bluuebunny/crossref_metadata_2025 huggingface dataset:
A new species of Endustomus Brême, 1842 and new records of Afrotropical Cossyphini Latreille, 1802 (Coleoptera: Tenebrionidae)
Authors: MATSUMOTO KEITA , HÁVA JIŘÍ
Published: August 2021

Endustomus sanjensis sp. nov. is described from Tanzania. First records of Endustomus nimbaensis Ardoin, 1963 and Cossyphus (Cossyphus) moniliferus moniliferus Chevrolat, 1829 are given for Sierra Leone. New faunistic data are provided for E. parallelogrammus parallelogrammus Fairmaire, 1888, E. senegalensis Laporte de Castelnau, 1833, and E. magnicollis Fairmaire, 1887.
Ambivalent perceptions of the Other: Towards a dual-process sociology of intercultural relations
Authors: Høy-Petersen Nina
Published: August 2021

Applying theories from sociology and social psychology concerned with the intersection of culture and cognition to in-depth interviews, this paper empirically explores the Norwegian majority population’s perceptions of cultural diversities using a dual-process (DP) methodological and analytic approach. Globalization has produced a mix of new anxieties, opportunities, and curiosities, leaving most people juggling conflicting objectives of self-preservation and self-realization, and making cognitive self-regulation and behavioural flexibility valorized skills of contemporary life. Instead of identifying xenophobic and cosmopolitan attitudes at opposite ends of a spectrum, the current paper argues in line with current research and theory in studies of DP cognition that they commonly co-exist, albeit in separate automatic and discursive cognitive systems, within the same individual. As a result, people’s perceptions of cultural and ethnic diversities tend to be ambivalent and contextually malleable – for example, in cases where their deep dispositions appear incompatible with their own self-concept or dominant cultural expectations. Most centrally, the current research proposes concrete strategies to elicit responses from both cognitive systems in the context of interpretive interviews. Secondly, the paper proposes clues that help to identify from which cognitive system interviewees’ conflicting cosmopolitan and xenophobic attitudes originate, thereby enabling researchers to further delineate the specific characteristics of these attitudes, including the mode of cultural learning through which they form, their flexibility or robustness to change, their role in behaviour motivation, and the extent to which they are conscious and controllable.
Characteristics, Management, and Prognosis of Spontaneous Coronary Intramural Hematoma
Authors: Chang Shufu , Dai Yuxiang , Song Xiaoyue , Li Chenguang , Lu Hao , Huang Zheyong , Ma Jianying , Qian Juying , Ge Junbo
Published: August 2021

Spontaneous coronary intramural hematoma (SCIH) was one type of spontaneous coronary artery dissection without obvious intimal tear, which is easy to misdiagnose. We aimed to study the characteristics, management, and prognosis of SCIH in our center. All the SCIH patients (n = 30) diagnosed by coronary angiography from January 1, 2012 to December 31, 2018 were enrolled. The demographic characteristics, history, therapy, and follow-up were collected. The mean age of the patients was 51.8 ± 9.5 years. Most of the patients were females (66.7%) with hypertension. Patients with diffuse lesion, focal lesion, and multiple vessels were 70%, 13.3%, and 16.7%, respectively. Conservative treatment was the first choice (76.7%). The mean follow-up time was 29.3 ± 13.5 months. None of the patients had unplanned readmission due to worsening symptoms. Nine patients underwent coronary artery computed tomography reexamination after 10.3 ± 7.5 months, which showed complete recovery of SCIH. Eight patients were hospitalized for coronary angiography 6.4 ± 4.7 months later, which did not show any sign of SCIH. Spontaneous coronary intramural hematoma was most common in post-menopausal women with hypertension. Possibly, antiplatelet drugs should be avoided in SCIH. Waiting for the hematoma to heal was preferable and had a good prognosis.
Therapeutic Dynamics of Aggression, Readiness to Change, and Recidivism in a Partner Violent Men Typology
Authors: Redondo Natalia , Muñoz-Rivas Marina J. , Cantos Arthur L. , Graña Jose Luis
Published: August 2021

The Transtheoretical Model (TTM) of behavior change predicts that patients go through different stages of change prior to changing their problematic behavior. This study aims to evaluate the utility and validity of this model in a sample of 549 court-ordered partner violent men. Three types of perpetrators with respect to their readiness to change were revealed. Those in more advantage stage of change use more processes to change their problem and present with higher levels of intimate partner violence (IPV). Low readiness to change levels and treatment drop-out predict short-term criminal justice recidivism, while treatment drop-out predicts medium and long-term recidivism. Results highlight the applicability of the TTM in IPV and its usefulness in designing behavioral interventions with this population.
The Prosody of Two-Syllable Words in French-Speaking Monolingual and Bilingual Children: A Focus on Initial Accent and Final Accent
Authors: Kehoe Margaret
Published: August 2021

This study examined the acoustic characteristics of disyllabic words produced by French-speaking monolingual and bilingual children, aged 2;6 to 6;10, and by adults. Specifically, it investigated the influence of age, bilingualism, and vocabulary on final-to-initial syllable duration ratios and on the presence of initial and final accent. Children and adults took part in a word-naming task in which they produced a controlled set of disyllabic words. Duration and maximum pitch were measured for each syllable of the disyllabic word and these values were inserted into mixed-effects statistical models. Results indicated that children as young as 2;6 obtained final-to-initial syllable duration ratios similar to those of adults. Young children realized accent on the initial syllable more often and accent on the final syllable less often than older children and adults. There was no influence of bilingualism on the duration and pitch characteristics of disyllabic words. Children aged 2;6 with smaller vocabularies produced initial accent more often than children with large vocabularies. Our findings suggest that early word productions are constrained by developmental tendencies favouring falling pitch across an utterance.
Vitamin D deficiency as a predictor of severity in patients with COVID-19 infection
Authors: Teama Mohammed Abd El Monem , Abdelhakam Dina A , Elmohamadi Marwa A , Badr Fatma Mohammed
Published: August 2021

Background:

As an immune modulator, vitamin D has been implicated in the coronavirus disease 2019 (COVID-19) severity. This study aimed to investigate the association between vitamin D levels and the severity of COVID-19 infection.

Methods:

A cross-sectional study, which included 124 patients diagnosed with COVID-19 and were selected from Ain Shams University Hospitals and assigned to two groups; mild and severe COVID-19. All patients underwent detailed history taking, clinical data, and different laboratory investigations as complete blood count, blood urea nitrogen, serum creatinine, liver enzymes, C-reactive protein, D-dimer, ferritin and serum vitamin D concentration. In addition to findings of initial chest computed tomography (CT) were recorded. COVID-19 Reporting and Data System (CO-RADS) and CT chest severity scores (CT SS) were reported.

Results:

In this study of 124 COVID-19-positive individuals, a high prevalence of hypovitaminosis D was found (97.6%). Lower vitamin D levels were significantly associated with more severe COVID-19 cases ( p-value < 0.001), higher blood levels of inflammatory markers including (D-dimer, CRP, and ferritin), a higher CT SS and longer disease duration. Serum vitamin D can be used as a predictor for the severity of COVID-19 infection with a specificity of 96.6%, and sensitivity of 45.5%.

Conclusion:

The high frequency of hypovitaminosis D in severe COVID-19 patients provides further evidence of a potential link to poor prognosis and severity of the disease, so vitamin D deficiency may be a marker of poor prognosis in these patients.
Using Standardized Videos to Examine the Validity of the Shared Decision Making Process Scale: Results of a Randomized Online Experiment
Authors: Valentine K. D. , Mancini Brittney , Vo Ha , Brodney Suzanne , Cosenza Carol , Barry Michael J. , Sepucha Karen R.
Published: August 2021

Background

The Shared Decision Making (SDM) Process scale is a brief, patient-reported measure of SDM with demonstrated validity in surgical decision making studies. Herein we examine the validity of the scores in assessing SDM for cancer screening and medication decisions through standardized videos of good-quality and poor-quality SDM consultations.

Method

An online sample was randomized to a clinical decision—colon cancer screening or high cholesterol—and a viewing order—good-quality video first or poor-quality video first. Participants watched both videos, completing a survey after each video. Surveys included the SDM Process scale and the 9-item SDM Questionnaire (SDM-Q-9); higher scores indicated greater SDM. Multilevel linear regressions identified if video, order, or their interaction predicted SDM Process scores. To identify how the SDM Process score classified videos, area under the curve (AUC) was calculated. The correlation between SDM Process score and SDM-Q-9 assessed construct validity. Heterogeneity analyses were conducted.

Results

In the sample of 388 participants (68% white, 70% female, average age 45 years) good-quality videos received higher SDM Process scores than poor-quality videos ( Ps < 0.001), and those who viewed the good-quality high cholesterol video first tended to rate the videos higher. SDM Process scores were related to SDM-Q-9 scores ( rs > 0.58; Ps < 0.001). AUC was poor (0.69) for the high cholesterol model and fair (0.79) for the colorectal cancer model. Heterogeneity analyses suggested individual differences were predictive of SDM Process scores.

Conclusion

SDM Process scores showed good evidence of validity in a hypothetical scenario but were lacking in ability to classify good-quality or poor-quality videos accurately. Considerable heterogeneity of scoring existed, suggesting that individual differences played a role in evaluating good- or poor-quality SDM conversations.
Using Artificial Intelligence to Estimate Nonlinear Resilient Modulus Parameters from Common Index Properties
Authors: Camarena Laura
Published: August 2021

The Mechanistic–Empirical Pavement Design Guide (MEPDG) considers a hierarchical approach to determine the input values necessary for most design parameters. Level 1 requires site-specific measurement of the material properties from laboratory testing, whereas other levels make use of equations developed from regression models to estimate the material properties. Resilient modulus is a mechanical property that characterizes the unbound and subgrade materials under loading that is essential for the mechanistic design of pavements. The MEPDG resilient modulus model makes use of a three-parameter constitutive model to characterize the nonlinear behavior of the geomaterials. As the resilient modulus tests are complex, expensive, and require lengthy preparation time, most state highway agencies are unlikely to implement them as routine daily applications. Therefore, it is imperative to make use of models to calculate these nonlinear parameters. Existing models to determine these parameters are frequently based on linear regression. With the development of machine learning techniques, it is feasible to develop simpler equations that can be used to estimate the nonlinear parameters more accurately. This study makes use of the Long-Term Pavement Performance database and machine learning techniques to improve the equations utilized to determine the nonlinear parameters crucial to estimate the resilient modulus of unbound base and subgrade materials.
No Less of a Man: Inducing Empathy to Reduce Male Rape Myth Acceptance
Authors: Patterson Tristan P. , Fiene Sara L. , Cole Brian P.
Published: August 2021

Male sexual assault is an understudied area. Interventions aimed at reducing negative attitudes toward male survivors have received relatively little attention in the field of sexual assault and violence. This may be related to underreported or insufficient data on male survivors or possibly the acceptance of male rape myths. The current research examines the effect of a hypothetical male sexual assault survivor story and empathy writing task on changes in male rape myth acceptance (MRMA) among U.S. men and women ( N = 95). Further, the researchers sought to understand the differences between men and women in MRMA change scores and state emotional empathy for the hypothetical survivor after the empathy induction. Finally, the researchers examined whether state emotional empathy would predict reductions in MRMA and whether participant sex would predict state emotional empathy for the hypothetical survivor after accounting for knowing a male survivor and preinduction MRMA. The results indicated that both men and women experienced significant decreases in MRMA postinduction, and men and women experienced similar levels of change. Additionally, state emotional empathy and preinduction MRMA were the only significant predictors of change scores. Although women reported higher state emotional empathy for the hypothetical survivor, sex was not a significant predictor of state emotional empathy after accounting for personally knowing a male survivor and preinduction MRMA. This research fills a gap in the literature by identifying men’s stories of sexual assault and empathy writing as potential methods to reduce MRMA.
Transitioning Escape Rooms to a Virtual Environment
Authors: Kutzin Jared M. , Sanders Jenny E. , Strother Christopher G.
Published: August 2021

Escape room

games have gained in popularity in both entertainment and education venues over the past several year. The global health pandemic put an abrupt end to in-person escape room programs due to the enclosed space in which they take place. In an attempt to continue to utilize the escape room concept we set about to create a

virtual escape room

using commonly available software and assessed its usability and participant feelings about the experience. The results indicated that the participants thought the escape room was engaging (88%), that they had to work as a team (95%), and that they overall enjoyed the experience (85%). Virtual experiences cannot completely replace in-person experiences, but there are ways to introduce important teamwork and communication concepts to participants and make online meetings and conferences more engaging.
Intimate Partner Violence Stories of Appalachian Women
Authors: Riffe-Snyder Kellie A. , Crist Janice D. , Reel Sally J.
Published: August 2021

The purpose of this study was to explore past intimate partner violence as it occurred in Appalachian women residing in rural and non-urbanized areas. The methodology was qualitative description. Twelve former intimate partner violence female victims shared their experiences through the socioculturally appropriate tradition of story-telling. The meta-theme, Turning Points, reflecting the perceived non-linearity of intimate partner violence was supported by three themes: (1) The Process of Abuse: (2) Learn from my Story; Don’t Let it be Your Story; and (3) Does Where I Live Make a Difference? All participants experienced patterns of abuse that cycled in frequency and severity, similar injuries and health problems, fear, helplessness, and, at times, hopelessness. Application of knowledge gained through naturalistic methods can advance our understanding of intimate partner violence as it occurs in vulnerable populations and the depth and breadth of sociocultural influences which may affect the public health threat of this type of violence.
Qualitative Description and Black Males: On Race, the Body, and Researching the Unimaginable
Authors: Brown Anthony L.
Published: August 2021

In this article, I explore how race and the body are central to social and education research on Black males. The guiding question of this essay is, How has the Black male body been conceptualized over time through qualitative description? I argue that, as Black males entered into new systems of reasoning, the Black male body was examined in different ways. Drawing from Sylvia Wynter’s concept of subjective understanding and David Theo Goldberg’s concept of racial knowledge, I explore the temporal and spatial meaning of qualitative description in the context of African American males. I conclude this essay by arguing for a different approach to qualitative description of Black males that moves beyond recycled stories of deficits or counter-narratives and on to explore the unimaginable.
Initial study of an alternative technology aimed at measuring and controlling the flow rate in air conditioning ducts
Authors: Testi Andrei , Marcelino Marcio Abud , Lotufo Francisco Antonio , de Souza Teófilo Miguel
Published: August 2021

This paper states that there might have around 1000 small size business jets (until nine occupants) flying across the world equipped with flow control and regulating shut-off valves that uses hot wire anemometer devices to regulate massflow rate from the bleed airflow to supply the air-conditioning and pressurization systems. However, these valves present low reliability in the field. The purpose of this paper is to evaluate the implications of a flow control and regulating shut-off valve with a non-intrusive airflow measurer device under the perspective of fluid mechanics. The Venturi technology that is commonly used technology, given its construction simplicity, precision, and broad use in the industry, is selected to substitute the flow control and regulating shut-off valves with hot wire anemometer of the mentioned small size business jets applications. This paper has adopted a numeric simulation approach utilizing the ANSYS-CFX computational fluid dynamics software to verify both the differential pressure at the Venturi device and its correspondent mass flow rate to supply the air conditioning systems of some small size business jets, considering the mass-flow rate as requested by the FAA certification requirement (0.55 lb/min per occupant). This paper shows that a mass-flow rate control and regulating shut-off valve with a Venturi device, of 1 inch and β of 0.67, is compliant with the minimum fresh air flow requested by the FAA certification requirement to operate in some small size business jets. Besides that, the software ANSYS-CFX is also effective to support the engineering analysis of flow field characteristics inherent to the applications of internal compressible flow. The numeric simulation utilizing the ANSYS-CFX computational fluid dynamics software outlined herein can lay the basis for further research related to the design of a flow control and regulating shut-off valves with a Venturi device.
Is the attentional SNARC effect truly attentional? Using temporal order judgements to differentiate attention from response
Authors: Galarraga Diana B , Pratt Jay , Cochrane Brett A
Published: August 2021

The spatial–numerical association of response codes (SNARC) effect reflects the phenomenon that low digits are responded to faster with the left hand and high digits with the right. Recently, a particular variant of the SNARC effect known as the attentional SNARC (which reflects that attention can be shifted in a similar manner) has had notable replicability issues. However, a potentially useful method for measuring it was revealed by Casarotti et al. using a temporal order judgement (TOJ) task. Accordingly, the present study evaluated whether Casarotti et al.’s results were reproducible by presenting a low (1) or high (9) digit prior to a TOJ task where participants had to indicate which of two peripherally presented targets appeared first (Experiment 1) or second (Experiment 2). In Experiment 1, it was revealed that the findings of Casarotti et al.’s were indeed observable upon replication. In Experiment 2, when attention and response dimensions were put in opposition, the SNARC effect corresponded to the side of response rather than attention. Taken together, the present study confirms the robustness of the attentional SNARC in TOJ tasks, but that it is not likely due to shifts in attention.
Rehabilitation Principles to Consider for Anterior Cruciate Ligament Repair
Authors: Wu Jocelyn , Kator Jamie L. , Zarro Michael , Leong Natalie L.
Published: August 2021

Context:

Injury to the anterior cruciate ligament (ACL) is among the most common orthopaedic injuries, and reconstruction of a ruptured ACL is a common orthopaedic procedure. In general, surgical intervention is necessary to restore stability to the injured knee, and to prevent meniscal damage. Along with surgery, intense postoperative physical therapy is needed to restore function to the injured extremity. ACL reconstruction (ACLR) has been the standard of care in recent decades, and advances in surgical technology have reintroduced the prospect of augmented primary repair of the native ACL via a variety of methods.

Evidence Acquisition:

A search of PubMed database of articles and reviews available in English was performed through 2020. The search terms ACLR, anterior cruciate ligament repair, bridge enhanced acl repair, suture anchor repair, dynamic intraligamentary stabilization, internal bracing, suture ligament augmentation, and internal brace ligament augmentation were used.

Study Design:

Clinical review.

Level of Evidence:

Level 5.

Results:

No exact consensus exists on effective rehabilitation protocols after ACL repair techniques, as the variation in published protocols seem even greater than the variation in those for ACLR. For some techniques such as internal bracing and dynamic interligamentary stabilization, it is likely permissible for the patients to progress to full weightbearing and discontinue bracing sooner. However, caution should be applied with regard to earlier return to sport than after ACLR as to minimize risk for retear.

Conclusion:

More research is needed to address how physical therapies must adapt to these innovative repair techniques. Until that is accomplished, we recommend that physical therapists understand the differences among the various ACL surgery techniques discussed here and work with the surgeons to develop a rehabilitation protocol for their mutual patients.

Strength of Recommendation Taxonomy (SORT):

C.
Studying problems, not problematic usage: Do mobile checking habits increase procrastination and decrease well-being?
Authors: Meier Adrian
Published: August 2021

Most prior research on the effects of mobile and social media on well-being has worked from either the “technology addiction” or “screen time” approach. Yet these frameworks struggle with considerable conceptual and methodological limitations. The present study discusses and tests an established but understudied alternative, the technology habit approach. Instead of conflating mobile usage with problems (i.e., addictive/problematic usage) or ignoring users’ psychological engagement with mobiles (i.e., screen time), this approach investigates how person-level (habit strength) and day-level aspects of mobile habits (perceived interruptions and the urge to check) contribute to a key problem outcome, procrastination, as well as affective well-being and meaningfulness. In a five-day diary study with N = 532 student smartphone users providing N = 2,331 diary entries, mobile checking habit strength, perceived interruptions, and the urge to check together explained small to moderate amounts of procrastination. Procrastination, in turn, was linked to lower affective well-being and meaningfulness. Yet mobile habits showed only very small or no direct associations with affective well-being and meaningfulness. By separating habitual mobile connectivity from problem outcomes and well-being measures, this research demonstrates a promising alternative to the study of digital well-being.
Design choices: Mechanism design and platform capitalism
Authors: Viljoen Salomé , Goldenfein Jake , McGuigan Lee
Published: August 2021

Mechanism design is a form of optimization developed in economic theory. It casts economists as institutional engineers, choosing an outcome and then arranging a set of market rules and conditions to achieve it. The toolkit from mechanism design is widely used in economics, policymaking, and now in building and managing online environments. Mechanism design has become one of the most pervasive yet inconspicuous influences on the digital mediation of social life. Its optimizing schemes structure online advertising markets and other multi-sided platform businesses. Whatever normative rationales mechanism design might draw on in its economic origins, as its influence has grown and its applications have become more computational, we suggest those justifications for using mechanism design to orchestrate and optimize human interaction are losing traction. In this article, we ask what ideological work mechanism design is doing in economics, computer science, and its applications to the governance of digital platforms. Observing mechanism design in action in algorithmic environments, we argue it has become a tool for producing information domination, distributing social costs in ways that benefit designers, and controlling and coordinating participants in multi-sided platforms.
Locking retrograde nail, non-locking retrograde nail and plate fixation in the treatment of distal third femoral shaft fractures: radiographic, bone densitometry and clinical outcomes
Authors: Meccariello Luigi , Bisaccia Michele , Ronga Mario , Falzarano Gabriele , Caraffa Auro , Rinonapoli Giuseppe , Grubor Predrag , Pace Valerio , Rollo Giuseppe
Published: August 2021

Background

Distal third femoral shaft fractures are characterized by increasing incidence and complexity and are still considered a challenging problem (high morbidity and mortality). No consensus on best surgical option has been achieved. This study aims to investigate radiographic, mineral bone densitometry and clinical outcomes of locking retrograde intramedullary (LRN) nailing, non-locking retrograde intramedullary nailing and anatomical locking plate to surgically treat distal third femoral shaft fractures in young adults. Our hypothesis was that there is no significant statistical difference among the surgical options in terms of results (radiographic, bone densitometry and outcomes assessment).

Methods

Retrospective study: 90 patients divided into three groups (group 1 LRN, group 2 NLRN, group 3 plating). Average age was respectively 42.67 (± 18.32), 44.27 (± 15.11) and 42.84 (± 18.32) years. Sex ratio F:M was respectively 2.75, 2.33 and 2.00. AO Classification, KOOS, NUSS and RUSH score, VAS, DEXA scans and plain radiographs were used. Evaluation endpoint: 12 months after surgery.

Results

There were no statistical differences in terms of surgery time, transfusions, and wound healing. Results were similar with regard to average time of bone healing, RUSH scores, VAS, KOOS, regression between RUSH and VAS, average correlation clinical–radiographic results and patients outcomes.

Conclusions

Our results showed no statistical difference in the use of LNR, NLNR and plating for treatment of distal third femur shaft fractures in terms of radiographic, bone densitometry and clinical outcomes. Good subjective and objective results are provided by all three techniques. The choice among the studied techniques must be based on surgeons’ experience, indications and subjective patients’ aspects. The absence of relevant similar data in the published literature does not allow definitive validation (or rejection) of our hypothesis. A more powered study with a bigger cohort is needed for definitive validation.
Anti-inflammatory protein TNFα-stimulated gene-6 (TSG-6) reduces inflammatory response after brain injury in mice
Authors: Mutoji Kazadi Nadine , Sun Mingxia , Nash Amanda , Puri Sudan , Hascall Vincent , Coulson-Thomas Vivien J.
Published: August 2021

Background

Current research suggests that the glial scar surrounding penetrating brain injuries is instrumental in preserving the surrounding uninjured tissue by limiting the inflammatory response to the injury site. We recently showed that tumor necrosis factor (TNF)-stimulated gene-6 (TSG-6), a well-established anti-inflammatory molecule, is present within the glial scar. In the present study we investigated the role of TSG-6 within the glial scar using TSG-6 null and littermate control mice subjected to penetrating brain injuries.

Results

Our findings show that mice lacking TSG-6 present a more severe inflammatory response after injury, which was correlated with an enlarged area of astrogliosis beyond the injury site.

Conclusion

Our data provides evidence that TSG-6 has an anti-inflammatory role within the glial scar.
Perimyocarditis following first dose of the mRNA-1273 SARS-CoV-2 (Moderna) vaccine in a healthy young male: a case report
Authors: Hasnie Ammar A. , Hasnie Usman A. , Patel Nirav , Aziz Muhammad U. , Xie Min , Lloyd Steven G. , Prabhu Sumanth D.
Published: August 2021

Background

Half of U.S. adults have received at least one dose of the COVID-19 vaccines produced by either Pfizer, Moderna, or Johnson and Johnson, which represents a major milestone in the ongoing pandemic. Given the emergency use authorizations for these vaccines, their side effects and safety were assessed over a compressed time period. Hence, ongoing monitoring for vaccine-related adverse events is imperative for a full understanding and delineation of their safety profile.

Case presentation

An 22-year-old Caucasian male presented to our hospital center complaining of pleuritic chest pain. Six months prior he had a mild case of COVID-19, but was otherwise healthy. He had received his first dose of the Moderna vaccine three days prior to developing symptoms. Laboratory analysis revealed a markedly elevated troponin and multiple imaging modalities during his hospitalization found evidence of wall motion abnormalities consistent with a diagnosis of perimyocarditis. He was started on aspirin and colchicine with marked improvement of his symptoms prior to discharge.

Conclusions

We present a case of perimyocarditis that was temporally related to COVID-19 mRNA vaccination in an young male with prior COVID-19 infection but otherwise healthy. Our case report highlights an albeit rare but important adverse event for clinicians to be aware of. It also suggests a possible mechanism for the development of myocardial injury in our patient.
Does Case Management Provide Support for Staff Facing Frequent Users of Emergency Departments? A Comparative Mixed-Method Evaluation of ED Staff Perception
Authors: von Allmen Michael , Grazioli Véronique S. , Kasztura Miriam , Chastonay Oriane , Moullin Joanna C. , Hugli Olivier , Daeppen Jean-Bernard , Bodenmann Patrick
Published: August 2021

Objective

Frequent users of emergency departments (FUED) account for a disproportionate number of emergency department (ED) visits and contribute to a wide range of challenges for ED staff. While several research has documented that case management (CM) tailored to FUED leads to a reduction in ED visits and a better quality of life (QoL) among FUED, whether there is added value for ED staff remains to be explored. This study aimed to compare, among staff in two academic EDs in Switzerland (one with and one without CM), the FUED-related knowledge, perceptions of the extent of the FUED issue, FUED-related work challenges and FUEDs’ legitimacy to use ED.

Method

Mixed methods were employed. First, ED physicians and nurses (N = 253) of the two EDs completed an online survey assessing their knowledge and perceptions of FUEDs. Results between healthcare providers working in an ED with CM to those working in an ED without CM were compared using independent two-sided T-tests. Next, a sample of participants (n = 16) took part in a qualitative assessment via one-to-one interviews (n = 6) or focus groups (n = 10).

Results

Both quantitative and qualitative results documented that the FUED-related knowledge, the extent FUED were perceived as an issue and perceived FUEDs’ legitimacy to use ED were not different between groups. The level of perceived FUED-related challenges was also similar between groups. Quantitative results showed that nurses with CM experienced more challenges related to FUED. Qualitative exploration revealed that lack of psychiatric staff within the emergency team and lack of communication between ED staff and CM team were some of the explanations behind these counterintuitive findings.

Conclusion

Despite promising results on FUEDs’ QoL and frequency of ED visits, these preliminary findings suggest that CM may provide limited support to ED staff in its current form. Given the high burden of FUED-related challenges encountered by ED staff, improved communication and FUED-related knowledge transfer between ED staff and the CM team should be prioritized to increase the value of a FUED CM intervention for ED staff.
Supplemental bifid triple viable capsule treatment improves inflammatory response and T cell frequency in ulcerative colitis patients
Authors: Li Shuying , Yin Yan , Xiao Dan , Zou Yong
Published: August 2021

Background

Ulcerative colitis is a common non-specific chronic disease. Supplementing probiotics has become an important method for the treatment of ulcerative colitis. This study aimed to explore the effect of supplementing bifid triple viable capsules on background mesalazine plus somatostatin on plasma inflammatory factors and T cell frequency in ulcerative colitis patients.

Methods

A total of 130 ulcerative colitis patients admitted to our hospital from August 2018 to March 2020 were included and divided into the experimental group (65 patients with mesalazine plus somatostatin and bifid triple viable capsules for treatment) and the control group (65 patients treated with mesalazine plus somatostatin) using the random number table method. Bifid triple viable bacteria capsules were given orally, 420 mg each time, with 3 times a day for 2 months.

Results

Before treatment, the plasma levels of IL-6, IL-8, hs-CRP, TNF-α, D-lactic acid, and endotoxin (ET), CD4+, CD8+, CD4/CD8 ratio, diamine oxidase (DA0), emotional ability, social ability, intestinal and systemic symptoms were not significantly different between the two groups (all P > 0.05). After treatment, the plasma levels of IL-6, IL-8, hs-CRP, and TNF-α decreased in both groups, and were lower in the experimental group than those in the control group (all P < 0.05). The levels of CD4+ and CD4/CD8 ratio increased, and were higher in the experimental group than those in the control group (P < 0.05); the CD8+ levels were reduced, and were lower in the experimental group than those in the control group (P < 0.05). The plasma D-lactic acid, ET, and DA0 levels were decreased, and were lower in the experimental group than those in the control group; emotional ability, social ability, intestinal and systemic symptoms were improved, and were higher in the experimental group than those in the control group (all P < 0.05). During the course of treatment, 2 cases of abdominal discomfort and 1 case of rash occurred in the experimental group, with an adverse event rate of 4.62% (3/65); 3 cases of abdominal discomfort and 2 cases of rash occurred in the control group, with an adverse event rate of 7.69% (5/65).

Conclusion

The supplementary treatment of bifid triple viable capsules can effectively enhance the curative effect in ulcerative colitis patients, reduce plasma inflammatory factors, and regulate T cell frequency, which is worthy of clinical application.
Longitudinal measurement invariance of the patient health questionnaire in a German sample
Authors: Moehring Anne , Guertler Diana , Krause Kristian , Bischof Gallus , Rumpf Hans-Juergen , Batra Anil , Wurm Susanne , John Ulrich , Meyer Christian
Published: August 2021

Background

The Patient Health Questionnaire-8 (PHQ-8) is a screening questionnaire of depressive symptoms. However, it is unknown whether it is equivalent across time and between groups of individuals. The aim of our paper was to test whether the PHQ-8 has the same meaning in two groups of individuals over time.

Methods

Primary care patients were proactively recruited from three German cities. PHQ-8 data from a baseline assessment (n = 588), two assessments during the intervention (n = 246/225), and a six (n = 437) and 12 months (n = 447) follow-up assessment were first used to examine the factor structure of the PHQ-8 by confirmatory factor analysis (CFA). The best fitting factor solution was then used to test longitudinal invariance across time and between intervention and control group by Multiple Group CFA.

Results

A two-factor structure consistently showed the best model fit. Only configural longitudinal invariance was evidenced when the baseline assessment was included in the analysis. Without the baseline assessment, strict longitudinal invariance was shown across the intervention and the follow-up assessments. Scalar invariance was established between the intervention and control group for the baseline assessment and strict invariance between groups and across the 6- and 12-month follow-up assessments.

Conclusions

The lack of longitudinal invariance might be attributed to various differences between the baseline assessments and all following assessments, e.g., assessment mode (iPad vs telephone), potential changes in symptom perception, and setting.

Trial registration

DRKS00011635, date of trial registration: 20.01.2017; DRKS00011637, date of trial registration: 25.01.2017.
Immediate and 6-week effects of wearing a knee sleeve following anterior cruciate ligament reconstruction: a cross-over laboratory and randomised clinical trial
Authors: Sole Gisela , Lamb Peter , Pataky Todd , Klima Stefan , Navarre Pierre , Hammer Niels
Published: August 2021

Background

Rehabilitation following anterior cruciate ligament (ACL) reconstructions is based mainly on comprehensive progressive exercise programmes using a multi-dimensional approach. Elastic knee sleeves may be useful adjuncts to rehabilitation. The aim of this study was to determine the immediate and 6-week effects of wearing a knee sleeve on person-reported outcomes and function in participants who had undergone an ACL reconstruction and who had residual self-reported functional limitations.

Methods

Individuals with ACL reconstruction in the previous 6 months to 5 years were recruited. Immediate effects of a commercially-available elastic knee sleeve on single-leg horizontal hop distance were explored using a cross-over design. Following this first session, participants were randomised into a Control Group and a Sleeve Group who wore the sleeve for 6 weeks, at least 1 h daily. Outcome measures for the randomised clinical trial (RCT) were the International Knee Documentation Classification Subjective Knee Form (IKDC-SKF) score, the single-leg horizontal hop distance, and isokinetic quadriceps and hamstring peak torque. Linear mixed models were used to determine random effects. Where both limbs were measured at multiple time points, a random measurement occasion effect nested within participant was used.

Results

Thirty-four individuals (16 women) with ACL reconstruction completed the cross-over trial. Hop distance for the injured side during the sleeve condition increased by 3.6 % (95 % CI 0.4–6.8 %,p = 0.025). There was no evidence of differential changes between groups for the IKDC-SKF (Sleeve Groupn = 15; Control Groupn = 16;p = 0.327), or relative improvement in the injured side compared to the uninjured side for the physical performance measures (Sleeve Groupn = 12, Control Groupn = 12; three-way interactionp = 0.533 [hop distance], 0.381 [quadriceps isokinetic peak torque], and 0.592 [hamstring isokinetic peak torque]).

Conclusions

Single-leg hop distance of the ACL reconstructed side improved when wearing a knee sleeve. Wearing the knee sleeve over 6 weeks did not lead to enhanced improvements in self-reported knee function, hop distance and thigh muscle strength compared to the control group.

Trial registration

The trial was prospectively registered with the Australia New Zealand Clinical Trials Registry No:ACTRN12618001083280, 28 June 2018.
Endogenous estrogen exposure and chronic kidney disease; a 15-year prospective cohort study
Authors: Farahmand Maryam , Ramezani Tehrani Fahimeh , Khalili Davood , Cheraghi Leila , Azizi Fereidoun
Published: August 2021

Background

Despite strong evidence demonstrating the role of estrogen as a protective factor for kidney function in women, limited data are available regarding the influence of endogenous estrogen exposure (EEE) on chronic kidney disease (CKD). The present study aimed to assess the incidence of CKD in women with various levels of EEE.

Methods

In a prospective population-based study over a 15-year follow-up, a total of 3043 eligible women aged 30–70 years, participating in Tehran-Lipid and Glucose-Study were recruited and divided into two groups (EEE < 11 and EEE ≥ 11 years). EEE calculated based on age at menarche, age at menopause, number and duration of pregnancies, lactation, and duration of oral contraceptive use after excluding the progesterone dominant phase of the menstrual cycle. Cox’s proportional hazards model was applied to estimate the hazard ratio of CKD between the study groups, after adjusting for confounders.

Results

The total cumulative incidence rate of CKD was 50.1 per 1000 person years; 95% CI: 47.7–52.6); this was 53.9 (95%CI, 50.2–57.8) and 47.1 (95%CI, 44.0–50.4) per 1000 person years in women with EEE < 11 and EEE ≥ 11 years, respectively. The model adjusted for age, BMI, smoking, hypertension, and diabetes showed that the hazard ratio (HR) of incidence CKD in women with EEE < 11 compare to those with EEE ≥ 11 years in the subgroup of women aged< 45 years was 2.66(95% CI, 2.2, 3.2), whereas, in the subgroup aged ≥45 years, it was 1.22 (95% CI, 1.04, 1.4).

Conclusion

This study shows a higher HR of CKD incidence in women with low EEE levels in their later life. Screening of these women for CKD may be recommended.
Role of obesity and hypertension in the incidence of atrial fibrillation, ischaemic heart disease and heart failure in patients with diabetes
Authors: Sala Lucia La , Pontiroli Antonio E.
Published: August 2021

In a cohort study performed using primary care databases in a General Practitioners Network, Groenewegen et al. report a clear association between diabetes and incidence of the major chronic progressive heart diseases, notably heart failure (Groenewegen et al. in Cardiovasc Diabetol 20:123, 2021). However, no mention is made of body mass index and hypertension in the methods or in the results. Obesity is linked to hypertension and hypertension is a major risk factor for all cardiovascular diseases, and prospective studies have shown that obesity and hypertension contribute significantly to atrial fibrillation in persons with diabetes. The data would be improved by assessing the role of obesity and of hypertension in the incidence of heart diseases in these patients. This would also lead to a better and personalized treatment of patients with diabetes, for instance through weight loss and intensification of treatment of hypertension, to modify the incidence of atrial fibrillation, ischaemic heart disease and heart failure.
Alterations in complex lipids in tumor tissue of patients with colorectal cancer
Authors: Pakiet Alicja , Sikora Kinga , Kobiela Jarek , Rostkowska Olga , Mika Adriana , Sledzinski Tomasz
Published: August 2021

Background

Accumulating evidence indicates alterations in lipid metabolism and lipid composition in neoplastic tissue. Earlier nuclear magnetic resonance studies showed that the contents of major lipid groups, such as triacylglycerols, phospholipids and cholesterol, are changed in colon cancer tissue.

Methods

In this study, a more detailed analysis of lipids in cancer and tumor adjacent tissues from colorectal cancer patients, using liquid chromatography–mass spectrometry, allowed for comparison of 199 different lipids between cancer tissue and tumor adjacent tissue using principal component analysis.

Results

Significant differences were found in 67 lipid compounds between the two types of tissue; many of these lipid compounds are bioactive lipids such as ceramides, lysophospholipids or sterols and can influence the development of cancer. Additionally, increased levels of phospholipids and sphingolipids were present, which are major components of the cell membrane, and increases in these lipids can lead to changes in cell membrane properties.

Conclusions

This study showed that many complex lipids are significantly increased or decreased in colon cancer tissue, reflecting significant alterations in lipid metabolism. This knowledge can be used for the selection of potential molecular targets of novel anticancer strategies based on the modulation of lipid metabolism and the composition of the cell membrane in colorectal cancer cells.
Platelet membrane-camouflaged silver metal-organic framework drug system against infections caused by methicillin-resistant Staphylococcus aureus
Authors: Huang Rong , Cai Guang-Qing , Li Jian , Li Xi-Sheng , Liu Hai-Ting , Shang Xue-Ling , Zhou Jian-Dang , Nie Xin-Min , Gui Rong
Published: August 2021

Background

Due to the intelligent survival strategy and self-preservation of methicillin-resistantStaphylococcus aureus(MRSA), many antibiotics are ineffective in treating MRSA infections. Nano-drug delivery systems have emerged as a new method to overcome this barrier. The aim of this study was to construct a novel nano-drug delivery system for the treatment of MRSA infection, and to evaluate the therapeutic effect and biotoxicity of this system. We prepared a nano silver metal-organic framework using 2-methylimidazole as ligand and silver nitrate as ion provider. Vancomycin (Vanc) was loaded with Ag-MOF, and nano-sized platelet vesicles were prepared to encapsulate Ag-MOF-Vanc, thus forming the novel platelet membrane-camouflaged nanoparticles PLT@Ag-MOF-Vanc.

Results

The synthesized Ag-MOF particles had uniform size and shape of radiating corona. The mean nanoparticle size and zeta potential of PLT@Ag-MOF-Vanc were 148 nm and − 25.6 mV, respectively. The encapsulation efficiency (EE) and loading efficiency (LE) of vancomycin were 81.0 and 64.7 %, respectively. PLT@Ag-MOF-Vanc was shown to be a pH-responsive nano-drug delivery system with good biocompatibility. Ag-MOF had a good inhibitory effect on the growth of three common clinical strains (Escherichia coli,Pseudomonas aeruginosa, andS. aureus). PLT@Ag-MOF-Vanc showed better antibacterial activity against common clinical strains in vitro than free vancomycin. PLT@Ag-MOF-Vanc killed MRSA through multiple approaches, including interfering with the metabolism of bacteria, catalyzing reactive oxygen species production, destroying the integrity of cell membrane, and inhibiting biofilm formation. Due to the encapsulation of the platelet membrane, PLT@Ag-MOF-Vanc can bind to the surface of the MRSA bacteria and the sites of MRSA infection. PLT@Ag-MOF-Vanc had a good anti-infective effect in mouse MRSA pneumonia model, which was significantly superior to free vancomycin, and has no obvious toxicity.

Conclusions

PLT@Ag-MOF-Vanc is a novel effective targeted drug delivery system, which is expected to be used safely in anti-infective therapy of MRSA.

Graphic abstract