bluuebunny/crossref_metadata_2025 huggingface dataset:
Transversalsymmetrische Gelenke im Berechnungstool CoMSys
Authors: Jahn Hannes , Zentner Lena
Published: September 2024

Vorgestellt wird eine Weiterentwicklung des Berechnungstools CoMSys
[1] zur Analyse und Optimierung von nachgiebigen Mechanismen.
Das auf der Theorie großer Verformungen stabförmiger Strukturen basierende
Programm ist ein effizientes Werkzeug um nachgiebige Mechanismen
hinsichtlich ihrer Verformung zu berechnen. Neben den
derzeit implementierten vollsymmetrischen Gelenken sollen auch transversalsymmetrische
Gelenke implementiert werden. Diese werden mit
Hilfe einer bereits vorgestellten Methode [2] in die Benutzeroberfläche
integriert.

Transversely symmetrical hinges in the CoMSys calculation tool
A further development of the calculation tool CoMSys [1] for the analysis
and optimization of compliant mechanisms is presented. Based on the
theory of large deformations of rod-like structures, CoMSys is an efficient
tool for calculating the deformation of compliant mechanisms. In addition
to the currently implemented fully symmetric hinges, transversely
symmetric hinges are also to be implemented. These are integrated into
the user interface using previously described methods [2].
Auslegung eines monolithischen Positioniermechanismus als Fünfgelenk mit Abwurfmechanismus
Authors: Artmann Lucas , Hensgens Vitus , Lüth Tim C.
Published: September 2024

Vorgestellt wird ein monolithischer Mechanismus für die automatisierte
Flüssigkeitshandhabung in der Zellzucht. Der Mechanismus nutzt Festkörpergelenke,
um Abrieb und potenzielle Kontaminationsquellen zu eliminieren.
Er ist als Fünfgelenk mit zwei Freiheitsgraden für die horizontale
Positionierung der Pipettenspitze ausgelegt. Über einen weiteren
Freiheitsgrad ist ein Wechsel zwischen Absaug- und Dosierpipette sowie
das Abwerfen der Pipettenspitzen implementiert. Der gesamte Mechanismus
ist so konstruiert, dass er keine über den Zellkulturen liegenden
Motoren enthält, was das Risiko von Kontaminationen weiter reduziert.
Der Mechanismus wird in einem Pipettierautomaten implementiert.

Design of a monolithic positioning mechanism as a 5-joint
with ejection mechanism for pipette tips
A monolithic mechanism for automated liquid handling in cell culture is
presented. The mechanism uses solid-state joints to eliminate abrasion
and potential sources of contamination. It is designed as a five-bar linkage
with two degrees of freedom for horizontal positioning of the pipette
tip. A further degree of freedom is used to switch between the aspirating
and dispensing pipette and to eject the pipette tips. The entire mechanism
is designed so that it does not contain any motors located above
the cell cultures, which further reduces the risk of contamination. The
mechanism is implemented in an automatic pipetting machine.
FACTORS AFFECTING LOCALS’ ATTITUDES TOWARDS TAX ALLOCATION IN THE TOURISM SPHERE (IN THE CASE OF UZBEKISTAN)
Authors:   Department of Digital Economics and Information Technologies, Samarkand Branch of Tashkent State University of Economics, Samarkand, Uzbekistan, SAFAROV Bahodirhon , TANIEV Akhmadjon ,   Department of Accounting and Banking, Samarkand Branch of Tashkent State University of Economics, Samarkand, Uzbekistan, JANZAKOV Bekzot ,   Department of Tourism, Silk Road International University of Tourism and Cultural Heritage, Samarkand, Uzbekistan, ALIQULOV Samariddin ,   Department of Green Business and Sustainable Development, Samarkand Branch of Tashkent State University of Economics, Samarkand, Uzbekistan, BAKHRAMOV Jakhongir ,   Department of Digital Economics and Information Technologies, Samarkand Branch of Tashkent State University of Economics, Samarkand, Uzbekistan
Published: September 2024

This article aims to analyze locals’ attitudes toward tax allocation in the tourism sphere in the Republic of Uzbekistan. The analysis is based on the survey data taken from 505 respondents. We explored the impact of the frequency of travelling, age, the importance of travelling, and total family income on people’s attitudes toward public financing of tourism using the ordinal logistic regression. The results show that increasing the frequency of travelling of each respondent increases the odds of people’s approval of financing tourism from taxes by two times. At the same time, surprisingly, the increase in family income reduces the probability of approving tourism’s budget financing. In brief, the research contributes to the stateof-the-art literature by analyzing factors affecting people’s opinions on tourism financing from tax inflow, which might play a crucial role in the development of tourism development strategies.
DNA polymorphism in loci associated with the adaptation of barley to environmental conditions, when comparing seed samples from archaeological excavations of the 12th century with the VIR collection accessions of different geographical origin
Authors: Semilet T. V. , Shvachko N. A. , Kovaleva O. N. , Shipilina L. Yu. , Khlestkina E. K.
Published: September 2024

When studying the DNA polymorphism of ancient seeds from archaeological excavations, and comparing them with modern ones, it is possible, depending on the evolutionary significance/neutrality of the identified differences, to either find traces of adaptation of genotypes used in ancient times to unfavorable environmental conditions, or to clarify the origin of the samples, establishing additional evidence of trade and economic ties between different regions in different eras. The purpose of this work was to study the DNA polymorphism by comparing the 12th-century barley seeds from the Usvyaty settlement of the Pskov Region and VIR collection accessions of different geographical origin using theCHIandELF3gene fragments sequencing data. Of the 18 polymorphic SNP loci identified in the studied genes during the analysis of the barley samples under study, seven SNPs were from the regions amenable for resequencing in ancient DNA samples. The identified allelic changes in those seven SNP loci were neutral and did not lead to amino acid substitutions, therefore they can be used for a comparative analysis of the sample origin. The haplotype revealed in ancient barley based on the seven studied SNPs did not completely coincide with any of the studied accessions from the VIR collection. At the same time, rare alleles showed similarities with a Belarusian cultivar ‘Krinichny’, and the frequently occurring ones with several accessions ofH. vulgare L. of different origin (Sweden, Denmark, Armenia), as well as withH. spontaneum(K. Koch) Thell.
Leiomiomas de la unión esofagogástrica y estómago proximal. Presentación de caso
Authors: Mena-Mosquera Hinler A. , Velásquez-Hincapié Sara , Ramírez-Ceballos Mariana , Bernardo A. Borráez-Segura Bernardo A. Borráez-Segura
Published: September 2024

Introducción. Los leiomiomas son tumores mesenquimales benignos, con muy bajo potencial de malignidad, poco frecuentes, con una presentación clínica variable y en su mayoría asintomáticos. Su hallazgo es incidental; los estudios endoscópicos y patológicos son importantes para diferenciarlos de otros tumores estromales gastrointestinales.
Caso clínico. Se presenta el caso clínico de una mujer de 50 años, con antecedente de resección en cuña gástrica por hallazgo de lesión en el fondo gástrico y funduplicatura de Nissen, con informe de patología de leiomioma. La paciente ingresó remitida a nuestra institución con disfagia y dolor epigástrico. La endoscopia mostró una lesión en la unión esofagogástrica, que se extendía a la región subcardial subepitelial, que fue confirmada por ultrasonografía endoscópica y tomografía.
Resultado. Se consideró que la paciente presentaba recaída tumoral después de una resección laparoscópica, que requirió deshacer una funduplicatura previa y enucleación parcial por vía laparoscópica, con resección en cuña de la mucosa firmemente adherida a la unión esofagogástrica, con una funduplicatura tipo Dor. Tuvo adecuada evolución posoperatoria.
Conclusiones. Los leiomiomas son tumores benignos infrecuentes, con rara transformación maligna. Generalmente son asintomáticos y su hallazgo es incidental. Los estudios endoscópicos y la confirmación histológica permiten su diagnóstico para definir el mejor manejo.
Penerapan Metode Scaffolding Menggunakan Gim Edukasi untuk Mengembangkan Kemampuan Komunikasi Matematis, Hasil Belajar, dan Efikasi Diri Siswa Sekolah Dasar
Authors: Sinambela Angela Natalia , Santoso Agus
Published: September 2024

Kemampuan komunikasi matematis dan efikasi diri merupakan faktor yang krusial bagi siswa dalam menyelesaikan soal cerita pada pelajaran Matematika yang berdampak terhadap capaian belajar siswa. Penelitian ini bertujuan untuk menganalisis perkembangan kemampuan komunikasi matematis, hasil belajar, dan efikasi diri siswa dalam menyelesaikan soal Matematika dengan perlakuan metode scaffolding menggunakan gim edukasi. Metode yang digunakan adalah Penelitian Tindakan Kelas (PTK) tiga Siklus terhadap 19 siswa sebagai subjek penelitian. Metode analisis data dalam penelitian ini menggunakan pendekatan campuran yang melibatkan analisis kuantitatif dan kualitatif. Elisitasi data diperoleh dari hasil tes, lembar observasi dan wawancara dengan siswa. Berdasarkan hasil penelitian ditemukan bahwa kemampuan komunikasi matematis menunjukkan peningkatan nilai N-Gain sebesar 0,3 dengan kategori sedang untuk setiap Siklus. Peningkatan kemampuan komunikasi matematis siswa berimplikasi pada capaian belajar siswa yang menunjukkan eskalasi dengan nilai rata-rata post-test dari Siklus 1 sampai Siklus 3 secara berturut turut yaitu: 74,1 ; 79,8 ; 81,4. Efikasi diri siswa dalam hal ketekunan dan kegigihan untuk menyelesaikan soal Matematika pada gim yang terdapat bantuan ataupun petunjuk juga memperlihatkan peningkatan yang signifikan. Dengan demikian, dapat disimpulkan bahwa metode scaffolding menggunakan gim edukasi digital dapat mengembangkan kemampuan komunikasi matematis, capaian belajar, dan efikasi diri siswa kelas IV SD XYZ Jakarta
The effect of exogenous and genetic factors on a decrease in bone mineral density in children with cystic fibrosis
Authors: Zhekaite E. K. , Kondratyeva E. I. , Voronkova A. Yu. , Trendeleva T. A.
Published: September 2024

Osteoporosis is acomplication of cystic fibrosis, the relevance of studying which is associated with an increase in the life expectancy of patients and an increase in the proportion of adults in the general patient population. The aim of the research is to study exogenous and genetic factors of bone mineral density reduction in patients with cystic fibrosis and healthy children. Methods. 100 children with cystic fibrosis and 61 healthy children over 6 years old were examined. All children underwent X-ray densitometry with the DEXXUM device (South Korea). Vitamin D intake, dietary calcium intake and physical activity were assessed using aquestionnaire. Vitamin D levels were assessed by enzyme immunoassay based on the blood content of its intermediate metabolite 25(OH)D. The determination of biochemical parameters was carried out in the CMD laboratory using the enzyme immunoassay method. Polymorphisms of the VDR, COL1A1, and CALCR genes were analyzed by restriction analysis (PDRF). Results. It was found that patients with CF (38%) are more likely to have low BMD compared with healthy children (18%). Low indicators of nutritional status had anegative impact on the BMD. The processes of osteoresorption prevail over the processes of osteogenesis in CF. The features of the course of the disease neutralize the influence of genetic factors that have been identified in healthy children. The effect of dietary calcium intake was significant for healthy children and had no effect on BMD in patients with CF, since patients adhere to acalcium-enriched diet. The effect of the CALCR and COL1A1 genes and dietary calcium intake on the BMD of healthy children has been established. Conclusion. In cystic fibrosis, the leading risk factors for decreased bone mineral density are: ahistory of meconium ileus, chronic infection with Pseudomonas aeruginosa, low nutritional status, and decreased pulmonary function (FEV1,% predicted). For healthy children, the influence of the CALCR and COL1A1 genes and dietary calcium intake are significant.
Differential diagnosis of parenchymal jaundice
Authors: Kandoba O. N.
Published: September 2024

The article presents to the attention of interested specialists (infectious disease specialists, gastroenterologists, pediatricians) information on the definition and classification of jaundice, the physiology of bilirubin metabolism, pathogenetic mechanisms of the development of hepatic forms of jaundice syndrome and the syndromes observed in this case, as well as diseases, both infectious and somatic, in which parenchymal jaundice occurs. Using aspecific clinical example, the features of the clinical course, diagnosis and differential diagnosis, and tactics of treatment of hepatic jaundice developed in a16-year-old teenager with chronic viral hepatitis C and Gilbert’s syndrome are analyzed in detail.
CHANGE STRUCTURE OF AGRICULTURAL LANDS ON FOREST STEPPE ZONE OF BASHKIR POST URAL SINCE SECOND HALF 20 CENTURE
Authors:   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia, Gimazetdinov V.D. , Tuktamyshev I.R. ,   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia
Published: September 2024

We analyzed modern use of arable lands of 1985 in forest-steppe zone of Post-Ural of the Republic of Bashkortostan. Climate is temperate continental. An average annual temperature is 1.6℃ and an average annual precipitation of 427.9 mm. The hottest month is July with an average temperature of 17.5 and the coldest month is January with an average temperature of -14.8℃. Modern agricultural lands usually are used as a hay (43%). Use can be caused with local cattle breeding as traditional horse breeding. Overgrowth captures by 25% of Pinus silvestris. Scot’s pine is growing better on dry lands because it captures more area of overgrowth.
ANDROSACE KUCZEROVII KNJASEV (PRIMULACEAE) – THE ENDEMIC OF SOUTH URALS AND ISSUES OF ITS PROTECTION
Authors:   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia, Muldashev A.A. , Maslova N.V. ,   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia, Elizarjeva О.А. ,   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia, Galeeva A.Kh. ,   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia, Chalitova (Tuytuynova) N.M. ,   Bashkir State Pedagogical University named after  M. Akmulla, Ufa, Russia
Published: September 2024

The authors dedicate this work to the memory of the famous researcher of the flora of the Southern Urals, Professor, Doctor of Biological Sciences Evgeniy Vasilyevich Kucherov, whose 100th birthday anniversary was celebrated on May 10, 2024. The species Androsace kuczerovii Knjasev (family Primulaceae) – endemic to the Southern Urals – was described in 1998 from the territory of the Republic of Bashkortostan (RB) by the famous botanist from Yekaterinburg M.S. Knyazev [Knyazev, 1998]. The species is included in the Red Book of the Republic of Bashkortostan, 3rd edition [2021] with regional protection status: 1) rarity status category: 1 – endangered species; 2) endangered status category: critically endangered (CR); 3) conservation status: I priority (immediate adoption of comprehensive measures is required, including the development and implementation of a strategy for the conservation of this species and (or) a program for their restoration (reintroduction) in the Southern Urals). In the Republic of Bashkortostan, three localities of the species are known on the eastern slope of the Southern Urals – in the Abzelilovsky (Ulugurtau ridge near the village of Makhmutovo, Mount Turpai near the village Ishkulovo) and Baymaksky (Irendyk ridge in the vicinity of the village of Kuseevo) regions. The features of ecology and biology, the size and condition of the population on the ridge Ulugurtau, limiting factors, and the measures taken and necessary to protect this species are considered.
GROWTH-STIMULATING ACTIVITY OF ENTEROBACTER LUDWIGII BLK BACTERIA IN OPTIMIZING THE CULTURE MEDIUM
Authors:   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia, Chetverikov S.P. , Timergalin M.D. ,   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia, Feoktistova A.V. ,   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia, Starikov S.N. ,   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia, Kendjhieva A.A. ,   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia, Hkudaygulov G.G. ,   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia, Bakaeva M.D. ,   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia
Published: September 2024

A method for optimizing the cultivation of Enterobacter ludwigii BLK and the treatment of wheat plants using a preparation based on this bacterium is proposed. By reducing the concentration of peptone and partially replacing it with an alternative nitrogen source – yeast extract – in the culture medium, the cost of producing the drug was reduced without reducing its effectiveness. It was found that the preparation, produced in a modified environment, activated root growth and promoted the accumulation of chlorophyll in bread wheat leaves. The stimulating effect was more pronounced with a combination of pre-sowing and post-emergence treatment.
GEMMOGENESIS IN VITRO IN WHEAT EMBRYONIC CALLUSES: MORPHOHISTOLOGICAL PECULIARITIES
Authors:   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia, Zinatullina A.E.
Published: September 2024

The promising area of biotechnological research of economically valuable plants is the use of callus cultures, in which such a pathway of morphogenesis in vitro as organogenesis is induced. One of the types of organogenesis is gemmogenesis in vitro, which consists in the development of formed buds that give rise to shoots. Despite the fact that this is a dead-end pathway of morphogenesis, which does not lead to further regeneration of plants without transferring the shoots to a nutrient medium of a different composition, it is nevertheless important to investigate the histological peculiarities of formation and development in calluses the buds as morphogenic structures. In calluses obtained from immature wheat embryos, histological methods have established that the process of gemmogenesis in vitro originates from the morphogenetic focus; morphohistological characteristics of the developing buds were revealed, which coincide with the anatomical parameters of the buds in natural conditions.
A renewed call for open artificial intelligence in biomedicine
Authors: Gitter Anthony , Fraser James S. , Gonen Tamir , Patro Rob , Wayment-Steele Hannah K. , Williams Alicia , Haibe-Kains Benjamin , Dunbrack Roland L. , Cook Cameron , Kundaje Anshul , Hoffman Michael M. , Carpenter Anne E. , Wankowicz Stephanie A. , Lindorff-Larsen Kresten
Published: September 2024

The excitement around and usage of artificial intelligence (AI) tools in scientific research is increasing across fields, but lax publication standards are resulting in papers "like grand mansions of straw, rather than sturdy houses of brick" (Kaelin Jr). In biomedicine, AI methods span fundamental biology to clinical applications, such as prioritizing chemicals as drug candidates, deciphering transcription factor-DNA binding preferences, detecting RNA modifications, learning the effects of cell treatments, and linking medical images with text annotations. Despite repeated insistence from experts that sharing AI training data, code, and model weights-the saved parameters required to make new predictions-are necessary best practices, they are not universal practices among authors or publishers. A mere 10% of surveyed biology journals require sharing analysis code. This abysmal status quo needs to be changed. Experimental biology communities show there is a path forward. Depositing macromolecular structure data in the Protein Data Bank was initially voluntary. Leadership from structural biologists about the importance of mandatory data deposition led to the creation of policies and their subsequent uptake at journals. Likewise, genomics researchers pioneered data sharing principles that guided funding agency policies. The scientific community must show similar resolve in establishing and uniformly applying policies for open AI in biomedicine.
The effect of speaker reliability on word learning in children: A replication study
Authors: Gangopadhyay Ishanti , Peters Lillian
Published: September 2024

This study aimed to replicate the in-person speaker reliability research conducted by Gangopadhyay & Kaushanskaya (2022; henceforth G&K) using a fully online methodology. Twenty children aged 4 to 6 years participated in a live video call with the experimenter and completed virtual tasks on a web-based platform. The experimental task mirrored that used in G&K, where children learned novel words from both a reliable and an unreliable speaker, followed by testing children’s novel word retention. Consistent with G&K's findings, children performed above chance in both conditions and retained novel labels taught by both speakers. These preliminary results suggest that speaker reliability is a robust cue, showing consistent effects across different data collection methods. Thus, online data collection can yield viable results, enhancing the accessibility, flexibility, and equity of participation in child language research.
Which Immigrants do Citizens Prefer? A Meta-Reanalysis of 96 Conjoint Experiments
Authors: Aviña Marco M. , Lee Taeku , Malik Mashail , Rasband Reed , Roman Marcel , Sethy Priyanka
Published: September 2024

In the last decade, an important literature in the social sciences has examined public attitudes toward immigrants in host societies. In it, a prominent experimental method---the conjoint design, where participants are tasked with rating or choosing between randomized profiles---has been used reliably to understand how immigrant characteristics shape admission preferences. We collate replication datasets from 96 individual studies spanning 1,424,293 immigrant profiles with 25 randomized attributes evaluated by 135,272 survey respondents from 32 countries. Meta-analyses reinforce well-established findings: economic, cultural, humanitarian, and procedural factors all influence evaluations. Our meta-reanalyses yield three novel insights. First, there is a broad-based consensus on immigration preferences between countries and a near-consensus within countries. Second, economic concerns have gained explanatory power over cultural concerns over time. Third, attribute-based preferences for immigrants vary considerably depending on people's overall support for immigration. These findings shed new light on ongoing debates and identify fruitful areas for future research.
The “Difficulties” in Fermat's Original Discourse on the Indecomposability of Powers Greater Than a Square: A Retrospect
Authors: Dedenko Grigoriy
Published: September 2024

A possible version of the original proof of the decomposability of whole degrees above the square which Pierre Fermat spoke of. This reconstructed evidence is discussed with some extra conclusions drawn from it.
Review of Russian Foreign Policy (1991-2024): From Western Cooperation to Great Power Identity
Authors: Rahaman Shafiqur
Published: September 2024

Russian foreign policy is a piece of conundrum which is covered by its national interest. The policy has been changed timely following pragmatic approach. The study examines in the initial phase of the post-Soviet period, Russia endeavored its hard and sole to integrate with the “civilized” Western world. But this integration did not achieve Russia’s national interest which led Russia to an anti-west-centric approach, the multi-polar world. In the stage Russia strategically engaged with Asia and the Middle East to reconstruct its post-soviet transitional period’s subdued image. In relation to former post-soviet republics, Russia gained modest profile in terms of security and economic. However, for showing great power identity, Russia directly betrothed in Syrian and Ukraine war which demands Russia needs a seat in great power table.
Shifting Resource Configuration of the Creative Businesses in the Perspective of Digital Economy
Authors: Adjie Fadhilla Sandra , Özgeldi Meriç , Fachira Ira
Published: September 2024

Extant literature has identified how the digital economy has transformed the types of resources available to creative businesses, both tangible and intangible. Since previous research on the digital economy’s influence over these resources is limited, yet remains pertinent in reshaping the resource configuration. By analyzing 25 articles, we identified and explored how resource allocation of the creative businesses shifts. As it is driven by the digital economy, which contributes to and shapes the overall digital economy. The findings highlight (1) types of resources in the creative businesses; (2) challenges and opportunities faced by creative businesses; (3) impact of digital economy on creative businesses’ resource allocation strategies.
Balancing Art: The Effect of Paintings Conceptual Ambiguities on Postural Control
Authors: Ganczarek Joanna , Pietras Karolina , Cox Ralf F. A. , Ruta Nicole
Published: September 2024

It has been shown that challenging contemporary art including conceptual ambiguities influences viewers’ preferences and eye movements. Here, we test whether such conceptual ambiguities (i.e., semantic violations and inconsistent titles) affect postural control. Research suggests that performing standard cognitive tasks influences postural control. However, the effects of challenging contemporary art on posture have never been studied before. We propose that semantic violations and inconsistent titles, two sources of conceptual ambiguities, should increase the perceived cognitive challenge and lead to a more stable and controlled posture. One hundred participants without formal art education viewed 20 paintings (10 with semantic violations, 10 without) in one of three conditions: no titles, consistent titles or inconsistent titles. Each painting was viewed for 25 seconds whilst viewers’ postural control was recorded. After presentation of each image participants assessed a given painting on 6 scales (understanding, complexity, ambiguity, being moved, drawn towards, and liking). We found that semantic violations and title inconsistency are challenging for the viewers. Moreover, semantic violations and the presence of titles (both consistent and inconsistent) were related to an increase in postural variability in the anterio-posterior direction. Inconsistent titles, on the other hand, were related to a lower variability in the medio-lateral direction and less postural control as evidenced by the recurrence quantification analysis. Similarly, perceived cognitive challenge was associated with lower postural variability and less postural control. Overall, the results suggest a close link between postural control and ongoing processing of semantic information.
An uncertainty quantification framework for a Zika virus epidemic model
Authors: Dantas Eber , Tosin Michel , Cunha Jr Americo
Published: September 2024

Uncertainty quantification is an important procedure when dealing with errors and discrepancies that are present in any modeling effort. This work presents a consistent uncertainty quantification framework for an epidemiological dynamical system, which is able to construct robust descriptions given a calibrated model. Since arbitrary choices of distributions for the input parameters can provide biased estimates and results, the maximum entropy principle is employed in the construction of the stochastic model to infer the most possibly unbiased probability density functions affected by the lack of information. The framework is applied on a SEIR-SEI compartmental system for the Brazilian Zika virus outbreak to study a stochastic scenario.
A computer-assisted discourse analysis of the original contribution of research on gender and entrepreneurship
Authors: Rotar Olga
Published: September 2024

In this paper, I analysed abstracts of 2000 articles on gender and entrepreneurship using a corpus-assisted discourse analysis approach, with the focus on the statements of the original contribution to the field. The study also examined whether gendered assumptions are embedded in the language used by scholars in the field. The themes that were identified are the gathering of the empirical evidence, conceptual development, theory exemplification, theory development, and theory advancement. The analysis has shown that the majority of studies focus on providing a better understanding to gender and entrepreneurship research (theory exemplification), whereas studies that contribute to the theory advancement are still scarce. This study is one of the first attempts to adopt corpus linguistics methods to examine the use of language in research on gender and entrepreneurship and to uncover hidden connections and thematic patterns.
Inventario de recursos para promover el bienestar universitario de la Pontificia Universidad Javeriana (PUJ) - Bogotá
Authors: Moreno Daniel Guerrero , Bermúdez Michelle Zuñiga , Melgarejo Juan Esteban Luengas , Duarte Juan Pablo Herrera , del Socorro Moreno Luna Isabel , Palencia-Sánchez Francisco
Published: September 2024

El bienestar global se define como la presencia de emociones positivas, ausencia de emociones negativas, y satisfacción con la vida. En instituciones de educación superior colombianas, se promueve un entorno integral con programas respaldados por leyes como la Ley 30 de 1992 y el Decreto 1295 de 2010 y a su vez, el ministerio de educación exige programas multi focales y complejos por lo que se planteó abordar el inventario que una universidad como la Pontificia Universidad Javeriana tiene para sus estudiantes, y consolidar las definiciones de este constructo. Se realizó una búsqueda en la literatura científica para definir bienestar y recurso en el contexto universitario, utilizando términos como "wellness" en bases como PubMed. Se revisaron los recursos disponibles en la universidad y se crearon gráficos ilustrativos. Luego, se diseñó una encuesta para recopilar información sobre los recursos de bienestar en cada facultad. Las respuestas se agruparon en seis categorías de recursos. En facultades específicas, se usó IA para generar resúmenes evitando sesgos. Este estudio avanzó el entendimiento del bienestar universitario en la Pontificia Universidad Javeriana, categorizando programas y revelando fallas y fortalezas en cada facultad. Aunque existe una visión conjunta desde la vicerrectoría, cada facultad gestiona el bienestar de forma independiente, lo que personaliza los enfoques, pero dificulta un análisis integral. Los recursos sociales son el punto fuerte, con mayor cantidad de programas, pero la mayoría de las facultades carecen de algunos recursos clave. Se recomienda que todas las facultades implementen todos los tipos de recursos para un bienestar integral.
Reconceptualizing the Digital Divide as Digital Disability: Implications for Health Equity
Authors: Jakobsen Glenn
Published: September 2024

In today’s digitally dependent world, access to technology is as vital as access to clean water or healthcare. This paper builds upon the recent concept of "digital disability," emphasizing the barriers individuals face when they cannot fully engage with digital platforms due to lack of access, literacy, or infrastructure. These barriers disproportionately affect vulnerable populations—such as the elderly, people with disabilities, and low-income groups—exacerbating existing health and social disparities. By applying the International Classification of Functioning, Disability, and Health (ICF) framework, the paper draws parallels between digital and traditional disabilities. It also explores the role of artificial intelligence (AI) and large language models (LLMs) as adaptive tools to bridge the digital gap. Policy recommendations focus on improving infrastructure, subsidizing devices and services, and implementing digital literacy programs. The paper frames broadband access as a public health imperative grounded in bioethical principles. Recognizing digital access as a fundamental right, the paper advocates for comprehensive strategies to empower individuals to thrive in an increasingly digital society, emphasizing the moral and practical need for adaptive solutions.
Spam, unwanted or unsolicited emails following the publication of preprints
Authors: Teixeira da Silva Jaime A. , Nazarovets Serhii
Published: September 2024

Spam, unwanted, or unsolicited emails, affect the daily lives of professional academics. In additional to potentially harmful content or links, deceptive spam can waste scientists’ time and resources. In this case study, we make note of journal-advertising spam that are sent to the authors of preprints after they are published. We examined 11 of the authors’ preprints that were published in 2023, finding that spam with the titles of six preprints were used in the email subject area, one in particular (a Research Square preprint) being the subject of 20 emails between March and July, 2023. In some cases, spam appeared very soon (within 1–3 days) after preprints were published while others had some typical characteristics of spamming journals and publishers: fake impact factors, appealing to authors’ ego, promising rapid publication times, etc. This small dataset suggests that spambots may be trawling preprint servers in a bid to try and capture new intellect that has been published as a preprint, sometimes even very soon after publication.
Accessibility of Finding Tuberculosis Case Actively, Separate Safely and Treat Effectively (FAST) Strategy for Early Detection of Suspected and Symptomatic Tuberculosis Patients: A Hospital Based Quantitative Study
Authors: Shrestha Merina , Singh Priyadarshini Shah , Rana Dilasha , Jayswal Aakash
Published: September 2024

Introduction: Tuberculosis is a contagious disease which has always been a challenge over the course of human history. It is known to spread mostly from persons with undiagnosed and suspected tuberculosis cases. Diagnosing tuberculosis in an early stage with effective treatment is one of the best ways to reduce the burden of tuberculosis. Finding cases Actively, Separate safely and Treat effectively (FAST) Strategy in Nepal, is a rapid diagnostic tool for rapid tuberculosis case detection.
Aims: To access tuberculosis case Actively, Separate safely and Treat effectively (FAST) strategy for suspected and symptomatic tuberculosis patients coming to the hospital for early case detection and also to identify patient’s health care behaviour, technical barrier during surveillance.
Methods: An observational quantitative study of active cough surveillance was carried at an entry point of  FAST corner of Nepalgunj Medical College Teaching Hospital, Banke from April 2023 to December 2023. Scrutinized data was obtained by purposive sampling method with sample size 128 from FAST corner.
Results: Maximum cases belonged to the aged group 65 and above having lower middle to lower socioeconomic status. Most of them were from joint family with contact history of tuberculosis in 35 (27.3) % of total cases. Out of total cases, 72 (56.25) % were confirmed with tuberculosis. Among those confirmed tuberculosis cases, multi drug resistance TB was found in 6 (4.7) %. Uses of mask was found significant (P< 0.05) in our study although number of these health care behaviour were less appropriate. Pneumonia was a significant association 17 (P = 0.004) with tuberculosis patient. Insufficient volunteers, and limited Gene xpert machine were major barriers to implement FAST strategy screening in Hospital.
Conclusion: FAST strategy is feasible tool in high tuberculosis burden healthcare settings in Nepal. However, the technical and behavioral factors should be managed to ensure an effective approach.
Krait bite: A Diagnostic Dilemma
Authors: Acharya Devendra , Yadav Preeti , B.K. Shyam Kumar , Ghimire Prasanna , Pandey Parash
Published: September 2024

In Nepal, fatalities resulting from snakebites are alarmingly common, yet the issue remains inadequately addressed, prompting experts to characterize it as an imminent but overlooked crisis. Among the venomous snakes, the Common Krait stands out for its exceptionally lethal venom, rich in neurotoxins that induce muscle paralysis. Particularly in rural areas, snakebites pose a significant threat to public health. However, the diagnostic challenge posed by patients with obscure medical histories devoid of known snakebite incidents is seldom documented in medical literature. In this context, we present the case of a 22-year-old male patient presenting with nonspecific symptoms and an indistinct medical background.
Neuronal Migration Disorders in Children; A Case Series highlighting importance of Neuroimaging in diagnosing Epilepsy
Authors: Patil Smita , Amit Vatkar  , Vijayan Vineetha
Published: September 2024

Background: Neuronal migration disorders comprise a heterogeneous group of neurological conditions caused by abnormal neuronal positioning during brain development. We aimed to study the clinical profile, neuroimaging features, genetics, and treatment of neuronal migration disorders.
Methods: This was a retrospective case series of 15 pediatric patients diagnosed with neuronal migration disorders at a tertiary care hospital over a 5 year period. Detailed clinical evaluation, neuroimaging, EEG, and genetic analysis were performed.
Results: Global developmental delay and epilepsy were the most common presenting features. Neuroimaging revealed spectrum of cortical dysgenesis including pachygyria, polymicrogyria, lissencephaly, heterotopia, and schizencephaly, predominantly involving fronto-parietal regions. MRI coupled with clinical findings enabled definitive diagnosis. Genetic analysis identified mutations in PAFAH1B1, ADGRG1, DHDDS, TMTC3, and other genes.
Anti-seizure medications like valproate, levetiracetam, and clobazam were the mainstay of therapy. Non-pharmacological interventions including physiotherapy, occupational therapy, and speech therapy were employed.
Conclusion: This study demonstrates the diverse clinical, genetic, and radiological spectrum of neuronal migration disorders. Comprehensive evaluation along with neuroimaging and genetic analysis enables accurate diagnosis and guides management. A multimodal approach is required focusing on seizures, neurodevelopmental disabilities, and improving quality of life.
Extended Endoscopic Endonasal Approach for Tuberculum Sella Meningiomas: Lessons Learned
Authors: Yerragunta Thirumal , Yerramneni Vamsi Krishna , Kanala Ram Nath Reddy , Rangan Vasundhara , Karanth Vishwa Kumar K S , Shahid Mohammed , Akurati Sri Venkata Sasank , Rao Mahendrakar Dasagriva
Published: September 2024

Midline meningiomas arising from the anterior skull base, particularly the planum sphenoidale and tuberculum sellae (TSM), present unique challenges due to their proximity to vital structures such as the optic apparatus. Traditionally approached via transcranial routes, these lesions often lead to chronic compression of optic nerves, resulting in visual impairment. With advancements in endoscopic skull base surgery, extended endonasal endoscopic (EEE) approaches have emerged as a viable alternative. This study aims to analyze the technical nuances and outcomes of EEE approach for excision of anterior skull base meningiomas presenting with visual impairment.
Thirteen patients with TSM and visual impairment underwent EEE surgery at a single institute. Clinical, radiological, and ophthalmological evaluations were conducted pre- and post-operatively. Surgical techniques involved meticulous tumor excision, preservation of vital structures, and multi-layer skull base reconstruction. Visual outcomes, extent of resection, complications, and endocrine function were assessed.
The study demonstrated significant visual improvement in 76.9% of patients, with no cases of permanent visual deterioration. Complete tumor excision was achieved in the majority, with near-total excision in selected cases due to adhesions or tumor characteristics. Complications included CSF rhinorrhea, meningitis, and transient visual field defects, all managed effectively. Endocrine function remained largely unaffected postoperatively, except for one case of diabetes insipidus.
The EEE approach offers distinct advantages in accessing and excising anterior skull base meningiomas, particularly in achieving optic nerve decompression while preserving vision. Despite challenges associated with larger tumors and adhesions, careful surgical planning and techniques can optimize outcomes. This study contributes to the growing evidence supporting the efficacy and safety of EEE approaches in treating anterior skull base meningiomas, emphasizing the importance of surgical expertise and patient selection.
Intra Arterial Tirofiban in the Peri Operative Priming for Intracranial Stent Deployment in Aneurysms – A cross Sectional Study
Authors: Manjooran Kavitha Raju , Palatty Princy Louis , Ramachandran Sreehari Nirmal , Menon Sajesh Karunakara
Published: September 2024

Introduction: Tirofiban is a glycoprotein IIb/IIIa receptor antagonist that inhibits platelet aggregation. Primary and secondary objectives of this study were to determine the efficacy and to determine the safety profile of intra arterial tirofiban in the peri operative priming for intracranial stent deployment in aneurysms respectively.
Materials and methods: This was a cross sectional study in a tertiary care centre in Kerala. Patient admitted with sub arachnoid haemorrhage/aneurysm posted for endovascular stent associated procedures and willing for the study were selected. The pre procedure assessment of neurological status was done. Patient underwent the procedure where peri operative priming with intraarterial tirofiban was given. The development of any neurological deficits within 24 hours was assessed using Glasgow coma scale and National Institute Health Stroke Scale. Laboratory blood parameters before and after procedure were also reviewed.
Results: Study involved 58 patients with aneurysm who were given intraarterial tirofiban. No significant difference (p value 0.521) in Glasgow coma scale on admission (14.89 ± 0.462) and on discharge (14.74 ±1.650). Analysis was done using SPSS version 20.00. Paired samples T test and Wilcoxon Signed Rank Test were used.
Conclusion: Results showed that intra arterial tirofiban is effective and the procedure was uneventful with no complications. Patients recovered well and the hospital stay was of minimum duration.
Prevalence of deviations in hematological and biochemical parameters in patients with Delirium Tremens
Authors: Parbalkar Ashana , Deshmukh Rohit , Kale Sanjiv S.
Published: September 2024

Introduction: Delirium Tremens (DTs) is an acute and severe form of alcohol withdrawal which if left untreated could lead to significant mortality. Identification of parameters which may lead to the progression of alcohol withdrawal to delirium tremens will aid in early initiation of appropriate treatment which in turn may help reduce the mortality rates. This study was undertaken to assess the prevalence of haematological and biochemical deviations in Delirium tremens and to assess the corelation between these deviations and severity of delirium tremens.
Materials and Methods: A cross-sectional research was carried out at a Tertiary Care Centre over 6 months. Confusion Assessment Method (CAM) tool was applied as a delirium screening tool for patient selection. After gaining consent, 89 patients who met the criteria for inclusion were enrolled. Demographic and clinical data of the patient was collected and laboratory investigations were recorded. Delirium Index (DI) was applied in conjunction with the Modified Mini-Mental State (3MS) Test as a cognitive screening tool. SPSS-PC -25 version was used for data analysis. The Shapiro-Wilk test was used to investigate normal distribution. The difference in means between the groups was investigated using student t-test or Mann-Whitney U-test. Qualitative data were expressed in frequency and percentage. Spearman correlation coefficient was used to see correlation between different quantitative parameters. Statistics were deemed significant at a P <0.05.
Results: Male gender, older age, unemployment, anemia, thrombocytopenia, hyponatremia, hyperbilirubinemia and raised SGOT were identified as potential risk factors for developing Delirium tremens. Anemia, hyponatremia, hyperbilirubinemia, and raised SGOT and ALP levels were identified as potential risk factors for worsening the severity of delirium
Conclusions: Assessment of demographic details and deviations in laboratory parameters helps in identification of risk factors for developing Delirium tremens aiding in early intervention which prevents the worsening of the severity of delirium.
Empirical Evidence on Status of Street Vendors in Nepal amid COVID-19: A Structural Equation Modeling Approach
Authors: Bista Sushmita , Adhikari Dipak Bahadur , Dhakal Krishna
Published: September 2024

Background: During the COVID-19 pandemic, street vending businesses faced severe disruptions, exacerbating poverty and livelihood challenges for vendors. The government's neglect of this sector has further intensified these issues, highlighting the need for a comprehensive analysis of the situation.
Objectives: This study aims to investigate the impact of COVID-19 on street vendors in Kathmandu Valley. Specifically, it explores the relationships between poverty, unemployment, and street vending, and examines the role of migration as a mediating factor.
Methods: An explanatory research design was employed, utilizing a non-probability convenience sampling technique to collect data from 202 street vendors. Data were gathered using KOBO Toolbox and a structured questionnaire. Both descriptive and inferential statistics were applied, with Structural Equation Modeling (SEM) used to analyze relationships and impacts.
Results: The analysis reveals a significant impact of poverty on unemployment among street vendors during the pandemic. Migration has a notable influence on street vending and unemployment, serving as a mediator between poverty and street vending activities. Domestic migration, in particular, has been pivotal in enhancing street vending in Kathmandu Valley.
Conclusion: The study underscores the need for regulatory authorities at central, provincial, and local levels to develop a legal and political framework to support street vendors. Implementing such measures could significantly improve their status and mitigate the adverse effects of the pandemic on their livelihoods.
Paper Types: Research Paper
Keywords: Poverty, Migration, Street vending, Informal sector, Structural Equation Modelling, Nepal
JEL Classification: E26, O17