bluuebunny/crossref_metadata_2025 huggingface dataset:
Fasting blood glucose as a predictor of progressive infarction in men with acute ischemic stroke
Authors: Yu Qiulong , Mao Xiaocheng , Fu Zhihui , Luo Si , Huang Qin , Chen Qianxi , Li Shumeng , Zhang Jinchong , Qiu Yuexin , Wu Yuhang , Fang Pu , Hong Daojun , Lin Jing
Published: October 2022

Objective

Blood glucose is related to early neurological deterioration in acute ischemic stroke, but multiple mechanisms are involved in early neurological deterioration, such as progressive infarction. This study aimed to determine whether fasting blood glucose (FBG) is an independent predictor of progressive infarction.

Methods

From April 2017 to December 2020, we retrospectively enrolled 477 patients with acute ischemic stroke within 48 hours of onset. Demographic characteristics, clinical information, neuroimaging characteristics, and laboratory data were collected after admission.

Results

We found that 147 (30.8%) patients had progressive infarction. Multiple regression analysis showed that high FBG concentrations (>7.66 mmol/L) were independently associated with progressive infarction. Sex subgroup analysis showed that high FBG concentrations were an independent predictor of progressive infarction in male patients (odds ratio, 2.559; 95% confidence interval, 1.279–5.121). In a receiver operating characteristic curve analysis, FBG concentrations were a predictor of progressive infarction in all cases, especially in male patients. The cutoff value of FBG in all patients and men was 7.155 mmol/L.

Conclusions

FBG is an independent predictor of progressive infarction in patients with acute ischemic stroke within 48 hours of onset, especially in men. Patients with FBG concentrations ≥7.155 mmol/L are more likely to develop progressive infarction.
Evaluating the Impact of the Pandemic Crisis on the Aviation Industry
Authors: Ye Qing , Zhou Rongting , Asmi Fahad
Published: October 2022

This paper investigates the intellectual structure of the literature addressing “epidemic/pandemic” and “aviation industry” through a bibliometric approach to the literature from 1991 to 2021. The final count of 856 publications was collected from Web of Science and analyzed by CiteSpace (version 5.8.R1) and VOS Viewer. Visualization tools are used to perform the co-citation, co-occurrence, and thematic-based cluster analysis. The results highlight the most prominent nodes (articles, authors, journals, countries, and institutions) within the literature on “epidemic/pandemic” and “aviation industry.” Furthermore, this study conceptualizes and compares the growth of literature before theCOVID-19 pandemic and during the COVID-19 (“hotspot”) era. The conclusion is that the aviation industry is an engine for global economics on the road to recovery from COVID-19, in which soft (human) resources can play an integral part.
The (Silk) Road Less Travelled: East Asian Studies and National Identity Formation in Modern Turkey
Authors: Ergenç Ceren
Published: October 2022

Regional studies in Turkey have long focused on Europe and the Middle East, with which Turkey has traditionally been associated. East Asian studies seem to remain out of the spotlight. This study claims firstly that different phases of Asian studies scholarship in Turkey have all been geared towards confirmation and validation of the process of Turkish national identity formation. Secondly, this process also reflects the Western-centrism of Turkish academic knowledge production.

This paper presents a periodization of Asian Studies in Turkey in three phases to contextualize and demonstrate these claims. During the first phase of the early republican years, the first Sinology departments were expected to actively contribute to writing Turkish national history. Throughout the second phase of the Cold War years, Turkey found itself in both political and intellectual isolation. In the final phase of post-Cold War globalization, the scope of regional studies scholarship expanded to include East Asia. Despite this development, academic scholarship in Turkey still suffers from Western-centrism and it is not able to directly communicate with East Asia. Knowledge production on East Asia in Turkey is still filtered through the theoretical framework of the Western Anglophone academic world.
Diplomatic Relations on the Tang Frontier: Pugu Yitu Tomb Inscription
Authors: Tezel Aybike Şeyma
Published: October 2022

The Tang period (618–907) stands out as one of the most important chapters of the history of early Inner Asia, where bilateral diplomatic interactions on the Chinese – Inner Asian frontier reached a high point. Since its establishment, the Tang pursued close relations with the neighboring Türk Qaghanate and various other Turkic and Mongolic speaking groups in the Inner Asian steppes. These relations, sometimes friendly, other times hostile, were to a great extent recorded in the official histories, a genre of historical writing that was systematized with the establishment of Historiography Office at the Tang court. As political texts written with particular agendas, official histories present certain limitations. Recent archaeological research in both China and Inner Asia provide a different line of evidence for the study of diplomatic relations between China and Inner Asia. This paper aims to discuss the history of Pugu, a Turkic speaking Inner Asian group who had submitted to the Tang in the seventh century, through an analysis of the tomb inscription of Pugu Yitu, then leader of the Pugu, and an army general and court official of the Tang.
The Application of Bystander Intervention Scripts: Implications for Guardianship in Action
Authors: Butler Leah C. , Graham Amanda , Fisher Bonnie S.
Published: October 2022

Responding to high rates of interpersonal victimization and perpetration among adolescents, schools have implemented bystander intervention (BI) training to educate students to intervene to prevent or stop violence. These trainings function much like an application of scripts for guardianship in action. The current study builds on the overlapping and complementary bodies of BI and routine activities research by testing whether participation in BI training, namely Green Dot (GD), influences individuals’ underlying ability to intervene. Using four years of survey data collected from high school students ( N = 2,374–3,443), we use item response theory to model the difficulty of engaging in different BI behaviors. We then estimate multivariate ordinary least squares regression models, one for each year, to estimate the effect of GD training on students’ ability to intervene. The item response theory results show that BI behaviors differ in terms of how “difficult” they are for respondents to engage in. Findings show that in each year, GD training increased students’ underlying ability to intervene. Our findings suggest BI training and guardianship in action scripts should take into account this varying difficulty of intervention behaviors to best train individuals for successful intervention to prevent victimization.
The Power of Empathy: Experimental Evidence of the Impact of Perspective-Focused Interventions on Support for Prison Reform
Authors: Harney Jessie
Published: October 2022

As a result of COVID-19, individuals have experienced situations that may help them relate to others, including more limited ability to interact with their environment. Thus, this survey experiment ( N = 2,229) tests whether perspective-focused interventions can help increase support for prison reform. Findings suggest that perspective-getting (providing the perspective of an incarcerated individual via a narrative description of dealing with confinement) increased self-reported support for prison reform initiatives, compared with information only. In addition, a perspective-taking prompt—nudging participants to put themselves in the shoes of the incarcerated individual when reading their narrative—may help boost intention to take action in support of prison reform. Future avenues for research and implications are discussed.
Positive Psychology and Positive Criminology: Similarities and Differences
Authors: Elisha Ety , Ronel Natti
Published: October 2022

The purpose of this review is to highlight the similarities and differences between positive psychology and positive criminology—both relatively new concepts that represent an optimistic view of human beings and their ability to recover—while calling for a change of focus in the discourse and research of their respective fields. To this end, we first present a brief overview of each of these perspectives, along with findings of studies that confirm their assumptions, and then address their similarities and differences, with an emphasis on positive criminology which is our area of expertise. We conclude that both approaches seek to improve the quality of life and well-being of individuals, families, and communities through the development of human strengths and skills and the provision of social assistance.
Rapport and Relationship Building in a Therapeutic Community: Examining the Dynamic Between Correctional Officers and Incarcerated Persons
Authors: Abdel-Salam Sami , Antonio Michael E. , Bratina Michele P. , Kilmer Ashley
Published: October 2022

Correctional officers (COs) are vital to prison safety. While focused on security, some believe COs should also be trained to engage in the rehabilitation of incarcerated persons by offering motivation and support. This study examined incarcerated persons’ perceptions of COs working in a prison-based therapeutic community (TC). Data were gathered through qualitative interviews with individuals detained in a state correctional system for men. Findings revealed several themes related to incarcerated persons’ perceptions of COs’ knowledge toward treatment, their experiences and interactions with COs, and recommendations about how to improve the role of COs as therapeutic agents of change. Practical opportunities for implementing correctional research and practice using a positive criminology perspective are considered.
Student Mentors of Incarcerated Persons: Contribution of a Mentoring Program for Incarcerated Persons
Authors: Timor Uri , Peled-Laskov Ronit , Golan Etty
Published: October 2022

This study evaluates the impact of a student program for mentoring incarcerated persons. Mentoring has multiple goals for both incarcerated persons and mentors; this article focuses on its contributions to incarcerated persons. The program encourages incarcerated persons to think positively and constructively, apply anger management, and learn about the normative society they will enter. Twenty-one incarcerated persons participated in semi-structured in-depth interviews in this qualitative research. The findings show that the students eventually became significant others for the incarcerated persons, most of whom reported on forming excellent relations with the students, and learning to act more deliberately and less violently due to the students. They also described reducing their self-absorption, expanding their horizons, and better understanding their criminal choices. Some mentioned acquiring more structured worldviews and improving their behavior. The findings point to significant benefits gained from the incarcerated person–student interaction in the mentoring framework, and the importance of expanding the program.
High frequency of Depressive Disorders and Suicidal Phenomena in Late-Stage Parkinson´s Disease – A Cross-Sectional Study
Authors: Chendo Inês , Fabbri Margherita , Godinho Catarina , Simões Rita Moiron , Sousa Catarina Severiano , Coelho Miguel , Voon Valerie , Ferreira Joaquim J.
Published: October 2022

Background

Depressive disorders (DD) are widely recognized as one of the most frequent neuropsychiatric disorders in Parkinson´s disease. Patients with late-stage Parkinson´s disease (LSPD) continue to be a neglected population, and little is known about DD frequency in LSPD.

Objectives

To determine the frequency of DD in LSPD patients through a clinical diagnostic interview (CDI) and according to diagnostic DSM- 5 criteria. Secondary objectives were to determine the predictive ability of depressive scales to detect DD, to identify potential predictors of DD in LSPD and, to evaluate suicidal phenomena in LSPD.

Methods

A cross-sectional study including LSPD patients (≥7 years from symptom onset and Hoehn and Yahr scale score >3 or a Schwab and England scale score <50% in the ON condition) was conducted. Patients were subjected to psychiatric, neurological, and neuropsychological evaluations. Six depression scales were applied.

Results

92 LSPD patients were included. 59.78% of LSPD patients had a current diagnosis of DD according to CDI, 38.04% patients had a diagnosis of major depressive disorder, and 21.72% non-major depressive disorder. Suicidal ideation was present in 36.96% of patients. All applied scales were able to detect depressive disorders.

Conclusions

More than half of LSPD patients met DD diagnostic criteria and over one-third were diagnosed with major depressive disorder. Overall, the LSPD population seem to have a unique clinical phenotype regarding the frequency and features of DD, whose early identification and treatment could improve the quality of life of patients and caregivers.
Gender Composition and the Symbolic Value of Occupations: New Evidence of a U-shaped Relationship between Gender and Occupational Prestige Based on German Microdata
Authors: Krueger Sabine , Ebner Christian , Rohrbach-Schmidt Daniela
Published: October 2022

Occupational prestige is an important yet understudied factor in gender labour market inequality. This study examines the relationship between the gender composition of occupations and the prestige of those occupations, and investigates whether men and women differ in their evaluations. A multilevel analysis based on German microdata generated two key findings. First, occupations that are predominantly male or female tend to be rated as more prestigious than mixed-gender occupations when controlling for pay and educational requirements, suggesting a segregation premium in the symbolic valuation of work in Germany. Second, there is no evidence of a gendered in-group bias in Germany; both men and women consider gender-segregated occupations to be more prestigious, with no preference for occupations dominated by their own gender.
Discursive construction of migrant otherness on Facebook: A distributional semantics approach
Authors: Yantseva Victoria
Published: October 2022

This work aims to study the construction of migrant categories and immigration discourse on Swedish-speaking Facebook pages in the last decade. It combines the insights from computational linguistics and distributional semantics approach with those from discursive psychology to explore a corpus of more than 1 M Facebook posts. This allows one to compare the meanings of labels denoting various categories of migrants and identify the key interpretative repertoires used to discuss the immigration topic. The study finds that the ‘immigrant’ category has stronger association with potential costs, benefits and threat to the host society, while the ‘refugee’ category is presented as in need of support and solidarity. Nevertheless, objectification and exclusionary rhetoric are used in relation to both categories, although in different ways, while the immigration issue is often interpreted as a matter of Sweden’s national concern rather than as a part of people’s actual experiences and life paths.
Hepatoprotective effect of ferulic acid and/or low doses of γ-irradiation against cisplatin-induced liver injury in rats
Authors: Esmat Marwa A , Osman Ahmed , Hassan Rasha E , Hagag Sanaa A , El-maghraby Tarek K
Published: October 2022

The therapeutic efficacy of cisplatin (CIS) is limited owing to its hepatotoxic side effects. The current study aimed to investigate the protective impact of ferulic acid (FA) and low-doses of γ-irradiation (LDR) against CIS-prompted hepatotoxicity in rats. Adult male Swiss albino rats were divided into eight groups: untreated group; FA, LDR, and CIS treated groups; and combinations of one or more of the above treatments. Post-treatment analyses included measuring redox markers like SOD and CAT activity, NO free radical content, and lipid peroxidation in liver tissue. Serum aminotransferase activities were also determined. Additionally, gene transcript levels of liver NF-ҡB-P65, caspase-1, COX-2, and IL-1β were quantified. Moreover, immunohistochemistry for caspase-3 and histopathological examinations were estimated in liver tissue. Our findings revealed increased levels of oxidative stress along with a significant reduction in anti-oxidative responses and a significant increase in serum aminotransferase activities in the CIS-intoxicated group. A similar increase was also observed in COX-2 and IL-1β transcript levels and caspase-3 enzyme activity, besides a decrease in transcript levels of NF-ҡB-p65 and caspase-1, indicating an overall inflammatory trend and an increase in the apoptotic shift. The co-administration of FA and/or treatment with LDR has ameliorated the hepatotoxic effect induced by CIS. The histopathological investigation of liver tissues confirmed this ameliorating action of these adjuvant therapies against CIS toxicity. In conclusion, it is plausible to suggest that the hepatoprotective effects of co-administration of FA and/or LDR against CIS-induced hepatotoxicity are attributed to the possession of anti-oxidative, anti-inflammatory, and anti-apoptotic capabilities.
A Case of Daratumumab-Induced Significant Decrease in Donor-Specific HLA Antibodies and Remission Induction Before Haploidentical Stem Cell Transplantation in a Refractory B-ALL Patient
Authors: Li Xin , Zhu Haibo , Sui Tao , Zhao Xingli , Deng Qi
Published: October 2022

Objective:

To explore the method of eliminating donor-specific anti-HLA antibodies (DSA) in haploidentical stem cell transplantation (haplo-SCT).

Methods:

We present a refractory B-cell acute lymphoblastic leukemia (ALL) patient who had strongly positive DSA, but had no human leukocyte antigen–matched donor. Although CD38 expression on leukemia cells was negative, daratumumab combined with etoposide and venetoclax therapy was chosen for her.

Results:

She achieved a significant decrease in DSA levels and complete remission on the combination therapy with daratumumab. She then received a haplo-SCT from a daughter as a donor and had a successful engraftment of donor stem cell. In haplo-SCT, strongly positive DSA levels, directed against donor HLA antigens, could be significantly reduced by daratumumab therapy before transplantation and successfully bridge subsequent haplo-SCT.

Conclusion:

Although CD38 expression is negative in leukemia cells, refractory B-ALL patients may still benefit from combination therapy with daratumumab. We need further clinical observation.
Formalising the Informal through GST: Evidence from a Survey of MSMEs
Authors: Ghosh Sangeeta
Published: October 2022

In this study, the processes and channels through which an indirect tax reform has impacted micro, small and medium enterprises in India are identified using a field survey of small businesses. The Goods and Services Tax introduced in 2017 in India has been a significant departure from the past to impact businesses and business practices in a way that introduces formal practices into the everydayness of small businesses. This study shows that established informal mechanisms have been disturbed, which has led to coping mechanisms that have borne adverse outcomes for small businesses and workers involved in them. The benefits from such a move have been rather limited for small businesses. This study advocates that the quest to transition from an informal to a formal economy is one where many small steps must be first identified, and necessary handholding and training for the vulnerable units must be provided for inclusive development.
Afghan Refugee Resettlement in the United States: Implications for Service Provision
Authors: Rai Abha , Held Mary Lehman , Vidal de Haymes Maria
Published: October 2022

Afghan refugees experienced a surge of crisis in August 2021 after the U.S. troops withdrew operations in Afghanistan, leaving them exposed to the harms of the Taliban regime. Sudden evacuation led to family separation and uncertainty. Furthermore, the trauma of leaving loved ones behind and resettling into a new country of which this group had limited familiarity could have challenges in terms of integration. Through our brief practice note, we discuss the challenges faced by Afghan refugees resettling in the United States during these difficult times, along with implications for practitioners and service providers. We highlight strategies to ensure culturally responsive service provision for these refugees.
Multidrug-Resistant Bacteria in Hospital Wastewater of the Korle Bu Teaching Hospital in Accra, Ghana
Authors: Addae-Nuku Daisy S , Kotey Fleischer CN , Dayie Nicholas TKD , Osei Mary-Magdalene , Tette Edem MA , Debrah Philip , Donkor Eric S
Published: October 2022

Background:

Antimicrobial resistance (AMR) is one of the top 10 public health threats. One approach to tackling the AMR menace could involve expanding the range of AMR surveillance domains to include hospital wastewater (HWW), a domain that has largely been overlooked by researchers.

Aim:

To evaluate the occurrence of multidrug-resistant bacteria in hospital wastewater of the Korle Bu Teaching Hospital (KBTH).

Methodology:

This was a longitudinal study involving 288 HWW samples consecutively collected across 12 weeks from the pool of wastewater emanating from 2 critical care units of KBTH—The Child Health Unit and the Maternity Unit—on Mondays and Thursdays, each week. The samples were cultured for bacteria, which were identified using the Matrix-Assisted Laser Desorption/Ionization-Time of Flight (MALDI-TOF) technique and subjected to antimicrobial susceptibility testing via the Kirby-Bauer method.

Results:

In total, 294 bacteria of 23 different types, all being Gram-negative, were isolated from the 288 samples. The predominant ones were Escherichia coli (30.6%, n = 90), Klebsiella pneumoniae (11.2%, n = 33), Citrobacter freundii (10.9%, n = 32), Alcaligenes faecalis (5.8%, n = 17), and Pseudomonas mendocina (5.4%, n = 16). The prevalence of multidrug resistance among the isolates was 55.4% (n = 163). Moreover, the prevalence of extended-spectrum beta-lactamase (ESBL) producers was 15.6% (n = 46). E. coli accounted for the most ESBL-producing organisms (28.9%, n = 26).

Conclusion:

The wastewater generated by the Maternity and Child Health Units of KBTH harbored a wide range of multidrug resistant bacteria, with a good proportion of these being ESBL producers, and the predominant one being E. coli. The study thus identifies the wastewater of KBTH as an important source of multidrug resistant organisms, and underscores the significance of appropriate treatment of wastewater of the hospital and other clinical, and related settings prior to its discharge.
Planetary activism at the end of the world: Feminist and posthumanist imaginaries beyond Man
Authors: Karkulehto Sanna , Koistinen Aino-Kaisa , Ugron Nóra
Published: October 2022

We are currently experiencing a planetary crisis that will lead, if worst comes to worst, to the end of the entire world as we know it. Several feminist scholars have suggested that if the Earth is to stay livable for humans and nonhumans alike, the ways in which many human beings – particularly in the wealthy parts of the world, infested with Eurocentrism, (neo)colonialism, neoliberalism, and capitalism – inhabit this planet requires radical, ethical, and political transformation. In this article, we propose that feminist theory, particularly feminist posthumanities, and Black feminist and decolonial thought, together with creative practices such as writing, have much to contribute to transformative planetary activism that imagines different and other kinds of worlds and futures based on an ethical consideration of nonhuman others and collective caring for the planet.
Cladribine and pregnancy in women with multiple sclerosis: The first cohort study
Authors: Dost-Kovalsky Karen , Thiel Sandra , Ciplea Andrea I , Gold Ralf , Hellwig Kerstin
Published: October 2022

The aim of this study was to investigate the effects of cladribine use, in the last 6 months prior (56.4%) to or after (43.6%) the last menstrual period in a population of women with multiple sclerosis, on pregnancy outcomes and relapse rate during pregnancy and postpartum. Data were collected in regular interviews. Of 39 pregnancies, 27 babies have been born so far and one major congenital malformation occurred. Disease control was excellent among the cohort both during pregnancy and the postpartum period, with only one relapse recorded in each time period. Although most newborns are healthy, reinforced counselling on effective contraception 6 months after last cladribine dosing is necessary.

Background:

As cladribine is contraindicated in pregnancy, data to pregnancy outcomes and disease control are scarce.

Objective:

To investigate the effects of Cladribine use, in the last 6 months prior (56.4%) to or after (43.6%) the last menstrual period in a population of women with multiple sclerosis, on pregnancy outcomes and relapse rate during pregnancy and postpartum.

Methods:

Data were collected prospectively in regular telephone interviews.

Results:

Of 39 pregnancies, 27 babies have been born so far and one major congenital malformation occurred. Disease control was excellent among the cohort both during pregnancy and the postpartum period, with only one relapse recorded in each time period.

Conclusions:

Although most newborns are healthy, reinforced councelling on effective contraception 6 months after the last cladribine dosing is necessary.
Anxiety in children and youth with autism spectrum disorder and the association with amygdala subnuclei structure
Authors: Hennessy Abagail , Seguin Diane , Correa Susana , Wang Jianan , Martinez-Trujillo Julio C , Nicolson Rob , Duerden Emma G
Published: October 2022

Autism spectrum disorder (ASD) is clinically characterized by social and communication difficulties as well as repetitive behaviors. Many children with ASD also suffer from anxiety, which has been associated with alterations in amygdala structure. In this work, the association between amygdala subnuclei volumes and anxiety was assessed in a cohort of 234 participants (mean age = 11.0 years, SD = 3.9, 95 children with ASD, 139 children were non-autistic). Children underwent magnetic resonance imaging. Amygdala subnuclei volumes were extracted automatically. Anxiety was assessed using the Screen for Child Anxiety Related Disorders, the Child Behavior Checklist, and the Strength and Difficulties Questionnaire. Children with ASD had higher anxiety scores relative to non-autistic children on all anxiety measures (all, p < 0.05). Anxiety levels were significantly predicted in children with ASD by right basal (right: B = 0.235, p = 0.002) and paralaminar (PL) (B = −0.99, p = 0.009) volumes. Basal nuclei receive multisensory information from cortical and subcortical areas and have extensive projections within the limbic system while the PL nuclei are involved in emotional processing. Alterations in basal and PL nuclei in children with ASD and the association with anxiety may reflect morphological changes related to in the neurocircuitry of anxiety in ASD.

Lay abstract

Autism spectrum disorder (ASD) is clinically characterized by social communication difficulties as well as restricted and repetitive patterns of behavior. In addition, children with ASD are more likely to experience anxiety compared with their peers who do not have ASD. Recent studies suggest that atypical amygdala structure, a brain region involved in emotions, may be related to anxiety in children with ASD. However, the amygdala is a complex structure composed of heterogeneous subnuclei, and few studies to date have focused on how amygdala subnuclei relate to in anxiety in this population. The current sample consisted of 95 children with ASD and 139 non-autistic children, who underwent magnetic resonance imaging (MRI) and assessments for anxiety. The amygdala volumes were automatically segmented. Results indicated that children with ASD had elevated anxiety scores relative to peers without ASD. Larger basal volumes predicted greater anxiety in children with ASD, and this association was not seen in non-autistic children. Findings converge with previous literature suggesting ASD children suffer from higher levels of anxiety than non-autistic children, which may have important implications in treatment and interventions. Our results suggest that volumetric estimation of amygdala’s subregions in MRI may reveal specific anxiety-related associations in children with ASD.
Perceptions of racial essentialism and social identity threat
Authors: Cipollina Rebecca , Pereira-Jorge Izilda , Sanchez Diana T.
Published: October 2022

While past research documents essentialist beliefs’ (i.e., believing social groups have inherent, unchangeable traits) impact on prejudice, no research has explored if stigmatized groups perceive essentialism as indicative of bias. With a sample of participants diverse in race and sexual orientation, we document that endorsers of racial essentialism were perceived as more likely to be racist and also as more likely to be sexist and heterosexist, relative to nonendorsers (Studies 1–2). As some essentialist beliefs about sexual orientation are associated with progay attitudes, another experiment parsed out dimensions of racial essentialism (i.e., natural kind and entitative beliefs) and examined differences in White sexual minorities’ expectations of bias from this race-based cue. Findings indicate that both essentialism dimensions elicited identity threat with potential consequences for sexual minorities’ desire to conceal their sexual orientation; thus, we broaden conceptualizations of cues that elicit identity threat while exploring nuances of the impact of perceiver identity and essentialism type.
Direct estimation of evolutionary power spectral density of nonstationary winds: A unified formulation
Authors: Hu Liang , Kareem Ahsan
Published: October 2022

Estimating the evolutionary power spectral density (EPSD) of non-stationary winds (e.g., tropical storms and downbursts) is necessary to predict the response of structures under such extreme winds. Following the review of the existing direct estimation methods of EPSD, this paper offers a two-step unified formulation, i.e., raw estimation and associated error reduction. The raw estimation is expressed in terms of a time-frequency transform with a general kernel function. It is shown that if the kernel function is described by a time-frequency analysis tool such as the short-time Fourier transform, the wavelet transform, and the S-transform, the generalized raw EPSD estimation becomes a particular case of the existing methods. The unified estimation method presented here can be viewed as a filter bank with adjustable time and frequency resolution. The analysis of error in the raw estimation is carried out on the bias and random errors accounting for the approximation in both the time and frequency domains. Various techniques for reducing such errors are then summarized and recast in the unified formulation, including series expansion, short-time window smoothing, and multi-tapering. Based on the unified perspective, a discussion and some prospects of EPSD estimating are provided.
Does local income and wealth inequality affect mortality? A register-based fixed effects study of 58 million person-years
Authors: Jørgensen Ruth E. , Hovde Lyngstad Torkild
Published: October 2022

Aim: The Income Inequality Hypothesis asserts that income inequality causes negative health burdens within wealthy nations. We aimed to test the hypothesis in Norway, examining the relationship between both income and wealth inequality, net of individual economic resources, and individual all-cause mortality. To this day, little is known about the association between wealth inequality and mortality. In Norway, wealth is far more unequally distributed than income and can be a more prevalent indicator of long-term financial security. Methods: We estimated discrete-time event history models from Norwegian register data, covering all Norwegian-born men and women aged 25–84 years during the period 1993–2013. We include fixed effects at the municipal level, adjusting for time-invariant characteristics in the local area. Our data contain approximately 58.5 million person-year observations after sample restrictions. Results: Overall, increased income and wealth inequality (measured using Gini coefficients of individuals’ pensionable income and net worth) is not associated with higher mortality risk in Norway. With a one percentage point increase in income inequality, odds ratio (OR) for mortality was estimated at 0.998 (95% confidence interval (CI) 0.996–1.001) for men and 1.002 (95% CI 0.999–1.006) for women. Corresponding OR from increased wealth inequality was 0.998 (95% CI 0.997–1.000) for men and 0.999 (95% CI 0.998–1.001) for women. Conclusions: Our results raise further doubts about the existence of a contextual effect of economic inequality on health, at least in a Nordic setting. Extensive health policies, relatively generous benefits and high levels of trust could potentially function as a buffer against negative health consequences of increased economic inequality in Norway.
A template for conducting qualitative sales research in the Middle East
Authors: Malshe Avinash , Al-Khatib Jamal
Published: October 2022

Potential challenges in conducting international sales research, coupled with the lack of systematic guidance currently prevent western sales scholars from conducting research in emerging market contexts. The authors draw upon (a) their decade-long experience in conducting qualitative sales research in the Middle East (ME), as well as (b) depth interview data they collected specifically for this paper from eleven academics engaged in doing sales research in that region to propose a three-step framework for conducting qualitative sales research within the ME. The exclusivity of this framework to the ME context is rooted in its responsiveness to the unique elements and idiosyncrasies inherent within the ME culture. In addition to offering a systematic guidance, the framework implies that it is not the research expertise of the western scholars, but their ability to understand and respond to cultural nuances, and cultivate and employ soft skills such as communication, trust, relationship building, and/or mutual respect that may make or break their foray into conducting sales research in the ME markets.
Thermal aging and automotive oil effects on the performance of electron beam irradiated styrene butadiene rubber/waste and microwave devulcanized rubber blends
Authors: Raslan Heba A , Fathy ES , Abdel Aal SE
Published: October 2022

Replacement of virgin polymer with its waste become one of the special technique that capture the efforts of many researchers and industrialists alike. In this context, this work discussed the partial replacement of waste tire rubber (WR) and microwave devulcanized rubber (DWR) at different ratios on the properties of virgin styrene butadiene rubber (SBR) as one of the most essential components of synthetic rubber in the tire production. Fixed percent of tetramethylthiuram disulfide and spindle oil were added at the first, then the WR mixture was exposed to different microwave times. Microwave devulcanization value at time 6 min gave the highest devulcanization percent. The prepared blends were exposed in an electron beam accelerator (EB) at 50 and 100 kGy. FTIR, different mechanical parameters, thermal stability (TGA) and scanning electron microscopy of the fabricated specimens have been explained. Effect of automotive oil and thermal aging at different temperature, 70oC and 100oC on the tensile strength and elongation at break (E%) of the unirradiated and irradiated prepared blends have been estimated. Mechanical measurements of all examined specimens after thermal aging and oil immersion were least affected. Moreover, these factors before and after oil dipping and thermal aging revealed that unirradiated and irradiated SBR/DWR blends have superior properties than SBR/WR.
Institutional Design and Policy Responsiveness in US States
Authors: LaCombe Scott J.
Published: October 2022

There is significant disagreement on the moderating role of institutions on policy responsive- ness, yet overwhelmingly research in state politics has focused on single institutions. This project leverages a new aggregate scale of state institutions to evaluate if the collective insti- tutional context moderates the influence of public opinion on policy. I use a recently released latent scale of institutional context and find that high levels of accountability pressure strongly strengthen public opinion’s influence on policy for both economic and social policy, while the strength of a state’s checks and balance system is largely unrelated to policy responsiveness. These results demonstrate the importance of incorporating aggregate institutional design into our understanding of the role of institutions in state politics, and that collectively institutions play a large role in determining how public opinion is translated into policy.
Emerging role of N6-methyladenosine RNA methylation in lung diseases
Authors: Xu Limin , Zhou Lingyan , Yan Chenxin , Li Liqin
Published: October 2022

In recent years, with the increase of air pollution, smoking, aging, and respiratory infection, the incidence rate and mortality of lung diseases are increasing annually, which has become a major hazard to human health. N6-methyladenosine (m6A) RNA methylation is the most abundant modifications in eukaryotes, and such modified RNA can be specifically recognized and combined by m6A recognition proteins and then mediate RNA splicing, maturation, enucleation, degradation, and translation. More and more studies have revealed that the m6A modification is involved in the pathogenesis and development of some diseases; however, the mechanisms of m6A in lung diseases are poorly understood. In this review, we summarize the latest progress in the biological function of m6A modifications in lung diseases and discuss the potential therapeutic and prognostic strategies. The dysregulation of global m6A levels and m6A regulators may affect the occurrence and development of asthma, chronic obstructive pulmonary disease, lung cancer, and other lung diseases through inflammation and immune function. In lung cancer, this modification has an important impact on malignant cell proliferation, migration, invasion, and drug resistance. In addition, abnormally changed m6A-modified proteins in lung cancer tissue samples and circulating tumor cells (CTCs) may be used as diagnostic and prognostic markers of lung cancer. Models composed of multiple m6A regulators can be used to evaluate the risk prediction or prognosis of asthma and pulmonary fibrosis. In general, the in-depth study of m6A modifications is a frontier direction in disease research. It provides novel insights for understanding of the molecular mechanisms underlying disease occurrence, development, and drug resistance, as well as for the development of effective novel therapeutics.
Adapting the Pillar Integration Process for Theory Development: The Theoretical Model of Healthcare Factors Influencing Quality of Life in Cancer Survivorship
Authors: Drury Amanda , Sheila Payne , Anne-Marie Brady
Published: October 2022

Mixed methods research offers a unique opportunity to advance understanding of a phenomenon. However, practical guidance on the use of mixed methods to develop theoretical frameworks is limited. We present a novel adaptation of the Pillar Integration Process (PIP) to support development and refinement of a theoretical framework explaining the processes by which healthcare factors influence cancer survivors’ quality of life. Deductive integration of quantitative and qualitative data, guided by an a priori conceptual model, illuminates the nuances of the relationship between the concepts of interest, producing a theoretical framework, the Model of Healthcare factors influencing Quality of Life in Cancer Survivorship (MoHaQ-CS).
Fixing Hands, Breaking Backs: The Ergonomics and Physical Detriment of the Hand Surgeon
Authors: Tarabishy Sami , Brown Geoffrey , Hudson H. Todd , Herrera Fernando A.
Published: October 2022

Background:

Work-related musculoskeletal disorders in surgeons have been well documented. Hand surgeons, however, represent a unique population of surgical subspecialists due to frequent use of operative magnification. Thus, we aim to examine the contributing factors, types, and frequencies of work-related musculoskeletal injuries experienced by hand surgeons.

Methods:

A Research Electronic Data Capture survey including 12 demographic and 13 Nordic Musculoskeletal Injury Questionnaire questions was emailed twice to all active members of the American Association for Hand Surgery (AAHS). Data collection remained open for 30 days.

Results:

Ninety-six of 1228 AAHS members (8%) responded. Respondents were predominantly attendings (88, 91.7%), male (67, 69.8%), in academic practice (48, 50%), and in the age range of 35 to 44 years (34, 35.4%). Sixty-nine respondents (71.9%) attribute discomfort to their profession. Pain (56, 82.4%) and stiffness (46, 67.6%) were the most frequent symptoms, most common in the neck and wrist/hand regions. Fifty-nine (61.5%) respondents had acute (<1 week) discomfort, with onset most frequently reported after surgery (45, 48.9%). Thirty-two (34.8%) of the respondents state they worry these symptoms will hinder their ability to perform surgery in future. Sixteen (16.7%) respondents sustained a musculoskeletal injury directly related to work. Exercise was the most popular nonmedical therapy, while over-the-counter medications were the most popular medical therapy.

Conclusion:

The unique ergonomics of hand surgery, including frequent use of loupes and microscopes, appear detrimental to the surgeons’ health and career longevity. Further research will allow for the development of preventative measures, with the goal of facilitating longer, more productive careers for hand surgeons.
Does variability in recognition memory scale with mean memory strength or encoding variability in the UVSD model?
Authors: Spanton Rory W , Berry Christopher J
Published: October 2022

The unequal variance signal detection (UVSD) model of recognition memory assumes that the variance of old item memory strength (σo) is typically greater than that of new items. It has been suggested that this old item variance effect can be explained by the encoding variability hypothesis. However, Spanton and Berry (2020) failed to find evidence for this account, suggesting that σo may simply scale with mean memory strength ( d) in the UVSD model. Experiments 1 and 2 examined the effects of encoding variability and strength scaling on old item variance by creating conditions in which mean memory strength and variability in item characteristics was either low or high in 2 × 2 factorial designs. In Experiment 1, overall strength determined estimates of σo, with no effect of item characteristic variability. The same effect of overall strength was found in Experiment 2; there was also a significant effect of item characteristic variability, although this manipulation also had some effect on d and was therefore partially confounded. Experiment 3 similarly found a simultaneous increase in old item variance and memory strength in a design using mixed item characteristic variability conditions in a single-study/test block. We conclude that old item variance increases with mean memory strength in the UVSD model, with uncertainty about the effects of encoding variability, and that future explanations of the old item variance effect should bear this in mind.
Improving the Bias of Comparator Methods in Analytical Performance Assessments Through Recalibration
Authors: Pleus Stefan , Eichenlaub Manuel , Gerber Thomas , Eriksson Boija Elisabet , Makris Konstantinos , Haug Cornelia , Freckmann Guido
Published: October 2022

Background:

In analytical performance studies, the choice of comparator method plays an important role, as studies have shown that there exist relevant systematic differences (bias) between laboratory analyzers. The feasibility of retrospective recalibration of measurement results through comparison with methods or materials of higher metrological order to minimize bias was therefore assessed.

Method:

Existing data from performance studies of continuous and blood glucose monitoring systems were retrospectively analyzed. Comparison with a higher-order method was performed for two different data sets. In both cases, subject samples were measured, and a subset was also measured on a higher-order method. Recalibration based on higher-order materials (standard reference material [SRM]) was conducted for two different data sets containing results from SRM and subject samples. Linear regression analysis was performed for each device separately. Resulting equations were applied to the respective complete data set of subject samples. Bias between devices in a data set across all subject samples was assessed before and after recalibration.

Results:

Bias between devices was reduced from −3.6% to +0.6% in one data set and from +11.0% to +0.3% in the other by recalibration based on higher-order method. Using higher-order materials, bias was also reduced by recalibration, but mixed results were found: Bias was reduced from −3.1% to −0.1% in one data set and from −4.3% to −2.7% in the other.

Conclusions:

Recalibration did lead to a decrease in bias and thus can reduce the impact of the choice of comparator method. The procedure should be verified in a prospectively designed setting.
Single-Surgery Co-Implantation of Autologous Primary Articular Chondrocytes with Bone Marrow Cells in the Treatment of Articular Cartilage Lesions: Observations from the Operating Room on Tissue Input and Cell Output
Authors: de Jong Willem Cornelis , Penn Thomas William
Published: October 2022

Objective

Single-surgery variants of autologous chondrocyte implantation to repair cartilage are emerging, but practical data on such procedures are scarce. We set out to describe a 1-stage autologous chondrocyte co-implantation procedure and include quantitative characteristics of the biopsy tissues collected and of the cells obtained from those tissues in the operating room.

Design

Data concerning patient age, articular cartilage lesion size and location, as well as measurements of cartilage biopsy mass, bone marrow aspirate volume, and the cell yields harvested from those biopsies were intraoperatively collected for 141 patients.

Results

The mean patient age was 35.7 ± 9.8 years, and the mean total lesion size was 4.0 ± 3.1 cm2. Cartilage biopsy mass ranged from 0.19 to 2.0 gram and provided a mean yield of 1.23 × 106 chondrocytes/gram. Bone marrow aspirate volume ranged from 7.2 to 62 milliliters and provided a mean yield of 7.18 × 106 mononuclear cells/mL. The cell yields did not correlate with patient age, which ranged from 12 to 57 years. The mean primary chondrocyte supply was 272 thousand per cm2 of lesion, ranging from 10.4 thousand to 1.07 million per cm2. The total cell supply was kept at 9 million cells per cm2 of lesion by adding mononuclear cells to the chondrocytes. The mean tissue processing time was 100 ± 19 minutes, which was frequently used to perform concurrent interventions.

Conclusion

Single-surgery co-implantation of clinically relevant numbers of autologous primary articular chondrocytes and bone marrow cells is feasible for a wide range of ages and lesion sizes.