bluuebunny/crossref_metadata_2025 huggingface dataset:
Public Perceptions Can Guide Regulation of Public Facial Recognition
Authors: Kugler Matthew
Published: January 2024

Facial recognition technology is changing how people pass through customs at airports, check in at schools, and move anonymously in public spaces. Yet despite these transformations, its use by the government is largely unregulated. This Article informs the policy and doctrinal debates about facial recognition by presenting a public attitudes perspective. These three novel empirical studies show the nuanced views that Americans hold about government use of facial recognition. The data reveal that people are generally comfortable with the government using facial recognition to investigate serious crimes, enhance the security of controlled spaces like airports and schools, and increase the efficiency of identity verification in some contexts. But people are often not comfortable with casual governmental facial recognition use in public spaces. This pattern of strong comfort for tailored uses persisted even when, in a second study, participants were primed with negative information about the accuracy of facial recognition. Here I explore the implications of these results for both current Fourth Amendment doctrine as well as future legislative reform, promoting a balanced approach that allows tailored use of facial recognition while regulating its purposes.
THE PLACE OF GPEC IN THE EMOTIONAL COMMITMENT OF PUBLIC EMPLOYEES
Authors: GUEDI Abdallah ADEN
Published: January 2024

The poor reputation and inefficiency of Djibouti's civil service employees is leading to a rethinking of their management systems and to a growing concern for the commitment of their human resources. So, for the past few years, public management has been trying to evolve under the impulse of many reforms such as the forward-looking management of jobs and skills, but the problem that arises is to know how the system of assignment based on the forward-looking management of jobs and skills could impact the affective commitment of the employees of the public service? Based on the hypothesis that the objectivity of assignments accentuates the affective commitment of civil servants, statistical processing of data from an opinion survey of a sample of 200 employees in twenty Djiboutian public establishments aims to analyse the impact of the JPCM on the affective commitment of public employees.ax
BERRY AND GRAPE METABOLITES FOR ANTIMICROBIAL APPLICATIONS AGAINST FOODBORNE BACTERIAL PATHOGENS
Authors: Cojocari Daniela , Ghendov-Mosanu Aliona , Sturza Rodica
Published: January 2024

The increase in the resistance of microorganisms to chemical substances and conventional drugs presents a serious and obvious problem worldwide, which has determined numerous researches aimed at the identification of new biocides with extended activity. Plants and their derivatives contain a wide variety of secondary metabolites that can inhibit or slow down the growth of bacteria, yeasts and molds. The microbiostatic activity of some berries represents a promising source of alternative solutions for their use in order to reduce the microbial contamination of raw materials and food products. The article elucidates the in vitro microbiostatic and microbicidal effects of some berries and grape marc rich in phenolic compounds with microorganisms that cause food spoilage: Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae. The composition of the extracts is examined, and possible mechanisms of antimicrobial action are analyzed.
OECD Chemicals Testing Regulation: validity for toxicological studies
Authors: Ponamarev V. S.
Published: January 2024

In order to validate the methods used to determine the toxicity of drugs, researchers usually turn to the most authoritative scientific literature, the system of state standards, or alternative systems. One of them is the OECD (Organization for Economic Co-operation and Development) regulations on testing chemicals. The article provides a brief analysis of the OECD regulations for testing chemicals (in particular, Chapter 2 “Effects on Biotic Systems” and Chapter 4 “Effects on Health”), which is a set of internationally recognized specifications for testing chemicals approved by the Organization for Economic Co-operation and development. The basic principles of conducting an experiment, the requirements for biological models for research, and the general system for assessing a particular type of toxicity were assessed. The main benefit of applying the OECD regulation in the context of toxicological studies is that it ensures uniformity of approaches and methodology in assessing chemical safety at the international level. This facilitates the comparison of research results, as well as the exchange of information between countries and organizations. Data quality control and adherence to GLP principles also provide confidence in research results, which is the basis for decision-making in chemical regulation and the protection of human, animal and environmental health. In general, OECD regulations in the context of toxicological research play an important role in ensuring safety and protecting public health and the environment. It provides standards and recommendations that facilitate the effective assessment of chemical safety and the development of appropriate measures to ensure it.
Hygienic assessment of the influence of the drugs «Kemitsid Plus» and «Kemisept» on the physiological parameters of broiler chickens during aerosol disinfection
Authors: Egorov A. A. , Lisovichenko V. A. , Belopolsky A. E.
Published: January 2024

In the system of sanitary, anti-epidemic and anti-epizootic measures that ensure the well-being of the country in terms of infectious diseases, increasing animal productivity and the sanitary quality of products, raw materials and feed of animal origin, disinfection occupies one of the important places. Disinfection is understood as the destruction of objects or the removal from them of pathogenic and conditionally pathogenic microorganisms. The main purpose of disinfection is to break the epizootic chain by influencing its important link - the factor of transmission of the pathogen from the source of infection to the susceptible organism. Given the variety of existing disinfectants and their constituent components, preparations with high bacterio- and virusstatic activity are very limited, which does not allow effective disinfection of contaminated surfaces, especially those contaminated with organic substances. The problem of introducing new highly effective disinfectants has become particularly relevant in connection with the spread of highly pathogenic microorganisms throughout the country.
Determination of the amount of microplastic found in Osmerus eperlanus caught in the Neva river
Authors: Dotsenko T. Yu. , Salova M. S.
Published: January 2024

This study draws attention to the current problem of pollution of aquatic ecosystems with microplastics and its potential impact on humans through food products. The level of microplastics in smelt Osmerus eperlanus, caught from the Neva River in St. Petersburg, was assessed. The research methodology included collecting fish samples and examining their internal organs and muscle fibers for the presence of microplastics. The results showed that microplastic particles were present in all samples examined, especially in female smelt. The study also found the presence of microplastics in the muscles of the fish, indicating the possibility of their entry into the human body through fish consumption.
Dynamics of some biochemical indicators of blood and indicators of growth activity in quail under the influence of feed additives
Authors: Nikitina A. A.
Published: January 2024

The work examines the results obtained when feeding feed additives to quail. A preparation containing the bacteria Bacillus subtilis was used as a feed additive for the birds of the first experimental group; feed yeast was introduced into the diet of the experimental group; all birds received supplements starting from the first day of life. In the control group, the birds were given only the basic diet, represented by an industrial combined feed for quail, in accordance with their age. Control weighing of birds in the experimental and control groups was carried out on the 28th, 42nd and 56th days. Blood was also obtained from the axillary vein for its biochemical study. As a result of the work, it was determined that when feed additives were introduced into the diet of quails, growth and development indicators increased, namely, in the first 42 days of the experiment, there was an increase in the growth rate in the first experimental group of birds by 60.2%, in the second experimental group by 56.8 , while the growth rate of quails in the control group from the first day of the experiment was 55%. By the 56th day of the experiment, the growth of the birds had slowed down significantly and no significant differences in the dynamics of this indicator were observed. During a biochemical study of blood obtained on the 56th day of the experiment, it was determined that the experimental birds had higher concentrations of total protein, an increase in ALT activity and a decrease in AST activity.
Studying the relationship of liver transaminases and alkaline phosphatase with the activity of gammaglutamyltransferase in horses
Authors: Vasileva S. V.
Published: January 2024

This article presents the results of a comparison of the activity of indicator enzymes of the hepatobiliary system in horses - alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) with the activity of gamma-glutamyltransferase (GGT). The results of a biochemical blood test were grouped according to the activity of gamma-glutamyltransferase and, in connection with this, 4 groups were formed with an enzyme activity step of 10 IU/l. When conducting a correlation analysis, a strong positive relationship was revealed between the level of GGT and AST (r = 0.97) and ALP (r = 0.88), and when comparing GGT and ALT, a moderate positive relationship was found (r = 0.64). The absence of natural changes in ALT activity with increasing GGT is explained by the induction of the enzyme to ensure the optimal rate of transamination in metabolic reactions, and not a consequence of liver pathology. A statistically significant increase in AST and ALP activity was found in the group with GGT activity exceeding standard limits, compared with the minimum values by 59.1% and 29.7%, respectively (P<0.05). An increase in GGT activity above the upper limit of the reference limits is accompanied by a significant increase in aspartate aminotransferase and alkaline phosphatase levels, which indicates the presence of pathology of the hepatobiliary system involving both the liver parenchyma and the biliary tract.
Morphological features of the structure of the taste budden in the African claria catfish
Authors: Grinyuk E. S. , Mkrtchyan M. E.
Published: January 2024

The taste organs have a species-specific structure in different animal species. The development of the taste bud in different species of fish occurs at different periods of ontogenesis. The purpose of our work was to study the morphological features of the structure of the taste bud in Clarias gariepinus. Analysis of our studies made it possible to determine the histological features of the structure of the mucous membrane of the esophageal wall. The taste bud is an important structure in the digestive system of the African clary catfish. It is round in shape and consists of specialized cells that have a number of features, each of which has a specific function. In the region of the taste pore at the apical pole, neurosensory cells are equipped with cilia, through which the signal is transmitted to the afferent nerve fiber. The data obtained can be used to study the microstructure of Clarias gariepinus organs, as well as to determine taste preferences, which will allow optimizing the operation of enterprises producing feed and therapeutic and prophylactic drugs for these fish species.
Assessment of the state of protein metabolism in highly productive cows with alimentary osteodistrophy
Authors: Karpenko L. Yu. , Bakhta A. A. , Ivanova K. P.
Published: January 2024

Alimentary osteodystrophy occurs as a result of an unbalanced diet, which leads to a violation of metabolic processes, one of which is protein metabolism. The purpose of this study was to analyze the main indicators of protein metabolism, such as total protein, α - globulins, β - globulins, γ - globulins, as well as to determine the concentration of glycoproteins and sialic acids in highly productive cows with alimentary osteodystrophy. The research was carried out on the basis of a livestock complex in the Leningrad region and at the Department of Biochemistry and Physiology of the FSUE HE "SPbGUVM". To conduct the experiment, two groups of animals were formed using the method of pairs of analogues. The first control group consisted of clinically healthy animals in the amount of 15 heads. In the second - experimental group, animals with alimentary osteodystrophy in the amount of 15 heads. Blood was taken from cows from the tail vein into vacuum tubes. Before taking blood, clinical examination and thermometry of animals were performed.When analyzing the data obtained, a tendency was revealed to decrease the concentration of total protein in the group of sick animals, there was a decrease in albumins (significantly lower (p<0.05) by 1.8 times) compared with the group of healthy cows, as well as a significant increase in the blood content of alpha-globulins in the blood of sick cows by 2.4 times compared with healthy ones. The content of glycoproteins in sick animals was 1.8 times higher (p<0.05) than in healthy animals, the index of sialic acids was 3.4 times higher than in healthy cows (p<0.05). Thus, in the course of research, it was revealed that the state of alimentary osteodystrophy is accompanied by changes in the concentrations of indicators characterizing the protein metabolism of animals. Thus, highly productive cows diagnosed with alimentary osteodystrophy are characterized by an increase in the blood of the α-globulin fraction of proteins, which includes proteins of the acute and chronic stages of inflammation, as well as glycoproteins and sialic acids, which are a marker of the degree of destructive processes in connective and cartilage tissue.
Erythrocyte indices changes analysis in dogs with sensitive digestion
Authors: Karpenko L. Yu. , Bakhta A. A. , Pogodaeva P. S. , Bokhan P. D.
Published: January 2024

According to the literature, sensitive digestion in dogs is quite common. About 25% of visits to veterinary clinics are related to diseases of the gastrointestinal tract. Sensitive digestion is a feature of the gastrointestinal tract associated with the body’s intolerance to any substances. As a rule, this condition is accompanied by disruption of enzymatic processes in the gastrointestinal tract, deterioration of absorption in the intestine and diarrhea. A clinical blood test allows you to evaluate the number and morphology of red blood cells, the concentration of hemoglobin in the blood, the hematocrit value and a number of red blood cell indices that reflect the physical characteristics of red blood cells. With a comprehensive assessment, these indicators give an idea of the presence or absence of anemia and dehydration, and also allow one to assess the degree of their severity. Changes in red blood levels during sensitive digestion are usually explained by a lack of vitamins and microelements, which develops as a result of decreased digestibility of food, as well as losses of fluid and nutrients as a result of diarrhea. In this article, red blood parameters in a group of dogs with sensitive digestion are assessed using standard hematological testing techniques to obtain baseline data and compare these indicators with the results that will be obtained after correcting the condition of the gastrointestinal tract with specially designed therapeutic diets.
Right coronary artery of the Eurasian lynx
Authors: Khvatov V. A. , Shchipakin M. V.
Published: January 2024

The Eurasian lynx is widely popular among wild feline animals. It is often the object of domestication and it is bred on fur farms for the extraction of fur products. Heart vascularization in domestic and wild mammalian animals has not been studied enough and is still an urgent area of research, our goal was to study the anatomy of the left coronary artery of the Eurasian lynx heart and establish its anatomical and topographic patterns. To study the anatomy of the heart, the corpses of the Eurasian lynx were taken at the age of two or three years. In total, five corpses of the Eurasian lynx were examined. Cadaver material was delivered from private fur farms of the Leningrad and Moscow regions to the Department of Animal Anatomy of the St. Petersburg State University of Veterinary Medicine. To study the vascularization of the heart of the studied animals, classical and modern anatomical techniques were carried out, such as fine anatomical dissection and the manufacture of corrosive preparations using latex. According to the results of the study, it was found that the left coronary artery in the Eurasian lynx is sufficiently developed and supplies blood to the structures of the left and right half of the heart, and the subsinuous artery does not belong to the branches of the left coronary artery, in connection with which it can be concluded that the uniform type of blood supply in the Eurasian lynx. The results of the study can be used by veterinary specialists, in particular surgeons, to establish operative access to the heart in the form of a pattern of branching of the left coronary artery of the heart in the Eurasian lynx.
Results of testing the protocol for cryopreservation of bull sperm using a concentrated dilutent medium
Authors: Korochkina E. A. , Pushkina V. S. , Bakhturina E. I. , Maksimova M. A. , Nikitin V. V.
Published: January 2024

In recent years, dairy farming has been actively developing in Russia in many directions, providing consumers with milk, dairy products, meat and other raw materials. Particularly relevant are the automation of the processes of raising cattle and the selection of the most economically profitable dairy and meat breeds, which is facilitated by the development of artificial insemination in this agricultural sector. The success of artificial insemination is determined by many factors, including the quality of sperm extenders used and the correctness of cryopreservation protocols. The purpose of this study is to test a protocol for cryopreservation of Holstein bull sperm. The ejaculate was collected, evaluated, and pre-prepared (centrifugation, dilution, cooling). The freezing process was carried out using the method presented in the article by AnsariM.S., RakhaB. A. et al. (2015) for buffalo sperm: the straws were kept above liquid nitrogen vapor at a distance of 5 cm for 10 minutes, and then immersed in a Dewar flask. Sperm motility was assessed 3 times: after sperm collection, after cooling, and 0 hours after thawing. The negative impact of the cryopreservation process on the morphofunctional characteristics of sperm was determined. The study noted a decrease in the motility of progressively moving sperm by 21.53%, as well as a sharp increase in immobile sperm before and after cryopreservation from 6.8% to 33.82%. The number of nonprogressive spermatozoa was reduced from 9.12% to 2.91%. Changes in the morphological parameters of sperm as a result of cryopreservation (after cooling and 0 hours after thawing): the number of normal sperm decreased by 12%, the number of sperm with tail defects increased by 11% and head by 2%. Based on the data obtained, we can conclude that the use of this cryopreservation protocol, with preliminary preparation, helps preserve sperm viability. Further research will be aimed at studying and creating cryoprotectors that increase the safety of sperm of breeding bulls during deep freezing.
PENGARUH UMUR PANEN TERHADAP KANDUNGAN PROTEIN KASAR, SERAT KASAR, DAN PRODUKSI PROTEIN KASAR HIJAUAN PAKAN FODDER JAGUNG YANG DIBERI AIR CUCIAN BERAS SEBAGAI HARA UTAMA
Authors: Septian Mohamad Haris
Published: January 2024

Penelitian ini bertujuan untuk mengetahui pengaruh umur panen yang berbeda terhadap kandungan protein kasar, serat kasar, dan produksi protein kasar hijauan pakan fodder jagung yang diberi air cucian beras sebagai hara utama. Penelitian ini dilaksanakan pada bulan Juni sampai Agustus 2022 di Greenhouse, Fakultas Pertanian, Universitas Tidar. Metode yang digunakan dalam penelitian ini adalah Rancangan Acak Lengkap (RAL) dengan 3 perlakuan dan 6 kali ulangan. Perlakuan terdiri dari umur panen 7 hari (P1), 14 hari (P2), dan 21 hari (P3). Data yang diperoleh dianalisis menggunakan analisis sidik ragam (ANOVA) dilanjutkan dengan Uji Duncanâ€™s Multiple Range Test dan Uji Polinomial Ortogonal menggunakan alat bantu IBM SPSS 26. Berdasarkan Uji DMRT menunjukkan bahwa kandungan protein kasar, serat kasar, dan produksi protein kasar tertinggi diperoleh pada umur panen 21 hari. Berdasarkan Uji Polinomial Ortogonal diperoleh persamaan y = -0,0363x2 + 1,4224x + 1,935 pada PK; y = -0.0709x2 + 2,7416x - 9,7775 pada SK; dan y = -0.0709x2 + 2,7416x - 9,7775 pada produksi PK.
RIZIK ENERGETSKOG SIROMAŠTVA IZ PERSPEKTIVE SOCIJALNIH PRAVA I SOCIJALNE POLITIKE
Authors: Pandžić Asim
Published: January 2024

Rad ima za cilj da ukaže na pojavu novog socijalnog rizika „energetsko siromaštvo“, analizirajući ga sa socijalnog aspekta iz perspektive socijalnih prava i socijalne politike. Ključno istraživačko pitanje koje se analizira u radu je kako ostvariti društvo jednakih mogućnosti u kojem „niko ne smije biti zapostavljen” pa tako i energetski zapostavljen i isključen, osiguravajući pristup dostupnoj, pouzdanoj, održivoj i modernoj energiji za sve iz perspektive socijalnih prava i pravedne raspodjele resursa i sve veće nemogućnosti jednog značajnog dijela stanovništva da obezbijedi osnovne energetske usluge. Rad analizira pitanje energetskog siromaštva sa socijalnog aspekta korištenjem metode – analiza sadržaja, te se u radu dovode u vezu pojmovi energije, održivog razvoja, socijalnih prava i socijalne politike. U kontekstu principa evropskog stupa socijalnih prava, pristup energetskim uslugama je ključan za socijalnu uključenost, a odgovarajuće grijanje, hlađenje, rasvjeta i energija za napajanje uređaja osnovne su usluge na kojima se temelji pristojan životni standard i zdravlje ljudi, što ujedno predstavlja i jedan od ciljeva održivog razvoja sadržanih u Agendi 2030. Međutim, usljed nemogućnosti zadovoljavanja osnovnih energetskih usluga, dolazi do pojave energetskog siromaštva. Negativni efekti energetskog siromaštva posebno se očituju u ranjivim društvenim grupama, a njegove posljedice su višestruke i bez izuzetka, negativne, te utiču na kvalitet njihovog života u odnosu na socijalni, zdravstveni i kulturni aspekt. Budući da je energetsko siromaštvo rezultat različitih faktora, njegovo rješavanje zahtijeva holistički pristup, kako kroz energetske tako i socijalno-političke mjere, što predstavlja novi izazov za socijalne institucije u Bosni i Hercegovini u pogledu njegovog smanjenja.
MOTIVASI PETANI MILENIAL PADA PROGRAM YESS (YOUTH ENTERPRENEURSHIP AND EMPLOYMENT SUPPORT SERVICES) DALAM USAHA BIDANG PERTANIAN DI KABUPATEN BANTAENG
Authors: Rukka Hermaya , Sirajuddin Arief , Muzakkir Muzakkir
Published: January 2024

Penelitian ini bertujuan untuk mengidentifikasi perbedaan perilaku petani dan menganalisis faktor yang berhubungan dengan motivasi petani dalam pelaksanaan Program YESS. Penelitian ini termasuk penelitian deskriptif kualitatif dan analisis kuantitatif dengan menggunakan metode survei. Teknik pengumpulan data menggunakan kuesioner dan dokumentasi. Analisis yang digunakan dalam penelitian ini adalah perhitungan nilai rata-rata dan persentase atau proporsi serta untuk mengetahui hubungan faktor internal dan faktor eksternal petani dalam pelaksanaan program YESS dianalisis dengan tabulasi silang dengan uji Tau-b Kendall's. Penelitian ini dilaksanakan di Kecamatan Bissappu, Kabupaten Bantaeng pada bulan Maret sampai Mei 2022. Bahan yang digunakan kuesioner, data primer dan data sekunder. Alat yang digunakan meliputi komputer, harddisk, flashdisk dan kamera. Hasil penelitian menunjukkan, tingkat motivasi petani milenial pada pelaksanaan Program YESS dalam usaha bidang pertanian termasuk dalam katagori tinggi (60 %) dimana motivasi tersebut berasal dari dalam diri petani (intrinsik) dan (65 %) berasal dari motivasi ekstrinsik yaitu dorongan dari luar utamanya dari lingkungan sosial, kerabat dan keluarga. Terdapat faktor karakteristik internal yang berhubungan sangat nyata positif dengan motivasi petani yaitu Lingkungan Sosial 0,250** dengan signifikan pada taraf 0,01, dan Kosmopolitan berhubungan nyata dengan nilai korelasi 0,224* pada taraf 0,05 sedangkan pendidikan tidak berhubungan nyata dengan motivasi petani milenial dengan nilai korelasi 0,035 pada taraf 0,05 dan faktor karakteristik eksternal yang berhubungan nyata positif dengan tingkat motivasi petani dalam pelaksanaan program YESS  adalah ketersedian sarana dan prasarana dengan nilai korelasi nyata positif (0,191*), ketersediaan Modal dengan nilai 0,183*, sedangkan pelatihan/magang berhubungan sangat nyata dengan nilai korelasi 0,242** pada taraf 0,01.
RESPONS PETANI TERHADAP APLIKASI PUPUK ORGANIK CAIR D.I.GROW GREEN DAN PUPUK ORGANIK KOTORAN SAPI PADA TANAMAN SAWI PAKCOY PUTIH (Brassica cinensis L.)
Authors: Kaharuddin Kaharuddin , Hambali Hambali , N. R Parawansa Ismaya
Published: January 2024

Sawi pakcoy putih (Brassica cinensis L.) merupakan sayuran yang mengandung vitamin/mineral sebagai antioksidan. Sayuran ini budidayakan petani karena meningkatnya permintaan sayuran segar guna memenuhi kebutuhan penduduk yang meningkat setiap tahun. Penelitian dilaksanakan di lahan BPP Galesong Utara Kabupaten Takalar, percobaan disusun berdasarkan rancangan acak kelompok, dengan 4 perlakuan, yaitu: P0 (tanpa pemberian POC D.I.Grow Green dan pupuk organik kotoran sapi), P1 (POC D.I.Grow Green 4 mL L-1 air dan pupuk organik kotoran sapi 4 ton ha-1), P2 (POC D.I.Grow Green 8 mL L-1 air dan pupuk organik kotoran sapi 8 ton ha-1), dan P3 (POC D.I.Grow Green 12 mL L-1 air dan pupuk organik kotoran sapi 12 ton ha-1). Perlakuan tersebut diulang sebanyak 3 kali. Kegiatan penyuluhan dilaksanakan di Kelompoktani Kampung Nene’ Galesong Utara. Parameter pengamatan, yaitu: tinggi tanaman, jumlah daun, berat segar, tingkat pengetahuan, sikap, keterampilan petani, serta efektivitas penyuluhan. Hasil penelitian menunjukkan bahwa P1 menghasilkan tinggi tanaman tertinggi pada 7 HST (11,37 cm) dan 14 HST (20,73 cm), sedangkan perlakuan P3 tertinggi pada 21 HST (27,40 cm) dan 28 HST (27,67 cm). Untuk jumlah daun, P1 tertinggi pada 7 HST (5,07 helai) dan 14 HST (8,47 helai), sedangkan perlakuan P2 tertinggi pada 21 HST (10,73 helai) dan 28 HST (13,87 helai). Untuk berat segar, P3 menghasilkan berat segar tertinggi yaitu 18 ton ha-1 dan berbeda nyata dengan perlakuan lainnya. Respons petani menunjukkan peningkatan yang signifikan, yaitu pengetahuan 35,20%, sikap (kesetujuan) 26,04%, dan keterampilan 29,17%, dengan efektivitas penyuluhan sebesar 69,44% dengan kategori efektif.
ANALISIS TINGKAT KESEJAHTERAAN PETANI KEDELAI DENGAN MENGGUNAKAN PENDEKATAN NILAI TUKAR PETANI (NTP) DAN NILAI TUKAR PENDAPATAN RUMAH TANGGA PETANI (NTPRP)
Authors: Muis Mufiidah , Marlin Syamsu
Published: January 2024

Peningkatan pendapatan petani kedelai perlu dibarengi dengan peningkatan kesejahteraan petani kedelai. Tujuan penelitian yaitu menganalisis Tingkat Kesejahteraan Petani Kedelai dengan Menggunakan Pendekatan Nilai Tukar Petani (NTP) dan Nilai Tukar Pendapatan Rumah Tangga Petani (Studi kasus Petani Kedelai di Kelurahan Leang-leang, Kecamatan Bantimurung, Kabupaten Maros). Objek dalam penelitian ini yaitu para petani kedelai di Kelurahan Leang-leang.  Penentuan dan pemilihan petani responden dilakukan secara acak (simple random sampling) dengan berdasarkan pada strata kepemilikan/pengusahaan lahan untuk komoditi kedelai yang kisaran antara 0,25 ha < n < 1 ha sebanyak 60 petani. Data yang telah diperoleh akan diolah dengan menggunakan indikator Nilai Tukar Petani (NTP) dan Nilai Tukar Pendapatan Rumah Tangga Petani (NTPRP) dan analisis data akan dilakukan dengan menggunakan metode deksriptip kuantitatif serta disajikan melalui table. Berdasarkan hasil analisa data yang diperoleh di lapangan, dapat disimpulkan bahwa analisis tingkat kesejahteraan terhadap petani kedelai di Kelurahan Leang-leang jika dilihat dengan menggunakan Nilai tukar petani (NTP) untuk petani kedelai memiliki rata- rata nilai sebesar 61,18 yang artinya petani kedelai di Kelurahan Leang-leang mengalami defisit dari usahatani kedelainya. Pendapatan dari usahatani kedelai belum mampu untuk memenuhi kebutuhan rumah tangganya. Sedangkan dengan nilai tukar pendapatan rumah tangga petani (NTPRP), terlihat bahwa petani kedelai di Kelurahan Leang-leang memiliki rata-rata nilai 0,62 yang artinya rumah tangga petani tersebut belum bisa memenuhi kebutuhannya baik itu untuk usaha pertanian maupun non pertanian.
Perbedaan Ukuran Tubuh Pedet Jantan Sapi Bali Polled Dan Sapi Bali Non Polled
Authors: Febsrianti  , Sonjaya Herry , Firmiaty Sri , Syarifuddin Syarifuddin
Published: January 2024

Sapi Bali polled adalah sapi Bali yang tidak memiliki tanduk sebagaimana sapi Bali pada umumnya.   Sapi ini memiliki keunggulan dari aspek manajemen pemeliharaan.  Tujuan dari penelitian ini adalah untuk mengetahui perbedaan ukuran tubuh pada pedet jantan sapi Bali polled dan sapi Bali non polled umur 6-8 bulan. Penelitian ini menggunakan 30 ekor sapi Bali (15 ekor sapi Bali polled dan 15 ekor sapi Bali non polled) yang diukur panjang badan, lingkar dada, tinggi badan dan lebar kepala dengan menggunakan tongkat ukur dan pita ukur. Pengukuran dilakukan sebanyak 4 kali selama 8 minggu (1 kali 2 minggu). T test adalah alat analisis yang digunakan dalam penelitian ini. Hasil penelitian menunjukkan bahwa tinggi badan dan lebar kepala memperlihatkan perbedaan yang nyata (P<0,05) antara sapi bali polled dan non polled (9,1 vs 4,9 cm dan 1,60 vs 1.07 cm)  , sedangkan lingkar dada dan panjang badan tidak berbeda nyata antara kedua keompok sapi.  Penelitian menyimpulkan  bahwa dimensi tubuh dimensi tubuh sapi Bali polled lebih tinggi dibanding dengan sapi Bali non polled.
Analisis Dampak Ekonomi Dari Penyakit Mulut Dan Kuku Terhadap Perkembangan Peternakan Sapi Potong Di Desa Masago Kecamatan Patimpeng Kabupaten Bone
Authors: Merko Miksen , Suriyana Suriyana , Juwita Sartika , Aulyani Tutik Lusyta , Beddu Hartina
Published: January 2024

Peternakan merupakan bagian yang memegang peranan penting dalam kehidupan manusia. Namun, hal ini sangat merugikan peternak ketika terjadi wabah penyakit, terutama penyakit menular. Penyakit mulut dan kuku adalah penyakit hewan yang sangat menular yang menyerang hewan berkuku seperti sapi, kerbau, domba, kambing, babi, rusa/kijang, unta dan gajah. Penyakit mulut dan kuku disebabkan oleh virus penyakit mulut dan kaku, yang termasuk dalam famili Picornaviridae dan genus Aphtovirus. Kajian ini bertujuan untuk mengetahui perkembangan peternakan sapi potong saat wabah dan pasca wabah PMK. Kajian ini menggunakan metode uji T dengan uji mann whitney test yang menggunakan  pendekatan deskriptif. Data primer diperoleh melalui pengumpulan data berupa kuesioner. Adapun responden dalam kajian ini adalah peternak yang ternaknya telah terpapar penyakit mulut dan kuku sebanyak 30 orang. Terdapat 3 variabel independen dalam kajian ini, yang terdiri dari variabel Harga ternak (X1), variabel Jumlah ternak (X2), dan variabel pengendalian penyakit (X3). Hasil analisis secara simultan variabel independen (harga, dan jumlah ternak) berpengaruh signifikan terhadap perkembangan peternakan sapi potong dengan nilai konstanta positif sedangkan pengendalian penyakit tidak berpengaruh signifikan terhadap kondisi ekonomi  dan perkembangan peternakan sapi potong di Desa Masago, Kecamatan Patimpeng, Kabupaten Bone.
Implementasi Pemetaan Strategi sebagai Dasar Pengambilan Keputusan Bisnis di PT Mitra Bussines Kuningan
Authors: Lativah Evi , Kartono Kartono
Published: January 2024

Dalam panorama bisnis yang terus berubah dengan cepat, di mana ketidakpastian dan kompleksitas menjadi bagian tak terpisahkan, organisasi dihadapkan pada tuntutan untuk mengadopsi pendekatan strategis yang cermat dan terukur. Penelitian ini bertujuan untuk menjelajahi dan menganalisis bagaimana implementasi pemetaan strategi dapat menjadi landasan yang efektif untuk pengambilan keputusan bisnis. Penelitian ini menggunakan pendekatan kualitatif untuk memahami secara mendalam implementasi pemetaan strategi sebagai dasar pengambilan keputusan bisnis di PT Mitra Business Kuningan. Dalam mengevaluasi hasil penelitian mengenai implementasi pemetaan strategi di PT Mitra Business Kuningan, dapat diambil beberapa kesimpulan kunci
The impact of Jussiaea repens aqueous extract on Hyperglycemic and Hematological markers in Diabetic male rat induced by Streptozotocin
Authors: Khandekar Tasneem , Kumar Pradhan Nirmal
Published: January 2024

In diabetic rats, the hypoglycemic potential of an aqueous extract of Jussiaea repens (50mg/100gm body weight) was examined. The herbal extract's impact on a number of hematological indicators was also studied. Eighteen albino rats, each contain 6 rats, were placed into three groups: vehicle control, diabetes control, and supplemented group. To develop diabetes, a single i.p injection of STZ (80mg/kg body weight) was given. Hematological markers include hemoglobin (Hb), red blood cell (RBC) count, white blood cell (WBC) count, packed cell volume (PCV), lymphocytes, and neutrophils, as well as blood glucose levels and HbA1c were assessed. STZ-induced diabetic rats fed the extract had lower fasting blood glucose levels, which was statistically significant (p<0.05). The HbA1c level in the diabetic control group increased drastically, but the level in the extract-treated supplemented group reduced significantly. Hb, PCV, RBC, and WBC as well as their differentials, were significantly reduced in diabetic control rats, whereas the supplemented group recovered significantly.. These findings imply that the aqueous extract of Jussiaea repens has hypoglycemic action and overcomes the abnormalities in STZ-induced diabetic rats' blood parameters.
Molecular Docking Studies of selected Erythrina variegata Leaves Alkaloids towards Estrogen Receptor (1A52 and 1GWR) and their Binding Interaction Analysis
Authors: Mari Selvi Jayaram , Murugalakshmi Mariappan , Gnanaprakash Mariappan
Published: January 2024

Medicinal plants possess many phytochemicals of great therapeutic value and many of them are effective in killing cancer cells. These compounds working by variety of mechanisms and in most of the cases they exhibit their anticancer potentiality by inhibiting many proteins involved in cell growth and division. Molecular docking is a computational approach which facilitates the finding of the best molecule from a group which may bind with the highest affinity with the intended target by providing a virtual biological system. This process works on the basis of specific algorithm and involves scoring function to rank the molecules that fit with the target. The present study has been designed to investigate the potentiality of eight alkaloids compounds from leaves of Erythrina variegata natural products and two anticancer drugs have selected and docked against Estrogen receptor proteins (PDB ID:1A52 and 1GWR) to treat cancer cells. Among them 6-hydroxy genistein ranks first with very good binding with the very good dock score with these receptors and has the potential to treat the cancer cells against the Estrogen receptor proteins 1A52 and 1GWR.
Novel “HYDALJSS08” Polyherbal Formulation Development and Ultra-Performance Liquid Chromatographic Separation, Estimation of Berberine in Cissampelos pareira Roots, Tinospora cordifolia Stems, and A Marketed Siddha-Based Polyherbal Formulation “Kabusura Kudineer.”
Authors: Jatoth Ramkishan , S.P Dhanabal , Basavan Duraiswamy , Senthil V. , Ganesh T. , M.R Jeyprakash.
Published: January 2024

The present study aims to develop and document an analytical method for Berberine in the chloroform fraction of Cissampelos pareira (Menispermaceae)roots, Tinospora cordifolia (Menispermaceae) stems, and Polyherbal formulations (Marketed & Developed). During the pandemic Covid-19 ministry of Ayush, Govt of India was recommended a Siddha-based polyherbal formulation known as “Kabusura Kudineer” for immune booster and treatment of Covid -19. False pareira roots having active biomarker substances are BBE proved for its activity of Anti-viral, and immunomodulatory. Preliminary identification of Berberine in chloroform fraction of Cissampelos pareira roots, Tinospora cordifolia stems was done by the TLC, mobile phase used as a Toluene: Acetone: Water (5:15:1) and Chloroform: methanol (70:20). The UPLC was performed on a column, X Bridge BEH C18 Column, 130Å, 3.5µm, 4.6mm X 150mm, 1/pk and Solvent system were 0.1% Trifluoroacetic acid: Methanol (60:40). The effluents were observed at 272nm in UV detector. The Rf value of Berberine, Chloroform fraction of Cissampelos pareira roots was 0.23, and the Tinospora cordifolia stems was 0.63. The valid UPLC method parameter for BBE is system precision, SD (5433.07), the Regression equation was found y = 20570 x−182430, Correlation coefficient (R2) 0.9993. The adequate Linearity concentration was found to be 50 to 150µg/ml, LODs (4.02µg/ml), LOQs (12.17µg/ml), Method precision for intraday, Interday %RSD (0.7), (1.4), SD (16064.5), (32811.5), Recovery 98%, and 102%. BBE content was found in a formulation (“KabusuraKudineer” churna- 20.9360µg/ml, Developed Hydroalcoholic Polyherbal formulation - 21.4370µg/ml), and the Chloroform fraction of Cissampelos Pareira roots (CHFCP), Chloroform fraction of Tinospora cordifolia stems (CHFTC) was 28.9090µg/ml and 73.2050µg/ml. The developed liquid chromatography (UPLC) methods have enabled simple, rapid, easy, accurate, reproducible, and linear analysis of BBE in Chloroform fraction of velvet roots, Tinospora cordifolia stems, and Ayurvedic, Siddha -based Polyherbal formulations.
The effect of Chronic treatments of Type 2-diabetes mellitus on COVID-19 Morbidity and Symptoms Severity
Authors: Mamari Rozalia , Ibrahim Rama
Published: January 2024

Coronavirus disease 2019 (COVID-19) is a highly contagious viral disease that causes the severe acute respiratory syndrome (SARS), and has had a disastrous impact on demographics around the world. Studies have classified type 2-diabetes mellitus (T2DM) as a risk factor for increasing mortality and se-verity of disease symptoms. However, the effect of different T2DM-chronic medications on disease progression is still unclear. The aim of this study was to determine the effect of glycemic control on COVID-19-related mortality and symptom severity, as well as the impact of commonly used T2DM therapeutic approaches on disease outcomes. This study included 109 COVID-19 patients with (68 patients) or without (41 patients) type 2-diabetes mellitus. Diabetic patients were further classified according to: 1) their glycemic control [HbA1c levels ˂6.5% (Well-controlled) and ≥ 6.5% (Less-controlled)], or 2) their pre-hospital anti-hyperglycemic med-ication [metformin (50%) or sulfonylureas (50%)]. Our results showed that diabetes is associated with a significantly higher risk of death in COVID-19 pa-tients. We also found that metformin treatment reduces plasma C-reactive protein levels and mortality Compared with sulfonylureas, and continuing with metformin during the hospital stay had a better prog-nostic for survival. We also, demonstrated that taking sulfonylurea is associated with an increase in COVID-19 mortality as compared to metformin by increasing cardiovascular events.
Bio-analytical Method for the Pre-clinical Estimation of Donepezil Hydrochloride in Rabbit Plasma by RP-HPLC
Authors: Surya Anusha Venna R , RVS Chaitanya Koppala , Aleti Rajeswari , Ramana Murthy Kolapalli Venkata
Published: January 2024

A simple, reliable and sensitive RP-HPLC bioanalytical method with PDA as detector was developed for the estimation of donepezil HCl in the rabbit plasma and validated. The biological samples were extracted and analysed using loratadine as internal standard. The sample analysed with Inertsil ODS 150mm x 4.6mm, 5.0µm particle size column using 70:30 v/v of 0.1% trifluoroacetic acid and acetonitrile mobile phase at flow rate of 1mL/min. All the parameters validated were within the limits proposed in bioanalytical method validation guidelines. The linearity was observed in the range of 5-200ng/mL with LOD of 0.9ng/mL. The method was observed to have short analysis time of 6 min and also found to be successful in studying the pharmacokinetic parameters of donepezil HCl.
Screening of selected Medicinal plants for its potential to inhibit Biofilm Formation and Virulence factor production by Pseudomonas aeruginosa PAO1
Authors: M. Rajeswari
Published: January 2024

Pseudomonas aeruginosa is a virulent human pathogen which exerts its pathogenicity with the aid of various factors namely biofilm formation, virulence factors production, and motility mechanisms. Increase in the rate of resistance mechanisms against conventional methods of treatment has led to the discovery of alternative approaches to treat its pathogenesis associated ailments in humans. In this study, we have screened four medicinal plants namely Amomum subulatum, Holarrhena pubescens, Laurus nobilis, and Punica granatum for their antibiofilm and antiquorum sensing activity. Initially, the plants were extracted using methanol and their minimum inhibitory concentration (MIC) were determined by microbroth dilution method. The MIC of A. subulatum, H. pubescens, L. nobilis, and P. granatum was found to be 4mg/ml, 0.5mg/ml, 6.25mg/ml, and 25 mg/ml, respectively. Further, at sub-MICs, all the four extracts inhibited the formation of biofilm in P. aeruginosa PAO1 without affecting its growth. The highest inhibitory percentage on biofilm formation (67%) was exhibited by L. nobilis. The impact of extracts on exopolysaccharide (EPS) production was investigated which revealed that production of EPS decreased with increase in sub-MICs. The influence of extracts on production of virulence factors in P. aeruginosa PAO1 namely pyocyanin, rhamnolipids, and alginate were evaluated. Among the four extracts, A. subulatum exhibited the maximum inhibitory activity at its sub-MIC of 2 mg/ml on production of pyocyanin, rhamnolipids, and alginate. Finally, swimming and swarming motility behaviors in P. aeruginosa PAO1 was also affected on treatment with sub-MICs of the plant extracts with greatest effect shown by A. subulatum and P. granatum. Hence these findings may provide an underlying knowledge on identification of new antibiofilm and antiquorum sensing compounds for treating biofilm-related infections caused by P. aeruginosa.
Literature Review of Hematology Division The Mechanism of Imanitib Resistance in Chronic Myeloid Leukemia
Authors: Dari Selatan Mutiara , Hernaningsih Yetti
Published: January 2024

Chronic Myeloid Leukemia (CML) refers to a kind of malignancycharacterized by the clonal proliferation of myeloid leukocytes in the bone marrow. The World Health Organization (WHO) classifies CML as a Myeloproliferative Neoplasm (MPN) identified by the proliferation of granulocyte cells without differentiation disorders. As a result, peripheral blood smears display varying levels of differentiation within the granulocyte series. Furthermore, the translocation between chromosomes 9 and 22 gives rise to the Philadelphia chromosome (Ph) (BCR-ABL1). Imatinib mesylate (GleevecTM), a chemotherapeutic belonging to the protein kinase inhibitor group, is the first-generation Tyrosine Kinase Inhibitor (TKI) used for treating chronic phase CML. Imatinib mesylate suppresses cancer cell signals and inhibits a sequence of chemical events that contribute to cell growth and development. It achieves this by binding to the ATP binding region, trapping it in a self-inhibited or closed conformation, and exerting non-competitive suppression on protein enzyme activities. Consequently, this procedure leads to the inhibition of leukemogenesis-promoting signaling pathways.Imatinib resistance poses a significant challenge, and it can be classified as primary or secondary resistance based on the onset time. Depending on the mechanism, resistance can be characterized as BCR-ABL1-independent or BCR-ABL1-dependent. The most prevalent mechanism of imatinib resistance is the mutation of the ABL kinase domain, followed by BCR-ABL1 amplification and overexpression. In cases of inadequate response or treatment failure, the European Leukemia Network (ELN) recommends mutation screening before transitioning to second-generation Tyrosine Kinase Inhibitors (TKIs). Mutations of the BCR-ABL1 kinase domain can be analyzed using alternative examination methods such as Sanger sequencing, Next-Generation Sequencing (NGS), and digital Polymerase Chain Reaction (dPCR).Various methods have been employed to enhance therapy response or treat TKI-resistant patients, including increasing the dose of Imatinib, utilizing next-generation Tyrosine Kinase Inhibitors, and resorting to bone marrow transplantation.
Protective effect of Galantamine on attenuating Cisplatin-induced Neurotoxicity: An In-vitro and In-vivo approach
Authors: Kumar Sahu Vikram , Melani Hariyadi Dewi , Lanchhana Dash Sribatsa , Sharma Nitin , Karwasra Ritu
Published: January 2024

Galantamine is a drug of choice for the treatment of Alzheimer's disease and possesses antioxidant, anti-inflammatory and cholinomimetic as non-FDA-approved indications. This study designed to explore the impact of Galantamine to attenuate cisplatin-induced neurotoxicity and oxidative stress. Experimental animals were segregated into five groups viz-a-viz group I as normal control, II as cisplatin control, and III-V as galantamine at varying doses, low (2.5mg/kg), medium (5mg/kg) and higher (10mg/kg). All the samples were orally administered, daily for 14 days. Cisplatin was injected intraperitoneally on day 8 to all groups except normal control. Assessment of neurotoxicity was done by measurement of a balance of antioxidant (GSH, SOD) and pro-oxidant (MDA), histopathological investigations. Dose-dependent significant (p<0.05) reduction in neurotoxicityhas been found by galantamine with reduction (p<0.01) in oxidant stress markers. Pronouncedreduction in apoptosis and elevation of disturbed hematological, and biochemical alterations were also observed with significance of p<0.001 in galantamine groups. We have observed that galantaminedose-dependentlyattenuates neurotoxicity, and oxidative stress, reversed the histopathological alterations and inhibits activated pro-inflammatory mediators (TNF-α). The research work provides drug repurposing of galantamine and providespreliminary ground for the treatment and management of cisplatin-induced neurotoxicity towards the clinical domain.