bluuebunny/crossref_metadata_2025 huggingface dataset:
MicroRNA-650 suppresses KLF12 expression to regulate growth and metastasis of human ovarian cancer cells
Authors: Lu Xiaoyan , Han Yun , Han Yuwen , Huang Menghui , You Jun , Liu Yinglei , Ding Yingying , Zheng Yanli
Published: October 2022

MicroRNA-650 (miR-650) has been shown to regulate the development of human cancers. The present study investigated the role of miR-650 in ovarian cancer by targeting Krüppel-like factor 12 (KLF12). The results showed a down-regulation of miR-650 in tissues and cell lines. Overexpression of miR-650 caused a substaining decrease in the viability of CAOV3 cells by promoting apoptotic cell death. In silico analysis and dual luciferase assay revealed KLF12 as a potential target of miR-650. Unlike miR-650, KLF12 showed a substantial up-regulation in ovarian cancer tissues and cell lines. However, miR-650 overexpression suppressed KLF12 expression posttranscriptionally. Intrestingly, KLF12 knockdown inhibited the viability of CAOV3 cells by promoting apoptotic cell death. However, the expression of KLF12 eliminated the tumor suppressing effects of miR-650 in CAOV3 cells. Additionally, KLF12 knockdown or miR-650 overexpression suppressed CAOV3 cell migration and invasion. However, KLF12 overexpression eliminated the inhibitory effects of miR-650 on the migration and invasion of CAOV3 cells. Taken together, these results suggest that miR-650/KLF12 axis regulates the viability, migration, and invasion of CAOV3 cells an0d may prove to be an important therapeutic taregt.
MicroRNA-15 suppresses viability, migration and invasion of the human MG-63 osteosarcoma cells via inhibition of cyclin dependent kinase 6 (CDK6)
Authors: Shen Zhao , Wang Chen , Liu Bin , Du Jieli , Li Zhiqiang , Zhao Jitang
Published: October 2022

MicroRNA-15a-3p (miR-15) acts as tumor-suppressor in different human cancers including osteosarcoma. Nonetheless, the molecular function of miR-15 in osteosarcoma via suppression of cyclin dependent kinase 6 (CDK6) is yet to be studied. The results showed significant downregulation of miR-15 in osteosarcoma tissues and cell lines. Overexpression of miR-15 inhibited the proliferation and colony formation of the MG-63 osteosarcoma cells via induction of apoptosis. Moreover, miR-15 inhibited the migration and invasion of MG-63 osteosarcoma cells. The tumor-suppressive functional role of miR-15 was shown to be exerted via suppression of CDK6. The expression of CDK6 was upregulated in osteosarcoma and its silencing could exert growth inhibitory effects on human osteosarcoma cells. However, overexpression of CDK6 could nullify the tumor-suppressive effects of miR-15 on the MG-63 osteosarcoma cells. Taken together, miR-15 negatively regulates growth, migration and invasion of osteosarcoma cells by targeting CDK6 at post-transcriptional level. These findings suggest the therapeutic potential of miR-15/CDK6 in human osteosarcoma.
Circ_FOXO3 regulates KLF6 through sponge adsorption of miR-122-5p to repress H2O2-induced HBVSMC proliferation, thus promoting IA development in vitro model
Authors: Yue Pei Dong , Lu Ya Nan , Zhang Lei , Ma Zheng Fei
Published: October 2022

Purpose: The phenotypic transformation of human brain vascular smooth muscle cells (HBVSMC) is widely involved in the appearance and progression of intracranial aneurysms (IA). Aneurysm (IA) Circular RNA circ_FOXO3 functions pivotally in vascular diseases and tumors, but its regulatory role as well as its molecular mechanism in IA is still uncertain. This research was to explore how circ_FOXO3 works and its mechanism in vitro model of HBVSMC IA induced by H2O2. Methods: Thirty-eight patients with IA and their normal tissues were clinically collected. Examination of endothelin-1, vascular hematoma factor, circ_FOXO3, microRNA (miR)-122-5p and KLF6 and the correlation of circ_FOXO3 with clinical case information were ensured. Establishment of an in vitro IA model was through HBVSMC induced by H2O2 and transfection with circ_FOXO3, miR-122-5p and KLF6 related plasmids was to figure out their roles in cell growth. The relationship among circ_FOXO3, miR-122-5p with KLF6 was detected. Results: Up-regulated circ_FOXO3 and KLF6 and reduced miR-122-5p were in IA tissues; Circ_FOXO3 was associated with smoking history, Hunt-Hess grading and endothelial injury degree. Repressive circ_FOXO3 or KLF6 and strengthening miR-122-5p facilitated H2O2-induced proliferation and repressed HBVSMC apoptosis, while elevation of circ_FOXO3 or depressive miR-122-5p was opposite. circ_FOXO3 bound to miR-122-5p, whose target was KLF6, which participated in controlling IA by mediating the circ_FOXO3/miR-122-5p axis. Conclusion: In summary, the findings suggest that circ_FOXO3 suppresses H2O2-induced proliferation of HBVSMC but promotes apoptosis via modulation of miR-122-5p/KLF6 axis. Targeted therapy of circ_FOXO3/miR-122-5p/KLF6 axis is supposed to be a promising treatment approach for IA patients.
Distribution of Epstein-Barr Virus and Human Herpesvirus 8 Co-Infections among Human Immunodeficiency Virus -1 Positive Patients
Authors: Marjani Arezoo , Hesamizadeh Khashayar , Bokharaei-Salim Farah , Khanaliha Khadijeh , Karbalaie Niya Mohammad Hadi , Habib Zahra , Esghaei Maryam
Published: October 2022

Background and Aims: Among Human Immunodeficiency Virus (HIV)-infected individuals, Epstein-Barr virus (EBV) and Human Herpesvirus (HHV)-8 could cause significant illness as opportunistic infections. The purpose of the present study was to evaluate the prevalence of EBV andHHV-8 in saliva specimens obtained from HIV-1 infected Iranian individuals under the Highly Active Antiviral Therapy (HAART) regimen compared with naïve patients.
Materials and Methods: A cross-sectional study was conducted on 103 HIV-1 positive patients who attended the hospitals affiliated with the Iran University of Medical Sciences, in Tehran, Iran, from 2018 to 2019. Enzyme-linked immunosorbent assay (ELISA) test was performed to evaluate HHV-8 and EBV antibodies. A conventional polymerase chain reaction (PCR) was carried out on saliva samples to detect EBV infection and a nested-PCR assay for HHV-8 infection. SPSS (version 20) was used for statistical analysis.
Results: Patients' mean age ± SD was 43.9 ± 16 (range 18-82 years), and from among 103 participants, 59 (57.3%) were male. The results of PCR showed that HHV-8 infection was found in 19 (18.4%), and EBV infection was found in 61 (59.2%) participants. Also, HHV-8 antibody was detected in 73 (70.9%), and EBV antibody in 97 (94.2%) patients. A significant association was observed between patients under treatment with HAART and HHV-8 DNA or EBV DNA infection in saliva.
Conclusions: HIV-infected patients demonstrated a remarkable rate of EBV and HHV-8 in saliva, which could have a great role in the shedding of viruses. Also, they may contribute to the establishment of further opportunistic infections and devastating complications.
A Missense Mutation in the HMNT Gene Responsible for Autosomal Recessive Intellectual Disability in an Iranian Family with Consanguineous Marriage
Authors: Mirabutalebi Seyed Hamidreza , Dehghani Mohammadreza , Ghasemi Nasrin , Vahidi Mehjardi Mohammad yahya , Movahedinia Mojtaba , Kalantar Seyed Mehdi
Published: October 2022

Background and Aims: One of the neurotransmitters in the brain is Histamine which acts as several biological mechanism regulators like inflammation, gastric acid secretion, and neuromodulation. Inactivation of Histamine occurs by histamine N-methyltransferase (HNMT) enzyme. The HNMT transfers a methyl group from S-adenosyl-L-methionine to Histamine and is the main process for the termination of neurotransmission actions of Histamine in the mammalian central nervous system.
Materials and Methods: In this case, a family was referred to the genetic clinic to diagnose the cause of their disorder. The clinical form, pedigree, and questionnaire were completed for the family, and the parents gave their written consent for all tests and photographs publication. Both siblings have moderate learning and intellectual disability. Whole exome sequencing was performed and Sanger sequencing for co-segregation was used.
Results: Bioinformatics analysis revealed a homozygous missense variant in HNMT (c.623T>C p.Leu208Pro) which causes non-syndromic autosomal recessive intellectual disability in this consanguineous family. Analysis of segregation confirmed this mutation. P.Leu208Pro mutation reduces the stability of the protein, which reduces the inactivation of Histamine.
Conclusion: HNMT should be considered an important gene in the genetic evaluation of consanguineous families with intellectual disability.
Soil Actinomycetes-derived Secondary Metabolites-Induced Apoptosis in Human Lung Cancer Cells
Authors: Norbakhsh Rahil , Gardeshi Tohid Moradi , Dalvand Sina , Boroughani Zahra
Published: October 2022

Background and Aims: Natural compounds derived from animal, plant, and microbial sources participate in treating various types of cancers, including lung cancer. This survey attempted to explore the anticancer activity of two novel metabolites extracted from soil-derived actinomycetes in the human lung cancer A549 cells.
Materials and Methods: The crude extracts of UTMC 638 and UTMC 877 secondary metabolites were obtained from the University of Tehran Microorganisms Collection (UTMC). When doxorubicin was applied as a positive control, cell viability, apoptosis detection, and mRNA expression were assessed by MTT assay, flow cytometry, and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) technique.
Results: The results of the MTT assay showed that UTMC 638, UTMC 877, and doxorubicin reduce A549 cell viability in a concentration-dependent manner. Cell treatment with UTMC 877, UTMC 638, and doxorubicin could promote apoptosis in the A549 cell line. However, the effect of UTMC 638 on apoptotic induction was more than doxorubicin or UTMC 877. The q-RT-PCR results highlighted that the gene expression associated with apoptosis was augmented in the treated group compared to the untreated group.
Conclusion: Our findings provide evidence that the crude extract of UTMC 676 could promote apoptosis in A549 cells and can be a very promising source for designing a potent antitumor agent against lung cancer cells.
Efficacy of High Dose Vitamin D on Pulmonary Artery Pressure in Thalassemia Patients Undergoing Blood Transfusion: A Randomized Trial
Authors: Eghbali Aziz , Fadayi Fatemeh , Ghandi Yazdan , Falahati Vahid , Bagheri Bahador
Published: October 2022

Background: Pulmonary arterial hypertension (PAH) may result in cardiomyopathy which is a major cause of death in thalassemia patients. Vitamin D is associated with benefits in cardiovascular disorders. Our purpose was to study effects of vitamin D on pulmonary artery pressure in thalassemia major and intermedia patients.
Materials and Methods: This randomized trial was performed on 26 patients with thalassemia major (TM) and intermedia (TI) in Amir-Kabir Hospital, Arak, Iran in 2019-2020. Patients were randomized 1:1 to intervention group (vitamin D 50,000 IU/week) and control group (received no supplement) for 20 weeks. Echocardiography was used to measure pulmonary artery pressure and assess cardiovascular function. The levels of 1,25-dihydroxyvitamin D3, ferritin, and cardiac iron content were measured in study groups.
Results: After 20 weeks, pulmonary arterial pressure (PAP), tricuspid regurgitant velocity (TRV), and pulmonary regurgitant velocity (PRV) significantly improved in the intervention group compared to the control group (P= 0.010, P= 0.003, and P= 0.001, respectively). Moreover, ejection fraction (EF) had significant increase in the intervention group compared to the control group (P= 0.008), although vitamin D supplementation had no significant impact on cardiac T2* values (P= 0.827), systolic and diastolic blood pressure (P= 0.388 and P= 0.509, respectively) and serum hemoglobin and ferritin levels (P= 0.557 and P= 0.620) as compared to the control group. However, the levels of 25-OHD3 significantly increased in the intervention group compared to the control group (P= 0.036).
Conclusion: This study showed that vitamin D 50000 IU/week can improve PAP in patients with thalassemia. Sufficient intake of vitamin D may prevent cardiomyopathies related to PAH.
Visual and Auditory Complications during Deferasirox Therapy in Beta-thalassemia
Authors: Poosheshdoost Parastoo , Faraji Niloofar , Zeinali Tahereh , Baghersalimi Adel , Miremarati Aye , Darbandi Bahram
Published: October 2022

Background:  Deferasirox is an oral iron chelator widely used to treat iron overload in patients with transfusion-dependent β-thalassemia. This study investigated the prevalence of visual and auditory complications caused by deferasirox.
Materials and Methods: This cross-sectional study included 156 patients aged less than 18 years with transfusion-dependent β-thalassemia and deferasirox iron chelator consumption admitted to the 17 Shahrivar Hospital and the Besat Clinic in Rasht, Iran. All the patients were examined for visual and auditory complications caused by deferasirox in 2019. A checklist of the patients' demographical and clinical data was recorded. Data analysis was done with SPSS and reported by descriptive statistics. Then, Fisher's exact test was performed to examine the association between visual and auditory disorders and the use of deferasirox in terms of disease-related variables including age, sex, age of onset of using chelator, drug use duration, drug dosage, and mean 6-months serum ferritin levels (P <0.05 as the significance level).
Results:  Of a total of 156 patients, 103 (66%) were female and 56 (35.9%) were 20-30 years of age. The prevalence of visual acuity change was 0.6%, and the prevalence of sensorineural hearing loss was 1.3%. There was only one female with the visual disorder decreasing to 9/10 and with a dose of 31-40 mg/kg/day with an average of 1000-2500 ng/ml six-month ferritin. Also, two females with hearing impairment were confirmed with a dose of ≤30 mg/kg/day, and an average of ≤1000 ng/ml six-month ferritin. The Fisher's exact test results showed no significant relationship between visual and auditory disorders with the use of deferasirox in terms of disease-related variables (p>0.05).
Conclusion: The study's findings showed no significant relationship between visual and auditory disorders with deferasirox consumption. The results indicated the safety of deferasirox regarding visual and auditory side effects. More studies are required to confirm the findings.
The Effect of L-Glutamine on Pain Crisis Reduction in Patients with Sickle Cell Anemia and Sickle β°-Thalassemia
Authors: Farmani Anoosheh Neda , Keikhaei Beijan
Published: October 2022

Background: A low level of L-glutamine, a precursor of nicotinamide adenine dinucleotide (NAD) in red blood cells (RBCs), is identified as an underlying mechanism for the potential decrement of the NAD redox and the incidence of pain crisis in sickle cell anemia (SCA). The aim of this study is to assess the impact of oral L-glutamine therapy on pain crisis reduction in patients with SCA and sickle β°-thalassemia.
Materials and Methods: In this pilot clinical trial, 15 patients with SCA and sickle β°-thalassemia with the mean age of 17.2 ± 6.07 were examined to evaluate the efficacy of L-glutamine therapy in pain crises. All the subjects received oral L-glutamine (0.3 gr /kg of body weight) every day for 8 weeks. With respect to the effects of L-glutamine on pain crisis, the subjects were in contact with the physicians at least once or more per week. Blood samples were taken at different follow-up times to evaluate the laboratory characteristics of the patients.
Results: Pain crises occurred for 1-3 times (mean: 1.29 ± 1.05) during 12 months before the L-glutamine therapy. With no significant change, the patients had lower numbers of painful crises (mean: 0.80 ± 0.58) at the end of a 4-week period compared to the period before the L-glutamine therapy (P = 0.466). Fewer pain crises with a mean of 0.33 ± 0.51 occurred during 8 weeks of L-glutamine therapy than in the pre-treatment period (P = 0.038).
Conclusion: The results of the present study showed that oral L-glutamine can mitigate a pain crisis and improve the sickle RBCs and reticulocyte count in SCA. This suggests that L-glutamine therapy can increase the antioxidant potential of sickle RBCs.
Czyn czy słowo – co leży u podstaw filozofii pierwszej?
Authors: Pokorski Bartosz
Published: October 2022

W niniejszym tekście porównuję filozofię bytową, kto rej modelowym przykładem jest filozofia Arystotelesa, z filozofią czynu zaproponowaną przez Stanisława Brzozowskiego. Te dwie konstrukcje ro z nią się co do punktu wyjścia rozważań . Pierwsza z nich obiera słowo jako początek, druga zaś czyn. W tekście starałem się pokazać kontrast między tymi stanowiskami i konsekwencje w uprawianiu filozofii wypływające z przyjętych założeń . Omawiam różnice pomiędzy filozofią zajmującą się przedmiotami s wiata rzeczy, obecnie stającą się metanauką, a filozofią kultury, która zajmuje się podmiotem i historycznie stworzonym przez pracujące pokolenia światem ludzkiego doświadczenia. Zaznaczenie tej różnicy jest niezbędne jeśli chcemy postawić filozoficzne pytanie o kryzys kultury.
New atheism and secularism
Authors: Sieczkowski Tomasz
Published: October 2022

The paper attempts to analyze the theoretical conditions of the possible conflict between the New Atheism and modern secular liberal democracies. After short presentation of a few main components of neoatheistic thinking I concentrate on the notion of secularism as proposed by Charles Taylor. I conclude that by identifying the religion as “the root of all evil” the New Atheists are revealing the unjustifiable lack of judgment, as their aggressive antireligious stance generates rather crises and conflicts than social harmony.
Transhumanizm polityczny – przyszłość bez kryzysu?
Authors: Misztal Dawid
Published: October 2022

Jak ma to miejsce w przypadku każdej utopijnej wizji przyszłości, także transhumanizm przynosi pewne propozycje o charakterze społeczno-politycznym. W ostatnich latach po obu stronach Atlantyku zwolennicy tego nurtu podjęli starania, aby idee te znalazły swoją reprezentację w politycznym mainstreamie. W tekście przyglądam się zestawowi charakterystycznych dla politycznego transhumanizmu przekonań, by ocenić ich potencjalną atrakcyjność i efektywność w rozwiązywania problemów, jakim miałyby w domniemaniu zaradzić. W tym celu staram się najpierw przybliżyć ogólną specyfikę politycznego wymiaru transhumanizmu, by następnie wyróżnić dwie dominujące w nim orientacje: technolibertarianim i technoprogresywizm. Na tak zarysowanym tle scharakteryzowane zostaje funkcjonowanie pojęcia kryzysu w retoryce i postulatach politycznych transhumanizmu.
Problem relacji umysł-ciało w emergentyzmie Samuela Alexandra
Authors: Fornal Marzena
Published: October 2022

Wśród współczesnych filozofów umysłu dominuje przekonanie, że klasyczny emergentyzm dążył do utworzenia całościowego systemu metafizycznego niejednokrotnie dopuszczając istnienie nie fizycznych czynników czy sił. To przekonanie, klasyfikujące brytyjski emergentyzm, jako stanowisko stojące w sprzeczności z powszechnie przyjmowaną współcześnie tezą o domknięciu przyczynowym świata fizycznego, przyczynia się do całkowitej jego dyskredytacji we współczesnych debatach nad problemem umysł-ciało. Celem niniejszego artykułu jest zaprezentowanie metafizyki umysłu Samuela Alexandra, jednego z czołowych przedstawicieli wymienionego wyżej stanowiska filozoficznego oraz analiza jego współczesnych interpretacji. Główną tezą pracy jest twierdzenie, że zaproponowane przez Alexandra rozwiązanie problemu umysł-ciało, można z powodzeniem przenieść na grunt współczesnych rozważań w ramach tak zwanego nieredukcyjnego fizykalizmu.
W obronie pojmowania przyjemności jako uczucia
Authors: De Lazari-Radek Katarzyna
Published: October 2022

Gilberta Ryle oraz Fred Feldman definiowali przyjemność jako, odpowiednio, dyspozycję i nastawienie sądzeniowe. Zastanowię się, czy ich koncepcje mogą poważnie zagrażać tradycyjnemu pojmowaniu przyjemności w kategoriach uczucia albo doznania. Skłaniać się będę ku tezie, że niechęć Ryle’a i Feldmana do traktowania przyjemności jako pewnego rodzaju stanu umysłu wynika z niezrozumienia różnicy między doznaniem a uczuciem. Pojęcia te odnoszą się do różnych zjawisk psychicznych i nie powinny być używane wymiennie. Ukazanie i zrozumienie różnicy między nimi pozwoli mi bronić pojmowania przyjemności w kategoriach uczucia, choć nie doznania.
Update on the Pathogenesis, Virulence, and Treatment of Candida auris
Authors: Watkins Richard R. , Gowen Rachael , Lionakis Michail , Ghannoum Mahmoud
Published: October 2022

Candida auris is an emerging, multi-drug resistant fungal pathogen that causes considerable morbidity and mortality. First identified in Japan in 2009, it has since been reported in more than 40 countries. C. auris can persist for long periods on different environmental surfaces as well as the skin. Clinical isolates are typically resistant to commonly prescribed antifungal drugs. Increasingly recognized as a cause of infections and outbreaks in nosocomial settings, C. auris is difficult to identify using traditional microbiological methods. One of the main reasons for the ongoing spread of C. auris is the multitude of virulence factors it possesses and uses against its human host that enables fungal persistence on the skin surface. Yet, many of the virulence mechanisms are unknown or remain incompletely understood. In this review, we summarize the evolution of virulence of C. auris, offer recommendations for combating this important human pathogen, and suggest directions for further research.
Late frost protection – what to retain from the Champagne experience?
Authors: Pauthier Basile , Debuisson Sébastien , Descôtes Arnaud
Published: October 2022

With the occurrence of frost, sensitive plants are susceptible to damage. One of the most counter-intuitive impacts of climate change is the increasing frequency of spring frost.  Studies have warned of this problem (Inouye, 2008), describing an earlier budburst due to higher temperatures during winter and the last day of frost remaining around the same date. The risk of polar jet stream destabilisation by quick warming has also been mentioned (Molitor et al., 2014). Since 2016, Western European vineyards have suffered from frost damage almost every year (Rochard et al., 2019).
Linkage of Monetary Policy and Islamic Capital Market: The Case of Indonesia
Authors: Quthbi Zainul Hasan
Published: October 2022

The study aims to examine the linkage of monetary policy and the Islamic stock market in Indonesia. Monetary policy variables are used in this study, namely, interest rate, exchange rate, and money supply (M2). Besides, the foreign interest rate is included as measured by FFR. At the same time, the shari’a index is used, namely Jakarta Islamic Index (JII). In the analysis, this study adopts the cointegration test, Granger causality test, and VECM. This study showed a negative long-term relationship between the variable interest rate and M2 to the JII stock price. The exchange rate variable has a positive long-term relationship with the JII stock price. While the foreign interest rate variable has a short-tem relation to the JII stock price, it doesn’t have a long term relationship.Keywords: Monetary Policy, Capital Market, Jakarta Islamic Index, Linkage
Contribution of KH. MA. Sahal Mahfudh to Community Economic Empowerment
Authors: Prasetyoningrum Ari Kristin , Darojat Muhammad Irhas
Published: October 2022

This article aims to analyze the contribution of KH. MA. Sahal Mahfudh in empowering the economy of the community which is motivated by conditions of unresolved poverty. This article is a library research using a sociological-historical approach. Data collection methods in this study using documentation and interviews. The analysis of this research uses qualitative analysis. The results of this study indicate that the contribution of KH. MA. Sahal Mahfudh in community economic empowerment can be a solution to poverty problems. The Islamic boarding school led by Kiai Sahal has become the driving force for the economic empowerment program for the surrounding community by developing various business units. The business units established by Kiai Sahal include: BPR Artha Huda with conventional systems, BPR Artha Mas Abadi using the sharia system, printing businesses (Masda Grafika and Masda Digital Printing), Rambutan Gardens, and Walet Enterprises.
Creating Sharia Capital Market Literation Strategy on Social Media among Young Moslem
Authors: Puspita Rosana Eri , Saifudin Saifudin
Published: October 2022

This study aims to create a sharia capital market literation strategy on social media among young Moslem based on influence from social media influencer, social presence, and trustworthiness. The approach taken in this research is quantitative. Data is collected with the help of research instruments in the form of online questionnaires. The population in this study is the young Moslem who tends to be a social media. The sample size in this study was113. The testing tool in this study used SPSS and a regression test was conducted to determine the effect of this research variable. The results show that social media influencers, social presence, and trustworthiness have a significant effect on intention-to- learn sharia capital markets. The study suggests many programs to create sharia capital market literation on social media among young Moslem.
Comparative Study in Zakat Management between Pusat Zakat Sabah and Badan Amil Zakat DIY
Authors: Fairi Maulana Ihsan
Published: October 2022

Zakat is one of the basic principles that can be used as an instrument to reduce poverty and help Muslims in need. However, the participation of Muslims in Indonesia to paying zakat is still very less, in 2015 only IDR 2.477.457.839.898 which is collected from 207.176.162 Muslim population. Compared with Malaysia in 2015 collected more than MYR 2.334.010.085 or equivalent to IDR 7.002.030.257.000 of 17.375 million Muslim population. It makes this research aim to know the difference between zakat management in Indonesia and Malaysia. To compare it is selected Pusat Zakat Sabah (MUIS) with total collection in 2015 as much as MYR 795.695,17 or equivalent IDR 219.939.753.999 and Badan Amil Zakat DIY with total accumulation in 2015 amounting to IDR 680.990.478. Both are equivalent as zakat institutions at the provincial level. With descriptive qualitative method, it is used to describe data related to zakat management in PZS and Baznas DIY which have been collected. From the descriptive analysis, PZS has advantages in terms of collection and distribution, with the amount of funds collected and the absorption of fund distribution is always exhausted. Then in terms of utilization and Supervision of PZS and Baznas DIY have their respective advantages.
The Concept of Advertisement: An Islamic Perceptive
Authors: Begum Azeema
Published: October 2022

There is a general perception regarding advertisement that advertising has a strong influence on consumer behavior. Advertisement has an imperative role in changing the social and cultural values of society. For convincing and getting consumer’s attention, advertising is considered the most successful and influential way of transforming information regarding new products. The paper argues the concept of advertisement in the light of Islamic Sharia’h.  We have found no evidence of any restriction for using advertisement as a promotional tool for products however; Islam has defined a certain set of laws that should be considered while making advertisements. Moreover, this paper also highlights some unethical issues of contemporary advertisement which are prohibited in Islam.
Ethno-Religious Voting Pattern and Governance in the Post-2015 Presidential Election in Nigeria
Authors: Agbo Joy Nkiru , Nnamani Kelechi Elijah , Nnadi Christian Ikechukwu
Published: October 2022

This study therefore examined the link between the ethno-religious voting pattern in the 2015 presidential elections and governance in the post-election era in Nigeria. We anchored our analysis on the Rational Choice Theory and relied on documentary method where data were systematically gleaned from journal articles, newspapers, official documents and other online materials while utilizing content analysis as our analytical compass. Based on this, we hypothesized as follow: the ethno-religious voting pattern in the 2015 presidential election has affected political development of Nigeria under the Buhari administration; the regionalization of political appointments by Buhari administration has increased ethno-regional agitations in Nigeria. On this note, the study found that ethno-religious voting pattern played vital role in determining the pace of governance and how resources should be distributed among the competing ethnic nationalities in the post-election era. It is however, recommended that the electorates should embrace party ideology and competence of candidate as the guiding factor for voting in the future elections to be held in Nigeria.
The Influence of Gross Enrollment Ratio (GER) on the Literacy and Inclusion Index: A Case Study of Islamic Finance in Indonesia
Authors: Hasan Zulfikar , Sulaiman Ahmad Azam , Putri Mutia Rosiana Nita
Published: October 2022

The inclusion and literacy of Islamic finance is an index that can use as a guide in assessing whether people living in a country know about Islamic finance. Multiple variables can conclude whether a nation knows Islamic banking. The Financial Services Authority does a review that can use as additional analysis on the knowledge of the Indonesian personalities about Islamic Banking. Overall, the Third National Financial Literacy Survey (SNLIK) accompanied by the Financial Services Authority (OJK) this year revealed that the financial literacy index equaled 38.03%, including the financial inclusion index of 76.19%. Based on geographical levels, during urban financial literacy index equaled 41.41% and economic inclusion of urban ranges amounted to 83.60%. OJK will use the results of the 2019 financial literacy survey to improve the national financial literacy developing policy that is further practical and targeted. In comparison, the literacy index and financial inclusion of rural communities were 34.53% and 68.49%. This pattern developed compared to the results of the 2016 OJK survey, precisely the financial literacy index 29.7% and the financial inclusion index 67.8%. The questionnaire effects further designated that based on gender literacy index and economic inclusion of men were 39.94% and 77.24%, comparatively higher than women at 36.13% and 75.15%.
The Rights to Freedom of Belief Based on Pancasila
Authors: Waringga Kristoforus Farian , Muchtar Adjuan Sudjana
Published: October 2022

Pancasila is the legal basis and ideology of Indonesia, which regulates all existing laws, including the freedom of belief. The Indonesian state was founded by national warriors of ethnic, language, cultural, customary, and religious diversity, thereby necessitating the people to exhibit mutual respect and appreciation. Therefore, this research aims to discover the meanings, values, and appropriate practices of the first Pancasila precepts in order to guarantee the right to freedom of belief, religion, and worship. The legal or normative juridical research method was employed by observing previous events and cases and analyzing them with a statutory approach. Subsequently, the results showed that the right to freedom of religion is regulated in the first precepts of Pancasila, where every citizen has the right to choose, embrace, and practice worship according to their beliefs. Hence, every society should cultivate a sense of unity in diversity by respecting and appreciating other religions, as the existence of all beliefs is guaranteed by law and the state.
Effect of Food Review in Zomato Applications as eWOM on Customer Purchase Intention
Authors: Zunvindri Zunvindri , Natasha Natasha , Abdurrachman Edi
Published: October 2022

Eating is no longer just to meet the needs, but also become an activity of socializing. With the increasing number of places to eat in Indonesia, encourage people to find a recommendation for a place to eat before deciding to try the food at the eating place. But, when it came to the internet and smartphone, people can easily get digital recommendation information, in the form of reviews provided by those who like to share their dining experiences (foodies). This digital recommendation is then called Electronic Word of Mouth. However, the review given digitally or online has its drawbacks, less objective, ending with a disappointing experience. This research objective is to discuss the effect of using Zomato on users' intentions to purchase or try food or restaurants. Descriptive quantitative approach and complete technique of survey data using questionnaire would be executed. Data analysis in this research is descriptive statistic and regression. Results obtained are information quality, information credibility, need of information, and attitude toward information have positive influence on information adoption. Moreover, information adoption also has positive influence on customer purchase intention. The conclusion from this study shows the variables that are interconnected and affect each other.
A Fragmented Approach to Indonesia's Decentralized Urban Slum Reduction Policy: Central Java's Case
Authors: Arifin Saru
Published: October 2022

The Indonesian government, through the Ministry of Public Works and Public Housing ('PUPR'), launched a significant campaign in 2015-2019 to eradicate slums from Indonesian cities, termed "Kota Tanpa Kumuh" ('Kotaku') or City Without Slums. While this endeavor has succeeded in physically reducing the number of slums in Indonesia, the objective of totally eliminating slums within that time frame is unattainable. Many Indonesian municipalities continue to have slum communities with a variety of socioeconomic effects. The article argues, through the use of a case study in Central Java Province, that the government's failure to achieve its objective of zero slums in Indonesian cities is due to the Kotaku program's approach being incompatible with that of other ministries. Due to the fact that the problem of slum settlements encompasses a range of societal concerns such as poverty, low income, culture, and even criminality, merely altering the housing in which people live from uninhabitable to respectable is insufficient. Meanwhile, the root causes of slums continue to be ignored. As a result, this article proposes that slum eradication be integrated and sustainable through the continual involvement of numerous essential parties, including NGOs and universities.
Preparation of Future Masters of Pedagogical Directions for the Socio-Cultural Education of Students
Authors:   Transbaikal State University, Svetlana V. Shendeleva , Lyudmila S. Romanova ,   Transbaikal State University
Published: October 2022

The article reveals the problem of training masters of pedagogical directions, its importance for the implementation of socio-cultural education of students. The urgency of the problem is due to a decrease in attention to the spiritual and moral education of the younger generation, which includes various value orientations that contribute to the education of the student’s personality. The authors analyze the approaches to solving the problem in modern conditions and propose a training course “Socio-cultural education of students” for the implementation of the training of masters of pedagogical directions, which examines the issues of socio-cultural education of students who form a responsible attitude to their family, society, people and shows the close relationship of socially successful socialization of the individual in the educational space of culture. Within the framework of the developed discipline included in the curriculum for the preparation of master’s students in the direction 44.04.01 Pedagogical education, the master’s program “Safety in the technosphere and in educational institutions” implements a practice-oriented approach aimed at the socio-cultural education of students and their preparation as future teachers for the socio-cultural education of students. The course content includes the issues of socio-cultural education of students from the standpoint of cultural, competence-based, systemic, personality-oriented, axiological, event-based and integrative approaches, as well as social knowledge about the individual, society and civilization, and the application of the acquired knowledge in their pedagogical professional activities. The article presents a historical and pedagogical analysis of the state’s attitude to the formation of the personality of students in the context of the formation of pedagogical science, experience and scientific research of contemporaries on the problem of socio-cultural education, as well as the results of the introduction of the course “Socio-cultural education of students”, problems and prospects of its development for the preparation of future masters of pedagogical directions for the socio-cultural education of students.
Formation of Civic Qualities of Modern Students Through Project-Educational Intensive
Authors:   Buryat State University named after D. Banzarova, Bayaskhalan Ts. Banzaraktsaev
Published: October 2022

This article discusses the experience of forming the civic qualities of today’s youth. Citizenship and socially significant qualities have become more relevant than ever before in the light of recent political events. In the article, the author relies on the works of both the classics of Soviet and Russian Pedagogy, as well as the latest works of scientific teachers devoted to the problem of socially significant civic qualities of young people. Various positions are considered in relation to the category of citizenship, the relationship between the terms citizenship and patriotism is determined. The definition of the category “citizenship” and the essential content of this category are given. Civic qualities, in our opinion, characterize the ability of an individual to actively manifest their civic position through socially significant, practice-oriented activities. The experience of conducting an acceleration program for the development of socially oriented student initiatives is analyzed. Within the framework of project-educational intensives, a full cycle of search, selection, evaluation, examination, support and monitoring of projects takes place. The influence of participation in the acceleration program, development of project ideas, discussion and presentation of projects, as well as the implementation of projects on the degree and level of civic consciousness of student youth is studied using the example of an experimental group of students who participated in the accelerator of student projects. The structure of the acceleration program is considered, the stages of implementation are determined, and examples of specific student projects are given. The practice of holding events aimed at the formation of civic qualities of student youth is generalized. The results of the survey materials of the control and experimental groups are presented and analyzed. The recommendations are given for the further systematic implementation of project-educational intensives, acceleration programs aimed at the development and implementation of student projects and the development of student citizenship.
Teacher Training for the Formation and Evaluation of Functional Literacy of Students in the Process of Individualized Professional Development
Authors:   Academy “Education”, Natalya I. Volynchuk
Published: October 2022

Education today faces many challenges caused not only by the high rates of technology development, but also by the rapid changes in the political and socio-economic situation in the world. A graduate of a modern school should be able to use his constantly updated knowledge and skills to solve a wide range of life tasks, i. e. he should have a sufficiently high level of functional literacy. However, international comparative studies record an insufficient level of functional literacy among Russian schoolchildren. The formation of functional literacy of students is becoming one of the main tasks of a modern school. The problem of individualized teacher training for the formation and evaluation of functional literacy in the process of professional development has not been raised and has not been solved. The purpose of this article is to reveal a variant of individualized teacher training for the formation and evaluation of functional literacy of students through the description of the content of an additional professional program designed on the basis of the modular principle. The methodological basis of this study is the acmeological approach, since it allows us to study the patterns of professional development of teachers in the process of professional development, as well as the principles of andragogy formulated by domestic and foreign scientists. The article describes a variant of the implementation of a modular additional professional program, the content of invariant and variable modules aimed at the formation of psychological, theoretical and practical readiness of teachers for the formation and evaluation of functional literacy of students. The described variant of individualized teacher training for the formation and evaluation of functional literacy of students can be used to design additional professional programs in various areas of development of Russian education, and will also be useful to researchers engaged in the search for effective options for preparing teachers for any direction of professional activity in the process of professional development.
The Method of Measuring Radiation Spectra in the Course Work in Physics
Authors:   Transbaikal State University, Anatoly P. Druzhinin , Tatiana V. Kuzmina ,   Transbaikal State University
Published: October 2022

The article provides the justification for the implementation of coursework in physics in the system of methodological training of bachelors, carried out in the context of the implementation of the Federal Educational Standard, higher education in the direction of 44.03.05 Pedagogical education (with two training profiles). The authors single out the formation of research skills as one of the most important aspects of teaching future physics teachers. The specifics of the course work on the subject of “General Physics” are revealed, which contribute to the consolidation and generalization of theoretical knowledge, the application of this knowledge to the complex solution of specific research tasks, increasing the level of subject competence in physics. In this article, the possibility of measuring radiation from various light sources in the visible region of the spectrum is considered, based on the study of the spectral composition of the radiation source under study with subsequent information processing. The authors propose to use the considered method of measuring radiation spectra when performing coursework in general physics. The authors describe the conditions of the experiment and give a diagram of the working installation. Measurements of the radiation spectra are carried out using a monochromator and a photodetector pre-graded in transmission and spectral sensitivity. The examples of the emission spectra of a green LED, a red semiconductor laser and a fluorescent lamp measured by the considered method are given. The research methodology, proposed by the authors, helps students to learn how to work with spectral measuring equipment, measure and plot the emission spectra of light sources, calculate the width of the monochromator slit at which the spectra are measured and estimate the measurement error. The recommendations of similar experiments are given when performing students’ term papers.
Experimental study on creep wetting of silty clay
Authors: Qi Dahe , Yang Jianxin , Liu Yuehan
Published: October 2022

To study the wetting of a silty clay subgrade in an expressway, many laboratory tests were carried out. The test results show that the creep deformation of silty clay under water immersion cannot be ignored, but it is different from the deformation caused by wetting. The creep properties of soil mass are affected by many factors. Under different stress conditions, the soil mass will show different properties. In order to study the creep characteristics of silty clay in Chongqing under water wetting and different stress levels, a series of triaxial water wetting creep tests were carried out. The Singh-Mitchell creep equation was introduced to establish the creep model of silty clay drainage in Chongqing, and the parameters of the model were discussed.
Shared Interoperable Clinical Decision Support Service for Drug-Allergy Interaction Checks: Implementation Study
Authors: Jung Sungwon , Bae Sungchul , Seong Donghyeong , Oh Ock Hee , Kim Yoomi , Yi Byoung-Kee
Published: October 2022

Background

Clinical decision support (CDS) can improve health care with respect to the quality of care, patient safety, efficiency, and effectiveness. Establishing a CDS system in a health care setting remains a challenge. A few hospitals have used self-developed in-house CDS systems or commercial CDS solutions. Since these in-house CDS systems tend to be tightly coupled with a specific electronic health record system, the functionality and knowledge base are not easily shareable. A shared interoperable CDS system facilitates the sharing of the knowledge base and extension of CDS services.

Objective

The study focuses on developing and deploying the national CDS service for the drug-allergy interaction (DAI) check for health care providers in Korea that need to introduce the service but lack the budget and expertise.

Methods

To provide the shared interoperable CDS service, we designed and implemented the system based on the CDS Hooks specification and Health Level Seven (HL7) Fast Healthcare Interoperability Resources (FHIR) standard. The study describes the CDS development process. The system development went through requirement analysis, design, implementation, and deployment. In particular, the concept architecture was designed based on the CDS Hooks structure. The MedicationRequest and AllergyIntolerance resources were profiled to exchange data using the FHIR standard. The discovery and DAI check application programming interfaces and rule engine were developed.

Results

The CDS service was deployed on G-Cloud, a government cloud service. In March 2021, the CDS service was launched, and 67 health care providers participated in the CDS service. The health care providers participated in the service with 1,008,357 DAI checks for 114,694 patients, of which 33,054 (3.32%) cases resulted in a “warning.”

Conclusions

Korea’s Ministry of Health and Welfare has been trying to build an HL7 FHIR-based ecosystem in Korea. As one of these efforts, the CDS service initiative has been conducted. To promote the rapid adoption of the HL7 FHIR standard, it is necessary to accelerate practical service development and to appeal to policy makers regarding the benefits of FHIR standardization. With the development of various case-specific implementation guides using the Korea Core implementation guide, the FHIR standards will be distributed nationwide, and more shared interoperable health care services will be introduced in Korea.