bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Application of Exercise Stress Echocardiography in an Outpatient Pediatric Population
Authors: Cotrim Nuno , Café Hugo M. , Guardado Jorge , Cordeiro Pedro , Cotrim Hortense , Martins Rui , Baquero Luís , Cotrim Carlos
Published: April 2024

Background: Exercise stress echocardiography (ESE) is commonly employed in adults, but its applicability in pediatric populations remains to be clarified. Methods: A total of 309 consecutive children (C), with a mean age of 14.1 ± 2.6 years (range 6–17 years), underwent treadmill ESE starting in 2002. They were divided into two groups: Group I comprised 258 children, including 237 with symptoms related to exercise (such as chest pain, fatigue, lipothymia/syncope, or one aborted sudden death), 15 with electrocardiogram (ECG) abnormalities, and 6 with a positive ECG stress test showing ST changes. Group II consisted of 10 asymptomatic children whose parents requested routine screening, 11 with symptoms unrelated to exercise, 12 with a family history of sudden death, and 17 with known pathologies (including 10 with hypertrophic cardiomyopathy, 2 with aortic coarctation, and the remainder with various conditions, such as Cortriatriatum sinister, pulmonary stenosis, subaortic stenosis, bicuspid aortic valve, left ventricular hypertrophy related to arterial hypertension, and aortic switch operation). Regional wall motion abnormalities (RWMAs) and transvalvular or intraventricular (IVG) gradients were assessed using 2D and continuous-wave Doppler, respectively, in all cases. Results: The success rate was 100% (309/309). Stress-induced RWMAs were observed in two children. A significant IVG (>30 mmHg) was detected in 101 out of the 258 children (39%) in Group I, who presented with exercise-related symptoms, ECG abnormalities, or positive stress ECG. In Group I, the odds ratio (OR) of ESE reproducing the symptoms in children with IVG compared to those without IVG was 8.22 (95% CI: 4.84–13.99, p < 0.001). Conclusions: Treadmill ESE is both feasible and safe for pediatric populations. RWMAs demonstrated limited utility in our cohort of children, while IVG induced by exercise was frequently observed in symptomatic children.
Numerical Investigation on the Capability of Modeling Approaches for Composite Cylinders under Low-Velocity Impact Loading
Authors: Rezaei Akbarieh Shiva , Ma Dayou , Sbarufatti Claudio , Manes Andrea
Published: April 2024

Composite pressure vessels can be exposed to extreme loadings, for instance, impact loading, during manufacturing, maintenance, or their service lifetime. These kinds of loadings may provoke both visible and invisible levels of damage, e.g., fiber breakage matrix cracks and delamination and eventually may lead to catastrophic failures. Thus, the quantification and evaluation of such damages are of great importance. Considering the cost of relevant full-scale experiments, a numerical model can be a powerful tool for such a kind of study. This paper aims to provide a numerical study to investigate the capability of different modeling methods to predict delamination in composite vessels. In this study, various numerical modeling aspects, such as element types (solid and shell elements) and material parameters (such as interface properties), were considered to investigate delamination in a composite pressure vessel under low-velocity impact loading. Specifically, solid elements were used to model each layer of the composite pressure vessel, while, in another model, shell elements with composite layup were considered. Compared with the available experimental data from low-velocity impact tests described in the literature, the capability of these two models to predict both mechanical responses and failure phenomena is shown.
Visualized Experimental Study of Soil Temperature Distribution around Submarine Buried Offshore Pipeline Based on Transparent Soil
Authors: Li Hui , Meng Yajing , Sun Yilong , Guo Lin
Published: April 2024

The temperature distribution around the offshore burial pipeline is an important factor affecting its safety design and economic operation. The traditional test method cannot obtain the continuous temperature distribution of soil owing to the constraints of placing measurement sensors in soil. The transparent soil model test is an alternative method to realize the visualization research of soil temperature. In this paper, a relationship between the temperature of transparent soil and pixel intensity was first established. Then, the transparent soil test and numerical simulation, considering the natural convection, were carried out to study the temperature distribution around the submarine pipeline during start-up and stable operation. The influence of buried depth and pipeline diameter was analyzed. The results suggest that the continuous temperature distribution can be obtained visually by using a transparent soil test, and the observed heating zone of influence extended to a radial distance of 2.6 pipe diameters. The numerical analysis results show that the influence zone of the temperature of pipeline is a distance of four pipeline diameters at a temperature difference of 45 °C. The buried depth and pipeline diameter have little influence on the influence zone. In addition, the contour curves of soil temperature around the pipeline with different diameter are similar in shape. With the decrease in the buried depth of pipeline, the temperature gradient of soil around the pipeline decreases, which is caused by the natural convection.
Natural Sources of Therapeutic Agents Used in Skin Conditions
Authors: Dinu Monica , Tatu Alin Laurențiu , Cocoș Dorin Ioan , Nwabudike Lawrence Chukwudi , Chirilov Ana Maria , Stefan Claudia Simona , Earar Kamel , Dumitriu Buzia Olimpia
Published: April 2024

Skin conditions are numerous and often have a major impact on patients’ quality of life, and effective and safe treatment is very important. The conventional drugs used for skin diseases are usually corticosteroids and antimicrobial products that can induce various side effects, especially with long-term use, which is why researchers are studying alternatives, especially biologically active natural products. Three products caught our attention: bee venom (BV), due to reported experimental results showing anti-inflammatory, antibacterial, antiviral, antioxidant, antimycotic, and anticancer effects, Ficus carica (FC) due to its demonstrated antioxidant, antibacterial, and anti-inflammatory action, and finally Geranium essential oil (GEO), with proven antifungal, antibacterial, anti-inflammatory, and antioxidant effects. Following a review of the literature, we produced this paper, which presents a review of the potential therapeutic applications of the three products in combating various skin conditions and for skin care, because BV, FC, and GEO have common pharmacological actions (anti-inflammatory, antibacterial, and antioxidant). We also focused on studying the safety of the topical use of BV, FC, and GEO, and new approaches to this. This paper presents the use of these natural therapeutic agents to treat patients with conditions such as vitiligo, melasma, and melanoma, as well as their use in treating dermatological conditions in patients with diabetes.
A Novel Auction-Based Truck Appointment System for Marine Terminals
Authors: Parmaksizoglou Ilias Alexandros , Bombelli Alessandro , Sharpanskykh Alexei
Published: April 2024

Background: Increased maritime trade has led to a surge in drayage operations, causing congestion and environmental issues in port areas. Truck Appointment Systems (TASs) are commonly used to manage truck arrival rates, yet transparency and equity in slot allocation remain problematic, fostering distrust between Licensed Motor Carriers (LMCs) and Marine Terminal Operators (MTOs). Methods: This study proposes a polycentric approach to improve truck scheduling and ensure that those impacted by decisions are involved in the decision-making process. A single-round auction mechanism focused on optimizing the truck hauling process through a pricing policy that promotes sincere bidding is introduced. The proposed approach employs an optimization strategy to achieve equitable coordination in truck synchronization through means of adaptable capacity management. Results: Numerical experiments assessing scenarios of noncollaborative behavior against partial collaboration between MTOs and LMCs demonstrate the effectiveness of the proposed approach in enhancing user satisfaction and terminal conditions for a case study focused on a medium-sized terminal. Collaboration between trucking companies is shown to increase utility per monetary unit spent on slot acquisition. Conclusions: The polycentric strategy offers a solution to TAS limitations by ensuring stakeholder participation with respect to flexibility and transparency by ensuring that those impacted by decisions are involved in the decision-making process.
The Synthesis and Structure of Scandium Dichloride of Sterically Demanding Aminopyridinato Ligands
Authors: Qayyum Sadaf
Published: April 2024

The reaction of the potassium salt of (2,6-diisopropylphenyl)-[6-(2,4,6-triisopropylphenyl)-pyridine-2-yl]-amine (Ap*H) with the equimolar ratio of [ScCl3] in tetrahydrofuran (thf) resulted in the mononuclear mono(aminopyridinato) scandium dichloride complex [Ap*ScCl2(thf)2]. An X-ray analysis showed the title compound to be monomeric. The compound [C40H59Cl2N2O2Sc] crystallized in the monoclinic space group, P21/n, and possessed the following cell parameters: a  =  12.4441(8) b  =  22.9975(10) c  =  13.9971(8) Å, β  =  92.297(5)°, V  =  4002.5(4) A3, and Z  =  4. Hirshfeld analyses show that H…H (91.1%), H…C/C…H (5.0%), and H…Cl/Cl…H (3.9%) are the contributing interactions in the solid-state structure. The compound was further characterized by NMR spectroscopy, and its purity was confirmed by elemental analysis.
Zirconium-Modified Medium-Entropy Alloy (TiVNb)85Cr15 for Hydrogen Storage
Authors: Saksl Karel , Matvija Miloš , Fujda Martin , Ballóková Beáta , Varcholová Dagmara , Kubaško Jakub , Möllmer Jens , Lange Marcus , Podobová Mária
Published: April 2024

In this study, we investigate the effect of small amounts of zirconium alloying the medium-entropy alloy (TiVNb)85Cr15, a promising material for hydrogen storage. Alloys with 1, 4, and 7 at.% of Zr were prepared by arc melting and found to be multiphase, comprising at least three phases, indicating that Zr addition does not stabilize a single-phase solid solution. The dominant BCC phase (HEA1) is the primary hydrogen absorber, while the minor phases HEA2 and HEA3 play a crucial role in hydrogen absorption/desorption. Among the studied alloys, Zr4 (TiVNb)81Cr15Zr4 shows the highest hydrogen storage capacity, ease of activation, and reversibly retrievable hydrogen. This alloy can absorb hydrogen at room temperature without additional processing, with a reversible capacity of up to 0.74 wt.%, corresponding to hydrogen-to-metal ratio H/M = 0.46. The study emphasizes the significant role of minor elemental additions in alloy properties, stressing the importance of tailored compositions for hydrogen storage applications. It suggests a direction for further research in metal hydride alloys for effective and safe hydrogen storage.
Effect of Macro Fibers on the Permeability and Crack Surface Topography of Layered Fiber Reinforced Concrete
Authors: Zeng Wei , Wang Weiqi , Wang Qiannan , Li Mengya , Zhang Lining , Tong Yunyun
Published: April 2024

This paper describes the effects of macro fibers on permeability and crack surface topography of layered fiber-reinforced concrete (FRC) specimens with different layering ratios under uniaxial tensile load. The crack permeability of layered FRC specimens is investigated by a self-designed permeability setup. The topographical analysis of crack surfaces is investigated by a custom-designed laser scanning setup. The results show that when the fiber volume content and layering ratio of the FRC layer are constant, the tensile toughness of layered FRC specimens depends on the proportion of steel fiber in macro fibers, and with an increase in the proportion of steel fiber, the tensile toughness of layered FRC specimens increases. For the layered FRC specimens, the crack permeability is much lower than that of the normal concrete (NC) specimen. A significant positive synergistic effect on crack impermeability can be achieved by the combination of steel fiber and polypropylene fiber in the SF80PP2.3 specimen. The crack surface roughness parameter (Rn) values of the NC layer in layered FRC specimens are all higher than those of the NC specimen, and the crack surface Rn of the FRC layer in layered FRC specimens is higher than that of the unlayered FRC specimens. This can effectively increase the head loss of cracks and reduce the crack permeability of layered FRC specimens.
Nonlinear Static Bending and Forced Vibrations of Single-Layer MoS2 with Thermal Stress
Authors: Chen Xiaolin , Huang Kun , Zhang Yunbo
Published: April 2024

Single-layer molybdenum disulfide (MoS2) has been a research focus in recent years owing to its extensive potential applications. However, how to model the mechanical properties of MoS2 is an open question. In this study, we investigate the nonlinear static bending and forced vibrations of MoS2, subjected to boundary axial and thermal stresses using modified plate theory with independent in-plane and out-of-plane stiffnesses. First, two nonlinear ordinary differential equations are obtained using the Galerkin method to represent the nonlinear vibrations of the first two symmetrical modes. Second, we analyze nonlinear static bending by neglecting the inertial and damping terms of the two equations. Finally, we explore nonlinear forced vibrations using the method of multiple scales for the first- and third-order modes, and their 1:3 internal resonance. The main results are as follows: (1) The thermal stress and the axial compressive stress reduce the MoS2 stiffness significantly. (2) The bifurcation points of the load at the low-frequency primary resonance are much smaller than those at high frequency under single-mode vibrations. (3) Temperature has a more remarkable influence on the higher-order mode than the lower-order mode under the 1:3 internal resonance.
Analysis of Mechanical and Thermal Properties of Polymer Materials Derived from Recycled Overprinted Metallized PP Films
Authors: Stachowiak Tomasz , Postawa Przemysław , Chmielarz Marcin , Grzesiczak Dominik
Published: April 2024

Polymer materials and their composites are one of the most frequently used materials in the packaging and food industries. This applies to both disposable and reusable packaging, layered films with barrier properties, as well as densely overprinted polymer films and metallized food wrap films. According to statistical data from Plastics Europe, approximately 40% of processed thermoplastics are used to produce packaging, including single- and multi-layer film packaging. Growing requirements and new EU directives require the use of recycled materials in new products, which is not easy because the properties of recyclates may differ significantly from those of the primary materials with which the former are mixed. This work attempts to analyze the properties of the primary material used to produce a film using the casting method in comparison with the industrial recyclate obtained by the processing of film made of the primary material and then overprinted and metallized. The process of obtaining re-granulates and preparing test samples was presented, and the mechanical, structural, and thermal properties of the tested materials were compared. The conducted research and the obtained results demonstrated the advisability of conducting advanced mechanical recycling, which leads to obtaining re-granulates with repeatable processing properties and thermal and mechanical properties comparable to the original material despite the impurities they contain.
The Nonlinear Bending of Sector Nanoplate via Higher-Order Shear Deformation Theory and Nonlocal Strain Gradient Theory
Authors: Sadeghian Mostafa , Jamil Asif , Palevicius Arvydas , Janusas Giedrius , Naginevicius Vytenis
Published: April 2024

In this context, the nonlinear bending investigation of a sector nanoplate on the elastic foundation is carried out with the aid of the nonlocal strain gradient theory. The governing relations of the graphene plate are derived based on the higher-order shear deformation theory (HSDT) and considering von Karman nonlinear strains. Contrary to the first shear deformation theory (FSDT), HSDT offers an acceptable distribution for shear stress along the thickness and removes the defects of FSDT by presenting acceptable precision without a shear correction parameter. Since the governing equations are two-dimensional and partial differential, the extended Kantorovich method (EKM) and differential quadrature (DQM) have been used to solve the equations. Furthermore, the numeric outcomes were compared with a reference, which shows good harmony between them. Eventually, the effects of small-scale parameters, load, boundary conditions, geometric dimensions, and elastic foundations are studied on maximum nondimensional deflection. It can be concluded that small-scale parameters influence the deflection of the sector nanoplate significantly.
The Explicit Form of the Unitary Representation of the Poincaré Group for Vector-Valued Wave Functions (Massive and Massless), with Applications to Photon Localization and Position Operators
Authors: Jadczyk Arkadiusz
Published: April 2024

We geometrically derive the explicit form of the unitary representation of the Poincaré group for vector-valued wave functions and use it to apply speed-of-light boosts to a simple polarization basis to end up with a Hawton–Baylis photon position operator with commuting components. We give explicit formulas for other photon boost eigenmodes. We investigate the underlying affine connections on the light cone in momentum space and find that while the Pryce connection is metric semi-symmetric, the flat Hawton–Baylis connection is not semi-symmetric. Finally, we discuss the localizability of photon states on closed loops and show that photon states on the circle, both unnormalized improper states and finite-norm wave packet smeared-over washer-like regions are strictly localized not only with respect to Hawton–Baylis operators with commuting components but also with respect to the noncommutative Jauch–Piron–Amrein POV measure.
Impact of Heat Treatment and Building Direction on Tensile Properties and Fracture Mechanism of Inconel 718 Produced by SLM Process
Authors: Heo Seokha , Lim Yujin , Kwak Nawon , Jeon Chami , Choi Moonhee , Jo Ilguk
Published: April 2024

In the selective laser melting (SLM) additive manufacturing process of Inconel 718, the emergence of Laves and δ precipitate phases in the γ matrix during or after heat treatment is a critical consideration. This study comprehensively assesses the microstructures and mechanical properties of Inconel 718 alloy produced through SLM under varied conditions: as-built (AB), homogenization + solution + aging (HSA), homogenization + aging (HA), and solution + aging (SA). Additionally, the impact of building orientation, whether horizontal (H) or vertical (V), is investigated. The AB specimens oriented horizontally display a columnar melt pool structure, with dimensions roughly between 300 and 400 μm. In contrast, the AB specimens aligned vertically show an elongated river-like structure of melt pools, with their sizes approximately at 250 μm. From the detailed microstructural analysis, the findings reveal that the as-built specimens lack γ′ and γ″ precipitates in their microstructure. Conversely, in heat-treated specimens, both the γ′ and γ″ phases are evident. Notably, Inconel 718 alloy specimens subjected to SLM fabrication and SA heat treatment demonstrate optimal mechanical performance. Notably, SA exhibits an average hardness of 476 HV for the horizontal specimen, which is 51.1% higher than that of AB specimens. The morphology and distribution of the δ phase in the γ matrix emerge as decisive factors influencing high-temperature performance. In SA specimens, the dissolution of brittle Laves phases occurs, and the presence of the δ phase at the grain boundary imparts superior properties during high-temperature tensile testing, including excellent yield and ultimate tensile strength. The presence of the granular-δ phase in the SA specimens resulted in a tensile strength of 1422 MPa and a yield strength of 1236 MPa, which are the highest values among all the specimens. SA has a tensile strength of 1120 MPa and a yield strength of 974 MPa at 650 °C.
Morphological and Dimensional Evolution of Nanosized Amorphous Silicon Nitride in α-Fe: Diffusional and Elastic Effects
Authors: Bordère Sylvie , Van Landeghem Hugo-Paul , Redjaïmia Abdelkrim , Gouné Mohamed
Published: April 2024

We present a detailed analysis based on both experimental and 3D modelling approaches of the unique silicon nitride precipitation sequence observed in ferritic Fe-Si alloys upon nitriding. At 570 °C, Si3N4 silicon nitride was shown to form as an amorphous phase into α-Fe ferrite matrix, which is morphologically unstable over time. Precipitates nucleated with a spheroidal shape, then developed a cuboidal shape for intermediate sizes and octapod-like morphology for a longer time. Using transmission electron microscopy, we show that the transition between spheroid and cuboid morphology depended on particle size and resulted from competition between interfacial energy and elastic strain energy. The resulting morphology was then shown to be a cuboid shape whose faces were always parallel to the {100} planes of the α-Fe; the <100> directions of the matrix corresponded to the elastically soft directions. There was a critical size of around 45 nm for which the transition between the cuboid shape and the octapod-like morphology took place. This was characterised by a transformation of quasi-flat facets into concave ones and the development of lobes in the <111> directions of the bcc crystal. To better assess the kinetic effects of diffusion fields and internal stresses on the morphological instability observed, an original 3D model that explicitly coupled phase transformations and mechanical fields was developed and applied. The latter, validated on the basis of model cases, was shown to be able to describe the time-evolution of both chemical and mechanical fields and their interactions in diffusive mass transport. Using a model system, it was shown that the concentration field around the precipitates and the internal stresses played opposing roles in the cuboid to octapod-like morphological instability. This work gives some clarification regarding the morphological evolution of amorphous Si3N4 precipitates, an important point for controlling the mechanical properties of nitrogen steels.
Using Euler Deconvolution as Part of a Mineral Exploration Project
Authors: Cooper G. R. J.
Published: April 2024

Mineral exploration projects can make considerable use of a variety of geophysical techniques and datasets, including magnetic and gravity data. The interpretation of large quantities of data can be very time consuming, so semi-automatic interpretation techniques are often used to provide initial estimates of the parameters (primarily the location and depth) of the sources of anomalies. Euler deconvolution is a commonly used interpretation method for potential fields which has a number of advantages over many other techniques, such as working in the presence of remanent magnetisation, and not being restricted to a particular model such as a contact. A second-order version of Euler’s equation is introduced here, which is much less affected by trends in the data than the standard method and additionally produces depth parabolas, which simplify the interpretation of results. The method was applied to aeromagnetic data from a mineral exploration project in Southern Africa and provided plausible results.
Impacts of Differentially Shaped Silver Nanoparticles with Increasingly Complex Hydrophobic Thiol Surface Coatings in Small-Scale Laboratory Microcosms
Authors: Harper Bryan J. , Engstrom Arek M. , Harper Stacey L. , Mackiewicz Marilyn R.
Published: April 2024

We investigated the impacts of spherical and triangular-plate-shaped lipid-coated silver nanoparticles (AgNPs) designed to prevent surface oxidation and silver ion (Ag+) dissolution in a small-scale microcosm to examine the role of shape and surface functionalization on biological interactions. Exposures were conducted in microcosms consisting of algae, bacteria, crustaceans, and fish embryos. Each microcosm was exposed to one of five surface chemistries within each shape profile (at 0, 0.1, or 0.5 mg Ag/L) to investigate the role of shape and surface composition on organismal uptake and toxicity. The hybrid lipid-coated AgNPs did not result in any significant release of Ag+ and had the most significant toxicity to D. magna, the most sensitive species, although the bacterial population growth rate was reduced in all exposures. Despite AgNPs resulting in increasing algal growth over the experiment, we found no correlation between algal growth and the survival of D. magna, suggesting that the impacts of the AgNPs on bacterial survival influenced algal growth rates. No significant impacts on zebrafish embryos were noted in any exposure. Our results demonstrate that the size, shape, and surface chemistry of AgNPs can be engineered to achieve specific goals while mitigating nanoparticle risks.
Multifunctional Vanadium Nitride-Modified Separator for High-Performance Lithium–Sulfur Batteries
Authors: Liu Sen , Liu Yang , Zhang Xu , Shen Maoqiang , Liu Xuesen , Gao Xinyue , Hou Linrui , Yuan Changzhou
Published: April 2024

Lithium–sulfur batteries (LSBs) are recognized as among the best potential alternative battery systems to lithium-ion batteries and have been widely investigated. However, the shuttle effect has severely restricted the advancement in their practical applications. Here, we prepare vanadium nitride (VN) nanoparticles grown in situ on a nitrogen-doped carbon skeleton (denoted as VN@NC) derived from the MAX phase and use it as separator modification materials for LSBs to suppress the shuttle effect and optimize electrochemical performance. Thanks to the outstanding catalytic performance of VN and the superior electrical conductivity of carbon skeleton derived from MAX, the synergistic effect between the two accelerates the kinetics of both lithium polysulfides (LiPSs) to Li2S and the reverse reaction, effectively suppresses the shuttle effect, and increases cathode sulfur availability, significantly enhancing the electrochemical performance of LSBs. LSBs constructed with VN@NC-modified separators achieve outstanding rate performance and cycle stability. With a capacity of 560 mAh g−1 at 4 C, it exhibits enhanced structural and chemical stability. At 1 C, the device has an incipient capacity of 1052.4 mAh g−1, and the degradation rate averaged only 0.085% over 400cycles. Meanwhile, the LSBs also show larger capacities and good cycling stability at a low electrolyte/sulfur ratio and high surface-loaded sulfur conditions. Thus, a facile and efficient way of preparing modified materials for separators is provided to realize high-performance LSBs.
Gut Microbiota in Patients with Prediabetes
Authors: Chang Wei-Lin , Chen Yu-En , Tseng Hsiang-Tung , Cheng Ching-Feng , Wu Jing-Hui , Hou Yi-Cheng
Published: April 2024

Prediabetes is characterized by abnormal glycemic levels below the type 2 diabetes threshold, and effective control of blood glucose may prevent the progression to type 2 diabetes. While the association between the gut microbiota, glucose metabolism, and insulin resistance in diabetic patients has been established in previous studies, there is a lack of research regarding these aspects in prediabetic patients in Asia. We aim to investigate the composition of the gut microbiota in prediabetic patients and their differences compared to healthy individuals. In total, 57 prediabetic patients and 60 healthy adult individuals aged 18 to 65 years old were included in this study. Biochemistry data, fecal samples, and 3 days of food records were collected. Deoxyribonucleic acid extraction and next-generation sequencing via 16S ribosomal ribonucleic acid metagenomic sequencing were conducted to analyze the relationship between the gut microbiota and dietary habits. Prediabetic patients showed a lower microbial diversity than healthy individuals, with 9 bacterial genera being less abundant and 14 others more abundant. Prediabetic patients who consumed a low-carbohydrate (LC) diet exhibited higher diversity in the gut microbiota than those who consumed a high-carbohydrate diet. A higher abundance of Coprococcus was observed in the prediabetic patients on an LC diet. Compared to healthy individuals, the gut microbiota of prediabetic patients was significantly different, and adopting an LC diet with high dietary fiber consumption may positively impact the gut microbiota. Future studies should aim to understand the relationship between the gut microbiota and glycemic control in the Asian population.
A Bibliometric Analysis of Scientific Publications on Eating Disorder Prevention in the Past Three Decades
Authors: Liao Zhenxin , Scaltritti Martina , Xu Zhihan , Dinh Thu Ngoc Xuan , Chen Jiahe , Ghaderi Ata
Published: April 2024

Background: Eating disorders (EDs) present a growing concern due to their widespread occurrence and chronic course, the low access to evidence-based treatment, and the significant burden they place on the patients and society. This picture justifies intensive focus on the prevention of EDs. The current study provides the first bibliometric analysis of research on the prevention of EDs, focusing on trends and contributions, to prompt further prevention research. Methods: We conducted a bibliometric analysis of publications on the prevention of EDs using the Web of Science database, from 1993 to 2023. Focusing on universal and selective prevention strategies, our study involved a rigorous selection process, narrowing down from 10,546 to 383 relevant papers through manual screening. The analysis utilized the “bibliometrix” R package (version 4.2.2) and Python (version 3.9.6) for data processing, with VOSviewer employed for mapping collaboration networks. Results: Our analysis revealed a consistent annual growth rate of 10.85% in ED prevention research publications, with significant contributions from the “International Journal of Eating Disorders” and some notable authors. The United States emerged as the dominant contributor. The analysis also highlighted key trends, including a surge in publications between 2010 and 2017, and the role of major institutions in advancing research in this field. Discussion: The increasing rate of publications on the prevention of EDs is encouraging. However, the actual number of studies on the prevention of EDs are limited, and the majority of this work is performed by a few research groups. Given the high concentration of publications within a few countries and research groups, increased funding, facilitation of prevention research on a wider scale, and engagement of more researchers and further collaboration are called for.
Dietary Flavonoid Intakes in France Are Linked to Brewed Tea Consumption and to Socioeconomic Status: Analyses of the Third French Individual and National Food Consumption (INCA3) Survey for Children and Adults
Authors: Vieux Florent , Maillot Matthieu , Drewnowski Adam
Published: April 2024

Flavonoids from green and black tea may benefit cardiovascular health. Brewed tea consumption and flavonoid intake in France have not been previously explored. This study assessed the dietary intake of flavonoids among French children and adults, using 3 days’ dietary recall for 3896 persons aged >4 y in the Third French Individual and National Food Consumption Survey (INCA3). Foods consumed by INCA 3 participants were manually matched with the flavonoid content of foods from the French PhenolExplorer database and the US Department of Agriculture expanded flavonoid database (2018 version). The six subclasses of flavonoids were flavan-3-ols, flavanones, anthocyanidins, flavonols, flavones, and isoflavones. Flavonoid intake was stratified by age subgroups (children and adults separately) and examined using socio-demographics and tea consumption patterns. Mean flavonoid intake was 210 mg/d. Flavonoids in the French diet were predominantly flavan-3-ols (147 mg/d), of which tea is the main source. The effects of age, education, income, and socio-professional category (SPC) on flavonoid intake were all significant (p < 0.0001). Brewed tea consumers were 31.88% of French adults and 3.79% of children. Brewed tea consumption and flavonoid intake were highly correlated. The highest brewed tea and flavonoid intakes were found among individuals with the highest SPC and education levels. Flavonoid intake in France was associated with brewed tea consumption and with higher education and income.
NOD2 Responds to Dengue Virus Type 2 Infection in Macrophage-like Cells Interacting with MAVS Adaptor and Affecting IFN-α Production and Virus Titers
Authors: Domínguez-Martínez Diana Alhelí , Pérez-Flores Mayra Silvia , Núñez-Avellaneda Daniel , Torres-Flores Jesús M. , León-Avila Gloria , García-Pérez Blanca Estela , Salazar Ma Isabel
Published: April 2024

In pathogen recognition, the nucleotide-binding domain (NBD) and leucine rich repeat receptors (NLRs) have noteworthy functions in the activation of the innate immune response. These receptors respond to several viral infections, among them NOD2, a very dynamic NLR, whose role in dengue virus (DENV) infection remains unclear. This research aimed to determine the role of human NOD2 in THP-1 macrophage-like cells during DENV-2 infection. NOD2 levels in DENV-2 infected THP-1 macrophage-like cells was evaluated by RT-PCR and Western blot, and an increase was observed at both mRNA and protein levels. We observed using confocal microscopy and co-immunoprecipitation assays that NOD2 interacts with the effector protein MAVS (mitochondrial antiviral signaling protein), an adaptor protein promoting antiviral activity, this occurring mainly at 12 h into the infection. After silencing NOD2, we detected increased viral loads of DENV-2 and lower levels of IFN-α in supernatants from THP-1 macrophage-like cells with NOD2 knock-down and further infected with DENV-2, compared with mock-control or cells transfected with Scramble-siRNA. Thus, NOD2 is activated in response to DENV-2 in THP-1 macrophage-like cells and participates in IFN-α production, in addition to limiting virus replication at the examined time points.
Metabolic-Associated Steatotic Liver Disease (MASLD): A New Term for a More Appropriate Therapy in Pediatrics?
Authors: Mosca Antonella , Pietrobattista Andrea , Maggiore Giuseppe
Published: April 2024

The term “non-alcoholic fatty liver disease” (NAFLD) has been, for a long time, used to describe the spectrum of liver lesions encompassing steatosis, steatohepatitis (NASH), and steatotic cirrhosis [...]
State-of-the-Art Review on Botanical Hybrid Preparations in Phytomedicine and Phytotherapy Research: Background and Perspectives
Authors: Panossian Alexander , Lemerond Terry , Efferth Thomas
Published: April 2024

Background: Despite some evidence supporting the synergy concept, the commonly known assumption that combinations of several herbs in one formulation can have better efficacy due to additive or synergistic effects has yet to be unambiguously and explicitly studied. Study aim: The study aimed to reveal the molecular interactions in situ of host cells in response to botanical hybrid preparations (BHP) intervention and justify the benefits of implementing BHP in clinical practice. Results: This prospective literature review provides the results of recent clinical and network pharmacology studies of BHP of Rhodiola rosea L. (Arctic root) with other plants, including Withania somnifera (L.) Dunal (ashwagandha), (Camellia sinensis (L.) Kuntze (green tea), Eleutherococcus senticosus (Rupr. and Maxim.) Maxim. (eleuthero), Schisandra chinensis (Turcz.) Baill. (schisandra), Leuzea carthamoides (Willd.) DC., caffeine, Cordyceps militaris L., Ginkgo biloba L.(ginkgo), Actaea racemosa L. (black cohosh), Crocus sativus L. (saffron), and L-carnosine. Conclusions: The most important finding from network pharmacology studies of BHP was the evidence supporting the synergistic interaction of BHP ingredients, revealing unexpected new pharmacological activities unique and specific to the new BHP. Some studies show the superior efficacy of BHP compared to mono-drugs. At the same time, some a priori-designed combinations can fail, presumably due to antagonistic interactions and crosstalk between molecular targets within the molecular networks involved in the cellular and overall response of organisms to the intervention. Network pharmacology studies help predict the results of studies aimed at discovering new indications and unpredicted adverse events.
Fair Balance of Prescription Drug Information on Legitimate and Illegitimate Online Pharmacy Websites
Authors: Huhmann Bruce A. , Limbu Yam B.
Published: April 2024

Patients require important information when prescribed medications. For example, the U.S. Food and Drug Administration (FDA) requires that promotional information includes a fair balance of risks and benefits. This study evaluates how well legitimate online pharmacies (LOPs) and illegitimate online pharmacies (IOPs) comply with the spirit of the FDA’s fair balance guidelines by examining the extent and equivalence of risk and benefit information on their websites. This study analyzed the content of 307 online pharmacy websites. Most (90.3%) communicated drug benefits, while 84.7% provided risks. Both risk and benefit information was moderately extensive. Presentation of risks and benefits differed between online pharmacy types. Compared to LOPs, IOPs were more likely to present risk information but also exaggerate benefits. Four in ten online pharmacies presented a fair balance of risks and benefits. However, LOPs (47.4%) were more likely to present a fair balance than IOPs (36.5%). Interestingly, IOPs were more likely to disclose instructions for use and overdose information than LOPs. These findings underscore the need for regulatory guidelines to encourage online pharmacies to present a fair balance of benefit and risk information. Also, pharmacists should develop online approaches to better fulfill their professional responsibility as drug information providers while maintaining their integrity and objectivity.
Dynamic Polarization Patterning Technique for High-Quality Liquid Crystal Planar Optics
Authors: Qin Xinwei , Zhao Keyang , Zhang Xin-jun , Zhou Xiaohong , Huang Wenbin , Chen Linsen
Published: April 2024

The Pancharatnam–Berry (PB)-phase liquid crystal (LC) planar optical elements, featuring large apertures and a light weight, are emerging as the new generation optics. The primary method for fabricating large-aperture LC planar optical elements is through photo-alignment, utilizing polarization laser direct writing. However, conventional polarization direct writing suffers from an inertia-induced stopping step during splicing, leading to suboptimal optical effects. Here, we propose a novel highly efficient method for arbitrary polarization patterning, significantly reducing interface splicing errors in these optical elements. (We call it dynamic polarization patterning technology). This process involves simultaneous mobile splicing and real-time generation of different polarization patterns for exposure, eliminating the inertia-related splicing interruption. As a demonstration, we fabricated a lens with an aperture of approximately 1 cm within 30 min at 633 nm. Furthermore, we developed a 100% fill-factor lens array (3 × 3) with an element lens diameter of approximately 7 mm within 1.5 h at 532 nm. Their focal lengths were uniformly set at 30 cm, demonstrating superior convergence capabilities within their designated working wavelengths, alongside commendable performance in converging light across various other wavelengths. Our measurements confirmed the good focusing performance of these samples. The convergence spot size of the lens deviated by approximately 40% from the theoretical diffraction limit, whereas the lens array exhibited a deviation of around 30%. The dynamic polarization direct writing during uniform platform movement reduced splicing errors to a mere 100–200 nm. The enhancement in imaging quality can be primarily attributed to the innovative use of mobile polarization splicing exposure technology, coupled with the inherent self-smoothing properties of LC molecules. This synergy significantly mitigates the impact of seam diffraction interference.
Improving Tuber Yield of Tiger Nut (Cyperus esculentus L.) through Nitrogen Fertilization in Sandy Farmland
Authors: Zheng Xu , Liu Jianguo , Cheng Zhibo , Sun Yingqiang , Li Luhua , Wang Jiaping
Published: April 2024

The cultivation of tiger nut (Cyperus esculentus L.) on marginal lands is a feasible and effective way to increase food production in Northern China. However, the specific influence of nitrogen fertilizer application on the growth dynamics, tuber expansion, overall yield, and nitrogen use efficiency (NUE) of tiger nuts cultivated on these sandy lands is yet to be fully elucidated. From 2021 to 2022, we conducted a study to determine the effect of N fertilizers on the leaf function morphology, canopy apparent photosynthesis (CAP), tuber yield, and NUE of tiger nut. The results indicate that the tuber yield and NUE are closely related to the specific leaf area (SLA), leaf area index (LAI), leaf nitrogen concentration per area (NA), CAP, and tuber expansion characteristics. Notably, significant enhancements in the SLA, LAI, NA, and CAP during the tuber expansion phase ranging from the 15th to the 45th day under the 300 kg N ha−1 treatment were observed, subsequently leading to increases in both the tuber yield and NUE. Moreover, a maximum average tuber filling rate was obtained under the N300 treatment. These improvements led to substantial increases in the tuber yield (32.1–35.5%), nitrogen agronomic efficiency (NAE, 2.1–5.3%), nitrogen partial factor productivity (NPP, 4.8–8.1%), and nitrogen recovery efficiency (NRE, 3.4–5.7%). Consequently, 300 kg N ha−1 of N fertilizers is the most effective dose for optimizing both the yield of tiger nut tubers and the NUE of tiger nut plants in marginal soils. Structural equation modeling reveals that N application affects the yield and NUE through its effects on leaf functional traits, the CAP, and the tuber filling characteristics. Modeling indicates that tuber expansion characteristics primarily impact the yield, while CAP predominantly governs the NUE. Above all, this study highlights the crucial role of N fertilizer in maximizing the tiger nut tuber yield potential on marginal lands, providing valuable insights into sustainable farming in dry areas.
The Impacts of the Sterilization Method and the Electrospinning Conditions of Nanofibrous Biodegradable Layers on Their Degradation and Hemocompatibility Behavior
Authors: Havlickova Kristyna , Kuzelova Kostakova Eva , Lisnenko Maxim , Hauzerova Sarka , Stuchlik Martin , Vrchovecka Stanislava , Vistejnova Lucie , Molacek Jiri , Lukas David , Prochazkova Renata , Horakova Jana , Jakubkova Sarka , Heczkova Bohdana , Jencova Vera
Published: April 2024

The use of electrospun polymeric biodegradable materials for medical applications is becoming increasingly widespread. One of the most important parameters regarding the functionality of nanofiber scaffolds during implantation and the subsequent regeneration of damaged tissues concerns their stability and degradation behavior, both of which are influenced by a wide range of factors (the properties of the polymer and the polymer solution, the technological processing approach, the sterilization method, etc.). This study monitored the degradation of nanofibrous materials fabricated from degradable polyesters as a result of the sterilization method applied (ethylene oxide and gamma irradiation) and the solvent system used to prepare the spun polymer solution. Aliphatic polyesters PCL and PLCL were chosen for this study and selected with respect to the applicability and handling in the surgical setting of these nanofibrous materials for vascular bandaging. The results revealed that the choice of solvent system exerts a significant impact on degradation during sterilization, especially at higher gamma irradiation values. The subsequent enzyme-catalyzed degradation of the materials following sterilization indicated that the choice of the sterilization method influenced the degradation behavior of the materials. Whereas wave-like degradation was evident concerning ethylene oxide sterilization, no such behavior was observed following gamma-irradiation sterilization. With concern for some of the tested materials, the results also indicated the potential for influencing the development of degradation within the bulk versus degradation from the surface of the material. Both the sterilization method and the choice of the spinning solvent system were found to impact degradation, which was observed to be most accelerated in the case of PLCL (L-lactide-co-caprolactone copolymer) electrospun from organic acids and subsequently sterilized using gamma irradiation. Since we planned to use these materials in cardiovascular applications, it was decided that their hemocompatibility would also be tested. The results of these tests revealed that changes in the structures of the materials initiated by sterilization may exert thrombogenic and anticoagulant impacts. Moreover, the microscopic analysis suggested that the solvent system used in the preparation of the materials potentially affects the behavior of erythrocytes; however, no indication of the occurrence of hemolysis was detected.
Ion-Cross-Linked Hybrid Photochromic Hydrogels with Enhanced Mechanical Properties and Shape Memory Behaviour
Authors: Long Shijun , Chen Fan , Ren Han , Hu Yali , Chen Chao , Huang Yiwan , Li Xuefeng
Published: April 2024

Shape-shifting polymers usually require not only reversible stimuli-responsive ability, but also strong mechanical properties. A novel shape-shifting photochromic hydrogel system was designed and fabricated by embedding hydrophobic spiropyran (SP) into double polymeric network (DN) through micellar copolymerisation. Here, sodium alginate (Alg) and poly acrylate-co-methyl acrylate-co-spiropyran (P(SA-co-MA-co-SPMA)) were employed as the first network and the second network, respectively, to realise high mechanical strength. After being soaked in the CaCl2 solution, the carboxyl groups in the system underwent metal complexation with Ca2+ to enhance the hydrogel. Moreover, after the hydrogel was exposed to UV-light, the closed isomer of spiropyran in the hydrogel network could be converted into an open zwitterionic isomer merocyanine (MC), which was considered to interact with Ca2+ ions. Interestingly, Ca2+ and UV-light responsive programmable shape of the copolymer hydrogel could recover to its original form via immersion in pure water. Given its excellent metal ion and UV light stimuli-responsive and mechanical properties, the hydrogel has potential applications in the field of soft actuators.