bluuebunny/crossref_metadata_2025 huggingface dataset:
Ensemble Deep Learning Network Model for Dropout Prediction in MOOCs
Authors: Kumar Gaurav , Singh Amar , Sharma Ashok
Published: February 2023

In the online education field, Massive open online courses (MOOCs) have become popular in recent years. Educational institutions and Universities provide a variety of specialized online courses that helps the students to adapt with various needs and learning preferences. Because of this, institutional repositories creates and preserve a lot of data about students' demographics, behavioral trends, and academic achievement every day. Moreover, a significant problem impeding their future advancement is the high dropout rate. For solving this problem, the dropout rate is predicted by proposing an Ensemble Deep Learning Network (EDLN) model depending on the behavior data characteristics of learners. The local features are extracted by using ResNet-50 and then a kernel strategy is used for building feature relations. After feature extraction, the high-dimensional vector features are sent to a Faster RCNN for obtaining the vector representation that incorporates time series data. Then an attention weight is obtained for each dimension by applying a static attention mechanism to the vector. Extensive experiments on a public data set have shown that the proposed model can achieve comparable results with other dropout prediction methods in terms of precision, recall, F1 score, and accuracy.
Exploring the role of green brand positioning in determining green product purchase intention
Authors: Krissanya Nofriska , Sholikhah Sholikhah , Berutu Meta Bara , Sari Dewi Agustin Pratama
Published: February 2023

In this study, we investigate the relationship between green brand positioning (GBK), attitude toward green brand (AGB) and green brand knowledge (GBK) on green product, specifically in beauty and body care products. It also sought to examine consumer’s purchase intention (PI) of this product using those variables. The methodology which is used to analyse the data obtained is using an exploratory quantitative approach. The data evaluated by Partial Least Square – Structural Equation Model (PLS-SEM). This study used purposive sampling techniques to determine the sample of employees who work in Jakarta, Bogor, Depok, Tangerang, and Bekasi (Jabodetabek), Indonesia. The outcomes indicate that all these factors contribute to purchase intention of this green beauty and body care product. This study is also found that GBP has a positive direct contribution to AGB, GBK, and PI. Originality and practical implications from this study are that, the green product companies must pay attention to the brand positioning because it would alter consumer’s attitude and intention towards of green products. Thus, companies should focus more on developing promotional messages that are more directed towards sustainable values or optimizing communities that support sustainability lifestyles. More deeply, eco-friendly beauty and body care products are very widely used today, so the results of this research are expected to contribute in terms of how can customer’s intensions are increased in buying these products.
Integration of Clustering System and Joint Venture Business Model for CCUS Deployment:
Authors: Prajna Indrasuta Martinus Bhima , Hutagalung Adryan Samuel , Putra Saeful Ghofar Zamianie , Saga Radista , Rizky Aurellia Anindita
Published: February 2023

Carbon Capture, Utilization, and Storage (CCUS) have been a 'buzzword' for the past two years, especially in Indonesia, a developing country committed to achieving net-zero emissions. However, 43% of global CCUS projects were still terminated or put on hold, mainly driven by economic inability and public acceptance. Therefore, a suitable business model and clustering system must be proposed to make carbon sequestration projects economically attractive in Indonesia. Under the Analytical Hierarchy Process (AHP) assessment collaborating with the previous study conducted by Center of Excellence ITB and Lemigas, clustering systems can be deployed in three regions: South Sumatra, West Java, and East Kalimantan. The selected CO2 sources consist of various industrial sectors surrounding the fields, aiming to facilitate the source's matching process to the possible sink. Thus, it is obtained that the Talang Jimar field (South Sumatra) becomes the highest priority and the most probable sink point with 0.584 GtCO2 storage and an annual sink capacity of 0.0292 GtCO2 for 20 years storage period. Integrating CCUS deployment in Talang Jimar with a clustering system and advanced capturing technology seriously adds commercial value to the project. A carbonate fuel cell is the proposed capturing technology for coal power plants, with expected CO2 capture efficiency by 90% and reduced electricity cost by 33%. These developing technologies and clustering systems are forcing companies to find more efficient business models to compete in the carbon market. In this study, a joint venture scheme is applied to specify the CO2 value chain in this project and to cover the capturing and transportation cost through the joint-stock cooperative system, under sharing percentage assumptions of 40% for the capturing company, 30% for storage, and 30% for transport.
Analysis of Civil Society Organisations Thematical Representation at the ASEAN Forum on Migrant Labour: A Disability Lens
Authors: Thatcher Benjamin
Published: February 2023

The development and migration nexus has expanded and built from the foundations of a human rights framework. This fusion has significant implications within ASEAN, which is positioned to increase economic integration, triggering a transformation into a labour migration hub. Meaningful participation of all stakeholders becomes a necessity to fulfil the notion of inclusive development under a human rights paradigm. However, persons with disabilities and their representation are often only mentioned as an afterthought. This secondary research accompanied by a qualitative interview investigates how persons with disabilities are represented at Civil Society level and how recommendations in the AMFL interpret disability. Unfortunately, the findings suggest persons with disabilities did not have meaningful representation and when disability was mentioned it followed a medical or charity model narrative. This narrative normally took the form of an occupational safety or health services issue offering protection from disease or injury to prevent ‘suffering’ as they should be covered by disability and medical insurance.
Displacement and the Politics of Identity: Reterritorialization of Ahıska Turk identity in the United States
Authors: Dogan Hulya
Published: February 2023

Today, most anthropologists seem to agree that world views based on the fixed category identity-place, such as the ideology of the nation-state, wrongly assume that identities are inescapable destinies, naturally predetermined by kinship ties, ethnicity, locality, and shared culture. For refugees, the complexity of their experiences in their countries of origin, and in response to their diaspora itself, add further complexities to the process of ethnic identity formation. Ahıska Turks, a stateless community, who has experienced multiple displacements, violent persecution, and ongoing exile since 1944, claim to preserve their ethnic identity during exile years in different geographic locations through a strong link of place with memory, loss, and nostalgia. This article aims to investigate whether the Ahıska Turk identity is de-territorialized and reterritorialized through adapting the routines of the host culture in everyday life in the midst of all the efforts of achieving an economically and socially self-sufficient family and community lives in the United States.
Modelo de la relación entre sentido de lugar y patrimonio urbano: propuesta teórico-conceptual
Authors: De la Torre Dávalos Alexis Antonio
Published: February 2023

La planeación urbana, sobre todo en América Latina, ha evidenciado apartarse de las políticas de planeación integral del territorio para optar por proyectos de intervención estratégica. Por lo tanto, antes de reconfigurar los lugares es necesario reconocer el complejo papel que los mismos desempeñan para la ciudad en su conjunto. Con tal fin, el presente escrito propone el modelo de la relación entre el sentido de lugar y el patrimonio urbano, en donde se determinan las siguientes cinco categorías esenciales: 1) dependencia al lugar, 2) apego al lugar, 3) identidad del lugar, 4) política del lugar, y 5) entorno construido junto a su oportunidad ambiental. De tal manera, se pretende aportar un enfoque integral que informe de la vinculación que las personas establecen con su entorno, cuyo refuerzo en última instancia convierte a un lugar ordinario en único o patrimonial.
Mas allá de los datos exitosos. La materialización de la política habitacional en Ecuador del 2007 al 2017
Authors: Hinojosa Barahona Myriam Johanna
Published: February 2023

El presente artículo recaba información sobre tres momentos históricos en las políticas habitacionales de Ecuador. El primero corresponde a la intervención estatal directa, el segundo al modelo subsidiario de vivienda, cunado el BID promueve programas habitacionales en países de la región, y el tercero cuando el gobierno de turno de corte progresista incrementa la inversión en vivienda social y financia proyectos habitacionales directamente. Es en este último momento la reflexión se enfoca en la materialización de las políticas habitacionales que promovían en el Buen Vivir, por lo que la pregunta central intenta recabar información sobre la garantía del derecho a la vivienda y a la ciudad en el país.
El capital inmobiliario, actor preponderante de la producción del espacio en las ciudades contemporáneas. Elementos teóricos para un análisis marxista: la renta urbana y el ambiente construido
Authors: Ortega Herrera José Manuel
Published: February 2023

Los incontables problemas urbanos de la actualidad encuentran una explicación en la racionalidad del funcionamiento capitalista, en específico en la personificación del capital inmobiliario, pues su reproducción en los últimos años ha sido sumamente significativa. Esto nos obliga a situar en el centro del análisis urbano, algunas categorías económicas específicas ligadas a la Economía Política marxista; nos refererimos puntualmente a los conceptos de Renta Urbana (y su determinante princicipal, el Precio del suelo) y al ambiente construido, el cual incide directamente en aquélla para cerrar un círculo virtuoso de valorización y obtención de sobre-ganancias a partir de altos precios de las mercancías bienes inmuebles que inundan gran parte de la oferta edilicia de la ciudades contemporáneas. Un entendimiento sistemático y teóricamente articulado a actividades del sector inmobiliario (la vivienda, las oficinas y el retail) y de su funcionamiento dentro del sistema capitalista, nos puede ayudar a comprender los actuales procesos urbanos.
Moverse en ciudades que arrinconan: las personas con discapacidad frente al urbanismo capacitista de la Ciudad de México
Authors: Paniagua Arguedas Laura
Published: February 2023

Este artículo presenta las experiencias de las personas con discapacidad al moverse en la Ciudad de México frente al urbanismo capacitista, un sistema de dominación en el que las formas, usos y gestión de la ciudad dan privilegios y atención a las necesidades de las personas consideradas “capaces”, con “cuerpos completos”, “inteligentes” o “sanas”. Se presenta un estudio de casos con información que se recolectó por medio de entrevistas móviles y observación participante de las movilidades. El análisis se realizó utilizando la Teoría Crip y referentes de los estudios críticos en discapacidad. Entre los hallazgos se encuentra que el urbanismo capacitista afecta a diversidad de cuerpos, incluidos los de las personas con discapacidad, pero, además, a muchas otras poblaciones. Esto evidencia que las ciudades benefician la habitabilidad de ciertos grupos en función de su clase y género.
Kärntner Raumordnungsrecht
Authors: Steinwender Robert Alexander
Published: February 2023

Einblicke, Anmerkungen und Stellungnahmen zum Kärntner Raumordnungsgesetz 2021 Im Juli 2021 wurde das Kärntner Raumordnungsgesetz 2021 erlassen, das seit 1. Jänner 2022 die gesetzliche Grundlage für die überörtliche und örtliche Raumordnung in Kärnten bildet. Nun liegt es an den handelnden Personen auf allen Entscheidungsebenen, den Zielen und Grundsätzen der Raumordnung die notwendige und gesetzlich vorgegebene Bedeutung zu geben. Dieses Werk bietet erste Einblicke und Hilfestellungen in das Kärntner Raumordnungsgesetz 2021. Es berücksichtigt neben den Zielen und Grundsätzen insbesondere die verfassungsrechtlichen Grundlagen, deren es für eine erfolgreiche Neugestaltung des raumordnungsrechtlichen Umfelds bedarf. Die Ausgabe umfasst die vollständige Sammlung der Materialien zum Kärntner Raumordnungsgesetz 2021, Anmerkungen zu den einzelnen Bestimmungen und Stellungnahmen zu einzelnen Rechtsfragen.
Tasa de mortalidad y factores de riesgo en el embarazo en adolescentes revisión sistémica
Authors: Moreno Arias Erika Samanta , Mesa Cano Isabel Cristina , Peña Cordero Susana Janeth
Published: February 2023

Introducción: El embarazo adolescente se ha vuelto un problema de salud pública, a nivel mundial se evidencia que hay altos porcentajes por lo cual es importante que sea intervenido para generar políticas públicas que ayuden a tener una disminución del embarazo adolescente. Objetivo general: Determinar la tasa de mortalidad y factores de riesgo en el embarazo en adolescentes mediante una revisión bibliográfica. Metodología: Se realizó una revisión sistemática basada en el PRISMA en diferentes bases de datos como: Web of Science, Scielo, Medline, Scopus, las palabreas claves fueron: Embarazo, Adolescencia, Mujer, Mortalidad, Riesgos y los idiomas que fueron buscados fueron español e inglés. Resultados: Se analizaron 12 artículos y se evidenció que el porcentaje más alto de prevalencia fue del 56% en Nepal, seguido de una prevalencia de 26,50% en Israel. Se determinaron prevalencias iguales del 18% en Ecuador, y prevalencias del 17% y 17.70% en Brasil. No obstante, la prevalencia más baja que se identificó fue del 5.80 % también en Ecuador para el año 2015. Las principales causas de muerte en las adolescentes embarazadas fueron los trastornos hipertensivos (28%), infección puerperal (16%), hemorragia (12%), tromboembolismo (12%) y aborto (10%). Conclusión: Incrementar programas de intervención que ayuden los adolescentes a tener claro cuáles son los métodos anticonceptivos y planificación familiar para disminuir el embarazo en adolescentes. Área de estudio: Salud
Factores de riesgo cardiovasculares relacionados con la diabetes mellitus tipo 2: Revisión sistemática
Authors: Ortiz Atiencia Gissela Vanesa , Salas Contreras Francy Hollminn
Published: February 2023

Introducción. La diabetes mellitus tipo 2 (DM2) en los últimos años ha sido considerada como una patología de amenaza para la salud mundial debido a sus complicaciones cardiovasculares, las cuales provocaron el incremento de los índices de prevalencia y mortalidad.  Objetivo. Examinar en la literatura científica sobre los factores de riesgo cardiovasculares relacionados con la diabetes. Metodología. Se realizo una revisión sistemática de publicaciones en los siguientes exploradores: Pubmed, Scopus, Web of Science, desde el año 2017, se escogieron aquellos que tuvieron alguna relación con la temática a tratar, de forma complementaria esta búsqueda se realizó utilizando las palabras claves: riesgo cardiovascular, diabetes mellitus, prevalencia, hipertensión, obesidad. Resultados. Se encontró un total de 24 artículos relacionados con el tema que reflejaron que la hipertensión arterial, hipercolesterolemia, hiperglicemias, la obesidad y el tabaquismo obesidad fueron factores de riesgo cardiovasculares relacionados con la diabetes. Conclusión. Al ser la diabetes mellitus tipo 2 de importancia mundial debido a sus índices de morbi-mortalalidad fue importante estudiarla y definir los diferentes factores de riesgo cardiovasculares relacionados con esta patología. Área de estudio: Enfermería
Manejo de hematoma subdural crónico: caso clínico
Authors: Uyaguari Yunga María Isabel , Torres Criollo Larry Miguel
Published: February 2023

Introducción: El hematoma subdural crónico es una enfermedad caracterizada por una colección de sangre en el espacio subdural (duramadre y aracnoides), es uno de los tipos de hemorragia subaracnoidea con más frecuencia y si se les brinda el tratamiento correcto a los pacientes con esta patología tienen un diagnóstico favorable. Objetivo: determinar el manejo de hematoma subdural crónico en un paciente de 62 años del Hospital San José en la Ciudad de Azogues.  Descripción caso clínico: Paciente de 62 años, sexo masculino, casado, procedente de Tulcán, residente en cuenca- Ecuador, con instrucción primaria, ocupación albañil, raza mestiza, religión testigo de jehová, tipo de sangre ORH +. Con diagnóstico de hematoma subdural crónico, con antecedentes patológicos ninguno. Evolución: Paciente después  del procedimiento quirúrgico pasa a sala  de recuperación con medidas posquirúrgicas  y luego pasa sala respectiva  con medidas anti edema cerebral, solución salina al 0.9%, anticonvulsivante, antibiótico, analgésicos, además corticoides, tras un día de recuperación paciente es dado de alta en buenas condiciones, vigil y orientado en tiempo ,espacio y persona  con escala de Glasgow 15/15, pupilas fotorreactivos , isocóricas, y se retira dren bajo normas de asepsia y antisepsia y se sutura, y se envía al paciente a domicilio  con tratamiento farmacológico ambulatorio. Conclusión: Tal fue el caso clínico expuesto, asegurando de esta manera el bienestar físico, mental y social del individuo.
Propiedades psicométricas del mini examen del estado mental: revisión sistemática
Authors: Sagbay Coronel Maricela Estefanía , Ramírez Coronel Andrés Alexis
Published: February 2023

Introducción.: Como no existe validación de MMSE para Ecuador, la elaboración de la investigación actual cobra relevancia porque es necesario adaptarse, pero para ello es necesario conocer sus aportes internacionales. Objetivo: El objetivo fue revisar la evidencia científica sobre las propiedades psicométricas del MMSE. Metodología: Se generó una revisión sistemática en la literatura científica a partir del procedimiento PRISMA, trabajando con 10 artículos publicados en diversas bases de datos como Scielo, PubMed, WOS, Scopus. Resultados: Los puntajes obtenidos con el MMSE y el MoCA están relacionados entre sí; sin embargo, los puntajes en el MoCA son más bajos y presentan una mayor dispersión en grupos de diferente edad y escolaridad, por lo que se podría utilizar un punto de corte diferente para determinar el DCL en la población de la comunidad. Conclusión: La evidencia de aquellos que usaron exclusivamente MMSE, consideran beneficioso para lograr los objetivos de medición cognitiva. En cuanto a los índices de ajuste del Mini Examen del Estado Mental, existe una variación en cuanto a los criterios de la población donde se utiliza, con una validación considerable para llevarse a cabo en diversos contextos, lo que podría contribuir a aumentar la efectividad del MMSE. Área de la ciencia: Ciencias de la Salud.
Digital technologies as a reason and tool for dynamic transformation of territory marketing
Authors: Aleinikova O. V , Datsii O. I , Kalina I. I , Zavgorodnia A. A , Yeremenko Yu. O , Nitsenko V. S
Published: February 2023

Purpose. To develop a mathematical approach to quantitative assessment of the effectiveness of digital marketing of territories. To determine the tasks of digital marketing of territories and directions for increasing its effectiveness. Methodology. The research uses general and special methods of cognition: content analysis to substantiate the use of quantitative indicators for evaluating marketing effectiveness; induction and deduction for the development of a mathematical approach to evaluating the effectiveness of digital marketing of territories; analysis and synthesis to coordinate projects under conditions of a dynamic transformation of marketing processes. Findings. The mathematical formalization of quantitative evaluation effectiveness of marketing territories is developed, provided that the possibility of implementing project approach and conditions for coordination of projects is ensured. The tasks to be solved by the digital marketing of territories and directions for increasing its effectiveness are defined, and its advantages are detailed. The scheme is proposed for the implementation of territory marketing, taking into account the direct impact of information tools on the result and the reverse impact of an inappropriate result on the choice of information tools, which dictates the need to ensure the adaptability of marketing to dynamic changes in external and internal influences. Originality. The synergistic mutual influence of territory marketing and digital technologies, the synergistic mutual influence of business activities in the territorial location and the marketing of territories is established. It is established that the factor that determines the dynamic change in marketing plans is also a significant level of uncertainty due to the dynamic change in the level of threats and the dynamic nature of the introduction of the latest technologies. Practical value. The mathematical approach of quantitative assessment effectiveness of digital marketing territories and the determination of its tasks and directions for increasing efficiency determine the practical value of the study.
The competitive strategy profile of Ukrainian inland water transport: economic justification
Authors: Burkynskyi B. V , Ilchenko S. V , Gryshchenko V. F , Gryshchenko I. V
Published: February 2023

Purpose. The work aims to build a profile of the competitive strategy of inland water transport of Ukraine and its economic justification. Methodology. The theoretical and methodological basis of the study was the fundamental scientific principles of general economic theory and transport economics, works by domestic and foreign scientists in the field of competitive strategies, economic justification of competitive strategy profiles, and sustainable economic development. We used methods such as “SNW”, “SPACE”, and “ADL” to solve the tasks of our research. The information base of the study consists of: collected, processed, and summarized primary materials of economic research, official statistics, monographs, and scientific and analytical articles of domestic and foreign authors. Findings. The work determines the economic essence of the competitive strategy profile. The profile of the Ukrainian inland water transport competitive strategy was constructed. The profile by the method of “SNW” was analyzed and economically justified by the “SPACE” and “ADL” methods. In the context of European integration, a system of strategic recommendations for the Ukrainian inland water transport competitive strategy formation was proposed. Originality. In this work, the methodological approach to building a profile of competitive strategy of inland water transport of Ukraine was further developed, which, in contrast to existing methods, includes critical elements of competitive potential, such as natural resource, production, labor, institutional, innovation and investment ones. This allows a comprehensive assessment of the results of economic threats and dangers in its use. The proposed system of recommendations for forming a competitive strategy, which will allow positioning Ukraine’s inland water transport in the European market of transport services in terms of European integration. Practical value. The presented results of the study can be used to improve the management system of Ukrainian inland waterway transport, in particular, in the part of selecting the most appropriate models of financing costs for the implementation of competitive strategies of water transport in Ukraine in the conditions of structural changes in the macro-environment in the context of overcoming the consequences of military aggression in the period of post-war recovery of Ukraine.
Forecasting the innovation of Ukraine’s economic development in a global dimension
Authors: Honcharov Yu. V , Dykha M. V , Voronina V , Milka A , Klymenchukova N
Published: February 2023

Purpose. To analyze the state and trends of innovative development of the countries of the world, to define the place of Ukraine in the international arena and forecast its innovation. Methodology. The methodological basis was formed by general scientific theoretical methods: generalization, explanation, grouping; statistical method (for a comprehensive assessment of the state and trends of innovative activity of the economies of the countries of the world and Ukraine); methods of analysis and synthesis, economic and mathematical methods of forecasting, methods of abstraction and visualization (for a visual demonstration of the actual data and the results of the study). Findings. The level of innovativeness of the world’s economies and Ukraine’s position in the ranking of the Global Innovation Index (GII) are analyzed. The positive/stimulating influence of globalization processes on the spread of innovations, as well as discriminatory methods of innovative development (“dumping” of second-order technologies in developing countries) are noted. The GII forecast is determined using a regression model of the dependence of this indicator on the specific weight of innovation-active enterprises in the total number of industrial enterprises and innovation costs. The forecasting results showed a slight downward trend in the value of the GII of Ukraine. It is argued that in order to increase the level of innovativeness of the national economy, to strengthen Ukraine’s competitive position, and taking into account the fact that the economies of other countries do not stop in their development, it is necessary to significantly intensify innovative activity in Ukraine. Originality. A scientific-methodical approach to predicting the innovativeness of economic development is proposed depending on the specific weight of innovatively active enterprises in the total number of industrial enterprises and innovation costs. There is an opportunity to carry out predictive and planning calculations of the selected forecasting object, to investigate the behavior of the macroeconomic system in the context of the innovativeness of its development, to make adjustments to the strategic management system at the state level in order to stimulate innovative processes and influence the results of the innovative development of Ukraine in the global dimension. Practical value. The proposed scientific-methodical approach makes it possible to assess the trends of the level of innovativeness of development in the future and becomes an informative basis for developing a system of measures for the activation of innovative activity.
Factor analysis of assessment of the economic potential of mining companies
Authors: Novykova I , Kulikov O , Kukhta P , Vasylkonova E , Kozlova A , Panin Ye
Published: February 2023

Purpose. Development and testing of the application of factor analysis to assess the economic potential of mining companies. Methodology. In the course of the scientific research, the authors used general scientific and special methods of cognition, such as analysis – for a critical assessment of the possibility of applying factor analysis; logical generalization – for the structural components of the assessment of the economic potential of mining companies; quantitative and qualitative comparisons – to highlight the results of factor analysis; scientific abstraction and systematization – for setting out proposals regarding the implementation of the use of factor analysis to assess the economic potential of mining companies. Findings. In the course of the research, an assessment of the economic potential of mining companies was carried out and proposals were offered regarding the possibility of using factor analysis during such an assessment. The authors have formed methodological principles for assessing the value of the economic potential of project participants and developed a typification of options for the formation of economic potential. Originality. In the course of the study, the authors selected and systematized the factors affecting the size of the formed economic potential of mining companies. The results of an expert assessment of the impact of factors on the size of the economic potential are presented. The authors also proposed a criterion for an integrated assessment of the influence of factors characterizing both quantitative and qualitative aspects of the process of forming the economic potential of project participants. Practical value. The results of the study can be used by practitioners, scientists, and civil servants (the Ministry of Education and Science of Ukraine and its structural subdivisions, local self-government bodies in the field of education and science) for the development of further prospects. Establishing ties with educational and research organizations, high-tech companies, as well as with government agencies will allow for effective exchange of experience, adaptation of educational programs, and development of skills in the application of factor analysis to assess the economic potential of mining companies.
Preclinical Evaluation of a New Anti-COVID-19 Intravenous Immunoglobulin
Authors: Nikolaeva A. M. , Ivanov A. V. , Smolyanova T. I. , Razumikhin M. V. , Belyakova O. V. , Shilova E. G. , Selezneva N. R. , Vyaznikova T. V. , Semicheva A. I. , Sakanyan E. I.
Published: February 2023

Introduction. Using of immunoglobulins containing SARS-CoV-2 neutralizing antibodies may be an effective and safe tool for COVID-19 treatment. An intravenous immunoglobulin COVID-globulin from donor blood plasma containing SARS-CoV-2 neutralizing antibodies was developed at Joint-Stock Company Nacimbio.

Aim. A pilot study of the safety of the "COVID-globulin".

Materials and methods. When studying the safety of the preparation in animals the following parameters were evaluated: general toxicity, thrombogenic potential, influence on hematological and biochemical parameters, blood clotting and hemolytic activity, determination of local irritant action, pyrogenic properties, bacterial endotoxins, allergic effect of the drug preparation and its physicochemical characteristics.

Results and discussion. Safety studies of "COVID-globulin" in animals showed no signs of intoxication, local irritant action and thrombogenic properties. Macroscopic and histological examination of the organs of rats treated with COVID-globulin showed no signs of necrosis, inflammation, atypia, or any significant pathological changes. Hematological and biochemical parameters of the blood of laboratory animals after the administration of "COVID-globulin" corresponded to the reference values. Administration of COVID-globulin to rabbits did not activate blood clot formation. The IgG subclasses distribution in the preparation corresponded to that in human plasma. The activity of the Fc-function of the immunoglobulin molecule was more than 130 % compared to the reference standard preparation, the concentration of the prekallikrein activator in the COVID-globulin ranged from 4.2 to 4.8 IU/ml, anticomplementary activity was less than 1 unit complement per 1 mg of protein.

Conclusion. The results of all studies have demonstrated a high level of safety of the developed COVID-globulin preparation, which meets the safety requirements for human immunoglobulins for intravenous administration by national regulatory documents and the European Pharmacopoeia.
Obtaining a Water-soluble Form of Hydrophobic Indolelocarbazole Derivative Using Solubilizer Complex
Authors: Kolpaksidi A. P. , Dmitrieva M. V. , Nikolaeva L. L. , Orlova O. L. , Krasniuk I. I.
Published: February 2023

Introduction. LHS-1269 is an indolocarbazole derivative with high antitumor activity. Due to the hydrophobic properties of the active substance, the use of organic co-solvents – dimethyl sulfoxide (DMSO) and ethanol – is required to obtain an injectable dosage form (DP). However, the inclusion of organic solvents in the composition of the DF carries a potential risk of side effects as a result of the use of the drug.

Aim. Selection of auxiliary substances for obtaining an aqueous solution of hydrophobic indolecarbazole derivative, which allows minimizing the concentration of organic solvents in the composition of DF.

Materials and methods. The object of the study is the active substance LHS-1269 series 010320, produced in the Chemical Synthesis Laboratory of the N. N. Blokhin National Medical Research Center of Oncology. The following auxiliary substances were used to obtain model compositions: Kollidon® 17 PF, Kollisolv® PEG-400, Kolliphor® P 188, Montanox™ 20, DMSO (p.a.), ethanol 95 % (standardized according to pharmacopoeia quality standard ФС.2.2.0019.18 of The State Pharmacopoeia of the Russian Federation). Analytical scales OHAUS Analytical Plus AP 100S and laboratory scales AND DL-120 were used for weighing LHS-1269 and auxiliary substances. The dissolution and mixing of the components was carried out on an IKA® C-MAG HS 4 magnetic stirrer.

Results and discussion. In the course of the study, 2 groups of model compositions were obtained and estimated, comprising a complex of two or more auxiliary substances as a solubilizer. The first group of formulations contained DMSO at a concentration of 5 % and ethanol at concentrations from 0 to 15 %. The compositions of the second group included DMSO from 0 to 4 %. As a result, it was found that the addition of 5 % Kolliphor® P 188 to the composition of the solution reduces the content of ethanol to 5 %. In this case, with further decrease in ethanol, turbidity of the solution and precipitation are observed. Reducing the concentration of DMSO in the DF to 2 % was achieved by using a combination of 20 % ethanol and solubilizer complex – Kollidon® 17 (20 %), Kollisolv® PEG-400 (20 %) and Kolliphor® P 188 (5 %). In this case, the total dissolution of the active substance without DMSO was observed when compensating for the organic solvent by introducing additional auxiliary substances – Montanox™ 20 (5 %) and benzene (2 %).

Conclusion. As a result of the research, the compositions of the auxiliary substances of solubilizers are selected, allowing to obtain an aqueous solution of the hydrophobic compound LHS-1269 with a minimum concentration of organic solvents.
Study of the Chemical Composition of the Fruits of Sea Buckthorh Rockthroom, Growing in the Territory of the Central Black Earth Region
Authors: Trineeva O. V.
Published: February 2023

Introduction. The chemical composition of plants is a combination of all primary and secondary metabolites and can be considered as the result of the implementation of genetic information, a «link» between the genotype and phenotype. The complex of biologically active substances (BAS) of most medicinal plants and medicinal herbal preparations derived from them is a multicomponent system that is in interaction, the composition of which is not always fully known. Sea buckthorn is one of the valuable plants with a wide distribution area. Sea buckthorn fruits contain a large number of classes of various BAS. The study of the variability of the chemical composition depending on the climatic conditions of growth, harvesting and drying in order to accumulate and generalize information for the development of unified scientifically based standards for raw material quality indicators is an important area for study.

Aim. The purpose of this work was to study the chemical composition of the fruits of sea buckthorn, which grows in the Central Chernozem region.

Materials and methods. The raw materials for the analysis were whole fresh fruits of sea buckthorn, harvested in the territory of the Central black earth region of the Russian Federation (Voronezh region). In the work, the TLC method was used to study the composition of various groups of BAS and their identification in extracts from the studied raw materials. In the process of a comprehensive study of the chemical composition of fruits, the determination of carotenoids, flavonoids, tannins, amino acids, hydroxycinnamic acids, anthocyanins, organic acids, sugars, some macroelements and vitamins was carried out.

Results and discussion. The fruits of sea buckthorn, growing in the conditions of the Central black earth region, accumulate free amino acids, tannins, organic acids and polysaccharides in significant quantities. The composition of free water-soluble simple sugars, organic acids, B vitamins, as well as the complete amino acid composition was studied in the fruits of sea buckthorn using capillary electrophoresis. A significant content of riboflavin and choline, as well as malic and succinic acids has been established. The results of HPLC analysis showed that flavonoids in the fruits of sea buckthorn growing in the conditions of the Central black earth region are represented by flavonol glycosides – derivatives of quercetin, kaempferol and isorhamnetin. Minor flavolglycosides 3-rutinoside-7-rhamnosides of isorhamnetin, quercetin and kaempferol, 3-sophoroside-7-rhamnosides of quercetin and kaempferol, rutin, 3-glucoside and 3-rhamnoside of isorhamnetin can be used as chemomarkers.

Conclusion. The obtained data on the component composition of the phenolic fraction of the fruits of the studied samples of sea buckthorn are similar to the literature data on sea buckthorn of the same species of various varieties harvested in the conditions of the Central zone of the Russian Federation (Moscow region).
ІНФОРМАЦІЙНО-ОБЧИСЛЮВАЛЬНА КОМПЕТЕНТНІСТЬ МАЙБУТНІХ ФАХІВЦІВ З ІНФОРМАЦІЙНИХ ТЕХНОЛОГІЙ
Authors: Капітон Алла Мирославівна
Published: February 2023

Розглянуто ключові компетентності майбутніх фахівців як нову парадигму результатів вищої освіти. Вивчено зарубіжний досвід професійної підготовки ІТ-фахівців зарубіжних вузів. Доведено, що фахова компетентність фахівців не є простою сумою предметних знань у випускників університетів, а є результатом сформованої сукупності загальнокультурних, професійних і загальних компетентностей.
Досліджено зміст загальних компетентностей майбутніх фахівців у галузі знань «Інформаційні технології». Доведено недосконалість та можливість доповнення структури спеціальних компетентностей майбутніх фахівців з інформаційних технологій шляхом виокремлення її інформаційно-обчислювального компонента.
Визначено інформаційно-обчислювальну компетентність фахівця з інформаційних технологій, що може бути додана до переліку спеціальних компетентностей. Обґрунтовано, що інформаційно-обчислювальна компетентність фахівця з інформаційних технологій не лише повинна бути додана до переліку спеціальних компетентностей, а являє собою інтегративну особистісну якість, сутністю якої є готовність майбутнього спеціаліста ефективно використовувати набуті під час навчання знання та вміння для вирішення завдань з інформаційно-обчислювальної діяльності, що виникають в процесі професійної діяльності, зокрема усвідомлення ним соціальної значущості цієї діяльності, його особистої відповідальності за її результати.
Розроблено освітній програмний продукт, який впроваджено в освітній процес університету на етапі оцінювання рівня сформованості фахових компетентностей здобувачів вищої освіти в галузі знань з інформаційних технологій. При виконанні роботи визначено та вирішено задачі фахового освітнього проєкту, що передбачає оцінку формування інформаційно-обчислювальної компетентності майбутніх ІТ-фахівців. Доведено, що доповнення складових розробленого програмного продукту має вплив на підвищення рівня сформованості спеціальних компетентностей майбутніх фахівців з інформаційних технологій, зокрема шляхом виокремлення його інформаційно-обчислювального компонента. Визначена потреба в постійному вдосконаленні в зазначеному вигляді професійної діяльності. Визначено подальші напрями вдосконалення структури професійних компетентностей майбутніх фахівців з інформаційних технологій.
STUDENT ENGAGEMENT, CHALLENGES AND COPING MECHANISMS IN HIGH SCHOOL ONLINE DISTANCE LEARNING DURING COVID-19 PANDEMIC
Authors: Maypa Aurielle Lisa Z. , Marcial Dave E. , Montemayor Jade O.
Published: February 2023

Most educational institutions made sure that instruction was uninterrupted at the start of the COVID-19 pandemic. As a flexible learning method, most schools chose online distance learning (ODL). Consequently, the Internet is among the many tools that ensures continuity in teaching and learning. Many schools have adopted ODL using their learning management system (LMS). However, schools are challenged in attaining the expected engagement among students. Students must cope with the new learning environment wherein they are physically separated from teachers and peers. This research aims to assess the engagement of senior high school in the ODL environment. Specifically, it describes the respondent’s engagement profile, preferred learning resources and activities, and challenges faced in ODL. Student logs from the university LMS during the second semester of 2020 – 2021 were utilized for engagement profiling. On the other hand, an online survey was conducted among 424 students to gather their preferred learning resources, activities, and challenges experienced in ODL. Results show that assignments and files are the most common resources used during the ODL. It shows that attendance and quizzes are what students often visit. Quiz and Wiki are where students spend their time. The result indicates that Slideshows and PDF or MS word materials are the most preferred learning materials. The Lesson is the most preferred learning activity, and students perceived that this activity is the most useful in the ODL. Lack of motivation or confidence earned the highest mean of 3.49, described as “every time.” Heavy workload, procrastination, lack of interaction, and technical issues are rated “every time,” showing that respondents are heavily challenged. In terms of coping, the result indicates that daily login and breaking down responsibilities were the most common mechanism. Communicating with the teachers yielded the lowest coping mean. The study concludes that engaging students in online distance learning are very challenging, especially when learners are not ready. Preferences in terms of learning resources and activities are multi-faceted. There is a need to improve the variation of asynchronous activities like interactive multimedia, such as gamification.
ERFORMANCE ANALYSIS OF ALEXNET CONVOLUTIONAL NEURAL NETWORK (CNN) ARCHITECTURE WITH IMAGE OBJECTS OF RICE PLANT LEAVES
Authors: Cobantoro Adi Fajaryanto , Masykur Fauzan , Sussolaikah Kelik
Published: February 2023

Rice is a staple food consumed by Indonesian people, even 75% of the world's population consumes rice and it is mostly found in Asia. Rice derived from pounded rice is a staple food so it can be consumed. In the process of planting rice, pests and diseases are not spared so that it can affect crop yields. Pest and disease attacks need fast, accurate and precise handling so that crop failures. In this paper, we will discuss the classification of leaf diseases of rice plants using the Convolutional Neural Network (CNNN) algorithm, especially the Alexnet architecture. There are 4 types of disease, namely Brown spot, Leafblast, Hispa and Healthy. Models built based on the Alexnet architecture may have differences in the level of accuracy and loss compared to other architectures due to the different stages in the sequential model formation. The dataset used is public data from Kaggle consisting of 4 classes with a total of 1,600 images. In each class the dataset is divided for training, testing and validation datasets with a ratio of 70:20:10. As for tools in the process of training datasets using Google Colab from Google. After going through the stages of the research, the research results obtained are accuracy worth 99,22%, mean average precision worth 0,24 and loss worth 0,05.
Influence of nearby environment on recreational bycatch of sea turtles at fishing piers in the eastern Gulf of Mexico
Authors: Reimer J , Siegfried T , Roberto E , Piacenza SE
Published: February 2023

Incidental bycatch of sea turtles from recreational fisheries is generally undocumented globally. At Gulf of Mexico fishing piers in the USA, bycatch is a source of injury and potential mortality of sea turtles. Recreational sea turtle bycatch has grown substantially over the last 6 yr, especially at the Navarre Beach Fishing Pier (NW Florida); the reasons for the increase and the impacts this has on the recovery of northern Gulf of Mexico sea turtle populations are largely unknown. In particular, the reasons why fishing piers are attracting sea turtles are not well understood or if the environmental context of other nearby habitats contributes to the bycatch. Using GIS, we analyzed potential environmental predictors of total sea turtle bycatch, across green sea turtles Chelonia mydas, loggerhead sea turtles Caretta caretta, and Kemp’s ridley sea turtles Lepidochelys kempii. We collated bycatch and environmental data from 20 Florida Gulf of Mexico fishing piers. We statistically assessed relationships using generalized additive models and selected the best fit model using the information-theoretic approach. We found that tonnage of nearby artificial reefs (based on defined home range and core use areas) and distance to nearest seagrass bed exhibit positive relationships with green sea turtle bycatch. For combined loggerhead and Kemp’s ridley bycatch, area of preserved water, distance to nearest seagrass bed, tonnage of nearby artificial reefs, and latitude of fishing piers were all predictors in the confidence set, but the shape of the relationships is variable and nonlinear. Further examination of sea turtle bycatch, occupancy of piers, and environmental factors pertaining to sea turtles will likely improve mitigation measures for recreational bycatch.
Variation in isotopic niche partitioning between adult roseate and common terns in the Northwest Atlantic
Authors: Legett HD , Lucas JR , Craig EC , Staudinger MD
Published: February 2023

Co-occurring species with similar resource requirements often partition ecological niches at different spatial and temporal scales. In the Northwest Atlantic (NWA), federally endangered roseate terns Sterna dougallii nest almost exclusively in coastal island colonies alongside common terns S. hirundo. Roseate terns are prey specialists compared to common terns, which are opportunistic generalists; however, the 2 species forage on similar resources during the breeding season. The degree to which these species overlap in their adult foraging ecologies is not well understood. We compared the isotopic niches of nesting adult roseate and common terns by analyzing stable carbon (δ13C) and nitrogen (δ15N) isotopes in eggshell membrane tissues collected in 2018 and 2019 from 10 colonies that span their NWA breeding range. Our aim was to characterize interspecific patterns in δ13C and δ15N values, isotopic niche breadth, and isotope niche overlap. We additionally examined interannual and subregional differences between ‘cold-water’ colonies in the Gulf of Maine and ‘warm-water’ colonies in Southern New England and Long Island Sound. At the range-wide scale, there was a high degree of overlap in the overall isotopic niches of the 2 species; however, more variable patterns were observed at the colony scale, ranging from nearly complete overlap to complete separation. The isotopic niches of roseate terns were generally narrower than those of common terns, consistent with their respective specialist/generalist tendencies. While the influence of isotopic baselines limits our interpretation of interannual and subregional differences, isotopic niche breadths and overlap suggest consistency of relative foraging ecologies across these scales.