bluuebunny/crossref_metadata_2025 huggingface dataset:
Functional Analysis of BrUFO in Chinese Cabbage in Response to Plasmodiophora Brassicae
Authors: Zhang Bo , Feng Hui , Ge Wenjie , Wang Xinlei , Zhang Jing , Ji Ruiqin
Published: March 2022

Chinese cabbage is one of the most important vegetable crops in China. However, the yield is seriously affected by clubroot disease, caused by infection with Plasmodiophora brassicae . In our previous study, the Bra039878 protein was found to be significantly upregulated in diseased roots of Chinese cabbage after inoculation with P . brassicae . Herein, to explore its function, a full-length cDNA of BrUFO was cloned and analysed. The results revealed high homology with Arabidopsis UNUSUAL FLORAL ORGANS ( UFO ), hence we named it BrUFO . Quantitative real-time polymerase chain reactions (qRT-PCR) and in situ hybridisation analysis showed that expression of BrUFO was lower in the resistant plants than in susceptible plants, suggesting that BrUFO is related to resistance to clubroot disease. Subcellular localisation analysis showed that BrUFO was expressed in the nucleus. Virus-induced gene silencing (VIGS) analysis showed that silencing of BrUFO reduced the incidence of clubroot disease. Six proteins interacting with BrUFO were screened by Y2H assay, and two ( Bra038955 and Bra021273 ) were confirmed to strongly interact with BrUFO by Y2H point-to-point verification. Bra038955 is a GDSL-motif esterase/acyltransferase/lipase, but the function of Bra021273 is unknown. Thus, BrUFO may play a key role in regulating disease resistance to clubroot by interacting with GDSL .
Chronic Pre-Treatment of Kombucha Tea Protects Brain Injury induced by Ischemia/Reperfusion in Global Brain Ischemia
Authors: Mesgari-Abbasi Mehran , Vaezi Fatemeh Eskandari , Hossienzadeh Fezzeh
Published: March 2022

Cerebral ischemia is an important factor in developing neurological damage without appropriate medical treatment. Kombucha tea(KT) is a fermented beverage that produces many compounds with antioxidant power with potential health effects. This study was performed to evaluate the effect of pre-treatment of kombucha tea on brain edema, neurobehavioral, and oxidative stress in the global brain ischemia model. Adult male Wistar rats were divided into four groups include; the sham, the ischemic, and the KT-treated-ischemic groups. KT was administrated two weeks before inducing transient global cerebral ischemia at two different dosages (one and two ml/kg/day, gavage). The global brain ischemia was induced by blocking the common carotid arteries for one hour, followed by 24 hours of reperfusion. At the end of reperfusion, neurobehavioral studies were done. Brain edema was determined by dry-wet methods. Malondialdehyde (MDA), total antioxidant capacity (TAC), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) levels were measured in the serum and the brain tissue. Our results showed that pre-treatment of KT significantly reduced brain edema and MDA levels in the blood and the brain. It significantly increased the total TAC and GPx levels in the blood and the brain in ischemic rats treated with KT. The CAT activity significantly increased in the blood, but it didn’t significantly change the brain. KT of pre-treatment significantly ameliorated neurobehavioral defects in the ischemic rats. Our data demonstrated that pre-treatment of KT maybe protect the brain against ischemic-reperfusion injury through a decrease in the production of lipid peroxidation and an increase in the capacity of antioxidants defense.
A Comparative Study of Centralized and Distributed Battery Approach in Multi-Energy Harvesting System for UWSN
Authors: Saleem Azizullah , Akkan Taner , Akkan L. Ozlem Karaca
Published: March 2022

Underwater sensor network (UWSNs) has sensors and mobile wireless transceivers deployed in under and upper water areas to perform data monitoring and acquisitions. With the emerging technologies UWSNs has many different specific underwater applications. But there are problems and challenges facing underwater environment such as propagation delays, energy limitation, narrow bandwidth, and node mobility. Various protocols have been developed to deal with these issues. Energy consumption is one of the main problems in underwater wireless sensor network as the nodes’ batteries have limited amount of energy. Furthermore, batteries cannot be replaced easily as replacement cost is very high and batteries have high weight. To solve energy consumption problem, firstly multi power harvesting system is developed and optimized using genetic optimization, followed by design of wireless sensor nodes battery energy level model based on multi energy harvested system and its application to centralized and distributed system is investigated and finally followed by discussion and conclusion.
Alpha, Beta, and Gamma Oscillations in Cortical Communication During Motor Preparation
Authors: Zhao Yun , Wilkins Kevin , Yao Jun
Published: March 2022

Motor cortices prepare movements by rotating activity from one region into another via synchronized firing at different frequencies, primarily involving α, β and γ bands. Previous results in non-disabled participants showed that although within β-band couplings in contralateral motor cortices dominant cortical activities for hand opening task, α-β and γ-β couplings are presented for more complex tasks. These findings raise the question whether α and γ bands play a modulation role on the β-oscillation during the motor preparation for an “un-established” task. To test this question, we compared the cortico-cortical-communication during motor preparation for hand opening between the non-disabled and stroke groups. Twelve stroke individuals who cannot open hand sufficiently and eleven age-matched non-disabled individuals performed a maximal hand opening with a high-density EEG measure. The non-disabled group expressed the exclusive within-β communications primarily within contralateral motor areas. Differently, the stroke group showed complex couplings across both hemispheres involving α, β and Gamma bands. These findings suggest that a cortical preparatory β communication may reflect using a well-established internal model. However, when the internal model does not work sufficiently, bilateral α and γ-band modulation to the β oscillation occurs, demonstrating the learning and adjustment to the motor plan.
Tick borne microbial agents in Iran and the adjacent countries: A meta- analysis based on the GenBank database
Authors: Hosseini-Chegeni Asadollah
Published: March 2022

In this review study a novel approach was used while in most classical review the results of published articles are analyzed. This paper uses only microbial sequence data registered (having accession number) in the GenBank database. The results of this study play an important role in informing the public health and veterinary diagnostic systems for the entry of microbial agents through invasive infected ticks into the country through livestock and wild animals’ movement and the migratory birds.
Estimation Formula for Preparation Time of Anesthesia Induction Surgery Accounting for Clinical Department Factors in Optimal Surgery Schedule Management
Authors: Tachibana Reika , Kaneko Shohei , Yamaguchi Michiko , Fujioka Masaki , Kuroki Tamotsu , Honda Sumihisa , Sawai Terumitsu , Hara Kentaro
Published: March 2022

Background: Efficient management of the operating room is crucial, and it necessitates accurate scheduling of surgeries. We hypothesized that it would be possible to develop an estimation formula for the preparation time of anesthesia induction surgery by incorporating not only the anesthesia factors and the surgical factors, but also “clinical department” as a factor in the estimation formula.Materials and methods: This was a retrospective observational study that analyzed 7921 scheduled surgical cases. Regression analysis using clinical department, six anesthesia factors and five surgical factors was performed to develop an analysis and an equation for estimating the time required for anesthesia induction surgery.Results: Our estimation formula wielded high accuracy (R2 = 0.808). Particularly, there was only a difference of less than 3 minutes for surgeries under general anesthesia. In addition, modeling preparation time using “medical interventions performed in the operating room” as a factor instead of patient characteristics was found to be beneficial.Conclusions: It was possible to develop a highly accurate formula for estimating preparation time of anesthesia induction surgery by analyzing the anesthesia factors and the surgical factors and incorporating the clinical department as an estimation factor.
Dual Specificity Phosphatase 1 (DUSP1) Provides Mechanistic Link Between Melanoma Cellular Plasticity and Drug Resistance
Authors: Setaluri Vijayasaradhi , Singh Mithalesh K. , Altameemi Sarah , Lares Marcos , Newton Michael A.
Published: March 2022

Melanoma cells exhibit phenotypic plasticity that allows transition from a proliferative and differentiated phenotype to a more invasive and undifferentiated or transdifferentiated phenotype often also associated with drug resistance. The mechanisms involved in melanoma phenotype plasticity and its role in drug resistance are not fully understood. We previously demonstrated that the MAPK inhibitors (MAPKi)-resistance phenotype is associated with decreased expression of stem cell proliferation genes and increased expression of MAPK inactivation genes, including dual specificity phosphatases (DUSPs). Several members of the DUSP family genes, specifically DUSP1, -3, -8 and -9, are expressed in primary and metastatic melanoma cell lines and pre-and post BRAFi treated patient tumor cells. Here, we show that was knockdown of DUSP1 or DUSP8 or treatment with BCI, a pharmacological inhibitor of DUSP1/6 decreases the survival of MAPKi-resistant cells and sensitizes them to MAPKi. We also show that nestin, a neural crest stem cell marker, and MAP2, a neuronal differentiation marker, are downregulated in MAPKi-resistant cells whereas GFAP, a glial cell marker, present in both MAPKi-sensitive and -resistant cells. Inhibition of DUSP1/6 upregulated nestin expression in MAPKi-sensitive cells and cells with acquired resistance. In contrast, treatment with BCI caused upregulation of MAP2 in MAPKi-sensitive cells and downregulation of both MAP2 and GFAP in all MAPKi-resistant cell lines. These data suggest that DUSP1/6 are involved in melanoma neuronal transdifferentiation serve as mechanistic link between melanoma drug resistance and melanoma differentiation and targets for treatment of MAPKi-resistant melanoma.
Relationship between type of injured organ and development of abdominal compartment syndrome after severe blunt abdominal trauma: a nested case-control study using nationwide trauma registry in Japan
Authors: Komori Akira , Iriyama Hiroki , Kainoh Takako , Aoki Makoto , Abe Toshikazu
Published: March 2022

Background: Abdominal compartment syndrome (ACS) after blunt abdominal trauma is a rare complication that requires early recognition and subsequent surgical intervention for optimal outcome. We aimed to investigate how differences in injured abdominal organs affect ACS development in patients with severe blunt abdominal trauma.Methods: This nested case-control study used a nationwide registry of trauma patients, namely, the Japan Trauma Data Bank (JTDB), and only included patients aged ≥ 18 years with blunt severe abdominal trauma, defined as an AIS score of abdomen ≥ 3, sustained between 2004 and 2017. Patients without ACS were used as control subjects and identified using propensity score (PS) matching. Characteristics and outcomes between patients with and without ACS were compared and logistic regression was used to identify specific risk factors for ACS.Results: Among 294,274 patients in the JTDB, 11,200 were eligible for inclusion before PS matching, and 150 (1.3%) developed ACS after trauma. PS matching led to the inclusion of 131 and 655 patients with and without ACS, respectively. Compared to controls, patients with ACS had higher number of injured organs in the abdomen and displayed a greater frequency of vascular and pancreatic injuries, need for blood transfusion, and disseminated intravascular coagulopathy, a complication of ACS. In-hospital mortality was higher in patients with ACS than those without ACS (51.5% vs. 24.4%, p < 0.01). Logistic regression analysis revealed that a higher number of injured organs in the abdomen [odds ratio (OR) (95% confidence interval [CI]): 1.71 (1.22–2.40)] and pancreatic injury [OR (95% CI): 1.44 (1.03–2.03)] were independently associated with ACS.Conclusions: Greater number of injured organs in abdomen and pancreatic injury are independent risk factors for the development of ACS; injuries to other organs were not associated.
Sotrovimab neutralizing SARS-CoV-2: Risk factors for post-infusion clinical events
Authors: Yoshida Junichi , Shiraishi Kenichiro , Noda Hirotaka , Otani Kazuhiro , Kikuchi Tetsuya , Mataga Akiko , Ueno Takako , Tanaka Masao
Published: March 2022

Background Sotrovimab has been developed to neutralize SARS-CoV-2 which remained effective at the advent of B.1 lineage of the Omicron variant. To investigate post-infusion clinical events and their risk factors, we performed a retrospective study.Methods Subjects were a consecutive series of inpatients with COVID-19 undergoing an infusion of sotrovimab in our institute. In accordance with previous clinical trials, we included patients at risk but permitted SARS-CoV-2 vaccinees. For statistical analyses, we reviewed background factors of demographics, imaging, and laboratory findings for the outcome of post-infusion events such as temperature over 38 degrees Celsius (Temp38) and pulse oximetry below 94%.Results Of a total of 136 patients, the median follow-up was 47 days. Among 110 fully vaccinated patients (80.9%) for SARS-CoV-2, 2-time vaccinees accounted for 88 while 3-time vaccinees were 22. Three patients (2.2%) showed worsening of COVID-19; one developed hypoxia and two died. For the outcome of Temp38 (N=41), multivariate analysis showed that factors at risk were younger age (<66.5) (Odds Ratio [OR] 4.364, 95% Confidence Interval [CI] 1.562 – 12.194, P=0.005) and pre-infusion temperature more than 36.7 degrees Celsius (OR 7.256, 95% CI 2.695 – 21.455, P<0.001). For post-infusion reduced oximetry (N=17), symptomatic days (>2) (OR 8.657, 95% CI 1.030 – 72.786, P=0.047) and pulse oximetry (<96.5%) (OR 7.160, 95% CI 2.071 – 24.751, P=0.002) were at risk. Oxygen was supplied for a median of 1.5 days (range, 1 - 5). We observed vomiting (N=1) and elevated aminotransferase levels (N=1). Conclusions With fully vaccinated patients predominant, antibody-dependent enhancement may have brought about post-infusion fever in the younger population prone to increase antibody titers. Likewise, patients undergoing delayed infusion after symptom onset may have produced antibody, leading into respiratory distress or lowered oximetry. Limitations for this study included inherent difficulty in distinguishing AE from worsening of COVID-19. Thus for 24 hours after infusion of sotrovimab, COVID-19 patients younger than 66.5 years may have temperature elevation, indicating the need for preparation of post-infusion fever. Those undergoing infusion after 3 symptomatic days or more may develop an oximetry decrease, thus demanding pulse oximetry monitoring.
Reciprocal exchanges involving virion and complementary sense genes, the LIR and SIR between the two clones of maize streak mastrevirus result in ameliorated symptoms in maize
Authors: Edema Richard , Gordon Donald T.
Published: March 2022

A genetic analysis of maize streak mastrevirus (MSV) virulence was conducted using two infectious DNA clones derived from isolates collected in Kenya. Virulence was tested on the susceptible Pioneer hybrid 3379 using vascular puncture inoculation of kernels. Marked differences in the severity of chlorotic streaks and stunting of seedlings were associated with mild [pMSV-KL (mild)] and severe [pMSV-Km(severe)] parental infectious MSV DNA clones. To identify determinants conditioning these differences, chimeric clones were constructed from parental clones employing restriction endonuclease fragments. Clone identities were confirmed by restriction mapping. Putative virulence determinants were identified for genomic fragments encoding the replication initiator (Rep and RepA), movement (MP) and coat (CP) protein ORFs and for those containing non-coding long (LIR) and short intergenic regions (SIR). Recombinant clones containing LIRs plus the 5'–terminus of Rep/RepA (first 189 nt) ORFs from pMSV-Km(Severe) and pMSV-KL(Mild) reciprocally exchanged displayed intermediate symptoms. Complementary replacement of the Rep/RepA ORF resulted in symptoms indistinguishable from those of parental clones. The recombinant clone constructed with LIR, Rep and RepA genome sequences from pMSV-Km(Severe) and MP, CP and SIR sequences from pMSV-KL(Mild) showed significantly more severe symptoms and accumulated higher concentrations than pMSV-Km(Severe). In contrast, the reciprocal clone showed significantly milder symptoms and lower viral titers than pMSV-KL(Mild). Viral accumulation was correlated with the intensity of leaf chlorosis and the degree of plant stunting. These data support the hypothesis that MSV virulence is a polymorphic trait involving virion and complementary sense genes (LIR and SIR).
Determining Hand-harvest Parameters and Postharvest Marketability Impacts of Fresh-market Blackberries to Develop a Soft-robotic Gripper for Robotic Harvesting
Authors: Myers Andrea , Gunderman Anthony , Threlfall Renee , Chen Yue
Published: March 2022

Hand-harvesting parameters and postharvest marketability attributes of fresh-market blackberries (Rubus L. subgenus Rubus Watson) were characterized to develop a prototype for a soft-robotic gripper for robotic harvesting. A custom-made, force-sensing apparatus attached to the thumb and fingers of a person hand-harvesting blackberries was developed to quantify forces used to harvest and to identify appendages for harvesting. Four cultivars of blackberries grown in Arkansas were harvested at optimal ripeness and stored at 2 °C for 21 days to determine the impact on marketability attributes (leakage, decay, and red drupelet reversion). The forces during harvest imparted by the thumb and middle finger were greatest (0.77 N and 0.37 N, respectively), whereas the index and ring fingers used lower forces (0.16 N and 0.06 N, respectively), primarily to stabilize the blackberry. The forces applied to grab, stabilize, and harvest blackberries caused minimal marketability damage (leakage, <10%; decay, <2%; and red drupelet reversion, <8%) after postharvest storage. This project quantified harvest and postharvest parameters, allowing data-driven design of a three-prong soft-robotic gripper for harvest of fresh-market blackberries.
Turizm Talebi Kapsamındaki Lisansüstü Tezlerin Bibliyometrik Analizi (1994-2021) (Bibliometric Analysis of Postgraduate Thesis Within the Scope of Tourism Demand (1994- 2021)
Authors: Ödemiş Murat
Published: March 2022

Turizm talebi, araştırmacılar tarafından sıklıkla araştırılan turizm literatürünün önemli konuları arasındadır. Konuyla ilgili yapılan çalışmaların araştırma kalitesinin ve gelişim sürecinin dönemsel olarak incelenmesi, birçok bilimsel alan için geçerli olduğu gibi, oldukça önemli görülmektedir. Bu nedenle çalışmanın amacı, turizm talebi kapsamında 1994-2021 yılları arasında gerçekleştirilmiş olan ulusal düzeydeki yüksek lisans ve doktora tezlerinin bibliyometrik olarak analiz edilmesidir. Bu araştırmada, konuyla ilgili yapılan ulusal düzeydeki lisansüstü tezlerin çeşitli parametrelere göre incelenmesine yönelik olarak bibliyometrik analiz yönteminden yararlanılmıştır. Araştırmada ortaya çıkan sonuçlara göre, konu kapsamında üretilen yüksek lisans tez sayısının doktora tezine göre fazla olduğu ve konu olarak ise en çok turizm talebini etkileyen faktörler ve/veya turistik talep tahmini konusunun işlendiği tespit edilmiştir. Ayrıca tezlerde en fazla nicel araştırma yöntemlerinin kullanıldığı, veri toplama aracı olarak ikincil verilerden yararlanıldığı ve araştırmaların genellikle ikincil verilere dayalı veri setleri üzerinde gerçekleştirildiği ortaya çıkmıştır.
Yerel Halkın Turizm Gelişmelerini Destekleme Niyeti: Manavgat Örneği (Residents Intention to Support Tourism Development: The Case of Manavgat)
Authors: Erul Emrullah , Uslu Abdullah
Published: March 2022

Yerel halk, turizm gelişmelerinin başarısında önemli bir rol oynar. Bu noktada yerel halkın turizm gelişmelerine yönelik tutumlarını ölçmek için literatürde birçok akademisyen ekonomik ilişkilere (algıladıkları pozitif ekonomik turizm etkileri, bireysel ekonomik çıkarlar, vb.) odaklanırken, bazıları ise kişilerarası duygusal ilişkilere (bağlılık, duygular, hisler, vb.) vurgu yapmışlardır. Fakat yerel halkın turizm gelişmelerini destekleme niyetini öncüllerini araştıran bir çalışmaya hâlâ ihtiyaç vardır. Dolayısıyla bu çalışma turizm gelişmelerini destekleme niyetini belirlemek için üç farklı yapıyı birlikte kullanıp (topluluğa bağlılık, duygusal dayanışma ve sosyal değişim) parasal ve duygusal ilişkileri harmanlayarak literatürdeki boşluğu doldurmayı hedeflemektedir. Bu araştırmada yapısal eşitlik modelinden faydalanılmıştır. Elde edilen çalışma sonuçlarına göre topluluğa bağlılık ile algılanan pozitif etkileri arasında anlamlı bir ilişki yok iken, duygusal dayanışma hem algılanan pozitif etkileri hem de turizm gelişmelerine tutumsal destekleri anlamlı bir şekilde belirlediği tespit edilmiştir. Aynı zamanda duygusal dayanışma, turizm gelişmelerine tutumsal destek ve topluluğa bağlılık ile beraber turizm gelişmelerini destekleme niyetini anlamlı bir şekilde açıkladığı belirlenmiştir. Turizm otoriteleri bizim bulgularımıza başvurarak yerel halkın turizm gelişmelerini desteklerini elde etmek adına yerel halk ile turistler arasındaki dayanışmayı arttıracak turizmle ilgili daha çok etkinlik düzenleyebilir. Çalışmanın sonunda araştırmayla ilgili öneriler, sınırlılıklar ve gelecekteki çalışmalara yapılacak tavsiyeler daha detaylı bir şekilde sunulmuştur.
Gastronomi Turizmi Kapsamında Pazarlama Stratejileri: Türkiye ve Avrupa Örneği (Marketing Strategies Within the Scope of Gastronomy Tourism: Example of Turkey and Europe)
Authors: Erbay Muhammet , Sabur D. Gökçen
Published: March 2022

Turizmde önemli atılımların yaşandığı 1990’l ı yıllar itibariyle deniz-kum-güneş konseptli turizm aktiviteleri günümüzde farklı turizm trendleriyle yarış halindedir. Gastronomi turizmi ise her geçen gün yeni gelişmelerin yaşandığı bir alternatif turizm çeşididir. Gastronomi turizmi turistlerin merak edilen yerel mutfak kültürlerini yakından tanıma fırsatı elde ettikleri özel ilgi turizmidir. Bu çalışmada gastronomi turizmi ve pazarlama kavramlarının ilişkisi üzerinde durulmuştur. Gastronomi turizmi, destinasyonların cazibesinin arttıran önemli bir faktördür. Destinasyonların taşıdığı gastronomi turizmi potansiyelinin açığa çıkartılmasında, başarılı pazarlama stratejilerinin katkısı büyüktür. Destinasyon pazarlanmasında gerçekleştirilen pazarlama faaliyetleri incelenerek mevcut durumun analizi gerçekleştirilmiştir. Avrupa’da gastronomi turizmi kapsamında gerçekleştirilen pazarlama faaliyetleri araştırılmıştır. Bu bağlamda Türkiye’deki pazarlama faaliyetleri de incelenerek Avrupa’yla farklılıkları üzerine durulmuştur. Çalışma kapsamında ülkemizde gastronomi turizmine ilişkin gerçekleştirilen pazarlama faaliyetlerindeki eksikliklerin tespit edilerek geliştirilebilmesine olanak sağlaması amaçlanmıştır. Nitel yöntemin tercih edildiği çalışmada betimsel analiz tekniğinden de yararlanılmıştır. Derleme türündeki bu makalenin gelecek çalışmalara yol gösterici olacağı düşünülmektedir.
Yerel Halkın Turizme Desteğinin Şekillenmesinde Duygusal Dayanışma, Ekonomik Fayda ve Yer Aidiyetinin Rolü (The Role of the Emotional Solidarity, Economic Benefits, and the Place Attachment to Shape Residents Support for Tourism Development)
Authors: Erul Emrullah
Published: March 2022

Bu çalışmanın amacı yerel halkın turizmden elde ettiği ekonomik faydaların ve yer aidiyetlerinin turistlerle duygusal dayanışmayı nasıl etkilediği ve en nihayetinde bu duygusal dayanışma ölçeği faktörlerinin (sempatik anlayış, karşılama doğası ve duygusal yakınlık) turizm gelişmelerine desteği nasıl şekillendirdiğini saptamaktır. Çalışma verileri (n= 366) küme örneklemesi kullanarak Fredericksburg, Texas, ABD halkı ile anket uygulanarak toplanmıştır. Literatürde yerel halkın turizm gelişmelerine karşı tutumsal, niyetsel ve davranışsal desteklerini odaklanan birçok çalışma olmasına rağmen; yer aidiyeti, bireysel ekonomik faydalar ve duygusal dayanışmayı birlikte ele alarak yerel halkın turizm gelişmelerine desteğini saptamaya çalışan bir araştırmaya hala ihtiyaç vardır. Önerilen 12 hipotezden 8’i desteklenmiştir. Yapısal eşitlik modeli kullanılarak yapılan araştırma sonuçlarına göre yerel halkın yer bağımlılığı ve elde ettiği kişisel ekonomik faydalar artıkça turistler ile olan duygusal dayanışması artmaktadır. Bununla birlikte yerel halkın turistlerle olan duygusal dayanışmasını ölçen faktörlerden ikisi (sempatik anlayış & karşılama doğası) turizm gelişmelerine desteği anlamlı ve önemli bir ölçüde belirlemektedir (R2 SMC: 0.66). Araştırma sınırlılıkları ve gelecekteki çalışmalar için birtakım tavsiyeler çalışmanın sonuç kısmında sunulmuştur.
Sağlık Turizmine Yönelik Şikâyetlerin İncelenmesi: Tripadvisor Örneği (Investigation of Complaints Related to Health Tourism: The Case of Tripadvisor)
Authors: Saatcı Gencay , Tozan Büşra , Çokay Erkut Gökhan
Published: March 2022

Son yıllarda insanlar konaklama işletmelerini yalnızca tatil yapmak ve eğlenmek için değil aynı zamanda sağlık problemlerini çözmek, tedavi olmak ve doğal kaynaklardan yararlanmak amacıyla da tercih etmektedirler. Bu çalışmanın amacı, Türkiye’de sağlık turizmi hizmeti veren beş yıldızlı termal tesisleri ziyaret eden müşterilerin Tripadvisor seyahat sitesinde belirli kategorilerde yaptıkları olumsuz yorumları incelemektedir. Çalışma, sağlık turizmi hizmeti veren beş yıldızlı termal tesislere yönelik Tripadvisor’da Ocak 2013- Kasım 2021 tarihleri arasında yapılan olumsuz yorumları kapsamaktadır. Çalışmada, nitel veri yöntemlerinden içerik analizi ve betimsel analiz yöntemlerinden yararlanılmıştır. Tripadvisor üzerindeki olumsuz yorumlar incelenerek içerik analizi yöntemiyle temalara ayrılarak kategorilendirme yapılmıştır. Yapılan incelemeler sonucunda beş yıldızlı termal tesislere yönelik yapılan şikayetlerin en çok “personel, temizlik, teknik ve yemek” konularında olduğu, en az ise “yapı, buklet, etkinlik ve güvenlik” konularında olduğu tespit edilmiştir. Aynı zamanda, elde edilen bulgular sonucunda işletmelere öneriler de sunulmuştur.
Turizm ve Liderlik Konulu Makalelerin Bibliyometrik Analizi (Bibliometric Analysis of Articles on Tourism and Leadership)
Authors: Tozoğlu Burcu , Uçar Ömür
Published: March 2022

Bu çalışmanın amacı turizm ve liderlik konulu makalelerin bibliyometrik özelliklerini belirlemektir. Bu amaç doğrultusunda araştırmada R-Stüdyo yazılımı kullanılarak Scopus veri tabanından işletme yönetimi ve sosyal bilimler alanında taranan turizm ve liderlik konulu 502 makalenin bibliyometrik analizi gerçekleştirilmiştir. Makalelerin yıllık yayın sayıları, en fazla atıf alan makale, en fazla yayın yapan ve atıf alan dergiler, en fazla yayın yapan ve atıf alan yazarlar, en fazla yayın yapan ve atıf alan ülkeler, yazarların en fazla kullandığı anahtar kelimeler, makalelerde en fazla kullanılan anahtar kelimeler analiz edilmiştir. Aynı zamanda yazarların ve dergilerin ortak atıf analizi, anahtar kelime birlikte oluşum ağ analizi, ülke iş birliktelikleri analizlerini yapabilmek amacıyla sosyal ağ analizinden yararlanılmıştır. Araştırma sonucunda, Çin’in en fazla yayın yapan, atıf alan ve ülke işbirliği sağlayan ülke olduğu, en fazla yayın yapan derginin “International Journal of Contemporary Hospitality Management” olduğu en fazla atıf alan derginin “Journal of Applied Psychology” dergisi olduğu en fazla yayın yapan yazar ve en fazla atıf alan yazarın “Pablo Ruiz Palomino” olduğu, yazarların en fazla kullandığı anahtar kelimenin “dönüşümcü liderlik” ve makalelerde en fazla kullanılan anahtar kelimelerin ise “turizm işletmeciliği” olduğu sonucuna ulaşılmıştır.
Quantum Gutzwiller approach for the two-component Bose-Hubbard model
Authors: Colussi Victor , Caleffi Fabio , Menotti Chiara , Recati Alessio
Published: March 2022

We study the effects of quantum fluctuations in the two-component Bose-Hubbard model generalizing to mixtures the quantum Gutzwiller approach introduced recently in [Phys. Rev. Research 2, 033276 (2020)]. As a basis for our study, we analyze the mean-field ground-state phase diagram and spectrum of elementary excitations, with particular emphasis on the quantum phase transitions of the model. Within the quantum critical regimes, we address both the superfluid transport properties and the linear response dynamics to density and spin probes of direct experimental relevance. Crucially, we find that quantum fluctuations have a dramatic effect on the drag between the superfluid species of the system, particularly in the vicinity of the paired and antipaired phases absent in the usual one-component Bose-Hubbard model. Additionally, we analyse the contributions of quantum corrections to the one-body coherence and density/spin fluctuations from the perspective of the collective modes of the system, providing results for the few-body correlations in all the regimes of the phase diagram.
Smearing of causality by compositeness divides dispersive approaches into exact ones and precision-limited ones
Authors: Llanes-Estrada Felipe , Roldán-González Raúl
Published: March 2022

Scattering off the edge of a composite particle or finite-range interaction can precede that off its center. An effective theory treatment with pointlike particles and contact interactions must find that the scattered experimental wave is slightly advanced, in violation of causality (the fundamental underlying theory being causal).
In practice, partial-wave or other projections of multivariate amplitudes exponentially grow with Im(E), so that analyticity is not sufficient to obtain a dispersion relation for them, but only for a slightly modified function (the modified relations additionally connect different J). This can limit the precision of certain dispersive approaches to compositeness based on Cauchy's theorem.
Awareness of this may be of interest to some dispersive tests of the Standard Model with hadrons, and to unitarization methods used to extend electroweak effective theories. Interestingly, the Inverse Amplitude Method is safe (as the inverse amplitude has the opposite, convergent behavior allowing contour closure). Generically, one-dimensional sum rules such as for the photon vacuum polarization, form factors or the Adler function are not affected by this uncertainty; nor are
fixed-t dispersion relations, cleverly constructed to avoid it and whose consequences are solid.
An introduction to axions and their detection
Authors: Garcia Irastorza Igor
Published: March 2022

In these notes I try to introduce the reader to the topic of axions: their theoretical motivation and expected phenomenology, their role in astrophysics and as a dark matter candidate, and the experimental techniques to detect them. Special emphasis is made in this last point, for which a relatively updated review of worldwide efforts and future prospects is made. The material is intended as an introduction to the topic, and it was prepared as lecture notes for Les Houches summer school 2021. Abundant references are included to direct the reader to deeper insight on the different aspects of axion physics.
Physical methods of treatment in ophthalmology
Authors: Pateyuk L. S. , Drakon A. K. , Sheludchenko V. M. , Korchazhkina N. B.
Published: March 2022

The review discusses the treatment methods based on physical phenomena in clinical ophthalmology. The physical nature and treatment techniques using electric current and electromagnetic field, light and laser radiation, mechanical energy and sound waves, high and low temperature in various ocular pathologies are considered. It is noted that reliable evaluation of the effectiveness of physical treatment methods for the different diseases and pathological conditions requires the implementation of protocols that include objective testing methods of the structure and functioning of the visual system. Once the clinical effectiveness of the particular physical treatment methods and techniques is confirmed, further development and improvement of the most efficient ones becomes possible.
The relationship of clinical manifestations and ultrasound characteristics of post-traumatic eyelid scarring
Authors: Filatova I. A. , Kiseleva T. N. , Lugovkina K. V. , Shemetov S. A. , Pavlenko Y. A.
Published: March 2022

Purpose: to study the relationship between the clinical and ultrasound characteristics of post-traumatic eyelid scarring at different stages of the post-traumatic period.Materials and methods. 15 patients aged 13 to 61 (ave. 36.5 ± 12.2 years) with post-traumatic eyelid scarring were examined for the clinical characteristics of the scar by the Manchester scar scale and subjected to ultrasound gray-scale B-scan of tissues in the “Small Part” mode and echodensitometry.Results. The above measurements of patients who suffered trauma 2–3 months before the study totaled 3–4 points on the Manchester scale, while the acoustic density of scars varied from 21 to 43 conv. units (ave. 30.5 ± 5.9 conv. units). The patients whose eyelid trauma occurred 5–6 months before the study, totaled 4–5 points; and the average scar acoustic density ranged from 30 to 65 conv. units (ave. 43.5 ± 9.8 conv. units). 10–12 months after the trauma, the clinical signs of patients received 5 points whilst a comprehensive ultrasound examination yielded the acoustic density of scars varying from 43 to 84 conv. units (ave. 54.4 ± 17.6 conv. units).Сonclusion. The study revealed a direct relationship between the changes in the clinical and ultrasound characteristics of the eyelid scar tissue at different post-traumatic period stages. As the post-traumatic period continued, the scar density, its echogenicity and the displacement of the surrounding eyelid tissues was found to increase.
Taş Mastik Asfalt Karışımlarda Mermer Tozu Kullanımının Dayanıma Etkisinin Araştırılması
Authors: İZOL Elif , SARIIŞIK Ali
Published: March 2022

Doğal kaynaklarda meydana gelen hızlı tüketim gelecek kaygısına neden olmaktadır. Bu nedenle ortaya çıkan atık malzemelerin değerlendirilmesi önemli hale gelmektedir. Bu çalışmada, üstün performanslı asfalt kaplama olan Taş Mastik Asfalt (TMA) karışımına, mineral filler olarak atık mermer tozu eklenerek, Marshall tasarım prosedürü ile oluşturulan karışımların performansına ilişkin bir karşılaştırma yapılmıştır. Bunun yanı sıra alternatif filler malzemesi olarak, kalker ve atık halde ortaya çıkan mermer tozu kullanılmıştır. Asfalt karışımlarda sıklıkla kullanılan bazalt malzemesi, kaba-ince agrega ve kontrol filler olarak kullanılmıştır. Agregaların kimyasal, fiziksel ve mekanik özelliklerinin belirlenmesi için gradasyon eğrisine uygun olacak şekilde, belirli oranlarda bitüm kullanılarak Marshall stabilite deneyi yapılmıştır. Her bitüm yüzdesine sahip 3 numune olmak üzere, toplam 45 numune dökümü yapılmıştır. Optimum bitüm yüzdesinin belirlenmesinin ardından bazalt, kalker ve mermer filler malzemenin kullanıldığı numuneler, Karayolları Teknik Şartnamesine göre değerlendirilmiştir. Diğer malzemelerle benzer sonuçların elde edilmesi ile mermer tozunun taş mastik asfaltlarda alternatif filler malzemesi olarak kullanılabileceği sonucuna varılmıştır.
Çeşitli Örme Kumaşlarda Farklı Tekniklerle Gözenekliliğin Belirlenmesi ve Hava Geçirgenliği için Optimum Tekniğin Tespiti Üzerine Bir Çalışma
Authors: UYANIK Seval , MERKEPÇİ Mehmet
Published: March 2022

Geçirgenlik özellikleri kumaş gözenekliliğinden doğrudan etkilenir. Tekstil malzemelerinin gözenekliliğini belirlemek için teorik ve deneysel birçok yöntem vardır. Bu çalışma, görüntü işleme tekniği ve geometri modelleme kullanarak askılı örme kumaşların gözenekliliğini belirlemeyi ve hava geçirgenliği açısından kumaş gözenekliliğini belirlemek için hangi tekniğin daha uygun olduğunu ortaya koymayı amaçlamaktadır. Çalışma sonuçları, optik gözenekliliği belirleyen görüntü analizinin, bu yöntem sadece gözenek boyutuna odaklandığından geometri modellemeye göre daha uygun olduğunu kanıtlamıştır. Ayrıca örme kumaşlarda ilmeklerin konumuna göre gözenek boyutları değiştiği için hava geçirgenlik değerleri beklenmedik bir şekilde ilmek sayısı ile paralel değildir..
İnce Numara Kompakt İpliklerin Katlama-Bükümünde Hamel Büküm (Elasto-Twist) Teknolojisinin Kullanımı ve İplik Özellikleri
Authors: ŞAHİN Mehmet , BABAARSLAN Osman
Published: March 2022

Tekstil sektörünün ana hammaddesi olan iplik, tek kat olarak üretildiğinde bazı fiziksel özellikleri sınırlı kalabilmektedir. Ayrıca değişen ve gelişen nihai ürün özellikleri paralelinde tek kat ipliklerden ekstra fiziksel özellikler istenmektedir. Bunun bir sonucu olarak katlama ve büküm prosesleri, iplikteki fiziksel özellikleri geliştirmek amacı ile başvurulan bir yöntem haline gelmiştir. Günümüzde en fazla kullanılan büküm yöntemi two-for-one büküm yöntemidir. Her ne kadar çok az bilinse de Hamel büküm (elasto-twist) yöntemi de uygulanmakta olan bir diğer yöntemdir. Bu çalışmada Hamel büküm sisteminde beş farklı büküm değerinde Ne 70/2 iplik üretilmiştir. Üretilen iplik numunelerinin Uster, CV, kalın yer, ince yer, neps, mukavemet ve tüylülük değerleri tespit edilmiş ve elde edilen veriler değerlendirilmiştir. Elde edilen bulgular, büküm etkisi altında incelenen kalite parametrelerinde tüm numune grupları üzerinde iyileşme olduğunu ve bu sistemde de büküm seviyesinin kalite parametreleri üzerinde anlamlı bir etkisinin olduğunu göstermiştir.
Effect of organic load regulation on anaerobic digestion performance and microbial community of solar-assisted system of food waste
Authors: Zhen Xiaofei , Luo Miao , Dong Haiying , Fang Lei , Wang Weiwei , Feng Lei , Yu Qin
Published: March 2022

The semi-continuous digestion experiment of food waste was carried out based on a solar-assisted heat anaerobic digestion reactor. The effects of organic load regulation (OLR of 2.0, 4.0, 6.0 and 7.0 kg m−3 d−1 VS (volatile solid)) on methane production, physical and chemical parameters, and microbial community structure were studied. The results showed that 6.0 kg m−3 d−1 VS could achieve the optimal methane production as the anaerobic digestion limit OLR of kitchen waste. At this stage, the accumulation of organic acids in the reactor led to a great fluctuation of pH. Artificial alkali regulation could restore the stable operation of the reactor, but the reactor could not withstand the OLR shock of 7.0 kg m−3 d−1 VS. In addition, Qualcomm sequencing results showed that microorganisms showed high functional concentration and poor community richness under low OLR, and increasing OLR could promote microbial richness. At the same time, the Methanosaeta of acetic acid methanogens was relatively abundant in the low OLR stage, while the hydrogen trophic methanogenic bacteria Methanoregula and Methanospirillum showed high activity in the high OLR stage, but the excessive reproduction of acidogenic bacteria in the digestive system would affect the stability of the archaea community when the OLR was too high.
Grupo TA.LI.UM. -Textos selectos-
Authors: Aguirre Alarcón Adailton Manuel , Prado Morales Alberto , Escorcia Valencia Antonio , Múnera Benítez Camilo Andrés , Patiño Hernández Carlos Andrés , Romero Segrera Carmen Lorena , Manjarrez Herrera Cristian Camilo , Martínez Martínez David Orlando , Palacio Palacio Daylin Patricia , Carmona Arrieta Deiner Javier , Rebolledo Didier Lanao , Soledad Sáchez Diego Armando , Barros Pinto Eduardo , Carillo Ruiz Edwin Galeth , Arévalo Fontalvo Glenys Giomar , Lodoño Amarís Isabel Cristina , Sánchez Mendoza Jeannie Carolina , De la Cruz Valiente Joel , Guerra Osuna José Antonio , García Sarria Leydy Manuela , Herrera Villalobos Leidy Carolina , Acosta Acosta Martiniano , Avendaño Herrera Nelson Daniel , Lobo Urango Sara Sofía , Moreno Santiago Sergio Andrés , Mejía Rendón Yahel Tatiana , Meza Altamar Yarluis , Lapeira Escobar Yelena Isabel , Reyes Muñoz Yoleira Victoria
Published: March 2022

Cuando la desaparición del libro físico sea inminente, las reliquias en los museos sean devoradas por el fuego censor y de la arqueología de la lectura no quede nada, yo atesoraré aún más esta “saga” de antologías del Grupo Ta.li.U.M., no por mi nombre como editor, sino porque el genio de la literatura le permitió a cada autor cuestionamientos y transformaciones de algunas realidades en ficción, desde ese ilusorio universo en sus mentes, con versos o tramas, para enfrentarse a un tiempo de injusticias, muerte y desinformación. Los doce trabajos poéticos dan cuenta de introspecciones recreadas en múltiples ámbitos de la cotidianidad; los veinte narrativos apuntan a secuencias que transitan las fronteras de lo onírico en personajes que encontraron su voz, y la novedad de cinco trabajos académicos para invitar a talleristas y lectores a trascender la creación artística hacia la escritura de ensayos tan necesarios para la literatura local. En definitiva, 30 protagonistas, entre ellos 17 estudiantes y 11 graduados, entre dos docentes y mi persona. Si este libro llegó a tus manos, atesóralo como el último, léelo, sácate una selfie y compártela en tus estados, porque ya no volverás a ser el mismo.
Dynamics of Spatial Inequality in the Development of us Healthcare and State Regional Policy
Authors: Minat V. N.
Published: March 2022

One of the key aspects that reveals the essence of the uneven distribution of social benefits in economically developed countries is the dynamics of spatial inequality that has been characteristic of the US healthcare sector for many decades. The results of an empirical study of this inequality as a dynamic process with the properties of historicism, carried out by decomposition of the Theil index according to the intragroup and intergroup characteristics of the corresponding groups of indicators, indicate an increase in the polarization of territories in terms of the provision of the population with medical benefits. Given the organizational and economic inconsistency in the health care of American citizens and the predominance of the spontaneous and commercial nature of free pricing in the relevant markets of American medical goods and services, the center-peripheral spatial structure of inequality in the development of US health care, traditional for capitalist reproduction, is confirmed.

The objective nature of the long-term formation of such a structure is complemented by the subjective factor of state regional regulation of health care in the subregional and transregional sections, through the implementation of differently directed typologically relevant policies – from traditional and proactive to selective. It is shown that not only the economic situation, but also the socio-political and ideological expediency are the subjects that determine the tools for activating, polarizing, stimulating or restraining the development of healthcare in specific areas of the United States.
Marine Polysaccharides in Tailor-made Drug Delivery
Authors: Manna Sreejan , Jana Sougata
Published: March 2022

Marine sources have attracted much interest as an emerging source of biomaterials in drug delivery
applications. Amongst all other marine biopolymers, polysaccharides have been the most investigated class of
biomaterials. The low cytotoxic behavior, combined with the newly explored health benefits of marine polysaccharides,
has made it one of the prime research areas in the pharmaceutical and biomedical fields. This review
focused on all available marine polysaccharides, including their classification based on biological sources. The
applications of several marine polysaccharides in recent years for tissue-specific novel drug delivery, including
gastrointestinal, brain tissue, transdermal, ocular, liver, and lung, have also been discussed here. The abundant
availability in nature, cost-effective extraction, and purification process, along with a favorable biodegradable
profile, will encourage researchers to continue investigating marine polysaccharides to explore newer applications
targeting the specific delivery of therapeutics.
Recent Advances in Pinacol Rearrangement
Authors: Jin Ye , Liu Mao , Cong Hang , Ge Qingmei
Published: March 2022

A pinacol rearrangement is a well-known reaction by which a 1,2-diol is converted
to a carbonyl compound through acid-catalyzed dehydration followed by a 1,2-migration of
one of the neighboring substituents. Due to the particular abilities in installing polycyclic skeletons,
quaternary carbon centers, and spirocyclic cores, the pinacol rearrangement reaction is a
powerful and effective means of forming carbonyl functional groups in a variety of different
molecules. Moreover, the substrates with an alkene group, a furan ring or alkyl chain tethered
between the two diols have also been investigated as the expansion of pinacol rearrangement.
Benefiting from the continuous development of the catalysis methodologies, pinacol rearrangements
demonstrate synthetic utility in the preparation of natural products, bioactive molecules,
and other functionally useful compounds. In this review, we discuss recent advances in
the development of pinacol rearrangement and extended pinacol rearrangement reactions catalyzed by Brønsted
acid, Lewis acid, and heterogeneous catalysts. In addition, we summarize several examples use pinacol rearrangements
used in the synthesis of natural products and other valuable molecules.
Mechanism Research of Platelet Core Marker Prediction and Molecular
Recognition in Cardiovascular Events
Authors: Qin Dui , Li Zhangyong , Wang Hongdan , Zhang Bingyu , Zhong Xianhua
Published: March 2022

Background:

Thrombosis triggered by platelet activation plays a vital role in the pathogenesis
of cardiovascular and cerebrovascular diseases.

Objective:

This study aims to find platelet combined biomarkers for cardiovascular diseases and
investigate the possibility of Concanavalin A (ConA) acting on platelets as a new pharmacological
target.

Methods:

High-throughput Technology and bioinformatics analysis were combined and groups of
microarray chip gene expression profiles for acute myocardial infarction (AMI) and sickle cell disease
(SCD) were obtained using GEO database screening. R language limma package was used to
obtain differentially expressed genes (DEGs). GO, KEGG, and other databases were utilized to
perform the enrichment analysis of DEGs’ functions, pathways, etc. PPI network was constructed
using STRING database and Cytoscape software, and MCC algorithm was used to obtain the 200
core genes of the two groups of DEGs. Core targets were confirmed by constructing an intersection
area screening. A type of molecular probe, ConA, was molecularly docked with the above core targets
on the Zdock, HEX, and 3D-DOCK servers.

Result:

We found six core markers, CD34, SOCS2, ABL1, MTOR, VEGFA, and SMURF1,
which were simultaneously related to both diseases, and the docking effect showed that VEGFA is
the best-performing.

Conclusion:

VEGFA is most likely to reduce its expression by binding to ConA, which could affect
the downstream regulation of the PI3K/Akt signaling pathway during platelet activation. Some
other core targets also have the opportunity to interact with ConA to affect platelet-activated
thrombosis and trigger changes in cardiovascular events.
A Review of Biological Applications of Transition Metal Complexes Incorporating
N-acylhydrazones
Authors: Hamzi Imane
Published: March 2022

In view of the crucial importance of the bioactivities of N-acylhydrazone derivatives and
their corresponding metal complexes, N-acylhydrazones have recently attracted the attention of researchers
in the chemical, biological, and pharmaceutical fields. This review aims to describe Nacylhydrazone
complexes involving transition metal ions, such as copper, chromium, manganese,
iron, cobalt, nickel, and zinc, and investigate their properties and possible applications in various domains.
The most promising applications of the number of transition metal complexes incorporating Nacylhydrazones
in biology, medicine, and pharmacology are also examined and determined.