bluuebunny/crossref_metadata_2025 huggingface dataset:
Ionic Association of Potassium and Tetrabutylammonium Thiocyanate Salts in Binary
Mixtures of γ-Butyrolactone and N,N-Dimethylacetamide at 298.15 K and 308.15 K
Authors: Kumar Suresh , Anand Hardeep
Published: September 2022

Solvation consequences of potassium thiocyanate (KSCN) and tetrabutylammonium thiocyanate
(Bu4NSCN) in γ-butyrolactone (GBL), N,N-dimethylacetamide (DMA) and their binary mixtures in
concentration range (0.01-0.001) mol Kg–1 of 0, 25, 50, 60, 80 and 100 mol% DMA at T = 298.15 K
and 308.15 K have been studied using conductometric study and some samples of KSCN in GBL +
DMA binary mixtures of different electrolytic concentrations at ambient conditions studied by FTIR
spectroscopic methods. The Shedlovsky equation has been used to elucidate the data in terms of the
limiting molar conductances (Λo), ion-pair association constants (KA). The Walden products (Λoηo),
solvated radii (ri) and standard free energies of association (ΔGºA) were further evaluated in terms of
solvation of ions. The reference electrolyte tetrabutylammonium tetraphenylborate (Bu4NBPh4) was
used to determine the limiting molar ionic conductances. In pure solvents and their binary mixtures,
electrolytes showed a strong association. The K+ ions have greater solvation in GBL than in DMA
observed on basis of solvated radii in GBL + DMA binary solvent mixtures at both experimental
temperatures. The study demonstrates that the ion-solvent interactions decrease on enhancing the
temperature. The FTIR analysis was applied to obtain information about molecular as well as ionic
association of KSCN in GBL + DMA binary mixtures at the ambient conditions, which has provided
the information on structuring infrared modes of vibrational stretching frequencies according to the
nature of the solvents or the cations. Shifting of vibrational frequencies of several functional groups of
DMA and GBL in binary mixed solvents has been observed in terms of ion-ion, ion-solvent and
solvent-solvent interactions.
Brewing Nanochemistry with Green Tea: A Review with Sustainable Approaches
Authors: Gupta Ashu , Monga Yukti , Rana Pooja , Mittal Sachin , Kumar Vinod , Sharma Rakesh K.
Published: September 2022

The growth of the “green chemistry” has brought to the society a new prospects and broader picture of
what mankind can achieve through sustainable manipulation at the chemical scale. Why nature is so
important to human being and we must protect our environment. Nature preservation could be achieved
by opting the fundamental concepts underlying the principles of green and sustainable chemistry. The
use as well as generation of unwanted or harmful byproducts must be avoided by adopting simple,
safer and authentic synthesis methodologies. To attain this goal, utilization of natural ecofriendly
systems is highly crucial and desired. Among the available physical, chemical and other biogenic
green procedures of fabrication for various metal-based nanoparticles, green tea extract application is
relatively simple, quick in approach and safer way to generate these nanoparticles. In present review,
the different reported metal nanoparticles synthetic methods using green tea is collectively emphasized.
The literature precedents using mentioned reports has already been proved themselves cost effective,
efficient and eco-friendly alternative for generating metal nanoparticles. Present work also provides
the reported applications of generated nanoparticles, which are prepared by this benign procedure.
Facile Synthesis, Analysis of Physico-Chemical Properties and
Tape Casting of Al2O3 Nanoparticles
Authors: Deepi Alagu Segar , Priya Srinivasan Dharani , Freeda Christy Clementz Edwardraj , Nesaraj Arputharaj Samson
Published: September 2022

Alumina (Al2O3) powder was synthesized by simple wet-chemical precipitation method. The phase
study was done using XRD confirming the FCC phase. FTIR showed the presence of Al-O vibrations.
Particle size analysis (PSA) confirmed the presence of particles in the range of 300 nm. The EDX
confirmed the presence of Al and O elements in the samples only and no impurity elements. SEM
exhibited the ultrafine nature of the particles. The tape casting of Al2O3 nanoparticles was carried out
with suitable organic ingredients. Based on the trials, the best composition for alumina tape casting
was optimized. The SEM of green alumina thin sheet resulted in good surface behaviour. Optimized
composition may be used for fabricating thin Al2O3 based electrical components for application in
electronics industry.
Comparative Assessment of Seasonal Variation in
Size-Segregated Particulate Matters around Urban Drains
Authors: Jamloki Asha , Ranjan Anuj , Chauhan Abhishek , Tyagi S.K. , Jindal Tanu
Published: September 2022

The rapidly growing urbanization has resulted in increased environmental pollution and degradation
that has equally affected the quality of air and wastewater. Urban drains that carry wastewater from
households and industries are also carrying loads of pollutants. The current study was conducted to
compare the trend in the concentration of particulate matter (PM) in the air, across the seasons near the
urban drains in Delhi, a metropolitan city. The air samples were taken from Najafgarh drain, which is
the biggest drain of Delhi city and has a contribution of about 60% of the total wastewater released
from Delhi city into river Yamuna. The Indian Standard method IS 5182 Part 24:2019 was used for
PM2.5 & IS 5182 Part 23:2006 was used for PM10 monitoring and analysis. The results of the analysis
showed that the variation in particulate matter (PM) is observed with changes in relative humidity and
with seasonal changes. The variation in PM2.5 levels was seen in a range of 55.30-118.42 μg/m3 from
June 2020 to February 2021 & in PM10 levels were seen in the range of 77.54-261.99 μg/m3 during
June 2020 to February 2021 for location L1. The variation in PM2.5 levels was seen in a range of
23.84-76.94 μg/m3 from June 2020 to February 2021 & in PM10 levels were seen in the range of
42.06-149.48 μg/m3 during June 2020 to February 2021 for location L2. Few studies have shown that
contaminants can enter into the fresh air from the municipal wastewaters and open drains.
Admicellar Polymerization of Tris(2-acryloyloxyethyl)phosphate on
Cotton Fabric for Flame Retardant Finishing
Authors: Dinesh  , Dahiya J.B.
Published: September 2022

To improve the flame retardant property, the admicellar polymerization process was applied to
polymerize and coat the tris(2-acryl-oyloxyethyl)phosphate (PTAP) monomer on cotton fabric (CF).
The polymerization was completed with the support of a cationic surfactant cetyltrimethylammonium
bromide (CTAB) and an initiator 2,2′-azobisisobutyronitrile (AIBN). Thermogravimetric analysis
(TGA) and limiting oxygen index test (LOI) were performed to find out the effects on degradation and
flammability of modified cotton fabric. One of the modified cotton fabric samples (CF-PTAP) show
the decrease in onset temperature caused by acid catalyzed dehydration released from PTAP polymer
placed on cotton fabric substrate. The increase in char yield (20.9%) and LOI value (25.0% demonstrated
a condensed phase flame retardant action) owing to the presence of PTAP polymer on substrate.
Development and Validation of Novel RP-HPLC Method for Determination of
Assay and Related Substances of Flucytosine in Drug Product
Authors: Saravanan R. , Somanathan T.
Published: September 2022

A novel, rapid, simple and cost-effective RP-HPLC method was developed for the assay of flucytosine
and its related substances in drug product (tablets). The developed method was subjected to validation
challenges as per the ICH guidelines and the method found to follow all the validation challenges
successfully. Method employed uses a column with L1 end-capped stationary phase having dimensions
of 250 mm × 4.6 mm, 5 μm. The mobile phase comprised of 10 mM phosphate buffer and methanol in
gradient mode. The detection was performed at 210 nm. The flucytosine peak eluted at about 5.5 min
making the method cost-effective. In this method, the related substances were also quantified. Owing
to short run time, simple chromatographic conditions and sample preparation, the method is claimed
to be ideal for the routine high throughput analysis leading to low cost of testing.
A New Stability Indicating Reverse Phase HPLC Method for the
Determination of Related Substances of DPP4 Inhibitor Drug: Linagliptin
Authors: Salapaka Appalacharyulu , Bonige Kishore Babu , Reddy K. Chandrasekhar , Sharma Hemant Kumar , Ray Uttam Kumar
Published: September 2022

A simple, sensitive, selective and reproducible stability indicating reverse phase HPLC method has
been developed and validated for the determination of related substances of linagliptin drug substance.
Separation of impurities was carried out on a YMC Pack ODS-AQ, 5 μm (250 × 4.6 mm) column.
Column eluent consists of gradient mixing of phosphate buffer at pH-3.7 as mobile phase A and a
mixture of acetonitrile, methanol and water in the ratio of 600:250:150 v/v/v as mobile phase-B.
Gradient elution at a flow rate of 1.0 mL/min and injection volume is 10 μL. The UV/vis detector is set
to a wavelength of 226 nm and the column oven is set at 30 ºC. The detector response was found to be
linear over the concentration range of 0.07-1.1 μg/mL with correlation coefficients greater than 0.999
for linagliptin and its related substances. LOD values for specified impurities range from 0.004-0.005%
w/w and LOQ values from 0.013-0.015% w/w. The accuracy obtained by the proposed method was
found to be in the range of 93.2-101.3%. Degraded and process impurities are well separated and the
method has been validated for specificity, precision, ruggedness, linearity, accuracy and robustness as
per ICH guidelines.
Antibiofilm, Cytotoxicity and Release Studies of Green Synthesized ZnO Nanoparticles
Embedded in Poly(Methyl Methacrylate) in Management of Cariogenic Streptococcus mutans
Authors: Ahalya N. , Dhamodhar P. , Sanmati N. , Krishnakumar Aditya
Published: September 2022

Nanoparticles exhibiting microbicidal and antibiofilm activity against Streptococcus mutans seems to
be a promising prospect in the management of dental caries. In present study, zinc oxide nanoparticles
were synthesized using Rosa bracteata extract and characterized using UV visible spectroscopy, SEM
and XRD. The synthesized ZnO nanoparticles exhibited a strong absorbance at 390 nm, with an
average crystalline size of 118 nm. The SEM analysis showed nanowire like structures with a size
ranging between 65-150 nm. The ZnO nanoparticles exhibited antibacterial activity against
Streptococcus mutans at a concentration of 100 μg/mL. There was a significant reduction in the number
of S. mutans forming biofilm, in the presence 100 μg/mL of ZnO nanoparticles. Further, ZnO
nanoparticles were embedded in the dental prosthetic material poly(methyl methacrylate) to form
PMMA-ZnO nanocomposites and the amount of ZnO nanoparticles released from the nanocomposite
was measured. Further, the ZnO nanoparticles at 100 μg/mL concentration were found to be non-toxic
on the HaCaT cell lines. This study proves that the green synthesized ZnO nanoparticles incorporated
into the dental prosthetics can be used in the control and prevention of secondary dental caries.
Anodization of Aluminium Alloys in Hydrofluoric Acid and Sulfuric Acid for Space Applications
Authors: Somasundaram Soniya , Krishna P. Murali
Published: September 2022

Present work demonstrated the development of a typical solar reflector coating by optimizing the bath
parameters for an anodizing process on aluminium 2024 alloy. This evidently explains the pre-cleaning
as well as optimization of the bath parameters for the development of solar reflector anodic film on
aluminium alloys. The electrolytic bath for anodization consists of concentrated sulphuric acid and
hydrofluoric acid. The anodization parameters such as solution temperature, process time and current
density were optimized in order to achieve an anodic film of 10-12 μm thickness on the aluminium
surface based on α/ε ratio, [solar absorbance (α) and thermal emittance (ε)] with a low solar absorbance
(< 0.20) and high thermal emittance (> 0.80). The chemical analysis of the surface coating has been
done by energy dispersive X-ray spectroscopy (EDS) and microstructure analysis by scanning electron
microscopy (SEM). The finalized anodic film was compared with the sulphuric acid and chromic acid
anodized surface. The average breakdown voltage of the solar reflector specimens coating was 355 V,
which is higher than sulphuric acid anodized and chromic acid anodized samples.
Validación del Cuestionario de Climas Motivacionales empowering y disempowering en jóvenes deportistas mexicanos
Authors:   Universidad Estatal de Sonora, Sonora, México, Gutiérrez García Pablo , Castillo Jiménez Nallely ,   Universidad Autónoma de Nuevo León, Nuevo León, México, Tristán José ,   Universidad Autónoma de Nuevo León, Nuevo León, México, López-Walle Jeanette M. ,   Universidad Autónoma de Nuevo León, Nuevo León, México, Balaguer Isabel ,   Universidad de Valencia, Valencia, España, Coronel Pérez Francisco Javier ,   Universidad Autónoma del Occidente, Sinaloa, México
Published: September 2022

Introducción: El objetivo del estudio fue validar el Cuestionario de Climas Motivacionales Empowering y Disempowering (Empowering and Disempowering Motivational Climate Questionnaire-Coach, EDMCQ-C) en jóvenes deportistas mexicanos a través del análisis de sus propiedades psicométricas, fiabilidad, validez convergente-discriminante, concurrente y factorial (de primero y segundo orden). Método: Participaron un total de 1243 jóvenes deportistas mexicanos de 12 a 17 años. Resultados: Los análisis mostraron adecuadas propiedades psicométricas, tanto de fiabilidad por dimensiones y factores, como de validez, convergente-discriminante, concurrente, factorial, de dos dimensiones (AFC de primer orden) y de cinco factores con sus respectivas dos dimensiones (AFC de segundo orden). Conclusión: Estos datos sugieren que la versión adaptada al contexto mexicano es un instrumento válido y fiable para evaluar la percepción de los climas motivacionales que generan los entrenadores en jóvenes deportistas mexicanos.
Editing Otherwise
Authors: Nabugodi Mathelinda
Published: September 2022

In her important book, In the Wake: On Blackness and Being (2016), Christina Sharpe encourages Black scholars to “imagine otherwise” in order to do justice to the painful legacies contained in the archive. In this provocation, I consider the ramifications that Sharpe’s argument might have for editorial scholarship and finish with an invitation to re-examine the boundary between editing and adaptation.
Editing and Curating Online
Authors: McGann Jerome
Published: September 2022

The complexity of natural language works, especially transinformational works, cannot be adequately represented by what has become the institutional standard for DH editorial projects, TEI. In that respect book technologies remain far superior to current digital tools in sustaining their reciprocal communicative action. Recent developments in graph database platforms suggest ways to accommodate the n-dimensionality of such work to the disambiguating inertia of digital tools.
“the answer, as well as a technique”
Authors: Griffiths Matthew
Published: September 2022

This article explores the way that the practices of copy-editing technical journals, composing poetry, and ecocritical research can complement one another, drawing on individual professional, creative, and academic experience. It reports on an exercise devised to generate material for a poem by collating edits from technical copy, and works through this to compose a piece based on the UK government’s 2018 environment plan. Critical reflections are then offered on the resultant text and the value of the process, with some proposals for further application.
Editing in the Bath
Authors: Schad John
Published: September 2022

The relationship between authorial intention and the work of textual editing is often vexed, particularly if the author does not themselves intend to be published at all. Cue Gerard Manley Hopkins. In Hopkins’ case, though, things become still more complex when we attend to the fact that the only person who is said ever to have desired, or intended, that Hopkins be published may not really have existed. Or, if he did exist, he may well have been someone who ended his life in a bath, in Oxford, in 1929.
Version and Document
Authors: Bryant John
Published: September 2022

I have two provocations to share: one theoretical, having to do with the revision text of Moby-Dick; the other practical, having to do with visualizing versions in the editing of Billy Budd. Both are rooted in the material and yet digital; both engage readers in creative interpretations of revision.
Breakthrough Cancer Pain: The Current Pharmacological Management
Authors: Mochamat Mochamat , Nugroho Taufik Eko , Wicaksono Satrio Adi
Published: September 2022

Background: Breakthrough pain (BTP) is a transient increase in pain that occurs on a background of stable pain. It contributes substantially to the suffering experienced by most cancer patients. The pharmacologic options for management of BTP have been expanded considerably in the past decade. Opioids remain the most effective pharmaceuticals used for the BTP case. In this systematic review we attempted to provide the currently available clinical data about pharmacological treatment for breakthrough cancer pain.Objective: To evaluate the efficacy of pharmacological treatments for Breakthrough painMethods: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) and PubMed for the last ten years (from September 2010 to September 2020. Further potentially relevant studies were identified from reference lists of studies marked for inclusion and relevant reviews. Two review authors independently assessed trial quality and extracted data. We screened the search results and included studies if they met the selection criteria.Result: We screened 205 publications of which 14 met the inclusion criteria. In total, we analysed data from 2129 participants. Overall, participant with BTP were treated with short acting opioid. Literature searching did not find any published evidence of non opioid drug to treat the BTP. Most adverse effects of the investigated drugs seemed to be moderate.Conclusion: The findings of this review suggest that rapid onset opioids play significant role for BTP. Future studies may be conducted to explore the efficacy and safety profiles each regimen for patients with certain categories of cancer.
Perbandingan Pengaruh Pemberian Ketamin 0,1 mg/KgBB dan Parasetamol 1000 mg Secara Intravena Terhadap Kadar Interleukin-6 pada Pasien Pasca Lower Limb Orthopedic Surgery
Authors: Nugroho Taufik Eko , Setionegoro Adi Sakti , Primatika Aria Dian , Wicaksono Satrio Adi
Published: September 2022

Latar Belakang: Lower limb orthopedic surgery merupakan tindakan bedah ortopedik pada ekstremitas inferior yang meliputi tulang, sendi, dan vaskular. Peningkatan interleukin-6 (IL-6) sistemik setelah pembedahan meningkatkan morbiditas dan mortalitas pascaoperasi. Sebagai analgesik, ketamin dan parasetamol mempengaruhi ekspresi IL-6.Tujuan: Penelitian ini adalah untuk membandingkan pengaruh pemberian ketamin 0,1mg/Kg IV dengan parasetamol 1000 mg IV terhadap kadar IL-6 pada pasien pasca lower limb orthopedic surgery yang mendapatkan regional anestesi.Metode: Penelitian ini menggunakan randomized control trial pada 54 pasien yang telah menjalani lower limb orthopaedic surgery dan memenuhi kriteria inklusi dan eksklusi. Sampel dibagi menjadi 3 kelompok yang terdiri dari kontrol (K); epidural bupivakain 0,125%, perlakuan 1 (P1); dengan tambahan ketamin 0,1 mg/KgBB IV dan perlakuan 2 (P2); dengan tambahan parasetamol 1000 mg IV pascaoperasi. Sampel darah diambil 2 jam pascaoperasi untuk diukur kadar IL-6 menggunakan metode enzyme linked immunosorbent assay (ELISA).Hasil: Penelitian ini menghasilan nilai rerata IL-6 kelompok K = 72,22±66,93 pg/ml; P1 = 7,18±4,18 pg/ml dan P2 = 7,00±2,92 pg/ml. Uji Kruskal Wallis menunjukkan nilai signifikan (p=0,000). Hasil penelitian menunjukkan nilai signifikan pada K terhadap P1 (p=0,000) dan K terhadap P2 (p=0,000), sedangkan P1 terhadap P2 tidak signifikan (p=0,438).Kesimpulan: Pemberian ketamin atau parasetamol pasca lower limb orthopaedic surgery secara signifikan menurunkan kadar IL-6. Tidak ada perbedaan antara ketamin dan parasetamol dalam menurunkan kadar IL-6 pascaoperasi lower limb orthopedic surgery.
Eko-Terörizm Kavramı Üzerine Bir Tartışma: Yeryüzü Kurtuluş Cephesi ve Hayvan Kurtuluş Cephesi’nin Analizi
Authors: Genç Yılmaz Ayfer
Published: September 2022

11 Eylül’ün ardından, terörizm tüm dünyayı ilgilendiren bir mesele haline gelmiştir. O günden sonra, bir hayli tartışmalı bu kavramı yeniden tanımlamaya yönelik hem akademik hem de popüler tartışmalar ortaya çıkmıştır. Bir taraftan, siyasal otoriteler ve genel olarak güvenlik kurumları kavramın anlamını genişletmeye başlarken, diğer taraftan çok sayıda araştırmacı temel hak ve özgürlüklerin istismarını engellemek amacıyla terörizm kavramının sınırlarını çizmek ve ona belirli ve nesnel bir tanım vermek için çaba sarf etmiştir. Bu süreçte, uluslararası terörizmin yükselişine yönelik artan ilgiyi rağmen, diğer taraftan, ABD’de bir başka terörizm türünün -yerel terörizm- kendini göstermiş ve beraberinde tartışmaları tetiklemiştir. 2000’li yıllarda FBI ekolojik terörizmi ABD için en önemli tehlike olarak gördüğünü açıklamıştır. Bu çalışma, bir ekolojik örgütlenme olarak Dünya Kurtuluş Cephesi ve hayvan hakları örgütlenmesi olarak Hayvan Kurtuluş Cephesi’nin stratejileri ve kundaklama ve genel olarak mülkiyeti yok etmeye yönelik faaliyetlerini incelemek suretiyle bu örgütlenmelerin terörist olarak sınıflandırılıp sınıflandırılamayacağını tartışmak niyetindedir. Bu tartışmayı yürütebilmek için Ganor’ıun siillere ve sivil hedeflere zarar vermeye odalanan terörizm tanımını kullanacaktır. Eko-terörizm üzerine yapılacak tartışma üzerinden, çalışma, Ganor’ın terörizm tanımının eksik ve yetersiz yanlarını ortaya koyacak ve daha iyi yapılandırılmış bir terörizm tanımı sağlamak amacıyla gerekli kriterleri göstermeye çalışacaktır.
“Sürgünde Muhalefet, Namık Kemal’in Hürriyet Gazetesi” Işığında Avrupa’nın Doğu Siyaseti Tasavvurunda Oryantalizmin Tezahürü
Authors: Akkaya Sacide Nur
Published: September 2022

19. yüzyılın ikinci yarısından itibaren hız kazanan kolonizasyon faaliyetleri neticesinde Avrupalı devletler; Afrika, Doğu ve Asya üzerinde bir sömürgecilik yarışına girişmiş ve bu bağlamda, Osmanlı İmparatorluğu’nun geniş toprakları, bu devletlerin ilgi alanına giren önemli bir coğrafya olarak öne çıkmıştır. Çeşitli modernleşme faaliyetinin gerçekleştirildiği ve siyasi dengenin düzeltilmesi için ciddi gayretlerin sarf edildiği bu dönemde Osmanlı devleti aydınları, basın yolu ile ifade ettikleri düşüncelerle düzenin iyileştirilmesi ve devlet yapısının tekrar güç kazanması yolunda önemli bir çaba göstermiştir. Bu bakımdan, Yeni Osmanlılar’ın Avrupa’da sürgünde iken yayınladıkları Hürriyet gazetesi, hem dönemin güncel siyasi tarihine ışık tutan bilgiler içermesi hem de Avrupa’nın Doğu politikasına dair detayları yansıtması bakımından önemli bir kaynak konumundadır. Bu gazetedeki makalelerden derlenen verilerden hareketle hazırlanan bu çalışmada, Avrupalı devletlerin Doğu coğrafyasına yönelik politik yaklaşımları incelenmiş ve bu bağlamda, bölge için geliştirdikleri siyasi tasavvur içerisindeki oryantalizm kavramını ilgilendiren unsurlara ışık tutulmaya çalışılmıştır. İkinci ve üçüncü bölümlerde, Yeni Osmanlılar, Hürriyet gazetesi ve Avrupa’nın Doğu siyaseti çerçevesinde yüzyıllar içerisinde gelişen oryantalizm politikası hakkında genel bilgi verilmiştir. Çalışmanın asıl kısmını oluşturulan dördüncü bölümde, Hürriyet gazetesindeki veriler ışığında Avrupa’nın Doğu siyaseti tasavvurunda oryantalizm politikasının görünürlüğü, belirli bir çerçeve etrafında ele alınmıştır.
The End of Open Society Realism?
Authors: Schuett Robert
Published: September 2022

Does the ‘Zeitenwende’ herald the beginning of a new and as yet undefined open society realism? The present essay argues this question requires critical discussion of nature and value of realist political theory, particularly at a time where international society is accelerating to somewhere which is itself as yet unclear. Adding to revisionist research on political realism in International Relations (IR) theory I sketch how a political vision I call open society realism may be developed out of Classical realism, in sharp distinction to academic IR neorealism for methodological and political reasons. To strip foreign policy realism from Continental philosophy, law, and history risks that we become what political liberalism ought to avoid: a closed society with a good conscience retreating from world politics, hiding behind the ‘national’ interest as if strategic great power management is a methodic function of structure rather than the politics of an ethically conscious diplomacy.
Long non-coding RNA NEAT1 promotes angiogenesis in hepatoma carcinoma via the miR-125a-5p/VEGF pathway
Authors: Guo Jingyun , Yuan Qi , Fang Yuan , Liao Jinmao , Zhang Zheng
Published: September 2022

The study’s purpose was to investigate the biological function of long non-coding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) in hepatoma carcinoma (HCC). HCC tissues and cells exhibited increased levels of NEAT1 and decreased levels of miR-125a-5p. Reduction in the expression of NEAT suppressed HepG2 cell proliferation and increased apoptosis. This was accompanied by suppression of the AKT/mTOR and ERK pathways, while the opposite was observed for miR-125a-5p. Angiogenesis assay results indicated that NEAT was proangiogenic. A dual-luciferase reporter assay indicated that NEAT1 was bound to miR-125a-5p and miR-125a-5p was bound to vascular endothelial growth factor (VEGF). The proangiogenic effects of NEAT and its stimulation of AKT/mTOR and ERK were reversed by miR-125a-5p. The anti-angiogenic effects of miR-125a-5p and its inhibitory effect on AKT/mTOR and ERK pathways were reversed by co-incubation with VEGF. The conclusion was that NEAT1 enhances angiogenesis in HCC by VEGF via a competing endogenous RNA (ceRNA) of miR-125a-5p that regulates AKT/mTOR and ERK pathways.
Pediatric reference interval verification for 17 specialized immunoassays and cancer markers on the Abbott Alinity i system in the CALIPER cohort of healthy children and adolescents
Authors: Bohn Mary Kathryn , Wilson Siobhan , Schneider Randal , Massamiri Youssef , Randell Edward W. , Adeli Khosrow
Published: September 2022

Objectives

Clinical laboratory investigation of autoimmune, metabolic, and oncologic disorders in children and adolescents relies on appropriateness of reference intervals (RIs). The Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) previously established comprehensive pediatric RIs for specialized immunoassays on the Abbott ARCHITECT system. Herein, we aim to verify performance on new Alinity i assays by evaluating sera collected from healthy children as per Clinical and Laboratory Standards Institute (CLSI) EP-28A3C guidelines.

Methods

Precision, linearity, and method comparison experiments were completed for 17 specialized Alinity immunoassays, including cancer antigens, autoimmune peptides, and hormones. Sera collected from healthy children and adolescents (birth-18 years, n=100) were evaluated. CLSI-based verification was completed using previously established CALIPER RIs for ARCHITECT assays as the reference.

Results

Of 17 specialized immunoassays assays, only anti-cyclic citrullinated peptides (anti-CCP) did not meet acceptable verification criterion (i.e., ≥90% of results within ARCHITECT reference CI). Anti-thyroglobulin, anti-thyroid peroxidase, and carcinoembryonic antigen did not require age-specific consideration beyond one year of age, with 63, 91, and 80% of samples equalling the limit of detection, respectively. Estimates were separated by sex for relevant assays (e.g., sex hormone binding globulin, total and free prostate specific antigen).

Conclusions

Findings support transferability of pediatric RIs on ARCHITECT system to the Alinity system for 16 specialized immunoassays in the CALIPER cohort and will be a useful resource for pediatric clinical laboratories using Alinity assays. Further work is needed to establish evidence-based interpretative recommendations for anti-CCP and continue to evaluate pediatric RI acceptability for newly available assay technologies.
Supporting the transition to practice: preceptor behaviors that foster a positive student preceptorship experience
Authors: Flott Elizabeth , Ball Sarah , Manz Julie , Beiermann Trisha , Khanna Maya M.
Published: September 2022

Objectives

Preceptors support nursing students when transitioning to the professional nursing role. This study explored student perceptions of preceptor characteristics that promoted or hindered learning.

Methods

A Likert-scale survey including two open-ended questions was sent to 571 nursing students completing a preceptorship experience. Descriptive statistics were used to analyze responses to the Likert-scale items. Qualitative analysis was completed on the two exploratory questions to extract themes.

Results

Students rated the preceptor between 4=Very Good and 5=Outstanding for all items. No significant differences in scores were found when comparing results between programs. Themes assisting in learning included: increasing independence gradually and pushing out of comfort zone. Themes identified that hindered learning included: doubting self and being pushed aside.

Conclusions

Future implications include communicating preceptorship objectives and providing ways to apply research to practice. These findings can guide collaboration between academic and practice partners to assist with transition to practice.
Does the pandemic hamper or boost the necessity for an international language? A survey on English use frequency among Japanese workers
Authors: Terasawa Takunori
Published: September 2022

This study aims to reveal the impact of the COVID-19 pandemic on the necessity of using English as an international language. For this purpose, this study conducted a web survey of Japanese workers, and statistically examined the extent to which the use of English increased or decreased after the outbreak. The findings are as follows. First, although some types of use decreased or increased, the majority did not show substantial changes. Second, the changes in English use were largely influenced by worker factors, such as types of occupation and employment (e.g. it declined typically among sales workers but not among the self-employed and freelancers), the degree of remote working (e.g. not being allowed to work remotely reduced it), and industry (e.g. it declined among workers in accommodation and real estate sectors but increased among public servants). These findings suggest the following implications: (1) non-decline in English use would suggest its resilience as an international language, the necessity of which could endure even in such a global upheaval; and (2) the frequency of using English (and other modes of international communication) is relatively independent of reduced human mobility, but it is largely affected by the economic climate.
Die Digitalisierung der Pressedokumentation beim Deutschen Bundestag – Ein problemorientierter Rückblick (Teil 1)
Authors: Sator Klaus
Published: September 2022

In der Pressedokumentation beim Deutschen Bundestag wurde in Zusammenhang mit dem Umzug des deutschen Parlaments von Bonn nach Berlin im Jahr 1999 ein elektronisches Produktions-, Rechercheund Archivsystem eingeführt. In einem problemorientierten Rückblick werden die damit verbundenen Veränderungen in Beziehung gesetzt zu den an seine Einführung geknüpften Zielen und Erwartungen. In diesem ersten Teil des Beitrags steht die technische Seite der Digitalisierung des Pressearchivs im Vordergrund. Sie veränderte die Arbeitsabläufe und eröffnete Chancen für neue Informationsdienstleistungen der Pressedokumentation. Die damit einhergehenden lizenz- und presserechtlichen Veränderungen haben Auswirkungen auf die Bestandsbildung.
Can Causal Powers Cause Their Effects?
Authors: Raimondi Andrea
Published: September 2022

Causal Dispositionalism provides an account of causation based on an ontology of causal powers, properties with causal essence. According to the account, causation can be analysed in terms of the interaction of powers and its subsequent production of their effect. Recently, Baltimore, J. A. (2022. “Dispositionalism, Causation, and the Interaction Gap.”Erkenntnis87: 677–92) has raised a challenge against two competing approaches, the compositional view (CV) and the mutual manifestation view (MMV), to explain what makes powers interactive –the interaction gap. In this paper, we raise the challenge of explaining what makes powers productive –the production gap. While Baltimore’s verdict is tentatively favouring (MMV), we find both approaches wanting. Our conclusion is that Causal Dispositionalists should take Baltimore’s and our critique seriously. Powers cannot cause their effects just by bearing the name “causal”. To deserve their names, more metaphysical details are needed.
Hesitant versus confident family language policy: a case of two single-parent families in Finland
Authors: Vorobeva Polina
Published: September 2022

During the past decade, the field of family language policy has broadened its scope and turned its attention to diverse family configurations in versatile sociolinguistic contexts. The current study contributes to this endeavor by focusing on two single-parent families who live in Finland and who strive to support Russian as a family language. Applying nexus analysis as an epistemological stance and as an analytical lens, the study takes an emic perspective on family language policy. Furthermore, it examines how family language policy is manifested and negotiated during mother–child play and what discourses shape it. The findings reveal two contrasting ways in which family language policy is manifested and negotiated in the families. Confident family language policy in one of the families is informed by the mother’s historical body (i.e., prior experience of raising children bilingually), while in the other family, discourse in place represented by divergent language ideologies plays a significant role in shaping family language policy and is connected with hesitant decisions about language use in the family.
The crystal structure of 5-azido-1-methyl-4-nitroimidazole, C4H4O2N6
Authors: Huipeng Zhao , Pengbao Lian , Cai Cao , LiZhen Chen , Jianlong Wang
Published: September 2022

C4H4O2N6, monoclinic, P21/c (no. 14), a = 11.633(3) Å, b = 8.899(3) Å, c = 6.7638(18) Å, β = 105.216(12)°, V = 675.6(4) Å3, Z = 4, Rgt
(F) = 0.0607, wRref
(F
2) = 0.1617, T = 170 K.
Discerning users of information: A qualitative analysis of student inquiry
Authors: Krueger Karla Steege , Taylor Joan Bessman
Published: September 2022

School Librarians are poised to lead a shift in information and digital literacy instruction with a growing emphasis on the evaluation of information sources, a need precipitated by widespread societal sharing of mis- and disinformation. What does the inquiry learning process look like when a team of students creates an innovative solution to a problem they identified through project-based research? And does such research enable students to practice the skills necessary to be discerning across information contexts? The information literacy instruction woven throughout the project contributed to the visible successes in student inquiry-based learning. And the skills necessary to be a discerning user of information were enabled through inquiry-based learning and would benefit from collaborative librarian instruction. Implications for school librarians point to teaching components from this project that are recommended for similar units (project scenario, process rubric, librarian background research packet, time to do research, librarian-led group discussion of focus, teacher prompts, teacher and mentor arranging expert visits, and a panel of judges) and those needed for future collaboration (scaffolding for searching for and tracking relevant sources, teaching complex note taking to decipher credible authors and sources, categorizing notes and sources by points of view, and citing sources to corroborate evidence).
Jointly Rayleigh lifetime products in the presence of competing risks model
Authors: Badr Souha K. , Abu-Zinadah Hanaa
Published: September 2022

In this article, we are applying the competing risks model of product from two different lines of production. So, the comparative life test is done under type-II censoring scheme with consideration of only two independent causes of failure. The statistical analysis procedures are developed considering joint sample of production and its life distributed with the Rayleigh lifetime distribution. The point estimation and the corresponding asymptotic confidence interval of the model parameters under maximum likelihood are constructed. Two bootstrap confidence intervals, bootstrap-

p

p

, and bootstrap-

t

t

, are discussed. Also, Bayesian approach to estimate point and credible interval is constructed. The estimation results are discussed through data set analyses. The validity of theoretical results is assessed and compared through Monte Carlo study. Finally, some of the points are reported as a brief comment.
Introduction: Race and Landscape in Nazi Germany*
Authors: Vollgraff Matthew
Published: September 2022

This article introduces the themes and contributions of this special issue on Art and Environment in the Third Reich. The work of architect and reformer Paul Schultze-Naumburg is examined as a case study of the aestheticization of ‘race’ and landscape from the Wilhelmine Period to the National Socialism, particularly as it bore on German colonization and settlement projects in eastern Europe. Today’s resurgent far right and environmental crisis, it is argued, lend new urgency to critical interrogation of the relationship between environmental politics and the visual representation of nature under fascism. The articles collected in this issue illustrate a range of interdisciplinary approaches that move beyond iconography to address alternative media, materialities, and environmental history.
The Painter Werner Peiner, the Culture of the German Oil Industry, and the Nature of Hitler’s State
Authors: van Dyke James A.
Published: September 2022

This article examines the monumental mosaics, large stained glass windows, and illustrated maps that the German painter Werner Peiner (1897–1984), now best known for his designs for the representative buildings of Hitler’s dictatorship, produced between 1931 and 1935 for Shell Oil and its German subsidiary. The discussion of these commissions, which emerged from Peiner’s social networks of the 1920s and contributed to his career as a state artist after 1933, explains their function as ideological images promoting the interests of a global corporation and affirming modern automotive technology using conservative, mythologizing tropes of paradisical nature, traditional cultural landscapes, and immutable national communities that the painter later employed in his work for Hitler’s state.
Enzyme–substrate interface targeting by imidazole‐based γ‐secretase modulators activates γ‐secretase and stabilizes its interaction withAPP
Authors: Petit Dieter , Hitzenberger Manuel , Koch Matthias , Lismont Sam , Zoltowska Katarzyna Marta , Enzlein Thomas , Hopf Carsten , Zacharias Martin , Chávez‐Gutiérrez Lucía
Published: September 2022

Alzheimer's disease (AD) pathogenesis has been linked to the accumulation of longer, aggregation‐prone amyloid β (Aβ) peptides in the brain. Γ‐secretases generate Aβ peptides from the amyloid precursor protein (APP). Γ‐secretase modulators (GSMs) promote the generation of shorter, less‐amyloidogenic Aβs and have therapeutic potential. However, poorly defined drug–target interactions and mechanisms of action have hampered their therapeutic development. Here, we investigate the interactions between the imidazole‐based GSM and its target γ‐secretase—APP using experimental andin silicoapproaches. We map the GSM binding site to the enzyme–substrate interface, define a drug‐binding mode that is consistent with functional and structural data, and provide molecular insights into the underlying mechanisms of action. In this respect, our analyses show that occupancy of a γ‐secretase (sub)pocket, mediating binding of the modulator's imidazole moiety, is sufficient to trigger allosteric rearrangements in γ‐secretase as well as stabilize enzyme–substrate interactions. Together, these findings may facilitate the rational design of new modulators of γ‐secretase with improved pharmacological properties.
ER exit sites take the strain
Authors: De Matteis Maria Antonietta , Venditti Rossella
Published: September 2022

Cells are able to adapt their growth to external mechanical strain. A recent study by Phuyal et al (2022) has shown that these responses depend on the heterodimerization of two small GTPases.
Deradicalization Through the Encouragement of Pancasila Values Education: Challenges for Indonesia and the International Community
Authors: Al-Hashimi Maulana Akbar , Kristianto Tri Agus , Idrissa Adwin Delio
Published: September 2022

Deradicalisation is every effort to neutralize radical ideals through interdisciplinary approaches, such as law, psychology, religion, economics, education, humanity and socio-culture for those who are influenced or exposed to radical and / or pro-violence. Implementation of Deradicalization Program (Development) can be done through Deradicalization in Prisons with the Target of terrorism prisoners who are in prison by identifying, Rehabilitation, Reeducation and Resosialisation. Deradicalisation has a goal, among other things, to restore the actors involved who have a radical understanding to return to a more moderate mindset. Deradicalisation of terrorism is very important because terrorism has become a serious problem for the international community because at any time it will endanger the national security for the country hence deradicalization program is needed as a formula of prevention and prevention of radical understanding like terrorism.
Between Modernization and Capitalization: Commercialization of Malang in The Early Twentieth Century
Authors: Hudiyanto R Reza
Published: September 2022

Abstract: Â Colonialism, capitalism, and the city are three elements that always correlated.Â At the beginning of the 20th-century cities, growth wasÂ inseparable from the economic expansion of Dutch capitalism represented by theÂ plantation industry, trade offices, insurance offices, and elite shopping areas. The exploitation of urban space followed this process.Â As the regime changed in early 1942, theÂ growth of the symbol of capitalism in the city was halted by the Japanese Military Government.Â This article attempts to explain the relationship between the development of capitalism, the modernization of the city, and its impact on society.Â To explain this connection, the author uses historical methods using the city government report.Â Based on analysis of municipal tax report and the response of indigenous people who lived within the city, it can be concluded that there is an influence of capitalism on the high intensity of exploitation and conflict in struggling for urban space.Â Modernization of the city is not merely efforts to create a city comfortable and hygienic, but the strategy of commerce urban space. Modernization of the colonial city has covered the suffering of most people that have their own way of living.Â Abstrak: Kolonialisme, kapitalisme dan kota adalah tiga unsur yang selalu berkorelasi. Pada awal abad ke-20 pertumbuhan kota tidak terlepas dari ekspansi ekonomi kapitalisme Belanda yang diwakili oleh industri perkebunan, perkantoran perdagangan, perkantoran asuransi dan kawasan perbelanjaan elit. Proses ini diikuti dengan eksploitasi ruang kota. Ketika rezim berganti pada awal 1942, pertumbuhan simbol kapitalisme di kota itu dihentikan oleh Pemerintah Militer Jepang. Artikel ini mencoba menjelaskan hubungan antara perkembangan kapitalisme, modernisasi kota dan pengaruhnya terhadap masyarakat. Untuk menjelaskan hubungan tersebut, penulis menggunakan metode sejarah dengan menggunakan laporan pemerintah kota. Berdasarkan analisis laporan pajak kota dan respon masyarakat adat yang tinggal bersama di kota dapat disimpulkan bahwa terdapat pengaruh kapitalisme terhadap tingginya intensitas eksploitasi dan konflik dalam memperebutkan ruang kota. Modernisasi kota bukan semata-mata upaya menciptakan kota yang nyaman dan bersih, tetapi strategi perdagangan ruang kota. Modernisasi kota kolonial telah menutupi penderitaan sebagian besar masyarakat yang memiliki cara hidup sendiri-sendiri.Â Â
The Dutch Position in World War II in Sedjarah Umum Textbook by Anwar Sanusi
Authors: Rusmiati Desi
Published: September 2022

Abstract: This article discusses Sedjarah Umum written by Anwar Sanusi, namely the historiography of history textbooks in transitional historical records. At the beginning of Indonesia's independence, textbooks for history subjects was faced a non-centric and Indonesian-centric examination style. Neerlando-centric is a style that studies old historiography that is used mostly by colonial education. Choosing Indonesia-centric was a new style of writing after independence which had the purpose of writing a history that made the Indonesian nation the main actor. Still, it did not solve the history of Europeans in the Indies. The method used in this study is discourse analysis. The results of the study in this paper are (1) The writing of the Sedjarah Umum textbook written by Anwar Sanusi can be published using Neerlando centric and Indonesian centric; (2) The Dutch in World War II were shown as mediators and victims; (3) Indonesia-centric is indicated by mentioning Indonesia as a unified country. This study also compares textbooks published by the Sedjarah Umum of Anwar Sanusi's works based on the analysis: there are Neerlando centric and Indonesia-centric approaches.Â Abstrak: Artikel ini membahas tentang historiografi Sedjarah Umum karangan Anwar Sanusi yaitu historiografi buku ajar sejarah dalam masa transisi. Pada awal kemerdekaan Indonesia, buku teks pelajaran sejarah dihadapkan pada gaya ujian non sentris dan Indonesia sentris. Neerlando-sentris adalah gaya yang mempelajari historiografi lama yang sebagian besar digunakan oleh pendidikan kolonial. Memilih Indonesia-sentris adalah gaya penulisan baru setelah kemerdekaan yang bertujuan untuk menulis sejarah yang menjadikan bangsa Indonesia sebagai pemeran utamanya, tetapi tidak menyelesaikan sejarah bangsa Eropa di Hindia Belanda. Metode yang digunakan dalam penelitian ini adalah analisis wacana. Hasil penelitian dalam makalah ini adalah (1) Penulisan buku teks Sedjarah Umum karangan Anwar Sanusi diterbitkan dengan menggunakan Nerlando centric dan Indonesian centric; (2) Belanda dalam Perang Dunia II ditampilkan sebagai mediator dan korban; (3) Indonesia-sentris ditunjukkan dengan menyebut Indonesia sebagai negara kesatuan. Studi ini juga membandingkan buku teks Sedjarah Umum Anwar Sanusi berdasarkan pendekatan Neerlando centric dan Indonesia-centric.Â Â