bluuebunny/crossref_metadata_2025 huggingface dataset:
The Immunohistocehmical Expression of Beta Human Chorionic Gonadotrophin (β-HCG) in Different Grades of Human Papillary Urothelial Neoplasm
Authors: Ammara Anwar  , Aamir Imtiaz Khan  , Asmaa Qureshy  , Muhammad Tahir Bashir Malik  , Asima Naz  , Khawaja Moeen ud Din
Published: February 2024

Background: Urothelial carcinomais the most common urological malignancy and following prostate and lung cancer, it is the third most common carcinoma in male population.
Objective: The main aim of this study was to determine the expression of beta hCG in different grades of human urothelial carcinoma in our population.
Methods: The study was conducted in Pathology Department of Faisalabad Medical University, Faisalabad, between 2018-2020.Sections were taken on frosted slides for H& E, and on lysine coated slides for IHC.H& E and IHC were performed according to protocols.
Results:  Out of the 65 tumor studied, 35(54%) were graded as low and 30(46%) were graded as high. In 35 low grade tumors 4(11%) were muscle invasive and 31(89%) were non-invasive and in 30 high grade tumors, 24(80%) were found to be muscle invasive and only 6(20) were non muscle invasive. Out of 65 specimens, 52 (80%) cases were found to be positive for beta hCG while only 13(20% ) were found to be negative of  35 low grade tumors,  27(77%) tumors were stained positive for beta hCG and 8(23%) were negative. Of 30 high grade tumors 25(83%) tumors were stained positive for beta hCG and 5 (17%) were negative. Chi-square test was applied showed that there was no significant association between tumor grade and beta hCG expression.
Conclusion: The immunohistochemical expression of beta hCG is positive in majority of low and high grade urothelial carcinoma but it may not be utilized as a marker for prognostic determination.
Detection and quantification of adenovirus, polyomavirus, and papillomavirus in urban sewage
Authors: Shaheen Mohamed N. F. , Ahmed Nehal , Rady Badr Kareem , Elmahdy Elmahdy Mohamed
Published: February 2024

The objective of this study was to assess the occurrence and seasonal frequency of human adenovirus (HAdV), human polyomavirus (HPyV), and human papillomavirus (HPV) in urban sewage. The detection of these viruses was carried out by polymerase chain reaction (PCR), and then the viral concentrations in the positive samples were quantified by quantitative PCR (qPCR). Additionally, HAdV and HPyV genotyping was also performed by PCR. A total of 38/60 (63.3%) positive samples were found. HAdV was the most prevalent virus (26/60; 43.3%), followed by HPyV (21/60; 35%) and HPV (21/60; 35%). The viral concentrations ranged from 3.56 × 102 to 7.55 × 107 genome copies/L. The most common dual viral agents was found between HAdV and HPyV, in eight samples (8/38, 21%). HAdV types 40 and 41 as well as HPyV types JC and BK were identified, with HAdV-40 and HPyV JC being the most prevalent types. Furthermore, the detection rates of HAdV, HPyV, and HPV were higher during the winter season than the other seasons. The high prevalence of HAdV and HPyV supports their suitability as viral indicators of sewage contamination. Furthermore, this study demonstrates the advantages of environmental surveillance as a tool to elucidate the community-circulating viruses.
Mujer es cosmos: una mirada de género entre los ikᵾ de la Sierra Nevada de Santa Marta
Authors: Archetti Chiara
Published: February 2024

En este artículo se explora la dimensión del género y el origen de la construcción sexual entre los ikᵾ (arhuaco), grupo de lengua chibcha, que habita en la Sierra Nevada de Santa Marta (SNSM), en el caribe colombiano. Las reflexiones que aquí se presentan surgieron durante diversas estancias de trabajo de campo (2022 y 2023) realizadas en las comunidades ikᵾ de Sabana Crespo, Gunkarwan y Nabusímake, en el departamento del Cesar, región oriental de la SNSM. Aquí se discute cómo los procesos de formación de las diferencias del género adquieren formas específicas y están enraizadas en los rituales del período de desarrollo. La sangre, jwa, en el periodo de la primera menstruación, o munseymuke, oscila entre dos fuerzas (duna y gansigna) y tiene agencia diferente a la de los fluidos sexuales masculinos. La mujer menstruante y el cuerpo femenino con sus fluidos revelan criterios distintivos en la socialización de los roles del género por su incidencia en los rituales de intercambio y pagamento a los seres del cosmos.
Traditional Uses, Phytochemistry, and Pharmacological Activities of Coleus
amboinicus: A Comprehensive Review
Authors: Paul Karthika , Gowda Benachakal Honnegowda Jaswanth , Hani Umme , Chandan Ravandur Shivanna , Mohanto Sourav , Ahmed Mohammed Gulzar , Ashique Sumel , Kesharwani Prashant
Published: February 2024

Coleus amboinicus Benth., also known as Plectranthus amboinicus (Lour.) Spreng., is a perennial
plant from the Lamiaceae family commonly found in tropical and warm regions of Africa, Asia, and Australia.
Folk medicine commonly employs this remedy to address various ailments, including but not limited to asthma,
headaches, skin disorders, coughs, constipation, colds, and fevers. Several phytoconstituents from various
phytochemical classes, such as phenolics, terpenoids, phenolic acids, flavonoids, flavones, and tannins, have
been identified in Coleus amboinicus up to the present time. Numerous pharmacological properties of Coleus
amboinicus crude extracts have been documented through both in vitro and in vivo studies, including but not
limited to antitumor, antibacterial, antifungal, antiprotozoal, anti-inflammatory, antioxidant, antidiabetic,
wound healing, analgesic, antirheumatic, and various other therapeutic effects. Due to its extensive history of
traditional usage, the diverse array of bioactive phytochemicals, and numerous established pharmacological activities,
Coleus amboinicus is widely regarded as having significant potential for clinical applications and warrants
further exploration, development, and exploitation through research. With this context, the present study
gathers information on the occurrence, biological description, cultivation, and nutritional values of Coleus amboinicus.
Furthermore, it thoroughly discusses various phytoconstituents, along with their classes, present in
Coleus amboinicus, followed by detailed descriptions of their pharmacological activities based on recent literature.
Biodistribution and Tumor Targeted Accumulation of Anti-CEA-loaded Iron Nanoparticles
Authors: Correa Thais Silva , Lima William Gustavo , do Couto Campos Aline Beatriz , Galdino Alexsandro Sobreira , de Oliveira Lima Emilia Celma , Cardoso Valbert Nascimento , Fernandes Simone Odília Antunes , Campos-da-Paz Mariana
Published: February 2024

Introduction:

Active targeting of tumors by nanomaterials favors early diagnosis and
the reduction of harsh side effects of chemotherapeuticals

Methods:

We synthesized magnetic nanoparticles (64 nm; -40 mV) suspended in a magnetic
fluid (MF) and decorated them with anti-carcinoembryonic antigen (MFCEA; 144 nm; -39 mV).
MF and MFCEA nanoparticles were successfully radiolabeled with technetium–99m (99mTc)
and intravenously injected in CEA-positive 4T1 tumor-bearing mice to perform biodistribution
studies. Both 99mTc-MF and 99mTc-MFCEA had marked uptake by the liver and spleen, and the
renal uptake of 99mTc-MFCEA was higher than that observed for 99mTc-MF at 20h. At 1 and 5
hours, the urinary excretion was higher for 99mTc-MF than for 99mTc-MFCEA.

Results:

These data suggest that anti-CEA decoration might be responsible for a delay in renal
clearance. Regarding the tumor, 99mTc-MFCEA showed tumor uptake nearly two times higher
than that observed for 99mTc-MFCEA. Similarly, the target-nontarget ratio was higher with
99mTc-MFCEA when compared to the group that received the 99mTc-MF.

Conclusion:

These data validated the ability of active tumor targeting by the as-developed anti-
CEA loaded nanoparticles and are very promising results for the future development of a
nanodevice for the management of breast cancer and other types of CEA-positive tumors.
Dauricine Inhibits Non-small Cell Lung Cancer Development by
Regulating PTEN/AKT/mTOR and Ras/MEK1/2/ERK1/2 Pathways in a
FLT4-dependent Manner
Authors: Liang Jinna , Lei Panpan , Su Xinyue , Gao Jiapan , Ren Bingxi , Zhang Yuxiu , Ma Xiaoyu , Ma Weina
Published: February 2024

Objective:

Non-small cell lung cancer (NSCLC) is still a solid tumor with high malignancy
and poor prognosis. Vascular endothelial growth factor receptor 3 (FLT4, VEGFR3) is
overexpressed in NSCLC cells, making it a potential target for NSCLC treatment. In this study, we
aimed to explore the anti-cancer effects of dauricine on NSCLC cells and its mechanism targeting
FLT4.

Methods:

We found that dauricine inhibited the growth of NCI-H1299 cells by blocking the cycle
in the G2/M phase through flow cytometry analysis. In addition, dauricine also inhibited the migration
of NCI-H1299 cells by wound healing assay and transwell migration assay. More importantly,
our empirical analysis found the anti-cancer effect of dauricine on NCI-H1299 cells and the protein
level of FLT4 had a distinctly positive correlation, and this effect was weakened after FLT4
knockdown.

Results:

It is suggested that dauricine suppressed the growth and migration of NCI-H1299 cells by
targeting FLT4. Furthermore, dauricine inhibited FLT4 downstream pathways, such as
PTEN/AKT/mTOR and Ras/MEK1/2/ERK1/2, thereby regulating cell migration-related molecule
MMP3 and cell cycle-related molecules (CDK1, pCDK1-T161, and cyclin B1).

Conclusion:

Dauricine may be a promising FLT4 inhibitor for the treatment of NSCLC.
Recent Progress on Photonic Cellulose Nanocrystal Films for Sensing Applications
Authors: Deng Zhijie , Tao Tao , Yuan Jianzhong , Wan Caichao
Published: February 2024

Cellulose nanocrystals (CNCs) have triggered considerable research interest in the
last few years owing to their unique optical, biodegradation, and mechanical behavior. Herein,
recent progress on the sensing application of photonic CNC films is summarized and discussed
based on the analyses of the latest studies. We briefly introduce the three approaches for preparing
CNCs: mechanical treatment, acid hydrolysis, and enzymatic hydrolysis, recapitulating
their differences in preparation and properties. Then, when the aqueous suspension of cellulose
nanocrystals (CNCs) reaches a specific concentration, it will self-assemble to form a lefthanded
nematic liquid crystal structure, and this structure can be maintained in films after
water evaporation, which has strong photonic crystal properties. The periodic layered structure
in the film interferes and diffracts with light, showing a rainbow color. Photonic CNC composites
that combine CNCs and functional materials have good properties and broad prospects.
Finally, we highlight the advanced applications of photonic CNC films, including mechanical
sensing, thermal sensing, and humidity sensing. The prospects and ongoing challenges of photonic
CNC films were summarized.
Antibacterial Potential of Tetrahydrocarbazoles (THCZ): A Review
Authors: Kumar Nitin , Sharma Shalini , Agrawal Saurabh , Verma Vishesh
Published: February 2024

:

Antibiotic resistance has become a major public threat across the globe associated with
human health. Some bacterial and fungal infections produce resistance, such as methicillinresistant
Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium (VRE)
and multidrug-resistant (MDR) species Acinetobacter baumannii etc. Tetrahydrocarbazoles
(THCz) are a sub-class of indole alkaloids profoundly present in natural products and biologically
active compounds and have displayed potential biological activities in literature. THCz exhibit
potential antibacterial activities through major bacterial pathways like cell wall synthesis inhibition
and DNA gyrase enzyme inhibition with DNA sliding clamp inhibitors and MreB inhibitors.
These THCZ also showed significant in vitro antibacterial activities against bacterial-resistant species,
such as MRSA, VRE and Acinetobacter baumannii (MDR) in literature. MTDL (Multi Target
Direct ligand) approach has been significantly used for the design of THC motif-based antibacterial
agents. In this review article, we collected literature on THCz as a potential antibacterial
agent from 2014 to date. The review study of THC core-based derivatives found excellent in vitro
antibacterial profiles and revealed that they can play a significant role in drug discovery and the
development of new antibiotics against various infectious diseases.
Quantitative Applications of ATR-FTIR Spectroscopy with Chemometrics
for the Estimation of Amikacin in Amikacin Sulphate Injections
Authors: Chen Chow Jie , Lokesh Bontha Venkata Subrahmanya , Akowuah Gabriel Akyirem
Published: February 2024

Background:

Amikacin belongs to the class of aminoglycoside antibiotics used in the
treatment of gram-negative bacterial infections. It is resistant to the aminoglycosides modifying enzymes,
making it a clinically effective drug in multidrug-resistant infections.

Methods:

In this study, a simple Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy
was used for the quantification of amikacin in amikacin sulphate injection. The infrared spectra
were generated in the spectral range of 4000–667 cm-1. The calibration curve was computed through
TQ Analyst Pro edition software, and the partial least square regression analysis found the linearity
in the range of 10-60% w/w.

Results:

The best calibration results were obtained in the spectral region from 1040 to 1020 cm-1
with a correlation coefficient (r2) of 1.000. The residual mean standard error (RMSEC) value was
0.00235. The percent relative standard deviation (%RSD) values for intra-day and inter-day precision
were less than 8.0. The percent relative error (%RE) values were calculated and found in between the
range of 0.52 to 5.60. The percent recovery of the amikacin estimation was 113.09 ± 4.27(n=3).

Conclusion:

This validated method is considered a green method, which is suitable for the routine
analysis of amikacin in amikacin sulphate injections.
Integrated Machine Learning Algorithms for Stratification of Patients with Bladder Cancer
Authors: He Yuanyuan , Wei Haodong , Liao Siqing , Ou Ruiming , Xiong Yuqiang , Zuo Yongchun , Yang Lei
Published: February 2024

Background:

Bladder cancer is a prevalent malignancy globally, characterized by rising
incidence and mortality rates. Stratifying bladder cancer patients into different subtypes is crucial for
the effective treatment of this form of cancer. Therefore, there is a need to develop a stratification
model specific to bladder cancer.

Purpose:

This study aims to establish a prognostic prediction model for bladder cancer, with the primary
goal of accurately predicting prognosis and treatment outcomes.

Methods:

We collected datasets from 10 bladder cancer samples sourced from the Gene Expression
Omnibus (GEO), the Cancer Genome Atlas (TCGA) databases, and IMvigor210 dataset. The machine
learning based algorithms were used to generate 96 models for establishing the risk score for each
patient. Based on the risk score, all the patients was classified into two different risk score groups.

Results:

The two groups of bladder cancer patients exhibited significant differences in prognosis,
biological functions, and drug sensitivity. Nomogram model demonstrated that the risk score had a
robust predictive effect with good clinical utility.

Conclusion:

The risk score constructed in this study can be utilized to predict the prognosis, response
to drug treatment, and immunotherapy of bladder cancer patients, providing assistance for personalized
clinical treatment of bladder cancer.
Anti-proliferative, Morphological and Molecular Docking Studies of New Thiophene
Derivatives and their Strategy in Ionic Liquids Immobilized Reactions
Authors: Mohareb Rafat M. , Mukhtar Sayeed , Parveen Humaira , Abdelaziz Mahmoud A. , Alwan Ensaf S.
Published: February 2024

Background:

A number of research were conducted on the pyran and thiophene derivatives, which
were attributed to have a wide range of biological activities, including anti-plasmodial, as well as acting as caspase, hepatitis C and cancer inhibitors.

Objective:

The multicomponent reactions of the 5-acetyl-2-amino-4-(phenylamino)-thiophene-3-carbonitrile
produced biologically active target molecules like pyran and their fused derivatives. Comparison between regular
catalytic multi-component reactions and solvent-free ionic liquids immobilized multicomponent was studied.

Methods:

The multicomponent reactions in this work were carried out not only under the reflux conditions using
triethylamine as a catalyst but also in solvent-free ionic liquids immobilized magnetic nanoparticles (MNPs)
catalysts.

Results:

Through this work, thirty-one new compounds were synthesized and characterized and were evaluated
toward the six cancer cell lines, namely A549, HT-29, MKN-45, U87MG, and SMMC-7721 and H460. The most
active compounds were further screened toward seventeen cancer cell lines classified according to the disease. In
addition, the effect of compound 11e on the A549 cell line was selected to make further morphological changes in
the cell line. The Molecular docking studies of 11e and 11f were carried and promising results were obtained.

Conclusion:

The synthesis of heterocyclic compounds derived from thiophene derivatives has been receiving
significant attention. After a detailed optimizing study, it has been found that the solvent-free ionic liquids immobilized multi-component syntheses afforded a high yield of compounds, opening a greener procedure for this
synthetically relevant transformation. Many of the synthesized compounds can be considered anticancer agents,
enhancing further studies
Advancements in the Research of GEF-H1: Biological Functions and Tumor
Associations
Authors: Li Liqi , Li Yunyun , Zhou Xiaoshu
Published: February 2024

Guanine nucleotide exchange factor H1 (GEF-H1) is a unique protein modulated by the GDP/GTP exchange. As a regulator of the Rho-GTPase
family, GEF-H1 can be activated through a microtubule-depended mechanism and phosphorylation regulation, enabling it to perform various
pivotal biological functions across multiple cellular activities. These include the regulation of Rho-GTPase, cytoskeleton formation, cellular
barrier, cell cycle, mitosis, cell differentiation, and vesicle trafficking. Recent studies have revealed its crucial effect on the tumor
microenvironment (TME) components, promoting tumor initiation and progress. Consequently, an in-depth exploration of GEF-H1’s biological
roles and association with tumors holds promise for its potential as a valuable molecular target in tumor treatment.
Barriers and Facilitators to Teledermatology and Tele-Eye Care in Department of Veterans Affairs Provider Settings: Qualitative Content Analysis
Authors: Li Yiwen , Pope Charlene , Damonte Jennifer , Spates Tanika , Maa April , Chen Suephy , Yeung Howa
Published: February 2024

Background

Veterans Affairs health care systems have been early adopters of asynchronous telemedicine to provide access to timely and high-quality specialty care services in primary care settings for veterans living in rural areas. Scant research has examined how to expand primary care team members’ engagement in telespecialty care.

Objective

This qualitative study aimed to explore implementation process barriers and facilitators to using asynchronous telespecialty care (teledermatology and tele-eye care services).

Methods

In total, 30 participants including primary care providers, nurses, telehealth clinical technicians, medical and program support assistants, and administrators from 2 community-based outpatient clinics were interviewed. Semistructured interviews were conducted using an interview guide, digitally recorded, and transcribed. Interview transcripts were analyzed using a qualitative content analysis summative approach. Two coders reviewed transcripts independently. Discrepancies were resolved by consensus discussion.

Results

In total, 3 themes were identified from participants’ experiences: positive perception of telespecialty care, concerns and challenges of implementation, and suggestions for service refinement. Participants voiced that the telemedicine visits saved commute and waiting times and provided veterans in rural areas more access to timely medical care. The mentioned concerns were technical challenges and equipment failure, staffing shortages to cover both in-person and telehealth visit needs, overbooked schedules leading to delayed referrals, the need for a more standardized operation protocol, and more hands-on training with formative feedback among supporting staff. Participants also faced challenges with appointment cancellations and struggled to find ways to efficiently manage both telehealth and in-person visits to streamline patient flow. Nonetheless, most participants feel motivated and confident in implementing telespecialty care going forward.

Conclusions

This study provided important insights into the positive perceptions and ongoing challenges in telespecialty care implementation. Feedback from primary care teams is needed to improve telespecialty care service delivery for rural veterans.
Table Correction: Effectiveness of eHealth Smoking Cessation Interventions: Systematic Review and Meta-Analysis (Preprint)
Authors: Fang Yichen E , Zhang Zhixian , Wang Ray , Yang Bolu , Chen Chen , Nisa Claudia , Tong Xin , Yan Lijing L
Published: February 2024

UNSTRUCTURED

In “Effectiveness of eHealth Smoking Cessation Interventions: Systematic Review and Meta-Analysis” (J Med Internet Res 2023;25:e45111) the authors noted three errors associated with the cited paper by Bricker et. al [1] in Table 5. In Table 5 row “Bricker et al” of the originally published manuscript, 1) the number of quits and smoking participants at 12-month follow-up in the intervention group was entered incorrectly as “12 months: 256” in “Intervention quit, n” column and “12 months: 856” in “Intervention smoking, n” column. The numbers have been replaced by “12 months: 356” in “Intervention quit, n” column and “12 months: 858” in “Intervention smoking, n”. This error then led to 2) the incorrect number of “12 months: 0.92 (0.79-1.06)” in the “RR 95% CI” column and 3) the incorrect statement of “No significant increase on cessation outcome at 12 months follow-ups; significant increase on cessation outcome at 3- and 6-month follow-ups” in the “Summary of outcome” column. The entry in column “RR 95% CI” has now been corrected to “12 months: RR=1.17 (95% CI: 1.02-1.33)” and the entry in column “summary of outcome” has now been corrected to “significant increase in cessation outcome at 3-, 6- and 12-month follow-ups”. The error did not affect any other part of the paper as the error happened during the final formatting stage on the authors’ end and the manuscript content was drafted with the correct numbers. The correction will appear in the online version of the paper on the JMIR Publications website on January 16, 2024, together with the publication of this correction notice. Because this was made after submission to PubMed, PubMed Central, and other full-text repositories, the corrected article has also been resubmitted to those repositories. Reference [1] Bricker JB, Watson NL, Mull KE, Sullivan BM, Heffner JL. Efficacy of smartphone applications for smoking cessation: a randomized clinical trial. JAMA Intern Med 2020 Nov 01;180(11):1472-1480
Presenting and Evaluating a Smartwatch-Based Intervention for Smoking Relapse (StopWatch): Feasibility and Acceptability Study (Preprint)
Authors: Stone Chris , Essery Rosie , Matthews Joe , Naughton Felix , Munafo Marcus , Attwood Angela , Skinner Andy
Published: February 2024

BACKGROUND

Despite the benefits of smoking cessation, maintaining abstinence during a quit attempt is difficult, and most attempts result in relapse. Innovative, evidence-based methods of preventing relapse are needed. We present a smartwatch-based relapse prevention system that uses passive detection of smoking to trigger just-in-time smoking cessation support.

OBJECTIVE

This study aims to evaluate the feasibility of hosting just-in-time smoking cessation support on a smartwatch and the acceptability of the “StopWatch” intervention on this platform.

METHODS

The person-based approach for intervention development was used to design the StopWatch smoking relapse prevention intervention. Intervention delivery was triggered by an algorithm identifying hand movements characteristic of smoking from the smartwatch’s motion sensors, and the system-generated intervention messages (co-designed by smokers) were delivered on the smartwatch screen. A total of 18 smokers tested the intervention over a 2-week period, and at the end of this period, they provided qualitative feedback on the acceptability of both the intervention and the smartwatch platform.

RESULTS

Participants reported that the smartwatch intervention increased their awareness of smoking and motivated them to quit. System-generated intervention messages were generally felt to be relevant and timely. There were some challenges with battery life that had implications for intervention adherence, and the bulkiness of the device and the notification style reduced some participants’ acceptability of the smartwatch platform.

CONCLUSIONS

Our findings indicate our smoking relapse prevention intervention and the use of a smartwatch as a platform to host a just-in-time behavior change intervention are both feasible and acceptable to most (12/18, 66%) participants as a relapse prevention intervention, but we identify some concerns around the physical limitations of the smartwatch device. In particular, the bulkiness of the device and the battery capacity present risks to adherence to the intervention and the potential for missed detections. We recommend that a longer-term efficacy trial be carried out as the next step.
Impact of a 3-months recall using high-fidelity simulation or serious game simulation on learning retention during neonatal resuscitation training in delivery room. (Preprint)
Authors: Michelet Daphne , Dopff Cécile , Loron Gauthier , Dopff Cécile
Published: February 2024

BACKGROUND

Retention capacities depends on the learning context. The optimal interval between two learning sessions to maintain the learner’s knowledge is often a subject of discussion, as well as the methodology used. Digital simulation could represent an easy alternative for re-training in neonatal resuscitation.

OBJECTIVE

The aim of the study was to evaluate the benefits of a 3-month recall in high-fidelity simulation or digital simulation after an initial high-fidelity neonatal resuscitation training in simulation among anesthesia and intensive care residents.

METHODS

All anesthesia and intensive care residents who participated were volunteers and they were trained in the same session (theoretical course and a high-fidelity simulation). Then, attendees were randomized in three groups: a first group with no 3-month recall, a second one with a high-fidelity simulation recall, and a last group with a digital simulation recall. In order to reassess the skills of each participant, a high-fidelity simulation has been performed at 6 months. The evaluation included some knowledge quiz on neonatal resuscitation, self-assessment of confidence, expert assessment of technical skills using the NRPE score, and non-technical skills assessed by the ANTS score. We compared the results between groups and intragroup progressions.

RESULTS

Twenty-eight participants were included in the study. No differences were observed between groups at the 6-month evaluation. However, we observed a significant improvement in theoretical knowledge and self-confidence among students over time. Concerning non-technical skills evaluated by the ANTS score, there was a significant improvement between the initial training and the session at 6 months in both groups that had a recall session. Regarding technical skills assessed by the NRPE score, there was a non-significant trend toward improvement in the two groups with recall, while a regression was observed in the control group. The increase of students' self-confidence was significant for each group, but it remained higher in the two groups that had a 3-month recall.

CONCLUSIONS

Initial training for anesthesia and intensive care residents in neonatal resuscitation leads to improved knowledge and self-confidence that persists at 6 months. A 3-month recall, whether through high-fidelity simulation or digital simulation, is showing better results on technical and non-technical skills (such as situation management and team communication). Digital simulation, while saving time and resources, seems to be an effective educational method for recall after initial training. The study’ outcomes are justifying the need of further studies, with larger attendance, to confirm the promising results of the serious games role in the educational programs for students.
Minimizing the Risk of Misprescribing GLP-1 RA Medications in a Digital Weight-Loss Service: Preliminary Retrospective Study (Preprint)
Authors: Talay Louis , Vickers Matt , Fuller Sarah
Published: February 2024

UNSTRUCTURED

A 6-month preliminary retrospective analysis of Australia's largest digital weight-loss service found that the company's clinicians commit prescribing errors in 2.2% of GLP-1 RA orders to weight-loss patients.
Traducción al español y análisis de confiabilidad del inventario de estilos de aprendizaje de Vermunt en residentes de pediatría
Authors: Gamboa-Salcedo Tamara , García-Durán Rocío , Peña-Alonso Yolanda Rocío
Published: February 2024

Introducción: “Estilo de aprendizaje” es la aplicación de un estilo cognitivo, en una situación de aprendizaje determinada. Resulta de la interacción temporal de influencias personales y del contexto. Su identificación resulta fundamental para optimizar el proceso de enseñanzaaprendizaje, pues se ha descrito la necesidad de que exista congruencia entre los estilos de enseñanza y aprendizaje. El Inventario de Estilos de Aprendizaje de Vermunt (IEAV) es una herramienta, que evalúa elementos que no han sido estudiados de manera conjunta. Actualmente no existe un instrumento con características similares, que pueda ser aplicado a la población de habla hispana, pues la mayoría de las herramientas para evaluar los estilos de aprendizaje han sido diseñadas para poblaciones anglosajonas.

Objetivo: Contar con una herramienta la cual posea evidencia de validez, para aplicar en nuestro medio.

Métodos: Para la traducción se siguió la metodología sugerida por Brislin. Se hizo una traducción inicial al español, la revisión gramatical de la versión traducida, una traducción inversa y finalmente, se cotejaron uno por uno los ítems tanto de la versión original como de la traducción inversa. El análisis estadístico fue tanto descriptivo como inferencial.

Resultados: Se obtuvo la versión en español de los 120 reactivos del inventario, el coeficiente α de Cronbach fue de 0.91.

Conclusiones: Las traducciones en diferentes idiomas presentan diferencias lingüísticas y culturales. La globalización educativa, permite el intercambio de herramientas que pueden traducirse y adaptarse al contexto de la población blanco. La traducción de un instrumento de medición, es un paso importante en el proceso de adopción de la herramienta a otra lengua y resulta fundamental, pues la calidad del instrumento traducido será directamente proporcional a la del proceso de traducción y su validación.
Educación médica basada en evidencias: ¿Ser o no ser?
Authors: Sánchez-Mendiola Melchor
Published: February 2024

Introducción: La práctica de la enseñanza en las ciencias de la salud, requiere incorporar el cuerpo de literatura científica disponible en educación y ciencias sociales. La Educación Médica Basada en Evidencias (EMBE) ha surgido como un movimiento, que propone utilizar la evidencia publicada para informar las decisiones y prácticas educativas, en las instituciones de salud académicas y las escuelas de medicina. Su diseminación e implementación han sido lentas por múltiples razones, es necesario reflexionar sobre sus avances y obstáculos en el escenario actual de la educación médica.Objetivo: Proveer una actualización y reflexión crítica sobre la EMBE.Método: Revisión narrativa de la literatura y ensayo crítico sobre el tema utilizando viñetas educativas. El análisis se estructuró de la siguiente manera: definición e historia de la EMBE, semejanzas y diferencias con la Medicina Basada en  videncias (MBE), y los retos y oportunidades actuales.Discusión: El uso de la evidencia publicada en las actividades del ser humano (como la medicina y la educación), está lleno de retos conceptuales y prácticos. Muchos profesionales basan sus decisiones y prácticas educativas principalmente en la experiencia, sin ser conscientes de los enormes avances en el campo de la educación y ciencias sociales ni tomar en cuenta la amplia literatura científica disponible para informar sus actividades de enseñanza y evaluación. Las escuelas de medicina y los hospitales deberían adquirir por lo menos el material profesional básico de educación en ciencias de la salud (libros, revistas, bases de datos), entrenar a sus educadores en la búsqueda de bases de datos sobre educación y en la evaluación crítica de artículos de las ciencias sociales, y promover colaboración interdisciplinaria con académicos de la educación y ciencias sociales entrenados formalmente.

Conclusiones: El enfoque de la EMBE para el desarrollo profesional de la práctica educativa debería integrarse en las iniciativas de mejoría de calidad en las escuelas de medicina e instituciones académicas de salud. La enseñanza reflexiva es esencial para el aprendizaje significativo en las profesiones de la salud.
Descripción y usos del método Delphi en investigaciones del área de la salud
Authors: Varela-Ruiz Margarita , Díaz-Bravo Laura , García Durán Rocío
Published: February 2024

El presente manuscrito aborda un panorama general de la técnica Delphi, desde su origen hasta las etapas que la integran para lograr la premisa de la misma: llegar a un consenso entre expertos. La dinámica de la técnica gira en torno a una problemática compleja, de ahí se derivan una serie de cuestionamientos que el grupo coordinador va guiando, analizando y supervisando a modo de hacer fluir la información entre el grupo de expertos y el mismo grupo coordinador. Dentro de este proceso surge oportunamente el feedback, elemento importante para lograr establecer un nivel de acuerdo entre los expertos. La técnica favorece la investigación en el área de las ciencias de la salud, pues una de las fortalezas que tiene es no requerir de la presencia de los expertos y la dinámica del manejo de la información se gestiona a través de correo postal o vía internet. En el caso de los expertos del área de las ciencias de la salud, quienes suelen ser de los profesionales con mayor saturación de agendas, por medio del uso de las tecnologías de la comunicación es posible contar con ellos para que formen parte del grupo y contribuyan con juicios y opiniones en pro de la investigación en esta área.
Elementos para el desarrollo de presentaciones académicas en PowerPoint
Authors: Flores-Hernández Fernando , Villamar-Chulín Joel
Published: February 2024

ResumenEl presente documento describe de manera sintética, la relevancia del uso y desarrollo de las presentaciones de tipo académico usando PowerPoint, y brinda una descripción de los principales elementos a considerar para su adecuado diseño, desarrollo y presentación.
Liderazgo en medicina: ¿debemos enseñarlo y evaluarlo?
Authors: Sánchez-Mendiola Melchor
Published: February 2024

Introducción: La enseñanza y práctica de las ciencias de la salud se ha convertido en una tarea cada vez más compleja, saturada de retos que requieren habilidades de liderazgo y cambio organizacional. En las últimas décadas la producción académica sobre liderazgo ha tenido una verdadera explosión, y se requiere que los docentes y educandos que viven la formación de recursos humanos sean conscientes de la necesidad de usar esta información en su desarrollo personal.

Objetivo: Proveer un panorama actualizado sobre el liderazgo en medicina y sus implicaciones educativas.

Método: Revisión narrativa de la literatura sobre el tema. Se analizaron los siguientes temas: relevancia del liderazgo en la práctica y enseñanza de la medicina; definición de liderazgo; liderazgo como rasgo vs. proceso; liderazgo asignado vs. emergente; administración vs. liderazgo; enseñanza de liderazgo en el continuo de la educación médica; reflexiones sobre su enseñanza y evaluación.

Discusión: La aplicación apropiada de los conceptos modernos de liderazgo puede ser determinante en los resultados educativos y clínicos de nuestros hospitales y universidades. Existe gran cantidad de literatura académica sobre el tema que puede informar a clínicos y docentes de ciencias de la salud, así como una cuantiosa disponibilidad de actividades educativas sobre el tema, presenciales y en línea. Dos ejemplos fundamentales de la aplicación de este concepto han ocurrido en Canadá y el Reino Unido. La mayoría de los estudios sobre el tema de liderazgo en medicina y en educación médica se han publicado en Norteamérica, es necesario que realicemos investigación original y desarrollo curricular sobre el tema en el contexto nacional y local, sin perder de vista la perspectiva global.

Conclusión: La competencia en liderazgo efectivo debe tomarse en cuenta en la planeación educativa de las escuelas e instituciones de ciencias de la salud.
Educational waqf (endowment) in artificial intelligence programs: Toward a new form of waqf
Authors: Agaileh Zaid Muhmoud
Published: February 2024

Waqf entails locking-up the title of an owned property and allotting the benefits for charitable purposes. It is among the most emphasized acts of righteousness in Islam, emphasizing social justice, collective good deeds, and fair distribution of wealth. The main legislation regulating and governing waqf in the United Arab Emirates (UAE) is the Federal Waqf Law No. 5 of 2018, largely derived from Islamic law (Shari’a). This study discusses the possible benefits of applying the waqf system in educational programs related to artificial intelligence (AI) in the Emirate of Dubai. It discusses the general legal rules of waqf in UAE law and its applications in the field of education, as well as its potential role in AI programs. It concludes that waqf can nowadays play a distinguished role in promoting investment in educational programs in Dubai, particularly with regard to AI. The present study paves the way for a better understanding of the role of waqf in the field of education and its results contribute to the growing literature on the subject.
Guest editorial: Innovations in intelligent systems and applications
Authors: Ivanovic Mirjana , Chbeir Richard , Manolopoulos Yannis
Published: February 2024

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Improved glycemic outcomes with diabetes technology use independent of socioeconomic status in youth with type 1 diabetes.
Authors: Lomax Kate E. , E Taplin Craig , Abraham Mary B. , Smith Grant J. , Haynes Aveni , Zomer Ella , L. Ellis Katrina , Clapin Helen , Zoungas. Sophia , Jenkins Alicia J. , Harrington Jennifer , de Bock Martin I , Jones Timothy W , Davis Elizabeth A.
Published: February 2024

Objective Technology use in type 1 diabetes (T1D) is impacted by socioeconomic status (SES). This analysis explored relationships between SES, glycemic outcomes and technology use. Research Design and Methods Cross-sectional analysis of HbA1c data from 2822 Australian youth with T1D was undertaken. Residential postcode was used to assign SES based on The Index of Relative Socio-Economic Disadvantage (IRSD). Linear regression models evaluated associations between IRSD quintile, HbA1c and management regimen. Results Insulin pump therapy, continuous glucose monitoring and their concurrent use were associated with lower mean HbA1c across all IRSD quintiles (p<0.001). There was no interaction between technology use and IRSD quintile on HbA1c (p=0.624), reflecting a similar association of lower HbA1c with technology use across all IRSD quintiles. Conclusions Technology use was associated with lower HbA1c across all socioeconomic backgrounds. Socioeconomic disadvantage does not preclude glycemic benefits of diabetes technologies, highlighting the need to remove barriers to technology access.
Sociodemographic and Environmental Determinants of Regional Prevalence of Psoriasis in Germany: A Spatiotemporal Study of Ambulatory Claims Data
Authors: Andrees Valerie , Wolf Sandra , Sander Marie , Augustin Matthias , Augustin Jobst
Published: February 2024

There are regional differences in the prevalence of psoriasis between countries, as well as within countries. However, regional determinants of differences in prevalence are not yet understood. The aim of this study was to identify sociodemographic and environmental determinants of regional prevalence rates for psoriasis. Analyses were based on German outpatient billing data from statutory health insurance, together with data from databases on sociodemographic and environment factors at the county level (N = 402) for 2015–2017. Descriptive statistics were calculated for all variables. To identify determinants for prevalence at the county level, spatiotemporal regression analysis was performed, with prevalence as the dependent variable, and the number of physicians, mean age, mean precipitation, sunshine hours, mean temperature, level of urbanity, and the German Index of Socioeconomic Deprivation (GISD) as independent variables. Mean prevalence of psoriasis increased from 168.63 per 10,000 in 2015 to 173.54 per 10,000 in 2017 for Germany as a whole, with high regional variation. Five determinants were detected (p < 0.05). The prevalence increased by 4.18 per 10,000 persons with SHI with each GISD unit, and by 3.76 per 10,000 with each year increase in age. Each additional hour of sunshine resulted in a decrease of 0.04 and each °C increase in mean temperature resulted in an increase of 4.22. Each additional dermatologist per 10,000 inhabitants resulted in a decrease of 0.07. In conclusion, sociodemographic and environmental factors result in significant differences in prevalence of psoriasis, even within-country.
Determination of plant growth promoting properties and bioremediation potentials of Bacillus mycoides Flügge and B. thuringiensis Berliner
Authors: Üreyen Esertaş Ülkü Zeynep , Bozdeveci Arif , Uzunalioğlu Emel , Alpay Karaoğlu Şengül
Published: February 2024

Industrial activities destroying natural resources for decades have been one of the most significant factors in environmental destruction. As a result of industrialization, environmental pollutants became one of the biggest threats for the biosphere. Heavy metals, one of these environmental pollutants, have become a significant health threat for organisms by forming metal accumulations in water and soil. In addition to the existing ones, most researchers believe that there is a great need for alternative biological processes to be used in the control of heavy metal pollution. Bioremediation is the process of removing various toxic pollutants, such as heavy metals from the environment, especially with the help of fungal and bacterial microorganisms, sometimes plants and earthworms. The use of bacteria in the bioremediation process is prevalent. In this study, the metal tolerance and plant growth-promoting properties of Bacillus mycoides and Bacillus thuringiensis isolated from the root soil of and orchid plant were investigated. The abilities of both bacteria to tolerate copper, lead, iron, silver, and zinc were tested in addition to and their indole acetic acid production (IAA), siderophore production, phosphate solubility and Aminocyclopropane-1-Carboxylate-deaminase (ACC-deaminase) activity were determined. The two isolates exhibited a high level of tolerance towards different pH levels, temperature ranges and metal concentrations. The results showed that B. mycoides and B. thuringiensis isolates can be used as bioremidant agents in metal-contaminated soils and also as biological fertilizers due to their plant growth-promoting properties.
Analysis of the current state of the developement in the area of secured routes (via ferratas) in Slovakia
Authors: Čech Vladimír , Javorská Miriama
Published: February 2024

Climbing on secured routes (via ferratas) represents a specific form of "hard" adventure tourism, for which the term "adrenaline tourism" is also used. The development of via ferratas construction in Slovakia can be dated back to the 21st century in comparison to the Alpine region where construction began in 1843. Eight authorized/legal via ferratas and several “unofficial” ones are known in Slovakia. Considering this relatively new form of tourism in Slovakia, it is possible to assume its dynamic development shortly. The limiting factors of their construction in Slovakia are the financial costs for the construction and maintenance and especially the requirements for nature protection under Act no. 543/2002 Coll. The paper analyses the current state of development of the existing via ferratas in Slovakia, their spatial distribution, comparison, and fundamental parameters. Also, it considers the potential of their future development. The work is the first study in this field in Slovakia, as a similar analysis has yet to be carried out.
Effects of diet on the bacterial and eukaryotic microbiota across the gastrointestinal tract of healthy rabbits (Oryctolagus cuniculus)
Authors: Rahic-Seggerman Faith M. , Rosenthal Karen , Miller Craig , Iske Cayla , Graham Jennifer , Schmitz-Esser Stephan , Kohles Micah R.
Published: February 2024

OBJECTIVE

This study aimed to characterize the bacterial and eukaryotic microbiota of the gastrointestinal (GI) tract in domestic rabbits and to evaluate the effect of different diet characteristics, such as pelleting, extrusion, and hay supplementation.

ANIMALS

30 New Zealand White rabbits (15 male and 15 female; 6 to 7 months old) were fed 1 of 6 diets (5 rabbits per diet) for 30 days after an initial acclimation period. At the end of the trial, samples were collected from the stomach, small intestine, cecum, large intestine, and hard feces.

METHODS

The samples were analyzed using 16S rRNA and internal transcribed spacer 1 region-targeted amplicon sequencing.

RESULTS

The bacterial microbiota was distinct between the foregut and hindgut. The most abundant bacterial genera included an unclassified genus in the Bacteroidales order and Alistipes. Candida was the most abundant genus in the eukaryotic dataset. In the bacterial dataset, diet No Hay/Pellet E was shown to have lower diversity (Shannon diversity, P < .05) compared to all diet groups except for No Hay/Pellet M. Few significant differences in alpha-diversity indexes between diet groups were detected in the eukaryotic dataset.

CLINICAL RELEVANCE

Our findings demonstrated that feeding hay had a significant effect on the beta diversity of the bacterial microbiota. Given the prevalence of gastrointestinal disease in the domestic rabbit population, furthering our understanding of what constitutes a healthy rabbit microbiota and the effects of different diets on the microbial community can help veterinarians implement better intervention strategies and allow pet owners to provide the best level of care.