bluuebunny/crossref_metadata_2025 huggingface dataset:
THE ANALYSIS OF HIDEN FACTORS OF ARCHITECTURAL BARRIERS IN SOSNOWIEC MUNICIPIAL OFFICE FROM DISABLE PERSON POINT OF VIEW AS IMPORTANT FACTOR OF SUSTAINABLE ARCHITECTURE
Authors: Wolniak Radoslaw
Published: May 2021

Sustainable architecture is important to minimize negative impact of building. In this paper we concentrate on the problem from people with disability point of view. For them one of must important factors of sustainable architecture in public space is the problem connected with architectural barriers. In presented paper we conducted an analysis of hidden factors of architectural barriers on example of municipal office in Sosnowiec in southern part of Poland. During the research we analyzed the needs of persons with disabilities (perceived quality) and their assessment in terms of the level of quality of services provided by the municipal offices. We analyzed twenty fourth variables connected with architectural barriers in the municipal office and its neighborhood. We analyzed following variables: office location (easy to reach), a sufficient number of parking spaces, Z3 - parking spaces for the disabled near the entrance of the office, a clear marking of parking spaces for the disabled, watch for unauthorized persons occupying seats for the disabled, facilities for disabled people in the office, elevators for disabled guests, toilets suitable for disabled guests, handrails of the stairs, a system of ramps and ramps for the disabled, the doors have a width that allows entry wheelchair, anti-slip floor, equal level thresholds and floors, pavement and curbs around the office adapted for the disabled, website provides information for people with disabilities, website readable for people with visual disabilities, officials are turning to people with hearing difficulties by means of a suitable device, officials are talking with a person of hearing in a separate room, the office's employee who knew sign language, officials can serve the customers with guide dog, the office is equipped with a special frame to allow signing a document, the visually handicapped person allows the presence of a trusted person who acquainted her with the content of signed documents, the city council does not contain architectural barriers hindering the movement of physically disabled person, an overall assessment of architectural barriers at the office. Next we conducted factor analysis to identify main hidden factors of architectural barriers.
THE PERCEPTION OF ARCHITECTURAL BARRIERS IN SOSNOWIEC MUNICIPIAL OFFICE FROM DISABLE PERSON POINT OF VIEW
Authors: Wolniak Radoslaw
Published: May 2021

The paper concentrate on problems connected with problems of peoples with disability. The main aims of the paper is to measure the level of quality of service in the case of architectural barriers in municipal offices by peoples in disability. We made following hypothesis: the types of disability significantly affects the perception of quality of services in municipal office regarding architectural barrier. The problem of satisfaction of people with disability in the case of architectural barriers in municipal office in Sosnowiec was analyzed from type of disability point of view. We distinguished five main types of disability in the paper: sensory impairment – a lack, damage or disorder of sensory analysers’ function (this category includes the blind, the visually impaired, the deaf, hard of hearing persons and people with visual and auditory perception disorders); intellectual impairment – mental retardation; social functioning impairment – disorders of neural and emotional balance; communication impairment – hindered verbal contact (speech impediments, autism, stammering); motor impairment – people with motor organ dysfunction. On the basis of that are discussed in this publication the research, we can conclude that the overall assessment of architectural barriers for people with disabilities is as in the case of the Municipal Office in Sosnowiec at an average level. The problems focus mainly on matters of specialized service selected groups of customers with disabilities who require further elaboration. Another type of problem is to issue a limited number of parking spaces for the disabled, but for objective reasons, it will be difficult to solve. Also we can say that the assessment of the architectural barriers by peoples with various types of disability vary significantly. The architectural barriers are the problem especially for people with motor disabilities – those persons are going to municipal office often and because of type of their disability barriers within the office and near the office is the big problem for them. The results are supporting the hypothesis that the type of disability affects perception of architectural barriers by peoples with disabilities.
Caregiver Response to an Online Dementia and Caregiver Wellness Education Platform
Authors: Rodriguez Katie , Fugard Madison , Amini Shawna , Smith Glenn , Marasco Deann , Shatzer Julie , Guerrero Michelle , Garvan Cynthia , Davis Jonathan , Price Catherine
Published: May 2021

Background:

Web-based educational interventions are emerging as a potential solution to improve caregiver dementia knowledge and overall well-being.

Objective:

To assess the feasibility of delivering a web-based intervention for dementia caregivers by examining: 1) engagement with the online platform, 2) skill implementation, and 3) changes on outcome metrics over the 30-day study period.

Methods:

Enrolled participants were onboarded by a trained research coordinator and provided 24/7 access to the platform over 30 days. At study onset and completion, caregivers completed assessments of care recipient dementia severity and neuropsychiatric symptoms along with instruments which measured dementia knowledge, caregiver burden, and carer experience.

Results:

Of 84 referrals, 60 caregivers met study inclusion criteria and 55 completed pre and post study measures. Caregivers completed an average of 8 hours of learning over the 30-day web-based intervention, with 84.4%of participants reporting using at least one skill they learned from the online platform. Eighty-nine percent of participants reported high satisfaction with the web-based educational intervention. There were small effect sizes for decreases in NPIQ neuropsychiatric symptom severity and caregiver distress scores from pre- to post-intervention. Small effect sizes were observed for changes in caregiver burden from pre- to post-intervention among caregivers who perceived their care recipient as having high global deterioration.

Conclusion:

Findings show online educational programs are feasible for informal family caregivers of dementia and have perceived value. Future studies should address caregiver response to online education in less severe versus more severe care recipients, and explore the value of caregiver online platforms in diverse caregiver samples.
Molecular alterations in oral cancer between tobacco chewers and smokers using serum proteomics
Authors: Mohanty Varshasnata , Subbannayya Yashwanth , Patil Shankargouda , Abdulla Riaz , Ganesh Mandakulutur S. , Pal Arnab , Ray Jay Gopal , Sidransky David , Gowda Harsha , Prasad T.S. Keshava , Chatterjee Aditi
Published: May 2021

BACKGROUND: Tobacco exposure (through smoking or chewing) is one of the predominant risk factors associated with the development of oral squamous cell carcinoma (OSCC). Despite the growing number of patients diagnosed with OSCC, there are few circulating biomarkers for identifying individuals at a higher risk of developing the disease. Successful identification of candidate molecular markers for risk assessment could aid in the early detection of oral lesions and potentially be used for community screening of high-risk populations. OBJECTIVE: Identification of differentially expressed proteins in the serum of oral cancer patients which can serve as biomarkers for the diagnosis of the onset of oral cancer among tobacco users. METHODS: We employed a tandem mass tag (TMT)-based quantitative proteomics approach to study alterations in the serum proteomes of OSCC patients based on their tobacco exposure habits (chewing and smoking) compared to healthy individuals with no history of using any form of tobacco or any symptoms of the disease. RESULTS: Mass spectrometry-based analysis resulted in the identification of distinct signatures in the serum of OSCC patients who either chewed or smoked tobacco. Pathway analysis revealed opposing effects of dysregulated proteins enriched in the complement-coagulation signaling cascades with a high expression of the Serpin family of proteins observed in OSCC patients who chewed tobacco compared to healthy individuals whereas these proteins showed decreased levels in OSCC patients who smoked. ELISA-based validation further confirmed our findings revealing higher expression of SERPINA6 and SERPINF1 across serum of OSCC patients who chewed tobacco compared to healthy individuals. CONCLUSIONS : This study serves as a benchmark for the identification of serum-based protein markers that may aid in the identification of high-risk patients who either chew tobacco or smoke tobacco.
Self-Reported Dementia-Related Diagnosis Underestimates the Prevalence of Older Americans Living with Possible Dementia
Authors: McGrath Ryan , Robinson-Lane Sheria G. , Clark Brian C. , Suhr Julie A. , Giordani Bruno J. , Vincent Brenda M.
Published: May 2021

Background: Dementia screening is an important step for appropriate dementia-related referrals to diagnosis and treat possible dementia. Objective: We sought to estimate the prevalence of no reported dementia-related diagnosis in a nationally representative sample of older Americans with a cognitive impairment consistent with dementia (CICD). Methods: The weighted analytical sample included 6,036,224 Americans aged at least 65 years old that were identified as having a CICD without history of stroke, cancers, neurological conditions, or brain damage who participated in at least one-wave of the 2010–2016 Health and Retirement Study. The adapted Telephone Interview of Cognitive Status assessed cognitive functioning. Those with scores≤6 were considered as having a CICD. Healthcare provider dementia-related diagnosis was self-reported. Age, sex, educational achievement, and race and ethnicity were also self-reported. Results: The overall estimated prevalence of no reported dementia-related diagnosis for older Americans with a CICD was 91.4%(95%confidence interval (CI): 87.7%–94.1%). Persons with a CICD who identified as non-Hispanic black had a high prevalence of no reported dementia-related diagnosis (93.3%; CI: 89.8%–95.6%). The estimated prevalence of no reported dementia-related diagnosis was greater in males with a CICD (99.7%; CI: 99.6%–99.8%) than females (90.2%; CI: 85.6%–93.4%). Moreover, the estimated prevalence of no reported dementia-related diagnosis for non-high school graduates with a CICD was 93.5%(CI: 89.3%–96.1%), but 90.9%(CI: 84.7%–94.7%) for those with at least a high school education. Conclusion: Dementia screening should be encouraged during routine geriatric health assessments. Continued research that evaluates the utility of self-reported dementia-related measures is also warranted.
Multidimentional Preoperative Frailty Assessment and Postoperative Complication Risk in Egyptian Geriatric Patients Undergoing Elective Cardiac Surgery
Authors: Tawfik Heba M. , Desouki Rehab R. , Singab Hamdi A. , Hamza Sarah A. , El Said Salma M.S.
Published: May 2021

Background: Frailty affects up to 51%of the geriatric population in developing countries which leads to increased morbidity and mortality. Objective: To determine the association between pre-operative frailty through multidimentional assessment score, and the incidence of post-operative complications and to validate Robinson score in geriatric Egyptian patients undergoing elective cardiac surgery. Methods: We recruited 180 elderly participants aged 60 years old and above, who underwent elective cardiac surgery. They were divided into frail, pre-frail, and non-frail groups after application of Robinson score (which includes cognitive and functional and fall risk assessment, number of comorbidities, and different laboratory data). Type and duration of operations and the presence and severity of complications at days 3 and 7 post-surgery, and the 30-day readmission rate were assessed. Results: Operation duration and the occurrence of postoperative complications at days 3 and 7 were lowest in non-frail and highest in the frail group (p < 0.001 for both). Length of hospital stay and 30-day readmission rate also increased in the frail group. A positive, moderate correlation between frailty and blood transfusion (r = 0.405) and functional dependence (r = 0.552) was found at day-3 post-surgery. Finally, logistic regression analysis identified a 6-fold increase in postoperative complications in the frail group (OR = 6). Conclusion: Preoperative frailty was associated with higher incidence of postoperative complications among geriatric patients undergoing elective cardiac surgery. Frailty assessment by Robinson score can be considered as an accurate tool to predict postoperative complications during preoperative assessment of elderly patients.
Structural Changes in Thalamic Nuclei Across Prodromal and Clinical Alzheimer’s Disease
Authors: Bernstein Adam S. ,   the Alzheimer’s Disease Neuroimaging Initiative, Rapcsak Steven Z. , Hornberger Michael , Saranathan Manojkumar
Published: May 2021

Background: Increasing evidence suggests that thalamic nuclei may atrophy in Alzheimer’s disease (AD). We hypothesized that there will be significant atrophy of limbic thalamic nuclei associated with declining memory and cognition across the AD continuum. Objective: The objective of this work was to characterize volume differences in thalamic nuclei in subjects with early and late mild cognitive impairment (MCI) as well as AD when compared to healthy control (HC) subjects using a novel MRI-based thalamic segmentation technique (THOMAS). Methods: MPRAGE data from the ADNI database were used in this study (n = 540). Healthy control (n = 125), early MCI (n = 212), late MCI (n = 114), and AD subjects (n = 89) were selected, and their MRI data were parcellated to determine the volumes of 11 thalamic nuclei for each subject. Volumes across the different clinical subgroups were compared using ANCOVA. Results: There were significant differences in thalamic nuclei volumes between HC, late MCI, and AD subjects. The anteroventral, mediodorsal, pulvinar, medial geniculate, and centromedian nuclei were significantly smaller in subjects with late MCI and AD when compared to HC subjects. Furthermore, the mediodorsal, pulvinar, and medial geniculate nuclei were significantly smaller in early MCI when compared to HC subjects. Conclusion: This work highlights nucleus specific atrophy within the thalamus in subjects with early and late MCI and AD. This is consistent with the hypothesis that memory and cognitive changes in AD are mediated by damage to a large-scale integrated neural network that extends beyond the medial temporal lobes.
Evaluation of detection capability of eddy current probes with stochastic decision threshold for inspecting pits on austenitic stainless steel welding
Authors: Wang Jing , Song Haicheng , Tomizawa Takuma , Yusa Noritaka , Ling Yuanjin
Published: May 2021

It is still a big challenge to calculate the probability of defect detection for inspecting pits on austenitic stainless steel welding using traditional POD models. Because we determine the decision threshold, the POD curve has a lot of changes as the decision threshold changes, there is no clear reason to insist which threshold is reasonable. This study proposes a new probability of detection (POD) model to quantitatively assess the detection capability of eddy current probes for inspecting pits on austenitic stainless steel welding. The experimental results show that the proposed model is more reasonable than traditional ones. The novel POD model was employed to analyze three eddy current probes, uniform, TR, plus-point probes on austenitic stainless steel welding. The results reveal that the uniform eddy current probe has the best detection capability for inspecting pits on among the three probes.
Prevalence and predictors of adverse outcomes in neonatal seizures
Authors: Famra K. , Batra P. , Aggarwal A. , Banerjee B.D.
Published: May 2021

OBJECTIVES:

Neonatal seizures are significant cause of neonatal mortality and morbidity. Current study was planned to study prevalence of adverse outcomes in neonatal seizures and identify its predictors.

METHODS:

This observational descriptive study was carried out on 220 neonates with seizures. Neonates who succumbed to illness/ death before investigations, or whose maternal records were incomplete were excluded. Blood sugar, serum calcium, serum electrolytes, and USG skull were done in all patients. CT scan, MRI and inborn errors of metabolism profile were done as and when indicated. Adverse outcomes were defined as death, phenobarbitone non responders, or abnormal examination at discharge. Antenatal, perinatal and neonatal predictors of adverse outcomes in neonatal seizures were evaluated.

RESULTS:

Out of 220 neonates with seizures 76(34.5%) had adverse outcomes. Very low birth weight babies (≤1500 gm) [OR 1.27(CI 0.57–2.84)], microcephaly [OR 5.93 (CI 0.55–64.41)], Apgar score≤3 at 5 minutes [OR 11.28(CI 14.18–30.45)], seizure onset within 24 hours [OR 5.99(CI 12.43–14.78)], meningitis [OR 2.63(CI 0.08–6.39)], septicemia [OR1.22(CI 0.45–3.31)] and abnormal cranial USG [OR 7.95(CI 12.61–24.22)] were significant predictors of adverse outcomes in neonates with seizures.

CONCLUSION:

Prematurity, very low birth weight, birth asphyxia, meningitis, septicemia and abnormal USG could predict adverse outcomes in neonatal seizures. Improved antenatal and neonatal clinical practices may help reduce adverse outcomes in these patients.
Navigated perilesional transcranial magnetic stimulation can improve post-stroke visual field defect: A double-blind sham-controlled study
Authors: El Nahas Nevine , Elbokl Ahmed M. , Abd Eldayem Eman Hamid , Roushdy Tamer M. , Amin Randa M. , Helmy Shahinaz M. , Akl Ahmed Zaki , Ashour Aya Ahmed , Samy Shady , Amgad Alaa , Emara Tamer H. , Nowara Mohamed , Kenawy Fatma Fathalla
Published: May 2021

Background:

Visual field defects (VFD) usually do not show improvement beyond 12 weeks from their onset. It has been shown that repetitive presentation of a stimulus to areas of residual vision in cases of visual field defect can improve vision. The counterpart of these areas in the brain are the partially damaged brain regions at the perilesional areas where plasticity can be enhanced.

Objective:

We aimed to study the effect of navigated repetitive transcranial magnetic stimulation (rTMS) applied to perilesional areas on the recovery of patients with cortical VFD.

Methods:

Thirty-two patients with cortical VFD secondary to stroke of more than 3 months duration received 16 sessions of either active or sham high frequency navigated perilesional rTMS. Automated perimetry and visual functioning questionnaire (VFQ-25) were performed at baseline and after completion of the sessions.

Results:

The active group showed significant improvement after intervention, compared to the sham group, in both mean deviation (MD), visual field index (VFI) and in the VFQ-25 scores.

Conclusions:

Navigated rTMS is a new treatment option for post-stroke VFD as it can selectively stimulate areas of residual vision around the infarcted tissue, improving the threshold of visual stimulus detection which could be used alone or in combination with existing therapies.
The COVID-19 Pandemic and nursing challenges: A review of the early literature
Authors: Danesh Mojtaba K. , Garosi Ehsan , Golmohamadpour Hamedeh
Published: May 2021

BACKGROUND: The COVID-19 pandemic has put health systems under unprecedented pressure, challenging their workforce, especially nurses. OBJECTIVE: The current paper presented a review of the early literature concerning emerging nursing challenges during the early stages of the COVID-19 pandemic. METHODS: A systematic search of the published literature between January and May 2020 was carried out in Medline, Science Direct, and Google Scholar to identify relevant quantitative and qualitative studies. RESULTS: Twenty-two original articles were retrieved, the majority of which were survey studies from China. Synthesis of the evidence resulted in four overarching themes including “being physically and mentally drained in the face of fear and uncertainty,” “shortage of personal protective equipment and usability issues,” “psychosomatic disturbances among nurses,” and “moderators to mitigate nurses’ challenges.” CONCLUSIONS: Providing care for demanding COVID-19 patients, nurses experienced a gruelling situation, during which a significant amount of psychological and physical distress was inflicted to them. However, receiving proper support from their organization and society could improve the condition substantially. Further research is required to explore the impact of the COVID-19 pandemic on nurses, especially from Western countries.
The Effect of Pure Garlic (Allium Sativum L.) Juice on The Color Stability of Heat Polymerized Acrylic Resin Denture Base
Authors: Tumara Herlin Nadya , Mourent Miftahullaila  , Sopan Sinamo  , Yohana Aprilia Saragih  , Silvia Giovani
Published: May 2021

Intoduction : PMMA or acrylic resin is a necessary material in dentistry for denture bases, one of which is often used is heat cured acrylic resin or heat polymerized acrylic resin. Garlic juice is a denture cleaner to inhibit bacteria and is also an extrinsic factor that causes discoloration. Purpose: To determine the duration of immersion in pure garlic juice which can cause discoloration of the acrylic resin. Methods: laboratory experiments with posttest only control group design research. Results: The mean ± SD change in color of hot polymerized acrylic resin after immersing in garlic juice for 2, 4, 6, 8 hours was 0.67 ± 0.22; 0.91 ± 0.31; 1.22 ± 0.32; and 1.56 ± 0.25. Conclusion: There is an effect of soaking time with garlic juice on the base of denture acrylic resin on discoloration.
TO STUDY THE DIFFERENT COMPLICATIONS DURING ANTEPARTUM, INTRAPARTUM AND POSTPARTUM PERIODS WITH POSSIBLE MEASURES TO MANAGE TWIN PREGNANCY
Authors: Natu Neeta , Tagde Praneeta
Published: May 2021

Background: The present study of twins was done among the patients admitted in the department of Obstetrics and Gynecology at Sri Aurobindo Medical College and Post Graduate Institute, Indore.

Method: Blood sample from the mother was collected for estimation of hemoglobin percentage to diagnose anemia, ABO & Rh typing for blood transfusion if necessary. Urine examination for albumin, sugar & acetone. Special investigations like USG done whenever possible. In maximum cases ultrasonography was done to detect or confirm presence of twins, their lie, maturity, gestational age, rule out congenital anomaly & to note any IUGR, Discordant growth. Amount of liquor also noted.

Result: 143 (85.10%) babies were LBW. The main factors responsible for LBW were IUGR and prematurity. Intrauterine growth retardation affected 42 cases (24.41%) while prematurity affected 42 cases (24.41%) and 8 (9.3%) cases aborted.

Intrauterine death was more common in first baby, because of malpresentations. Asphyxia was found to be slightly more in second baby in our study. Congenital anomalies were found in total 3 cases (1.78%).  In one case, baby-2 was Anencephalic and in the other case baby-2 had fetal ascites.  In one case baby-1 had multiple congenital anomalies with imperforate anus. Cord prolapse was present in one case. In one case (Case No. 17) first baby was presented by footling with cord prolapse LSCS was done, baby had SBA and died 1 day after birth. There were 8 abortions. All were second trimester abortions (12 weeks and 22 weeks).

Conclusion: In the present study, incidence of various antepartum and intrapartum complications were less in booked cases, which shows that availability of antenatal care to more patients will further reduce their incidence and thus will decrease maternal morbidity.

Keywords: Complications, Antepartum, Intrapartum & Postpartum.
DEMOGRAPHIC PROFILE AND OUTCOMES OF ADVANCED EPITHELIAL OVARIAN CANCER
Authors: Agarwal Ankit , Pandey Arun , Prajapati Giriraj
Published: May 2021

Background: To study the epidemiological features and outcome of epithelial ovarian cancer patients treated at a tertiary care hospital.

Methods: We conducted a retrospective study at our institute to identify patients diagnosed with epithelial Ovarian Carcinoma (EOC) from 2013 to 2018. We studied the epidemiological profile and the outcome of the treatment in terms of response rates, Disease-free survival, and overall survival rates.

Results: A total of 238 patients were diagnosed with EOC over a period of 7 years. Out of 238 patients, complete pretreatment data was available for 197 patients. The median age at diagnosis was 59 years (range: 34–85 years). Totally 39 patients (16.38%) were younger than 45 years of age. The common presenting features were abdominal distension (82%), dysuria (43%), abdominal pain (40%), loss of appetite (36%), constipation (32%), shortness of breath (15%). serum CA125 levels were elevated in 73% cases at presentation

Conclusion: In conclusion, it is of extreme importance to identify the prognostic factors in patients with ovarian cancer to enable us to choose the most appropriate treatment strategy and to identify the risk of progression and death at follow-up. In our study, the patient age and FIGO clinical stage were the only independent prognostic factors reported.

Keywords: FIGO, Ovarian, Germ cell
Self-Efficacy and Self-Regulation as Predictors of Academic Motivation among Undergraduate Students in the United States
Authors:   , Aljuaid Fatimah
Published: May 2021

Problem Some undergraduate students demonstrate lack of academic motivation which negatively affects engagement and perseverance in higher education (Busse & Walter, 2017; Rizkallah & Seitz, 2017; Dresel & Grassinger, 2013). Amotivated students are more likely to drop out of school and disengage from learning activities or underachieve (Wang & Pomerantz, 2009). Although the lack of academic motivation is correlated with deficiency in self-regulation and self-efficacy, relatively little studies have been conducted to examine the impact of these factors on academic motivation particularly in the U.S. This study constructed a hypothesized model to investigate the role of self-regulation and self-efficacy in academic motivation. Method The sample consisted of 349 undergraduate students enrolled in U.S. universities. Participants were recruited via the online-tool QuestionPro. The students completed the Academic Motivation Scale (AMS) and Motivated Strategies for Learning Questionnaire (MSLQ) online providing input about their academic motivation, self-regulation, and self-efficacy. Structural equation modeling was used to evaluate the impact of self-regulation and self-efficacy on academic motivation. Results Analysis of the data indicated that the initial model did not fit the data. The Chi-square value was 271.569, df = 40, p = .000, and poor fit indices were found (GFI = .875, NFI = .874, CFI = .889, RMSEA = .129. SRMR= .090). Therefore, an exploratory analysis was conducted, and modifications made based on modification indices and theory in order to improve the fit indices. The adjusted model showed acceptable fit between the theoretical covariance matrix and the empirical covariance matrix (GFI = .918, NFI = .913, CFI = .928, RMSEA = .108, and SRMR = .072) indicating that the data fit the hypothesized model. The overall adjusted model explained 41% of the variance of academic motivation, in which self-efficacy (β = .45; p < .01) was a better predictor of academic motivation than self-regulation (β = .24; p < .01). There was significant correlation between self-regulation and self-efficacy (r = .69, p < .01) Conclusion Self-regulation and self-efficacy can predict students’ academic motivation. Self-efficacy was the best predictor of academic motivation. Students who reported high beliefs in their capabilities and control over their effort showed high levels of intrinsic motivation. In addition, advanced levels of metacognitive strategies, time and study environment, and effort regulation predict high levels of academic motivation. Further research should be conducted to determine other factors that may contribute to students’ academic motivation. This study offers recommendations for future research and professional practice.
Methylphenidate: A Review
Authors: Oliveira Vinicius Faustino Lima de , Moreira Danilo José Silva , Fonseca Juliana Brito da , Rossi Karoline , Vasconcelos Suzana dos Santos , Dias Claudio Alberto Gellis de Mattos , Oliveira Euzébio de , Dendasck Carla Viana , Araújo Maria Helena Mendonça de , Fecury Amanda Alves
Published: May 2021

Methylphenidate (MFD) is an amphetamine-derived medicine that stimulates the Central Nervous System (CNS), promoting increased attention, less distraction and increased sense of motivation. This study aims to describe the main pharmaceutical characteristics of MFD, highlight the clinical indications for the use of MFD and detail the possible adverse events arising from the consumption of MFD. For this, we conducted a research in the databases ScienceResearch.com, SciELO, LILACS, PubMed and EMBASE and in the institutional repositories of the Federal University of São Paulo, Federal University of Minas Gerais and Federal University of Ceará, using the keywords and associations “methylphenidate”, “ritalin”, “effects” and “effects”. It was evidenced that the drug consists of a racemic mixture formed by four stereoisomers, and the pharmacologically active compound is racemate dextrogyl (d,l)-treo-MFD. It acts on the blockade of dopamine and norepinephrine transporters from the CNS, promoting effects that justify its prescription to treat Attention Deficit Hyperactivity Disorder (ADHD). In recent years, its consumption for non-therapeutic purposes has increased. Some adverse effects of its use have been reported, and insomnia, irritability and headache have been reported.
ПЕРСПЕКТИВИ РОЗВИТКУ ВНУТРІШНЬОГО ТУРИЗМУ В УМОВАХ ПАНДЕМІЇ COVID-19
Authors: Графська Орислава , Підвальна Оксана , Боднарчук Христина
Published: May 2021

Стаття присвячена аналізу тенденцій розвитку туристичної сфери в Україні та світі в умовах пандемії COVID-19, визначенню перспективних напрямів розвитку внутрішнього туризму, зокрема в Україні. Розглянуто вплив пандемії на розвиток туризму у минулому та досліджено стан туристичної сфери у світі та окремих країнах в умовах пандемії COVID-19. Проаналізовано заходи, що вживаються у різних країнах світу, для стимулювання розвитку внутрішнього туризму в умовах пандемії. Вивчено сучасний стан туристичної сфери України в умовах кризи. Виокремлено проблеми, які стримують розвиток внутрішнього туризму в Україні: відсутність системної взаємодії, партнерства між суб’єктами туристичної індустрії; невідповідність якості та ціни послуг; неналежний рівень транспортної доступності та безпечності дестинацій; туристи для подорожей країною найчастіше обирають самодіяльний туризм. Запропоновано три сценарії розвитку внутрішнього туристичного ринку в Україні у 2021 році – оптимістичний, реалістичний та песимістичний. Встановлено, що прогнози розвитку внутрішнього туризму в Україні суттєво залежать також від ситуації з пандемічними обмеженнями у основних країнах-дестинаціях туристичних потоків з України.
ОСОБЛИВОСТІ ФОРМУВАННЯ СИСТЕМИ УПРАВЛІНСЬКОГО ОБЛІКУ НА МАЛИХ ПІДПРИЄМСТВАХ В УКРАЇНІ
Authors: Довжик Олена
Published: May 2021

У статті розглянуто проблему організації та важливість управлінського обліку на малих підприємствах. Досліджено теоретичні засади формування системи управлінського обліку в Україні та проаналізовано міжнародний досвід з цього питання та особливості управлінського обліку малого бізнесу, виділено характеристики практик ведення управлінського обліку на вітчизняних підприємствах та недоліки, до яких вони призводять. Зроблено спробу з'ясування причин проблем в організації управлінського обліку у сфері малого бізнесу. Запропоновано шляхи вдосконалення організації бухгалтерського обліку у відповідності з міжнародним досвідом, розроблено етапи системи управлінського обліку та методика організації бухгалтерського обліку для впровадження на малих підприємствах. Доведено необхідність систематизації та автоматизації управлінського обліку.
Association of Oral Microbiota Properties on Hyaluronidase and Biofilm Formation
Authors: Mohd Zahir Nur Syarafina , Abdul Halim Nabilah Huda , Ahmad Yusof Hanani
Published: May 2021

Correlation between hyaluronidase (Hyl) activity and biofilm detachment in a few bacterial species was found. However, it is unclear if this association applies to bacterial species or for more general bacterial characteristics. This study determined the association between biofilm production and Hyl activity among bacterial isolates from the oral cavity of healthy subjects, and its association with Gram staining group, colony surface morphology and bacteria shape.  The swab was taken from the tongue, cheek and entire teeth surfaces of 35 subjects, and tested for biofilm through modified microtiter plate assay while Hyl production was screened through HA rapid plate method. Forty-four isolates were found, each 50% are Gram-positive, and Gram-negative bacteria, with the majority are cocci and non-mucoid colony. More than 70% of isolates are moderate and strong; (n= 17, 38.6%) and (n=15, 34.1%) respectively for biofilm production; and 68.2% are Hyl producer. A significant association was found between Hyl and bacterial shape (p=0.018) and colony morphology (p=0.018), while other association is not significantly measured, including between Hyl and biofilm (p=0.659). This study showed that biofilm production is not affected by the characteristics of the bacteria to produce or not produce hyaluronidase. Meanwhile, Hyl production is prone in rod shape and mucoid isolates which need further investigations.
Extremal Region Selection for MSER Detection in Food Recognition
Authors: RAZALI MOHD NORHISHAM
Published: May 2021

The visual analysis of foods on social media by using food recognition algorithm provides valuable insight from the health, cultural and marketing. Food recognition offers a means to automatically recognise foods as well the useful information such as calories and nutritional estimation by using image processing and machine learning technique. The interest points in food image can be detected effectively by using Maximally Stable Extremal Region (MSER). As MSER used global segmentation and many food images have a complex background, there are numerous irrelevant interest points are detected. These interest points are considered as noises that lead to computation burden in the overall recognition process. Therefore, this research proposes an Extremal Region Selection (ERS) algorithm to improve MSER detection by reducing the number of irrelevant extremal regions by using unsupervised learning based on the k-means algorithm. The performance of ERS algorithm is evaluated based on the classification performance metrics by using classification rate (CR), error rate (ERT), precision (Prec.) and recall (rec.) as well as the number of extremal regions produced by ERS. UECFOOD-100 and UNICT-FD1200 are the two food datasets used to benchmark the proposed algorithm. The results of this research have found that the ERS algorithm by using optimum parameters and thresholds, be able to reduce the number of extremal regions with sustained classification performance.
Honey Improves Sperm Parameters in High Cholesterol Diet-Fed Male Rabbits
Authors: Mohamed Zenab B. Hamad , Ibrahim Muhammad Bin , Alfarisi Hamad Abdulsalam Hamad , Abdul Wahab Azantee Yazmie , Abd Fuaat Azliana Binti , Che Mohamad Che Anuar
Published: May 2021

Overconsumption of a high-energy diet has a negative impact on sperm motility, morphology, vitality and concentration. Hence, this study aims to investigate the effects of honey on sperm parameters of high cholesterol diet-fed rabbits and compare its effects with atorvastatin. Forty-eight male New Zealand white rabbits were assigned into 6 groups: Control (C): commercial pellet; CH: commercial pellet and 600 mg/kg/day Trihoney; HCD: 1% cholesterol diet; DH1: 1% cholesterol diet and 300 mg/kg/day Trihoney; DH2: 1% cholesterol diet and 600 mg/kg/day Trihoney; DAt: 1% cholesterol diet and 2 mg/kg/day atorvastatin. After 12 weeks, each rabbit was anaesthetized. Sperm were obtained from the cauda of the epididymis. Percentages of progressive (PM) and total motility (TM) were assessed using light microscope. Vitality and morphology were assessed using Eosin-Nigrosin stain. Sperm concentration was calculated using haemocytometer. Administration of 1% cholesterol diet reduced the percentages of PM, TM and normal sperm. Treatment with atorvastatin reduced the percentages of PM, TM, live and normal sperm. A marked reduction in sperm concentration was detected in the HCD and DAt groups. Trihoney groups expressed significantly higher percentages of PM, TM, normal sperm, live sperm and sperm concentration than the HCD and DAt groups. These results indicate that Trihoney has the potential to minimize the negative impacts of a high cholesterol diet on sperm parameters.
STAKEHOLDER RELATIONS AS AN IMPORTANT FACTOR IN THE FUNCTIONING OF CONSTRUCTION ENTERPRISES
Authors: Zubarev D.
Published: May 2021

The necessity of providing stakeholder relations at construction enterprises is proved. Insufficient level of formation and implementation of the strategy of stakeholder relations and attraction of domestic and foreign investors has been identified. This affects the investment attractiveness of construction companies. The purpose of the research on determining the directions and features of the formation of stakeholder relations of construction companies has been achieved. In this context, the following tasks have been solved: identification of stakeholders of construction companies; characteristics of types of stakeholders that interact with construction companies; determination of directions of formation of stakeholder relations of construction enterprises; highlighting the features of the formation of stakeholder relations of construction companies. The normative-legal base concerning formation and realization of stakeholder relations of construction enterprises is characterized.
The directions of formation of stakeholder relations of construction enterprises are determined: informing of information-analytical support on maintenance of stakeholder relations of construction enterprises; identification of factors influencing the formation of stakeholder relations of construction companies; characteristics of indicators that determine stakeholder relations; development of a multilevel system of indicators used to assess the level of efficiency of stakeholder relations of construction companies; assessment of local, generalizing, integral indicators of the level of efficiency of stakeholder relations; construction of a model of the influence of factors on the integrated indicator of the level of efficiency of stakeholder relations of construction enterprises; forecasting changes in the integrated indicator of the level of efficiency of stakeholder relations of construction companies; development of measures to increase the efficiency of stakeholder relations of construction companies; development of scenarios for stakeholder relations in construction companies. Peculiarities of their realization at construction enterprises are singled out.
INTELLECTUAL CAPITAL AS A MODERN TOOL FOR THE FORMATION OF INFORMATION AND ANALYTICAL SUPPORT FOR THE DEVELOPMENT OF CONSTRUCTION ENTERPRISES
Authors: Prunenko D.
Published: May 2021

It is proved that intellectual capital in developed economic systems is one of the main assets that affects the functioning of enterprises. It is established that the topical issue is the definition of intellectual capital as a modern tool for the formation of information and analytical support for the development of construction companies (BP).
The purpose of the research on the definition of intellectual capital as a modern tool for the formation of information and analytical support for the development of construction enterprises has been achieved.
To achieve this goal, the following tasks have been solved: determining the intellectual capital of construction companies; characteristics of the elements of intellectual capital of construction companies; formation of tools for the formation of information and analytical support for the management of intellectual capital of construction companies.
It is determined that the intellectual capital of construction companies is a category that has a complex structure and is characterized by a set of functional, cost, urban, spatial and features, which as a result of constant transformations form the relevant knowledge, skills, experience of workers to create an intelligent product. attractiveness, competitiveness and efficiency of activities based on interaction between customers, investors, contractors, public authorities and BP. Elements of construction capital are defined. The tools of formation of information-analytical support of development of construction enterprises are singled out.
TRANSFER PRICES: PREREQUISITES FOR USE IN MANAGEMENT ACCOUNTING AND TAX ADMINISTRATION
Authors: Vlasova O.
Published: May 2021

Today, the issues of transfer pricing come to the fore in the ranking of current problems of tax administration not only in Ukraine but also in the world as a whole. This is due to the need for tax control to ensure price equality between related and independent entities in international business as a measure to combat the erosion of the tax base and the withdrawal of profits from taxation. The article presents a structured analysis of research by foreign and domestic scientists on transfer pricing in the field of management accounting or tax control. In particular, the grouping of views of scientists and practitioners on the nature and role in the accounting and analytical system of transfer pricing from the point of view of management accounting and tax administration. Study of the impact on the practice of transfer pricing methods of the picture of economic reality distorted by the negative impact of the COVID-19 pandemic. The need to use the transfer pricing mechanism in management accounting is due to the current trend of decentralization of management, and a prerequisite - the desire of top management to accelerate the production process, accelerate the turnover of equity and maximize profits. The advantages of using transfer pricing in management accounting to accelerate the production process and maximize profits, which led to the creation of corporations with the final technological cycle. It is also established that when deciding on the use of such a tool of internal pricing, one should keep in mind the cautions analyzed in the article. The preconditions for the introduction of tax control over transfer pricing in international business, as well as the basic laws and regulations in force in the global and Ukrainian economic space. The necessity and validity of the application of the OECD International Guidelines on Transfer Pricing, despite the provisions of Art. 39 of the Tax Code of Ukraine The ways of further development of tax control over transfer pricing within the framework of the BEPS Action Plan in Ukraine are considered. The need for further research on solving the problems of transfer pricing in the field of management accounting and taxation was identified, especially on the preparation of an information basis to justify the compliance of transfer prices with «Arm’s length principle».
Comparison of Enzymatic and Acidic Fractionation of Corn Fiber for Glucose-rich Hydrolysate and Bioethanol Production by Candida boidinii
Authors: Fehér Anikó , Bedő Soma , Fehér Csaba
Published: May 2021

Corn fiber is a by-product of the corn wet milling process and a promising raw material to produce bioethanol in a bio-refinery process. In this study, enzymatic and acidic fractionations of corn fiber were compared with particular attention to produce glucose-rich hydrolyzates. The acidic fractionation contained two, sequential, sulphuric acid-catalyzed, hydrolysis steps based on our previous study. In the enzymatic fractionation process, corn fiber was pre-treated by soaking in aqueous ammonia (18.5 % (w/w) dry matter, 15 % (w/w) ammonia solution, 24 hours) and then hydrolyzed by using Hemicellulase (NS 22002) enzyme cocktail. The cellulose part of the solid residues obtained after the acidic and enzymatic fractionation processes was enzymatically hydrolyzed by using Cellic Ctec2 and Novozymes 188 (12.5 % (w/w) dry matter, 50 °C, 72 hours). Cellulose hydrolysis after the acidic and enzymatic fractionation resulted in a supernatant containing 64 g/L and 25 g/L glucose, respectively. Therefore, ethanol fermentation experiments were performed in Separated Hydrolysis and Fermentation (SHF) and Simultaneous Saccharification and Fermentation (SSF) configurations after the acidic fractionation of corn fiber. SHF configuration was found to be more advantageous regarding the achievable ethanol yield. Although the fermentation with Candida boidinii NCAIM Y.01308 was accomplished within longer time (43 hours) compared to Saccharomyces cerevisiae (5 hours), the achieved ethanol yields were similar (79%) during the SHF process. It was concluded that acidic fractionation is more efficient to produce glucose-rich hydrolyzate from corn fiber compared to enzymatic fractionation, and Candida boidinii is suitable for ethanol fermentation on the glucose-rich hydrolyzate.
Media Pembelajaran Rumah Adat Indonesia Berbasis Android Menggunakan Algoritma Fisher Yates Shuffle
Authors:   Sekolah Tinggi Teknologi Garut, Sidik Marwah Maulana , Maylawati Dian Sa'adillah , Setiawan Ridwan
Published: May 2021

Indonesia merupakan negara kepulauan yang memiliki berbagai suku bangsa, adat, maupun budaya, seiring dengan berjalannya waktu, dan adanya unsur-unsur budaya baru yang masuk ke Indonesia dapat menimbulkan perubahan yang sangat besar, sehingga minat dalam belajar mengenai budaya Indonesia sangatlah kurang, sedikit demi sedikit masyarak Indonesia melupakan budaya nya. Salah satu dari budaya tersebut yaitu rumah adat yang semakin ditinggalkan dan diganti dengan unsur-unsur moderen. media pembelajaran yang menarik dengan memanfaatkan teknologi sekarang yang salah satunya yaitu android, sebagai sarana untuk mempermudah dalam pemelajar. Penelitian ini bertujuan untuk membangun media pembelajaran berbasis android untuk mempermudah dalam pembelajaran mengenai rumah adat, agar dapat menarik minat belajar masyarakat Indonesia khususnya anak-anak yang dalam fase belajar. Aplikasi ini dibangun dengan menggunakan metodologi Multimedia Development Life Cycle versi Luther Sutopo dengan tahapan concept , design, material collecting, assembly, testing dan distribution. Selain itu, juga menggunakan algoritma Fisher Yates Shufle sebagai algoritma untuk pengacakan agar media pembelajaran lebih interaktif dan membantu dalam mengukur tingkat pemahaman pada peroses pembelajaran. Pengujian yang dilakukan menggunakan pengujian alpha test dan beta test dengan jenis pengujian black box dan white box. Adapun hasil dari aplikasi yang telah dievaluasi melalui kuesioner dengan jumlah 20 responden, aplikasi ini sangat membantu, mudah dipelajari dan dipahami, begitu pula perandoman yang dilakukan menggunakan Algoritma fisher yates shuffle depat berjalan dengan sangat baik, pada perhitungan pengujian setiap langkah-langkah dalam melakukan peroses pengacakan bernilai sama.