bluuebunny/crossref_metadata_2025 huggingface dataset:
The Bridge That Binds Us: Exploring How Self-Forgiveness Can Help People Live a Content Life
Authors: Win Maria Viola , Irawan Stefanny
Published: September 2022

This article aims at exploring the importance self-forgiveness to help people live a content life. Self-forgiveness is a willingness to abandon self-resentment in the face of one’s own mistake while fostering compassion, generosity, and love toward one-self. Self-forgiveness itself is still an underrated topic because there has not been a lot of research into it. This article explores the reason behind the difficulty of self-forgiveness and ways that someone can take to self-forgive. Moreover, we use Conceptual Analysis of Self-Forgiveness, a psychological approach. The finding of this article is in the form of a novella. The novella tells a story using a contemporary fantasy genre, about a girl and a boy, Luci and Von, who are struggling with their past guilt. After spending time together, Luci is able to muster up the courage to apologize which helps her forgive herself and Von also learns the truth about the accident that happened in the past then visits his dead parents’ grave which also helps him forgive himself and move on.Keywords: self-forgiveness, novella, contemporary fantasy
Derik The Dutch and The Klapertaart and Other Stories: Children’s Picture Book Exploring Racist Bullying
Authors: Setianto Angelica Livianita , Irawan Stefanny
Published: September 2022

This paper discusses the process of making children’s picture book with low fantasy as the genre which explore racist bullying among children. The creative work emphasizes on the victims more than the bullies, thus, three stories implement Transactional Theory of Stress and Coping to show how children can cope with the stress of being racially bullied. The main characters in the three stories use problem focused coping, especially planful problem solving to stop the racist bullies from bullying them. The other two stories use Developmental Intergroup Theory to show how children learn prejudices toward other races by learning from the adults around them. The main characters in the last two stories are influenced by the adults around them in developing prejudices against others of different races and bullying them.Keywords: Racist Bullying, Coping Strategy, Transactional Theory of Stress and Coping, Developmental Intergroup Theory, Children’s Picture Books, Low Fantasy.
Promoting Toko Aneka Gelas Through a Promotional Video
Authors: Joshua Ronaldo
Published: September 2022

Toko Aneka Gelas was established in 1998. It is located at Saranani No.39, Makassar. Toko Aneka Gelas is the shop that sells household in category of tableware like glass, plate, jar, etc. The average the products sold in the shop is made of glass. Toko Aneka Gelas has a problem that must be solved immediately which is Toko Aneka Gelas experienced decrease sales since five years ago. Therefore, the best solution to solve this problem is to make a promotional video. The reason why a promotional video is the best solution to overcome the problem is because it can help increase the customer and also can attract the new target customer which is Café owners. The promotional video was made following Colman (2019) in order to make good promotional video. The solution will give three benefits according to Mishra (2015). The benefits are: it is increasing brand awareness, segment identification, and the customer traffic. Keywords: promotional video, sales, promoting
Increasing the Brand Awareness of Sahabat Christian School through A Website
Authors: Hia Irene Juliana
Published: September 2022

Sahabat Christian School Batam was established in 2011. This school provides 2 programs which are Kindergarten program and Elementary programs. Sahabat Christian School Batam also has 2 competitors, which are Holy Vision School (Visi Kudus) and Eben Haezer school. They were considered as competitors because of the price, location, and service. The main problem of Sahabat Christian School is low brand awareness. In other words there are only a few people who know about the existence of this school and some people know about this school but they do not really know what services that this school offers. In order to solve this problem, Sahabat Christian School needs a tool which can highlight their Uniques Selling Point to give credible and trustworthy information about this school. This tool is a website. As the main purpose is to increase brand awareness, a website will be the best solution since a website can help to highlight the Uniqueness and provides school’s information in detail and trustworthy. There are 3 highlighted USP’s: Christian Academic, Christian values, and non-academic. By highlighting their USP could increase the school brand awareness and persuade them to use the school’s services.Keyword: Promotional Tool, Brand Awareness, Unique Selling Point, Website
Heteronormativity in BL Webtoons Love is an Illusion, Room to Room, and Path to You
Authors: Dewi Agnes Katarina Candra , Mochtar Jenny
Published: September 2022

This study exploring three BL Webtoons is for taking a closer look on how the characteristics of heterosexuality can be found in BL Webtoons. To achieve that purpose, the theories used cover the set formula of male and female illustrations and gender roles. The first analysis is about the physical appearance by going into details of the physical build, facial features, and biology of the masculine and feminine males. The second one is the actions to see the feminine and masculine characters’ different ways of acting and thinking. The result of the analysis reveals how feminine males in these three BL Webtoons are depicted the same way as females are. The fact that gender identity and gender roles that describe heterosexuality are present,  shows that these three BL Webtoons  are narrated in the framework of heterosexuality. So, heteronormativity, the view that heterosexuality is the default, succeeds in infiltrating BL Webtoons. Keywords: BL Webtoon, heteronormativity, gender roles, homosexuality
Tales of Tristoria: Exploring Finding Meaning of Life Through Acceptance of Death
Authors: Noverian Jeremi , Setiawan Dwi
Published: September 2022

Humanity has their own meanings of life. Those meanings are meant to guide them towards fulfillment. People have different triggers that propel them to find their meanings of life, for example death anxiety. This novel project follows Trista, the bearer of a Curse which has the power to kill her if she uses it. As a result, she fears death and struggles to find her meaning of life, because she feels sorrow caused by her death anxiety. To better explore the issue, I apply Paul Wong’s Meaning Management Theory about meaning of life and death anxiety in the story. I find that death anxiety makes someone like Trista experience a life-changing experience to motivate her to find meaning, and the death anxiety subsides when a person finds meaning, accepts, and no longer fears death. A person who finds meaning will live life to the fullest based on their meanings. Keywords: Meaning of life, death anxiety, death acceptance
Web Mining Using Improved Apriori Algorithm
Authors: Malik C.K. Mohammed
Published: September 2022

In this study, we will be concentrating on one of the more recent advancements in data mining, specifically mining online usage. The purpose of web use mining is to gain usable knowledge from the data that web servers keep about the actions of its visitors by mining the data that is stored on such servers. By using the association rule generation in the Web domain, the pages that are most frequently referenced together can be combined into a single server session. This is possible because of the interconnected nature of the Web. In association rule mining, a technique known as frequent set mining is one of the methods that may be used to discover regular patterns from a web log file. When it comes to mining the usage of the web, the term association rules refers to groups of web pages that are accessed together and have a support value that is higher than a given threshold. The support can be expressed as a proportion of total transactions that match a particular pattern. With the aid of the presence or absence of association rules, web designers are able to effectively reconstruct the websites they have created for their clients. In this research, we have introduced a method called Aprior for the purpose of extracting frequent patterns from online log files. The findings of the experiments that were carried out on data relating to peoples use of the website indicate that general sequential patterns or frequent item sets are more suitable for use in Web customization and recommender systems.
Content based Image Retrieval Using Clustering Method
Authors: Malik C.K. Mohammed
Published: September 2022

Content-based image retrieval (CBIR) is the deployment of computer vision methods to the information retrieval challenge, that is, the subject of seeking out digital images in vast databases. Techniques based on automated feature extraction methods for obtaining similar images from image databases are under the purview of CBIR. Traditional content based image retrieval (CBIR) systems extract a single feature at a time and use it to categorize and group images in response to a query. To bridge the gap between high-level concepts and low-level features, our innovative method integrates many feature extraction algorithms. In color-based retrieval, we use quadratic distance formulas to calculate the HSV affinity matrix for photos in the query and the database. Wavelet decomposition at six stages is used in texture-based retrieval. Finding the similarity measures between the query image and the images in the database is done with the help of the Euclidean distance classifier. The integrated method used to decrease the file sizes of the retrieved photographs keeps the user from having to pay as much attention to the process.
The Mediating Role of Pre-service Teachers' Attitudes Towards Scientific Research
Authors: BOZOĞLU Gizem Nisa , YAVUZ Emine
Published: September 2022

In this study, it was aimed to determine the indirect effects of pre-service teachers’ attitudes towards scientific research on the relationship between their information literacy self-efficacy, their critical thinking dispositions, and their gender. The population of the research, in which the correlational research model was adopted, consists of pre-service teachers who continue their education at a state university in the Central Anatolia Region in the 2021-2022 academic year; the sample consists of 464 pre-service teachers selected from the population through simple random sampling. Personal information form in which demographic variables were asked, the Attitudes towards Scientific Research Scale, the Information Literacy Self-Efficacy Scale, and the Critical Thinking Tendency Scale were used as data collection tools in the research. Hayes' Model 4 was tested to examine the effect of the mediator variable. As a result of the analysis, it was determined that pre-service teachers' attitudes towards scientific research had a positive partial mediator effect on the relationship between their critical thinking dispositions and information literacy. Similarly, pre-service teachers' attitudes towards scientific research had a positive partial mediator effect on the relationship between their gender and information literacy. Accordingly, it is recommended that faculty members in education faculties plan their lessons in a way that will allow pre-service teachers to increase their positive attitudes towards scientific research.
The Imposter Dance of Alternating QRS Complexes
Authors: Yu An-Li , Chen Ying-Hsien , Lin Po-Chih
Published: September 2022

This case report describes a patient in their late 50s with acute onset chest pain with diaphoresis.
Evaluation of Supplemental Benefits Across Medicare Advantage Plans and Beneficiary Demographic Characteristics, 2019 to 2022
Authors: Rowen Neil P. , Stewart Lucas , Saunders Robert S.
Published: September 2022

This cross-sectional study evaluates how policy changes for Medicare Advantage plans affected supplemental benefit availability across geographic social vulnerability, membership diversity, and rebates from 2019 to 2022.
Prevalence and Sources of Duplicate Information in the Electronic Medical Record
Authors: Steinkamp Jackson , Kantrowitz Jacob J. , Airan-Javia Subha
Published: September 2022

Importance

Duplicated text is a well-documented hazard in electronic medical records (EMRs), leading to wasted clinician time, medical error, and burnout. This study hypothesizes that text duplication is prevalent and increases with time and EMR size and that duplicate information is shared across authors.

Objective

To examine the prevalence and scope of duplication behavior in clinical notes from a large academic health system and the factors associated with duplication.

Design, Setting, and Participants

This retrospective, cross-sectional analysis of note length and content duplication rates used a set of 10 adjacent word tokens (ie, a 10-gram) sliding-window approach to identify spans of text duplicated exactly from earlier notes in a patient’s record for all inpatient and outpatient notes written within the University of Pennsylvania Health System from January 1, 2015, through December 31, 2020. Text duplicated from a different author vs text duplicated from the same author was quantified. Furthermore, novel text and duplicated text per author for various note types and author types, as well as per patient record by number of notes in the record, were quantified. Information scatter, another documentation hazard, was defined as the inverse of novel text per note, and the association between information duplication and information scatter was graphed. Data analysis was performed from January to March 2022.

Main Outcomes and Measures

Total, novel, and duplicate text by note type and note author were determined, as were the mean intra-author and inter-author duplication per note by type and author.

Results

There were a total of 104 456 653 notes for 1 960 689 unique patients consisting of 32 991 489 889 words; 50.1% of the total text in the record (16 523 851 210 words) was duplicated from prior text written about the same patient. The duplication fraction increased year-over-year, from 33.0% for notes written in 2015 to 54.2% for notes written in 2020. Of the text duplicated, 54.1% came from text written by the same author, whereas 45.9% was duplicated from a different author. Records with more notes had more total duplicate text, approaching 60%. Note types with high information scatter tended to have low information overload, and vice versa, suggesting a trade-off between these 2 hazards under the current documentation paradigm.

Conclusions and Relevance

Duplicate text casts doubt on the veracity of all information in the medical record, making it difficult to find and verify information in day-to-day clinical work. The findings of this cross-sectional study suggest that text duplication is a systemic hazard, requiring systemic interventions to fix, and simple solutions such as banning copy-paste may have unintended consequences, such as worsening information scatter. The note paradigm should be further examined as a major cause of duplication and scatter, and alternative paradigms should be evaluated.
Fast Room‐Temperature Synthesis of an Extremely Alkaline‐Resistant Cationic Metal–Organic Framework for Sequestering TcO4− with Exceptional Selectivity
Authors: Kang Kang , Liu Shengtang , Zhang Meiyu , Li Lei , Liu Chuanying , Lei Lecheng , Dai Xing , Xu Chao , Xiao Chengliang
Published: September 2022

Leveraging metal–organic framework (MOF) to eliminate radioactive contaminants has invariably received much attention, but low preparation efficiency and poor selectivity have still limited its actual application. Herein, it is found that a fourfold interpenetrated cationic MOF (Ag‐TPPE) can be rapidly synthesized by only mixing, stirring, or sonication at room temperature. More impressively, the preparation process can be completed in <1 min. Up to now, this is the first report that cationic MOFs can be obtained by directly mixing the corresponding raw materials at room temperature. In addition to holding the rare merits of structural stability in extremely strong bases (8 m NaOH), Ag‐TPPE can selectively remove TcO4− in the presence of large excess SO42− or NO3−. Based on its ultra‐high selectivity, Ag‐TPPE exhibits exceptional removal rate for TcO4− from simulated Hanford and Savannah River Site waste streams, which refreshes the record of selective sorption of TcO4− at low solid/liquid ratio, overcoming the drawback of overused sorbent in treatment of radioactive waste solution. Such superior sorption capabilities are thoroughly elucidated by the density functional theory calculations on a molecular level, clearly disclosing that TcO4− can enter into the framework through breathing effect and is trapped in the large cavity through dense hydrogen bonds.
Bioengineered Protein Fibers with Anti‐Freezing Mechanical Behaviors
Authors: Zhang Peng , Li Jingjing , Sun Jing , Li Yuanxin , Liu Kai , Wang Fan , Zhang Hongjie , Su Juanjuan
Published: September 2022

Most biological protein fibers exhibit extraordinary mechanical performance at room temperatures but inferior freezing resistance. Maintaining fiber's high strength and toughness under subzero conditions remains a great challenge. Herein, a class of freezing tolerant protein fibers is reported with favorable ice‐phobic capacity and cryogenic mechanical performance by genetic engineering. Inspired by nature, chimeric recombinant proteins consist of highly ordered structural protein domains and antifreeze protein (AFP) modules, showing excellent ice recrystallization inhibition activity. Such features endow the resulting protein fibers with remarkable mechanical properties and good mechanical stability in subzero environments. In stark contrast to conventional fibers, the engineered protein fibers maintain high cryogenic stiffness and toughness even at −20 and −40 °C. The synergistic contribution of structural protein and AFP plays an important role for the extraordinary anti‐freezing mechanical behaviors. Thus, this study pioneers an engineering approach for the next generation of biological fibers with tailored applications in extreme settings.
Totally Organic Hydrogel‐Based Self‐Closing Cuff Electrode for Vagus Nerve Stimulation
Authors: Terutsuki Daigo , Yoroizuka Hayato , Osawa Shin‐ichiro , Ogihara Yuka , Abe Hiroya , Nakagawa Atsuhiro , Iwasaki Masaki , Nishizawa Matsuhiko
Published: September 2022

An intrinsically soft organic electrode consisting of poly(3,4‐ethylenedioxythiophene)‐modified polyurethane (PEDOT‐PU) is embedded into a bilayer film of polyvinyl alcohol (PVA) hydrogels for developing a self‐closing cuff electrode for neuromodulation. The curled form of the PVA hydrogel is prepared by releasing internal stress in the bilayer structure. The inner diameter of the cuff electrode is set to less than 2 mm for immobilization to the vagus nerve (VN) of humans and pigs. The stability of the immobilization is examined, while the pressure applied to a nerve bundle is at a harmless level (≈200 Pa). Since the electrode is totally organic, MRI measurements can be conducted without image artifacts. The large electric capacitance of the PEDOT‐PU (≈27 mF cm−2) ensures a safe stimulation of living tissues without Faradaic reactions. The practical performance of the cuff electrode for VN stimulation is demonstrated by observation of bradycardia induction in a pig.
Dextran and Its Derivatives: Biopolymer Additives for the Modulation of Vaterite CaCO3 Crystal Morphology and Adhesion to Cells
Authors: Campbell Jack , Ferreira Ana M. , Bowker Laura , Hunt John , Volodkin Dmitry , Vikulina Anna
Published: September 2022

Nowadays, a great demand for the development of novel drug delivery systems with high potential for bench‐to‐market transition attracts scientific attention toward materials that are already approved for biomedical use. Here, controlled fabrication of hybrid organic inorganic mesoporous crystals is realized in physiologically relevant conditions by co‐synthesis of vaterite CaCO3 in the presence of dextran (DEX) or its functional derivatives. The effects of DEX molecular weight and chemical structure on morphology, porosity, and stability of the hybrids are investigated. Molecular weight of DEX does not affect the crystal growth but leads to the partial blocking of crystal pores. Co‐synthesis of DEX functionalized with either carboxymethyl (CM) or diethylaminoethyl (DEAE) groups drastically increased crystal porosity without influencing crystal size. pH‐dependent vaterite‐to‐calcite recrystallization is significantly suppressed by inclusion of carboxymethyl‐dextran (CM‐DEX), making vaterite crystals stable in acidic medium, whereas the incorporation of diethylaminoethyl‐dextran (DEAE‐DEX) has no effect. The hybrids prepared with charged DEX derivatives possess stronger adhesion to normal human dermal fibroblasts: three times higher crystal adherence compared to pristine crystals. These results provide fundamental physical–chemical insights into the crystallization of DEX/vaterite hybrids and are discussed in view of the potential of these functional delivery carriers for biomedical and other applications.
Excellent Adhesive Performance for the Thermal Insulation Attribute to Micromorphology Regulation and Controllable Injection of Oxygen‐Containing Groups by Low Temperature Plasma Treatment
Authors: Yu Haomiao , Qin Yang , Wang Deqi , Xu Dongming , Di Yang , Jia Hongbing , Li Fengsheng , Liu Jie
Published: September 2022

A low temperature plasma (LTP) surface treatment technology operated under atmospheric conditions with air as the treatment atmosphere is developed for micromorphology regulation and controllable injection of oxygen‐containing groups on the surface of ethylene propylene diene methylene (EPDM) thermal insulation to achieve excellent adhesion performance. Optical emission spectroscopy is used to analyze the active species in the LTP. The key treatment parameters are optimized by contact angle measurements, resulting in thermal insulation sample with 3.32 times higher surface energy than the original sample. The surface morphology and composition of the samples are characterized. It is demonstrated that the surface of the thermal insulation shows new structures, thus increasing the surface area of the thermal insulation. In addition, a large number of oxygen‐containing groups are introduced to the surface of the thermal insulation, especially OH, and the O/C increases by 78.57%. Finally, the peel test is performed on the insulation samples with comparison to the grinding samples, which shows that the peel strength of the treated samples increases by 126.92%, while an additional 22% is also obtained compared to the grinding samples. This excellent adhesive performance is mainly caused by the synergistic effect of chemical crosslinking, hydrogen bonding, and mechanical interlocking.
Potassium Methacrylate Additive Strategy for Improved Stability of Ultrathin Copper‐Based Perovskite Solar Cells
Authors: Lin Huang , Miao Renjie , Fu Sheng , Wang Haiqiao , Lai Huahang , Wang Weiyan , Song Weijie
Published: September 2022

Perovskite solar cell (PSC) using ultrathin metal transparent electrode is a promising power source for wearable electronics and aerospace applications. However, the environmental stability of device is challenging, due to the undesirable interdiffusion of metal and halogen ions. In this work, PSCs are constructed by using ultrathin copper (Cu) electrodes with low reactivity, combined with potassium methacrylate (KMMA) additive. On one hand, carbonyl groups in KMMA interact with the perovskite and improve quality of perovskite films. As a result, the power conversion efficiency (PCE) of ultrathin Cu‐based PSC is increased from 12.49% to 14.72%. On the other hand, benefitting from the binding of K+ with halogen ion, the interdiffusion of Cu and I ions is hindered. Thus, PSCs retain 80% and 75% of the initial PCE under heating at 85 °C for 130 h and maximum power point for 300 h, respectively. To the best of the knowledge, it is one of the best thermal and operational stability for the PSCs using metal‐based electrodes. At last, the symmetric PSCs exhibit superior folding stability which maintain 85.3% of initial PCE after folding for 500 cycles. Foldable PSCs on ultrathin Cu electrodes with excellent stability are attractive power sources in wearable applications.
Temperature‐Tunable Terahertz Perfect Absorber Based on All‐Dielectric Strontium Titanate (STO) Resonator Structure
Authors: Zhao Jingcheng , Cheng Yongzhi
Published: September 2022

A temperature‐tunable terahertz (THz) perfect absorber (PA) composed of a periodic array of deep subwavelength micro‐cross‐shaped (MCS) structures of the strontium titanate (STO) resonator is proposed and investigated theoretically, which can be applicable for the temperature sensing. Simulation results indicate that the absorbance of 99.8% at 0.221 THz can be achieved when the designed PA is under the room temperature of T = 300 K, which is in good agreement with the calculation done by the coupling mode theory (CMT). The simulated distributions of electric and magnetic fields in the unit‐cell structure of the designed PA reveal that the observed perfect absorption is mainly attributed to the Mie resonance of the all‐dielectric MCS structure STO. In addition, this designed PA is polarization‐insensitive and wide‐angle absorption for both transverse magnetic (TM) and transverse electric (TE) waves. The resonance absorption properties of the designed PA can be controlled by changing the geometrical parameters of STO resonator structure. The designed PA can be served as a temperature sensor, which has a sensitivity of about 0.37 GHz K−1 since the electrical property of the STO is dependent on the variation of surrounding temperature. Furthermore, the perfect absorption can also be achieved by the PAs using the square, circular, and ring STO structures. The proposed design concepts of the STO‐based tunable PAs can find potential THz applications in sensing, detecting, imaging, and so on.
Intraparticle Double‐Scattering‐Decoded Sonogenetics for Augmenting Immune Checkpoint Blockade and CAR‐T Therapy
Authors: Wang Duo , Zhang Mengqi , Zhang Yan , Qiu Guanhua , Chen Jie , Zhu Xiaoqi , Kong Cunqing , Lu Xiuxin , Liang Xiayi , Duan Lixia , Fang Chao , Liu Junjie , Zhang Kun , Luo Tao
Published: September 2022

Genetically arming new chimeric antigen receptors (CARs) on T cells is a prevalent method to fulfill CAR‐T immunotherapy. However, this approach fails to completely address the poor infiltration, complex immunosuppressive tumor microenvironment (ITM), and insufficient immune cells, which are recognized as the three dominant hurdles to discouraging the trafficking and persistence of CAR‐T and immune checkpoint blockade (ICB) immunotherapies against solid tumors. To address the three hurdles, a sonoimmunity‐engineered nanoplatform is designed in which a rattle‐type‐structured carrier enables intraparticle‐double‐scattering to generate massive reactive oxygen species (ROS) during the sonodynamic process. Abundant ROS accumulation can directly kill tumor cells, release antigens, and activate systematic immune responses for expanding effector T or CAR‐T cells, while alleviating ITM via immunosuppressive macrophage polarization and reduction in pro‐tumorigenic cytokine secretion. Furthermore, the co‐loaded phosphodiesterase‐5 inhibitors release nitric oxide (NO) to impel vascular normalization and open the infiltration barrier (IB) for allowing more T cells to enter into the tumor. Systematic experiments demonstrate the feasibility of such intraparticle‐double‐scattering‐decoded sonogenetics in the sonoimmunity‐engineered nanoplatforms for expanding effector T or CAR‐T cells, thereby promoting their infiltration into tumors and alleviating ITM. These compelling actions lead to excellent CAR‐T and ICB immunotherapies against solid tumors with repressed tumor metastasis.
Romiplostim use in pregnant women with immune thrombocytopenia
Authors: Bussel James B. , Cooper Nichola , Lawrence Tatiana , Michel Marc , Vander Haar Emilie , Wang Kejia , Wang Hongmei , Saad Hossam
Published: September 2022

Treatment for immune thrombocytopenia (ITP) in pregnancy is hampered by the lack of fetal safety evidence of maternally‐administered medications. The Pregnancy Surveillance Program (PSP) collected patient information from 2017–2020 for pregnancy, birth outcomes, and adverse events (AEs) for 186 women exposed to romiplostim from 20 days before pregnancy to the end of pregnancy. Timing of exposure was available in 128 women. Seventy‐one mothers (38%) had prepregnancy exposure to romiplostim; intrapartum exposure was known for the first (for many mothers when they discovered their pregnancy), second, and third trimesters for 74 (40%), 22 (12%), and 44 (24%) mothers, respectively, with 15 mothers exposed during >1 trimester. Among the 86 mothers with known pregnancy outcomes, 46 (53%) had at least one pregnancy‐related serious AE (SAE); approximately 2/3 of SAEs were due to underlying ITP. Of 92 mothers with known birth outcomes, 60 (65%) had a normal pregnancy and 16 (17%) had complications, with both categories including term and preterm births; there were 12 (14%) spontaneous miscarriages/stillbirths, 3 (3%) ectopic pregnancies, and 1 (1%) molar pregnancy. Most abnormal births resulted from abnormal pregnancies. There were five neonatal/postnatal AEs of note: inguinal hernia, cytomegalovirus infection, trisomy 8 (third trimester single‐dose romiplostim exposure), single umbilical artery without known anomalies, and development of autism at age 2 years. Seven of 12 infants with neonatal thrombocytopenia had resolution of thrombocytopenia before discharge; all 12 were discharged. Review of pregnancies in women exposed to romiplostim did not reveal any specific safety concerns for mothers, fetuses, or infants.
Review of genetic testing in kidney disease patients: Diagnostic yield of single nucleotide variants and copy number variations evaluated across and within kidney phenotype groups
Authors: Claus Laura R. , Snoek Rozemarijn , Knoers Nine V. A. M. , van Eerde Albertien M.
Published: September 2022

Genetic kidney disease comprises a diverse group of disorders. These can roughly be divided in the phenotype groups congenital anomalies of the kidney and urinary tract, ciliopathies, glomerulopathies, stone disorders, tubulointerstitial kidney disease, and tubulopathies. Many etiologies can lead to chronic kidney disease that can progress to end‐stage kidney disease. Despite each individual disease being rare, together these genetic disorders account for a large proportion of kidney disease cases. With the introduction of massively parallel sequencing, genetic testing has become more accessible, but a comprehensive analysis of the diagnostic yield is lacking. This review gives an overview of the diagnostic yield of genetic testing across and within the full range of kidney disease phenotypes through a systematic literature search that resulted in 115 included articles. Patient, test, and cohort characteristics that can influence the diagnostic yield are highlighted. Detection of copy number variations and their contribution to the diagnostic yield is described for all phenotype groups. Also, the impact of a genetic diagnosis for a patient and family members, which can be diagnostic, therapeutic, and prognostic, is shown through the included articles. This review will allow clinicians to estimate an a priori probability of finding a genetic cause for the kidney disease in their patients.
Surface modification of poly(propylene) fabric with graphene oxide‐based silver nanoparticles for antibacterial applications
Authors: Dat Nguyen Minh , Huong Le Minh , Tinh Ninh Thi , Linh Nguyen Thi Thuy , Hai Nguyen Duy , Viet Nguyen Duc , Thinh Doan Ba , Cong Che Quang , Dat Nguyen Tien , Phong Mai Thanh , Hieu Nguyen Huu
Published: September 2022

Herein, poly(propylene) (PP) was hydrophilized with oxidating agents and solvents, followed by dip‐coating with silver nanoparticles anchored GO sheets (Ag@GO) prepared by the in‐situ method as reported in our previous study to obtain silver@graphene oxide‐coated poly(propylene) (Ag@GO/PP). The impact of the modifying agents, dipping times, and coating concentrations on the antibacterial activities were studied accordingly via the inhibition zone method. The fabrics were re‐hydrophobized with the reduction of Ag@GO and the functionalization with stearic acid (SA) to form silver@reduced graphene oxide‐coated poly(propylene) (Ag@rGO/PP) and silver@graphene oxide/SA‐coated poly(propylene) (Ag@rGO‐SA/PP), respectively. Characterization of pretreated and modified PP samples was carried out by various modern analysis methods. Simultaneously, the cytotoxicity of the active layers, the release of Ag+ ions, and durability after washing were also investigated. The obtained results representing PP fabrics pretreated with HNO3/isopropanol and dipped in Ag@GO concentration of 2 g/L four times prove a sufficient approach for improving hydrophilization and bio‐compatibility for the PP samples. The fabrics greatly show an impressive interaction with precursors, mostly high antibacterial activity even after four washing cycles via appropriate releasing of Ag+ to ensure the safety in usage. They further suggest that the prepared fabrics could be utilized for actual application as a face mask.
Towards circular economy: A guiding framework for circular supply chain implementation
Authors: Amir Saman , Salehi Niloufar , Roci Malvina , Sweet Susanne , Rashid Amir
Published: September 2022

Closing the loop for resource efficiency is a well‐known practice in the industry. To concretize the circular economy implementation strategies, closed‐loop thinking requires innovation and adaptation. Circular supply chains (CSCs) are one of the key enablers in closing the loop by design or intention for value recovery and profit maximization. CSC is an emerging area, and the view of CSC where forward and reverse supply chain is seamlessly integrated with the overall aim to achieve system‐wide circularity is missing in the academic debate. By offering a cross‐functional perspective of CSC, this paper presents a CSC guiding framework to structure and understand the underlying complexities and highlight the crucial elements of the CSC implementation. Thus, this framework lays the basis for CSC within the systemic implementation of CE by closing the loop by design or intention. The framework categorizes the CSC into four building blocks, namely, systemic approach, main drivers, levels of decision making, and mechanisms to manage the full loop closure and minimize the inherent uncertainties of a complex system. The building blocks of the framework are synthesized from various streams of supply chain literature and recurring concepts in the circular economy literature. The CSC framework applicability is illustrated using two industrial cases that are transitioning towards the circular economy.
Inclusion of patients with chronic kidney disease in randomized phase 3 clinical trials in patients with prostate, breast, lung, and colorectal cancer
Authors: Delaye Matthieu , Rousseau Adrien , Try Mélanie , Massard Christophe , Campedel Luca , Hilmi Marc , Bagnis Corinne
Published: September 2022

The objective of this study was to determine the proportion of phase 3 clinical trials investigating a systemic therapy for patients with prostate, breast, lung, or colorectal cancer that excluded patients with Chronic Kidney Disease (CKD) and the exclusion criteria chosen, if any. A search was conducted using the ClinicalTrials.gov database to identify eligible studies. Of the 268 included trials, 185 (69%) had at least one renal exclusion criteria. Of these 185 trials, 116 (63%) had an undefined exclusion criterion. Only disease site was associated with exclusion of patients with CKD in the univariate analysis, but no factors in the multivariate analysis. There are several potential barriers to including patients with CKD in clinical trials. Nevertheless, solutions can be proposed to allow the inclusion of these patients. This would allow them to access to innovative therapeutic strategies, but also allow a better applicability of trial results to this patient population.
Real‐world data on lenalidomide dosing and outcomes in patients newly diagnosed with multiple myeloma: Results from the Canadian Myeloma Research Group Database
Authors: Mian Hira , LeBlanc Richard , Louzada Martha , Masih‐Khan Esther , McCurdy Arleigh , Venner Christopher P. , Stakiw Julie , Kardjadj Moustafa , Jimenez‐Zepeda Victor H. , Sebag Michael , White Darrell , Aslam Muhammad , Song Kevin , Reiman Anthony , Kotb Rami , Gul Engin , Reece Donna
Published: September 2022

Using the Canadian Myeloma Research Group Database, a retrospective study of 167 newly diagnosed, transplant‐ineligible patients with multiple myeloma (MM) that received lenalidomide‐dexamethasone as front‐line treatment was conducted to understand the impact of lenalidomide dosing. Starting dose modifications were common, 42% of patients started on lenalidomide <25 mg with normal renal function. During treatment course, 35% of patients required further dose reduction. Dose reductions in the first year did not have an impact on progression free survival or overall survival. Further studies need to be conducted to understand the impact of dosing strategies of anti‐MM agents in the real world.
Simulation Model for Digital Twins of Pneumatic Vacuum Ejectors
Authors: Stegmaier Valentin , Schaaf Walter , Jazdi Nasser , Weyrich Michael
Published: September 2022

Increasing productivity, as well as flexibility, is required for the industrial production sector. To meet these challenges, concepts in the field of “Industry 4.0” are arising, such as the concept of Digital Twins. Vacuum handling systems are a widespread technology for material handling in industry and face the same challenges and opportunities. In this field, a key issue is the lack of Digital Twins containing behavior models for vacuum handling systems and their components in different applications and use cases. A novel concept for modeling and simulating the fluidic behavior of pneumatic vacuum ejectors as key components of vacuum handling systems is proposed. In order to increase the simulation accuracy, the concept can access instance‐specific data of the used asset instead of object‐specific data. The model and the data are part of the Digital Twins of pneumatic vacuum ejectors, which shall be able to be combined with other components to represent a Digital Twin of entire vacuum handling systems. The proposed model is validated in an experimental test setup and in an industrial application delivering sufficiently accurate results.
Water Loss Predictive Tests in Flooded Lead‐Acid Batteries
Authors: Parnigotto Mattia , Mazzucato Marco , Fabris Daniele , Dainese Lorenzo , Cazzanti Silvia , Bortolamei Nicola , Durante Christian
Published: September 2022

Different aging processes rates of flooded lead–acid batteries (FLAB) depend strongly on the operational condition, yet the difficult to predict presence of certain additives or contaminants could prompt or anticipate the aging. Linear sweep current (LSC) and gas test (GT) characterizations were reported here to fasten the water consumption evaluation. The two methods were proposed to evaluate the water consumption effect at 60 °C, on a custom cell with a (1+ 2−) plate configuration. The predictive ability of the proposed tests was verified on 9 batches of plates for FLAB preliminary tested with the European standard CEI EN 50342‐1 : 2019‐11 method. LSC and GT tests showed the capability to identify plate batches with anomalous behaviour for the water consumption and good agreement with the European standard CEI EN 50342‐1 : 2019‐11 method. Furthermore, it was found that Tafel parameters determined from LSC and GT tests correlated well with the concentration of Te.
Distribution of potassium during chemical activation of petroleum coke: Electron microscopy evidence and links to phase behaviour
Authors: Montes Vicente , Xiao Ye , Wu Jingfeng , Hill Josephine M.
Published: September 2022

In this study, direct evidence for chemical penetration into petroleum coke particles during activation is presented. In addition, the porosity development was directly related to the sulphur loss and phase behaviour of the species present. Petroleum coke (petcoke, 6 wt.% sulphur) was activated with KOH and NaOH at temperatures between 400 and 800°C. The CS bonds were broken before 400°C in the presence of KOH and before 500°C in the presence of NaOH. Electron microscopy analysis of cross‐sectioned and ultramicrotomed samples revealed that sulphur was still present within the particles and that the hydroxide activation agents had penetrated to the centre of the particles (90–150 μm). After heating to 800°C and washing with a weak acid aqueous solution, essentially all the sulphur was removed, as was any remaining chemical agent. The characterization results, phase diagrams, and complementary experiments with carbonate chemical agents or steam suggest that, during heating, a molten phase formed around the petcoke particles. The composition of this molten phase changed as activation proceeded and both sulphur and ash components were liberated from the petcoke. This better understanding of the activation process will improve the efficiency of preparing activated carbon.
Construction of a High‐Quality Organic‐Inorganic Hybrid Heterostructure and Its Photo‐response Performance
Authors: Zhang Yadan , Yu Guanghua , Xue Di , Lu Jie , Meng Xing , Yin Yao , Wang Qi , Wang Zi , Huang Lizhen , Chi Lifeng
Published: September 2022

Comprehensive Summary

The combination of metal oxide and organic semiconductor for constructing organic–inorganic hybrid heterostructure is promising to offer unique optoelectronic properties. However, the distinct difference in electron structure and processing technology of the two types of materials makes it usually difficult to fully deliver their complementary advantages. Herein, we report the construction of a high quality organic/In2O3 hybrid heterostructure presenting a good ambipolar transport with average electron mobility >1 cm2·V–1·s–1 and hole mobility up to 0.4 cm2·V–1·s–1, respectively, together with a high‐gain inverter. In addition, the incorporation with organic film on top of In2O3 remarkably reduces the dark current, enabling the realization of high photoconductivity response with photosensitivity of two magnitudes higher than that of pure In2O3. The photoconductor and phototransistor of the hybrid structure demonstrate high photoresponsivity >103 AW–1 and detectivity up to 1014 Jones, demonstrating the promising functionality of such a high quality hybrid heterostructure.
Mobile health app for monitoring allergic rhinitis and asthma in real life in Lithuanian MASK‐air users
Authors: Kvedarienė Violeta , Biliute Gabija , Didziokaitė Gabija , Kavaliukaite Loreta , Savonyte Agne , Rudzikaite‐Fergize Gabija , Puronaite Roma , Norkuniene Jolita , Emuzyte Regina , Dubakiene Ruta , Valiulis Arunas , Sousa‐Pinto Bernardo , Bedbrook Anna , Bousquet Jean
Published: September 2022

Background

MASK‐air® is an app whose aim is to reduce the global burden of allergic rhinitis (AR) and asthma. A transfer of innovative practices was performed to disseminate and implement MASK‐air® in European regions. The aim of the study was to examine the implementation of the MASK‐air® app in Lithuanian adults in order to investigate (i) the rate of acceptance in this population, (ii) the duration of app use and (iii) the evaluation of the app after its use.

Methods

In a longitudinal study, Lithuanian adults with AR and/or asthma were recruited by allergists. They were informed about how to use MASK‐air® and were followed closely. They were reviewed after one to 3 months to evaluate satisfaction and were asked to continue using the app.

Results

Among the 149 patients recruited (37.2 ± 10.4 years), 52.4% had rhinitis alone, 42.9% had rhinitis, asthma and/or conjunctivitis multimorbidity, and 2.7% isolated asthma. According to the MASK‐air® baseline questionnaire, 88.3% of patients considered that their symptoms were troublesome. Data were available for 102 (68.4%) patients. The duration of app usage in patients ranged from 1 to 680 days (median, 25–75 percentile: 54, 23.2–151 days). Forty‐two (41.1% of patients who were reviewed) patients agreed to share their opinion on MASK‐air®. Most users of the app were satisfied, from 46.5% thinking their allergy was treated more successfully to 90.4% recommending this app to other allergy sufferers.

Discussion

When recommended by physicians, MASK‐air® was used for a longer period of time.
Type 1 vomeronasal receptors expressed in the olfactory organs of two African lungfish, Protopterus annectens and Protopterus amphibius
Authors: Nakamuta Shoko , Yamamoto Yoshio , Miyazaki Masao , Sakuma Atsuhiro , Nikaido Masato , Nakamuta Nobuaki
Published: September 2022

Lungfish are the fish related most closely to tetrapods. The olfactory organ of lungfish contains two distinct sensory epithelia: the lamellar olfactory epithelium (OE) and the recess epithelium (RecE). Based on their ultrastructural and histological characteristics, the lamellar OE and the RecE are considered to correspond respectively to the teleost OE and a primitive vomeronasal organ (VNO). In tetrapods, the OE and VNO have been shown to express different families of olfactory receptors; for example, in mammals, the OE expresses odorant receptors and trace amine‐associated receptors, while the VNO expresses type 1 (V1Rs) and type 2 (V2Rs) vomeronasal receptors. In the present study, we examined the expression of V1Rs in the olfactory organs of two African lungfish, Protopterus annectens and Protopterus amphibius. RNA sequencing and phylogenetic analyses identified 29 V1R genes in P. annectens and 50 V1R genes in P. amphibius. Most V1Rs identified in these lungfish were classified as the tetrapod‐type V1Rs initially found in tetrapods and distinct from fish‐type V1Rs. In teleost, which all lack a VNO, all olfactory receptors are expressed in the OE, while in Xenopus V1Rs are expressed exclusively in the OE, and not in the VNO. In situ hybridization analysis indicated that lungfish V1Rs were expressed mainly in the lamellar OE and rarely in the RecE. These results imply that V1R expression in lungfish represents an intermediate step toward the complete segregation of V1R expression between the OE and VNO, reflecting the phylogenetic position of lungfish between teleosts and amphibians.