bluuebunny/crossref_metadata_2025 huggingface dataset:
What factors counteract the mid-term survival following endovascular repair of abdominal aortic aneurysms?
Authors: Iscan Hakkı Zafer , Unal Ertekin , Akkaya Boğaçhan , Civelek İsa , Karahan Mehmet , Celikten Ece , Askin Goktan , MAVIOGLU LEVENT , Ozatik Mehmet Ali
Published: March 2022

Background.Endovascular aortic aneurysm repair (EVAR) for abdominal
aortic aneurysm (AAA) is increasingly used and become the standard
treatment option for AAA. The aim of the current study was to evaluate
the outcomes and predictors of survival of endovascular treatment of AAA
at the short and medium-term. Methods.A total of 222 patients having
endovascular AAA repair between January 2013 and December 2019 by the
same surgical team were included in the study. Patient demographics,
perioperative and follow-up data including mortality,complications and
need for secondary intervention were collected.Primary endpoint was
all-cause mortality.Kaplan-Meier analysis was conducted for survival and
Cox regression models were assessed for predictors of survival. Results.
Median age was 70 years with male predominance(202 patients,91%).
Thirty-day mortality was 1.8%. Median follow-up to the primary endpoint
was 20 months(range,1 to 80 months). Survival rates at one, three and
five years were 93.5%,81.4% and 62.2% respectively. Freedom from
secondary intervention rates were 95.5% at one year,88.7% at three
years and 82.1% at five years. Cox proportional hazard models showed
that preoperative creatinine levels ≥1.8 mg/dl(hazard ratio (HR) 2.68,
95%CI1.21-6.42, p=0.027), hemoglobin levels <10 gr/dl (HR
3.38 95%CI 1.16-9.90,p=0.026), ejection fraction < 30% (HR
5.67,95%CI1.29-24.86,p=0.021)and AAA diamete≥6.0 cm(HR
2.20,95%CI1.01-4.81,p=0.049)were independently associated with mid-term
survival. Conclusion.EVAR is a safe procedure with low postoperative
morbidity and mortality. This study confirms that the mid-term survival
and results are favorable.However, the analyzed factors in this study
that predict reduced survival(high preoperative creatinine,ow
hemoglobin,low ejection fraction and larger aneurysms) should be judged
when planning EVAR.
High Selective Separation of Heavy Metals in Wastewater by Shear Induced Orderly Dissociation Coupling with Ultraﬁltra
Authors: zhou han , Qiu Yunren , zhang qiang , chen yuxin
Published: March 2022

Heavy metals M (Cr (III), Ni (II), Cu (II), Zn (II)) in nickel plating
wastewater were recovered by complexation-ultrafiltration (C-UF) with
the complexant PMA. The important factors pH and PMA/M mass ratio (P/M)
on metals rejections were investigated, and all rejections could reach
to 98% at pH 6.0 and P/M 8. Besides, the shear rate () distribution on
the membrane surface was analyzed by CFD revealed that  increased along
the radius.The criticl shear rates (c) of PMA-M complexes were
calculated to judge the shear stability of different complexes,and c of
PMA-Cr, PMA-Ni, PMA-Cu and PMA-Zn complexes were 1.14×105, 1.48×105,
2.07×105 and 1.21×104 s-1 ,respectively. Furthermore, the pairwise
separation coefficients of metals were calculated, and the maximum of
βZn/Cr, βCr/Ni and βNi/Cu are 95.5, 42.0 and 47.3. The high selective
separation of heavy metals and PMA were achieved by shear induced
orderly dissociation coupling with ultrafiltration（SIOD-UF）.
Pulmonary Embolism and Wilms' Tumor, Can it Be Any Worse?
Authors: Alzhrani Abdulrhman , Baothman Abdullah
Published: March 2022

It is common for Wilms tumor to invade the inferior vena cava and right
atrium, but a massive pulmonary embolism is rare. This case reports
describes an 8-year-old male patient who presented to an outpatient
clinic with mild pain and abdominal mass. A left renal mass with
extension of an inferior vena cava thrombus was seen on abdominal CT,
suggesting a Wilms tumor. An exploratory laparotomy biopsy was
scheduled, but not completed because the patient’s health suddenly
deteriorated, and he died despite high-quality cardiopulmonary
resuscitation. A massive pulmonary embolism was found to cause a sudden
and fatal cardiac arrest.
A modification on the exponential cubic B-spline for numerical simulation of hyperbolic telegraph equations
Authors: HAGHIGHI Ahmad , Rahimian Forouzan , Roohi Majid
Published: March 2022

In this paper, the differential quadrature method is implemented to find
the numerical solution of two and three-dimensional telegraphic
equations‏ with Dirichlet and Neumann’s boundary values. This technique
is according to exponential cubic B-spline functions. So, a modification
on the exponential cubic B- spline is applied in order to use as a basis
function in the DQ method. Therefore, the Telegraph equation (TE) is
altered to a system of ordinary differential equations (ODEs). The
optimized form of Runge-Kutta scheme has been implemented by four-stage
and three-order strong stability preserving (SSP-RK43) to solve the
resulting system of ODEs. We examined the correctness and applicability
of this method by four examples of the TE.
Estimation of uncertainty in enzymatic kinetics from stochastic simulation
Authors: carrero javier , Prado Oscar , Valencia Anderson
Published: March 2022

Stochastic simulation of enzymatic kinetics is uncommon, but it can
bring more insight to the results obtained with the usual deterministic
simulation based on the integration of differential equations. This work
covers the stochastic simulation of mass action and Michaelis-Menten
kinetic models applied to generic examples of four enzymatic kinetic
cases, with and without inhibition. For each case the deterministic
model was translated to a stochastic formulation based on numbers of
molecules instead of concentrations. The simulations were done applying
the Gillespie algorithm, and the uncertainty of the results was
estimated with the standard deviation, calculated from many realizations
(repetitions) of the stochastic simulations for each case. The
uncertainty of the concentration results is related with the number of
molecules in the initial simulation setting. It was also found that a
minimum number of realizations is enough to estimate the standard
deviation of the results. However, due to the nature of the stochastic
method the uncertainty of its results varies through the simulation. In
sum, the uncertainty of enzyme kinetics can be estimated
\emph{in-silico} with stochastic simulation.
Perilla seed allergy: A systematic analysis of clinical and immunological profiles
Authors: Jeong Kyunguk , Lee So Yeon , Jeon Se-Ah , Gantulga Purevsan , Nam Jin Young , Hong Soo-Jong , Lee Sooyoung
Published: March 2022

Background Perilla seeds have been shown to cause immediate allergic
reactions. However, reports on perilla seed allergies are limited to a
few case reports, and there is currently no diagnostic test for such
allergies. Our objective was to analyze the clinical and immunological
characteristics of perilla seed allergy and to identify allergens for
the development of diagnostic methods. Methods Twenty-two children with
clinical perilla seed allergy were enrolled from two tertiary hospitals
between September 2016 and June 2019. Using perilla seed extract, we
developed a skin prick test (SPT) reagent and an IgE enzyme-linked
immunosorbent assay (ELISA) for perilla seed allergy diagnosis. IgE
immunoblotting was performed for identifying putative allergenic
components, and amino acid composition analysis was performed using
liquid chromatography-tandem mass spectrometry (LC-MS/MS). Results The
median age of children with perilla seed allergy was 3 years, and the
proportion of children with anaphylaxis was 31.8%. Perilla seed SPT was
performed for 16 of 22 children, all of whom tested positive. On ELISA,
86.4% of children tested positive for perilla seed-specific IgE.
Proteins with molecular weights of 50, 31–35, and 14–16 kDa showed
binding with the sera of >50% of children with perilla
seed allergy. LC-MS/MS analysis of these three protein fractions
indicated 8 putative proteins, including perilla oleosin (Accession No.
9963891), to be allergens. Conclusion We reported the clinical
characteristics and immunological profiles of 22 children with perilla
seed allergy and suggested oleosin as one of the major allergens in
perilla seeds.
The effects of birth spacing after cesarean delivery on pregnancy outcomes: a retrospective cohort study
Authors: Xu Qin , Ye Lei , Wang Qilin , Xia Wei , Wei Xiaohong , Zhou Rong
Published: March 2022

Objective: To examine the relationship between interpregnancy interval
(IPI) after previous cesarean section (CS) and perinatal outcomes.
Design: Retrospective cohort study. Setting: West China Second
University Hospital, Sichuan University, China. Population: A total of
1854 women with a history of CS who delivered from January 2016 to
December 2016. Methods: With an IPI of 24-59 months as the reference,
the associations between various IPIs (<24, 60-119, and ≥120
months) and perinatal outcomes were examined by multivariate logistic
regression analysis with multiple models. Main outcome measures: Adverse
maternal and fetal outcomes of different IPIs after CS. Results: IPI
<24 months significantly increased the risk of anemia in late
pregnancy (aOR 2.09, 95% CI 1.21-2.62, p = 0.008). IPI <24
months was associated with a higher risk for incomplete uterine rupture
(OR 1.30, 95% CI 1.05-1.61), IPI ≥60 months was related to a lower risk
for incomplete uterine rupture (IPI = 60-119 months: OR 0.77, 95% CI
0.62-0.95; IPI ≥120 months, OR 0.59, 95% CI 0.38-1.08), and women with
IPI ≥120 months were more likely to develop gestational hypertension
(GHP) (p = 0.036) and gestational diabetes mellitus (GDM) (p = 0.001).
These effects became nonsignificant after adjusting possible
confounders. Conclusion: IPI <24 months is associated with a
higher risk for anemia in late pregnancy. IPI may combine with other
factors to affect GHP, GDM, and uterine rupture in the subsequent
pregnancy after previous CS. Funding: National Natural Science
Foundation of China (No. 81571465). Keywords: Adverse pregnancy
outcomes, Birth spacing, Cesarean delivery.
Formulation and biophysical characterization of SNARE’s like the behavior of human α-lactalbumin oleic acid (HALOA) complex as an anticancerous agent against chronic myeloid leukemia.
Authors: singh vivek , Singh Ranjana , Kumar Dinesh , Mahdi Abbas , Tripathi A.
Published: March 2022

Encapsulation of apo human alpha-lactalbumin (α-LA) within oleic acid
(OA) attains similar morphology as SNARE’s, which forms human
α-lactalbumin-oleic acid (HALOA) complex by altering the methodology
from previous studies. Firstly the native α-LA was treated with EDTA to
remove Ca2+ ions (ICP-OES, and Arsenazo III) which leads to unfolding
for maintenance of an apo structure, and was directly mixed with OA in a
specific ratio. Further, the structural variations from apo to the
complex were elucidated by circular dichroism (far UV-CD; 190-260 nm and
near UV-CD; 260-340 nm) which shows that it consists of a majority of
turns and β-sheet structure. ANS (1-anilino-8-naphthalene sulfonate) dye
shows maximum fluorescence intensity because it strongly binds with the
complex due to the availability of hydrophobic patches. The masking
effect of OA was validated by SDS-PAGE where no band was found in a
complex lane, which is also confirmed by NMR spectroscopy that indicates
a loss in NMR signal in HALOA complex after regulated addition of OA.
The HALOA complex was further confirmed by TEM where it shows a range
around 500 nm which is structurally and morphologically similar to
SNARE’s. This new structural variant complex offers antitumor activity
on K562 cells by rectifying molecular domains (IL-8, Survivin, and Total
antioxidant) and induces apoptosis by DNA fragmentation, but it does not
show any apoptotic activity against NIH cells. Overall the formulated
complex shows SNARE’s like behavior, and it might be a promising
candidate as an antitumor agent with lower toxicity and maximum
bioavailability.
Building Seismic Damage Information Extraction of Polarimetric SAR with Convolution Neural Network
Authors: xiao lai , ZHAI WEI , Washaya Prosper
Published: March 2022

Rapid emergency rescue measures are essential in reducing losses
resulting from disasters. With the development of science and
technology, remote sensing technology is gradually applied to emergency
rescue work, especially SAR remote sensing technology, with its
advantages of all-weather and all-time observation, which play an
important role in emergency rescue. In this paper, we make use of the
Polarization information and texture information of the full
Polarimetric SAR(PolSAR) remote sensing image after the Yushu earthquake
to accurately extract information of intact and collapsed buildings.
Firstly, we separately extract the ridge and hillside information form
(1-H)(1-A) and Yamaguchi Decomposition by method of CNN (Convolution
Neural Network). Secondly, we successfully extract building area (Intact
Building Area +Non-Building Area) combine Homogeneity and Second Moment
based on previous information of ridge and hillside. Finally, extract
the intact building and collapsed building from building area based on
Anisotropy and Correlation by method of CNN (Convolution Neural Network)
again. The accuracy of extractive information is 99.12% by method of
CNN.
Solvability for generalized non-linear 2D functional integral equations
Authors: Singh Soniya , Dhiman Deepak , deep Amar , Singh Bhupander , HAZARIKA BIPAN
Published: March 2022

In this article, we provide the existence result for functional integral
equations by using Petryshyn’s fixed point theorem connecting measure of
non-compactness in Banach space. The results enlarge the corresponding
results of several authors. The consequences enlarge the corresponding
results of several authors. We present fascinating examples of
equations.
A congenital brucellosis case of 34-day-old girl
Authors: Xu Dan , Li Xuejing , Cheng Beilei , Zhou Yunlian , Zhou Mingming , Gu Weizhong , Chen Zhimin , Wang Yingshuo
Published: March 2022

Brucellosis is the most common zoonotic infection over the world, caused
by bacterial genus brucella. The disease is transmitted rarely via
human-to-human transmission. Limited data support vertical transmission
of human brucellosis. Herein, we reported a case of congenital
brucellosis case. Brucella meliteusis DNA was detected by
next-generation sequencing and bacterial identifying under microscope in
mother’s placental specimen, which also proved chorioamnionitis. After
the first course of rifampicin for 6 weeks and meropenem for 2 weeks,
the disease relapsed within 3 weeks. The second course were rifampicin
and SMZ/TMP for 8 weeks. The baby was still in following-up.
Comparison of neonatal outcomes of caesarean sections performed after conversion from neuraxial to general anaesthesia with caesarean sections performed under general anaesthesia from the outset: a retrospective study
Authors: Souala-Chalet Yasmine , Verhaeghe Caroline , Corroenne Romain , Legendre Guillaume , Descamps Philippe , Hachem Hady El , Duc Flavie , Rineau Emmanuel , Lasocki Sigismond , Leger Maxime , bouet pierre-emmanuel
Published: March 2022

Objectives: To compare the neonatal morbidity of caesarean sections (CS)
performed after conversion from neuraxial (NA) to general anaesthesia
(GA) with CS performed under GA from the outset, and to assess whether
the increase in DDI in urgent and extremely urgent cases with conversion
from NA to GA increased the risk of neonatal morbidity. Design:
Retrospective cohort study. Setting: University-affiliated hospital.
Population: All CS performed under GA between 2015 and 2019. Methods &
main outcome measures: Our main criteria used for assessing neonatal
morbidity were: neonatal pH <7.10 and/or an Apgar score at 5
minutes <7. A multivariate regression analysis was performed
to adjust for gestational age, birth weight, indication of CS. Results:
We included 284 patients: 116 had a conversion from NA to GA (group 1)
and 168 had GA from the outset (group 2). There was no significant
difference in the rate of neonates having a pH<7.10 and/or
Apgar score <5 between groups 1 and 2 (17.5% Vs 26.3%,
p=0.08, respectively). Multivariate analysis showed that neonatal
morbidity was comparable between the two groups (OR=1.58; 0.83-3.05). In
very urgent CS, the mean decision-to-delivery interval (DDI) was 3
minutes longer in group 1 compared to group 2 (17 min vs 14 min,
respectively), and there was no significant difference in neonatal pH
and/or Apgar <7 at 5 minutes between the two groups (aOR=1.4;
0.5-4.3). Conclusion: The neonatal outcomes were comparable between CS
performed after conversion from NA to GA and under GA from the outset,
even in very urgent CS.
Metformin and its analogues as a therapeutic tool for COVID-19: a narrative review.
Authors: Silva Talles Bispo da , Neto Miguel , Cruz Lucas da , Rocha Matheus , Melo Mônica de , Batista Diogo , Rodrigues Amanda
Published: March 2022

The new coronavirus (Sars-Cov-2) appeared in China in late 2019 and with
it an intense search for effective pharmacological tools in the
treatment of COVID-19. This virus can cause from mild symptoms, such as
dry cough, fever and tiredness, to more severe symptoms, such as
respiratory failure and systemic shock. Part of this problem is due to
the increase in the neutrophil/lymphocyte ratio and serum levels of
several inflammatory cytokines and chemokines. Other blood markers also
deflagrate the inflammatory condition, among them C-reactive protein,
ferritin and D dimers. Additionally, the history of chronic and/or acute
hyperglycemia is an independent predictor for morbidity and mortality in
patients with severe acute respiratory syndrome. In this pandemic
scenario, numerous new and other drugs already available on the market
have become therapeutic tools. Biguanide class drugs, classically used
in the treatment of type 2 diabetes mellitus, received great notoriety
for potentially useful systemic effects in the clinic, in cardiovascular
level and against cancer. Some of their properties may be useful in the
fight against Sars-Cov-2, such as the reduction of mRNA expression
levels of inflammatory cytokines, chemokines and by the attenuation of
NF-κB activation. These actions reduce the inflammatory response in the
individual and the damage from a severe inflammatory response. Given the
morbidity and mortality, partly attributed to the cardiovascular damage
of the COVID-19, the objective of this work was to review the systemic
effects of biguanides, as well as their therapeutic potential as an
adjuvant.
Subcutaneous immunotherapy: a perspective from Peking Union Medical College Hospital
Authors: Xu Ying-Yang , Guan Kai , Yin Jia , Wang Lianglu , Zhi Yu Xiang , Sun Jin-Lu , Li Hong , Wen Li-Ping , Gu Jian-Qing , Tang Rui , Wang Zixi , Li Li-Sha , Cui Le
Published: March 2022

Background Allergen-specific immunotherapy (AIT) is the only
disease-modifying treatment for IgE mediated disease. In china, AIT has
been applied over 60 years and subcutaneous immunotherapy (SCIT) is the
major route. This study analyzed the relatively comprehensive status of
SCIT in our country. Methods Patients who initiated SCIT between January
1, 2015, and December 31, 2016 at Peking Union Medical College Hospital
were collected and their medical records from January 1, 2015, to
December 31, 2019 were obtained. The formulation and adherence of SCIT
in different age groups and regions were analyzed. Results A total of
4731 patients receiving SCIT were analyzed, including 459 children (5-12
years), 624 adolescent (13-18 years) and 3648 adults. On a per-species
allergen extract basis, multi-allergen SCIT were prescribed in 83% of
patients. Mugwort, house dust mite and firebush were most frequently
administered. On per-group allergen extract basis, 49% of SCIT were
mixing formulations and weed pollen, tree pollen and house dust mite
were most frequently used. The most common component of SCIT was mold in
children (53%), whereas weed pollen in adolescents (59%) and adults
(68%). Overall, 35% of patients completed at least 3-year SCIT.
Children had the highest adherence of SCIT, followed by adolescents and
adults (49%, 47% and 31%, respectively). Conclusions The majority of
patients were prescribed SCIT of mixing formulation. Weed pollen was the
most frequently used allergen group in SCIT, especially in Northern
China. Real-life adherence in SCIT was still low which desiderate
improvement of current procedure of SCIT.
Pregnancy outcomes in women affected by fetal alpha-thalassemia: a case control study
Authors: Li Jiangheng , Yan Jingli , Huang Yongquan , Wei Jinlu , Xie Bingyan , Jiang Wu , Zhu Maoling
Published: March 2022

Objective: To evaluate the associations between fetal α-thalassemia and
risk of adverse pregnancy outcomes. Design: Case control study. Setting:
Forty-two hospitals in Nanning, China. Participants: Pregnant women
>20 weeks of gestation. Methods: Multivariate logistic
regression analyses were performed to explore associations between fetal
α-thalassemia and adverse pregnancy outcomes. Receiver operating
characteristic curve analyses were used to assess the use of selected
factors in predicting low Apgar scores. Main Outcome and Measure:
Pregnancy outcomes of thalassemic women whose fetuses had
non-thalassemia, α-thalassemia trait or HbH disease. Results: With
thalassemic women whose fetuses were normal as the reference, fetuses in
the HbH disease group showed a higher increase in the odds of Apgar
scores being <7 at 1 minute (4.74% vs 1.57%) and 5 minutes
(2.84% vs 0.67%). With non-thalassemic women as the reference, this
trend was more obvious; whereas the normal fetal group was more likely
to be diagnosed with postpartum hemorrhage. Combining fetal HbH disease
and gestational age reflected medium accuracy in Apgar predictions.
Conclusions: Fetal HbH disease was associated with a higher risk of low
Apgar scores. Thalassemic women with normal fetuses may also have an
increased risk of postpartum hemorrhage, and should be monitored
accordingly. Funding: The Key Research and Development Programs of
Nanning, China (No. 20183038 and No. 20193097). Keywords: Fetal
alpha-thalassemia; Low Apgar scores; Postpartum hemorrhage. Tweetable
abstract: This study shows that fetal HbH disease may increase the risk
of low Apgar scores, and that thalassemic women with normal fetuses are
prone to postpartum hemorrhage.
Kaempferol Protects Mice from D-GalN/LPS-induced Acute Liver Failure by Regulating the Autophagy Pathway
Authors: tian yuan , ren feng , xu ling , zhang xiangying
Published: March 2022

Kaempferol, a flavonoid compound, has various biological functions.
Acute liver failure (ALF) is a lethal clinical syndrome with severe
liver function damage. In this study, we explored the mechanisms
underlying the therapeutic effect of kaempferol in ALF. The ALF mouse
model was established using D-galactosamine (D-GalN, 700
mg/kg)/lipopolysaccharide (LPS, 10 μg/kg). Two hours before the
administration of D-GalN/LPS, different group of mice were pretreated
according different doses of kaempferol, 6 hours after injection of
D-GalN/LPS, and then killed. The survival rate, liver function and
inflammatory cytokine levels were assessed. It was determined whether
kaempferol pretreatment protected hepatocytes from ALF induced by
D-GalN/LPS via autophagy pathway in vivo and in vitro. Pretreatment with
a high dose of kaempferol significantly decreased the survival rate and
increased severe liver damage; however, pretreatment with a low dose of
kaempferol showed the opposite effect. Furthermore, pretreatment with a
high dose of kaempferol augment the levels of proinflammatory cytokines
and markers of the MAPK signaling pathway, while pretreatment with a low
dose of kaempferol showed the opposite effect. Additionally,
pretreatment with a high dose of kaempferol decreased autophagy, but
pretreatment with a low dose of kaempferol increased autophagy in vivo
and in vitro. It was also proved that pretreatment with 3-methyadenine
(3- MA) or Atg7 siRNA to inhibit autophagy partially negated the
hepatoprotective effect of kaempferol (5 mg/kg) pretreatment in ALF mice
induced by D-GalN/LPS. Our findings demonstrate that effects of
different doses of kaempferol on D-GalN/LPS-induced ALF is remarkably
different by regulating the autophagy pathway.
Glycated Hemoglobin and Angiographic Severity in Chinese Patients with Coronary Artery Disease: a Retrospective Cohort Study
Authors: Chen Xueying , Yan Yugang , Gao Ronghua , Zhang Shaohui , Gao Zhencai , Chen Anyong , Wang Jianjun , Zhang Shufang , Dai Wen , Li Fen , Ren Tengteng , Yang Guoliang , Liu Lixin
Published: March 2022

Background: Many studies have shown that Glycated hemoglobin (HbA1c) is
associated with Coronary Artery Disease (CAD). HbA1c was independently
related to angiographic severity in Chinese patients with CAD after
adjusting for other covariates. Some traditional cardiovascular drugs
may have an impact on this relationship. Methods: This retrospective
study enrolled a total of 572 CAD patients who underwent their coronary
angiography and had their HbA1c levels measured at the Chinese Hospital.
The complexity of the coronary artery lesions was evaluated using the
Syntax score, and the subjects were divided into 4 inter quartiles
according to HbA1c levels. Covariates included history of traditional
cardiovascular drugs. Results: The average age of selected participants
was 61.00 ± 9.15 years old，and about 54.72% of them was male. Result
of fully-adjusted linear regression showed HbA1c was positively
associated with Syntax score after adjusting confounders (β=1.09,
95%CI: 0.27, 1.91, P=0.0096). By interaction and stratified analyses,
the interactions were observed based on our specification including:
with the medication history of Statins and Angiotensin Receptor Blockers
(ARBs) (P values for interaction <0.05). Conclusions: In this
study, we found a positive correlation between the HbA1c levels and the
SYNTAX score among CAD individuals, and oral Statins and ARBs medication
could affect the correlation. Thus, HbA1c measurement could be used for
the evaluation of the severity and complexity of coronary lesions among
CAD patients.
Evaluation of left atrial function in uremic patients by speckle tracing imaging
Authors: Ye Fu-Yong , Yang Yuwen , Li Xiaofang , Lin Fei , Liang Yin-Ting , Liu Jianhua
Published: March 2022

Objective:This study aimed to explore the value of speckle tracing
imaging (STI) for assessment of left atrial (LA) function in uremic
patients. Methods. One hundred uremic patients were divided into four
groups according to the New York Heart Association (NYHA) criteria.
Thirty healthy participants were enrolled as a control group. LA
functional parameters were determined using conventional
echocardiography. The strain rate (SR) curve of LA wall was prepared
using STI, and SR in different phases of cardiac cycle were obtained.
+Results. The LA maximal volume (LAVmax) increased and LA passive
ejection fraction (LAPEF) decreased. The LA active ejection fraction
(LAAEF) showed an initial increase followed by a decrease (all
p<0.05). The SR of LA lateral wall and interatrial septum
(IAS) in systole (SRs-LA, SRs-IAS) and early diastole (SRe-LA, SRe-IAS)
showed a steady decrease; the SR of LA lateral and IAS in late diastole
(SRa-LA, SRa-IAS) showed an initial increase followed by a decrease.
Compared with control group, the SRs-LA and SRs-IAS decreased in four
groups with uremia (all p<0.05). A positive correlation was
observed between LAPEF and the absolute value of mean peak early
diastolic SR (|mSRe|) (r=0.862, p<0.05), and
between LAAEF and the absolute value of mean peak late diastolic SR
(|mSRa|) (r=0.756, p<0.05). LAVmax showed a
negative correlation with mean peak systolic SR (mSRs) (r=-0.878,
p<0.05). Conclusion. There was a significant correlation
between LA function and LA strain rate in uremic patients. STI can allow
for an objective and accurate evaluation of LA function in uremic
patients.
Natural Resistance to COVID-19: Lessons for COVID-19 Therapy and Vaccine Development
Authors: Esmaeilzadeh Abdolreza , Mohammadzadeh Azita , Safa Salar Hozhabri , Tahmasebi Safa , Raeesi Zahra , Mohammadzadeh Mitra
Published: March 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member
of the Coronaviridae family that causes the novel coronavirus disease
(COVID-19). SARS-CoV-2 is an RNA enveloped virus that firstly emerged in
Wuhan, China, in December 2019 over the 21st century. It is rapidly
spread by human-to-human transmission through droplets or airborne
particles. COVID-19 can be complicated by acute respiratory distress
syndrome (ARDS) and severe pneumonia, depending on ACE2 and Spike
protein (as viral surface protein). It is required a proper defense
mechanism for the body to be healthy in fighting back against infectious
diseases, especially COVID-19. Since there are no wholly approved drugs,
vaccines, or clinical prevention for this disease at the moment, it is
essential to focus on natural resistance systems, which play critical
roles in supporting the immune system defense function against COVID-19.
The severity of COVID-19 is characterized by an increase in acute phase
reactants and pro-inflammatory cytokines; ferritin, tumor necrosis
factor-α (TNF-α), interleukin-6 (IL-6), and IL-1β. Numerous shreds of
evidence propose that immune homeostasis, genetic susceptibility,
dietary interventions, supplementation, and the environment can have an
imperative role in controlling the severity of SARS-CoV-2 infection and
infected patients’ prognosis. In the current study, we proposed a
comprehensive overview of the considerable part of natural resistance in
the COVID-19 forecast, whether it may afford protection to COVID-19. All
in all, multidisciplinary investigations have been done and need to be
done to identify the clinical implications of natural interventions and
natural resistance potential in COVID-19 susceptibility
Breeding driven enrichment of genetic variation for key yield components and grain starch content under drought stress in winter wheat
Authors: Koua Patrice , Oyiga Benedict , Léon Jens , Ballvora Agim
Published: March 2022

Drought is one of the major abiotic stress factors limiting wheat
production worldwide, thus threatening food security. The dissection of
the genetic footprint of drought stress response offers strong
opportunities toward understanding and improving drought tolerance in
wheat. In this study, we investigated the genotypic variability for
drought response among 200 diverse wheat cultivars (genotypes) using
agronomic, developmental, and grain quality traits, and conducted
genome-wide association studies (GWAS) to uncover the genetic
architectures of these important traits. Results indicated significant
effects of genotype, water regime and their interactions for all
agronomic traits. Grain yield was the most drought-responsive trait and
was highly correlated with kernels number per meter square. GWAS
revealed 17 and 20 QTL regions under rainfed and drought conditions,
respectively, and identified one LD block on chromosome 3A and two
others on 5D associated with breeding progress. The major haplotypes of
these LD blocks have been positively selected through breeding and are
associated with higher starch accumulation and grain yield under drought
conditions. Upon validation, the identified QTL regions caring favorable
alleles for high starch and yield will shed light on mechanisms of
tolerance to drought and can be used to develop drought resistant
cultivars.
Wolff-Parkinson-White syndrome associated with coronary sinus diverticulum, the role of 3- dimentional cardiac mapping system
Authors: Paymard Mohammad , Deyell Marc , Chakrabarti Santabhanu , Laksman Zachary , Larsen Jacob , Yeung-Lai-Wah John
Published: March 2022

Posteroseptal accessory pathways located in the CS diverticulum are rare
and unique forms of accessory pathways which are difficult to precisely
locate and ablate. The ablation of this type of accessory pathway could
also be associated with collateral injury to the neighbouring coronary
arteries. We present a case of Wolff–Parkinson–White syndrome due to a
CS diverticulum accessory pathway with previous failed ablation attempt
who was safely and successfully ablated. We demonstrated that using the
advanced 3-D cardiac mapping system could guide clinicians to precisely
locate and safely ablate these difficult pathways.
Potential cytochrome P450–mediated drug-drug interactions with selective serotonin reuptake inhibitors: A retrospective analysis of a university hospital prescription database
Authors: Ozbey Gul , Yardımsever Mehmet , ÖZ Pelin Rezzan , TAŞ Hazal
Published: March 2022

Rationale, aims and objectives The study aimed to investigate the rate
of the potential cytochrome P450 (CYP450)-mediated drug-drug
interactions (DDIs) between selective serotonin reuptake inhibitors
(SSRI) and other drugs, and identify the most common CYP450-interacted
SSRI-drug combinations in real-life clinical practice. Methods This is a
retrospective analysis of SSRI prescribing data from the Akdeniz
University Hospital database, a tertiary hospital database in Turkey.
Prescriptions which were included an SSRI had been selected (from
January 2014 to December 2018). Lexicomp® Online™ was used to identify
potential CYP450-mediated DDIs. Results A total of 7.5% of SSRI
prescriptions were at risk of potential CYP450-mediated DDIs; 74.4% (n
= 67) of the pDDIs were identified as category D modification of
treatment should be considered. Antipsychotics were involved in 71.8%
category D potential DDIs and 83.6% category C potential DDIs. The
medications most frequently identified in combination with SSRIs were
risperidone (31.7%) and aripiprazole (31.6%). Finally, CYP2D6 and
CYP3A4 were the two most commonly affected CYP450 isozymes. Conclusions
Prescribing antipsychotic-SSRI pairs interacting via CYP450 may increase
serum concentrations of antipsychotics. Using DDI alert software while
writing electronic prescriptions during clinical practice may reduce the
frequency of ADRs.
Predictive ranges for the population of CD4 + lymphocytes for HIV positive patients on antiretroviral treatment
Authors: Rodríguez Javier , Pérez Carlos , Soracipa Ribká
Published: March 2022

Introduction: part of the effectiveness of follow-ups of patients with
HIV in antiretroviral therapy is done through the quantification of CD4
+ lymphocytes, hence the correct establishment of these values is an
issue of interest in the clinical setting. Objective: to establish
predictive mathematical relationships between CD4+ cell counts in ranges
>500, [200,500], <200, between 200 and
>500 and <200 up to 500 cells/μL3 with the
absolute leukocyte count of patient samples over time in the context of
the theory of probability. Methods: Through an inductive process carried
out in 11 patient samples, mathematical patterns that forecast in time
the correspondence between absolute leukocyte counts and CD4+ counts
that can occur in five ranges of clinical interest. Then, a confirmation
was done with 139 patients in a blind study obtaining the probability
values for each range as well as sensitivity and specificity. Results:
The five dynamics predicted achieved probabilities that varied between
0.96 and 1, with a global probability of 0.99 with sensitivity and
specificity values of 99%. Conclusions: a self-organized mathematical
temporal order that allows to forecast the values of CD4+ cells in
relation to leukocyte counts in ranges of clinical interests was found,
which could be useful to develop surveillance programs of HIV-infected
patients in low-income countries, improving their survival rates.
BLINATUMOMAB AS A SUCCESSFUL AND SAFE THERAPY IN A DOWN SYNDROME PATIENT WITH RELAPSED/REFRACTORY B-PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA: CASE REPORTS AND LITERATURE. REVIEW
Authors: SORA' Federica , annunziata mario , laurenti luca , giammarco sabrina , chiusolo patrizia , innocenti idanna , autore francesco , metafuni elisabetta , galli eugenio , bacigalupo andrea , ferrara felicetto , Sica Simona
Published: March 2022

Down syndrome (DS) is one of the most common chromosomal disorders and
the children with are at a 20-fold increased risk for acute
lymphoblastic leukemia (DS-ALL). These patients also face lower survival
rates due to unique biological features of the leukemic blasts and
substantially increased therapy related mortality. Blinatumomab has been
shown to be safe and effective having excellent results and in patients
with relapsed/refractory (R/R) BP-ALL. We report here use of
blinatumomab, a bispecific T-cell engager antibody construct, in 3
patient with DS and relapsed/refractory BP-ALL . ALL patient had no
significant toxicity and achieved remission after only one cycle of
blinatumomab .
Genomic identification of the emerging multidrug-resistant Salmonella Virchow monophasic variant causing septic arthritis of the knee joint
Authors: Wang Zhenyu , Xu Haiyan , Chu Chao , Tang Yuanyue , Li Qiuchun , Jiao Xinan
Published: March 2022

In this study, a 4-year-old girl presented with a case of septic
arthritis and fever. Salmonella was isolated from her knee effusion and
feces; isolates were confirmed to be a novel S. Virchow monophasic
variant (Salmonella 6,7,14:r:-) based on core genome MLST (cgMLST),
CRISPR typing combined with analysis of the fljAB operon. Whole-genome
sequencing analysis revealed that replacement of the fljAB operon by a
4.8 kb cassette from E. coli caused the nonexpression of phase-2
flagellar antigen in S. Virchow monophasic variant. Additionally, the
acquisition of Salmonella genomic island 2 (SGI2) with an antimicrobial
resistance gene cassette enabled the isolates to be multidrug-resistant
(MDR) to chloramphenicol, tetracycline, trimethoprim, and
sulfamethoxazole. The emerging of MDR S. Virchow monophasic variant
causing human infection should be concerned in the national Salmonella
surveillance system.
Virtual Colorectal Clinics: Can patient electronic care records and straight to test reduce delay in patient diagnosis and treatment?
Authors: Wilson Rebekah , Johnston Dorothy , McKay Damian , Mark David
Published: March 2022

Background: Straight to test (STT) is a recognised pathway for improving
the two week waiting time targets for red flag referrals.2,4-6 However
STT relies on Telephone Assessment Clinics (TAC) by clinicians or
specialist nurse practitioners when determining suitability of referred
patients for investigations.4-7 Electronic patient care records (ECR)
provide clinicians with a greater volume of clinical information
allowing virtual triage and STT with a reduced dependence on TAC
therefore improving waiting time for tests and treatment. Methods: A
retrospective review of 300 colorectal referrals was performed. Patients
awaiting an appointment were reviewed electronically, using ECR, by a
single colorectal surgeon and re-triaged STT if appropriate. The delay
in time from the referral to initial review was removed to create a
second group for statistical comparison to demonstrate time saved if the
strategy was adopted at point of original triage. Data was analyzed
using SPSS. Results: 300 colorectal referrals were reviewed between
February 5th 2018 and July 22nd 2019. 91.3% (n= 274) were red flag, 7%
(n= 21) urgent and 1.7% (n=5) routine. 94% (n=282) were sent straight
to test. Red flag patients processed via traditional referral and clinic
had a median time to scope of 36 days (IQR = 55 days) compared with 22.5
days (IQR = 19.75 days), p < 0.001 if triaged straight to test
via virtual clinic. Median time to management for red flag patients was
59 days (IQR = 63.5 days) for traditional and 35 days (IQR 51.5 days)
for STT, p < 0.001. 71.7% of patients (n=215) required no
follow up clinic appointment. Conclusion: Straight to test using ECR is
a safe and effective means of triage and is a useful tool when
incorporating STT access for colorectal referrals in order to reduce
waiting times for tests and treatments.
Ewing sarcoma of the 9th rib subsequent to pediatric leukemia: a case series
Authors: Vandenheuvel Julia , Elliott Leighton , Zinn Daniel , Miller Michal Ann , Troutman Jacob
Published: March 2022

Ewing sarcoma is an aggressive malignancy of bone and soft tissue that
accounts for approximately 2% of cases of childhood cancer. It has been
rarely reported as a secondary neoplasm. Data from the Childhood Cancer
Survivor Study has evaluated secondary sarcomas in 5-year survivors of
childhood cancer. We report two pediatric patients in northeast
Pennsylvania, who developed secondary Ewing Sarcoma of the 9th rib
within 5 years of primary childhood leukemia diagnoses.
Erratum on “Certain family of fractional wavelet transforms
Authors: Verma Amit , Gupta Bivek
Published: March 2022

In this errata sheet, we comment on the definition of the kernel of the
continuous fractional wavelet transform (CFrWT) studied in the article
“A certain family of fractional wavelet transformations” by
Srivastava, Khatterwani and Upadhyay [Mathematical Methods in the
Applied Sciences, Vol 42, No. 9, 3103–3122, 2019]. We have modified
the definition of the kernel so that results obtained in the paper are
true for all non zero values of the dilation parameter.
Severe acute respiratory distress syndrome in COVID-19 and Is oxygen therapy essential ?
Authors: Bawaskar himmatrao , Bawaskar Pramodini
Published: March 2022

Morbidity and mortality due to COVID-19 is due to0 severe acute
respiratory distress syndrome(SARDS). Majority of victims dies on way to
hospital or in ambulance for want of oxygen and ventilator bed. Here we
report A case recovered without oxygen irrespective of oxygen saturation
74%.
Values of new-onset right bundle branch block in patients receiving transcatheter aortic valve replacement
Authors: Wang Dongjuan , Li Hengdong , Ye Honghua , Jiang Longfu
Published: March 2022

Transcatheter aortic valve replacement (TAVR) is a revolutionized
treatment for severe aortic valve stenosis. Although new and improved
TAVR devices are constantly being developed, cardiac conduction
abnormalities post-TAVR requiring permanent pacemaker implantation
(PPMI) still occur frequently. Previously, pre-existing right bundle
branch block (RBBB) has been shown to be predictive of PPMI after TAVR,
while occurrence of new left bundle branch block (LBBB) was associated
with a higher rate of PPMI. However, less attention has been paid to the
clinical values of new-onset RBBB post-TAVR. To our knowledge, this is
the first report focus on the association of new-onset RBBB and PPMI
after TAVR. Sometimes only changes in the right bundle branch can be
detected, but the patient may have co-existing severe conduction block
at this time, which caused adverse events including Adams-Stokes
syndrome. New-onset RBBB post-TAVR may also have important clinical
implications.
Corrigendum on: Munkholt Christensen, Maria (2021), “Meditatio mortis. Meditating on death, philosophy and gender in late antique hagioraphy”, Philosophy and Society 32(2): 177-193, doi: https://doi.org/10.2298/FID2102177M.
Authors: Editorial E
Published: March 2022

The author of the article: Munkholt Christensen, Maria (2021), ?Meditatio
mor?tis. Meditating on Death, Philosophy and Gender in Late Antique
Hagioraphy?, Philosophy and Society 32 (2): 177-193 has informed the
Editorial Office of an error in the title of the article. The correct title
of the article is: ?Meditatio mor?tis. Meditating on Death, Philosophy and
Gender in Late Antique Hagiography?. The author has requested for this error
to be corrected. Therefore, the journal is publishing this Corrigendum.

 Link to the corrected article 10.2298/FID2102177M
Tribotechnical properties of experimental hard alloys with modified cobalt binder
Authors: Fominov E. V. , Shuchev C. G. , Aliev M. M.
Published: March 2022

Introduction. This paper discusses tribomechanical characteristics of experimental hard alloys with a modified cobalt binder under friction without lubrication on hard-to-cut materials – stainless steel and titanium alloy. The research objective is to evaluate the process of friction interaction for each friction pair according to a number of parameters, and to determine the optimal combinations of “experimental hard alloy – structural material” on the basis of the established tribological indicators.

Materials and Methods. Tribological tests of hard alloys were carried out using a cylinder-to-disc friction scheme for different sliding speeds and temperatures under constant load without the use of lubricants. Comparison of the friction interaction process was carried out by the frictional force, volumetric wear and roughness of the friction tracks on the counterbody. Stainless steel 12H18N9Т and titanium alloy ВТ3-1 were used as counterbody materials. The resistance of experimental compositions to the abrasive type of wear was determined through measuring the surface dynamic microhardness on a scanning nanohardness tester by analyzing the thickness of the scratches caused by the indenter.

Results. According to the results of surface microindentation, the experimental alloys 2.22 (binder 5.65% Co + l.8% Mo + 0.6% Ti) and 2.23 (binder 5.1% Co + 2.7% Mo + 0.61 % Ti) are characterized by the highest microhardness. For these materials, the average scratch width at various forces was minimal. During tribological tests, the best frictional characteristics were recorded for stainless steel in combination with experimental alloy 2.22, and for the friction pair “titanium alloy VT3-1 — hard alloy 2.23”. The friction of this combination of materials was characterized by low friction coefficients with a low level of fluctuations, minimal wear of samples, and changes in the initial microrelief of their surfaces.

Discussion and Conclusions. As a result of the research, the optimal friction pairs from the point of view of tribological interaction were established, specifically “titanium alloy VT3-1 — hard alloy 2.23” and “stainless steel 12X18N9T – hard alloy 2.22”. The frictional interaction for these combinations of materials is characterized by minimal volumetric wear, which will contribute to increasing the wear resistance of the tool in the areas of elastic contact on the front and rear surfaces.
A social work study of effective cultural, social economic factors on work stress: A Review
Authors: Iravani Mohammad Reza , ShekarchiZade Ahmad Reza
Published: March 2022

Correlation between external factor and internal responses of the body, other studies had been done by Wolf and Wolf show that different patients suffer changes in the stomach activity, for example in some patients, changes in excitement situation is accompanying with the change in the scientific study about blood circulation and stomach discharges. Methodology: Next years, the main point of this of the study was developed and the field of scientific study in medical researches was provided and led to the subject psyche, body disorders like ulcer and asthma. Results: We collect information Statistics show affected of current behavioral and emotional reactions with number and digit and costs of Work stress is very high and determining the precise level is difficult. Conclusion: All of us experienced such relation among external factors and internal responses like when we concerned or when we are anxiety we fell muddle.
Study the Effects of Teaching Cognitive and Metacognitive Strategies on Enhancement of the Academic Performance of Sama Vocational Schools Probation Students of Najaf Abad Branches in School Year 2013-2014
Authors: Hojati Mahbobe , Rezaei Fatemeh , Iravani Mohammadreza
Published: March 2022

This study examined the effects of teaching cognitive and metacognitive strategies on the enhancement of the academic performance of Sama vocational schools probation students of Najaf Abad branches in the school year 2013-2014. Methodology: Semi-experimental method with pre-test and post-test study with a control group of 200 probation students in the first academic semester girls and boys, of whom 50 patients samples were randomly selected. Results: With a random assignment to experimental and control groups (n = 25 for each group) were divided. Conclusion: Data using analysis of covariance showed that cognitive and metacognitive strategies training have a positive effect on academic performance.