bluuebunny/crossref_metadata_2025 huggingface dataset:
The psychosocial needs of adolescent and young adult kidney transplant recipients, and associated interventions: a scoping review
Authors: Wurm Fina , McKeaveney Clare , Corr Michael , Wilson Anna , Noble Helen
Published: July 2022

Background

Renal transplantation is considered the gold standard treatment for end-stage kidney disease. Adolescent and young adult kidney transplant recipients have the highest rate of graft loss amongst transplanted patients. It is largely accepted this is due to psychosocial and behavioural difficulties, which impact adherence to prescribed therapies. This phenomenon is not isolated to a particular healthcare system having been observed in multiple countries across different continents. It is a global issue of concern. We sought to review the psychosocial needs of these patients, and the interventions designed to meet these needs.

Methods

A scoping review was conducted based on Arksey and O’Malley’s six-stage framework. Eligibility criteria included primary studies of any type that investigated the psychosocial needs of adolescent and/or young adult renal transplant recipients or studies which examined interventions designed to address these needs. Search strategies were developed and conducted on PsycINFO, PubMed, Embase, and CINAHL. Articles meeting the inclusion criteria were critically reviewed using a descriptive-analytical narrative method.

Results

Thirty-nine studies met our inclusion criteria, 30 of which related to psychosocial needs, and the remainder examined psychosocial interventions. Four main themes were derived from our analysis of psychosocial needs literature, as follows: the need for (1) emotional support, (2) acceptance, (3) direction, (4) equality in healthcare. 2 main themes emerged from analysis of psychosocial intervention literature, namely: psychosocial (1) capability, (2) assessment. Despite the evidence that graft health is strongly associated with psychosocial wellbeing, findings revealed a significant lack of literature investigating how best to meet psychosocial needs. Trends were observed amongst intervention studies, namely interventions of novel and non-evidenced based design, with the aim of improving medication adherence through organisational strategies and education. However, literature regarding psychosocial needs showed non-adherence to therapies was not simply a result of disorganisation or lack of understanding, but rather, was founded on a recipient’s idiosyncratic relationship with their prescribed therapies e.g., psychological, social or financial reasons for non-adherence.

Conclusions

Future research should be directed at investigating the efficacy of evidence-based interventions that empower the individual patient to overcome their specific barrier to an optimal relationship with their therapies.
Pharmacological evaluation of newly synthesized organotin IV complex for antiulcer potential
Authors: Azmatullah Syed , Khan Arif-ullah , Qazi Neelam Gul , Nadeem Humaira , Irshad Nadeem
Published: July 2022

The present study aims to investigate the newly synthesized organotin (IV) complex (2E, 2′E) dibutylstannanediyl bis (4-(4-nitrophenyl) amino)-4-oxobut-2-enoate (DTN) for its anti-ulcer potential. Characterization performed by carbon nuclear magnetic resonance spectroscopy proved that all values are in the expected ranges of the new compound. Gastroprotective activity of DTN was evaluated throughin-silico,anti-H. pylori,in-vitro,in-vivo, and ex-vivo proteomic analysis.In-silicoanalysis shows that DTN possess stable binding with protein targets involved in gastric ulcer pathophysiology. DTN exhibited an inhibitory effect against 2,2-diphenyl-1-picrylhydrazyl,H. pyloriand hydrogen potassium ATPase (H+/K+-ATPase). The antiulcer activity was performed using an ethanol-induced gastric ulcer model in rats. Anti-oxidant profile of DTN showed a significant increase in glutathione-S-transferase, glutathione and catalase levels whereas lipid peroxidation levels were reduced. Histopathological findings confirmed that DTN protected the gastric mucosa of rats. Inflammatory markers tumor necrosis factor-alpha, nuclear factor kappa B, cyclooxygenase-2, interleukin 6 and interleukin-1β were reduced and prostaglandin-E2restored expression of these cytokines in DTN pretreated animals when analyzed by using immunohistochemistry, enzyme-linked immunosorbent assay and western blot techniques. In real-time polymerase chain reaction technique, the expression of H+/K+-ATPase was downregulated in DTN pretreated group. DTN did not cause any mortality up to 400 mg/Kg. This study indicates that the newly synthesized compound DTN, possess stable binding against selected targets. DTN exhibits a gastro-protective effect, mediated via anti-H. pylori,H+/K+-ATPase inhibition, anti-oxidant and anti-inflammatory pathways, exploring its therapeutic potential in gastric ulcer management.
The need for a functional pharmaceutical industry in Sierra Leone: lessons from the COVID-19 pandemic
Authors: Conteh Eugene , Okereke Melody , Turay Foday Umaro , Bah Alhaji Sununu , Muhsinah Abdulwasiu
Published: July 2022

With an estimated population of 8.3 million, Sierra Leone has no existing pharmaceutical manufacturing company at present. The recent COVID-19 pandemic brought to the limelight the fragility and weakness of the Sierra Leonean pharmaceutical industry as it resulted in severe drug shortages and medicine insecurity in the country due to the restrictions imposed on importations, which validates the uncertainties if the country can sufficiently meet its local pharmaceutical needs and health demands. In this paper, we highlight the current situation of the Sierra Leonean pharmaceutical sector and provide recommendations for the country towards building a functional pharmaceutical industry based on lessons learnt from the COVID-19 pandemic.
Combined cardiac surgery in a Marfan syndrome patient with severe scoliosis via lower hemisternotomy: a case report
Authors: Sakamoto Shun-Ichiro , Amitani Ryosuke , Motoji Yusuke , Yamaguchi Takako , Hiromoto Atsushi , Suzuki Kenji , Ishii Yosuke
Published: July 2022

Background

Scoliosis is one of the symptoms manifested by patients with Marfan syndrome (MFS). Deformity of the thoracic cavity due to severe scoliosis may cause difficulty during cardiac surgery in terms of the surgical approach and instrument manipulation; however, only a few reports have been available regarding the surgical case of MFS with severe scoliosis. Here, we report a case of combined aortic valve replacement and left atrial appendage closure in a patient with MFS who had severe scoliosis using lower hemisternotomy.

Case presentation

A 62-year-old female with MFS was referred to our hospital after being diagnosed with severe aortic regurgitation and paroxysmal atrial fibrillation with a history of cerebral thromboembolism. The aortic valve showed severe insufficiency due to cusp prolapse, whereas the aortic root was moderately dilated (42 mm). Echocardiography revealed severe regurgitation with reduced left ventricular ejection function (32%) and massive left ventricular diastolic dimension (88 mm). Moreover, combined aortic valve replacement and left atrial appendage closure was indicated. However, the patient had chest deformity due to severe scoliosis. Thus, conventional full sternotomy or thoracotomy was considered an inappropriate surgical approach. Lower hemisternotomy was selected on the basis of three-dimensional reconstruction imaging of the aorta, left atrial appendage, sternum, and rib. Sternal elevation and rib retraction with the costal arch folded back provided enough surgical field for the combined procedures to be safely conducted. The postoperative course was uneventful, except for predicted prolonged mechanical ventilation with the assistance of intraaortic balloon pumping. Thereafter, the patient has been free from any cardiac and cerebrovascular event.

Conclusions

Lower hemisternotomy can be useful for combined cardiac surgery in MFS with severe scoliosis.
Enhancing the health of NHS staff: eTHOS — protocol for a randomised controlled pilot trial of an employee health screening clinic for NHS staff to reduce absenteeism and presenteeism, compared with usual care
Authors: Adams Rachel , Jordan Rachel , Adab Peymané , Barrett Tim , Bevan Sheriden , Cooper Lucy , DuRand Ingrid , Hardy Pollyanna , Heneghan Nicola , Jolly Kate , Jowett Sue , Marshall Tom , O’Hara Margaret , Rai Kiran , Rickards Hugh , Riley Ruth , Sadhra Steven , Tearne Sarah , Walters Gareth , Sapey Elizabeth
Published: July 2022

Background

Staff absenteeism and presenteeism incur high costs to the NHS and are associated with adverse health outcomes. The main causes are musculoskeletal complaints and mental ill-health, which are potentially modifiable, and cardiovascular risk factors are also common. We will test the feasibility of an RCT to evaluate the clinical and cost-effectiveness of an employee health screening clinic on reducing sickness absenteeism and presenteeism.

Methods

This is an individually randomised controlled pilot trial aiming to recruit 480 participants. All previously unscreened employees from four hospitals within three UK NHS hospital Trusts will be eligible. Those randomised to the intervention arm will be invited to attend an employee health screening clinic consisting of a screening assessment for musculoskeletal (STarT MSK and STarT Back), mental (PHQ-9 and GAD-7) and cardiovascular (NHS Health Check if aged ≥ 40, lifestyle check if < 40 years) health. Screen positives will be given advice and/or referral to recommended services. Those randomised to the control arm will receive usual care. Participants will complete a questionnaire at baseline and 26 weeks; anonymised absenteeism and staff demographics will also be collected from personnel records. The co-primary outcomes are as follows: recruitment, referrals and uptake of recommended services in the intervention arm. Secondary outcomes include the following: results of screening assessments, uptake of individual referrals, reported changes in health behaviours, acceptability and feasibility of intervention, indication of contamination and costs. Outcomes related to the definitive trial include self-reported and employee records of absenteeism with reasons. Process evaluation to inform a future trial includes interviews with participants, intervention delivery staff and service providers receiving referrals. Analyses will include presentation of descriptive statistics, framework analysis for qualitative data and costs and consequences presented for health economics.

Discussion

The study will provide data to inform the design of a definitive RCT which aims to find an effective and cost-effective method of reducing absenteeism and presenteeism amongst NHS staff. The feasibility study will test trial procedures, and process outcomes, including the success of strategies for including underserved groups, and provide information and data to help inform the design and sample size for a definitive trial.

Trial registration

ISRCTN reference number 10237475.
Developing a method to assess fidelity to a complex vocational rehabilitation intervention in the FRESH trial: a feasibility study
Authors: Holmes Jain Anne , Fletcher-Smith Joanna Clare , Merchán-Baeza Jose Antonio , Phillips Julie , Radford Kathryn
Published: July 2022

Background

Determining whether complex rehabilitation interventions are delivered with fidelity is important. Implementation fidelity can differ between sites, therapists delivering interventions and, over time, threatening trial outcomes and increasing the risk of type II and III errors. This study aimed to develop a method of assessing occupational therapists’ fidelity to deliver a complex, individually tailored vocational rehabilitation (VR) intervention to people with traumatic brain injury (TBI) and assess the feasibility of its use in a randomised controlled trial.

Methods

Using mixed methods and drawing on the intervention logic model, we developed data collection tools to measure fidelity to early specialist TBI VR (ESTVR). Fidelity was measured quantitatively using intervention case report forms (CRF), fidelity checklists and clinical records. Qualitative data from mentoring records, interviews with intervention therapists, participants with TBI, employers and NHS staff at trial sites explored moderators of implementation fidelity. The conceptual framework of implementation fidelity (CFIF) guided measurement and analysis of and factors affecting fidelity. Data were triangulated and benchmarked against an earlier cohort study.

Results

Fidelity to a complex individually tailored VR intervention could be measured. Overall, OTs delivered ESTVR with fidelity. Different fidelity measures answered different questions, offering unique insights into fidelity. Fidelity was best assessed using a fidelity checklist, intervention CRFs and clinical notes. The OT clinical notes and mentoring records were best at identifying fidelity moderating factors. Interviews added little insight into fidelity moderating factors over and above mentoring or clinical records. Data triangulation offered a comprehensive assessment of fidelity, highlighting limitations of measurement methods and learning for future trials but was resource intensive. Interviews, fidelity visits and analysing clinical notes were also resource intense. Comparing fidelity data to a benchmark and using CFIF as a framework for organising the fidelity assessment helped.

Conclusions

OTs delivered the VR intervention with fidelity. A fidelity checklist and benchmark plus mentoring may offer a practical and effective way of measuring fidelity and identifying fidelity moderating factors in trials of complex individually-tailored rehabilitation interventions. Mentoring provided real-time indicators of and reasons for fidelity deviations. These methods require further evaluation.

Trial registration

ISRCTN Registry, ISRCTN38581822 (Registered: 02/01/2014).
Supporting successful recruitment in a randomized control trial comparing clinic and home-based exercise among adults with multiple sclerosis
Authors: Tracy Tracy Flemming , Young Hui-Ju , Lai Byron , Layton Beverly , Stokes Dolly , Fry Mark , Mehta Tapan , Riser Emily S. , Rimmer James
Published: July 2022

Background

The Tele- Exercise and Multiple Sclerosis (TEAMS) study, funded by the Patient Centered Outcome Research Institute (PCORI), is a pragmatic, cluster randomized controlled trial aimed at comparing the effectiveness of a 12-week complementary and alternative medicine (CAM) program for people with multiple sclerosis (MS) delivered by a therapist at a clinic and the same program initiated by the participant at home using a tablet and pre-recorded videos. The 20-session CAM program consists of yoga, Pilates and dual tasking exercises. The study aimed to enroll 820 participants with MS living in Alabama, Mississippi and Tennessee.

Main Body

The information provided in this paper describes the strategies that led to the largest randomized controlled exercise trial ever conducted for people with multiple sclerosis. Specifically, the paper presents the result of incorporating stakeholder engagement, a novel participant recruitment method, to produce a successful recruitment outcome for a comparative effectiveness randomized controlled trial. This study used three tiers of engagement: panel members (9 members), clinical partners (88 occupational and physical therapists), and community organizations (6 non-profits).

Conclusion

Engagement of the stakeholder panel, clinical partners and community organizations led to interest of over 1700 people with MS across three states in the Deep South (final enrollment was n = 837). The diversity of our stakeholder groups and their extensive reach into various communities were a critical aspect for achieving our target sample size. The recruitment numbers reflect the importance of involving multiple stakeholder groups at project inception, developing relationships over time, utilizing member strengths, and monitoring their engagement on a regular basis to ensure a meaningful experience for all involved.

Trial registration: NCT03117881. Registered 18 April 2017, https://clinicaltrials.gov/ct2/show/NCT03117881?term=tele+rehabilitation&cond=Multiple+Sclerosis&cntry=US&state=US%3AAL&draw=2&rank=1.
Forecasting worldwide empty container availability with machine learning techniques
Authors: Martius Christoph , Kretschmann Lutz , Zacharias Miriam , Jahn Carlos , John Ole
Published: July 2022

Due to imbalances in the global transport of containerised goods, liner shipping companies go to great lengths to match the regional supply and demand for empty containers by transporting equipment from surplus to deficit regions. Making accurate forecasts of regional empty container availability could support liner companies and other involved actors by making better relocation decisions, thus avoiding unnecessary transport costs of empty equipment. Previously proposed container availability prediction models are limited to the application in individual regions and typically characterized by a high degree of temporal aggregation. Against this background, this paper introduces two novel approaches based on machine learning and probabilistic techniques to predict the future weekly availability of empty containers for more than 280 locations worldwide. The machine learning and probabilistic prediction models are built by analysing a unique data set of more than 100 million events from past container journeys. These events represent different stages during the transport process of a container. Both models use a two-step forecast logic. First, the expected future location of a container is predicted. Second, the expected timestamp for arriving at that location is estimated. The machine learning model uses artificial neural networks and mixture density networks to forecast the movements of containers. The models are quantitatively assessed and compared to the actual availability of containers and two more conventional forecasting approaches. The results indicate that the probabilistic prediction approach can keep up with conventional approaches while the neural network approach significantly outperforms the other approaches concerning every evaluation metric.
Hunters and fowlers in the Tungabhadra Plains of Andhra Pradesh, South India: an ethnographical study of Nir Sikaris
Authors: Raghu Yadava
Published: July 2022

Hunting and gathering, which date back to the Middle Pleistocene, are the oldest sources of sustenance. Practically, these hunting and gathering societies have gradually expanded their settlements and culture across the country. The present paper attempts a qualitative ethnographical study on the ongoing life of the Nir Sikaris which is one of the hunting and fowling tribes in the Tungabhadra Plains of Andhra Pradesh. Primarily it focuses on their settlement patterns, subsistence strategies, and living traditions. S(h)ikar means hunting; Sikari means hunter. They populate Kurnool, Anantapur (Andhra Pradesh), Bellary (Karnataka) Districts and Maharashtra. They were labelled with a social stigma of a criminal tribe under the British Raj and were also considered ex-criminal tribe and de-notified tribe in post-independence India. They are currently classified as one of the backward classes (B.C.-A) by the State Government of Andhra Pradesh. It becomes vital to shedding light on documentation of Nir Sikaris’ evolving cultural life for posterity, as they are culturally transforming due to modernization in the current globalised society.
Development of a novel patient-reported outcome measure to assess signs and symptoms of COVID-19
Authors: Romano Carla , Fehnel Sheri , Stoddard Jeffrey , Sadoff Jerald , Lewis Sandy , McNulty Pauline , Chan Eric K. H. , Evans Emily , Jamieson Carol , Slagle Ashley F. , Mangel Allen , McQuarrie Kelly
Published: July 2022

Background

Given the urgent need for vaccines and treatments for coronavirus disease 2019 (COVID-19), the Symptoms of Infection with Coronavirus-19 (SIC), a comprehensive, patient-reported outcome (PRO) measure of signs and symptoms associated with COVID-19, was developed in full alignment with current US regulatory guidance to support evaluations of vaccines and treatments in development.

Methods

An initial version of the SIC was developed to address concepts identified through a targeted literature review and consultation with experts in infectious diseases and clinicians routinely managing COVID-19 in a hospital setting. A qualitative study was conducted in sites in the United States among 31 participants aged ≥ 18 years who were English-speaking and willing and able to provide informed consent and a self-reported history by telephone or online method. The measure was refined based on additional feedback from the clinicians and three iterative rounds of combined concept elicitation and cognitive debriefing interviews conducted with patients, caregivers, and healthy volunteers.

Results

Among 39 scientific articles identified in the literature review, 35 COVID-19 signs and symptoms were reported and confirmed during interviews with clinicians, patients, and caregivers. Patients and healthy participants suggested changes for refining the draft SIC to ensure consistent interpretation and endorsed both the 24-h recall period and use of an 11-point numeric rating scale (NRS) for capturing change in symptom severity. The final version of the SIC captures the daily presence or absence of 30 symptoms and a rating of severity for 25 of the 30 symptoms using an NRS for those symptoms reported as present.

Conclusions

The SIC comprehensively addresses observations described in the literature, by clinicians, and by patients, and captures patients’ experiences with COVID-19 in a manner that minimizes complexity and facilitates completion for both patients and healthy volunteers. This measure is thus appropriate for use in clinical trials of both therapeutics and vaccines for COVID-19.
Conceptualisation of a measurement framework for Needs-based Quality of Life among patients with multimorbidity
Authors: Bissenbakker Kristine , Møller Anne , Brodersen John Brandt , Jønsson Alexandra Brandt Ryborg
Published: July 2022

Background

Multimorbidity is both an individual and societal problem. For society, patients with multimorbidity increase healthcare costs. For the individual, living with multimorbidity is complex, and there is an inverse relationship between a patient's Quality of Life (QoL) and their number of chronic conditions. Numerous intervention studies target these problems, yet there is no multimorbidity-specific patient-reported outcome measure (PROM) developed specifically for this group with adequate measurement properties to assess QoL. This study explores what overall needs regarding QoL are affected by living with multimorbidity through qualitative interviews. With this, we conceptualise Needs-based QoL specifically for this group, ensuring high content validity (regarding relevance and comprehensiveness) of using the Needs-based approach to measure their QoL. This is essential as this preliminary study leads to the development of the MultiMorbidity Questionnaire (MMQ), a PROM measuring QoL among patients with multimorbidity.

Methods

This study draws upon qualitative interviews with fifteen patients with multimorbidity based on a semi-structured interview guide following the Needs-based approach. This approach allowed the patients to cover needs relevant for their QoL in relation to the complexities of living with multimorbidity. The transcribed interviews were thematically analysed, inspired by Braun and Clarke’s reflexive approach.

Results

Analysis of the interviews resulted in the construction of six intertwined domains relevant to patients with multimorbidity, covering their Needs-based QoL; “Physical ability”, “Self-determination”, “Security”, “Partner and social life”, “Self-image”, and “Personal finances”. “Physical limitations” and “Personal finances” were stated as core needs implicating the other domains.

Conclusion

This study shows six intertwined overall domains relevant for patients with multimorbidity regarding their Needs-based QoL; “Physical ability”, “Self-determination”, “Security”, “Partner and social life”, “Self-image”, and “Personal finances”. These needs are relevant in a Danish context, with a generally high standard of living. Based on this conceptual framework of Need-based QoL for patients with multimorbidity, we will develop items for a new patient-reported outcome measure called the MMQ.
Photon-counting detector CT and energy-integrating detector CT for trabecular bone microstructure analysis of cubic specimens from human radius
Authors: Klintström Benjamin , Henriksson Lilian , Moreno Rodrigo , Malusek Alexandr , Smedby Örjan , Woisetschläger Mischa , Klintström Eva
Published: July 2022

Background

As bone microstructure is known to impact bone strength, the aim of this in vitro study was to evaluate if the emerging photon-counting detector computed tomography (PCD-CT) technique may be used for measurements of trabecular bone structures like thickness, separation, nodes, spacing and bone volume fraction.

Methods

Fourteen cubic sections of human radius were scanned with two multislice CT devices, one PCD-CT and one energy-integrating detector CT (EID-CT), using micro-CT as a reference standard. The protocols for PCD-CT and EID-CT were those recommended for inner- and middle-ear structures, although at higher mAs values: PCD-CT at 450 mAs and EID-CT at 600 (dose equivalent to PCD-CT) and 1000 mAs. Average measurements of the five bone parameters as well as dispersion measurements of thickness, separation and spacing were calculated using a three-dimensional automated region growing (ARG) algorithm. Spearman correlations with micro-CT were computed.

Results

Correlations with micro-CT, for PCD-CT and EID-CT, ranged from 0.64 to 0.98 for all parameters except for dispersion of thickness, which did not show a significant correlation (p = 0.078 to 0.892). PCD-CT had seven of the eight parameters with correlations ρ > 0.7 and three ρ > 0.9. The dose-equivalent EID-CT instead had four parameters with correlations ρ > 0.7 and only one ρ > 0.9.

Conclusions

In this in vitro study of radius specimens, strong correlations were found between trabecular bone structure parameters computed from PCD-CT data when compared to micro-CT. This suggests that PCD-CT might be useful for analysing bone microstructure in the peripheral human skeleton.
Reactive glia-to-GABAergic neuron reprogramming: a “golden touch” strategy to alleviate intractable seizures
Authors: Chen Junzi , Li Zhongxia , Chen Liying
Published: July 2022

This commentary highlights a research article published recently in Cell Stem Cell “Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy”. Generally, Lentini et al. reveal a strategy to fulfill in vivo glia-to-neuron reprogramming, which is a potential disease-modifying strategy for treatment of intractable seizures. Here, we describe exciting research advances in the treatment of intractable seizures based on this research article, summarizing its key findings, emphasizing its importance and providing further discussions. Further, issues worthy of further investigations are also postulated so that clinic translation can be better achieved.
The association of iron deficiency anemia and perioperative complications following revision total knee arthroplasty
Authors: Hamaway Stefan , Hadid Bana , Vakharia Rushabh M. , Ng Mitchell K. , Gordon Adam M. , Roche Martin W. , Razi Afshin E.
Published: July 2022

Background

Recent studies show an increase in the prevalence of iron deficiency anemia (IDA) worldwide and a concomitant rise in the number of revision total knee arthroplasty (RTKA). The literature evaluating the association between IDA and perioperative outcomes following RTKA are limited. Therefore, the purpose of this study was to determine whether IDA patients undergoing RTKA have higher rates of (1) in-hospital lengths of stay (LOS), (2) complications; and (3) costs.

Methods

Using International Classification of Disease, Ninth Revision (ICD-9) and Current Procedural Terminology (CPT), a retrospective query was performed from January 1st, 2005 to March 31st, 2014. The inclusion criteria consisted of those patients who have IDA undergoing RTKA. Study group patients were 1:5 ratio matched to a comparison cohort by age, sex, and various comorbidities: coronary artery disease, chronic obstructive pulmonary disease, diabetes mellitus, hyperlipidemia, hypertension, obesity, and tobacco use, yielding a total of 106,534 patients within the study (n = 17,784) and control (n = 88,750) cohorts. Outcomes assessed included: in-hospital LOS, costs of care, and medical complications. Multivariate Logistic regression analyses were used to calculate the odds-ratios (OR) and respective 95% confidence intervals (95%CI). Welch’s t-tests were used to compare in-hospital LOS and costs of care. Following Bonferroni-correction, a P-value less than 0.001 was considered statistically significant.

Results

IDA patients undergoing RTKA were found to have significantly higher in-hospital LOS (4-days vs. 3-days, P < 0.0001). Additionally, IDA patients were found to have significantly higher odds (OR) of medical complications (OR: 5.29, P < 0.0001) such as: pneumonia (OR: 6.86, P < 0.0001), respiratory failures (OR: 5.95, P < 0.0001), myocardial infarctions (OR: 4.31, P < 0.0001) and other complications. Furthermore, IDA patients incurred significantly higher day of surgery ($16,976.01 vs. $14,515.81, P < 0.0001) and 90-day costs ($22,548.71 vs. $16,819.15, P < 0.0001).

Conclusion

The study demonstrated IDA patients undergoing RTKA have higher rates of in-hospital LOS, costs of care, and medical complications. Orthopedic surgeons and other healthcare professionals can use this information to adequately educate these patients of the potential complications following their procedure.
Antihyperglycemic activity of verbenone and L-arginine in nicotinamide-streptozotocin-induced diabetic mice: in vitro and in vivo studies
Authors: Tijjani Habibu , Danyaro Abdulkadir Mohammed , Olatunde Ahmed , Kura Aminu Umar
Published: July 2022

Background

Natural products are utilized globally for the management of diseases such as diabetes mellitus. Carrot seeds are ethnobotanically used in the management of diabetes mellitus. This study investigated the in vitro and in vivo antihyperglycemic activities of verbenone and L-arginine, which are compounds found in carrot seed.

Results

Verbenone, L-arginine, and their ratios combination expressed significantly in vitro α-amylase inhibitory activity with IC50 of 13.00, 12.69, and 13.30 µg/mL respectively compared with acarbose (IC50 = 12.64 µg/mL) and significant in vitro α-glucosidases inhibitory activity with IC50 of 29.01, 23.76 and 30.11 µg/mL respectively compared with acarbose (IC50 = 16.80 µg/mL). Furthermore, the compounds improved glucose uptake in yeast cells and inhibited haemoglobin glycation in vitro. In the in vivo study, the compounds significantly reduced the levels of blood glucose, the levels of liver total cholesterol, and liver triacylglycerol, the calculated cardiovascular indices, whereas the level of plasma high density lipoprotein (HDL) cholesterol was significantly elevated in all diabetic treated mice.

Conclusion

The data revealed the in vitro antidiabetic activity of verbenone and L-arginine. Also, the compounds ameliorated hyperglycemia, hyperlipidemia and other diabetic-induced biochemical alterations in NAD-STZ-induced diabetic mice model.
Does grip strength of the less-affected side of ischemic stroke survivors influences performance of self-care activities?
Authors: Ademoyegun Adekola Babatunde , Mbada Chidozie Emmanuel , Sonuga Oluwatobi Ademola , Malomo Oluwatobi Elijah , Fatai Wasiu Abiodun , Aghedo Ishanosen Abidemi
Published: July 2022

Background and aim

Adequate grip strength is needed to execute various self-care activities. This study was aimed to assess the influence of grip strength of the less-affected side of ischemic stroke survivors on performance of self-care activities, and also to determine the reference values of less-affected grip strength needed for independent performance of each of the self-care activities.

Methods

Seventy-three consenting patients with ischemic stroke participated in this cross-sectional study. Handheld dynamometer was used to measure grip strength of the less-affected hand, while functional independence measure was used to evaluate self-care activities (eating, grooming, bathing, dressing of upper body, dressing of lower body and toileting) as independent and dependent. Data was analyzed using inferential statistics of Pearson’s correlation, binomial logistic regression, and receiver operating characteristics. Alpha level was set at p < 0.05.

Results

The mean hand grip strength, functional independence measure and trunk control test scores were 23.8 kg, 29.9 kg, and 68.2 kg respectively. Grip strength was significantly associated with independence in all of the self-care activities (p < 0.05). Less-affected grip strength of 19.5 kg (sensitivity, 80.4%; specificity, 80.1%; area under curve, 0.85), 23.7 kg (sensitivity, 79%; specificity, 72.2%; area under curve, 0.79), 24.8 kg (sensitivity, 70.2%; specificity, 65.2%; area under curve, 0.75), 24.7 kg (sensitivity, 82.1%; specificity, 80.1%; area under curve, 0.84), 23.7 kg (sensitivity, 80.1%; specificity, 76.1%; area under curve, 0.84), and 19.9 kg (sensitivity, 76.9%; specificity, 76.2%; area under curve, 0.79) was needed for independent performance in eating, grooming, bathing, dressing of upper body, dressing of lower body, and toileting respectively.

Conclusion

The less-affected grip strength of patients with ischemic stroke influences their ability to independently perform self-care activities. The reference values of less-affected grip strength in association with other stroke-related characteristics may help clinicians to estimate independence in eating, grooming, bathing, dressing of upper body, dressing of lower body, and toileting among patients with ischemic stroke.
Postauricular dermoid cyst: a rare lesion in an extremely rare location
Authors: Aljeaid Dhaifallah , Alharthi Ahmad , Alotaibi Ohoud , Altalhi Wahaj
Published: July 2022

Background

Dermoid cysts are benign lesions commonly seen in the body’s midline, such as the orbit, oral cavity, and nose. They are rare in the head and neck and exceptionally rare in and around the auricle.

Case presentation

A case of postauricular dermoid cyst in a 28-year-old female patient is reported. The clinical features, diagnosis, and management of this rare clinical condition are reviewed.

Conclusion

A postauricular dermoid cyst is an extremely rare clinical condition; however, it should be considered in the differential diagnosis of any cystic lesion around the auricle.
Early Detection of Relapse by ctDNA Sequencing in a Patient with Metastatic Thymic Tumor and MEN1 Mosaicism
Authors: Lagarde Arnaud , Le Collen Lauriane , Boulagnon Camille , Brixi Hedia , Durlach Anne , Mougel Grégory , Cuny Thomas , Delemer Brigitte , Barlier Anne , Romanet Pauline
Published: July 2022

Context

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disease caused by inactivating mutations in the MEN1 gene. In the literature, few cases of MEN1 have been reported because of mosaic MEN1 mutations.

Objective

We performed an extensive molecular characterization in several lesions and blood samples, including plasmatic circulating cell-free DNA (ccfDNA) in an exceptional case of a patient with MEN1 mosaicism causing primary hyperparathyroidism, multiple pancreatic neuroendocrine tumors (NETs), and a metastatic thymic NET.

Methods

Blood, ccfDNA and multiple tissue analysis were performed by next-generation sequencing.

Results

MEN1 mosaicism was confirmed by multiple tissue analysis. Somatic analysis of the largest pancreatic NET revealed the same MEN1 second-hit mutation as found in the thymic lesion, demonstrating its metastatic origin from the thymic lesion. Moreover, in ccfDNA we found the mosaic MEN1 mutation but also the somatic second-hit mutation found in the thymic primary tumor, revealing the presence of circulating tumor DNA (ctDNA). After surgical removal of the pancreatic metastasis, the mutated fraction of both mutations decreased, before increasing again several weeks before a new clinical relapse, suggesting that thymic ctDNA may be used as an early tumor biomarker.

Conclusion

This exceptional MEN1 case highlighted (1) the importance of looking for MEN1 mosaicism, (2) that MEN1 mosaicism can cause very aggressive disease, and (3) the interest in analyzing ccfDNA for confirming MEN1 mosaicism but also as a potential tumor biomarker for NET.
Linking neural crest development to neuroblastoma pathology
Authors: Gonzalez Malagon Sandra Guadalupe , Liu Karen J.
Published: July 2022

Although rare, childhood (paediatric) cancers are a major cause of death in young children. Unlike many adult cancers, paediatric cancers, such as neuroblastoma (NB), are developmental diseases that rarely show genetic predispositions. NB is the most common extracranial solid tumour in children, accounting for ∼15% of paediatric cancer deaths. This heterogeneous cancer arises from undifferentiated neural crest-derived progenitor cells. As neural crest cells are multipotent and migratory, they are often considered the embryonic paradigm of cancer stem cells. However, very little is known about the events that trigger tumour initiation and progression. Here, we discuss recent insights into sympathoadrenal lineage specification, as well as genetic factors associated with NB. With this in mind, we consider the molecular underpinnings of NB in the context of developmental trajectories of the neural crest lineage. This allows us to compare distinct subtypes of the disease and gene-function interactions during sensitive phases of neural crest development.
Housing Lock: Dutch Evidence on the Impact of Negative Home Equity on Household Mobility
Authors: Bernstein Asaf , Struyven Daan
Published: July 2022

This paper employs Dutch administrative population data to test the “housing lock hypothesis”: the conjecture that homeowners with negative home equity, low levels of financial assets, and restricted opportunities to borrow reduce their mobility. Variation in home equity driven by the timing of home purchase within a municipality and the harshness of Dutch recourse laws facilitates identification of housing lock effects. The 2SLS estimate for the effect of negative home equity is a 74–79 percent decline in mobility, where effects are substantially larger for households with low financial asset holdings or moves over longer distances. (JEL G51, R21, R23, R31)
Does Virtual Advising Increase College Enrollment? Evidence from a Random-Assignment College Access Field Experiment
Authors: Phillips Meredith , Reber Sarah
Published: July 2022

Although in-person college access programs can be effective, less is known about whether low-cost and scalable virtual interventions can achieve the same benefits. We evaluate two variants of a virtual college counseling program. Students randomly assigned to the program felt more supported applying to college and applied more broadly to four-year colleges, but were not more likely to be accepted or enroll. We analyze rich and extensive survey data to explore mechanisms and why the program did not improve college enrollment. We conclude that low-intensity programs may work for some students, but many probably need in-person and intensive help. (JEL C93, I23, I24, I28, L31)
The global prevalence and association between the risk of myocarditis and mRNA-based COVID-19 vaccination: A network meta-analysis
Authors: Rohman Mohammad , Fajar Jonny Karunia , Soegiarto Gatot , Wulandari Laksmi , Anshory Muhammad , Ilmawan Muhammad , Marlysawati Dewi , Purnamasari Yeni , Kusuma Andy Pranata , Asmiragani Anisa , Adhiatma Dimas , Permana Andi , Pasaribu Erwin Alexander , Maliga Helnida Anggun , Pamungkas Yuri , Puteri Putu Wina Margarani , Sinaga Vebri Anita , Setiawan Dedy , Putri Effika Nurningtyas , Fattima Eliza Techa , Prawoto Olivia Listiowati , Safitri Rina , Yuliana Roma , Hikmah Kholisotul , Putri Yama Sirly , Nurzaidah Laili , Lianto Lianto , Cahya Meiliana Dwi , Ikhsan Muhammad , Ibrahim Ibrahim , Samudra Anggara Dwi , Tamara Fredo , Kartini Dessy Aprilia , Mahendra Aditya Indra , Dhama Kuldeep , Harapan Harapan
Published: July 2022

Background: Cases of myocarditis development have been reported after administration of messenger ribonucleic acid (mRNA)-based coronavirus disease (COVID-19) vaccines. However, the reports vary among the studies, and the types of mRNA vaccines with potential to cause myocarditis remain unidentified. The objective was to assess the cumulative prevalence of myocarditis and determine the association between myocarditis and mRNA-based COVID-19 vaccination.

Methods: We performed a network meta-analysis by searching articles in PubMed, Scopus, and Web of Science. Information on the prevalence of myocarditis after the mRNA-based COVID-19 vaccination was collected from each study. Analysis was performed by calculating the pooled prevalence rate, and the association was determined using the Z-test. Data networking was performed using the Bayesian method.

Results: A total of 18 papers was included in our analysis. We found that the cumulative prevalence of myocarditis was 1.7, 1.9, 1.2, and 1.1 per 100,000 population after vaccination with different types of mRNA-based COVID-19 vaccines, namely all mRNA COVID-19 vaccines, BNT162b1, mRNA-1273, and the combination of BNT162b1 and mRNA-1273, respectively. Moreover, the results revealed that BNT162b1 vaccination increased the risk of myocarditis by 1.64- and 1.71-folds compared to mRNA-1273 and the combination of BNT162b2 and mRNA-1273, respectively. Similar risks of developing myocarditis were observed after mRNA-1273 and the combination of BNT162b1 and mRNA-1273 vaccination.

Conclusions: Our findings suggest the cumulative prevalence of myocarditis after mRNA-based COVID-19 vaccination with maximum prevalence was observed after BNT162b2 administration. BNT162b2 was associated with a higher risk of developing myocarditis than the other mRNA-based COVID-19 vaccines.
Levels of cardiac troponin-T and LDL-C to HDL-C ratio of hospitalized COVID-19 patients: A case-control study
Authors: Sabah Khalid Shahad , Mohamed Ali Zahraa , Shareef Laith G.
Published: July 2022

Background: People with coronavirus disease 2019 (COVID-19) are frequently at higher risk of developing cardiovascular and metabolic disorders, which are strongly related to the development of long-term illness and higher mortality. These effects may be caused by several interrelated processes, including the IL-6 driven cytokine storm or uncontrolled angiotensin II stimulation. In addition, the direct viral infection of cardiac myocytes is thought to cause cardiac injury because it increases metabolic demand, activates the immune system, and causes vasculature disruption. The objective of this study was to determine whether there is a relationship between cardiac troponin-T (cTnT) and low-density lipoprotein cholesterol (LDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio values with COVID-19.

Methods: During the data collection stage, 90 participants were included, 45 healthy controls and 45 hospitalized patients diagnosed with COVID-19 using reverse transcription-quantitative PCR (RT-qPCR). Each participant provided 5 ml venous blood to begin analyzing cTnT and LDL-C:HDL-C ratio levels in their blood to see whether there is an association between the level of any of these markers and COVID-19 infection using SPSS version 23.

Results: This research reported a significant rise in the measured values of cTnT and LDL-C:HDL-C ratio in patients' blood compared to controls, with P-values of 0.025 and 0.000, respectively, in which alpha values < 0.05, These biomarkers hold the promise in predicting COVID-19 severity, and early treatment may help reduce complications.

Conclusions: Due to the fact that cTn is a diagnostic marker of disease activity and a strong independent predictor of negative events, its usage in emergency rooms may well be advantageous. If cTn is elevated, hospitalization may be indicated. A difference in the blood LDL-C:HDL-C ratio of COVID-19 patients demonstrated an association with the illness. Because lipid studies are inexpensive and reliable to do, they may aid clinicians in identifying the severity of COVID-19.
Uncertainties of particulate organic carbon concentrations in the mesopelagic zone of the Atlantic ocean
Authors: Strubinger Sandoval Paul , Dall'Olmo Giorgio , Haines Keith , Rasse Rafael , Ross Jelizaveta
Published: July 2022

Measurements of particulate organic carbon (POC) in the open ocean provide grounds for estimating oceanic carbon budgets and for modelling carbon cycling. The majority of the published POC measurements have been collected at the sea surface. Thus, POC stocks in the upper layer of the water column are relatively well constrained. However, our understanding of the POC distribution and its dynamics in deeper areas is still modest due to insufficient POC measurements. Moreover, the uncertainty of published POC estimates is not always quantified, and neither is it fully understood. In this study, we determined the POC concentrations of samples collected in the upper 500 m during an Atlantic Meridional Transect and described a method for quantifying its experimental uncertainties using duplicate measurements. The analysis revealed that the medians of the total experimental uncertainties associated with our POC concentrations in the productive and mesopelagic zones were 2(±2) mg/m3 and 3(±1) mg/m3, respectively. In relative terms, these uncertainties corresponded to ∼12% and ∼35% of POC concentrations, respectively. We modelled the POC uncertainty in order to identify its main causes. This model however could explain only ∼19% of the experimental POC uncertainty. Potential sources of the unexplained uncertainty are discussed.
Latin. LEGE ARTIS
Authors: Borisova E. O. , Driker M. B. , Morgunova O. V. , Olekhnovich O. G. , Tikhomirova A. V.
Published: July 2022

Учебное пособие «Латинский язык. LEGE ARTIS» предназначен для освоения основной образовательной программы высшего профессионального образования 33.05.01 «Фармация». Цель учебного пособия: обучение грамотному овладению латинской фармацевтической терминологией и практическому применению в профессиональной сфере деятельности. Пособие состоит из трех модулей – грамматического, химического и клинического. Каждый модуль содержит теоретический блок, упражнения на закрепление материала и лексический минимум с учётом специфики каждого раздела. В целях облегчения усвоения наиболее трудных тем часть теоретического материала представлена в таблицах, алгоритмах и моделях, что способствует наиболее эффективному усвоению материала. Теоретический блок модуля сопровождается системой упражнений с варьированием заданий и многократным повторением изучаемых терминов. В упражнениях используется метод поэтапного усложнения – от простейших терминов до самых сложных предложений. Такой подход позволяет отработать навык перевода терминов и предложений любой степени сложности. В конце каждого модуля предлагается образец билета, который наглядно отражает структуру необходимых знаний по модулю, дает возможность проверить свои знания. Кроме лексико-грамматического материала, в пособии представлены Приложения в – названия фармацевтических групп, частотных отрезков ЛС, фармацевтических фразеологизмов, аббревиатур и др., а также корпус крылатых латинских изречений, темы рефератов.