bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficiency based updating of evidence based surgical guidelines - Experiences from a multidisciplinary guideline upon Minimally Invasive Surgery
Authors: Tummers F.H.M.P. , Coppus S.F.P.J. , Lagerveld B.W. , Demirkiran A , van Schrojenstein Lantman E.S. , Brouwer T.A. , Draaisma W.A. , Jansen F.W.
Published: September 2023

Background: Updating evidence-based clinical practice guidelines is an onerous process and there is a call for more efficient determination of key questions that need updating. Especially for surgical techniques it is unclear if new evidence will result in substantial changes after wide implementation and if continuous updating is always necessary.

Objectives: This study analyses the impact of updating a surgical guideline and proposes suggestions for optimising this process.

Materials and methods: The Dutch Minimally Invasive Surgery guideline was developed in 2011 and updated in 2021. For both versions a multidisciplinary guideline working group (GDG) was created, that determined key questions. Changes in conclusions and recommendations were analysed by the GDG and statements for expected change of recommendations in the future were made.

Results: 15 key questions were formed, of which 12 were updates of the previous guideline. For only 27% of the updated key questions, the conclusions changed. In ten years, the body grew only marginally for most key questions and quality of the evidence did not improve substantially for almost all key questions. However, in this first update of the MIC guideline, many recommendations did change due to a more robust interpretation of the conclusions by the GDG. Based on analysis of this updating process, the GDG expects that only four out of 15 recommendations may change in the future.

Conclusion: We propose an additional step at the end of guideline development and updating, where the necessity for updating in the future is determined for each key question by the GDG, using their valuable knowledge gained from developing or updating the guideline. For surgical guidelines, the authors suggest updating key issues if it includes a relatively newly introduced surgical- or adapted technique or a new patient group. Low quality or small body of evidence should not be a reason in itself for updating, as this mostly does not lead to new evidence-based conclusions. This new step is expected to result in a more efficient prioritising of key questions that need updating.

What’s new? By adding one additional step at the end of the updating process, the future updating process could become more efficient.
A proof of concept that experience-based management of endometriosis can complement evidence-based guidelines
Authors: Wattiez A , Schindler L , Ussia A , Campo R , Keckstein J , Grimbizis G , Exacoustos C , Kondo W , Nezhat C , Canis M , De Wilde R.L. , Miller C , Fazel A , Rabischong B , Graziottin A , Koninckx P.R.
Published: September 2023

Background: Management of endometriosis should be based on the best available evidence. The pyramid of evidence reflects unbiased observations analysed with traditional statistics. Evidence-based medicine (EBM) is the clinical interpretation of these data by experts. Unfortunately, traditional statistical inference can refute but cannot confirm a hypothesis and clinical experience is considered a personal opinion.

Objectives: A proof of concept to document clinical experience by considering each diagnosis and treatment as an experiment with an outcome, which is used to update subsequent management.

Materials and Methods: Experience and knowledge-based questions were answered on a 0 to 10 visual analogue scale (VAS) by surgery-oriented clinicians with experience of > 50 surgeries for endometriosis.

Results: The answers reflect the collective clinical experience of managing >10.000 women with endometriosis. Experience-based management was overall comparable as approved by >75% of answers rated ≥ 8/10 VAS. Knowledge-based management was more variable, reflecting debated issues and differences between experts and non-experts.

Conclusions: The collective experience-based management of those with endometriosis is similar for surgery-oriented clinicians. Results do not conflict with EBM and are a Bayesian prior, to be confirmed, refuted or updated by further observations.

What is new? Collective experience-based management can be measured and is more than a personal opinion. This might extend EBM trial results to the entire population and add data difficult to obtain in RCTs, such as many aspects of surgery.
“All that has room within it / even without / language”: the poetic technique of Paul Celan
Authors: Webster Mags
Published: September 2023

The eastern European poet Paul Celan (1920–70) asserted that poetry is non-aesthetic: neither a work nor a process of art. His uncompromising approach, which became increasingly concerned with language’s capacity not only to broach the unspeakable, but also bring that unspeakability into his poems, continues to influence and shape the work of contemporary scholars, translators and poets. In this paper, I use apophasis – a centuries-old philosophical and rhetorical approach developed to deal in language with what lies beyond language – as a lens through which to examine Celan’s extraordinary relationship with and handling of words; and how he manages to shave language to its sheerest extremes. I investigate his diction and register, his wrenching and deforming of the German tongue, his inventive reworking of selected vocabulary into neologism, and the effect of this compressed energy on the structure and tone of the poems. Arguing that Celan achieves a verbal and dynamic dislocation that draws attention to what the poems stop short of saying, I consider what might usefully be drawn from his radical example, in order to shape a contemporary poetics whereby a poet might deal with what can be said against the mightiness of what cannot
Poetry’s upper limit
Authors: Garnier Etienne
Published: September 2023

Louis Zukofsky’s poetic work has always been noted for its difficulty. Throughout his career, he kept in mind the principles created by Ezra Pound, and he made music the focus of his poems. This focus is all the more visible in his major work “A”. Composed of 24 movements, “A” is the culmination of its author’s capabilities. There, Zukofsky famously expressed his poetic views using the integral

speech

∫

music

where speech and music are the limits defining the interval in which poetry is bound. “A”-24, the poem’s last movement, is an illustration of Zukofsky’s will to create a musical poetry. Written with the help of his wife, Celia, and otherwise titled L.Z. Masque, the poem is composed of four different lines of text, all quotations from works by Zukofsky. Marked T for thoughts, D for Drama, S for story, P for poetry, Zukofsky’s different works are there set to music, using Handel’s Harpsichord Pieces. The superimposition of these different works leads to a shift in the perception of the poetic work. In this radical challenge to the practice of reading, Zukofsky’s movement pushes poetry to the limit, one that needs to be questioned.
Seeing the pen as a bayonet: The extremities of Vladimir Mayakovsky’s utopian imagination
Authors: Markovic Mark
Published: September 2023

When examined retrospectively, some poetry can be seen as using scandal and rebellion to defy social norms. Vladimir Mayakovsky’s poetry criticised the repression and conservatism ingrained in the fabric of Tsarist Russia; a society defined by bourgeois, capitalistic and heteronormative values. As a passionate Bolshevik, the alienation induced by the restrictive external world caused Mayakovsky to use poetry for its most extreme, subversive means in inciting revolution. While viewing Mayakovsky as a political voice for the proletariat is a commonly held view, an often overlooked aspect is how poetry was used to convey his sexual expression. When considered amidst the repressive views on sexuality that were characteristic of both Tsarist and even Soviet Russia, the flamboyant poet was consistently prone to controversy.
“Tomar Santan Jano Thake Dudhe-Bhaate”: Exploring the Naxal movement through Bengali protest poetry
Authors: Dasgupta Shriya
Published: September 2023

The Naxalite Movement was a radical left wing extremist movement that started in 1969 in the Indian state of West Bengal. Inspired by the ideas of Mao Tse Tsung, the combatants engaged in guerrilla warfare aiming to capture state power through armed insurgency, “annihilation line” that included the assassination of the representatives of the state administration and mass mobilisation. In the early 1970s, Calcutta, the capital of West Bengal, witnessed large-scale student participation in the conflict. It was suppressed by the State through the Operation Steeplechase, brutal police repression including widespread human rights violations.

No political movement in post-independent India spawned as much literature, ranging from poetry to autobiographical narratives, as the Naxal Movement. Through a qualitative study, this paper attempts a critical analysis of the representative artistic expression by the Naxalites during the first phase of the conflict between 1969 and 1975. Drawing upon the poetry of revolutionaries such as Dronacharya Ghosh, Saroj Dutta and Timir Baran Sen, all of whom were killed by the police, along with the works of Naxal sympathiser poets like Sankha Ghosh and Birendranath Chattopadhyay, this paper aims to fill the research gap that exists in academia in the sphere of literary representation by the Naxal combatants.
Creative companionship as we face the apocalypse – an essay in conversation
Authors: Cosgrove Shady , Howe Christine
Published: September 2023

This essay explores how a commitment to poetic collaboration, with daily writing and reading, changed the ways we perceived and lived our lives, particularly in light of living through the extremity of climate change (characterised by Australian bush fires and floods), and the isolation and stress caused by the pandemic. We explore collaboration, prose poetry and the creative process in the context of extremity, arguing that writerly collaboration can engender hope beyond the page. We discuss these topics in an essay-conversation format, moving back and forth between authors, building/ expanding/thinking and re-thinking through matters of process in light of the poetic and the extreme. Some of our creative works from this time are also included.
“Trace your grave”: On the poetry of The Communist Manifesto’s grave-digger thesis
Authors: Althofer Jayson
Published: September 2023

The Communist Manifesto (1848) was written by two erstwhile poets, Karl Marx and Friedrich Engels, who dedicated themselves to working-class self-emancipation, which requires the forcible overthrow of capitalist society. Poetry vitalised their revolutionary politics and impelled them beyond poetry to critico-practical class struggle against the bourgeoisie. Using Samuel Moore’s 1888 English translation, which Engels assisted and authorised, this paper presents new readings of famous images and passages in the Manifesto by demonstrating the significance of poetry to its representation of working life and living-dead extremity in bourgeois society. It focuses on the poetry of the Manifesto’s thesis that the bourgeoisie produces its own grave-diggers. Marx and Engels wove poetry into their thesis, including blank verse by Shakespeare and works by Johann Wolfgang von Goethe, Percy Bysshe Shelley, Thomas Hood and Heinrich Heine. The paper addresses Marx and Engels’s critical assimilation of one poem in particular: Shelley’s “Song to the Men of England” (1819). It also regards, through poetry, their critique of the extremity of capital – its infinity – which necessitates proletarian revolution for human liberation. The coda posits the Manifesto as a “barricade-poem” in prose form.
Poetry and precarious memory: Ways of understanding less and less
Authors: Hetherington Paul , Atherton Cassandra
Published: September 2023

Poetry as an art form has traditionally registered tropes of feeling and memory, often with astonishing power, especially since the Romantics began to focus on projections of the self. Yet, when poetry invokes memory, anchoring people to their pasts and identities, it frequently reveals that, at best, memory offers a precarious connection to what is certain or secure – and this is particularly the case for women writers. For example, much of Emily Dickinson’s poetry reveals that memory’s recesses are often uncomfortable, and studies in autobiographical memory confirm poetry’s intuition that all may not be what it seems within the “house” of the recollecting self. This paper explores ways in which poetry’s elusive suggestiveness, and memory’s more fraught instances, confirm the provisionality and precarity of what most people are inclined to take for granted – that they know themselves and can speak securely of who they are. This has always been a challenge for women in patriarchal societies as gender inequality and precarious work – often in atypical employment – has informed and affected their expressions of self and identity. We conclude with examples from the work of two contemporary women poets, Emma Hyche and Mary A. Koncel, in order to focus on their particular approaches to precarity in their poetry and prose poetry and to posit that women poets often disrupt and disturb aspects of the patriarchal language system to offer new constructions of autobiographical memory.
Escisiones. Hacia una noción impolítica de decisión en Massimo Cacciari
Authors: Bialakowsky Guillermo
Published: September 2023

En el presente trabajo examinaremos la relevancia de la categoría de decisión en el surgimiento del pensamiento impolítico contemporáneo en Italia. Con este objetivo, buscaremos elaborar una exégesis del rol de dicha noción en los desarrollos de Massimo Cacciari de finales de la década de 1970. Nuestro punto de partida se encontrará en su lectura nietzscheana sobre el diagnóstico de crisis de las categorías metafísicas y políticas tradicionales. Tal interpretación nos conducirá a estudiar su análisis de la soberanía desde una “concepción criatural” del orden político. En este sentido, sostendremos que la crítica que Cacciari realiza al concepto de decisión no sólo vertebra desde sus inicios al horizonte impolítico, sino que también nos permite comprender los alcances filosóficos de su perspectiva.
Changes in Autonomic Nervous System Activity in Children With Spina Bifida: A Case-Control Study
Authors: Kim Byeong Seon , Franco Israel , Lee Yong Seung , Han Sang Won , Kim Sang Woon
Published: September 2023

Purpose: We compared heart rate variability parameters between patients with spina bifida and a control group during urodynamic studies, with the goal of evaluating the autonomic nervous system dysfunction present in spina bifida.Methods: Continuous heart rate variability parameters were recorded during 3 successive periods (P0, the 2 minutes prior to the start of filling; P1, from the start of filling to the first desire to void; and P2, from P1 to the end of filling or the start of voiding). The control group consisted of children with vesicoureteral reflux who had undergone video-urodynamic studies. Our study included 11 patients with spina bifida and 9 control participants.Results: At baseline, patients with spina bifida exhibited lower values for the root mean square of successive differences in NN intervals, the percentage of successive R-R interval differences exceeding 50 msec relative to the total number of intervals, and high frequency (HF). In contrast, the low frequency (LF)/HF ratio was elevated in these patients (5.04 ± 4.75 vs. 0.67 ± 0.42, P = 0.014). During bladder filling, LF/HF values increased in the control group (P0, 0.67 ± 0.42; P1, 0.89 ± 0.34; P2, 1.21 ± 0.64; P = 0.018), while they declined in patients with spina bifida (P0, 5.04 ± 4.75; P1, 3.96 ± 4.35; P2, 3.26 ± 4.03; P < 0.001). The HF values were significantly elevated in children with spina bifida during bladder filling (P = 0.002). In the time domain, the standard deviations of all NN intervals were elevated only in the control group during bladder filling. Parasympathetic activity domains were reduced in the children with spina bifida at the initial assessment.Conclusions: During the bladder filling phase, parasympathetic activity increased along with fixed sympathetic activity in the spina bifida group. In contrast, the control group exhibited a shift towards a sympathetic preponderance at the conclusion of bladder filling. These observations may be associated with the pathophysiology of neurogenic bladder in spina bifida.
Differentially Expressed mRNA in Streptozotocin-Induced Diabetic Bladder Using RNA Sequencing Analysis
Authors: Kim Jae Heon , Yang Hee Jo , Lee Hong J. , Song Yun Seob
Published: September 2023

Purpose: To detect elements governing the pathogenesis of diabetic cystopathy (DC), mRNA sequencing was carried out for bladder tissues from normal rats and those with induced diabetes mellitus (DM). This research therefore offers possible underlying molecular pathways for the advancement of DC in relation to differential mRNA expression, together with visceral functional and architectural alterations noted in individuals with this condition.Methods: An intraperitoneal injection of streptozotocin (STZ) was utilized to provoke DM in male Sprague-Dawley rats. Dysregulation and significant variations between normal rats and those with induced DM were then identified by a fold change of ≥ 1.5 with a false discovery rate P < 0.05. Hierarchical clustering/heat map and Gene Ontology/DAVID reference sources were generated. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and protein-protein interaction analysis were then performed.Results: The diabetic rodent group exhibited a greater residual urine volume (4.0 ± 0.4 mL) than their control counterparts (0.7 ± 0.2 mL, P < 0.01) at 12 weeks after diagnosis of diabetes. Expression analysis revealed 16 upregulated and 4 downregulated genes in STZDM bladder samples. A notable increase in expression was seen in PTHLH, TNFAIP6, PRC1, MAPK10, LOC686120, CASQ2, ACTG2, PDLIM3, FCHSD1, DBN1, NKD2, PDLIM7, ATF4, RBPMS2, ITGB1 and HSPB8. A notable decrease in expression was seen in SREBLF1, PBGFR1, PBLD1 and CELF1. Major genetic themes associated with mRNA upregulation and downregulation ware identified via Gene Ontology analysis and KEGG pathways. Protein to protein interaction analysis detected PDLIM3, PDLIM7, ITGB1, ACTG2 as core high frequency nodes within the network.Conclusions: Changes in mRNA expression together with biological process and pathways that contribute to the etiologies underlying visceral impairment of the bladder in DM are evident. Our strategy is promising for recognizing mRNAs exclusive to the bladder in DM that might offer useful targets for diagnosis and treatment.
Transcutaneous Electrical Stimulation of the Abdomen, Ear, and Tibial Nerve Modulates Bladder Contraction in a Rat Detrusor Overactivity Model: A Pilot Study
Authors: Coolen Rosa L. , Frings Dennis , Asselt Els van , Scheepe Jeroen R. , Blok Bertil F. M.
Published: September 2023

Purpose: The global prevalence of overactive bladder (OAB) is estimated at 11.8%. Despite existing treatment options such as sacral neuromodulation, a substantial number of patients remain untreated. One potential alternative is noninvasive transcutaneous electrical stimulation. This form of stimulation does not necessitate the implantation of an electrode, thereby eliminating the need for highly skilled surgeons, expensive implantable devices, or regular hospital visits. We hypothesized that alternative neural pathways can impact bladder contraction.Methods: In this pilot study, we conducted transcutaneous electrical stimulation of the abdominal wall (T6-L1), the ear (vagus nerve), and the ankle (tibial nerve) of 3 anesthetized female Sprague-Dawley rats. Stimulation was administered within a range of 20 Hz to 20 kHz, and its impact on intravesical pressure was measured. We focused on 3 primary outcomes related to intravesical pressure: (1) the pressure change from the onset of a contraction to its peak, (2) the average duration of contraction, and (3) the number of contractions within a specified timeframe. These measurements were taken while the bladder was filled with either saline or acetic acid (serving as a model for OAB).Results: Transcutaneous stimulation of the abdominal wall, ear, and ankle at a frequency of 20 Hz decreased the number of bladder contractions during infusion with acetic acid. As revealed by a comparison of various stimulation frequencies of the tibial nerve during bladder infusion with acetic acid, the duration of contraction was significantly shorter during stimulation at 1 kHz and 3 kHz relative to stimulation at 20 Hz (P = 0.025 and P = 0.044, respectively).Conclusions: The application of transcutaneous electrical stimulation to the abdominal wall, ear, and tibial nerve could provide less invasive and more cost-effective treatment options for OAB relative to percutaneous tibial nerve stimulation and sacral neuromodulation. A follow-up study involving a larger sample size is recommended.
ANALYSIS OF INTELLECTUAL PROPERTY RIGHTS (IPRS) AND THEIR EFFECT ON SMALL & MEDIUM ENTERPRISES (SMES) WITH REFERENCE TO CHINA, PAKISTAN AND INDIA
Authors: Muhammad Waqas Gujjar Dr. Kashif Imran Zadi, Hafiz Muhammad Salman Shafiq,
Published: September 2023

Innovation and creativity are always fueled by intellectual property rights (IPRs) which is directly related to legal system of any country. It also boosts your competitiveness and generates new jobs. When utilized by others, the creativity of authors, architects, explorers, and many other IPR consumers is protected and benefited by IPR. Inventions, designs, developments, and literary works are all protected by intellectual property rights (IPRs). Besides, both developing and developed countries face significant difficulties when it comes to preserving copyrighted material. Most nations have separate laws in place to safeguard their rights to intellectual property. Although there are some significant differences among China, India and Pakistan's judicial systems for protecting intellectual property but still are relatively comparable to those of advanced economies. The examination of intellectual property rights protection in China, India and Pakistan is indeed the goal of this academic research. The policies governing IPR protection in these are also discussed in this study. In order to illustrate and explain the variations in IPR safety evaluations, this paper also launches a comparative analysis of international IPR rankings. The numerous elements that affect the inadequate preservation of property and intellectual property rights in these countries are also listed and discussed in this paper.
CONCEPTUAL ANALYSIS OF DELIBERATIVE DEMOCRACY: A SARTORIAN PERSPECTIVE
Authors: Dr. Irfan Muhammad, Dr. Abdul Khaliq Aboya
Published: September 2023

This paper attempts to analyze the concept of deliberative democracy by using Giovanni Sartori’s methodological framework. Sartori’s approach to concept analysis can be used to understand the concept of deliberative democracy in contemporary political theory. Because of the overwhelming literature on the concept of democracy, we don’t have unambiguous meanings of deliberative democracy which one can use in comparative political discourses and methods. The aim of this paper is to disambiguate and clarify the concept of deliberative democracy with the help of Sartori’s approach to concept formation and analysis. Conceptualization, Sartori argues, is intrinsically a qualitative exercise that is indispensable not merely for the intelligibility of empirical data but also for the meaningful rigorous research activity in social sciences. Furthermore, theorizing is only possible when we are clear about the concepts involved in the theory.
PATHOMORPHOLOGICAL CHANGES IN FIRST-CALF HEIFERS IN CASE OF ASSOCIATIVE COURSE OF THE DISEASE CAUSED BY HEMOLYTIC STRAIN OF E. COLI AND BOVINE HERPES VIRUS 1
Authors:   Don State Agrarian University, Mironova A.A. , Mironova L.P. ,   Don State Agrarian University, Khamidullin T.Sh. ,   Don State Agrarian University, Sidorenko N.G. ,   Don State Agrarian University, Pavlenko O.B. ,   Voronezh State Agricultural University named after Emperor Peter the Great, Manzhurina O.A. ,   FSBSI All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy
Published: September 2023

The associative course of the disease in heifers, caused by the hemolytic strain of E. coli and bovine herpes virus 1, is manifested by abortion and stillbirth. In all first-calf heifers, the retained placenta and necrotic metritis are recorded; 80.0% of the first-calf heifers die within a month after an abortion or a still-born fetus. At necropsy, the following pathoanatomical changes were detected, indicating a septic course of infection: necrotic metritis, hemorrhagic diathesis; right ventricular myocardial atrophy, acute alterative myocarditis; catarrhal-hemorrhagic cholecystitis; alterative hepatitis; fibrinous perihepatitis; acute catarrhal bronchopneumonia; hemorrhagic lymphadenitis; serous-fibrinous adhesive peritonitis; catarrhal-hemorrhagic enterocolitis; necrotic splenitis, fibrinous perisplenitis; hemorrhagic-necrotic nephritis.
Pedagogical works of K.D. Ushinsky and their importance for the development of medical education (to the 200th anniversary of the birth of the great Russian teacher)
Authors:   FGBU ", Shalygin L.D. ,   National Medical and Surgical Center them. N.I. Pirogov, Moscow, Loginov A.F. ,   FGBU "National Medical and Surgical Center them. N.I. Pirogov, Moscow, Tseev Yu.K. ,   Medical Institute FGBOU VO "MGTU", Maykop
Published: September 2023

The article describes the educational, research, pedagogical, writing and social activities of the outstanding Russian teacher Konstantin Dmitrievich Ushinsky. His significant contribution to the foundation and development of scientific pedagogy in Russia, reformation in the educational process, education, thinking, pedagogy, as well as innovation in literary and social activities is noted. The importance of K.D. Ushinsky's pedagogical works for the development of medical education, including in the IU of the Pirogov Center, is presented.
PROBABLE MECHANISM OF INFLUENCE OF HUMIC SUBSTANCES ON THE PRODUCTION PROCESS OF GREEN PLANTS
Authors:   Saint Petersburg State University, Popov A.I. , Zelenkov V.N. ,   All-Russian Scientific Research Institute of Vegetable Growing –  The Branch of FSBSI, Federal Scientific Center of Vegetable Growing,   All-Russian Research Institute of Medicinal and Aromatic Plants, Teplyakova T.V. ,   State Research Center of Virology  and Biotechnology “Vector”, Markov M.V. ,   Moscow State Pedagogical University
Published: September 2023

Humic substances, being, in fact, black liquor (a product of alkaline hydrolysis of organic matter of natural objects) and are a complex mixture of various organic compounds. They are able to accelerate the circulation of nutrients within plants, increase the permeability of cell membranes, exhibit detoxological properties, optimize the ratio of organic and mineral anions in plants, use some organic components of humic substances as nutrients in plant nutrition and induce the induction of gene expression.
ИССЛЕДОВАНИЕ ТЕОРЕТИЧЕСКИХ ОСНОВ И ПРАКТИЧЕСКИХ ОСОБЕННОСТЕЙ БЕЗОПАСНОГО ХРАНЕНИЯ ПИЩЕВЫХ ПРОДУКТОВ
Authors: Вербицкий Сергей , Куць А , Козаченко О , Пацера Н
Published: September 2023

Проанализирована теория и практика определения и научно обоснованного прогнозирования порчи, а также сохранения/потери питательной ценности, основных групп пищевых продуктов в процессе их хранения в соответствии с современными требованиями пищевой безопасности и ресурсосбережения. Установлено, что для динамического определения срока годности продуктов необходимо учитывать следующие факторы: внутренние (физические, химические, биохимические и микробиологические загрязнения), внешние (климат, экология, методы ведения сельского хозяйства, условия хранения и реализации, а также взаимодействие с людьми). Кинетику потери качества использовали как характеристику факторов, действующих при хранении и реализации продукции. Они включают модели жизненного цикла микроорганизмов (микробиологический прогноз), физические характеристики (например, текстура и цвет) и химические/биохимические параметры, влияющие на факторы питания и токсикологические факторы. Основные процессы порчи пищевых продуктов можно разделить на физические (структурно-механические), химические и микробиологические. Между ними существует корреляционная связь и в большинстве случаев наблюдаются все три вида порчи. Они связаны между собой по законам нелинейной зависимости и влияют друг на друга. При хранении пищевых продуктов существует несколько основных факторов, влияющих на длительность хранения и определяющих вид порчи: температуру, pH, активность воды, наличие кислорода, интенсивность светового потока, разнообразие и свойства ингредиентов, а также продуктов их распада. Математические модели прогнозирования способности продуктов хранения часто интегрированы в более общие модели качества пищевых продуктов. Модели показателей качества позволяют понимать, прогнозировать и контролировать процессы в течение периода хранения и реализации пищевых продуктов.
Relationship between Airline Ticket Price, Demand and Business Model: A Worldwide Analysis
Authors: KAYHAN Selçuk , KİRACI Kasım , YAŞAR Mehmet
Published: September 2023

The aim of this study is to reveal the relationship between the average price per passenger and the number of passenger of airlines. In the study, we analyzed the average price per passenger and number of passenger data of airlines for the period 2013-2022 using panel data analysis. We applied a panel regression model in the sample of all airlines. Therefore, we conducted the analysis using 4194 observations in the sample of all airlines. In addition, in the study, we divided the airlines into different groups according to their business model. In this context, we have classified airlines as Network carriers, Low-cost carriers, Charter carriers and Regional carriers. The findings of the study show that there is a reaction in the number of passengers against the change in the average price per passenger. The results of the analysis revealed that there is a significant and negative relationship between ticket price and airline demand but there are elasticity differences according to the business model.
Kết quả điều trị chảy máu não tại 8 Bệnh viện thuộc khu vực miền Bắc - Bắc Trung bộ Việt Nam
Authors: Tôn Mai Duy , Phương Đào Việt
Published: September 2023

Mục tiêu của nghiên cứu nhằm mô tả đặc điểm lâm sàng, kết quả điều trị và chỉ ra các yếu tố ảnh hưởng đến mRS 0-2 và tử vong sau 90 ngày điều trị ở các bệnh nhân chảy máu não tại các trung tâm/đơn vị/khoa đột quỵ ở miền Bắc và Bắc Trung bộ, Việt Nam. Nghiên cứu mô tả tiến cứu đa trung tâm trên 433 bệnh nhân từ 01/08/2022 đến 31/08/2022 được chẩn đoán chảy máu não tại 8 trung tâm điều trị đột quỵ. Kết quả nghiên cứu cho thấy độ tuổi trung bình của bệnh nhân là 60,71 ± 15,41. Số lượng bệnh nhân từ 45 tuổi trở xuống chiếm 13,8%, trong đó nam giới chiếm 66,1%. Số lượng bệnh nhân nhập viện tại trung tâm đột quỵ Bệnh viện Bạch Mai chiếm tỉ lệ lớn nhất với 56,4%. Sau 90 ngày điều trị, tỉ lệ bệnh nhân đột quỵ chảy máu não tử vong là 21%, tỉ lệ bệnh nhân mRS 0-2 là 46%. Điểm NIHSS và vị trí chảy máu là những yếu tố ảnh hưởng đến tỉ lệ tử vong và mRS 0-2 sau 90 ngày điều trị.
Ảnh hưởng của tần suất xuất tinh đến một số chỉ số tinh dịch đồ
Authors: Bắc Nguyễn Hoài , Dương Đinh Xuân
Published: September 2023

Tinh dịch đồ là một xét nghiệm quan trọng trong đánh giá khả năng sinh sản ở nam giới. Mối liên quan giữa tần suất xuất tinh và các chỉ số tinh dịch đồ vẫn còn nhiều tranh cãi. Vì vậy, chúng tôi tiến hành nghiên cứu này nhằm đánh giá: Ảnh hưởng của tần suất xuất tinh đến một số chỉ số tinh dịch đồ. Nghiên cứu được tiến hành trên 5506 nam giới đến kiểm tra sức khỏe sinh sản tại Bệnh viện Đại học Y Hà Nội. Tuổi trung bình của đối tượng nghiên cứu là 28,74 ± 6,36, trong đó lứa tuổi từ 20 - 29 tuổi chiếm tỷ lệ cao nhất (55%). Kết quả nghiên cứu cho thấy có sự khác biệt giữa thể tích tinh dịch, mật độ tinh trùng, tỷ lệ tinh trùng bình thường tuy nhiên không có sự khác biệt về tỷ lệ tinh trùng di động tiến tới, tốc độ di động tinh trùng giữa các nhóm có tình trạng quan hệ tình dục khác nhau (A - chưa quan hệ tình dục, B - hiện không quan hệ tình dục, C - hiện có quan hệ tình dục). Tần suất xuất tinh có liên quan nghịch biến với thể tích tinh dịch (β = -0,063; p < 0,01), mật độ tinh trùng (β = -3,308; p < 0,01) và có liên quan đồng biến với tỷ lệ tinh trùng bình thường (β = 0,156; p < 0,01). Chúng tôi nhận thấy rằng tần suất xuất tinh có ảnh hưởng đến các chỉ số tinh dịch. Vì vậy, việc tư vấn và giáo dục điều chỉnh tần suất xuất tinh phù hợp có thể là một phương án giúp cải thiện các chỉ số tinh dịch của nam giới.
Giảm tiểu cầu miễn dịch ở trẻ sơ sinh: Tổng quan tài liệu và báo cáo 2 ca bệnh
Authors: Thuỷ Đặng Thị Thu , Thương Nguyễn Hoài , Phương Vũ Thu , Nga Nguyễn Thị Quỳnh
Published: September 2023

Giảm tiểu cầu ở trẻ sơ sinh (neonatal thrombocytopenia - NTP) là một bệnh lý phổ biến do nhiều nguyên nhân gây ra, đa số thường nhẹ và tự giới hạn, thường gặp ở trẻ sơ sinh bị bệnh nặng, trẻ sinh non hoặc chậm tăng trưởng trong tử cung. Tuy nhiên, nhiều trường hợp giảm tiểu cầu xảy ra ở trẻ sơ sinh do cơ chế miễn dịch, dưới tác động của các kháng thể kháng tiểu cầu đồng loại hoặc tự kháng thể tiểu cầu của mẹ truyền qua rau thai. Chúng tôi báo cáo hai trường hợp trẻ sơ sinh được phát hiện giảm tiểu cầu và đều có xét nghiệm kháng thể kháng tiểu cầu dương tính. Trẻ đã được loại trừ các căn nguyên gây giảm tiểu cầu và đủ tiêu chuẩn chẩn đoán giảm tiểu cầu miễn dịch. Kết luận: Ở trẻ sơ sinh bị giảm tiểu cầu cần thăm dò nguyên nhân miễn dịch bên cạnh việc khảo sát các nguyên nhân khác gây giảm tiểu cầu nhằm chẩn đoán xác định, lựa chọn hướng điều trị tối ưu.
Sốt xuất huyết dengue ở trẻ sơ sinh (neonatal dengue) có viêm màng não: Báo cáo ca bệnh
Authors: Quế Phạm Thị , Lâm Nguyễn Văn , Hải Đỗ Thiện
Published: September 2023

Sốt xuất huyết Dengue ở trẻ sơ sinh (Neonatal Dengue) là tình trạng bệnh lý ít gặp, đặc điểm lâm sàng không điển hình, dễ chẩn đoán nhầm với bệnh lý khác. Trẻ sơ sinh nhiễm virus Dengue có thể không có triệu chứng tới biến chứng nặng gây tử vong. Chúng tôi báo cáo trường hợp trẻ nữ 7 ngày tuổi có mẹ mắc sốt xuất huyết Dengue trước đẻ 1 ngày, biểu hiện lâm sàng gồm sốt, phát ban đỏ trên da, gan to, tiểu cầu giảm và Dengue NS1 dương tính từ ngày thứ 2 của bệnh. Trẻ có biến chứng viêm màng não với biểu hiện ngủ li bì, bú kém, thóp phồng nhẹ, số lượng bạch cầu tăng trong dịch não tủy, Dengue IgM và Dengue IgG dương tính trong máu và dịch não tủy, MRI sọ não bình thường. Sau quá trình điều trị bệnh nhân ổn định. Kết luận: Trẻ sơ sinh có mẹ mắc sốt xuất huyết Dengue cần được theo dõi để tránh bị bỏ sót chẩn đoán, biểu hiện lâm sàng gồm sốt, gan to, phát ban và giảm tiểu cầu, có thể gặp biến chứng  viêm màng não.
Từ khóa: Sốt xuất huyết ở trẻ sơ sinh, Viêm màng não liên quan tới virus Dengue, Lây truyền dọc
Opinions of Foreign Convicts Learning Turkish in Penal Institutions on Learning Turkish
Authors: ATİLA Bahadır Ahmet , YORGANCI Osman Kürşat , HARMANKAYA Mustafa Özgün
Published: September 2023

The aim of this study was to explore the perspectives of convicts who are studying Turkish as a foreign language in penal facilities about learning Turkish. Of qualitative research designs a basic qualitative research design was employed in the study, and the data were gathered through semi-structured interviews. The study was carried out with a cohort of 10 foreign convicts in a penal facility located in Ankara. The obtained data underwent content analysis and were subsequently presented in the form of tables. The findings of the research revealed that foreign convicts and detainees aim to learn Turkish for reasons of force majeure, integration, social factors, and future-oriented expectations. Force majeure factors encompassed essential humanitarian needs (such as official and private communication, daily necessities, emotional sharing, healing, health, social and spiritual support, and economic needs) as well as legal needs. Integration-related reasons included considerations of the attitudes of Turkish citizens, the need for belonging, and the need to adapt to prison life. Reasons stemming from social and personal factors included the need to know new people, acculturation, and education. Future-oriented expectations comprised the desire to reside in Türkiye, the desire for an early release, and familial responsibilities. Additionally, the study revealed that convicts learning Turkish as a foreign language encountered challenges linked to the linguistic characteristics of Turkish, personal problems, and constraints during the language learning process.
Cross-National Analysis in the EU: North-South Cleavages as a Conceptual Map of the European Union
Authors: Kučerová Irah
Published: September 2023

Despite seventy years of continued integration, membership of the European Union is still highly differentiated. The asymmetry of economic development concerns several areas. The aim of this analysis was to identify frequent disproportions in performance, as well as differences in the perception of these countries. The method was a comparison of selected EU member states according to Rokkan’s approach of binary entities and Wallerstein's center- periphery model. However, objectively verifiable facts within the conceptual mapping of reality tend to be distorted by the creation of a mental map, when we automatically consider the original EU-15 to be more advanced than EU-13. The analysis carried out does not confirm this assumption.
A glance at the Middle East: Notes on the genus Megastomia from the Arabian Peninsula, with the description of three new species (Gastropoda: Pyramidellidae)
Authors: Nofroni Italo , Renda Walter , Vannozzi Angelo
Published: September 2023

Research on the genus Megastomia Monterosato, 1884 from the Mediterranean Sea led us to study in recent times the species occurring in neighbouring regions, with particular attention to the Red Sea and western Indian Ocean. Among the number of species we examined, we focussed on four of them, characterised by the presence of a fine suprasutural groove, which are presented and illustrated in detail. One of them, originally described as Odostomia, is moved to Megastomia due to the presence of spiral ridges inside the aperture, i.e., M. dorica (Melvill, 1904) n. comb., whereas the other three are described as Megastomia blattereri n. sp. from the northern Red Sea, and M. gorii n. sp. and M. omanensis n. sp. from Oman. Furthermore, the type material of similar species from the Indo-West Pacific, such as Odostomia ovoidea A. Adams, 1860, O. tenera A. Adams, 1860, O. antelia Melvill, 1896, O. eutropia Melvill, 1899, O. metcalfei Pritchard & Gatliff, 1900, O. major Melvill & Standen, 1901, O. dorica Melvill, 1904, O. zaleuca Melvill, 1910, Syrnola lorioli Hornung & Mermod, 1924 and O. (M.) nhatrangensis Saurin, 1959 is illustrated. New generic attributions for several of them are proposed. Furthermore, the lectotype of Odostomia major is designated.
ANALYSIS OF FACTORS AFFECTING UNEMPLOYMENT RATE IN NORTH SUMATRA PROVINCE
Authors: Stellamaris Metekohy  , Silvia Ekasari  , Anton Yuliansyah  , Aminah Lubis  , Nur Jannah Nasution
Published: September 2023

This study aims to determine and analyze factors affecting unemployment rate in North Sumatra Province. This type of research uses quantitative research. Secondary data is sourced from the official publication of the Central Bureau of Statistics for North Sumatra Province. The observation period of this study is from 2000 to 2022. Hypothesis testing using partial test. The results show that investment has a positive and significant effect on unemployment rate in North Sumatra Province. Inflation has a positive and significant effect on unemployment rate in North Sumatra Province.
OSTEOARTHRIRIS PADA LANSIA DI POSYANDU LANSIA DUSUN CEPIRING
Authors: Musdalifa Musdalifa , Nurul Aini Rahmawati  , Dike Dwi Ronawati
Published: September 2023

Lansia biasanya akan mengalami penurunan fungsi tubuh hal ini akan menyebabkan beberapa gangguan pada lansia salah satunya adalah gangguan osteoarthritis. Osteoartritis merupakan penyakit tersering yang menyebabkan timbulnya nyeri dan disabilitas gerakan pada populasi usia lanjut. Penyakit ini menyebabkan nyeri dan disabilitas padapasien sehingga mengganggu aktifitas sehari-hari. Ballottement test dilakukan untuk mengetahui adanya gangguan ostearthritis yang disebabkan oleh kerusakan pada tulang rawan dan sendi.kondisi ini terjadi ketika tulang rawan yang merupakan bantalan pelindung tulang kehilangan elastisitasnya. Akibatnya, terjadi gesekan pada antartulang yang membuatnya lebih rentan mengalami kerusakan dan menyebabkan radang sendi. Ballottement test dilakukan pada lansia yang memiliki usia rata-rata 60 tahun keatas dengan jumlah 25 lansia atau lebih dari 50% lansia mengalami gangguan osteoatrhritis. Untuk penanganan osteoarthritis menggunakan terapi latihan exsercise dan strengthening exercise untuk mengurangi rasa nyeri pada gangguan osteoarthritis.
ANALISIS EFEKTIVITAS DAN PENYAJIAN PSAP NO. 2 PADA DINAS SOSIAL KOTA MALANG TAHUN 2020–2022
Authors: Boja Aria Wastra , Ana Sopanah S  , Endah Puspitosarie
Published: September 2023

This study aims to determine the conformity of the social services budget realization report in Malang City, whether it is in accordance with PSAP No. 2 as well as knowing the effectiveness of social service budget realization in Malang city. The research method used in this research is descriptive qualitative research, which is a research method that utilizes qualitative data and is described descriptively. Malang City Social Service as the object of this research. Primary data was obtained from documents contained in the Malang City Social Service. In addition, interviews were conducted with those concerned and direct observation. The results of this study indicate that Malang City is good and in accordance with the Elements of the Budget Realization Report in PSAP No. 2, starting with providing information on the realization of LRA-income in one period along with its income items, providing information on the realized expenditure budget, providing information on the realized transfer budget, providing information on the realized surplus/deficit budget, providing information on the realized surplus/deficit budget.
ANALISA KUALITAS BAHAN BAKAR JENIS PERTALITE DI SPBU DENGAN PERTALITE DI PERTAMINI BERDASARKAN PARAMETER UJI SPECIFIC GRAVITY, REID VAPOUR PRESSURE, DOCTORT TEST, DISTILASI, COPPER STRIP TEST, OCTANE NUMBER
Authors: Rahma Nuryanti  , Dian Kurnia Sari  , Inta Marlen Puspita Sari
Published: September 2023

Pertalite is a type of fuel with 90-octane level which is used for four- wheeled and two-wheeled vehicles. This study compares the quality of Pertalite fuel at Gas Stations (SPBU) with Pertamina Mini (Pertamini). The aim of the research is to compare the quality of pertaline sold in different places. The parameters used in this research were specific gravity ASTM D-1298 which showed specific gravity 60/60 "F of 0.718 for Gas Station A, 0.719 for Gas Station B, 0.720 for Gas Station C 0.720 at Pertamini A, 0.731 at Pertamini B, and 0.730 at Pertamini C. Then, distillation ASTM D-86 on temperature 90% marked the values of 210 °C, 210°C. 178 °C, and 183 C. Reid vapour pressure ASTM D-323 results were 7.1 Psig. 7.6 Psin. 65 Psig. 7.1 Psig.

3.5 Psig, and 2.9 Psig. Doctor test IP-30 showed the results negative, negative, negative, slightly positive, slightly positive, negative." Copper strip test ASTM D-130 showed the results of 1b, 3b, 2a, 2a, 3h, and 2h. The last test, the octane number ASTM D-2699, showed the results of 90, 89.4, 90, 80, 764, and 87. The results of this study indicated that the values of some parameters for pertalite at gas stations met the spec values, while various test parameters for pertalite ut Pertamini were off spec. It is suggested that the quality of pertalite meet the criteria for the analysis results according to the standard provisions
STUDYING THE LEVEL AND DYNAMICS OF ANTIBODIES PRODUCED IN ORGANISM OF ANIMALS AFTER VACCINATION AGAINST EMCAR
Authors: ӘБУТӘЛІП Ә. , АЙТЖАНОВ Б.Д. , ҚАНАТБАЕВ С.Ғ. , ДӘУҒАЛИЕВА С.Т. , ҚАЙЫПБАЙ Б.Б. , ӘБУБЕКОВА А.Ә. , БАЙМАН А.И. , PELETTO S.
Published: September 2023

Мақалада қарасанға қарсы иммунделген жануарлар ағзасында вакцинациядан кейінгі пайда болатын антиденелер деңгейі және динамикасы туралы мәліметтер келтірілген. Антиденелердің ең жоғары титрі жануардың бір жақ санына қарасан вакцинасының екі есе мөлшері, яғни 4 мл, екінші жағына «Иммунофарм» иммуномодуляторы 5 мл енгізген жануарларда байқалды. Бұл жағдайды, қарасан ауруының алдын алу үшін вакцина қолданғанда, антидене титрінің мейлінше жоғары болып және ұзағырақ сақталынуын қамтамасыз ету үшін пайдалануға болады. Жүргізілген зерттеулер ҚазҒЗВИ-да ойластырылған латекс-аггютинация реакциясы арқылы, қарасанға қарсы иммунделген жануарлардың қан сарысуындағы антиденелер деңгейін және динамикасын анықтауға болатынын көрсетті. Осы тәсілді пайдалана отырып, вакцинацияланған жануарлардағы иммунитет деңгейін және қолданылған вакцинаның сапасын да анықтауға болады.

The article provides data on the level and dynamics of antibodies formed after vaccination in the body of animals immunized against blackleg. The highest antibody titer was observed in animals that were injected with twice as much of the Immunopharm vaccine on one side of the animal, i.e. 4 ml, and on the other-5 ml of the immunomodulator Immunopharm. This condition can be used to ensure that the antibody titer remains as high as possible and lasts longer when using a vaccine to prevent blackleg disease. The conducted studies have shown that using the latex-agglutination reaction developed at Kaznivi, it is possible to determine the levels and dynamics of antibodies in the blood serum of animals immunized againstblackleg. Using this approach, it is also possible to determine the level of immunity and the quality of the vaccine used in vaccinated animals.
Use cases for science blogs: grant-funded projects
Authors: Fenner Martin
Published: September 2023

The Rogue Scholar science blog archive is open to science blogs that want to be enhanced by adding long-term archiving, DOI registration, and full-text search. The currently 56 participating blogs represent a broad spectrum of topics, people, and communities. Today I want to go into more detail into one particular Rogue Scholar use case: science blogs for grant-funded projects.
Descamisados y cabecitas negras: jerarquías-clases sociales, filiaciones políticas y color de piel en la nación peronista, 1943-1955
Authors: Hernández Yepsaly
Published: September 2023

El presente artículo analiza el proceso de construcción de la comunidad imaginada en la “nueva” nación argentina durante el primer peronismo (1943-1955) con énfasis en la utilización de las categorías descamisados y cabecitas negras para distinguir a los “falsos” y “verdaderos” argentinos. El seguimiento de la retórica empleada por los líderes justicialistas, Juan Domingo y Eva Perón pondrá en evidencia el predominio del elemento blanco en la configuración de la nueva Argentina a pesar de su pretendido distanciamiento.
Can specific attributes predict rape proclivity in heterosexual men?
Authors: McCaffrey Liberty
Published: September 2023

Eight attributes were investigated in 144 heterosexual men to establish whether they could significantly predict Rape Proclivity. Whilst 62 per cent of the participants in the sample indicated some proclivity to raping a woman, none of the attributes were significant. These findings were likely due to measurement errors/lack of statistical power, but they could imply that the average rapist is like the public when such predictors are considered.