bluuebunny/crossref_metadata_2025 huggingface dataset:
Identifikasi Jamur Pada Kuku Penderita Diabetes Melitus di Griya Sehat Link Care Kecamatan Gantarang Kabupaten Bulukumba
Authors: Aulia Iin , Ridwan Asriyani , Asnidar Asnidar
Published: January 2025

Penderita Diabetes Mellitus memiliki risiko lebih tinggi mengalami infeksi jamur pada kuku karena diabetes dapat melemahkan sistem kekebalan tubuh dan mengganggu sirkulasi darah, termasuk ke area kuku. Penelitian ini bertujuan untuk mengidentifikasi ada atau tidaknya jamur pada kuku penderita Diabetes Mellitus di Griya Sehat Link Care, Kecamatan Gantarang, Kabupaten Bulukumba. Jenis penelitian ini bersifat deskriptif dengan metode kultur jamur pada media SDA dan pemeriksaan mikroskopis menggunakan KOH 10%. Berdasarkan hasil identifikasi jamur pada 20 sampel kuku penderita Diabetes Mellitus yang diperiksa di Klinik Griya Sehat pada 15-19 Juli 2024, ditemukan 16 sampel positif terinfeksi jamur pada kuku dan 4 sampel negatif tanpa identifikasi jamur. Dari hasil penelitian ini, dapat disimpulkan bahwa pada 20 sampel kuku pasien Diabetes Mellitus yang diperiksa secara makroskopis dan mikroskopis, ditemukan keberadaan jamur Non-Dermatophyte, yaitu Aspergillus sp. dan Candida albicans pada kuku pasien Diabetes Mellitus di Griya Sehat Link Care, Kecamatan Gantarang, Kabupaten Bulukumba.
Dukungan Pemerintah Daerah terhadap Pencapaian Universal Health Coverage (UHC) di Kabupaten Luwu Timur
Authors: Mutjahidah Mutjahidah , Istiqamah Nurul Fajriah
Published: January 2025

Pemerintah daerah sebagai tulang punggung program nasional mempunyai tiga peran strategis dalam mewujudkan pencapaian UHC, yaitu cakupan kepesertaan, pelayanan kesehatan dan kepatuhan iuran. Penelitian ini bertujuan untuk mengidentifikasi pengaruh dukungan pemerintah terhadap pencapaian UHC di Kabupaten Luwu Timur. Desain penelitian adalah kualitatif deskriptif dengan jumlah informan sebanyak 5 orang yang dipilih secara purposive sampling. Data diperoleh melalui wawancara mendalam meliputi cakupan kepesertaan dan pelayanan kesehatan. Analisis triangulasi data digunakan untuk mendapatkan keabsahan data. Hasil penelitian menunjukkan bahwa berdasarkan aspek cakupan kepesertaan, pemda Kab. Luwu Timur melakukan validasi data kependudukan untuk pengalokasian anggaran peserta PBI, serta melakukan sosialisasi melalui Puskesmas dan bidan desa untuk mencakup peserta. Aspek pelayanan kesehatan, pemda Kab. Luwu Timur terus melakukan peningkatan jumlah fasilitas kesehatan dan menyediakan sarana prasarana yang memadai. Disimpulkan bahwa dukungan pemda Kab. Luwu Timur berpengaruh besar terhadap pencapaian UHC di Kab. Luwu Timur dari aspek cakupan kepesertaan dan pelayanan kesehatan. Diharapkan dapat menjaga dan memelihara keberlanjutan UHC di Kab. Luwu Timur serta pemerataan pelayanan kesehatan.
Pengembangan Modul Pembelajaran Ipa Berdasarkan Studi Pemanfaatan Tumbuhan Obat Di Desa Nusa Ambu Kecamatan Wasile Selatan Kabupaten Halmahera Timur
Authors: Muhammad Waode Lindawati , Abbas Nurhasnah
Published: January 2025

Proses pembelajaran memerlukan bahan ajar yang mendukung, salah satunya adalah modul. Modul dirancang secara sistematis dengan bahasa yang mudah dipahami agar siswa dapat belajar mandiri. Observasi di SMP Negeri 7 Wasile Selatan menunjukkan bahwa pelajaran IPA masih bergantung pada buku teks dengan minimnya bahan ajar pendukung seperti modul. Penelitian ini bertujuan mengembangkan modul IPA berbasis pemanfaatan tumbuhan obat di Desa Nusa Ambu dan mengukur validitasnya. Penelitian ini menggunakan metode pengembangan R&D dengan model ADDIE, yang meliputi Analyze, Design, Development, Implementation, dan Evaluation. Namun, karena pembatasan pandemi COVID-19, penelitian hanya dilakukan hingga tahap Design dan Development. Validasi menunjukkan tingkat kelayakan modul mencapai 91,66% untuk aspek materi (sangat layak) dan 78,57% untuk aspek desain dan bahasa (layak). Hasil penelitian merekomendasikan uji coba lapangan untuk mengukur efektivitas modul.
A Post-Colonial Study in the Works of RK Narayan
Authors: Shambhavi Dr. Shambhavi
Published: January 2025

In history, we begin to see the violence of colonialism – which was not only political, social, economic, or military but epistemological and cultural too. Colonialism cannot merely be seen as a political or economic system but rather as a powerful cultural and epistemological tool that resulted in the conquest of the native population of non–European countries and, to some extent, over settler colonies which gained acquaintance and knowledge over the native population through the medium of translations, commentaries, and academic studies and later destroyed or modified native system of thinking claiming European languages as the only fit medium which can ensure development, technological advancement, equality and modernization of the human civilization as a whole. The paper attempts to throw light on Narayan’s works as a medium that explored in considerable depth the ill effects of colonialism, racism, and exploitation long before the creators of imaginative literature attempted in their works of post-colonial writings.
Pneumotórax secundário ao acesso central em veia subclávia: manejo em cirurgia geral e emergência
Authors: Lippe Marcela Maria Ferreira , Pomerening Goulart Vinicius , Moura de Oliveira Gabriele , Rocha Mendes Sasha Thallia , Pulido Casarim Fernanda Caroline , Neres Vargas Rafaella Vitória , Lima Mourão João Paulo , Costenaro dos Santos Thaís , Nogueira Rodrigues Ferreira Thiago Portilho
Published: January 2025

O pneumotórax secundário à Cateterização Venosa Central (CVC) pela veia subclávia é uma complicação relevante em ambientes cirúrgicos e de emergência, resultante da proximidade anatômica dessa veia com o ápice pulmonar. Esse risco elevado, em comparação com acessos venosos pela veia jugular interna ou femoral, destaca a necessidade de técnicas seguras de inserção. Este estudo teve como objetivo analisar estratégias de prevenção, diagnóstico e manejo do pneumotórax secundário à CVC subclávia, com foco nas condutas adotadas em cirurgia geral e emergência. Foi realizada uma revisão integrativa da literatura nas bases PubMed, SciELO, LILACS e Google Scholar, dos anos de 2001 a 2024, utilizando descritores relacionados ao tema. Os resultados apontam que o uso de ultrassonografia em tempo real reduz significativamente complicações mecânicas, enquanto a drenagem torácica continua sendo o tratamento padrão para casos graves. A aspiração com agulha surge como alternativa menos invasiva em pacientes estáveis, e a cirurgia Toracoscópica Videoassistida (VATS) é indicada para casos persistentes ou recorrentes. Conclui-se que o manejo do pneumotórax demanda uma abordagem multidisciplinar e individualizada, combinando métodos seguros de inserção e intervenções adequadas. Entretanto, são necessários mais estudos para aprimorar as estratégias de prevenção e tratamento, garantindo maior segurança e eficácia no cuidado ao paciente.
Các dấu hiệu của cấu thành tội phạm - Những vấn đề được đặt ra cho Bộ luật Hình sự Việt Nam
Authors: NGUYỄN NGỌC HÒA
Published: January 2025

The article analyses the shortcoming of the Penal Code in its prescription of the elements of crimes, including the common elements and special elements that define crimes as well as the elements that determine the penalty frames. The article also analyses the Penal Code’s inaccuracy in introducing the guidelines for the application of criminal law in the prescription of elements of crimes, including incorrect guidelines. Based on those analyses, the author provides recommendations for the improvement of the Penal Code in terms of the prescription of elements of crimes.
3D printing of cellulose-based biomaterials: A review
Authors: Huang Jincheng , Li Lei
Published: January 2025

With the development of 3D printing technologies, cellulose has been explored to realize its sophisticated geometry fabrication in this field for a variety of applications. This review focuses specifically on the latest research progress of 3D printing cellulose by discussing the characteristics of cellulose materials, different 3D printing technologies, and their optimal performance for applications in various fields like biomedicine, food packaging, and tissue engineering. The challenges of preparing 3D printing "ink" of cellulose using dissolved cellulose or nanocellulose are introduced. Finally, the corresponding applications of cellulose using 3D printing are classified and the strategies to optimize production performance are provided.
Análisis de las percepciones del nivel de conocimiento sobre las TAC en docentes de bachillerato de la zona norte del Ecuador
Authors: Arias Benalcázar Diana Verónica , Arias Coronado Johselyn Karina , Cabascango Tuquerres Angela Cristina , Campos Ortiz Juan Marcelo , Lastra Garcia Elisa Marisol , Muñoz Herrera Edgar José
Published: January 2025

Este estudio analiza las percepciones de 150 docentes de bachillerato en la zona norte de Ecuador sobre el conocimiento y uso de las Tecnologías del Aprendizaje y del Conocimiento (TAC), los resultados destacan una percepción positiva sobre el impacto de las TAC en el aprendizaje, aunque persisten barreras relacionadas con el acceso a recursos y la capacitación docente; el análisis de chi-cuadrado mostró asociaciones significativas entre las percepciones y variables sociodemográficas, lo que subraya la importancia de intervenciones focalizadas. Se concluye que, aunque los docentes muestran disposición para mejorar sus competencias tecnológicas, es fundamental fortalecer la infraestructura y diseñar programas formativos pertinentes para maximizar el potencial de las TAC en los entornos educativos.
Minocycline Induced Black Bone Disease in Patient Presenting with Osteoarthritis of the Knee-A Case Report
Authors: Pirtle John Michael , Myers Chloe , Carlson Peyton , Conrad Sean , Ranone Valerie , Mills Amy , Hooks Bryan
Published: January 2025

This case report describes a case of minocycline induced black bone disease encountered during an elective total knee arthroplasty. Prior to the procedure, no history gleaned from the patient suggested concern for any osseous pathology aside from arthritic changes. In the operative suite, the articular cartilage and subchondral bone were noted to be hyperpigmented. Samples were taken for histopathology to rule out alkaptonuria as an alternative cause of this diffuse hyperpigmentation. In the post operative suite, the patient was able to confirm long standing use of high doses of minocycline for dermatologic purposes. No other pathological processes were noted from the operative samples taken. This case highlights the importance of thorough medical history, understanding of biochemical principles and broad-based differentials when unsuspecting findings are noted during routine cases. Exposure to, and reporting these types of cases are vital to future surgeon recognition of this disease process.
Association between factors leading to absenteeism among nurses and their job commitment in the critical care unit
Authors:   Nursing Department, King Faisal Medical Complex, Shihar Road, Alhadaek, Taif 26514, Saudi Arabia, Alzahrani Talal Jabear , Cordero Rock Pareno , Hermano Dominic ,   Nursing Department, Fakeeh College for Medical Sciences, Abdul Wahab Naib Al Haram, Al-Hamra'a, Jeddah 23323, Saudi Arabia,   Our Lady of Fatima University, 120 MacArthur Hwy, Valenzuela, 1440 Metro Manila, Philippines, Benjamin Lizy Sonia ,   College of Nursing, King Khalid University, Abha Al-Qureiger Campus, Abha, Aseer Region 62529, Saudi Arabia
Published: January 2025

Introduction: The work attitude of nurses considerably influence their productivity, work efficiency, and quality of patient care. Consequently, the association between absenteeism and job commitment is a topic of interest in most healthcare organizations, particularly in nursing, because it directly impacts patient safety, especially those in critical care units (CCUs). This study evaluated the association between factors leading to absenteeism among nurses and their job commitment in the CCU.
Methods: This study involving a correlational research design included 210 critical care nurses from a tertiary government hospital in Saudi Arabia enrolled using a non-probability convenient sampling technique. Self-administered questionnaires developed by researchers were used for the analysis.
Results: The most common factors leading to absenteeism among nurses were work routine exhaustion (mean
[M]: 2.45, standard deviation [SD]: 1.07), an uncontrolled attitude toward absenteeism (M: 2.43, SD: 1.10), family-related issues (M: 2.41, SD: 1.01), and an unhealthy working environment (M: 2.41, SD: 0.97). Moreover, the nurses also expressed low commitment to their job (composite M: 3.20, SD: 0.98). A significant association was observed between the factors leading to absenteeism among nurses in the CCU and their job commitment.
Conclusion: The factors leading to absenteeism among nurses in the CCU were exhaustion from their routine work, an uncontrolled attitude toward absenteeism, family-related problems, and an unhealthy working environment. An inadequate nursing workforce due to absenteeism may compromise the quality of care provided to patients. Understaffing due to absenteeism can also result in an over workload, fatigue, and low morale among nurses on duty. Furthermore, a lack of job commitment may affect patient outcomes and safety
COMPARISON OF INSTRUMENT-ASSISTED SOFT TISSUE MOBILIZATION TECHNIQUE AND MYOFASCIAL GUN IN UPPER CROSS SYNDROME
Authors: Siddiqui Hafsa , Muhammad Affan Iqbal  , Azka Batool  , Nemra Shah  , Saman Javaria  , Saadullah Khalid  , Aqsa Mustafa
Published: January 2025

Background: Upper Cross Syndrome (UCS) is acquired due to use of cell phones, laptops etc. Upper Trapezius is one of the primary muscles that is tightened in UCS. Myofascial release is a known method to treat UCS to relieve pain and improve cervical ranges and posture. This analyzes the effects of myofascial release of the Upper Trapezius muscle through IASTM and Myofascial Gun on pain, cervical ROMs, posture, and disability in UCS. The effects of IASTM on UCS are evident. However, Myofascial Guns are a new advancement whose effects are yet to be studied in UCS.
Objective: To determine the effects of IASTM and Myofascial Gun on pain, cervical ROM’s, Posture, and functional status in UCS.
Methods: An RCT was conducted on 30 patients with UCS. Participants were divided into two groups with 15 in each. Group A was treated with IASTM and Group B with Myofascial Gun on the upper trapezius muscle. Both groups received 3 sessions per week for 4 weeks. Assessments were taken at baseline and after 4 weeks of intervention.
Results: IASTM and Myofascial Gun both were equally effective in improving NPRS, Cervical flexion, extension, right and left rotation, right and left lateral flexion, NDI scores and tragus to wall distance after 4 weeks of intervention in UCS.
Conclusion: It is concluded that IASTM and Myofascial Gun both are equally effective in improving pain, cervical ROMs, posture and functional status in Upper Cross Syndrome.
On the Potentials of Hybrid Concert Formats
Authors: Baumann Hannah
Published: January 2025

Communication, reach and participation can take on new significance in the artistic engagement with digitality, especially when combined with analog experiences. This article reflects on the development of hybrid concert formats, exploring the dramaturgical possibilities and potentials that they can offer for the practice of music mediation.
Berggeist vom Schöckl
Authors: Wimmer Constanze , Weiss Sarah
Published: January 2025

Graz Opera and the University of Music and Performing Arts Graz developed a mobile miniature opera based on a Styrian legend, to be performed in small regional cultural initiatives in Styria. The first part with an open end took place in 15 locations, the second and final part once in the opera house in Graz. This article deals with the artistic realization of the project and illuminates the Berggeist vom Schöckl from the perspective of music mediation and ethnomusicology. Of particular interest for both fields are the conditions and approaches of audience development elaborated here in relation to the field of tension between city and countryside.
(Mis)representation of Gender in Digital Classical Music Mediation
Authors: Kirchberg Irina
Published: January 2025

Building on the research of Octobre and Patureau (2018), this article invites reflection on the treatment of gender issues in digital mediation formats developed by music mediation organizations and concert promoters. Studies in the sociology of artistic work (Coulangeon and Ravet 2003; Buscatto 2007; Bousquet et al. 2018) consistently show that music fields – be it classical, jazz, or pop – are affected by a dual gender segregation: horizontal (gender distribution based on the type of employment) and vertical (lower access to leadership positions). One might assume that producers of digital mediation formats, who advocate for values such as coexistence, social inclusion, and agency (Perez-Roux and Montandon 2014; Carrel 2017), and who are aware of the normative and prescriptive effects of educational resources (Octobre 2014), would question these boundaries. The ‘counting’ and analysis of ‘cases’ derived from the systematic examination of approximately one hundred accessible online digital formats produced by music production and dissemination organizations will demonstrate that this is not the case.
Multifaceted Concert Performances in Music Schools
Authors: Schinnerl Dagmar
Published: January 2025

Based on Andrea Welte's article "Musikschulen" in Handbuch Musikvermittlung (2023), this paper presents an approach to designing recitals at music schools and reflects on the challenges and the conditions for success mentioned by Welte. The text argues that the student engagement in tandem with limited instructor interference in concept develop-ment enables the student instrumentalists involved to participate and collaborate so that they can appear as music-mediating practitioners.
Technologies in Live Performance of Classical Music as Resource of Music Mediation
Authors: Alencar de Freitas Nívea Renata
Published: January 2025

This paper presents an overview of contemporary practices that incorporate technological tools into live classical music performances. These tools serve various functions, including enhancing sound transformation in the musical process and augmenting the aesthetic experience of performances through audiovisual elements. Drawing on international examples from large institutions and independent projects, the study highlights the evolving role of technology in classical music, particularly in fostering new forms of audience engagement and reshaping concert experiences. The analysis touches on key issues such as the declining interest in classical music, the aging audience base, and the role of non-traditional venues in broadening appeal. It also addresses how these new practices contribute to breaking away from the "rituals" of traditional concert formats, providing a fresh perspective on how classical music performances can connect with modern audiences.
Towards a Resonance-Oriented Music Mediation
Authors: Müller-Brozovic Irena
Published: January 2025

This theoretical study establishes a theoretical framework for resonance-oriented music mediation, aimed at fostering strong music experiences. It introduces a model designed to conceptualize and analyze music mediation projects that seek to initiate, broaden and deepen music relationships. First, the understanding of music is discussed and it is explained how the fields of cultural studies, the capability approach and music sociology contribute to the theoretical foundation of music mediation. Music mediation is then discussed as an umbrella term encompassing diverse practices. The second section builds on Hartmut Rosa's (2016) resonance theory, which describes resonance as a dynamic, reciprocal interaction, to establish the core principles of resonance-oriented music mediation. The proposed model, informed by additional literature, delineates (1) four dimensions of resonant music relationships, (2) their defining characteristics, (3) favorable impulses, and (4) underlying principles. These theoretical findings are illustrated with a practical example. The article concludes with a discussion of the ethical implications of resonance-oriented music mediation, emphasizing the facilitation of vibrant and transformative music relationships.
Pengaruh Service Quality, Store Atmosphere, & Product Packaging Terhadap Customer Loyalty Dengan Customer Satisfaction Sebagai Variabel Moderasi Pada Trenomina Coffe Shop Sebani Kota Pasuruan
Authors: Amirul Izzul Haq  , Eko Handayanto  , Yulist Rima Fiandari
Published: January 2025

Di Trenomina Coffee Shop Sebani, Kota Pasuruan, penelitian ini bertujuan untuk menguji secara empiris pengaruh kemasan produk, suasana toko, dan kualitas layanan terhadap loyalitas pelanggan, dengan menggunakan kepuasan pelanggan sebagai variabel moderasi. Pelanggan Trenomina Coffee Shop Sebani, Kota Pasuruan, merupakan populasi penelitian. Pelanggan yang telah melakukan dua kali atau lebih pembelian di Trenomina Coffee Shop Sebani, Kota Pasuruan, merupakan karakteristik penelitian. Pengambilan sampel secara purposive dikombinasikan dengan teknik pengambilan sampel non-probability digunakan untuk melakukan prosedur pengambilan sampel, dengan menerapkan rumus Ferdinand (populasi tidak diketahui). Perangkat lunak Partial Least Square (PLS) akan digunakan dalam penelitian ini. Temuan penelitian menunjukkan bahwa loyalitas pelanggan dipengaruhi secara positif dan signifikan oleh kualitas layanan, bahwa atmosfer toko memiliki pengaruh positif dan signifikan terhadap loyalitas pelanggan, bahwa konsumen dan kemasan produk memiliki pengaruh positif dan signifikan terhadap loyalitas pelanggan, bahwa kualitas layanan tidak berpengaruh terhadap loyalitas pelanggan, yang dimoderasi oleh kepuasan pelanggan, dan bahwa kemasan produk tidak berpengaruh terhadap loyalitas pelanggan, yang dimoderasi oleh kepuasan pelanggan.
FAKTOR- FAKTOR YANG MEMPENGARUHI RENDAHNYA MINATIBU MENJADI PENGGUNA ALAT KONTRASEPSI DALAM RAHIM (AKDR) DI DESA LUMBANJULU
Authors: Eni Monaliska Sihombing
Published: January 2025

Latar Belakang : Alat Kontrasepsi Dalam Rahim (AKDR) adalah suatu alat ataubenda yang dimasukkan kedalam Rahim yang sangat efektif, reversible danberjangka panjang, dapat dipakai pada semua perempuan usia. AKDRmerupakan suatu metode kontrasepsi yang dapat digunakan jangka panjang.Tujuan : Penelitian ini bertujuan untuk mengetahui faktor-faktor yangmempengaruhi rendahnya minat ibu menjadi pengguna alat kontrasepsi dalamrahim di desa LumbanjuluTahun 2023.Metode : Penelitian ini bersifat deskriptif, yang menggambarkan faktor- faktoryang mempengaruhi rendahnya minat ibu menjadi pengguna kontrasepsi AKDRdi Desa Lumbanjulu dengan pendekatan cross sectional .Populasi dalampenelitian ini adalah sebanyak 160 orang.Sampel dalam penelitian ini adalahsebanyak 32 orang dengan tehnik Accidental Sampling.Hasil penelitian : Berdsarkan hasil penelitian ibu yang berminat menggunakanAKDR sebanyak 12 orang (37.5%) dan tidak minat sebanyak 20 orang (62,5 %)dan dilakukan analisa uji statistik dengan metode uji chi-square diperoleh p value=0.000 dimana p hitung lebih kecil dari p tabel (p<0.05) yaitu terdapat hubunganantara variable yang diteliti.Kesimpulan : Dalam penelitian ini dapat disimpulkan bahwa pengetahuan ,dukungan suami dan dukungan petugas kesehatan sangat mempengaruhi minatibu sebagai penggunaAKDR dan juga membantu dalam mengambil keputusansebagai pengguna AKDR, hal ini di buktikan dengan hasil uji statistik dengan Pvalue 0,000 yang menyatakan bahwa varibal bebas mempengaruhi variabelterikat.Kata Kunci : Pengetahuan , Dukungan Suami Dan Dukungan PetugasKesehatan, Minatpengguna AKDR
HUBUNGAN PENGETAHUAN DENGAN SIKAP REMAJA PUTRI TENTANG PERNIKAHAN DINI DI SMK N.1 LINTONGNIHUTA KELAS X
Authors: Eni Monaliska Sihombing
Published: January 2025

Latar Belakang : Menurut World Health Organization (WHO) tahun 2017,

sebanyak 14,2
juta
anak
perempuan
setiap
tahunnya
akan
menikah

pada
usia
muda. Di
Asia
Selatan,
hampir
setengah
dari
perempuan

muda
dan
di
Afrika lebih dari sepertiga perempuan muda menikah pada usia

18 tahun.Tujuan : Penelitian ini bertujuan untuk Untuk mengetahui Hubungan Pengetahuandengan sikap remaja putri tentang pernikahan dini di SMK N.1 Lintongnihuta kelasXMetode : Penelitian ini menggunakan metode Deskriptif Analitik denganpendekatan Cross Sectional. .Populasi dalam penelitian ini adalah sebanyak 30orang.Sampel dalam penelitian ini adalah sebanyak 30 orang dengan tehnik totalsampling.Hasil penelitian : Berdasarkan hasil penelitian dari 30 orang responden yangmemiliki pengetahuan tidak baik tentang pernikahan dini sebanyak 17 responden(56,7%) dimana sikap remaja tentang pernikahan dini yang bersikap positifsebanyak 15 orang (50,0%) dan yang bersikap negatif sebanyak 2 orang(6,7%)sedangkan responden yang memiliki pengetahuan baik tentang pernikahandini sebanyak 13 orang (43,3 %) dimana sikap remaja tentang pernikahan dini yangbersikap positif sebanyak 3 orang (10,0%) dan yang bersikap negatif sebanyak10(33,3) orang.dan dilakukan analisa uji statistik dengan metode uji chi-squarediperoleh p value =0.000 dimana p hitung lebih kecil dari p tabel (p<0.05) yaituterdapat hubungan antara variable yang diteliti.Kesimpulan : Dalam penelitian ini dapat disimpulkan bahwa ada hubunganpengetahuan dengan sikap remaja putri tentang pernikahan dini di SMK N.1Lintongnihuta dengan uji statistik chi square nilai P value0.000 yang menunjukkanada hubungan yang erat antara variabel yang ditelitiKata Kunci : Pengetahuan Remaja , Sikap Remaja Dan Pernikahan Dini
Karakteristik Ibu Hamil dengan Ketuban Pecah Dini Di Rs. Setio Husodo Kisaran
Authors: Nani Jahriani  , Ika Lestari  , Eva Karisma
Published: January 2025

Ketuban pecah dini adalah pecahnya selaput ketuban sebelum terjadiproses persalinan yang dapa terjadi pada usia kehamilan cukup waktu ataukurang waktu. Ketuban pecah dini merupakan salah satu penyebab infeksimamaupun neonatal, persalinan prematur, hipoksia, defermitas janin,meningkatnya insiden SC, atau gagalnya persalinan Normal. Penelitian inibertujuan untuk mengetahui bagaimana karakteristik ibu hamil dengan ketubanpecah dini berdasarkan usia, paritas, dan pekerjaan, di RS Setio Husodo Kisaran.Dari survey awal peneliti mendapatkan data dari rekam medik rumah sakit RSSetio Husodo Kisaran, ditemukan ketuban pecah dini sebanyak 99 ibu. Penelitianini bersikap deskristif, dengan menggunakan dat skunder yang dapat di medicalrocord RS Setio Husodo Kisaran“ Terdapat populasi sebanyak 99 kasus dansempel dalam penelitian ini adalah keseluruhan populasi yaitu 99.Ketuban pecahdini banyak dijumpai pada wanita hamil > 35 tahun sebanyak 39 kasus (39,4 %),kasus ketuban pecah dini mayoritas terjadi pada ibu hamil multipara sebanyak22 (22.2 %), kasus ketuban pecah dini pada ibu hamil yang bekerja mayoritasIRT 40 ( 40,4%).Berdasarkan hasil penelitian dapat disimpulkan bahwa ketuban pecah dinibanyak ditemukan pasa usia > 35 tahun, maka dianjurkan pada ibu hamil lebihmenjaga kesehatannya karena usia > 35 tahun dimana organ reproduksi danfungsi organ tubuh lainya sudah mulai menurun, sehingga rahim ibu tidak dapatbekerja dengan baik.Kata Kunci: Karakteristik, Ibu hamil, Ketuban Pecah Dini
Implementation of Physics Education Technology (Phet) Media on Student’s Science Concept Understanding: A Literature Review
Authors: Putri Neli Suryani , Resti Yektyastuti  , Yusuf Safari
Published: January 2025

Physics Education Tehcnology (Phet) media has been widely utilized in science learning which helps students in understanding abstract concepts more easily. The purpose of this literature study is to ascertain whether Phet media can contribute to improving students' understanding of science concepts more significantly. This research uses a literature review methodology. The results of the review show that Phet media has significant potential to improve students' understanding of science concepts. Phet's interactive and visual simulations assist students in developing deeper and lasting understanding and encourage them to learn actively and independently. Overall, this literature study supports the use of Phet media in science learning to improve concept understanding and learning quality.
Early Childhood Education in Surah Maryam: Perspective of Tafsir Al-Qurthubi
Authors: Sofiani Indah , Mahfud Mahfud , Anshorullah Arich H.
Published: January 2025

In discussions about education, early childhood education has become a primary focus. The question is, when is the ideal time to begin this education? While many believe that education starts after a child enters school or preschool, research indicates that education actually begins during pregnancy. Al-Qur’an, as the guiding principle for Muslims, emphasizes the importance of early education. Therefore, studying Al-Qur’an is an obligation for every Muslim. This study focuses on early childhood education based on the Surah Maryam (Chapter of Mary) in the commentary by Imam Al-Qurthubi. The research method employed is a literature review using primary data from Al-Qurthubi’s Tafsir. The findings reveal that early childhood education, according to Al-Qurthubi, particularly in Surah Maryam verse 12, centers around Al-Qur’an education. Memorizing and practicing Al-Qur’an are integral parts of this education. Al-Qur’an education should ideally commence during early childhood, around the ages of 2-3 years. At this stage, it is crucial to introduce children to the oneness of Allah (Tawhid) and teach them the fundamental declaration of faith (Kalimat Tauhid). This research provides fresh insights into early childhood education within Islam. By studying Al-Qur’an from an early age, it is hoped that children will grow into individuals who are faithful and possess noble character.
Cell membrane glycan contents are biochemical factors that constitute a kinetic barrier to viral particle uptake in a protein-nonspecific manner
Authors: Kaizuka Yoshihisa , Machida Rika
Published: January 2025

Various types of glycoproteins have been suggested to inhibit viral infection of cells via steric repulsion. However, it is difficult to evaluate such physical actions genetically, simply because they are nonspecific and can be caused by any molecule. Therefore, we investigated a method to compare this nonspecific action among cells with diverse membrane protein profiles. We found that a wide range of glycoproteins individually had a strong inhibitory effect on infection, while on the other hand, the total amount of glycans was negatively correlated with the infection level in each cell. Thus, the infection-inhibitory effect of glycoproteins was molecularly nonspecific, but was additively enhanced according to the amount of glycans on the cell surface. In this correlation, glycans function as a fundamental factor. Further investigating the mechanism by which glycans function as a factor in infection control, we conclude that the repulsion between proteins created by branched glycans forms a kinetic energy barrier against packing the virus into the region of protein interstitial space. As a result, the formation of the adhesive interface between the virus and the cell membrane, which is necessary for infection, is inhibited. This study attempted to link the cell’s nonspecific physical properties with intracellular biochemicals. A similar approach may be applied to quantify other nonspecific biological phenomena.
Redefining School Curriculum through the Lens of P. R. Sarkar’s Neo-Humanism
Authors: Ghosh Subhendu , Shinde Dhiraj , Sarkar Ratan
Published: January 2025

This paper explores the integration of P. R. Sarkar's Neo-Humanism philosophy into school curricula as a transformative approach to education. Neo-Humanism emphasizes holistic development, focusing on intellectual, emotional, social, and spiritual growth beyond traditional academic achievement. The paper discusses key principles of Neo-Humanism in education, including holistic development, universal human values, inclusivity, ecological awareness, and spiritual growth. It outlines strategies for implementing these principles in school curricula, such as integrating value-based education, incorporating emotional and social learning, focusing on sustainability and global citizenship, adopting inclusive education practices, and encouraging ethical reflection. The paper also addresses challenges in implementing Neo-Humanism, including resistance to change, teacher training needs, development of new materials, balancing academic rigor with holistic development, and resource constraints. Despite these challenges, the authors argue that Neo-Humanism offers a crucial framework for preparing students to navigate the complexities of the 21st century, fostering empathy, ethical reasoning, and social responsibility. The paper concludes that adopting Neo-Humanist principles in education can produce well-rounded, morally responsible citizens capable of contributing to social justice, environmental sustainability, and global peace.
Dynamic Analysis of an Exponentially Decaying Foundation on the Response of Non-Uniform Damped Rayleigh Beam under Harmonic Moving Load with General Boundary Conditions
Authors: N. P. Okafor , T. A. Ogunlusi , F. T. Ogunwe , A. I. Ayobami
Published: January 2025

This study investigates the dynamic response of a non-uniform damped Rayleigh beam on an exponentially decaying foundation subjected to a harmonic moving load with general boundary conditions. The governing equation, a fourth-order non-homogeneous partial differential equation with variable coefficients, is discretized using the Generalized Galerkin Method. Two cases are examined: moving force and moving mass. Closedform solutions are obtained for the moving force case using Laplace transform in conjuction with convolution theorem. For the moving mass case, the Struble asymptotic method cannot simplify the equation for the moving mass case due to the variable load magnitude, and thus, Runge-Kutta method of order four (RK4) is employed to obtain a numerical solution. Analytical and numerical solutions are compared for validation of accuracy of the Runge-kutta scheme and found compared favourably. The effects of some key structural parameters on dynamic behavior are examined, and resonance conditions are established.
Prevalence of COVID-19 Vaccine Hesitancy and Its Associated Factors among Health Care Workers in Imo State, Nigeria
Authors: Ahaneku Ekenedirichukwu Blasingame , Okonkwo Chukwuebuka Ifeanyi , Ezika Chinedu Anthony , Ewuru Sebastine Nnamdi , Iyeh Uchenna John , Madukwe Jesuspower C. , Ogbusu Darlyn Chioma
Published: January 2025

Background: Vaccine hesitancy is an important public health concern which leaves healthcare workers at a high risk of getting infected with COVID-19. The lack in acceptance of COVID-19 vaccine sets the stage for increased morbidity and mortality among every age group globally. Therefore, acceptance of the vaccine is an effective strategy and major role in combating COVID-19 pandemic.
Objectives: To determine the prevalence of COVID-19 vaccine hesitancy among Health Care Workers in Imo state, Nigeria.
Methodology: The study was a descriptive cross-sectional study on the prevalence of COVID-19 vaccine hesitancy and its associated factors among HCWs in Federal Medical Centre, Owerri and Imo State University Teaching Hospital, Orlu. An electronic survey heart questionnaire was used to collect data. Data was analyzed using IBM Statistical Package for Social Science v23 and the result was presented using frequencies and proportions.
Results: The overall prevalence of hesitant among HCWs in Imo state is 35.4%. The majority of the participants are female (54.2%) single (53.6 %) and with a first degree as the highest level of education (70.9%) A higher proportion of Non-Vaccine hesitant compared to vaccine hesitant reported that COVID 19 infection is real, (96.9%, 81.3%); A higher proportion of Vaccine hesitant compared to non-vaccine hesitant reported that they do not trust information from the internet/social media about COVID-19 and vaccine, (80.5%, 64.7%); that information from internet/social media made them worry about taking vaccine, (65.0%, 58.5%); that they feel there isn’t enough information about vaccine and its safety, (54.5%, 42.9%); A higher proportion of Non-Vaccine hesitant compared to vaccine hesitant reported that their consideration for the vaccine depend on how safe it is perceived, (84.4%, 80.5%); that their consideration for the vaccine depend on how long it has been tested, (74.6%, 69.6%); A higher proportion of Vaccine hesitant compared to non-vaccine hesitant reported that their consideration for the vaccine does not depend on the vaccine cost, (78.9%, 71.9%).
Conclusion: In this study approximately 1 out of every 3 HCWs surveyed reported being vaccine hesitant. Having hesitant among HCWs is a drawback to the success of the ongoing mass vaccination and COVID-19 eradication.
Optimizing Planting Date and Spacing for Enhanced Yield and Oil Production of Kaempferia galanga L.: A Field Experiement
Authors: P. V Sindhu , C Beena , P. Sindhumole
Published: January 2025

Kaempferia galanga L., a rhizomatous plant species, is highly valued for its medicinal and culinary properties. Studying the effects of planting dates and spacing is crucial for optimizing the cultivation of K. galanga, as it can help farmers and cultivators maximize yields, improve resource allocation, and promote sustainable agricultural practices. This study investigated the impact of planting date and spacing on the growth and yield of K. galanga. The experiment was conducted over three consecutive years, with three planting dates (April 15, April 30, and May 15) and four spacing treatments (20 cm x 20 cm, 30 cm x 30 cm, 40 cm x 40 cm, and 50 cm x 50 cm). The results showed that planting date and spacing significantly affected canopy diameter, yield per plant, rhizome yield per hectare, and oil yield per hectare. The optimal planting window for maximizing yield and oil production was April 15-30, with a spacing of 20 cm x 20 cm. Wider spacing resulted in higher yield per plant, while closer spacing led to higher rhizome yields per hectare.
The Effectiveness of Tzuyu as a Brand Ambassador in launching Pond’s Bright Miracle Products on @pondsindonesia Followers
Authors: Kalla Rachel Ade Suryaning , Indrayani Inri Inggrit , Budiana Daniel
Published: January 2025

This study aims to measure the effectiveness of Tzuyu as a brand ambassador in launching Pond's bright miracle products on the @pondsindonesia Instagram account. A brand ambassador is someone who is the representative or face of a brand used by companies to communicate and connect with the public. The use of popular celebrities as brand ambassadors in product launches will attract greater attention. Tzuyu is a member of one of the famous girl groups in South Korea, Twice. Pond's appointed Tzuyu as a brand ambassador in the launch of Pond's bright miracle product by using Instagram social media as a tool to convey messages to the audience. This study measures the effectiveness of a brand ambassador using the theory of source credibility by Ohanian (1990). This research uses a descriptive quantitative approach with data collection techniques using an online questionnaire via google form. The purposive sampling technique is in accordance with the criteria determined in selecting respondents who fill out the questionnaire. The results showed that Tzuyu as Pond's brand ambassador in the launch of Pond's bright miracle was declared effective, with attractiveness being the most effective indicator.
The Representation of Women Empowerment on The Little Mermaid Movie
Authors: Rikhana Priscilla Christy , Lesmana Fanny , Wijayanti Chory Angela
Published: January 2025

The Little Mermaid Movie tells the story of Ariel’s journey to seek freedom and achieve her dream to be a part of the human world. This research explores the representation of women empowerment in the film using John Fiske's semiotic method, broken down into three levels, reality, representation, and ideology. The study employs a descriptive qualitative approach, with the object being the representation of women empowerment and the subject being the film The Little Mermaid. The findings reveal that the women empowerment exhibited by Ariel, the protagonist of the film, is articulated through three categories: women empowerment in making life choices, achieving equality in society, and fostering social change. These categories align with the stages of women empowerment, personal level, interpersonal level, and social action & social change. Furthermore, it is evident that the depiction of a woman with a special status, such as a double minority, can empower individuals with similar statuses who view the film. Additionally, the ideologies of revisionism and feminism are identified in the process of women empowerment depicted in the film.
Automated Image Analysis for Characterization of Circulating Tumor Cells and Clusters Sorted by Magnetic Levitation
Authors: Ogut Mehmet Giray , Ma Peng , Gupta Rakhi , Hoerner Christian R. , Fan Alice C. , El‐Kaffas Ahmed Nagy , Durmus Naside Gozde
Published: July 2023

Magnetic levitation‐based sorting technologies have revolutionized the detection and isolation of rare cells, including circulating tumor cells (CTCs) and circulating tumor cell clusters (CTCCs). Manual counting and quantification of these cells are prone to time‐consuming processes, human error, and inter‐observer variability, particularly challenging when heterogeneous cell types in 3D clusters are present. To overcome these challenges, we developed "Fastcount," an in‐house MATLAB‐based algorithm for precise, automated quantification and phenotypic characterization of CTCs and CTCCs, in both 2D and 3D. Fastcount is 120 times faster than manual counting and produces reliable results with a ±7.3% deviation compared to a trained laboratory technician. By analyzing 400 GB of fluorescence imaging data, we showed that Fastcount outperforms manual counting and commercial software when cells are aggregated in 3D or staining artifacts are present, delivering more accurate results. We further employed Fastcount for automated analysis of 3D image stacks obtained from CTCCs isolated from colorectal adenocarcinoma and renal cell carcinoma blood samples. Interestingly, we observed a highly heterogeneous spatial cellular composition within CTCCs, even among clusters from the same patient. Overall, Fastcount can be employed for various applications with lab‐chip devices, such as CTC detection, CTCC analysis in 3D and cell detection in biosensors.
A Smart DNA‐Based Nanosystem Containing Ribosome‐Regulating siRNA for Enhanced mRNA Transfection
Authors: Lv Zhaoyue , Huang Mengxue , Yang Jing , Li Peiran , Chang Lele , Tang Qianyun , Chen Xiaojing , Wang Shengqi , Yao Chi , Liu Peifeng , Yang Dayong
Published: July 2023

Messenger RNA (mRNA) transfection is the prerequisite for the application of mRNA‐based therapeutics. In hard‐to‐transfect cells, such as macrophages, the effective transfection of mRNA remains a long‐standing challenge. Herein, a smart DNA‐based nanosystem is reported containing ribosome biogenesis‐promoting siRNA, realizing efficient mRNA transfection in macrophages. Four monomers are copolymerized to form a nanoframework (NF), including N‐isopropylacrylamide (NIPAM) as the skeleton and acrydite‐DNA as the initiator to trigger the cascade assembly of DNA hairpins (H1‐polyT and H2‐siRNA). By virtue of the phase transition characteristic of polymeric NIPAM, below the lower critical solution temperature (LCST, ≈34 °C), the NF swells to expose polyT sequences to hybridize with the polyA tail of mRNA. Above the LCST, the NF deswells to encapsulate mRNA. The disulfide bond in the NF responds to glutathione, triggering the disassembly of the nanosystem; the siRNA and mRNA are released in response to triphosadenine and RNase H. The siRNA down‐regulates the expression of heat shock protein 27, which up‐regulates the expression of phosphorylated ribosomal protein S6. The nanosystem shows satisfactory mRNA transfection and translation efficiency in a mouse model. It is envisioned that the DNA‐based nanosystem will provide a promising carrier to deliver mRNA in hard‐to‐transfect cells and promote the development of mRNA‐based therapeutics.
Distinct transcriptomic responses to Aβ plaques, neurofibrillary tangles, and APOE in Alzheimer's disease
Authors: Das Sudeshna , Li Zhaozhi , Wachter Astrid , Alla Srinija , Noori Ayush , Abdourahman Aicha , Tamm Joseph A. , Woodbury Maya E. , Talanian Robert V. , Biber Knut , Karran Eric H. , Hyman Bradley T. , Serrano‐Pozo Alberto
Published: July 2023

INTRODUCTION

Omics studies have revealed that various brain cell types undergo profound molecular changes in Alzheimer's disease (AD) but the spatial relationships with plaques and tangles and APOE‐linked differences remain unclear.

METHODS

We performed laser capture microdissection of amyloid beta (Aβ) plaques, the 50 μm halo around them, tangles with the 50 μm halo around them, and areas distant (> 50 μm) from plaques and tangles in the temporal cortex of AD and control donors, followed by RNA‐sequencing.

RESULTS

Aβ plaques exhibited upregulated microglial (neuroinflammation/phagocytosis) and downregulated neuronal (neurotransmission/energy metabolism) genes, whereas tangles had mostly downregulated neuronal genes. Aβ plaques had more differentially expressed genes than tangles. We identified a gradient Aβ plaque > peri‐plaque > tangle > distant for these changes. AD APOE ε4 homozygotes had greater changes than APOE ε3 across locations, especially within Aβ plaques.

DISCUSSION

Transcriptomic changes in AD consist primarily of neuroinflammation and neuronal dysfunction, are spatially associated mainly with Aβ plaques, and are exacerbated by the APOE ε4 allele.
Bilateral vocal cord palsy induced by long‐term use of small‐bore nasogastric tube
Authors: Nihira Takashi , Fukaguchi Kiyomitsu , Taguchi Azusa , Fukui Hiroyuki , Sekine Ichiro , Yamamoto Daisuke , Moriya Hidekazu , Yamagami Hiroshi
Published: July 2023

Background

Nasogastric tube syndrome is a rare but life‐threatening complication of nasogastric tube placement due to acute upper airway obstruction caused by bilateral vocal cord paresis.

Case Presentation

An 86‐year‐old woman was brought to the emergency department with acute stridor. She had been diagnosed with stroke 106 days prior, and an 8F nasogastric tube was placed on the day following the diagnosis. A laryngeal fiberscopy revealed bilateral laryngeal edema and bilateral vocal cord palsy. Nasogastric tube removal and intubation were carried out, and the stridor disappeared. Two days later, a tracheostomy was performed. Unfortunately, the patient's vocal cord function had not improved at the 1 month follow‐up upon assessment with a laryngeal fiberscope.

Conclusion

Long‐term small‐bore nasogastric tube placement can cause upper airway obstruction due to bilateral vocal cord palsy.