bluuebunny/crossref_metadata_2025 huggingface dataset:
Bicycle Speedometer Plus
Authors: Mechlinski Thomas , Wübbelmann Jürgen , Hagemann Ralf , Korovin Nikita , Sanchez Amanda Abós , Goyal Nichiket
Published: March 2022

The European Project Semester program at the University of Applied Science Osnabrück deals mainly with engineering projects in different engineering domains. Developing a product based on complex technical requirements and economic concerns, such as cost-sensible development and marketing and environmentally-friendly design, are goals of a successful project during the one-semester internship at Osnabrück for a multicultural project team. In 2018, a team of four students received the task of developing a speedometer for bicycles with a brake light to enhance the rider's safety, especially in an urban environment. Besides the technical challenges, the team developed a marketing plan for the product. To the students, it was an excellent opportunity to understand the benefits and risks of working in a multicultural team and the necessity of following strict project management guidelines to finish a project as a team successfully.
Design and Analysis of a Tunable Rectangular Microstrip Slot Antenna for Narrow Band Internet of Things Applications at 1800 MHz
Authors: Raveendra Muddineni , U. Saravanakumar , Choppa Venkatesh , Pedapalli Saam Prasanth Dheeraj , Chepuri Narasimha Rao , Palivela Venkata Naga Ravi Teja
Published: March 2022

This chapter presents a tunable rectangular slot antenna on a Rogers RT/duroid 5880 (tm) substrate for narrowband internet of things applications. The proposed antenna has an operating frequency from 1601.20 MHz to 2051.90 MHz (tunable operating frequency range). The resonant frequency can be tuned by adjusting the length of the antenna as the application requirement. At each tuning step, the proposed antenna has sufficient bandwidth to fulfil the requirement of narrow band internet of things. The amount of power transmitting from the proposed antenna has been investigated at different aspects of the antenna. The proposed antenna has the ability to transmit above 99% at resonating frequency. All the analysis of the proposed antenna has been carried out in high frequency structural simulation. For the performance validation of the proposed antenna, it has been simulated in FEKO tool and its return loss behavior has been compared with HFSS results.
Development and Introduction of Fexinidazole into the Global Human African Trypanosomiasis Program
Authors: Valverde Mordt Olaf , Tarral Antoine , Strub-Wourgaft Nathalie
Published: March 2022

In this article, the authors show the strategy used to streamline the introduction of fexinidazole, the first all oral treatment of human African trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense. The dose range was determined in phase 1 studies and a significant food effect was observed, which was tested with field-adapted meals. The pharmacokinetic profile required definition of a higher loading dosage for the first 4 days and administration of the daily dose together with a typical local meal to optimize product absorption and rapidly achieve drug steady state. This allowed for a combined phase II/III pivotal study directly after phase I trials. Partnerships with highly engaged actors from endemic country control programs and international research institutions started early through the HAT platform, building on an agreed target product profile (TPP), establishing a regulatory plan early and transparently including endemic countries in the research and data flow. A key element that enabled a quick start to access activities was preparing for World Health Organization guidelines early and starting the process prior to registration. Distribution plans were identified and supply was established from the start, by taking advantage of the existing supply agreement between the producers of all HAT drugs (Sanofi and Bayer) and the WHO. Pharmacovigilance and phase 4 studies were nested into wider implementation activities. Targeted sequential introduction into national programs was prioritized, based on medical need and epidemiologically updated information.
De la biostatistică la exploatările forestiere şi invers
Authors: Horodnic Sergiu Andrei
Published: March 2022

Modul de proiectare si de desfăşurare a lucrărilor de exploatare a lemnului se bazează pe metode statistice de calcul al volumului ce urmează a fi valorificat. În încercarea de a contabiliza realitatea naturală apar anumite probleme practice care par să fie minimalizate în prezent şi care pot determina o percepţie generală negativă a activităţii din domeniul forestier, mai ales pentru nespecialişti. Pe de alta parte, apare riscul ca erorile în plus (peste limita de toleranţă), involuntare sau nu, să rămână neobservate şi să fie speculate de cei ce valorifică lemnul obţinut. Acest editorial aduce în atenţie doar câteva dintre aceste aspecte în dorinţa de a elimina anumite „inconsecvenţe” în abordarea lor practică.
Contribuții la cunoașterea distribuției și biologiei speciei Retinia resinella (Lepidoptera: Tortricidae) în România
Authors: Olenici Nicolai , Semeniuc Fecioru Anca-Ionela
Published: March 2022

Retinia resinella (Linnaeus, 1758) este o specie demult semnalată în fauna României, dar despre care există puține informații referitoare la răspândirea ei în țara noastră și la biologia ei. Obiectivul lucrării de față este acela de a contribui la o mai bună cunoaștere a situației sub cele două aspecte menționate. Pentru aceasta, s-au efectuat observații și s-au recoltat lujeri de jneapăn (Pinus mugo Turra) cu gale provocate de larvele acestei specii din cinci masive montane situate în Carpații Orientali de unde specia nu fusese semnalată anterior: Călimani, Giumalău, Suhard, Rodnei și Maramureșului, la altitudini de 1680-1790 m. Identificarea moliei s-a făcut după specia gazdă pe care erau galele colectate, după caracteristicile acestora și după aspectul larvelor găsite în galele noi. Totodată s-au stabilit anii în care s-au format lujerii cu gale, respectiv anii în care s-a produs zborul adulților acestei molii. Determinarea anilor s-a făcut după creșterile anuale în lungime ale ramurilor, precum și după numărul de inele anuale ale acestora. Prin investigațiile efectuate s-a evidențiat faptul că specia este prezentă și trăiește pe jneapăn în toate cele cinci masive montane, iar zborul are loc atât în anii pari, cât și în anii impari. Prin urmare, se poate spune că arealul speciei în țara noastră este mult mai larg decât se cunoștea anterior și că este foarte probabil ca specia să fie prezentă și în alte locuri unde cresc pini, în special P. sylvestris L. și P. mugo. Proporția relativ mare a galelor de pe lujerii formați în anii impari sugerează existența la altitudini mari cel puțin a unui segment important din populație care își incheie dezvoltarea abia în trei ani, nu în doi ani, așa cum este acreditat în literatură, și nu este exclus să fie trei cohorte care se dezvoltă după un ciclu de trei ani. Investigații suplimentare sunt necesare pentru a clarifica acest aspect.
Analiza comparativă a modalităților de valorificare a lemnului la nivelul B.E. Tomnatic
Authors: Popa Andrei , Cuciurean Cosmin
Published: March 2022

Studiul oferă o analiză comparativă a modalităților de valorificare a lemnului din perioada 2018-2019, la nivelul B.E Tomnatic. Comercializarea masei lemnoase provenite din fondul forestier proprietate publică se poate realiza atât ca lemn pe picior, cât și ca lemn fasonat la drum auto. Studiul oferă o imagine asupra modalităților de valorificare a masei lemnoase, prin care se identifică cea mai eficientă modalitate din punct de vedere economic, de valorificare a lemnului, ținând cont de caracteristicile partizilor (tipul de produs, distanța de colectare, volum). Analiza s-a realizat pentru un volum de 49.684 m3, respectiv 120 de partizi. În raport cu modalitatea de valorificare, 65 de partizi (20.623 m3) au fost valorificate prin vânzarea lemnului pe picior, iar 55 de partizi (29,061 m3) prin vânzarea lemnului fasonat la drum auto. Analiza comparativă a celor două modalități de valorificare s-a realizat prin intermediul coeficienților de creștere a prețului. În cazul produselor accidentale I rata de creștere a prețului de vânzare față de prețul APV este mai scăzută în cazul valorificării lemnului fasonat la drum auto (23%) comparativ cu lemnul valorificat pe picior (28%). Rata de creștere a prețului de vânzare față de prețul APV, în cazul produselor secundare și accidentale II, este semnificativ mai mare în cazul valorificării lemnului fasonat la drum auto (76%, respectiv 93%) față de lemnul vândut pe picior (16%, respectiv 11%). În cazul produselor principale nu a fost posibilă o comparație a eficienței celor două modalități de valorificare a lemnului, deoarece aceste produse s-au valorificat preponderent ca lemn pe picior, dar rata de creștere a prețului de vânzare față de prețul de APV a fost de 58%.
Fragmentarea și conectivitatea la nivelul peisajelor din ecoregiunea Munților Carpați - sinteză
Authors: Mustățea Mihai
Published: March 2022

Fragmentarea și conectivitatea utilizării terenurilor influențează interacțiunile dintre oameni, flora și fauna din cadrul peisajelor montane localizate în zone puternic antropizate, precum este cazul Europei. Munții Carpați reprezintă o ecoregiune extrem de sensibilă la schimbări, deoarece include atât zone dominate de oameni în care se desfășoară activități economice, cât și ecosisteme naturale cu valoare ridicată de conservare și biodiversitate bogată. Scopul lucrării de față a fost reprezentat de realizarea unei sinteze a literaturii științifice legate de fragmentarea și conectivitatea peisajelor montane carpatice. Din punct de vedere metodologic, au fost realizate interogări în baza de date internațională ISI Web of Knowledge, iar termenii de căutare utilizați au fost „Munții Carpați”, „fragmentare” și „conectivitate”. Rezultatele au relevat prezența unui număr de 70 de studii, majoritatea fiind destinate evaluării conectivității habitelor mamiferelor protejate prin intermediul metodei costului minim, teoriei grafurilor și metricilor peisagistice. Importanța rezultatelor constă în conturarea unei imagini de ansamblu asupra cele mai sensibile probleme de mediu cu care se confruntă zonele montane caracterizate de prezența unei biodiversități bogate, respectiv a evidențierii celor mai utile metode cantitative destinate modelării modificărilor la care sunt supuse ecosistemele montane, ca urmare a presiunii umane.
Surprinzătoarea simplitate a tratamentelor adecvate stejăretelor pure și amestecurilor cu stejar
Authors: Nicolescu Valeriu-Norocel , Ghinescu Mugurel Nicolae , Mihăilescu Gheorghe
Published: March 2022

În contextul prezent, al silviculturii participative și multifuncționale, regenerarea naturală a stejarului pedunculat (Quercus robur L.), în arborete pure sau amestecate, constituie o problemă majoră a silviculturii europene. În țări ca Franța, Croația, Marea Britanie, unde stejarul pedunculat fructifică relativ frecvent (de la 2-3 ani la 5-6 ani, rareori 8-10 ani), specia se regenerează sub masiv, dominant prin tăieri succesive, cu o perioadă generală de regenerare scurtă (maximum 4-5 ani), caracteristică speciilor de lumină. În România, specia a fost regenerată în trecut tot cu tăieri succesive, considerate însă necorespunzătoare ecologiei stejarului pedunculat prin favorizarea speciilor de amestec, mai rezistente la umbră. În consecință, s-a trecut, mai ales după anul 1948, la regenerarea sa prin tăieri în ochiuri, cu o perioada de regenerare a ochiurilor de 2-4 ani, respectiv de 10-15 ani la nivel de arboret. În condițiile stejăretelor pure sau amestecate, aplicarea tratamentului nu trebuie însă sa urmărească respectarea perfectă a tehnicii teoretice a tratamentului tăierilor în ochiuri, ci trebuie corelată cu instalarea, creșterea și dezvoltarea regenerării naturale, care adesea este neuniformă și neregulată. De aceea, în opinia autorilor, tratamentul recomandat pentru regenerarea stejarului pedunculat ar trebui să fie o combinație între tăierile în ochiuri și cele succesive, care să urmărească și limitarea vătămărilor de exploatare.
Despre Eurocoduri și posibilitatea implementării lor la proiectarea barajelor pentru corectarea torenților
Authors: Ciornei Ioan
Published: March 2022

Lucrarea de față își propune să prezinte Eurocodurile, ca parte a activității de standardizare in domeniul construcțiilor,  la nivel european,  să sintetizeze principiile acestora și sa analizeze, constatând demersurile făcute de către alte tari,  posibilitățile de aplicare la dimensionarea barajelor pentru corectare torenților.

In tarile europene cu tradiție in domeniul activității de corectarea a torenților exista preocupări pentru adaptarea standardelor existent la principiile Eurocodurilor. Aceste preocupari intampina dificultati de rezolvare din cauza unor actiuni / solicitari care nu sunt integrate in Eurocoduri datorită caracterului special al lucrarilor de corectarea atorentilor.
ForCrops: Estimarea producției supraterane de biomasă lemnoasă din culturile forestiere cu creşteri rapide, prin scanare laser terestră
Authors: Dănilă Iulian
Published: March 2022

ForCrops - Evaluarea directa a productivității de biomasa din culturile forestiere cu ciclul scurt de producţie (SRF) cu scanerul laser terestru (TLS), este un proiect finanțat de  Unitatea Executiva pentru Finanțarea Învățământului Superior, a Cercetării, Dezvoltării și Inovării (UEFISCDI) prin programul 1 – Dezvoltarea sistemului național de cercetare-dezvoltare, subprogramul 1.1. – Resurse umane (Proiect de cercetare postdoctorală). Scopul principal al acestui proiect este de a estima biomasei lemnoase pe părți componente de arbore cu ajutorul tehnologiei TLS în vederea calibrării unor ecuații alometrice în condițiile colinare din NE României. Se urmărește în acest sens dezvoltarea unui protocol de scanare complet pentru aceste culturi, crescând precizia de estimare a biomasei, scăzând efortul și timpul de lucru în teren, cât și oferirea către industriei a unui instrument pragmatic.
Akuzmatyczność filmowych efektów dźwiękowych. Medialna mistyfikacja foley w kontekście sound designu
Authors: Nożyński Szymon
Published: March 2022

Acousmaticity of Film Sound Effects: Media Mystification of Foley in the Context of Sound Design

The text is about the foley profession, an important specialty performed as part of film sound design, at the post-production stage. What’s important here is both, the foley artist’s body, which becomes an instrument, and the ontology of created sounds, which are inserted into the finished film and synchronized with the picture. The author wonders if there is still a place for foley artists in the digital reality and common computerization of work. But the most important issue concerns the nature of sounds themselves, in the context of their production, acousmatics and the ubiquitous sound design.

What is the sound implemented into the picture, does the picture give credence to the sound, even though the sound is “substituted” because it is produced in the studio? The situation is debatable, in the context of acousmatic listening (i.e. without the context of the source), because the picture provides a substitute context for the sound, and the viewer (listener) accepts this audio-visual relationship without reservation (as long as the sound is prepared well). Especially since by going to the cinema, the viewer agrees to a form of manipulation in the name of entertainment. Usually he or she is not aware of the mystification in the field of sound, which - within the oculocentric perception ‒ for him or her is only a complement to the picture, although, in fact, it plays a fundamental role in understanding what is happening on the screen. Other topics discussed in the text concern the communicativeness of sound and the historical background of the foley profession. Also important are the interrelations between foley and sound design and other areas of sound activity, as part of the preparation of all the audio layers of a film.
Stefana Morawskiego krytyka postmodernizmu
Authors: Oziębłowski Mariusz
Published: March 2022

Stefan Morawski’s Critique of Postmodernism

The matter under consideration is Stefan Morawski’s criticism of postmodernism. The author presents Morawski’s main arguments against postmodernism and analyzes their accuracy for the Richard Rorty’s and Francois Lyotard’s theories. In addition to this the author considers the impact of the art on the possibility of integration consumer society.
A Novel Method for Path Planning of Mobile Robots via Fuzzy Logic and ant Colony Algorithem in Complex Daynamic Environments
Authors: Purian A. Fatemeh Khosravi , Sadeghian B. Ehsan
Published: March 2022

Researches on mobile robot path planning with meta-heuristic methods to improve classical approaches have grown dramatically in the recent 35 years. Because routing is one of the NP-hard problems, an ant colony algorithm that is a meta-heuristic method has had no table success in this area. In this paper, a new approach for solving mobile robot navigation in dynamic environments, based on the heuristic feature of an optimized ant colony algorithm is proposed. Decision-making influenced by the distances between the origin and destination points and the angle variance to the nearest obstacles. Ideal paths are selected by the fuzzy logic. The proposed ant colony algorithm will optimize the fuzzy rules’ parameters that have been using to On-line (instant) path planning in dynamic environments. This paper presents a new method that can plan local routs all over the area and to guide the moving robot toward the final track. Using this algorithm, mobile robots can move along the ideal path to the target based on the optimal fuzzy control systems in different environments, especially in dynamic and unknown environments.
Automatic Generation of Fuzzy Classification Rules from Data
Authors: Al-Shammaa Mohammed , F. Abbod Maysam
Published: March 2022

In this paper, we propose a method for automatic generation of fuzzy rules for data classification. The proposed method is based on subtractive clustering optimized using genetic algorithm. It searches for the FIS structure and number of rules that have the highest fitness value. Multiple performance measures are incorporated into the fitness function to address the problem of imbalanced data. Fitness function includes both training and validation to avoid data over-fitting. Classification performance of the proposed method is evaluated using different data sets and results are compared to those of a number of models generated by fuzzy cmeans clustering with various cluster numbers. Results show that the proposed method has better accuracy and a well compromised sensitivity and specificity.
Sensorless Sliding Mode Control of Induction Motor Using Fuzzy Logic Luenberger Observer
Authors: Bennassar A. , Abbou A. , Akherraz M. , Barara M.
Published: March 2022

Many industrial applications require high performance speed sensorless operation and demand new control schemes in order to obtain fast dynamic response. In this paper, we present a speed sensorless sliding mode control (SMC) of induction motor (IM). The sliding mode control is a powerful tool to reject disturbances. However, the chattering phenomenon presents a major drawback for variable structure systems. To decrease this problem, a saturation function is used to limit chattering effects. A Luenberger observer based on fuzzy logic adaptation mechanism is designed for speed estimation. Numerical simulation results of the proposed scheme illustrate the good performance of sensorless induction motor and the robustness against load torque disturbances.
Fuzzy Delay Tumor Growth with Quiescence Cells: Stability of Steady States
Authors: Maan N. , Barznji K. , Aris N.
Published: March 2022

This paper presents a system of delay tumor growth that describes an interaction between the proliferating and quiescent cells tumor. This system is fuzzified by parametric form of α-cut representation of symmetric triangular fuzzy number. The steady state and linear stability of fuzzy tumor growth system with quiescence and without quiescence cells are determined and analyzed. Here, we show that the trivial steady state of the system with quiescence is stable for τ =0 by Routh Hurwitz conditions. For increasing delay the steady state is unstable by using Strum theorem.
Fuzzy Semantic Models of Fuzzy Concepts in Fuzzy Systems
Authors: Wang Yingxu
Published: March 2022

The fuzzy properties of language semantics are a central problem towards machine-enabled natural language processing in cognitive linguistics, fuzzy systems, and computational linguistics. A formal method for rigorously describing and manipulating fuzzy semantics is sought for bridging the gap between humans and cognitive fuzzy systems. The mathematical model of fuzzy concepts is rigorously described as a hyperstructure of fuzzy sets of attributes, objects, relations, and qualifications, which serves as the basic unit of fuzzy semantics for denoting languages entities in semantic analyses. The formal fuzzy concept is extended to complex structures where fuzzy modifiers and qualifiers are considered. An algebraic approach is developed to manipulate composite fuzzy semantic as a deductive process from a fuzzy concept to the determined semantics. The denotational mathematical structure of fuzzy semantic inference not only explains the fuzzy nature of human semantics and its comprehension, but also enables cognitive machines and fuzzy systems to mimic the human fuzzy inference mechanisms in cognitive linguistics, cognitive computing, and computational intelligence.
Econometric Models for the Estimation of the Commercial Value of Residential Real Estate Objects in Latvia
Authors: Ruzha Oksana , Voronov Victor , Tambovceva Tatjana
Published: March 2022

Real estate market formation in Latvia occurs in the conditions of practical absence of a single system of methodological approaches to real estate estimation adapted for the Latvian conditions. In the article it is proved that along with individual estimation it is possible to use methods of mass appraisal of the commercial value of the real estate, constructed on the basis of econometric models. Application of such models will allow us to receive rather precise, authentic estimation of the commercial value of residential real estate in the conditions of dynamics of the Latvian market of real estate.
Evolutionary Trends of Romania’s Small and Medium-Sized Enterprises in the Present Context of the European Economy
Authors: Man Mariana , Macris Maria
Published: March 2022

The main objective of the hereby scientific approach represents the carrying out of an evaluation of the present condition of Romania’s small and medium - sized enterprises in the context of the economic terms imposed by the European environment that is strongly affected by the worldwide economic crisis. Accordingly, we have briefly analyzed the main demographic and economic indices that characterize the activity of small and medium - sizes enterprises; such indices may become the most important devices of the process of evaluating and founding the policies and programs of financial support targeting exactly such companies. The analysis displayed by the hereby research is grounded upon a series of official statistic data belonging to specialized institutions in our country.
The Concepts of Goodwill Accounting
Authors: Konečný Alois , Lemeshko Oleksandra , Sedláček Jaroslav
Published: March 2022

The paper “The concepts of goodwill accounting” analyzes and compares several problems arising from accounting techniques concerning goodwill according International Financial Reporting Standards or Generally Accepted Accounting Standards of the United States of America. It is concentrated on evaluation of the harmonization level between these two Standards and in cases where these standards differ it tries to suggest the better solution for the selected problem. At the beginning it is oriented on the definition of goodwill in both Standards that is unfortunately not very precisely stated. On the contrary the way of its value calculation is defined very well. In the next chapters is emphasized that there is precise differentiation between accounting for goodwill existing and/or acquired in course of entity`s ordinary business activity and the ones acquired in course of a business combination. And because this segregation is respected in the rest of this paper the accounting procedures concerning goodwill identification, useful life, amortization and connected values (carrying amount, recoverable amount, fair value and the amount of net consideration transferred) are studied from this points of view too. Last but one chapter is interested in impairment of goodwill and in the end there are particular gained knowledge generalized into final conclusions.
Evaluation of the relationship between dehydroepiandrosterone sulfate-total testosterone ratio and metabolic parameters in patients with polycystic ovary syndrome
Authors: ÖZ GÜL Özen , CANDER Soner
Published: March 2022

Objective: In this study we aimed to evaluate the correlations between dehydroepiandrosterone sulfate-total testosterone (DHEAS/TT) ratio and insulin resistance, glycemic and lipid parameters.

Methods: A total of 35 patients with polycystic ovary syndrome (PCOS) and 34 healthy volunteers were included in the study. Anthropometric, clinical, biochemical, lipid and glycemic measurements were performed according to routine standards. Patients’ demographic, clinical, anthropometric, biochemical, glycemic, lipid and hormonal parameters were measured and recorded. DHEAS/TT ratio was calculated in all patients. DHEAS/TT ratio and metabolic parameters were compared between the PCOS and control groups.

Results: There were significant differences between the PCOS and control groups in terms of fasting blood glucose, total cholesterol, high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), triglycerides, insulin and homeostatic model assessment-Insulin resistance (HOMA-IR) values (for all, p
Evaluation of sitagliptin therapy on the levels of fibroblast growth factor-19 (FGF19) in patients with Type 2 diabetes
Authors: ÖZ GÜL Özen , CANDER Soner
Published: March 2022

Introduction: The specific association between sitagliptin and Fibroblast Growth Factor-19 (FGF19) is yet to be clarified. In this study, we aimed to investigate the effect of sitagliptin therapy on the levels of FDF19 in patients with type 2 diabetes mellitus (T2DM).

Methods: A total of 35 patients newly diagnosed type 2 diabetes, and who had not received antidiabetic treatment before were included in this study. Sitagliptin therapy was administered as 100 mg/day. Patients’ demographic, anthropometric features, glycaemic variables, lipid profiles and FGF19 values were evaluated at the baseline and at the 3rd month of the treatment and the obtained data were compared.

Results: The mean age of the patients was 53.34 ± 8.09 years. The mean weight, body mass index (BMI), hip circumference, postprandial blood glucose and glycosylated haemoglobin A1c (HbA1c) values were statistically significantly lower at the 3rd month of the treatment compared to the baseline values (for all, p
Investigation of serum neprilysin levels in overweight and normal weight young women
Authors: CANDER Soner , ÖZ GÜL Özen
Published: March 2022

Background: In this study we aimed to evaluate biochemical, lipid and glycemic parameters and to compare serum neprilysin levels between overweight (OW) and normal weight (NW) young women who are more prone to gain weight.

Material and Methods: A total of 28 overweight/obese women aged between 22-34 years and 34 age matched normal-weight women were included in this cross-sectional study on voluntary basis. of the subjects were performed, Participants’ anthropometric measurements, hormone profiles, glycemic parameters and insulin resistance, and serum neprilysin levels were recorded and analyzed. Patients were evaluated in two groups as Group OW and Group NW.

Results: The mean ALT, TSH and uric acid values were statistically significantly higher in Group OW compared to Group NW (for all, p
Retrospective evaluation of microalbuminuria and GFR levels of diabetic patients taking DPP-4 Inhibitor, GLP-1 Analog, or SGLT-2 Inhibitor
Authors: GÜLTAŞ Bahriye , ÖZGÜL Özen , CANDER Soner
Published: March 2022

Background: In our study, we determined the changes in microalbuminuria and gfr (glomerular filtration rate) values, which are important for diabetic nephropathy, within 1 year after starting treatment in our patients taking DPP-4 inhibitor (linagliptin), GLP-1 analog (exenatide) and SGLT-2 inhibitor (empagliflozin).

Material and Methods: We evaluated the urea, creatinine, gfr and microalbuminuria levels of our patients who were treated with linagliptin, exenatide and empagliflozin on their 0th, 6th and 12th month visits. We included patients who were followed up for nephropathy for at least 1 year after starting treatment in each drug group.

Results: When the 0th and 12th month GFR values of our 98 patients who were prescribed linagliptin were compared, an increase of 4.57% was detected (p0.05). While no statistically significant difference was found in the 0th and 12th month GFR follow-ups of our 97 patients using exenatide (p>0.05); in this group, it was determined that the microalbuminuria decreased significantly in 12 months in 33 of our patients who could be followed up in terms of microalbuminuria (p0.05); however, it was determined that microalbuminuria decreased significantly at the end of 1 year in our 79 patients who could be followed up for microalbuminuria in this group (p
Evaluation of Insulinoma Cases Presented with Hyperinsulinemic Hypoglycemia: A single-centre Experience
Authors: AYDEMİR Ensar , ATEŞ Coşkun , MERCAN SARIDAŞ Filiz , HOCAOĞLU Erhan , CANDER Soner , ÖZ GÜL Özen , ERTÜRK Erdinç , ERSOY Canan
Published: March 2022

Introduction

Insulinomas constituting the most common cause of endogenous hyperinsulinism-related hypoglycemia are neuroendocrine tumors originating from pancreatic beta cells. They are generally benign and solitary lesions. Although most cases are sporadic, multiple endocrine neoplasia (MEN) 1-related patients are also present.

Material and Method

Thirteen patients followed up in Bursa Uludağ University Medical Faculty Endocrinology and Metabolic diseases clinic between the years 2012 and 2021 were retrospectively evaluated. Demographical, clinical, biochemical, radiological and histopathological data of the patients were assessed.

Results

Eight of the patients were females, and five were males with an average age of 43±14.9 years. Ten of the patients had sporadic, and three had MEN1 syndrome-related insulinoma. During the prolonged fasting test, the patients had a mean lowest plasma glucose level of 36.4 ± 6.2 mg/dl with a simultaneous mean insulin level of 11.3 (4.4 - 214.1) mIU/L and c-peptide level of 2.8 (0.46-12.8) mcg/L. In preoperative localization studies, a lesion was detected in 11 out of 13 (84.6%) patients with upper abdominal computed tomography (CT) and 6 out of 10 patients (60%) with magnetic resonance imaging (MRI). Six patients had grade 1, and 7 patients had grade 2 neuroendocrine tumor. The whole group's mean lesion diameter was 15 (11-48) mm. The mean patient follow-up duration was 30.5 ± 23 months. Hypoglycemia recurred in none of the patients in the postoperative period, and only two patients (15.4%) developed postoperative diabetes mellitus (DM).

Conclusion

Preoperative localization rates in insulinomas increased due to non-invasive imaging methods and technological developments in recent years. This will probably cause earlier diagnosis and treatment, and pancreas preserving surgery option will be more available in most insulinoma cases.
Evaluation of the Impact of COVID-19 on the Yearly Distribution of Brain Death Declarations in Turkey Between 2011 and 2020
Authors: ELGİN Ersin , SEZEN Mehmet , YİLDİZ Abdulmecit , ORUÇ Ayşegül , ÇİÇEK Mehmet Çağatay , GÜNSEVEN Kadir Ömür , SELİMOĞLU Kerem , OFLAZ Rafet , ERSOY Alparslan
Published: March 2022

The 2020 data of the Turkish Society of Nephrology reveals that the number of patients receiving hemodialysis and peritoneal dialysis treatment in Turkey is 63,945.1 According to the 2020 registered data of the Transplantation Dialysis Monitoring System (TDIS), the number of patients waiting for solid organs is 23,923. The number of organs used was 1,059 out of 1,391 brain death cases declared in 2020.2 While solid organ transplantation could be performed in 4.42% of the patients enrolled in TDIS, 95.58% could not. Insufficient organ supply in our country adversely affects patients waiting for organs. Our study aimed to investigate the effect of the COVID-19 pandemic on the distribution of brain deaths declared in our country by years.
Evaluation of the Effect of the COVID-19 Pandemic on the Distribution of Kidney Transplants in the World in 2019 and 2020
Authors: ELGİN Ersin , SEZEN Mehmet , YİLDİZ Abdulmecit , ORUÇ Ayşegül , GÜLLÜLÜ Saide , ÇİÇEK Mehmet Çağatay , GÜNSEVEN Kadir Ömür , SELİMOĞLU Kerem , OFLAZ Rafet , ERSOY Alparslan
Published: March 2022

Background: The COVID-19 pandemic caused by SARS-CoV-2 has had adverse effects in every field. One of the affected areas is organ supply and transplantation. This study aimed to evaluate the impact of the pandemic period on the number of kidney transplants in 2019 and 2020 in countries with a population of 40 million and above.

Material and Methods: We evaluated kidney transplants from living and deceased donors reported between 2019 and 2020 from the Global Observatory on Donation and Transplantation (GODT). We obtained the number of kidney transplants in countries with a population of 40 million and over before and after the COVID-19 pandemic.

Results: The total number of kidney transplants performed in 2019 and 2020 of countries with a population of 40 million or more, which sent data to the GODT database, were respectively: Sudan 313 and 139, Algeria 270 and 91, Argentina 1,675 and 854, Spain 3,423 and 2,702, Colombia 947 and 526, Republic of Korea 2,293 and 2,280, Italy 2,139 and 1,907, France 3,643 and 2,595, UK 3,649 and 2,567, Thailand 679 and 712, Germany 2,132 and 1,909, Iran 2,101 and 1,240, Turkey 3,863 and 2,498, Philippines 300 and 132, Ethiopia 35 and 8, Japan 1,913 and 1,697, Mexico 2,976 and 913, Russian Federation 1,473 and 1,124, Bangladesh 205 and 155, Nigeria 164 and 165, Pakistan 1,306 and 129, Brazil 6,298 and 4,830, United States 24,273 and 23,644, India 9,751 and 5,486, China 12,124 and 11,037.

Conclusions: Compared to 2019, deceased and living kidney transplants increased only in Thailand in 2020, while kidney transplants in other countries have decreased. Countries where deceased kidney transplants increased in 2020, were Thailand, Korea, and the United States. Total kidney transplants in Turkey decreased by 35.4% in 2020 compared to 2019.
Comparison of Clinical Data and Treatment Responses of Patients with Essential Thrombocythemia Using Anagrelide by JAK2 Gene Mutation Status
Authors: GÜLLÜ KOCA Tuba , ÖZKALEMKAŞ Fahir , OZKOCAMAN Vildan , ERSAL Tuba , ESENBUĞA Şeyma
Published: March 2022

Introduction: Essential Thrombocytemia (ET) is a clonal stem cell disease that manifests itself with proliferation in the megakaryocytic lineage in the bone marrow, with clinical presentations ranging from asymptomatic to bleeding and thrombosis spectrum.

In medical treatment, aspirin and/or monitoring are recommended for low-risk patients, while cytoreductive therapy is recommended for high-risk patients. Cytoreductive therapy is often used in patients with a very high platelet count (>1,000,000). The first choice in cytoreductive treatment is Hydroxyurea, and Anagrelid treatment is preferred in the young patient group and patients with hydroxyurea resistance/intolerance.

This study aimed to evaluate the effects of the JAK2 mutation, which is associated with high risk, in the patient group receiving anagrelide therapy.

Method: The files of patients diagnosed with ET according to 2016 WHO criteria and followed up under Anagrelide therapy in our center between January 2002 and December 2021 were reviewed retrospectively. In addition to the demographic data of the patients, diagnostic tests, bone marrow evaluations, JAK2 mutation status, and laboratory data were noted. Patients were divided into two groups according to JAK2 mutation positivity and negativity. The obtained data were compared between the two groups.

Results: Thirty-three patients (male/female: 20/13) treated with Anagrelide for the diagnosis of ET were included in the study. It was observed that 14 (42%) of the patients were positive for JAK2 mutation. There was no significant difference between the groups regarding age at diagnosis, gender, duration of anagrelide use, and bone marrow fibrosis degrees. When the laboratory tests were compared at the time of diagnosis, the WBC count was significantly higher in the JAK2 positive group; other series were similar. When the last control laboratory data of the patients were compared, WBC, neutrophil, and hemoglobin levels were observed to be significantly higher in JAK2 positive patients, while LDH levels were significantly lower.

Conclusion: It was observed that JAK2 mutation positivity, which is associated with high risk in ET risk staging, did not negatively affect anagrelide treatment response. In ET patients, leukocytosis (>11,000/mm3) has been identified as a risk factor for the whole lifespan. It was observed that the WBC counts of the patients who were positive for JAK2 were significantly higher at the time of diagnosis and during the treatment process. Since the LDH level after treatment is higher in patients with positive JAK2 mutation, it has been evaluated that JAK2 mutation may play a role in resistance to cytoreductive therapy.
La tecnología en la formación docente
Authors: Chiquini Charlotte Monserrat Llanes , Canul Carlos Alberto Pérez , Cortés Roger Manuel Patrón , Chuc Giselle Guillermo , Álvarez Diana Concepción Mex
Published: March 2022

Este proyecto surge de la necesidad de proponer acciones que promuevan el uso y apropiación de las TIC entre las personas que fungen como docentes en las instituciones de educación superior de nuestro país.  Para ello fue necesario obtener evidencias acerca del conocimiento que los profesores universitarios tienen de estas tecnologías y el modo en que hace uso de ellas, si es que las usan, pues existen algunos indicios que apuntan en el sentido de que no todos los profesores aprovechan las posibilidades que las TIC brindan como herramienta en la formación profesional de los alumnos.  Sin duda, un mejor conocimiento y uso de las TIC por parte de los profesores potencia las posibilidades de mejorar la calidad de la enseñanza, elemento sine qua non podremos ingresar como país en la sociedad del conocimiento; no cabe duda de que México deberá enfocar sus esfuerzos en esa dirección.
A technical and economic evaluation of supplemental feeding strategies for Nile tilapia (Oreochromis niloticus L.) reared in lake-based cages
Authors: Romana-Eguia Maria R.R. , Samoranos Mark N. , Aya Frolan A. , Alava Veronica R. , Salayo Nerissa D.
Published: March 2022

Tilapia cage farming in eutrophic lakes uses low stocking densities since tilapias can thrive mainly on natural food or minimal supplementary feeding. For semi-intensive Nile tilapia cage culture, feeding strategies to improve productivity are adopted based on technical viability and cost efficiency, as assessed in the present study. Tilapia fingerlings stocked in triplicate cages per treatment were reared in Laguna de Bay, Philippines for five months, one run each during the dry and wet seasons. The treatments were: I – UNFED or no feeding; II - FED, fish fed for the entire 155 days; III - D45, fish fed from day 45 to harvest; and IV - D75, or fish fed from day 75 to harvest. Average weight gain or AWG (153.18 g and 225.85g, for dry and wet seasons, respectively) were highest in FED. Growth parameters in all fed treatments were significantly higher (p<0.05) than in UNFED for both seasons. Survival rates were higher during the wet season (66-70%) compared to the dry season (35-37%). Moreover, in the wet season, when the lake’s primary productivity is low, full feeding can be done without compromising lake water quality. Results showed that it favored high AWG, survival, reasonable market price, and profit.
Diet high in α-linolenic acid up-regulates fatty acids biosynthesis-relate gene expression in the hepatopancreas of Yellow River carp (Cyprinus carpio)
Authors: Ren Hong-tao , Zhang Xiao nan , Wang Qi zheng , Duan Sheng hui
Published: March 2022

Little information on the effects of a high α-linolenic acid (C18:3n-3) diet on fatty acid composition and lipid-producing gene expression in the hepatopancreas from Yellow River carp (Cyprinus carpio). In the study, 60 common carp juveniles were fed for 50 days, a high α-linolenic acid diet supplemented with linseed oil (LO), and a control diet without the addition of

linseed oil to evaluate the effect on lipid composition and gene expression of peroxisome proliferator-activated receptors (PPAR-α), delta-6 fatty acid desaturase (delta-6-Fad), stearoyl-CoA-desaturase (SCD), and fatty acid desaturase-5 (Elovl5) in the hepatopancreas. The results showed that increased levels of C20:4n-6, C18:3n-3, C20:5n-3, and C22:5n-3 were observed in LO treated Yellow River carp hepatopancreas. PPAR-α, delta-6-Fad and Elovl5 gene expression was up-regulated in the Yellow River carp’s hepatopancreas fed with a high α-linolenic acid diet (P < 0.05), while SCD gene was down-regulated. In conclusion, the addition of α-linolenic acid to the Yellow River carp diet affected gene expression (SCD, PPAR, delta-6-Fad, and Elov15) involved in regulating fatty acid (FA) profile Yellow River carp. It is suggested that delta-6-Fad, Elovl5, and PPAR-α be essential messengers responsible for translating nutritional

stimuli into gene expression changes in the hepatopancreas.
THE MEDICOLEGAL VIEW OF THE RAINS AND LANDSLIDES IN THE SERRANA REGION OF RIO DE JANEIRO: A LITERATURE REVIEW
Authors: Moura Julia , Paiva Laura , Jardim Letícia , Magalhaes Lohana , Reis Luiza , Silva Mayume
Published: March 2022

Introduction: The article is a literature review that aims to analyze, from the perspective of Legal Medicine, the consequences of rains and landslides in the Serrana region of Rio de Janeiro in 2011, with an emphasis on the work of medical examiners with regard to medical expertise in large-scale disasters. Method:  The bibliographic databases used to search the National Library of Medicine (PUBMED) and Scientific Electronic Library Online (SCIELO), in addition to manuals, magazines, and a literature listed in the Fundamentals of Legal Medicine by Genival Veloso de França. All the selected bibliography was published between the years 2008 to 2022. Conclusão: After the discussion and analysis of the data, it was possible to conclude that in calamitous events, sudden and of harmful proportions, it is essential that the process of identification of the human bodies be carried out by a qualified team of medical experts, followed by scientific forensic identification criterion, thus avoiding inaccuracies in this process.
Implementasi Metode Montessori Dalam Berbagai Bidang Studi: Pengenalan dan Pelatihan Metode Montessori Bagi Guru dan Tenaga Kependidikan di SD Muhammadiyah Pahandut Palangka Raya
Authors: Usop Dwi Sari , Sari Rospala Hanisah Yukti , Isnaeni Marhani  , Istiqamah Hafid
Published: March 2022

The 2019 coronavirus (Covid-19) pandemic in Indonesia has decreased. Some schools have started holding face-to-face meetings with students. Some schools are still doing distance learning (online). Many problems are found in online learning, such as the lack of attention of students and lack of understanding of students understanding the material presented by the teacher. Therefore, it is necessary to use learning methods that can attract the interest and attention of students in distance learning (online). One of the learning methods is the Montessori method. The use of the Montessori method is considered to be able to provide a different atmosphere for students in the learning process. In fact, there are still teachers in schools who are not familiar with the Montessori method The use of the Montessori method is considered to be able to provide a different atmosphere for students in the learning process. In fact, there are still teachers in schools who are not familiar with the Montessori method so that they need to be introduced and given special training so that knowledge insights are developed and can be practiced during daily learning
Pemanfaatan Aplikasi Google Formulir Sebagai Sistem Informasi Untuk Pendataan Pada Kader PKK Kelurahan Ragunan Jakarta Selatan
Authors: Eko Eko Setia Budi , Abdul Rahman Kadafi  , Eva Zuraidah  , Chaerul Bachri  , Ipin Sugiyarto  , Fitriyani Pramitasari  , Afika Kurnia Dewi  , Ade Sutrisna  , Mochammad Randika  , Budi Setiyanto
Published: March 2022

Karang Taruna is a social organization as a forum and means of developing every member of the community that grows and develops on the basis of awareness and social responsibility from and for the community, especially the younger generation in the region, especially engaged in social welfare efforts. Meanwhile, Karang Taruna membership, hereinafter referred to as Karang Taruna Community, is every member of the community aged 13 (thirteen) years to 45 (forty five) years who resides in the village/kelurahan. Limited understanding of the management of Google Formulas for data collection information systems in the PKK Cadre, Ragunan Village, South Jakarta. Therefore, Nusa Mandiri University carried out Community Service in the form of training on the Use of Google Form Applications at the PKK Cadre of Ragunan Village in South Jakarta. With this training, it can help PKK cadres in Ragunan, South Jakarta in using the Google Form application. After the group is formed, one person is appointed who has the responsibility as chairman. This socialization aims to introduce one of the google doc facilities, namely the google form which can facilitate reporting of activities that have been carried out by the dasawisma of Ragunan village. The result of the implementation of this community service activity is that participants in the activity acquire new knowledge in using Google Forms