bluuebunny/crossref_metadata_2025 huggingface dataset:
An Analysis of Students’ Perceptions on Google Classroom Media Used By English Teachers during Pandemic Covid-19
Authors: Riswanto Riswanto
Published: January 2023

Online learning or virtual classrooms use technology to help students and teachers with distance learning, with teachers providing accessible teaching materials. The purpose of this study is to describe students' perceived convenience and usefulness of Google Classroom material. This was a quantitative research that used a Likert Scale questionnaire. This study focuses on XI IPS students at SMAN 8 Bengkulu. To estimate the proportion of students' scores, data was analyzed using Sudjana's provided algorithm. The results suggest that around 79 percent, or more than half of the students, find it easy to study by utilizing Google Classroom since it offers an easy operating system and features that are simple to comprehend. Overall, based on the result of the research, there was more than half of the total demonstrated positive perceptions.
The Effectiveness Of The Descriptive Statistics Module In Online Learning In Computerized Accounting Study Program, Banjarmasin State Polytechnic
Authors: Priyougie Priyougie , Haq Ahsanul , Rusniati Rusniati , Bahit Muhammad
Published: January 2023

Module is considered important in distance learning as a self-study guide for students. The importance of module in the learning process because modules can facilitate students in learning independently or face to face. Based on several explanations regarding the importance of modules in distance learning, the authors are interested in examine the effectiveness of using the descriptive Statistics Module in Online Learning in the Computerized Accounting Study Program, Banjarmasin State Polytechnic. The variables observed by the authors in this study were the learning outcomes of groups of students who were given a module and those who were not given a module in descriptive statistics courses. The two variables were carried out a Normality Test with the purpose of assessing the distribution of data in groups of data or variables, whether the data distribution was normally distributed. From the results of the data normality test, a test of the assumption of homogeneity of variance was then carried out to determine the variance of several populations was the same or not. Then a difference test was carried out to test the differences in the group of students who were given the module and the group of students who were not given the module in learning descriptive statistics courses. The data normality test was carried out using the SPSS Kolmogorov Smirnov Test application on the learning outcomes data for descriptive statistics courses for students who were given a module and those who were not given a module yielded a significance value of 0.101. The significance value of 0.101 was greater than 0.05 so it can be concluded that the research data met the assumption of normality. The homogeneity of variance test was carried out by analyzing the significance value of Levene's Test for Equality of Variance where the significance result was 0.466 so it can be concluded that the data had a homogeneous variance. The final stage of this analysis is to test the difference between the learning outcomes data of student groups who were given modules and not given modules by using the Independent Sample t Test. The test results showed a significance value of 0.021 where the significance value was less than 0.05. Thus it can be concluded that the alternative hypothesis (H1) that states that "There is a significant difference between the learning outcomes of groups of students who are given a module and not given a module" can be accepted and verified statistically.
A Quantitative Examination of Vocal Fold Vibratory Changes Using Two-Dimensional Scanning Digital Kymography After Angiolytic Laser Stripping for Vocal Fold Leukoplakia
Authors: Choi Jihoon , Lee Seung Jin , Chae Hye Rim , Kang Min Seok , Park Young Min , Wang Soo-Geun , Lim Jae-Yol
Published: January 2023

Background and Objectives Vocal fold leukoplakia is characterized as white plaque on the epithelium of the vocal folds and can be treated by angiolytic laser stripping surgery. However, postoperative changes in the vibratory patterns of vocal folds have not been investigated quantitatively. The purpose of this study was to investigate the changes in vocal fold vibration after angiolytic laser surgery in patients with unilateral vocal fold leukoplakia using the twodimensional scanning digital kymography (2D DKG).Subjects and Method Medical records of seven males (age=62.14±12.40 yrs) with unilateral vocal fold leukoplakia who underwent angiolytic laser stripping were reviewed. Before and after the surgery (post-operative day=82.57±28.55 days), a multi-dimensional voice assessment was performed along with a 2D DKG study. For 2D DKG images, the amplitude symmetry index (ASI), phase symmetry index (PSI), and open quotient (OQ) were calculated using the ImageJ program. In addition, pre- versus postoperative data were compared, and the correlation between the changes in 2D DKG parameters and voice outcomes was explored.Results Results indicated that the absolute ASI (p=0.028) and OQ (p=0.028) of the 2D DKG study, grade (p=0.038) and breathy (p=0.034) of the GRBAS scale, σPitch measured by the electroglottography (p=0.043), the physical score of the VHI (p=0.042), and the total score (p=0.043) and the tiredness score (p=0.043) of the VFI decreased after surgery. Decrease in the absolute ASI was correlated with changes in the grade (rho=0.850) and breathy (rho=0.777) scale measures, while decreased OQ were correlated with the changes in the physical score of the VHI (rho=0.901) and tiredness score of the VFI (rho=0.847).Conclusion The improved vocal fold vibratory patterns after angiolytic laser surgery for vocal fold leukoplakia can be evaluated objectively using the 2D DKG study. Angiolytic laser stripping enables the preservation of vocal fold vibration after the surgery and is considered a valuable surgical option for treating vocal fold leukoplakia.
O impacto da COVID-19 na formação do cirurgião bucomaxilofacial
Authors: Vidal Iago Barbosa , Benevides Breno Souza , Aguiar Dulce Maria de Lucena , Frota Gabriel Gouveia , Alcântara Maria Thayanne Duarte , Marques Paulo Leonardo Ponte
Published: January 2023

Cirurgiões-dentistas especialistas em Cirurgia e Traumatologia Buco-Maxilo-Facial (CTBMF) são formados em cenário hospitalar, exigência do processo de qualificação na área. Contudo, com o surgimento da COVID-19, e a rapidez de sua disseminação, houve a interrupção de variadas atividades na sociedade, com repercussões na formação profissional. Este estudo teve como objetivo analisar a percepção do residente em Cirurgia Bucomaxilofacial sobre o impacto do COVID-19 na sua formação. Pesquisa de abordagem qualitativa que teve como cenário quatro hospitais com residências em Cirurgia Bucomaxilofacial do município de Fortaleza-Ceará. Foram entrevistados 16 residentes, no segundo semestre de 2020, por um pesquisador treinado, utilizando-se um questionário semiestruturado que abordou questões sobre o impacto na formação, lacunas percebidas, mudanças atitudinais e repercussões psicossociais. As entrevistas foram gravadas, transcritas e posteriormente analisadas por meio da análise de conteúdo de Bardin, tomando-se por base os pressupostos da teoria da racionalidade limitada. Após leitura exaustiva, emergiram quatro categorias analíticas: mudanças no cotidiano; biossegurança e protocolos sanitários; impactos sociais e psicológicos; concordância nas atitudes gerenciais. Apesar da insatisfação, diante do cenário complexo e incerto, a virtualização foi a única alternativa casual para evitar maiores impactos na formação. Na percepção dos residentes houve perda significativa de atividades que prejudicaram no quesito técnico e psicológico, requerendo monitoramento gerencial, a fim de suprir esta lacuna na formação.
Cosméticos Verdes: revisão bibliográfica acerca da tendência sustentável no desenvolvimento de cosméticos
Authors: Mendonça Beatriz da Motta Ramos , Alves Priscila Elias , Santos Elisabete Pereira dos
Published: January 2023

O consumo de cosméticos tem adquirido novas vertentes de acordo com o progresso social e científico e o consequente maior acesso à informação. A busca por um estilo de vida sustentável formou o “consumidor verde”, responsável por estimular o reposicionamento de empresas em relação à formulação de produtos de beleza e a aplicação da sustentabilidade em seus modelos de produção, o que propiciou a criação dos “cosméticos verdes”, -que engloba os cosméticos orgânicos, naturais e veganos. O objetivo central deste trabalho foi realizar uma revisão sistemática da literatura acerca da tendência sustentável no desenvolvimento de cosméticos, considerando a utilização de ativos naturais na formulação de produtos e os desafios decorrentes do desenvolvimento de cosméticos e embalagens de forma sustentável; questões relativas à legislação e certificação desses produtos e o comportamento das empresas na execução de estratégias competitivas para acompanhar esse movimento. Para isso, a pesquisa foi realizada conforme as palavras-chaves em bancos de dados como Scielo, PubMed, ResearchGate e Google Acadêmico, além de publicações em periódicos relevantes do segmento de interesse. Com base nos dados apresentados neste estudo, evidencia-se que a considerada tendência se tornou uma prática sólida no setor de beleza, originando um mercado preocupado com seu desempenho ambiental frente aos novos desejos da sociedade; ainda assim, por permanecer em constante evolução, assim como seus consumidores, essa prática apresenta alguns obstáculos expressivos, fazendo-se necessária uma análise crítica a partir das considerações expostas.
Diagnósticos de enfermagem para pacientes críticos com COVID-19 em Unidade de Terapia Intensiva: revisão de literatura
Authors: Santos José Luís Silva dos , Oliveira Daniele Mendes de , Serafim Clarice Souza , Freitas Lucas Ribeiro de , Nascimento Aline Souza Terra , Viturino Matheus Gabriel da Silva Cavalcanti , Neves Giselda Bezerra Correia , Silva Maria Dayane Apolinario da , Portugal Wanuska Munique , Amorim Neto Paulo Dias de
Published: January 2023

Objetivo: Investigar os principais Diagnósticos de Enfermagem relacionados aos pacientes críticos com COVID-19 em Unidade de Terapia Intensiva. Metodologia: Revisão integrativa, as buscas foram realizadas nos meses de fevereiro a novembro de 2022 nas bases de dados: LILACS, MEDLINE, BDENF, SciELO, BVS, Cochrane Library e Google Acadêmico. Foram selecionados 48 estudos para leitura na integra, no qual foram excluídos 34, por não corresponderem aos objetivos da pesquisa. Por fim, o corpus da revisão foi composto por 14 artigos. Resultados: Foi elencado 53 Diagnósticos de Enfermagem para pacientes críticos com COVID-19 em UTI, os mais prevalentes evidenciado nesta revisão foram: Déficit no autocuidado para alimentação; Déficit no autocuidado para banho; Padrão respiratório ineficaz; Risco de glicemia instável; Risco de infecção; Risco de lesão por pressão; Troca de gases prejudicada e Ventilação espontânea prejudicada. Considerações Finais: Os cuidados de enfermagem alicerçado ao Processo de Enfermagem por meio da elaboração dos diagnósticos de enfermagem, favorece uma efetiva atuação dos profissionais de Enfermagem, além de contribuir para a análise crítica sobre as condições de saúde do cliente.
The role of different viral biomarkers on the management of chronic hepatitis B
Authors: Mak Lung-Yi , Hui Rex Wan-Hin , Fung James , Seto Wai Kay , Yuen Man-Fung
Published: January 2023

Chronic hepatitis B infection is a major public health challenge. With the advancement in technology, various components of the viral cycle can now be measured in the blood to assess viral activity. In this review article, we summarize the relevant data of how antiviral therapies impact viral biomarkers, and discuss their potential implications. Viral nucleic acids including hepatitis B virus (HBV) double-stranded deoxy-ribonucleic acid (DNA) and to a lesser extent, pre-genomic RNA, are readily suppressed by nucleos(t)ide analogues (NUCs). The primary role of these markers include risk prediction for hepatocellular carcinoma (HCC) and risk stratification for partial cure, defined as off-therapy virological control, or functional cure, defined as hepatitis B surface antigen (HBsAg) seroclearance plus undetectable serum HBV DNA for ≥6 months. Viral translational products including hepatitis e antigen, quantitative HBsAg and hepatitis B core-related antigen can be reduced by NUCs and pegylated interferon a. They are important in defining disease phase, delineating treatment endpoints, and predicting clinical outcomes including HCC risk and partial/ functional cure. As the primary outcome of phase III trials in chronic hepatitis B is set as HBsAg seroclearance, appropriate viral biomarkers can potentially inform the efficacy of novel compounds. Early viral biomarker response can help with prioritization of subjects into clinical trials. However, standardization and validation studies would be crucial before viral biomarkers can be broadly implemented in clinical use.
ДО МЕТОДОЛОГІЇ ПРАВОЗНАВЧОГО ДОСЛІДЖЕННЯ РОСІЙСЬКОЇ АГРЕСІЇ ЯК ЦИВІЛІЗАЦІЙНОГО КОНФЛІКТУ
Authors: Комарницький В. М. , Литвинов О. М.
Published: January 2023

Черговий напад московських урядовців та їхніх підневільних підлеглих на українські землі вимагають розуміння не тільки поточних питань політичного взаємоіснування, а й осмислення світоглядних засад взаємодії суспільств та етносів, які історично сформувалися в доволі відмінних умовах. Тому пропонуємо варіант сáме методологічного підходу до з’ясування меж взаємопорозуміння, котре спирається на культурно-цивілізаційні підмурки, що не є переобтяженими загальним імперським історичним досвідом нерівноправ’я за національною ознакою. Частина правосвідомості в історичній свідомості представників цивілізацій різного рівня культурного розвитку стає визначальною для майбутнього, де культурна, тобто суто людська складова в структурі особистості, приймається через ідею прав людини. Інший світ, світ «людей минулого» («російський світ»), що є в координатах сучасності фактично злочинним, демонструє свої тваринні основи через звірячі форми агресивності. Погодження з цим, а тим більше підтримка такої світоглядної позиції частиною населення України є рудиментом радянських та імперських часів цілеспрямованого й безальтернативно інтенсивного політико-правового втілення культурного примітивізму східних деспотій. Тому питання методології осмислення сучасних подій видаються визначальними, оскільки всі інші стають похідними.
КОНЦЕПЦІЯ АНОМІЇ В КРИМІНОЛОГІЇ: ТЕОРЕТИЧНІ ТА ПРИКЛАДНІ АСПЕКТИ
Authors: Денисов С. Ф. , Тимчук О. Л.
Published: January 2023

У концепції Е. Дюркгайма аномія означає такий стан суспільства, при якому стара ієрархія цінностей зруйнована, а нова не виникла або не може закріпитися. Тобто аномія виникає тоді, коли в певній сфері суспільного життя немає загальноприйнятих стандартів, які б регулювали поведінку індивідів. Аномія як прояв соціальної дезорганізації є джерелом злочинності, самогубств та інших девіацій. Наголошено на тому, що саме теорія Е. Дюркгайма заклала основу для вивчення феномену аномії. Подальший розвиток концепції аномії пов'язаний з американським соціологом Р. Мертоном. На відміну від Е. Дюркгайма, Р. Мертон розглядав аномію як результат конфлікту між «культурою» і «соціальними структурами». Аномія виражає такий розпад у культурній структурі, коли існує гостре розходження між культурними нормами та соціально схваленими можливостями людей, як членів певних груп, діяти згідно з цими культурними нормами. Прихильники інституціональної теорії аномії висунули гіпотезу, згідно з якою надмірний акцент на економічних цілях, сукупно з девальвацією неекономічних інститутів в суспільстві, призводить до зростання злочинності. У статті проаналізована специфіка аномії в перехідних суспільствах, включаючи Україну. Охарактеризовані емпіричні індикатори аномії в сучасному світі. Наголошено на тому, що найбільш важливими індикаторами соціальної аномії в її дюркгаймівській версії є умисні вбивства, самогубства та корупція. Індекс умисних вбивств та індекс самогубств у сукупності складає індекс насильства, який характеризує масштаби соціальної патології. За індексом насильства найгірша у світі ситуація фіксується в Лесото, ПАР та Гайані. Мінімальна соціальна патологія в трьох державах Азії – це в Індонезії, Йорданії та Брунеї. Найнижча корупція – у західних державах та окремих країнах Східної та Південно-Східної Азії, а найвища – у деяких мусульманських та африканських. Ситуація в Україні є складною як за індексом насильства, так і за індексом корупції.
Gümüşhane’deki Kadın Çalışanların İş Yerleri ve İle Dair Afet ve Acil Durum Algı Düzeyleri
Authors: Yildiz Eyyüp , Çakır Sena , Demir Veysi , Ayaz Pınar
Published: January 2023

Kadınların afetler karşısında daha savunmasız oldukları birçok akademik çalışmada belirtilmiştir. Bu yüzden, kadınların bulunduğu her alanda, onların afetlere ilişkin bilgi, farkındalık, hazırlık ve risk algısı düzeylerinin tespit edilmesi önemlidir. Bu çalışma Gümüşhane il merkezinde çalışan kadınların çalıştıkları iş yerlerinin ve yaşadıkları ilin afetlere ne düzeyde hazır olduklarına dair algılarını tespite yönelik yapıldı. Bu doğrultuda, araştırmaya katılımı kabul eden 94 (2 anket veri setinden çıkarılmıştır.) kadın çalışana anket (kâğıt anket) uygulandı. Veriler SPSS (23) yazılımında analiz edildi. Katılımcıların %69,6’sını 18-28 yaş aralığındaki gençlerden, %73,9’u bekarlardan oluşurken, %78,3’ünün çocuğu yoktur. Yanıt ortalamalarına göre Gümüşhane il yönetiminin afet sonrası ihtiyaçları karşılayacağına olan inanç (2,51) genel ortalamanın (2,9) altındadır. Buna paralel kadercilik tutumları da ortalamanın altında (2,14) yer almıştır. Katılımcıların afetler konusunda kaderci bir tavır takınmamaları afet yönetimi açısından olumlu iken, il yöneticilerine karşı güvensiz tutumları dikkate değerdir. Bu yüzden il idaresinin gelecekteki afetlere yönelik aldıkları tedbirleri ve yapacakları yardımları kadın çalışanlara anlatmaları önerilir.
Dos rabiscos, traços e cores: perspectivas históricas através das animações cinematográficas
Authors: Souza Thaís Vieira Silva de , Menezes Luiz Maurício Bentim da Rocha
Published: January 2023

O presente artigo analisa dois filmes do cinema brasileiro do nicho animado em que as cores e traços determinam posições, bem como, a historicidade de seus personagens, maneira na qual diretores e roteiristas se utilizam do lúdico para expor determinadas mazelas sociais. Desta forma, busca-se relacionar os contextos socioeconômicos e raciais com os aspectos técnicos das produções.
A concepção de lugar sagrado: o caso da comunidade paraense Alvorecer da Esperança
Authors: Rodrigues Donizete , Pimentel Gracileno Trindade
Published: January 2023

Este trabalho faz parte de um estudo etnográfico da Comunidade Alvorecer da Esperança, localizada na zona rural de Abaetetuba (Pará). Tendo como suporte teórico de interpretação da realidade social autores como Durkheim, Eliade, Tillich e Otto, a metodologia adotada foi a qualitativa, mais observação (sociológica) do que participação (antropológica), focando nas entrevistas com os líderes e alguns moradores locais. O trabalho procura responder como definem e entendem o sagrado, ou seja, qual o lugar no espaço e no tempo que essa comunidade religiosa considera como sendo sagrado? A partir dessa questão central, buscamos compreender quais os critérios utilizados para definir “o lugar sagrado” e os motivos para identificar outros como não sagrados. Como resultado, pode-se afirmar que o lugar sagrado não está relacionado ao templo ou qualquer outra infraestrutura físico-espacial, mas efetua-se em qualquer espaço e momento em que o grupo se reúne para realizar uma prática religiosa.
“Dos judíos, tres discusiones, cuatro sinagogas”: etnografía en familias y comunidades judías de Buenos Aires
Authors: Zaros Agustina Adela
Published: January 2023

Este texto surge de tres momentos del campo etnográfico relativo al proceso de adquisición de roles y posicionamientos tanto del investigador como de los actores, como individuos o como pertenecientes a determinados grupos. Reflexiona sobre cómo se produce ese movimiento en el campo que configura sus identidades en diferentes circunstancias, de manera relacional. La metodología es cualitativa con etnografía en familias y comunidades judías de Buenos Aires realizado entre 2016 y 2019. Familia e instituciones religiosas son los espacios de socialización de estas comunidades y los agentes de transmisión de la memoria de la tradición religiosa y de su interpretación en el presente. El proceso de recolección de datos permitió relevar diferentes memorias que caben en la diversidad de los espacios judíos de Buenos Aires a partir de los accesos simultáneos a diferentes experiencias de la vida familiar y comunitaria.
Las fiestas patronales de San Miguel Arcángel: las identidades político-religiosas salen a la calle
Authors: Cremonte Juan Pablo
Published: January 2023

El presente trabajo aborda una serie de observaciones preliminares sobre las fiestas patronales de San Miguel Arcángel que se realizan todos los años en septiembre en la municipalidad de San Miguel, Provincia de Buenos Aires. El municipio mencionado, a partir de 2012 tomó la organización de las fiestas patronales como una instancia en la que canalizar una serie de identidades político-religiosas que fueron sumando adhesiones, por un lado, y ampliando y profundizando ciertos rasgos identitarios, por el otro. El objeto de este trabajo es puntualizar los rasgos centrales de esas celebraciones y formular una serie de interrogantes en torno a las características culturales que señala la mencionada celebración respecto de la comunidad que le da abrigo. Este artículo se elaboró a partir de una etnografía en las ediciones de las fiestas patronales de San Miguel Arcángel y una serie de entrevistas a sus organizadores.
EFFECT OF INVENTORY TURNOVER AND LIQUIDITY ON PROFIT IN PT SGEEDE SOLUSI TEKNOLOGI DECLINED CURRENTLY IN THE DECLINED STAGE
Authors: Wangdra Ronald , Effendi Syahril
Published: January 2023

This research aims to determine the impact of inventory turnover and liquidity on the earnings of PT Sgeede Solusi Teknologi from 2018 to 2022. The R Square test results of this study show that 20.8% of the profit can be explained by inventory turnover and liquidity variables, while the remaining 29.2% is explained by other variables not found in the study. The results of the t-test showed that the number of inventories - that < -table or -2.299 < -2.002 and 0.025 < 0.05 significant level, which means that partial inventory turnover has a significant negative effect on profit. Similarly, with the results of t-test of liquidity variable which is 3.159 and significant level of 0.001 <0.05. It means that inventory turnover has a significant negative effect on profit.
Recent advances in bio-inspired ionic liquid-based interfacial materials from preparation to application
Authors: Zhang Zhe , Zhao Ran , Wang Shutao , Meng Jingxin
Published: January 2023

Natural creatures always display unique and charming functions, such as the adhesion of mussels and the lubrication of Nepenthes, to maintain their life activities. Bio-inspired interfacial materials infused with liquid, especially for ionic liquids (ILs), have been designed and prepared to meet the emerging and rising needs of human beings. In this review, we first summarize the recent development of bio-inspired IL-based interfacial materials (BILIMs), ranging from the synthesis strategy to the design principle. Then, we discuss the advanced applications of BILIMs from anti-adhesive aspects (e.g., anti-biofouling, anti-liquid fouling, and anti-solid fouling) to adhesive aspects (e.g., biological sensor, adhesive tape, and wound dressing). Finally, the current limitations and future prospects of BILIMs are provided to feed the actual needs.
Clinical phase I/II trial of SVF therapy for cartilage regeneration: A cellular therapy with novel 3D MRI imaging for evaluating chondral defect of knee osteoarthritis
Authors: Ren Bin , Chang Yiqiang , Liu Ruolan , Xiao Feng , Xu Jun , Li Lingsong , Li Tao , Ruan Zhao , Bao Yigui , Lin Junbing , Zhou Junying , Liao Weijing , Pan Zhenyu , Xu Haibo , Tian Jun , Cai Lin , Zheng Xin Xiao
Published: January 2023

Background: The clinical applications of stromal vascular fraction (SVF) therapy for osteoarthritis (OA) have attracted academic and clinical attention. However, data of the effects of stromal vascular fraction therapy on regeneration of degenerated cartilage are limited in the literature. Meanwhile, there is a great need for a simple and non-invasive evaluation method to analyze the changes of joint cartilage qualitatively and quantitatively in clinical trials. This study entitled “stromal vascular fraction Therapy for Human Knee Osteoarthritis” was registered in ClinicalTrial.gov # NCT05019378.

Materials and Methods: We designed and conducted a single center, open labeled clinical phase I/II study, and 6 osteoarthritis patients with both knee cartilage defect I-II were enrolled in this study. The two knees of each patient were randomly assigned to autologous stromal vascular fraction treatment group or non-treatment control group to evaluate the safety and therapeutic effect of stromal vascular fraction therapy for human knee osteoarthritis. We have also established a novel protocol to provide 3D MRI imaging for human knee cartilage enabling us to qualitatively and quantitatively evaluate cartilage degeneration and regeneration in this study.

Results: The qualitative and quantitative evaluation of 3D Magnetic Resonance Imaging (MRI) imaging of knee cartilage demonstrated that the stromal vascular fraction therapy reduced the cartilage defects; and significant increase of cartilage value both in defect cartilage area and whole cartilage area of treated group and significant increase of thickness and area of both femoral and tibia cartilage in vertical sections of the stromal vascular fraction treated Group at 12 and 24 W post treatment in cartilage defect I-II osteoarthritis patients.

Conclusion: This clinical phase I/II study indicated that stromal vascular fraction therapy is a safe clinical procedure and provided evidence that the stromal vascular fraction therapy significantly facilitated cartilage regeneration, opening the opportunity to a phase III trial investigating authentic efficacy of the procedure. This study is the first qualitative and quantitative evaluation of the efficacy of autologous stromal vascular fraction cellular therapy on cartilage regeneration. Through early and definite diagnosis of knee osteoarthritis patients, and providing safe and efficient therapy to facilitate cartilage regeneration, we will be able to control or reverse cartilage degeneration and completely change the epidemiology of osteoarthritis worldwide.
Two new species of Hymenochaetaceae from tropical Asia and America
Authors: Zhou Meng , Ji Xiao-Hong , Liu Hong-Gao , Miller Kurt , Yuan Yuan , Vlasák Josef
Published: January 2023

Two new species in Hymenochaetaceae, Fulvifomes acaciae and Pyrrhoderma nigra, are illustrated and described from tropical Asia and America based on morphology and phylogenetic analyses. F. acaciae is characterized by perennial, pileate, and woody hard basidiomata when fresh; ash gray to dark gray, encrusted, concentrically sulcate, and irregularly cracked pileal surface; circular pores of 7–8 per mm with entire dissepiments; a dimitic hyphal system in trama and context; absence of setal element and presence of cystidioles; and broadly ellipsoid, yellowish brown, thick-walled, and smooth basidiospores measuring 5–6 μm × 4–5 μm. P. nigra is characterized by perennial and resupinate basidiomata with dark gray to almost black pore surface when fresh; small and circular pores of 7–9 per mm, a monomitic hyphal system with generative hyphae simple septate, hyphoid setae dominant in subiculum but not in tube trama, and absence of cystidia; and ellipsoid, hyaline, thin-walled basidiospores measuring 4–5 μm × 3–3.6 μm. The differences between the new species and morphologically similar and phylogenetically related species are discussed. Keys to Fulvifomes and Pyrrhoderma have also been provided.
Application of the ultrasound-guided double-screen contrast method in the standardized teaching and training of resident doctors in femoral vein puncture
Authors: Zhang Yunshui , Li Jin , Sun Yaying , Liu Tao , Guo Wenmin , Ban Weiwei , Ma Yujie
Published: January 2023

Objective

The aim of this study was to investigate the advantages of the double-screen contrast method compared with the short-axis ultrasound display method for teaching ultrasound-guided femoral vein puncture during the standardized training of resident doctors.

Methods

Sixty resident doctors undergoing standardized training were randomly divided into a test group (short–long axis switching double-screen contrast, n = 30) and a control group (n = 30). These two groups of physicians underwent teaching and training of ultrasound-guided femoral vein puncture, and the success rate of the first puncture attempt, the total catheterization time, and any accidental femoral artery punctures were recorded and compared between the two groups.

Results

The success rate of the first puncture attempt in the test group was significantly higher than that in the control group (P < 0.05). In the control group, two doctors accidentally punctured the artery, while in the test group, no arterial punctures occurred. The puncture time for the test group was longer than for the control group (P < 0.05).

Conclusion

In the standardized training of ultrasound-guided femoral vein puncture for resident doctors, the double-screen contrast method has significant advantages. It enables resident doctors to quickly understand and apply the technique, so it is worth making this the method of choice.
Changing trends of the disease burden of non-rheumatic valvular heart disease in China from 1990 to 2019 and its predictions: Findings from global burden of disease study
Authors: Zheng Xiaoxin , Guan Qing , Lin Xiuquan
Published: January 2023

Objective

China has an increasing burden of non-rheumatic valvular heart disease (NRVHD) as the aging of the population is deepening. The aim was to assess the age and sex-specific prevalence and DALYs of NRVHD in China from 1990 to 2019 and to predict the burden in the next 25 years.

Methods

The Global Burden of Disease Study (2019) was used to extract the data of age- and sex-specific incidence, mortality, and disability-adjusted life years (DALYs) of NRVHD in China, 1990-2019. We estimated the annual percentage change (EAPC) to access the temporal trends of the disease burden of NRVHD. The R package called Nordpred was used to perform an age-period-cohort analysis to predict the prevalence of NRVHD in the next 25 years.

Results

The number of incident cases of NRVHD increased from 93.16 thousand in 1990 to 325.05 thousand in 2019. Overall upward trends were observed in the age-standardized incidence rate (ASIR) from 1990 to 2019. Significant temporal trends in mortality and DALYs of NRVHD were observed. High systolic blood pressure, high sodium diet, and lead exposure were the main driving forces for NRVHD. In the next 25 years, the number of new cases and deaths of NRVHD should continue to increase to 390.64 thousand and 10.0 thousand, respectively. The ASIR should show an upward trend, while the ASMR should show a downward trend among men and women.

Conclusion

In China, the overall rates of NRVHD have increased over the past 30 years, and there has been a substantial increase in the burden of NRVHD due to population growth and aging and will continue to increase in the next 25 years. Our results can help shape a multifactorial approach and public policy to reduce the NRVHD burden throughout China.
Strength model of a cemented body based on self-compacting characteristics of tailings
Authors: Jun Wang , Tian-Yu Yang , Deng-Pan Qiao , Jie Chen , Zheng-Liang Luo
Published: January 2023

To examine the strength and mechanical characteristics of self-compacting tailings, a direct shear test was conducted under various consolidation states and moisture contents to determine the cohesion and internal friction angle of the tailings. The degree of cohesion and the internal friction angle of unsaturated tailings increased initially before declining as the moisture content rose. The maximum cohesion and internal friction angle were reached when the moisture content was around 14%. When combined with the Coulomb shear strength formula and the tailings self-weight compaction model, the expressions for the active pressure and passive pressure of tailings at any height on the lateral restraint were obtained. An improvement in cohesion and the internal friction angle of unsaturated tailings was seen with increased consolidation stress, which became stable when the consolidation stress was greater than 1 MPa. The limited equilibrium method was used to establish the three-dimensional mechanical equilibrium of the cemented body. A strength model of cementation at the open stoping stage with subsequent filling was developed after the three-dimensional strength analytical model of cementation in step 1 was modified. The difference between the design value and the measured value was 0.2 MPa. The strength of the one-step cemented backfill design, as well as the design and erection of the backfill retaining wall, was supported technically and theoretically by this study.
The association of alanine aminotransferase and diabetic microvascular complications: A Mendelian randomization study
Authors: Bi Yaru , Liu Yanjing , Wang Heyuan , Tian Suyan , Sun Chenglin
Published: January 2023

Aims

Alanine aminotransferase (ALT) is positively related to diabetes risk in observational studies, whereas Mendelian randomization supports a linear causal association. In contrast, the relationship between ALT and diabetic nephropathy, and diabetic retinopathy is counter-intuitive in observational studies. Furthermore, no MR study has examined their causal association. The study aimed to investigate whether genetically determined ALT has a causal effect on diabetic nephropathy and diabetic retinopathy.

Methods

Genetic instruments associated with ALT (P < 5×10-8) were obtained from a recent genome-wide association study (GWAS) that included 437,267 individuals of European ancestry. Summary data of diabetic microvascular complications were derived from the FinnGen study (3,283 cases and 181,704 controls for diabetic nephropathy, and 14,584 cases and 176,010 controls for diabetic retinopathy, both were of European ancestry). Effect estimation and pleiotropy testing were performed using inverse variance weighted (IVW), MR-Egger regression, weighted median, and mode-based estimator methods. We additionally performed sensitivity analysis excluding proxy single nucleotide polymorphisms (SNPs) or lowering the GWAS significance threshold (P < 5×10-7) to test the robustness of the results.

Results

Based on IVW, a 2-fold increase in genetically determined ALT level was positively associated with diabetic nephropathy (odd ratio, [95% confidence interval], 1.73 [1.26-2.37], P = 0.001) and diabetic retinopathy (1.29 [1.08-1.54], P = 0.005), but a null causal association in three pleiotropy robust methods, namely, MR-Egger, weighted median and mode-based estimator. We obtained similar results in the sensitivity analysis of excluding proxy SNPs or lowering the GWAS significance threshold.

Conclusions

With caution, we concluded that ALT plays no linear causal role in developing both diabetic nephropathy and diabetic retinopathy. Further investigations are required to test the hypothesis of a non-linear causal association.
A data-driven hybrid interval reactive power optimization based on the security limits method and improved particle swarm optimization
Authors: Chen Dawen , Qu Shaoqing , Liu Qian , Xiao Wei , Liu Xiao , Luo Yufeng , Yang Huaizhi , Kuang Na
Published: January 2023

The integration of renewable power generation introduces randomness and uncertainties in power systems, and the reactive power optimization with interval uncertainty (RPOIU) problem has been constructed to acquire the voltage control strategy. However, the large amount of uncertain data and the coexistence of discrete and continuous control variables increase the difficulty of solving the RPOIU problem. This paper proposes a data-driven hybrid interval reactive power optimization based on the security limits method (SLM) and the improved particle swarm optimization (IPSO) to solve the RPOIU problem. In this method, the large amount of historical uncertain data is processed by data-driven to obtain the boundary of optimal uncertainty set. The control variable optimization is decomposed into continuous variable optimization and discrete variable optimization. The continuous variables are optimized by applying the SLM with the discrete variables fixed, and the discrete variables are optimized by the IPSO with the continuous variables fixed. The two processes are applied alternately, and the values of the control variables obtained by each method are used as the fixed variables of the other method. Based on simulations carried out for the IEEE 30-bus system with three optimization methods, we verified that the voltage control strategy obtained by the data-driven hybrid optimization could ensure that the state variable intervals satisfied the constraints. Meanwhile, the values of the real power losses obtained by the proposed method were smaller than those obtained by the SLM and IPSO. The simulation results demonstrated the effectiveness and value of the proposed method.
The coordinated operation strategy of multi-type power generations in different modes in prosumer with high renewables
Authors: Hu Xuekai , Meng Liang , Su Can
Published: January 2023

The renewable energy with distributed generation is widely used because of the cleanliness and sustainability. However, when high renewables connect to the grid, the randomness and intermittent of the renewable energy will deteriorate the performance. As the important interface between distributed generations and power grid, the prosumer can contribute to the improvement of the renewable energy penetration if stable and reliable operation of the power supply is realized. The prosumer has multi-type generations, loads and auxiliary converters, where the characteristics interact each other. Moreover, due to the complicated grid states, the prosumer may operate in different conditions. Therefore, the research on the coordinated operation control strategy of the multiple electrical facilities is necessary in the prosumer with high renewables. In this paper, the AC/DC hybrid prosumer is established with multi-type distributed generations, loads and auxiliary converters. The prosumer can operate in normal grid-connected mode and grid-fluctuation mode. In different modes, the cooperation control of the power converter in the prosumer is proposed, which changes according to the grid demands. When over-limited grid voltage and frequency fluctuation are detected in the point of common coupling, the prosumer can switch from normal grid-connected mode to grid-fluctuation mode to provide voltage and frequency support. Finally, the simulation results based on Matlab/Simulink is employed to verify the effectiveness of the proposed control strategy.
Has the development of the digital economy improved green total factor productivity in China?—A study based on data at the provincial level in China
Authors: Wang Shijin , Xue Zhichao
Published: January 2023

China's economic development has entered a new historical stage, and it is crucial to coordinate the linkage between economic development, resource allocation and environmental protection in this new stage. In view of this, this paper selects the panel data of 30 provinces (municipalities and autonomous regions) in China from 2011 to 2020, and firstly measures the Green Total Factor Productivity (GTFP) by using Slack Based Measure -Malmquist Luenberger method (SBM-ML); Then, the relationship between the development of digital economy and regional GTFP is analyzed by using the two-way fixed effect model and threshold effect; Finally, relevant policy suggestions are put forward. This paper found that: firstly, the development of digital economy significantly improves China's GTFP, and the conclusion still valid after considering a series of robustness tests; Secondly, there are obvious disparities in the development level of digital economy among provinces, and the development level of coastal areas is generally higher than that of inland areas, and according to the sub-regional regression results, the positive effect of digital economy on GTFP has regional heterogeneity, and the development of digital economy in coastal areas has a more significant effect on the enhancement of GTFP, while this effect in inland areas does not pass the significance test; Thirdly, according to the threshold effect test results, there is also a single threshold effect with institutional environment and technological innovation as the threshold variables for the impact of digital economy on GTFP in China.
Provenance influences seed germination and phenotypic responses to water restriction in the endemic Beilschmiedia miersii (Gay) Kosterm
Authors: Magni Carlos R. , Poch Paola L. , Espinoza Sergio E. , Yáñez Marco A. , Martínez Eduardo E. , Promis Alvaro A. , Mancilla Gabriel A.
Published: January 2023

The higher drought intensity recorded in the last decades in the Mediterranean zone of Chile increased the level of threats of the endemic Beilschmiedia miersii (Gay) Kosterm and has raised concern about its capacity to face drought. In this study, we assessed the effect of seed provenance and mother tree on seed germination traits, seedling growth, biomass allocation, presence of cotyledons, and survival responses of B. miersii cultivated under two water treatments (well-watered versus water stress. Average pre-dawn plant water potentials of −0.9 and −4.5 MPa, respectively). The germination stage of this trial showed significant differences in germination capacity, germination energy, and the maximum value of Czabator. Provenances from the southern range of the species, with higher precipitation (Cantillana and El Arbol) had a better germination performance, however, once germinated, the ability of the seedlings to survive in the nursery was high only in two of the five provenances under study. The coastal and interior provenances with lower precipitations (El Pobre, Longotoma, and Antumapu) were not able to survive to the seedling stage (<5% survival). Seedling growth and survival varied significantly between the two remaining provenances and the two watering treatments. The provenance El Arbol, exhibited a higher survival, growth, presence of cotyledons, and biomass traits. This provenance also exhibited a higher presence of cotyledons in both watering treatments and an unaltered root to shoot ratio between the well-watered and the water stress treatments. Our results suggests that there is important phenotypic variation for seed germination and seedling survival associated to the provenance origin, emphasizing the importance of a nursery-evaluation phase before the beginning of restoration projects at the landscape level.
Understanding Crassostrea virginica tolerance of Perkinsus marinus through global gene expression analysis
Authors: Proestou Dina A. , Sullivan Mary E. , Lundgren Kathryn Markey , Ben-Horin Tal , Witkop Erin M. , Hart Keegan M.
Published: January 2023

Disease tolerance, a host’s ability to limit damage from a given parasite burden, is quantified by the relationship between pathogen load and host survival or reproduction. Dermo disease, caused by the protozoan parasite P. marinus, negatively impacts survival in both wild and cultured eastern oyster (C. virginica) populations. Resistance to P. marinus has been the focus of previous studies, but tolerance also has important consequences for disease management in cultured and wild populations. In this study we measured dermo tolerance and evaluated global expression patterns of two sensitive and two tolerant eastern oyster families experimentally challenged with distinct doses of P. marinus (0, 106, 107, and 108 parasite spores per gram wet weight, n = 3–5 individuals per family per dose). Weighted Gene Correlation Network Analysis (WGCNA) identified several modules correlated with increasing parasite dose/infection intensity, as well as phenotype. Modules positively correlated with dose included transcripts and enriched GO terms related to hemocyte activation and cell cycle activity. Additionally, these modules included G-protein coupled receptor, toll-like receptor, and tumor necrosis factor pathways, which are important for immune effector molecule and apoptosis activation. Increased metabolic activity was also positively correlated with treatment. The module negatively correlated with infection intensity was enriched with GO terms associated with normal cellular activity and growth, indicating a trade-off with increased immune response. The module positively correlated with the tolerant phenotype was enriched for transcripts associated with “programmed cell death” and contained a large number of tripartite motif-containing proteins. Differential expression analysis was also performed on the 108 dosed group using the most sensitive family as the comparison reference. Results were consistent with the network analysis, but signals for “programmed cell death” and serine protease inhibitors were stronger in one tolerant family than the other, suggesting that there are multiple avenues for disease tolerance. These results provide new insight for defining dermo response traits and have important implications for applying selective breeding for disease management.
Integrated analysis of mRNA and microRNA expression profiles in hepatopancreas of Litopenaeus vannamei under acute exposure to MC-LR
Authors: Zhang Dajuan , Huang Lanying , Jia Yingxuan , Zhang Shulin , Bi Xiandong , Dai Wei
Published: January 2023

Intensive shrimp farming is often threatened by microcystins Hepatopancreas is the primary target organ of MCs in shrimp. To investigate the response of hepatopancreas to acute MC-LR exposure, the expression profiles of RNA-seq and miRNA-seq in the hepatopancreas of L. vannamei were determined, and data integration analysis was performed at 72 h after MC-LR injection. The expression of 5 DEGs and three DEMs were detected by Quantitative PCR (qPCR). The results showed that the cumulative mortality rate of shrimp in MC-LR treatment group was 41.1%. A total of 1229 differentially expressed genes (844 up- and 385 down-regulated) and 86 differentially expressed miRNAs (40 up- and 46 down-regulated) were identified after MC-LR exposure. Functional analysis indicated that DEGs is mainly involved in the oxidative activity process in molecular functional categories, and proteasome was the most enriched KEGG pathway for mRNAs profile. According to the functional annotation of target genes of DEMs, protein binding was the most important term in the GO category, and protein processing in endoplasmic reticulum (ER) was the most enriched KEGG pathway. The regulatory network of miRNAs and DEGs involved in the pathway related to protein degradation in endoplasmic reticulum was constructed, and miR-181-5p regulated many genes in this pathway. The results of qPCR showed that there were significant differences in the expression of five DEGs and three DEMs, which might play an important role in the toxicity and hepatopancreas detoxification of MC-LR in shrimp. The results revealed that MC-LR exposure affected the degradation pathway of misfolded protein in ER of L. vannamei hepatopancreas, and miR-181-5p might play an important role in the effect of MC-LR on the degradation pathway of misfolded protein.