bluuebunny/crossref_metadata_2025 huggingface dataset:
The Intellectual Network of Shaykh Abdusshamad Al-Falimbani and His Contribution in Grounding Islam in Indonesian Archipelago at 18th Century AD
Authors: Imawan Dzulkifli Hadi
Published: August 2023

This paper aimed to discuss about the intellectual network of Shaykh Abdusshamad al-Falimbani and his contribution to the grounding of Islam in Indonesia during the 18th century. He was one of the great scholars who had an intellectual network in Indonesian archipelago and Arabian Peninsula. He played a big role in the dissemination of Islamic lecture in both countries. His impact was widely documented in the biographies of the Arabic figure (tarajim) and isnad. Therefore, this study attempted to trace his intellectual network and his contributions to the Islamic world, especially in Indonesia at 18th century. This study used a literature study on the biography of Shaykh Abdusshamad al-Falimbani, information was obtained from literature sources related to him and his work. The results of this study revealed that Shaykh Abdusshamad al-Falimbani had a lot of intellectual networks that connected the Indonesian and Arabian Peninsula’s scholars  and played a major role in grounding Islam in Indonesia. This was carried out through the caderization of his students and the publication of his writings, which brought by his students to Indonesia. His works encouraged Indonesian Muslims to adhere to the teachings of Ahlu al-Sunnah wa al-Jama'ah, hold on to syafi’i madzhab, and accept the sunni tasawwuf as the teachings of the Prophet.
Vinte anos da Lei n. 10.639/2003, a produção do ProfHistória e a formação continuada de professores(as)
Authors: Coelho Wilma de Nazaré Baía , Brito Nicelma Josenila Costa de , Cruz Felipe Alex Santiago
Published: August 2023

O artigo ora apresentado inspeciona a formação continuada de professores(as) por meio do Programa de Pós-Graduação stricto sensu ProfHistória, com o objetivo de mapear o avanço das produções do ProfHistória nesse decurso dos vinte anos da Lei n. 10.639/2003. Para cumprir esse escopo, procedemos o levantamento das dissertações produzidas no recorte temporal demarcado pelos vinte anos da promulgação da Lei, mediante o qual obtivemos 31 (trinta e uma) dissertações produzidas desde a conclusão da primeira turma de ingressantes no Programa, em 2016. Mobilizamos, nas reflexões tecidas neste artigo, as formulações de Francisco Imbernón (2010), Maria Amélia Franco (2016), Ivor Goodson (2003), Pierre Bourdieu (2012) e Roger Chartier (1990, 1991) sobre formação continuada de professores(as), prática pedagógica, currículo, dominação simbólica e campo, e representação, respectivamente. Os resultados informam o permanente diálogo presente no processo de formação continuada com a escola básica, mediante a produção das dissertações que conferem visibilidade à temática da ERER, pautadanas orientações da Lei n. 10.639/2003.
The use of instructional media in the excretory system: a study on the perspectives of teachers and eleventh grade students of senior high school
Authors: Dewi Safira Permata , Anggraini Lutfiah , Tibrani Masagus Muhammad
Published: August 2023

Selection of learning media can affect the learning process that takes place in class. In addition, teachers are required to have the ability to use instructional media. This study aims to find out the types of learning media and how teachers get the learning media used in excretion system material. This survey research involved class XI students of public and private high schools in Palembang City, Indonesia. Samples of students were taken using the Stratified Cluster Random Sampling technique based on Accreditation A (266), Accreditation B (80) and Accreditation C (25) (n = 371) from 11 high schools in Palembang City. The sample of teachers was taken from the schools that were sampled in this study (Accreditation A 10 teachers, Accreditation B 3 teachers and Accreditation C 1 teacher) (n=14). The instrument used in this study was a questionnaire sheet for students and teachers. Questionnaire sheets were developed by taking into account learning indicators. The results of the student questionnaire showed that students were more interested in audio-visual and visual media. The audio-visual media that students like is learning videos, while the visual media that is preferred is the use of real objects and artificial objects. Meanwhile, the learning media most often used by teachers are audio-visual media and visual media. Students give a positive response to the media used by the teacher, even though the teacher does not develop the learning media himself. The results of this study are expected to assist teachers in choosing suitable learning media for use in biology lessons on excretory system material.
The effect of android-based augmented reality lab coats on students with different academic abilities on understanding of skeletal system
Authors: Pamungkas Sekar Jati , Permadani Karunia Galih , Yuniarti Nur Nafisyah , Meganingrum Andari Rosiana
Published: August 2023

The understanding of students' concepts of SMP Negeri 1 Kandangan on the material of the skeletal system is still low. This study aims to determine the effect of applying Android-based Augmented Reality laboratory coats to students with different academic abilities on understanding the concept of skeletal system material for students of SMP Negeri 1 Kandangan. This research is a quasi-experiment or quasi-experiment with a pretest-posttest control group design. The population used in this study were all seventh-grade students of SMP Negeri 1 Kandangan. In contrast, the samples in this study were class VII A as the control class and class VII B as the experimental class, which would be treated as applying an Augmented Reality Android-based. The sample was determined using a purposive side technique. The ANCOVA test results show a significant difference in student's conceptual understanding of the skeletal system material between the control and the experimental, with a significance value or p of 0.006, which is <0.05. Meanwhile, the follow-up test results showed that the use of android-based Augmented Reality Laboratory Coat learning media significantly differed in understanding the concepts of seventh-grade students of SMP Negeri 1 Kandangan. So it can be concluded that the android-based Augmented Reality Laboratory Coat affects increasing the understanding of the concepts of students with different academic abilities at SMP Negeri 1 Kandangan as a learning medium on skeletal system material to provide a better visualization effect in observing bony structures in the passive motion system (bones).
Ethnoscience Ethnoscience study to convert kerinci community knowledge in the processing of kawa drinks
Authors: Haryanto Toni , Kencanawati Indah
Published: August 2023

The district's traditional drink, kawa drink, made from dried coffee leaves, is used by the Kerinci people. The primary purpose of this investigation is to use ethnoscientific research to turn common knowledge about the techniques used in processing kawa drinks into scientific knowledge. This study employs a qualitative, ethnoscientific phenomenological methodology that includes observation, which involves learning where to gather the coffee leaves that will be used to make kawa drinks  in the step one. The finding out how to turn coffee leaves into kawa drinks was the second step of the interview. The third step involves documenting several steps in the processing of coffee leaves into kawa drinks and the data must then be subjected to a descriptive qualitative analysis as the final step. The Miles-Huberman approach for data analysis includes data reduction, data presentation, conclusion-drawing, and verification. The study's results show that while the process of transforming kawa drinks into traditional drinks is a local tradition that has developed over the years, the tradition of drinking kawa has not changed since the transformation of local knowledge. The six steps make up the process of converting coffee leaves into kawa drinks: leaves collection, drying, smoke of kawa leaves, packaging, dissolving, and serving drinks. The tradition of making and consuming kawa drinks in Ujung Pasir Kerinci Village has the potential to serve as a source of community knowledge to convert of tradition into scientific science.
Information literacy profile of biology education students in different batch
Authors: Tauhidah Dian , Wijayanti Erna
Published: August 2023

Information literacy is one of the basic skills that students must have in today's digital era. This research was conducted to analyze the information literacy profile of students in different batch years. This quantitative study compared three groups of data based on the student year. The research population was all biology education students at UIN Walisongo Semarang. The research sample was determined using a stratified random sampling technique to obtain 94 students divided into three grades. The data were obtained using the information literacy test instrument and analyzed using the ANOVA test. Information literacy indicators consist of identifying information, accessing information, evaluating information, using information effectively, and understanding the ethics of using information. The study results show that students in all classes have information literacy skills in the sufficient category, but significant differences exist between batch years. The lowest information literacy ability was in first-year students, followed by second-year students, and the highest in third-year students. The study results indicate the need to increase students’ information literacy.
Do Digital Technologies Support Entrepreneurship Growth? Evidence from Indonesian Muslim Women in Depok City
Authors: Hamadou Issa
Published: August 2023

The main objective of this paper is to assess the impact of digital technologies on the entrepreneurial output of Muslim women in Indonesia. Using a questionnaire, we collected data from Muslim women entrepreneurs involved in digital entrepreneurship in Depok city. We applied multiple linear regression to analyze the data. We found that the use of e-commerce platforms and internet services affects positively the entrepreneurship growth of Muslim women in Indonesia. However, online payments have been found non-significant because of awareness of risk and security towards online payment system. One of the limitations of this research is the size of the sample. Obtaining data from Muslim women entrepreneurs was very difficult. Again, the case under study is limited to one country. Therefore, it is recommended for future research to use a large sample size and include more countries. Indonesian government should implement tax reduction policies in order to improve the growing sector of Muslim women entrepreneurs, which can help them to become empowered in society.
Implementasi Sifat STAF (Siddiq, Tabligh, Amanah, Fathanah) Pada Pemasaran Madu Afifah Honeybee
Authors: Ivtin Kurniawati  , Said Abadi
Published: August 2023

Introduction: This research discusses applying the characteristics of STAF (Siddiq, tabligh, Amanah, and fathanah) in Afifah Honeybee marketing to strengthen consumer decisions in buying Afifah Honeybee products. The nature of STAFF is viral among scholars but still needs to be widely applied in the business world; for this reason, this study intends to examine the application and impact of the nature of STAF in the business world. Research Methods: The research will produce qualitative descriptive data by using qualitative research methods and field research. Interview, observation, documentation techniques, data models, and drawing conclusions collected data. Results: The study results show that Afifah Honeybee's marketers have tried to apply the characteristics of STAF even though it could be more optimal. Conclusion: This application significantly positively impacts consumers' decisions to buy Afifah Honeybee's products.
Analisis Peran Organisasi Dalam Kegiatan Kelompok Tani “Bajang Peduli” Desa Bungkuk Kecamatan Parang Kabupaten Magetan Untuk Peningkatan Produktivitas
Authors: Zidni Ardiana Firdaus  , Iza Hanifuddin
Published: August 2023

This research is motivated by a form of concern for the problems faced by farmers, especially in the "Bajang Peduli" farmer group in Bungkuk Village, Parang District, Magetan Regency with several problems, namely poverty that still exists among farmers, less than optimal productivity increase, distribution of subsidized fertilizers which is still not optimal for members of farmer groups, the use of infrastructure facilities provided by the government is still lacking due to human resource factors. The primary purpose of this study was to analyze the organization's role in the activities of the "Bajang Peduli" farmer group to increase farmer productivity in Bungkuk Village, Parang District, Magetan Regency. The type of research used is the type of field research. The research was conducted on a farmer group, "Bajang Peduli," in Bungkuk Village, Parang District, Magetan Regency, with data collection techniques using interviews, observation, and documentation. The results of this study indicate that (1) the organization's role in this farmer group's activities still needs to be maximized. (2) The importance of the role of organizations in community activities that have joined the "Bajang Peduli" farmer group is still not fully understood. (3) The impact of the organization's organization's role in the activities of the "Bajang Peduli" farmer group is still not maximally achieved because there are factors that cause and affect farmers' production results. This is evidenced by increasing farmer productivity in Bungkuk Village, Parang District, Magetan Regency.
Project approach to the development of mountain tourism in the North Caucasus
Authors:   Perm State National Research University, OBORIN Matvey
Published: August 2023

Introduction. Mountainous territories in Russia are an important element of the development potential, especially this direction is relevant in the field of tourist and recreational services. Many subjects of the Russian Federation have a certain area that falls on mountainous areas. Domestic and international practice has convincingly shown that they can contribute to the growth of socio-economic indicators of the region due to successful integration into the economic system. At the same time, there are a number of objective restrictions on the development of active types of tourism associated with increased risks of some of them, such as the North Caucasus. The article discusses the main types of active recreation in the highlands, problems and prospects of the tourism industry development in the North Caucasus Federal District. The conclusion is made about the sustainable development of this type of tourism in the North Caucasus. The purpose of the study is to analyze the problems and conditions of effective development of the mountainous territories of the North Caucasus. Materials and methods. The information base of the research was the scientific and methodological developments of domestic authors on the problem under study, national and regional concepts, strategies and programs for the development of tourism in the Russian Federation until 2035. The research methodology is the scientific analysis and systematization of the data obtained. In the course of the research, general scientific methods and approaches were applied: abstraction, analysis and synthesis, logical method; systematic approach. Results and discussion. According to most experts, the effective and sustainable development of the tourism industry in the mountainous territories of the North Caucasus Federal District requires, first of all, the formation of appropriate legal acts concerning mountainous territories at the federal level. Effective development measures should be developed for the mountainous territories of the North Caucasus to attract tourists and form a positive image of the region as a ski resort. Conclusion. The measures taken contribute to the flow of large investments into the region, which, in turn, will help the development of a highly developed tourist and recreational complex in the North Caucasus.
Mathematical and computer modeling of gantry crane load-beam system oscillation
Authors:   Institute of Energy and Mechanical Engineering, YELEMESSOV Kasym , ISAMETOVA Madina ,   Institute of Energy and Mechanical Engineering, SAYDINBAYEVA Nazym ,   Abylkas Saginov Karaganda Technical University, KUKARTSEV Vladislav ,   Siberian Federal University
Published: August 2023

Introduction. Gantry grappling cranes are the main equipment for cargo transportation in the technological processes of mining and enrichment of rocks. During the operation of the crane, undesirable effects such as the rocking of the payload occur, which in turn affects the dynamic state of the crane beam. Materials and methods. To solve this problem, methods of mathematical and computer modeling of a system with two degrees of freedom were used. To identify the influence of different combinations of the combination of payload mass and cable length on oscillation frequencies, a computational experiment was carried out and the response surface of the oscillation frequency function was constructed. The natural oscillation frequencies of the beam were determined by the finite element method in the NASTRAN program. Results. The results of mathematical modeling were graphs of changes in the angle of deviation of the cable from the vertical and the movement of the trolley, the response surface of the frequency of oscillation of the payload from the length of the cable and the weight of the cargo. Discussion. A comparison of the simulation results of cargo vibrations and crane beam vibrations showed the proximity of the values of the frequencies of the payload vibrations and the gantry crane design, which justifies the need for further analysis of the frequency response of the crane beam to the disturbance of the payload vibration force. Conclusion. The frequency of vibrations of the load significantly affects the static and vibration strength of the crane beam of the gantry crane Resume. The research results can be useful in the development of technical solutions for the engineering implementation of promising gantry crane designs.
Contribution of a single flower visit of Xylocopa olivacea (Hymenoptera: Apidae) on fruit and seed production of Roselle (Hibiscus sabdariffa L.) (Malvaceae) at Meskine (Maroua, Cameroon)
Authors: Yougouda Aminou , Topé Sidonie Fameni , Kengni Beaudelaine Stephanie , Fohouo Fernand-Nestor Tchuenguem
Published: August 2023

There a wide diversity of values linked to insect pollinators and pollination beyond agriculture and food production. To evaluate the impact of a single flower visit of Xylocopa olivacea on fruit and seed yields of Hibiscus sabdariffa, its foraging and pollinating activities were studied at Meskine (Maroua, Cameroon), in June 2018 and 2019. The experiments were carried out on 540 flowers divided into four treatments: protected flowers, bagged flowers, flowers protected and then exclusively exposed to X. olivacea and unbagged flowers, then reprotected without any visit of insect or some other life form visit to exclude the effect of hands manipulation. The bee’s daily rhythm of activity, its foraging behaviour and its pollination efficiency were evaluated. X. olivacea foraged on H. sabdariffa flowers throughout the plant’s blooming period. Among the 22 insect species recorded on H. sabdariffa flowers, X. olivacea was the most frequent insect with 40.89% of the 1670 recorded visits, and it intensely collected nectar and pollen. The fruiting rate of unprotected flowers was significantly higher than that of protected flowers (χ2 = 20.98; df = 3; P < 0.001). Through its pollination efficiency, X. olivacea provoked a significant increase in the fruiting rate by 49.98%, the number of seeds per fruit by 5.40%, and the percentage of mature seeds by 13.99%. Therefore, conservation of X. olivacea nests close to H. sabdariffa fields is recommended to improve fruit and seed production in this region.
A Counselling Intervention for Individual Strategies to Prevent Complications and Strengthen Resources during Pregnancy in the Gynaecological Care (AOK-Family+): Study Protocol for a Cluster-Randomised Controlled Trial
Authors: Krämer Mareike , Wohlhüter Laura , Hermeling Lina , Koetsenruijter Jan , Kamradt Martina , Wensing Michel , Bombana Manuela
Published: August 2023

Background
Lifestyle-related risk factors can increase complications during pregnancy and negatively impact the health of a mother and her child. Knowledge about these compliances among many pregnant women and women of childbearing age is lacking. In the study AOK-Family+, we propose the evaluation of a newly developed counselling intervention. The intervention aims to raise awareness and to provide relevant information about the impact of lifestyle-related risk factors during pregnancy. The aim of the proposed study is to evaluate the effect of this counselling intervention on women’s knowledge of lifestyle-related risk factors during pregnancy and the concomitant healthy behaviours.
Methods
A cluster-randomised trial with three arms in Baden-Wuerttemberg, Germany, is proposed. Pregnant women and women of childbearing age will be allocated to one of three groups: online intervention, on-site intervention, or a waiting-list control. Trained counsellors from AOK Baden-Wuerttemberg, a German statutory health insurer, will conduct the counselling sessions. Data collection is conducted throughout validated questionnaires administered at three intervals: before counselling (t0), directly after counselling (t1), and at a six-week follow-up (t2). The primary outcomes will be health knowledge and healthy behaviours relating to LRFFs during pregnancy. A process evaluation will examine the processes, used resources, and future implementations through additional quantitative questions and qualitative interviews and focus groups.
Discussion
Based on this study, an implementation strategy for future conduction of lifestyle consultation during pregnancy could be developed with the aim of reducing pre- and post-mortem mobility and mortality.
Trial registration
This study is registered in the German Clinical Trials Register, https://www.bfarm.de/DE/Das-BfArM/Aufgaben/Deutsches-Register-Klinischer-Studien/_node.html, as DRKS00027804, 2022/01/12.
FEDDBN-IDS: Federated Deep Belief Network-based Wireless Network Intrusion Detection System
Authors: M Nivaashini , E Suganya , S Sountharrajan , M Prabu , Bavirisetti Durga Prasad
Published: August 2023

Past two decades, Wi-Fi innovation has developed so generally that most contemporary gadgets are compact and use Wi-Fi to access the web. Because no physical boundary separates a wireless network from a wired network, Wi-Fi network security is seriously questioned, and current security measures are helpless to an extensive variety of attacks. The objective of this research was to evaluate a novel approach called federated learning as a potential solution to address privacy concerns and high costs associated with data collection in the field of recognizing network attacks. The study introduces FEDDBN-IDS, a ground-breaking intrusion detection system (IDS) that utilizes deep belief networks (DBNs) within a federated deep learning (FDL) framework to detect and identify cyber threats specifically in Wi-Fi networks. A DBN with stacked restricted Boltzmann machines (RBM) was trained on each device to learn the low-dimensional features from unlabelled private and local data. A central server later combines these models into a global model (FL) using federated learning. Subsequently, the central server adds fully connected SoftMax layers to the overall model to create a supervised neural network and train the model using freely available labeled AWID datasets. The results obtained from our experiments on the AWID intrusion detection dataset indicate that our federated strategy achieves a high level of classification accuracy, ranging from 88% to 98%.
Exploring the Diversity and Abundance of Necrophagous Flies in Tabriz City, Northwest of Iran: Implications for Medical and Health Importance
Authors: Abbasi Madineh , Azarmi Sahar , Dehghan Omid , Doosti Sara , Hokmabad Behrooz Naghili , Bazmani Ahad , Farmani Mostafa , Akbarzadeh Kamran
Published: August 2023

Background: Flies are of medical importance and cause problems by transmitting mechanically various pathogens to human and animals and myiasis. This study was performed to determine the diversity and abundance of medically important flies in Tabriz city, Northwest of Iran.
Methods: Adult flies and their larvae trapping was conducted on a monthly basis from July to October 2021. Then, the trapped flies were identified morphologically using valid identification keys. Simpson index, Shannon index, Jackknife Procedure, Margalef index, Menhinick index, Camargo, Modified Nee, and Smith and Wilson indexes were calculated to determine species diversity and species richness and species evenness as well as species biodiversity of flies. Also, the rare or dominant species was estimated by Rarity richness index.
Results: In this study, totally 17 species flies including Musca domestica, Muscina stabulans, Phaonia spp., Hydrotaea spp., Musca autumnalis, Lucilia sericata, Chrysomya albiceps, Calliphora vicina, Sarcophaga africa, Sarcophaga variegata, Sarcophaga argyrostoma, Sarcophaga aegyptica, Sarcophaga sp., Sarcophaga lehmanni, Sarcophaga (Liosarcophaga) spp., Fannia sp., and Anthomyia sp. from five families (Muscidae, Calliphoridae, Sarcophagidae, Fanniidae, and Anthomyiidae) were identified. According to the bootstrapping method, Simpson index and Shannon index were 0.792 and 2.638, respectively and the number of common species was estimated to be 6.22 at the 95% confidence level. The highest species diversity was related to Sarcophagidae family and the lowest of that was related to Muscidae family by Shannon index. Musca autumnalisand M. domestica species were recognized as the rare species and the dominant species, respectively.
Conclusions: The highest number of fly species (14) were caught in August and September, and the lowest number of species (9) in October. Due to the medical and health importance of flies, it is recommended to take measures to control population of these insects.
Impact of a virtual reality-based simulation training for shoulder dystocia on human and technical skills among caregivers: A randomized-controlled trial
Authors: Falcone Veronica , CATIC Anja , HEINZL Florian , STEINBAUER Philipp , WAGNER Michael , ECKEL Fanny , DORITTKE Tim , ROESSLER Bernhard , FARR Alex
Published: August 2023

Background:This study analyzed the adherence to the modified Advanced Life Support in Obstetrics (ALSO) algorithm (HELP-RER) for handling shoulder dystocia (SD)using a virtual reality (VR) training modality. Secondary outcomes were improvements in the post-training diagnosis-to-delivery time, human skills factors (HuFSHI), and perceived task-load index (TLX).
Methods:Prospective, case-control, single-blind, 1:1 randomized crossover study. Participants were shown a 360-degree VR video of SD management. The control group was briefed theoretically. Both groups underwent HuFSHI and HELP-RER score assessments at baseline and after the manikin-based training. The TLX questionnaire was then administered. After a washout phase of 12 weeks, we performed a crossover, and groups were switched.
Results:There were similar outcomes between groups during the first training session. However, after crossover, the control group yielded significantly higher HELP-RER scores [7 vs. 6.5; p=0.01)], with lower diagnosis-to-delivery-time [85.5 vs. 99 seconds; (p=0.02)], and TLX scores [57 vs. 68; (p=0.04)]. In the multivariable linear regression analysis, VR training was independently associated with improved HELP-RER scores (p=0.003). The HuFSHI scores were comparable between groups.
Discussion:Our data demonstrated the feasibility of a VR simulation training of SD management for caregivers. Considering the drawbacks of common high-fidelity trainings, VR-based simulations offer new perspectives.
Ancient Hydrological Changes of the Downstream Yuan River Based on Historic Buildings
Authors: zheng dan dan , Gui yuhui , Yang nai , Bing he
Published: August 2023

This paper aims to reconstruct the hydrological changes in the downstream Yuan River after the Tang Dynasty using historic building sites such as water temples, stone markers, etc. It is challenging to restore the ancient hydrological environment according to current satellite image technology, historic topographical maps, geographic information system data, and documentary records. However, historic building sites have unique ancient cultural and environmental value. This paper proposes a method of superimposing ancient ruins to confirm the ancient shoreline and ancient water level of the lower Yuan River in antiquity, and analyzes the value of the ancient river shoreline and ancient water level through historic buildings. It is suggested that the ancient shoreline may be evidenced by the Zhenlongge Water God Temple and ancient water level by Stone Markers.
Depression And Anxiety In Parents Of Children With Neurodevelopmental Disorders In Saudi Arabia
Authors: Alsaad Ali J. , Khamees Mujtaba M. Al , Alsaleh Majd A. , Alkadi Abdulelah N. , Alshairdah Aeshah S. , Alessa Zahra'a A.
Published: August 2023

Background: Raising a child with Neurodevelopmental disorders (NDDs) can be difficult because it affects the sociality of the parents and their relationships and requires parents to have another set of skills to deal with their child. Hence, the risk of depression and anxiety will increase.
Methodology: This study is a prospective, qualitative, cross-sectional, anonymous questionnaire-based study, in which four hundred and sixteen parents of children with (NDDs) in Saudi Arabia participated. The sample size was determined using the Richard Geiger equation with a margin error of 5%, a confidence level of 95%, and 50% for response distribution. The screening was done using a validated Arabic version of Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7) which disturbed into Saudi neurodevelopmental disorders related associations and clinics, and psychiatric clinics. The data were collected, reviewed, and then fed to Statistical Package for Social Sciences version 21 (SPSS: An IBM Company).
Results: Our study demonstrated that (85.1%) of parents of children with (NDDs) have depression and (85.5%) have anxiety, with no significant difference between mothers and fathers in rates of depression and anxiety. Furthermore, no significant difference was measured between the type of (NDDs) and rates of depression and anxiety in parents.
Conclusion: Children with (NDDs) affect their parent’s mental health in terms of increasing rates of depression and anxiety. The increase is not correlated with specific etiology. To combat this phenomenon, increasing efforts must be placed to combat this issue.
Influence of NUDT15 Genotyping on Dose Intensity of Thiopurine Administration and Long-Term Clinical Outcomes (Hospitalization and Surgery)
Authors: Tsunoda Shotaro , Kojima Yuichiro , Hirotsu Yosuke , Amano Hiroyuki , Miura Yuko , Ashizawa Hiroshi , Ohyama Hiroshi , Hosoda Kenji , Suzuki Yoji , Mochizuki Hitoshi , Maeda Shin , Omata Masao
Published: August 2023

Background
Thiopurines are one of the major drugs for treatment of inflammatory bowel disease. It is well known that SNPs in TPMT are the main cause of leucopenia and hair loss in European descent. In Asian individuals, the SNP p.Arg139Cys in exon 3 of NUDT15 is associated with leucopenia and hair loss. Previously, we demonstrated that thiopurine-induced leucopenia is related not only to exon 3 but also exon 1 SNPs in a cohort followed for a short term. The aim of this study was to evaluate the long-term effects of NUDT15 on clinical outcomes.
Methods
Patients (ulcerative colitis130 cases, Crohn’s disease 55 cases) were divided into mutation and wild-type NUDT15 groups, and the daily dosage of thiopurines and the effect of mutation on hospitalization and surgery were retrospectively investigated over a long period of up to 10 years (median, 7.8 years).
Results
Regarding TPMT SNPs, p. Pro80Ala, p. Thy154Ala and p. Tyr240Cys were not detected, and all genes were wild-type. Compared to the NUDT15 mutation group (n = 48), the daily thiopurine dosage was increased in the wild-type group (n = 137) (p = 0.024). The time to dose reduction and discontinuation of thiopurines was significantly shorter in the NUDT15 mutation group (p < 0.001, p = 0.039). The NUDT15 mutation group tended to have more hospitalizations (p = 0.067), and surgeries were significantly more frequent (p = 0.028). In ulcerative colitis patients, thiopurine discontinuation was associated with hospitalization and surgery (p = 0.003, HR 2.87, 95% CI 1.44–5.71, p = 0.036, HR 5.45, 95% CI 1.12–26.5). In Crohn's disease patients, the presence of SNPs was associated with hospitalization (p = 0.019, HR 3.68, 95% CI 1.24–10.97) and surgery (p = 0.036, HR 6.81, 95% CI 1.14–40.86).
Conclusions
The presence of the NUDT15 mutation affects maintenance of thiopurine dosage in the long term. In ulcerative colitis, it is important to continue thiopurines with fine-tuning of the dosage to avoid hospitalization and surgery. In Crohn's disease, a direct association between NUDT15 SNPs and hospitalization and surgery was found.
Thermal indices for human biometeorology based on Python
Authors: Chen Yung-Chang
Published: August 2023

Thermal indices, such as predicted mean vote, outdoor standard temperature, physio- logically equivalent temperature, universal thermal climate index, are essential for eval- uation of thermal perception, climate sensitive building or urban design, and tourisms climate in decades. Behind these thermal indices are complicated numeric models. Therefore, RayMan has been developed as an application software for calculation of thermal indices based on Delphi program language on windows 7 operation system platform. Currently, RayMan is not able to be under maintenance and further devel- oped. Thus, the report depicts an innovative Python library - biometeo - including an innovative thermal index - modified physiologically equivalent temperature - as an in- herited program to calculate thermal indices and human biometeorological variables.
Effect of the telemedicine-supported multicomponent exercise therapy in patients with knee osteoarthritis: study protocol for a randomized controlled trial
Authors: Feng Yuan , Wu Yan , Liu Huizhen , Bao Tianjie , Wang Chongyang , Wang Zezhang , Huang Jielei , Jiang Yiwei , Zhu Siyi , He Chengqi
Published: August 2023

Introduction: The rising prevalence of knee osteoarthritis is placing a considerable strain on the global healthcare system. To address this issue, telemedicine-supported multicomponent exercise therapyhas emerged as a promising approach. This therapy combines exercise, patient education, and health coaching to empower knee osteoarthritis patients to manage their condition from the comfort of their homes. Nevertheless, there are some existing limitations in the current research on this approach, including challenges related to patient compliance and the absence of objective evaluation methods.
Methods and analysis: Patients diagnosed with knee osteoarthritis, who have not undergone knee surgery in the past year, will be recruited for a randomized controlled trial. The trial will include an intervention group and a control group. The intervention group will receive an mHealth app-based multicomponent exercise therapy, consisting of exercise therapy, patient education, and health coaching. Meanwhile, the control group will receive usual care, involving drug therapy and patient education. The primary outcome of the trial will be the measurement of pain intensity, assessed using a visual analogue scale at baseline and at 4, 8, and 12 weeks of the intervention. To analyze the data, a two-factor, four-level repeated measures ANOVA will be used if the assumptions of homogeneity of variance and sphericity are met. If not, a mixed effects model will be employed.
Discussion: The aim of the study was to evaluate the effectiveness of multicomponent exercise therapy aimed at enhancing pain self-management for knee osteoarthritis patients in the comfort of their own homes. The intervention incorporated wearable devices equipped with advanced deep learning systems to monitor patients' adherence to the prescribed at-home exercise regimen, as well as to track changes in outcomes before and after the exercise sessions. The findings from this trial have the potential to enhance both the accessibility and quality of care provided to knee osteoarthritis patients, offering valuable insights for future improvements in their treatment and management.
Trial registration: Chinese Clinical Trials Registry, ChiCTR2300073688. Registered 19 July 2023, https://www.chictr.org.cn/bin/project/edit?pid=199707.
Airway management effect of the new video laryngeal mask airway SaCoVLMTM in lateral laparoscopic urological surgery: A single center randomized controlled trial
Authors: Sun Yongtao , Zhang Min , Gao Xiaojun , Gao Zhongquan , Zou Ting , Guo Yongle , Liu Mengjie , Chen Lina , Zhang Xiaoning , Liu Yang , Feng Hai , Wang Yuelan
Published: August 2023

There are few pertinent researchs about the application of laryngeal mask airway (LMA) in lateral decubitus surgery. The aims of our study were to evaluate the effects of lateral position and pneumoperitoneum on oropharyngeal leak pressure (OLP) and ventilation efficiency for the LMA SaCoVLMTM. Patients undergoing elective retroperitoneal laparoscopic urological surgery were randomized 1:1 to the SupremeTM group or SaCoVLMTM group. The primary outcome was the OLP with LMA insertion. Secondary outcomes were the first-attempt success rate, insertion time, adjustment times, gastric tube success rate, LMA alignment accuracy, LMA removal time, regurgitation or aspiration, LMA blood staining, and incidence of adverse events 24 hours postoperatively. We recruited 70 patients to complete the study. Regardless of lateral position and pneumoperitoneum, OLP was higher in the SaCoVLMTM group (n = 35) than in the SupremeTM group (n = 35), with a median difference of 4-7 cmH2O. The first-attempt success rate of the SaCoVLMTM group was higher than that of the SupremeTM group (91.4% vs. 77.1%, risk ratio (RR): 1.19; 95% CI 0.96 to 1.46, P = 0.188). In the lateral position and pneumoperitoneum, although the new video LMA SaCoVLMTM has a higher OLP than LMA SupremeTM, both devices provide sufficient ventilation efficiency.
The distributivity of extended semi-t-operators over extended S-uninorms on fuzzy truth values
Authors: Yang Bin , Li Wei , Liu Yuanhao , Xu Jing
Published: August 2023

Inspired by the thought of distributivity between semi-t-operator and S-uninorm, this paper primarily explores the distributivity between extended semi-t-operator and extended S-uninorm on fuzzy truth value.Firstly, Zadeh-extended semi-t-operator and S-uninorm are proposed on fuzzy truth value and some results of extended semi-operator are studied under special fuzzy truth values.Then, it concentrates on the sufficient condition about left and right distributivity of extended semi-t-operator over extended S-uninorm under the condition that semi-t-operator is left and right distributive over S-uninorm, respectively.Finally, when parameters satisfy different cases, sufficient conditions for the distributivity between extended semi-t-operator and extended S-uninorm are given under the condition that semi-t-operator satisfies distributivity or conditional distributivity over S-uninorm.
Combined antifungal activity of cyclic lipopeptides and cinnamon extract: From in vitro experiments to the control of Fusarium wilt of banana
Authors: Ramírez-Mejía Julieta M. , Aguilera-Galvez Carolina , Kema Gert H.J. , Valencia-Riascos Luisa M. , Zapata-Henao Sebastian , Gómez Luis A. , Villegas-Escobar Valeska
Published: August 2023

Fusarium wilt of banana (FWB) caused by soil-borne Fusarium oxysporum f.sp. cubense (Foc), is a widely distributed disease that generates devastating losses in banana. The most aggressive Foc tropical race 4 (TR4), attacks Cavendish clones and a diverse range of other banana varieties. Management practices to suppress Foc are emerging, however they are challenging. Therefore, enhancing biological control activities could potentiate FWD control practices. Here we determine the antifungal synergistic effect of plant-based cinnamon (Cinnamomum zeylanicum) extract and Bacillus tequilensis EA-CB0015 cyclic lipopeptides against Fusarium sp. strains in vitro and in banana plants in greenhouse. We found, through a bioprospecting assay of 17 plant-based natural extracts, that cinnamon was highly active against Foc isolate IB (race 1). Furthermore, cinnamon and cyclic lipopeptides inhibited different Fusarium spp. strains belonging to race 1 and TR4, and their combination increased 1.4-fold the effect of the single extracts in vitro. Our results demonstrate that soil concentration of F. odoratissimum TR4-II5 was reduced by 78.5% with the combination treatment in a soil microcosm system. Although, while the combination reduced external FWB symptoms, only cinnamon extract had a significant impact on internal symptoms in plants. Taken together, the biological control effect of cyclic lipopeptides with cinnamon extract on Fusarium spp. supports their function towards increasing soil health and reducing disease intensity and suggests that the combination enhances the effect of the single extracts.
Implementation study of virtual goals of care consultation for advanced frailty: Lessons learned from the Pandemic
Authors: Shetty Nabha , Miller Ashley P. , Hill Tanya , Buckler Melissa , Mallery Laurie , Krueger-Naug Anne Marie , von Maltzahn Maia , Tinning Amanda , Moorhouse Paige
Published: August 2023

Background
Long-term care (LTC) residents disproportionately experienced critical illness and death in the setting of COVID-19. In response, a virtual specialist consultation service known as the "Med-LTC program" was developed to support residents and their families with advance care planning to establish acceptable levels of health care intervention. The program significantly improved goals of care to align with resident frailty and expected outcomes in the event of an acute health crisis. A post-implementation inquiry explored the factors that influenced the program success to inform ongoing collaboration between acute care and LTC sectors in the delivery of frailty-informed care.
Methods
The factors that impacted program effectiveness and implementation outcomes were systematically explored using the Consolidated Framework for Implementation Research (CFIR). Structured interviews (n = 20) were conducted with LTC leadership, LTC healthcare staff, and members of the program. Qualitative data were extracted from the transcripts and coded to the domains and constructs of the CFIR.
Results
The CFIR constructs of inner setting, intervention characteristics, and individual characteristics were most strongly represented, with emphasis on tension for change, relative priority, relative advantage, and other personal attributes (shared team vision grounded in pre-existing social bonds) featuring prominently. Challenges in terms of complexity, cost, and relative priority all contributed to the ultimate lack of sustainability of the virtual program in the post-acute phase of the COVID-19 pandemic.
Conclusions
Application of the CFIR identified key barriers to and enablers of program success and providing important insights into factors supporting the development of more sustainable future iterations of virtual specialist consultation to establish goals of care in LTC.
The Triad of Physiological Challenges: Investigating the Intersection of Sarcopenia, Malnutrition, and Malnutrition-Sarcopenia Syndrome in COPD Patients - A Cross-Sectional Study
Authors: M Yogesh , Patel Jenish , Makwana Naresh , Mody Mansi
Published: August 2023

BACKGROUND
One of the most prevalent respiratory disorders in modern society is chronic obstructive pulmonary disease (COPD). Frequent comorbidities in COPD patients are abnormal nutritional status and body composition variations. Malnutrition-sarcopenia syndrome, which occurs when the two conditions – malnutrition and sarcopenia – coexist, raises the risk of death more than either condition alone. The current study sought to determine the prevalence of malnutrition, sarcopenia, and malnutrition-sarcopenia syndrome in COPD patients as well as the association between these diseases and the severity of COPD.
METHODS
The study was a cross-sectional study conducted on hospitalized COPD patients. The sample size of the study was calculated to be 160. A self-structured questionnaire was used to collect the data, containing sociodemographic characteristics, clinical profiles, anthropometric assessment, and bioimpedance indices. Hand grip was measured by a Hand Dynamometer. Assessment of the risk of malnutrition was performed using the Mini Nutritional Assessment-Short Form questionnaire and was confirmed by GLIM criteria. The COPD assessment test (CAT) tool determined the severity of the condition. For the data analysis, comparisons were made using Student’s t test and Mann–Whitney test in bivariate analysis. Multivariate logistic regression analyses were performed considering the outcomes of COPD patients by CAT scores, prolonged length of stay, and hospital readmission six months after discharge.
RESULTS
The mean age of the participants was 48±5 years. Approximately 61.9% were found to be sarcopenic. Approximately 45.6% of study subjects had malnutrition. Malnutrition sarcopenia syndrome was diagnosed in 38.1% of patients. The study analysis revealed that COPD patients with malnutrition-sarcopenia syndrome had more than twice the odds of prolonged hospital stay, re-admission within 6 months, and higher CAT scores.
CONCLUSION
The study revealed a high prevalence of sarcopenia, malnutrition, and malnutrition sarcopenia syndrome in patients with COPD. These conditions were found to be statistically significant with prolonged length of stay, re-admission within 6 months, and CAT scores. The findings highlight the importance of addressing these conditions as part of the management of the patients.
LINC01638 Sustains Human Mesenchymal Stem Cell Self-Renewal and Competency for Osteogenic Cell Fate
Authors: Gordon Jonathan , Tye Coralee E. , Banerjee Bodhisatwa , Ghule Prachi N. , Wijnen Andre J. , Kabala Fleur S. , Page Natalie A. , Falcone Michelle M. , Stein Janet L. , Stein Gary S. , Lian Jane B.
Published: August 2023

The skeleton forms from multipotent human mesenchymal stem cells (hMSCs) competent to commit to specific lineages. Long noncoding RNAs (lncRNAs) have been identified as key epigenetic regulators of tissue development. However, regulation of osteogenesis by lncRNAs as mediators of commitment to the bone phenotype is largely unexplored. We focused on LINC01638, which is highly expressed in hMSCs and has been studied in cancers, but not in regulating osteogenesis. We demonstrated that LINC01638 promotes initiation of the osteoblast phenotype. Our findings reveal that LINC01638 is present at low levels during the induction of osteoblast differentiation. CRISPRi knockdown of LINC01638 in MSCs prevents osteogenesis and alkaline phosphatase expression, inhibiting osteoblast differentiation. This resulted in decreased MSC cell growth rate, accompanied by double–strand breaks, DNA damage, and cell senescence. Transcriptome profiling of control and LINC01638-depleted hMSCs identified > 2,000 differentially expressed mRNAs related to cell cycle, cell division, spindle formation, DNA repair, and osteogenesis. Using ChIRP-qPCR, molecular mechanisms of chromatin interactions revealed the LINC01638 locus (Chr 22) includes many lncRNAs and bone-related genes. These novel findings identify the obligatory role for LINC01638 to sustain MSC pluripotency regulating osteoblast commitment and growth, as well as for physiological remodeling of bone tissue.