bluuebunny/crossref_metadata_2025 huggingface dataset:
16. GÂY TÊ MẶT PHẲNG MẠC ĐÒN NGỰC DƯỚI SIÊU ÂM CHO PHẪU THUẬT XƯƠNG ĐÒN
Authors: Chung Lê Văn , Hiếu Hà Minh , Việt Lê Chí , Hiếu Nguyễn Hữu
Published: September 2024

Đặt vấn đề: Thần kinh chi phối cảm giác cho xương đòn khá phức tạp, vì thế không có phương pháp gây tê vùng đơn thuần nào tối ưu cho phẫu thuật xương đòn. Gây tê mặt phẳng đòn ngực là một kỹ thuật mới, có hiệu quả giảm đau trong và sau mổ, không ức chế vận động chi trên sau mổ và gây liệt cơ hoành như gây tê đám rối gian cơ bậc thang.
Mục tiêu: Đánh giá hiệu quả vô cảm cho phẫu thuật, ức chế vận động theo thang điểm MBS và đau sau mổ theo thang điểm VAS.
Phương pháp nghiên cứu: Tiến cứu can thiệp loạt ca bệnh. Trong tháng 6/2024, tại Bệnh viện Sài Gòn ITO Phú Nhuận đã tiến hành gây tê mặt phẳng mạc ngực đòn tại 1/3 trong và 1/3 ngoài xương đòn, mỗi bên 10 ml Ropivacaine 0,375% và tê đám rối cổ nông 5 ml Ropivacain 0,375% dưới hướng dẫn siêu âm cho 18 người bệnh từ 18-66 tuổi trong phẫu thuật gãy 1/3 giữa xương đòn.
Kết quả: Thời gian xuất hiện ức chế cảm giác trung bình 2,23 phút, thời gian kéo dài tác dụng giảm đau 410 phút. Tất cả 18 người bệnh đều được phong bế hoàn toàn cho phẫu thuật với thang điểm VAS = 0 đạt tỷ lệ 100%. Không liệt vận động chi trên sau mổ (tỷ lệ 100%), giảm đau sau mổ 24-48 giờ đạt tỷ lệ 100% với VAS < 4 điểm, không dùng Mocphin giảm đau, người bệnh hài lòng với tỷ lệ 100%.
Kết luận: Gây tê mặt phẳng đòn ngực dưới hướng dẫn của siêu âm với Ropivacain là một kỹ thuật mới, dễ thực hiện, an toàn bảo đảm vô cảm tốt cho phẫu thuật và giảm đau sau mổ xương đòn mà không có bất kỳ tác dụng phụ nào, người bệnh rất hài lòng.
24. BÁO CÁO CA BỆNH: TIÊM CỒN HỦY DÂY THẦN KINH TRÊN VAI TRONG ĐIỀU TRỊ ĐAU UNG THƯ DI CĂN XƯƠNG BẢ VAI
Authors: Khánh Nguyễn Duy , Thúy Trần Thị Thu
Published: September 2024

Giới thiệu ca bệnh: Chúng tôi giới thiệu một trường hợp bệnh nhân nữ, 48 tuổi, ung thư di căn xương bả vai, đau dữ dội vùng bả vai, không đáp ứng với các thuốc giảm đau thông thường. Thuốc giảm đau NSAID được sử dụng kết hợp với Opioid, nhưng bệnh nhân vẫn đau nhiều, điểm đau VAS luôn luôn 9/10. Chúng tôi tiến hành tiêm cồn tuyệt đối vào dây thần kinh trên vai làm giảm đáng kể mức độ đau của bệnh nhân ngay sau đó mà không có biến chứng nào. Bệnh nhân được theo dõi giảm đau kéo dài sau 6 tháng với điểm VAS là 2/10, bệnh nhân có thể sinh hoạt hàng ngày trở lại bình thường. Tiêm cồn hủy dây thần kinh trên vai là phương pháp an toàn, hiệu quả và có thể giúp giảm đau lâu dài cho bệnh nhân ung thư di căn xương bả vai.
30. ĐÁNH GIÁ HIỆU QUẢ CỦA MÁY VỖ RUNG LỒNG NGỰC TẦN SỐ CAO TRÊN BỆNH NHÂN THỞ MÁY TẠI KHOA HỒI SỨC TÍCH CỰC 1, BỆNH VIỆN HỮU NGHỊ VIỆT ĐỨC
Authors: Nhung Lê Tuyết
Published: September 2024

Mục tiêu: Đánh giá hiệu quả và tác dụng không mong muốn của máy vỗ rung lồng ngực tần số cao HFCWO trên bệnh nhân thở máy.
Phương pháp nghiên cứu: Tiến cứu, can thiệp lâm sàng, so sánh 2 nhóm bệnh nhân thởmáy: nhóm 1 được vỗ rung lồng ngực bằng máy HFCWO, nhóm 2 được vỗ rung bởi điều dưỡng.
Kết quả: Bệnh nhân có tuổi trung bình 45,09 ± 18,3; BMI 21,98 ± 1,93 kg/m2; lý do nhập viện chủ yếu do tai nạn giao thông (50%); bệnh lý hàng đầu khiến bệnh nhân phải thở máy là các tổn thương thần kinh trung ương (42%).
Trong quá trình vỗ rung bằng máy, nhóm 1 có tần số thở tăng, SpO2 giảm nhẹ so với trước vỗ rung. Sau khi hút đờm, tần số thở và SpO2 không khác biệt so với trước can thiệp. Huyết áp và nhịp tim của bệnh nhân nhóm 1 không có sự thay đổi giữa trước với trong và sau khi sử dụng máy. So với nhóm 2, nhóm 1 có số lần hút đờm trong 24 giờ đầu sau can thiệp nhiều hơn, thời gian thở máy và thời gian nằm ICU ngắn hơn, tần số thở và chỉ số thở nhanh nông ngắn hơn có ý nghĩa thống kê. Quá trình sử dụng máy, chỉ có 4% bệnh nhân vã mồ hôi, không có biến chứng.
Kết luận: Máy vỗ rung HFCWO mang lại hiệu quả trong việc loại trừ chất tiết đường thở, cải thiện triệu chứng hô hấp, bệnh nhân ít bị thay đổi huyết động và hô hấp.
35. ĐÁNH GIÁ HIỆU QUẢ GIẢM ĐAU CỦA PHONG BẾ MẶT PHẲNG CƠ DỰNG SỐNG TRONG PHẪU THUẬT CẮT PHỔI CÓ NỘI SOI HỖ TRỢ
Authors: Thắng Nguyễn Văn , Khánh Ngô Gia , Thắng Nguyễn Toàn
Published: September 2024

Mục tiêu: Nghiên cứu nhằm đánh giá hiệu quả giảm đau và các ảnh hưởng không mong muốn của phương pháp phong bế mặt phẳng cơ dựng sống trong phẫu thuật cắt phổi có nội soi hỗ trợ.
Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang bao gồm 30 bệnh nhân có chỉ định phẫu thuật cắt phổi có nội soi hỗ trợ, được giảm đau bằng phương pháp phong bế mặt phẳng cơ dựng sống một bên có luồn catheter tại Bệnh viện Bạch Mai từ tháng 7/2023 đến tháng 9/2024. Khi VAS trên 4 điểm, bổ sung thêm Ketorolac và chuẩn độ Morphin. Chỉ số đánh giá chính là điểm đau VAS (từ 0-10) khi nằm nghỉ và khi cử động. Một số tác dụng không mong muốn được ghi nhận.
Kết quả: Điểm VAS trung bình khi nằm nghỉ và khi cử động tại hầu hết các thời điểm đánh giá trong 72 giờ sau mổ đều dưới 4 (tương ứng là: 2,03 ± 0,63 điểm và 2,76 ± 0,58 điểm ở giờ thứ 24; 1,97 ± 0,63 điểm và 2,52 ± 0,51 điểm ở giờ thứ 48). Có 10 bệnh nhân (33,33%) cần bổ sung Ketorolac và 8 bệnh nhân (26,67%) cần chuẩn độ Morphin (trung bình là 541,67 ± 144,34 mcg). Trong nghiên cứu không gặp các biến chứng nặng liên quan đến phương pháp phong bế mặt phẳng cơ dựng sống.
Kết luận: Phong bế mặt phẳng cơ dựng sống mang lại hiệu quả giảm đau tốt sau phẫu thuật cắt phổi có nội soi hỗ trợ và chưa ghi nhận các biến chứng nặng liên quan đến kỹ thuật này.
ARTIFICIAL INTELLIGENCE IN THE AGRI-FOOD INDUSTRY
Authors:   Kaunas University of Technology, School of Economics and Business,, Bačiulienė Vaida , Navickas Valentinas ,   Alexander Dubček University of Trenčín
Published: September 2024

The agri-food industry faces productivity challenges due to low levels of automation and a lack of innovative solutions. Artificial intelligence can become a tool to meet these challenges. Existing artificial intelligence solutions are already inevitably changing the agri-food industry. This technology is evolving rapidly and its range of applicability is expanding. The article presents an analysis the model of Benefits, Organizational Readiness and External Pressure (BOE) application to artificial intelligence in the agri-food industry. The model constructs – farm readiness, perceived benefits, external pressure– are analyzed in the agri-food industry. Growing investment in technological innovation in the agri-food industry shows that farms are organized to adopt artificial intelligence technology, realize the benefits, and external pressures accelerate the adoption of this technology. Financial resources are often identified as a major barrier to the use of artificial intelligence on farms, but the lack of financial resources can be overcome as an alternative to new business models in the agri-food industry.
DATABASE OF CIRCULAR ECONOMY ARTICULATED TO SUSTAINABLE DEVELOPMENT IN MEXICO
Authors:   National Technological Institute, Technological Institute of San Luis Potosí, CEA, Mexico, Acosta Patricia Rivera , Elia Martínez Torres Rosa ,   National Technological Institute, Technological Institute of San Luis Potosí, CEA, Mexico, Juana María Huerta González ,   National Technological Institute, Technological Institute of San Luis Potosí, CEA, Mexico, Condey Hugo de la Rosa ,   National Technological Institute, Technological Institute of San Luis Potosí, CEA, Mexico
Published: September 2024

Population growth has been one of the most frequently mentioned causes to explain the overexploitation of natural resources and has been determinant of the current global condition, which is characterized by the increase in the volume of resources exploited, the total consumption of resources and the generation of waste and emissions (SDG, 2015). In this context, research is proposed, with the aim of reviewing and identifying the theoretical bases of the Circular Economy and sustainable development (GRI Standards) to design a qualitative measurement database that allows diagnosing and articulating initiatives, practices, actions and strategies that are being developed and implemented in companies, aimed at achieving the transition to the paradigm of the circular economy, since this represents an opportunity to organize production and consumption in the global economy, as it promotes the four Rs: Reduce, Reuse, Recycle and Recover. The design of the research is in the first stage, of documentary type with descriptive and exploratory scope. It should be noted that various national and international databases were consulted for the search and analysis of information. In the second stage, the design of the database is proposed through a technical methodology, to be used as a tool for sustainability-oriented companies. The preliminary conclusions of this study show how the circular economy is articulated with the dimensions of sustainable development: the economic, social and environmental dimensions of the (UN (2015). It is intended that companies implement the database, as a sustainability tool aligned with the circular economy and Sustainable Development (UN, 2015) and represents an opportunity to give the planet a break.
IMPORTANCE OF THE MATERIALITY OF TAX OPERATIONS IN MEXICO
Authors:   Universidad Juárez Autónoma de Tabasco, México, ALMEIDA CAMBRANO Saira Magaly , MARTÍNEZ JIMÉNEZ Rosa María ,   Universidad Juárez Autónoma de Tabasco, México, Jacinto Castillo Lisbeth ,   Universidad Juárez Autónoma de Tabasco, México
Published: September 2024

The tax authorities in Mexico, due to the improper use of Digital Tax Receipts over the Internet and based on the electronic tax information issued by taxpayers that generate tax evasion, establishes the scheme of Simulated Operations with two aspects, the Companies that Bill Operations Simulated and the Companies that Deduct Simulated Operations, based on article 69-B of the Fiscal Code of the Federation, in which taxpayers are required to demonstrate the materiality of the acts they carry out, that is, the reality of their fiscal operations . The objective of the investigation is to demonstrate the importance of taxpayers adequately and sufficiently documenting the materiality of their operations. Through qualitative research, it is concluded that reviews beyond accounting are necessary for the Tax Administration Service, organizations must prove the materiality of their operations with the following documents obtained from their providers: the veracity of the digital tax receipt online; investigate its administrative, operational and fiscal aspects; the physical location of the establishment; the corporate purpose; your financial capacity; the business model; compliance with your tax obligations; verification of the presumption of non-existence of operations; analysis of contracts and agreements; collection of evidence on purchase orders, orders and bids; and public documents.
SMART CONTRACTS AND BUSINESS DECISION
Authors:   Alexander Dubček University of Trenčín, Krajčo Karol , Siniak Nikolai ,   UMEF university
Published: September 2024

In the last 10 years the blockchain technology has become mainstream research topic because of its features that offers, as: decentralized system, peer to peer (P2P) transaction, distributed consensus, and anonymity properties. Also, the blockchain technology overshadows regulatory problem and technical challenges and one of the opportunities that offers the blockchain technology is the 'smart contract'. A smart contract is a set of programs that can be much better from the traditional contracts for some features which are self-verifying, self-executing and tamper resistant. Also, smart contract with the integration of blockchain technology without which cannot function, is capable of doing a task in real time with very low cost and provide a greater degree of high security level. The aim of this paper is to explain the concept of the smart contract and its components and function. The paper is aimed at presenting the issue of smart contract, blockchain technology. The specific focus was on the application of smart contracts in real estate.
Risk management in Egyptian construction: Comparative analysis of general and banking sectors using advanced quantitative methods
Authors: Abdelhafiez Ehab A.
Published: September 2024

To effectively manage the challenges associated with meeting schedules, costs, and quality requirements in construction projects, it is crucial to address potential risk factors. Despite extensive research on risk management in construction, a significant gap persists concerning the uniformity of risk factors and their effects across various construction project types, geographical locations, and cultural contexts. This research presents a structured three-step approach to risk management, covering risk identification, analysis, and response. The methodology is applied to both the General Construction (GC) and Banking Construction (BC) sectors in Egypt, involving industry professionals through surveys. Quantitative analysis using the Relative Importance Index (RII) and Fuzzy-set theory gauges the influence of each risk factor, while Spearman Ranked Correlation tests differentiate risk profiles between sectors. A comparative analysis highlights Egypt-specific risk factors versus regional or global factors. Key risk factors with high centrality scores are identified, and optimal risk reduction strategies are selected using the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS). The study reveals significant sector-specific risk differences and highlights the need for tailored risk management strategies. Key contributions include identifying vital risk factors, comparing them globally and regionally, and proposing effective mitigation strategies to enhance project timelines, costs, and quality.
The striking mechanisms of innovation theories to create collaborative competitive advantage opportunities in global digital marketing
Authors: Mbaidin Hisham O.
Published: September 2024

This study investigates the ways in which collaboration may provide a competitive advantage in global marketing through focused strategy, differentiation, and cost leadership. The study uses Partial Least Squares Structural Equation Modelling (PLS-SEM) to analyze data and present a comparative analysis of separate and combined strategic approaches. The result of the study implies that differentiation is the main factor influencing the variation in collaborative competitive advantage, which accounts for the largest percentage of explained variance (R² = 0.729). Whereas the combined model also shows a high level of explanatory ability (R² = 0.693). The path coefficient shows that differentiation, focused strategy, and cost leadership have a positive impact on competitive advantage. The integrated model also shows significant indirect effects, highlighting the benefits of combining several strategies. These results suggest that in order to optimize resource allocation and enhance market positioning, firms should adopt a comprehensive approach that incorporates many techniques. This study contributes to the existing research in strategic management by emphasizing the importance of a cohesive strategy in sustaining a competitive advantage in the fast-evolving digital marketing field.
Talent management model: How to boost the central bank’s performance in the disruptive era
Authors: Hartono Imam , Baga Lukman M. , Syarief Rizal , Sukmawati Anggraini
Published: September 2024

Organizations are increasingly acknowledging the vital impact of talent management on boosting their performance. Effective talent management within the central bank is crucial, as it plays an indispensable role in maintaining economic stability and advancing the nation’s financial well-being. The study aims to examine the role of talent management, transformational leadership, organizational climate, employee engagement, employee performance, and organizational commitment in increasing the central bank’s performance. The study uses a quantitative approach by collecting data from 600 sample employees of Bank Indonesia in 30 divisions of departments at the head office, 45 domestic representative offices, and 5 foreign representative offices. The data was analyzed using Structural Equation Modelling-LISREL. The finding shows that transformational leadership has a positive impact on talent management. Talent management has a positive impact on organizational climate, employee engagement, and organizational commitment. Organizational climate has a positive impact on employee engagement. Employee engagement has a positive impact on organizational commitment. Organizational climate, employee engagement, and organizational commitment have a positive impact on employee performance, while talent management does not have a positive impact on employee performance. Employee performance, organizational commitment, and talent management have a positive impact on organizational performance. The study offers valuable insights into talent management practices within central banks. It serves as a guide for central bank management and human capital professionals in formulating policies to enhance performance amidst disruptive times. Additionally, educators can leverage these findings to develop curricula that align more closely with industry demands and produce competent graduates ready to excel on the global stage.
Multi-objective flexible job-shop scheduling in hospital using discrete particle swarm optimization algorithm with adaptive inertia weight (DPSO-AIW)
Authors: Lingkon Md. Limonur Rahman , Dash Adri
Published: September 2024

A multi-objective Flexible Job-shop Scheduling technique for hospitals is proposed using DPSO-AIW i.e. discrete particle swarm optimization with adaptive inertia weight method. The approach encodes the layer of the chromosomes using an operation sequence (OS) and machine assignment (MA) which is a two-layer coding structure. Global selection based on the operation (GSO) of MA and random selection of OS are coupled in the initial population. Rapid non-dominated sorting yields fronts of non-domination, which are necessary for getting the Pareto optimum solution. The diversity of the population is increased during the evolution process by adaptive adjustment of the variation of the weight of inertia, expressed by ω. Then, the Pareto optimal solution found during the process is kept in the Pareto optimal solution set (POS). The discrete particle swarm optimization algorithm is utilized to solve the values of the next generation chromosomes in the discrete domain directly. Lastly, comparisons with certain current techniques and numerical simulation based on two sets of international standard examples are performed, which are already established. The findings from the comparison show that the suggested DPSO-AIW is practical, effective, and more feasible for solving the problem related to the Multi-objective Flexible Job-shop Scheduling Problem.
Barriers to Internationalization: Evidence from Jordanian SMEs
Authors: Alkhalailah Alaa Mohammad , Galdeano-Gómez Emilio , Sorroche-del-Rey Yolanda
Published: September 2024

This study investigates the impact of internationalization barriers on the export performance of Jordanian small and medium-sized enterprises (SMEs). The aim of this study is to investigate how the export performance of SMEs in the furniture industry is influenced by external and internal barriers and what significance these have for international performance. Based on a quantitative research design, data was collected from 318 small and medium-sized Jordanian companies through a survey. Partial least squares structural equation modeling (PLS-SEM) examined the impact of external barriers, including political, economic, legal and socio-cultural challenges, as well as internal barriers, such as financial, management and market-related barriers, on export performance. However, most barriers - whether internal or external - are domestic and have a greater impact on export performance than barriers from abroad. This study enriches RBV theory in relation to the internationalization of small and medium-sized enterprises by providing evidence that firm-specific resources and capabilities are key factors for SMEs both when they face export barriers and when they achieve better performance in foreign activities. The findings provide practical implications for managers, policy makers and practitioners interested in the internationalization of Jordanian SMEs. An important limitation is the cross-sectional design, one-country context, and self-report in survey research. Future studies are recommended to use a longitudinal design, mediating and moderating mechanisms. This study is innovative as it involves a combined investigation of firm-external and firm-internal export barriers and their effects on the internationalization success of Jordanian SMEs.
Assessing the effect of IT infrastructure on project success in the financial sector: The role of project flexibility
Authors: Al-Zagheer Hanady , AL-Obaidly Ghoson Abdulaziz , Freijat Saleh Yahya AL , Akhurshaidah Sara Abd Elhakim Oqlah , Al-Manaseer Sufian Radwan
Published: September 2024

This study investigates the critical role of IT infrastructure and project flexibility in achieving project success within the financial sector. Based on resource-based theory and the dynamic capabilities perspective, we propose a conceptual model wherein IT infrastructure influences project success both directly and indirectly through its impact on project flexibility. Data collected from 190 financial sector professionals were analyzed using PLS-SEM. Our findings provide strong support for all hypothesized relationships. Specifically, we find that IT infrastructure has a significant positive impact on both project success and project flexibility. Furthermore, project flexibility is found to mediate the relationship between IT infrastructure and project success, indicating that a robust IT infrastructure contributes to project success, in part, by fostering greater project flexibility. These findings indicate the strategic importance of IT infrastructure investments for financial institutions seeking to enhance project outcomes in a rapidly changing and increasingly competitive landscape.
Factors affecting Jordanian Islamic banks towards competitive advantage
Authors: Al-Jarrah Mefleh Faisal Mefleh , Badarin Abdalla Mohammad Khalaf Al , Al-Zaqeba Murad Ali Ahmad
Published: September 2024

There are challenges Jordanian Islamic banks face in maintaining and enhancing their competitive advantage in a rapidly evolving and increasingly competitive market. This paper aims to examine the factors that affect Jordanian Islamic banks towards competitive advantage, in addition to examining the roles of strategic intelligence and organizational creativity in enhancing Jordanian Islamic banks' competitiveness. However, this paper relied on the descriptive analytical approach, and the study population included general manager, department manager, branch manager, head of department based on Banks structures and annual reports from 2018 to the end of 2023. A stratified random sample was used, approximately 243 questionnaires were examined. The results indicated that organizational creativity and strategic intelligence play a crucial role in building competitive advantage. Also, organizational creativity contributes to achieving superiority by creating an innovative organizational environment, while strategic intelligence reflects the ability to make smart decisions that enhance competitive effectiveness. This paper also demonstrated the importance of managing and harnessing information effectively in order to enhance strategic intelligence. However, this paper contributes to the understanding of success factors in Islamic banking and provides actionable insights for managers navigating the complexities of the banking sector, emphasizing the importance of innovation, differentiation, and strategic decision-making for sustained growth and competitiveness.
Molecular design and virtual screening of chlorogenic acid analogues as potential CD14 inhibitors
Authors: Poyi Olanike Catherine , Ajima Upke , Alemika Taiwo Emmanuel
Published: September 2024

Cluster of Differentiation-14 (CD14) is a glycosylphosphatidylinositol-anchored protein that binds lipopolysaccharide (LPS) and presents it to the toll-like receptor 4 (TLR4) - myeloid differentiation factor 2 (MD-2) complex. This activity encourages the production and release of regulatory molecules, including cytokines and other inflammatory substances leading to septic shock. Septic shock syndrome is one of the leading causes of mortality in hospital intensive care units (ICUs). Currently, no single therapy has proven effective in septic shock management. One of the most prevalent naturally occurring polyphenols in plants, chlorogenic acids (CGA) have a variety of biological functions that are advantageous to human health including reducing septic shock syndrome. This study aimed to explore analogues of CGA as potential CD14 inhibitors using in silico methods. A structure-based virtual screening was carried out, using a compound library of 69 small molecules (library A) and another optimized library of 69 small molecules (library B) along with the lipid A molecule in the hydrophobic pocket on the NH2- terminal side of the CD14 crystal structure, 1WWL.pdb. Nitrogen-containing derivatives and dicaffeoyl- substituted CGA analogues were found to have better binding affinity when compared to that of CGA and lipid A. CGA analogues were analyzed and seen not to be interacting with active site residues that are important for protecting CD14 from digestion, hence making it unavailable for LPS binding and activation. This study was able to predict potential CD14 inhibitors, which are synthesizable and can go on to be bio-assayed for immunomodulatory activities.
PENGARUH EDUKASI VIDEO TERHADAP PENGETAHUAN PASIEN DENGAN PENYAKIT JANTUNG KORONER (PJK)
Authors: Nilamsari Wenny Putri , Ratri Dinda Monika Nusantara , Shinta Dewi Wara , Afrilla Dian , Hamdani Indri Yuliani , Sari Cinantya Meyta , Handayani Meuthia
Published: September 2024

Kepatuhan terhadap terapi farmakologi menjadi kunci utama dalam pengendalian Penyakit Jantung Koroner (PJK) dimana hal ini akan sangat dipengaruhi oleh tingkat pengetahuan pasien. Penelitian ini bertujuan untuk menilai efektivitas video animasi sebagai media edukasi terhadap peningkatan pengetahuan pasien terkait penggunaan obat-obatan dan metode meningkatkan kepatuhan pada pasien PJK. Penelitian ini bersifat analisis menggunakan desain pre-post test di Rumah Sakit Universitas Airlangga, Surabaya. Bentuk intervensi yang dilakukan adalah dengan edukasi video animasi yang dibuat oleh peneliti dengan durasi 9 menit 51 detik. Video tersebut berisi materi tentang pengenalan penyakit jantung koroner, obat-obatan jantung koroner, dan cara untuk meningkatkan kepatuhan. Selanjutnya pengetahuan akan dievaluasi menggunakan kuesioner berisi 15 pertanyaan yang terdiri dari pertanyaan seputar terapi PJK, manfaat terapi, dan cara meningkatkan kepatuhan dalam pengobatan. Analisa data dilakukan dengan menggunakan uji statistik menggunakan uji Wilcoxon signed rank test (uji non parametrik) . Hasil penelitian ini menunjukkan bahwa dari total sampel 50 pasien, video animasi dapat meningkatkan kepatuhan pasien secara signifikan (p-value 0,000)  dengan nilai rata-rata pengetahuan pasien sebelum edukasi adalah 66.0 ± 1,8 dan setelah edukasi menjadi 92.7 ± 1,3. Proporsi pasien yang mempunyai pengetahuan baik juga mengalami peningkatan secara signifikan (p-value 0,000) yaitu sebanyak 14% sebelum edukasi dan 90% sesudah edukasi. Dengan demikian dapat disimpulkan bahwa terdapat peningkatan pengetahuan pasien terkait obat-obat PJK dan metode meningkatkan kepatuhan setelah dilakukan edukasi dengan menggunakan media video animasi.
STUDI PROFIL KADAR NT-proBNP SEBAGAI LANGKAH AWAL NT-ProBNP GUIDED THERAPY PADA PASIEN GAGAL JANTUNG AKUT
Authors: Anggraeni Rieka Nurul Dwi , Nilamsari Wenny Putri , Alsagaff Mochamad Yusuf , Ratri Dinda Monika Nusantara
Published: September 2024

Selain digunakan sebagai indikator signifikan untuk diagnosis klinis gagal jantung akut, pemeriksaan NT-proBNP juga dapat membantu menentukan tingkat keparahan, memandu strategi pengobatan yang relevan, dan menilai prognosis penyakit jantung. Dari penelitian yang sudah ada sebelumnya diketahui penerapan NT-proBNP guided therapy dapat menurunkan kadar NT-proBNP selama perawatan ≥ 30%. Penelitian ini bertujuan untuk menganalisis profil kadar NT-ProBNP sebagai Langkah awal dalam NT-proBNP guided therapy. Jenis penelitian ini adalah penelitian observasional dengan desain cross sectional. Pengambilan sampel dilakukan di IGD Rumah Sakit Universitas Airlangga selama periode Juni-Agustus 2023 dengan kriteria inklusi pasien AHF berusia ≥ 18 tahun dan didiagnosis AHF secara klinis dengan adanya satu gejala pada HF (dispnea, ortopnea, atau edema) dan satu tanda (rales, edema perifer, asites, atau kongesti vaskular paru pada radiografi dada. Pemeriksaan kadar NT-proBNP menggunakan prinsip Enzyme-Linked Immunosorbent Assay (ELISA) menggunakan metode Chemiluminescent Microparticle Immunoassay (CMI). Analisis data secara deskriptif menunjukkan hasil bahwa daei 39 pasien yang masuk ke dalam kriteria inklusi, terdapat 32 sampel dengan profil kadar NT-proBNP meningkat ≥ 300 pg/mL.
Combination of Radiotherapy and Nimotuzumab for Locally Advanced Nasopharyngeal Carcinoma: A Case Report
Authors: Chusnu Romdhoni Achmad , Fahmi Jordan , Januar Er Putra Achmad , Syamsuri Ibrahim , Purwati Pasaribu Ulinta
Published: September 2024

We present a particular case in which nimotuzumab usage as the chemotherapy for locoregionally advanced NPC gives a better outcome for the patient. A 52-year-old woman came with a history of left side stuffiness, rhinorrhea, epistaxis, and hearing loss since 1.5 years ago. She complained about intracranial symptoms such as headaches, tingling sensation, diplopia, and strabismus on the left side of the face for one year before admission. Biopsy of the nasal cavity in July 2018 showed undifferentiated non-keratinizing carcinoma. CT scan showed a mass in the nasopharyngeal cavity without intracranial extension. A pre-therapeutic CT scan in October 2019 showed a massive intracranial extension with midline shift and perifocal edema. She was diagnosed with stage 4a nasopharyngeal carcinoma. The patient received a combination of 35 times radiotherapy and five times administration of Nimotuzumab. A post-therapeutic CT scan showed a loss of nasopharyngeal mass and intracranial sign. The treatment has improved all symptoms with negligible side effects, and Karnofsky's score is as high as 90. Nimotuzumab showed to give negligible toxicity and is well-tolerated among locally advanced NPC patients. The appropriation of Nimotuzumab in locally advanced NPC with intracranial infiltration was tolerable and showed convincing clinical results.
Thực trạng quản lý hoạt động ứng dụng công nghệ thông tin trong dạy học ở các trường trung học phổ thông quận Ô Môn, thành phố Cần Thơ
Authors: Lê Ngọc Hiếu , Phạm Minh Giản
Published: September 2024

Trước yêu cầu đổi mới giáo dục theo hướng hiện đại, ứng dụng công nghệ thông tin trong dạy học trở thành một xu hướng tất yếu. Bài viết trình bày kết quả khảo sát thực trạng quản lý hoạt động ứng dụng công nghệ thông tin trong dạy học ở các trường trung học phổ thông quận Ô Môn, thành phố Cần Thơ. Đối tượng khảo sát là 31 cán bộ quản lý các trường trung học phổ thông thông qua phiếu khảo sát Google Forms theo thang đo Likert 5 mức độ và xử lý số liệu bằng phần mềm SPSS 26 để đánh giá. Kết quả cho thấy các trường trung học phổ thông trên địa bàn nghiên cứu có triển khai quản lý hoạt động ứng dụng công nghệ thông tin trong dạy học bước đầu đạt được những kết quả nhất định nhưng vẫn tồn tại nhiều hạn chế.
Laparoscopic-assisted vaginoplasty in complex congenital urogenital anomaly: A case report
Authors:   Department of Obstetric and Gynaecology, Luohu Hospital, Shenzhen 518001, China., Qin Chenglu
Published: September 2024

We present a case report of a 15-year-old girl diagnosed with congenital vaginal atresia with ureteral bud and urethral anomaly. This case describes surgical selection and its long-term management.
Management of Crohns disease and its complexities: A case report
Authors:   Department of Medicine, Medical College & Hospital Kolkata, Kolkata, India., Sikdar Niragh
Published: September 2024

Crohn’s Disease (CD) and its complexities are explored through a case report and literature review, shedding light on the multifaceted nature of this chronic inflammatory gastrointestinal disorder. Characterized by unpredictable flare-ups and remissions, CD affects various segments of the gastrointestinal tract.
Pigmentary complications of chemotherapy for metastatic melanoma
Authors:   Department of Dermatology, Hassan II University Hospital Center of Fez, Morocco., Hafsa Hamraoui
Published: September 2024

Induction of multiple eruptive cutaneous nevi has been frequently reported in children with hematologic malignancies and chemotherapy-induced immunosuppression. This is the first report of an adult female patient developing multiple eruptive melanocytic skin lesions
Lactic acidosis in a patient treated with metformin
Authors:   Department of Nephrology, Transplantology, and Internal Medicine, Pomeranian Medical University in Szczecin, Poland., Kabat-Koperska Joanna
Published: September 2024

Metformin is widely recognized as the first-line therapy for type 2 diabetes due to its low cost, safety profile, and potential cardiovascular benefits. However, complications of its use may occur in daily clinical practice, including lactic acidosis
Unveiling the hidden: Point-of-Care Ultrasound (POCUS) reveals the diagnosis of rectus sheath hematoma
Authors:   Aga Khan University, Pakistan., Sajid Sundas
Published: September 2024

A 42-year-old female with abdominal pain and on anticoagulation presented with an acute Rectus Sheath Hematoma (RSH), a rare abdominal pathology. Point-of-Care Ultrasonography (POCUS) was performed at the bedside, revealing a hypoechoic lesion in the left rectus sheath causing mass effect, consistent with RSH
The Work Environment of Primary Health Care Nurses: An Integrative Review
Authors: de Andrade Lucas Lorran Costa , Brehmer Laura Cavalcanti de Farias , Amazonas Bruna Alves Machado , Monteiro Wagner Ferreira , Sicsú Amélia Nunes , Ramos Flávia Regina Souza
Published: September 2024

Introduction: Work activities incorporate physical, social, emotional, and technical elements. In a scenario of constant change, it is imperative to understand the current scientific knowledge on the structure and work conditions of nurses in primary health care (PHC). Objective: To identify, in the scientific literature, the aspects related to the work environment that influence the performance of nurses in PHC. Materials and Methods: This is an integrative literature review conducted in August 2023 in the Lilacs, Cinahl, Web of Science, Medline, Scopus, and Embase databases, following the Prisma 2020 Statement guidelines. The inclusion criteria were complete electronic articles, published in Portuguese, English, or Spanish between 2019 and 2023. This review used the ROBIS instrument to assess the risk of bias. Results: The search found 1,417 records in the databases, of which 20 were selected for the final sample. Of these, 30 % were from 2020 (n = 6), published in Portuguese, English, and Spanish. Brazil had the highest number of publications, with 55 % (n = 11), and qualitative studies represented 55 % (n = 11) of the methodological approaches. The following thematic categories emerged from the analysis: “psychological and emotional elements,” “human resources, materials, and infrastructure,” “interpersonal relationships,” “dissatisfaction,” “violence in the workplace,” and “overload.” Conclusion: The precarious environment in PHC has a negative impact on nurses and the care provided to the population. Improvements in infrastructure, personnel, and work conditions are essential to ensure quality care.
DEVELOPING A TECHNOLOGY FOR PRODUCING LEAD MOLYBDATE FROM MOLYBDENITE CONCENTRATES AND GROWING ITS CRYSTALS AT LOW TEMPERATURE
Authors: Davidyan K.H. , Harutyunyan S.A. , Davidyan A.K. , Hakobyan A.R. , Safaryan T.N.
Published: September 2024

A process has been developed for obtaining high-purity lead molybdate from solutions of ammonium molybdate and lead acetate, which are obtained by processing molybdenite concentrates. This process ensures the stability of the stoichiometric composition of the compound and minimizes the content of its main impurities. It is worth noting that these impurities are the primary cause of instability of the colour of the final product. During the solid-phase synthesis of lead molybdate PbMoO4, it is possible to fom the compound Pb2MoO5 due to the evaporation of molybdenum trioxide and lead oxide.
It is found that obtaining lead molybdate by chemical precipitation from solutions is more preferable and provides up to 99% yield of the required product. It is revealed that the stoichiometric composition of lead molybdate is obtained with an excess of 1% lead acetate. As a result of experiments, it is found that changing the concentration of solutions of ammonium molybdate and lead acetate does not affect the stoichiometric content of lead molybdate.
The process of growing lead molybdate crystals at low temperatures in a silica gel medium at 27°C is indicated. The crystals are formed through diffusion of nutrient solutions containing ammonium molybdate and lead acetate. The method requires simple equipment, and the process of crystal formation is easy to follow. The structure of the silicagel has a significant impact on the growth process and formation rates of the PbMoO4 crystals. The quality of the grown crystals may decrease as the density of the silicagel increases. On the other hand, it has been noted that lead molybdate crystals tend to grow at a very slow pace in low density silica gel, which is also known to be unstable. While it is true that the duration of crystallisation may be considered a disadvantage of this method, it is worth noting that it is possible to obtain homogeneous and colourless crystals.
MATHEMATICAL MODELING OF THE OPTIMAL SELECTION OF BRAKE FRICTION MATERIAL COMPONENTS WITH FUNCTIONAL PROPERTIES
Authors: Meliksetyan N.G. , Aschyan G.H. , Harutyunyan Y.V.
Published: September 2024

Based on the analysis of technical literature, it has been established that in order to improve and scientifically substantiate the process of creating new and more efficient brake friction materials with functional properties, mathematical modeling of the optimal choice of their compositions is required. Having chosen the heat capacity coefficient as a functional parameter, using mathematical modeling, a program for automatically calculating theoretical heat capacity coefficients and selecting components depending on the volumetric content of composite friction materials with functional properties has been developed for the first time. The program is available in the Windows environment, with visualization of the import and export fields of the program using the winforms method. The program provides the ability to calculate the coefficients of specific heat capacity of friction materials by computer input of the values of the coefficients of specific heat capacity of components and select the percentage ratios of components for the development of friction materials with different coefficients of specific heat capacity. A block diagram for program implementation is proposed.
To verify the reliability of the obtained modeling results, various friction materials certified according to the requirements of international standards, as well as the material“Bastenit-8” developed at National Polytechnic University of Armenia, were subjected to experimental research. The material“Bastenit-8”, having a high coefficient of specific heat capacity, shows high performance, and the spread of friction coefficient values does not exceed 5%, which meets the requirements of the international standard. It is shown that specific heat capacity is a functional parameter of brake friction materials. This seriously affects their performance and supports the hypothesis that materials with high heat capacity coefficients have stable tribological characteristics.
MECHANICAL CHARACTERISTICS OF HIGH ALUMINA CEMENT CONTAINING OXIFLUORIDE ADDITIVES OF TRIVALENT ELEMENTS
Authors: Movsisyan B.V. , Grigoryan T.V. , Arutyunyan V.R. , Knyazyan N.B.
Published: September 2024

The formation of crystallohydrates at the early stages of hydration of alumina cement under different conditions and changes in compressive strength is studied. It is revealed that when the cement paste is hydrated below 150C, CAH10 and C12A7Hn are formed, which then turn into C3AH6, C4AH12, AH3 and are the main phases of high-strength cement stone. After completion of the processes of transition of hydration products, the microstructure of cement stone is an accumulation of particles of various calcium hydroaluminates immersed in crystallized AH3. It is established that in the initial period of hydration, there is a sharp increase in the strength of cement stone. At endurance 5 min, the strength increases sharply to ~ 25 MPa, then gradually increases to ~ 30 MPa. The intensity of the increase at the early stages of the gyration process is also associated with an increase in the temperature of the system. The mechanism of development of cement stone strength from time to time is explained by the fact that at the first stage of active hydration of aluminates, an amorphous layer forms on the surfaces of cement particles, slowing down the reaction rate. At a late stage, due to the crystallization of the amorphous layer and an increase in diffusion, hydration reactions progress, increasing the value of the compressive strength of the cement stone. Electron microscopic studies have revealed that the gel of aluminum hydrate AH3 formed after the hydration of pure aluminates C12A7 and CA, is completely crystallized. The relationship between the hydration of alumina cement solutions and their compressive strength at the early stages of setting has been investigated. X-ray phase analysis of the phase composition of the primary products of cement hydration and their further transformation reveals a certain relationship between the strength of the samples and phase transformations in hydrates.
Research Progress on Regulation of Nrf2/Keap1 Signaling Pathway by Traditional Chinese Medicine in the Treatment of Diabetic Nephropathy
Authors: Haung Lei , Ding YanLin , Yu XiaoYong
Published: September 2024

Diabetic kidney disease (DKD) is one of the more common microvascular diseases in diabetes, and its pathogenesis has not been fully revealed. Oxidative stress and inflammatory reaction play an important role in its pathogenesis. Studies have proved that the nuclear factor E2 related factor2(Nrf2)/Kelch like epichlorohydrin related protein-1 (Keap1) pathway is a signal pathway closely related to the occurrence and development of DKD, participating in the antioxidant stress and inflammatory response of the body, and is one of the important targets in the treatment of diabetes nephropathy. Some traditional Chinese medicine and related compound formulas can regulate the Nrf2/Keap1 signaling pathway to resist oxidative stress and anti-inflammatory effects, thereby improving renal function and delaying renal fibrosis, such as Tripterygium wilfordii glycosides, berberine, baicalin IV, icariin, resveratrol, emodin, curcumin, asiatica acid, tangshenning, compound asiatica, etc. Therefore, focusing on the composition and activation of the Nrf2/Keap1 signaling pathway, this paper summarizes the mechanism and current research progress of traditional Chinese medicine intervention in the treatment of DKD through the Nrf2/Keap1 signaling pathway, in order to provide new theoretical references for the prevention and treatment of DKD with traditional Chinese medicine and the development of new drugs.
Dispelling Stasis and Detoxification Method based on COX-2/PGE2 Pathway
Authors: Xi Chunhua , Cao Ruotong , Shen Jialin , Zhao Weihan
Published: September 2024

Gastric cancer is a disease with high mortality rate among global cancers, and its survival rate is extremely low and treatment prognosis is extremely poor, which seriously impedes the development of the world economy. Pre-cancerous gastric lesion (PLGC) is the early stage of gastric cancer, so far modern medicine has no effective measures to prevent and reverse the development of PLGC to gastric cancer, the pathogenesis of PLGC is not yet clear, but the theory of inflammatory cancer transformation is now more popular. Therefore, the COX-2/PGE2 pathway can generate an inflammatory environment, promote cell proliferation, inhibit apoptosis, promote angiogenesis and other processes, so that PLGC gradually develops into gastric cancer. According to Chinese medicine, gastric cancer is mostly caused by stagnation of qi and blood stasis, and the internalisation of fire and toxicity, so the elimination of blood stasis and detoxification fits the pathogenesis of the disease, and Chinese medicine can play an anti-inflammatory role in the COX-2/PGE2 pathway by inhibiting cell proliferation, promoting apoptosis, and inhibiting the formation of capillaries, which can prevent PLGCs from progressing to gastric cancer, and thus preventing the development of gastric cancer. This article reviews the pathogenesis of PLGC by COX-2/PGE2 signalling pathway, and the progress of TCM drugs targeting PLGC based on COX-2/PGE2 pathway by dispelling stasis and detoxification, with the aim of providing more theoretical basis and prescription research for clinical practice.
Research Progress on the Current Status and Intervention Strategies of Hypoxaemia in General Anaesthesia Patients during the Postoperative Awakening Period
Authors: Wei Yunshi , Xiang Ya , He Liu , Ling Chaoling , Liu Fangyin
Published: September 2024

To introduce the current situation of the occurrence of postoperative hypoxemia during the awakening period of general anesthesia patients, to analyze the influencing factors of the occurrence of hypoxemia during the awakening period of general anesthesia patients, and to summarize the intervention strategies of hypoxemia during the awakening period of general anesthesia patients, with a view to promoting the medical personnel's understanding of the risk factors of hypoxemia during the awakening period of general anesthesia patients, and to provide references for the development of reasonable intervention programs in the future.