bluuebunny/crossref_metadata_2025 huggingface dataset:
Addressing adolescent anaemia in vulnerable urban Indian communities: A qualitative exploration
Authors: Ajgaonkar Vinita , Shaikh Nikhat , Shyam Rama , Karandikar Neeta , Patni Pallavi , Rajan Sheetal , Jayaraman Anuja
Published: December 2020

Objective:

Anaemia is a health problem for adolescents in India. This paper examines the nuanced transformations triggered by a multi-pronged, community-based anaemia intervention with adolescents and their families, seeking meaningful insights for future nutrition and anaemia programmes.

Design:

Qualitative study rooted in critical theory.

Setting:

Three slum communities – Dharavi and Kandivali (in Mumbai) and Kalwa (in Thane) in Maharashtra, India.

Methods:

Data were collected through focus-group discussions and in-depth interviews with young people, parents and other stakeholders. Content analysis of drawings of a nutritious food plate by participants supplemented discussion and interview data. Thematic analysis was undertaken manually using a grounded theory approach.

Findings:

Nutrition education with adolescents and parents led to reduced junk food consumption although reinforcement of the information provided was necessary to sustain the change. Parental support was a crucial factor in ensuring anaemia treatment compliance but was affected by a lack of awareness regarding the consequences of anaemia and the nutritional requirements of anaemic adolescents. Other factors, including the pampering of boys, the neglect of girls and the heavy workload of mothers influenced treatment compliance. Awareness and agency among adolescents contributed to a supportive environment in terms of raised consciousness and better sanitation within families and the community.

Conclusion:

Findings highlight the need for a holistic approach to address anaemia among young people. While nutrition and health education are important to address treatment noncompliance, this approach should also focus on factors such as socioeconomic status, gender equity, health prioritisation, family involvement and engaging young people as agents of change to promote an enabling environment.
Why Not Bargain? The Domestic Politics of Utilizing the World Trade Organization’s Dispute Settlement Mechanism
Authors: Lim Sijeong , Lee Hyo Won
Published: December 2020

The World Trade Organization’s dispute settlement mechanism is based on either bilateral bargaining or third-party rulings by a panel or the Appellate Body. When do countries utilize the multilateral procedure, and under what conditions do they opt for a bilateral agreement? Departing from previous studies emphasizing the role of the complainant in shaping the course of the dispute settlement mechanism, this article offers an explanation based on the strategic choices of respondents. This study suggests that the domestic political interests of respondent governments determine the use of the dispute settlement mechanism’s multilateral track. We argue that respondent governments choose the multilateral track to seek political cover for domestically unpopular concessions to a complainant. Such cover is required when (1) the dispute at stake has high public salience and (2) the respondent faces an upcoming election. Our hypotheses are tested using World Trade Organization’s dispute cases from 1995 to 2017.
Validation of Malayalam Version of Everyday Abilities Scale for India
Authors: Indu Pankajakshan Vijayanthi , Beegum Muthubeevi Saboora , KA Kumar  , Sarma Prabhakaran Sankara , Vidhukumar Karunakaran
Published: December 2020

Background:

Cognitive impairment is usually associated with impairment in everyday activities. Scales to assess activities of daily living, like the Everyday Abilities Scale for India (EASI), have been employed as screening tools for dementia or major neurocognitive disorder. EASI had not been validated in Malayalam. This study’s objective was to validate the Malayalam version of EASI (M-EASI) in those aged ≥60 years.

Methods:

In a study undertaken in a tertiary care center, those aged ≥60 years attending psychiatry, neurology, or geriatric clinic of general medicine departments were evaluated using M-EASI and the Malayalam version of Addenbrooke’s Cognitive Examination (M-ACE). A total of 304 participants were recruited for this questionnaire validation. Information for M-EASI was obtained from a reliable informant.

Results:

The mean age of the sample was 70.04 years (standard deviation—7.33). The majority of them were males (58.6%) and educated up to primary school (42.4%), while the majority of the informants were sons/daughters/siblings (47.7%) and were females (73.7%). Taking M-ACE scores as the gold standard for diagnosing MNCD according to Diagnostic and Statistical Manual of Mental Disorders—Fifth Edition criteria, there were 162 cases of MNCD and 142 normal controls. Cronbach’s α was 0.91. At an optimal cut-off of 4.5, adequate sensitivity (77.8%), and specificity (75.4%) were observed. The positive predictive value was 78.6%, and the negative predictive value, 74.5%.

Conclusion:

M-EASI has adequate psychometric properties as a screening tool for MNCD.
‘Punishing those who do the wrong thing’: Enforcing destitution and debt through the UK’s family migration rules
Authors: Dickson Eve , Rosen Rachel
Published: December 2020

In 2012, the ‘no recourse to public funds’ (NRPF) condition was extended to long-standing migrant families in the UK who had previously achieved rights to residence and welfare through human rights mechanisms. Through close examination of policy, political statements, and media coverage, we make the case that the NRPF extension was – and continues to be – intentionally subjugating and punitive, most aptly understood as a policy of enforced destitution and debt imposed on negatively-racialised post-colonial subjects. In drawing out the implications of our argument, we point to time, destitution, and debt as core technologies of the UK’s migration regime, alongside everyday bordering, detention, and deportability. Denying support through NRPF serves to exclude putatively included migrants while normalising conditional approaches to social support. Our article reveals why moral arguments against NRPF based on destitution fail and suggests that challenging welfare bordering requires a more systemic appraisal of policy frames, intentions and effects.
Predictors of postoperative atrial fibrillation persisting beyond hospital discharge after coronary artery bypass grafting
Authors: El-Essawi Aschraf , Abdelhalim Ahmed , Groeger Steffen , Breitenbach Ingo , Brouwer Rene , Kück Fabian , Harringer Wolfgang
Published: December 2020

Objective:

Minimal invasive extracorporeal circuits (MiECC) have been associated with a significant reduction in the incidence of postoperative atrial fibrillation (AF). Nevertheless, AF remains one of the most common complications following elective primary coronary artery bypass grafting (CABG). The aim of this study was to identify the predictors of AF persisting beyond the hospital stay in elective primary CABG patients.

Methods:

We conducted a retrospective analysis for the predictors of AF that persisted beyond discharge between all patients who received an elective isolated CABG in our institution between 2009 and 2014. Patients with a positive history for intermittent or persistent AF were excluded from the analysis. Almost all patients were discharged to a rehabilitation facility where they stayed for 3 to 4 weeks postoperatively. At rehab approximately 91% of them received Holter monitoring at least once prior to their discharge.

Results:

A total of 770 patients were included in the analysis of which 763 patients survived the in-hospital stay. The incidence of AF at hospital discharge was 4.2% (32/763) while that on Holter monitor at Rehab was 1.5% (10/685). Age and the type of extracorporeal circuit (ECC) utilized were the only significant predictors for both AF at discharge ( p < 0.01 both) and on Holter monitor in rehab ( p < 0.01 and 0.02, respectively). This was also confirmed on multivariate analysis.

Conclusion:

Our findings show that the benefits of MiECC regarding the incidence of postoperative AF persist beyond hospital discharge. They may thus positively influence the outcomes of patients beyond the early postoperative period.
Development and psychometric validation of the family-centered multidimensional outcome measure for pediatric palliative care targeted to children with severe neurological impairmentis—A multicenter prospective study
Authors: Pelke Sophie , Wager Julia , Claus Benedikt B. , Zernikow Boris , Reuther Mandira
Published: December 2020

Background:

Comprehensive outcome measurement in pediatric palliative care focusing on the entire unit of care, that is, the affected child and its family, is crucial to depict treatment effects. Despite its increasing relevance, no appropriate multidimensional outcome measures exist for the largest patient group in this field, namely children with severe neurological impairments.

Aim:

The aim of this study was to develop and validate a family-centered multidimensional outcome measure for pediatric palliative care patients with severe neurological impairment that encompasses the entire unit of care.

Design:

Based on results of a qualitative study, the questionnaire was developed by consensus-based generation of questions. It was validated in a multicenter prospective study employing exploratory and confirmatory factor analyses as well as reliability and item analyses.

Setting:

A total of 11 pediatric palliative care teams across Germany aided in the recruitment of study participants. Questionnaires were answered by 149 parents of children with severe neurological impairment and 157 professional caregivers.

Results:

The exploratory factor analysis of parent data revealed a 6-factor structure of the questionnaire representing: symptoms, the child’s social participation, normalcy, social support, coping with the disease and caregiver’s competencies. This structure was verified by a confirmatory factor analysis of professional caregiver data. Five separate items regarding siblings, partners, and further symptoms not applicable for all patients were added to ensure full multidimensionality.

Conclusion:

A validated outcome tool for severely neurologically impaired pediatric palliative care patients, the FACETS-OF-PPC, now exists. Due to its concise length and appropriate psychometric properties, it is well suited for clinical application.
Offshore wind energy potential for Bahrain via multi-criteria evaluation
Authors: Elgabiri Mohamed , Palmer Diane , Al Buflasa Hanan , Thomson Murray
Published: December 2020

Current global commitments to reduce the emissions of greenhouse gases encourage national targets for renewable generation. Due to its small land mass, offshore wind could help Bahrain to fulfil its obligations. However, no scoping study has been carried out yet. The methodology presented here addresses this research need. It employs analytical hierarchy process and pairwise comparison methods in a geographical information systems environment. Publicly available land use, infrastructure and transport data are used to exclude areas unsuitable for development due to physical and safety constraints. Meteorological and oceanic opportunities are ranked and then competing uses are analyzed to deliver optimal sites for wind farms. The potential annual wind energy yield is calculated by dividing the sum of optimal areas by a suitable turbine footprint to deliver maximum turbine number. In total, 10 favourable wind farm areas were identified in Bahrain’s territorial waters, representing about 4% of the total maritime area, and capable of supplying 2.68 TWh/year of wind energy or almost 10% of the Kingdom’s annual electricity consumption. Detailed maps of potential sites for offshore wind construction are provided in the article, giving an initial plan for installation in these locations.
Interdialytic weight gain of less than 2.5% seems to limit cardiac damage during hemodialysis
Authors: Goto Junko , Forsberg Ulf , Jonsson Per , Matsuda Kenichi , Nilsson Bo , Nilsson Ekdahl Kristina , Henein Michael Y , Stegmayr Bernd G
Published: December 2020

Aims:

To investigate if a single low-flux HD induces a rise in cardiac biomarkers and if a change in clinical approach may limit such mechanism.

Material and methods:

A total of 20 chronic HD patients each underwent three different study-dialyses. Dialyzers (low-flux polysulfone, 1.8 sqm) had been stored either dry or wet (Wet) and the blood level in the venous chamber kept low or high. Laboratory results were measured at baseline, 30 and 180 min, adjusted for the effect of fluid shift. Ultrasound measured microemboli signals (MES) within the return line.

Results:

Hemodialysis raised cardiac biomarkers ( p < 0.001): Pentraxin 3 (PTX) at 30 min (by 22%) and at 180 min PTX (53%), Pro-BNP (15%), and TnT (5%), similarly for all three HD modes. Baseline values of Pro-BNP correlated with TnT (rho = 0.38, p = 0.004) and PTX (rho = 0.52, p < 0.001). The changes from pre- to 180 min of HD ( delta-) were related to baseline values (Pro-BNP: rho = 0.91, p < 0.001; TnT: rho = 0.41, p = 0.001; PTX: rho = 0.29, p = 0.027). Delta Pro-BNP (rho = 0.67, p < 0.001) and TnT (rho = 0.38, p = 0.004) correlated with inter-dialytic-weight-gain (IDWG). Biomarkers behaved similarly between the HD modes. The least negative impact was with an IDWG ⩽ 2.5%. Multiple regression analyses of the Wet-High mode does not exclude a relation between increased exposure of MES and factors such as release of Pro-BNP.

Conclusion:

Hemodialysis, independent of type of dialyzer storage, was associated with raised cardiac biomarkers, more profoundly in patients with higher pre-dialysis values and IDWG. A limitation in IDWG to <2.5% and prolonged ultrafiltration time may limit cardiac strain during HD, especially in patients with cardiovascular risk.
A target-oriented algorithm for maintaining serum calcium stability automatically in regional citrate anticoagulation
Authors: Sheng Ruan-Mei , Zhao Wen-Biao , Huang Li-Hong , Chen Jian-Qin , Dai Zhen-Juan , Wang Xue-Min
Published: December 2020

Background:

Regional citrate anticoagulation (RCA) for renal replacement therapy is widely practiced in critically ill patients. However, concern exists regarding its labor-intensiveness for monitoring and the associated hypocalcemia. In this study, we provided an algorithm for prescribing RCA and evaluated its safety in patients.

Methods:

During 18 hemofiltration treatments with calcium-free replacement solution, participants were randomized to receive algorithm-based or trial-and-error RCA protocol. The effluent volume, post-filter and in vivo ionized calcium (iCa), and calcium in the sera and effluents were periodically measured at an interval of 1 to 2 h.

Results:

For patients received algorithm-based RCA protocol, no one had a serum iCa less than 0.9 mmol/L, and none needed calcium supplement adjustment to maintain serum calcium stability. For patients accepted trial-and-error protocol, all patients had a serum iCa below 0.9 mmol/L, their serum iCa and calcium levels fluctuated dramatically, and all patients need additional calcium supplement adjustment during RCA. None of the participants showed a post-filter iCa > 0.4 mmol/L.

Conclusion:

We provided a safe algorithm for calculating calcium supplementation doses that could maintain serum calcium stability without additional adjustment during RCA.
Depressive Symptoms and Multimorbidity: Is There an Association for Older Black Americans?
Authors: Cho Seungjong , Hamler Tyrone C.
Published: December 2020

Objectives: Many existing studies have reported a higher prevalence of depressive symptoms among older Black Americans. They also experience a disproportionate burden of multimorbidity, the presence of multiple chronic conditions. Therefore, this study was to identify the association between depressive symptomatology and multimorbidity among older Black Americans. Methods: This study analyzed the 2014 Health and Retirement Study ( N = 1206). A negative binomial regression was applied to assess the association between multimorbidity and depressive symptomatology. Results: Higher levels of chronic health problems were associated with higher levels of depressive symptomatology among older Black Americans ( Incidence rate ratio = 1.093; p = .002). Lower self-reported health, lower income, and lower educational attainment were also related to higher depressive symptoms. Discussion: Older Black Americans experience vulnerability on multiple levels, and shouldering additional psychosocial and financial burdens adds to already established physical health disparities. This requires critical attention from both practice and policy.
Children’s bodies and material culture: A study of children’s physical activities based on games
Authors: Garnier Pascale
Published: December 2020

Within a socio-anthropological framework, this paper studies how the relations between children’s bodies and material culture are related to age and gender identities. The empirical study involves nine focus groups of children playing a card game created for this research. The results illustrate how boys and girls favor different characteristics of these artifacts. They shed light on how this material culture provides symbolic resources for children relationships and performs what their bodies are and will be able to do.
‘We Don’t Have the Same Opportunities as Others’: Shining Bourdieu’s Lens on UK Roma Migrants’ Precarious (Workers’) Habitus
Authors: Harrison Patricia , Collins Helen , Bahor Alexandra
Published: December 2020

According to a 2019 UK government report, Roma had the ‘worst employment outcomes’ of any ethnic group in the UK with similar evidence in Europe. Roma are in the growing flexible, mobile workforce that constitute precarious, insecure workers. Based on a qualitative in-depth study of these precarious workers, and utilising Bourdieu’s concepts, we show the impact of flexploitation, while sharing Roma’s habitus and capitals that distinguish and challenge the dominant homogenous narrative about the response to precarity. We argue that Roma, owing to their long-standing, symbiotic relationship with precarity, compounded by centuries-old persecution, offer insights into the lived experience of precarious workers. While not diminishing the impact of flexploitation, we culminate with our claim that Roma possess a precarious habitus and, as such, are a ‘fish in water’ with a distinguishing feature of ‘social capital on the move’.
An effective heterogeneous whole-heart mathematical model of cardiac induction system with heart rate variability
Authors: Elkaranshawy Hesham A. , Ali Ahmed M. E. , Abdelrazik Ismail M.
Published: December 2020

The main objective of this research work is to develop an effective mathematical model of cardiac conduction system using a heterogeneous whole-heart model. The model is in the form of a system of modified Van der Pol and FitzHugh-Nagumo differential equations capable of describing the heart dynamics. The proposed model extends the range of normal and pathological electrocardiogram (ECG) waveforms that can be generated by the model. The effects of the respiratory sinus arrhythmia (RSA) and the Mayer waves (MW) are both incorporated to modulate the intrinsic frequency of the main oscillator that represents the sinoatrial node. Also, three pathological conditions are incorporated into the model. The heart rate variability (HRV) phenomenon is incorporated into the synthetic ECGs produced which yields valuable information about the cardiovascular health and the performance of the autonomic nervous system. The spectral analysis of the generated RR tachogram delivers power spectrums that resemble those obtained from real recordings. Also, the proposed model generates synthetic ECGs that characteristic the three considered pathological conditions, namely, the tall T wave, the ECG with U wave, and the Wolff-Parkinson-White syndrome. In general, the significance of this research work is in developing a mathematical model that represents the interactions between different pacemakers and allows analysis of cardiac rhythms. To show the effectiveness and the accuracy of the presented model, the results are compared to published results. The proposed model can be a useful tool to study the influences of different physiological conditions on the profile of the ECG. The synthetic ECG signals produced can be used as signal sources for the assessment of diagnostic ECG signal processing devices.
Anti-noise model-free adaptive control and its application in the circulating fluidized bed boiler
Authors: Dong Na , Lv Wenjin , Zhu Shuo , Li Donghui
Published: December 2020

Model-free adaptive control has been developed greatly since it was proposed. Up to now, model-free adaptive control theory has become mature and tends to be an effective solution for complex unmodeled industrial systems. In practical industrial processes, most control systems are inevitably accompanied by noise that will result in indelible error and may further cause inaccurate feedback to the output. In order to solve this kind of problem with model-free technique, this article incorporates an improved tracking differentiator into model-free adaptive control. After that, the anti-noise model-free adaptive control method with complete convergence analysis is proposed. Meanwhile, numerical simulation proves that the improved control method can quickly track a given signal with good resistance to noise interference. Finally, the effectiveness and practicability of the proposed algorithm are verified by experiments through the control of drum water level of circulating fluidized.
Reliability assessment and seismic control of irregular structures by magnetorheological fluid dampers
Authors: Bagherkhani Ali , Baghlani Abdolhossein
Published: December 2020

The catastrophic damages of past earthquakes show that irregular structures are more vulnerable to seismic excitation. On the other hand, dynamic responses depend on the severity of irregularity which is hard to be determined precisely. In this study, performance and reliability of magnetorheological (MR) fluid dampers in controlling torsional-lateral responses of irregular structures are evaluated. In this regard, plan-asymmetry is studied by considering mass eccentricity; whereas vertical-irregularity is investigated by creating mass difference in adjacent stories of the structure. The performance of MR dampers in seismic control of the structure is then evaluated for passive and semi-active control scenarios. The reliability of the structure-MR damper system is then studied by considering uncertainties in severity of irregularities using the Monte Carlo simulation method. Six types of limit state function are defined and the reliability of the system for controlling the desired responses are derived. The results show satisfactory performance of MR dampers in controlling coupled torsional-lateral responses of the structure in which semi-active control system outperforms the passive control system. The results also confirm that the performance of the control system highly depends on the structure irregularity which should be taken into account for design of a safe and reliable structure.
Irregular vascular network identified with OCT-A in angioid streaks: A probable predictor of active choroidal neovascularization (case series)
Authors: El Matri Khaled , Falfoul Yousra , Chebil Ahmed , Amoroso Francesca , Bouraoui Rim , El Matri Leila
Published: December 2020

Purpose:

To evaluate the risk of active choroidal neovascularization (CNV) in presence of deep irregular vascular network (IVN) in eyes with angioid streaks (AS).

Methods:

Observational case series including three treatment-naive eyes with angioid streaks and IVN, without CNV. Patients were followed-up during 18 months with multimodal imaging including structural optical coherence tomography (OCT) and OCT Angiography (OCT-A) to detect possible neovascular complication.

Results:

On OCT-A, IVN was detected as a peripapillary and/or macular high-flow lesion, filling the spaces between the angioid streaks in the outer retina slab. Repeated OCT-A could detect an active CNV emerging from the IVN, as a high-flow rich anastomotic vascular network with a perilesional dark halo. Patient was treated with intravitreal injections of Bevacizumab on a Pro Re Nata regimen, with a decreased CNV area and lower vascular density on control OCT-A.

Conclusion:

OCT-A shown to be helpful in detecting the presence of IVN in asymptomatic eyes with AS during a routine examination. In our series, the IVN seems to be predictor of active CNV, needing a close surveillance and frequent follow-up to allow early treatment upon CNV activation.
Attitudinal and social predictors of adherence to oral endocrine therapy: A psychometrically-informed model
Authors: Rivers Alannah Shelby , Sanford Keith , Elkins Gary , Carpenter Janet S , Rand Kevin L , Bartlett Ellis Rebecca J
Published: December 2020

There is a need for a psychometrically-informed model identifying attitudinal and social factors explaining adherence to oral endocrine therapy (OET) for women with hormone receptor positive breast cancer. This study tested a model with variables selected by stringent psychometric criteria, including attitudes about benefit and burden, patient-practitioner alliance and confusion, and positive and negative interpersonal interactions. Self-report scales were completed by 150 current or past OET users. Fourteen correlations and six mediated pathways implied by the model were tested. All hypothesized associations were significant. This preliminary study suggests the model is a valuable framework for OET adherence research and intervention.
Using an urban child health index to detect intra-urban disparities in Sweden
Authors: Kåks Per , Målqvist Mats
Published: December 2020

Aims:

Children’s health is affected by the environment in which they live and grow. Within Sweden’s urban areas, several city districts can be classified as socio-economically disadvantaged. This article describes the creation of a child health index to visualise disparities within and between Sweden’s three major cities, and how these relate to indicators of demography and socio-economic status.

Methods:

Data were collected for seven child health indicators and seven socio-economic and demographic indicators from the Swedish Pregnancy Register, Child Health Services and Statistics Sweden. An index was created from the health indicators using principal component analysis, generating weights for each indicator. Correlations between index outcomes and socio-economic and demographic indicators were analysed using linear regression.

Results:

The largest variance in index values could be seen in Stockholm followed by Malmö, and the poorest mean index outcome was seen in Malmö followed by Gothenburg. The largest intra-urban percentage range in health indicators could be seen for tobacco exposure at 0–4 weeks (0.8–33.9%, standard deviation ( SD)=8.8%) and, for the socio-economic and demographic indicators, foreign background (19.9–88.5%, SD=19.8%). In the multivariate analysis, index outcomes correlated most strongly with foreign background ( R2=0.364, p=0.001).

Conclusions:

Children’s health follows a social gradient and a pattern of ethnic segregation in Swedish cities, where it can be visualised using an index of child health. The resulting map highlights the geographical distribution of these disparities, and displays in which city districts child health interventions may be most needed.
‘You should see a doctor’, said the robot: Reflections on a digital diagnostic device in a pandemic age
Authors: Haase Christoffer Bjerre , Bearman Margaret , Brodersen John , Hoeyer Klaus , Risor Torsten
Published: December 2020

Aims:

In three days at the beginning of the COVID-19 pandemic, the Copenhagen Emergency Medical Services developed a digital diagnostic device. The purpose was to assess and triage potential COVID-19 symptoms and to reduce the number of calls to public health-care helplines. The device was used almost 150,000 times in a few weeks and was described by politicians and administrators as a solution and success. However, high usage cannot serve as the sole criterion of success. What might be adequate criteria? And should digital triage for citizens by default be considered low risk?

Methods:

This paper reflects on the uncertain aspects of the performance, risks and issues of accountability pertaining to the digital diagnostic device in order to draw lessons for future improvements. The analysis is based on the principles of evidence-based medicine (EBM), the EU and US regulations of medical devices and the taxonomy of uncertainty in health care by Han et al.

Results:

Lessons for future digital devices are (a) the need for clear criteria of success, (b) the importance of awareness of other severe diseases when triaging, (c) the priority of designing the device to collect data for evaluation and (d) clear allocation of responsibilities.

Conclusions:

A device meant to substitute triage for citizens according to its own criteria of success should not by default be considered as low risk. In a pandemic age dependent on digitalisation, it is therefore important not to abandon the ethos of EBM, but instead to prepare the ground for new ways of building evidence of effect.
Populist ideas on social media: A dictionary-based measurement of populist communication
Authors: Gründl Johann
Published: December 2020

This article presents a dictionary-based measurement of populist communication that reaches citizens directly through social media in German. The studied populist messages reflect ideational definitions of populism. Thus, populist messages appeal to the people, dismiss the elites as appalling, or highlight the people’s right to unfettered rule. Despite German-speaking countries offering a variety of populist parties, existing automated approaches are rarely applicable to German texts. Furthermore, they are not tailored to social media and often focus only on anti-elitism. I vastly improved existing dictionaries by analyzing populist ideology in its entirety, including people-centrism and the demand for people’s sovereignty. The article showed how known populist parties in Austria, Germany, and Switzerland spread these messages to a great extent on social media. Furthermore, I was able to highlight intra-party differences. Finally, the article discusses different aspects of validity and shows that the proposed approach offers high convergent validity and split-half reliability.
Trust in open data applications through transparency
Authors: Wiencierz Christian , Lünich Marco
Published: December 2020

Open data provide great potential for society, for example, in the field of smart cities, from which all citizens might profit. The trust of these citizens is important for the integration of various data, like sensitive user data, into an open data ecosystem. In the following study, we analyzed whether transparency about the application of open data promotes trust. Furthermore, we formulated guidelines on how to create transparency regarding open data in an ethical way. Using an open-data-based fictitious smart city app, we conducted an experiment analyzing to what extent communication of the technical open data application process and the ethical self-commitment for the transparent communication of data application affect trust in the app’s provider. The results indicate that the more information users obtain regarding the use of open data, the more trustworthy they perceive the app provider to be, and the more likely they are to use the app.
Perceptions versus performance: How routines, norms and values influence journalists’ protest coverage decisions
Authors: Harlow Summer , Brown Danielle K.
Published: December 2020

Protest paradigm researchers theorize that protests are delegitimized in news coverage because of journalistic culture and practices. This study explores the degree to which norms, routines, values and perceptions explain coverage patterns of protest. This mixed-methods study utilizes self-reflections from a survey of US journalists in four regions, alongside a content analysis of their coverage. Our study highlights how objective-observer role conceptions, routines driven by newsworthiness, and a perception-performance gap help explain protest coverage patterns. Importantly, journalists believed they did a better job covering protests than the content analysis showed, raising questions about what protest coverage should look like.
Everyday experiences of people living with dementia and their carers relating to oral health and dental care
Authors: Curtis Sarah A , Scambler Sasha , Manthorpe Jill , Samsi Kritika , Rooney Yvonne M , Gallagher Jennifer E
Published: December 2020

Little is known about how community-dwelling people with dementia, as well as their carers, look after their oral health and use dental care. This exploratory study aimed to explore the beliefs, experiences and practices about oral health of people living with dementia and their carers. We used an ethnographic qualitative approach conducting face-to-face interviews at home with people living with dementia and/or carers. Interview data and field notes were analysed thematically using framework methods. We approached volunteers registered with the online UK. Join Dementia Research network from whom a total of 17 participants were recruited in 2018. Five interviews were conducted with carers alone, two with a person living with dementia alone, and five with a carer and person with dementia jointly. Three main themes emerged: oral health is not prioritised; access to dental care is shaped by increasing disability; and the importance of continuity of care. While people living with dementia and their carers may view oral health important once prompted, many reported difficulties in undertaking or assisting with daily self-care and accessing dental services, particularly as dementia progresses. We draw out implications for the organisation and delivery of public and private dental services.
What is the present role for general practitioners in dementia care? Experiences of general practitioners, patients and family carers in Portugal
Authors: Balsinha Conceição , Iliffe Steve , Dias Sónia , Freitas Alexandre , Grave Joana , Gonçalves-Pereira Manuel
Published: December 2020

Background

Governments are being challenged to integrate at least part of dementia care into primary care. However, little is known about the current role of general practitioners (GPs) regarding dementia care, especially in countries that do not have dementia strategies in place. The aim of this study was to explore the experiences of GPs, persons with dementia and their family carers in Portuguese primary care settings, to better understand GPs’ contribution to dementia care.

Methods

A qualitative interview study of participants recruited from six practices in different social contexts within the Lisbon metropolitan area was carried out. Purposive sampling was used to recruit GPs, persons with dementia and carers. Interviews with GPs explored dementia care comprehensiveness, including satisfactory and challenging aspects. Interviews with patients and carers explored the experience of talking to GPs about cognitive impairments and related difficulties and the type of help received. Thematic analysis of interview transcripts was carried out using the framework approach.

Results

Five major themes were identified: GPs have a limited contribution to dementia care, the case of advanced dementia, doctor–patient relationships, doctor–carer relationships and management of chronic conditions other than dementia.

Conclusion

General practitioners seemed to contribute little to dementia care overall, particularly regarding symptom management. The exception was patients with advanced stages of dementia, given that specialists no longer followed them up. Remarkably, GPs seemed to be alone within primary care teams in providing dementia care. These findings strongly suggest that Portuguese primary care is not yet prepared to comply with policy expectations regarding the management of dementia.
Data and visual displays in the Journal of Ecology 1996–2016
Authors: Friedman Alon
Published: December 2020

Scholars in scientific disciplines face unique challenges in the creation of visualizations, especially in publications that require insights derived from analyses to be visually displayed. The literature on visualizations describes different techniques and best practices for the creation of graphs. However, these techniques have not been used to evaluate the impact of visualizations in academic publications. In the field of ecology, as in other scientific fields, graphs are an essential part of journal articles. Little is known about the connections between the kind of data presented and domain in which the researchers conducted their study that together produces the visual graphics. This study focused on articles published in the Journal of Ecology between 1996 and 2016 to explore possible connections between data type, domain, and visualization type. Specifically, this study asked three questions: How many of the graphics published between 1996 and 2016 follow a particular set of recommendations for best practices? What can Pearson correlations reveal about the relationships between type of data, domain of study, and visual displays? Can the findings be examined through an inter-reliability test lens? Out of the 20,080 visualizations assessed, 54% included unnecessary graphical elements in the early part of the study (1996–2010). The most common type of data was univariate (35%) and it was often displayed using line graphs. Twenty-one percent of the articles in the period studied could be categorized under the domain type “single species.” Pearson correlation analysis showed that data type and domain type was positively correlated ( r = 0.08; p ≤ 0.05). Cohen’s kappa for the reliability test was 0.86, suggesting good agreement between the two categories. This study provides evidence that data type and domain types are equally important in determining the type of visualizations found in scientific journals.
The rise of Baidu, Alibaba and Tencent (BAT) and their role in China’s Belt and Road Initiative (BRI)
Authors: Su Chunmeizi , Flew Terry
Published: December 2020

The Chinese digital technology giants, Baidu, Alibaba and Tencent (BAT), dominate over their competitors in China across platforms that include e-commerce, digital entertainment, e-finance and artificial intelligence (AI). To understand BAT’s corporate power and their strategic role working with the government – in this case, their involvement in the Belt and Road Initiative (BRI) – this paper unveils the capabilities of these three oligopolies and discusses their international expansion in relation to the BRI. The BRI is being constructed on two layers, the physical and digital infrastructure, and the BAT are contributing to the latter. This paper examines the interrelations between BAT and the state through case studies, observing the tensions and potential contradictions arising from the reliance of the Chinese state on the BAT to build digital infrastructure, while the BAT seek to minimize direct state regulation for their data-driven business models.
The risk of polypharmacy, comorbidities and drug–drug interactions in women of childbearing age with multiple sclerosis
Authors: Frahm Niklas , Hecker Michael , Langhorst Silvan Elias , Mashhadiakbar Pegah , Haker Marie-Celine , Zettl Uwe Klaus
Published: December 2020

Background and Aims:

Multiple sclerosis (MS) is the most common neuroimmunological disease of the central nervous system in young adults. Despite recommended contraception, unplanned pregnancies can occur in women of childbearing age with MS. MS- and comorbidities-related multimedication in these patients represents a potential risk. We aimed to raise awareness regarding the frequency of polypharmacy and drug–drug interactions (DDIs) in female MS patients of childbearing age.

Methods:

Sociodemographic, clinical and pharmaceutical data were collected through patient records, clinical investigations and structured patient interviews of 131 women with MS. The clinical decision support software MediQ was used to identify potential DDIs. A medication and DDI profile of the study population was created by statistical analysis of the recorded data.

Results:

Of the 131 female MS patients, 41.2% were affected by polypharmacy (concurrent use of ⩾5 drugs). Polypharmacy was associated with higher age, higher degree of disability, chronic progressive MS disease course and comorbidities. With an average intake of 4.2 drugs per patient, a total of 1033 potential DDIs were identified. Clinically relevant DDIs were significantly more frequent in patients with polypharmacy than in patients without polypharmacy (31.5% versus 5.2%; Fisher’s exact test: p < 0.001).

Conclusion:

For the first time, a comprehensive range of potential DDIs in women of childbearing age with MS is presented. Polypharmacy is associated with the occurrence of clinically relevant DDIs. This shows the need for effective and regular screening for such interactions in order to prevent avoidable adverse effects.
Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma
Authors: Gupta Pragya , Furness Sebastian G. B. , Bittencourt Lucas , Hare David L. , Wookey Peter J.
Published: December 2020

Researchers are actively seeking novel targeted therapies for the brain tumour glioblastoma (GBM) as the mean survival is less than 15 months. Here we discuss the proposal that the calcitonin receptor (CT Receptor), expressed in 76–86% of patient biopsies, is expressed by both malignant glioma cells and putative glioma stem cells (GSCs), and therefore represents a potential therapeutic target. Forty-two per cent (42%) of high-grade glioma (HGG; representative of GSCs) cell lines express CT Receptor protein. CT Receptors are widely expressed throughout the life cycle of organisms and in some instances promote apoptosis. Which of the common isoforms of the CT Receptor are predominantly expressed is currently unknown, but a functional response to cell stress of the insert-positive isoform is hypothesised. A model for resistant malignancies is one in which chemotherapy plays a direct role in activating quiescent stem cells for replacement of the tumour tissue hierarchy. The putative role that the CT Receptor plays in maintenance of quiescent cancer stem cells is discussed in view of the activation of the Notch–CT Receptor–collagen V axis in quiescent muscle (satellite) stem cells. The pharmacological CT response profiles of four of the HGG cell lines were reported. Both CT responders and non-responders were sensitive to an immunotoxin based on an anti-CT Receptor antibody. The CALCR mRNA exhibits alternative splicing commonly associated with cancer cells, which could result in the atypical pharmacology exhibited by CT non-responders and an explanation of tumour suppression. Due to the inherent instability of CALCR mRNA, analysis of CT Receptor protein in patient samples will lead to improved data for the expression of CT Receptor in GBM and other cancers, and an understanding of the role and activity of the splice variants. This knowledge will aid the effective targeting of this receptor for treatment of GBM.
Chemo-immunotherapy as first-line treatment for small-cell lung cancer
Authors: Farid Saira , Liu Stephen V.
Published: December 2020

Small-cell lung cancer (SCLC) is a highly lethal subtype of lung cancer. Despite concerted efforts over the past several decades, there have been limited therapeutic advances. Traditional chemotherapy offers a high response rate and rapid symptomatic improvement, but its benefit is fleeting, and relapse is quick and unforgiving. Immunotherapy has delivered improved outcomes for patients with many cancers and there was compelling rationale for development in SCLC. While initial efforts with cytotoxic T-lymphocyte protein-4 inhibitors failed to improve upon chemotherapy alone, the addition of programmed death ligand-1 (PD-L1) inhibitors to first-line chemotherapy finally provided long-awaited gains in survival. Atezolizumab, when added to carboplatin and etoposide, improved both progression-free survival and overall survival. Durvalumab, when added to platinum plus etoposide, similarly improved OS. Biomarker development has stalled as PD-L1 expression and tumor mutational burden have not been useful predictive biomarkers. However, based on the significant survival improvements, both atezolizumab and durvalumab were approved by the US Food and Drug Administration to be given with first-line chemotherapy, and these regimens represent the new standards of care for SCLC.
The association between immune-related adverse events and the prognosis of solid cancer patients treated with immunotherapy: a systematic review and meta-analysis
Authors: Xu Huilin , Xu Ximing , Ge Wei , Lei Jinju , Cao Dedong
Published: December 2020

Background:

Immune-related adverse events (irAEs) are common during immune checkpoint inhibitor (ICI) treatment and reported to be associated with good survival. This study evaluated the association between onset timing of irAEs and survival of cancer patients treated with ICIs.

Methods:

Databases including PubMed, Embase, and the Cochrane library were systematically searched to retrieve clinical studies assessing the relationship between irAEs and survival in cancer patients with ICIs. The overall response rate for treatment response and hazard ratio (HR) for overall survival (OS) and progression-free survival (PFS) were calculated using RevMan 5.3. Subgroup analysis in terms of cancer type, ICIs type, region, specific irAEs, accordingly.

Results:

A total of 34 studies were included. The HRs for OS and PFS in cancer patients with versus without irAEs were 0.57 [95% confidence interval (CI): 0.44, 0.74; p < 0.0001], and 0.50 (95% CI: 0.37, 0.67; p < 0.00001), respectively. The odds ratio for overall response in cancer patients with irAEs was 4.72 (95% CI: 3.48, 6.40; p < 0.00001) compared with those without irAEs. Subgroup analyses suggested that the prognostic role of irAEs was associated with cancer types and region, but not irAEs types. The landmark analysis of OS revealed that there is a non-proportional (early) effect of irAEs on OS in ICI-treated cancer patients (landmark >12 weeks, HROS = 1.08; 95% CI: 0.89, 1.30; p = 0.46).

Conclusion:

Our findings suggest that the occurrence of irAEs could be a prognostic factor for cancer patients who were treated with ICIs.