bluuebunny/crossref_metadata_2025 huggingface dataset:
A Review of Mendelian Randomization in the Presence of Weak Instrumental Variables; Statistical Methods and Challenges
Authors: Habibi Danial , Daneshpour Maryam S , Mansourian Marjan , Akbarzadeh Mahdi
Published: January 2025

Introduction: Mendelian randomization (MR) assesses the causal effect of risk factors by using genetic variations as instrumental variables (IV) in nonexperimental data. IV strategies are one of a few available methods for determining causal effects in the absence of specific knowledge of all confounders in the exposure- outcome relationship. To use an IV as a legitimate instrumental variable, it must meet the following criteria: relevance, exchangeability, and exclusion restriction. A weak instrument is a circumstance in which there is a piece of weak statistical evidence for an association between IV and exposure. Weak instruments cause significant issues, including (i) insufficient statistical power to hypothesis testing, (ii) increasing bias with deviation from IV assumptions, and (iii) asymptotic estimation of standard errors and confidence intervals. Therefore, in this study, we intend to introduce the Mendelian randomization method, weak instrumental bias, and statistical remedy methods used in this bias.
Methods: Current study was conducted by using Medline/PubMed, Scopus, Web of Sciences and Google Scholar.
Results: This review provides a comprehensive description of the principles of MR, and a guide to basic MR methodology. To deal with these challenges, the bulk of the review considered statistical remedies. The review ends with a section that details the practical limitations, and recommendations regarding MR and the weak instruments
Conclusion: Depending on the type of data, several solutions can be used in one and multiple IV. Moreover, it can be used in solutions in the design and analysis phase to minimize the effects of weak instruments
Bayesian Spatio-Temporal Modeling of Hyperlipidemia Risk in IRAN; A Repeated Cross- Sectional Analysis
Authors: Alinia Shayesteh , Mansouri Kamyar , Arsang-Jang Shahram
Published: January 2025

Introduction: The incidence of hyperlipidemia in Iran is on a consistent rise, potentially contributing significantly to increased susceptibility to cardiovascular diseases and other health complications linked to elevated blood lipid levels. This study employs hierarchical Bayesian model to assess the heightened lipid risk on a broader scale across Iran's provinces.
Methods: This study included individuals diagnosed with hyperlipidemia from all provinces of Iran in 2019. The primary focus of the investigation included essential variables such as the mean age, gender distribution, and the documented incidence of hyperlipidemia cases in each province. Population data, stratified by province, age group, and gender, were sourced from the Iranian Statistics Center database. The analysis employed the Besag-York-Mollié (BYM) model, with parameter estimation executed through the Hamiltonian Monte Carlo method.
Results: In this investigation, the prevalence and spatial distribution of hyperlipidemia were explored within a diverse population of 1,609,538 patients across various regions in Iran. The relative risk of hyperlipidemia surpassed 1 in 16% of Iranian provinces (Posterior probability [PP] > 0.8), with a calculated 95% Confidence interval (CI) of 0.304 to 0.879. The overall prevalence of hyperlipidemia was determined to be 0.815. Significant heterogeneity in hyperlipidemia was identified among different provinces, with Tehran exhibiting the highest relative risk (RR=1.701; 95% CrI: 1.69, 1.713). Notably, gender (RR=1.008; CI: 1.007, 1.009 for males and RR=1.005;CI: 1.003, 1.007 for females) and age were not found to have a statistically significant effect on the relative risk of the disease.
Conclusion: In conclusion, the study sheds light on the spatial dynamics of hyperlipidemia in Iran. 16% of provinces displayed a heightened relative risk, emphasizing the need for targeted public health strategies.
Barriers to Accessing Dengue Healthcare: A Multicenter Survey from Dhaka, a Major Den- gue Hotspot in Bangladesh
Authors: Nishan Nahid Hassan , Ahmed M Z E M Naser Uddin , Oishy Sayeda Jahan , Alam Aria , Mashreky Saidur Rahman
Published: January 2025

Introduction: Dengue fever in Bangladesh, particularly in Dhaka, faces significant healthcare access barriers. Understanding these barriers is crucial for targeted interventions. Therefore, this study aims to analyze the barriers to accessing dengue healthcare through a multicenter survey in Dhaka, a major dengue hotspot in Bangladesh.
Methods: This cross-sectional study was employed throughout the study. The study was conducted in Dhaka City. This study used two-stage stratified sampling based on hospital type (public/private) and randomly selected 16 hospitals (7 public and 9 private), focusing on patients admitted with dengue. A total of 101 patients comprised the final sample. Data were collected using a structured questionnaire that focused on patient characteristics and challenges in accessing dengue treatment. The main outcomes measured included availability and accessibility access barriers, access barriers related to knowledge, attitudes, beliefs, or practices (KAP), and financial access barriers. Statistical analysis assessed the influence of demographic factors on these access barriers.
Results: The study reveals overall 96.04% of participants perceived dengue as a serious threat. Demographically, the patients mostly lived in urban (85.15%) and varied in education. MANOVA indicates that demographic variables significantly impact access barriers, highlighting age, and education status as influential factors (P-value <0.05).
Conclusion: This study highlights the importance of age and education as key determinants of access barriers in dengue healthcare. Addressing the unique needs of children and older adults, as well as enhancing educational opportunities, could be pivotal in mitigating these barriers.
Developing a Simple Conceptual Causal Model for Predicting Early Recurrence and Mortality after Curative Surgery for Colorectal Cancer Patients
Authors: Ahmadi Samira , Alinia Shayesteh , Mohammadi Zahra , Shirvandeh Farzaneh Rastkar , Asghari-Jafarabadi Mohammad , Mahmoudi Leila , Safari Malihe , Roshanaei Ghodratollah
Published: January 2025

Introduction: Colorectal cancer (CRC) represents the second leading cause of cancer-related mortality. This study focused on the development of a robust conceptual causal model designed to predict early recurrence and mortality following curative surgery in colorectal cancer patients.
Methods: In this retrospective cohort study, we included 284 patients with colorectal cancer (CRC) who underwent surgery at the Imam Khomeini (RA) Clinic in Hamadan, Iran, between 2001 and 2017. Demographic characteristics, treatment modalities, and other relevant data were extracted from patient records. Predictors were analyzed using Generalized Structural Equation Modeling (GSEM) for survival analysis, employing an accelerated failure time (AFT) approach. Both unadjusted and adjusted time ratios (TRs) were calculated using STATA software.
Results: The results of our developed causal model indicated that receiving chemotherapy was significantly associated with a shorter survival time ratio (TR = 0.415, 95% CI: 0.290-0.593), and recurrence time (TR = 0.363, 95% CI: 0.190-0.696). Conversely, patients who underwent multiple chemotherapy sessions exhibited a longer survival time (TR = 2.130, 95% CI: 1.790-2.534) and recurrence time (TR = 2.206, 95% CI: 1.609- 3.023). Age had a direct impact on the recurrence time (TR = 0.758, 95% CI: 0.602-0.955). Additionally, age had a significant direct effect on the receipt of chemotherapy, the cancer site, and the receipt of radiotherapy.
Conclusion: In summary, our study's causal model reveals that chemotherapy shortens survival time but multiple sessions can extend both survival and recurrence times. Age significantly affects recurrence time and chemotherapy receipt. These findings highlight the importance of personalized treatment strategies in colorectal cancer management
Urethral Mucosal Prolapse in A Teenage Girl: Surgical Excision Aand Successful Outcome- A Case Report.
Authors: NWOGU Chidinma Magnus , UGWU Aloy Okechukwu , AKINJO Andrea Oludolapo
Published: January 2025

Urethral prolapse is the complete eversion of the distal urethral mucosa. It is a rare benign condition seen at extreme of age groups being most common with pre-pubertal girls of African descent. It is assumed to be related to hypoestrogenic states of these extreme age groups. It commonly present as vaginal bleeding and genital mass with or without urinary symptoms which may create a false panic over possible sexual assault. Conservative management may be offered to mild or asymptomatic cases while surgery remains the standard treatment modality with faster resolution of symptoms and lower recurrence. We present a case of a 14-year-old with urethral mucosal prolapse who had surgical excision of the prolapse with good outcome.
Detection of Persistence of Foot and Mouth Disease Virus in Local and Crossbred Cattle of Assam
Authors: Brahma Derhasar , Sharma Krishna , Barman Nagendra N. , Borah Probodh , Sharma Rajeev Kumar , Deka Pankaj , Borah Biswajyoti , Doley Monuj K. , Hazarika Ritam
Published: January 2025

Background: This study aimed to investigate the persistence of Foot-and-Mouth Disease Virus (FMDV) in clinically recovered cattle following an outbreak, focusing on both local indigenous breeds (Lakhimi) and crossbred cattle (Holstein Friesian-cross) in Assam.
Methods: A total of 129 cattle (36 local and 93 crossbred), clinically recovered from FMD, were included in the study. Oropharyngeal fluid (OPF) samples (n=178) were collected at various intervals post-recovery. FMDV detection was carried out using three molecular diagnostic techniques: Multiplex PCR, reverse transcription loop-mediated isothermal amplification (RT-LAMP) and SYBR Green real-time PCR, all targeting the FMDV 3D gene.
Result: FMDV was detected in 38 samples (21.35%) by multiplex PCR, 47 samples (26.40%) by RT-LAMP and 49 samples (27.53%) by SYBR Green real-time PCR. While all three methods showed comparable diagnostic accuracy, real-time PCR proved to be the most sensitive, rapid, reliable and cost-effective technique. FMDV persistence was observed in 24.81% (32/129) of cattle up to the 1st month post-recovery, 11.63% (15/129) up to the 3rd month and 1.55% (2/129) up to the 6th month. Local non-vaccinated Lakhimi cattle exhibited higher rates of viral persistence for serotype O, with 33.33% (12/36), 22.22% (8/36) and 5.55% (2/36) showing persistence at the 1st, 3rd and 6th months post-recovery, respectively. In contrast, vaccinated Holstein Friesian-cross cattle, demonstrated lower persistence rates, with 19.23% for Serotype A and 22.39% for Serotype O at the 1st month and 10.45% for Serotype O at the 3rd month post-recovery. Importantly, no transmission of the virus to healthy in-contact animals was detected during the study period.
Statistical analysis (P=0.23, Chi-square=5.57) revealed no significant difference in viral persistence between local and crossbred cattle, suggesting that factors beyond vaccination status might influence FMDV persistence. However, the findings underscore the critical role of vaccination in reducing viral persistence in recovered cattle.
Spesifitas Monoklonal Antibodi Anti Enteropathogenic Escherichia coli (EPEC) dalam Deteksi Bakteri EPEC Penyebab Diare
Authors: Murtini Sri , Budiarti Sri , Wibawan I Wayan Teguh , Satrija Esdinawan Carakantara
Published: January 2025

Diare yang disebabkan oleh bakteri Escherichia coli enteropatogenik (EPEC)
merupakan salah satu jenis penyakit tular makanan yang paling penting di wilayah Asia
Tenggara. Infeksi EPEC menyebabkan gejala diare berlendir yang jika tidak ditangani akan
memicu dehidrasi yang dapat berakhir dengan kematian. Salah satu metode penanganan infeksi
EPEC adalah melalui imunisasi pasif yang mampu menangani infeksi dengan cepat serta dapat
digunakan sebagai pencegahan jangka pendek sebelum infeksi terjadi tanpa memicu resistensi.
Salah satu kandidat antibodi potensial yang dapat digunakan untuk upaya imunisasi pasif adalah
antibodi monoklonal antiprotease. Antibodi ini dipilih karena efektif terhadap seluruh strain
EPEC serta memiliki spesifisitasnya yang tinggi dan dapat diproduksi dalam jumlah yang
banyak dan dalam waktu yang lama. Protease yang digunakan dalam penilitian ini diisolasi dari
bakteri EPEC strain K1.1 yang selanjutnya diimunisasikan ke mencit BALB/c berusia 4
minggu. Mencit yang diimunisasi kemudian diambil limpanya setelah hari ke-69. Splenosit
dipanen dari limpa yang dikumpulkan untuk difusikan dengan sel mieloma guna membentuk
kultur sel hibridoma yang dibiakkan pada media LCT-skim-pati dan media M9. Antibodi hasil
produksi kedua kultur diuji dengan metode dot blot/slot blot untuk mengetahui potensi reaksi
silang, di mana hanya antibodi hasil biakan pada media M9 yang tidak menimbulkan reaksi
silang dengan media ataupun antigen lainnya. Antibodi hasil media ini selanjutnya diukur
titernya menggunakan uji ELISA, di mana diketahui antibodi yang dihasilkan memiliki nilai
titer 10 dan hanya spesifik untuk protease EPEC.
Determinants of Online Transportation Adoption: An Extended UTAUT2 Model with Loyalty Program
Authors: Lesmana Ivan Dika , Panjaitan Erwin Setiawan , Nurjanah Sofiana
Published: January 2025

This study investigates the factors influencing the adoption of online transportation services, focusing on loyalty programs within the UTAUT2 framework. Online transportation platforms, such as Gojek and Grab, have revolutionized service delivery in Indonesia, yet customer retention remains a challenge. Utilizing an extended UTAUT2 model, this research incorporates constructs like Hedonic Motivation, Price Value, and Habit, alongside moderating variables such as Age, Gender, and Experience. Data from 413 active users in Medan City were analyzed using Structural Equation Modeling (SEM) via SmartPLS 3. Results highlight the critical role of loyalty programs in enhancing user engagement and retention by boosting behavioral intentions and actual usage behaviors. Findings offer actionable insights for platform providers to optimize marketing strategies and improve customer loyalty through tailored program designs.
Highly sensitive and robust soft tri-axial tactile sensors enabled by dual inductive sensing mechanismss
Authors: Chen Si , Li Su , Zheng Yiting , Fong Brian , Li Yizong , Dong Penghao , Hwang David , Yao Shanshan
Published: January 2025

Tri-axial tactile sensors that provide real-time information on both normal and shear forces are enabling technologies for tactile perception, which open up new possibilities in robotics, human-machine interfaces, environmental sensing, and health monitoring. Among tri-axial tactile sensors based on different mechanisms, inductive sensors possess good robustness against environmental contamination. Their low sensitivity to normal and shear loads, however, is a critical barrier. This work presents the rational design of soft inductive tri-axial tactile sensors that are capable of distinguishing static or dynamic normal and shear loads, with exceptional tactile sensitivity. Dual mechanisms of Biot-Savart law and Eddy current effect are explored to overcome the long-standing sensitivity issue. In addition, a hybrid coil with non-uniform spacing is designed to generate uniform magnetic fields, addressing the limitations of traditional uniform coils and significantly improving the sensor’s tactile sensitivity. The picosecond pulsed laser scribing technique makes it possible to pattern silver nanowires into inductive coils with high fidelity. A porous compressible layer is adopted to enable adjustable sensitivity and sensing range to meet diverse application demands. Finally, the sensor is integrated between the user’s leg and the orthosis, showcasing the sensor’s capability for real-time monitoring of tri-axial forces and its robustness against environmental objects.
Heterointerface engineering of polymer-based electromagnetic wave absorbing materials
Authors: Liu Shan , Zhou Dengfeng , Huang Fang , He Min , Qin Shuhao , Shi Yongqian , Song Pingan
Published: January 2025

Heterointerface engineering has drawn considerable interest in tuning interfacial polarization and promoting impedance matching. Therefore, it has become a key strategy for optimizing electromagnetic wave (EMW) absorption. This comprehensive review primarily focused on the EMW absorbing strategies of polymer-based materials, emphasizing the critical developments of heterointerface engineering. A possible EMW absorbing mechanism of polymer-based materials was proposed, emphasizing the synergism of multi-components, microstructure design, and heterointerface engineering. Key innovations in structural design such as porous structure, multilayered structure, and segregated structure are explored, highlighting their contributions to enhancing EMW absorption. Also, the review highlights the latest research progress of advanced conductive polymer-based and insulating polymer-based materials with desirable EMW absorption performance; their fabrication methods, structures, properties, and EMW absorption mechanisms were elucidated in detail. Key challenges on polymer-based EMW absorbing materials are presented followed by some future perspectives.
CAPOEIRA ANGOLA E EXTENSÃO: HISTÓRIA, DANÇA, DEFESA E ATAQUE
Authors: Pereira Diego
Published: January 2025

A partir do projeto de Extensão Jogando Capoeira Angola: Quebrando Preconceitos, desenvolvemos a experiência formativa da Capoeira Angola como uma expressão afro-brasileira, trabalhando as dimensões históricas, pedagógicas, musicalidade e movimentação nas dependências da UFT (Campus de Miracema do Tocantins) articulando o tripé acadêmico de ensino, pesquisa e extensão. Metodologicamente as atividades eram realizadas em rodas de conversa, pesquisa de letras de capoeira, debates de filmes sobre antigos Mestres e Mestras, alongamentos e práticas corporais. O projeto refletiu sobre a identidade negra, o preconceito étnico-racial e a sociedade multicultural, tendo em vista que tal atividade é um importante símbolo da identidade africana e afro-brasileira.
DOSSIÊ TEMÁTICO - CORPO EM MOVIMENTO: A EXPERIÊNCIA DA DANÇA NA EXTENSÃO UNIVERSITÁRIA
Authors: Ebling do Nascimento Diego , Seron Kiouranis Taiza Daniela , Da Silva Lopes Sílvia da Silva Lopes , De Souza Ugaya Andresa
Published: January 2025

EDITORIAL.
EXTENSÃO EM MOVIMENTO: DANÇA NA UFRRJ
Authors: Granado Ramon de Oliveira , Pires Valéria Nascimento Lebeis
Published: January 2025

Este estudo objetivou descrever os caminhos percorridos na extensão da/na Universidade Federal Rural do Rio de Janeiro (UFRRJ) e a integração da dança que levou à institucionalização da Companhia (Cia) de Dança UFRRJ. Metodologicamente, é uma pesquisa bibliográfica e documental com abordagem qualitativa de natureza descritiva, onde se apontam as estruturas extensionistas da instituição, com a perspectiva nas ações envolvendo dança e mais especificamente a criação da Companhia. Foi demonstrado que a arte de dançar apresenta um cenário promissor na UFRRJ, além de ser exercida como uma expressão artística, tem buscado promover a sensibilização pessoal, o fortalecimento de relações e a construção de um senso de comunidade.
PEDAGOGIA HISTÓRICO-CRÍTICA E A EDUCAÇÃO ESCOLAR PÚBLICA: CONCEPÇÃO E INDICAÇÕES DE PRÁTICAS FORMATIVAS CONTRA-HEGEMÔNICAS
Authors: Chioca Ipolito Juliana , De Carvalho Roberto Francisco
Published: January 2025

Este artigo é resultado das reflexões suscitadas pelos estudos realizados no curso de extensão Grupo de Estudos da Pedagogia Histórico-crítica (PHC). Esta atividade foi desenvolvida em parceria com a Unioeste com o objetivo de  realizar  um estudo coletivo acerca da Pedagogia Histórico-crítica (PHC) no âmbito do Grupo de Pesquisa Práxis Socioeducativa e Cultural da Universidade Federal do Tocantins, no decorrer do ano de 2024. Foram realizados oito encontros de forma híbrida, para que contemplassem a participação dos integrantes do interior do estado do Tocantins. Os textos discutidos suscitaram questões relevantes acerca de diversas temáticas, principalmente do cotidiano escolar, dos métodos pedagógicos e das políticas educacionais, resultando em novas propostas de pesquisa dos integrantes do grupo.
DANÇA NA UNIVERSIDADE: PRÁTICA EXTENSIONISTA NA FORMAÇÃO E INCLUSÃO DE PESSOAS IDOSAS
Authors: Santos de Oliveira Brito Marlon , Barbosa Osório Neila , Silva Neto Luiz Sinésio , Pereira Brito Oliveira Nubia
Published: January 2025

A pesquisa explora a dança como prática extensionista na formação de pessoas idosas no contexto da Educação de Jovens e Adultos. O objetivo é investigar como a dança pode ser utilizada como ferramenta educativa e valorizar trajetórias de vida e saberes. A metodologia é qualitativa, com observação participante dos pesquisadores. Os resultados são divididos em duas categorias: a dança como itinerário formativo para pessoas idosas, explorando seu potencial educativo e inclusivo; e o desenvolvimento de competências e habilidades na dança, alinhadas às diretrizes curriculares. Conclui-se que a prática observada é um exemplo de como a extensão universitária pode transformar a vida de pessoas idosas num caminho de retorno aos estudos de maneira integrada e inclusiva.
Efetividade da formação online de professores: um estudo no Programa de Formação em Tecnologias Digitais da Universidade Federal do Recôncavo da Bahia -UFRB
Authors: Almeida José Raimundo Paim de , Espirito Santo Eniel do
Published: January 2025

Com a chegada da pandemia de COVID-19, provocada pelo coronavírus SARS-CoV-2, a educação foi arremessada aos ambientes virtuais de aprendizagem e, dessa forma, exigindo das instituições de ensino e dos professores ações de formação para as tecnologias digitais compatíveis com o cenário apresentado, isto é, uma formação com efetividade imbricada com as Tecnologias Digitais da Informação e Comunicação (TDIC) e com os desafios de ensino totalmente online. Este estudo visa caracterizar a efetividade no trabalho docente das ações formativas promovidas no Programa de Extensão Formação em Tecnologias Digitais da UFRB, realizado online no início da pandemia de COVID-19. Trata-se de uma pesquisa com abordagem mista, isto é, qualitativa e quantitativa do tipo exploratória e descritiva, sendo caracterizado como um estudo transversal, com aplicação de questionário preenchido por 71 docentes participantes do programa formativo. Os resultados revelaram efetividade na formação docente após realização do(s)curso(s) do Programa de Extensão Formação em Tecnologias Digitais para Comunidade UFRB. Concluímos que houve um impacto significativo  no trabalho docente dos 71 professores respondentes em relação aos cursos ofertados pelo Programa, mas a Instituição precisa, com urgência, continuar e ampliar a oferta dos cursos para todos os professores, visto que eles já não são totalmente iniciantes no uso das tecnologias e, após vivenciado a implementação das tecnologias digitais no período pandêmico, apresentam outras necessidades específicas, como exemplo, maior domínio sobre avaliação da aprendizagem no ensino digital e uso de outras metodologias ativas. Destarte, percebemos a excelente receptividade dos cursos na formação dos docentes da UFRB no período inicial da pandemia de COVID-19, contudo, podem ser mais ampliados no sentido de promover uma educação crítica e emancipatória nos espaços digitais.
Optimizing Social Media Content Promotion for MSMEs Guided by Karang Taruna in Jayamukti Village
Authors: Akbar Taufik , Ikhsan M , Ermis Ismail Iklima
Published: January 2025

This community engagement initiative focuses on enhancing the promotional strategies of micro, small, and medium enterprises (MSMEs) associated with Karang Taruna in Jayamukti Village, aimed at bolstering their visibility and competitiveness in the digital market. Addressing the limited social media presence and promotional skills of these MSMEs, the program introduces targeted training on social media management, content creation, and audience engagement techniques. Using a structured method that combines workshops, hands-on assistance, and mentorship, participants develop skills in producing visually appealing and relevant content for platforms like Instagram and Facebook. Initial results indicate a significant improvement in participants' understanding and application of social media tools, setting a foundation for increased market reach and economic impact on the local community. Future stages of the program will focus on advanced analytics and sustainable promotion strategies, ensuring long-term benefits and self- sufficiency for the MSMEs involved.
Iodized salt has large impacts on child health and test scores in Ethiopia
Authors: Alemu Robel , Tafere Kibrom , Gashu Dawd , Joy Edward , Bailey Elizabeth , Lark Richard , Broadley Martin , Masters William
Published: January 2025

This study quantifies the impact of iodized salt on child survival and academic achievement based on sudden nationwide changes in access to iodized salt, given naturally occurring geographic variation in iodine. We combine data on birth timing and test scores on national school-leaving exams from 2003 to 2019 with child health surveys and newly collected measures of soil and grain iodine concentrations, finding that children with longer exposure to iodized salt in utero and infancy during the 1990s went on to have lower mortality and higher scores, especially in places with less iodine in locally grown food. Among children with the longest exposure, our main estimates show a national average test score gain of 0.09 standard deviations from widespread iodization, with an additional gain of 0.08 standard deviations for each standard deviation reduction in soil iodine. Placebo tests confirm that effects are specific to iodine (vs. selenium) and specific to cognition and survival (vs. height and weight, which are not affected by iodine deficiency). This provides the first large-scale evidence of how educational achievement is affected by national salt iodization programs recommended by the World Health Organization but not yet universally implemented.
WHEN TUBERCULOSIS IMITATES CANCER: UNRAVELING TUBERCULOUS PSEUDO-TUMOR IN GYNECOLOGICAL ONCOLOGY CASE REPORT
Authors:   Department of Gynecology and Obstetrics, Mohammed V Military Training Hospital, Rabat, Morocco., Khalid Guelzim , Abdelhamid Benlghazi ,   Department of Gynecology and Obstetrics, Mohammed V Military Training Hospital, Rabat, Morocco., Saad Benali ,   Department of Gynecology and Obstetrics, Mohammed V Military Training Hospital, Rabat, Morocco., Messaoudi Hamza ,   Department of Gynecology and Obstetrics, Mohammed V Military Training Hospital, Rabat, Morocco., Ait Bouhou Rachid ,   Department of Gynecology and Obstetrics, Mohammed V Military Training Hospital, Rabat, Morocco., Elmangoub Fatima ,   Department of Gynecology and Obstetrics, Mohammed V Military Training Hospital, Rabat, Morocco., Mehdi El Hassani Moulay ,   Department of Gynecology and Obstetrics, Mohammed V Military Training Hospital, Rabat, Morocco., Kouach Jaouad ,   Department of Gynecology and Obstetrics, Mohammed V Military Training Hospital, Rabat, Morocco.
Published: January 2025

Pelvic-peritoneal tuberculosis is a rare extrapulmonary form that can clinically and paraclinically resemble advanced ovarian cancer, potentially leading to unnecessary extensive abdominal and pelvic surgeries. We present the case of a 15-year-old Moroccan girl who exhibited abdominal distension and vague pain. Imaging studies showed bilateral ovarian masses and ascites, with a CA125 level of 500 U/ml, raising strong suspicion for ovarian malignancy. However, histological examination from a diagnostic laparotomy revealed numerous granulomas containing epithelioid and Langhans giant cells. The patient responded favorably to antituberculosis therapy, resulting in the normalization of her CA125 levels.
A Systematic Review of Gamified Interactive Systems for the Assessment of Mild Cognitive Impairment (Preprint)
Authors: Chen Yu , Gerling Kathrin , Verbert Katrien , Vanden Abeele Vero
Published: January 2025

BACKGROUND

Early assessment of mild cognitive impairment (MCI) in older adults is crucial, as it enables timely interventions and decision-making. In recent years, researchers have been exploring the potential of gamified interactive systems (GIS) to assess pathological cognitive decline. Yet, researchers are still investigating effective methods for system integration, designing GIS that are perceived as engaging whilst also improving the accuracy in assessing cognitive decline.

OBJECTIVE

This review aims to comprehensively investigate GIS used to assess MCI. Specifically, we reviewed the existing systems to understand the different game types (including genres and interaction paradigms) employed for assessment. Additionally, we examined the cognitive functions targeted. Finally, we investigated the evidence for the performance of assessing MCI through GIS by looking at the quality of validation for these systems in assessing MCI and the diagnostic performance reported.

METHODS

A systematic search was conducted in IEEE Xplore, ACM Digital Library, and Scopus to identify interactive gamified systems developed for assessing MCI. Game types were categorized according to genres and interaction paradigms. The cognitive functions targeted by the systems were compared with those assessed in the MoCA. Lastly, we examined the quality of validation on ground truth, relevance of controls, and sample size. The diagnostic performance on sensitivity, specificity, and AUC are reported.

RESULTS

A total of 81 papers covering 49 GIS were included in this review. The primary game types used for MCI assessment were classified as casual games (n = 30), simulation games (n = 17), full-body movement games (n=4), and dedicated interactive games (n = 3). Only six out of 49 systems assess cognitive functions comprehensively, compared to those functions assessed via the MoCA. The reported diagnostic performances of GIS were comparable to common screening instruments like MMSE and MoCA, with some systems reporting near-perfect performance (100% sensitivity and specificity).

CONCLUSIONS

This review provides a comprehensive summary of the literature on GIS for assessing MCI, explores the cognitive functions assessed by these systems, and evaluates their diagnostic performance. The results indicate that current GIS hold significant promise for the assessment of MCI, with several systems demonstrating diagnostic performance comparable to established screening tools. However, these systems' model training and validation exhibited significant deficiencies. Hence, despite some systems reporting impressive performance, there is a need for improvement in the validation studies, particularly concerning sample size and methodological rigor. Finally, we advocate for increased longitudinal research to enhance the reliability of these systems in evaluating MCI.
ANESTHETIC CONSIDERATIONS FOR CRITICALLY ILL PATIENTS WITH SEPSIS
Authors: SIROHI DIKSHA , KUMAR DINESH , CHOUDHARY RANU
Published: January 2025

Objective: Sepsis is a life-threatening condition characterized by organ dysfunction due to a dysregulated host response to infection. Critically ill patients with sepsis often require surgical interventions, presenting significant anesthetic challenges due to profound physiological alterations and multiple organ dysfunctions.
Methods: This systematic review aims to synthesize current evidence on anesthetic management strategies for critically ill patients with sepsis. A comprehensive literature search was conducted in PubMed, Embase, and Cochrane Library databases for studies published up to October 2023. Inclusion criteria encompassed clinical trials, observational studies, reviews, and guidelines focusing on anesthetic considerations in septic patients.
Results: Key findings indicate that thorough preoperative assessment, vigilant hemodynamic monitoring, careful selection of anesthetic agents, and tailored ventilatory strategies are crucial for improving perioperative outcomes. Hemodynamic instability necessitates the use of invasive monitoring and vasoactive medications like norepinephrine. Etomidate and ketamine are preferred induction agents due to their hemodynamic stability, with considerations for their side effects. Maintenance anesthesia often favors total intravenous techniques to minimize cardiovascular depression. Protective lung ventilation strategies are essential due to the high risk of acute respiratory distress syndrome (ARDS). Postoperative care requires multidisciplinary collaboration to manage ongoing sepsis and prevent complications.
Conclusion: This review highlights the importance of individualized anesthetic plans and suggests that adherence to evidence-based practices can enhance patient outcomes in this high-risk group.
COMPARISON OF CLONIDINE AND DEXMEDETOMIDINE AS ADJUVANTS TO LEVOBUPIVACAINE FOR SUPRACLAVICULAR BRACHIAL PLEXUS BLOCK IN UPPER LIMB SURGERY UNDER ULTRASOUND GUIDANCE
Authors: SINGHAL SWATI , VISHALI VENNAM NAGA LAKSHMI , SHARMA S. P.
Published: January 2025

Objective: The addition of adjuvants to local anesthetics can significantly improve the efficacy of regional blocks. This study compares the effectiveness of Clonidine and Dexmedetomidine as adjuvants to Levobupivacaine in a supraclavicular brachial plexus block for upper limb surgeries.
Methods: This observational comparative study included 68 patients, divided into two groups to receive either Dexmedetomidine or Clonidine with Levobupivacaine. The onset and duration of the sensory block and the time to first rescue analgesia were evaluated.
Results: Dexmedetomidine demonstrated a slightly faster onset and a significantly longer duration of sensory block and analgesia compared to Clonidine. Both drugs were well-tolerated without significant adverse effects.
Conclusion: Dexmedetomidine surpasses Clonidine in prolonging the effects of Levobupivacaine in supraclavicular brachial plexus blocks, suggesting its advantageous use in clinical settings for extended analgesia.
PREDICTING DIFFICULT INTUBATION IN ELECTIVE SURGICAL PATIENTS: THE ROLE OF BEDSIDE SONOGRAPHIC MEASUREMENTS
Authors: M. S. ASWIN , M. B. JAGADISH , MULAGUND SUMANGALA
Published: January 2025

Objective: Predicting difficult intubation remains a pivotal challenge in anesthesia, with traditional methods often failing to identify all at-risk patients. This study investigates the efficacy of bedside sonographic measurements as predictors of intubation difficulty in elective surgical patients.
Methods: A prospective observational study was conducted at Gulbarga Institute of Medical Sciences, Kalaburagi, involving 60 adult elective surgery patients. Sonographic measurements, including hyomental distance, pre-epiglottic space, anterior soft tissue distance, and neck circumference were evaluated for their ability to predict difficult intubation.
Results: The study found significant associations between all measured parameters and intubation difficulty. Specifically, shorter hyomental and pre-epiglottic spaces were strongly predictive of difficult intubations. Increased anterior soft tissue thickness and larger neck circumference were also linked to higher intubation difficulty.
Conclusion: Bedside sonographic measurements provide a reliable method for predicting difficult intubations in elective surgical patients. Their integration into preoperative evaluations can significantly enhance the prediction and management of difficult airways.
PRIMARY NEUROENDOCRINE TUMOR OF THE ENDOMETRIUM, A RARE TUMOR: CASE SERIES
Authors: TIWARI PRATEEK , PATIDAR SHREENA , PAL V.
Published: January 2025

Objective: Endometrial NET is a rare disease with a poor prognosis. Due to its rarity, there are no evidence-based standards or international guidelines for the diagnosis and treatment of endometrial NETs.
Methods: In this study, we present our experience with four cases of NETs of the endometrium to describe these rare tumors’ clinical characteristics and behaviour. The clinicopathological characteristics, treatment and prognosis, were analysed.
Results: Most common age group for presentation was 50 to 70 y. Irregular vaginal bleeding was most common symptom at presentation. Three patients underwent surgery followed by adjuvant chemoradiation while one patient with metastatic disease underwent chemotherapy. Overall prognosis was poor with two patients died 12 mo and 24 mo, respectively. One patient was lost to follow-up after 39 mo and one patient was disease free till last follow-up.
Conclusion: Given the aggressive nature of the disease, patients should be carefully observed and followed up regularly. More studies with a higher number of cases are required to establish a standard therapeutic protocol.
A CLINICAL COMPARATIVE STUDY OF RENAL PARAMETERS OF OBESE AND HYPERTENSIVE PATIENTS WITH NON-OBESE HYPERTENSIVE PATIENTS
Authors: VANAJA KALAPALA , LAVANYA Y. RUTH , LATHA J. MADHAVI
Published: January 2025

Objective: Obesity is associated with an early onset of glomerulomegaly, hemodynamic changes of a hyper-filtering kidney, and increased albuminuria. It is an important risk factor for incident CKD and increase risk of ESRD. The aim of the present study is to compare the influence of renal parameters among the obese and non-obese hypertensive patients attended to a tertiary care hospital.
Methods: The study was conducted on 120 patients who were divided into 4 groups Group ‘O’ comprises of obese individuals; Group ‘OH’, which comprises of 30 obese and hypertensive individuals; Group ‘NO, H’ which comprises of non-obese and hypertensive individuals and Group ‘C’ which comprises of 30 healthy control group having normal BMI.
Results: The mean±SD of serum creatinine was 0.88±0.06; 1.13±0.1; 0.7±0.08; 0.7±0.06 of all the 4 groups and the Serum urea mean±SD was 26.4±3.8; 36.6±5.42; 21.2±3.2; 20.4±3.2 and the Serum uric acid mean±SD levels were 4.3±0.64; 4.3±0.56; 3.8±0.3; 3.7±0.26 of all the 4 groups and eGFR values were 139.5±1.8; 95.3±23.20; 116.2±7.4;118.6±6.2 in obese, obese hypertensive, non-obese hypertensive and control subjects respectively. The results showed that there was a significant influence of renal parameters among the four tested groups.
Conclusion: The strategies to prevent weight gain and to induce weight loss in patients who are already obese would ultimately reduce the incidence of obesity-mediated renal disease.
A FLEETING DARKNESS: TRANSIENT VISION LOSS IN PSEUDOTUMOR CEREBRI A CASE REPORT
Authors: RATHWA SANJAYKUMAR , RATHWA PRATIKSHA , KARPATIYA MAULIKKUMAR
Published: January 2025

The hallmark of pseudotumor cerebri is a neurological condition marked by high intracranial pressure (ICP) without any discernible localizing signs or neurological impairments with normal intracranial structures. Radiographic exclusion of an intracranial mass is necessary for the mainly clinical diagnosis. We reported a case of a 27-year-old lady presented to the department of general medicine with severe headache and bilateral blurring of vision. Ophthalmoscopy revealed bilateral papilledema. Magnetic resonance imaging (MRI) brain with orbit revealed typical alterations, including bilateral flattening of the posterior sclera and protrusion of the optic nerve heads. Above findings were suggestive of pseudotumor cerebri. Treatment designed to reduce discomfort while preserving vision. Initial treatment included methylprednisolone, mannitol and acetazolamide. Acetazolamide and oral Prednisolone were administered after discharge in a tapering dose over a period of 1 mo.
Building a Blockchain-Based Messaging Application on Ethereum
Authors: B K Hanumantha
Published: January 2025

Decentralized application make use of peer-to-peer networks, this ensures that no network failure can occur due to
central node failure. Blockchain serves as an immutable ledger which allows messaging to take place in a decentralized manner.
A decentralized application for communication and resource sharing is need in today’s world, where keeping data on a centralized
server can be risky and costly experience. With the help of various consensus, we can implement different ways to share
resources and communicate. Together with Blockchain and Decentralized Applications, we can create a secure and reliable
messaging application that overcomes the drawbacks of traditional messaging applications.
Reconceptualizing The Dispute Resolution Model for Village Head Elections Towards Independent and Fair Elections
Authors: Zainudin Arif , Safa’at Muchamad Ali , Anshari Tunggul , Susmayanti Riana
Published: January 2025

This study aims to reconceptualize the dispute resolution model for Pilkades, which has traditionally been handled by regents/mayors (Bupati/Walikota), a mechanism criticized for being prone to political interference and lacking principles of justice and independence. The election of village heads (Pilkades) represents a form of local democracy, reflecting community participation in village governance. However, its implementation is often marred by disputes over election results, leading to social tensions and conflicts. Using normative and empirical legal approaches, this research analyzes the weaknesses in the existing dispute resolution procedures and proposes an alternative model that is fairer and more transparent. The findings reveal that entrusting dispute resolution authority to regents/mayors poses significant challenges, such as political bias, unclear legal mechanisms, and insufficient community involvement. Therefore, an independent and neutral institution is required to handle Pilkades disputes by emphasizing the principles of justice and transparency. This study recommends the establishment of a special body through regional regulations to manage dispute resolution independently, involving community elements and utilizing digital technology to enhance process transparency. By reconstructing the Pilkades dispute resolution model based on the principles of justice, transparency, and independence, this approach is expected to strengthen village democracy and prevent prolonged conflicts.
Kolaborasi Antara Ekonomi Hijau dan Ekonomi Islam dalam Mencapai Kesejahteraan Sosial dan Lingkungan: Analisis Terhadap Strategi Pembangunan Berkelanjutan Society 5.0
Authors: Permana Ngadi , Eka Wahyu
Published: January 2025

This study aims to analyze the collaboration between green economy and Islamic economy in achieving social and environmental welfare through sustainable development strategies within the context of Society 5.0. The green economy, which emphasizes sustainable management of natural resources and environmental friendliness, can strengthen the principles of Islamic economy focused on social justice, environmental balance, and equitable wealth distribution. The integration of these two concepts is expected to create an inclusive and sustainable economic system that supports the achievement of Sustainable Development Goals (SDGs). However, its implementation requires policies that accommodate the social, cultural, and political conditions of each country. This study concludes that the collaboration between green economy and Islamic economy offers great potential for creating holistic social and environmental welfare in the Society 5.0 era
Analisis Pengaruh Indikator Brand Resonance Terhadap Brand Loyalty Pada Konsumen Restoran Berlabel Halal di Solo Raya
Authors: Delfiya Anggraini  , Moechammad Nasir
Published: January 2025

This study aims to examine (1) the effect of brand credibility, (2) the effect of service quality, (3) the effect of customer satisfaction, and (4) the effect of brand association on brand loyalty among users of halal-certified restaurants in Solo Raya. This research employs a quantitative approach. The population of this study includes individuals who visit halal-certified restaurants in the Solo Raya area. Sampling was conducted using a non-probability sampling method, with a total sample size of 200 respondents. The study uses primary data collected through the distribution of questionnaires. The data analysis methods employed in this research include validity tests, reliability tests, multiple linear regression analysis, F-tests, t-tests, and the coefficient of determination (R²). The results of the study indicate that the variables brand credibility, service quality, customer satisfaction, and brand association collectively explain brand loyalty by 21.6%, while the remaining 78.4% is explained by other variables not examined in this study. Based on the findings, it was concluded that (1) brand credibility has a positive and significant influence on brand loyalty, (2) service quality has a positive and significant influence on brand loyalty, (3) customer satisfaction has a positive and significant influence on brand loyalty, and (4) brand association has a positive and significant influence on brand loyalty.
Conceptual design of control system for component sorting
Authors: Postrygan Oleksandr
Published: January 2025

This article deals with the conceptual design of the control system for a line intended for sorting products. It is an automated workplace with sensor differentiation of products and subsequent separation. The preliminary arrangement of the workplace and the placement of sensors and actuators is proposed. Control networks for the control system in the form of block diagrams are also proposed.
Wheeled robot for rough terrain
Authors: Uljan Branislav , Kelemen Michal
Published: January 2025

The article deals with the design of a robot chassis intended for movement on uneven terrain. The chassis is composed of a front part with two parallel arranged wheels and two tiltable parts with serially placed wheels. This concept adapts to uneven ground surfaces.
Universal tester of length sensors
Authors: Palova Katarina , Kelemenova Tatiana
Published: January 2025

The article deals with the design of a universal tester of length and position sensors. It is composed of a rotary table and a sliding mechanism for generating displacement. Length parallel gauges are used as standards. The result of the testing is the static and calibration characteristics of the sensor and the verification of the maximum permissible errors of the sensor and measuring chain.
Educational procedures for training students in the field of pneumatic systems
Authors: Tuleja Peter
Published: January 2025

The aim of this article is to present an educational model of the process of teaching students in subjects focused on the use of compressed air in automated industrial operations. The starting point is the existing commercially available training platform kit, the use of which provided the basis for developing the student training model described in the article.
The article further discusses the training needs in all methods of controlling pneumatic circuits and focuses on the possibility of building an independent training workplace based on the electropneumatic base of the components used. The article describes several stages of the constantly improved educational platform, also with the contribution of student involvement in this activity. The conclusions of the article offer further guidance in the gradual completion of the educational model focused mainly on the practical training of graduates resulting in the ability to respond to market challenges after completing their university studies at our faculty.