bluuebunny/crossref_metadata_2025 huggingface dataset:
Youth Travel in the Pandemic of COVID-19
Authors: Д.С. Теплова,
Published: December 2022

COVID-19 оказал негативное влияние на весь мир, в том числе на молодежный туризм. Ограничение перемещений, снижение доходов молодых людей в совокупности со страхами и  стрессами угрожают развитию молодежного туризма и, соответственно, возможностям социально-экономического развития туристских дестинаций. Именно поэтому важно своевременно изучить влияние пандемии на потребительское поведение молодежи для немедленного реагирования на изменения. Представлен обзор мировых исследований влияния COVID-19 на молодежь и рекомендации ЮНВТО по восстановлению молодежного туризма.

COVID-19 has had a negative impact on the whole world, including youth travel. Restrictions on movement, a decrease in the income of young people, combined with fears and stresses, put a risk the development of youth tourism and, accordingly, the possibilities for the socio-economic development of tourist destinations. That is why it is important to timely study the impact of the pandemic on the  consumer behavior of  young people in  order to  immediately respond to  changes. The article provides an overview of global reseaches on the impact of COVID-19 on youth and UNWTO youth travel recovery recommendations.
Sustainable Development – an Evolution Perspective for the Mankind?
Authors: С.Ю. Кашкин,
Published: December 2022

Рассматриваются основные тенденции развития права на этапе цифровой трансформации  – от  киберправа через интеграционное право, сетевое право, платформенное право и в направлении к концепции устойчивого развития, на которой формируется право устойчивого развития. Обосновываются основные тенденции правового развития современности, объясняются причины и  следствия вызывающих эволюцию права общественных явлений с  акцентом на формирование права устойчивого развития, его черт и  особенностей. Используются методы сравнительного правоведения, сравнительного интеграционного права, методология сетевого, платформенного и экосистемного права, а также права устойчивого развития. Делаются выводы и рекомендации для исследователей и практиков.

The article discusses the main trends in the development of modern law at the stage of digital transformation – from cyber law, through integration law, network law, platform law and towards the concept of sustainable development, on which the law of sustainable development is formed. The main trends in the legal development of modernity are substantiated, the causes and consequences of social phenomena causing the evolution of law are explained with an emphasis on the formation of the law of sustainable development, its features and characteristics. The methods of comparative law, integration comparative law, the methodology of network, platform and ecosystem law, as well as the law of sustainable development are used. Conclusions and  recommendations for researchers and  practitioners are made.
From the History of Genesis and Development of Russian Legal Science in the 18th Century
Authors: В.И. Кирмикчи,
Published: December 2022

Освещаются исторические особенности и сложный характер становления русского правоведения и его дальнейшего развития в XVIII веке. Показана роль императора Петра I и его сподвижников, М.В. Ломоносова в необходимости изучения юридической науки. Исследуются основные идеи И.А. Третьяковского, которые относятся к праву, экономике и этике.

The article highlights the historical features and complex nature of the formation of Russian jurisprudence and its future development in the 18th century. The role of Emperor Peter I and his associates in the need to study legal science is shown. The main ideas of I.A. Tretyakovskii, which relate to law, economics and ethics are investigated.
Um paradoxo civilizatório: a pandemia como desafio ao ensino e trabalho na saúde e como afirmação das vidas
Authors: Ferla Alcindo Antônio , Merhy Emerson Elias , Baptista Gabriel Calazans , Schweickardt Júlio Cesar , Nicoli Maria Augusta , Pereira Maria das Graças Alves , Ferreira da Silva Maria Rocineide , Valladares Miguel Ángel Orozco , Ceccim Ricardo Burg , Martino Ardigò , Franco Túlio Batista
Published: December 2022

Editorial
How Meaning of Life Correlates with Emptiness Syndrome of Minangkabau Elderly Women
Authors: Arya Fendha Ibnu Shina
Published: December 2022

The matrilineal culture in Minangkabau, West Sumatra, is a culture that is thick with emancipation values and the teachings of feminism. The matrilineal kinship system contains the importance of gender equality and justice, both philosophically and in terms of implementation. However, in reality, there has been a shift in the pattern of social responsibility towards women's parents who should have the position of bundo kanduang. The change in the way of social responsibility is marked by the number of parents being put into nursing homes. Psychological conditions related to emptiness syndrome and self-significance in elderly women need to be analyzed. This study involved 40 elderly women who live in social institutions in West Sumatra. This study concluded that there was a significant negative relationship (P value = 0.011) between the meaning of life and emptiness syndrome, which was a -0.396 Pearson correlation.
Student Career Decision Making: Self-Efficacy and Future Orientation
Authors: Alif Muarifah  , Nurliyana Titah
Published: December 2022

This study aims to empirically examine the effect of career decision-making on self-efficacy and future orientation. This research method uses a quantitative using cluster random sampling technique. The number of subjects used amounted to 177 SMK students. The data analysis technique used multiple linear regression. The results of hypothesis testing together obtained an R-value of 0.693 with a significance value of 0.000 (p < 0.01). It is concluded that the hypothesis is accepted, that is, there is a significant influence between self-efficacy and future orientation on career decision-making. This means that a higher level of self-efficacy and future orientation strongly influence career decision-making. The first minor hypothesis test obtained a t-value of 4.834 with a significance level of 0.000 (p <0.01). It is concluded that the hypothesis is accepted; self-efficacy has a very significant positive effect on career decision-making. The results of the second minor analysis obtained a t-value of 2.832 with a significance level of 0.005 (p <0.05). It is concluded that the hypothesis is accepted; future orientation has a very significant positive effect on career decision-making.
THE METHODOLOGY FOR EVALUATING THE FUNCTIONAL STABILITY OF THE PROTECTION SYSTEM OF SPECIAL NETWORKS
Authors: Tolupa Sergii , Laptіev Sergii
Published: December 2022

Information systems function under the influence of external and internal destabilizing factors. Under negative influence, system modules may fail. However, the systems must function offline for a specified time. Such a condition of functioning can be fulfilled by ensuring the property of functional stability. The property of functional stability was introduced due to the observation of the behavior of biological systems, organisms with the inherent property to fulfill given goals with physical damage due to biological redundancy: sets of sense organs, physiological analyzers, nerve fibers, the configuration of the brain as a control and information processing system, as well as symmetry body The main feature of functionally stable systems is their ability to degrade at the structural level until the system completely fails, that is, to exclude defective elements from the structure, to rebuild the structure, to adjust the system parameters. adapt to new operating conditions. The main means of ensuring functional stability is the introduction of redundancy (structural, software, time, etc.) during their design. The paper analyzes the existing scientifically based approaches to increasing the efficiency of complex technical systems, which include an intelligent automated control system. A technique for determining the features and indicators of the functional stability of the special purpose network structure, which provides communication between the UAV group and the operator, is proposed. Quantitative methods for assessing functional stability based on the above indicators are proposed. On the basis of these assessments, recommendations can be made on the construction of the structure or reasonable requirements for the structure of the wireless sensor network that will be designed and operated can be formulated. the main feature of functionally stable systems. It has been established that this is their ability to degrade at the structural level until the complete failure of the system, that is, to exclude defective elements from the structure, rebuild the structure, and adjust the system parameters to adapt to new operating conditions. It has been proven that the main means of ensuring functional stability is the introduction of excesses into their construction: structural, program, time, etc.
ВИЯВЛЕННЯ ТА БЛОКУВАННЯ ПОВІЛЬНИХ DDOS-АТАК ЗА ДОПОМОГОЮ ПРОГНОЗУВАННЯ ПОВЕДІНКИ КОРИСТУВАЧА
Authors: Лаптєв Олександр , Бучик Сергій , Савченко Віталій , Наконечний Володимир , Михальчук Інна , Шостак Яніна
Published: December 2022

Особливістю повільної DDoS-атаки є використання вразливості в протоколі TCP/IP, де навмисно чи ненавмисно можуть бути викликані переривання в результаті затримки в каналах зв'язку. У статті розглядається проблема виявлення повільної розподіленої атаки відмови в обслуговуванні. Відомо, що виявлення повільних DDoS-атак відрізняється від атак на основі обсягу трафіку, оскільки вони не збільшують інтенсивність трафіку в мережі. Замість створення раптового надлишку тра[1]фіку, повільні малопотужні атаки проводяться з мінімальною активністю і не реєструються сис[1]темами. Вони спрямовані на те, щоб вивести об'єкт з ладу непомітно, створюючи мінімальну кіль[1]кість підключень та залишаючи їх незавершеними якомога довше. Як правило, зловмисники відправ[1]ляють часткові запити HTTP і невеликі пакети даних або повідомлення для перевірки активності, щоб підключення залишалося активним. Подібні атаки важко заблокувати, і складно виявити. У зв'язку з малим обсягом трафіку, а також з тим, що атаки можуть виглядати як стандартні підк[1]лючення, потрібна інша технологія запобігання. Джерела атак необхідно блокувати, виходячи з осо[1]бливостей виконання запитів, а не на основі їх репутації. Тому було зроблено припущення про залеж[1]ність успішної повільної DDoS-атаки залежить та поведінки користувача. На основі моделювання методу виявлення повільних атак було проведено дослідження та прогнозування поведінки особис[1]тості, запропоновано траєкторію поведінки конкретного користувача. Можливості застосування такого методу підтверджено моделюванням атак RUDY на HTTP-сервіси. Отримані характерис[1]тики точності прогнозування залежно від відображуваного накопиченого трафіку і статистики атак. Дослідження доводить, такий метод можна використовувати для виявлення різних типів по[1]вільних DDoS-атак
Spatial distribution of apiaries in the municipality of Ribeira do Pombal, Bahia, Brazil
Authors: Gama Dráuzio Correia , Oliveira Favízia Freitas de , Jesus Janisson Batista de
Published: December 2022

The number of beehives installed per apiary should take into account the potential of bee pasture, the existence of nearby apiaries and ease of management. The study aimed to analyze the spatial distribution of apiaries in the municipality of Ribeira do Pombal, State of Bahia, Brazil, in order to estimate the production of honey per apiary based on the relationship between the number of hives established and the distance between apiaries. For the analysis of spacing, a image of the municipality was acquired by the Landsat-8 satellite and the location points of the georeferenced apiaries. The apiaries were grouped into Classes according to the number of hives: <25 hives.apiary-1 (I), 25-30 (II) and> 30 hives.apiary-1 (III). The apiaries were projected on a map with 1,500 m buffer corresponding to the radius of action of the bees’ flight. A total of 7,198 hives were computed in 290 apiaries distributed in classes: I (47.58%), II (23.45%) and III (28.96%). There were 4.14% apiaries without overlap; and class I apiaries (97%) showed greater overlap. We recommend zoning the beekeeping potential and planning the distribution of apiaries in order to meet the carrying capacity, logistical optimization and for higher productive yield.
Qualitative case study of the dynamics of the patient's anxiety level in relations with relatives and friends: an analysis of a single case of psychoanalytic counseling
Authors:   Moscow Region State University, Zhmurin I.E. , Korneichik I.V. ,   Moscow Region State University
Published: December 2022

Introduction. The model of studying a single case and considering this version of the study of psychotherapy were implemented for the first time within the boundaries of the psychoanalytic paradigm. Today, this type of research is recognized and has promising developments in various areas and schools of psychotherapeutic practice. While there is some disagreement among academic psychologists and representatives of psychotherapy practice regarding the effectiveness of this method, it has a rather strong argument in favor of its application. The advantages of this method include: close attention to the acquisition of concrete, practical, contextual knowledge, as opposed to universal theo-retical knowledge without taking into account the context; the use of more flexible re-search standards and obtaining detailed data on the problem being solved. Methodology and methods: a qualitative case study of a group of isolated cases was conducted in 2018-2022 and was part of a pilot study to assess the effectiveness of psychoanalytic counseling of patients with high levels of anxiety. Patient indicators were collected us-ing psychodiagnostic techniques and recording material for sessions of 5 patients. To implement a qualitative thematic analysis of the dynamics of changes in the level of anx-iety, diagnostic tools have been developed to assess the manifestation of anxiety indica-tors in the speech of patients, based on the theoretical provisions of psychodynamic psy-chodiagnostics of anxiety. Results and conclusions. The results of a qualitative case study of the dynamics of anxiety and its impact on patients' relations with relatives and friends in the course of psychoanalytic counseling are presented. Analysis of the mani-festation of anxiety in the speech of patients showed that its decrease is reflected in less pronounced references to excitement, tension and negative feelings towards relatives and friends, and the semantic analysis of patients' speech with the help of the text anal-ysis program showed subtle movements in the semantic structure of their statements. Changes in the semantic structure of patients' speech reflect the individual way of their awareness of the problems under discussion and are reflected in the emergence of new semantic connections of the central
Mobile learning as a tool for motivating students to learn a foreign language in higher education
Authors:   Tula State University, Semenova G.V. , Vorobyeva N.V. ,   Tula State University
Published: December 2022

Introduction. The current stage of development of the system of foreign language educa-tion in Russia takes place within the framework of global digitalization. Mobile learning as one of its innovative tools is rapidly penetrating the process of mastering a foreign language, helping to diversify and optimize the learning process for the modern genera-tion of students. The use of mobile technologies in the foreign language educational process helps to increase the motivation of students to study a foreign language at a uni-versity. The purpose of the research is to study and analyze the impact of the use of mo-bile technologies in teaching a foreign language on the motivation of students to study the discipline. Materials and methods include: theoretical analysis of scientific, pedagog-ical and methodological literature on the research topic, pedagogical observation, ques-tionnaire, conversation, analysis of research results. In the foreign language educational process, along with traditional methods, elements of mobile learning were used to iden-tify its impact on the motivation of students to learn a foreign language. Results. Posi-tive dynamics was observed, the level of motivation for the discipline studied by stu-dents of experimental groups increased significantly compared to control groups. Con-clusions. Mobile technologies have didactic potential when learning a foreign language. Using them as a tool to create motivation for learning the subject, it is possible to learn a foreign language more effectively: interest in the discipline and involvement in the edu-cational process are strengthened. Thanks to the use of mobile devices familiar to mod-ern youth, which allow you to visualize objects, gamify the learning process, introduce interactivity and make it possible to individualize the process of mastering knowledge, the level of motivation to learn a foreign language increases.
Features of self-presentation of Russian teachers with different levels of empathy
Authors:   Kostroma State University, Chagina A.V.
Published: December 2022

Introduction. The modern educator needs to master new forms and methods of effective communication in his or her professional life. The problem of teachers' self-efficacy and successful self-presentation tactics is very relevant. In this regard, it becomes productive to study the relationship of empathy with self-presentation strategies and teaching styles among school teachers. The purpose of the article was to determine the relationship of empathy with the tactics of self-presentation of teachers. The main research methods are the “Teacher Empathy Scale” (Wang, et al, 2022), the questionnaire “Teacher Roles Scale” (Stojiljković, et al, 2012) and the questionnaire “Scale of self-presentation tac-tics” (Lee, et al, 1999). 116 teachers from the regions of Russia took part in the survey, 94.5% of them were women. SPSS 19.0 programs were used for data processing. Re-search results: the most common tactics of self-presentation among Russian teachers are apology, role model and renunciation. Among the least popular are bullying, negative evaluation of others, exaggeration of their achievements. The tactics of self-presentation were associated with the level of empathy: the closest relationship was revealed with the tactics of “attractive behavior” and “request/ plea”. The tactics of self-presentation turned out to be interrelated with the teaching roles: the pedagogical role is intercon-nected with the tactics of “hindering oneself” and “communicating one's achievements”, as well as “an example to follow”. The motivational role is interconnected with the tac-tics of “hindering oneself”, the cognitive-diagnostic role is interconnected with the tac-tics of “role model”. The role in affective interaction is interrelated with the tactics of self-presentation: “justification with denial of responsibility”, “justification with ac-ceptance of responsibility”, as well as with “desire/effort to please”. Conclusions: the most preferred strategies of self-presentation among Russian teachers are avoidance as evasion of responsibility and avoidance of decisive actions and attractive behavior as behavior that causes a favorable impression of the subject of self-presentation. This should be taken into account when building work with teachers in the school system.
Identifying Different Musical Instrument Sounds Using Fourier Analysis in LabVIEW
Authors: Pamuk Nihat
Published: December 2022

In this study, we found that the relationship between the Fast Fourier Transform (FFT) and music is more suitable than other methods. The LabVIEW program is capable of implementing the FFT in a shorter time, which is used to convert a signal from the time zone into a frequency field. FFT was used to find harmonics in musical notes, model sound waves, and define sound by breaking it into pieces. The amplitude of the sound received from the filtered analog input after FFT is applied is kept above the amplitude threshold level to prevent noise (low voice). If the frequency of the selected tuning note is in the specified frequency (despite possible deviations) range, tuning control is provided and the notation is performed. At the same time, spectral analysis can be examined thanks to FFT. The user can select the instrument and note they want on the interface screen. In the application, it was ensured to examine the notation and tuning process used in the intended standard reference data.
The Influence of COVID-19 in Systematizing the Work and Introducing Organizational Changes in Small Enterprises
Authors: Magdinceva-Sopova Marija , Stojanovska-Stefanova Aneta
Published: December 2022

The new condition and the changes in the working environment due to the long duration of the pandemic caused substantial insecurity among the employees. Employees and managers face difficult challenges in performing their job responsibilities. This paper aims to point out the role of the management in gathering the preconditions for the implementation of the organizational changes as well as timely recognition and detection of the employee’s necessities for the introduction of the changes. The results of the research confirm the hypothesis that the impact of the COVID-19 caused the implementation of these organizational changes, which are dependent on accomplishing the preconditions for the introduction of organizational changes.
Inflammation-Schizophrenia: A Bidirectional Causal Association Mediated by Cytokines
Authors: Shamabadi Ahmad , Akhondzadeh Shahin
Published: December 2022

The Article Abstract is not available.
Opportunistic Challenges of Computer-aided Drug Discovery of Lipopeptides: New Insights for Large Molecule Therapeutics
Authors: Yadav Manisha , Eswari J. Satya
Published: December 2022

Computer-aided drug designing is a promising approach to defeating the dry pipeline of drug discovery. It aims at reduced experimental efforts with cost-effectiveness. Naturally occurring large molecules with molecular weight higher than 500 Dalton such as cationic peptides, cyclic peptides, glycopeptides and lipopeptides are a few examples of large molecules which have successful applications as the broad spectrum antibacterial, anticancer, antiviral, antifungal and antithrombotic drugs. Utilization of microbial metabolites as potential drug candidates incur cost effectiveness through large scale production of such molecules rather than a synthetic approach. Computational studies on such compounds generate tremendous possibilities to develop novel leads with challenges to handle these complex molecules with available computational tools. The opportunities begin with the desired structural modifications in the parent drug molecule. Virtual modifications followed by molecular interaction studies at the target site through molecular modeling simulations and identification of structure-activity relationship models to develop more prominent and potential drug molecules. Lead optimization studies to develop novel compounds with increased specificity and reduced off targeting is a big challenge computationally for large molecules. Prediction of optimized pharmacokinetic properties facilitates development of a compound with lower toxicity as compared to the natural compounds. Generating the library of compounds and studies for target specificity and ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) for large molecules are laborious and incur huge cost and chemical wastage through in-vitro methods. Hence, computational methods need to be explored to develop novel compounds from natural large molecules with higher specificity. This review article is focusing on possible challenges and opportunities in the pathway of computer-aided drug discovery of large molecule therapeutics.
An Anti-TAZ Monoclonal Antibody Recognizing Cell Surface Expressed TAZ Protein in Human Tumor Cells
Authors: Ghaffari Mozhan Haji , Mohammadzadeh Mahsa , Simonian Miganoosh , Hashemi Mehrdad , Sadeghi Niloufar , Negahdari Babak , Mazloomi Mohammadali , Rabbani Hodjattallah
Published: December 2022

Background: WWTR1 or TAZ is a transcriptional co-activator protein expressed in cytoplasm which functions as the main downstream effector of the Hippo signaling pathway. This pathway is an evolutionally conserved signal cascade, which plays a pivotal role in organ size control and tumorigenesis. Ectopic expression of TAZ has already been observed in many malignancies, while the ectopic localization of TAZ is reported for the first time. The aim of this study was to produce a specific monoclonal antibody (mAb) against a synthetic peptide derived from WWTR1 protein to be used as a research tool in human carcinomas.
Methods: A 21-mer synthetic peptide (derived from human TAZ protein) was used for immunization of BALB/c mice after conjugation with Keyhole Limpet Haemocyanin (KLH) using hybridoma technology. The generated mAb reacted with the immunizing peptide employing ELISA assay. The reactivity of the antibody with native TAZ protein was assessed through Western blot, immunocytochemistry, and flow cytometry using different cancer cell lines.
Results: The produced mAb could recognize the immunizing peptide in ELISA and Kaff was 0.6×10-9 M. The produced anti-TAZ mAb unlike available commercial anti-TAZ antibody, was capable of specifically recognizing cell surface TAZ in human carcinoma cell lines including MCF-7, Raji, and A431 in Western blot, immunocytochemistry, and flow cytometry assays. As expected, no reactivity was observed using normal Peripheral Blood Mononuclear Cell (PBMC) from healthy donors.
Conclusion: Based on the results, TAZ is ectopically expressed on the surface of tumor cell lines which is not the case in normal cells. The generated mAb has a potential to be used as a research tool in studying the expression of TAZ in human carcinomas in different applications.
Proteome Analysis of Adult Acute Lymphoblastic Leukemia by Two-dimensional Blue Native/Sodium Dodecyl Sulfate Gel Electrophoresis
Authors: Bagheralmoosavi Servin , Gholami Parastou , Amini Mahdi , Alizadeh Mahdi , Yaghmaei Marjan , Tavakkoli Sahar , Salari Sina , Jeddi-Tehrani Mahmood , Ghasempour Alireza , Gilany Kambiz , Shabani Mahdi
Published: December 2022

Background: Despite the significant progress in the treatment of Acute Lymphoblastic Leukemia (ALL) in children, it still remains as one of the most challenging malignancies in adults. Identification of new biomarkers may improve the management of adult ALL. Proteins expressed on the cell surface can be considered as disease-associated biomarkers with potential for diagnosis and targeted therapies. Thus, membrane proteome studies give essential information about the disease-related biomarkers.
Methods: We applied 2-dimensional blue-native SDS-PAGE technique followed by MALDI-TOF/TOF-mass spectrometry to study the cell membrane proteome of peripheral blood mononuclear cells of adult B-ALL patients in comparison to that of the healthy controls.
Results: Sixty seven differentially expressed protein spots were detected, among them 52 proteins were found to be up-regulated but the other 15 proteins were down-regulated in B-ALL. Five differentially expressed proteins, involved in energy metabolism pathways, were detected in B-ALL patients compared to the healthy control group.
Conclusion: Differentially expressed proteins provide an insight into the molecular biology of B-ALL. Further studies must be done to confirm our data to be considered as potential targets for detection and treatment of B-ALL.
Optimization of Degenerate PCR Conditions for Reducing Error Rates in Detection of PKS and NRPS Gene groups in Actinomycetes
Authors: Ghashghaei Sara , Etemadifar Zahra , Tavassoli Manoochehr , Mofid Mohammad Reza
Published: December 2022

Background: The screen of Polyketide Synthase (PKS) and Nonribosomal Peptide Synthetase (NRPS) gene groups is a quick way to discover new therapeutic agents. However, errors in laboratory techniques cause a loss of touch with reality. This study aimed to evaluate the presence of PKS and NRPS gene groups in previously isolated strains by optimizing their specialized amplification by degenerate primers and indicating the evolutionary relationships with reference strains.
Methods: PKS-I, II, and NRPS genes PCR amplification was performed using three degenerate primer sets for 22 actinomycete strains with antibacterial activity. Annealing temperature and the amount of template DNA and primers were optimized. PCR products of PKS-I, II, and NRPS from three strains were sequenced after TA cloning. Besides, strains with high antibacterial activity were identified by biochemical features and partial 16S rDNA sequencing and hypothetically classified by a phylogenetic tree.
Results: High frequencies of PKS-I (86.4%), PKS-II (81.8%), and NRPS (95.4%) genes were found among the strains after optimization. Fourteen strains (64%) contained all of the genes, and 100% of strains had at least two genes. These numbers are pretty distinct in comparison with the previous researches. All of the sequenced strains were members of Streptomyces genus.
Conclusion: Our research showed that degenerate PCR strongly depends on the variation of annealing temperature and primer concentration, resulting in an unexpected shift in PCR outputs. The sequencing results confirmed the optimized conditions for specialized PCR of PKS-I, PKS-II, and NRPS gene groups.
Formulation, Characterization, and Evaluation of Wound Healing Potency of a Novel Mattan tailam Nanogel Based on a Famous Traditional Siddha Formula
Authors: Sakthiganapathi Meenachisundaram , Yoganandam Gnanakumar Prakash , Gopal Venkatachalam
Published: December 2022

Background: The Mattan tailam mixture has been extensively used to heal ulcerous wounds in traditional Siddha practice. The present study aimed to synthesize a Mattan tailam nanogel and evaluate the enhancement of wound healing potential in an experimental wound model.
Methods: Mattan tailam nanogel was synthesized using the high-energy milling approach, and characterization of nanogel and potency of wound healing was investigated. The novelty of this study was the nanogel preparation of Mattan tailam.
Results: As expected, a synthesized novel nanogel of Mattan tailam has a distinct, prominent peak with a spherical form, is negatively charged and has an average particle size of 20–30 nm. Mattan tailam nanogel treated rats showed a remarkable reduction (p<0.001) in the wound area. On the 16th day, 10% Mattan tailam nanogel treatment resulted in a higher percentage of wound contraction. The 10% Mattan tailam nanogel group exhibited a faster epithelialization time (14.33 days) and a greater hydroxyproline concentration than the others. The topical application of 10% Mattan tailam nanogel increased tensile strength, signifying a better therapeutic indication.
Conclusion: The present findings prove that polyherbal Mattan tailam nanogel formulation significantly improves collagen production, wound contraction, and tensile strength.
Identification of Critical Molecular Factors and Side Effects Underlying the Response to Thalicthuberine in Prostate Cancer: A Systems Biology Approach
Authors: Saberi Fatemeh , Dehghan Zeinab , Noori Effat , Taheri Zahra , Sameni Marzieh , Zali Hakimeh
Published: December 2022

Background: Uncontrolled mitosis of cancer cells and resistance cells to chemotherapy drugs are the challenges of prostate cancer. Thalicthuberine causes a mitotic arrest and a reduction of the effects of drug resistance, resulting in cell death. In this study, we applied bioinformatics and computational biology methods to identify functional pathways and side effects in response to Thalicthuberine in prostate cancer patients.
Methods: Microarray data were retrieved from Gene Expression Omnibus (GEO), and protein-protein interactions and gene regulatory networks were constructed, using the Cytoscape software. The critical genes and molecular mechanisms in response to Thalicthuberine and its side effects were identified, using the Cytoscape software and WebGestalt server, respectively. Finally, GEPIA2 was used to predict the relationship between critical genes and prostate cancer.
Results: The POLQ, EGR1, CDKN1A, FOS, MDM2, CDC20, CCNB1, and CCNB2 were identified as critical genes in response to this drug. The functional mechanisms of Thalicthuberine include a response to oxygen levels, toxic substances and immobilization stress, cell cycle regulation, regeneration, the p53 signaling pathway, the action of the parathyroid hormone, and the FoxO signaling pathway. Besides, the drug has side effects including muscle cramping, abdominal pains, paresthesia, and metabolic diseases.
Conclusion: Our model suggested newly predicted crucial genes, molecular mechanisms, and possible side effects of this drug. However, further studies are required.
Monkeypox Outbreaks in Non-Endemic Countries: Correspondence
Authors: Mungmunpuntipantip Rujittika , Wiwanitkit Viroj
Published: December 2022

The Article Abstract is not available.
WAYS OF MANIFESTATION OF THE AUTHOR-CHARACTER IN CONTEMPORARY DRAMA
Authors: Kozhina Maria A.
Published: December 2022

In the contemporary drama, that is, plays written in recent decades, the voice of the author is becoming more and more distinguishable. It occurs not only in the title, the list of characters, remarks and other elements of the paratext, as it was before, but also directly in the text. In new plays, playwrights often bring out a character who is close to them, real people, with the facts of his biography, views on life, and so on (let’s call him the author-character). In the article, we consider how the author-character relates to the representations of the “image of the author” in a work of art, how it manifests itself in contemporary drama, and how the relationship between the author and the reader / viewer is built in the text. Plays written from 1991 to 2021 were selected as material — “Cherepakha Manya” (“Manya the Turtle”) by Nikolai Kolyada, “Khozyain kofeyni” (“Coffee House Owner”) by Pavel Pryazhko, “Zapis’ preryvayetsya” (“The Recording Is Interrupted”) by Elina Petrova and “Plotnik” (“The Carpenter”) by Lidia Golovanova.
IMPROVING THE QUALITY OF TEACHING RUSSIAN LANGUAGE AND LITERATURE BY MEANS OF FORMATIVE ASSESSMENT
Authors: Andreeva Olga S.
Published: December 2022

The study identifies the developing and motivating potential of formative assessment in the context of the updated Federal State Educational Standard for Basic General Education. Educational deficits that actualize the need to introduce criteria-based assessment at school are revealed. On the basis of the system-activity approach, criteria and indicators for assessing the level of students’ achievements in individual topics have been developed for current control. Tables of self-assessment of the achievements of students in the lessons of the Russian language and literature on the basis of criteria-based assessment have been developed to determine the level of formation of the educational and cognitive competence of schoolchildren, the relationship between the evaluation criteria and the requirements for the results of mastering the exemplary educational program in the Russian language and literature has been identified. The experience of implementing criteria-based assessment in the process of teaching the Russian language and literature proves that the work of students with self-assessment tables contributes to the development of meta-subject skills and the achievement of personal results, increases interest in learning and allows you to build an individual educational route for the student.
THE STUDING OF LEO TOLSTOY.S CREATIVITY: TALK ABOUT THE RUSSIAN BALL
Authors: Kachan Yulia E.
Published: December 2022

This article analyses the function of integrated lessons, and emphasizes their necessity for a group of foreign students. The purpose of the study is to identify the features of an integrated lesson for foreign students based on the lesson developed by the author. Literature lesson dedicated to the ballroom theme in the works of Leo Tolstoy is being integrated with other disciplines of the humanities, and various types of art. The emphasis is made on literary, historical, and linguistic coverage of this European phenomenon, transferred to the public life of Russia. Questions and assignments are focused on the development of speech, strengthening the skill of independent work, expanding the lexical and cultural vocabulary of students. The concept of integrative learning is being defined in relation to a foreign group of students; the specificity of interdisciplinary connections for given conditions is determined, the results of the experiment are analyzed.
NATIONAL PECULIARITIES OF THE REALIZATION OF COMFORTING STRATEGY IN GERMAN LINGUACULTURE
Authors: Gokova Ekaterina I.
Published: December 2022

The article is devoted to the study of comforting communicative strategy. The tactics and linguistic means realizing it differ from one lingua-culture to another. The relevance of the article is due to the need for further study of this strategy in German lingua-culture. The purpose of this work is to define the tactics and linguistic means that realize comforting strategy in German speech, as well as their national peculiarities. According to the analysis of empiric material, the following tactics can be distinguished: soothing tactics, distraction tactics, empathy tactics, optimism tactic, fatalism tactic, support tactics, generalization tactics, mobilization tactics, tactics of perspective change, of feelings explication, of reference to personal experience, of opponent’s criticism, of ways of coping suggestion. The author comes to the conclusion that the realization of comforting strategy in German speech reflects the following national peculiarities. The speakers appeal to the listener’s logic and give a detailed argumentation of their ideas. They criticize the lack of rationality in the other’s behavior. The idea of a norm is of great importance. The norm refers to the emotional stability, peace of mind and confidence. A comforting message aims to help the consoled get back to this norm. It is also connected with Ordnung, Sicherheit concepts A comforter can also appeal to the Pflicht concept. The study also shows that the speaker tries to alleviate the listener’s feeling of uncertainty and appeals to Zeit concept.
RUSSIAN WORLD AND IT`S SIGNS IN THE “CORRESPONDENCE OF ANDREI KURBSKY WITH IVAN THE TERRIBLE”
Authors: Tishchenko Аleksey S.
Published: December 2022

The theme of the ‘Russian World’ is permanent in national literature, and rather often it is closely connected with socio-political processes. The 16th century played a special role in the history of Russia, determining, to a great degree, the ways of further development of the country and posing significant political, philosophical, and social issues; the key historical figure of the period was Ivan the Terrible, whose reign is associated with the strengthening of an united centralized Russian state headed by Moscow and the expansion of the state. The discussions in his letters to Ivan the Terrible (the correspondence between Andrey Kurbsky and Ivan IV the Terrible of Russia) became a dispute about the Russian World. The correspondence reflected polar views on the same issues: the power and the figure of the ruler, the form of government, the ratio of statehood and the Orthodoxy, the loyalty of subjects to the ruler. The discussions in the letters of Kurbsky and Ivan the Terrible form a special image of the ‘Holy’ Russian Land, the ‘Kingdom of God’, and the phrase ‘the Russian land’ is used in the correspondence in the civilization sense. The message of Ivan the Terrible reflects the motive of the selection of Russia as a stronghold of the Orthodoxy; the Tsar speaks about the protection of the Orthodox faith by any means, even the cruelest ones. Autocracy, according to Ivan the Terrible, is inseparable from the Orthodox Christianity. The dialogue between the tsar and the prince is considered in the context of the opposition lines of ‘mine or ours, my or our own’ – ‘alien’, ‘the Russian world’ and ‘non-Russian one’: Kurbsky writes from abroad and is perceived as a traitor. The material of the letters highlights the signs and features of the Russian World as a special integral phenomenon: the Orthodoxy, selectivity, commonality and similarity of history and culture, Messianism.
Cardioprotective Diet: A Possibility of Diet Therapy Treatment
Authors: Garcia Luz Edith , Patricia Cintra , Leão Nogueira Holsbach Anderson , Ângela Alves Nunes , Oliveira Thaís Anastácio de
Published: December 2022

The Brazilian Cardioprotective Diet is a diet for patients with heart disease, but it provides health benefits when used as an adjuvant in the prevention and treatment of diseases that have food as one of the factors for their development. It was developed by Hcor in partnership with the Ministry of Health in 2018. It classifies and recommends the consumption of foods by groups: green, yellow, and blue, using the Food Guide for the Brazilian Population as a referência. The objective of this study was, through a literature review, to find scientific data on the cardioprotective diet. This diet indicates the inclusion or exclusion of food from the values of food density (kcal, saturated fat, cholesterol, and sodium).Studies have pointed out that the excessive intake of ultra-processed foods is associated with practicality of eating, afforda prices, and easy availability of products, and therefore these foods have become cheaper compared to fresh, minimally processed foods, and the ultra-processed foods are the main responsible for the increase in non-transmissible chronic diseases. The cardioprotective diet shows the significant effect on the modulation of inflammatory response, through the intake of several nutrients and bioactive compounds from food, which act by activating the signaling pathways involved in the synthesis of inflammatory biomarkers. Therefore, although there are few published studies on cardioprotective food and being it effective in the secondary treatment of chronic noncommunicable diseases, it is necessary to conduct research among nutritionists to know the difficulties of assistance within the Public Health System.
Hyperthyroidism and Covid-19, Early or Late: A Case Series from South-West Nigeria
Authors: Esan Arinola , Ehizode Emuze Martins , Adekanmbi Olukemi
Published: December 2022

The Coronavirus disease 2019 (COVID-19) pandemic has put the world on its toes for more than 2 years. It is caused by a novel virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Initial symptoms associated with the virus were mainly respiratory in nature but over time, varied presentations have been noted in persons infected with the disease. Research has shown that COVID-19 can cause both pulmonary and systemic inflammation, which may result in multi-organ dysfunction. The effects of COVID-19 on metabolism including glucose regulation and diabetes mellitus have been highlighted in literature and it is now known that persons with poorly controlled diabetes will most likely have a poor clinical outcome when infected with SARS-CoV-2. Biochemical abnormalities of the thyroid hormones during and post-COVID infection have been noted by some authors, however, there is scanty information available in sub-Saharan Africa. The essence of this case series is to document the experience of an endocrine facility as regards thyroid abnormalities observed in persons who presented with confirmed COVID-19 infection and COVID-19 related symptoms without confirmation by PCR.
Critical pedagogy and beyond
Authors: Gounari Panayota , Morelock Jeremiah , Narita Felipe Ziotti
Published: December 2022

An interview with Panayota Gounari. The interview was organized and coordinated by Jeremiah Morelock and Felipe Ziotti Narita.
Critical pedagogy and radical political economics
Authors: Reitz Charles , Spartan Stephan
Published: December 2022

An in-depth examination of political economy, especially the social dynamics of economic inequality, is a vital part of radical pedagogy. This essay explicates Herbert Marcuse’s critique of the global political economy, U.S. militarism, and his educational philosophy. Marcuse's critical pedagogy stresses that educators at every level face the necessity of elaborating the theory and practice for a free world order today: one of racial equality, women’s equality, the liberation of labor, the restoration of nature, leisure, abundance, and peace.
A Freirean deconstruction of online education in Algeria
Authors: Sarnou Dallel
Published: December 2022

In his seminal and highly influential work Pedagogy of the Oppressed (1970), the Brazilian scholar Paulo Freire refers to education as “becoming an act of depositing, in which the students are the depositories and the teacher is the depositor.” Freire strongly criticizes what he calls “the banking model” of education, whether in schools colleges or universities. This model of pedagogy is prevalent and dominant in many countries of the world, and in Algeria–the country under focus in this paper. Nonetheless, with the many advanced technologies that are being integrated into educational institutions all over the world with the aim of building a more learner-centered pedagogy, Freire’s claims and views have recently been subject to many re-readings and revisions by contemporary educators.  More particularly, on the recent attempts of the last couple of years to shift into online education so as to save the learning and teaching processes during the confinement imposed by the COIVD 19 pandemic, much ink has been spilled regarding the sudden and forced appliance of MOODLE platform in Algeria. The latter, as will be argued throughout this paper, is nothing but a re-incarnation of Freire’s banking model. Therefore, a pivotal query in the present paper is to unveil how online education in Algeria applied since the outbreak of the Corona pandemic does correspond to Freire’s Pedagogy of the Oppressed where the oppressed is always the learner.
Motivasi rumah baca Asma Nadia Ciranjang, Cianjur berkolaborasi dengan relawan dalam pemberdayaan masyarakat
Authors: Widyawati Wiwit , Winoto Yunus , Khadijah Ute Lies Siti
Published: December 2022

Rumah Baca Asma Nadia Ciranjang (RBA Ciranjang) merupakan rumah baca yang memiliki fokus dalam meningkatkan minat baca di daerah Ciranjang sebagai bentuk upaya pemberdayaan masyarakat. Tujuan penelitian ini adalah untuk mengetahui latar belakang terjalinnya kolaborasi dan motivasi yang muncul dari pihak RBA Ciranjang dan Relawan. Metode penelitian yang digunakan adalah metode kualitatif dengan pendekatan studi kasus. Teknik pengumpulan data yang digunakan yaitu observasi langsung, wawancara dan studi kepustakaan. Teknik analisis datanya menggunakan  tahap reduksi data, penyajian data dan pengambilan keputusan. Hasil dari penelitian ini menjelaskan bahwa latar belakang terjalinnya kolaborasi adalah RBA Ciranjang membutuhkan Sumber Daya Manusia (SDM) yaiu relawan. Latar belakang RBA Ciranjang membutuhkan SDM adalah untuk menjalankan kegiatan berbasis literasi sebagai salah satu upaya memberdayakan masyarakat. Kolaborasi yang terjalin pun timbul didasari dari motivasi, baik dari RBA Ciranjang dan relawan. Motivasi relawan didasari dari volunteer self-efficacy, yaitu keyakinan relawan bahwa dirinya dapat tampil dalam kegiatan sukarela. Munculnya motivasi dalam diri relawan di dasari dari semangat mereka untuk mengabdikan dirinya kepada masyarakat. Rendahnya minat baca di Indonesia membuat RBA Ciranjang dan relawan siap meningkatkan budaya membaca di lingkungan Ciranjang. Untuk kedepannya, bagi TBM yang memiliki kendala keterbasan SDM, bisa melakukan kolaborasi dengan pihak lain.