bluuebunny/crossref_metadata_2025 huggingface dataset:
3D-bioprinting in reconstructive surgery: Opportunities and prospects
Authors:   Russian University of Medicine, Subbotina Elizaveta , Cherkiev Adam ,   Kuban State Medical University, Lendych Viktor ,   Kuban State Medical University, Chizhova Ekaterina ,   I. N. Uliyanov Chuvash State University, Makarova Yuliana ,   I. N. Uliyanov Chuvash State University
Published: January 2025

3D bioprinting is one of the advanced technologies that is actively transforming approaches to reconstructive plastic surgery, offering new opportunities for the creation of personalized, biocompatible, and functional tissues and organs. This field allows the fabrication of complex tissue structures, significantly improving the quality of recovery after trauma and surgical interventions. This review covers the key principles and technologies of 3D bioprinting, its
application in reconstructive surgery, as well as the prospects for further development of this method. Special attention is given to the materials used in creating 3D structures, including bioinks, synthetic and natural polymers, as well as extracellular matrices that enable the
formation of tissues similar to natural ones. Layered tissue construction technologies, such as inkjet, laser printing, and extrusion, are used to create individualized anatomical models that help surgeons carefully plan surgeries. Despite significant achievements, challenges remain, such as the development of new biomaterials, improving model accuracy, and reducing equipment costs, which limit the widespread adoption of 3D bioprinting in clinical practice. Nevertheless, its potential to significantly improve surgical outcomes and enhance patients’ quality of life is undeniable.
Settling cross-border disputes of a private law nature as part of the legal regulation mechanism
Authors:   Herzen State Pedagogical University of Russia, Smorgunova Valentina Iu. , Aleshina Alexandra V. ,   Herzen State Pedagogical University of Russia, Kosovskaia Viktoriia A. ,   Herzen State Pedagogical University of Russia
Published: January 2025

Private legal relations with a foreign element require specific legal regulation, highlighting the immediate need for an effective resolution mechanism. The article explores the interconnection and interaction of the various components within the legal regulation mechanism, which is conceptualized as a complex and multifaceted system. This system encompasses the rulemaking, the implementation of legal rules and the utilization of state coercion in instances of non-compliance. The authors made an effort to determine the distinct features of the settlement process for cross-border disputes of a private law nature, which constitutes an essential component of the legal regulation mechanism. The article consistently covers the challenges that arise when law enforcement officers address the international treaties and customs, select an appropriate legal order and apply foreign law if conflicts-of-laws rule refers to it. Particularly, such institutions of private international law as “the problem of qualification of legal concepts”, “remission” and “transmission”, “preliminary question” were analyzed. Special emphasis is given to the challenges encountered by law enforcement officers when determining the content of foreign law, which has been chosen as applicable following the resolution of a conflict of laws. Despite the various methods offered by the legislator to determine the content of foreign law, practical evidence reveals persistent challenges arising from the ambiguity surrounding their sequence and extent of application. In certain instances, the application of foreign law may be accompanied by substantial limitations, either due to their inapplicability based on the contradictions with the public order of the state, or the existence of directly applicable rules of a super-imperative nature in the law of the court’s country.
Confiscation and other procedures for deprivation of illegally acquired (criminal) proceeds under the laws of Russia and foreign jurisdictions
Authors:   MGIMO University, Shatailyuk Ekaterina E.
Published: January 2025

The article focuses on the problems of effective combating profit-driven crimes and the implementation of the “crime does not pay” principle in the Russian legislation. The author analyzes the existing civil and criminal mechanisms for the return of assets in Russia, as well as the issues of a special unexplained wealth procedure. The paper reveals the deficiencies of each instrument that result in practical challenges, faced by law enforcement agencies, the judiciary and victims, while restoring the situation that existed prior to commission of a crime. In the search for possible solutions to the problems, legal acts of the European Union, international conventions and the legislation of the certain jurisdictions (Germany and the United States) were reviewed in order to explore the alternative procedures for reducing the “profitability” of economically-motivated crimes and compensating victims. In particular, the article considers non-conviction-based confiscation models, their expansion and application conditions, maintaining balance between confiscation of assets and the interests of victims, as well as certain aspects of post-conviction assets tracing and confiscation. In conclusion, the author introduces the concept of modernizing the confiscation system in the Russian Federation, differentiating between evidentiary standards used to determine a person’s guilt and to confiscate illegally acquired assets, with reference to foreign experience in using confiscated property to compensate for damage caused by a crime; proposes supplements to the criminal procedure law providing for the application of extended and independent confiscation; identifies possible outlines of the institution to sever “criminal case against assets” from “criminal case against a person” when the latter is referred to the court (in respect of the highly profitable crimes).
Using applications of machine learning models for predicting and analyzing scour depth at the submerged weir
Authors: Ghanim Abdulnoor , Ahmed Talha , Ahmad Mahmood , Taha Abubakr Taha Bakheit , Babur Muhammad , Kubińska-Jabcoń Ewa , Badshah Muhammad Usman
Published: January 2025

Weirs are designed to stabilize rivers, grade control, and raise upstream water levels. The failure of these structures is primarily due to local scour at the structural site. Consequently, an accurate estimate of the likely scour depth at the structure is critical for weir design safety and economy. This study proposes machine learning models for scour depth prediction at submerged weirs by introducing advanced gradient boosting algorithms, namely gradient boosting (GB), categorical boosting (CatBoost), adaptive boosting (AdaBoost), and extreme gradient boosting (XGBoost). A database consisting of 308 cases was collected for model calibration and evaluation. The results demonstrate that the GB algorithm is very accurate, with coefficients of determination of 0.99610 and 0.96222 for the training and testing datasets, respectively. The GB model outperforms other developed models, such as support vector regression, decision tree, and ridge models, in the literature. A sensitivity analysis study has determined that the morphological jump parameter is the most significant factor, whereas the normal flow depth on the equilibrium bed slope is the least significant factor in predicting the ds under the submerged weir.
Priorities in Strategic Personnel Management in Tourism and Hospitality
Authors: Donskova L. I. , Zavodchikova M. G.
Published: January 2025

Topicality of problems of strategic HR management in complicated and uncertain current conditions is proved by importance of personnel in the field of tourism and hospitality and affected by professional qualities of employees, which stipulates the level of tourist satisfaction, efficiency and competitiveness of organization as a whole. The goal of the research is to identify priorities among alternative opportunities in strategic HR management in enterprises of tourist and hospitality industry. Methodology of the research is based on integration of systemic and strategic management. The model of strategic HR management and empiric data at enterprises of the hotel type show high personnel turnover, uneven employment, absence of social ways of stimulation, importance of economic ways of motivation usually available in large hotels. Therefore, each enterprise elaborates its own system of employee retaining on the basis of balancing material and non-material incentives and forms a complex approach to methods of HR management. Working-out of priorities in strategic HR management rests on provisions of strategy of organization development and its key components. As alternative opportunities the following trends were proposed: innovation HR management with IKT elements, research and analytical approach, Well-being concept.
Historic Peculiarity of Russian Modernization Processes
Authors: Platonov D. N. , Zolotareva V. P.
Published: January 2025

The article tries to restore interest in the concept of economy morphology in academic community that was put forward at the Faculty of Economics in the Moscow University in 2004. It was a scientific hypothesis explaining evolutional features of transformations by analyzing internal structural changes. The authors use the term ‘economy morphology’ that gives an opportunity to specify the development of Russian economy both within the period being investigated and the current one. Comparative analysis of economic evolution styles in Europe-Asia economy systems from ancient times to the early 20th century allows us to advance an assumption about multi-variability of development demonstrated and proved in economic morphemes. Conceptual description of economic forms present in Russia was provided by examples given in the Domostroy and in works by I.V. Pososhkov and V.N. Tatischev, the founders of the Russian school of economics. The authors pay special attention to dubious foundation forming Russian economy morphology and affecting all stages of modernization processes in Russia. The importance of spirituality is highlighted that provides internal stability to any economic modification. It was underlined that this approach gives a chance to substantiate historic peculiarity of the Russian economic system that became evident in the process of modernization restructuring in the 19th – early 20th century. The authors came to the conclusion that morpheme approach is necessary to understand both the previous way of development and the current standing of Russian economy, prospects of its progress in conditions of global transformation of economic relations.
Developing the Triad of Finance Indicators to Identify and Regulate Risks Dealing with Asset Functioning in Big, Medium and Small Corporations
Authors: Galasova M. V.
Published: January 2025

Developing the triad of finance indicators to reveal in proper time and minimize risks dealing with asset functioning in organizations of different business scale can have a positive impact on the quality of assets and sustainability of company work at present and in the future. During the research works by Russian and overseas authors were studied, it showed that they used different indicators to estimate the finance standing in the system of corporate finance management. The triad of finance indicators includes finance autonomy, tension, multiplier of own sources, criterial values of which shall comply with the golden rule of finance management. The goal of the research is to introduce and substantiate the triad of finance indicators used for timely identification and minimization of risks connected with asset functioning in corporations. As a result in theoretical line of the research the triad of logically interconnected finance indicators was advanced and the criterial level of their estimation was put forward. As for the practical line of the research, violation of the golden rule of finance management was revealed in big, medium and small corporations.
Проблемное поведение собак-компаньонов: важно для человека, важно для общества
Authors: Фомина Анна С. , Васильев Павел В. , Крикунова Анастасия А. , Крахмалев Тихон К. , Ермаков Павел Н. , Буркова Валентина Н. , Сердюк Татьяна С. , Ермаков Алексей М.
Published: January 2025

The relationship between a dog and a person as a predictor of the occurrence of behavioral disorders. Currently, the issue of problematic behavior of companion dogs is becoming particularly relevant. The most important reason for the insufficient adaptation and socialization of dogs in society, ineffective training, and a decrease in the quality of life of animals is the lack of a scientifically based concept for identifying the causes of behavioral disorders and their elimination. It is noted that it is necessary to study early socialization, the formation of the type of attachment between the dog and the owner as a predictor of possible anxious or aggressive behavior.
The purpose of the study. The study of behavioral disorders in domestic companion dogs. The article provides an analysis of 132 modern studies on various aspects of problematic behavior. 
The occurrence and impact of behavioral disorders in dogs. There is a correlation between aggressive and anxious behavior of dogs with the type of attachment and the way of communication with the owner. The neuroticism of the owner and the avoidant type of attachment are one of the key factors in the formation of behavioral signs of anxiety in a dog. For animals with anxiety disorders, a decrease in life expectancy, an increase in the frequency of aggressive manifestations, and a violation of communication with the owner are shown, which ultimately leads to a decrease in the quality of life in the "owner-dog" dyad. 
Identification of behavioral problems in dogs. Biochemical methods for the diagnosis of behavioral disorders are based on the analysis of the concentration of serotonin, cortisol, oxytocin and dopamine in biological fluids and dog hair. Physiological methods of diagnosing behavioral disorders are based on the assessment of ECG and thermometry. Surveys of dog owners and instrumental and behavioral test samples are also used.
Установочный эффект у детей дошкольного и младшего школьного возраста, формируемый иллюзиями Понзо и Мюллера-Лайера
Authors: Романова-Африкантова Наталия И. , Карпинская Валерия Ю. , Ляховецкий Всеволод А.
Published: January 2025

Introduction. A perceptual set is a specific psychological mechanism that shapes the perception of objects based on prior experience, current goals, and the conditions of perception. Previous studies have shown that both realistically different and illusorily distorted objects can create a perceptual set effect in adults.
The aim of this study is to experimentally verify the formation of the perceptual set effect in children using the Müller-Lyer and Ponzo illusions, in comparison with the presentation of segments that differ in length.
Methods. The sample consisted of 26 children with an average age of 6.45 years. The stimulus material was presented in three series: real-different segments (with actual size differences), the Ponzo illusion, and the Müller-Lyer illusion. Each series included 10 setup stimuli and 5 pairs of equal segments to assess the perceptual set effect. Prior to the main experiment, all children underwent diagnostics of visual perception maturity and were divided into two groups based on their level of visual perception constancy maturity.
Results. Statistical analysis of the experimentally obtained data revealed a perceptual set effect in children with a high level of visual perception constancy maturity, observed in both the series with real-different segments and the Müller-Lyer illusion. Children with low constancy maturity did not exhibit a perceptual set effect. The Ponzo illusion did not produce a perceptual set effect in either group of children.
Discussion. The results obtained should be regarded as new evidence supporting the idea that the Ponzo and Müller-Lyer illusions belong to distinct categories of illusions.
Функции производственных групп по отношению к их членам: роль структурно-количественных характеристик
Authors: Сидоренков Андрей В. , Обухова Юлия В. , Ерибекян Анастасия А. , Игнатов Даниил С.
Published: January 2025

Introduction. This paper presents the results of a study of the relationship of the size (the total number of group members and the number of informal subgroup members) and gender and age composition of work groups with the extent to which they implement functions in relation to group members. The functions include (1) creating possibilities for realization of individual goals and meeting individual needs; (2) protection from external social threats; (3) informing (providing information to) members; (4) educating members; (5) adaptation of (providing adaptive capacities to) members; and (6) providing control and regulation. Methods. The study was conducted in 49 departments of companies with 4 to 14 employees (n = 290; 75.35 % women and 24.65 % men aged 21–70 years). In the first stage of the study, the Group Profile computer program was used, which included a formalized algorithm for identifying informal subgroups in the group. In the second stage, a printed form of a questionnaire on group functions related to group members was used. Data were analyzed using descriptive statistics, the Pearson Chi-square test, the nonparametric Mann-Whitney U-test, and the bias-corrected bootstrap. Results. The number of members included in informal subgroups (in relation to total group size) has a direct positive effect, while the total group size has an indirect negative effect (mediated by the number of group members in subgroups) on the functions that work groups carry out in relation to group members. None of the functions correlated with the gender-related heterogeneity of groups. However, the function of providing information to members negatively correlated with the age-related heterogeneity of groups. Discussion. This study presents the first step toward understanding the antecedents of the functions that work groups implement in relation to group members. The results obtained can be used by managers and psychologists to solve practical problems. Further studies will investigate group composition based on other properties and group socio-psychological characteristics as antecedents of the functions that work groups carry out in relation to group members.
Исследование особенностей самооценки и самоотношения у участников локальных боевых действий, получивших травмы и увечья
Authors: Гришина Анастасия В. , Романова Марина С.
Published: January 2025

Introduction. In a person's life, a traumatic life situation or incidental life experience may lead to various dysfunction on both physiological and psychological levels. The aim of the study is to identify the specifics of self-esteem, self-attitude and attitudes towards life in people who were physically injured as a result of a traumatic event. Methods. The study involved 220 men with a variety of physical injuries and traumas. We used Sacks Sentence Completion Test, SSCT by J. Sacks, S. Levy and The Twenty Statements Test (TST) ("Who Am I?") by M. Kuhn, T. McPartland. Results. Individuals who had undergone amputations showed normal, healthy levels of self-esteem, while individuals with severe, life-threatening body injuries showed low levels of self-esteem. There are statistically significant differences in self-attitude and attitude towards different aspects of life among people with varying degrees of physical traumas and injuries.  Men with severe, life-threatening body injuries showed the most pronounced feelings of guilt; they also had flashbacks to past experiences within the experience of the traumatic situation. Discussion. Researches of self-esteem and self-attitude in individuals who have suffered various physical injuries and traumas confirm our results. Studies confirm that people with injuries of moderate and severe forms have different attitudes towards various aspects of their lives and specifics of guilt feeling formation compared to people who have experienced amputation surgeries.
Виктимные типы личностей и их проявление у пожилых людей
Authors: Будякова Татьяна П. , Михеева Екатерина В.
Published: January 2025

Introduction. Legal psychology rarely examines elderly crime victims, which limits the effectiveness of psychological crime prevention strategies for elderly people. Methods. The study included 50 participants aged 55 to 74. Biographical interviews, court case materials, and judicial and investigative practice documents were used for data collection. We analyzed instances of victim and anti-victim behavior among elderly participants, including behaviors not typically disclosed in autobiographical accounts. The data were processed using content analysis, descriptive statistics, and Student’s t-test. Results. The hypothesis that victimization is not directly caused by the personality type of older individuals was partially supported. Depending on the circumstances, the same personality type can both contribute to victimization and prevent it. Victimization is not solely determined by personality traits, as characteristics such as aggressiveness, passivity, activity, initiative, and neutrality can contribute both to victim and anti-victim behavior. However, the hypothesis was not supported for one personality type in D.V. Rivman’s victim typology: the non-critical type. Discussion. In our view, an anti-victim personality is one that exhibits specific behavioral responses and is able to choose an appropriate reaction to a pre-crime situation, one that aligns with the criteria for victimization, regardless of how they typically respond in other social contexts.
Комплексная экспресс-диагностика реабилитационного потенциала участников боевых действий с инвалидностью
Authors: Соловьева Ольга В. , Лукьянов Алексей С. , Борозинец Наталья М. , Прилепко Юлия В. , Браккер Елена Л.
Published: January 2025

Introduction. The article presents the development of express-methodology for diagnosing the psychological component of rehabilitation potential of persons who received disability during combat operations and special military operations. Based on the experience of diagnostic examinations of other components of rehabilitation potential (psychophysiological, professional and pedagogical, social and environmental), the indications and indicators for complex express-diagnostics were selected, the optimized structure of which formed the basis of the corresponding methodological tool. Cognitive, affective and conative representants were identified as structural elements of the psychological component of the rehabilitation potential of the personality.
Methods. For the purpose of approbation and formalization of the methodology, 345 respondents aged 18 to 42 years, 54% female and 46% male, took part in the study. The methods used as a basis for validation were the test "Assessment of personality adaptability" (S.I. Yakovenko), J. Endicott quality of life assessment scale, I. Schuller, A. Komuniani optimism and activity scale, "Self-assessment of conflict" test (A.Y. Antsupov, A.I. Shipilov), "Resilience test" by S. Muddy, express-diagnostics of cognitive abilities (G.S. Nikiforov).
Results. The obtained instrument was tested for reliability, the optimal number of indicators presupposes 22 items. Based on confirmatory factor analysis, they are combined into a three-factor model, which has high values ​​of verification indicators of compliance of this model with the data. High indicators of convergent and divergent validity were obtained by comparing the data with the results of existing standardized methods.
Discussion. Three factors in the model of the psychological component of the rehabilitation potential of the individual are represented by the factor "Behavior", including "Adaptability", "Quality of life" and "Optimism", the factor "Emotionality", including "Intrapersonal conflict" and "Neurosensory stability" and the factor "Cognition", including "Logic", "Memory" and "Attention". The levels of assessment of both individual factors and the complex indicator of the psychological component of the rehabilitation potential of the individual are identified, which allows us to speak about the suitability of this tool for use by specialists when working with individuals with disabilities acquired during combat operations and special military operations.
Genes enterotoxigênicos e resistência à meticilina em Staphylococcus aureus isolados de leite caprino
Authors:   , Rebouças Germana Guimarães
Published: January 2025

O objetivo do presente trabalho foi investigar a presença de genes enterotoxigênicos e de resistência à meticilina em Staphylococcus aureus isolados de leite caprino obtido de produtores do estado do Rio Grande do Norte. Para a realização do estudo, realizou-se a pesquisa de S.aureus em 49 amostras de leite caprino. O isolamento foi realizado em placas Petrifilm , modelo Staph Express 3M e identificadas bioquimicamente. Em seguida, os isolados foram submetidos a avaliação quanto ao perfil de resistência a antibióticos, utilizando a técnica de difusão em discos em Agar Mueller-Hinton. Seguiu-se com a realização da reação em cadeia pela polimerase (PCR) para pesquisa dos seguintes genes selecionados: 16S rRNA (para identificação molecular dos S. aureus), mecA (que caracteriza S. aureus resistente à meticilina) e genes enterotoxigênicos (sea, seb-sec, sec, sed, see, seg, seh, sei, sej e tsst-1). Os resultados das análises morfológicas e bioquímicas revelaram que todos os isolados pertenciam a espécie Staphylococcus aureus. Observou-se através do antibiograma realizado um maior percentual de resistência para os antimicrobianos penicilina G (87,75%) e oxacilina (75,51%). Multirresistência foi verificada em 73,46% dos isolados. Com a análise da PCR, confirmou-se que 100% dos isolados eram S. aureus, pela amplificação do gene 16S rRNA. O gene mecA foi detectado em 4,08% das amostras. Na pesquisa de enterotoxinas estafilocócicas (SE), nas amostras confirmadas para S. aureus, houve amplificação em 79,5 % dos fragmentos do gene sej, seguido de 48,9% do gene sei, 22,4% do gene sed, 12,2% para o gene sea, 8,1% para os genes seh e seg e 2% para o gene sec. Não foi observada nenhuma amplificação para os genes seb-sec, see e Tsst-1. As amostras de S. aureus isoladas a partir do leite caprino demostraram presença de genes responsáveis pela produção de toxinas, fato que exige um maior cuidado no tratamento deste leite pela indústria de alimentos. Além disso a resistência aos antibióticos e detecção do gene mecA também leva a preocupação, podendo representar riscos à saúde do consumidor.
Utilização da macroalga Gracilaria birdiae no desenvolvimento de produtos alimentícios
Authors:   , Vasconcelos Bárbara Monique de Freitas
Published: January 2025

O objetivo do trabalho foi utilizar a macroalga Gracilaria birdiae no desenvolvimento de dois produtos alimentícios, buscando elevar o percentual proteico e o consumo de algas. A G. birdiae foi desidratada em secador solar e estufa mecânica a fim de verificar qual o processo que melhor garante seu valor nutricional. A partir da G. birdiae desidratada foram produzidos o biscoito salgado com alga e o bolinho de camarão empanado com alga. Foram realizados a composição centesimal, a análise microbiológica e análise sensorial de ambos produtos. O biscoito foi embalado em atmosfera modificada (100% N2) e armazenado por 180 dias em temperatura ambiente para avaliação da vida de prateleira. O bolinho de camarão foi embalado em diferentes concentrações de atmosfera modificada e armazenados sob refrigeração (4°C) durante 15 dias para avaliação da vida de prateleira. Os resultados demonstraram que a secagem em estufa (60°C) foi a que garantiu melhor qualidade nutricional, sendo que o percentual proteico se destacou (14%). A análise microbiológica da alga in natura estava dentro dos limites da legislação, e para a alga desidratada não foi detectada presença de microrganismos, confirmando os cuidados higiênico-sanitários durante o processamento. O percentual proteico dos produtos desenvolvidos foi o de maior destaque (15% para o biscoito e 16% para o bolinho). A avaliação microbiológica dos produtos demonstrou crescimento de mesófilos (bolinho de camarão com alga) e de bolores e leveduras (biscoito com alga), porém abaixo do limite estabelecido pela legislação. Os produtos desenvolvidos foram bem aceitos na análise sensorial. Os resultados do estudo de vida de prateleira demonstraram que os produtos desenvolvidos se mantiveram estáveis físico-química e microbiologicamente durante todo o período de armazenamento. A atmosfera modificada ATM3 (80% CO2 | 20% N2 | 0% O2) foi a mais eficiente para manter os padrões físico-químicos e microbiológicos do bolinho. A macroalga G. birdiae apresentou percentual proteico elevado, excelente perfil sensorial quando incluído nos produtos alimentícios, e podendo ser considerada promissora como ingrediente na indústria alimentícia.
Avaliação in vitro das atividades biológicas da apitoxina extraída de Apis mellifera do semiárido
Authors:   , Viana Geysa Almeida
Published: January 2025

Os produtos oriundos da colmeia têm oferecido importantes contribuições para a
civilização humana e para economia, e dentre os produtos apícolas o veneno da abelha,
também chamado de apitoxina, talvez seja o mais intrigante devido à suas propriedades
curativas. Ele consiste em uma mistura bastante complexa, e dentre os seus componentes os
que mais se destacam são a melitina e a fosfolipase A2, que representam juntas cerca de 75%
do seu peso seco. A melitina apresenta potencial terapêutico significativo no tratamento de
várias doenças, além de atualmente ser muito utilizada em cosméticos como auxiliar no
retardo do envelhecimento. Nesse estudo, as amostras de apitoxina da abelha Apis mellifera
obtidas no semiárido do Rio Grande do Norte, foram quantificada quanto ao teor de fenóis
totais e suas atividades biológicas in vitro foram investigadas, a saber: atividade antioxidante
através da capacidade sequestrante do radical livre (DPPH); atividade antibacteriana, através
do método de difusão em ágar e atividade antitumoral, através do método colorimétrico MTT.
O teor de fenóis totais obtidos da amostra foram de 3,79 ± 0,3 mg/g (0,37± 0,33 %),
apresentando alta capacidade antioxidante com percentual de 92,59 ± 0,48 % . Em relação à
atividade antibacteriana, a apitoxina da abelha Apis mellifera apresentou efeito positivo contra
as três estirpes testadas, sendo mais ativa contra a bactéria Klebisiella pneumoniae que foi a
mais sensível, e Staphylococcus aureus a mais resistente. Em relação ao seu potencial
antitumoral, a apitoxina apresentou relevante atividade citotóxica contra as células de
linhagens tumorais HCT-116 (Carcinoma de coloretal humano), HL-60 (Leucemia
promielocítica humana) e MDA-MB435 (Melanoma), possuindo uma maior seletividade para
as linhagens de HCT-116 e HL-60. Por fim, foi possível concluir que a apitoxina da abelha
Apis mellifera obtida na região do semiárido pode ser utilizada na medicina não convencional
como agente antioxidante, antibacteriano e citotóxico.
Molecular Interactions of the Antimicrobial Peptide Tritrpticin with
Mixed Nanoaggregates: A Fluorescence Spectroscopy Study
Authors: Rocha Kaio César Antunes , de Arruda Brasil Maria Carolina Oliveira , Cilli Eduardo Maffud , Salay Luiz Carlos
Published: January 2025

Introduction:

Tritrpticin (TRP3) is a peptide belonging to the cathelicidin family and
has a broad spectrum of antimicrobial activity. However, this class of biomolecules can be easily
degraded in the body, making it necessary to use an efficient transport system. The ability to form
stable nanostructures from the interaction of glycyrrhizin saponin with the pluronic polymer F127
was demonstrated, forming mixed biopolymeric micelles, highly promising as drug carriers.

Objective:

The present work sought to understand the physicochemical interaction of the antimicrobial
peptide TRP3 with the mixed polymeric micelle made from pluronic F127 and the saponin
glycyrrhizin.

Methods:

The interaction of tritrpticin with mixed nanostructured micelles was evaluated through
fluorescence spectroscopy and fluorescence quenching with acrylamide. The experiments were
performed at room temperature (25 ± 1°C), adopting an excitation wavelength set to 280 nm and
emission between 300 and 500 nm, with a slit of 5 nm.

Results:

The interaction of the cationic peptide tritrpticin with the mixed biopolymeric micelles
was observed through the blue shift of the fluorescence emission to shorter wavelengths, proving
the change of tryptophan to a more hydrophobic environment. Through the fluorescence suppression
technique, it was possible to indicate the location of the peptide in the mixed micelles, proving
tritrpticin to be partially inserted inside them.

Conclusion:

It was concluded that tritrpticin interacted with mixed nanostructured micelles, forming
a promising system for biotechnological applications.
In Silico Analysis of Methylprednisolone Derivatives: DFT Studies and
Molecular Docking Analysis Against Monkeypox Protein
Authors: Singh Praveer , Prakash Rohit , Singh Saurabh Kumar , Srivastava Sanjay , Sethi Arun , Singh Ranvijay Pratap
Published: January 2025

Monkeypox is an emerging zoonotic disease caused by the monkeypox virus, a member of
the Orthopoxvirus genus, characterized by symptoms, such as fever and lymphadenopathy, with distinctive skin rashes transmitted through direct contact with infected individuals or animals. Currently,
there is no specific antiviral treatment approved for monkeypox; however, antiviral agents used for
smallpox, such as tecovirimat and brincidofovir, have shown efficacy against monkeypox in laboratory studies. By analyzing recent outbreaks and response strategies, we aim to synthesize steroidal derivatives that may serve as potent therapeutic agents for this infectious disease. In the present research paper, we synthesized the methylprednisolone derivatives (1a-1d) with the help of Steglich
esterification using a dehydrating agent N, Nꞌ-dicyclohexyldicarbodiimide (DCC) and N, Nꞌdimethyl-4-aminopyridine (DMAP) as a catalyst. The structures of all synthesized methylprednisolone derivatives were identified using advanced spectroscopic techniques, including 1
H NMR, 13C
NMR, IR, UV-Vis, and ESI-MS. Experimental values correlated with theoretical predictions through
DFT/B3LYP calculations. Hydrogen bonding and various interactions were thoroughly analyzed
using Bader’s 'Atoms in Molecules' (AIM) theory. The HOMO-LUMO energy gap indicated a high
level of chemical reactivity for the compounds, with Compound 1a exhibiting nonlinear optical
(NLO) behavior due to a high first hyperpolarizability value of 9.06 × 10–30 esu. Molecular docking
studies of methylprednisolone derivatives 1a, 1b, 1c, and 1d against monkeypox protein (4QWO)
revealed binding energies of -10.7 kcal/mol, -11.0 kcal/mol, -8.6 kcal/mol, and -9.3 kcal/mol, respectively. These results suggest that the methylprednisolone derivatives exhibit inhibitory activity
against the monkeypox protein.
Synthesis, Characterization, and Toxicity Studies of Azo Dye Ligand for
Metal Assessment in Different Brands of Lipsticks in Iraq
Authors: Hessoon Haider M. , Alzayd Asawer A.M. , Karam Faiq F. , Kyhoiesh Hussein A.K.
Published: January 2025

This research project focuses on the synthesis and characterization of a novel azo ligand, 4-
CMBP, derived from 2-amino-6-methylbenzothiazole, and its complexes with Co(III) and Ni(II) ions.
The study aims to investigate the structural and biological properties of the ligand and its complexes,
with a particular emphasis on their potential applications in environmental and health sectors. The
ligand and its complexes were characterized using techniques such as melting point measurements,
nuclear magnetic resonance, mass spectrometry, Fourier-transform infrared spectroscopy, UV-Vis
spectroscopy, elemental analysis, atomic absorption spectroscopy, molar conductivity, and magnetic
susceptibility measurements. Biological activities were evaluated through the removal percentages of
Co(III) and Ni(II) from eleven popular brands of lipsticks in the Iraqi market, antimicrobial screening
against bacteria and fungi, in silico ADMET predictions, and anticancer activity tests in human liver
cancer cell lines. Characterization confirmed the successful synthesis of the ligand and the formation
of octahedral complexes with Co(III) and Ni(II) ions. The analysis revealed nickel concentrations
ranging from 0.36 to 3.08 ppm, with varying safety implications. Antimicrobial screening showed
promising activity, and in silico predictions indicated favorable oral bioavailability. The ligand and its
complexes exhibited significant anticancer activity against liver cancer cell lines. The study successfully synthesized and characterized the azo ligand 4-CMBP and its metal complexes, highlighting
their intriguing geometries and promising biological activities, with potential applications in environmental remediation, antimicrobial agents, and anticancer therapeutics.
Clomipramine-Induced Urinary Retention in an Adult Male - A Case Report
Authors: Mehta Priya , Sapovadia Pooja , Purohit Bhargav
Published: January 2025

Background:

Clomipramine, a Tricyclic Antidepressant (TCA), is known for its efficacy in treating Obsessive-compulsive Disorder (OCD). However, it is associated with several side
effects, including urinary retention. This case report discusses the case of a 20-year-old male with
OCD who developed urinary retention following clomipramine administration.

Case Representation:

A 20-year-old male with a one-year history of OCD with psychotic features
was admitted to SIR-T Hospital, Bhavnagar, due to worsening symptoms. He was prescribed
clomipramine along with other psychotropic medications. On the 16th day of hospitalization, the
patient experienced acute urinary retention, necessitating catheterization. Clomipramine dosage
was subsequently reduced, resulting in the resolution of urinary retention. The patient was
discharged after 29 days with no further urinary complications.

Discussion:

The causality assessment suggested a probable link between clomipramine and urinary retention, supported by the Naranjo Scale, WHO-UMC criteria, and literature. The anticholinergic properties of clomipramine likely contributed to the condition. Despite its side effects,
clomipramine remains a valuable treatment for OCD, requiring careful dose management to mitigate adverse effects.

Conclusion:

Clinicians should be vigilant for urinary retention in patients receiving
clomipramine, especially at higher doses. Regular monitoring and dose adjustments are crucial for
managing this side effect without compromising the therapeutic benefits for OCD.
Machine Learning Guided Lyric-analysis Peer Support Intervention for Psychological Distress in African Population: A BOM Conceptualized Framework
Authors: Banda Lucas , Mokgatle Mathildah Mpata , Oladimeji Olanrewaju
Published: January 2025

Background

Sub-Saharan Africa faces a significant burden of mental health challenges, including depression and anxiety, particularly among vulnerable populations such as women and individuals living with HIV. This study proposes a machine learning-guided Lyric Analysis Peer Support Intervention (LAPSI) to predict psychological distress and inform interventions. The study utilizes machine learning to generate risk profiles, presenting an innovative application in identifying psychological distress risk factors for developing targeted interventions.

Objective

The objective of this study is to utilize machine learning models to generate risk profiles that predict psychological distress among HIV-positive and HIV-negative populations and to use these profiles to guide thematic development for LAPSI, ensuring confidentiality and informed consent.

Methods

The study aims to leverage machine learning algorithms such as Logistic Regression and Random Forest to generate risk profiles and to analyze demographic, socio-economic, and psychological factors, including HIV status, age, education, and employment. Introducing a novel application of machine learning in the identification of psychological distress risk factors for intervention development while adhering to ethical standards for handling sensitive data like HIV status. Prior to data collection, ethical approval will be obtained, ensuring participant confidentiality and informed consent. Themes generated from the risk profiles will inform song selection and peer support intervention for LAPSI.

Results

The machine learning models are expected to highlight education, employment status, and marital status as critical predictors of psychological distress. Geographical and demographic variables, such as district and age, are hypothesized to play a significant role in predicting distress among both HIV-positive and HIV-negative cohorts.

Conclusion

This study posits that machine learning models will provide actionable insights into predicting psychological distress, enabling targeted interventions through LAPSI. This short communication argues for integrating LAPSI into health policies and calls upon health policy actors to recognize its potential in addressing the mental health crisis in Sub-Saharan Africa, advocating for partnerships with local communities, healthcare providers, and mental health advocates to tailor and implement this intervention effectively.
Niosomes: A Revolutionary Approach for Skin Cancer Treatment
Authors: Padave Aditi P. , Rane Bhushan R. , Jain Ashish S.
Published: January 2025

Skin cancer is one of the most common types of cancer globally, with melanoma and
non-melanoma being the two primary forms. Melanoma tends to be less frequent but more dangerous, while non-melanoma types, including squamous and basal cell carcinoma, are more prevalent. Caucasian populations are at a higher risk of developing skin cancer due to their skin's susceptibility to ultraviolet (UV) radiation. According to recent data, skin cancer ranks as the seventeenth most common cancer worldwide. An emerging approach to treating skin conditions, including skin cancer, is using niosomes, an advanced drug delivery system. Niosomes are vesicles
made from non-ionic surfactants, stabilized by cholesterol, that encapsulate drugs. They have
gained prominence because they address several issues related to traditional topical treatments,
such as poor solubility, instability, low bioavailability, and rapid drug breakdown. This review article focuses on the use of niosomes in dermatology, particularly for drug delivery through the skin.
Niosomes offer several distinct advantages, making them an ideal choice for topical drug delivery.
Their unique structure allows them to transport both water-soluble and fat-soluble drugs effectively. Additionally, they enhance drug permeation through the skin, improve drug stability, and allow
for extended drug release. These properties make niosomes a valuable tool in clinical settings, providing potential benefits for a range of skin-related therapies. With their growing popularity, niosomes are shaping the future of innovative and more efficient topical drug delivery methods.
Corporality: From Commonality to Structurality
Authors: Koss Andrey
Published: January 2025

The article conducts a philosophical and ethical investigation into the interaction between human corporeality and the technologies that transform it. As the focus on these technologies shifts, the understanding of the model of corporeality changes as well. An analysis of historical teachings about the essence of corporeality and its structural components is carried out, allowing for the determination of the limits of changes that do not distort human nature. The relationship between corporeality and spirituality in various philosophical traditions and spiritual practices is also examined. The contribution of Rene Descartes to the doctrine of corporeality is highlighted, as he approached this duality from a new perspective, using analytical methods to identify patterns in the existence of the bodily and the spiritual. He concluded that matter has the property of divisibility, while spirituality is indivisible. Corporeality has structural elements, whereas the spiritual does not possess such characteristics, which allowed for a reevaluation of corporeality and the application of a new methodology for study. Over time, structurality began to transform into functionality as an expression of corporeality. This led to the formation of doctrines, one of which viewed humans as functioning soulless machines (block-functional model), while another approach contributed to the emergence of cellular theory (ontogenetic-epistemological), as one of the key directions in the study of human corporeality.

The article examines the views on corporeality of Plato and Aristotle, focusing on their interpretation of the model of the immortality of the soul after physical death. It reveals the connections between body and spirit in the models of G.-W.-F. Hegel (the concept of interiorization) and F.-W. Nietzsche (the formation of the soul). The perspectives on corporeality by J. Baudrillard ("differentiated prosthesis", "matrix of simulation", "body as an object of fetishization") and the socio-cultural constructions of corporeality in the teachings of J.-P. Sartre, E.-G.-A. Husserl, and M. Merleau-Ponty are also discussed. Additionally, a philosophical analysis of the understanding of immortality is conducted. The article examines the influence of neuroscience on cognitive activity and bodily experiences, the expansion of embodiment beyond the physical body, CRISPR technologies, and the impact of virtual reality on existentialism.