bluuebunny/crossref_metadata_2025 huggingface dataset:
A Modified Technique Improved Histology Similarity to Human Intracranial Aneurysm in Rabbit Aneurysm Model
Authors: Kang W. , Connor J. , Yan X. , Neely B. , Carney E. , Ellwanger J. , Huang Y.
Published: April 2015

Persistent undigested elastic membranes and collagen in the tunic media of rabbit elastase-induced aneurysm models lowered their histology similarity to human intracranial aneurysm. Our purpose was to make good the deficiency. Ten New Zealand white rabbits were divided into three groups: six rabbit in two groups for evaluating the difference in various treatments, and four rabbits for long-term observation. We inflated and occluded the right common carotid artery (CCA) by an endovascular technique. The first group of three rabbits was only given 200u elastase in the proximal segment of right CCA; the second group was given 100u elastase and 1.5mg collagenase, then the right CCA was ligated. The first and second groups were studied by magnetic resonance angiography (MRA), sacrificed at three weeks after aneurysm creation, their histology results were obtained and compared with human aneurysm. The third group underwent the same procedure as the second group only for three months of observation with enhanced MRA. Saccular aneurysms formed in all rabbits. Degeneration of the extracellular matrix and atrophy of smooth muscular cells in tunic media were more apparent in the second group. The third group remained stable for more three months. Two modifications included inflating the right CCA with a balloon and adding collagenase incubation can promote an aneurysm model more histologically similar to human aneurysm. In addition the improved aneurysm model remains stability for a long time.
Clinical and Radiological Differences in Alzheimer's Disease with and without a History of Mild Cognitive Impairment
Authors: Modrego P.J. , Fayed N. , Olmos S.
Published: April 2015

We assessed the influence of a history of amnesic mild cognitive impairment (MCI) in patients with Alzheimer's disease (AD) at presentation from a clinical and radiological point of view. A consecutive sample of patients fulfilling the criteria of probable Alzheimer's disease according to the NINCDS-ADRDA work group not previously diagnosed nor treated underwent neuropsychological assessment including mini-mental test, Blessed dementia rating scale (BDRS), ADAS-Cog, neuropsychiatric inventory (NPI), and a daily living activities scale (DAD). Radiological evaluation consisted of magnetic resonance imaging, left hippocampal volumetry and magnetic resonance spectroscopy (MRS) of the brain. We divided the patients into two groups according to positive/negative history of MCI for a period longer than one year. The AD patients with a history of MCI were more likely to have a history of depression (OR: 5.5; 95% CI: 1.12–26) and have more depressive symptoms at presentation in the NPI than those without a history of MCI They also had a history of hypertension more frequently than the remainder. The presence/absence of ApoE4 alleles did not have influence in the clinical course. With regard to radiological findings the patients with previous MCI showed lower values of N-acetyl-aspartate (NAA) in parietal (p=0.0001) temporal (p=0.08) and occipital (p=0.00001) lobes than the other group, as well as a smaller left hippocampus although the difference was not statistically significant. A history of MCI in AD patients represents a form of the disease with slower progression from clinical and radiological viewpoints. These patients present with more depressive symptoms and a history of depression than the remainder. The lower NAA levels on MRS are compatible with a longer disease duration when AD is preceded by amnesic MCI.
Abnormal Functioning of the Thalamocortical System Underlies the Conscious Awareness of the Phantom Limb Phenomenon
Authors: Romero-Romo J.I. , Bauer C.C.C. , Pasaye E.H. , Gutiérrez R.A. , Favila R. , Barrios F.A.
Published: April 2015

Phantom limb (PL), a phenomenon experienced by most patients after amputation, has mostly served as a paradigm to study experiences that appear to be associated with neural plasticity within the CNS. However, the subjective nature of PL experiences has had no definitive means of reliable assessment other than using patients' direct reports, nor was there a way to study the neural mechanisms involved in the conscious awareness of this mental phenomenon. Here we obtained patients' indirect responses to PL experiences for an objective evaluation using functional magnetic resonance imaging (fMRI). Six control subjects and six lower limb (LL) amputees participated in a motor imagery task for both the intact and the particular phantom toes. While all subjects shared neural processing of distinctive regional cerebral activations during motor imagery of the intact toes (prefrontal (PF), supplementary motor area (SMA), primary motor cortex (M1), superior temporal gyrus (STG)), it was only during motor imagery of the amputated toes in amputees that we observed an increased blood oxygen level-dependent (BOLD) signal in the contralateral basal ganglia at the medial globus pallidus (MGP), substantia nigra (SN), and thalamus. This increased BOLD signal in the basal ganglia-thalamus-cortex pathway during imaginary movement of the phantom toes may reflect an abnormal open loop functioning of the thalamocortical system underlying the conscious awareness of the phantom phenomenon. We suggest that the reduction in afferent information contributes to and coalesces with the higher-level reorganization resulting in the subjective conscious awareness of the phantom limb.
Pilocytic Astrocytomas in Elderly Adults
Authors: Kitamura N. , Hasebe T. , Kasai R. , Kasuya S. , Nakatsuka T. , Kudo H. , Higuchi M. , Nakano K. , Hiruta N. , Kameda N. , Ogata K. , Watanabe Y. , Morita H. , Terada H.
Published: April 2015

Pilocytic astrocytomas are classified as WHO grade I gliomas that occur predominantly in children and young adults. Reports of the tumors in elderly adults are extremely rare. We describe two cases of pilocytic astrocytoma in elderly adults, a 68-year-old man and a 71-year-old woman. Brain computed tomography (CT) and magnetic resonance imaging (MRI) revealed well-circumscribed lesions associated with contrast enhancement and minimal surrounding edema. Pathological studies revealed findings consistent with pilocytic astrocytomas. Although these tumors are rarely found in elderly adults, pilocytic astrocytomas should be considered in the differential diagnosis if the radiographic features of the tumors are characteristic of pilocytic astrocytomas.
Endovascular Treatment for Cerebral Aneurysms Using Stents
Authors: Zhang J. , Lv M. , Lv X. , Jiang C. , Li Y. , Wu Z.
Published: April 2015

Endovascular stent placement combined with coil embolization is an established procedure for the treatment of intracranial aneurysms. We describe lesion outcome using stents for the treatment of intracranial aneurysms. Sixty-nine patients (30 females and 39 males; age range 12–78 years) treated with stent placement at Beijing Tiantan Hospital over a six-year period. Seventy-six cerebral aneurysms were encountered and 74 lesions were treated with 79 stents. Outcome was evaluated using the Glasgow Outcome Scale (GOS) score during a mean follow-up period of 32 months. Of the 74 stented aneurysms, 34 (45.9%) were located in the anterior circulation and 40 (54.1%) in the posterior circulation. Forty-eight (64.9%) aneurysms were small and 26 (35.1%) were large or giant. In 67 (90.5%) aneurysms embolization was completed by packing the aneurysm sac with platinum coils. In five small fusiform and four saccular aneurysms, the stent was used alone. Six procedure-related complications were observed and a cause of death in 7.2% of the patients. Follow-up angiography obtained at three months to one year in 68 (91.9%) aneurysms demonstrated complete occlusion in 43 aneurysms with a progressive thrombosis rate of 19.4% (six out of 31 aneurysms). Aneurysm recurrence occurred in four (5.8%) patients, three were treated with coil embolization and one with placement of another stent. Overall long-term outcome was good (GOS Score 4 or 5) in 92.8%, and fatal (GOS Score 1) in 7.2% of the patients. Intracranial stents can be a useful addition to coil embolization for complex broad-based aneurysms. Favorable overall long-term outcome can be achieved in 92.8% of patients when using endovascular stent placement techniques.
Treatment of a Fusiform Vertebral Aneurysm with Double Stent Placement
Authors: Liu L. , Jiang C. , Li Y. , He H. , Wu Z.
Published: April 2015

A 34-year-old man admitted to another hospital presented with sudden onset of headache. The CT scan was unremarkable, but magnetic resonance angiography revealed a fusiform aneurysm in the left vertebral artery. Six days later, the patient was sent to our institution for further diagnosis and treatment. Cerebral angiography confirmed a fusiform aneurysm located in the right vertebral artery. At first, we placed a neuroform-3 stent and could see contrast medium stasis in the aneurysm, so we did not fill coils into the aneurysm. Four months later, the patient was admitted for rechecking. DSA showed the aneurysm remained and we placed a LEO stent in the lumen of the Neuroform stent. A control DSA eight months later showed the aneurysm had almost healed. Overlapping stents may induce spontaneous thrombosis of vertebral artery aneurysms and facilitate parent artery reconstruction through flow remodeling and stent endothelialization. This technique may be an option in treating dissecting or fusiform intracranial aneurysms that are not amenable to open surgical treatment or endovascular coil embolization.
DWI Reversibility after Intra-Arterial Thrombolysis
Authors: Tortora F. , Cirillo M. , Ferrara M. , Manto A. , Briganti F. , Cirillo S.
Published: April 2015

We report our case and review the literature on reversal DWI lesions, ADC thresholds and correlation between DWI lesion and outcome measured with clinical scales. A 30-years-old woman was admitted to our hospital 18 hours after stroke onset. Considering the absence of alterations on CT and the worsening of symptomatology, the patient underwent MRI, which showed a slightly hyperintense signal in FLAIR images in the left portion of the pons and midbrain and a more evident bilateral DWI hyperintensity of the pons. The patient was treated with mechanical and pharmacological intra-arterial thrombolysis. The patient showed a rapid improvement of symptoms. Two weeks after the treatment her clinical conditions were characterized by a residual right hemiparesis and complete recovery of right motility, respiratory and swallowing difficulties. MR examination demonstrated a slight signal alteration of the pons left hemiportion and a disappearance of the mesencephalic signal alteration and of the right portion of the pons. DWI lesions represent irreversibly damaged tissue but new evidence suggests that DWI lesions may be reversible, especially with reperfusion, by now well demonstrated in animal models. Therefore acute DWI lesions probably contain not only irreversibly injured tissue but also parts of the penumbra. The debate on the capability of ADC maps to discriminate irreversibly from reversibly damaged tissue is a matter of controversy. ADC values in human stoke are not an independent indicator of tissue viability. The use of thresholds may improve reproducibility but not validity.
Unilateral Thalamic Infarction in Vein of Galen and Straight Sinus Thrombosis
Authors: Desai P.K.
Published: April 2015

Deep cerebral venous thrombosis is an uncommon event. It usually involves the halami and adjacent areas on both sides. Unilateral thalamic infarction is extremely rare subsequent to deep cerebral venous thrombosis. Imaging findings of a female in the postpartum period with unilateral thalamic infarction and basal ganglia edema are presented.
Quantitative Evaluation of the Penumbra and Ischemic Core in Acute Cerebral Infarction Using Whole-Brain CT Perfusion
Authors: Murayama K. , Katada K. , Toyama H. , Hayakawa M.
Published: April 2015

The objectives of the study were to quantitatively assess whole-brain CT Perfusion (CTP) data using an automatic region of interest (ROI) analysis program in order to distinguish between the degree of ischemia in the ischemic core and that in the penumbra and to assess the relationship between expansion of the area of infarction. The subjects were 20 patients with acute cerebral infarction. Whole-brain CTP was performed for all subjects using a 320-row area detector CT scanner. The penumbra* is defined as the region in which the CBV value is 2 mL/100 g or more and the ischemic core* is defined as the region in which the CBV value is less than 2 mL/100 g. The quantitative values of CTP parameters were automatically measured using the automatic ROIs analysis program. The Mann-Whitney U test was applied to differentiate between the ischemic core* and the penumbra*. The reduction in perfusion pressure in the penumbra* was smaller in the group with expansion of the area of infarction than in the group without expansion of the area of infarction. The difference in the median values between the penumbra* and the ischemic core* was larger in the group with expansion of the area of infarction than the group without expansion of the area of infarction. It is considered that the quantitative analysis method using whole-brain CTP may be useful for more accurately distinguishing between the ischemic core and the penumbra and for evaluating the risk of expansion of the ischemic core into the penumbra.
Challenges for Non-Invasive Brain Perfusion Quantification Using Arterial Spin Labeling
Authors: Sousa I. , Santos N. , Sanches J. , Vilela P. , Figueiredo P.
Published: April 2015

Arterial Spin Labeling (ASL) sequences for perfusion Magnetic Resonance Imaging (MRI) have recently become available to be used in the clinical practice, offering a completely noninvasive technique for the quantitative evaluation of brain perfusion. Despite its great potential, ASL perfusion imaging still presents important methodological challenges before its incorporation in routine protocols. Specifically, in some pathological conditions in which the cerebrovascular dynamics is altered, the standard application of ASL may lead to measurement errors. In these cases, it would be possible to estimate perfusion, as well as arterial transit times, by collecting images at multiple time points and then fitting a mathematical model to the data. This approach can be optimized by selecting a set of optimal imaging time points and incorporating knowledge about the physiological distributions of the parameters into the model estimation procedures. In this study, we address the challenges that arise in the measurement of brain perfusion using PASL, due to variations in the arterial transit times, by estimating the errors produced using different types of acquisitions and proposing methods for minimizing such errors. We show by simulation that multiple inversion time ASL acquisitions are expected to reduce measurement errors relative to standard approaches. In data collected from a group of subjects, we further observed reduced inter-subject variability in perfusion measurements when using a multiple versus single inversion time acquisitions. Both measurement errors and variability were further reduced if optimized acquisition and analysis techniques were employed.
Susceptibility Weighted Imaging and Cerebrovascular Disorders
Authors: Tsai Fong Y , Kao Hung-Wen , Tsui Yu-Kun , Hasso A.N. , Greensite Fred
Published: April 2015

To investigate the correlation between the SWI findings and prognosis of the cerebrovascular disorders. From July 2008 to July 2010, 299 ischemic stroke patients were found in our hospital. The gender ratio is as male and female being 157 to 142. The mean age of all patients is 65.4, mean female age is 69.1, and mean male age is 62.6. There were 86 patients who had satisfactory pre-and post-treatment of CT, MRI with SWI. 23 of these 86 patients had catheter cerebral angiography. 50 of these 86 patients had MR angiogram or CT angiogram. 13 of these 86 patients did not have angiogram. We have also collected 7 severe cardiac arrested and cessation of cerebral circulation and 2 patients with chronic venous hypertension. Among the 86 patients, 23 patients who had negative with deoxygenated vessel on SWI were with small infarction on DWI Thirty-one patients had negative on initial CT head scan. CT finding did not accord with presence of hypointense vessel on SWI. Sixty-three patients had varied degree of abnormal hypointense vessels on SWI as deoxygenated vessels. The initial small foci on DWI may result with a larger infarction if there were with prominent hypointense vessels.
Correlative ROI Calculation of MCAs: Another Promising Primary Sign of Acute Infarction?
Authors: Panagi G. , Fondara S. , Zorzou M.P. , Sgora E. , Kastania M. , Koulai L. , Chalkias S. , Dounias G.
Published: April 2015

The purpose of this project was to calculate the ROI of the middle cerebral artery (MCA) in patients with acute stroke to establish if this measurement could be used as another primary sign of infarction even if other established primary signs of infarction are absent. CT brain scans of 465 patients, who presented in the emergency room in the first six hours after the onset of symptoms, were studied retrospectively. Two polygonal ROIs were drawn on the M1 segments of both middle cerebral arteries and three parameters were calculated automatically: HU density, volume and surface of the corresponding artery segment. The age and gender of each patient were also recorded, as well as the CT findings (including the hyperdense appearance of MCA and the insular ribbon sign) and the neurological findings. The range of calculated ROIs was between 9 HU and 134 HU. A statistically significant difference was reported in ROI measurement between the right and left MCA in patients with left (or right) hemiparesis respectively. A significant difference was also reported between the ROIs of the right and left MCA in patients with acute ischemic stroke in the region of the brain supplied by the left (or right) MCA respectively. ROI measurement of MCA is easy to apply and interpret during the CT scan and might serve as an additional primary sign of infarction.
Use of Cervical Spinal Cord Stimulation in Treatment and Prevention of Arterial Vasospasm after Aneurysmal Subarachnoid Hemorrhage
Authors: Slavin K.V. , Vannemreddy P.S.S.V. , Goellner E. , Alaraj A.M. , Aydin S. , Eboli P. , Mlinarevich N. , Watson K.S. , Walters L.E. , Amin-Hanjani S. , Deveshwar R. , Aletich V. , Charbel F.T.
Published: April 2015

Based on past laboratory and anecdotal clinical experience, we hypothesized that prolonged cervical spinal cord stimulation (SCS) in the acute settings of aneurysmal subarachnoid hemorrhage (aSAH) would be both safe and feasible, and that 2-week stimulation will reduce incidence of cerebral arterial vasospasm. The goal of our clinical study was to establish feasibility and safety of cervical SCS in a small group of selected aSAH patients. Single-arm non-randomized prospective study of cSCS in aSAH patients involved percutaneous implantation of 8-contact electrode in 12 consecutive aSAH patients that satisfied strict inclusion criteria. The electrode insertion was performed immediately upon surgical or endovascular securing of the ruptured aneurysm while the patient was still under general anesthesia. Patients were stimulated for 14 consecutive days or until discharge. There were no complications related to the electrode insertion or to SCS during the study and no long-term side effects of SCS during 1-year follow-up. There was 1 unrelated death and two electrode pullouts. This article summarizes technical details of SCS electrode insertion and the stimulation parameters used in the research study. Our study of SCS for prevention of vasospasm after aSAH conclusively shows both safety and feasibility of this promising treatment approach. Despite high level of acuity in aSAH patients, impaired level of consciousness, frequent patient repositioning, need in multiple tests and variety of monitors, SCS electrodes may be safely implanted and maintained for the two-week period. Long-term follow up shows no adverse effects of cervical SCS in this patient category.
Diffusion Abnormality of Corpus Callosum in Alzheimer's Disease
Authors: FindikoğLu A. , Ercan K. , Günbey H.
Published: April 2015

This study investigated diffusion abnormalities in the parts of corpus callosum (CC) of patients with Alzheimer's disease (AD) using diffusion tensor magnetic resonance imaging (DT-MRI). Twenty-one patients with AD and 20 healthy volunteers participated in the study. MRI was performed with a 1.5 T system. Conventional MR images and diffusion tensor images were obtained for all participants. We divided the CC into three parts as rostrum, body and splenium. The apparent diffusion coefficiency (ADC) and fractional anisotropy (FA) were measured in all parts. FA values for the CC were lower in AD patients than the values of controls. In AD patients the lowest values were found in the rostrum of the CC and CC body FA values were also lower than the splenium, but the difference did not reach statistical significance. DT-MRI is a promising technique to investigate microstructural changes in white matter regions in AD. Early detection of the disease has been increasingly studied in AD. Further studies with larger populations are needed to confirm the role of diffusion tensor imaging in the evaluation of memory impairment.
Neuroimaging in Seizure Patients Associated with Nonketotic Hyperglycemia
Authors: Chen C.C-C. , Chai J-W. , Wu C-H. , Chen W-S. , Hung H-C. , Lee S-K.
Published: April 2015

Nonketotic hyperglycemia (NKH) is a clinical syndrome consisting of hyperglycemia, hyperosmolality and intracellular dehydration but not ketoacidosis. This prospective study evaluated the clinical and magnetic resonance imaging abnormalities in six patients with NKH complicated with simple or complex partial seizures. Subcortical T2 hypointensity rather than hyperintensity together with contrast enhancement was a characteristic feature of seizures associated with NKH. Restricted diffusion on DWI and decreased NAA and/or Choline on MRS studies were also noted.
Extrapontine Myelinolysis and Cortical Laminar Necrosis Caused by Severe Hypernatremia following Peritoneal Lavage for Ruptured Hydatid Cyst of the Liver
Authors: Szólics M. , Ljubisavljevic M. , Samir HA , Megahed M. , Chaudhry F.
Published: April 2015

Extrapontine myelinolysis (EPM) and cortical laminar necrosis (CLN) have rarely been reported in association with severe hypernatremia. We describe a patient with EPM associated with CLN following severe hypernatremia due to hypertonic peritoneal lavage after a ruptured hydatid cyst of the liver. Clinical and neuroimaging findings in acute stage and serial brain MRI at two and five month follow-up are discussed in detail.
Fibromuscular Dysplasia of the Middle Cerebral Artery in an Adolescent Male
Authors: Rosa S. , Derakhshani S. , Chawda S.
Published: April 2015

To illustrate the imaging features of fibromuscular dysplasia (FMD) in this rare presumptive case of FMD in a sixteen year old male with intracranial features only and highlight it as an important cause of stroke in the young. FMD is a non-atheroscelerotic, non-inflammatory vasculopathic arterial disease affecting large and medium size vessels of unknown aetiology. It is a rare cause of paediatric stroke and strokes in young adults. This is a pictorial presentation of an unusual presumptive case of fibromuscular dysplasia (FMD) affecting the middle cerebral artery in a sixteen year old male with classic Digital Subtraction Angiography (DSA) findings. The focal neurological findings and pattern seen on sequential brain scans clearly associates the presence of this vascular lesion to cerebral infarction. Classic imaging findings of the epidemiology, pathology and radiological appearance of FMD are discussed. Emphasis is placed on the patient's imaging presentations including DSA. FMD is a vascular dysplasia that typical affects the renal vasculature and commonly the extracranial internal carotid artery. When a young adult or child presents with stroke FMD should be considered and is more likely to have intracranial features.
Global Functional Disconnections in Post-anoxic Coma Patient
Authors: Achard S. , Kremer S. , Schenck M. , Renard F. , Ong-Nicolas C. , Namer J. I. , Mutschler V. , Schneider F. , Delon-Martin C.
Published: April 2015

Disorders of consciousness have been related to different disconnection patterns as assessed by neuroimaging tools such as PET or fMRI. In this report, we use resting-state functional MRI acquisition and a functional connectivity analysis by graph of brain networks, to investigate the global residual connection pattern in a patient with consciousness disorders following post-anoxic injury. We then compare this pattern with those of a group of twenty controls. We observed that the patient's graph presents multiple disconnections in primary areas and in high-order associative areas. This pattern is consistent with a vegetative state, as reported by other groups. Further, the informations conveyed by this approach are consistent with those provided by PET, fMRI and EP. This new approach presents a very strong potential for diagnosis for consciousness disorder patients since it is applicable very early after the insult.
Secondary Corpus Callosum Abnormalities Associated with Antiepileptic Drugs in Temporal Lobe Epilepsy
Authors: Günbey H.P. , Ercan K. , FindikoğLu A.S. , Bilir E. , Karaoglanoglu M. , Komurcu F. , Alhan A.
Published: April 2015

Epilepsy is more than a grey-matter disorder affecting large white matter connections of the brain with seizure generation and propagation. The mechanism for such changes remains unclear. The purpose of this study was to investigate the microstructural changes in the corpus callosum in temporal lobe epilepsy (TLE) patients and whether these abnormalities are related to antiepileptic drug (AED) therapy. Ten TLE patients receiving AED therapy, ten TLE patients with no therapy and ten controls were included in the study. The regions of interest in the corpus callosum were outlined to each Witelson region (WR). Fractional anisotrophy (FA), apparent diffusion coefficient (ADC), three main diffusivity values (λ1, λ2, λ3) and tractography were acquired from each WR. DTI indices of these tracts and each WR were compared between the three subject groups and correlates examined with clinical variables that included duration of epilepsy, gender, AED type and AED therapy exposure. In TLE subjects with receiving AED therapy significantly (p<0.05) decreased FA and increased ADC values of corpus callosum were obtained when compared to the other groups. There was no significant relationship between AED type and DTI indices. Analysis of eigen values in the splenium of corpus callosum (WR7) showed λ1 values were significantly decreased in relation to AED medication duration (p<0.05). FA values of rostrum and corpus showed a reduction with duration of epilepsy. TLE is associated with abnormal integrity of corpus callosum white matter tracts. AED therapy may cause additional damage on secondary degeneration and medication time effects especially on the splenium of corpus callosum.
Intracranial Masses with Perilesional Edema: Differential Diagnosis with Perfusion CT
Authors: Gadda D. , Simonelli P. , Villa G. , Scardigli V. , Petacchi D. , Pandolfo C. , Moretti M. , Chiti S. , Giordano G.P.
Published: April 2015

Perilesional edema (PE) is commonly observed in association with an intracranial mass. PE is thought to be determined by vasogenic effects in the cerebral parenchyma surrounding the mass due to the loss or absence of the blood-brain barrier (BBB) inside the lesion. Alterations in capillary permeability induce extrusion of fluids into the extravascular space around the mass. On Computed Tomography (CT) PE corresponds to an area of low density for the increased water content, outside the margins of the lesion. It is difficult to differentiate PE from areas of parenchymal compressive ischemia and sometimes the two events could be associated. A solitary mass with PE is more commonly discovered on a non-enhanced computed tomography (NECT) study performed for the onset of stable or rapidly progressive neurological symptoms. In such cases, a supplementary CT scan with contrast (CECT) is generally indicated to complete the baseline imaging before MRI. Contrast enhancement is generally present in a mass with PE and it is not specific for differential diagnosis. Perfusion computed tomography (PCT) requires a few minutes in addition to the time needed for CECT. PCT may give information on regional microvascular density, permeability and blood flow, thus it may play a role when tumoral neo-angiogenesis or non-neoplastic altered haemodynamics are suspected. We therefore investigated the utility of PCT in the differential diagnosis of the intracranial solitary masses with PE.
Revisiting the CNS Tuberculosis with Emphasis on Giant Tuberculomas and Introducing the “Outer Rim Excrescence Sign”
Authors: Kumar D. , Sheoran R.K. , Bansal S.K. , Arora O.P.
Published: April 2015

Central nervous system tuberculosis is a leading cause of morbidity and mortality in developing countries with Mycobacterium tuberculosis as the main etiological agent. Classical imaging findings pose no problem for diagnosis of CNS tuberculosis. Cases of giant or solitary ring enhancing lesions are increasing which mimic other infectious and noninfectious pathologies. This is a retrospective study of 40 patients (28 male and 12 female) of either surgically or clinically proven CNS tuberculosis. Solitary tuberculomas (ring or solid enhancing) were seen in 19 patients. Four patients showed presence of two to three lesions and the lesion more than one centimeter size was categorized as ‘giant tuberculoma’. Multiple lesions with other associated findings were noted in 21 patients. Total 33 patients showed solitary or multiple ring enhancing lesions. Seven patients showed solid enhancing lesions (giant tuberculoma). The “Outer rim excrescence sign” was noted in a total of 16 patients. Both brain and spinal tuberculosis was noted in six patients. Seven patients presented with meningitis and hydrocephalous which is considered as the most common manifestation in the literature. Spinal leptomeningeal involvement was seen in five patients, whereas intramedullary cord tuberculomas were noted in four patients. Profound T2W hypointensity is a reliable predictor for giant tuberculomas with intense contrast enhancement, especially in deep locations. ‘Outer rim excrescence’ sign may contribute in cases of ring and solid enhancing lesions, however it requires further comprehensive study with MT Imaging and MR Spectroscopy to be recorded as a differentiating feature.
CT and MRI Correlations in Patients with Suspected Cholesteatoma after Surgery
Authors: Cabellos J.A. Blanco , Vélez S. Ossaba , Cáceres I. Albade , Lluch E. Soler , Monje J. Galobardes
Published: April 2015

The study of postoperative ear cavities in patients who underwent surgery for cholesteatoma is a difficult challenge for radiologists. In our study we make a correlation between CT and MRI findings, useful tools in patients with suspected residual or recurrent cholesteatoma. The use of different MRI sequences especially DWI can help radiologists to discriminate between cholesteatoma and other different processes.
MDCT Assessment of the Cochlear-Carotid Interval
Authors: Gunbey H.P. , Aydin H. , Cetin H. , Gunbey E. , Karaoglanoglu M. , Cay N. , Alhan A.
Published: April 2015

The close anatomic course between the cochlea and the carotid artery presents a possible surgical risk during increasingly popular cohlear implant surgery. The purpose of this study was to determine the normal range of the this region termed “cohlear- carotid interval” (CCI) by 64-slice multi-detector computed tomography (MDCT) in the population. The study investigated 1105 patients who had undergone temporal MDCT. The CCI measured by two observers from 0.5 mm thick coronal images with confirmation on axial and sagittal planes. Among 1105 patients and 2210 temporal sides CCI measured 0.0 mm unilaterally in eight (0.7%) and bilaterally in two patients (0.1%) with a score of ten in the total population (0.9%). Total scores ranged from 0.0 to 6 mm for right CCI and 0.0 to 5.9 mm for left CCI. The CCI showed no significant relationship with sex (P=.096) and there were no significant differences between readers (P=.457) and sides (P=.879). A positive correlation (r=0.741) was found between right and left CCI. The present study demonstrated that the CCI varies considerably between 0.0 mm and 6 mm independently of sex in the population. Understanding the importance of CCI and preoperative knowledge of thin or absent bone allows the radiologist to play a crucial role in alerting the surgeon to prevent penetration of the carotid canal during cochlear implant surgery.
Magnetic Resonance Imaging of the Oculomotor Nerve
Authors: Sethi K.S. , Das C.J.
Published: April 2015

Oculomotor/cranial nerve III palsy is caused by numerous etiologies involving the brainstem, subarachnoid space, cavernous sinus or superior orbital fissure or orbit. Magnetic resonance imaging (MRI) is the most suitable neuro-imaging technique in patients with this presentation to rule out a mass, aneurysm or ischemic vasculopathy. A pictorial review of various pathologies affecting the oculomotor nerve is presented along with their MRI morphology.
The Encephalopathic Child
Authors: Abeyakoon O. , Batty R. , Mordekar S. , Raghavan A. , Sinha S. , Griffiths P.D. , Connolly D.J.A.
Published: April 2015

Encephalopathy is a common paediatric emergency associated with a high risk of morbidity, mortality and long term neurodevelopmental delay in survivors. Prompt diagnosis of the cause of encephalopathy enables the paediatrician to deliver specific medical or surgical treatment that will facilitate a better short and long term outcome. Diagnostic imaging plays a pivotal role in diagnosis. Encephalopathy has many causes. The differential diagnosis includes non accidental injury, trauma, metabolic syndromes, meningo-encephalitis, toxins, hypoxia, demyelination, stroke, haemorrhage and tumours. We describe an approach that helps us formulate an imaging strategy using US, CT and MRI that facilitates patient care.
MRI Findings of Dorsalgia
Authors: Inugami A. , Okane K.
Published: April 2015

We reviewed the thoracic vertebra MRI of patients whose chief complaint was dorsalgia (or + lower back dorsalgia). Thoracic vertebra MRI of 103 patients had dorsalgia as the chief complaint mainly or sometimes in 134 (man 61, woman 73) and had led them to consult an orthopaedic specialist. A difference was seen in the cavity diameter under the posterior arachnoid in 103 and 31 which led to MRI scan of the thoracic vertebra. The cavity diameter was equal to or more than 0.55 posterior space, equal to or less than 0.43 abdominal side space. We reviewed the thoracic vertebra MRI of the patients whose the chief complaint was dorsalgia (or lower back dorsalgia). On the thoracic vertebra sagittal T2w MR scans we obtained eccentricities from the center to the thoracic ventral aspect and to the dorsal aspect at the widest diameter of the spinal canal. The eccentricities were calculated as ratios of the diameter of the spinal canal at the maximal occipitofrontal diameter to the dorsal subarachnoid space diameter, and to the ventral subarachnoid space diameter. Spinal cord imaging was done by exclusion to the abdominal side because the cavity diameter under the posterior arachnoid was wide. The ventral root was towed and the dorsal root was assumed to be bent.
Which Factors Increase Procedural Thromboembolic Events in Patients with Unruptured Paraclinoid Internal Carotid Artery Aneurysm Treated by Coil Embolization?
Authors: Nagahata M. , Kondo R. , Saito S. , Takemura A. , Hatayama T
Published: April 2015

We analyzed the factors which increase the frequency of procedural thromboembolic events during coil embolization of unruptured paraclinoid internal carotid artery aneurysms. Neurologically symptomatic complications did not occur in our series. Silent hyperintense lesions on postoperative DWI were frequently detected after the coiling procedure in which we needed to withdraw the unreleased coil. Patient's age, sex, aneurysm diameter, packing density, use of balloon-assisted technique, and exchanging maneuver of microcatheter during the procedure did not increase the frequency of silent thromboembolic events.
Vertebral Artery Orifice Stenosis: A Report of 43 Cases from Northwest Iran Treated with Angioplasty and Stenting
Authors: Mohammadian R. , Najaran A. , Sohrabi B. , Mansourizadeh R. , Mohammadian F. , Nasiri B. , Farhoudi M.
Published: April 2015

More than one quarter of all transient ischemic attacks (TIA's) and ischemic strokes involve tissue supplied by the vertebrobasilar (VB) circulation. Vertebral artery stenotic lesion, particularly at the origin of the vertebral artery, is not uncommon but it is a less studied area. Here we present our endovascular treatment experience in a group of patients with vertebral artery orifice stenosis. We enrolled a group of patients with vertebral artery orifice stenosis who presented with confirmed posterior circulation stroke. Vertebrobasilar insufficiency syndrome was confirmed by imaging studies and clinical findings. Vertebral artery stenosis diagnosed by CT or MR Angiography and confirmed by Conventional and digital subtraction angiography (DSA). Angiography was performed by using of femoral or radial artery approach. From October 2008 to January 2010, forty-three consecutive patients (69.8% men) underwent stent placement for symptomatic vertebral artery orifice stenosis. Mean degree of stenosis was 70.45 +/− 7.455 percent and mean age was 71.65 +/− 7.743 years. In the 22 patients (22/43, 51.16%) stenosis were in left side. In the thirty patients (30/43, 69.6%) there was evidence of atherosclerotic disease in the internal carotid artery and in the 23% contra lateral vertebral artery was involved. There were five different cases with left renal artery stenosis especially in the men with left vertebral artery stenosis. Initial technical success rate was 100%. No cerebrovascular complications or embolic events occurred. Six months control angiography follow-up revealed one patient with stent occlusion and moderate (40%) restenosis in the another patient. According to our finding angioplasty and stenting for vertebral artery orifice stenosis is safe and effective. Patients with vertebral artery orifice disease frequently have coexistent atherosclerotic stenosis in the other major extracranial arteries including carotid and renal arteries.
Detached Coil Migration that Assisted Stent Migration, during Stent Assisted Coiling of a Recurrent Aneurysm
Authors: Derakhshani S. , Rosa S. , Chawda S.
Published: April 2015

This is a pictorial case report of previously unreported intra-procedural complication of an intra-procedural migrated stent-coil complex. It shows fluoroscopic detail of the migration of a stent with the help of a migrated coil with subsequent retrieval of coil and deployment of a second stent proximally. It also briefly covers postulated mechanisms for this in the discussion. In our clinical practice we experienced an unusual case during stent assisted coiling of a right Posterior Communicating Artery Aneurysm (PCOM) where a coil migrated through a deployed stent into the parent artery and become ensnared into a distal stent strut. This caused stent migration distally. Studies have shown that stent assisted coiling of cerebral aneurysms is an effective treatment that lowers the risk of recurrence. There are several complications associated with both coiling and stent deployment. Multiple cases of individual coil migration and stent misplacement have been described in the literature, such as coil protrusion through a stent with open cell designs and a single case of delayed coil migration through a deployed stent. Various aetiologies are described for these, which we cover, and we postulate on the factors relevant to our case and suggest the biggest contributing factor was an open side stent design. We believe this is a rare documented acute case of a migrated coil that has assisted stent migration. We suggest caution particularly when small coils need to be deployed alongside open cell and side design stents.
High Resolution CT Angiography in Detection of an Aneurysm of the Vein of Galen as a Source of Intracranial Haemorrhage in a Newborn
Authors: Salerno S. , Di Giovanna E. , Morra A. , Bonsignore G. , Piro E.
Published: April 2015

Cerebral haemorrhage is a rare condition in infants and carries a known poor prognosis. Common causes of spontaneous haemorrhage include various vascular venous lesions due to incomplete hydrovenous maturation, among them Galen vein aneurysm may be a very rare cause of cerebral haemorrhage. This report emphasizes the role of multidector CT with high resolution CT angiography in a newborn with cerebral hemorrhage caused by Galen vein aneurysm rupture. MDCT with high resolution CT angiography helps to differentiate the cause of haemorrhage, and to address the appropriate treatment.
MR Study of Child Discloses Bilateral Papilledema and Optic Nerve Swelling. CSF Examination Positive for HSV-1 DNA. Could This Be a Rare Primary Manifestation of Herpes Infection?
Authors: D'Amore A. , Pero G.
Published: April 2015

We describe a rare case of bilateral papilledema and optic nerve swelling in a young patient with bilateral loss of visual acuity five days after onset of muscle contraction and pain involving the neck and right upper and lower limbs. This rare finding may be a possible first manifestation in a human patient of viral disease linked to HSV-1. MR study confirmed edema of the optic disc and evidence of optic nerve swelling. PCR for HSV-1 DNA was positive in the cerebrospinal fluid.
Decision-Making in the Scheduling of Endovascular Treatment after Brain Arteriovenous Malformation Haemorrhage: A Retrospective Single Centre Study
Authors: Downer J.J. , Cellerini M. , Corkill R.A. , Lalloo S. , Küker W. , Byrne J.V.
Published: April 2015

The appropriate timing for endovascular intervention after brain arteriovenous malformation (bAVM) rupture is not known. This paper aims to determine factors that lead to early endovascular intervention and to investigate whether early intervention has the same complication rate as late intervention in a single centre. All patients who underwent endovascular treatment for a ruptured bAVM at our institution in the period January 2007 and July 2010 were included in this retrospective observational study. Of 50 patients, 33 had early endovascular intervention, defined as within 30 days of haemorrhage and the remaining 17 patients had endovascular treatment at day 30 or beyond. A greater proportion of patients treated within the first 30 days were in neurointensive care preoperatively (51.5% vs. 23.5%, p=0.07). A ‘high-risk’ angioarchitectural feature was identified in more patients who had acute intervention (78.8% vs. 11.8%, p<0.0001) and targeted embolization was also more frequent in this group (48.5% vs. 5.9%, p=0.004). Nidal aneurysms, venous varices and impaired venous outflow (venous stenosis) were the principal ‘high risk’ features. Clinically apparent complications occurred in 10.8% of procedures with permanent neurological deficit in 3.6%. There was no directly procedure-related mortality. There was no statistically significant difference in the complication rate of early procedures compared with delayed interventions (12.5% vs. 7.4%, p=0.71). Greater initial injury severity and the presence of high-risk lesion characteristics are the factors that lead to early endovascular intervention. Early intervention is associated with a higher complication rate, but this difference is not statistically significant.
CT-Guided Posterior Lumbar Interbody Fusion and Distraction
Authors: Manfré L.
Published: April 2015

We performed CT-guided posterior interbody fusion (PIF) with pedicle screw fixation and distraction to treat degenerative lumbar L4-L5 spondylolisthesis with severe left sciatica. The patient was suffering from L4 nerve root compression related to neural foramina stenosis. The dedicated tools to perform a CT-guided percutaneous PIF technique are described. The procedure was easy to apply with a total surgical time of 90 minutes. The neural foramina were investigated by CT scan reconstruction on sagittal plane demonstrating marked widening after PIF application. The left leg pain completely disappeared in two weeks and the patient remained painless at the three month follow-up control. To our knowledge, there are no other papers on CT-guided PIF procedure in the literature.
MRI Localization of Mildly Symptomatic Ectopic Retropharyngeal Parathyroid Adenoma: The Impact on Surgical Approach
Authors: El Beltagi A.H. , Alsabah B. , Al-Shaiyer D. , El-Shahat H.
Published: April 2015

Ectopic parathyroid glands tend to be located in positions defined by their embryologic path during fetal development. We describe such a case of primary hyperparathyroidism due to ectopic retropharyngeal parathyroid adenoma (PTA) in a teenage girl with mild symptomatology. The initial workup with scintigraphy showed suspicious uptake above the level of thyroid gland, ultrasound, and computed tomography failed to localize an adenoma. Magnetic resonance imaging precisely localized an ectopic retropharyngeal PTA, which led to successful surgical removal.
Fabry Disease Presenting with Multiple Hemorrhagic Cerebral Infarction
Authors: Ooka M. , Iizuka Y. , Nomoto N. , Fujioka T. , Shimizu N. , Sekine T. , Kohda E.
Published: April 2015

We describe a 57-year-old woman, a heterozygote for Fabry disease who had multiple hemorrhagic cerebral infarctions. Her clinical course and radiological findings suggested cardiogenic cerebral embolus, but distinction from multiple cerebral infarction associated with Fabry disease seemed necessary. Our present case is reported with reference to the literature to introduce various types of stroke, which can develop in patients with Fabry disease.
Early Appearance of Diffusion-Weighted Hyperintensities in Aphasic Status Epilepticus
Authors: Maalouf N. , Keyrouz S.G.
Published: April 2015

Partial status epilepticus rarely manifests mainly with global aphasia. It usually results in diffusion-weighted imaging (DWI) abnormalities after prolonged seizures. We discuss the magnetic resonance imaging (MRI) findings in a patient with aphasic status epilepticus. MRI showed diffusion restriction four hours after onset of symptoms. We summarize previously reported brain imaging findings in status epilepticus and discuss the purported mechanism behind these changes. Findings in our patient, similar to few others described in the literature, suggest that cortical DWI hyperintensities can occur shortly following aphasic status epilepticus.