bluuebunny/crossref_metadata_2025 huggingface dataset:
Autopercepción de la maloclusión y calidad de vida en pacientes adolescentes y adultos jóvenes que asisten a la Facultad de Odontología de la Universidad Nacional del Nordeste
Authors: Meza Edna Y. , Lytwing Patricia F. , Rosende María N. , Olivera Paola B.
Published: December 2023

La autopercepción del paciente juega un papel muy importante en la decisión del tratamiento y en el juicio de la estética dental del profesional. Es lógico suponer que mientras más visibles sean las alteraciones pueden provocar una mayor aversión, afectando e interfiriendo en su interés por corregir la alteración. Por ello el objetivo del presente trabajo fue analizar la autopercepción y la calidad de vida en la salud oral en adolescentes y adultos jóvenes. Con el fin de alcanzar los objetivos planteados se realizó un estudio observacional, descriptivo de corte transversal. La población de estudio estuvo constituida por los pacientes que asistieron a las clínicas rehabilitadora I y II de la de la Facultad de Odontología de la UNNE. Se consideraron a los pacientes de 12 a 17 años (adolescentes) y 18 a 35 años (adultos jóvenes). Según criterios de inclusión/exclusión se conformó la población objeto, de la que se seleccionaron 82 pacientes mediante un muestreo al azar sistemático, a los cuales se les administro el Componente Estético del Índice de Necesidad de Tratamiento Ortodóncico y el cuestionario OHIP- estético de 14 preguntas. Los resultados obtenidos fueron de un total de 82 pacientes, el 59% correspondía al género femenino y el 41% al masculino, los adolescentes entre 12 y 17 años fueron un total de 15 pacientes y adultos jóvenes 67, considerados entre 18 y 35 años. Con respecto al cuestionario OHIP-14 se obtuvo una media 25,88 con una mínima de 3 y una máxima de 49. En relación al componente estético se obtuvo un 93% correspondiente a la categoría que “no necesita tratamiento ortodoncico”. En conclusión, se obtuvo una autopercepción de la estética dental y la calidad de vida de regular a buena en los pacientes adolescentes y adultos jóvenes evaluados en la Facultad de Odontología de la UNNE.
Іmprovement of performance characteristics and increase of productivity in the production of rolled-welded steel pipes
Authors: Doshchechkina I. , Dulich D.
Published: December 2023

Thin-sheet cold-rolled 08kp steel  is widely used in the production of two-layer copper-plated rolled-soldered tubes by complex processes of cold deformation with metal extraction and subsequent soldering. Problem. For high-quality molding, steel must have high technological plasticity, which is ensured by recrystallization annealing of rolls of rolled steel in periodic garden hood furnaces. It is impossible to obtain a sheet with increased properties, to correct the lack of sheet blanks due to poor-quality deformation, to prevent the subsequent aging of steel over time by processing in hood furnaces. During the manufacture of tubes, annealing of blanks, forming and soldering are carried out in different workshops of the enterprise, which is definitely not economical. Goal. The aim of the work is to improve both the technological and service characteristics of 08kp steel, intended for the manufacture of rolled soldered tubes, and to ensure the possibility of combining all processes of their production in a single line. To achieve the goal, it is necessary to develop an optimal mode of high-speed weakening heat treatment of riveted rolled steel and to study the possibility of replacing soldering in a muffle furnace with high-speed induction soldering. Methodology. The cold-rolled strip was subjected to continuous annealing at 700 °C and subsequent aging at 400 °C for 2 minutes using contact heating (~100 °C/s) in an argon atmosphere. Inductive soldering rolled up copper tubes were made at 1150ºС and duration of heating up to 30 seconds. After soldering, the tube was cooled in a thermostat with argon to a temperature of 900 – 950ºС and subjected to tempering at 600 – 650ºС lasting up to 2 s to prevent deformation aging. Result. Two-stage high-speed heat treatment (recrystallization tempering and aging) guarantees 08kp steel a high level of properties for defect-free forming of small-diameter tubes. High-speed induction soldering allows you to combine all processes in one current line. Practical value. The unification of all tube manufacturing processes in one current line ensures the improvement of their quality, surface cleanliness, absence of aging, reduction of defects and increase of production productivity, reduction of transport costs of manual labor and the number of working personnel. Tubes manufactured using the developed technology passed 100% incoming inspection under production conditions.
Analysis of opportunities to increase the level of active car safety
Authors: Tovstokoryi Maksym , Hnatov Andrii
Published: December 2023

Problem. Increasing the active safety of automobiles remains an important issue in modern automotive engineering. This study will investigate opportunities to increase the effectiveness and scope of automotive active safety measures. Current active safety measures, while effective, are limited in their ability to address the dynamic and multifaceted nature of hazards on the road. Factors such as human error, changing road conditions, and the emergence of new traffic patterns still pose significant risks. These challenges require a comprehensive analysis of opportunities to increase the effectiveness of active car safety. To address these challenges, novel technologies must be explored, industry collaboration must be encouraged, and adaptable standards must be established to integrate and enhance active safety features in vehicles. Thus, itis essential to identify and capitalize on opportunities for progress in active vehicle safety to reduce traffic crashes and promote safer transportation systems Goal. The overarching goal is to significantly improve the effectiveness and breadth of active safety measures for vehicles. This includes: enhanced protection, proactive risk reduction, technology integration, behavioral adaptation, and regulatory strengthening. Achieving these goals will require a multidisciplinary approach that combines technological innovation, behavioral science, regulatory adaptation, and industry collaboration to create a comprehensive and effective active vehicle safety ecosystem. Methodology. Analytical research methods are used, Researching and developing cutting-edge technologies. Originality. A detailed analysis was carried out and the principles of operation of systems and mechanisms included in active safety systems were presented. This analysis will allow to determine the advantages and disadvantages that should be paid attention to when studying these systems. Practical value. Enhanced active car safety offers a variety of benefits and has substantial value. Reduced accidents and fatalities: Reduced accidents and fatalities, advanced safety measures can significantly reduce the frequency and severity of accidents, leading to fewer injuries and fatalities on the road. Improved traffic flow, proactive safety systems reduce potential hazards and contribute to smoother traffic flow and less congestion caused by accidents. Technological innovation, advances in active safety can contribute to broader technological innovation and influence advances in areas other than automotive safety.
Non-alcoholic fatty liver disease and type 2 diabetes mellitus: diagnostic and therapeutic aspects. Review
Authors: Bentsa T. M.
Published: December 2023

The increase in the prevalence of non‑alcoholic fatty liver disease (NAFLD) occurs in parallel with the global epidemic of obesity and type 2 diabetes mellitus (T2DM) in the world. T2DM is an independent risk factor for the development of NAFLD. At the same time, researchers found that patients diagnosed with NAFLD have a two‑fold increased risk of developing T2DM. NAFLD is encompasses a spectrum of liver manifestations ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis and cirrhosis, which may ultimately progress to hepatocellular carcinoma. NASH is an aggressive form of NAFLD, associated with an increased risk of liver and non‑liver‑related mortality. Liver‑biopsy remains the gold standard for diagnosis, but the majority of patients liver damage can be diagnosed accurately by noninvasive methods.
The presence of NAFLD in a patient with T2DM makes it difficult to achieve adequate glycemic control, deepens the manifestations of insulin resistance and atherogenic dyslipidemia, increases the risk of serious cardiovascular events and chronic kidney disease. Lifestyle modification and treatment of concomitant T2DM should be undertaken in all patients with NAFLD. To reduce the severity of liver steatosis, weight reduction by 3—5% is necessary, to reduce the inflammatory‑necrotic process, a more significant reduction may be required — up to 10% within 6—12 months. Physical activity increases the sensitivity of insulin receptors, and in combination with diet leads to a significantly significant improvement in biochemical and histological indicators in patients with NAFLD. Early identification and management of patients with intensive dietary and lifestyle modification are essential to prevent the development of advanced liver disease and its complications. Pharmacological therapy should be administered to patients with NASH purposed on the fibrosis inhibition, especially in case of the established predictors of high risk of disease progression (age >50 years, metabolic syndrome, T2DM, or increase in the activity of alanine aminotransferase), as well as to the patients with active NASH with high inflammatory activity.
At the congress of the European Association for the Study of the Liver (EASL), which took place in Vienna on June 21—24, 2023, a new classification and nomenclature of NAFLD was adopted. It was proposed to replace the term «non‑alcoholic fatty liver disease» to the term «metabolic dysfunction‑associated steatotic liver disease» (MASLD). This diagnosis is established in patients with confirmed steatosis of the liver and one of five cardiometabolic risk factors: obesity, T2DM, insulin resistance, hyperlipidemia, atherosclerosis. The concept of «non‑alcoholic steatohepatitis» (NASH) has been changed to the concept of «metabolic dysfunction‑ associated steatohepatitis» (MASH). Coordination of the views of international and domestic experts in the field of studying this pathology will be important for clinical practice and scientific research.
Domestic researchers who have made important contributions to the study of digestive system diseases: images in art. Iryna Ivanivna Degtyareva
Authors: Gubergrits N. B.
Published: December 2023

In her article, the author does not provide biographical data of Professor Iryna Ivanovna Degtyareva, but shares thoughts, feelings, memories about the Teacher. Iryna Ivanivna Degtyareva was an outstanding person in every aspect. The author was amazed by her remarkable appearance when she first met her in 1976. She was a striking lady who captivated by her charm, talent, and, most importantly, professionalism. Then, Iryna Ivanivna was appointed as a reviewer of the candidate’s dissertation by N. B. Gubergrits before approbation. Iryna Ivanivna spent almost the whole day with N. B. Gubergrits, a young physician who had just graduated from a medical university, since it was her first time meeting her. The two of them sat until late at the department of faculty therapy of the Kyiv Medical Institute, where Iryna Ivanivna worked at the time. Her remarks were undoubtedly well‑grounded. However, Iryna Ivanivna did not only provide criticism; she offered instant guidance on how to fix errors and avoid “sharp edges”, all the while pointing out the advantages of the work. Then, like lately, everything was fair. Inflexibility accompanied this justice. Iryna Ivanivna’s first major lesson was to work hard and overcome barriers in the pursuit of truth and results. This extraordinary lady and scientist had a great intellect, tolerance for students’ mistakes, total loyalty to them, and unwavering determination to work with them. N. B. Gubergrits sought Professor Iryna Ivanivna Degtyareva’s consultation for her doctoral dissertation as a result. Iryna Ivanivna’s brilliant mind «burst out» with ideas that she genuinely shared with her students. The contribution of Iryna Ivanivna to the doctoral dissertation of N. B. Gubergrits and her title of professor are enormous. Much has been achieved with her help. Iryna Ivanivna took great pride in her students, including Ihor Mykolayovych Skrypnyk, Mykhaylo Yuriyovych Kolomoyets, and Natalya Vyacheslavivna Kharchenko. To her, they were more than just students. She looked after them in life as well as in science. Many clinicians use Iryna Ivanivna’s monographs as reference textbooks, including «Clinical Gastroenterology» and «Peptic Ulcer».
The problem of strategic human resource management in healthcare in Poland
Authors: Dubrovina N. , Kolesnikova O. , Siwiec A. , Dubrovina V. , Radchenko A.
Published: December 2023

Objective — to study the basic principles of the strategic human resource management in healthcare, to analyze the features of human resource management in healthcare organizations, to analyze the long‑term trends of the human resources in the healthcare in Poland and to propose the recommendations for the implementation of measures for strategic human resources management in healthcare organizations.
Results. The problems of the long‑term and short‑term tendencies of human resources in the healthcare in Poland are discussed in the article. The age, gender and regional distribution of the human resources in the healthcare are shown and the main factors influenced on the dynamics of these indicators are described. Taking into account different problems in the healthcare in Poland the importance of the strategic human resource management is presented and the general recommendations for health institutions are given.
Conclusions. Strategic management and analysis of human resources development are crucial in Polish healthcare. Health institutions need strategic plans and performance assessments for medical facilities. The expanded strategic management of medical organizations involves assessing both the external and internal environment, considering macroeconomic changes, regional shifts, market dynamics, mobility, qualifications, motivation of medical personnel, and evaluating the organization’s image among patients and public entities. In strategic human resources analysis, key factors include strategic intentions, forecasting challenges, positioning, and prioritizing human resources management. Given the complex macro environment of medical organizations, it’s crucial to identify the most significant factors, evaluate their potential impact, and formulate response measures within the organization’s strategy.
The difficulty of revascularization at myocardial infarction with ST-segment elevation during the military conflict: clinical scenarios. Review
Authors: Kopytsya M. P. , Petyunina O. V. , Vyshnevska I. R.
Published: December 2023

Russian military aggression against Ukraine challenged serious difficulties in the treatment of acute myocardial infarction with ST segment elevation (STEMI). Continuous stress, depression and insufficient pharmacotherapy resulted in the chronic coronary syndrome exacerbation, the increased number of STEMI cases and increased mortality because of the absence of timely myocardial reperfusion. The golden standard of the STEMI treatment is percutaneous coronary intervention (PCI), the result of which is the most effective reperfusion and patients’ survival. At the military conditions PCI possibility is restricted. The alternative to this method should be the fibrinolytic therapy, which has recently been rarely used as a reperfusion method in acute STEMI due to the availability of a network of catheter laboratories. The optimal variant of treatment at the condition of complicated logistical circumstances during the military time must be pharmacoinvasive strategy based on fibrinolysis and further PCI. Since the capabilities of reperfusion centers differ in the regions of Ukraine depending on the distance from the war zone, treatment strategies may be different. The main task in the STEMI treatment always must be the earliest renovation of myocardial circulation in the ischemic myocardium.
The authors highlighted scenarios of STEMI treatment at the condition of military conflict where pharmacoinvasive strategy might have advantages in case of difficulties with providing quick access to percutaneous coronary intervention.
When choosing a treatment strategy for acute STEMI, it is important to consider the specific conditions, the resources of the medical system, and the availability of medical care. The use of pharmacoinvasive strategy may be useful if the initial PCI is delayed beyond the recommended time, allowing for early reperfusion and improving treatment outcomes.
Physiological impact of heat stress and their alleviation measures in agriculture: A review
Authors: Jayara Alok Singh , Pant Chayan , Singh Sampurna Nand , Shukla Pavan , Singh Shubham , Pandey Sharad
Published: December 2023

Abiotic stresses are becoming more prevalent in modern agriculture as a result of shifting climate scenarios. Elevated temperature stress is one of the most important abiotic stresses to address since it has detrimental consequences for plant physiology, molecular structure, and phenology. The morphological impact occurs in the form of reduced germination, poor emergence, poor seedling vigor, abnormal seedling. Heat stress also results in the closure of stomata, reduced leaf size and consequent increase in stomatal density. One of the major physiological impacts of heat stress is on the fluidity of the membrane structure of the plant cell. Heat stress leads to increased fluidity of the thylakoid membrane and disruption of metabolic functions, which either deliver or accept electrons from PSII and, thus, cause dislodging of PSII from thylakoid membrane. The respiration generally increases in the temperature range of 0-35/ 40⁰C, reaches plateau at 40-50⁰C and decreases beyond 50⁰C due to damage to the respiratory mechanism. Elevated temperature directly impacts the cellular water content and indirectly through the increased water depletion rate from the soil. In order to design the appropriate corrective actions, it is crucial to research all the factors leading to heat stress thoroughly. The traditional agronomic and breeding interventions are crucial, but the rising food demand and the intensifying heat stress call for some cutting-edge biotechnological interventions, such as transgenics, genome editing, and CRISPR/cas9, to induce genome-level heat tolerance. The present review deals in detail with each of the previously listed aspects.
A Biopesticides and their impact on brinjal Jassid (Amrasca biguttula biguttula Ishida)
Authors: L.S. Bhushan , Raut A. M. , Talekar Nilesh , Chaudhary Bishal , Sonawane Vishal , A Ashwini
Published: December 2023

Brinjal (Solanum melongena) is a precious and nourishing vegetable grown worldwide in tropical and subtropical climates. Jassid (Amrasca biguttula biguttulaI.) (Hemiptera: Cicadellidae),of which nymphs and adults suck the cell sap from the underside of the brinjal leaves resulting in curling and affecting the photosynthesis process. The present study aimed to study the effectiveness of biopesticides and their impact on jassid and its natural enemy in different seasons. The field experiment arranged in randomized block design includes six biorational insecticides such has (T1)-Spinosad 45 % SC @ 0.4ml/l, (T2)-Neem Seed Kernel Extract(NSKE) 1% @ 2ml/l, (T3)-Beauveria bassiana 1x 108 @ conidia/ml @ 10ml/l, (T4)-Metarhizium anisopliae1x 108 conidia/ml @ 10ml/l, (T5)-Verticillium lecanii 1x108 conidia/ml @ 10ml/land (T6)-Untreated plots replicated in four times. It is resulted that all the biorational pesticides performed significantly better than the control. However, among the treatments, application of (T3)-Beauveria bassiana 1x108 conidia/ml @ 10 ml/l and (T2)-Neem Seed Kernel Extract (NSKE) 1% @ 2 ml/l  was found to have significantly better results against jassid,during Rabi(2021) and Kharif season (2022) respectively. For predatory coccinellids,(T2) - Neem Seed Kernel Extract (NSKE) 1% @ 2 ml/l and(T1)-Spinosad 45 % SC @ 0.4ml/l were found to be better compared to other treatments in Rabi and Kharif season. This research will help to understand the importance of biopesticides with eco-friendly approaches to manage jassid.
Evaluation of Boerhavia diffusa and Eichhornia crassipes plant extracts in vitro as potential antifungal agents against human pathogenic fungi Candida albician and Candida tropicalis : A comparative study
Authors: Kumar Mukesh , Singh Bikram Jit , Mukherjee Tapan Kumar , Sharma Pooja , Singh Raj
Published: December 2023

Plant extracts are used to make herbal remedies with no side effects and little expense. During the COVID-19 pandemic, fungal species responsible for mucormycosis were found resistant to a variety of antifungals, including flucytosine, ketoconazole, fluconazole, voriconazole, itraconazole and echinocandins, due to their variable susceptibility. Amphotericin B is widely used as an antifungal agent due to its high inhibition capacity against various fungi. The present study aimed to compare the antifungal potential of Amphotericin B and herbal extract in vitro. The experiment was designed to measure zones of inhibition with the help of well-diffusion method. Four solvents, viz. methanol, chloroform, hexane and distilled water, were used to extract plant extract. The efficiency of plant extracts was found to be low compared to Amphotericin B (1.4mm). Chloroform extract of Boerhavia diffusa was found antifungal against Candida albician and C. tropicalis (0.45mm). Methanol and hexane extract of Eichhornia crassipes showed higher antifungal activity (1.35mm) and (1.75mm), respectively. The plant extracts also showed significant antifungal activity against C. tropicalis, revealing its potential to be used as a natural antifungal agent (1.1mm). Additionally, the findings showed that the chloroform and methanol extracts of B. diffusa and E. crassipes were also efficient against C. albician and C. tropicalis. The findings provide important insights about using plant extracts as a potential alternative to conventional antifungal agents.
Efficient Deep Learning model for de-husked Areca nut classification
Authors: Patil Sameer , Naik Aparajita , Parab Jivan
Published: December 2023

Areca nut is a widely used agricultural product in India and even over the globe. Areca nut, a fruit of   areca palm (Areca catechu) is grown widely in the Asia-Pacific region.. Areca nut segregation is of prime importance in the areca nut industry. The quality segregation of peeled/de-husked nuts requires skilled workers. This process of manual segregation is time-consuming and can lead to erroneous classification. Recent deep learning (DL) advances have improved the performance in multi-class problems. The present  work presents the classification of de-husked areca nut among five classes using an efficient deep learning customized Convolutional Neural Network (CNN) and the results of this model were compared with the standard AlexNet architecture. The new CNN model was customized to obtain classification accuracy higher than the existing ones. A dataset of 300 nuts (60 per class) was created using a specially designed instrumentation setup. The areca nut images were then pre-processed and fed to these models to learn the features of the areca nut from different classes. The confusion matrix and Area Under the Curve - Receiver Operating Characteristics (AUC- ROC) were employed to assess the results of these models and cross-validated with 5 and 10-fold. The experimental results show that the CNN outperformed the AlexNet model with an average accuracy of 97.33% and 98.34%, F1 score of 97.48%, and 98.45% for 5 and 10 folds, respectively.
Treatment of textile effluent by using Burflower tree (Neolamarckia cadamba) leaf powder: Batch biosorption study
Authors: Talukdar Seema , Sarma Hari Prasad
Published: December 2023

The textile industry is one of the leading causes of major environmental problems worldwide. The textile dye effluents hold diverse kinds of dyes along with other contaminants. Various environmental legislations have been formulated and obligate the textile industries to treat the effluents prior to discharge into water bodies.  The present study aimed to evaluate the efficacy of removing two dyes, Congo red and Methylene blue, present in raw textile effluent by employing the powdered leaves of the Burflower (Neolamarckia cadamba) tree as adsorbent. The experiment was performed in a laboratory scale. The surface characterization of the adsorbent was carried out using Brunauer-Emmett-Teller (BET) surface area analysis, CHN elemental analyzer, FTIR and SEM-EDX analyses. The effluent was characterised before and after the biosorption process to check the efficiency of the process on the various parameters of the effluent. The values of the examined parameters were found to be decreased after the adsorption process. The removal percentages of the two dyes (Congo red = 76.35% and Methylene blue = 85.8%) using the adsorbent were also estimated by batch experiment studies. The findings of this study infer that the adsorbent as mentioned above, can be used to treat dye effluents.
Developing Organization using HRM Practices on Employee's Performance: An Empirical Analysis among Private Bank Employees in Tiruchirappalli
Authors: S. Divya  , K.R. Chandrakala
Published: December 2023

For retaining the human resources within the organizations, the firms have to encompass their employee force, since the workforce is considered to be the important source for attaining the competitive gain. The aim of the study is to identify the factors related with employee performance that are affected by the practices of HRM through varied dimensions. Further, the study has attempted to propose a model regarding the practices of HR that can be utilized to test and improve the employee performance. Data was collected from the employees working in private banks of Tiruchirappalli. The sample size of the study is 131. Questionnaire is the tool used for collecting responses from the employees. Analysis of the collected responses have been done through SPSS. Respondents have been selected through simple random sampling and analysis has been done through regression. The results of analysis reveal that there exists a strong relationship of HRM practices with the employee performance, with reference to the employees of private banks in Tiruchirappalli.
Reseña bibliográfica de: Raffa, C. (2020). Construir Mendoza. Obras y políticas públicas en el territorio: 1932 - 1943. Mendoza: Comité Editorial del Instituto de Historia del Arte - Facultad de Filosofía y Letras, 370 pp.
Authors: Campora Maria Clara
Published: December 2023

Es la reseña de un libro reciente
Roma redux: la romanización y las identidades romanas en el siglo XXI
Authors: Machuca Prieto Francisco
Published: December 2023

En el presente trabajo se presta atención a tres de las tendencias historiográficas que, centradas con preferencia en “lo identitario”, han adquirido durante los últimos veinte años un considerable peso en el estudio del mundo romano, propiciando importantes cambios a la hora de concebir las pertenencias colectivas. Desde los empeños por “decolonizar” la ciencia histórica al creciente auge de las interpretaciones globales, pasando por la incorporación de la perspectiva de género y la teoría feminista, las maneras de entender la llamada “romanización” y las identidades romanas se caracterizan hoy no solo por la adhesión general a una óptica alejada de los viejos esencialismos, sino también por focalizarse en nuevos temas, tales como el factor étnico, el papel de las comunidades locales, la conectividad y movilidad, el multiculturalismo, las hibridaciones o los grupos tradicionalmente invisibilizados. No obstante, este panorama novedoso ha hecho emerger nuevas problemáticas, como las reesencializaciones y la sobrerrepresentación de aspectos como la diversidad, el contacto, las resistencias o la mezcla cultural.
Epigrafía expuesta y romanización temprana en la Hispania republicana
Authors: Herrera Rando Javier
Published: December 2023

El objeto de este trabajo es reflexionar acerca del carácter de la romanización temprana característica del periodo republicano, usando como hilo argumental el desarrollo de la epigrafía expuesta en la península ibérica durante los siglos II y I a.E. Partiendo de la situación prerromana, se analizarán tres cambios que acontecen en las culturas epigráficas locales de ese periodo: la aparición de la epigrafía en bronce y su relación con la comunicación oficial, el desarrollo de conjuntos epigráficos urbanos y la progresiva latinización lingüística. Se señalarán los modelos romanos y las selecciones y adaptaciones locales, tomando en consideración tanto las inscripciones realizadas en latín como en lenguas y escrituras vernáculas.
Identification of Biomarker IL2Rβ in Ankylosing Spondylitis via Multi-Chip Integration Analysis of Gene Differential Expression
Authors: Xiao Bin , Cui Peng-Lei , Li Hong-Chao , Wang Chao , Zhang Yan-Zhuo , Wu Zhi-Min , Wu Cheng-Ai
Published: December 2023

Background: Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease that affects axial joints such as the spine. Early diagnosis is essential to improve treatment outcomes. The purpose of this study is to uncover underlying genetic diagnostic features of AS. Methods: We downloaded gene expression data from the Gene Expression Omnibus (GEO) database for three studies of groups of healthy and AS samples. After preprocessing and normalizing the data, we employed linear models to identify significant differentially expressed genes (DEGs) and further integrated the differential genes to acquire reliable differential transcriptional markers. Gene functional enrichment analysis was conducted to obtain enriched pathways and regulatory gene interactions were extracted from pathways to further elucidate pathway networks. Seventy-three reliably differentially expressed genes (DEGs) were integrated by differential analysis. Utilizing the regulatory relationships of the 21 Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway genes that were enriched in the analysis, a regulatory network of 622 genes was constructed and its topological properties were further analyzed. Results: Functional enrichment analysis found 73 DEGs that were strongly associated with immune pathways like Th17, Th1 and Th2 cell differentiation. Using KEGG combined with DEGs, six hub genes (KLRD1, HLA-DRB3, HLA-DRB5, IL2Rβ, CD247, and CXCL10) were suggested from the network. Of these, the IL2Rβ gene was significantly differentially expressed compared with the normal control. Conclusion: IL2Rβ (Interleukin-2 receptor beta) is strongly associated with the onset and progression of autoimmune joint diseases, and may be used as a potential biomarker of AS. This study offers new characteristics that can help in the diagnosis and individualized therapy of AS.
MENELISIK MODUS TINDAK PIDANA PENJUALAN ROKOK TANPA PITA CUKAI ATAU DILEKATI PITA CUKAI PALSU
Authors: Wulandari Destiny
Published: December 2023

Penelitian ini bertujuan untuk mengungkap modus tindak pidana penjualan rokok tanpa pita cukai atau yang dilekati pita cukai palsu, upaya yang dilakukan petugas Bea dan Cukai (BC) dalam menangani tindak pidana tersebut, dan menyajikan rekomendasi upaya penanganan tindak pidana serupa ke depannya. Penelitian ini merupakan penelitian kualitatif yang menggunakan pendekatan studi kasus dengan menganalisis seluruh putusan pengadilan negeri yang memuat pokok sengketa tindak pidana penjualan rokok tanpa pita cukai atau yang dilekati pita cukai palsu yang diputus tahun 2022. Hasil penelitian menunjukkan bahwa terdapat dua jenis modus tindak pidana yang dilakukan, yaitu modus sebagai pedagang perantara yang menjual rokok tanpa pita cukai milik pihak lain dan modus sebagai produsen rokok yang menjual rokok yang dilekati dengan pita cukai palsu yang dibeli dari pihak lain. Dalam menindak tindak pidana tersebut, petugas BC melakukan fungsi intelijen, fungsi penyidikan, dan fungsi penindakan. Untuk penanganan tindak pidana serupa ke depannya, petugas BC dapat mengedukasi masyarakat mengenai ketentuan tindak pidana tersebut dan melakukan intensifikasi pengawasan terhadap tindak pidana tersebut.
Examining the Awareness Levels, Usage Trends, and Influencing Factors of Emergency Contraceptives Among Women in Ussa Local Government Area of Taraba State, Nigeria: A Cross-Sectional Research Inquiry
Authors: Adaki Andeskebtso Yohanna , Anthony Jellason Yinalabi , Esvandiari Megia
Published: December 2023

Unintended pregnancies and unsafe abortions remain significant global public health concerns, particularly in low-income countries. This research assessed the awareness, usage, and influencing factors of emergency contraceptives among women in the Ussa Local Government Area of Taraba State, Nigeria. The study employed a cross-sectional survey research design where 384 questionnaires were distributed among sampled women of the reproductive age group (15-49 Years) in the study area. The findings indicate that while roughly half of the respondents were aware of emergency contraceptives, there is room for improvement in terms of disseminating information about their availability and usage. Regarding the usage of emergency contraception, a sizable portion of respondents (34.3%) said they had used it, although the majority (65.7%) had not.
Furthermore, formal sensitization on emergency contraceptives is lacking for a large part of the population, just as a significant proportion of respondents have yet to use them. The study also found that factors influencing women's attitudes toward emergency contraceptives in Ussa Local Government Area include economic constraints, knowledge gaps, moral beliefs, partner dynamics, social stigma, and the fear of negative health implications. Based on the findings of the study, the recommendations include enhancing health promotions by Health agencies in Ussa Local Government, encouraging parent-child discussions on reproductive health, engaging traditional and religious leaders in family planning promotions, establishing young girls-friendly centers, and implementing comprehensive reproductive health education programs to empower women and reduce unintended pregnancies.
STUDI POLA PENGGUNAAN OBAT ANTIINFLAMASI NON STEROID PADA PASIEN RHEUMATOID ARTHRITIS DI POLI PENYAKIT DALAM RSUD Dr. H. SLAMET MARTODIRDJO PAMEKASAN TAHUN 2022
Authors: Priyanka P.D. Anisya , Hasanah Naili Uswatun , Alrosyidi Achmad Faruk
Published: December 2023

Rheuamtoid Arthritis (rematik) adalah penyakit inflamasi sistemik kronik pada sendi-sendi tubuh yang mempunyai gejala klinik berupa gangguan nyeri pada persendian yang disertai rasa kaku, merah dan pembengkakan dan berlangsung kronis. Penelitian ini bertujuan untuk mengetahui pola penggunaan OAINS pada pasien rheumatoid arthritis di poli penyakit dalam RSUD Dr. H. Slamet Martodirdjo Pamekasan. Penelitian ini merupakan penelitian non eksperimental dengan rancangan analisis yang digunakan yaitu metode deskriptif. Data yang diperoleh dari penelusuran secara retrospektif. Penelitian dilakukan dengan melihat data rekam medis pasien terdiagnosis rheumatoid arthritis dengan jumlah sampel sebanyak 93 pasien dengan metode purposive sampling. Data hasil penelitian menunjukkan bahwa pasien yang banyak menderita rheumatoid arthritis adalah perempuan dengan jumlah 64 pasien (68,8%), usia yang terdiagnosis rheumatoid arthritis paling tinggi adalah usia 41-60 tahun dengan jumlah 55 pasien (59,2%), lamanya pasien yang terdiagnosis rheumatoid arthritis paling banyak adalah yang baru dengan jumlah 67 pasien (72,0%), skala nyeri pada rheumatoid arthritis paling banyak pada skala 3 sebanyak 45 pasien (48,4%), jenis OAINS yang paling sering digunakan yaitu meloksikam sebanyak 53 pasien (57,0%).
Sebuah Studi Pengembangan Bentuk Sediaan Obat : Olsalazine Sebagai Colonic Drug Targeting
Authors: Taufikurrahman Taufikurrahman
Published: December 2023

Penyakit inflamasi usus (IBD) merupakan kondisi yang mempengaruhi sistem pencernaan dan dapat menyebabkan gejala seperti diare, sakit perut, dan penurunan berat badan. IBD terdiri dari dua jenis yaitu colitis ulserativa dan penyakit Crohn. Kedua jenis IBD disebabkan oleh respon sistem kekebalan tubuh yang tidak tepat terhadap bakteri usus normal dan kemudian menyebabkan peradangan pada usus. Pengobatan IBD tergantung pada tingkat keparahan dan jenis penyakit.

Olsalazine, suatu prodrug salisilat, telah digunakan secara luas untuk mengobati colitis ulseratif dan ditemukan memiliki efek samping yang lebih sedikit dibandingkan dengan sulfasalazine, obat yang serupa. olsalazine diserap dengan cepat dalam usus halus dan kemudian diubah menjadi dua molekul asam salisilat. Namun, hanya sebagian kecil dari asam salisilat ini yang mencapai usus besar, di mana colitis ulseratif paling sering terjadi.

Salah satu pendekatan yang diusulkan adalah dengan menggunakan olsalazine sebagai colonic drug targeting. Pada pendekatan ini, olsalazine dimodifikasi dengan pengikat yang spesifik untuk sel epitel usus besar, sehingga obat tersebut dapat diantarkan langsung ke daerah yang terkena penyakit. Dari absorpsi dan ekskresi 5-ASA terjadi sangat cepat dan intensif sehingga didapatkan total 5-ASA yang tinggi di urin. Penggunaan 5-ASA (tanpa modifikasi senyawa atau formula) sebagai terapi IBD tidak akan efektif karena jumlah obat yang akan sampai ke kolon akan kecil.  Sedangkan penggunaan Olsalazine dengan diformulasi menjadi tablet konvensional efektif sebagai terapi IBD karena olsalazine sangat sedikit diabsorpsi di lambung dan usus halus.  Kajian selanjutnya tentang olsalazine sebagai colonic drug targeting dapat membuka pintu bagi pengembangan obat yang lebih efektif dan efisien dalam pengobatan IBD.
Work engagement as a central driver: Reassessing employee well-being metrics and performance
Authors: Rosalina Luh Ratna , Rahmawati Putu Indah , Sinarwati Ni Kadek
Published: December 2023

Traditional metrics of employee well-being, such as satisfaction and commitment, are now under scrutiny by scholars. There's growing concern that these measures might lead to complacency rather than maximizing workforce potential. Amidst this debate, work engagement is highlighted as a crucial determinant in enhancing workforce performance, especially in ever-evolving work contexts. This study aims to bridge existing gaps by unearthing the intricate relationships between work engagement, job satisfaction, and performance in the public sector. Data for the study were gathered through a survey questionnaire administered to 538 civil servants employed in the Indonesian government sector. Thus, the proposed mediation model was evaluated using Sobel test. The results revealed that work engagement does affect employee performance both directly and indirectly through job satisfaction. Intriguingly, the direct effect of work engagement on performance proved more dominant, marking it as a central contributor to productivity and efficacy in the public realm. This elucidates a complex interplay, emphasizing that while satisfaction plays a role, it's the intrinsic engagement of employees that stands paramount in driving optimal outcomes in the public sector.
Audit fees and related party transactions: Evidence from Indonesia
Authors: Ervianti Tantri Avita , Supatmi
Published: December 2023

This study empirically examines the impact of related party transactions on audit fees, focusing on distinguishing between tunneling-type and propping-type related party transactions. We investigate this causal relationship by analyzing the influence of various related party transactions on audit fees at the account level, allowing us to pinpoint the specific transactions that exert a more substantial influence on audit costs. Our research sample comprises 127 Indonesian manufacturing firms listed on the Indonesian Stock Exchange during the years 2020-2021, resulting in a dataset of 254 observations. Audit fees are quantified using the natural logarithm of the disclosed annual audit fees. We assess tunneling-type related party transactions by examining the proportion of assets and expenses involved in these transactions, breaking them down into categories such as account receivables, other receivables, and other assets. Similarly, propping-type related party transactions are evaluated based on the proportion of liability-based and sales-based transactions, further disaggregated into account payables, other payables, and other liabilities. Our hypothesis testing relies on a Panel Data Regression analysis model. Our findings reveal that tunneling and propping-type related party transactions significantly increase audit fees. Notably, we demonstrate that tunneling-related party transactions exert a more substantial impact on audit fees than propping-related party transactions, highlighting the significance of agency theory in understanding the risks associated with related party transactions.
Рівень контамінації об’єктів довкілля за хоріоптозу великої рогатої худоби
Authors: Коваленко С. О.
Published: December 2023

Акариформні кліщі, які є постійними ектопаразитами тварин, відносяться до високоспеціалізованих паразитів, що розповсюджуються здебільшого контамінативним шляхом. Можливість зараження тварин більшою мірою відбувається прямим контактним шляхом, а також шляхом передачі збудників через об’єкти тваринницьких приміщень, де утримуються інвазовані тварини. Істотне місце в оцінці активності епідемічного процесу при паразитарних хворобах належить результатам санітарно-паразитологічних досліджень, оскільки вони сприяють визначенню стану одного з ключових елементів – механізму передачі збудника. Метою досліджень було встановити рівень контамінації різних об’єктів довкілля кліщами виду Chorioptes bovis залежно від способу утримання великої рогатої худоби. Найвищі показники контамінації хоріоптесами встановлено за умови безприв’язного способу утримання тварин, де екстенсивний та інтенсивний індекси контамінації становили: підстилки з місць знаходження тварин – 100 % та 257,50 екз./кг, зіскобів із предметів, об які чухаються тварини, – 100 % та 194,38 екз./кг, підстилки з центру приміщення – 90 % та 80,56 екз./кг. Нижчі значення забрудненості кліщами спостерігали при дослідженні підстилки, відібраної з кутів приміщення, де екстенсивний та інтенсивний індекси контамінації становили 50 % та 43,75 екз/кг. За умови прив’язного способу утримання великої рогатої худоби екстенсивний індекс контамінації виявився нижчим, ніж у разі безприв’язного, і коливався у межах від 15 до 45 %, а інтенсивний індекс контамінації – від 41,67 до 90,28 екз/кг, де максимальний рівень забрудненості акариформними кліщами зафіксовано у зразках, відібраних з підстилки та зіскобах з предметів, розташованих в області голови тварин. Водночас у підстилці, відібраній з кутів приміщення, хоріоптесів не виявлено. Отримані дані дають змогу розширити вже наявну інформацію щодо механізму передачі акариформних кліщів Chorioptes bovis серед сприйнятливих тварин та дозволять підвищити ефективність планування профілактичних заходів за наявності хоріоптозу у великої рогатої худоби.
Does Interest Really Matter? Interest in Nature as a Possible Determinant of Pro-Environmental Behaviour
Authors: Neurohr Anna-Lena , Möller Andrea , Bergmann-Gering Alexander , Johnson Bruce
Published: December 2023

Understanding the drivers of pro-environmental behaviour (PEB) is essential, as environmental degradation stemming from human actions is a profound challenge for humanity. Research suggests that in addition to connection to nature and environmental attitudes, interest in nature, especially when aroused in youth, can be a significant motivational factor driving people’s engagement in PEB. However, the relationship between interest in nature and other determinants of PEB, as well as their collective influence on PEB on adolescents, is still greatly understudied. We aim to bridge this gap by incorporating interest in nature into a model explaining PEB. We used data from a cross-sectional study with German lower secondary school students (n = 1092, age 10-15 years), applying four self- report scales: 1) interest in nature (SIN), 2) connection to nature (DCN), 3) environmental attitudes (2-MEV), and 4) general ecological behaviour (GEB). Our findings demonstrate that interest in nature not only positively correlates with other determinants of PEB but also significantly influences PEB itself. This suggests that cultivating interest in nature among adolescents can potentially lay the groundwork for their development of PEB. Therefore, interest in nature should be considered in future research studies both exploring PEB and evaluating the effectiveness of ESD programs.
Basic Organizational Design
Authors: Lestari Imelia
Published: December 2023

Basic Organizational Design
Naturalistic use of psychedelics does not modulate processing of self-related stimuli (but it might modulate attentional mechanisms): an event-related potentials study comparing non-users and experienced users of classic psychedelics
Authors: Orlowski Paweł , Hobot Justyna , Ruban Anastasia , Szczypiński Jan , Bola Michał
Published: December 2023

Classic psychedelics are able to profoundly alter the state of consciousness and lead to acute experiences of ego dissolution – the blurring of the distinction between representations of self and the external world. However, whether repeated use of psychedelics is associated with more prolonged and permanent modifications to the concept of self remains to be investigated. Therefore, we conducted a preregistered, cross-sectional study in which experienced psychedelics users (15 or more lifetime experiences with psychedelics; N = 56) were compared to non-users (N = 57) in terms of neural reactivity to a Self-name (i.e., each participant’s own name) stimulus, which is known to robustly activate a representation of self. Two control stimuli were additionally used: an Other-name stimulus, as a passive control condition in which no reaction was required; and a Target-name stimulus, to which participants provided a manual response and which thus constituted an active control condition. Analysis of the amplitude of the P300 ERP component evoked by the Self-name revealed no difference between the psychedelics users and non-users. However, in comparison to non-users, psychedelics users exhibited a smaller increase in P300 amplitude when processing the task-relevant Target-name (in relation to both Self- and Other-names). Therefore, our data suggests that regular naturalistic use of psychedelics may not be related to long-term changes in the representation of self, but it might potentially affect allocation of attentional resources to task-relevant stimuli.
Mental Health Among Students
Authors: Akbar Muhammad Ikhsan
Published: December 2023

Kesehatan mental selalu menjadi topik yang menarik untuk dibahas. Kesehatan mental tak kalah pentingnya dengan Kesehatan fisik. Keduanya sama - sama harus diperhatikan dan dijaga dengan baik. Ada pepatah yang mengatakan, “di dalam tubuh yang sehat, terdapat jiwa yang sehat”. Apabila kesehatan mental seorang individu terganggu, ia akan mengalami kesulitan untuk fokus, suasana hati yang buruk, dan sulit mengendalikan emosi yang dapat mengarah pada perilaku buruk. Kesehatan mental diartikan sebagai terpenuhinya fungsi nental yang mampu membuat individu produktif, mampu memiliki hubungan yang sehat dengan orang lain dan mampu mengatasi kesulitan. Metode dalam pengabdian ini adalah ceramah dan diskusi. Informan atau subjek dalam pengabdian ini adalah remaja kajian ngaji asik masjid Nurul Huda Karangasem Surakarta. Hasil dari pengabdian ini adalah memberikan sosialisasi terkait penringnya menjaga Kesehatan mental dan manajemen agar Kesehatan mental tetap terjaga.