bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinicopathologic and Immunophenotypic Features of Primary Intestinal Extranodal NK/T-Cell Lymphoma, Nasal Type
Authors: Fang Jian-Chen , Xia Zhao-Xia , Wang Chun-Nian , Li Zheng
Published: July 2015

Primary intestinal extranodal NK/T-cell lymphoma, nasal type, is an extremely rare type of lymphoma with poor prognosis, and early diagnosis is challenging. Here we have investigated the clinicopathologic features and immunophenotypes of primary intestinal extranodal NK/T cell lymphomas, nasal type, in 10 Chinese patients. Complete staging data showed that 1 patient had stage I disease, 7 had stage II disease, and 2 had stage III disease. Eight of 10 (80%) patients had lymphadenopathy and none had bone marrow involvement. All the patients had a low International Prognostic Index (IPI) score (<3) at presentation. The median age at the time of diagnosis was 37.5 years (range = 24-68 years). All the patients died within 21 months, and the median survival time was 9.5 months (range = 2-21 months). So the conventional IPI and staging system failed to predict the outcome of the patients with the lymphoma. Except for the size of tumor cells, most of the morphologic features of the cases we studied were similar to those involving the midline facial tissue. Immunohistochemical studies showed the expression of cytotoxic markers (100%), CD2 (100%), CD3ε (90%), CD56 (80%), P53 (60%), CD30 (30%), LMP1 (30%), EBNA3A (0%). Nine cases (90%) highly expressed Ki-67. In situ hybridization for Epstein–Barr virus–encoded small RNA was positive in all cases.
Construct and Predictive Validity of Social Acceptability
Authors: Harrison Judith R. , State Talida M. , Evans Steven W. , Schamberg Terah
Published: July 2015

The purpose of this study was to evaluate the construct and predictive validity of scores on a measure of social acceptability of class-wide and individual student intervention, the School Intervention Rating Form (SIRF), with high school teachers. Utilizing scores from 158 teachers, exploratory factor analysis revealed a three-factor (i.e., Suitability, Perceived Benefit, Convenience) structure. Findings revealed that teachers who implemented class-wide and individual student interventions with perfect integrity or less than acceptable integrity rated the interventions as less suitable than those who implemented with acceptable integrity. Similarly, the same groups rated the interventions as less convenient than those who implemented with acceptable integrity. Implications for practice and future research are discussed.
Clinical and laboratory features of cats with feline infectious peritonitis – a retrospective study of 231 confirmed cases (2000–2010)
Authors: Riemer Friederike , Kuehner Kirsten A , Ritz Susanne , Sauter-Louis Carola , Hartmann Katrin
Published: July 2015

Objectives

The objectives of this study were to review signalment, clinical signs and laboratory features in a large number of naturally occurring cases of feline infectious peritonitis (FIP), and to evaluate potential changes in diagnostic criteria for FIP and compare findings in cats with and without effusion.

Methods

The medical records of 231 cats with confirmed FIP that presented to the Clinic of Small Animal Medicine of the Ludwig-Maximilian University of Munich, Germany, were reviewed for signalment, history, and clinical and laboratory parameters. Age, sex and breed distribution of the cats were compared with the clinic population.

Results

Male sex and young age were significantly correlated with FIP. Neutering status was not associated with FIP. No breed predisposition was observed and the majority of cats presented were domestic shorthair and mixed breed. Microcytosis of peripheral erythrocytes was found in 35.1% of cats, of which 42.4% did not have concurrent anaemia. Band neutrophilia was documented in 44.3% (81/183), of which 35.8% did not have mature neutrophilia. Lymphopenia, observed significantly more often with effusion, was documented in only 26.8% of cats without effusion. Hyperbilirubinaemia also occurred significantly more often in cats with vs without effusion. While serum total protein was increased in only 17.5% of cats, hyperglobulinaemia was documented in 89.1%. Nearly 85.0% of cats had an albumin-to-globulin (A:G) ratio <0.8, while 67.8% had an A:G ratio <0.6.

Conclusions and relevance

Microcytosis was common and can increase suspicion of FIP in the presence of other typical clinical and laboratory abnormalities. The low prevalence of lymphopenia in cats without effusion suggests that this is not a useful parameter in non-effusive FIP. The frequent occurrence of a left shift in the absence of a mature neutrophilia complicates the differentiation of effusive FIP and septic peritonitis. Globulins and A:G ratio were of higher diagnostic value than hyperproteinaemia.
Impact of Renal Artery Angulation on Procedure Efficiency During Fenestrated and Snorkel/Chimney Endovascular Aneurysm Repair
Authors: Ullery Brant W. , Chandra Venita , Dalman Ronald L. , Lee Jason T.
Published: July 2015

Purpose: To determine the impact of renal artery angulation on time to successful renal artery cannulation and procedure efficiency during fenestrated and snorkel/chimney endovascular aneurysm repair (EVAR). Methods: The imaging and procedure logs of 77 patients (mean age 74.2 years; 63 men) who underwent complex EVAR (24 fenestrated, 53 snorkel/chimney) from 2009 to 2013 were reviewed. Renal artery angulation was measured on preoperative computed tomographic angiography scans. Time to renal artery cannulation was retrieved from the EVAR procedure logs and compared to preoperative renal artery angulation and other metrics of procedure efficiency (eg, procedure time, fluoroscopy time, blood loss, etc). In all, 111 renal arteries were available for renal artery angulation measurement (39 fenestrated, 72 snorkel/chimney); 22 renal cannulations were inappropriate for the comparative analyses due to concomitant visceral artery stenting (n=15), combined procedures (n=6), or unsuccessful cannulation (n=1). Results: For patients undergoing fenestrated EVAR, mean renal artery angulation was -28°±21° (range +37° to -60°), not significantly different (p=0.66) from patients receiving snorkel/chimney grafts (mean -30°±19°, range +22° to -65°). Comparative analysis using median renal artery angulation (−30° for both groups) demonstrated that renal artery cannulation during fenestrated EVAR was performed significantly faster in arteries with less downward (≥ −30°) angulation (16.0 vs 32.8 minutes, p=0.04), whereas cannulation in snorkel/chimneys was faster in arteries with greater downward (< −30°) angulation (10.9 vs 17.3 minutes, p=0.05). Fenestrated EVAR cases involving less downward (≥ −30°) renal artery angulation were also associated with shorter overall procedure time (187.7 vs 246.2 minutes, p=0.01) and decreased fluoroscopy time (70.3 vs 98.2 minutes, p=0.04). Immediate renal function decline, procedural complications, and postoperative issues were not associated with renal artery angulation. Conclusion: Procedural efficiency may be optimized by considering renal artery angulation as one of several objective variables used in the selection of an appropriate endovascular strategy. The fenestrated approach is more efficient with less downward angulation to the renal arteries, while the snorkel/chimney strategy is facilitated by more downward renal artery angulation.
Intraoperative Changes in Cerebrospinal Fluid Gas Tensions Reflect Paraplegia During Thoracoabdominal Aortic Surgery
Authors: Fleissner Felix , Redwan Ahmed , Bisdas Theodosios , Boeck Anna-Lena , Weissenborn Karin , Haverich Axel , Teebken Omke E. , Pichlmaier Maximilian , Martens Andreas
Published: July 2015

Background:

In this study, gas tensions in cerebrospinal fluid (CSF) were prospectively evaluated as intraoperative markers for the detection of neurological deficits.

Methods:

Spinal fluid, serum, and heart lung machine (HLM) perfusate were monitored for gas tensions (po2/pCo2) and related parameters (pH, lactate, and glucose) during thoracoabdominal aortic repair and correlated with perioperative neurological examination and electrophysiological testing.

Results:

Forty-seven patients were assessed for the study, and 40 consecutive patients were finally included. The patients were divided into 3 groups: group A (23 patients, 57.5%): no clinical or laboratory signs of neurological damage; group B (14 patients, 35%) who developed subclinical deficits; and group C (3 patients, 7.5%) who had paraplegia. Significant intraoperative changes in CSF gas tensions were observed with postoperative paraplegia. Glucose ratio between serum and CSF showed higher variability in group C, confirming a damage of the blood–brain barrier (BBB).

Conclusion:

Major neurological damage is reflected by early changes in CSF gas tensions and glucose variability, suggesting damage of the BBB in these patients.
Platelet activation after endovascular repair of abdominal aortic aneurysm
Authors: Arnaoutoglou Eleni , Kouvelos George , Papa Nektario , Karamoutsios Achilleas , Bouris Vasilios , Vartholomatos George , Matsagkas Miltiadis
Published: July 2015

Aim

To investigate the effect of endovascular aneurysm repair (EVAR) on platelet (PLT) function and reveal possible associated factors.

Methods

Fifty consecutive patients were included. PLT count and activation (CD62P-CD36), white blood cell (WBC) count, and high sensitivity C-reactive protein (hs-CRP) were measured preoperatively, at the first and third postoperative day.

Results

EVAR elicited a significant reduction in PLT count from baseline to first day after EVAR ( p < 0.001), while no significant difference was noted between the first and third day. Furthermore, CD62P expression was markedly elevated at the first day after EVAR (median % positive PLTs from 13.7 at baseline to 22.1, p = 0.05), but returned to baseline levels by the third day. Maximum abdominal aortic aneurysm diameter was the only factor that significantly affected the CD62P values ( p = 0.005). Postoperative CD36 values were significantly correlated with total aneurysm volume ( p = 0.05) and were higher in endografts made from polyester ( p = 0.01). There were no correlation between PLT activation and hs-CRP, WBC, maximum temperature, and 30-day morbidity.

Conclusion

EVAR has elucidated a significant reduction in PLT count and increase in PLT activation at the immediate postoperative period. The type of the endograft material and the aneurysm maximum diameter and volume appear to play an important role in PLT activation.
Scapular dyskinesis: the surgeon’s perspective
Authors: Roche Simon J , Funk Lennard , Sciascia Aaron , Kibler W Ben
Published: July 2015

The scapula fulfils many roles to facilitate optimal function of the shoulder. Normal function of the shoulder joint requires a scapula that can be properly aligned in multiple planes of motion of the upper extremity. Scapular dyskinesis, meaning abnormal motion of the scapula during shoulder movement, is a clinical finding commonly encountered by shoulder surgeons. It is best considered an impairment of optimal shoulder function. As such, it may be the underlying cause or the accompanying result of many forms of shoulder pain and dysfunction. The present review looks at the causes and treatment options for this indicator of shoulder pathology and aims to provide an overview of the management of disorders of the scapula.
Intrinsic Frequency and the Single Wave Biopsy
Authors: Petrasek Danny , Pahlevan Niema M. , Tavallali Peyman , Rinderknecht Derek G. , Gharib Morteza
Published: July 2015

Insulin resistance is the hallmark of classical type II diabetes. In addition, insulin resistance plays a central role in metabolic syndrome, which astonishingly affects 1 out of 3 adults in North America. The insulin resistance state can precede the manifestation of diabetes and hypertension by years. Insulin resistance is correlated with a low-grade inflammatory condition, thought to be induced by obesity as well as other conditions. Currently, the methods to measure and monitor insulin resistance, such as the homeostatic model assessment and the euglycemic insulin clamp, can be impractical, expensive, and invasive. Abundant evidence exists that relates increased pulse pressure, pulse wave velocity (PWV), and vascular dysfunction with insulin resistance. We introduce a potential method of assessing insulin resistance that relies on a novel signal-processing algorithm, the intrinsic frequency method (IFM). The method requires a single pulse pressure wave, thus the term “ wave biopsy.”
Suvorexant in insomnia: efficacy, safety and place in therapy
Authors: Rhyne Danielle N. , Anderson Sarah L.
Published: July 2015

Insomnia is a highly prevalent disorder that can occur in conjunction with other medical or psychiatric conditions or can occur in the absence of a coexisting disorder. Regardless, treatment of insomnia is beneficial to the patient and may benefit comorbidities if they exist. Nonpharmacologic modalities such as sleep hygiene and stimulus controls are important mainstays of insomnia therapy, but may not be sufficient to treat the disorder. Dual orexin receptor antagonists (DORAs) are a new class of insomnia medication that target wakefulness-promoting neuropeptides to regulate the sleep–wake cycle. Suvorexant is the first DORA to be approved and has demonstrated efficacy at decreasing both time to sleep onset and increasing total sleep time compared with placebo. Suvorexant has a novel mechanism of action and may represent an alternative for patients who cannot tolerate or do not receive benefit from traditional sleep agents. Suvorexant is generally effective and well tolerated, but has not been compared head to head with traditional sleep agents and being only newly available, lacks a longer-term ‘real-world’ experience base.
Exploring Smoking Cessation Attitudes, Beliefs, and Practices in Occupational Health Nursing
Authors: Ganz Ollie , Fortuna Grace , Weinsier Stephanie , Campbell Kay , Cantrell Jennifer , Furmanski William L.
Published: July 2015

The purpose of this study was to explore occupational health nurses’ attitudes, beliefs, and practices regarding the delivery of smoking cessation services to workers. The study included 707 members of the American Association of Occupational Health Nurses (AAOHN) who completed a one-time survey during the fall of 2012. Results indicated that occupational health nurses believed that evidence-based treatments are at least somewhat effective and that they should provide smoking cessation services to their workers; however, a majority of occupational health nurses reported that they did not have appropriate smoking cessation training or guidelines in their workplaces. Occupational health nurses would benefit from training in the use of smoking cessation guidelines and evidence-based smoking cessation interventions, which could be used in their clinical practice. Employers should ensure that workplace policies, such as providing coverage for cessation services, facilitate smokers’ efforts to quit. Employers can benefit from many of these policies through cost savings via reduced health care costs and absenteeism.
An intelligent hospital operating room to improve patient health care
Authors: Garbey Marc , Joerger Guillaume , Huang Albert , Salmon Remi , Kim Jinsu , Sherman Vadim , Dunkin Brian , Bass Barbara
Published: July 2015

Optimizing management of multiple hospital operating rooms (ORs) is a complex problem. A large hospital can have upwards of greater than 50 with a large number of different procedures per day and per OR that needs to be scheduled several weeks in advance. Each procedure requires gathering a team led by a surgeon for a specific block of time in the OR, but even common procedures such as cholecystectomies, which account for about 1.4 million cases per year in the USA, exhibit a significant variation in total procedure duration. OR time is one of the most significant budget chapters in a modern hospital, and it has also been shown that delays in OR procedures due to lapses in scheduling and/or OR resources availability have been responsible for post-surgical complications.

We propose an innovative, cost effective hardware/software OR awareness solution that automatically (i) detects what step of the procedure the OR team is at, (ii) determines if steps are out of order, (iii) identifies and pinpoints procedural delays, irregularities, and unused OR time, and (iv) can assist in root cause analyses and assessment. Most institutions have an electronic OR management software system in place that allows for easy projection and visualization of the daily OR schedule, but all rely heavily on manual data entry resulting in human error and bias. There exists a need not only for a fully automated, unbiased, and accurate OR management system that also collects key procedural data for both real-time and retrospective analyses but also for an intuitive and user-friendly digital interface. With our system, we have been able to track and collect data on almost 300 cases to not only identify but quantify sources of inefficiency as well as automatically indicate cases that exceed expected lengths.
Rock-physics templates for clay-rich source rocks
Authors: Carcione José M. , Avseth Per
Published: July 2015

Shale source rocks are composed of various minerals, mainly smectite and illite, depending on the burial depth, and they can be described as transversely isotropic media. The “pore space” may contain kerogen, water, oil, and gas determined by the in situ conditions. A petroelastic description is based on the following: Smectite-illite transformation as a function of depth is described by a fifth-order kinetic reaction. Backus averaging to “mix” isotropic smectite and anisotropic illite is then used to obtain the elasticity constants of the mineral composing the frame. Porosity is obtained from density, and water is part of the mineral, whose elasticity constants are obtained from Gassmann equations. Oil and gas generated from kerogen are assumed to saturate the kerogen phase. The bulk modulus of the oil-gas mixture is calculated by a mesoscopic-loss model, and the stiffnesses of the kerogen/fluid mixture are obtained with the Kuster and Toksöz model, assuming that the fluid is included in a kerogen matrix. Two models are considered to obtain the seismic velocities of the shale, namely, Backus averaging and the Gassmann equation generalized to the anisotropic case with a solid pore infill. We built rock-physics templates (RPTs) containing only kerogen (immature) and kerogen plus hydrocarbons (mature). Pore-pressure effects were modeled and used as templates. We considered the Kimmeridge Shale at different depths. To model kerogen-oil and oil-gas conversions, we assumed a basin-evolution model with a constant sedimentation rate, geothermal gradient, and a first-order kinetic (Arrhenius) reaction. The detection of the hydrocarbons was investigated from RPTs, built with wave velocities, impedances, Lamé constants, density, Poisson ratio, Young modulus, and anisotropy parameters for varying kerogen content, fluid saturations, and pore pressure. Moreover, the amplitude variation with offset intercept and gradients were computed, corresponding to the seismic response of a source rock layer for varying kerogen content and fluid saturation.
Spatial sensitivity functions for rapid numerical simulation of borehole sonic measurements in vertical wells
Authors: Huang Shan , Matuszyk Paweł J. , Torres-Verdín Carlos
Published: July 2015

Borehole sonic measurements are routinely used to measure dynamic elastic properties of rock formations surrounding a wellbore. However, shoulder-bed effects, mud-filtrate invasion, and near-wellbore damage often influence the measurements and bias the interpretations. Inversion-based methods can reduce the influence of complex geometric conditions in the estimation of formation properties from sonic logs, but they require fast-forward modeling algorithms. We have developed new spatial sensitivity functions for rapid modeling of borehole sonic measurements, which were equivalent to the Green’s functions of borehole modal wave measurements. An adaptive finite-element (FE) method was used to calculate 1D axial (vertical) and 2D (axial-radial) sensitivity functions, which combined the dependence of sonic logs on the wave mode, frequency, formation properties, and logging-instrument geometry. Semianalytical formulations were also used to calculate the sensitivity functions, which involved modeling the wave propagation through an effective layered medium. The 1D axial sensitivity functions were also extended to quantify propagation properties of nondispersive modes in a borehole. Calculated semianalytical sensitivity coefficients were efficient for rapid simulation of modal frequency dispersion in the presence of a logging tool. Simulated sonic logging measurements across synthetic thinly bedded and invaded formations were compared with numerical simulations obtained with the finite-element method. Our results confirmed the efficiency, reliability, and accuracy of the approximate sonic simulation method. The maximum relative error of the rapid simulation method was consistently less than 4%, with only 2% of the central processing unit time and 2% of the memory usage compared with FE simulations.
Indication of wettability from dielectric measurements on partially saturated rocks using effective medium models
Authors: Gkortsas Vasileios-Marios , Venkataramanan Lalitha , Ramakrishnan T. S. , Freed Denise
Published: July 2015

We used two effective medium models to fit dielectric measurements on a limestone for water-wet (WW) and mixed-wet (MW) cores. The models were based on a bimodal distribution of matrix and hydrocarbon inclusions dispersed in a water host, either as one effective inclusion (bimodal model) or as separate entities (Feng-Sen bimodal). We observed that wettability has a significant effect on the shape factors of the inclusions. These shape factors were the apparent cementation factor in the bimodal and the shape factor for hydrocarbon in the Feng-Sen bimodal. The apparent cementation factor obtained in the bimodal model combined the effects of matrix and hydrocarbon in the water phase tortuosity, and we got higher values for MW than WW rocks of similar pore structure and lithology. It also varied with water saturation. The shape factor for hydrocarbon in the Feng-Sen bimodal model showed how the shape distribution of hydrocarbon affected the water phase tortuosity. It got higher values for MW than WW rocks of similar pore structure and lithology and also varied with water saturation. This variation can be interpreted as a change in the shape of the hydrocarbon ganglion. Because these shape factors are sensitive to water saturation and wettability, we need to be careful when only using them to solely interpret wettability. We expect that this study can be useful in identifying parameters from dielectric measurements that are sensitive to wettability.
Poststack, prestack, and joint inversion of P- and S-wave data for Morrow A sandstone characterization
Authors: Singh Paritosh , Davis Thomas L. , DeVault Bryan
Published: July 2015

Exploration for oil-bearing Morrow sandstones using conventional seismic data/methods has a startlingly low success rate of only 3%. The S-wave velocity contrast between the Morrow shale and A sandstone is strong compared with the P-wave velocity contrast, and, therefore, multicomponent seismic data could help to characterize these reservoirs. The SV and SH data used in this study are generated using S-wave data from horizontal source and horizontal receiver recording. Prestack P- and S-wave inversions, and joint P- and S-wave inversions, provide estimates of P- and S-wave impedances, and density for characterization of the Morrow A sandstone. Due to the weak P-wave amplitude-versus-angle response at the Morrow A sandstone top, the density and S-wave impedance estimated from joint P- and S-wave inversions were inferior to the prestack S-wave inversion. The inversion results were compared with the Morrow A sandstone thickness and density maps obtained from well logs to select the final impedance and density volume for interpretation. The P-wave impedance estimated from prestack P-wave data, as well as density and S-wave impedance estimated from prestack SV‐wave data were used to identify the distribution, thickness, quality, and porosity of the Morrow A sandstone. The stratal slicing method was used to get the P- and S-wave impedances and density maps. The S-wave impedance characterizes the Morrow A sandstone distribution better than the P-wave impedance throughout the study area. Density estimation from prestack inversion of SV data was able to distinguish between low- and high-quality reservoirs. The porosity volume was estimated from the density obtained from prestack SV-wave inversion. We found some possible well locations based on the interpretation.
Geomechanical modeling of hydraulic fractures interacting with natural fractures — Validation with microseismic and tracer data from the Marcellus and Eagle Ford
Authors: Aimene Yamina E. , Ouenes Ahmed
Published: July 2015

We have developed a new geomechanical workflow to study the mechanics of hydraulic fracturing in naturally fractured unconventional reservoirs. This workflow used the material point method (MPM) for computational mechanics and an equivalent fracture model derived from continuous fracture modeling to represent natural fractures (NFs). We first used the workflow to test the effect of different stress anisotropies on the propagation path of a single NF intersected by a hydraulic fracture. In these elementary studies, increasing the stress anisotropy was found to decrease the curving of a propagating NF, and this could be used to explain the observed trends in the microseismic data. The workflow was applied to Marcellus and Eagle Ford wells, where multiple geomechanical results were validated with microseismic data and tracer tests. Application of the workflow to a Marcellus well provides a strain field that correlates well with microseismicity, and a maximum energy release rate, or [Formula: see text] integral at each completion stage, which appeared to correlate to the production log and could be used to quantify the impact of skipping the completion stages. On the first of two Eagle Ford wells considered, the MPM workflow provided a horizontal differential stress map that showed significant variability imparted by NFs perturbing the regional stress field. Additionally, a map of the strain distribution after stimulating the well showed the same features as the interpreted microseismic data: three distinct regions of microseismic character, supported by tracer tests and explained by the MPM differential stress map. Finally, the workflow was able to estimate, in the second well with no microseismic data, its main performance characteristics as validated by tracer tests. The field-validated MPM geomechanical workflow is a powerful tool for completion optimization in the presence of NFs, which affect in multiple ways the final outcome of hydraulic fracturing.
How Do Payers Respond to Regulatory Actions? The Case of Bevacizumab
Authors: Dusetzina Stacie B. , Ellis Shellie , Freedman Rachel A. , Conti Rena M. , Winn Aaron N. , Chambers James D. , Alexander G. Caleb , Huskamp Haiden A. , Keating Nancy L.
Published: July 2015

Although insurers varied in terms of public statements regarding coverage intentions, bevacizumab use declined similarly among all payers, suggesting that provider decision making, rather than payer-specific coverage policies, drove reductions.
Cooperative interactions of LPPR/PRG family members in membrane localization and alteration of cellular morphology
Authors: Yu Panpan , Agbaegbu Chinyere , Malide Daniela A. , Wu Xufeng , Katagiri Yasuhiro , Hammer John A. , Geller Herbert M.
Published: July 2015

The lipid phosphate phosphatase-related proteins (LPPRs), alternately known as Plasticity-Related Genes (PRGs), are classified as a novel brain-enriched subclass of the lipid phosphate phosphatase (LPP) superfamily. They induce membrane protrusions, neurite outgrowth or dendritic spine formation in cell lines and primary neurons. However, the exact roles of LPPRs and the underlying mechanisms are not certain. Here, we present the results of a large-scale proteome analysis to determine LPPR1-interacting proteins using co-immunoprecipitation coupled to mass spectrometry. We identified putative LPPR1 binding proteins involved in various biological processes. Most interestingly, we identified the interaction of LPPR1 with its family member LPPR3, LPPR4 and LPPR5. Their interactions were characterized by co-immunoprecipitation and co-localization analysis using confocal and super-resolution microscopy. Moreover, co-expressing two LPPR members mutually elevated their protein levels, facilitated their plasma membrane localization and resulted in an increased induction of membrane protrusions as well as the phosphorylation of S6 ribosomal protein. Together, we revealed a novel functional co-operation between LPPR family members and discovered for the first time that LPPRs likely exert their function through forming complex with its family members.
Exercise-induced purpura – triggered by a lymphoedema
Authors: Stücker M. , Segert M. H.
Published: July 2015

Exercised-induced purpura (EIP) is an frequently misdiagnosed condition that occurs most often on the lower extremities. An association with exercise is common. Most EIP have presented in healthy-appearing individuals with no sign of chronic venous insufficiency.

A 62 year-old woman with primary lymphoedema of the right lower extremity presented erythematous purpuric patch only on her right medial ankle. This purpura had appeared spontaneously after an unusually long march without compression stockings. Through the typical history and symptoms diagnosis of exercise-induced purpura could be provided. This common and harmless disease should be known as an important differential diagnosis for systemic vasculitis.
A painful, vascularised tumour of the calf
Authors: Hoos A. , Sperhake K. , Devereux N. , Bruning G. , Beikert F. C.
Published: July 2015

The case of a 39-year old female patient, presenting a painful, well-vascularized tumour located in the subcutaneous tissue of the right calf, is reported. Due to the painfulness and tumour size progression an excision with primary wound closure (by buried sutures) was performed. The tumour showed histological features characteristic for an angioleiomyoma. Particularly middle-aged women are affected by an angioleiomyoma which represents a benign, mesenchymal tumour mostly located on the lower extremities. Differential diagnosis in painful tumours of the skin should include this entity. Because of the painfulness of the tumour primary excision is mostly recommended. In the majority of cases the diagnosis is made histologically.
Seeing and believing: recent advances in imaging cell-cell interactions
Authors: Yap Alpha S. , Michael Magdalene , Parton Robert G.
Published: July 2015

Advances in cell and developmental biology have often been closely linked to advances in our ability to visualize structure and function at many length and time scales. In this review, we discuss how new imaging technologies and new reagents have provided novel insights into the biology of cadherin-based cell-cell junctions. We focus on three developments: the application of super-resolution optical technologies to characterize the nanoscale organization of cadherins at cell-cell contacts, new approaches to interrogate the mechanical forces that act upon junctions, and advances in electron microscopy which have the potential to transform our understanding of cell-cell junctions.
O Lançamento de uma nova embalagem do refrigerante Coca-Cola: um estudo de caso sobre o lançamento da mini pet pela empresa Rio de Janeiro Refrescos
Authors: Araujo Fábio Francisco de , Adler Luciana Barata
Published: July 2015

Este estudo investigou o lançamento da embalagem de Coca-Cola Pet 250 mililitros (ml.) realizado pela empresa Rio de Janeiro Refrescos. O foco do lançamento recaiu sobre consumidores de baixa renda. Aaker (1998) descreve que a marca é composta por ativos e passivos que podem ser agrupados em cinco dimensões: lealdade, conhecimento, qualidade percebida. No caso dos consumidores de baixa renda, o interesse pode ser relacionado com aspirações sociais e sentimentos de inclusão, que vêm com o consumo das mesmas marcas consumidas pelas classes altas (Chauvel e Mattos, 2008). Prahalad (2005) destaca que criar ofertas competitivas para baixa renda permite aproveitar novas oportunidades de mercado. O método caso foi utilizado para condução da pesquisa. A adoção do estudo de caso, que preconiza o uso de múltiplas fontes de evidência, cria condições para uma triangulação dos dados durante a fase de análise (Yin, 2005). Foram realizadas entrevistas em profundidade com profissionais de marketing da empresa e de um ponto de vendas do produto. Os resultados mostram que a estratégica foi eficiente em enfrentar os concorrentes do mercado de bebidas não-alcoólicas, e que o produto foi adequado para atingir o público-alvo, pois permitiu o consumo do refrigerante Coca-Cola a um preço mais acessível.
Editorial
Authors: Moraes Joysi
Published: July 2015

Editorial
Intercultural Dialogue As a Basis for Successful Development of Modern Education and Science
Authors: Шишов  , Shishov Cergey
Published: July 2015

The article touches upon the problem of intercultural

dialogue formation in educational and scientific environment.

Intercultural dialogue is considered as a personal and social process.

Goals, objectives and forms of dialogical cooperation are defined

regarding Liminality and network environment.
Problems of the World Linguistic Landscape and Foreign Languages Teaching
Authors: Ламзин  , Lamzin Roman , Пономарев  , Ponomarev Viktor
Published: July 2015

The article reviews various interpretationsof the linguistic

view of the world.Linguistic world-images are exemplified on

terminological units, phraseological units, and proverbs of various

languages.
Old Age Rejection in Modern Culture: Myth or Reality?
Authors: Овсянникова  , Ovsyannikova Natalya
Published: July 2015

The mechanisms for making the gerontological models

in traditional and contemporary culture are described in the article.

Viewson the age in a culture are able to simulate human life and

are used by a culture subject for understanding and explaining different

situations of development, as well as its mental acceptance

or rejection. Age stereotypes reflect characteristics and properties

specified by the culture for people of certain age, and are set by the

society through traditions. Individual age differences in each culture

reflect the corresponding properties of the age layers and have their

own regulatory controls: age ceremonies.

Modern cultural approach is able to explain the phenomenon of

old age from the perspective of changing values and moral qualities

of the aging individual. The mental world of old age can accommodate

the whole system which is directly or indirectly associated

with old age and aging representations formed in both individual

and collective consciousness of culture subject.Structuring these

ideas can be performedon various bases: detaillevel; comparative

context; domination of intellectual forms; acceptance / rejection

of old age, etc.

Gerontological model in a culture can be built on actual bases:

substrate, space, time, energy, and information; while the factor of

acceptance or rejection of certain grounds of the models will be

dominant.

Acceptance or rejection of oneself in old age suggests a kind of

mental process of "trying on" certain age stereotypes by the culture

subject. The results of this process directly depend on the age potential

and individual horizons of opportunities. Ideally, each culture

subject makes a decision on what can or cannot be done

within the framework of his/her age. Cultural capacity of mentalnon-

aging lies in the strengthening of all life potentials of a "man

of culture".
Ethnic Diaspora in-between the Authorities of Two States
Authors: Адибекян  , Adibekyan Oganes
Published: July 2015

Strengthening of world nations merging together within

existing states happens along withthe formation of ethnic groups.

These foreign parts of nations form for various reasons, but independently

the associations of members of these groups have to be

in a relationship with a native country as well as with the citizens

of their country of resettlement. Self-governing bodies of the Diaspora,

authorities of native state and of the state of residence form a triangular

system, where each side holds friendliness, or hostility, or

indifference. Three components with three different attitudes form

different combinations, knowledge and consideration of which in

certain cases obtain political significance. Some views are independent

of those parties. Some are managed, generated. They are affected

by international relations in the world. Variability may Not

be excluded. All this is a subject for clarification in specific studies

of selected nations and their diaspora, selected countries. The

fundamental consideration of the positions of the Diaspora inbetween

the authorities of the two countries ismethodologically

valuable.
Family Social, Cultural and Economic Resources’ Effect on the Affordability of University Education in Russia
Authors: Куканова  , Kukanova Viktoriya , Крупеникова  , Krupenikova L.
Published: July 2015

In this article considers the factors of accessibility of

higher education in Russia. By studying the problem of accessibility

to higher education in the Russian society, it was identified two

main criteria that are important for admission to higher education:

social and cultural capital of the individual and the social and

economic potential of his family. Also, accessibility of higher education

is not only opportunity to go to university, but also to be able

to go through the entire studying period. The main difficulties

hindering the completion of education, is the difficulty in the

studying of teaching material and in adaptation to loads, it is reasons

related to the cultural capital of the family.
Polytechnic Learning in the Modern School Through the Example of Technology Lessons
Authors: Терентьев  , Terentyev Sergey
Published: July 2015

In this article the author has tried to disclose and justify

the content of the principle of polytechnic learning and its use in

the in middle school classes. Polytechnic principle of technology

learning in school is considered in the aspect of modern innovation

processes in education. The emphasis is made on the formation of

technological literacy of students as a condition and result of

Polytechnic learning. The Article reveals the essence of the principle

of polytechnic learning through teaching school children

manual labour.

The experimental part of the work shows the necessity of forming

students’ technological literacy as a condition and result of polytechnic

learning. The experimental results make it possible to pave

the trajectory for further research into the study of the conditions

necessary for increasing the level of technological literacy of learners.
Revision Knee Replacement in England and Wales: An Audit of Hospital Volume
Authors: Baker PN , Critchley RJ , Jameson S , Hodgson S , Reed MR , Gregg PJ , Deehan DJ
Published: July 2015

Increasing surgeon and hospital volume improves outcome following a range of surgical procedures, including primary and revision knee surgery. Increasing operative volume leads intuitively to greater familiarity and experience. This is particularly important for those surgeons and centres undertaking complex procedures that are often performed infrequently.
Hepatocolonic fistula: a rare consequence of retained gallstones after laparoscopic cholecystectomy
Authors: Stevens JL , Laliotis A , Gould SWT
Published: July 2015

Spillage of gallstones during laparoscopic cholecystectomy occurs in up to 30% of cases but complications due to stone retention are less frequent. We report the first case of a hepatocolonic fistula as a consequence of a retained gallstone.
La Reforma Curricular en Competencias: La Experiencia en las Preparatorias Federales por Cooperación
Authors: Silva Montes Cesar
Published: July 2015

En el presente artículo se examinan los efectos de la reforma curricular en competencias en las Preparatorias Federales por Cooperación, impulsada por la Dirección General del Bachillerato. El propósito es develar cómo el currículo en competencias para conectar a la escuela con mercado laboral, en el marco de la globalización y la sociedad del conocimiento, es incongruente con el ideal de formar ciudadanos comprometidos con la sociedad. El currículo como construcción social, representa los ideales de ser humano y sociedad en un momento histórico determinado. En el caso de Ciudad Juárez, el perfil de egreso busca ligarse con el modelo de manufactura toyotista de la industria maquiladora que exige una mano de obra adaptable, flexible y capaz de resolver problemas. El intento de ligar al bachillerato con la esfera laboral es un espejismo, porque la crisis económica, el desarrollo tecnológico y la flexibilidad laboral provocan desempleo y precariedad de las condiciones de trabajo. Otro efecto del currículo es la actualización del profesorado en la didáctica constructivista y su certificación en competencias que tecnifican su trabajo y disminuye su autonomía docente. Asimismo, al profesorado se le excluye de la definición curricular de perfiles de egreso, planes y programas de estudio, convirtiéndolo en simple ejecutor de objetivos externos. El sustento del análisis es la revisión bibliográfica y de documentos gubernamentales, más mi participación en el equipo de trabajo para la reforma curricular en 2002 y en las reuniones con directivos y funcionarios.
Escuelas de Alto y Bajo Valor Añadido. Perfiles Diferenciales de las Secundarias en Baja California
Authors: Castro-Morera Maria , García-Medina Adán Moisés , Pedroza-Zuñiga Luis Horacio , Caso-Niebla Joaquín
Published: July 2015

Los modelos contextuales de valor añadido han venido sirviendo como herramienta para el desarrollo de sistemas de evaluación basados en la rendición de cuentas (accountability). Sin embargo, el estudio de lo que aportan las escuelas una vez controladas las características contextuales relacionadas con el nivel socio-cultural de alumnos y centros(técnicamente llamadas residuos),   también puede servir para identificar y estudiar las buenas prácticas escolares de aquellos centros que promueven el desempeño de sus alumnos más allá de lo esperado por sus condiciones socio-culturales de partida. El objetivo de este artículo es describir diferenciadamente las características de estas escuelas secundarias del estado de Baja California (México). Para ello se ha utilizado la información proveniente de los instrumentos que conforman la Estrategia Evaluativa Integral durante 2010 y 2011. Los resultados muestran que las escuelas que promueven más allá de lo esperable el desempeño de sus alumnos se caracterizan porque entre los estudiantes hay niveles más altos de convivencia democrática, de sentido de pertenencia, de autorresponsabilidad y expectativas escolares; de igual manera, los docentes de Matemáticas les dan un mayor apoyo cuando los alumnos tienen dudas y les ofrecen una retroalimentación más rica. Sorprendentemente, las escuelas de alto y bajo residuo no se diferencian en el tipo de actividades que los docentes realizan con los alumnos de bajo aprovechamiento. Este artículo es una buena ilustración de los múltiples usos que se pueden dar a los modelos contextuales de valor añadido.
Konstytucyjne publiczne prawo gospodarcze
Authors: Kieres Leon
Published: July 2015

Wolność gospodarcza należy do podstawowych wartości konstytucyjnych. Podlega ona interpretacji w orzeczeniach Trybunału Konstytucyjnego jako zasada konstytucyjna i konstytucyjne prawo podmiotowe. Celem tej interpretacji jest wyznaczenie miejsca wolności gospodarczej w konstytucyjnym ujęciu społecznej gospodarki rynkowej oraz ustalenie jej cech znamiennych (tożsamości). Rozumienie wolności gospodarczej wyznacza też stanowisko ustawodawcy, który w regulacjach ustawowych ujmuje zagadnienia przedsiębiorczości. Uwzględnia stanowisko Trybunału Konstytucyjnego na temat zasad stanowienia prawa. Istotne znaczenie dla charakterystyki wolności gospodarczej ma również prawo europejskie. Nauka publicznego prawa gospodarczego winna zestawić konstytucyjne ujęcie wolności gospodarczej z jego rozumieniem w ustawodawstwie zwykłym oraz orzecznictwie przez uwzględnienie także perspektywy europejskiej.
Współpraca niezależnych organów administracji publicznej
Authors: Wierzbowski Marek
Published: July 2015

Widoczna jest potrzeba współpracy między organami administracji publicznej, szczególnie między tzw. organami regulacyjnymi wyposażonymi w znaczny stopień niezależności od innych organów administracji. Niezależność tych organów jest mocno akcentowana w przepisach unijnych, co jednak nie wyklucza ich kooperacji z innymi organami administracji.Przepisy dotyczące szeregu organów centralnych zaliczanych do grupy „regulatorów” niejednokrotnie traktują je jako właściwie odrębne władze, a nie część jednolitego systemu administracji. Przykładem może tu być konieczność uzyskiwania odrębnych zezwoleń kilku organów na tę samą czynnośćRozstrzygnięcia organów regulacyjnych, choć nakierowane z reguły na jeden aspekt funkcjonowania podmiotów regulowanych, mają znaczenie szersze. Mogą bowiem wpływać na inne gałęzie gospodarki. Rekomendacje KNF-u dotyczące udzielania kredytów budowlanych mają istotny wpływ na funkcjonowanie sektora budowlanego, faktycznie bowiem mają wpływ na popyt na mieszkania.Tradycja administracji europejskiej zakłada silną rolę koordynatora w postaci Rady Ministrów, czy innego organu naczelnego. Nawet gdy brak wyraźnego koordynatora niezależnych organów regulacyjnych, w jakimś zakresie zastępuje go tradycja jednolitej administracji państwowej, ducha współpracy. Niestety w Polsce nie ma tej tradycji, a potrzeba pewnej wzajemnej koordynacji działań niezależnych regulatorów jest zdecydowanie widocznaTrudno sobie wyobrazić, że przepisy ograniczyłyby samodzielność organów uważanych za niezależne organy regulacyjne. Byłoby to zresztą sprzeczne z przepisami unijnymi. Można jednak stosować pewne niewładcze formy współpracy, czy wzajemnej koordynacji posunięć. Mogą też rozwijać się różne formy bilateralnej współpracy między organami – szczególnie gdy skutki rozstrzygnięć regulatora będą odczuwalne w innych działach administracji publicznej.
Ekonomia w dobie finansyzacji gospodarki
Authors: Ratajczak Marek
Published: July 2015

Pod koniec pierwszej dekady XXI w. wraz z początkiem zjawisk kryzysowych w gospodarce światowej uległa znacznemu ożywieniu dyskusja na temat kondycji nauk ekonomicznych. W artykule zaprezentowano poglądy autora na pożądane zmiany w ekonomii wynikające m.in. z uwzględnienia finansyzacji gospodarki. Ekonomia jako nauka społeczna musi ulegać ciągłym przeobrażeniom wraz ze zmianami zachodzącymi w przedmiocie jej poznania. Nawet najbardziej zaawansowane w kategoriach formalnych narzędzia poznania świata realnego nie są w stanie zapewnić możliwości w pełni skutecznego przewidywania przyszłości w sferze ekonomicznej. Nie oznacza to jednak, że można podważać naukowy status ekonomii.