bluuebunny/crossref_metadata_2025 huggingface dataset:
In Vitro Xanthine Oxidase Inhibitory Activity of Morinda citrifolia L. (Noni) Leaf and Identification of Its Xanthine Oxidase Inhibitors
Authors: Thipwong Jaturon , Kongton Kittima , Nupan Benjamas
Published: December 2022

Hyperuricemia causes an excessive level of uric acid in the body, which leads to the formation of gouty arthritis and high uric acid-related diseases. To cure this condition, xanthine oxidase (XO), a key enzyme in uric acid production, was targeted. A routinely used XO inhibitor drug, allopurinol, has side effects. Therefore, an alternative XO inhibitor with a high activity and fewer side effects is strongly desired. In this research, we evaluated the XO inhibitory activity of Morinda citrifolia L. (noni) leaves extracted using 2 solvents, 95 % ethanol and water. The total phenolic and flavonoid content was analyzed. Moreover, the phenolic profile was investigated using liquid column chromatography-mass spectrometry (LC-MS). The results showed that at a concentration of 100 µg mL−1, the ethanolic (McE) and water (McW) extracts could exhibit XO inhibitory activity above 90 %, and the IC50 values predicted using dose-response logarithmic function curves were 2.24 ± 0.2 and 7.2 ± 0.1 µg mL−1, respectively, while the IC50 of allopurinol was 1.02 ± 0.1 µg mL−1. The total phenolic and flavonoid content in McE was higher than that in McW. LC-MS analysis revealed that all extracts contained several phenolic compounds. Interestingly, known potent XO inhibitors were found in both extracts. Kaempferol, esculetin, saponarin, physcion and g-aminobutyric acid were found in McE, while McW contained esculetin, saponarin and rutin. Taken together, M. citrifolia L. leaves could be used as an effective alternative XO inhibitor for curing hyperuricemia and high uric acid-related diseases caused by XO activity.
HIGHLIGHTS

The XO inhibitory activity of Morinda citrifolia (noni) leaves was reported for the first time
An ethanolic leaf extract (McE) contained higher total phenolic and total flavonoid content than a water extract (McW)
Both noni extracts contained the known potent XO inhibitor by kaempferol, esculetin, saponarin, physcion and g-aminobutyric acid were also found in McE, while, McW contained esculetin, rutin, and saponarin

GRAPHICAL ABSTRACT
Duku (Lansium domesticum) Leaves Extract Induces Cell Cycle Arrest and Apoptosis of HepG2 Cells via PI3K/Akt Pathways
Authors: Lubis Muhammad Fauzan , Hasibuan Poppy Anjelisa Zaitun , Syahputra Hafid , Keliat Jane Melita , Kaban Vera Estefania , Astyka Ririn
Published: December 2022

Liver cancer is a type of malignant cancer that causes many deaths in the world. Efforts to find natural ingredients that can be used to treat liver cancer are very important. This study investigated the anticancer activity of ethanol extract of Duku (Lansium domesticum) leaves (LDE) through the cytotoxic activity, cell cycle inhibition mechanism and apoptosis influence through the PI3K/Akt pathways. Secondary metabolites of LDE were determined by common qualitative method. Cell cycle arrest was carried out by flow cytometer at inhibitory concentration 50 (IC50), while the apoptosis test was obtained using double staining method. The IC50 value was used to identifying the expression of PI3K/Akt genes. The analyzed results were proven LDE can induce HepG2 cell death which IC50 value of 19.93 ± 0.93 μg/mL (ethanol extract), 267.06 ± 3.24 μg/mL (ethyl acetate extract), and 216.47 ± 2.87 μg/mL (n-hexane extract). Cell cycle arrest activity in HepG2 cells which IC50 value of ethanol extract of LDE occurs in S phase. Observation of apoptosis occurrence was obtained getting apoptosis in cell line.  PI3K/Akt genes expression of ethanol extract of LDE was obtained using RT-PCR method. The bands density of PI3K/Akt at IC50 value treatment of 0.55 ± 0.02; 0.25 ± 0.01. The LDE was determined to contain secondary metabolites which can inhibit the growth of HepG2 cells through PI3K/Akt pathways.

HIGHLIGHTS

The ethanolic extract of Lansium domesticum leaves have the best cytotoxic activity against HepG2 cells line compared to ethyl acetate extract and n-hexane extract

The ethanolic extract of Lansium domesticum leaves have anticancer activity against HepG2 cells line through cell cycle arrest and apoptosis induce

The ethanolic extract of Lansium domesticum leaves can inhibit the expressions of PI3K/Akt/mTOR genes using RT-PCR

GRAPHICAL ABSTRACT
AMİSOS NEKROPOLÜNDEN ÇATI KİREMİTLERİYLE YAPILMIŞ MEZARLAR ÜZERİNE BAZI DEĞERLENDİRMELER
Authors: ŞİRİN Orhan Alper
Published: December 2022

Miletos kolonizasyonunun etkisiyle, MÖ 6. yüzyılın ortalarında Çakalca-Karadoğan Höyüğü olarak adlandırılan yerleşim alanında varlık göstermeye başlayan Amisos kenti, zamanla siyasi ve ekonomik olarak gelişip liman hacminin genişlemesiyle, MÖ 4. yüzyılın sonlarında bugünkü Cedit Mahallesi’ndeki Toraman Tepe ve çevresine konumlandırılmıştır. Konumlanan bu alan, kentin akropolünü ve nekropolün bir kısmını içine almaktadır. Kent yerleşiminin doğu eteklerinde çeşitli mezar yapıları açığa çıkmıştır. Bu mezarlardan çatı kiremidi ile yapılmış olan bazı mezar kalıntıları bu çalışmada ele alınmıştır. Kentin yayılım alanında açığa çıkan kiremit mezarlara değinerek mezar yapılarında kullanılan çatı kiremitleri ile mezar buluntularının analoji odaklı karşılaştırmaları yapılmıştır. Ayrıca çatı kiremitlerinin kullanımına ilişkin arkeolojik verilere genel hatlarıyla yer verilmiş, kiremitlerin tipolojisi ve gömü geleneğinde bu kiremitlerin kullanımı üzerinde de çeşitli çıkarımlarda bulunulmaya çalışılmıştır. Böylelikle Amisos’un çatı kiremitleri ile yapılmış mezar yapıları ele alınarak bölge arkeolojisine katkı sağlanması amaçlanmıştır.
Hemgenix as First Gene Therapy for Treatment of Haemophilia B
Authors: Mr. Sachin Navale  , Miss. Kaveri Bhosale  , Mr. Mahesh Mohite  , Mrs. Swapnali Navale
Published: December 2022

We know about haemophilia B is an inheritable bleeding complaint performing from missing or inadequate situations of blood clotting Factor IX, a protein demanded to produce blood clots to stop bleeding. Haemophilia B is a rare, lifelong bleeding complaint caused by a single gene disfigurement, performing an inadequate product of factor IX, a protein primarily produced by the liver that helps blood clots form. Treatments for moderate to severe haemophilia B include precautionary infusions of factor IX relief remedy to temporarily replace or condense low situations of blood- clotting factor and, while these curatives are effective, those with haemophilia B must cleave to strict, lifelong infusion schedules. But lately US FDA authorize hemegenix for haemophilia. the first and only one- time gene remedy for applicable grown-ups with haemophilia. Hemgenix is approved for the treatment of grown-ups with haemophilia B who presently use factor IX Prophylaxis remedy.
Dostarlimab : A Step Against Cancer
Authors: Alisha H. Mujawar  , Sachin S. Navale  , Nilofer S. Sayyad  , Shrutika R. Kadam  , Rushikesh M. Sankpal  , Punam D. Mali
Published: December 2022

Immunotherapy have become the backbone in the treatment of cancer recently. Immune checkpoint inhibitors checkpoint therapy, monoclonal antibody therapy and chimeric antigen T-cell therapy have shown the peak level exceptional properties that activate the immune system to response to cancer cells, inhibiting their progression. Immune checkpoint inhibitors have demonstrated significant clinical activity across various types of tumor. Nowadays dostarlimab a new drug have been showing a miracle in the treatment of rectal cancer. In Year 2022 June, the clinical trial NCT04165772 reported a 100% remission rate for rectal cancer. This clinical trial have proved that they can match a tumor and the genetics of what is driving it, with therapy. Dostarlimabis approved on August 17,2021 by the U.S Food and Drug Administration (FDA) which treat mismatch repair deficient (dMMR) advanced-stage breast cancer Dostarlimab is a humanized monoclonal antibody that works by binding with high affinity to PD-1 resulting in inhibition of binding to PD-L1 and PD-L2. Research is done on the study of effect of dostarlimab on various patients.
Power Theft Smart Detection System
Authors: Shubham Sangle  , Harshal Wadekar  , Harshal Wadekar  , Prof. Mundhe B. B  , Prof. Dr. Khatal S. S
Published: December 2022

Bypassing or hooking are the two main strategies used to steal power. The home current distribution is therefore done indirectly from the electric pole to an intermediate distributor box and then to the individual residences in order to identify it, a method (current measurement and comparison) is recommended. Periodically, the current in the distributor box is measured, and using a GSM/GPRS module, each house's current is sent to the server database. Similar to this, each home's electric metre is built to measure current value and regularly send it to the server database using GSM/GPRS module. A user-friendly mobile application is used to save the users' information in the database at the time of electric metre installation. This information includes the address, latitude, longitude, and a photo of the user's home or region using mobile GPS. If we find even a little variation between the current numbers after successfully comparing those from the electric metre and distributor box in the server, then the theft has been discovered. Finally, the user's information, including the area's address and photo, is exchanged with the approved mobile application. The region of the theft is also displayed on Google maps using the latitude and longitude. Therefore, the necessary actions are done..
An Immutable Data Storage using Algorand Blockchain (ABC) Consensus Mechanism in the Supply CHAIN
Authors: M. C. Jayaprasanna  , Dr. S. Sujatha
Published: December 2022

In recent years, many frameworks and applications have been proposed to ensure tamper resistant data in supply chain using Block chain technologies. Block chain technology as a base design ensures that the content of the information is ‘tamper-resistant’. So far, no other study was presented with a low impact on the environment and minimum cost for each transaction sent by the supply chain. In order to protect the access of malicious user, we tend to propose an immutable data storage environment that is based on Algorand Blockchain. It uses the Pure Proof-of-Stake mechanism of consensus that needs less computational power, and is highly scalable and environmentally sustainable. It will make the data immutable and available in real-time for final consumers. Hence it can tolerate malicious users and achieving consensus without a central authority.
Freedom is a Point of Departure, Not a Horizon
Authors: Smith Jeremy
Published: December 2022

The following is a review of the recently published translation of Theory of the Solitary Sailor by Gilles Grelet (trans. Amy Ireland and Robin Mackaye, Falmouth: Urbanomic, 2022). It highlights the significance of the work, its major stakes, and asks questions regarding the future of Grelet's methodical anti-philosophical invention.
Author(s): Jeremy R. Smith
Title (English): Freedom is a Point of Departure, Not a Horizon
Journal Reference: Identities: Journal for Politics, Gender and Culture, Vol. 19, No. 1-2 (2022).
Publisher: Institute of Social Sciences and Humanities - Skopje
Page Range: 176-180
Page Count: 4
Citation (English): Jeremy R. Smith, "Freedom is a Point of Departure, Not a Horizon,” Identities: Journal for Politics, Gender and Culture, Vol. 19, No. 1-2 (2022): 176-80.
Author Biography
Jeremy R. Smith, Western University
Jeremy R. Smith is a PhD Candidate at the Centre for the Study of Theory and Criticism at Western University. He is a co-founder and co-editor of Oraxiom: A Journal of Non-Philosophy.
After Liberalism
Authors: Kolozova Katerina
Published: December 2022

Author(s): Katerina Kolozova
Title (English): After Liberalism
Journal Reference: Identities: Journal for Politics, Gender and Culture, Vol. 19, No. 1-2 (2022).
Publisher: Institute of Social Sciences and Humanities - Skopje
Page Range: 40-47
Page Count: 7
Citation (English): Katerina Kolozova, "After Liberalism,” Identities: Journal for Politics, Gender and Culture, Vol. 19, No. 1-2 (2022): 40-47.
Author Biography
Katerina Kolozova, Institute of Social Sciences and Humanities, Skopje
Dr. Katerina Kolozova is Executive Director, senior researcher and full professor at the Institute of Social Sciences and Humanities, Skopje, and a professor of political philosophy at FMK-Belgrade. She has published many influential articles in a number of international journals, as well as several books. These include: Capitalism’s Holocaust of Animals: A Non-Marxist Critique of Capital, Philosophy and Patriarchy (Bloomsbury Academic), as well as Cut of the Real: Subjectivity in Poststructuralist Philosophy (Columbia University Press).
The Withering away of which State?
Authors: De Jong Zachary
Published: December 2022

Communism and the state share, historically, an intrinsic link, so much so that, at least in North America, state control, totalitarianism, and communism have become practically synonymous with each other in general parlance. Marx, and countless Marxists after him, however, advocated for the disappearance of the state, taking aim at the state’s role, and complicity in, forwarding and perpetuating class inequalities, and the entire structure of capital itself. In this same sense, the state can be seen as a form of meta-structure, reinforcing through law, force, and ideology, the internal logic of capitalism itself. Thus, while also exploring what the state as such is, this talk will ask: what then does the disappearance of the state mean today, how do these forms of hegemonic control function across a wide range of variegated contexts, and through what modes can we resist them?
Author(s): Zachary De Jong
Title (English): The Withering away of which State?
Journal Reference: Identities: Journal for Politics, Gender and Culture, Vol. 19, No. 1-2 (2022).
Publisher: Institute of Social Sciences and Humanities - Skopje
Page Range: 48-56
Page Count: 8
Citation (English): Zachary De Jong, "The Withering away of which State?,” Identities: Journal for Politics, Gender and Culture, Vol. 19, No. 1-2 (2022): 48-56.
Author Biography
Zachary De Jong, Institute of Social Sciences and Humanities, Skopje
Zachary De Jong is a researcher and graduate student at the Institute of Social Sciences and Humanities, Skopje. His research is focused on examining Marxist and materialist conceptions of what a post-capitalist or communist society could look like going forward. He has published an article on this topic entitled: “Reimagining the Oikos” (Identities: Journal for Politics, Gender and Culture).
Преиспитување на Вториот бран на феминизмот во светло на неодамнешните контроверзи
Authors: Пауер Нина
Published: December 2022

Овој труд ги разгледува елементите на Вториот бран на феминизмот – во неговите психоаналитички, радикални, материјалистички, марксистички и деконструктивистички аспекти – за подобро разбирање на тоа како би било најдобро да се дефинира половата различност денес. Вознемирувачкото прашање на сексуацијата (произведеното од пол) за тоа што значи да се биде жена особено, денес генерираа големи тензии на теориско, правно и филозофско ниво. Оваа статија е обид да се наврати на аспектите на вториот бран – недовршениот проект каде многу трајни феминистички проблеми беа за првпат темелно и метафизички артикулирани – подобро да се одбрани важноста на половата разлика. За таа цел, ќе бидат дискутирани трансценденталните и паралаксичните димензии на половиот живот, заедно со одбраната на централноста на мајката за нашето мислење околу релевантноста и нужноста на зачувувањето на важноста на сексуалната различност, не само во мисловниот, туку и во политичкиот и правниот живот.
 
Author(s): Нина Пауер 
Title (Macedonian): Преиспитување на Вториот бран на феминизмот во светлона неодамнешните контроверзи
Journal Reference: Identities: Journal for Politics, Gender and Culture, Vol. 19, No. 1-2 (2022).
Publisher: Institute of Social Sciences and Humanities - Skopje
Page Range: 110-121
Page Count: 11
Citation (Macedonian): Нина Пауер, "Преиспитување на Вториот бран на феминизмот во светлона неодамнешните контроверзи,” Identities: Journal for Politics, Gender and Culture, Vol. 19, No. 1-2 (2022): 110-121.
Author Biography
Нина Пауер, Независна истражувачка
Нина Пауер е филозофка и писателка, авторка на многу статии поврзани со политиката, феминизмот и културата. Таа е авторка на Еднодимензионална жена (2009) и на претстојната Што сакаат мажите? (2021). Во моментов предава на Мери Вард (Mary Ward), додека пак претходно предаваше на Универзитетот на Роехамптон (University of Roehampton) и многу други институти.
Етиката на смртта
Authors: Неил Томас
Published: December 2022

Author(s): Томас Неил 

Title (Macedonian): Етиката на смртта

Journal Reference: Identities: Journal for Politics, Gender and Culture, Vol. 19, No. 1-2 (2022).

Publisher: Institute of Social Sciences and Humanities - Skopje

Page Range: 122-135

Page Count: 13

Citation (Macedonian): Томас Неил , "Етиката на смртта,” Identities: Journal for Politics, Gender and Culture, Vol. 19, No. 1-2 (2022): 122-135.
The Use of Cooperative Method Type Student Teams Achievement Division as an Effort to Increase Student Learning Outcomes in Fiqh Subjects at the Integrated Madani Islamic Elementary School in Aceh Tenggara
Authors: Harli Harli
Published: December 2022

This study aims to determine student learning outcomes in the subject of Fiqh before and after using the Student Teams Achievement Division learning model and to determine the effectiveness of students in class during learning. This study uses the type of Classroom Action Research (CAR) with II cycles and each cycle consists of planning, implementing, observing, and reflecting through the application of the Student Teams Achievement Division learning model in the Fiqh subject on Freedom of Organization. Based on the research results, it can be concluded that student learning outcomes before the action only get an average score of 64.41 or 21% success rate. After the application of the Student Teams Achievement Division learning model in cycle I, students Fiqh learning outcomes had an average score of 70.52 or 52.6% student success rate. In cycle II, an average score of 83.16 or 83.21% was obtained for the success rate of the students. This Classroom Action Research can be said to increase by using the Student Teams Achievement Division learning model.
Penanaman Nilai Karakter Peserta Didik Melalui Program Pengembangan Diri
Authors: Parinduri Rifdah Hasan , Aj Pahruzi Riskang , Sutrisno Sutrisno
Published: December 2022

The purpose of this study was to determine the effect of self-development programs for students implemented at Madrasah Tsanawiyah Muallimin Univa Medan, as well as leadership policies in instilling character values. In addition, it also aims to find out what supports and hinders the cultivation of character values ??through self-development programs at Madrasah Tsanawiyah Muallimin Univa Medan. This research is included in the category of qualitative research using a phenomenological perspective. The findings of this study show how Madrasah Tsanawiyah Muallimin Univa Medan integrates the development of character values ??into learning by focusing on three different areas: teaching, modeling, and assessment. Madrasah Tsanawiyah Muallimin Univa Medan implements the policy of the madrasah head to teach character values ??through working meetings with the teacher council in the context of instilling character values ??in students. In addition, this study examines the facilitating and inhibiting elements that influence how students at Madrasah Tsanawiyah Muallimin Univa Medan build character.
Implementasi Model Pembelajaran Make A Match Dengan Pendekatan Contextual Teaching And Learning Untuk Meningkatkan Kemampuan Menulis Teks Berbentuk Procedure Pada Siswa Kelas XII MIPA 1 Man 1 Bungo
Authors: Karim Karim
Published: December 2022

This Classroom Action Research Aims to improve Students' Ability to write Texts in The Form Of Procedure. Based on the results of tests carried out by the author before conducting classroom action research and the results of observations during the teaching and learning process at MAN 1 Bungo, especially class XII IPA 1, most students have not been able to write text in the form of procedures. Procedure text learning is contained in the curriculum standard at the unit level of education (KTSP) in class XII semester 1. By using the Make a Match learning model, it is expected that students' ability to write procedure texts will increase. The results of this classroom action research showed that students' ability to write procedure texts could increase. This lies in the actions that researchers perform in each cycle 1, namely cycle 1 and cycle 2. This PTK was carried out in class XII IPA 1 MAN 1 Bungo with 2 cycles. In each cycle planning, implementing actions, observing, and reflecting on data were carried out. The collected data is processed quantitatively. Thus it can be emphasized that the Make a Match learning model can be used as an alternative to improve students' ability to write procedure texts in class XII IPA 1 MAN 1 Bungo. The results of the actions of each cycle obtained an overview of the results of cycle 1. The success rate of students reached an average of 67.4 with good category abilities. In cycle 2 the success of students reached an average of 73.85 with good category ability.
Sentiment Analysis of Customer Feedback Reviews Towards Hotel’s Products and Services in Labuan Bajo
Authors: Christanto Henoch Juli , Singgalen Yerik Afrianto
Published: December 2022

The feedback review column on the TripAdvisor website can process the sentiment analysis by classifying the positive and negative impressions of the consumer using machine learning, namely text mining. This study analyzes consumer sentiment for hotel products and services in Labuan Bajo based on feedback review data on the TripAdvisor website. Meanwhile, the algorithm used is Nave Bayes Classifier (NBC), Support Vector Machine (SVM), also SMOTE Upsampling for the k-Nearest Neighbor (k-NN) algorithm. The classification result shows 702 negative feedback reviews and 2531 positive feedback reviews. The evaluation of algorithm performance shows the accuracy of SVM is 78,30% and NBC is 78,29% compared with k-NN with 85,24% accuracy, using SMOTE Upsampling with a class precision description of 100% prediction negative (1784 true Neg & 0 true Pos) and 77,21% prediction positive (747 true Neg & 2531 true Pos). The class recall description also shows 70,49% true Negative (1784 pred Neg & 747 pred Pos) and 100% true Positive (0 pred Neg & 2531 pred Pos). These findings indicate that the k-NN algorithm shows the best result instead of the SVM and NBC algorithm, according to the sentiment analysis result of customer feedback reviews on hotel products and services in Labuan Bajo through TripAdvisor website.
Ways to improve the regulation of the grounds and conditions for exemption from criminal liability
Authors: Овсянников Игорь Владимирович
Published: December 2022

В статье предпринята попытка высветить неоднозначность, неясность и несогласованность некоторых норм правового института освобождения от уголовной ответственности. Предметом исследования являются статистические данные о состоянии преступности, нормы уголовного и уголовно-процессуального законов, правовая позиция Пленума Верховного Суда Российской Федерации, научная литература по теме работы. Цель исследования - сформулировать предложения по совершенствованию терминологии уголовного закона, чтобы от ответственности освобождалось не лицо, совершившее преступление, а участник уголовного судопроизводства - подозреваемый, обвиняемый, подсудимый, а также предложить пути конкретизации, уточнения и дополнения указанных в уголовном законе необходимых и в совокупности достаточных оснований и условий, которые могут или должны влечь освобождение от уголовной ответственности. В результате проведенной работы критически проанализировано использование в уголовном законе понятия «совершение преступления впервые»; возможность решения вопроса об освобождении от уголовной ответственности лица, ранее освобождавшегося от нее, по усмотрению суда. Практическое значение итогов работы в том, что они могут способствовать законности принимаемых судами процессуальных решений, единообразию судебной практики, соблюдению конституционного положения о равенстве всех перед законом и судом, позитивному постпреступному поведению подозреваемых и обвиняемых.

In the article the author attempts to highlight the ambiguity, obscurity and inconsistency of some norms of the legal institution of exemption from criminal liability. The subject of the study is statistical data on the state of crime, the norms of criminal and criminal procedure laws, the legal position of the Plenum of the Supreme Court of the Russian Federation, and the scientific literature on the topic of the work. The purpose of the study is to formulate proposals for improving the terminology of the criminal law so that it is not the person who committed the crime that is exempted from liability, but the participant in criminal proceedings - the suspect, the accused, the defendant, as well as to suggest ways of concretizing, clarifying and supplementing the necessary and, in the aggregate, sufficient specified in the criminal law grounds and conditions that may or should entail exemption from criminal liability. As a result of the work carried out, the use of the concept of «committing a crime for the first time» in the criminal law was critically analyzed; the possibility of resolving the issue of exemption from criminal liability of a person previously exempted from it, at the discretion of the court. The practical significance of the results of the work is that they can contribute to the legality of procedural decisions made by the courts, the uniformity of judicial practice, the observance of the constitutional provision on the equality of all before the law and the court, and the positive post-criminal behavior of suspects and defendants.
All-Russian scientific and practical conference «Organizational and legal aspects of the activities of law enforcement agencies of the Russian Federation and foreign countries: theory and practice»
Authors: Павлова Людмила Владимировна , Дугенец Александр Сергеевич
Published: December 2022

21.10.2022 в Научно-исследовательском институте ФСИН России состоялась Всероссийская научно-практическая конференция «Организационно-правовые аспекты деятельности правоохранительных органов Российской Федерации и зарубежных стран: теория и практика». В ходе состоявшегося обмена мнениями выступающие отметили и высказали различные точки зрения на проблемы организационно-правового характера и перспективы развития деятельности правоохранительных органов Российской Федерации и зарубежных стран.

On October 21, 2022, the All-Russian scientific and practical conference «Organizational and legal aspects of the activities of law enforcement agencies of the Russian Federation and foreign countries: theory and practice» was held at the Research Institute of the FPS of Russia. During the exchange of views, the speakers noted and expressed various points of view on the problems of an organizational and legal nature and the prospects for the development of the activities of law enforcement agencies of the Russian Federation and foreign countries.
Features of the allocation of guarantees as an independent element of the administrative and legal status of employees of security units (of regime and supervision) of institutions and bodies of the penal system of the Russian Federation
Authors: Григорьева Ольга Олеговна
Published: December 2022

Приближающийся 30-летний юбилей подразделений безопасности (режима и надзора) учреждений и органов уголовно-исполнительной системы Российской Федерации вызвал исследовательский интерес к должностному статусу сотрудников УИС в связи с замещением должностей указанных подразделений, а именно - к гарантиям. Наиболее часто ученые рассуждают о гарантиях законности и социальных гарантиях, которые даже на законодательном уровне периодически приравниваются к правам, хотя в теории административного права гарантии и права являются самостоятельными элементами правового статуса. Административно-правовые гарантии рассматриваются в качестве инструмента управления персоналом. Обосновано предложение об изменении расчета отпуска за стаж службы в УИС и установлении надбавки «за неукомплектованность» в виде мер, предупреждающих спрогнозированные автором риски: новую волну оттока кадров; риск повышения уровня коррупции; ухудшение морально-психологической обстановки в коллективе. Все примеры связаны со спецификой службы в отделах безопасности и отделах режима и надзора, но общие тенденции могут рассматриваться по аналогии как для Федеральной службы исполнения наказаний в целом, так и для других правоохранительных органов.

The approaching 30th anniversary of the security units (of regime and supervision) of institutions and bodies of the penitentiary system of the Russian Federation has aroused research interest in the official status of penitentiary officers in connection with filling the positions of these units, namely, guarantees. Most often, scientists talk about guarantees of legality and social guarantees, which even at the legislative level are periodically equated with rights, although in the theory of administrative law, guarantees and rights are independent elements of legal status. Administrative and legal guarantees are considered as a tool for personnel management. The proposal is substantiated to change the calculation of a leave for length of service in the penal system and to establish an allowance «for understaffing» in the form of measures that prevent the risks predicted by the author: a new wave of outflow of personnel; increase in the level of corruption; an increase in cases of suicide among employees due to debt obligations; deterioration of the moral and psychological situation in the team as one of the consequences of extending the age limit for service. All examples are related to the specifics of the service in security departments and regime and supervision departments, but general trends can be considered by analogy both for the Federal Penitentiary Service in general and for other law enforcement agencies.
On the planning of educational work with juvenile convicts in the 1960s
Authors: Лелик Наталия Борисовна , Ефименко Александр Александрович
Published: December 2022

В статье рассматриваются актуальность и проблемы планирования воспитательной работы с несовершеннолетними осужденными в трудовых колониях 1960-х годов. Акцентируется внимание на решении главных задач - воспитании и исправлении нравственно запущенных несовершеннолетних правонарушителей. Особое внимание уделено внеклассной и внешкольной работе учителей и мастеров с воспитанниками, производственной деятельности подростков, их занятиям в технических и художественных кружках под руководством наставников. Представлены основные разделы плана воспитательной работы, учитывающие укрепление дисциплины среди несовершеннолетних, предотвращение происшествий и аморальных проявлений. Дан анализ формам политико-воспитательной работы (политические занятия, политинформации, беседы, доклады, лекции, читательские конференции, диспуты, устные журналы, организованное чтение газет и журналов, прослушивание радиопередач, выпуск стенгазет, просмотр кинофильмов и телепередач, оформление наглядной агитации). Отражена специфика организации учебно-воспитательного процесса в воспитательных колониях с учетом уголовно-исполнительного законодательства Российской Федерации. В заключение приводятся результаты анализа характерных недостатков при планировании воспитательной работы в трудовых колониях для несовершеннолетних в 1960-х годах.

In the article the author discusses the relevance and problems of planning educational work with juvenile convicts in labor colonies in the 1960s. Attention is focused on solving the main tasks - the education and correction of morally neglected juvenile offenders. Particular attention is paid to extra-curricular and out-of-school work of teachers and craftsmen with pupils, the production activities of adolescents, their studies in technical and artistic circles under the guidance of mentors. The main sections of the plan of educational work are presented, taking into account the strengthening of discipline among minors, the prevention of accidents and immoral manifestations. An analysis is given of the forms of political and educational work (political studies, political information, conversations, reports, lectures, reader's conferences, debates, oral journals, organized reading of newspapers and magazines, listening to radio broadcasts, publishing wall newspapers, watching films and television programs, designing visual agitation). The specificity of the organization of the educational process in educational colonies is reflected, taking into account the criminal executive legislation of the Russian Federation. In conclusion, the results of the analysis of characteristic shortcomings in the planning of educational work in labor colonies for minors in the 1960s are presented.
International scientific and practical conference «The penitentiary system of Russia in the modern conditions of the development of society: from the paradigm of punishment to correction and resocialization»
Authors: Черешнева Людмила Алексеевна
Published: December 2022

Вологодским институтом права и экономики Федеральной службы исполнения наказаний была организована и проведена научно-практическая конференция «Пенитенциарная система России в современных условиях развития общества: от парадигмы наказания к исправлению и ресоциализации». Главной целью мероприятия стал комплексный анализ проблем современной пенитенциарной системы России. В работе конференции приняли участие более 200 высококвалифицированных специалистов. Среди них - представители научных организаций уголовно-исполнительной системы, профессорско-преподавательского состава ведомственных вузов, центрального аппарата ФСИН России, сотрудники территориальных органов уголовно-исполнительной системы, органов внутренних дел, прокуратуры и суда, а также зарубежные ученые.

The Vologda Institute of Law and Economics of the Federal Penitentiary Service organized and held a scientific-practical conference «The penitentiary system of Russia in the modern conditions of the development of society: from the paradigm of punishment to correction and resocialization». The main goal of the event was a comprehensive analysis of the problems of the modern penitentiary system in Russia. More than 200 highly qualified specialists took part in the conference. Among them are representatives of scientific organizations of the penitentiary system, faculty of departmental universities, the central office of the Federal Penitentiary Service of Russia, employees of the territorial bodies of the penitentiary system, internal affairs bodies, prosecutors and courts, as well as foreign scientists.
A Comparative Analysis of Energy And Health Sector Firm R&D Activity in Wales
Authors: Thomas Brychan , Murphy Lyndon , Miller Christopher
Published: December 2022

Given the current levels and future requirements of R&D in Wales this paper focuses on the Welsh Government (WG) priority areas of energy and health sector firms. In the light of current knowledge of R&D levels it considers: (i) the future requirements of R&D in Wales in terms of economic strategies and industrial trends, and (ii) the specific R&D needs of the energy and health sectors for the development of research policy for Wales. To facilitate this, the research draws on a number of research methods, including secondary data analysis and surveys. It appears that there is a need for selectivity and concentration of resources into those sectors such as energy and health where Wales has a critical mass of research and resources which have the potential for development at a World class level. The current levels of research activity in these areas can be increased if the right R&D decisions are made. In relation to this potential there are certain R&D requirements in these sectors that need to be met. These are reported in the research findings of the study undertaken into the energy and health sectors described in this paper.
Time Wave Function of the Universe
Authors: Musha Takaaki
Published: December 2022

Hartle and Hawaking have obtained expression for the wave function of Universe, using path integral technique. Instead of path integral technique, the author presents an alternative way of calculating the wave function of the Universe by using the Schrodinger equation. From which, it can be seen that there are two time flows of the Universe which travel in opposite direction along the time line. This result may solve the riddle that there is strong evidence that the observable universe is composed almost entirely of ordinary matter, as opposed to an equal mixture of matter and antimatter.
UV Disinfectant Médium
Authors: Carreño Estefania Moreno , Vázquez Ernesto Mendoza , Moredia Moisés Sánchez
Published: December 2022

The objective was to design and create an airtight environment that disinfects objects and inactivates microorganisms with radiation, in addition to being easy to use and at a low cost. With a metallic structure, acrylic paint coatings, an acrylic sheet and a UV light lamp, which is controlled with a radiation sensor and another movement sensor. To be able to disinfect the interior of the box allowing to inactivate microorganisms at a low cost and easy handling. When using radiation as a disinfectant, microorganisms do not generate resistance and it is an easy- to-use method. The design was based on equipment used to disinfect, the design was carried out in design software, then an analysis of materials for its construction was carried out, taking into account radiation and other variables such as temperature. The results were the analysis of the correct function of the seals in the box, the power of the radiation to inactivate and the easy handling of the equipment.
Characteristics and Clinical Description of Breast Cancer Patients in Sanjiwani General Hospital at Gianyar
Authors: Ekassiana Pande Made Krisna , Widiana I Gede Tuban Eling Tulus , Yasa I Nyoman Wawan Tirtha
Published: December 2022

Backgrounds: Breast cancer is the uncontrolled growth of breast cells. The number of new breast cancer cases reached 68,858 cases (16.6%) of the total 396,914 new cancer cases in Indonesia, while the number of deaths reached 22 thousand cases. The rate of breast cancer in Bali ranks first in the most common types of cancer in women. aim: Knowing the characteristics and clinical features of breast cancer patients at the Sanjiwani General Hospital in Gianyar from January to December 2021. Methods: This study uses a descriptive design to describe or make a description of a condition or situation objectively. This study will use secondary data from medical records at the Sanjiwani Hospital Gianyar, including age, parity, family history, menopausal status, chief complaint, tumor size, metastasis, histopathological type, and breast cancer subtype. Data analysis used univariate data. Results: 116 confirmed breast cancer patients mean age 49.85±9.89 years, multipara 75.9%, without a family history, 97.4%, premenopausal and menopause status are the same, most complaints are lumps 45.7%, T4 size 55.2 %, lymph nodes with positive nodules 71.6%, without metastases 91.4&, typeInvasive carcinoma of no special type grade 2 38.8%, and luminal subtype B Her 2- 37.9%. Conclusion: Most of them are middle-aged, without a family history, with complaints coming because of lumps, T4 size with positive nodules without metastases, most are Invasive carcinoma of no special type grade 2 and subtypeLuminal B Her 2 (-).
A Positive Attitude Practice: The Best Solution to Mitigate Water Pollution
Authors: Pin Chua Boon
Published: December 2022

The attitude of human create pollution. Pollution has to be addressed, and changing of human attitudes could be the only way to mitigate the pollution. The three pillars method to encourage humans to change their attitude so that our environment will at least maintain the strata quo of the current situation. The process of changing the human attitude is a long-term and time- consuming process, however, the end result is an encouraging one. The two examples quoted are the River of Life Project and the Sungai Way River rehabilitation project. Both projects have significant success stories of changing human attitudes. The first example is that the government has spent a lot of money to beautify and clean the river, an expensive clean-up, but it creates an awareness that is time for humans need to change their attitude to keep the environment clean (the application of Utilitarian attitude approach). The second example is the involvement of stakeholders, such as communities, students, teachers, merchants, factory owners, and traders. Who are knees to rehabilitate the river that flows beside their place of work, properties, residential area, schools, and playground (a good application of Normative Attitude). The environment can be reinstated to its natural state when humans change their attitude of habituation.
Beta Cell Death Mechanism in Type 2 Diabetes: An Overview
Authors: Siagian Mikhael Akbar Rizky , Tazkira Bellinda Zalzabillah , Herawati Lilik
Published: December 2022

Beta cell failure is central to the development and progression of type 2 diabetes (T2D). This article examines the mechanism of beta cell death in T2D. Chronic hyperglycemia and hyperlipidemia are toxic to beta cells and progressively lead to apoptosis. It is triggered by metabolic alterations such as glucotoxicity, lipotoxicity, inflammation, endoplasmic reticulum (ER) stress, mitochondrial dysfunction and oxidative stress. Our review focuses on the apoptosis of beta cell induced by hyperglycemia, hyperlipidemia, beta cell fatigue, and inflammation. This review may suggest areas for future research on the therapeutic options for protecting beta cell function/mass by targeting various underlying factors and mechanisms with a role in disease progression.
Globalization in Egypt in Historical Context: “Globalization, Transnational Mobilities, and the Local in Ancient Egypt”
Authors: Ead Hamed Abdelreheem
Published: December 2022

The historical beginnings of globalization are still being debated. Though many experts believe globalization began in the modern period, others believe it has a lengthy history. Globalization is as old as humanity. Since the dawn of recorded history, major characters such as emperors, explorers, traders, and preachers have traveled in an attempt to grow their political authority, better their standard of living, convert their beliefs, or simply satisfy human curiosity. They traded four major ingredients through varied contacts, experiences, and collisions: people, thoughts, money, and resources. This paper aims to describe the historical process of development and demonstrate that globalization is not a new phenomenon, but rather as old as civilization itself. With each material, scientific, and technological advancement, the velocity of change increased, causing globalization to spread to new and distant locations. This article, which is part of a series named “Globalization in Egypt in a Historical Context”(1-6), discusses globalization in ancient Egypt. Globalization has existed in Old Egypt since the establishment of economic relations between it and the ancient near world, when commercialized urban centers were predominantly oriented around the axis of Egyptian culture, as well as a wide range from Egypt to cities such as Alexandria, Athens, and others. During that time, trade was common, and the concept of cosmopolitan culture evolved for the first time. Egypt, with its lengthy and complicated population history, provides an ideal location for studying population movements. This article investigates key shifts in global relations beginning in 3000 CE and identifies the major turning moments that hastened the progress of globalization inside ancient Egypt.
Pengaruh Bimbingan Perwalian Dan Sikap Taruna Pada Bimbingan Perwalian Terhadap Prestasi Belajar Taruna
Authors: Purwantono
Published: December 2022

This research has been entitled the use of representative practice and cadet attitude at practice to study achievement level of PIP Semarang cadet. The problem taken in this research is to find out if there was any effect between the study achievement PIP Semarang cadet to the use of representative practice and the cadet’s attitude at practice. To answer that problem, the sample used is 50 cadet’s from 220 cadet populations taken stratified random sampling. The analysis system used in this research is validity, reliability, and moment product correlation. The analyst result shows that representative practice frequency is not enough yet, because the average frequency of practice is just once a month. The relation between practice periods to cadet’s study achievement is 0,254 which means there is any relation although it’s so small rate.Penelitian ini berjudul Pengaruh tingkat penerapan peranan bimbingan perwalian dan sikap taruna pada bimbingan perwalian terhadap prestasi belajar taruna PIP Semarang Permasalahan yang diangkat dalam penelitian ini adalah untuk mengetahui apakah ada pengaruh antara prestasi belajar taruna Politeknik Ilmu Pelayaran Semarang terhadap penerapan bimbingan perwalian dan sikap taruna terhadap bimbingan. Untuk menjawab permasalahan tersebut, sampel yang digunakan adalah 50 orang dari populasi 220 taruna yang diambil secara stratified random sampling. Analisa yang digunakan dalam penelitian ini adalah : uji validitas, reliabilitas, korelasi product moment. Hasil analisa menunjukkan bahwa frekuensi bimbingan perwalian belum mencukupi karena rata-rata frekuensi bimbingan baru satu kali dalam satu bulan. Hubungan antara lama waktu bimbingan dengan prestasi belajar taruna adalah 0,254 yang berarti terdapat hubungan meskipun tingkat hubungannya sangat kecil.