bluuebunny/crossref_metadata_2025 huggingface dataset:
Parental support of the Canadian 24-hour movement guidelines for children and youth: prevalence and correlates
Authors: Rhodes Ryan E. , Spence John C. , Berry Tanya , Faulkner Guy , Latimer-Cheung Amy E. , O’Reilly Norman , Tremblay Mark S. , Vanderloo Leigh
Published: October 2019

Background

To explore the prevalence of parental support for meeting the Canadian 24-Hour Movement Guidelines for Children and Youth, identify key interactive support profiles among the four movement behaviors, and investigate subsequent sociodemographic and social cognitive correlates of these profiles.

Methods

A sample of Canadian parents (N = 1208) with children aged 5 to 17 years completed measures of the theory of planned behavior (TPB), and support of the four child movement behaviors via questionnaire. Differences in the proportion of parents supporting these four health behaviors were explored and demographic and social cognitive (attitude and perceived control) correlates of combinations of parental support for the four health behaviors were evaluated.

Results

Child and youth sleep behavior had the highest parental support (73%) and moderate to vigorous physical activity support had the lowest prevalence (23%). Interactive profiles of the four movement behaviors yielded six primary clusters and comprised wide variation from parents who supported none of these behaviors (19%), to parents who supported all four behaviors (14%). These profiles could be distinguished by the age of the child (younger children had higher support) and the gender of the parent (mothers provided more support), as well as constructs of the TPB, but TPB cognitions were more specific predictors of each health behavior rather than general predictors of aggregate health behavior clusters.

Conclusions

Teenagers and fathers may represent key targets for parental support intervention of the 24-Hour Movement Guidelines. Intervention content may need to comprise the underlying foundations of attitude and perceived behavioral control to change parental support while considering the unique features of each health behavior to maximize related intervention effectiveness.
Reliability of a new measure to assess modern screen time in adults
Authors: Vizcaino Maricarmen , Buman Matthew , DesRoches C. Tyler , Wharton Christopher
Published: October 2019

Background

Screen time among adults represents a continuing and growing problem in relation to health behaviors and health outcomes. However, no instrument currently exists in the literature that quantifies the use of modern screen-based devices. The primary purpose of this study was to develop and assess the reliability of a new screen time questionnaire, an instrument designed to quantify use of multiple popular screen-based devices among the US population.

Methods

An 18-item screen-time questionnaire was created to quantify use of commonly used screen devices (e.g. television, smartphone, tablet) across different time points during the week (e.g. weekday, weeknight, weekend). Test-retest reliability was assessed through intra-class correlation coefficients (ICCs) and standard error of measurement (SEM). The questionnaire was delivered online using Qualtrics and administered through Amazon Mechanical Turk (MTurk).

Results

Eighty MTurk workers completed full study participation and were included in the final analyses. All items in the screen time questionnaire showed fair to excellent relative reliability (ICCs = 0.50–0.90; all < 0.000), except for the item inquiring about the use of smartphone during an average weekend day (ICC = 0.16,p = 0.069). The SEM values were large for all screen types across the different periods under study.

Conclusions

Results from this study suggest this self-administered questionnaire may be used to successfully classify individuals into different categories of screen time use (e.g. high vs. low); however, it is likely that objective measures are needed to increase precision of screen time assessment.
Trajectories of Haemoglobin and incident stroke risk: a longitudinal cohort study
Authors: Dayimu Alimu , Qian Wendi , Fan Bingbing , Wang Chunxia , Li Jiangbing , Wang Shukang , Ji Xiaokang , Zhou Guangshuai , Zhang Tao , Xue Fuzhong
Published: October 2019

Background

Studies have demonstrated that high or low haemoglobin increases the risk of stroke. Previous studies, however, performed only a limited number of haemoglobin measurements, while there are dynamic haemoglobin changes over the course of a lifetime. This longitudinal cohort study aimed to classify the long-term trajectory of haemoglobin and examine its association with stroke incidence.

Methods

The cohort consisted of 11,431 participants (6549 men) aged 20 to 50 years whose haemoglobin was repeatedly measured 3–9 times during 2004–2015. A latent class growth mixture model (LCGMM) was used to classify the long-term trajectory of haemoglobin concentrations, and hazard ratios (HRs) and 95% confidence intervals (95% CI) according to the Cox proportional hazard model were used to investigate the association of haemoglobin trajectory types with the risk of stroke.

Results

Three distinct trajectory types, high-stable (n = 5395), normal-stable (n = 5310), and decreasing (n = 726), were identified, with stroke incidence rates of 2.7, 1.9 and 3.2 per 1000 person-years, respectively. Compared to the normal-stable group, after adjusting for the baseline covariates, the decreasing group had a 2.94-fold (95% CI 1.22 to 7.06) increased risk of developing stroke. Strong evidence was observed in men, with an HR (95% CI) of 4.12 (1.50, 11.28), but not in women (HR = 1.66, 95% CI 0.34, 8.19). Individuals in the high-stable group had increased values of baseline covariates, but the adjusted HR (95% CI), at 1.23 (0.77, 1.97), was not significant for the study cohort or for men and women separately.

Conclusions

This study revealed that a decreasing haemoglobin trajectory was associated with an increased risk of stroke in men. These findings suggest that long-term decreasing haemoglobin levels might increase the risk of stroke.
Knowledge, attitudes, practices and information demand in relation to haze in China: a cross-sectional study
Authors: Zhao Minghui , Zhang Meiling , Ying Jie , Wang Shouqi , Shi Ying , Li Huanhuan , Li Yuan , Xing Zhuangjie , Sun Jiao
Published: October 2019

Background

Information on the effects of haze on health and corresponding knowledge, attitudes, and practices (KAP) will improve self-care ability against the ill effects of haze pollution and make environmental health policies more targeted and effective. In this study, we aim to determine the KAP and information demand in the context of haze and its effects on health.

Methods

A cross-sectional survey was conducted in Changchun, China, between October and November 2016. A purposive sample comprising four groups (college students, occupational population, traffic police, and elderly population) were investigated. Personal information and questions pertaining to KAP and information demand on haze pollution and health were collected through questionnaire.

Results

The questionnaire was completed by 888 residents. The awareness rate was 57.7% and varied significantly with education, exercise, and population group (p < 0.05). Among the four groups, college students scored the lowest in attitudes and practices, whereas traffic police scored the highest. Concerning the source of information demand, the elderly and traffic police preferred traditional information access (i.e., television and newspaper), whereas college students and the occupational population preferred new social media (i.e., mobile newspaper and social media sites). Regarding the most trusted department that releases information, all residents relied on the haze information released by the environmental protection department and meteorological department. The latest air quality was the most desired information of the residents.

Conclusions

Changchun residents have a relatively high knowledge awareness rate. The elderly and less-educated residents are the targetable population for haze education. Education should be disseminated in such manner as to meet the needs of different people.
CoQ10 ameliorates monosodium glutamate-induced alteration in detrusor activity and responsiveness in rats via anti-inflammatory, anti-oxidant and channel inhibiting mechanisms
Authors: El Agamy Dalia F. , Naguib Yahya M.
Published: October 2019

Background

Competent detrusor muscles with coordinated contraction and relaxation are crucial for normal urinary bladder storage and emptying functions. Hence, detrusor instability, and subsequently bladder overactivity, may lead to undesirable outcomes including incontinence. Multiple mechanisms may underlie the pathogenesis of detrusor overactivity including inflammation and oxidative stress. Herein, we tested the possibility that CoQ10 may have a potential therapeutic role in detrusor overactivity.

Methods

Forty adult male Wistar albino rats weighing 100-150 g were used in the present study. Rats were divided (10/group) into control (receiving vehicles), monosodium glutamate (MSG)-treated (receiving 5 mg/kg MSG daily for 15 consecutive days), MSG + OO-treated (receiving concomitantly 5 mg/kg MSG and olive oil for 15 consecutive days), MSG + CoQ10-treated (receiving concomitantly 5 mg/kg MSG and 100 mg/kg CoQ10 daily for 15 consecutive days) groups.

Results

MSG resulted in significant increase in bladder weight and sensitised the bladder smooth muscles to acetylcholine. MSG has also resulted in significant increase in bladder TNF-α, IL-6, malondialdehyde, nerve growth factor and connexion 43, with significant decrease in the antioxidant enzymes superoxide dismutase and catalase. Olive oil had no effect on MSG induced alterations of different parameters. Treatment with CoQ10 has resulted in a significant restoration of all the altered parameters.

Conclusion

Taken together, our results suggest that CoQ10 antagonizes the deleterious effects of MSG on detrusor activity. We propose that CoQ10 could be a therapeutic strategy targeting urinary bladder dysfunction.
Hypoparathyroidism, Sensorineural deafness and renal disease (Barakat syndrome) caused by a reduced gene dosage in GATA3: a case report and review of literature
Authors: Joseph Anne D. D. , Sirisena Nirmala D. , Kumanan Thirunavukarasu , Sujanitha Vathualan , Strelow Veronika , Yamamoto Raina , Wieczorek Stefan , Dissanayake Vajira H. W.
Published: October 2019

Background

Barakat syndrome is an autosomal dominant rare genetic disease caused by haploinsufficiency of the GATA binding protein 3 (GATA3) gene. It is also known as HDR syndrome, and is characterized by varying degrees of hypoparathyroidism, sensorineural deafness and renal disease. This is the first report of a heterozygous GATA3 whole gene deletion causing HDR syndrome in a Sri Lankan family.

Case presentation

A 13-year-old boy with an acute febrile illness, hypocalcaemia and bilateral carpopedal spasm was referred for evaluation. A past medical history of treatment for persistent hypocalcaemic symptoms since the age of 7 months was obtained. Biochemical investigations showed persistent low serum corrected calcium levels with hyperphosphataemia, hypomagnesaemia, low parathyroid hormone levels, hypercalciuria, and low total 25-hydroxy vitamin D levels. His renal functions and renal sonography were normal. Audiometry showed bilateral moderate to severe sensorineural hearing loss. On screening, his mother was also found to have asymptomatic hypocalcaemia, hypomagnesaemia, hyperphosphataemia, hypercalciuria and low total 25-hydroxy vitamin D levels. She had impaired renal functions and chronic parenchymal changes in the renal scan. Audiometry showed bilateral profound sensorineural hearing loss. Genetic analysis using multiplex-ligation dependent probe amplification showed a reduced gene dosage for GATA3 that is consistent with a heterozygous whole gene deletion in both the child and mother.

Conclusions

This report demonstrates the wide intra-familial phenotypic variability observed in HDR syndrome and adds further to the existing scientific literature on the genotype-phenotype correlation of this syndrome. It highlights the need for HDR syndrome to be considered in the differential diagnosis of persistent hypocalcaemia with sensorineural deafness and/or renal involvement, and for appropriate genetic evaluation to be done to confirm the diagnosis.
Phytochemical composition of wormwood (Artemisia gmelinii) extracts in respect of their antimicrobial activity
Authors: Mamatova Aliya S. , Korona-Glowniak Izabela , Skalicka-Woźniak Krystyna , Józefczyk Aleksandra , Wojtanowski Krzysztof K. , Baj Tomasz , Sakipova Zuriyadda B. , Malm Anna
Published: October 2019

Background

Extracts from medicinal plants with phytochemicals with known antimicrobial properties can be an effective adjunct in the complex treatment of infectious diseases. This study aimed to evaluate the antimicrobial activity of wormwood extracts collected in Kazakhstan (Artemisia gmelinii Weber ex Stechm.), along with their phytochemical analysis.

Methods

The ethanolic and chloroform extracts were subjected to HPLC combined with quadrupole time-of-flight mass spectrometry method. For quantitative assessment of antimicrobial activity, minimal inhibitory concentration (MIC) of the tested extracts was determined by micro-dilution broth method for the panel of the reference microorganisms. Minimal bactericidal concentration (MBC) or minimal fungicidal concentration (MFC) were also determined.

Results

LC/MS analysis showed the presence of 13 compounds in the tested extracts, including flavonoids: apigenin, luteolin, rutin, two O-methylated flavonols (isorhamnetin, rhamnazine), coumarin compounds (umbelliferone, scopoletin and scopolin (scopoletin 7-glucoside), 3-hydroxycoumarin and 4-hydroxycoumarin), chlorogenic acid and two dicaffeoylquinic acid isomers. Quantitative HPLC analysis showed that umbelliferone was dominant in the chloroform extract while chlorogenic acid was identified as a main compound in the ethanolic extract. The antibacterial and antifungal activity of chloroform and ethanolic extracts was comparable. The most sensitive were the Gram-positive bacteria represented by staphylococci, Micrococcus luteus and Bacillus spp. (MIC = 1.25–5 mg/ml) and yeasts represented by Candida spp. (MIC = 2.5–5 mg/ml), irrespective of the assayed extract.

Conclusions

Extracts of wormwood Artemisia gmelinii have shown a wide spectrum of antibacterial and antifungal activity. Luteolin, rutin, isorhamnetin and scopolin were identified in A. gmelinii species for the first time. The determining of the most potential compounds of Artemisia gmelinii can be used to develop effective antibacterial and antifungal agents.
Association between medical student debt and choice of specialty: a 6-year retrospective study
Authors: Fritz Erik M. , van den Hoogenhof Suzanne , Braman Jonathan P.
Published: October 2019

Background

The effect of rapidly increasing student debt on medical students’ ultimate career plans is of particular interest to residency programs desiring to enhance recruitment, including primary care specialties. Previous survey studies of medical students indicate that amount of student debt influences choice of medical specialty. Research on this topic to date remains unclear, and few studies have included the average income of different specialties in analyses. The purpose of this study is to observe whether empirical data demonstrates an association between debt of graduating medical students and specialties into which students match.

Methods

This was a retrospective cross-sectional study of a public institution including data from graduation years 2010–2015. For each included student, total educational debt at graduation and matched specialty were obtained. Average income of each specialty was also obtained. Statistical hypothesis testing was performed to analyze any differences in average debt among specialties; subanalysis was performed assessing debt for primary care (PC) versus non-primary care (NPC) specialties. Correlation between student debt and average specialty income was also evaluated.

Results

One thousand three hundred ten students met the inclusion criteria and 178 were excluded for a final study population of 1132 (86%). The average debt was $182,590. Average debt was not significantly different among the different specialties (P = 0.576). There was no significant difference in average debt between PC and NPC specialties (PC $182,345 ± $64,457, NPC $182,868 ± $70,420, P = 0.342). There was no correlation between average specialty income and graduation debt (Spearman’s rho = 0.021, P = 0.482).

Conclusions

At our institution, student indebtedness did not appear to affect matched medical specialty, and no correlation between debt and average specialty income was observed. Different subspecialties and residency programs interested in recruiting more students or increasing diversity may consider addressing alternative factors which may have a stronger influence on student choices.
Using concept mapping to inform the development of a transitional reintegration intervention program for formerly incarcerated people with HIV
Authors: Antoniou Tony , Mishra Sharmistha , Matheson Flora , Smith-Merrill Diane , Challacombe Laurel , Rowe Janet , DiCenso Anne Marie , Kouyoumdjian Fiona G. , Wobeser Wendy , Kendall Claire , Loutfy Mona , Tsang Jenkin , Kanee Lauren , Strike Carol
Published: October 2019

Background

Accessing HIV-related care is challenging for formerly incarcerated people with HIV. Interventions informed by the perspectives of these individuals could facilitate engagement with care and address competing priorities that may act as barriers to this process.

Methods

We used concept mapping to identify and prioritize the main obstacles to engaging with HIV-related care following prison release. In brainstorming sessions, formerly incarcerated people with HIV generated responses to a focused prompt regarding the main barriers to reengaging with care. These were consolidated in 35 statements. Next, participants sorted the consolidated list of responses into groups and rated each from lowest to highest in terms of its importance and feasibility of being addressed. We used cluster analysis to generate concept maps that were interpreted with participants.

Results

Overall, 39 participants participated in brainstorming sessions, among whom 18 returned for rating and sorting. Following analysis, a seven-cluster map was generated, with participants rating the ‘Practical Considerations’ (e.g. lack of transportation from prison) and ‘Survival Needs’ (e.g. securing housing and food) clusters as most important. Although ratings were generally similar between women and men, women assigned greater importance to barriers related to reconnecting with children.

Conclusions

Using concept mapping, we worked with formerly incarcerated people with HIV to identify and prioritize key challenges related to accessing health and social services following prison release. Transitional intervention programs should include programs and processes that address meeting basic subsistence needs and overcoming logistical barriers related to community re-entry.
PIK3CA-CDKN2A clonal evolution in metastatic breast cancer and multiple points cell-free DNA analysis
Authors: Palmieri Maria , Baldassarri Margherita , Fava Francesca , Fabbiani Alessandra , Campennì Giuseppe Maria , Mencarelli Maria Antonietta , Tita Rossella , Marsili Stefania , Renieri Alessandra , Frullanti Elisa
Published: October 2019

Background

Daily experience tells us that breast cancer can be controlled using standard protocols up to the advent of a relapse. Now new frontiers in precision medicine like liquid biopsy of cell free DNA (cfDNA) give us the possibility to understand cancer evolution and pick up the key mutation on specific cancer driver gene. However, tight schedule of standardized protocol may impair the use of personalized experimental drugs in a timely therapeutic window.

Main body

Here, using a combination of deep next generation sequencing and cfDNA liquid biopsy, we demonstrated that it is possible to monitor cancer relapse over time. We showed for the first time the exact correspondence from the increasing clonal expansion and clinical worsening of metastatic breast cancer.

Conclusion

Thanks to liquid biopsy may be possible to introduce new experimental drugs in the correct therapeutic window which would lead in the near future to an effective treatment which otherwise remains challenging.
Tumor vasculature remolding by thalidomide increases delivery and efficacy of cisplatin
Authors: Shen Yanwei , Li Shuting , Wang Xin , Wang Mengying , Tian Qi , Yang Jiao , Wang Jichang , Wang Biyuan , Liu Peijun , Yang Jin
Published: October 2019

Background

A promising strategy to overcome the chemoresistance is the tumor blood vessel normalization, which restores the physiological perfusion and oxygenation of tumor vasculature. Thalidomide (Thal) has been shown to increase the anti-tumor effect of chemotherapy agents in solid tumors. However, it is not yet known whether the synergistic effect of Thal combined with other cytotoxic drugs is attributable to tumor vascular normalization.

Methods

We used two homograft mice models (4 T1 breast tumor model and CT26 colorectal tumor model) to investigate the effect of Thal on tumor growth, microvessel density, vascular physiology, vascular maturity and function, drug delivery and chemosensitivity. Immunofluorescence, immunohistochemistry and scanning electron microscopy were performed to determine the vessel changes. Protein array assay, qPCR and western blotting were used to detect the molecular mechanism by which Thal regulates tumor vascular.

Results

Here we report that Thal potently suppressed tumor growth, angiogenesis, hypoxia, and vascular permeability in animal models. Thal also induced a regular monolayer of endothelial cells in tumor vessels, inhibiting vascular instability, and normalized tumor vessels by increasing vascular maturity, pericyte coverage and endothelial junctions. The tumor vessel stabilization effect of Thal resulted in a decrease in tumor vessel tortuosity and leakage, and increased vessel thickness and tumor perfusion. Eventually, the delivery of cisplatin was highly enhanced through the normalized tumor vasculature, thus resulting in profound anti-tumor and anti-metastatic effects. Mechanistically, the effects of Thal on tumor vessels were caused in part by its capability to correct the imbalance between pro-angiogenic factors and anti-angiogenic factors.

Conclusions

Our findings provide direct evidence that Thal remodels the abnormal tumor vessel system into a normalized vasculature. Our results may lay solid foundation for the development of Thal as a novel candidate agent to maximize the therapeutic efficacy of chemotherapeutic drugs for solid tumors.
Methylation-mediated silencing of miR-133a-3p promotes breast cancer cell migration and stemness via miR-133a-3p/MAML1/DNMT3A positive feedback loop
Authors: Shi Wanyue , Tang Tingting , Li Xinping , Deng Siwei , Li Ruiyi , Wang Yingshan , Wang Yifei , Xia Tiansong , Zhang Yanfeng , Zen Ke , Jin Liang , Pan Yi
Published: October 2019

Background

miR-133a-3p has been recently discovered to be down-regulated in various human malignancies, including breast cancer, and reduced miR-133a-3p levels have been significantly associated with breast cancer cell growth and invasion. However, the regulatory mechanisms leading to abnormal expression of miR-133a-3p in breast cancer remain obscure.

Methods

qRT-PCR was applied to detect the expression of miR-133a-3p in breast cancer tissues and cell lines. Bisulfite sequencing was used to detect the degree of methylation of the miR-133a-3p promoter. The effects of miR-133a-3p on breast cancer in vitro were examined by cell proliferation assay, transwell assay, flow cytometry, and western blotting. Bioinformatic analysis, dual-luciferase assay and RIP assay were employed to identify the interaction between miR-133a-3p and MAML1. A xenograft model was used to show the metastasis of breast cancer cells.

Results

We confirmed that miR-133a-3p was silenced by DNA hypermethylation in breast cancer cell lines and tissues, which predicted poor prognosis in breast cancer patients, and reducing miR-133a-3p expression led to a significant increase in the migration, invasion, proliferation, and stemness of breast cancer cells in vitro. Mastermind-like transcriptional coactivator 1 (MAML1) was confirmed to be a target of miR-133a-3p involved in regulating breast cancer metastasis both in vitro and in vivo. Moreover, a series of investigations indicated that MAML1 initiated a positive feedback loop, which could up-regulate DNA methyltransferase 3A (DNMT3A) to promote hypermethylation of the miR-133a-3p promoter.

Conclusion

Taken together, our findings revealed a novel miR-133a-3p/MAML1/DNMT3A positive feedback loop in breast cancer cells, which may become a potential therapeutic target for breast cancer.
Variation in accessibility of the population to an Emergency Medical Communication Centre: a multicentre observational study
Authors: Penverne Yann , Leclere Brice , Lecarpentier Eric , Marx Jean-Sébastien , Gicquel Benjamin , Goix Laurent , Reuter Paul-Georges
Published: October 2019

Background

Access to an Emergency Medical Communication Centre is essential for the population in emergency situations. Handling inbound calls without delay requires managing activity, process and outcome measures of the Emergency Medical Communication Centre to improve the workforce management and the level of service. France is facing political decisions on the evolution of the organisation of Emergency Medical Communication Centres to improve accessibility for the population. First, we aim to describe the variation in activity between Emergency Medical Communication Centres, and second, to explore the correlation between process measures and outcome measures.

Methods

Using telephone activity data extraction, we conducted an observational multicentre study of six French Emergency Medical Communication Centres from 1 July 2016 to 30 June 2017. We described the activity (number of incoming calls, call rate per 1000 inhabitants), process measure (agent occupation rate), and outcome measure (number of calls answered within 20 s) by hourly range and estimated the correlation between them according to the structural equation methods.

Results

A total of 52,542 h of activity were analysed, during which 2,544,254 calls were received. The annual Emergency Medical Communication Centre call rate was 285.5 [95% CI: 285.2–285.8] per 1000 inhabitants. The average hourly number of calls ranged from 29 to 61 and the call-handled rate from 75 to 98%. There are variations in activity between Emergency Medical Communication Centres. The mean agent occupation rate was correlated with the quality of service at 20 s (coefficient at − 0.54). The number of incoming calls per agent was correlated with the mean occupation rate (coefficient at 0.67). Correlation coefficients varied according to the centres and existed between different process measures.

Conclusions

The activity dynamics of the six Emergency Medical Communication Centres are not identical. This variability, illustrating the particularity of each centre, must be accurately assessed and should be taken into account in managerial considerations. The call taker occupation rate is the leverage in the workforce management to improve the population accessibility.
RaGOO: fast and accurate reference-guided scaffolding of draft genomes
Authors: Alonge Michael , Soyk Sebastian , Ramakrishnan Srividya , Wang Xingang , Goodwin Sara , Sedlazeck Fritz J. , Lippman Zachary B. , Schatz Michael C.
Published: October 2019

We present RaGOO, a reference-guided contig ordering and orienting tool that leverages the speed and sensitivity of Minimap2 to accurately achieve chromosome-scale assemblies in minutes. After the pseudomolecules are constructed, RaGOO identifies structural variants, including those spanning sequencing gaps. We show that RaGOO accurately orders and orients 3 de novo tomato genome assemblies, including the widely used M82 reference cultivar. We then demonstrate the scalability and utility of RaGOO with a pan-genome analysis of 103 Arabidopsis thaliana accessions by examining the structural variants detected in the newly assembled pseudomolecules. RaGOO is available open source at https://github.com/malonge/RaGOO.
Correction to: Sample size estimation for randomised controlled trials with repeated assessment of patient-reported outcomes: what correlation between baseline and follow-up outcomes should we assume?
Authors: Walters Stephen J. , Jacques Richard M. , dos Anjos Henriques-Cadby Inês Bonacho , Candlish Jane , Totton Nikki , Xian Mica Teo Shu
Published: October 2019

Following publication of the original article [1], we have been notified that one of an error in the Conclusions section of the Abstract.
Correction to: Does a Screening Trial for Spinal Cord Stimulation in Patients with Chronic Pain of Neuropathic Origin have Clinical Utility and Cost-Effectiveness? (TRIAL-STIM Study): study protocol for a randomised controlled trial
Authors: Eldabe Sam , Gulve Ashish , Thomson Simon , Baranidharan Ganesan , Duarte Rui , Jowett Susan , Sandhu Harbinder , Chadwick Raymond , Brookes Morag , Tariq Anisah , Earle Jenny , Bell Jill , Kansal Anu , Rhodes Shelley , Taylor Rod S.
Published: October 2019

Following publication of the original article [1], we have been notified that the final specification of randomisation implemented in the study is slightly different to that stated in the protocol and needs to be corrected as follows:
Prevention of postpartum suicidality in Israel
Authors: Klomek Anat Brunstein
Published: October 2019

Postpartum suicidality in Israel had not been systematically studied until the recent important investigation by Glasser and colleagues. The authors review rates, trends, and characteristics of postpartum women who considered, attempted, or completed suicide in Israel. This commentary argues that, although postpartum suicidality is relatively rare, it is extremely tragic—not just for the women, but for the entire family and community. The main aim of this commentary is to emphasize that preventive efforts should continue and expand, especially among at-risk groups. At-risk groups include the youngest age group, postpartum Arab women, and postpartum former Soviet Union immigrants. Identification of women at risk or suffering from postpartum depression (PPD) is mandated in Israel. Efforts should include broader screening for various types of suicide ideation and behavior. Assessments should specifically include passive suicide ideation, active suicide ideation with method, intent, and plan, as well as various types of suicide attempts and preparatory behaviors. In addition, specific interventions formulated on evidence-based psychotherapies should be provided in family practice, obstetric, and pediatric settings. These settings are less stigmatized in comparison to mental health settings. Potential therapies can be (among others) Cognitive Behavioral Therapy (CBT) and Interpersonal Psychotherapy (IPT), which are effective in preventing perinatal depression.
Use of ultrasound-measured internal jugular vein collapsibility index to determine static intracardiac pressures in patients with presumed pulmonary hypertension
Authors: Parikh Raj , Spring Matthew , Weinberg Janice , Reardon Christine C. , Farber Harrison W.
Published: October 2019

Background

Bedside ultrasound helps to estimate volume status in critically ill patients and has traditionally relied on diameter, respiratory variation, and collapsibility of the inferior vena cava (IVC) to reflect fluid status. We evaluated collapsibility of the internal jugular vein (IJ) with ultrasound and correlated it with concomitant right heart catheterization (RHC) measurements in patients with presumed pulmonary hypertension.

Methods and results

We studied 71 patients undergoing RHC for evaluation of pulmonary hypertension. Using two-dimensional ultrasound (Sonosite, Washington, USA), we measured the diameter of the IJ at rest, during respiratory variation, and during manual compression. Collapsibility index during respiration (respiratory CI) and during manual compression (compression CI) was calculated. We correlated mean right atrial pressure (mRAP) and pulmonary artery occlusion pressure (PAOP) defined by RHC measurements with respiratory and compression CI. A secondary goal was examining correlations between CI calculations and B-type natriuretic peptide (BNP) levels. Baseline characteristics demonstrated female predominance (n = 51; 71.8%), mean age 59.5 years, and BMI 27.3. There were significant correlations between decrease in compression CI and increase in both mRAP (Spearman: − 0.43;pvalue = 0.0002) and PAOP (Spearman: − 0.35;pvalue = 0.0027). In contrast, there was no significant correlation between respiratory CI and either mRAP (Spearman: − 0.14;pvalue = 0.35) or PAOP (Spearman:− 0.12;pvalue = 0.31). We also observed significant negative correlation between compression CI and BNP (Spearman: − 0.31;pvalue = 0.01) but not between respiratory CI and BNP (Spearman: − 0.12;pvalue = 0.35).

Conclusion

Increasing use of ultrasound has led to innovative techniques for estimating volume status. While prior ultrasound studies have used clinical parameters to estimate fluid status, our study used RHC measurements and demonstrated that compression CI potentially reflects directly measured mRAP and PAOP.
Protocol for a systematic review and network meta-analysis of the management of new onset atrial fibrillation in critically unwell adult patients
Authors: Johnston Brian W. , Hill Ruaraidh , Duarte Rui , Chean Chung Shen , McAuley Danny F. , Blackwood Bronagh , Pace Nathan , Welters Ingeborg D.
Published: October 2019

Background

New onset atrial fibrillation is the most commonly encountered arrhythmia in critically unwell patients with a reported incidence of 4% to 29%. The occurrence of new onset atrial fibrillation may precipitate acute heart failure and lead to thromboembolic complications as well as being associated with increased in-hospital and in intensive care unit (ICU) mortality. Despite being common, much of our current knowledge regarding the treatment of new onset atrial fibrillation comes from patients with chronic atrial fibrillation or post cardiac surgery. It is unclear if management strategies in these patient cohorts can be applied to new onset atrial fibrillation in the general ICU. This protocol for a systematic review and network meta-analysis aims to address this uncertainty and define what is the most effective management strategy for the treatment of new onset atrial fibrillation (NOAF) in acutely unwell adult patients.

Methods

In this systematic review and network meta-analysis, we plan to search electronic databases (Cochrane Central Register of Controlled Trials [CENTRAL], MEDLINE, EMBASE, Science Citation Index Expanded on Web of Science and relevant trial registries) for relevant randomised and non-randomised trials. Citations will be reviewed by title, abstract and full text by two independent reviewers and disagreement resolved by discussion and a third independent reviewer, if necessary. The Cochrane Risk of Bias tool will be used to assess risk of bias in randomised trials and the Risk of Bias in Nonrandomised Studies of Interventions (ROBINS-I) tool will be used for non-randomised studies. Statistical analysis will be carried out using R package meta and netmeta. We will first conduct a pairwise meta-analysis. If conditions for indirect comparison are satisfied and suitable data are available, we will conduct network meta-analysis using frequentist methodology. Treatments will be ranked according to efficacy with associated P-scores. We will assess the quality of the evidence in the pairwise using GRADE methodology and network meta-analysis comparisons in the CINeMA module in R package meta.

Discussion

Our review will be the first to assess direct and indirect evidence to assess the efficacy and rank the treatments available for new onset atrial fibrillation in critically unwell patients. Our review findings will be applicable to the care of people in a range of acute settings including, ICU, the emergency department and acute medical units.

Systematic review registration

PROSPERO registry number: CRD42019121739.
Axial–Flexural Interaction in FRP-Wrapped RC Columns
Authors: Al-Nimry Hanan Suliman , Al-Rabadi Rabi Amer
Published: October 2019

The study reported herein aims at investigating the behavior of medium-scale circular reinforced concrete columns wrapped with fiber reinforced polymer (FRP) sheets under concentric and eccentric axial loads. The experimental program was devised to assess the effects of loading conditions, absence/presence of an FRP jacket as well as the FRP wrapping system. To achieve the study objectives, four column groups were tested under axial compression at 0, 25, 50 and 65 mm loading eccentricities corresponding to eccentricity-to-diameter ratios of 0, 0.13, 0.26 and 0.34, respectively. Specimens in a fifth group were tested in pure bending simulating axial compression at infinite loading eccentricities. Three column subcategories were tested under each of the 5 loading eccentricities: unwrapped; wrapped with one ply of hoop FRP sheets; and wrapped with two FRP plies with fibers oriented at 0 and 90° to the longitudinal column axis thereby providing externally-bonded longitudinal reinforcement and hoop confinement, respectively. Tests confirmed that FRP confinement enhances the axial–flexural column resistance even at large eccentricities that exceed the balanced state of unconfined columns. Although axial column resistance decreased with increasing bending moments, relative enhancements (25–35%) in axial resistance provided by FRP confinement were found to be more significant under eccentric loading than in pure compression. Compared to hoop FRP-confined columns, using additional longitudinal sheets resulted in minor (7–9%) but stable enhancements in axial resistance that were unaffected by the increase in loading eccentricity. The FRP hoop wraps had a minor effect on the flexural resistance of specimens tested in pure bending but managed to double their resistance when combined with the externally-bonded longitudinal FRP sheets. Finally, three stress–strain models of FRP-confined concrete were used in conventional section analysis to assess the axial–flexural interaction in the FRP-jacketed columns. Strength predictions made using the stress–strain model proposed in ACI 440.2R-17 design guidelines did not agree with the test results of the eccentrically-loaded columns and underestimated the moment resistance at a given axial force even when considering higher confinement ratios than those permitted by the guidelines. Strength predictions made using eccentricity-dependent stress–strain models showed better results especially when accounting for the increase in ultimate axial strains under eccentric loading.
[18F]-AV-1451 binding profile in chronic traumatic encephalopathy: a postmortem case series
Authors: Marquié Marta , Agüero Cinthya , Amaral Ana C. , Villarejo-Galende Alberto , Ramanan Prianca , Chong Michael Siao Tick , Sáez-Calveras Nil , Bennett Rachel E. , Verwer Eline E. , Kim Sally Ji Who , Dhaynaut Maeva , Alvarez Victor E. , Johnson Keith A. , McKee Ann C. , Frosch Matthew P. , Gómez-Isla Teresa
Published: October 2019

Introduction

Chronic traumatic encephalopathy (CTE) is a tauopathy associated to repetitive head trauma. There are no validated in vivo biomarkers of CTE and a definite diagnosis can only be made at autopsy. Recent studies have shown that positron emission tomography (PET) tracer AV-1451 (Flortaucipir) exhibits high binding affinity for paired helical filament (PHF)-tau aggregates in Alzheimer (AD) brains but relatively low affinity for tau lesions in other tauopathies like temporal lobal degeneration (FTLD)-tau, progressive supranuclear palsy (PSP) or corticobasal degeneration (CBD). Little is known, however, about the binding profile of this ligand to the tau-containing lesions of CTE.

Objective

To study the binding properties of [18F]-AV-1451 on pathologically confirmed CTE postmortem brain tissue samples.

Methods

We performed [18F]-AV-1451 phosphor screen and high resolution autoradiography, quantitative tau measurements by immunohistochemistry and Western blot and tau seeding activity assays in brain blocks containing hippocampus, superior temporal cortex, superior frontal cortex, inferior parietal cortex and occipital cortex from 5 cases of CTE, across the stages of disease: stage II-III (n = 1), stage III (n = 3), and stage IV (n = 1). Importantly, low or no concomitant classic AD pathology was present in these brains.

Results

Despite the presence of abundant tau aggregates in multiple regions in all CTE brains, only faint or no [18F]-AV-1451 binding signal could be detected by autoradiography. The only exception was the presence of a strong signal confined to the region of the choroid plexus and the meninges in two of the five cases. Tau immunostaining and Thioflavin-S staining ruled out the presence of tau aggregates in those regions. High resolution nuclear emulsion autoradiography revealed the presence of leptomeningeal melanocytes as the histologic source of this off-target binding. Levels of abnormally hyperphosphorylated tau species, as detected by Western Blotting, and tau seeding activity were both found to be lower in extracts from cases CTE when compared to AD.

Conclusion

AV-1451 may have limited utility for in vivo selective and reliable detection of tau aggregates in CTE. The existence of disease-specific tau conformations may likely explain the differential binding affinity of this tracer for tau lesions in different tauopathies.
Occurrence of F region echoes for the polar cap SuperDARN radars
Authors: Koustov Alexander V. , Ullrich Sydney , Ponomarenko Pavlo V. , Nishitani Nozomu , Marcucci Federica M. , Bristow William A.
Published: October 2019

Observations by six Super Dual Auroral Radar Network (SuperDARN) polar cap radars, three in the northern hemisphere and three in the southern hemispheres, are considered to assess F region echo occurrence rates over solar, season, and day cycles and to establish relationship between the echo occurrence rate and the background electron density and plasma flow velocity magnitude. The echo occurrence rate is shown to increase toward the solar cycle maximum, more distinctly on the nightside, consistent with a general trend of the background electron density. Over the last 5 years, the echo occurrence rates decline at a rate of 5–10% per year. The pattern of seasonal and diurnal variations in echo occurrence is found to be consistent with previous SuperDARN publications. Minor dips in echo occurrence rate are observed in winter solstices, and these are related to an overall decrease in the electron density. In most of the time sectors, the echo occurrence rate increases with the electron density but only up to a certain threshold value after which the dependence saturates. The level of the saturation depends on season, local time, and average plasma flow velocity magnitude. For the summer daytime observations, the echo occurrence rate correlates with variations of both electron density and plasma flow velocity magnitude.
Prescribed burning in a mediterranean-climate region mitigates the disturbance by bushfire to a critical food resource for an endangered bird, the Carnaby’s cockatoo
Authors: Densmore Valerie S. , Clingan Emma S.
Published: October 2019

Background

Prescribed burning is used to reduce fire hazard in highly flammable vegetation types, including Banksia L.f. woodland that occurs on the Swan Coastal Plain (SCP), Western Australia, Australia. The 2016 census recorded well over 1.9 million people living on the SCP, which also encompasses Perth, the fourth largest city in Australia. Banksia woodland is prone to frequent ignitions that can cause extensive bushfires that consume canopy-stored banksia seeds, a critical food resource for an endangered bird, the Carnaby’s cockatoo (Calyptorynchus latirostris, Carnaby 1948). The time needed for banksias to reach maturity and maximum seed production is several years longer than the typical interval between prescribed burns. We compared prescribed burns to bushfires and unburned sites at three locations in banksia woodland to determine whether low-intensity prescribed burns affect the number of adult banksias and their seed production. Study sites were matched to the same vegetation complex, fire regime, and time-since-fire to isolate fire intensity as a variable.

Results

Headfire rates of spread and differenced normalized burn ratios indicated that prescribed burning was generally of a much lower intensity than bushfire. The percentage survival of adult banksias and their production of cones and follicles (seeds) did not decrease during the first three years following a prescribed burn. However, survival and seed production were significantly diminished followed high-intensity bushfire. Thus, carrying capacity for Carnaby’s cockatoo was unchanged by prescribed burning but decreased markedly following bushfire in banksia woodland.

Conclusions

These results suggest that prescribed burning is markedly different from bushfire when considering appropriate fire intervals to conserve canopy habitats in fire-resilient vegetation communities. Therefore, low-intensity prescribed burning represents a viable management tool to reduce the frequency and extent of bushfire impacts on banksia woodland and Carnaby’s cockatoo.
Disguising Lies—Image Concerns and Partial Lying in Cheating Games
Authors: Khalmetski Kiryl , Sliwka Dirk
Published: October 2019

We study equilibrium reporting behavior in cheating games when agents have a fixed cost of lying and image concerns not to be perceived as a liar. We show that equilibria naturally arise in which agents with low costs of lying randomize among a set of the highest potential reports. Such equilibria induce a distribution of reports in line with observed experimental patterns. We also find that higher image concerns lead to an increase in the range of reported lies, while the effect of the fixed cost of lying is the opposite. (JEL C72, D82, Z13)
Learning Theory and Heterogeneous Play in a Signaling-Game Experiment
Authors: Fudenberg Drew , Vespa Emanuel
Published: October 2019

We study the effect of how types are assigned to participants in a signaling-game experiment. The sender has two actions, In and Out, and two types. In one treatment, types are i.i.d. in every period, and senders gather experience with both types. In the other, types are assigned once-and-for-all, and feedback is type specific. The theory of learning in games predicts that the non-Nash but self-confirming equilibrium where some fraction of types play Out can persist in the fixed-type treatment but not when types are i.i.d. Our results confirm that more senders do play Out in the fixed-type treatment. (JEL C92, D82, D83)
Neurogenic bowel dysfunction
Authors: Emmanuel Anton
Published: October 2019

The symptoms of neurogenic bowel dysfunction (NBD) comprise constipation and fecal incontinence. These have a major impact on quality of life and dignity. Bowel symptoms occur in the majority of patients with chronic neurological diseases like multiple sclerosis, spinal cord injury, and Parkinson’s disease. Management relies on obtaining a careful bowel history, including assessment of bowel function prior to the onset of neurological symptoms. Objective measures of NBD are available and important in terms of monitoring response for what are often intensely personal and difficult-to-elicit symptoms. Conservative management begins by establishing an effective and regular bowel regime by optimizing diet and laxative use. If this is insufficient, as seen in about half of patients, transanal irrigation has been shown to reduce NBD symptoms and improve quality of life. Failing that, there are more invasive surgical options available. This review aims to provide practical guidance for the clinician who encounters these patients, focusing on a stepwise approach to assessment, interventions, and monitoring.