSD). This study aimed to evaluate the prevalence of these conditions among Omani children and adolescents diagnosed with cancer, alongside identifying contributing factors.
Methods
A prospective cross-sectional study was conducted from October 2021 to June 2023 among a cohort of Omani children and adolescents (6–18 years old) diagnosed with cancer at three primary cancer referral centres in Oman. Validated Arabic-language versions of the Screen for Child Anxiety Related Disorders, the Center for Epidemiologic Studies Depression Scale for Children, and the Impact of Event Scale-Revised instruments were used to assess symptoms of anxiety, depression, and PTSD, respectively. An initial assessment (T1) was undertaken within the first 3 months of diagnosis, followed by a second assessment (T2) 3–6 months later.
Results
Of 113 eligible participants, 101 agreed to participate in the study (response rate: 95.6%), with 92 (91.0%) completing both assessments and included in the final analysis. Prevalence rates of anxiety, depression, and PTSD decreased from 43.5%, 56.5%, and 32.6%, respectively, at T1, to 38.0%, 35.9%, and 23.9% at T2. All average scores were below diagnostic cut-off points, except for the depression score at T1. Anxiety and depression scores decreased significantly (p = 0.043 and 0.001, respectively) between T1 and T2, as did the overall prevalence of depression (p = 0.004). At T1, linear regression analysis showed significant correlations between anxiety scores and the child’s age and PTSD score (p < 0.05); these variables were also correlated with depression scores (p ≤ 0.001). At T2, significant correlations were observed between anxiety scores and the child’s age and PTSD scores (p < 0.001). At both T1 and T2, anxiety, depression, and PTSD scores remained significantly correlated (p < 0.001).
Conclusions
Omani children and adolescents recently diagnosed with cancer exhibit a high prevalence of anxiety, depression, and PTSD over time. Age-appropriate communication, ongoing support, and mental health services are recommended to help this patient group cope with their diagnosis and manage their emotional wellbeing. There is a need for future research to determine the effectiveness of specific psychological interventions in reducing the frequency of these disorders.
Machine Learning-Based Prediction of Post-Induction Hypotension: Identifying Risk Factors and Enhancing Anesthesia Management
Authors: Ming Chen , Zhang Dingyu
Published: February 2024

Background: Post-induction hypotension (PIH) increases surgical complications including myocardial injury, acute kidney injury, delirium, stroke, prolonged hospitalization, and endangerment of the patient's life. Machine learning is an effective tool to analyze large amounts of data and identify perioperative complication factors. This study aims to identify risk factors for PIH and develop predictive models to support anesthesia management.
Methods: A dataset of 5406 patients was analyzed using machine learning methods. Logistic regression, random forest, XGBoost, and neural network models were compared. Model performance was evaluated using the area under the receiver operating characteristic curve (AUROC), calibration curves, and decision curve analysis (DCA).
Results: The logistic regression model achieved the highest AUROC of 0.74 (95% CI, 0.71 - 0.77), indicating good discrimination. Calibration curves demonstrated satisfactory calibration for the logistic regression and random forest models. DCA revealed that the logistic regression model had the highest clinical benefit. The logistic regression model showed the best performance in predicting PIH and was selected as the final predictive model. Baseline blood pressure, age, sex, type of surgery, platelet count, and certain anesthesia-inducing drugs were identified as important features.
Conclusions: This study provides a valuable tool for personalized preoperative risk assessment and customized anesthesia management, allowing for early intervention and improved patient outcomes. Integration of machine learning models into electronic medical record systems can facilitate real-time risk assessment and prediction.
A Green, Facile, and Practical Preparation of Capsaicin Derivatives with Thiourea Structure
Authors: Chen Lina , Gao Zhenhua , Zhang Ye , Dai Xiandong , Meng Fanhua , Guo Yongbiao
Published: February 2024

A green, facile, and practical synthetic method of capsaicin derivatives with thiourea structure is developed by using an automated synthetic system, leading to a series of capsaicin derivatives with various electronic properties and functionalities in good to excellent yields.
Effects of Partially/Masked Face on the Personality Identifying: Self-Multimodal Fusion Consideration
Authors: Esmail Anter , El-Bendary Mohsen A. M. , Aboshosha Ashraf , El-Tokhy M. , Haggag Ayman
Published: February 2024

Due to the essential using of mask face in various fields and critical situations, there is urgent need to develop techniques for identifying personality to be more effective in presence the mask face. Also, Muslim women who wear Higab, they suffer from the traditional identifying processes. Facial recognition techniques have become ineffective with face mask. In this research, the technique of identifying the personality through the face with the mask was proposed by making a fusion between both the original face and part of the face, using Score fusion and features fusion. The research presented an extensive study of the effect of the mask on the difficulty of recognizing the face and changing the facial features. The research used more than one tool to extract the features of a face image with a mask, and a group of classification tools to identify the personality more accurately. More than one extraction tool has been combined to increase the classification accuracy. The different feature extracting of voice and masked face images are used with employing the various classifiers such as the Support Vector Machine (SVM), K-Nearest Neighbours (KNN), Gaussian Mixture Model (GMM) and Artificial Neural Network (ANN) tools. The simulation experiments results prove the superiority of score based fusion.
Changes in bone microstructural characteristics and the position of condyle head after orthognathic surgery with or without condylar resorption
Authors: Miyagawa Kazuaki , Arikawa Chihiro , Hayashi Koichi , Seki Soju , Yokota Yusuke , Harada Kazuma , Tanaka Susumu , Isomura Emiko Tanaka
Published: February 2024

Condylar resorption occurs in some cases after orthognathic surgery, and the risk factors associated with postoperative condylar head resorption have been extensively described. Nevertheless, even in cases with a combination of risk factors, postoperative condylar resorption may not appear. This study analyzed the microstructure and three-dimensional positional change of the condylar bone via imaging in patients who have undergone bimaxillary orthognathic surgery to determine whether the microstructure differs between patients with and without postoperative condylar resorption. Among asymptomatic patients who underwent bimaxillary surgery between April 2021 and March 2022 at our department, the bone microstructure of 17 patients was analyzed, limited to “female,” “skeletal Class II,” and “high-angle cases,” which are known risk factors for mandibular head resorption. Multidetector computed tomography was performed on these patients before and 6 months after surgery, and the bone microstructure of the condylar head was compared with the three-dimensional positional changes of the condylar bone and the proximal bony fragments according to whether the condylar head was resorbed after surgery using the bone morphology software TRI/3D-BON. Patients with condylar bone abnormalities before surgery and those with high trabecular bone density can develop postoperative resorption if the condyle is misaligned during surgery.
Transgenic Tobacco Plants Overexpressing a wheat Salt Stress Root Protein (TaSSRP) Exhibit Enhanced Tolerance to Heat Stress
Authors: Azameti Mawuli K. , N Tanuja , Kumar Satish , Rathinam Maniraj , Imoro Abdul-Wahab M. , Singh P. K , Gaikwad Kishor , Sreevat Rohini , Dalal Monika , Arora Ajay , Rai Vandna , Padaria Jasdeep C.
Published: February 2024

Heat stress is a detrimental abiotic stress that limits the development of many plant species and is linked to a variety of cellular and physiological problems. In this study, gene TaSSRP from the heat stress-tolerant wheat genotype Raj 3765 was functionally validated in transgenic tobacco for heat stress tolerance. The Relative Water Content (RWC), total chlorophyll content, and Membrane Stability Index (MSI) of the seven distinct transgenic lines (T0 − 2, T0 − 3, T0 − 6, T0 − 8, T0 − 9, T0 − 11, and T0 − 13), increased in response to heat stress. Despite the fact that the same tendency was detected in wild-type (WT) plants, changes in physio-biochemical parameters were greater in transgenic lines than in WT plants. The expression analysis revealed that the transgene TaSSRP expressed from 1.00 to 1.809 folds in different lines in the transgenic tobacco plants. The gene TaSSRP offered resistance to heat stress in Nicotiana tabacum, according to the results of the study. These findings could help to improve our knowledge and understanding of the mechanism underlying thermotolerance in wheat, and the novel identified gene TaSSRP could be used in generating wheat varieties with enhanced tolerance to heat stress.
Frontal Epidural Schwannoma: case report and review of the literature
Authors: Li Jiaqi , Shi Xinkang , Zhou Manxin , Tang Tao , Ye Feng , Liu Yi
Published: February 2024

Background：Schwannomas that occur in the brain and spinal cord parenchyma are very rare. Here, we have identified a rare case of epidural schwannoma and reviewed the reported cases in the literature.
Case presentation：A 21-year-old woman has a slowly growing, 3-centimeter sized mass in the frontal area of her head. Radiography shows a space occupying lesion in the left frontal epidural space, and the tumor has penetrated the skull. We performed a complete surgical excision of the tumor, during which the tumor was seen to pass through the skull and tightly adhere to the outer layer of the dura mater. Postoperative histopathology confirmed a schwannoma. The patient was discharged without any neurological defects.
Conclusion: Although it is difficult to distinguish the nature of intracranial epidural space occupying lesions pre-operation, it broadens the scope of epidural diseases. It is important to include epidural schwannoma in differential diagnosis when the patient is young and/or the tumor lacks the dural tail sign.
A GIS Based Approach to Identify Potential Aquaculture Site in Cachar District of Assam, India
Authors: B Mohammed Imthathullah , Kumar Avinash
Published: January 2024

This study briefly discusses about the present condition of aquaculture in the cachar district of Assam province in India and aids in the development of aquaculture production in the district by identifying the best suitable location for the pond culture technique. The main indent of this study is to highlight the role of Geographical Information System (GIS) and Remote Sensing (RS) in identifying the Suitable areas for aquaculture in cachar district of Assam. Satellite images obtained from LANDSAT-8, Sentinel-2B, and Space Shuttle Radar Topographic Mission (SRTM) were used in this Study. Decision Support System (DSS) methods were utilized for calculation of suitable sites. DSS was used to delineate areas. It was encountered by comparing the DSS models with the spatio-temporal images of Google Earth that the anticipated area exhibits the presence of available ponds, confirming the demarcation is reasonable. It was predicted that about 5.16% of the total land area of 3786 km2 is most suitable for aquaculture by the DSS methods. It has also predicted that about 15.2% of the of the area is moderately suitable for Aquaculture. It is also found that the hilly regions of north and eastern region of the district is not suitable for aquaculture. The study demonstrated the significance of integrating remote sensing, GIS, and qualitative data selecting appropriate sites for the development of aquaculture ponds and the significance of being an effective instrument for professionals to establish strategic plans for aquaculture development.
A novel ACE inhibitory peptide from Pelodiscus sinensis Wiegmann meat
Authors: Liu Huayu , Sun Xueqin , Zhang Xinrui , Zhang Miao , Wang Xianyou , Liao Pengying , Jun Chen
Published: January 2024

Pelodiscus sinensis meat is a nutritional food and tonic with angiotensin-converting enzyme (ACE) inhibitory activities. To identify the bioactive substances responsible, several bioinformatics methods were integrated to enable a virtual screening for bioactive peptides in proteins identified within a water-soluble protein fraction of Pelodiscus sinensis meat by Shotgun proteomics. The peptides were generated from the identified proteins by in silico proteolysis using six proteases. A comparison of the numbers of proteins suitable for digestion with each enzyme and the iBAQ (intensity-based absolute quantification) values for these proteins revealed that bromelain and papain were the most suitable proteases for this sample. Next, the water solubility, toxicity, and ADMET (absorption/ distribution/ metabolism/ excretion/ toxicity) properties of these peptides were evaluated in silico. Finally, a novel ACE inhibitory peptide IEWEF with an IC50 value of 42.34 µM was identified. The activity of the synthesized peptide was verified in vitro, and it was shown to be a non-competitive ACE inhibitor. Molecular docking revealed that IEWEF could tightly bind to ACE, C-ACE, and N-ACE with energies of-8.9,-9.4, and-8.7 kJ·mol-1 , respectively. These results provide evidence that bioactive peptides in the water-soluble protein fraction account for (at least) some of the ACE inhibitory activities observed in Pelodiscus sinensis meat. Furthermore, our research provides a workflow for the efficient identification of novel ACE inhibitory peptides from complex protein mixtures.
MRI and pathology comparisons in Rasmussen’s Encephalitis: A multi-institutional examination of hemispherotomy outcomes relative to imaging and histological severity
Authors: Doherty Alexander , Knudson Kathleen , Fuller Christine , Leach James , Wang Anthony , Marupudi Neena , Han Rowland , Tomko Stuart , Ojemann Jeff , Smyth Matt , Mangano Francesco , Skoch Jesse
Published: February 2024

Purpose
Rasmussen encephalitis (RE) is a very rare chronic neurological disorder of unilateral inflammation of the cerebral cortex. Hemispherotomy provides the best chance at achieving seizure freedom in RE patients, but with significant risks and variable long-term outcomes. The goal of this study is to utilize our multicenter pediatric cohort to characterize if differences in pathology and/or imaging characterization of RE may provide a window into postoperative seizure outcomes, which in turn could guide decision making for parents and healthcare providers.
Methods
This multi-institutional retrospective review of medical record, imaging, and pathology samples was approved by each individual institution’s review board. Data was collected from all known pediatric cases of periinsular functional hemispherotomy from the earliest available electronic medical records. Mean follow up time was 4.9 years. Clinical outcomes were measured by last follow up visit using both Engel and ILAE scoring systems. Relationships between categorical and continuous variables were analyzed with Pearson correlation values.
Results
27 patients met study criteria. No statistically significant correlations existed between patient imaging and pathology data. Pathology stage, MRI brain imaging stages, and a combined assessment of pathology and imaging stages showed no statistically significant correlation to post-operative seizure freedom rates. Hemispherectomy Outcome Prediction Scale scoring demonstrated seizure freedom in only 71% of patients receiving a score of 1 and 36% of patients receiving a score of 2 which were substantially lower than predicted.
Conclusions
Our analysis did not find evidence for either independent or combined analysis of imaging and pathology staging being predictive for post peri-insular hemispherotomy seizure outcomes, prompting the need for other biomarkers to be explored. Our data stands in contrast to the recently proposed Hemispherectomy Outcome Prediction Scale and does not externally validate this metric for an RE cohort.
Laser irradiation and pomegranate peel extract as novel trends to preserve the strawberry quality characteristics
Authors: Elsayed Nesren , Elkashef Hany , Ahmed Abd El-Rahman , Hassan Helmy , Ali Shaimaa R.
Published: February 2024

The present study aimed to explore the influence of laser irradiation and coating with chitosan and pomegranate peel extract on the physico-chemical, weight loss, firmness, functional, microbiological, color, and sensory characteristics of strawberry fruits during fifteen days of cold storage. Four treatments of strawberry were treated with laser irradiation for 6 min. The second, third, or fourth group was coated with chitosan, pomegranate peel extract (PPE), or mixture of chitosan and PPE at ratio 1:1. Compared to untreated strawberries, the exposure to laser radiation decreased the weight loss of strawberries by 43.44%. Also, the laser irradiation reduced the negative effect of storage on the total phenolic content, anthocyanin, ascorbic acid, and antioxidant ability of strawberry. The exposure of strawberry to laser reduced the counts of fungi and psychrotrophic bacteria and exhibited the positive effect on the color and sensory attributes. The coating with PPE and chitosan enhanced the positive effect of laser irradiation on the functional and quality properties of strawberry during cold storage. Hence, it can be concluded that laser irradiation and coating with PPE may be applied as novel techniques for the preservation of strawberry properties during storage period.
Role of SYT11 in human pan-cancer using comprehensive approaches
Authors: Noh Kyunghee , Yoo Wonbeak , Park Kyung Chan
Published: February 2024

Background
Synaptotagmin 11 (SYT11) plays a pivotal role in neuronal vesicular trafficking and exocytosis. However, no independent prognostic studies have focused on various cancers. In this study, we aimed to summarize the clinical significance and molecular landscape of SYT11 in various tumor types.
Methods
Using several available public databases, we investigated abnormal SYT11 expression in different tumor types and its potential clinical association with prognosis, methylation profiling, immune infiltration, gene enrichment analysis, and protein–protein interaction analysis, and identified common pathways.
Results
TCGA and Genotype-Tissue Expression (GTEx) showed that SYT11 was widely expressed across tumor and corresponding normal tissues. Survival analysis showed that SYT11 expression correlated with the prognosis of seven cancer types. Additionally, SYT11 mRNA expression was not affected by promoter methylation, but regulated by certain miRNAs and associated with cancer patient prognosis. Moreover, aberrant SYT11 expression was significantly associated with immune infiltration. Pathway enrichment analysis revealed that the biological and molecular processes of SYT11 were related to clathrin-mediated endocytosis, Rho GTPase signaling, and cell motility-related functions.
Conclusions
Our results provide a clear understanding of the role of SYT11 in various cancer types and suggest that SYT11 may be of prognostic and clinical significance.