bluuebunny/crossref_metadata_2025 huggingface dataset:
La dialecticité du concept de religion chez Hegel
Authors:   Université de Cocody-Abidjan (Côte d’Ivoire), EZOUA Cablanazann Thierry Armand
Published: February 2025

La relation de l’Homme à Dieu se dit essentiellement dans la religion qui est particulièrement digne d’intérêt, parce qu’elle est pour tous les hommes contrairement à la philosophie. Cependant, de la religion Hegel n’en donne pas une définition comme l’on a coutume de le faire dans les dictionnaires. Dans la Théorie du concept, nous trouvons la confirmation que la définition chez HEGEL s’appuie sur l’identité, au sens d’identité dialectique : « (...) cette assise fondamentale, la définition, la certitude immédiate, l’intuition intellectuelle, a été admise comme quelque chose d’immédiat, alors que, suivant sa nature, mais aussi suivant sa forme expresse, elle est quelque chose de médiatisé, parce que, essentiellement, elle ne contient pas quelque chose d’abstraitement simple, mais l’identité, en tant qu’identité de termes différents, donc la négativité et la dialectique, mais en elle-même ». HEGEL dialectise donc le concept de religion.
Urdu translation and adaptation of beliefs about psychological problems inventory (BAPPI)
Authors: Gulzar Aqsa , Ahmad Dr. Mahira
Published: February 2025

The purpose of the study was to translate and validate the Beliefs about Psychological Problems Inventory (Moraira, 2021) on a Clinical Population. Sample was comprised of 615 individuals, aged 24-40 who have been diagnosed with mild anxiety approached from outdoor psychiatric units in Lahore through convenient sampling. The results of the Confirmatory Factor Analysis (CFA) indicated a moderate-to-good fit of the model to the data, as reflected by the reported indices (GFI = .86, CFI = .90, TLI = .92, RMSEA = .08). The parameter was significant at p<.001. Hu and Bentler (1999) as well as West et al. (2012) recommend the criteria of relative indices, where χ2 /df should be in between 0 and 3, RMSEA value should be .08 or lesser and Comparative Fit Index (CFI), and Goodness of Fit Index (GFI) values of 0.9 or higher are considered as good fit whereas less than .8 is acceptable. The indices confirmed a moderate fit of the model. The translation and validation of the BAPPI ensure its relevance and applicability in addressing mental health challenges within clinical populations The current research contributes to the broader goal of promoting mental health literacy, and improving access to psychological interventions.
Fiscal policy for the digital economy: International experiences and recommendations
Authors: Nguyen Thi Hoa , Mai Thanh Huong
Published: February 2025

In the context of a rapidly developing digital economy, fiscal policy needs to be adjusted to ensure efficiency, fairness and sustainability. This article explores the fiscal policies of various countries in the context of the digital economy, focusing on tax strategies and budget allocations. The article analyzes how countries are redesigning tax systems to collect taxes from digital transactions and examines government spending on digital infrastructure and innovation, highlighting the important role The importance of strategic investments in facilitating digital transformation.
Tài chính xanh đối với suy thoái môi trường và năng lượng bền vững tại 45 quốc gia châu Á
Authors: Phạm Thị Tường Vân , Trần Thị Lệ Hiền
Published: February 2025

Nghiên cứu này chỉ ra mối quan hệ của các chỉ số kinh tế, tài chính và lượng khí thải môi trường, nhằm phân tích tác động đổi mới tài chính đến lượng thải carbon, khí thải nhà kính, và tiếp cận điện. Nghiên cứu sử dụng dữ liệu từ 45 quốc gia châu Á thu thập trong khoảng thời gian từ năm 1998 đến 2022. Kết quả nghiên cứu chỉ ra rằng POPU và GDP có tác động dương đến cả 2 biến phụ thuộc khí thải carbon CO2 và khí thải nhà kính GRHO. Đối với các biến hệ thống tài chính thì nghiên cứu chỉ ra ROE, LIRE, DOCRE, EDST có tác động tích dương đáng kể đến khí thải carbon CO2 và khí thải nhà kính GRHO. Trong khi đó COINC, ATM tác động âm đáng kể đến CO2 và GRHO. Hơn nữa, ROA, CAAS, DEPO, BORR không có tác động đáng kể đến CO2 và khí thải nhà kính GRHO. Ngoài ra, POPU, GDP, ROA, ROE, LIRE, COINC, DEPO không có tác động đáng kể đến tiếp cận điện ELEC. Đồng thời CAAS, DOCRE, BORR, ATM, EDST có tác động tích cực và đáng kể đến ELEC. Dựa trên kết quả nghiên cứu ra một số giải pháp để giảm lượng khí thải CO2 và tổng lượng khí thải nhà kính, chú trọng tập trung phân tích tác động của đổi mới tài chính hướng đến tài chính xanh và phát triển bền vững.
Rủi ro từ thị trường tài sản mã hóa đến ổn định tài chính
Authors: Nguyễn Thị Thái Hưng , Trần Thị Bích Thuận , Ngô Đức Mạnh
Published: February 2025

Kỹ thuật số ngày càng phát triển, nhiều tài sản dưới định dạng “vô hình” xuất hiện trong đó có “tài sản mã hóa”, các ứng dụng mới được tạo ra nhằm tận dụng ưu thế của loại tài sản mới này. Tuy nhiên, sau một thời gian vận hành, thị trường tài sản mã hóa đã bộc lộ các lỗ hổng, phát sinh các rủi ro ảnh hưởng đến sự ổn định của thị trường tài chính truyền thống. Thực tế này khiến nhiều quốc gia đã và đang đưa ra các biện pháp nhận biết rủi ro và quản lý các giao dịch tài sản mã hóa, nhằm vừa phát huy tối đa các ưu điểm của công nghệ, vừa kiểm soát, hạn chế được các rủi ro, nguy cơ có thể phát sinh (như lừa đảo, rửa tiền…) trong các giao dịch tài sản mã hóa trên thị trường.
Những yếu tố ảnh hưởng phát triển du lịch xanh ở tỉnh Phú Thọ và một số giải pháp
Authors: Đỗ Thị Nâng , Nguyễn Hoàng Phong , Trần Thị Thảo
Published: February 2025

Du lịch xanh được định nghĩa là các hoạt động du lịch thân thiện với môi trường và có nhiều ảnh hưởng tới sự phát triển bền vững của nền kinh tế. Dựa trên kết quả khảo sát những yếu tố ảnh hưởng đến phát triển du lịch xanh ở tỉnh Phú Thọ, bài viết gợi ý một số giải pháp thúc đẩy phát triển du lịch xanh ở tỉnh Phú Thọ trong giai đoạn tiếp theo như tiếp tục đổi mới nhận thức, tư duy về phát triển du lịch xanh cho các đối tượng nhà quản lý, doanh nghiệp, người dân và khách du lịch; hoàn thiện thế chế chính sách về phát triển du lịch xanh; phát triển nguồn nhân lực gắn với phát triển du lịch xanh; phát triển sản phẩm du lịch xanh…
Thực trạng hiệu quả hoạt động kinh doanh của các doanh nghiệp vật liệu xây dựng niêm yết ở Việt Nam và một số khuyến nghị
Authors: Nguyễn Minh Tâm
Published: February 2025

Hiệu quả hoạt động kinh doanh của một doanh nghiệp (DN) luôn được nhiều đối tượng quan tâm bởi hiệu quả hoạt động kinh doanh quyết định sự tồn tại và phát triển của doanh nghiệp. Bài viết nghiên cứu thực trạng hiệu quả kinh doanh của các doanh nghiệp vật liệu xây dựng (VLXD) niêm yết tại Việt Nam, xác đinh nguyên nhân của thực trạng, từ đó có những khuyến nghị nhằm nâng cao hiệu quả kinh doanh. Mẫu nghiên cứu gồm 30 doanh nghiệp VLXD niêm yết trong giai đoạn 2009-2023. Ngoài ra, tác giả cũng phân tích, đánh giá rủi ro kinh doanh của các DN trong mẫu nhằm làm rõ hiệu quả hoạt động kinh doanh trong tương quan với rủi ro
Desafios e Práticas da psicologia no CRAS durante a pandemia
Authors: Rubim Brandolt Catheline , Arpini Dorian Mônica , Molin Tadielo Luana
Published: February 2025

Este artigo tem por objetivo identificar os desafios e práticas das psicólogas quanto ao trabalho nos CRAS da região centro-oeste do Rio Grande do Sul durante a pandemia de Covid-19. Para isso, foram realizadas entrevistas dialógicas com dezesseis psicólogas atuantes em oito municípios, os quais foram sorteados - em plataforma online - para compor o estudo. A análise das informações foi organizada de acordo com a proposta construtivo-interpretativa. Como resultados foram identificadas profissionais que durante a pandemia se organizaram e adaptaram suas práticas frente às demandas exigidas naquele momento atípico. Destaca-se a capacidade das participantes de não terem paralisado seu trabalho, conseguindo analisar criticamente o cenário e seu fazer, alinhando suas práticas com os objetivos do SUAS e as demandas que se apresentaram. Além disso, identificou-se que as práticas coletivas ocuparam um lugar de relevância no momento de retomada das ações pós-pandemia. Por fim, observou-se nas participantes um movimento de (re)construção quanto ao saber-fazer abrangendo posicionamentos críticos-reflexivos, engajamento ético-político, bem como apropriação sobre a política pública, reconhecendo-se enquanto um agente mediador nesse campo. 
Palavras-chave: Assistência Social, Psicologia, CRAS, Pandemia.
A Percepção da equipe multiprofissional em saúde frente a pacientes não vacinados contra a COVID-19 em unidade de terapia intensiva adulto
Authors: Schroeder Tauane , Paiva Muller Karine , Calesso Moreira Mariana
Published: February 2025

O presente trabalho visa compreender a percepção dos profissionais de saúde que atuaram em Unidade de Terapia Intensiva (UTI) COVID-19 Adulto de um hospital geral do sul do Brasil em relação aos pacientes não vacinados contra a COVID-19. Trata-se de um estudo qualitativo exploratório, cujos dados foram obtidos por meio de entrevistas semiestruturadas com sete profissionais de saúde que atuaram na UTI COVID-19 Adulto de um hospital geral do sul do Brasil. As entrevistas foram analisadas a partir da análise de conteúdo de Bardin. Foram identificadas três categorias de análise, que discorreram sobre a percepção dos profissionais de saúde frente a pacientes não vacinados contra a COVID-19, os sentimentos suscitados por estes pacientes e as motivações percebidas para a não vacinação. Os pacientes em questão foram entendidos como enfermos com quadros clínicos graves e cuja situação crítica de saúde refletiu suas escolhas individuais. Tal situação suscitou nos profissionais de saúde sentimentos identificados como raiva, revolta, indignação, pena, tristeza, indiferença e impotência. Além disso, destacam-se como motivações percebidas para a não vacinação a falta de confiança e informação sobre a vacina, o medo quanto aos efeitos adversos ou inesperados dos imunizantes, questões políticas, negacionismo, argumentações conspiratórias e descrença na ciência.
Palavras-chaves: COVID-19. Recusa de Vacinação. Profissionais de saúde. Unidade de Terapia Intensiva.
Sobrecarga de mães de pessoas com deficiˆˆência
Authors: De Castro Soares de Barros Beatriz , Alves Ferreira de Rezende Aline , Maria de Castro Soares de Barros Raquel , Laura Cortellazzi Karine , De Fátima Possobom Rosana
Published: February 2025

Introdução: A maior ou menor sobrecarga percebida por cuidadores pode ser decorrente do nível de dificuldade do cuidado e do tempo dedicado à pessoa com deficiência, entre outras causas. Estudos mostram que quanto maior o nível de dependência da pessoa que recebe os cuidados,  maior a sobrecarga do cuidador. Quando se trata de crianças com deficiência, as mães são as cuidadoras majoritárias.  .  Objetivo: investigar o nível de sobrecarga das mães e conhecer seu nível de bem estar espiritual e o nível de dependência dos filhos com deficiência. Materiais e métodos: Foram entrevistadas 45 mães de crianças com deficiência, assistidos por um centro de reabilitação, que responderam questões para caracterização da amostra e os instrumentos Escala Burden Interview, Escala de bem-estar espiritual e Escala de Medida de Independência Funcional. Resultados: Pouca mais da metade das mães (55,5%) não tinha a presença do companheiro, 71,4% viviam com até 2 salários-mínimos e 62,3% não exercia trabalho remunerado. As mães tinham elevado grau de bem-estar espiritual. Em relação aos filhos, 40% apresentaram necessidade de ajuda em 50% das tarefas cotidianas. Considerações finais: O elevado grau de bem estar espiritual e a baixa percepção de sobrecarga, apesar das dificuldades que um filho com deficiência possa demandar, sugere a influencia do primeiro impactar na percepção do segundo.
Palavras-chave: Mães, sobrecarga do cuidador, crianças com deficiência, espiritualidade
Types and markers of narrative discourse in Galen's Anatomical Writings
Authors: Prolygina Irina Viktorovna
Published: February 2025

A significant part of the voluminous corpus of texts by Galen (129–210/217 AD) are composed of works written in the genre of narrative prose. In this article, using the material of his anatomical works, in particular, the work "On the bones for beginners", different types of narrative discourse and their linguistic markers are analyzed, such as first-person statements, self-references, transitions from the past tense to the present or future, metadiscursive expressions and appeals to a fictitious interlocutor, expressions of the author's opinion or value judgments, the use of extraclausal components, such as interjections and particles of the ancient Greek language. The results of the study showed that the style of narrative prose by Galen is characterized by features of conversational diaphonic discourse, which implies a continuous dialogue with the reader. Despite the author's distinct style, it is noted that Galen's prose has a number of common features with the works of the sophists of his time who belonged to the circle of the Second Sophistic, such as Lucian or Aelius Aristides, and, on the contrary, differs greatly from the technical prose of his medical contemporaries, for example, from the works of Rufus of Ephesus, Soranus or the authors of the Pseudo-Galenic corpus of texts. Further study of the narrative discourse in Galen's texts opens up broad prospects for the analysis and mapping of his texts, which will allow us to see the intertextual layers of his works that are hidden to this day, as well as to understand the specifics of Greek prose of the imperial period. The article may be useful to philologists, linguists, historians of science and medicine and find application in lecture courses and practical classes on the analytical reading of ancient authors.
Kajian Pengukuran Kepuasan Pelanggan: Konsep, Metode, dan Cara Perhitungan dalam Paradigma Expectancy Disconfirmation Theory
Authors: Heruwasto Ignatius
Published: February 2025

It is unquestionably many believe to the premise that delivering the satisfaction to the consumers would lead the benefit for the firms/industries/goverment/ and society. This concept is used as a competitive strategy for companies to create the profit. Unfortunately, beside thousands of book have been writen with the topic satisfaction, the lack of the measurement method is still prevalent today due to plenty of alternatives. This paper reviews the various meanings of the concept as well as research methods a:nd statistical calculations that can be used in the study. This paper explore each method and its correlation of each other, and also its implication. Furthermore, this study aimed to propose the conclusions about the most appropriate method to be used in customers satisfaction research, both in business and academic circles. This study reveals that there are six alternative methods of customer satisfaction research, where each method gives different results in index score. In general, the conclusion is that the method of asking directly about satisfaction is the most appropriate method to use. This study also reveals the weaknesses in each method of measurement, and explain the presence of some potential errors that often occur in the study of customer satisfaction. So, to get the research results that can be justified scientifically, researchers need to determine the appropriate method according to their research goals. This study is not only useful to enhance satisfaction research in the domain of marketing, but also can be used in the study of employee satisfaction, community satisfaction, and satisfaction of other studies outside the realm of marketing.
Anteseden dari Niat Menggunakan TikTok: Studi Kasus Pada Muslim Gen Z di Indonesia
Authors:   Fakultas Bisnis dan Ekonomika, Universitas Islam Indonesia, Viranti Dinda Nuur , Aji Hendy Mustiko ,   Fakultas Bisnis dan Ekonomika, Universitas Islam Indonesia
Published: February 2025

Penelitian ini bertujuan untuk mengetahui pengaruh persepsi kesenangan, persepsi manfaat, dan persepsi kemudahan penggunaan terhadap niat menggunakan aplikasi TikTok. Penelitian ini meng- gunakan pendekatan kuantitatif dengan metode pengumpulan data melalui kuesioner online dan di- tentukan dengan menggunakan metode non probability purposive sampling. Data didapatkan den- gan cara menyebar kuesioner secara online kepada 250 responden Muslim Generasi Z yang belum pernah menggunakan aplikasi TikTok. Hasil penelitian ini menunjukkan bahwa persepsi kemudahan penggunaan dan persepsi manfaat tidak berpengaruh terhadap niat menggunakan aplikasi TikTok, namun persepsi kesenangan konten TikTok berpengaruh positif dan signifikan terhadap persepsi manfaat, persepsi kemudahan penggunaan dan niat menggunakan aplikasi TikTok. Hasil temuan ini dapat digunakan sebagai referensi penelitian selanjutnya. Teori utama dalam penelitian ini meng- gunakan Technology Acceptance Model (TAM) yang digunakan untuk menjelaskan hubungan antara persepsi kesenangan, persepsi manfaat, persepsi kemudahan penggunaan dan niat menggunakan. Keterbatasan pada penelitian ini adalah variabel niat menggunakan aplikasi TikTok yang menun- jukkan bahwa skor R-Squarenya sebesar 0,488 atau 48,8% sehingga variabel tersebut masih belum dijelaskan dengan baik dan cukup oleh variabel antesedennya. Penelitian ini berkontribusi kepada literatur pada topik penggunaan media sosial dengan mempertimbangkan variabel persepsi kes- enangan, persepsi manfaat dan kemudahan dalam mempengaruhi niat menggunakan TikTok.
Analisis Dampak Pandemi Covid-19 kepada Tingkat dan Struktur Ketergantungan dari Imbal Hasil Saham Perusahaan Farmasi di Indonesia periode 2019-2021
Authors: Danisha Ananda Tiara , Rizkianto Eko , Prabowo Hendro
Published: February 2025

This study aims to analyze the impact of the Covid-19 Pandemic on the degree and structure of dependence on the stock return of pharmaceutical companies in Indonesia that are listed on the IDX linearly with the Jakarta Composite Index (JKSE) within the period of 2019-202. This study also wants to see whether there is an effect of increasing searches for "Covid" on the stock return of these pharmaceutical stocks. The study found that there was an effect on the degree of dependence of stock returns which was positive but there were no significant changes in the structure of dependence. Meanwhile, it is known that online searches do not have a significant impact on pharmaceutical stock returns during the pandemic.
Analisis Faktor-Faktor Yang Memengaruhi Niat Penggunaan Berkelanjutan E-Wallet
Authors:   University of Indonesia, DepokFollow, Ariel Jonathan , Iriyanti Ira ,   Departemen Manajemen, Fakultas Ekonomi dan Bisnis, Universitas Indonesia
Published: February 2025

The development of technology led to a series of disruptions that replaced conventional financial systems. The emergence of COVID-19 pandemic accelerated the adoption of digital financial services, one of which is e-wallet. With pandemic over, e-wallet companies must be able to retain their users and made sure they continue to use e-wallet for transaction. Hence, this research aims to understand the factors determining user’s intention to continue using e-wallet as their payment method. This research applies Technology Continuation Theory with the extension of Trust, Habit, Price Benefit, and Operational Constraints. This research gathered data from 251 respondents who lives on the island of Java. Data processing was conducted using the SEM-PLS Method. Research findings indicate that Habit, Attitude, and Satisfaction has a positive and significant influence on the Intention To Continue Using E-wallet, whilst Operational Constraints have a negative and significant influence. For e-wallet providers, this research provides a deeper understanding of the factors when considering continued usage of e-wallet and can potentially be used during decision making process regarding the development of e-wallet products.
Pengaruh Covid-19 Terhadap Imbal Hasil Saham Perusahaan Sektor Kesehatan, Teknologi, Keuangan, Transportasi dan Logistik yang Terdaftar di Bursa Efek Indonesia Periode Januari – Mei 2020
Authors:   Departemen Manajemen, Fakultas Ekonomi dan Bisnis, Universitas Indonesia, Salsabila Ghina , Rizkianto Eko
Published: February 2025

This study aims to explore the impact of Covid-19 confirmed cases and Covid-19 death cases on stock return of healthcare, technology, finance, transportation, and logistic sector companies listed on Indonesia Stock Exchange in January – May 2020. Using panel data regression method, the study found that Covid-19 confirmed cases significantly affect stock return of healthcare, technology, finance, transportation, and logistic sector companies. However, there are no significant impact of Covid-19 death cases on stock return of healthcare, technology, finance, transportation, and logistic sector companies.
Paulo Freire, a cultura e a educação: pensando à sombra de uma mangueira
Authors: Mazza Débora
Published: February 2025

Paulo Freire, a cultura e a educação foi redigido durante a pandemia da Covid-19. O livro traz uma tessitura teórica composta por sete textos organizados segundo uma linha histórico-cronológica da vida, do trabalho e das obras de Paulo Freire. Ousa brincar com a metáfora da mangueira que comparece em inúmeras circunstâncias na vida e nos textos de Paulo. Essa árvore lança luz e sombra, acolhida e fuga em sua “andarilhagem” pelo campo da cultura e da educação do povo nas Américas, na Europa e na África.
Cyclic Polygons in Classical Geometry, II
Authors: Guo Ren , Sönmez Nilgün
Published: February 2025

Formulas about the side lengths, diagonal lengths or radius of the circumcircle of a cyclic polygon, cyclic ideal polygon and cyclic hyperideal polygon in hyperbolic geometry can be unified.
Analysis of Evolution Characteristics of a Coastal Supercell Storm Based on Dual Radar Wind Field Inversion
Authors: Wan Fujing , Sun Min , Luo Jiangshan , Zhao Haijun
Published: February 2025

Utilizing data from ground-based encrypted automatic stations, EC reanalysis datasets, and radar observations from Qingdao and Weifang, this study conducts an intricate analysis of the morphological evolution of a supercell storm structure in the coastal region of Qingdao on June 13, 2018. The methodology employed encompasses the application of dual radar wind field inversion techniques to delineate the dynamic progression of the storm. The findings reveal that the inflow jet positioned at the rear of the supercell induces the concurrent formation of anticyclonic and cyclonic vortex pairs to the south and north flanks of the storm system, respectively. Notably, the vigorous intensification of the cyclonic vortices augments the low-level atmospheric convergence. This enhancement is conducive to the facilitation of robust upward vertical motions, thereby leading to a marked elevation in the vertical stretching term. Concurrently, the amplification of the cyclonic vorticity fortifies the rear inflow jet itself. Upon the rear inflow jet's advancement to the front side of the supercell, it engages in a dynamic interaction with the ambient easterly winds. This interaction precipitates the genesis of a nascent convective cell at the juncture characterized by the storm bow's protrusion, culminating in a transformative alteration in the supercell's morphology. In a sequential pattern, an anticyclonic storm initially exhibits a diminution in the upper atmospheric strata, subsequently extending its influence downward. The inception of the new convective cell on the front side of the supercell is notably instigated in the middle layer.
Influence of the Hardness of Insoles on the Abductor Hallucis Muscle in Baxter’s Entrapment A Cross-Over Randomized Study
Authors: Pinto-Franco Vanesa , Losa-Iglesias Marta Elena , Casado-Hernández Israel , Navarro-Flores Emmanuel , López-López Daniel , Martínez-Jiménez Eva María , Pérez-Boal Eduardo , Muñoz-Sánchez José Luis , Becerro-de-Bengoa-Vallejo Ricardo
Published: February 2025

Background: The etiology and diagnosis of heel pain are complex and multifactorial, and it has been reported that Baxter’s entrapment is responsible for up to 20% of foot disorders. The most conservative treatment of Baxter’s entrapment has been the use of custom insoles. Electromyography was considered an effective test to assess muscle activity. The aim of this study was to test the use of insoles of different hardness on muscle activity of the abductor hallucis muscle in subjects with entrapment of the lateral branch of the external plantar nerve.

Methods: 18 subjects (7 women and 11 men) diagnosed with nerve entrapment of the first branch of the lateral plantar nerve were recruited. Muscle activity of the adductor hallucis muscle was analyzed with insoles of different hardness in static and dynamic situations using electromyographic evaluation.

Results: The statistical analysis did not show statistically significant differences in the muscle activity of the abductor hallucis muscle in the static position, with and without plantar orthoses (p>0.05), in contrast, in dynamic situations statistically significant differences were found between groups (p<0.01).

Conclusions: The use of a hard insole decreases the maximum peak muscular activity of the abductor hallucis muscle in subjects with Baxter’s nerve entrapment in walking conditions.
Multi-omics analyses and machine learning prediction of oviductal responses in the presence of gametes and embryos
Authors: Finnerty Ryan M , Carulli Daniel J , Hedge Akshata , Wang Yanli , Boadu Frimpong , Winuthayanon Sarayut , Jack Cheng Jianlin , Winuthayanon Wipawee
Published: February 2025

The oviduct is the site of fertilization and preimplantation embryo development in mammals. Evidence suggests that gametes alter oviductal gene expression. To delineate the adaptive interactions between the oviduct and gamete/embryo, we performed a multi-omics characterization of oviductal tissues utilizing bulk RNA-sequencing (RNA-seq), single-cell RNA-sequencing (scRNA-seq), and proteomics collected from distal and proximal at various stages after mating in mice. We observed robust region-specific transcriptional signatures. Specifically, the presence of sperm induces genes involved in pro-inflammatory responses in the proximal region at 0.5 days post-coitus (dpc). Genes involved in inflammatory responses were produced specifically by secretory epithelial cells in the oviduct. At 1.5 and 2.5 dpc, genes involved in pyruvate and glycolysis were enriched in the proximal region, potentially providing metabolic support for developing embryos. Abundant proteins in the oviductal fluid were differentially observed between naturally fertilized and superovulated samples. RNA-seq data were used to identify transcription factors predicted to influence protein abundance in the proteomic data via a novel machine learning model based on transformers of integrating transcriptomics and proteomics data. The transformers identified influential transcription factors and correlated predictive protein expressions in alignment with the in vivo-derived data. Lastly, we found some differences between inflammatory responses in sperm-exposed mouse oviducts compared to hydrosalpinx Fallopian tubes from patients. In conclusion, our multi-omics characterization and subsequent in vivo confirmation of proteins/RNAs indicate that the oviduct is adaptive and responsive to the presence of sperm and embryos in a spatiotemporal manner.
Proteome dynamics reveal Leiomodin 1 as a key regulator of myogenic differentiation
Authors: Späth Ellen , Schüler Svenja C , Heinze Ivonne , Dau Therese , Minetti Alberto , Hofmann Maleen , von Maltzahn Julia , Ori Alessandro
Published: February 2025

During myogenic differentiation the cellular architecture and proteome of muscle stem cells and myoblasts undergo extensive remodeling. These molecular processes are only partially understood and display alterations in disease conditions as well as during aging resulting in impaired regeneration. Here, we used mass spectrometry to quantify the temporal dynamics of more than 6000 proteins during myogenic differentiation. We identified the actin nucleator leiomodin 1 (LMOD1) among a restricted subset of cytoskeletal proteins increasing in abundance in early phases of myogenic differentiation. We show that LMOD1 is already expressed by muscle stem cells
in vivo
and displays increased abundance during skeletal muscle regeneration, especially during early regeneration suggesting that LMOD1 is important for induction of myotube formation. Of note, knockdown of LMOD1 in primary myoblasts and during skeletal muscle regeneration severely affects myogenic differentiation, while overexpression accelerates and improves the formation of myotubes suggesting that LMOD1 is a critical component regulating myogenic differentiation. Mechanistically, we show that LMOD1 physically and functionally interacts with the deacetylase sirtuin1 (SIRT1), a regulator of myogenic differentiation, especially at the onset of myogenic differentiation. We demonstrate that LMOD1 influences SIRT1 localization and the expression of a subset of its target genes. Consistently, depletion or pharmacological inhibition of SIRT1 partially rescues the impairment of myogenic differentiation observed after knockdown of LMOD1. Our work identifies a new regulator of myogenic differentiation that might be targeted to improve muscle regeneration in aging and disease.
The value of initiating a pursuit in temporal decision-making
Authors: Sutlief Elissa , Walters Charlie , Marton Tanya , Hussain Shuler Marshall G
Published: February 2025

Reward-rate maximization is a prominent normative principle commonly held in behavioral ecology, neuroscience, economics, and artificial intelligence. Here, we identify and compare equations for evaluating the worth of initiating pursuits that an agent could implement to enable reward-rate maximization. We identify two fundamental temporal decision-making categories requiring the valuation of the initiation of a pursuit—forgo and choice decision-making—over which we generalize and analyze the optimal solution for how to evaluate a pursuit in order to maximize reward rate. From this reward-rate-maximizing formulation, we derive expressions for the subjective value of a pursuit, i.e. that pursuit’s equivalent immediate reward magnitude, and reveal that time’s cost is composed of an
apportionment
, in addition to, an
opportunity
cost. By re-expressing subjective value as a temporal discounting function, we show precisely how the temporal discounting function of a reward-rate-optimal agent is sensitive not just to the properties of a considered pursuit, but to the time spent and reward acquired outside of the pursuit for every instance spent within it. In doing so, we demonstrate how the apparent discounting function of a reward-rate-optimizing agent depends on the temporal structure of the environment and is a combination of hyperbolic and linear components, whose contributions relate the apportionment and opportunity cost of time, respectively. We further then show how purported signs of suboptimal behavior (hyperbolic discounting, the Delay effect, the Magnitude effect, the Sign effect) are in fact consistent with reward-rate maximization. Having clarified what features are and
are not
signs of optimal decision-making, we analyze the impact of the misestimation of reward rate-maximizing parameters in order to better account for the pattern of errors actually observed in humans and animals. We find that error in agents’ assessment of the apportionment of time that underweights the time spent outside versus inside a considered pursuit type is the likely driver of suboptimal temporal decision-making observed behaviorally. We term this the Malapportionment Hypothesis. This generalized form for reward-rate maximization and its relation to subjective value and temporal discounting allows the true pattern of errors exhibited by humans and animals to be more deeply understood, identified, and quantified, which is key to deducing the learning algorithms and representational architectures actually used by humans and animals to evaluate the worth of pursuits.
Impact of online support of physical activity management using a wearable device on renal function in patients with acute coronary syndrome: a randomized controlled trial protocol
Authors: Sato Toshimi , Suzuki Daisuke , Sasamoto Yuichiro , Ono Masahiro , Shishito Namiko , Kanazawa Kohko , Watanabe Akihito , Naito Koichi , Morishita Shinichiro , Kohzuki Masahiro
Published: February 2025

Background

Acute coronary syndromes (ACS) often cause rapid decline in renal and cardiac function. In patients with ACS, combined renal dysfunction is associated with increased overall mortality and cardiovascular events. Physical activity (PA) management may crucially contribute towards protection of renal function in patients with ACS. This article describes the study protocol of a randomized controlled trial (RCT) assessing whether online support for PA management using wearable devices and information communication technology for patients with ACS facing difficulties in participating in outpatient cardiac rehabilitation after discharge can protect renal function following disease onset.

Methods

We have designed a two-arm RCT with a 3-month follow-up period. The online support intervention incorporates monitoring of PA, pulse rate, and blood pressure using a wearable device with an accelerometer and a web application system, as well as periodic educational feedback and goal setting. The primary study endpoint is the estimated glomerular filtration rate based on serum cystatin C (eGFRcys). The intervention effect will be assessed using the eGFRcys at 3 months adjusted for baseline values. The secondary endpoints are the urine albumin/creatinine ratio, brain natriuretic peptide levels, average step count, peak oxygen uptake, quality of life, and incidence of adverse events.

Discussion

This RCT will provide evidence regarding the effectiveness of online support for PA management as a renal protection strategy following ACS onset. This novel strategy not only mitigates barriers impeding participation in outpatient cardiac rehabilitation and protects cardiac and renal function in patients with ACS, but also may contribute towards improving survival and recurrence rates, preventing dialysis, and reducing medical and long-term care costs.

Trial registration:

The trial was registered in the Japan Registry of Clinical Trials on July 5, 2024. The registration number is jRCT1022240014 (Impact of Online Support of Physical Activity Management Using a Wearable Device on Renal Function in Patients with Acute Coronary Syndrome).
Utilizing Wikipedia in Teacher Education: Student Uses and Perspectives
Authors: Wang Yu-mei , Harmer Peter A.
Published: February 2025

Since its inception, Wikipedia has become a ubiquitous source of information globally. However, its unique authorship and editing structure has been cause for controversy in regards its use as a pedagogical resource. Failure to understand its strengths and shortcomings limits its potential to assist student learning. Recognizing the place of Wikipedia in academic settings may be argued to be particularly important for students majoring in education because as future teachers, their attitudes to information resources will influence their future students. Currently, little is known about how students majoring in education use or view Wikipedia.  Therefore, this quantitative study was designed to generate a profile of Wikipedia use by education majors as well as their perceptions about its value as an educational resource. Analyses of descriptive data (means; frequencies) of 210 completed questionnaires from education majors in a large urban university in the USA indicated widespread uncertainty in the respondents about the reliability of Wikipedia which, in general, limited their use to a few low-level educational functions. Their inability or reluctance to take full advantage of Wikipedia in the classroom may be due to a pervasive indifference or active negative attitudes shown by their professors to Wikipedia as an academic resource.
Statistical Synthesis of Heckman-Based Selection with Conway-Maxwell-Poisson Probability Models
Authors: Thuo Leonard King’ora
Published: February 2025

This research elucidates the theoretical derivation and statistical foundations of the integrated HeckCOMPoisson model, which synthesizes the Heckman selection framework with the Conway-Maxwell-Poisson probability distribution. This unified statistical approach was formulated specifically to address truncated count data subject to sample selection mechanisms. The model exhibits superior statistical properties across multiple evaluation criteria: it demonstrates excellent performance in parametric Goodness-of-Fit assessments, yields consistent maximum likelihood estimates for count data with selection bias, and efficiently parameterizes both under-dispersed and over-dispersed count distributions. A distinguishing characteristic of the HeckCOMPoisson distribution is its parametric flexibility and its robust estimation properties when modeling discrete count data with heterogeneous dispersion parameters.
Soil Properties Influenced by Long-term Management Practices in the Rice-Wheat System of the Terai-Teesta Alluvial Zone, India
Authors: Pabbu Anusha , Sinha Abhas Kumar , Padbhushan Rajeev , Kumar Gopal
Published: February 2025

A factorial randomized block design was employed at Pundibari, Cooch Behar, West Bengal, India to study the long-term effects of tillage (zero tillage, ZT; conventional tillage, CT), crop residue (R) addition, and biofertilizers (B) on soil properties and wheat yield in the rice-wheat system of the Terai-Teesta Alluvial Zone. The results revealed that soil pH ranged from acidic to slightly acidic in the surface layer (0–10 cm), with the highest pH observed in ZTR1B1. Organic carbon (OC) was higher in the surface layer than in deeper layers, with the maximum OC (0.98%) recorded in ZTR1B0. However, no significant changes in OC were in deeper layers (10–40 cm). ZT treatment resulted in higher wheat yields than CT, although the combined effects of tillage and R addition did not significantly influence yield. However, significant interaction effects were between R addition and B and tillage and B on grain yield. These findings highlight the importance of soil management practices in optimizing soil health and crop productivity.
Exploration of Antioxidant and Antimicrobial Potential of Agro-industrial and Spent Waste of Camellia Sinensis
Authors: Chauhan Pooja , Sarkar Sounak , Roy Vishwaprakash , Bhatia Latika
Published: February 2025

The objective of this research was to assess the value-added potential of agro-industrial and spent black tea waste (SBTW) as a source of antimicrobial and antioxidant phenolic compounds. The influence of extraction solvent (water, ethanol, acetone and Water: ethanol = 60:40) and sample (farm waste [FW], industrial tea waste [ITW] and SBTW) and their relations on the antimicrobial and antioxidant action of the extracts were explored. Among the several extracts of FW, the acetone extract showed the highest antioxidant activity of 72.09 ± 0.35%. Aqueous extract of SBTW gave 59.30 ± 0.354% antioxidant activity. The only extract of ITW that had shown the antioxidant activity was ethanol extract with 1.16 ± 0.25% of this activity. Acetone extract of FW exhibited the highest antimicrobial activity for all investigated pathogens viz. Streptococcus sp (19.3 ± 0.35 mm), Corynebacterium sp (9.3 ± 0.25 mm) and Staphylococcus aureus (3.3 ± 0.25 mm). The antimicrobial activity of acetone extract of SBTW against Corynebacterium sp and Streptococcus sp was found significant (13.33 ± 0.35 mm). The only extracts of ITW that demonstrated antimicrobial activity were ethanol and acetone extract that showed the zone of inhibition of 8.6 ± 0.20 mm and 2.6 ± 0.10 mm for Corynebacterium sp and S. aureus respectively. Flavonoids and phenols were detected in all extracts of FW and SBTW except in the ethanol extracts of latter. Tannins were found in all the extracts of FW, ITW and SBTW except their acetone extracts. Coumarin was detected only in ethanol extracts of FW, ITW and SBTW. The important bioactive components present in the acetone extract of FW of Camellia sinensis were 4-Phenylbut-3-ene-1-yne, 1-Tridecene, Biphenyl, 1-Pentadecene, 8-Pentadecanone, 1-Nonadecene, Neophytadiene, Caffeine, 1-Nonadecene, 4-Oxazolecarboxylic acid, 4,5-dihydro-2-phenyl-, 1-methylethyl ester, Phytol, 1-Heptacosanol, Decanedioic acid, alpha Tocospirone B, Pentatriacontane, Vitamin E, Stigmasta etc. They are known antioxidants and antimicrobials and are of industrial engrossment. Moreover, phenolic compounds hold antimicrobial action against pathogenic bacteria, making them effective preservatives for prolonging the shelf life of foods and inhibiting the growth of foodborne pathogens, as well as anticancer properties, making them valuable assets in several industries, incorporating pharmaceuticals, food, and cosmetics.
Little Parcels of Joy
Authors: Ho Felicia Y.
Published: February 2025

In this narrative medicine essay, the memories of joyfully preparing meals with her parents that must shift to learning how to prepare low-glycemic foods fills a medical student’s mind when a patient during clinic learns they must stop their weekly indulgence.
COVID-19 Pandemic and Rates of Common Ophthalmic Procedures Among Medicare Beneficiaries
Authors: Mahmoudzadeh Raziyeh , Samuel Mariam , Wheeler Sydney , Salabati Mirataollah , Leffler Christopher T. , Randolph Jessica D.
Published: February 2025

Importance

The COVID-19 pandemic has altered health care delivery, including ophthalmic care. Understanding how the pandemic has changed the rates of commonly performed ophthalmic procedures is crucial for assessing the broader implications for patient care and resource allocation.

Objective

To estimate the changes in the rates of the 10 most prevalent ophthalmic procedures among Medicare beneficiaries during the COVID-19 pandemic and to explore the geographic disparities in these shifts.

Design

This retrospective US cross-sectional study compared data from Medicare Part B National Summary Data Files for the calendar years 2019 and 2020. Participants included Medicare beneficiaries undergoing the 10 most common ophthalmic procedures. Data included a total of 3 879 533 procedure entries in 2019 and 3 181 439 entries in 2020. Data were analyzed from January 1, 2019, to December 31, 2020.

Exposure

COVID-19 pandemic.

Main Outcomes and Measures

The primary outcome was the percentage change in the number of beneficiaries for each of the 10 most common ophthalmic procedures in each state.

Results

There was an overall decrease of −17.9% in the rates of the 10 ophthalmic procedures from 2019 to 2020 (99% CI, −24.8% to −11.3%). The largest reduction was observed in laser peripheral iridotomy (−43.6%; 99% CI, −51.7% to −31.9%), while eye drug injections saw the smallest decrease (−1.5%; 99% CI, −3.3% to 0.3%). Cataract surgery also saw a reduction of −23.0% (99% CI, −28.8% to −18.7%). Regionally, the Northeast experienced the greatest reductions in cataract surgery (−27.9%; 99% CI, −32.8% to −22.3%).

Conclusions and Relevance

These results show that the COVID-19 pandemic caused a notable drop in the number of common ophthalmic procedures among Medicare beneficiaries, especially in laser peripheral iridotomy, while eye drug injections saw minimal changes. The Northeast experienced the largest reductions, highlighting the pandemic’s association with changes in eye care and indicating a need for focused recovery efforts in the hardest hit areas.
Antimicrobial Peptides and Their Mimetics: Promising Candidates of Next‐Generation Therapeutic Agents Combating Multidrug‐Resistant Bacteria
Authors: Zhang Tianyi , Jin Qiao , Ji Jian
Published: February 2025

The increasing morbidity and mortality caused by multidrug‐resistant bacteria alerts human beings to the fact that conventional antibiotics are no longer reliable and effective alternatives are imperatively needed. Owing to wide range of sources, diverse structures, and unique mode of action, antimicrobial peptides have been highly anticipated and extensively studied in recent years. Besides, the integration of artificial intelligence helps researchers gain access to the vast unexplored chemical space, which opens more opportunities for the optimization and design of novel structures. Moreover, Due to advances in chemistry and synthetic biology, researchers have also begun to focus on the potential of chemical mimetics of antimicrobial peptides. In this review, a comprehensive discussion about natural and synthesized antimicrobial peptides as well as their chemical mimetics is made, so as to provide a comprehensive summary of this field and inspire follow‐up research.
Programmable DNA‐Based Nanodevices for Next‐Generation Clinical and Healthcare Applications
Authors: Kansara Krupa , Laha Anwesha , Kumar Ashutosh , Bhatia Dhiraj
Published: February 2025

Deoxyribonucleic acid (DNA) nanotechnology has brought an unparalleled set of possibilities for self‐assembled structures emerging as an independent branch of synthetic biology. The field of science uses the molecular properties of DNA to build nanoparticles and nanodevices that have the potential to bring breakthroughs in medical science. On the one hand, their biocompatibility, precision, synthetic ease, and programmability make them an ideal choice in drug delivery and healthcare. On the other, the lack of proper biodistribution profiles, stability inside the system, enzymatic cleavage, immune recognition, and translational barriers are some of the hurdles it faces. Many recent technological advancements are in progress to tackle these challenges, while some already have been used. These tools and technologies need to be understood and studied for the successful transition of these intelligent DNA nanostructures (DNs) to healthcare applications. This review thus, highlights some of the challenges being faced by the DNs in healthcare. Additionally, it provides an overview of the recent trends in using these devices in disease detection and remission and finally talks about the future scope and opportunities for an effective transition from bench to bedside.
A Sustainable Microstructure Modification‐Based Design of Al‐Si Alloys for Energy Efficient Electric Power Transmission and Distribution
Authors: Bohane Pawan , Dongare Sumedh S. , Kumar Hemant , Makineni Surendra Kumar , Gohil Trushar B. , Srivastav Ajeet K.
Published: February 2025

Power transmission and distribution systems need to be more efficient and sustainable to meet the growing electricity demand. The high conductivity of aluminum alloys is advantageous for power transmission. The present work demonstrates how the size, shape, and distribution of phases influence the electrical and thermal conductivity of a hypoeutectic Al‐Si alloy power connector. The addition of Al‐10 wt% Sr to Al‐10.5 wt% Si reduces the size of eutectic Si from 15 ± 8 μm to 0.75 ± 0.2 μm and β‐(Al‐Fe‐Si) phases from 52.85 ± 7 μm to 35.79 ± 3 μm, while slightly increasing the secondary dendrite arm spacing from 40.5 ± 3 μm to 55.2 ± 5 μm. These modifications increase the thermal conductivity from 111 to 127 W mK−1, which enhances the current density of the power connector assembly from 1.7 × 107 to 2.1 × 107 A m−2, improving its ampacity. Additionally, the Sr‐modified alloy exhibits superior corrosion resistance, with the corrosion rate decreases from 0.0416 to 0.012 mm year−1. These results are supported by finite element simulations and experimental validation, which show that microstructure optimization enhances electrical and thermal conductivity while reducing energy losses. This approach lowers the electricity demand, decreases greenhouse gas emissions, and minimizes the environmental impact of frequent replacements.