bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Pemakaian Gadget Terhadap Perilaku Sosial Siswa di Sekolah Dasar Negeri Taal 01 Kecamatan Tapen Kab. Bondowoso
Authors: Prayuda Rio Aditya , Munir Zainal , Siam Wiwin Nur
Published: March 2021

The use of gadgets is one of the electronic media that influences social behavior, especially in absorption in interacting with social values. This study aims to analyze the Effects of the Use of Gadgets on Social Behavior of Students in Taal 1 Primary School, Tapen District, Bondowoso Regency. The research design used was analytic with cross sectional approach. The population was students and a sample of 38 students consisted of classes III, IV, and V of Taal 1 Elementary School, Tapen District, Bondowoso District with a total sampling method. Data was collected using a questionnaire, then the data was tabulated and analyzed using Spearman Rho statistical correlation analysis with a significance level of 0.05, so that a p <value of 0.004 was obtained, which means that H1 was accepted. Bondowoso. The importance of knowledge about the use of gadgets on social behavior of students, so children need the role of teachers and parents to prevent negative social behavior Keywords: Use of gadgets, social behavior
Hubungan Kepatuhan Minum Tablet Fe dengan Kejadian Anemia (Hb) pada Remaja Putri Di SMP Negeri 1 Tapen Kabupaten Bondowoso
Authors: Putra Kristiyan Adi , Munir Zainal , Siam Wiwin Nur
Published: March 2021

Anemia often occurs in young women because in adolescence there has been rapid growth into the age of puberty including red blood cells will increase. In addition, in young women, menstrual cycles begin to occur that will release blood from the body with a considerable amount. One effort that can be done is to consume Fe tablets.The research design is a quantitative method in the form of Cross Sectional Design. The study was conducted on Class VII Adolescent Girls in Junior High School 1 Tapen - Tapen, Bondowoso in May 2019 with a sample of 33 respondents. The measuring instrument used was a questionnaire sheet which then carried out the Spearman Rho analysis test with a significance level of p≤ 0.05. The results obtained p-value 0.007 (P≤ 0.05). So Ho was rejected and H1 was accepted, so there was a correlation between the Compliance of consumption Fe tablets with the incidence of Anemia in Class VII Adolescent Girls in Junior High School 1 Tapen, Tapen, Bondowoso. There is a need for counseling on the importance of consumption of Fe tablets and collaboration with teachers regarding the consumption of Fe tablets. Keywords: Fe Tablet Consumption, Compliance, Incidence of Anemia
Hubungan Komunikasi Terapeutik Dengan Kepuasan Pasien Rawat Inap Puskesmas Tapen Kabupaten Bondowoso
Authors: Hidayatullah Mohammad Syarif
Published: March 2021

Therapeutic communication is very important for the image of the nursing profession and the image of the hospital. Communication that occurs at the Tapen Puskesmas is still ineffective, so misunderstandings between nurses and patients often occur. The purpose of this research is to find out. The relationship between therapeutic communication with inpatient patient satisfaction at Tapen Health Center in Bondowoso Regency and to find out how big is the relationship between Therapeutic Communication and Patient Satisfaction in the Inpatient Room at Tapen Health Center in Bondowoso Regency. This research method is quantitative. This research was conducted in May 2019 with a sample of 30 inpatients. The sampling technique uses total sampling where the p-value has a significant relationship and Ha is received between therapeutic communication and patient satisfaction. The results of this study indicate that the relationship between Therapeutic Communication Nurse with Inpatient Satisfaction in Tapen Health Center, Bondowoso Regency, a significant relationship between therapeutic communication with inpatient satisfaction. The level of therapeutic communication relationship with patient satisfaction.
Hubungan Kualitas Pelayanan Rawat Inap Dengan Indeks Kepuasan Masyarakat Puskesmas Wonosari
Authors: Mulyati Lilik
Published: March 2021

Community satisfaction measurements are intended to determine the level of community satisfaction with the services provided and provide an opportunity for the community to assess the services that have been received.The design of this study is quantitative with a Cross-Sectional approach. The study was conducted by involving 59 respondents taken by accidental sampling. The study was conducted in April until May 2019 at Wonosari Health Center, Bondowoso Regency. The measuring instrument used was a questionnaire, then bivariate analysis was performed with Spearman Rank Analysis, with a significance of p = 0.05. The results of the Spearman Rank statistical test with significance levels p <0.05. Obtained p-value 0,000 which means There is a Relationship between the Quality of Inpatient Services and the Wonosari Community Health Center Community Satisfaction Index with a correlation coefficient of 0.714. The quality of inpatient care results in an index of community satisfaction when receiving health services provided. The quality of this service can ultimately provide several benefits, including the establishment of harmonious relationships between service providers and customers, providing a good basis for creating customer loyalty and building a favorable recommendation for these service providers.
HUBUNGAN KOMUNIKASI TERAPEUTIK DENGAN TINGKAT KECEMASAN PASIEN BARU di RUANG UGD PUSKESMAS TAMANAN BONDOWOSO
Authors: Novita Rini
Published: March 2021

One of the emotional problems disorders that are often encountered and has a psychological impact seriously is anxiety. Anxiety is an unclear and diffuse concern related to feelings of uncertainty and helplessness. Anxiety is an emotional experience that is short-lived and reasonable response, when individuals faceup pressure or events that threaten their lives, both internal and internal threats. Anxiety that happened and hav a relation ship with medical condition often found when patient came to healt hfacility, whichone of themisemergencyroom. Therapeutic communication methods provide understanding between nurses and patients with the aim of helping patients clarify and reduce the burden of the mind and are expected to eliminate anxiety. This study aims to knowabout relationship between therapeutic communication and the anxiety level of new patients.This study useddescription korelation with cross sectional approach. Sample are171 people. Instrument used for data collection is the questionnaire, anddata analysis used the Spearman Rho test. Therapeutic communication of nurses was mostly in good categorywas128 respondents (74.9%). The anxiety level of new patients is not anxious categorywere 127 respondents (74.3%). Rho Spearman's test results obtained a coefficient (r) of 0.901 with a p value of 0,000. Because p<0.005 then H0 is rejected.Conclusion,There is a significan trelation ship between therapeutic communication and the anxiety level of new patients in the emergency room at Tamanan Bondowoso Public Health Center.
PERSEPSI KLIEN TERHADAP FAKTOR-FAKTOR YANG MEMPENGARUHI PEMANFAATAN LAYANAN RAWAT JALAN DI PUSKESMAS KLABANG KABUPATEN BONDOWOSO
Authors: Maghfiroh Wilda
Published: March 2021

Health services is most closely related to when someone needs health services and how far the effectiveness of these services. This study aims to analyze the factors that influence clients in utilizing outpatient services at Klabang Community Health Center, Bondowoso District. Quantitative research design with a Cross. With a sample of 245 respondents taken with accidental sampling technique. The tool used was a questionnaire, which then carried out a bivariate and multivariate analysis to determine the factors that influence the client in the use of outpatient services at the Klabang Community Health Center in Bondowoso district. The results of the statistic test found that service facilities, nurse or midwife services, service fees, doctor services, ease of information and health insurance regulation systems significantly affected the utilization of outpatient services. Community perceptions of good service from the community health center give a deep impression and cause motivation to be able to take advantage of the health services provided. If the public knows that service delivery is by what is expected, trust and satisfaction will increase. The Public Health Center as one type of first-level health service facility has an important role in the national health system, specifically the health efforts subsystem.
HUBUNGAN KONSEP DIRI DENGAN EFIKASI DIRI PADA PASIEN TB PARU DI WILAYAH KERJA PUSKESMAS WONOSARI
Authors: Suryalaga Yogi Ludirta
Published: March 2021

Pulmonary TB and Self Concept are two things that influence each other both directly and indirectly. Pulmonary TB is a disease that affects not only physical health, but also the psychological (mental) and social conditions. At the physical level in the form of self-concept because of daily activities, handling symptoms and treatment. At the psychological level, self-concepts include rejection, worry and stigma about infectious diseases. Physical and emotional conditions determine how a person evaluates his abilities. Self-efficacy in pulmonary TB patients focuses on being able to carry out behaviors that support disease improvement and self-care management such as being able to breathe deeply, cough effectively and adhere to pulmonary TB treatment. This study aims to identify the relationship between self-concept and self-efficacy in pulmonary TB patients in the work area of Wonosari Health Center, Bondowoso Regency. The measuring instrument used was a questionnaire, then bivariate analysis was performed with Spearman Rank Analysis, with a significance of p = 0.05. The results of the Spearman Rank statistical test with significance levels p <0.05. Obtained p value 0.002 which means that Ho is rejected and H1 is accepted, There is a Relationship between Self Concept and Self Efficacy in patients with Pulmonary TB in the Wonosari Health Center work area with a correlation Coefficient level of 0.311. then nurses need to examine the problem of self-concept and self-efficacy to determine appropriate self-concept management interventions and to improve the self-efficacy of pulmonary TB patients and it is expected that future nurses can provide comprehensive nursing care and give more attention to the principle of health promotion through the provision of health education pulmonary TB treatment and provide motivation so that pulmonary TB patients still have the enthusiasm to recover in undergoing treatment to completion.
HUBUNGAN PEMAHAMAN PESAN KEHAMILAN DAN KEPATUHAN KUNJUNGAN ANTENATAL DENGAN KEPATUHAN KONSUMSI TABLET TAMBAH PADA IBU HAMIL TRIMESTER III DI WILAYAH PUSKESMAS TLOGOSARI
Authors: Maula Hikmatul , Trilianto Arif Eko , Shidiq Pasidi
Published: March 2021

One of the health servicestrategies to improve the understanding of pregnant women is the maternal and Child Health (MCH) book. The MCH Handbook is communication tool that contains message on maternal and child health. The massagein the KIA book includes massage for the period of pregnancy that are things that need to be done by pregnant women as wellas the addition of body suplements suct as tables plus blood. Research design utilized in this study is corelasional with statistical Chi Square test and Multiple Regression Analysis with 46 people function as sample. The sampling technique which is used non-probability sampling. Data collection is done by questionnaire and obsevation (check list). Result of this study shows that (1) there has been significant correlation between the understanding of pregnancy suggestion and the obedience of consuming increment tablet with significant level P = 0,038 < 0,05, (2) there has also been crucial correlation the obedeance of antenatal visit and the obedience of consuming increment tablet with significant level P = 0,00 < 0,05 and (3) there has been inportant correlation among the understanding of pregnancy suggestion the obedeance of antenatal visit and obedience of consuming increment tablet with significancy level 0,000 < 0,05 with consequently H0 is rejected and H1 is accepted.Herefore, it needs to be improved abaut the use of the MCH handbook and the role of health workers in increasing adherence to antenatal visits so that compliance with the consumpsion of blood tablet supplements for pregnant woment can increase
Hubungan Tingkat Pengetahuan Dengan Sikap Keluarga Penderita Demam Berdarah Dengue Tentang Pemberantasan Sarang Nyamuk (PSN) Di Wilayah Kerja Puskesmas Curahdam
Authors: Susanti Riska Dewi Dian , Hefniy Hefniy , Agustin Yuana Dwi , Nugroho Setyo Adi
Published: March 2021

Dengue Hemorrhagic Fever (DHF) is also one of the infectious diseases that often cause extraordinary events. Low awareness to maintain environmental cleanliness and lack of public knowledge about eradicating mosquito nests to prevent Dengue Hemorrhagic Fever. This study aims to identify the relationship between the level of knowledge and the family attitudes of dengue hemorrhagic fever sufferers regarding the eradication of mosquito nests (PSN) in the work area of the Curahdami Health Center in Bondowoso Regency.Types of quantitative research designs. population and sample of 37 respondents by using total sampling. Data collection techniques used the Likert scale questionnaire to measure Knowledge Level and bivariate analysis was performed to determine the relationship between variables using Spearman's Rho. Statistical test results of Spearman's Rho. Obtained p-value 0.002 which means that Ho is rejected and H1 is accepted. There is a relationship between the level of knowledge with the family attitudes of dengue hemorrhagic fever sufferers about the eradication of mosquito nets in the work area of the bulk health center with a correlation coefficient of 0.487.From the results of this study, the level of knowledge of families suffering from dengue fever in eradicating mosquito nests in the Bondowoso district health center area is good.
Hubungan Obesitas Remaja Dengan Gambaran Citra Tubuh Di MTSN 1 Bondowoso Desa Traktakan Kecamatan Wonosari
Authors: Lestari Siti Rahmi , Trilianto Arif Eko , Siddiq Pasidi
Published: March 2021

Obesity is a problem which is scared by all ages, including juvenile ages because it can affect the change in physical appearance.A change in physical appearance certainly can influence their body image in juvenile age. The objective of the study is correlation between juveniles obesity ang body image in student of MTsN I Bondowoso at Traktakan Village Wonosari districts.This study is kuantitatif research, the population is all of students from MTsN I BondowosoTraktakan village Wonosaridistricts.a sample 28 ( twentyeigh) people, sampling using proposive sampling, data analysis using the Spearman Rho. The score of correlation test showed from SPSS 17  that the Spearman Rho value p < 0,05 can to correlation value p = 0,040 value p = 0,040 is smaller than 0,05,and r = 0,391 which means the hypothsis is accepted.The result of this research found that there was significentcorrelation between juvenile obesity and body image in students of MTsN I Bondowoso. From the resultof this study,researchers are looking forward to a change in adolescent to diet and exercise activities that routine to maintain ideal body weight
Faktor-Faktor Yang Berhubungan Dengan Peningkatan Kasus Stunting Pada Balita Di Kabupaten Probolinggo
Authors: Munir Zainal , Kholisotin Kholisotin , Hasanah Ayu Masrurotul
Published: March 2021

Stunting is the upcoming of indeks condition in the higher level that is based on the age. minus and standar devision according to WHO. Stunting is manifestation with no limition factor of the diet consumer. Who has low quality and also the protein in the growing up development it is started since first life. Planing observation to find factor relation between the case of stunting development since baby in probolinggo regency. This quantitative observation to close sectional cross with sampel election by using random sampling those are 52 respodens. Based on analyze of data that is used by univariat analisa, bivariat usage based on chi square uji. As the result of this observation those are : (1) the relation of mother protein with the improvementof stunting case for the baby with p value 0,003<0,05. (2) the relation of upbringing of stunting case for baby in p value : 0,002<0,05. (3) the relation of economic factor in upbringing stuntinnf case for baby with p value 0,004<0,05 in summary : bored on the relation between variable and stunting case of baby, government observation in society in the healthy instansi job to obigate and practice based of the schedule which given in every groups. This about the importance of protecting dtunting from now.and also it can be more spesific for mother in protecting stunting from now and give more protein for the son to make e qucil.
Clinical features, pathogenesis and treatment of long-haul COVID‑19 impact on nervous system
Authors: Barinov A. N. , Moshkhoeva L. S. , Parkhomenko E. V. , Emikh E. V. , Yastrebtseva I. P.
Published: March 2021

The current outbreak of coronavirus SARS-CoV‑2 (COVID-19) has raised great concern worldwide, but its impact on nervous system still needs more investigation. Thirty per cent of symptomatic patients with COVID‑19 will have symptoms that last longer than the typical two weeks, 10 % have symptoms longer than 3 months and this is called ‘long-COVID’. These symptoms affect not only people with severe disease, but also those with milder cases. Many long-haulers experience the same symptoms they had during their initial fight with COVID‑19, such as fatigue, cognitive impairment (or brain fog), difficulty breathing, headache, depression, insomnia and loss of the sense of taste and\or smell. Treatment of those complications with citicoline, ethylmethylhydroxypyridine succinate and vitamin B improves these symptoms in patients but most of them also need cognitive therapy for dehypochondrisation.
Personality traits, emotional disorders and adaptation of elderly men and women with chronic cerebral ischemia
Authors: Abramenko Yu. V. , Slyusar I. N. , Slyusar T. A.
Published: March 2021

Objective. To conduct a comparative analysis of personality traits, emotional disorders and adaptation of elderly men and women in the early stages of chronic cerebral ischemia (CCI).

Material and methods. We examined 120 patients with early manifestations of CBI – 48 men and 72 women (mean age is, respectively, 64.3 ± 0.5 and 65.0 ± 0.6 years). The study of personality traits was carried out using the method of multifactorial personality research of R. Kettell. Emotional disorders were identified according to ICD-X criteria, insomnia according to ICDS‑2 criteria. The level of general asthenia was assessed according to the MFI‑20 scale, anxiety according to the Spielberger scale, depression according to the Beck questionnaire, the quality of sleep according to the questionnaire of the Federal Somnological Centre. The type of adaptive reactions was determined in the leukocyte blood count by the percentage of lymphocytes and segmented neutrophils, taking into account the representation of other blood cells.

Results. Emotional and insomnia disorders predominated among women with CCI. Female patients were characterized by higher levels of excitation, tension and anxiety compared to men. Male patients were superior to women in terms of emotional balance. According to the analysis of leukograms, unfavorable adaptive reactions (overactivation and chronic stress) were significantly more frequent in women and correlated with a high level of anxiety and depression. The findings may have implications for the individualization of therapeutic interventions.
Sleep disorders in doctors in the context of the COVID-19 pandemic
Authors: Korabelnikova E. A. , Vorobieva O. V. , Makarov S. A. , Danilov A. B.
Published: March 2021

Study. The relationship of sleep disorders with anxiety in practicing neurologists in the context of a pandemic. Goals. To assess the quality of sleep, the level of anxiety and their mutual influence in neurologists.

Design. 330 neurologists were interviewed using the GoogleForms service, using the questionnaire "The psychological impact of the coronavirus pandemic on the population is measured using the Psycho-Covid‑19 questionnaire" in partnership with an international group of researchers led by VitoTummino and Dr. FrancoVimercati (Italy).

 Results. Sleep disorders ranging from mild to very severe were detected in 35% of respondents, which indicates that they have a high risk of insomnia. A statistically significant positive correlation of sleep disorders with both the overall indicator of psychological risk and the possibility of developing psychopathological syndromes is shown. Conclusion. The detection and correction of sleep disorders is important as a preventive measure and for the correction of anxiety disorders in medical professionals.
Clinical and neuroimaging features of chronic cerebral ischemia in polycythemia vera
Authors: Zyrina G. V. , Slyusa T. A.
Published: March 2021

The purpose of the study. To study clinical and neuroimaging features of chronic cerebral ischemia (CCI) in polycythemia vera (PV).

Materials and methods. 66 patients with PV were examined – the main group (43 men, 23 women; mean age 62.0 ± 3.4 years), of which 64 (97.0%) patients were diagnosed with CCI. The comparison group consisted of 85 patients with CCI (34 men, 51 women; mean age 67.7 ± 4.6 years), who developed against the background of cerebral vascular atherosclerosis and arterial hypertension. To identify cognitive disorders, we used Mini Mental State Examination (MMSE). Insomnia was studied in accordance with the criteria of the International Classification of Sleep ICDS‑22005. The quality of sleep was determined using a questionnaire from the Federal Somnological Center. Neuroimaging (MRI of the brain) was performed on Siemens Symphony 1.5 T and GE Signa 1.5 T tomographs.

Results. Subjective symptoms CCI are characterized by a greater representation of asthenic and insomniac disorders. Transient ischemic attacks in patients with PV are significantly more common than in the comparison group, their frequency depends on the duration of PV. The revealed changes in MRI of the brain in the majority of PV patients with CCI are characteristic of multiinfarction vascular encephalopathy; in the comparison group, changes that characteristic for subcortical arteriosclerotic encephalopathy were more often recorded.
Video laparoscopic diagnostics and surgical tactics for acute diseases of abdominal organs
Authors: Ermolov A. S. , Samsonov V. T. , Yartsev P. A. , Gulyaev A. A.
Published: March 2021

The article presents the results of video laparoscopy (VLS) performed in 2008–2019 in 5,599 patients in order to diagnose acute diseases of the abdominal organs requiring emergency surgery, identify competing and concomitant diseases, and determine treatment tactics. 2,442 (43.6 %) of them made up group I, with no doubt; 2,656 (47.4 %) – II group, with presumptive reliability; and 501 (9.0 %) – group III, with an unclear clinical diagnosis of the disease. In 2,326 (95.2 %) patients of group I with VLS, the clinical diagnosis was confirmed, in 100 (4.1 %) other diseases were revealed, and in 16 (0.7 %) the diagnosis was not established. Competing diseases were found in 8 patients and concomitant diseases in 4. In 1,641 (61.8 %) patients of group II, VLS made it possible to clarify and differentiate the clinical diagnosis of diseases, in 929 (35.0 %) – to identify other diseases, and in 86 (3.2 %) the diagnosis was not possible. When performing differential diagnosis, 126 other diseases were identified more than the number of patients. Competing diseases were found in 6 patients and concomitant diseases in 6 patients. 356 (71.0 %) patients of group III with VLS were diagnosed with major diseases, 75 (15.0 %) had other diseases, and 70 (14.0 %) were not diagnosed. In 4 patients, competing diseases were found, and in 1 – concomitant disease. Of the 5,427 (96.9 %) patients with the definitive diagnosis of the disease established with VLS, 3,828 (70.5 %) were found to be able to perform VLS operations, in 10 (0.3 %) of them – simultaneous with competing diseases.
Main approaches to treatment of hypoxia in acute respiratory distress syndrome, bacterial and viral pneumonia (part II)
Authors: Vlasenko A. V. , Evdokimov E. A. , Rodionov E. P.
Published: March 2021

The paper summarizes data on modern approaches to the diagnosis, prevention and treatment of severe acute parenchymal respiratory failure of various origins, including ARDS due to bacterial viral pneumonia. The work is based on the data of modern well-organized studies, analysis of international clinical guidelines with a high degree of evidence, as well as the results of our own long-term experimental studies and clinical observations of the treatment of patients with ARDS of various origins, including viral pneumonia of 2009, 2016, 2020. Scientifically grounded algorithms for prevention, differential diagnosis and personalized therapy of severe acute respiratory failure using innovative medical technologies and a wide range of respiratory and adjuvant treatment methods have been formulated. The authors tried to adapt as much as possible the existing current recommendations for the daily clinical practice of anesthesiologists and resuscitators.
Main approaches to treatment of hypoxia in acute respiratory distress syndrome, bacterial and viral pneumonia (part III)
Authors: Vlasenko A. V. , Evdokimov E. A. , Rodionov E. P.
Published: March 2021

The paper summarizes data on modern approaches to the diagnosis, prevention and treatment of severe acute parenchymal respiratory failure of various origins, including ARDS due to bacterial viral pneumonia. The work is based on the data of modern well-organized studies, analysis of international clinical guidelines with a high degree of evidence, as well as the results of our own long-term experimental studies and clinical observations of the treatment of patients with ARDS of various origins, including viral pneumonia of 2009, 2016, 2020. Scientifically grounded algorithms for prevention, differential diagnosis and personalized therapy of severe acute respiratory failure using innovative medical technologies and a wide range of respiratory and adjuvant treatment methods have been formulated. The authors tried to adapt as much as possible the existing current recommendations for the daily clinical practice of anesthesiologists and resuscitators.
Role of pharmaco- and micronutrients in nutritional metabolic therapy of COVID-19 and other viral infections
Authors: Dmitriev A. V. , Machulina I. A. , Shestopalov A. E.
Published: March 2021

Malnutrition is an unfavorable background for the course and outcome of viral diseases, including COVID-19. In accordance with international recommendations, timely correction of nutritional status using oral, tube enteral and parenteral nutrition is a necessary and mandatory method of concomitant therapy for COVID-19. An analytical review of the results of studies on the clinical use of pharmacological nutrients (glutamine; vitamins A, C, D, E; zinc, selenium) for the prevention and treatment of viral infections, including COVID-19, was performed. According to the data of clinical studies carried out in 2019–2020, the use of glutamine and antioxidant micronutrients as part of nutritional metabolic therapy can reduce the severity of clinical symptoms and accelerate the recovery process of patients with the new coronavirus infection COVID-19 and other viral diseases. From a practical point of view, the only sources of glutamine for enteral administration registered in the Russian Federation are Glutamine Plus for oral enteral nutrition and Intestamin for enteral tube administration and Dipeptiven 20% for parenteral nutrition. The use of pharmacological nutritional therapy, in particular, enteral or parenteral glutamine as a component of clinical nutrition in patients with viral infections and nutritional deficiency or the risk of its development, helps to improve clinical results, reduce the severity of the disease and accelerate the rehabilitation process.
Early invasive tactics for treatment of patients with various forms of unstable angina
Authors: Gazaryan G. A. , Zakharov I. V. , Ermolov A. S.
Published: March 2021

The paper presents immediate and long-term results of early invasive treatment tactics in 467 patients with various forms of unstable angina (UA), including 129 patients with unstable rest angina, 225 patients with unstable exertional angina, and 93 patients with a new onset angina. Percutaneous coronary interventions on a symptom-affected artery at a single procedure were performed in 213 cases (48%), indications for coronary artery bypass grafting were identified in 182 patients (41%), and only in 52 cases (11%) the treatment was limited to medicinal therapy. Coronary angiography performed in the initial 12–48 hours makes it possible to identify the indications to myocardial revascularization, to avoid inconsistencies in the choice of optimal treatment tactics and non-invasive risk assessment.
1365 İskenderiye Baskını
Authors: AKYURT Songül
Published: March 2021

Öz

Mısır, Suriye, Hicaz ve Güneydoğu Anadolu’da hüküm süren Memlûk Devleti tıpkı selefi Eyyûbîler gibi Haçlıların izlerini Müslüman topraklardan silmek amacıyla onlara karşı cihatı kendilerine vazife bildi. 1291 yılında Akkâ’yı Haçlılardan geri alan Sultan el-Eşref Halil, aynı hızla Saydâ ve Beyrut’u da ele geçirdi. 1291 yılında Akkâ’nın Memlûkler tarafından ele geçirilmesi Haçlıların Memlûk topraklarındaki ticari faaliyetlerini sekteye uğrattı. Haçlılar hem kaybettikleri toprakları geri almak hem de Memlûk Devleti’nden intikam almak amacıyla harekete geçtiler. Bu çalışmada, henüz on yaşında iken tahta oturtulmuş Sultan el-Melik el-Eşref Şaban döneminde Memlûklerden intikam almak amacıyla gerçekleştirilmiş olan İskenderiye baskınından ve bu elim saldırının devlete uzun soluklu etkilerinden bahsedilecektir.

Anahtar Kelimeler: Mısır, Memlûk Devleti, Sultan Şaban, Haçlılar, İskenderiye Baskını.

ABSTRACT

The Mamluk State, which ruled in Egypt, Syria, Hejaz and South eastern Anatolia, just like its predecessor Ayyubids, took the jihad against the Crusaders in order to erase the traces of them from the Muslim lands. Sultan el-Ashraf Halil, who took Akkâ back from the Crusaders in 1291, also captured Saydâ and Beirut with the same speed. The capture of Akkâ by the Mamluks in 1291 disrupted the Crusaders' commercial activities in the Mamluk lands.The Crusaders took action both to reclaim their lost lands and to take revenge on the Mamluk State. This study, will focus on the Alexandria raid, which was carried out in order to take revenge on the Mamluks during the reign of Sultan al-Malik al-Ashraf Shaban, who was enthroned at the age of ten, and the long-lasting effects of this attack on the state.

Keywords: Egypt, Mamluk State, Sultan Shaban, Crusaders, Alexandria Raid.
Economic and legal instruments for the realization of foreigndirect investment in infrastructure sectors of the economy
Authors: Marіana Orshanska
Published: March 2021

The purpose of the article is to determine the nature, characteristics and keyproblems of the main types of economic and legal instruments for the realizationof foreign direct investment (FDI). the methodological basis of the study is asystematic approach to the processing and compilation of statistics and indicators,as well as methods for their comparison, analysis and synthesis and a method offorecasting decisions on the use of investment potential to increase the attractivenessand volume of FDI attraction. The scientific novelty of the research lies in theanalysis of greenfield and brownfield strategies as the main forms of FDIimplementation, the disclosure of the content and interpretation of data on thereal state of FDI attraction, the search for opportunities to improve the investmentclimate and effective mechanisms for attracting foreign investors. conclusions. Itis confirmed that the investment attractiveness and rating of the country in theinternational market are the main factors for attracting investors. Inaccessibleinfrastructure, inefficient judicial system, high level of corruption and imperfectlegislation are the main obstacles that need to be overcome in order to attractforeign investors’ funds, providing a full package of assistance and support ateach stage of the implementation of investment projects. Greenfield and brownfield(M&A) are the most effective forms of FDI in order to achieve high growth ratesof the domestic economy, improve the level of population well-being andinternationally enter Ukraine. An analysis of the statistics on the effectiveness ofinnovative enterprise development projects, the characteristics of economic andlegal instruments indicate the gradual improvement of the investment climate andthe promotion of FDI inflows into the region’s economy through the implementationof greenfield and brownfield strategies. Examples of effective implementation ofthese strategies in the creation of new enterprises, companies of foreignrepresentation, which are expanding their capacity and entering new domesticmarkets are given. Examples of the brownfield strategy have been analyzed torestart existing and high-quality structural and organizational changes in inefficiententerprises, which have given impetus to improving the economic environment,investment attractiveness of the economy of the region and the country as a whole.
Modeling Type 1 Diabetes Using Pluripotent Stem Cell Technology
Authors: Joshi Kriti , Cameron Fergus , Tiwari Swasti , Mannering Stuart I. , Elefanty Andrew G. , Stanley Edouard G.
Published: April 2021

Induced pluripotent stem cell (iPSC) technology is increasingly being used to create in vitro models of monogenic human disorders. This is possible because, by and large, the phenotypic consequences of such genetic variants are often confined to a specific and known cell type, and the genetic variants themselves can be clearly identified and controlled for using a standardized genetic background. In contrast, complex conditions such as autoimmune Type 1 diabetes (T1D) have a polygenic inheritance and are subject to diverse environmental influences. Moreover, the potential cell types thought to contribute to disease progression are many and varied. Furthermore, as HLA matching is critical for cell-cell interactions in disease pathogenesis, any model that seeks to test the involvement of particular cell types must take this restriction into account. As such, creation of an in vitro model of T1D will require a system that is cognizant of genetic background and enables the interaction of cells representing multiple lineages to be examined in the context of the relevant environmental disease triggers. In addition, as many of the lineages critical to the development of T1D cannot be easily generated from iPSCs, such models will likely require combinations of cell types derived from in vitro and in vivo sources. In this review we imagine what an ideal in vitro model of T1D might look like and discuss how the required elements could be feasibly assembled using existing technologies. We also examine recent advances towards this goal and discuss potential uses of this technology in contributing to our understanding of the mechanisms underlying this autoimmune condition.
Detection of SARS-CoV-2 Infection in Human Nasopharyngeal Samples by Combining MALDI-TOF MS and Artificial Intelligence
Authors: Deulofeu Meritxell , García-Cuesta Esteban , Peña-Méndez Eladia María , Conde José Elías , Jiménez-Romero Orlando , Verdú Enrique , Serrando María Teresa , Salvadó Victoria , Boadas-Vaello Pere
Published: April 2021

The high infectivity of SARS-CoV-2 makes it essential to develop a rapid and accurate diagnostic test so that carriers can be isolated at an early stage. Viral RNA in nasopharyngeal samples by RT-PCR is currently considered the reference method although it is not recognized as a strong gold standard due to certain drawbacks. Here we develop a methodology combining the analysis of from human nasopharyngeal (NP) samples by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) with the use of machine learning (ML). A total of 236 NP samples collected in two different viral transport media were analyzed with minimal sample preparation and the subsequent mass spectra data was used to build different ML models with two different techniques. The best model showed high performance in terms of accuracy, sensitivity and specificity, in all cases reaching values higher than 90%. Our results suggest that the analysis of NP samples by MALDI-TOF MS and ML is a simple, safe, fast and economic diagnostic test for COVID-19.
Transduction and Adaptation Mechanisms in the Cilium or Microvilli of Photoreceptors and Olfactory Receptors From Insects to Humans
Authors: Abbas Fatima , Vinberg Frans
Published: April 2021

Sensing changes in the environment is crucial for survival. Animals from invertebrates to vertebrates use both visual and olfactory stimuli to direct survival behaviors including identification of food sources, finding mates, and predator avoidance. In primary sensory neurons there are signal transduction mechanisms that convert chemical or light signals into an electrical response through ligand binding or photoactivation of a receptor, that can be propagated to the olfactory and visual centers of the brain to create a perception of the odor and visual landscapes surrounding us. The fundamental principles of olfactory and phototransduction pathways within vertebrates are somewhat analogous. Signal transduction in both systems takes place in the ciliary sub-compartments of the sensory cells and relies upon the activation of G protein-coupled receptors (GPCRs) to close cyclic nucleotide-gated (CNG) cation channels in photoreceptors to produce a hyperpolarization of the cell, or in olfactory sensory neurons open CNG channels to produce a depolarization. However, while invertebrate phototransduction also involves GPCRs, invertebrate photoreceptors can be either ciliary and/or microvillar with hyperpolarizing and depolarizing responses to light, respectively. Moreover, olfactory transduction in invertebrates may be a mixture of metabotropic G protein and ionotropic signaling pathways. This review will highlight differences of the visual and olfactory transduction mechanisms between vertebrates and invertebrates, focusing on the implications to the gain of the transduction processes, and how they are modulated to allow detection of small changes in odor concentration and light intensity over a wide range of background stimulus levels.
Characterizing the Expression Patterns of Parkinson’s Disease Associated Genes
Authors: Li Bin , Zhao Guihu , Li Kuokuo , Wang Zheng , Fang Zhenghuan , Wang Xiaomeng , Luo Tengfei , Zhang Yi , Wang Yijing , Chen Qian , Huang Yuanfeng , Dong Lijie , Guo Jifeng , Tang Beisha , Li Jinchen
Published: April 2021

Background

The expression pattern represents a quantitative phenotype that provides an in-depth view of the molecular mechanism in Parkinson’s disease (PD); however, the expression patterns of PD-associated genes (PAGs) and their relation to age at onset (AAO) remain unclear.

Methods

The known PD-causing genes and PD-risk genes, which were collected from latest published authoritative meta-analysis, were integrated as PAGs. The expression data from Genotype-Tissue Expression database, Allen Brian Map database, and BrainSpan database, were extracted to characterize the tissue specificity, inhibitory-excitatory neuron expression profile, and spatio-temporal expression pattern of PAGs, respectively. The AAO information of PD-causing gene was download from Gene4PD and MDSgene database.

Results

We prioritized 107 PAGs and found that the PAGs were more likely to be expressed in brain-related tissues than non-brain tissues and that more PAGs had higher expression levels in excitatory neurons than inhibitory neurons. In addition, we identified two spatio-temporal expression modules of PAGs in human brain: the first module showed a higher expression level in the adult period than in the prenatal period, and the second module showed the opposite features. It showed that more PAGs belong to the first module that the second module. Furthermore, we found that the median AAO of patients with mutations in PD-causing genes of the first module was lower than that of the second module.

Conclusion

In conclusion, this study provided comprehensive landscape of expression patterns, AAO features and their relationship for the first time, improving the understanding of pathogenesis, and precision medicine in PD.
MR-Guided Radiotherapy for Liver Malignancies
Authors: Boldrini Luca , Corradini Stefanie , Gani Cihan , Henke Lauren , Hosni Ali , Romano Angela , Dawson Laura
Published: April 2021

MR guided radiotherapy represents one of the most promising recent technological innovations in the field. The possibility to better visualize therapy volumes, coupled with the innovative online adaptive radiotherapy and motion management approaches, paves the way to more efficient treatment delivery and may be translated in better clinical outcomes both in terms of response and reduced toxicity. The aim of this review is to present the existing evidence about MRgRT applications for liver malignancies, discussing the potential clinical advantages and the current pitfalls of this new technology.
Resampled Efficient Frontier Integration for MOEAs
Authors: Quintana David , Moreno David
Published: April 2021

Mean-variance portfolio optimization is subject to estimation errors for asset returns and covariances. The search for robust solutions has been traditionally tackled using resampling strategies that offer alternatives to reference sets of returns or risk aversion parameters, which are subsequently combined. The issue with the standard method of averaging the composition of the portfolios for the same risk aversion is that, under real-world conditions, the approach might result in unfeasible solutions. In case the efficient frontiers for the different scenarios are identified using multiobjective evolutionary algorithms, it is often the case that the approach to averaging the portfolio composition cannot be used, due to differences in the number of portfolios or their spacing along the Pareto front. In this study, we introduce three alternatives to solving this problem, making resampling with standard multiobjective evolutionary algorithms under real-world constraints possible. The robustness of these approaches is experimentally tested on 15 years of market data.
Development and Validation of a Data-Driven Fault Detection and Diagnosis System for Chillers Using Machine Learning Algorithms
Authors: Kim Icksung , Kim Woohyun
Published: April 2021

Fault detection and diagnosis (FDD) systems enable high cost savings and energy savings that could have economic and environmental impact. This study aims to develop and validate a data-driven FDD system for a chiller. The system uses historical operation data to capture quantitative correlations among system variables. This study evaluated the effectiveness and robustness of eight FDD classification methods based on the experimental data of the chiller (the ASHRAE 1043-RP project). The training data used for the FDD system is classified into four cases. Moreover, true and false positive rates are used to characterize the performance of the classification methods. The results show that local fault is not significantly sensitive to training data, and shows high classification accuracy for all cases. The system fault has a significant effect on the amount of data and the severity levels on the classification accuracy.
Unveiling the N-Terminal Homodimerization of BCL11B by Hybrid Solvent Replica-Exchange Simulations
Authors: Schulig Lukas , Grabarczyk Piotr , Geist Norman , Delin Martin , Forkel Hannes , Kulke Martin , Delcea Mihaela , Schmidt Christian A. , Link Andreas
Published: April 2021

Transcription factors play a crucial role in regulating biological processes such as cell growth, differentiation, organ development and cellular signaling. Within this group, proteins equipped with zinc finger motifs (ZFs) represent the largest family of sequence-specific DNA-binding transcription regulators. Numerous studies have proven the fundamental role of BCL11B for a variety of tissues and organs such as central nervous system, T cells, skin, teeth, and mammary glands. In a previous work we identified a novel atypical zinc finger domain (CCHC-ZF) which serves as a dimerization interface of BCL11B. This domain and formation of the dimer were shown to be critically important for efficient regulation of the BCL11B target genes and could therefore represent a promising target for novel drug therapies. Here, we report the structural basis for BCL11B–BCL11B interaction mediated by the N-terminal ZF domain. By combining structure prediction algorithms, enhanced sampling molecular dynamics and fluorescence resonance energy transfer (FRET) approaches, we identified amino acid residues indispensable for the formation of the single ZF domain and directly involved in forming the dimer interface. These findings not only provide deep insight into how BCL11B acquires its active structure but also represent an important step towards rational design or selection of potential inhibitors.
Estradiol-17β Regulates Expression of Luteal DNA Methyltransferases and Genes Involved in the Porcine Corpus Luteum Function In Vivo
Authors: Kaczynski Piotr , Baryla Monika , Goryszewska Ewelina , Waclawik Agnieszka
Published: April 2021

The corpus luteum (CL) is a temporary endocrine gland vital for pregnancy establishment and maintenance. Estradiol-17β (E2) is the major embryonic signal in pigs supporting the CL’s function. The mechanisms of the luteoprotective action of E2 are still unclear. The present study aimed to determine the effect of E2 on luteal expression of factors involved in CL function. An in vivo model of intrauterine E2 infusions was applied. Gilts on day 12 of pregnancy and the estrous cycle were used as referential groups. Concentrations of E2 and progesterone were elevated in CLs of gilts receiving E2 infusions, compared to placebo-treated gilts. Estradiol-17β stimulated luteal expression of DNA-methyltransferase 1 (DNMT1), but decreased expression of DNMT3B gene and protein, as well as DNMT3A protein. Similar results for DNMT3A and 3B were observed in CLs on day 12 of pregnancy compared to day 12 of the estrous cycle. Intrauterine infusions of E2 altered luteal expression of the genes involved in CL function: PTGFR, PTGES, STAR, HSD17B1, CYP19A1, and PGRMC1. Our findings indicate a role for E2 in expression regulation of factors related to CL function and a novel potential for E2 to regulate DNA methylation as putative physiological mechanisms controlling luteal gene expression.