bluuebunny/crossref_metadata_2025 huggingface dataset:
A case of septic pulmonary embolism associated with hand sepsis in an immunocompetent host
Authors: Zobair T , Sihlahla I , Arnolds D B , Raine R I , Calligaro G
Published: July 2024

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Tracheobronchial foreign body aspiration in children in Soweto, South Africa: A retrospective descriptive study
Authors: Moola A , Verwey C , Mabaso T , Mopeli K , Withers A , Loveland J , Patel N , Dangor Z
Published: July 2024

Background. Airway foreign bodies are a common cause of accidental death in children. Tracheobronchial foreign body aspiration (FBA) can result in severe immediate and long-term complications if the foreign body is not identified and removed. Little is known about the burden of tracheobronchial FBA in the Soweto area, south of Johannesburg, South Africa.Objectives. To describe the burden and clinical characteristics of tracheobronchial FBA in hospitalised children in a tertiary-level hospital in Johannesburg.
Methods. This was a retrospective, single-centre, descriptive study of children aged <10 years who presented to Chris Hani Baragwanath Academic Hospital from 1 January 2011 to 31 December 2020. Children with FBA were identified from the paediatric pulmonology and paediatric surgery databases using the relevant International Statistical Classification of Diseases and Related Health Problems, 10th revision (ICD-10), codes (T17.4 and T17.5). Clinical and radiological data were extracted from medical records and the databases.Results. Forty-seven children with FBA were identified during the study period. Overall, the incidence of FBA among children aged <10 years of age was 1.42 per 100 000 person-years (95.0% confidence interval 1.04 - 1.88). FBA occurred more commonly in males (66.0%; n=31), and the mean (standard deviation) age at presentation was 68 (28.2) months. Most of the children (42.6%) were in the 7 - <10-year age group, followed by the 5 - <7-year age group (27.7%). Chronic respiratory symptoms were reported in one-third of the children, and a history of witnessed FBA was reported in only 59.6% of cases. Inorganic foreign bodies (n=29; 61.7%) were aspirated more commonly than organic foreign bodies; these included metal objects such as pins or springs (21.3%), toy parts (17.0%), pen or pencil lids/ stoppers (12.8%) and plastic objects (6.4%).Conclusion. Our study highlights the fact that tracheobronchial FBA is prevalent in school-aged children, and public safety campaigns targeted at this age group are warranted. Furthermore, to prevent sequelae, a high index of suspicion in required in children with respiratory symptoms that fail to respond to appropriate therapy.
The need for smoking cessation counselling and nicotine with- drawal therapy for hospitalised patients: A smoking point preva- lence study at Groote Schuur Hospital, Cape Town, South Africa
Authors: Soin G , Kok J , Allie A , Bhawoodien Q , Dheda K , Geragotellis A , Mulisa K , Sibi A , Tarwa T , Leone F , Van Zyl-Smit R
Published: July 2024

Background. South Africa has high tobacco-attributable mortality and a smoking prevalence of 32.5% in males and 25.6% in females. There are limited data on smoking prevalence and desire to quit in hospitalised patients, who have limited access to smoking cessation services.
Objectives. To determine smoking prevalence and the extent of nicotine withdrawal symptoms, using a hospital-wide inpatient survey.
Methods. A 1-day point prevalence survey was conducted at Groote Schuur Hospital, Cape Town. All wards except the haematology isolation, active labour and psychiatry lock-up wards were evaluated. Smoking status, withdrawal symptoms and desire to quit were established.
Results. Smoking status was confirmed in 85.8% of inpatients (n=501/584), of whom 31.9% (n=160) were current smokers; 43.5% (n=101/232) of male and 21.9% (n=59/269) of female inpatients were smokers. Documentation and confirmation of smoking status was highest in the maternity wards (100%) and lowest in the surgical wards (79.6%) and intensive care units (70.0%). Smoking prevalence ranged from 47.6% in male surgical patients to 15.2% in maternity patients. Of the smokers, 54.5% reported being motivated to quit, with a median (interquartile range) Fagerström test for nicotine dependence score of 4 (2 - 6), and 31.4% reported moderate to severe cravings to smoke, highest in the surgical wards.
Conclusion. Smoking prevalence was higher in hospitalised patients than in the local general population. Many inpatients were not interested in quitting; however, a third had significant nicotine withdrawal symptoms. All inpatients who are active smokers should be identified and given universal brief smoking cessation advice. Patients with severe withdrawal symptoms should be allowed to smoke outside, and nicotine withdrawal pharmacotherapy should be provided to those who are bedbound or express a desire to stop smoking during the current admission.
Tracheal necrosis after sandwich immunotherapy and stereotactic body radiotherapy for lung cancer
Authors: Bennji S M , Jayakrishnan B , Al- Hashami Z , Mula-Hussain L , Telugu R B
Published: July 2024

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A contract law approach to private censorship of art on social media platforms
Authors: Melian Pérez Gabriel Ernesto , El-Mecky Nausikaä
Published: July 2024

The censorship of artists on social media impacts their freedom of expression and their ability to monetize and engage with their audiences. Furthermore, this fosters a process of cultural standardization. Several legal arguments have been raised against art censorship in social media platforms, mainly based on public law, however, they are not effective in all jurisdictions, as demonstrated by U.S. case law. The purpose of this paper is to shift the spotlight and provide solutions from a private law perspective, specifically from contract law. The main argument here is that courts should abandon their traditional bilateral/vertical approach and embrace a more nuanced one that better reflects the complexity of the relationships taking place in social media. This would give those affected access to concrete contractual remedies and allow for greater control over the content moderation process.
Influence of informational and psychological impact of mass media on the formation of spiritual and moral values among police cadets
Authors: Kipreev Sergei Nikolaevich
Published: July 2024

The author considers the specifics of the influence of mass media on the process of formation of spiritual and moral values among students of educational organizations of the Ministry of Internal Affairs of Russia. The special role of patriotic education and its interrelation with the process of formation of spiritual and moral values among police cadets is shown. Arguments are given about the importance of protecting law enforcement officers from negative information impact in a globalizing world. The object is cadets of educational organizations of the Ministry of Internal Affairs of Russia. The subject of the article is the peculiarities of the informational and psychological impact of the media on the spiritual and moral sphere of a person's personality. The author considers in detail such important aspects of the topic under study as the ability of police officers to counteract the negative influence of the media in a modern digital society, the main areas of media influence on the personality of police officers, the ability of cadets to form a system of spiritual and moral values. The author proves the thesis that the developed spiritual and moral values of cadets are a necessary barrier to the threats of the modern globalizing world. The novelty and relevance of the research are due to the complicated socio-political situation in the world and the need for additional research that opens up new mechanisms of information and psychological impact of mass media on the spiritual and moral sphere of the individual. The researcher comes to the conclusion that in order to ensure reliable protection of police officers from the negative impact of the media, it is necessary to block hostile media-foreign agents, increase the intensity of the pedagogical impact of the educational organization system and work on leveling the negative informational and psychological impact of the media.
PITAR, a DNA damage-inducible Cancer/Testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA
Authors: Jana Samarjit , Mondal Mainak , Mahale Sagar , Gupta Bhavana , Prasasvi Kaval Reddy , Kandasami Lekha , Jha Neha , Chowdhury Abhishek , Santosh Vani , Kanduri Chandrasekhar , Somasundaram Kumaravel
Published: July 2024

In tumors with WT p53, alternate mechanisms of p53 inactivation are reported. Here, we have identified a long noncoding RNA, PITAR (
p
53
I
nactivating
T
RIM28
a
ssociated
R
NA), as an inhibitor of p53. PITAR is an oncogenic Cancer/testis lncRNA and is highly expressed in glioblastoma (GBM) and glioma stem-like cells (GSC). We establish that TRIM28 mRNA, which encodes a p53-specific E3 ubiquitin ligase, is a direct target of PITAR. PITAR interaction with TRIM28 RNA stabilized TRIM28 mRNA, which resulted in increased TRIM28 protein levels and reduced p53 steady-state levels due to enhanced p53 ubiquitination. DNA damage activated PITAR, in addition to p53, in a p53-independent manner, thus creating an incoherent feedforward loop to inhibit the DNA damage response by p53. While PITAR silencing inhibited the growth of WT p53 containing GSCs in vitro and reduced glioma tumor growth in vivo, its overexpression enhanced the tumor growth in a TRIM28-dependent manner and promoted resistance to Temozolomide. Thus, we establish an alternate way of p53 inactivation by PITAR, which maintains low p53 levels in normal cells and attenuates the DNA damage response by p53. Finally, we propose PITAR as a potential GBM therapeutic target.
LPS-induced systemic inflammation is suppressed by the PDZ motif peptide of ZO-1 via regulation of macrophage M1/M2 polarization
Authors: Lee Hyun-Chae , Park Sun-Hee , Jeong Hye Min , Shin Goeun , Lim Sung In , Kim Jeongtae , Shim Jaewon , Park Yeong-Min , Song Kyoung Seob
Published: July 2024

The gram-negative bacterium lipopolysaccharide (LPS) is frequently administered to generate models of systemic inflammation. In particular, both kidney and lung are more sensitive to acute injury caused by LPS-induced systemic inflammation. However, there are several side effects and no effective treatment for LPS-induced systemic inflammation. PEGylated PDZ peptide was based on the first PDZ domain of the zonula occludens-1 (ZO-1) protein. PEGylated PDZ peptide was analyzed for effects on systemic inflammation induced by LPS. PDZ peptide administration led to restoration of tissue injuries (kidney, liver, and lung) and prevented alterations in biochemical plasma markers. The production of pro-inflammatory cytokines was significantly decreased in the plasma and lung BALF in the PDZ-administered mice. Flow cytometry analysis revealed the PDZ peptide significantly inhibited inflammation, mainly by decreasing the population of M1 macrophages, neutrophils (immature and mature), and increasing M2 macrophages. Using RNA sequencing analysis, the expression levels of the NF-κB-related proteins were lower in PDZ-treated cells than in LPS-treated cells. In addition, wild-type PDZ peptide significantly increased mitochondrial membrane integrity and decreased LPS-induced mitochondria fission. Interestingly, PDZ peptide dramatically could reduce LPS-induced NF-κB signaling, ROS production, and the expression of M1 macrophage marker proteins, but increased the expression of M2 macrophage marker proteins. These results indicated that PEGylated PDZ peptide inhibits LPS-induced systemic inflammation, reducing tissue injuries and reestablishing homeostasis and may be a therapeutic candidate against systemic inflammation.
Brazilin cream from Caesalpinia sappan inhibit periodontal disease: in vivo study
Authors: Sugiaman Vinna Kurniawati , Jeffrey Jeffrey , Naliani Silvia , Pranata Natallia , Lelyana Shelly , Widowati Wahyu , Ferdiansyah Rival , Hadiprasetyo Dhanar Septyawan , Ayuni Vini
Published: July 2024

Background

Gingivitis is an inflammation of the gums that is the initial cause of the development of periodontal disease by the activity of Nuclear Factor-kappa B (NF-κB), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), p38, and Tumor Necrosis Factor-α (TNF-α). Unaddressed chronic inflammation can lead to persistent disturbances in other parts of the body. Brazilin is a naturally occurring plant chemical that may have antibacterial and anti-inflammatory effects. Treatment based on the natural plant compound, brazilin, is developed in the form of a topical cream for easy application.

Objective

The aim is to develop the natural compound brazilin in the form of a topical cream as an anti-inflammatory agent to reduce NF-κB expression through Imunohistochemistry (IHC) methods, and the expression of pro-inflammatory genes IL-1β, IL-6, p38, and TNF-α.

Methods

Male Sprague-Dawley rats were induced with gingivitis using P. gingivalis bacteria. The observed groups included rats treated with a single application of brazilin cream and rats treated with two applications of brazilin cream. The treatment was administered for 15 days. On days 3, 6, 9, 12, and 15, anatomical wound observations and wound histology using hematoxylin-eosin and Masson’s Trichrome staining were performed. NF-κB protein expression was analyzed using the IHC method. Gingival inflammation gene expression of NF-κB, IL-1β, IL-6, p38, and TNF-α was measured using q-RTPCR.

Results

Single and double applications of brazilin cream increased angiogenesis and decreased NF-κB protein expression, in addition to the IL-1β, IL-6, p38, and TNF-α gene expressions.

Conclusion

In a rat gingivitis model, Brazilin cream may function as an anti-inflammatory agent in the gingival tissue.
Comparison of perceived masticatory ability in completely edentulous patients treated with thermoplastic complete denture versus single implant-retained mandibular overdenture: a single-center prospective observational study
Authors: Fayad Mostafa I. , Mahmoud Ihab I. , Aly Shon Ahmed Atef , Elboraey Mohamed Omar , Bakr Ramy M. , Moussa Rania
Published: July 2024

Background

This study aimed to compare the perceived masticatory ability (PrMA) in completely edentulous patients (EDPs) with thermoplastic conventional complete dentures (CDs) versus single implant-retained mandibular overdentures.

Methods

The current study was conducted in the outpatient Prosthodontic Clinic, Faculty of Dental Medicine, Al-Azhar University, Cairo, Egypt. PrMA was evaluated in 45 completely edentulous patients (46% males, mean age 50.4 ± 4.7 years). Each patient received a thermoplastic PMMA complete denture (Polyan IC TM Bredent GmbH & Co.KG, Germany). The PrMA was evaluated at one-month and six-month intervals of denture use. An immediate loading single implant was placed into the mid-symphyseal for each patient, and the denture was adjusted. Subsequently, the PrMA was reevaluated after one month and six months. The data were collected and statistically analyzed using the SPSS@V25 to assess the changes in PrMA.

Results

The PrMA demonstrated improvement after six months of thermoplastic conventional denture use. However, this improvement was not statistically significant (p = 0.405). In addition, the PrMA showed a substantial increase following a single implant placement at one and six months (p < 0.001) of the overdenture use compared to the conventional denture. The PrMA insignificantly improved (p = 0.397) after six months of the single implant retained overdenture use.

Discussion

The study’s findings indicate that using immediate loading single implant-retained mandibular overdentures significantly improved PrMA in completely edentulous patients.
Biodiversity and Ichthyofaunal Richness of Fish Population in River Subansiri in the Downstream of the Lower Subansiri Hydro-electric Power Project Dam, Assam, India
Authors: Hussain Imran , Ali Ayub , Ahmed Imtiaz , Gogoi Rinku , Sarma Jiten , Dutta Rajdeep , Chintey Sheetala
Published: July 2024

The present study on fish diversity, assemblages, water quality and conservation status of Subansiri river, Assam was conducted for a period of one year in the mainstream. Altogether 55 fish species belonging to 42 genera, 24 families and 10 orders were recorded from the river. The largest group Cypriniformes contributed 3 families (12.50%), 15 genera (35.71%) and 20 species (36.36%). As per IUCN conservation status, 51 (92.72%) species were recorded as Least Concern, 2 (3.64%) species under near threatened, 1 (1.82%) species under vulnerable and 1 (1.82%) species under endangered category. The mean value with regard to Physico-chemical parameters of river Subansiri was moderate. The Bray-Curtis similarity prepared for river Subansiri showed the highest similarity between stations 2 and 3 in the pre-monsoon season. The CCA analysis indicates that alkalinity, TDS, temperature, conductivity, pH, dissolved oxygen, transparency and velocity are the most important parameters influencing the fish distribution and assemblage in the river.
Chemical Communication between Male and Female Sex of Bombyx mori
Authors: Rajkhowa Abhigyan , Saikia Monimala , Brahma Dipankar , Bora Nilav Ranjan , Saikia Rimpi Rani , Dutta Pankaj Lushan , Nath Indrani
Published: July 2024

Communication involves the systematic and symbolic exchange of information between entities. In insects, the most significant form of communication occurs between members of the same species. Silkworms primarily utilize pheromones for communication. Bombykol, the sex pheromone released by the female silk moth Bombyx mori, was first extracted by Adolf Butenandt. The biosynthesis of bombykol occurs in the pheromone gland, where various enzymes and genes participate in the biosynthesis process through an influx of extracellular Ca2+. Bombykol-sensitive ORNs are located on the antennae of male moths, which perceive the bombykol released by female moths. These ORNs are so sensitive that even a single pheromone molecule can generate an electric signal in the male moth. Once the male moth detects the bombykol molecule, the Pheromone Binding Protein plays a crucial role in enabling it to bind to the receptor without disruption. Mori, B. The substance is rapidly eliminated from its receptor site and rendered inactive by phenomenol-degrading enzymes and alcohol oxidase genes. Numerous studies and tests conducted on B. mori's sex pheromone have yielded important insights into the molecular and genetic aspects for the chemical interactions with male and female silkworms, which including the synthesis, behavioral reaction, and the perception of bombykol.
Social Collaboration System and Structural Demeanor of Public Elementary School Teachers
Authors: Ferrando Real Rose T. , Baguio Josephine B.
Published: July 2024

This study determined and described the social collaboration system and structural demeanor of public elementary school teachers in Mati City Division, Davao Oriental. The research employed a non-experimental quantitative research design utilizing the correlational method. The respondents consisted of 139 teachers from public elementary schools selected through universal sampling. Data analysis involved mean calculations, Pearson correlation coefficient (r), and regression analysis. The findings revealed that the social collaboration system among public elementary school teachers, particularly in terms of teamwork, partnership, and networking, was frequently manifested. Additionally, the structural demeanor of these teachers, including performance, communication, motivation, and leadership, was often demonstrated. Importantly, the study found a significant relationship between the social collaboration system and the structural demeanor of public elementary school teachers. Specifically, it was found that the domains of the social collaboration system significantly influence the structural demeanor of teachers in Mati City Division, Davao Oriental. Based on these findings, it is recommended that public school teachers participate in symposia and training programs organized by the Department of Education (DepEd) for professional development. This approach aims to enhance teachers' skills and capacities, thereby improving educational opportunities for students and promoting the adoption of effective educational practices.
The Role of Headteachers Administrative Experience on Instruction Supervision in Kwale County, Kenya
Authors: A., N Mwanarusi, , N Thuo, D.,
Published: July 2024

Students' academic success is influenced by a variety of factors, one of which is the instructional supervisory tasks played by headteachers. The study's goal was to ascertain how the headteachers experience in administration affected their instructional supervisory roles in public primary schools in Kwale County, Kenya. The objective of the study was to determine how headteachers’ administrative experience in administration affect their instructional supervisory roles in public primary schools in Kwale County, Kenya. The study adopted descriptive research design which involved the use of qualitative research approach. The study's target audience consisted of all 432 public primary school headteachers in Kwale County, Kenya. The sample size consisted of 201 headteachers who were chosen at random from Kwale County's public primary schools. Based on propositional representation of the schools in each sub-county, the sample size was selected from all five sub-counties. Headteachers were surveyed in order to gather statistics. To determine the validity and reliability of the instrument, pilot research involving ten head teachers from ten public primary schools in the nearby Kilifi County was carried out. Reliability was determined by using test- retest method. The second test was given to the same respondents who did the first test after one week. The data collected during the two tests of the pilot study was used to compute reliability coefficient. A reliability coefficient of r= .78 was obtained. Validity was ascertained through expert judgement of the items in the questionnaire. Frequencies and percentages were used to analyze qualitative data descriptively, and the results were displayed in tables, charts, and percentage graphs. Version 23 of the Statistical Packages for Social Sciences (SPSS) was used to conduct the analysis, which was then displayed using tables. The research finding showed that, high average percentage of headteachers' strongly agreed or agreed that the headteachers' experience in administration affect  they carry out their instructional supervisory role in public primary schools in Kwale county, Kenya.The results of the study can be applied to enhance instructional monitoring in Kenya's Kwale County public primary schools.
Anti-inflammatory Property of Methanolic Extract of Zanthoxylum leprieurii Guill. & Perr. Root Bark
Authors: Ugboma Evaristus J. , Eze Fabian I. , Amaechi Victor C.
Published: July 2024

Purpose: The purpose of this study was to assess the phytochemical composition and anti-inflammatory effects of an aqueous methanolic extract derived from the root bark of Zanthoxylum leprieurii, a tropical plant used traditionally in the treatment of inflammation in Nigeria.
Methods: Preliminary phytochemical screening of the aqueous-methanol extract of the root bark of Zanthoxylum leprieurii was done to determine the main secondary metabolites. The anti-inflammatory activity of the crude extract of zanthoxylum leprieurii root back was determined using the egg albumin-induced model of inflammation, and the results were analyzed using a one-way ANOVA and student t-test.
Results: The yield after extraction was 25g. The phytochemical screening indicates the presence of the following metabolites: tannins, flavonoids, alkaloids, and saponins. The paw edema inhibition percentages at the 3rd and 4th hours were 14.8% and 46.3% for the 200 mg/kg dose, and 26.5% and 70.3% for the 400 mg/kg dose, respectively.
Conclusion: The result of the in vivo anti-inflammatory evaluation carried out showed statistical significance and therefore justified the folkloric uses of the plant as an anti-inflammatory agent.
Revitalizing Rainfed Agriculture: The Transformative Potential of Watershed Development
Authors: Saharan Sachin , Singh Janardan , Sharma Rahul , Singh Akshay , Narwal Kunal , Rana Bharat Bhushan , Kumari Saroj , Prashar Divya
Published: July 2024

Out of the 1.5 billion ha (11% of the world’s land surface of 13.4 billion ha) of cropland worldwide, 1.20 (80%) billion ha is rainfed, and 60 percent of the world’s food comes from rainfed areas.  In India, rainfed agriculture occupies about 51 percent of the country’s net sown area and accounts for nearly 40 percent of the total food production.  In HP, over 10% area of the state is under cultivation, of which about 81% is rainfed, facing frequent water scarcity.  Watershed development constitutes a holistic strategy aimed at enhancing the resilience and productivity of rainfed farming systems.  This approach integrates various interventions targeting soil and water conservation, afforestation, agricultural practices, and socio-economic empowerment of local communities.  The essence of watershed development lies in its comprehensive and participatory nature, which addresses the complex interactions among hydrological, ecological, and socio-economic factors influencing rainfed agriculture.  Through the implementation of watershed management techniques, such as contour bunding, check dams and afforestation, soil erosion is minimized, water resources are conserved, and micro-climatic conditions are ameliorated.  Concurrently, sustainable agricultural practices, including agroforestry, conservation agriculture, and water harvesting techniques, are promoted to enhance farm productivity and diversify livelihood options for farmers.  Moreover, watershed development programs prioritize community involvement and capacity building, fostering local ownership and empowerment.  This abstract elucidates the multifaceted benefits of watershed development in revamping rainfed farming systems, emphasizing its potential to mitigate environmental degradation, enhance agricultural resilience, and improve rural livelihoods.
Effect of Plant Growth Regulators on Growth and Flower Yield of Lisianthus (Eustoma grandiflorum) Under Prayagraj Agro Climatic Conditions
Authors: Poorani Siva , Bahadur Vijay , Fatmi Urfi
Published: July 2024

The experiment was carried out under naturally ventilated polyhouse conditions, Department of Horticulture, SHUAT S, Prayagraj, during November, 2023 to April, 2024. The experiment was laid out in Completely Randomized Design (CRD) with three replications. There were ten treatments comprising of CCC, GA3, NAA at  different concentrations viz., GA3 (100, 200, 300) ppm and CCC (250, 500, 750) ppm and NAA (30, 45, 60) ppm along with control. The results revealed that  foliar application of 300 ppm GA3 for Lisianthus, significantly enhanced the treatment T3 - GA3 at  300 ppm was found in superior among other treatments in terms of plant height (20.66cm), number of leaves (33.06), plant spread (11.3cm), stem diameter (3.23cm), leaf area (15.43cm2), bud length (2.62cm), number of buds per plant (6.43), stalk length (5.70cm), Number of flowers per plant (6.43), number of branches per plant (3.12),chlorophyll content (66.10), minimum number of days for bud initiation (122.50), Flower yield per plant (6.43), flower yield per 250m2 (40187.50), benefit cost rat io (4.08) per 250 m2 was also observed in T3 - GA3 at  300 ppm.
Assessing Prospective Bivoltine Hybrids of Silkworm (Bombyx mori L.): A Comprehensive Analysis
Authors: Attri Monika , Bali Kamlesh , Gupta R.K. , Chanotra Suraksha
Published: July 2024

It is well-known fact that hybrid selection plays a critical role in the success and sustainability of sericulture operations. Therefore, evaluating bivoltine hybrids in a region like Jammu and Kashmir (JK) serves specific purposes to the local economy and agricultural practices. In this context, the study was undertaken for one season to assess and evaluate the performance of bivoltine silkworm hybrids as potential hybrids best suitable for subtropical conditions of Jammu Division of JK. Eleven bivoltine silkworm single hybrids were selected for the study along with double hybrid check. The performance of these hybrids was evaluated based on a cumulative index i.e., E.I. value, which considered various positive traits related to egg, larval, cocoon and post-cocoon parameters. Among the twelve selected single bivoltine hybrids including check double hybrid, FC1×FC2 (59.84) which is double hybrid ranked 1st. Following the top ranked double hybrids other bivoltine single hybrids viz., PO3× ND5 (57.48), U-3×U-1 (55.77), U-4×U-6 (54.97), JD6×U-6 (51.47) and ND3 × NSP (50.84) scored cumulative E.I. value greater than 50 for positive traits and have been recognized as superior hybrids in term of egg, larval, cocoon and post cocoon parameters.
Evaluating the Role of C-reactive Protein in Reducing the Rate of Negative Appendicectomies
Authors: Odion Clement , Kpolugbo James , Dongo Andrew E. , Ogbetere Friday Emeakpor
Published: July 2024

Background: Acute appendicitis is a common surgical condition of the abdomen. However, diagnostic difficulties may arise, resulting in high rate of negative appendicectomies.
This study aimed to assess the role of C-reactive protein (CRP) in improving the                                  accuracy of diagnosis of acute appendicitis and thus reducing the rate of negative appendicectomies.
Materials and Method: The study was a cross-sectional, hospital-based study carried out on 66 patients who had appendicectomy following a clinical diagnosis of acute appendicitis. Samples for CRP were collected from all recruited patients preoperatively.  Following appendicectomy, the appendix was sent for histology. A proforma was used to collect data. All the statistical analyses were performed using IBM statistics package for social sciences (SPSS) version 21. At 95% confidence level, p-values less than 0.05 were considered significant.
Results: Thirteen (13) of the appendices removed had normal histopathologic examination, giving a negative appendicectomy rate of 19.7%. The diagnostic accuracy, sensitivity, specificity and positive predictive value for preoperative CRP were 80%, 79%, 85% and 95% respectively.
Conclusion: An elevated level of  CRP is a useful aid for the diagnosis of acute appendicitis. Deferring surgery in patients with normal CRP would likely decrease the incidence of negative appendicectomies.
TEORIA DOS SISTEMAS DO DIREITO ANIMAL GLOBAL
Authors: Fischer-Lescano Prof. Dr. Andreas , Gutmann Dr. Andreas
Published: July 2024

A Teoria dos Sistemas retira a centralidade dos seres humanos como sujeitos e se concentra no funcionamento dos sistemas de racionalidade da sociedade. É uma teoria ecológica na medida em que aborda relações sistema-ambiente. Diferentemente das abordagens unitaristas, como o Earth System Law, ela pressupõe que os sistemas sociais – a exemplo do Direito - são esferas de comunicação totalmente diferenciadas e, como tal, não são idênticos aos seus ambientes, que incluem tanto seres humanos quanto animais. Tomando a diferença entre o natural e o legal como uma relação de fronteira, uma leitura do Direito Animal Global orientada pela Teoria dos Sistemas pode tornar o direito mais sensível às preocupações dos animais.
LEIS ESTADUAIS E MUNICIPAIS ANIMALISTAS: O FORTALECIMENTO DO FEDERALISMO COOPERATIVO BRASILEIRO
Authors: Silva Priscilla , Trícia Disconzi Nina
Published: July 2024

Com o advento da Constituição Federal de 1988, o Direito Animal se consolidou no Brasil. Paulatinamente, vê-se o crescimento do Direito Animal, o qual tem ocorrido sobretudo por intermédio de suas fontes normativas. Contudo, em que pese o artigo 225, §1º, inciso VII da Constituição Federal vede práticas cruentas em face dos animais, ainda não há lei federal que os considere como sujeitos de direito. Diante disso, leis estaduais e municipais têm disciplinado sobre o Direito Animal. Nesse contexto, esta pesquisa apresenta o seguinte questionamento: as fontes normativas de Direito Animal, que são essencialmente municipais e estaduais, são suficientes à concretização do fortalecimento do federalismo cooperativo? Para tanto, a pesquisa utilizou-se do método de abordagem dedutivo e do método comparativo como procedimento. Ao final, identificou-se que as leis estaduais e municipais animalistas têm fortalecido o federalismo cooperativo, contribuindo para com a descentralização do poder legislativo; todavia, como são muito recentes, ainda não são o fundamento precípuo para demandas judiciais que tratem do direito animal.
Editorial
Authors: Pereira Lima Marcelo , Sobral Thasio
Published: July 2024

Editorial da Revista Veredas da História, v. 14, n. 1, 2021
A televisão e o soberano desconhecido em Moçambique: os efeitos de vigiar e punir os analistas
Authors: Júnior António Bai Sitoe
Published: July 2024

Este documento de pesquisa procura analisar de que modo a liberdade de expressão, se torna um ponto de entrada para compreender a violência e atos de intimidação contra analistas políticos e sociais nas televisões em Moçambique. O argumento central da pesquisa sugere que existe um soberano desconhecido no país, que surgiu através das dinâmicas de transformação e transição político-social que vigia e pune os analistas e consequentemente a toda sociedade. Com base no método de análise de conteúdo, entrevista semiestruturada e pesquisa documental, o estudo concluiu que os sequestros e agressões do soberano desconhecido contra os analistas, contribuem para mudança de direção ou resistir as novas formas de mudança e desenvolvimento que surgem com os debates analíticos nas televisões.
Controle dos corpos, controle das mentes: a necropolítica aplicada em Angola durante o governo salazarista (1926-1968)
Authors: Lima Priscila Henriques
Published: July 2024

Este artigo tem como proposta analisar a excepcionalidade de estado em Angola durante a colonização portuguesa, especificamente no percurso do governo de Antonio de Oliveira Salazar, também conhecido como Estado Novo, entre os anos de 1926 e 1968. Para isso analisaremos um conjunto de leis que demonstravam o controle dos corpos como o Ato Colonial de 1930 (Decreto nº 18.570, de 8 de julho), a Lei Orgânica de Ultramar (Lei nº 2.066, de 27 de Julho de 1953) especificamente a seção “Das populações indígenas” também conhecida como Estatuto dos Indígenas Portugueses das Províncias da Guiné, Angola e Moçambique, a Reforma Prisional do Ultramar - Decreto-Lei nº 39.997 e o Decreto-lei n.º 35.046 - Criação da PIDE (Polícia Internacional de Defesa do Estado). Para isso consideraremos que a exceção se aplica pela metrópole visando garantir a segurança do patrimônio ultramarino que, neste caso, se baseia na produção de riqueza a partir da terra dominada, mas principalmente, da mão-de-obra indígena utilizada e assegurada por contratos de trabalho implementados pelo Estatuto do Indígena. Assim, num movimento onde os corpos indígenas são colocados à disposição objetificada e lucrativa da metrópole, analisaremos as nuances da excepcionalidade considerando o conceito de necropolítica elaborado por Achille Mbembe.
Educação e luta: sobre a participação das mulheres no PAIGC, o Jornal Blufo e Amilcar Cabral
Authors: Campos Priscilla Marques
Published: July 2024

A Guiné-Bissau e Cabo Verde estiveram em luta pela libertação nacional entre 1963-1973, o PAIGC foi o partido que unificou a maior parte dos movimentos para a ação. Nesse artigo irei analisar como a presença de Amilcar Cabral no jornal estudantil, afetou o currículo da escola e uma reflexão participação das mulheres no PAIGC. O Blufo foi uma ferramenta didática, elaborada pelo PAIGC, no sentido de colaborar para formação estudantil, cultural e política das pioneiras e pioneiros, na construção de laços internacionalistas e pan-africanistas.
José Barbosa Rodrigues e a construção da identidade na infância
Authors: Alves Guimarães de Souza Santos Henry
Published: July 2024

Este trabalho tem o objetivo de realizar uma análise historiográfica das obras Campo Grande meu amor: resumo histórico e geográfico do município e Mato Grosso do Sul para a 3ª série do 1º grau, de José Barbosa Rodrigues. Além disso, contextualiza-las em seu período de publicação. A criação de um novo Estado e a designação de uma nova capital trouxe vários desafios para as instituições, as elites regionais e aos diferentes grupos sociais. Foi preciso criar a região, para além dos recortes geográficos, repensando a política, a cultura, e, sobretudo, criar uma identidade regional e sentimentos de pertença coletiva que legitimassem Campo Grande como capital. Alguns intelectuais do período, instituições e grupos foram mobilizados pelo governo estadual a fim de forjarem as identidades sul mato-grossense e campo-grandense, entre eles, estava o autor das obras analisada. Os livros foram publicados em 1978, no calor da divisão de Mato Grosso e a consequente criação de Mato Grosso do Sul, e era destinado as crianças em idade escolar. A pesquisa surgiu a partir do Programa de Iniciação Científica (PIBIC/UFMS 2018-2020) quando foram analisadas outras obras do autor. Foi possível notar que o projeto encampado na década de 1970 obteve bons frutos e ainda está bastante presente na historiografia, discursos oficiais, livros didáticos e produções acadêmicas.
Reflexões sobre o ofício do historiador e seus dilemas contemporâneos
Authors: De Sousa Kacia Mikaela
Published: July 2024

Este trabalho tem como objetivo debater algumas das características do ofício do historiador e os dilemas contemporâneos que permeiam a prática historiográfica. A partir dos debates teóricos que giram em torno do ofício do historiador, dialogaremos acerca do seu papel social na contemporaneidade, evidenciando as possibilidades e os seus desafios no mundo digital. Como referencial teórico, utilizaremos autores que tratem do papel do historiador, como Olivier Dumoulin (2017) e Jurandir Malerba (2017). Para refletirmos sobre a escrita da história, utilizaremos Michel de Certeau (1982), Roger Chartier (2010), entre outros.
Representações da Idade Média no livro didático: estratégias de ensino-aprendizagem para uma descolonização do Medievo
Authors: Rios Lima Silva Márcio
Published: July 2024

Este artigo busca abordar criticamente algumas formas como a Idade Média é representada no livro didático História e Reflexão, de Gilberto Cotrim (1996), voltado para os estudantes da 6ª série, no intuito de analisar de que forma este tipo de suporte cultural pode auxiliar no ensino escolar de História. Para cumprir com tal mister, esta pesquisa valeu-se de uma abordagem qualitativa associada ao método histórico. Os achados indicam que embora a referida obra, por vezes, apresente uma Idade Média dissonante da historiografia especializada, ainda assim seria capaz de viabilizar ao professor eficientes estratégias didático-pedagógicas para a descolonização do ensino escolar da Idade Média.
A fotografia como ferramenta para o ensino de História
Authors: De Sant Ana Obede Domingos , Roberto de Azevedo Maia Paulo ,
Published: July 2024

O presente trabalho pretende discutir o uso de imagens, mais especificamente fotografias, como ferramenta no ensino de história, abordando, através de pesquisa bibliográfica as possibilidades que este tipo de linguagem visual oferece bem como suas limitações, levando ainda em consideração o grande fluxo diário de imagens que nos chegam, com frequência cada vez maior, através de diferentes meios, sejam redes sociais, jornais impressos ou digitais, documentários ou revistas. Simultaneamente a isto, existe certa timidez quanto ao uso desta linguagem que muitas vezes acaba sendo utilizada apenas como mera ilustração em livros didáticos.
A Ditadura civil-militar paraense em sala de aula: memória, história digital e historiografia na aula de estudos amazônicos
Authors: Hugo Rocha Alves Davison
Published: July 2024

Este artigo tem por objetivo apresentar as potencialidades educativas para debater a ditadura militar no Pará, a partir dos novos enfoques metodológicos e historiográficos após a rememoração dos 50 anos do golpe-civil militar. Enquadra-se dentro de uma História do Tempo Presente e na perspectiva de História Pública através do uso de memórias, de documentos oficiais e de produção de conhecimento histórico, o professor pode abordar a temática da ditadura militar a partir de suas fases tendo como fio condutor, cinco programas construídos pelo projeto de pesquisa UFPA e os Anos de Chumbo, que estão disponibilizados para consulta e uso pedagógico dentro das aulas de História e de Estudos Amazônicos.
Ensino de História por meio das sonoridades em uma escola atingida pela Bar ragem de Fundão (Mariana-MG, 2022)
Authors: Buarque Virgínia , Aparecida Viana Cibele , Ferreira Diniz Silvany
Published: July 2024

O artigo discorre sobre os procedimentos e interpreta os resultados parciais do projeto pedagógico “Sonoridades Históricas de Bento Rodrigues”, desenvolvido a partir de agosto de 2022 na Escola Municipal Bento Rodrigues, soterrada em 2015 devido à queda da Barragem de Fundão. Realocada na sede urbana de Mariana, tem acolhido ações voltadas à superação do trauma vivido pelos(as) moradores(as) daquela comunidade, bem como ao reconhecimento de seus direitos, entre as quais o projeto aqui abordado, que porta como objetivos: 1) formular com os(as) estudantes (considerando, assim, suas memórias e cultura de história) uma ressignificação do processo histórico de ocupação da região desde o século XVII à atualidade, sob o viés das sonoridades; 2) promover uma crítica propositiva, em âmbito teórico-conceitual e metodológico, ao emprego das sonoridades no ensino de História.
Metodologia do desenvolvimento de projetos em História
Authors: Reis dos Santos Amanda
Published: July 2024

Resenha de livro.
A presença de Maria Felipa num processo judicial em Itaparica, Bahia, 1834
Authors: Moura Milton , Brito Felipe Peixoto
Published: July 2024

Trata-se da análise inicial dos autos do Processo Crime que investigou e julgou supostos atos de agressão física ocorridos na Vila de Itaparica em 1834. O documento contém quinze folhas, está incompleto e encontra-se depositado no Arquivo Público do Estado da Bahia, Seção Judiciária, 33/1381/13. Busca-se identificar, através do método prosopográfico, se Maria Felippa, acionante neste processo, em que é descrita apenas como pobre e analfabeta, denunciando o crime cometido contra ela e sua filha, obteve não só a prisão do seu agressor, como uma vitória parcial em um Tribunal de Jurados. Assim, o artigo coloca elementos para refletir sobre a historicidade e singularidade da personagem, que tem sido evidenciada nas comemorações e discussões acerca da participação da Bahia – e, no caso, da Ilha de Itaparica – no processo das lutas pela independência.
Como se fabrica um homem do mar? Considerações sobre as masculinidades no meio homossocial da pirataria moderna (séculos XVII e XVIII)
Authors: Queiroz Camila
Published: July 2024

O objetivo deste trabalho é apresentar uma proposta de análise de grupos piratas que atuaram no Atlântico entre a segunda metade do século XVII e início do século XVIII a partir da ótica de gênero. Para isso, utilizei como fonte o primeiro volume da edição inglesa da obra A General History of the Pyrates (1724).  Assim, trago considerações gerais sobre a pirataria moderna, ancoradas em Rediker e Linebaugh (2008) e Benton (2010), apresento pesquisas em torno de questões de gênero e sexualidade na pirataria, discutindo os trabalhos de Burg (1995) e Turley (1999) e, por fim, apresento minha análise com base nas propostas de Connell (1995, 2000) e Scott (1995).
Editorial
Authors: Lima Marcelo
Published: July 2024

O presente dossiê intitulado Gênero, História da Mulheres e Feminismos é uma nova edição da Revista Veredas da História, organizado por Daniele Gallindo e Marcelo Lima. Ele reúne seis estudos de pesquisadoras(es) dedicadas(os) aos campos da História Social das Mulheres, dos Estudos de Gênero e dos Estudos Feministas, entre outras áreas interdisciplinares.
Gênero, História das Mulheres e Feminismos
Authors: Lima Marcelo , Gallindo Daniele
Published: July 2024

Apresentação do Dossiê "Gênero, História das Mulheres e Feminismos", organizado por Daniele Gallindo (UFPel) e Marcelo Lima (UFBA)
Revista Veredas da História (v. 15, n.2, 2022)
Authors: Lima Marcelo , Gallindo Daniele
Published: July 2024

Versão Completa do dossiê  Gênero, História das Mulheres e Feminismos, Revista Veredas da História, v.15, n.1 (2022.1), organizada por Daniele Gallindo (UFPel) e Marcelo Lima (UFBA)
Profiling Protein Methylation with Cofactor Analog Containing Terminal Alkyne Functionality
Authors: Blum Gil , Bothwell Ian R. , Islam Kabirul , Luo Minkui
Published: March 2013

Enzymatic transmethylation from the cofactor S‐adenosyl‐L‐methionine (SAM) to biological molecules has recently garnered increased attention because of the diversity of possible substrates and implications in normal biology and diseases. To reveal the substrates of protein methyltransferases (PMTs), the present article focuses on an alkyne‐containing SAM mimic, Se‐adenosyl‐L‐selenomethionine (ProSeAM), and a cleavable azido‐azo‐biotin probe to profile the targets of endogenous PMTs in cellular contexts. This article describes the stepwise preparation of cell lysates containing active, endogenous PMTs and subsequent target labeling with ProSeAM. The article continues with the enrichment of the ProSeAM‐labeled proteins with the azido‐azo biotin probe as a pulldown reagent and the subsequent reductive elution with sodium dithionate for proteomic analysis. The protocols provided here were formulated for ProSeAM as a profiling reagent but can be applied to other terminal‐alkyne‐containing SAM analog cofactors. Curr. Protoc. Chem. Biol. 5:67‐88 © 2013 by John Wiley & Sons, Inc.
Dynamic expression of tyrosine hydroxylase mRNA and protein in neurons of the striatum and amygdala of mice, and experimental evidence of their multiple embryonic origin
Authors: Bupesh Munisamy , Vicario Alba , Abellán Antonio , Desfilis Ester , Medina Loreta
Published: March 2013

Emotional and motivational dysfunctions observed in Parkinson’s disease, schizophrenia, and drug addiction are associated to an alteration of the mesocortical and mesolimbic dopaminergic pathways, which include axons projecting to the prefrontal cortex, the ventral striatum, and the amygdala. Subpopulations of catecholaminergic neurons have been described in the cortex and striatum of several mammals, but the presence of such cells in the adult amygdala is unclear in murine rodents, and in other rodents appears to show variations depending on the species. Moreover, the embryonic origin of telencephalic tyrosine hydroxylase (TH) cells is unknown, which is essential for trying to understand aspects of their evolution, distribution and function. Herein we investigated the expression of TH mRNA and protein in cells of the striatum and amygdala of developing and adult mice, and analyzed the embryonic origin of such cells using in vitro migration assays. Our results showed the presence of TH mRNA and protein expressing cells in the striatum (including nucleus accumbens), central and medial extended amygdala during development, which are persistent in adulthood although they are less numerous, generally show weak mRNA expression, and some appear to lack the protein. Fate mapping analysis showed that these cells include at least two subpopulations with different embryonic origin in either the commissural preoptic area of the subpallium or the supraopto-paraventricular domain of the alar hypothalamus. These data are important for future studies trying to understand the role of catecholamines in modulation of emotion, motivation, and reward.