bluuebunny/crossref_metadata_2025 huggingface dataset:
Tumor suppressor functions of DAXX through histone H3.3/H3K9me3 pathway in pancreatic NETs
Authors: Ueda Hiroki , Akiyama Yoshimitsu , Shimada Shu , Mogushi Kaoru , Serizawa Misaki , Matsumura Satoshi , Mitsunori Yusuke , Aihara Arihiro , Ban Daisuke , Ochiai Takanori , Kudo Atsushi , Tanabe Minoru , Tanaka Shinji
Published: March 2018

Pancreatic neuroendocrine tumors (PanNETs) have considerable malignant potential. Frequent somatic mutations and loss of DAXX protein expression have been found in PanNETs. DAXX is known as a transcriptional repressor; however, molecular functions underlying DAXX loss remain unclear in PanNETs. We evaluated DAXX expression by immunohistochemistry in 44 PanNETs.DAXX-knockdown (KD) and -knockout (KO) PanNET cells were analyzed forin vitroandvivo. The target genes were screened by microarray and chromatin immunoprecipitation (ChIP) assays for DAXX, histone H3.3 and H3K9me3 complex. In clinicopathological features, low DAXX expression was significantly correlated with nonfunctional tumors, higher Ki-67 index and WHO grade. Microarray and ChIP assays ofDAXX-KD/KO identified 12 genes as the direct targets of DAXX transcriptional repressor. Among them, expression of five genes including STC2 was suppressed by DAXX/H3.3/H3K9me3 pathway.DAXX-KD/KO cells enhanced sphere forming activity, but its effect was suppressed by knockdown ofSTC2. In xenograft models, tumorigenicity and tumor vessel density were significantly increased inDAXX-KO cells with high expression of STC2. Clinically, higher recurrence rate was recognized in PanNETs with low expression of DAXX and high expression of STC2 than others (P = 0.018). Our data suggest that DAXX plays as a tumor suppressor and DAXX/H3.3 complex suppresses target genes by promoting H3K9me3 in PanNETs. Combination of DAXX loss and its target gene STC2 overexpression might be effective biomarkers and therapeutic candidates.
Single drug biomarker prediction for ER− breast cancer outcome from chemotherapy
Authors: Chen Yong-Zi , Kim Youngchul , Soliman Hatem H , Ying GuoGuang , Lee Jae K
Published: March 2018

ER-negative breast cancer includes most aggressive subtypes of breast cancer such as triple negative (TN) breast cancer. Excluded from hormonal and targeted therapies effectively used for other subtypes of breast cancer, standard chemotherapy is one of the primary treatment options for these patients. However, as ER− patients have shown highly heterogeneous responses to different chemotherapies, it has been difficult to select most beneficial chemotherapy treatments for them. In this study, we have simultaneously developed single drug biomarker models for four standard chemotherapy agents: paclitaxel (T), 5-fluorouracil (F), doxorubicin (A) and cyclophosphamide (C) to predict responses and survival of ER− breast cancer patients treated with combination chemotherapies. We then flexibly combined these individual drug biomarkers for predicting patient outcomes of two independent cohorts of ER− breast cancer patients who were treated with different drug combinations of neoadjuvant chemotherapy. These individual and combined drug biomarker models significantly predicted chemotherapy response for 197 ER− patients in the Hatzis cohort (AUC = 0.637, P = 0.002) and 69 ER− patients in the Hess cohort (AUC = 0.635, P = 0.056). The prediction was also significant for the TN subgroup of both cohorts (AUC = 0.60, 0.72, P = 0.043, 0.009). In survival analysis, our predicted responder patients showed significantly improved survival with a >17 months longer median PFS than the predicted non-responder patients for both ER− and TN subgroups (log-rank test P-value = 0.018 and 0.044). This flexible prediction capability based on single drug biomarkers may allow us to even select new drug combinations most beneficial to individual patients with ER− breast cancer.
Critical Disability Studies at the Edge of Global Development: Why Do We Need to Engage with Southern Theory?
Authors: Nguyen Xuan Thuy
Published: March 2018

This paper examines critical disability studies through the lens of Southern theory–a theoretical perspective on the process of knowledge production in social sciences which embodies intellectual projects from the global South (Connell, 2007). Building on Helen Meekosha’s question on decolonizing disability (2011), I critique the domination of Northern disability studies by proposing an engagement with Southern theory. My argument is three-fold: First, the use of Southern theory enables us to interrogate the domination of Northern epistemologies in Southern contexts; second, this theory unveils how colonialism has continued to manifest itself through the knowledge practices which have made the experiences of disabled people in the global South invisible; and finally, situated within the context of global development, this theory enables critical disability studies to act as a project of decolonization that engages with Indigenous ways of knowing about disability experiences.
Songs From the Dairy Section: Working with Disability & Dignity
Authors: Fine Zoe Dupree
Published: March 2018

This essay opens with, “The idea of duty in one’s calling prowls about in our lives like the ghost of dead religious beliefs” (Weber, 1958, p. 182), words that encourage us to consider the idea of duty in one’s calling. If duty in one’s calling prowls about in our lives like a ghost, it haunts us. This is so because it is ever-present, and it is important to us. Weber’s words lead us to contemplate what having a calling means, what significance work should have, and what the purpose is of the work that we do when we do our jobs. What is the aim? Why have a job?
Physicians' Perceptions of Barriers to Equal Access to Reproductive Health Promotion for Women with Mobility Impairment
Authors: Joseph Meera , Saravanabavan Sujen , Nisker Jeff
Published: March 2018

In Canada, 15% of women report having a disability, most frequently mobility-related. Research with women with disabilities has for decades brought attention to barriers to reproductive health promotion. Research with physicians regarding why these barriers exist and how they can be dissolved has not occurred. Physicians were recruited through email and pamphlets to participate in 30-45 minute in-person interviews, audiotaped and transcribed verbatim.  Charmaz-based qualitative analysis was supported by NVivo10TM software. Twenty-five interviews were conducted before theoretical sufficiency. Six themes were co-constructed: I-Physicians’ Perceptions of Barriers; II-Physicians' Perceptions of Consequences of Barriers; III-Resolving Barriers; IV-Physicians’ Sub-Understanding of Legal Right to Accommodation; V-Obligation of Physicians to Advocate for Accommodation; and VI-Language Suggesting Physicians’ Lack of Understanding of How Persons with Disabilities See Themselves and Want to be Seen. Physicians identified physical access barriers previously identified in critical disability studies literature, but did not identify the barriers of physician attitudes and lack of information provision as reported in this literature. Physicians perceived their additional time for pap smears and other surveillance strategies as barriers, particularly when not remunerated. Physicians were unaware of their legal obligation to accommodate under human rights codes, perceiving that taking extra time to provide accommodation was doing so out of the "goodness of your heart". Physicians used language illustrating many were unaware of how disabled persons see themselves and want to be seen. Education regarding disability rights and culture must be introduced immediately and prominently into all levels of medical education, with the educators being people with disabilities.
Review of Burstow (Ed.), Psychiatry Interrogated: An Institutional Ethnography Anthology (2016).
Authors: Johnston Matthew S.
Published: March 2018

This volume interrogates the psychiatric apparatus with an evidentiary scorn and authority that demands accountability and an apologetic response. This scathing indictment of psy-professionals who mobilized psychiatric knowledge and practices to degrade, torture, and gravely harm others will serve to (1) educate skeptics; (2) bolster activism and solidarity in the Mad Movement; (3) vindicate survivors of psychiatric violence and coercion who often experience their suffering and struggle in a void of isolation; (4) provide hope to the many disgruntled professionals working in the mental health field who question their assumed role in helping people; and (5) draw ferocious critique from countless agents who wholeheartedly defend the idea that psychiatry can/will/does help/treat/cure sickly people, whether with complete, partial, or entirely without our consent.
Review of Wexler, Autism in a Decentered World (2016).
Authors: Nadesan Majia H.
Published: March 2018

Alice Wexler’s Autism in a Decentered World offers a novel epistemology of autism that valorizes autistic ways of experiencing by celebrating the artistic expressions of self-identified autistic people. Wexler launches her project to valorize autistic experience by first deconstructing the narrative fiction upon which modernist conceptions of neurological normality, or neurotypicality, were founded.
Development of oil, freeze, high temperature resistant and flame retardant rubber compounds for high performance hydrolic hose
Authors: KARADENİZ Kemal
Published: March 2018

The high
performance hydrolic rubber hose should resist to hydrolic oils and can run at
temperature interval from –55 0C to 150 0C. In addition
to these properties, for some areas such as mining should also be flame
retardant. In this study, compound formulations having properties mentioned
above were developped, mechanical properties, hydrolic oil and low, high
temperature resistance performances were measured. Flame retardant tests were
also been performed. Hoses were built using these newely developped compounds
and then their burst tests were performed. The best performer compound for low
temeperature performance hose was the one prepared with the blends of acrylonitrile
butadiene (NBR), stirene-butadiene  (SBR)
and cis-butadiene (CBR) rubbers along with plasticizer diisononylphthalate (DINP).
One of the compounds preapared with the blending of SBR, NBR rubbers, aluminium
hydroxide, tricrezyl phoshate (TCP) and zinc borate was the best for the flame
retardant hose. The best performer high temeperature resistant compound was
preapred using MT N990 carbonblack and plasticizer paraplex G50 with blending
of SBR 1502, NBR 2860 and NBR 3360 rubbers.
Participação econômica das atividades de subsistência na agricultura familiar
Authors: Breitenbach Raquel
Published: March 2018

O presente artigo compreende um Estudo de Casos Múltiplos acerca da importância econômica das atividades de subsistência para a agricultura familiar de duas regiões do Rio Grande do Sul. O Brasil possui características diversas quando o assunto é agricultura. Dentre essa diversidade, destaca-se com importância social e econômica a agricultura familiar, que engloba um percentual significativo da população no campo, gerando emprego e renda. Porém, essa agricultura familiar é heterogênea, já que dentro de um mesmo estado, como o caso do Rio Grande do Sul. Existe uma diversidade de situações nesse setor e, de modo especial estudado neste trabalho, essa diversidade pode refletir nas atividades de subsistência e na sua participação econômica distinta. Para tanto, este estudo levantou dados empíricos em duas distintas regiões do Estado, Missões e Norte, visando identificar características que distinguem a agricultura familiar das duas realidades. O objetivo do estudo foi identificar a participação econômica das atividades de subsistência comparativamente com as atividades comerciais da agricultura familiar de Dezesseis de Novembro (Região Missões) e Sertão (Região Norte) no Rio Grande do Sul, identificando fatores de heterogeneidade do setor. Para que o estudo fosse possível, foram selecionadas cinco unidades de produção agropecuária familiares representativas do setor em cada município. Como principal resultado, destaca-se que as atividades de subsistência são desenvolvidas em maior número e têm maior participação econômica, se comparadas às atividades comerciais, na agricultura familiar de Dezesseis de Novembro do que na de Sertão.
Functional Scenarios for the Revitalization of the Port of Pelotas, State of Rio Grande do Sul, Brazil
Authors: Domingues Marcelo Vinícius De la Rocha , Bandeira Letícia De Magalhães
Published: March 2018

O presente estudo teve por objetivo delinear três cenários funcionais para o Porto de Pelotas, localizado no centro do maior sistema lagunar costeiro do País, situado na Planície Costeira do Estado do Rio Grande do Sul, Brasil, com o intuito de nortear os tomadores de decisão quanto ao planejamento de ações estratégicas para sua revitalização econômica, considerando que este Porto, presentemente, vem sendo alvo de interesses político-econômicos em nível local, regional e bi-nacional. Os resultados alcançados se resumem em um levantamento da sua atual situação funcional, além do delineamento de três cenários futuros, baseados em alternativas funcionais estabelecidas para o mesmo. Para tanto, foram utilizadas as metodologias de pesquisa exploratória, além da análise SWOT, prospecção de cenários e entrevista semi-estruturada com atores chave para a pesquisa. Concluindo este artigo, constata-se que, apesar de sua atual relativa estagnação econômico-funcional, o Porto de Pelotas apresenta condições para desempenhar um novo e importante papel no processo de retomada do desenvolvimento econômico da metade sul do Rio Grande do Sul, bem como do desenvolvimento integrado da Bacia da Lagoa Mirim através da hidrovia bi-nacional Brasil-Uruguai.
La traversée de l’Atlantique ou la mort ? Une réflexion critique sur la notion d’échange
Authors: Mwepu Patrick Kabeya
Published: March 2018

rossing the Atlantic or dying? Critical reflexion on the concept of exchange

This paper investigates the validity of the concept of "cultural exchange" through a few African novels, comparing different perspectives of journeys. While some African writers attempt to depict their most immediate environment, making themselves appear as nationalist as possible, one can notice however that more and more other African writers choose to encapsulate their literary universe in changing geographic settings: Their writing depicts the mobility of characters aiming at reaching new frontiers. These new spaces, always to be discovered, provide African writers with a platform to depict subjectivities that cognitively enrich themselves on contact with newer and different world visions. However, the crossing into the other world (on the other bank of the river) seems not always to offer a space for mutual cultural exchange; it might be fatal and lead to identity "assassination" , "a journey of death".
The writing of Arthur Fula: modernity, language, place and religion
Authors: Willemse Hein
Published: March 2018

Arthur Fula's debut novel Jôhannie giet die beeld (Lit: Johannesburg moulds the graven image) was well received in the beginning of 1954 but has in recent years been largely forgotten. The novel was promoted as the first "by a Bantu in Afrikaans", a designation that differentiated him, a third language speaker, from the typical Afrikaans writer who was ordinarily a  white, first language speaker. The novel registers, in the tradition of the ˜'Jim-comes-to Jo'burg novels', the migration of black characters to the urban areas with the persistent struggle between indigenous traditions and the presence of an unknown, even threatening Western modernity. In his second novel Met erbarming, O Here (With Compassion, Oh Lord, 1957) Fula made peace with the permanency of urban black Africans and their aspirations. This essay introduces the emergence of the autodidact Fula's authorship amidst a period of profound change and adaptation in South Africa during the 1950s, tracing his personal history, the circumstances of his writing and choice of language, and the reception of his debut novel.
Indigeneity in modernity. The cases of Kgebetli Moele and Niq Mhlongo
Authors: Rafapa Lesibana
Published: March 2018

The study of South African English literature written by black people in the postapartheid period has focused, among others, on the so-called Hillbrow novels of Phaswane Mpe and Niq Mhlongo, and narratives such as Kgebetli Moele's Book of the Dead (2009) set in Pretoria. A number of studies show how the fiction of these writers handles black concerns that some critics believe to have replaced a thematic preoccupation with apartheid, as soon as political freedom was attained in 1994. However, adequate analyses are yet to be made of works produced by some of these black writers in their more rounded scrutiny of the first decade of democracy, apart from what one may describe as an indigenous/traditional weaning from preoccupation with the theme of apartheid. This study intends to fill this gap, as well as examine how such a richer social commentary is refracted in its imaginative critique of South African democratic life beyond its first decade of existence.Â  I consider Mhlongo's novels Dog Eat Dog (2004) and After Tears (2007); together with Moele's narratives reflecting on the same epoch Room 207 (2006) and The Book of the Dead (2009). For the portrayal of black lives after ten years of democracy, I unpack the discursive content of Mhlongo's and Moele's novels Way Back Home (2013) and Untitled (2013) respectively. I probe new ways in which these postapartheid writers critique the new living conditions of blacks in their novelistic discourses. I argue that their evolving approaches interrogate literary imaginaries, presumed modernities and visions on socio-political freedom of a postapartheid South Africa, in ways deserving critical attention. Â I demonstrate how Moele and Mhlongo in their novels progressively assert a self-determining indigeneity in a postapartheid modernity unfolding in the context of some pertinent discursive views around ideas such as colourblindness and transnationalism. I show how the discourses of the author's novels enable a comparison both their individual handling of the concepts of persisting institutional racism and the hegemonic silencing of white privilege; and distinguishable ways in which each of the two authors grapples with such issues in their fiction depicting black conditions in the first decade of South African democratic rule, differently from the way they do with portrayals of the socio-economic challenges faced by black people beyond the first ten years of South African democracy.
Discrete-Continuous Approach and Terminology: Description of Energy-Information Interaction
Authors: Lopatiev A. , Pytyn M. , Bernatowski A.
Published: March 2018

The objective is to study definitions that describe energy-information interactions under a discrete-continuous approach to the model of person.

Materials and methods. The research used the general scientific methodology of systems analysis. According to it, a scientific and theoretical study does not consider relatively independent components separately, but in a combination, in a system with others. A systems approach made it possible to reveal integrative, systematic features and qualitative characteristics absent in individual elements forming the system. To define the terminology that describes energy-information interactions, the research used a discrete-continuous approach. The research object was the existence of appropriate terminology that meets the requirements of modern science.

Results. The paper presents a model describing a person in the form of a discrete-continuous system, with the focus on energy aspects and information technology. Information technology systemizes knowledge representation, creates logical and computational tools for establishing regularities from primary information arrays, constructs information systems. The research clarified the following terms: infotomation is obtaining information knowledge on the layer-by-layer structure of the study object organization; information indicators are natural indicators transformed into a normalized relative form, according to the natural indicator position on the scale of its change. The form makes it possible to obtain an information evaluation of the system state by this indicator; information model is an information knowledge in a formula or algorithmic form.

Conclusions. The research studied the definitions that describe energy-information interactions for the systems of material points and continuous medium.
Discrimination between Chinese Localizers Fujin and Pangbian
Authors: Zhang Ying
Published: March 2018

This paper discriminates between the tricky Chinese localizers in TCSOL fujin (附近) (nearby) and pangbian (旁边) (beside; by). Through a comparative analysis, three rules for the choice of them are identified: Use fujin rather than pangbian when barrier exists, use fujin to express spatial relationship and pangbian for horizontal relationship, and use both with quantity phrases yet only fujin with indefinite quantity phrases. The research is hoped to facilitate the two localizers’ acquisition and contribute to the existing inadequate literature in the study of such Chinese localizers.
The Modality System and the Emotional Appeals: An Interpersonal Interpretation of Roosevelt’s Speeches
Authors: Dou Xiaoli , Yang Wendi
Published: March 2018

This article takes Franklin D. Roosevelt’s four inaugural speeches as objects of study, and mainly uses the modality system in Halliday’s systemic functional grammar as theoretical framework. This paper, from a functional-stylistic perspective, tries to investigate the close relationship between the modality system and the interpersonal function, i.e. its emotional appeals to the audience, underlying those typical linguistic markers, hence to uncover Roosevelt’s unmatched linguistic competence and speaking techniques. Our study shows that Roosevelt prefers modalization to modulation. As for modulation, obligation covers 18.70% signaling the speaker’s degree of pressure on the audience to take positive action, and inclination appears frequently, covering 13.01%, and is mainly realized by finite modal operators or adjectives, showing Roosevelt’s willingness to do something for his country and people. Through these sparkling speeches, his wisdom and intelligence, capability and responsibility, prestige and power are fully demonstrated.
Translation of Classics by JX Native Literati of Song Dynasty under Foregrounding Theory
Authors: Li Yuying , Gao Yaping
Published: March 2018

As a symbolic feature of the language forms of literature, foregrounding is closely connected with the theme and aesthetic value of literary works. Through an analysis of some classics by Jiangxi native literati in Song Dynasty, the thesis focuses on the significance of foregrounding theory to literary translation or even to general translation. With a case study of the classics from four aspects of foregrounding theory, namely, phonological deviation, lexical deviation, semantic deviation and graphological deviation, the research would illustrate foregrounding language in literature and its applicability to classics translation in detail.
THE INFLUENCE OF HYPERCAPNIA FOR RESISTANCE TO STRESS AND SPONTANEOUS LOCOMOTOR ACTIVITY OF DROSOPHILA MELANOGASTER DIFFERENT LINES
Authors: Chaka E. , Plotnikova L. , Levashov M. , Yanko R. , Litovka I. , Beresovskiy V.
Published: March 2018

The effect of hypercapnia for resistance to fruit flies hyperthermic stress, life expectancy at alimentary and water deprivation and spontaneous locomotor activity. Canton-S and Oregon-R test Drosophila lines were divided into low and high are resistant to the action of carbon dioxide and contained in hypercapnic gas medium (5 % CO2) for seven generations. Under the influence of hypercapnia increased resistance to fruit flies hyperthermic stress. Life expectancy line Drosophila Canton-S high are resistant to the action of CO2 alimentary conditions of water deprivation increased 5 % and time of extinction of a half of individuals to 19 % compared with the control. In Drosophila line Oregon-R low and high are resistant to the action of CO2. the average life expectancy had a tendency to decrease i7-8 % compared with the control. It is shown that the spontaneous motor activity of both drosophila lines highly resistant to CO2 was higher compared to the low resistant. The number of flies with a positive phototaxis after adaptation to hypercapnia reduced in Drosophila all the experimental groups.
The psychosocial development of High-Status, Average Status and Low-Status Servicemen for a Fixed Period
Authors: Ilyin V.A. , Svirin D.V.
Published: March 2018

The article presents the results and their interpretation analysis of a research of interrelationship between status-role position of the individual in the informal intergruppo structure of closed communities and the peculiarities of his psychosocial development (as an example, army units, brought up by servicemen for a fixed period). The study was elaborated and implemented on the basis of the theory of psychosocial development. The empirical base of the study consists of high secret army units, i.e. real closed communities. In total 13 such kind of groups took part in the research. The integral status of group members in the structure of interpersonal relations was calculated in each of them, according to the results of sociometry, referencemetrical procedures and methodical technique of identifying the informal intergruppo structure of power in a contact community, being used the algorithm by Kondratiev M.Y. The peculiarities of psychosocial identity of the subjects were revealed simultaneously with using the technique of “differential of psychosocial development”. On the bases of the obtained data analysis it was shown that the level of psychosocial development of higher status members in closed communities is essentially lower than of average status and low-status ones. The detailed explanatory scheme of this phenomenology was presented, being used psychosocial development theory as the basic interpretive key.
O BRASIL E O ÁRTICO
Authors: Santos Leo Evandro Figueiredo dos , Júnior Enoil De Souza , Filippi Eduardo Ernesto , Simões Jefferson Cardia
Published: March 2018

Este artigo apresenta a definição geográfica do Ártico e identifica o regime internacional complexo que se consolida, sobre as águas e fundos marinhos internacionais do Oceano Ártico e mares adjacentes. Este regime tem com fundamento base a aplicação da Convenção das Nações Unidas Sobre o Direito do Mar (CNUDM). Da mesma forma, argumenta sobre preocupações, interesses e mudanças sobre a Região Ártica, o que envolve temas como: meio ambiente, mudanças climáticas, desenvolvimento sustentável, exploração de recursos, especialmente pesqueiros e petróleo e gás, as (novas) rotas marítimas, estratégia e segurança, considerando possíveis disputas territoriais, mas, principalmente, especula sobre a possibilidade dos efeitos das mudanças climáticas sobre aquela região gerarem impactos sobre o espaço e o meio brasileiro e sul-americano. A partir desses pressupostos infere sobre a inserção brasileira na região, por meio do desenvolvimento da pesquisa científica associada, da adesão do Brasil ao Conselho Ártico (CA), ao International Arctic Science Committee (IASC) e ao Tratado de Svalbard e da sua atuação na Nações Unidas, principalmente perante a CNUDM e a Comissão de Limites da Plataforma Continental (CLPC) e outros regimes em que são debatidas as questões pertinentes ao Ártico.
INTEGRAÇÃO SOCIOESPACIAL DOS BAIRROS DE HABITAÇÃO SOCIAL NA ÁREA METROPOLITANA DE LISBOA: EVIDÊNCIAS DE MICRO SEGREGAÇÃO
Authors: Carreiras Marina Gaboleiro
Published: March 2018

Este artigo reflete sobre a condição urbana dos bairros de habitação social na Área Metropolitana de Lisboa (AML), no que se refere à integração socioespacial e relações desta com o desenvolvimento urbano, as políticas públicas e estratégias locais de atuação nos bairros. O estudo assume uma perspetiva multiescalar, que parte de uma análise extensiva dos bairros sociais no país e na AML, para chegar a um estudo intensivo da situação de três bairros localizados em municípios distintos da Grande Lisboa. Para a concretização da investigação, para além da análise bibliográfica, recorre-se a uma combinação de métodos quantitativos, qualitativos e cartográficos.Os resultados evidenciam lacunas na integração socioespacial dos bairros de promoção municipal a múltiplos níveis geográficos e confirmam a existência de desigualdades socioespaciais enquanto fenómeno multinível que se expressa em diversas dimensões analíticas, designadamente a funcional, a física, a simbólica e a relacional. Contribuem para estes défices de integração socioespacial, o reduzido parque de alojamento social, o seu direcionamento quase exclusivo para as famílias insolventes, a edificação dos empreendimentos num contexto de desarticulação urbana e os limitados impactos dos programas, práticas e ações sociais e socioterritoriais incidentes nos bairros, no que se refere a contributos efetivos para a sua integração socioespacial.
A comparative study of 25 mcg vs 50 mcg of vaginal misoprostol for induction of labour
Authors: Aggarwal Amika , Pahwa Sangeeta
Published: March 2018

Background: The objectives of the current study were to compare the efficacy and safety of 25μg and 50μg of intravaginal misoprostol for induction of labor at term and to study the maternal and fetal outcome.Methods: A Prospective Study was done on 50 cases with 25μg misoprostol and 50 cases of 50μg of misoprostol intravaginal, repeated every 6 hourly till adequate uterine contractions or maximum 5 doses. Total dose of induction, induction delivery interval, mode of delivery, maternal and fetal outcome were recorded.Results: Mean induction delivery interval was 13.8±5.9 and 14.0±5.7 hours (P=0.9) with the 25μg and 50μg misoprostol respectively. The 25μg misoprostol group had a lower delivery rate with a single dose compared with the 50μg group (38% and 42% respectively). However, 25μg group had more deliveries than 50μg group with increasing number of misoprostol doses (36% vs. 38%, and 20% vs. 16% for 2 doses and 3 doses respectively). The need for oxytocin augmentation among participants was higher in the 25μg group (20%) than in 50 μg group (16%).This was however not statistically significant (P=0.603). At lesser initial bishop score, with 50µg misoprostol less doses are needed as compared to 25 µg and hence induction delivery interval decreases. The rates of caesarean section and operative vaginal delivery were similar in both groups. There was no significant difference in maternal side effects and neonatal outcomes among the women in the two groups.Conclusions: The 25 µg of intravaginal misoprostol administered six‑hourly appears to be as effective but safer than 50 µg for induction of labor. The use of 50 µg misoprostol may be recommended when there is a need to expedite vaginal delivery especially in cases of lesser initial bishop score.
Evaluation of clinicopathological profile of subjects with intrauterine fetal death
Authors: Pandey Sunil Kumar , Porwal Surabhi
Published: March 2018

Background: Intrauterine foetal death is an immense emotional burden for everyone concerned specially in the last trimester. Therefore, it is very important to find out, what has happened. Evaluation of clinical and pathological profile of women presenting with intrauterine foetal death has evoked great interest among the obstetricians.Methods: The prospective observational study was conducted in the department of Obstetrics and Gynaecology N.S.C.B. Medical College Jabalpur during 1st June 2012 to 31st October 2013. A total of 155 intrauterine foetal death subjects admitted during this period were evaluated. Clinically and laboratory profile of subjects done.  Histomorphology of placenta was performed in each case. Full HPR finding were then correlated with clinical and laboratory findings of subjects.  Results: Poor vascularity of villi and fever were significantly associated (p<0.01). Hypertension and Convulsion and fibrinoid necrosis, syncytial knot and placental infarcts were significantly associated (p<0.001) Premature placenta is associated with cytotrophoblastic layer (p<0.01). Conversely post mature placenta is associated with calcification and infarction.  (p<0.01).  Conclusions: All placentae associated with foetal death have either gross or microscopic abnormalities. Present study is a step towards understanding and extrapolating the already known causes of intrauterine foetal death in the perspective of Jabalpur and its adjoining districts.
Clinical profile of ACS patients and their outcome at tertiary centre in north-eastern Uttar Pradesh, India
Authors: Sarkari M. , Singh Ajeet P.
Published: March 2018

Background: Coronary artery disease (CAD) is a major cause of death in India. This study determined the characteristics, treatment and outcomes of acute coronary syndrome (ACS) at tertiary centre in north eastern Uttar Pradesh in India.Methods: We carried out observational study with 60-days follow-up of 80 ACS patients. Data are collected on different variables including Blood pressure, pulserate, BNP, TROP I, CKMB, patient’s demography, risk factors, laboratory values at admission and repeated as and when required.  Results: T In our study most common presentation was chest pain, majority of patients presented after 12 hour of onset of symptoms, elevation of TROP I was higher in STEMI than NSTEMI, most common complication in NSTEMI was recurrent angina and in STEMI patients was heart failure, total 15 patients expired during study 11 during hospitalization and 4 patients within 60days of follow up, thrombolysed patients has less chances of  regional wall motion abnormality.Conclusions: In our study elevation of TROP I was more in STEMI and there was less chances of RWMA in thrombolysed patients.
Обоснование стратегии реализации программы энергосбережения
Authors: Хусаинов Зуфар Ханифович
Published: March 2018

В статье представлены методы формирования вариантов программы энергосбережения промышленного предприятия, исследованы факторы, оказывающие влияние на параметры программы энергосбережения, дана их качественная и количественная оценка, проведены вариантные расчеты оценки эффективности программы энергосбережения, обоснован выбор наиболее привлекательного варианта.
Модель контракта жизненного цикла в проектах государственно-частного партнерства в сфере физической культуры и спорта
Authors: Савченко Яна Валерьевна , Михайлова Наталия Сергеевна
Published: March 2018

В статье сделан анализ распространенных в настоящий момент в России социальных инфраструктурных проектов на примере сферы физкультуры и спорта по формам, уровням и срокам реализации. Рассмотрены используемые в зарубежной практике формы и модели ГЧП (государственно-частного партнерства) в проектах сферы физической культуры и спорта. Представлена альтернативная модель взаимодействия бизнеса и власти в проектах государственно-частного партнерства, разработанная в рамках контракта жизненного цикла и адаптированная для сферы физкультуры и спорта в России. Проведено сравнение преимуществ и недостатков модели в рамках контракта жизненного цикла и наиболее распространенной модели взаимодействия бизнеса и власти в социальных инфраструктурных проектах – концессионного соглашения. Рассмотрены основные преимущества и экономические выгоды государства и частного партнера от использования контракта жизненного цикла при реализации проекта по строительству объекта в сфере физической культуры и спорта.
Повышение эффективности подготовки и использования управленческой отчетности как фактор эффективности деятельности вуза
Authors: Степанова Анна Вадимовна , Гущина Юлия Игоревна , Старовойтов Михаил Карпович
Published: March 2018

В настоящей статье рассматривается содержательная сторона процесса управления, выраженная в управленческой документации вуза, что особенно актуально в условиях разноплановости и многочисленности отчетной документации.
Подчеркивается актуальность повышения эффективности подготовки и использования управленческой отчетности, учитывая, что она, с одной стороны, позволяет проводить эффективный контроль и надзор за деятельностью вуза, с другой, обеспечить информационную открытость и доступность получаемых сведений.
В работе дается авторское определение управленческой отчетности. Авторами сделана попытка сформулировать цель, задачи, и требования, предъявляемые к управленческой отчетности, предложено дополнить ее классификацию, выделены категории пользователей управленческой документации вуза, а также даны практические рекомендации по формированию эффективной системы управленческой отчетности.
Оценка кооперационно-сетевых взаимодействий через системный подход
Authors: Ананина Римма Фанавиевна , Куимов Василий Васильевич
Published: March 2018

В статье представлено исследование кооперационно-сетевых взаимодействий по виду «совместные покупки» через системный подход, который заключается в выявлении причин, обуславливающих величину различных параметров и их влияние на весь процесс взаимодействия.
Выявление потребности ребрендинга компании индустрии развлечений и постановка проблемы
Authors: Жук Екатерина Сергеевна , Тасина Екатерина Данииловна
Published: March 2018

В современных условиях перенасыщенности отраслевых рынков России товарами и услугами основным методом обеспечения конкурентоспособности компании выступает применение стратегии дифференциации, основным инструментом которой является брендинг. Понимание предпринимателями данной ситуации привело к сущностному изменению взглядов на брендинг, осознанию необходимости пересмотра брендов, проведения ребрендинга, что обеспечивает возможность компаниям укрепить свои позиции на рынке. Статья посвящена проблеме анализа текущего состояния бренда компании, ошибок в его позиционировании. Предложена методика выявления причин несостоятельности бренда, неверного позиционирования и определения проблемы необходимости проведения ребрендинга компании в сфере развлекательных услуг.
Антимонопольное регулирование как средство реализации потенциала импортозамещения Волгоградской области
Authors: Федоричева Анна Сергеевна
Published: March 2018

Импортозамещение в сфере антимонопольного регулирования, выступает как законодательно обоснованное ограничение конкуренции иностранных товаров на внутреннем рынке. В существующей контрактной системе можно выделить ряд направлений по стимулированию импортозамещения: ограничение импорта определенного вида товаров или услуг; преференции при рассмотрении заявок на участие в закупке отечественным производителям; абсолютный запрет на импорт установленной продукции. Система государственных закупок может стать основным средством реализации потенциала импортозамещения в регионе, поскольку призвана сформировать первоначальный спрос и помочь отечественным производителям перейти в стадию выхода на конкурентные объемы производства.
Современные особенности развития межбюджетных трансфертов в Российской Федерации
Authors: Холодова Ольга Анатольевна
Published: March 2018

Настоящая бюджетная политика Российской Федерации вынуждена развиваться в качественно новых экономических условиях. Наличие серьезных противоречий между федерацией и регионами, а также исследователями в данной области по принятым и запланированным изменениям в отдельных отраслях межбюджетных отношений создают необходимость для комплексной оценки существующих поправок и их соизмерения с выявленными проблемами в бюджетной политике. Дополнительную сложность в запланированном анализе добавляет ежегодное изменение в правилах предоставления всех типов межбюджетных трансфертов.
В ходе проведения исследования была поставлена следующая гипотеза: существующая государственная политика в области межбюджетных отношений и межбюджетных трансфертов в частности не содействует развитию самостоятельности работы субъектов РФ и их финансовой независимости от федерации. Результатом работы стало подтверждение поставленной гипотезы.
В будущей модели развития межбюджетной политики в России возможно придется качественно поменять стратегию реализации, в случае, если существующая концепция не позволит решить вопрос постоянного роста долговых обязательств регионов.
Цифровая экономика и ее влияние на конкурентоспособность предпринимательских структур
Authors: Бабкин Александр Васильевич , Чистякова Ольга Владимировна
Published: March 2018

Современная экономика является постиндустриальной, при этом ее часто называют новой, инновационной, экономикой знаний, компетенций, сетевого взаимодействия. Начало XXI века принесло развитие цифровых технологий на основе информационной революции и процессов глобализации экономики. Информация в обществе и процессах хозяйствования стала основным ресурсом. В руках человека она преобразуется в знания, а социально-экономические отношения все больше переносятся в сетевое пространство. Ключевым фактором цифровой трансформации в деятельности субъектов предпринимательства становится развитие цифровой культуры. На современном этапе институциональная структура трансформационного общества имеет свои особенности и требует формирования цифровой экономики, что, в свою очередь, обуславливает необходимость цифровизации предпринимательских структур.
Повышение конкурентоспособности предпринимательских структур на внутреннем и внешнем рынках сопряжены с переходом на инновационную модель экономического развития, предполагающую высокую концентрацию наукоемкого производства, знаний, компетенций, технологий. Вместе с тем, сложившийся в настоящее время уровень инновационного развития предпринимательского сектора России не в полной мере отвечает ожиданиям, связанным с формированием новой экономики инновационного типа.
В данной ситуации, как показывает зарубежный и российский опыт экономической деятельности, цифровизация хозяйствующих субъектов становится тем необходимым инструментом, который может стимулировать восприимчивость предпринимательских структур к нововведениям, а также повысить их инновационную активность в целом. Авторами статьи показаны сущность и особенности цифровой экономики, которую они рассматривают в трех аспектах. Представлены проблемы и тенденции цифровизации как экономики в целом, так и предпринимательских структур, в частности. Проведен анализ влияния процессов цифровизации на конкурентоспособность предпринимательских структур.
Теоретико-институциональный базис формирования системы государственного управления процессом реиндустриализации экономики: политэкономический анализ
Authors: Макаров Иван Николаевич , Колесников Виктор Викторович , Широкова Ольга Вячеславовна , Кадильникова Лариса Васильевна
Published: March 2018

Работа посвящена анализу возможностей эффективной реиндустриализации отечественной экономики в рамках различных хозяйственных порядков и особенной институциональной структуры государственного управления экономикой. В статье доказывается, что в современных условиях функционирования отечественной экономики, характеризующихся искажением институциональных структур, обеспечивающих равновесие в странах развитой рыночной экономике, для осуществления реиндустриализации необходимо активное вмешательство государства на основе разработанной политики стратегического развития отраслей промышленности.
Статья может быть полезна для аспирантов и ученых-политэкономов, специалистов по теории управления, а также руководителей отраслей промышленности и регионов.
Методические подходы к оценке туристско-рекреационного потенциала российских регионов
Authors: Кулакова Людмила Ивановна , Осипов Виктор Алексеевич
Published: March 2018

В настоящей статье рассматривается методика оценки туристско-рекреационного потенциала, разработанная на основе методов корреляционно-регрессионного анализа, содержащая факторы и критерии, определяющие потенциально привлекательные для осуществления предпринимательской деятельности туристские территории. Сформирована покомпонентная и интегральная оценка ключевых факторов, влияющих на развитие территории.
Инновационные решения в торговле в контексте глобальных экономических процессов
Authors: Зверева Анна Олеговна , Ильяшенко Светлана Борисовна
Published: March 2018

Глобальная макроэкономическая ситуация, характерная для современной экономики, во многом сформировалась под воздействием экономического кризиса 2014-2015 гг. Российская экономика также подверглась влиянию глобальных негативных процессов. Снижение предпринимательской активности, падение платежеспособного спроса – основные факторы, которые предопределяют необходимость использования инновационных инструментов и современных технологий для предприятий всех отраслей, в том числе и сферы обращения. Поскольку торговые организации являются конечным звеном в системе распределения, представляется важным применение инновационных подходов, которые обеспечивают их стабильное функционирование. Специфика хозяйственной деятельности торговых структур обуславливает, что большинство инновационных решений в отрасли основано на использовании инструментов электронной среды и интернет-технологий. Их спектр разнообразен и позволяет субъектам отрасли выполнять свои задачи в современных условиях.
Структура товарных ресурсов российской федерации как основа формирования базового ассортимента торговли
Authors: Красильникова Елена Анатольевна , Брагин Леонид Александрович
Published: March 2018

В статье оценивается структура товарных ресурсов РФ с учетом динамики последних лет с проекцией на базовый ассортимент торговых организаций. Авторами исследуются такие макроэкономические показатели, как экспорт, импорт, сальдо внешнеторгового оборота РФ за последние два года. Строится и подтверждается гипотеза о том, что структура товарных ресурсов страны является основой для формирования ассортимента торговых организаций.
Дифференциация подходов к оценке удовлетворенности потребителя качеством торгового обслуживания и механизмы его поддержания
Authors: Урясьева Татьяна Ивановна , Калугина Светлана Афанасьевна , Чеглов Вячеслав Петрович
Published: March 2018

Индекс потребительской удовлетворенности относится к числу стратегических индикаторов, на основе которых торговое предприятие может прогнозировать изменение своей рыночной позиции. Объективная оценка этого показателя требует проведения полномасштабных рыночных исследований, что связано с высокими затратами ресурсов торгового предприятия, что не всегда оправдано. В ряде случаев торговые предприятия могут определить снижение уровня удовлетворенности потребителя на основе «опережающих индикаторов». В зависимости от значения опережающих индикаторов можно обосновать выбор методов проведения исследований, которые потребуют значительно меньших затрат ресурсов, связанных с их проведением. Для оценки потребительской удовлетворенности выделены: стратегический и тактический подходы; обоснован выбор методов проведения такой оценки в зависимости от значения ключевых маркетинговых индикаторов; рассмотрены механизмы поддержания потребительской удовлетворенности и лояльности, используемые в различных видах промоакций.
Нейротехнологии визуального мерчандайзинга в розничной торговле
Authors: Панасенко Светлана Викторовна , Рамазанов Ибрагим Агаевич
Published: March 2018

Глобализация рынков и развитие новых коммуникационных технологий сопровождается не только усилением конкуренции между транснациональными и отечественными торговыми сетями, но и падением результативности классических подходов к продвижению и продаже товаров, что обусловливает необходимость поиска новых способов повышения эффективности ра-боты. В статье оценивается потенциал фундаментальных открытий в меж-дисциплинарных областях науки для развития концепции мерчандайзинга как одной из эффективных технологий продвижения и продажи товаров. Опираясь на открытия нейробиологии, нейроэкономики, нейромаркетинга, когнитивной психологии предлагается использовать способность цвета товара оказывать влияние на нейронную систему человека, силу эмоционально-чувственного возбуждения и направление познавательных ресурсов посетителей торгового зала в визуальном мерчандайзинге. В частности, предлагаются нейровизуальная матрица распределения пространства прилавка, цветовые планограммы выкладки товаров и объемные голограммы дополненной реальности.