bluuebunny/crossref_metadata_2025 huggingface dataset:
Severity of Severe Acute Respiratory System Coronavirus 2 (SARS-CoV-2) Alpha Variant (B.1.1.7) in England
Authors: Grint Daniel J , Wing Kevin , Houlihan Catherine , Gibbs Hamish P , Evans Stephen J W , Williamson Elizabeth , McDonald Helen I , Bhaskaran Krishnan , Evans David , Walker Alex J , Hickman George , Nightingale Emily , Schultze Anna , Rentsch Christopher T , Bates Chris , Cockburn Jonathan , Curtis Helen J , Morton Caroline E , Bacon Sebastian , Davy Simon , Wong Angel Y S , Mehrkar Amir , Tomlinson Laurie , Douglas Ian J , Mathur Rohini , MacKenna Brian , Ingelsby Peter , Croker Richard , Parry John , Hester Frank , Harper Sam , DeVito Nicholas J , Hulme Will , Tazare John , Smeeth Liam , Goldacre Ben , Eggo Rosalind M
Published: September 2021

Background

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) alpha variant (B.1.1.7) is associated with higher transmissibility than wild-type virus, becoming the dominant variant in England by January 2021. We aimed to describe the severity of the alpha variant in terms of the pathway of disease from testing positive to hospital admission and death.

Methods

With the approval of NHS England, we linked individual-level data from primary care with SARS-CoV-2 community testing, hospital admission, and Office for National Statistics all-cause death data. We used testing data with S-gene target failure as a proxy for distinguishing alpha and wild-type cases, and stratified Cox proportional hazards regression to compare the relative severity of alpha cases with wild-type diagnosed from 16 November 2020 to 11 January 2021.

Results

Using data from 185 234 people who tested positive for SARS-CoV-2 in the community (alpha = 93 153; wild-type = 92 081), in fully adjusted analysis accounting for individual-level demographics and comorbidities as well as regional variation in infection incidence, we found alpha associated with 73% higher hazards of all-cause death (adjusted hazard ratio [aHR]: 1.73; 95% confidence interval [CI]: 1.41–2.13; P < .0001) and 62% higher hazards of hospital admission (1.62; 1.48–1.78; P < .0001) compared with wild-type virus. Among patients already admitted to the intensive care unit, the association between alpha and increased all-cause mortality was smaller and the CI included the null (aHR: 1.20; 95% CI: .74–1.95; P = .45).

Conclusions

The SARS-CoV-2 alpha variant is associated with an increased risk of both hospitalization and mortality than wild-type virus.
Systematic review and meta-analysis of the influence of prophylactic pyloric balloon dilatation in the prevention of early delayed gastric emptying after oesophagectomy
Authors: Abdelrahman Mohamed , Ariyarathenam Arun , Berrisford Richard , Humphreys Lee , Sanders Grant , Wheatley Tim , Chan David S Y
Published: September 2021

Background: Early delayed gastric emptying (DGE) occurs in up to 50% of patients following oesophagectomy, which can contribute to increased anastomotic leak and respiratory infection rates. Although the treatment of DGE in the form of pyloric balloon dilatation (PBD) post-operatively is well established, there is no consensus on the optimal approach in the prevention of DGE. The aim of this review was to determine the efficacy of prophylactic PBD in the prevention of DGE following oesophagectomy. Method: PubMed, MEDLINE and the Cochrane Library (January 1990 to April 2021) were searched for studies reporting the outcomes of prophylactic PBD in patients who underwent oesophagectomy. The primary outcome measure was the rate of DGE. Secondary outcome measures include anastomotic leak rate and length of hospital stay. Results: Three studies with a total of 203 patients [mean age 63 (26–82) years, 162 males (79.8%)] were analyzed. PBD with a 20-mm balloon was performed in 165 patients (46 patients had PBD and botox therapy) compared with 38 patients who had either no intervention or botox alone (14 patients). The pooled rates of early DGE [16.27%, 95% CI (12.29–20.24) vs. 39.02% (38.87–39.17) (P < 0.001)] and anastomotic leak [8.55%, 95% CI (8.51–8.59) vs. 12.23% (12.16–12.31), P < 0.001] were significantly lower in the PBD group. Conclusion: Prophylactic PBD with a 20-mm balloon significantly reduced the rates of early delayed gastric emptying and anastomotic leak following oesophagectomy.
The sooner the better: lives saved by the lockdown during the COVID-19 outbreak. The case of Italy
Authors: Cerqueti Roy , Coppier Raffaella , Girardi Alessandro , Ventura Marco
Published: September 2021

This paper estimates the effects of non-pharmaceutical interventions – mainly, the lockdown – on the COVID-19 mortality rate for the case of Italy, the first Western country to impose a national shelter-in-place order. We use a new estimator, the augmented synthetic control method (ASCM), that overcomes some limits of the standard synthetic control method (SCM). The results are twofold. From a methodological point of view, the ASCM outperforms the SCM in that the latter cannot select a valid donor set, assigning all the weights to only one country (Spain) while placing zero weights to all the remaining. From an empirical point of view, we find strong evidence of the effectiveness of non-pharmaceutical interventions in avoiding losses of human lives in Italy: conservative estimates indicate that the policy saved in total more than 21,000 human lives.
Bone remodelling patterns around orthodontic mini-implants migrating in bone: an experimental study in rat vertebrae
Authors: Becker Kathrin , Rauch Nicole , Brunello Giulia , Azimi Sarah , Beller Mathias , Hüfner Mira , Nienkemper Manuel , Schwarz-Herzke Beryl , Drescher Dieter
Published: September 2021

Background

Orthodontic implant migration has been clinically observed in presence of continuous loading forces. Recent studies indicate that osteocytes play a crucial role in this phenomenon.

Objectives

Aim of this study was to investigate local osteocytic gene expression, protein expression, and bone micro-structure in peri-implant regions of pressure and tension.

Material and methods

The present work reports a complementary analysis to a previous micro-computed tomography study. Two customized mini-implants were placed in one caudal rat vertebra and connected by a nickel–titanium contraction spring generating different forces (i.e. 0, 0.5, 1.0, and 1.5 N). Either at 2 or 8 weeks, the vertebrae were harvested and utilized for 1. osteocytic gene expression using laser capture micro-dissection on frozen sections coupled with qPCR, 2. haematoxylin–eosin staining for qualitative and quantitative analyses, 3. immunofluorescence staining and analysis, and 4. bone-to-implant contact on undecalcified samples.

Results

At the two time points for all the performed analyses no significant differences were observed with respect to the applied force magnitudes and cell harvesting localization. However, descriptive histological analysis revealed remarkable bone remodelling at 2 weeks of loading. At 8 weeks the implants were osseointegrated and, especially in 1.0 and 1.5 N groups, newly formed bone presented a characteristic load bearing architecture with trabecula oriented in the direction of the loading.

Conclusions

The present study confirmed that stress-induced bone remodelling is the biological mechanism of orthodontic implant migration. Bone apposition was found at ‘tension’ and ‘pressure’ sites thus limiting implant migration over time.
Comparative genome analysis of Clostridium beijerinckii strains isolated from pit mud of Chinese strong flavor baijiu ecosystem
Authors: Zou Wei , Ye Guangbin , Liu Chaojie , Zhang Kaizheng , Li Hehe , Yang Jiangang
Published: September 2021

Clostridium beijerinckii is a well-known anaerobic solventogenic bacterium which inhabits a wide range of different niches. Previously, we isolated five butyrate-producing C. beijerinckii strains from pit mud (PM) of strong-flavor baijiu (SFB) ecosystems. Genome annotation of the five strains showed that they could assimilate various carbon sources as well as ammonium to produce acetate, butyrate, lactate, hydrogen, and esters but did not produce the undesirable flavors isopropanol and acetone, making them useful for further exploration in SFB production. Our analysis of the genomes of an additional 233 C. beijerinckii strains revealed an open pangenome based on current sampling and will likely change with additional genomes. The core genome, accessory genome, and strain-specific genes comprised 1567, 8851, and 2154 genes, respectively. A total of 298 genes were found only in the five C. beijerinckii strains from PM, among which only 77 genes were assigned to Clusters of Orthologous Genes categories. In addition, 15 transposase and 12 phage integrase families were found in all five C. beijerinckii strains from PM. Between 18 and 21 genome islands were predicted for the five C. beijerinckii genomes. The existence of a large number of mobile genetic elements indicated that the genomes of the five C. beijerinckii strains evolved with the loss or insertion of DNA fragments in the PM of SFB ecosystems. This study presents a genomic framework of C. beijerinckii strains from PM that could be used for genetic diversification studies and further exploration of these strains.
Imaging the next Cascadia earthquake: optimal design for a seafloor GNSS-A network
Authors: Evans Eileen L , Minson Sarah E , Chadwell C David
Published: September 2021

The Cascadia subduction zone in the Pacific Northwest of the United States of America capable of producing magnitude ∼9 earthquakes, likely often accompanied by tsunamis. An outstanding question in this region is the degree and spatial extent of interseismic strain accumulation on the subduction megathrust. Seafloor geodetic methods combining GNSS and underwater acoustic ranging (GNSS-A) are capable of imaging this strain accumulation on the offshore portion of the subduction zone and therefore anticipating the potential size and rupture pattern of a future earthquake. However, the high cost of seafloor geodesy means that only a limited number of stations may be deployed and monitored. To facilitate expansion of current geodetic networks offshore, we develop a quantitative recommendation of optimal locations for future seafloor geodetic observations, based on the amount of new information provided by that observation. The optimal network depends on the problem that one is trying to solve with those observations (mapping subduction locking rates, coupling rates, constraining total moment rate, etc.), and on a number of modelling and data uncertainty assumptions. In particular, data uncertainty assumptions will change over time, as more position observations reduce velocity uncertainties. We find that near-trench observations on the megathrust hangingwall, distributed along-strike, consistently provide significant reduction in differential entropy over a large suite of assumptions, and that a well-placed seafloor observation can provide up to ∼30 times the information gain of the most optimal onshore observation.
Constraining the 410-km discontinuity and slab structure in the Kuril subduction zone with triplication waveforms
Authors: Li Jiaqi , Chen Min , Ning Jieyuan , Bao Tiezhao , Maguire Ross , Flanagan Megan P , Zhou Tong
Published: September 2021

The detailed structure near the 410-km discontinuity provides key constraints of the dynamic interactions between the upper mantle and the lower mantle through the mantle transition zone (MTZ) via mass and heat exchange. Meanwhile, the temperature of the subducting slab, which can be derived from its fast wave speed perturbation, is critical for understanding the mantle dynamics in subduction zones where the slab enters the MTZ. Multipathing, i.e. triplicated, body waves that bottom near the MTZ carry rich information of the 410-km discontinuity structure and can be used to constrain the discontinuity depth and radial variations of wave speeds across it. In this study, we systematically analysed the trade-off between model parameters in triplication studies using synthetic examples. Specifically, we illustrated the necessity of using array-normalized amplitude. Two 1-D depth profiles of the wave speed below the Tatar Strait of Russia in the Kuril subduction zone are obtained. We have observed triplications due to both the 410-km discontinuity and the slab upper surface. And, seismic structures for these two interfaces are simultaneously inverted. Our derived 410-km discontinuity depths for the northern and southern regions are at 420$\pm $15 and 425$\pm $15 km, respectively, with no observable uplift. The slab upper surface is inverted to be located about 50–70 km below the 410-km discontinuity. This location is between the depths of the 1 and 2 per cent P-wave speed perturbation contours of a regional 3-D full-waveform inversion (FWI) model, but we found twice the wave speed perturbation amplitude. A wave speed increase of 3.9–4.6 per cent within the slab, compared to 2.0–2.4 per cent from the 3-D FWI model, is necessary to fit the waveforms with the shortest period of 2 s, indicating that high-frequency waves are required to accurately resolve the detailed structures near the MTZ.
Challenging the liberal order: the US hegemon as a revisionist power
Authors: Chan Steve
Published: September 2021

Current discourse on International Relations conflates international order and the interstate distribution of power. Many studies fail to clarify the concept of international order or to provide systematic empirical analysis that compares states' conduct in relation to this order. The prevailing tendency relies instead on rhetorical assertion or definitional fiat to attribute revisionist and status-quo motivations to different countries. For example, power-transition theory claims that rising states are typically revisionist, whereas established states are committed to the status quo. This article presents a contrarian view, arguing that the dominant or established state can be a revisionist. This state is not forever committed to those rules and institutions of international order that it has played a decisive role in fostering. Conversely, a rising state is not inevitably bent on challenging the order that has enabled its ascendance. Revisionism is thus not unique to a rising power; moreover, this state is not destined to be a challenger to international order and an instigator of systemic war as typically depicted in the current literature. I advance these propositions in the context of recent conduct by China and the US, suggesting that whereas China has become less revisionist over time (even while its power has increased), the US has become more so especially during the Trump administration. The major impetus challenging the liberal international order has come more from domestic sources in the West than from China.
The liberal international trading order (LITO) in an era of shifting capabilities
Authors: Lobell Steven E , Ernstsen Jordan
Published: September 2021

There is much debate about the impending collapse of the liberal international order. It is provoked by the shifts in material and military capabilities from emerging peer and near-peer competitors, some of whom were not part of the original grand bargain and others that are in a stronger position to renegotiate the bargain. As one critical element of the liberal international order, we ask, during power shifts: is the liberal international trading order (LITO) durable and resilient? When and why will the LITO collapse? Does the relative decline of the hegemon alone explain these outcomes? In advancing a second-image reversed plus argument, we highlight how a shift in the nature of the foreign commercial orientation of peer and near-peer contenders can alter the domestic balance of power of two broad and logrolled coalitions competing to capture the state and thus affect whether the erstwhile leader defends, renegotiates, or abandons the trading order it created. To better understand these forces, we examine two paradigmatic cases: Britain in the 1930s and the United States in the 2000s.
Globalization, deglobalization and human security: the case of Myanmar
Authors: Hayes Jarrod , Weber Katja
Published: September 2021

Increased nationalism, greater protectionism and a gradual move away from a rules-based international order by some members of the international community do not bode well for vulnerable populations around the globe. Human security is threatened by a host of non-traditional security challenges catalysed by the growth of physical technologies and require multifaceted responses from a variety of actors. Many of those actors look to transnational networks built on globalized liberal order's social norms—what we call social technologies—for protection. The dwindling interconnectedness of deglobalization is likely to further empower corrupt governments at the expense of vulnerable citizens. This results from a decreased willingness by states and international institutions to defend human security. Whether one looks at the plight of persecuted citizens during Burma's military junta, human slaves in the fisheries off the coast of Indonesia, or farmers uprooted from their land by palm oil plantations, without social technologies to counterbalance the negative implications of physical technology the international community will lack the political capacity (sanctions, arms embargoes, travel restrictions, etc.), to aid those most in need. Ultimately, the effects of deglobalization on human security will depend largely on the trajectory of social technology developing alongside advances in physical technology.
Two emerging international orders? China and the United States
Authors: Owen John M
Published: September 2021

If it continues, deglobalization may lead not to atomization but two overlapping international orders: a liberal one (LIO) led by the United States, and an authoritarian–capitalist one (ACIO) led by China. This equilibrium could emerge because a central purpose of international orders is to preserve the domestic regimes of their Great Power sponsors. The United States and China have markedly different domestic regimes, and so as China continues to grow in power and influence, tension over the content of international order should continue to grow. I borrow from Darwinian evolution the notion of ‘niche construction’: just as organisms alter phenotype selection by manipulating their natural environments, states can alter the ‘selection’ of domestic regimes by shaping their international environments. Modes of international niche construction include foreign regime promotion, interdependence, transnational interaction and multilateral institutions. The liberal democratic niche constructed by the United States and its allies after the Second World War preserved democracy for many decades. Today, China is attempting through various means to build a niche that will eliminate the liberal bias in international institutions and safeguard its own Market-Leninist regime. The resulting ACIO would select for autocracy and hence be partially separate from the LIO, which selects for liberal democracy.
Globalization, international mobility and the liberal international order
Authors: Money Jeannette
Published: September 2021

Since the Second World War, globalization has been underpinned by a liberal international order, a rules-based system structured around the principles of economic interdependence, democracy, human rights and multilateralism. However, the relationship between international mobility and the liberal international order (LIO) is contested. In the article, I disaggregate ‘international mobility’ into three regimes: the travel regime, the voluntary (labour) migration regime, and the refugee regime—each governed by distinct norms and operating procedures. I outline the characteristics of the LIO that pertain to international mobility and provide evidence to demonstrate that none of the three dimensions of international mobility—travel, migration, and asylum—reflects these characteristics. Given the LIO principles enumerated above, the exclusion of international mobility from the LIO is surprising. I survey the scholarship on the LIO and international mobility and argue that the exclusion of international mobility from the LIO rests on benefits provided to core states by the status quo ante governing international mobility. That is, the status quo ante permits countries of destination to determine the level and type of cross-border mobility. Thus, international mobility continues to be underpinned by the play of state preferences rather than the principles of the LIO. The COVID-19 pandemic is likely to shape these norms and operating procedures in ways that reinforce the status quo.
Patients Prioritize a Low-volume Bowel Preparation in Colitis-associated Colorectal Cancer Surveillance: A Discrete Choice Experiment
Authors: Wijnands Anouk M , te Groen Maarten , Peters Yonne , Kaptein Ad A , Oldenburg Bas , Hoentjen Frank , Lutgens Maurice W M D
Published: September 2021

Background

Patients with inflammatory bowel disease (IBD) undergo surveillance colonoscopies at fixed intervals to reduce the risk of colorectal cancer (CRC). Taking patients’ preferences for determining surveillance strategies into account could improve adherence and patient satisfaction. This study aimed to determine patient preferences for CRC surveillance in IBD.

Methods

We conducted a web-based, multicenter, discrete choice experiment among adult IBD patients with an indication for surveillance. Individuals were repeatedly asked to choose between 3 hypothetical surveillance scenarios. The choice tasks were based on bowel preparation (0.3-4 L), CRC risk reduction (8% to 1%-6%), and interval (1-10 years). Attribute importance scores, trade-offs, and willingness to participate were calculated using a multinomial logit model. Latent class analysis was used to identify subgroups with similar preferences.

Results

In total, 310 of 386 sent out questionnaires were completed and included in the study. Bowel preparation was prioritized (attribute importance score 40.5%) over surveillance interval and CRC risk reduction (31.1% and 28.4%, respectively). Maximal CRC risk reduction, low-volume bowel preparation (0.3 L laxative with 2 L clear liquid) with 2-year surveillance was the most preferred combination. Three subgroups were identified: a “surveillance avoidant,” “CRC risk avoidant,” and “surveillance preferring” groups. Membership was correlated with age, educational level, perceived CRC risk, the burden of bowel preparation, and colonoscopies.

Conclusions

Inflammatory bowel disease patients consider bowel preparation as the most important element in acceptance of CRC surveillance. Heterogeneity in preferences was explained by 3 latent subgroups. These findings may help to develop an individualized endoscopic surveillance strategy in IBD patients.
On Stability of Logarithmic Tangent Sheaves: Symmetric and Generic Determinants
Authors: Faenzi Daniele , Marchesi Simone
Published: September 2021

We prove stability of logarithmic tangent sheaves of singular hypersurfaces $D$ of the projective space with constraints on the dimension and degree of the singularities of $D$. As the main application, we prove that determinants and symmetric determinants have simple (in characteristic zero, stable) logarithmic tangent sheaves and we describe an open dense piece of the associated moduli space.
Streptococcal and enterococcal endocarditis: time for individualized antibiotherapy?
Authors: Flateau Clara , Riazi Adélie , Cassard Bruno , Camus Maryse , Diamantis Sylvain
Published: September 2021

Recommendations for the treatment of streptococcal and enterococcal endocarditis are based on old efficacy studies, but the starting doses have never been reassessed and are associated with significant adverse events. Based on data from other serious infections, we suggest that maintaining a concentration of β-lactams higher than 4–6 times the responsible bacteria MIC 100% of the time in the heart of the vegetation would be a pertinent therapeutic objective. The data point to a diffusion gradient of β-lactams in the vegetation. Yet, so far as is known, the ratio of antibiotic concentration at steady state between plasma and vegetation cannot be completely determined. Answering this crucial question would make it possible for each patient to have a targeted β-lactam plasma concentration, according to the MIC for the responsible bacteria. This would lead the way to personalized antibiotherapy and allow a safe switch to oral medication.
Inulin and isomalto-oligosaccharide alleviate constipation and improve reproductive performance by modulating motility-related hormones, short-chain fatty acids, and feces microflora in pregnant sows
Authors: Yu Xiaorong , Fu Chunsheng , Cui Zhenchuan , Chen Guangyong , Xu Yinglei , Yang Caimei
Published: September 2021

Constipation in gestating and lactating sows is common and the inclusion of dietary fiber may help to alleviate this problem. We investigated the effects of inulin (INU) and isomalto-oligosaccharide (IMO), two sources of soluble dietary fiber, on gastrointestinal motility-related hormones, short-chain fatty acids (SCFA), fecal microflora, and reproductive performance in pregnant sows. On day 64 of gestation, 30 sows were randomly divided into three groups and fed as follows: a basal diet, a basal diet with 0.5% INU, and a basal diet with 0.5% IMO. We found that INU and IMO significantly modulated the levels of gastrointestinal motility-related hormones, as evidenced by an increase in substance P (P < 0.05), and a decrease in the vasoactive intestinal peptide concentrations (P < 0.05), indicating the capacity of INU and IMO to alleviate constipation. Furthermore, IMO enhanced the concentrations of acetic, propionic, isobutyric, butyric, isovaleric, and valeric acids in the feces (P < 0.05). High-throughput sequencing showed that IMO and INU increased the fecal microflora α- and β-diversity (P < 0.05). Methanobrevibacter was more abundant (P < 0.05), whereas the richness of Turicibacter was lower in the INU and IMO groups than in the control group (P < 0.05). In addition, IMO significantly increased litter size (P < 0.05). Overall, our findings indicate that INU and IMO can relieve constipation, optimize intestinal flora, and promote reproductive performance in pregnant sows.
Determining crack initiation stress in unconventional shales based on strain energy evolution
Authors: Ren Jiali , Wang Yang , Han De-Hua , Zhao Luanxiao , Long Teng , Tang Shuhang
Published: September 2021

Determining the crack initiation stress (Ci) for unconventional shale rocks is of critical importance in describing the entire failure process of unconventional shale reservoirs. We propose a new method to identify Ci values based on triaxial failure tests on four organic shale samples, attempting to improve the shortcomings of other methods. The new method is based on the relationship between crack development and strain energy evolution (SEE). Additionally, the proposed SEE method is compared with three widely used methods, including crack volumetric strain (CVS), moving point regression (MPR) and the lateral strain response (LSR), intending to examine the performance of different methods. The contrastive results indicate that the LSR method cannot determine Ci when the rock ruptures without volumetric dilatancy, which frequently occurs in the compression process of organic shales. Ci values obtained using the SEE method are consistent with those from the CVS and MPR methods. However, the proposed SEE method with a solid physical basis is more objective and stable than the CVS and MPR methods. The proposed method, from one aspect, compensates for the shortcomings of other methods when facing different failure modes in organic shales. From the other aspect, it provides a way to precisely determine Ci values for applications in wellbore stability evaluation and hydraulic fracturing design.
Development of an Attractive Toxic Sugar Bait for the Control ofAedes j. japonicus(Diptera: Culicidae)
Authors: Fryzlewicz Lauren , VanWinkle Ashlynn , Lahondère Chloé
Published: September 2021

Both female and male mosquitoes consume sugar meals to obtain carbohydrates used for energy. This behavior has recently been identified as a possible mosquito control target, as the World Health Organization has urged for the development of integrated vector management. This is critical as many medically important mosquito species are developing insecticide resistance, resulting in current control strategies becoming less effective. Additionally, the traditional use of insecticides is detrimental to many beneficial insects such as pollinators. The main goal of this study was to develop an attractive toxic sugar bait (ATSB) to limit the populations of a local invasive mosquito, Aedes j. japonicus (Theobald) (Diptera: Culicidae). An ATSB is a lure bait composed of an attractant odorant, a toxic component, and sugar that the mosquitoes can feed on. ATSBs are cost-effective, sustainable, environmentally friendly, and can be species-specific. Mosquitoes were isolated into cages or cups and each group had access to either a toxic sugar solution (containing boric acid), a control solution or a choice between the two. We tested multiple fruits, including mango, peach, blueberries, and blackberries, as well as a soda and grape juice and monitored their survival for 96 h. We found that this species fed on all tested fruit solutions and that the groups that imbibed toxic solutions died within 48 h, indicating that boric acid is an effective oral toxin against Ae. j. japonicus. Further experiments will be conducted in the field to determine the ATSBs efficacy and to monitor potential effects on off-target species.
Thematic Co-occurrence Analysis: Advancing a Theory and Qualitative Method to Illuminate Ambivalent Experiences
Authors: Scharp Kristina M
Published: September 2021

Ambivalence is a phenomenon that transcends disciplinary divides and is associated with a myriad of mixed outcomes. Yet, identifying and representing the complexities of ambivalent experiences can be difficult using traditional qualitative methods. Thus, the goal of the present study was to advance a qualitative method, thematic co-occurrence analysis, to address this issue. To illustrate the usefulness of this method, I present a case study detailing 35 estranged adult children’s ambivalent responses and reactions to their parents’ (non)contact during the COVID-19 pandemic. Findings reveal seven themes and four (non)relationships between them that reflect (a) theme independence, (b) unilateral co-occurrence, (c) unbalanced co-occurrence, and (d) complementary co-occurrence. These findings advance a theory of ambivalence and corresponding method to aid in the future investigations of ambivalent phenomena.
The Science of Open (Communication) Science: Toward an Evidence-Driven Understanding of Quality Criteria in Communication Research
Authors: Freiling Isabelle , Krause Nicole M , Scheufele Dietram A , Chen Kaiping
Published: September 2021

Paralleling very visible debates in psychology, some parts of the communication field have recently pushed for a wholesale endorsement of the principles of open science and its practices, including a particular focus on replicability and reproducibility as quality criteria. Unfortunately, these discussions have been plagued by a set of at least 3 interrelated problems: A lack of conceptual clarity when defining open science-related challenges to communication scholarship; the irony of using intuition rather than evidence when trying to improve communication science; and our field’s surprising lack of attention to nonreplicability in social media data as one of our field’s most rapidly growing data sources. In response to these problem areas, we argue that communication as a field proceed empirically as it applies open science practices to different subfields in communication and end our essay with pathways forward for a science of open (communication) science.
Heterosis goes underground
Authors: Monforte Antonio J
Published: September 2021

This article comments on:

Dafna A, Halperin I, Oren E, Isaacson T, Tzuri G, Meir A, Schaffer AA, Burger J, Tadmor Y, Buckler ES, Gur A. 2021. Underground heterosis for yield improvement in melon. Journal of Experimental Botany 72, 6205–6218.
Plasticity of root anatomy during domestication of a maize-teosinte derived population
Authors: Chen Zhe , Sun Junli , Li Dongdong , Li Pengcheng , He Kunhui , Ali Farhan , Mi Guohua , Chen Fanjun , Yuan Lixing , Pan Qingchun
Published: September 2021

Maize (Zea mays L.) has undergone profound changes in root anatomy for environmental adaptation during domestication. However, the genetic mechanism of plasticity of maize root anatomy during the domestication process remains unclear. In this study, high-resolution mapping was performed for nine root anatomical traits using a maize-teosinte population (mexicana × Mo17) across three environments. Large genetic variations were detected for different root anatomical traits. The cortex, stele, aerenchyma areas, xylem vessel number, and cortical cell number had large variations across three environments, indicating high plasticity. Sixteen quantitative trait loci (QTL) were identified, including seven QTL with QTL × environment interaction (EIQTL) for high plasticity traits and nine QTL without QTL × environment interaction (SQTL). Most of the root loci were consistent with shoot QTL depicting domestication signals. Combining transcriptome and genome-wide association studies revealed that AUXIN EFFLUX CARRIER PIN–FORMED LIKE 4 (ZmPILS4) serves as a candidate gene underlying a major QTL of xylem traits. The near-isogenic lines (NILs) with lower expression of ZmPILS4 had 18–24% more auxin concentration in the root tips and 8–15% more xylem vessels. Nucleotide diversity values analysis in the promoter region suggested that ZmPILS4 was involved in maize domestication and adaptation. These results revealed the potential genetic basis of root anatomical plasticity during domestication.
BnaC7.ROT3, the causal gene of cqSL-C7, mediates silique length by affecting cell elongation in Brassica napus
Authors: Zhou Xianming , Zhang Haiyan , Wang Pengfei , Liu Ying , Zhang Xiaohui , Song Yixian , Wang Zhaoyang , Ali Ahmad , Wan Lili , Yang Guangsheng , Hong Dengfeng
Published: September 2021

Siliques are a major carbohydrate source of energy for later seed development in rapeseed (Brassica napus). Thus, silique length has received great attention from breeders. We previously detected a novel quantitative trait locus cqSL-C7 that controls silique length in B. napus. Here, we further validated the cqSL-C7 locus and isolated its causal gene (BnaC7.ROT3) by map-based cloning. In ‘Zhongshuang11’ (parent line with long siliques), BnaC7.ROT3 encodes the potential cytochrome P450 monooxygenase CYP90C1, whereas in ‘G120’ (parent line with short siliques), a single nucleotide deletion in the fifth exon of BnaC7.ROT3 results in a loss-of-function truncated protein. Sub-cellular localization and expression pattern analysis revealed that BnaC7.ROT3 is a membrane-localized protein mainly expressed in leaves, flowers and siliques. Cytological observations showed that the cells in silique walls of BnaC7.ROT3-transformed positive plants were longer than those of transgene-negative plants in the background of ‘G120’, suggesting that BnaC7.ROT3 affects cell elongation. Haplotype analysis demonstrated that most alleles of BnaC7.ROT3 are favorable in B. napus germplasms, and its homologs may also be involved in silique length regulation. Our findings provide novel insights into the regulatory mechanisms of natural silique length variations and valuable genetic resources for the improvement of silique length in rapeseed.
MdUGT88F1-mediated phloridzin biosynthesis coordinates carbon and nitrogen accumulation in apple
Authors: Zhou Kun , Hu Lingyu , Yue Hong , Zhang Zhijun , Zhang Jingyun , Gong Xiaoqing , Ma Fengwang
Published: September 2021

The high accumulation of phloridzin makes apple (Malus domestica) unique in the plant kingdom, which suggests a vital role of its biosynthesis in physiological processes. In our previous study, silencing MdUGT88F1 (a key UDP-GLUCOSE: PHLORETIN 2’-O-GLUCOSYLTRANSFERASE gene) revealed the importance of phloridzin biosynthesis in apple development and Valsa canker resistance. Here, results from MdUGT88F1-silenced lines showed that phloridzin biosynthesis was indispensable for normal chloroplast development and photosynthetic carbon fixation by maintaining MdGLK1/2 (GOLDEN2-like1/2) expression. Interestingly, increased phloridzin biosynthesis did not affect plant (or chloroplast) development, but reduced nitrogen accumulation, leading to chlorophyll deficiency, light sensitivity, and sugar accumulation in MdUGT88F1-overexpressing apple lines. Further analysis revealed that MdUGT88F1-mediated phloridzin biosynthesis negatively regulated the cytosolic glutamine synthetase1-asparagine synthetase-asparaginase (GS1-AS-ASPG) pathway of ammonium assimilation and limited chlorophyll synthesis in apple shoots. The interference of phloridzin biosynthesis in the GS1-AS-ASPG pathway was also assumed to be associated with its limitation of the carbon skeleton of ammonium assimilation through metabolic competition with the tricarboxylic acid cycle. Taken together, our findings shed light on the role of MdUGT88F1-mediated phloridzin biosynthesis in the coordination between carbon and nitrogen accumulation in apple trees.
Overuse Injury in Military Working Dog Handlers: A Pattern of Behavior and a Path to Prevention
Authors: Patt Michael W , Oh Jeremiah T , Branstetter Joanna G , Benavides Jerome M
Published: September 2021

Military working dog handlers and their canine partners continue to be invaluable team members on missions of national importance, but little information exists in the medical literature regarding specific musculoskeletal injuries to military working dog handlers. We report a case of a dog handler with overuse shoulder traction injuries due to leash lunges from their dog in an effort to provide diagnostic insight and treatment options and look at prevention of common musculoskeletal manifestations of overuse in working dog handlers.
Understanding matched filters for precision cosmology
Authors: Zubeldia Íñigo , Rotti Aditya , Chluba Jens , Battye Richard
Published: September 2021

Matched filters are routinely used in cosmology in order to detect galaxy clusters from mm observations through their thermal Sunyaev–Zeldovich (tSZ) signature. In addition, they naturally provide an observable, the detection signal-to-noise or significance, which can be used as a mass proxy in number counts analyses of tSZ-selected cluster samples. In this work, we show that this observable is, in general, non-Gaussian, and that it suffers from a positive bias, which we refer to as optimization bias. Both aspects arise from the fact that the signal-to-noise is constructed through an optimization operation on noisy data, and hold even if the cluster signal is modelled perfectly well, no foregrounds are present, and the noise is Gaussian. After reviewing the general mathematical formalism underlying matched filters, we study the statistics of the signal-to-noise with a set Monte Carlo mock observations, finding it to be well-described by a unit-variance Gaussian for signal-to-noise values of 6 and above, and quantify the magnitude of the optimization bias, for which we give an approximate expression that may be used in practice. We also consider the impact of the bias on the cluster number counts of Planck and the Simons Observatory (SO), finding it to be negligible for the former and potentially significant for the latter.
Atomic data and the density structures of planetary nebulae
Authors: Juan de Dios Leticia , Rodríguez Mónica
Published: September 2021

We study the density structures of planetary nebulae implied by four diagnostics that sample different regions within the nebulae: [S ii] λ6716/λ6731, [O ii] λ3726/λ3729, [Cl iii] λ5518/λ5538, and [Ar iv] λ4711/λ4740. We use a sample of 46 objects with deep spectra that allow the calculation of the electron density from these four diagnostics, and explore the impact that different atomic data have on the results. We compare the observational results with those obtained from photoionization models characterized by three different density structures. We conclude that the atomic data used in the calculations of electron density fully determine the density structures that are derived for the objects. We illustrate this by selecting three combinations of atomic data that lead to observational results that are compatible with each of the three different density structures explored with the models.
Determining the full satellite population of a Milky Way-mass halo in a highly resolved cosmological hydrodynamic simulation
Authors: Grand Robert J J , Marinacci Federico , Pakmor Rüdiger , Simpson Christine M , Kelly Ashley J , Gómez Facundo A , Jenkins Adrian , Springel Volker , Frenk Carlos S , White Simon D M
Published: September 2021

We investigate the formation of the satellite galaxy population of a Milky Way-mass halo in a very highly resolved magnetohydrodynamic cosmological zoom-in simulation (baryonic mass resolution mb = 800 $\rm M_{\odot }$). We show that the properties of the central star-forming galaxy, such as the radial stellar surface density profile and star formation history, are (i) robust to stochastic variations associated with the so-called Butterfly Effect and (ii) well converged over 3.5 orders of magnitude in mass resolution. We find that there are approximately five times as many satellite galaxies at this high resolution compared to a standard ($m_b\sim 10^{4-5}\, \rm M_{\odot }$) resolution simulation of the same system. This is primarily because two-thirds of the high-resolution satellites do not form at standard resolution. A smaller fraction (one-sixth) of the satellites present at high-resolution form and disrupt at standard resolution; these objects are preferentially low-mass satellites on intermediate- to low-eccentricity orbits with impact parameters ≲30 kpc. As a result, the radial distribution of satellites becomes substantially more centrally concentrated at higher resolution, in better agreement with recent observations of satellites around Milky Way-mass haloes. Finally, we show that our galaxy formation model successfully forms ultra-faint galaxies and reproduces the stellar velocity dispersion, half-light radii, and V-band luminosities of observed Milky Way and Local Group dwarf galaxies across six orders of magnitude in luminosity (103–$10^{9}\, \rm L_{\odot }$).
Statistical tests of young radio pulsars with/without supernova remnants: implying two origins of neutron stars
Authors: Cui Xiang-Han , Zhang Cheng-Min , Li Di , Zhang Jian-Wei , Peng Bo , Zhu Wei-Wei , Wu Qing-Dong , Wang Shuang-Qiang , Wang Na , Wang De-Hua , Yang Yi-Yan , Diao Zhen-Qi , Ye Chang-Qing , Chang Hsiang-Kuang
Published: September 2021

The properties of the young pulsars and their relations to the supernova remnants (SNRs) have been the interesting topics. At present, 383 SNRs in the Milky Way Galaxy have been published, which are associated with 64 radio pulsars and 46 pulsars with high-energy emissions. However, we noticed that 630 young radio pulsars with the spin periods of less than half a second have been not yet observed the SNRs surrounding or nearby them, which arises a question of that could the two types of young radio pulsars with/without SNRs hold the distinctive characteristics? Here, we employ the statistical tests on the two groups of young radio pulsars with (52) and without (630) SNRs to reveal if they share the different origins. Kolmogorov–Smirnov (K–S) and Mann–Whitney–Wilcoxon (M–W–W) tests indicate that the two samples have the different distributions with parameters of spin period (P), derivative of spin period ($\dot{P}$), surface magnetic field strength (B), and energy loss rate ($\dot{E}$). Meanwhile, the cumulative number ratio between the pulsars with and without SNRs at the different spin-down ages decreases significantly after $\rm 10\!-\!20\, kyr$. So we propose that the existence of the two types of supernovae (SNe), corresponding to their SNR lifetimes, which can be roughly ascribed to the low- and high-energy SNe. Furthermore, the low-energy SNe may be formed from the $\rm 8\!-\!12\, M_{\odot }$ progenitor, e.g. possibly experiencing the electron capture, while the main-sequence stars of $\rm 12\!-\!25\, M_{\odot }$ may produce the high-energy SNe probably by the iron core collapse.
Asteroseismology of low-mass stars: the balance between partial ionization and Coulomb interactions
Authors: Brito Ana , Lopes Ilídio
Published: September 2021

All cool stars with outer convective zones have the potential to exhibit stochastically excited stellar oscillations. In this work, we explore the outer layers of stars less massive than the Sun. In particular, we have computed a set of stellar models ranging from 0.4 to 0.9 M⊙ with the aim at determining the impact on stellar oscillations of two physical processes occurring in the envelopes of these stars. Namely, the partial ionization of chemical elements and the electrostatic interactions between particles in the outer layers. We find that alongside with partial ionization, Coulomb effects also impact the acoustic oscillation spectrum. We confirm the well-known result that as the mass of a star decreases, the electrostatic interactions between particles become relevant. We found that their impact on stellar oscillations increases with decreasing mass, and for the stars with the lowest masses (M ≲ 0.6 M⊙), it is shown that Coulomb effects dominate over partial ionization processes producing a strong scatter on the acoustic modes. The influence of Coulomb interactions on the sound-speed gradient profile produces a strong oscillatory behaviour with diagnostic potential for the future.
Lyman-alpha opacities at z = 4–6 require low mass, radiatively-suppressed galaxies to drive cosmic reionization
Authors: Ocvirk Pierre , Lewis Joseph S W , Gillet Nicolas , Chardin Jonathan , Aubert Dominique , Deparis Nicolas , Thélie Émilie
Published: September 2021

The high redshift Lyman-α forest, in particular the Gunn-Peterson trough, is the most unambiguous signature of the neutral to ionized transition of the intergalactic medium (IGM) taking place during the Epoch of Reionization. Recent studies have shown that reproducing the observed Lyman-α opacity distributions after overlap required a non-monotonous evolution of cosmic emissivity: rising, peaking at z ∼ 6, and then decreasing onwards to z = 4. Such an evolution is puzzling considering galaxy buildup and the cosmic star formation rate are still continously on the rise at these epochs. Here, we use new RAMSES-CUDATON simulations to show that such a peaked evolution may occur naturally in a fully coupled radiation-hydrodynamical framework. In our fiducial run, cosmic emissivity at z > 6 is dominated by a low mass (${\rm M_{DM}}\lt 2 \times 10^9 \rm \,M_{\odot }$), high escape fraction halo population, driving reionization, up to overlap. Approaching z = 6, this population is radiatively suppressed due to the rising ionizing UV background, and its emissivity drops. In the meantime, the high mass halo population builds up and its emissivity rises, but not fast enough to compensate the dimming of the low mass haloes, because of low escape fractions. The combined ionizing emissivity of these two populations therefore naturally results in a rise and fall of the cosmic emissivity, from z = 12 to z = 4, with a peak at z ∼ 6. An alternative run, which features higher escape fractions for the high mass haloes and later suppression at low mass, leads to overshooting the ionizing rate, over-ionizing the IGM and therefore too low Lyman-α opacities.