bluuebunny/crossref_metadata_2025 huggingface dataset:
The place and role of the judiciary in the system of state authorities: implementation of the principle of people’s power
Authors: Byelov D. , Придачук O.
Published: June 2023

The place and role of the judiciary in the system of state authorities: implementation of the principle of people’s power.

The article is devoted to highlighting certain features of the organization and activities of state authorities in Ukraine. The author focuses his attention on the role and place of the judiciary in the mechanism of checks and balances. Separate principles of the construction of the system of judicial power in Ukraine are considered.

It is indicated that a just law is the embodiment of the idea of equal freedom for all - to do everything that does not limit the freedom of others and does not cause harm, as well as what is not prohibited by law. The idea of justice is implemented primarily through the normative consolidation of the right to a fair trial. This right is established both at the national and international levels. Given the closeness of the concepts of «law» and «justice», in the process of consideration of a court case there is a search for the right, and the result of this consideration is embodied in a concrete decision of the court.

The authors note: 1) guaranteed rights (opportunities to perform certain actions) of a person who is a citizen of a specific state should be established by laws. Laws establishing rights, establishing specific obligations and sanctions for non-fulfilment apply equally to all citizens. 2) in order to implement the principle of «the best order» it is necessary to create a logical relationship between coercion and protection in the person of the citizen. This means the following: a citizen must have a real possibility of forcing state and other bodies, third parties to properly comply with the law, just as the state has the possibility of forcing citizens to obey the law. The social nature of the judiciary consists precisely in the resolution by judges (from the standpoint of justice) of conflicts of conflicting interests in society. The solution to the legal nature of judicial power lies in the fact that judges in a specific case demarcate the free spheres of the disputing parties and formulate the corresponding universally binding consequences. The constitutional and legal parameters of ensuring the human rights function of the judiciary are due to the fact that the judiciary itself is a sub-function of a more general concept - the law enforcement function of the judiciary. The current legislation of Ukraine establishes the unity of the judicial system of our country, but in fact this issue is not so obvious due to the existence of organizationally independent and procedurally independent systems of courts of general jurisdiction, economic and administrative courts, as well as the Constitutional Court of Ukraine. However, the general duty of courts to protect the rights and freedoms of a person and а citizen acts as the main constitutional goal of justice - it unites all branches of the judicial power according to their social purpose in the system of state authorities.
Noninstitutionalized international security alliances: safeguarding world peace and regional stability
Authors: Horovenko S.
Published: June 2023

The article summarizes the Ukrainian diplomatic’ success stories in launching non-conventional modalities, instruments, methods of cooperation with global actors aimed to protect fundamental human rights and maintains the grounds for the present international order and stability.

The constructions, instruments and methods in question are peculiar security alliances that encourage intergovernmental cooperation, first of all, in the case of international human rights protection and deepening political, economic, cultural and education diplomacy.

The author produces a personal description of the noninstitutionalized security alliances and provides evidence-based examples of the permanent efficiency of such partnerships. The author pays attention to examining noninstitutionalized intergovernmental cooperation to clearly understand the security status quo in Europe and the world.

Although most classic international organizations informally support Ukraine in its military defense against russia, there are no factual perspectives to formalize this cooperation, such as NATO or EU integration, in the nearest future. The author illustrates the dualistic nature of noninstitutionalized international security alliances. On the one hand, they support fundamental regional actors such as NATO and the EU to execute their policy without formal promises or official bunding upon Ukraine. From another hand, it assists Ukraine in integrating state policy into the NATO and EU agenda and structure. Thus it brings Ukraine closer to Euro-Atlantic and European integration implicitly with both separate EU and NATO member states and such organizations as a whole.

Eventually, the democratic states practice establishing and maintaining international cooperation in extraordinary security alliances as alternatives to classic international relations to ensure regional security and global peace. Ukrainian experience based on the full-scale international armed conflict is an excellent case to examine and further research.
Segregación laboral de las mujeres profesionales por motivos de género en Ecuador
Authors: Pila Guzmán Paola Viviana , Déleg Guazha Nancy Rosario
Published: June 2023

La segregación laboral analiza las condiciones de las mujeres en el mundo del trabajo. Con base en la teoría feminista sobre segregación horizontal y vertical, se analizaron datos de la Encuesta Nacional de Empleo, Desempleo y Subempleo generada por el Instituto Nacional de Estadística y Censos, 2019 y 2020. Como resultado, se encontró segregación horizontal a partir de ramas feminizadas y masculinizadas; y segregación vertical debido al mayor nivel de participación de hombres profesionales en cargos de dirección y gerencia, y de las mujeres profesionales en el nivel de apoyo administrativo; revelando la situación a la que se enfrentan las mujeres dentro del mercado laboral ecuatoriano y que ha sido impactada de manera significativa por la crisis del COVID-19.
Conquista y pérdida de Yucatán: la arqueo­logía estadounidense en el área maya y el Estado nacional mexicano, 1875-1940. Libro de Guillermo Palacios
Authors: Escalona Victoria José Luis
Published: June 2023

El libro de Guillermo Palacios, Conquista y pérdida de Yucatán, nos acerca a un período de la historia moderna de Chichén Itzá, entre las últimas décadas del siglo XIX y el inicio del siglo XX. En la exploración del sitio arqueológico se cruzan a su vez las historias del surgimiento de la arqueología americana, la formación del “área maya”, la reformulación de las regulaciones estatales sobre el pasado y los bienes de la nación, y los antecedentes del turismo.
The Early Poetry of Nikos Engonopoulos: Aspects of the Embodiment of Imagery
Authors:   Lomonosov Moscow State University, Vasina Daria
Published: June 2023

The article is devoted to the imagery in the first two poetry books “Do Not Distract the Driver” and “The Clavichords of Silence” by Nikos Engonopoulos, one of the brightest representatives of Greek surrealism. In his early works, the poet follows surrealist principles, the main of which is the principle of building paradoxical, illogical connections between ordinary objects. With the help of such connections it is considered possible to comprehend surreality. At the same time, the absurdity of images is not tantamount to incomprehensibility: their repetitions and use in various contexts made it possible to single out several key images and offer their interpretation in this article.
On the Individual Author’s Meaning of the Lexeme “reverence” [blagogovenie] in the Russian Literary Language of the 17th century: Supplement to the Historical Dictionary
Authors:   Lomonosov Moscow State University, Nikolenkova Natalia
Published: June 2023

The article considers the formation of the individual author’s meaning of the lexeme “reverence” in the academic register of the Church Slavonic language of the second half of the 17th century. This register is characterized by an attitude towards language as an object of modeling, which in many ways determines the search by Epiphany Slavinetsky and Arseniy Satanovsky, translators of the text, for different translation strategies. In this case, the authors use the technique of creating a new meaning for a lexeme already existing in the linguistic arsenal – a technique that the tradition of describing the history of vocabulary allocates only for the language of the next century.
Effectiveness of Video-assisted Teaching Programme on Knowledge regarding Breast Self-examination among BSc Nursing 2ndYear Students of MMINSR, SKIMS, Soura
Authors:   Mader-e-Meharban, Institute of Nursing Sciences and Research, SKIMS, Soura, Srinagar, Jammu and Kashmir, India, Kumari Diksha
Published: June 2023

Background: The goal of breast self-examinationfor women is to notice changes in the breast thatshould be broughttothe attentionof physiciansforfurtherevaluation. Theseincludebreast lumps, changes in breast shape, size, or contour, and colour of breast and nipple. Objectives: To assess the pre-test and post-test knowledge level regarding breast self-examination among BSc Nursing 2ndyear students of MMINSR, SKIMS, Soura, to compare pre-test and post-test knowledge scores regardingbreast self-examination among BSc Nursing 2ndyear students of MMINSR, SKIMS, Soura,and to determine the association of pre-test knowledge scores regarding breast self-examination among BSc Nursing 2ndyear students with selected demographical variables. Methodology: Pre-experimental one-group pre-test post-test design was used. The setting chosen for the present study was MMINSR, SKIMS, Soura, Srinagar, Kashmir. The current study included 50 BSc Nursing 2ndyear students selectedby purposive sampling technique. A self-structured questionnaire was used. Results: The pre-test showed that 62% of participants had moderate knowledge, 38% had inadequate knowledge, and none of the subjectshad adequate knowledge. The post-test revealed that 86% had adequate knowledge, 14% had moderate knowledge, and none of the study subjects had inadequate knowledge. Conclusion:Pre-test findings concluded that the studysubjectshadmoderateknowledgeregarding breast self-examination. So, there was a need to make them aware by educating them regarding breast self-examination.
Conceptual Study of Srotas (Body Channels) & Medicinal Plants Acting on Them
Authors:   Principal, Govt. Ayurveda, Yoga & Prakrut Chikitsa Mahavidhyalaya, Jaipur, Rajasthan, India, Kaushal Kamini
Published: June 2023

Srotas (body channels) are said to be a significant component of the body and are in responsible of Vahana (transferring) Dosha, Dhatu, etc. Srotomaya (made of Srotas) is regarded as the full body. These Srotas have strong ties to each individual moolasthana. Due to their involvement in the development, inspection, and regulation of the Bhavapadartha flowing through the Srotas, these Moolsthana are crucial from a therapeutic and prognosis perspective. Srotas nourishes the body, keeps the digestive and metabolic processes in balance, and restores the cleansing process. Disturbances in the transportation process are among the anomalies in Srotas. Clinically calming Srotasvitiation can be used to manage pathological disorders linked to anomalies in Srotas. The concept of Srotas is explained in this article in light of ayurvedic principles.
A proposed quantitative method for assessing the impact of river regulation on its hydromorphological status
Authors: Kiraga Marta J. , Markiewicz Anna
Published: June 2023

Changes in river channel morphological parameters are influenced by anthropogenic factors, such as climatic changes, river catchment management changes, and hydrotechnical development of rivers. To assess the intensity of individual pressures and the resulting changes in abiotic and biotic factors in the riverbed, water quality monitoring is conducted, including the assessment of the hydromorphological status. The assessment can be based on the River Habitat Survey (RHS) which is a synthetic method that includes the evaluation of habitat character and river quality based on their morphological structure. The input data, which characterise any river include physical features of hydrotechnical structures, bed granulation, occurrence of bedforms, visible morphodynamic phenomena, and a sediment transport pattern. The RHS method allows to determine two quantitative indices used to evaluate the hydromorphological status: Habitat Modification Score ( HMS), which determines the extent of transformation in the morphology of a watercourse, and Habitat Quality Assessment ( HQA), which is based on the presence and diversity of natural elements in a watercourse and river valley. The proposed method can be divided into three stages. The first assesses the river section hydromorphological indices, describing the degree of technical modification ( HMS) and the ecological quality of the reach ( HQA), using the RHS method. The second stage describes morphological changes resulting from the technical regulation and estimates indices for the regulated reach. Finally, we compare HQA and HMS indices before and after the regulation. This comparison is described by numerical indicators and related to reference values.
Impact of land use and land cover changes on carbon stock in Aceh Besar District, Aceh, Indonesia
Authors: Achmad Ashfa , Ramli Ichwana , Nizamuddin Nizamuddin
Published: June 2023

The international community affirms the critical role of forests in climate change mitigation, which includes reducing emissions from degradation and deforestation, carbon stock conservation, sustainable forest management, and increasing carbon stocks in developing countries. It relates to land use and land cover changes. This study aims to review land use and land cover changes (LULC) in two decades, namely 2000–2010 and 2010–2020, and the impact on carbon stocks. Landsat satellite imagery in 2000, 2010, and 2020 are classified into six categories: built-up area, cropland, forest, water body, bareland, and grassland. This classification uses supervised classification. The accuracy kappa coefficient values obtained for the LULC 2000, LULC 2010, and LULC 2020 maps were 89.61%, 83.90%, and 87.10%, respectively. The most dominant systematic LULC change processes were forest degradation in 2000–2020; the transition of forest to cropland (349.20 ha), forest to bareland (171.19 ha), and forest to built-up area (661.68 ha). Loss of using the forest for other uses was followed by a decrease in carbon stock. There was a high decrease in carbon stock in the forest category (11,000 Mg C∙y–1). The results showed a significant change in land use and cover. The decline in the area occurred in the forest category, which decreased from year to year. Meanwhile, the built-up area increases every year. Carbon stocks also decrease from year to year, especially forests as the most significant carbon store, decreasing in the area.
Proteção ao princípio da laicidade no ordenamento jurídico brasileiro
Authors: Maciel Pinheiro Pereira Carlos André , Dos Santos Mesquita Mirlâine
Published: June 2023

O presente artigo tem como objetivo analisar o princípio da laicidade presente no ordenamento jurídico vigente com ênfase na necessidade de proteger a laicidade por ser ela um instrumento capaz de promover o tratamento isonômico determinado pelo art. 5º, caput, da Constituição Federal e também um meio de pacificação de conflitos existentes entre a seara religiosa e o Estado. A relevância do tema abordado consiste no fato de ser a laicidade um assunto que envolve a efetivação de direitos fundamentais, como a liberdade de crença e consciência. Ademais, no tocante a essa problemática, as discussões carecem de aprofundamento, uma vez que ainda não há uma resposta social satisfatória para as controvérsias existentes entre as religiões e o Estado. O estudo se desenvolve, inicialmente, buscando contextualizar a origem da laicidade e sua delimitação jurídica; posteriormente, enfatiza a liberdade de crença e consciência enquanto um direito fundamental e as limitações concernentes a esse direito e, por fim, analisa a eficácia vertical da liberdade de crença versando ainda sobre seus conflitos com o Estado laico e as possíveis formas de solucioná-los. Nessa perspectiva, o método utilizado será o dedutivo e dialético; associado a uma pesquisa qualitativa, tendo em vista que partirá de uma análise acerca de como surgiu a laicidade, perpassando seu contexto jurídico e finalmente demonstrando suas implicações práticas. Portanto, tal pesquisa se faz pertinente, pois é de suma importância buscar soluções efetivas para os conflitos sociais de uma sociedade plural na qual a secularização se faz presente.
“CPF cancelado”
Authors: Grischke Lucas Lopes
Published: June 2023

O presente trabalho, com foco na transmissão televisiva de jornais policiais, tem por objetivo a tentativa de promover uma análise se o espaço midiático, reforça ou fomenta os comportamentos excludentes de correntes políticas alicerçadas em ações de ódio e em descaso aos Direitos Humanos. A estrutura do trabalho se divide em três tópicos. No primeiro, apresenta-se, dentro do conceito de sensacionalismo, entre outros aspectos, o formato do telejornal “policialesco”, a atuação do apresentador, a linguagem utilizada e direcionada à telespectadora e ao telespectador. Em seguida, o tópico “Sensacionalismo midiático e aproximações ao discurso fascista: os Direitos Humanos violados” realiza o enfoque no discurso difundido nestes telejornais que reiteradamente violam os Direitos Humanos. Com base nas opiniões contundentes emitidas nas programações policiais, esboça-se, então, um entrelaçamento destas com os elementos do movimento fascista. Finalmente, o terceiro tópico propõe a utilização da Educação em Direitos Humanos, aliada à relevância da mídia como uma das alternativas para combate ao avanço do neofascismo no Brasil. A perspectiva teórica-metodológica deste trabalho se baseia em análise bibliográfica sobre temas como “sensacionalismo midiático” (JÚNIOR, 2016; NEGRINI, 2008; VARJÃO, 2015; ZEILMANN, 2021), “fascismo” (DORNELLES, 2017; LIMA, 2018; LÖWY, 2021), “Direitos Humanos” (FURLANI, 2009; SANTOS, 2013), “educação em Direitos Humanos” (DIAS; BRUM, 2017; DIBBERN; CRISTOFOLETTI, 2017). É importante refletir quanto aos limites da liberdade de expressão de canais televisivos, uma vez que são concessões públicas, quando descumprem os preceitos legais de criação e funcionamento e consentem em infrações que lesionam e afrontam a Constituição Federal e tratados internacionais.
A imunidade recíproca e a tributação das subvenções governamentais
Authors: Tavares Della Valentina Vitória
Published: June 2023

A presente pesquisa tem como objetivo analisar a constitucionalidade da fixação de requisitos legais para classificação dos incentivos fiscais de ICMS concedidos pelos Estados-membros como subvenções governamentais e, por consequência, excluir tais verbas do lucro real para fins de tributação, frente à imunidade recíproca. Partindo-se da abordagem hipotético-dedutiva, este estudo, de natureza qualitativa, foi desenvolvido por meio de procedimento bibliográfico, com base na doutrina nacional, explorando-se os conceitos de imunidade recíproca, de subvenções governamentais e o limite da legislação infraconstitucional perante o texto constitucional, bem como o arcabouço legislativo pertinente. Ao final, conclui-se que a fixação, por meio de lei ordinária, convalidada por lei complementar, de requisitos para afastar a tributação de IRPJ e da CSLL sobre as subvenções governamentais concedidas pelos Estados-membros da federação viola a imunidade recíproca, pois culmina na restrição do conteúdo constitucional da imunidade e, por consequência, admite a tributação de verbas provenientes dos Estados-membros concedidas aos contribuintes com o objetivo de desenvolvimento regional.
Os destinatários do Direito à imagem e a gradação biológica
Authors: Bretas Hugo Rios
Published: June 2023

O Direito à imagem carece de uma análise sistêmica, gravitando sobres as searas constitucionais e infraconstitucionais, nesse condão, há um encontro hermenêutico entre a imagem, dignidade, honra e personalidade, tendo em vista as características e os princípios. O fato é que a imagem tem sido objeto de profunda revisitação nos ambientes dogmáticos, jurisprudenciais e teóricos, bem como tem havido intensa revisitação do inafastável princípio da dignidade da pessoa humana, comumente em razão de discursos pluralistas e eudemonistas. Não há mais um abismo entre as pessoas naturais, pessoas jurídicas e entes despersonalizados, todavia, apesar de certas aproximações, não é prudente a promoção de rupturas teóricas e práticas absolutas entre estes destinatários. Sabido é que o ponto nevrálgico diferenciador entre as pessoas jurídicas e naturais, não obstante a intensidade da teoria realista, sempre será a dignidade da pessoa humana. Ao longo deste artigo, os interlocutores poderão acompanhar os panoramas, jurisprudencial e teórico, que se alastram nos átrios do Direito brasileiro, ensejando um movimento expansionista protetivo do discurso da imagem, revelando tendencialmente que os danos morais poderão se configurar em razão da violação dos direitos à personalidade ou à imagem. Ao longo do artigo também inquietaremos o autor para perspectivas como: É possível ter direito à imagem sem ter personalidade? Pode haver a configuração da indenização por danos morais em favor daquele desprovido de personalidade? Diante disso, a partir de uma visão hermeneuticamente crítica, tentarei minimamente harmonizar essas questões.
Diálogo entre a Corte Europeia e a Corte Interamericana de Direito Humanos
Authors: Rosa e Silva Tulio Macedo , Ribeiro Adriano Cezar , Martins Rocha Pereira Angela Angeline , Chirino colina Juan Alcides
Published: June 2023

A defesa e a promoção dos Direitos Humanos são desempenhadas em âmbito internacional por uma rede de instituições criadas para essas finalidades, como, por exemplo, os órgãos do sistema interamericano e os do sistema europeu de proteção aos direitos humanos, cada um com sua própria origem, história, conjunto de normas e mecanismos, o que inclui a função judicial autônoma, independente, com competência contenciosa e consultiva. Nesse contexto, os direitos humanos possuem como características a universalidade, a indivisibilidade, a interdependência e a interrelação, atributos que podem ser verificados por meio da análise do diálogo entre as Cortes Americana e Europeia de Direitos Humanos em suas jurisprudências e costumes, remetendo ao mesmo propósito final de garantia e implementação dos direitos humanos.
A formação continuada de servidores do Tribunal de Justiça de Pernambuco
Authors: Torres Adleiton da Silva , Cardoso Fernando da Silva
Published: June 2023

Refletimos neste estudo sobre a relação entre a dinâmica interna do Poder Judiciário de Pernambuco e a formação continuada do(a) servidor(a) enquanto díade para compreender a circulação do capital simbólico entre diferentes atores do órgão. Assim, os objetivos específicos do estudo são: compreender as raízes da cultura organizacional do Tribunal de Justiça de Pernambuco; refletir acerca da gestão administrativa do judiciário pernambucano; relacionar a dinâmica de precarização da formação profissional do(a) trabalhador(a) do judiciário pernambucano em relação à cultura organizacional do TJPE. Metodologicamente, trata-se de uma abordagem quali-quantitativa que apresenta a análise de relatórios oficiais bem como a sistematização e consulta de dados referentes à capacitação profissional de servidores(a) lotados no Fórum da Comarca de Arcoverde. Os dados obtidos descortinam que políticas de formação continuada geridas a partir de ditames neoliberais, preocupadas com indicadores que com a construção de um ambiente colaborativo, as quais não conduzem respostas satisfatórias diante dos desafios e da complexidade social com a qual lida o órgão.
Identifikasi Senyawa Aktif Pala (Myristica fragrans) sebagai Terapi Komplementer Antihipertensi melalui Penghambatan Reseptor ACE: Sebuah Studi Penambatan Molekuler
Authors: Romadhan Muhammad Despriansyah , Afladhanti Putri Mahirah , Gayatri Ni Made Dyah
Published: June 2023

Hipertensi merupakan salah satu masalah kesehatan terbesar yang menjadi penyebab utama kematian di seluruh dunia. Angiotensin converting enzyme inhibitor (ACE-I) sebagai obat antihipertensi yang umum diketahui memiliki efek samping yang sering dikeluhkan. Penelitian ini bertujuan untuk mengidentifikasi senyawa potensial yang berasal dari pala (Myristica fragrans) sebagai antihipertensi dengan menggunakan studi penambatan molekular. Dua puluh tiga senyawa pala bersama dengan captopril digunakan dalam penelitian ini melalui pencarian literatur dan penyaringan daring. Senyawa dan obat pembanding diunduh melalui PubChem sementara reseptor target pada pada RCSB. Swiss ADME, ProTox-II, dan admetLab digunakan untuk mengevaluasi senyawa mirip obat dan memprediksi toksisitas senyawa. Senyawa dan captopril dilakukan penambatan molekular pada reseptor target ACE menggunakan Autodock tools 1.5.6 dan Autodock Vina serta visualisasi interaksi molekul dengan aplikasi Discovery Studio v16. Hasil penelitian menunjukkan seluruh senyawa memenuhi kriteria sebagai obat dan memiliki afinitas terhadap ACE. Catechin, beta-caryophyllene, dan alpha-bergamoten tidak toksik dan menunjukkan interaksi molekul yang kuat pada ACE dibanding dengan captopril dan senyawa lain dengan energi ikatan masing-masing -8,2, -7,3, -7,2 kkal/mol. Catechin, beta-caryophyllene, dan alpha-bergamoten berpotensi untuk dikembangkan sebagai ACE-I. Penelitian in vitro dan in vivo lebih lanjut diperlukan agar dapat dilakukan uji klinis.
SÍNDROME DE BURNOUT ENTRE PROFISSIONAIS QUE TRABALHAM COM ATENDIMENTO AO PÚBLICO
Authors: De Queiroz Viviane Cordeiro , Delmiro Andrezza Rayana da Costa Alves , De Medeiros Rebeca Cordeiro , Da Silva Jacqueline Barbosa , Costa Sérgio Eduardo Jerônimo , Da Silva Sanzia Lee Plácido
Published: June 2023

Objetivo: Identificar a ocorrência da Síndrome de Burnout nos profissionais que trabalham com atendimento ao público. Método: estudo de corte transversal, descritivo com 81 profissionais de uma faculdade em município brasileiro, entre os meses de setembro e outubro de 2021. Aplicou-se o instrumento validado Maslach Burnout Inventory e um formulário com as caracteristicas sociodemográficas. Resultados: A maioria dos entrevistados tem entre 18 e 30 anos, se auto declaram pardos e possuem ensino superior. Observou-se que 45% dos participantes tem uma possibilidade de desenvolvimento da sindrome, e 38% estão na fase inicial. Conclusão: profissionais mais jovens são mais propensos a apresentar a síndrome de Burnout. Estimula-se o desenvolvimento de estudos interdisciplinares para o processo saúde-doença-mental possibilitando uma nova abordagem de preveção e cuidado em condutas investigativas e intervencionistas em academias de níveis superiores, de forma a buscar momentos saudáveis para o profissional.
Thrombosed orbital varix of the inferior ophthalmic vein: A rare cause of acute unilateral proptosis
Authors: Abdelsalam Ahmed , Ramsay Ian A. , Ehiemua Uche , Thompson John W. , Fountain Hayes B. , Eatz Tiffany , Wu Eva M. , Bhatia Rita G. , Lam Byron L. , Tse David T. , Starke Robert M.
Published: June 2023

Background:

Orbital varices are rare, accounting for only 0–1.3% of orbital masses. They can be found incidentally or cause mild to serious sequelae, including hemorrhage and optic nerve compression.

Case Description:

We report a case of a 74-year-old male with progressively painful unilateral proptosis. Imaging revealed the presence of an orbital mass compatible with a thrombosed orbital varix of the inferior ophthalmic vein in the left inferior intraconal space. The patient was medically managed. On a follow-up outpatient clinic visit, he demonstrated remarkable clinical recovery and denied experiencing any symptoms. Follow-up computed tomography scan showed a stable mass with decreased proptosis in the left orbit consistent with the previously diagnosed orbital varix. One-year follow-up orbital magnetic resonance imaging without contrast showed slight increase in the intraconal mass.

Conclusion:

An orbital varix may present with mild to severe symptoms and management, depending on case severity, ranges from medical treatment to escalated surgical innervation. Our case is one of few progressive unilateral proptosis caused by a thrombosed varix of the inferior ophthalmic vein described in the literature. We encourage further investigation into the causes and epidemiology of orbital varices.
Dynamic asymmetry in cerebrospinal fluid pressure: An indicator of regional differences in compliance
Authors: English Connor J. , Taylor Zachary , Cramberg Michael , Young Bruce A.
Published: June 2023

Background:

Dural compliance influences the shape and magnitude of the cerebrospinal fluid (CSF) pulsations. In humans, cranial compliance is approximately 2× greater than spinal compliance; the differential has been attributed to the associated vasculature. In alligators, the spinal cord is surrounded by a large venous sinus, which suggests that the spinal compartment may have higher compliance than is found in mammals.

Methods:

Pressure catheters were surgically implanted into the cranial and spinal subdural spaces of eight subadult American alligators (Alligator mississippiensis). The CSF was propelled through the subdural space by orthostatic gradients and rapid changes in linear acceleration.

Results:

CSF pressure recordings taken from the cranial compartment were consistently, and significantly, larger than those taken from the spinal compartment. After the myodural bridge of Alligator was surgically released, the asymmetry in CSF pressure was decreased.

Conclusion:

Unlike the situation in humans, the spinal compartment of Alligator has greater compliance than the cranial compartment, presumably due to the presence of the large spinal venous sinus surrounding the dura. The change in CSF pressures after myodural surgical release supports the hypothesis that the myodural bridge functions, at least in part, to modulate dural compliance and the exchange of CSF between the cranial and spinal compartments.
Pancreatic Panniculitis Secondary to Pancreatic Cyst With Lower Extremity Wounds as a Primary Presenting Feature: A Case Report and Literature Review
Authors: Fang Lauren , Simman Richard , Ayoub Samar , Chompunut Assava-Aree
Published: June 2023

Introduction. Pancreatic panniculitis is a rare skin manifestation of pancreatic disease. It is characterized by inflammation and liquefactive necrosis of subcutaneous fat. Treatment involves addressing the underlying cause and providing supportive wound care. Case Report. The authors present a case of a 68-year-old man who developed painful, erythematous wounds on his lower extremities that progressed to purple, edematous lesions with purulent drainage. During the progression of his wounds, he developed epigastric pain and acute pancreatitis. Subsequent CT scan showed a pancreatic cyst that had extended into the portal vein. Deep, excisional biopsy of the wounds helped further narrow the differential. Histology indicated “ghost cells,” which are adipocytes with a central clearing and dark basophilic calcium deposits in the cytoplasm. Conclusion. The presence of ghost adipocytes is a rather unique histopathological feature consistent with pancreatic panniculitis and should be considered in combination with the overall clinical picture to determine the underlying etiology. Pancreatic panniculitis can be a primary presenting feature and possible complication of pancreatic disease.
OPTIMIZATION OF HYPERBARIC ANESTHETIC DOSAGE FOR UNILATERAL SPINAL ANESTHESIA IN ORTHOPEDIC AND TRAUMA OPERATIONS
Authors: KOZLOVSKA IRYNA , DATSYUK OLEKSANDR
Published: June 2023

Topicality. Using generally accepted methods of calculating doses of local anesthetic during spinal anesthesia, the efficiency and safety of anesthesia are not always sufficient.

The aim of our study was to determine the optimal dose of local anesthetic according to the height of the patient gradation method for unilateral and bilateral spinal anesthesia during orthopedic and traumatological operations on the lower extremities. Determine the advantages and disadvantages of both methods of analgesia.

Materials and methods: Our study is based on an examination of 52 patients of I-II degrees of surgical risk according to ASA, divided into two groups. The first group (control) included 25 patients who underwent bilateral spinal anesthesia, the second group included 27 patients who underwent unilateral spinal anesthesia during orthopedic and traumatological operations on the lower extremities. Spinal anesthesia was performed with a hyperbaric solution of 0.5% bupivacaine, with the anesthetic dosing algorithm developed by us.

Results: When evaluating the effectiveness of the performed spinal anesthesia, the duration of sensory and motor blocks and the level of development of sensory blockade by dermatomes in both study groups were determined. In the 1st group, the sensory block was 252.2±74.32 min., the motor block was 198.2±59 min. In the II group, the sensory block was 189.25±34.27 min., the motor block was 154.07±28.59 min. When determining the frequency of cardiovascular complications, dynamics of indicators in mean arterial pressure (MAP) and heart rate (HR) were determined before surgery, after 5 min., 30 min., 1 h., 2 h., 3 h., 5 h., 7 h., 9 h. It was found that the decrease in MAP and heart rate prevailed in the first group during the study. The volume of crystalloid infusion in the first research group was 2042±663.9 ml, and in the second group – 1666.66±635.49 ml. Laboratory diagnostic methods were used in order to determine dynamics of indicators in the basic metabolism and hormonal background during the occurrence of pain syndrome in patients and the effect of the dose of local anesthetic on the speed and level of changes in these parameters. For this purpose, changes in blood glucose, lactate and blood cortisol were determined before surgery, 3 hours, 6 hours and 9 hours of anesthesia course.

Conclusions: 1. Gradational dosing of local anesthetic for unilateral and bilateral spinal anesthesia according to height ensures the necessary effectiveness of analgesia. 2. Reducing the dose of anesthetic during unilateral spinal anesthesia increases the safety of anesthesia and causes less side effects. 3. The duration and level of sensory blockade of unilateral spinal anesthesia is significantly reduced when using a reduced dose of local anesthetic in comparison with bilateral.
Predictive model for dysmenorrhea level in female Taekwondo athletes: Investigating the influence of BMI and micronutrient intake
Authors: Fitrianingsih Asti Dewi Rahayu , Santanu Ayu Mutiara , Novitasari Putri
Published: June 2023

Disturbances during menstruation such as dysmenorrhea affect the performance of female athletes. However, research on the physiologic conditions of female Taekwondo athletes was still very limited. This study aimed to obtain a predictive model for the level of dysmenorrhea and to test which variable had the most influence on the rate of dysmenorrhea. The research design adopted cross-sectional methods. Multiple linear regression analysis was performed to analyze the effect of BMI and micronutrient intake of nine elite regional and national female Taekwondo. The results showed that the average female athlete had a normal BMI, while for micronutrient intake per day, the average intake of vitamin E was low, the vitamin B6 intake was low, Magnesium intake was low and Calcium intake was fulfilled. The most influence on the occurrence of primary dysmenorrhea in female Taekwondo athletes was calcium intake. This study was limited to measurements of BMI and dietary micronutrient intake, which might help provide data that coaches, athlete nutritionists, and athletes could be used to predict and assess the incidence of primary dysmenorrhea. More research could use the Food Frequency Questionnaire (FFQ), which could better explain how often athletes consumed certain food ingredients over a specific time period.
Identifying potential and talented athletes in Tarung Derajat: A psychological perspective test
Authors: Setiawan Ipang , Kurniawan Wahyu Ragil
Published: June 2023

Identifying talented athletes is crucial for coaching and developing athletic talent in sports. Psychology plays a significant role in influencing athletes’ performance therefore it deserves attention in the identification process. This study aimed to identify potential athletes with the best abilities according to Tarung Derajat’s characteristics through a psychological perspective test. The research employs a survey method with a descriptive quantitative analysis approach. The SPQ20 questionnaire was used as the data collection instrument. The results of the psychological test were converted into percentages to determine the athletes’ potential, ranging from very potential to not potential. The research sample consisted of athletes from the training unit in the Semarang City area. The categorization criteria were based on norms derived from the highest-achieving athletes at the national level in Central Java province, with Tarung Derajat being the highest level. The findings indicated the following percentages for the achievement components: 68% for achievement, 66% for competitiveness, 62.9% for managing pressure, 67.78% for self-efficacy, 63.73% for fear of failure control, 63.83% for stress management, 65.56% for emotion, 70.33% for empathy, 54.40% for power, and 67.73% for aggressiveness. Based on a psychological perspective, this research concludes that 50 athletes (64%) in the training unit demonstrate potential as talented athletes. It is important to note that this study was limited to Tarung Derajat athletes in Central Java Province. The research findings contribute to the Central Java Tarung Derajat Training Centre by facilitating the categorization of athletes’ talent based on psychological aspects. Further, researchwas recommended to explore talent and potential of athletes from other perspectives not covered in this study.
Insights into substrate recognition by the unusual nitrating enzyme RufO
Authors: Dratch Benjamin , McWhorter Kirklin , Blue Tamra , Jones Stacey , Horwitz Samantha , Davis Katherine
Published: June 2023

Nitration reactions are crucial for many industrial syntheses; however, current protocols lack site-specificity and employ hazardous chemicals. The non-canonical cytochrome P450 enzymes RufO and TxtE catalyze the only known direct aromatic nitration reactions in nature, making them attractive model systems for the development of analogous biocatalytic and/or biomimetic reactions that proceed under mild conditions. While the associated mechanism has been well characterized in TxtE, much less is known about RufO. Herein, we present the first structure of RufO alongside a series of computational and biochemical studies investigating its unusual reactivity. We demonstrate that free L-tyrosine is not readily accepted as a substrate, despite previous reports to the contrary. Instead, we propose that RufO natively modifies L-tyrosine tethered to the peptidyl carrier protein of a non-ribosomal peptide synthetase encoded by the same biosynthetic gene cluster and present both docking and molecular dynamics simulations consistent with this hypothesis. Our results expand the scope of direct enzymatic nitration reactions and provide the first evidence for such a modification of a peptide synthetase-bound substrate that may aid in the downstream development of biocatalytic approaches to synthesize rufomycin analogs and related drug candidates.
Effect of velocity on the clogging of particles in water-saturated porous media using the CFDDEM
Authors: Sun Dan
Published: June 2023

The clogging of particles in a slurry passing through a porous medium is mainly affected by the ratio of the particle diameter to the pore throat size of the medium. A previous study showed that the Stokes number and the particle concentration affect particle clogging and retention. Therefore, in this study, the effects of fluid velocity on particle clogging were investigated by analyzing the particle transport and retention in a homogeneous porous medium. The fluid-particle two-phase flow in a porous medium was simulated using the computational fluid dynamicsdiscrete element method. The results showed that increasing the fluid velocity of particles such that the Stokes number was almost equal to 1 increased the separation efficiency of particles. Further increasing the fluid velocity reduced the residence time, which reduced the separation efficiency of the particles.
Peptide-conjugated phage-mimicking nanoparticles exhibit potent antibacterial action against Streptococcus pyogenes in murine wound infection models
Authors: Olesk Johanna , Donahue Deborah , Ross Jessica , Sheehan Conor , Bennett Zach , Armknecht Kevin , Kudary Carlie , Hopf Juliane , Ploplis Victoria A. , Castellino Francis J. , Lee Shaun W. , Nallathamby Prakash
Published: June 2023

The development of antibiotic resistance and the resulting emergence of multidrug-resistant bacteria has become one of the main threats in the public health system, commonly leading to nosocomial infections. Many researchers have turned their focus to developing alternative classes of antibacterial systems based on various nanomaterials. We have developed an antibiotic-free nanoparticle system, inspired by naturally occurring bacteriophages, to fight antibiotic-resistant bacteria. Our phage-mimicking nanoparticles (PhaNPs) display structural mimicry of protein-turret distribution on the head structure of bacteriophages. By mimicking phages, we are able to take advantage of their evolutionary constant shape and their high antibacterial activity while avoiding immune reactions of the human body, potentially caused by phages. We describe the synthesis of hierarchically arranged core-shell nanoparticles, with a silica core conjugated with silver-coated gold nanospheres. Improving on our previous design, we have chemisorbed the synthetic antimicrobial peptide Syn-larvacin 71 on the PhaNP surface which further increases the antibacterial activity of the nanoparticles (PhaNP@Syn71). The antibacterial effect of the PhaNP@Syn71 was tested in vitro and in vivo against Streptococcus pyogenes, a causative agent for strep throat, impetigo, and more invasive diseases. In vitro results showed delayed growth as well as inhibition of bacterial growth (up to 99%). Cytocompatibility testing on HaCaT human skin keratinocytes showed minimal cytotoxicity of PhaNP@Syn71, being comparable to the vehicle cytotoxicity levels even at higher concentrations, thus, proving that our design is biocompatible with human cells. Studies on a mouse wound infection model exhibited high biocompatibility in in vivo settings while showing immediate stabilization of the wound infection following the first dose of PhaNP@Syn71. Our results suggest the strong utility of antimicrobial peptide-conjugated phage-mimicking nanoparticles as a highly effective antibacterial system that can combat a clinically relevant bacterial pathogen.
Cell-Penetrating Peptide–Bismuth Bicycles
Authors: Voss Saan , Adair Liam , Achazi Katharina , Kim Heeyoung , Bergemann Silke , Bartenschlager Ralf , New Elizabeth , Rademann Jörg , Nitsche Christoph
Published: June 2023

Cell-penetrating peptides (CPPs) play a significant role in the delivery of cargos into human cells for a wide range of therapeutic and diagnostic applications. We disclose the first CPPs based on peptide–bismuth bicycles, which can be readily obtained from commercially available peptide precursors, making them highly accessible for a wide range of applications. These CPPs enter mammalian cells with high efficiency as demonstrated by live-cell microscopy using fluorescently labelled peptides. We report highly efficient sequences that demonstrate comparable cellular uptake to conventional CPPs, despite requiring only three positive charges. Bicyclization triggered by the presence of bismuth(III) increases cellular uptake by more than one order of magnitude. Through the analysis of cell lysates using inductive coupled plasma mass spectrometry (ICP-MS), we have introduced an alternative approach to examine the cellular uptake of CPPs without the use of fluorescent dyes. This has allowed us to confirm the presence of bismuth in cells after exposure to our CPPs.
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Authors: A Anandh
Published: June 2023

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Synthesis, Characterization and The Effect of the Auxiliary Ligands on the Dimensionality of Two Cobalt(II)-Fumarate Coordination Polymers with Bis(imidazole) Ligands
Authors: Arslan Biçer F. , Yeşilel O.Z.
Published: June 2023

Two new Co(II) coordination polymers, namely {[Co(m-fum)0.5(m-obix)2(H2O)](NO3)}n (1), {[Co(m-fum)0.5(m-mbix)2(H2O)](NO3)}n (2), (H2fum: fumaric acid, obix:1,2-bis(imidazol-1-yl-methyl)benzene, mbix: 1,3-bis(imidazol-1-yl-methyl)benzene), have been successfully synthesized under hydrothermal conditions. They have been structurally characterized by elemental analysis, IR spectra, single crystal X-ray diffraction, powder X-ray diffraction (PXRD), magnetic properties. Single-crystal X-ray analysis reveals that the asymmetric units of both CPs contain a Co(II) ion, half fumarate ligand, two bis(imidazole) ligands, one aqua ligand and a nitrate ion. While two symmetry-related Co1 ions are connected by one fumarate ligand to generate a dinuclear unit and obix ligand links adjacent dinuclear units through the nitrogen atoms to form a 1D double chains in 1, each mbix ligand links two Co1 ions to form 1D double chains, and the adjacent chains are further linked together by fumarate ligands to form a 2D network in 2. The effect of bis(imidazole) ligands, which are o- and m-isomers, on the dimensionality of the formed coordination polymer was investigated. The reason for this great effect of bis(imidazole) ligands is that adjustments in the framework occur result of the bending of the semi-rigid imidazole ligands. Thermal analysis shows that 1 and 2 possess similar thermal behaviors. The optical band gap energy values of 1 and 2 observed 3.24 eV and 3.21 eV, respectively. This small difference in the band gap energy may be due to the difference in structural arrangement.