bluuebunny/crossref_metadata_2025 huggingface dataset:
Le comunità giudaiche nell’ecumene severiana. Alcuni aspetti della politica di Settimio Severo nei confronti degli Iudaei
Authors: Bono Martina
Published: June 2023

Jews in the Severan oecumene. Some aspects of Septimius Severus’ policy towards the Iudaei – This paper aims at exploring some aspects concerning the condition of the Jewish community during the Severan period, especially focussing on the political and administrative reorganisation carried out by Septimius Severus in the first years of his principate. Our main goal is to find out whether and to what extent a correlation can be detected between the administrative arrangement given by Septimius Severus (beginning with the defeat of Pescennius Niger in 194/195 AD) to the Egyptian, African and Syriac territories of the Empire, where many Jewish were then living, and the socio-economic conditions of these groups, dwelling particularly on a passage from Ulpian (Dig. L 2, 3, 3) concerning the municipal career of the Jews.
Note su un’ideale moneta ellenica Per un contributo a Platone, Leg. V 742a-c
Authors: Masone Leonardo
Published: June 2023

Notes on an ideal Hellenic coin. For a contribution to Plato, Leg. V 742a-c – The colony of Laws, described by Plato in his last dialogue, represents a concrete attempt to create a new city. In this sense, the philosopher proposes a new economic policy, at the basis of which the idea of a currency that acts as a currency for all the activities within the polis is advanced. A real currency that has similar characteristics to the one of real cities. But also for external activities: this is, perhaps, a novelty in Plato’s thinking, that we must look at in order to verify any elements of originality for a new Greek monetary policy.
Simulation of neutron irradiation-induced recrystallization of tungsten
Authors: Zhang Guo-Shuai , Yin Chao , Wang Zhao-Fan , Chen Ze , Mao Shi-Feng , Ye Min-You ,   School of Nuclear Sciences and Technology, University of Science and Technology of China, Hefei 230026, China
Published: June 2023

Tungsten is the candidate for divertor target material in future fusion reactors. The tungsten divertor target is expected to long serve in a harsh environment of high temperature and high-energy neutron irradiation. This can lead to neutron irradiation-induced recrystallization of tungsten, thereby increasing the possibility of intergranular brittle failure and compromising the safe operation of the divertor. Thus, clarifying the mechanism of neutron irradiation-induced tungsten recrystallization is important. However, the current model, which only considers the irradiation-enhanced effect on recrystallization driving force, underestimates the irradiation effect on recrystallization compared with the results observed in recent high-temperature neutron irradiation experiments in the HFIR reactor. It indicates that other irradiation effects can also influence the recrystallization process.

In this study, we introduce the irradiation-enhanced grain boundary migration factor (R) into the established irradiation-induced recrystallization kinetic model, on the assumption that the grain boundary migration velocity is proportional to the self-diffusion coefficient. The simulation results show that after considering both irradiation-enhanced recrystallization driving force and grain boundary migration effect, the calculated half-recrystallization time (\begin{document}${t}_{{X}\text{}=\text{}0.5}$\end{document}) at 850 ℃ from the model matches the one obtained in the neutron irradiation experiment in the HFIR reactor. This result indicates that the irradiation-enhanced grain boundary migration effect is one of the important factors affecting irradiation-induced recrystallization. In addition, the difference between irradiated and unirradiated tX=0.5 decreases with temperature increasing. This phenomenon is due to the fact that as the temperature increases, the contribution of irradiation defects to the driving force for recrystallization decreases owing to the irradiation defect recombination. Moreover, the increase of thermal activation diffusion coefficient is more significant than the increase of the irradiation-enhanced diffusion coefficient. These findings suggest that the thermal activation effect eventually dominates the recrystallization process over the irradiation effect as temperature increases.
Diameter dependence of transport through nuclear pore complex mimics studied using optical nanopores
Authors: Klughammer Nils , Barth Anders , Dekker Maurice , Fragasso Alessio , Onck Patrick R , Dekker Cees
Published: June 2023

The nuclear pore complex (NPC) regulates the selective transport of large biomolecules through the nuclear envelope. As a model system for nuclear transport, we construct NPC mimics by functionalizing the pore walls of freestanding palladium zero-mode waveguides with the FG-nucleoporin Nsp1. This approach enables the measurement of single-molecule translocations through individual pores using optical detection. We probe the selectivity of Nsp1-coated pores by quantitatively comparing the translocation rates of the nuclear transport receptor Kap95 to the inert probe BSA over a wide range of pore sizes from 35 nm to 160 nm. Pores below 55 ± 5 nm show significant selectivity that gradually decreases for larger pores. This finding is corroborated by coarse-grained molecular dynamics simulations of the Nsp1 mesh within the pore, which suggest that leakage of BSA occurs by diffusion through transient openings within the dynamic mesh. Furthermore, we experimentally observe a modulation of the BSA permeation when varying the concentration of Kap95. The results demonstrate the potential of single-molecule fluorescence measurements on biomimetic NPCs to elucidate the principles of nuclear transport.
A new look at the architecture and dynamics of the Hydra nerve net
Authors: Keramidioti Athina , Schneid Sandra , Busse Christina , Cramer von Laue Christoph , Bertulat Bianca , Salvenmoser Willi , Hess Martin , Alexandrova Olga , Glauber Kristine M , Steele Robert E , Hobmayer Bert , Holstein Thomas W , David Charles N
Published: June 2023

The Hydra nervous system is the paradigm of a ‘simple nerve net’. Nerve cells in Hydra, as in many cnidarian polyps, are organized in a nerve net extending throughout the body column. This nerve net is required for control of spontaneous behavior: elimination of nerve cells leads to polyps that do not move and are incapable of capturing and ingesting prey (Campbell, 1976). We have re-examined the structure of the Hydra nerve net by immunostaining fixed polyps with a novel antibody that stains all nerve cells in Hydra. Confocal imaging shows that there are two distinct nerve nets, one in the ectoderm and one in the endoderm, with the unexpected absence of nerve cells in the endoderm of the tentacles. The nerve nets in the ectoderm and endoderm do not contact each other. High-resolution TEM (transmission electron microscopy) and serial block face SEM (scanning electron microscopy) show that the nerve nets consist of bundles of parallel overlapping neurites. Results from transgenic lines show that neurite bundles include different neural circuits and hence that neurites in bundles require circuit-specific recognition. Nerve cell-specific innexins indicate that gap junctions can provide this specificity. The occurrence of bundles of neurites supports a model for continuous growth and differentiation of the nerve net by lateral addition of new nerve cells to the existing net. This model was confirmed by tracking newly differentiated nerve cells.
Exploring the molecular basis of resistance to Botrytis cinerea in chickpea genotypes through biochemical and morphological markers
Authors: Thakur Richa , Sharma Sucheta , Devi Rajni , Sirari Asmita , Tiwari Rahul Kumar , Lal Milan Kumar , Kumar Ravinder
Published: June 2023

Chickpea (Cicer arietinum L.) is an important pulse crop around the globe and a valuable source of protein in the human diet. However, it is highly susceptible to various plant pathogens such as fungi, bacteria, and viruses, which can cause significant damage from the seedling phase until harvest, leading to reduced yields and affecting its production. Botrytis cinerea can cause significant damage to chickpea crops, especially under high humidity and moisture conditions. This fungus can cause grey mould disease, which can lead to wilting, stem and pod rot, and reduced yields. Chickpea plants have developed specific barriers to counteract the harmful effects of this fungus. These barriers include biochemical and structural defences. In this study, the defence responses against B. cinerea were measured by the quantification of biochemical metabolites such as antioxidant enzymes, malondialdehyde (MDA), proline, glutathione (GSH), H2O2, ascorbic acid (AA) and total phenol in the leaf samples of chickpea genotypes (one accession of wild Cicer species, viz. Cicer pinnatifidum188 identified with high level of resistance to Botrytis grey mould (BGM) and a cultivar, Cicer arietinumPBG5 susceptible to BGM grown in the greenhouse). Seedlings of both the genotypes were inoculated with (1 × 104 spore mL−1) inoculum of isolate 24, race 510 of B. cinerea and samples were collected after 1, 3, 5, and 7 days post-inoculation (dpi). The enhanced enzymatic activity was observed in the pathogen-inoculated leaf samples as compared to uninoculated (healthy control). Among inoculated genotypes, the resistant one exhibited a significant change in enzymatic activity, total phenolic content, MDA, proline, GSH, H2O2, and AA, compared to the susceptible genotype. The study also examined the isozyme pattern of antioxidant enzymes at various stages of B. cinerea inoculation. Results from scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy revealed that BGM had a more significant impact on susceptible genotypes compared to resistant ones when compared to the control (un-inoculated). In addition, SEM and FTIR spectroscopy analyses confirmed the greater severity of BGM on susceptible genotypes compared to their resistant counterparts. Our results suggest the role of antioxidant enzymes and other metabolites as defence tools and biochemical markers to understand compatible and non-compatible plant-pathogen interactions better. The present investigation will assist future plant breeding programs aimed at developing resistant varieties.
The cytotoxicity effect of 7-hydroxy-3,4-dihydrocadalene from Heterotheca inuloides and semisynthetic cadalenes derivates towards breast cancer cells: involvement of oxidative stress-mediated apoptosis
Authors: Mendoza-Fuentes Alan , González-Burgos Elena , Aparicio Trejo Omar Emiliano , Delgado-Lamas Guillermo , Rodríguez-Chávez José Luis , Pedraza Chaverri José , Gómez-Serranillos M. Pilar , Araiza-Olivera Daniela
Published: June 2023

Background

Heterotheca inuloides, traditionally employed in Mexico, has demonstrated anticancer activities. Although it has been proven that the cytotoxic effect is attributed to cadinane-type sesquiterpenes such as 7-hydroxy-3,4-dihydrocadalene, the mechanism of action by which these agents act in tumor lines and their regulation remain unknown. This study was undertaken to investigate for first time the cytotoxic activity and mechanism of action of 7-hydroxy-3,4-dihydrocadalene and two semi-synthetic cadinanes derivatives towards breast cancer cells.

Methods

Cell viability and proliferation were assayed by thiazolyl blue tetrazolium bromide (MTT) assay and Trypan blue dye exclusion assay. Cell migration measure was tested by wound-healing assay. Moreover, the reactive oxygen species (ROS) and lipid peroxidation generation were measured by 2′,7′-dichlorofluorescein diacetate (DCFH-DA) assay and thiobarbituric acid reactive substance (TBARS) assay, respectively. Furthermore, expression of caspase-3, Bcl-2 and GAPDH were analyzed by western blot.

Results

The results showed that 7-hydroxy-3,4-dihydrocadalene inhibited MCF7 cell viability in a concentration and time dependent manner. The cytotoxic potency of semisynthetic derivatives 7-(phenylcarbamate)-3,4-dihydrocadalene and 7-(phenylcarbamate)-cadalene was remarkably lower. Moreover, in silico studies showed that 7-hydroxy-3,4-dihydrocadalene, and not so the semi-synthetic derivatives, has optimal physical-chemical properties to lead a promising cytotoxic agent. Further examination on the action mechanism of 7-hydroxy-3,4-dihydrocadalene suggested that this natural product exerted cytotoxicity via oxidative stress as evidenced in a significantly increase of intracellular ROS levels and in an induction of lipid peroxidation. Furthermore, the compound increased caspase-3 and caspase-9 activities and slightly inhibited Bcl-2 levels. Interestingly, it also reduced mitochondrial ATP synthesis and induced mitochondrial uncoupling.

Conclusion

Taken together, 7-hydroxy-3,4-dihydrocadalene is a promising cytotoxic compound against breast cancer via oxidative stress-induction.
The influence of green accounting on the company profitability
Authors: Sidarta Alphasyah Lazuardy , Sukoharsono Eko Ganis , Laily Alfauzia Noer Rochmatul
Published: June 2023

This study aims to investigate the influence of green accounting on company profitability.  This study is conducted due to the negative ecological impact of industrial business processes, such as environmental pollution, which can affect organisms in the surrounding area. This study focuses primarily on chemical industries listed on the Indonesia Stock Exchange in 2021 and evaluates them using PROPER. This study employs a purposive sampling method and uses secondary data of the 2021 annual reports of the industry as its source of information. The result of the study finds that green accounting and environmental performance positively impact on company profitability. Environmental performance has a positive effect on company profitability (ROA and ROE), meaning that the higher the PROPER rating, the greater the company's profitability. Companies are advised to be more concerned about the environment because their business processes must rely on natural resources that are detrimental to the environment and the people who experience it. Businesses must create a green background to have a more significant positive impact on the environment or industry.
Assessment of Applicability and Usefulness of the Messages Delivered by Kisan Mobile Advisory Service as Perceived by the Beneficiaries of KVK, Raipur
Authors: Nigam Aastha , Awasthi H. K. , Pandey P. K.
Published: June 2023

This study investigates the applicability and usefulness of messages delivered by the Kisan Mobile Advisory Service in the Raipur district of Chhattisgarh. A total of 120 farmers were chosen at random from 10 villages in two blocks, Arang and Abhanpur for the purpose of study. The study reveals that the applicability of messages related to pest management were perceived ‘always applicable’ by 85.84 per cent respondents with highest overall MPS (92.92).Likewise the applicability of messages related to disease management were perceived ‘always applicable’ by 85 per cent respondent farmers with second highest overall MPS (92.5).While the messages related to fisheries were reported least applicable with overall MPS (8). As far as the usefulness is concerned the respondents believed that the messages were useful in improving the agriculture knowledge, Nursery management in different crops, Nutrient management, Increases farm yield while the messages where least useful in Creating awareness about health and hygiene. The overall usefulness of the messages was found to be moderate by 55.84% respondents, most useful by 35% and less useful by 9.16% respondents.
Identification of Different Promotional Strategy and Promotional Tool for Enhancing the Acceptability of Systematic Insecticide in Kurukshetra District, Haryana, India
Authors: Aarti  , Barker Nitin
Published: June 2023

India’s people live in rural areas and their main occupation is agriculture.  A Paddy is the seed of the grass species Oryzasativa (Asian rice) or Oryzaglaberrima (African rice). As a cereal grain, it is the most widely consumed staple food for a large part of the world's human population, especially in Asia. A Paddy is the most important cereal food crop of India. It occupies about 24 percent of gross cropped area of the country. It plays vital role in the national food grain supply. Rice contributes 43 percent of total food grain production and 46 percent of the total cereal production specially for most of the people of South-East Asia. Production of paddy in India is highest in West Bengal state, but productivity of paddy in India is highest in Punjab state. A Sample of 100 respondents were drawn by proportional to area under paddy.
Knowledge of the Respondents towards Paddy Production Technology in Mahabubnagar District of Telangana, India
Authors: Monica Bheempogu , Mazhar Syed H.
Published: June 2023

The present study aims to highlights the Knowledge of respondents towards paddy production technology in Mahabubnagar district of Telangana, India. A structured interview was conducted among that 120 farmers were selected from 20 villages, with six respondents from each village. Data were collected by using the pre-tested schedule and analysed using appropriate statistical tools. It was found that most respondents were having a medium level of socio-economic profile. On analysing the knowledge level, the education level, the highest number of respondents i.e., 53.33 percent were having a medium level of knowledge followed by percent had high and 21.67 percent had low levels. On analysing the education level, the highest number of respondents i.e., 53.33 percent were having a medium level of education followed by 33.33 percent having high and 12.5 percent having low levels. Independent variables namely age education annual income land holding, mass media exposure extension contacts, and economic motivation had positive and significant relationships with adoption respectively. The major constraints faced were delay in doing due to monsoon prolong, complexity, lack of skill and knowledge, unavailability of laborers, and hang cost of input and storage facilities respectively.
The Knowledge and Accuracy Roles in Explaining the Business Communication on Customer Satisfaction inside SMEs
Authors: Nurjannah Nurjannah , Nurimansjah Ris Akril , Yunus Muhammad Haekal , Munawir Munawir , Erwina Erwina
Published: June 2023

The literature explains that some SMEs tend to deal with a business communication problem during the market share customer satisfaction development, for example, there is a personal interest of employee, which is the tendency in changing the information inside the company in every management levels, or the lack of product knowledge of sales person in communicating the detail information of product/service to the potential buyers. As such, this study aims to explore the role of business communication on customer satisfaction through the emphasis of knowledge and accuracy, given that there are less literatures explain such role, especially within the developing countries. Through the application of quantitative method, this study collects the data from SMEs throughout a distribution of 115 questionnaires. As theoretical implication, this study finds that knowledge and accuracy inside business communication play a significant role on customer satisfaction development. In addition, as managerial contribution, this study also recommends a constructive guideline for business owners, especially SMEs to enhance their marketing strategy.
Effect of Different Organic Manure and Inorganic Fertilizer on Growth, Yield and Quality of Okra (Abelmoschus esculentus L.)
Authors: Yadav Shankar Lal , Topno Samir Ebson , Bahadur Vijay , Prasad V. M. , Kerketta Anita
Published: June 2023

The experimentation entitled Effect of different organic manure and inorganic fertilizer on growth, yield and quality of okra (Abelmoschus esculentus L.) during kharif (Rainy) season at Horticulture Research Farm, Department of Horticulture, Naini Agricultural Institute, Sam Higginbottom University of Agriculture, Technology & Sciences, and PRAYAGRAJ (UP) during 2022. Due to the heavy application of chemical and fertilizer, land and water bodies are getting polluted So, to reduce the degradation of soil, we have used combination of organic and inorganic sources of nutrients. The experiment was laid out in a randomized block design with three replications and thirteen treatment combinations. F1 Hybrid Covi Plus was selected for this study. We have found that application of 75% NPK and 25% of vermicompost respectively gave highest yield (19.57 t/ha).
Assessment of Physico-Chemical Properties of Soil from Different Blocks of Sahibganj District, Jharkhand, India
Authors: Kumari Shikha , Swaroop Narendra , Thomas Tarence , Kumar Rajnesh
Published: June 2023

An evaluation of physico-chemical properties of 27 soil samples from 3 different blocks ie., Sahibganj, Borio and Taljhari of Sahibganj district (Jharkhand) in different depths (0–15, 15–30 and 30–45 cm) was carried out during of 2022-2023. The present investigation was objectified as determination of soil Physico-chemical properties to analyse the soil fertility status with finding out the deficiency and toxicity of different soil nutrients. Soil samples were analyzed using standard laboratory techniques and statistical analysis. The treatments in them study were arranged in a Completely Randomized Design. The bulk density of the soils varied from 1.13 to 1.53 Mg m-3, while the particle density ranged from 2.24 to 2.69 Mg m-3. The percentage of pore space was between 36.88 and 49.55% and water holding capacity was between 31.11 and 44.71%. Soil pH varied from 6.28 to 7.90 which was neutral to slightly saline with soil EC ranged 0.02-0.64 dS m-1 that would significantly affect crop production. In the case of the organic carbon, nitrogen and phosphorus content of research area was found to  be low to medium while the range of Potassium was sufficient ranging from 176.34 to 271.77 kg ha1. In these areas recommended fertilizer doses should be applied as per soil test crop response to prevent yield losses due to deficiency of nutrients.
MOVIMENTAÇÃO NO ENSINO DO ESPANHOL EM ESCOLAS PÚBLICAS DE FLORIANÓPOLIS-SC (2003-2013-2020)
Authors: Faggion Bergmann Juliana Cristina , Cesco Andréa , Moreno da Silva Camila
Published: June 2023

O ensino da língua espanhola ainda é um desafio nas escolas brasileiras, apesar de ser a língua falada na maioria dos países da América do Sul. Políticas públicas atuais, como a lei 13.415, de 2017, revogaram a lei de oferta no ensino médio (Lei 11.161, de 2005) e, consequentemente, a disciplina enfrenta novos desafios. Frente a isso, no sentido de contrastar dados compilados, de 2003 e 2013 (BERGMANN, CESCO, 2014), apresentamos, através de pesquisa quantitativa no Censo Escolar, dados de 2020, comparando-os com anteriores para, através deles, mapear a dinâmica da oferta do ensino de ELE nas escolas básicas das redes públicas no município de Florianópolis/SC e a sua relevância para o setor do turismo. Como resultados, percebeu-se uma diminuição da oferta em escolas estaduais e um incremento nas escolas municipais, assim como um aumento de turistas hispanofalantes.
ST-Segment Elevation Followed by de Winter Electrocardiogram Pattern in a Patient With Chest Pain
Authors: Guo Jincheng , Li Zixuan , Wu Yongxia
Published: June 2023

This case report describes a patient in their 40s with no history of cardiovascular disease who presented to the emergency department with chest pain accompanied by sweating.
Photo‐Responsive Azobenzene‐Containing Inverse Opal Films for Information Security
Authors: Yang Xiaoyan , Jin Haibao , Tao Xinfeng , Yao Yuan , Xie Yufeng , Lin Shaoliang
Published: June 2023

Stimuli‐responsive photonic crystals (PCs) have attracted increasing attentions owing to the unique optical feature in regulating the propagation of light and tunable structural colors in response to external stimuli, emerging application potential on diverse fields. However, the development of stimuli‐responsive PCs with wide visible light range, broad shift of bandgaps, and adjustable responsive rates for counterfeiting remains challenging. Herein, a simple strategy for the preparation of photo‐responsive azobenzene‐containing inverse opal (AzoIO) films is reported. First, azobenzene‐containing composites are generated by filling functional monomers into voids of silica colloids crystals. Followed by the thermal polymerization and subsequent etching, a series of AzoIO films are successfully fabricated with adjustable structural colors in wide visible wavelength. Upon irradiation with linearly polarized visible light (LPVL), a slowly broad blueshift of bandgaps (≈138 nm, 3200 s) is observed due to the anisotropic shrinkage of the periodic PC structures. However, UV light irradiation contributed to a fast broad blueshift of bandgaps (≈131 nm, 10 s), owing to the photoisomerization merit of azobenzene moiety. The proof‐of‐concept study on the applications in light‐modulated multicolored writable paper, encryption films, and fast writing/erasing demonstrated the potential for information security. This work paves an avenue for developing promising optical anti‐counterfeiting materials.
A case report of Williams syndrome with main clinical manifestation of hypercalcemia and gastrointestinal bleeding as the main clinical manifestations, and with an accompanying literature review
Authors: Meng Hong , Jia Yue‐Xin , Yang Hui‐Min , Gao Xin , Li Cha‐Gan‐Hu , Xin Guo‐Yan , Wang Yu‐Min
Published: June 2023

Background

Williams syndrome is an autosomal dominant multisystem disorder caused by a 1.5–1.8 Mb deletion on chromosome 7q11.23. It is characterized by facial deformations, cardiovascular abnormalities, developmental delays, gastrointestinal manifestations, and endocrine disorders.

Case description

A 1‐year‐old child presenting with developmental delays, special facial features, gastrointestinal bleeding, renal calcium deposition, and hypotonia was admitted to the hospital for “hypercalcemia and gastrointestinal bleeding.” Genetic testing showed a deletion mutation in the 7q11.23 region. Currently, the child receiving treatment to promote calcium excretion and rehabilitation training, but hypercalcemia has recurred.

Conclusion

The clinical phenotype of Williams syndrome is complex, and different severities, characterized by developmental delays, facial deformities, cardiovascular abnormalities, gastrointestinal symptoms and endocrine disorders, should be considered in children. The syndrome may require thorough genetic testing for diagnosis and early intervention treatment to improve patient quality of life.
Tumor‐derived proliferative CTCs and CTC clusters predict aggressiveness and early recurrence in hepatocellular carcinoma patients
Authors: Zhao Lina , Song Jinge , Sun Yulin , Ju Qiang , Mu Hong , Dong Xiu , Ding Jing , Liu Yunhe , Wang Xuebing , Sun Liying , Wu Jianxiong , Jiao Yuchen , Lu Shichun , Zhao Xiaohang
Published: June 2023

Background

Circulating tumor cells (CTCs), an indispensable liquid biopsy classifier, can provide extra information for the diagnosis and prognosis of hepatocellular carcinoma (HCC).

Methods

We systematically analyzed the peripheral blood of preoperative HCC patients (n = 270) for CTC number, Ki67 index reflecting the proliferative CTC percentage (PCP), and CTC clusters correlated with the characteristics of malignant HCC tumors.

Results

Driver gene mutations were found with high levels of consistency between CTCs and primary tumors (n = 73). CTC number and PCP were associated with tumor size, microvascular invasion (MVI), presence or absence of multiple tumors, and thrombosis significantly. CTC number and PCP robustly separated patients with and without relapse, with a sensitivity of 88.89%/81.48% and a specificity of 72.73%/94.81% in the training set (n = 104) and corresponding values of 80.00%/86.67% and 78.38%/89.19% in the validation set (n = 52), showing a better performance than that associated with the alpha‐fetoprotein (AFP) level. CTC number, PCP, CTC clusters, and MVI were independent significant risk factors for HCC recurrence (P = 0.0375, P < 0.0001, P = 0.0017, and P = 0.0157). A nomogram model based on these risk factors showed a considerable prediction ability for HCC recurrence (area under the curve = 0.947). PCP (training: log‐rank P < 0.0001; hazard ratio [HR] 30.13, 95% confidence interval [CI] = 11.12–81.62; validation: log‐rank P < 0.0001; HR 25.73, 95% CI = 5.28–106.60) and CTC clusters (training: log‐rank P < 0.0001; HR 17.34, 95% CI = 7.46–40.30; validation: log‐rank P < 0.0001; HR 9.92, 95% CI = 2.55–38.58) were more significantly correlated with worse recurrence‐free survival than CTC number (training: log‐rank P < 0.0001; HR 14.93, 95% CI = 4.48–49.78; validation: log‐rank P = 0.0007; HR 9.03, 95% CI = 2.53–32.24).

Conclusion

PCP and CTC clusters may predict HCC recurrence and improve the performance of the serum biomarker AFP.
Combined SEPT9 and BMP3 methylation in plasma for colorectal cancer early detection and screening in a Brazilian population
Authors: Lima Adhara Brandão , dos Reis Mariana Bisarro , Matsushita Marcus , dos Reis Monise Tadin , de Oliveira Marco Antônio , Reis Rui Manuel , Guimarães Denise Peixoto
Published: June 2023

Background

Colorectal cancer (CRC) screening can help to reduce its incidence and mortality. Noninvasive strategies, such as plasma analysis of epigenetic alterations, can constitute important biomarkers of CRC detection.

Objective

This study aimed to evaluate the plasma methylation status of SEPT9 and BMP3 promoters as biomarkers for detection of CRC and its precursor lesions in a Brazilian population.

Methods

Plasma samples from 262 participants of the CRC screening program of Barretos Cancer Hospital who had a positive fecal occult blood test and underwent colonoscopy and cancer patients were analyzed. Participants were grouped according to the worst lesion detected in the colonoscopy. Cell‐free circulating DNA (cfDNA) was bisulfite treated followed by the analysis of SEPT9 and BMP3 methylation status using a droplet digital PCR system (ddPCR). The best methylation cutoff value for group discrimination was calculated by receiver operating characteristic (ROC) curve analysis.

Results

Among the 262 participants, 38 were diagnosed with CRC, 46 with advanced adenomas 119 with nonadvanced adenomas, three with sessile serrated lesions, and 13 with hyperplastic polyps. In 43 participants, no lesion was detected in the colonoscopy and were used as controls. The CRC group showed the highest cfDNA concentration (10.4 ng/mL). For the SEPT9 gene, a cutoff of 2.5% (AUC = 0.681) that discriminates between CRC and the control group resulted in CRC sensitivity and specificity of 50% and 90%, respectively. Concerning the BMP3 gene, a cutoff of 2.3% (AUC = 0.576) showed 40% and 90% of sensitivity and specificity for CRC detection, respectively. Combining SEPT9, BMP3 status, and age over 60 years resulted in a better performance for detecting CRC (AUC = 0.845) than the individual gene models, yielding 80% and 81% of sensitivity and specificity, respectively.

Conclusion

The present study suggests that a combination of SEPT9 and BMP3 plasma methylation, along with age over 60 years, showed the highest performance in detecting CRC in a Brazilian population. These noninvasive biomarkers can potentially serve as useful tools for CRC screening programs.
Improvement in persistent idiopathic facial pain with comorbid ADHD using the combination of a dopamine system stabilizer and psychostimulant: A case report
Authors: Kasahara Satoshi , Kato Yuichi , Takahashi Kaori , Matsudaira Ko , Sato Naoko , Fukuda Ken‐Ichi , Toyofuku Akira , Niwa Shin‐Ichi , Uchida Kanji
Published: June 2023

Key Clinical Message

Persistent idiopathic facial pain (PIFP) and attention‐deficit/hyperactivity disorder (ADHD) may coexist and can be improved with ADHD medications. Thus, clinicians should screen for ADHD by a multidisciplinary approach when treating PIFP and differentiate between other odontogenic disorders.

We report a case of a woman with persistent idiopathic facial pain (PIFP) and attention‐deficit/hyperactivity disorder (ADHD) that markedly improved with the administration of a combination of aripiprazole (APZ) and methylphenidate (MP) treatment. Screening for ADHD and administration of APZ and/or MP may be considered in treating PIFP.
Mononeuropathy multiplex as an uncommon presentation of intravascular lymphoma: A case report
Authors: Haqi‐Ashtiani Bahram , Moghaddam Parichehr , Barzkar Farzaneh , Zare Mehrjerdi Ali , Almasi‐Dooghaee Mostafa
Published: June 2023

Key Clinical Message

Although intravascular lymphoma rarely presents with peripheral neuropathy, learning about this presentation can lead to timely diagnosis and improved prognosis in patients with intravascular lymphoma.

A 64‐year‐old man presented with asymmetric paresthesia and subsequent weakness of his feet and a 10 kg weight loss over 40 days. Electrodiagnostic studies revealed distal axonal sensory‐motor polyneuropathy with ongoing axonal loss. A peroneal nerve biopsy showed intravascular proliferation of CD‐20 positive lymphocytes, which suggested intravascular large B‐cell lymphoma.
Adversarial autoencoder concurrent projection to latent structure and its application
Authors: Liu Dongyu , Zhou Jinglin , Jiang Huixia
Published: June 2023

Multivariate monitoring plays an important role in process monitoring. Among the multivariate monitoring methods, the projection to latent structure method (PLS) has been most widely used in the fields of quality control and fault diagnosis. To improve the monitoring capability of traditional PLS methods in nonlinear and non‐Gaussian multivariate systems, this paper proposes an innovative multivariate monitoring strategy, which combines adversarial autoencoder (AAE) and the concurrent projection to latent structure method (CPLS). In the proposed strategy, the original data are mapped to the high‐dimensional space using the AAE method with the Gaussian prior distribution to realize data transformation. The mapped data are linearly divisible and approach the Gaussian distribution. Then, the projection with orthogonality is realized using the CPLS method. In addition, the reconstruction error and distribution properties are used as evaluation indexes of the high‐dimensional mapping performance. The corresponding monitoring strategy is established using the traditional statistical method based on the Gaussian distribution. Finally, the simulations are performed on the Tennessee‐Eastman process platform, and the results show that the proposed method could efficiently extract the principal components, especially in quality‐relevant fault monitoring.
A single CCII‐based high‐precision voltage‐mode full‐wave rectifier suitable for low‐level signals
Authors: Yucehan Tolga , Yuce Erkan , Minaei Shahram
Published: June 2023

A new second‐generation current conveyor‐based full‐wave rectifier (FWR) is proposed in this work. The proposed voltage‐mode FWR comprises a single active building block, four diodes, and three grounded resistors without needing any passive element matching problems. It does not suffer from any bias voltages and/or currents; therefore, it does not need extra circuitry. It can simultaneously provide positive and negative rectifications; thus, it is flexible. The proposed FWR has high input impedance; accordingly, it can be easily cascadable. Several simulations via the SPICE program and some experiments by using the AD844s are achieved. 0.18‐μm TSMC CMOS technology parameters are used in the simulations.
Trans‐ethnic polygenic risk scores for body mass index: An international hundred K+ cohorts consortium study
Authors: Qu Hui‐Qi , Connolly John J , Kraft Peter , Long Jirong , Pereira Alexandre , Flatley Christopher , Turman Constance , Prins Bram , Mentch Frank , Lotufo Paulo A , Magnus Per , Stampfer Meir J , Tamimi Rulla , Eliassen A Heather , Zheng Wei , Knudsen Gun Peggy Stromstad , Helgeland Oyvind , Butterworth Adam S. , Hakonarson Hakon , Sleiman Patrick M. ,   the IHCC consortium
Published: June 2023

Background

While polygenic risk scores hold significant promise in estimating an individual's risk of developing a complex trait such as obesity, their application in the clinic has, to date, been limited by a lack of data from non‐European populations. As a collaboration model of the International Hundred K+ Cohorts Consortium (IHCC), we endeavored to develop a globally applicable trans‐ethnic PRS for body mass index (BMI) through this relatively new international effort.

Methods

The polygenic risk score (PRS) model was developed, trained and tested at the Center for Applied Genomics (CAG) of The Children's Hospital of Philadelphia (CHOP) based on a BMI meta‐analysis from the GIANT consortium. The validated PRS models were subsequently disseminated to the participating sites. Scores were generated by each site locally on their cohorts and summary statistics returned to CAG for final analysis.

Results

We show that in the absence of a well powered trans‐ethnic GWAS from which to derive marker SNPs and effect estimates for PRS, trans‐ethnic scores can be generated from European ancestry GWAS using Bayesian approaches such as LDpred, by adjusting the summary statistics using trans‐ethnic linkage disequilibrium reference panels. The ported trans‐ethnic scores outperform population specific‐PRS across all non‐European ancestry populations investigated including East Asians and three‐way admixed Brazilian cohort.

Conclusions

Here we show that for a truly polygenic trait such as BMI adjusting the summary statistics of a well powered European ancestry study using trans‐ethnic LD reference results in a score that is predictive across a range of ancestries including East Asians and three‐way admixed Brazilians.
A network analysis of disordered eating symptoms, big‐five personality traits, and psychological distress in Chinese adults
Authors: Liang Guangsheng , Cheng Yawei , Barnhart Wesley R. , Song Jianwen , Lu Tom , He Jinbo
Published: June 2023

Objective

Previous studies have revealed associations between disordered eating symptoms, big‐five personality traits, and psychological distress. However, limited research has explored these relationships as a network, including their interconnections, and even less has done so in non‐Western populations. We employed network analysis to investigate the co‐occurrence of disordered eating symptoms, big‐five personality traits, and psychological distress in Chinese adults.

Method

A sample of 500 Chinese adults (256 men) completed measures assessing big‐five personality traits, psychological distress, and disordered eating symptoms. The network of personality traits, psychological distress, and disordered eating symptoms was estimated, including its central and bridge nodes.

Results

The central nodes in the network were the facets of openness (like adventure), extraversion (like going to social and recreational parties), and disordered eating symptoms (dissatisfaction with body weight or shape). Moreover, certain facets of neuroticism (always worrying something bad will happen), psychological distress (feeling worthless), and an inverse facet of extraversion (bored by parties with lots of people) were identified as essential bridge nodes in maintaining the structure of the network.

Conclusion

Our findings suggest that personality traits (e.g., openness and extraversion) and body dissatisfaction are important in maintaining the network in a community sample of Chinese adults. While future replication is needed, findings from this study suggest that individuals with negative self‐thinking, predisposed neuroticism, and extraversion may be at risk of developing disordered eating symptoms.

Public Significance

The present study contributes to existing knowledge by employing a network perspective to examine the associations between disordered eating symptoms, big‐five personality traits, and psychological distress in a Chinese adult community sample. The identified facets of neuroticism and extraversion and symptoms of psychological distress may be worthy of targeting in the prevention and treatment of disordered eating in the Chinese context.
Effect of annular ribs in heat exchanger tubes on the performance of phase‐change regenerative heat exchangers
Authors: Zhu Chuanhui , Lin Zhehao , Liu Wei , Liu Qian , Yan Shubin
Published: June 2023

Optimizing the efficiency of conventional heat exchangers is critical for improving the performance of various processes. This study proposed increasing the heat dissipation buffer space of heat exchangers by filling the gap between the heat exchanger and the shell with phase‐change materials for optimizing phase‐change heat exchangers. Comparative simulation analyses were performed by investigating the difference between the internal and external diameters of the inner ring ribs of the heat exchanger, the flow rate of the cooling liquid, the spacing distance, and the number of the inner ring ribs as independent variables. The results revealed that the heat transfer efficiency of heat exchangers can be improved by adding the inner ring rib structure to the heat exchange copper tube. The difference between the inner and outer diameters of the inner ring rib considerably influences heat dissipation. Furthermore, a sensitivity coefficient of 0.2457 can be obtained. The distance and number of inner ring ribs and the flow rate of cooling liquid exhibit certain effects on the heat transfer efficiency of the heat exchanger. The sensitivity coefficients were 0.1477 and 0.0935. The heat dissipation efficiency of the coil heat exchanger was improved by 3.8% by adding inner ring ribs in the coil heat exchanger channel.
SOH estimation and RUL prediction of lithium batteries based on multidomain feature fusion and CatBoost model
Authors: Zhang Mei , Yin Jun , Chen Wanli
Published: June 2023

In this paper, a lithium‐ion battery State of Health (SOH) estimation algorithm is proposed based on the fusion of multidomain features and the application of a CatBoost model. The aim is to address the issue of low prediction accuracy in SOH caused by the utilization of single‐feature extraction techniques. The algorithm encompasses the extraction of various features from the original charge–discharge data, including time‐domain, frequency‐domain, entropy, and time‐series features. Following the evaluation of feature importance, a feature selection process is conducted to eliminate redundant features that provide a limited contribution to the predictive results. Subsequently, a multiple‐set discriminative correlation analysis is employed to integrate high‐dimensional features. To attain accurate predictions, the CatBoost model is further optimized through the utilization of a sparrow search algorithm. Experimental results demonstrate that the proposed algorithm achieves accurate SOH estimations within individual batteries, as evidenced by mean square error values consistently below 4e−4 and goodness‐of‐fit values exceeding or equal to 0.98. Additionally, the algorithm exhibits reliable prediction capabilities across different batteries operating under the same charge/discharge strategy. Comparative analysis indicates that the adoption of the multidomain feature fusion approach yields improved prediction accuracy in contrast to the utilization of a single feature extraction method.
Longitudinal associations of bioelectrical phase angle and fatigue in breast cancer patients
Authors: Schmidt Martina E. , Chong Marvin , Klassen Oliver , Wiskemann Joachim , Steindorf Karen
Published: June 2023

Cancer‐related fatigue is commonly treated in an undifferentiated manner, because its pathophysiology is still not well understood. Therefore, we investigated if bioelectrical phase angle (PhA), a non‐invasive marker of cell integrity, could help to single out specific fatigue subtypes. In a randomized controlled strength training intervention trial, PhA was measured by bioelectrical impedance analysis in 158 breast cancer patients. Fatigue was assessed with the multidimensional 20‐item Fatigue Assessment Questionnaire. Multiple regression analyses considering changes in PhA and fatigue from baseline to post‐intervention and ANCOVA models investigating the strength training effect on PhA were conducted. Further, explorative mediation and moderation analyses were performed. Decrease (=worsening) in PhA was significantly associated with increase in physical (P = .010) and emotional (P = .019) fatigue. These associations were markedly stronger in patients with normal BMI (interaction P = .059 and .097) and with low pre‐diagnosis exercise level (interaction P = .058 and .19). Among patients with normal BMI strength training was associated with an increase in PhA (ANCOVA P = .059), but not among overweight/obese patients (interaction P = .035). Chemotherapy was a major determinant for low PhA, but PhA did not mediate the effect of chemotherapy on fatigue. In conclusion, PhA has a significant inverse association with physical and emotional fatigue. This association is moderated by BMI and previous exercise. Significant relationships of PhA were also observed with chemotherapy and strength training. Thus, PhA might be a marker that could help in the classification of subtypes of fatigue with different pathophysiology, which may require specifically tailored treatment. Further research on this is warranted.
Coupling men‐to‐women: Promoting innovation in emerging markets
Authors: Machokoto Michael , Lemma Tesfaye T. , Dsouli Ouarda , Fakoussa Rebecca , Igudia Eghosa
Published: June 2023

Motivated by calls to explore corporate outcomes of gender diversity‐related dependencies in a firm's upper echelons, we examine whether gender diversity in manager‐owner(s) teams shapes innovation. Using the context of emerging markets and a large surveydataset drawn from the Business Environment and Enterprise Performance Survey (BEEPS), we find robust evidence suggesting that gender‐diverse manager‐owner(s) teams are associated with higher odds of undertaking innovation. Specifically, women (men) owned firms managed by a male (female) top manager are associated with a higher likelihood of undertaking innovation relative to women (men) owned firms managed by women (men). Additionally, we find that female‐owned firms run by male (female) top managers are the most (least) innovative and male‐owned firms run by female (male) top managers are the second (third) innovative. Our findings indicate that heterophilic manager‐owner(s) teams have the potential to foster innovation in emerging markets. More importantly, our results suggest that initiatives promoting manager‐owner(s) team's gender diversity have the potential to overcome the social and structural barriers that impede innovation in emerging economies.
Why has plasma exchange failed in TRACK syndrome? Lessons from a new variant of the atypical hemolytic uremic syndrome
Authors: Durak Cansu , Sahin Ebru Guney , Yusuf Can Yasar , Varol Fatih , Cam Halit
Published: June 2023

Atypical hemolytic uremic syndrome (aHUS) is a rare and life‐threatening form of thrombotic microangiopathy, associated with high mortality and morbidity. Most cases present with hemolytic anemia, thrombocytopenia, and renal insufficiency. However, it can have unusual multiple end‐organ injuries including extrarenal organ and system involvements such as neurologic, cardiac, gastrointestinal, and respiratory systems. We describe a 4‐year‐old girl who developed aHUS due to the TSEN2 mutation and had cardiac involvement. She did not benefit from plasma exchange, as stated in previous cases. It should be kept in mind that therapeutic plasma exchange may not be beneficial in some cases of aHUS, especially due to genetic mutations.