bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH PENGGUNAAN EXPLAINER VIDEO TERHADAP MOTIVASI BELAJAR SISWA MATA PELAJARAN BAHASA INDONESIA KELAS X UPW
Authors: Rizki Athala Merlinva Putri  , Zul Anwar  , Ary Purmadi
Published: August 2023

Berdasarkan hasil observasi dan wawancara yang dilaksanakan di SMK Negeri 1 Lingsar pada tanggal 20 November 2021, peneliti menemukan beberapa masalah yang dihadapi sekolah terkhusus pada pembelajaran Bahasa Indonesia, yaitu Guru masih mengunakan media cetak seperti buku paket, pengunaan TIK dalam pembelajaran belum maksimal, masih kurangnya guru dalam memanfaatan fasilitas yang telah tersedia di sekolah. Adapun tujuan dari penelitian ini adalah Untuk Mengetahui Pengaruh Penggunaan Explainer Video Tehadap Motivasi Belajar Siswa Pada Mata Pelajaran Bahasa Indonesia Kelas X UPW di SMKN 1 Lingsar Kabupaten Lombok Barat Tahun Pelajaran 2021/2022. Metode pengumpulan data yang digunakan dalam penelitian ini adalah angket sebagai metode pokok, observasi, wawancara dan dokumentasi sebagai metode pelengkap. Teknik analisis data menggunakan analisis statistik dengan rumus chi square. Hasil analisis diperoleh nilai = 26,735 sedangkan nilai chi square dalam tabel dengan db= 4 dengan taraf signifikansi 5% = 9,488 dengan demikian bahwa nilai chi square analisis lebih besar daripada nilai chi square tabel (26,735> 9,488). Sungguh dapat disimpulan bahwa hasil penelitian ini “signifikan”.
UPAYA PENGGUNAKAN METODE ROLE PLAYING DALAM MENINGKATKAN PRESTASI BELAJAR SISWA PADA MATA PELAJARAN BAHASA INDONESIA DI SMPN 5 KOTA BENGKULU
Authors: Rodhiah
Published: August 2023

Tujuan penelitian ini adalah meningkatkan prestasi belajar Bahasa Indonesia dengan metode Role Playing bagi siswa Kelas VIII SMP Negeri 5 Kota Bengkulu tahun pelajaran 2021/2022. Penelitian ini menggunakan pendekatan deskriptif kualitatif. Jenis penelitian yang digunakan adalah penelitian tindakan kelas dengan teknik pengumpulan data melalui tes, observasi, dan dokumentasi. Subyek yang diteliti adalah siswa kelas VIII E SMP Negeri 5 Kota Bengkulu tahun pelajaran 2021/2022 yang berjumlah 25 orang. Teknik analisis data ini menggunakan analisis data dengan model interaktif, dan dalam kegiatan analisis serta kegiatan pengumpulan data menggunakan 2 siklus yaitu siklus I dan siklus II. Hasil penelitian menunjukkan bahwa: (1) penerapan metode Role Playing dalam pembelajaran mata pelajaran Bahasa Indonesia dapat meningkatkan prestasi belajar siswa Kelas VIII SMP Negeri 5 Kota Bengkulu tahun pelajaran 2021/2022. Peningkatan prestasi belajar ini dapat dilihat dari prestasi belajar Bahasa Indonesia setelah melalui tahapan Pra Siklus, Siklus I dan Siklus II, setelah dilakukan tindakan pada tahap Pra Siklus = 69,48, tahap Siklus I = 70,60, dan tahap Siklus II = 85,72, (2) penerapan metode Role Playing dapat meningkatkan ketuntasan belajar mata pelajaran Bahasa Indonesia siswa Kelas VIII SMP Negeri 5 Kota Bengkulu tahun pelajaran 2021/2022, hal ini bisa dilihat dari peningkatan ketuntasan belajar siswa sebagai berikut: pada tahap pra siklus = 32%, tahap siklus I = 36% dan pada tahap Siklus II = 92%, dan (3) metode Role Playing dapat meningkatkan prestasi belajar dan ketuntasan belajar mata pelajaran Bahasa Indonesia siswa Kelas VIII SMP Negeri 5 Kota Bengkulu tahun pelajaran 2021/2022.
THE PARTICIPATION OF ISLAMIC RELIGIOUS EDUCATION TEACHERS IN FORMING AN ATTITUDE OF INTER-RELIGIOUS TOLERANCE
Authors: Nada Nazopah  , Hamdani
Published: August 2023

This study aims to determine the role and responsibilities of a teacher towards students who not only transfer knowledge through learning materials in the classroom but also by providing education that impacts their attitudes and behavior. SMPN 1 Gunung Sari is a junior secondary education institution that facilitates students from various economic, social, and religious backgrounds, namely Islam, Hinduism, and Christianity. This research is qualitative descriptive research which is further carried out using a case study design, namely field research using observation, interview, and documentation methods. The results of research on the role of PAI teachers in forming inter-religious tolerance attitudes at SMP Negeri 1 Gunung Sari are carried out by maximizing the teacher's function as an educator, motivator, and evaluator. These forms of tolerance include respecting greetings, mutual love, a high sense of concern, cooperation, and mutual respect and respect. Supporters were forming this tolerance attitude, namely the existence of adequate worship facilities, the realization of Cooperation Factors among school members in religious activities, and a conducive school atmosphere.
PENERAPAN METODE IBC DALAM PUBLIC SPEAKING UNTUK MENINGKATKAN KEMAMPUAN BERBICARA EFEKTIF PADA PNS PADA BKPSDM KABUPATEN SUKABUMI
Authors: Hesri Mintawati  , Wiwin Winarni  , Nur Rita Handayani  , Kohar Pradesa  , Rina Heryani
Published: August 2023

Tujuan penelitian ini untuk mengetahui kompetensi public speaking pada aparatur sipil negara yang merupakan syarat mutlak untuk meningkatkan kualitas sumber daya manusia dalam hal meningkatkan para eselon 3 pada BKPSDM kabupaten sukabumi, terutama public speaking dengan menggunakan metode IBC. Berdasarkan rekapitulasi aparatur sipil negara (ASN) pemerintah kabupaten sukabumi berdasarkan jenis jabatan, total keseluruhan structural dan fungsional berjumlah 9.774, sedangkan kondisi pegawai negeri sipil di sukabumi berdasarkan data sebanyak 12.149 orang dengan rincian jabatan structural 931 orang atau 9,35% dan jabatan fungsional tertentu sebanyak 6,03 orang atau 67,56% dan jabatan fungsional umum berjumlah 2240 orang atau 22,92%. Selain PNS ada juga pegawai pemerintah dengan perjanjian kerja atau (PPPK) sebanyak 2375 orang. Jumlah PNS yang cukup besar, jelas membawa kontribusi yang besar bagi pengembangan sumber daya manusia namun terbilang Sebagian besar memiliki kinerja yang buruk data kementrian pendayagunaan aparatur negara dan reforma Birokrasi (Kemenpan-RB). Hampir 30% atau sekitar 1,35 juta PNS memiliki kinerja yang tergolong belum maksimal, belum tau tugas hingga tidak memahami kewajibannya. BKPSDM merupakan liding sector pengembangan sumber daya manusia dibidang softskill yang dipimpin oleh kepala badan pelatihan sumber daya manusia bapak Dadang Budiman agar para ASN diberikan pelatihan tentang public speaking dapat meningkatkan kepercayaan diri dan dapat berbicara secara professional teratur, terstruktur, terukur. Mengacu pada tiga komponen penting pada public speaking, visual, verbal, dan vocal. Metodelogi penelitian ini secara kualitatif menggunakan data primer dan data sekunder dengan wawancara, hasil pengamatan dan dokumentasi dan kordinasi serta kerja sama sedangan Teknik pelatihan bimtek public speaking pelatihan langsung dengan metode pelatihan ceramah, tanya jawab, brain storming, simulasi, penayangan video, serta konsep kesiap siagaan bela negara. Hasil pelatihan ini dapat menghasilkan peserta terbaik dengan nilai ujian praktek menunjukan bahwa 70% dari jumlah peserta menunjukan peningkatan yang signifikan tentang berbicara yang professional.
Pelatihan Tentang Perkembangan Anak Bagi Guru PAUD
Authors: Nuraeni  , Endriani Ani
Published: August 2023

Tujuan pengabdian ini adalah untuk untuk memberikan pelatihan bagi Pendidik dan Tenaga Kependidikan (PTK) Anak Usia Dini dalam rangka menyiapkan dan meningkatkan kompetensi dan profesionalisme pedagogi guru PAUD yang berkualitas di Kabupaten Biak Numpor Papua, berupa memahami perkembangan anak, mengenali tugas perkembangan anak dan kemampuan menerapkan konsep-konsep tentang perkembangan anak. Harapan dari kegiatan pelatihan ini bagi guru PAUD adalah dapat memahami  dengan tepat mengenai pertumbuhan dan perkembangan anak, mengenali tugas perkembangan anak, memahami tahapan perkembangan anak sesuai dengan usianya serta memberikan pendidikan dan pengasuhan yang tepat sesuai dengan tahapan perkembangan anak.

Kata kunci: Pelatihan Karakter Kepemimpoinan, Generasi Millenials
PEMBERDAYAAN MASYARAKAT MELALUI APOTEK HIDUP BERBASIS LIMBAH ORGANIK DI DESA MONTONG BAAN KABUPATEN LOMBOK TIMUR
Authors: Muhamad Suhardi, Zinnurain Muhamad Suhardi, Zinnurain
Published: August 2023

Tujuan dari kegiatan pengabdian kepada masyarakat ini adalah melaksanakan Pengabdian Kepada Masyarakat; Pemberdayaan Masyarakat Melalui Apotek Hidup Berbasis Limbah Organik di Desa Montong Baan Kecamatan Sikur Kabupaten Lombok Timur. Kegiatan ini dilaksanakan secara kolaborasi (berkelompok) dengan tim kecil. Adapun metode dan prosedur pelaksanaan kegiatan antara lain: 1) Melakukan wawancara dengan mitra dan masyarakatsekitar. 2) Melakukan koordinasi dengan Pemerintah Desa. 3) Melakukan observasi. 4) Melakukan sosialisasi/edukasi kepada masyarakat. 5) Mendokumentasikan proses dari program yang dijalankan. Begitu juga metode yang di gunakan dalam Pelaksanaan dilakukan dalam tiga tahap, yaitu; 1) Tahap persiapan.2) Tahap pelaksanaan. 3) dan Tahap akhir. Tahap sosialisasi meliputi: 1) Menyiapkan kebutuhan untuk melakukan kegiatan pelaksanaan pemberdayaan. 2) Melibatkan warga membantu dan memberi pendapat. 3) Menerima masukan atau kekurangan saat kegiatan pemberdayaan. Selanjutnya tim dan warga mempersiapkan alat dan bahan. Berdasarkan jadwal kegiatan di atas, maka hasil kegiatan yang diperoleh antara lain yaitu: 1) Tim pemberdayaan dapat memberikan pelayanan dengan kenyamanan dan kepuasan dalam melayani masyarakat. 2) Masyarakat dapat menerima masukan ataupun bantuan yang diberikan oleh pihak tim pelaksana dan pemerinta desa. 3) Tim dapat berperan dalam menjalin komunikasi yang baik dengan masyarakat sehingga kenyamanan masyarakat dapat terjamin. 4) tim mendapatkan pengalaman dan pelajaran tentang bagaimana cara berkomunikasi dengan masyarakat secara baik dan sopan. 5) Tanaman bisa dimanfaatkan oleh masyarakat menjadi bahan obat-obatan dalam kehidupan sehari -hari. 6) Mampu menambah wawasan mengurangi efek globalisasi, memperindah perkarangan. 7) Menyejukan halaman sekitar di musim panas membuat suasana sejuk dan alami. 8) Meningkatkan pengetahuan Masyarakat dalam penanaman yang baik dan jenis-jenis media yang cocok untuk tanaman. 9) Selain itu dalam kegiatan ini Masyarakat dapet mengenal jenis-jenis tanaman obat disekitar mereka yang lebih berguna bagi kehidupan sehari-hari.
Osthole in Bushen Formula May Block HBV Gene Expression throughNotch and NF-κB Pathways
Authors: Sun Mengqiu
Published: August 2023

Osthole is a natural coumarin in the Bushen formulation. Previous studies reported that it has the potential todownregulate Notch and NFκB, which are important signaling pathways in cells. Therefore, we predicted that ostiolemight affect HBV gene expression by down-regulating these two signaling pathways. This study provides experimentalprotocols to apply osthole to mouse hepatocytes and detect the strength of Notch and NFκB signaling pathways inthe cells and HBV gene expression levels. In this work, all possible results were analyzed. Notch signal intensity wasmeasured by assaying NICD, IκB measured NFκB signal intensity, and RT-PCR measured HBV gene expression level.The study of Osthole is meaningful for the research on Chinese medicine. This study will allow a better explanation ofthe mechanism of Bush’s formula and explore the more generalized effects of herbal medicines
Application of Speech Recognition in English PronunciationCorrection
Authors: Zhang Kaibo
Published: August 2023

In the context of economic globalization, countries are beginning to conduct ordinary trade transactions, so English, asthe most frequently used language, has been incorporated into the education system of each government and studentsare being taught English systematically, but the fastest way to improve English must be for a student to have a one-onone lesson with a native English speaker. However, with the world’s advanced educational resources, teaching Englishto students on a one-to-one basis is obviously not practical. Therefore, implanting a speech recognition system intoeducational software to help the software track or correct students’ English learning in real time is possible. However,replacing a real English teacher with the current speech recognition accuracy rate is still a challenge. Therefore, thispaper explains in detail how to improve speech recognition accuracy through lip motion tracking and MFCC and to givelearners the corresponding vocabulary ratings and suggestions for improvement through this model. In the long run, theknowledge tracking model is used to help students find the most suitable learning style.
Framing as a concept: a literature review on its development, andapplication with the example of content analysis
Authors: Wu Haotian
Published: August 2023

Despite its broad application in media communication and public management, Framing has been characterized astheoretically and empirically vague and has led to operational problems from the uncertainty of theoretical concepts. Inthis paper, I compare the definitions of the development process of farming chronically. I conclude with practical andprecise instances to illuminate the benefit of comprehending the media mentioned above effects fully. And the goal hereis to identify and make explicit explanations of the framing effect and to suggest a universal understanding of it and thebenefits of comprehending it more thoroughly.
Study on the evolution of silicon integrated circuit technology: fromscaling to lower power consumption
Authors: Wu Yiwen , Jia Ruofei , An Ziyang , Ding Baozhi
Published: August 2023

Silicon-integrated circuit technology has a profound influence on people’s daily lives. Throughout history, the goal ofthe evolution of this integrated technology has changed from scaling to lower power consumption because of multipledifficulties scientists face. By measuring and estimating the trade-off between circuit size and power, scientists havealready developed multiple new technologies to upgrade the silicon-integrated circuit. Some new methods people aretrying to find out that could be better to solve the problem. We did the research through one of the methods called postscaling technology. We found out it is possible to control the heat and power consumption of the circuit, which, underthe circumstance of minor scaling and stable operation mode.
Comparison on the effect of MART-10 and calcitriol on the treatmentof non-small cell lung cancer by determining which one is a morepotent drug in treating non-small cell lung cancer
Authors: Zou Xintong
Published: August 2023

Non-small cell lung cancer is one of the most common types of lung cancer, with a high mortality rate worldwide.The current treatment methods have apparent side effects and inevitable drawbacks. A compelling new drug is badlyin need of development. A previous study has reported that calcitriol and MART-10 can effectively block anaplasticthyroid cancer (ATC) spread. MART -10 is more potent than calcitriol in inhibiting migration and invasion of ATC.This study investigates the effect of NSCLC using MART-10 and calcitriol and finds out which is more potent, both invitro and in vivo. The experiments will use known human non-small cell lung cancer cell lines (A549 cell line) and twovitamin D compounds: MART-10 and calcitriol and Xenograft mouse system. MTT measures cell proliferation. FACSmeasures cell apoptosis for AnnexinV and PI. Measure development in tumor size by mouse xengraft system. A positivecontrol is taxol, and a negative control is PBS. There are three most possible results: (1) MART-10 and calcitriol cankill A549 lung cancer cells, and MART-10 reduce the number of A549 lung cancer cells at a lower concentration thanwith calcitriol. (2) MART-10 and calcitriol can kill A549 lung cancer cells, and calcitriol reduces the number of A549lung cancer cells at a lower concentration than with MART-10. (3) MART-10 and calcitriol do not significantly killA549 lung cancer cells. The result of the study will provide critical information for the future clinical trial of MART10 and calcitriol in treating NSCLC. It would increase our understanding of the more effective treatment of NSCLC andimprove human health. Future studies should focus on combinations of MART-10 or calcitriol with various anti-cancerchemotherapy drugs.
Treatment for ASD patients with the cadherin and catenin complexes
Authors: Han Yujia
Published: August 2023

The cadherin and catenin complexes are responsible for refinements and proper neural circuit formation during thecritical period. Abnormal refinement causes deficiencies in spine pruning and neuronal disorders, including autismspectrum disorder. Autism spectrum disorder (ASD) is a developmental disorder caused by defects in the spinecompetition. An increase in the cadherin and catenin complex can simulate the synaptic signal transmission and increasecompetition to maintain average spine density. However, the proper neuronal function requires the elimination ofunnecessary spines. Therefore, this paper designs an experiment using an ocular dominance column in mice to evaluatewhether the cadherin and catenin complex can overcome the deficiencies in spine pruning for ASD mice and whetherspine pruning is correct. Then, the cadherin and catenin complex is adopted on PFC in mice to evaluate the effect ofcorrection on social behavior for ASD mice. This work proposes a better treatment for ASD patients using the cadherinand catenin complex
The brief introduction and extension to Retrosynthesis
Authors: Zou Jiachun , Lin Jingqi , He Sutong , Zou Hanfei
Published: August 2023

Retrosynthesis is a vital methodology to design a complex molecule through the opposite direction, which is the opposite direction: breaking bonds. Many principles need to follow the rules. This study aims to summarize the rudimentary basis of retrosynthesis and give some outlook on the chemical synthesis of important molecules with important utilization value.
The Role and Application of Social Emotion in University Ideologicaland Political Education
Authors: Bai Qihua
Published: August 2023

In this study, we delve into the role and application of social emotions in university ideological and political education.We recognize social emotions, collective emotional experiences shared among individuals in a society, as essential inshaping students’ views. The exploration focuses on how educators can strategically use these emotions to encouragecivic consciousness, ethical behavior, and social responsibility. Our analysis indicates that incorporating social emotionsinto the curriculum amplifies the effectiveness of ideological education, cultivating empathy, solidarity, and activeparticipation in societal issues among students.
The effect of graphydine oxide (GDYO) nanosheets on disrupting theF-actin filament of anaplastic thyroid carcinoma (ATC) cells
Authors: ZhaoVictor  , Cheng Shu
Published: August 2023

Anaplastic thyroid carcinoma is deadly cancer with high mortality rates. Previous studies have shown that MART-10, ananalog to vitamin D, effectively prevents cancer’s metastatic potential by downregulating N-cadherin and filamentousactin filaments (F-action filament). In more recent studies around AML (acute myeloid leukemia), a novel materialname graphene oxide nanosheets (GDYO) are effective against AML related to DNA(cytosine-5)methyltransferase3A(DNMT3A)-mutated genes. It has also been found that GDYO nanosheets have been able to disrupt the F-actinfilament of AML cells, inducing cell apoptosis which leads to the destruction of the mutated cells. This paper exploresthe further application of this material in the biomedical field by testing the ability of GDYO nanosheets to inducecell apoptosis in other types of cancer, for example, ATC cells. The study will use an 8505C cell line with negativephosphate-buffered saline (PBS) and positive control Nexavar, a clinically tested drug that treats early ATC cell growth.Nexavar, also known as Sorafenib, inhibits tumor growth by a dual mechanism, acting directly on the tumor (throughinhibition of Raf and Kit signaling) and tumor angiogenesis (through inhibition of VEGFR and PDGFR signaling).The paper investigates whether GDYO can successfully disrupt the F-actin filaments of ATC cells, thereby killing themthrough inducing apoptosis and preventing the metastatic potential of ATC cells.
The role of SEVs in the promoting and treating liver fibrosis-MASP-1-enriched SEVs promote liver fibrosis while MSCs’ SEVs treating it
Authors: Guo Xiaoquan
Published: August 2023

Liver fibrosis is a chronic severe liver disease. One prominent feature of liver fibrosis is the activated Hepatic stellatecell. Across all the therapeutic tools for liver fibrosis, Mesenchymal stromal cells are widely studied and used. TheMSCs treat liver fibrosis by secreting cargo. One is an extracellular vesicle called an exosome containing proteins andother secrets. As the critical role of exosomes in the cell’s communication and interchange of substances, more researchis reported. Five types of exosomes from different sources that each have different roles in either promoting or inhibitingliver fibrosis are reviewed.
The role of G-proteins and G-protein-coupledreceptors in human disease
Authors: Xian YunCheng
Published: August 2023

In human diseases associated with G protein, changes in abnormal content and distribution of multiple signalingmolecules and abnormal signaling pathways play critical roles in pathophysiological pathways. Abnormal informationtransmission and signaling pathways are common channels in the pathogenesis of G protein diseases. G protein-coupledreceptors (GPCRs) are the largest group of membrane receptor proteins and represent the most common therapeutictargets for drugs. This paper uses liver injury, blood pressure regulation, Parkinson’s disease, and some cancers toillustrate the pathogenic mechanism and pathway-related treatment of G-protein and GPCR.
An analysis of the effect of Oxaliplatin in inducing immunogenetic celldeath and improving the efficacy of checkpoint inhibitor on SGC-7901
Authors: Wang Zhongxin
Published: August 2023

Previous studies demonstrated Oxaliplatin, a derivative of Cisplatin, to have anti-cancer properties in a Lewis LungCarcinoma (LLC). It can induce immunogenic cell death (ICD) in tumor cells and co-administrate with checkpointinhibitors to improve the therapeutic efficacy. This study aims to investigate Oxaliplatin’s effect on a different gastriccarcinoma, SGC-7901, and analyze the therapeutic efficacy of its co-administration with the checkpoint inhibitor. Toevaluate the immunogenic cell death (ICD) induced by Oxaliplatin in SGC-7901, flow cytometry, HMGB1, ATP release,and immunoblotting were conducted. The effectiveness of Oxaliplatin was analyzed using a vaccination approach andsubcutaneous tumor models to observe tumour regression. PD-L1 mRNA and protein levels in SGC-7901 were alsoexamined. The therapeutic efficacy of Oxaliplatin in murine lung tumor models will be enhanced by co-administeringwith aPD-L1. Cisplatin will be employed as a positive control, while PBS will be a negative control. The result of thestudy will provide important insight into the experimental effectiveness of Oxaliplatin in SGC-7901, it also sets thebasis for future experimental, preclinical, and clinical studies of the drug. Future studies should focus on practicing theactual experiment on the experimental effectiveness of Oxaliplatin in SGC-7901 and look for the applicability of theeffectiveness of Oxaliplatin on other tumor cells.
Methods to Improve Alcohol Fermentation Process: A Review
Authors: Zhang Jiarong , Shen Qifeng
Published: August 2023

Biofuel has been a hot research topic in the 21st century because it is promising to gradually replace today’s traditionalfuel in the future, which can protect the earth from many aspects. For example, biofuel’s biodegradability can reducepollution and solve the problem of the energy crisis to a certain extent. This paper mainly takes ethanol fuel as theresearch object focuses on the mechanism of yeast production of biofuel, different production methods, and benefits ofyeast, and discusses the future of isobutanol, a more efficient biofuel with more significant potential.
Bruceine F in Brucea Javanica Regulates Cellular STK3 and CK2A2 Targets to Correct Huntington Protein Misfolding in Mammalian Huntington’s Disease
Authors: Li Yiwen
Published: August 2023

Huntington’s disease is an autosomal dominant disorder characterized by progressive central nervous system degeneration characterized by motor, cognitive, and psychiatric disorders. This disease occurs frequently and is not easy to cure. We set out to investigate the pathogenesis of The Hippo pathway mediated by Brucea javanica in Huntington’s disease (HD) by studying the critical role of Brucea javanica in the pathogenesis of Huntington’s disease (HD) to provide a basis for the study of targeted drugs for this disease. Methods: Western blotting was used to rapidly determine YAP/TAZ activity and the expression level of HSF1 in tissues. YAP/TAZ activity and the expression level of HSF1 in tissues will show us the correct transcription level in the nucleus to measure efficacy. Hypothesis: Bruceine F in Brucea Javanica could effectively act on STK3 and CK2A2 targets to increase nuclear YAP activity and HSF1 expression, thus effectively treating Huntington’s disease. Possible Results: 1: Bruceine F does not act effectively on SYK3 and CK2A2 sites. There were no significant changes in YAP activity in either the nucleus or cytoplasm, as well as in STK3 and CK2A2 for all samples,the expression of HSF1 in tissues also did not change significantly. 2: Bruceine F successfully inhibited STK3, but activated CK2A2, and YAP activity was decreased in the cytoplasm and elevated in the nucleus. , HSF1 expression levels were decreased. 3:Bruceine F activated STK3 but inhibited CK2A2, and YAP activity was elevated in the cytoplasm and decreased in the nucleus. , HSF1 expression levels were elevated. 4: Bruceine F activated STK3 and CK2A2, and YAP activity was elevated in the cytoplasm and decreased in the nucleus. , HSF1 expression levels were reduced. 5:Bruceine F inhibited STK3 and CK2A2, YAP activity was decreased in the cytoplasm and increased in the nucleus, and HSF1 expression levels were increased. 6:Bruceine F activated CK2A2 in knockout STK3 mice, and YAP activity was unchanged in the cytoplasmic nucleus with reduced HSF1 expression. 7: Bruceine F inhibited CK2A2 in knockout STK3 mice, YAP activity was unchanged in the cytoplasmic nucleus, and HSF1 expression levels were elevated. 8: Bruceine F inhibited STK3 in knockout CK2A2 mice, and YAP activity was reduced in the cytoplasm and increased in the nucleus, while HSF1 expression levels remained unchanged. 9: Bruceine F activated STK3 in knockout CK2A2 mice, and YAP activity was increased in the cytoplasm and decreased in the nucleus, while HSF1 expression levels remained unchanged.
The Impacts of Epidemics on Green innovation: An Empirical Analysis
Authors: Li Wentai , Cong Yongqi , Xu Jiyao
Published: August 2023

This study investigates the impact of three types of epidemics on green innovation output using interaction terms and asystem of simultaneous equations, using data from around the world from 2010 to 2019 in 66 countries. Our empiricalevidence confirms that epidemic intensity is a key factor influencing green innovation and hindering internationaltechnology spillovers through international and regional R&D investment. Finally, we discuss the policy implications ofour results.
How Does Sleep Affect Emotional Status in Adolescence
Authors: He Xiaodan
Published: August 2023

Adolescence is a vital developmental phase characterized by substantial transformations in the physical, cognitive, emotional, and social domains of teenagers. Sleep is crucial for maintaining the mental stability of teenagers; nevertheless, contemporary lifestyle conditions, scholastic expectations, and the use of electronic gadgets are increasingly hindering adolescents’ capacity to obtain sufficient nighttime rest. This literature review seeks to consolidate existing studies on the correlation between sleep and emotional well-being in adolescents and propose additional recommendations on the subject.
The Effect of Anatoxin-a on Mice’s Body Systems During FHABs
Authors: Huang Shanshan
Published: August 2023

Currently, freshwater resources are a threat by the freshwater harmful algal blooms(FHABs) and human impact. Among the effects of FHABs, the harmful caused by cyanobacteria. The cyanobacteria are very obvious because they can produce cyanotoxin (dermatoxins, hepatotoxins, and neurotoxins) and anatoxin-a. It is most likely to cause death in humans and animals. Also, anatoxin-a has been implicated in animal mortality and can cause death in minutes. As a result, it is essential to research anatoxin-a, one of the neurotoxins, from three distinct aspects: mode of action and chronic or sublethal effects.
Anti-tumor Efficacy and Safety of the BAG3/HSP70 Inhibitor YM-1 ina Triple Negative Breast Cancer Model
Authors: Guo David Rui-jing
Published: August 2023

Patients who treat with TNBC are usually with intense chemotherapy. Recently, BAG3 has been suggested as apotential therapeutic target for cancer. However, inhibiting BAG3 for therapy may result in unintended damage tocardiomyocytes. Thus, this research proposal will test whether or not the inhibition of BAG3 will significantly affectthe heart while still having potent anti-tumor efficacy. Human TNBC cell line BT-549 cells will be inoculated into CB17/SCID mice. When the tumor grows to 100 mm3, mice will be intraperitoneally injected with different doses of YM1, an inhibitor of BAG3/HSP70. The clinically used TNBC chemotherapy drug doxorubicin will be used as the positivecontrol. The tumor growth, expressed as the change in tumor volume and tumor growth inhibition percentage (TGI),will be measured. Troponin I level in the serum, ECG measurement, and Hematoxylin and Eosin staining will be used toassess heart damage. The results of our study will indicate whether the animals will tolerate the BAG3 inhibitor, YM-1,at its effective doses and whether inhibition of BAG3 may be a better option, particularly regarding unwanted effects oncardiomyopathy, compared to standard of care in TNBC. Future investigations are warranted.
The effect of Oxaliplatin in leading to apoptosis of intestinal cancer cells byinducing PUMA protein expression through reactive oxygen species
Authors: Gao Jiayi
Published: August 2023

Previous studies demonstrated Oxaliplatin, a drug used in treating intestinal cancers by inducing cancer cell apoptosisregulated by p53 upregulated modulator of apoptosis (PUMA) protein gene expression. Increasing the reactiveoxygen species (ROS) level is possible to speed up the expression of PUMA protein in Oxaliplatin. This study aimsto investigate the effect of Oxaliplatin in intestinal cancer cells, leading to its apoptosis by inducing PUMA proteinexpression through ROS, compared to Cisplatin and PBS. The result of the study will provide important insight into thepreclinical effectiveness of Oxaliplatin in intestinal cancer cells, and it also testifies to the underlying mechanism of thisdrug. Future studies should focus on investigating drug combinations with Oxaliplatin that provides synergism towardthe disease and decreases its toxicity.
Effect of PP2A concentration on the carcinogenicity of MCs
Authors: Bai Andrew K
Published: August 2023

Microcystins (MCs) are normal FHAB toxins that are harmful to humans. The toxicological mechanism of MCs is to form covalent bonds with serine protein phosphatases and disrupt the phosphorylation process of cells. Which leads to hyperphosphorylation, which leads to tumor formation. This study tries to study whether keep the process of phosphorylation of cells by increasing the PP2A concentration. Method The experiment will use the animal model, Western blot test for Akt activation, Thr308 and Ser473 within Akt, and PP2A activated acid test.
The Importance of the Absence of Interpretation in the Museum Context in Promoting Children’s Participation in the Meaning-Making of Artworks
Authors: Qian Yuxi
Published: August 2023

From its inception, the discipline of art history has involved developing and applying modes of interpretation to derive meaning from works of art. Art museums represent an institutionalized model of interpretation. Specialist guides and exhibition catalogs all represent ways of interpreting and understanding the meaning of works of art. However, based on a constructivist system of knowledge, such interpretations create preconceptions about the meaning of the work. It does not contribute to the diversity of its expression. For school-age children at the peak of their creativity, an overemphasis on the presence of interpretation removes their motivation to interpret on their own, making them become replicators rather than producers of the meaning of their work. At the same time, their contribution to the meaning of the work that their unique way of intuitively responding to it is ignored. This paper will, therefore, first argue for the importance of children in the multiple productions of meaning in works of art. It will then build on Davis and Gardner’s “Three-Window Approach” to show how the absence of expert discourse in museums (referred to as the absence of interpretation) facilitates the participation of schoolchildren in the meaning-making of works of art.
Research on the willingness of Chinese mobile payment APP users to continue to use from the perspective of status quo bias
Authors: Li Bojiong
Published: August 2023

Based on the status quo bias, explore the impact of brand attachment on the continuous use of mobile payment platform users. Introducing the S-O-R model, which takes sunk costs and conversion costs as stimuli, ultimately affecting users’ willingness to continue using through brand attachment. Conduct a questionnaire survey and conduct empirical analysis. Finally, it was found that sunk costs and conversion costs positively affect brand attachment, and brand attachment positively affects user willingness to use
New Approaches for the Synthesis of Cleistanthol
Authors: Wu Yichun , Huang Xiaoyu
Published: August 2023

An article published on 15 April 2022 isolated cleistanthol from Sauropus spatulifolius. This report will present one of the first few new approaches for synthesizing cleistanthol and how the approach is derived by retrosynthetic analysis, along with discussions on the weaknesses of this approach and suggestions for possible improvements. Sauropus spatulifolius, often used in traditional Chinese medicine, is expected to play a role in treating some diseases of the respiratory system. To make the medicine more efficient and targeted, this work is committed to excogitate a convenient approach to synthesize an abstract of sauropus spatulifolius, cleistanthol, in high yield. The approach takes stereostructure into account so as to be utilized in pharmacy.
APPLICATION OF THE MARKOWITZ MODEL AND INDEXMODEL IN REAL STOCK MARKETS
Authors: Yao Lexi
Published: August 2023

The complete Markowitz Model and the Index Model have a wide range of applications for portfolios in the stockmarket, and in this paper, we want to apply these two models in a realistic stock market. In this paper, ten stocksbelonging to different industries and the S&P 500 equity index are selected as a portfolio, and the 1-month Fed Fundsrate is chosen as the risk-free rate. Through proper data aggregation and processing, we calculate the weights ofeach stock in the portfolio in the case of minimal portfolio variance and maximal Sharpe ratio under five additionalconstraints using the complete Markowitz Model and the Index Model, respectively. Finally, we can calculate theminimal variance frontier, efficient frontier, inefficient frontier, and capital allocation line under each constraint, plottedusing the Solver Table in Excel
KO MAT2A to further inhibit hypomorphic PRMT5 in MATPdeficient TNBC cells for metastasis suppression in vitro and in vivo
Authors: Chen Jiajie
Published: August 2023

Triple-negative breast cancer is one of the common types with the lack of three joint receptors, ER, PR, and HER2, which leads to inadequate responses for current breast cancer targeting therapy. Previous studies have reported that MTAP deletion confers enhanced sensitivity for PRMT5 inhibition, and inhibition of PRMT5 suppresses cell growth by decreasing arginine methylation of eIF4E and FGFR3. The KO of MAT2A will reduce the level of SAM, which is the substrate for arginine methylation, to inhibit PRMT5 and reduce cell proliferation. This study investigates the comparison of effects for MAT2A KO in MATP-deficient and MTAP+/+ TNBC cells in vivo and in vitro..