bluuebunny/crossref_metadata_2025 huggingface dataset:
Histologically confirmed upper gastrointestinal Crohn’s disease: is it rare or are we just not searching hard enough?
Authors: Saadah Omar Ibrahim , Fallatah Kholoud Bakur , Baumann Cedric , Elbaradie Abdulrahman Ahmed , Howladar Fatimah Talat , Daiwali Motaz Tariq , Alshuaibi Omar Hamad , Alsahafi Majid Abdulaziz , Bokhary Rana Yaqoob , Qari Yousef Abdulfattah , Peyrin-Biroulet Laurent , Mosli Mahmoud Hisham
Published: February 2020

Background/Aims: Crohn’s disease (CD) may involve the upper parts of the gastrointestinal (GI) tract including the esophagus, stomach, and duodenum. Clinical features of upper GI CD (UGICD) are not well characterized in the Gulf region. We therefore aimed to assess the prevalence and clinical characteristics of patients diagnosed with UGICD.Methods: We performed a retrospective analysis of all patients diagnosed with CD who underwent upper GI endoscopy between 2012 and 2017 at King Abdulaziz University Hospital, irrespective of age. Patients who had endoscopy of the upper GI tract at baseline and had histologically confirmed UGICD were included. Data on patients’ demographics, clinical characteristics, extraintestinal manifestations and complications were reviewed.Results: We identified 78 CD patients who underwent upper GI endoscopy from our medical records. The mean age was 17.2±8.7 years and 55.1% were males. Of the total, 19 out of 78 patients (24.4%) had histologically confirmed UGICD (3 esophageal, 16 gastric, and 9 duodenal), of which 52.6% were symptomatic. Disease distribution was ileal in 57.8%, colonic in 21.1% and ileo-colonic in 21.1%. A non-stricturing and non-penetrating phenotype was reported in 89.4%, stricturing in 5.3%, and penetrating in 5.3%. Perianal disease was found in 10.5%. UGICD was complicated by stricture formation in 2 patients (esophageal and gastric).Conclusions: The prevalence of UGICD is considered high among CD Saudi patients who undergo upper GI endoscopy at baseline, and is asymptomatic in 47.4% of patients. This reported prevalence is not dissimilar from reports originating from Western countries.
Hypermethylated promoters of tumor suppressor genes were identified in Crohn’s disease patients
Authors: Kim Tae-Oh , Han Yu Kyeong , Yi Joo Mi
Published: February 2020

Background/Aims: Overwhelming evidence suggests that inflammatory bowel disease (IBD) is caused by a complicated interplay between the multiple genes and abnormal epigenetic regulation in response to environmental factors. It is becoming apparent that epigenetic factors are significantly associated with the development of the disease. DNA methylation remains the most studied epigenetic modification, and hypermethylation of gene promoters is associated with gene silencing.Methods: DNA methylation alterations may contribute to the many complex diseases development by regulating the interplay between external and internal environmental factors and gene transcriptional expression. In this study, we used 15 tumor suppressor genes (TSGs), originally identified in colon cancer, to detect promoter methylation in patients with Crohn’s disease (CD). Methylation specific polymerase chain reaction and bisulfite sequencing analyses were performed to assess methylation level of TSGs in CD patients.Results: We found 6 TSGs (sFRP1, sFRP2, sFRP5, TFPI2, Sox17, and GATA4) are robustly hypermethylated in CD patient samples. Bisulfite sequencing analysis confirmed the methylation levels of the sFRP1, sFRP2, sFRP5, TFPI2, Sox17, and GATA4 promoters in the representative CD patient samples.Conclusions: In this study, the promoter hypermethylation of the TSGs observed indicates that CD exhibits specific DNA methylation signatures with potential clinical applications for the noninvasive diagnosis of IBD and the prognosis for patients with IBD.
Leucoagaricus brunneus sp. nov. from Khyber Pakhtunkhwa, Pakistan
Authors: Ullah Zia , Jabeen Sana , Faisal Muhammad , Ahmad Habib , Khalid Abdul Nasir
Published: February 2020

A field survey of macrofungi from the Hindu Kush range of District Swat revealed a fungus morphologically similar to Leucoagaricus but representing a new species, here named L. brunneus. A detailed description and comparison with closely allied taxa are provided. Maximum
likelihood analysis based on the internal transcribed spacer rDNA region (ITS) confirm its placement in Leucoagaricus sect. Rubrotincti .
Rhomboidia wuliangshanensis gen. & sp. nov. from southwestern China
Authors: Xu Tai-Min , Liu Xiang-Fu , Chen Yu-Hui , Zhao Chang-Lin
Published: February 2020

A new, white-rot, poroid, wood-inhabiting fungal genus, Rhomboidia, typified by R. wuliangshanensis, is proposed based on morphological and molecular evidence. Collected from subtropical Yunnan Province in southwest China, Rhomboidia is characterized by annual,
stipitate basidiomes with rhomboid pileus, a monomitic hyphal system with thick-walled generative hyphae bearing clamp connections, and broadly ellipsoid basidiospores with thin, hyaline, smooth walls. Phylogenetic analyses of ITS and LSU nuclear RNA gene regions showed that Rhomboidia
is in Steccherinaceae and formed as distinct, monophyletic lineage within a subclade that includes Nigroporus, Trullella, and Flabellophora .
Sarcopodium flocculentum, the correct name for S. macalpinei
Authors: Pennycook Shaun R. , Kirk Paul M.
Published: February 2020

The nomenclatural background of the species treated as Sarcopodium macalpinei is briefly outlined, and the requirement to supersede that name with a combination based on Nectriella flocculenta [≡ Lanatonectria flocculenta] is explained.
Checklist of Bolivian Agaricales. 1: Species with dark and pink spore prints
Authors: Melgarejo-Estrada E. , Suárez M.E. , Rocabado D. , Maillard O. , Lechner B.E.
Published: February 2020

Mycotaxon is pleased to add a new annotated species distribution list to our 134 previously posted free access fungae. The 22-page "Checklist of Bolivian Agaricales. 1: Species with dark and pink spore prints." by E. Melgarejo-Estrada, M.E. Suárez, D. Rocabado, O. Maillard,
and B.E. Lechner may be downloaded from our website via http://www.mycotaxon.com/mycobiota/index.html
The Degree of the Practice of Ma'an Governorate Teachers for the Skills of Building Achievement Tests
Authors: Salah Raed Omar , Alzboon Habis , AlTalhoni Mansour Hamed
Published: February 2020

This study aimed to identify the degree of practice of the teachers in Ma'an Governorate for the skills of building achievement tests. In order to achieve the objectives of the study, a questionnaire was developed consisting of (36) items divided into two domains. After confirming the psychometric properties of the questionnaire, it was applied on the study sample which consisted of (186) male and female teachers at Ma'an Governorate. The study sample was randomly selected.The results of the study indicated that the degree of the practice of the teachers of Ma'an Governorate for the skills of building the achievement tests was average. They also indicated that there were no statistically significant differences according to the gender variable, and there were statistically significance differences attributed to the variable of specialization in favor of the scientific specialties over the humanities. Furthermore, there were statistically significant differences attributed to the experience and qualifications variables in favor of the master’s degree holders compared to those of bachelor’s degrees. It was also found that the most important needs to build the achievement tests for the teachers of Ma'an Governorate were to provide special evidence for the building of the achievement tests, followed by conducting training sessions specialized in the building of tests for the preparation of new teachers.
A Multicultural Citizenship Education Program Through a Virtual Learning Environment Platform: A Greek Study Under the EU ISOTIS Project
Authors: Vasileiadis Konstantinos N. , Kompiadou Evdoxia D. , Tsioumis Konstantinos A. , Petrogiannis Konstantinos
Published: February 2020

The article presents the activities taken place to design and implement activities that meet the criteria, aims and goals of ISOTIS project that aims to contribute to effective policy and practice development at different system levels in order to effectively combat early arising and persisting educational inequalities. We focus on the procedures and theoretical framework that the Greek team, as partner of ISOTIS project adopted to support diverse families both linguistically and culturally, to create effective and inclusive curricula and moreover to develop educational policy to combat educational inequalities. In this paper we introduce the criteria for selecting the sites according to the demographic and their pedagogical characteristics, the teacher’s experience, the children’s needs and the main issues, challenges and arguments for the co-design phase and the main principles and shared ideas according to ISOTIS criteria. This paper highlights positive family/parent-teacher interactions through ICT technologies, fostering to improve and promote inclusiveness and belongingness. Our theoretical framework lays in critical multicultural citizenship education and democratic governance in schools.
Measuring Intellectual Capital in Schools in the Developing Country of Pakistan
Authors: Niqab Muhammad , Hanson Janet , Bangert Arthur , Kannan Sathiamoorthy , Sharma Sailesh , Ghaffar Abdul , Mubarik Muhammad Shujaat
Published: February 2020

This study used a quantitative, empirical, survey-research design and collected self-report data from faculty (n = 408) in secondary-level schools (n = 34) in Pakistan to test the reliability and construct validity of a proposed three-factor model of intellectual capital (IC). Results of the exploratory and confirmatory factor analyses showed the three-factor model was reliable to quantify the construct of IC in Pakistan secondary-level schools. Factors included social relations, teacher experience and education, and teacher training and skills. Structural capital was tested indirectly. Statistically significant differences existed between school types for the IC mean scores, revealing an influence of structural capital on IC. Gender was included as a control variable in the analyses demonstrating no significant influence on the dependent variable, IC. School administrators and policy makers can use the results of this study to inform decision making and to support self-developing processes in schools in the effort to reduce the divide in educational outcomes between developed and developing countries.
El feminismo de la segunda ola en México y su relación con otros movimientos de mujeres
Authors: Ortiz San Juan Yearim A.
Published: February 2020

The neo-feminist women, when articulating the private and public spheres, evidenced the sexual violence that was exercised on women. In order to study this movement, it is convenient to make a brief history of the second wave of feminism in Mexico, particularly that of Mexico City, and to explain how its postulates became part of the political agenda.
Conceptos clave en los estudios sobre religión a propósito de la publicación de Homo religiosus : sociología y antropología de las religiones
Authors: Martínez Villarroya Javier
Published: February 2020

La reciente publicación del libro Homo religiosus. Sociología y antropología de las religiones, sirve de excusa para recorrer las ideas fundacionales de algunas de las principales escuelas de estudios sobre religión. Hoy en día, el interesado en estudiar el fenómeno de lo religioso debe ser consciente del origen y significado de conceptos tales como "mana", "numinoso", "hecho social total", "estructura", "inconsciente colectivo", "arquetipo", "eterno retorno", entre otros, y este libro le será de gran ayuda
Evaluating an English Course for Master Students in China: A Case of Business English for Accounting Program
Authors: Wenjie Shi
Published: February 2020

This study aims to evaluate a business English course for students registered in Master of Professional Accounting or Accountancy (hereafter MPAcc) based on needs analysis of the degree candidates. An online questionnaire, semi-structured interview and classroom observation were used to gain data on the candidates' perception and motivation of learning Business English, learning needs concerning language skills, course contents and course delivery. The results show that the candidates placed importance on learning the language for practical use in business-related domain in general, and for accounting business in particular, and the current in-house business English syllabus has better satisfied the learners need by adopting up-to-date business literature, engaging the learners in discussion. The findings also reveal some issues in designing and teaching courses of English for Specific Purposes (hereafter ESP), including inadequate involvement of accounting specific knowledge in the course contents, lower-than-expected learning outcomes caused by super-large class sizes and limited course availability. Finally, recommendations are given based on the findings as to revise course syllabus and update course arrangement by taking account of the adult language learners' needs pertaining to MPAcc program.
A randomized, controlled trial of transcutaneous tibial nerve stimulation to treat overactive bladder and neurogenic bladder patients
Authors: Welk Blayne , McKibbon Mary
Published: February 2020

Introduction: We aimed to determine if transcutaneous tibial nerve stimulation (TTNS) is effective at treating overactive bladder (OAB) symptoms among neurogenic and non-neurogenic patients.

Methods: We conducted a randomized, double-blind, sham-controlled study. Adult patients were recruited from one of two groups: 1) women with OAB; and 2) patients with neurogenic disease and bladder symptoms. The intervention was stimulation of the posterior tibial nerve, for 30 minutes, three times per week for 12 weeks at home using transcutaneous patch electrodes. The primary outcome was improvement of the patient perception of bladder condition (PPBC). We used ANCOVA (with adjustment for baseline values) and followed the intention-to-treat principle; we reported marginal means (MM) and a p<0.05 was considered significant.

Results: We recruited 50 patients (OAB n=20, neurogenic bladder n=30); 24 were allocated to the sham group and 26 to the active TTNS group. Baseline characteristics in both groups were similar. At the end of the study, there was no significant difference in the PPBC between sham or active groups: 13% (3/24) of sham patients and 15% (4/26) of active TTNS patients were responders (p=0.77), and the marginal mean of the end-of-study PPBC score was 3.3 (95% confidence interval [CI] 2.8–3.7) vs. 2.9 (95% CI 2.5–3.4), respectively (p=0.30). Similarly, there were no significant differences in secondary outcomes (24-hour pad weight, voiding diary parameters, or condition-specific patient-reported outcomes). The results were similar within the OAB and neurogenic bladder subgroups.

Conclusions: TTNS does not appear to be effective for treating urinary symptoms of people with OAB or neurogenic bladder dysfunction.
Psychosociale aspecten van crisismanagement: taken en uitdagingen voor bestuur en beleid
Authors: Dückers Michel , van Hoof Wera , Holsappel Jorien
Published: February 2020

Psychosocial aspects of crisis management: Tasks and challenges for public leadership and policy

Crises and disasters can seriously affect the health, well-being and functioning of the people involved. From a governance perspective, it is important that public leaders and crisis managers are aware of what the psychosocial dimension of crisis management entails. The objective of the current contribution is to analyse dilemmas and challenges described in evaluations of crises that occurred in the Netherlands between 2012 and 2016. Thirty-six evaluations were analysed against the background of a theoretical framework combining crisis leadership tasks and psychosocial support principles along the crisis life cycle. Public leaders and crisis managers had to deal with classical crisis problems concerning coordination, collaboration and communication. Other recurring themes were linked to social media, and the tension between tasks such as meaning making (social recognition), account giving and learning. Moreover, the analysis illustrates how difficult it is to gain insight into the needs, problems and vulnerabilities of the individuals and groups affected.
‘Gelukkig is geen ramp ontstaan’
Authors: Blommers Michael
Published: February 2020

‘Fortunately no disaster has occurred’ – meeting the needs of victims after big fires

Based on a retrospective analysis of six large scale and fatal fires in the Netherlands, an improvement in terms of meeting the needs of victims can be seen. A comparison of the legal settlement of these fires shows mayor differences in the fulfilling of different aspects of social justice that are identified in social psychology. Two victim needs commonly associated with retributive justice – financial compensation and a thorough, neutral investigation into the causes of the disaster – were fulfilled to a higher degree after the most recent fires than after those that occurred decades ago. The legal settlement after the New Year’s fire in Volendam (2001) appears – at least on paper – to have been more just from the victim’s point of view than the ones after the other incidents. Empirical research into the experienced social justice after the New Year’s fire can be valuable to assess the factors that can lead to a just settlement after disasters.
Kazakhstani immigration policy impact for ethno-demographic structural changes
Authors: Amangul Shugatai
Published: February 2020

After the collapse of the Soviet Union, the Kazakhstan government implemented ethnic-based immigration policies which call for ethnic Kazakhs from abroad return to their historical homeland. In 1991, Kazakhstan started a repatriation process of calling back its ethnic Kazakh to belong to the new nation, and to their new found ethnic identity. The immigration policies has including the “repatriation process of ethnics”, have helped significantly as Kazakhs tries to reconcile past wrongs, increase internal stability and conserve national identity. Because of the Soviet era much of Kazakh language and traditional cultures was sufficiently reduced in the public sphere, and the ethnic composition in this country was dominated by non-titular ethnics Thus, that ethnic immigration policy focused on change ethno-demographic structure of the Kazakhstan and increasing the total population size. This article focused to analyze the results of the ethnic immigration policy of Kazakhstan, how it has changed the immigration policy over the last 30 years.

Казахстан улсын угсаатны шилжилт хөдөлгөөний бодлого, түүний үр дүн

Хураангуй: 1991 онд Зөвлөлт Холбоот Улс (ЗХУ) задарч, Бүгд Найрамдах Казахстан Улс (БНКазУ) байгуулагдсаны дараа тус улсад хүн амын “олон улсын шилжилт хөдөлгөөн”-ий урсгал эрчимтэй явагдаж эхэлсэн билээ. Шинээр тусгаар тогтносон БНКазУ хүн амын тогтвортой өсөлтийг дэмжих, нийт хүн амд казах угсаатны эзлэх хэмжээг нэмэгдүүлэх замаар угсаатны бүтцээ өөрчлөх, нийгэм эдийн засгийн хөгжилтэй уялдуулан хүн амын амьжиргааны түвшинг дээшлүүлэх зэрэг зорилтуудыг дэвшүүлсэн. Энэ хүрээнд дэлхийн өнцөг булан бүрээс казах угсаатнуудыг өөрсдийн “түүхэн эх нутаг” (historical homeland) болох БНКазУ-д шилжин ирж суурьших уриа дуудлага болгож, хүн амын шилжилт хөдөлгөөний тусгай бодлогыг хэрэгжүүлсэн. Ингэснээр БНКазУ-ыг чиглэсэн казах үндэстний хил дамнасан шилжилт хөдөлгөөн бүс нутгийн ба дэлхийн хэмжээнд эрчимтэй өрнөж, өнөөдрийг хүртэл тасралтгүй үргэлжилж байна. Энэхүү өгүүлэлд БНКазУ-ын Засгийн газраас нийт хүн амд эзлэх казах үндэстний тоог нэмэгдүүлэх, угсаатны бүтцийг өөрчлөхийн тулд 1991 оноос хойш 30 орчим жилийн хугацаанд хэрэгжүүлж буй шилжилт хөдөлгөөний (цагаачлал) бодлогын хэрэгжилт, түүний үр дүнд задлан шинжилгээ хийхийг зорилоо.

Түлхүүр үг: Бүгд Найрамдах Казахстан Улс, хүн ам зүйн бодлого, угсаатны бүтцийн өөрчлөлт, диаспора, казах үндэстний шилжилт хөдөлгөөн
Histological evaluation of soft palate tissues in patients with sleep disordered breathing
Authors: Panek Justyna , Reszeć Joanna , Rogowski Marek , Olszewska Ewa
Published: February 2020

Introduction Sleep is a physiological state essential for proper functioning of the body. One of the reasons for sleep disorders is obstructive sleep apnea syndrome (OSAS). Aim: The aim of this research is histological evaluation of the mucous membrane of the soft palate in patients affected by various forms of OSAS. Material and method: The studied group consisted of patients with sleep-related breathing disorder in the form of primary snoring or OSAS. People with chronic tonsillitis, without a history of sleep-related breathing disorders, were included in the comparative group. Fragments of the mucous membrane of the uvula (study group) and the glossopalatine arch (comparative group) were taken for histological examination during surgery. Using histological, histochemical and immunohistochemical methods, we assessed the presence and severity of inflammation (CD3, CD20, CD68), the structure of nerve fibers (S-100) and the size of blood vessels (CD34) in the examined tissue. Results: Patients with OSAS developed a local inflammatory process in the oropharyngeal tissues (stronger expression of CD3, CD20, CD68 in people with OSAS). The exacerbation of the immunohistochemical reaction with CD3 correlated with the phase of OSAS. We found a higher degree of fibrosis and a higher expression of CD34 and S-100 receptors in subjects with OSAS compared to snoring patients and patients from the comparative group. Discussion: Due to chronic tissue vibration, snoring most likely leads to damage to the nerve fibers in the soft palate, which can intensify episodes of shallow breathing during sleep and increase the occurrences of apnea.
The current state of retinopathy of prematurity in India, Kenya, Mexico, Nigeria, Philippines, Romania, Thailand, and Venezuela
Authors: Bowe, BS Theodore , Nyamai, MD Lily , Ademola-Popoola, MD Dupe , Amphornphruet, MD Atchara , Anzures, MD Rachelle , Cernichiaro-Espinosa, MD Linda A. , Duke, MD Roseline , Duran, MD Fahir , Martinez-Castellanos, MD Maria Ana , Multani, DNB Prabhujot Kaur , Nitulescu, MD Cristina E. , Padhi, MS Tapas Ranjan , Tipsuriyaporn, MD Boontip , Chan, MD, MSc R.V. Paul , Yonekawa, MD Yoshihiro
Published: February 2020

Retinopathy of prematurity (ROP) is one of the leading causes of preventable blindness in children worldwide. Middle-income nations are currently experiencing epidemic levels of ROP, because greater access to neonatal intensive care units has improved survival rates of premature infants, but without sophisticated oxygen regulation. The epidemiology, screening infrastructure, treatment options, and challenges that these countries face are often tied to unique local socioeconomic, cultural, geopolitical, and medical factors. We present an overview and narratives of the current state of ROP in eight countries that are or soon will be experiencing ROP epidemics—India, Kenya, Mexico, Nigeria, Phillipines, Romania, Thailand, and Venezuela—with a view to fostering both an understanding of the differences in the ROP landscape in various settings and an interest in the further development of ROP screening and treatment services tailored to local requirements.
BASE NACIONAL COMUM CURRICULAR:IMPLEMENTAÇÃO DA PROPOSTA CURRICULAR PARA A EDUCAÇÃO INFANTIL NO MUNICÍPIO DE NOVA IGUAÇU
Authors: Costa Rejane Peres Neto , Nascimento Anelise Monteiro do , Neves Luana Ramos
Published: February 2020

This paper has as object the curriculum (re)formulation policy based on the Brazilian federal law nº 12.796/2013 curricular standards, known as Base Nacional Comum Curricular, and implemented by the Brazilian Ministry of Education (Ministério da Educação –MEC). The present article specifically addresses the early childhood education propositions in the mentioned policy. In order to analyze the development of such policy at the municipal level, as well as its arrangements, adjustments, tensions and results,we observed the work developed by the Educational Department of Nova Iguaçu city during the years of 2018 and 2019, department known as Secretaria Municipal de Educação do Município de Nova Iguaçu. As a methodological theoretical framework, Michael Apple’s Relational Analysis helped to understand the curricula formulation standards as one proposal among other educational policies. In a short period of time, alongside a school community’s low participation scenario and yet without the final document’s publication/circulation, the aforementioned city of Nova Iguaçu met its goals of curriculum reformulation.
Labour Trafficking and Exploitation in Rural Andalusia
Authors: Correa da Silva Waldimeiry , Cingolani Carla
Published: February 2020

This chapter presents the preliminary results of a research project, called “Research on the Vulnerability of Human Rights in Andalusian Rural Areas: Migration, Labour Treatment, and Other Forms of Exploitation for the Strengthening of Andalusian Development Agents”. In the mentioned research, we analyse the trafficking in persons for the purpose of labour exploitation (labour trafficking) and labour exploitation in the rural context of Andalusia. For this, the research focuses on three (3) provinces of Andalusia in which the fieldwork is carried out in rural areas of the provinces of Almeria, Seville and Huelva. For that purpose, this study will be structured in four sections: first, the realisation of a conceptual introduction on “labour trafficking”, its connection with contemporary forms of slavery and exposure of the factors that favour the development of this phenomenon in the Andalusian context; second, presentation of the partial data that allow us to make a localised diagnosis through the contextual approach of labour exploitation and labour trafficking in Andalusia; third, analysis of the results; and fourth, conclusions on the confrontation with the labour treatment in Spain.
Potential of Biocatalysis in Pharmaceuticals
Authors: Soy Snehi , Prabha Riddhi , Kumar Nigam Vinod
Published: February 2020

Biocatalysis has been continuously evolving as an essential tool which is playing a significant role in the industrial synthesis of chemicals, active pharmaceuticals, pharmaceutical intermediates, etc. where the high-yielding chemo-, regio-, and enantioselective reactions are needed. Despite its vital importance, industrial biocatalysis is facing certain limitations such as operational stability, economic viability, efficient recovery, and reusability. The limitations mentioned can be overcome by the isolation of specific enzyme producers from extreme environment by protein engineering, bioinformatics, and recombinant DNA technologies. Recently, chemoenzymatic pathway and biological cascade reactions have also been developed and designed to perform the synthesis of pharmaceuticals. In this chapter, we compile the broad applications of biocatalysts in the synthesis of pharmaceuticals.
Sudden Cardiac Death in Young Athletes
Authors: Makarov Leonid
Published: February 2020

Sudden death (SD) is the most dangerous and irreversible outcome of diseases in clinical as well as in sports medicine. Between 1980 and 2011, the Sudden Death in Young Athletes Registry in the USA, which was developed based on mass media information, recorded 2406 cases of sudden death, which were observed in 29 diverse sports. In the USA 80% of all SD occurred in high school/middle school or collegiate student athletes, and 20% were engaged in organized youth, postgraduate. Statistical data vary greatly in different countries: SCD incidence rate in the USA is 7.47 and 1.33 per 1,000,000 exercising male and female school-age athletes, respectively, whereas in Italy, the rate is 2.6 cases in men and 1.1 in women per 100,000 individuals per year who are involved in active competitive sports. The European Heart Rhythm Association (EHRA) position paper concluded that as an overall estimate, 1–2 out of 100,000 athletes between of age of 12 and 35 years old die suddenly each year. It was shown that the risk of SCD is significantly higher in athletes than in nonathletes with the same heart condition in the general population, by more than five times for ARVC, 2.6 times for coronary artery disease, 1.5 times for myocarditis, and more than 2 times for cardiac conduction system diseases.
Recent Advances in the Effects of Various Surgical Methods on Tear Film after Pterygium Surgery
Authors: Wang Juan
Published: February 2020

Pterygium is a common ocular disorder with a high prevalence. Surgical resection is the main method of treating pterygium. Recurrence rate of traditional surgical methods such as simple excision of pterygium is high. In recent years, amniotic membrane transplantation, autologous limbal stem cell transplantation, application of mitomycin (MMC) and some other methods become commonly used. Autologous limbal stem cell transplantation is being most widely used. Pterygium has a close relationship with dry eye, and dry eye is one of the important reasons for its recurrence. Different surgical methods have different effects on postoperative tear film. This review will summarize the recent points.
Prospects of 5G Satellite Networks Development
Authors: Tikhvinskiy Valery , Koval Victor
Published: February 2020

In the future, 5G networks will represent the global telecommunication infrastructure of the digital economy, which should cover the whole world including inaccessible areas not covered by 5G terrestrial networks. Given this, the satellite segment of 5G networks becomes one of the pressing issues of development and standardization at the second stage of 5G networks development in the period 2020–2025. The requirements for 5G satellite network will be determined primarily by combination of key services supported by 5G networks, which are combined by three basic business models of 5G terrestrial networks: enhanced Mobile Broadband Access (eMBB), Massive Internet of Things connections (mIoT), and Ultra-reliable low-latency communication (uRLLC). 3GPP as leading international standards body has identified several use cases and scenarios of 5G satellite networks development. 5G satellite networks are understood to mean networks in which the NG-RAN radio access network is constructed using a satellite network technology. The chapter has discussed the spectral and technological aspects of 5G satellite network developments, issues of architecture and role of delays on quality of services of 5G satellite segment, and possibility of constructing a 5G satellite segment based on distributed and centralized gNB base stations. The issues of satellite payload utilization have considered for bent-pipe and on-board processing technologies in 5G satellite segment.
Collaborative Production Model of Educational Resources for Human-Computer Interaction Community in Latino America
Authors: Muñoz-Arteaga Jaime
Published: February 2020

Today, human-computer interaction (HCI) shows great activity, dynamism, and academic presence throughout the world, having special relevance in the Latin American region. The region is not only vast for its geographical space but also diverse and multicultural, where researchers and academics from this area or community have proposed and made known the benefits of the HCI that they can bring to today’s society. However, some problems arise and need to be addressed in the HCI area in the Latin American region, such as the lack of training strategies and the availability of content and educational resources in Spanish. In order to mitigate this problem, the current work proposes a collaborative production model of educative resources for human-computer interaction developed in Latin America. The model preconizes a series of strategies and technological services to support the collaborative production and access of HCI educative resources such as videos, slides, handouts, textbooks, user experience analysis, and usability tests. The proposed model is tested throughout two real case studies conducted by teachers and researchers from different Latin American universities in order to produce and use the HCI educative resources for under- and postgraduate courses.
Don’t Objectify Me!: Sexual Self-Monitoring, Coping, and Psychological Maladjustment
Authors: Baggett Catherine , Nagoshi Craig , Nagoshi Julie
Published: February 2020

Undergraduate college students (283 females, 127 males) completed surveys aimed at measuring positive sexual awareness vs. sexual self-monitoring, coping styles, and psychopathological symptoms. Positive sexual awareness significantly positively correlated with adaptive coping styles but did not otherwise correlate with psychopathological symptoms. Sexual self-monitoring was significantly positively correlated with somatization, depression-anxiety, and avoidant coping in women but not men. Bootstrapped mediation analyses indicated that the relationships between sexual self-monitoring and somatization, depression-anxiety, and eating disorder symptoms were significantly mediated by avoidant coping in women but not in men. These results were explained in terms of Objectification Theory, suggesting that women who experience sexual objectification are more likely to engage in avoidant coping, thus increasing their risk of developing psychopathology. Findings are discussed in terms of broader issues of the disempowering effects of objectification.
Pathology of Treated Pancreatic Ductal Adenocarcinoma and Its Clinical Implications
Authors: Nagaria Teddy Sutardji , Wang Hua , Chatterjee Deyali , Wang Huamin
Published: February 2020

Context.—

Preoperative neoadjuvant therapy has been increasingly used to treat patients with potentially resectable pancreatic ductal adenocarcinoma (PDAC). Neoadjuvant therapy often induces extensive fibrosis in tumor, adjacent pancreatic parenchyma, and peripancreatic tissue. Histopathologic evaluations and histologic tumor response grading (HTRG) of posttherapy pancreatectomy specimens are very difficult and challenging. Studies on prognostic significance of posttherapy pathologic staging, optimal system for HTRG, and other pathologic parameters in treated PDAC patients are limited.

Objective.—

This review is to provide a timely update of the prognostic values of posttherapy pathologic staging, HTRG, and other pathologic parameters in PDAC patients who received neoadjuvant therapy and pancreas resection.

Data Sources.—

Systemic review of major studies on pathologic evaluation and its clinicopathologic implications in treated PDAC patients.

Conclusions.—

Systemic pathologic examination, histologic tumor regression grading, pathologic evaluation of the margins, tumor involvement of superior mesenteric vein/portal vein, accurate pathologic staging, and reporting of posttherapy pancreatectomy specimens provide highly valuable prognostic information for postoperative patient care. Our findings suggest for the first time that tumor size of 1.0 cm, instead of 2.0 cm, is a better cutoff for ypT2 in PDAC patients. The newly proposed 3-tier MD Anderson HTRG system not only has proved to be an independent prognostic marker for PDAC patients who received neoadjuvant therapy and pancreatectomy, but also improves interobserver agreement among pathologists in evaluation of tumor response. This grading system should be considered in future editions of the College of American Pathologists protocol for PDAC.
Grants and Acquisitions
Authors: Galloway Ann-Christe
Published: February 2020

The University of Pennsylvania Libraries has received a series of gifts from Arnold and Deanne Kaplan, including the world’s first endowed position in Judaica digital humanities, totaling $12 million. The Kaplans’ contributions also comprise an in-kind gift of collections of Americana and Early American Judaica, research fellowships, and an endowment for continuing acquisitions.
Familias multiproblemáticas y el programa de apoyo a familias en Soria
Authors: Pascual Lavilla Senador
Published: February 2020

El siguiente artículo es un estudio de las familias multiproblemáticas a través de una investigación con familias usuarias del Programa de Apoyo a Familias. En él se analizan una serie de características que hemos considerado importantes para entender este tipo de familias y la causa de muchos de los problemas a los que se enfrentan. Se prende con esto, llegar a entenderlas mejor y conseguir resultados más positivos en intervenciones sociales que se realicen con ellas.The following article is a study of multi-problem families through an investigation with families which are users of the Family Support Program. The article analyzes a series of characteristics which we have considered important in order to understand this type of families as well as the cause of many of the problems they face.The aim of this article is to understand them better and reach more positive results in social interventions that are carried out with them.
La educación especial en Ciudad Juárez: reflexión y acción
Authors: Santos Fabelo María del Carmen , Pérez Díaz Addiel
Published: February 2020

El artículo está basado en investigaciones recientes que permiten constatar cómo se encuentra Ciudad Juárez respecto a la demanda de los cambios en la Educación Especial. La información se obtuvo utilizando una metodología mixta que permitió obtener datos para reflexionar y accionar al respecto. De una población conformada por 20,412 habitantes de las colonias marginadas, se tomó una muestra aleatoria simple de 8,301 y resultaron con necesidades educativas especiales y/o discapacidad el 19.3%. A partir de este estudio se han realizado diversas acciones y reflexiones para modificar situaciones negativas, abordándose la apertura del primer Diplomado en Educación Especial en el 2006 y de la Maestría en Educación Especial en el 2007.The article is based on recent research that shows how Ciudad Juárez is in relation to the demand for changes in Special Education. The information was obtained using a mixed methodology that allowed obtaining data to reflect and act on it. From a population consisting of 20,412 inhabitants of marginalized colonies, a simple random sample of 8,301 was taken and 19.3% were found with special educational needs and / or disability. From this study, various actions and reflections have been carried out to modify negative situations, addressing the opening of the first Diploma in Special Education in 2006 and the Master in Special Education in 2007.
Refining the Factor Structure of the All Aspects of Health Literacy Scale
Authors: Barsell D. Jeremy , Everhart Robin S. , Perrin Paul B.
Published: February 2020

Objective: Although the All Aspects of Health Literacy Scale (AAHLS) is a commonly used measure of health literacy, the psychometric evaluation approach employed in its original validation is questionable. In this study, we evaluated the psychometric properties and factor structure
of the AAHLS using widely-accepted analytic methods. Methods: We collected data from 393 students from a Mid-Atlantic university. Participants completed the AAHLS in an online format. We conducted an exploratory factor analysis (EFA) to determine whether a different factor/subscale
structure emerged in this sample than in the original validation sample. We ran follow-up confirmatory factor analyses (CFAs). Results: The EFA suggested an 11-item, 4-factor model. The CFA of the 4-factor model had adequate model fit but evidenced several low item loadings, suggesting
that several items did not perform well. We tested a modified 8-item, 3-factor model that had good fit and high item loadings. Compared to the original factor structure, the functional health literacy subscale was removed. Conclusions: The newly proposed 3-factor/subscale model with
8 items captures communicative health literacy and 2 separate aspects of critical health literacy. Further replication in other diverse samples is warranted to investigate the psychometric properties of the AAHLS, although we recommend use of the revised version over the original.
Medication Adherence Changes in Blacks with Diabetes: A Mixed Methods Study
Authors: Rao Deepika , Maurer Martha , Meyer Jodi , Zhang Jiaying , Shiyanbola Olayinka O.
Published: February 2020

Objectives: In this study, we conducted a longitudinal evaluation of changes in medication adherence and the role of psychosocial and interpersonal factors in these changes among Blacks with type 2 diabetes mellitus (T2DM), and determined barriers and facilitators of T2DM medication
adherence. Methods: We used an explanatory sequential mixed methods design for a sample of 287 black adult patients with T2DM in Wisconsin. Two surveys quantitatively evaluated changes in medication adherence, psychosocial factors, and interpersonal factors over time. We conducted 10
semi-structured qualitative interviews to explore participants' perceptions of these changes. Data integration of the quantitative and qualitative findings elucidated barriers and facilitators of medication adherence. Results: Increased adherence was significantly correlated with less
concerns about medicines (r = -0.31), higher self-efficacy (r = 0.47), lesser depressive symptoms (r = -0.26), and lesser negative illness perceptions (r = -0.26) at both baseline and follow-up. Patient perceptions of adherence changes included adherence motivators, social support, and complex
medication regimens. Integration showed that barriers and facilitators both existed in individuals who had an increase or a decrease in adherence over time. Conclusions: Specific beliefs of Blacks towards T2DM medications must be addressed to improve their adherence. Interventions must
be tailored using interpersonal factors.
Sex and Racial/Ethnic Differences in Suicidal Consideration and Suicide Attempts among US College Students, 2011-2015
Authors: Sa Jaesin , Choe Ches Siyoung , Cho Ches Beom-Young , Chaput Jean-Philippe , Lee Jounghee , Hwang Sungjae
Published: February 2020

Objectives: In this study, we examined sex and racial/ethnic differences in the prevalence and predictors of suicide consideration and attempts among US college students. Methods: We used multivariable logistic regression to investigate suicide consideration and attempts
by sex and race/ethnicity among students (N = 319,342) who completed the American College Health Association-National College Health Assessment from fall 2011 to spring 2015. Results: Overall, the prevalence of suicide consideration and attempts was higher in spring 2015 than fall 2011
(p < .05). Men had higher odds of suicide consideration and attempts than women (p < .001). Blacks, Hispanics, and Asians had higher odds of suicide consideration and attempts compared with Whites (p < .001). Weight-related problems (unhealthy weight, body weight overestimation, and
lack of physical activity), sleep problems (insufficient sleep and sleep difficulties), and lower levels of academic performance were associated with both suicide consideration and attempts (p < .05). Conclusions: Our findings indicate a need for sex- and race/ethnicity-specific
suicide prevention strategies for college students, specifically men and racial/ethnic minority groups. Furthermore, appropriate weight and sleep management could be considered to help prevent suicide among US college students.
Devenir « noir » sur les routes migratoires
Authors: El Miri Mustapha
Published: February 2020

Les « Subsahariens » qui ont franchi les frontières géographiques pour arriver au Maroc avant d’entreprendre un passage vers l’Europe découvrent qu’ils sont porteurs d’une frontière tout aussi difficile à franchir. Ces personnes deviennent « noires » sur les routes migratoires et font l’expérience du racisme. Elles essaient, tant bien que mal, de s’adapter à ce qui est un obstacle supplémentaire, et non des moindres, sur leur parcours : elles se découvrent les représentantes d’une altérité radicale inscrite dans leur corps. Leur expérience nous montre que le racisme est multiforme. Il convoque les idéologies esclavagistes, coloniales, suprémacistes et les articule avec une image contemporaine de l’Africain noir débarquant sur les plages espagnoles, italiennes, grecques, en provenance des côtes libyennes, marocaines, ou tunisiennes. À l’intersection de la figure coloniale et esclavagiste du Noir et des migrants africains actuels, les « Subsahariens » subissent une double altérisation : raciale et sociale.
Taire la race pour produire une société incolore ?
Authors: Lavanchy Anne
Published: February 2020

Cet article analyse les rapports sociaux de race à partir des pratiques administratives destinées à lutter contre les « abus » dans des contextes de « mixité ». Il montre que les pratiques administratives jouent un rôle décisif dans le contrôle des frontières symboliques de la nation, tout comme des modalités de sa reproduction, organisée autour de la blanchité. Partant de l’analogie entre les expressions émiques de mixité et de binationalité, l’auteure met en évidence qu’au-delà de la mutité de la race, les références à des lectures des corps — couleur de peau — comme à d’autres attributs identitaires — nationalité, genre et sexualité — jouent un rôle déterminant mais cependant tu pour traiter des demandes, en lien avec les notions émiques de mariage mixte, mariage de complaisance, mariage gris. Les couples s’écartant de la norme implicite d’homogamie raciale sont soumis à des dispositifs de discipline et de surveillance visant à les rappeler à l’ordre. Ces mécanismes renforcent l’ordre racial et disciplinent tant les personnes blanches que non blanches, avec des effets différents en fonction du genre et de la sexualité.
Représentations de l’intimité hétérosexuelle et transformations sociales : vers une sémantique amoureuse intégrée1
Authors: Piazzesi Chiara , Blais Martin , Lavigne Julie , Lavoie-Mongrain Catherine , Renière Roxane
Published: February 2020

Il existe trois positions principales dans la littérature sociologique occidentale sur les transformations de l’intimité et des imaginaires amoureux contemporains : la thèse de l’individualisation comme émancipation de la tradition, la thèse de la détraditionnalisation comme déliaison et la thèse de la coexistence entre tradition et modernisation dans les discours et les pratiques intimes. À partir d’une étude de cas sur la télésérie québécoise La Galère (2007-2013), cet article propose une quatrième approche pour aborder ces transformations qui permet de dépasser les limites théoriques et empiriques des trois positions mentionnées. Cette approche développe le concept de « sémantique intégrée » pour décrire en détail les éléments des sémantiques en circulation dans les produits culturels occidentaux, ainsi que les modalités de la coexistence entre imaginaires traditionnels et imaginaires novateurs. De plus, cette approche offre des outils conceptuels pour formuler des hypothèses sur la relation entre les évolutions sémantiques et les transformations sociales contemporaines dans la sphère intime.
Opposite changes in APP processing and human Aβ levels in rats carrying either a protective or a pathogenic APP mutation
Authors: Tambini Marc D , Norris Kelly A , D'Adamio Luciano
Published: February 2020

Cleavage of APP by BACE1/β-secretase initiates the amyloidogenic cascade leading to Amyloid-β (Aβ) production. α-Secretase initiates the non-amyloidogenic pathway preventing Aβ production. Several APP mutations cause familial Alzheimer’s disease (AD), while the Icelandic APP mutation near the BACE1-cleavage site protects from sporadic dementia, emphasizing APP’s role in dementia pathogenesis. To study APP protective/pathogenic mechanisms, we generated knock-in rats carrying either the protective (Appp) or the pathogenic Swedish mutation (Apps), also located near the BACE1-cleavage site. α-Cleavage is favored over β-processing in Appp rats. Consequently, non-amyloidogenic and amyloidogenic APP metabolites are increased and decreased, respectively. The reverse APP processing shift occurs in Apps rats. These opposite effects on APP β/α-processing suggest that protection from and pathogenesis of dementia depend upon combinatorial and opposite alterations in APP metabolism rather than simply on Aβ levels. The Icelandic mutation also protects from aging-dependent cognitive decline, suggesting that similar mechanisms underlie physiological cognitive aging.