bluuebunny/crossref_metadata_2025 huggingface dataset:
In the New Multimedia Era, “Post-90s” Counselors Do a Good Job of Adaptive Education Path Research for “Post-00s” Freshmen
Authors: Wang Ting
Published: August 2022

With the rapid development of network technology, all kinds of new media continue to emerge, and the “full-scale” zero-day difference of new media communication breaks through the scale of time and space. The era has come full circle. Today, “post-90s” counselors have gradually become the backbone of college counselors. At the same time, “post-00s” college students have gradually entered the campus and become the main force on campus. Counseling is a traditional profession. In the new era and new starting point, when the “post-00s” college freshmen begin to step into college campuses, how should the new counselors of the “post-90s” get along with them? The author believes that it is necessary to inherit the fine traditions, combine the characteristics of the times and the characteristics of new students, develop and innovate, pay close attention to the style of study, deepen the students, cultivate the backbone, work together at home and school, and study at all times so as to provide the source of living water and motivation for the growth of students. In the first month of college freshmen entering the school, they are still in the stage of exploration and adaptation, their study and living habits are not fixed, their learning methods have changed from supervised passive learning to conscious and active learning, and their lifestyles are also dominated by self-planning and self-management. After the “fresh period,” many freshmen show negative characteristics, such as weak self-discipline, laziness, and slack, and are full of confusion and contradictions. Guilt for not making progress. The decision at this stage is particularly important for freshmen to successfully complete their studies and discover their own value. Therefore, in view of the situation that freshmen cannot adapt to the new environment as soon as possible after being separated from the familiar environment, we should guide students to establish a positive learning and life attitude in the university from multiple angles, all-round and multiple ways, and integrate into the new life as soon as possible. This paper introduces the research status of ant colony algorithm and the existing path planning algorithms and space planning methods. Combined with the relevant knowledge of graph theory, the grid method is used to establish a space model.
Integrative Analyses of Biomarkers Associated with Endoplasmic Reticulum Stress in Ischemic Stroke
Authors: Zhang Xiaoting , Li Xi , Gu Jinyan , Guo Jingpei , Chen Jiayao , Zhang Ke , Liu Junfeng , Liu Jiani , Peng Chao , Liu Hanwei , Zhou Bin
Published: August 2022

Background. Neuronal apoptosis, which is the primary pathological transform of cerebral injury following ischemic stroke (IS), is considered to be induced by endoplasmic reticulum stress (ERS) by numerous reports. However, ERS biomarkers in IS have not been fully identified yet. Consequently, the present study is aimed at exploring potential blood biomarkers by investigating the molecular mechanisms of ERS promoting neuronal apoptosis following IS development. Methods. A comprehensive analysis was performed with two free-accessible whole-blood datasets (GSE16561 and GSE37587) from the Gene Expression Omnibus database. Genetic information from 107 IS and 24 healthy controls was employed to analyze the differentially expressed genes (DEGs). Genes related to ERS (ERS-DEGs) were identified from the analysis. Enrichment analyses were performed to explore the biofunction and correlated signal pathways of ERS-DEGs. Protein-protein interaction (PPI) network and immune correlation analyses were performed to identify the hub genes along with their correspondent expressions and functions, all of which contributed to incremental diagnostic values. Results. A total of 60 IS-related DEGs were identified, of which 27 genes were confirmed as ERS-DEGs. GO and KEGG enrichment analysis corroborated that upregulated ERS-DEGs were principally enriched in pathways related to immunity, including neutrophil activation and Th17 cell differentiation. Moreover, the GSEA and GSVA indicated that T cell-related signal pathways were the most considerably immune pathways for ERS-DEG enrichment. A total of 10 hub genes were filtered out via the PPI network analysis. Immune correlation analysis confirmed that the expression of hub genes is associated with immune cell infiltration. Conclusions. By integrating and analyzing the two gene expression data profiles, it can be inferred that ERS may be involved in the development of neuronal apoptosis following IS via immune homeostasis. The identified hub genes, which are associated with immune cell infiltration, may serve as potential biomarkers for relative diagnosis and therapy.
Construction of Prognostic Risk Model of Patients with Skin Cutaneous Melanoma Based on TCGA-SKCM Methylation Cohort
Authors: Yu Xiaoming , Cong Ping , Wei Wei , Zhou Yong , Bao Zhengqiang , Hou Huaying
Published: August 2022

Skin cutaneous melanoma (SKCM) is a common malignant skin cancer. Early diagnosis could effectively reduce SKCM patient’s mortality to a large extent. We managed to construct a model to examine the prognosis of SKCM patients. The methylation-related data and clinical data of The Cancer Gene Atlas- (TCGA-) SKCM were downloaded from TCGA database. After preprocessing the methylation data, 21,861 prognosis-related methylated sites potentially associated with prognosis were obtained using the univariate Cox regression analysis and multivariate Cox regression analysis. Afterward, unsupervised clustering was used to divide the patients into 4 clusters, and weighted correlation network analysis (WGCNA) was applied to construct coexpression modules. By overlapping the CpG sites between the clusters and turquoise model, a prognostic model was established by LASSO Cox regression and multivariate Cox regression. It was found that 9 methylated sites included cg01447831, cg14845689, cg20895058, cg06506470, cg09558315, cg06373660, cg17737409, cg21577036, and cg22337438. After constructing the prognostic model, the performance of the model was validated by survival analysis and receiver operating characteristic (ROC) curve, and the independence of the model was verified by univariate and multivariate regression. It was represented that the prognostic model was reliable, and riskscore could be used as an independent prognostic factor in SKCM patients. At last, we combined clinical data and patient’s riskscore to establish and testify the nomogram that could determine patient’s prognosis. The results found that the reliability of the nomogram was relatively good. All in all, we constructed a prognostic model that could determine the prognosis of SKCM patients and screened 9 key methylated sites through analyzing data in TCGA-SKCM dataset. Finally, a prognostic nomogram was established combined with clinical diagnosed information and riskscore. The results are significant for improving the prognosis of SKCM patients in the future.
Development Potential Evaluation for Land Resources of Forest Tourism Based on Fuzzy AHP Method
Authors: Cao Shizhen
Published: August 2022

With the development of modern economy and society, people have higher and higher requirements for spiritual needs request. The demand of traveling is a key growth point of the people’s spiritual needs. Forest tourism has become an important part of the forestry modernization. Its reasonable development can provide a site for urban residents’ leisure and health preservation, and help the revitalization of local villages and economic development. However, there are few studies on the evaluation methods of forest tourism land resources potential development around the world nowadays, and the planning and development of forest land resources are also lack of scientific guidance. The research work of this paper is carried out based on the realistic problems above, through analyzing the characteristics of the land resources of forest tourism, carding the main indicators of forest land resources development value, and fuzzy analytic hierarchy process (AHP) is studied to evaluate its development potential. The relevant conclusions can provide a theoretical guidance for the forest land resources development and planning, which will improve the development quality and effect of forest land resource.
Research on Security Anomaly Detection for Big Data Platforms Based on Quantum Optimization Clustering
Authors: Deng Lijuan , Wan Long , Guo Jian
Published: August 2022

Due to the explosive growth of data in the Internet, more and more applications are being deployed on Big Data platforms. However, as the scale of data continues to increase, the probability of anomalies in the platform is also increasing. However, traditional anomaly detection techniques cannot effectively handle the massive amount of historical data and can hardly meet the security requirements of big data platforms. In order to solve the above problems, this paper proposes a security anomaly detection method for big data platforms based on quantum optimization clustering. Firstly, a framework of big data platform anomaly detection system is designed based on distributed software architecture through Hadoop and Spark big data open source technology. The system achieves effective detection of network anomalies by collecting and analyzing big data platform server log data. Secondly, an offline anomaly detection algorithm based on quantum ant colony optimized affinity propagation clustering is designed for various anomalies mined from historical data. The bias parameters of the affinity propagation clustering are treated as individual ants to construct an ant colony, and the clustering accuracy is set as fitness. Finally, in order to improve the accuracy of the optimal path search of the ant colony, quantum bit encoding is applied to the ant colony position to refine the granularity of the individual ant colony position update. The experimental results show that the proposed method can effectively complete the anomaly clustering detection of massive data. With a reasonable threshold, the quantum ant colony–based affinity propagation clustering has high detection accuracy.
Cloud Computing Database and Travel Smart Platform Design Based on LSTM Algorithm
Authors: Chen Dongfeng
Published: August 2022

Information technology has played a key role in the development of the tourism planning service industry and has now become an important foundation for the survival and rapid development of the industry. In this context, due to the fast updating and popularization of information technology, it has greatly promoted the development of the tourism industry. In order to meet the current public demand for tourism information, this paper integrates cloud computing, VR technology, and big data analysis technology to build a smart platform for intelligent perception tourism information services. The system can obtain tourism information through mobile Internet terminals. Among them, the database of the smart tourism planning platform is the most important module. Aiming at the many difficulties in adapting data encryption in cloud storage applications, this article designs an adaptive CloudCrypt data encryption system based on cloud computing technology and proposes dynamic JavaScript dynamic analysis and automatic identification of data technology, through adaptive different cloud applications to obtain data encryption protection. CloudCrypt is suitable for typical cloud applications, such as mail and storage. The entry cost of the system is extremely low; it can fully guarantee the security of the tourism information platform database and can integrate wireless sensor networks into the tourism information platform. The network system composed of sensor nodes activates detection, calculation, and communication modules through wireless communication and has the advantages of low cost, low power consumption, and fast networking speed. In this paper, through the construction of integrated wireless sensor technology and cloud computing database, it is applied to the construction of a tourism smart platform, thereby promoting the development of smart travel technology.
[Retracted] Optimization and Application of Information Visualization Design Based on Image Symbol under the Guidance of Feature Integration Theory
Authors: Dong Qi
Published: August 2022

Increasingly, today’s businesses rely on data visualization to aid in the outcome that is directly linked to the bulk of their earnings. Due to the enormous volume, speed, and accuracy requirements of data management, database professionals are becoming increasingly necessary to aid in the effective visualization of data. Assuming the information to be depicted is free of ambiguity, most visualization approaches were developed. However, this is a rare occurrence. There has been a recent upsurge in visualizations that attempt to convey a sense of unpredictability. When it comes to visual optimization, we present a novel cognitive fuzzy logic‐based particle swarm optimization (CFLPSO) to optimize the data visualizations. Initially, the datasets are gathered as images as well as are denoised and enhanced by employing the bilateral three‐dimensional fairing median filter (B‐3D‐FMF) and contrast illuminate histogram equalization (CIHE), correspondingly. Principal component analysis (PCA) is utilized in the feature extraction stage to extract the features from the enhanced data. Then, the feature integration theory is applied to the extracted features, and also a fast rectangle‐packing algorithm is applied to the data visualization. And the proposed approach is employed for visual optimization. The performance of the proposed technique is examined and compared with other existing techniques to obtain the proposed technique with the greatest effectiveness of visual optimization. The findings are depicted by utilizing the Origin tool.
A Recommended Approach to Classical Literature and Art Exhibition Activities Oriented towards Interactive Modelling
Authors: He XiaoLing , Li Yifei
Published: August 2022

Chinese classical literature and art exhibition activities have a special role to play in improving the humanities of students. Introducing elements of classical literature into cultural activities can effectively complement the current humanities education in universities. To improve the efficiency and intelligence of classical literature and art exhibition activities, this paper proposes an interactive modelling-oriented method for recommending classical literature and art exhibition activities in response to the characteristics of existing art exhibition event management systems (AEEMS) in supporting process modelling and the interactive modelling needs of audiences. By using exhibition event segments as the recommended reference model, the process includes steps such as data preprocessing and calculating the matching degree and can recommend reasonable classical literature art exhibition events based on the art exhibition model under construction and the modelling needs of the audience. Experimental data are obtained by using a questionnaire survey method, and the experimental results show that it outperforms existing methods in terms of evaluation indicators such as accuracy, recall, and

F

1

, indicating the effectiveness of the proposed method.
[Retracted] Polyvinylpyrrolidone K‐30‐Based Crosslinked Fast Swelling Nanogels: An Impeccable Approach for Drug’s Solubility Improvement
Authors: Minhas Muhammad Usman , Khan Kifayat Ullah , Sarfraz Muhammad , Badshah Syed Faisal , Munir Abubakar , Barkat Kashif , Basit Abdul , Arafat Mosab
Published: August 2022

Poor solubility is a global issue of copious pharmaceutical industries as large number of drugs in development stage as well as already marketed products are poorly soluble which results in low dissolution and ultimately dosage increase. Current study is aimed at developing a polyvinylpyrrolidone‐ (PVP‐K30‐) based nanogel delivery system for solubility enhancement of poorly soluble drug olanzapine (OLP), as solubilization enhancement is the most noteworthy application of nanosystems. Crosslinking polymerization with subsequent condensation technique was used for the synthesis of nanogels, a highly responsive polymeric networks in drug’s solubility. Developed nanogels were characterized by percent entrapment efficiency, sol‐gel, percent swelling, percent drug loaded content (%DLC), percent porosity, stability, solubility, in vitro dissolution studies, FTIR, XRD, and SEM analysis. Furthermore, cytotoxicity study was conducted on rabbits to check the biocompatibility of the system. Particle size of nanogels was found with 178.99 ± 15.32 nm, and in vitro dissolution study exhibited that drug release properties were considerably enhanced as compared to the marketed formulation OLANZIA. The solubility studies indicated that solubility of OLP was noticeably improved up to 36.7‐fold in phosphate buffer of pH 6.8. In vivo cytotoxicity study indicated that prepared PVP‐K30‐based formulation was biocompatible. On the basis of results obtained, the developed PVP‐K30‐co‐poly (AMPS) nanogel delivery system is expected to be safe, effective, and cost‐effective for solubility improvement of poorly soluble drugs.
Xingnao Kaiqiao Acupuncture Combined with Butylphthalide Sodium Chloride Injection in the Treatment of Acute Cerebral Infarction and Its Effect on the Levels of Serum Malondialdehyde, Superoxide Dismutase, and Glutathione Peroxidase
Authors: Cui Junyi , Jia Handi
Published: August 2022

Objective. The aim of this study is to explore the therapeutic effect of Xingnao kaiqiao acupuncture combined with butylphthalide sodium chloride injection on acute cerebral infarction and its effect on the levels of serum malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH). Methods. 120 patients with acute cerebral infarction who were treated in our hospital from March 2020 to March 2022 and met the inclusion and exclusion criteria were divided into two groups. The control group was treated with sodium butylphthalide chloride injection, and the study group was treated with Xingnao kaiqiao acupuncture combined with sodium butylphthalide chloride injection. Results. After treatment, the levels of neurotransmitters, the TTP and RI and MDA in both groups decreased, and the Qmean, CBV values, and the levels of SOD and GSH increased, and the changes of index in the study group were more significant than those in the control group (

P
<
0.05

). After treatment, the NIHSS score and syndrome score of the two groups decreased, the MMSE score increased, the NIHSS score and syndrome score of the study group decreased more significantly than that of the control group, and MMSE score increased more significantly than that of the control group (

P
<
0.05

). In terms of clinical efficacy, the total effective rate of the study group was higher than that of the control group (

P
<
0.05

). Conclusion. Xingnao kaiqiao acupuncture combined with butylphthalide sodium chloride injection is effective in patients with acute cerebral infarction. It can improve the level of neurotransmitters and cerebral blood flow perfusion and inhibit the abnormal expression of MDA, SOD, and GSH.
The Overall Survival and Safety of Men with Metastatic Hormone-Sensitive Prostate Cancer Treated with Combination Therapy of Novel Androgen Receptor Antagonists and Androgen-Deprivation Therapy: A Systematic Review and Meta-Analysis
Authors: Wu Xupeng , Han Haisong , Zhang Chao , Song Wei
Published: August 2022

Background. Several novel androgen receptor antagonists have been introduced into the treatment of metastatic hormone-sensitive prostate cancer (mHSPC). We conducted a meta-analysis to evaluate the survival and safety of the combination therapy of novel androgen receptor antagonist and androgen-deprivation therapy (ADT) in patients with mHSPC. Methods. Electronic databases were searched for randomized controlled trials (RCTs) of ADT combined with novel androgen receptor antagonists compared with ADT alone in men with mHSPC. Revman 5.4 and STATA 14.0 were used to performed the meta-analysis, and hazard ratio (HR) and odds ratio (OR) with 95% confidence intervals (CIs) were used as the measurement indicators of outcome variables. Results. Six RCTs were eventually identified for meta-analysis. Compared with ADT alone, the combination therapy of novel androgen receptor antagonists and ADT can significantly improve the overall survival (OS) and progression-free survival (PFS), as the pooled HR were 0.66, 95%CI (0.60, 0.72),

P
<
0.00001

and 0.43, 95%CI (0.34, 0.54),

P
<
0.00001

, respectively, despite increasing the risk of any serious adverse events (OR: 1.18, 95%CI (1.04, 1.33),

P
=
0.008

). Discussion. This study showed that compared with ADT alone, the combination therapy of novel androgen receptor antagonists and ADT can significantly improve the survival status of mHSPC patients, while it increases the risk of serious adverse events.
Insulator Leakage Current Prediction Using Hybrid of Particle Swarm Optimization and Gene Algorithm-Based Neural Network and Surface Spark Discharge Data
Authors: Nguyen Thanh Phuong , Cho Ming-Yuan
Published: August 2022

This study proposes a new superior hybrid algorithm, which is the particle swarm optimization (PSO) and gene algorithm (GA)-based neural network to predict the leakage current of insulators. The developed algorithm was utilized for the online monitoring systems, which were completely installed on the 69 kV and 161 kV transmission towers in Taiwan. This hybrid algorithm utilizes the local meteorological data as input parameters combined with the extracted enhanced data: the percentage of spark discharge areas and the brightness change in the image of the discharge phenomenon. These data with a high correlation with the leakage current are utilized as input vectors to improve the accuracy and effectiveness of the developed hybrid model. The performance of the developed algorithm is compared with a traditional PSO-based neural network and backpropagation neural network (BPNN) to evaluate and analyze. The comparative simulation results prove the effectiveness of the combination of hybrid PSO-GA-based neural network and surface discharge data, which achieved a maximum improvement of 38.54% MSE, 10.62% MAPE, and 3.41% R square for 161 kV data and 39.28% MSE, 12.62% MAPE, and 1.61% R square for 69 kV data. Moreover, the data with enhanced inputs outperform the traditional data in most benchmark factors, improving the accuracy and effectiveness in defining the deteriorative insulators. The developed methodology with a noticeable improvement was utilized in the online monitoring system to reduce the operational and maintenance cost of transmission lines in Taiwan Power Company.
Nutritional Value and In Vitro Volatile Fatty Acid Production of Forage Grasses Cultivated Using Farmyard Manure and Desmodium intortum Intercropping in the Upper Blue Nile Basin, Ethiopia
Authors: Walie Misganaw , Tegegne Firew , Mekuriaw Yeshambel , Tsunekawa Atsushi , Kobayashi Nobuyuki , Ichinohe Toshiyoshi , Haregeweyn Nigussie , Tassew Asaminew , Mekuriaw Shigdaf , Masunaga Tsugiyuki , Tsubo Mitsuru , Adgo Enyew , Meshesha Derege Tsegaye
Published: August 2022

Integrating farmyard manure (FYM) and legume intercropping improves soil chemical and microbial properties, thereby increasing forage productivity and nutritional value. The purpose of this study was to evaluate how fertilizer treatments affected the chemical composition, in vitro gas production and organic matter digestibility (IVOMD), and volatile fatty acid production (VFA) of Napier and desho grasses in the upper Blue Nile basin of Ethiopia. Apart from ether extract content, the chemical composition of the fertilizer treatments in the Aba Gerima watershed did not differ significantly, whereas significant differences were observed in acid detergent fiber and crude protein contents at the Guder watershed. In both watersheds, Napier grass had significantly higher crude protein levels than desho grass. In Aba Gerima, ash content was significantly higher in 2018 than in 2019, but not in Guder. For Napier and desho grasses, there were an increment in IVOMD (6.7 vs 4.7%), metabolizable energy (5.5 vs 4.5%), and VFA production (23.1 vs 3.0%) in the Desmodium intortum plus FYM treatment than in the control in Aba Gerima. In Guder, however, IVOMD (13.7 vs 4.6%), metabolizable energy (13.3 vs 3.3%), and VFA production (11.2 vs 5.6%) increased in the same treatment for Napier and desho grasses than in the control. This study suggests that the Desmodium intortum plus FYM improves the nutritional value, IVOMD, and VFA production of Napier and desho grasses in dryland areas of the upper Blue Nile basin, facilitating their growth as alternative livestock feed for better production in these areas.
Full Delay Logistic Population Model with Sustainable Harvesting
Authors: Anokye Martin , Donkoh Elvis Kobina , Ofori Michael Fosu , Adom-Konadu Agnes
Published: August 2022

The paper studies the dynamics of a full delay-logistic population model incorporated with a proportionate harvesting function. The study discusses the stability of the model in comparison with the well-known Hutchinson logistic growth equation with harvesting function using the rate of harvesting as a bifurcation parameter to determine sustainable harvesting rate even at a bigger time delay of

τ
=
3.00

. In all cases, the Hutchinson equation with harvesting was forced to converge to equilibrium using an additional and a different time delay parameter, a deficiency previous researchers have failed to address when the Hutchinson model is used for this purpose. The population fluctuations are catered for with this model making the estimated maximum sustainable growth and harvest reflect realities as this model drastically reduces time-delay associated oscillations compared to the well-known Hutchinson delayed logistic models. The numerical simulations were be done using the MatLab Software.
A Clinical Radiomics Nomogram Was Developed by Integrating Radiomics Signatures and Clinical Variables to Distinguish High-Grade ccRCC from Type 2 pRCC
Authors: Gao Yankun , Zhao Xiaoying , Wang Xia , Zhu Chao , Li Cuiping , Li Jianying , Wu Xingwang
Published: August 2022

Purpose. A nomogram was constructed by combining clinical factors and a CT-based radiomics signature to discriminate between high-grade clear cell renal cell carcinoma (ccRCC) and type 2 papillary renal cell carcinoma (pRCC). Methods. A total of 142 patients with 71 in high-grade ccRCC and seventy-one in type 2 pRCC were enrolled and split into a training cohort (n = 98) and a testing cohort (n = 44). A clinical factor model containing patient demographics and CT imaging characteristics was designed. By extracting the radiomics features from the precontrast phase, corticomedullary phase (CMP), and nephrographic phase (NP) CT images, a radiomics signature was established, and a Rad-score was computed. By combining the Rad-score and significant clinical factors using multivariate logistic regression analysis, a clinical radiomics nomogram was subsequently developed. The diagnostic performance of these three models was evaluated by using data from both the training and testing groups using a receiver operating characteristic (ROC) curve analysis. Results. The radiomics signature contained eight validated features from the CT images. The relative enhancement value of CMP (REV1) was an independent risk factor in the clinical factor model. The area under the curve (AUC) value of the clinical radiomics nomogram was 0.974 and 0.952 in the training and testing cohorts, respectively. In the training cohort, the decision curves of the nomogram demonstrated an added overall net advantage compared to the clinical factor model. Conclusion. A noninvasive prediction tool termed radiomics nomogram, combining clinical criteria and the radiomics signature, may accurately predict high-grade ccRCC and type 2 pRCC before surgery. It also has some importance in assisting clinicians in determining future treatment strategies.
Xiaotan Sanjie Decoction Inhibits Gastric Cancer Cell Proliferation, Migration, and Invasion through lncRNA‐ATB and miR‐200A
Authors: Zhou Zhe , Chen Jiabin , Li Mingqian , Cao Liping , Chen Miao , Zhang Qingqian , Yu Zhihong , Chai Kequn
Published: August 2022

This study is aimed at exploring whether Xiaotan Sanjie decoction (XTSJ) inhibits gastric cancer (GC) proliferation and metastasis by regulating lncRNA‐ATB expression. qRT‐PCR and Western blot were used to analyze lncRNA‐ATB and downstream‐regulated genes/proteins in human GC cells. CCK8, Edu, and flow cytometry assays were used to detect the inhibitory effect of XTSJ on cell proliferation and apoptosis. Moreover, transwell and wound healing assays were used to detect the inhibitory effect of XTSJ on migration and invasion. qRT‐PCR and Western blot were used to detect regulated genes and proteins levels. The HGC‐27 cell line was used for follow‐up analysis due to the high level of lncRNA‐ATB and cell characteristics. XTSJ inhibited the proliferation and metastasis of HGC‐27 in a dose‐dependent manner. Further research found that XTSJ downregulated lncRNA‐ATB, Vimentin, and N‐cadherin, while it upregulated miR‐200a and E‐cadherin in a dose‐dependent manner. XTSJ also upregulated Caspase 3, Caspase 9, Bax, and downregulated Bcl‐2. Furthermore, XTSJ inhibited tumor growth in vivo and downregulated EMT signaling pathways. These results indicate that XTSJ may affect EMT and Bcl‐2 signaling pathways by regulating lncRNA‐ATB and miR‐200a, thus inhibiting proliferation, migration, and invasion of HGC‐27 cells. Therefore, XTSJ may be an effective treatment for the high levels of lncRNA‐ATB in GC.
[Retracted] Cultural Connotation and Image Dissemination of Ancient Villages under the Environment of Ecological Civilization: A Case Study of Huizhou Ancient Villages
Authors: Zhao Mingming , Liang Jun , Lu Shanquan
Published: August 2022

Ecological civilization refers to the sum of the material production and consumption mode, social organization and management system, values and ethics, and resource development and environmental influence mode between man and nature created in the practice of transforming nature, adapting to nature, conserving nature, and savoring nature. The construction of ecological civilization is an important part of the realization of the new rural construction goal of “production development, well‐off life, civilized village customs, clean village appearance, and democratic management.” With the comprehensive promotion of the construction of a new socialist countryside in China, the ancient villages, as the source foundation of Chinese national culture and the real record of historical information, have become an urgent and severe topic for the current village renovation and protection. This article studies the architectural modeling, village layout, space, color application, and other aspects of ancient Huizhou village architecture, appreciates some elements of form aesthetics, and explores its rich content in modern society, cultural background, and economic conditions. At the same time, starting from the architectural characteristics of ancient Huizhou villages, integrate and understand the characteristics of village layout, architectural shape, and space color application in Huizhou traditional ancient village architecture, and analyze the harmonious beauty, overall beauty, nature, and coordination covered in Huizhou traditional ancient village architecture beauty and other beautiful features. To study the architectural shape, village layout, space, and color application in Huizhou's ancient village buildings, appreciate some elements of morphological aesthetics, and explore its rich content contained in modern society, cultural background, and economic conditions. At the same time, starting from the architectural characteristics of Huizhou ancient villages, we can integrate and understand the characteristics of village layout, architectural shape, and spatial color application in Huizhou traditional ancient villages, and analyze the characteristics of harmony, overall beauty, nature, and coordinated beauty covered in the architecture of Huizhou traditional ancient villages. This study is of great practical significance to promote the comprehensive improvement and protection of historical buildings, traditional residential communities, historical features, and surrounding ecological environment in ancient villages, and to realize the unity of ecology and civilization, efficiency and energy saving, healthy and sustainable development of ancient villages.
Cervicofacial Cellulitis due to Staphylococcus aureus with Jugular Vein Thrombosis and Multiple Septic Pulmonary Embolism: A Lemierre-Like Syndrome
Authors: Niang Ibrahima , Diouf Latyr Junior , Diop Papa Abdou , Thioub Daouda , Sarr Alassane , Diouf Khadidiatou Ndiaye , Akpo Geraud Lera , Diop Abdoulaye Dione , Ba Sokhna
Published: August 2022

This is the case of a 28-year-old male patient with no particular pathological history who presented with an inflammatory swelling of the right cheek with pus in an infectious context. Cervicofacial CT with contrast injection allowed the diagnosis of a right cervicofacial cellulitis, associated with a jugular venous thrombosis extending to the superior vena cava. It also revealed septic pulmonary metastases in the form of multiple excavated pulmonary nodules. The analysis of the pus sample allowed the isolation of Staphylococcus aureus as the causative germ. This led to the diagnosis of a Lemierre-like syndrome, which is a variant of the Lemierre syndrome. Despite appropriate antibiotic treatment and anticoagulation, the patient died after 16 days of hospitalization.
Sustainable Portfolio Optimization Model Using PROMETHEE Ranking: A Case Study of Palm Oil Buyer Companies
Authors: Ahmadi Seyedeh Asra , Peivandizadeh Ali
Published: August 2022

Sustainability is one of the main concerns of decision makers, factories, and retailers. This importance increases when the organization needs to define, implement, and manage a sustainable portfolio to succeed in today’s environment of change and uncertainty. Therefore, this study examines the portfolio of palm producers from 2010 to 2020. The proposed optimization model is based on the classic mean‐variance approach and companies ranked using the PROMETHEE method. Our findings indicate that the effects of this asset allocation change in favour of high‐score sustainability investments significantly influence risk‐adjusted returns of portfolios. According to the finding, sustainable portfolios perform better than conventional ones. The findings could be useful to private and institutional investors and fund managers in constructing and managing their portfolios. The efficient frontier of the best 50% portfolio shows a higher risk for a higher return. This could explain that a higher sustainability score in different criteria leads to more optimal portfolios in terms of risk and return. Intended contributions include considering sustainability, minimizing risk, and portfolio management simultaneously.
A Rare Case of Orthostasis, Dizziness, and Non-O1, Non-O139 Vibrio cholerae Infection in a Lung Transplant Recipient
Authors: Olson Michael T. , Walia Tejus , Chandrashekaran Satish , Biswas Roy Sreeja , Arjuna Ashwini
Published: August 2022

Non-O1, non-O139 Vibrio cholerae are rare strains that are generally nonpathogenic in immunocompetent hosts. However, this pathogen has been shown to cause gastroenteritis, wound infections, or bacteremia in immunocompromised patients and is associated with significant mortality in these hosts. Herein, we describe a case of hemorrhagic enterocolitis in a lung transplant recipient with an atypical presentation of non-O1, non-O139 V. cholerae and ongoing orthostasis. The patient reported recent seafood consumption and was managed appropriately with antibiotic therapy before necessitating esophagogastroduodenoscopy (EGD) for further objective testing.
Inhibition of Delayed Cerebral Ischemia by Magnesium Is Insufficient for Subarachnoid Hemorrhage Patients: A Network Meta-Analysis
Authors: Ba Xiao-Hong , Wang Xiao-Di , Dai Yong-Yi
Published: August 2022

Objective. After subarachnoid hemorrhage, magnesium could reduce the incidence of delayed cerebral ischemia; however, it is still controversial. This study updated the results of recently published magnesium-related studies and conducted an exploratory analysis of the impact of application strategies and intervention factors on the results. Methods. Public databases were searched from the date of their inception to May 10, 2021. Randomized controlled trials on magnesium agent-related regimens for subarachnoid hemorrhage patients were included. Results. In total, 28 articles were included in the meta-analysis. For delayed cerebral ischemia, magnesium-related interventions significantly reduced the risk of delayed cerebral ischemia compared with nonmagnesium interventions (odds ratios: 0.40; 95% confidence interval: 0.28–0.56;p<0.01). For cerebral vasospasm, a random effects model showed that magnesium significantly reduced the risk of cerebral vasospasm (odds ratios: 0.46; 95% confidence interval: 0.33–0.63;p<0.01). In the subgroup analysis, intracranial magnesium (odds ratios: 6.67; 95% confidence interval: 1.14–38.83;p=0.03) and magnesium plus hydrogen (odds ratios: 10; 95% confidence interval: 1.59–62.73;p=0.01) produced significant results in improving the good recovery rate compared to the control. In the network meta-analysis, magnesium plus nimodipine and simvastatin even showed an effective trend in death/persistent vegetative status improvement. Conclusion. This study supports the beneficial effect of magnesium in reducing the risk of delayed cerebral ischemia. Based on a single randomized controlled trial, immediate intracranial magnesium therapy with intravenous hydrogen after subarachnoid hemorrhage can increase the good recovery rate. Therefore, more high-quality studies are needed to confirm this finding.
Balloon Eustachian Tuboplasty and Grommet Insertion: A Combined Surgical Treatment for Chronic Suppurative Otitis Media with Eustachian Tube Dysfunction
Authors: Lu ShuXuan , Xu Jin , Lu HongYi , Chi WanLei
Published: August 2022

Objectives. This study aims to evaluate the effectiveness of Balloon Eustachian tuboplasty (BET) and grommet insertion in patients having chronic suppurative otitis media combined with eustachian tube dysfunction (CSOM-ETD). Methods. We evaluated the data of CSOM-ETD patients (n = 96) from January 2019 to January 2021, who were divided into the following groups: 48 cases underwent BET (BET group) and 48 cases underwent BET plus Grommet insertion (BET + Grommet group). The air-bone gap (ABG), Eustachian Tube Dysfunction Questionnaire (ETDQ‐7) score, Eustachian tube inflammation scale, Chronic Otitis Media Outcome Test 15 (COMOT-15), Valsalva maneuver, and patient satisfaction were evaluated after surgery. Results. The postoperative ABG in the BET + Grommet group was better than that in the BET. In addition, the ABG was improved obviously in the BET + Grommet group at 6 and 12 months after the corresponding surgery. Moreover, the Eustachian tube inflammation scale, ETDQ-7, and COMOT-15 scores were reduced after the treatment with the combination of BET and Grommet insertion at 6 and 12 months. The postoperative ETDQ-7 score, Eustachian tube inflammation scale, and COMOT-15 score were lower in the BET + Grommet group than that in the BET group. The percentage of patients who could perform a positive Valsalva maneuver was significantly higher in the BET + Grommet group than that in the BET group at 6 months and 12 months after surgery with increased patient satisfaction. Conclusion. Our results demonstrate that BET plus Grommet insertion showed better treatment efficacy for patients with CSOM-ETD than BET alone via improving the Eustachian tube function hearing outcome and quality of life with less Eustachian tube inflammation.
Competitive Risk Model for Specific Mortality Prediction in Patients with Bladder Cancer: A Population-Based Cohort Study with Machine Learning
Authors: Su Hao , Xue Xiaoqiang , Wang Yutao , Lu Yi , Ma Chengquan , Ji Zhigang , Su Xiaozhe
Published: August 2022

Background. Noncancer death accounts for a high proportion of all patients with bladder cancer, while these patients are often excluded from the survival analysis, which increases the selection bias of the study subjects in the prediction model. Methods. Clinicopathological information of bladder cancer patients was retrieved from the Surveillance, Epidemiology, and End Results (SEER) database, and the patients were categorized at random into the training and validation cohorts. The random forest method was used to calculate the importance of clinical variables in the training cohort. Multivariate and univariate analyses were undertaken to assess the risk indicators, and the prediction nomogram based on the competitive risk model was constructed. The model’s performance was evaluated utilizing the calibration curve, consistency index (C index), and the area under the receiver operator characteristic curve (AUC). Results. In total, we enrolled 39285 bladder cancer patients in the study (27500 patients were allotted to the training cohort, whereas 11785 were allotted to the validation cohort). A competitive risk model was constructed to predict bladder cancer-specific mortality. The overall C index of patients in the training cohort was 0.876, and the AUC values were 0.891, 0.871, and 0.853, correspondingly, for 1-, 3-, and 5-year cancer-specific mortality. On the other hand, the overall C index of patients in the validation cohort was 0.877, and the AUC values were 0.894, 0.870, and 0.847 for 1-, 3-, and 5-year correspondingly, suggesting a remarkable predictive performance of the model. Conclusions. The competitive risk model proved to be of great accuracy and reliability and could help clinical decision-makers improve their management and approaches for managing bladder cancer patients.
Sotorasib Shows Intracranial Activity in Patients with KRAS G12C-Mutated Adenocarcinoma of the Lung and Untreated Active Brain Metastases
Authors: Koster Kira-Lee , Appenzeller Christina , Lauber Arno , Früh Martin , Schmid Sabine
Published: August 2022

Treatment with sotorasib has shown intracranial complete responses and continued intracranial stabilization in KRAS G12C-mutated non-small-cell lung carcinoma (NSCLC) patients with previously treated, stable brain metastases in a post hoc analysis of the ongoing CodeBreaK 100 trial. We present the case of a patient with KRAS G12C-mutant adenocarcinoma of the lung with active untreated brain metastases with a nearly complete intracranial response only 6 weeks after start of sotorasib illustrating the benefit of sotorasib in patients with active, previously untreated brain metastases in KRAS G12C-mutated NSCLC.
Apoptosis-Decellularized Peripheral Nerve Scaffold Allows Regeneration across Nerve Gap
Authors: Wachs Rebecca A. , Wellman Steven M. , Porvasnik Stacy L. , Lakes Emily H. , Cornelison R. Chase , Song Young Hye , Allen Kyle D. , Schmidt Christine E.
Published: August 2022

Peripheral nerve injury results in loss of motor and sensory function distal to the nerve injury and is often permanent in nerve gaps longer than 5 cm. Autologous nerve grafts (nerve autografts) utilize patients’ own nerve tissue from another part of their body to repair the defect and are the gold standard in care. However, there is a limited autologous tissue supply, size mismatch between donor nerve and injured nerve, and morbidity at the site of nerve donation. Decellularized cadaveric nerve tissue alleviates some of these limitations and has demonstrated success clinically. We previously developed an alternative apoptosis-assisted decellularization process for nerve tissue. This new process may result in an ideal scaffold for peripheral nerve regeneration by gently removing cells and antigens while preserving delicate topographical cues. In addition, the apoptosis-assisted process requires less active processing time and is inexpensive. This study examines the utility of apoptosis-decellularized peripheral nerve scaffolds compared to detergent-decellularized peripheral nerve scaffolds and isograft controls in a rat nerve gap model. Results indicate that, at 8 weeks post-injury, apoptosis-decellularized peripheral nerve scaffolds perform similarly to detergent-decellularized and isograft controls in both functional (muscle weight recovery, gait analysis) and histological measures (neurofilament staining, macrophage infiltration). These new apoptosis-decellularized scaffolds hold great promise to provide a less expensive scaffold for nerve injury repair, with the potential to improve nerve regeneration and functional outcomes compared to current detergent-decellularized scaffolds.
Long-Term Noninvasive Ventilation in Chronic Obstructive Pulmonary Disease: Association between Clinical Phenotypes and Survival
Authors: Janssens Jean-Paul , Cantero Chloé , Pasquina Patrick , Jaksic Cyril , Adler Dan , Uldry Christophe , Egger Bernard , Prella Maura , Younossian Alain Bigin , Rabec Claudio , Soccal Gasche Paola M. , Pépin Jean-Louis ,   on behalf of all the investigators of the Geneva Lake Study
Published: August 2022

Background: Long-term noninvasive ventilation (LTNIV) is widely used in patients with chronic hypercapnic respiratory failure (CHRF) related to COPD. Prognosis of these patients is however poor and heterogenous. Research Question: In COPD patients under LTNIV for CHRF, is it possible to identify specific phenotypes which are predictive of probability of pursuing NIV and survival? Study Design and Methods: A latent class analysis was performed in a COPD population under LTNIV included in a comprehensive database of patients in the Geneva Lake area, to determine clinically relevant phenotypes. The observation period of this subgroup of COPD was extended to allow assessment of survival and/or pursuit of NIV for at least 2 years after inclusion. A logistic regression was conducted to generate an equation accurately attributing an individual patient to a defined phenotype. The identified phenotypes were compared on a series of relevant variables, as well as for probability of pursuing NIV or survival. A competitive risk analysis allowed to distinguish death from other causes of cessation of NIV. Results: Two phenotypes were identified: a “respiratory COPD” profile with very severe airway obstruction, a low or normal body mass index, and a low prevalence of comorbidities and a “systemic COPD” profile of obese COPDs with moderate airway obstruction and a high rate of cardiovascular and metabolic comorbidities. The logistic regression correctly classified 95.7% of patients studied. Probability of pursuing NIV and survival were significantly related to these phenotypes, with a poorer prognosis for “respiratory COPD.” Probability of death 5 years after implementing NIV was 22.3% (95% CI: 15.4–32.2) for “systemic COPD” versus 47.2% (37.4–59.6) for “respiratory COPD” (p = 0.001). Conclusion: The two distinct phenotypes of COPD under LTNIV for CHRF identified appear to be strongly related to prognosis and require further validation in other cohort studies.
Dactylitis and Ungual Tuberculosis: An Atypical Presentation of the Disease
Authors: Lemos Thayane , Horwacz Núria , Baka Jessica , Mourão Alice , Gripp Alexandre , Pires Marianna T.F. , Ceccarelli Miguel A.
Published: August 2022

Introduction: Tuberculosis is a common infection caused by Mycobacterium tuberculosis in developing countries. Among the extrapulmonary forms of tuberculosis, cutaneous tuberculosis is rare, and even dermatologists are less familiar with its ungual manifestations. Case Presentation: We present an exuberant case of ungual tuberculosis in a patient with no personal or family history of immunosuppression, which is the first manifestation of the disseminated form of the disease. Conclusion: In our patient, the initial manifestation was related to the nail, probably originating from the progression of bone TB focus, which further progressed with respiratory symptoms and involvement of other organs. We believe this is the first case in which the ungual presentation allowed the diagnosis of disseminated tuberculosis.