bluuebunny/crossref_metadata_2025 huggingface dataset:
Short-term antidepressant treatment has long-lasting effects, and reverses stress-induced decreases in bone features in rats
Authors: Lee S. H. , Mastronardi C. A. , Li R. W. , Paz-Filho G. , Dutcher E. G. , Lewis M. D. , Vincent A. D. , Smith P. N. , Bornstein S. R. , Licinio J. , Wong M. L.
Published: January 2019

Antidepressants are among the most-prescribed class of drugs in the world and though weight gain is a common outcome of antidepressant treatment, that effect is not well understood. We employed an animal model comprised of 2 weeks of chronic restraint stress with antidepressant treatment, followed by diet-induced obesity. We showed that short-term antidepressant treatment had long-lasting effects, not only leading to weight gain, but also enhancing trabecular and cortical bone features in rats; therefore, weight gain in this model was different from that of the classic diet-induced obesity. Late in the post-restraint recovery period, antidepressant-treated animals were significantly heavier and had better bone features than saline-treated controls, when assessed in the distal femoral metaphysis. The propensity to gain weight might have influenced the rate of catch-up growth and bone allometry, as heavier animals treated with fluoxetine also had enhanced bone features when compared to non-stressed animals. Therefore, short-term antidepressant treatment ameliorated the long-term effects of stress on body growth and bone. Growth and bone structural features were associated with leptin levels, and the interaction between leptin levels and antidepressant was significant for bone mineral content, suggesting that short-term antidepressants in the context of long-term diet-induced obesity modified the role of leptin in bone formation. To our knowledge this is the first study reporting that short-term antidepressant treatment has long-lasting effects in restoring the effects of chronic stress in body weight and bone formation. Our findings may be relevant to the understanding and treatment of osteoporosis, a condition of increasing prevalence due to the aging population.
(Epi)genetic defects of MKRN3 are rare in Asian patients with central precocious puberty
Authors: Suzuki Erina , Shima Hirohito , Kagami Masayo , Soneda Shun , Tanaka Toshiaki , Yatsuga Shuichi , Nishioka Junko , Oto Yuji , Kamiya Toshiya , Naiki Yasuhiro , Ogata Tsutomu , Fujisawa Yasuko , Nakamura Akie , Kawashima Sayaka , Morikawa Shuntaro , Horikawa Reiko , Sano Shinichiro , Fukami Maki
Published: January 2019

We sequenced MKRN3, the major causative gene of central precocious puberty in Western countries, in 24 Japanese or Chinese patients and examined the DNA methylation and copy-number statuses of this gene in 19 patients. We identified no (epi)genetic defects except for one previously reported mutation. These results, together with reports from Korea, indicate that MKRN3 defects are rare in Asian populations. The ethnic differences likely reflect Western country-specific founder mutations and the rarity of de novo mutations.
SnRK2 protein kinases represent an ancient system in plants for adaptation to a terrestrial environment
Authors: Shinozawa Akihisa , Otake Ryoko , Takezawa Daisuke , Umezawa Taishi , Komatsu Kenji , Tanaka Keisuke , Amagai Anna , Ishikawa Shinnosuke , Hara Yurie , Kamisugi Yasuko , Cuming Andrew C. , Hori Koichi , Ohta Hiroyuki , Takahashi Fuminori , Shinozaki Kazuo , Hayashi Takahisa , Taji Teruaki , Sakata Yoichi
Published: January 2019

The SNF1-related protein kinase 2 (SnRK2) family includes key regulators of osmostress and abscisic acid (ABA) responses in angiosperms and can be classified into three subclasses. Subclass III SnRK2s act in the ABA response while ABA-nonresponsive subclass I SnRK2s are regulated through osmostress. Here we report that an ancient subclass III SnRK2-based signalling module including ABA and an upstream Raf-like kinase (ARK) exclusively protects the moss Physcomitrella patens from drought. Subclass III SnRK2s from both Arabidopsis and from the semiterrestrial alga Klebsormidium nitens, which contains all the components of ABA signalling except ABA receptors, complement Physcomitrella snrk2− mutants, whereas Arabidopsis subclass I SnRK2 cannot. We propose that the earliest land plants developed the ABA/ARK/subclass III SnRK2 signalling module by recruiting ABA to regulate a pre-existing dehydration response and that subsequently a novel subclass I SnRK2 system evolved in vascular plants conferring osmostress protection independently from the ancient system.
The Cdc48 unfoldase prepares well-folded protein substrates for degradation by the 26S proteasome
Authors: Olszewski Michal M. , Williams Cameron , Dong Ken C. , Martin Andreas
Published: January 2019

Cdc48/p97 is an essential and highly conserved AAA+ ATPase that uses its protein-unfoldase activity to extract ubiquitinated polypeptides from macromolecular complexes and membranes. This motor has also been implicated in protein-degradation pathways, yet its exact role in acting upstream of the 26S proteasome remains elusive. Ubiquitinated proteins destined for degradation by the proteasome require an unstructured initiation region to engage with the proteasomal translocation machinery, and Cdc48 was proposed to generate these unfolded segments, yet direct evidence has been missing. Here, we used an in vitro reconstituted system to demonstrate the collaboration of Cdc48 and the 26S proteasome from S. cerevisiae in degrading ubiquitinated, well-folded proteins that lack unstructured segments. Our data indicate that a critical role for Cdc48 in the ubiquitin-proteasome system is to create flexible initiation regions in compact substrates that otherwise would be refractory to engagement and degradation by the proteasome.
Phosphoric acid and phosphorylation levels are potential biomarkers indicating developmental competence of matured oocytes
Authors: Ishigaki Mika , Hoshino Yumi , Ozaki Yukihiro
Published: January 2019

We identified biomarkers for mice oocyte maturation in metaphase IIin vivoandin situusing Raman spectroscopy.
Biologically-active unilamellar vesicles from red blood cells
Authors: Jang Hyun-Sook , Cho Yoon-Kyoung , Granick Steve
Published: January 2019

Methods are described to prepare biologically-active unilamellar vesicles from red blood cells. Whereas glucose enters the GUV causing fluorescence intensity to increase, mediated by the action of the membrane protein GLUT1, control experiments confirm that this fails to be observed in the presence of the blocking agent cytochalasin B.
Preparation of a one-dimensional nanorod/metal organic framework Janus nanoplatform via side-specific growth for synergistic cancer therapy
Authors: Zhang Haipeng , Zhang Qin , Liu Chunshui , Han Bing
Published: January 2019

A unique LA-AuNR/ZIF-8 Janus nanoparticle is firstly prepared by side-specific growth of ZIF-8 on one-dimensional AuNR for drug loading to realize the CT image-guided active targeted synergistic chemo-photothermal cancer therapy.
Photo-induced formation of organic nanoparticles possessing enhanced affinities for complexing nerve agent mimics
Authors: Border Sarah E. , Pavlović Radoslav Z. , Zhiquan Lei , Gunther Michael J. , Wang Han , Cui Honggang , Badjić Jovica D.
Published: January 2019

Organic nanoparticles, composed of molecular baskets, could act as nanocarriers for selective “mopping” of toxic CWAs or pesticides, after being assembled by a light stimulus.
Multi-colour uranyl emission efficiently tuned by hexacyanidometallates within hybrid coordination frameworks
Authors: Chorazy Szymon , Zakrzewski Jakub J. , Reczyński Mateusz , Sieklucka Barbara
Published: January 2019

Hexacyanidometallates of transition metal ions govern the topology and the photoluminescence of bimetallic d–f hybrid coordination networks incorporating uranyl cations.
Chemically fueled covalent crosslinking of polymer materials
Authors: Zhang Borui , Jayalath Isuru M. , Ke Jun , Sparks Jessica L. , Hartley C. Scott , Konkolewicz Dominik
Published: January 2019

Non-equilibrium covalently crosslinked hydrogels are synthesized using carbodiimide fueled coupling of carboxylic acids to anhydrides which eventually dissipate by hydrolysis.
A duplex connection can further illuminate G-quadruplex/crystal violet complex
Authors: Wang Shuang , Zhao Jiahui , Lu Shasha , Sun Jian , Yang Xiurong
Published: January 2019

A duplex connection can distinctly enhance the fluorescence of G-quadruplex/crystal violet, which also was used in target DNA detection.
The first atomic layer deposition process for FexN films
Authors: Du Liyong , Huang Wei , Zhang Yuxiang , Liu Xinfang , Ding Yuqiang
Published: January 2019

An efficient process for ALD FexN films was reported in this study for the first time.
A stoichiometric CdS interlayer for the photovoltaic performance enhancement of quantum-dot sensitized solar cells
Authors: Chen Shixin , Wang Yinglin , Lu Shuang , Liu Yichun , Zhang Xintong
Published: January 2019

We employed a sol–gel method to prepare a CdS interlayer (CdS-SG) with a stoichiometric ratio and then fabricated QDSCs.
Isotope effect on hydrogen bond symmetrization in hydrogen and deuterium fluoride crystals by molecular dynamics simulation
Authors: Dammak Hichem , Brieuc Fabien , Geneste Grégory , Torrent Marc , Hayoun Marc
Published: January 2019

We evidence the symmetrization of the H-bonds occurring in HF and the deuteron hopping in DF through the tunnel effect.
Reply to the ‘Comment on “Spectroscopic properties and location of the Ce3+ energy levels in Y3Al2Ga3O12 and Y3Ga5O12 at ambient and high hydrostatic pressure”’ by Y. Wang, M. Głowacki, M. Berkowski, A. Kamińska and A. Suchocki, Phys. Chem. Chem. Phys., 2019, 21, DOI: 10.1039/C8CP06154H
Authors: Mahlik Sebastian , Lazarowska Agata , Ueda Jumpei , Tanabe Setsuhisa , Grinberg Marek
Published: January 2019

In this reply we respond to recent comments of Wang et al.
Influence of fullerenol on hIAPP aggregation: amyloid inhibition and mechanistic aspects
Authors: Bai Cuiqin , Lin Dongdong , Mo Yuxiang , Lei Jiangtao , Sun Yunxiang , Xie Luogang , Yang Xinju , Wei Guanghong
Published: January 2019

C60(OH)24inhibits hIAPP aggregation by suppressing the fibril-prone structure and destabilizes hIAPP protofibrils by binding to the amyloid core region.
Reaction mechanism between small-sized Ce clusters and water molecules: an ab initio investigation on Cen + H2O
Authors: Zhou Rulong , Yang Yang , Pande Seema , Qu Bingyan , Li Dongdong , Zeng Xiao Cheng
Published: January 2019

Reactions of small-sized cerium clusters Cen (n = 1–3) with a single water molecule are systematically investigated theoretically. The ground state structures of the Cen/H2O complex and the reaction pathways between Cen + H2O are predicted.
Zn and Co redox active coordination polymers as efficient electrocatalysts
Authors: Shekurov Ruslan , Khrizanforova Vera , Gilmanova Leysan , Khrizanforov Mikhail , Miluykov Vasily , Kataeva Olga , Yamaleeva Zilya , Burganov Timur , Gerasimova Tatiana , Khamatgalimov Airat , Katsyuba Sergey , Kovalenko Valeri , Krupskaya Yulia , Kataev Vladislav , Büchner Bernd , Bon Volodymyr , Senkovska Irena , Kaskel Stefan , Gubaidullin Aidar , Sinyashin Oleg , Budnikova Yulia
Published: January 2019

New redox active 1D helical coordination polymers M(fcdHp) (M(ii) = Zn(1), Co(2)) have been obtained.
Oxidative addition of arsenic halides to platinum(0)
Authors: Muessig Jonas H. , Stennett Tom E. , Schmidt Uwe , Dewhurst Rian D. , Mailänder Lisa , Braunschweig Holger
Published: January 2019

AsCl3 and AsBr3 are shown to undergo oxidative addition to Pt(0) complexes. With AsCl3, a single As–Cl oxidative addition step selectively yields (chloro)(arsenido)-Pt(ii) complexes, whereas with AsBr3 both monomeric and cluster compounds are produced.
Energy efficient electrochemical reduction of CO2 to CO using a three-dimensional porphyrin/graphene hydrogel
Authors: Choi Jaecheol , Kim Jeonghun , Wagner Pawel , Gambhir Sanjeev , Jalili Rouhollah , Byun Seoungwoo , Sayyar Sepidar , Lee Yong Min , MacFarlane Douglas R. , Wallace Gordon G. , Officer David L.
Published: January 2019

A 3D iron porphyrin/graphene hydrogel electrocatalyst affords highly efficient, durable and selective CO2 reduction to CO at a low overpotential.
Comparison of the benzene sorption properties of metal organic frameworks: influence of the textural properties
Authors: Belarbi Hichem , Gonzales Philippe , Basta Altaf , Trens Philippe
Published: January 2019

CuBTC exhibits stronger interaction with benzene as compared to MIL-101. It should be preferred for benzene remediation.
Removal and recovery of Pb from wastewater through a reversible phase transformation process between nano-flower-like Mg(OH)2 and soluble Mg(HCO3)2
Authors: Liu Xueming , Song Kainan , Liu Weizhen , Xiong Yuecheng , Xu Yunyun , Shi Zhenqing , Zhao Dongye , Lin Zhang
Published: January 2019

This study investigated the effectiveness of a new technique for recovering Pb as highly pure PbCO3 nanoparticles from wastewater by using a nano-Mg(OH)2 adsorbent.
A framework to analyze sulfate versus chloride selectivity in nanofiltration
Authors: Roy Yagnaseni , Lienhard John H.
Published: January 2019

Interspecies selectivity between NaCl and Na2SO4 in nanofiltration is explained by a simple, intuitive analytical framework.
Application of novel solid phase extraction-NMR protocols for metabolic profiling of human urine
Authors: McGill Daniel , Chekmeneva Elena , Lindon John C. , Takats Zoltan , Nicholson Jeremy K.
Published: January 2019

Novel SPE-NMR methods were developed for selective retention of metabolites in human urine.
Rapid liquid biopsy for Mohs surgery: rare target cell separation from surgical margin lavage fluid with a high recovery rate and selectivity
Authors: Zhou Wenbo , Liu Yaoping , Ran Menglong , Zhao Xiaofan , Li Hang , Li Haichao , Wang Wei
Published: January 2019

A liquid biopsy was established for rapid and sensitive examination of residual tumor cells on surgical margin during Mohs surgery.
Impact resistance of nanocellulose films with bioinspired Bouligand microstructures
Authors: Qin Xin , Marchi Benjamin C. , Meng Zhaoxu , Keten Sinan
Published: January 2019

Low-pitch angle CNC films with Bouligand microstructures outperform traditional composite layups through improved energy dissipation capability.
Polyoxometalate@MIL-101/MoS2: a composite material based on the MIL-101 platform with enhanced performances
Authors: Liang Dadong , Liang Chen , Meng Lingkun , Lou Yue , Li Chunguang , Shi Zhan
Published: January 2019

MIL-101 was used as a platform to integrate two functional materials for achieving enhanced dye adsorption and separation performances.
Substrate-induced hydrothermal synthesis of hematite superstructures and their Fischer–Tropsch synthesis performance
Authors: Xue Yingying , Sun Jiaqiang , Abbas Mohamed , Chen Zheng , Wang Pengfei , Chen Yilong , Chen Jiangang
Published: January 2019

Fe foam substrates with different pore densities are used to fabricate versatile α-Fe2O3 nanostructures with different Fischer–Tropsch synthesis performance.
Synthesis and photophysical properties of conjugated (dodecyl)benzoateethynylene macromolecules: staining ofBacillus subtilisandEscherichia colirhizobacteria
Authors: Concepción García Ma. , Turlakov Gleb , Moggio Ivana , Arias Eduardo , Valenzuela J. Humberto , Hernández Mónica , Rodríguez Geraldina , Ziolo Ronald F.
Published: January 2019

The staining of agrobacteria was successfully demonstrated through a benzoateethynylene by fluorescence spectroscopy, laser confocal microscopy and microRaman.
A selective and sensitive peptide-based fluorescent chemical DSH sensor for detection of zinc ions and application in vitro and in vivo
Authors: Zhang Lili , Cao Jun , Chen Kai , Liu Yi , Ge Yushu , Wu Jiang , Liu Dan
Published: January 2019

Here we report the design and synthesis of a peptide-based fluorescent chemical sensor (DSH sensor: Dansyl-Ser-Pro-Gly-His-Trp-Gly) for detecting Zn2+, based on fluorescence resonance energy transfer (FRET) from tryptophan (donor) to the dansyl fluorophore (acceptor).
Racemization of oxazepam and chiral 1,4-benzodiazepines. DFT study of the reaction mechanism in aqueous solution
Authors: Hok Lucija , Božičević Lucija , Sremec Helena , Šakić Davor , Vrček Valerije
Published: January 2019

The tranquilizer and hypnotic drug oxazepam undergoes the racemization process in aqueous medium, which is relevant for its pharmacological profile.
An imidazole derivative-based chemodosimeter for Zn2+ and Cu2+ ions through “ON–OFF–ON” switching with intracellular Zn2+ detection
Authors: Ansari Shagufi N. , Saini Anoop K. , Kumari Pratibha , Mobin Shaikh M.
Published: January 2019

Imidazole derivative-based chemodosimeter (HL) for selective detection of Zn2+ and Cu2+ metal ions and intracellular Zn2+ sensing.
Metal chelate induced in situ wrapping of Ni3S2 nanoparticles into N, S-codoped carbon networks for highly efficient sodium storage
Authors: Li Jiabao , Li Jinliang , Chen Taiqiang , Lu Ting , Mai Wenjie , Pan Likun
Published: January 2019

Metal-dithiooxamide chelate derived Ni3S2 nanoparticles wrapped in N, S codoped carbon networks exhibit excellent sodium storage performance.
Experimental study on viscosity reduction of heavy oil by hydrogen donors using a cavitating jet
Authors: Wan Chunhao , Wang Ruihe , Zhou Weidong , Li Luopeng
Published: January 2019

Cavitating jet technology is used to change the quality and to reduce the viscosity of heavy oil because bubble collapse can cause extreme conditions such as high pressure and temperature.
Goethite–titania composite: disinfection mechanism under UV and visible light
Authors: Lara-Rico Rosalina , Múzquiz-Ramos Elia M. , López-Badillo Claudia M. , García-Pérez Ulises M. , Cruz-Ortiz Brenda R.
Published: January 2019

A photocatalytic mechanism for FeOOH–TiO2 composite is proposed under UV-Vis light, the FeOOH–TiO2 composite showed higher photocatalytic activity than TiO2-P25.
High performance of PtCu@TiO2nanocatalysts toward methanol oxidation reaction: from synthesis to molecular picture insight
Authors: Dimitrova Nina , Dhifallah Marwa , Mineva Tzonka , Boiadjieva-Scherzer Tzvetanka , Guesmi Hazar , Georgieva Jenia
Published: January 2019

Computed adhesion energies of pure and bimetallic PtCu clusters (regular alloy, phase-separated, core–shell) on TiO2anatase support.
Magneto-EELS of armchair boronitrene nanoribbons
Authors: Le P. T. T. , Mirabbaszadeh K. , Yarmohammadi M.
Published: January 2019

The evolution of the electron energy loss spectrum (EELS) of ultranarrow armchair boron nitride nanoribbons (aBNNRs) during low and high photon energy transfers has been studied theoretically when a magnetic field and temperature gradient are applied.
Influence of alkalinity on the synthesis of hierarchical LTA zeolite by using bridged polysilsesquioxane
Authors: Hu Sufang , Song Guoqiang , Xue Da , Li Fuxiang
Published: January 2019

The mechanism of formation of hierarchical LTA zeolite involved the methoxyl groups of bridged polysilsesquioxane hydrolyzing into hydroxyl groups. The Si–O–Si bond was formed between silicon hydroxyl and silica by dehydration, avoiding phase separation.
Green synthesis of silver nanoparticles: biomolecule-nanoparticle organizations targeting antimicrobial activity
Authors: Roy Anupam , Bulut Onur , Some Sudip , Mandal Amit Kumar , Yilmaz M. Deniz
Published: January 2019

In this review, we discuss the recent advances in green synthesis of silver nanoparticles, their application as antimicrobial agents and mechanism of antimicrobial mode of action.
The role of sp2and sp3hybridized bonds on the structural, mechanical, and electronic properties in a hard BN framework
Authors: Bu Hongxia , Zheng Haibin , Zhou Hongcai , Zhang Hongyu , Yang Zaifa , Liu Zhie , Wang Hui , Xu Qi
Published: January 2019

A first-principles approach is used to systematically investigate the role of sp2and sp3hybridized bonds on the structural, mechanical, and electronic properties in a new BN phase (denoted Hex-(BN)12).
Diameter-definable tubing-microchips for applications in both continuous-flow and TEC-modulated on-chip qPCRs with reaction signal analyzed between different types of Teflon-polymers: PTFE and FEP
Authors: Jiang Yangyang , Wu Guizhu , Li Yuanming , Wu Wenming
Published: January 2019

For micro-continuous qPCRs, the FEP tube is superior to the PTFE tube in measuring the fluorescence single.
Computational fluid dynamics of DNA origami folding in microfluidics
Authors: Hua Tianyi , Hartman Ryan L.
Published: January 2019

A computational fluid dynamics study of single and multiphase microfluidics for understanding DNA origami folding kinetics in continuous-flow.
Charge transport and glassy dynamics in polymeric ionic liquids as reflected by their inter- and intramolecular interactions
Authors: Frenzel Falk , Borchert Pia , Anton Arthur Markus , Strehmel Veronika , Kremer Friedrich
Published: January 2019

Analysing inter- and intramolecular interactions of polymeric ionic liquids leads to the identification of charge transport responsive and irresponsive moieties.
Normal stress anisotropy and marginal stability in athermal elastic networks
Authors: Shivers Jordan L. , Feng Jingchen , Sharma Abhinav , MacKintosh F. C.
Published: January 2019

We investigate the influence of network structure on normal stresses in subisostatic, athermal elastic networks under applied shear strain.
Drug release from thin films encapsulated by a temperature-responsive hydrogel
Authors: Werzer Oliver , Tumphart Stephan , Keimel Roman , Christian Paul , Coclite Anna Maria
Published: January 2019

Temperature-controlled release and study on the effects of the drug–polymer interaction and pH.
Lone-pair effect on carrier capture in Cu2ZnSnS4solar cells
Authors: Kim Sunghyun , Park Ji-Sang , Hood Samantha N. , Walsh Aron
Published: January 2019

Fast electron–hole recombination in kesterite solar cells is linked to the chemistry of the Sn lone electron pair.
Optimal structuring of nitrogen-doped hybrid-dimensional nanocarbons for high-performance flexible solid-state supercapacitors
Authors: Cao Xianyi , Jia Shuai , Huang Wei , Tang Yingying , Duus Jens Øllgaard , Lou Jun , Chi Qijin
Published: January 2019

Nitrogen-doped hybrid-dimensional nanocarbons are architectured into special structures and used for fabrication of solid-state flexible supercapacitors showing high-performance energy storage capacity.
Highly effective fabrication of two dimensional metal oxides as high performance lithium storage anodes
Authors: Chen Zhi , Wang Cun , Chen Min , Ye Changchun , Lin Zeheng , Xing Lidan , Liao Youhao , Xu Mengqing , Cao Guozhong , Li Weishan
Published: January 2019

H2O/DMF solvent ratio-tuned MnO microflakes serve as high-performance lithium storage anodes, further improved by CNTs assisted-synthesis.
Linear-like lead-free relaxor antiferroelectric (Bi0.5Na0.5)TiO3–NaNbO3 with giant energy-storage density/efficiency and super stability against temperature and frequency
Authors: Qi He , Zuo Ruzhong
Published: January 2019

A novel lead-free polar dielectric ceramic with linear-like polarization responses was found in (1 − x)(Bi0.5Na0.5)TiO3–xNaNbO3 ((1 − x)BNT–xNN) solid solutions, exhibiting giant energy storage density/efficiency and super stability against temperature and frequency.
Outstanding cycle stability and rate capabilities of the all-solid-state Li–S battery with a Li7P3S11 glass-ceramic electrolyte and a core–shell S@BP2000 nanocomposite
Authors: Han Qigao , Li Xuelei , Shi Xixi , Zhang Hongzhou , Song Dawei , Ding Fei , Zhang Lianqi
Published: January 2019

A Li7P3S11 glass-ceramic solid electrolyte and a core–shell S@BP2000 nanocomposite are used to fabricate all-solidstate Li–S batteries, which exhibit outstanding cycle stability and rate capabilities.
Combining dietary phenolic antioxidants with polyvinylpyrrolidone: transparent biopolymer films based onp-coumaric acid for controlled release
Authors: Contardi Marco , Heredia-Guerrero José A. , Guzman-Puyol Susana , Summa Maria , Benítez José J. , Goldoni Luca , Caputo Gianvito , Cusimano Giovanni , Picone Pasquale , Di Carlo Marta , Bertorelli Rosalia , Athanassiou Athanassia , Bayer Ilker S.
Published: January 2019

Polyvinylpyrrolidone polymer was transformed into a controlled release films with a natural antioxidant.
A dual-inhibitor system for the effective antifibrillation of Aβ40 peptides by biodegradable EGCG–Fe(iii)/PVP nanoparticles
Authors: Liu Zexiu , Li Xianglong , Wu Xiaoping , Zhu Chunling
Published: January 2019

By the synergistic effect of dual inhibition, EFPP NPs exhibited a significant effect on the inhibition of Aβ40 fibrillation and on the disaggregation of existing Aβ40 fibrils.
Two spirobifluorene-based fluorescent probes with aggregation-induced emission properties: synthesis and application in the detection of Zn2+ and cell imaging
Authors: Wan Jianyong , Zhang Wu , Guo Hongda , Liang JingJing , Huang Danyu , Xiao Haibo
Published: January 2019

The synthesis and application of two spirobifluorene-based probes with AIEE properties have been reported for the first time.
Novel Na2TiSiO5 anode material for lithium ion batteries
Authors: He Di , Wu Tianhao , Wang Boya , Yang Yubo , Zhao Shu , Wang Jinshu , Yu Haijun
Published: January 2019

Na2TiSiO5 is investigated and applied in a lithium battery, with its low potential and high capacity revealing its potential use as an alternative to graphite.
Editorial Perspectives: the value proposition of resource recovery
Authors: Jason Ren Zhiyong
Published: January 2019

Zhiyong Jason Ren provides the first in a series of ‘Editorial Perspectives’ for Environmental Science: Water Research & Technology.
Extrakorporale Membranoxygenierung in der Thoraxchirurgie: Etablierung funktioneller und technischer Operabilität
Authors: Akil Ali , Bölükbas Servet , Wiebe Karsten
Published: January 2019

Funktionelle und technische Operabilität müssen vor thoraxchirurgischen Eingriffen evaluiert und definiert werden. Nicht selten gelten Patienten aufgrund funktioneller Einschränkung und/oder aufgrund einer ungünstigen Lokalisation des Tumors als inoperabel. Die extrakorporale Lungenunterstützung stellt in der Thoraxchirurgie ein wichtiges Verfahren zur Etablierung funktioneller und technischer Operabilität dar. Sie ermöglicht eine perioperative Sicherheit und minimiert das Risiko während anspruchsvoller Resektionen.
Analyse der Kodierungsqualität der Leichenschauscheine und
Obduktionsraten in Chemnitz, 2010–2013
Authors: Illing Georg , Lessig Rüdiger , Stang Andreas
Published: January 2019

Hintergrund Die Leichenschau als der letzte Dienst des Arztes am
Patienten ist in den letzten Jahren zunehmend in die Kritik geraten. Das Ziel
dieser Arbeit ist es anhand der Daten aus Chemnitz zu untersuchen, welchen
Einfluss der Sterbeort, der leichenschauende Arzt, das Alter und Geschlecht der
Verstorbenen auf die Kodierungsvollständigkeit und
Kodierungsqualität der Todesursachen in den Todesbescheinigungen
hat.

Methoden Es wurden insgesamt 15 612 Todesbescheinigungen und 353
Obduktionsscheine des Gesundheitsamts Chemnitz aus den Sterbebuchjahren
2010–2013 ausgewertet. Es wurden die Merkmale Alter, Geschlecht,
Todesursache nach Erstleichenschau sowie nach evtl. erfolgter Obduktion,
Todesart und eventuelle Komplikationen im Rahmen der zweiten Leichenschau
erfasst. Zusätzlich wurde die Sterbeort- und Leichenschauarzt-Kategorie
erhoben. Außerdem wurden mangelhaft oder falsch kodierte
Todesbescheinigungen berichtigt und eine Übereinstimmungsanalyse
durchgeführt. Die Auswertung erfolgte hierbei gemäß den
formalen Kriterien des Deutschen Instituts für Medizinische
Dokumentation und Information für das grundsätzliche
Ausfüllen von Todesbescheinigungen.

Ergebnisse Die Obduktionsrate betrug 2,3%. Das Grundleiden wurde
in 34,1% nicht dokumentiert. Die Übereinstimmung zwischen
qualitätsgesicherter Nachkodierung und der primären 3-stelligen
ICD-10 Kodierung war hoch (96,5%). Hohes Alter und Sterben
außerhalb des Krankenhauses sowie die Durchführung der
Leichenschau durch einen Arzt, der nicht im Krankenhaus die Leichenschau
durchführt, waren mit einer höheren Wahrscheinlichkeit einer
ICD-10 Fehlkodierung assoziiert. Die beobachtete Übereinstimmung des
3-stelligen ICD-10 kodierten Grundleidens des Leichenschauscheins und
Obduktionsscheins betrug 26,3%. In 24,2% enthielt das
Grundleiden sogenannte Garbage Codes, die für eine
Todesursachenstatistik ungeeignet sind.

Schlussfolgerungen Ärzte müssen dafür
sensibilisiert werden, Leichenschauscheine ordnungsgemäß
auszufüllen. Die Obduktion führt sehr häufig zu einer
Änderung des Grundleidens, weswegen die Obduktion eine wichtige
Qualitätskontrolle der Todesursachenfeststellung bleibt. Das ICD-10
Kodieren ist keine primär ärztliche Tätigkeit und sollte
nicht gesetzlich von Ärzten eingefordert werden.
Crystalloid Administration Is Associated with the Recovery of Pediatric Elective Roux-en-Y Hepaticojejunostomy
Authors: Tan Xingqin , Liu Jianxia , Guo Chunbao
Published: January 2019

Introduction Intraoperative fluid administration is important for postoperative recovery and might be associated with postoperative complications.

Materials and Methods This retrospective review included 471 patients who underwent Roux-en-Y hepaticojejunostomy. Patients were separated into two groups based on whether they received low (<15.27 mL/kg/h) or high (>15.27 mL/kg/h) volumes of corrected crystalloid fluids. Propensity score matching was performed to adjust for any potential selection bios for the two groups. In 192 matched patients, clinical outcomes, including postoperative complications and length of hospital stay, were compared.

Results Higher use of diuresis (p = 0.027) was found in the high fluid group. Receiving low volumes of crystalloids was associated with postoperative gastrointestinal functional recovery, reflected by the first defecation (odds ratio [OR], 0.69; 95% confidence interval [CI], 0.31–1.07; p = 0.047) and first bowel movement (OR, 0.56; 95% CI, 0.38–0.98; p = 0.013). However, the occurrence of renal complications did not show significant differences between the groups. A lower postoperative complication rate (OR, 0.54; 95% CI, 0.42–0.94; p = 0.016) was noted in patients with low crystalloids compared with high crystalloids. The total length of hospital stay was longer in patients with high crystalloid fluid (9.21 ± 3.24 days) than patients with low volumes (7.83 ± 2.58 days; p = 0.012).

Conclusion Low crystalloid fluid administration was associated with favorable postoperative outcomes.
Assessing variation in assemblages of large marine fauna off ocean beaches using drones
Authors: Kelaher Brendan P. , Colefax Andrew P. , Tagliafico Alejandro , Bishop Melanie J. , Giles Anna , Butcher Paul A.
Published: January 2019

The turbulent waters off ocean beaches provide habitat for large marine fauna, including dolphins, sharks, rays, turtles and game fish. Although, historically, these assemblages have proven difficult to quantify, we used a new drone-based approach to assess spatial and temporal variation in assemblages of large marine fauna off four exposed beaches in New South Wales, Australia. In total, 4388 individual large marine animals were identified from 216 drone flights. The most common taxa, bottlenose dolphins (Tursiops spp.) and Australian cownose rays (Rhinoptera neglecta), occurred in 25.5 and 19.9% of flights respectively. White (Carcharodon carcharias), bull (Carcharhinus leucas) and other whaler (Carcharhinus spp.) sharks were observed in <1% of flights. There was significant variation in the structure of assemblages of large fauna among beaches, with those adjacent to riverine estuaries having greater richness and abundance of wildlife. Overall, drone surveys were successful in documenting the spatio-temporal dynamics of an impressive suite of large marine fauna. We contend that emerging drone technology can make a valuable contribution to the ecological information required to ensure the long-term sustainability of sandy-beach ecosystems and associated marine wildlife.
Mixed-methods needs analysis of a Chinese language program
Authors: Wang Haidan , Sun Yunhe
Published: January 2019

With the aim of improving a Chinese language program by incorporating defensible curricula, this study surveyed 213 stakeholders to arrive at a panoramic profile of the program’s needs. A mixed-methods research design with multiple types of data triangulation was employed to achieve a balanced quantitative and qualitative exploration of these needs. To redress a lack of comprehensive studies of Chinese learning needs in higher education, this study investigated: (a) program components that were perceived differently by students and teachers; (b) whether, how, and why lower-level learners diverged from upper-level ones with regard to communicative skills and instructional-approach preferences; and (c) any possible insights for program improvement from both micro- and macro- perspectives. In addition to discussing this study’s reliability and validity, the researchers offer recommendations for potential program restructuring and for Chinese language instruction more generally. The paper concludes with implications for future studies, and how its findings might be utilized for program sustainability and improvement.
Effect of obstacle strength and spacing on the slope of Haasen plot
Authors: Mishra Sumeet , Beura Vikrant Kumar , Singh Amit , Yadava Manasij
Published: January 2019

The rate sensitivity of multiple obstacle aluminium alloy system was measured using the stress relaxation method. A discrepancy was observed between the slope of the Haasen plot (rate sensitivity of dislocation–dislocation interaction) in pure metals and in alloys strengthened by multiple obstacles. Considering a simplifying assumption of the constant obstacle force–distance profile, it is suggested that slope of the Haasen plot is governed by glide dislocations’ length taking part in a thermally activated event. The relative strength and spacing of obstacles (forest dislocations, solutes and precipitates) is proposed to affect the thermally activated dislocation length, which in turn manifests as the difference in slope of the Haasen plot.
TEM ExosomeAnalyzer: a computer‐assisted software tool for quantitative evaluation of extracellular vesicles in transmission electron microscopy images
Authors: Kotrbová Anna , Štěpka Karel , Maška Martin , Pálenik Jakub Jozef , Ilkovics Ladislav , Klemová Dobromila , Kravec Marek , Hubatka František , Dave Zankruti , Hampl Aleš , Bryja Vítězslav , Matula Pavel , Pospíchalová Vendula
Published: January 2019

Extracellular vesicles (EVs) function as important conveyers of information between cells and thus can be exploited as drug delivery systems or disease biomarkers. Transmission electron microscopy (TEM) remains the gold standard method for visualisation of EVs, however the analysis of individual EVs in TEM images is time‐consuming if performed manually. Therefore, we present here a software tool for computer‐assisted evaluation of EVs in TEM images. TEM ExosomeAnalyzer detects EVs based on their shape and edge contrast criteria and subsequently analyses their size and roundness. The software tool is compatible with common negative staining protocols and isolation methods used in the field of EV research; even with challenging TEM images (EVs both lighter and darker than the background, images containing artefacts or precipitated stain, etc.). If the fully‐automatic analysis fails to produce correct results, users can promptly adjust the detected seeds of EVs as well as their boundaries manually. The performance of our tool was evaluated for three different modes with variable levels of human interaction, using two datasets with various heterogeneity. The semi‐automatic mode analyses EVs with high success rate in the homogenous dataset (F1 score 0.9094, Jaccard coefficient 0.8218) as well as in the highly heterogeneous dataset containing EVs isolated from cell culture medium and patient samples (F1 score 0.7619, Jaccard coefficient 0.7553). Moreover, the extracted size distribution profiles of EVs isolated from malignant ascites of ovarian cancer patients overlap with those derived by cryo‐EM and are comparable to NTA‐ and TRPS‐derived data. In summary, TEM ExosomeAnalyzer is an easy‐to‐use software tool for evaluation of many types of vesicular microparticles and is available at http://cbia.fi.muni.cz/exosome‐analyzer free of charge for non‐commercial and research purposes. The web page contains also detailed description how to use the software tool including a video tutorial.
Sporadic acoustic neuroma
Authors: Borsetto Daniele , Faccioli Chiara , Zanoletti Elisabetta
Published: January 2019

Purpose:

To date, early diagnosis of vestibular schwannoma is becoming more and more frequent. This involves an increasing number of small tumors with good hearing. Hearing preservation is thus becoming the goal of each therapy of small acoustic neuroma. The aim of this review was to analyze the treatment options for sporadic vestibular schwannoma (observation, radiotherapy, surgery), in terms of long-term cure for the disease with minimal morbidity, in order to ascertain which treatment option offers the best function preservation rates, especially in terms of hearing.

Method:

Seven hundred and fifty recently published representative case series treated with various options, focusing on hearing preservation, were identified in the PubMed database, and then screened based on parameters preliminarily established.

Results:

From a critical analysis of the results, some critical issues emerged. As to begin, a proper comparison of hearing outcomes among the various options is impossible. Observation and radiotherapy seem to offer good short-term results, but most studies revealed a significant bias due to the lack of long-term follow up data. As for surgery, the results varied considerably due to differences in surgeons’ expertise, patient selection criteria, and other institutional factors.

Conclusions:

Hearing preservation, together with hearing rehabilitation in VS is the current most-debated topic in the therapy of sporadic VS. Thus, the need of long-term, high quality and homogenous data in order to analyze and compare the hearing functional outcome within the observation, radiotherapy, and surgery.
Hyperacusis and social media trends
Authors: Deshpande Aniruddha K. , Deshpande Shruti Balvalli , O’Brien Colleen A.
Published: January 2019

Purpose:

In recent years, social media has taken on a new role of helping spread awareness about numerous health conditions, including hyperacusis. Individuals with hyperacusis, which is an atypical response to sound that individuals with normal hearing would find acceptable, are turning to social media platforms to learn about and seek guidance regarding their condition, to communicate with healthcare providers, as well as to find support in other members of the hyperacusis community. The purpose of this study was to investigate trends of social media portrayal of hyperacusis.

Methods:

This investigation systematically analyzed and quantified information related to hyperacusis on three currently popular social media platforms – Facebook (pages and groups), Twitter and YouTube. Further, we noted participation trends across the platforms. The keyword ‘hyperacusis’ was searched on each platform, and results were manually scraped by two reviewers based on numbers of ‘likes’, ‘members’, ‘followers’, ‘views’, ‘comments’ and other social media metrics.

Results:

Over half of the recorded online activity was seen on YouTube, followed by Facebook pages. YouTube was dominated by videos of individuals sharing their experiences with hyperacusis, while Facebook pages were a popular platform for service providers like audiologists. Misinformation and other false claims were found across all platforms, but predominantly on Facebook pages and YouTube.

Conclusions:

This investigation suggests that individuals in the hyperacusis community turn to social media to learn about their condition and share their experiences. Results of this investigation will equip audiologists with information regarding the current portrayal of hyperacusis online and on social media platforms. Audiologists and other hearing health professionals may use these findings to better counsel patients with hyperacusis.
Ambient noise levels and hearing screening outcomes
Authors: Kanji Amisha
Published: January 2019

Purpose:

The current study aimed to determine the mean ambient noise levels within a risk-based newborn hearing screening (NHS) programme. It further aimed to investigate the relationship between the ambient noise levels and the screening outcome. A descriptive, longitudinal, repeated measures, within-subjects design was employed. Three hundred and twenty-five neonates from two public sector hospitals were enrolled in an NHS programme.

Methods:

These neonates underwent an initial hearing screening in the wards, and were thereafter booked for a repeat hearing screening which was conducted in an outpatient clinic within the hospital setting. Screening included transient evoked otoacoustic emissions (TEOAEs), distortion product otoacoustic emissions (DPOAEs) and automated auditory brainstem response (AABR). The maximum ambient noise levels were measured and recorded for each screening session. Data related to mean ambient noise levels were analysed using descriptive statistics. The independent samples t-test and the Wilcoxon rank sum test were used to determine the association between the ambient noise levels and screening outcomes.

Results:

Results indicated that the ambient sound levels were significantly higher for ears which referred, compared to ears which passed.

Conclusion:

Findings from the current study highlight the need for monitoring of ambient noise levels across all screening contexts, and consideration of the inclusion of sound level measurements when planning for hearing screening programmes, particularly for contexts where environmental adaptations may not be possible.
Audiovestibular evaluation after bariatric surgery
Authors: Elsanadiky Hanaa
Published: January 2019

Objectives:

In this research, we will focus on the problem of balance disorders reported by some patients following bariatric surgery. We will determine the most sensitive tests for predicting vestibular disorders in bariatric patients and identify the correlations between vestibular investigations and laboratory investigations.

Design:

All subjects who participated in this study were subjected to basic audiological evaluations, vestibular evaluations and laboratory investigations.

Study sample:

Subjects who participated in this study were classified into two groups: the control group, which included 12 volunteer subjects and the bariatric group, which included 19 subjects who had different types of bariatric and experiencing vertigo symptoms.

Results:

Laboratory investigations revealed that bariatric patients had low Vitamin D, B1, Na and Mg levels. A comparison between the vertigo symptoms and the laboratory investigation showed a significant correlation with the vestibular tests. The pursuit test and saccade had high positive correlations with vertigo characteristic. Sensitivity was 76.5% and specificity was 85.7%.

Conclusions:

Saccade latency and pursuit gain were the most sensitive tests for predicting vestibular disorders in bariatric patients. There were correlations between the vestibular investigations and the laboratory investigations. Auditory and vestibular symptoms may occur prior to other manifestations.
Revisiting the Farm Size‐Productivity Relationship Based on a Relatively Wide Range of Farm Sizes: Evidence from Kenya
Authors: Muyanga Milu , Jayne T S
Published: January 2019

This paper revisits the inverse farm size‐productivity relationship in Kenya. The study makes two contributions. First, the relationship is examined over a much wider range of farm sizes than most studies, which is particularly relevant in Africa given the recent rise of medium‐ and large‐scale farms. Second, we test the inverse relationship hypothesis using three different measures of productivity including profits per hectare and total factor productivity, which are arguably more meaningful than standard measures of productivity such as yield or gross output per hectare. We find a U‐shaped relationship between farm size and all three measures of farm productivity. The inverse relationship hypothesis holds on farms between zero and 3 hectares. The relationship between farm size and productivity is relatively flat between 3 and 5 hectares. A strong positive relationship between farm size and productivity emerges within the 5 to 70 hectare range of farm sizes. Across virtually all measures of productivity, farms between 20 and 70 hectares are found to be substantially more productive than farms under 5 hectares. When the analysis is confined to fields cultivated to maize (Kenya's main food crop) the productivity advantage of relatively large farms stems at least partially from differences in technical choice related to mechanization, which substantially reduces labor input per hectare, and from input use intensity.
P-curving x-phi: Does experimental philosophy have evidential value?
Authors: Stuart Michael T , Colaço David , Machery Edouard
Published: January 2019

In this article, we analyse the evidential value of the corpus of experimental philosophy (x-phi). While experimental philosophers claim that their studies provide insight into philosophical problems, some philosophers and psychologists have expressed concerns that the findings from these studies lack evidential value. Barriers to evidential value include selection bias (i.e., the selective publication of significant results) and p-hacking (practices that increase the odds of obtaining a p-value below the significance level). To find out whether the significant findings in x-phi papers result from selection bias or p-hacking, we applied a p-curve analysis to a corpus of 365 x-phi chapters and articles. Our results suggest that this corpus has evidential value, although there are hints of p-hacking in a few parts of the x-phi corpus.
Three Simple Steps for Refining Transcutaneous Lower Blepharoplasty for Aging Eyelids: The Indispensability of Micro-Autologous Fat Transplantation
Authors: Huang Shu-Hung , Lin Yun-Nan , Lee Su-Shin , Huang Yu-Hao , Takahashi Hidenobu , Chou Chih-Kang , Lin Tsung-Ying , Chen Rong-Fu , Kuo Yur-Ren , Lai Chung-Sheng , Lin Sin-Daw , Lin Tsai-Ming
Published: January 2019

Background

Lower blepharoplasty has been used for rejuvenating lower eyelids, and diverse modifications have been used to treat conjunct deformities at the tear trough/lid-cheek junction. Strategies for recontouring prominent tear trough/lid-cheek junctions, including orbital fat manipulation, have been reported with good results in the literature. Micro-autologous fat transplantation (MAFT) is a previously unevaluated, potentially advantageous approach to blending the prominent tear trough/lid-cheek junction.

Objectives

We determined the long-term results after 3-step transcutaneous lower blepharoplasty with MAFT for patients with aging eyelids and prominent tear trough/lid-cheek junctions.

Methods

We evaluated 205 patients with aging lower eyelids who underwent transcutaneous lower blepharoplasty with MAFT between October 2010 and September 2016. The 3-step procedure involved a subciliary elliptical skin excision, resection of 3 orbital fat compartments, and MAFT for the tear trough/lid-cheek junction employing a MAFT-GUN under intravenous anesthesia.

Results

The mean patient age was 52 years (range, 34-78 years). The mean operating time was 61 minutes. The mean fat volumes delivered to the tear trough/lid-cheek junctions were 2.80 mL and 2.76 mL for the left and right sides, respectively. The average weights of the 3 resected orbital fat compartments were 0.58 g for the left side and 0.56 g for the right side. Patients showed significant improvement and maintenance at an average follow-up of 60.2 months (range, 18-90 months).

Conclusions

Three-step transcutaneous lower blepharoplasty with MAFT is an effective, reliable, and promising method with high patient satisfaction and minimal risk of complications. Long-term results demonstrated its utility for aging lower eyelid treatment.

Level of Evidence: 4