bluuebunny/crossref_metadata_2025 huggingface dataset:
Dalla coppia alla famiglia
Authors: Milanesi Paolo
Published: July 2021

L'autore prende spunto dai lavori del Gruppo di Losanna per sostenere la tesi della polaritŕ duale quale ambito specie-specifico del divenire dell'essere umano. Questa tesi viene esposta nella cornice epistemologica della complessitŕ. Secondo l'autore la differenziazione tra duale, triadico o multi personale rappresenta un falso problema: l'ambiente č normalmente multiforme e variegato, ma il rapporto con l'Io-soggetto č sempre duale, nella misura in cui il contesto diventa unificato nella percezione gestaltica di un insieme di piů individui quale altro polo dell'interazione. L'individuo puň entrare in rapporto con il gruppale o il multiforme, ma sempre e soltanto attraverso una polaritŕ che riduce gli elementi a due: io-altro/i. Viene poi approfondita la comprensione del divenire dell'uomo alla nascita di un figlio, sottolineando il delicato passaggio dalla coppia alla coppia genitoriale e poi alla famiglia. L'articolo si conclude con una breve elencazione di alcuni possibili significati dell'investimento che la coppia coniugale/genitoriale attua verso il proprio figlio.
Strategies for Managing Marine Disease
Authors: Glidden Caroline Kate , Field Laurel C. , Bachhuber Silke , Hennessey Shannon M. , Cates Robyn , Cohen Lesley , Crockett Elin , Degnin-Warner Michelle , Feezell Maya K. , Fulton-Bennett Heather K. , Pires Devyn , Poirson Brittany N. , Randell Zachary H. , White Erick , Gravem Sarah A.
Published: July 2021

The incidence of emerging infectious diseases (EIDs) has increased in wildlife populations in recent years and is expected to continue to increase with global change. Marine diseases in particular are relatively understudied compared to terrestrial disease, but they can disrupt ecosystem resilience, cause economic loss, or threaten human health. While there are many existing tools to combat the direct and indirect consequences of EIDs, these management strategies are often insufficient or ineffective in marine habitats compared to their terrestrial counterparts, often due to fundamental differences in marine and terrestrial systems. Here, we first illustrate how the marine environment and marine organism life history present challenges or opportunities for wildlife disease management. We then assess the application of common disease management strategies to marine versus terrestrial systems to identify those that may be most effective for marine disease outbreak prevention, response, and recovery. Finally, we recommend multiple actions that will enable more successful management of marine wildlife disease emergencies in the future. These include prioritizing marine disease research and understanding its links to climate change, preventatively increasing marine ecosystem health, forming better monitoring and response networks, developing marine veterinary medicine programs, and enacting policy that addresses marine and other wildlife disease. Overall, we encourage a more proactive rather than reactive approach to marine conservation in general and to marine wildlife disease in particular and emphasize that multi-disciplinary collaborations are key to managing marine wildlife health.
INVESTIGATING THE RELATIONSHIPS BETWEEN EXPRESSED CANCER RELATED GENES AND SURVIVAL OF PATIENTS WITH BREAST CANCER
Authors: Nworah Chinenye , Sule Bashir
Published: July 2021

Cancer stem cells are regulated by complex interactions with the components of the tumor microenvironment through networks of Cytokins and growth factors. These interactions are mediated by group of proteins and microRNAs (miRs), which are expressed or repressed. These expression levels are critical for cancer stem cell formation and expansion, enabling the promotion of tumor cell proliferation and migration, as well as for the survival of cancer recurrence and patient survival. Micro array and RNA deep sequencing (RNA-seq) provide tools with ability to generate transcriptome information, deciphering global gene expression patterns and quantifying a large dynamic range of expression levels. In this study 94 breast cancer patients were investigated based on miR and mRNA expression levels in which WDR1, APC and AKAP13 genes were identiﬁed as genes that play important role in the survival of patients and these genes differed signiﬁcantly with respect to survival of patients. We used the Pearson correlation to identify the over-expressed and under-expressed genes. We demonstrated that parametric survival models can be used to model outcomes for breast cancer, and for our dataset the log-normal model demonstrated the best ﬁt compared to other parametric models. Through the use of log-normal model, we examined how each of the identiﬁed genes inﬂuence the survival of breast cancer patients.
NUTRITIONAL STATUS OF ADOLESCENTS OF DANKANDE COMMUNITY OF KADUNA METROPOLIS
Authors: Abdullahi A. , Anigo M. K. , Owolabi A. O. , Alhassan U. , Sallau A. B. , Awal M. I. , Abubakar Y. S. , Saliu M. A. , Hassan S. M. , Jajere U. M. , Luka J.
Published: July 2021

Studies on the nutritional status of adolescents in Dankande community of Kaduna metropolis were carried out. Adolescence is a period between 10 to 19 years of age. This period is a critical period where a healthy diet is needed for proper growth, development, academic performances and human capital development. A validated semi-structured questionnaire was used to assessed socio-demographic characteristic of the adolescent caregivers and dietary pattern of the adolescent while weight, height and BMI were used to assess the anthropometry indices of adolescent. 37.2% of adolescents were between age 10-14 years while 62.8% were between 15-19 years. Also, 5.1% of the adolescents were married, 88.5 were single and 6.4% windowed. (19.2%) of adolescents has no formal education, (2.6%) completed primary school, (29.5%) uncompleted primary school, (2.6%) completed Junior Secondary School, (19.2%) uncompleted Junior Secondary School, while (1.3%) completed Senior Secondary and (25.6%) did not complete Senior Secondary respectively.

However, on average (35.9%) of adolescent were dieting and (64.1%) were not dieting while (32.1%) were concerned about their weight and (67.9%) were not concerned about their weight. Few adolescents were losing control of their weight (24.4%) while the majority had their weight in check (75.6%), they engaged in physical activity (85.9%), while many adolescents spent more than two hours per day watching tv/games (69.2%).  17.9% engage in smoking while (5.1%) are involved in drinking alcohol, beer or wine. The nutritional status of adolescents of Dankande community of Kaduna state (56.4%) is good when compared with the national average
ASPECTOS AVALIATIVOS DO BASQUETEBOL NA ESCOLA
Authors: Almeida Lima George
Published: July 2021

Por muito tempo a educação física padronizou seu processo de avaliação, mensurando e comparando resultados em uma dimensão mecânica, biológica e fisiológica. Em muitos casos, alunos que não detinham habilidades suficientes para realizarem os procedimentos direcionados pelo professor acabavam excluídos pelos próprios colegas ou até se auto-excluindo devido a sua exposição nas aulas. Desta forma, faz-se necessária a compreensão das transformações da avaliação na escola, sendo entendida como um recurso metodológico. O presente trabalho objetiva analisar o processo avaliativo da educação física e especificamente do basquetebol na escola, além de compreender as dimensões da avaliação da educação física escolar e do basquete. A metodologia utilizada foi à revisão bibliográfica, onde foram analisadas obras relevantes que tratam da temática em questão. O basquetebol é uma prática cultural humana, por isso, deve estar presente na educação física escolar, e este conteúdo deve ser avaliado em uma perspectiva ampla, não se restringindo a avaliação motora. Deve-se levar em consideração o desenvolvimento integral do aluno e para isso, a avaliação deve ser formativa, ou seja, o aluno deve ser avaliado durante todo o seu percurso escolar, para que tenha consciência dos seus erros e acertos. Deste modo, infere-se que o professor possa avaliar o conteúdo basquetebol em três dimensões; conceitual, procedimental e atitudinal, fazendo com que os alunos possam fruir, refletir, saber fazer e saber conviver, para que atuem socialmente de maneira crítica e reflexiva em todos os segmentos de sua vida.
EFEITOS DO TREINAMENTO DE FORÇA NO DESEMPENHO DE PRATICANTES DE NATAÇÃO: UMA REVISÃO BIBLIOGRÁFICA DESCRITIVA
Authors: Pereira de Brito Alcides , Jeci de Holanda Francisco
Published: July 2021

O objetivo do presente estudo foi revisar na literatura o efeito do programa de treinamento força (TF) no desempenho de praticantes de natação. Um estudo descritivo em com abordagem qualitativa sendo uma revisão bibliográfica na qual consideraram pesquisa de estudos nas bases de dados: Scielo, Lilacs e Pubmed, selecionados 17 estudos para suportar o apanhado de evidências da pesquisa. Tendo critérios de inclusão, seleção por título, sequencialmente pela importância do artigo, relevância dos resultados, metodologia adotada. E como parâmetros de exclusão foram: não preencheram os critérios de elegibilidade, temas fora do objetivo e revisão bibliográfica. A análise dos estudos sobre TF para o desempenho de praticantes de natação é um assunto que vem despertando um crescente interesse na comunidade científica, existindo fatores primordiais que podem ser desenvolvidos com o TF e utilizados dentro na natação com vertentes para adaptações neuromusculares como ativação e potencia muscular, morfológicas como aumento da sessão transversa ocasionado melhora do desempenho do nadador. Dessa maneira, a partir da classificação e da seleção e leitura dos trabalhos científicos, evidenciou-se que o TF para o desempenho de praticantes de natação mostra-se capaz de proporcionar alterações significativas no desempenho mostrando assim a importância do TF na melhora do desempenho de nadadores.
VIVÊNCIA DE ATIVIDADES FÍSICAS E AQUISIÇÃO DE HABILIDADES MOTORAS
Authors: Wallan Tertuliano Ivan , Oliveira Vivian de , De Oliveira Castro Henrique
Published: July 2021

O presente estudo teve o objetivo de organizar conteúdos sobre a contribuição da vivência de atividades físicas para aquisição e melhoria das habilidades motoras fundamentais e, consequentemente, com o desenvolvimento motor de crianças com idade entre 6 e 10 anos. Para isso, realizou-se uma revisão bibliográfica, do tipo narrativa, com o uso de artigos publicados sobre a temática, por meio de descritores específicos, tendo como base para coleta de informações as bases: PUBMED, LILACS, Scielo e Google Acadêmico, assumindo textos publicados entre 2009 e 2020. A consulta às bases de dados ocorreu em janeiro de 2021. Utilizou-se dos seguintes descritos para busca: Desenvolvimento motor, habilidade motora, criança e atividade física, em português e em inglês. Os estudos que fizeram parte desta revisão sugerem que a prática de atividade física auxilia o processo de aquisição e refinamento das habilidades motoras fundamentais de crianças com idade entre 6 e 10 anos de idade, mas que isso só é possível se houver intervenção motora adequada, organizada e sistematizada, sempre com o acompanhamento de um Profissional de Educação Física. Assim, pode-se considerar que os Profissionais de Educação Física devem propiciar atividades com objetivos definidos e direcionados para o desenvolvimento de aspectos específicos do movimento que o aluno aprenderá.
Balanced development of tourism industry in Dnipropetrovsk and Zaporizhzhia regions
Authors: Yukhnovska Yu.
Published: July 2021

The state of balanced development of the tourism industry potential in Dnipropetrovsk and Zaporizhzhia regions, and the latest publications of scientists and specialists concerning this problem are investigated; the social subsystem of Dnipropetrovsk and Zaporizhia regions for identification the balance and impact of indicators on the development of the tourism industry in the country’s regions, such as the dynamics of the labor market in Ukraine, Dnipropetrovsk and Zaporizhia regions (employment rate; unemployment rate; average number of full-time employees; the level of average monthly wages) is analyzed; the ecological subsystem of balanced development of the tourism industry potential (analysis of capital investments in environmental protection by types of environmental measures; current expenditures for environmental protection) is analyzed; the main negative ecological and sociocultural consequences of the tourism industry in the regions of Ukraine are revealed in this paper. The main problems and the influence of various factors on the balanced development of the tourism industry potential are identified. Negative consequences of tourism impact on ecological and social subsystems are revealed. It is determined that while developing economic instruments for the formation of balanced development of the country’s tourism industry potential special attention should be paid to investment, credit, tax and budgetary and organizational and structural aspects. The direct and indirect influence of the tourism industry on the regions economy is revealed. The dynamics of the tourism industry in Dnipropetrovsk and Zaporizhzhia regions of Ukraine is analyzed. It is determined that the balanced development of the tourism industry potential in Dnipropetrovsk and Zaporizhzhia regions is influenced by natural-geographical, historical-cultural, economic, material-technical, demographic, social, political, legal and environmental factors. The factors that inhibit and negatively affect the balanced development of the tourism industry potential of Ukraine, which include outdated material and technical base, low level of tourism products competitiveness, low quality of services, technological backwardness, lack of proper tourist infrastructure are investigated and reflected in this research in detail.
Current state of voluntary medical insurance in Ukraine
Authors: Myhailyuk M. , Roman T. , Tanchak Ya.
Published: July 2021

The current state of voluntary health insurance in Ukraine is analyzed in this paper. The place of voluntary medical insurance in the insurance market of Ukraine is determined. The essence, purpose, objectives, features, advantages and disadvantages of voluntary health insurance as one of the funding sources for medical sector are considered as well. The programs under which voluntary health insurance is currently implemented are listed, these are mainly personal and corporate ones. The main tendencies are investigated, relative indicators of the functioning level of voluntary health insurance market are calculated. The problems of voluntary health insurance are identified and measures for such insurance development in Ukraine are proposed. Our investigation is devoted, particularly, to the identification of the main problems in the development of voluntary health insurance in Ukraine. The authors investigated the availability of voluntary health insurance for population, analyzed the state of industry reforming in a certain period and substantiated the consequences of the reform impact on the voluntary health insurance market in Ukraine. The dynamics of the health insurance market indicators is analyzed on the basis of the size of gross insurance premiums and payments, as well as the calculated indicator - the insurance payments coefficient. In particular, insurance payments for voluntary health insurance in the regional context, by regions in individual insurance companies for a certain period of time are analyzed. The method of compiling the rating of insurers on the basis of insurance premiums and payments is proposed. It is determined that the level of medical services is growing, as well as the trust in voluntary health insurance in Ukraine. The main problems of the voluntary health insurance system functioning are highlighted and recommendations for improving the quality and availability of health insurance in Ukraine are proposed. These recommendations take into account a set of economic, legal and social factors of the insurance market development. Measures for state authorized bodies and private insurance companies that provide the extension of voluntary health insurance in Ukraine are proposed.
Rezultati komparativnog pokusa suncokreta na lokacijama Koprivnica i Osijek
Authors: Međimurec Tatjana
Published: July 2021

Unazad nekoliko godina, na području sjeverozapadne Hrvatske (Međimurska, Varaždinska i Koprivničko-križevačka županija), povećava se zanimanje poljoprivrednih proizvođača za uzgojem suncokreta. Službenici Ministarstva poljoprivrede su 2020. godine proveli komparativni pokus na dvije lokacije: Koprivnica (Koprivničko-križevačka županija) i Osijek (Osječko-baranjska županija), u kojem je testirano 20 hibrida suncokreta. Cilj istraživanja bio je utvrditi razlike u ostvarenim urodima te fizikalnim i kemijskim svojstvima zrna. U Koprivnici, prosječan urod zrna je bio 3,970 t/ha, hektolitarska masa 43,5 kg/hl, masa 1000 zrna 54,10 g, a sadržaj ulja u suhoj tvari zrna 50,75%. U odnosu na Koprivnicu, u Osijeku je bio veći prosječan urod zrna (4,091 t/ha) i sadržaj ulja u suhoj tvari zrna (51,88%), a manja hektolitarska masa (43,4 kg/hl) i masa 1000 zrna (52,42 g). Uvjeti za uzgoj suncokreta na ispitivanim lokacijama se znatno razlikuju. Komparativni pokus se planira provesti i u naredne dvije godine s ciljem utvrđivanja adaptabilnosti i stabilnosti testiranih hibrida. Iz ovogodišnjih rezultata može se zaključiti da agroekološki uvjeti u sjeverozapadnoj Hrvatskoj omogućuju uzgoj suncokreta zadovoljavajuće razine uroda i kakvoće zrna.
Exploring Self-Care Strategies in Individuals with Low Literacy Type 2 Diabetes and Euglycemia
Authors: Casapulla Sharon L. , Dugan, MPH, DHSc, PA-C Joy , Reinig Emily , Shubrook Jay H. , Nicks Shannon E.
Published: July 2021

Purpose
This qualitative study utilizes the health belief model to explore how individuals with type 2 diabetes mellitus and low diabetes numeracy achieve and maintain good glycemic control.

Methods
Participants (n=10) participated in semi-structured interviews and completed the Patient Diabetes Knowledge Questionnaire, the Health Belief Questionnaire, and the Social Support Assessment Tool.

Results
Results indicate that participants had low levels of diabetes knowledge, high levels of perceived social support, and strong self-efficacy related to type 2 diabetes management, despite low numeracy. Self-designed routines mitigated potential educational, socioeconomic, and knowledge barriers. Self-efficacy and social support were strong protective factors.
The Effectiveness of Saltwater Gargling on the Prevention of Upper Respiratory Tract Infections
Authors: Lindsey II Tommy G. , Gillette Ben
Published: July 2021

Upper respiratory tract infections (URI) are prevalent in the United States. URIs can also be debilitating and costly. The most common etiology for an URI is viral, and there are currently no antiviral medications for the common cold. Therefore, cost-effective preventative measures are essential in the prevention of URIs. This literature review intends to compare the few studies evaluating the effectiveness of saltwater gargle for preventing URIs. The goals of this review include commenting on the potential for a saltwater gargle in preventing URIs, shortcomings of the few studies performed and recommendations for further research in evaluating saltwater gargle as an effective prevention method. This review looks explicitly at three studies evaluating the effectiveness of saltwater gargling and the prevention of URIs. Conclusions derived from this review include both physiological and clinical evidence of the potential for saltwater gargling in URI prevention. The first two studies demonstrate patient-derived evidence for saltwater gargling, potentially providing a decreased risk of URI when used preventatively. The third study demonstrates the potential for polymerase chain reaction (PCR) in evaluating the effectiveness of saltwater gargling in reducing the duration of illness. Additionally, in the wake of the COVID-19 pandemic, cost-effective treatment options targeting viral URIs, such as SARS-CoV-2, warrant further evaluation and discussion.
A polêmica sobre o conceito de terceirização e sua regulação
Authors: Dutra Renata , Filgueiras Vitor
Published: July 2021

Apesar de a terceirização ser objeto de grandes controvérsias, existe um consenso acerca do conceito que a define. O objetivo deste texto é problematizar esse consenso e apontar suas contradições, demonstrando que a precarização do trabalho relacionada à terceirização não é uma contingência, mas corolário da natureza dessa forma de contratação de trabalhadores, que reduz as chances de limitação da exploração do trabalho.

Palavras-chave: Terceirização, divisão do trabalho, precarização.
Germline GATA2 variant disrupting endothelial eNOS function and angiogenesis can be restored by c-Jun/AP-1 upregulation
Authors: Purgatorio Giulio , Piselli Elisa , Guglielmini Giuseppe , Falcinelli Emanuela , Bury Loredana , Di Battista Valeria , Pellanera Fabrizia , Milano Francesca , Matteucci Caterina , Mecucci Cristina , Gresele Paolo
Published: July 2021

GATA2 is a transcription factor with key roles in hematopoiesis. Germline GATA2 gene variants have been associated with several inherited and acquired hematologic disorders, including myelodysplastic syndromes. Among the spectrum of GATA2 deficiency- associated manifestations thrombosis has been reported in 25% of patients, but the mechanisms are unknown. GATA2 was shown to be involved in endothelial nitric oxide synthase (eNOS) regulation and vascular development. We assessed eNOS expression and angiogenesis in patients with GATA2 deficiency. Platelets and blood outgrowth endothelial cells (BOEC) from GATA2 variant carriers showed impaired NO production and reduction of eNOS mRNA and protein expression and of eNOS activity. GATA2 binding to the eNOS gene was impaired in BOEC from GATA2-deficient patients, differently from control BOEC. GATA2 deficiency BOEC showed also defective angiogenesis, which was completely restored by treatment with the NO-donor Snitroso- N-acetylpenicillamine (SNAP). Atorvastatin, but not resveratrol, largely restored eNOS expression, NO biosynthesis and neoangiogenesis in GATA2-deficient BOEC by a mechanism involving increased expression of the eNOS transcription factor AP-1/c-JUN, replacing GATA2 when the latter is inactive. Our results unravel a possible thrombogenic mechanism of GATA2 mutations, definitely establish the regulation of eNOS by GATA2 in endothelial cells and show that endothelial angiogenesis is strictly dependent on the eNOS/NO axis. Given the ability of atorvastatin to restore NO production and angiogenesis by GATA2-deficient endothelial cells, the preventive effect of atorvastatin on thrombotic events and possibly on other clinical manifestations of the syndrome related to deranged angiogenesis should be explored in patients with GATA2 deficiency in an ad hoc designed clinical trial.
Temperature Effect on the Physical Properties of Enamel Paint Layer on Cement Plaster
Authors: Kaiser Samiul , Kaiser Mohammad Salim
Published: July 2021

The heating effect on the stability and visual colour of enamel paint on cement plaster is evaluated through light intensity ratio of three primary colours (RGB). The painted cement plaster is isochronally heated in an electric resistance furnace at different temperatures for one hour. The investigation of optical images reveals that the original colour of the paint layer on the plaster samples remains more or less unchanged up to heating at 100°C. However, thermal degradation of the samples becomes evident in colour when they are heated beyond 200°C and at 350°C the colour becomes already burned. The microstructural images of the samples at room temperature show fine and uniform grains. But at higher heating condition the microstructure of the colour sample is characterized by coarsening grain. The colour of the heated samples are then studied through tristimulus colour ‘L*’, ‘a*’ ‘b*’ and ‘E*’ values which were analyzed and evaluated in MATLAB software. The results show that after 200°C the hunter ‘L*’ value starts to decrease greatly up to 250°C. The hunter ‘a*’ value shows an increasing trend up to 100°C and then begins to decrease until 200°C. After 200°C the same increasing character is showed till 300°C. The change of hunter ‘b*’ value remains insignificant up to 100°C and shows decreasing trend between 100°C-250°C range and an increase after 250°C up to 300°C. It is graphically shown that the proportion of all three colours decreases with the increasing temparature. The overall change of colour ‘E*’ occurs with increasing heating temperature due to moisture releasing, chemical changes and thermal degradation simulteneously. The thickness of enamel paint layer comply the above degradation by showing the nature of decresing trend.

Journal of Engineering Science 12(2), 2021, 103-108
Modified Dynamically-updated Weighted Opportunity Cost Based Algorithm for Unbalanced Transportation Problem
Authors: Jamali ARM Jalal Uddin , Mondal Ringku Rani
Published: July 2021

Recently, Weighted Opportunity Cost (WOC) based algorithms are developed for solving balanced Transportation Problems (TPs). The exceptionality of the WOC based approaches is to introduce supply and demand as weight factor to cost entries for the control of flow of allocations. But in the unbalanced TP, there exist a pitfall whenever balancing the TP with zero dummy transportation cost as done in existing classical approaches, so that the total cost is unaffected due to dummy transportations. A modified dynamically-updated weighted opportunity cost-based algorithm embedded on Least Cost Method (LCM) is proposed which is suitable for both balanced and unbalanced TPs. Numerical instances have been carried out to demonstrate the effectiveness and efficiency of the proposed method. It is observed that, the proposed modified dynamically-updated weighted opportunity cost-based algorithm sometimes outperforms for the LCM as well as the existing weighted opportunity cost-based algorithm in unbalanced TPs.

Journal of Engineering Science 12(2), 2021, 119-131
Efecto remediador de extractos de Sapindus saponaria sobre un suelo contaminado con gasoil a nivel de laboratorio
Authors: Marín Velásquez Tomás Darío , Arriojas Tocuyo Dany Day Josefina
Published: July 2021

Se evaluaron dos extractos de Sapindus saponaria como remediadores de un suelo contaminado con gasoil, a nivel de laboratorio. El suelo se contaminó con 100 ml de gasoil por kilogramo y se trató con extractos acuosos e hidroalcohólico en dosis de 50, 100 y 150 ml por kilogramo de suelo contaminado, con una muestra control por atenuación natural. El diseño fue completamente aleatorio con seis tratamientos, un bloque patrón, tres replicas por tratamiento y una variable respuesta (porcentaje de extraíbles con n-hexano, HEM), según norma EPA 9071b. Se tomaron muestras de cada unidad experimental a los 15, 30 y 45 días y se determinó el HEM. La prueba estadística fue ANDEVA factorial con criterios múltiples de Tukey y Dunnet y significancia α = 0,05 para establecer la influencia de los factores experimentales sobre la variable respuesta. Los extractos de S. saponaria tuvieron un efecto positivo, aumentando la eficiencia de remediación, respecto al control, de forma estadísticamente significativa, siendo el tratamiento con 150 ml de extracto hidroalcohólico el más eficiente con una remoción de 93.9% del gasoil, aun cuando estadísticamente no hubo diferencia entre los extractos y los factores que influyeron fueron la cantidad de extracto y el tiempo de la prueba.
nutria marina (Lontra felina) en los Andes del sur del Perú
Authors: Ugarte Núñez Joaquín Antonio
Published: July 2021

La nutria marina, gato marino o chungungo (Lontra felina) es considerada virtualmente una especie exclusiva marina con una preferencia de hábitat rocosos de litoral en la costa pacíﬁca de Perú y hasta Tierra del Fuego al sur de Chile y la Isla de los Estados en el sur de Argentina. En esta nota cientíﬁca se presentan registros ﬂuviales de la nutria marina. En el río Cotahuasi (cuenca del río Ocoña) se tiene un registro hasta la localidad de Sipia, a 171 Km del litoral y a 1 994 m de altitud. En la cuenca del río Colca (cuenca Majes), el registro más alejado es en la laguna Mamacocha en la provincia de Caylloma, a 157 Km del mar a una altitud de 1 702 m.Se presentan además otros registros directos e indirectos hasta la desembocadura de estas cuencas. El registro de esta especie en dos de los ríos más grandes del suroeste de Perú y no en los demás (departamentos de Moquegua y Tacna), posiblemente se deba a la conﬁguración extremadamente encañonada, lo que puede representar un refugio para esta especie amenazada, además de tener una abundante oferta alimenticia. Se considera necesario incluir acciones de conservación en la distribución ﬂuvial de la nutria de mar, debido a que actividades como la construcción  de presas, afectarían signiﬁcativamente su presencia en este espacio y hábitat de su distribución, en gran medida desconocido.
LIFE EXPECTANCY IN THE SIBERIAN FEDERAL DISTRICT AND IN THE IRKUTSK REGION IN 1990-2018: TRENDS AND PECULIARITIES
Authors: Leshchenko Ya. A. , Lisovtsov A. A.
Published: July 2021

Introduction: Life expectancy is widely used as an indicator of socio-economic development of territories and public health in general. Aim: To study secular trends and peculiarities of life expectancy in the Irkutsk region and in the Siberian Federal District from 1990 to 2018. Methods: Data on life expectancy for all regions included in the Siberian Federal District (Siberian FD) were obtained from Rosstat and from the Center for Demographic Research of the Russian School of Economics. Linear regression was applied to study trends in life expectancy. Results: There was a consistent improvement in the demographic situation in Russia 2006 to 2018 caused by decreasing mortality and increasing life expectancy. On the national level, life expectancy increased from 66.7 to 72.9 years. The corresponding data for Siberian FD were 64.6 and 70.7 years while in the Irkutsk region the increase was from 62.9 to 69.3 years. Similar patterns were observed in all FDs, but the improvements in the demographic indicators were less pronounced in the Eastern regions of the country. Life expectancy in the Irkutsk region and the Siberian FD remained lower compared to other FDs except for the Far Eastern District over the study period. Significant linear increase in life expectancy was observed in regions with coefficient of determination ranging from 0.960-0.989, p < 0.001 for all tests. In 2018, the annual increase in life expectancy dropped from 0.3-0.9 to 0.1-0.2 years. Conclusions: Our findings suggest less favorable state of public health in the Siberian FD and in the Irkutsk region compared to the other FDs and the national average. These findings are in line with the conclusions from earlier studies performed by the authors about lower quality of the life of the population in Siberia than in Russia in general.
An Overview of the Korean Intermittent Exotropia Multicenter Study by the Korean Association for Pediatric Ophthalmology and Strabismus
Authors: Kim Dae Hee , Baek Seung-Hee , Choi Hee-young , Choi Dong Gyu , Lee Dong Cheol , Lee Se-Youp , Lim Han Woong , Lim Hyun Taek , Ryu Won Yeol , Yang Hee Kyung , Lim Key Hwan ,   for Korean Association for Pediatric Ophthalmology and Strabismus
Published: July 2021

The Korean Intermittent Exotropia Multicenter Study (KIEMS), which was initiated by the Korean Association of Pediatric Ophthalmology and Strabismus, is a collaborative multicenter study on intermittent exotropia in Korea. The KIEMS was designed to provide comprehensive information, including subjective and objective findings of intermittent exotropia in a large study population. A total of 65 strabismus specialists in 53 institutions contributed to this study, which, to date, is one of the largest clinical studies on intermittent exotropia. In this article, we provide a detailed methodology of the KIEMS to help future investigations that may use the KIEMS data.
SELECTION OF THE RIGHT MARKETPLACE FOR SALE OF ORNAMENTAL PLANTS USING ANALYTICAL HIERARCHY PROCESS (AHP) METHOD
Authors: Hidayat HR Syarif , Susanti Melan , Rahmawati Mari
Published: July 2021

Basically, each marketplace has its own market, therefore as a seller who will start an online business, especially those who use the marketplace, they must know which marketplace is right to start their online business according to what category of goods to sell. This research is needed to help business people, in this case ornamental plant traders, choose the right marketplace for their online business activities. Decision Support System (DSS) is a computer-based system used to help make decisions from structured and semi-structured problems. Analytical Hierarchy Process (AHP) is a method that can be used to select from the specified criteria. This method can simplify the criteria that are considered in making decisions for marketplace selection to be simpler and easier to understand. The results of the study show that the decisions made using the AHP method are very effective, and are expected to help make objective decisions. After processing data and analyzing respondent data, with the criteria for the number of visitors, transaction system, features, and searc engine optimization (SEO), it was found that Lazada (0.428) has the highest priority, Tokopedia (0.235) with second priority, Shopee (0.204) with priority third, and Bukalapak (0.133) with the fourth priority
APRIORI ALGORITHM FOR DETERMINING THE DEMAND LEVEL OF STATIONARY PT. MAIN GAFA INDONESIA
Authors: Wahyuni Sri , Dari Wulan , Prahartiwi Lusa Indah
Published: July 2021

PT Gafa Utama Indonesia is one company that provides services in teaching and writing. Until now, PT Gafa Utama Indonesia already has 30 well-known branches in Jabodetabek. In the teaching and learning process, Gafa needs some stationery and teaching aids. The high demand for office stationery, and the mismatch of inventory in the warehouse, affects the fluency in the teaching and learning process. The data used in this study is the report data on the demand for office stationery for the period January-December 2018. This study uses a priori algorithm method and assessment with tanagra tools. The results of manual calculations with Microsoft Excel are the same as those using the tanagra tool. The final result shows the 2 items with the most demand, namely an eraser and a sharpener with at least 50% support, and 50% confidence. These results can be used as a reference for PT Gafa Utama Indonesia in the supply of office stationery
Investigating the Role of Management Ownership in Revealing Firm Value
Authors: Zuhriansyah Deddy Mendai , Santoso Aprih
Published: July 2021

This study aims to analyze the role of management ownership in moderating the effect of total asset turnover on firm value. The data is taken from the financial statements and annual reports of manufacturing companies listed on the Indonesia Stock Exchange for the period 2017 – 2019. Using purposive sampling, 27 companies were selected as research samples. The data was processed by multiple regression analysis using the help of the IBM SPSS Statistic 25 application. The results showed that TATO had no significant effect on firm value. The results of testing the moderating variable show that management ownership does not moderate the effect of TATO on firm value

Keywords: TATO, firm value, finance, ratio
Lecture Notes on Inverse Theory
Authors: Fichtner Andreas
Published: July 2021

Inverse theory is the art of inferring properties of a physical system from observations. It is used to transform recordings of wavefields into estimates of medium properties in seismic tomography, medical imaging and nondestructive testing. It serves to constrain the distribution of density inside the Earth from gravity measurements, and to obtain probabilities of life on exoplanets based on telescope observations of electromagnetic spectra. The list of examples is endless. The primary goal of these lecture notes is to equip the reader with a solid theoretical background and with an extensive toolbox that can be used to solve real-world inverse problems. A central theme is the recognition that the best theory or the best method do not exist. A good solution strategy is application- and data-specific, and so these notes are intended to help with making a reasonable choice.
Perilaku Waspada Stroke Pengidap Hipertensi
Authors: Lusiana Merry , Nuryati Tati , Muhaimin Toha , Edison Rizki Edmi
Published: July 2021

Introduction: Non infectious disease is a major health problem especially in developing countries. Among those, stroke always be the leading one that occurs followed by health burden.  Some factors in increasing of mortality and disability due to stroke are lack of understanding of risk factors and awareness to early signs especially among people with hypertension. If the factors those influence the knowledge, awareness, and others stroke alert behaviors are known, promotive or prevention acts could be done by health workers. Aims: The aim of this study is to find out the stroke alert behavior among them that conducted at Puskesmas Cengkareng of West Jakarta on July and August 2020. Method: 116 patients were participated to fill the questionnaire and analyzed with cross-sectional design. Results: Our study revealed that knowledge, perception of utility, and perception to level of disease severity is the most influenced factor to stroke alert behavior.
Persepsi Mahasiswa Tahap Profesi Kedokteran terhadap Interprofessional Education
Authors: Akbar Resti Rahmadika
Published: July 2021

Introduction: The introduction of the concept of collaborative health education that has been launched by WHO aims to improve health services. Collaborative media initiated by WHO is Interprofessional Education (IPE). Professional stage students are expected to cooperate with other health professions. A positive perception of IPE acceptance is expected to be taken into consideration by institutions for the development of the IPE concept at the Faculty of Medicine at Universitas Baiturrahmah. Aims: The purpose of this study was to determine perceptions of medical professional stage students towards IPE. Method: This type of research is quantitative with a descriptive analysis design with a cross-sectional approach. The research sample was used in consecutive sampling. Retrieval data with a modified IEPS (Interprofessional Education Perception Scale) questionnaire. Results: The results showed the reliability of the IEPS questionnaire 0.890. The modified IEPS questionnaire has 12 statements. The majority of the perception of medical professional stage students is positive 92.3%. The subcategory of competence and autonomy are good at 89.7%, the need to work together is good at 97.4% and perceptions about collaboration are good at 89.7%. Conclusion: The majority of students' perceptions of interprofessional education are good and need strategies and communication from educational institutions and teaching hospitals in its implementation.
Finite-Time Synchronization Between Two Different Chaotic Systems by Adaptive Sliding Mode Control
Authors: Tino Nipaporn , Niamsup Piyapong
Published: July 2021

The finite-time chaos synchronization between two different chaotic systems with uncertain parameters and external disturbances is studied. A new and improved adaptive fast nonsingular terminal sliding mode control (ANFTSM) has been designed for a fast rate convergence of tracking error to zero in finite time. The effectiveness of the proposed control method is shown in simulation results.
Identification of Novel Variants in Cleft Palate-Associated Genes in Brazilian Patients With Non-syndromic Cleft Palate Only
Authors: Machado Renato Assis , Martelli-Junior Hercílio , Reis Silvia Regina de Almeida , Küchler Erika Calvano , Scariot Rafaela , das Neves Lucimara Teixeira , Coletta Ricardo D.
Published: July 2021

The identification of genetic risk factors for non-syndromic oral clefts is of great importance for better understanding the biological processes related to this heterogeneous and complex group of diseases. Herein we applied whole-exome sequencing to identify potential variants related to non-syndromic cleft palate only (NSCPO) in the multiethnic Brazilian population. Thirty NSCPO samples and 30 sex- and genetic ancestry-matched healthy controls were pooled (3 pools with 10 samples for each group) and subjected to whole-exome sequencing. After filtering, the functional affects, individually and through interactions, of the selected variants and genes were assessed by bioinformatic analyses. As a group, 399 variants in 216 genes related to palatogenesis/cleft palate, corresponding to 6.43%, were exclusively identified in the NSCPO pools. Among those genes are 99 associated with syndromes displaying cleft palate in their clinical spectrum and 92 previously related to cleft lip palate. The most significantly biological processes and pathways overrepresented in the NSCPO-identified genes were associated with the folic acid metabolism, highlighting the interaction between LDL receptor-related protein 6 (LRP6) and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) that interconnect two large networks. This study yields novel data on characterization of specific variants and complex processes and pathways related to NSCPO, including many variants in genes of the folate/homocysteine pathway, and confirms that variants in genes related to syndromic cleft palate and cleft lip-palate may cause NSCPO.
A Covalent Calmodulin Inhibitor as a Tool to Study Cellular Mechanisms of K-Ras-Driven Stemness
Authors: Okutachi Sunday , Manoharan Ganesh Babu , Kiriazis Alexandros , Laurini Christina , Catillon Marie , McCormick Frank , Yli-Kauhaluoma Jari , Abankwa Daniel
Published: July 2021

Recently, the highly mutated oncoprotein K-Ras4B (hereafter K-Ras) was shown to drive cancer cell stemness in conjunction with calmodulin (CaM). We previously showed that the covalent CaM inhibitor ophiobolin A (OphA) can potently inhibit K-Ras stemness activity. However, OphA, a fungus-derived natural product, exhibits an unspecific, broad toxicity across all phyla. Here we identified a less toxic, functional analog of OphA that can efficiently inactivate CaM by covalent inhibition. We analyzed a small series of benzazulenones, which bear some structural similarity to OphA and can be synthesized in only six steps. We identified the formyl aminobenzazulenone1, here named Calmirasone1, as a novel and potent covalent CaM inhibitor. Calmirasone1 has a 4-fold increased affinity for CaM as compared to OphA and was active against K-Ras in cells within minutes, as compared to hours required by OphA. Calmirasone1 displayed a 2.5–4.5-fold higher selectivity for KRAS over BRAF mutant 3D spheroid growth than OphA, suggesting improved relative on-target activity. Importantly, Calmirasone1 has a 40–260-fold lower unspecific toxic effect on HRAS mutant cells, while it reaches almost 50% of the activity of novel K-RasG12C specific inhibitors in 3D spheroid assays. Our results suggest that Calmirasone1 can serve as a new tool compound to further investigate the cancer cell biology of the K-Ras and CaM associated stemness activities.
Precision Medicine Gains Momentum: Novel 3D Models and Stem Cell-Based Approaches in Head and Neck Cancer
Authors: Affolter Annette , Lammert Anne , Kern Johann , Scherl Claudia , Rotter Nicole
Published: July 2021

Despite the current progress in the development of new concepts of precision medicine for head and neck squamous cell carcinoma (HNSCC), in particular targeted therapies and immune checkpoint inhibition (CPI), overall survival rates have not improved during the last decades. This is, on the one hand, caused by the fact that a significant number of patients presents with late stage disease at the time of diagnosis, on the other hand HNSCC frequently develop therapeutic resistance. Distinct intratumoral and intertumoral heterogeneity is one of the strongest features in HNSCC and has hindered both the identification of specific biomarkers and the establishment of targeted therapies for this disease so far. To date, there is a paucity of reliable preclinical models, particularly those that can predict responses to immune CPI, as these models require an intact tumor microenvironment (TME). The “ideal” preclinical cancer model is supposed to take both the TME as well as tumor heterogeneity into account. Although HNSCC patients are frequently studied in clinical trials, there is a lack of reliable prognostic biomarkers allowing a better stratification of individuals who might benefit from new concepts of targeted or immunotherapeutic strategies. Emerging evidence indicates that cancer stem cells (CSCs) are highly tumorigenic. Through the process of stemness, epithelial cells acquire an invasive phenotype contributing to metastasis and recurrence. Specific markers for CSC such as CD133 and CD44 expression and ALDH activity help to identify CSC in HNSCC. For the majority of patients, allocation of treatment regimens is simply based on histological diagnosis and on tumor location and disease staging (clinical risk assessments) rather than on specific or individual tumor biology. Hence there is an urgent need for tools to stratify HNSCC patients and pave the way for personalized therapeutic options. This work reviews the current literature on novel approaches in implementing three-dimensional (3D) HNSCCin vitroandin vivotumor models in the clinical daily routine. Stem-cell based assays will be particularly discussed. Those models are highly anticipated to serve as a preclinical prediction platform for the evaluation of stable biomarkers and for therapeutic efficacy testing.
Melatonin Protects Against Mdivi-1-Induced Abnormal Spindle Assembly and Mitochondrial Superoxide Production During Porcine Oocyte Maturation
Authors: Yang Seul-Gi , Joe Seung-Yeon , Bae Jin-Wook , Heo Gyeong-Deok , Park Hyo-Jin , Koo Deog-Bon
Published: July 2021

Mitochondrial division inhibitor 1 (Mdivi-1) reportedly provides a close connection between oocyte maturation and mitochondrial function in pigs. N-acetyl-5-methoxy-tryptamine (melatonin) is known to be a representative antioxidant with the ability to rehabilitate meiotic maturation of porcine oocytes. However, the ability of melatonin to recover Mdivi-1-mediated disruption of spindle formation during meiotic maturation of porcine oocytes during in vitro maturation (IVM) has not been studied. Here, we first investigated changes in mitochondrial length, such as fragmentation and elongation form, in mature porcine oocytes during IVM. Mature oocytes require appropriate mitochondrial fission for porcine oocyte maturation. We identified a dose-dependent reduction in meiotic maturation in porcine oocytes following Mdivi-1 treatment (50, 75, and 100 μM). We also confirmed changes in mitochondrial fission protein levels [dynamin-related protein 1 phosphorylation at serine 616 (pDRP1-Ser616) and dynamin-related protein 1 (DRP1)], mitochondrial membrane potential, and ATP production in 75 μM Mdivi-1-treated oocytes. As expected, Mdivi-1 significantly reduced mitochondrial function and DRP1 protein levels and increased spindle abnormalities in porcine oocytes. In addition, we confirmed that melatonin restores abnormal spindle assembly and reduces meiotic maturation rates by Mdivi-1 during porcine oocyte maturation. Interestingly, the expression levels of genes that reduce DNA damage and improve tubulin formation were enhanced during porcine meiotic maturation. Taken together, these results suggest that melatonin has direct beneficial effects on meiotic maturation through tubulin formation factors during porcine oocyte maturation.