bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessing hydrological and water quality parameters in the Hathmati Watershed using the SWAT (Soil and Water Assessment Tool)
Authors: Shah Payal Vinitkumar , Shaikh Mohd Zuned M. , Lodha Pradeep P.
Published: October 2023

The study is conducted on the Hathmati River, which is the principal tributary of the Sabarmati River, one of Gujarat's biggest rivers. Indicators of water quality such organic N, organic P, NO3, NH4, NO2, total N, and total P were compared between the observed values in the watershed and the streamflow models. For monthly streamflow and monthly nitrate during the calibration period of 1999–2012, and for 0.87 and 0.56 for the validation period of 2013–2020, respectively, the Nash–Sutcliffe efficiency was 0.89 and 0.79. The measured water quality data at three locations in the watershed were largely compatible with their corresponding modeled values, while the agreement varied by nutrients. Using the parameters used to forecast the hydrological and water quality responses in the watershed region, the Soil and Water Assessment Tool model faithfully duplicated the hydrological and water quality conditions in this agricultural watershed. The results of the modeling indicated that nutrients are one of the key determinants with regard to the quality of the water, in accordance with the current land use and management practices in the watershed. Management practices should be implemented in order to reduce the nutrient load and meet the watershed's requisite water quality standards.
Functional Insight into hTRIR
Authors: Xie Jumin , Mao Hui
Published: October 2023

:

The uncharacterized C19orf43 was discovered to be associated with hTR
maturation. Our previous work indicated that C19orf43 cleaves distinct RNA types but
not DNA. We then named it hTR-interacting RNase (hTRIR) (Uniprot: Q9BQ61).
hTRIR works in a broad range of temperatures and pH without any divalent cations
needed. hTRIR cleaves RNA at all four nucleotide sites but preferentially at purines. In
addition, hTRIR digested both ends of methylated small RNA, which suggested that it
was a putative ribonuclease. Later, we designed more nucleotides that methylated
small RNA to determine whether it was an exo- and/or endoribonuclease. Unlike
RNase A, hTRIR could digest both ends of methylated RNA oligos 5R5, which
suggested it was potentially an endoribonuclease.
Development of Computational Correlations among Known Drug Scaffolds and their Target-Specific Non-Coding RNA Scaffolds of Alzheimer's Disease
Authors: Roy Debjani , Kundu Shymodip , Mukherjee Swayambhik
Published: October 2023

Background:

Alzheimer's disease is the most common neurodegenerative disorder. Recent
development in sciences has also identified the pivotal role of microRNAs (miRNAs) in AD
pathogenesis.

Objectives:

We proposed a novel method to identify AD pathway-specific statistically significant
miRNAs from the targets of known AD drugs. Moreover, microRNA scaffolds and corresponding
drug scaffolds of different pathways were also discovered.

Material and Methods:

A Wilcoxon signed-rank test was performed to identify pathway-specific
significant miRNAs. We generated feed-forward loop regulations of microRNA-TF-gene-based
networks, studied the minimum free energy structures of pre-microRNA sequences, and clustered
those microRNAs with their corresponding structural motifs of robust transcription factors. Conservation
analyses of significant microRNAs were done, and the phylogenetic trees were constructed.
We identified 3’UTR binding sites and chromosome locations of these significant microRNAs.

Results:

In this study, hsa-miR-4261, hsa-miR-153-5p, hsa-miR-6766, and hsa-miR-4319 were
identified as key miRNAs for the ACHE pathway and hsa-miR-326, hsa-miR-6133, hsa-miR-4251,
hsa-miR-3148, hsa-miR-10527-5p, hsa-miR-527, and hsa-miR-518a were identified as regulatory
miRNAs for the NMDA pathway. These miRNAs were regulated by several AD-specific TFs,
namely RAD21, FOXA1, and ESR1. It has been observed that anisole and adamantane are important
chemical scaffolds to regulate these significant miRNAs.

Conclusion:

This is the first study that developed a detailed correlation between known AD drug
scaffolds and their AD target-specific miRNA scaffolds. This study identified chromosomal locations
of microRNAs and corresponding structural scaffolds of transcription factors that may be responsible
for miRNA co-regulation for Alzheimer's disease. Our study provides hope for therapeutic
improvements in the existing microRNAs by regulating pathways and targets.
Phytochemicals Showing Antiangiogenic Effect in Pre-clinical Models and
their Potential as an Alternative to Existing Therapeutics
Authors: Senrung Anna , Tripathi Tanya , Aggarwal Nikita , Janjua Divya , Yadav Joni , Chaudhary Apoorva , Chhokar Arun , Joshi Udit , Bharti Alok Chandra
Published: October 2023

Angiogenesis, the formation of new blood vessels from a pre-existing vascular network, is an important hallmark of several pathological conditions, such as tumor growth and metastasis, proliferative retinopathies, including proliferative diabetic retinopathy and retinopathy of
prematurity, age-related macular degeneration, rheumatoid arthritis, psoriasis, and endometriosis.
Putting a halt to pathology-driven angiogenesis is considered an important therapeutic strategy to
slow down or reduce the severity of pathological disorders. Considering the attrition rate of synthetic antiangiogenic compounds from the lab to reaching the market due to severe side effects,
several compounds of natural origin are being explored for their antiangiogenic properties. Employing pre-clinical models for the evaluation of novel antiangiogenic compounds is a promising
strategy for rapid screening of antiangiogenic compounds. These studies use a spectrum of angiogenic model systems that include HUVEC two-dimensional culture, nude mice, chick chorioallantoic membrane, transgenic zebrafish, and dorsal aorta from rats and chicks, depending upon available resources. The present article emphasizes the antiangiogenic activity of the phytochemicals
shown to exhibit antiangiogenic behavior in these well-defined existing angiogenic models and
highlights key molecular targets. Different models help to get a quick understanding of the efficacy and therapeutics mechanism of emerging lead molecules. The inherent variability in assays and
corresponding different phytochemicals tested in each study prevent their immediate utilization in
clinical studies. This review will discuss phytochemicals discovered using suitable preclinical antiangiogenic models, along with a special mention of leads that have entered clinical evaluation.
Chemical Composition, In vitro and In silico Evaluation of Essential Oil Extracted from Mentha Piperita L. for Lung Cancer
Authors: Singh Bhim , Kumar Amit , Prajapati Kumari Sunita , Patel Shivam , Kumar Shashank , Jaitak Vikas
Published: October 2023

Background:

Mentha piperita, a naturally occurring herb, is utilized in medicinal formulations. It possesses abundant bioactive elements, including flavonoids and phenolic acid
compounds,that exhibit various properties such as antioxidants, anti-inflammatory and anti-cancer.

Objective:

In the present study, chemical constituents of essential oil extracted from Mentha piperita
were analyzed and identified through GC-MS. In vitro antiproliferative activity was performed on
A549 lung cancer cell line lines. In silico study was conducted by Schrodinger’s Maestro’s software
to identify chemical constituents in the plant as potential EGFR (Epidermal Growth Factor Receptors) inhibitors

Methods:

Hydro-distilled essential oil was analyzed by GC-MS to identify chemical components
based on the retention index and mass fragmentation pattern, which was then tested for its antiproliferative activity by MTT assay against human lung cancer cell lines. All the identified constituents
were investigated in silico for their affinity towards EGFR (Epidermal Growth Factor Receptors).

Results:

A total of thirty constituents were identified where D-carvone (56.69%), L-limonene
(12.36%), squalene (3.36%), cis-carveol (2.93%), and α-amorphene (2.36%) were observed as major
constituents of the essential oil. The essential mentha oil also exhibited antiproliferative activity
against lung cancer cell lines with an IC50 value of 86.05 µg/ml. Furthermore, from the in silico
study, five constituents were identified to have a better affinity for EGFR (Epidermal Growth Factor
Receptors) than that of the standard drug Osimertinib.

Conclusion:

In the present study, the aerial part of the plant Mentha piperita was hydrodistilled.Thirty phytoconstituents were identified through GC-MS data. An in-silico study was performed using
Schrodinger software, and a further in vitro study was performed in which essential oil showedgood
antiproliferative activity against the A549 cancer cell line.
Uncovering the Biological Applications of Cinnamic Acid Derivatives: A Patent Review
Authors: Porto Ricardo Silva , Porto Viviane Amaral
Published: October 2023

Background:

Cinnamic acid, derived from Cinnamomum cassia, is a natural compound
known for its wide-ranging therapeutic properties and minimal toxicity. Extensive research has
demonstrated the diverse biological activities displayed by cinnamic acid derivatives, encompassing
their potential as agents against cancer, diabetes, microbial infections, tuberculosis, malaria, and
more.

Objective:

This review aims to provide an overview of the latest applications detailing the biological
activity of cinnamic acid derivatives, as documented in patents.

Methods:

The published patent data underwent a prior screening and selection process based on their
relevance and primary focus: the biological activities of cinnamic acid derivatives as potential drugs.
Espacenet, USPTO, and Google Patents were used for this selection.

Results:

Cinnamic acid derivatives demonstrate a range of activities, including anticancer, antibacterial, anti-inflammatory, analgesic, anticholinesterase, and other properties. These biological activities
were investigated across different derivatives, emphasizing their pharmacological potential when
compared to reference compounds.

Conclusions:

Despite several patents have explored the biological properties of cinnamic acid derivatives, there has been a lack of a comprehensive review dedicated to this subject. Accordingly, this
review aims to facilitate the discovery of new and diverse potential drugs with various therapeutic
profiles.
A Review on Novel Nanofiber-based Dermal Applications: Utilization of Polysaccharides
Authors: Rathnasinghe Nimasha , Kaushani K.G. , Jayasinghe R.A. , Nilmini A.H.L.R. , Tissera Nadeeka D. , Wijesena Ruchira N. , Priyadarshana Gayan
Published: October 2023

Nanotechnology is a rapidly expanding field of study because of its numerous dermal applications and benefits in dermal care. It also represents progress in research and development by enhancing product efficacy through the adoption of novel technologies. Nanotechnology is increasingly being used in dermal applications to avoid some of the problems associated with traditional treatments. Dermal applications are the segment of the consumer products market that is expanding the fastest, and their popularity has exploded in recent years. In addition to wrinkles, hyperpigmentation, photoaging, hair damage, and dandruff, nanofibers are now frequently used in dermal treatments for skincare, hair, lips, and nails. These innovative dermal applications using nanofibers provide improved skin penetration, higher stability, site-specific targeting, controlled and prolonged drug release, and high entrapment effectiveness. The outcome of dermal applications can be improved with nanofibers by modifying their structure, functionality, chemical and mechanical resistance, and additional attributes. The importance of biopolymers in processing nanofibers, nanofiber processing methods, an overview of dermal applications' significance, and dermal applications based on nanofibers will all be discussed in this review.
Nature’s Signature in Ayurveda with an Ethnopharmacological Approach:
A Narrative Review
Authors: Balkrishna Acharya , Mishra Shalini , Mishra Rajesh Kumar , Rana Maneesha , Singh Shalini , Arya Vedpriya
Published: October 2023

:

The nature's signature in Āyurveda i.e. Doctrine of Signatures (DOS), which calls for
utilizing natural substances that resemble a particular body part or organ, is consistent with the
ethnopharmacological practice of choosing therapeutic plants based on their visible physical
qualities. In order to promote health and treat ailments, the ancient Indian medical system known
as Āyurveda employs natural ingredients including plants, minerals, and animal products. The
study of conventional medicine and the application of natural products for therapeutic reasons
are known as ethno-pharmacology. This review explores various research on ayurvedic herbs,
their doctrinal signature, and the status of our understanding of ethno-pharmacology. However, by integrating Āyurveda plants' doctrinal signatures with ethnopharmacological methods,
it might be better to comprehend the therapeutic potential of plants and create novel treatments
for a range of ailments. Combining these two perspectives might assist in understanding how
nature may heal and how natural medicines could improve health and wellness. It was believed
that a plant containing parts that resembled portions of human bodies, animals, or other items
had practical use for those parts, animals, or objects. This philosophy was shown in some of the
Indian medicinal plants that are discussed in this article.
Preparation and Properties of Biocomposite Prepared from Waste
Polystyrene and Prospopis africana Biochar
Authors: Adeniyi Adewale George , Abdulkareem Sulyman A. , Iwuozor Kingsley O. , Emenike Ebuka Chizitere , Adeyanju Comfort A. , Abdulkareem Maryam T. , Omisore Maroof O.
Published: October 2023

Introduction:

In this study, the pods of Prospopis Africana were thermochemically
converted into biochar and combined with polystyrene resin in varying
proportions to form composites.

Method:

The composites were then characterized to determine their characteristics
using Fourier transform infrared spectroscopy (FTIR), a Scanning electron microscope
coupled with the energy dispersive X-ray Spectrophotometer (SEM-EDX), and a Differential
scanning calorimeter (DSC).

Result:

The FTIR analysis confirmed the changing or shifting of several peaks in the
polystyrene resin and biochar samples. The hardness test showed that incorporating
the Prosopis africana biochar into the solvated polystyrene matrix reduced the latter's
hardness and reduced the impact value. SEM analysis showed that the biochar was
firmly embedded in the polystyrene matrix, showing good adhesion between the matrix
and the filler.

Conclusion:

This study has demonstrated that composites produced from Prosopis
africana biochar filler and polystyrene resin matrix could be used as adsorbents and in
the fabrication of materials requiring good electrical and thermal properties.
Empowering Consumers: The Evolving Paradigm of Customization in
Personal Care Products
Authors: Bhosale Uday , Gaddam Sridevi , Koutam Harish , Sapre Prajkta , Nallan Chaitanya , Syed Shoaeb M
Published: October 2023

Personal care products available in the market are typically designed for the general
population, assuming they will be suitable for the majority of consumers. However, customization
challenges this notion by focusing on developing products tailored to individual needs, preferences,
and unique factors, such as seasonal variations and geographical demands. It acknowledges
that people may respond diversely to the same product.

:

Customization in personal care products entails the ability to tailor products to an individual's
specific requirements, such as their skin type, hair type, fragrance preferences, etc. Other preferences
include geographical requirements like climate, UV exposure, and cultural preferences,
along with seasonal changes like winter, monsoon, summer, spring, and fall. The entire experience,
including packaging, is personalized.

:

Currently, personal care products represent a relatively small portion, accounting for approximately
10-15% of the overall market, with non-customized products comprising 85-90%. However,
recent data suggests that customization is growing at an annual rate of 15.3%, and it is
projected to surpass non-customized products by 2031.

:

Customization offers several advantages, including a better fit for consumers' physical and mental
health, targeted solutions for specific issues, and increased efficacy. Leading brands in customized
personal care products have span different regions worldwide. For instance, SkinCeuticals,
an American brand, offers customized skincare products tailored to address individual skin concerns
and needs.

:

In India, Vedix and SkinKraft from IncNut Life Style are pioneering brands that provide customized
personal care products based on an individual's skin and hair type, along with a Prakriti
analysis. These brands offer direct-to-consumer services and are headquartered in Hyderabad,
India.

:

The demand for customized personal care products is rapidly increasing worldwide. Beyond individual
needs and preferences, further development is required to cater to seasonal and geographical
requirements, enabling the creation of more effective products.
Storage Options with Amazon EC2 Instance
Authors: Dubey Parul , Kumar Tiwari Arvind , Raja Rohit
Published: October 2023

This chapter provides an overview of the storage options available with EC2
instances, namely EC2 Instance storage, EBS, EFS, and Amazon S3. It focuses on
illustrating the creation of EBS volumes and attaching them to EC2 instances. The
chapter highlights the unique features and uses cases of each storage option,
empowering readers to make informed decisions based on their needs. By following the
step-by-step instructions, readers gain practical guidance on configuring and utilizing
EBS storage effectively within the EC2 environment. Overall, this chapter serves as a
valuable guide for optimizing storage configurations and maximizing the benefits of
EC2 instances in AWS.
Cloud Integrations
Authors: Dubey Parul , Kumar Tiwari Arvind , Raja Rohit
Published: October 2023

This chapter delves into the application integration services offered by
AWS, which proves particularly beneficial for microservices, distributed systems, and
serverless applications. These services facilitate seamless communication between
loosely related components. The chapter provides an overview of various AWS
integration services, emphasizing their importance in integration processes. Key topics
covered in this chapter include SQS (Simple Queue Service), SNS (Simple Notification
Service), Kinesis, Pinpoint, and Amazon MQ. Furthermore, the chapter offers practical
guidance through hands-on illustrations focused on SQS, allowing readers to gain
valuable experience in utilizing these services. By exploring these AWS application
integration services, readers can enhance the efficiency and effectiveness of their
integration processes. This chapter serves as a comprehensive guide for understanding
and utilizing services like SQS, SNS, Kinesis, Pinpoint, and Amazon MQ, enabling
seamless communication and integration within AWS environments.
ДИНАМІКА РАДІОГЕННИХ ЗМІН ВМІСТУ РЕТИНОЛУ В КРОВІ ЗА РІЗНИХ РЕЖИМІВ ОПРОМІНЕННЯ ТВАРИН
Authors: Петрина Любомира , Мойсеєнко Микола , Писклинець Уляна , Петрина Дмитро , Петрина Марія
Published: October 2023

Експериментальні дослідження проводили на щурах-самцях лінії Вістар. Одноразове опромінення тварин в дозах 1.0, 5.0 та 9.0 Гр проводили від джерела 60Со з потужностями доз 0.001, 0.01, 0.1 та 1.0 Гр/хв. Вміст ретинолу визначали через 0.5, І, 2, 4, 6, 8, 10, 15, 20 та 30 діб після впливу. Встановлено, що вміст вітаміну А в сироватці крові змінювався хвилеподібно, що свідчить про різну чутливість вітаміну А до дії опромінення в дозах 1.0, 5,0 та 9.0 Гр, залежно від її потужності, та про тривалість збереження цих параметрів після впливу. Відносна зміна вмісту ретинолу на одиницю поглинутої дози в сироватці крові опромінених тварин зростала прямо пропорційно потужності дози через 12 та 24 год після впливу радіації. Відносне зниження вітаміну А обернено пропорційно залежало від потужності дози радіації через 8 та 10 діб після експозиції. У тварин, опромінених за потужностей доз 0,001 та 0,01 Гр/хв, на 6, 8, 10 та 30 добу не відзначено різниці у відносній зміні вмісту РН на одиницю поглинутої дози.
Clinical and Morphological Parallels in the Etiopathogenesis of Secretory Otitis Media
Authors: Popovych Vasyl , Orishchak Ostap
Published: October 2023

Introduction. According to global statistics, secretory otitis media (SOM) ranks first among middle ear infections. This pathology is believed to be characteristic of the pediatric population; however, recent global statistics indicate an increase in the percentage of SOM cases among the adult population. Information about adult-onset SOM varies, with no consensus on the causes of its occurrence. Diverse clinical presentation of the condition, often unsatisfactory treatment outcomes, and a high percentage of recurrences have necessitated a more in-depth study of the etiological factors associated with adult-onset SOM.

The objective of the research was to determine clinical and morphological parallels in the etiopathogenesis of adult-onset SOM as well as to establish the relationship between the clinical, otoscopic, and endoscopic presentations and pathomorphological changes in the tubal tonsils in these patients.

Materials and Methods. Sixty-eight (38 men and 30 women) patients with SOM at the age of 18 to 65 years were examined. Fifty-three patients were diagnosed with unilateral pathological process, while in 15 individuals, bilateral SOM was observed. All the patients underwent a comprehensive assessment of their complaints, collection of their medical history, and a full ear, nose, and throat examination using conventional methods, optical techniques, video endoscopy of the nasopharynx and tubal tonsils, and otomicroscopy. In 15 patients, to exclude a malignant process, tissue samples from the tubal tonsils were taken for pathological examination.

Results. One of the causes of adult-onset SOM could be pathomorphological changes in the tubal tonsils, specifically their inflammation, hypertrophy, and in some cases, tumours. The clinical course and stages of SOM development depend on the duration of auditory tube obstruction. Inflammation of the tubal tonsils usually results in catarrhal and serous SOM, while hypertrophy or hyperplasia of the tubal tonsils is observed in patients with mucous SOM.

Conclusions. Pathomorphological changes in the tubal tonsils have been established as one of the reasons for developing SOM in adults. Both the clinical presentation of SOM and the stage of its progression depends on the type of pathomorphological changes, their localization (upper or lower pole), and the duration of auditory tube obstruction. A prolonged, recurrent, and treatment-resistant course of SOM may be associated with hypertrophy of the tubal tonsil or tumours. Clinical and morphological parallels identified by us will enable timely utilization of effective etiopathogenetic treatment of SOM and prevent the occurrence of complications.
Influence of Medicinal Plants Extracts from the Flora of Ukraine on the Growth of Cultures of Candida Yeast Fungi Selected from Dental Patients
Authors: Ohiienko Tetiana
Published: October 2023

Antimycotics, which are widely used in this case, increasingly do not give the desired effect, since various types of Candida fungi are constantly modified forming resistant strains. This necessitates the search for new antifungal medication to affect them. From this point of view, medicinal plants are interesting for the research. They contain a number of biologically active compounds including substances that have antifungal properties against yeast-like fungi.

The aim. The objective of our research was to study in an experiment the influence of medicinal plants extracts of the flora of Ukraine on the growth of cultures of Candida various species associated with dental pathology.

Materials and methods. We selected 15 aqueous-ethanol extracts for further research which showed significant antifungal activity against C. albicans, C. tropicalis, C.lusitaniae, C.kefyr і C. lipolytica.on the basis of the initial screening of the antifungal properties of various medicinal plants of the flora of Ukraine.

Results. According to the results of the work performed, 15 extracts were selected for further study by a more accurate method of serial dilutions in order to establish their fungicidal/fungistatic concentrations. The results of the testing showed that all 16 studied extracts in the dilution range from 1:20 to 1:640 showed at least a fungistatic effect against most strains of Candida fungi associated with dental pathological processes.

Conclusions. The obtained research results indicate a significant prospect of using plant extracts and medication based on them for oral thrush treatment.
El capital intelectual en el sector de confección textil. Un estudio explicativo de la rentabilidad
Authors:   Universidad Técnica de Ambato, Gómez Romo María del Carmen , Totoy Sinalin Erika Vanessa ,   Universidad Técnica de Ambato, López Gómez Andrés Francisco ,   Instituto Superior Tecnológico España
Published: October 2023

Introducción: el conocimiento es reconocido como un factor primordial en la nueva era de la economía del conocimiento, y el capital intelectual como el principal derivador de valor. Objetivo: determinar la influencia del capital intelectual en la rentabilidad económica, y financiera de las empresas del sector de confección textil del Ecuador en el período 2014 - 2019. Metodología: se utilizó el Modelo del Coeficiente Intelectual de Valor Añadido (VAIC). Se construyó una base de datos a partir de la depuración de 1800 estados financieros de acuerdo con los requisitos metodológicos. Se aplicó un análisis descriptivo y correlacional para identificar la evolución y asociación de las variables; con la regresión múltiple se estableció la influencia del VAIC y las variables de control en la rentabilidad. Resultados: El 29,6 % de la rentabilidad sobre activos y el 38,8 % de la rentabilidad sobre el patrimonio, respectivamente son explicadas por el VAIC y las variables de control, que corresponden al tamaño de las empresas y la razón de endeudamiento. Conclusiones: El capital intelectual incide positivamente en indicadores clave de las empresas como son la rentabilidad económica y rentabilidad financiera representadas por el ROA Y ROE.
Citing Slavery Project
Authors: Dakho Audrea , Morgan Henry , Krishen Ilina , Simard Justin
Published: October 2023

Tribal Constitutions, Citing Slavery, andPetitioning for Freedom are digital legal history projects focused onexpressions of sovereignty within tribal constitutions, the remnants of slaveryin modern law, and the underexamined role of habeas petitioners in challengingcoercion and confinement in the long-nineteenth-century United States. Eachproject deploys legal databases differently, but with the shared goal ofcontributing key insights to legal historical scholarship and offeringinterfaces that appeal to a broad, public audience.
A Bibliometric Analysis of Omnichannel and Customer Satisfaction
Authors: Ismail Siti Farahhani , Zahari Abdul Rahman , Esa Elinda , Nor Asshidin Nor Hazlin , Surbaini Khairul Nizam , Abdullah Azmer Ezwan
Published: October 2023

Many firms have adopted Omnichannel to increase engagement between companies and their customers. As a result, it facilitates the firms to create better customer experience and satisfaction, which also affects a company's earnings. The main aim of this study is to guide the researchers in developing a conceptual framework for omnichannel and customer satisfaction. Thus, this study has employed a bibliometric analysis using articles extracted from the Scopus database between the years 2015 to 2023 to determine the term co-occurrence in research titles and abstracts and the top ten highly cited journals on omnichannel and customer satisfaction.
Готовимся к аккредитации вместе с ЛИМС
Authors: Аверьянова Е.А. , Андрющенко Р.А. , Богдашов С.Н.
Published: October 2023

В России лабораторные информационные менеджмент-системы (ЛИМС) используются в лабораториях различных отраслей промышленности уже более 20 лет. Программное обеспечение ЛИМС является не только средством автоматизации деятельности лаборатории, но и важным инструментом управления ее данными. Наличие ЛИМС помогает справляться с большим количеством информации и упрощает подготовку к аккредитации. Одним из основополагающих нормативных документов для лаборатории на сегодняшний день является ГОСТ ISO/IEC 17025-2019 «Общие требования к компетентности испытательных и калибровочных лабораторий». В ГОСТе указаны требования к управлению данными и информацией, которые содержатся в компьютеризированных системах (в т. ч. ЛИМС). Но как лаборатории документально подготовиться к аккредитации, если у нее внедрена ЛИМС, четкой информации в тексте ГОСТа нет. В статье обсуждается ГОСТ 17025 в части требований к валидации ЛИМС, а также документального подтверждения наличия и применения ЛИМС в лаборатории.
THE 2023 RELEASE OF Cloudy
Authors: Chatzikos Marios , Bianchi Stefano , Camilloni Francesco , Chakraborty Priyanka , Gunasekera Chamani M. , Guzmán Francisco , Milby Jonathan S. , Sarkar Arnab , Shaw Gargi , van Hoof Peter A. M. , Ferland Gary J.
Published: October 2023

We describe the 2023 release of the spectral synthesis code Cloudy. Since the previous major release, migrations of our online services motivated us to adopt git as our version control system. This change alone led us to adopt an annual release scheme, accompanied by a short release paper, the present being the inaugural. Significant changes to our atomic and molecular data have improved the accuracy of Cloudy predictions: we have upgraded our instance of the Chianti database from version 7 to 10; our H- and He-like collisional rates to improved theoretical values; our molecular data to the most recent LAMDA database, and several chemical reaction rates to their most recent UDfA and KiDA values. Finally, we describe our progress on upgrading Cloudy's capabilities to meet the requirements of the X-ray microcalorimeters aboard the upcoming XRISM and Athena missions, and outline future developments that will make Cloudy of use to the X-ray community.
Aproximación a un índice de precariedad laboral en Colombia
Authors: Higuita López Daimer
Published: October 2023

Objetivo: el presente estudio fue proponer un índice para medir la precariedad de los empleos en Colombia.
Diseño/metodología: La metodología empleada fue cuantitativa, dado que su propósito era medir la precariedad, tomada como una variable. Y para cada una de las ocho dimensiones de precariedad, se hizo un análisis descriptivo. La investigación analiza y pondera dichas dimensiones, así como los indicadores de cada una de ellas. Para ello, se realizó, primero, una validación con expertos y, posteriormente, una encuesta aplicada a 365 personas, que laboran en dieciséis sectores económicos.
Resultados: La investigación evidenció que hay mayor precariedad en los cargos donde el nivel de educación exigido para desempeñarlo es menor; que las personas con contrato a término indefinido no reciben un salario equitativo si se compara con la carga laboral; y que, a pesar de la idea preconcebida, en muchas empresas grandes y medianas no existen esquemas de reconocimiento simbólico por el buen desempeño.
Conclusiones: La precariedad laboral va más allá de aspectos materiales como el salario. La precariedad laboral también está presente en empresas medianas y grandes. La precariedad laboral golpea más a los empleos no calificados.
Originalidad: El instrumento construido y validado para el estudio contiene ocho dimensiones de precariedad laboral que son: remuneración económica, balance vida-personal/vida-laboral, incertidumbre laboral, condiciones de trabajo, salud laboral, derechos laborales, vulnerabilidad y políticas organizacionales. El estudio aplica esas dimensiones al caso colombiano.
Obscure gastrointestinal bleeding in a patient with factor VII deficiency: a case controlled with tranexamic acid
Authors: Jeong Kyu Hwa , Choi Young Bae , Kim Yu Bin
Published: October 2023

Factor VII deficiency is a rare, inherited coagulopathy, which can lead to prolonged bleeding. Here, we present a case report of an adolescent with factor VII deficiency who experienced small bowel bleeding that was successfully treated with tranexamic acid. This case highlights the potential use of tranexamic acid as an effective therapeutic option for managing gastrointestinal bleeding in patients with hemostatic insufficiency of unknown etiology.
SCHRITTWEISE
Authors: Katja Münker, Andrea Keiz  , Paula Kramer  , Katja Münker
Published: October 2023

GEH-CHOREOGRAFISCHER BAUKASTEN
Hier finden Sie eine Zusammenstellung von Experimenten, Fragen zur Forschung und Reaktionen der Teilnehmer.
SCHRITTWEISE engl. Version
Authors: Katja Münker, Andrea Keiz  , Katja Münker
Published: October 2023

WALKING-CHOREOGRAPHY KIT
You will find a collection of experiments, questions to the research and reactions of participants.
Feel free to use it as a playground.
Home range analysis and habitat preferences of wolves recolonising Central European human-dominated landscapes
Authors: Vorel Aleš , Kadlec Ivo , Toulec Tadeáš , Selimovic Aldin , Horníček Jan , Vojtěch Oldřich , Mokrý Jan , Pavlačík Lukáš , Arnold Walter , Cornils Jessica , Kutal Miroslav , Duľa Martin , Žák Lukáš , Bartak, Vojta
Published: October 2023

Decades of persecution resulted in the long-term absence of Grey wolves
(Canis lupus) from most European countries. However, recent changes in
both legislation and public attitudes toward wolves have eased the
pressure and, over the last 20 years, wolves have begun rapidly
re-establishing territories in their previous Central European habitats.
Unfortunately, those habitats are now heavily altered by humans.
Understanding the spatial ecology of wolves in such highly modified
environments is crucial, given the high potential for conflict and the
need to reconcile their return with multiple human concerns. We equipped
twelve wolves (from eight packs) in five Central European areas with GPS
collars and calculated their monthly home ranges using Autocorrelated
Kernel Density Estimation. In addition, we used ESA WorldCover data to
assess the mosaic of available habitats within each home range. Home
range size for most wolves (84.6%) ranged from 56.4 to 259.7 km2. Our
data confirmed the general seasonal pattern for breeding individuals,
with smaller apparent home ranges during the reproduction phase and
non-breeders showing no specific pattern. Somewhat predictably, our
wolves showed a general preference for remote areas, and especially
forests. Some animals within military training areas also showed a
broader preference for grasslands, which could be influenced by the
specific land use of this habitat type and the high availability of
prey. Our results provide a comprehensive insight into the ecology of
wolves during their re-colonisation of Central Europe. Though wolves are
spreading relatively rapidly across Central European landscapes, their
permanent reoccupation remains uncertain due to conflicting concerns
with the human population. To secure the restoration of European wolf
populations, further robust biological data, including data on spatial
ecology, will be needed to clearly identify the management implications.
Effectiveness of miniscrew-supported maxillary molar distalization according to temporary anchorage device features and appliance design: systematic review and meta-analysis
Authors: Ceratti Chiara , Serafin Marco , Del Fabbro Massimo , Caprioglio Alberto
Published: October 2023

Objectives

To evaluate the effectiveness of distalizing maxillary first molars (U6) by temporary anchorage devices (TADs) according to their location (palatal, buccal, and zygomatic), their number, and appliance design.

Materials and Methods

An electronic search of maxillary molar distalization with TADs was done through April 2023. After study selection, data extraction, and risk-of-bias assessment, meta-analyses were performed for the extent of distalization, distal tipping, and vertical movement of U6 using the generic inverse variance and random-effects model. The significance level was set at 0.05.

Results

Forty studies met the inclusion criteria: 4 randomized controlled trials (RCTs), 13 prospective studies, and 23 retrospective studies (total of 1182 patients). Distalization of the U6 was not significantly greater (P = .64) by palatal (3.74 mm) and zygomatic (3.68 mm) than by buccal (3.23 mm) TADs. Distal tipping was significantly higher (P < .001) in nonrigid (9.84°) than in rigid (1.97°) appliances. Vertical movement was mostly intrusive and higher but not significantly different (P = .28) in zygomatic anchorage (−1.16 mm).

Conclusions

Distalization of U6 with TADs can be an effective and stable treatment procedure, especially when performed with rigid palatal appliances. However, further RCTs or prospective cohort studies are strongly recommended to provide more clinical evidence.
Sensory phenotypes provide insight into the natural course of diabetic polyneuropathy
Authors: Tsilingiris Dimitrios , Schimpfle Lukas , von Rauchhaupt Ekaterina , Sulaj Alba , Seebauer Lukas , Herzig Stephan , Szendroedi Julia , Kopf Stefan , Κender Ζoltan
Published: October 2023

We aimed to investigate the characteristics and longitudinal course of sensory phenotypes identified through Quantitative Sensory Testing in the frame of diabetic polyneuropathy (DSPN). 316 individuals with diabetes mellitus (DM) were examined (78.8% T2DM), of which 250 were follow-up visits 1, 2 and/or 4 (2.88±1.27) years. Allocation into four sensory phenotypes (healthy, thermal hyperalgesia-TH, mechanical hyperalgesia-MH, and sensory loss-SL) at every timepoint was based on QST profiles of the right foot. Cross-sectional analyses demonstrated a gradual worsening of clinical and electrophysiological sensory findings, and increased DSPN prevalence across the groups culminating in SL. Motor nerve impairment was observed solely in SL. Longitudinal analysis revealed a distinct pattern of the phenotype’s developmental course (healthy to TH, to MH, to SL). Baseline MH exhibited the highest risk of transition to SL. Regression to healthy was uncommon and mostly observed in TH. Among those without DSPN initially, presence or future occurrence of SL was associated with a three- to fivefold higher likelihood of DSPN development. Our comprehensive longitudinal study of phenotyped patients with DM elucidates the natural course of DSPN. QST-based sensory examination together with other tools for phenotyping may perhaps be useful to determine the natural course of diabetic neuropathy, to identify patients at high risk for DSPN and guide preventive and therapeutic interventions.
La propiocepción en la técnica de la palada del remo indoor intelectual
Authors:   Entrenadora de Para Ciclismo FEDEDI, Lema Guallichico Mélida Fernanda , Aules León Nataly ,   Universidad Técnica del Norte, Ibarra, Ecuador, Benavides Portilla Patricio Henry ,   Entrenador Remo Indoor FEDEDI, Moposita Caillamara Fredy Geovanny ,   Jefe deEntrenadores del Comité Paralímpico Ecuatoriano
Published: October 2023

La técnica es una capacidad es un pilar que permite efectivizar el gasto energético y más cuando se trata de deportistas con discapacidad intelectual, el objetivo fue determinar la incidencia de la propiocepción en la técnica de la palada de los deportistas de Remo Indoor en la Federación de Ecuatoriana de Deportes para Personas con Discapacidad Intelectual FEDEDI, se aplicó un diseño de investigación cuasi experimental a través de un pre test y post test, la técnica que se utilizó para la recolección de los datos fue la técnica de la observación a través de una lista de cotejo, con 3 escalas: deficiente, buena y muy buena. La muestra fueron 13 deportistas varones con discapacidad intelectual con una media de edad de 23,15 ± 3.80 años. El análisis de los datos fue con el programa SPSS v.25, los resultados fueron una media del % de discapacidad intelectual de 52,53%, por lo que se tuvo que enfatizar en el método de repeticiones para la ejecución de los ejercicios propioceptivos, se emplearon adaptaciones pedagógicas y didácticas debido a sus limitaciones cognitivas, la evidencia encontrada en la escala: deficiente técnica fue en el pre test 30,77% y en el post test 7,69%, en la escala de: buena técnica en el pre test fue de 53,85% y en el post test 15,38% y en la escala de: muy buena técnica en el pre test fue de 15,38% y en el post test un 76,92%, se concluye que la aplicación de los ejercicios propioceptivos mejoraron la técnica de la palada de forma significativa en los deportistas intelectuales de Remo Indoor.
Pengaruh Promosi dan Kualitas Pelayanan Elektronik “Aku Online” terhadap Kepuasan Masyarakat pada Kantor Dinas Kependudukan dan Pencatatan Sipil Pemerintah Kabupaten Buleleng
Authors: Purnamayanti Putu Ria , Heryanda Komang Krisna
Published: October 2023

This study aims to examine (1) the effect of promotion and quality of electronic services "AKU Online" on community satisfaction at the Office of Population and Civil Registration of the Buleleng Regency Government, (2) The effect of promotion on community satisfaction at the Office of Population and Civil Registration of the Buleleng Regency Government , (3) the effect of electronic service quality on community satisfaction at the Office of Population and Civil Registration of the Buleleng Regency Government. The subject of this research is the community at the Population and Civil Registration Office of the Buleleng Regency Government and the objects of this research are promotion, quality of electronic services, and community satisfaction. The number of samples used is 100 respondents with purposive sampling. The research design is causal quantitative and the data collected was analyzed using multiple linear regression analysis with the SPSS 22.0 for Windows application. The results showed that (1) promotion and electronic service quality had a positive and significant effect on community satisfaction, (2) promotion had a positive and significant effect on community satisfaction, (3) electronic service quality had a positive and significant effect on community satisfaction
Pengaruh Kepemimpinan Pelayanan, Manajemen Perubahan, dan Iklim Kerja Terhadap Kinerja Pegawai Keuangan Universitas Pendidikan Ganesha di Masa Covid-19
Authors: Adiastra Nyoman Teja , Rahmawati Putu Indah , Telagawathi Ni Luh Wayan Sayang
Published: October 2023

This study aims to determine: (1) the influence of service leadership, (2) change management, (3) and work climate on the performance of employees of the finance department at Ganesha University of Education during the Covid-19 period, both partially and simultaneously. This research is a quantitative study of factor exposure. The sample for this study were all members of the population, such as all employees in charge of the finance department at the Ganesha University of Education (Undiksha), which totaled 35 people. The independent variables of this study are service leadership, change management, and work climate, while the dependent variable is employee performance. Data was collected with a valid and reliable questionnaire. Data were analyzed by multiple linear regression analysis at a significance level of 95%. The results showed that: (1) service leadership has a positive and significant effect to employee performance, (2) change management has a positive and significant effect to employee performance, (3) work climate has a positive and significant effect on employee performance, and (4) simultaneously service leadership, change management, and work climate have a positive and significant effect on the performance of Undiksha finance staff during the Covid-19 period. The contribution of the independent variables of service leadership, change management, and work climate to the performance of Undiksha finance staff during the Covid-19 period was 66.6%. It is suggested to the leadership of Undiksha to continue implementing service leadership, implementing change management, and creating a conducive work climate in an effort to improve the performance of the Undiksha finance department
Pengaruh Citra Merek dan Kualitas Produk Terhadap Keputusan Pembelian Handphone Merek Vivo di Sarijaya Cellular
Authors: Galuh Khairunnisa  , Suwena Kadek Rai
Published: October 2023

Findings from research are what we're looking for: (1) the impact of brand image on buying decisions for Vivo brand mobile phones at Sarijaya Cellular Banyupoh, (2) the impact of product quality on purchasing decisions for Vivo brand mobile phones at Sarijaya Cellular Banyupoh, and (3) the impact of brand image and product quality on the decision to purchase a Vivo brand mobile phone at Sarijaya Cellular Banyupoh. This type of research is quantitative research. The population in this study were all consumers of Vivo brand mobile phones in Sarijaya Cellular Banyupoh. The number of population in this study is unknown because there is no exact data on the number of consumers of Vivo brand mobile phones in Sarijaya Cellular Banyupoh. The number of samples is 105. The sample technique used is purposive sampling technique. methods for gathering data through questionnaires and data analysis, namely multiple linear regression analysis. The SPSS 16 for Windows program is used to process the t test and F test for the hypothesis test. The study's findings show that  (1) brand image has a positive and significant impact on purchasing choices for Vivo cellphones in Sarijaya cellular Banyupoh with a significance value of 0.000 <0.05, (2) product quality has a positive and significant impact on purchasing choices for Vivo cellphones in Sarijaya cellular Banyupoh with a significance value of 0.000 <0.05, and (3) brand image and product quality have a positive and significant impact on the decision to purchase of 0.000 <0.05.
Reducing CO2 by Investing Solar Panel to Support Green Industry and Increasing Competitiveness Manufacturing Industry in Indonesia
Authors: Prasetyo1 Yugo , Saputri Selly Nissa
Published: October 2023

Carbon dioxide emission (CO2) is one of the causes of climate change and global warming that affects air quality and threatens all creature’s lives. ASEAN countries have a big impact and Indonesia, as one of the ASEAN members, has a big contribution in increasing CO2 emission compared to other members, especially in the manufacturing industry sector. Indonesia has adapted the Green Industry and the Government supports renewable energy development and gives incentives such as tax allowance, tax holiday for large investment  spur industrialization in Indonesia. Using solar panels is a manufacturer's strategy to fulfill demands and reduce the CO2 emission as targeted by the Government. This study is to examine the feasibility of the investment of solar panels to transform and adapt with climate change and to contribute to reducing the CO2 emission, increasing competitiveness in the manufacturing sector.