bluuebunny/crossref_metadata_2025 huggingface dataset:
MAPPING THE PRIORITIES: COMPARATIVE ANALYSIS OF EU AND US ECONOMIC ENGAGEMENT IN CENTRAL ASIA
Authors: Aikumbayeva L.A. , Kakenova Z.A.
Published: January 2025

Central Asia has increasingly become a focal point for both the European Union (EU) and the United States (US),each pursuing distinct yet overlapping objectives. This article presents a comparative analysis of the EU's and the US's economic engagement in Central Asia,with a particular focus on trade relations, foreign investments, and energy security. By examining key development projects such as the Trans-Caspian Corridor, the study evaluates the effectiveness, scope, and sustainability of their economic interactionsin the region. The analysis highlights both convergences anddivergences in their strategies, revealing how these engagements shape regional stability, economic growth, and political reforms. While both the EU and the US share theoverarching goal of fostering stability and development in Central Asia, their priorities and methodsdiffer. The EU’s approach, grounded in liberal internationalism, emphasizes soft power tools, including economic cooperation, infrastructure development,and democracy promotion through institutional support. On the other hand, the US follows a more realist approach, focusingon geopolitical competition, securing energy routes, and enhancing militarycooperation, particularly through frameworks like the C5+1 platform. This comparative study sheds light on the broader geopolitical implications of Western involvement in Central Asia and its long-term impact on the region’s evolving political and economic landscape.
ИНТЕРЕСЫ США В СТРАНАХ БОЛЬШОГО КАСПИЙСКОГО РЕГИОНА
Authors: Акимова Б. Ж. , Сейлхан А. , Тайшанова С.Т.
Published: January 2025

Статья освещает интересы Соединенных Штатов Америки в странах большого Каспийского региона, который включает в себя такие государства, как Казахстан, Туркменистан, Азербайджан,Ирани Россия.Новая стратегия США в Каспийском регионе, фокусирующаяся на переговорах о делимитации и правовом статусе Каспийского моря, стала ответом на стремительные геополитические и экономические изменения в регионе.Растущая активность западных нефтегазовых компаний, стремящихся к освоению богатых углеводородных ресурсов Каспия, и смена экономических приоритетов прикаспийских государств в сторону энергетической экспансии, привели к пересмотру подходов к регулированию использования морских ресурсов. Россия, стремясь максимизировать свой влияние и контроль над каспийскими запасами, предпочла перейти от многостороннего форматапереговоров к серии двусторонних соглашений, что вызвало немалоспоров.Американская стратегия, в свою очередь, стремится к более прозрачному и справедливомурегулированию использования ресурсов Каспия,в том числечерезпоощрение многосторонних переговоров ипрозрачностьв добыче и транспортировке углеводородов. США также заинтересованы в предотвращении монополизации каспийской энергетики одной страной или группой стран. С этой целью США активно способствуют развитиюинфраструктуры для транспортировки каспийской нефти и газа по альтернативным маршрутам,что способствует снижению зависимости от российскойинфраструктуры. Однако,задачаСША осложняется сложной геополитическойобстановкойв регионе, включая влияние Иранаи тенденциюк формированиюрегиональных блоков. Поэтому, аспекты американской политики вКаспийскомрегионечастовключают дипломатические усилияпо укреплению отношенийсприкаспийскими странами, чтобы обеспечить баланссил и предотвратить доминированиеодной державы
A Review of Glenn McGillivray's Actors, Audiences, and Emotions in the Eighteenth Century: Communities of Sentiment
Authors: Parsons Semane
Published: January 2025

A Review of Glen McGillivray's book Actors, Audiences, and Emotions in the Eighteenth Century: Communities of Sentiment (2023).
Platon un “Devlet (Politeia)”inde Totalitarizmin İzleri (The Traces of Totalitarism in Plato s “State (Politeia)”
Authors: DEĞİRMENCİOĞLU Burcu , GÜRSEL DÜĞMECİ Esin
Published: January 2025

Etimolojik bağlamında toptancı, mutlak bir iktidarı, devletin topyekun egemenliğini hedefleyen siyasi ideolojiyi ifade etmek için tercih edilen totalitarizm, kavramsal olarak ilk defa 1920’lerden sonra kullanılmaya başlamıştır. İktidarın bizzat elinde bulundurduğu bir takım araçlar vasıtasıyla hegemonya alanına total egemenliğin empoze edildiği, insanları, grupları, aileyi, çocukları, toplumu baştan aşağı dönüştürdüğü, homojenleştirdiği bir siyasi rejim olan totaliter bir sistem tasarımının ilk izlerine, Platon’un “Devlet (Politeia)”inde rastlamak mümkündür. Hocası Sokrates’in ölümünün ardından, Sokrates’i ölüme götüren yönetimi reddeden Platon, Sokrates’i ve onun gibileri baş tacı edecek ideal bir devletin nasıl kurulabileceği üzerine düşünmüştür. Bir siyasi program olmanın yanı sıra toplumu baştan aşağıya değiştirecek, dönüştürecek bir sosyal programı da içeren devlete dair bütüncül bir okuma yapılan Devlet isimli eserinde Platon, ideal devlet modelinin üzerine inşa edildiği totaliter ögeleri ortaya koymuştur. Söz konusu ögelerle ideal devlet tasarımını güçlendiren Platon, bir insan doğası kurgulamış ve bireyleri bu kurguya adapte edebilmek, uyumlaştırabilmek için çeşitli meşruiyet araçlarından faydalanmıştır. Eğitimden dine pek çok alanda ortaya koyduğu kurallar vasıtasıyla Platon sosyal hayatı baştan sona dizayn etmiş, görev ve disiplin ayrılıkları kesinleştirilmiş bir sistem tasarlamış, yarattığı “kapalı toplum”uyla totaliter sistemin ilk izlerini göz önüne sermiştir.
5237 Sayılı TCK da Nitelikli Hâllerin Şeriklere Geçişi Hususunda Bağlılık Kuralının Yeterliliği Tartışması
Authors: kılıç yusuf
Published: January 2025

İştirak hâlinde işlenen suçlarda şeriklerin sorumlu tutulması, 5237 sayılı Türk Ceza Kanunu’nun düzenlemesine göre, bağlılık kuralıyla mümkün olmaktadır. Bununla birlikte, Kanun’un 40’ıncı maddesinde yer alan bağlılık kuralı düzenlemesinde, nitelikli hâllerin suç ortaklarına geçişi konusunda nasıl bir yol izleneceği açıkça belirtilmemiştir. Türk Ceza Kanunu’na ilişkin Hükûmet Tasarısında, nitelikli hâllerin suç ortaklarına geçişini düzenleyen bir madde bulunmaktaydı. Ancak nitelikli hâllerin suç ortaklarına geçişiyle ilgili madde ilave etme fikrinin, bağlılık kuralının bilinmediği 19. yüzyıl hukuk zihniyetinin ürünü olduğu ifade edilerek tasarının ilgili hükmü kanunlaşmamıştır. Türk ceza hukuku öğretisinde, bağlılık kuralının nitelikli hâllerin suç ortaklarına geçişi konusunda yeterliliği hakkında iki görüş bulunmaktadır. Birinci gruptaki yazarlara göre, bağlılık kuralının uygulanması, nitelikli hâllerin suç ortaklarına geçişi konusunda bir soruna sebep olmamaktadır. Diğer gruptaki yazarlar ise bağlılık kuralının Kanun’da düzenlen mevcut şeklinin, iştirak hâlinde işlenen suçlarda nitelikli hâllerin şeriklere geçişi konusunda adaletli bir sonuç doğurmadığını savunmaktadır. İkinci gruptaki yazarlar, nitelikli hâllerin şeriklere geçişi konusunda bir kanun boşluğu bulunduğunu ifade ederek bir an önce bir düzenleme yapılması gerektiğini ifade etmektedir. Bu çalışmanın konusu, öğretideki bahsi geçen tartışmaya yöneliktir. Bu bağlamda genel bilgilere yer verildikten sonra konuyla ilgili olarak iki gruba ayrılan yazarların görüşleri karşılaştırmalı olarak incelenerek tartışmaya esas olan konunun daha belirgin hâle getirilmesi amaçlanmıştır.
Halkı Yanıltıcı Bilgiyi Alenen Yayma (Dezenformasyon) Suçu (TCK m. 217/A)
Authors: Sarsıkoğlu Şenel
Published: January 2025

7418 sayılı “Basın Kanunu ile Bazı Kanunlarda Değişiklik Yapılmasına Dair Kanun” 29’uncu maddesiyle Türk Ceza Kanunu (TCK) 217’nci maddesinin ardından gelmek üzere “halkı yanıltıcı bilgiyi alenen yayma” başlığıyla yeni bir hüküm eklenmiş ve kamu barışına karşı suçlar bölümünde bağımsız bir suç tipi öngörülmüştür. 217/A maddesi hükümlerinin uygulanabilmesi için ülkenin iç ve dış güvenliği, kamu düzeni ve genel sağlığı ile ilgili gerçeğe aykırı bir bilginin kamu barışını bozmaya elverişli şekilde alenen yayılması lazım gelmektedir. Ayrıca fail tarafından “sırf halk arasında endişe, korku veya panik yaratmak saikiyle” hareket edilmesi gerekmektedir. Fakat düzenleme, suç hükmünün uygulanışına ilişkin ayrıntı içermemektedir. Bu nedenle, suç hükmünün nasıl uygulanacağı konusu yargı içtihatlarıyla şekillenecektir. Neyin düşünceyi açıklama ve yayma özgürlüğü kapsamında olduğu, neyin dezenformasyon suçu sayılacağı da bu süreçte netleşecektir. Bu durum, ceza hukuku bilimi açısından birçok tartışmaya yol açacaktır. Anayasa Mahkemesi (AYM) de bu maddenin iptali istemiyle yapılan başvurunun oyçokluğu ile reddine karar vererek TCK 217’nci maddesinde yer alan hükmün anayasaya aykırı olmadığına karar vermiştir. Bu içtihat ve karşı oy yazıları suç tipinin anlaşılması bakımından önemi haizdir. Çalışmada ilkin suç tipi, korunan hukuki değer ve insan hakları boyutuyla ele alınmış; sonrasında suç genel teorisi açısından suç tipinin unsurları üzerinde durulmuş; neticede yapılan bu düzenlemenin hukuk devleti ilkesi bakımından yaratabileceği muhtemel problemler yargısal içtihatlardan da yararlanılarak değerlendirilmiştir.
Mobile Apps in Digital Health: Patient Expectations and Factors Influencing Patient Acceptance – a Literature Review
Authors: Radtke Uwe , Wohllebe Atilla
Published: January 2025

With the digitalization of healthcare, mobile apps are also becoming increasingly relevant. This narrative literature review examines the general expectations and requirements of patients for mobile health apps based on scientific studies from the last 10 years (2014-2024), identifies specific functions and features and summarizes the acceptance factors. The results show that mobile health apps should primarily serve the success of treatment. Specifically desired functions include data entry and automated tracking, reminder and alerting, personalization and customization, education and information as well as data sharing and connectivity. Perceived usefulness and ease of use are among the most important acceptance factors. Personal support from healthcare professionals also plays an important role in some contexts. Various further research directions are discussed. Future research could for example focus on the question of how specific functions affect user satisfaction and user loyalty once they have been implemented.
Miniaturized Inset-Fed Microstrip Patch Sensor Based on Meander-Line Slot for Water Measurement Applications
Authors: Aya Khalid Hadi  , Mahmood Farhan Mosleh  , Raed A. Abd-Alhameed
Published: January 2025

This article introduces a high-sensitive microstrip-patch sensor-based meander-line slot structure for water measurement applications. The HFSS software tool is employed to design and simulate the proposed system. The inset-fed sensor size is 60×50×1 mm3 and is printed on a low-cost FR-4 dielectric substrate. The meander-line slots resonator is used in the proposed design to produce strong and concentrated electric fields while increasing the energy output by focusing the current in a narrow area. In addition to enhancing sensitivity, it decreases the sensor dimension, provides a region with strong electric fields, and increases the interaction area with the water. This sample needs to be tested. For the unloaded condition, the miniaturized sensor is resonant at 2.863 GHz with a reflection coefficient (S11) amplitude equal to -30.219 dB. At the same time, the miniaturized sensor is deep at 2.144 GHz, 2.148 GHz, and 3.14 GHz for DI-water, freshwater, and seawater-loaded conditions. According to simulated results, high sensitivity values are found. The sensor has sensitivities of 3.14 and 1.21 for DI water and seawater, respectively. The high sensitivity values of the proposed sensor indicate that any slight change in the εr around the sensing area of the proposed sensor will be translated into significant changes in the resonant frequency and the recorded output results.
Comparatismo intermedial y posthumanismo: transmedialización del mito del cíborg
Authors: Martínez Domingo Sánchez-Mesa , Sánchez Nieves Rosendo
Published: January 2025

En este trabajo se explora la pertinencia de la figura y modelo de identidad del cíborg para el Comparatismo Intermedial. Se ofrece un panorama de problemas asociados susceptibles de análisis, junto a un corpus transmedial de textos culturales relacionados con la ciencia ficción y el cyberpunk seleccionados por su relevancia canónica en cada medio considerado. La Literatura Comparada siempre ha sido una disciplina de fronteras, abordando fenómenos literarios que trascienden las literaturas y lenguas nacionales, basándose en la movilidad de temas, textos, géneros, formas y autores. Posteriormente, ha atendido a las intersecciones de lo literario con otros discursos culturales, especialmente las artes visuales. En la transición del siglo XX al XXI, ya en la denominada cultura postdigital, se ha consolidado el Comparatismo Intermedial, una versión de la Literatura Comparada que desplaza la centralidad de las categorías de lengua y texto hacia la de medio, considerando la intermedialidad, la remediación y la transmedialidad como conceptos y prácticas culturales centrales. En 2024, primer año post explosión de la IA generativa en el sistema de medios y la cultura postdigital global, se reactiva el potencial de un mito que se convierte en categoría teórica central para estudiar las relaciones entre cultura (literatura) y tecnología: el cíborg, un ser en la frontera entre lo orgánico y lo artificial.
Análise da implementação do Programa do Ensino de Química Orgânica no curso de Agro-pecuária no Ensino Técnico Profissional. Estudo de caso Instituto Politécnico de Nhamatanda (ADPP Lamego)
Authors: Tomocene João Gonçalo , Artur Artur Domingos , Pagara Tito Joaquim , Naene Jaime Ernesto , Alface Carlos José Domingos
Published: January 2025

The research aims to analyze the organic chemistry teaching program in the institute’s aforementioned course. Whether they meet the minimum requirements of a teaching program and whether they are suitable for the course or not, given that it aims to train professional technicians at a secondary level. For its materialization, the author used the following methodological procedures: Bibliographical research, where the author read and analyzed books, scientific monographs, articles linked to the topic under study. Direct observation, this technique consisted of analyzing the teaching program for the subject of organic chemistry specifically in the following aspects: objectives, contents, its connection with other subjects, sequence, available teaching time, methodological guidance, experimental activities. Interview which consisted of interviewing the coordinator of the course that covers the discipline of organic chemistry with the aim of understanding whether he has the program, recruitment method and trainer profile to teach this discipline. After analysis and data collection, the results showed that most of the aspects observed are not clear, such as Contents, Logical Sequence, Assessment, Bibliography, despite the high level of existence of the aforementioned aspects, allowing us to conclude that the teaching program of Organic Chemistry in said institution’s course, reasonably meets the minimum requirements required for a chemistry teaching program and is suitable for said course. However, it was recommended that the module of the same program as the aforementioned course be updated and specific, incorporating experimental activities, learning methodologies and teaching resources.
Kompetensi Aparatur dan Budaya Organisasi: Kunci Peningkatan Kinerja di Inspektorat Jenderal Kementerian Pertanian
Authors: Hidayat Rahmat
Published: January 2025

There is a mismatch between expectations and reality in organizational culture that results in low employee and overall organizational performance. An in-depth study is needed to resolve organizational performance issues. This study aims to analyze the impact of apparatus competence and organizational culture on the performance of the Inspectorate General of the Ministry of Agriculture. In a quantitative approach with an associative method, the independent variables are apparatus competence (X1) and organizational culture (X2), while the dependent variable is organizational performance (Y). By understanding the correlation between these aspects, this study is expected to provide strategic contributions to development and management policies at the organizational level.
The Role of The Ratio of Neutrophil Lymphocyte Platelet Lymphocyte and Lymphocyte Monocyte as A Prognostic Factor for Patients with Muscle Invasive Bladder Cancer at Prof Dr. I.G.N.G. Ngoerah Hospital Denpasar
Authors: Rahardjo Simon Ganesya , Yudiana ⁠I Wayan , Mahadewa Tjokorda Gde Bagus
Published: January 2025

Background: Bladder cancer is the type of malignancy most frequently reported in the field of urology, where muscle-invasive bladder cancer (MIBC) accounts for around 25-30% of all cases with this malignancy. Bladder cancer morbidity and mortality are reported to be most common in Asia, where developing countries have a higher mortality-to-morbidity ratio. Several studies have shown the utility of simple laboratory inflammatory marker tests such as NLR, PLR, and LMR as predictors of outcomes in cases of other malignancies. Objective: To prove the value of NLR, PLR, and LMR can show the overall survival rate in post-cystectomy muscle-invasive bladder cancer patients. Method: This type of study is a retrospective cohort study to prove the value of NLR, PLR, and LMR as independent predictors in predicting outcomes in patients with MIBC. The sample was selected using consecutive sampling by selecting subjects who met the research criteria in the period January 2015 to December 2021 involving 50 MIBC patients who have undergone curative procedures at Prof. I. G. N. G Ngoerah Hospital Denpasar. Results: The chi-square test showed that there was a significant association between NLR and MIBC mortality (OR=24.8; 95%CI=2.75-223.2; p=0.001) and between PLR and MIBC mortality (OR=10.8; 95%CI=1.93-60.9; p=0.004). There was no relationship between LMR and MIBC mortality (p=0.561). Meanwhile, the results of multivariate analysis using the Cox regression test showed that high NLR was an independent predictor of MIBC mortality after controlling for confounding variables (OR=27.728; 95%CI=1.443-532.756; p=0.028). Conclusion: High NLR and PLR can indicate a poor overall survival rate in MIBC patients, but only NLR was proven to be significant as an independent predictor for the outcome of MIBC patients.
Characteristics of Patients with Malassezia Folliculitis at Dr. Soetomo Hospital Surabaya: Data Analysis for the Period 2020-2022
Authors: Ahmad Jordy Maulana , Setiabudi Rebekah J. , Ervianti Evy
Published: January 2025

Background: Malassezia Folliculitis (MF) is a skin condition caused by the Malassezia fungus, which is part of the normal skin flora. In Indonesia, MF is common due to factors such as skin hygiene, a hot and humid climate, and frequent misdiagnosis as acne. If left untreated, MF can lead to persistent infections, skin damage, and complications. Understanding the characteristics of MF is important for better prevention, treatment, and improving quality of life. Purpose: To describe the profile of patients with Malassezia Folliculitis at the Dermatology and Venereology Outpatient Unit of RSUD Dr. Soetomo Surabaya from 2020 to 2022. Methods: This retrospective descriptive study analyzed secondary data from medical records at the Dermatology and Venereology Outpatient Unit of RSUD Dr. Soetomo Surabaya for 2020-2022. Results: A total of 87 new MF patient visits were recorded, with the highest number in 2020 (50.57%). Most patients were female (50.57%) and in the late adolescent age group (17-25 years) (48.27%). The primary complaint was nodules (85.05%), and papules were the most common clinical sign (96.55%). Ketoconazole was the most commonly prescribed treatment, both systemically (74.71%) and topically (25.28%). Conclusion: Patients with MF at the Dermatology and Venereology Outpatient Unit of RSUD Dr. Soetomo Surabaya were primarily female and in the late adolescent age group. Nodules and pruritus were common symptoms, and ketoconazole was the main treatment, both systemically and topically.
Analysis of APTT Values, Factor VIII Activity, Factor IX Activity, and Clinical Manifestations in Pediatric Hemophilia Patients at RSUD Dr. Soetomo Surabaya
Authors: Ma’ruf Muhammad Sabilal , Notopuro Paulus Budiono , Andarsini Mia Ratwita , Indrasari Yulia Nadar
Published: January 2025

Background: Hemophilia is a blood clotting disorder caused by a deficiency of blood clotting factors, namely FVIII deficiency (Hemophilia A) and FIX deficiency (Hemophilia B). World epidemiological data shows that the prevalence rate of Hemophilia A is 85-90% and Hemophilia B is 10-15%. Objective: To analyze the correlations between Hemophilia factor activity with APTT values and clinical manifestations of pediatric Hemophilia patients at RSUD Dr Soetomo Surabaya. Methods: This study used a retrospective observational design. Subjects were pediatric hemophilia patients who met the inclusion criteria from total sampling data for the period January 2018-December 2022 from patient medical records. Results: It is known that the majority of pediatric Hemophilia patients in the age range of 2-10 years, as many as 50%. Descriptive statistical values were expressed in (mean ± SD), including APTT value (69 ± 25), FVIII activity (4.6 ± 5.9), and FIX activity (12 ± 15). The most clinical manifestation of bleeding was joint bleeding (hemarthrosis). There were 23 patients with Hemophilia A and 3 patients with Hemophilia B. There was no significant relationship between Hemophilia factor activity and APTT values using the Chi-Square Test statistical test. There was also no significant relationship between hemophilia factor activity and manifestations of hemophilia using the Kruskal-Wallis correlation test. Conclusion: The results of this study indicate that there are no correlations between Factor VIII activity and Factor IX activity with APTT values or with clinical manifestations that occur in patients.
Predictive Factors and Mitigation Strategies for Direct Warping in Rib-Cartilage Grafts: A Comprehensive Literature Review
Authors: Lee Matthew Reinhart Bryce , Nata’atmadja Beta Subakti
Published: January 2025

Rhinoplasty stands as one of the most technically demanding procedures in facial plastic surgery, with costal cartilage grafts (CCGs) serving as essential structural components. Despite their widespread use, these grafts frequently encounter the challenge of direct warping—an immediate deformation occurring upon exposure to saline solution during surgery. This comprehensive review examines the multifaceted factors that influence direct warping, analysing both intrinsic variables such as age and genetic predisposition, and extrinsic factors including nutritional status and lifestyle choices. Through systematic analysis of current literature and clinical data, this study reveals significant correlations between regular vitamin supplementation and reduced warping risk, while identifying modifiable risk factors such as smoking and alcohol consumption that increase susceptibility to graft deformation [1].
The Role of Factor Angiogenic (VEGF) in The Development of Preeclampsia: A Literature Review
Authors: Prakuswo Ryan Sedjati , Lukitasari Lina , Wardhana Manggala Pasca
Published: January 2025

Preeclampsia is a multiorgan disorder of pregnancy that affects about 2-8% of all pregnancies and is one of the leading causes of maternal morbidity and mortality. Preeclampsia occurs in 4.6% of the total 39 million pregnancies. The prevalence of preeclampsia varies in different countries, ranging from 0.4% in Vietnam, 0.015% in Finland, to about 2.9% in some parts of Africa. The pathogenesis of preeclampsia begins with the failure of the physiological transformation of the spiral artery, which causes the placenta to secrete antiangiogenic factors into the maternal blood circulation. Angiogenic factors, such as Vascular Endothelial Growth Factor (VEGF), play an important role in the process of blood vessel formation in the placenta. Angiogenic factors play a role in the pathophysiology of preeclampsia, one of which is VEGF. The literature regarding the association of VEGF with preeclampsia is still limited, so this study was conducted.
Profile of Child Burn Patients in the Plastic Surgery Department at a Tertiary Hospital in Surabaya, Indonesia
Authors: Perdanakusuma Adinda Rahmania , Saputro Iswinarno Doso , Murtiastutik Dwi , Handriani Ira
Published: January 2025

Background: Burns are injuries to the skin that involve two main layers, namely the epidermis outside as a thin layer and the dermis inside as a thick layer. Burns can be associated with significant morbidity and mortality because burns are associated with immune reactions and inflammation, metabolic changes, and distributive shock and require a long process in the healing process. It is imperative that burns not only affect the physical health but also the mental health and quality of life of the patient. Objective: To determine the profile of basic data and clinical data of burn patients in children treated at Dr. Soetomo Hospital in 2020-2022. Methods: This study used secondary medical record data with a retrospective method and was presented descriptively. The study sample was taken by total sampling using all patients who met the inclusion criteria. Results: There were 44 child burn patients treated at RSUD Dr. Soetomo who met the inclusion criteria. Child burn patients were dominated by patients aged 0-5 years and males. It was found that the most common cause of burns in children was hot water, the most depth degree was degree IIB, the most location of burns on the upper extremities, the area of burns was 10-20%, the most severity degree was severe, and the majority of patients were treated for the <1 month. Patient outcome was dominated by patients discharged in a cured/improved condition.
The Role of Outdoor Activities in The Development of Malignant Melanoma: A Literature Review
Authors: Riza Almira Nahla Salsabil , Purnomo Seno , Admar Andalusia Mutiara
Published: January 2025

Malignant melanoma (MM) is a highly aggressive skin malignancy primarily linked to ultraviolet radiation (UVR) exposure. Outdoor activities increase the risk of MM due to prolonged UVR exposure, which can suppress the immune system and promote cancer development. This literature review evaluates the correlation between outdoor activities and the development of MM, emphasizing the role of UVR in inducing DNA damage, immunosuppression, and genetic mutations. Factors such as genetic predisposition, skin phenotype, and occupational exposure further amplify susceptibility to MM. Acute and chronic UVR exposures influence melanoma development differently, with intermittent intense exposure posing the greatest risk. Preventive strategies, including the use of broad-spectrum sunscreens with a minimum SPF of 30, protective clothing, and sun-safe practices, are highlighted as essential measures to mitigate MM risk. Early detection methods, such as self-administered questionnaires and routine skin examinations, are discussed to improve diagnostic accuracy and treatment outcomes. This review underscores the necessity of public health awareness and targeted interventions to address the rising incidence of malignant melanoma globally.
РАЗРАБОТКА АЛГОРИТМА ДЛЯ ЧИСЛЕННОГО РЕШЕНИЯ ЗАДАЧИ ОПТИМАЛЬНОГО УПРАВЛЕНИЯ РЕСУРСАМИ В ТРЁХСЕКТОРНОЙ ЭКОНОМИКЕ
Authors:   КазНУ имени аль-Фараби, Алматы, Казахстан, Тусупова Камшат
Published: January 2025

Статья посвящена разработке алгоритма для численного решения задачи оптимального управления ресурсами в трехсекторной модели экономики с использованием программного обеспечения и языка программирования Maple. Разработанный алгоритм использует метод Рунге-Кутты для численного решения системы уравнений Риккати и вычисления оптимальных траекторий состояния системы и управления. Экономические аспекты модели учтены через условия материального, инвестиционного и трудового баланса, основанные на производственной функции Кобба-Дугласа.
Цель исследования — создание инструмента для минимизации экономических издержек и оптимизации распределения ресурсов. Научная значимость работы заключается в возможности моделирования динамики экономической системы и в анализе влияния управленческих решений на развитие секторов экономики. Методология исследования включает численное моделирование и использование программного обеспечения для реализации алгоритма.
Основным результатом является программный комплекс, который предоставляет инструменты для анализа и визуализации динамики трехсекторной экономики и позволяет оценивать влияние управленческих решений. Программная реализация подтверждает практическую применимость подхода и предоставляет гибкий инструмент для моделирования сложных экономических систем, что делает разработанный алгоритм полезным для научных исследований и практического применения в экономике.
Large-scale reservoir modeling of the Vendenheim geothermal site (France)
Authors: Abreu-Torres Javier , Hutka Gergő , Blöcher Guido , Cacace Mauro , Magnenet Vincent , Schmittbuhl Jean
Published: January 2025

Abstract. During the Vendenheim deep geothermal project (Strasbourg Eurometropole, France), large induced seismic events led to the arrest of the project. Two important features of the induced seismicity were unexpected: the large distance to the wells of a cluster of seismic events (4–5 km) and the occurrence of the largest event Mlv3. 9 at the bottom of the wells, six months after shut-in. To better understand the natural hydro-thermal conditions at the Vendenheim site, we develop within the framework of the DT-GEO project (Horizon Europe) a simplified large-scale model (8 km × 8 km × 6 km) of the area. We aim at performing in-silico experimentation to reproduce the natural hydrothermal state of the geothermal reservoir related to the heat flow (conductive/convective) within the model. We first test our methods by solving 2D and 3D benchmarks related to the convective regime in saturated porous media. Our model is based on the MOOSE/GOLEM framework (finite element approach) and integrate the public regional geological model GEORG that includes major lithologies. We present the coarse-grained simulations of the natural fluid circulation.
Spatio-temporal pattern analysis of MOPITT total column CO using varimax rotation and singular spectrum analysis
Authors: McKinnon John Motley , Roychoudhury Chayan , Arellano Jr. Avelino Florentino
Published: January 2025

Abstract. In this paper, we apply varimax empirical orthogonal function (EOF) analysis to MOPITT total column CO retrievals to answer the question of whether or not it is possible to disentangle the dominant CO sources associated with inferred modes of variability at regional to global scales. Additionally, we write this manuscript with the intention to highlight the strengths and weaknesses of EOF analysis, specifically their usage in the field of atmospheric chemistry. We analyzed daily MOPITT Version 8 Level 3 joint (TIR-NIR) products from 2005 to 2018, aggregated every 8 days on a 1° by 1° grid. Our findings show that EOF patterns of MOPITT CO are consistent across various regional subdomains, demonstrating that these spatial patterns are independent of the chosen domain. A comparison of the eigenvalue spectrum reveals that unrotated EOF analysis yields three distinct modes, while varimax rotation reduces these to two. The power spectra of the principal components indicate that the first two unrotated modes are primarily driven by annual and semi-annual cycles, while the third mode reflects seasonal variations occurring over roughly three months. To further isolate these modes, we employed singular spectrum analysis (SSA) at each grid point to generate long-term, seasonal, and residual EOF patterns. The power spectrum analysis of the principal components shows that the long-term EOFs replicate the original two dominant modes, while the seasonal EOFs reveal significant variations over 2 to 3 months, and the residual modes exhibit time scales of 2 months or shorter. By plotting the mean skewness field we show the dataset is non-Gaussian, leading us to conclude each principal component is time-dependent despite being uncorrelated. The periodic decay observed in the temporal auto-correlation function for each time series suggests a classification of wide-sense cyclostationary or wide-sense polycyclostationary behavior. We find the non-stationarity of each time series together with the temporal dependence of modes leads us to conclude that EOF analysis alone cannot fully disentangle individual CO sources. Consequently, we recommend exploring cyclostationary EOF analysis in future studies. These limitations must be carefully considered when interpreting EOF patterns of other composition datasets with similar characteristics.
Spatial error constraints reduce overfitting for potential field geophysical inversion
Authors: Lindsay Mark Douglas , Ogarko Vitaliy , Giraud Jeremie , Khademi Mosayeb
Published: January 2025

Abstract. Geophysical inversion is an important tool for characterising the structure of the Earth. The utility of geophysical inversion has led to widespread adoption by resource explorers, and used to adapt gravity, magnetic, seismic and electrical datasets into petrophysical models that can be used for targeting. However, inherent ambiguity means that an infinite number of petrophysical models exist that can explain the geophysical data, so constraints such as geological models and petrophysical data have been employed to reduce the solution space. The constraints, like the data, are subject to noise and error resulting in uncertainty propagating to the final model. This is because inversion is designed to use the algorithm and constraints to find the ‘best’ solution by optimising the lowest misfit between the data and model. If the data is uncertain, the model fit to that data is likewise uncertain, and misrepresentative. Optimising misfit also means that inversion is subject to overfitting. Overfitting is when the lowest misfit values are attained by fitting the model to data noise. Overfitting inversion can create anomalies in the near-surface that can be mistakenly identified as legitimate targets for exploration rather than possible model artefacts. This contribution describes the use of spatial error constraints calculated from geophysical data to reduce overfitting for geophysical inversion. The spatial error estimate is derived from a geostatistical model calculated using Integrated Nested Laplacian Approximation (INLA). A region in the East Kimberley, northern Western Australia, is subject to gravity inversion using Tomofast-x, an open-source inversion platform. Inversion using different percentiles from the geophysical model explores whether the extrema of gravimetry values should be considered to explore the model space. Examination of inversion using and not using spatial error constraints shows that overfitting reduction can be achieved while using different percentiles as the observed field has lesser benefits.
A Thorough Review of Antimicrobial Agents Used in Food
Authors: ABDULHUSEIN Haider
Published: January 2025

Antibiotics are agents that have the ability to breakdown microorganisms or restrict their proliferation. These compounds are found in many chemical compositions, including intermediate-metabolite chemicals, chemotherapeutic and antibiotic compounds, non-antibiotic agents, antiseptics, preservatives, and disinfectants. Some of these compounds are naturally produced by bacteria, fungus, and plants. Furthermore, immunological products have been studied as agents with the ability to attack germs. Although there are thousands of antibiotics available, less than 1% of them are actually used in clinical settings to treat infectious. This is because certain antibiotics are unable to penetrate host cells or were toxic to the host. Recently, a wide range of antimicrobial ingredients and chemical additives have been employed in food preparation for both humans and animals, with the purpose of preserving the food. Certainly, using of chemical agents in food can have both pros and cons when utilized in small amounts. The problem of antibiotic resistance is a significant barrier in the food industry. In the development countries, breeders use antibiotics as substances that promote growth. As a result, antibiotics can easily be passed on to humans through the food chain, causing the emergence of antibiotic resistance in many microorganisms. This review emphasized the attributes and applications of substances that are created by fermentation, or other natural techniques utilized in the large-scale production of food.
Biological treatment of domestic wastewater by Escherichia coli
Authors: Jassim Zahraa
Published: January 2025

Escherichia coli may be utilized to decrease some of the contaminants in wastewater from the Al Muthanna wastewater treatment plant’s final sedimentation basins, according to the results of the current research. Using chromogenic urinary tract infection (UTI) agar to create dark blue colonies, bacteria were isolated from the intended area and identified. Escherichia coli was used in the experiment, which was carried out in a lab setting, and it was put to contaminated water that had previously been autoclave-sterilized. Following the incubation of sterile contaminated water and bacteria in the incubator under optimal circumstances, various physical and chemical variables were measured to indicate its potential to eliminate certain pollutants. The findings indicated that the pH had a minor tendency toward alkalinity and that the salinity, nitrates, electrical conductivity, and total alkalinity were all low. On the other hand, the bacteria were very effective in lowering phosphate, calcium, magnesium, and overall hardness. After treatment, the readings of ammonia raised. The results demonstrated how well bacteria work to lower copper and zinc levels in treated water. During the course of the treatment, while the bacteria showed no efficacy in lowering iron levels.
Characterizing Thyrotropin Receptor Antibodies and Hormonal Dynamics in Graves’ Disease: A Comparative Analysis of Treated and Untreated Patients
Authors: Shnawa Zahraa
Published: January 2025

Graves’ disease (GD) constitutes a significant proportion, ranging from 60% to 80%, of diagnosed cases of hyperthyroidism, emerging as a prevalent autoimmune disorder primarily affecting women aged between 30 and 50 years. Notably, GD stands as the foremost etiology of hyperthyroidism within populations endowed with adequate iodine levels. This investigation endeavors to quantify Thyrotropin receptor antibodies (TRAb) in cohorts comprising both untreated individuals and those undergoing pharmacotherapy with anti-thyroid agents, while concurrently evaluating hormonal indices encompassing Thyroid Stimulating Hormone (TSH), Free Thyroxine (FT4), and Free Triiodothyronine (FT3) levels. The study adopts a case-control design encompassing a sample size of 70 participants, inclusive of 40 subjects subjected to anti-thyroid medication and 30 untreated counterparts. Measurement of TRAb levels was facilitated through the utilization of commercially available Enzyme-Linked Immunosorbent Assays (ELISA, whereas assessment of T4, T3, and TSH) levels was executed via immunoenzymatic assays. Before starting carbimazole (CMZ) therapy, people with GD showed significant symptoms.elevated concentrations of FT4, FT3, and TRAb, juxtaposed with diminished TSH levels relative to both treated individuals and healthy controls, achieving statistical significance at p 0.001. Furthermore, a predominance of female participants was observed across all study groups, constituting proportions ranging from 70% to 83.3%. Among the various age strata under scrutiny, the cohort aged over 44 years exhibited the highest mean percentage, with negligible disparity discernible between the second (25-34 years) 11 third (35-44 years) age brackets. The results of this study highlight the unique hormonal profiles observed in patients with GD, characterized by increased levels of FT4, FT3, and TRAb, along with lower TSH levels. The study also shows that GD is more common in females and becomes more prevalent with advancing age.
Projetos de vida de estudantes aprovados e reprovados em uma escola pública
Authors: Pacheco Marcos Da Silva , Rosa Edinete Maria , Pacheco Paula Mello
Published: January 2025

disciplina e conhecimento acadêmico, especialmente na adolescência quando os projetos de vida começam a ganhar mais consistência. Nesse estudo foi analisado de que forma a reprovação escolar impactou o estabelecimento de projetos de vida de adolescentes considerando a Teoria Bioecológica do Desenvolvimento Humano como forma de análise dos dados. Os maiores impactos relatados foram o atraso e a maior dificuldade para a realização dos projetos de vida. Mesmo vivenciando o atraso causado pela reprovação, os alunos ainda relataram planos de ingressar no Ensino Superior, seguir carreira militar ou se inserir imediatamente no mercado de trabalho, mostrando a constância de características biopsicossociais mesmo frente a um evento disruptivo como a reprovação escolar. Os alunos aprovados também mostraram interesse em ingressar na universidade, entretanto, suas escolhas eram menos ambiciosas uma vez que buscavam cursos menos concorridos.
Sheikh Athiyah Saqr's Ijtihad Method on the Obligation of Husband to Fulfill Wife's Wishes When Craving
Authors: Aini Nur , Azwar Zainal
Published: January 2025

Support in a marital relationship is an obligation for a husband towards his wife and children. Fulfilling the wife's wishes when she has cravings is categorized as a husband's maintenance according to Sheikh Athiyah Saqr, which is also legally obligatory. However, seeing the phenomenon of excessive coveting from wives that often occurs nowadays, it is necessary to classify wives' desires, which the husband must fulfill by law. This research aims to analyze Sheikh Athiyah Saqr's method of ijtihad in his fatwa on the obligation for husbands to fulfill their wives' desires when they desire them and to relate the relevance to current phenomena. This research uses the library research method. The data collection technique used is library research. The data analysis technique used in this research is the descriptive method. The result of this research is that Sheikh Athiyar Saqr in determining this fatwa used the qiyas and maslahah murlah methods. According to Sheikh Athiyah Saqr, the obligation of a husband to fulfill his wife's wishes when she desires is translated into the obligation of the husband to provide his wife with daily living. Apart from that, fulfilling the wife's wishes by the husband is considered to bring benefits to the wife and the fetus. However, it is necessary to limit the wife's wishes which must be fulfilled by the husband, namely wishes that do not violate the Shari'a, do not bring harm, and are still within the limits of the husband's capabilities.
Efektifitas Pelaksanaan Undang-Undang Republik Indonesia Nomor 41 Tahun 2004 Tentang Wakaf ditinjau dari Nilai Produktivitas
Authors: Alimudin Alimudin , Ritonga Ahmad Husein , Harun Hermanto
Published: January 2025

Penelitian ini beertujuan untuk mengetahui efektifitas pelaksanaan Undang-Undang Republik Indonesia Nomor 41 Tahun 2004 tentang Wakaf ditinjau dari nilai produktifitas. Penelitian ini menggunakan pendekatan kualitatif, pengumpulan data melalui wawancara, observasi, dan dokumentasi. Berdasarkan hasil penelitian Penggunaan tanah wakaf yang ada di Kabupaten Tanjung Jabung Timur sudah sesuai dengan Undang-Undang Nomor 41 Tahun 2004 Tentang Wakaf, dari jumlah tanah wakaf yang ada berjumlah 433 digunakan dengan rincian: tempat ibadah sebanyak 144 tanah wakaf, makam/kuburan sebanyak 42 tanah wakaf, lembaga pendidikan sebanyak 7 tanah wakaf, dan sosial lainnya sebanyak 240 tanah wakaf. Pengelolaan pengembangan wakaf di Tanjung Jabung Timur masih sangat sederhana, sebagaian besar tidak ada pengembangan pengelolahan secara produktif ekonomis, jika tanah wakaf digunakan untuk pembangunan masjid hanya digunakan untuk pembangunan masjid saja walaupun tanah sisa dari lokasi pembangunan masjid sangat luas tidak dikelola secara produktif, dibiarkan saja semak belukar tanpa manfaat, yang selayaknya tanah wakaf tersebut dapat dikelola secara produktif. Implementasi regulasi wakaf di Kabupaten Tanjung Jabung Timur belum efektif, karena masih terjadi ketidaksesuaian antara das sollen dan das sein, regulasi wakaf yang terdiri dari Undang-Undang Nomor 41 Tahun 3004 tentang wakaf, dan Peraturan Pemerintah Nomor 25 Tahun 2018 tentang perubahan atas perubahan atas Peraturan Pemerintah Nomor 42 Tahun 2006 belum dilaksanakan secara efektif.
Implementation of integrated temperature, humidity, and dust monitoring system on building electrical panel
Authors: Khumaidi Agus , Hasin Muhammad Khoirul , Pujiputra Anggarjuna Puncak , Irsyad Sholahuddin Muhammad , Rinanto Noorman , Rachman Isa , Budi Perdinan Setia , Malik Alfianto Taufiqul , Bayu Nurissabiqoh Binta
Published: January 2025

This research aims to develop and implement an electrical power monitoring system at the Sub Sub Distribution Panel (SSDP) in the Building. The system is designed to monitor power usage in real-time, provide accurate information on energy consumption, and detect potential energy waste. The methodology used includes hardware and software design. The hardware consists of current and voltage sensors connected to a microcontroller. The data collected by the sensors is then transmitted via Wi-Fi network to the server for analysis. The software uses an Internet of Things (IoT) platform that displays the data in the form of graphs and tables. The implementation shows that the system is capable of monitoring power usage with a high degree of accuracy. The sensors used, namely PM2100 for voltage, SHT20 for temperature and humidity, and GP2Y101AU0F for dust concentration, proved effective in generating accurate real-time data. Based on the test results, the voltage measurement error with the PM2100 was only 0.035%, while the current measurement resulted in an error of 0.48%. The SHT20 sensor recorded an error of 2.4% for temperature and 1.0% for humidity. Dust measurements with the GP2Y101AU0F sensor had a very small error of 0.02%. These results indicate that the tested device has a sufficient level of precision for electrical power and environmental monitoring applications.
Development of an IoT-based temperature and humidity prediction system for baby incubators using solar panels
Authors: Mukromin Radian Indra , Setiawan Fachruddin , Pradana Dio Alif , Hyperastuty Agoes Santika , Mukhammad Yanuar
Published: January 2025

Baby incubators are crucial medical devices to maintain environmental stability for babies born prematurely or have health problems. This research aims to develop a prediction system for temperature and humidity variables in baby incubators by utilizing Internet of Things (IoT) technology and solar panels as the main energy source. Despite advancements in IoT-based incubator systems, existing solutions often rely on reactive approaches, making them less effective in preventing harmful environmental fluctuations. Addressing this gap, this study focuses on optimizing temperature and humidity predictions using artificial intelligence (AI) for proactive control. Using a DHT22 sensor to measure temperature and humidity, as well as a 1 Wp solar panel, the system is designed to operate autonomously in areas with limited access to electricity. The methods used include data collection, data processing to calculate correlation coefficients, and selection of linear regression models for the analysis of relationships between variables. The results showed that the linear regression model applied had a good temperature and humidity prediction with a Mean Squared Error (MSE) value of 0.45 for the training data and 7.32 for the test data.