bluuebunny/crossref_metadata_2025 huggingface dataset:
"Immigration Problems Facing the European Union from the Perspective of UN Human Rights Council Mechanisms"
Authors: Hernandez-Połczyńska Anna
Published: February 2020

The scale of immigration problems in Europe today is well-known and broadly dis-cussed. The article identifies how this issue is reflected in two Human Rights Council mechanisms: Special Procedures and the Universal Periodic Review. The Special Rap-porteur on the human rights of migrants, François Crépeau, undertook a regional study on the management of the external borders of the European Union and its impact on the human rights of migrants. The analysis of the annual and country visits’ reports allows the main immigration problems facing the EU countries and threats for the protection of human rights to be identified. The recommendations made by the Special Rapporteur are confronted with those taken up in the UPR process. Special attention is given to the EU countries’ position on the problem of immigrants. Their reluctance to raise this issue in the UPR weakens the credibility of EU Member States and puts the objectivity of the mechanism into question.
The Views of the Court of Arbitration for Sport and the Austrian Football Association on legal liability for the conduct of supporters
Authors: Vasilyev Ilya , Margarita  Izmalkova Margarita , Khalatova Raisa
Published: February 2020

The clubs legal responsibility for the behavior of supporters is used by UEFA to in-fluence the content of sports competitions, ideally abstracted from demonstrating by spectators any non-football ideas. Nevertheless, the regulation of the national associa-tions-members of UEFA also assumes the responsibility of the clubs and, sometimes, the supporters themselves for the unacceptable behavior of the latter. The experience of regulation this issue by the Austrian Football Association demonstrates mentioned approach. Therefore, it is interesting to make a comparison: how much the regulated responsibility of supporters affects to the regulation by the association a strict liability of clubs for the behavior of fans. Using the practice of CAS, we may see a presumptive approach on the basis of an assessment of the situation by “a reasonable and objective observer” for the objective resolution of a dispute.
Development, optimization and validation of an absolute specific assay for active myeloperoxidase (MPO) and its application in a clinical context: role of MPO specific activity in coronary artery disease
Authors: Trentini Alessandro , Rosta Valentina , Spadaro Savino , Bellini Tiziana , Rizzo Paola , Vieceli Dalla Sega Francesco , Passaro Angelina , Zuliani Giovanni , Gentili Valentina , Campo Gianluca , Cervellati Carlo
Published: February 2020

Background

Myeloperoxidase (MPO) is an enzyme with a recognized prognostic role in coronary artery disease (CAD), which is also emerging as a promising biomarker for cardiac risk stratification. However, the lack of a consensus method for its quantification has hindered its implementation in clinical practice. The aim of our work was to optimize an absolute sensitive assay for active MPO without external standards, to validate the method in the clinical context of CAD patients, and to estimate the enzyme specific activity.

Methods

In order to determine the MPO concentration using fluorescence readings, this ELISA assay exploits the activity of the enzyme recognized by specific antibodies. The assay was validated in a small cohort of patients that included: healthy subjects (n=60); patients with acute myocardial infarction (AMI, n=25); patients with stable CAD (SCAD, n=25) and a concomitant chronic obstructive pulmonary disease (COPD). Then, total MPO concentration and specific activity (activity/total MPO) were determined.

Results

The assay showed an intra- and inter-assay coefficient of variation of 5.8% and 10.4%, respectively, with a limit of detection (LoD) of 0.074 μU. Both AMI and SCAD patients had higher active and total MPO than controls (p<0.0001 and p<0.01, respectively). The specific activity of MPO was higher in SCAD patients compared to both controls and AMI (p<0.0001).

Conclusions

The study presents a robust and sensitive method for assaying MPO activity in biological fluids with low variability. Moreover, the determination of the specific activity could provide novel insight into the role of MPO in cardiovascular diseases (CVDs).
Rethinking Cultural Terminology Translation
Authors: Huang Xinyu , Wei Xiangqing , Liu Runze
Published: February 2020

Jakobson’s article “On linguistic aspects of translation” proposes a tripartite division of translation as intralingual, interlingual, and intersemiotic, which offers a panorama of a semiotic approach to translation, especially to what is translation in a multileveled sense. Subsequent scholars develop the two implicit ideas in his article, named by the author as “translation as sign transformation” and “translation as sign interpretation.” While further widening the scope and enriching the perspective of Jakobson’s typology, current literature remains purely theoretical in essence. As a particular research area, cultural terminology translation could serve as the axis linking theory and practice, which becomes the primary concern for this paper. Grounded on a review of Jakobson’s division and related literature in translation semiotics, this study proposes a multileveled understanding of cultural terminology translation based on some concrete cases. Cultural terminology translation is regarded as “sign transformation” and “sign interpretation.” As sign transformation, it concerns the transformation of conceptual, linguistic, and cultural signs, while as sign interpretation, it goes from intralingual to interlingual to intersemiotic interpretation. This research concludes that cultural terminology translation is a complex sign activity calling for further investigations.
On the classification of Schreier extensions of monoids with non-abelian kernel
Authors: Martins-Ferreira Nelson , Montoli Andrea , Patchkoria Alex , Sobral Manuela
Published: February 2020

We show that any regular (right) Schreier extension of a monoid M by a monoid A induces an abstract kernel

Φ
:

M
→

End
⁡

(
A
)

Inn
⁡

(
A
)

{\Phi\colon M\to\frac{\operatorname{End}(A)}{\operatorname{Inn}(A)}}

.
If an abstract kernel factors through

SEnd
⁡

(
A
)

Inn
⁡

(
A
)

{\frac{\operatorname{SEnd}(A)}{\operatorname{Inn}(A)}}

, where

SEnd
⁡

(
A
)

{\operatorname{SEnd}(A)}

is the monoid of surjective endomorphisms of A, then we associate to it an obstruction, which is an element of the third cohomology group of M with coefficients in the abelian group

U
⁢

(

Z
⁢

(
A
)

)

{U(Z(A))}

of invertible elements of the center

Z
⁢

(
A
)

{Z(A)}

of A, on which M acts via Φ.
An abstract kernel

Φ
:

M
→

SEnd
⁡

(
A
)

Inn
⁡

(
A
)

{\Phi\colon M\to\frac{\operatorname{SEnd}(A)}{\operatorname{Inn}(A)}}

(resp.

Φ
:

M
→

Aut
⁡

(
A
)

Inn
⁡

(
A
)

{\Phi\colon M\to\frac{\operatorname{Aut}(A)}{\operatorname{Inn}(A)}}

) is induced by a regular weakly homogeneous (resp. homogeneous) Schreier extension of M by A if and only if its obstruction is zero.
We also show that the set of isomorphism classes of regular weakly homogeneous (resp. homogeneous) Schreier extensions inducing a given abstract kernel

Φ
:

M
→

SEnd
⁡

(
A
)

Inn
⁡

(
A
)

{\Phi\colon M\to\frac{\operatorname{SEnd}(A)}{\operatorname{Inn}(A)}}

(resp.

Φ
:

M
→

Aut
⁡

(
A
)

Inn
⁡

(
A
)

{\Phi\colon M\to\frac{\operatorname{Aut}(A)}{\operatorname{Inn}(A)}}

), when it is not empty, is in bijection with the second cohomology group of M with coefficients in

U
⁢

(

Z
⁢

(
A
)

)

{U(Z(A))}

.
The development of sex differences in humor initiation and appreciation
Authors: Bergen Doris
Published: February 2020

Both common observations and research evidence strongly suggest that there are major differences between adult males and females as to both the number of humorous attempts they display in social situations and the types of humor they initiate and appreciate. What the causes are for these differences, however, have been less clear, with attributions being related to both biological and environmental reasons. In fact, researchers who have studied the development of humor in infants, preschoolers, and elementary age children have generally observed that the early humor of both boys and girls is similar, thus raising the possibility that the differences that gradually emerge with age may be attributed more to environmental rather than to biological reasons. This chapter will discuss the humor research evidence amassed by those who have studied young children’s humor development and the potential environmental influences on humor development that may account for some of the sex differences seen in adult humor.
The traditional sexual script and humor in courtship
Authors: Ross Elaina M. , Hall Jeffrey A.
Published: February 2020

To account for sex differences in the production, receptivity, and preference for humor in potential mates during courtship, past research has often adopted an evolutionary approach. The present manuscript will attempt to integrate evolutionary explanations with proximal social and cultural influences using the traditional sexual script and ambivalent sexism theory. The results of both Study 1 (N=227) and Study 2 (N=424) suggest that trait masculinity is positively associated with humor production in courtship, while trait femininity is associated with humor receptivity. Study 1 indicated that the traditional flirting style was associated with less humor production by women, and Study 2 indicated that hostile sexism was related to a lower preference for a humor-producing potential partner by men. A sex difference in humor production in potential partners in Study 2 was no longer detectable once trait gender and hostile sexism was accounted for. Taken together, gender roles, over and above biological sex, influence one’s own humor use in courtship and preference for humor in potential partners.
Protection Coordination of Radial Distribution Networks Connected with Distributed Generation Considering Auto-reclosing Schemes by Resistive Superconducting Fault Current Limiters
Authors: Hammad Hammad Mahrous , Aly Mohamed M.
Published: February 2020

Radial distribution networks are normally protected against fault currents by fuses and reclosers. This protection is coordinated in a way that reclosers clear temporary faults before the melting of fuses and fuses melt to clear permanent faults. Distribution networks, which are recently connected with distributed generations (DGs), incur a variety of issues that are certainly worthy of closer considerations. One of these issues is the operation of protection devices. Recloser-fuse coordination may be lost when DGs are integrated with distribution networks due to the effect of current flowing from DGs during fault period and the breaking of the radiality nature of these networks. The impact of DGs on recloser-fuse coordination depends on penetration level, location, and type of DG. Recloser-fuse coordination of radial distribution networks connected with DGs can be kept by connecting resistive superconducting fault current limiter (R-SFCL) in series with the DG to limit the fault current contribution of DG during the fault period. However, when considering the auto-reclosing scheme of the recloser, recloser-fuse coordination may be lost even if R-SFCL is connected. This paper shows the effectiveness of R-SFCL to restore recloser-fuse coordination without considering auto-reclosing scheme. It also proposes solution methods based on three different configurations of R-SFCL to maintain recloser-fuse coordination when auto-reclosing scheme is considered. Simulation results illustrate the effectiveness of the proposed configurations of R-SFCL to keep recloser-fuse coordination. All simulations are performed using MATLAB/Simulink package.
Individualistic and Structural Explanations in Ásta’sCategories We Live By
Authors: Griffith Aaron M.
Published: February 2020

Ásta’sCategories We Live Byis a superb addition to the literature on social metaphysics. In it she offers a powerful framework for understanding the creation and maintenance of social categories. In this commentary piece, I want to draw attention to Ásta’s reliance on explanatory individualism – the view that the social world is best explained by the actions and attitudes of individuals. I argue that this reliance makes it difficult for Ásta to explain how many social categories are maintained and why certain categories are reliably available to us and so resistant to change. These explanatory deficiencies could be overcome, I argue, by eschewing explanatory individualism and positing social structures to figure in structural explanations of the maintenance and availability of social categories.
Crystal structure of (N-benzyl-N-methyl-dithiocarbamato-κ2
S,S′)di(4-chlorobenzyl)chloridotin(IV), C23H22Cl3NS2Sn
Authors: Lo Kong Mun , Mun Lee See , Tiekink Edward R.T.
Published: February 2020

C23H22Cl3NS2Sn, triclinic, P1̄ (no. 2), a = 9.3954(1) Å, b = 10.2747(1) Å, c = 12.8743(2) Å, α = 99.427(1)°, β = 94.247(1)°, γ = 95.817(1)°, V = 1214.51(3) Å3, Z = 2, R
gt(F) = 0.0167, wR
ref(F
2) = 0.0446, T = 100(2) K.
Study of differential transform technique for transient hydromagnetic Jeffrey fluid flow from a stretching sheet
Authors: Kumar Mahesh
Published: February 2020

This article investigates the time-dependent MHD heat transfer flow of Jeffrey fluid from a stretching sheet, the topic significance to non-Newtonian viscoelastic material processing. Using similarity transformations, the governing coupled non-linear PDE’s are remodel into ODE’s with suitable free stream and wall boundary conditions. The developed non-dimensional non-linear problem is revealed to be analysed by several key thermosphysical and rheological parameters, namely, Jeffrey fluid parameter (λ), Deborah number (β), Prandtl number (Pr), buoyancy parameter (ξ), magnetic parameter (M) and unsteadiness parameter (A). The semi-exact differential transform technique is applied to elucidate the coupled nonlinear governing equation of non-Newtonian Jeffrey fluid problem. Also, the solution is validated with numerical results attained via the MATLAB bvp4c function. Excellent accurateness is attained through the DTM approach. Further validation with available consequences from the existing literature is incorporated. The results indicate that fluid velocity and temperature are boosted with increasing Deborah number and stretching parameter however it shows a decreasing trend with Jeffrey fluid parameter and convection parameter. It also shows when augmenting the magnetic parameter which reduces the flow and increases the thickness of the boundary layer.
About classical solutions of the path-dependent heat equation
Authors: Di Girolami Cristina , Russo Francesco
Published: February 2020

This paper investigates two existence theorems for the path-dependent heat equation, which is the Kolmogorov equation related to the window Brownian motion, considered as a

C
⁢

(

[

-
T

,
0
]

)

{C([-T,0])}

-valued process.
We concentrate on two general existence results of its classical solutions related to different classes of terminal conditions: the first one is given by a cylindrical not necessarily smooth random variable, the second one is a smooth generic functional.
One-pot multi-component process for the synthesis of 4-azaphenanthrene-3,10-dione, 1,8-dioxo-octahydroxanthene and tetrahydrobenzo[b]pyran derivatives catalyzed by the deep eutectic solvent choline chloride-oxalic acid
Authors: Sayahi Mohammad Hosein , Gorjizadeh Maryam , Meheiseni Melan , Sayyahi Soheil
Published: February 2020

An effective method based on choline chloride (ChCl)-oxalic acid (Ox) deep eutectic solvent was proposed for the synthesis of 4-azaphenanthrene-3,10-dione, 1,8-dioxo-octahydroxanthene and tetrahydrobenzo[b]pyran derivatives. The eutectic mixture worked as both the solvent and acidic catalyst for conversion. The impacts of different variables, including the composition and volume of ChCl-Ox, and temperature, on reaction yield were studied for optimization. The crucial advantages of this process are simplicity of the experimental procedure, high yields, short reaction times, high recyclability, and the use of safe and inexpensive components.
Mechanical, Structural and Optical Properties of the Silicon Nanowire Arrays
Authors: Muthuvel Ramuvel , Arunachalam Manimaran , Karanthamalai Vinayagar , Venkatesan Ragavendran , Venkatachalapathy Vishnukanthan , Mayandi Jeyanthinath
Published: February 2020

The present work discusses the systematic study of mechanical properties of the silicon nanostructures formed by metal assisted chemical etching (MACE). Silver electrolyte solution, along with hydrogen fluoride, was utilized in formation of silicon nanostructures. An optimized condition of etching time and silver electrolyte concentration were utilized to obtain high aspect ratio, defect-free and high density nanowire arrays on Si wafers. The as-prepared silicon nanostructures (SiNS) were investigated by Scanning electron microscopy (SEM) and nano indentation technique to bring out the morphological and mechanical properties. Further, the variation in optical properties of the bulk silicon and Si nanowire arrays were also investigated to determine the formation of nanostructures.
Рийна діяльність прудкої ящірки в умовах Присамар’я
Authors: Gasso V. Y.
Published: February 2020

Представлено результати досліджень обсягів рийної діяльності прудкої ящіркиу степовому та лісовому (суховатий бір) біогеоценозах Присамар’я. Визначено гли-бину занурення та довжину ходу нір, об’єм та масу винесеного на поверхню ґрунтуяк з однієї нори, так й у перерахунку на гектар. Встановлено, що нори прудкої ящір-ки можуть відрізнятися за будовою у двох типах біогеоценозів. Об’єм та маса ґрун-ту, який виноситься з однієї нори на поверхню, більші у бору на 20 % та 280 % відпо-відно. Однак у перерахунку на гектар лише маса винесеного ґрунту достовірно біль-ша в лісовій екосистемі.
Obituary
Authors: Gröning Linda , Jacobsen Jørn
Published: February 2020

On the 22nd of July 2019, professor Per Ole Träskman passed away at age 75. Bornin 1944, Per Ole Träskman’s enitre working life was dedicated to criminal law. TheNordic criminal law environment has lost one of its most essential contributors anddistinct and admirable personalities.
THE ROLE OF JOB CRAFTING ON THE PROMOTION OF FLOW AND WELLBEING
Authors: DEVOTTO RITA P. de , FREITAS CLARISSA P. P. , WECHSLER SOLANGE M.
Published: February 2020

ABSTRACT Purpose: To investigate the mediating role of flow at work on the relations of job crafting (task crafting, cognitive crafting and relational crafting) with positive mental health dimensions (emotional well-being, psychological well-being and social well-being). Originality/value: Job crafting actions have been identified as antecedents of the levels of well-being at work. The present study contributed to the literature examining the relationships between job crafting, flow at work, and positive mental health, which have not yet been investigated in previous empirical studies. Design/methodology/approach: The quantitative approach was used through an online questionnaire composed of a sociodemographic questionnaire and three scales. The sample consisted of 386 professionals from different Brazilian states, of which 58% were female, with a mean age of 44 years (SD = 12 years). The data were analyzed through structural equations. Findings: The results of the analysis of structural equations showed that relational crafting had a direct impact on positive mental health. The relations of cognitive crafting with positive mental health were totally mediated by flow at work. We concluded that job crafting, primarily cognitive crafting, influence occupational and general well-being.
PRESENTEEISM OF CLASS TEACHERS: WELL-BEING AS A CRITICAL PSYCHOLOGICAL STATE IN THE MEDIATION OF JOB CHARACTERISTICS
Authors: PÉREZ-NEBRA AMALIA R. , QUEIROGA FABIANA , OLIVEIRA THIAGO A.
Published: February 2020

ABSTRACT Purpose: Test job fulfillment as a mediator of the relationship between work design and presenteeism in teachers. Originality/value: Presenteeism is one of the reasons for teachers to underperform in the classroom. Many models explain organizational results, among which the Job Characteristics Model. That model, however, has not yet been tested with presenteeism, and, as it proposes, it will be predicted by work design mediated by positive work-related attitudes (i.e., eudaimonic well-being). Design/methodology/approach: A total of 2,282 public school teachers participated in the study, of which 71.1% were women. They completed the scale of job fulfillment, the Stanford Presenteeism Scale, and the full work design taxonomy in the Brazilian version. Direct and mediated relationships were tested, and the Job Characteristics Model was partially confirmed. Findings: For not completing work, mediation is confirmed only to the task identity subcategory of work design. Here, direct relationships with scheduling autonomy and social support were observed. For avoiding distraction, mediation occurred only for social support, and comfort at work. The subcategories decision-making autonomy, physical demands, and job complexity are directly related. We discuss the mediating role of critical psychological states and other positive triggers that could mediate the relationship between work design and organizational outcomes, such as emotions.
Flora do Ceará, Brasil: Phyllanthaceae
Authors: Lima Igor Gonçalves , Rebouças Natanael Costa , Ribeiro Rayane de Tasso Moreira , Loiola Maria Iracema Bezerra
Published: February 2020

Resumo Apresentamos o levantamento florístico de Phyllanthaceae no estado do Ceará, como parte do projeto Flora do Ceará: conhecer para conservar. O estudo baseou-se na análise de coleções depositadas em herbários e observação de populações naturais no campo. Phyllanthaceae está representada por 14 espécies e quatro gêneros: Hieronyma (2), Margaritaria (1), Phyllanthus (10) e Savia (1). A ocorrência das espécies Hieronyma alchorneoides, H. oblonga e Margaritaria nobilis, assim como Phyllanthus acuminatus, P. carmenluciae, P. caroliniensis, P. heteradenius e P. stipulatus constituem novos registros para o estado. As espécies ocorrem preferencialmente em floresta ombrófila densa (mata úmida) e savana estépica (caatinga), havendo registros em Unidades de Conservação do Ceará.
Bambusoideae (Poaceae) no Parque Estadual da Serra do Brigadeiro, Minas Gerais, Brasil
Authors: Silva Alaísma Pereira da , Machado Evandro Pianissola , Clark Lynn G. , Santos-Gonçalves Ana Paula
Published: February 2020

Resumo O presente estudo trata do levantamento florístico das espécies de Bambusoideae (Poaceae) que ocorrem no Parque Estadual da Serra do Brigadeiro (PESB), Minas Gerais, Brasil. O domínio fitogeográfico em que a área de estudo está inserida é a Floresta Atlântica, considerada um dos centros de endemismo de bambus. Foram realizadas expedições de agosto de 2013 a julho de 2015 para a coleta do material botânico e observação das espécies no seu ambiente natural. Além disso, foram analisadas as coleções dos herbários BHCB, CESJ, HUEFS, ISC, K, MG, RB, SPF, VIC e VIES. Foram registradas 27 espécies pertencentes a seis gêneros. O gênero com maior número de espécies é Chusquea, com 16 espécies, seguido de Merostachys e Aulonemia, com quatro espécies cada, e Colanthelia, Guadua e Parodiolyra com uma espécie cada. São apresentadas chaves de identificação para os gêneros e as espécies, descrições e comentários morfológicos. O PESB apresenta a maior riqueza de espécies de bambus já registrada nas unidades de conservação de Minas Gerais.
Flora da Reserva Ducke, Amazonas, Brasil: Stemonuraceae
Authors: Amorim Bruno Sampaio , Cardozo Nállarett Dávilla , Albuquerque Patricia Melchionna , Cabral Fernanda Nunes
Published: February 2020

Resumo O presente trabalho tem como objetivo contribuir para o conhecimento da família Stemonuraceae ocorrente na Reserva Ducke. O estudo tem por base a análise morfológica de materiais depositados em herbários e revisão de literatura. Apenas uma espécie foi registrada: Discophora guianensis. O presente estudo contém descrições morfológicas, ilustrações, dados sobre habitat, fenologia, dados de distribuição geográfica e comentários taxonômicos para a espécie tratada.
Efectos de la dependencia al celular en las habilidades sociales de los estudiantes universitarios
Authors: De la Cruz Sandoval Diana , Torres Zárate Luz , Yánac Cierto Elí
Published: February 2020

Objetivo: Determinar la relación entre dependencia al celular y habilidades sociales de los estudiantes de una universidad privada de Lima Este. Metodología: Se utilizó el diseño no experimental de corte transversal y de tipo correlacional. Asimismo, se empleó un muestreo no probabilístico intencional, incluyendo alumnos de ambos sexos con edades entre 17 a 28 años. Resultados: El 52.1% de los universitarios se encuentran en riesgo de presentar dependencia al celular, mientras el 22.8% ya lo presenta frente a un 25.1% que no. Asimismo, el 56.1% de los estudiantes evidencian bajo nivel de habilidades sociales, el 29.9% están en proceso de desarrollarlos y solo el 14% han desarrollado las habilidades sociales. Además, se encontró relación negativa y altamente significativa entre las variables de estudio (Rho=-,645**; p<0.01), de igual manera se encontró relación negativa y altamente significativa en las dimensiones de dependencia al celular con el total de habilidades sociales: “abstinencia” (Rho=-,624**;p<0.01), “abuso y dificultad de controlar el impulso” (Rho=-,526**;p<0.01), “problemas ocasionados por el uso excesivo” (Rho=-,595**; p<0.01) y “tolerancia” (Rho=-,569**; p<0.01) Conclusión: La dependencia al celular si se relaciona altamente significativa y de manera inversa con las habilidades sociales. Es decir, a mayor dependencia del celular se asocia un nivel menor de habilidades sociales y viceversa.
Wildfires as a Public Health Problem: a Setting for Nursing in Disasters
Authors: Barría P R Mauricio
Published: February 2020

Climate change and global warming are phenomena that are progressively affecting the planet. Temperature changes have been posing mayor threats for different domains of human society. One of these threats is related to health due extreme temperatures, and natural disasters. Thus, it is constituted as a global threat to biodiversity and the human population, since not only affects ecosystems equilibrium but increasing wildfires as consequence of increased temperaturesand diminished precipitations. Moreover,wildfires have concentrated attention not only because of their ecological and environmental consequences but also for affecting production, economics, and health of people potentially exposed to environmental risks such fire, smoke, and others chemical products released from wood combustion process. How to cite this article: Barría RM. Wildfires as a Public Health Problem: a Setting for Nursing in Disasters. Invest. Educ. Enferm. 2019;37(3):e01.
18F-fluorodeoxyglucose positron emission tomography combined with computed tomography for the prediction of radioiodine therapy response in patients with metastatic differentiated thyroid cancer
Authors: Geliashvili T. M. , Vazhenin A. V. , Berezovskaya T. P. , Afanasyeva N. G. , Vasilyeva E. V. , Garbuzov P. I. , Krylov V. V.
Published: February 2020

The study objective was to investigate the role of 18 F-fluorodeoxyglucose (18 F-FDG) positron emission tomography combined with computed tomography (PET-CT) as an indirect determination of the differentiation status of metastases and for the prediction of radioactive iodine (RAI) therapy response in patients with metastatic differentiated thyroid cancer.Materials and methods. The 40 metastatic differentiated thyroid cancer patients were enrolled in the study that underwent both post-therapeutic radioiodine scan and PET-CT at the same period.Results. The study found that 12 (30 %) patients responded to RAI therapy. The remaining 28 (70 %) patients not responded to RAI therapy showed stabilization or progression. The accumulation of radioiodine by metastases positively correlated with the total response rate, while the 18 F-FDG avidity is negative. Significant direct correlation with response rate was observed in the group with only radioiodine uptake. However, this correlation was not observed in the patients with both tracers uptake. The patients with 18 F-FDG-positive metastases showed poor response to RAI therapy, regardless of the degree of radioiodine uptake.Conclusion. The 18 F-FDG uptake by metastases is a predictor of a poor response to RAI therapy, even in the presence of RAI uptake. The use of 18 F-FDG PET-CT in patients with metastatic differentiated thyroid cancer can be recommended at the beginning of RAI therapy to clarify the prognosis and provide a personalized approach to the treatment and observation of the most difficult category of patients.
Use of the Hedgehog signaling pathway inhibitor in the treatment of recurrent locally advanced and metastatic basal cell skin cancer
Authors: Radzhabova Z. A.-G. , Kotov M. A. , Bekyasheva Z. S. , Radzhabova M. A. , Levchenko E. V.
Published: February 2020

The study objectiveis to provide data on the use of the Hedgehog signaling pathway inhibitor (vismodegib) in the treatment of recurrent locally advanced and metastatic basal cell skin cancer at the N. N. Petrov National Medical Research Center of Oncology.

Materials and methods. Clinical data of 10 patients who participated in a multicenter, non-randomized clinical trial of phase II ERIVANCE BBC (ClinicalTrials. gov NCT833417). Patients took the daily studied drug vismodegib orally at a dose of 150 mg daily until disease progression or intolerance due to side effects. Efficiency and safety assessment was carried out once every 4 weeks.

Results. Complete regression was achieved in 7 patients, while the average duration of use of the drug was 240 ± 65 days. Stabilization was observed in 2 patients, the minimum duration of the drug was 336 days. One patient showed progression after 728 days of taking the drug. Side effects of the 1 grade according to CTCAE (Common Terminology Criteria for Adverse Events), v. 3.0 were observed in all patients, in 9 they were expressed in muscle cramps, alopecia and changes in taste sensitivity, and in 1 patient isolated in the form of muscle cramps.

Conclusion. The results show a good safety profile of vismodegib, which allows it to be used in elderly patients with concomitant pathology. The frequency of response to treatment, including the achievement of complete regression in 70 % of patients, makes vismodegib an acceptable treatment option for metastatic form of basal cell skin cancer and relapse of locally advanced forms.
The meaning of soft skills in the modern professional career
Authors: Malova Maria M.
Published: February 2020

This article identifies the importance of students’ soft skills building for education and their future career. Modern professional activity does not require only specific knowledge, but also soft skills necessary for specific professional field. Presently, soft skills play vital roles in the workplace for they raise professional levels and promote successful careers. Therefore, the purpose of higher education is to produce specialists able to work in competitive environments, which require introducing technologies that form students’ soft skills. In the article, we have justified the choice of the most valuable students’ personal and professional qualities required for forming soft skills in the learning process. The importance of self-organization and ability to work on a team has been revealed on the basis of analyzing psychological and pedagogical literature. The relevance of self-organization and working collaboratively has been supported by data obtained from the soft skills ratings provided by Russian and western employers. We found that soft skills based on the quality of self-organization and working on a team are in the Top-10 of analyzed ratings demonstrating their importance in Russia’s modern labor market. Consequently, the assessment technology aimed at forming students’ personal and professional skills will be developed and tested during final stages of our research.
EXPERIMENTAL INTESTINAL DYSBIOSIS IN RATS INCREASES THE PERMEABILITY OF THE BLOOD-BRAIN BARRIER AND INDUCES NEUROINFLAMMATION
Authors: Sergeyev V G , Sergeyeva T N
Published: February 2020

The mammalian intestinal microbiota consists of bacteria, fungi and viruses, including bacteriophages. This complex ecosystem has dynamic stability. It is assumed that changes in the composition of the microbiota can cause intestinal barrier dysfunction and the development of a number of pathologies, including neurodegenerative diseases accompanied by neuroinflammation. The molecular and cellular mechanisms underlying such a relationship remain poorly understood. We hypothesized that bacteriophages cause intestinal dysbiosis, increased intestinal permeability and local inflammation. Bacterial factors (endotoxins, zonulin-like proteins) and local inflammation products (cytokines, alpha-synuclein protein) can enter the circulation and increase the permeability of the blood-brain barrier (BBB), which will cause neuro-inflammation and damage to neurons. In this study, we observed an increase in BBB permeability and induction of neuroinflammation in the brain after rectal administration of a bacteriophage cocktail (Microgen, Russia). The permeability of the BBB was judged by the volume of the vital dye (Evans blue) emerging from the bloodstream into the brain parenchyma, and the development of the neuroinflammatory response by increasing the number of immunohistochemically stained microglial and astroglial cells.
THE EFFECT OF CHEMOKINE CXCL-13 ON THE CLINICAL AND FUNCTIONAL STATUS OF PATIENTS WITH MULTIPLE SCLEROSIS IN REMISSION
Authors: Sursiakova N V , Kuklina E M , Baidina T V , Nekrasova I V
Published: February 2020

Introduction. CXCL-13 can be involved in the development of MS, and its level in peripheral blood may have diagnostic and / or prognostic significance. The purpose of this study is to assess the level of CXCL-13 in serum and its relationship with the clinical and functional state of patients with remitting MS in remission. Materials and methods. The study involved 67 patients (28 men and 39 women) with a relapsing MS in remission. All patients were examined by scales and questionaries EDSS, Multiple Sclerosis Functional Composite, Multiple Sclerosis Impact Scale 29, Fatigue Severity Scale. On the day of the clinical examination venous blood samples were taken from patients and healthy donors, serum was isolated, and the level of CXCL-13 was assessed by enzyme immunoassay method. Results and discussion. It was revealed that CXCL-13 in the serum in patients with MS was significantly lower than in healthy volunteers. A relationship was found between serum CXCL-13 and the severity of neurological deficit according to EDSS, with walking speed of 25 feet, with an assessment of the quality of life and fatigue. Conclusions. Despite the association of CXCL-13 with the clinical and functional state of MS patients, at present time this chemokine cannot be considered to be a diagnostic or prognostic marker in MS patients.
THE EFFECT OF PRO-INFLAMMATORY CYTOKINE IL-1β ON THE CENTRAL AND PERIPHERAL RESPIRATORY CONTROL MECHANISMS ON THE BACKGROUND OF SEVERE HYPOXIA
Authors: Baranova E V
Published: February 2020

Pro-inflammatory cytokine IL-1β, as inflammatory mediators participate in neuroimmune interactions in the central nervous system. It’s assumed that IL-1β affect the central and peripheral breathing control in acute hypoxia that occurs simultaneously with systemic inflammation. The purpose of this study was to evaluate the influence IL-1β on respiratory responses following progressive hypoxia and ability to survive after hypoxic apnea. We studied the influence of IL-1β (10 μg/kg) on respiration and the ability to survive acute hypoxic challenge in anesthetized Wistar rats. The response of tidal volume, breathing rate, minute lung ventilation, oxygen saturation, during acute hypoxia was examined using pneumotachography methods. Increasing hypoxia was created by rebreathing method. The results indicated that during progressive acute hypoxia animals given IL-1β were unable to sustain breathing efforts for as long as control rats. Following hypoxic apnea IL-1β decrease the ability to autoresuscitate compared with control groups. Thus IL-1β reduces the tolerance of animals to acute hypoxia and the ability to spontaneously autoresuscitate after apnea. We assume that that IL-1β inhibit inspiratory neurons and decrease the sensitivity of the carotid chemoreceptors to hypoxic stimulation.
INFLUENCE OF SEMAX ON THE LEVEL OF INTERLEUKIN-1βIN THE CONDITIONS OF “SOCIAL” STRESS
Authors: Yasenyavskaya A L , Samotrueva M A , Myasoedov N F , Andreeva L A
Published: February 2020

A study on the effect of Semax on the level of interleukin-1β under conditions of “social” stress was performed on non-white white rats-males. The formation of a stress reaction under the conditions of “social” exposure was confirmed by the presence of a “stress triad”, including adrenal hypertrophy, a decrease in the number of eosinophils in the peripheral blood and the presence of erosive and ulcerative lesions of the gastric mucosa. The level of serum IL-1β was determined by the method of enzyme-linked immunosorbent assay (ELISA). “Social” stress, formed as a result of inter-male confrontations, is accompanied by an increase in cytokine production, manifested by an increase in the concentration of interleukin-1β. Against the background of Semax administration to stressed animals, we can speak of this representative from the group of neuropeptides, as a possible means of correction, contributing to a decrease in the level of IL-1β.
CHANGES OF INTESTINAL MICROBIOME IN MULTIPLE SCLEROSIS ARE ASSOCIATED WITH IMMUNE SHIFT AND PSYCHOEMOTIONAL DISORDERS
Authors: Abdurasulova I N , Matsulevich A V , Tarasova E A , Kudryavtsev I V , Nikiforova I G , Serebryakova M K , Miroshnichenko M I , Ivashkova E V , Tatarinov A E , Ilves A G , Ermolenko E I , Bisaga G N , Stolyarov I D , Klimenko V M
Published: February 2020

Recently, the role of the intestinal microbiota in MS has been actively investigated in connection with its influence the development and activity of immune and nervous systems. It is assumed that immune dysfunction, as well as disorders of the gastrointestinal tract and psycho-emotional functions in patients with MS, may be associated with intestinal microbiocenosis dysbiosis. The aim of the study was to assess changes in the intestinal microbiome in MS patients and to analyze the associations of the bacterial level with various subsets of Th cells in the blood and psycho-emotional disorders. 126 MS patients with disease duration of 12.2 ± 0.9 years and 69 healthy individuals were examined. Intestinal microbiome was determined by the Illumina/Solexa sequencing method. The quantitative content of microbial species was determined by the method of cultivation and real time PCR with specific primers, subsets of Th cells - by flow cytometry. Patients were assessed for anxiety, depression, and asthenia. It was shown that the intestinal microbiome of MS patients was significantly changed compared with healthy individuals: the proportion of Bacteroides, especially of the Prevotellaceae family, was reduced, the proportion of Firmicutes (Bacilli and Clostridia) and Actinobacteria was increased, and the symbiotic species in Enterobacteriaceae family were replaced by opportunistic species. A positive correlation between the level of Bifibobacteria spp. with disease severity and blood levels of DP Th17 CM cells. Enterobacter spp. level correlated with the level of “classical” or Th17/22 CM and DP Th17 EM. Bifidobacteria spp. the level was also associated with the level of depression in patients, the level of Escherichia coli and Prevotella spp. - with anxiety, and the level of atypical E. coli and Sutterella spp. - with asthenia. The data obtained suggest that immune and psycho-emotional disorders in patients with MS can be corrected by normalizing intestinal microbiocenosis.
IMMUNOLOGICAL MARKERS OF LONG-TERM EFFECTS OF TREATMENT IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT
Authors: Krynskiy S A , Malashenkova I K , Hailov N A , Ogurtsov D P , Chekulaeva E I , Ponomareva E V , Gavrilova S I , Didkovsky N A
Published: February 2020

The goal of this research was to study the clinical efficacy of course-based neurotrophic therapy in mild cognitive impairment (MCI) and the effect of therapy on immune parameters in patients, and to assess the prognostic value of the dynamics of immune parameters during the year after treatment. 20 patients with MCI receiving intravenous Cerebrolysin (20 infusions of 30 ml with increasing dose during the first four days) were examined. Neuropsychological and immunological examination was carried out immediately before the study, after 3 months., 6 months and after 1 year after the end of treatment. It was found that after therapy, patients had a long-term decrease in the severity of systemic inflammatory response, and that marked signs of systemic inflammation at the beginning of follow-up combined with a persistent decrease in the level of immunoglobulin G in dynamics were prognostic markers of MCI progression. In conclusion, it wass shown that neurotrophic therapy has a good clinical effect and has a favorable immunomodulatory effect in aMCI, and the relationship between the dynamics of humoral immunity and systemic inflammation and the risk of progression of cognitive impairment in patients within 1 year after therapy was established.
HUBUNGAN PENGETAHUAN GIZI ORANGTUA DAN PENDAPATAN ORANGTUA DENGAN KEPATUHAN ORANGTUA DALAM PENERAPAN DIET AUTIS PADA ANAK AUTIS DI SLB AUTIS LABORATORIUM UNIVERSITAS NEGERI MALANG
Authors: Handayani Poncowuri , Devi Mazarina , Kurniawan Agung
Published: February 2020

Abstract: Autism is a behavioral deviation syndrome in children that involves sensory systems, communication skills, and socialization skills in community. Parental obedience in applying the diet should be consistent in order to reduce symptoms are undergone by children with autism. This study aims to determine the relationship between parental nutrition knowledge and parental income to parent’s obedience of complience in the application of autism diet in children with autism in the SLB Autis Laboratorium Malang State University. The type of this research is quantitative research with cross sectional study design. Parental knowledge was measured from a knowledge questionnaire, and income was measured by the per-capita income category per month and parental compliance was measured from Food Frequency Questionare (FFQ). The results showed that there was a significant correlation between parent’s nutritional knowledge and parent’s obedience to the application of the autism diet at SLB Autis Laboratorium Malang State University (p = 0,004) and there was a significant correlation between parent’s income with parent’s obedience to the application of the autism diet at SLB Autis Laboratorium Malang State University (p = 0,020). Suggestions for the next research to conduct more detailed research about per capita income of family by considering another factor.Keywords: knowledge, income, obedience, autism dietAbstrak: Autisme adalah suatu sindroma penyimpangan perilaku pada anak yang melibatkan sistem sensoris, kemampuan komunikasi, serta kemampuan sosialisasi dimasyarakat. Kepatuhan orang tua dalam menerapkan diet harus konsisten agar dapat mengurangi gejala yang dialami oleh anak autis. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan gizi dan pendapatan orangtua terhadap kepatuhan orangtua dalam penerapan diet autis pada anak autis di SLB Autis Laboratorium Universitas Negeri Malang. Jenis penelitian ini adalah penelitian kuantitatif dengan rancangan penelitian cross sectional. Pengetahuan orangtua diukur dari kuesioner pengetahuan, dan pendapatan diukur berdasarkan kategori pendapatan perkapita keluarga perbulan dan kepatuhan orangtua diukur dari Food Frequency Questionare (FFQ). Hasil penelitian menunjukkan bahwa terdapat hubungan yang signifikan antara pengetahuan gizi orangtua dengan kepatuhan orangtua dalam penerapan diet autis di SLB Autis Laboratorium Universitas Negeri Malang (p=0,004) serta terdapat hubungan yang signifikan antara pendapatan orangtua dengan kepatuhan orangtua dalam penerapan diet autis di SLB Autis Laboratorium Universitas Negeri Malang (p=0,020).  Saran bagi peneliti selanjutnya agar melakukan penelitian lebih mendetail lagi mengenai pendapatan perkapita keluarga dan dengan melihat faktor lain. Kata kunci: pengetahuan, pendapatan, kepatuhan, diet autis
Comparative study on data mining techniques used to predict risk of Heart Disease
Authors: Mhatre Tejali Chandrakant , Varma Satishkumar
Published: February 2020

Heart disease is considered as one of the major causes of death throughout the world. Classification of heart disease can be valuable for medical practitioners to predict disease at early stage. To get accurate result of prediction of disease medical diagnosis system     very useful. There are different data mining techniques available to classify medical data related to heart disease. In this paper, survey is carried out to find which are different data mining techniques can be used for heart disease prediction system.
Acquired neuromuscular weakness In Intensive Care Unit: Review article
Authors: Hamdy Elghotmy Mohamed , Elewa Hamdy , Rabea Mohamed
Published: February 2020

A substantial number of patients admitted to the ICU because of an acute illness, complicated surgery, severe trauma, or burn injury will develop a de novo form of muscle weakness during the ICU stay that is referred to as “intensive care unit acquired weakness” (ICUAW). This ICUAW evoked by critical illness can be due to axonal neuropathy, primary myopathy, or both. Underlying pathophysiological mechanisms comprise microvascular, electrical, metabolic, and bioenergetic alterations, interacting in a complex way and culminating in loss of muscle strength and/or muscle atrophy. ICUAW is typically symmetrical and affects predominantly proximal limb muscles and respiratory muscles, whereas facial and ocular muscles are often spared. ICUAW is diagnosed in awake and cooperative patients by bedside manual testing of muscle strength and the severity is scored by the Medical Research Council sum score. In cases of atypical clinical presentation or evolution, additional electrophysiological testing may be required for differential diagnosis. The cornerstones of prevention are aggressive treatment of sepsis, early mobilization, preventing hyperglycemia with insulin, and avoiding the use parenteral nutrition during the first week of critical illness. Future research should focus on new preventive and/or therapeutic strategies for this detrimental complication of critical illness and on clarifying how ICUAW contributes to poor longer-term prognosis.
Reserva extrativista (RESEX) marinha Mãe Grande de Curuçá: gestão ambiental e possibilidade de turismo na comunidade da Vila de Mutucal
Authors: Trindade Lione Das Neves , Aguiar Ponciana Freire de
Published: February 2020

Este trabalho teve por objetivo analisar a relação entre gestão ambiental, turismo e paisagem na RESEX Marinha Mãe Grande de Curuçá, considerando a interação entre comunidade local e meio ambiente, destacando a gestão ambiental como importante fator para a proteção dos recursos naturais, bem como um manejo adequado da paisagem natural, que se configura como um atrativo turístico haja vista que essa área apresenta um potencial turístico bastante significativo e grande parte dos moradores mostraram-se interessados em desenvolver esta atividade, pois seria uma alternativa viável, desde que houvesse uma organização, planejamento e qualificação da comunidade.Palavras-chave: RESEX Marinha Mãe Grande de Curuçá. Gestão ambiental. Turismo. Paisagem.