bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Analysis of User Satisfaction Levels on Livin By Mandiri and BSI Mobile Applications Using the PIECES Method
Authors: Ayu Sahira Putri
Published: February 2024

In social life, transactions are inseparable from humans. In general, exchange activities, means of payment for goods, are gradually being replaced in the modern world with the presence of banks to facilitate all human transactions. The facilities provided by banks centrally are Mobile Banking (M-Banking) or banking services through digital or mobile phones that function almost like ATMs. Livin By Mandiri and BSI Mobile are among the mobile banking providers with around 62 million users. As a new thing that has just entered the country, mobile banking, especially applications launched for the needs of the community, requires satisfaction analysis. Aiming at these issues, this study examines the effectiveness and efficiency of the system from the following aspects: User interface convenience. The following research aims to analyze user satisfaction of Livin By Mandiri and BSI Mobile mobile banking applications. User satisfaction analysis is determined using qualitative research methods and PIECES or performance, information and data, economy, control and safety, efficiency, service methods. The results showed that both applications had good performance according to PIECES indicators, but in terms of information, BSI Mobile outperformed Livin By Mandiri in the category and the Livin By Mandiri application outperformed BSI Mobile in terms of efficiency. With these satisfactory results, Livin By Mandiri and BSI Mobile can be said to be very good and this value must be maintained.
Plan de negocios para alojamiento y cuidado para tu mascota “Aloha Patitas” en Lima metropolitana
Authors:   , Allasi Villanueva Jose Luis , Latorre Vera Jorge Napoleon , Pastorelli Huanes Luis Alberto , Porles Diaz Mirko Freddy , Roldan Villafuerte Renato Rai
Published: February 2024

En “ALOHA PATITAS”, centro de alojamiento y cuidado de tu mascota, ofrecemos un lugar alejado, seguro y cómodo dedicado para la diversión y cuidado, sea cual fuera tu mascota. Hemos desarrollado un ambiente único dedicado al entretenimiento, cuidado, adiestramiento y salud de todo tipo de mascota para esos momentos en que el tiempo no te permita compartir con ellos. Nuestro ambiente cuenta con amplias instalaciones de diversión siempre acompañados con personal especializado en comportamiento animal de cualquier especie. A través de nuestro equipo de profesionales totalmente comprometidos con la felicidad y cuidado de tu mascota, les brindamos calidad de tiempo, alimentación, asistencia médica, así como monitoreo de su salud. Por medio de nuestro aplicativo “ALOPAT” te damos acceso a compartir a distancia en tiempo real la estadía de tu mascota y puedas seguir sus diversas actividades del día, así como consultas y recomendaciones a los especialistas “on line” dándote de esta manera la seguridad y tranquilidad que ellos se encuentran disfrutando en manos de excelentes profesionales y amigos de los animales.
Nueva vivienda social para lograr adecuadas condiciones de habitabilidad en el Centro Histórico de Lima, 2021
Authors:   , Chavez Castro Sibyla Benedicta , Corilla Almonacid Karen Miscella
Published: February 2024

La presente tesis tiene como objetivo determinar los criterios y lineamientos para diseñar viviendas sociales flexibles en un entorno con contexto histórico y monumental, donde se busca relacionar la arquitectura y urbanismo con la memoria cultural del lugar. Así mismo, con la propuesta pretendemos brindar adecuadas condiciones de habitabilidad en el Centro Histórico de Lima, 2021. Ello permite brindar viviendas de calidad a familias de bajos recursos otorgándoles confort, seguridad, flexibilidad y habitabilidad. La investigación tiene un enfoque mixto; es decir, cualitativo y cuantitativo, y se desarrolló por fases. La primera fase consistió en la revisión bibliográfica de los principales temas: viviendas flexibles, habitabilidad y vivienda social. La segunda fase fue la construcción del estado de la cuestión de los referentes teóricos de la flexibilidad y habitabilidad. La tercera fue la determinación de la variable y desglose de las dimensiones e indicadores. La cuarta fase fue el análisis de referente construidos. La quinta fase fue el registro de las necesidades de los habitantes a través de una encuesta, y finalmente la última fase fue determinar los resultados, conclusiones y recomendaciones, para el diseño del proyecto de vivienda social. De acuerdo con el análisis de la habitabilidad de la nueva vivienda social, según las dimensiones e indicadores determinados, se extraen los principales resultados: i. En la flexibilidad habitacional se determinó que necesario brindar espacios multifuncionales, mediante muebles adaptable, paneles móviles internos y externos con la finalidad de cubrir la necesidad actual de las familias ii. En la seguridad residencial se resolvió que es fundamental brindarle a la vivienda privacidad con el espacio público iii. En las necesidades psicosociales se precisó brindar espacios urbanos adecuados que faciliten las relaciones sociales de los habitantes. A partir de estos resultados se identificaron las estrategias para el diseño de la vivienda social en Centro Histórico de Lima, que fueron utilizados para la propuesta en el diseño arquitectónico.
Gestión por procesos y rentabilidad de una empresa comercializadora de productos veterinarios, distrito de Los Olivos (Lima-Perú), 2021
Authors:   , Leguia Lizana Jhonatan Jesus
Published: February 2024

El trabajo de investigación tuvo por título Gestión por procesos y rentabilidad de una empresa comercializadora de productos veterinarios, distrito de Los Olivos (Lima-Perú), 2021 y el objetivo general fue determinar la relación entre la gestión por procesos y la rentabilidad de dicha empresa. Sobre la metodología, fue desarrollada con un enfoque cuantitativo, bajo un diseño de investigación no experimental, transeccional, de alcance correlacional, donde la población al igual que la muestra se vio representada por 24 trabajadores de la empresa en los distintos cargos y funciones que se desempeñan en la cotidianidad. La técnica empleada para obtener los datos consistió en la aplicación de una encuesta utilizando un cuestionario basado en una escala tipo Likert, este cuestionario fue diseñado por el investigador y validado por expertos. Posteriormente, los datos obtenidos fueron sometidos a un análisis estadístico mediante el uso del programa IBM SPSS Statistics versión 26. Los resultados del análisis mostraron que el coeficiente alfa de Cronbach para la variable gestión por procesos fue de 0.787, mientras que para la variable rentabilidad fue de 0.748. Asimismo, al realizar las pruebas de hipótesis mediante la correlación de Pearson, se obtuvo un valor de significancia de 0.645, el cual resultó mayor que 0.05. En consecuencia, la conclusión obtenida en relación con el objetivo planteado es que no se encontró una relación directa ni significativa entre la gestión por procesos y la rentabilidad en una empresa comercializadora de productos veterinarios ubicada en el distrito de Los Olivos (Lima-Perú), durante el 2021.
¿Cuáles son los factores socioeconómicos que ayudan a predecir la asistencia juvenil a conciertos masivos de música en vivo durante el período post COVID en el Perú? Evidencia de una muestra de estudiantes universitarios
Authors:   , Anaya Marcelo Yely Carmen
Published: February 2024

El objetivo de esta investigación es determinar los factores socioeconómicos que ayudan a predecir la asistencia juvenil a conciertos masivos de música en vivo durante el período post COVID en el Perú. Para ello, se analiza la “Encuesta sobre consumo de música” aplicada por el Grupo de Investigación Economía y Finanzas de la Universidad Científica del Sur, la cual recopila la información de 269 estudiantes y egresados universitarios de la carrera de Ingeniería Económica y de Negocios de dicha casa universitaria. El análisis empírico se basa en la estimación de un modelo de regresión binario a través de la metodología de máxima verosimilitud. Los resultados muestran que la asistencia a conciertos tiene un comportamiento persistente pues haber asistido a un concierto masivo antes de la pandemia aumenta la probabilidad de asistir a uno luego de la pandemia. Además, la probabilidad de asistir a un concierto masivo depende de la situación laboral, del medio de consumo de música, de la edad y del lugar de residencia.
Gestión administrativa y eficiencia en la contratación de bienes y servicios menores a 9 UIT en el personal administrativo de una Municipalidad distrital en Lima Sur (Perú), 2022
Authors:   , Cabrera Garcia Gonzalo
Published: February 2024

La contratación pública supone un mecanismo mediante el cual el Estado contrata con proveedores a fin de obtener bienes y servicios para así poder brindar una adecuada atención a la población. Por ello, este estudio tomó como propósito analizar en qué medida la gestión administrativa se relaciona con la eficiencia en el proceso de adquisición de bienes y servicios menores a 9 UIT en el personal administrativo de una municipalidad distrital en Lima Sur (Perú). El estudio tuvo un enfoque cuantitativo, de tipo correlacional. Para la recolección de datos se utilizó la técnica de la encuesta, siendo aplicada a una muestra de 50 trabajadores administrativos de una comuna distrital. Los resultados obtenidos permitieron evidenciar falencias administrativas que afectan de manera negativa los procesos administrativos relacionado a las contrataciones públicas. De este modo, a medida que haya mejoras en la gestión administrativa, repercutirá favorablemente en la eficiencia del personal administrativo de una municipalidad.
Quantitative Prediction of the Development and Opening Sequence of Fractures in an Ultradeep Carbonate Reservoir: A Case Study of the Middle Ordovician in the Shunnan Area, Tarim Basin, China
Authors: Li Yuntao , Ding Wenlong , Han Jun , Chen Xuyun , Huang Cheng , Li Jingtian , Ding Shihao
Published: February 2024

Quantitative prediction of reservoir tectonic fracture development characteristics, opening pressures, and opening sequences is critical in the exploration and development of oil- and gas-bearing reservoirs and thus has received widespread attention. Using numerical simulations of the paleostress field during the formation of tectonic fractures and the rock fracture criterion, we predict the development and occurrence of fractures in the Middle Ordovician Yijianfang Formation in the Shunnan region of the Tarim Basin, China. The local paleostress fields reflected by the mechanical properties and occurrence of tectonic fractures obtained from core descriptions, acoustic emission (AE) experiments, paleomagnetic experiments, sound velocity measurements, and borehole breakouts were used to determine the regional paleostress and in-situ stress. We established a geomechanical model by combining the mechanical parameters of the rocks with the finite element method (FEM), optimizing the boundary conditions with a self-adaptive constraint algorithm, and conducting numerical simulations of the in-situ stresses. Fracture occurrence and numerical simulation results of the in-situ stress field were used to determine the opening pressure (Pk) and opening sequence of the fractures. The level of fracture development decreases away from the strike-slip fault in the study area. Fracture development is positively correlated with the Young’s modulus, paleostress difference, and paleostress difference coefficient of the rock. The direction of the maximum horizontal principal stress is from north-northeast (NNE) to northeast (NE). Initially, shear fractures and tensional fractures oriented NNE 30°–35° and NE 40°–45°, respectively, open during the water injection process. Pk is positively correlated with the horizontal stress difference coefficient and the angle between the fracture strike and the maximum horizontal principal stress. At the structural highs (burial depths shallower than 6450 m) and the structural lows (burial depths deeper than 6450 m), the burial depth correlates negatively and positively with Pk, respectively. This investigation of the development, occurrence, Pk, and opening sequence of tectonic fractures and their principal controlling factors will have a positive impact on the future exploration and production opportunities of similar fractured reservoirs.
Assessment of the magnitude and associated factor of psoriasis at Saint Paul’s Hospital Millennium Medical College among patients attending Dermatology clinic, Addis Ababa, Ethiopia.
Authors: Abza Fantahun , Demisse Tsion , Muhammad Feysel
Published: February 2024

Background
Psoriasis is a chronic, inflammatory skin disorder resulting from a genetic predisposition combined with environmental triggers characterized by sharply demarcated erythematosus whitish scaly plaques. May be associated with psoriatic arthritis, metabolic syndrome, and other diseases. The prevalence is about 2% of the world’s population. Two peaks in the age of onset have been reported: Early-onset psoriasis at 20–30 years of age and Late-onset psoriasis at 50–60 years of age & equal in both sexes.
Objectives
This study aimed to assess the magnitude and associated factors of psoriasis from October 2021 to June 2022 at Saint Paul’s Hospital Millennium Medical College Addis Ababa.
Methods
A hospital-based cross-sectional prospective study was conducted from October 2021 to June 2022. A total sample size of 422 patients aged from 11 and above years was included in the study. Then using SPSS version 21.0 The data was entered and analyzed. Descriptive analysis was done to characterize the study participants. Bivariate and multivariable logistic regression was performed to determine the crude and independent predictors of the dependent variable. AOR with 95% CI was used to determine the independent predictors of psoriasis. Statistically, a significant association was considered at a p-value < 0.05.
Result
In this study, the magnitude of psoriasis was found to be 6.01% (95% CI:11.6,18.7). Moreover, in the multivariable logistic regression model educational status AOR (95% CI): =0.054, (0.01–0.30). And patients themselves AOR (95%CI): =34.90, (8.27–147.30) stress history were significant predictors of psoriasis.
Conclusion
In this study 6.01% of patients were found to have psoriasis disease. Therefore, the finding needs to give great attention to strengthening national skin disease prevention and control services and implementation of public health policies on awareness, prevention, and treatment of psoriasis patients to keep care of skin and not neglect the disease contact health facility services.
Groundwater used for human consumption causes histological and molecular changes in the thyroid that affect the morphogenesis process of xenopus laevis
Authors: Modarelli Maria Fernanda , Bilbao Rodrigo Miguel , Ponzo Osvaldo Juan
Published: February 2024

Groundwater is a reservoir of fresh water. In the goitrous areas the water used for drinking and cooking generally is high in nitrate content. The aim of the present study was to evaluate in that areas, chronic effects to expose of xenopus laevis larvae during a complete metamorphosis process to groundwater. For analyze the effects on thyroid function. The xenopus laevis larvae were divided into 3 work groups submerged, until the end of metamorphosis, in: drinking water as control (C), groundwater as group (G) and drinking water plus potassium perchlorate as positive control (PC). In (G) group metamorphosis process was completed in 37% and 0% in (PC) (p < 0.0001). In the 60 of Niewkoop and Faber, stage the wet weight and body length was in (G) smaller than (C) and (PC) (p < 0.0001). But was not difference in 62 for (G), (PC) was bigger than (C). In 60 stage was no significant differences on the length of the hind limbs. In 62 was bigger in (G) and (PC) than in (C) (p < 0.001). Thyroid hyperplasia was grade 2 in (G) and 3 (PC) (p < 0.001) in 60 stage and 3 in (G) and (PC) in the 62 (p < 0.0001). Follicular hypertrophy and colloid depletion in (G) and (PC) (p < 0.0001). In groundwater was found high nitrates concentrations. These findings suggest that nitrate contaminate groundwater impairs thyroid function of xenopus laevis larvae. These observation could contribute to the current discussion about the acceptable daily intake of nitrate.
Analysis of quantitative OCT and SS-OCTA metrics three months after initiation of intravitreal faricimab for treatment-recalcitrant neovascular AMD
Authors: Mirza Rukhsana , Nadel Arnold , Drakopoulos Michael , Bains Harnaina , Bar-Meir Avram , Marchese Alessandro , Lyon Alice
Published: February 2024

Purpose
To utilize optical coherence tomography (OCT) and SS-OCT angiography (SS-OCTA) for quantifying morphological changes seen in eyes with recalcitrant neovascular age-related macular degeneration (nAMD) transitioned to intravitreal faricimab injections during the manufacturer’s recommended induction phase of treatment.
Methods
Fifty-four treatment-recalcitrant patients (60 eyes) were recruited. OCT and SS-OCTA images were obtained at 0 and 3 months. Best corrected visual acuity (BCVA), OCT, pigment epithelial detachment (PED), and macular neovascularization (MNV) parameters were analyzed at baseline and 3 months.
Results
Thirty-two patients (38 eyes) were included in baseline OCT characteristic analysis, 29 patients (35 eyes) in MNV analysis, and 18 patients (21 eyes) in PED analysis. Significant decreases in PED parameters were observed, including PED volume (mean = -19.66%, 95% CI [-36.77, -2.40], p = 0.0114), mean height (mean = -19.16%, 95% CI [-33.50, -4.81], p = 0.0114), and maximum height (mean = -15.28%, 95% CI [-25.59, -4.97], p = 0.0057). Significant decreases in MNV metrics were also observed, including area (mean = -9.06%, 95% CI [-15.45, -2.66], p = 0.0069) and vessel density (mean = -8.23%, 95% CI [-12.46, -4.01], p = 0.0004). BCVA remained stable between baseline and 3 months.
Conclusions
In recalcitrant nAMD patients who were transitioned to faricimab, patients maintained their vision while significant improvements in OCT PED and SS-OCTA MNV parameters were seen during the induction phase.
4.8-μm CO-filled hollow-core silica fibre laser
Authors: wang zefeng , Li Xuanxi , Yang Linyong , Zhou Zhiyue , Li Zhixian , Li Hao , Pei Wenxi , Huang Wei , Shi Jing , Lei Luohao , Wang Meng
Published: February 2024

Mid-infrared (MIR) fibre lasers are important for a wide range of applications in sensing, spectroscopy, imaging, defense, and security. Some progress has been made in the research of MIR fibre lasers based on soft glass fibres, however, the emission range of rare-earth ions and the robustness of the host materials are still a major challenge for MIR fibre lasers. The large number of gases provide a variety of optical transitions in the MIR band. When combined with recent advances in low-loss hollow-core fibre (HCF), there is a great opportunity for gas-filled fibre lasers to further extend the radiation to the MIR region. Here, a 4.8-µm CO-filled silica-based HCF laser is reported for the first time. This is enabled by a homemade broadband low-loss HCF with a measured loss of 1.81 dB/m at 4.8 µm. A maximum MIR output power of 46 mW and a tuning range of 180 nm (from 4644 to 4824 nm) are obtained by using an advanced 2.33-µm narrow-linewidth fibre laser. This demonstration represents the longest-wavelength silica-based fibre laser to date, while the absorption loss of bulk silica at 4824 nm is up to 13, 000 dB/m. Further wavelength expansion could be achieved simply by changing the pump absorption line. This work paves the way for the MIR silica fibre laser beyond 5 µm.
Process optimization-oriented deformation control of large aluminum alloy structures from high-speed EMU
Authors: Li Yana , Liu Jiahao , Zhang Zeyang , Dai Changlun , Yin Xingfu , Shi Xinpeng
Published: February 2024

Predicting and controlling the welding deformation of large aluminum alloy structures is crucial to ensure the accuracy during the manufacturing of high-speed electric multiple units (EMUs). On the basis of heat source calibration, the dual ellipsoid heat source model and simplified equation parameters were used for metal-inert gas (MIG) welding, and the simulation of residual stresses obtained from the three numerical simulation methods were compared with the experimental values, and it was determined that the thermoelastic-plasticity method was used as a method to establish a high-precision inherent strain database. Based on this database, the welding deformation of the entire sidewall (23 m, 44 welds) was predicted and compared with the experimental data, and the error of the two results was less than 1 mm, and the simulation model was able to reflect the actual situation. Meanwhile, on the basis of this model, the effects of welding sequence, spot fixing method and number of clamps on welding deformation were investigated separately, and the results showed that: the reasonable welding sequence reduced the maximum deformation by 30.90%; the appropriate spot fixing method reduced the maximum deformation by 12.56%; and the reduction of the number of clamps by 9% could get the same effect as the original scheme, and the reduction of the number of fixtures by 18% could still ensure that the overall deformation was basically unchanged. Thus, process optimization can effectively control welding deformation, providing insights for improving the welding quality of aluminum alloy-based high-speed EMUs structures.
Baseline knowledge on risk factors, symptoms and intended behaviour of women and men towards screening and treatment of cervical cancer in rural Uganda: A cross-sectional study
Authors: Nakisige Carolyn , Fouw Marlieke , Nakalembe Miriam , Jackson Orem , Atukonyera Dan , Musheshe Mwalimu , Koot Jaap , Zeeuw Janine , Beltman Jogchum , Stekelenburg Jelle
Published: February 2024

Background
Knowledge of risk factors and symptoms of cervical cancer has been found to promote uptake of screening of cervical cancer. Most interventions targeted women without much involvement of men (husbands) who are often decision makers in many low- and middle-income countries. This study aimed at assessing baseline knowledge and intended behaviour of both women and men to enable design specific targeted messages to increase uptake of cervical cancer screening and promote early detection of women with symptoms.
Methods
This cross-sectional study was conducted in two districts in Western Uganda using the modified African Women Awareness of CANcer (AWACAN) questionnaire. Women aged 30–49 years and their husbands/decision makers were interviewed. Knowledge on risk factors and symptoms, intended behaviour and barriers towards participation in cervical cancer screening and treatment were assessed. Descriptive and logistic regression analyses were done to establish the association between knowledge levels and other factors comparing women to men.
Results
A total of 724 women and 692 men were enrolled. Of these, 71.0% women and 67.2% men had ever heard of cervical cancer and 8.8% women had ever been screened. Knowledge of risk factors and symptoms of cervical cancer was high and similar for both women and men.
Lack of decision making by women was associated with low knowledge of risk factors (X2 = 14.542; p = 0.01), low education (X2 = 36.05, p < 0.01) and older age (x2 = 17.33, p < 0.01). Men had better help seeking behaviour than women (X2 = 64.96, p < 0.01, OR = 0.39, 95% CI: 0.31 - 0.50) and were more confident and skilled in recognising a sign or symptom of cervical cancer (X2 = 27.28, p < 0.01, OR = 0.52, CI (0.40 - 0.67).
Conclusion
The baseline knowledge for cervical cancer was high in majority of participants and similar in both women and men. Their intended behaviour towards screening was also positive but screening uptake was very low. This study suggests developing messages on multiple interventions to promote screening behaviour in addition to education, consisting of male involvement, women empowerment and making services available, accessible and women friendly.
Mindfulness associated with less Fear of Missing Out: Social Media Addiction as a mediator
Authors: Aldbyani Aamer
Published: February 2024

This cross-sectional study aimed to investigate the relationship between mindfulness, fear of missing out and social media addiction. and the potential mediating role of social media addiction in the association of mindfulness with Fear of Missing Out. Four hundred and seventy-six international students in China were recruited to complete the Mindful Attention Awareness Scale (MAAS), the Fear of Missing Out Scale (FOMOS), and the Bergen Social Media Addiction Scale (BSMAS). The results found that mindfulness correlated negatively with social media addiction and fear of missing out. Furthermore, social media addiction was positively correlated with fear of missing out. Structural equation modelling revealed that the mediation model fit the data well, That’s is, social media addiction partly mediated the association of mindfulness with Fear of Missing Out. We concluded that this insight contributes to a better understanding of the interplay between mindfulness, social media use, and the psychological aspects of fear of missing out, providing valuable implications for interventions and strategies to promote healthier online behaviours and mental well-being among the target population.
Penetration resistance of joint joints of constrained ceramic-metal composite structures
Authors: Wu Hao
Published: February 2024

Aiming at the problems of edge weakening effect and gap defects in ceramic metal composite structure, the anti-penetration performance of ceramic metal composite structure was studied. Based on the experimental study of ceramic metal composite structure against 7.62 mm armor-piercing incendiary projectile penetration, the numerical model of ceramic metal composite structure against penetration was established. According to the experimental results, the reliability of the numerical simulation method was verified, and the anti-penetration performance at the ceramic joint was analyzed. The results show that the aluminum alloy sandwich plate can provide effective support for the ceramic. With the increase of the thickness of the aluminum alloy sandwich plate, the anti-penetration performance of the composite structure is improved. The anti-penetration performance of the composite structure increases with the increase of the thickness of the UHMWPE backplane. When the backplane reaches a certain thickness threshold, increasing the thickness of the backplane cannot significantly improve the anti-penetration performance of the composite structure. Adding a certain thickness of metal separator at the joint can effectively reduce the damage of ceramics.
The structural basis of DSAD1-DSR2 mediated phage immune evasion
Authors: Li Faxiang , Wang Ruiwen , Xu Qi , Wu Zhuoxi , Li Jialu , Guo Hao , Liao Tianzhui , Shi Yuan , Yuan Ling , Gao Haishan , Yang Rong , Shi Zhubing
Published: February 2024

DSR2 belongs to the family of defense-associated sirtuins (DSRs) which protect bacteria from phage infection by hydrolyzing NAD+. Phage propagation is effectively inhibited through the induction of abortive infection by depleting this essential molecule. The enzymatic activity of DSR2 is triggered by the tail tube protein of phages, enabling its functional activation. To escape bacterial immunity, certain phages have evolved to encode DSAD1 protein, which binds to and deactivates DSR2, neutralizing its defensive capabilities. However, the structural basis underlying the degradation of NAD+ by DSR2 and the inhibitory mechanism of its NADase activity by DSAD1 remain elusive. Here, we report the cryo-EM structures of apo DSR2 from Bacillus subtilis and the DSR2-DSAD1 complex. The apo structure reveals that DSR2 assembles into a head-to-head tetramer, which is mediated by its N-terminal Sir2 domain. DSR2 Sir2 domain possesses the highly conserved residues that have been found to be essential for NAD+ coordination and depletion in ThsA. The structures of DSR2-DSAD1 complex demonstrate the binding of two DSAD1 molecules to the two of four C-terminal helical regions of DSR2 tetramer, forming a hetero-hexameric complex. Two DSAD1 protomers locate separately at two ends of DSR2 tetramer either on the same side or opposite sides. This binding at DSR2 C-terminus induces a conformational change in the Sir2 domain at its N-terminus, potentially suppressing its enzymatic activity. These findings not only broaden our understanding of the DSR2-mediated anti-phage defense system, but also uncover the mechanism of DSAD1-dependent phage immune evasion.
Role of Reactive C protein in Mediating the Effect of body mass index on bladder cancer Diseases
Authors: Chen# Junhao , Zuo# Jieming , Shi# Hongjin , Li# Xiangyun , Zhan Peiqin , Wang Haifeng , Fu Shi
Published: February 2024

Purpose: To investigate whether C-reactive protein (CRP) can mediate the causal relationship between body mass index (BMI) and the development of bladder cancer (BC), further elucidate the underlying mechanisms and the mediating role of CRP, and quantify the proportion of CRP in this mechanism.
Methods: Using two-sample Mendelian randomization and multivariable Mendelian randomization studies, we explored whether CRP serves as a mediator in the causal relationship between BMI and BC, and calculated the proportion of mediation in this context.
Results: There is a positive causal relationship between BMI and BC (OR=1.655, 95% CI=1.122-2.441, p=0.011). BMI is positively causally related to CRP (OR=1.237, 95% CI=1.175-1.304, p=9.417×10-16). CRP is also positively causally related to BC (OR=1.401, 95% CI=1.017-1.929, p=0.038). After adjusting for CRP, there is no causal relationship between BMI and BC (OR=1.413, 95% CI=0.959-2.081, p=0.079). Even after controlling for BMI, there is still a causal relationship between CRP and BC (OR=1.434, 95% CI=1.042-1.973, p=0.026). The mediating effect of CRP is 15.9%.
Conclusion: Using genetic data, this study provides evidence that higher levels of C-reactive protein (CRP) may serve as a mediator in the pathway through which BMI leads to BC. Clinical practitioners should pay closer attention to the inflammatory marker CRP levels in obese individuals for better BC prevention strategies.
Effect of Yoga-based Exercise Program in Female Patients With Myofacial Pain of Temporomandi̇bular Di̇sorders
Authors: ATILGAN ESRA , Kurt Hanefi , Algun Zeliha Candan
Published: February 2024

Objectives: The study was conducted to investigate the effect of Yoga-based exercise program on pain, range of motion (ROM), quality of sleep, depression and quality of life in female patients with myofacial pain of temporomandibular disorders (TMD) .
Materials and Methods: 39 Female patients with myofacial pain of TMD were included in the study. Yoga based exercise program was performed to the first group and second group was control group. Visual Analog Scale (VAS), Neck Pain and Disability Scale (NPDS), neck and jaw ROM, Pittsburg Sleep Quality Index (PUQI), Beck Depression Inventory (BDI) and Short Form 36 (SF36) were evaluated. Evaluations were repeated before treatment and 6 weeks later.
Results: From the measurements, a decrease in chin (p=0.021) and neck pain (p=0.031) was found to be significant in favor of Yoga Group. It was observed that the increase in ROM in the neck right lateral flexion (p=0.045), left rotation (p=0.020) and chin left depression (p=0.034) was in favor of Yoga Group. The sleep quality did not change. In yoga group, a decrease in depression level(p=0,023) and increase Quality of life in parameters of physical function (p=0.023), vital capacity (p=0.026), emotional health (p=0.002), mental health (p=0.080) were found as significant, statistically.
Conclusions: It was concluded that yoga-based exercise program can be used as an alternative program in patients with myofacial pain of TMD. Further study on myofascial pain of TMD is recommended.
Clinical Relevance: Yoga-based exercise program can be used in patients with myofascial pain due to TMD.
The Gammaproteobacteria Epidemiologic Annotation Pipeline
Authors: Dickey Aaron M. , Schmidt John W. , Bono James L. , Guragain Manita
Published: February 2024

Salmonella enterica and Escherichia coli are major food-borne human pathogens, and their genomes are routinely sequenced for clinical surveillance. Computational pipelines designed for analyzing pathogen genomes should both utilize the most current information from annotation databases and increase the coverage of these databases over time. We report the development of the Gammaproteobacteria Epidemiologic Annotation (GEA) pipeline to analyze large batches of E. coli and S. enterica genomes. The GEA pipeline takes as input paired Illumina raw reads files which are then assembled followed by annotation. Alternatively, assemblies can be provided as input and directly annotated. The pipeline provides predictive genome annotations for E. coli and S. enterica with a focus on the Center for Genomic Epidemiology tools. Annotation results are provided as a tab delimited text file. The GEA pipeline is designed for large-scale E. coli and S. enterica genome assembly and characterization using the Center for Genomic Epidemiology command-line tools and high-performance computing. Large scale annotation is demonstrated by an analysis of more than 14,000 Salmonella genome assemblies. Testing the GEA pipeline on E. coli raw reads demonstrates reproducibility across multiple compute environments and computational usage is optimized on high performance computers.
Adolescent health-risk behaviours in Thailand: patterns from national cross-sectional school surveys conducted in 2008, 2015, and 2021
Authors: Pengpid Supa , Peltzer Karl
Published: February 2024

Background: This study looked at trends in a number of health-risky behaviours among teenagers in Thailand from three separate surveys.
Methods: Data from 12,183 teenagers (mean age: 13.9 years, SD=1.2; age range: 11–16 years) who took part in three cross-sectional national school surveys in Thailand in 2008, 2015, and 2021 were analyzed. A self-administered survey was used to evaluate thirty-three health risk behaviours. By using logistic regression analyses to treat the study year as a categorical variable and adjusting food insecurity and age, the significance of a linear trend was examined.
Results: We found a significant increase in the prevalence of overweight/obesity, inadequate fruit and inadequate vegetables intake, leisure-time sedentary behaviour, physical inactivity, parental tobacco use, physical injury, bullying victimisation, loneliness, not having close friends, sleep problems, ever sex, and suboptimal hand hygiene after toilet use, and a significant decrease in physically attacked. Among boys, a significant increase of inadequate tooth brushing, and suboptimal hand hygiene (not always using soap to wash hands), and a decrease in smoking quit attempts, participation in physical fights, and number of sexual partners, and among females, a decrease in non-condom use was found. Furthermore, among girls, a significant increase in the prevalence of current tobacco use (cigarettes and other), current alcohol use, lifetime drunkenness, trouble from alcohol use, lifetime drug use, suicidal ideation and plan was found.
Conclusion: Overall, from 2008 to 2021, there was a decrease in four health risk behaviours among boys and/or girls, while among boys there was an increase in fourteen health risk behaviours and among girls twenty health risk behaviours. In Thailand, school health programmes for teenagers are recommended.
Analysis of ergot alkaloid gene expression and ergine levels in different parts of Ipomoea asarifolia
Authors: Olaranont Yanisa , Stewart Alyssa B. , Songnuan Wisuwat , Traiperm Paweena
Published: February 2024

Ergot alkaloids are renowned for their pharmacological significance and were historically attributed to fungal symbioses with cereal crops and grasses. Recent research uncovered a symbiotic relationship between the fungus Periglandula ipomoea and Ipomoea asarifolia(Convolvulaceae), revealing a new source for ergot alkaloid synthesis. While past studies have emphasized the storage of both the fungus and alkaloids in leaves and seeds, recent work has found they also occur in other plant parts. This study aimed to (1) examine expression of the dmaW gene, which plays a crucial role in ergot alkaloid biosynthesis, and (2) quantify ergot alkaloid levels across various organs and growth stages of I. asarifolia. Our findings revealed the highest levels of dmaW gene expression in young seeds and young leaves, whereas the highest ergine concentrations were found in mature leaves followed by young leaves. In light of previous studies, we propose three hypotheses to reconcile these conflicting results: (1) the possibility of an inefficient ergot alkaloid biosynthesis pathway, (2) the potential for a complex pathway involving different biosynthesis genes, and (3) the existence of an ergot alkaloid translocation system within the plant. Furthermore, ergine and ergot alkaloid biosynthesis gene expression were detected in stems, roots, and flowers, indicating that ergot alkaloids are produced and accumulated in all studied parts of I. asarifolia, rather than being solely confined to the leaves and seeds, as previously reported.
Graphene-Induced Enhanced Supercapacitor Properties of V2O5-GNPs Nanocomposites for Energy Storage Devices
Authors: Oneeb Muhammad , Iqbal Javed , Mumtaz Asifa , Ullah Qudrat , Ibrar Saba , khan Ahmad H. , Noman M
Published: February 2024

Metal oxides due to high specific capacitances are worthy for electrode material, yielding high energy and power-delivering capacities. Among them, Vanadium pentoxide (V2O5) is a very novel and economical electrode material for supercapacitors using alkaline aqueous electrolytes. In this work, V2O5 and Graphene (GNPs) nanocomposites have been synthesized to improve the conductivity, electrode porosity, and electrode surface area of V2O5. V2O5 nanorods were fabricated using a simple and flexible Sol-gel method, whereas V2O5/Graphene (GNPs) nanocomposites were prepared using an ex-situ approach. Structural analysis of nanocomposites has been performed through XRD, SEM, EDX, EDS, and FTIR. V2O5 nanorods distributed on GNPs substrates showed excellent results as an electrode material. In particular, the nanocomposites (V2O5)0.50 (GNPs)0.50 maintained 96.3% of the initial capacitance over 1350 cycles. High specific capacitance (990 F/g at 5 mV/s from CV, 800 F/g at 2 A/g from GCD), and low ohmic resistance of 0.44 Ω were achieved in 2M NaOH electrolyte. Additionally, these nanocomposites have excellent energy density (27.7 W-hr Kg− 1) at a power density of (1800 W Kg− 1) using a potential window of (0-0.5) V, which is higher than the most previously reported work on V2O5 for supercapacitor.
Impact of prior SARS-CoV-2 infection on postoperative recovery in patients with hepatocellular carcinoma resection
Authors: Fang Dan , Gan Biling , Wu Lei , Guo Chulin , Chen Zhihong , Zhou Shunan , Wu Fan , Xu Lianqun , Chen Zhenrong , Shi Ning , Jin Hao-Sheng
Published: February 2024

BACKGROUND
The impact of prior SARS-CoV-2 infection on postoperative recovery of patients who underwent liver resection for hepatocellular carcinoma (HCC) remains uncertain given the lack of sufficient evidence.
AIM
To investigate the impact of prior SARS-CoV-2 infection on postoperative recovery of patients who underwent liver resection for hepatocellular carcinoma (HCC).
METHODS
Patients who were pathologically diagnosed with HCC and underwent elective partial hepatectomy in Guangdong Provincial People’s Hospital between January 2022 and April 2023 were enrolled in this retrospective cohort study. The patients were divided into two groups based on their history of SARS-CoV-2 infection. Rehabilitation parameters, including postoperative liver function, incidence of complications, and hospitalization expenses, were compared between the two groups. Propensity score matching (PSM) was performed to reduce confounding bias.
RESULTS
We included 172 patients (58 with and 114 without prior SARS-CoV-2 infection) who underwent liver resection for HCC. No significant differences in the rehabilitation parameters were observed between the two groups. After PSM, 58 patients were selected from each group to form the new comparative groups. Similar results were obtained within the population after PSM.
CONCLUSION
Prior SARS-CoV-2 infection does not appear to affect postoperative rehabilitation, including liver function, postoperative complications, or hospitalization expenses among patients with HCC after elective partial hepatectomy.
Variable parameter Uzawa method for solving the indefinite least squares problem
Authors: Meng Lingsheng , Xin Kailiang , Li Jun
Published: February 2024

In this paper, the variable parameter Uzawa method is presented to solve the indefinite least squares problem. The proposed iterative method is unconditionally convergent, and its iterative algorithm and parameter designing are simple and efficient. Numerical experiments show that the variable parameter Uzawa method is superior to the USSOR method \cite{17} and the splitting-based randomized iterative method \cite{21}.
Evaluation of atmospheric conditions at a quasi-national park adjacent to the downtown of a highly industrialized Japanese city
Authors: Abe Momoko , Oniwa Sho , Imazu Hayato , Tanaka Tetsuhiro , Aikawa Masahide
Published: February 2024

The atmospheric condition at the quasi-national park adjacent to the downtown of a highly industrialized city was evaluated based on three-site observations (quasi-national park, downtown, and suburbs). The concentrations of NOx, NO, NO2, O3, SO2, and NH3 were determined. The NOx and NO2 concentrations at the quasi-national park were lower and higher than those downtown and in the suburbs, respectively. The O3 concentration at the quasi-national park was higher than that downtown and equivalent to that in the suburbs, indicating that the impact of O3 air pollution on plants and the forest ecosystem is potentially more severe at the quasi-national park than downtown. Potential ozone (PO), defined as \(\text{P}\text{O}={\text{O}}_{3}+{\text{N}\text{O}}_{2}-0.1\times \text{N}\text{O}\text{x}\), showed no statistically significant difference (p<0.05) among the three sites, indicating that the nitric oxide titration operated and controlled the O3 concentration across the entire city. The definite difference in the level among the three sites in the SO2 concentration strongly implied the large contribution of sulfur supply from stationary emission sources and ships located along the shoreline. Fog events at the quasi-national park could be attributed to the determination of the NH3 concentration at the quasi-national park, i.e., the effective scavenging of NH3 from the ambient air by fog water.
Carbon–Nitrogen Transmutation in Polycyclic Arenol Skeletons to Access N-Heteroarenes
Authors: Wei Hao
Published: February 2024

Developing skeletal editing tools is not a trivial task, and realizing the corresponding single-atom transmutation in a ring system without altering the ring size is even more challenging. Here, we introduce a skeletal editing strategy that enables polycyclic arenols, a highly prevalent motif in bioactive molecules, to be readily converted into N-heteroarenes through carbon–nitrogen transmutation. The reaction features selective nitrogen insertion into the C–C bond of the arenol frameworks by azidative dearomatization and aryl migration, followed by ring opening and re-cyclization of N,O-hemiketal to achieve carbon-to-nitrogen transmutation in the aromatic framework of the arenol. Using widely available arenols as N-heteroarene precursors, this alternative approach allowed the streamlined assembly of complex polycyclic (hetero)aromatics with broad functional group tolerance. This study further highlights the potential for complex skeletal editing sequences through combinations with other single-atom skeletal editing methods, providing an alternative for the development of N-heteroarenes and demonstrating significant potential in materials chemistry.
Connect, Collaborate and Tailor: A model of community engagement through infographic design during the COVID-19 pandemic
Authors: Vernon-Wilson Elizabeth , Tetui Moses , DeMarco Mathew , Grindrod Kelly , Waite Nancy M.
Published: February 2024

Background
Across the globe, racial and ethnic minorities have been disproportionately affected by COVID-19 with increased risk of infection and burden from disease. Vaccine hesitancy has contributed to variation in vaccine uptake and compromised population-based vaccination programs in many countries. Connect, Collaborate and Tailor (CCT) is a Public Health Agency Canada funded project to connect public health and healthcare professionals with underserved communities in order to create culturally adapted communication about COVID-19 vaccines. This paper describes the process and outcomes of this community engagement model that identified information gaps and created tailored tools to address misinformation and improve vaccine acceptance.
Methods
Semi-structured interviews with CCT participants were undertaken to evaluate the effectiveness of CCT and explore CCT members’ experiences of collaboration. Thematic analysis was used to produce representative themes.
Results
Analysis of interviews (n = 14) revealed that shared purpose and urgency in responding to the COVID-19 pandemic motivated co-operation between stakeholders. Acknowledgement of past harm, present health, and impact of social inequities on public service access was an essential first step in establishing trust. Creating safe spaces for open dialogue led to successful, iterative cycles of consultation and feedback between team members; a process that not only helped create tailored communication tools but also deepened engagement and collaboration. Over time, the infographic material development was increasingly directed by community representatives’ commentary on their group’s real-time needs and communication preferences. This feedback noticeably guided the choice, style, and presentation of infographic content while also directing dissemination strategies and vaccine confidence building activities.
Conclusions
The CCT process to create COVID-19 vaccine communication materials led to evolving co-operation between groups who had not routinely worked together before and strong community engagement as a key driver of change. Ensuring a respectful environment for open dialogue and visibly using feedback to create information products provided a foundation for building relationships. Finally, our data indicate participants sought reinforcement of close cooperative ties and continued investment in shared responsibility for community partnership-based public health.