bluuebunny/crossref_metadata_2025 huggingface dataset:
Protection properties of stuffed corrugated sandwich structures under hypervelocity impact: Numerical simulation
Authors: Zhou Hao , Guo Rui , Liu Rongzhong
Published: March 2017

The stuffed corrugated sandwich structure was proposed for the application in the protection of the spacecraft against orbital debris. In order to investigate the protection properties of the stuffed corrugated sandwich structure under hypervelocity impact, numerical simulations were carried out to analyze the impact characteristics. The hypervelocity impact process was presented and the properties such as shock waves propagation, energy absorption, and expansion of the debris cloud were discussed; corresponding properties of mass equal Whipple structure under impact were analyzed for comparison. The results illustrate the protection mechanism of the stuffed corrugated sandwich subject to hypervelocity impact and show that it has superior protection performance to monolithic plate, which prove that the stuffed corrugated sandwich structure has potentially broad application prospect in the field of spacecraft protection against the orbital debris. The research can provide reference for the design of protection shield of the spacecraft.
Leptomeningeal Carcinomatosis in Gastric Cancer: A Therapeutical Challenge
Authors: Vergoulidou Maria
Published: March 2017

Leptomeningeal carcinomatosis (LC) is a rare and mainly secondary site of metastasis in solid tumors. In gastric cancer (GC), it is associated with a devastating prognosis, lacking an efficient and standardized treatment approach. We report a case of primary manifestation of LC due to metastatic GC with rapid deterioration and refractory course to conventional and intrathecal chemotherapy. We review the literature and discuss the therapeutic challenges.
Spinal cord lesions: A modest contributor to diagnosis in clinically isolated syndromes but a relevant prognostic factor
Authors: Arrambide Georgina , Rovira Alex , Sastre-Garriga Jaume , Tur Carmen , Castilló Joaquín , Río Jordi , Vidal-Jordana Angela , Galán Ingrid , Rodríguez-Acevedo Breogán , Midaglia Luciana , Nos Carlos , Mulero Patricia , Arévalo Maria Jesús , Comabella Manuel , Huerga Elena , Auger Cristina , Montalban Xavier , Tintore Mar
Published: March 2017

Background:

The usefulness of performing a spinal cord (SC) magnetic resonance imaging (MRI) in all clinically isolated syndromes (CIS) is controversial.

Objective:

To assess the value of SC lesions for predicting multiple sclerosis (MS) diagnosis and disability accrual in CIS.

Methods:

Concerning SC lesions and MS diagnosis (2010 McDonald), adjusted Cox regression analyses were performed in increasingly specific CIS groups: all cases ( n = 207), non-SC CIS ( n = 143), non-SC CIS with abnormal brain MRI ( n = 90) and non-SC CIS with abnormal brain MRI not fulfilling 2010 MS ( n = 67). For the outcome Expanded Disability Status Scale (EDSS) ≥3.0, similar analyses were performed in all cases ( n = 207), non-SC CIS ( n = 143) and SC CIS ( n = 64). Performance at 2 years was assessed for all outcomes.

Results:

The presence of SC lesions increased MS risk 2.0–2.6 times independently of factors like brain lesions. If considering lesion number, the risk ranged from 1.6 to 2.1 for one lesion to 2.4–3.3 for ≥2. SC lesions increased the short-term disability risk around fivefold, better demonstrated in non-SC CIS. SC lesions were very specific for evolution to MS and showed very high sensitivity for EDSS ≥3.0.

Conclusion:

SC lesions are independent predictors of MS in all CIS and contribute to short-term disability accrual. SC MRIs in CIS could be useful to estimate their prognosis.
Ankylosing spondylitis and spinal trauma – with an emphasis on the role of radiology
Authors: Tyrrell Prudencia , Chowdhury J Roy
Published: March 2017

Diagnosis of spinal injury in a patient with chronic ankylosing spondylitis can be challenging. Minor insult can result in an unstable three-column injury which may be subtle. Spinal deformity, osteoporosis and limited mobility are associated with difficulty in positioning patients for imaging studies, including radiography and both computed tomography and magnetic resonance imaging. It is important to maintain a high index of suspicion of fracture, avoid forced neck extension during radiological imaging, and to consider whole spine imaging in these patients. Other causes of neurological symptoms simulating potential spinal injury are also briefly addressed.
Micro-slip control and torque estimation for dual clutch transmission
Authors: Zhou Bin , Lu Tongli , Zhang Jianwu , Hao Hongtao
Published: March 2017

Clutch micro-slip is significant in improving the performance of dual clutch transmission. Unlike with the conventional lockup control strategy, this research designs a novel controller to enable a desired micro-slip on clutch at the end of clutch engagement. Prior to the design, an extended Kalman filter is proposed to estimate the drive shaft torque based on an estimation model. The controller design is using the pole placement method based on the clutch slip dynamics; its input is calculated according to the estimated drive shaft torque, the engine torque, and the error between the actual slip and desired micro-slip, which realizes a closed-loop feedback control to ensure the control performance. The controller is validated by simulation works, and the results show that the clutch micro-slip is stable and robust.
Positive Narrative Therapy for an Unspecified Eating Disorder: A Child Case Report
Authors: Vescovelli Francesca , Albieri Elisa , Ruini Chiara
Published: March 2017

A new sequential multicomponent treatment (cognitive behavioral therapy followed by well-being-enhancing narrative strategies) was applied for an unspecified eating disorder in a 10-year-old boy for reducing symptoms and improving well-being. Both distress and well-being were assessed with self and observer ratings at baseline, posttreatment, and 3-, 6-, 12-month follow-up. An ABA design was used and reliable change indexes were calculated as outcome measures. This new sequential psychotherapeutic approach, which integrated standard cognitive behavioral therapy with narrative strategies addressed at promoting well-being in a child patient diagnosed with an unspecified eating disorder, was able to reduce symptoms and to foster his resources and positive behaviors. The patient himself, his parents, and teachers confirmed these improvements. This case report shows the clinical usefulness of a new sequential psychotherapeutic approach for treating an unspecified eating disorder in a child. It provides psychotherapists with relevant clinical implications concerning the emotional and interpersonal dimensions involved in this disabling condition.
The Percentage of Supported Employees With Significant Disabilities Who Would Earn More in Sheltered Workshops
Authors: Cimera Robert Evert
Published: March 2017

This study examined the percentage of 21,257 supported employees served by 74 state-federal vocational rehabilitation agencies in 2013 who would have earned more wages in sheltered workshops than in the community. It found that the overwhelming majority of supported employees earned more in their communities at all wage comparison points; however, substantial differences in wages were identified according to the participant’s disability type, occupation, vocational rehabilitation agency, and the region in which they lived.
Is There a Dose–Response Relationship of Cement Volume With Cement Leakage and Pain Relief After Vertebroplasty?
Authors: Fu Zhiyi , Hu Xiaopeng , Wu Yujie , Zhou Zihui
Published: March 2017

The aim of this study was to determine if there were dose–response relationships of cement volume with cement leakage and pain relief after percutaneous vertebroplasty (PVP) for osteoporosis vertebral compression fractures (OVCFs). We collected the patient and procedural characteristics on 108 patients with OVCFs in our hospital who received PVP. Univariate and multivariate analyses were performed to explore the relationships between these potential influential variables and cement leakage and pain relief at 1 month postoperatively. Multivariate linear and logistic regression analyses were conducted with the pain score reduction and the bone cement leakage as dependent variables and the potential risk factors as independent variables, respectively. The results showed that the independent risk factors for the pain relief were the cement volume injected and fracture age, and for bone cement leakage were the cement volume injected and low-viscosity cement. In conclusion, the present study indicated that there were positive dose–response correlation relationships of cement volume with the incidence of cement leakage and the degree of pain relief after PVP, respectively. Thus, the cement should be injected into the vertebrae as much as possible during the PVP procedure.
Abnormal Brain Connectivity Spectrum Disorders Following Thimerosal Administration
Authors: Geier David A. , Kern Janet K. , Homme Kristin G. , Geier Mark R.
Published: March 2017

Background:

Autism spectrum disorder (ASD), tic disorder (TD), and hyperkinetic syndrome of childhood (attention deficit disorder [ADD]/attention deficit hyperactivity disorder [ADHD]) are disorders recently defined as abnormal connectivity spectrum disorders (ACSDs) because they show a similar pattern of abnormal brain connectivity. This study examines whether these disorders are associated with exposure to thimerosal, a mercury (Hg)-based preservative.

Methods:

A hypothesis testing case-control study evaluated the Vaccine Safety Datalink for the potential dose-dependent odds ratios (ORs) for diagnoses of ASD, TD, and ADD/ADHD compared to controls, following exposure to Hg from thimerosal-containing Haemophilus influenzae type b vaccines administrated within the first 15 months of life. Febrile seizures, cerebral degeneration, and unspecified disorders of metabolism, which are not biologically plausibly linked to thimerosal, were examined as control outcomes.

Results:

On a per 25 μg Hg basis, cases diagnosed with ASD (OR = 1.493), TD (OR = 1.428), or ADD/ADHD (OR = 1.503) were significantly ( P < .001) more likely than controls to have received increased Hg exposure. Similar relationships were observed when separated by gender. Cases diagnosed with control outcomes were no more likely than controls to have received increased Hg exposure.

Conclusion:

The results suggest that Hg exposure from thimerosal is significantly associated with the ACSDs of ASD, TD, and ADD/ADHD.
A dual positive and negative regulation of monocyte activation by leukocyte Ig-like receptor B4 depends on the position of the tyrosine residues in its ITIMs
Authors: Park Mijeong , Liu Robert W , An Hongyan , Geczy Carolyn L , Thomas Paul S , Tedla Nicodemus
Published: March 2017

The leukocyte Ig-like receptor B4 (LILRB4) is an inhibitory cell surface receptor, primarily expressed on mono-myeloid cells. It contains 2 C-type Ig-like extracellular domains and a long cytoplasmic domain that contains three intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Data suggest that LILRB4 suppresses Fc receptor-dependent monocyte functions via its ITIMs, but relative contributions of the three ITIMs are not characterised. To address this, tyrosine (Tyr) residues at positions 337, 389 and 419 were single, double or triple mutated to phenylalanine and stably transfected into a human monocytic cell line, THP-1. Intact Tyr389 was sufficient to maximally inhibit FcγRI-mediated TNF-α production in THP-1 cells, but, paradoxically, Tyr337 significantly enhanced TNF-α production. In contrast, bactericidal activity was significantly enhanced in mutants containing Tyr419, while Tyr337 markedly inhibited bacteria killing. Taken together, these results indicate that LILRB4 might have dual inhibitory and activating functions, depending on the position of the functional tyrosine residues in its ITIMs and/or the nature of the stimuli.
Long-term use of benzodiazepines in older patients in Germany: a retrospective analysis
Authors: Jacob Louis , Rapp Michael A. , Kostev Karel
Published: March 2017

Background:

The purpose of this study was to analyze the prevalence of long-term benzodiazepine use in older adults treated in general and neuropsychiatric practices in Germany.

Methods:

This study included 32,182 patients over the age of 65 years who received benzodiazepine prescriptions for the first time between January 2010 and December 2014 in general and neuropsychiatric practices in Germany. Follow up lasted until July 2016. The main outcome measure was the proportion of patients treated with benzodiazepines for >6 months.

Results:

The proportion of patients with benzodiazepine therapy for >6 months increased with age (65–70 years: 12.3%; 71–80 years: 15.5%; 81–90 years: 23.7%; >90 years: 31.6%) but did not differ significantly between men (15.5%) and women (17.1%). The proportion of patients who received benzodiazepines for >6 months was higher among those with sleep disorders (21.1%), depression (20.8%) and dementia (32.1%) than among those with anxiety (15.5%). By contrast, this proportion was lower among people diagnosed with adjustment disorders (7.7%) and back pain (3.8%).

Conclusion:

Overall, long-term use of benzodiazepines is common in older people, particularly in patients over the age of 80 and in those diagnosed with dementia, sleep disorders, or depression.
Growth differentiation factor-15 is a predictor of important disease outcomes in patients with COPD
Authors: Husebø Gunnar R. , Grønseth Rune , Lerner Lorena , Gyuris Jeno , Hardie Jon A. , Bakke Per S. , Eagan Tomas M.
Published: March 2017

Increased levels of growth differentiation factor-15 (GDF15) are associated with cachexia, cardiovascular disease and all-cause mortality. The role of GDF15 in chronic obstructive pulmonary disease (COPD) is unknown.

The study included 413 patients with COPD from the Bergen COPD Cohort Study. All patients had a forced expiratory volume in 1 s (FEV1) <80% predicted, a FEV1to forced vital capacity (FVC) ratio <0.7 and a history of smoking. Spirometry, fat free mass index, blood gases and plasma GDF15 were measured at baseline. Patients were followed for 3 years regarding exacerbations and changes in lung function, and 9 years for mortality. Yearly exacerbation rate, survival and yearly change in FEV1/FVC were evaluated with regression models.

Median plasma GDF15 was 0.86 ng·mL−1(interquartile range 0.64–1.12 ng·mL−1). The distribution was not normal and GDF15 was analysed as a categorical variable. High levels of GDF15 were associated with a higher exacerbation rate (incidence rate ratio 1.39, 95% CI 1.1–1.74, p=0.006, adjusted values). Furthermore, high levels of GDF15 were associated with higher mortality (hazard ratio 2.07, 95% CI 1.4–3.1, p<0.001) and an increased decline in both FEV1(4.29%versus3.25%) and FVC (2.63%versus1.44%) in comparison to low levels (p<0.01 for both).

In patients with COPD, high levels of GDF15 were independently associated with a higher yearly rate of exacerbations, higher mortality and increased decline in both FEV1and FVC.
Impact of tumour thickness on survival after radical radiation and surgery in malignant pleural mesothelioma
Authors: de Perrot Marc , Dong Zhi , Bradbury Penelope , Patsios Demetris , Keshavjee Shaf , Leighl Natasha B. , Hope Andrew , Feld Ronald , Cho John
Published: March 2017

Tumour thickness was assessed to determine if this parameter could refine patients' selection for multimodality therapy in malignant pleural mesothelioma.

We reviewed 65 consecutive treatment-naïve malignant pleural mesothelioma patients undergoing surgery for mesothelioma after radiation therapy (SMART). Total tumour thickness was determined by measuring the maximal thickness on nine predefined sectors on the chest wall, mediastinum and diaphragm.

After a median follow-up of 19 months, 40 patients (62%) developed recurrence and 36 died (55%). Total tumour thickness, ranging between 2.4 and 21 cm (median 6.9 cm), correlated with tumour volume (p<0.0001, R2=0.29) and maximum standardised uptake value (p=0.006, R2=0.11). Total tumour thickness had a significant impact on overall survival and disease-free survival in univariate analysis. In multivariate analysis, total tumour thickness remained an independent predictor of survival (p=0.02, hazard ratio (HR) 1.12, 95% CI 1.02–1.23) and disease-free survival (p=0.01, HR 1.13, 95% CI 1.03–1.24) along with epithelial histologic subtype (p<0.0001, HR 0.25, 95% CI 0.13–0.50) and pN2 disease (p=0.03, HR 2.15, 95% CI 1.07–4.33). Diaphragmatic tumour thickness correlated best with time to recurrence (p=0.002, R2=0.22) and time to death (p=0.003, R2=0.2).

The impact of tumour thickness on survival and disease-free survival independent of histologic subtypes and nodal disease is extremely encouraging. This parameter could potentially be used to refine the clinical staging of malignant pleural mesothelioma and optimise patient selection for radical treatment.
Experiences of mobility for people living with rheumatoid arthritis who are receiving biologic drug therapy: implications for podiatry services
Authors: Sanders Lucy , Donovan‐Hall Margaret , Borthwick Alan , Bowen Catherine J.
Published: March 2017

Background

Despite significant advancements in new treatment modalities for rheumatoid arthritis with biological therapies, foot complications remain a disabling and common feature of the disease. In this study the aim was to explore and describe the personal experiences of people with rheumatoid arthritis in receipt of biologic treatments in a bid to understand the impact of this form of medication on their mobility.

Methods

An interpretative phenomenological analysis (IPA) was undertaken to explore in depth the individual experience of rheumatoid disease through personal accounts of the patient journey spanning both ‘before’ and ‘after’ the instigation of biologic therapy. A purposive sampling strategy was adopted and in‐depth semi structured interviews used to facilitate rich, detailed interview data exploring the lived experiences of individuals undertaking biological therapy and the changes to mobility experienced as a result. Thematic analysis was employed with an IPA framework to identify key meanings, and report patterns within the data.

Results

Five people with rheumatoid arthritis participated in the study. The mean disease duration was 20.2 years (range: 6 ‐32) and all were being treated with biologic therapies. Four key themes emerged from the data: 1) Life before biologic treatment, depicted in accounts as a negative experience characterised by painful and disabling symptoms and feelings of hopelessness. 2) Life with biologic treatment, often experienced as a life changing transition, restoring function and mobility and offering renewed hope. 3) Sense of self, in which the impact of rheumatoid disease and the subsequent changes arising from biologic therapy reveal a profound impact on feelings of personal identity both pre and post biologic therapy; an effect of footwear on self‐image emerges as a dominant sub theme; 4) Unmet footcare needs were evident in the patient narrative, where the unrelenting if diminished impact of foot pain on mobility was viewed in the context of problematic access to foot health services.

Conclusion

Whilst the findings from this study mirror those within the existing literature, which report improvements in physical function related to biological therapy, foot problems clearly remained an unremitting feature of life for patients with rheumatoid disease, even when in receipt of biologics.
“I am anxious and desperate”: psychological experiences of women with infertility in The Greater Accra Region, Ghana
Authors: Donkor Ernestina S. , Naab Florence , Kussiwaah Deborah Y.
Published: March 2017

Background

Research has shown that infertility affects millions of couples worldwide. Infertility is considered one of the most difficult life experiences and can result in psychological consequences for couples, especially for women. The purpose of this study was to explore the psychological experiences of women with infertility.

Methods

A qualitative exploratory descriptive approach was used to conduct in-depth interviews. The psychological component of the bio-psychosocial model was used as a guiding framework to understand the experiences of women with infertility. Fourteen women were selected based on the purpose of the study and provided their informed consent, and were interviewed between November 2015 and January 2016. All the women were recruited from the Greater Accra Region of Ghana. Each interview lasted for 30 to 40 min. All interviews were audio taped, transcribed verbatim and analyzed using thematic content analysis.

Results

The findings from the study showed that women with fertility problems experienced many emotional difficulties such as loneliness, anxiety, depression, lack of concentration, worrying, and reduced sexual satisfaction.

Conclusions

Women in this study encountered psychological challenges and experienced emotional distress. Such women would benefit from psychological support such as counseling to help alleviate their psychological problems. These findings have implications for the care of women with infertility in Ghana.
In-line recognition of agglomerated pharmaceutical pellets with density-based clustering and convolutional neural network
Authors: Mehle Andraž , Likar Boštjan , Tomaževič Dejan
Published: March 2017

We present a method for recognition of agglomerates in images acquired during the coating process of pharmaceutical pellets. The pellets in the images are not perfectly dispersed, and it is often hard to differentiate between a random group of primary particles and a real agglomerate. The method utilizes a clustering-based image segmentation for candidate region detection and a convolutional neural network for classification of detected pellets to primary particles or agglomerates. We validated the performance of the method on real images of pharmaceutical pellets acquired during the coating process and achieved 93% classification accuracy.
From Modernity to Tradition: Zhu Ziqing's Chinese Literary Criticism
Authors: Chan Leonard Kwok Kou
Published: March 2017

Is “literary criticism” a foreign concept? What is the impact of the reception of literary criticism on the modern studies of Chinese literature? Zhu Ziqing's 朱自清 (1898–1948) conception of the function of literary criticism is illustrative of these questions. Zhu developed an interest in Western literary criticism before entering Tsinghua University, where he absorbed more ideas about Western literature. With the support of department head Yang Zhensheng 楊振聲 (1890–1956), he planned a new curriculum in 1928, in an attempt to make literature in his concept a subject as important as classical exegetical studies. From Zhu's curriculum planning, his research orientation, and how he tried to put his ideas into practice, we can observe the oppositional tension between the modern concept of literary criticism and the traditional philological approach of Chinese study. Through an examination of Zhu's academic role, this article explores the emergence of the concept of literary criticism in modern China. It will be compared and contrasted with the situation in the West, with an aim of giving a detailed analysis of the way literary criticism has become an essential part of modern Chinese literary study.
ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ МЕЛАТОНИНА В ТЕРАПИИ РАЗЛИЧНЫХ ПСИХИЧЕСКИХ РАССТРОЙСТВ (ОБЗОР ЛИТЕРАТУРЫ)
Authors: Hannanova Angelina Nailevna , Bykov Yuriy Vitalevich , Bekker Roman Aleksandrovich
Published: March 2017

Цель исследования: Обзор и обобщение существующих литературных данных о применении мелатонина в терапии различных психических расстройств, формулирование выводов о качестве доказательной базы для его применения, о перспективах его применения в терапии психических расстройств и перспективности дальнейшего его исследования в этом направлении.Методология проведения работы. Авторами был проведен поиск по публичным базам данных PubMed / MedLine / EmBASE / UpToDate с использованием ключевого слова melatonin в конъюнкции с ключевыми словами cognition, cognitive, mood disorders, affective disorders, insomnia, psychosis, schizophrenia, anxiety disorders. Найденные результаты подвергались сортировке в соответствии с критериями доказательности (РКИ, открытые проспективные исследования, сообщения серий случаев, единичных случаев, гипотетические предположения о возможной эффективности). Затем проводилось обобщение полученных данных.Результаты. Полученные нами в результате настоящего обзора литературы данные свидетельствуют о перспективности применения мелатонина в комплексной терапии диссомнических состояний, алкоголизма, тревожных и аффективных расстройств, шизофрении и других психозов, в лечении и профилактике таких побочных эффектов психофармакотерапии, как метаболический синдром, поздние дискинезии, акатизия, инсомния, а также о перспективности дальнейшего исследования мелатонина в этом направлении.Область применения результатов. Полученные нами результаты заслуживают широкого применения в психиатрии, наркологии и неврологии.
ИССЛЕДОВАНИЕ КАЧЕСТВА ЖИЗНИ ПАЦИЕНТОВ В РЕАБИЛИТАЦИОННОМ ПЕРИОДЕ ПОСЛЕ ХИМИЧЕСКОГО ПИЛИНГА
Authors: Kuznetsova Elena Sergeevna
Published: March 2017

В статье представлены данные о влиянии применения жидкостей с различным окислительно-восстановительным потенциалом в период реабилитации после косметологических процедур на качество жизни пациентов. Цель исследования: установить влияние жидкостей с различным окислительно-восстановительным потенциалом качество жизни пациентов в постпилинговом периоде. Пациентам была проведена процедура ретиноевого химического пилинга. При применении жидкостей с различным окислительно-восстановительным потенциалом осложнения в реабилитационном периоде после этой процедуры были значительно менее выраженными. Полученные данные характеризуют течение реабилитационного периода после химического пилинга при применении жидкостей с различным окислительно-восстановительным потенциалом как более благоприятное, с более высоким качеством жизни.
ЭПИДЕМИОЛОГИЧЕСКИЕ И КЛИНИКО-ЛАБОРАТОРНЫЕ ОСОБЕННОСТИ РАЗЛИЧНЫХ ВАРИАНТОВ ЛИМФОМ В РЕСПУБЛИКЕ ХАКАСИЯ ПО РЕЗУЛЬТАТАМ ИЗУЧЕНИЯ ПЕРВИЧНОЙ ЗАБОЛЕВАЕМОСТИ В 2014 Г.
Authors: Smirnova Olga Valentinovna , Shtygasheva Olga Vladimirovna , Kablukov Vitaly Sergeevich
Published: March 2017

Цель. Цель исследования – изучение эпидемиологических особенностей первичной заболеваемости лимфомами и основных диагностических показателей (наличие В-симптомов, стадия Ann – Arbor, статус по ECOG, лабораторные признаки, характерные зоны поражения, наличие экстранодальных очагов) при различных клинико-морфологических вариантах лимфом в Республике Хакасия по материалам ГБУЗ РХ «Клинического онкологического диспансера» за 2014 г.Метод или методология проведения работы. Исследование проведено методом ретроспективного анализа.Результаты. Выявлены следующие эпидемиологические особенности: чаще встречаются неходжкинские лимфомы (НХЛ); заболеваемость лиц мужского пола выше, чем женского; среди уточненных морфологических вариантов ЛГМ распространен нодулярный склероз и лимфоидное преобладание, среди НХЛ имеет наибольшее распространение диффузная неходжкинская лимфома; отмечено, что НХЛ чаще встречается у городского население. Установлены достоверно значимые различия по следующим показателям: возрастной критерий – для ЛГМ характерен возраст <60 лет, для НХЛ >60 лет; характерные зоны поражения – при ЛГМ чаще поражаются следующие группы лимфатических узлов: подмышечные, ворот печени, паракавальные, чревные (верхне-абдоминальные), паравертебральные (нижне-абдоминальные), и подвздошные.Область применения результатов. Организация здравоохранения, онкология, внутренние болезни.
ОСОБЕННОСТИ АДАПТАЦИИ КУРСАНТОВ ОБРАЗОВАТЕЛЬНЫХ ОРГАНИЗАЦИЙ ВЫСШЕГО ОБРАЗОВАНИЯ К ДЕЙСТВИЯМ В УСЛОВИЯХ ЧРЕЗВЫЧАЙНЫХ СИТУАЦИЙ
Authors: Shipilov Roman Mikhailovich , Sharabanova Irina Yuryevna , Zeinetdinova Olga Gennadievna , Kokurin Alexey Konstantinovich
Published: March 2017

Цель. Выявление особенностей адаптации курсантов, принимавших участие в мероприятиях по ведению аварийно-спасательных работ, к условиям чрезвычайных ситуаций.Материалы и методы. Исследование проводилось в период с 2012 года по 2015 год. В исследовании приняли участие 348 курсантов 4 года обучения образовательной организации высшего образования МЧС России. В ходе исследования применялся комплекс психологических исследований с помощью опросника травматического стресса И.О. Котенева и метода интервьюирования.Результаты. Деятельность курсантов образовательных организаций высшего образования МЧС России связанная с ведением аварийно-спасательных работ в зоне ЧС характеризуется опасностью и высоким риском, значительными психическими и энергетическими затратами. В представленной работе рассматриваются результаты исследования адаптации курсантов, принимавших участие в мероприятиях по ликвидации последствий ЧС.Заключение. В процессе ведения аварийно-спасательных работ в зоне ЧС курсанты получили реальный опыт действий по ликвидации последствий чрезвычайных ситуаций. Курсанты на практике увидели последовательность и этапность проведённых мероприятий, планы и возможные варианты ликвидации крупномасштабных ЧС. Увидели, как осуществля­ется работа и взаимодействие различных структур и подразделений МЧС. Курсанты получили возможность проверить себя и свою готовность к экстремальной ситуации и повысить свою стрессоустойчивость.Полученные данные в целом демонстрируют положительную динамику развития профессионально-значимых качеств личности, необходимых сотруднику ФПС ГПС в условиях чрезвычайных, экстремальных ситуациях.
ДИНАМИКА МОРФОФУНКЦИОНАЛЬНЫХ ПОКАЗАТЕЛЕЙ МАЛЬЧИКОВ 8–15 ЛЕТ г. НАБЕРЕЖНЫЕ ЧЕЛНЫ
Authors: Magsumov Timur Al’bertovich , Smirnova Alla Vital’evna , Khasanova Al’fiya Radifovna , Magsumova Raisa Al’bertovna
Published: March 2017

Целью данной работы было изучение динамики морфофункционального состояния мальчиков школьного возраста г. Набережные Челны.Метод или методология проведения работы. По унифицированной антропометрической методике исследованы основные морфофункциональные показатели 800 учащихся общеобразовательных школ 8–15 лет. Анализ проводился по возрастным группам с годовым интервалом, установленным по Мартину.Результаты. Исследование физического развития мальчиков 8–15 лет г. Набережные Челны показало, что нынешние школьники превосходят школьников 1980-х гг. по основным антропометрическим показателям. В функциональном состоянии сердечно-сосудистой системы выявлены негативные тенденции: более высокие показатели частоты сердечных сокращений и диастолического артериального давления. Во всех возрастных группах отмечено достоверное снижение мышечной силы кистей рук. Жизненная емкость легких у исследуемых в 9 и 10 лет достоверно выше, а в 12–15 – достоверно ниже, чем у их ровесников конца 1980-х гг.Область применения результатов. Полученные данные могут служить в качестве ориентиров для оценки физического развития отдельных детей или детских коллективов, позволяют разрабатывать систему мероприятий по профилактике отклонений в физическом развитии современных школьников, а также применяться для оценки эффективности оздоровительных мероприятий, что, несомненно, будет способствовать укреплению здоровья детского контингента.
Directions of Civil Service Institutional Transformation
Authors: Борщевский  , Borshchevskiy G.
Published: March 2017

The concepts of rational bureaucracy, New Public Management and Good Governance were studied. It is

indicated that wrongly assume that one of them is more progressive, because all concepts originally aimed

at the rationalization of the public service and subordination its own interests according the interests of

society.

A set of conditions for the participation of citizens in governance exists today. There are a networked

organization, a partnership, a production of public goods, and value of public interest. It is proved that in the

Concept of the Russian Federation civil service reform (2001) laid the modernization potential for building an

open and democratic public service.

We postulate the classification of the barriers and challenges that hinder the civil service reform, and we

formulate the growth points and the alternative transformation vectors. Then we consider the risks of each

alternative in the short, medium and long term, and how to overcome them. It is indicated that the priority

should be the harmonization of the legal framework for civil service and public sector.

In the first step is need the convergence of the legal content of civil service with other activities in the public

sector, and the renouncement the civil servants to serve to politicians, which is aimed at increasing their

personal responsibility. It is necessary to implement the new basic legal principle of targeting efforts of the

civil servants to achieve economic growth and improve the quality of citizens life.

In the next step a new phenomenon – the public service – should be formed. The new public service will

include the civil service, municipal service and the public sector organizations, as well as some other types

of organizations.

This requires some changes in the personnel policy: the formation of a single personnel reserve for the

entire public service, improving the qualification requirements for all public positions based on professional

specializations, and ensuring the effective public control. A systematic approach to the creation of the public

service will increase the efficiency of public institutions and their resilience in the face of global instability.

Our conclusions were tested in draft the Strategy of socio-economic development of Russia for the period

till 2030.
Steven Mann’s “Chaos Theory” and Corporate Governance
Authors: Савченко  , Savchenko A.
Published: March 2017

The article considers the problem of analysis of the external environment of the organization on the basis of

the views of Steven Mann’s “theory of controlled chaos”. The use of “chaos theory” allows us to re-evaluate

the dynamics of the external environment and to understand the nature of some processes in the world

market. “Chaos Theory” is not opposed to the theory of management, but complements it explaining the

nonlinearity of the environment and the individual causes of socio-economic viruses.
Intermediate results 2016 of a search study of translational diagnostic methods Mitochondrial dysfunction in patients with chronic myocardial ischemia and/or head Brain
Authors: Киреева Виктория , Kireeva Viktoriya , Усольцев Ю. , Usolcev Yu. , Капустенская Ж. , Kapustenskaya Zh. , Кожевникова Е. , Kozhevnikova E. , Зайка А. , Zayka A. , Апарцин Константин , Apartsin Konstantin
Published: March 2017

Purpose of the study. To rate prognostic properties of changes in mitochondrial DNA concentration in the blood plasma of patients with chronic cerebral ischemia and ischemic heart disease in relation to the disease and the effectiveness of the therapy. Materials and methods. The study involved patients suffering from coronary heart disease (CHD) and chronic cerebral ischemia (CCI) with stable and unstable atherosclerotic plaques, who have signed informed consent to the data processing within the framework of scientific research. The patients were admitted to the hospital for examination and treatment of CHD and CCI in Cardiology and Neurology Unit of the Hospital of ISC SB RAS. The subjects underwent laboratory and instrumental examination and analysis of the level of free circulating serum mitochondrial DNA by real-time PCR (copies/ml). The examination results considered as satisfactory were compared with the mtDNA levels before and after the treatment. Results. The average value of the mtDNA levels before and after the treatment in patients of neurological and cardiological profile were significantly different: 1 093 686 copies/ml vs 418 046 copies/ml, respectively (p = 0.02). Unlike women, men mtDNA levels statistically significantly (p = 0.03) decreased after the treatment. We revealed statistically significant differences in mtDNA level indicators before and after the treatment, depending on the definition of the series (p = 0.0010) for rank test Kruskal – Wallis test. The results of the proposed research will help to identify prognostic factors of destabilization of cell damage and plaques in endothelial dysfunction, atherosclerosis and its complications, to conduct clinical test of the method for predicting and diagnostics of cellular damage in chronic ischemia on a background of atherosclerosis.
Advantages of a personalized approach to the prevention and treatment of cardiovascular diseases in the staff of the INC Of the SBRAS
Authors: Киреева Виктория , Kireeva Viktoriya , Лифшиц Г. , Lifshic G. , Кох Н. , Koh N. , Усольцев Ю. , Usolcev Yu. , Апарцин Константин , Apartsin Konstantin
Published: March 2017

Purpose of the study. To test the functional associations of polymorphic variants of genes in the regulation of blood pressure and vascular tone in employees of the ISC SB RAS. Materials and methods. The study involved patients, employees of the ISC SB RAS, being under care of the outpatient clinic of the Hospital of the ISC SB RAS. During routine laboratory testing the patients were taken 2 ml of blood for genetic analysis and further molecular genetic study on “Hypertension”, “Endothelial dysfunction”, “Pharmacogenetics”, “Inflammatory response” panels. Results. In the analysis of 12 genes coding for key proteins of hormonal enzyme blood pressure regulation systems, polymorphism of CYP11B2 showed statistically significant correlation with the presence of arterial hypertension, which makes its further study promising. The presence of allele C showed protective significance in relation to the development of hypertension with OR = 0,247. When checking associations of functional polymorphic variants of genes, the products of which are involved in the regulation of vascular tone, with hypertension in patients younger than 50 years old we found association of T/T rs5443GNB3 genotype with the debut of hypertensive disease under the age of 50. The data obtained allow the doctor to choose the most personalized and effective safe drug from certain groups, as well as its dose for employees having passed molecular genetic testing. These data can reveal predisposition to the most widespread and socially significant diseases in the surveyed subjects and provide specific personalized recommendations for the prevention of these diseases.
Research Roundup
Authors: Winter George
Published: March 2017

George Winter provides an overview of recently published articles that may be of interest to practice nurses. Should you wish to look at any of the papers in more detail, a full reference is provided.
Setting up a nurture group
Authors: Freeman Garry
Published: March 2017

Garry Freeman presents a short guide to the practicalities and key challenges of setting up a secondary nurture group
Selecting Statistical Quality Control Procedures for Limiting the Impact of Increases in Analytical Random Error on Patient Safety
Authors: Yago Martín
Published: March 2017

BACKGROUND

QC planning based on risk management concepts can reduce the probability of harming patients due to an undetected out-of-control error condition. It does this by selecting appropriate QC procedures to decrease the number of erroneous results reported. The selection can be easily made by using published nomograms for simple QC rules when the out-of-control condition results in increased systematic error. However, increases in random error also occur frequently and are difficult to detect, which can result in erroneously reported patient results.

METHODS

A statistical model was used to construct charts for the 1ks and X/χ2 rules. The charts relate the increase in the number of unacceptable patient results reported due to an increase in random error with the capability of the measurement procedure. They thus allow for QC planning based on the risk of patient harm due to the reporting of erroneous results.

RESULTS

1ks Rules are simple, all-around rules. Their ability to deal with increases in within-run imprecision is minimally affected by the possible presence of significant, stable, between-run imprecision. X/χ2 rules perform better when the number of controls analyzed during each QC event is increased to improve QC performance.

CONCLUSIONS

Using nomograms simplifies the selection of statistical QC procedures to limit the number of erroneous patient results reported due to an increase in analytical random error. The selection largely depends on the presence or absence of stable between-run imprecision.
Ceremonial ‘Russian dress’ as a phenomenon of court culture
Authors: Amelekhina Svetlana A. , Green Daniel
Published: March 2017

Russian rulers introduced numerous dress reforms in the imperial period, transforming the appearance of state institutions and thus the image of Russia and its elite. This article traces the origins and development of ‘Russian dress’, a stylized version of female Russian folk costume introduced to the Russian court by Catherine the Great (1762–1796) and worn, in various forms, from the 1770s to 1917. We examine the symbolic role ‘Russian dress’ played in shaping the image of the ruler, Russia’s relationship with the West, and shifting notions of Russianness at home and abroad.
Performing Sand: A Case for the Abandonment of Video Documentation in Buddhist-Inspired Live Art
Authors: Clark Pema
Published: March 2017

Documenting performance in the context of practice-based research has become the standard protocol for the assessment of live work in the academy as permanent document and archive. In contrast, the practice of Buddhism recognizes impermanence as the central doctrine governing all conditioned existence. What happens when these two fields are combined? In addressing the dialectic inherent in documenting a field of performance art that relies on its doctrinal foundations to convey principles that video documentation renders redundant, I offer an alternative method of documentation as part of the creative process that keeps the work ‘live’ in the mind of the audience upon every subsequent engagement with the archive. Far from being a failure to document, Buddhist performance art demands a new approach to the documentation of performance.

The article includes a performance score inspired by my autobiographical performance artwork At Sea: 1980–2010.
Postfeminist ‘Islamophobia’: The Middle East is so 1980s in Sex and the City: The Movie 2
Authors: Richardson Niall
Published: March 2017

This article analyses how Sex and the City: The Movie 2 (King, 2010) represents a binary between style that is coded as ‘vintage’ and, therefore, desirable, and style that is depicted as ‘dated’ and identified as bad taste. Although this has been a dominant motif in both the Sex and the City series and first film (King, 2008), Sex and the City: The Movie 2 maps this distinction onto a West/Middle East binary. While everything Western (or, more precisely, everything NYC) is represented as stylish, the Middle East (and here it is Abu Dhabi that stands in for the Middle East) is depicted as dated and, the film suggests, trapped in the decade of the 1980s. Sex and the City: The Movie 2 develops many of the prejudices found in contemporary Western representations of the Middle East but articulates these through the motifs of fashion, consumerism and female sexuality. The article proposes that what is most offensive about Sex and the City: The Movie 2 is that it conflates all the social, cultural, political and, most importantly, religious differences that exist between secular New York and Muslim Abu Dhabi and reduces all of these issues to a simple question of style and knowing consumerism.
Gender and the ‘masquerade’ in James Joyce, Joan Riviere and Marlene Dietrich, 1925–30
Authors: Saunders Helen
Published: March 2017

My article, which begins by noting the fluke meeting between writer James Joyce and film star Marlene Dietrich in a Paris restaurant, considers the importance of masquerade and gender performativity in three texts of the late 1920s: an extract from Joyce’s final novel, Finnegans Wake, first published in 1925; Dietrich’s film, The Blue Angel (1930); and Joan Riviere’s psychoanalytic essay, ‘Womanliness as a masquerade’ (1929). After critically assessing the term ‘masquerade’ and Riviere’s reflections on it, I discuss the significance of Dietrich’s self-made costumes for The Blue Angel, arguing that she recognises the playful potential of the masquerade. Following this, I discuss the gender performativity of ALP, the heroine of Finnegans Wake, noting that her chapter of the novel shares with Dietrich’s and Riviere’s texts an emphasis on gender instability and shows how this can be performed through fashionable dress. I end by noting that Joyce, a male modernist often criticized for his reductive representations of women, is highly sensitive to the relationship between fashion and gender at this point in time.
Vision and knowledge
Authors: Mazierska Ewa
Published: March 2017

The article discusses It Can Pass Through the Wall in the context of New Romanian Cinema, arguing that its subject is a search for knowledge and the difficulty of finding it, which feeds the characters’ curiosity. It also suggests that the film can be regarded as a metaphor for the position of every film viewer.
Sound as performative space
Authors: Melvin Adam
Published: March 2017

This article discusses how the combination of circumambient sound and predominantly fixed camera position in It Can Pass Through the Wall achieves a similarly spatial and performative use of sound to that found in multi-channel electroacoustic concert performances. I consider to what extent space itself can ‘tell a story’.
The unseen and the unspeakable
Authors: Király Hajnal
Published: March 2017

In the context of Dutch seventeenth-century painting thematizing eavesdropping and the use of off-camera voice in classic cinema, this article explores the relationship between framing and voice-off, revealing its figurative potential in representing the taboo of death as a threshold that is inaccessible to perception and cognition.
The mobile middle: Indian skilled migrants in Singapore and the ‘middling’ space between migration categories
Authors: Baas Michiel
Published: March 2017

Studies of skilled migration tend to be strongly bifurcated in terms of their focus on either low- or highly-skilled migrants, and public debate generally also reflects this. However, since skills, education and income levels are frequently conflated, there are usually considerable differences in terms of how low or highly skilled migrants actually are. In addition, there has been little attention paid to strategies of mobility between various visa categories. This article focuses on what it conceptualizes as the ‘mobile middle’: skilled migrants who actively negotiate and test the flexibilities of a migration programme in order to be able to work and potentially stay on ‘permanently’ in a particular country. Drawing on ethnographic fieldwork among Indian (mid-level) skilled migrants in Singapore, the present study explores how we can (further) conceptualize migration categories, and the ways migrants engage with them with respect to inherent constraints on the one hand and ambitions for the future on the other. With its focus on Singapore, the article also highlights how the mobile middle, as a rapidly growing group of migrants, takes up an increasingly prominent place in discussions about new immigrants and population growth.