bluuebunny/crossref_metadata_2025 huggingface dataset:
We are all (not) Anonymous: Individual- and country-level correlates of support for and opposition to hacktivism
Authors: Ireland Leanna
Published: September 2022

Hacktivists oftentimes challenge or subvert existing power relations or structures and attempt to promote reform. How the public perceives occurrences of hacktivism can influence the direction and impact of operations, including their potential success. Public support can encompass person power, computational ability, resources and solidarity, among other things. This study examines socio-legal contexts in which an individual is embedded and personal perceptions as predictors for support for hacktivism. Using representative survey data from 23 countries ( n = 23,140), the study finds that more effective civic participation mechanisms and more positive views toward alternative actors and hacktivists’ utilitarianism motives were associated with heightened support. In contrast, greater trust in legal and state authorities promoted opposition. Effective justice was not associated with more support but was with less opposition for hacktivism. Implications for campaigns, social movements, and desistance of activity are discussed.
Investigation on micro-textured tappets from design and production to the application properties
Authors: Reck M , Orgeldinger C , Tremmel S , Merklein M
Published: September 2022

In industrial sectors like medical and automotive engineering, the demand for metal components with a high function integration brings conventional production technologies to their limits. This motivates research on innovative processes, which can meet the present requirements on fabricated parts and consequently also the demands on the applied manufacturing process. Part-sided, a high strength, narrow dimensional tolerances and a large functionality is often desired. In addition, an economical component production calls for processes with high material utilization as well as the achievement of short cycle times. The process class of sheet-bulk metal forming, characterized by the application of bulk forming operations on sheet metal, offers the potential to meet these requirements. Currently, sheet-bulk metal forming is mainly used for the fabrication of components with functional elements of macroscopic size. However, microscopic elements and micro-textured surfaces are of high interest for applications in prosthetics and automotive engineering. The objective of this study is therefore to develop an application-oriented method for the design, production and testing of 16MnCr5 metal components, manufactured by a combined process of sheet-bulk metal forming, creating a defined microstructure on the surface. Since the selection of a suitable texture layout and geometry is crucial for tribological optimization, these are designed for their application using numerical elastohydrodynamic lubricant simulations. The contact conditions occurring in the application are modelled as realistically as possible so that texture designs suitable for production can subsequently be compared in test bench trials. It is shown that the tappets produced by forming technology can be efficiently investigated with the test rig presented.
Recurrent events analysis with piece-wise exponential additive mixed models
Authors: Ramjith Jordache , Bender Andreas , Roes Kit C. B. , Jonker Marianne A.
Published: September 2022

Recurrent events analysis plays an important role in many applications, including the study of chronic diseases or recurrence of infections. Historically, many models for recurrent events have been variants of the Cox model. In this article we introduce and describe the application of the piece-wise exponential Additive Mixed Model (PAMM) for recurrent events analysis and illustrate how PAMMs can be used to flexibly model the dependencies in recurrent events data. Simulations confirm that PAMMs provide unbiased estimates as well as equivalence to the Cox model when proportional hazards are assumed. Applications to recurrence of staphylococcus aureus and malaria in children illustrate the estimation of seasonality, bivariate non-linear effects, multiple timescales and relaxation of the proportional hazards assumption via time-varying effects. The R package pammtools is extended to facilitate estimation and visualization of PAMMs for recurrent events data.
A Feature Extraction & Selection Benchmark for Structural Health Monitoring
Authors: Buckley Tadhg , Ghosh Bidisha , Pakrashi Vikram
Published: September 2022

There are a large number of time domain, frequency domain and time-frequency signal processing methods available for univariate feature extraction. However, there is no consensus in SHM on which feature, or feature sets, are best suited for the identification, localisation and prognosis of damage. This paper attempts to address this problem by providing a comprehensive benchmark of feature selection & reduction methods applied to an extensive set of univariate features. These univariate features are extracted using multiple statistical, temporal and spectral methods from the benchmark S101 and Z24 bridge datasets. These datasets contain labelled accelerometer recordings from full scale bridges as they are progressively subjected to multiple damage scenarios. To identify the minimal set of features that best distinguishes between the multiple damage states, a supervised machine learning approach is used in combination with multiple feature selection methods. The ability of these reduced feature sets to distinguish between damage states is benchmarked using the prediction performance of the classification models, with the training and test sets obtained through stratified k-fold cross validation. The results obtained show that reduced sets of univariate features, extracted from a single accelerometer sensor, are capable of accurately distinguishing between multiple classes of healthy and damaged states. This work provides a benchmark for SHM practitioners and researchers alike for the choice, comparison and validation of feature extraction and feature selection methods across a wide range of systems.
Overcoming path-dependent dynamic capabilities
Authors: Keller Arne , Konlechner Stefan , Güttel Wolfgang H , Reischauer Georg
Published: September 2022

While seminal work on dynamic capabilities highlights path-dependent trajectories as an important and distinguishing property, recent studies tend to marginalize this feature in favor of an ahistorical and unbound conceptualization. Following the recent “history turn” in strategy and organization research, we examine the essential yet inadequately understood role of path dependence in dynamic capability building and adaptation. Precisely, we demonstrate that dynamic capabilities, as pattern-based, learned, and context-specific entities, are prone to become path-dependent under the effect of self-reinforcing mechanisms. We further show that in the face of discontinuous environmental shifts, path-dependent dynamic capabilities can—paradoxically enough—turn dysfunctional as they perpetuate current, potentially outdated ways through which a firm reconfigures its resource base. Based on this analysis, we identify ad hoc managerial action as the basis for path transformation and path dissolution, as well as path switching and new path creation, which represent complementary ways to deal with path-dependent dynamic capabilities. Our theorizing extends a contingency perspective on dynamic capabilities by shedding light on the limits and potential alternatives of pattern-based adaptation.
Digital transformation in higher education from online learning perspective: A comparative study of Singapore and Vietnam
Authors: Nguyen-Anh Tuan , Nguyen Anh T , Tran-Phuong Chi , Nguyen-Thi-Phuong Anh
Published: September 2022

Digital transformation has been inevitable in all socio-economic fields, including higher education. Recently, under the burden of the COVID-19 pandemic, many universities have to change their entire teaching systems to online learning to ensure their students' learning is not interrupted. Thus, it is essential to study how universities’ students, educators, and administrators perceive online learning in different countries. To this aim, this study investigates the factors affecting university members' preference for online learning in Singapore and Vietnam. Using a cross-country sample with a sound theoretical framework of the Technology Acceptance Model (TAM), we found that each member group in the university was influenced by a different weight of factors. Specifically, students' preference for online learning is most affected by their technical skills. Meanwhile, educators and administrators are influenced mainly by the perceived usefulness of online learning and practice conditions, respectively. We further conducted multi-group testing and confirmed the certain separation in online learning preferences of observed objects between the two countries. Overall, this paper enriches the literature on online education, and has important implications for educational policymakers and university stakeholders both during and after the pandemic.
An Oscillatory Shear Index-Based Model to Describe Progressive Carotid Artery Stenosis
Authors: Patalano Peter
Published: September 2022

Background and aims: This study describes and demonstrates the applicability of a novel in silico method for modeling progressive carotid artery stenosis using the oscillatory shear index (OSI) as the basis of stenosis. Methods: Three-dimensional reconstructions of 11 carotid arteries were generated using patient-derived magnetic resonance angiography and duplex ultrasound data. Computational fluid dynamic simulations were sequentially generated following computational stenosis assessment, and corresponding changes in OSI were observed and used as measure of morphological stabilization. Results: 6 carotid models showed progressive stenosis with statistically significant increases in regions of high OSI (OSI >.2, P < .05) with eventual carotid occlusion in 1 of the cases. Three models remained free or nearly free of increased OSI, whereas 1 model showed an overall decrease in high OSI regions (P < .05) and another trended in that direction but did not achieve statistical significance ( P = .145). Conclusions: To our knowledge, this is the first computational model describing progressive stenosis in any peripheral artery including the carotid. Taken together, this study provides a novel framework for computational hemodynamic investigations on progressive atherosclerosis in the carotid artery.
Assessing the Quality of Vascular Ultrasound Examinations Using the IAC QI Self-Assessment Tool: Inter-Rater and Intra-Rater Agreement Between Vascular Technologists and Interpreting Physicians
Authors: Bajwa Bakhtawar N. , Esterson Yonah B. , Naidich James B. , Burke Brian J. , D’Agostino Catherine A. , Kline Myriam , Pellerito John S.
Published: September 2022

Introduction:

Vascular laboratories need to improve efficiency while maintaining examination quality. Vascular ultrasound examinations were retrospectively evaluated using the Intersocietal Accreditation Commission (IAC) Quality Improvement (QI) Self-Assessment Tool to evaluate the quality of the examinations and to determine inter-rater and intra-rater agreement between groups of vascular technologists and interpreting physicians.

Methods:

Vascular technologists and attending interpreting physicians evaluated 100 carotid Doppler and 100 lower extremity venous Doppler examinations utilizing the IAC QI Self-Assessment Tool. Gwet’s First-Order Agreement Coefficient (AC1) statistic and 95% confidence intervals were calculated to determine both inter-rater and intra-rater agreement.

Results:

The inter-rater agreement for 91% of all questions ranged from substantial (AC1 = 0.6) to almost perfect (AC1 = 1) for both examination types across all reviewers. Agreement on 2 questions was suboptimal: specifically, the technical quality section for the vascular technologists showed slight agreement for carotid Doppler and venous Doppler examinations (AC1 = 0.108 and 0.087, respectively), and the case review section for the interpreting physicians showed poor agreement for carotid Doppler examinations (AC1 = –0.087) and fair agreement for venous Doppler examinations (AC1 = 0.329). The intra-rater agreement among the interpreting physicians for both examinations was in the almost perfect range (Carotid AC1 = 0.875-1; Venous AC1 = 0.871-1). The intra-rater agreement among the vascular technologists for both examinations ranged from slight to almost perfect (Carotid AC1 = 0.191-1; Venous AC1 = 0.155-1).

Conclusion:

Substantial to almost perfect agreement among all reviewers was observed for most of the quality review questions. The IAC QI Self-Assessment Tool aided in identifying areas for improvement in vascular studies and the comments captured in the technical quality section of the tool were instrumental in establishing areas for quality improvement.
Review of artificial intelligence-based bridge damage detection
Authors: Zhang Yang , Yuen Ka-Veng
Published: September 2022

Bridges are often located in harsh environments and are thus extremely susceptible to damage. If the initial damage is not detected in time, it can develop further causing safety hazards. Therefore, accurate detection of bridge damage is an important topic. In recent years, artificial intelligence technology has been developed rapidly, especially machine learning algorithms, which have shown amazing results in various fields while it also received attention in bridge inspection. This paper summarizes the progress of bridge damage detection research related to artificial intelligence techniques between 2015 and 2021. For structural health monitoring, sensing data is the basis for various data processing methods. The strength and weakness of the sensing data itself directly affect the effectiveness of subsequent processing methods. As a result, this paper classifies bridge damage detection studies into six categories from the types of sensing data: visual image, point cloud, infrared thermal imaging, ground-penetrating radar, vibration response, and other types of data. These six types of damage detection methods were reviewed and summarized respectively. Finally, challenges and future trends were discussed.
How Do We Learn Now? Pluralising Urban Pedagogies in the COVID-19 Pandemic
Authors: Wesely Julia , Lall Ruchika , Dutta Nandini , Anand Geetika , Allen Adriana
Published: September 2022

Since 2020, pedagogues and learners in the field of urban planning and practice have rapidly responded to new demands and realities posed by the COVID-19 pandemic. These have included shifting the modes and sites of learning from classrooms to screens, developing new programmes to build urgently required local capacities, fostering partnerships and platforms that sustain remote ways of learning together, and facilitating multi-sensorial and inclusive learning practices. This plurality of pedagogic adaptation and innovation suggests complex and nuanced relations with urban (in)equality, going beyond the dominant narrative of the digital divide and distributive inequalities in higher education. This article reflects on three experiences of critical pedagogies undertaken by researchers and activists, social movements and organised civil society from India, Brazil and Argentina. As the impacts of the pandemic on the nexus between urban practice and pedagogy unfold, we argue that these reflexions-in-action on decisions made, along with their underlying principles, are important stimuli for pluralising questions of what, where, with whom and how we learn to respond to urban inequalities. Moreover, they open nuanced discussions to strategically reimagine future hybrid learning trajectories to support pathways to urban equality.
End-stage crystalline maculopathy with retinal atrophy in Sjögren-Larsson syndrome: a case report and review of the literature
Authors: Lambert Lester H. , Shaikh Noreen , Marx Jeffrey L. , Ramsey David J.
Published: September 2022

Sjögren-Larsson syndrome (SLS) is a rare, autosomal recessive neurocutaneous disorder. It is caused by the inheritance of sequence variants in the ALDH3A2 gene, which codes for fatty aldehyde dehydrogenase (FALDH). Universal signs of the condition are congenital ichthyosis, spastic paresis of the lower and upper limbs, and reduced intellectual ability. In addition to this clinical triad, patients with SLS experience dry eyes and decreased visual acuity caused by a progressive retinal degeneration. Examination of the retina in patients with SLS often reveals glistening yellow crystal-like deposits surrounding the fovea. This crystalline retinopathy often develops in childhood and is considered pathognomonic for the disease. The metabolic disorder typically shortens lifespan to half that of the unaffected population. However, now that patients with SLS live longer, it becomes increasingly important to understand the natural course of the disease. Our case describes a 58-year-old woman with advanced SLS whose ophthalmic examination illustrates the end-stage of the retinal degeneration. Optical coherence tomography (OCT) and fluorescein angiography confirm the disease is restricted to the neural retina with dramatic thinning of the macula. This case is unique since it is among the most advanced both in terms of chronological age and severity of retinal disease. While the accumulation of fatty aldehydes, alcohols, and other precursor molecules is the probable cause of retinal toxicity, a more complete understanding of the course of retinal degeneration may aid in the development of future treatments. The aim of our presentation of this case is to increase awareness of the disease and to foster interest in therapeutic research which may benefit patients with this rare condition.
Self-organization in online collaborative work settings
Authors: Lykourentzou Ioanna , Vinella Federica Lucia , Ahmed Faez , Papastathis Costas , Papangelis Konstantinos , Khan Vassilis-Javed , Masthoff Judith
Published: September 2022

As the volume and complexity of distributed online work increases, collaboration among people who have never worked together in the past is becoming increasingly necessary. Recent research has proposed algorithms to maximize the performance of online collaborations by grouping workers in a top-down fashion and according to a set of predefined decision criteria. This approach often means that workers have little say in the collaboration formation process. Depriving users of control over whom they will work with can stifle creativity and initiative-taking, increase psychological discomfort, and, overall, result in less-than-optimal collaboration results—especially when the task concerned is open-ended, creative, and complex. In this work, we propose an alternative model, called Self-Organizing Pairs (SOPs), which relies on the crowd of online workers themselves to organize into effective work dyads. Supported but not guided by an algorithm, SOPs are a new human-centered computational structure, which enables participants to control, correct, and guide the output of their collaboration as a collective. Experimental results, comparing SOPs to two benchmarks that do not allow user agency, and on an iterative task of fictional story writing, reveal that participants in the SOPs condition produce creative outcomes of higher quality, and report higher satisfaction with their collaboration. Finally, we find that similarly to machine learning-based self-organization, human SOPs exhibit emergent collective properties, including the presence of an objective function and the tendency to form more distinct clusters of compatible collaborators.
Clinical response to belumosudil in bronchiolitis obliterans syndrome: a combined analysis from 2 prospective trials
Authors: DeFilipp Zachariah , Kim Haesook T. , Yang Zhongming , Noonan John , Blazar Bruce R. , Lee Stephanie J. , Pavletic Steven Z. , Cutler Corey
Published: September 2022

Chronic graft-versus-host disease (cGVHD) of the lung, or bronchiolitis obliterans syndrome (BOS), is a high-risk disease manifestation associated with poor outcomes. Currently available treatments have demonstrated limited clinical efficacy in this setting. Belumosudil is a novel oral selective rho-associated coiled-coil–containing protein kinase-2 inhibitor that was recently approved by the US Food and Drug Administration in the treatment of cGVHD. We identified 59 subjects with BOS who were enrolled and treated in 2 prospective clinical trials of belumosudil. Patients with BOS had a percentage predicted forced expiratory volume in 1 second (FEV1) of ≤79% at enrollment and clinician attribution of lung disease owing to cGVHD. The National Institutes of Health (NIH) cGVHD lung scores at enrollment were 1 (n = 30, 59%), 2 (n = 23, 39%), or 3 (n = 6, 10%). According to NIH response criteria, the best overall response rate (ORR) for lung cGVHD was 32% (partial response: 17%; complete response: 15%). Response rates were inversely proportional to baseline NIH GVHD lung score at enrollment (lung score 1: ORR 50%; lung score 2: ORR 17%, lung score 3: ORR 0%) (P = .006). In multivariable analysis, male sex, lower baseline NIH cGVHD lung score, and partial response to previous line of cGVHD therapy before enrollment were associated with higher rates of lung-specific response. No significant correlation was identified between pulmonary function evaluations and measures of patient symptoms (NIH lung symptom score or Lee Symptom Scale score for lung). In conclusion, belumosudil treatment was associated with lung-specific clinical responses for subjects with BOS, which were more commonly observed in less advanced disease. Optimization of treatment response evaluations remains a challenge in patients with BOS.
Sequential pembrolizumab and AVD are highly effective at any PD-L1 expression level in untreated Hodgkin lymphoma
Authors: Allen Pamela B. , Lu Xinyan , Chen Qing , O’Shea Kaitlyn , Chmiel Joan S. , Slonim Liron Barnea , Sukhanova Madina , Savas Hatice , Evens Andrew M. , Advani Ranjana , Pro Barbara , Karmali Reem , Palmer Brett , Bayer Robert A. , Eisner Robert M. , Mou Eric , Dillehay Gary , Gordon Leo I. , Winter Jane N.
Published: September 2022

In a multicenter, phase 2, investigator-initiated trial of sequential pembrolizumab and AVD (doxorubicin, vinblastine, and dacarbazine), nearly two-thirds of patients with untreated, unfavorable, or advanced-stage classic Hodgkin lymphoma (cHL) achieved positron emission tomography (PET)–defined, complete or near-complete metabolic responses (CMRs), following pembrolizumab monotherapy. Furthermore, all patients achieved CMR after 2 cycles of AVD, with 100% of patients alive and without relapse at initial publication. We now report long-term follow-up, including the 3-year overall survival (OS) and planned correlative analyses. Thirty patients received 3 cycles of single-agent pembrolizumab, followed by AVD chemotherapy for 4 to 6 cycles depending on the stage and bulk. PET/computed tomography scan was performed after pembrolizumab monotherapy, 2 cycles of AVD, and at the end of therapy. Baseline biopsy samples were analyzed for genomic alterations of chromosome 9p24.1 and programmed cell death protein 1 (PD-1) pathway markers. At a median follow-up of 33.1 months (range, 26.0-43.0), progression-free survival and OS remained 100%. All patients had genomic alterations in 9p24.1 and were positive for programmed death ligand 1 (PD-L1) by immunohistochemistry. There was no relationship between depth of response to single-agent pembrolizumab and 9p24.1 alterations or PD-1 pathway H-scores. After additional follow-up, sequential pembrolizumab and AVD remained highly effective. The high response rates observed at all PD-L1 levels suggest that even low levels of PD-L1 expression are sufficient for response to PD-1 blockade in untreated cHL. An international phase 2 trial (registered at www.clinicaltrials.gov as #NCT03226249) is ongoing to confirm our findings.
Obesity, hypertension, and tobacco use associated with left ventricular remodeling and hypertrophy in South African women: Birth to Twenty Plus Cohort
Authors: Kolkenbeck-Ruh Andrea , Soepnel Larske M. , Crouch Simone H. , Naidoo Sanushka , Smith Wayne , Norris Shane A. , Davies Justine , Ware Lisa J.
Published: September 2022

Background

Left ventricular hypertrophy (LVH) is a marker of increased risk in developing future life-threatening cardiovascular disease (CVD), however, it is unclear how CVD risk factors, such as obesity, blood pressure (BP), and tobacco use, are associated with left ventricular (LV) remodeling and LVH in urban African populations. Therefore, we aimed to identify the prevalence of LVH as well as the health factors associated with LV remodeling and LVH, within black South African adult women and their pre-pubescent children.

Methods

Black female adults (n = 123; age: 29–68 years) and their children (n = 64; age: 4–10; 55% female) were recruited from the Birth to Twenty Plus Cohort in Soweto, South Africa. Tobacco and alcohol use, physical activity, presence of diabetes mellitus, heart disease, and medication were self-reported. Height, weight, and blood pressure were measured in triplicate to determine the prevalence of obesity and hypertension respectively. Echocardiography was used to assess LV mass at end-diastole, based on linear measurements, and indexed to body surface area to determine LVH.

Results

Hypertension and obesity prevalences were 35.8% and 59.3% for adults and 45.3% and 6.3% for children. Self-reported tobacco use in adults was 22.8%. LVH prevalence was 35.8% in adults (75% eccentric: 25% concentric), and 6.3% in children. Concentric remodeling was observed in 15.4% of adults, however, concentric remodeling was only found in one child. In adults, obesity [OR: 2.54 (1.07–6.02; p = 0.02)] and hypertension [3.39 (1.08–10.62; p = 0.04)] significantly increased the odds of LVH, specifically eccentric LVH, while concentric LVH was associated with self-reported tobacco use [OR: 4.58 (1.18–17.73; p = 0.03)]. Although no logistic regression was run within children, of the four children LVH, three had elevated blood pressure and the child with normal blood pressure was overweight.

Conclusions

The association between obesity, hypertension, tobacco use, and LVH in adults, and the 6% prevalence of LVH in children, calls for stronger public health efforts to control risk factors and monitor children who are at risk.
Conjoint analyses of patients’ preferences for primary care: a systematic review
Authors: Lim Audrey Huili , Ng Sock Wen , Teh Xin Rou , Ong Su Miin , Sivasampu Sheamini , Lim Ka Keat
Published: September 2022

Background

While patients’ preferences in primary care have been examined in numerous conjoint analyses, there has been little systematic effort to synthesise the findings. This review aimed to identify, to organise and to assess the strength of evidence for the attributes and factors associated with preference heterogeneity in conjoint analyses for primary care outpatient visits.

Methods

We searched five bibliographic databases (PubMed, Embase, PsycINFO, Econlit and Scopus) from inception until 15 December 2021, complemented by hand-searching. We included conjoint analyses for primary care outpatient visits. Two reviewers independently screened papers for inclusion and assessed the quality of all included studies using the checklist by ISPOR Task Force for Conjoint Analysis. We categorized the attributes of primary care based on Primary Care Monitoring System framework and factors based on Andersen’s Behavioural Model of Health Services Use. We then assessed the strength of evidence and direction of preference for the attributes of primary care, and factors affecting preference heterogeneity based on study quality and consistency in findings.

Results

Of 35 included studies, most (82.4%) were performed in high-income countries. Each study examined 3–8 attributes, mainly identified through literature reviews (n = 25). Only six examined visits for chronic conditions, with the rest on acute or non-specific / other conditions. Process attributes were more commonly examined than structure or outcome attributes. The three most commonly examined attributes were waiting time for appointment, out-of-pocket costs and ability to choose the providers they see. We identified 24/58 attributes with strong or moderate evidence of association with primary care uptake (e.g., various waiting times, out-of-pocket costs) and 4/43 factors with strong evidence of affecting preference heterogeneity (e.g., age, gender).

Conclusions

We found 35 conjoint analyses examining 58 attributes of primary care and 43 factors that potentially affect the preference of these attributes. The attributes and factors, stratified into evidence levels based on study quality and consistency, can guide the design of research or policies to improve patients’ uptake of primary care. We recommend future conjoint analyses to specify the types of visits and to define their attributes clearly, to facilitate consistent understanding among respondents and the design of interventions targeting them.

Word Count: 346/350 words.

Trial registration

On Open Science Framework:https://osf.io/m7ts9
Double trouble - management of perinephric hematoma and renal vein thrombosis post percutaneous renal biopsy
Authors: Kamarudin Muhammad Imran , Nadarajan Chandran , Daud Mohamed Ashraf Mohamed
Published: September 2022

Background

Performing percutaneous renal biopsy procedures in lupus nephritis (LN) and nephrotic syndrome presents a unique challenge to the nephrologist because of the risk of bleeding from the procedure and the hypercoagulable state in hypoalbuminemia. The management of a patient with venous thrombosis with perinephric hematoma post renal biopsy can be difficult if occurred.

Case presentation

We are presenting a case of perinephric hematoma following percutaneous renal biopsy in a 23-year-old man with lupus nephritis, nephrotic syndrome, and lower limbs deep vein thrombosis (DVT). The patient developed persistent frank haematuria, flank pain and acute urinary retention post-procedure. We have withheld his oral warfarin three days before the procedure, and no anticoagulation was given subsequently. Initial CT Angiography (CTA) renal showing stable hematoma and no visible evidence of vascular injury. Three weeks later, the patient still has persistent frank haematuria and a repeated CTA renal revealed new bilateral renal vein thrombosis. Considering the high risk of worsening symptomatic venous thrombosis, we gave subcutaneous enoxaparin sodium and restart oral warfarin despite ongoing haematuria. The frank haematuria resolved within two days of anticoagulation with no radiological evidence of worsening of the perinephric hematoma. The follow-up ultrasonography a month later showed resolution of the hematoma and renal vein thrombosis with no adverse effect.

Conclusion

Our experience, in this case, highlighted the importance of case selection for percutaneous renal biopsy among high-risk patients. Additionally, a prolonged frank haematuria in post-renal biopsy with nephrotic syndrome warranted a reassessment, as a clinical presentation of post-procedure perinephric hematoma and renal vein thrombosis can overlap. We also demonstrated that restarting anticoagulation earlier than four weeks in a patient with renal vein thrombosis and post-renal biopsy perinephric hematoma can be safe in the selective case.
Dietary total anti-oxidant capacity is inversely related to the prevalence of depression in adolescent girls
Authors: Zohrabi Tayebeh , Ziaee Amirhosein , Salehi-Abargouei Amin , Ferns Gordon A. , Ghayour-Mobarhan Majid , Khayyatzadeh Sayyed Saeid
Published: September 2022

Background

Oxidative stress is considered to be a contributory factor for depression, and is affected by the dietary intake of pro-and anti-oxidants. Dietary total antioxidant capacity (DTAC) is an index which is applied to estimate the cumulative power of antioxidants in the whole diet. The aim of this study was to determine the relationship between DTAC and prevalence of depression in adolescent girls.

Methods

A total of 741 Iranian adolescent girls aged 12–18 years were recruited into this cross-sectional study. Dietary intake and depression severity score were assessed using a food frequency questionnaire and Beck's depression inventory, respectively. To estimate the DTAC, the oxygen radical absorbance capacity method was used for selected foods. To explore the associations between DTAC and depression, logistic regression was applied using crude and adjusted models.

Results

Individuals in the greatest adherence to high DTAC had more intakes of whole grains, legumes, fruits, dried fruits, low fat dairy products, cruciferous vegetables, fiber, magnesium, vitamin C, folate, potassium, zinc, β-carotene, lutein, thiamin, riboflavin, niacin and vitamin B-6 and lower consumption of refined grains. Subjects in the highest quartile of DTAC had a 39% lower odds of depression compared to those in the first quartile (OR = 0.61; 95% CI: 0.38–0.97, P for trend = 0.012); these associations remained significant after adjustments in first, second and third (OR = 0.5; 95% CI: 0.28–0.92, P for trend < 0.001) adjusted models.

Conclusions

An inverse association was observed between the DTAC and the prevalence of depression in our population sample of adolescent girls. Further research needs to be conducted in different areas, including longitudinal studies with larger sample sizes.
Investigation of the role of sleep and physical activity for chronic disease prevalence and incidence in older Irish adults
Authors: Hernández Belinda , Scarlett Siobhán , Moriarty Frank , Romero-Ortuno Roman , Kenny Rose Anne , Reilly Richard
Published: September 2022

Background

Chronic diseases are the leading cause of death worldwide. Many of these diseases have modifiable risk factors, including physical activity and sleep, and may be preventable. This study investigated independent associations of physical activity and sleep with eight common chronic illnesses.

Methods

Data were from waves 1, 3 and 5 of The Irish Longitudinal Study on Ageing (n = 5,680). Inverse probability weighted general estimating equations were used to examine longitudinal lifetime prevalence and cumulative incidence of self-reported conditions.

Results

Sleep problems were significantly associated with increased odds of incident and prevalent arthritis and angina. Additionally sleep problems were associated with higher odds of lifetime prevalence of hypertension and diabetes. Physical activity was negatively associated incident osteoporosis and respiratory diseases and negatively associated with lifetime prevalence of hypertension, high cholesterol and diabetes.

Conclusions

Worse sleep quality and lower physical activity were associated with higher odds of chronic diseases. Interventions to improve sleep and physical activity may improve health outcomes.
Symptomatic unilateral idiopathic giant bullous emphysema : a case report
Authors: Garvey S. , Faul J. , Cormican L. , Eaton D. , Judge E. P.
Published: September 2022

Background

Idiopathic Giant Bullous Emphysema (or Vanishing Lung Syndrome) is a rare condition which is usually associated with male gender, active smoking and underlying emphysematous disease. We present an unusual case of a giant bulla occurring in the absence of these risk factors.

Case presentation

A 54-year-old woman presented to the respiratory outpatient clinic with gradually worsening left sided chest discomfort, which was most marked during a recent flight. She had no significant dyspnoea or other symptoms. She had a remote 5-pack-year smoking history. Chest X-Ray revealed a large hyperlucent area in the left upper lobe. CT Thorax found this to be an isolated bulla occupying more than one-third of the hemithorax. The remaining lung parenchyma was normal. A diagnosis of Idiopathic Giant Bullous Emphysema was made. The patient was referred for VATS (Video-assisted thoracoscopic surgery) bullectomy which was carried out without complication. Her symptoms resolved completely following the operation.

Conclusions

This is an unusual case of a solitary giant bulla occurring without major risk factors or underlying lung disease. VATS bullectomy was shown to be an effective therapeutic option, allowing re-expansion of compressed lung tissue and complete resolution of symptoms.
Intracorporeal reinforcement with barbed suture is associated with low anastomotic leakage rates after laparoscopic low anterior resection for rectal cancer: a retrospective study
Authors: Lin Haiping , Yu Minhao , Ye Guangyao , Qin Shaolan , Fang Hongsheng , Jing Ran , Gong Tingyue , Luo Yang , Zhong Ming
Published: September 2022

Background

Anastomotic leakage (AL) is one of most severe postoperative complications following low anterior resection (LAR) for rectal cancer, and has an adverse impact on postoperative recovery. The occurence of AL is associated with several factors, while few studies explored the role of intracorporeal barbed suture reinforcement in it.

Methods

Consecutive cases underwent laparoscopic LAR for rectal cancer from Mar. 2018 to Feb. 2021 in our center were retrospectively collected. Cases were classified into the intracorporeal barbed suture reinforcement group and the control group according to whether performing intracorporeal reinforcement with barbed suture, and AL incidences were compared between two groups. Propensity score matching (PSM) was then performed based on identified risk factors to reduce biases from covariates between two groups. AL incidences in the matched cohort were compared.

Results

A total of 292 cases entered into the study, and AL incidences were significantly lower in the intracorporeal barbed suture reinforcement group compared with the control group (10.00% vs 2.82%, P = 0.024). Sex, BMI, preoperative adjuvant chemoradiotherapy and anastomotic level were chose for PSM analyses based on previous studies. In the matched cohort, the AL incidences were still significantly lower in the intracorporeal barbed suture reinforcement group (10.57% vs 2.44%, SD = 0.334).

Conclusions

Intracorporeal barbed suture reinforcement is associated with low AL incidences after laparoscopic LAR for rectal cancer, which is a potential procedure for reducing AL and worthy of application clinically.
Associations between grip strength, brain structure, and mental health in > 40,000 participants from the UK Biobank
Authors: Jiang Rongtao , Westwater Margaret L. , Noble Stephanie , Rosenblatt Matthew , Dai Wei , Qi Shile , Sui Jing , Calhoun Vince D. , Scheinost Dustin
Published: September 2022

Background

Grip strength is a widely used and well-validated measure of overall health that is increasingly understood to index risk for psychiatric illness and neurodegeneration in older adults. However, existing work has not examined how grip strength relates to a comprehensive set of mental health outcomes, which can detect early signs of cognitive decline. Furthermore, whether brain structure mediates associations between grip strength and cognition remains unknown.

Methods

Based on cross-sectional and longitudinal data from over 40,000 participants in the UK Biobank, this study investigated the behavioral and neural correlates of handgrip strength using a linear mixed effect model and mediation analysis.

Results

In cross-sectional analysis, we found that greater grip strength was associated with better cognitive functioning, higher life satisfaction, greater subjective well-being, and reduced depression and anxiety symptoms while controlling for numerous demographic, anthropometric, and socioeconomic confounders. Further, grip strength of females showed stronger associations with most behavioral outcomes than males. In longitudinal analysis, baseline grip strength was related to cognitive performance at ~9 years follow-up, while the reverse effect was much weaker. Further, baseline neuroticism, health, and financial satisfaction were longitudinally associated with subsequent grip strength. The results revealed widespread associations between stronger grip strength and increased grey matter volume, especially in subcortical regions and temporal cortices. Moreover, grey matter volume of these regions also correlated with better mental health and considerably mediated their relationship with grip strength.

Conclusions

Overall, using the largest population-scale neuroimaging dataset currently available, our findings provide the most well-powered characterization of interplay between grip strength, mental health, and brain structure, which may facilitate the discovery of possible interventions to mitigate cognitive decline during aging.
Perfluoroalkyl substances (PFASs) as risk factors for breast cancer: a case–control study in Chinese population
Authors: Li Xuejun , Song Fengju , Liu Xiaotu , Shan Anqi , Huang Yubei , Yang Zhengjun , Li Haixin , Yang Qiaoyun , Yu Yue , Zheng Hong , Cao Xu-Chen , Chen Da , Chen Ke-Xin , Chen Xi , Tang Nai-jun
Published: September 2022

Background

Perfluoroalkyl substances (PFASs) are a large family of synthetic chemicals, some of which are mammary toxicants and endocrine disruptors. Recent studies have implicated exposure to PFASs as a risk factor for breast cancer in Europe and America. Little is known about the role of PFASs with respect to breast cancer in the Chinese population.

Methods

Participants who were initially diagnosed with breast cancer at Tianjin Medical University Cancer Institute and Hospital between 2012 and 2016 were recruited as cases. The controls were randomly selected from the participants with available blood samples in the Chinese National Breast Cancer Screening Program (CNBCSP) cohort. Ultimately, we enrolled 373 breast cancer patients and 657 controls. Plasma PFASs were measured by an ultra-performance liquid chromatography (UPLC) system coupled to a 5500 Q-Trap triple quadrupole mass spectrometer. A logistic regression model with least absolute shrinkage and selection operator (LASSO) regularization was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) to assess the relationships between PFASs and breast cancer. The three most predictive variables in the LASSO model were selected from 17 PFASs, which was based on the optimal penalty coefficient (λ = 0.0218) identified with the minimum criterion. Additionally, Bayesian kernel machine regression (BKMR) and quantile g-computation models were applied to evaluate the associations between separate and mixed exposure to PFASs and breast cancer.

Results

Perfluorooctanesulfonic acid (PFOS) exhibited the highest concentration in both the cases and controls. Perfluorooctanoic acid (PFOA) and perfluoro-n-decanoic acid (PFDA) were positively associated with breast cancer, and perfluoro-n-tridecanoic acid (PFTrDA) was negatively associated with breast cancer according to both the continuous-PFASs and the quartile-PFASs logistic regression models. Of note, PFOA was associated with the occurrence of estrogen receptor (ER)-, progesterone receptor (PR)-, and human epidermal growth factor receptor 2 (HER2)-positive breast cancer (ORER+  = 1.47, 95% CI: 1.19, 1.80; ORPR+  = 1.36, 95% CI: 1.09, 1.69; ORHER2 = 1.62, 95% CI: 1.19, 2.21).

Conclusions

Overall, we observed that PFASs were associated with breast cancer in Chinese women. Prospective cohort studies and mechanistic experiments are warranted to elucidate whether these associations are causal.
Efficacy of different neoadjuvant treatment regimens in BRCA-mutated triple negative breast cancer: a systematic review and meta-analysis
Authors: Caramelo Olga , Silva Cristina , Caramelo Francisco , Frutuoso Cristina , Pinto Leonor , Almeida-Santos Teresa
Published: September 2022

Purpose

Triple negative breast cancer (TNBC) is an aggressive breast cancer strongly associated with BRCA mutation. Standard neoadjuvant chemotherapy remains the standard of care for early stage TNBC, the optimal chemotherapy regimen is still a matter of discussion. Other agents, such as poly-ADP-ribosyl polymerase inhibitors (PARPi) and anti-vascular endothelial growth factor (VEGF) antibodies were evaluated in the neoadjuvant setting. This systematic review and meta-analysis intend to evaluate the impact of neoadjuvant treatments in pCR rates in TNBC gBRCA mutation, beyond traditional standard chemotherapy.

Methods

PubMed, Clinicaltrials.gov, Cochrane CENTRAL, Embase and key oncological meetings for trials were searched for studies reporting neoadjuvant chemo-immunotherapy in BRCA positive TNBC.

Results

Out of 1238 records reviewed, thirty-one trials were included, resulting in a total 619 BRCA-mutated TNBC patients. In BRCA mutated TNBC patients who received cisplatin in monotherapy the proportion of patients who achieved pCR was 0.53 (95%CI [0.30, 0.76]), and when treatment combined standard chemotherapy and platin derivatives the proportion of pCR increased to 0.62 (95% CI [0.48, 0.76]). The group of patients treated with platin derivatives, anthracyclines ± taxanes achieved the highest proportion of pCR, 0.66. Patients treated with PARPi alone show a pCR proportion of 0.55 (95% CI [0.30, 0.81]); and when standard chemotherapy and platin derivatives were combined with PARPi the proportion of pCR did not vary.

Conclusions

Patients with BRCA mutated TNBC treated with cisplatin in monotherapy demonstrate inferior proportion in the pCR achievement when compared with standard chemotherapy plus platin derivates. The best pCR was achieved with platin derivates in association with anthracyclines ± taxanes. No difference in pCR was found between PARPi alone vs PARPi with standard chemotherapy.