bluuebunny/crossref_metadata_2025 huggingface dataset:
KORIŠTENJE DIGITALNIH MEDIJA U OBRAZOVNOM PROCESU VISOKOŠKOLSKIH USTANOVA U BOSNI I HERCEGOVINI
Authors: Tešanović Sreten , Kukobat Lazo , Šobot Nataša , Hrstić Bojan
Published: November 2021

Ambijentalne promjene utiču na visoko obrazovanje, a karakterišu ga mobilnost nastavnog osoblja i studenata, sve veća prisutnost informacionih, modernih komunikacionih tehnologija i medija. Medije možemo posmatrati kao sredstva informisanja, obrazovanja i zabave. Korištenje digitalnih medija u komunikaciji potpomognuto je slikom, zvukom, animacijom koji djeluju udruženo na više čula, stvarajući tako potpunu informaciju. Budućnost savremenih obrazovnih sistema temelji se i na sposobnosti njihove primjene za samoučenje i samousavršavanje pomoću raznovrsnih digitalnih medija koji omogućavaju širok transfer znanja. Digitalni mediji imaju veliku mogućnost aktuelizacije i brz protok informacija, pa postizanje efektivnog učenja putem digitalnih medija i dalje predstavlja izazov savremenog obrazovanja. Stepen digitalizacije u Bosni i Hercegovini je svakako u porastu, iako ovaj proces nailazi na poteškoće izražene najviše u otporu ljudi da se priklone promjenama. Cilj istraživanja je utvrditi koliko se digitalni mediji koriste u nastavnom procesu na visokoškolskim ustanovama u Bosni i Hercegovini i utvrditi njihov uticaj na efektivnost učenja i usvajanja novih znanja. Prospektivno istraživanje je provedeno u mjesecu aprilu 2019. godine, a ispitanici su bili studenti i nastavno osoblje privatnih i državnih visokoškolskih ustanova. Rezultati provedenog istraživanja, na uzorku od 190 ispitanika pokazuju da je digitalizacija u viskoškolskom obrazovanju u porastu i da kombinovana nastava ima najbolje efekte za usvajanje novih znanja i vještina, te da upotreba digitalnih medija ima značajan uticaj u procesu obrazovanja i transferu znanja.
MEDIJSKE KOMPETENCIJE U ŠKOLI
Authors: Milošević Sanda
Published: November 2021

Potreba za digitalnim obrazovanjem još u ranom djetinjstvu danas je nesporna. Brojne inicijative i istraživački projekti odnose se na uspostavljanje digitalnog obrazovanja u školama. Korištenju interneta i savremenih medija u didaktičke svrhe potrebno je pristupiti sistemski i u okviru nastavnih planova i programa. Ovaj rad pokušava približiti rješenja na primjeru Njemačke i prikazati trenutno stanje kod nas. Digitalnom obrazovanju i informatici u okviru nastavnog programa potrebno je pristupiti interdisciplinarno i detaljno razjasniti sadržajna područja digitalnog obrazovanja. Digitalno obrazovanje trenutno nije definisano u nastavnim programima u osnovnoj školi. Proučava se u okviru brojnih predmeta, međutim, nije dodijeljen određenom predmetu. Vještine potrebne za rad u digitalnom svijetu izlaze iz okvira Osnova informatike, predmeta koji se izučava u osnovnoj školi.
REFORME, PROBLEMI I BUDUĆNOST EUROPSKE UNIJE
Authors: Petrović Željko
Published: November 2021

Europska unija je zajednica država europskog kontinenta koje su se ujedinile radi ostvarenja zajedničkih interesa. Europska unija je prošla kroz burne transformacije od svog nastanka pa sve do danas i te promjene su i danas u toku. Poseban izazov za Europsku uniju predstavlja njeno proširivanje na nove države, a posebno države istoka i juga Europe. Predmet analize u ovom radu jeste prvenstveno pitanje problema i izazova Europske unije koji su postojali u prošlosti, postoje danas i koji će se pojaviti u bližoj ili daljoj budućnosti. Rad posebnu pažnju obraća na trenutne probleme Europske unije koji se odnose na migrantsku krizu, te izlazak Ujedinjenog Kraljevstva iz Europske unije što će se reflektirati i na njenu budućnost. Rad će se osvrnuti na digitalno doba, te dostupnost informacija koje mijenjaju sliku same Europske unije. Istovremeno rad ukazuje na proces promjena koje postoje u samoj Europskoj uniji kao i na postojanje određenih neriješenih pitanja od kojih su mnoga još uvijek otvorena.
UPOTREBA KOLABORATIVNIH ALATA ZA PODRŠKU GRUPNOM DONOŠENJU ODLUKA
Authors: Muhamed Mrkaljević
Published: November 2021

U današnje vrijeme gotovo je nemoguće zamisliti poslovanje bez korištenja računara i novih tehnologija. Računar i internet postali su svakodnevnica, koja nam pruža određeni vid podrške u procesu poslovanja. Razvoj tehnologije nam omogućava da osim teksta i slike, koristimo i druge multimedijalne elemente – zvuk, video, različite simulacije, animacije i sl. Ne manje bitan faktor je i odabir alata i multimedijalnog softvera koji ćete koristiti za komunikaciju. Ovaj rad donosi osvrt i daje uvod u korištenje multimedije u poslovanju. Cilj je da se učesnicima sastanka obezbijedi željeni nivo komunikacije uz što bolje ostvarene rezultate pri donošenju poslovnih odluka, te što veće uštede u troškovima putovanja, noćenja i drugim rashodima koji se u takvom slučaju javljaju. Upotreba kolaborativnog softvera, danas je jedan od najpopularnijih metoda u kolaborativnom sistemu rada. Neki oblik kolaboracije integralni je dio gotovo svakog kolegija grupne saradnje. Uspon Weba kao nove računarske platforme mijenja paradigmu korištenja računara. Temelj tog novog okruženja je socijalna interakcija, komunikacija i kolaboracija. Iako se kolaborativna saradnja koristi već dugo u poslovanju, te recentne tehnološke promjene nude mu nove perspektive napretka. Za kompanije koje koriste video konferencije kao metod okupljanja svojih menadžera sa različitih mjesta, kao što je slučaj sa određenim bankama, web konferencije i virtuelni sastanci postale su dio svakodnevnice. Svima koji koriste virtualne tehnologije je veoma važan kriterijum da prostor u kome organizuju događaj ima podršku (opremu) za primjenu ovih tehnologija.
POGLED NA ZNAČAJ I AKTUELNOST RAČUNOVODSTVENIH INFORMACIONIH SISTEMA U SAVREMENOM POSLOVNOM OKRUŽENJU
Authors: Mitrović Aleksandra , Milašinović Marko
Published: November 2021

Informaciono-komunikaciona tehnologija je iz godine u godinu, svojim razvojem, transformisala način na koji preduzeća posluju. Kada govorimo konkretno o računovodstvu, može se istaći da je računovodstvo ostvarilo ogroman napredak zahvaljujući razvoju informaciono-komunikacione tehnologije.Cilj rada je sagledavanje značaja i aktuelnosti računovodstvenih informacionih sistema u savremenom poslovnom okruženju.Časopisi koji se bave problematikom računovodstvenih informacionih sistema pokazuju aktuelne teme ili oblasti istraživanja računovodstvenih informacionih sistema, sa stalnim naglaskom na razvoj i značaj novih tehnologija u računovodstvu. Takođe, na osnovu predmeta istraživanja i analize rezultata, otvoreno je više istraživačkih pitanja u vezi sa daljim pravcima istraživanja i mogućnosti sagledavanja važnosti i aktulenosti računovodstvenih informacionih sistema.
Acute frame coil migration during filling coil retrieval in a cerebral aneurysm embolization case: A possible result of a venturi effect?
Authors: Doron Omer , Meirowitz Eran , Abergel Eitan
Published: November 2021

Coil migration is a known complication of endovascular coiling of cerebral aneurysms. We report an acute coil migration occurring during coiling of an unruptured anterior choroidal aneurysm, while a separate coil was retrieved into the microcatheter concomitantly without direct contact between the coils. The “pulling” of a previously deployed stable coil is presented as an adverse effect that should be noted. This case exemplifies that not only direct entanglement or erroneous malposition can generate acute migration, but possibly, also alteration of physical forces during coil retrieval. A potential mechanism, similar to a venturi effect, caused by a quick suction within the microcatheter at its distal end, is suggested, and the clinical relevance of the case is discussed.
Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons
Authors: Biane Celia , Rückerl Florian , Abrahamsson Therese , Saint-Cloment Cécile , Mariani Jean , Shigemoto Ryuichi , DiGregorio David A , Sherrard Rachel M , Cathala Laurence
Published: November 2021

Synaptic transmission, connectivity, and dendritic morphology mature in parallel during brain development and are often disrupted in neurodevelopmental disorders. Yet how these changes influence the neuronal computations necessary for normal brain function are not well understood. To identify cellular mechanisms underlying the maturation of synaptic integration in interneurons, we combined patch-clamp recordings of excitatory inputs in mouse cerebellar stellate cells (SCs), three-dimensional reconstruction of SC morphology with excitatory synapse location, and biophysical modeling. We found that postnatal maturation of postsynaptic strength was homogeneously reduced along the somatodendritic axis, but dendritic integration was always sublinear. However, dendritic branching increased without changes in synapse density, leading to a substantial gain in distal inputs. Thus, changes in synapse distribution, rather than dendrite cable properties, are the dominant mechanism underlying the maturation of neuronal computation. These mechanisms favor the emergence of a spatially compartmentalized two-stage integration model promoting location-dependent integration within dendritic subunits.
Experimental evidence for delayed post-conflict management behaviour in wild dwarf mongooses
Authors: Morris-Drake Amy , Kern Julie M , Radford Andrew N
Published: November 2021

In many species, within-group conflict leads to immediate avoidance of potential aggressors or increases in affiliation, but no studies have investigated delayed post-conflict management behaviour. Here, we experimentally test that possibility using a wild but habituated population of dwarf mongooses (Helogale parvula). First, we used natural and playback-simulated foraging displacements to demonstrate that bystanders take notice of the vocalisations produced during such within-group conflict events but that they do not engage in any immediate post-conflict affiliative behaviour with the protagonists or other bystanders. We then used another playback experiment to assess delayed effects of within-group conflict on grooming interactions: we examined affiliative behaviour at the evening sleeping burrow, 30–60 min after the most recent simulated foraging displacement. Overall, fewer individuals groomed on evenings following an afternoon of simulated conflict, but those that did groomed more than on control evenings. Subordinate bystanders groomed with the simulated aggressor significantly less, and groomed more with one another, on conflict compared to control evenings. Our study provides experimental evidence that dwarf mongooses acoustically obtain information about within-group contests (including protagonist identity), retain that information, and use it to inform conflict-management decisions with a temporal delay.
The brain limit
Authors: Werth Alexander J , Corbett Joseph E
Published: November 2021

How fast the brain and muscles can respond to information about prey location constrains visual and echolocating predators in similar ways.
Sex difference analyses under scrutiny
Authors: Vorland Colby J
Published: November 2021

A survey reveals that many researchers do not use appropriate statistical analyses to evaluate sex differences in biomedical research.
Trevor Noah and the contingent politics of racial joking
Authors: Donian Jennalee , Holm Nicholas
Published: November 2021

This article takes up the transnational comedy career of Trevor Noah as a way to explore how the political work of racial comedy can manifest, circulate and indeed communicate differently across different racial-political contexts. Through the close textual analysis of two key comic performances –“The Daywalker” (2009) and “Son of Patricia” (2018), produced and (initially) circulated in South Africa and the USA, respectively – this article explores the extent to which Noah’s comic treatment of race has shifted between the two contexts. In particular, attention is paid to how Noah incites, navigates and mitigates potential sources of offence surrounding racial anxieties in the two contexts, and how he evokes his own “mixed-race” status in order to open up spaces of permission that allow him to joke about otherwise taboo subjects. Rejecting the claim that the politics of Noah’s comedy is emancipatory or progressive in any straightforward way, by means of formal analyses we argue that his comic treatment of race does not enact any singular politics, but rather that the political work of his racial humour shifts relative to its wider political contexts. Thus, rather than drawing a clear line between light entertainment and politically meaningful humour, this article argues that the political valence of racial joking can be understood as contingent upon wider discourses of race that circulate in national-cultural contexts.
Fandom versus citizenship: the “weirdisation” of politics
Authors: Chiaro Delia , Lobanov Nikita
Published: November 2021

This paper examines occurrences of humour in Twitter-fed celebrity-follower communities. Using a small, one-month sample of the Twitter feeds of 12 British celebrities, we examined political and humorous content of celebrity tweets and the first five responses from their followers. From this preliminary study, we found that the notion of “weirdisation” strongly emerges, together with the new conceptual tool of “shards of humour”.
Co-occurrence pattern of congeneric tree species provides conflicting evidence for competition relatedness hypothesis
Authors: Watanabe Shuntaro , Maesako Yuri
Published: November 2021

In plants, negative reproductive interaction among closely related species (i.e., reproductive interference) is known to hamper the coexistence of congeneric species while facilitation can increase species persistence. Since reproductive interference in plants may occur through interspecific pollination, the effective range of reproductive interference may reflects the spatial range of interspecific pollination. Therefore, we hypothesized that the coexistence of congeners on a small spatial scale would be less likely to occur by chance but that such coexistence would be likely to occur on a scale larger than interspecific pollination frequently occur. In the present study, we tested this hypothesis using spatially explicit woody plant survey data. Contrary to our prediction, congeneric tree species often coexisted at the finest spatial scale and significant exclusive distribution was not detected. Our results suggest that cooccurrence of congeneric tree species is not structured by reproductive interference, and they indicate the need for further research to explore the factors that mitigate the effects of reproductive interference.
AN EXPERIMENTAL STUDY TO EVALUATE THE HEPATOPROTECTIVE ACTIVITY OF NILITANDULIYADI LEHA IN PARACETAMOL INDUCED HEPATOTOXICITY IN WISTAR ALBINO RATS
Authors: Vijayan Sreekala , Kishore Jugal
Published: November 2021

Background: Paracetamol toxicity is currently the single most important cause for acute liver failure and is associated with significant number of deaths. Nilitanduliyadi leha is one among the formulation explained in the context of Vishahara yogas (anti-poisonous formulations) in the text Vishavaidya Jyotsnika. Objectives: To experimentally evaluate the hepatoprotective activity of nilitanduliyadi leha in paracetamol induced hepatotoxicity in Wistar albino rats. Methods: Albino Wistar rats of either sex weighing 200 – 250, g were selected and divided into four groups of six animals in each group (n = 6). Treatment was given for 7 days. Blood was drawn and sent for tests and important organs like liver and kidney were dissected out, cleaned to remove extraneous tissues, blotted to remove blood stain and weighed. A piece of liver tissue was preserved in 10% formalin for histopathological processing. Results: The formulation has helped in balancing the biochemical parameters studied almost as efficiently as the standard drug. In the antioxidant study also, the drug has given good results and shows even slightly more effective than the standard drug. The histopathology study also reveals mild protection and regeneration of tissues by the effect of test drug. Conclusion: This present study proves that the formulation is having a comparable hepato protective activity with that of silymarin.
Opinion and Expectations of Beneficiaries towards Training Programmes of KVKs: Gender Analysis
Authors: Sulekha . , Yadav Kamlesh Kumar , Gupta Dileep , Nath Prem , Rajbhar Arun Kumar , Mehta Sudershan
Published: November 2021

Study was conducted to know the opinion and expectations of beneficiaries towards training programmes of KVKs in Haryana. Agro climatically Haryana is divided into two zones i.e., western and eastern zone. Based on the year of establishment, four KVKs two each funded by ICAR from western and eastern zone of Haryana, functioning for the last five years and where maximum number of rural women participated in their training programmes were selected. These KVKs were Bhiwani and Fatehabad from western zone, Rohtak and Jhajjar from eastern zone. The opinion of male and female beneficiaries were studied through five specific aspects of training viz., training programme, course content, time and duration, physical facilities, evaluation and supporting activities. For analyzing the expectations of the beneficiaries, a schedule was developed. Results revealed that out of both the zones, majority of male and female beneficiaries had high opinion level about all the four specific training aspects viz; training programme (26.0% male and 20.5% female), course content (24.0% male and 21.5% female), time and duration (22.5% male, 20.0% female) and physical facilities (26.0% male and 26.5% female). In case of evaluation and supporting activities where they had medium (27.5% male and 19.5% female) level of opinion regarding training programmes. Overall level of opinion of respondents towards training programmes was medium (26.0% male and 20.5% female) followed by high (24.5% male and16.5% female) and low (7.0% male and 5.5% female). Whereas, level of expectation of beneficiaries for training programmes was high (33.0% male and 21.5% female) followed by medium (20.5% male and 15.0% female) and low (4.5% male and 5.5% female).
Extent of Utilization of Various Government Tribal Development Schemes by Primitive Tribes Living in Biodiversity Zone of Nilgiri District in Tamil Nadu
Authors: Rafeeq Foumy N. , Rajasekaran R.
Published: November 2021

Biodiversity hotspots have set up to protect at least 10 per cent of world's ecological regions in order to conserve biodiversity and safeguard many facilities provided by natural ecosystems. Biosphere Reserves are representative areas of natural and cultural landscapes that span a large area of agricultural, marine, or coastal ecosystems, or a combination of them, as well as representative bio-geographic domains or kingdoms. The Nilgiri Biosphere Reserve has richness and diversity, to protect it, the district has been declared as “Organic district” on July 2019. It is also the home to a wide range of human cultural diversity and especially the primitive and vulnerable tribes live in these areas. They are the designated tribal settlers identified by the government and these have their own religious believes, culture and traditions which is extremely different from others customs. They are called as "Adivasi" or "Aboriginals". So as to improve their life style and lead a better life like others, central government along with state government had bought several development schemes and plans under Ministry of tribal affairs. The Tribal Development Plan (TDP) was developed to proactively solve tribal issues and provide culturally compatible solutions, specifically considering indigenous people. The main objective of this study is the adoption level of government tribal development schemes and plans among the primitive tribes living in the biodiversity zone of Nilgiri biosphere. Thus the vulnerable and primitive tribal societies of like Toda, Kota, Kurumba, Paniya, Kattu naickan and Irular of Nilgiri district have been chosen for the investigation with the sample size of 120, in which 20 from each tribes have been chosen. Pre-tested and well-structured interview schedule have been made and thereby undergone survey. Thus it provided an overall picture about the level of adoption about various government tribal development schemes for their betterment and upliftment in among Nilgiri tribes.
Role of Major Weather Parameters in the Production of Black Pepper in Kerala
Authors: S. Nair Nayana , Thilagavathi M. , Prahadeeswaran M. , Duraisamy M. R.
Published: November 2021

Aim: The present study intends to analyse the influence of weather parameters on the production of black pepper in six major pepper producing districts of Kerala, the Indian state which contributes a considerable share to national spice exports.

Methodology: This research is based on secondary data which is limited to six major black pepper producing districts of Kerala which were chosen based on their contribution to total production of the state 2020. More than 50% of the production was from Idukki district followed by Wayanad (8%), and around 3 to 3.5% from Kannur, Kasargod, Kottayam and Kollam districts respectively. Annual precipitation, Relative humidity, Maximum and Minimum temperatures were the parameters taken into consideration along with production data of over 15 years (2005-2019) which was then subjected to regression analysis using panel data.

Results: According to the results, significant reduction in production by 2.52% and 1.88% was recorded for unit increase maximum (P= 0.047) and minimum temperature (P=0.03) respectively. Likewise, unit rise in relative humidity and rainfall was responsible for decrease

In production by 1.1%, and 0.07% respectively though they were reported to be insignificant.

Conclusion: From the present study, it could be concluded that maximum and minimum temperatures were found to be significant in affecting the production of black pepper. However the negative regression coefficients obtained for other factors like rainfall and relative humidity implied its negative effect on production. In order to combat these variations, there is therefore, the need to create awareness to farmers in India on the need to adopt best farming practices in order to improve yield of this important crop.
A New Two-Parametric Maxwell-Rayleigh Distribution: Application to the Analysis of Engineering Data
Authors: Jallal Muzamil , Ahmad Aijaz , Tripathi Rajnee
Published: November 2021

In this study a new generalisation of Rayleigh Distribution has been studied and referred it is as “A New Two-Parametric Maxwell-Rayleigh Distribution”. This distribution is obtained by adopting T-X family procedure. Several distributional properties of the formulated distribution including moments, moment generating function, Characteristics function and incomplete moments have been discussed. The expressions for ageing properties have been derived and discussed explicitly. The behaviour of the pdf and Hazard rate function has been illustrated through different graphs. The parameters are estimated through the technique of MLE. Eventually the versatility and the efficacy of the formulated distribution have been examined through real life data sets related to engineering science.
Effect of Late Upward Tapping on the Productivity of the Metabolically Active Hevea brasiliensis Clone PB 260 in Southwestern Cote d'Ivoire
Authors: Kan Pulchérie Kouakou N’guessan , Perpetue Moro Affia , Moussa Diarrassouba , Malydie Lehi Irénée , Djézou Konan , Antoine Koffi , Hilaire Kouakou Tanoh , Samuel Obouayeba
Published: November 2021

In order to evaluate the improvement of rubber productivity of rubber trees by late upward tapping. A study was conducted at SCASO (Société Civile Agricole du Sud-Ouest) on the PB 260 clone of the active metabolic class. The experimental set-up is a Fisher block design with eight treatments and three replications. The treatments compared were bled in reverse in the eleventh year of harvest, in quarter spiral every 3, 4, 5 and 6 days, with stimulation frequencies of 6, 8, 10, 12 and 13 times a year. The parameters measured were rubber production, isodiametric growth, sensitivity to dry notching of trees and physiological profile. The results show that the different latex harvesting technologies improve the rubber productivity of PB 260 (5469 kg.ha-1.yr-1) with a low dry-nut rate (1.2%) and satisfactory radial vegetative growth (3.9cm.yr-1). The physiological profile of the trees is balanced, but the treatments significantly influenced the different parameters except sucrose. Trees bled in S/4U d3 gave better results due to their high yield with an acceptable dry notch rate. Late reverse tapping is therefore a good latex harvesting technology for improving rubber productivity after down tapping.
Evaluation of Cytotoxic Effects of Methanolic Extract and Fractions of Mirabilis jalapa (L.) Leaf
Authors: Azeez Sekinat Okikiola , Nifemi Olowu Aanuoluwapo , Godwin Anyim , Apata Joseph Tosin , Akinpelu Bolajoko Ayinke
Published: November 2021

This study examined the potential cytotoxicity of Mirabilis jalapa L. methanolic crude leaf extract and its fractions against brine shrimp nauplii (Artemia salina L.) and Allium cepa L. roots. The leaf extraction was done according to standard technique and crude extract was partitioned using n-hexane, water, ethyl acetate and butanol to obtain their respective fractions. Allium cepa root growth inhibition of M. jalapa methanolic crude extract and fractions were evaluated as well as brine shrimp lethality of the fractions based on standard methods. Also, phytochemical screening of the methanolic crude leaf extract was carried out according to standard methods. The result showed that M. jalapa methanolic crude leaf extract caused a significant reduction in cell mitotic index (32.96%) compared with the control (52.13%). The butanol fraction produced the highest mitotic inhibitory activity on A. cepa cell division at 0.3 mg/ml. Moreover, the butanol fraction produced the highest percentage lethality (LC50 1.45 μg/ml) against brine shrimp nauplii. There was a strong correlation between brine shrimp lethality and mitotic cell inhibition with butanol fraction as the most potent in both models. The methanolic leaf crude extract tested positive for alkaloids, cardiac glycosides, flavonoids, saponins, steroids, tanins and triterpenes. The methanolic crude extract of M. jalapa leaf and its fractions exhibited effective cytotoxic effect on A. cepa and brine shrimps. Butanol fraction, with the most cytotoxic activity among the tested extracts, demonstrates a promising source for novel anticancer agents.
Comparative Study of Spino-pelvic Parameters between Scoliotic versus Non-scoliotic Patients with Multi-level Degenerative Lumbar Spondylosis
Authors: Mohamed Mohamed Fathy Amer , El-Sayed El-Daw Sherif , El-Tantawy Ahmed El-Sayed , Shafik Saeid Mohammed
Published: November 2021

Degenerative lumbar scoliosis is a multi-planner deformity seen in the aging spine. Important parameters in the evaluation of balance of the degenerative lumbar scoliosis include spino-pelvic parameters such as the LL, SS, PI, and PT besides the coronal Cobb´s angle. In order to minimize the energy associated with maintaining upright posture, sagittal balance is necessary. Significant sagittal abnormality or imbalance is commonly related to poor functional scores across multiple domains.

Aim: The aim of this study was to investigate the role of the spino-pelvic parameters in the development of scoliosis in multi-level degenerative lumber spondylosis disease.

Patients and Methods: This cross-sectional study was carried out in Tanta University Hospitals. It included the first 100 patients who visited the outpatient orthopedic department clinic from April 2019.

Results: There was a statistically significant (p ≤ 0.05) increase in each of the PI, PT and cobb´s angle and a significant decrease in SS in multi-level DLS with scoliosis patients in correlation to multi-level DLS without scoliosis patients. There were no significant differences between LL in both studied groups.

Regarding the age, sex, BMI and occupation in the two studied groups, there were no statistically significant differences. There was a significant correlation between the sex and PT in patients with multi-level DLS without scoliosis, but there was no significant correlation between sex and other parameters in both groups. There wasn´t significant correlation between the two groups by increasing the age. Manual workers in scoliotic group show higher PT and smaller SS than in non-scoliotic group, which give a significant correlation between the occupation and these spino-pelvic parameters.

Conclusion: Importance of a thorough discussion of the risks of deformity progression weighed against the anticipated benefits with patient’s during clinical consultation return to the spino-pelvic parameters. Measurement of these spino-pelvic parameters can help in monitoring progression of disease in patients and allow physicians to provide better prevention, treatment and control.
Spectrophotometric and High Performance Liquid Chromatographic Determination of Carbamazepine in Tablets Dosage Form
Authors: Bulduk Ibrahim , Gungor Serdar
Published: November 2021

Today, millions of people suffer from epilepsy, one of the most common chronic neurological diseases worldwide. Carbamazepine is a first-line drug used in the treatment of epilepsy. High performance liquid chromatographic and spectrophotometric methods have been developed for the determination of carbamazepine in tablet dosage forms. UV spectrums were recorded in the wavelength range of 200-800 nm using methanol solvent, and the wavelength for determining carbamazepine was selected as 286 nm. LC analysis was performed using Agilent Extend-C18 column and mobile phase composed of KH2PO4 solution(pH: 3.5) and acetonitrile (40:60 v/v) at a flow rate of 1.2 mlmin-1. These analytical methods were validated in agreement with the International Conference on Harmonization (ICH) guidelines using the following analytical parameters: specificity, linearity, precision, accuracy, detection and quantification limits, and robustnes. Analytical methods showed wonderful linearity (r2>0.999) in the concentration range of 5-25 μg mL-1 for boths methods. Precision (R.S.D%<1.17) and recevery for both methods was in the range of 99-101%, which shows accuracy of these methods. These proposed methods were found to be accurate, reliable, fast, simple, The F-test and t-test were used to perform statistical comparison of these methods, and the results of both analytical methods indicated no significant difference. As a result, the proposed methods can be used to analyze carbamazepine in pharmaceutical formulations.
PERAN KEPALA SEKOLAH BERDASARKAN KEPEMIMPINAN KRISTEN YANG MENOLONG GURU SDTK KASIH KARUNIA KUPANG UNTUK MEMILIKI DISIPLIN ROHANI
Authors: Jovita Azalia Elmaivana
Published: November 2021

Kepemimpinan Kristen adalah kepemimpinan yang berlandaskan pada nilai-nilai Kristiani dan yang menjadikan Kristus sebagai teladan. Di sekolah Kristen yang menjadi pemimpin adalah kepala sekolah. Kepala sekolah SDTK Kasih Karunia Kupang sudah menjalankan peran pemimpin Kristen dalam menolong guru memiliki disiplin rohani sebagai pendidik, pemberi motivasi, dan pemimpin. Kepala sekolah memandang disiplin rohani sebagai hal yang penting, maka dari itu kepala sekolah harus membuat program yang menunjang disiplin rohani dan didukung oleh tindakan secara langsung. Penelitian ini bertujuan untuk mendeskripsikan peran kepala sekolah berdasarkan kepemimpinan Kristen untuk menolong guru memiliki disiplin rohani. Penelitian ini menggunakan pendekatan kualitatif deskriptif. Pengumpulan data yang dilakukan adalah observasi, peneliti melakukan observasi sebanyak 2 tahap. Tahap pertama dilakukan pada tanggal 11 Januari - 24 Januari, dan tahap kedua dilakukan dari bulan November - Desember. Pengumpulan data juga dilakukan secara wawancara, yang menjadi narasumber adalah kepala sekolah dan 3 orang guru SDTK Kasih Karunia Kupang. Hasil penelitian ini menunjukkan bahwa kepala sekolah telah menjalankan tiga peran sebagai pendidik, pemberi motivasi dan pemimpin. Dari ketiga peran tersebut dapat menolong guru untuk memiliki disiplin rohani.
Characteristics of Storm Surge by Forward Speed of Typhoon in the South Coast of Korea
Authors: Park Young Hyun , Park Woo-Sun
Published: November 2021

The damage caused by typhoons is gradually increasing due to the climate change recently. Hence, many studies have been conducted over a long period of time on various factors that determine the characteristics of storm surge, and most of relationships have been discovered. Because storm surge is complexly determined by various factors, it often show different results and draw different conclusions. For this reason, this study was conducted to understand the various characteristics of storm surge caused by changes in the forward speed of typhoons. This study was carried out with a numerical model, and the effect of forward speed could be analyzed by simplifying other factors as much as possible. When forward speed is increased, storm surges caused by typhoons tended to increase gradually. The storm surge showed a wide and gentle increase at a slow speed, but a narrow and steep one at a fast speed. In the case of the same forward speed, it was found that the storm surge was significantly influenced by the water depth of actual sea area. It was confirmed that the change in forward speed after passing Jeju Island did not significant affect on the storm surge in the south coast of Korea.
Safety Evaluation of the Combined Load for Offshore Wind Turbine Suction Foundation Installed on Sandy Soil
Authors: Park Jeong Seon
Published: November 2021

Offshore wind turbine (OWT) receive a combined vertical-horizontal- moment load by wind, waves, and the structure’s own weight. In this study, the bearing capacity for the combined load of the suction foundation of OWT installed on the sandy soil was calculated by finite element analysis. In addition, the stress state of the soil around the suction foundation was analyzed in detail under the condition that a combined load was applied. Based on the results of the analyses, new equations are proposed to calculate the horizontal and moment bearing capacities as well as to define the capacity envelopes under general combined loads.
Impact of Nanoparticle Size and Loading on Printability of Composite Inks for Direct Ink Writing
Authors: Li Yun , Flynn Aidan , Masternick Christopher , Kolanovic Brandon , Li Bin , Li Bo
Published: December 2024

Direct ink writing (DIW) using polymer‐particle composite inks is a new research area enabling a wide range of new functionalities. Despite extensive studies, there remains a need for a deeper understanding of how particle size and loading specifically influence printability, especially in the nano range. This work aims to systematically evaluate the effects of SiO2 nanoparticle size (26–847 nm) and loading on printability within a polydimethylsiloxane (PDMS) matrix. For the single‐layer printing process, which is influenced by the substrate properties, a 3D printing line analysis (3D‐PLA) is developed to monitor the top and side views of printed lines. It is found that line width varies with ink composition and substrate, while the line height decreases with solvent evaporation, indicating a strong confinement effect from the substrate. For multilayer structures, dual‐layer printing analysis (DLPA) is utilized to evaluate the printability. It is shown that DLPA is independent of the substrate and can be used to compare the printabilities from different inks. Both 3D‐PLA and DLPA can be correlated to the rheological behavior of the ink through ink rheology analysis (IRA). Finally, this research defined the design space for DIW by benchmarking the minimum and maximum particle loadings for printable composite inks.
Water Molecules Adsorption, Stability, and Optoelectronic Characteristics of Pb‐Free Hybrid Double Perovskites Cs2AgInX6 (X = Br, Cl) for Solar Cells Application: A DFT Analysis
Authors: Babaei Maryam , Ahmadi Vahid , Pakzad Moghadam Seyed Mojtaba
Published: December 2024

The development of halide double perovskites has received a lot of interest from many researchers due to solving the problem of poor stability and toxicity of lead‐based perovskites, which hinders the commercialization of perovskite solar cells. Therefore, in this work, the adsorption of water molecules, stability, optical, and electronic properties of double perovskites Cs2AgInX6 (X = Br, Cl) are investigated using Density Functional Theory (DFT) calculations. Theoretical analysis shows that these double perovskites are thermodynamically stable. The diffusion coefficient of water in layers of Cs2AgInBr6 and Cs2AgInCl6 is much lower than that of MAPbI3 according to means square displacement analysis, and also based on values of adsorption energy, the hydrophilicity of the proposed structure is lower than that of PbI2‐terminated and MAI‐terminated surfaces. These materials demonstrate better ductility and mechanical stability than their corresponding 3D perovskites. For Cs2AgInBr6 and Cs2AgInCl6, direct bandgap values are 1.49 and 3.14 eV, respectively, using hybrid Perdew‐Berke‐Ernzerhof + spin‐orbit‐coupling(PBE0+SOC) functional. Calculations of key solar cell parameters predict that Cs2AgInBr6 may achieve efficiencies competitive with MAPbI3 due to its high short‐circuit current, making it a promising stable, non‐toxic perovskite absorber material. This work provides fundamental insights that can guide further research on double perovskites for lead‐free, moisture‐resistant perovskite solar technologies.
Chromatin Topological Domains Associate With the Rapid Formation of Tandem Duplicates in Plants
Authors: Ma Ni , Li Xiaopeng , Ci Dong , Zeng Hai Yue , Zhang Congxiao , Xie Xiaodong , Zhong Caihong , Deng Xing Wang , Li Dawei , He Hang
Published: December 2024

In eukaryotes, chromatin is compacted within nuclei under the principle of compartmentalization. On top of that, condensin II establishes eukaryotic chromosome territories, while cohesin organizes the vertebrate genome by extruding chromatin loops and forming topologically associating domains (TADs). Thus far, the formation and roles of these chromatin structures in plants remain poorly understood. This study integrates Hi‐C data from diverse plant species, demonstrating that nuclear DNA content influences large‐scale chromosome conformation and affects the finer details of compartmental patterns. These contrasting compartmental patterns are distinguished by gene‐to‐gene loops and validated through cytological observations. Additionally, a novel chromatin domain type associated with tandem duplicate gene clusters is identified. These domains are independent of H3K27me3‐mediated chromatin compartmentalization and exhibit evolutionary conservation across species. Gene pairs within TAD‐like domains are younger and show higher levels of coexpression. These domains potentially promote the formation of tandem duplicates, a property appears unique to the Actinidia family. Overall, this study reveals functional chromatin domains in plants and provides evidence for the role of three‐dimensional chromatin architecture in gene regulation and genome evolution.
Super‐enhancer Activates Master Transcription Factor NR3C1 Expression and Promotes 5‐FU Resistance in Gastric Cancer
Authors: Yu Junxian , Chen Mengdi , Sang Qingqing , Li Fangyuan , Xu Zhuoqing , Yu Beiqin , He Changyu , Su Liping , Dai Wentao , Yan Chao , Zhu Zheng‐gang , Xia Jiazeng , Li Jianfang , Feng Haoran , Chen Yunqin , Li Yuan‐Yuan , Liu Bingya
Published: December 2024

Poor response to 5‐fluorouracil (5‐FU) remains an obstacle in the treatment of gastric cancer (GC). Super enhancers (SEs) are crucial for determining tumor cell survival under drug pressure. SE landscapes related to 5‐FU‐resistance are mapped to GC using chromatin immunoprecipitation‐sequencing (ChIP‐Seq). SiRNA transcription factors (TFs) screen determines master TF Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1) activated by SE. High NR3C1 expression driven by SE correlated with 5‐FU resistance in patient‐derived organoids (PDOs). Phase separation formed by NR3C1 is observed using fluorescence recovery after photobleaching (FRAP). NR3C1 protein and Mediator promoted SE‐related gene transcription via phase separation. SEs and NR3C1 co‐binding patterns are explored using Cleavage Under Targets and Tagmentation (CUT&Tag) sequencing. 5‐FU‐related genes driven by NR3C1 are identified using epigenetic reader inhibitor JQ1 and NR3C1 specific inhibitor Cort108297. NR3C1 knockdown increases 5‐FU sensitivity and alters the SE landscape through enhancer reprogramming, reducing downstream 5‐FU‐related target genes. JQ1 and Cort108297 both improve 5‐FU efficacy in PDOs and patient‐derived xenografts (PDXs) by destroying SEs or inhibiting NR3C1. In conclusion, SE‐driven NR3C1 promotes 5‐FU resistance in GC. SE destruction and NR3C1 inhibition lead to enhancer reconstruction and reduce 5‐FU‐related gene transcription, providing alternative therapeutic strategies for improving 5‐FU sensitivity.
A Modular Engineered DNA Nanodevice for Precise Profiling of Telomerase RNA Location and Activity
Authors: Zhang Shi‐Yi , Lv Jian , Zhou Ze‐Rui , Geng Peter X. , Li Da‐Wei , Qian Ruo‐Can , Ju Huangxian
Published: December 2024

Increased telomerase activity has been considered as a conspicuous sign of human cancers. The catalytic cores of telomerase involve a reverse transcriptase and the human telomerase RNA (hTR). However, current detection of telomerase is largely limited to its activity at the tissue and single‐cell levels. To reveal the precise distribution of subcellular hTR and telomerase activity, here a modular engineered DNA nanodevice (DNA‐ND) is designed capable of imaging hTR and telomerase activity in cytoplasm and nucleus, enabling colocalization analysis. DNA‐ND is a modular DNA complex comprising hTR and telomerase activity detection modules, which respectively sense intercellular hTR and telomerase activity via target‐sensitive allosteric transition of DNA switches, actuating orthogonal activation of fluorescence signals to achieve in situ co‐imaging of hTR and telomerase activity. By integrating DNA‐ND with specific localized signals, the DNA‐ND based precise profiling of colocalization of hTR and telomerase activity in different cell lines as well as their dynamic changes during pharmacological interventions is demonstrated. Notably, the results suggest that the locations of hTR and telomerase activity are not exactly overlapped, indicating the influence of intracellular environment on the binding of hTR to telomerase.
Spatially Selective Imaging in Color: What You See is What You Want
Authors: Chan John You En , Rajesh Akshaya , Lin Xiaoyu , Wang Hao , Wang Hongtao , Zhou Xiaoyan , Qiu Cheng‐Wei , Yang Joel K.W.
Published: December 2024

Spatially selective imaging (SSI) involves sampling a group of pixels from different positions on an encoded object to display a decoded image. Here, SSI is achieved by using off‐axis cylindrical Fresnel lens arrays to decode multiple images from an encoded print of structural color pixels. Each image is optically retrieved by separately placing different “keys” (arrays of lenses in different pseudorandom configurations) over the same encoded print, and then each image is digitally reconstructed for visualization. In addition, a detailed analysis is presented on the designed lenses and pixels, which are all fabricated by two‐photon polymerization lithography. Though Fresnel lenses are susceptible to chromatic aberrations, the results show that they can be used for imaging pixels that produce a wide range of colors at low numerical aperture (NA ≈0.2). The images have acceptable color contrast, corresponding to a simulated normalized modulation transfer function (MTF) of ≈0.6 averaged across wavelengths in the visible spectrum. This work can find applications in optical information security devices.
Direct Observation of Hybridization Between Co 3d and S 2p Electronic Orbits: Moderating Sulfur Covalency to Pre‐Activate Sulfur‐Redox in Lithium–Sulfur Batteries
Authors: Wang Di , Jia Yaozu , Jin Qi , Tian Fengying , Gao Qiong , Xu Xu , Lu Huiqing , Wu Lili , Ma Xinzhi , Zhang Xitian
Published: December 2024

Lithium–sulfur batteries (LSBs) offer high energy density and environmental benefits hampered by the shuttle effect related to sluggish redox reactions of long‐chain lithium polysulfides (LiPSs). However, the fashion modification of the d‐band center in separators is still ineffective, wherein the mechanism understanding always relies on theoretical calculations. This study visibly probed the evolution of the Co 3d‐band center during charge and discharge using advanced inverse photoemission spectroscopy/ultraviolet photoemission spectroscopy (IPES/UPS), which offers reliable evidence and are consistent well with theoretical calculations. This, coupled with in situ Raman and X‐ray diffraction (XRD) and electrochemical data, co‐evidences a novel pre‐activating S redox mechanism in LSBs: LiPSs desert/insert in C‐N matrixes within a series of Co@NCNT‐based separators. The insight of the S redox pre‐activation is discovered that the Co 3d‐band center downshifts to hybridized with S 2p orbitals in LiPSs, giving rise to a more pronounced S covalency and thus accelerating the conversion of LiPSs to S₈. Benefiting from these advantages, the optimized LSB possesses a minimal decay rate of 0.0058% after 200 cycles at a high discharge rate of 10 C. This study provides new insights into LSB mechanisms and supports conventional theoretical models of the d‐band center's impact on LSB performance.
Action Potential Firing Patterns Regulate Dopamine Release via Voltage‐Sensitive Dopamine D2 Autoreceptors in Mouse Striatum In Vivo
Authors: Sun Xiaoxuan , Yin Lili , Qiao Zhongjun , Younus Muhammad , Chen Guoqing , Wu Xi , Li Jie , Kang Xinjiang , Xu Huadong , Zhou Li , Li Yinglin , Gao Min , Du Xingyu , Hang Yuqi , Lin Zhaohan , Sun Liyuan , Wang Qinglong , Jiao Ruiying , Wang Lun , Hu Meiqin , Wang Yuan , Huang Rong , Li Yiman , Wu Qihui , Shang Shujiang , Guo Shu , Lei Qian , Shu Haifeng , Zheng Lianghong , Wang Shirong , Zhu Feipeng , Zuo Panli , Liu Bing , Wang Changhe , Zhang Quanfeng , Zhou Zhuan
Published: December 2024

Dopamine (DA) in the striatum is vital for motor and cognitive behaviors. Midbrain dopaminergic neurons generate both tonic and phasic action potential (AP) firing patterns in behavior mice. Besides AP numbers, whether and how different AP firing patterns per se modulate DA release remain largely unknown. Here by using in vivo and ex vivo models, it is shown that the AP frequency per se modulates DA release through the D2 receptor (D2R), which contributes up to 50% of total DA release. D2R has a voltage‐sensing site at D131 and can be deactivated in a frequency‐dependent manner by membrane depolarization. This voltage‐dependent D2R inhibition of DA release is mediated via the facilitation of voltage‐gated Ca2+ channels (VGCCs). Collectively, this work establishes a novel mechanism that APs per se modulate DA overflow by disinhibiting the voltage‐sensitive autoreceptor D2R and thus the facilitation of VGCCs, providing a pivotal pathway and insight into mammalian DA‐dependent functions in vivo.