bluuebunny/crossref_metadata_2025 huggingface dataset:
Theoretical Kinetics Study Of The HO2 + C2H5OH Hydrogen Abstraction Reaction
Authors: Nghia Nguyen Trong
Published: March 2020

C2H5OH has been using as an alternative fuel for decades; HO2 also plays a pivotal role in the combustion. The kinetics and mechanism for the reaction between C2H5OH and HO2 radical has been investigated using the molecular parameters for the reactants, transition states and products predicted at the CCSD(T)//B3LYP/6-311++G(3df,2p) level of theory. There are ten pair products have been found including C2H5O + H2O2 (PR1), CH3CHOH + H2O2 (PR2), CH2CH2OH + H2O2 (PR3), CH3CH2OOOH + H (PR4), C2H5 + HOOOH (PR5), CH3CH2OOH + OH (PR6), CH3CH(OH)OOH + H (PR7), HOCH2CH2OH + H (PR8), HOOCH3 + CH2OH (PR9), and CH3 + HOOCH2OH (PR10) in which the second and third ones are the major channels. The rate constants and branching ratios for all H-abstraction reactions have been calculated using the conventional transition state theory with asymmetric Eckart tunneling corrections for the temperature ranging from 298 to 2000 K.
Peningkatan Mutu Sarana Pendidikan Melalui Pengembangan Self Access Library For English Students (SALE)
Authors: Hidayati Fithriyah Nurul , Fatmawati Nor Laili
Published: March 2020

The research and development of Self Access Library for English Studets (SALE) is aimed at increasing the quality of educational tools as mandated by Permenristekdikti RI No. 44 2015 and its change Permenristekdikti RI No. 50  2018 about National Standard of Higher Education (SN Dikti). It is conducted based on the need of students of PBI IAIN Surakarta for comprehensive, accurate, easily accessible and inexpensive learning sources. Thus, SALE is initiated as an online library providing 126 English e-books classified based on the syllabus of PBI, covering the topics on English education, linguistics ang literature so the students can find appropriate learning sources easily. SALE also gives the students connections to some experts so they can meet virtual consultants or discussion partners to confirm their reading comprehension on the issues concerned. The research and development include some steps; observing potential problems, collecting data, designing SALE, validating the product by experts, first revision, small group trial, second revision, user trial, packaging, and final product. The score of validation by the experts and small group trial shows that SALE is categorized very good and eligible. It means SALE is ready to be an alternative learning source provider with qualified long distance service. The use of SALE by the students causes the improvement on students’ tasks quality as the result of an easy access to some important references appropriate with their majors. Therefore, SALE has become an evidence of the efforts to improve the quality of educational toools at IAIN Surakarta, particularly at PBI department
Comparison of Rock Type Determination Based on Permeability Estimation and FZI Value in Upper Cibulakan Shaly Sand Formation, ASR Field
Authors: Rahesthi Anditya Sapta , Sitaresmi Ratnayu , Rahmawan Sigit
Published: March 2020

Rock permeability is an important rock characteristic because it can help determine the rate of fluid production. Permeability can only be determined by direct measurement of core samples in the laboratory. Even though coring gives good results, the disadvantage is that it takes a lot of time and costs so it is not possible to do coring at all intervals. So that the well log is required to predict the level of permeability indirectly. However, the calculation of permeability prediction using well log data has a high uncertainty value, so rock typing is required so that the calculation of permeability prediction becomes more detailed. This research was conducted in an effort to determine the Hydraulic Flow Unit (HFU) of the reservoir in the well that has core data using the Flow Zone Indicator (FZI) parameter and FZI value propagation on wells that do not have core data so that the type of rock and permeability value are obtained from every well interval. From the results of the study, the reservoirs on the ASR field can be grouped into six rock types. The six rock types each have permeability as a function of validated porosity by applying it at all intervals. After FZI is calculated from log data and validated with core data, it can be seen that the results of the method produce a fairly good correlation (R2 = 0.92). Furthermore, from the permeability equation values for each different rock type, the predicted permeability results are also quite good (R2 = 0.81).
2019 Novel Coronavirus: A mysterious threat from Wuhan, China–A current review
Authors: Ramalingam Kothai  , Balasubramanian Arul
Published: March 2020

Coronaviruses (CoV) are a huge family of viruses and they cause various diseases from the common cold to very serious illnesses. They also just like the Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). But novel coronavirus (nCoV) is a different strain and newly discovered in humans. Several known coronaviruses circulate in animals not yet infected by humans. It is also a zoonotic virus, which means that they are spread between animals and then to humans. Comprehensive studies showed that SARS-CoV was transmitted to humans by civet cats and MERS-CoV by dromedary camels. Respiratory symptoms, fever, cough, shortness of breath and difficulty in breathing are common signs of infection. It was started from Huanan wholesale seafood market with the admission of 2-3 patients and now crossed 37251 cases with 812 deaths as on 9th February. In some of the days, the number of new admissions was more than 3000 cases continuously. This review summarises the types, morphology, origin, transmission, symptoms, diagnostic methods, Chinese, global and Indian scenario of this novel deadly virus. The world health organization advises for the public about the avoiding of the spread of the virus, general recommendations for individuals and for the risk groups also reviewed.
MÔ HÌNH PHÂN BIỆT QoS DỰA TRÊN THỜI GIAN BÙ ĐẮP VÀ KÍCH THƯỚC CHÙM TRONG MẠNG OBS.
Authors: Đức Phạm Trung , Chương Đặng Thanh
Published: March 2020

Với sự gia tăng lưu lượng truy cập Internet trong thời gian gần đây, việc sử dụng mạng quang là xu hướng tất yếu nhằm đáp ứng nhu cầu băng thông lớn hơn, tốc độ truyền dữ liệu nhanh hơn và đặc biệt là hỗ trợ chất lượng dịch vụ (QoS) tốt hơn. Đối với mạng chuyển mạch chùm quang (mạng OBS), phân biệt dịch vụ được tiếp cận theo hai hướng: dựa trên thời gian bù đắp và dựa trên kích thước chùm. Bài báo này sẽ đề xuất một kết hợp phân biệt dịch vụ dựa trên cả thời gian bù đắp và kích thước chùm, có tên gọi là mô hình OT-BLD. Kết quả mô phỏng và phân tích cho thấy rằng mô hình OT-BLD đạt được hiệu quả đáng kể không chỉ làm giảm tỉ lệ mất mát đối với các chùm ưu tiên cao mà còn giảm được độ trể truyền thông đầu cuối của chúng so với các chùm ưu tiên thấp.
A roma kisebbség helyzete a nemzetközi és az európai jogban
Authors: Szemesi Sándor
Published: March 2020

Könyvismertető Szalai Anikó Protection of the Roma Minority under International and European Law. (Eleven International Publishing, the Hague, 2015.) című munkájáról.
Támogatni vagy nem támogatni? Filmtámogatási rendszerek kritikai megközelítése: az amerikai és az európai modell
Authors: Szalay Klára
Published: March 2020

Jelen tanulmány célja, hogy a filmtámogatási rendszerek eredetét ismertesse, összehasonlítva az amerikai és európai fejlődés eltérő mozgatórugóit, amelyek az egyre erősödő filmtámogatási verseny globalizációjához vezettek. Az Európai Unió szabályai a filmgyártás területén az Európai Unió Működéséről Szóló Szerződés (EUMSZ) állami támogatási szabályait szabályozó cikkeinek fényében, valamint az Európai Bizottság Filmművészeti Közleménye támogatási szabályainak figyelembevételével kerültek rögzítésre.
The effect of processed Tempeh Gembus to triglycerides levels and insulin resistance status in women with obesity
Authors: Nadia F.S. , Wati D.A. , Isnawati M. , Sulchan M. , Afifah D.N.
Published: March 2020

Obesity is an increasing weight that exceeds the limits of physical and skeletal needs due
to the excessive backfilling of body fat. Obesity is a predisposing factor for increasing
triglyceride levels (TG) and insulin resistance status. Consumption of fiber, such as
Tempeh Gembus can be an alternative treatment to lower TG levels and insulin resistance
status. This research was aimed to prove the influence of processed Tempeh Gembus to
TG levels and insulin resistance status. This research employed a pre-post randomized
control group. The participants of this research are 40 women with pre-menopausal
obesity which are divided into two groups: the control group which is given the daily
standard diet treatment Isocaloric 30 kcal/kg of BW/day and the treatment group which is
given the daily standard diet Isocaloric 30 kcal/kg of BW/day with the addition of
processed Tempeh Gembus processed as much as 150 g/day for 28 days. The result show,
giving Tempeh Gembus to the treatment group can lower the TG level (p = 0.010) and
insulin resistance status (p = 0.000) significantly. The decreased levels of TG in the
treatment group (-9.3±9.6 mg/dL) were higher compared to the decline in the control
group (-2.90±4.43 mg/dL). Decreased insulin resistance status in the control group (-
0.60±0.51) is lower than the treatment group (-6.90±4.82). Based on the results above,
consumption of 150 g/day of processed Tempeh Gembus for 28 days can lower TG levels
Clinical and angiographic results of long-term follow-up of patients after endovascular treatment for spinal arteriovenous malformations
Authors: Shchehlov D.V. , Svyrydiuk O.E. , Naida A.V. , Samonenko Yu.M. , Slobodian O.V.
Published: March 2020

Objective – to evaluate long-term results of treatment of patients with arteriovenous malformations AVM of the spinal cord. Materials and methods. A retrospective analysis of clinical and angiographic data of the results of treatment of patients with spinal AVM for the period from 2005 to 2019 was conducted. In SO «Scientific-Practical Center of Endovascular Neuroradiology NAMS of Ukraine» 47 patients were operated on endovascular method. The age of patients ranged from 11 to 62 years (middle age is 45.3 years). There were 29 men (61.7 %), 18 women (38.3 %). Liquid cyanoacrylate embolizant was used for endovascular intervention. The operations were performed with transfemoral access. Accoding the classification proposed by Anson and Spetzler in 1992 patients with type I were 31 (65.9 %), with ІІ type – 8 (17.0 %), with ІIІ type – 5 (10.6 %), with IV type – 3 (6.4 %). Magnetic resonance tomography and spinal angiography were used for diagnostics AVM.Results. Total exclusion of AVM from the bloodstream was achieved in 22 (46.8 %) cases. Out of the 31 (65.9 %) patients with type I AVM, 17 (54.8 %) had an early transient deepening of the neurological deficit. In this group, complete dissection of arteriovenous fistula was achieved in 16 (51.6 %) patients. In 8 (17.0 %) patients with type II AVM, complete exclusion of AVM was achieved in 5 (62.5 %) cases. In this case, 6 (75.0 %) patients were observed early postoperative deepening of neurological symptoms. In 5 (10.6 %) patients with type III AVM, total exclusion was achieved in 1 (20.0 %) case. Transient deepening of neurological deficit was noted in 3 (60.0 %) patients. In 3 (75.0 %) patients with type IV AVM, total embolization was achieved in 1 (33.0 %) observation. Neurological impairment occurred in 1 (33.0 %) patient. In all groups there were no fatalities.Conclusions. Angiography is the gold standard of diagnosis and dynamic monitoring of patients with spinal cord AVM. The use of endovascular treatment of AVM can stop the further progression of neurological deficits, which, however, is not always associated with the total exclusion of AVM. The best neurological improvement and total exclusion were achieved in patients with type I AVM. Radicality, efficacy and deepening of neurological deficiency depend on angioarchitectonics of AVM. The main condition for carrying out embolization is to achieve a safe level of catheterization of the afferent.
Left ventricular hypertrophy: differential diagnosis
Authors: Nosenko N.M. , Shchehlov D.V. , Mamonova M.Yu. , Kudelskyi Ya.E.
Published: March 2020

There are some imaging methods for the diagnosis of left ventricular hypertrophy. Such as echocardiography, computed tomography, magnetic resonance imaging. These methods help to identify changes at different stages, evaluate the prognosis, stratify the risk and differential diagnosis.The left ventricle hypertrophy is a condition that may be due to physiological adaptation due to overload. For example, in patients with arterial hypertension, in athletes, and so on. Left ventricle hypertrophy may also be associated with a change in the actual structure: for example, with hypertrophic cardiomyopathy.Signs of left ventricle hypertrophy by echocardiography are a very significant predictor of mortality in patients with arterial hypertension in the general population. The presence of left ventricle hypertrophy by echocardiography is a high cardiovascular risk for the patient.It is important to diagnose diseases with a high risk of sudden cardiac death on time. One of these diseases is hypertrophic cardiomyopathy. A clinical diagnosis of hypertrophic cardiomyopathy is impossible without visualization. Therefore, the European Association of Cardiovascular Imaging recommends a multimodal approach in examining patients with hypertrophic cardiomyopathy.Сomputed tomography, echocardiography, and magnetic resonance imaging are used to diagnose which patient’s hypertrophy is pathological or physiological. The choice of which method to use depends on the diagnostic task, and also on the specific advantages and disadvantages of the method. Different visualization methods should be considered complementary, not competing. It is also important to choose a particular imaging technique given its diagnostic value, availability, benefits, risks and costs.
Um estudo de conceitos do sistema de numeração decimal por alunos do 4º ano do ensino fundamental mediante o uso de jogos
Authors: Do Nascimento Silva Thaís Coelho
Published: March 2020

No presente artigo apresentamos uma discussão acerca dos conhecimentos de alunos dos anos iniciais referentes ao Sistema de Numeração Decimal (SND) por meio de atividades realizadas com jogos. Para tanto, nos concentramos em analisar os conceitos e propriedades que os alunos mobilizaram tendo como aporte teórico a teoria de Registros de Representação Semiótica. Os principais registros analisados são os numéricos, o registro da língua natural, bem como representações próprias dos alunos investigados. Para desenvolvimento do trabalho nos apoiamos na construção de uma sequência didática inspirada nos princípios da Engenharia Didática. Como resultados, constatamos que os alunos muitas vezes trabalham com a representação do número em seu registro numérico sem compreensão das propriedades do sistema de numeração decimal.
Aprendizagem baseada em problemas (abp) aplicada ao ensino de estatística inferencial não paramétrica no Ensino Superior
Authors: Frei Fernando
Published: March 2020

Este trabalho apresenta a aplicação do modelo de Aprendizagem Baseada em Problemas (ABP) no ensino de Estatística Inferencial Não Paramétrica. A pesquisa foi desenvolvida com 39 alunos do curso de graduação em Engenharia Biotecnológica da Universidade Estadual Paulista – UNESP. Foram analisadas a participação dos alunos por meio da troca de experiências, suas notas individuas mediante avaliação formativa e trabalhos finais em grupo. As análises mostram que os alunos tiveram um bom desempenho e a Aprendizagem Baseada em Problemas apresenta potencial para ser usado como um método de aprendizado em cursos de estatística inferencial para melhorar as habilidades dos estudantes. Estes resultados se aproximam dos achados de estudos realizadas em outros contextos de ensino para diversas áreas de Matemática.
O uso do celular como recurso didático no ensino de geometria para alunos do ensino fundamental
Authors: Sousa Romário Araújo de , Carneiro Rogerio dos Santos , Carneiro Raylson dos Santos
Published: March 2020

O smartfone tornou-se acessível ao público jovem, que o apropriou como ambiente digital no meio escolar. Diante dessa realidade, uma possível solução para os problemas enfrentados pelo uso exagerado do aparelho celular é adequar essa ferramenta ao ensino. Em decorrência disso, a questão que norteou o embasamento teórico, a vivencia prática, a exação dos dados e análise com desenrolar desta pesquisa foi: é possível utilizar o celular/smartfone, como recurso didático nas aulas de matemática, em especial no ensino de geometria para alunos do 6° ano do Ensino Fundamental?. Este trabalho teve o objetivo de propor uma sequência didática com o intuito de estimular uma reflexão nos discentes, quanto a possibilidade da utilização do celular, com o software GeoGebra, como uma ferramenta didática no ensino de matemática. Disposemos do método de pesquisa qualitativa, que nos interessou a compreender e interpretar na produção de conhecimento, os resultados apontam que, o celular pode ser utilizado como ferramenta didática em sala de aula, e pode ser considerado um grande aliado dos professores para contribuir e motivar a aprendizagem da matemática escolar.
Aproximações e distanciamentos dos conceitos de gás e vapor nos livros didáticos de química aprovados no PNLEM 2018
Authors: Costa Jaqueline Da Silva , Lima João Paulo Mendonça , Sarmento Victor Hugo Vitorino
Published: March 2020

O livro didático tem sido a principal ferramenta utilizada na preparação e execução das aulas, funcionando como guia curricular para discentes e docentes. Em virtude disso, esse material deve ser constantemente analisado. Um dos assuntos da matriz curricular de Química que pode ser analisado é o de gás e vapor. Estes termos já foram confundidos como sinônimos, mas atualmente sabe-se que possuem diferenças. Com isso, o presente trabalho teve por objetivo analisar os distanciamentos e aproximações dos conceitos de gás e vapor nos livros didáticos aprovados no Programa Nacional do Livro didático para o Ensino Médio 2018 (PNLEM 2018) em relação à Ciência de Referência (estudos de Thomas Andrews). Utilizando a ferramenta de análise proposta por Franzolin (2007) observou-se que dos seis livros aprovados no PNLEM 2018, apenas três trouxeram essa discussão. Esses três livros aproximaram-se do referencial adotado. Além disso, foi possível associar a ausência dessa discussão em alguns dos livros analisados em virtude da escassez dessa abordagem nos livros de Ensino Superior, visto que estes são referência na elaboração do material didático do Ensino Básico. Sendo assim, por meio deste trabalho, destacou-se a importância do profissional da educação em identificar as potencialidades e limitações do livro didático.

Palavras-Chave: Livro didático, Ensino de Química, Gás e vapor.
A ênfase da linguagem na Educação Matemática: das palavras incertas às palavras com sentido
Authors: Abreu da Silveira Marisa Rosâni
Published: March 2020

Este texto tem o objetivo de discutir o papel das explicações e exemplos no ensino da matemática que acontecem em meio à utilização de normas e descrições. Mesmo que nossa sugestão seja a ênfase da linguagem na educação matemática, reconhecemos a vagueza de nossa linguagem ordinária. A busca de palavras com sentido para evitar palavras incertas pode ser a meta do educador que é atento à linguagem na sua prática docente e assim, privilegia a escuta da voz do aluno para compreender aquilo que foi interpretado por meio de suas explicações. Neste sentido, nos amparamos na filosofia da linguagem de Wittgenstein, mais especificamente no seu segundo momento filosófico, bem como em alguns de seus comentadores e educadores matemáticos que se apóiam em sua filosofia.
Função polinomial do 2° grau: uma sequência didática apoiada nas tecnologias digitais e na robótica
Authors: Casagrande Emília , Sandini Trentin Marco Antônio
Published: March 2020

Esse artigo relata a aplicação de uma sequência didática sobre o conteúdo função polinomial do 2° grau utilizando-se de diferentes recursos tecnológicos, averiguando sua pertinência em termos de favorecer a participação dos estudantes em uma aprendizagem mais efetiva na disciplina de matemática. Tal sequência didática foi estruturada em cinco encontros, nos quais o estudo da função polinomial do 2° grau foi abordado utilizando-se de aparatos tecnológicos, softwares e simuladores. Ao final, foi possível inferir que o uso de diferentes recursos tecnológicos em aulas de Matemática pode contribuir para o aprendizado dessa disciplina, permitindo aos alunos manipular, interagir, visualizar, verificar, refletir e construir situações que os auxiliem no processo de construção do conhecimento, tornando assim, as aulas mais dinâmicas, participativas e significativas.
TÜRKİYE ÖZEL GÜVENLİK SEKTÖRÜNE DÖNÜK YENİ BİR HİZMET STRATEJİSİ
Authors: ALPKUTLU Menderes
Published: March 2020

Bu
çalışma, güvenlik disiplinine ilişkin nitel bir konuyu içermektedir. Çalışmada,
konuya içkin literatür birikimi, özel güvenlik bileşenleri
(işveren-yönetici-özel güvenlik personeli) ile halktan oluşan 434 katılımcıyla
gerçekleştirilmiş yarı yapılandırılmış mülakat verileri ve basın-yayın
kanallarına yansıyan demeçlerden yararlanılmıştır. Sürecin amacı ve ilişkili
hedefleri ise hizmetin içinde olduğu sorunlu bazı başlıklara tahsis edilmiştir.
Bu başlıklar; sektörün iç güvenlikteki pozisyonu, sermaye ve ücret bağlamındaki
algısı, reel olmayan istihdam ayrışması, teröre dönük rolü, eğitim çeşitliliği
ile uygulamadaki uyuşmazlık, disiplin ve denetim yetersizliği, güvenlik
felsefesiyle uyuşmayan üniforma çeşitliği ve negatif özel güvenlik imajı
şeklide sıralanabilir. Sonuç olarak, bu çerçevede özel güvenlik sorunsalına
dönük ortaya konulan tespitlerle yeni bir özel güvenlik stratejisinin kapısı
aralanmaya çalışılmaktadır.
GÜVENLİK İHRACI BAĞLAMINDA TÜRKİYE’NİN ÖZEL ASKERÎ-GÜVENLİK SİSTEMİ
Authors: ALPKUTLU Menderes
Published: March 2020

Yeni bin yılın dünyası da insan ve devlete ait değerleri hedef alan çok çeşitli risk, tehdit ve tehlike halleriyle dikkat çekmektedir. Hatta bugün, neredeyse hiçbir mekân ve zaman diliminin yüzde yüz güven vermediği, anlık yöntem değiştiren bir güvenlik örüntüsü öne çıkmaktadır. Bu hassasiyetin neticesi olan analitik bu çalışma, önalıcı güvenlik (preemptive) paradigmasıyla, Türkiye özel güvenlik uygulamasının sabiteleri üzerinden marka değeri yükseltilmiş askerî şirket yapılanmasını tartışmaktadır. Konunun alt başlıkları ise güvenlik olgusu ile Türkiye’nin bu sisteme eklemlenme mazisi ve günceline tahsis edilmiştir. Yöntem boyutuyla makale, ulusal ve uluslararası nitel çalışmalar üzerinden, Türkiye’nin teorik güvenlik havuzuna katkıyı önceleyen bir misyon ve tümdengelim metodunu içeren bir vizyonla şekillenmektedir. Bu yolda beliren taktik hedefler aracılığıyla da özel askerî şirketleşmenin avantajlarına ilişkin bir temaya odaklanılmaktadır. Böylece, faaliyet gösteren iki özel askerî şirket örneği üzerinden sektörün profesyonel bir yaklaşımla yapılandırılmasının Türkiye’nin önalıcı ulusal güvenliğini tamamlayacağı tezi temellendirilmeye çalışılmaktadır.          
SOĞUK SAVAŞ SONRASI RUSYA FEDERASYONU İÇ GÜVENLİK BİRİMLERİ
Authors: İÇEN Ahmet Burak
Published: March 2020

Bu

makalede Soğuk Savaş sonrası modern Rusya’nın iç güvenlik aktörleri ayrı ayrı

incelenmiş, yapısal ve kurumsal özellikleri haricinde daha anlaşılabilir olması

adına ülkemiz muadil kurumlarıyla karşılaştırmaları yapılmıştır. Rusya

Federasyonu kapladığı milyonlarca kilometrekare toprağı ve bu topraklar

içerisinde yaşayan çok çeşitli halkları ile zor ve büyük bir coğrafyada iç

güvenlik ve iç asayişi sağlamaya çalışmaktadır. Böylesine farklı halkları bir

arada geniş bir coğrafyada barındırmak örgütsel ve mali olarak oldukça zor bir

iş haline gelmiş, soğuk savaş sonrası Sovyetler Birliğinin yıkılması üzerine

temelinden sarsılan düzen, yeni bir devlet anlayışı içerisinde yapılanma

zorunluluğu getirmiştir. İç karışıklıklar ve ekonomik buhranlar yapılanmanın

yavaşlamasına neden olmuş, iç güvenlik sorunu uzun yıllar boyunca Rusya’nın en

önemli sorunu olmuştur. Putin dönemine kadar yeniden yapılanma ile rol model

kapsamında yetersiz kalınmış ve Sovyetler geleneği hissedilmeye devam etmiştir.

Ancak Putin dönemi ile Çarlık Rusya’sı devlet düzeni incelenmiş ve Çarlık

Rusyası-Sovyetler sentezi ile kendine özgü bir iç güvenlik anlayışı ve bu

anlayış üzerine yapılanan kurumlar ortaya çıkmıştır. Makalede, yeniden

yapılanan iç güvenlik organlarının yapısal, işlevsel yönleri ele alınmış,

Türkiye’deki muadilleri ile karşılaştırılması amaçlanmıştır.
Epileptic Focus Localization Based on iEEG Plot Images by Using Convolutional Neural Network
Authors: Zhao Xuyang , Sui Linfeng , Tanaka Toshihisa , Cao Jianting , Zhao Qibin
Published: March 2020

Patients with epilepsy need to locate the lesion before surgery. Currently, clinical experts diagnose the lesions through visual judgment. In order to reduce the workload of clinical experts, many automatic diagnostic methods have been proposed. Usually, the automatic diagnostic methods often use only one feature as the basis for diagnosis, which has certain limitations. In this paper, we use multiple feature fusion methods for automatic diagnosis. For the cause of epilepsy: abnormal discharge, we use the filter and entropy to capture the energy features of epilepsy discharge. Due to the epilepsy brain waves contain spike and shape waveforms, short time Fourier transform (STFT) is used to analysis the time-frequency features. In feature fusion, we plot the color map of entropy and spectrogram get from STFT together to combine the different types of features. After the feature extraction and fusion steps, each brain signal is converted into an image. Next, we use the visual analysis capabilities of the convolutional neural network (CNN) to classify the plot image. With the visual recognition ability of CNN, in the experiment, we got a classification accuracy of 88.77%. By using automatic diagnostic methods, the workload of clinical experts is greatly reduced in actual clinical practice.
Co-expression networks uncover regulation of splicing and transcription markers of disease
Authors: Zhang Pan , Southey Bruce , Rodriguez-Zas Sandra
Published: March 2020

Gene co-expression networks based on gene expression data are usually used to capture biologically significant patterns, enabling the discovery of biomarkers and interpretation of regulatory relationships. However, the coordination of numerous splicing changes within and across genes can exert a substantial impact on the function of these genes. This is particularly impactful in studies of the properties of the nervous system, which can be masked in the networks that only assess the correlation between gene expression levels. A bioinformatics approach was developed to uncover the role of alternative splicing and associated transcriptional networks using RNA-seq profiles. Data from 40 samples, including control and two treatments associated with sensitivity to stimuli across two central nervous system regions that can present differential splicing, were explored. The gene expression and relative isoform levels were integrated into a transcriptome-wide matrix, and then Graphical Lasso was applied to capture the interactions between genes and isoforms. Next, functional enrichment analysis enabled the discovery of pathways dysregulated at the isoform or gene levels and the interpretation of these interactions within a central nervous region. In addition, a Bayesian biclustering strategy was used to reconstruct treatment-specific networks from gene expression profile, allowing the identification of hub molecules and visualization of highly connected modules of isoforms and genes in specific conditions. Our bioinformatics approach can offer comparable insights into the discovery of biomarkers and therapeutic targets for a wide range of diseases and conditions.
Virtual Experimentation Complements Real-World Experimentation
Authors: Smith Andrew , Ropella Glen , Hunt C. Anthony
Published: March 2020

Studying biological systems is difficult because of complexity, variability, and uncertainty. Conceptual models and diagrams are useful in conveying ideas about how a biological phenomenon are thought to be generated. However, sophisticated modeling and simulation methods are needed to discover mechanism-based explanations. Presented herein is a new and unique methodology for this application. Using virtual experiment methods, we recently provided a plausible solution to a problem that had eluded and perplexed pharmacologists and toxicologists for more than 40 years. We describe how virtual and real-world experimentation can be complementary, and propose a way to partially automate the methodology to expedite research.
In silico library design, screening and MD simulation of COX-2 inhibitors for anticancer activity
Authors: Sahu Ankita , Pradhan Dibyabhaba , Raza Khalid , Qazi Sahar , Jain A K , Verma Saurabh
Published: March 2020

Health problems are increasing worldwide pertaining to cancer modalities.

Cyclooxygenase enzyme is known to be involved in cancer biology, neurological disorders, cardiovascular and other diseases. It has been a promising target for developing novel anti-inflammatory drugs in breast cancer treatment. Hence, a computer-aided drug design strategy was applied to identify potent inhibitors of the COX-2 receptor. For this purpose, 12084 ligands from different databases to be tested based on similarity search criteria and were docked against our target protein COX-2 retrieved from the protein data bank. The high-throughput virtual screening protocol was performed and examined the compounds for its binding free energies. Eleven compounds were found out with better binding affinity by virtual screening results and showed interaction with the protein at the known active site. The selected compounds filtered through the Lipinski’s rule of five. The physicochemical properties and bioactivity scores were calculated. Molecular docking calculations, MD simulations, ADMET properties, and protein-ligand interaction were analyzed to determine the suitability of each ligand. Overall, the results from our study suggest that compound ZINC000039428234 could be a potent inhibitor for the COX-2 protein of breast cancer. We look forward to this result is of the enormous key in designing a potential drug candidate for breast cancer.
Organophosphorus compounds: a hidden threat to the health and wellbeing of mankind
Authors: Gorbunov Konstantin , Gudkov Denis
Published: March 2020

Organophosphorus compounds (OPC) have been known for about 90 years: drugs and pesticides, poisons causing paralysis, convulsions and death in case of acute poisoning and leading to cancer, malformations and cognitive impairment in case of chronic exposure by doses that do not cause acute intoxication. Despite the existing measures, deaths due to OPC poisoning are recorded annually. The problem of children development after any poisoning even with small doses of these substances is especially urgent. Modern technologies provide new perspectives for the analysis of chronic intoxication by OPC, prognosis of acute poisoning severity and long-term health consequences. Research of miRNA and metabolomics came to the first place among the scientific approaches to the study of the body’s response to various external stimuli, including OPC poisoning. New methods are being developed to prevent the effects of poisoning based on stabilized bacterial enzymes, as well as modified miRNA.
Study and modeling of mechanisms of cholinesterasis reactions in order to improve their catalytic properties in the neutralization reactions of organophosphorus compounds
Authors: Varfolomeev Sergey , Grigorenko Bella , Lushchekina Sofya , Masson Patrick , Mahaeva Galina , Novichkova Dana , Nemuchin Alexander
Published: March 2020

“Biocleaners” or “bioscavengers” are biological objects (enzymes, catalytic antibodies) that are capable of binding and/or hydrolyzing organophosphorus compounds (OPC). Their use seems to be the most effective alternative to traditional antidotes to neutralize or detoxify OPC. The introduction of bioscavengers allows neutralizing toxicant molecules in the bloodstream before they reach their biological targets, thereby providing protection against poisoning. Bioscavengers of the first-generation neutralized OPC molecules by stoichiometrically binding to them. The safety and efficacy of human butyrylcholinesterase (BChE) for protecting against OPC poisoning has been shown. However, the stoichiometric neutralization of OPC requires the introduction of a huge amount of expensive biopharmaceuticals. Catalytic bioscavengers that hydrolytically neutralize OPC were introduced at a much lower dose to achieve the same degree of effectiveness. The most effective catalytic bioscavengers are enzymes. The most promising enzymes are artificial mammalian paraoxonase mutants and bacterial phosphotriesterases. However, studies of other enzymes, such as prolidases, oxidases, artificial mutants of cholinesterases and carboxyl esterases and catalytic antibodies are actively ongoing. Since OPC are pseudosubstrates of cholinesterases (ChEs), a detailed description of the mechanisms of inhibition, dealkylation, and spontaneous reactivation of phosphorylated ChEs is critical for the development of ChEs mutants with a high rate of hydrolysis of OPC. The review presents an analysis of different views on the mechanisms of interaction of ChEs with OPC, discusses the possible directions of creating effective catalytic biological traps based on BChE and changes in their mechanism of action as compared to the native enzyme. A separate section is devoted to the effect of mutations, both polymorphic and artificial, on the stability of the protein molecule of BChE.
Bioanalytical systems based on cholinesterases for detection of organophosphates
Authors: Eremenko Arkadiy , Kurochkin Il'ya , Nechaeva Nataliya
Published: March 2020

Various types of electrochemical sensors based on the inhibition of butyrylcholinesterase (BChE) have been presented for the analysis of organophosphates (OPC). A special design of thick film sensors and electrochemical detector for cholinesterases assay and their inhibitors in aqueous samples has been developed. For this assay, thiol sensitive sensors based on screen printed graphite electrode modified with nanoparticles of manganese dioxide were used. High sensitivity of manganese dioxide modified thick film sensors towards thiocholine and therefore low detection limit of BChE (1 pM) enabled their use for subnanomolar detection of an organophosphate pesticide diazinon, and other irreversible inhibitors of BChE. This work also presents modern innovative approach for the analysis of BChE by Raman spectroscopy. New SERS-substrates based on silver paste for sensitive quantification of BChE activity were obtained, characterized and applied to thiocholine detection, with LOD (TCh) being 260 nM. Real samples of human plasma were analyzed; a good correlation between spectrophotometric detection and Raman detection was shown. The developed technique is inexpensive and easy-to-use and has promising potential for analysis of OPC.
Catabolism of organophosphonates: biochemistry, physiology and interactions of degrading bacteria in the environment
Authors: Ermakova Inna , Leontievsky Alexey , Sviridov Alexey , Shushkova Tatyana , Epiktetov Dmitriy
Published: March 2020

The major contribution of microorganisms in metabolism of natural and synthetic phosphonates, the biochemical bases of these processes and possible interactions between degrading bacteria in natural and anthropogenic ecosystems are presented in the light of the recent data on significant role of reduced phosphorus compounds in the biosphere. Special emphasis is placed on C-P lyase and phosphonatase which are pivotal enzyme systems for catabolism of both natural and synthetic phosphonates. Modern data on structure, diversity, regulation and physiological role of both enzymes are reviewed and discussed.
Propulsion System Design For The Indonesian Semi High Speed Train
Authors: Shalahuddin Lukman , Putranto Kartiko E. , Eskayudha Dimas B.
Published: March 2020

This paper describes a study on the development of methodology to select the most appropriate technology, and the most optimum design and configuration for the propulsion system of the semi-high speed intercity train that will be operated on the Jakarta-Surabaya corridor. It also describes the method to calculate resistance loads Â and tractive forces and hence the power required to propel the train along the specified route within targeted time. Among the output of this study is a recommendation for the most optimum propulsion system with basic/ main parameters for main components such as diesel engine, traction motor and the possibility of Diesel Electric Multiple Unit (DEMU) Hybrid battery system.
Pemberdayaan Kelompok Setia Kawan dalam Produksi Garam Beryodium di Desa Labuhan Bajo, Sumbawa
Authors: Syafikri Dedi , Mardhia Dwi , Yahya Fahmi , Andriyani Nining
Published: March 2020

Labuhan Bajo Village is one of the villages designated as a center for the development of community salt in Sumbawa Regency. Problem related to salt encountered in Labuhan Bajo Village is the low income of the salt farmers group, there is still need to increase the quality and quantity of salt production and the absence of iodized salt production. The other problem is related to iodine deficiency (IDD), such as the stunting case, which is need to be handled immediately, considering that Labuhan Bajo Village is one of the villages in Utan Subdistrict which has a high stunted prevalence (22.1%). Therefore this service is expected to be a solution for the availability of iodized salt production in Sumbawa, especially in Labuhan Bajo Village while contributing to stunted prevention. The aim of this service activity is to assist Setia Kawan group in increasing the quantity and quality of salt to KW 1 and producing iodized salt that meets SNI requirements. The method for carrying out this community service activity includes counseling, training, assistance in procurement of equipment and assistance. The results of this activity are the availability of salt processing technology using the TUF + Iodization method, increasing the amount of salt production by the Setia Kawan Group, the availability of KW 1 salt and iodized, increasing the income of the Setia Kawan group, increasing the marketing network and increasing the knowledge and skills of salt farmers in applying TUF + Iodization method.
The Resilience and Agricultural Household Livelihood Strategies of the 2018 Lombok Earthquake Victims at the Emergency Period in North Lombok Regency
Authors: Nurjihadi Muhammad
Published: March 2020

A great earthquake was hitting Lombok in August 2018 that caused damage to home and livelihood sources of almost 100% of North Lombok Regency (KLU) population. This research is aimed to investigate the resilience capacity and livelihood strategies of displaced people (the earthquake victims) of KLU, especially the agricultural families during the post disaster emergency period. This research is using mix method between qualitative and quantitative approaches that explained descriptively. The qualitative data in this research was obtained using purposive area snowball sampling technique while the quantitative data was obtained through a comprehensive survey using Displacement Tracking Matrix (DTM) technique. Result of the research revealed that the earthquake caused the lost of jobs and livelihood sources of KLU’s people in all economic sectors, including agricultural sector. Social capital of the society was influencial as a main strategy of the victims to fulfil their daily needs and strengthen their social resilience in facing the damaging impact of the disaster. By exploiting their social capital, the society was able to fulfil their daily needs by managing all external aids, natural resources, and their remaining personal assets based on their common understanding, local wisdom, and social norms that exist in the society.
Epizodisták főszerepben – a szenvedélybetegek testvérei
Authors: Gyárfás Anikó
Published: March 2020

A tanulmány a szenvedélybetegek testvéreivel foglalkozik. A szakirodalmi áttekintés alapján a szenvedélybetegek szüleiről, párjukról sok kutatás készült, testvéreikről viszont kevés. A tanulmány célja ennek a hiánynak a pótlása. A kutatás során a Kék Pont Alapítvány szerhasználók testvérei számára szervezett csoportjából öt, továbbá egy, nem csoporttag testvérrel készítettem félig strukturált interjút. Az interjúkat irányított tematikus elemzéssel dolgoztam fel.

Eredmények: a testvérek családon belüli kapcsolatait negatívan befolyásolja hozzátartozójuk szerhasználata. A testvérek a droghasználatot minden esetben jóval előbb tudják, mint a szülők. Túlzott felelősséget vállalnak szerhasználó hozzátartozójuk megmentéséért. A testvérek iskolai, munkahelyi teljesítményét, mindennapi helytállását kedvezőtlenül befolyásolta hozzátartozójuk szerfüggősége.

Következtetések: fel kívánom hívni a szakemberek és a szülők figyelmét arra, hogy a nem szerhasználó testvérek számára is nyújtsanak segítséget.
O debate teológico sobre as conferências episcopais após a promulgação do Código de Direito Canônico de 1983
Authors: Andrade Paulo Fernando Carneiro de
Published: March 2020

O A. apresenta o debate teológico sobre as Conferências Episcopais no tempo compreendido entre a promulgação do atual Código de Direito Canônico (1983) e nossos dias. Opta por uma apresentação diacrônica do debate, buscando destacar os momentos mais significativos do mesmo ao longo destes anos. Procura, para maior clareza, destacar entre as diversas questões presentes neste debate teológico três principais: a) a fundamentação teológica das Conferências Episcopais; b) a possibilidade de estas exercerem um múnus magisterial: c) a pertinência de aplicar-se à Igreja o princípio de subsidiariedade.Abstract: The Author presents the theological debate on the Episcopal Conferences in the time contained within the pontulgation of the present Canonical Code of Law (1983) and our days. Here opts for a diacronical presentation of the debate, trying to bring out the most significant moments of it as these years have gone for greater clarity, he tries to pay greater attention to three principal ones among the many questions present in this theological debate: a) the theological foundation of the Episcopal Conferences; b) the possibility that these exercise a teaching office; c) the pertinence of applying the principal of being subsidiary to the Church.
Problemas epistemológicos de la valoración en contabilidad
Authors: Peña Aura Elena , Maldonado Veloza Fabio , Viloria Ortega Norka Judith , Casal Peraza de Altuve Rosa Aura
Published: March 2020

Uno de los pilares donde descansa la actividad contable es suponer que la realidad que representa la contabilidad es independiente del contador, por lo que él registra las cosas en tanto son. Los organismos reguladores, por su parte, suponen que la información es neutral y, por tanto, no reflejan el sesgo del contador, pero no consideran que al normar a través de reglas que permiten el juicio profesional, la información deja de ser neutral. La valoración en contabilidad es uno de los aspectos en los cuales el juicio profesional tiene mayor trascendencia, debido a que es su trabajo consuetudinario la asignación de valor a las transacciones de la orga- nización. Algunos problemas cruciales de la valoración se relacionan con la estabilidad monetaria, el determinismo, el estatismo (de estático), la volatilidad de las estimaciones, la inobservabilidad y la no verificabilidad. Estos problemas de índole epistemológica no son de re- ciente data, y se requiere de una seria discusión desde distintas posturas de la realidad para lograr evolucionar de este estado del arte.
Contabilidad: responsabilidad social - gestión humana
Authors: Jiménez Aguirre Rubiela
Published: March 2020

El documento presenta algunos elementos de análisis sobre la forma en que las empresas asumen la responsabilidad social. De la manera como se asume la responsabilidad social, depende, en buena medida, la gestión humana. Así mismo, se plantean algunos de los modelos que se han hecho presentes en la literatura sobre la “medición” del talento humano y, también, se plantea la reflexión a partir de la investigación realizada en términos de la relación de la contabilidad con la gestión humana en la perspectiva interna de la responsabilidad social
Aproximación metodológica alternativa para la determinación del valor razonable de bienes que no cuentan con mercado primario caso: maquinaria usada en construcción
Authors: Serna Restrepo Jairo , Rojas Medina Ricardo Alfredo
Published: March 2020

El presente trabajo plantea una metodología para realizar estudios tendientes a determinar el valor razonable de las propiedades planta y equipo que no cuentan con un mercado primario, y que, al tenor de la NIIF 13 (Valor razonable), solamente pueden contar con datos de entrada de nivel 3. La metodología propuesta parte del costo histórico de los bienes que conforman las propiedades planta y equipo, este valor es re expresado a valores actuales con el empleo del índice de precios al consumidor; luego, con el uso del modelo de probabilidad exponencial se establece la vida probable que le queda al bien, cifra que es multiplicada por el valor re expresado obteniendo así el valor actual. Este proceso es simulado un millón de veces y los valores obtenidos son resumidos y presentados en una distribución en la que se ubica el valor y el porcentaje de observaciones que supera, dando así origen a los valores máximos para una probabilidad dada.
Guía para la administración del riesgo empresarial, una herramienta práctica para el revisor fiscal en Colombia
Authors: Sandoval Ortega Ernesto
Published: March 2020

Este artículo ilustra el contenido de una guía para la administración de riesgos, la guía está diseñada para ser implementada en empresas privadas del sector real, donde el Revisor Fiscal vigilará su cumplimiento y también la utilizará para su beneficio poniéndola en práctica en el desarrollo de sus labores, es decir, que la Guía para la administración del riesgo empresarial, puede servir de orientación y buena práctica para las empresas, y también puede servir de herramienta para el control que ejerce el Revisor Fiscal. La guía se desarrolla con base en la conceptualización y propuestas teóricas de riesgos que deben ser llevadas a la práctica del control, la metodología estructurada paso a paso de la guía y el manejo del mismo lenguaje en función de riesgos, construye una estrecha relación entre los objetivos de control de la empresa y los objetivos de control del Revisor Fiscal, finalmente la guía propone acciones para el manejo y control de los riesgos corporativos.
Virtual Illusion: Comparing Student Achievement and Teacher and Classroom Characteristics in Online and Brick-and-Mortar Charter Schools
Authors: Fitzpatrick Brian R. , Berends Mark , Ferrare Joseph J. , Waddington R. Joseph
Published: March 2020

As researchers continue to examine the growing number of charter schools in the United States, they have focused attention on the significant heterogeneity of charter effects on student achievement. Our article contributes to this agenda by examining the achievement effects of virtual charter schools vis-à-vis brick-and-mortar charters and traditional public schools and whether characteristics of teachers and classrooms explain the observed impacts. We found that students who switched to virtual charter schools experienced large, negative effects on mathematics and English/language arts achievement that persisted over time and that these effects could not be explained by observed teacher or classroom characteristics.