bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental-analytical approach to assessing mechanosensitive cartilage blood marker kinetics in healthy adults: dose-response relationship and interrelationship of nine candidate markers
Authors: Herger Simon , Vach Werner , Liphardt Anna-Maria , Nüesch Corina , Egloff Christian , Mündermann Annegret
Published: June 2021

Purpose: To determine the suitability of selected blood biomarkers of articular cartilage as mechanosensitive markers and to investigate the dose-response relationship between ambulatory load magnitude and marker kinetics in response to load. 

Methods: Serum samples were collected from 24 healthy volunteers before and at three time points after a 30-minute walking stress test performed on three test days. In each experimental session, one of three ambulatory loads was applied: 100% body weight (BW); 80%BW; 120%BW. Serum concentrations of COMP, MMP-3, MMP-9, ADAMTS-4, PRG-4, CPII, C2C and IL-6 were assessed using commercial enzyme-linked immunosorbent assays. A two-stage analytical approach was used to determine the suitability of a biomarker by testing the response to the stress test (criterion I) and the dose-response relationship between ambulatory load magnitude and biomarker kinetics (criterion II). 

Results. COMP, MMP-3 and IL-6 at all three time points after, MMP-9 at 30 and 60 minutes after, and ADAMTS-4 and CPII at immediately after the stress test showed an average response to load or an inter-individual variation in response to load of up to 25% of pre-test levels. The relation to load magnitude on average or an inter-individual variation in this relationship was up to 8% from load level to load level. There was a positive correlation for the slopes of the change-load relationship between COMP and MMP-3, and a negative correlation for the slopes between COMP, MMP-3 and IL-6 with MMP-9, and COMP with IL6. 

Conclusions: COMP, MMP-3, IL-6, MMP-9, and ADAMTS-4 warrant further investigation in the context of articular cartilage mechanosensitivity and its role in joint degeneration and OA. While COMP seems to be able to reflect a rapid response, MMP-3 seems to reflect a slightly longer lasting, but probably also more distinct response. MMP-3 showed also the strongest association with the magnitude of load.
Silencing of Carboxypeptidase E expression inhibits proliferation and invasion of Panc-1 pancreatic cancer cells
Authors: Lou Hong , Loh Y Peng
Published: June 2021

Background: Pancreatic cancer is one of the leading cause of cancer-related death globally. The molecular basis of this disease is complex and not fully understood. Previous studies have indicated that carboxypeptidase E (CPE) plays a role in promoting tumorigenesis in many cancer types. Here we have investigated the effect of carboxypeptidase E (CPE), including its isoform, in regulating the proliferation, migration and invasion of Panc-1 cells, a pancreatic cell line.

Methods: Panc-1 cells were transfected with CPE siRNA which targets both CPE-wild type and its isoform, or scrambled siRNA, for 24 h and then assayed for proliferation by the MTT and colony formation assays, and migration and invasion by wound healing and matrigel assays, respectively.

Results: CPE siRNA treatment of Panc-1 cells down-regulated the expression of CPE mRNA by 94.8%. Silencing of CPE mRNA expression resulted in a significant decrease in proliferation as revealed by the MTT assay and a 62.8% decrease in colony formation. Western blot analysis of expression of Cyclin D1 in Panc-1 cells treated with CPE siRNA showed a decrease of 32.5% compared to scr siRNA treated cells, indicating that CPE regulates proliferation through modulating this cell cycle protein.  Additionally, suppression of CPE expression in Panc-1 cells significantly decreased migration and invasion.

Conclusions: Our findings indicate that CPE may play an important role in regulating cell proliferation, migration and invasion to promote pancreatic cancer tumorigenesis.
От "словообразов" к "главокадрам": имажинистский монтаж Анатолия Мариенгрофа [From "word-images' to "chapter-shots": The imaginist montage of Anatolij Mariengof]
Authors: Huttunen Tomi
Published: June 2021

From "word-images' to "chapter-shots": The imaginist montage of Anatolij Mariengof. The article discusses the three dominant imaginist principles of Anatolij Mariengofs (1897-1962) poetic technique, as they are translated into prose in his first fictional novel Cynics (1928). These principles include the "catalogue of images", a genre introduced by Vadim Shershenevich, i.e. poetry formed of nouns, which Mariengof makes use of in his longer imaginist poems. Another dominant imaginist principle, to which Mariengof referred in his theoretic articles and poetic texts, is similar to the creating of shocking images typical of Russian futurism. Mariengofs application is the juxtaposition of "pure" (chistyj) and "impure" (nechistyj), either a conflict between the vehicle and the object within a metaphor or a conflict between metaphors. This is an essential poetic feature in both Mariengofs poetry and prose. The third, maybe the most Mariengofian imaginist principle, relevant to the study of Cynics, is the poetics of transition (poetika sdviga), i.e. a certain fragmented structure of the text, which is related to Mariengors use of heteroaccentual rhyme. All these principles can be treated as fundamental elements in Mariengofs use of montage technique in his fictional prose.
On the biological concept of subjective significance: A link between the semiotics of nature and the semiotics of culture
Authors: Wąsik Zdzisław
Published: June 2021

A logical-philosophical approach to the meaning-carriers or meaning-processes is juxtaposed with the anthropological-biological concepts of subjective significance uniting both for the semiotics of culture and the semiotics of nature. It is assumed that certain objects, which are identifiable in the universe of man and in the world surrounding all living organisms as significant from the perspective of meaning-receivers, meaning-creators and meaning-utilizers, can be determined as signs when they represent other objects, perform certain tasks or satisfy certain needs of subjects. Hence, the meaning of signifying objects may be found in the relation between the expression of a signifier and (1) a signified content, or (2) a signified function, or (3) a signified value of the cultural and natural objects subsumed by the interpreting subjects under the semiotic ones.
Vital signs: An ecosemiotic perspective on the human ecology of Amazonia
Authors: Hornborg Alf
Published: June 2021

Ecosemiotics represents a theoretical approach to human ecology that can be applied across several disciplines. lts primary justification lies inthe ambition to transcend "Cartesian", conceptual dichotomies such as culture/nature. society/nature, mental/material. etc. It argues that ecosystems areconstituted no less by flows of signs than by flows of matter and energy. This paper discusses the roles of different kinds of hmnan sign systems in the ecologyof Amazonia, ranging from the phenomenology of unconscious sensations. through linguistic signs such as metaphors and ethnobiological taxonomies, to money and the political economy of environmental destruction. Human-environmental relations mediated by direct, sensory and (oral) linguistic communication have tended to enhance biological diversity, suggesting modes of calibrating the long-term co-evolution of human and non-human populations. Economic sign systems, on the other hand, have rapidly and drastically transfonned human-environmental relations in Amazonia to the point where the entire rainforest ecosystem is illlder threat. In detaching themselves from the direct, "face-to-face" communication between humans and their natural environments, flows of money and commodities - and the decontextualized knowledge systems that they engender - have no means of staying geared to the long-term negotiation of local, ecological co-existence. It is argued that the ongoing deterioration of the biosphere can be viewed as a problem of communication, deserving semiotic analysis.
Семиотика культуры и феноменология страха (к постановке проблемы) [The semiotics of culture and the phenomenology of fear]
Authors: Lotman Mihhail
Published: June 2021

The semiotics of culture and the phenomenology of fear. In the paper fear is treated as semiotical phenomenon. The semiotical speciality of fear is that while being a strong semiotical factor, its semiotical nature is often overshadowed and fear is treated proceeding from the scheme of stimulus-reaction. In the paper fear is analysed in the context of both Peirce's semiotics and Saussure's semiology and it will be demonstrated that these approaches allow to open up different aspects of fear: while in Peircean perspective frightful evokes fear, then proceeding from the Saussure's approach we could say that fear creates the frightful, fear appears to be creative; we could even speak of fear as semiosis.
Habit formation as symmetry breaking in the early universe
Authors: Voetmann Christiansen Peder
Published: June 2021

This paper tries to combine Peirce’s cosmology and metaphysics with current understanding in physics of the evolution of the universe, regarded as an ongoing semiotic process in a living cosmos. While the basic property of Life is viewed as an unexplainable Firstness inherent in the initial iconic state of the vacuous continuum we shall consider and exemplify two sign developing processes: (a) the transition from icon to index is considered as a symmetry breaking emergence of order actualising one among the possibilities of the iconic vacuum; (b) the transition from index to symbol, regarded as a habit formation — an adaptation of the surroundings to the order that has emerged. While the iconic state is characterized by fractal self-similarity the transitions to index and symbol are modelled by the mean field theory of second order phase transitions.
Towards the semiotics of the observer
Authors: Grishakova Marina
Published: June 2021

The problem of the observer and point of view is examined within the broad semiological and cognitive perspective. Structuralist narratology made an attempt of a formal-linguistic classification of points of view to avoid anthropomorphic-visual connotations inherent in narratological terminology. The alternative opportunity would be the usage of terms-metaphors as theoretical models. From the point of view of the observer, the process of text generation evolves in the double space of perception/conception and interpretation. Instead of comparing different media in terms of the privileged metalanguage, it would be more fruitful to base the comparison upon their immanent cognitive characteristics.
The myth of the nation of poets and mass poetry in Lithuania
Authors: Satkauskytė Dalia
Published: June 2021

There are two problems discussed in the article. The first one is the phenomenon of mass literature and semiotic approach to it. According to Lotman, mass literature of the 20th (and 21st) centuries is not so much an object of semiotics as of sociology. However, it is possible to consider mass literature of earlier times as an object of semiotics of culture. Lotman discusses Russian mass literature of the 18th and 19th centuries as such an object in the article “Massovaya literatura kak istoriko-kulturnaya problema”. Considering mass literature a dynamic factor of the semiotic system, Lotman distinguishes its main features: a high degree of automatization and syndrome of retardedness. In the second part of the article the author discusses the phenomenon of mass poetry in contemporary Lithuania. This kind of mass literature is much more similar to the phenomenon discussed by Lotman than to the mass literature of the postmodernist epoch. Lithuanian mass poetry employs the codes of national romanticism (the end of 19th century) and considers itself an ignored part of high culture. This sort of poetry unknown to Western societies exhibits archaising tendencies in the modern postsoviet culture.
The problem of language and reality in Russian modernism: The conception of mirotvorchestvo in A. Remizov’s Rossiya v pis’menah
Authors: Aptekman Marina
Published: June 2021

Alexej Remizov is usually regarded by literary critics as a Symbolist rather than a Futurist writer. However, I would posit that Remizov similarly to the Futurists viewed language as “logos,” bozhestvennii glagol. According to the mystical interpretation of the famous words “At the beginning there was Word and the Word was with God and the Word was God”, when God was creating the world he named the objects, and these abstract names became a force for the appearance of an object in physical reality. In the light of these words, The Medieval mystical and magical philosophers claimed that one could restore the divine language of Creation, possess the ability to create objects anew, and thereby become Creator himself. One can argue that a major goal of Remizov was similar to that of his Medieval predecessors: to reveal the mystical power of language in order to create, not to describe reality. The paper analyzes three chapters from Alexej Remizov’s Rossiya v pis’menah, a book which can be read as a manifesto of Remizov’s attitude toward language and reality, and discuss possible sources that might have influenced Remizov in his attitude towards language.
An epigenetic machine
Authors: Markoš Anton , Gajdoš Eduard , Hajnal László , Cvrčková Fatima
Published: June 2021

Review: Marcello Barbieri, The Organic Codes: An Introduction to Semantic Biology
Структурные парадоксы русской литературы и поэтика псевдооборванного текста [Structural paradoxes of Russian literature and poetics of pseudobroken text]
Authors: Zaslavskii Oleg B.
Published: June 2021

Structural paradoxes of Russian literature and poetics of pseudobroken text. Traditionally, the Pushkin’s work “My provodili vecher na dache…” is considered to be uncompleted. However, on the basis of structural arguments, we show that, in fact, it is completed as an artistic whole. Taking also into account the results of previous analysis of works by Pushkin, Lermontov and Gogol’, we introduce a new notion of “pseudobroken texts”. Their distinctive feature consists in the structural correspondence between the break of a plot and a break as the theme of the text — such, that it is the break of a text which confirms that the text is finished. From the general viewpoint, such a paradoxical phenomenon can be viewed as modeling the impossibility to destroy art and culture.
Barthes’s positive theory of the author
Authors: Veivo Harri
Published: June 2021

While it is well known that Roland Barthes consecrated his last lecture series at the Collège de France to the theme of the preparation of a novel, it is less known that his first writings on literature focused on the same question, but from a less individual point of view. The interrogation that motivates Le Degré zéro de l’écriture (1953) and many of the essays in Essais critiques (1964) is the question of how to write, of what procedures one can follow in preparing a literary work of art. At the two ends of Barthes’s career one finds the same themes of writing as action and of the writer’s possibilities and motivations in writing. The article explores the hypothesis that there is ground for a positive theory of the author in Barthes’s work. It seeks to discover similarities between writings from the early and the late period that concern three themes: (1) writing as action, (2) the deferral of its achievement, and (3) writing as representation. The article ends with a discussion on the relationships between Barthes’s positive theory of the author and related important issues that have been discussed recently in literary criticism.
Specialization, semiosis, semiotics: the 33rd annual meeting of the Semiotic Society of America
Authors: Cobley Paul
Published: June 2021

Specialization, semiosis, semiotics: the 33rd annual meeting of the Semiotic Society of America
Max-plus convexity in Archimedean Riesz spaces
Authors: Horvath Charles
Published: June 2021

We study the topological properties of max-plus convex sets in an Archimedean Riesz space $E$ with respect to the topology and the max-plus structure associated to a given order unit $\boldsymbol u$; the definition of max-plus convex sets is algebraic and we do not assume that $E$ has an {\it a priori} given topological structure. To a given unit $\un$ one can associate two equivalent norms on $E$ one of which, denoted $\|\cdot\|_{\boldsymbol u}$, is classical, the other $\|\cdot\|_{\hun}$ is introduced here following a previous unpublished work of Stéphane Gaubert on the geodesic structure of finite dimensional max-plus; it is shown that the distance ${\sf D}_{\boldsymbol h\boldsymbol u}$ on $E$ associated to $\|\cdot\|_{\boldsymbol h\boldsymbol u}$ is a geodesic distance, called the Hilbert affine distance associated to $\boldsymbol u$, for which max-plus convex sets in $E$ are precisely the geodesically closed sets. Under suitable assumptions, we establish max-plus versions of some fixed points and continuous selection theorems that are well known for linear convex sets and we show that hyperspaces of compact max-plus convex sets are Absolute Retracts. We formulate a max-plus version of the Knaster-Kuratowski-Mazurkiewicz Lemma from which, following A. Granas and J. Dugundji, all of the consequences of the classical KKM Lemma can be derived in a max-plus version. P. de la Harpe showed that the interior of the standard simplex $\Delta_n$ equipped with the classical Hilbert metric-defined by the cross-ration of four appropriate points is isometric to a finite dimensional normed space. We give an explicit proof of that result: the norm space in question is $\mathbb R^n$ with the Hilbert affine norm $\|\cdot\|_{\boldsymbol h\boldsymbol u}$ with respect to $\boldsymbol u = (1, \ldots, 1)$.
Periodic solutions to reversible second order autonomous systems with commensurate delays
Authors: Balanov Zalman , Chen Fulai , Guo Jing , Krawcewicz Wiesław
Published: June 2021

Existence and spatio-temporal patterns of periodic solutions to second order reversible equivariant autonomous systems with commensurate delays are studied using the Brouwer $O(2) \times \Gamma \times \mathbb Z_2$-equivariant degree theory, where $O(2)$ is related to the reversing symmetry, $\Gamma$ reflects the symmetric character of the coupling in the corresponding network and $\mathbb Z_2$ is related to the oddness of the right-hand side. Abstract results are supported by a concrete example with $\Gamma = D_6$ - the dihedral group of order 12.
FILOSOFAR ACADÊMICO E PENSAMENTO INSURGENTE : (DIS-PENSANDO A FILOSOFIA A PARTIR DE OSWALD DE ANDRADE E RAUL SEIXAS)
Authors: Cabrera Julio
Published: June 2021

Dentro de uma série de convicções básicas do atual filosofar acadêmico destacam-se duas características: a exigência de exaustividade e a exigência de frieza vital, que determinam que os trabalhos filosóficos sejam feitos com pleno conhecimento de fontes e de maneira objetiva e impessoal. O texto traz à tona dois escritores brasileiros que contestam essas exigências: Oswald de Andrade enfrenta a exigência de exaustividade com a sua ideia da antropofagia, e Raul Seixas a exigência de frieza vital através de um pensamento vivido na música e assumido na própria vida e morte. O texto defende que estas duas atitudes enfrentam uma situação atual de indústria cultural filosófica, numa tecnologia do paper erudito e sem autoralidade. Pensar contra essa tendência é um modo de dispensar o pensamento europeu, visto hoje não como modelo a seguir, mas como mero objeto de estudo.
NEUTRALIZANDO O ARGUMENTO DA QUALIDADE: RESULTADOS PRELIMINARES DE UM ESTUDO DE FILOSOFIA EXPERIMENTAL
Authors: Seabra Murilo , Tolton Laura , Prendergast Luke
Published: June 2021

Esse artigo explora a hipótese da existência de preconceito de nacionalidade entre os membros da comunidade filosófica brasileira. Por utilizar um experimento para investigar o campo da filosofia, o estudo apresentado aqui pode ser classificado como um estudo de filosofia experimental. Entretanto, ele usa uma metodologia da psicologia cognitiva e tem como backgrounds teóricos as filosofias pós-coloniais e pós-modernas. Pós-graduandos e professores de sete departamentos de filosofia brasileiros avaliaram textos atribuídos a autores europeus e latino-americanos. A análise dos resultados revelou uma preferência pelo autor francês em detrimento do autor brasileiro; entretanto, os resultados foram inconclusivos quando outras nacionalidades latino-americanas foram contrastadas com nacionalidades europeias. Esse estudo indica que a comunidade brasileira de filosofia tende a criticar excessivamente os brasileiros que produzem filosofias próprias ao invés de se limitarem a comentar textos produzidos por autores europeus ou norte-americanos.
O OCIDENTE COMO PROBLEMA FILOSÓFICO
Authors: Sombra Laurenio Leite
Published: June 2021

Este artigo visa refletir sobre a prática de Filosofia na América Latina a partir da relação deste continente com a ideia de “Ocidente”. Para tanto, empreende uma reflexão filosófica sobre esta ideia, assim como sobre noções a ela correlacionadas, como modernidade e colonialidade. Apresenta, nesta perspectiva, a noção de “paradoxo da modernidade”, pelo poder que a modernidade tem de incluir-excluir sujeitos e valores. Ao pensar a filosofia na América Latina, reflete sobre a própria natureza do conceito de filosofia e as implicações dessa noção em relação a um pensar situado (ou à ausência desse pensar) na América Latina
PARA UNA AESTHESIS DESCOLONIAL DESDE EL PARADIGMA DE LA LIBERACIÓN EN LAS OBRAS DE ENRIQUE DUSSEL Y RODOLFO KUSCH
Authors: Ahumada Christian Soazo
Published: June 2021

El presente trabajo propone los fundamentos de una aesthesis descolonial desde el marco categorial provisto por la “exterioridad crítica” (Dussel) y el “estar-siendo” (Kusch) americanos frente al orden dominante de la totalidad moderno-occidental. Desde un universo de sensibilidad/afectividad configurado por la racionalidad vida-muerte (reproductiva) se plantea la importancia de la reproducción de la corporalidad viviente desde el campo económico y ritual/cultual para la generación del sentido cultural comunitario. A partir de este horizonte hermenéutico se comprende la significación de una nueva estética americana, obediencial, fundamentada desde las fuerzas vitales, mesiánicas, del espacio comunitario, con el fin de transformar la praxis social en un espacio de sensibilidad (aesthesis descolonial) orientado hacia una nueva constelación política de liberación.
Intelligent Malware - Trends and Possibilities
Authors: Plucar Jan , Frank Jiří , Walter Daniel , Zelinka Ivan
Published: June 2021

In recent months and years, with more and more computers and computer systems becoming the target of cyberattacks. These attacks are gaining strength and the sophistication of the approach in terms of how to attack. Attackers and Defenders are increasingly using artificial intelligence methods to maximize the success of their actions. For a successful defence, we must be able to anticipate future threats that may come. For these reasons, our research group is engaged in creating experimental software with artificial intelligence to test the possibilities and capabilities of such malware in the event of its deployment. This software has not only malware capabilities but also antimalware and can be used on both sides. This article introduces the reader to the main principles of our design, which can serve as a future platform for cyber defence systems.
Psychosocial meaning making in carceral spaces: a case study of prison and mental health care practice
Authors: Shepherd Andrew
Published: June 2021

Prisons represent sites of psychological distress and suffering. In this article, the implications of this, and the need for the maintenance of a psychosocial perspective, are explored. A psychogeographic overview of the prison environment is provided to consider the way it is constituted at different levels: the macro-social, meso-social and micro-social levels. Two vignettes are presented, which illustrate the process of loss and emergent self-destruction accompanying an enforced identity change followed by the radical means of stabilisation that may be adopted in opposition to this process. The essential nature of personal narrative construction – this process of sense making – is considered alongside the forcing impact of the social environment, as well as wider social pressures, and their impact on the dynamic process. In closing, a limitation of the employed methodology – focusing on individual experience – is remarked on: if these psychological processes take place through an act of modulation in response to a social field, how does the social field in turn respond to these modulations? In closing, I argue that through maintaining a psychosocial focus, researchers and clinicians discharge an ethical duty to maintain the attention of society on the suffering of some of its most vulnerable members.
Simulation and experimental research of a high-order Bragg grating
semiconductor laser
Authors: E Siyu , Zhou YinLi , Zhang Xing , Zhang Jianwei , Zeng Yugang , Cui Jinjiang , Liu Yun , Ning Yongqiang , Wang Lijun
Published: June 2021

In this paper, the influence of the epitaxial structure on distributed
Bragg reflector (DBR) grating characteristics is studied by simulation
analysis. Comparative analysis shows that the symmetrical epitaxial
structure can achieve a lower threshold current and, thus, a higher
power. Based on the simulated structure, a DBR laser based on a
symmetric epitaxial structure was fabricated, and a single
longitudinal mode laser output at

∼

1060

n
m

was obtained. The maximum power was
104.5 mW, and the side mode suppression ratio (SMSR) is 43 dB.
Si-substrate LEDs with multiple superlattice interlayers for beyond 24  Gbps visible light communication
Authors: Hu Fangchen , Chen Shouqing , Li Guoqiang , Zou Peng , Zhang Junwen , Hu Jian , Zhang Jianli , He Zhixue , Yu Shaohua , Jiang Fengyi , Chi Nan
Published: June 2021

High-speed visible light communication (VLC) using light-emitting diodes (LEDs) is a potential complementary technology for beyond-5G wireless communication networks. The speed of VLC systems significantly depends on the quality of LEDs, and thus various novel LEDs with enhanced VLC performance increasingly emerge. Among them, InGaN/GaN-based LEDs on a Si-substrate are a promising LED transmitter that has enabled VLC data rates beyond 10 Gbps. The optimization on the period number of superlattice interlayer (SL), which is a stress-relief epitaxial layer in a Si-substrate LED, has been demonstrated to be an effective method to improve Si-substrate LED’s luminescence properties. However, this method to improve LED’s VLC properties is barely investigated. Hence, we for the first time experimentally studied the impact of SL period number on VLC performance. Accordingly, we designed and fabricated an integrated 4 × 4 multichromatic Si-substrate wavelength-division-multiplexing LED array chip with optimal SL period number. This chip allows up to 24.25 Gbps/1.2 m VLC transmission using eight wavelengths, which is the highest VLC data rate for an InGaN/GaN LED-based VLC system to the best of our knowledge. Additionally, a record-breaking data rate of 2.02 Gbps over a 20-m VLC link is achieved using a blue Si-substrate LED with the optimal SL period number. These results validate the effectiveness of Si-substrate LEDs for both high-speed and long-distance VLC and pave the way for Si-substrate LED design specially for high-speed VLC applications.
A meta-analysis of cohort studies: Traumatic brain injury and risk of Alzheimer’s Disease
Authors: Zhang Jieyu , Zhang Yongkang , Zou Juntao , Cao Fei
Published: June 2021

Introduction

Recently, some epidemiological studies have reported that cognitive disorders in elderly people is accelerated with traumatic brain injury. But the causal relationship between traumatic brain injury and AD is still an area of controversy.

Aims

Our review was conducted to estimate the relation between traumatic brain injury and risk of AD.

Methods

All longitudinal population-based studies comparing incidence of AD between subjects with and without traumatic brain injury from their inception to September 2020 were searched in The Cochrane Library, PubMed, Medline, Embase, Web of Science without restriction of language. The meta-analysis was conducted using Stata software.

Results

A total of 17 studies involving 4289,548 individuals were included. After pooling these 17 studies, subjects with traumatic brain injury had significant higher incidence of AD than those without traumatic brain injury (RR: 1.17, 95% CI: 1.05–1.29). When considering the severity of traumatic brain injury, this elevated risk of AD was still significant comparing subjects with moderate and severe traumatic brain injury and those with no traumatic brain injury (RR: 1.30, 95% CI: 1.01–1.59).

Conclusion

Traumatic brain injury, especially moderate and severe traumatic brain injury may be associated with increased risk of AD.
Trans* media ecology: The emergence of gender variant selfies in print
Authors: Hatfield Joe E.
Published: June 2021

Despite having become more visible in popular and academic discourses over the last half decade, trans* selfies are not new. In this article, I examine an early set of trans* selfies featured in a sexploitation periodical published in the United States during the early 1960s. I show how numerous media, including bodies, clothing, cosmetics, photographs and magazines, produced a socio-technical environment through which trans* subjects composed alternative gender expressions and identities, formed intimate networks and created conditions of possibility for the eventual re-emergence of trans* selfies via digital social media platforms. Merging trans* theory with media ecology, I develop trans* media ecology as a conceptual frame from which to locate the always imbricated – but never complete – becoming of gendered bodies and media. Methodologically, trans* media ecology adopts three guiding principles: (1) genders are media, (2) genders depend on media and (3) genders and media change.
What do we value? The questions of Rachel Whiteread’s House
Authors: Huibregtse Elesa
Published: June 2021

On 25 October 1993, British artist Rachel Whiteread revealed her most ambitious sculptural work to date –House. The solidified space of this Victorian-era, terraced home physically existed for a mere 80 days; yet, during this time it became the subject of an intense media interest and heated public debate which reached the United Kingdom’s Houses of Parliament. WhileHousehas been discussed in depth within art historical scholarship for almost 30 years, trends in this academic body of work tend to focus on absence and memory in a highly contested public space, as well as thoughts on loss, death, architecture, the art market, politics and gentrification in London’s East End during the latter part of the twentieth century. What is lacking, however, is an examination ofHousewithin the larger context of visual culture and what it may, or may not, mean for contemporary viewers. Analysing the historical context of the work’s location through a Marxist lens, reveals the dehumanization which occurred within the East End’s class constructs throughout the nineteenth century, and its effect on housing policies well into the twentieth century. Reading the sculptural work itself, using the methodologies of semiotics, unveils mythologies regarding what is and is not expendable in our western spaces; particularly, the working class, houses and works of art in post-industrial capitalist societies. The ideologies embedded within these mythologies continue to appear in our mass media images to this day, leaving unanswered questions regarding what is truly valued in our societies. Thus, Whiteread’s unique work is an artistic intervention into an image-saturated environment, asking the viewers and readers of cultural texts to consider at what point in time we will seek to change how we treat that which has been arguably undervalued.
Közepes fejlettség, gazdasági szerkezet, termelékenység és az MKKV szektor = Middle level development, economic structure, productivity and the MSME sector
Authors: Csath Magdolna
Published: June 2021

A cikk elemzi a közepes fejlettségi csapda és a közepes jövedelmi csapda közötti különbségeket. Rávilágít a fejlettség humán és társadalmi mutatói és a növekedési mutatók közötti elméleti és gyakorlati eltérésekre. Foglalkozik továbbá a termelékenység mérésének ellentmondásaival, különös tekintettel a gazdasági szerkezet termelékenységet befolyásoló szerepére. Érvel végül az MKKV szektor és a családi vállalkozások, mint a teljes értéklánc kiépítésére képes olyan gazdasági szereplők fontossága mellett, amelyek kulcsszerepet játszhatnak a közepes fejlettségi csapda elkerülésében és egy fenntartható versenyképes fejlődési modell megvalósításában. = The article analyzes the differences between the middle income and middle development trap concepts. It hightlights the theoretical and practical differences between the human and social indicators of development, and the growth indicators. Furthermore it discusses the contradictions of measuring productivity, with special focus on the effects of economic structures on productivity. Finally it argues for the importance of the micro, small and medium sized enterprises (MKKV) and family businesses, which are able to develop a complete value chain, and by doing so they can serve as a key economic force for avoiding middle development trap, and for implementing a sustainable, competitive develop model.
Análise SWOT das políticas públicas para a universalização do saneamento em comunidades vulneráveis e a desigualdade de gênero, no município de Piracicaba/SP
Authors: Branco Filho Thelmo de Carvalho Teixeira , Almeida Amanda Francieli de , Felício Júlia Dedini , Moura Danieli Veleda Moura , Malheiros Tadeu Fabrício
Published: June 2021

Os serviços de saneamento devem ser articulados com as políticas públicas de desenvolvimento urbano e regional, de proteção ambiental, de promoção da saúde e outras de relevante interesse social, voltadas para a melhoria da qualidade de vida, para as quais o saneamento seja fator determinante. O planejamento traz transparência às decisões tomadas, sendo que tal processo se constitui em um instrumento de negociação entre as partes interessadas. Tendo em vista a importância dos instrumentos de planejamento para gerar as políticas públicas, o objetivo desta investigação é o de analisar como as políticas públicas de promoção e universalização do saneamento no município de Piracicaba-SP abrangem e se relacionam com as comunidades vulneráveis e as questões de gênero utilizando a matriz SWOT.
Políticas públicas
Authors: Araújo Airton
Published: June 2021

O artigo faz uma reflexão sobre a conceituação de políticas públicas e as ações afirmativas e da sua importância para a modernização dos novos Estados, assim como para a busca de justiça social e de reconhecimento daqueles povos historicamente discriminados numa sociedade. Assim sendo, procuras-se trabalhar neste artigo com a análise de que primeiro, no Brasil, as políticas públicas e afirmativas foram utilizadas pelas elites de poder, para acirrar as desigualdades raciais e o racismo, trazendo consequências até os dias atuais. Somente na década de noventa do final do século XX, é que o Estado brasileiro reconheceu o racismo e, a partir dos anos dois mil, políticas públicas mais efetivas que garantam melhores condições sociais aos negros e às negras começaram ser postas em prática.
Palavras-chave: burocracia; políticas públicas; ações afirmativas.
(IN)Acessibilidade versus políticas públicas
Authors: Borges Marcia Leite , Santos Carícia Hercilia A. Oliveira dos , Daier Racquel Nagem
Published: June 2021

Têm-se falado muito sobre políticas de inclusão das pessoas com deficiência na sociedade brasileira. Contudo, até que ponto as políticas públicas conseguem melhorar a qualidade de vida desses cidadãos? Esta é a questão principal deste artigo, que objetiva identificar a evolução das ações governamentais para a inclusão das pessoas com deficiência no Brasil. Nesse sentido, realizou-se a revisão bibliográfica dos principais autores que tratam sobre a questão da deficiência e informações governamentais sobre os investimentos no Programa Viver sem Limites, que deveria ser o “carro chefe” das ações de inclusão no Brasil. As políticas públicas, em especial as sociais, visam o bem-estar da população, tendo um papel fundamental na resolução das demandas das pessoas com deficiência, sendo instrumentos para o pleno exercício dos seus direitos e da busca de uma sociedade com equidade de oportunidades para todos os cidadãos. Por essa razão, elas devem estar conectadas à realidade e às necessidades destas pessoas. Contudo, o que tem sido consolidada é a omissão deste Estado quanto às estas questões, com a falta de priorização e com ações fragmentadas que o que fazem é contribuir para a reprodução e perpetuação da inacessibilidade da sociedade brasileira.
L’Art des Frères Quay à la Lumière du Grand Verre
Authors: O'Neill Eithne
Published: June 2021

L’art scénique raffiné des Frères Quay, en stop-motion et en live, est notoirement mystérieux. Par un évitement des codes du cinéma narratif, leur univers imaginaire, en grande partie fait main, résiste aux tentatives de le définir de manière univoque. À y regarder de plus près, leur monde révèle des éléments formels présents dans les stratégies adoptées par Duchamp pour sa sculpture en verre inachevée, nommée Le Grand Verre.  Dans quelle mesure ces œuvres d’art, cinétiques ou  statiques, ont-elles une histoire à raconter ? En tant que méthode d’investigation comparative, la question peut contribuer à éclaircir ce que c’est qu’un récit.
As micronarrativas imagéticas de Letícia Bertagna: oximoros verbovisuais e formas de vida
Authors: El-Jaick Ana Paula
Published: June 2021

A trajetória artística de Letícia Bertagna, uma das artistas indicadas da décima primeira edição do prestigiado Prêmio Pipa, é o disparador deste artigo. Aqui concentro-me na série de imagens digitais “Fundo do fora”, que vem sendo composta desde 2016 por Letícia. Dessa série, trago três imagens como gatilhos metonímicos para defender a hipótese de que Bertagna performa micronarrativas imagéticas, tendo como procedimento a operação de oximoros verbovisuais, sobretudo em aporias forjadas entre título e imagem. Lanço mão da perspectiva de linguagem do Wittgenstein maduro como pano de fundo teórico para a reflexão em que reconheço capacidades narrativa e poética nas obras de Bertagna a partir de variados recursos linguísticos. Além disso, vejo em seu gosto pelo cotidiano um movimento de deslocamento a revelar o estranho do comum. A estranheza comparece como oximoros verbovisuais em que a artista ficcionaliza vida e arte, diluindo seus limites e potencializando significâncias.
A arte dos Irmãos Quay à luz do Grande Vidro
Authors: Fonseca Fabio , O'Neill Eithne
Published: June 2021

A refinada arte cênica dos irmãos Quay, sendo ela em stop-motion ou ao vivo, é notoriamente misteriosa. Evitando os códigos do cinema narrativo, seu mundo imaginário, em grande parte feito à mão, resiste às tentativas de ser definido de maneira unívoca. Após um olhar mais atento, constata-se que o mundo dos irmãos Quay revela elementos formais presentes nas estratégias adotadas por Duchamp na realização do seu trabalho inacabado – O Grande Vidro. Em que medida é que estas obras de arte, cinéticas ou estáticas, têm uma história para contar? Esta questão, tendo como  método a análise comparativa, pode ajudar a esclarecer o que é uma narrativa.
Generación Go: un movimiento de construcción de ciudadanía global dinamizado por los jóvenes
Authors: Ortiz Vélez Mayte , Pérez Coutado Ariana
Published: June 2021

La Fundación SM —a partir de los estudios que ha realizado sobre la juventud en Iberoamérica— ha puesto en marcha un espacio de co-creación para formar a una nueva generación de jóvenes capaces de comprender los problemas globales y de actuar colaborativamente para solventarlos, con el fin de construir un mundo más inclusivo, justo y sostenible. Expertos educativos, profesores, equipos directivos de centros escolares y diferentes organizaciones dan el protagonismo a los jóvenes y reflexionan junto a ellos para diseñar un plan específico de formación en ciudadanía global en las escuelas de Iberoamérica.
El padre maestro Ignacio de Loyola
Authors: Fuentes Nuño Òscar
Published: June 2021

La tradición ignaciana forma parte de la corriente del Humanismo renacentista desde una visión católica a nivel pedagógico. En la base de su pensamiento educativo, encontramos el propio recorrido formativo de san Ignacio como discípulo, marcado por el método de París; así como la práctica educativa de las primeras instituciones educativas de la Compañía. Muchos de los principios educativos del santo vasco se recogen en la Parte IV de las Constituciones de la Compañía de Jesús.
Jaki korporatyzm w Polsce? Rada Dialogu Społecznego w okresie funkcjonowania rządu Beaty Szydło
Authors: Olejnik Maciej
Published: June 2021

Korporatyzm rozumiany jako system formułowania polityki, w ramach którego rząd, związki zawodowe i organizacje pracodawców wspólnie podejmują i implementują decyzje polityczne w obszarze społeczno-gospodarczym, występuje w wielu państwach Europy Zachodniej. Po 1989 roku w Polsce wykształciła się zdeformowana odmiana tego systemu – PR (Public Relations) korporatyzm. W jego ramach rząd pozoruje negocjacje trójstronne z partnerami społecznymi, aby zwiększyć poziom poparcia politycznego wśród obywateli. W rzeczywistości samodzielnie podejmuje decyzje polityczne.

Celem artykułu było zbadanie czy utworzenie nowego organu korporatystycznego (Rady Dialogu Społecznego), dysponującego znacząco większymi kompetencjami niż poprzednik (Trójstronna Komisja ds. Społeczno-Gospodarczych) doprowadziło do transformacji systemu uprawiania polityki w Polsce z PR korporatyzmu na korporatyzm zachodnioeuropejski.

W artykule poddano analizie porównawczej aktywność Rady w okresie funkcjonowania rządu Beaty Szydło (2015–2017) z działalnością Komisji w latach 2002–2015. Wyniki badań ujawniły, że Rada i Komisja były równie nieefektywnymi organami dialogu społecznego, na forum których nie były podejmowane istotne decyzje polityczne. W artykule wykazano, że zwiększenie uprawnień organu korporatystycznego nie musi powodować poprawy jakości dialogu społecznego. Po 2015 roku PR korporatyzm pozostał dominującym systemem formułowania polityki w Polsce.
Główne kierunki polityki wewnętrznej i zagranicznej Korei Północnej w latach 2019–2020
Authors: Bielicki Paweł
Published: June 2021

Przedmiotem mojego zainteresowania jest przedstawienie głównych kierunków polityki wewnętrznej i zagranicznej Korei Północnej w latach 2019 i 2020. Na wstępie zamierzam prześledzić przyczyny pogorszenia się relacji pomiędzy reżimem komunistycznym w Pjongjangu a Stanami Zjednoczonymi po nieudanym spotkaniu między przywódcą kraju azjatyckiego, Kim Dzong Unem a ówczesnym prezydentem USA Donaldem Trumpem w Hanoi w lutym 2019 r. W dalszej części rozważań moim zamierzeniem jest przeanalizowanie implikacji pandemii koronawirusa dla północnokoreańskiej dyplomacji oraz sytuacji ekonomicznej kraju. Ponadto dotykam kwestii zniknięcia Kima ze sceny w kwietniu 2020 r. i możliwych konsekwencji tego wydarzenia zarówno dla polityki wewnętrznej KRLD, ale także dla społeczności międzynarodowej. Dodatkowo prześledziłem możliwe implikacje wyboru Joe Bidena na prezydenta dla Stanów Zjednoczonych dla sytuacji w Korei Północnej. W podsumowaniu przedstawiłem prognozy na przyszłość, podejmując próbę odpowiedzi na pytanie, czy w dobie współczesnej sytuacji międzynarodowej należy spodziewać się znaczących zmian na Półwyspie Koreańskim. W swoich badaniach zastosowałem metodę analizy systemowej.
Epicureans and the City’s Laws
Authors: Diaco Sara
Published: June 2021

The article discusses the accusation advanced by Plutarch and Cicero, according to which the Epicureans are unjust, as they would break the law to pursue pleasure if certain of impunity, and deals with this criticism by analyzing the Epicurean theory of law and justice and comparing it with friendship. The article argues that, from a doctrinal standpoint, philia has a higher place in the Epicurean’s priorities and a stronger efficacy than positive law in serving the naturally just. It thus concludes that, as Plutarch and Cicero suspected, the Epicurean’s ultimate loyalty does not lie with positive law, in spite of its importance for social order, but rather with the naturally just (dikaion), better secured by friendship.
Justice, Power, and Participatory Socialism: on Piketty’s Capital and Ideology
Authors: O’Neill Martin
Published: June 2021

Thomas Piketty’s Capital and Ideology constitutes a landmark achievement in furthering our understanding of the history of inequality, and presents valuable proposals for constructing a future economic system that would allow us to transcend and move beyond contemporary forms of capitalism. This article discusses Piketty’s conceptions of ideology, property, and ‘inequality regimes’, and analyses his approach to social justice and its relation to the work of John Rawls. I examine how Piketty’s proposals for ‘participatory socialism’ would function not only to redistribute income and wealth, but also to disperse economic power within society, and I discuss the complementary roles of redistribution and predistribution in his proposals, and Piketty’s place in a tradition of egalitarian political economy associated with James Meade and Anthony Atkinson. Having elaborated on Piketty’s account of the relationship between economic policy and ideational change, and his important idea of the ‘desacralization’ of private property, I develop ‘seven theses’ on his proposals for participatory socialism, examining areas in which his approach could be enhanced or extended, so as to create a viable twenty-first century version of democratic socialism.
If Skill is Normative, Then Norms are Everywhere
Authors: Westra Evan , Andrews Kristin
Published: June 2021

Birch sketches out an ingenious account of how the psychology of social norms emerged from individual-level norms of skill. We suggest that these individual-level norms of skill are likely to be much more widespread than Birch suggests, extending deeper into the hominid lineage, across modern great ape species, all the way to distantly related creatures like honeybees. This suggests that there would have been multiple opportunities for social norms to emerge from skill norms in human prehistory.
Immunoregulatory function of Dictyophora echinovolvata spore polysaccharides in immunocompromised mice induced by cyclophosphamide
Authors: Lin Chenqiang , Zhang Hui , Chen Longjun , Fang Yu , Chen Jichen
Published: June 2021

The purpose of this study was to investigate whether the Dictyophora echinovolvata spore polysaccharides (DESP) affect the immunity in immunocompromised mice induced by cyclophosphamide (CTX). The healthy female Kunming mice were randomly divided into six groups, including a normal control (NC) group, a positive control group, a model control (MC) group, and three groups treated with low-, intermediate-, and high-dose polysaccharide, respectively. A series of immunoregulatory properties were determined, including humoral and cellular immunity, immune function, and immune factors of mononuclear macrophages. Compared with NC and MC groups, treatment with DESP significantly increased the spleen index and decreased the thymus index; increased the serum concentrations of immunoglobulin (Ig)A, IgG, IgM, hemolysin, IL-1β, and IL-2; delayed the allergic reaction; and improved the splenic lymphocyte transformation ability; and enhanced the phagocytosis of macrophages and the ability to secrete IL-6, TNF-α, caspase-1, and NO with DESP supplementation. These results indicated that DESP might have a good regulatory effect on CTX-induced immunodeficiency in mice, adjust the body’s immune imbalance, and improve the symptoms of low immunity.