bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediction of Decay Modes for Superheavy Nuclei with Magic Number of Neutrons and Protons
Authors: Bai G. M. C. V. , Revathi R.
Published: February 2024

The Cubic plus Yukawa plus Exponential (CYE) model has been used to study the different decay properties of Superheavy nuclei 298,310114, 306,318122, 308,310124, 310,322126 and compared them with the available theoretical and experimental values. Here, the half-lives of several clusters have been computed that have not yet been detected experimentally. Hopefully, this will assist future research in this area. As a result of comparing the three different decay modes (α-decay, cluster radioactivity and spontaneous fission), it was possible to predict the predominant decay modes of Superheavy nuclei.
An Inflated Modelling of Zero Truncated Poisson Ailamujia Distribution and Its Application to Child Mortality and Genetics Count Data
Authors: Agarwal A. , Pandey H.
Published: February 2024

In this paper, an attempt has been made to develop a model as Inflated form of zero truncated Poisson Ailamujia distribution. The proposed model involved two parameters, estimated by the maximum likelihood estimation method and derived as an expression of the Fisher Information Matrix. To evaluate the adequacy and applicability of the proposed model, it is applied to real data sets on child mortality and genetic count data.
Study of A Ferroelectric Liquid Crystal Mesogen by Geometrical Optimization and Electro-Optic Characterization
Authors: Goswami D.
Published: February 2024

In the present work one biphenyl benzoate cored liquid crystal was characterized using geometrical optimization and electro-optic study. Geometry of the molecule was optimized using Hartree-Fock method with 3-21G basis. The simulated value of molecular length and dipole moment was reported. The Infrared (IR) spectra were also simulated and analyzed. The energy gap between highest occupied molecular orbit (HOMO) and lowest unoccupied molecular orbit (LUMO) was calculated. The phase transition temperatures and phase sequences were identified by observing the topological defects in the optical textures at different temperatures under polarizing microscope. It exhibited ferroelectric smectics C* (SmC*) phase for a wide range of temperature and then directly melted into isotropic phase. The optical tilt angle of the compound was measured in SmC* phase and was fitted with mean field model to explore the nature of phase transition. The applicability of the compound for display applications were judged based on the parameters measured.
A Spatio-Temporal Groundwater Fluoride Contamination Assessment to Infer the Hydro-geochemical Analysis of Punjab Satluj Floodplain
Authors: Harsimrat K.
Published: February 2024

Punjab Satluj Floodplain is a Hydro-geologically, ecologically, and economically very precious resource-rich landscape. This area is fragile due to flood risk; since its inception, it has attracted lots of economic and sociocultural activities that adversely affect hydro-geochemical conditions. Spatial and statistical analysis of land use and land cover change reveals that from 1975 to 2011, this landscape experienced 56.55 % land use and land cover transformation. Maximum transformation is noticed in the agricultural and built-up areas. In 1975, agricultural and built-up areas covered 47057.11 hectares (45.13 %) and 469.5 hectares (0.45 %), respectively, of the Punjab Satluj floodplain, which was expanded and covered 91011.36 hectares (87.28 %) and 6495.7 hectares (6.24 %) respectively in 2011. Adversities of these values can be estimated from the groundwater contamination analysis that reveals the specific electrical conductance (EC), nitrate (NO3), potassium (K), calcium (Ca), magnesium (Mg), sodium (Na), and fluoride (F) contamination in the water exceed its permissible consumption limits and effects ecological health. The present research work is the epigram of the hydrogeochemical condition of the Punjab Satluj floodplain concerning the spatial distribution of fluoride contamination and its proximate causes.
Design of Home Automation System with Emergency Control
Authors: Mishra R. V. , Gupta T. , Batra V. , Kaur I.
Published: February 2024

In today's society, there is a growing demand for smart home solutions that not only enhance convenience but also make a significant impact on affordability and widespread adoption. This paper describes the proposed design of a Node MCU-based Home Automation system with an integrated Wi-Fi module that enables internet-based remote control of home devices. The design utilizes a basic code template to connect with the Tasmota Web interface to configure the ESP module. The system is integrated with Alexa, offering various integration options such as routines, schedules and alarms. Furthermore, it adds a manual control feature for situations where there is no internet connection and an additional level of safety through emergency controls in the event of electronic failure. A comparison   of energy usage with and without the use of the proposed system is also reported. A noticeable decrease in daily electricity consumption is observed on using the designed automation system. To ensure cost-effectiveness, locally available components are utilized in the design. Consequently, it ensures that enhanced comfort, convenience, and control over one's living environment are available to a wider audience.
Mathematical Analysis of Fractional Diabetes Model via an Efficient Computational Technique
Authors: Batchu V. M. , Gill V. , Rana S. , Singh Y.
Published: February 2024

Diabetes is referred to a chronic metabolic disease signalized by elevated levels of blood glucose (also known as blood sugar level), which results over time in serious damage to the heart, blood vessels, eyes, kidneys, and nerves in the body. A mathematical assessment of the diabetes model using the Caputo fractional order derivative operator is given in this research paper. The concept of a Caputo fractional order derivative is a novel class of non-integer order derivative that has many applications in real-life scenarios. The proposed model is represented by a set of fractional ordinary differential equations. The authors employed the Sumudu Transform Homotopy Perturbation Method (STHPM) for finding the series solutions of the model being studied. By giving various numerical values to the respective model parameters, graphical analysis is also performed.  It is observed in the numerical discussion that a decrease in both fractional order  and  leads to decrease in the number of diabetic people.
Investigation of Site Dependent Donor-Acceptor (Al-N) Doping Effect into ZnO for Optoelectronic Applications
Authors: Sayed M. A. , Kamruzzaman M. , Liton M. N. H. , Helal M. A. , Rahman M.
Published: February 2024

In this study, the density functional theory (DFT) is used to investigate the effect of the incorporation of Al (donor) in the Zn-site and N (acceptor) in the O-site of ZnO. The detailed theoretical study highlights the confirmation of p-type conductivity and bandgap (0.58 and 0.21 eV) narrowing exhibits in N- and (Al-N)-doped ZnO systems. p-type nature is explicitly observed by introducing acceptor bands at the top of the valance band (VB). Whereas, degenerate n-type conductivity is seen in Al-doped ZnO and a widened bandgap of 2.70 eV is attributed to Burstein-Moss (BM) effect. The calculated value of the effective mass of the (Al-N)-doped ZnO system is lower than that of the un-doped ZnO. Enhancement of the absorption and photoconductivity in the visible region for N- and (Al-N)-doped ZnO could be due to the availability of more density of states. Importantly, reflectivity, refractive index, transmittance, dielectric constants, and optical band gap have also been calculated. Higher transmittance of the samples suggested that these could be suitable for the window material of solar cells. The optical bandgap value supports the electronic bandgap value. Therefore, our finding would be helpful to design high-performance homo-junction based electronic and optoelectronic devices.
Antibacterial Evolution of ZnO Nanoparticles Synthesized via Wet-Chemical Method
Authors: Satheesh A. , Adinarayana D. , Ramanjaneyulu M. V. V. , Usha H. , Amitkumar  , Jogayya K. N.
Published: February 2024

In present days the essentiality of antibiotics is a big challenge for public health because of the spreading of infections severely. Nano metal oxides show effective antibacterial activity and are non-toxic compared to organic anti-microbes because of their high surface area to volume ratio. Nano ZnO is one of the most emerging nano metal oxides that has been used in various applications such as fire retard, anti-microbe, anti-wrinkle, etc. Nano zinc oxide was synthesized by the wet chemical process using zinc nitrate hexahydrate as a precursor. The synthesized nano ZnO powder was subjected to characterization to know the morphology and physical properties. FTIR analysis was employed for the identification of functional group, X-ray diffraction is to identify the crystalline structure, SEM-EDX analysis is employed to determine the morphological structure and size of the synthesized nanoparticles and elemental confirmation, and TEM is used to determine the particle size and shape of synthesized nanoparticles. The synthesized nano ZnO is screened for its antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis by disc diffusion method.
Modeling and Simulation of Semiactive and Active Suspension System using Quarter Car Model
Authors: V. Barethiye
Published: February 2024

A passive suspension system is used by the automotive industry to control the motion of the vehicle. Nowadays, semiactive and active suspension systems are a requirement of commercial vehicles to improve performance characteristics and road comfort. The objective of the paper is to present a comprehensive analysis of passive, semiactive, and active suspension systems. The fuzzy logic controller is used to present the active suspension system. The characteristic of the shock absorber (damper) is non-linear and hysteresis in nature. Hence, a Magneto-rheological (MR) damper-based Bouc-Wen model is utilized to present the semiactive suspension. The comparative analysis of vehicle suspension characteristics has been carried out by using a bump road profile. The modeling of the Bouc-Wen model and quarter car system is carried out in the Simulink environment. The simulated results show that the semiactive and active suspension systems can be a better option for vehicle suspension systems to provide passengers with road comfort.
Nano Fuzzy Z - Open Sets and its Application in Nano Fuzzy Topological Space
Authors: Rajwade P. , Navalakhe R.
Published: February 2024

This research aims to define and investigate the properties of Nano fuzzy Z-open explicitly sets defined in Nano fuzzy topological spaces. Also, there is an attempt to define Nano fuzzy Z-closure Nano fuzzy Z-interior in Nano fuzzy topological spaces. The work has grown by incorporating Nano fuzzy δ open sets, Nano fuzzy δ semi-open sets, Nano fuzzy δ semi-open sets, and Nano fuzzy δ pre-open sets. Also, the work has been concluded with a numerical application of the Nano fuzzy score function in the medical field (to check the proper diagnosis of disease and drug combinations given to the patient).
DAB method transfer for potency of cannabinoids in dry cannabis flower
Authors: Cvetkovikj Karanfilova Ivana , Stoilkovska Gjorgievska Veronika , Stefkov Gjoshe , Karapandzova Marija , Trajkovska Ana , Davkova Iskra , Acevska Jelena , Kulevanova Svetlana , Brezovska Katerina
Published: February 2024

Cannabis is considered as heterogeneous matrix that contains complex profile of secondary metabolites, where more than 100 are classified as phytocannabinoids, present with an uneven distribution. In order to ensure its quality, application of suitable sample preparation techniques as well as time- and cost-efficient analytical methods is required. The DAB method depicts the obligatory procedure for potency testing of cannabinoids in cannabis flower in the EU. In this study we have performed method transfer in order to confirm the applicability of the method in determination of varying quantities of cannabioniods in different cannabis strains, focusing on samples with low content of CBD or THC or samples where one of these two cannabiniods is not detected. The HPLC-DAD method was validated and used for routine control of the content and consistency of medical cannabis. Limits of detection, limits of quantitation, accuracy, precision, and intermediate precision were found to be highly satisfactory.

Keywords: HPLC assay, CBD, THC, CBN, CBDA, THCA, method validation, DAB, quality control
Overview of the compendial methods for quantitative determination of glucose in solutions for intravenous infusion
Authors: Imeri Shkendije , Zaharieva Snezana , Majnova Gordana , Angelova Suzana , Acevska Jelena , Brezovska Katerina , Karchev Vasil , Dimitrovska Aneta
Published: February 2024

This paper provides a review of the pharmacopoeial methods for determination of the content of glucose in parenteral solutions (HPLC/RID method, polarimetry and volumetric titration) and evaluation of all critical aspects of the proposed methods, with a focus on accuracy, precision, time of analysis and resources for introducing, maintenance and conducting analysis. Comparative analysis of the results from assay (ten independent determinations) of Glucose 5% w/v solution for intravenous infusion, obtained using all three methods, was performed. The analysis confirmed that there is no statistical difference between the testing results obtained with each method, indicating that all three methods provide valid accurate and precise results. However, the availability of the equipment and trained personnel may be the crucial factor for small laboratories for selection of the method for assay of glucose in parenteral preparations.
The obtained results and discussion on all critical aspects (accuracy, precision, time of analysis and resources for introducing, maintenance and conducting analysis) of the proposed methods, provide a valuable input to small laboratories on the suitability of these methods for quality control of Glucose 5% w/v solution for intravenous infusion.

Keywords: Glucose, HPLC/RID, Polarimetry, Volumetry
Qiraâ€™ah Variations and Qur'anic Meanings: An Analysis of Imam Hamzah's Thought
Authors: Mahdi Afandi  , Abdullah Fahmi
Published: February 2024

The Quran has chosen Arabic as the exclusive language to convey the meanings it contains. Arabic is the language of the Quran. The Arabic used by the Quran encompasses more than one dialect and pronunciation. The Quran was revealed in seven modes, making it convenient for readers who are not exclusively Arabs. This study aims to reveal how the diversity of Qiraat influences the interpretation of the Quran, particularly the Qiraat of Imam Hamzah. This study utilizes a descriptive approach, which involves addressing a problem by presenting the material comprehensively. It is a library research type that gathers data from library literature. The results of this study indicate that Imam Hamzah's Qiraat has made substantial contributions to the interpretation of Quranic verses, particularly those related to legal provisions (ayat ahkam). There are many characteristics that distinguish Imam Hamzah's Qiraat from those of other imams, including differences in I'rob, root words, grammar, and pronunciation. There is also a unique Qiraat exclusive to Imam Hamzah, although it is rare. Additionally, some Qiraat differs from those of other imams but aligns consistently with the readings of Al-Kisai or Abu Bakr from Asim.
Compliance and Efficacy of Positive Airway Pressure Therapy in Rapid Eye Movement Sleep Related Obstructive Sleep Apnea Patients
Authors: Jin Myung Ho , Kim Min Woo , Choi Myoung Su
Published: February 2024

Background and Objectives The aim of this study was to investigate the compliance and treatment effects of both rapid eye movement sleep related obstructive sleep apnea (REM_ OSA) and non-stage specific OSA (NS_OSA) patients prescribed with positive airway pressure (PAP) therapy.Subjects and Method Medical records of 223 patients diagnosed with OSA from July 2021 to March 2023 were retrospectively analyzed. Six-month PAP compliance, symptoms questionnaires were compared for 60 patients in the REM_OSA group and 163 in the NS_OSA group.Results For patients in mild NS_OSA, mild REM_OSA, moderate NS_OSA, moderate REM_ OSA, severe NS_OSA, and severe REM_OSA groups, the compliance of six-month PAP was 50.0%, 33.3% (p=0.467), 69.6%, 58.3% (p>0.999), 70.7%, and 0% (p=0.023), respectively. In the NS_OSA group, PAP led to significant daytime sleepiness score improvement (7.3±3.4 to 5.7±3.6, p=0.022). In contrast, the scores for the REM_OSA group changed insignificantly (8.4±4.7 to 6.8±2.9, p=0.332).Conclusion This study revealed that PAP therapy compliance of the REM_OSA group was not lower than that of the NS_OSA group, except for the severe subgroup. However, REM_OSA was found to be less effective in improving daytime sleepiness symptoms than NS_OSA after PAP therapy.
Clinical Characteristics of Primary Thyroid Lymphoma
Authors: Yoo Byung Joon , Bahn Jun Sung , Song Chang Myeon , Ji Yong Bae , Tae Kyung
Published: February 2024

Background and Objectives Primary thyroid lymphoma is rare in thyroid cancer and also in extranodal lymphoma. As such, there has been only a few studies done on this rare disease, and this study evaluated its clinical characteristics and prognosis.Subjects and Method A retrospective review was conducted on 18 patients who were treated for primary thyroid lymphoma between January 2006 and December 2021. We investigated clinical, radiologic, pathologic findings, treatment modalities and prognosis.Results The study involved 18 patients, all of whom were confirmed through histopathological assessments via thyroidectomy (5/18), core needle biopsy (12/18), and incisional biopsy (1/18). Among these, three patients were male, while 15 were female, with a mean age of 66.4±8.78 (49-82). The most common symptom was a palpable neck mass (8/18). The most common pathologic type was diffuse large B cell lymphoma (9 patients), followed by mucosaassociated lymphoid tissue lymphoma (6 patients). At the time of diagnosis, 3 (20.0%) 8 (53.3%), 0, and 4 (26.7%) number of patients were found in Stage I, II, III and IV, respectively. Twelve patients received chemotherapy and three patients received radiation therapy. Three patients were lost to follow-up without treatment.Conclusion Primary thyroid lymphoma should be included in differential diagnosis when making a diagnosis for rapid growing thyroid nodule. Core needle biopsy is considered as first line pathologic diagnostic tool due to limitation of fine needle cytology.
Association of Metabolic Health With Hearing Impairment Among Older Adults: A Nationwide Analysis of Follow-Up Data
Authors: Kim Hye Jun , Jeong Seogsong , Park Beom Sik , Oh Yun Hwan , Suh Michelle J.
Published: February 2024

Background and Objectives To investigate the association between metabolic syndrome (MetS) and hearing impairment (HI) in elderly Korean adults using a large-scale cohort data.Subjects and Method Data was collected on 729664 adults who underwent at least one health screening between 2009 and 2012 from the Korea National Health Insurance Service-Senior Cohort. The study utilized a Cox proportional hazards regression model to assess the relationship between MetS and the risk of developing HI. The results were presented as an adjusted hazard ratio (aHR) with 95% confidence intervals (CI). All subjects were monitored until the occurrence of HI, death, or December 31, 2019.Results A total of 10102 cases of HI were identified during the follow-up period of 4920397 person-years. In the crude model, MetS was linked to an increased risk of developing HI (HR, 1.14; 95% CI, 1.10-1.19). No significant association was found after adjusting for potential confounding factors (aHR, 1.03; 95% CI, 0.99-1.08). Abnormal triglyceride (TG) levels were associated with a higher risk of HI compared to normal TG levels (aHR, 1.07; 95% CI, 1.03-1.12). In addition, the risk of HI increased as TG levels increased (>150 mg/dL).Conclusion Abnormalities in TG levels were independently associated with an increased risk of HI among elderly adults. Management of TG levels may protect against the risk of incident HI.
AN UNCOMMON PRESENTATION OF SEPTUM PELLUCIDUM ANATOMICAL VARIATIONS: A CASE REPORT OF GENERALIZED TONIC-CLONIC SEIZURE IN A HEALTHY ADULT
Authors: Parça Nurullah , Ataş İsmail , Çelik Ali , Bilir Özlem
Published: February 2024

ABSTRACT:
Introduction: The septum pellucidum (SP) is a thin, transparent, dual-membrane structure located between the lateral ventricles of the brain. Incidentally identified through imaging modalities, this variation, while rare, may manifest with symptoms such as neuropsychiatric disorders, headache, dizziness, seizures, nausea, and vomiting. In this report, we present the case of a healthy middle-aged man with CV and CSP, who sought medical attention in the emergency department (ED) due to a generalized tonic-clonic seizure (GTCS).
Case Report: A 40-year-old male without any known medical history presented to our emergency department with a GTCS. Considering this as the first seizure, blood and imaging tests were conducted, all of which showed no abnormalities. Non-contrast computed tomography revealed sequel cystic encephalomalacic areas in the left occipital and right frontal cerebral hemispheres, consistent with a parapharyngeal epidermoid cyst, and the presence of cavum septum pellucidum et vergae. Emergency consultation from the neurological clinic was sought, and an electroencephalogram showed no seizure activity. He was subsequently discharged with a recommendation for follow-up at the neurology outpatient clinic.
Conclusion: This case prompts critical considerations in the emergency medicine realm regarding the potential relationship between anatomical variations in the septum pellucidum and emergent seizure activity.
Keywords: Septum pellucidum, seizure, cavum vargae, emergency
EFEKTIVITAS GAYA PEMASARAN BAKAR-BAKAR DUIT OLEH E-COMMERCE DI INDONESIA
Authors: Nurlaily Liafatra , Kuntari Oktarini
Published: February 2024

This study aims to determine the effectiveness of marketing strategies using the style of burning money by e-commerce to achieve the goals of increasing data, people’s purchasing power using e-commerce, and changing the behaviour of Indonesian people towards digitalization. The literature study method was used to conduct this research due to limited time and resources to conduct case studies or collect data through interviews with e-commerce visitors. The results of the study show the effectiveness of the money-burning marketing style in increasing the number of e-commerce users, increasing the amount of annual e-commerce revenue, and increasing the percentage of activity in the use of e-commerce by internet users in Indonesia.
Pengaruh Sistem Informasi Akuntansi dan Pemahaman Akuntansi Pemerintahan terhadap Kualitas Laporan Keuangan Puskesmas di Kabupaten Demak
Authors: Saripuspita Syafi'ah Candra , Sari Cahyani Tunggal , Budiyono Rokhmad
Published: February 2024

This study aims to determine the effect of Accounting Information Systems and Understanding of Government Accounting on the Quality of Financial Statements. The sampling technique in this study was using Proportional Stratified Random Sampling. The research method used is a descriptive analysis method, a statistical analysis method consisting of multiple linear regression analysis, partial significant testing (t-test) and testing the coefficient of determination (R²). The results of this study indicate that the accounting information system has no significant effect on the quality of financial reports, while the understanding of government accounting has a significant effect on the quality of the financial reports of the Community Health Centers in Demak Regency.
PENERAPAN STRATEGI 7P MARKETING MIX PADA GROSIR KOSMETIK
Authors: Juniadi Muhammad Nur , Lashwaty Nina Dewi , Mursid Mursid
Published: February 2024

Penggunaan kosmetik yang meluas termasuk di Indonesia membuat banyak pihak mendirikan perusahaan manufaktur dan perusahaan dagang produk terkait. Hal ini membuat persaingan semakin ketat. Marketer diharuskan untuk mengadopsi strategi pemasaran untuk memenangkan hati konsumen. Salah satu strategi pemasaran yang banyak diadopsi oleh toko kosmetik termasuk Ivone Grosir Kosmetik adalah 7P marketing mix. Teknik Sampling Insidental diaplikasikan dalam penelitian ini. Teknik pengumpulan data yang digunakan adalah angket, observasi dan wawancara. Nilai Cronbach’s Alpha 0.887 menyatakan reliabilitas angket tinggi. Data yang diperoleh merupakan data primer. Variabel bebas terdiri dari produk, harga, promosi, tempat, SDM, proses dan bukti fisik. Keputusan pembelian merupakan variabel terikat. Dari Uji Analisis Linier Berganda satu tahap diperoleh hasil bahwa variabel harga, bukti fisik, proses dan promosi memiliki pengaruh positif terhadap keputusan pembelian, sedangkan yang lain berpengaruh negatif. Dari Uji F diketahui bahwa semua variabel bebas dalam penelitian ini memiliki pengaruh secara simultan terhadap variabel terikat. Berdasalkan hasil Uji t ditemukan pengaruh secara parsial dari variabel-variabel harga, bukti fisik dan proses terhadap variabel keputusan pembelian, sementara variabel yang lain tidak memiliki pengaruh parsial. Menurut Analisis Koefisien Determinasi diperoleh fakta bahwa variabel-variabel bebas yang dimasukkan ke dalam penelitian ini berpengaruh 57.2% terhadap variabel terikat.
RELIGIUSITAS, PELAYANAN TERBAIK, DAN PROMOSI SEBAGAI FAKTOR KEPUTUSAN NASABAH UNTUK SAVING MONEY DI PERBANKAN SYARIAH
Authors: Alfian Ahmad Hijri , Dian Essa Nugrahini Dian Essa Nugrahini Dian Essa Nugrahini
Published: February 2024

Tujuan Penelitian ini adalah untuk mengetahui religiusitas, pelayanan terbaik, dan promosi sebagai faktor yang memperkuat keputusan nasabah untuk melakukan saving money pada industri perbankan syariah di Jawa Tengah, yang dampaknya juga akan semakin memperkuat industri keuangan syariah di Indonesia. Penelitian berbentuk kuantitatif dan sampel akan diukur menggunakan data primer yang berasal dari kuesioner kepada populasi penelitian yaitu nasabah Industri Bank Syariah yang ada di Jawa Tengah. Hasil penelitian menunjukkan religiusitas, pelayanan dan promosi berpengaruh positif terhadap keputusan nasabah dalam menabung di bank syariah
DETERMINAN KINERJA KARYAWAN PT. SMARTFREN TELECOM TBK
Authors: Kusuma Endah Fatqur , Indriastuti Ariyani
Published: February 2024

Abstract.

Performance is the result of work in terms of quality and quantity achieved by an employee in carrying out their duties and responsibilities. The purpose of this research is to analyze the influence of compensation, leadership and career path on performance employee .Free variable in this research, namely compensation, leadership and career path, as well as the dependent variable, namely performance. Research population is an employee of PT. Smartfren Telecom Tbk Semarang Branch Office, with amount sample of 38 respondents. The data collection method is by distributing questionnaires to respondents. Data analysis uses multiple linear regression. Based on instrument test results data obtained results valid and reliable. Study this too has done it fulfil classical assumption test criteria. The result show that compensation, leadership and career path have a significant positive effect on employee performance.
HOW TO INFLUENCER AND VIRAL MARKETING INCREASE PURCHASE INTENTION
Authors: Sulistio Elbert , Dewi Liliana
Published: February 2024

Heaven Scent is a business engaged in the perfumery industry and was established in 2021. Various marketing efforts made by Heaven Scent are promotions using influencer marketing and viral marketing. This study was conducted to determine the effect of influencer marketing and viral marketing on purchase intention in products from Heaven Scent. This type of research uses quantitative method research methods with the population, namely followers of Instagram @heavenscentindonesia. Data collection was carried out by questionnaire by Google Form distributed to Heaven Scent social media followers. Sampling using purposive sampling with a sample size of 100 respondents. The data analysis method used in this research is Statistical Product and Service Solution (SPSS) with multiple linear regression analysis method. The results show that the variables of influencer marketing (X1) and viral marketing (X2) have a significant effect on purchase intention, The conclusion that can be drawn from this study is that influencer marketing and influencer marketing variables affect the purchase intention of Heaven Scent products.
Comorbidity patterns in cardiovascular diseases: the role of life-stage and socioeconomic status
Authors: Cruz-Ávila Héctor A. , Ramírez-Alatriste Fernando , Martínez-García Mireya , Hernández-Lemus Enrique
Published: February 2024

Cardiovascular diseases stand as a prominent global cause of mortality, their intricate origins often entwined with comorbidities and multimorbid conditions. Acknowledging the pivotal roles of age, sex, and social determinants of health in shaping the onset and progression of these diseases, our study delves into the nuanced interplay between life-stage, socioeconomic status, and comorbidity patterns within cardiovascular diseases. Leveraging data from a cross-sectional survey encompassing Mexican adults, we unearth a robust association between these variables and the prevalence of comorbidities linked to cardiovascular conditions. To foster a comprehensive understanding of multimorbidity patterns across diverse life-stages, we scrutinize an extensive dataset comprising 47,377 cases diagnosed with cardiovascular ailments at Mexico’s national reference hospital. Extracting sociodemographic details, primary diagnoses prompting hospitalization, and additional conditions identified through ICD-10 codes, we unveil subtle yet significant associations and discuss pertinent specific cases. Our results underscore a noteworthy trend: younger patients of lower socioeconomic status exhibit a heightened likelihood of cardiovascular comorbidities compared to their older counterparts with a higher socioeconomic status. By empowering clinicians to discern non-evident comorbidities, our study aims to refine therapeutic designs. These findings offer profound insights into the intricate interplay among life-stage, socioeconomic status, and comorbidity patterns within cardiovascular diseases. Armed with data-supported approaches that account for these factors, clinical practices stand to be enhanced, and public health policies informed, ultimately advancing the prevention and management of cardiovascular disease in Mexico.
Polygenic risk score predicts all-cause death in East Asian patients with prior coronary artery disease
Authors: Qin Min , Wu Yonglin , Fang Xianhong , Pan Cuiping , Zhong Shilong
Published: February 2024

Introduction

Coronary artery disease (CAD) is a highly heritable and multifactorial disease. Numerous genome-wide association studies (GWAS) facilitated the construction of polygenic risk scores (PRS) for predicting future incidence of CAD, however, exclusively in European populations. Furthermore, identifying CAD patients with elevated risks of all-cause death presents a critical challenge in secondary prevention, which will contribute largely to reducing the burden for public healthcare.

Methods

We recruited a cohort of 1,776 Chinese CAD patients and performed medical follow-up for up to 11 years. A pruning and thresholding method was used to calculate PRS of CAD and its 14 risk factors. Their correlations with all-cause death were computed via Cox regression.

Results and discussion

We found that the PRS for CAD and its seven risk factors, namely myocardial infarction, ischemic stroke, angina, heart failure, low-density lipoprotein cholesterol, total cholesterol and C-reaction protein, were significantly associated with death (P ≤ 0.05), whereas the PRS of body mass index displayed moderate association (P < 0.1). Elastic-net Cox regression with 5-fold cross-validation was used to integrate these nine PRS models into a meta score, metaPRS, which performed well in stratifying patients at different risks for death (P < 0.0001). Combining metaPRS with clinical risk factors further increased the discerning power and a 4% increase in sensitivity. The metaPRS generated from the genetic susceptibility to CAD and its risk factors can well stratify CAD patients by their risks of death. Integrating metaPRS and clinical risk factors may contribute to identifying patients at higher risk of poor prognosis.
Differential effects of fish-oil and cocoa-butter based high-fat/high-sucrose diets on endocrine pancreas morphology and function in mice
Authors: Albeloushi Shaima , Hasan Amal , Arefanian Hossein , Sindhu Sardar , Al-Rashed Fatema , Kochumon Shihab , Abukhalaf Nermeen , Jacob Texy , Shenouda Steve , Al Madhoun Ashraf , Al-Mulla Fahd , Ahmad Rasheed
Published: February 2024

Introduction

A high-fat/high-sucrose diet leads to adverse metabolic changes that affect insulin sensitivity, function, and secretion. The source of fat in the diet might inhibit or increase this adverse effect. Fish oil and cocoa butter are a significant part of our diets. Yet comparisons of these commonly used fat sources with high sucrose on pancreas morphology and function are not made. This study investigated the comparative effects of a fish oil-based high-fat/high-sucrose diet (Fish-HFDS) versus a cocoa butter-based high-fat/high-sucrose diet (Cocoa-HFDS) on endocrine pancreas morphology and function in mice.

Methods

C57BL/6 male mice (n=12) were randomly assigned to dietary intervention either Fish-HFDS (n=6) or Cocoa-HFDS (n=6) for 22 weeks. Intraperitoneal glucose and insulin tolerance tests (IP-GTT and IP-ITT) were performed after 20-21 weeks of dietary intervention. Plasma concentrations of c-peptide, insulin, glucagon, GLP-1, and leptin were measured by Milliplex kit. Pancreatic tissues were collected for immunohistochemistry to measure islet number and composition. Tissues were multi-labelled with antibodies against insulin and glucagon, also including expression on Pdx1-positive cells.

Results and discussion

Fish-HFDS-fed mice showed significantly reduced food intake and body weight gain compared to Cocoa-HFDS-fed mice. Fish-HFDS group had lower fasting blood glucose concentration and area under the curve (AUC) for both GTT and ITT. Plasma c-peptide, insulin, glucagon, and GLP-1 concentrations were increased in the Fish-HFDS group. Interestingly, mice fed the Fish-HFDS diet displayed higher plasma leptin concentration. Histochemical analysis revealed a significant increase in endocrine pancreas β-cells and islet numbers in mice fed Fish-HFDS compared to the Cocoa-HFDS group. Taken together, these findings suggest that in a high-fat/high-sucrose dietary setting, the source of the fat, especially fish oil, can ameliorate the effect of sucrose on glucose homeostasis and endocrine pancreas morphology and function.
Nonlinear association of the systemic immune-inflammatory index with mortality in diabetic patients
Authors: Meng Chunli , Liu Kai
Published: February 2024

Background

It has been demonstrated that in diabetic patients, an elevated neutrophil-lymphocyte ratio (NLR) is independently connected with higher cardiovascular and all-cause mortality. It is unclear, however, if the systemic immune-inflammatory index (SII) and the mortality rate among diabetic patients are related. Investigating the linkage between SII and diabetes patients’ risk of cardiovascular and all-cause death was the aim of the study.

Methods

4972 diabetics who were chosen from six rounds of the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2016 were the study’s participants. The optimal SII threshold with the highest correlation with survival outcomes was identified by applying the Maximum Selection Ranking Statistical Method (MSRSM). To assess the relationship between SII and cardiovascular and all-cause mortality in diabetics, subgroup analysis and Cox regression modeling were employed. Furthermore, smoothed curve fitting was utilized to determine the nonlinear relationship of them.

Results

Over the course of a median follow-up of 69 months (interquartile range [IQR], 54-123 months), 1,172 (23.6%) of the 4,972 diabetic patients passed away. These deaths included 332 (6.7%) cardiovascular deaths and 840 (16.9%) non-cardiovascular deaths. Individuals were categorized into higher (>983.5714) and lower (≤983.5714) SII groups according to MSRSM. In multi-variable adjusted models, subjects with higher SII had a significantly increased chance of dying from cardiovascular disease (HR 2.05; 95% confidence interval (CI):1.42,2.97) and from all causes (HR 1.60; 95% CI:1.22,1.99). Kplan-Meier curves showed similar results. Subgroup studies based on age, sex, BMI, drinking, smoking, and hypertension revealed that the connection maintained intact. The previously stated variables and SII did not significantly interact (p interaction > 0.05). In diabetic patients, smooth curve fitting revealed a nonlinear correlation between SII and mortality.

Conclusion

In diabetic patients, elevated SII is linked to higher cardiovascular and all-cause mortality.
Prediction of treatment response in lupus nephritis using density of tubulointerstitial macrophage infiltration
Authors: Wang Jingjing , Lou Wenyuan , Zhu Mengyue , Tu Yuanmao , Chen Duqun , Qiu Dandan , Xu Feng , Liang Dandan , Cheng Zhen , Zhang Haitao
Published: February 2024

Background

Lupus nephritis (LN) is a common disease with diverse clinical and pathological manifestations. A major challenge in the management of LN is the inability to predict its treatment response at an early stage. The objective of this study was to determine whether the density of tubulointerstitial macrophage infiltration can be used to predict treatment response in LN and whether its addition to clinicopathological data at the time of biopsy would improve risk prediction.

Methods

In this retrospective cohort study, 430 patients with LN in our hospital from January 2010 to December 2017 were included. We used immunohistochemistry to show macrophage and lymphocyte infiltration in their biopsy specimens, followed by quantification of the infiltration density. The outcome was the treatment response, defined as complete or partial remission at 12 months of immunosuppression.

Results

The infiltration of CD68+ macrophages in the interstitium increased in patients with LN. High levels of CD68+ macrophage infiltration in the interstitium were associated with a low probability of treatment response in the adjusted analysis, and verse vice. The density of CD68+ macrophage infiltration in the interstitium alone predicted the response to immunosuppression (area under the curve [AUC], 0.70; 95% CI, 0.63 to 0.76). The addition of CD68+cells/interstitial field to the pathological and clinical data at biopsy in the prediction model resulted in an increased AUC of 0.78 (95% CI, 0.73 to 0.84).

Conclusion

The density of tubulointerstitial macrophage infiltration is an independent predictor for treatment response in LN. Adding tubulointerstitial macrophage infiltration density to clinicopathological data at the time of biopsy significantly improves risk prediction of treatment response in LN patients.
Association between systemic immune inflammation index, systemic inflammation response index and adult psoriasis: evidence from NHANES
Authors: Ma Rui , Cui Lian , Cai Jiangluyi , Yang Nan , Wang Yuanyuan , Chen Qianyu , Chen Wenjuan , Peng Chen , Qin Hui , Ding Yangfeng , Wang Xin , Yu Qian , Shi Yuling
Published: February 2024

Background

The systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) are both novel biomarkers and predictors of inflammation. Psoriasis is a skin disease characterized by chronic inflammation. This study aimed to investigate the potential association between SII, SIRI, and adult psoriasis.

Methods

Data of adults aged 20 to 80 years from the National Health and Nutrition Examination Survey (NHANES) (2003–2006, 2009–2014) were utilized. The K-means method was used to group SII and SIRI into low, medium, and high-level clusters. Additionally, SII or SIRI levels were categorized into three groups: low (1st-3rd quintiles), medium (4th quintile), and high (5th quintile). The association between SII-SIRI pattern, SII or SIRI individually, and psoriasis was assessed using multivariate logistic regression models. The results were presented as odds ratios (ORs) and confidence intervals (CIs). Restricted cubic spline (RCS) regression, subgroup, and interaction analyses were also conducted to explore the potential non-linear and independent relationships between natural log-transformed SII (lnSII) levels or SIRI levels and psoriasis, respectively.

Results

Of the 18208 adults included in the study, 511 (2.81%) were diagnosed with psoriasis. Compared to the low-level group of the SII-SIRI pattern, participants in the medium-level group had a significantly higher risk for psoriasis (OR = 1.40, 95% CI: 1.09, 1.81, p-trend = 0.0031). In the analysis of SII or SIRI individually, both SII and SIRI were found to be positively associated with the risk of psoriasis (high vs. low group OR = 1.52, 95% CI: 1.18, 1.95, p-trend = 0.0014; OR = 1.48, 95% CI: 1.12, 1.95, p-trend = 0.007, respectively). Non-linear relationships were observed between lnSII/SIRI and psoriasis (both p-values for overall < 0.05, p-values for nonlinearity < 0.05). The association between SII levels and psoriasis was stronger in females, obese individuals, people with type 2 diabetes, and those without hypercholesterolemia.

Conclusion

We observed positive associations between SII-SIRI pattern, SII, SIRI, and psoriasis among U.S. adults. Further well-designed studies are needed to gain a better understanding of these findings.
Protein S-palmitoylation modification: implications in tumor and tumor immune microenvironment
Authors: Chen Yijiao , Li Yongsheng , Wu Lei
Published: February 2024

Protein S-palmitoylation is a reversible post-translational lipid modification that involves the addition of a 16-carbon palmitoyl group to a protein cysteine residue via a thioester linkage. This modification plays a crucial role in the regulation protein localization, accumulation, secretion, stability, and function. Dysregulation of protein S-palmitoylation can disrupt cellular pathways and contribute to the development of various diseases, particularly cancers. Aberrant S-palmitoylation has been extensively studied and proven to be involved in tumor initiation and growth, metastasis, and apoptosis. In addition, emerging evidence suggests that protein S-palmitoylation may also have a potential role in immune modulation. Therefore, a comprehensive understanding of the regulatory mechanisms of S-palmitoylation in tumor cells and the tumor immune microenvironment is essential to improve our understanding of this process. In this review, we summarize the recent progress of S-palmitoylation in tumors and the tumor immune microenvironment, focusing on the S-palmitoylation modification of various proteins. Furthermore, we propose new ideas for immunotherapeutic strategies through S-palmitoylation intervention.
T-cell virtuosity in ‘‘knowing thyself”
Authors: Acuto Oreste
Published: February 2024

Major Histocompatibility Complex (MHC) I and II and the αβ T-cell antigen receptor (TCRαβ) govern fundamental traits of adaptive immunity. They form a membrane-borne ligand-receptor system weighing host proteome integrity to detect contamination by nonself proteins. MHC-I and -II exhibit the “MHC-fold”, which is able to bind a large assortment of short peptides as proxies for self and nonself proteins. The ensuing varying surfaces are mandatory ligands for Ig-like TCRαβ highly mutable binding sites. Conserved molecular signatures guide TCRαβ ligand binding sites to focus on the MHC-fold (MHC-restriction) while leaving many opportunities for its most hypervariable determinants to contact the peptide. This riveting molecular strategy affords many options for binding energy compatible with specific recognition and signalling aimed to eradicated microbial pathogens and cancer cells. While the molecular foundations of αβ T-cell adaptive immunity are largely understood, uncertainty persists on how peptide-MHC binding induces the TCRαβ signals that instruct cell-fate decisions. Solving this mystery is another milestone for understanding αβ T-cells’ self/nonself discrimination. Recent developments revealing the innermost links between TCRαβ structural dynamics and signalling modality should help dissipate this long-sought-after enigma.
SOCS1 expression in cancer cells: potential roles in promoting antitumor immunity
Authors: Ilangumaran Subburaj , Gui Yirui , Shukla Akhil , Ramanathan Sheela
Published: February 2024

Suppressor of cytokine signaling 1 (SOCS1) is a potent regulator immune cell responses and a proven tumor suppressor. Inhibition of SOCS1 in T cells can boost antitumor immunity, whereas its loss in tumor cells increases tumor aggressivity. Investigations into the tumor suppression mechanisms so far focused on tumor cell-intrinsic functions of SOCS1. However, it is possible that SOCS1 expression in tumor cells also regulate antitumor immune responses in a cell-extrinsic manner via direct and indirect mechanisms. Here, we discuss the evidence supporting the latter, and its implications for antitumor immunity.
Characterization and mechanism of simultaneous degradation of aflatoxin B1 and zearalenone by an edible fungus of Agrocybe cylindracea GC-Ac2
Authors: Guo Changying , Fan Lixia , Yang Qingqing , Ning Mingxiao , Zhang Bingchun , Ren Xianfeng
Published: February 2024

Contamination with multiple mycotoxins is a major issue for global food safety and trade. This study focused on the degradation of aflatoxin B1 (AFB1) and zearalenone (ZEN) by 8 types of edible fungi belonging to 6 species, inclulding Agaricus bisporus, Agrocybe cylindracea, Cyclocybe cylindracea, Cyclocybe aegerita, Hypsizygus marmoreus and Lentinula edodes. Among these fungi, Agrocybe cylindracea strain GC-Ac2 was shown to be the most efficient in the degradation of AFB1 and ZEN. Under optimal degradation conditions (pH 6.0 and 37.4°C for 37.9 h), the degradation rate of both AFB1 and ZEN reached over 96%. Through the analysis of functional detoxification components, it was found that the removal of AFB1 and ZEN was primarily degraded by the culture supernatant of the fungus. The culture supernatant exhibited a maximum manganese peroxidase (MnP) activity of 2.37 U/mL. Interestingly, Agrocybe cylindracea strain GC-Ac2 also showed the capability to degrade other mycotoxins in laboratory-scale mushroom substrates, including 15A-deoxynivalenol, fumonisin B1, B2, B3, T-2 toxin, ochratoxin A, and sterigmatocystin. The mechanism of degradation of these mycotoxins was speculated to be catalyzed by a complex enzyme system, which include MnP and other ligninolytic enzymes. It is worth noting that Agrocybe cylindracea can degrade multiple mycotoxins and produce MnP, which is a novel and significant discovery. These results suggest that this candidate strain and its enzyme system are expected to become valuable biomaterials for the simultaneous degradation of multiple mycotoxins.