bluuebunny/crossref_metadata_2025 huggingface dataset:
Research of Activity Pt-containing Zeolite Catalyst in Process of the Conversion of the Propane-Butane Mixture
Authors:   Saratov State University, Kuzmina R. I. , Frolov M. P. ,   Saratov State University, Vosmerikov A. V. ,   Institution of the Russian Academy of Sciences Institute of Petroleum Chemistry SB RAS, Yurkin N. A. ,   CJSC NPP "Chemical Technology Center"
Published: February 2024

Conversion of the propane-butane mixture at presence Pt-containing zeolite catalyst is researched at 300-500°C. It is shown that with increase in temperature of carrying out of process the yield of aromat­ic hydrocarbons, the maximum quality aromatics Ce-Ce increases reaches 40.0%wt at 500°C and a feed space velocity of raw materials 100 lr1. Conversion butanes thus reach is 94.0%.
Photoregulation of Seed Wheat Germination
Authors:   Saratov State University, Kasatkin M. Y. , Stepanov S. A. ,   Saratov State University, Prokhorova T. M. ,   Saratov State Agrarian University named after V.I. Vavilov
Published: February 2024

Based on literature review and own investigations a grow photoregu­ lation problem of wheat seedlings was analyzed. Was show, that some photoregulation systems of wheat embryo have tuned in certain level of light signal. Was proposed the important role of lightenviron­ ment in a period of seeds embryogenesis for wheat germination.
Using Syntetically Antyoxidants for Keeping Bacterium Vitality with Stress Abioethics Factors Activity
Authors:   Saratov State Medical University, Permyakova N. F. , Nechayeva O. V. ,   Saratov State Medical University, Kushnarenko A. N. ,   Saratov State University
Published: February 2024

The influence of syntetical compound with antioxidative activity on increaseing of vitality gram-positive and gram-negative microorgan­ isms under stressful action of antibiotical factors was shown.
Lifting Results for Finite Dimensions to the Transfinite in Systems of Varieties Using Ultraproducts
Authors: Sayed Ahmed Tarek
Published: February 2024

We redefine a system of varieties definable by a schema of equations to include finite dimensions. Then we present a technique using ultraproducts enabling one to lift results proved for every finite dimension to the transfinite. Let \(\bf Ord\) denote the class of all ordinals. Let \(\langle \mathbf{K}_{\alpha}: \alpha\in \bf Ord\rangle\) be a system of varieties definable by a schema. Given any ordinal \(\alpha\), we define an operator \(\mathsf{Nr}_{\alpha}\) that acts on \(\mathbf{K}_{\beta}\) for any \(\beta>\alpha\) giving an algebra in \(\mathbf{K}_{\alpha}\), as an abstraction of taking \(\alpha\)-neat reducts for cylindric algebras. We show that for any positive \(k\), and any infinite ordinal \(\alpha\) that \(\mathbf{S}\mathsf{Nr}_{\alpha}\mathbf{K}_{\alpha+k+1}\) cannot be axiomatized by a finite schema over \(\mathbf{S}\mathsf{Nr}_{\alpha}\mathbf{K}_{\alpha+k}\) given that the result is valid for all finite dimensions greater than some fixed finite ordinal. We apply our results to cylindric algebras and Halmos quasipolyadic algebras with equality. As an application to our algebraic result we obtain a strong incompleteness theorem (in the sense that validitities are not captured by finitary Hilbert style axiomatizations) for an algebraizable extension of \(L_{\omega,\omega}\).
Development and Evaluation of Recombinant NS3 Protein-based ELISA for the Detection of Bovine Viral Diarrhea Virus (BVDV) Antibodies
Authors: Arkanit S. , Lertwatcharasarakul P. , Thakur K.K. , Jala S. , Arunvipas P. , Yatbantoong N.
Published: February 2024

Background: Bovine Viral Diarrhea (BVD) is an important infectious disease that has a significant economic impact on dairy farms. Early detection of antibodies against BVD virus within herds can help reduce economic losses resulting from impaired animal health and reproductive performance. However, commercial ELISA tests tend to be expensive and unaffordable for smallholder farmers in Thailand. This study aims to develop an in- house indirect ELISA for the detection of antibodies to BVD. Methods: Gene synthesis and codon optimization were performed prior to protein expression. The prepared recombinant NS3 protein was confirmed through western blot analysis. Assay validation involved a comparison with an indirect commercial ELISA using a set of field serum samples (n=497) as references to evaluate its diagnostic accuracy. Measurements for test agreement and assay repeatability were calculated to assess performance. Result: The area under the receiver operating characteristic (ROC) curve was 0.86, indicating good discrimination between BVDV-positive and negative animals. The kappa coefficient, with an identified optimal cut-off value, was 0.577, indicated moderate agreement between the two tests. Additionally, the assay exhibited acceptable repeatability, with coefficients of variations (CVs) of 8.8% and 15.1% for intra-assay and inter-assay variations, respectively. This developed ELISA demonstrates both discriminatory ability and repeatability, making it a valuable alternative tool for the serodiagnosis of BVDV infection, especially in low-resource settings.
Veterans Administration Readjustment Counseling Service Counselors’ Training Needs: Results of a National Needs Assessment
Authors: Bryan Jennifer L. , Wittkower David , Walker Lisa , Ozanian Alfred , Fisher Michael , Asghar-Ali Ali A.
Published: February 2024

The Department of Veteran Affairs established Readjustment Counseling Service (RCS) to meet the mental health needs of active-duty service members, veterans, and their families. A diverse therapeutic skill set is needed to serve this complex population. To assess training needs, a national mixed-methods needs assessment consisting of a survey for RCS counselors and focus groups among counselors, RCS educational trainers, and national leadership was conducted. Survey results (n= 681) showed that RCS counselors were most interested in trainings on moral injury, acceptance and commitment therapy, and military sexual trauma (MST). Desired trainings aligned with populations served. Themes from focus groups revealed the need for foundational trainings so that all RCS counselors are adept in treating MST, moral injury, and posttraumatic disorder and proficient in caring for couples. Additionally, counselors desired advanced trainings tailored to individual counselors’ needs. RCS counselors identified multiple trainings to help them treat those they serve.
Lasem : Napak Tilas Perdagangan Opium Nusantara
Authors: Haikal Aditya Ikyan
Published: February 2024

Opium is a plant that is included in class 1 narcotics, this plant is a type of annual plant and cannot be cultivated in other areas except in the mountains of the subtropics. During the colonial era, the opium plants in the Dutch East Indies came from several regions, including India, Persia, Turkey and Singapore. In fact, during the Dutch

colonial era, opium was not the only imported commodity. Judging from the previous records it is stated that imported goods were transported during the Dutch East Indies colonial administration by using ships with the final route to ports in various regions, including cloth, oil, iron or other goods made from iron. , weapons, candles, liquor and various other items including opium. The opium trade in the Java region began to

spread since a binding agreement was obtained between King Amangkurat II and the Dutch, who at tha

t time was led by the VOC, to monopolize the opium trade to the Mataram territory which covered almost the entire island of Java at that time. From what was originally only the aristocratic class, over time it has turned into people of all groups becoming consumers of these goods. The Lasem people were no exception, they

were famous for distributing opium, even at that time in the black market trading model. They even earned the nickname as the "dark funnel" of Java as a form of their expertise in distributing these goods.
Umorzenie postępowania wykonawczego w sprawach o wykroczenia
Authors: Płońska Anna
Published: February 2024

Niniejszy artykuł porusza problematykę umorzenia postępowania wykonawczego w sprawach o wykroczenia. Ustawodawca w art. 15 § 1 k.k.w. określił katalog trzech ujemnych przesłanek postępowania wykonawczego, przy czym dwie z nich ujął wyraźnie: śmierć skazanego (ukaranego w postępowaniu w sprawach o wykroczenia) oraz przedawnienie wykonania kary. Trzecia przesłanka określona została w sposób nieostry jako inne przyczyny wyłączające to postępowanie. Opracowanie ma na celu analizę po- wyższych podstaw obligatoryjnego umorzenia postępowania wykonawczego z uwzględnieniem poglądów doktryny oraz judykatury.
THE INSTITUTIONAL ROLE IN FACILITATING THE ADVANCEMENT OF EQUATOR PARK TOURISM WITHIN THE VILLAGE OF JERUJU BESAR
Authors: Wulan dari Selvi Seri , Imtinan Aisyah Hilya , Rahmadanti Dhita , Listyaningrum Indah , Kurniawan Edi , Lestari Rosi
Published: February 2024

The research aims to determine the role of local institutions in the development of Equator Park tourism in Jeruju Besar Village, Sungai Kakap District.  The descriptive method is a useful option for describing, depicting and analyzing objects, conditions, and responses to an event that occurred in the Equator Park development. The results of this research are that Equator Park was built with the involvement of local institutions, namely POKDARWIS through role indicators at the preparatory stage. The imitating stage, Equator Park is inspired by Telok Standing Ecotourism which is on the Kupah River, this ecotourism also takes advantage of nature's preservation. Human Resources there use tickets for operational funds so that the rides there can be properly maintained. The last stage is the stage of accepting collective norms, with this stage the level of concern for villagers also increases
Great Minds Think Alike Entropy Artificial Intelligence and Knowledge Transfer
Authors: A Mageed Dr Ismail
Published: February 2024

An exposition of entropy applications to highlight some potential entropic applications to artificial intelligence and knowledge transfer. Entropy is a basic idea in artificial intelligence that is applied to many different tasks, such as reinforcement learning, data compression, and decision-making. By quantifying uncertainty and information content, it helps artificial intelligence models provide predictions and decisions that are well-informed. Therefore, this paper shines on spotlighting the significance of entropy to attract the attention of artificial intelligence research community to entropy as a powerful tool to advance artificial intelligence.The significance of knowledge transfer (KT), particularly intergenerational knowledge transfer (IGT), in knowledge management is also covered in this paper. To quantify the complexity of knowledge distribution inside an organisation and assess the efficacy of knowledge transfer (KT) initiatives, the notion of knowledge entropy (KE) is presented. Additionally, the KT model—which is based on the conceptions of tacitness and information content—is introduced. It combines personalisation and codification methodologies. Future research directions are offered alongside a few difficult open problems.
Investigating the Performance of Timex Intervals for Shoreline Edge Detection: A Sensitivity Analysis from a Low-Cost Coastal Monitoring System in Brandon Bay, Ireland
Authors: Nuyts Siegmund , Farrell Eugene , Nash Stephen , Fennell Sheena
Published: February 2024

Remote video imagery using shoreline edge detection is widely used in coastal monitoring in order to acquire measurements of nearshore and swash processes. Some of these systems have very limited flexibility due to their rigid structures and require considerable investment in hardware. As such, there is a need for an autonomous low-cost system (~€500) that can be rapidly deployed in the field, while still producing the outcomes required for coastal monitoring. This research presents a sensitivity analysis of time-lapse intervals for two low-cost cameras located in a remote coastal area, overlooking a dissipative beach-dune system. The analysis shows that RMSD in the detected shoreline is similar to other studies for intervals ranging between 1 second and 30 seconds (i.e., RMSDmax for Camera 1 = 2.8 m and Camera 2 = 1.3 m). The increase of the sampling interval from 1 s to 30 s is shown to have no significant adverse effect on the precision of shoreline detection. The research found that the limitations of battery life and memory storage substantially decrease when sampling intervals increase without an effect on the data quality. This also has a positive effect for low-cost systems and removes the requirement for external battery and memory storage. On the systems used, the battery life increased from ~10 days to ~100 days when the sampling interval was increased from 1 to 5 s., As such, the current standard of producing Timex images from 1 s sampling intervals over 10 minutes can be changed depending on the application and requirements needed for analysis.
Seroconversion and Kinetics of Vibriocidal Antibodies during the First 90 Days of Re-vaccination with Oral Cholera Vaccine in an Endemic Population
Authors: Chisenga Caroline Cleopatra , Phiri Bernard , Ngombe Harriet , Muchimba Mutinta , Musukuma Kalo , Silwamba Suwilanji , Laban Natasha Makabilo , Luchen Charlie , Liswaniso Fraser , Chibesa Kennedy , Mubanga Cynthia , Mwape Kapambwe , Simuyandi Michelo , Cunningham Adam F. , Sack David A , Bosomprah Samuel
Published: February 2024

Despite the successful introduction of oral cholera vaccines, Zambia continues to experience multiple, sporadic, and protracted cholera outbreaks in various parts of the country. While vaccines have been useful in staying the cholera outbreaks, the ideal window for re-vaccinating individual’s resident in cholera hotspot areas remains unclear. Using a prospective cohort study design, 225 individuals were enrolled, re-vaccinated with two doses of Shanchol™ regardless of previous vaccination and followed-up for 90 days. Bloods collected at baseline before re-vaccination, at day 14 prior to second dosing and subsequently on days 28, 60, and 90. Vibriocidal assay was performed on samples collected at all five time points. Our results showed that anti-LPS and vibriocidal antibody titers increased at day 14 after re-vaccination and decreased gradually at 28, 60 and 90 across all the groups. Seroconversion rates were generally comparable in all treatment arms. We therefore conclude that vibriocidal antibody titers generated in response to re-vaccination still wane quickly irrespective of previous vaccination status. However, despite the observed decline, the levels of vibriocidal antibodies remained elevated over baseline values across all groups, an important aspect for Zambia where there is no empirical evidence as to the ideal time for re-vaccination.
Exploring the Depths of Visual Understanding: A Comprehensive Review on Real-Time Object of Interest Detection Techniques
Authors: CHIDI EBERE UZOKA , UDANOR COLLINS N. , ANOLIEFO EDWARD
Published: February 2024

Object detection is complex and involved diverse requirements for different applications. In critical application such as visual impaired navigation guide and real-time surveillance for instance, identifying a particular object of instance is required and this involved a complex approach for realization. Literatures were reviewed, starting with the application of deep learning techniques for object detection; their gaps were identified and addressed using real-time object detection models literature review. From the review gaps were also detected and addressed using literature review on occlusion detection techniques. Object of instance detection in clustered scene with similar object of interest was identified as an open gap not addressed in the existing literature; even through it is vital for many applications. This research recommended an Occlusion Based Object of Instance Detection (OBOID) technique which used the spatial information to identify instant object of interest in clustered scene with many similarly object of interest. Limitation of the recommended OBOID is that it requires only system where position and distance of object is necessary to inform other decision.
Revisiting the use of the Gumbel distribution: A Frequency Analysis Perspective
Authors: Anghel Cristian-Gabriel , Ilinca Cornel
Published: February 2024

The manuscript presents the applicability of the Gumbel distribution in the frequency analysis of extreme events in hydrology. The advantages and disadvantages of using the distribution are highlighted, as well as recommendations regarding its proper use. A literature review was also carried out regarding the methods of estimating the parameters of the Gumbel distribution in hydrology. Thus, for the verification of the methods, case studies are presented regarding the determination of the maximum annual flows and precipitations using 9 methods of estimating the distribution parameters. The influence of the variability of the observed data lengths on the estimation of the statistical indicators, the estimation of the parameters and the quantiles corresponding to the field of small exceedance probabilities (p
Climate Change and Precautionary Policy: Insights from Small Prototype Models
Authors: Garrity Edward J.
Published: February 2024

Despite ample warning and significant lead time, global society has not acted sufficiently to combat climate change, and global carbon dioxide emissions are now about 60% higher today than in 1990 [1]. This paper uses marine fisheries as an analog model to compare with the many similar management issues faced with global climate change. Both marine fisheries and global climate change are complex systems that have similar properties that make management very difficult. A simple fishery prototype model is used to educate citizens about similar issues of dynamic complexity found in climate change models. We highlight how our slow reaction time to global climate change can be thought of as a mismatch between our cognitive abilities and the nature of global collective problems. Understanding the history and system structure of marine fisheries can provide insight into managing global climate change. We suggest ways to improve communication between science and citizens for updating mental models and changing climate policy.
Quantification and Influence by IL-1β of the Pain and Inflammatory Response after Placement of a Cement-Screw-Retained Restoration
Authors: Maza-Solano Serafín , Baus-Domínguez María , Gómez-Díaz Raquel , Ruiz-de-Leon-Pacheco Gonzalo , Torres-Lagares Daniel , Serrera-Figallo María-Angeles
Published: February 2024

The objective of this study was to evaluate the pain and inflammatory response in soft tissues using healing and prosthetic abutments of different diameters and lengths. Methods: The study population was rehabilitated with Astra tech EV single implants (Dentsply Sirona, Atlantis, Dentsply Sirona S.A., Barcelona, Spain), 4.2 and 4.8 millimetres in diameter in upper and lower maxilla and loaded with custom abutments digitally designed with the software of the company Dentsply Sirona (Atlantis WebOrder, Dentsply Sirona S.A., Barcelona, Spain), version 4.6.5, with a larger diameter than the healing abutment, to account for biomarkers through ELISA. Results: Rehabilitations in mandible and with healing abutments below 4.29 millimetres and rehabilitators below 2.18 millimetres elicited higher pain and inflammatory responses, and in turn higher interleukin 1β values. Conclusions: Greater inflammation was evident in cases in which healing abutments with reduced diameter were used in relation to the same subsequent rehabilitation with prosthetic abutments of larger diameter.
Quantum Hydrodynamics in External Magnetic Fields: From Nonrelativistic to Relativistic Regimes
Authors: Stephenson Matthew James
Published: February 2024

We explore nonrelativistic quantum electrodynamics in a background magnetic field, maintaining gauge invariance through a vector potential. The Lagrangian incorporates electron self-interactions and electromagnetic field interactions. The path integral formalism elucidates the effective action, focusing on the photon propagator and screening effects. Analyzing density and current components reveals Laurent expansions in the hydrodynamic limit. Equations of motion in real space are derived, including a discussion on Poiseuille-like flow and the Navier-Stokes equation. Nonrelativistic and relativistic hydrodynamics are discussed, with linearized equations presented. The study concludes with insights into the nonrelativistic limit, providing a comprehensive framework for quantum electrodynamics analysis.
Influence of Social Media Usage, Academic Performance and Working Memory among Undergraduate Students
Authors: Mgbedo Nnaemeka Emmanuel , Musa Marbyen Elma , Chhikara Pragati , Chaturvedi Rupam , Vyas Nikita , Zavradashvili Nana
Published: February 2024

Abstract: Social media has become a vital tool in ensuring productivity among Undergraduates, as studies have shown an increased number of users globally. This study assessed the impact of social media usage on undergraduates’ academic performance and working memory. Participants from three different universities such as the University of Georgia (UG), Eastern European University (EEU), and Batumi State University (BSU) completed this study using online google forms. UG and EEU are in the capital city, and BSU is in Batumi City. The study questionnaires were approved by the institutional review board before the data collection. Descriptive analyses were assessed for all study populations, characteristics, frequencies, percentages, means, and standard deviations using Statistical Package for Social Science (SPSS Inc., Chicago, IL, version 25.0 for Windows) software. 41.3% were male students, as most of the participants were foreign students living and studying in Georgia. Male students had the risk of ‘conflict’ with families and friends because of social media. Female students are at increased risk of using social media as an ‘escape’ from negative feelings. 89.7% of students that perform physical activities, considering their academic workload had the risk of preoccupation complaints. 87.9% felt dissatisfied regularly because they wanted to spend more time on social media. Utilization of social media differed based on the characteristics of the participants such as age, gender, and geography. We observed the increase in prevalence of social media addiction, its effect on academic performance and working memory among undergraduate students.
QUENCH: Quantum Unraveling in Enhanced Nonlinear CTP Hydrodynamics
Authors: Stephenson Matthew James
Published: February 2024

We embark on a systematic expansion of dissipative hydrodynamics through the utilization of a Schwinger-Keldysh FT. In this pursuit, we unveil the Navier-Stokes equations as a natural byproduct, emerging elegantly as an energy-momentum balance equation within our novel framework. The fluid system under scrutiny manifests intriguing invariance, showcasing symmetry notably characterized by spatial translation. Our methodology, rooted at the Closed-Time-Path (CTP) formalism, delves into the intricate landscape of hydrodynamic correlation functions and dissipative phenomena. A distinctive feature lies in the preservation of $\text{SDiff}_\pi(\mathbb{R}^{1,3})$ symmetry for fluctuation fields, enabling a systematic and rigorous treatment of dissipative hydrodynamics up to second order in derivatives. This approach significantly advances our comprehension of fluid behavior at low energy scales, offering fresh insights and expanding the horizons of theoretical exploration.
Beyond Psychotropic: Repurposing of Fluoxetine Toward Cancer Management and Its Molecular Mechanisms
Authors: Kadasah Sultan F. , Alqahtani Abdulaziz M. S. , Radwan Mohamed O.
Published: February 2024

Drug repurposing, rebranding an existing drug for a new therapeutic indication, is deemed a beneficial approach for a quick and cost-effective drug discovery process by skipping preclinical, Phase 1 trials and pharmacokinetic studies. Several psychotropic drugs including selective serotonin reuptake inhibitors (SSRIs) and tricyclic antide-pressants (TCAs) were studied for their potential application in different diseases es-pecially in cancer therapy. Fluoxetine (FLX) is one of the most prescribed psychotropic agents from SSRIs class for the treatment of several neuropsychiatric disorders with a favourable safety profile. FLX exhibited different oncolytic effects via mechanisms dis-tinct from its main serotonergic activity. Taking advantage of its ability to rapidly pen-etrate the blood-brain barrier, FLX could be particularly useful in brain tumors. This was proved by different in vitro and in vivo experiments using FLX as a monotherapy or combination with temozolomide (TMZ) or radiotherapy. In this review of literature, we summarize the potential pleiotropic oncolytic roles of FLX against different cancers highlighting the multifaceted activities of FLX and its ability to interrupt cancer prolif-eration via several molecular mechanisms and even surmount multidrug resistance (MDR). We elaborated on the successful synergistic combinations such as FXR/temozolomide and FXR/raloxifene for the treatment of glioblastoma and breast cancer, respectively. We showcased beneficial pharmaceutical trials to load FLX on car-riers to enhance its safety and efficacy on cancer cells. This is the first review article ex-tensively summarizing all previous FLX repurposing studies for the management of cancer.
Decolonizing Indigenous Drinking Water Challenges and Implications: Focusing on Indigenous Water Governance and Sovereignty
Authors: Hurlbert Margot , Acharibasam John Bosco , Datta Ranjan , Strongarm Sharon , Starblanket Ethel
Published: February 2024

Indigenous Peoples in Canada have shown great strength and resilience in maintaining their cultures and ways of life to date in the face of settler colonialism. Centering the water crises within Indigenous sovereignty and self-determination, we explore the impacts these crises are having on community members. Particularly, the continuous failure of the Canadian government to end the water crises in remote Indigenous communities, Star Blanket Cree Nation, is investigated in this paper. What implications have these water governance gaps had on Indigenous Peoples’ sovereignty and self-determination? We adopted an Indigenist theoretical framework to guide the study. Additionally, a community-based participatory research approach was adopted. To achieve our research goals of investigating the implications of the current water crises for Indigenous sovereignty and self-determination, specific methods of sharing circles were used to gather knowledge from community members, Elders, and knowledge keepers. The research findings strongly highlight the strength and resilience shown by remote Indigenous communities in the face of the current water crises and continuous government failure. Solving the current water crises will involve remote Indigenous communities taking charge of their own water governance through Indigenous-led water governance systems. Additionally, taking steps to rebuild trust through genuine reconciliation will be key. Therefore, listening to remote Indigenous communities and taking collaborative action is fundamental.
Water, Sanitation, and Hygiene (WASH) in Schools: A Catalyst for Upholding Human Rights to Water and Sanitation in Anápolis, Brazil
Authors: Pereira C. Tonelini , Sorlini Sabrina , Sátiro Josivaldo , Albuquerque Antonio
Published: February 2024

Ensuring access to water, sanitation, and hygiene (WASH) facilities, coupled with behavior change education in schools, is fundamental for fostering a conducive learning environment and promoting principles of inclusion, dignity, and equality. This study focuses on 12 primary schools in Anápolis, Brazil, encompassing 4,394 students and 248 teachers. WASH assessments were conducted through a questionnaire, observation of water and sanitation facilities and structures, and microbiological analysis. Over the period 2018 to 2020, the proportion of schools with safely managed drinking water surged from 42% to 92%. However, sanitation conditions in the schools were categorized as a basic level, with hygiene services rated as limited in 92% of the schools due to the absence of soap. While this study reveals that Anápolis schools generally align with WASH guidelines for basic/advanced drinking water services, there is a crucial need for enhancements in both hardware and software facilities to address sanitation and hygiene challenges.
Influence of individual genetic profile on the success of antibiotic usage
Authors:   Scientific Centre for Expert Evaluation of Medicinal Products, Moscow, Russian Federation, Kazakov R.E. , Chilova R.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Demchenkova E.Yu. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Pobedinskaya O.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Neofytou E.G. ,   Plekhanov Russian University of Economics, Moscow, Russian Federation, Lyandau Yu.V. ,   Plekhanov Russian University of Economics, Moscow, Russian Federation, Maslov S.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Davydov I.G. ,   M.E.Zhadkevich City Clinical Hospital, Moscow, Russian Federation, Bunyatyan N.D. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Zhuravleva M.V. ,   Scientific Centre for Expert Evaluation of Medicinal Products, Moscow, Russian Federation,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: February 2024

To date, numerous studies have reported significant associations of adverse drug reactions with genetic factors. In particular, the connection between drug-induced liver injury and carriage of certain MNS haplotypes when using amoxicillin and flucloxacillin has been demonstrated. The influence of polymorphisms of the PTPN22, ERAP2, PXR, ST6GAL1 genes was also observed. The pharmacokinetics of cephalosporins is affected by polymorphisms of drug transporter genes such as SLCO1A2, SLC22A8, ABCC2, ABCG2, ABCB1, which, however, requires further clarification. The pharmacokinetics of macrolides, according to some reports, may be related to the CYP3A4, SLCO1B1, ABCC2, and ABCB1 genes. The association of mutations in the mitochondrial DNA 12S rRNA genes in the development of non-syndromic and aminoglycoside-induced hearing loss has been well studied. The most important are the substitutions m.1095C>T, m.1494C>T and m.1555A>G. Risk factors for the development of neurological adverse reactions during the use of fluoroquinolones may be the carriage of alleles of blood-brain barrier transporters: ABCB1, ABCG2, SLCO1A2. Cutaneous adverse reactions with vancomycin may be associated with carrying MNS haplotypes, and urinary tract adverse reactions with the rs2789047 polymorphism. Daptomycin rarely contributes to the development of myopathy, which is presumably influenced by both renal functional status and the ABCB1 gene polymorphism. Key words: pharmacogenetics, genetic polymorphism, single nucleotide polymorphisms, antibiotics, adverse reactions
A comprehensive approach to data collection, management, and visualization for terrain characterization in cold regions
Authors: Baxter W. , Barker Amanda , Beal Samuel , Bosche Lauren , Busby Ryan , Courville Zoe , Deeb Elias , Doherty Stacey , Douglas Thomas , Gelvin Arthur , Jones Robert , Sullivan Taylor , Vas Dragos , Barbato Robyn
Published: February 2024

As global focus shifts to northern latitudes for their enhanced access to newly viable resources, US Army operational readiness in these extreme environments is increasingly important. Rapid and accurate intelligence on the conditions influencing operations in these regions is essential to mission success and warfighter safety. Arctic and boreal environments are highly heterogeneous, including changing extents of frozen versus thawing ground, snow, and ice that affect ground trafficability and visibility, terrain physics, and physicochemical properties of water and soil. Furthermore, projected climatic warming in these regions makes the timing of seasonal transitions increasingly uncertain. Broad coverage of long-term datasets is critical for assessing spatial and temporal variability in these northern environments at the landscape-scale. However, decadal measurements are difficult to acquire, manage, and visualize in the field setting. Here, we present a synopsis of data collection, management, and visualization for long-term permafrost, snow, vegetation, geophysics, and biogeochemical data from Alaska and review related literature. We also synthesize short-term data from various permafrost affected sites in the US and northern Europe to further assess the state of northern landscapes. Altogether, this work provides a comprehensive approach for high-latitude field site management to accurately inform mission-related operations in extreme northern environments.
Lesiones de mancha blanca asociadas al tratamiento de ortodoncia: una revisión de literatura
Authors:   , Consoli Senno Michella Vicenza
Published: February 2024

El objetivo de esta revisión de literatura es proporcionar evidencia científica sobre la formación de las lesiones de mancha blanca durante el tratamiento de ortodoncia, su incidencia, prevalencia, factores de riesgo relacionados con su desarrollo, progresión y regresión, además de explicar los métodos de diagnóstico más utilizados. Resultados: Se encontró que la incidencia de manchas blancas durante el tratamiento de ortodoncia varía ampliamente según el método de diagnóstico utilizado y el tiempo de tratamiento ortodóntico; sin embargo, no está relacionada a la edad ni sexo del paciente. La incidencia de lesiones de mancha blanca fue mayor en pacientes tratados con brackets convencionales, seguido de aquellos que usaron brackets de autoligado y fue menor en pacientes que usaron alineadores. Las piezas más afectadas son los incisivos laterales y caninos maxilares. Conclusiones: La incidencia de manchas blancas se asocia al tratamiento de ortodoncia, estando estrechamente relacionada a la técnica de tratamiento utilizada.
Determinación de valores de densidad urinaria, urea, creatinina y amonio en perros sin pelo del Perú mayores de 7 años en Lima entre los meses de mayo a julio del año 2018
Authors:   , De La Puente Del Aguila Cristina Simoni
Published: February 2024

El objetivo de este trabajo fue de determinar los valores de urea, creatinina, amonio y densidad urinaria en perros sin pelo del Perú (PSPP) mayor de 7 años en Lima. Con este fin se evaluaron 32 perros sin pelo del Perú, de los cuales las edades iban desde 7 años a 15 años, entre los meses de mayo a julio del 2018. Los valores de amonio, urea y creatinina se analizaron mediante la prueba de Kolmogorov – Smirnov (“K-S”) para 2 muestras, y la densidad urinaria mediante la prueba de T de Student para determinar el valor p. Los resultados muestran que los valores de amonio, urea, creatinina y densidad urinaria en promedio estuvieron dentro de lo normal. Se obtuvieron valores promedio de amonio 32.64 ± 20.62 ug/dl, urea de 42.36 ± 21.13 mg/dl , creatinina de 0.86 ± 0.36 mg/dl y de densidad urinaria de 1.024 ± 0.008 g/ml. Respecto a los valores referenciales de amonio urea y creatinina para la especie canina en comparación al grupo de perros entre 7 a 15 años de la raza peruana sin pelo se encontró diferencia estadística significativa (p<0.05); sin embargo, respecto a los valores referenciales de densidad urinaria y los encontrados en el grupo de estudio no se estableció diferencia estadística significativa (p>0.05).
Manejo de conflictos y el clima laboral de una empresa constructora, distrito de Surquillo (Lima - Perú), 2022
Authors:   , Allamanno Falen Berta Natalia , Torres Jimenez Jesus Socorro
Published: February 2024

En las últimas décadas las organizaciones han centrado sus esfuerzos en mejorar su clima laboral, en donde el recurso humano es necesario para fortalecer la cultura organizacional y con ello aumentar la productividad y mejorar la competitividad, así también los constantes cambios en el mercado generan problemas internos agudizándose aún más para las empresas sin experiencia, dejando con ello una variedad de conflictos por resolver dentro de la organización, siendo todo ello perjudicial para la producción de una empresa. Por consiguiente, se ha establecido como objetivo determinar la relación entre el manejo de conflictos y el clima laboral de una empresa constructora en la ciudad de Lima. Por ello se propuso elaborar una investigación de alcance correlacional, en donde se aplicó como instrumento de recolección de datos una encuesta de 18 ítems, la misma que se validó mediante un juicio de expertos y el coeficiente de Alfa de Cronbach, el estudio contó con una muestra de 50 colaboradores con experiencia para el manejo de conflictos internos, lo que genera constantes quejas y reclamos por parte de los trabajadores afectando al clima laboral, en ese sentido el liderazgo actual de la organización no ha logrado motivar a los colaboradores para ser más participativos al momento de abordar un conflicto, generando la desunión en los colaboradores debido a que cada uno de ellos intenta resolver los conflictos de la organización de manera individual y sin previa coordinación, se contó una nuestra de cincuenta colaboradores de una empresa constructora, en ese sentido se aplicó un coeficiente de Rho de Spearman el cual arrojo un resultado de 0,879, esto pudo determinar una correlación positiva entre ambas, con un nivel de significancia de (0,005), de este resultado se determinó que el manejo de conflictos que existe en la...
Implantación del programa Scratch para desarrollar un pensamiento computacional en estudiantes de 8 a 12 Años
Authors:   , Araujo Poclin Lourdes
Published: February 2024

Se realizó la implantación del Programa Scratch para desarrollar un pensamiento computacional en estudiantes de 8-12 años, debido a la necesidad en fortalecer el pensamiento computacional en niños, ello se demuestra en diferentes estudios que la programación scratch, mejora esta capacidad en niños, lo se demostró en el presente estudio. Investigación aplicada, cuantitativa y con diseño pre experimental con instrumento validado por expertos. Se trabajó con estudiantes (15). Los resultados nos muestran que la implementación Programa Scratch influyó en pensar de manera crítica y resolver problemas, se fundamentó mediante la prueba de rangos de Wilcoxon con sig<0.000, siendo significativa.
Producción de compost utilizando residuos orgánicos y estiércol de cerdo, con fines agrícolas en Casma, Ancash
Authors:   , Crisolo Berrospi Lisbeth Katherin
Published: February 2024

La calidad del compost se evaluó mediante una combinación de 4 tipos de residuos orgánicos (derivados de pescado, desechos orgánicos de mercado, aserrín y estiércol de cerdo), según el análisis de NPK. Las muestras fueron utilizadas en base a su contenido de relación C/N (25 % hasta 30 %). Se emplearon 4 tratamientos y 3 repeticiones, con un seguimiento semanalmente de los indicadores de temperatura, humedad y pH. En las muestras del compost final el resultado con mayor porcentaje para cada muestra fue: N (M4 = 1.27 %), Fosforo (M4 = 4.58 %), Potasio (M1 = 0.29 %), COO (M4 = 17.9 %), relación C/N (M3 = 16.1 %), pH (M1 = 6,91), humedad (M1 = 38.05 %), materia orgánica (M4 = 30.83 %), CIC (M1 = 28.4 meq/100g), los valores mencionados deben estar dentro de los parámetros establecidos por la Norma Técnica Colombiana (NTC) 5167 para considerar compost de calidad. La concentración de K es 0.75 % menor y la materia orgánica es 9 % mayor, de lo que establece la norma. El tratamiento del residuo de pescado con estiércol de cerdo permitió generar buen rendimiento en el contenido de sus nutrientes. La utilización de los residuos sólidos orgánicos es beneficioso debido a la alta concentración de nutrientes que puede ser aprovechado como fertilizante orgánico en la agricultura.
Logística de distribución y satisfacción de los clientes de una distribuidora avícola en Lima Sur, 2022
Authors:   , Rodriguez Flores Maryori Marcela , Quispe Osco Brayan Eugenio
Published: February 2024

La presente investigación “Logística de distribución y satisfacción de los clientes de una distribuidora avícola en Lima Sur, 2022” tuvo como objetivo general determinar la relación existente entre la logística de distribución con la satisfacción de los clientes de una distribuidora avícola en Lima Sur, 2022. Se aplicó el diseño no experimental transeccional correlacional-causal, con un enfoque cuantitativo; además, la población y muestra estuvieron compuestas por los administradores de cada pollería que la empresa distribuye, siendo un total de 35 clientes. Del estudio realizado se pudo concluir la relación existente entre las variables logística de distribución y satisfacción de los clientes; con una correlación de 0.391 y nivel de significancia P= 0.020 que permitió aceptar la hipótesis alterna y afirmar que existe una relación directa y significativa entre las variables estudiadas.
Evaluación de la eficacia del tratamiento con fluralaner oral en caninos naturalmente infestados con Rhipicephalus sanguineus en un albergue canino en Cieneguilla, Lima, Perú
Authors:   , Yep Lopez Sophie
Published: February 2024

El presente trabajo de investigación tuvo como objetivo evaluar la eficacia de fluralaner para el tratamiento y control de garrapatas en cuarenta y seis caninos infestados naturalmente con Rhipicephalus sanguineus. Los cánidos fueron agrupados en tres grupos experimentales: el Grupo A (n=30) fue tratado con fluralaner (FLU) (10-22 mg/kg) por vía oral cada 28 días por 56 días; al Grupo B (n=08) se le administró una formulación a base de sarolaner (SAR) (2-4 mg/kg) por vía oral cada 28 días por 56 días y al Grupo C (n=08) se le administró una tableta sin principio activo (CONTROL). Antes de aplicar el producto, se realizaron conteos de garrapatas 7 días previos y luego se efectuaron conteos a las 8 horas, 1, 2, 7, 14, 28, 42, 56, 70, 84 y 98 días después del tratamiento, siguiendo las indicaciones de AgroVet Market, según lo señalado por Yep et al. en 2022. La eficacia se evaluó en función del porcentaje de reducción del número de garrapatas. FLU demostró una eficacia superior al 86% desde las 8 horas después de la aplicación y alcanzó una reducción del 100% en el número de garrapatas en el día 28, manteniendo esta eficacia hasta el día 98. Se aplicaron las pruebas estadísticas de Kruskal-Wallis y rango con signo de Wilcoxon para comparar los resultados entre grupos, y las medidas post-tratamiento vs. las medidas basales, respectivamente. No se encontraron diferencias estadísticamente significativas en la eficacia entre FLU y SAR en ningún caso. Se puede concluir que el fluralaner, administrado a una dosis de 10-22 mg/kg cada 28 días, resulta altamente efectivo para controlar las infestaciones de garrapatas Rhipicephalus sanguineus en perros.
Abuso sexual infantil: Dinámicas traumatogénicas en mujeres sobrevivientes
Authors:   , Ucedo Quispe Roxana
Published: February 2024

El abuso sexual infantil (ASI) es un problema grave de nuestras sociedades, y que, según las estadísticas en el Perú, afecta a 1 de 5 mujeres, considerando que el conteo se refiere a aquellas personas que pudieron denunciarlo o reportarlo en alguna situación de búsqueda de reparación física o psicológica. Desde un enfoque cualitativo, se propuso explorar las manifestaciones conductuales del presente a causa de episodios de abuso sexual vivido en la niñez y/o adolescencia, en una muestra de 6 mujeres adultas que participaron voluntariamente. A través de una guía de entrevista semiestructurada, se pudo recoger sus relatos, los cuales giran alrededor de cómo han sobrellevado la condición de “sobrevivientes” frente a esos hechos traumáticos. Desde la teoría de las dinámicas traumatogénicas de Finkelhor y Browne, se confirmaron unas categorías (predefinidas) sobre los casos y se construyeron otras (emergentes) mediante la asistencia del software ATLAS.ti 23, que permitió diseñar redes conceptuales y vínculos entre las categorías, sustentadas con los testimonios. Las principales relaciones se establecieron entre las categorías de traición, conductas defensivas, desempoderamiento, sexualidad traumatizada y estigmatización. Se concluye que las dinámicas traumatogénicas en mujeres sobrevivientes es una constante a lo largo de su vida, lo que perjudica su salud mental, física y relacional. Proponemos trabajar sobre líneas de prevención en la escuela y la familia para identificar las conductas relacionados con la ASI, a fin de lograr un abordaje temprano, que no sea relegado a la etapa adulta, donde vivirá, además, estigmatización y revictimización.
WITHDRAWN: Frontotemporal Dementia: A systematic review
Authors: Khalifa Samar
Published: February 2024

The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
WITHDRAWN: Drama and Vocals Relation in Singing: a Comparative Study
Authors: Khalifa Samar
Published: February 2024

The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
The Initial COVID-19 Reliable Interactive DNA Methylation Markers and Biological Implications
Authors: Zhang Zhengjun
Published: February 2024

Earlier research has established the existence of reliable interactive genomic biomarkers. However, reliable DNA methylation biomarkers, not to mention interactiveness, have yet to be identified at the epigenetic level. This study, from 865,859 methylation sites, discovered two miniature sets of Infinium MethylationEPIC sites, each having eight CpG sites (genes) to interact with each other and disease subtypes. They led to nearly perfect (96.87-100% accuracy) prediction of COVID-19 patients from patients with other diseases or healthy controls. These CpG sites can jointly explain some post-COVID-19-related conditions. These CpG sites and the optimum performed genomic biomarkers reported in the literature rise to be potential druggable targets. Among these CpG sites, cg16785077 (gene MX1), cg25932713 (gene PARP9), and cg22930808 (gene PARP9) at DNA methylation levels indicate that the initial SARS-CoV-2 may be better treated as transcribed viral DNA into RNA virus, i.e., not as an RNA virus that has been concerned by scientists. Such a discovery can significantly change the scientific thinking and knowledge of viruses.
WITHDRAWN: Linking public perspectives on watershed issues to indicators, and natural regions as management units within a large watershed
Authors: Montemayor Marilou B.
Published: February 2024

The full text of this preprint has been withdrawn by the authors in order to comply with an institutional policy on preprints. Therefore, the authors do not wish this work to be cited as a reference.
WITHDRAWN: The bridge between the neurological and psychological visual response interpretations using Rorschach's test
Authors: Khalifa Samar
Published: February 2024

The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.