bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Pertumbuhan Penerimaan Pajak Parkir Di Bandara Sentani Kabupaten Jayapura
Authors: Urip Transna Putra , Thayeb Mohammad Savers Oryza , Indahyani Rachmaeny
Published: May 2022

Penelitian ini bertujuan untuk mengetahui: 1) persepsi pengguna layanan parkir (wajib Pajak) terhadap layanan pajak parkir di Bandara Sentani, 2) tingkat efektifitas pajak parkir di Bandara Sentani Kabupaten Jayapura, 3) pertumbuhan penerimaan pajak parkir di Bandara Sentani, 4) upaya peningkatan penerimaan pajak parkir guna meningkatkan Pendapatan Asli Daerah Kabupaten Jayapura. Metode analisis yang digunakan adalah deskripsi kuantitatif, Alat analisis yang digunakan dalam penelitian ini adalah Interpretasi Skor yaitu dengan melihat kategori tingkat persepsi terbagi menjadi 5 yaitu sangat baik, baik, kurang baik, tidak baik, dan sangat tidak baik, dan juga perhitungan efektifitas serta perhitungan pertumbuhan penerimaan pajak parkir. Hasil penelitian menunjukkan: 1) persepsi penguna layanan parkir (wajip pajak) terhadap layanan Pajak Parkir di Bandara Sentani (Kendaraan Roda Empat) adalah dengan interpretasi skor yaitu jumlah skor 71,04% adalah rata-rata skor Baik. Sedangkan (Kendaraan Roda Dua) adalah dengan interpretasi skor yaitu jumlah persepsi 72,30% adalah rata-rata skor Baik, 2) efektivitas pajak parkir bandara sentani terhadap pendapan asli daerah di Kabupaten Jayapura tahun 2013 – 2017 bervariasi, yaitu sangat efektif terjadi di tahun 2014 dan 2017 sebesar 127,50% dan 102,3%, efektif terjadi di tahun 2013 yaitu sebesar 92,62%, kurang efektif terjadi pada tahun 2016 yaitu sebesar 61,39%, dan tidak efektif terjadi di tahun 2015 yaitu sebesar 55,86%, 3) pendapatan pajak parkir bandara sentani tahun 2013 – 2017 mengalami peningkatan. Peningkatan pendapatan pajak parkir bandara bandara sentani tertinggi terjadi pada tahun 2017 yaitu sebesar Rp. 366.568.600 dengan tingkat pertumbuhan sebesar 0,67%. Sedangkan pendapatan pajak parkir bandara sentani terendah terjadi pada tahun 2015 yaitu sebesar Rp 217.883.740 dengan tingkat pertumbuhan sebesar –0,43%, 3) upaya peningkatan pajak parkir bandara sentani yaitu dengan peningkatan penarikan tarif parkir dengan persepsi rata-rata mampu jika harga naik Rp.1.000 untuk kendaraan roda 4 dan persepsi rata-rata mampu jika harga naik Rp.500 untuk kendaraan roda 2. Sedangkan upaya lain peningkatan pajak parkir dalam meningkatkan pendapan asli daerah yaitu menaikan tarif parker dan memperluas lahan parkir antara lain dengan membuat area parkir bertingkat.Kata Kunci : Persepsi, Efektivitas, Pertumbuhan, Pajak Parkir, Pendapatan Asli Daerah
Analisis Persepsi Masyarakat Terhadap Pengenaan Pajak Kendaraan Bermotor Di Kota Jayapura
Authors: Rumbouw Abika Cahyan , Urip Transna Putra , Sanggrangbano Agustina
Published: May 2022

Sesuai dengan permasalahan yang telah dirumuskan, adapun tujuan dari penelitian ini yaitu mengetahui persepsi masyarakat terhadap pengenaan pajak kendaraan bermotor dalam pelayanan proses pembayaran pajak kendaraan bermotor dan persepsi masyarakat dengan adanya peraturan tarif baru pajak kendaraan bermotor di Kantor SAMSAT Kota Jayapura. Hasil penelitian menunjukkan bahwa Persepsi masyarakat terhadap pengurusan pajak di Kantor SAMSAT Kota Jayapura yang terdiri dari kemudahan pelayanan, kesesuaian persyaratan, kejelasan pelayanan, kedisiplinan pegawai, tanggung jawab pegawai, kesiapan pegawai, keadilan dalam memberikan pelayanan dan kesopanan serta keramahan secara keseluruhan diperoleh nilai rata-rata sebesar 76,87% dan termasuk pada kategori kurang baik. Persepsi masyarakat terhadap peraturan tarif kendaraan bermotor yang terdiri dari tarif yang ditetapkan, tingkat kewajaran tarif dan tarif denda pajak tergolong masih sesuai dengan kemampuan dan kondisi masyarakat khususnya di Kota Jayapura diperoleh nilai rata-rata sebesar 82,22% dan termasuk pada kategori baik.Kata Kunci : Persepsi Masyarakat, Pengenaan Pajak Kendaraan Bermotor
Partisipasi Masyarakat Dalam Pengelolaan Dana Desa Di Kampung Tablasupa Distrik Depapre Kabupaten Jayapura
Authors: Patty Richard , Setiawan Agus , Urip Transna Putra
Published: May 2022

Penelitian ini bertujuan untuk mengetahui tentang partisipasi masyarakat dan untuk mengetahui faktor-faktor yang mempengaruhi partisipasi masyarakat di bidang pelaksanaan pembangunan di Kampung Tablasupa. Pengambilan sampel dilakukan mengunakan “metode purposive sampling’ atau memilih secara sengaja dengan mempertimbangkan bahwa responden yang dipilih dianggap banyak mengetahui tentang partisipasi masyarakat dalam pengelolaan dana desa, teknik pengumpulan data melalui wawancara dan dokumentasi. Metode analisis data yang digunakan yaitu teknik analisis deskriptif dengan pendekatan kualitatif. Hasil penelitian ini, menunjukan bahwa partisipasi masyarakat dalam pengelolaan dana desa dibidang pelaksanaan pembangunan di Kampung Tablasupa kurang maksimal, atau cukup baik pada perencanaan dan kurang baik pada pelaksanaan dan pengawasan pada program kegiatan-kegiatan kampung, hal ini di sebabkan karena faktor kesadaran/kemauan, faktor informasi, dan faktor pekerjaan masyarakat.Kata Kunci: Partisipasi Masyarakat, Pelaksanaan Pembangunan Kampung.
Studi geomorfologi Daerah Samaturu, Kabupaten Kolaka, Provinsi Sulawesi Tenggara
Authors: Hasrul Hasrul , Hasria Hasria , Asfar Suryawan
Published: May 2022

Administratively, the research area is in the Samaturu area, which includes three villages; Liku Village, Lawulo Village, and Puulawulo Village, which belong to Kolaka Regency, Southeast Sulawesi Province. Geographically, the study area is limited by 3˚58’30”-4˚1’00” LS and 121˚27’30”-121˚29’20” BT. The study area has a length of 5 km and a width of 5 km, with an area of 2.500 Ha. The purpose of this study was to determine the geomorphological conditions in the Samaturu area, Kolaka Regency, Southeast Sulawesi Province. The research method used is the DEMNAS image interpretation method and direct observation in the field to study and determine the geomorphological conditions in the study area. The result showed that the geomorphological conditions of the study area were divided into two units. The units observed were structural form units with the hills of fault zones and fluvial origin with alluvium landscapes. Flow patterns that develop in the study area are rectangular and concerted with young to adult geomorphological stages
USOS DOS RESULTADOS DAS AVALIAÇÕES EXTERNAS PELAS SECRETARIAS DE EDUCAÇÃO, GESTORES ESCOLARES E PROFESSORES: ANÁLISE DA PRODUÇÃO CIENTÍFICA PUBLICADA NO BRASIL (2008-2018)
Authors: Borges Regilson Maciel , Carvalho Karolayne Rezende de , Freitas Thaís Mariana de , Mendonça Eder Adriano
Published: May 2022

The research aimed to analyze the scientific production published in scientific articles, theses, dissertations and event proceedings on the uses of the results of external evaluations by the departments of education, school managers and teachers, seeking to understand how the authors of the productions analyzed point out that these instances of education networks appropriate the results of these evaluations. Methodologically, this is a bibliographic study, which was carried out in the Scientific Electronic Library Online (SciELO) databases and in the Portal Educ@ online education publications of the Carlos Chagas Foundation (articles), in the Brazilian Digital Library of Theses and Dissertations (BDTD) (theses and dissertations) and on the websites of the National Association of Education Policy and Administration (ANPAE) and the National Association for Research and Graduate Studies (ANPEd) (annals of events), having as search descriptors the words "external evaluation”, “secretariat of education/managers/teachers” and “use of results”. The results of the survey on the uses of the results of the external evaluation pointed to 12 studies referring to the departments of education, 8 studies focusing on school management and 10 dealing with uses by teachers, totaling 27 productions, considering that 3 works are repeated in the analyzed focuses. External assessment is centralized and predominantly focuses on student performance. These assessments are mainly based on Portuguese Language and Mathematics contents, which ends up leading to a narrowing of the curriculum, which also end up signaling the investment of education departments, school management and teachers in contents that will be charged for in exams carried out by the government.
Tectonic Collision, Orogeny and Geothermal Resources in Taiwan
Authors: Lee Chao-Shing , Hutchings Lawrence , Wang Shou-Cheng , Jarpe Steve , Syu Sin-Yu , Chen Kai
Published: May 2022

The recent tectonic evolution of Taiwan created ideal conditions for geothermal resources: heat, water and permeability. We examine heat flow measurements, seismic tomography, seismicity, hot spring distribution, tectonic history, geology, and volcanism described in previous studies to understand the relation between tectonics and geothermal potential in Taiwan. Taiwan is the youngest tectonically created island on earth. The island formed as a result of the transition from subduction of the Eurasian Plate under the Philippine Sea plate to active collision. Collision results in orogenic mountain building. The geology of the island is primarily an accretionary prism from the historic subduction. This active orogeny creates unusually high geothermal gradients by exhumation of the warmer material from depth and by strain heating. As a result, temperatures reach up to ~200 degree C. Volcanoes in the northern tip of Taiwan provide an additional source of heat. Favorable fluid flow from meteoric waters and permeability from seismicity and faulting results in exploitable geothermal systems near the surface. These systems can potentially provide geothermal power generation throughout the whole island, although there are currently only two geothermal power plants in Taiwan.
Conventional and Unconventional Transformation of Cocoa Pod Husks into Value-Added Products
Authors: Francisca Baidoo Martina , Yaw Asiedu Nana , Darkwah Lawrence , Arhin-Dodoo David , Zhao Jun , Jerome Francois , Nana Amaniampong Prince
Published: May 2022

The drive for a sustainable society and a circular economy has motivated researchers around the globe to turn to the transformation of renewable raw materials like biomass into value-added products that are akin or superior to their fossil counterparts. Among these biomass raw materials, cocoa pod husks (CPH) which is the non-edible portion of cocoa (ca. 70–75% weight of the while cocoa fruit) remains a promising bio-resource raw material for the production high-value added chemicals but yet largely underexploited. Currently, the most popular applications of CPH involves its use as low-value application products such as animal feed, raw material for soap making, and activated carbon. However, the rich source of lignocellulosic content, pectin, and phenolic compounds of CPH means it could be used as raw materials for the production industrially relevant platform chemicals with high potential in the agrochemicals, pharmaceutical, and food industries, if efficient transformations routes are developed by scientists. In this chapter, we will shed light on some of the works related to the transformation of CPH into various value-added products. An economic evaluation of the transformation of cocoa pod husk into relevant chemicals and products is also discussed.
Efflux Pumps among Urinary E. coli and K. pneumoniae Local Isolates in Hilla City, Iraq
Authors: Al-Dahmoshi Hussein , A. Ali Sahar , Al-Khafaji Noor
Published: May 2022

Urinary tract infections (UTI) are the most common bacterial infections affecting humans. Escherichia coli and Klebsiella pneumoniae were common enterobacteria engaged with community-acquired UTIs. Efflux pumps were vital resistance mechanisms for antibiotics, especially among enterobacteria. Overexpression of an efflux system, which results in a decrease in antibiotic accumulation, is an effective mechanism for drug resistance. The ATP-binding cassette (ABC) transporters, small multidrug resistance (SMR), and multidrug and toxic compound extrusion (MATE) families, the major facilitator superfamily (MFS), and the resistance-nodulation- cell division (RND) family are the five superfamilies of efflux systems linked to drug resistance. This chapter highlights the results of studying the prevalence of efflux pump genes among local isolates of E. coli and K. pneumoniae in Hilla City, Iraq. class RND AcrAB-TolC, AcrAD-TolC, and AcrFE-TolC genes detected by conventional PCR of E. coli and K. pneumoniae respectively. The result revealed approximately all studied efflux transporter were found in both E. coli and K. pneumoniae in different percentages. Biofilm formation were observed in 50(100%) of K. pneumoniae and 49(98%) of E. coli isolates were biofilm former and follow: 30(60%), 20(40%) were weak, 12(24%), 22(44%) were moderate and 7(14%) and 8(16%) were Strong biofilm former for E. coli and K. pneumoniae, respectively.
An Examination of Safe Injection Sites and Ethical Issues in Philadelphia, United States
Authors: A. Clark Peter , Grana David
Published: May 2022

The opioid epidemic in the United States has been an ever-increasing public health crisis. Despite being a major issue in the United States for decades, relatively little action has been taken to address the opioid crisis. To mitigate the harm the opioid epidemic has caused in the United States, safe injection sites have emerged as a promising solution. Despite the exhaustive benefits of safe injection sites, including the reduction in the number of opioid overdose deaths, safe injection sites have faced opposition in the United States. Most of these concerns in the United States question the legality of safe injection sites, along with potential community implications. Through examining the ethics of safe injection sites from a Catholic social teaching perspective and performing an integrative literature review, safe injection sites are clearly ethical and would aid in respecting the dignity and life of people who inject drugs (PWID). With safe injection sites being ethical and recommendations in this paper to overcome concerns about safe injection sites, safe injection sites are a viable option to combat the opioid crisis in the United States.
Analysis of Osteoporosis by Electron Microscopy
Authors: Nenden Mulyaningsih Neng , Sapundani Rum
Published: May 2022

Osteoporosis is a skeletal disorder characterized by decreased bone strength which affects the increased risk of fracture. Emerging evidence discovered that osteoporosis is associated with reduced bone density and bone quality. Therefore, analysis of bone morphology can afford insight into the characteristics and processes of osteoporosis. Electron microscopy, one of the best methods, can directly provide ultrastructure evidence for bone morphology. Here, we describe an experimental procedure for electron microscopy preparation and analysis of the resulting images, especially scanning and transmission electron microscopes, to analyze bone morphology in animal models of rats. Compared to other bone analyzers such as atomic absorption spectrophotometer, ultraviolet–visible spectroscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, and X-ray diffraction, scanning and transmission electron microscopes are still important to strengthen visual analysis, and a better understanding of this method could be significant to examine bone morphology.
Assessment of Oral Manifestations and Oral Health in Hospitalized Patients with COVID-19: Machine Learning and Statistical Analysis
Authors: Manifar Soheila , Koopaie Maryam , Karimi Farani Ali , Davoudi Mansour , Kolahdouz Sajjad
Published: May 2022

Background: This study aimed to investigate the oral health presentations of coronavirus disease 2019 (COVID-19) inpatients using statistical analysis and machine learning methods before infection, during hospitalization, and after discharge from the hospital. Methods: This cross-sectional study was conducted on 140 hospitalized COVID-19 patients with reverse transcription-polymerase chain reaction diagnosis and severe symptoms. Demographic data, clinical characteristics, oral health habits, and oral manifestations in three periods (i.e., before infection, during hospitalization, and after discharge from the hospital) were recorded through a questionnaire and oral examination. Statistical analysis and machine learning methods were used for the analysis of patients’ data. Results: Xerostomia, dysgeusia, hypogeusia, halitosis, and a metallic taste were the most frequent oral symptoms during hospitalization, with the incidence of 68.6%, 51.4%, 49.3%, 31.4%, and 29.3% in patients, respectively. Using tobacco significantly increased the incidence of xerostomia, dysgeusia, hypogeusia, halitosis, and a metallic taste during hospitalization (P = 0.011, P = 0.001, P = 0.002, P = 0.0001, and P = 0.0001, respectively). Smoking led to increasing dysgeusia, hypogeusia, halitosis, and a metallic taste during hospitalization (P = 0.019, P = 0.014, P = 0.013, and P = 0.006, respectively). The micro-average receiver operating characteristic (ROC) curve analysis revealed that the machine learning logistic regression model achieved the highest area under the ROC curve with a value of 0.83. Conclusions: Xerostomia and dysgeusia are the most common oral symptoms of COVID-19 patients and could be used to predict COVID-19 infection. Dysgeusia correlates with xerostomia, and it is hypothesized that xerostomia is an etiologic factor for dysgeusia. The early detection of COVID-19 can help reduce the enormous burden on healthcare systems, and machine learning is advantageous for this purpose.
Fast, but not so furious. On the distinctiveness of a fast life history strategy and the common core of aversive traits
Authors: Horsten Luisa K. , Hilbig Benjamin E. , Thielmann Isabel , Zettler Ingo , Moshagen Morten
Published: May 2022

Evolutionary Psychology has considered a Fast Life History Strategy (FLHS), denoting an individual’s tendency to invest more resources in proliferation than in child-rearing, to be responsible for the emergence of aversive traits. Empirical evidence for this notion has been inconsistent, however. Herein, we tested whether FLHS is an adequate representation of the underlying disposition of aversive traits (N = 869). To this end, we considered twelve specific aversive traits, and additionally measured and modeled the common core of these traits. We found only weak correlations of FLHS with individual aversive traits as well as with their common core. In sum, the results suggest that the common core of aversive traits is only marginally reflected in FLHS.
Z problematyki treści czynności konwencjonalnych w prawie
Authors: Gmerek Karolina
Published: May 2022

The purpose of the article is to accomplish several complementary research tasks. First, the issue of sources of the content of conventional acts in law is discussed. Then, detailed issues regarding the content of conventional acts in law are presented against the background of dogmatic and legal reflections as well as problems related to the identification of conventional acts. Additionally, the author makes an attempt to determine the ways of understanding ‘the content (of conventional acts in law)’ in particular legal sciences. The research results presented in the article (apart from their cognitive value) are supposed to serve the development of the general theoretical concept of conventional acts in law, as well as to organise the dogmatic and legal discussion on the titular issue as much as possible.
Wybrane zagadnienia dotyczące przetwarzania danych osobowych w procedurze rozstrzygania sporów zbiorowych
Authors: Szmit Jakub
Published: May 2022

The purpose of the article is analyse how essential the issue of personal data protection is in the procedure of leading a collective dispute. In order to make some findings in this matter, the dogmatic and legal method was primarily used and the provisions of the Act on Resolving Collective Disputes and the GDPR were analysed in the first place. The findings made lead to the conclusion that despite the fact that the dispute itself is collective, both parties (both the trade union and the employer) process a range of personal data during the dispute. Due to the specifics of the procedure and the fact that the Act was essentially created before the GDPR came into force and it was not amended for the inclusion of broadly understood requirements for the correctness of the processing of personal data, it is necessary to rely on general principles resulting from the GDPR, and a certain indicator of it may be opinions issued by the PDPO. The issue raised in this paper has so far been included in certain statements from the doctrine, but its practical significance and importance for social partners who execute their constitutional right to lead collective disputes fully justify further research in this direction as well as the fact of findings resulting from that research reaching various target groups (apart from the above-mentioned social partners, representatives of the judicature and science should also be reached).
Prawo do żywności z perspektywy Pierwszych narodów
Authors: Srogosz Tomasz
Published: May 2022

The purpose of the article is to propose a concept of the collective right to food which may turn out to be essential in fighting hunger and malnutrition on a global scale. International agreements, including Pacts on Human Rights, overlook the rights of indigenous peoples by corresponding to the individualistic, state-centric, consumeristic and commercial vision of the right to food. An approach, which is based on the objectives of critical studies on law, to the official dogma of the right to food (developed within expert and intergovernmental bodies in the form of the UN Committee on Economic, Social and Cultural Rights) allows for claiming that the dogma is less legitimized than the collective right to food (defined in the Decla-ration of Atitlán) resulting from the indigenous peoples’ practice. This is why, remaining in the sphere of the official, Grotian international legal order, it should be acknowledged that the indigenous peoples’ right to food defined in the article is a part of third-generation rights (next to the second-generation individualistic right to food) while remaining strictly connected to the right to self-determination and the right to development. It is a result of the long-term practice of those peoples. The above-mentioned proposal of the third-generation right to food has not been applied to the legal doctrine so far. Its value is the opportunity to develop and study the concept of food sovereignty that allows one to more effectively combat hunger and malnutrition on a global scale as compared to the previous actions of international communities.
Investigasi strategi desain ruang ramah tunarungu berbasis simulasi multisensori
Authors: Trisnawati Ersalina , Dewi Julia , Prakoso Susinety
Published: May 2022

Penelitian ini menggunakan metode simulasi analisis akustik dan visual untuk mengevaluasi kualitas ruang, serta memahami bagaimana desain ruang tertentu dapat menghadirkan kualitas multisensori yang dapat mendukung penyandang tunarungu. Simulasi analisis akustik menggunakan Ecotect untuk mengukur reverberasi dan pantulan suara. Sementara simulasi analisis visibilitas menggunakan depthmapX untuk mengukur isovist pengguna, integrasi, dan visibilitas ruang. Hasil simulasi menunjukkan bahwa ruang dengan sumber suara dari atas akan lebih baik dalam mendistribusi suara tanpa menimbulkan tingkat reverberasi ruang yang tinggi. Sumber suara berbentuk pocket dan organic enclosure dapat mengurangi tingkat reverberasi dan pantulan suara dalam ruang, meningkatkan privasi ruang sekaligus memberikan lapang pandang yang cukup luas bagi penglihatan kaum tunarungu. Hasil penelitian ini menemukan bahwa ada tiga konsep utama yang mempengaruhi kualitas akustik dan visual bagi kaum tunarungu, yaitu enclosure yang mempengaruhi tingkat privasi dan reverberasi ruang, integrasi yang menentukan visibilitas spasial dan orientasi massa atau bidang, serta material yang mempengaruhi kualitas absorpsi suara dalam ruang.

This study addressed the auditorial necessity and visual potential of the deaf using acoustic and visual analysis simulation. Due to the poorly designed room acoustics, the deaf people had difficulties communicating, despite the use of hearing aids or cochlear implants. This condition often causes some distorted sound waves in hearing aids. To compensate for the deficiency in auditory abilities, the deaf people relied on their peripheral vision as a source of information for communication. However, the understanding of parameters of room geometry that are necessary to support both the acoustic and visual qualities of the deaf was limited. Based on the depthmapX and Ecotect simulations, this study discovered that the source of the sound in space should come from the top to minimise the reverberation time. Spaces in the form of pockets and with organic enclosure also minimise the reverberation time and sound reflection, achieving privacy while maintaining the potential peripheral vision of the deaf. The study also revealed that a room with acoustic and visual qualities for the deaf should incorporate three concepts, i.e., an enclosure to achieve a certain level of privacy and sound reverberation; integration of spatial visibility following the room or wall orientations; and consideration of the use of materials to absorb the different frequencies of sound.
Resilience as an investigation of the relationship between architecture and nature
Authors: De Caro Valerio
Published: May 2022

Recent research involving the architectural project seems to have brought attention to natural elements and phenomena, highlighting particular interest in the interpretation of the dynamic processes of the environment and of all its entities, plant and natural that inhabit it. In a logic of resilience, which should lead to limiting the consumption of resources, the action of replacing technological devices with natural mechanisms tested throughout natural history appears to be a losing battle right from the start. Yet man, in the past, has shown that he is able to give interpretations of nature that are not limited to a mechanistic replacement of the natural process, but which are based on the representation and reformulation of organisms in relation to matter and space. Space understood as an architectural essence, which from the relationship with nature gives back meaningful forms and experiences. The analysis of a series of case studies starting from the Lascaux caves up to the contemporary reinterpretations by Anton-Garcia Abril and Terunobu Fujimori demonstrate how nature can be an element of inspiration for innovative research in the field of design without necessarily embarking on a drift technological.
(In)visible architecture: An exploration of food in the domestic space
Authors: Zayn Fatimah Indonesia Saffana , Atmodiwirjo Paramita
Published: May 2022

This paper investigates the notion of visibility and invisibility in architecture as a framework for exploring the existence of food in the domestic area. The paper argues that there is a disconnection between food, people, and the process behind it in everyday life. Such disconnection demonstrates the alternating visible and invisible existence of food process. Exploring both existences becomes essential to reveal the overall spatial story of food. The paper explores these two aspects through the food journey in the domestic space, creating a micro investigation of how food is obtained, prepared, cooked, and served. This paper aims to examine the possibilities of outlining the complex programming in everyday systems driven by the visibility and invisibility of food in domestic settings. Based on the findings of this study, the paper develops a form of programming titled (In)visible architecture, which constructs the co-existence between visible and invisible. Using exploration of tracing, mapping, and design mechanisms, such programming aims to reveal the complex visibility of everyday systems and, by doing so, broaden the relevance of knowledge of food-based architectural design.
A sensorial foray into architecture
Authors: Paramita Kristanti Dewi
Published: May 2022

Discussion of a sensory-driven architecture emphasises the need for a deeper and more holistic understanding of space. The collection of articles in this issue of ARSNET presents a variety of methods for engaging with the sensorial experience. These articles explore the process of measuring, interpreting, tracing, and constructing the spatial elements and spatial processes driven by sensorial stimulants, driving different projections of space. From the emergence of architecture that is more responsive to the diverse and subjective body needs in space to architecture that responds towards natural qualities as well as natural processes. Some articles also enable propositions of architectural form and programming with sensory-induced spatialities and temporalities. Through such projections, the issue creates multiple possibilities for sensory-driven design objectives which transcend contexts, practices and users, significantly expanding the sensory architecture discourse.
T cells discriminate between groups C1 and C2 HLA-C
Authors: Sim Malcolm J W , Stotz Zachary , Lu Jinghua , Brennan Paul , Long Eric O , Sun Peter D
Published: May 2022

Dimorphic amino acids at positions 77 and 80 delineate HLA-C allotypes into two groups, C1 and C2, which associate with disease through interactions with C1 and C2-specific natural killer cell receptors. How the C1/C2 dimorphism affects T cell recognition is unknown. Using HLA-C allotypes that differ only by the C1/C2-defining residues, we found that KRAS-G12D neoantigen-specific T cell receptors (TCRs) discriminated between C1 and C2 presenting the same KRAS-G12D peptides. Structural and functional experiments, and immunopeptidomics analysis revealed that Ser77 in C1 and Asn77 in C2 influence amino acid preference near the peptide C-terminus (pΩ), including the pΩ-1 position, in which C1 favors small and C2 prefers large residues. This resulted in weaker TCR affinity for KRAS-G12D-bound C2-HLA-C despite conserved TCR contacts. Thus, the C1/C2 dimorphism on its own impacts peptide presentation and HLA-C-restricted T cell responses, with implications in disease, including adoptive T cell therapy targeting KRAS-G12D-induced cancers.
An Adaptive and Greener Traffic Signal Coordination Scheme for Transport 4.0
Authors: Weerasundara W. A. G. , Udugahapattuwa D. P. D. , Munasingha T. D. , Gunathilake W. D. K. , Dampage Udaya
Published: May 2022

Traffic congestion has become a major concern, aroused as a result of increased population and urbanization. Hence, novel and innovative methods for controlling ever-increasing traffic volumes are essential. Conventional traffic light schemes are the most popular method of controlling traffic, and it is logical and economical to make research endeavors to optimize their existing performance. Despite numerous studies, the aforementioned problem has not been optimally and sufficiently solved. In this research, we introduce an adaptive traffic signaling scheme based on vehicle density to facilitate optimal traffic signal control as well as effective traffic management. We also propose effective coordination of the traffic amongst the junctions. Here, the live video is utilized as an input provided to a deep Q network to provide adaptive phase timings as the output. In the proposed scheme, we introduced per car unit (PCU) as a novel parameter to represent the effect of each vehicle type on traffic conditions. Numerous filed trials on real-time data amply prove that the proposed scheme enhances the average speed of traffic up to 5.597 km/h. The proposed scheme shows an average increment of 175.71% in average mean speed compared to the existing static schemes. Except for the high traffic scenario, for both mid traffic and low traffic scenarios, the proposed scheme shows a considerable improvement in both average densities and maximum densities. In the mid-traffic scenario, the average speed shows an improvement of 3.85 km/h, while in the low traffic scenario, the average mean speed shows an improvement of 7.96 km/h. A reduction in fuel consumption and average delay were also observed, which will lead to a greener Transport 4.0.
Newborn Screening-A Bolstering Step towards Quality Health in Neonates
Authors: Patel Suprava , Ritupriya . , Padhi Phalguni , Naik Tripty , Nanda Rachita , Mohapatra Eli , Agrawal Sarita
Published: May 2022

Introduction: Newborn Screening (NBS) is considered the need of the hour for quality health in neonates. It is also important to understand that the rising trend of prevalence of inherited metabolic disorders and the various maternal factors that might influence genetic changes in the foetus in- utero affecting the neonatal outcome. Aim: The primary objective of the study was to determine frequency of Congenital Hypothyroidism (CH) and Glucose- 6-Phosphate Dehydrogenase (G6PD) deficiency in a most approachable tertiary care hospital. The secondary objectives were to find out impact of maternal factors on the frequency of the disease and the impact of the disorder on the neonate’s health. Materials and Methods: The cross-sectional study was conducted on 1282 neonates of 48 hours upto eight weeks of age. The Dried Blood Spot (DBS) specimens collected were analysed for Thyroid Stimulating Hormone (TSH) level and G6PD enzyme activity. Details of neonatal characteristics and antenatal history were documented. Prevalence of CH and G6PD deficiency was calculated and maternal and neonatal variables were analysed for association using Statistical Package for the Social Sciences (SPSS) version 20. Results: The prevalence of CH and G6PD were respectively 3.3/1000 and 6.6/1000 making the overall prevalence of metabolic disorders as 9.8/1000. A 27.3% had Low Birth Weight (LBW) and 62% had low Ponderal Index (PI). The odds for raised TSH was 6.62 times in sick neonates. The probability for high TSH in LBW babies was more by 94% and in female neonates by 18%. The neonates with higher TSH values depicted significant association with maternal age (p=0.016), gestational age (p=0.019) and maternal anaemia (p<0.001). Babies born by caesarean section showed twice the chances for screening positive for TSH. Conclusion: The high prevalence estimated in this study and association with maternal factors urges new queries and recommends an obligatory need for NBS program in this region.
Effect of Mode of Delivery on Cord Blood Thyroid Stimulating Hormone Levels- A Cross-sectional Study
Authors: Gurnani Roshni , Engade Madhuri Bhagwan , Mohammed Haseeb , Sindhu Saranya Murlidharan , Goiporia Mahafrin Homar , choudhary Arti Subesingh
Published: May 2022

Introduction: Cord Blood Thyroid Stimulating Hormone (CBTSH) level estimation is an accepted screening tool for Congenital Hypothyroidism (CH). CBTSH levels are affected by many perinatal factors including mode of delivery. Previous studies have shown conflicting results on effect of mode of delivery of CBTSH levels. Aim: To study CBTSH profile in neonates born at tertiary care referral centre and to analyse the influence of mode of delivery (vaginal vs caesarean) on CBTSH levels. Materials and Methods: This was a cross-sectional study conducted at Mahatma Gandhi Medical College and Hospital from February 2014 to August 2015. Study population included 856 neonates (males=437, females=419). The CBTSH levels were estimated using Electrochemiluminescence Immunoassay ‘ECLIA’ on the Elecsys 2010 analyser. CBTSH levels between vaginally delivered and caesarean section born babies were compared. The values were tabulated as mean and statistically analysed using Statistical Package for the Social Sciences (SPSS) software version 21. Results: Mean CBTSH level of vaginally born neonates were 9.59 (median 7.0) in comparison to 9.11 (median 7.15) in caesarean born babies, this difference was not statistically significant. Conclusion: As per the present study finding mode of delivery did not have any significant effect on CBTSH levels.
Molecular Characterisation of Corynebacterium diphtheriae Isolates of Faucial Diphtheria Cases from Assam: A Cross-sectional Study
Authors: Choudhury Gargi , Gogoi Navonil , Nath Reema , Sargiary Pallabi , Das Partha Pratim , Bhuyan Binita , Borkotoki Uttara
Published: May 2022

Introduction: Diphtheria caused by toxigenic Corynebacterium diphtheriae is an acute respiratory infection characterised by pseudomembrane formation in the throat. Although diphtheria is often reported sporadically across India, molecular characterisation of C.diphtheriae strains could play a crucial role in epidemiological investigations. Aim: The present study aimed at molecular characterisation of Corynebacterium diphtheriae isolates of faucial diphtheria cases from Assam, North-East India utilising Multi-Locus Sequence Typing (MLST). Materials and Methods: In this cross-sectional study, three isolates were obtained from three different cluster of cases that occurred across two districts of Assam, India for a period from November 2019 to June 2020. MLST of these three C.diphtheriae isolates were performed in Multidisciplinary Research Unit of Assam Medical College and Hospital by using the 7-gene MLST alleles of C.diphtheriae to determine the Sequence Types (ST). Results: The MLST of the three isolates of this study revealed two distinct STs, ST-588 and ST-576 with multi-clonal lineages with ST-466, reported in C.diphtheriae strains of North Kerala and ST-301 related strains of Bangladesh respectively. Conclusion: In spite of frequent reports of diphtheria cases from Assam, molecular typing of the C.diphtheriae strains found in North-Eastern region of India has not yet been performed. This is one of the initial investigations from this region of India to use MLST for typing C.diphtheriae strains. Therefore, studies related to molecular characterisation of C.diphtheriae strains found throughout India could immensely help in determining the clonality and diversity existing among these strains.
A Case-control Study of Sexual Dysfunction and Serum Prolactin Levels in Patients with Psychotic Disorders
Authors: Alam Mohd Rashid , Rastogi Pali , Mathur Rahul , Niranjan Vijay
Published: May 2022

Introduction: Sexual functioning has remained widely neglected aspect of patient care for those suffering from severe mental disorders and has received little attention. Yet, it has been construed as one of the major factors contributing to nonadherence with antipsychotic medications. Aim: To study sexual dysfunction in patients with psychotic disorders and its clinical association with serum prolactin levels. Materials and Methods: This case-control study was conducted in the Department of Psychiatry at MGM Medical College and associated Mental Hospital, Indore, Madhya Pradesh, India, from 13th February 2020 to 21st January 2021. The study sample consisted of 200 subjects including 100 cases and 100 controls. The case group included patients with a diagnosis of psychotic disorders currently in remission for at least 1 month. Remission of the patients was ensured by Brief Psychiatric Rating Scale (BPRS) with a score of <4 on all items and <28 total score. Assessment of sexual dysfunction was done using Arizona Sexual Experience Scale (ASEX). The control group included healthy subjects aged between 18-65 years, either sex having active sexual partners with a score of < 3 on all the items of the General Health Questionnaire (GHQ-12). Collection of blood sample was done and serum was analyzed for prolactin levels using the Chemiluminescent Microparticle Immunoassay (CMIA) method. Statistical analysis was done using Statistical Package for the Social Sciences version 28.0 (SPSS) for windows. Results: The mean age of the case group was 39.9±7.457 years while that of the control group was 35.60±9.37 years. The number of male patients (71% and 73%) was higher than females (29% and 27%) in the control group and case group respectively. The difference between the two were statistically significant. The total number of cases who experienced sexual dysfunction came out to be 59 out of 100. Total 55.93% of those having sexual dysfunction were suffering from difficulty in sexual arousal, followed by difficulty with penile erection/vaginal lubrication (49.15%), orgasmic dysfunction (34.48%), and reduced sexual drive (23.72%). Among the cases, the mean serum prolactin level (14.14±10.60 ng/mL) was seen to be significantly higher (p-value <0.001) than the control group (9.46±6.05 ng/mL). Maximum serum prolactin level (29.00±9.95 ng/mL) was seen to be associated with usage of a combination of both 1st and 2nd generation antipsychotics. Conclusion: There was a significant prevalence of sexual dysfunction in psychotic patients and is associated significantly with elevated serum prolactin levels.
Constructing Flexible All‐Solid‐State Supercapacitors from 3D Nanosheets Active Bricks via 3D Manufacturing Technology: A Perspective Review
Authors: Li Bolin , Yu Mei , Li Zesheng , Yu Changlin , Wang Hongqiang , Li Qingyu
Published: May 2022

Due to the unique geometric characteristics and electronic structure of hierarchical 3D nanosheets, they show excellent electron migration rate, ultra‐high specific surface area, and reliable structural stability. Therefore, 3D nanosheets have great application prospects in the field of electrochemical energy storage. Supercapacitor has attracted extensive attention in recent years due to its merits of fast charge and discharge, long cycle life, safety, and stability. Flexibility, miniaturization, and intelligent integration are the development direction of supercapacitor energy storage devices. The emerging 3D printing technology, especially the ink direct writing mode, has greatly improved the design ability and control accuracy of device microstructures. Based on the research progress of 3D graphene nanosheets and 3D MXene nanosheets in the early stage of the authors’ or other teams, this paper proposes to use advanced 3D printing technology to realize the design of flexible all solid‐state supercapacitors by using 3D nanosheets active materials with high specific capacitance. The design methods of interdigital electrodes, multilayer skeleton electrodes and fiber electrodes by 3D printing technology and the performance evaluation of flexible supercapacitor are systematically analyzed. This perspective review aims to provide new conception and theoretical guidance for the design, preparation, and performance optimization of 3D nanosheets‐built materials by 3D printing for the practical application of flexible all‐solid‐state supercapacitor in the future.
Highly Efficient Sensitized Chiral Hybridized Local and Charge‐Transfer Emitter Circularly Polarized Electroluminescence
Authors: Kong Fan‐Cheng , Yang Sheng‐Yi , Liao Xiang‐Ji , Feng Zi‐Qi , Shen Wan‐Shan , Jiang Zuo‐Quan , Zhou Dong‐Ying , Zheng You‐Xuan , Liao Liang‐Sheng
Published: May 2022

This work describes the first hot exciton fluorescent material based on benzo[c][1,2,5]thiadiazole and chiral binaphthol enabling circularly polarized luminescence (CPL) through a chiral perturbation strategy. The new molecular architecture displays CPL, hybridized local and charge transfer (HLCT) properties concurrently. Utilizing it as the emitter, circularly polarized organic light‐emitting diodes (CP‐OLEDs) achieve an external quantum efficiency (EQE) of 7.2% with a good exciton utilization (36%) and a moderate circularly polarized electroluminescence (CPEL) dissymmetry factor (gEL, 2.1 × 10−3). In addition, the CP‐HLCT molecule is sensitized by a thermally activated delayed fluorescence material, significantly ameliorating the efficiency of HLCT fluorescent CP‐OLEDs. Excellent performances of twofold maximum EQE (EQEmax) of 15.3% and 82% exciton utilization are obtained in the sensitized device, regarding an extremely low‐efficiency roll‐off of 2.6% at 1000 cd m−2 as well as CPEL with a gEL value of 2.0 × 10−3.
Effectively Unlocking the Potential Molecular Room Temperature Phosphorescence of Pure Carbazole Derivatives
Authors: Yuan Shou , Zhang Yuefa , Chen Junwu , Yu Yuan , Yue Lingtai , Sun Qikun , Zhang Haichang , Xue Shanfeng , Yang Wenjun
Published: May 2022

The current prevailing views are that carbazole derivatives without isomers show inferior room temperature phosphorescence (RTP) and that N‐aryl carbazole derivatives exhibit no ultralong RTP in dilute film states since the distorted structures easily dissipate the excitation energy. In the current work, we present that doping N‐aryl carbazole derivatives with heteroatoms and/or heavy halogen into PMMA at the molecular level by thermoplasticizing solution‐cast films can achieve ultra‐long‐lived (>1 s) and highly‐efficient (>36%) molecular RTP without the need of crystallization and isomer doping. Unlike isomer‐doped crystals that almost all emit yellow RTP, the RTP colors of doped PMMA films depend on the molecular structures of carbazole derivatives. Also, we can realize highly efficient and long‐lived red fluorescence afterglow via persistent Förster resonance energy transfer from RTP emission to fluorescent emitter. These colorful afterglow polymer films exhibit an ultra‐long (>20 h) photo‐activation pattern memory effect. This work has challenged existing experimental results and relative RTP mechanisms, providing a reasonable processing strategy for manifesting and enhancing the deserved RTP properties of organic doped polymers.
Functionalized Macrophage Exosomes with Panobinostat and PPM1D‐siRNA for Diffuse Intrinsic Pontine Gliomas Therapy
Authors: Shan Shaobo , Chen Junge , Sun Yu , Wang Yongchao , Xia Bozhang , Tan Hong , Pan Changcun , Gu Guocan , Zhong Jie , Qing Guangchao , Zhang Yuxuan , Wang Jinjin , Wang Yufei , Wang Yi , Zuo Pengcheng , Xu Cheng , Li Fangzhou , Guo Weisheng , Xu Lijun , Chen Meiwan , Fan Yubo , Zhang Liwei , Liang Xing‐Jie
Published: May 2022

Diffuse intrinsic pontine glioma (DIPG) is a rare and fatal pediatric brain tumor. Mutation of p53‐induced protein phosphatase 1 (PPM1D) in DIPG cells promotes tumor cell proliferation, and inhibition of PPM1D expression in DIPG cells with PPM1D mutation effectively reduces the proliferation activity of tumor cells. Panobinostat effectively kills DIPG tumor cells, but its systemic toxicity and low blood–brain barrier (BBB) permeability limits its application. In this paper, a nano drug delivery system based on functionalized macrophage exosomes with panobinostat and PPM1D‐siRNA for targeted therapy of DIPG with PPM1D mutation is prepared. The nano drug delivery system has higher drug delivery efficiency and better therapeutic effect than free drugs. In vivo and in vitro experimental results show that the nano drug delivery system can deliver panobinostat and siRNA across the BBB and achieve a targeted killing effect of DIPG tumor cells, resulting in the prolonged survival of orthotopic DIPG mice. This study provides new ideas for the delivery of small molecule drugs and gene drugs for DIPG therapy.