bluuebunny/crossref_metadata_2025 huggingface dataset:
NewN-(2-phenyl-4-oxo-1,3-thiazolidin-3-yl)-1,2-benzothiazole-3-carboxamides and acetamides as antimicrobial agents
Authors: Incerti Matteo , Vicini Paola , Geronikaki Athina , Eleftheriou Phaedra , Tsagkadouras Athanasios , Zoumpoulakis Panagiotis , Fotakis Charalmpos , Ćirić Ana , Glamočlija Jasmina , Soković Marina
Published: November 2017

21 novelN-(2-phenyl-4-oxo-1,3-thiazolidin-3-yl)-1,2-benzothiazole-3-carboxamides and acetamides have been synthesized and evaluated for their antimicrobial activity.
Phenylethynyl-substituted heterocycles inhibit cyclin D1 and induce the expression of cyclin-dependent kinase inhibitor p21Wif1/Cip1in colorectal cancer cells
Authors: Sviripa Vitaliy M. , Kril Liliia M. , Zhang Wen , Xie Yanqi , Wyrebek Przemyslaw , Ponomareva Larissa , Liu Xifu , Yuan Yaxia , Zhan Chang-Guo , Watt David S. , Liu Chunming
Published: November 2017

Fluorinated phenylethynyl-substituted heterocycles inhibit cyclin D1, induce cyclin-dependent kinase inhibitor-1 and block the proliferation of colorectal cancer cells.
Interaction of serum albumins with fluorescent ligand 4-azido coumarin: spectroscopic analysis and molecular docking studies
Authors: Paul Sandip , Sepay Nasim , Sarkar Shrabana , Roy Pritam , Dasgupta Swagata , Saha Sardar Pinki , Majhi Anjoy
Published: November 2017

The investigation of the binding of 4-AC to biomolecular systems using photophysical techniques and molecular docking studies.
Synthesis process, size and composition effects of spherical Fe3O4 and FeO@Fe3O4 core/shell nanoparticles
Authors: Tancredi Pablo , Rojas Patricia C. Rivas , Moscoso-Londoño Oscar , Wolff Ulrike , Neu Volker , Damm Christine , Rellinghaus Bernd , Knobel Marcelo , Socolovsky Leandro M.
Published: November 2017

In this work, we study the link between synthesis conditions, crystalline structure and magnetic properties of exchange-coupled and single domain iron oxide nanoparticles
Light driven epoxidation of olefins using a graphene oxide/g-C3N4 supported Mo (salen) complex
Authors: Bian Gang , Jiang Pingping , Wang Fang , Shen Yirui , Jiang Kelei , Liu Lin , Zhang Weijie
Published: November 2017

A novel Schiff (Mo) base complex supported on GO/g-C3N4 was prepared and applied to the photocatalytic epoxidation reactions.
Healable terpyridine-based supramolecular gels and the luminescent properties of the rare earth metal complex
Authors: Yang Hewei , Wang An , Zhang Limin , Zhou Xinyu , Yang Guang , Li Yanjie , Zhang Yuzhe , Zhang Bao , Song Jian , Feng Yaqing
Published: November 2017

The self-assembly pattern of terpyridine-based gelator C6S is proposed and the multicolor luminescent metallogel C6S–Eu/Tb investigated.
Free standing growth of MnCo2O4 nanoflakes as an electrocatalyst for methanol electro-oxidation
Authors: Jadhav Harsharaj S. , Roy Animesh , Chung Wook-Jin , Seo Jeong Gil
Published: November 2017

A binder and carbon-free electrodeposited MnCo2O4/NF electrode displays superior electrochemical performance and stability for the application of methanol oxidation.
A facile synthesis of size- and shape-controlled Gd(OH)3 nanoparticles and Gd(OH)3@Au core/shell nanostars
Authors: Li Jingchao , Cai Hongdong , Dong Shunyao , Zhang Tianxiong , Peng Chen , Shi Xiangyang , Shen Mingwu
Published: November 2017

A facile hydrothermal route was developed to generate size- and shape-controlled (Gd(OH)3) nanoparticles and polyethylenimine-stabilized Gd(OH)3@Au core/shell nanostars with photothermal properties.
Large magneto-optical effects in hole-doped blue phosphorene and gray arsenene
Authors: Zhou Xiaodong , Feng Wanxiang , Li Fei , Yao Yugui
Published: November 2017

Blue phosphorene (BP) and gray arsenene (GA), consisting of phosphorus and arsenic atoms in two-dimensional (2D) low-buckled honeycomb lattices, respectively, have received great interest because of their excellent electronic and optoelectronic performances.
Defects by design: synthesis of palladium nanoparticles with extended twin defects and corrugated surfaces
Authors: King Melissa E. , Personick Michelle L.
Published: November 2017

Corrugated palladium nanoparticles with controlled, defect-rich surfaces are synthesized through a combination of surface passivation directed growth and oxidative etching.
Facile solvothermal approach to pristine tetrahedrite nanostructures with unique multiply-voided morphology
Authors: Regulacio Michelle D. , Tee Si Yin , Lim Suo Hon , Teng Choon Peng , Koh Leng-Duei , Liu Shuhua , Han Ming-Yong
Published: November 2017

Solvothermally-prepared tetrahedrite (Cu12Sb4S13) nanostructures with unique multiply-voided architecture were found to form via an oriented attachment growth process.
The effect of pendant group structure on the thermoresponsive properties of N-substituted polyesters
Authors: Swanson John P. , Cruz Megan A. , Monteleone Leanna R. , Martinez Michael R. , Costanzo Philip J. , Joy Abraham
Published: November 2017

Structure–property correlation studies of a diverse set of biodegradable thermoresponsive polyesters provides a rationale for the design of thermoresponsive polyesters with desired cloud points.
Co-delivery of doxorubicin and methotrexate by dendritic chitosan-g-mPEG as a magnetic nanocarrier for multi-drug delivery in combination chemotherapy
Authors: Rahimi Mahdi , Safa Kazem D. , Salehi Roya
Published: November 2017

Nanoparticulate drug delivery systems have the potential to improve the therapeutic efficacy of anticancer agents, and combination therapy is a promising strategy for clinical cancer treatment with synergistic effects.
Study of structural, optical and magnetic properties of cobalt doped ZnO nanorods
Authors: Chanda Anupama , Gupta Shipra , Vasundhara M. , Joshi Shalik R. , Mutta Geeta R. , Singh Jai
Published: November 2017

Cobalt doped zinc oxide nanoparticles (NPs) and nanorods (NRs) were synthesized by a simple chemical method.
Alkylmethylimidazolium tricyanomethanide based supported ion gel membranes for CO2 separation
Authors: Hwang Yongha , Cho Eunhae , Jung Jiyoon , Kang Yong Soo , Won Jongok
Published: November 2017

Supported ion gel membranes with good mechanical stability for CO2 separation were prepared using triblock copolymers in an ionic liquid.
Transformable protein–gold hybrid materials serve as supramolecular vehicles for gene delivery
Authors: Li Zhenhua , Ding Han , Yan Fei , Li Hongwei , Chen Zhijun
Published: November 2017

PGHN–DNA can be a good model to study DNA–carrier interaction as well as a new carrier for gene delivery research.
Influence of interfering anions on Cu2+ and Zn2+ ions removal on chestnut outer shell-derived hydrochars in aqueous solution
Authors: Hong Xiaoting , Fang Chengran , Hui K. S. , Hui K. N. , Zhuang Haifeng , Liu Wanpeng , Shan Shengdao
Published: November 2017

Hydrothermal carbonization method was used to produce different hydrochars from chestnut outer shell at various temperatures while resolving the environmental issues of agricultural bio-waste.
Direct cryopreservation of adherent cells on an elastic nanofiber sheet featuring a low glass-transition temperature
Authors: Batnyam Onon , Suye Shin-ichiro , Fujita Satoshi
Published: November 2017

Electrospun nanofibers, featured a lower glass-transition temperature than the freezing temperature and a loose mesh structure, allows the direct cryopreservation of adherent cells towards the investigation of cell-material composites.
Characterization of an archaeal photoreceptor/transducer complex from Natronomonas pharaonis assembled within styrene–maleic acid lipid particles
Authors: Voskoboynikova N. , Mosslehy W. , Colbasevici A. , Ismagulova T. T. , Bagrov D. V. , Akovantseva A. A. , Timashev P. S. , Mulkidjanian A. Y. , Bagratashvili V. N. , Shaitan K. V. , Kirpichnikov M. P. , Steinhoff H.-J.
Published: November 2017

The archaeal receptor/transducer complex NpSRII/NpHtrII retains its integrity upon reconstitution in styrene–maleic acid lipid particles.
Sawdust as an effective biotemplate for the synthesis of Ce0.8Zr0.2O2and CuO–Ce0.8Zr0.2O2catalysts for total CO oxidation
Authors: Kaplin Igor Yu. , Lokteva Ekaterina S. , Golubina Elena V. , Maslakov Konstantin I. , Strokova Natalia E. , Chernyak Sergei A. , Lunin Valery V.
Published: November 2017

The high catalytic efficiency of biomorphic systems can be explained by the unique texture and effect of ash impurities (K, Ca).
Deformylation reaction-based probe forin vivoimaging of HOCl
Authors: Wei Peng , Yuan Wei , Xue Fengfeng , Zhou Wei , Li Ruohan , Zhang Datong , Yi Tao
Published: November 2017

We report a near-infrared emissive probe which can detect HOClin vivoby both fluorescence imaging and the naked eye.
Ligand effect on the catalytic activity of porphyrin-protected gold clusters in the electrochemical hydrogen evolution reaction
Authors: Eguchi Daichi , Sakamoto Masanori , Teranishi Toshiharu
Published: November 2017

Ligand effect on the catalytic activity of gold clusters in the electrochemical hydrogen evolution reaction.
Driving dynamic colloidal assembly using eccentric self-propelled colloids
Authors: Ma Zhan , Lei Qun-li , Ni Ran
Published: November 2017

Designing protocols to dynamically direct the self-assembly of colloidal particles has become an important direction in soft matter physics because of promising applications in the fabrication of dynamic responsive functional materials.
Modifying the electrochemical performance of vertically-oriented few-layered graphene through rotary plasma processing
Authors: Lin Jinghuang , Jia Henan , Cai Yifei , Chen Shulin , Liang Haoyan , Wang Xu , Zhang Fu , Qi Junlei , Cao Jian , Feng Jicai , Fei Wei-dong
Published: November 2017

We strategically created defects on the side surfaces of VFG via defect engineering using rotary plasma etching, which not only improves the wettability with electrolyte, but also provides more electroactive sites.
From the functionalization of polyelectrolytes to the development of a versatile approach to the synthesis of polyelectrolyte multilayer films with enhanced stability
Authors: Nguyen Thi-Thanh-Tam , Belbekhouche Sabrina , Dubot Pierre , Carbonnier Benjamin , Grande Daniel
Published: November 2017

A novel approach to the synthesis of polyelectrolyte multilayer films with enhanced stability.
Integrated 3D self-supported Ni decorated MoO2 nanowires as highly efficient electrocatalysts for ultra-highly stable and large-current-density hydrogen evolution
Authors: Ren Bowen , Li Dongqi , Jin Qiuyan , Cui Hao , Wang Chengxin
Published: November 2017

Ni decorated MoO2 nanowires gives platinum-like HER activity and unprecedented stability over 320 hours even in the order of 1000 mA cm−2 in alkaline solution.
Photoinduced degradation from trace 1,8-diiodooctane in organic photovoltaics
Authors: Jacobs Ian E. , Wang Faustine , Bedolla Valdez Zaira I. , Ayala Oviedo Alejandra N. , Bilsky David J. , Moulé Adam J.
Published: November 2017

Residual 1,8-Diiodooctane (DIO), a common solvent additive used in organic photovoltaic (OPV) films, is found to cause photodegradation even at ppm concentrations.
The relationship between systemic iron homeostasis and erythropoiesis
Authors: Rishi Gautam , Subramaniam V. Nathan
Published: November 2017

Red blood cell production (erythropoiesis) is the single largest consumer of iron in the body; this need is satisfied by maintaining a sensitive regulation of iron levels. The level of erythropoietic demand regulates the expression of the iron hormone hepcidin and thus iron absorption. Erythropoiesis-mediated regulation of hepcidin is an area of increasing importance and recent studies have identified a number of potential regulatory proteins. This review summarizes our current knowledge about these candidate erythroid regulators of hepcidin and the relation between transferrin receptors and erythropoiesis.
Bias non‐conservation characteristics of drain current noise of 40 nm n‐MOSFETs in high‐frequency band
Authors: Wang Jun
Published: November 2017

The behaviours of drain current noise of 40 nm n‐MOSFETs are distinguished by comparing with 120 nm n‐MOSFETs over an extended range of bias voltages and temperature. The measurement results strongly indicate that the high‐frequency noise mechanism of 40 nm n‐MOSFETs is changed from suppressed shot noise to thermal noise on conditions of low‐voltage weak interaction.
Five to 25 Gb/s continuous time linear equaliser with transversal architecture
Authors: Zhang H. , Monaco E. , Bassi M. , Mazzanti A.
Published: November 2017

Transceivers for backplane serial links operating up to 25 Gb/s demand flexible equalisers with high accuracy in matching the channel response. A continuous time linear equaliser (CTLE) with a transversal architecture features variable DC gain and two zeros that can be tuned independently. The transversal architecture yields a paraboloid mean‐square‐error surface, allowing optimal adaptation through gradient descent algorithms. The CTLE was realised in a 28 nm CMOS technology and measurements are presented at data rate from 5 to 25 Gb/s across 20 dB‐loss channels. Core power dissipation is 17 mW from 1 V supply and horizontal eye opening at BER 10−12 is equal or larger than 50%, comparing favourably against previously reported equalisers targeting similar data‐rate and channel loss.
First demonstration of commodity L2 switch‐based passive optical network
Authors: Nishimoto K. , Yamada T. , Kani J. , Otaka A.
Published: November 2017

The ‘commoditisation’ (i.e. using commodity hardware or commodity device as a hardware platform for network equipment) and ‘softwarisation’ (i.e. implementing the network function of the target equipment by software) have recently become big trends among communication carriers struggling to balance cost‐efficiency and service flexibility. Especially in optical access networks, the concept of the commodity layer 2 (L2) switch‐based passive optical network (PON) is attracting attention, but performance demonstrations have not been reported. This Letter offers the first performance demonstration of the L2 switch‐based gigabit ethernet PON prototype constructed with an L2 switch and software‐based PON‐specific functions. The prototype achieves nearly 1 Gbps throughput in one‐way transmission. Moreover, an additional numerical analysis confirms that the authors proposed architecture can accommodate sufficient PON port number.
Joint opportunistic user scheduling and power allocation: throughput optimisation and fair resource sharing
Authors: Ge Xin , Jin Hu , C. M. Leung Victor
Published: November 2017

Despite extensive studies on optimal power allocation, how to design an efficient joint user scheduling and power allocation scheme for uplink multiuser networks remains largely unexplored. This study investigates joint opportunistic user scheduling and power allocation in uplink multiuser networks to maximise user throughput subject to the power and resource sharing constraints. By exploiting the cumulative distribution function‐based scheduling method, the authors first characterise the optimal power allocation subject to both long‐term and short‐term power constraints. Instead of calculating the transmit power in an iterative and central manner, users can independently decide their instantaneous transmit power in the proposed scheme, which facilitates the algorithm implementation for each user in uplink networks. The closed‐form throughput of the proposed scheme is also derived, which can provide an efficient way to estimate and evaluate user performance. Numerical results reveal that compared with several benchmark schemes, the proposed scheme improves throughput performance significantly.
Spatial characteristics of the massive MIMO channel based on indoor measurement at 1.4725 GHz
Authors: Lu Yanping , Tao Cheng , Liu Liu , Liu Kai
Published: November 2017

Massive multiple‐input–multiple‐output (MIMO) is acknowledged as a key technology for the fifth generation of wireless communication systems, theoretically proved to be of higher throughput, better robustness, superior spectrum‐ and energy‐efficiency with a general presumption that the channels tend to pairwise orthogonal with the increasing of the asymmetrical antenna pairs. Recently, more and more researches have cast light on massive MIMO system modelling. However, few investigations have been done on spatial characteristics of massive MIMO systems, especially the systems equipped with more than 100 antennas. This study focuses on the massive MIMO channel spatial characteristics based on indoor line‐of‐sight radio propagation measurement at 1.4725 GHz, and extracts spatial parameters such as angle of arrival, angle of departure and power azimuth spectrum from experimental data. The angles of departure (AODs) show a linear decrease along the linear antenna array, which are in agreement with the simulation of the ray tracing. On the basis of the realistic results of angular spread and the Gaussian density model, the investigation proves that antenna elements are deeply correlated and the envelope correlation coefficients show negative exponential down‐trend with the increasing of antenna spacing in massive MIMO systems.
Power line communications under Rayleigh fading and Nakagami noise: novel insights on the MIMO and multi‐hop techniques
Authors: Abou‐Rjeily Chadi
Published: November 2017

This work targets a comprehensive understanding of the impact of the serial‐relaying and multiple‐input‐multiple‐output (MIMO) fading mitigation techniques on the performance of indoor power line communication (PLC) systems. While these techniques were studied extensively under additive Gaussian noise, we aim at highlighting the implications of Nakagami‐like noise on the achievable performance levels. The author derive approximate closed‐form expressions for the bit error rate (BER) under Rayleigh fading and Nakagami‐m background noise where the obtained approximations are very close to the exact BERs. The derived expressions are useful for evaluating the achievable diversity orders and for relating the BER to the main parameters of the PLC system in a direct and intuitive way. In this context, we analytically prove that MIMO doubles the diversity order with different combining schemes while the diversity order of a system under Nakagami‐like noise is only half the diversity order that would have been obtained under Gaussian noise. The author also shows that multi‐hop relaying does not enhance the diversity order.
Low‐loss BiCMOS spoof surface plasmon polariton transmission line in sub‐THz regime
Authors: Qi Zihang , Li Xiuping , Zhu Hua
Published: November 2017

This study presents an on‐chip spoof surface plasmonic polariton transmission line (sSPP‐TL) in the sub‐THz regime. The proposed sSPP‐TL is designed and fabricated in the standard BiCMOS process. To eliminate the influence of a high index silicon substrate, a special underlying ground shielding plane is introduced. A mode converter is designed with both impedance and momentum matching in order to achieve efficient conversion from grounded coplanar waveguide to sSPP‐TL. Electromagnetic (EM) simulated and measured results show good conversion efficiency from quasi‐transverse EM to sSPP mode (measured input reflection coefficient is below −18.5 dB). More importantly, a low propagation loss profile (average measured insertion loss is 1.54 dB/mm) is observed in the broadband frequency range in sub‐THz (140–325 GHz). The demonstrated sSPP‐TL has shown great potential for on‐chip sub‐THz communication in the standard silicon process.
Research and verification for an improved two‐way parabolic equation method in obstacle environment
Authors: Wei Qiao‐Fei , Yin Cheng‐You , Wu Wei
Published: November 2017

An improved two‐way parabolic equation (2WPE) method for predicting radio wave propagation in obstacle environment is proposed. Classical 2WPE is mainly utilised for calculating radio propagation under irregular terrain by taking the undulating ground and obstacles as a whole, which yields calculation precision is very limited by the terrain inclination. In order to address the above problems, according to the principle of domain decomposition, by dividing the obstacles and the ground into different zones, 2WPE can be improved to calculate the fields in obstacle environment. With the improved 2WPE, the real phases of both the forward and backward waves can be retrieved when a radio wave entering and leaving the obstacles, and the total field can be obtained by superposition of forward and backward waves. After that, method of moments (MoM) is applied to verify the accuracy of the improved 2WPE in the short distance. In the simulation, the equivalent source model is used to unify the initial field or source settings of 2WPE and MoM to improve the verification precision. The accuracy and superiority of the improved 2WPE are proved, which lays a foundation for the analysis of radio wave propagation in the more complex environment.
Ninja array antenna: novel approach for low backscattering phased array antenna
Authors: Konno Keisuke , Yuan Qiaowei , Chen Qiang
Published: November 2017

This study presents a novel concept of a low backscattering phased array antenna, a Ninja array antenna. One of the advantages of the Ninja array antenna over the conventional phased array antenna is low backscattering performance over its operating frequency band, which is not available using a conventional phased array antenna with a band‐pass radome. The Ninja array antenna is designed in the same manner as the design of reflectarrays, so that the main lobe of its scattering field is directed to a specific direction except for backscattering one. As a result, its backscattering is reduced in comparison with that of the conventional phased array antenna. Although the Ninja array antenna is composed of non‐identical array elements such as the reflectarray, it works as a phased array antenna because desired amplitude and phase of excitation can be obtained numerically via an array element pattern. Numerical simulation is performed and the scattering/radiation performance of the Ninja array antenna is demonstrated.
Ultra‐compact highly selective quasi‐elliptic filters based on combining dual‐mode SIW and coplanar waveguides in a single cavity
Authors: Liu Qing , Zhou Dongfang , Lv Dalong , Zhang Dewei , Zhang Yi
Published: November 2017

Two bandpass filters (BPFs) are implemented on a single dual‐mode square‐shaped substrate‐integrated waveguide (SIW) cavity with two etched coplanar waveguides. The proposed BPFs can achieve two transmission zeros (TZs) using dual modes in the SIW cavity (i.e. TE102 and TE201) with non‐resonating mode (i.e. fundamental TE101), which provides a direct input‐to‐output coupling. Moreover, the positions of the two TZs can be tuned by changing the positions of input and output ports. Moreover, an extra TZ with controllable position is also achieved by using controllable electric and magnetic mixed coupling; and the TZ also can be split into two TZs for the mixed cross‐coupling paths. The BPFs with the controllable TZs improve the selectivity and out‐of‐band rejection. The designed BPFs have a centre frequency of 5.8 GHz. The measured results agree with the simulated ones.
Reconfigurable OAM antenna based on sub‐wavelength phase modulation structure
Authors: Wang Xinyue , Chen Yiling , Zheng Shilie , Zhang Xianmin
Published: November 2017

A reconfigurable orbital angular momentum (OAM) antenna is studied based on PIN diode loaded multi‐layer phase modulation structure. The PIN diodes on each layer are controlled on and off by changing their bias voltages, thus the phase range of the multi‐layer antenna unit can cover 0–2π. Considering the phase superposition of the OAM carrying beam and lens's beam converging, different OAM generation together with beam focusing can be designed by tuning the number of conductive PIN diodes of each layer. The reconfigurable OAM antenna with modes of ±1, ± 2, ±3 and ±4 is investigated via theoretical analysis as well as software simulation. The simulation results show that a single OAM state can be generated at a given time and eight OAM beams are switchable at 10 GHz by changing the bias voltage of each diode. The authors’ work may give a new sight for the reconfigurable OAM antenna design and will widen the applications of the OAM‐based electromagnetic sensing.
Volume integral equation equivalence principle algorithm domain decomposition with body of revolution equivalence surface
Authors: Li Mengmeng , Zhuang Tao , Chen Rushan
Published: November 2017

A novel equivalence principle algorithm (EPA) domain decomposition method previously for the surface integral equation is explored for volume integral equation in this work. The whole object is decomposed into several subdomains, the equivalence spheres are automatically produced to enclose each subdomain. The Rao–Wilton–Glisson (RWG) and body of revolution (BoR) basis functions are defined on the equivalence sphere surface. The equivalence currents defined on the RWG basis functions are evaluated with multilevel fast multipole algorithm, and then the currents defined on the RWGs can be projected onto the BoR basis functions. Compared with surface integral equation EPA‐BoR algorithm, the ratio of the number of average original unknowns in each subdomain with respect to the equivalence unknowns is relatively larger, which leads to significant reduction of computations. Numerical simulations validate the accuracy and efficiency of the proposed method.
Ultra‐wideband directive antenna based on an inclined cone body
Authors: Lopez‐Arzate Elizabeth , Tirado‐Mendez Jose Alfredo , Caltenco‐Franca Jose , Flores‐Leal Ruben , Jardon‐Aguilar Hildeberto , Peyrot‐Solis Marco Antonio
Published: November 2017

In this study, a transversal cut of a revolution surface body is inspired to obtain a planarised ultra‐wideband antenna. The revolution surface body is based on an inclined conical form to obtain a directive radiation pattern and a triangular reflector to increase the directivity. Once the optimal inclined angle is obtained, the three‐dimensional body is segmented obtaining a triangular cut, and the planarised radiator is optimised in order to improve the matching over the required bandwidth. To achieve so, the edges of the radiator are convex‐shaped and the resulting antenna performs from 2.8 to 13.1 GHz, for an S11 parameter below −10 dB. The antenna has a directive radiation pattern and an average gain of 7 dB over the entire bandwidth.
Low‐profile patch antennas with enhanced horizontal omnidirectional gain for DSRC applications
Authors: Liu Ankang , Lu Yilong , Huang Ling
Published: November 2017

Here, a low‐profile microstrip patch antenna with vertical polarisation and over 3 dB enhanced gain in the horizontal plane is proposed for dedicated short‐range communications (DSRC) application. It is a centre‐fed circular patch antenna coupled by an annular ring and shorted concentrically with a set of shorting vias. For further increasing the gain in the horizontal plane, six groups of microstrip patches with one edge open and three edges shorted, which work as magnetic dipole antennas, are laid around the shorted circular patch‐ring antenna (SCPRA). These gain enhancement elements resonate at 5.9 GHz and guide the TM wave along the horizontal surface. In addition, an equivalent circuit model of SCPRA is presented as a tool for easier impedance matching. The number of gain enhancement elements in each group can be adjusted to achieve variable radiation patterns in the horizontal plane. Two antennas achieving omnidirectional and quasi‐elliptical radiation patterns are proposed, simulated, and measured. The measured results agree well with the simulated results, and the quasi‐elliptical radiation patterns in the horizontal plane of the antenna demonstrate the desirable performance for DSRC applications.
Preparation of superamphiphobic aluminium alloy surface based on laser‐EDM method
Authors: Wan Yanling , Xi Chuanwen , Liu Zhigang , Yu Huadong , Li Jing
Published: November 2017

In order to achieve superamphiphobic surface of aluminium alloy, a method based on laser‐EDM (electrical discharge machining) was proposed. By means of laser etching, the size of the controllable micrometre square column structure could be prepared on the surface of aluminium alloy. Then combined with the electric processing method, the binary micro‐nano rough structure was constructed and modified with fluorosilane methanol solution, and the superamphiphobic surface was achieved successfully. The morphology and size of the superamphiphobic surface were observed by scanning electron microscopy and laser confocal microscopy, and the superamphiphobic performance of the surface was detected by video optical contact angle. The results showed that the water contact angle of the surface prepared by laser‐EDM was 157.06°. After the modification of fluorosilane methanol solution, the contact angle of the surface to ethylene glycol reached 156.46°. It can be discovered that the acquisition of binary micro‐nano rough structure and the decrease of surface energy are important conditions to obtain superamphiphobicity. Compared with the existing methods, laser etching can be a good control surface morphology, and eventually get superamphiphobic surface.
Fabrication of high‐density microneedle masters towards the commercialisation of dissolving microneedles
Authors: Chiaranairungroj Muthita , Pimpin Alongkorn , Srituravanich Werayut
Published: November 2017

Recent progress of dissolving microneedles opens up a great potential for the utilisation of microneedles in a wide range of applications. However, the commercialisation of dissolving microneedles requires mass production of microneedle masters and moulds. In this work, a simple, low‐cost and high‐throughput fabrication method of high‐density microneedle masters is presented. The high‐density microneedle masters were fabricated by first machining an aluminium workpiece to form high‐density rectangular column arrays using wire‐cut electrode discharge machining. Subsequently, the rectangular column arrays were subjected to a chemical etching under a mass‐transport limited condition resulting in the formation of conical‐shaped microneedle masters without the need of etch mask. For demonstration, the fabricated microneedle masters were used as a template for the fabrication of an inverse polymer mould and subsequently the polymer mould was used for the fabrication of silk microneedles. The proposed method offers a simple, low cost and high throughput means for the mass production of high‐density microneedle masters towards the commercialisation of dissolving microneedles.
Total Synthesis of Eleuthoside A; Application of Rh-Catalyzed Intramolecular Cyclization of Diazonaphthoquinone
Authors: Kitamura Mitsuru , Othman Dina , Otsuka Kota , Takahashi Shuhei , Selim Khalid , El-Sayed Magda , Tantawy Atif , Okauchi Tatsuo
Published: November 2017

The first total synthesis of (±)-eleutherol and eleuthoside A, the natural cytotoxic substances extracted from medicinal Indonesian plant, is described. First, the synthesis of (±)-eleutherol has been ­accomplished in nine steps starting from bromo methoxy aldehyde with the aid of diazo-transfer chemistry approach. Second, a metal-­catalyzed intramolecular cyclization reaction of the corresponding ­diazonaphthoquinone led to the desired eleuotherol, which served as a precursor to eleuthoside A. Then, several glycosidation routes, using different glucosyl donors, were experimented to reach effective O-glycosidation of eleutherol. The only successful strategy involved Koenigs–Knorr glycosidation using peracetyl glycosyl bromide in the presence of Ag2O and quinoline. This strategy furnished our desired acetylated glycoside of β-configuration, regioselectively. Finally, deacetylation and successive separation of diastereomers were conducted to give eleuthoside A.
Indium(III) Iodide-Catalyzed Stereoselective Synthesis of β-Glucopyranosides by Using a Glucosyl Fluoride Donor with 2-O-Benzoyl-3,4,6-Tri-O-Benzyl Protection
Authors: Yu Lan , Xue Weihua , Ma Teng , Li Changwei , Zhang Zhan-xin , Wang Zhaoyan
Published: November 2017

We have developed a novel protocol for glucosylation by adopting a glucosyl fluoride donor with 2-O-benzoyl-3,4,6-tri-O-benzyl protection. The protocol is useful for the ready assembly of β-linked functional glycoconjugates, and the reaction accommodates a broad range of substrates. Conveniently, water-tolerant and commercially available InI3 is used as a catalyst, and no other additional reagent is required. The method involves an interesting process for glucosyl fluoride activation and, in particular, permits the stereoselective construction of partially benzylated glucopyranosides carrying a selectively removable 2-O-benzoyl group, which hold great potential as glycosyl receptors for building further 1,2-glycosidic linkages.
Pd-Catalyzed One-Pot Borylation/Intramolecular Asymmetric Arylation on α-Ketiminoamides: Innovative Approach to Chiral 3-Amino-2-oxindoles
Authors: Marques Carolina , Burke Anthony , Lawrence Simon
Published: November 2017

3-Amino-2-oxindole derivatives are a common framework found in many natural products and medicinal compounds and thus their synthesis is of significant importance. We report for the first time a one-pot approach for the synthesis of these compounds, using a bory­lation/intramolecular asymmetric arylation sequence starting from ­ortho-bromo-α-ketimino amide derivatives. Pd(OAc)2 was used as the pre-catalyst along with (R)-BINAP as the chiral source. We successfully obtained a family of 3-phenyl-3-(aryl-amino)-indolin-2-one derivatives (11 in total) with excellent yields (up to 98%) and enantioselectivities of up to 76% ee. The reaction is versatile and tolerant of a wide range of functional groups.
Copper-Catalyzed Oxidation of Hydrosilanes: A New Method for the Synthesis of Alkyl- and Siloxysilanols
Authors: Arzumanyan Ashot , Goncharova Irina , Novikov Roman , Milenin Sergey , Muzafarov Aziz
Published: November 2017

A simple method for the preparation of silanols from the corresponding hydrosilanes is reported. The method employs a commercially available oxidizing system based on CuCO3/t-BuOOH(aq) under relatively mild conditions (80 °C, atmospheric pressure) with acetonitrile as the solvent. Furthermore, we present a method that permits the Si−H group to be oxidized to a Si−OH group not only in triethylsilane, but also in bis(trimethylsiloxy)methylsilane, a siloxy derivative of hydrosilane. The products were isolated in gram amounts in yields of 61–73%.
New and Emerging Therapies for Uterine Fibroids
Authors: Fritton Kate , Borahay Mostafa
Published: November 2017

The pain, bleeding, and anemia associated with uterine fibroids debilitate many women. In addition to limited efficacy, the side effects of the currently used medical therapies prevent long-term use and nearly all pregnancies. Thus, women hoping to achieve pregnancy have limited options and usually opt for myomectomy. Once completed childbearing, many patients proceed with hysterectomy despite its risks and costs. Thus, there is a clear need for a new medical treatment for fibroids that is safe and effective. To this end, researchers have investigated several new treatments over the recent years, including both hormonal and nonhormonal ones. Some examples include selective progesterone receptor modulators, vitamin D, aromatase inhibitors, gene therapy, simvastatin, nanoparticles, epigallocatechin gallate, and intratumor collagenase injections. The aim of this article is to review and critically analyze the evidence (both laboratory and clinical) for these emerging therapies. We will discuss strengths and weaknesses of studies, areas where further evidence is needed, and finally deliberate on novel targets potentially amenable for development of future therapeutics.
Origin of Uterine Fibroids: Conversion of Myometrial Stem Cells to Tumor-Initiating Cells
Authors: Elkafas Hoda , Qiwei Yang , Al-Hendy Ayman
Published: November 2017

Uterine fibroids (UFs) are the most frequent gynecologic tumors, affecting 70 to 80% of women over their lifetime, Although these tumors are benign, they can cause significant morbidity and may require invasive treatments such as myomectomy and hysterectomy in premenopausal women at a cost of up to $34 billion per year. Many risk factors for these tumors have been identified, including environmental exposures to endocrine-disrupting chemicals such as genistein and diethylstilbestrol (and other environmental agents) resulting in hyper-responsiveness to hormone in the adult uterus and promotion of hormone-dependent UFs. Although the molecular mechanisms underlying the pathogenesis of UFs is largely unknown, a growing body of evidence implicates unfavorable early-life environmental exposure and multiple biological pathways express as potentially import contributors. In this article, we will review the role of genetic and epigenetics in the conversion of myometrial stem cells to tumor (fibroid) initiating cells, and their role in UF development.
Uterine Fibroids: Bridging Genomic Defects and Chronic Inflammation
Authors: El Andaloussi Abdeljabar , Chaudhry Zuni , Al-Hendy Ayman , Ismail Nahed
Published: November 2017

Uterine fibroids (UF; aka leiomyoma, myomas) are the most common benign tumors of female reproductive tract. They are highly prevalent, with 70 to 80% of women burdened by the end of their reproductive years. Fibroids are a leading cause of pelvic pain, abnormal vaginal bleeding, pelvic bulk symptoms, miscarriage, and infertility. They are the leading indication for hysterectomy, and costs exceed 34 billion dollars annually in the United States alone. Recently, somatic mutations in exons 1 and 2 of Med12 gene emerged as common UF driver mutations. Unfortunately, the detailed etiology of UF is not fully realized. Particularly, very little is known about possible dysregulation of inflammatory and immune processes and their possible contribution to UF pathogenesis. The notion on possible impact of altered estrogen and progesterone signaling in UF on inflammatory responses and DNA repair machinery that can conceivably lead to tumor-specific somatic mutation is indeed an intriguing concept which has some foundation in available observation in other hormonally responsive tissues. This review highlights and summarizes our current knowledge on the convergence of such pathways and their relevance for UF pathogenesis.
Patient-Centered Care and Uterine Fibroids
Authors: Marsh Erica , Chibber Shani , Saad Wael
Published: November 2017

Uterine leiomyomas are the most prevalent tumors in reproductive-aged women and are a major public health concern in the United States. Commonly known as fibroids, these benign tumors continue to be the leading cause of hysterectomy and are responsible for as much as $34 million in costs annually in the United States. Despite the increasing numbers of gains that are being made in understanding the pathophysiology of these tumors, relatively little work has been done to advance understanding of care delivery with regard to these tumors, specifically the patient perspective. Herein, we provide an overview of patient-centered care, a review of the available literature on the fibroid patient's perspective, and a discussion of opportunities to re-envision patient care with regard to fibroids.
Injury of the Carotid Artery during Endoscopic Endonasal Surgery: Surveys of Skull Base Surgeons
Authors: Rowan Nicholas , Turner Meghan , Valappil Benita , Fernandez-Miranda Juan , Wang Eric , Gardner Paul , Snyderman Carl
Published: November 2017

Objectives This study aimed to review endoscopic skull base surgeon experience with internal carotid artery (ICA) injuries during endoscopic endonasal surgery (EES) to provide an estimate of the incidence of ICA injury, the associated factors and identify the best training modalities for the management of this complication.

Design Anonymous electronic survey of past participants at a well-established endoscopic skull base surgery course and a global online community of skull base surgeons.

Main Outcome Measures Relative incidence of ICA injuries during EES, associated anatomic and intraoperative factors, and surgeon experience.

Results At least 20% of surgeons in each surveyed population experienced a carotid artery injury. Reported carotid artery injuries were most common during tumor exposure and removal (48%). The parasellar carotid artery was the most commonly injured segment (39%). Carotid artery injuries were more common in high-volume surgeons, but only statistically significant in one of the two populations. Attendance at a skull base course or courses did not change the incidence of carotid artery injury in either surveyed population. In both surveys, respondents preferred live surgeries or active (not computer simulated) training models.

Conclusions ICA injury is underreported and most common when manipulating the parasellar carotid artery for exposure and tumor dissection. Given the high morbidity and mortality associated with these injuries, vascular injury management should be prioritized and taught in a graduated approach by modern endoscopic skull base courses.
A Practical Approach to Neonatal Opiate Withdrawal Syndrome
Authors: Davis Jonathan , Devlin Lori
Published: November 2017

Perinatal opioid misuse and neonatal opioid withdrawal syndrome (NOWS) are a significant public health problem that has grown exponentially over the past decade. In the United States, a woman seeks emergency room care for prescription opioid misuse every 3 minutes and approximately every 25 minutes, a child is born with signs of drug withdrawal. The economic impact of perinatal opioid misuse is significant with annual hospital charges for NOWS in 2012 as $1.5 billion dollars. Perinatal opioid misuse is a complex, multifaceted problem that demands a multidisciplinary cross specialty approach. This article will review the current state of NOWS and provide medical practitioners with a practical guide to enhance evidence based practice.
Impact of Papillary Muscle Infarction on Ischemic Mitral Regurgitation Assessed by Magnetic Resonance Imaging
Authors: Bretschneider Christiane , Heinrich Hannah-Klara , Seeger Achim , Burgstahler Christof , Miller Stephan , Kramer Ulrich , Gawaz Meinrad , Nikolaou Konstantin , Klumpp Bernhard
Published: November 2017

Objective Ischemic mitral regurgitation is a predictor of heart failure resulting in increased mortality in patients with chronic myocardial infarction. It is uncertain whether the presence of papillary muscle (PM) infarction contributes to the development of mitral regurgitation in patients with chronic myocardial infarction (MI). The aim of the present study was to assess the correlation of PM infarction depicted by MRI with mitral regurgitation and left ventricular function.

Methods and Materials 48 patients with chronic MI and recent MRI and echocardiography were retrospectively included. The location and extent of MI depicted by MRI were correlated with left ventricular function assessed by MRI and mitral regurgitation assessed by echocardiography. The presence, location and extent of PM infarction depicted by late gadolinium enhancement (LGE-) MRI were correlated with functional parameters and compared with patients with chronic MI but no PM involvement.

Results PM infarction was found in 11 of 48 patients (23 %) using LGE-MRI. 8/11 patients (73 %) with PM infarction and 22/37 patients (59 %) without PM involvement in MI had ischemic mitral regurgitation. There was no significant difference between location, extent of MI and presence of mitral regurgitation between patients with and without PM involvement in myocardial infarction. In 4/4 patients with complete and in 4/7 patients with partial PM infarction, mitral regurgitation was present. The normalized mean left ventricular end-diastolic volume was increased in patients with ischemic mitral regurgitation.

Conclusion The presence of PM infarction does not correlate with ischemic mitral regurgitation. In patients with complete PM infarction and consequent discontinuity of viable tissue in the PM-chorda-mitral valve complex, the probability of developing ischemic mitral regurgitation seems to be increased. However, the severity of mitral regurgitation is not increased compared to patients with partial or no PM infarction.

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Comparison of the Effect of Cold Drink and Dexamethasone, and their Combined Effect on Children with Croup
Authors: Faraji-Goodarzi Mojgan , Taee Nadereh , Mohammadi-Kamalvand Mehrnoosh
Published: November 2017

Aims Croup is a clinical syndrome which included inspiratory stridor, coughing with a dog-like sound, noise obstruction and respiratory distress symptoms. This present study was conducted to compare the effects of cold drink and dexamethasone, and the effects of their co-administration on children’s croup.

Materials and Methods In this study, all patients with croup admitted to the emergency ward of Madani Hospital Khorramabad were divided through the simple randomized method into 3 groups after informed consents were taken from their parents. The first group was given cold drink, second group with dexamethasone (DM), and the third group were given the combined treatment simultaneously. The patients in the first and second groups who did not show signs of improvement received the simultaneous treatment similar to the third group. The data were analyzed using the SPSS software through descriptive statistics and inferential statistics including multi-field variance analysis and co-variance analysis.

Result The results of the study indicated a statistically significant between the 3 group in terms of improvement time-scale of croup clinical symptoms (P=0.001). There was no significant difference observed between the effects of other variables on improvement time-scale of croup clinical symptoms.

Conclusion The cold drink has less treating effect than DM and combined simultaneous treatment method. Also, DM had more influence than simultaneous treatment method. In addition, other variables including age, sex, birth weight, BMI, respiratory allergy and previous croup history did not influenced improvement time-scale and only type of intervention influenced improvement time-scale of croup clinical symptoms.
ω-3 Fettsäuren, Selen, Quecksilber: Können wir noch Fisch essen?
Authors: Friedrichsen Hans-Peter
Published: November 2017

Fisch liefert wichtige Nährstoffe, insb. die ω-3-Fettsäuren Eicosapentaensäure (EPA) und Docosahexaensäure (DHA) und kann das Risiko für zahlreiche chronische Erkrankungen verringern. Allerdings ist er zunehmend mit Schwermetallen belastet. Der Selen- und Quecksilbergehalt im Fisch entscheidet über Nutzen und Risiko.