Intravascular Imaging in Patients With Complex Coronary Lesions and Chronic Kidney Disease
Authors: Kwon Woochan , Choi Ki Hong , Song Young Bin , Park Yong Hwan , Lee Joo Myung , Lee Jong-Young , Lee Seung-Jae , Lee Sang Yeub , Kim Sang Min , Yun Kyeong Ho , Cho Jae Young , Kim Chan Joon , Ahn Hyo-Suk , Nam Chang-Wook , Yoon Hyuck-Jun , Lee Wang Soo , Jeong Jin-Ok , Song Pil Sang , Doh Joon-Hyung , Jo Sang-Ho , Yoon Chang-Hwan , Hong David , Park Taek Kyu , Yang Jeong Hoon , Choi Seung-Hyuk , Gwon Hyeon-Cheol , Hahn Joo-Yong ,   RENOVATE COMPLEX-PCI Investigators, Lee Hyun-Jong , Ryu Dong R , Park Kyu T , Chang Kiyuk , Kim Seonwoo , Kim Dong-Yeon , Shin Suyoun , Kim Jinshil , Park Jaeyoung , Lee Seunghyun , Kim Euna , Kang Hyein , Hwang Su J , Lee Yeonhui , Joh Hyun S , Im Se Y 
Published: November 2023

Importance

As patients with chronic kidney disease (CKD) are more likely to have complex coronary lesions, intravascular imaging guidance in percutaneous coronary intervention (PCI) for this population could be potentially beneficial.

Objectives

To investigate whether the outcomes of intravascular imaging–guided procedural optimization would be different according to the presence of CKD.

Design, Setting, and Participants

This was a prespecified substudy of RENOVATE-COMPLEX-PCI, a recently published multicenter randomized clinical trial in Korea studying the benefits of intravascular imaging for complex coronary lesions. Patients with complex coronary lesions, with or without CKD, were enrolled between May 2018 and May 2021. Data were analyzed from January to June 2023.

Interventions

PCI in each group was done either under the guidance of intravascular imaging or angiography alone.

Main Outcomes and Measures

The primary end point was target vessel failure (TVF) at the 3-year point, defined as a composite of cardiac death, target vessel–related myocardial infarction, or clinically driven target vessel revascularization.

Results

A total of 1639 patients (1300 male [79.3%]) treated with PCI for complex coronary lesions were stratified into CKD (296 participants) and non-CKD (1343 participants) groups. The mean (SD) age of each group was 70.3 (9.4) and 64.5 (10.1) years, and mean (SD) estimated serum creatinine was 2.9 (5.3) and 0.8 (0.2) mg/dL for CKD and non-CKD groups, respectively. Intravascular imaging–guided revascularization was associated with significantly lower incidence of the primary end point compared with angiography-guided revascularization in both CKD (13.3% vs 23.3%; hazard ratio [HR], 0.51; 95% CI, 0.27-0.93; P = .03) and non-CKD (6.4% vs 9.9%; HR, 0.66; 95% CI, 0.44-0.99; P = .05) groups. The significantly lower incidence of the primary end point was mainly associated with the lower risk of cardiac death or target vessel–related myocardial infarction (9.4% vs 22.2%; HR, 0.39; 95% CI, 0.20-0.76; P = .006) in the CKD group and by target vessel revascularization (3.0% vs 5.5%; HR, 0.55; 95% CI, 0.30-0.99; P = .05) in the non-CKD group. Those with a glomerular filtration rate of at least 30 mL/min/1.73m2 and less than 60 ml/kg/1.73m2 showed the greatest benefit from imaging-guided complex PCI (8.8% vs 21.2%; HR, 0.28; 95% CI, 0.11-0.68; P = .02).

Conclusions and Relevance

In this prespecified cohort substudy of the Randomized Controlled Trial of Intravascular Imaging Guidance versus Angiography-Guidance on Clinical Outcomes After Complex Percutaneous Coronary Intervention trial, intravascular imaging guidance showed clinical benefit over angiography guidance in reducing the risk of TVF, regardless of the presence of CKD. The greatest benefits of imaging-guided complex PCI were observed in stage 3 CKD.

Trial Registration

ClinicalTrials.gov Identifier: NCT03381872