bluuebunny/crossref_metadata_2025 huggingface dataset:
Vesicular localization of the rat ATP-binding cassette half-transporter rAbcb6
Authors: Abdul Jalil Youssef , Ritz Vera , Jakimenko Ana , Schmitz-Salue Christoph , Siebert Heike , Awuah David , Kotthaus André , Kietzmann Thomas , Ziemann Christina , Hirsch-Ernst Karen I.
Published: December 2007

The clarification of subcellular localization represents an important basis toward characterization of ATP-binding cassette (ABC) transporters and resolution of their roles in cellular physiology. Rat Abcb6 (rAbcb6) is a membrane-situated half-transporter belonging to the ABC protein superfamily. To investigate rAbcb6 subcellular distribution, the human colon adenocarcinoma line LoVo, which we found to be devoid of endogenous human ABCB6 mRNA, was employed for heterologous expression of rAbcb6 bearing a COOH-terminal epitope tag (rAbcb6-V5). Following subcellular fractionation, rAbcb6-V5 was observed as an N-glycosylated protein in fractions enriched with lysosomal/endosomal membrane proteins. Indirect immunofluorescence analyses of rAbcb6-V5 using antibodies against a rAbcb6-specific peptide or against the V5-tag revealed a punctate pattern that was colocalized with lysosome-associated membrane protein 1 (LAMP1), a marker of lysosomes/late endosomes. Substantial colocalization of tagged rAbcb6 with lysosomal/late endosomal marker was confirmed with living, unfixed LoVo cells coexpressing rAbcb6 fused to enhanced green fluorescent protein. Vesicular distribution in LoVo cells was consistent with localization of endogenous rAbcb6 expressed in rat primary hepatocyte cultures or in liver sections, as revealed by overlap of rat Lamp1 with rAbcb6 in double immunofluorescence analyses. Since several Abcb6-related half-transporters confer heavy metal tolerance, we investigated whether rAbcb6 expression in LoVo cells might affect sensitivity toward transition metal toxicity. Applying MTT viability assays, we found that expression of either rAbcb6-V5 or untagged rAbcb6 conferred tolerance toward copper, but not to cobalt or zinc. In summary, these results demonstrate that rAbcb6 is a glycosylated protein targeted to intracellular vesicular membranes and suggest involvement of rAbcb6 in transition metal homeostasis.
Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48−/−Lepob/obmice devoid of ApoE or Ldlr
Authors: Lloyd David J. , McCormick Jocelyn , Helmering Joan , Kim Ki Won , Wang Minghan , Fordstrom Preston , Kaufman Stephen A. , Lindberg Richard A. , Véniant Murielle M.
Published: December 2007

The metabolic syndrome is a group of disorders including obesity, insulin resistance, atherogenic dyslipidemia, hyperglycemia, and hypertension. To date, few animal models have been described to recapitulate the phenotypes of the syndrome. In this study, we generated and characterized two lines of triple-knockout mice that are deficient in either apolipoprotein E (Apoe−/−) or low-density lipoprotein receptor (Ldlr−/−) and express no leptin (Lepob/ob) or apolipoprotein B-48 but exclusively apolipoprotein B-100 (Apob100/100). These two lines are referred to as Apoe triple-knockout-Apoe 3KO (Apoe−/−Apob100/100Lepob/ob) and Ldlr triple-knockout-Ldlr 3KO (Ldlr−/−Apob100/100Lepob/ob) mice. Both lines develop obesity, hyperinsulinemia, hyperlipidemia, hypertension, and atherosclerosis. However, only Apoe 3KO mice are hyperglycemic and glucose intolerant and are more obese than Ldlr 3KO mice. To evaluate the utility of these lines as pharmacological models, we treated both with leptin and found that leptin therapy ameliorated most metabolic derangements. Leptin was more effective in improving glucose tolerance in Ldlr 3KO than Apoe 3KO animals. The reduction of plasma cholesterol by leptin in Ldlr 3KO mice can be accounted for by its suppressive effect on food intake. However, in Apoe 3KO mice, leptin further reduced plasma cholesterol independently of its effect on food intake, and this improvement correlated with a smaller plaque lesion area. These effects suggest a direct role of leptin in modulating VLDL levels and, likewise, the lesion areas in VLDL-enriched animals. These two lines of mice represent new models with features of the metabolic syndrome and will be useful in testing therapies targeted for combating the human condition.
Neuroregulation of nonexercise activity thermogenesis and obesity resistance
Authors: Kotz Catherine M. , Teske Jennifer A. , Billington Charles J.
Published: December 2007

High levels of spontaneous physical activity in lean people and the nonexercise activity thermogenesis (NEAT) derived from that activity appear to protect lean people from obesity during caloric challenge, while obesity in humans is characterized by dramatically reduced spontaneous physical activity. We have similarly demonstrated that obesity-resistant rats have significantly greater spontaneous physical activity than obesity-prone rats, and that spontaneous physical activity predicts body weight gain. Although the energetic cost of activity varies between types of activity and may be regulated, individual level of spontaneous physical activity is important in determining propensity for obesity. We review the current status of knowledge about the brain mechanisms involved in controlling the level of spontaneous physical activity and the NEAT so generated. Focus is on potential neural mediators of spontaneous physical activity and NEAT, including orexin A (also known as hypocretin 1), agouti-related protein, ghrelin, and neuromedin U, in addition to brief mention of neuropeptide Y, corticotrophin releasing hormone, cholecystokinin, estrogen, leptin, and dopamine effects on spontaneous physical activity. We further review evidence that strain differences in orexin stimulation pathways for spontaneous physical activity and NEAT appear to track with the body weight phenotype, thus providing a potential mechanistic explanation for reduced activity and weight gain.
Characterization of mice lacking the gene for cholecystokinin
Authors: Lo Chun-Min , Samuelson Linda C. , Chambers James Brad , King Alexandra , Heiman Justin , Jandacek Ronald J. , Sakai Randall R. , Benoit Stephen C. , Raybould Helen E. , Woods Stephen C. , Tso Patrick
Published: December 2007

CCK acts peripherally as a satiating peptide released during meals in response to lipid feeding and centrally functions in the modulation of feeding, exploratory, and memory activities. The present study determined metabolic parameters, food intake, anxiety-like behaviors, and cognitive function in mice lacking the CCK gene. We studied intestinal fat absorption, body composition, and food intake of CCK knockout (CCK-KO) mice by using the noninvasive measurement of intestinal fat absorption along with quantitative magnetic resonance (QMR) imaging and the DietMax system, respectively. Additionally, exploratory and memory capacities were assessed by monitoring running wheel activity and conducting elevated plus-maze and Morris water-maze tests with these mice. Compared with wild-type (WT) littermate controls, CCK-KO mice had normal food intake, fat absorption, body weight, and body mass. CCK-KO mice ate more food than control animals during the light period and less food during the dark period. Energy expenditure was unchanged between the genotypes; however, CCK-KO mice displayed greater fatty acid oxidation. CCK-KO mice were as active as WT animals in the running wheel test. CCK-KO mice spent more time in the closed arms of an elevated plus-maze, indicative of increased anxiety. Additionally, CCK-KO mice exhibited attenuated performance in a passive avoidance task and impaired spatial memory in the Morris water maze test. We conclude that CCK is involved in metabolic rate and is important for memory and exploration. CCK is intimately involved in multiple processes related to cognitive function and food intake regulation.
Effects of targeted Bcl-2 expression in mitochondria or endoplasmic reticulum on renal tubular cell apoptosis
Authors: Bhatt Kirti , Feng Leping , Pabla Navjotsingh , Liu Kebin , Smith Sylvia , Dong Zheng
Published: December 2007

Bcl-2 family proteins are central regulators of apoptosis. As the prototypic member, Bcl-2 protects various types of cells against apoptotic insults. In mammalian cells, Bcl-2 has a dual subcellular localization, in mitochondria and endoplasmic reticulum (ER). The respective roles played by mitochondrial and ER-localized Bcl-2 in apoptotic inhibition are unclear. Using Bcl-2 constructs for targeted subcellular expression, we have now determined the contributions of mitochondrial and ER-localized Bcl-2 to the antiapoptotic effects of Bcl-2 in renal tubular cells. Wild-type Bcl-2, when expressed in renal proximal tubular cells, showed partial colocalizations with both cytochrome c and disulfide isomerase, indicating dual localizations of Bcl-2 in mitochondria and ER. In contrast, Bcl-2 constructs with mitochondria-targeting or ER-targeting sequences led to relatively restricted Bcl-2 expression in mitochondria and ER, respectively. Expression of wild-type and mitochondrial Bcl-2 showed significant inhibitory effects on tubular cell apoptosis that was induced by cisplatin or ATP depletion; however, ER-Bcl-2 was much less effective. During ATP depletion, cytochrome c was released from mitochondria into the cytosol. This release was suppressed by wild-type and mitochondrial Bcl-2, but not by ER-Bcl-2. Consistently, wild-type and mitochondrial Bcl-2, but not ER-Bcl-2, blocked Bax activation during ATP depletion, a critical event for mitochondrial outer membrane permeabilization and cytochrome c release. In contrast, ER-Bcl-2 protected against apoptosis during tunicamycin-induced ER stress. Collectively, the results suggest that the cytoprotective effects of Bcl-2 in different renal injury models are largely determined by its subcellular localizations.
Arterial stiffness and interdialytic weight gain influence ambulatory blood pressure patterns in hemodialysis patients
Authors: Agarwal Rajiv , Light Robert P.
Published: December 2007

Besides an overall increase in blood pressure, hemodialysis patients have marked disturbance in interdialytic ambulatory blood pressure pattern that is characterized by blunted circadian amplitude and a steady rise in blood pressure between dialysis treatments. The pathophysiology of this abnormal blood pressure profile is poorly understood. We hypothesized that the circadian amplitude, the interdialytic increase (linear trend), and the average level of blood pressure (the intercept) are related to the extent of arterial stiffening and the degree of accumulation of salt and water between dialysis treatments. Using a generalized cosinor model, we simultaneously compared the impact of interdialytic weight gain and echo-Doppler-measured aortic pulse wave velocity on the mean level of blood pressure, linear changes over the interdialytic interval, and oscillatory changes in blood pressure. In a cross-sectional analysis of 11,833 blood pressure measurements from 125 long-term hemodialysis patients, we found that aortic pulse wave velocity and interdialytic weight gain had a substantial impact on interdialytic ambulatory blood pressure level, trends, and rhythms. Arterial stiffness was associated with an overall increase in the level (intercept) of systolic, diastolic, and pulse pressure. Interdialytic weight gain, on the other hand, was associated with interdialytic increase (linear trend) in blood pressure. The circadian amplitude was blunted by increments in either arterial stiffness or interdialytic weight gain. Since patterns of ambulatory arterial blood pressure are related to cardiovascular risk factors such as interdialytic weight gain and increased arterial stiffness, the pattern of ambulatory blood pressure recordings may also be of prognostic significance in hemodialysis patients.
The Oscillation Score: An Efficient Method for Estimating Oscillation Strength in Neuronal Activity
Authors: Mureşan Raul C. , Jurjuţ Ovidiu F. , Moca Vasile V. , Singer Wolf , Nikolić Danko
Published: December 2007

We present a method that estimates the strength of neuronal oscillations at the cellular level, relying on autocorrelation histograms computed on spike trains. The method delivers a number, termed oscillation score, that estimates the degree to which a neuron is oscillating in a given frequency band. Moreover, it can also reliably identify the oscillation frequency and strength in the given band, independently of the oscillation in other frequency bands, and thus it can handle superimposed oscillations on multiple scales ( theta, alpha, beta, gamma, etc.). The method is relatively simple and fast. It can cope with a low number of spikes, converging exponentially fast with the number of spikes, to a stable estimation of the oscillation strength. It thus lends itself to the analysis of spike-sorted single-unit activity from electrophysiological recordings. We show that the method performs well on experimental data recorded from cat visual cortex and also compares favorably to other methods. In addition, we provide a measure, termed confidence score, that determines the stability of the oscillation score estimate over trials.
Do Corticomotoneuronal Cells Predict Target Muscle EMG Activity?
Authors: Griffin D. M. , Hudson H. M. , Belhaj-Saïf A. , McKiernan B. J. , Cheney P. D.
Published: December 2007

Data from two rhesus macaques were used to investigate the pattern of cortical cell activation during reach-to-grasp movements in relation to the corresponding activation pattern of the cell's facilitated target muscles. The presence of postspike facilitation (PSpF) in spike-triggered averages (SpTAs) of electromyographic (EMG) activity was used to identify cortical neurons with excitatory synaptic linkages with motoneurons. EMG activity from 22 to 24 muscles of the forelimb was recorded together with the activity of M1 cortical neurons. The extent of covariation was characterized by 1) identifying the task segment containing the cell and target muscle activity peaks, 2) quantifying the timing and overlap between corticomotoneuronal (CM) cell and EMG peaks, and 3) applying Pearson correlation analysis to plots of CM cell firing rate versus EMG activity of the cell's facilitated muscles. At least one firing rate peak, for nearly all (95%) CM cells tested, matched a corresponding peak in the EMG activity of the cell's target muscles. Although some individual CM cells had very strong correlations with target muscles, overall, substantial disparities were common. We also investigated correlations for ensembles of CM cells sharing the same target muscle. The ensemble population activity of even a small number of CM cells influencing the same target muscle produced a relatively good match ( r ≥ 0.8) to target muscle EMG activity. Our results provide evidence in support of the notion that corticomotoneuronal output from primary motor cortex encodes movement in a framework of muscle-based parameters, specifically muscle-activation patterns as reflected in EMG activity.
Tonotopic Control of Auditory Thalamus Frequency Tuning by Reticular Thalamic Neurons
Authors: Cotillon-Williams Nathalie , Huetz Chloé , Hennevin Elizabeth , Edeline Jean-Marc
Published: December 2007

GABAergic cells of the thalamic reticular nucleus (TRN) can potentially exert strong control over transmission of information through thalamus to the cerebral cortex. Anatomical studies have shown that the reticulo-thalamic connections are spatially organized in the visual, somatosensory, and auditory systems. However, the issue of how inhibitory input from TRN controls the functional properties of thalamic relay cells and whether this control follows topographic rules remains largely unknown. Here we assessed the consequences of increasing or decreasing the activity of small ensembles of TRN neurons on the receptive field properties of medial geniculate (MG) neurons. For each MG cell, the frequency tuning curve and the rate-level function were tested before, during, and after microiontophoretic applications of GABA, or of glutamate, in the auditory sector of the TRN. For 66 MG cells tested during potent pharmacological control of TRN activity, group data did not reveal any significant effects. However, for a population of 20/66 cells (all but 1 recorded in the ventral, tonotopic, division), the breadth of tuning, the frequency selectivity and the acoustic threshold were significantly modified in the directions expected from removing, or reinforcing, a dominant inhibitory input onto MG cells. Such effects occurred only when the distance between the characteristic frequency of the recorded ventral MG cell and that of the TRN cells at the ejection site was <0.25 octaves; they never occurred for larger distances. This relationship indicates that the functional interactions between TRN cells and ventral MG cells rely on precise topographic connections.
Morphology, Intrinsic Membrane Properties, and Rotation-Evoked Responses of Trochlear Motoneurons in the Turtle
Authors: Jones Michael S. , Ariel Michael
Published: December 2007

Intrinsic properties and rotation-evoked responses of trochlear motoneurons were investigated in the turtle using an in vitro preparation consisting of the brain stem with attached temporal bones that retain functional semicircular canals. Motoneurons were divided into two classes based on intrinsic properties. The first class exhibited higher impedance (123.0 ± 11.0 MΩ), wider spikes (0.99 ± 0.05 ms), a single spike afterhyperpolarization (AHP), little or no spike frequency adaptation (SFA), and anomalous rectification, characterized by an initial “sag” in membrane potential in response to hyperpolarizing current injection. The second class exhibited lower impedance (21.8 ± 2.5 MΩ), narrower spikes (0.74 ± 0.03 ms), a double AHP, substantial SFA, and little or no rectification. Vestibular responses were evoked by horizontal sinusoidal rotation (1/12-1/3 Hz; peak velocity: 30–100°/s). Spiking in higher-impedance cells was recruited earlier in the response and exhibited a more limited dynamic range relative to that of lower impedance cells. Spiking evoked by injecting depolarizing current during rotation was blocked during contraversive motion and was consistent with a shunting inhibition. No morphological features were identified in neurobiotin-filled cells that correlated with the two physiological classes. Recovered motoneurons were multipolar but exhibited a less-complex dendritic morphology than ocular motoneurons of similarly sized mammals. The two physiologically defined cell classes have homologues in other vertebrates, suggesting that intrinsic membrane properties play an important role in oculomotor processing.
Reflections and Commentary From the Field: Connecting the Reform of Administrator Preparation to the Reform of Teacher Preparation
Authors: Monk David H.
Published: December 2007

Purpose: Attention is drawn in this article to the presence and dysfunctional nature of a disconnection between professional preparation programs for administrators and for teachers.

Findings: A case is made for achieving greater alignment between the work going on in these areas, particularly in light of the growing efforts to hold schools accountable for pupil performance gains. A case is also made for balancing reform efforts so that disproportionate attention is not paid to one area relative to the other.
“Living on Barbed Wire”: Resilient Women Administrators in Educational Leadership Programs
Authors: Christman Dana , McClellan Rhonda
Published: December 2007

Background: Despite access for women administrators in educational leadership departments, the longevity of their service within them is tenuous. Women administrators are caught in the social constructions of gender and leadership.

Purpose: To explore how some women administrators in educational leadership programs have sustained their administrative roles; to evaluate whether their resiliency rests on a feminine type of leadership.

Participants: A group of seven diverse women administrators in educational leadership programs who were peer nominated, are accomplished scholars, and have an average of 11.25 years of experience.

Research Design: A computer-based qualitative Delphi technique using an online asynchronous mode and ensuring anonymity.

Data Collection and Analysis: Several iterations focused on the identification of resiliency markers and components, descriptions of episodes denoting the participants' overcoming difficult situations, proposals for adapting educational leadership programs to foster better women leaders, and the reflection and interpretation of data.

Findings: The participants' rankings and narratives indicate that gender identity and leadership are more complex than to simply fit them into one gender construction model or another. When interacting in particular episodes, resilient women leaders embrace or disclaim one gender norm for another to varying degrees. A multidimensional-gendered leadership model is provided.

Conclusions: Faculty and students should not expect the socially constructed norms in women leaders. These resilient participants suggest that gendered leadership norms are too simplistic and that women leaders must be willing to shift into multidimensional gender and traverse conventional borders.
Do GED Recipients Differ From Graduates and School Dropouts?
Authors: Ou Suh-Ruu
Published: December 2007

The differences in income, crime, health, mental health, and substance use among high school dropouts, GED recipients, and high school graduates are investigated. The study sample is drawn from the Chicago Longitudinal Study (CLS), an ongoing investigation of a panel of low-income minority children who grew up in the inner city. After controlling for sociodemographic factors, early cognitive skills, and participation in postsecondary education, results indicate that there are significant differences between dropouts and GED recipients, and between GED recipients and high school graduates in the five aspects of quarterly income equal to or above average, life satisfaction, future optimism, symptoms of severe depression, and substance use.
Developing Teachers for High-Poverty Schools
Authors: McKinney Sueanne E. , Haberman Martin , Stafford-Johnson Delia , Robinson Jack
Published: December 2007

This investigation sought to determine if there was a difference in the development of effective urban teacher characteristics after completing a traditional internship experience or a Professional Development School internship experience. The Urban Teacher Selection Interview was used to assess 10 characteristics including persistence, value of children's learning, putting ideas into practice, approach to at-risk students, professional/personal orientation to students, the bureaucracy, fallibility, teacher success, student success, and planning and organization. Assessments were completed before and after subjects participated in urban internships. Pre- and posttest scores were compared using descriptive statistics and a paired-samples t test. Results communicated no significant difference between pre- and posttest scores when student interns completed a traditional or Professional Development School internship experience. This suggests that although the internship experience is often viewed as the capstone experience of teacher preparation programs, short-term experiences do not adequately prepare teacher candidates for urban school teaching.
Popular White Teachers of Latina/o Kids
Authors: Marx Sherry
Published: December 2007

This article presents a year-long qualitative study conducted in an “urban” high school, where 77% of the students were Latina/o and 100% of the teachers were White. A teacher in the school, the author studied four popular teachers for the (a) ways they could relate to students, (b) ways they could not relate, and (c) influences of teachers' Whiteness on relating. Findings show that teachers could relate to students through personal experiences but not through race or culture. Most teachers held exceedingly deficit views about the students' home lives, cultures, and families. Implications for the education of Latina/o schoolchildren are discussed.
Punishing Hubris: The Perils of Overestimating One's Status in a Group
Authors: Anderson Cameron , Ames Daniel R. , Gosling Samuel D.
Published: December 2007

Individuals engage in status self-enhancement when they form an overly positive perception of their status in a group. We argue that status self-enhancement incurs social costs and, therefore, most individuals perceive their status accurately. In contrast, theories of positive illusions suggest status self-enhancement is beneficial for the individual and that most individuals overestimate their status. We found supportive evidence for our hypotheses in a social relations analysis of laboratory groups, an experiment that manipulated status self-enhancement, and a study of real-world groups. Individuals who engaged in status self-enhancement were liked less by others and paid less for their work. Moreover, individuals tended to perceive their status highly accurately. Mediation analyses showed that status self-enhancers were socially punished because they were seen as disruptive to group processes.
Advantaged Group's Emotional Reactions to Intergroup Inequality: The Dynamics of Pride, Guilt, and Sympathy
Authors: Harth Nicole Syringa , Kessler Thomas , Leach Colin Wayne
Published: December 2007

Three studies establish intergroup inequality to investigate how it is emotionally experienced by the advantaged. Studies 1 and 2 examine psychology students' emotional experience of their unequal job situation with worse-off pedagogy students. When inequality is ingroup focused and legitimate, participants experience more pride. However, when inequality is ingroup focused and illegitimate, participants experience more guilt. Sympathy is increased when inequality is outgroup focused and illegitimate. These emotions have particular effects on behavioral tendencies. In Study 2 group-based pride predicts greater ingroup favoritism in a resource distribution task, whereas group-based sympathy predicts less ingroup favoritism. Study 3 replicates these findings in the context of students' willingness to let young immigrants take part in a university sport. Pride predicts less willingness to let immigrants take part whereas sympathy predicts greater willingness. Guilt is a weak predictor of behavioral tendencies in all studies. This shows the specificity of emotions experienced about intergroup inequality.
When Being a Model Minority Is Good . . . and Bad: Realistic Threat Explains Negativity Toward Asian Americans
Authors: Maddux William W. , Galinsky Adam D. , Cuddy Amy J. C. , Polifroni Mark
Published: December 2007

The current research explores the hypothesis that realistic threat is one psychological mechanism that can explain how individuals can hold positive stereotypical beliefs toward Asian Americans yet also express negative attitudes and emotions toward them. Study 1 demonstrates that in a realistic threat context, attitudes and emotions toward an anonymous group described by only positive, “model minority” attributes are significantly more negative than when the group was described using other positive attributes. Study 2 demonstrates that realistic threat significantly mediates the relationship between (a) the endorsement of the both the positive and negative stereotypes of Asian Americans and (b) subsequent negative attitudes and emotions toward them. Studies 3 and 4 conceptually replicate this effect in experimental situations involving interactions with Asian Americans in realistic threat contexts. Implications for understanding the nature of stereotyping and prejudice toward Asian Americans and other minority groups are discussed.
Longitudinal Investigation of Reciprocal Relationship Between Stress Reactions and Hardiness
Authors: Vogt Dawne S. , Rizvi Shireen L. , Shipherd Jillian C. , Resick Patricia A.
Published: December 2007

Although many studies have examined hardiness as a protective factor against stress reactions, to the authors' knowledge no studies have yet examined the impact of stress reactions on hardiness. However, there is theoretical support for this notion. In this longitudinal study of 1,571 Marine recruits who participated in a highly stressful training program, the authors applied regression-based cross-lagged analyses to examine associations between stress reactions and hardiness over time for both men and women, and they investigated social support as a moderator of these relationships. Men who were hardier at Time 1 (T1) reported lower stress reactions at Time 2 (T2), and men who experienced more stress reactions at T1 were less hardy at T2. Although the negative impact of stress reactions on hardiness was strongest when social support was low for both genders, stress reactions predicted enhanced hardiness when social support was high for women only.
Genes, Personality, and Attachment in Adults: A Multivariate Behavioral Genetic Analysis
Authors: Donnellan M. Brent , Burt S. Alexandra , Levendosky Alytia A. , Klump Kelly L.
Published: December 2007

Behavioral genetic methods were used to estimate genetic and environmental contributions to (a) attachment-related anxiety and avoidance and (b) the overlap between these attachment dimensions and the Big Five personality traits. Two major findings emerged from these analyses. First, individual differences in attachment-related anxiety and avoidance were heritable, and second, much of the overlap between adult attachment and the Big Five traits was due to shared genetic influences. Discussion focuses on the implications of these results for attachment theory and research and provides a speculative account of the interplay between temperamental dimensions and internal working models of relationships across the life span.
A Mile in Moccasins: How Situational Experience Diminishes Dispositionism in Social Inference
Authors: Balcetis Emily , Dunning David A.
Published: December 2007

In four studies, this article investigates the impact of situational experience on social inference. Participants without firsthand experience of a situation made more extreme and erroneous inferences about the personalities of people behaving in that situation than did participants with firsthand experience. Firsthand experience, thus, appears to diminish dispositionism in social inference because it informs people about the situational constraints that guide behavior. Across all studies, participants also displayed holier-than-thou biases, overpredicting how generously they would act relative to predictions about their peers and also relative to how they actually acted when the situation came.
Sociocultural Influences on Body Image Concerns of Young Chinese Males
Authors: Jackson Todd , Hong Chen
Published: December 2007

This research assessed the extent to which sociocultural factors implicated in explanations of weight dissatisfaction among young Western females extend to sources of body image concern in emerging adult and adolescent males from the People's Republic of China. In Study 1, 219 Mainland Chinese male university students completed measures of stature concern, fatness concern, sociocultural influence (i.e., appearance-based social pressure, teasing, and comparison), and demographics. Social pressure and teasing made unique contributions to fatness concern among participants. Physical stature concerns were also predicted by social pressure and comparison, independent of reported height and fatness concerns. In Study 2, findings were largely replicated in late adolescent ( n = 299) and early adolescent ( n = 265) boys. Together, findings supported the hypothesis that appearance pressure, teasing, and comparison may be salient influences on a range of body image concerns within diverse adolescent and young adult samples.
Enhancement of Muscle Activity by Electrical Stimulation in Cerebral Palsy: A Case—Control Study
Authors: Katz Amir , Tirosh Emanuel , Marmur Rachel , Mizrahi Joseph
Published: December 2007

The objectives of this study were to compare the effects of low-intensity electrical stimulation of the quadriceps muscle in children with cerebral palsy in the following 2 modes: reconditioning by long-term training of the muscle versus real-time assist to the muscle during motion. To evaluate the force enhancement in the assist mode, we developed a method to dissociate the volitional and the induced components from the total electromyographic signal. The study group, including 5 children with cerebral palsy (mean age, 3.3 years; 0.4 SD), underwent 2 testing sessions: 1 before and 1 after 3-month training by electrical stimulation. Each session included 2 series of trials: 1 with electrical stimulation, as an orthotic assist, and 1 without electrical stimulation. The tests included flexion—extension movements of the knee at a self-selected pace. The results showed that, compared to before training, there was a significant increase in the average motion velocity and a decrease in motion jerk and in knee torque after training in both the electrical stimulation— assisted and —unassisted modes. Of special interest was the significant decrease in quadriceps—hamstrings cocontraction following training by electrical stimulation but not during electrical stimulation—assisted motion. The results obtained for the group with cerebral palsy were statistically different from those of the control group, but this difference decreased after long-term training by electrical stimulation. It was concluded that, in children with cerebral palsy, electrical stimulation is more beneficial in long-term training than when used as a real-time motion assist. Although muscle strength is not affected, more centrally controlled attributes such as cocontraction are improved.
A Pilot Study on Cord Blood Levels of Erythropoietin and Its Relationship to Periventricular Leukomalacia in Preterm Infants
Authors: Okumura Akihisa , Kidokoro Hiroyuki , Kato Toru , Kubota Tetsuo , Hayakawa Fumio , Kuno Kuniyoshi , Watanabe Kazuyoshi
Published: December 2007

This article reports the results of a study on the relationship between cord blood levels of erythropoietin and periventricular leukomalacia. Cord blood was obtained from 19 infants with gestational age between 27 and 32 weeks. Cystic periventricular leukomalacia was seen in 4 of them. Erythropoietin levels were not different between those with and those without periventricular leukomalacia.
Epidemiological Study of Autism Spectrum Disorder in China
Authors: Wong Virginia C. N. , Hui Stella L. H.
Published: December 2007

The object of this study was to investigate the epidemiologic pattern of autism spectrum disorder in Chinese children. An autism spectrum disorder registry has been established in Hong Kong since 1986 by collecting data in a single center (the only university-affiliated child assessment center in Hong Kong). Since 1997, inpatient data from all public hospitals under the Hospital Authority have been stored in a central computerized program and retrieved from the Clinical Data Analysis and Reporting System. Clinical data have also been retrieved through the Clinical Data Analysis and Reporting System to ensure the completion of the registry, and these suspected cases have undergone the same diagnostic evaluation for autism spectrum disorder, as some of the new autism cases might be hospitalized in the public hospital. The incidence and prevalence of autism spectrum disorder have been calculated for the period of 1986 to 2005 using the population statistics available in the government for children less than 15 years old in Hong Kong. This study has included 4 247 206 person-years from 1986 to 2005 for children less than 15 years old and 1 174 322 person-years for those less than 5 years old in Hong Kong. Altogether, 645 children 0 to 4 years old with diagnoses of autism spectrum disorder were identified from 1986 to 2005. The estimated incidence of autism spectrum disorder was 5.49 per 10 000. The prevalence was 16.1 per 10 000 for children less than 15 years old for the same period. The male to female ratio was 6.58:1. This is the first reported epidemiologic study of autism spectrum disorder in Chinese children. The incidence rate is similar to those reported in Australia and North America and is lower than Europeans.
Predictive Value of Sequential Electroencephalogram (EEG) in Neonates With Seizures and Its Relation to Neurological Outcome
Authors: Khan Richard Lester , Lahorgue Nunes Magda , Garcias da Silva Luis Fernando , da Costa Jaderson Costa
Published: December 2007

The aim of this study was to evaluate the relationship of sequential neonatal electroencephalography (EEG) and neurological outcome in neonates with seizures to identify polysomnographic features predictive of outcome. Sequential EEGs recordings of 58 neonates that belonged to 2 historical cohorts of newborns with seizures from the same neonatal intensive care unit and who had follow-up at the Neurodevelopment Clinic of the Hospital São Lucas, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) in Porto Alegre, Brazil, were analyzed and classified into 4 groups: normal-normal, abnormal-normal, abnormal-abnormal, normal-abnormal. In patients with more than 2 recordings, during the neonatal period, the first EEG was compared with the following more abnormal. A total of 58 pairs of 2 sequential EEGs were analyzed. Considering the first EEG, a statistically significant difference was observed between the relationship of the result of this exam, if it was abnormal, with developmental delay ( P = .030) and postnatal death ( P = .030). Abnormal background activity was also related to neurodevelopment delay ( P = .041). EEG sequences abnormal-abnormal and normal-abnormal significantly correlated to the outcome epilepsy ( P = .015). Abnormal sequential background activity was associated with neurodevelopment delay ( P = .006) and epilepsy ( P = .041). The burst suppression pattern when present in any EEG correlated with epilepsy ( P = .013) and postnatal death ( P = .034). Sequential abnormal background patterns in the first and second EEG increased the risk for epilepsy (relative risk [RR] = 1.8; 95% confidence interval [CI] = 1.03-3.0) and neurodevelopment delay (RR = 2.20; 95% CI = 1.3-3.0). Abnormal background activity only in the second electroencephalogram increased the risk for neurodevelopment delay (RR = 2.20; 95% CI = 1.3-3.0). All the neonates (n = 33) with seizures related to probable hypoxic ischemic encephalopathy had abnormalities in the first EEG ( P = .030). Postnatal epilepsy was diagnosed in 24 infants (41.4%). Five (20.8%) presented West syndrome, 7 (29.2%) focal symptomatic epilepsy, 6 (25%) generalized symptomatic epilepsy, 2 (8.3%) early myoclonic encephalopathy, 1 (4.2%) early infantile epileptic encephalopathy, and in 3, the epileptic syndrome was undefined (12.5%). All infants (n = 5) with West syndrome had some degree of neurodevelopment delay. In conclusion, our findings suggest that sequential EEG in neonates with seizures has more predictive value to estimate the outcomes of neurodevelopment delay, epilepsy, and postnatal death than a single EEG recording. The abnormal background activity in even 1 EEG of the sequential recordings was more significant to determine neurological outcome than abnormal ictal activity or abnormalities in the organization of sleep state.
A Quantitative Magnetic Resonance Imaging Analysis of the Cerebellar Deficit Hypothesis of Dyslexia
Authors: Kibby Michelle Y. , Fancher Jill B. , Markanen Rochelle , Hynd George W.
Published: December 2007

Recent evidence suggests that the primary source of dysfunction in dyslexia is the cerebellum. To examine the cerebellar deficit hypothesis of dyslexia, 20 children with dyslexia and 20 children without dyslexia were assessed using neuropsychological testing and quantitative magnetic resonance imaging. Results demonstrated that the volumes of both hemispheres and the vermis were not statistically significantly different between groups. However, children without dyslexia demonstrated greater rightward cerebellar hemisphere asymmetry. The relationship between cerebellar morphologic structure and phonological processing was assessed. For children without dyslexia, bilateral hemisphere volume moderately correlated with phonological awareness and phonological short-term memory. Hemisphere asymmetry moderately correlated with rapid naming errors, and the anterior vermis volume moderately correlated with phonological awareness. For children with dyslexia, the only statistically significant correlation was between rapid naming errors and the left hemisphere volume. Evidence suggests that atypical cerebellar morphologic structure may have a role in dyslexia for a subgroup of individuals. Although children with and without attention-deficit/hyperactivity disorder did not differ in cerebellar morphologic structure, the anterior vermis volume moderately correlated with inattention, hyperactivity, and impulsivity, while the right hemisphere volume moderately correlated with inattention and hyperactivity. Our findings provide mixed support for the cerebellar deficit hypothesis of dyslexia. Although cerebellar morphologic structure is atypical in some individuals with dyslexia, it is inconsistently related to cognitive or motor dysfunction. In our sample, cerebellar morphologic structure may be related to about one-third of cases of dyslexia. Hence, dyslexia may be best accounted for by a combination of cortical and cerebellar contributions.
Hemorrhagic Shock and Encephalopathy Syndrome: Clinical Course and Neurological Outcome
Authors: Gefen Roni , Eshel Gideon , Abu-Kishk Ibrahim , Lahat Eli , Youngster Ilan , Rosenbloom Ehud , Kozer Eran
Published: December 2007

The syndrome of hemorrhagic shock and encephalopathy is associated with an acute onset of diarrhea, followed by shock, disseminated intravascular coagulopathy, multiorgan failure, and encephalopathy. The etiology of this syndrome is unknown, and despite intensive treatment, the outcome is often fatal or associated with severe neurological sequelae. Two infants aged 6 and 9 months were admitted with this syndrome within a 24-hour time interval. The authors hereby present the clinical course and a prospective evaluation of the neurological outcome. A review of the literature regarding this infrequent syndrome is presented.
The Production of the “Battered Immigrant” in Public Policy and Domestic Violence Advocacy
Authors: Bhuyan Rupaleem
Published: December 2007

In the context of U.S. public policy, battered immigrant signifies a person who is eligible to adjust his or her status under immigration law if he or she can demonstrate they have suffered domestic violence in the United States perpetrated by a U.S. citizen or legal permanent resident. Among community organizers, the term battered immigrant signifies a broader range of people for whom legal immigration status plays a role in their options for safety planning and/or leaving an abuser, the potential threat of deportation, and the eligibility for public benefits. Based on an ethnographic study of domestic violence advocacy with South Asian immigrants in Seattle and around the United States, this article examines how the difference in signification has direct social and political consequences with regard to who may access the benefits and protection offered to victims of domestic violence in the United States.
Does Using Nonnumerical Terms to Describe Risk Aid Violence Risk Communication?
Authors: Zoe Hilton N. , Carter Angela M. , Harris Grant T. , Sharpe Amilynn J. B.
Published: December 2007

Actuarial risk assessments yield valid numerical information about violence risk, but research suggests that forensic clinicians prefer to communicate risk using nonnumerical information (i.e., verbal terms such as high risk). In an experimental questionnaire study, 60 forensic clinicians disagreed on the interpretation of nonnumerical terms, and their nonnumerical risk estimates for one group of violent offenders were influenced by comparison with another group. Adding nonnumerical terms to numerical probability statements had no effect on hypothetical forensic decisions. These findings suggest that nonnumerical descriptive terms do not aid effective communication of violence risk and that contextual information might artificially affect estimated risk.
Violent Men
Authors: Edin Kerstin E. , Lalos Ann , Högberg Ulf , Dahlgren Lars
Published: December 2007

This article deals with discourses of intimate partner violence and is based on interviews with professionals who meet violent men. The professionals emphasized the importance of men taking unreserved responsibility for their violent behavior. Intimate partner violence was viewed not only as “power and control” but as the result of complex situations and interplays. The discourses presented an ambivalent explanation of violent men as both ordinary and deviant. They were understood as having a strained background, but to be rather ordinary, often functioning well at work and in society. Yet, they have nonstandard views of women, act deviant in their communication and interplay with others, and cannot cope with certain situations in intimate relationships. Based on the interviews, men inclined to partner violence may be generalized as those who: attack immediately, explode unexpectedly, or ultimately become aggressive. The discussion challenges unreflected discourses as means for change when counteracting violence.
Predictors of Child Molestation
Authors: Wood Eric , Riggs Shelley
Published: December 2007

A conceptual model derived from attachment theory was tested by examining adult attachment style, cognitive distortions, and both general and victim empathy in a sample of 61 paroled child molesters and 51 community controls. Results of logistic multiple regression showed that attachment anxiety, cognitive distortions, high general empathy but low victim empathy significantly increased the odds of child molester status. Findings supported theoretically based hypotheses, suggesting that attachment theory may be useful in the conceptualization and treatment of child molesters.
Abortion as Crime Control
Authors: Chamlin Mitchell B. , Myer Andrew J. , Sanders Beth A. , Cochran John K.
Published: December 2007

Donohue and Levitt have applied the selective incapacitation hypothesis to account for what they contend is a latent function of the Supreme Court's 1973 decision in Roe v. Wade to legalize abortion—the decline in the crime rate during the 1990s. They contend that abortion, insofar as it removes recidivists from the population before they are born, has the compositional effect of lowering the overall rate of crime within the country. In this article, their thesis is indirectly evaluated by estimating interrupted time series models of the impact of the Roe decision on several nativity time series for two categories of women Donohue and Levitt identify as being disproportionately at risk for giving birth to high-rate offenders. None of the ARIMA transfer function models lends any credence to Donohue and Levitt's perspective.
Systems Modeling for Drug Courts
Authors: Gilbertson Troy A.
Published: December 2007

This policy research note argues for a systems modeling approach to explain drug court processes. The conceptual model links participants' beliefs, behavioral intentions, and behavioral outcomes. Conceptualization of core constructs combines elements of planned behavior theory with those of routine activities theory and acknowledges the transtheoretical model and therapeutic jurisprudence. Systems modeling is offered in an effort to identify specific drug court interventions that work, more accurately select suitable offenders, and ultimately to promote public safety.