bluuebunny/crossref_metadata_2025 huggingface dataset:
EDUCATION AS A TOOL TO IMPROVE THE COMPETITIVENESS OF THE ECONOMY
Authors: Voronina O. , Moskvina A. , Yarmak O.
Published: June 2022

The article considers the interaction of education and all spheres of public life. It is shown that education has lost its natural role and is used as a tool of society management. Ideological government is implementing the concept developed in favor of the powerful, using information flows in which education is of paramount importance. Organized in this way, the education system is an important element of manipulation technologies, so that society is programmed to certain actions to maintain the established order. The article reveals that the degree of influence on human consciousness depends on the level of human education.
The degradation of education covers the whole world. This requires rethinking the meaning and essence of education, returning it to its former natural functions. The article shows that the formation of an adequate education system is possible only if it is reformed and attracts investment in this strategically important sector, which can raise the economy to a much higher level of development and competitiveness.
Only the sphere of the mind can indicate the way out of this situation. The article proposes ways of reforming education by existing forces and knowledge, counteraction at the level of ideas and meanings.
In the formation of a new education system it is proposed: to increase the availability of quality education; reorientation to human training in rapidly changing conditions with intensive development of social and economic processes; preserving the fundamentals of education in becoming a mature, socially responsible citizen; introduction of continuing education with competencies, methodology and culture of independent cognition, self-development, the desire to increase individual potential through the acquisition of new knowledge and skills; ensuring the advanced nature of the development of education, its focus on the demands and values of future civilization, which will meet its true essential functions. This will help society to resist manipulation, create positive useful ideas, knowledge, innovations and inventions, strengthen the sovereignty of countries, their positions on the world stage and increase the competitiveness of their economies.
ASSESSMENT OF FINANCIAL CAPACITY OF TERRITORIAL COMMUNITIES
Authors: Taukesheva T. , Daudova G. , Prasol V.
Published: June 2022

Considered structural sectoral reforms taking place in Ukraine in the process of decentralization are aimed at forming viable territorial communities that are able to solve social problems to meet the needs of residents of administrative-territorial units, taking into account socio-economic, environmental, geographical, cultural, historical and other factors of their development.
At the same time, the issues of obtaining financial results from the introduction of tax and budget decentralization, budget financing of expenditures guaranteed by the state remain relevant. Assessment of indicators in these areas will allow to determine the level of financial potential and risks for the functioning and development of spheres of life of local governments.
The outlined indicators of assessing the financial capacity of local budgets are based on the analysis of budget indicators of territorial communities and aim to identify problematic issues that hinder the socio-economic development of administrative territories and the inability of local authorities to perform their own and delegated powers.
Among the factors influencing the indicators of indicators of local government solvency assessment, the system of horizontal budget equalization and the methodology for determining the local budget tax capacity index need to be improved.
Standardization of indicators for assessing the financial capacity of local communities will increase the effectiveness of existing methodologies for measuring them.
The updated mechanism for assessing the financial autonomy and independence of local budgets is based on a deeper analysis of financial indicators of local budgets, which requires further study.
STATE SYSTEM OF HOSPITALITY AND TOURISM SUPPORT IN THE CRISIS
Authors: Khudaverdiyeva V.
Published: June 2022

The urgency of this problem, its practical significance determined the choice of research topic and served as a basis for formulating its goals and objectives. The purpose of research work is to conduct a comprehensive analysis of measures to support tourism in modern conditions in the context of world and domestic experience. Achieving this goal requires the solution of the following tasks: to assess the main problem areas of tourism in a crisis; to systematize the world and domestic experience of supporting the sphere of tourism in the current conditions; assess possible scenarios for the recovery of tourism, taking into account the measures taken and current trends.
The article identifies the importance of hospitality and tourism, which is a vital source of income from tourism and foreign direct investment, as well as jobs, especially for women and youth. The closure in March 2019 of the boundaries of external and internal, not only the revenues of tourism companies to zero, but also led in some cases to significant losses. Many companies in the country are facing the threat of bankruptcy of hotels, transport, as well as services, excursions and consulting services in the field of tourism. The following technical assistance activities in the field of institutional strengthening and resilience need to be identified that can help Member States to guide and support recovery processes from the negative effects of COVID-19, in particular to support job retention in the tourism sector: adaptations during COVID-19; public-private partnership to improve tourism; development of communication strategy for crisis response; media trainings for enterprises serving the tourism sector; capacity building programs in the field of tourism development and management in order to accelerate recovery; strategy of national development of human capital in the field of tourism; development and strengthening of target management organizations; strengthening the potential of domestic tourism, development and promotion of local tourism products; - realization of women's rights and material opportunities through tourism; youth employment project in the field of tourism; introduction of information and communication and technical innovations.
The Appearance of Prefabrication as a Subject in Architectural Education at the Budapest Technical University
Authors: Karácsony Rita , Vukoszávlyev Zorán
Published: June 2022

The building economics demands after World War II required creative and imaginative engineering work from the actors of the construction industry. For the participants of the process, factory prefabrication and on-site installation presented the possibility of applying reinforced concrete structures economically. These structures had already been present in the modern engineering mindset for decades in the interwar period.From 1949 onwards, centralised state control developed in Hungary, and the new economic policy also expressed a methodological change in education. An essential background of this practice was the training of architects at the Budapest Technical University, in accordance with the new needs of the construction industry. What effect did the development, dictated by the state, have on the evolution of the Hungarian construction industry, and what advances did it highlight compared to the innovations between the two world wars?The study explores connections and correlations between theoretical knowledge and practical experience at the time and examines the transformation of architectural education through an objective analysis of documents. In addition to the exploratory research of archival materials, we place particular emphasis on the exploration of personally experiential processes by including an accurate picture of contemporary developments through oral history. With the scientifically evaluated data, the study is the first to examine the characteristics of Hungarian engineering education of the period introducing the most innovative designers of the Hungarian construction industry to transfer practical living knowledge at the university level.
Pandemic challenges vs. public policy: reflections on the electoral administration in the world's largest democracy
Authors: Beulah C Hepzibah
Published: June 2022

Democratic elections pose an immense challenge to any government during an emergency crisis like the COVID-19 pandemic. More so for a country like India, with close to 18% of the world's population comprising an equally daunting and eager voter base of around 911 million in the time of a raging virus, both in the urban and rural areas of the nation. The first democratic large-scale election during the pandemic was successfully held in the state of Bihar in North India with more than 90 million voters, which was an astonishing feat by itself. The model followed by South Korea with the highest voter turnout provided an insight to the Indian authorities on conducting the elections. The Indian Election Commission, an independent statutory body which is entrusted with the task of conducting free and fair elections, allowed for the virtual mode of campaigning, and specific guidelines for polling were recommended. The rule changes have profound implications in significantly reducing crowded campaigns, which was synonymous with Indian democracy. The traditional lens through which the administration of elections was perceived has undergone a paradigm shift during the pandemic. New insights might surface if the electoral administration is reviewed in this study on an argumentative basis against the background of the big steps taken by the Indian election machinery. The aspects on which the research debates include: (i) the pros and cons of the action taken by the regulators; (ii) positive and negative responses from the political parties; and (iii) health and safety of the voters. The study concludes by affirming with data on the success of the Bihar Election and the wise choice of the Indian government in seizing the opportunity by taking the cues from South Korea.
Wybory parlamentarne we Wspólnotach Autonomicznych Galicja i Kraj Basków w czasie pandemii wirusa SARS-CoV-2
Authors: Salamon Justyna
Published: June 2022

Zakres przedmiotowy artykułu obejmuje analizę przebiegu i rezultatów wyborów do parlamentu we Wspólnotach Autonomicznych Galicji oraz Kraju Basków, które odbyły się 12 lipca 2020 r. W Galicji jako pierwszej ze Wspólnot Autonomicznych rząd hiszpański wprowadził ostatnią fazę ograniczeń związaną z najłagodniejszymi obostrzeniami w czasie pandemii koronawirusa, tzw. nueva normalidad (obowiązywała od 15 czerwca 2020 r.). Oznaczało to, że wybory w Galicji przeprowadzono w czasie obowiązywania strefy 3 (tzw. zielonej, od 8 czerwca 2020 r.), w której wprowadzono najniższy stopnień ograniczeń. Z kolei w Kraju Basków pierwotnie wybory zaplanowano na 5 kwietnia 2020 r. Z powodu obowiązywania od marca 2020 r. estado de alarma (stanu alarmu) wybory zostały przełożone w obu tych Wspólnotach Autonomicznych. W trakcie analizy zwrócono również uwagę na frekwencję wyborczą oraz na rozłożenie głosów oddanych na poszczególne partie polityczne.
Analyzed of Fixed Asset Management Based on Effectiveness and Efficiency at Office of Subdistrict Head Binjai
Authors: Catherine Evalina Tarigan  , Junawan  , Rahima Purba
Published: June 2022

This paper aims described analyzing the effectiveness and efficiency of fixed asset management at the Binjai District Office, Langkat Regency. This research is qualitative research with a descriptive approach. Data collection techniques in this study were the observation of the work of employees who handle fixed assets, interviews with employees who handle fixed assets, and documentation of documents related to fixed assets at the Binjai District Office of Langkat Regency. Based on the results of the research that has been carried out, it shows that: the results of the analysis of the effectiveness of fixed asset management at the Binjai District Office of Langkat Regency have not been effective as seen from the incompatibility of timeliness, the accuracy of cost calculations against applicable regulations.
Estrés postraumático, síndrome de la cabaña, Covid 19 y psicología positiva: Caso práctico
Authors: Chagñay Lema Graciela , Córdova Suárez Manolo Alexander
Published: June 2022

Introducción. En la pandemia del COVID-19, las personas han experimentado el encierro luego de haber vivido durante mucho tiempo la cuarentena y el teletrabajo se refleja la necesidad urgente de abandonar el domicilio y volver a la realidad, pero el miedo al contagio puede más, uno de las consecuencias es el estrés postraumático. Objetivo. La investigación es determinar los niveles de presencia del Síndrome de la Cabaña en los trabajadores del Gad Provincial de Zamora Metodología. Se realizó mediante un estudio transversal aplicado a 373 funcionarios en nómina, se estableció una muestra determinada con el calculador muestral surveymonkey con un valor de 189 trabajadores. Se evaluaron variables sociodemográficas de los trabajadores. Se aplicó el test del Síndrome de la Cabaña para medir los niveles de los trabajadores por confinamiento y Covid 19. Resultados. Los resultados del estudio muestran la presencia de 64 % del síndrome con temor a volver a salir de casa y volver a una nueva realidad.  Conclusión. De lo detectado se concluye que uno de los efectos psicológicos es el estrés Postraumático por haber perdido a un amigo, familiar, conocido necesita de primeros auxilios psicológicos ser escuchado o derivado a un especialista. Para disminuir el nivel medio encontrado se recomienda paulatinamente ir saliendo de casa cómo una rutina progresiva de romper este miedo al contagio del virus.
HUBUNGAN PENGETAHUAN DAN SIKAP IBU DENGAN PENANGANAN ISPA DI RUMAH PADA BALITA DI PUKESMAS TUMBUAN
Authors: Pawiliyah Pawiliyah , Triana Neni , Romita Dora
Published: June 2022

Kejadian ISPA erat terkait dengan pengetahuan dan sikap orang tua terhadap penanganan ISPA, karena orang tua sebagai penanggung jawab utama dalam pemeliharaan kesejahteraan anak. Penelitian ini bermaksud untuk mengetahui Hubungan Pengetahuan Dan Sikap Ibu Dengan Penanganan ISPA Di Rumah Pada Balita Di Puskesmas Tumbuan tahun 2018. Penelitian ini menggunakan metode accidental sampling dengan penekatan cross sectional menggunakan kuesioner sebagai alat pengumpulan data dengan menggunakan uji statistik yaitu chi square. Besaran sampel sebanyak 41 responden yang terdiri dari ibu yang balitanya menderita ISPA yang di bawah berobat di Puskesmas Tumbuan tahun 2018. Hasil penelitian berdasarkan uji statistik Pearson chi-square didapatkan nilai (P = 0,007<0,05) maka dapat disimpulkan bahwa ada hubungan pengetahuan ibu dengan penanganan ISPA di rumah pada balita. Untuk sikap dengan penanganan ISPA pada balita di rumah, dimana nilai p value 0,014 < Alpha 0,05 berarti signifikan. Jadi Ada hubungan Sikap ibu dengan penanganan ISPA di rumah pada balita di Puskesmas Tumbuan. Kata Kunci: Pengetahuan, sikap, penanganan ISPA, Ibu balita, di rumah  ABSTRACT The incidence of acute respiratory infections is closely related to the knowledge and attitudes of parents towards the handling of acute respiratory infections, because parents are the main responsibility in maintaining children's welfare. This study intends to determine the relationship between knowledge and attitude of mothers with the handling of acute respiratory infections at home in toddlers at health center in 2018. This study uses accidental sampling method with a cross sectional approach using a questionnaire as a means of data collection using statistical tests, namely chi squares. The sample size of 41 respondents consisting of mot] hers whose babies suffered from ARI under treatment at the Tumbuan Health Center in 2018. The results of the study based on Pearson chi-square statistical tests obtained values (P = 0.007 <0.05) it can be concluded that there is a relationship of maternal knowledge with ARI handling at home in infants. For attitudes with ARI handling in infants at home, where the p value is 0.014 <Alpha 0.05 means significant. So there is a relationship between the attitude of the mother and the handling of ARI at home in children under five at the Tumbuan Health Center. Keywords: Knowledge, attitude, handling ARI, mother under five, at home
RELATIONSHIP OF HEALTH PROMOTION WITH THE UBERCULOSIS DISEASE AT BASUKI RAHMAT PUBLIC HEALTH CENTER BENGKULU CITY
Authors: Yenni Fusfitasari Yenni Fusfitasari
Published: June 2022

The discovery of TB patients is done passively with active promotion. Screening of suspect patients is carried out in health care units supported by active counseling, both by health workers and the community to increase the coverage of TB suspect suspect discovery. The problem in this study is the increased incidence of pulmonary TB disease. The purpose of this research is to know the relationship between health promotion and tuberculosis in Basuki Rahmat Public Health Center Bengkulu City. This type of research is cross sectional study. The population was 19,220 people and the study sample was 99 people. The type of data used in research is to use primary and secondary data. Data analysis in this study used univariate and bivariate data analysis with the statistical method of chi square test at a significance level of 0.05. The results of this study were the majority of respondents (55.6%) who lacked health promotion at the Basuki Rahmat Public Health Center in Bengkulu City. Nearly some respondents (46.5%) who experienced tuberculosis at the Basuki Rahmat Public Health Center in Bengkulu City. There is a relationship between health promotion and tuberculosis in Basuki Rahmat Public Health Center Bengkulu City. For Basuki Rahmat Community Health Center staff, it is necessary to carry out regular monitoring and evaluation and to visit the homes of patients with pulmonary TB in order to improve the knowledge and attitudes of patients with pulmonary TB so that it is expected that patient compliance in pulmonary TB increases.
Análise de Solo misturado com Resíduos de Construção e Demolição (RCD) para uso em Obras Rodoviárias
Authors: Pereira Letícia Azevedo de Farias , Amorim Ênio Fernandes , Motta Laura Maria Goretti da
Published: June 2022

A indústria da construção civil é responsável por um consumo de 20 a 50% dos recursos naturais existentes no planeta. Uma maneira de mitigar a exploração de jazidas de extração de agregados naturais e ampliar a utilização de resíduos são os estudos da aplicação destes na pavimentação.O presente estudo analisou tecnicamente o potencial de aplicação dos resíduos de construção e demolição de obras (RCD) em misturas com solo areno-siltoso como uma possibilidade de reúso eficiente em camada de base de pavimentos. Tendo em vista as diretrizes do novo método de dimensionamento de pavimentos flexíveis do Departamento Nacional de Infraestrutura de Transportes (DNIT) analisar o desempenho mecânico de RCD em misturas com solo pelo módulo de resiliência (MR) e deformação permanente (DP) para verificar a viabilidade do emprego destes materiais nas camadas dos pavimentos é de fundamental importância. Desse modo, foram realizados ensaios triaxiais de carga repetida para determinação do módulo de resiliência de misturas de solo-brita e solo-RCD em várias proporções e posteriormente realizou-se o dimensionamento de uma estrutura de pavimento utilizando o software MeDiNa para verificar se misturas de solo com os agregados de RCD proporcionariam camadas estruturais de base com desempenho comparável ao de solo-brita. A partir da magnitude do módulo de resiliência das misturas e dos dimensionamentos verificou-se a potencialidade de emprego da mistura de solo com os resíduos locais na estrutura de pavimento com características de projeto e espessuras específicas. O dimensionamento utilizando o software MeDiNa comprovou a possibilidade da utilização da mistura de solo-RCD 70-30 em camada de base de forma adequada.
Molluscicidal activity of extracts of plants from the Cerrado against Biomphalaria glabrata (Say, 1818)
Authors: Cruz Juliana Pimenta , Ribeiro Fábio , Vasconcelos Viviane de Oliveira
Published: June 2022

Plant-derived molluscicides have been indicated as selective and low-cost strategies for the control of Biomphalaria glabrata (Say, 1818), an intermediate host of schistosomes. This study aimed to evaluate the aqueous and ethanolic extracts of leaves of plants present in the Cerrado such as Caryocar brasiliense Camb., Ximenia americana L., Piptadenia viridiflora (Kunth) Benth., and Schinopsis brasiliensis Engl. as alternatives in the control of the mollusk B. glabrata. For this, leaves were collected from plants at the in Montes Claros-MG. Extracts at concentrations of 150, 100, 75, 50, and 25 μg/mL, a positive control containing niclosamide at 3 μg/mL, and a negative control containing dechlorinated water were used to verify the molluscicidal activity. To evaluate toxicity to non-target organisms, Artemia salina was treated with extract concentrations of 10, 100, and 1000 μg/mL. The tested aqueous and ethanolic extracts showed significant mortality within 24 h of exposure. At concentrations above 75 μg/mL, the aqueous extracts of P. viridiflora, C. brasiliense, and S. brasiliensis achieved mortality higher than 90%. Regarding ethanolic extracts, mortality above 80% was observed for all tested plants at concentrations above 50 μg/mL. No toxicity was observed against A. salina. Thus, high molluscicidal activity of ethanolic and aqueous extracts of the tested plants against adult B. glabrata was observed and no toxicity was observed against A. salina.
Percepção da inserção dos acadêmicos do internato do curso de Medicina da USCS no serviço de obstetrícia do município de São Caetano do Sul
Authors: Grespan Regina Maura Zetone , Bizário João Carlos da Silva
Published: June 2022

Introdução: Modificações ocorreram no Serviço de Obstetrícia do Hospital Euryclides de Jesus Zerbini, em São Caetano do Sul, decorrentes à inserção dos acadêmicos do internato do Curso de Medicina da Universidade Municipal de São Caetano do Sul, alterando a rotina da equipe de saúde, gerando a necessidade de identificar problemas e soluções. Objetivo: Analisar a percepção dos atores sobre a inserção dos internos do Curso de Medicina, nos processos de atendimento no Hospital. Método: Estudo qualitativo, mediante técnica de grupo, utilizando-se amostra por conveniência de acadêmicos do 9º semestre, pacientes/familiares atendidos pelos alunos, equipe em contato com os alunos e médicos/preceptores/docentes do curso, totalizando 4 grupos. Resultado: Observou-se despreparo na recepção dos alunos, na identificação e apresentação à equipe, aos pacientes/familiares, e também um déficit na integração com a equipe e serviço. Os preceptores não foram capacitados a realizar a preceptoria. Houve desconforto da equipe pela presença dos internos; estranhamento dos pacientes por desconhecimento da característica acadêmica do hospital; despreparo dos preceptores para acolher e orientá-los e sensação de falta de pertencimento dos internos no serviço por falta de integração. Conclusão: A desestruturação das atividades de prática em serviço no estudo pode prejudicar na formação, na qualidade do atendimento e no clima organizacional. Os achados fomentam a revisão dos processos de integração entre universidade e serviço estudado, colaboradores, usuários e alunos, bem como o desenvolvimento de estratégias de capacitação dos preceptores pela universidade para o aperfeiçoamento do ensino e prática em serviço aos alunos do curso de graduação da universidade.
Growth of Anagnostidinema amphibium LBABL-2 (Oscillatoriales, Cyanobacteria) in Different Abiotic stress conditions
Authors: Machado Calandrini Gabriel San , Gomes Aline Lemos , Cunha Celly Jenniffer da Silva , Pires Paola Vitória Brito , Pinheiro Samara Cristina Campelo , Tavares Vanessa Bandeira da Costa , Sousa Eliane Brabo de
Published: June 2022

The Bolonha reservoir (Belém, Pará) is eutrophicated and dominated by aquatic macrophytes that are often removed and deposited on the banks of the environment, suffering decomposition. Some microorganisms that live associated with macrophytes return to the environment through leaching, among them cyanobacteria. The objective of the study was to evaluate the growth of the species Anagnostidinema amphibium LBABL-2, in microcosm, by three experiments under different environmental conditions and nutritional stress simulating its growth during the cleaning process of the Bolonha reservoir. Growth was determined by optical density and chlorophyll-a. The species formed a slime mat composed of tangles of green, not capitate, not constricted, not attenuated, slightly curved trichomes 600 μm long, composed of cells that measured, on average, 4.1 μm -2.2 μm in length and width, respectively, and showed cyanophycin granules in the cell wall between two cells. The absence of nutrients was the main stressor of Anagnostidinema amphibium LBABL-2, which showed higher growth in the roots of macrophytes immersed in the reservoir, but low growth in the absence of nutrients. The study will support actions for the management of aquatic macrophytes in the reservoir with emphasis on stressors and growth promoters of cyanobacteria associated with their roots.
Resposta da alface à aplicação de doses, de biofertilizante e lâminas de irrigação
Authors: Leite Kelly Nascimento , Oliveira Querolaine Sampaio , Marques Kecy Dhones Monteiro , Oliveira Júnior Porfirio Ponciano de , Sousa Geocleber Gomes de , José Jefferson Vieira
Published: June 2022

A alface é uma cultura cultivada amplamente em todo pais, são sensíveis ao estresse hídrico, todavia são beneficiadas pelo emprego de adubos orgânicos. O objetivo desse trabalho foi avaliar o crescimento, desenvolvimento e produtividade da alface sob efeito de quatro doses de biofertilizante de origem bovina e diferentes lâminas de irrigação. Testaram-se quatro doses de biofertilizante 10, 20, 40 e 60 m³ha-1, e quatro lâminas de irrigação, 100, 90, 80 e 70% das necessidades hídricas da planta. As variáveis analisadas foram, número de folhas, diâmetro da copa, crescimento radicular, massa fresca da parte aérea, massa seca da parte aérea e massa seca da raiz. As melhores variáveis foram alcançadas com as maiores doses de biofertilizante acima de 20 m3ha-1. As lâminas de irrigação também tiveram influência positiva no desenvolvimento da cultura, a que melhor influenciou no desenvolvimento da alface foi a lâmina de 126 mm, correspondente a 90% das necessidades hídricas calculadas, assim a lâmina de 100% pode causar decréscimo no crescimento, por excesso de água. Portanto o uso do biofertilizante é uma alternativa viável, podendo aumentar a produtividade e afetar de maneira positiva as variáveis qualitativas da alface.
A interface entre a formação continuada do professor e a inclusão do aluno com necessidades educativas especiais
Authors: Barro Andre Gama , Silva Junior Washington Luiz Pedrosa da
Published: June 2022

O movimento em prol de um trabalho que atenda às necessidades, junto aos alunos portadores de auxílio educativo especial vem se intensificando na última década, baseado na premissa de que, a independência pode contribuir para a socialização dos alunos que precisam ter a chance de se desenvolver social e intelectualmente. Nesse sentido, o presente estudo tem como objetivo apresentar aspectos relacionados a formação continuada de professores no que cerne a inclusão do aluno com Necessidades Educativa Especiais-NEE. Nessa perspectiva, para que tenhamos uma revisão sistemática da literatura optamos por fazer um estudo bibliográfico, sistemático. Desse modo, buscamos por uma revisão de literária que permeie todo o processo de análise de dados de nosso estudo. Os resultados obtidos mostram que a formação continuada vem sendo apontada como vetor de profissionalização capaz não só de incorporar dispositivos concretos de criatividade, responsabilidade, confiança e avaliação construtiva, mas também de colocar o professor e o seu trabalho no centro das atenções frente a desafios que permeiam a Educação Inclusiva. Ademais, a formação continuada na inclusão do aluno com NEE, busca por conhecimento e aperfeiçoamento que possibilite ao professor ordenamento das metodologias de ensino, que se apresentem como subsídios para uma ação humanizada.
Recursos Educacionais Abertos para ensino de saúde e sexualidade na disciplina de ciências do 9º ano do fundamental II
Authors: Almeida Luiz Fernando Correia de , Sousa Jean Carlos Matos de
Published: June 2022

O uso de Recursos Educacionais Abertos (REAs) para ensino de saúde e sexualidade na disciplina de ciências do ensino fundamental II. O presente trabalho traz de forma sucinta a fundamentaçao teórica sobre movimento de acesso aberto, ciência aberta aliada às tecnologias da informação e comunicação, o trabalho avança especialmente sobre educação aberta e recursos educacionais abertos e a potencialidade de seu uso no processo de ensino e aprendizagem no ambito escolar. A metodologia contou com pesquisa bibliografica, que foram realizadas leituras para compreensão da tematica. Os resultados que podemos observar é que os repositorios que tratam sobre disciplinas gerais e que sobre o tema específico sobre saude e sexualidade foi possível mapear apenas a iniciativa da FIOCRUZ atraves do repositório EDUCARE. A pesquisa nessecita de maiores estudos para compreender como os REAs podem contribuir de forma mais horizontal o ensino de ciências.
Consequências da suplementação alimentar com whey protein para praticantes de exercícios físicos: uma revisão integrativa
Authors: Silva Paulo Oliveira , Silva Vinicius Jailson , Vasconcelos Tibério Cesar Lima de
Published: June 2022

Os suplementos alimentares são conceituados com substâncias adicionadas à dieta, com o objetivo de complementar, suprir carências nutricionais ou ainda para melhorar o desempenho físico. O whey protein é o termo popular para o suplemento alimentar a base de proteínas do soro do leite. O objetivo deste estudo foi revisar as principais consequências associadas a suplementação alimentar com whey protein. A metodologia consiste numa revisão integrativa da literatura, sendo uma pesquisa bibliográfica exploratória com abordagem qualitativa e descritiva. A amostra inicial continha 130 artigos, dos quais foram submetidos aos critérios de inclusão e exclusão, ao final 6 artigos foram selecionados para compor a discussão. Através dos estudos revisados foi possível concluir que a suplementação nutricional com whey protein traz benefícios, auxiliando na manutenção da massa magra, aumento da força corporal e sobretudo na recuperação muscular pós exercício. No entanto, a grande problemática consiste no consumo indiscriminado e sem orientação profissional, a suplementação excessiva com whey protein pode trazer danos hepáticos e renais, comprometendo a saúde do indivíduo. Neste contexto é importante consultar um profissional capacitado para realizar a indicação produto e a quantidade adequada para cada indivíduo.
Estado nutricional de idosos cardiopatas admitidos em uma unidade de terapia intensiva em Santo Antônio de Jesus, Bahia
Authors: Bahia Francine Coutinho , Barreto Jamille Souza Costa , Ribeiro Priscilla Carvalho da Silva , Santos Adriane de Jesus , Alves Danielle Brito , Santos Thamires Barros dos , Bitencourt Bianca Sena , Barreto Naiara Santos , Magalhães Maria Fernanda Coni , Costa Carlos Alberto Soares da
Published: June 2022

O objetivo dessa pesquisa foi descrever o estado nutricional de idosos cardiopatas admitidos em uma unidade de terapia intensiva no município de Santo Antônio de Jesus, Bahia. Trata-se de um estudo transversal, descritivo, realizado no período de agosto a dezembro de 2019. Foram coletadas informações clínicas, sociodemográficas, hábitos de vida, e laboratoriais. Para a antropometria, foram aferidas as medidas de circunferência do braço (CB), da panturrilha (CP) e foi estimado a massa, estatura e índice de massa corporal (IMC) e classificados. Dados expressos como média ± desvio padrão da média (DPM). A correlação de Pearson, para o escore APACHE II vs. Idade, CP, CB, IMC e massa corporal, com nível de significância de p < 0,05. Foram avaliados 22 idosos (13 homens e 9 mulheres). Maioria com ensino fundamental incompleto (n=20), raça/cor negra (n=12) e com renda menor que 1 salário mínimo (n=14). Diagnóstico de Hipertensão Arterial Sistêmica (n=16), Infarto Agudo do Miocárdio (n=12) e Insuficiência Cardíaca Congestiva (n=12). Baixo peso de acordo com IMC (n=15), eutrofia para a circunferência do braço (n=12) e risco aumentado de desnutrição para a circunferência da panturrilha (n=12). Níveis séricos de uréia acima do recomendado. E correlação inversa (p < 0,02) entre o escore APACHE II em relação ao IMC e massa corporal. No estudo foi observado risco nutricional quando avaliado a CP e o IMC. Logo, o acompanhamento nutricional é fundamental na admissão, visando detectar riscos e intervir com a dietoterapia adequada.
Automatic Voter Re-registration as a Housewarming Gift: Quantifying Causal Effects on Turnout Using Movers
Authors: Kim Seo-young Silvia
Published: June 2022

How much can automatic voter registration (AVR) increase turnout? Unlike many democracies, most American voters face the additional cost of registration, resulting in potential disenfranchisement. AVR is naturally expected to promote turnout, but its causal effects have rarely been quantified due to violations of crucial assumptions. I show that a variation of AVR that targets existing registrants as opposed to eligible non-registrants---termed automatic re-registration (ARR)---increases turnout by 5.8 percentage points. I exploit a natural experiment in a novel administrative dataset; election officials in Orange County, California, notified existing registrants who moved within-county that their residential addresses were automatically updated. The treatment alleviated registrants of re-registration burdens, but only for those who moved before the legal cutoff date, enabling a quasi-random treatment assignment. Contrary to the popular narrative, ARR had no significant effect on the turnout of registered Democrats, but Republicans' and nonpartisans' turnout increased by 8.1 and 7.4 percentage points.
“Elegy Written in a Country Churchyard”: A Critique of the British
Political Agenda
Authors: Al-Gahlith Asad
Published: June 2022

The Restoration and the eighteenth century brought great changes to the islands
of Great Britain. It was a time that witnessed the Act of Union which joined Scotland and
Wales to Britain in 1707. Britain achieved political stability and commercial prosperity.
New standards of politeness and social behavior prevailed to distinguish between civilized
and vulgar citizens. The standards of hierarchy and order helped people participate in and
contribute to the emergence of the British Empire and culture. For the sake of expansion,
Britain started to drive many of its population and soldiers to settle in its newly occupied
territories to encourage the British hegemony in those colonies. For that reason, several
English writers, critics, and poets approached the theme of political and social
transformation in their literary works. Although Thomas Gray’s poem “Elegy Written in a
Country Churchyard” has been predominantly analyzed as a poem that mourns the death
of marginalized poor people, this paper aims to put the poem in its socio-political context.
Within a historical framework, this study argues that the poem does not only lament the
death of England’s underprivileged individuals but that it also contains a prophecy that
started to be fulfilled decades later..
Mohammad Abdul-Wali's They Die Strangers: A Stylistic Approach
to Translation
Authors: Nasser Ali Al-Mwzaiji Khaled
Published: June 2022

Translation is an act of re-reading, re-phrasing and re-creating the original
text for the readers of a foreign language. During the process of translation, the
translators often insert subtle and minor changes in the view of their understanding of
the text and of the expectation of the readers of the foreign language. The following study
seeks to find out such revisions of غرباء يموتون) Yamotona Ghoraba) and the consequent
impact on the text. The analysis is conducted from the methodological perspective of
Translation Stylistics. The study argues that the translation has revised the original text
on several grounds such as structure, information, theme, semantics and lexicon. The
structural modification affects the dramatic motivation of the text which is built over
three divisions of the Aristotelian plot, i.e. beginning, middle, and end, and fails to
register the rising and falling action of the story in the target text. .
Effects of Mid-Gestation Nutrient Restriction, Realimentation, and Parity on the Umbilical Hemodynamics of the Pregnant Ewe
Authors: Vasquez-Hidalgo Manuel A. , Swanson Kendall C. , Vonnahme Kimberly A.
Published: June 2022

Previous studies have reported that nutritional restriction from days 50 to 130 applied in young nulliparous ewes reduces umbilical blood flow (UBF). We hypothesized that during restriction, UBF and fetal and placentome dimensional measurements would decrease compared to adequately fed ewes, but upon realimentation, ewes would have similar UBF as ewes that were not restricted. We also hypothesized that multiparous ewes would be more resilient to nutrient restriction compared to nulliparous ewes. In experiment 1, second-parity Dorset ewes carrying singletons were assigned to an adequate nutrition group (CON, n = 7) or a restricted (60% of CON) group (RES, n = 8), from days 50 to 90 of gestation. In experiment 2, on day 50 of gestation, adult (15-month) nulliparous (NUL; n = 12) and multiparous (MUL; n = 16) Dorset ewes carrying singletons were randomly assigned to receive 100% of NRC recommendations (CON) or 60% of CON (RES). On day 90, all ewes were fed 100% of nutritional recommendations according to body weight. Ewe body weight and conceptus measurements via ultrasonography were recorded every 10 days from days 50 to 130 of gestation. We measured 10 random placentomes, fetal biparietal and abdominal length, and kidney length and width. Doppler mode was used to obtain UBF, pulsatility index (PI), and resistance index (RI). Lamb weight and parturition problems were recorded. In experiment 1, on day 80, UBF decreased (P ≤ 0.05 means separation of unprotected F test), placentome size tended to decrease (P ≤ 0.10), and PI and RI tended to increase in RES vs. CON ewes (P ≤ 0.10). In experiment 2, there were no three-way interactions or main effects of treatments on UBF, PI, RI, and placentome size (P ≥ 0.57). There was a parity-by-day interaction (P < 0.05) for RI, but UBF was not affected by parity or diet. After realimentation, there was no effect of treatment on ultrasound measurements in both experiments. At birth, lambs and placental measurements were not different (P ≥ 0.43). Restriction from days 50 to 90 does not seem to influence umbilical hemodynamics or conceptus growth in adult white face sheep, regardless of parity.
Screening Strategies for High-Yield Chinese Hamster Ovary Cell Clones
Authors: Yang Wenwen , Zhang Junhe , Xiao Yunxi , Li Wenqing , Wang Tianyun
Published: June 2022

Chinese hamster ovary (CHO) cells are by far the most commonly used mammalian expression system for recombinant expression of therapeutic proteins in the pharmaceutical industry. The development of high-yield stable cell lines requires processes of transfection, selection, screening and adaptation, among which the screening process requires tremendous time and determines the level of forming highly productive monoclonal cell lines. Therefore, how to achieve productive cell lines is a major question prior to industrial manufacturing. Cell line development (CLD) is one of the most critical steps in the production of recombinant therapeutic proteins. Generation of high-yield cell clones is mainly based on the time-consuming, laborious process of selection and screening. With the increase in recombinant therapeutic proteins expressed by CHO cells, CLD has become a major bottleneck in obtaining cell lines for manufacturing. The basic principles for CLD include preliminary screening for high-yield cell pool, single-cell isolation and improvement of productivity, clonality and stability. With the development of modern analysis and testing technologies, various screening methods have been used for CLD to enhance the selection efficiency of high-yield clonal cells. This review provides a comprehensive overview on preliminary screening methods for high-yield cell pool based on drug selective pressure. Moreover, we focus on high throughput methods for isolating high-yield cell clones and increasing the productivity and stability, as well as new screening strategies used for the biopharmaceutical industry.
Conductive Collagen-Based Hydrogel Combined With Electrical Stimulation to Promote Neural Stem Cell Proliferation and Differentiation
Authors: Xu Xinzhong , Wang Lin , Jing Juehua , Zhan Junfeng , Xu Chungui , Xie Wukun , Ye Shuming , Zhao Yao , Zhang Chi , Huang Fei
Published: June 2022

Injectable biomimetic hydrogels are a promising strategy for enhancing tissue repair after spinal cord injury (SCI) by restoring electrical signals and increasing stem cell differentiation. However, fabricating hydrogels that simultaneously exhibit high electrical conductivities, excellent mechanical properties, and biocompatibility remains a great challenge. In the present study, a collagen-based self-assembling cross-linking polymer network (SCPN) hydrogel containing poly-pyrrole (PPy), which imparted electroconductive properties, is developed for potential application in SCI repair. The prepared collagen/polypyrrole (Col/PPy)-based hydrogel exhibited a continuous and porous structure with pore sizes ranging from 50 to 200 μm. Mechanical test results indicated that the Young’s moduli of the prepared hydrogels were remarkably enhanced with PPy content in the range 0–40 mM. The conductivity of Col/PPy40 hydrogel was 0.176 ± 0.07 S/cm, which was beneficial for mediating electrical signals between tissues and accelerating the rate of nerve repair. The investigations of swelling and degradation of the hydrogels indicated that PPy chains interpenetrated and entangled with the collagen, thereby tightening the network structure of the hydrogel and improving its stability. The cell count kit-8 (CCK-8) assay and live/dead staining assay demonstrated that Col/PPy40 coupled with electrical simulation promoted the proliferation and survival of neural stem cells (NSCs). Compared with the other groups, the immunocytochemical analysis, qPCR, and Western blot studies suggested that Col/PPy40 coupled with ES maximally induced the differentiation of NSCs into neurons and inhibited the differentiation of NSCs into astrocytes. The results also indicated that the neurons in ES-treated Col/PPy40 hydrogel have longer neurites (170.8 ± 37.2 μm) and greater numbers of branch points (4.7 ± 1.2). Therefore, the prepared hydrogel system coupled with ES has potential prospects in the field of SCI treatment.
Mapping of the sGC Stimulator BAY 41-2272 Binding Site on H-NOX Domain and Its Regulation by the Redox State of the Heme
Authors: Makrynitsa Garyfallia I. , Argyriou Aikaterini I. , Zompra Aikaterini A. , Salagiannis Konstantinos , Vazoura Vassiliki , Papapetropoulos Andreas , Topouzis Stavros , Spyroulias Georgios A.
Published: June 2022

Soluble guanylate cyclase (sGC) is the main receptor of nitric oxide (NO) and by converting GTP to cGMP regulates numerous biological processes. The β1 subunit of the most abundant, α1β1 heterodimer, harbors an N-terminal domain called H-NOX, responsible for heme and NO binding and thus sGC activation. Dysfunction of the NO/sGC/cGMP axis is causally associated with pathological states such as heart failure and pulmonary hypertension. Enhancement of sGC enzymatic function can be effected by a class of drugs called sGC “stimulators,” which depend on reduced heme and synergize with low NO concentrations. Until recently, our knowledge about the binding mode of stimulators relied on low resolution cryo-EM structures of human sGC in complex with known stimulators, while information about the mode of synergy with NO is still limited. Herein, we couple NMR spectroscopy using the H-NOX domain of the Nostoc sp. cyanobacterium with cGMP determinations in aortic smooth muscle cells (A7r5) to study the impact of the redox state of the heme on the binding of the sGC stimulator BAY 41-2272 to the Ns H-NOX domain and on the catalytic function of the sGC. BAY 41-2272 binds on the surface of H-NOX with low affinity and this binding is enhanced by low NO concentrations. Subsequent titration of the heme oxidant ODQ, fails to modify the conformation of H-NOX or elicit loss of the heme, despite its oxidation. Treatment of A7r5 cells with ODQ following the addition of BAY 41-2272 and an NO donor can still inhibit cGMP synthesis. Overall, we describe an analysis in real time of the interaction of the sGC stimulator, BAY 41-2272, with the Ns H-NOX, map the amino acids that mediate this interaction and provide evidence to explain the characteristic synergy of BAY 41-2272 with NO. We also propose that ODQ can still oxidize the heme in the H-NOX/NO complex and inhibit sGC activity, even though the heme remains associated with H-NOX. These data provide a more-in-depth understanding of the molecular mode of action of sGC stimulators and can lead to an optimized design and development of novel sGC agonists.
Impact of Metformin Treatment on Human Placental Energy Production and Oxidative Stress
Authors: Tarry-Adkins Jane L. , Robinson India G. , Reynolds Rebecca M. , Aye Irving L. M. H. , Charnock-Jones D. Stephen , Jenkins Benjamin , Koulmann Albert , Ozanne Susan E. , Aiken Catherine E.
Published: June 2022

Metformin is increasingly prescribed in pregnancy, with beneficial maternal effects. However, it is not known how metformin-treatment impacts metabolism and energy production in the developing feto-placental unit. We assessed the human placental response to metformin using both in vivo and in vitro treated samples. trophoblasts were derived from placentas collected from non-laboured Caesarean deliveries at term, then treated in vitro with metformin (0.01 mM, 0.1 mM or vehicle). Metformin-concentrations were measured using liquid-chromatography mass-spectrometry. Oxygen consumption in cultured-trophoblasts was measured using a Seahorse-XF Mito Stress Test. Markers of oxidative-stress were assayed using qRT-PCR. Metformin-transporter mRNA and protein-levels were determined by quantitative RT-PCR and Western-blotting respectively. Metformin concentrations were also measured in sample trios (maternal plasma/fetal plasma/placental tissue) from pregnancies exposed to metformin on clinical-grounds. Maternal and fetal metformin concentrations in vivo were highly correlated over a range of concentrations (R2 = 0.76, p < 0.001; average fetal:maternal ratio 1.5; range 0.8–2.1). Basal respiration in trophoblasts was reduced by metformin treatment (0.01 mM metformin; p < 0.05, 0.1 mM metformin; p < 0.001). Mitochondrial-dependent ATP production and proton leak were reduced after treatment with metformin (p < 0.001). Oxidative stress markers were significantly reduced in primary-trophoblast-cultures following treatment with metformin. There is a close linear relationship between placental, fetal, and maternal metformin concentrations. Primary-trophoblast cultures exposed to clinically-relevant metformin concentrations have reduced mitochondrial-respiration, mitochondrial-dependent ATP-production, and reduced markers of oxidative-stress. Given the crucial role of placental energy-production in supporting fetal growth and well-being during pregnancy, the implications of these findings are concerning for intrauterine fetal growth and longer-term metabolic programming in metformin-exposed pregnancies.