bluuebunny/crossref_metadata_2025 huggingface dataset:
Nanogenerator-Based Sensors for Energy Harvesting From Cardiac Contraction
Authors: Al-Suhaimi Ebtesam Abdullah , Aljafary Meneerah Abdulrahman , Alfareed Tahani M. , Alshuyeh Hussah Abdullah , Alhamid Galyah Mohammed , Sonbol Bayan , Almofleh Atheel , Alkulaifi Fadwa Mohammed , Altwayan Reham Khalid , Alharbi Jamilah Naif , Binmahfooz Noha Mubarak , Alhasani Eman Saleh , Tombuloglu Huseyin , Rasdan Alia Saeed , lardhi Amer A. , Baykal Abdulhadi , Homeida A. M.
Published: May 2022

Biomedical electric devices provide great assistance for health and life quality. However, their maintainable need remains a serious issue for the restricted duration of energy storage. Therefore, scientists are investigating alternative technologies such as nanogenerators that could harvest the mechanical energy of the human heart to act as the main source of energy for the pacemaker. Cardiac contraction is not a source for circulation; it utilizes body energy as an alternative energy source to recharge pacemaker devices. This is a key biomedical innovation to protect patients’ lives from possible risks resulting from repeated surgery. A batteryless pacemaker is possible via an implantable energy collecting tool, exchanging the restriction of the current batteries for a sustainable self-energy resource technique. In this context, the physiology of heart energy in the preservation of blood distribution pulse generation and the effects of cardiac hormones on the heart’s pacemaker shall be outlined. In this review, we summarized different technologies for the implantable energy harvesters and self-powered implantable medical devices with emphasis on nanogenerator-based sensors for energy harvesting from cardiac contraction. It could conclude that recent hybrid bio-nanogenerator systems of both piezoelectric and triboelectric devices based on biocompatible biomaterials and clean energy are promising biomedical devices for harvesting energy from cardiac and body movement. These implantable and wearable nanogenerators become self-powered biomedical tools with high efficacy, durability, thinness, flexibility, and low cost. Although many studies have proven their safety, there is a need for their long-term biosafety and biocompatibility. A further note on the biocompatibility of bio-generator sensors shall be addressed.
Integrating Environmental Protection and Sustainable Waste Practices Among the Communities in Higher Education Institutions: Case Study in a Malaysian University
Authors: Chan Siok Sin , Ng Theam Foo , Hassan Mohd Sayuti , Ying Chee Keat , Tan Mei Lan , Mohd Radzi Siti Fairuz , Abou Assi Reem , Chan Siok-Yee
Published: May 2022

This work is reporting the advocation of a public Malaysia University for the environmental protection through sustainable waste practices ever since its ban on the use of the “White Coffin” initiative in circa 2008, a flagship for environmental activism on its different campuses targeting to get rid of polystyrene containers. This initiative was not halted but served as a spark of flare for a sustainability journey up to this very day. The effort to realise a sustainable tomorrow as the vision of higher education sector, including the studied Malaysian University has been integrating efforts from various parties. This includes the formation of “Kampus Sejahtera” (wellness campus), regional centre of expertise, sustainability course, and more recently the sustainability month, sustainability network, and most importantly, the local NGO-industrial-academia collaboration in the path toward a sustainable tomorrow. The work in this article delineates a case study in implementing sustainable waste practice from the start to the status, in one of the Malaysian public universities which is ranked 39th in Times Higher Education University in Global Impact Ranking 2021, and top in Malaysia. More emphasis will be placed on the current initiative of the local NGO-industrial-academia collaboration as case study in the midst of the COVID-19 pandemic.
Tracking SARS-CoV-2 Variants Using a Rapid Typification Strategy: A Key Tool for Early Detection and Spread Investigation of Omicron in Argentina
Authors: Castro Gonzalo M. , Sicilia Paola , Bolzon María Laura , Lopez Laura , Barbás María Gabriela , Pisano María Belén , Ré Viviana E.
Published: May 2022

SARS-CoV-2 variants of concern (VOC) and interest (VOI) present mutations in reference to the original virus, being more transmissible. We implemented a rapid strategy for the screening of SARS-CoV-2 VOC/VOIs using real time RT-PCR and performed monitoring and surveillance of the variants in our region. Consecutive real-time RT-PCRs for detection of the relevant mutations/deletions present in the Spike protein in VOC/VOIs (TaqMan™ SARS-CoV-2 Mutation Panel, Applied Biosystems) were implemented. A total of 6,640 SARS-CoV-2 RNA samples (Cts < 30) from infected individuals in Central Argentina during 2021 were analyzed using different algorithms that were gradually adapted to the changing scenarios of local variant circulation. The strategy developed allowed the early detection and the identification of VOC/VOIs that circulated through the year, with a 100% of concordance with the WGS. The analyses of the samples showed introductions of VOCs Alpha and Gamma in February and March 2021, respectively. Gamma showed an exponential increase, with a peak of detection in July (72%), being responsible of the second wave of COVID19 in Argentina. Since VOC Delta entered into the region, it increased gradually, together with VOI Lambda, replacing VOC Gamma, until being the main variant (84.9%) on November. By December, these variants were replaced by the emergent VOC Omicron in a term of 2 weeks, producing the third wave. We report a useful tool for VOC/VOI detection, capable to quickly and cost-effectively monitor currently recognized variants in resource-limited settings, which allowed to track the recent expansion of Omicron in our region, and contributed to the implementation of public health measures to control the disease spread.
Artificial Intelligence for the Estimation of Visual Acuity Using Multi-Source Anterior Segment Optical Coherence Tomographic Images in Senile Cataract
Authors: Ahn Hyunmin , Jun Ikhyun , Seo Kyoung Yul , Kim Eung Kweon , Kim Tae-im
Published: May 2022

Purpose

To investigate an artificial intelligence (AI) model performance using multi-source anterior segment optical coherence tomographic (OCT) images in estimating the preoperative best-corrected visual acuity (BCVA) in patients with senile cataract.

Design

Retrospective, cross-instrument validation study.

Subjects

A total of 2,332 anterior segment images obtained using swept-source OCT, optical biometry for intraocular lens calculation, and a femtosecond laser platform in patients with senile cataract and postoperative BCVA ≥ 0.0 logMAR were included in the training/validation dataset. A total of 1,002 images obtained using optical biometry and another femtosecond laser platform in patients who underwent cataract surgery in 2021 were used for the test dataset.

Methods

AI modeling was based on an ensemble model of Inception-v4 and ResNet. The BCVA training/validation dataset was used for model training. The model performance was evaluated using the test dataset. Analysis of absolute error (AE) was performed by comparing the difference between true preoperative BCVA and estimated preoperative BCVA, as ≥0.1 logMAR (AE≥0.1) or <0.1 logMAR (AE<0.1). AE≥0.1was classified into underestimation and overestimation groups based on the logMAR scale.

Outcome Measurements

Mean absolute error (MAE), root mean square error (RMSE), mean percentage error (MPE), and correlation coefficient between true preoperative BCVA and estimated preoperative BCVA.

Results

The test dataset MAE, RMSE, and MPE were 0.050 ± 0.130 logMAR, 0.140 ± 0.134 logMAR, and 1.3 ± 13.9%, respectively. The correlation coefficient was 0.969 (p< 0.001). The percentage of cases with AE≥0.1was 8.4%. The incidence of postoperative BCVA > 0.1 was 21.4% in the AE≥0.1group, of which 88.9% were in the underestimation group. The incidence of vision-impairing disease in the underestimation group was 95.7%. Preoperative corneal astigmatism and lens thickness were higher, and nucleus cataract was more severe (p< 0.001, 0.007, and 0.024, respectively) in AE≥0.1than that in AE<0.1. The longer the axial length and the more severe the cortical/posterior subcapsular opacity, the better the estimated BCVA than the true BCVA.

Conclusions

The AI model achieved high-level visual acuity estimation in patients with senile cataract. This quantification method encompassed both visual acuity and cataract severity of OCT image, which are the main indications for cataract surgery, showing the potential to objectively evaluate cataract severity.
The Gut Microbiome in Parkinson’s Disease: A Longitudinal Study of the Impacts on Disease Progression and the Use of Device-Assisted Therapies
Authors: Lubomski Michal , Xu Xiangnan , Holmes Andrew J. , Muller Samuel , Yang Jean Y. H. , Davis Ryan L. , Sue Carolyn M.
Published: May 2022

Background

Altered gut microbiome (GM) composition has been established in Parkinson’s disease (PD). However, few studies have longitudinally investigated the GM in PD, or the impact of device-assisted therapies.

Objectives

To investigate the temporal stability of GM profiles from PD patients on standard therapies and those initiating device-assisted therapies (DAT) and define multivariate models of disease and progression.

Methods

We evaluated validated clinical questionnaires and stool samples from 74 PD patients and 74 household controls (HCs) at 0, 6, and 12 months. Faster or slower disease progression was defined from levodopa equivalence dose and motor severity measures. 19 PD patients initiating Deep Brain Stimulation or Levodopa-Carbidopa Intestinal Gel were separately evaluated at 0, 6, and 12 months post-therapy initiation.

Results

Persistent underrepresentation of short-chain fatty-acid-producing bacteria, Butyricicoccus, Fusicatenibacter, Lachnospiraceae ND3007 group, and Erysipelotrichaceae UCG-003, were apparent in PD patients relative to controls. A sustained effect of DAT initiation on GM associations with PD was not observed. PD progression analysis indicated that the genus Barnesiella was underrepresented in faster progressing PD patients at t = 0 and t = 12 months. Two-stage predictive modeling, integrating microbiota abundances and nutritional profiles, improved predictive capacity (change in Area Under the Curve from 0.58 to 0.64) when assessed at Amplicon Sequence Variant taxonomic resolution.

Conclusion

We present longitudinal GM studies in PD patients, showing persistently altered GM profiles suggestive of a reduced butyrogenic production potential. DATs exerted variable GM influences across the short and longer-term. We found that specific GM profiles combined with dietary factors improved prediction of disease progression in PD patients.
The Mesoscopic Connectome of the Cholinergic Pontomesencephalic Tegmentum
Authors: Zhao Peilin , Wang Huading , Li Anan , Sun Qingtao , Jiang Tao , Li Xiangning , Gong Hui
Published: May 2022

The pontomesencephalic tegmentum, comprising the pedunculopontine nucleus and laterodorsal tegmental nucleus, is involved in various functions via complex connections; however, the organizational structure of these circuits in the whole brain is not entirely clear. Here, combining viral tracing with fluorescent micro-optical sectional tomography, we comprehensively investigated the input and output circuits of two cholinergic subregions in a continuous whole-brain dataset. We found that these nuclei receive abundant input with similar spatial distributions but with different quantitative measures and acquire similar neuromodulatory afferents from the ascending reticular activation system. Meanwhile, these cholinergic nuclei project to similar targeting areas throughout multiple brain regions and have different spatial preferences in 3D. Moreover, some cholinergic connections are unidirectional, including projections from the pedunculopontine nucleus and laterodorsal tegmental nucleus to the ventral posterior complex of the thalamus, and have different impacts on locomotion and anxiety. These results reveal the integrated cholinergic connectome of the midbrain, thus improving the present understanding of the organizational structure of the pontine-tegmental cholinergic system from its anatomical structure to its functional modulation.
Focused Ultrasound Promotes the Delivery of Gastrodin and Enhances the Protective Effect on Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease
Authors: Wang Yuhong , Luo Kaixuan , Li Junrui , Liao Yehui , Liao Chengde , Chen Wen-Shiang , Chen Moxian , Ao Lijuan
Published: May 2022

Parkinson’s disease (PD) is the second most common chronic neurodegenerative disease globally; however, it lacks effective treatment at present. Focused ultrasound (FUS) combined with microbubbles could increase the efficacy of drug delivery to specific brain regions and is becoming a promising technology for the treatment of central nervous system diseases. In this study, we explored the therapeutic potential of FUS-mediated blood–brain barrier (BBB) opening of the left striatum to deliver gastrodin (GAS) in a subacute PD mouse model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The concentration of GAS in the left hemisphere was detected by ultra-high performance liquid chromatography electrospray Q-Orbitrap mass spectrometry (UHPLC/ESI Q-Orbitrap) and the distribution of tyrosine hydroxylase (TH) neurons was detected by immunohistochemical staining. The expression of TH, Dopamine transporter (DAT), cleaved-caspase-3, B-cell lymphoma 2 (Bcl-2), brain-derived neurotrophic factor (BDNF), postsynaptic density protein 95 (PSD-95), and synaptophysin (SYN) protein were detected by western blotting. Analysis showed that the concentration of GAS in the left hemisphere of PD mice increased by approximately 1.8-fold after the BBB was opened. FUS-mediated GAS delivery provided optimal neuroprotective effects and was superior to the GAS or FUS control group. In addition, FUS enhanced GAS delivery significantly increased the expression of Bcl-2, BDNF, PSD-95, and SYN protein in the left striatum (P < 0.05) and reduced the levels of cleaved-caspase-3 remarkably (P = 0.001). In conclusion, the enhanced delivery by FUS effectively strengthened the protective effect of GAS on dopaminergic neurons which may be related to the reinforcement of the anti-apoptotic activity and the expression of synaptic-related proteins in the striatum. Data suggests that FUS-enhanced GAS delivery may represent a new strategy for PD treatment.
Cerebral Blood Flow and Other Predictors of Responsiveness to Erenumab and Fremanezumab in Migraine—A Real-Life Study
Authors: Nowaczewska Magdalena , Straburzyński Marcin , Waliszewska-Prosół Marta , Meder Grzegorz , Janiak-Kiszka Joanna , Kaźmierczak Wojciech
Published: May 2022

Introduction

Monoclonal antibodies (mAbs) showed efficacy in migraine prevention. The aim of this study was to check if baseline clinical parameters and cerebral blood flow (CBF) measured by transcranial Doppler (TCD) may help predict mAbs efficacy.

Methods

Electronic charts of migraineurs treated with erenumab or fremanezumab, with baseline TCD evaluations were collected, including data on migraine type, pain localization, monthly migraine days (MMD), medication overuse headache (MOH), mean blood flow velocity (Vm), and pulsatility index (PI) in cerebral arteries.

Results

A total of 123 patients were enrolled, mean age 38, 75 years, 87 with chronic migraine, 61 with MOH, 72 were good responders (GR), and reported ≥50% reduction in MMD, 43 ≥75% reduction in MMD. Baseline Vm values in MCAs were significantly lower in GR as compared with non-responders. MAbs responsiveness ≥50% was positively associated with unilateral pain localization (OR: 6.53, 95% CI: 2.01–23.93; p = 0.003) and HIT-6 score (OR: 1.14, 95% CI: 1.01–1.30; p = 0.036) whereas negatively associated with Vm in right MCA (OR: 0.96, 95% CI: 0.92–0.99; p = 0.012), and having no relatives with migraine (OR: 0.40, 95% CI: 0.16–0.95; p = 0.040).

Conclusions

Baseline Vm in MCA is lower in mAbs GR as compared with non-responders which may reflect increased secretion of CGRP with further vasodilation in GR. Simple clinical features and baseline CBF in anterior circulation might help to predict the patient's responsiveness.
Change in Latent Gray-Matter Structural Integrity Is Associated With Change in Cardiovascular Fitness in Older Adults Who Engage in At-Home Aerobic Exercise
Authors: Polk Sarah E. , Kleemeyer Maike M. , Köhncke Ylva , Brandmaier Andreas M. , Bodammer Nils C. , Misgeld Carola , Porst Johanna , Wolfarth Bernd , Kühn Simone , Lindenberger Ulman , Wenger Elisabeth , Düzel Sandra
Published: May 2022

In aging humans, aerobic exercise interventions have been found to be associated with more positive or less negative changes in frontal and temporal brain areas, such as the anterior cingulate cortex (ACC) and hippocampus, relative to no-exercise control conditions. However, individual measures such as gray-matter (GM) probability may afford less reliable and valid conclusions about maintenance or losses in structural brain integrity than a latent construct based on multiple indicators. Here, we established a latent factor of GM structural integrity based on GM probability assessed by voxel-based morphometry, magnetization transfer saturation, and mean diffusivity. Based on this latent factor, we investigated changes in structural brain integrity during a six-month exercise intervention in brain regions previously reported in studies using volumetric approaches. Seventy-five healthy, previously sedentary older adults aged 63–76 years completed an at-home intervention study in either an exercise group (EG;n= 40) or in an active control group (ACG;n= 35). Measures of peak oxygen uptake (VO2peak) taken before and after the intervention revealed a time-by-group interaction, with positive average change in the EG and no reliable mean change in the ACG. Significant group differences in structural brain integrity changes were observed in the right and left ACC, right posterior cingulate cortex (PCC), and left juxtapositional lobule cortex (JLC). In all instances, average changes in the EG did not differ reliably from zero, whereas average changes in the ACG were negative, pointing to maintenance of structural brain integrity in the EG, and to losses in the ACG. Significant individual differences in change were observed for right ACC and left JLC. Following up on these differences, we found that exercising participants with greater fitness gains also showed more positive changes in structural integrity. We discuss the benefits and limitations of a latent-factor approach to changes in structural brain integrity, and conclude that aerobic fitness interventions are likely to contribute to brain maintenance in old age.
Pediatric Responses to Fundamental and Formant Frequency Altered Auditory Feedback: A Scoping Review
Authors: Coughler Caitlin , Quinn de Launay Keelia L. , Purcell David W. , Oram Cardy Janis , Beal Deryk S.
Published: May 2022

Purpose

The ability to hear ourselves speak has been shown to play an important role in the development and maintenance of fluent and coherent speech. Despite this, little is known about the developing speech motor control system throughout childhood, in particular if and how vocal and articulatory control may differ throughout development. A scoping review was undertaken to identify and describe the full range of studies investigating responses to frequency altered auditory feedback in pediatric populations and their contributions to our understanding of the development of auditory feedback control and sensorimotor learning in childhood and adolescence.

Method

Relevant studies were identified through a comprehensive search strategy of six academic databases for studies that included (a) real-time perturbation of frequency in auditory input, (b) an analysis of immediate effects on speech, and (c) participants aged 18 years or younger.

Results

Twenty-three articles met inclusion criteria. Across studies, there was a wide variety of designs, outcomes and measures used. Manipulations included fundamental frequency (9 studies), formant frequency (12), frequency centroid of fricatives (1), and both fundamental and formant frequencies (1). Study designs included contrasts across childhood, between children and adults, and between typical, pediatric clinical and adult populations. Measures primarily explored acoustic properties of speech responses (latency, magnitude, and variability). Some studies additionally examined the association of these acoustic responses with clinical measures (e.g., stuttering severity and reading ability), and neural measures using electrophysiology and magnetic resonance imaging.

Conclusion

Findings indicated that children above 4 years generally compensated in the opposite direction of the manipulation, however, in several cases not as effectively as adults. Overall, results varied greatly due to the broad range of manipulations and designs used, making generalization challenging. Differences found between age groups in the features of the compensatory vocal responses, latency of responses, vocal variability and perceptual abilities, suggest that maturational changes may be occurring in the speech motor control system, affecting the extent to which auditory feedback is used to modify internal sensorimotor representations. Varied findings suggest vocal control develops prior to articulatory control. Future studies with multiple outcome measures, manipulations, and more expansive age ranges are needed to elucidate findings.
JUN and PDGFRA as Crucial Candidate Genes for Childhood Autism Spectrum Disorder
Authors: Li Heli , Wang Xinyuan , Hu Cong , Li Hao , Xu Zhuoshuo , Lei Ping , Luo Xiaoping , Hao Yan
Published: May 2022

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder, characterized by marked genetic heterogeneity. In this study, two independent microarray datasets of cerebellum of ASD were integrative analyzed by NetworkAnalyst to screen candidate crucial genes. NetworkAnalyst identified two up-regulated genes, Jun proto-oncogene (JUN) and platelet derived growth factor receptor alpha (PDGFRA), as the most crucial genes in cerebellum of ASD patients. Based on KEGG pathway database, genes associated with JUN in the cerebellum highlight the pathways of Th17 cell differentiation and Th1 and Th2 cell differentiation. Genes associated with PDGFRA in the cerebellum were found enriched in pathways in EGFR tyrosine kinase inhibitor resistance and Rap1 signaling pathway. Analyzing all differentially expressed genes (DEGs) from the two datasets, Gene Set Enrichment Analysis (GSEA) brought out IL17 signaling pathway, which is related to the expression of JUN and PDGFRA. The ImmuCellAI found the elevated expression of JUN and PDGFRA correlating with increased Th17 and monocytes suggests JUN and PDGFRA may regulate Th17 cell activation and monocytes infiltrating. Mice model of maternal immune activation demonstrated that JUN and PDGFRA are up-regulated and related to the ASD-like behaviors that provide insights into the molecular mechanisms underlying the altered IL17 signaling pathway in ASD and may enable novel therapeutic strategies.
Identification of Pathogenetic Brain Regions via Neuroimaging Data for Diagnosis of Autism Spectrum Disorders
Authors: Wang Yu , Fu Yu , Luo Xun
Published: May 2022

Autism spectrum disorder (ASD) is a kind of neurodevelopmental disorder that often occurs in children and has a hidden onset. Patients usually have lagged development of communication ability and social behavior and thus suffer an unhealthy physical and mental state. Evidence has indicated that diseases related to ASD have commonalities in brain imaging characteristics. This study aims to study the pathogenesis of ASD based on brain imaging data to locate the ASD-related brain regions. Specifically, we collected the functional magnetic resonance image data of 479 patients with ASD and 478 normal subjects matched in age and gender and used a machine-learning framework named random support vector machine cluster to extract distinctive brain regions from the preprocessed data. According to the experimental results, compared with other existing approaches, the method used in this study can more accurately distinguish patients from normal individuals based on brain imaging data. At the same time, this study found that the development of ASD was highly correlated with certain brain regions, e.g., lingual gyrus, superior frontal gyrus, medial gyrus, insular lobe, and olfactory cortex. This study explores the effectiveness of a novel machine-learning approach in the study of ASD brain imaging and provides a reference brain area for the medical research and clinical treatment of ASD.
Decision Making in Mice During an Optimized Touchscreen Spatial Working Memory Task Sensitive to Medial Prefrontal Cortex Inactivation and NMDA Receptor Hypofunction
Authors: Dexter Tyler D. , Palmer Daniel , Hashad Ahmed M. , Saksida Lisa M. , Bussey Tim J.
Published: May 2022

Working memory is a fundamental cognitive process for decision-making and is a hallmark impairment in a variety of neuropsychiatric and neurodegenerative diseases. Spatial working memory paradigms are a valuable tool to assess these processes in rodents and dissect the neurobiology underlying working memory. The trial unique non-match to location (TUNL) task is an automated touchscreen paradigm used to study spatial working memory and pattern separation processes in rodents. Here, animals must remember the spatial location of a stimulus presented on the screen over a delay period; and use this representation to respond to the novel location when the two are presented together. Because stimuli can be presented in a variety of spatial configurations, TUNL offers a trial-unique paradigm, which can aid in combating the development of unwanted mediating strategies. Here, we have optimized the TUNL protocol for mice to reduce training time and further reduce the potential development of mediating strategies. As a result, mice are able to accurately perform an enhanced trial-unique paradigm, where the locations of the sample and choice stimuli can be presented in any configuration on the screen during a single session. We also aimed to pharmacologically characterize this updated protocol, by assessing the roles of the medial prefrontal cortex (mPFC) and N-methyl-D-aspartate (NMDA) receptor (NMDAr) functioning during TUNL. Temporary inactivation of the medial prefrontal cortex (mPFC) was accomplished by directly infusing a mixture of GABA agonists muscimol and baclofen into the mPFC. We found that mPFC inactivation significantly impaired TUNL performance in a delay-dependent manner. In addition, mPFC inactivation significantly increased the susceptibility of mice to proactive interference. Mice were then challenged with acute systemic injections of the NMDAr antagonist ketamine, which resulted in a dose-dependent, delay-dependent working memory impairment. Together, we describe an optimized automated touchscreen task of working memory, which is dependent on the intact functioning of the mPFC and sensitive to acute NMDAr hypofunction. With the vast genetic toolbox available for modeling disease and probing neural circuit functioning in mice, the TUNL task offers a valuable paradigm to pair with these technologies to further investigate the processes underlying spatial working memory.
Neuroblastic Tumors of the Adrenal Gland in Elderly Patients: A Case Report and Review of the Literature
Authors: Deslarzes Philip , Djafarrian Reza , Matter Maurice , La Rosa Stefano , Gengler Carole , Beck-Popovic Maja , Zingg Tobias
Published: May 2022

Background

Neuroblastic neoplasms (NN) include ganglioneuromas (GN), ganglioneuroblastomas (GNB), and neuroblastomas (NB). They generally arise in childhood from primitive sympathetic ganglion cells. Their incidence in adults, especially among elderly, is extremely low.

Case Presentation

This is the case of a 74-year-old woman with history of abdominal pain, weakness and night sweating since several months. Blood pressure was normal. CT-scan showed a 10 cm left adrenal mass, without other pathologic findings. An open left-sided adrenalectomy was performed. Recovery was uneventful with hospital length of stay of 8 days. Based on morphological, immunohistochemical, and molecular features the diagnosis was a nodular GNB. A positron emission tomography (PET) performed 6 weeks after the resection did not show any residual tumor or distant metastases. The patient was followed-up with annual clinical and radiological exams.

Conclusion

This case presentation, associated with a review of the literature, illustrates the importance to include NN in the preoperative differential diagnosis of adrenal tumors in adults and highlights the need for multidisciplinary patient work-up and management.
The Strategies and Mechanisms of Immune Checkpoint Inhibitors for Brain Metastases in NSCLC
Authors: Li Ji , Wang Min , Xu Shuhui , Li Yuying , Li Jiatong , Yu Jinming , Zhu Hui
Published: May 2022

Brain metastases are more and more common among patients with non-small cell lung cancer (NSCLC). TKI therapy could provide ideal outcomes for patients harboring epidermal growth factor receptor or ALK mutations. For wild-type patients, however, survival is poor because there are few effective treatments other than radiotherapy. Immune checkpoint inhibitors (ICIs) have changed the management of advanced NSCLC. However, the exclusion of patients with active brain metastasis (BM) from most ICI trials precludes the generalization of results. Accordingly, a variety of appropriate real-world studies and clinical trials are being developed to evaluate tumor response. Increasingly encouraging results have suggested that ICIs could be active in the central nervous system (CNS) in select patients with high PD-L1 expression and low CNS disease burden. With the extensive use of ICIs in NSCLC patients with BM, many important questions have emerged concerning issues such as the clinical response to a single ICI, use of ICIs combined with chemotherapy or radiation, the biological mechanism and appropriate sequencing of local and systemic therapy combinations, and safety and toxicity. The present review summarizes the advances in systemic ICIs for the treatment of NSCLC patients with BM, discusses factors associated with efficacy and toxicity, and explores future directions.
Knowledge Spillover and Emotional Motivation—A Study on the Willingness and Influencing Factors of Project-Based Learning
Authors: Ren Yanyan
Published: May 2022

Project-based learning (PBL) is a task-based learning mode, which is of great significance to context-based curriculum education. With data collected through questionnaires and interviews, this article builds a binary logistic regression analysis model to explore the learners' willingness of PBL and its influencing factors. A total of 14 influencing factors are set in the research, with an innovative import of knowledge spillover and emotional motivation, to examine the impact on PBL willingness. Results show that eight factors, such as project-based learning experience, clarity of curriculum tasks, contextuality of curriculum content, and requirement for innovation of curriculum tools, have significant positive impacts on learners' willingness of PBL, while four factors, including the challenge of the curriculum project and tendency of learning objectives setting, have significant negative impacts. What's more, the grade of the learners and the challenge of the curriculum project have no significant impact. This article verifies that individual characteristics, knowledge spillover, and emotional motivation have different directions and degrees of impact on learners' willingness of PBL. Then, reasons are explored and implications proposed that these factors should be distinguished and paid sufficient attention to. Finally, suggestions are put forward on strengthening the contextuality of curriculum content, identifying the heterogeneity of learners, and expanding innovative tools to develop a PBL-based blended teaching model. In this way, the potential of PBL can be fully realized in maximizing learning achievements.
The Mental Vulnerability of Affordable Housing Residents Based on Structural Equation Model: A Case Study of Fanghe Garden in Guangzhou
Authors: Zhang Yuanyuan , Li Liling , Tang Bo , Lin Lin
Published: May 2022

By constructing a “measure-representation-mechanism” research paradigm of mental vulnerability, this manuscript explores the mental vulnerability measures, spatial representations, and influencing factors of affordable housing residents in Fanghe Garden in Guangzhou by combining the mental vulnerability questionnaire (MVQ) and the structural equation model (SEM). First, the residents of Fanghe Garden had a higher mental vulnerability, difficulties in interpersonal interaction, and lower well-being. Second, the behavioral spatial representations of residents’ mental vulnerability were significantly differentiated. Low-rent housing residents were less active and preferred hidden and small places, while economically affordable housing residents were more active, and they concentrated their activity space in the cultural gallery and central square. Residents were highly willing to interact with neighbors within the community, but mainly with similar people. Third, housing condition, community construction, physical condition, neighborhood communication, and housing experience had a significant negative effect on the mental vulnerability of affordable housing residents.
Computational Modeling of the Value Co-Creation Process in Customer Service: An Application of the NK Model
Authors: Li Xi , Sekiguchi Tomoki , Wu Jiunyan , Ye Qiongwei
Published: May 2022

There has been an increasing interest to explore and gain knowledge about customer engagement behavior among academia and practitioners. Particularly, the value co-creation process in customer services is essential to explore the interaction structure. In this study, we applied the computational simulation of the NK model to identify the value co-creation process between service employees and customers in the service context. To specifically explore the dynamic interaction among them, we identified what kind of service is provided for what type of customers and when service performance improves according to the degree of interaction between service employees and customers. The simulations show that the greatest service value can be achieved when employees and customers jointly perform local search (90%) and long jump (10%). However, if both employees and customers jointly perform local search only, the service value can be stuck in a local optimum. In cases where employees and customers make their independent improvement, either through local search or long jump, the overall service value varies depending on the complexity of interactions between employees and customers. For example, the improvement in service value is the worst when employees and customers make long jumps at independent timings in high complex interactions. Our computational simulations offer visible experimental-based insights into understanding the value co-creation process with customers and promising results for customer service studies.
Fall Seven Times, Stand Up Eight: Linking Project Management Innovation, Project Governance, and High-Performance Work Practices to Project Success
Authors: Zaman Umer , Khan Mohammad Nasar , Raza Syed Hassan , Farías Pablo
Published: May 2022

Project managers seem to be puzzled in resolving the global dilemma of project failures across industries. Hence, the present study introduces project management innovation (PMI) as a determinant of project success (PS) and explores whether project governance (PG) and high-performance work practices (HPWPs), strengthen this relationship. To confirm these propositions, study data using adapted scales were collected from project professionals representing software development companies in the emerging IT industry in Pakistan. Structural equation modeling (SEM) was employed to examine the hypothesized relationships and encourage PMI-guided solutions for project failures. SEM results statistically validated that project success is positively influenced by PMI, whereas this relationship is significantly strengthened through the moderating influence of PG and HPWPs, respectively. Theoretically, the present research is the first of its kind to introduce and empirically examine these untested relationships between PMI, PG, HPWPs, and PS in a single framework. These novel findings hold strategic value for both project managers and organizational leaders who oversee a range of project portfolios. Long-lasting advantages and superior achievements can be reinvigorated through PMI, after departure from traditional approaches and answering calls for new solutions to new problems in managing projects. Moreover, project governance and HPWPs should be reconfigured to oversee, as well as meet the special needs of each unique project.
Taking Care of Business in a Male – Dominated Drug Economy: Income Strategies, Risks, and Opportunities of Women Who Use Drugs
Authors: Richert Torkel
Published: May 2022

Background

Street level drug economies are often described as hierarchical and gender-segregated arenas where men hold high positions and control the supply of drugs, and where women are confined to marginal and low-level positions. Few studies have explored income strategies, risks and opportunities of women who use drugs within drug economies in the Nordic countries.

Objective

The aim of this study was to analyze women's stories about “taking care of business”–making money and securing drugs–in a local drug economy. The study focuses on the women's gender enactments, the strategies they use to achieve success, and the barriers and risks they face in their everyday endeavors.

Methods

This article draws on informal conversations and in-depth qualitative interviews with 27 female drug users in Malmö, Sweden during periods of fieldwork between 2009 and 2012.

Results

The interviewed women had established themselves as entrepreneurs in the local drug economy, working hard for their money. However, only a few held middle or high positions, and all women described encountering gendered obstacles and risks in their efforts to take care of business. The patriarchal and sexualized nature of the drug economy meant special prerequisites for the women's income strategies and gender enactments. Three main income strategies were distinguished in the women's stories: (1) using femininity and sexuality, (2) proving tough and dangerous by using street masculinity, and (3) establishing trust, being professional, and keeping a low profile. These strategies involved different advantages and disadvantages, as well as different types of risk.

Conclusions

The results show that it is possible for women to achieve success in male-dominated drug economies, but that this is associated with major challenges. Gendered social hierarchies, structures and norms seem to influence the women's gender enactments, opportunities and risks. However, factors such as type of drug use, degree of drug dependence and social position, was also decisive for their possibility of taking care of business. This points to the importance of combining a focus on gender with a focus on other determants of power relations and vulnerabilities, when studying the everyday lives of people who use drugs.
Epistemic Rhetoric in Virtual Reality Interactive Factual Narratives
Authors: Fisher Joshua A.
Published: May 2022

The turn to Interactive Digital Narratives to understand complexity offers a new model for creating, developing, and maintaining knowledge. At the same time, storytellers have turned their attention to Virtual Reality (VR). The confluence of these trends draws attention to how non-fiction practitioners can use the technical and aesthetic affordances of VR to create knowledge about complex subjects through the IDN form. This article explores the epistemic rhetorical nature of using narrative discourse in VR to create knowledge about a non-fiction subject. The IDN community has not addressed this rhetorical aspect in their proposed epistemological process. Clarifying the epistemic rhetorical aspect inherent in producing knowledge on complex subjects through IDN provides insights into practitioners’ persuasive and political design and development choices. These intentional choices, in turn, impact the kind of knowledge produced. This rhetorical approach to knowledge production can be grounded in a Neo-sophist epistemic tradition wherein aesthetic choices are used rhetorically. I will present and discuss the Sophist rhetorical tactics of antithesis, the rhetoric of the possible; enargeia, the rhetoric of vivid details; kairos, the rhetoric of opportune timing; and mêtis, the rhetoric of the body. Their implementation by practitioners, how these aesthetic choices rhetorically create knowledge in the System-Process-Product model is presented. The article clarifies these rhetorical processes and choices and analyzes the 2021 Tribeca Film Festival’s Best Immersive Narrative, The Changing Same: An American Pilgrimage: Episode 1. This VR factual IDN allows interactors to experience historical moments of racial injustice in the United States. The production team was interviewed about how they used the technical and aesthetic qualities of VR and IDN rhetorically to produce knowledge about the complex and violent history of racial injustice in the United States. Their responses indicate their active use of epistemic rhetorical tactics that capitalize on the technical and aesthetic affordances of VR and IDN to create knowledge.
Diets Partially Replaced With Cassava Residue Modulate Antioxidant Capacity, Lipid Metabolism, and Gut Barrier Function of Huanjiang Mini-Pigs
Authors: Azad Md. Abul Kalam , Jiang Huijiao , Ni Hengjia , Liu Yating , Huang Pan , Fang Jun , Kong Xiangfeng
Published: May 2022

Agricultural by-products have been identified as potential feed resources in animal production. The present study investigated the effects of cassava residue (CR) or fermented CR (FCR) on antioxidant capacity, immunity, gut barrier functions, and lipid metabolism in pigs. A total of 120 healthy Huanjiang mini-piglets were assigned into three groups, including control group (basal diet), CR group (basal diet + 5% CR), and FCR group (basal diet + 5% FCR). The experiment lasted for 30 days. The results showed that, dietary CR or FCR supplementation increased the jejunal catalase (CAT, P = 0.063) and glutathione peroxidase (GSH-Px, P < 0.05) levels and hepatic superoxide dismutase (SOD, P < 0.05) level while decreased (P = 0.077) ileal malondialdehyde (MDA) level, when compared with the control group. Dietary CR supplementation increased intestinal SOD and hepatic GSH-Px levels, whereas decreased jejunal and hepatic MDA levels (P < 0.05). Dietary CR supplementation increased the levels of secretory immunoglobulin A (sIgA) in the intestine and liver, as well as jejunal interleukin (IL)-10, ileal tumor necrosis factor (TNF)-α, and hepatic interferon (IFN)-γ, whereas dietary CR or FCR supplementation decreased the jejunal IL-1β level and increased hepatic IL-10 level (P < 0.05). In the intestinal microbiota analysis, dietary CR or FCR supplementation enhanced the colonic α-diversity and ileal Actinobacteria abundance, whereas decreased ileal Verrucomicrobia and colonic Tenericutes abundances (P < 0.05). In addition, dietary FCR supplementation increased Firmicutes and decreased Bacteroidetes abundances in the ileum and colon, whereas CR supplementation increased Escherichia-Shigella and decreased Terisporobacter abundances in the ileum (P < 0.05). Moreover, dietary CR or FCR supplementation up-regulated (P < 0.05) the gene expressions related to gut barrier functions of piglets. However, dietary CR supplementation showed negative impacts on hepatic lipid metabolism by up-regulating the expression of genes associated with fatty acid synthesis and triglyceride and lipid metabolism. In conclusion, dietary CR or FCR supplementation can maintain the health of piglets by increasing antioxidant capacity, gut barrier function, and altering the intestinal microbiota composition, but CR supplementation may increase the potential risk of abnormal lipid metabolism.
Adoption of Food Species Mixtures from Farmers’ Perspectives in Germany: Managing Complexity and Harnessing Advantages
Authors: Timaeus Johannes , Ruigrok Ties , Siegmeier Torsten , Finckh Maria Renate
Published: May 2022

Many agronomic studies have shown the advantages of species mixtures (SM), but for food grain production, they represent only a small niche. Empirical studies that investigate reasons for SM adoption in food grain production are scarce. Here we present an in-depth study based on qualitative expert interviews with nine farmers. By means of interpretative analysis and reconstruction, socially shared models of SM adoption were built to identify the five main factors for SM adoption: (1) perceived relative mixture performance compared to sole crops, (2) suitability within the farm context (3), challenges and opportunities in mixture management due to increased complexity, (4) knowledge and technology as resources to handle mixture management and (5) quality standards in the food value chain. Relative performance was perceived as higher for SM than for sole crops for crop protection, nutrient efficiency, farm diversification, total yield stability and grain quality. The yield stability of individual crop species in SM was perceived as lower and grain impurities higher, requiring increased separation efforts. The economic potential of SM was perceived as highly variable, depending on crop value and post-harvest efforts to attain food quality. Reconstructing the mixture management process revealed that the interspecific plant interactions and emergent mixture attributes increased the cropping system complexity and affected the entire farming process. Adopting SM required knowledge about species interactions, mixture attributes and equipment settings. Large knowledge gaps for food SM were identified. The complexity of SM also provided opportunities for farmers to design mixtures that allow competition control (alternate rows) or avoid separation (relay mixtures). The main conclusions are: (1) increased complexity is a basic property of SM compared to sole crops, enabling advantages and increasing the option space to develop new sustainable cropping systems, (2) specific knowledge and technology are required for SM and are not accessible for most farmers, requiring new information channels and (3) new food SM should be developed more systematically, taking into account mixture properties and their effects on the farming process, as well as needs from the food value chain.