bluuebunny/crossref_metadata_2025 huggingface dataset:
Sentinel Node Necrosis Is a Negative Prognostic Factor in Patients with Nasopharyngeal Carcinoma: A Magnetic Resonance Imaging Study of 252 Patients
Authors: Lu L. , Wei X. , Li Y. H. , Li Wenbin
Published: June 2017

Purpose: We explored the patterns of sentinel node metastasis and investigated the prognostic value of sentinel node necrosis (SNN) in patients with nasopharyngeal carcinoma (NPC), based on magnetic resonance imaging (MRI). Methods: This retrospective study enrolled 252 patients at our institution who had metastatic lymph nodes from biopsy-confirmed NPC and who were treated with definitive radiation therapy, with or without chemotherapy. All participants underwent MRI before treatment, and the resulting images were reviewed to evaluate lymph node status. The patients were divided into SNN and non-SNN groups. Overall survival (OS), tumour-free survival (TFS), regional relapse–free survival (RRFS), and distant metastasis–free survival (DMFS) were calculated by the Kaplan–Meier method, and differences were compared using the log-rank test. Factors predictive of outcome were determined by univariate and multivariate analysis. Results: Of the 252 patients, 189 (75%) had retropharyngeal lymph node metastasis, and 189 (75%) had level IIA or IIB lymph node necrosis. The incidence of snn was 43.4% (91 of 210 patients with lymph node metastasis or necrosis, or both). After a median follow-up of 54 months, the 5-year rates of OS, TFS, RRFS, and DMFS in the SNN and non-SNN groups were, respectively, 79.4% and 95.3%, 73.5% and 93.3%, 80.4% and 96.6%, and 75.5% and 95.3% (all p < 0.01). Age greater than 40 years, SNN, T stage, and N stage were significant independent negative prognostic factors for OS, TFS, RRFS, and DMFS. Conclusions: Metastatic retropharyngeal lymph nodes and necrotic level II nodes both seem to act as sentinels. Sentinel node necrosis is an negative prognostic factor in patients with NPC. Patients with snn have a worse prognosis.
Development and Pre-Testing of a Rehabilitation Planning Consultation for Head-and-Neck Cancer
Authors: McEwen Sara , Dunphy C. , Rios J. Norman , Davis A. , Jones J. , Lam A. , Poon I. , Martino R. , Ringash J.
Published: June 2017

Background: In contrast with other major chronic conditions such as heart disease and stroke, cancer care does not routinely integrate evidence-based rehabilitation services within the standard continuum. The objectives of the present project were to develop a rehabilitation planning consultation (RPC) for survivors of head-and-neck (HN) cancer, to test its feasibility, and to make refinements. Methods: Using intervention mapping, the RPC-alpha was developed by examining potential theoretical methods and practical applications relative to the program objectives. During feasibility testing, a single case series was conducted with survivors of HN cancer who had completed their cancer treatment within the preceding 11 months; iterative refinements were made after each case. Results: The RPC-alpha was led by a rehabilitation professional and was based on self-management principles. The initial consultation included instruction in a global cognitive strategy, goal-setting, introduction to available resources, action planning, and coping planning. A follow-up consultation was conducted a few weeks later. Of 9 participants recruited, 5 completed post-intervention assessments. Participants reported that the rpc helped them to make rehabilitation plans. Conclusions: The rpc was feasible to use and satisfactory to a small group of hn cancer survivors. A pilot test of the refined version is in process.
Interventions to Address Sexual Problems in People with Cancer
Authors: Barbera Lisa , Zwaal C. , Elterman D. , McPherson K. , Wolfman W. , Katz A. , Matthew A.
Published: June 2017

Background: Sexual dysfunction in people with cancer is a significant problem. The present clinical practice guideline makes recommendations to improve sexual function in people with cancer. Methods: This guideline was undertaken by the Interventions to Address Sexual Problems in People with Cancer Expert Panel, a group organized by the Program in Evidence-Based Care (PEBC). Consistent with the PEBC standardized approach, a systematic search was conducted for existing guidelines, and the literature in MEDLINE and EMBASE for the years 2003–2015 was systematically searched for both systematic reviews and primary literature. Evidence found for men and for women was evaluated separately, and no restrictions were placed on cancer type or study design. Content and methodology experts performed an internal review of the resulting draft recommendations, which was followed by an external review by targeted experts and intended users. Results: The search identified 4 existing guidelines, 13 systematic reviews, and 103 studies with relevance to the topic. The present guideline provides one overarching recommendation concerning the discussion of sexual health and dysfunction, which is aimed at all people with cancer. Eleven additional recommendations made separately for men and women deal with issues such as sexual response, body image, intimacy and relationships, overall sexual functioning and satisfaction, and vasomotor and genital symptoms. Conclusions: To our knowledge this clinical practice guideline is the first to comprehensively evaluate interventions for the improvement of sexual problems in people with cancer. The guideline will be a valuable resource to support practitioners and clinics in addressing sexuality in cancer survivors.
Total synthesis of elansolids B1 and B2
Authors: Wang Liang-Liang , Kirschning Andreas
Published: June 2017

The elansolids A1–A3, B1, and B2 are secondary metabolites formed by the gliding bacterium Chitinophaga sancti. They show antibacterial activity against Gram-positive bacteria. A second generation total synthesis of the antibiotic elansolid B1 (2) and the first synthesis of elansolid B2 (3) are reported. In contrast to previous work, the (Z,E,Z)-triene at C10–C15 was assembled by using an optimized C–C cross-coupling sequence with a Suzuki cross-coupling reaction as key step.
The Rest-frame Optical (900 nm) Galaxy Luminosity Function at z ∼ 4–7: Abundance Matching Points to Limited Evolution in the MSTAR/MHALO Ratio at z ≥ 4
Authors: Stefanon Mauro , Bouwens Rychard J. , Labbé Ivo , Muzzin Adam , Marchesini Danilo , Oesch Pascal , Gonzalez Valentino
Published: June 2017

We present the first determination of the galaxy luminosity function (LF) at z ∼ 4, 5, 6, and 7, in the rest-frame optical at

(z′ band). The rest-frame optical light traces the content in low-mass evolved stars (∼stellar mass—M
*), minimizing potential measurement biases for M
*. Moreover, it is less affected by nebular line emission contamination and dust attenuation, is independent of stellar population models, and can be probed up to z ∼ 8 through Spitzer/IRAC. Our analysis leverages the unique full-depth Spitzer/IRAC 3.6–8.0 μm data over the CANDELS/GOODS-N, CANDELS/GOODS-S, and COSMOS/UltraVISTA fields. We find that, at absolute magnitudes where

is fainter than

mag,

linearly correlates with

. At brighter

,

presents a turnover, suggesting that the stellar mass-to-light ratio

could be characterized by a very broad range of values at high stellar masses. Median-stacking analyses recover an

roughly independent on

for

mag, but exponentially increasing at brighter magnitudes. We find that the evolution of the LF marginally prefers a pure luminosity evolution over a pure density evolution, with the characteristic luminosity decreasing by a factor of

between z ∼ 4 and z ∼ 7. Direct application of the recovered

generates stellar mass functions consistent with average measurements from the literature. Measurements of the stellar-to-halo mass ratio at fixed cumulative number density show that it is roughly constant with redshift for

. This is also supported by the fact that the evolution of the LF at

can be accounted for by a rigid displacement in luminosity, corresponding to the evolution of the halo mass from abundance matching.
Relation between the Variations in the Mg ii λ2798 Emission Line and 3000 Å Continuum
Authors: Zhu Dongchun , Sun Mouyuan , Wang Tinggui
Published: June 2017

We investigate the relationship between the

emission line and the 3000 Å continuum variations using a sample of 68 intermediate-redshift (

) broad-line quasars spanning a bolometric luminosity range of 44.49 erg

erg s−1 (Eddington ratio from ∼0.026 to 0.862). This sample is constructed from SDSS-DR7Q and BOSS-DR12Q, each with at least two spectroscopic epochs in SDSS-I/II/III surveys. In addition, we adopt the following signal-to-noise ratio (S/N) selection criteria: (a) for

and the 3000 Å continuum, S/N

10; and (b) for narrow lines, S/N

5. All our quasar spectra are recalibrated based on the assumption of constant narrow emission-line fluxes. In an analysis of spectrum-to-spectrum variations, we find a fairly close correlation (Spearman

) between the variations in broad

and in the continuum. This is consistent with the idea that

is varying in response to the continuum emission variations. Adopting the modified weighted least squares regression method, we statistically constrain the slopes (i.e., the responsivity α of the broad

) between the variations in both components for the sources in different luminosity bins after eliminating intrinsic biases introduced by the rescaling process itself. It is shown that the responsivity is quite small (average

) and anti-correlates with the quasar luminosity. Our results indicate that high signal-to-noise flux measurements are required to robustly detect the intrinsic variability and the time lag of the

line.
The Remarkable Similarity of Massive Galaxy Clusters from z ∼ 0 to z ∼ 1.9
Authors: McDonald M. , Allen S. W. , Bayliss M. , Benson B. A. , Bleem L. E. , Brodwin M. , Bulbul E. , Carlstrom J. E. , Forman W. R. , Hlavacek-Larrondo J. , Garmire G. P. , Gaspari M. , Gladders M. D. , Mantz A. B. , Murray S. S.
Published: June 2017

We present the results of a Chandra X-ray survey of the eight most massive galaxy clusters at z > 1.2 in the South Pole Telescope 2500 deg2 survey. We combine this sample with previously published Chandra observations of 49 massive X-ray-selected clusters at 0 < z < 0.1 and 90 Sunyaev–Zel’dovich–selected clusters at 0.25 < z < 1.2 to constrain the evolution of the intracluster medium (ICM) over the past ∼10 Gyr. We find that the bulk of the ICM has evolved self-similarly over the full redshift range probed here, with the ICM density at

scaling like

. In the centers of clusters (

), we find significant deviations from self-similarity (

), consistent with no redshift dependence. When we isolate clusters with overdense cores (i.e., cool cores), we find that the average overdensity profile has not evolved with redshift—that is, cool cores have not changed in size, density, or total mass over the past ∼9–10 Gyr. We show that the evolving “cuspiness” of clusters in the X-ray, reported by several previous studies, can be understood in the context of a cool core with fixed properties embedded in a self-similarly evolving cluster. We find no measurable evolution in the X-ray morphology of massive clusters, seemingly in tension with the rapidly rising (with redshift) rate of major mergers predicted by cosmological simulations. We show that these two results can be brought into agreement if we assume that the relaxation time after a merger is proportional to the crossing time, since the latter is proportional to

.
Haptoglobin phenotypes and susceptibility of Schistosoma parasites infection in central Sudan
Authors: Yousif Ashraf Siddig , Elagib Atif Abdelrahman
Published: June 2017

Haptoglobin (Hp) is an acute phase protein that binds the free haemoglobin (Hb), thus preventing iron loss and renal damage. Hp also has anti-oxidative and immunomodulatory properties. Three Hp phenotypes have been identified in human: Hp1-1, Hp2-1 and Hp2-2. Hp polymorphisms have been related to susceptibility of various diseases. In this study we aimed to assess the possible association of Hp phenotypes polymorphism to Schistosoma parasites infection in central Sudan. We have investigated the Hp phenotypes polymorphism distribution in the serum of 125 (93 S. mansonai, 13 S. haematobium and 19 infected with both ‘’co-infection’’) parasitologically confirmed infected individuals and 208 healthy individuals served as control. Hp phenotypes have been determined by polyacrylamide gel electrophoresis followed by benzidine staining. Our study revealed that Hp1-1 percentage frequency was significantly higher in infected individuals than healthy control individuals 51% and 26% respectively. Our data suggest that Hp1-1 phenotype may upsurge the susceptibility to Schistosoma parasites infection in central Sudan.
Domain Modeling and Application Development of an Archetype- and XML-based EHRS
Authors: Kropf Stefan , Chalopin Claire , Lindner Dirk , Denecke Kerstin
Published: June 2017

Background: Access to patient data within the hospital or between hospitals is still problematic since a variety of information systems is in use applying different vendor specific terminologies and underlying knowledge models. Beyond, the development of electronic health record systems (EHRSs) is time and resource consuming. Thus, there is a substantial need for a development strategy of standardized EHRSs. We are applying a reuse-oriented process model and demonstrate its feasibility and realization on a practical medical use case, which is an EHRS holding all relevant data arising in the context of treatment of tumors of the sella region. In this paper, we describe the development process and our practical experiences.

Methods: Requirements towards the development of the EHRS were collected by interviews with a neurosurgeon and patient data analysis. For modelling of patient data, we selected openEHR as standard and exploited the software tools provided by the openEHR foundation. The patient information model forms the core of the development process, which comprises the EHR generation and the implementation of an EHRS architecture. Moreover, a reuse-oriented process model from the business domain was adapted to the development of the EHRS.

Results: The reuse-oriented process model is a model for a suitable abstraction of both, modeling and development of an EHR centralized EHRS. The information modeling process resulted in 18 archetypes that were aggregated in a template and built the boilerplate of the model driven development. The EHRs and the EHRS were developed by openEHR and W3C standards, tightly supported by well-established XML techniques. The GUI of the final EHRS integrates and visualizes information from various examinations, medical reports, findings and laboratory test results.

Conclusion: We conclude that the development of a standardized overarching EHR and an EHRS is feasible using openEHR and W3C standards, enabling a high degree of semantic interoperability. The standardized representation visualizes data and can in this way support the decision process of clinicians.

Citation: Kropf S, Chalopin C, Lindner D, Denecke K. Domain modeling and application development of an archetype- and XML-based EHRS: Practical experiences and lessons learnt. Appl Clin Inform 2017; 8: 660–679 https://doi.org/10.4338/ACI-2017-01-RA-0009
Superovulation and expression of follicle-stimulating hormone receptor in young rabbit females
Authors: Zhang Hao , Cheng Guo Hu , Li Yong Jun , Cai Miao Yin , Guo Hai Yan , Qin Kang Le
Published: June 2017

To optimise the use of juvenile in vitro embryo transfer technologies in young rabbit females, superovulation was performed in New Zealand White young rabbit females at different ages and the expression mode of follicle-stimulating hormone receptor (FSHR) was explored using real-time quantitative polymerase chain reaction, and in vitro maturation (IVM) together with fertilisation (IVF) was conducted immediately after superovulation. The results showed that (1) the age factor significantly affected superovulation in young rabbit females, with 60 d as an optimal age; (2) the mRNA level of FSHR exhibited a rising trend, though it was lower at 30 to 40 d of age; (3) the maturation rate of the oocytes from 60 d old rabbits was significantly higher than in those from 50 d old rabbits; (4) the fertilisation rate of oocytes was not significantly different among rabbits 50, 60 and 70 d old.
Effect of competitive exclusion in rabbits using an autochthonous probiotic
Authors: Cunha Sara , Mendes Ângelo , Rego Dinis , Meireles Diana , Fernandes Ruben , Carvalho André , Costa Paulo Martins da
Published: June 2017

Animal nutrition has been severely challenged by the ban on antimicrobials as growth promoters. This has fostered the study of alternative methods to avoid colonisation by pathogenic bacteria as well as to improve the growth of animals and feed conversion efficiency. These new options should not alter the normal intestinal microbiota, or affect it as little as possible. The use of probiotics, which are live microorganisms that beneficially affect the host by improving its intestinal microbial balance, can be seen as a promising way to achieve that goal. In this study, New Zealand White rabbits were fed diets containing an autochthonous probiotic of Enterococcus spp., with the strains EaI, EfaI and EfaD, and Escherichia coli, with the strains ECI 1, ECI 2 and ECD, during a 25-d trial, to evaluate the impact of the probiotic on the faecal microbiota, including population dynamics and antimicrobial resistance profiles. A control group of rabbits, which was fed a diet containing a commonly used mixture of antimicrobials (colistin, oxytetracycline, and valnemulin), was also studied. To assess the colonisation ability of the mentioned probiotic, the faecal microbiota of the rabbits was characterised up to 10 d after the administration had ended. Isolates of enterococci and E. coli were studied for phylogenetic relationships using enterobacterial repetitive intergenic consensus (ERIC-PCR) and pulse-field gel electrophoresis (PFGE), respectively. Although partially affected by an unexpected clinical impairment suffered by the rabbits in the experimental group, our results showed the following. The difference between the growth rate of the animals treated with antimicrobials and those fed the probiotic was not statistically significant (P> 0.05). The competitive exclusion product was present in the faecal samples in a large proportion, but stopped being recovered by culture as soon as the administration ended and the housing conditions were changed. Multidrug-resistant strains of enterococci and E. coli were more commonly recovered from faecal samples of animals fed diets containing antimicrobials, than from rabbits fed diets with our probiotic formula. The use of E. coli probiotics to prevent infection by enteropathogenic strains must be carefully considered due to the possible occurrence of gastrointestinal signs. On the other hand, enterococci strains may be more effective, but lack the long-term colonisation ability.
Progressive Multifocal Leukoencephalopathy Associated with Infliximab
Authors: Sammut L , Wallis D , Holroyd C
Published: June 2017

A 69-year-old female with seropositive rheumatoid arthritis presented with progressive cognitive decline following treatment with infliximab and methotrexate. Cranial MRI showed non-enhancing white matter signal abnormality consistent with demyelination was seen in the antero-inferior left frontal lobe extending into the frontal opercular white matter and into the left temporal lobe white matter. Similar appearances were seen in the inferomedial right frontal lobe. Brain biopsy showed histological changes consistent with progressive multifocal leukoencephalopathy. The cerebrospinal fluid polymerase chain reaction was negative but brain tissue polymerase chain reaction was positive for JC virus. This case highlights the association of infliximab with progressive multifocal leukoencephalopathy in a patient with known seropositive rheumatoid arthritis.
Penicillin: Promise, Problems and Practice in Wartime Edinburgh
Authors: Gardiner S
Published: June 2017

While medical historians have paid ample attention to the introduction of antibiotics and their impact on hospital-based practice during and after the Second World War, the multiple issues surrounding their use in Scottish hospitals are sorely lacking in current discussions. Drawing on an extensive yet underused range of materials including patient treatment records, oral histories and medical correspondence, this paper explores the introduction of penicillin for civilian treatment at the Royal Infirmary of Edinburgh during the closing stages of the War. It highlights the success of the drug in clinical treatment as well as its shortcomings, offering an alternative view of its initial impact on surgical practice.
Stroke Prevention in Atrial Fibrillation
Authors: Voukalis C , Shantsila E , Lip GYH
Published: June 2017

Oral anticoagulation therapy has reduced the risk of ischaemic stroke and improved the outcomes for patients with atrial fibrillation considerably. The emergence of the non-vitamin K oral anticoagulants as alternatives to vitamin K antagonists has significantly changed the practice of stroke prevention in atrial fibrillation. As the main complication with antithrombotic therapy is bleeding, physicians should always balance the risk of ischaemic stroke against intracranial haemorrhage and intervene where appropriate to reduce both risks. Individual approach is often mandatory due to heterogeneity of the risks and patient preferences. The purpose of this review is to summarise the current knowledge of the oral anticoagulation therapy in atrial fibrillation patients and guide physicians with the management of anticoagulants based on data from clinical trials and systematic reviews.
Do Not Attempt Cardiopulmonary Resuscitation Decisions: Joint Guidance
Authors: Campbell R
Published: June 2017

Since its introduction in the 1960s as a treatment to restart the heart after sudden cardiac arrest from a heart attack, attempts at cardiopulmonary resuscitation have become more common in other clinical situations. Cardiopulmonary resuscitation can be a lifesaving treatment, with the likelihood of recovery varying greatly depending on individual circumstances; however, overall, the proportion of people who survive following cardiopulmonary resuscitation is relatively low. Anticipatory decisions were recognised as being the best way of ensuring that cardiopulmonary resuscitation was not attempted against individuals’ wishes.

Since 2001, the British Medical Association, Resuscitation Council (UK) and Royal College of Nursing have published professional guidance on decisions relating to cardiopulmonary resuscitation. The latest version of this guidance was published in June 2016. This paper summarises the key legal and ethical principles that should inform all cardiopulmonary resuscitation decisions, with particular emphasis on the recent changes in law and policy.
Improved model for correcting the ionospheric impact on bending angle in radio occultation measurements
Authors: Angling Matthew J. , Elvidge Sean , Healy Sean B.
Published: June 2017

Abstract. The standard approach to remove the effects of the ionosphere from neutral atmosphere GPS radio occultation measurements is to estimate a corrected bending angle from a combination of the L1 and L2 bending angles. This approach is known to result in systematic errors and an extension has been proposed to the standard ionospheric correction that is dependent on the squared L1/L2 bending angle difference and a scaling term (κ). The variation of κ with height, time, season, location and solar activity (i.e. the f10.7 flux) has been investigated by applying a 1D bending angle operator to electron density profiles provided by a monthly median ionospheric climatology model. As expected, the residual bending angle is well correlated (negatively) with the vertical TEC. However, κ is more strongly dependent on the solar zenith angle. Furthermore, over the height range of interest (40–80 km) κ is approximately linear with height. A simple κ model has also been developed. It is independent of ionospheric measurements, but incorporates geophysical dependencies (i.e. solar zenith angle, solar flux, altitude). The global mean error (i.e. bias) and the standard deviation of the residual errors are reduced to −2.2 × 10−10 rad and 2.0 × 10−9 rad respectively. Although a fixed scalar κ also reduces bias for the global average the selected value of κ (14 rad−1) is only appropriate for a small band of locations around the solar terminator. In the day time, the scalar κ is consistently too high and this results in an over correction of the bending angles and a positive bending angle bias. Similarly, in the night time, the scalar κ is too low. However, in this case, the bending angles are already small and the impact of the choice of κ is less pronounced.
From a Student of Startup Business to a Startup Employee or Entrepreneur: Study on Career Narratives of Students in Entrepreneurial Programs in a University
Authors: Saukkonen Juha
Published: June 2017

The purpose of this research is to gain an understanding of the incidents, relationships and processes that support entrepreneurial students to become employees and entrepreneurs. Through a qualitative approach based on career history and projections written by the respondents, this study aims to shed light on the process of becoming an entrepreneur or employed by an entrepreneurial organization. Pedagogical and professional issues that may foster the development of these practices eventually leading to employment and entrepreneurial activities are posed.
Stress-Strain Relationship and Seismic Performance of Cast-in-Situ Phosphogypsum
Authors: Zhang Yichao , Dai Shaobin , Weng Wanlin , Huang Jun , Su Ying , Cai Yue
Published: June 2017

Background

Phosphogypsum is a waste by-product during the production of phosphoric acid. It not only occupies landfill, but also pollutes the environment, which becomes an important factor restricting the sustainable development of the phosphate fertilizer industry. Research into cast-in-situ phosphogypsum will greatly promote the comprehensive utilization of stored phosphogypsum. The aim of this study was to clarify the mechanical properties of phosphogypsum.

Methods

Stress-strain relationships of cast-in-situ phosphogypsum were investigated through axial compressive experiments, and seismic performance of cast-in-situ phosphogypsum walls and aerated-concrete masonry walls were simulated based on the experimental results and using finite element analysis.

Results

The results showed that the stress-strain relationship fitted into a polynomial equation. Moreover, the displacement ductility index and the energy dissipation index of cast-in-situ phosphogypsum wall were 6.587 and 3.425, respectively.

Conclusions

The stress-strain relationship for earthquake-resistant performance of cast-in-situ phosphogypsum walls is better than that of aerated-concrete masonry walls. The curve of stress-strain relationship and the evaluation of earthquake-resistant performance provide theoretical support for the application of cast-in-situ phosphogypsum in building walls.
Percepções das gestantes e puérperas sobre a saúde bucal infantil: influência das condições sociodemográficas
Authors: Massoni Andreza Cristina de Lima Targino , Pereira Rosaney Barbosa , Fernandes Jocianelle Maria Felix de Alencar , Dantas Lydiane Dos Santos , Perazzo Matheus De França , Granville-Garcia Ana Flávia
Published: June 2017

Objetivo: verificar a associação entre as condições sociodemográficas e a percepção de gestantes e puérperas
sobre a saúde bucal dos seus filhos. Sujeitos e método: estudo transversal, censitário, realizado com
100 gestantes e puérperas, atendidas em Maternidade pública de referência no Nordeste do Brasil. Os dados
foram coletados por meio de entrevista. A análise dos dados envolveu estatística descritiva e inferencial, através
do teste Qui-Quadrado (α=0,05). Resultado: observou-se, das investigadas, considerável conhecimento
sobre a saúde bucal na infância. E, considerando as variáveis sociodemográficas, a escolaridade das mães
apresentou associação com a questão relacionada ao momento para início dos cuidados bucais (p=0,03).
No que diz respeito à renda familiar, foi encontrada associação dessa com as questões relacionadas à higiene
dos dentes antes da erupção dentária (p=0,03) e ao momento para início dos cuidados bucais (p=0,04).
A principal dúvida das mães em relação ao tema, foi sobre a adequada forma de higienização bucal das
crianças (40,6%). Como sugestão para terem acesso a informações, essas propuseram principalmente a realização
de palestras na sala de espera dos serviços de assistência médico-hospitalar (23,0%). Conclusão: as
mães apresentaram um considerável domínio do tema. Em relação aos dados sociodemográficos, a escolaridade
materna foi associada ao início dos cuidados bucais dos filhos, enquanto a renda foi associada à higiene dos
dentes antes da erupção dentária e ao momento para início dos cuidados bucais.
Higienização bucal em pacientes com deformidades nas mãos: uso de adaptador para escova dental
Authors: Quaggio Cristina Maria da Paz , Nogueira Maira Giampietro de Almeida , Sgavioli Claudia De Almeida Prado Piccino , Marafiotti Graziela De Almeida Prado Piccino , Franzolin Solange De Oliveira Braga , Virmond Marcos Da Cunha Lopes
Published: June 2017

Objetivo: avaliar o efeito do uso de uma adaptação para escova dental em indivíduos afetados pela hanseníase com garra e avaliar sua contribuição na higiene bucal. Sujeitos e método: estudo realizado no Instituto Lauro de Souza Lima, com amostra de dez pacientes com idade
acima de 18 anos, apresentando garra ulnar, ou garra ulnar mediano no membro dominante, entre 2013 e 2016. Foram realizadas a identificação dos pacientes, de seu perfil social e da forma clínica da hanseníase e
a análise da higienização bucal pelo Índice de Higiene Oral Simplificado (IHO-S). Cada componente desse índice é avaliado em uma escala de 0 a 3. O resultado do IHO-S é dado pela média dos pontos de cada dente,
assim classificados: 0 a 1 – higiene satisfatória; 1,1 a 2 – higiene regular; 2,1 a 3 – higiene deficiente. Resultados: o IHO-S dos pacientes foi medido em três momentos: antes da entrega do adaptador; uma semana de uso contínuo do adaptador, 15 dias de uso contínuo do
adaptador. Observaram-se valores menores da média e mediana do IHO-S com o uso do adaptador, de acordo com o tempo. O teste estatístico ANOVA confirmou a diferença significativa entre os grupos (p = 0,002196). O teste Tukey registrou a diferença do 1o momento em
relação ao 2o (p = 0,02509) e ao 3o (p = 0,002199); não houve diferença estatística significativa entre o 2o e o 3o momentos. O teste de Kruskal-Wallis confirmou a diferença significativa entre os grupos (p = 0,005887). Conclusões: a tecnologia assistiva pode gerar melhora
na capacidade funcional. Mesmo considerando o pequeno universo deste estudo, conclui-se que as adaptações podem contribuir para a melhora da qualidade de vida e também para a melhor qualidade da higiene
bucal de tal população.
Research on the Reform of the Preliminary Course of Architectural Design Based on Innovation & Practice Ability Training
Authors: Yuping Cai , Shuang Liang
Published: June 2017

The traditional undergraduate education mode of architecture has been unable to adapt to the rapid development of society. Taking the junior professional course of architecture—the preliminary course of architectural design as an example, this paper analyzes the problems existing in the current professional courses of lower grades, puts forward the opinion that the cultivation of innovation & practice ability should be included in the professional training objectives, and the corresponding reforms of the training program and teaching methods should be made, in order to provide the reference for the construction in the basic teaching of architecture.
The influence of Helicobacter pylori eradication therapy on the presence of H. pylori antigens in dental plaque and saliva
Authors: Namiot DB. , Leszczyńska K. , Namiot A. , Kemona A. , Bucki R. , Chilewicz M. , Namiot Z
Published: June 2017

Purpose: The aim of this study was to evaluate the presence of H. pylori antigens in the oral cavity (dental plaque and saliva) of patients undergoing systemic eradication therapy. Materials and methods: The study was conducted in 49 subjects with H. pylori stomach infection. H. pylori antigens in dental plaque and saliva were evaluated with immunological method. Results: In subjects with initial H. pylori oral infection, the presence of H. pylori antigens in the oral cavity 6 weeks after successful or unsuccessful H. pylori eradication therapy in the stomach was 47.0% and 50.0%, respectively. In subjects without initial oral infection with H. pylori, the presence of H. pylori antigens in the oral cavity 6 weeks after successful and unsuccessful eradication therapy in the stomach was 30.0% and 20.0%, respectively. Conclusions: The immunological method detecting H. pylori antigens in the dental plaque and saliva cannot be recommended to evaluate the efficacy of H. pylori eradication in the oral cavity.
Exclusion from service consumption in Polish health care system
Authors: Holecki T. , Wróblewski M. , Woźniak-Holecka J. , Sobczyk K.
Published: June 2017

Purpose: The scientific objective of this research was to determine social groups affected by exclusion in Polish health care. Materials and methods: Survey was carried out among local government units and nongovernmental organizations by using authorial questionnaire distributed towards representative research group selected. Results: This work depicts activities of social welfare centers in cooperation with non-profit sector entities, in the field of exclusion from the access to health care benefits in Poland, appointing circumstances, causes and the range of this exclusion. It presents the results of the countrywide research in the context of structure and tasks of the health care, but also two points of view (institutional and social one) for resolving the same population issues. Conclusions: On the basis of the conducted analyses it has been stated that social exclusion, in the field of health care, is a significant social problem, but the biggest difficulty is the access to the rehabilitation benefits and pharmacological therapy
Clinical usefulness of MMP-2 and TIMP-2 concentrations in the preoperative serum of patients with colorectal cancer
Authors: Pryczynicz A. , Gryko M. , Dymicka-Piekarska V. , Lewczuk Ł , Wakulewska A. , Ozimkiewicz M. , Lebelt A. , Guzińska-Ustymowicz K.
Published: June 2017

Purpose: To evaluate the clinical significance of MMP-2 and TIMP-2 concentrations in the sera of patients diagnosed with colorectal cancer. Methods: The study group comprised 48 patients with colorectal carcinoma and 24 healthy controls. The serum concentration of MMP-2 and TIMP-2 proteins was evaluated by the ELISA method. Results: The mean level of MMP-2 in the sera of patients with colorectal cancer was 39.4 ng/ml and was significantly lower compared with the control (p<0.001). A decrease in TIMP-2 protein in the sera of patients with colorectal cancer was also observed where its mean level was 132.3 ng/ml. The concentration of MMP-2 and TIMP-2 did not correlated with any clinicopathological parameters, except for the patients’ age. In addition, the concentration of MMP-2 in the sera of patients with CRC correlated negatively with the number of white blood cells in the blood and the prothrombin index. The concentration of TIMP-2 correlated positively with potassium and urea concentration in the blood. Conclusions: The results of our study indicate lack of clinical usefulness of determining the levels of MMP-2 and TIMP-2 in the sera of patients with colorectal cancer. However, these proteins play an important role in the carcinogenesis of colorectal cancer.
IGF-I and IGF-binding proteins in synovial fluid of patients with Lyme arthritis
Authors: Bączyk J. , Guszczyn T. , Romanowicz L. , Pancewicz Sł. , Moniuszko A. , Popko J.
Published: June 2017

Purpose: Multiple cellular functions are stimulated by a Insulin-like Growth Factor-I (IGF-I). The biological activity of IGF-I is modulated by IGFbinding proteins (IGF-BPs) and at the same time, the availability of IGF-BPs may be regulated by the proteolytic activity of some metalloproteinases (MMPs). The aim of the present study was to compare the amounts of IGF-I and IGF-BPs in relation to the activity of MMP-9 in serum and knee synovial fluid from patients with Lyme arthritis (LA) and post-traumatic damage (PTD). Material and methods: Serum and synovial fluids were taken from knee joints of patients with PTD and LA. ELISA (for IGF-I assay), polyacrylamine gel electrophoresis following Western immuneblotting (for IGF-I and IGF-BPs expression), and zymography (for metalloproteinases detection), were used. Results: The concentration of IGF-I in serum and synovial fluid from LA patients were significantly lowered in comparison to PTD patients. Interesting, the synovial fluid /serum ratio of IGF-I concentrations was also lower in LA patients. Low expression IGF-BP3 and high activity of MMP-9 were detected in the LA synovial fluid. Conclusions: The high proteolytic activity of MMP- 9 results in a cleavage of both IGF-I and IGF-BP3 causing a decrease in content of these substances in LA synovial fluid. In addition, the reduction in IGF and IGF-BP amounts may affect the repair processes in joint tissues of LA patients. The low concentration of IGF-I and IGF-BP3 slows down the repair processes in the joint tissues of LA patients.
Immersion Coefficient for the Marine Optical Buoy (MOBY) Radiance Collectors
Authors: Feinholz Michael , Johnson B Carol , Voss Kenneth , Yarbrough Mark , Flora Stephanie
Published: June 2017

The immersion coefficient accounts for the difference in responsivity for a radiometer placed in the air versus water or another medium. In this study, the immersion coefficients for the radiance collectors on the Marine Optical Buoy (MOBY) were modeled and measured. The experiment showed that the immersion coefficient for the MOBY radiance collectors agreed with a simple model using only the index of refraction for water and fused silica. With the results of this experiment, we estimate that the uncertainty in the current value of the immersion coefficient used in the MOBY project is 0.05 % (k = 1).
Short Report: A Pilot Study of a Group Positive Psychology Intervention for Patients with Multiple Sclerosis
Authors: Leclaire Kaitlynne , Cecil Audrey , LaRussa Allison , Stuart Fiona , Hemond Christopher C. , Healy Brian C. , Chitnis Tanuja , Weiner Howard , Huffman Jeff , Glanz Bonnie I.
Published: June 2017

Background:

Positive psychology uses targeted activities to increase the frequency and intensity of positive emotional experiences. Positive psychology interventions that increase positive constructs may facilitate adjustment and improve well-being in patients with multiple sclerosis (MS). The primary goal of this study was to assess the feasibility and acceptability of a 5-week group positive psychology intervention for patients with MS. In addition, we examined the utility of the group intervention to increase positive psychological constructs and health-related quality of life (HRQOL).

Methods:

11 patients completed 5 weeks of group positive psychology training, one time per week (session duration, 45–60 minutes). Each week, patients completed one of the following positive psychology exercises: gratitude for positive events, personal strengths, gratitude letter, enjoyable and meaningful activities, and remembering past successes. Patients completed patient-reported outcome measures, including measures of positive affect, optimism, depression, anxiety, and HRQOL, at baseline and after 5 weeks.

Results:

All the participants completed the 5-week group positive psychology intervention, and 82% attended four or more sessions. Improvements in fatigue (vitality) and depression after the group intervention were significant (P = .016 and .049, respectively). There were no statistically significant changes in positive or negative affect, optimism, anxiety, HRQOL, or cognition.

Conclusions:

The 5-week group positive psychology intervention was feasible and acceptable to patients with MS. A randomized controlled trial is necessary to further explore the effectiveness of the group intervention.
ANIPA 2016 activity
Authors: Vassalli Andrea
Published: June 2017

Not available.
Normas face ao género e à diversidade sexual: mudanças inacabadas nos discursos juvenis
Authors: Neves Dulce Morgado
Published: June 2017

Assuming that young people have more tolerant and individualistic standards than the previous generations, this paper uses excerpts from biographical interviews applied to boys and girls to question the limits of the sexual liberalization ideology. To do that, the analysis focuses on two key dimensions of the discourses on changes in sexuality: the gender equality and the acceptance of sexual diversity. Without denying the growing flexibility of affective and sexual norms and trajectories, we seek to show that the experience of sexuality reflects a movement towards the liberalization of the conducts only in the prescribed limits, being such constraints attached to the gender differences and to the heteronormativity.
Interview: Interview with Arlie Russell Hochschild by Madalena D’Oliveira-Martins
Authors: D’Oliveira-Martins Madalena
Published: June 2017

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Nova governação pública e meritocracia
Authors: Bilhim João Abreu de Faria
Published: June 2017

The aim of this paper is to clarify, in administration and public policy, the concept of new public governance, distinguishing it from other approaches. The literature search performed on the “state of the art”, it is concluded that the scientific studies of governance are associated with the separation of supply and production units of public services and a new form of relationship between the state and the rest of society (Aligica and Tacko, 2012). On the other hand, the scientific studies of governance are also associated with the efficiency of cooperation networks between social and institutional actors (Tavares and Mamede, 2011) in that the state no longer plays the only and not the main role which set the research agenda.
RODAS DE LEITURA: O PROFESSOR EM FORMAÇÃO INICIAL E A EXPERIÊNCIA DA MEDIAÇÃO EM SALA DE AULA
Authors: Rasia Gesualda De Lourdes dos Santos , Cruz Franciele da
Published: June 2017

Este estudo contempla relato e reflexão acerca de experiência de Rodas de Leitura implementada por bolsistas de Iniciação à Docência (ID) do Programa Institucional de Bolsas de Iniciação à Docência (PIBID) da Universidade Federal do Paraná (UFPR) junto à Escola Estadual de 1. Grau Manoel Ribas (Curitiba- PR), no ano de 2014), por alunos da Universidade. As Rodas consistem em programa de incentivo à leitura, criado em Curitiba, pelo Programa Curitiba Lê, o qual engloba outras ações, todas com a finalidade maior de formação de leitores. Essa prática tem como um de seus principais vetores o acolhimento das diferentes leituras de participantes da comunidade em geral, não necessariamente com história de leitura consolidada. O deslocamento, para o contexto escolar, produziu o diferencial da continuidade, na medida em que esteve dirigida a um mesmo público, variável esta que possibilitou aos bolsistas mensurarem o processo da formação de leitores no intervalo de um ano e, sobretudo, refletir acerca do modo como os sentidos foram se estabelecendo. Como sustentação da prática metodológica, lançou-se mão de referenciais teóricos assinados por Eliana Yunnes, precursora das Rodas de Leitura, e de Eni Orlandi, teórica que trouxe a Análise do Discurso de orientação francesa para o Brasil, teoria esta que discute, centralmente, aspectos relacionados à interpretação
A IDENTIDADE E A FORMAÇÃO DO PROFESSOR DE PORTUGUÊS: QUESTÕES DE LINGUAGEM, PERCEPÇÃO DE ENSINO E LETRAMENTO DIGITAL
Authors: Silva Júnior Silvio Nunes da
Published: June 2017

O ensino de Português no Brasil é alvo de diversas discussões sobre como e porque devemos ensinar a língua materna e quais os segmentos que os documentos oficiais e as principais linhas teóricas apresentam para essa prática. Isso remete-nos a refletir acerca da formação docente, sobre as formas de pensar a prática em sala de aula e, sobretudo, a construção da identidade do profissional perante a tantas inovações que a educação reverencia. Diante disso, o presente trabalho vem refletir as questões de identidade linguística e social do professor de português na contemporaneidade. Abrangemos na fundamentação teórica reflexões sobre o ensino de português no Brasil, a formação do professor de português, as questões de identidade em linguística aplicada e a procedência metodológica através de uma narrativa autobiográfica, considerando para a análise os seguintes aspectos: a linguagem, a percepção de ensino e o letramento digital. Foi possível constatar que a concepção de linguagem adotada pela professora está direcionada às correntes normativista e sociolinguística; a percepção de ensino é fundamentada nas representações sociais da prática profissional; e a aquisição do letramento digital se emprega em pontos como a formação docente e o investimento governamental em educação e tecnologia.
Seismic characteristics of supershear and sub‐Rayleigh earthquakes: Implication from simple cases
Authors: Zhang Zhenguo , Xu Jiankuan , Huang Hanqing , Chen Xiaofei
Published: June 2017

Numerous investigations of supershear earthquakes make a conclusion that a supershear earthquake produces a seismic shock wave on the ground that may increase the resulting destruction. We investigate a supershear rupture promoted by the free surface and find out that although the seismic energy of a supershear earthquake can be transmitted further with large amplitudes, the peak slip velocity on a fault near the free surface is smaller than that caused by a subshear rupture earthquake. Our results show that the free‐surface‐induced supershear rupture mitigates the amplitudes of ground motions near the fault plane compared with the subshear rupture. The Coulomb failure change derived from dynamic modeling further suggests that this free‐surface‐induced supershear reduces aftershock potential compared to a subshear rupture. Both ground motion at near‐fault and aftershock possibility show low risk for the free‐surface‐induced supershear rupture earthquake than subshear earthquake, contrary to the traditional concept.
New methodology for computing tsunami generation by subaerial landslides: Application to the 2015 Tyndall Glacier landslide, Alaska
Authors: George D. L. , Iverson R. M. , Cannon C. M.
Published: June 2017

Landslide‐generated tsunamis pose significant hazards and involve complex, multiphase physics that are challenging to model. We present a new methodology in which our depth‐averaged two‐phase model D‐Claw is used to seamlessly simulate all stages of landslide dynamics as well as tsunami generation, propagation, and inundation. Because the model describes the evolution of solid and fluid volume fractions, it treats both landslides and tsunamis as special cases of a more general class of phenomena. Therefore, the landslide and tsunami can be efficiently simulated as a single‐layer continuum with evolving solid‐grain concentrations, and with wave generation via direct longitudinal momentum transfer—a dominant physical mechanism that has not been previously addressed in this manner. To test our methodology, we used D‐Claw to model a large subaerial landslide and resulting tsunami that occurred on 17 October 2015, in Taan Fjord near the terminus of Tyndall Glacier, Alaska. Modeled shoreline inundation patterns compare well with those observed in satellite imagery.