bluuebunny/crossref_metadata_2025 huggingface dataset:
The Ethical Mandate of unesco
Authors: Molnár-Gábor Fruzsina
Published: November 2020

Complying with the statutory mission of promoting collaboration in science the United Nations Educational, Scientific and Cultural Organization (unesco) perceives an ethical mandate which commenced in the 1970s and has been object of ongoing establishment regarding its integration into the human rights framework and its institutionalization ever since. The main achievements within this mandate are so far unesco’s standard-setting activities, among which the most important are three universal declarations, and its field work based on different ethical projects which aim at expanding capacities, coordination and the international cooperation within bioethics. As for the ethical achievements in 2014, these are basically rooted in the Medium-term Strategy 2014–2021 and manifested in the working program of International Bioethics Committee (ibc) for 2014–2015. They were discussed in and already partly realized through the Joint Session of the ibc and the Intergovernmental Bioethics Committee and the meetings of the 21st Session of the ibc. Together with unesco’s field work in 2014, the progress is important regarding the role of ethics within the human rights framework; the cooperation between unesco’s bioethical committees; the involvement of organizations in the work of unesco; and its future standard-setting activities.
Arne Grøn’s Existential Hermeneutics: Existence, Ethics and Religion
Authors: Stigel Hansen Bjarke Mørkøre , Peter Karlsen Mads , Rosfort René
Published: November 2020

This paper presents an introduction to Arne Grøn’s existential hermeneutics as a philosophical method, while also attempting to indicate how Grøn’s work contributes to and engages in a number of crucial topics in modern continental philosophy. The first section of the paper shows how Grøn draws on Paul Ricoeur and Michael Theunissen to rethink the concept of existence through a reading of Kierkegaard that uncouples this concept from the self-evident status it attained in twenty-century existentialism. The second section of the paper argues that Grøn proposes an existential ethics that takes the Kierkegaardian notion that humans are inherently normative beings and uses this as a basis for a critique of ethics, as well as for establishing an ethics of vision inspired by Kierkegaard. The third section of the paper presents a reading of Grøn’s notion of religion as an inextricable part of human existence.
To be or not to be tchernovi: a taxonomic revision of the snake genus Micrelaps (Squamata: Serpentes), in Israel
Authors: JAMISON SIMON , MAZA EREZ , SINAIKO GUY , TAMAR KARIN , SLAVENKO ALEX , MEIRI SHAI
Published: November 2020

The enigmatic snake genus Micrelaps has uncertain phylogenetic affinities. The type species of the genus, Micrelaps muelleri, inhabits the Southern Levant. Snakes inhabiting the Jordan River Valley just south of the Sea of Galilee have been described as a new species, Micrelaps tchernovi, based on their distinct colour patterns, despite M. muelleri being well known to be variable in colour-pattern traits. Here we use morphological and molecular data to examine the taxonomic status and phylogenetic affinity of Levantine Micrelaps. We show that all scalation, colour, and pattern-related traits are extremely variable across the range of these snakes. Some morphological features show clinal variation related to temperature and precipitation, and snakes with a ‘tchernovi’ morph are merely at one end of a continuum of morphological variation. Both ‘classical muelleri’ and ‘tchernovi’ morphs occur in syntopy in the Jordan Valley and elsewhere in Israel. Against this background of high morphological variation, neutral genetic markers show almost no differentiation between snakes, no genetic structure is evident across populations, and no differences are to be found between the two putative species. We conclude that Levantine Micrelaps belongs to a single, morphologically variable, and genetically uniform species, Micrelaps muelleri, of which M. tchernovi is a junior synonym.
The Role of Curvature in Modifying Frontal Instabilities. Part I: Review of Theory and Presentation of a Nondimensional Instability Criterion
Authors: Buckingham Christian E. , Gula Jonathan , Carton Xavier
Published: November 2020

In this study, we examine the role of curvature in modifying frontal stability. We first evaluate the classical criterion that the Coriolis parameter f multiplied by the Ertel potential vorticity (PV) q is positive for stable flow and that instability is possible when this quantity is negative. The first portion of this statement can be deduced from Ertel’s PV theorem, assuming an initially positive fq. Moreover, the full statement is implicit in the governing equation for the mean geostrophic flow, as the discriminant, fq, changes sign. However, for curved fronts in cyclogeostrophic or gradient wind balance (GWB), an additional term enters the discriminant owing to conservation of absolute angular momentum L. The resulting expression, (1 + Cu)fq < 0 or Lq < 0, where Cu is a nondimensional number quantifying the curvature of the flow, simultaneously generalizes Rayleigh’s criterion by accounting for baroclinicity and Hoskins’s criterion by accounting for centrifugal effects. In particular, changes in the front’s vertical shear and stratification owing to curvature tilt the absolute vorticity vector away from its thermal wind state; in an effort to conserve the product of absolute angular momentum and Ertel PV, this modifies gradient Rossby and Richardson numbers permitted for stable flow. This forms the basis of a nondimensional expression that is valid for inviscid, curved fronts on the f plane, which can be used to classify frontal instabilities. In conclusion, the classical criterion fq < 0 should be replaced by the more general criterion for studies involving gravitational, centrifugal, and symmetric instabilities at curved density fronts. In Part II of the study, we examine interesting outcomes of the criterion applied to low-Richardson-number fronts and vortices in GWB.
Subseasonal Deterministic Prediction Skill of Low-Level Geopotential Height Affecting Southern Africa
Authors: Engelbrecht Christien J. , Phakula Steven , Landman Willem A. , Engelbrecht Francois A.
Published: November 2020

The NCEP CFSv2 and ECMWF hindcasts are used to explore the deterministic subseasonal predictability of the 850-hPa circulation of a large domain over the Atlantic and Indian Oceans that is relevant to the weather and climate of the southern African region. For NCEP CFSv2, 12 years of hindcasts, starting on 1 January 1999 and initialized daily for four ensemble members up to 31 December 2010 are verified against ERA-Interim reanalysis data. For ECMWF, 20 years of hindcasts (1995–2014), initialized once a month for all the months of the year are employed in a parallel analysis to investigate the predictability of the 850-hPa circulation. The ensemble mean for 7-day moving averages is used to assess the prediction skill for all the start dates in each month of the year, with a focus on the start dates in each month that are representative of the week-3 and week-4 hindcasts. The correlation between the anomaly patterns over the study domain shows skill over persistence up into the week-3 hindcasts for some months. The spatial distribution of the correlation between the anomaly patterns show skill over persistence to notably reduce over the domain by week 3. A prominent area where prediction skill survives the longest, occur over central South America and the adjacent Atlantic Ocean.
Exoskeleton Application to Military Manual Handling Tasks
Authors: Proud Jasmine K. , Lai Daniel T. H. , Mudie Kurt L. , Carstairs Greg L. , Billing Daniel C. , Garofolini Alessandro , Begg Rezaul K.
Published: November 2020

Objective

The aim of this review was to determine how exoskeletons could assist Australian Defence Force personnel with manual handling tasks.

Background

Musculoskeletal injuries due to manual handling are physically damaging to personnel and financially costly to the Australian Defence Force. Exoskeletons may minimize injury risk by supporting, augmenting, and/or amplifying the user’s physical abilities. Exoskeletons are therefore of interest in determining how they could support the unique needs of military manual handling personnel.

Method

Industrial and military exoskeleton studies from 1990 to 2019 were identified in the literature. This included 67 unique exoskeletons, for which Information about their current state of development was tabulated.

Results

Exoskeleton support of manual handling tasks is largely through squat/deadlift (lower limb) systems (64%), with the proposed use case for these being load carrying (42%) and 78% of exoskeletons being active. Human–exoskeleton analysis was the most prevalent form of evaluation (68%) with reported reductions in back muscle activation of 15%–54%.

Conclusion

The high frequency of citations of exoskeletons targeting load carrying reflects the need for devices that can support manual handling workers. Exoskeleton evaluation procedures varied across studies making comparisons difficult. The unique considerations for military applications, such as heavy external loads and load asymmetry, suggest that a significant adaptation to current technology or customized military-specific devices would be required for the introduction of exoskeletons into a military setting.

Application

Exoskeletons in the literature and their potential to be adapted for application to military manual handling tasks are presented.
Constructing the Electric Eye: Situating the Smithsonian National Air and Space Museum’s Wisconsin Collection of Photoelectric Detectors in Historical Context
Authors: Lattis Anthony
Published: November 2020

Between 2017 and 2019, the Smithsonian National Air and Space Museum acquired a collection of photoelectric tubes used in the earliest program of astronomical photoelectric photometry at the University of Wisconsin. The Wisconsin Collection of Photoelectric Detectors represents a unique look inside the development of a pioneering research project and a fledgling technology. The process by which techniques and technologies related to photoelectric photometry developed in the early twentieth century involved a variety of academic disciplines and commercial actors, and this process is reflected in the variety and specific features of the tubes in the collection. This paper attempts to situate the Wisconsin Collection within the wider development of photoelectric tubes as a technology, the development of observation techniques at Wisconsin, and their contributions to astronomical knowledge.
Trust in Glass: Negotiating the Purchase of the Object Glass for the Airy Transit Circle
Authors: Belteki Daniel
Published: November 2020

The Airy Transit Circle of the Royal Observatory, Greenwich is one of the most important instruments in the history of astronomy, navigation and time distribution. However, there has been very little research done on the history of the instrument. This article examines how the purchase of the object glass for the Airy Transit Circle involved active negotiations between George Biddell Airy and three different opticians: Georg Merz, Noel Paymal Lerebours, and William Simms. The article also shows the involvement of John Herschel and Richard Sheepshanks in Airy’s decision making process. By highlighting the presence of these individuals, the article shows how Airy’s trust and distrust in different instrument makers influenced his choice of supplier for the object glass of the Airy Transit Circle.
‘Against Any Army’: Italian Radical Party’s Antimilitarism from the 1960s to the Early 1980s
Authors: Bonfreschi Lucia
Published: November 2020

This article focuses on the Italian Radical Party’s (PR) antimilitarism, which combined left liberal with libertarian and anti-authoritarian elements. The aim of the paper is twofold: highlight the existence of a ‘third way’ of mobilisation for peace, distinct from the communist and the Catholic movements that tend to dominate the literature on Italian peace protest; and investigate peace mobilisation not only during the late 1960s or the early 1980s, but also during the 1970s, a decade neglected by historiography. In so doing, the article traces the development of the Radicals’ antimilitarism from its beginning in the 1960s up to the early 1980s, with the aim of understanding the origins of their antimilitarist ideas, their political strategy, their complex mediation between movements and institutions and their efforts to institutionalise antimilitarist issues.
Volunteers for Anarchy: The International Group of the Durruti Column in the Spanish Civil War
Authors: Brodie Morris
Published: November 2020

This article explores the twin phenomena of anti-fascism and transnational war volunteering through a case study of the International Group of the Durruti Column in the Spanish Civil War. This anarchist-led unit comprised approximately 368 volunteers with a variety of political views from at least 25 different countries. The article examines the relationship between these foreign volunteers and their Spanish hosts (both anarchist and non-anarchist), through, firstly, the militarization of the militias in the winter of 1936, and, secondly, the group’s role in the May Days of 1937 and its aftermath. These episodes show the often hostile attitude of Spaniards to foreigners within Spain and challenge the characterization of the conflict as distinctively internationalist. The lives of these volunteers also highlight the continuity of anti-fascism between the interwar and wartime period, with Spain acting as an ‘anti-fascist melting pot’ where volunteers of different backgrounds and political leanings came together in a common cause. This commitment, however, was not unconditional, and was frequently challenged due to circumstances within Spain. Through studying these transnational fighters, we have a more comprehensive understanding of the complex nature of twentieth century anti-fascism.
International Students’ Learning Experience on Global Curriculum
Authors: Munna Afzal Sayed
Published: November 2020

This article intended to analyze a current piece of international education practice in terms of its underlying values, culture, and philosophy, including the concept of international education (e.g., a curriculum model, an organizational or institutional structure, or a management style), and have particularly selected curriculum model to discuss. Furthermore, the article aims to explore and analyze international students’ learning experience in the selected educational curriculums designed for them. Moreover, the article will assess how values, culture, and philosophy influence the learners’ experience in the curriculums.
Early Social Origins of Biological Risks for Men and Women in Later Life
Authors: Morton Patricia M. , Ferraro Kenneth F.
Published: November 2020

We investigate whether childhood exposures influence adult chronic inflammation and mortality risk via adult health characteristics and socioeconomic status (SES) and whether gender moderates these relationships. Analyzing a longitudinal national sample of 9,310 men and women over age 50, we found that childhood SES, parental behaviors, and adolescent behaviors were associated with adult chronic inflammation via health characteristics and SES in adulthood. The process of disadvantage initiated by low childhood SES (i.e., adult health risk factors, socioeconomic disadvantage, and chronic inflammation) subsequently raised mortality risk. In addition, gender moderated the mediating influence of childhood SES via unhealthy behaviors and parental behaviors via adult SES. Demonstrating how social forces shape biological health through multiple mechanisms informs health policies by identifying multiple points of intervention in an effort to reduce the lasting consequences of childhood disadvantage.
Cross-Gender Differences in English/French Bilingual Speakers: A Multiparametric Study
Authors: Pépiot Erwan , Arnold Aron
Published: November 2020

The present study concerns speech productions of female and male English/French bilingual speakers in both reading and semi-spontaneous speech tasks. We investigated various acoustic parameters: average fundamental sound frequency (F0), F0 range, F0 variance ( SD), vowel formants (F1, F2, and F3), voice onset time (VOT) and H1-H2 (intensity difference between the first and the second harmonic frequencies, used to measure phonation type) in both languages. Our results revealed a significant effect of gender and language on all parameters. Overall, average F0 was higher in French while F0 modulation was stronger in English. Regardless of language, female speakers exhibited higher F0 than male speakers. Moreover, the higher average F0 in French was larger in female speakers. On the other hand, the smaller F0 modulation in French was stronger in male speakers. The analysis of vowel formants showed that overall, female speakers exhibited higher values than males. However, we found a significant cross-gender difference on F2 of the back vowel [u:] in English, but not on the vowel [u] in French. VOT of voiceless stops was longer in Female speakers in both languages, with a greater difference in English. VOT contrast between voiceless stops and their voiced counterparts was also significantly longer in female speakers in both languages. The scope of this cross-gender difference was greater in English. H1-H2 was higher in female speakers in both languages, indicating a breathier phonation type. Furthermore, female speakers tended to exhibit smaller H1-H2 in French, while the opposite was true in males. This resulted in a smaller cross-gender difference in French for this parameter. All these data support the idea of language- and gender-specific vocal norms, to which bilingual speakers seem to adapt. This constitutes a further argument to give social factors, such as gender dynamics, more consideration in phonetic studies.
The Securitization and De-Securitization of Kurdish Societal Security in Turkey, Iraq, Iran, And Syria
Authors: Hama Hawre Hasan
Published: November 2020

The four countries hosting Kurdish populations in the Middle East have mainly been politically centralized in character and sought to follow a homogeneous nation-state model through the assimilation of their Kurdish communities. Drawing on the concepts of societal security, securitization, and de-securitization derived from the theories of the Copenhagen School, this article examines Kurdish (in)security in the Middle East and argues that the Kurds have experienced significant societal insecurity due to the adoption of assimilation strategies by their host states. I posit that federalism and power sharing are the two obvious de-securitization strategies that may address the securitization of Kurdish identity in the states with significant Kurdish populations. I further argue that, while the federal model has appeared to manage securitized Kurdish identity in Iraq since 2003, this solution may not be applicable to Turkey, Iran, and Syria. Alternatively, consociational power sharing as a form of institutional de-securitization carries the potential to address Kurdish identity in these countries.
Event-triggered robust model predictive control for Lipschitz nonlinear networked control systems subject to communication delays
Authors: Ghorbani Saeid , Safavi Ali Akbar , Naghavi S. Vahid
Published: November 2020

In this paper, the problem of event-triggered robust model predictive control (MPC) was examined for a class of Lipchitz nonlinear networked control systems (NCS) with network-induced delays and subject to external disturbances. An event-triggering scheme for a continuous-time NCS was proposed, which reduced the communication traffic and computational burden of the MPC algorithm simultaneously. In comparison with the existing event-triggered nonlinear MPC (NMPC) approaches, the controller in this paper was designed as a state feedback control law, which minimized a “worst-case” performance index over an infinite horizon subject to constraints on the control input. The controller and event generator parameters were developed as a convex optimization problem, encompassing some linear matrix inequalities (LMIs). Simulation results showed that the proposed event-triggering NMPC scheme preserved closed-loop performance while reducing the communication rate and the computational time.
Research practices of LIS professionals in Pakistan: A study of attitudes, involvement and competencies
Authors: Sheikh Arslan , Malik Amara , Mahmood Khalid
Published: November 2020

This study analyses the attitudes, involvement and competencies of Pakistani Library Information Science (LIS) professionals towards research. An online survey was carried out by using a questionnaire to collect data from LIS professionals working in various types of libraries in Pakistan. The findings reveal that the overall attitude of the Pakistani LIS professionals towards research is positive. A vast majority of them read research literature, albeit occasionally, while a small majority read the full-text articles. Two local journals, Pakistan Library & Information Science Journal (PLISJ) and Pakistan Journal of Information Management & Libraries (PJIML), are the top read titles. Though research contributions counted towards promotion of LIS professionals, a very small majority of them were currently engaged in research project/s. They do not feel very confident about their research expertise, yet aspire to increase their knowledge of research. Some of the factors that deter LIS professionals from engaging in research are: a lack of time, little support from their organisation, lack of research ideas and lack of research skills. Institutional support in terms of time, money and educational training would enhance opportunities for LIS professionals to produce more research and publication.
Race and SES Differences in Psychosocial Resources: Implications for Social Stress Theory
Authors: Thomas Tobin Courtney S. , Erving Christy L. , Barve Apurva
Published: November 2020

Social stress theory predicts that psychosocial resources shape health inequalities but is less clear about the ways in which the availability of resources differs across racial and socioeconomic groups. Using data from the Nashville Stress and Health Study (N = 1,214), the present study assessed racial and socioeconomic status (SES) differences in mastery, self-esteem, and social support; evaluated the extent to which SES accounts for racial differences in resources; and considered the interactive roles of race and SES in shaping resources among Black and White adults. Results show Blacks have greater access to resources, but SES yields greater psychosocial benefits among Whites. Findings demonstrate that SES and race may jointly and independently shape access to resources. This study contributes to the broader literature on status distinctions in psychosocial resources, providing new insights into the ways in which race and SES shape access to these health-protective resources while also raising several questions for future research.
Foucault on Raymond Roussel: The Extralinguistic Outside of Literature
Authors: Blanco Azucena G.
Published: November 2020

Madness, Language, Literature (2019) brings together a series of unpublished works on literature that belong to Michel Foucault’s first stage of production. This article focuses on those works that express a concept of madness as social partition or outside, and also on those that elucidate the concept of the ‘extralinguistic’ of literature. The combined reading of these texts sheds light on a concept of the extralinguistic outside of literature that enables Foucault to overcome a concept of ontological outside and, therefore, using literature, think on this discourse’s historical possibilities of resistance. As a result of this new reading, I analyse some fundamental aspects of this early Foucault. First, his development of a politics of literary form in the 1960s. Second, I propose that Foucault’s studies on literature in the 1960s were a kind of laboratory in which he was already raising some questions concerning his political history of truth. And, lastly, I examine the capacity of literature to make visible a part of reality that remains hidden (the excluded), the processes by which literature creates (language’s mechanism of self-representation), the possible forms of subjectivation that the fiction of every episteme allows (what Foucault calls verisimilitude), and the formulation of novel forms of being (that he later developed as aesthetics of existence).
Mobility levels of acute medical patients: Is behavioural mapping comparable to accelerometry?
Authors: Wu Yizhou , Smits Esther J , Window Peter , Beningfield Alice , Johnston Venerina , McRae Prue
Published: November 2020

Objective:

To (1) determine agreement between behavioural mapping and accelerometry for measuring mobility levels in an acute medical inpatient setting and to (2) explore and compare the required resources and costs for both methods.

Design:

Observational cross-sectional study

Setting:

Tertiary referral teaching hospital in Brisbane, Australia.

Subjects:

Adult patients admitted to two acute medical wards.

Main measures:

Mobility levels were recorded by behavioural mapping, and thigh and chest-worn accelerometers (ActivPAL). The level of agreement between the two methods was evaluated using the Intraclass Correlation Coefficients for each mobility level (i.e. lying, sitting, upright, standing and walking).

Results:

Nineteen patients (10 male (53%); mean(SD) age of 72(14) years) were included in the agreement analysis. The Intraclass Correlation Coefficients were high for ‘lying’ (ICC = 0.87), ‘sitting’ (ICC = 0.84) and ‘upright’ (ICC = 0.93), indicating good to excellent agreement between the two methods. For these mobility levels, mean differences between the two methods were small (<2%), with large standard deviations (up to 18%). Agreement was poor for ‘standing’ (ICC = 0.00) and ‘walking’ (ICC = 0.35). Both methods were labour-intensive, with labour costs of A$1,285/€798 (34 hours) for behavioural mapping and A$1,055/€655 (28 hours) for accelerometry. No further costs were involved in behavioural mapping, but clinical backfill was required. Accelerometry involved a financial investment for accelerometers (A$11,100/€6,894 for 22 ActivPAL devices).

Conclusion:

Agreement between behavioural mapping and accelerometry was good for measuring ‘lying’, ‘sitting’ and ‘upright’, but poor for ‘standing’ and ‘walking’ in an acute inpatient setting. Both behavioural mapping and accelerometry were labour-intensive, with high costs for the accelerometry equipment.
Cranioplasty as the treatment for contralateral subdural effusion secondary to decompressive craniectomy: a case report and review of the relevant literature
Authors: Wang Hao , Chen Fumei , Wen Liang , Zhu Yuanrun , Chen Zuobing , Yang Xiaofeng
Published: November 2020

Subdural effusion (SDE) is a common complication secondary to decompressive craniectomy (DC). This current case report describes a patient with contralateral SDE with a typical clinical course. Initially, he made a good recovery following a head trauma that caused a loss of consciousness and was treated with decompressive craniectomy. However, he only achieved temporary relief after each percutaneous fluid aspiration from an Ommaya reservoir implanted into the cavity of the SDE. He was eventually transferred to the authors’ hospital where he underwent cranioplasty, which finally lead to the reduction and disappearance of his contralateral SDE. Unexpectedly, his clinical condition deteriorated again 2 weeks after the cranioplasty with symptoms of an uncontrolled bladder. A subsequent CT scan found the apparent expansion of the whole cerebral ventricular system, indicating symptomatic communicating hydrocephalus. He then underwent a ventriculoperitoneal shunt procedure, which resulted in a favourable outcome and he was discharged 2 weeks later. A review of the current literature identified only 14 cases of contralateral SDE that were cured by cranioplasty alone. The mechanism of contralateral SDE has been widely discussed. Although the exact mechanism of contralateral SDE and why cranioplasty is effective remain unclear, cranioplasty could be an alternative treatment option for contralateral SDE.
Neuroleptic malignant syndrome with abnormally elevated cardiac troponin I: a case report
Authors: Wang Qiang , Shi Jiabo , Zhao Peng , Cao Qiuyun , Yao Zhijian
Published: November 2020

Neuroleptic malignant syndrome (NMS) is a life-threatening neurological emergency that is primarily characterized by altered consciousness, hyperpyrexia, muscular rigidity, and autonomic instability. Here, we describe a unique case of NMS. A 54-year-old woman with major depressive disorder (MDD) was admitted to our hospital to relieve painful emotions; her laboratory tests and physical examinations were unremarkable. Her medication regime was as follows: day 1, quetiapine (200 mg), clonazepam (2 mg), and zopiclone (7.5 mg); day 2, olanzapine (5 mg) and sertraline (100 mg); day 3, olanzapine (15 mg), sertraline (100 mg), zopiclone (7.5 mg), and clonazepam (2 mg); day 4, olanzapine (15 mg) and haloperidol (5 mg); and day 5, sertraline (50 mg) and olanzapine (5 mg). The patient then developed NMS, and a series of tests showed further abnormalities. Unusually, her cardiac troponin I (TNI) was abnormally elevated as her NMS symptoms worsened, but gradually decreased after she was transferred to the cardiology department for treatment. The increased TNI was suspected to be related to the NMS. Here, we provide several potential explanations for the relationship between TNI and NMS. Based on the present case, it may be important to measure and monitor TNI concentrations in NMS patients.
Temporospatial Development of Neuropathologic Findings in a Canine Model of Mucopolysaccharidosis IIIB
Authors: Harm Tyler A. , Hostetter Shannon J. , Nenninger Ariel S. , Valentine Bethann N. , Ellinwood N. Matthew , Smith Jodi D.
Published: November 2020

Mucopolysaccharidosis (MPS) IIIB is a neuropathic lysosomal storage disease characterized by the deficient activity of a lysosomal enzyme obligate for the degradation of the glycosaminoglycan (GAG) heparan sulfate (HS). The pathogenesis of neurodegeneration in MPS IIIB is incompletely understood. Large animal models are attractive for pathogenesis and therapeutic studies due to their larger size, outbred genetics, longer lifespan, and naturally occurring MPS IIIB disease. However, the temporospatial development of neuropathologic changes has not been reported for canine MPS IIIB. Here we describe lesions in 8 brain regions, cervical spinal cord, and dorsal root ganglion (DRG) in a canine model of MPS IIIB that includes dogs aged from 2 to 26 months of age. Pathological changes in the brain included early microscopic vacuolation of glial cells initially observed at 2 months, and vacuolation of neurons initially observed at 10 months. Inclusions within affected cells variably stained positively with PAS and LFB stains. Quantitative immunohistochemistry demonstrated increased glial expression of GFAP and Iba1 in dogs with MPS IIIB compared to age-matched controls at all time points, suggesting neuroinflammation occurs early in disease. Loss of Purkinje cells was initially observed at 10 months and was pronounced in 18- and 26-month-old dogs with MPS IIIB. Our results support the dog as a replicative model of MPS IIIB neurologic lesions and detail the pathologic and neuroinflammatory changes in the spinal cord and DRG of MPS IIIB-affected dogs.
Chlamydia pecorum–Associated Sporadic Ovine Abortion
Authors: Westermann Thomas , Jenkins Cheryl , Onizawa Emily , Gestier Sarah , McNally Justine , Kirkland Peter , Zhang Jing , Bogema Daniel , Manning Leah K. , Walker Keith , Pinczowski Pedro
Published: November 2020

Despite previous detection of Chlamydia pecorum in sporadic ovine abortions, published descriptions of naturally occurring infections with fetoplacental lesions are lacking. This report provides the first descriptions of severe necrosuppurative chorionitis with vasculitis, and fetal pyelonephritis and enteritis in late-term abortions of maiden ewes. Chlamydial infection was detected using a Chlamydia genus-specific qPCR (quantitative polymerase chain reaction) on tissue extracts from 3 fetuses. C. pecorum was identified using a targeted qPCR assay, which also determined infectious load within fetal tissues. The presence of viable C. pecorum in fetal samples was confirmed by cell culture. Multilocus sequence typing (MLST) data indicated that the C. pecorum strains from each fetus were identical and of sequence type (ST) 23. Chlamydia sp. immunohistochemistry showed strong positive immunolabeling of fetoplacental lesions. Other infectious abortigenic agents were excluded with specific testing. This report confirms C. pecorum as a likely cause of ovine abortion and provides the first descriptions of associated fetoplacental lesions in naturally infected sheep.
Comparison of AA Amyloid Fibril Morphology and Serum Amyloid A Gene Sequence in 5 Animal Species
Authors: Lin Xuguang , Kuragano Masahiro , Watanabe Kenichi , Tokuraku Kiyotaka
Published: November 2020

Amyloid fibrils are characterized by a linear morphology and a cross-β structure. Polymorphic and multiple fibril morphologies can be found when amyloid fibrils are extracted from amyloid-laden tissue. In this study, we report on the purification and transmission electron microscopic analysis of amyloid fibrils from 5 different animal species (mouse, cow, goat, dog, and camel) with AA amyloidosis. The results show that amyloid fibrils had a linear morphology with a cross-structure and irregular length in vivo. Although the fibrils from these different species showed highly similar conformations, there were significant differences in fibril width and crossover distance. We analyzed the sequences of homologous amyloid proteins and serum amyloid A, an evolutionarily conserved protein and a major amyloid precursor. We found 78.23% homology between the most distant amyloid proteins. The findings suggested similar fibril width and crossover distance in different animal species that displayed high homology of amyloid protein sequences. Dog and camel, as well as goat and cow, showed high genetic homology and similar fibril morphology. These data indicate that the fibrils from different animal species have similar genetic homology and morphology, which may provide a better understanding of the pathogenesis of amyloidosis.
Age-Related Changes in the Canine Aorta
Authors: Yang Ching , Kohnken Rebecca
Published: November 2020

Degenerative changes in the aorta are commonly observed in both dogs and humans, and those changes that occur with age morphologically overlap with those observed in genetic or degenerative diseases. Therefore, recognition of age-related aortic changes is important for diagnosticians, as such histologic findings should be distinguished from lesions of specific diseases. The aortas from 37 dogs without clinical cardiovascular disease ranging in age from 2 months to 15 years were divided into 3 cohorts to assess age-relatedness, and evaluated histologically using standardized nomenclature and diagnostic criteria adapted and modified from the human literature. We found that the histopathologic severity scores for intimal thickening, translamellar medial fibrosis, loss of smooth muscle cell nuclei, and medial microcalcification were higher in older dogs, whereas the scores for both intralamellar and translamellar mucoid extracellular matrix accumulation (“cystic medial necrosis”) were not different among age groups. Dogs with translamellar medial fibrosis and aortic medial microcalcification were significantly older compared with dogs without these findings, while the presence of aortic medial chondro-osseous metaplasia was not related to age. Taken together, we demonstrate a range of age-related aortic histologic changes in dogs without clinical cardiovascular disease and suggest that integration of signalment and clinical data can aid in the differentiation of such findings from non-age-related disease processes.
Shopping for an Orthodontist
Authors: Katti Chandrika G. , Mohan Archana
Published: November 2020

Choosing an orthodontist is one of the most important decisions patients need to make for their beautiful smiles. What are the factors that lead a patient to choose an orthodontist for their treatment? To find an answer, a survey was conducted to explore information from patients about the factors influencing them for choosing an orthodontic practice.

The questionnaire focused on the role of social media, qualification, patient feedback, general dentist referral, treatment cost, reputation of the dentist, latest technologies used, age and gender of the practitioner, and location of clinic in the selection of an orthodontist by the patient. The research included 400 new orthodontic patients visiting dental college and orthodontic office.

The study concluded that advertising tools such as social media, qualification and reputation of the practitioner, feedback from previous patient, age and gender of the practitioner, and dentist referral were important criteria in selecting an orthodontist.
The Northern Necropolis of Gebelein in Light of Old and Current Fieldwork
Authors: Ejsmond Wojciech , Skalec Aneta , Chyla Julia M.
Published: November 2020

The Northern Necropolis of Gebelein was a place of important discoveries, e.g. an archive of Old Kingdom papyri, the Tomb of Unknowns, and the Tomb of the General Iti II. Several excavations have taken place there, but none have been sufficiently published. The archaeological contexts of these discoveries are poorly known, which limits their research value. Archival data from two unpublished excavations can help to understand the archaeological topography of the eastern part of this cemetery. The current survey of the area enables the authors to understand the progress of previous excavations, to locate in the field some of the archaeological features discovered during the twentieth century excavations, and contributes to contextualisation of some of the artefacts which were discovered at the cemetery. The necropolis in question presents the development of an important, provincial burial ground which can contribute to the understanding of the history of the region and the funerary traditions in provincial areas. Worth to note are the peculiarities, such as an Old Kingdom mastaba with subsidiary burials within its walls, mummified dogs in a Twelfth Dynasty tomb, and Nubian influence on local funerary customs.
The Role of Graffiti Game Boards in the Understanding of an Archaeological Site: The Gebel el-Silsila Quarries
Authors: de Voogt Alex , Nilsson Maria , Ward John
Published: November 2020

Graffiti game boards attest to the presence of historical populations at an archaeological site and, in some cases, assist in dating an archaeological context. While games suggest the presence of a social activity, their contextual significance compared to the graffiti of texts and images, pottery finds, and other diagnostic tools of archaeology is open to further enquiry. The presence of multiple board game traditions at Gebel el-Silsila in Egypt creates an ideal environment to study the differences between graffiti texts and images, excavated materials and game boards when they are found in the same location. It is shown that game boards may confirm human presence in different historical time periods for which only limited additional evidence exists, or they may signal the presence of a different historical population. Their symbolic significance remains unclear, but game boards otherwise provide an independent source of information and an asset to a general archaeological inquiry.
Postoperative use of slow-release opioids: The impact of the Australian and New Zealand College of Anaesthetists/Faculty of Pain Medicine position statement on clinical practice
Authors: Tan Adeline CH , Bugeja Bernadette A , Begley David A , Stevens Jennifer A , Khor Kok-Eng , Penm Jonathan
Published: November 2020

Dose titration with immediate-release opioids is currently recommended for acute pain. The Australian and New Zealand College of Anaesthetists and the Faculty of Pain Medicine released a statement in March 2018 supporting their use in the treatment of opioid-naïve patients; however, the impact of this statement on clinical practice is currently unknown. This retrospective cohort study was conducted to compare opioid prescribing patterns before and after the release of the recommendations. Data were collected on 184 patients (2017, n = 78; 2018, n = 106) admitted to the Prince of Wales Hospital in November 2017 and 2018, which consisted of demographic data, opioid prescriptions and discharge opioid information. The main outcome is the number of prescriptions of slow-release opioids in 2017 versus 2018 after the recommendations were published. Confounding factors were accounted for using logistic and multiple regression as appropriate. There was a 29% decrease in slow-release opioid prescriptions during hospitalisation ( n = 31, 40% versus n = 12, 11%; P < 0.001) and 17% decrease at discharge ( n = 20, 26% versus n = 9, 9%; P = 0.02) post-publication. After adjusting for confounders, the odds of slow-release opioids being prescribed postoperatively and at discharge reduced by 86% and 88%, respectively (postoperative period: odds ratio 0.14, P < 0.05; discharge: odds ratio 0.12, P < 0.05). In addition, orthopaedic patients were more likely to receive slow-release opioids, consistent with existing literature. As the use of slow-release opioids has been associated with increased harm and protracted opioid use compared to immediate-release opioids, it is hoped that wider dissemination of these recommendations and a change in prescribing practice can be a step towards overcoming the opioid crisis.
Professional Development of Code and Robotics Teachers Through Small Private Online Course (SPOC): Teacher Centrality and Pedagogical Strategies for Developing Computational Thinking of Students
Authors: Hadad Shlomit , Shamir-Inbal Tamar , Blau Ina , Leykin Eynat
Published: November 2020

This study explored (1) pedagogical strategies in Educational Coding and Robotics (ECR) learning which can develop computational thinking of students and (2) the degree of teacher centrality in the ECR classroom. In addition, we investigated (3) the added value of the Small Private Online Course (SPOC) to teacher professional development (TPD). We analyzed reflections of 80 in-service teachers on TPD through the SPOC (1,091 statements) and conducted semi-structured interviews with 13 of them one year after completing the course and teaching ECR in the classroom (328 statements). The most prominent strategies immediately after the TPD were constructing learning experiences, tinkering & debugging, and interdisciplinary learning, while one year later, experiential learning and collaborative learning were more common. Regarding the degree of teacher centrality, a year after teaching ECR curriculum the teachers had a significantly higher percentage of statements reflecting their role as a guide-on-the-side and as a partner of students in the learning process. Regarding the contribution of the SPOC for TPD, teacher statements revealed significantly more benefits than challenges in both points of time. Interestingly, the same categories emerged bottom-up as benefits and challenges: a variety of control dimensions, independent learning, learning and knowledge management and collaboration. Implications for educational theory and ECR practice are discussed.
Cerebrospinal Fluid Analysis for Viruses by Metagenomic Next-Generation Sequencing in Pediatric Encephalitis: Not Yet Ready for Prime Time?
Authors: Erdem Guliz , Kaptsan Irina , Sharma Himanshu , Kumar Arvind , Aylward Shawn C. , Kapoor Amit , Shimamura Masako
Published: November 2020

Background:

Metagenomic next-generation sequencing offers an unbiased approach to identifying viral pathogens in cerebrospinal fluid of patients with meningoencephalitis of unknown etiology.

Methods:

In an 11-month case series, we investigated the use of cerebrospinal fluid metagenomic next-generation sequencing to diagnose viral infections among pediatric hospitalized patients presenting with encephalitis or meningoencephalitis of unknown etiology. Cerebrospinal fluid from patients with known enterovirus meningitis were included as positive controls. Cerebrospinal fluid from patients with primary intracranial hypertension were included to serve as controls without known infections.

Results:

Cerebrospinal fluid metagenomic next-generation sequencing was performed for 37 patients. Among 27 patients with encephalitis or meningoencephalitis, 4 were later diagnosed with viral encephalitis, 6 had non–central nervous system infections with central nervous system manifestations, 6 had no positive diagnostic tests, and 11 were found to have a noninfectious diagnosis. Metagenomic next-generation sequencing identified West Nile virus (WNV) in the cerebrospinal fluid of 1 immunocompromised patient. Among the 4 patients with known enterovirus meningitis, metagenomic next-generation sequencing correctly identified enteroviruses and characterized the viral genotype. No viral sequences were detected in the cerebrospinal fluid of patients with primary intracranial hypertension. Metagenomic next-generation sequencing also identified sequences of nonpathogenic torque Teno virus in cerebrospinal fluid specimens from 13 patients.

Conclusions:

Our results showed viral detection by cerebrospinal fluid metagenomic next-generation sequencing only in 1 immunocompromised patient and did not offer a diagnostic advantage over conventional testing. Viral phylogenetic characterization by metagenomic next-generation sequencing could be used in epidemiologic investigations of some viral pathogens, such as enteroviruses. The finding of torque Teno viruses in cerebrospinal fluid by metagenomic next-generation sequencing is of unknown significance but may merit further exploration for a possible association with noninfectious central nervous system disorders.
Positioning accuracy degradation and lifetime prediction of the ball screw considering time-varying working conditions and feed modes
Authors: Cheng Qiang , Qi Baobao , Liu Zhifeng , Yang Congbin , Zheng Jigui
Published: November 2020

Ball screw mechanisms (BSMs) are used as accuracy transmission components in a wide range of industries and are characterized by their high accuracy. More specifically, the positioning accuracy of BSM has a significant effect on the accuracy of machine tool. Based on the macro-micro multiscale method, an exponential prediction model for the BSM positioning accuracy was developed considering time-varying working conditions (load and rotational speed) and feed modes. Since the accuracy degradation is mainly caused by wear, a microscopic approach was proposed to describe the positioning accuracy retention and the microscopic wear process was investigated. The sliding contact of the asperities between the ball and raceway was analyzed, and the microscopic wear behavior of the asperities was determined. Considering the time-varying working conditions, the BSM positioning accuracy characteristics were obtained under the normal feed mode by conducting suitable tests. The exponential wear model used the wear index to describe the wear status based on the positioning accuracy measurement. The accuracy loss value and the prediction index of positioning accuracy were determined based on an exponential model, and the effective lifetime of the BSM was predicted. Finally, the exponential prediction model was used in negative/positive skew feed distribution, and the effective lifetime determined.