bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH SENAM HIPERTENSI TERHADAP PENURUNAN TEKANAN DARAH PADA PENDERITA HIPERTENSI
Authors: Dewi Rury Arindari  , Hendi Rifqi Alhafis
Published: July 2021

One in ten adults in the world has high blood pressure. World Health Organization (WHO) year (2016) called hypertension as "an epidemic that spreads beyond. Management of hypertension from it all can be prevented through nonpharmacological therapy that is by exercising regularly. According to data obtained from the Alang-Alang Lebar Public Health Center in Palembang it is known that the number of hypertensive sufferers in 2018 is 1,781 people. The purpose of this study was to determine the effect of hypertension exercise on blood pressure reduction in the Alang - Alang Lebar Puskesmas Work Area in 2019. This research method uses Quasy Experiment with a Non-Equivolent Control Group. The population of this study was all hypertension sufferers in the Work Area of Alang-Alang Lebar Health Center in Palembang in January - March 2019 as many as 84 people. The sample used in this study was a portion of the population, namely some patients with hypertension in the Alang-Alang Lebar Puskesmas Work Area in Palembang totaling 30 respondents. Data analysis uses univariate and bivariate analysis. The results showed an average value of blood pressure in the control group before hypertension was 160.56/100.56 mmHg and the intervention group averaged 159.4/96.6 mmHg. After hypertension gymnastics, the mean blood pressure in the control group was 160/99.44 mmHg and in the intervention group the average value was 136.11/93.89 mmHg. The results of the bivariate analysis revealed that there was an effect of hypertension exercise on the reduction of blood pressure in the Work Area of Palembang Alang-Alang Lebar Health Center in 2019 p value = 0,000. The results of this study can be used as one of the considerations in providing alternative non-pharmacological therapies in non-communicable disease (PTM) programs at the Alang-Alang Lebar Health Center in Palembang.
HUBUNGAN KERASIONALAN PENGGUNAAN ANTIBIOTIK DENGAN PENYAKIT ISPA PADA PASIEN ANAK DI RSUD PALEMBANG BARI TAHUN 2018
Authors: Sapada Edy , Putri Ayu Wandari
Published: July 2021

Infeksi saluran pernafasan akut (ISPA) merupakan masalah kesehatan utama yang banyak ditemukan dan paling sering terjadi pada anak. Tingginya pravelansi penyakit ISPA serta dampak yang ditimbulkan membawa akibat pada tingginya konsumsi obat bebas dan antibiotik. Penelitian ini bertujuan untuk mengetahui hubungan kerasionalan penggunaan antibiotik dengan jenis ISPA yang meliputi tepat diagnosis, tepat indikasi, tepat pemilihan obat, tepat dosis, tepat cara pemberian, tepat interval waktu pemberian, dan tepat kondisi pasien di instalasi rawat jalan di RSUD Palembang BARI tahun 2018. Penelitian ini dilakukan dengan metode non-eksperimental dengan pengambilan data secara retrospektif dengan desain cross-sectional. Sampel penelitian 54 pasien Berdasarkan hasil penelitian diketahui terdapat tepat diagnosis sebesar (100%), tepat indikasi (100%), tepat pemilihan obat (100%), tepat dosis (92,6%), tepat cara pemberian (100%), tepat interval waktu pemberian (96,3%), dan tepat kondisi pasien (100%), serta diperoleh nilai p value 0,317 (p = >0,05) maka tidak terdapat hubungan yang bermakna antara kerasionalan penggunaan antibiotik dengan jenis ISPA pada anak di RSUD Palembang BARI tahun 2018.
PENGARUH AIR RENDAMAN GETAH PEPAYA TERHADAP KEMATIAN JENTIK AEDES AEGYPTI
Authors: Aji Rustam , Sherly FSA  , Rosmawati  , Agus Setya Budi
Published: July 2021

Pemberantasan menggunakan fogging, serbuk abate, yang memiliki efek terhadap lingkungan.Peneliti mencari solusi larvasida alami yang aman dan efektif, Jentik Aedes aegypti yang tidak terpantau akan berkembang menjadi nyamuk dewasa, bisa menyebabkan penyakit Demam Berdarah.  melihat banyaknya tumbuhan  pepaya yang ditanam oleh warga di pekarangan rumah. Tumbuhan pepaya mengandung zat enzim papain, efek protease papain dapat membunuh jentik Aedes aegypti.Penelitian ini bertujuan mengetahui pengaruh air rendaman getah pepaya terhadap kematian jentik Aedes egypti. Lokasi penelitian di Kecamatan Curup Tengah. Jenis quasi eksperimental, analisis Chi-square, menghitung odds ratio, uji Chi kuadrat. Hampir seluruh (94,4%) ada 34 jentik mati dan sebagian kecil (5,5%) ada 2 jentik hidup, dari 36 jentik Aedes aegypti dalam rendaman 50 ml air rendaman getah pepaya waktu dibawah 1 menit. Hasil analisis Chi-square nilaiP value=0.04<α0.05, ada pengaruh yang signifikan antara air rendaman rendaman getah pepaya terhadap kematian jentik Aedes aegypti. Dimana Nilai p value = 0.043, mempunyai pengaruh air rendaman rendaman getah pepaya, pada odds ratio = 4,10 kali.Agar warga masyarakat berperan aktif dalam pemberantasan jentik Aedes aegypti, melalui kegiatan membiasakan menbuat rendaman rendaman getah pepaya dituang kedalam tempat penampungan air.
HUBUNGAN BEBAN KERJA DENGAN KINERJA KARYAWAN DI RUANG FILLING INSTALASI REKAM MEDIS RUMAH SAKIT
Authors: Novianti Nita
Published: July 2021

Workload is a number of jobs that must be completed by a group or someone in a certain time. performance is the result of work that can be achieved by a person or group of people in an organization, in accordance with the authority and responsibility of each in order to achieve organizational goals. The filling room cannot be separated from the medical record officer who works in the room. To maintain the balance of workload with the performance of hospital employees must have special standards so that officers do not feel the workload is not balanced with employee performance. This study aims to determine the relationship between workload and employee performance in the Filling Room for Medical Record Installation at Bhayangkara Hospital, Palembang. The population that became the unit of analysis in the study was employees in the installation of medical records at Bhayangkara Hospital in Palembang with a total sampling technique totaling 16 respondents. The type of research used is quantitative research using the correlation method through the Cross Sectional approach. The data analysis technique used is chi square with SPSS17.0 computer software tools. With the Ha hypothesis test there is a relationship between workload and performance in the filling room of the medical record installation of Bhayangkara Hospital Palembang and H0 there is no correlation between workload and employee performance in the filling room for medical record installation at Bhayangkara Hospital Palembang. Based on the results of the study there was no relationship between workload and employee performance
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL BUAH MAHKOTA DEWA (Phaleria macrocarpa) TERHADAP STAPHYLOCOCCUS AUREUS
Authors: Yunilda Rosa  , Masnir Alwi  , Monica Julianti
Published: July 2021

Phaleria macrocarpa is one of the medicinal plants that many people use as a traditional medicinal which has many benefits, one of which is as a medicine for skin diseases. The content of flavonoid compounds in Phaleria macrocarpa believed to have potential as an antibacterial. The purpose of this study was to know the antibacterial activity of the ethanol extract of the Phaleria macrocarpa to inhibized Staphylococcus aureus bacteria. This research is an experimental study carried out by the liquid dilution method (KHM)and disk diffusion (KBM) of the extract of the Phaleria macrocarpa is divided into 6 concentrations namely 5%, 10% and 15% (KHM) and 40%, 50% and 60% (KBM). The positive control used is clindamycin and the negative control is aquadest. Data analysis uses univariate. Based on observations of the minimum inhibitory concentration of the extract of the fruit of the Phaleria macrocarpa which is at of 15%, while the minimum killed concentration is formed at of 40% with an average of 6.36 mm, and an average of zones formed on the positive control of 9.53 mm. From the results of the study, it was concluded that the extract of the fruit of the Phaleria macrocarpa can inhibit and kill the growth of Staphylococcus aureus bacteria.
An effect of manjistha khadir choorna orally and dermocare oil locally in the management of vicharchika w. s. r. to eczema –a case study.
Authors: Chavan Monica
Published: July 2021

In Ayurveda, majority of skin diseases have been mentioned under the umbrella of Kushthaand in other words ,it can be listed as “Ayurvedic dermatology.” Ayurveda is science of life. Ayurveda is not only curative but also preventive science of life. In ayurveda the word Kushta is broad term which cover almost all skin disorder. Vicharchika is a type of kshudrakushta often encountered by Ayurvedic dermatologists characterized with symptoms namely Kandu (Itching) Srava ( discharge) Pidika (vesicles) and Shayava varna (Discoloration) Rajyo (marked lining due to thickness of lesions) Vicharchika is often correlated to eczema based on the clinical presentations. No satisfactory treatment is available in contemporary medical practice except antihistamines and topical steroids. Mainline of treatment for vicharchika in Ayurved is shodhsna and shaman oushadhi. In spite of the presence of antibiotic, antihistamines, steroids, etc, the skin disorder remains refractory to treatment But Ayurveda is the repository of skin remedies which are therapeutically safe and effectiveness. In present case study is successful ayurvedic management of the case of vicharchika (eczema). Here is case report of a 45 years male having with complaint of padbhagi twak vaivaranyata kandu  pidika ruja rajyo rukshta strava. He was treated with ayurvedic drugs. A remarkable improvement in condition was observed.
Role of Ayurvedic parasurgical procedures in the successful acceptance of graft in non-healing venous ulcer- A Case Study.
Authors: Bhuran Samiksha
Published: July 2021

Venous ulcer is one of the common and difficult to treat cases as it has a high recurrence rate and non-healing nature, failure of graft acceptance, and many agrrevating factors. Treatment is mostly surgical and not affordable to everyone. Many theories were proposed to find the exact cause of the condition and yet it is uncertain. Ayurvedic protocol based treatments helps in treating such conditions thereby improving the agni, bala, satva of such patients along with successful healing. As the treatment is time taking and the patient already has an idea about it, stepwise treatment plays a major role and hence it is a topic were observational studies are required. This paper highlights the role of Ayurvedic protocol in a complicated case with previous surgical histories, failure, and co morbid where amputation and failure of graft was already suggested to the patient previously.
Idiopathic normal pressure hydrocephalus presenting with paroxysmal paraparesis as a cardinal symptom: A case presentation
Authors:   Department of Neurology and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden, Eleftheriou Andreas , Koumantzia Christina ,   Department of Radiology in Linköping, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden
Published: July 2021

Idiopathic normal pressure hydrocephalus (iNPH) is a gradually progressive disease affecting the elderly population. The diagnosis of probable iNPH is based on clinical history, physical findings, brain imaging. INPH involves non-obstructive enlargement of the cerebral ventricles combined with one or more symptoms of cognitive decline, impaired gait and balance, and urinary urgency. Our case describes an unusual coexistence of radiological and clinical iNPH symptoms with paroxysmal paraparesis.
Myelodysplastic syndrome: Discordant involvement of the marrow as observed in the bone marrow biopsy sections
Authors:   Clinical Associate Professor of Medicine, Division of Hematology/Oncology, Department of Medicine, Buffalo General Hospital, Room E 318, Buffalo, New York 14203, USA, Islam Anwarul
Published: July 2021

Myelodysplastic syndromes (MDS) are a diverse group of hematological disorders that affect the blood and bone marrow. Laboratory diagnosis of MDS is almost exclusively based on the morphology of hematopoietic cells observed in smears of peripheral blood and bone marrow and this depends solely on the presence of dysplastic changes observed in the granuloid, erythroid, and megakaryocytic cells [1,2]. Up until now evaluation of sections of bone marrow trephine biopsy specimen did not play a significant role in its diagnosis.
Distinctive COVID-19 manifestations and re-exposure to SARS CoV 2 in clinical laboratory personnel under regular monitoring by RT-PCR and serology
Authors:   Contraprova Diagnósticos, Rio de Janeiro, Brazil, Alonso Fábio de Oliveira Martinez , Sabino Bruno Duarte ,   Contraprova Diagnósticos, Rio de Janeiro, Brazil, Venceslau Marianna Tavares ,   Departament of Preventive Medicine, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Brazil, Varella Rafael Brandão ,   Department of Microbiology and Parasitology, Biomedical Institute, Fluminense Federal University, Brazil
Published: July 2021

Clinical laboratory personnel (CLP) present a unique opportunity to investigate distinct forms of COVID-19 as they are under constant testing for SARS CoV 2 infection. SARS CoV 2 RNA and antibodies were routinely investigated over a 5-month period in 26 professionals from a clinical laboratory in RJ, Brazil. Of them, three (11.5%) CLP presented the following peculiar COVID-19 manifestations: 2/26 (7.7%) had SARS CoV 2 antibodies without RNA detection during the follow-up, with a possible re-exposure in one case, and 1/26 (3.8%) a confirmed reinfection with RNA detection, and possibly a third re-exposure. Based on a long follow-up of SARS CoV 2 infection in CLP, this study showed that cases of COVID-19 without RNA detection are not common, but it does indicate the risk of re-exposure after the fall of antibody levels. Although scarcely reported, the investigation of less frequent forms of COVID-19 is relevant, given the lack of knowledge of its impact on the pandemic.
A rare case of high-grade chondroblastic osteosarcoma post-radiotherapy for a right frontal oligodendroglioma
Authors:   Beaumont Hospital, Ireland, Horan Sinead , Breathnach Oscar ,   Beaumont Hospital, Ireland, Grogan Liam ,   Beaumont Hospital, Ireland, Fitzpatrick David ,   Beaumont Hospital, Ireland, Morris Patrick ,   Beaumont Hospital, Ireland, Naidoo Jarushka ,   Beaumont Hospital, Ireland, Rangaswamy Guhan ,   Beaumont Hospital, Ireland, Quinn Marion ,   Beaumont Hospital, Ireland, Brett Francesca ,   Beaumont Hospital, Ireland, Beausang Alan ,   Beaumont Hospital, Ireland, Murphy Adrian ,   Beaumont Hospital, Ireland
Published: July 2021

This is the fourteenth case of an intracranial and dural-based osteosarcoma in the literature to date. The case involves a forty-year old woman with a previous history of a brain tumour, which was treated with surgery, chemotherapy and radiotherapy six years previously. The hypothesis is that this rare malignancy is secondary to the radiation exposure given the growth of the lesion in the previous radiation field
A rare entity of non-filarial lymphedema
Authors:   Penn State College of Medicine, Hershey, Pennsylvania, USA, Stauch Christopher , Jafari Moein ,   Penn State College of Medicine, Hershey, Pennsylvania, USA, Polimera Hyma ,   Penn State College of Medicine, Hershey, Pennsylvania, USA
Published: July 2021

Patient is a 77 year old female who presented to the outpatient dermatology clinic due to progressive massive leg swelling. Physical exam demonstrated bilateral lower extremity chronic lymphedema with stasis dermatitis changes with the left more significant than the right. The patient was diagnosed with elephantiasis nostras verrucosa (ENV) and was treated with leg elevation and arranged for follow-up with a chronic lymphedema clinic. ENV is a rare complication of non-filarial chronic lymphedema. Its pathogenesis is characterized by long-standing lymphatic obstruction, which may occur due to a variety of obstructive diseases. This can lead to accumulation of proteinaceous fluid in the dermis and subcutaneous tissues causing further lymphatic obstruction and edema followed by hyperkeratosis, fibrosis, and formation of papillated, verrucous papules. Differential diagnoses to consider include venous stasis dermatitis, cellulitis, lipodermatosclerosis, pretibial myxedema, and lymphatic filariasis. Mainstays of treatment of ENV include elevation of the affected body part, compressive hosiery, and antibiotic prophylaxis for superimposed infection [1].
Neurological manifestations in glutaric acidemia type 1 and the impact of expanded neonatal screening in Brazil
Authors:   Department of Pediatrics, Hospital Materno Infantil de Brasília (HMIB), Brazil, Borges Ada Maria Farias Sousa , Garcia Romina Soledad Heredia ,   Department of Genetics, Hospital Materno Infantil de Brasília (HMIB), Brazil
Published: July 2021

Glutaric acidemia type 1 (GA1) is an inborn error of metabolism caused by the deficiency of the enzyme glutaryl-CoA dehydrogenase, with consequent accumulation of the aminoacids lysine, hydroxylsine and tryptophan. About 1 in every 100,000 individuals are affected by the disease. Neurological manifestations are variable and include acute and chronic encephalopathic crises, dystonia, motor and cognitive deficits, as well as neuroimaging findings such as brain hypoplasia, striatal, white matter and subdural effusions. Early diagnosis is crucial for specific therapy, which includes a diet with restricted amino acids and carnitine replacement. The present work describes the variability of neurological manifestations in four patients with glutaric acidemia type 1, diagnosed in different age groups, through mass spectrometry, technology of the expanded neonatal screening available in the Ministry of Health program in Federal District, Brazil. Complications of GA1 were more severe in cases with later diagnosis, which justifies the use of the enlarged neonatal screening as an important resource in the early diagnosis and treatment of inborn errors of metabolism.
Re-plantation of avulsed permanent incisor after 4 days of trauma
Authors:   Department of Pedodontics, Damascus University, Syria, Alomari Haya , Kouchaji Chaza ,   Department of Pedodontics, Damascus University, Syria
Published: July 2021

Tooth avulsion in children and adolescents demands urgent treatment to enhance the chances of successful re-implantation. This case report describes the treatment of an 11-year-old girl who suffered an avulsion of the maxillary right central incisor followed by delayed re-implantation after the tooth was stored in a dry medium for 4 days. Although the tooth was kept in unfavorable conditions, tooth reimplantation was done because the patient was young and it was advantageous to avoid psychological harm as well as esthetic and functional issues.
The interference of laboratory tests by immunoglobulin infusion: Problems and solutions
Authors:   Central Sydney Immunology Laboratory at Royal Prince Alfred Hospital, NSW Health Pathology, Sydney, Australia, Chen Renfen , Wei Xiumei ,   Sutherland Centre of Immunology, NSW Health Pathology, Sydney, Australia
Published: July 2021

Intravenous Immunoglobulin (IVIG) has been increasingly used in managing a variety of immune-mediated conditions. While patients benefit from this treatment, the infusion of IVIG has transmitted large variety of antibodies and biological agents from donors to patients, and transiently interfered a broad spectrum of clinical laboratory tests covering the fields of infectious and autoimmune serology, biochemistry, haematology and blood bank, delivering spurious results that could potentially cause extensive evaluation and inappropriate clinical interventions. The medical practitioners and laboratory professionals must improve the awareness of test interferences caused by IVIG infusion. Proactive actions and appropriate strategy for investigating and interpreting the affected laboratory tests must be taken to avoid adverse impact on patient’s care.
Morphological patterns of anemia among under five children on Prevention of Mother-To-Child Transmission (PMTCT) programmes in Masogo sub-county hospital, Kisumu county, Kenya
Authors:   Ministry of Health, Masogo sub-county hospital, Kisumu County, 12-40122 Kisumu, Kenya, Awuor Silas O , Eric Omwenga O ,   School of Health Sciences, Kisii University, 408-40200 Kisii, Kenya, Musyoki Stanslaus ,   School of Health Sciences, Kisii University, 408-40200 Kisii, Kenya, Daud Ibrahim I ,   Kenya Medical Research Institute, United States Army Medical Research Directorate-Africa, HJF Medical Research International, Kericho, Kenya, Nyangaresi Robert O ,   Ministry of Health, Masogo sub-county hospital, Kisumu County, 12-40122 Kisumu, Kenya, Mugah Peter ,   Ministry of Health, Masogo sub-county hospital, Kisumu County, 12-40122 Kisumu, Kenya, Mukunzi Beatrice ,   Ministry of Health, Masogo sub-county hospital, Kisumu County, 12-40122 Kisumu, Kenya
Published: July 2021

Background: Anaemia during childhood adversely affects mental, physical and social development of the children, therefore morphological patterns of anaemia in under- five children are considered essential for classification, diagnosis and management. Aim: This study aimed at assessing morphological patterns, the prevalence and associated factors of anaemia among under-five children on Prevention of Mother-To-Child Transmission (PMTCT) programmes in Masogo sub-county hospital, Kisumu County, Kenya. Method: A cross-sectional health facility-based study was conducted among 175 children aged 6 to 59 months who attended clinic for the PMTCT programme for the period of January 2020 to December 2020. Pretested and structured questionnaires were used to collect socioeconomic and demographic characteristics of the family and child. Capillary blood sample was collected from each child for malaria parasite and Peripheral Blood Film (PBF) examination. Result: Complete blood counts indicate that microcytic pattern was the most common, representing 30 (42.3%) followed by microcytic hypochromic pattern 20 (28.2%), normocytic normochromic pattern with 11 (15.5%) and lastly dimorphic pattern with 10 (14.0%). High prevalence of anaemia was observed in children who were urban dwellers (50.0%), in children whose mothers aged 18-27 years (44.0%) and had no formal education (48.1%). Besides, the high prevalence rate of anaemia was found among children with a family monthly income of less than 500 Ksh. (46.9%), early (<6 months) introduction of complementary foods (71.4%). Conclusion: This study has revealed that the prevalence of anaemia in children less than five years is high and is a severe public health problem in the study area. Therefore, the policymakers should make a strategy that can reduce poverty and increase the awareness to women on breastfeeding, nutrition, and other associated factors to reduce anaemia.
Thyroglossal duct cyst presenting as life-threatening airway obstruction in a neonate
Authors:   Pediatric Endocrinology and Diabetes Unit, Dana-Dwek Children’s Hospital, Israel, Hejla Duha , Elkon-Tamir Erella ,   Pediatric Endocrinology and Diabetes Unit, Dana-Dwek Children’s Hospital, Israel, Pratt Li-tal ,   Pediatric Radiology Unit, Dana-Dwek Children’s Hospital, Israel, Wasserzug Oshri ,   Pediatric ENT Unit, Dana-Dwek Children’s Hospital, Israel, Leider-Trejo Leonor ,   Institute of Pathology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, Brener Avivit ,   Pediatric Endocrinology and Diabetes Unit, Dana-Dwek Children’s Hospital, Israel, Lebenthal Yael ,   Pediatric Endocrinology and Diabetes Unit, Dana-Dwek Children’s Hospital, Israel
Published: July 2021

Thyroglossal duct cysts are the most common congenital abnormality in the neck, accounting for 70-75% of midline neck masses in children [1]. Late in the 4th week of gestation, the thyroid anlage develops as a small, solid mass of endoderm proliferating at the foramen cecum. As the thyroid anlage descends caudally in the neck, it maintains an attachment to the site of origin at the level of the foramen cecum of the tongue via the thyroglossal duct [2]. The thyroglossal duct typically involutes and atrophies between 7 and 10 weeks of gestation by the time the thyroid gland reaches its final position inferior to the cricoid cartilage [2]. The source of TGDC is believed to be persistent remnants of the thyroglossal duct. Due to the communication of the duct to the mouth via the foramen cecum, thyroglossal cysts can become infected with oral flora. One-third of patients of all ages will present with a concurrent or prior infection, and one-quarter will present with a draining sinus from spontaneous or incisional drainage of an abscess [3]. The cysts occur almost equally in both sexes [4,5].
Localized psoriasis post hand burn
Authors:   Department of Dermatology, University Hospital center Hassan II, Faculty of Medecine, University Sidi Mohammed Ben Abdellah, Fez, Morocco, Elloudi Sara , Kamli Noura ,   Department of Dermatology, University Hospital center Hassan II, Faculty of Medecine, University Sidi Mohammed Ben Abdellah, Fez, Morocco, Mernissi Fatima Zahra ,   Department of Dermatology, University Hospital center Hassan II, Faculty of Medecine, University Sidi Mohammed Ben Abdellah, Fez, Morocco
Published: July 2021

The Koebner Phenomenon (KP) is the appearance of new skin lesions on previously unaffected skin secondary to trauma. This phenomenon is given the fact that the new lesions that appear are clinically and histologically identical to the patient’s underlying cutaneous disease [1].
Primary leiomyosarcoma of femur: A rare entitycase report and review of literature
Authors:   Department of Pathological Anatomy and Cytology, Fattouma Bourguiba University Hospital, Monastir, Tunisia, Abdeljelil Nouha Ben , Mabrouk Asma Ben ,   Department of Pathological Anatomy and Cytology, Fattouma Bourguiba University Hospital, Monastir, Tunisia, Bellalah Ahlem ,   Department of Pathological Anatomy and Cytology, Fattouma Bourguiba University Hospital, Monastir, Tunisia, Njima Manel ,   Department of Pathological Anatomy and Cytology, Fattouma Bourguiba University Hospital, Monastir, Tunisia, Hadhri Rim ,   Department of Pathological Anatomy and Cytology, Fattouma Bourguiba University Hospital, Monastir, Tunisia, Zakhama Abdelfattah ,   Department of Pathological Anatomy and Cytology, Fattouma Bourguiba University Hospital, Monastir, Tunisia
Published: July 2021

Background: We report this case to highlight clinical and pathological features of this rare entity. Methods: It is about a 48 year-old woman with an osteolytic lesion of the lower extremity of the left femur. Result: A biopsy of the lesion showed densely cellular malignant mesenchymal proliferation. It was made by bundles of smooth muscle cells with nuclei of moderate to severe atypia. The immunohistochemical study showed an intense and diffuse cytoplasmic positivity of tumor cells with the smooth anti-muscle. Desmin was focal positive. After neoadjuvant chemotherapie, a knee block resection was made. Macroscopically, it was a 10 cm sized tumor located in the distal part of tumor. Histologically tumor showed post chemotherapy effects estimated at 20%. The bone and muscle surgical limits were unscathed. Conclusion: Primary leiomyosarcoma of bone is a rare and a diagnostically challenging tumor entity.
Ultrasound guided femoral artery cannulation: A key point for security
Authors:   University Hospital of the Santa Fe de Bogotá Foundation, Anesthesia, Colombia, Claudia Niño , Nicolas Useche ,   University Hospital of the Santa Fe de Bogota Foundation, Radiology, Colombia, William Amaya-Zuñiga ,   University Hospital of the Santa Fe de Bogotá Foundation, Anesthesia, Colombia
Published: July 2021

Some meta-analyses have shown the broad benefits of the ultrasound visualization for arterial cannulation, such as the increases of the first-attempt success rate, mean attempts, meantime, and reduction of hematoma incidence. The advantages over the palpation technique, promote the inclusion of ultrasound guide as part of the recommendation for arterial cannulation [1].
Primary strumal carcinoid tumor of the ovary arising from a heterochronous struma ovarii in young female patient
Authors:   Department of Pathology and Laboratory Medicine, Taoyuan Armed Forces General Hospital, Taoyuan City, Taiwan, R.O.C, Liu Kuang-Ting , Chang Yueh-Ching ,   Department of Pathology and Laboratory Medicine, Taoyuan Armed Forces General Hospital, Taoyuan City, Taiwan, R.O.C, Lin Yu-Chieh ,   Department of Pathology, Tri-Service General Hospital, Teipai City, Taiwan, R.O.C, Chang Junn-Liang ,   Department of Pathology, Tri-Service General Hospital, Teipai City, Taiwan, R.O.C
Published: July 2021

Primary ovarian carcinoid tumors are extremely rare. Ovarian strumal carcinoid is usually derived from mature cystic teratoma, an ovarian germ cell tumor composed of two distinctive components characteristic thyroid tissue intermixed with a carcinoid tumor. The incidence of stromal carcinoid tumor is accounting for 0.3-1% of all ovarian tumors and 3% of all mature teratomas. Herein, we report a 25-year-old female presented with severe abdominal pain. She had right struma ovarii after Laparoscopic-Assisted Ovarian Cystectomy (LAOC) procedure one year ago. The sonography of abdomen images study demonstrated a well capsulated cystic mass measured up to 11 cm in dimension. The mature cystic teratoma was the first diagnostic possibility. She underwent the laparoscopy-assisted left ovarian cystectomy. Histopathological and immunohistochemical examinations confirmed strumal Carcinoid Tumor of the Ovary (SCTO) arising from strum ovarii in the left ovary. She was recovered well and was still asymptomatic after two years follow-up. In conclusion, we first describe the primary SCTO arising from a heterochronous struma ovarii. The symptoms of SCTO are usually non-specific and misleading. Therefore, it is important to fully understand the characteristics, diagnosis and management of SCTO. Diagnosis should be confirmed by pathology and immunohistochemistry, and clinically metastatic carcinoid should be excluded.
3D preoperative assessment for locally advanced pancreatic cancer undergoing modified-Appleby procedure with reversed autologous arterial graft reconstruction: A case report
Authors:   General Surgery Unit, Ospedale di Vimercate, ASST Brianza, Via Santi Cosma e Damiano 10, 20871, Vimercate, Ital, Cotsoglou Christian , Granieri Stefano ,   General Surgery Unit, Ospedale di Vimercate, ASST Brianza, Via Santi Cosma e Damiano 10, 20871, Vimercate, Ital, Paleino Sissi ,   General Surgery Unit, Ospedale di Vimercate, ASST Brianza, Via Santi Cosma e Damiano 10, 20871, Vimercate, Ital, Chierici Andrea ,   General Surgery Unit, Ospedale di Vimercate, ASST Brianza, Via Santi Cosma e Damiano 10, 20871, Vimercate, Ital
Published: July 2021

Advanced pancreatic ductal adenocarcinoma represents one of the most challenging oncologic diseases nowadays for many reasons: it is burdened by one of the poorest prognoses, it is often diagnosed when in an advanced stage and it demands a multimodal approach which is necessary to assign the proper patient-specific treatment. When feasible, surgical resection combined with systemic treatment is still the best curative choice and can require complex vascular resections and reconstructions to obtain R0 margins. In these cases, a detailed preoperative assessment made of blood tests, thoracoabdominal imaging and histological definition of the tumor is fundamental. Unfortunately, the current imaging techniques are not completely reliable in defining the extension of the contact between the neoplasm and the surrounding arteries and veins, especially when considering borderline and locally advanced diseases. The use of 3D reconstructions can improve the perception of crucial anatomical details for the diagnostic evaluation and the surgical procedure.
Reinfection of SARS-CoV-2 in a health care worker: A case report
Authors:   Division of Infection Control and Infectious Diseases, Medical Faculty, RWTH Aachen University Hospital, Aachen, Germany, Höring Steffen , Keller Doris ,   University Medical Center for Occupational Medicine, RWTH University, Aachen, German, Kleines Michael ,   Laboratory Diagnostic Center, RWTH Aachen University Hospital, Aachen, Germany
Published: July 2021

Coronavirus-specific antibodies decline fast and allow reinfection starting 6 months post infection. Knowledge on reinfection is very important for SARS-CoV-2. Here we report a reinfection with SARS-CoV-2 of a 23 years old female health care worker 177 days after the onset of the first episode. The second episode was clinically more severe as the first episode. Our data show that reinfection with SARS-CoV-2 can occur with increased clinical impact in immunocompetent, young individuals after less than half a year.
Functional outcomes in women with neurological complications secondary to oral contraceptive pills: A case series
Authors:   Department of Physical Medicine & Rehabilitation, St. John`s National Academy of Health Sciences, Sarjapura road, Bengaluru, Karnataka-560034, India., Rawat Nidhi , Charls Anit Catherine ,   Department of Physical Medicine & Rehabilitation, St. John`s National Academy of Health Sciences, Sarjapura road, Bengaluru, Karnataka-560034, India.
Published: July 2021

Cerebrovascular complications of Oral Contraceptive Pills (OCPs) are recorded in literature. We present a case series of 4 women who were admitted in the Department of Physical Medicine and Rehabilitation after having cerebrovascular complications. The only risk factor which was identified was the history of OCPs intake. The cerebrovascular accident ranged from arterial stroke to cerebral venous thrombosis (CVT-3, arterial stroke-1). All of them underwent rehabilitation for 3 weeks. Two out of three CVT patients had good functional recovery. A targeted rehabilitation program during the early phase of the condition results in better functional outcome in patients.
Severe herpes-simplex-virus-1-reactivation during severe SARS-CoV-2 infection
Authors:   Department of Anaesthesiology and Critical Care, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Germany, Kalbhenn Johannes , Zieger Barbara ,   Department of Anaesthesiology and Critical Care, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Germany, Casetti Federica ,   Department of Anaesthesiology and Critical Care, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Germany
Published: July 2021

We present the case of a 59-year-old female patient with severe Coronavirus Acute Respiratory Distress Syndrome (CARDS) admitted to Intensive Care Unit (ICU). Prior to the SARS-CoV-2 infection she had no other medical problems besides chronic arterial hypertension. Endotracheal intubation became necessary. Between five episodes of therapeutic prone positioning during the mechanical ventilation, swelling of the lower lip was observed. Local pressure ulcer caused by the endotracheal tube and lip edema were suspected and treated with dexpanthenol ointment. Sweeling increased and a cluster of inflamed vesicles appeared on the lower lip, rapidly affecting the whole labial region, chin and décolleté.
Concomitant chromosome 5q-deletion and JAK2V617F mutation present with myelodysplastic and myeloproliferative overlap features
Authors:   Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA, Miotke Laura , Patel Jay ,   Department of Pathology ARUP Laboratories, University of Utah, Salt Lake City, UT, USA., Prchal Josef T ,   Division of Hematology and Hematologic Malignancies, Huntsman Cancer Hospital, University of Utah, Salt Lake City, UT, USA., Tantravahi Srinivas K ,   Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA
Published: July 2021

Myelodysplastic Syndrome (MDS) with an isolated deletion of chromosome 5q [del(5q)] is a relatively rare MDS variant (5%) characterized by a moderate to severe anemia and normal or elevated platelet count with modest neutropenia [1-3]. These latter features, in addition to its excellent response to lenalidomide, are likely what contribute for its favorable prognosis [3-5]. The somatic gain of function mutation in JAK2 V617F is a driving mutation in Myeloproliferative Neoplasms (MPN), occurring in 97% of polycythemia vera (PV), 50-60% of essential thrombocytosis (ET) and primary myelofibrosis (PMF) [6]. This mutation results in constitutive activation of the JAK-STAT signaling pathway leading to increased proliferation and hypersensitivity to cytokines erythropoietin, IL-3, thrombopoietin, and GCSF. An allelic burden of JAK2 V617F mutation correlates with an increased risk of thrombosis and hemorrhage, as well as secondary fibrosis in MPN patients [7].
Lateral sliding flap for one-step reconstruction of medium-sized eyelid defects
Authors:   The Rotterdam Eye Hospital, Oculoplastic & Orbital Service, Rotterdam, Netherlands., Paridaens Dion
Published: July 2021

Background/purpose: To report the results of our clinical study on the efficacy of a ‘Lateral Sliding Flap’: A one-step technique for lower or upper eyelid reconstruction. Methods: Retrospective analysis of a consecutive case series of patients treated with a ‘Lateral Sliding Flap’ following tumour removal by horizontal block excision. In this technique a (medium-sized) defect of up to 50% of the eyelid was reconstructed by disinsertion of the lateral canthus, medial advancement of the lateral (remaining) (full-thickness) eyelid and a laterally-based horizontal skin-muscle advancement flap, followed by canthal fixation. We recorded the operating time and evaluated the postoperative eyelid apposition, lid contour, complications and frequency and type of re-operation. The outcome was scored (according to four grades (excellent/good/fair/ poor) of lid apposition and contour. Results: Seven consecutive patients, all treated by one oculoplastic surgeon in one year, were included. Six were female, one was male. Five had lower eyelid defects, two had upper eyelid defects of 40-50% of the horizontal width. The average age was 67,9 years, ranging from 52 to 85 years. The mean postoperative follow-up time was 31 months, ranging from 21-43 months. The average duration of the reconstruction was 31 minutes (ranging from 25 to 38 minutes). The outcome was excellent in 3 patients, good in 3 patients and fair in one patient. (Some) lash loss may be encountered. No complications such as flap ischemia of necrosis were noted. No re-operation was required. Conclusion: The ‘Lateral Sliding Flap’ is an efficaceous, one-step technique for reconstruction of defects of up to 50% of the lower or upper eyelid. With the technique a normal eyelid margin is created at the level of the cornea for optimal visual function and comfort. Compared to Tenzel’s semicircular rotation flap, the ‘lateral sliding flap’ results in a shorter vertical scar and “Hidden” horizontal scars in the relaxed skin tension lines.
Chest CT surprising improvement in COVID-19 patient
Authors:   Internal Medicine, ASST Fatebenefratelli Sacco, Milano, Department of Biomedical and Clinical Sciences, University of Milan, Italy., Calabrò Elisa , Gabiati Claudia ,   Internal Medicine, ASST Fatebenefratelli Sacco, Milano, Department of Biomedical and Clinical Sciences, University of Milan, Italy., Nucera Gabriella ,   UOC Medicina D’Urgenza, ASST Fatebenefratelli Sacco, Milano, Italy., Raffaelli Valentina ,   UOC Medicina D’Urgenza, ASST Fatebenefratelli Sacco, Milano, Italy., Bombaci Francesco ,   Radiology Department, ASST Fatebenefratelli Sacco, Milano, Italy., Brucato Antonio ,   Internal Medicine, ASST Fatebenefratelli Sacco, Milano, Department of Biomedical and Clinical Sciences, University of Milan, Italy.
Published: July 2021

A surprising improvement in COVID-19 chest CT follow up gives hope regarding future clinical evolution of COVID-19 patients.
A unique association of diaphragmatic hernia and pulmonary tuberculosis in an infant
Authors:   Department of Pediatrics, First Faculty of Medicine, Charles University and Thomayer University Hospital in Prague, Czech Republic., Dolezalova Karolina , Bloomfield Marketa ,   Department of Pediatrics, First Faculty of Medicine, Charles University and Thomayer University Hospital in Prague, Czech Republic., Magner Martin ,   Department of Pediatrics, First Faculty of Medicine, Charles University and Thomayer University Hospital in Prague, Czech Republic.
Published: July 2021

We report a healthy-appearing 7-month-old girl of non-related ancestry, uneventful pre - and postnatal development and past medical history, who was investigated for lung Tuberculosis (TB) in her mother. Tuberculin skin test was highly positive (20 mm induration, normal range 0-5 mm in unvaccinated children). Chest X-ray (CXR) revealed a surprising image suggestive of the presence of abdominal contents in the thoracic cavity (Figure 1); the unobscured lung parenchyma showed no signs of TB.
Laparoscopic intermediate gastrectomy for treatment of non metastatic gastric gastrointestinal stromal tumors located at the posterior wall and lesser curvature
Authors:   Department of General Surgery of AUSL Toscana Centro, Santa Maria Annunziata Hospital, Florence, Italy, Marcucci Tommaso , Falsetti Elena ,   Department of General Surgery of AUSL Toscana Centro, Santa Maria Annunziata Hospital, Florence, Italy, Genzan Chiara ,   Department of General Surgery of AUSL Toscana Centro, Santa Maria Annunziata Hospital, Florence, Italy, Pandolfini Lorenzo ,   Department of General Surgery of AUSL Toscana Centro, Santa Maria Annunziata Hospital, Florence, Italy, Laessig Romana ,   Department of General Surgery of AUSL Toscana Centro, Santa Maria Annunziata Hospital, Florence, Italy, Paroli Gian Matteo ,   Department of General Surgery of AUSL Toscana Centro, Santa Maria Annunziata Hospital, Florence, Italy, Scatizzi Marco ,   Department of General Surgery of AUSL Toscana Centro, Santa Maria Annunziata Hospital, Florence, Italy
Published: July 2021

Gastrointestinal Stromal Tumors (GISTs) are rare neoplasms but they represent the most common type of mesenchymal tumors found in the Gastrointestinal (GI) tract [1-5]. GISTs arise from the interstitial cells of Cajal, “Pacemaker Cells”, that play a neuromotor role in normal gut motility [3,6]. They account for < 1% of gastrointestinal tumors with an estimated annual incidence of 10 to 20 cases for one million of the general population [1,2]. Treatment has not yet been standardized, but surgical resection remains the mainstay for non-metastatic GISTs [5]. The use of laparoscopic techniques has been widely debated.
Skull metastasis originating from adenocarcinoma of the esophagogastric junction
Authors:   First Propedeutic Department of Surgery, National and Kapodistrian University of Athens, Hippocration Hospital, 114 Vasilissis Sofias Avenue, 11527 Athens, Greece., Despina Kimpizi , Tania Triantafyllou ,   First Propedeutic Department of Surgery, National and Kapodistrian University of Athens, Hippocration Hospital, 114 Vasilissis Sofias Avenue, 11527 Athens, Greece., Dimitrios Theodorou ,   First Propedeutic Department of Surgery, National and Kapodistrian University of Athens, Hippocration Hospital, 114 Vasilissis Sofias Avenue, 11527 Athens, Greece.
Published: July 2021

Esophageal carcinoma usually metastasizes to the liver, distant lymph nodes and lungs. The histological subtype may influence the metastatic sites, with bone metastasis being rather uncommon. This is a report on a patient who presented with adenocarcinoma of the esophagogastric junction and a concurrent skull metastasis.
Sebaceous gland extrusion
Authors:   Pathology Laboratory, CITADIAG SL, c/ Amor de Dios 17 a, loc B, 41002, Sevilla, Spain., Torres-Gómez Francisco Javier T , Medina-González Rosa Sánchez de ,   Pathology Laboratory, CITADIAG SL, c/ Amor de Dios 17 a, loc B, 41002, Sevilla, Spain.
Published: July 2021

The extrusion of a sebaceous gland through a follicular infundibulum is a rare dermatopathology image that raises two fundamental questions: Is it an artifact?. Can a full gland be expelled just as its secretion does?. The answer is not easy and there are no bibliographic references to help us solving the doubt. These two images correspond to the case of an 18-year-old male patient who consulted for a rapidly evolving yellowish nummular lesion on the cheek. An oily secretion was released from it.
Early childhood caries among premature children enrolled in WIC: A retrospective case - Controlled study
Authors:   Adjunct professor, Department of Pediatric Dentistry, The University of Iowa Colelge of Dentistry and Dental Clinics, Iowa City, IA, Christensen Alison R ,   and a Dentist in Private Practice, West Des Moines and Waukee, IA, USA., Qian Fang ,   Associate Research Scientist, Division of Biostatistics and Computational Biology and Department of Preventive and Community Dentistry, The University of Iowa College of Dentistry and Dental Clinics, Iowa City, IA, USA., Weber-Gasparoni Karin ,   Professior and Head, Department of Pediatric Dentistry, The University of Iowa College of Dentistry and Dental Clinics, Iowa City, IA, USA.
Published: July 2021

Purpose: To investigate the association between premature birth and Early Childhood Caries (ECC) experience, while secondarily evaluating factors that may influence development of caries. Methods: Data collected from patients enrolled at the University of Iowa’s Infant Oral Health Program consisted of prenatal history, child’s demographics, neonatal history, oral hygiene, dietary habits, and clinical findings (visible plaque, enamel defects, and caries). Bivariate and logistic regression analyses were utilized (alpha=0.05). Results: Four hundred and ninety eight randomly matched premature and full-term subjects were included (mean age=21 months [range: 6-71 months]; 51.4% males and 38.9% African Americans). Bivariate analysis revealed no significant differences existed regarding cavitated and non-cavitated caries experience between full-term and premature subjects. Additionally, compared to their counterparts, premature subjects were more likely to eat cariogenic snacks between meals (P=0.028), drink cariogenic beverages >2 times per day (P=0.027), not have their teeth brushed daily (P<0.001), and less likely to have seen a dentist (P=0.04). Logistic regression analysis showed that showed number of teeth present (OR=1.24, 95% CI: 1.10-1.39 ; P<0.001) and visible plaque on maxillary incisors (OR=5.69, 95% CI: 2.22-14.55; p<0.001) to be significantly associated with ECC in premature subjects. Conclusions: While there was no evidence that prematurity was associated with ECC, premature subjects had cariogenic dietary behaviors and high-risk oral hygiene behaviors.
Nuclear odontology: Pictorial essay
Authors:   Nuclear Medicine Division, Department of Radiology and Medical Imaging, King Khalid University Hospital and College Of Medicine, King Saud University, 7805(46), Riyadh 11472 - Saudi Arabia., Othman Saleh A
Published: July 2021

There is increased demand by the general dentist and oral surgeon’s for Nuclear Medicine (NM) imaging procedures both for initial diagnosis and follows up of patients with different dental and facial disorders. There are several procedures in NM including bone scan, gallium scan and PET scan which can offer important diagnostic information complementing the information obtained from other imaging modalities in particular a better understanding of the pathophysiology of the disease and therapy monitoring.