bluuebunny/crossref_metadata_2025 huggingface dataset:
Microsatellite Instability as a Biomarker for PD-1 Blockade
Authors: Dudley Jonathan C. , Lin Ming-Tseh , Le Dung T. , Eshleman James R.
Published: February 2016

Initial results by Le and colleagues, which were published in the June 25, 2015 issue of the New England Journal of Medicine, report significant responses of cancers with microsatellite instability (MSI) to anti–PD-1 inhibitors in patients who failed conventional therapy. This finding fits into a broader body of research associating somatic hypermutation and neoepitope formation with response to immunotherapy, with the added benefit of relying on a simple, widely used diagnostic test. This review surveys the pathogenesis and prognostic value of MSI, diagnostic guidelines for detecting it, and the frequency of MSI across tumors, with the goal of providing a reference for its use as a biomarker for PD-1 blockade. MSI usually arises from either germline mutations in components of the mismatch repair (MMR) machinery (MSH2, MSH6, MLH1, PMS2) in patients with Lynch syndrome or somatic hypermethylation of the MLH1 promoter. The result is a cancer with a 10- to 100-fold increase in mutations, associated in the colon with poor differentiation, an intense lymphocytic infiltrate, and a superior prognosis. Diagnostic approaches have evolved since the early 1990s, from relying exclusively on clinical criteria to incorporating pathologic features, PCR-based MSI testing, and immunohistochemistry for loss of MMR component expression. Tumor types can be grouped into categories based on the frequency of MSI, from colorectal (20%) and endometrial (22%–33%) to cervical (8%) and esophageal (7%) to skin and breast cancers (0%–2%). If initial results are validated, MSI testing could have an expanded role as a tool in the armamentarium of precision medicine. Clin Cancer Res; 22(4); 813–20. ©2016 AACR.
A Large-Scale Investigation of Hypoxia-Preconditioned Allogeneic Mesenchymal Stem Cells for Myocardial Repair in Nonhuman Primates
Authors: Hu Xinyang , Xu Yinchuan , Zhong Zhiwei , Wu Yan , Zhao Jing , Wang Yingchao , Cheng Haifeng , Kong Minjian , Zhang Fengjiang , Chen Qi , Sun Jianzhong , Li Qian , Jin Jing , Li Qingju , Chen Lihong , Wang Chen , Zhan Hongwei , Fan Youqi , Yang Qian , Yu Lei , Wu Rongrong , Liang Jie , Zhu Jinyun , Wang Ya , Jin Yiping , Lin Yifan , Yang Fan , Jia Liangliang , Zhu Wei , Chen Jinghai , Yu Hong , Zhang Jianyi , Wang Jian’an
Published: February 2016

Rationale:

The effectiveness of transplanted bone marrow mesenchymal stem cells (MSCs) for cardiac repair has been limited; thus, strategies for optimizing stem-cell–based myocardial therapy are needed.

Objective:

The present study was designed to test our central hypothesis that hypoxia-preconditioned MSCs (HP-MSCs) are more effective than MSCs cultured under ambient oxygen levels for the treatment of myocardial injury in a large-scale (N=49), long-term (9 months), nonhuman primate (Cynomolgous monkeys) investigation.

Methods and Results:

MSCs were engineered to express green fluorescent protein, cultured under ambient oxygen or 0.5% oxygen (HP-MSCs) for 24 hours and then tested in the infarcted hearts of Cynomolgus monkeys (1×10
7
cells per heart). Hypoxia preconditioning increased the expression of several prosurvival/proangiogenic factors in cultured MSCs, and measurements of infarct size and left-ventricular function at day 90 after myocardial infarction were significantly more improved in monkeys treated with HP-MSCs than in monkeys treated with the control vehicle; functional improvements in normal cultured bone marrow mesenchymal stem cells–treated monkeys were not significant. HP-MSCs transplantation was also associated with increases in cardiomyocyte proliferation, vascular density, myocardial glucose uptake, and engraftment of the transplanted cells and with declines in endogenous cell apoptosis, but did not increase the occurrence of arrhythmogenic complications.

Conclusions:

Hypoxia preconditioning improved the effectiveness of MSCs transplantation for the treatment of myocardial infarction in nonhuman primates without increasing the occurrence of arrhythmogenic complications, which suggests that future clinical trials of HP-MSCs transplantation are warranted.
Long-Term Outcome of Administration of c-kit
POS
Cardiac Progenitor Cells After Acute Myocardial Infarction
Authors: Tang Xian-Liang , Li Qianhong , Rokosh Gregg , Sanganalmath Santosh K. , Chen Ning , Ou Qinghui , Stowers Heather , Hunt Greg , Bolli Roberto
Published: February 2016

Rationale:

Cardiac progenitor cells (CPCs) improve left ventricular remodeling and function after acute or chronic myocardial infarction. However, the long-term (>5 weeks) effects, potential tumorigenicity, and fate of transplanted CPCs are unknown.

Objective:

To assess the outcome of CPC therapy at 1 year.

Methods and Results:

Female rats underwent a 90-minute coronary occlusion; 4 hours after reperfusion, they received intracoronarily vehicle or 1 million male, syngeneic CPCs. One year later, CPC-treated rats exhibited smaller scars and more viable myocardium in the risk region, along with improved left ventricular remodeling and regional and global left ventricular function. No tumors were observed. Some transplanted (Y-chromosome
POS
) CPCs (or their progeny) persisted and continued to proliferate, but they failed to acquire a mature cardiomyocyte phenotype and were too few (4–8% of nuclei) to account for the benefits of CPC therapy. Surprisingly, CPC transplantation triggered a prolonged proliferative response of endogenous cells, resulting in increased formation of endothelial cells and Y-chromosome
NEG
CPCs for 12 months and increased formation, for at least 7 months, of small cells that expressed cardiomyocytic proteins (α-sarcomeric actin) but did not have a mature cardiomyocyte phenotype.

Conclusions:

The beneficial effects of CPCs on left ventricular remodeling and dysfunction are sustained for at least 1 year and thus are likely to be permanent. Because transplanted CPCs do not differentiate into mature myocytes, their major mechanism of action must involve paracrine actions. These paracrine mechanisms could be very prolonged because some CPCs engraft, proliferate, and persist at 1 year. This is the first report that transplantation of any cell type in the heart induces a proliferative response that lasts at least 1 year. The results strongly support the safety and clinical utility of CPC therapy.
NSun2 Deficiency Protects Endothelium From Inflammation via mRNA Methylation of ICAM-1
Authors: Luo Yuhong , Feng Juan , Xu Qingbo , Wang Wengong , Wang Xian
Published: February 2016

Rationale
:

Vascular endothelial inflammation, including the expression of intercellular adhesion molecule 1 (ICAM-1), is a key event in vascular diseases. However, the mechanisms underlying the regulation of ICAM-1 are largely unknown.

Objective
:

To investigate the mechanisms on the regulation of ICAM-1 by NOP2/Sun domain family, member 2 (NSun2)-mediated mRNA methylation and the impact of NSun2–ICAM-1 regulatory process in vascular inflammation and allograft arteriosclerosis.

Methods and Results
:

By using in vitro, in cells, and in vivo methylation assays, we showed that the tRNA methyltransferase NSun2 methylated the ICAM-1 mRNA. Methylation by NSun2 promoted the translation of ICAM-1, thereby increasing the adhesion of leukocytes to endothelial cells. Tumor necrosis factor-α or homocysteine activated the methyltransferase activity of NSun2 by repressing the phosphorylation of NSun2 by Aurora-B. The levels of ICAM-1 induction and of leukocyte adhesion to vascular endothelium observed with homocysteine treatment in wild-type rats were markedly decreased in NSun2
−/−
rats. In a rat model of aortic allograft, the lack of donor NSun2 impaired the formation of allograft arteriosclerosis.

Conclusions
:

NSun2 upregulates the expression of ICAM-1 by methylating ICAM-1 mRNA. This regulatory process impacts on vascular inflammation and allograft arteriosclerosis.
The Suharto Case
Authors: Suh Jiwon
Published: February 2016

How could Suharto avoid prosecution for human rights abuses? For a preliminary answer, this paper provides an account of a specific and observable failure: The failure of the Suharto study team, a Komnas-HAM (National Commission of Human Rights) initiative to put the atrocities of the Suharto era on the human rights court track. It begins with prosecutorial approaches toward past abuses and a lack of coordination over transitional justice strategies in Indonesia as the background to Suharto’s non-prosecution. Then, it proceeds to trace the Suharto study team’s life in 2003 until its defeat. The fate of the Suharto team highlights the dilemma of timing between public attention and political capabilities in transitional justice. Five years after Suharto stepped down, legacies from the past prevented progress in the case, while the impact was far from explosive when new commissioners of the Komnas-HAM finally announced the findings of gross violations in 2012.
Obstacles and catalysts of cooperation in humans, bonobos, and chimpanzees: behavioural reaction norms can help explain variation in sex roles, inequality, war and peace
Authors: Jaeggi Adrian V. , Boose Klaree J. , White Frances J. , Gurven Michael
Published: February 2016

Our closest living relatives, bonobos and chimpanzees, along with small-scale human societies figure prominently in debates about human nature. Here we emphasize and explain behavioural variation within and among these three species. In the logic of behavioural ecology, individuals have been selected to adjust their behaviour along evolved reaction norms that maximize fitness given current socio-ecological conditions. We discuss variation in three behavioural contexts: relationships between the sexes, hierarchy and inequality, and intergroup interactions. In each context, behavioural variation can be related to two broad socio-ecological conditions: (i) the defensibility of contested resources, and (ii) differences in bargaining power. When defensibility of resources and differences in bargaining power are great, interactions are rife with conflict; when they are minimal, interactions are more harmonious. These socio-ecological conditions therefore constitute key catalysts and obstacles of cooperation. We conclude that human nature should be seen as consisting of evolved reaction norms.
A checklist of marine crustaceans known from Easter Island
Authors: De los Ríos Escalante Patricio , Ibáñez Arancibia Eliana
Published: February 2016

Easter Island constitutes the most isolated terrestrial ecosystem in the Pacific Ocean. The fauna of that site is interesting from a biogeographical point of view because species from Pacific Asia and South America can be found there, as well as endemic species. The aim of the present study was to compile a literature review of published records of marine Crustacea from Easter Island with the emphasis on the heterogeneity in habitats reported for each species. The results confirm the presence of species otherwise known from Pacific Asia, South America, as well as the expected endemic species. In spite of the little information that is generally provided in the habitat records for most species, it may still be possible to find a marked heterogeneity of ecosystems, together generating a complex system that warrants more detailed studies.
The Cephenniini of China. VIII. New species and new records of Cephennodes Reitter of Hunan, Jiangxi, Zhejian and Fujian (Coleoptera: Staphylinidae: Scydmaeninae)
Authors: JAŁOSZYŃSKI PAWEŁ
Published: February 2016

Seven new species of Cephennodes Reitter of mainland China are described, all in the nominotypical subgenus: C. brachyspinosus sp. n. (Hunan), C. impressibos sp. n. (Jiangxi), C. hystrix sp. n. (Zhejiang), C. setifer sp. n. (Zhejiang), C. yinziweii sp. n. (Zhejiang), C. datianpingensis sp. n. (Zhejiang), and C. bicribratus sp. n. (Zhejiang). Two species are placed in the Cephennodes bos species group (C. brachyspinosus and C. impressibos), three in the Cephennodes longipes group (C. hystrix, C. setifer and C. yinziweii), and two in a newly established Cephennodes elytratus group (C. datianpingensis and C. bicribratus). Additionally, three previously described species are recorded from new localities: C. capricornis Jałoszyński from Hunan and Zhejiang, C. clypeicornis Jałoszyński from Zhejiang and C. paramerus Jałoszyński from Fujian and Zhejiang. Cephennodes is for the first time reported to occur in Hunan Province.
A revision of the genus Leberis Smirnov, 1989 (Cladocera: Chydoridae) in the Old World and Australia
Authors: NERETINA ANNA N. , SINEV ARTEM Y.
Published: February 2016

A comparison between populations of the diaphanus-group of Leberis Smirnov, 1989 from Australia and India confirmed that Australian L. diaphanus (King, 1853) and Indian L. punctatus (Daday, 1898) are separate species. Morphology of parthenogenetic females of L. punctatus is redescribed for the first time. Some fine details of morphology are re-examined in other species of Leberis, taxonomically significant features and their variability are studied. In the Old World L. punctatus could be confused with L. diaphanus, but the former differs from the latter mainly in the details of thoracic limbs I and IV. Both species have relatively broad distribution ranges: L. punctatus inhabits South Asia, Africa and penetrates Southeast Asia, L. diaphanus is a widespread taxon in the water bodies of Australia, Southeast Asia and South China. Diversity of the genus in the Old World is underestimated yet, and further investigations are desirable.
Large-Scale Atmospheric Warming in Winter and the Arctic Sea Ice Retreat
Authors: Dobricic Srdjan , Vignati Elisabetta , Russo Simone
Published: February 2016

The ongoing shrinkage of the Arctic sea ice cover is likely linked to the global temperature rise, the pronounced warming in the Arctic, and possibly weather anomalies in the midlatitudes. By evaluating independent components of global atmospheric energy anomalies in winters from 1980 to 2015, the study finds the link between the sea ice melting in the Arctic and the combination of only three well-known atmospheric oscillation patterns approximating observed spatial variations of near-surface temperature trends in winter. The three patterns are the North Atlantic Oscillation (NAO), Scandinavian blocking (SB), and El Niño–Southern Oscillation (ENSO). The first two are directly related to the ongoing sea ice cover shrinkage in the Barents Sea and the hemispheric increase of near-surface temperature. By independent dynamical processes they connect the sea ice melting and related atmospheric perturbations in the Arctic either with the negative phase of the NAO or the negative trend of atmospheric temperatures over the tropical Pacific. The study further shows that the ongoing sea ice melting may often imply the formation of large-scale circulation patterns bringing the recent trend of colder winters in densely populated areas like Europe and North America.
A Longitudinal Study of the Temporal Relation Between Problem Gambling and Mental and Substance Use Disorders Among Young Adults
Authors: Afifi Tracie O. , Nicholson Ryan , Martins Silvia S. , Sareen Jitender
Published: February 2016

Objective:

Relatively little is known about the temporal relation between at-risk gambling or problem gambling (PG) and mental and substance use disorders (SUDs) in young adulthood. Our study aimed to examine whether past-year, at-risk, or PG is associated with incident mental disorders and SUDs (that is, depression, generalized anxiety disorder, obsessive–compulsive disorder [OCD], or alcohol dependence) and illegal drug use, and whether past-year mental disorders and SUDs and illegal drug use is associated with incident at-risk or PG.

Method:

Data for this longitudinal study were drawn from the Manitoba Longitudinal Study of Young Adults (MLSYA). Respondents aged 18 to 20 years in 2007 were followed prospectively for 5 years.

Results:

In cross-sectional analyses, at-risk or PG was associated with increased odds of depression, OCD, alcohol dependence, and illegal drug use. In longitudinal analysis at-risk or PG at cycle 1 was associated with incident major depressive disorder, alcohol dependence, and illegal drug use in the follow-up period. Only illegal drug use at cycle 1 was associated with incident at-risk or PG during follow-up.

Conclusions:

At-risk or PG was associated with more new onset mental disorders and SUDs (depression, alcohol dependence, and illegal drug use), compared with the reverse (illegal drug use was the only association with new onset at-risk or PG). Preventing at-risk or PG from developing early in adulthood may correspond with decreases in new onset mental disorders and SUDs later in adulthood.
No Mental Health without Oral Health
Authors: Kisely Steve
Published: February 2016

The poor physical health faced by people with mental illness has been the subject of growing attention, but there has been less focus on the issue of oral health even though it is an important part of physical health. This article discusses the two-way association between oral and mental health. In one direction, the prospect of dental treatment can lead to anxiety and phobia. In the other, many psychiatric disorders, such as severe mental illness, affective disorders, and eating disorders, are associated with dental disease: These include erosion, caries, and periodontitis. Left untreated, dental diseases can lead to teeth loss such that people with severe mental illness have 2.7 times the likelihood of losing all their teeth, compared with the general population. Possible interventions include oral health assessments using standard checklists that can be completed by nondental personnel, help with oral hygiene, management of iatrogenic dry mouth, and early dental referral.
Labour Market Conditions–Female Labour Supply Nexus: The Role of Globalization in Pakistan
Authors: Mujahid Nooreen , Shabbir Muhammad Shahbaz , Shahbaz Muhammad
Published: February 2016

This study examines the impact of female wages, unemployment, foreign remittances and globalization on female labour supply over the period from 1980 to 2010. We have applied the autoregressive distributive lag (ARDL) bounds testing to test whether cointegration exists between variables. Our results show that variables are integrated for a long-run relationship. Moreover, female wages attract female labour supply. Foreign remittances and globalization raise female labour supply, whereas unemployment lowers it. The relation between female wages and female labour supply is U-shaped. The causality analysis reveals that female wages, foreign remittances, globalization and unemployment Granger affect female labour supply.
Coping with Climatic Shocks: Empirical Evidence from Rural Coastal Odisha, India
Authors: Patnaik Unmesh , Das Prasun Kumar , Bahinipati Chandra Sekhar
Published: February 2016

Households in India face numerous climatic shocks, including cyclones and floods, and these extreme events have a negative impact on their welfare. Although these impacts are likely to increase in the foreseeable future due to climate change, households are also taking up various coping measures to deal with the impacts from past shocks. Hence, assessing the impact of shocks and identifying the determinants of various coping options have relevant policy implications in the context of designing a disaster mitigation policy. This study examines the consumption behaviour and the determinants of traditional coping mechanisms adopted by the vulnerable households using household-level data collected from cyclone and flood prone districts of the state of Odisha in eastern India. The findings suggest that: (i) partial consumption smoothing is exhibited with respect to household-specific characteristics, (ii) increasing impacts on assets and health expenditure due to floods inhibit consumption patterns of households and (iii) the adopted traditional coping mechanisms are specific to location and household characteristics.
Antecedents of Organizational Identification of Postgraduate Students and Its Impact on Institutions
Authors: Chawla Deepak , Srivastava Jaya
Published: February 2016

Through this article, we have tried to identify the factors that lead to organizational identification of postgraduate students with the institutes in which they are studying. The idea was to find out what contributes to strong identification with the institute and how this identification with the organization leads to mutual benefit. For the current study, a sample of 275 postgraduate students studying in various management colleges in the National Capital Region (NCR) was administered a questionnaire. The analysis of the data indicates that identification with the institute is heavily influenced by clarity regarding recruiters expectations; this was followed by information sharing, participation in decision making and lastly by performance feedback. The findings of this study are useful for academic administrators in policy making and institution building. They can get a better insight into the minds of students and assess what factors are perceived as most important for them, while identifying with the institute in which they are studying.
Another Look in Conditioning Alphas on Economic Information: Indian Evidence
Authors: Roy Subrata
Published: February 2016

No doubt, Jensen measure is path breaking in the field of investment performance, particularly in stock selection. A large number of Indian researchers have evaluated stock-selection performance of mutual fund managers by using the traditional measure of Jensen and have reported a mixed result. If we think differently, then we can see that the conditional measure provides better performance when compared with the traditional Jensen measure. In India, the performance evaluation of mutual fund based on conditional measure is scanty, while other developed economies have extensively examined the conditional performance and depicted superior results. Therefore, this study makes an attempt to evaluate stock-selection performance of open-ended equity mutual fund managers based on the conditional model and makes a comparison between the traditional model (unconditional) and the conditional model. The finding of the present study is remarkable. After the inclusion of the available public information in the conditional model, the significant stock-selection performance is increased and the alpha values in all cases are improved when compared with the unconditional model. Finally, the statistical test implies that there is significant difference between the two measures in respect of stock-selection performance.
Multifunctional Roads
Authors: Demenge Jonathan , Alba Rossella , Welle Katharina , Manjur Kebede , Addisu Alemu , Mehta Lyla , Woldearegay Kifle
Published: February 2016

Rural roads are built to improve people’s mobility and to enhance access to markets, administrative centres, schools and health posts, and are credited with important socio-economic changes. A less studied aspect is the impact of roads on hydrological resources, as roads interact with existing surface and groundwater flows, redistributing water-related hazards and resources across space with significant consequences on people and their livelihoods. In Ethiopia, the government has embarked on a massive road construction programme over the last decade, mainly to serve the needs of an essentially rural population and agrarian economy. In parallel, the government has also been investing significantly in water harvesting and conservation measures and irrigation to serve the needs of a population whose livelihoods depend heavily on rain-fed agriculture. Based on fieldwork conducted in 2014 in the semi-arid region of Tigray, Ethiopia, this article explores the opportunities and potential for multifunctional infrastructures. We argue that the two distinctive objectives of improving road connectivity and water availability for irrigation are interlinked and can be served by the same infrastructure, which we call multifunctional roads.
Breaking the cycle of discrimination? Traveller/Roma housing exclusion and the European Convention on Human Rights
Authors: O’Donovan Darren
Published: February 2016

Recent legal and policy developments concerning Europe’s Traveller/Roma have brought into sharp focus the structural inequalities facing traditionally nomadic minorities. Despite such interventions however, European human rights norms have struggled to address an equality challenge that exists at the interface of indirect discrimination, socio-economic rights and multiculturalism. To illustrate the policy and legislative dynamics underpinning Traveller/Roma exclusion, this article critically analyses the difficulties of accessing culturally appropriate housing for the Irish Travelling Community. It highlights how Irish litigation on behalf of Travellers has tested the boundaries of Article 8 of the European Convention on Human Rights, particularly the extent to which a minimum core of accommodation provision may be secured. The article argues that the recent European Court on Human Rights case of Winterstein v. France provides fresh impetus for the protection of Traveller/Roma cultural identity in the housing sphere.
Executive orders for human rights
Authors: Gates Trevor G , Saunders Margery C
Published: February 2016

The present article analyzes Executive Order 13672, which extends workplace protections to lesbian, gay, bisexual, and transgender (LGBT) workers who are employed or seeking jobs with federal contractors in the United States. The US Constitution gives presidents power to act in the public interest by issuing directives to federal agencies, and these policies have the potential for addressing discrimination, social justice, and human rights issues. Implications for how executive orders may be further used to advance human rights, particularly nondiscrimination efforts, and to advocate for LGBT workers are explored.
Delineation of post-KPg carbonate slope deposits as a sedimentary record of the Paleogene linkage of De Soto Canyon and Suwannee Strait, northern Gulf of Mexico
Authors: Umbarger Keelan F. , Snedden John W.
Published: February 2016

Seismicity generated from the Chicxulub impact has been postulated as the cause for the dramatic alteration of basin margin morphology and catastrophic movement of sediments in the Gulf of Mexico (GOM). Immediately following the impact, the formation of the Cretaceous-Paleogene boundary deposit (KPBD) was widespread and caused considerable erosion as portions of the Florida Escarpment collapsed, inducing sediment failure on the northern Florida Platform and formation of the ancestral De Soto Canyon. Overlying the more prominent KPBD existed a distinct, younger, post-Cretaceous/Paleogene carbonate slope deposit (CSD) confined within the De Soto Canyon bathymetric feature. Presence of this discrete unit provided insight into the post-impact history of De Soto Canyon and its long-duration connection to the Suwannee Strait, which linked the GOM with the Atlantic Ocean for almost 40 ma. We have postulated that the bathymetric low of the De Soto Canyon acted as a conduit for west to east sediment movement from nearby carbonate-dominated shorelines into the canyon in episodic sediment transport events from the Danian to the earliest Miocene. Closure of the Suwannee Strait, due to sediment infilling, terminated deposition of the De Soto Canyon CSD. This was followed by major siliciclastic influx as the paleo-Tennessee drainage system began to enter the Mississippi Canyon area.
Semisupervised multiattribute seismic facies analysis
Authors: Qi Jie , Lin Tengfei , Zhao Tao , Li Fangyu , Marfurt Kurt
Published: February 2016

One of the key components of traditional seismic interpretation is to associate or “label” a specific seismic amplitude package of reflectors with an appropriate seismic or geologic facies. The object of seismic clustering algorithms is to use a computer to accelerate this process, allowing one to generate interpreted facies for large 3D volumes. Determining which attributes best quantify a specific amplitude or morphology component seen by the human interpreter is critical to successful clustering. Unfortunately, many patterns, such as coherence images of salt domes, result in a salt-and-pepper classification. Application of 3D Kuwahara median filters smooths the interior attribute response and sharpens the contrast between neighboring facies, thereby preconditioning the attribute volumes for subsequent clustering. In our workflow, the interpreter manually painted [Formula: see text] target facies using traditional interpretation techniques, resulting in attribute training data for each facies. Candidate attributes were evaluated by crosscorrelating their histogram for each facies with low correlation implying good facies discrimination, and Kuwahara filtering significantly increased this discrimination. Multiattribute voxels for the [Formula: see text] interpreter-painted facies were projected against a generative topographical mapping manifold, resulting in [Formula: see text] probability density functions (PDFs). The Bhattacharyya distance between the PDF of each unlabeled voxel to each of [Formula: see text] facies PDFs resulted in a probability volume of each user-defined facies. We have determined the effectiveness of this workflow to a large 3D seismic volume acquired offshore Louisiana, USA.
Display and enhancement of volumetric fault images
Authors: Machado Gabriel , Alali Abdulmohsen , Hutchinson Bryce , Olorunsola Oluwatobi , Marfurt Kurt J.
Published: February 2016

Fault picking is a critical, but human-labor-intensive component of seismic interpretation. In a bid to improve fault imaging in seismic data, we have applied a directional Laplacian of a Gaussian operator to sharpen fault features within a coherence volume. We computed an [Formula: see text] matrix of the second moment tensor distance-weighted coherence values that fell within a 3D analysis window about each voxel. The eigenvectors of this matrix defined the orientation of planar discontinuities, whereas the corresponding eigenvalues determined whether these discontinuities were significant. The eigenvectors, which quantified the fault dip magnitude and dip azimuth, defined a natural coordinate system for smoothing of the planar discontinuity. We rotated the data to the new coordinate system and applied the sharpening operator. By comparing the vector dip of the discontinuity to the vector dip of the reflectors, we could apply a filter to either suppress or enhance discontinuities associated with unconformities or low-signal-to-noise-ratio shale-on-shale reflectors. We have revealed the value and robustness of the technique by application to two 3D data volumes from offshore New Zealand, which exhibited polygonal faulting, shale dewatering, and mass transport complexes.
Compelling evidence from eastern Mexico for a Late Paleocene/Early Eocene isolation, drawdown, and refill of the Gulf of Mexico
Authors: Cossey Stephen P. J. , Van Nieuwenhuise Don , Davis Joseph , Rosenfeld Joshua H. , Pindell James
Published: February 2016

Outcrops of the Paleocene/Eocene Chicontepec Formation in eastern Mexico have provided a unique opportunity to study exposed time-equivalent sections of the deepwater Gulf of Mexico (GOM) Wilcox Formation. A 2012 study established a stratigraphic framework in the Tampico-Misantla Basin (TMB) and identified sequence boundaries that could not be correlated globally. Fieldwork in 2008 had also established a network of paleocanyons in the basin associated with a particular “54 Ma” sequence boundary. At that time, a Paleocene turbidite basin fed from the northwest was incised by a collection of northeast-facing erosional canyons that coalesced laterally into the main southeast-trending Chicontepec paleocanyon; this canyon network was filled in the Early Eocene. Using the 2012 study chronostratigraphic scheme, recent micropaleontological studies were performed on a unique outcrop containing a bitumen bed within one of these paleocanyons. The results suggest that the basin’s water level fell rapidly by at least 200 m, starting after 55.8 Ma and leading to subaerial exposure of the bathyal beds for a maximum of 850,000 years prior to canyon refill. Evidence of rooting (limonite tubes) occurs in the bathyal turbidites below the bitumen bed. At this time, the paleocanyons in the TMB were eroded by fluvial systems feeding directly into the central Gulf basin, probably a land-locked sea. The interpreted large and rapid fall and rise of the water level between 55.8 and 54.95 Ma supports the “GOM drawdown hypothesis,” i.e., that the GOM may have been isolated from the world’s oceans due to the closure of the Florida straits as the Cuban arc collided with the Bahamas and northeast Yucatán. The timing of the interpreted drawdown coincides with the Paleocene-Eocene thermal maximum (PETM), hinting that the PETM may have been caused or assisted by the release of methane from hydrates in the GOM margins and abyssal plain.
Vector and Scalar IMs in Structural Response Estimation, Part I: Hazard Analysis
Authors: Kohrangi Mohsen , Bazzurro Paolo , Vamvatsikos Dimitrios
Published: February 2016

A realistic assessment of building economic losses and collapse induced by earthquakes requires the monitoring of several response measures, both story-specific and global. The prediction of such response measures benefits from using multiple ground motion intensity measures (IMs) that are, in general, correlated. To allow the inclusion of multiple IMs in the risk assessment process, it is necessary to have a practical tool that computes the vector-valued hazard of all such IMs at the building site. In this paper, vector-valued probabilistic seismic hazard analysis (VPSHA) is implemented here as a post-processor to scalar PSHA results. A group of candidate scalar and vector IMs based on spectral acceleration values, ratios of spectral acceleration values, and spectral accelerations averaged over a period range are defined and their hazard evaluated. These IMs are used as structural response predictors of three-dimensional (3-D) models of reinforced concrete buildings described in a companion paper ( Kohrangi et al. 2016 ).
Making Emends: Adrienne Rich, Audre Lorde, Anne Bradstreet
Authors: Rust Marion
Published: February 2016

This essay examines two versions of an essay by Adrienne Rich on Anne Bradstreet to argue that Rich's intervening relationship with Audre Lorde facilitated her development of a rhetorical technique I call additive emendation. This method allowed her to supplement the original essay so as to both comment on its errors and let them remain evident to the reader. Lorde's emphasis on knowledge as an ongoing phenomenon rather than a finite commodity, and her understanding of prose as a means to inscribe that process, informed this technique and became evident to Rich in a series of contentious print exchanges between them. As such, the three pairings in this essay—Rich and Bradstreet, Lorde and Rich, and Rich's later and earlier authorial personae—reflect the feminist phenomenon of the open letter, whereby anger, rather than critical dispassion, founds argumentative cogency.
The Novel of Human Rights
Authors: Dawes James
Published: February 2016

In this essay, I identify the centers of aesthetic gravity that pull texts together into what I have come to think of as a subgenre of the contemporary US novel: namely, the novel of human rights. What connective structures and recurring concerns can be discerned at this early stage in the development of the subgenre? How do its ethical pressures generate formal patterns and, in turn, how do its formal patterns generate ethical pressures? And finally, since both the textual and political forms are rapidly evolving, what can this rising subgenre teach us about the near futures of literature and literary studies in the United States?
Forms of Duration: Preparedness, the Mars Trilogy, and the Management of Climate Change
Authors: Thomas Lindsay
Published: February 2016

This essay examines two kinds of speculative fiction focused on the management of climate change: preparedness documents on climate change as a threat to national security, and Kim Stanley Robinson's Mars trilogy (1993–96), a science fiction trilogy about the terraformation and colonization of Mars. Focusing on narrative scenarios and exercises that train officials to respond to natural disasters, this essay positions these preparedness documents as part of a system of affective management. They teach participants to cultivate a feeling of neutral detachment—to stay calm and cool so that they can react automatically and repeatedly when disaster strikes. This emphasis on detachment and repetition reveals the political stakes of preparedness as a national security paradigm: to maintain the status quo by extending the always-catastrophic present into the future. The essay's second half turns to the Mars trilogy to argue that by emphasizing duration, or the heterogeneous lasting of time, the trilogy invites its readers to experience climate change as the intersection of various scales and compositions of time, both human and nonhuman. Demonstrating that the management of climate change is inseparable from an experience of it, the Mars books challenge preparedness by emphasizing ongoing change rather than the containment of a never-ending series of disasters.
Characteristic Tonality in theBallettiof Gastoldi, Morley, and Hassler
Authors: Long Megan Kaes
Published: February 2016

In 1595 Thomas Morley published The First Booke of Balletts, a collection of “Italian madrigals Englished.” Rather than writing English words for unaltered Italian works as his predecessors had done, Morley created original compositions loosely modeled on Italian works. Analysis of Morley's balletts reveals four primary “Englishing” techniques. First, Morley establishes and confirms tonic more thoroughly than the Italians do. Second, the dominant chord plays a larger role in Morley's balletts, often yielding predictive statement-response phrase structures. Third, Morley uses pre-dominant chords at cadences (yielding tonic–pre-dominant–dominant–tonic syntax) more regularly than his models do. Finally, in the rare instances that he chooses models without periodic phrase structure, Morley introduces periodicity. Morley's recompositions contribute to the tonal sound that, historically, scholars have identified with the English madrigal. To situate this repertoire in relation to repertoires we more commonly identify as tonal, this article introduces the notion of characteristic tonality, an inclusive concept that provides a vocabulary for analyzing and distinguishing among repertoires with tonal features. To demonstrate the utility of characteristic tonality, the article concludes by comparing the tonal language of German-texted balletts by Hans Leo Hassler with those of Morley and his Italian models. These three repertoires manifest tonal characteristics in richly multifaceted ways; points of contact between them provide insight into precise agents of musical change around the turn of the seventeenth century.
All Hail the Q.U.E.E.N.: Janelle Monáe and a Tale of the Tux
Authors: Miller Monica L.
Published: February 2016

This essay examines musician and style icon Janelle Monáe’s signature suit of clothes—her tuxedo—and argues that the tuxedo and its accompanying styling create productive tensions between restraint and abandon, typicality and queerness, captivity and freedom. For Monáe, these tensions fuel her creative work on the musical stage and also in the realm of fashion and style; they become a way of naturalizing the oddness and radicality of her liberating and liberatory rhetoric concerning racial stereotypes, gender norms, class assumptions, and perceptions of sexuality. Examining the mythology surrounding Monáe’s public presentation, as well as the styling of the videos for “Tightrope” and “Q.U.E.E.N.,” I argue that Monáe insists on a playfully clad and performative “embodied knowledge” as a basis for her android revolution.
Extraction of Betanin Using Aqueous Two-Phase Systems
Authors: Ebrahimi Tahereh , Shahriari Shahla
Published: February 2016

The extraction efficiency of betanin as a natural pigment with antioxidant features is significant. The main reason for studying the different aqueous two-phase systems (ATPSs) for betanin extraction is that the selection of an optimum process of separation is possible. In order to develop an efficient method for the extraction of betanin, ATPS composed of polymer and sodium sulfate was investigated. Sodium sulfate is a strong salting-out agent, which has an important effect on the processes of the extraction of biomolecules. The effect of parameters such as temperature, salt and polymer concentrations, and the molecular weight of the polymer was evaluated for the partitioning of betanin. The experimental results showed that the polymer concentrations in ATPS can significantly affect the partitioning of betanin between the top and bottom phases. The recovery percentage of betanin indicated that this system had the ability to improve the betanin recovery in the top phase.
Amor à primeira vista: o desafio da licença maternidade dupla
Authors: Menegon Leticia Fantinato , Casado Tania
Published: February 2016

O caso conta a história de Gabriela e Carla, duas mulheres ligadas por uma união homoafetiva que estão às vésperas do nascimento de suas filhas gêmeas. Carla é a doadora do óvulo fertilizado por um doador anônimo, que foi implantado em Gabriela. As duas são profissionais de uma empresa no Brasil, onde as leis trabalhistas e as práticas de gestão de pessoas não contemplam casos como o delas. Sabedoras do ineditismo de sua história, elas pleiteiam uma dupla licença-maternidade à área de Recursos Humanos da empresa. O caso é destinado a cursos de Administração em nível de graduação, nas disciplinas e, que os temas cultura organizacional, valores, justiça organizacional, globalização e gênero sejam ministrados. DOI: 10.12660/gvcasosv5n2c15http://dx.doi.org/10.12660/gvcasosv5n2c15
A internacionalização das Vinícolas Carrau
Authors: Bidarte Marcos Vinicius Dalagostini , Londero Henrique Kneipp , Camacho Jandira Júlia Vieira , De Oliveira Marta Olivia Rovedder
Published: February 2016

O caso descreve a internacionalização das Vinícolas Carrau, uma tradicional empresa familiar uruguaia. Mostra o esforço despendido pela empresa para estudar o mercado brasileiro de vinhos como forma de alocar os seus produtos, e discute as potencialidades e limitações do negócio em seu processo de internacionalização. Destina-se a cursos de graduação, pós-graduação stricto sensu e mestrado profissional nas disciplinas de Marketing, Marketing Internacional, Negócios Internacionais e Comércio Exterior.DOI: 10.12660/gvcasosv5n2c8http://dx.doi.org/10.12660/gvcasosv5n2c8
Um estranho no ninho ou um ninho para um estranho? Um caso de socialização no processo de expatriação
Authors: Couto Felipe Fróes , Saraiva Luiz Alex Silva
Published: February 2016

O caso trata da história de Trinity, estrangeira dinamarquesa designada a vir ao Brasil com a missão de estruturar uma área de suporte aos negócios, que encontra uma cultura totalmente receptiva, em alguns aspectos, e nem tanto, em outros. Entre os aspectos mais relevantes do caso, se destacam o choque cultural na recepção da estrangeira; a ausência de clareza acerca da significação atribuída à presença do estrangeiro no ambiente de trabalho, e as resistências brasileiras às mudanças trazidas pelo estrangeiro. O caso pode ser lido em poucos minutos e pode ser utilizado para promover discussões e debates em disciplinas de graduação e pós-graduação relacionadas a estudos organizacionais, estudos sociais, gestão de pessoas, entre outras.DOI: 10.12660/gvcasosv5n2c9http://dx.doi.org/10.12660/gvcasosv5n2c9
The retirement dilemma: what to do now? (Notas de Ensino)
Authors: Linzmeyer Simone Maria Virmond Vieira , Nakata Lina Eiko , Casado Tania
Published: February 2016

DOI: 10.12660/gvcasosv5n2n12http://dx.doi.org/10.12660/gvcasosv5n2n12
Um estranho no ninho ou um ninho para um estranho? Um caso de socialização no processo de expatriação (Notas de Ensino)
Authors: Couto Felipe Fróes , Saraiva Luiz Alex Silva
Published: February 2016

DOI: 10.12660/gvcasosv5n2n9http://dx.doi.org/10.12660/gvcasosv5n2n9
Πότε ο Φίλιππος Β' έλαβε τον τίτλο του βασιλέως
Authors: Κανατσούλης Δ.
Published: February 2016

No abstract
Ένα φιρμάνι για την ανέργεση της πρώτης εκκλησίας των Γενιτσών
Authors: Δημητριάδης Βασίλης
Published: February 2016

No abstract
Συμπληρωματικά δια τον Ιωάννην Κωτούνιον
Authors: Βασδραβέλλης Ι. Κ.
Published: February 2016

No abstract
Παναγιώτου Κ. Γυιόκα. Η συμμαχία του Φιλίππου Ε' μετά του Αννίβα κατα της Ρώμης (διάλεξις)
Authors: Κανατσούλης Δημήτριος
Published: February 2016

No abstract
Αρχιερατική επιστολή και αι προς Σέρβους σχέσεις της ελληνικής εκκλησίας
Authors: Κεραμόπουλλος Α. Δ.
Published: February 2016

No abstract
Ιωάννης Ν. Παπαφής
Authors: Λέτσας Αλέξανδρος Ν.
Published: February 2016

No abstract
Μ. Μαραβελάκη - Α. Βακαλοπούλου, Aι προσφυγικαί εγκαταστάσεις εν τη περιοχή Θεσσαλονίκης.
Authors: Λαούρδας Βασίλειος
Published: February 2016

No abstract
Stilpon Ρ. Kyriakides, The northern ethnological boundaries of Hellenism
Authors: Λαούρδας Βασίλειος
Published: February 2016

No abstract
Ιωάννου Σωτ. Νοτάρη, Παύλος Μελάς, βιογραφία
Authors: Λαούρδας Βασίλειος
Published: February 2016

No abstract
Οι "χαλασμοί" της Σελίτσης (Ερατύρας)
Authors: Γιομπλάκης Αθανάσιος
Published: February 2016

No abstract 
Ο Όσιος Θεοφάνης ο Νέος: (ο εξ Ιωαννίνων πολιούχος της Μακεδονικής Ναούσης, η ίδρυσις της πόλεως και η καταγωγή των κατοίκων)
Authors: Χιονίδης Γεώργιος Χ.
Published: February 2016

No abstract 
Δημοτικά τραγούδια του Μακεδονικού Αγώνα
Authors: Πετρόπουλος Δημήτριος Α.
Published: February 2016

No abstract 
Το οδοιπορικόν ενός Ιησουΐτου Ιεραποστόλου εις την "Ελλάδα" κατά το 1712-1714: (χρονικόν του βίου του ελληνικού λαού εις την Κωνσταντινούπολιν, Σμύρνην, Μακεδονίαν, και τας νήσους του Αιγαίου)
Authors: Τσούρκας Κλεόβουλος Δ.
Published: February 2016

No abstract 
Todesgedicht über Ioannes Aitolos aus dem Jahre 1811
Authors: Füves Ödön
Published: February 2016

No abstract 
Το οδικό δίκτυο της Ανατολικής Μακεδονίας από τα αρχαϊκά χρόνια ως τη ρωμαϊκή κατάκτηση
Authors: Σαμσάρης Δημήτριος Κ.
Published: February 2016

No abstract
Εκ της αρχαίας Βεροίας
Authors: Ρωμιοπούλου Αικ. , Τουρατσόγλου Ιωαν.
Published: February 2016

No abstract
"Θραξ Ιππεύς", "Πρωτοβούλγαροι" και παράδειγμα προς αποφυγήν
Authors: Πέτσας Φώτιος Μ.
Published: February 2016

No abstract
Ю. B. Эвaнгeлoпулoc, Лeкcичecкиe Ocoбeннocти нoвoгрeуecкoгo языкa B Эaпaднoй Maкeдoнии. Maтeриaл для диaлeктнoгo cлoвaря [Λεξιλογικές ιδιομορφίες της νεοελληνικής γλώσσας στη Δυτική Μακεδονία. Υλικό για διαλεκτολογικό λεξικό]
Authors: Συμεωνίδης Χ. Π.
Published: February 2016

No abstract

 
Ιωάν. Κ. Βασδραβέλλη, Αρματολοί και Κλέφτες εις την Μακεδονίαν
Authors: Παπουλίδης Κωνστ. Κ.
Published: February 2016

No abstract
Κατάλογος λειτουργικών ειληταρίων της Ιεράς Μονής Μεγίστης Λαύρας
Authors: Λαυριώτης Χρυσόστομος
Published: February 2016

No abstract
Κατάλογος λειτουργικών ειληταρίων της Ιεράς Μονής Βατοπεδίου
Authors: Πολίτης Λίνος
Published: February 2016

No abstract
Μια εικόνα του οσίου Νικάνορος
Authors: Συνδίκα-Λαούρδα Λουίζα
Published: February 2016

No abstract
Ιστορικαί διηγήσεις διάφοροι
Authors: Βασδραβέλλης Ι. Κ.
Published: February 2016

No abstract
Γ. Ι. Θεοχαρίδου, Σύντομος ιστορία του Αγίου Όρους
Authors: Λαούρδας Βασ.
Published: February 2016

No abstract
Γεωργίου Σπ. Πάλλα και Παναγιώτου Φιλ. Ζιώτα, Ο καπετάν Άγρας και ο Μίγκας (ιστορικόν δράμα και αφήγημα)
Authors: Λαούρδας Βασ.
Published: February 2016

No abstract
Βιβλιοθήκη της Βυζαντινής Θεσσαλονίκης. 1, Ιωάννου Αναγνώστου, Διήγησις περί της τελευταίας αλώσεως της Θεσσαλονίκης, Μονωδία επί τη αλώσει της Θεσσαλονίκης. Εισαγωγή, κείμενο, μετάφραση, σχόλια Γιάννη Τσάρα
Authors: Λαούρδας Βασ.
Published: February 2016

No abstract
Osteuropa Handbuch, Jugoslawien. In Zusammenarbeit mit zahlreichen Fachgelehrten, herausgegeben von Werner Markert
Authors: Λαούρδας Βασ.
Published: February 2016

No abstract
Αθανασίου Σουλιώτη-Νικολαΐδη, Ο Μακεδονικός Αγών. Η "Οργάνωσις Θεσσαλονίκης" 1906-1908, Απομνημονεύματα. Πρόλογος Σοφίας Αθ. Σουλιώτη, Εισαγωγή Διογένη Ξαναλάτου
Authors: Λαούρδας Βασ.
Published: February 2016

No abstract