bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluate the safety of a novel photohydrolysis technology used to clean and disinfect indoor air: A murine study
Authors: Selitrennikoff Claude P. , Sylvia Charles , Sanchez Maria , Lawrence Patricia , Trosch Kimberly , Carenza Amy , Meschter Carol
Published: October 2024

There is a pressing need to develop new technologies that continuously eliminates harmful pollutants and pathogens in occupied indoor spaces without compromising safety. This study was undertaken to test the safety of a novel air cleaning and disinfection technology called Advanced Photohydrolysis. Advanced Photohydrolysis generates a complex mixture of ions and molecules that are released into the air and has been shown to reduce airborne and surface pathogens. Mice (6–8-week-old) were exposed to therapeutic levels of Advanced Photohydrolysis for 90-days. During the study, the Advanced-Photohydrolysis-exposed and control mice were monitored for food consumption, body weight gain, and any overt adverse effects. In addition, at the conclusion of the study, the blood chemistry and hematology values of both groups were determined. Finally, the tissues of the conduction and respiratory portions of the airways of mice from both groups were examined for any pathological changes. The mice of both groups were found to be normal and healthy throughout the 90-day study; there were no differences in the behavior, food consumption and weight gain. Analysis of clinical chemistry values found no differences in hepatocellular function or other markers of cellular and organ function, and clinical hematology values were also unremarkable. Finally, and importantly, histopathology of the upper and lower airway tissues showed no deleterious effects. These results are the first to demonstrate directly the safety of Advanced Photohydrolysis on live mammals and encourage additional studies.
Health impact of the COVID-19 in Spanish non-healthcare workers by gender: Use of sickness absence for surveillance
Authors: Culqui L. Dante R. , Gherasím Alín Manuel , Escalona López Sofía , Oliva Domínguez Jesús , García Gómez Montserrat
Published: October 2024

Introduction

At the beginning of the pandemic, the identification of transmission chains was biased towards more closely monitored sectors, such as healthcare and sociosanitary centers.

Objective

The objective of our research is to describe the impact of the pandemic on the Spanish non-healthcare workers measured through health-related workplace absences.

Methods

A descriptive study of the cases of COVID-19-related temporary disability (TD) between February 15th and September 17th, 2020, was carried out. TD quarantine/infection ratios were calculated for every economic sector of activity. Rates of COVID-19 TDs per 100,000 affiliated workers were obtained, by gender, age, economic activity of the company or occupation of the worker.

Results

A total of 1,126,755 TDs were recorded, 45.4% in women. The overall TD rates were 5,465 quarantines and 1,878 illnesses per 100,000 women, and 4,883 quarantines and 1,690 illnesses per 100,000 men. The highest incidence rates of TD due to illness were observed in younger age groups, under 30. The median TD quarantine/infection ratio was 2.6 (Interquartile range [IQR] 1.5–3.9), and Postal and Courier activities had the highest value: 4.7 quarantines per case (IQR: 3.75–6.12). The TD rates were higher in female workers in most sectors of activity and occupations compared to men in the same sectors and with the same occupations. The results show the uneven impact of COVID-19 by occupation, with a higher rates in less qualified occupations (unskilled workers and laborers) versus the first categories of the table (directors, managers, technicians, and professionals).

Conclusions

The results confirmed the high impact of COVID-19 on Spanish non-healthcare workers and it’s inequalities. They also confirmed the potential use of TDs as an alternative source for epidemiological, public health surveillance and early warning of new emerging infections.
Pharmacological treatment of postoperative recurrence of Crohn’s disease: Protocol for systematic review and network meta-analysis
Authors: Jiang Tianxiang , Cai Zhaolun , Liu Chunjuan , Zhang Bo
Published: October 2024

Background

Crohn’s disease (CD) is a chronic inflammatory condition primarily affecting the digestive system. When dealing with complex cases like intestinal blockages or perforations, surgery becomes the primary treatment option. However, surgery doesn’t offer a complete cure, and the possibility of recurrence remains. To manage CD recurrence after surgery, various treatment choices are available, including steroids, monoclonal antibodies, immunomodulators, and further surgery. Regrettably, the current body of evidence doesn’t definitively establish which of these treatments is the most effective and safe. Thus, our research aims to provide insights into the Validity and security of different treatment approaches for managing CD recurrence after surgery.

Methods

Search of EMBASE, PubMed, Web of Science Core Collection and the Cochrane Central Register of Controlled Trials will be conducted to include researches that examine the validity of treatments for recurrent CD after surgery. Our analysis will distinguish between two types of studies: randomized controlled trials (RCTs) and non-randomized studies with at least two different treatments, each evaluated separately. We will employ Bayesian network meta-analyses to systematically compare the effectiveness and safety of these treatments. Additionally, subgroup analyses will be performed according to recurrence status and postoperative prophylactic medication. To clarify the variation of studies, sensitivity analyses will be performed. And we may use meta-regression as an additional approach if relevant data are available. We will also rigorously access the certainty of evidence using the Grading of Recommendations, Assessment, Development, and Evaluation framework.

Discussion

This analysis will provide a comprehensive assessment of the latest evidence on available treatments for patients with postoperative recurrence of CD, which will provide recommendations for clinical practice.

Trial registration

Systematic review registration

INPLASY2023110021. (DOI: 10.37766/inplasy2023.11.0021).
Egy Tömörkény-elbeszélés kommentárokkal és mítoszi távlatban
Authors: Simoncsics Péter
Published: October 2024

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A győzelem jelképei
Authors: Újvári Edit
Published: October 2024

A győzelem számos jelképe ismert a különböző kultúrákban. Európában az ókori mediterrán eredetű, elsősorban az antikvitásban kialakult szimbólumok hagyományozódtak tovább, részben módosulva, új jelentésekkel kiegészülve. A kereszténység az új győzelmi jel mellett a görög-római diadal-motívumok átértelmezésének érdekes példáit mutatja. A tanulmány ezekre az ókortól kezdődően átörökített jelképekre és a jelentésekben történő módosulásokra fókuszál. Bár az elvont fogalmak esetében jellemzően a közmegegyezés által kanonizált szimbólum jelek a tipikusak, a győzelmi jelképek azért is érdekesek, mert ősi, ösztönös kifejeződések, gesztusjelek fennmaradása is kimutatható, amelyek keveredhettek, kiegészülhettek későbbi korok győzelmi motívumaival.
befejezetlen interjú margójára
Authors: Bányai Éva
Published: October 2024

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Humanizing Learning: Implementing the Humanistic Approach in Inclusive Islamic Education at SD Muhammadiyah Wringinanom Gresik
Authors: Patty Muh Akbar , Prastowo Andi , Sahmat Sulhu Diah Rafidiah
Published: October 2024

Abstract: Humanism is one meaningful learning approach that engages students in learning activities. In facing the challenges of inclusive education in Indonesia, implementing Humanistic Learning Theory becomes very relevant and strategic. This research explores the implementation of a humanistic approach in inclusive classrooms at SD Muhammadiyah Wringinanom, Gresik. Using a descriptive qualitative method, data were collected through interviews, classroom observations, and document analysis. The study focused on how humanistic principles, such as respect for individuality, emotional well-being, and social development, are applied in inclusive education. Results highlight the effective use of student-centered learning and the importance of positive teacher-student relationships. However, challenges remain in the lack of specialized teachers for students with disabilities. The study emphasizes the need for more teacher training and resource allocation to improve inclusive education further. Collaboration between teachers, parents, and external organizations is essential for successfully implementing humanistic principles in Islamic educational contexts. Further research is recommended to explore the long-term benefits of the humanistic approach for diverse learners.
Abstrak: Humanistik merupakan salah satu pendekatan pembelajaran yang sangat bermakna dengan menjadikan siswa sebagai subjek yang aktif dalam kegiatan pembelajaran. Dalam menghadapi tantangan pendidikan inklusi di Indonesia, implementasi Teori Belajar Humanistik menjadi sangat relevan dan strategis. Penelitian ini mengeksplorasi implementasi pendekatan humanistik di kelas inklusif SD Muhammadiyah Wringinanom, Gresik. Menggunakan metode deskriptif kualitatif, data dikumpulkan melalui wawancara, observasi kelas, dan analisis dokumen. Penelitian ini berfokus pada penerapan prinsip-prinsip humanistik, seperti penghargaan terhadap individualitas, kesejahteraan emosional, dan pengembangan sosial dalam lingkungan pendidikan inklusif. Hasil penelitian menunjukkan penerapan pembelajaran berpusat pada siswa yang efektif dan pentingnya hubungan positif antara guru dan siswa. Namun, tantangan masih ada dalam ketiadaan guru khusus bagi siswa berkebutuhan khusus. Penelitian ini menekankan perlunya pelatihan guru yang lebih intensif dan alokasi sumber daya untuk meningkatkan pendidikan inklusif. Kolaborasi antara guru, orang tua, dan organisasi eksternal sangat penting untuk keberhasilan penerapan prinsip-prinsip humanistik dalam konteks pendidikan Islam. Penelitian lanjutan dianjurkan untuk mengeksplorasi manfaat jangka panjang pendekatan humanistik bagi siswa dengan kebutuhan beragam.
Therapeutic efficacy and short-term durability of trans-urethral amniotic bladder injections for the treatment of refractory COVID-associated cystitis
Authors: A. Considine Jack , O’Hollaren Kyle , Knapp John , Radoiu Codrut , Liaw Aron , Dhar Nivedita
Published: October 2024

Introduction: COVID-19-associated cystitis (CAC) may arise following a COVID-19 infection and is characterized by the development of novel or worsening overactive bladder (OAB). CAC is possibly associated with bladder mucosal damage and the release of pro-inflammatory cytokines, resulting in inflammation and fibrosis of the bladder wall. Amniotic membrane (AM) has been shown to possess anti-inflammatory and anti-fibrotic properties and might potentially be beneficial for CAC. This study investigated the safety and efficacy of bladder injections of AM in CAC patients with resistant OAB symptoms. Methods: Five CAC patients, with an average age of 73 ± 1.0 years and a median disease duration of 2.4 years, received intra-detrusor injections of 100 mg micronized AM under general anesthesia and were followed for 20 weeks. Key urodynamic measures (involuntary detrusor contraction and maximum cystometric capacity) were determined to evaluate treatment response. Quality of life (QOL) was assessed using the OAB assessment tool, and safety was analyzed. Results: All five patients showed improved urodynamic bladder function and significantly improved QOL improvements. The improvement was evident from 4 weeks post-treatment and sustained until 12 weeks. Symptoms re-surged at 20 weeks. No safety concerns arose during the study. Conclusion: The observed improvements in symptom scores and bladder volume parameters highlighted the promise of AM bladder injections as a viable intervention for CAC patients with refractory OAB symptoms. Comprehensive studies are needed to validate its therapeutic potential, and treatment protocol refinement is warranted to address the observed reduction in efficacy over time.
Gradual Loss of DNA-PK Activity from the Cytoplasm Is Coincident with the Nuclear Translocation of Its Activator Ku during Early Development of Xenopus laevis
Authors: Kanungo Jyotshnabala
Published: October 2024

DNA-dependent protein kinase is a serine/ threonine kinase consisting of a catalytic subunit, p460, and a regulatory subunit called Ku (p80/p70). DNA-dependent protein kinase plays a role in transcription, non-homologous recombination, and DNA repair. Previous data have shown the presence of DNA-dependent protein kinase in Xenopus oocytes and changes in its activity during vitellogenesis. Metabolic labelling studies have shown that the increased enzyme activity in vitellogenic oocytes correlates with increased levels of Ku protein, and compared to the preand early-vitellogenic oocytes, vitellogenic and post-vitellogenic oocytes show an increased level of DNA-dependent protein kinase activity. Whether DNA-dependent protein kinase activity is altered during early embryogenesis in Xenopus is not known. The present study demonstrates that DNA-dependent protein kinase activity is gradually lost from the cytoplasm in the early embryonic cells of blastulae and gastrulae. The gradual loss of DNA-dependent protein kinase activity during post-fertilization early embryogenesis in Xenopus is consistent with the reports on Arbacia punctulata. Immunohistochemistry of the oocytes at various stages and early embryos (gastrulae) shows that Ku70, a regulatory subunit of DNA-dependent protein kinase, is present both in the cytoplasm and nucleus in the pre-vitellogenic oocytes, full-grown post-vitellogenic oocytes and in the gastrula cells. However, Ku70 appears to accumulate in higher concentrations in the nuclei of gastrula cells. These results suggest that gradual loss of DNA-dependent protein kinase activity from the cytoplasm of the early embryos could be the consequence of Ku translocating to the nuclei that may be necessary for post-zygotic transcription followed by cellular differentiation.
Morphometrical Evaluation of Germ Cell Apoptosis in Infertile Men
Authors: Štiblar-Martinčič Draga
Published: October 2024

Apoptosis associated with programmed cell death plays an essential role in the control of germ cell number in the testes. Although male germ cell apoptosis has been well characterized in different animal models, only a few studies of apoptosis in human testes are presently available. In 43 infertile men with azoospermia of varying aetiology, testicular tissue was obtained by testicular biopsy. Apoptosis of testicular germ cells was determined by the terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling method in situ. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling-positive cells were found in the testicular tissue of all patients with azoospermia, except in Sertoli cell-only syndrome. The apoptotic index was higher in germ cell hypoplasia and in normal spermatogenesis in comparison with germ cell arrest. This study was performed to confirm the presence and determine the frequency of apoptosis in infertile men.
Boundary Element Method for Viscous Flow through Out-phase Slip-patterned Microchannel under the Influence of Inclined Magnetic Field
Authors: Chhabra Vishal , Nishad Chandra Shekhar , Sahni Manoj
Published: October 2024

In this paper, we investigate the impact of an inclined magnetic field of uniform intensity on viscous, incompressible pressure-driven Stokes flow through a slip-patterned, rectangular microchannel using the boundary element method based on the stream function-vorticity variables approach. The present investigation focuses only on the out-phase slip patterning of the microchannel walls. We address two scenarios of slip patterning, specifically large and fine slip patterning, which are determined by the periodicity of the patterning. We utilized the no-slip and Navier’s slip boundary conditions in an alternative manner on the walls. The Stokes equations govern the viscous flow through a microchannel. We assume a very small magnetic Reynold’s number to eliminate the equation of induced magnetic field in the present study. We analyzed the impact of considered dimensionless hydrodynamic parameters, including the Hartman number (Ha), inclination angle (θ)  of the magnetic field, and the slip length (ls
)  on fluid dynamics. In the case of fine slip, we observed significant variations in both velocity and pressure gradient, in contrast to large slip patterning. Fine slip patterning significantly increases the shear stress at slip regimes, while large slip periodicity significantly reduces it at no-slip regimes. The present investigation has several notable implications, such as regulation and advancement of mixing and heat transmission within microfluidic systems.
Laboratory evaluation of 15 entomopathogenic fungal spore formulations on the mortality of Drosophila suzukii (Diptera: Drosophilidae), related drosophilids, and honeybees
Authors: Toledo-Hernández Ricardo A. , Lasa Rodrigo , Montoya Pablo , Liedo Pablo , Sánchez Daniel , Rodríguez Douglas , Pulido Mónica , Toledo Jorge
Published: October 2024

The drosophilids Drosophila suzukii (Matsumura), Drosophila melanogaster Meigen and Zaprionus indianus Gupta (Diptera: Drosophilidae), are common pests of Mexican berry plantations. Attract-and-infect-based application strategies using entomopathogenic fungi (EPF), which are more environmentally friendly than synthetic chemical pesticides, are currently under evaluation for their potential at controlling insect pests, as compared to synthetic pesticides. In this study, we evaluated 15 EPF formulations against D. suzukii adults to determine which formulations would work best in an attract-and-infect device in terms of spore accumulation, pathogenicity, and mortality. Formulations of Beauveria bassiana (Balsamo) Vuillemin (Hypocreales: Cordycipitaceae), Cordyceps javanica (Friederichs & Bally) (Hypocreales: Cordycipitaceae), and Metarhizium anisopliae (Metschnikoff) Sorokin (Hypocreales: Clavicipitaceae) spores exhibited the highest levels of conidia attachment, pathogenicity, and virulence, making them effective against D. suzukii. In a subsequent experiment, these formulations were evaluated against D. melanogaster, Z. indianus, and the honey bee, Apis mellifera L. (Hymenoptera: Apidae). Our results revealed that the formulations containing C. javanica and M. anisopliae were highly virulent not only against D. suzukii, but also against D. melanogaster and Z. indianus, with minimal impact on honey bees. Our results showed that spore formulations of M. anisopliae and C. javanica were the most promising entomopathogens for further testing of attract-and-infect devices to manage D. suzukii, D. melanogaster and Z. indianus in berry crops.
Digitalization of administrative work at home
Authors: Dethier Erik , Stevens Gunnar , Boden Alexander
Published: October 2024

People must perform bureaucratic, administrative work in daily life, such as applying for official documents, concluding contracts, organizing purchases, managing pension plans, etc. This work is time-consuming and unequally distributed in the household. At its best, it is perceived as boring; at its worst, it is mentally and emotionally stressful, leaving people overwhelmed and unable to fulfill their obligations. People can benefit from the digitalization of domestic bureaucracy automating repetitive tasks, reducing mental effort, and saving time for leisure activities. In recent years, there has been a need for more empirical knowledge about the use of technology or the working environment for this purpose. This paper presents insights from an online survey with 617 socio-demographically distributed participants highlighting the devices, tools, special software, and common places people favor for accomplishing these office-like household chores. Our results provide a solid empirical basis that not only quantifies previous qualitative results now using the German adult population but also offers orientation for further in-depth research as well as design.
Eigenschaften von Hör- und Lesetexten in Hochschulzugangssprachtests am Beispiel der DSH
Authors: Möhring Jupp
Published: October 2024

Die DSH-Spezifikationen zu den Prüfungsteilen Hören und Lesen bieten den DSH-Standorten Anhaltspunkte zur Gestaltung von Inputtexten. Gleichzeitig verbleibt viel Spielraum zur konkreten Ausgestaltung von Texten und Aufgaben bei den DSH-Autorinnen und -Autoren und wenig ist über die Eigenschaften und die Vergleichbarkeit der an den Prüfungsstandorten genutzten Texte bekannt. In diesem Beitrag werden 115 authentische Hör- und Lesetexte von elf DSH-Standorten1 auf ihre Lesbarkeit und weitere lexikalische Eigenschaften hin untersucht.
Zur Berücksichtigung spezifischer Bedürfnisse in Prüfungen zum Nachweis der sprachlichen Studierfähigkeit unter dem Anspruch eines inklusiven Bildungssystems
Authors: Yildirim Hülya , Niehaus Kevin , Masalon Ksenia
Published: October 2024

Im Mittelpunkt des vorliegenden Beitrags steht die Auseinandersetzung mit spezifischen Bedürfnissen in Prüfungen zum Nachweis der sprachlichen Studierfähigkeit. Aufbauend auf den Erfahrungen der Teilnehmenden mit der Prüfung sollen Impulse abgeleitet und diskutiert werden, die für die zukünftige Berücksichtigung spezifischer Bedürfnisse von Relevanz scheinen. Aber auch damit verbundene Fragen, die das Spannungsverhältnis zwischen Standardisierung und Individualisierung betreffen, werden aufgeworfen. Diese sind letztlich für alle Sprachprüfungsverfahren bedeutsam.
The Time of the Chancery: Normative and Discretionary Dating in 7th–8th-century Arabic Epistolography
Authors: Garosi Eugenio
Published: October 2024

One of the signs of the early implementation of shared bureaucratic practices across the newly established Islamic empire are the highly standardized formulaic features of seventh- and eighth-century Arabic official documents. At the same time, the use of dates and dating formulae appears to have been less closely regimented compared to other components of Arabic documentary templates. This article offers an overview of the different dating formulae used in the early Islamic official correspondence with an emphasis on patterns of difference (e. g., how norms for date formulations varied depending not only on the function of the document but also on the issuing office, scribe, recipient, direction of the communication). In particular, it is argued that the comparatively high variability of dating formulae suggests that the dates were not considered to be a structural part of documentary templates and were therefore more prone to respond to social variables, such as corporate designs of single chanceries and scribal styles. Furthermore, evidence suggests that dating formulae (or the absence of a date) reflect the register of written communication.
Rayḥāna “The Mad”: Her Persona and Poetry
Authors: Hammond Marlé , van Gelder Geert Jan
Published: October 2024

This article on the intriguing second-/eighth-century Iraqi Muslim ascetic poet Rayḥāna al-Majnūna, or Rayḥāna “The Mad,” consists of two parts: (1) a study contextualizing her persona and corpus and arguing that her historical and folkloric identity as a black woman poet situates her at a creative nexus of wisdom, madness, and worship, and (2) appendices including translations of her poems and their anecdotal frameworks as they are preserved in three medieval sources: ʿUqalāʾ al-majānīn by Abū al-Qāsim al-Ḥasan ibn Ḥabīb al-Nīsābūrī (d. 406 H/1015–16 CE), Ṣifat al-ṣafwa by Ibn al-Jawzī (d. circa 597 H/1201 CE), and Talkhīṣ al-mutashābih by al-Khaṭīb al-Baghdādī (d. 463 H/1071 CE). It is hoped that the translations will give the reader direct knowledge of Rayḥāna’s distinctive poems and that the contextual analysis will support informed interpretations of both the poems and the narratives in which they are embedded through its attention to various discursive prisms including textual traditions relating to mental health, religious devotion, and women’s writing.
Binding and Unbinding:
The Knotted Serpents on the Lining of the So-called Mantle of Roger II (528/1133–4)
Authors: Kuehn Sara
Published: October 2024

In a recent thought-provoking analysis of the iconography on the exterior of the Mantle of Roger II (r. 1105–1154), the Norman ruler of Sicily and southern Italy, William Tronzo has advanced a compelling hypothesis suggesting that the Mantle may actually have been intended to serve as Roger’s shroud. This article examines the intriguing but rarely discussed figured silks found within the Mantle’s lining to assess whether their iconography aligns with Tronzo’s hypothesis, which focuses primarily on the Mantle’s exterior. The interior consists of a patchwork of silk fragments inserted into the famous garment as a relic-like lining, revealing a fascinating but often overlooked iconography: knotted serpents. Continuing an earlier practice, the repetition of the knotted serpent motif appears to have been deliberately employed to reinforce a beneficial effect, perhaps invoking the notion of unceasing, everlasting protection. This study contextualizes the richly multivalent symbol of the knotted serpent within the broader realm of southern Italian iconography, as well as its significance in the wider Mediterranean world and beyond. In particular, the research incorporates a fascinating discovery: a previously unnoticed silk fragment from the Afghan province of Samangan, now in the Al-Sabāh Collection in Kuwait. This fragment bears striking similarities to the textiles used in the cloak’s lining, further enriching our understanding of its cultural and historical import.
Delegation of Authority to Human Beings: A Late Safavid Theologian’s Account on the Legislative Meaning of

Tafwīḍ
Authors: Azadani Zakieh
Published: October 2024

In this article, I intend to examine an account of human free will suggested by one of the most prominent figures in religious institutions during the Safavid reign, which had a long-term effect on subsequent discussions on the subject. Muḥammad Bāqir Majlisī (1627–1699), a renowned theologian, muḥaddith, and jurist who played a significant role in shaping Shīʿism in Iran, emphasized human free will (ikhtiyār) in his various works. While he considers it a self-evident truth, Majlisī attempts to justify human agency in voluntary activities through his arguments. However, it appears that his emphasis on human free will is primarily aimed at demonstrating that individuals are legally bound. Due to the limitations of human intellect, Majlisī argues that humans cannot be considered competent to create the legal rules they must follow. Consequently, individuals are not authorized to determine their own obligations even though they are responsible for their actions. Thus, while Majlisī was determined to establish that humans possess free will, he believed that individuals were not allowed to exercise this freedom in the realm of social and political affairs.
The Challenges of a Purchase by the Berlin Papyrus Collection in 1926
Authors: Sonego Leonora
Published: October 2024

Where do Arabic papyri come from? The article shifts the question to “How did the Arabic papyri reach modern institutions, and why do we know so little about their provenance”? In an exemplary way, the purchase of 142 texts from Maurice Nahman in Cairo by the Berlin Papyrus collection in 1926, which is exceptionally well documented, will be discussed here. The collection was then headed by Wilhelm Schubart, who was assisted in this purchase by Adolf Grohmann and Ludwig Borchardt. It turns out that several of the steps from the findspot to the museum were settled on the margin of legal norms, which meant that the actors had an interest to disguise business partners and archeological contexts. For this reason, most acquisitions cannot be traced back to the original findspot. If we intend to reconstruct groups of related documents, it will probably be easier to analyze internal features, like the mentioned persons and the style of handwriting. Museum archives can then complement this information.
One special kind of Kloosterman sum and its fourth-power mean
Authors: Zhang Wenpeng , Wang Li , Liu Xiaoge
Published: October 2024

This article aims to investigate the calculation problem of the fourth-power mean of the specific Kloosterman sums by utilizing analytic methods and the properties of classical Gauss sums. It provides a captivating calculation formula for this purpose. Additionally, an effective method for studying high-power mean of Kloosterman sums is introduced in this research.
Y27632 induces tongue squamous cell carcinoma cell apoptosis through MAPK-ERK/JNK signal
Authors: Zhang Xiuling , Zu Tingjian , Wen Jie , Zhou Qian
Published: October 2024

Objectives

ROCK signaling is considered a therapeutic target for oral squamous cell carcinoma (OSCC). Y27632, a well-established ROCK inhibitor, has previously been reported to block oral squamous cell carcinoma cell growth and has shown cell type dependence in the treatment of other cancers. TP53 is one of the most frequently mutated genes in head and neck cancer. Here, we aim to investigate the role of Y27632 in wild-type and p53 mutant (R175H) SCC9 cells.

Methods

The p53-mutation (R175H) and p53-null SCC9 cell line were conducted, then, CCK8, colony formation, wound-healing assays, and transwell assay were employed to investigate the role of Y27632 in wtp53 and mutp53 SCC9 cells. The effects of Y27632 in SCC9 cells were also confirmed by the knockdown of ROCK1/2. Additionally, cell cycle and apoptosis were assessed using flow and western blot analysis. The impact of Y27632 on cell senescence was confirmed through the senescence-associated β-gal staining. Furthermore, the inhibition of Y27632 was examined in vivo using tumor-bearing nude mice.

Results

Our study demonstrates that Y27632 effectively impeded the proliferation of tongue squamous cell carcinoma (TSCC) cells in vitro and in vivo. Additionally, the proliferation and migration of wtp53 and mutp53 SCC9 cells were also significantly suppressed by Y27632 or ROCK siRNA in vitro. Mechanistically, Y27632 induced apoptosis in SCC9 cells via the MAPK-ERK/JNK signaling pathway.

Conclusions

Our data demonstrated that Y27632 induces apoptosis in SCC9 cells via the MAPK-ERK/JNK signaling pathway, regardless of the presence of p53 mutant variants (R175H). This will provide a potential therapeutic drug for TSCC treatment in the future.
Assessment and multi-scenario simulation of ecosystem service values in Southwest China’s mountainous and hilly region
Authors: Zhu Bing , Yang Yan , Meng Yu , Chen Juan
Published: October 2024

The southwestern mountainous and hilly regions of China are vital ecological barriers upstream of the Yangtze River. Assessing and simulating changes in ecosystem service value (ESV) in this area is essential for ensuring sustainable ecological development. In this study, our purpose was to evaluate and simulate the spatial patterns as well as trends in the changes shown by the ESV in Yanting County, China, from 2020 to 2030 via a grid-scale using the equivalent factor method and the Markov–patch-generating land use simulation model. The results indicated that (1) from 2020 to 2030, forest, cultivated, and construction lands would be the main types of land use. (2) In 2030, the projected ESVs in Yanting County under the as-usual, low-carbon, and shared development scenarios were 5.31, 5.30, and 4.99 billion RMB, respectively. Compared to the 2020 ESV of Yanting County, the as-usual scenario and low-carbon scenario ESVs increased. The shared development scenario ESVs decreased. It reflects the contra-diction between urbanization, industrialization, agricultural production, and ecological protection in Yanting County. The spatial distribution of the ESVs of all three scenarios showed an agglomeration trend. (3) Given the background of national food security and carbon peaking and carbon neutrality, the setting of a low-carbon development scenario combined with a shared development scenario appears to be more suitable for the future development of Yanting County, which is conducive to the rational planning of land-use patterns and the sci-entific growth of ESV in Yanting County. This study underscores the critical importance of integrating ESVs in sustainable land-use planning and management, and provides a reference for the rational use of land resources, land spatial planning, and policy-making for ecological protection in Yanting County.
The BIAD Standards: Recommendations for Archaeological Data Publication and Insights From the Big Interdisciplinary Archaeological Database
Authors: Reiter Samantha S. , Staniuk Robert , Kolář Jan , Bulatović Jelena , Rose Helene Agerskov , Ryabogina Natalia E. , Speciale Claudia , Schjerven Nicoline , Paulsson Bettina Schulz , Lee Victor Yan Kin , Canteri Elisabetta , Revill Alice , Dahlberg Fredrik , Sabatini Serena , Frei Karin M. , Racimo Fernando , Ivanova-Bieg Maria , Traylor Wolfgang , Kate Emily J. , Derenne Eve , Frank Lea , Woodbridge Jessie , Fyfe Ralph , Shennan Stephen , Kristiansen Kristian , Thomas Mark G. , Timpson Adrian
Published: October 2024

This article presents a series of recommendations for the publication of archaeological data, to improve their usability. These 12 recommendations were formulated by archaeological data experts who mined thousands of publications for different data types (including funerary practices, accelerator mass spectrometry dating, stable isotopes, zooarchaeology, archaeobotany and pathologies) during the initial construction of the Big Interdisciplinary Archaeological Database (BIAD). We also include data harmonisation vocabularies utilised for the integration of data from different recording systems. The case studies we cite to illustrate the recommendations are grounded in examples from the published literature and are presented in a problem/solution format. Though practically oriented towards the facilitation of efficient databasing, these recommendations – which we refer to as the BIAD Standards – are broadly applicable by those who want to extract scientific data from archaeological information, those who work with a specific region or theoretical focus and journal editors and manuscript authors. We anticipate that the use of the BIAD Standards will increase the usability, visibility, interoperability and longevity of published data and also increase the citations of those publications from which data were mined. The Standards will also help frame a unified foundation to support the continued integration of the natural sciences with archaeological research in the future.
How and why does inner resignation (quiet quitting) impact service innovation behavior? A moderator role of ethical leadership
Authors: Ustun Ferda , Koca Balli Ayse Ipek , Balli Erdinc
Published: October 2024

Tourism enterprises are labor-intensive, and the service innovation behavior of employees plays an important role in keeping these enterprises ahead of their competitors. Inner resignation (IR) is a relatively new concept in organizational life, and it is a situation that should be prevented due to its negative impact on the organization. In this study, the moderating role of ethical leadership (EL) in reducing the negative effect of inner resignation on service innovation behavior (SIB) was examined with a cross-cultural comparison for Turkish and German tourism employees. A total of 743 employees working in hotels in Turkey and Germany were surveyed using a questionnaire. The results of the research show that employees’ inner resignation has a negative impact on their service innovation behavior. On the other hand, ethical leadership plays a moderating role in the effect of inner resignation on service innovating behavior. The moderator role of ethical leadership perceptions in this relationship was also examined separately for German and Turkish employees due to cultural differences. While the moderating role of ethical leadership in the effect of German employees’ inner resignation on service innovating behavior was found to be statistically significant, this role was found to be insignificant for Turkish employees.
How does digital transformation affect innovation quality?
Authors: Pu Tingqian , Zulkafli Abdul Hadi
Published: October 2024

In the digital era, digital transformation is disrupting traditional business models and innovation activities. Numerous firms have expedited their endeavors in digital transformation to augment their manufacturing capabilities, operational efficiency, and competitive standing. Despite the increasing scholarly attention on the pivotal role of digital transformation in economic progress, there exists a paucity of research delving into the intricate nexus between digital transformation and innovation quality. The objective of this study is to investigate the relationship between digital transformation and innovation quality. Leveraging annual report data and patent information from Chinese listed companies spanning from 2012 to 2021, we have identified that digital transformation significantly enhances innovation quality. Interestingly, upon further investigation into the relationship between the five sub-dimensions of digital transformation (artificial intelligence, blockchain, cloud computing, big data, and digital technology applications) and innovation quality, positive and significant correlations were observed with artificial intelligence, cloud computing, big data, and digital technology applications, while blockchain did not exhibit a significant impact. Furthermore, the study reveals that the impact of digital transformation on innovation quality varies depending on property rights and regional location. Specifically, this promotional effect is significant only in non-state-owned enterprises and in the central and eastern regions. Overall, this paper enriches the research on digital transformation and innovation quality, providing valuable insights to promote the advancement of digital transformation levels for better serving the high-quality development of the real economy.
The role of technology in modern industrial processes: a comparative analysis of automated, automatic and mechanical systems
Authors: Smyk Denys D. , Burak Nazarii E.
Published: October 2024

In the modern technological sphere, systems are categorized into various types based on their level of complexity and functional capabilities. The primary types are mechanical, automatic, and automated systems. Each of these types has its unique characteristics and areas of application. Mechanical systems are the simplest of all. They consist primarily of physical components such as gears, levers, and springs, which interact to perform specific tasks. These systems typically lack built-in control or regulation mechanisms, and their operation is based on basic mechanical principles. Examples of mechanical systems include simple clock mechanisms or traditional measuring devices. Automatic systems represent an evolutionary step beyond mechanical systems, as they include elements for automatic control. These may be electrical or electronic components that enable the system to perform certain operations without direct human intervention. For example, automatic doors or thermostats that regulate room temperature are examples of such systems. They can respond to changing conditions and perform tasks based on predefined parameters. Automated systems, in turn, are the most complex and integrated. They combine automatic control with software and advanced management systems, allowing them to adapt to changing environmental conditions and make decisions independently. Automated systems may include elements of artificial intelligence and machine learning, enabling them to perform complex tasks such as data processing or optimizing production processes. Examples include industrial robotic lines or management systems in distribution networks. Thus, the main differences between these systems lie in their level of complexity and functional capabilities: mechanical systems are based on simple physical principles, automatic systems contain elements of automatic control, and automated systems provide a high level of integration and autonomy.
Vulnerability module in the multi-level ontology of risk assessment of Wireless Sensor Networks
Authors: Shtilman Pavlo R. , Tishin Petr M.
Published: October 2024

This work presents the development of a vulnerability module within a multi-level ontology for risk assessment in wireless sensor networks (WSNs) used in industrial environments. WSNs consist of multiple sensor nodes with microcontrollers, sensors, communication devices, and power sources, playing a key role in monitoring, diagnostics, and managing industrial processes. Their main advantages include reduced costs due to the lack of cabling and ease of scaling by adding new nodes. However, WSNs face significant challenges, including limited power supply, vulnerability to electromagnetic interference, low bandwidth, and exposure to cyber-attacks. These issues make them less suitable for real-time systems where fast and reliable data transmission is critical. The vulnerability module developed in this study addresses these challenges by identifying weaknesses, analyzing potential threats, and assessing risks using logical rules. These rules assess various network components such as devices, communication protocols, and external factors like physical access and radio interference. The module continuously monitors the network, detects new vulnerabilities, and provides real-time feedback to the risk assessment module, suggesting measures to mitigate risks. This enhances the security and reliability of WSNs in industrial applications. In conclusion, the vulnerability module within the multi-level ontology provides a structured approach to identifying and mitigating risks in WSNs. Despite the inherent vulnerabilities of WSNs, advancements in security protocols and energy efficiency make them increasingly viable for industrial automation and optimization.
Managing and editing UML documents: structure, integration, automation
Authors: Nikitchenko Maksym I.
Published: October 2024

Unified Modeling Language (UML) plays an important role in the modern software development process by offering standardized methods for visual modeling, analysis, and design of complex systems. This paper discusses the main aspects of storing, editing, and integrating UML documents with integrated development environments (IDEs). The main focus is on comparing the two main formats for storing UML models – XML Metadata Interchange (XMI) and JavaScript Object Notation (JSON). XMI, being an official standard developed by Object Management Group, provides a high degree of detail and compatibility with various UML tools, making it preferable for large and complex projects that require support for the full UML specification. At the same time, JSON is simple and flexible, which makes it suitable for projects where speed of development and ease of integration are important, although it is inferior to XMI in describing complex aspects of UML models. The paper analyzes in detail the methods of editing UML documents, including manual editing and automated approaches, using APIs and scripts. Manual editing is useful when you need to make small changes to the structure of a UML document, but it can be time-consuming and error-prone when working with large projects. Automation, on the other hand, provides effective tools for mass editing and generating UML elements, which significantly speeds up development and minimizes the likelihood of errors, especially since modern tools such as StarUML offer the necessary tools for programmatically modifying UML documents by integrating them into development processes. Combining of UML documents with integrated development environments also plays a key role in increasing development efficiency, as this allows automating code generation based on UML models, maintaining synchronization between code and diagrams, and facilitating visualization and documentation of architectural solutions. Despite the significant advantages, there are challenges associated with limited support for all UML features and potential conflicts between models and code. This only emphasizes the need for further research in this area. Prospects for further research include the development of new methods and tools for working with UML documents, improving their integration with development environments, and using artificial intelligence to automate the analysis and design of UML models. Attention should also be paid to the using of UML with continuous integration processes, which can significantly increase the flexibility and adaptability of software development. Thus, the study of the structure of storing, editing, and integrating UML documents is an important area for optimizing the design and development of modern software systems.
Software architecture for implementing a personal budget manager with artificial intelligence
Authors: Shuryhin Kostiantyn A. , Zinovatna Svitlana L.
Published: October 2024

The rapid adoption of artificial intelligence (AI) in consumer markets has led to the need for extensive research into its impact on consumer behavior, particularly in how it exploits cognitive biases. This raises ethical questions and highlights the need to balance such influences with AI systems that help consumers, not manipulate them. The development and implementation of an intelligent financial management system, which not only automates financial processes, but also integrates AI-driven tools to support better financial decision-making, contributes to solving these problems. The work contains a description of the development of the architecture of an intelligent financial management system, which is aimed at solving problems related to financial illiteracy, the complexity of financial markets, and the impact of cognitive biases on financial decision-making. The system provides for the use of modern technologies of artificial intelligence and machine learning to automate financial processes and provide users with personalized recommendations. The development of a system based on microservice architecture requires the use of certain architectural patterns that ensure efficiency, reliability and scalability, so the work was based on a critical analysis of modern architectural paradigms, such as microservice architecture and Event-Driven Architecture. The implementation of AI supports ethical guidelines that prioritize transparency, fairness and consumer autonomy, i.e. ensure that the AI ​​system is free from bias, actions can be easily interpreted by users. The methodology of this research is based on an interdisciplinary approach that combines the analysis of architectural solutions, methods of machine learning and artificial intelligence with methods of ensuring the reliability and scalability of software systems.