bluuebunny/crossref_metadata_2025 huggingface dataset:
A distinctive outlook for children’s oral health
Authors: B. Amrutha , C. Anitha , Thimmegowda Umapathy , D. Amudha , D. Pavana
Published: February 2024

‘Prevention is better than cure’! This saying holds well in the field of dentistry too. Prevention of oral health diseases is one of the important aspects of pediatric dentistry. It can be done by identifying dental risk individuals at an early age and by adopting strategies which include various behavior modifications and anticipatory guidance as well as by establishing a dental home by one year of age. The distinct concept of a dental home is where preventive oral health supervision and emergency care are taken care of. Early establishment of the dental home in the child’s life can expose a child to prevention and early interventions before any dental problem arises.

Keywords: Pediatric dentistry, Prevention, Oral health, medical home, dental home, AAPD, first dental visit.
Non-surgical management of an Extra-oral sinus tract of an odontogenic origin-A Case Report
Authors: Kachari Megha , Meena N.` , M. S. Adarsha
Published: February 2024

A longstanding odontogenic infection often leads to the formation of suppuration, which is drained either intra-orally or extra-orally through a sinus tract. Being a rare condition, the extraoral sinus tract of odontogenic origin is usually misdiagnosed. As it is rightly said that a correct diagnosis is three-fourths the remedy, diagnosing the odontogenic extraoral sinus tract is of prime importance for its effective management. So, this case report demonstrates the diagnosis and the non-surgical endodontic management of an extraoral sinus tract.
Key Words - Cutaneous lesion, Extra-oral sinus tract, Non-surgical endodontic management, Odontogenic origin
Three-dimensional array of microbubbles sonoporation of cells in microfluidics
Authors: Huang Guangyong , Lin Lin , Liu Quanhui , Wu Shixiong , Chen Jiapeng , Zhu Rongxing , You Hui , Sun Cuimin
Published: February 2024

Sonoporation is a popular membrane disruption technique widely applicable in various fields, including cell therapy, drug delivery, and biomanufacturing. In recent years, there has been significant progress in achieving controlled, high-viability, and high-efficiency cell sonoporation in microfluidics. If the microchannels are too small, especially when scaled down to the cellular level, it still remains a challenge to overcome microchannel clogging, and low throughput. Here, we presented a microfluidic device capable of modulating membrane permeability through oscillating three-dimensional array of microbubbles. Simulations were performed to analyze the effective range of action of the oscillating microbubbles to obtain the optimal microchannel size. Utilizing a high-precision light curing 3D printer to fabricate uniformly sized microstructures in a one-step on both the side walls and the top surface for the generation of microbubbles. These microbubbles oscillated with nearly identical amplitudes and frequencies, ensuring efficient and stable sonoporation within the system. Cells were captured and trapped on the bubble surface by the acoustic streaming and secondary acoustic radiation forces induced by the oscillating microbubbles. At a driving voltage of 30 Vpp, the sonoporation efficiency of cells reached 93.9% ± 2.4%.
Experimental investigations on the compaction energy for a robotic rammed earth process
Authors: Schmitz Linus Paul , Gosslar Joschua , Dorresteijn Evelien , Lowke Dirk , Kloft Harald
Published: February 2024

Rammed earth is a construction material with a long history of traditional manufacturing. Due to its low environmental impact, positive impact on indoor climate and completely recyclable nature, its demand is also increasing in modern construction industry. However, as a consequence of the predominantly manual manufacturing processes, the production of rammed earth components is both inefficient and costly. Through the implementation of automated and robot-aided fabrication processes in the field of rammed earth construction, the opportunity to advance the digitalization of the field can raise to a new level. In this paper, general studies on the interrelation of process and material parameters and their influence on the compaction results were conducted as a basis for the development of a prototypic robotic manufacturing process. The results show that reducing the layer height can significantly decrease the impact energy. Additionally, it was shown that there is a minimum number of strokes and a minimum ramming frequency required for sufficient compaction. Furthermore, a possible workflow for a specific control of the required dry density through variation of the compaction energy with regard to the present moisture content was identified.
Gender differences in all-cause and cardiovascular mortality among US adults: from NHANES 2005–2018
Authors: Lv Ying , Cao Xiaodi , Yu Kai , Pu Jie , Tang Zhiguo , Wei Na , Wang Junkui , Liu Fuqiang , Li Shangjian
Published: February 2024

Background

Gender disparities in mortality have drawn great interest, with previous studies identifying various biological, social, and behavioral factors contributing to the observed gender differences. This study aims to identify the sources of gender disparities in mortality rates and quantify the extent to which these factors mediate the gender differences in all-cause mortality.

Methods

Data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2018 were analyzed. A total of 38,924 participants were included in the study. Gender information, socioeconomic status, lifestyle factors, and baseline disease status were obtained through questionnaires. Blood samples were collected to assess serological indicators. All-cause and cardiovascular mortality were considered as primary and secondary outcomes, respectively.

Results

The study with an average age of 50.1 ± 17.9 years. Among the participants, 50.7% were women, and 41.8% were non-Hispanic White. The median follow-up length was 87 months [Inter-Quartile Range (IQR): 47–128]. Men showed higher rates of all-cause and cardiovascular mortality compared to women in both the general population and the population with cardiovascular disease. After adjustment for potential confounders (age, race, marital status, socioeconomic status, lifestyle level, smoking status, cardiovascular disease, hypertension, diabetes and cancer), the men: women hazard ratios (HRs) for all-cause and cardiovascular mortality were 1.58 [95% Confidence Interval (CI): 1.48–1.68] and 1.60 (95%CI:1.43–1.80) in the general population. Among individuals with cardiovascular disease, the fully adjusted HR for all-cause mortality was 1.34 (95% CI: 1.20 to 1.51), and for cardiovascular mortality, the fully adjusted HRs was 1.52 (95% CI: 1.26 to 1.83). Mediation analysis revealed that uric acid levels significantly mediated the association between gender and all-cause mortality, accounting for 17.53% (95% CI: 11.0% to 23.7%) in the general population and 27.47% (95% CI: 9.0% to 13.6%) in the population with cardiovascular disease.

Conclusions

The study highlights the complex interplay of biological and social factors contributing to gender disparities in mortality. Uric acid was identified as key mediators of the gender-mortality association. These findings can inform targeted interventions aimed at reducing gender disparities in mortality and promoting better public health outcomes.
Satisfaction of adult and pediatric neurologists and neurosurgeons using telehealth during the COVID-19 pandemic in Saudi Arabia: a cross-sectional study
Authors: Algarni Saleh Ayed , Alrashid Maha Hamoud , Aldayel Mohammed Sultan , Allowaihiq Lujain Habeeb , Almuqbil Abdulaziz Ali , Albarrak Anas Mohammad , Almobarak Sulaiman
Published: February 2024

Objectives

Telehealth has become increasingly important in achieving universal health coverage. It offers doctors and their patients' convenience, including providing quality care at reduced costs. During the coronavirus disease (COVID)-19 pandemic, telehealth has been a vital tool for remote healthcare services. This study aimed to assess the satisfaction of adult and pediatric neurologists and neurosurgeons using telehealth, during the COVID-19 pandemic in Saudi Arabia.

Methods

This study had 348 participants. It was conducted among adult and pediatric neurologists and neurosurgeons using telehealth technology at their clinics between February and June 2021. The self-administered questionnaire included sociodemographic data, behavior in using telehealth, and an assessment of satisfaction with telehealth; the SPSS Windows software version 26 was used to analyze the data.

Results

The most common age group was 25–34 years (42.8%), with men dominating (68.4%). The mean satisfaction score was 25.9 (SD 3.91) out of 33 points, with 90.2% of respondents satisfied with telehealth and 9.8% dissatisfied. Working in an academic center or private hospital, being a first-time telehealth user, using messages as a telehealth method, and using telehealth daily were associated with increased satisfaction with telehealth use.

Conclusion

The satisfaction of adult and pediatric neurologists and neurosurgeons with telehealth was high. Although physicians still preferred face-to-face interviews, they recognized the benefits of telehealth in strengthening the patient–provider relationship, improving productivity, and integrating into daily workflows. The satisfaction levels align with past studies, but physical examination needs should be considered. Telehealth is suitable for follow-up visits and varies across subspecialties.
Effects of electrode materials and potential gradient on electro-osmotic consolidation for marine clayey soils
Authors: Jin Haihui , Zhang Lei , Wang Binghui , Fang Chen , Wang Liyan
Published: February 2024

This study conducted experimental investigations into the effects of electrode material and potential gradient on the effectiveness of electro-osmotic consolidation (EO) in strengthening soft soils. Seven laboratory tests were conducted on high-water-content marine clayey soils through EO. In these experimental tests, four different types of electrodes made of steel, copper, aluminum, and composite carbon fiber (CCF) were employed in four tests each to evaluate the consolidation effectiveness. Additionally, four tests, one was the comparitive study for different eletrode materials, were carried out to determine the optimal gradient for the EO using CCF electrode. Several critical properties of the tested soils were examined and evaluated in this study, including the effective voltage utilization, potential distribution, water discharge, discharge rate, energy consumption, and soil bearing capacity. The test results indicated that the CCF electrode had superior performance in water discharge, discharge rate, and average soil water content compared to metal electrodes. Furthermore, CCF led to uniform enhancement of soil strength, with treated soil bearing capacities 6.3 to 12 times higher than initial values, and 1.9 to 2.5 times higher than those attained with metal electrodes. Additionally, an effective potential gradient of 1 V/cm was identified for the EO with the CCF electrode, providing a higher discharge rate and a larger soil strength in a uniform distribution. Moreover, the use of CCF electrode significantly reduced corrosion compared to metal electrodes during the consolidation process, further contributing to improved consolidation efficiency. This study offers valuable insights and recommendations for the utilization of CCF in marine clayey soils, effectively addressing the challenges posed by electrode corrosion and high energy consumption in EO applications.
Gender equity in university students in Mexico City, after 20 months of remote classes during the COVID-19 pandemic
Authors: Saldívar-Garduño Alicia , Alarcón-Aguilar Adriana , Cervantes-Ríos Elsa , López-Diazguerrero Norma Edith , Gómez-González Beatriz , Gaitán-González Mercedes Jatziri , Konigsberg Mina
Published: February 2024

Several studies have reported that university students were affected during the months of confinement due to the COVID-19 pandemic. In Mexico, public and private universities were the last to resume face-to-face activities, so the students stayed in remote classes for almost 20 months. Because of gender inequities in higher education, it is essential to analyze the differential effects of remote learning on male and female students in terms of their physical and mental health, motivation, school achievement, and students’ adaptation to changes. Here we surveyed 573 students from Universidad Autónoma Metropolitana, Campus Iztapalapa in Mexico City, using a self-administration survey online. Our results showed that female students had more work overload at home, and felt more affected in their physical and mental health compared to men. Despite these difficulties, women were more willing to get ahead in academic and work settings.
Computational optical imaging: challenges, opportunities, new trends, and emerging applications
Authors: Xiang Meng , Liu Fei , Liu Jinpeng , Dong Xue , Liu Qianqian , Shao Xiaopeng
Published: February 2024

Computational imaging technology (CIT), with its many variations, addresses the limitations of industrial design. CIT can effectively overcome the bottlenecks in physical information acquisition, model development, and resolution by being tightly coupled with mathematical calculations and signal processing in information acquisition, transmission, and interpretation. Qualitative improvements are achieved in the dimensions, scale, and resolution of the information. Therefore, in this review, the concepts and meaning of CIT are summarized before establishing a real CIT system. The basic common problems and relevant challenging technologies are analyzed, particularly the non-linear imaging model. The five typical imaging requirements–distance, resolution, applicability, field of view, and system size–are detailed. The corresponding key issues of super-large-aperture imaging systems, imaging beyond the diffraction limit, bionic optics, interpretation of light field information, computational optical system design, and computational detectors are also discussed. This review provides a global perspective for researchers to promote technological developments and applications.
The potential of IFN-λ, IL-32γ, IL-6, and IL-22 as safeguards against human viruses: a systematic review and a meta-analysis
Authors: Sattar Areej A. , Qaiser Ariba , Kausar Hina , Aqil Sarah , Mudassar Rida , Manzoor Sobia , Ashraf Javed
Published: February 2024

Many studies have investigated the antiviral activity of cytokines, including interleukin-6 (IL-6), interleukin-22 (IL-22), interleukin-32 gamma (IL-32γ), and interferon-lambda (IFN-λ) in diverse populations. This study aims to evaluate the role of these cytokines in inhibition of various human and animal viruses when administered exogenously. A comprehensive meta-analysis and systematic review were conducted on all the relevant studies from three databases. Standard mean differences (SMDs) of overall viral inhibition were used to generate the difference in the antiviral efficacy of these cytokines between control and experimental groups. A total of 4,618 abstracts for IL-6, 3,517 abstracts for IL-22, 2,160 abstracts for IL-32γ, and 1,026 abstracts for IFN-λ were identified, and 7, 4, 8, and 35 studies were included, respectively, for each cytokine. IFN-λ (SMD = 0.9540; 95% CI: 0.69–0.22) and IL-32γ (SMD = 0.459; 95% CI: 0.02–0.90) showed the highest influence followed by IL-6 (SMD = 0.456; CI: −0.04–0.95) and IL-22 (SMD = 0.244; 95% CI: −0.33–0.81). None of the cytokines represented heterogeneity (tau² > 0), but only IFN-λ indicated the funnel plot asymmetry (p = 0.0097). Results also indicated that IFN-λ and IL-32γ are more potent antivirals than IL-6 and IL-22. The collective findings of this study emphasize that exogenously administered pro-inflammatory cytokines, specifically IFN-λ and IL-32, exhibit a significant antiviral activity, thereby underscoring them as potent antiviral agents. Nonetheless, additional research is required to ascertain their clinical utility and potential for integration into combinatorial therapeutic regimens against viral infections.
Immune escape and metastasis mechanisms in melanoma: breaking down the dichotomy
Authors: Shirley Carl A. , Chhabra Gagan , Amiri Deeba , Chang Hao , Ahmad Nihal
Published: February 2024

Melanoma is one of the most lethal neoplasms of the skin. Despite the revolutionary introduction of immune checkpoint inhibitors, metastatic spread, and recurrence remain critical problems in resistant cases. Melanoma employs a multitude of mechanisms to subvert the immune system and successfully metastasize to distant organs. Concerningly, recent research also shows that tumor cells can disseminate early during melanoma progression and enter dormant states, eventually leading to metastases at a future time. Immune escape and metastasis have previously been viewed as separate phenomena; however, accumulating evidence is breaking down this dichotomy. Recent research into the progressive mechanisms of melanoma provides evidence that dedifferentiation similar to classical epithelial to mesenchymal transition (EMT), genes involved in neural crest stem cell maintenance, and hypoxia/acidosis, are important factors simultaneously involved in immune escape and metastasis. The likeness between EMT and early dissemination, and differences, also become apparent in these contexts. Detailed knowledge of the mechanisms behind “dual drivers” simultaneously promoting metastatically inclined and immunosuppressive environments can yield novel strategies effective in disabling multiple facets of melanoma progression. Furthermore, understanding progression through these drivers may provide insight towards novel treatments capable of preventing recurrence arising from dormant dissemination or improving immunotherapy outcomes.
SARS-CoV-2 spike-reactive naïve B cells and pre-existing memory B cells contribute to antibody responses in unexposed individuals after vaccination
Authors: Teng Shishan , Hu Yabin , Wang You , Tang Yinggen , Wu Qian , Zheng Xingyu , Lu Rui , Pan Dong , Liu Fen , Xie Tianyi , Wu Chanfeng , Li Yi-Ping , Liu Wenpei , Qu Xiaowang
Published: February 2024

Introduction

Since December 2019, the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) has presented considerable public health challenges. Multiple vaccines have been used to induce neutralizing antibodies (nAbs) and memory B-cell responses against the viral spike (S) glycoprotein, and many essential epitopes have been defined. Previous reports have identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-reactive naïve B cells and preexisting memory B cells in unexposed individuals. However, the role of these spike-reactive B cells in vaccine-induced immunity remains unknown.

Methods

To elucidate the characteristics of preexisting SARS-CoV-2 S-reactive B cells as well as their maturation after antigen encounter, we assessed the relationship of spike-reactive B cells before and after vaccination in unexposed human individuals. We further characterized the sequence identity, targeting domain, broad-spectrum binding activity and neutralizing activity of these SARS-CoV-2 S-reactive B cells by isolating monoclonal antibodies (mAbs) from these B cells.

Results

The frequencies of both spike-reactive naïve B cells and preexisting memory B cells before vaccination correlated with the frequencies of spike-reactive memory B cells after vaccination. Isolated mAbs from spike-reactive naïve B cells before vaccination had fewer somatic hypermutations (SHMs) than mAbs isolated from spike-reactive memory B cells before and after vaccination, but bound SARS-CoV-2 spike in vitro. Intriguingly, these germline-like mAbs possessed broad binding profiles for SARS-CoV-2 and its variants, although with low or no neutralizing capacity. According to tracking of the evolution of IGHV4-4/IGKV3-20 lineage antibodies from a single donor, the lineage underwent SHMs and developed increased binding activity after vaccination.

Discussion

Our findings suggest that spike-reactive naïve B cells can be expanded and matured by vaccination and cocontribute to vaccine-elicited antibody responses with preexisting memory B cells. Selectively and precisely targeting spike-reactive B cells by rational antigen design may provide a novel strategy for next-generation SARS-CoV-2 vaccine development.
The PFILSTM model: a crack recognition method based on pyramid features and memory mechanisms
Authors: Chen Bin , Fan Mingyu , Li Ke , Gao Yusheng , Wang Yifu , Chen Yiqian , Yin Shuohui , Sun Junxia
Published: February 2024

Crack detection is a crucial task for the structural health diagnosis of buildings. The current widely used manual inspection methods have inherent limitations and safety hazards, while traditional digital image processing methods require manual feature extraction and also have substantial limitations. In this paper, we propose a crack recognition method based on pyramid features and memory mechanisms that leverages a U-shaped network, long short-term memory mechanisms, and a pyramid feature design to address the recognition accuracy, robustness, and universality issues with deep learning-based crack detection methods in recent years. Experiments were conducted on four publicly available datasets and one private dataset. Compared with the commonly used FCN8s, SegNet, UNet, and DeepLabv3+ models and other related studies using the same evaluation criteria and datasets, our proposed model shows better overall performance in terms of all metrics evaluated.
Investigation of mechanical properties of silver-doped diamond-like carbon coating by varying deposition temperature
Authors: Ghadai Ranjan Kr. , Shanmugasundar G. , Vanitha M. , Čep Robert , Das Soham , Swain Bibhu P.
Published: February 2024

The present work shows the influence of deposition temperatures on the mechanical properties of silver (Ag)-doped diamond-like carbon (DLC) coating synthesized by the thermal chemical vapor deposition (CVD) technique. The deposited film showed excellent mechanical and tribological behavior with respect to the lower deposition temperatures. From the EDS analysis, it was confirmed that the percentage of Ag decreased from 9.8% to 8.4% as the deposition temperature increased. The nanoindentation tests at different loads were extensively carried out to observe the mechanical properties of the coating with respect to various deposition temperatures. The coating hardness (H) and Young’s modulus (E) decreased with the rise in furnace temperature, and the Hmax. and Emax. were observed as 29.71 and 251.19 GPa, respectively, for the Ag-DLC coating grown at 800°C at a load of 20 mN. In comparison to other Ag-DLC thin films made using different deposition techniques, the residual stress (σ) was significantly reduced, reaching 0.45 GPa, which is extremely low.
Relationship between sheep feces scores and gastrointestinal microorganisms and their effects on growth traits and blood indicators
Authors: Yang Xiaobin , Wang Jianghui , Cheng Jiangbo , Zhang Deyin , Huang Kai , Zhang Yukun , Li Xiaolong , Zhao Yuan , Zhao Liming , Xu Dan , Ma Zongwu , Liu Jia , Huang Zhiqiang , Li Chong , Tian Huibin , Weng Xiuxiu , Wang Weimin , Zhang Xiaoxue
Published: February 2024

Fecal scores are crucial for assessing the digestive and gastrointestinal status of animals. The Bristol fecal scoring system is a commonly used method for the subjective evaluation of host feces, there is limited research on fecal scoring standards for fattening Hu sheep. In this study, Hu sheep were collected for rumen, rectum, and colon contents for 16S rDNA sequencing. 514 Hu sheep feces were scored based on the Bristol fecal scoring system, and production performance at each stage was measured. Finally, we developed the scoring standard of the manure of Hu sheep in the fattening period (a total of five grades). The result shows that moisture content significantly increased with higher grades (p < 0.05). We analyzed the relationship between fecal scores and production traits, blood indices, muscle nutrients, and digestive tract microorganisms. The growth traits (body weight, body height, body length, average daily gain (ADG), and average daily feed intake (ADFI) during 80–180 days), body composition traits of the F3 group, and the carcass traits were found to be significantly higher (p < 0.05) than those of the F1 and F2 groups. There was no significant difference in gastrointestinal microflora diversity among all groups (p > 0.05). Significant differences were observed in Aspartate aminotransferase, Glucose, Total bilirubin, and Red Blood Cell Count between groups (p < 0.05). The mutton moisture content in group F4 was significantly higher than in the other groups, and the protein content was also the lowest (p < 0.05). The results of the correlation analysis demonstrated that Actinobacteria, Peptostreptococcaceae, Acidaminococcales, Gammaproteobacteria, and Proteobacteria were the significant bacteria affecting fecal scores. In addition, Muribaculaceae and Oscillospiraceae were identified as the noteworthy flora affecting growth performance and immunity. This study highlights the differences in production traits and blood indicators between fecal assessment groups and the complex relationship between intestinal microbiota and fecal characteristics in Hu sheep, suggesting potential impacts on animal performance and health, which suggest strategies for improved management.
Enriched oxygen improves age-related cognitive impairment through enhancing autophagy
Authors: Wang Shengyuan , Chen Bengang , Yuan Minghao , Liu Shu , Fan Haixia , Yang Xu , Zou Qian , Pu Yinshuang , Cai Zhiyou
Published: February 2024

Age-related cognitive impairment represents a significant health concern, with the understanding of its underlying mechanisms and potential interventions being of paramount importance. This study aimed to investigate the effects of hyperbaric oxygen therapy (HBOT) on cognitive function and neuronal integrity in aged (22-month-old) C57BL/6 mice. Male mice were exposed to HBOT for 2 weeks, and spatial learning and memory abilities were assessed using the Morris water maze. We employed transcriptome sequencing and Gene Ontology (GO) term enrichment analysis to examine the effects of HBOT on gene expression profiles, with particular attention given to synapse-related genes. Our data indicated a significant upregulation of postsynapse organization, synapse organization, and axonogenesis GO terms, likely contributing to improved cognitive performance. Moreover, the hyperphosphorylation of tau, a hallmark of many neurodegenerative diseases, was significantly reduced in the HBO-treated group, both in vivo and in vitro. Transmission electron microscopy revealed significant ultrastructural alterations in the hippocampus of the HBOT group, including an increase in the number of synapses and the size of the active zone, a reduction in demyelinated lesions, and a decreased number of “PANTHOS.” Furthermore, Western blot analyses confirmed the upregulation of PSD95, BDNF, and Syn proteins, suggesting enhanced synaptic plasticity and neurotrophic support. Moreover, HBOT increased autophagy, as evidenced by the elevated levels of Beclin-1 and LC3 proteins and the reduced level of p62 protein. Finally, we demonstrated that HBOT activated the AMPK-mTOR signaling pathway, a critical regulator of autophagy. Notably, our findings provide novel insights into the mechanisms by which HBOT ameliorates age-related cognitive impairment, suggesting the potential therapeutic value of this approach.
Exploring the dynamic interplay between learning and working memory within various cognitive contexts
Authors: Hassanzadeh Zakieh , Bahrami Fariba , Dortaj Fariborz
Published: February 2024

Introduction

The intertwined relationship between reinforcement learning and working memory in the brain is a complex subject, widely studied across various domains in neuroscience. Research efforts have focused on identifying the specific brain areas responsible for these functions, understanding their contributions in accomplishing the related tasks, and exploring their adaptability under conditions such as cognitive impairment or aging.

Methods

Numerous models have been introduced to formulate either these two subsystems of reinforcement learning and working memory separately or their combination and relationship in executing cognitive tasks. This study adopts the RLWM model as a computational framework to analyze the behavioral parameters of subjects with varying cognitive abilities due to age or cognitive status. A related RLWM task is employed to assess a group of subjects across different age groups and cognitive abilities, as measured by the Montreal Cognitive Assessment tool (MoCA).

Results

Analysis reveals a decline in overall performance accuracy and speed with differing age groups (young vs. middle-aged). Significant differences are observed in model parameters such as learning rate, WM decay, and decision noise. Furthermore, among the middle-aged group, distinctions emerge between subjects categorized as normal vs. MCI based on MoCA scores, notably in speed, performance accuracy, and decision noise.
Keeping social distance in a classroom while interacting via a telepresence robot: a pilot study
Authors: Marmor Kristel , Leoste Janika , Heidmets Mati , Kangur Katrin , Rebane Martin , Pöial Jaanus , Kasuk Tiina
Published: February 2024

Introduction

The use of various telecommunication tools has grown significantly. However, many of these tools (e.g., computer-based teleconferencing) are problematic in relaying non-verbal human communication. Telepresence robots (TPRs) are seen as telecommunication tools that can support non-verbal communication.

Methods

In this paper, we examine the usability of TPRs, and communication distance related behavioral realism in communication situations between physically present persons and a TPR-mediated person. Twenty-four participants, who played out 36 communication situations with TPRs, were observed and interviewed.

Results

The results indicate that TPR-mediated people, especially women, choose shorter than normal communication distances. The type of the robot did not influence the choice of communication distance. The participants perceived the use of TPRs positively as a feasible telecommunication method.

Discussion

When introducing TPRs, situations with greater intrapersonal distances require more practice compared to scenarios where a physically present person communicates with a telepresent individual in the audience. In the latter situation, the robot-mediated person could be perceived as “behaviorally realistic” much faster than in vice versa communication situations.
The imaging dynamic changes in the malignant transformation of an epidermoid cyst: a case report and literature review
Authors: Yang Tian , Hu Jibo , Li Lele , Xu Houyun , Zhang Caijuan , Huang Zhilan , Yang Jun , Zhang Huiqing
Published: February 2024

Malignant transformation of epidermoid cysts is a rare complication. Most of the previously reported cases have involved postoperative malignant transformations. We present a case of malignant transformation of a nonpostoperative epidermoid tumor into squamous cell carcinoma (SCC) that occurred in a 61-year-old Chinese woman. The patient’s initial cranial MRI scan showed an epidermoid cyst with marginal enhancement in the pre-pontine cistern, and the lesion gradually enlarged after 10 months. A craniotomy was performed using to remove part of the tumor via the right retrosigmoid approach, and postoperative pathology confirmed that the transformation of the epidermoid cyst was malignant. Our case study suggests that the possibility of malignant transformation of epidermoid cyst should not be ignored on the basis of enhanced imaging features, regardless of whether they are nodular, annular, or patchy, as is the case for inflammation. Strict follow-up is required for early detection of malignant transformation to prompt correspondingly early clinical treatment.
Pogostemon cablin essential oil affects anxiety- and depressive-like behaviors and the gut microbiota in chronic unpredictable mild stress model rats
Authors: Ouyang Puyue , Kang Dali , You Weijing , Shen Xiaozhong , Mo Xiaolu , Liu Yao
Published: February 2024

The gut microbiota is thought to be an important factor that influences brain processes and behaviors through the gut–brain axis. Pogostemon cablin is used in traditional Chinese medicine (TCM) to treat gastrointestinal symptoms. Patchouli essential oil (PCO), the main active agent in P. cablin, is used in aromatherapy for stress relief. The aim of our study was to investigate the effects of orally administered PCO on anxiety- and depressive-like behaviors and the gut microbiota. We constructed a rat model of chronic unpredictable mild stress (CUMS) and explored the anxiolytic- and antidepressant-like effects of PCO using the open field test (OFT) and forced swim test (FST). Changes in the abundance of the gut microbiota, short-chain fatty acids (SCFAs), and other related molecules were assessed to determine the role of the gut microbiota. Our results showed that CUMS induced an anxiety-like phenotype in the OFT, which was reversed by PCO, and that PCO also significantly mitigated the depression-like behaviors caused by CUMS in the FST. Furthermore, we found that PCO increased the relative abundances of several probiotics, including Bacteroides and Blautia, and decreased the relative abundances of Ruminococcus_1 and Ruminococcus_2, which were increased by CUMS. Regarding SCFAs, the metabolites of the gut microbiota, PCO increased the concentration of propionic acid and decreased that of caproic acid. Finally, PCO restored the serotonin (5-hydroxytryptamine, 5-HT) level in the hippocampus, which had been decreased by CUMS. The results of this study suggested that PCO can improve stress-related anxiety- and depression-like behaviors and might exert its effects on the central nervous system through interactions with the gut microbiota.
miR-939-3p induces sarcoma proliferation and poor prognosis via suppressing BATF2
Authors: Xu Wanwen , Huang Yinghui , Lei Zengjie , Zhou Jie
Published: February 2024

Background

Sarcoma is a rare and aggressive malignancy with poor prognosis, in which oncogene activation and tumor suppressor inactivation are involved. Accumulated studies suggested basic leucine zipper transcription factor ATF-like 2 (BATF2) as a candidate tumor suppressor, but its specific role and mechanism in sarcoma remain unclear.

Methods

The expression levels of BATF2 and miR-939-3p were evaluated by using human sarcoma samples, cell lines and xenograft mouse models. Bioinformatics analysis, qPCR, Western blot, cell proliferation assay, overexpression plasmid construction, point mutation and dual luciferase reporter assay were utilized to investigate the role and mechanism of miR-939-3p in sarcoma.

Results

In this study, we demonstrated that the expression of BATF2 was downregulated in human sarcoma tissues and cell lines. The downregulation of BATF2 was negatively associated with the prognosis of sarcoma patients. Subsequent bioinformatic prediction and experimental validations showed that BATF2 expression was reduced by microRNA (miR)-939-3p mimic and increased by miR-939-3p inhibitor. Additionally, miR-939-3p was upregulated in sarcoma tissues and cells, correlating with a poor prognosis of sarcoma patients. Moreover, miR-939-3p overexpression suppressed sarcoma cell proliferation, which was significantly attenuated by the restoration of BATF2, while siRNA-mediated knockdown of BATF2 aggravated the miR-939-3p-induced promotion of sarcoma cell proliferation. Further computational algorithms and dual-luciferase reporter assays demonstrated that miR-939-3p repressed BATF2 expression via directly binding to its 3’ untranslated region (3’ UTR).

Conclusion

Collectively, these findings identified miR-939-3p as a novel regulator of BATF2, as well as a prognostic biomarker in sarcoma, and revealed that suppressing miR-939-3p or inducing BATF2 expression may serve as a promising therapeutic strategy against sarcoma.
Numerical simulation of droplet dispersion within meso-porous membranes
Authors: Kyrloglou Apostolos , Giefer Patrick , Fritsching Udo
Published: February 2024

Analysis of membrane processes in fluid processing, and their main influencing operating conditions are relevant in a variety of industrial applications. Increasing regulatory scrutiny and environmental considerations are forcing industries across all sectors, from food and pharma to oil and gas, to further understand and optimise the handling and formulation of liquid systems for efficient process design. In a generic setup for emulsification and liquid formulation the flow and dispersion behaviour of a liquid oil droplet on its way through a porous water filled membrane is analysed. A set of high-resolution numerical simulations of a single oil droplet dispersed in water through a porous membrane structure with varying contact angles is performed. In this work cluster analysis of volume-of-fluid simulation results to obtain statistical droplet size distributions is conducted and further analysed to highlight the effect of the contact angle as well as pressure drop on the dynamics of the system. It is observed that based on the membrane surface activity the droplet behaviour changes from filtration with coalescence when the membrane is lipophilic to emulsification with droplet break-up when the membrane is lipophobic. Furthermore, the pressure drop is identified as a key factor for the dynamics of the droplet process and the frame in which it occurs. These results highlight that the membrane wettability is a determining factor for the emulsification or filtration effectiveness of a membrane for various applications.
Magnetic properties of Fe intercalation FexTaSe2
Authors: Feng Qian-Qian , Guo Jun-Jie , Zhong Mian-Zeng , Luo Zi-Yan , Li Bo , Wang Xi-Guang , Nie Yao-Zhuang , Xia Qing-Lin , Guo Guang-Hua
Published: February 2024

Intercalation of transition metal dichalcogenides with magnetic elements has been the subject of increasing research interest, aiming to explore novel magnetic materials with anisotropy and spin-orbit coupling. In this paper, two magnetic samples with varying Fe content have been prepared using different growth conditions via the chemical vapor transport method. A comprehensive investigation of the magnetic properties of the materials has been conducted using the Physical Property Measurement System (PPMS, EvercoolⅡ-9T, Quantum Design). The results reveal distinct features in the studied materials. Fe0.12TaSe2 exhibits significant ferromagnetism with a Curie transition temperature of 50 K. However, its in-plane magnetism is weak and no significant hysteresis loop is observed below the Curie temperature. On the other hand, Fe0.25TaSe2 exhibits antiferromagnetism without any hysteresis loop and has a Néel temperature up to 130 K. This finding is quite different from the intercalated iron in FexTaS2, where only an antiferromagnetic state occurs with x larger than 0.4. Our study thus provides updated insights into the magnetic properties of this new system and serves as a reference for future investigations of TaSe2 compounds with varying iron content.
An observational study ascertaining the prevalence of bullae and blebs in young, healthy adults and its possible implications for scuba diving
Authors: Bresser Max F. , Wingelaar Thijs T. , Van Weering Jaap A. F. , Bresser Paul , Van Hulst Rob A.
Published: February 2024

Introduction: Intrapulmonary air-filled cavities, e.g., bullae, blebs, and cysts, are believed to contribute topulmonary barotrauma (PBT) and arterial gas embolism (AGE) in divers. However, literature is unclear about the prevalence of bullae in healthy adults, ranging from 2.3—33.8%. While this could in part be explained due to increasing quality of radiologic imaging, such as computed tomography (CT) scans, other methodological factors may also affect these findings. This study aims to ascertain the prevalence of bullae in young and healthy adults.

Methods: This single-center cross-sectional observational study re-assessed the CT scans of adults (aged 18—40) performed for a clinical suspicion for pulmonary embolism, from 1 January 2016 to 1 March 2020. Presence of bullae was recorded in an electronic database. Chi-square and Fisher exact tests were used for statistical analyses. Additionally, a multivariate logistic regression analysis was performed to study the independent predictive value of identified risk factors.

Results: A total of 1,014 cases were identified, of which 836 could be included. Distribution amongst age groups (18–25, 26–30, 31–35, and 36–40) was almost equally, however, 75% of the population was female. Of the male proportion, 41% smoked, compared to 27% in females. In 7.2% (95% CI 5.6–9.1) bullae were identified. The prevalence increased with increasing age (p < 0.001), with odd ratios up to 5.347 (95% CI 2.164–13.213, p < 0.001) in the oldest age group. Males and smokers had higher odds ratios for bullae of 2.460 (95% CI 1.144–4.208; p = 0.001) and 3.406 (95% CI 1.878–6.157, p < 0.001), respectively. Similar results were seen in the multivariate logistic regression analysis, where age, male sex and smoking were all statistically significant independent risk factors for bullae.

Discussion: Bullae were seen in 7.2% of a healthy population up to 40 years old. Increasing age, smoking, and being male were identified as statistically significant risk factors, both in independent and in multivariate logistic regression analyses. Our observations may warrant a re-evaluation of the contribution of bullae to PBT and AGE, as the latter two occur very rarely and bullae appear to be more frequently present than earlier assumed.
Cultural adaptation and psychometric properties of the online learning climate scale for Chilean university students
Authors: Bravo-Sanzana Mónica , Miranda Rafael , Terán-Mendoza Oscar , Mieres-Chacaltana Manuel , Carabantes Luis
Published: February 2024

Introduction

The COVID-19 pandemic has profoundly changed university teaching and learning formats, leading to a significant increase in online learning. Consequently, the crisis has facilitated the potential development of this educational modality. However, researchers need adapted and validated instruments to assess the online learning climate in universities.

Aim

This study aimed to adapt and psychometrically validate the Online Learning Climate Scale (OLCS) for Chilean university students.

Method

Quantitative research was conducted with a non-experimental and cross-sectional, design executed in two phases: the first was oriented to the cultural adaptation of the instrument, and the second was focused on analyzing its psychometric properties in a sample of 491 university students.

Results

A translated and culturally adapted version was obtained, composed of 15 items distributed in a factorial structure composed of four dimensions that showed excellent adjustment to the data [χ2 (84) = 189.628; p < 0.001; CFI = 0.979; TLI = 0.973; RMSEA = 0.051 (IC90% 0.044–0.059); SRMR = 0.028]; internal consistency was estimated through Cronbach’s alpha and ranged between 0.892 and 0.955, and strict invariance between men and women was achieved.

Discussion

The Online Learning Climate Scale (OLCS) is a valid and reliable measure for measuring the online learning climate within the Chilean higher education context so that it can be used both in research and in monitoring management programs in educational environments.
Work stress, work-family conflict, and psychological distress among resort employees: a JD-R model and spillover theory perspectives
Authors: Abdou Ahmed Hassan , El-Amin Maha Abdul-Moniem Mohammed , Mohammed Elham Farouq Ali , Alboray Hanem Mostafa Mohamed , Refai Aza Mohamed Sediek , Almakhayitah Muhanna Yousef , Albohnayh Abdullah Saleh Mohammed , Alismail Abdulaziz Mohammed , Almulla Mazen Omar , Alsaqer Jawharah Saleh , Mahmoud Maha Hassanein , Elshazly Adel Ibrahim Abdullah , Allam Sahar Farouk Abdelgaed
Published: February 2024

The hospitality industry is well-known for its challenging and high-pressure work settings. In this context, employees commonly face a multitude of stressors originating from their roles and job responsibilities, which can significantly impact their psychological wellbeing. Hence, based on the job demands-resources (JD-R) model and the spillover theory, this study aims to empirically explore the direct and indirect effect of work stress (assessed by role overload, ambiguity, and conflict) on psychological distress among frontline employees in 3- and 4-star Egyptian resorts while considering the mediating influence of work-family conflict (WFC). Four hypotheses were put to the test through the application of the PLS-SEM 4.0 version (4.0.9.9). Based on the findings from 563 frontline employees who participated in this research, the study supports the four hypotheses affirming that work-related stressors significantly contributed to employees' psychological distress. Further, the findings highlighted that these stressors significantly spill over into employees' family lives, generating conflicts between work and family roles. In addition, the results emphasized the significance of WFC as a contributing factor to employees' psychological distress. Finally, the study concluded that WFC partially mediates the link between work stress and employees' psychological distress. Based on these findings, some theoretical and practical implications for hospitality scholars, resort management, and policymakers were suggested to enhance the employees' wellbeing and mitigate psychological distress in this vital sector.
Prevalence of somatic diseases in adults with attention deficit hyperactivity disorder in Japan is highest in people aged ≥40 years with mental disorders: a cross-sectional study of a Japanese health insurance claims database
Authors: Takaesu Yoshikazu , Sato Yumi , Iwata Shinpei , Takizawa Patcharapim , Miyauchi Hideyuki , Ishimoto Yoshikazu , Kondo Tsuyoshi
Published: February 2024

Introduction

Studies have reported an association between attention deficit hyperactivity disorder (ADHD) and somatic diseases; however, the correlation of mental disorders with the association between ADHD and somatic diseases remains uninvestigated. This study investigated and compared the prevalence of somatic diseases among adults with/without ADHD, stratified by the presence or absence of mental disorders.

Methods

This cross-sectional study (October 2020–September 2021), using data (June 2013–September 2021) from a Japanese health insurance claims database, included adult participants with a medical record of and receiving medication for ADHD (ADHD group); the control group (matched 1:5 by age/sex) comprised participants without ADHD. The prevalence and odds ratio (OR; ADHD versus control) of type 2 diabetes mellitus (T2DM), diabetes complications, hypertension, cardiovascular disease (CVD), dyslipidemia, gout and hyperuricemia, chronic obstructive pulmonary disease (COPD), non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH), and atopic dermatitis were investigated. Pooled ORs for stratified analysis were calculated using the Mantel-Haenszel method.

Results

In the matched analysis sets, the ORs for all somatic diseases were significantly higher for the ADHD group (n=15,028) versus the control group (n=74,796). On stratified analysis, the Mantel-Haenszel ORs were significant for NAFLD/NASH (1.53; 95% confidence interval [CI]: 1.34, 1.73), diabetes complications (1.39; 95% CI: 1.09, 1.77), and gout and hyperuricemia (1.34; 95% CI: 1.19, 1.51). Furthermore, the stratum-specific ORs for T2DM, hypertension, and dyslipidemia were >1 and <1 in the presence and absence of mental disorders, respectively. The prevalence of all somatic diseases except atopic dermatitis increased with age. For participants aged ≥40 years, the Mantel-Haenszel ORs were significant for all somatic diseases except CVD, COPD, and atopic dermatitis.

Conclusions

The prevalence of several somatic diseases, including chronic disorders, was high among adults with ADHD, particularly in those aged ≥40 years and those with mental disorders.