bluuebunny/crossref_metadata_2025 huggingface dataset:
The Chicken Thigh Adductor Profundus Free Muscle Flap: A Novel Validated Non-Living Microsurgery Simulation Training Model
Authors: Pafitanis Georgios , Serrar Yasmine , Raveendran Maria , Ghanem Ali , Myers Simon
Published: July 2017

Background Simulation training is becoming an increasingly important component of skills acquisition in surgical specialties, including Plastic Surgery. Non-living simulation models have an established place in Plastic Surgical microsurgery training, and support the principles of replacement, reduction and refinement of animal use. A more sophisticated version of the basic chicken thigh microsurgery model has been developed to include dissection of a type 1-muscle flap and is described and validated here.

Methods A step-by-step dissection guide on how to perform the chicken thigh adductor profundus free muscle flap is demonstrated. Forty trainees performed the novel simulation muscle flap on the last day of a 5-day microsurgery course. Pre- and post-course microvascular anastomosis assessment, along with micro dissection and end product (anastomosis lapse index) assessment, demonstrated skills acquisition.

Results The average time to dissect the flap by novice trainees was 82±24 minutes, by core trainees 90±24 minutes, and by higher trainees 64±21 minutes (P=0.013). There was a statistically significant difference in the time to complete the anastomosis between the three levels of training (P=0.001) and there was a significant decrease in the time taken to perform the anastomosis following course completion (P<0.001). Anastomosis lapse index scores improved for all cohorts with post-test average anastomosis lapse index score of 3±1.4 (P<0.001).

Conclusions The novel chicken thigh adductor profundus free muscle flap model demonstrates face and construct validity for the introduction of the principles of free tissue transfer. The low cost, constant, and reproducible anatomy makes this simulation model a recommended addition to any microsurgical training curriculum.
The Role of Negative-Pressure Wound Therapy in Latissimus Dorsi Flap Donor Site Seroma Prevention: A Cohort Study
Authors: Angspatt Apichai , Laopiyasakul Thana , Pungrasmi Pornthep , Suwajo Poonpissamai
Published: July 2017

Background Donor site seroma is the most common complication after latissimus dorsi (LD) flap harvest. This study aimed to evaluate the efficacy of negative-pressure wound therapy (NPWT) in preventing donor site seroma formation after the harvest of an LD flap for breast reconstruction.

Methods In this prospective matched-pair study, 40 patients in whom an LD flap was harvested for breast reconstruction were enrolled. NPWT was used in 20 patients, and in a control group composed of another 20 patients, the conventional donor site dressing technique was used. Information was collected regarding postoperative complications, the incidence of seroma, total drainage volume, the number of percutaneous seroma aspirations, and the volume aspirated.

Results In the NPWT group, the incidence of seroma formation after drain removal was significantly lower than in the control group (15% vs. 70%; odds ratio=0.07; relative risk, 0.24). Both the mean percutaneous aspirated volume (P=0.004) and the number of percutaneous aspirations (P=0.001) were also significantly lower in the NPWT group. There were no significant differences in the total drainage volume or the duration of wound drainage between the NPWT dressing group and the control group (P>0.05).

Conclusions This study showed that NPWT is a promising tool for reducing the incidence of seroma formation after removing the drain at the donor site after LD flap harvesting. It is a simple and safe technique.
Hair Diameter Variation in Different Vertical Regions of the Occipital Safe Donor Area
Authors: Yun Seon Sik , Park Jae Hyun , Na Young Cheon
Published: July 2017

Background Little is known concerning hair diameter variation within the safe donor area for hair transplantation surgery. Thicker or thinner hair may be needed, depending on the recipient area, hairline design, and the purpose of surgery.

Methods Twenty-seven patients (7 men and 20 women; mean age, 28 years; range, 20–47 years) were included in this study. The midoccipital point was used as the reference point on the horizontal plane at the upper border of the helical rim. The target area width was 15 cm (7.5 cm to the right and left of the reference point) and the height was 8 cm (2 cm above and 6 cm below the reference point). The study area was divided horizontally into 3 5-cm sections (A, B, C) and vertically into 4 2-cm sections (1–4), creating a total of 12 zones. Ten anagen hairs were randomly obtained from each zone and their diameters were measured.

Results Hair diameter in the 4 vertical sections varied significantly, gradually decreasing from sections 1 (superior) to 4 (inferior) in all 3 horizontal sections (A, B, and C).

Conclusions Our results suggest that sections 1 and 2 of the occipital safe donor area would be useful for obtaining thicker hair, such as in procedures to treat male- and female-pattern hair loss, whereas hair from zones 3 and 4 could be useful for transplantation surgery requiring thinner hair, such as eyebrows, eyelashes, and female hairline correction. Our results may be clinically valuable for planning hair transplant surgery and choosing the optimal donor region.
Comparison of Two Different Protocols for the Treatment of Acute Escherichia coli Mastitis in Dairy Cattle
Authors: Hamidi-Sofiani Vahideh , Hamali Hossein , Nofouzi Katayon
Published: July 2017

E-coli mastitis is one of the most frequent causes of environmental mastitis in the dairy cattle worldwide. The purpose of this field study was to compare the efficacy of ceftiofur (HCL) in conjunction with supportive measures versus supportive measures alone for treatment of dairy cows affected with naturally occurring acute form of E. coli mastitis. From January 2014 to December 2016 a total number of 100 cows naturally affected by acute E-coli mastitis randomly were allocated into two groups. A milk sample from the affected quarter was collected for bacteriological tests on the first day of treatment. In group A (control), fifty cows received ceftiofur (HCL) 1mg/5kg/BW, flunixin meglumine 2.2mg/kg, calcium borogluconate 40%, 250ml and hypertonic saline (Nacl 7.2 %,) 5ml/kg. In group B (treatment, n=50), cows received the same drugs mentioned for group A, except ceftiofur (HCL) which replaced by placebo. In the group A, 41cows (82%) and in the group B, 2 cows (4%) were survived respectively. The rates of quarter health recovery in the groups A and B were 31.7% and 0% respectively. The differences between two groups were significant (P≤0.01).
In conclusion our results indicated that treatment of cows affected with naturally occurring acute form of E. coli mastitis without application of effective antibiotic(s) such as ceftiofur (HCL) and fluid therapy almost impossible.
Feeding Traits and Body Dimensions of Lime and Parkote Buffaloes Raised by Small-Scale Farms in Kaski, Nepal
Authors: Hayashi Y. , Shah M.K. , Kumagai H.
Published: July 2017

Thirty farms that raised Lime or Parkote female buffaloes in Kaski were selected for the survey of animal census, feeding traits and body dimensions in the rainy season and the dry season. The average number per farm was 0.76 in Lime and 0.27 in Parkote. The average of age and parity was 8.2 years old and 4.4 in Lime, and 6.6 years old and 2.8 in Parkote, respectively. The mean dry matter (DM) supply of roughage, supplemental feed and total feed was higher in the dry season than in the rainy season (11.8 kg/head/day vs. 10.3 kg/head/day, 1.2 kg/head/day vs. 0.8 kg/head/day, 13.0 kg/head/day vs. 11.1 kg/head/day, respectively, P<0.05). Although the average DM supply of roughage per body weight (BW) and total feed supply per BW had no significant differences between the seasons, the mean DM supply of supplemental feed per BW was higher in the dry season than in the rainy season (0.35% of BW vs. 0.22% of BW, P<0.01). The BW, heart girth (HG) and hip born width (HW) of Parkote were higher than those of Lime (401.7 kg vs. 368.0 kg, 185.7 cm vs. 179.8 cm, 50.4 cm vs. 48.4 cm, respectively, P<0.05). However, the body length, wither height (WH) and criss-cross height showed no significant differences between Lime and Parkote (127.4 cm and 129.8 cm, 118.7 cm and 119.5 cm, 118.0 cm and 119.4 cm, respectively). The BW estimation using body dimensions may play a significant role to know about the buffalo body condition. With the measured BW, HG, WH and HW in this survey, the formulae to estimate BW of Lime and Parkote buffaloes were established.
Priming to Reduce Mand Response Latency
Authors: Misbahuddin Nadia , Mason L.L.
Published: July 2017

This investigation evaluated the effectiveness of a priming intervention to decrease the latency to mand for a five-year-old boy diagnosed with autism spectrum disorder. Parent participation in clinical applied behavior analytic intervention was increased by providing the family members with a home- and community-based priming technique to increase the efficacy of clinical treatment. Using a multiple-baseline design across settings, mand response latency was analyzed as a function of the verbal behavior priming intervention employed by two different caregivers. Results of the study indicate that the caregiver-implemented priming intervention was successful in reducing the child’s latency to vocalize a request, allowing for more efficient use of instructional time.
REGENERATION OF NATURAL SORBENTS CONTAMINATED WITH OIL PRODUCTS IN DIELECTRIC BARRIER DISCHARGE PLASMA
Authors: Gusev Grigory I. , Gushchin Andrey A. , Grinevich Vladimir I. , Osti Anastasiya A. , Izvekova Tatyana V. , Kvitkova Elena Yu.
Published: July 2017

The work is devoted to the study of the recovery processes of the sorption properties of diatomite contaminated with oil products (NP) when it is processed in a dielectric barrier discharge (DBD). Dependences of the sorption capacity on the initial concentration of petroleum products (PP) for the three types of sorbents (diatomite, schungite, zeolite) were determined and working ranges of PP concentrations for the investigated sorbents were established. It was shown that pretreatment of uncontaminated diatomite in DBP led to an increase in its sorption capacity, i.e. there was an "activation" of the sorbent, associated with a change in the properties of its surface, namely, with an increase in the surface of the active centers. The maximum number of cycles of regeneration of the sorbent in DBD, under which it does not lose its physical properties, is eight cycles. Optimum parameters of treatment of contaminated PP diatomite in DBD were established: processing time - 1 min, flow rate of plasma forming gas - 1 l / min, power input into discharge - 8.9 W/cm3. After treatment of the sorbent in the plasma-chemical reactor under optimal conditions, the sorption capacity of diatomite increases by 2.4 times. Thus, based on the results of the conducted studies, it was revealed that when treating contaminated sorbents, the dielectric barrier discharge has a synergistic effect: activates the surface of the sorption material and leads to the destruction of oil products presenting in the sorbent, i.e. this method can be effectively used for the purification of environmentally objects polluted with oil.Forcitation:Gusev G.I., Gushchin A.A., Grinevich V.I., Osti A.A., Izvekova Т.V., Kvitkova E.Yu. Regeneration of natural sorbents contaminated with oil products in dielectric barrier discharge plasma. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N 6. P. 72-76.
VERIFICATION OF NON-CATALYTIC HYDROGEN PEROXIDE DISPROPORTIONATION MECHANISM BY THERMODYNAMIC ANALYSIS OF ONE-ELECTRON REDOX REACTIONS
Authors: Chumakov Anton A. , Batalova Valentina N. , Slizhov Yuriy G. , Minakova Tamara S.
Published: July 2017

There is two-electron transfer during the process of hydrogen peroxide decomposition into water and oxygen. The detailed mechanism of non-catalytic hydrogen peroxide disproportionation is not verified until now. We assumed that any poly-electron redox process is a complex and consists of one-electron redox reactions. We have formulated equations of possible one-electron transfers during hydrogen peroxide disproportionation. Based on known laws and equations of thermochemistry we calculated standard thermodynamic functions for a total reaction and each one-elect-ron redox reaction using reference values of standard thermodynamic functions of reagents and products of reactions. Results show that the total reaction leads to significant decrease in Gibbs free energy -246.0 kJ/mol in gas phase but there is increase +39.9 kJ/mol in Gibbs free energy during the first proposed step. It is substantiation for known dependence of hydrogen peroxide dismutation kinetics at thermal, photochemical or catalytic activation. The first proposed step of non-catalytic process is one-electron plus one-proton transfer in thermally or photochemically activated dimeric hydrogen peroxide associate (H2O2)2 with simultaneous generation of hydroperoxyl HO2• and hydroxyl HO• free radicals and water molecule. There is thermodynamic argumentation for radical chain mechanism of hydrogen peroxide disproportionation after the activation. We made the graphic illustration of thermodynamically supported scheme of non-catalytic hydrogen peroxide decomposition. There is a cyclic alternation of two radical-molecular interactions during the hydrogen peroxide chain decomposition. The hydroxyl radical generates the hydroperoxyl radi-cal from a hydrogen peroxide molecule and then the hydroperoxyl radical interacts with a next hydrogen peroxide molecule followed by the hydroxyl radical generation. Interactions between the homonymic or heteronymic free radicals are the reactions of chain breaking.Forcitation:Chumakov A.A., Batalova V.N., Slizhov Yu.G., Minakova T.S. Verification of non-catalytic hydrogen peroxide disproportionation mechanism by thermodynamic analysis of one-electron redox reactions. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N 6. P. 40-44.
SYSTEM (LiF)2 – (NaF)2 – (NaCl)2 – Na3FSO4
Authors: Verdiev Nadinbeg N. , Alkhasov Alibek B. , Omarova Sabina M. , Magomedbekov Uhumaali G. , Gasangadzhieva Umukusum G. , Dvoryanchikov Vasiliy I.
Published: July 2017

With the differential-thermal method of physico-chemical analysis the stable tetrahedron (LiF)2 – (NaF)2 – (NaCl)2 – Na3FSO4 of four-component mutual system Li, Na // F, Cl, SO4. It was established that the system is eutectic one.The eutectic crystallizes at 543 °C. The system Li, Na // F, Cl, SO4 is characterized by the presence of three compounds: one detectice (Na3FSO4) and two peritectically compounds Li2Na4(SO4)3, LiNaSO4. Four-component reciprocal systems, in the elements of faceting of which include irreversibly-reciprocal or singular three-component systems without compounds, are divided, as a rule, into three tetrahedra. In this case, the composition diagrams of the Li, Na / F, Cl, SO4 system are decomposed taking into account the incongruent and congruent melting compounds, resulting in the revealing the seven tetrahedra.: 1. (LiF)2 – (LiCl)2 – Li2SO4 – (NaCl)2; 2. (LiF)2 – Li2SO4 – (NaCl)2 – Na3FSO4; 3. Li2SO4 – Na2SO4 – (NaCl)2 – Na3FSO4; 4. (LiF)2 – (NaF)2 – (NaCl)2 – Na3FSO4; 5. Li2Na4(SO4)3 – LiNaSO4 – Na3FSO4 – (NaCl)2; 6. LiNaSO4 – Na3FSO4 – Li2SO4 – (NaCl)2; 7. Li2Na4(SO4)3 – Na3FSO4 – Na2SO4 – (NaCl)2. The theoretical analysis of the granular elements of these tetrahedra carried out by us, and later the investigation of the DTA of single compounds in each tetrahedron, shows that the nonvariant points from tetrahedra formed with the participation of incongruent melting compounds migrate to the tetrahedra bordering them with inversion into quaternary peritectics. The lack nonvariant points in the tetrahedra formed with the participation of the incongruent melting compounds: Li2Na4(SO4)3 – LiNaSO4 – Na3FSO4 – (NaCl)2; LiNaSO4 – Na3FSO4 – Li2SO4 – (NaCl)2; Li2Na4(SO4)3 – Na3FSO4 – Na2SO4 – (NaCl)2, confirmed by the absence in the thermograms of DTA unit composition of these tetrahedrons thermoeffect joint crystallization of four phases. In this study, a tetrahedron (LiF)2 - (NaF)2 - (NaCl)2 - Na3FSO4 was selected for experimental investigation, in a composition that does not include peritectic compounds and only one eutectic composition is localized in this system.The choice of this system for experimental research is also due to the fact that its composition includes lithium fluoride, which has a relatively large enthalpy of phase transition, which is one of the determining factors in the selection of heat accumulators, heat carriers for devices that store heat and solar energy.Also the system includes salts widely used in the pulp and paper, textile, food, construction industries. Investigation of phase equilibrium diagrams of such systems allows expanding the areas of application of low melting eutectic compounds.Forcitation:Verdiev N.N., Omarova S.M., Alkhasov A.B., Magomedbekov U.G., Gasangadzhieva U.G., Dvoryanchikov V.I. System(LiF)2 – (NaF)2 – (NaCl)2 – Na3FSO4. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N 6. P. 77-82.
PURIFICATION FEATURES OF CARBON NANOTUBES FROM IMPURITIES AFTER THEIR SYNTHESIS
Authors: Tabulina Lyudmila V. , Rusalskaya Tamara G. , Shulitsky Boris G. , Komissarov Ivan V. , Shaman Yuri P. , Carosa Anatoliy G.
Published: July 2017

The influence of multi-stage liquid-phase chemical treatment of carbon nanotubes obtained CVD method on the quantitative and qualitative composition of their array was studied, as well as the state of their structures for the selection of optimal conditions for cleaning this material from impurities. The synthesis of carbon nanotubes was carried out using a catalyst based on iron oxides and molybdenum deposited on finely dispersed alumina and methane as a carbon reagent. The act of chemical reagents on the degree of purification and the state of the structure of the walls of carbon nanotubes was studied at all stages of the multistage chemical treatment of the obtained material. The complete purification cycle of synthesized carbon nanotubes from associated impurities included treatments with concentrated aqueous solutions of such chemicals as hydrochloric acid (concentration 11.5 M), hydrogen peroxide (concentration 8.8 M), nitric acid (concentration 15 M). Changes in the qualitative and quantitative compositions, structural characteristics of materials, obtained in stages in the multi-stage method used to clean carbon nanotubes from impurities, have been studied by means of physicochemical methods such as X-ray energy-dispersive spectroscopy, Raman spectroscopy, and transmission electron microscopy. It has been established that for efficient cleaning of carbon nanotubes, which are small-walled nanotubes, it is necessary to carry out sequential treatment of raw material with solutions of hydrochloric acid and hydrogen peroxide. A positive effect on the cleaning quality of the small-walled carbon nanotubes synthesized by the CVD method is provided by finishing with a solution of nitric acid. In this case, it is necessary to optimize the duration of the preliminary stage using a hydrogen peroxide solution to prevent the destructive action of nitric acid on the structure of carbon nanotubes.Forcitation:Tabulina L.V., Rusalskaya T.G., Shulitsky B.G., Shaman Y.P., Komissarov I.V., Carosa A.G. Purification features of carbon nanotubes from impurities after their synthesis. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N 6. P. 89-94.
IMPACT OF TRANSFER PROCESSES OF LIQIUD CATHODE COMPONENTS ON PHYSICAL-CHEMICAL PARAMETERS OF ATMOSPHERIC PRESSURE DC DISCHARGE
Authors: Kulentsan Anton L. , Shutov Dmitriy A. , Rybkin Vladimir V.
Published: July 2017

Experimental data on glow discharge parameters of atmospheric pressure in air with cathodes from distilled water and water containing ions of potassium, sodium and copper (II) are obtained. Chlorides of the corresponding salts were used. The current range was 20-60 mA, and the solution concentrations were -0.1-0.4 mol/l. The cathode drops of the potential and the electric fields in the plasma are determined by the mobile anode method. With emission spectroscopy by modeling the unresolved rotational structure of the emission bands of the second positive system of nitrogen molecules, gas temperatures were found. On the basis of these data, the total concentrations of the particles, the reduced electric field strengths, were found. It is found that the increase in the discharge current leads to a decrease in the cathode drops of the potential, the strengths of the electric fields, and the reduced field strengths. At the same time, the temperature of the gas was practically independent on the discharge current and it was 1600 ± 150 K. By numerical solution of the Boltzmann equation for electrons, electron energy distribution functions, mean energies and electron concentrations and rate constants of the processes occurring under the action of electron impact were determined. An estimate is made of the contribution to the formation of charged particles in the plasma of ionization processes of metal atoms that appear in the gas phase as a result of non-equilibrium transfer from the liquid cathode. It is shown that for molar fractions of metal atoms of 10-4 and higher, ionization is completely determined by collisions of electrons with metal atoms, rather than with molecules of the main plasma-forming gas. It is also shown that discharges with cathodes containing salt solutions have smaller values of cathode potential drops.Forcitation:Kuletsan A.L., Shutov D.A., Rybkin V.V. Impact of transfer processes of liqiud cathode components on physical-chemical parameters of atmospheric pressure dc discharge. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N 6. P. 52-58.
"... med adelig proces ...". Odense som centralt orienteringspunkt belyst gennem adelige bryllupper og begravelser ca. 1560-1670
Authors: Seesko Per
Published: July 2017

I denne artikel undersøges Odenses historiske betydning som centralt orienteringspunkt på Fyn gennem en fokus på den fynske adels bryllupper og begravelser i byen i perioden ca. 1560-1670. Der lægges særligt vægt på, hvordan den betydning en udefrakommende gruppe, som den fynske adel, tillagde et centralt orienteringspunkt som Odense, kunne afspejles i dens tilstedeværelse i byens offentlige rum.
Fregatter på Vestindiensejlads. Et studie af skibskonstruktion og ekvipering af fregatter til langfart
Authors: Jørgensen Ida Christine
Published: July 2017

Når de danske handelsskibe stævnede ud mod de dansk vestindiske øer, var de ikke altid alene. Især i perioder, hvor krige hærgede, måtte flådens fregatter yde beskyttelse mod kapere og andre nationers krigsskibe, så den indbringende handel kunne fortsætte. Det er netop disse fregatter, denne artikel vil sætte fokus på. Men ikke på deres sejladser over Atlanten og ikke på deres opgaver i de tropiske farvande. Længe før fregatterne overhovedet var klar til at sætte kursen mod kolonierne, var der blevet gjort mange tanker om skibenes konstruktion, stand, armering og ekvipering. Dette skete hos en kommission, der har efterladt sig en stor mængde kilder, der i dag kan fortælle os om alle de forberedelser, der skulle til, når en fregat skulle sendes på langfart. Konstruktionskommissionen stod for alle diskussioner og beslutninger vedrørende statens skibsbyggeri, og deres efterladte protokoller giver et spændende indblik i dette arbejde.
Danmarks Neapel. Ebeltofts udvikling til turistdestination – fra landliggere til moderne masseturisme
Authors: Glerup Møller Lea
Published: July 2017

I slutningen af 1800-tallet var Ebeltoft en beskeden købstad tilsyneladende uden økonomiske udviklingsmuligheder. Dette ændrede sig i løbet af 1880’erne, da en række indflydelsesrige borgere blev opmærksomme på Ebeltofts potentiale som feriedestination. Hermed begyndte en udvikling, der i løbet af det 20. århundrede skulle gøre Ebeltoft til en af Danmarks bedste kendte turistdestinationer. Hvordan imødekom Ebeltoft den stigende tilstrømning af gæster for at opfylde deres skiftende behov for passende adspredelse under opholdet, og hvilke strategier lå bag? Denne udvikling er omdrejningspunktet for nærværende artikel.
A Case of Lactate Containing Peritoneal Dialysis Solution Induced Lactic Acidosis Corrected by Changing to Hemodialysis
Authors: Kim Eun Bin , Kim Ki Seung , Lee Su Mi , Son Young Ki , Kim Seong Eun , An Won Suk
Published: July 2017

Elevated lactate levels are associated with acute illnesses, and the mortality is high. Here, we report a case of lactate-containing peritoneal dialysis (PD) solution inducing lactic acidosis corrected by changing to hemodialysis (HD). This 70-year-old female patient was treated with PD 8 months previously for end-stage renal disease caused by diabetes mellitus. She was admitted complaining of general weakness. Initial lactate level was 22.1 mg/dL and increased to 62.4 mg/dL showing high anion gap metabolic acidosis and compensatory hyperventilation. There are no definite causes of lactic acidosis besides the use of PD solutions containing a lactate component. The patient's lactate level was decreased after temporarily changing the dialysis modality to HD. Her lactate level was increased again after restarting PD, and decreased to normal after restarting HD. We report this case because physicians should consider lactate-containing PD solution as a possible cause of lactic acidosis.
A Case of Cardiac Arrest due to Multivessel, Diffuse Coronary Spasm in Moyamoya Disease
Authors: Choi Young Min , Choi Jung Woo , Kang Dong Ho , Kwak Choong Hwan , Hwang Jin Yong , Koh Jin Sin
Published: July 2017

Moyamoya disease is characterized by progressive stenosis of the distal portion of the internal carotid arteries and fragile collateral vessels in the brain. The precise pathogenesis is still not known. Although extracranial vessel involvement is very rare, coronary arterial involvement has recently been reported. Here, we report a case of diffuse, multivessel coronary spasm leading to cardiac arrest and myocardial infarction in a 47-year-old man with moyamoya disease with no underlying emotional or physical stress.
Hemodynamic Effects of Co-administration of Midazolam during Anesthesia Induction with Propofol and Remifentanil in Hypertensive Patients
Authors: Kim Ju Deok , Kim Joo Won , Kung His Chiang , Kang Jun Hong , Shin Hye Young , Kim Doo Sik , Ryu Sie Jeong , Kim Kyung Han
Published: July 2017

Objectives Propofol, midazolam and remifentanil are commonly used for clinical anesthesia. We compared the effects of midazolam-propofol-remifentanil and propofol-remifentanil on hemodynamic responses during anesthesia induction in hypertensive patients. Methods Seventy-six hypertensive patients with ASA II-III were assigned to receive midazolam-propofol (group MP; n = 38) or propofol (group P; n = 38). Anesthesia was induced with midazolam 0.03 mg/kg (group MP) or saline 0.03 ml/kg (group P). After two minutes, propofol 1.0 mg/kg (group MP) or 1.5 mg/kg (group P) i.v. bolus was administered. Simultaneously, 4 ng/ml of remifentanil target controlled infusion (TCI) was administered in both groups. Anesthesia was maintained using sevoflurane and 2 ng/ml of remifentanil TCI. Systolic, diastolic, and mean blood pressure (SBP, DBP, and MBP) and heart rate (HR) were measured before induction, 2 min after midazolam or normal saline, 2 min after propofol, 1 min after rocuronium, and immediately, 1 min, 2 min, and 3 min after intubation. Results SBP, DBP, and MBP decreased after propofol administration and increased immediately after intubation in both groups ( P < 0.05). After intubation, SBP, DBP, and MBP decreased more than baseline values in either group. Although the overall BP of Group P was lower than that of Group MP, there were no significant differences except for SBP at 2min after intubation ( P < 0.05). HR was no significant difference in either group. Conclusion Our results suggest that midazolam-propofol-remifentanil has similar hemodynamic effect with propofol-remifentanil during anesthesia induction in hypertensive patients.
An Overview of the Clinical Efficacy and Safety of Tissue Selective Estrogen Complex: From the Selective Estrogens, Menopause, and Response to Therapy (SMART) Trials
Authors: Chun Sung Wook
Published: July 2017

Hormone therapy (HT) is the most effective treatment for menopausal symptoms, and reduces both spinal and non-spinal postmenopausal osteoporotic fractures. However, a Women's Health Initiative (WHI) trial revealed that progestin-containing HT is associated with higher incidences of breast cancer and coronary heart disease than those associated with placebo. Tissue selective estrogen complex (TSEC) is a novel progestin-free HT option composed of conjugated estrogens (CE) and a selective estrogen receptor modulator. CE at a dose of 0.45 mg combined with 20 mg of bazedoxifene was the first TSEC medication approved in the United States and Korea for women with moderate to severe menopause-related vasomotor symptoms (VMS) and for preventing postmenopausal osteoporosis. This review summarizes the clinical efficacy, safety, and tolerability of TSEC as obtained from the five SMART clinical trials.
A Case of Steroid Resistant Minimal Change Disease Associated with Portal Vein Thrombosis Treated by Combined Immunosuppressive Agents
Authors: Jung Hyo Jin , Lee Su Mi , Rha Seo Hee , Kim Seong Eun , Son Young Ki , Kim Ki Seung , An Won Suk
Published: July 2017

Minimal change disease (MCD) is a common cause of nephrotic syndrome and relatively well responds with steroid treatment. However, nearly half of patients with MCD experience recurrence of nephrotic syndrome. Thromboembolic events including renal vein thrombosis may occur in patients with MCD, but portal vein thrombosis rarely occurs. We experienced a case of frequent relapse/steroid dependent MCD with nephrotic syndrome progressed to steroid resistance associated with portal vein thrombosis. This patient showed complete remission of MCD and resolution of portal vein thrombosis after treatment with corticosteroid, cyclosporine, mycophenolate mofetil, and anticoagulant.
Le Service des archives de l’Université de Montréal : une formidable école ! (Témoignage)
Authors: Lalonde Michel
Published: July 2017

Ce texte évoque l’influence marquante que la direction et le personnel du Service des archives de l’Université de Montréal ont eu sur l’auteur, apprenti-archiviste au tournant des années 1970-1980. En plus de connaissances de la discipline archivistique et d’expériences professionnelles, il retient de son passage au Service le développement d’amitiés durables ainsi que d’un réseau professionnel.
La Division de la gestion de documents et des archives de l’Université de Montréal : un regard d’outre-Atlantique
Authors: Servais Paul
Published: July 2017

Après avoir brièvement souligné les caractéristiques partagées et spécifiques inhérentes à un service d’archives d’université, ce texte met en lumière le rôle de la Division de la gestion de documents et des archives de l’Université de Montréal comme modèle, celui qu’elle joue comme incubateur ou pépinière d’archivistes et celui qu’elle assume comme moteur de la réflexion pour la communauté archivistique internationale.
« La grande blessure »
Authors: Henzi Sarah
Published: July 2017

À l’heure où la littérature sur les pensionnats et la réconciliation est immense, cet article porte sur certaines interventions littéraires et cinématographiques autochtones issues du Québec. À travers une discussion sur les oeuvres d’An Antane Kapesh (Je suis une maudite sauvagesse, 1976, etQu’as-tu fait de mon pays ?1979), les courts métragesL’amendementde Kevin Papatie (2007) etLa mallette noire(2014) de Caroline Monnet et la poésie de Natasha Kanapé Fontaine, cet article analyse la représentation des conflits, physiques et émotionnels au sein du projet artistique, comme étant une « action esthétique » (Robinson et Martin) : il s’agit d’interventions visant à offrir des formes alternatives d’action politique, de transformation sociale et de guérison.
The ability of Reciproc instruments to reach full working length without glide path preparation: a clinical retrospective study
Authors: Bartols Andreas , Robra Bernt-Peter , Walther Winfried
Published: July 2017

Background

Reciproc instruments are the only contemporary root canal instruments where glide path preparation is no longer strictly demanded by the manufacturer. As the complete preparation of root canals is associated with success in endodontic treatment we wanted to assess the ability and find predictors for Reciproc instruments to reach full working length (RFWL) in root canals of maxillary molars in primary root canal treatment (1°RCTx) and retreatment (2°RCTx) cases.

Methods

This retrospective study evaluated 255 endodontic treatment cases of maxillary molars. 180 were 1°RCTx and 75 2°RCTx. All root canals were prepared with Reciproc instruments. The groups were compared and in a binary logistic regression model predictors for RFWL were evaluated.

Results

A total of 926 root canals were treated with Reciproc without glide path preparation. This was possible in 885 canals (95.6%). In 1°RCTx cases 625 of 649 (96.3%) canals were RFWL and in 2°RCTx cases 260 of 277 (93.9%). In second and third mesiobuccal canals (MB2/3) 90 out of 101 (89.1%) were RFWL with Reciproc in 1°RCTx and in the 2°RCTx treatment group 49 out of 51 cases (96.1%). In mesio-buccal (MB1) canals “2°RCTx” was identified as negative predictor for RFWL (OR 0.24 (CI [0.08–0.77])). In MB2/3 canals full working length was reached less often (OR 0.04 (CI [0.01–0.31])) if the tooth was constricted and more often if MB2/3 and MB1 canals were convergent (OR 4.60 (CI [1.07–19.61])).

Discussion

Using Reciproc instruments, the vast majority of root canals in primary treatment and retreatment cases can be prepared without glide path preparation.
Turismo de base comunitária na favela Santa Marta (RJ): oportunidades sociais, econômicas e culturais
Authors: Mano Apoena Dias , Mayer Verônica Feder , Fratucci Aguinaldo Cesar
Published: July 2017

Propósito justificado do tema: Debates a respeito das motivações e impactos dos processos de turistificação de favelas vêm sendo realizados nos últimos anos, em diversos campos de estudos e em diversos países. Objetivo: Este artigo apresenta os resultados de uma pesquisa realizada na favela Santa Marta, cidade do Rio de Janeiro, com a intenção de se investigar os efeitos do turismo de base comunitária nas atividades turísticas que ocorrem naquele local. Metodologia/Design: Para isso, foram realizados dois estudos: o primeiro, quantitativo, investigou as percepções de turistas e de moradores sobre aspectos positivos e negativos do turismo; o segundo, qualitativo, dedicou-se a compreender a cadeia de turismo de base comunitária local. Resultados e originalidade do documento: Os resultados indicam que alternativas de turismo baseadas no empoderamento e no protagonismo dos moradores podem tornar a prática turística em favelas socialmente mais comprometida. A contribuição central da pesquisa é a reflexão sobre a experiência do Turismo de Base Comunitária em ambientes urbanos como as favelas, indicando que a participação ativa dos moradores pode modificar o perfil do turismo, potencializando as trocas culturais em detrimento da simples observação da pobreza. O amadurecimento desse tipo de rede de turismo comunitário está relacionado à desconstrução de estereótipos relacionados às favelas e à obtenção de impactos socioeconômicos e culturais mais positivos e significativos em comparação às formas mais tradicionais de turismo.
Model Integrasi Keputusan Lokasi, Perutean Kendaraan, dan Pengendalian Persediaan Pada Sistem Rantai Pasok Tiga Eselon
Authors: Saragih Nova , Nur Bahagia Senator , Suprayogi Suprayogi , Syabri Ibnu
Published: July 2017

Keputusan lokasi, perutean kendaraan, dan kebijakan persediaan merupakan keputusan yang saling terkait satu dengan yang lain. Keputusan pengendalian persediaan, seperti ukuran lot pemesanan dan frekuensi pemesanan akan mempengaruhi baik itu ongkos persediaan dan ongkos transportasi. Sebagai contoh, pengiriman dalam kuantitas yang sedikit dan frekuensi yang sering menyebabkan pengurangan ongkos persediaan tetapi membutuhkan tambahan ongkos transportasi. Selanjutnya, keputusan perutean dan keputusan pengendalian persediaan akan mempengaruhi keputusan pemilihan lokasi sebab pemilihan lokasi ditentukan berdasarkan kriteria ongkos sistem minimum. Kegagalan dalam melibatkan ongkos persediaan dan ongkos transportasi ke dalam pertimbangan ketika memilih lokasi dapat menyebabkan sub-optimalitas sebab keputusan pemilihan lokasi memiliki dampak yang besar pada ongkos persediaan dan ongkos transportasi. Oleh karena itu, bagaimana memilih lokasi, menentukan rute kendaraan, dan mengendalikan persediaan yang optimal menjadi isu yang penting dalam merancang sebuah sistem logistik. Penelitian ini mengembangkan model integrasi yang secara simultan mengoptimisasikan keputusan lokasi, rute kendaraan, dan pengendalian persediaan pada sistem rantai pasok tiga eselon yang belum pernah dikembangkan sebelumnya. Entitas yang terlibat dalam rantai pasok kajian terdiri dari satu Pemasok, multi Depot, dan multi Ritel. Karakteristik permintaan yang dipertimbangkan dalam penelitian ini bersifat probabilistik dan jumlah produk terdiri dari satu produk. Model integrasi yang dikembangkan selanjutnya dipecahkan dengan metode optimal dan metode heuristik. Setelah dilakukan perbandingan dengan model dekomposisi diperoleh kesimpulan bahwa model integrasi menghasilkan ongkos total sistem yang lebih kecil.
Model Optimisasi Robust untuk Mengatasi Ketidaktentuan Estimasi Durasi Operasi pada Masalah Penjadwalan Ruang Operasi Rumah Sakit
Authors: Chaerani Diah , Royana Ija , Hertini Elis
Published: July 2017

Masalah penjadwalan ruang operasi di rumah sakit merupakan masalah keragaman durasi operasi yang memerlukan penjadwalan untuk mengurangi tingkat kesibukan ruang operasi.  Masalah yang harus diselesaikan dalam penjadwalan ruang operasi adalah bagaimana menempatkan pasien ke dalam blok ruang operasi yang tersedia secara optimal untuk meminimumkan waktu tunggu pasien. Masalah ini dapat disajikan dalam sebagai masalah optimisasi dalam formulasi mixed integer linear programming (MILP). Pada prakteknya sering terjadi ketidaktentuan estimasi durasi operasi yang dapat mengakibatkan jadwal operasi tidak berjalan sesuai perencanaan awal, sehingga pasien tidak dapat dioperasi sesuai dengan waktu yang telah ditentukan. Dalam makalah ini dikaji pemodelan masalah optimisasi tak tentu dengan menggunakan teknik pemodelan Optimisasi Robust (OR) dalam hal mengatasi ketidaktentuan estimasi durasi operasi pada masalah penjadwalan ruang operasi rumah sakit. Dalam metodologi OR diperkenalkan Robust Counterpart (RC), dimana  tujuan utama yang ingin dicapai adalah menguji level robustness dengan cara menguji formulasi model robust counterpart yang dihasilkan apakah dapat direpresentasikan dalam jenis kelas masalah optimisasi yang dapat terjamin sebagai kelas masalah yang computationally tractable. Pemilihan jenis himpunan taktentu untuk merepresentasikan data taktentu yang terlibat dalam pemodelan sangat menentukan, untuk memastikan  apakah formulasi robust counterpart yang diperoleh merupakan masalah yang computationally tractable atau tidak. Dapat disimpulkan bahwa model RC yang diperoleh termasuk dalam kelas masalah yang computatioonally tractability, dalam hal ini model tak tentu dapat direpresentasikan dalam formulasi model optimisasi dalam bentuk linear programming (untuk box uncertainty set) dan conic quadratic programming (untuk ellipsoidal uncertainty set).
A Materials Roadmap to Functional Neural Interface Design
Authors: Wellman Steven M. , Eles James R. , Ludwig Kip A. , Seymour John P. , Michelson Nicholas J. , McFadden William E. , Vazquez Alberto L. , Kozai Takashi D. Y.
Published: July 2017

Advancements in neurotechnologies for electrophysiology, neurochemical sensing, neuromodulation, and optogenetics are revolutionizing scientific understanding of the brain while enabling treatments and preventative measures for a variety of neurological disorders. The grand challenge in neural interface engineering is to seamlessly integrate the interface between neurobiology and engineered technology to record from and modulate neurons over chronic timescales. However, the biological inflammatory response to implants, neural degeneration, and long‐term material stability diminishes the quality of the interface overtime. Recent advances in functional materials are aimed at engineering solutions for chronic neural interfaces, yet, the development and deployment of neural interfaces designed from novel materials have introduced new challenges that have been largely unaddressed. Many engineering efforts that solely focus on optimizing individual probe design parameters, such as softness or flexibility, downplay critical multidimensional interactions between different physical properties of the device that contribute to overall performance and biocompatibility. Moreover, the use of these new materials present substantial new difficulties that must be addressed before regulatory approval for use in human patients is achievable. In this review, the interdependence of different electrode components is highlighted to demonstrate the current material‐based challenges facing the field of neural interface engineering.
Selective Synthesis of Silacycles by Borane‐Catalyzed Domino Hydrosilylation of Proximal Unsaturated Bonds: Tunable Approach to 1,n‐Diols
Authors: Shin Kwangmin , Joung Seewon , Kim Youyoung , Chang Sukbok
Published: July 2017

The tris(pentafluorophenyl)boron‐catalyzed domino hydrosilylation of substrates carrying unsaturated functionalities in a proximal arrangement is presented to produce silacycles. Excellent levels of efficiency and selectivity were achieved in the cyclization by the deliberate choice of the hydrosilane reagents. The key to successful cyclic hydrosilylation is the reactivity enhancement of the second intramolecular hydrosilylation by a proximity effect. Not only dienes but also enones, enynes, ynones and enimines readily afford medium‐sized silacycles under convenient and mild conditions. The cyclization proceeds with acceptable diastereoselectivity mainly controlled by the conformational bias towards inducing additional stereogenic centers. The silacycles obtained from this reaction were converted to 1,n‐diols or 1,n‐amino alcohols upon oxidation, thus rendering the present cyclization a powerful tool for accessing synthetically valuable building blocks.

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Synthesis of an Environmentally Friendly Alkyl Carbonate Electrolyte Based on Glycerol for Lithium‐Ion Supercapacitor Operation at 100 °C
Authors: Salari Maryam , Cooper Benjamin G. , Zhang Heng , Grinstaff Mark W.
Published: July 2017

The increased number of electrical energy storage (EES) systems utilized in everyday products along with the demand for more reliable and safer products that provide high energy densities with faster response times over an extended range of temperatures are catalyzing advances across all areas of EES technology. Here, the preparation and performance evaluation at 100 °C of a high voltage lithium‐ion supercapacitor (LIC), comprised of activated carbon electrodes and a novel, environmentally friendly alkyl carbonate electrolyte based on glycerol containing 1 m LiTFSI, are reproted. Use of this ethoxy propylene carbonate electrolyte affords a high capacitance level with notable electrochemical performance including a specific capacitance of 162 F g−1 at 1 mV s−1, energy density of 14.2 Wh kg−1 at 2 A g−1, and power density of 7.5 kW kg−1 at 10 A g−1 at 100 °C. The performance of this LIC at 100 °C is compared to a conventional ethylene carbonate‐dimethyl carbonate LIC operating only at 25 °C as conventional organic and aqueous electrolytes do not allow safe operation at such an elevated temperature. Finally, insight into the increased Li+‐carbon intercalation mechanism is provided, observed with the system, leading to the enhanced electrochemical performance.
Metallfreie Diborierung von Nitrilen durch Aktivierung eines elektronenreichen Diborans
Authors: Frick Markus , Kaifer Elisabeth , Himmel Hans‐Jörg
Published: July 2017

Diborierungen von ungesättigten organischen Molekülen sind äußerst nützliche Reaktionen in der Synthesechemie. Hier berichten wir über die erste Diborierung eines Nitrils durch ein elektronenreiches Diboran, vermittelt durch ein elektrophiles Boran. Die Reaktion ist metallfrei und alle Reagenzien sind leicht verfügbar.
Congenital unilateral renal agenesis: Prevalence, prenatal diagnosis, associated anomalies. Data from two birth‐defect registries
Authors: Laurichesse Delmas Hélène , Kohler Monique , Doray Bérénice , Lémery Didier , Francannet Christine , Quistrebert Jocelyn , Marie Cécile , Perthus Isabelle
Published: July 2017

Background

The different mechanisms leading to a solitary kidney should be differentiated because the long‐term outcome might be different. The fetal period is the best moment to make a true diagnosis of congenital unilateral renal agenesis (URA). The objective was to determine the prevalence of URA at birth. The secondary objectives were to describe the evolution of sensitivity of prenatal diagnosis over time and the different forms of URA (isolated and associated with other malformations) detected up to 1 year.

Methods

The cases were retrospectively identified through two French population‐based birth defect registries (Auvergne and Bas‐Rhin) between 1995 and 2013. Stillbirths and fetuses up to 22 weeks of gestation and infants up to 1 year old with URA were included.

Results

A total of 177 cases of URA were registered. The prevalence at birth was 4.0/10,000. The overall prenatal prevalence was 3.6/10,000 (isolated URA: 2.8/10,000). URA were isolated (59.9%), associated with isolated contralateral congenital anomaly of kidney or urinary tract (CAKUT) (7.3%) and with other extra‐renal anomalies (32.8%). The total proportion of contralateral CAKUT was 15%. Only three cases presented an aneuploidy, prenatally detected and conducting to a termination of pregnancy. The sensitivity of prenatal diagnosis improved over time (from 54.2% in 1995 to 1997 to 95.8% in 2010 to 2013; p = 0.002).

Conclusion

Our study provides estimates of prevalence of URA at birth. A longitudinal cohort from the antenatal period to puberty should be performed to determine the prognosis of the contralateral kidney among these children with isolated, associated with contralateral CAKUT and URA with extra‐renal anomalies. Birth Defects Research 109:1204–1211, 2017. © 2017 Wiley Periodicals, Inc.
Extended Catalytic Scope of a Well‐Known Enzyme: Asymmetric Reduction of Iminium Substrates by Glucose Dehydrogenase
Authors: Roth Sebastian , Präg Andreas , Wechsler Cindy , Marolt Marija , Ferlaino Sascha , Lüdeke Steffen , Sandon Nicolas , Wetzl Dennis , Iding Hans , Wirz Beat , Müller Michael
Published: July 2017

NADP(H)‐dependent imine reductases (IREDs) are of interest in biocatalytic research due to their ability to generate chiral amines from imine/iminium substrates. In reaction protocols involving IREDs, glucose dehydrogenase (GDH) is generally used to regenerate the expensive cofactor NADPH by oxidation of d‐glucose to gluconolactone. We have characterized different IREDs with regard to reduction of a set of bicyclic iminium compounds and have utilized 1H NMR and GC analyses to determine degree of substrate conversion and product enantiomeric excess (ee). All IREDs reduced the tested iminium compounds to the corresponding chiral amines. Blank experiments without IREDs also showed substrate conversion, however, thus suggesting an iminium reductase activity of GDH. This unexpected observation was confirmed by additional experiments with GDHs of different origin. The reduction of C=N bonds with good levels of conversion (>50 %) and excellent enantioselectivity (up to >99 % ee) by GDH represents a promiscuous catalytic activity of this enzyme.