Association of Mortality and Risk of Epilepsy With Type of Acute Symptomatic Seizure After Ischemic Stroke and an Updated Prognostic Model
Authors: Sinka Lucia , Abraira Laura , Imbach Lukas L. , Zieglgänsberger Dominik , Santamarina Estevo , Álvarez-Sabín José , Ferreira-Atuesta Carolina , Katan Mira , Scherrer Natalie , Bicciato Giulio , Terziev Robert , Simmen Cyril , Schubert Kai Michael , Elshahabi Adham , Baumann Christian R. , Döhler Nico , Erdélyi-Canavese Barbara , Felbecker Ansgar , Siebel Philip , Winklehner Michael , von Oertzen Tim J. , Wagner Judith N. , Gigli Gian Luigi , Serafini Anna , Nilo Annacarmen , Janes Francesco , Merlino Giovanni , Valente Mariarosaria , Zafra-Sierra María Paula , Bayona-Ortiz Hernan , Conrad Julian , Evers Stefan , Lochner Piergiorgio , Roell Frauke , Brigo Francesco , Bentes Carla , Peralta Ana Rita , Pinho e Melo Teresa , Keezer Mark R. , Duncan John S. , Sander Josemir W. , Tettenborn Barbara , Koepp Matthias J. , Galovic Marian 
Published: April 2023

Importance

Acute symptomatic seizures occurring within 7 days after ischemic stroke may be associated with an increased mortality and risk of epilepsy. It is unknown whether the type of acute symptomatic seizure influences this risk.

Objective

To compare mortality and risk of epilepsy following different types of acute symptomatic seizures.

Design, Setting, and Participants

This cohort study analyzed data acquired from 2002 to 2019 from 9 tertiary referral centers. The derivation cohort included adults from 7 cohorts and 2 case-control studies with neuroimaging-confirmed ischemic stroke and without a history of seizures. Replication in 3 separate cohorts included adults with acute symptomatic status epilepticus after neuroimaging-confirmed ischemic stroke. The final data analysis was performed in July 2022.

Exposures

Type of acute symptomatic seizure.

Main Outcomes and Measures

All-cause mortality and epilepsy (at least 1 unprovoked seizure presenting &amp;gt;7 days after stroke).

Results

A total of 4552 adults were included in the derivation cohort (2547 male participants [56%]; 2005 female [44%]; median age, 73 years [IQR, 62-81]). Acute symptomatic seizures occurred in 226 individuals (5%), of whom 8 (0.2%) presented with status epilepticus. In patients with acute symptomatic status epilepticus, 10-year mortality was 79% compared with 30% in those with short acute symptomatic seizures and 11% in those without seizures. The 10-year risk of epilepsy in stroke survivors with acute symptomatic status epilepticus was 81%, compared with 40% in survivors with short acute symptomatic seizures and 13% in survivors without seizures. In a replication cohort of 39 individuals with acute symptomatic status epilepticus after ischemic stroke (24 female; median age, 78 years), the 10-year risk of mortality and epilepsy was 76% and 88%, respectively. We updated a previously described prognostic model (SeLECT 2.0) with the type of acute symptomatic seizures as a covariate. SeLECT 2.0 successfully captured cases at high risk of poststroke epilepsy.

Conclusions and Relevance

In this study, individuals with stroke and acute symptomatic seizures presenting as status epilepticus had a higher mortality and risk of epilepsy compared with those with short acute symptomatic seizures or no seizures. The SeLECT 2.0 prognostic model adequately reflected the risk of epilepsy in high-risk cases and may inform decisions on the continuation of antiseizure medication treatment and the methods and frequency of follow-up.