bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of height and pubertal timing with lipoprotein subclass profile: Exploring the role of genetic and environmental effects
Authors: Jelenkovic Aline , Bogl Leonie H. , Rose Richard J. , Kangas Antti J. , Soininen Pasi , Ala‐Korpela Mika , Kaprio Jaakko , Silventoinen Karri
Published: May 2013

Objectives

Little is known about the relationship between growth and lipoprotein profile. We aimed to analyze common genetic and environmental factors in the association of height from late childhood to adulthood and pubertal timing with serum lipid and lipoprotein subclass profile.

Methods

A longitudinal cohort of Finnish twin pairs (FinnTwin12) was analyzed using self‐reported height at 11–12, 14, 17 years and measured stature at adult age (21–24 years). Data were available for 719 individual twins including 298 complete pairs. Serum lipids and lipoprotein subclasses were measured by proton nuclear magnetic resonance spectroscopy. Multivariate variance component models for twin data were fitted. Cholesky decomposition was used to partition the phenotypic covariation among traits into additive genetic and unique environmental correlations.

Results

In men, the strongest associations for both adult height and puberty were observed with total cholesterol, low‐density lipoprotein cholesterol, intermediate‐density lipoprotein cholesterol, and low‐density lipoprotein particle subclasses (max. r = −0.19). In women, the magnitude of the correlations was weaker (max. r = −0.13). Few associations were detected between height during adolescence and adult lipid profile. Early onset of puberty was related to an adverse lipid profile, but delayed pubertal development in girls was associated with an unfavorable profile, as well. All associations were mediated mainly by additive genetic factors, but unique environmental effects cannot be disregarded.

Conclusions

Early puberty and shorter adult height relate to higher concentrations of atherogenic lipids and lipoprotein particles in early adulthood. Common genetic effects behind these phenotypes substantially contribute to the observed associations. Am. J. Hum. Biol. 25:465–472, 2013. © 2013 Wiley Periodicals, Inc.
Xq25 duplications encompassing GRIA3 and STAG2 genes in two families convey recognizable X‐linked intellectual disability with distinctive facial appearance
Authors: Philippe Anne , Malan Valérie , Jacquemont Marie‐Line , Boddaert Nathalie , Bonnefont Jean‐Paul , Odent Sylvie , Munnich Arnold , Colleaux Laurence , Cormier‐Daire Valérie
Published: May 2013

We report here on two patients with Xq25 duplication encompassing GRIA3 gene, encoding glutamate receptor, ionotropic, AMPA subunit 3. The first case of Xq25 duplication was identified using genome‐wide array comparative genomic hybridization (array‐CGH) in a 24‐year‐old patient with syndromic intellectual disability. Based on similar facial features, we clinically suspected a second case of Xq25 duplication in a 4‐year‐old boy with intellectual disabilty. This duplication was confirmed by multiplex ligation‐dependent probe amplification (MLPA) of the GRIA3 gene, as well as by fluorescence in situ hybridization (FISH) and further refined by array‐CGH. We suggest that Xq25 duplication is responsible for a novel clinically recognizable X‐linked intellectual disability. Finally, the review of so far published Xq25 duplications support, in addition to the role of GRIA3 gene, a potential contribution of the duplication of STAG2 (Stromal Antigen 2) gene coding for the subunit SA1 of the cohesin complex in the clinical phenotype. © 2012 Wiley Periodicals, Inc.
Sleep disturbance as part of the neurofibromatosis type 1 phenotype in adults
Authors: Leschziner Guy D. , Golding John F. , Ferner Rosalie E.
Published: May 2013

Neurofibromatosis type 1 (NF1) is an autosomal dominant condition with a wide array of neurological complications, including cognitive dysfunction, tumors, malformations, neuropathy, neurovascular disease, and epilepsy. Many of these complications may impact on sleep quality and cause sleep disturbance. Previously sleep disturbance in NF1 has been specifically addressed solely in children. We performed a prospective study of sleep quality in 114 consecutive out‐patients with NF1 attending our national neurofibromatosis service. The Epworth sleepiness scale (ESS) and the Pittsburgh sleep quality index (PSQI) were administered, and information was obtained from patient records on drugs potentially impacting on sleep, complications directly affecting sleep and employment status. The mean ESS was 6.8, and 21% had an abnormally high ESS of 10 or more. The mean global PSQI score was 8.4 (norm mean 2.67), with abnormally high scores in all sleep domains. Thirty‐nine patients had a bed partner and 54% reported features suggestive of periodic limb movements of sleep, 43% had features suggestive of obstructive sleep apnoea, and 10.8% experienced confusion on waking. There was no evidence of phase shift. The ESS did not correlate with the PSQI, but unemployment status was associated with worse global PSQI score and multiple domain sub‐scales of sleep quality in the PSQI. We conclude that sleep disturbance and poor sleep quality are significantly more frequent in the adult NF1 patient population. It is likely to be multi‐factorial, related to pain, anxiety, depression, cognitive issues, and organic sleep pathology. We recommend careful assessment of patients to determine underlying triggers and possible treatment strategies. © 2013 Wiley Periodicals, Inc.
Diagnostic screening identifies a wide range of mutations involving the SHOX gene, including a common 47.5 kb deletion 160 kb downstream with a variable phenotypic effect
Authors: Bunyan David J. , Baker Kevin R. , Harvey John F. , Thomas N. Simon
Published: May 2013

Léri–Weill dyschondrosteosis (LWD) results from heterozygous mutations of the SHOX gene, with homozygosity or compound heterozygosity resulting in the more severe form, Langer mesomelic dysplasia (LMD). These mutations typically take the form of whole or partial gene deletions, point mutations within the coding sequence, or large (>100 kb) 3′ deletions of downstream regulatory elements. We have analyzed the coding sequence of the SHOX gene and its downstream regulatory regions in a cohort of 377 individuals referred with symptoms of LWD, LMD or short stature. A causative mutation was identified in 68% of the probands with LWD or LMD (91/134). In addition, a 47.5 kb deletion was found 160 kb downstream of the SHOX gene in 17 of the 377 patients (12% of the LWD referrals, 4.5% of all referrals). In 14 of these 17 patients, this was the only potentially causative abnormality detected (13 had symptoms consistent with LWD and one had short stature only), but the other three 47.5 kb deletions were found in patients with an additional causative SHOX mutation (with symptoms of LWD rather than LMD). Parental samples were available on 14/17 of these families, and analysis of these showed a more variable phenotype ranging from apparently unaffected to LWD. Breakpoint sequence analysis has shown that the 47.5 kb deletion is identical in all 17 patients, most likely due to an ancient founder mutation rather than recurrence. This deletion was not seen in 471 normal controls (P < 0.0001), providing further evidence for a phenotypic effect, albeit one with variable penetration. © 2013 Wiley Periodicals, Inc.
Oculoauriculofrontonasal syndrome: Case series revealing new bony nasal anomalies in an old syndrome
Authors: Evans Kelly N. , Gruss Joseph S. , Khanna Paritosh C. , Cunningham Michael L. , Cox Timothy C. , Hing Anne V.
Published: May 2013

Frontonasal Dysplasia (FND) and Oculo‐auriculo‐vertebral spectrum (OAVS) are two well‐recognized clinical entities. With features of both FND and OAVS, the term oculoauriculofrontonasal syndrome (OAFNS) was coined in 1981. The OAFNS phenotype combines elements of abnormal morphogenesis of the frontonasal and maxillary process (derived from forebrain neural crest) with abnormal development of the first and second branchial arches (derived from hindbrain neural crest). We present a case series of 33 children with OAFNS ascertained from a comprehensive review of the literature and report an additional retrospective series of eight patients displaying features consistent with OAFNS. Notably, in a subset of our cases, we have observed abnormalities in nasal ossification and bony structures of the maxilla that have not previously described in OAFNS and are not seen in either FND or OAVS. We present the phenotype and novel naso‐maxillary findings and explore potential etiologic and developmental pathways for OAFNS. We highlight the differences in phenotypic characteristics of OAFNS compared to OAVS and FND. These observations support the classification of OAFNS as a discrete syndrome. Further phenotypic refinements of OAFNS are needed to understand pathogenesis of this syndrome and the newly described nasal malformation may help identify the etiology. © 2013 Wiley Periodicals, Inc.
Characterization of B‐cell subpopulations in patients with chronic rhinosinusitis
Authors: Psaltis Alkis J. , Schlosser Rodney J. , Yawn James R. , Henriquez Oswaldo , Mulligan Jennifer K.
Published: May 2013

Background

Recent research suggest that B and plasma cells may play an important role in the pathogenesis of chronic rhinosinusitis with nasal polyposis (CRSwNP). The purpose of this study was to subcharacterize the B cell response in the sinus mucosa of control and CRS patients.

Methods

Representative tissue samples and peripheral blood samples were obtained from controls, CRS without nasal polyps (CRSsNP) and CRSwNP. Using single‐cell suspension flow cytometry these samples were analyzed for overall and stage‐specific B and plasma cell percentages.

Results

Both atopic and nonatopic CRSwNP patients showed an increase in local numbers of naive, active, and memory B cells compared to controls. CRSsNP patients only showed local elevations of naive B cells. Plasma cells were only significantly elevated in the sinus tissue of atopic CRSwNP patients. These local tissue increases did not correlate with increased numbers of circulating B cells.

Conclusion

This study provides further evidence of an important role of B cells in CRSwNP patients. The local increase appears to be independent of a systemic response.
Synthesis and Characterization of Sulfated Gal‐β‐1,3/4‐GlcNAc Disaccharides through Consecutive Protection/Glycosylation Steps
Authors: Tu Zhijay , Hsieh Hsiao‐Wu , Tsai Chih‐Ming , Hsu Chia‐Wei , Wang Shy‐Guey , Wu Kuan‐Jung , Lin Kuo‐I , Lin Chun‐Hung
Published: May 2013

We have developed an expeditious procedure to yield large amounts of orthogonally protected Gal‐β1,3/4‐GlcNAc, which allowed for the systematic introduction of a sulfate group onto the C3/C6 positions of Gal and/or the C6 position of GlcNAc. In particular, the disaccharide precursors were prepared in five or six steps and high overall yield from para‐tolyl‐6‐O‐tert‐butyldiphenylsilyl‐1‐thio‐β‐D‐galactopyranoside. After deprotection and sulfation steps, the final products were characterized by using several NMR methods to unambiguously confirm the location of each introduced sulfate group and they were examined for their binding specificity of human galectin‐1 and galectin‐8.
Verbindungen von Fertigteilen aus UHPC
Authors: Schoening Janna , della Pietra Regina , Hegger Josef , Tue Nguyen Viet
Published: May 2013

Bauteile aus ultrahochfestem Beton (UHPC) werden insbesondere in Fertigteilwerken hergestellt. Daher sind tragfähige und wirtschaftliche Verbindungen von UHPC‐Fertigteilen von besonderer Bedeutung. In Verbindungen von Bauteilen können Schub‐, Druck‐ oder Zugkräfte oder Kombinationen aus diesen Belastungen auftreten. In dem vorliegenden Beitrag werden die im Rahmen des Schwerpunktprogramms 1182 “Nachhaltiges Bauen mit ultrahochfestem Beton” der Deutschen Forschungsgemeinschaft (DFG) durchgeführten Versuche zur Ermittlung der Tragfähigkeit wesentlicher Knotenpunkte von Fertigteilen beschrieben und die Ergebnisse diskutiert. Die Versuchsergebnisse dienen der Entwicklung von Ingenieurmodellen zur Bemessung von Fertigteilverbindungen aus UHPC.

Connections of precast UHPC elements

Ultra‐High Performance Concrete (UHPC) elements are particularly suited for precast construction. To utilise the high structural performance of single UHPC elements, solid and economical connections are essential. Such joints are exposed to shear, compressive or tensile forces or combinations of these. This paper presents tests on the load bearing capacity of UHPC nodes. All tests have been carried out within the priority programme 1182 “Sustainable Construction with UHPC” of the German Research Foundation (DFG). The test results provide a basis for construction recommendations of connections for precast UHPC elements.
Correction: Simultaneous confidence regions for closed tests, including Holm‐, Hochberg‐, and Hommel‐related procedures
Authors: Guilbaud Olivier J. M.
Published: May 2013

Algorithm 1 in Guilbaud (2012, p. 327) in Biometrical Journal (DOI: 10.1002/bimj.201100123) reproduced a recently detected index error in a theorem concerning a shortcut for rejection decisions for certain multiple‐testing procedures as it was stated in Bernhard et al. (2004, p. 8) in Statistical Papers (DOI: 10.1007/BF02778266). This short article provides: (i) the correction to be made to Algorithm 1 and (ii) a brief discussion of the consequences. Although the theoretical developments in Guilbaud (2012) are not affected, the numerical illustrations in Section 7 are affected. A corrected version of that section is given in the Supporting Information.
A survey of educational uses of molecular visualization freeware
Authors: Craig Paul A. , Michel Lea Vacca , Bateman Robert C.
Published: May 2013

As biochemists, one of our most captivating teaching tools is the use of molecular visualization. It is a compelling medium that can be used to communicate structural information much more effectively with interactive animations than with static figures. We have conducted a survey to begin a systematic evaluation of the current classroom usage of molecular visualization. Participants (n = 116) were asked to complete 11 multiple choice and 3 open ended questions. To provide more depth to these results, interviews were conducted with 12 of the participants. Many common themes arose in the survey and the interviews: a shared passion for the use of molecular visualization in teaching, broad diversity in software preference, the lack of uniform standards for assessment, a desire for more quality resources, and the challenge of enabling students to incorporate visualization in their learning. The majority of respondents had used molecular visualization for more than 5 years and mentioned 32 different visualization tools used, with Jmol and PyMOL clearly standing out as the most frequently used programs at the present time. The most common uses of molecular visualization in teaching were lecture and lab illustrations, followed by exam questions, in‐class or in‐laboratory exercises, and student projects, which frequently included presentations. While a minority of instructors used a grading rubric/scoring matrix for assessment of student learning with molecular visualization, many expressed a desire for common use assessment tools. © 2013 by The International Union of Biochemistry and Molecular Biology, 41(3):193–205, 2013
ChemInform Abstract: Structures of Uncharacterized Polymorphs of Gallium Oxide from Total Neutron Diffraction.
Authors: Playford Helen Y. , Hannon Alex C. , Barney Emma R. , Walton Richard I.
Published: May 2013

Polymorphs of Ga2O3 are characterized by powder neutron diffraction.
ChemInform Abstract: Lithium‐Stuffed Diamond Polytype Zn—Tt Structures (Tt: Sn, Ge): The Two Lithium—Zinc—Tetrelides Li3Zn2Sn4 and Li2ZnGe3.
Authors: Stegmaier Saskia , Faessler Thomas F.
Published: May 2013

In view of the search for alternative Li ion anode materials and electron‐poor framework semiconductors for thermoelectric applications, Li3Zn2Sn4 and Li2ZnGe3 are obtained by solid state reaction of a stoichiometric mixture of the elements (Ta ampule in an evacuated silica tube, 500 °C and 700 °C for the Ge and Sn tetrelides, resp., 5 d).
ChemInform Abstract: Tunable Color of Ce3+/Tb3+/Mn2+‐Coactivated CaScAlSiO6 via Energy Transfer: A Single‐Component Red/White‐Emitting Phosphor.
Authors: Lue Wei , Guo Ning , Jia Yongchao , Zhao Qi , Lv Wenzhen , Jiao Mengmeng , Shao Baiqi , You Hongpeng
Published: May 2013

A series of single‐component red/white‐emitting Ce3+,Tb3+,Mn2+‐doped CaScAlSiO6 phosphors are synthesized by solid state reaction of CaCO3, Sc2O3, SiO2, Al2O3, CeO2, Tb4O7, and MnCO3 (10% H2/N2, 1400 °C, 4 h).
ChemInform Abstract: Structural and Catalytic Properties of a Novel Vanadium Containing Solid Core Mesoporous Silica Shell Catalysts for Gas Phase Oxidation Reaction.
Authors: Venkatathri N. , Pillai Vijayamohanan K. , Rajini A. , Raju M. Nooka , Reddy I. A. K.
Published: May 2013

The title catalyst for diphenyl methane gas phase oxidation is synthesized by a sol—gel method from mixtures of V2O5, Si(OEt)4, octadecyltrichlorosilane, NEt3, acetone, and water (calcination at 823 K, 8 h).
ChemInform Abstract: Copper Oxide Nanostructures: Controlled Synthesis and Their Catalytic Performance.
Authors: Wang Hong‐yun , Fan Chuan‐Gang
Published: May 2013

CuO nanospheres, nanorods, oval nanoplatelets, and nanobundles are obtained by a template‐ and surfactant‐free hydrothermal synthesis using Cu(OAc)2·H2O and NaOH in molar ratios of 1:0, 1:1, 1:2, and 1:3 (autoclave, 100 °C, 6 h).
ChemInform Abstract: Gallium Analogue of Soluble Prussian Blue KGa[Fe(CN)6]·nH2O: Synthesis, Characterization, and Potential Biomedical Applications.
Authors: Kandanapitiye Murthi S. , Valley Benjamin , Yang Liu D. , Fry Allyson M. , Woodward Patrick M. , Huang Songping D.
Published: May 2013

KGa[Fe(CN)6]·nH2O is synthesized by mixing equimolar aqueous solutions of Ga(NO3)3 and K4[Fe(CN)6].
ChemInform Abstract: Reaction of ω‐Nitrostyrene with Diethyl Malonate in the Presence of Chiral Nickel(II) Complexes.
Authors: Reznikov A. N. , Klimochkin Yu. N.
Published: May 2013

Chiral Ni‐complexes (I)—(III) are prepared from the known ligands and nickel(II)chloride hexahydrate in boiling MeCN.
ChemInform Abstract: Chemo‐Enzymatic Reaction Sequence for the Synthesis of Dihydroxyacetone Phosphate (DHAP) Stock Material.
Authors: Karmee Sanjib Kumar
Published: May 2013

Glycerol is converted to the protected dihydroxy acetone precursor (XI) via a seven‐step chemo‐enzymatic methodology.
ChemInform Abstract: One‐Pot Cross Double‐Mannich Reaction of Acetaldehyde Catalyzed by a Binaphthyl‐Based Amino Sulfonamide.
Authors: Kano Taichi , Sakamoto Ryu , Yamaguchi Yukako , Itoh Ken‐ichi , Maruoka Keiji
Published: May 2013

Densely functionalized diamines having three contiguous stereocenters are synthesized in a stereoselective fashion in a one‐pot cross double‐Mannich reaction.
ChemInform Abstract: Solvent‐Free Diels—Alder Reaction in a Closed Batch System.
Authors: Sun Daolai , Sato Fumiya , Yamada Yasuhiro , Sato Satoshi
Published: May 2013

Solventless Diels—Alder reactions between volatile dienes and several dienophiles are studied in a closed batch reactor under pressurized conditions and without using any catalyst.
ChemInform Abstract: Ring Expansion and Rearrangements of Rhodium(II) Azavinyl Carbenes.
Authors: Selander Nicklas , Worrell Brady T. , Fokin Valery V.
Published: May 2013

A selective, rapid, scalable, simple synthesis of enaminones and olefins by ring expansion and rearrangement reactions is presented.
ChemInform Abstract: Asymmetric Synthesis of Diverse Glycolic Acid Scaffolds via Dynamic Kinetic Resolution of α‐Keto Esters.
Authors: Steward Kimberly M. , Corbett Michael T. , Goodman C. Guy , Johnson Jeffrey S.
Published: May 2013

This publication describes several enantioselective methods for the functionalization of α‐ketoesters with ruthenium asymmetric transfer hydrogenation catalysts via dynamic kinetic resolution, including the syntheses of γ‐lactones and α‐hydroxy‐β‐chloroesters.
ChemInform Abstract: Sustainable Synthesis of Diverse Privileged Heterocycles by Palladium‐Catalyzed Aerobic Oxidative Isocyanide Insertion.
Authors: Vlaar Tjoestil , Cioc Razvan C. , Mampuys Pieter , Maes Bert U. W. , Orru Romano V. A. , Ruijter Eelco
Published: May 2013

The novel and scalable title synthesis of a wide variety of pharmaceutically relevant heterocyclic systems, which is demonstrated for the intermediate (XXII) of astemizole and norastemizole, is presented by using an easily handled and relatively low‐cost catalyst.
ChemInform Abstract: Enantioselective Organocatalytic Michael Addition of Cyclobutanones to Nitroalkenes.
Authors: Mailhol Damien , del Mar Sanchez Duque Maria , Raimondi Wilfried , Bonne Damien , Constantieux Thierry , Coquerel Yoann , Rodriguez Jean
Published: May 2013

The organocatalytic, stereoselective Michael‐addition of nitroalkenes to functionalized cyclobutanones is presented.
ChemInform Abstract: An Efficient Organocatalytic Enantioselective Synthesis of Spironitrocyclopropanes
Authors: Das Utpal , Tsai Yi‐Ling , Lin Wenwei
Published: May 2013

starting from 2‐arylidene‐1,3‐indanediones (I) and corresponding bromonitroalkanes
ChemInform Abstract: 2‐Aryl‐2‐nitroacetates as Central Precursors to Aryl Nitromethanes, α‐Ketoesters, and α‐Amino Acids.
Authors: Metz Alison E. , Kozlowski Marisa C.
Published: May 2013

Conditions for selective transformations of the valuable title precursors are developed to obtain the desired products in good isolated yields.
ChemInform Abstract: An Efficient Catalytic Method for Regioselective Sulfenylation of Electron‐Rich Aza‐Aromatics at Room Temperature.
Authors: Marcantoni Enrico , Cipolletti Roberto , Marsili Laura , Menichetti Stefano , Properzi Roberta , Viglianisi Caterina
Published: May 2013

This reaction proceeds with high regioselectivity to yield sulfenyl‐substituted indole and pyrrole derivatives.
ChemInform Abstract: Addition of Thiols to o‐Quinone Methide: New 2‐Hydroxy‐3‐phenylsulfanylmethyl [1,4]Naphthoquinones and Their Activity Against the Human Malaria Parasite Plasmodium falciparum (3D7).
Authors: Sharma Abhinay , Santos Isabela O. , Gaur Pratibha , Ferreira Vitor F. , Garcia Celia R. S. , da Rocha David R.
Published: May 2013

None of the investigated compounds (III) exhibit better performance than respected control drugs.
ChemInform Abstract: An Air‐Stable Copper Reagent for Nucleophilic Trifluoromethylthiolation of Aryl Halides.
Authors: Weng Zhiqiang , He Weiming , Chen Chaohuang , Lee Richmond , Tan Davin , Lai Zhiping , Kong Dedao , Yuan Yaofeng , Huang Kuo‐Wei
Published: May 2013

This article describes readily available copper trifluoromethylthiolate complexes, which react with a wide range of aryl and heteroaryl halides to give the respective trifluoromethyl thioethers in good yields.
ChemInform Abstract: Synthesis of Polyphenyls.
Authors: Chang Meng‐Yang , Lee Tein‐Wei , Lin Shin‐Ying
Published: May 2013

The combination of regioselective bromination followed by Suzuki—Miyaura coupling reaction provides access to various polyphenyls, such as terphenyl, quaterphenyl, quinquephenyl, and sexiphenyl skeletons.
ChemInform Abstract: A Simple and Efficient Reusable Polystyrene‐Supported Palladium Catalyst for Hiyama Cross‐Coupling.
Authors: Diebold Carine , Derible Antoine , Becht Jean‐Michel , Le Drian Claude
Published: May 2013

An efficient synthesis of various biaryls (III) by Hiyama reaction between aryl iodides and aryltrialkoxysilanes is presented.
ChemInform Abstract: Direct Aza‐Darzens Aziridination of N‐Tosylimines with 2‐Bromomalonates for the Synthesis of Highly Functionalized Donor—Acceptor Aziridines.
Authors: Wu Xingxing , Li Lei , Zhang Junliang
Published: May 2013

The wide substrate scope, excellent yield, simple operating and purification procedures are advantages of the described method.
ChemInform Abstract: Ruthenium‐Catalyzed Pyrrole Synthesis via Oxidative Annulation of Enamides and Alkynes.
Authors: Li Bin , Wang Nuancheng , Liang Yujie , Xu Shansheng , Wang Baiquan
Published: May 2013

The title reaction affords either N‐acetyl‐substituted or N‐unsubstituted pyrrole derivatives in dependancy on conditions used.
ChemInform Abstract: Thiourea‐Catalyzed Asymmetric Conjugate Addition of α‐Substituted Cyanoacetates to Maleimides.
Authors: Ma Zhi‐wei , Wu Ya , Sun Bin , Du Hai‐long , Shi Wei‐min , Tao Jing‐chao
Published: May 2013

Enantiopure isosteviol‐derived tertiary amine‐thiourea (THI) is proven to be effective in catalyzing the asymmetric conjugate addition between α‐substituted cyanoacetates (I) and maleimides (II).
ChemInform Abstract: Phosphonite Mediated 1,3‐Dipolar Cycloaddition: A Route to Polycyclic 2‐Pyrrolines from Imines, Acid Chlorides and Alkenes.
Authors: Morin Marie S. T. , Aly Sara , Arndtsen Bruce A.
Published: May 2013

An efficient two‐step procedure is elaborated for the preparation of tricyclic cis‐pyrrolines (III) from imines (I) and acyl chlorides.
ChemInform Abstract: Convenient Synthesis of Highly Substituted Imidazole Derivatives
Authors: Wong Lai Chun , Gehre Alexander , Stanforth Stephan P. , Tarbit Brian
Published: May 2013

from α‐acetoxy‐α‐chloro‐‐keto‐esters (I)
ChemInform Abstract: Design, Synthesis, and Anticonvulsant Activity Evaluation of 4‐(3‐Alkoxy‐phenyl)‐2,4‐dihydro‐[1,2,4]triazol‐3‐ones.
Authors: Shu Bing , Zheng Yan , Wang Shi‐Ben , Deng Xian‐Qing , Quan Zhe‐Shan
Published: May 2013

Title compounds (IV) (20 examples) are synthesized and evaluated in vivo for their anticonvulsant activity and neurotoxicity.
ChemInform Abstract: Electrochemical Synthesis of 2‐Amino‐5‐substituted‐1,3,4‐oxadiazole Derivatives and Evaluation of Antibacterial Activity.
Authors: Kumar Sanjeev , Pandey H. N.
Published: May 2013

All the novel oxadiazole derivatives (II) (14 examples) exhibit significant antibacterial activity.
ChemInform Abstract: Green One‐Pot Synthesis of 2H‐Pyrans under Solvent‐Free Conditions Catalyzed by Ethylenediammonium Diacetate.
Authors: Riveira Martin J. , Mischne Mirta P.
Published: May 2013

A highly efficient and practical one‐pot procedure for the preparation of various 2H‐pyran derivatives using a Knoevenagel‐type condensation between 1,3‐dicarbonyl compounds with α,β‐unsaturated aldehydes under solvent‐free conditions is presented.
ChemInform Abstract: A Telescoped Route to 2,6‐Disubstituted 2,3,4,5‐Tetrahydropyridines and 2,6‐syn‐Disubstituted Piperidines: Total Synthesis of (—)‐Grandisine G.
Authors: Cuthbertson James D. , Taylor Richard J. K.
Published: May 2013

The value of this method is exemplified by the first total synthesis of (‐)‐grandisine G (XIII).
ChemInform Abstract: Microwave‐Assisted and Iodine‐Catalyzed Synthesis of Dihydropyrimidin‐2‐thiones via Biginelli Reaction under Solvent‐Free Conditions.
Authors: Liu Qingjian , Pan Ning , Xu Jiehua , Zhang Wenwen , Kong Fanpeng
Published: May 2013

41 Title compounds are prepared by a iodine‐catalyzed Biginelli reaction under microwave irradiation.
ChemInform Abstract: Pyrano[4,3‐d]pyrimidinium Salts. Part 5. Synthesis of 7‐Aryl‐1,3‐dimethyl‐2,4‐dioxo‐1H,3H‐pyrano[4,3‐d]pyrimidinium Salts and Their Reactions with Nucleophiles.
Authors: Gavrilenko I. A. , Kostrub V. V. , Tsupak E. B.
Published: May 2013

In the reaction with N‐nucleophiles, title compounds (II) undergo recyclization of the pyrylium ring to form compounds (III), (V), or (VI), resp., whereas the addition of C‐ and O‐nucleophiles occurs at the free position 5 of the system to form derivatives (VII), (IX), or (XI), respectively.
ChemInform Abstract: Facile One‐Pot Synthesis of 8H‐Quinazolino[4,3‐b]quinazolin‐8‐ones.
Authors: Venkateswarlu Somepalli , Satyanarayana Meka , Siddaiah Vidavalur
Published: May 2013

The first general, one‐pot procedure for the synthesis of quinazolinoquinazolinones (IV) is described.
ChemInform Abstract: Synthesis and Anticonvulsant Activity Evaluation of 5‐Phenyl‐[1,2,4]triazolo[4,3‐c]quinazolin‐3‐amines.
Authors: Zheng Yan , Bian Ming , Deng Xian‐Qing , Wang Shi‐Ben , Quan Zhe‐Shan
Published: May 2013

Starting from hydrazones (I), several triazoloquinazoline derivatives are prepared and evaluated in vivo for their anticonvulsant activity and neurotoxicity.
ChemInform Abstract: Novel One‐Pot Synthesis of Aziridines Carrying Sydnone Moiety and Their Biological Studies.
Authors: Hegde Jyothi C. , Girish K. S. , Adhikari Adithya , Kalluraya Balakrishna
Published: May 2013

Compounds (IIIb), (IIIc) and (IIIh) show considerable antibacterial and antifungal activities.
ChemInform Abstract: Catalytic Asymmetric Synthesis of Substituted Morpholines and Piperazines.
Authors: Zhai Huimin , Borzenko Andrey , Lau Ying Yin , Ahn Shin Hye , Schafer Laurel L.
Published: May 2013

Strategies are detailed for the preparation of 3‐substituted morpholines and 2,5‐disubstituted piperazines involving a hydroamination with N,O‐chelated Ti catalyst as key step.
ChemInform Abstract: Design and Synthesis of Novel 2‐Methyl‐4,5‐substitutedbenzo[f]‐3,3a,4,5‐tetrahydro‐pyrazolo[1,5‐d] [1,4]oxazepin‐8(7H)‐one Derivatives (II) as Telomerase Inhibitors.
Authors: Liu Xin‐Hua , Jia Ying‐Ming , Song Bao‐An , Pang Zhi‐Xiang , Yang Song
Published: May 2013

Compound (IIe) exhibits the most potent inhibitory activity against telomerase.
ChemInform Abstract: Mild Rh(III)‐Catalyzed C—H Activation and Annulation with Alkyne MIDA Boronates: Short, Efficient Synthesis of Heterocyclic Boronic Acid Derivatives.
Authors: Wang Honggen , Grohmann Christoph , Nimphius Corinna , Glorius Frank
Published: May 2013

The synthesized boron‐substituted heterocycles are useful for further transformations, e.
ChemInform Abstract: Synthesis and Antibacterial Evaluation of a Novel Tricyclic Oxaborole‐Fused Fluoroquinolone.
Authors: Li Xianfeng , et al. et al.
Published: May 2013

The first example of an oxaborole‐fused quinolone is synthesized starting from ciprofloxacin (I).
ChemInform Abstract: Diastereo‐ and Enantioselective Asymmetric Hydrogenation of α‐Amido‐β‐keto Phosphonates via Dynamic Kinetic Resolution.
Authors: Tao Xiaoming , Li Wanfang , Li Xiaoming , Xie Xiaomin , Zhang Zhaoguo
Published: May 2013

The presence of CeCl3·7H2O as a co‐catalyst is crucial to achieve excellent dia‐ and enantioselectivities predominantly.
ChemInform Abstract: Quinine‐Thiourea Catalyzed Enantioselective Hydrophosphonylation of Trifluoromethyl 2(1H)‐Quinazolinones.
Authors: Xie Hexin , Song Aiguo , Zhang Xinshuai , Chen Xiaobei , Li Hao , Sheng Chunquan , Wang Wei
Published: May 2013

Enantioenriched α‐aminophosphate analogues (III) of the non‐nucleoside reverse transcriptase inhibitor DPC‐083 are readily obtained by an asymmetric hydrophosphonylation of quinazolinones (I).
ChemInform Abstract: Alternative Synthesis of Valganciclovir Hydrochloride.
Authors: Reddy Ganta Madhusudhan , Raju V. V. N. K. V. Prasada , Satyanarayana Kisara , Ravindra Vedantham , Venkateshwarlu G.
Published: May 2013

Title compound (I) is obtained via a novel strategy which circumnavigates several patent‐protected steps and does not involve an explicit deprotection procedure in the final step.
ChemInform Abstract: Nanoscale Stabilization of New Phases in the PbTe—Sb2Te3 System: PbmSb2nTem+3n Nanocrystals.
Authors: Soriano Ronald B. , Arachchige Indika U. , Malliakas Christos D. , Wu Jinsong , Kanatzidis Mercouri G.
Published: May 2013

Nanocrystals of the new compounds PbmSb2nTem+3n (m = 2, 3, 4, 6, 8, 10; n = 1, 2) are prepared from mixtures of lead acetate and antimony acetate in octadecene, oleic acid, and oleylamine, combined with Te in tri‐n‐octylphosphine (150—160 °C, 1 min).
ChemInform Abstract: The Iron‐Age of Superconductivity: Structural Correlations and Commonalities Among the Various Families Having —Fe—Pn— Slabs (Pn: P, As and Sb)
Authors: Ganguli Ashok K. , Prakash Jai , Thakur Gohil S.
Published: May 2013

Review: 212 refs.
ChemInform Abstract: Strongly Coupled Inorganic/Nanocarbon Hybrid Materials for Advanced Electrocatalysis
Authors: Liang Yongye , Li Yanguang , Wang Hailiang , Dai Hongjie
Published: May 2013

Review: 90 refs.
ChemInform Abstract: Structure and Properties of Water
Authors: Otto S. , Engberts J. B. F. N.
Published: May 2013

Review: 147 refs.
ChemInform Abstract: Thienannulation: Efficient Synthesis of π‐Extended Thienoacenes Applicable to Organic Semiconductors
Authors: Takimiya Kazuo , Nakano Masahiro , Kang Myeong Jin , Miyazaki Eigo , Osaka Itaru
Published: May 2013

Review: 101 refs.
ChemInform Abstract: Cascade Palladium‐ and Copper‐Catalyzed Aromatic Heterocycle Synthesis: The Emergence of General Precursors
Authors: Ball Catherine J. , Willis Michael C.
Published: May 2013

Review: 101 refs.
ChemInform Abstract: Enantioselective Synthesis of Helicenequinones and ‐bisquinones
Authors: Urbano Antonio , Carreno M. Carmen
Published: May 2013

Review: 37 refs.
ChemInform Abstract: Asymmetric Trienamine Catalysis: New Opportunities in Amine Catalysis
Authors: Kumar Indresh , Ramaraju Panduga , Mir Nisar A.
Published: May 2013

Review: 19 refs.
ChemInform Abstract: Asymmetric Organocatalytic Addition Reactions of Maleimides: A Promising Approach Towards the Synthesis of Chiral Succinimide Derivatives
Authors: Chauhan Pankaj , Kaur Jasneet , Chimni Swapandeep Singh
Published: May 2013

Review: 67 refs.
ChemInform Abstract: Acid‐Degradable Polymers for Drug Delivery: A Decade of Innovation
Authors: Binauld Sandra , Stenzel Martina H.
Published: May 2013

Review: 170 refs.
ChemInform Abstract: Methods of Synthesis and Properties of S‐Substituted 6‐Thiopurines (Review)
Authors: Aleksandrova E. V. , Kochergin P. M.
Published: May 2013

Review: 162 refs.
ChemInform Abstract: Synthesis of 6‐[18F]Fluorodopamine (6‐[18F]FDA)
Authors: Channing Michael A. , Musachio John L. , Kusmierz Jozef J.
Published: May 2013

Review: 14 refs.
ChemInform Abstract: Metal‐catalyzed Asymmetric Aldol Reactions
Authors: Dias Luiz C. , de Lucca Emilio C. Jr. , Ferreira Marco A. B. , Polo Ellen C.
Published: May 2013

Review: 104 refs.
ChemInform Abstract: Review Article on Vilsmeier—Haack Reaction
Authors: Rajput A. P. , Girase P. D.
Published: May 2013

Review: 192 refs.
ChemInform Abstract: Use of (+)‐Manool in the Synthesis of Natural Products. Part 1. Sesquiterpenes
Authors: Salazar Franklin J. , Villamizar Jose E.
Published: May 2013

Review: 62 refs.
ChemInform Abstract: Propargyl Claisen Rearrangement: Allene Synthesis and Beyond
Authors: Tejedor David , Mendez‐Abt Gabriela , Cotos Leandro , Garcia‐Tellado Fernando
Published: May 2013

Review: 64 refs.
ChemInform Abstract: Droplet Microfluidics — A Tool for Single‐Cell Analysis
Authors: Joensson Haakan N. , Andersson Svahn Helene
Published: May 2013

Review: ca. 200 refs.
ChemInform Abstract: Polyether Ionophores‐Promising Bioactive Molecules for Cancer Therapy
Authors: Huczynski Adam
Published: May 2013

Review: <50 refs.
ChemInform Abstract: Theoretical Studies and Industrial Applications of Oxidative Activation of Inert C—H Bond by Metalloporphyrin‐Based Biomimetic Catalysis
Authors: Liu Qiang , Guo Can Cheng
Published: May 2013

Review: 162 refs.
ChemInform Abstract: Crystal Structures of the Calcium Pump and Sarcolipin in the Mg2+‐Bound E1 State
Authors: Toyoshima Chikashi , Iwasawa Shiho , Ogawa Haruo , Hirata Ayami , Tsueda Junko , Inesi Giuseppe
Published: May 2013

Review: 42 refs.
ChemInform Abstract: Computational and Theoretical Studies
Authors: Papai I.
Published: May 2013

Review: 139 refs.
ChemInform Abstract: Arene—Arene Interactions and Application of Unimolecular Models for Their Understanding
Authors: Avasthi Kamlakar , Kumar Amar
Published: May 2013

Review: 145 refs.
ChemInform Abstract: Solid‐Phase Glycan Isolation for Glycomics Analysis
Authors: Yang Shuang , Zhang Hui
Published: May 2013

Review: 108 refs.
ChemInform Abstract: Getting the Most Out of HSQC and HMBC Spectra
Authors: Reynolds William F. , Burns Darcy C.
Published: May 2013

Review: 54 refs.
Liquid‐based cytology using cytorich red/tripath is diagnostically equivalent to conventional smears for bronchial washings and brushings and reduces the cost
Authors: Zendehrokh Nooreldin , Olejnicka Beata , Westman Agneta , Dejmek Annika
Published: May 2013

A split sample study was performed on 109 bronchial brushings and washings and evaluated from conventional slides (CS) and CytoRich Red/Tripath preparations (CRR/Tripath). Unassessable bronchial washings were significantly more frequent in CS (5 vs. 0), but as all brushings were assessable with both methods, no overall diagnostic advantage was found. CS and CRR/Tripath gave discordant diagnoses in one case with a final benign diagnosis and in six cases with final malignant diagnoses. In the benign case, atypia was assessed in CS. In the malignant cases, suspected malignancy was found in one CRR/Tripath and one CS, atypia vs. benign assessment was also balanced, with three atypias in CRR/Tripath and two in CS. The better preserved cells in CRR/Tripath facilitated correct diagnosis in some cases, but might also lead to false positive diagnoses. In small cell carcinomas diagnostic hints such as smearing and moulding were less pronounced in CRR/Tripath but this did not affect the diagnostic accuracy. Overall, the diagnostic performance with CRR/Tripath was at least as good as with conventional slides, although statistically no difference could be seen. The number of slides and screening time, and thereby cost was significantly reduced with CRR/Tripath, thus the liquid‐based method is preferred for bronchial washings and brushings. Diagn. Cytopathol. 2013;41:876–884.© 2013 Wiley Periodicals, Inc.
Giant cell tumor of bone presenting in the lumbar spine of a 35‐Year‐old Female
Authors: Witt Benjamin L. , Garcia Christopher A. , Cohen Michael B.
Published: May 2013

Fine‐needle aspiration (FNA) is commonly used in the evaluation of both primary and metastatic bone lesions. Giant cell tumor (GCT) of bone is one of the primary bone neoplasms that can be diagnosed with good success on FNA as its cytologic features are relatively reproducible. However, this entity classically involves the ends (or epiphyses) of the longs bones making anFNAdiagnosis of aGCTof bone in other anatomic locations is challenging and requires the consideration of a differential diagnosis. By invoking clinico‐radiographical correlation and maximizing our specimen, we were able to diagnose aGCTof bone involving the L1 vertebral body in a 35‐year‐old female. Diagn. Cytopathol. 2014;42:624–627. © 2013 Wiley Periodicals, Inc.
Functional defect of peripheral neutrophils in mice with induced deletion of CXCR2
Authors: Liu LiPing , Li MeiZhang , Spangler Lisa C. , Spear Charles , Veenstra Mike , Darnall Lindsey , Chang Cathleen , Cotleur Anne C. , Ransohoff Richard M.
Published: May 2013

Type 2 CXC chemokine receptor CXCR2 plays roles in development, tumorigenesis, and inflammation. CXCR2 also promotes demyelination and decreases remyelination by actions toward hematopoietic cells and nonhematopoietic cells. Germline CXCR2 deficient (Cxcr2‐/‐) mice reported in 1994 revealed the complexity of CXCR2 function and its differential expression in varied cell‐types. Here, we describe Cxcr2fl/fl mice for which the targeting construct was generated by recombineering based on homologous recombination in E. coli. Without recombination Cxcr2fl/fl mice have CXCR2 expression on neutrophils in peripheral blood, bone marrow and spleen. Cxcr2fl/fl mice were crossed to Mx‐Cre mice in which Cre recombinase is induced by Type I interferons, elicited by injection with polyinosinic‐polycytidylic acid (poly(I:C)). CXCR2‐deficient neutrophils were observed in poly(I:C) treated Cxcr2fl/fl::Mx‐Cre+ (Cxcr2‐CKO) mice, but not in poly(I:C) treated Cxcr2f//+::Mx‐Cre+ mice. CXCR2 deletion was mainly observed peripherally but not in the CNS. Cxcr2‐CKO mice showed impaired neutrophil migration in sterile peritonitis. Cxcr2‐CKO mice reported here will provide a genetic reagent to dissect roles of CXCR2 in the neutrophil granulocyte lineage. Furthermore Cxcr2fl/fl mice will provide useful genetic models to evaluate CXCR2 function in varied cell populations. genesis 51:587–595. © 2013 Wiley Periodicals, Inc.
UDP‐glucose enhances outward K+ currents necessary for cell differentiation and stimulates cell migration by activating the GPR17 receptor in oligodendrocyte precursors
Authors: Coppi Elisabetta , Maraula Giovanna , Fumagalli Marta , Failli Paola , Cellai Lucrezia , Bonfanti Elisabetta , Mazzoni Luca , Coppini Raffaele , Abbracchio Maria P. , Pedata Felicita , Pugliese Anna Maria
Published: May 2013

In the developing and mature central nervous system, NG2 expressing cells comprise a population of cycling oligodendrocyte progenitor cells (OPCs) that differentiate into mature, myelinating oligodendrocytes (OLGs). OPCs are also characterized by high motility and respond to injury by migrating into the lesioned area to support remyelination. K+ currents in OPCs are developmentally regulated during differentiation. However, the mechanisms regulating these currents at different stages of oligodendrocyte lineage are poorly understood. Here we show that, in cultured primary OPCs, the purinergic G‐protein coupled receptor GPR17, that has recently emerged as a key player in oligodendrogliogenesis, crucially regulates K+ currents. Specifically, receptor stimulation by its agonist UDP‐glucose enhances delayed rectifier K+ currents without affecting transient K+ conductances. This effect was observed in a subpopulation of OPCs and immature pre‐OLGs whereas it was absent in mature OLGs, in line with GPR17 expression, that peaks at intermediate phases of oligodendrocyte differentiation and is thereafter downregulated to allow terminal maturation. The effect of UDP‐glucose on K+ currents is concentration‐dependent, blocked by the GPR17 antagonists MRS2179 and cangrelor, and sensitive to the K+ channel blocker tetraethyl‐ammonium, which also inhibits oligodendrocyte maturation. We propose that stimulation of K+ currents is responsible for GPR17‐induced oligodendrocyte differentiation. Moreover, we demonstrate, for the first time, that GPR17 activation stimulates OPC migration, suggesting an important role for this receptor after brain injury. Our data indicate that modulation of GPR17 may represent a strategy to potentiate the post‐traumatic response of OPCs under demyelinating conditions, such as multiple sclerosis, stroke, and brain trauma.
On the parameterization of surface momentum transport via drag coefficient in low‐wind conditions
Authors: Zhu Ping , Furst Jonathan
Published: May 2013

The subgrid‐scale surface momentum transport, which plays an important role in determining the exchange between the atmosphere and the underlying surface, is often parameterized in terms of the surface mean wind speed via drag coefficient (CD), a parameter that needs to be determined externally often through the Monin‐Obukhov Similarity (MOS) Theory. However, some characteristics of CD derived from observations for overland conditions, particularly the substantial increase of CD with a decrease in wind speed in low‐wind conditions, cannot be explained by MOS. This issue is investigated using data collected by a portable meteorological tower. By analyzing the turbulent kinetic energy budget, a novel parameterization framework for momentum fluxes is proposed. The new parameterization not only appropriately describes the observed variation of CD but also can be simplified to MOS with certain assumptions. Moreover, the effect of stability, which traditionally has to be determined empirically, can now be determined internally within the new framework.
Diabetes mellitus and corticotherapy as risk factors for alendronate‐related osteonecrosis of the jaws: A study in Wistar rats
Authors: Berti–Couto Soraya A. , Vasconcelos Ana Carolina U. , Iglesias Júlia E. , Figueiredo Maria Antonia Z. , Salum Fernanda G. , Cherubini Karen
Published: May 2013

Background

The purpose of this study was to investigate the influence of diabetes and corticotherapy on the development of osteonecrosis of the jaws associated with sodium alendronate.

Methods

Rats were allocated into 4 groups of 11 animals each, representing different treatments: (1) alendronate; (2) alendronate and corticotherapy; (3) alendronate and diabetes; and (4) control. Tooth extractions were performed in all animals, and histological analysis was performed by hematoxylin and eosin staining and immunohistochemistry using anti‐bone morphogenetic protein (BMP)‐4 and anti‐matrix metalloproteinase (MMP)‐13 antibodies.

Results

On hematoxylin and eosin analysis, proportions of inflammatory infiltrate, microbial colonies, and osteonecrosis were significantly greater in the diabetes group. BMP‐4 expression in connective tissue was higher in the corticosteroid group than the alendronate group. There were no significant differences between the other groups. MMP‐13 expression did not differ between the groups analyzed.

Conclusion

Diabetes but not corticotherapy is associated with jaw osteonecrosis in rats undergoing alendronate therapy and subjected to tooth extractions. © 2013 Wiley Periodicals, Inc. Head Neck 36: 84–93, 2014
Spatial and temporal variations of albedo on nine glaciers in western China from 2000 to 2011
Authors: Wang Jie , Ye Baisheng , Cui Yuhuan , He Xiaobo , Yang Guojing
Published: May 2013

This research demonstrates the spatiotemporal variations of albedo on nine glaciers in western China during 2000–2011, by the albedo derived from two types of datasets: Landsat TM/ETM + images and MOD10A1 product. Then, the influence factors of glacier albedo and its relationship with glacier mass balance are also analyzed by the correlation approach, which is frequently used in geostatistics. The paper finds that there are different spatiotemporal variations over the glaciers in western China: (1) For a single glacier, the albedo varies gently with altitude on its tongue and increases fast in the middle part, while in the accumulation zones, the albedo value appears in the form of fluctuation. This could provide a quantitative method to retrieve the snowline by determining the threshold albedo value of snowpack and bare ice. (2) For the glaciers in western China, the albedo decreases with distance to the center of Tibetan Plateau (TP). This may relate to the elevation of glacier, for the speed of glacier retreat highly depends on air temperature. (3) In the summer period, albedo on most glaciers declines over the last 12 years, and it decreases much faster in southeastern TP than other regions, for which air temperature overwhelms the black carbon concentration. In addition, the trend of glacier albedo in summer is greatly correlated with that of measured glacier mass balance, which implies that the long‐term albedo datasets by remote sensing technology could be used to monitor and predict the change of glacier mass balance in the future. Copyright © 2013 John Wiley & Sons, Ltd.