bluuebunny/crossref_metadata_2025 huggingface dataset:
A importância dos índices antropométricos na prevenção de risco cardiovascular
Authors: Fiamoncini Tigre Inaê Luana , De Jesus dos Santos Dayane , Guedes Romeiro Clara Maria , Santos Souza Almeida Fabyanne , Monteiro da Cruz Cristiane
Published: April 2024

Os indicadores antropométricos são os índices da aferição do peso, altura, dobras cutâneas, circunferência   abdominal (CA),  índice  de  conicidade  (IC),  razão  cintura-estatura (RCEst), circunferência da cintura (CC), circunferência  do  quadril  (CQ),  relação  cintura-quadril  (RCQ) e o  índice  de  massa corporal (IMC), por exemplo. Nesse sentido, estudos anteriores têm relatado diferentes níveis de eficácia dessas medidas na identificação do risco de doenças cardiovasculares. Este artigo é uma revisão sistemática que visa analisar os índices antropométricos como prevenção de risco cardiovascular. As buscas foram realizadas, até fevereiro de 2024, em duas bases de dados: PubMed e BVS, usando os seguintes descritores: “Heart Disease Risk Factors” ;  “anthropometric indices” ; “coronary heart disease” e “abdominal circumference”. Observa-se que foram selecionados artigos que se evidenciaram relevantes para o tema proposto. Portanto, conclui-se que tais indicadores representam um conjunto de métodos de baixa complexidade e baixo custo, amplamente utilizados em estudos epidemiológicos e que estão associados com a avaliação de doenças cardiometabólicas.
Abordagem Terapêutica da Síndrome de Sjögren: uma revisão narrativa
Authors: Salgado Oliveira Raphaella , Leite Costa Adriel , Aemi Ohfugi Danielly , Miyuki Nishi de Castro Francine , Lucas Foltran Gustavo , Braz Gomes Vitoriano Larissa , de Figueiredo Andrade Júnior Márcio , Guimarães dos Santos Natália , Mitsuo Kakinoki Nomoto Nilton , Vasconcelos do Vale Aguiar Andrezza
Published: April 2024

Objetivo: Informar sobre o estado atual das evidências sobre a eficácia e segurança dos principais tipos de terapias aplicadas à Síndrome de Sjögren (SS). Revisão Bibliográfica: Atualmente não existe nenhuma substância curativa para a SS, sendo o objetivo terapêutico a melhora sintomática, a prevenção de danos sistêmicos e a melhora na qualidade de vida. Existem as terapias tópicas orais e oftalmológicas cujo objetivo é melhorar os sintomas da xerostomia e xeroftalmia, conhecidos como síndrome sicca. Sobre as terapias farmacológicas orais na SS, o foco principal é suprimir a atividade imune anormal em pacientes críticos. Quando o dano visceral está presente e grave, a terapia com glicocorticoides é utilizada além dos agentes imunossupressores como a hidroxicloroquina, metotrexato, rituximabe e os inibidores do fator de necrose tumoral.  Conclusão: Observou-se uma grande divergência no uso dessas drogas, por isso, existem poucas recomendações oficiais no uso da terapia farmacológica, fazendo com que muitas escolhas terapêuticas sejam baseadas na prática clínica. Assim, conclui-se que é necessário mais estudos para apoiar a decisão dos especialistas, bem como identificar aqueles pacientes que apresentarão mais benefícios com uma determinada terapia.
A IDEAÇÃO SUICIDA E A SÍNDROME DE BURNOUT EM MÉDICOS RESIDENTES – UMA REVISÃO BIBLIOGRÁFICA
Authors: Soares Isadora Veras Araújo , Teixeira Júlia Karolinne de Sousa , Brito Ana Clara Viana Soares , Ribeiro Camila Passos , Borges Gabriela Victor Alencar , Bezerra Lana Vitória Santana , Sá Rayanne Reis , Braz Guilherme Luiz Amorim , Nunes Ana Beatriz Valença Branco , Portes Vinicius Machado , Sousa Victor Eduardo Carvalho , Gomes Fernando Luiz Maia , Barros Wallace Smaly Carvalho , Monte Teresa Íris da Silva , Andrade Andréa Leite Nascimento
Published: April 2024

INTRODUÇÃO: A Síndrome de Burnout é composta por uma tríade caracterizada por exaustão emocional, distanciamento afetivo (despersonalização) e reduzida realização profissional. A ideação suicida é retratada de forma geral como um pensamento fugaz de falta de sentido na vida, podendo estender-se até uma forte inquietação quanto ao porquê de estar vivo ou a concepção de atos que levem ao fim da vida. OBJETIVOS: Compreender os fatores relacionados à presença de ideação suicida e síndrome de Burnout em programas de residência médica e colaborar com os estudos e entendimentos acerca dos mecanismos de tratamento e prevenção da ideação suicida e da Síndrome de Burnout na formação dos médicos residentes. MÉTODOS: Revisão bibliográfica realizada a partir da seleção de artigos e periódicos, publicados em Inglês e Português, entre 2001 a 2021, em plataformas online como SciELO, PubMed, Medline e DeCS. DISCUSSÃO: Apesar da correlação positiva, não há substrato teórico para concluir que a ideação suicida é desfecho provável da Síndrome de Burnout ou se a alta prevalência associada de transtornos psiquiátricos como a depressão é fator precipitante no aparecimento dos sintomas da ideação suicida. CONCLUSÃO: A prevalência de Burnout em médicos residentes é maior que na população em geral. A ideação suicida, apesar da menor prevalência, foi ainda mais evidente em indivíduos previamente diagnosticados com a Síndrome de Burnout. Algumas práticas que ajudam na redução dessas enfermidades são propiciar aos residentes experiências de atendimento voluntário, ações de prevenção em saúde pública, atendimentos na atenção primária e além de oferecer oportunidades de ministrar aulas e palestras para estudantes da área da saúde, o que auxilia na fuga do ambiente de estresse.
COMPARATIVE ANALYSIS OF FUNDING OF UNIVERSITY EDUCATION IN EU COUNTRIES
Authors:   INFOTECH, Greben Svitlana , Parashchenko Liudmyla ,   KROK University, Salii Bogdan ,   KROK University
Published: April 2024

This paper conducts a comparative analysis of the funding models for university education in the European Union (EU), focusing on government, private, and alternative funding sources. Purpose of the study is to analyze and compare the different funding models for university education in the EU and evaluate their efficacy. The basis of the study was the scientific works of researchers from different countries of the world and the OECD report, which presents the features of public, private and alternative financing of higher education. The main methods used in the article are methods of analysis and synthesis, comparative analysis and generalization. The analysis examines how these funding models impact accessibility, quality, and sustainability of higher education across different EU member states, including Germany, Sweden, the United Kingdom (pre-Brexit), and Italy. Through a review of existing literature and an evaluation of different funding mechanisms, the study identifies key trends and outcomes associated with each funding type. The paper also explores how European integration and policies influence these funding mechanisms. By comparing models across various countries, this analysis aims to highlight best practices and recommend policy enhancements to harmonize educational opportunities and meet future economic and social demands. The study recommends that EU countries consider a balanced approach to funding that combines the strengths of government support, private investment, and innovative funding mechanisms. This approach should aim to ensure equitable access to high-quality education while fostering financial sustainability and adaptability to changing economic conditions. Further, the paper suggests that ongoing evaluation and adaptation of funding models are essential to address the evolving needs of students and the broader socio-economic landscape. These findings and recommendations contribute to a deeper understanding of the complexities and dynamics of funding university education in the EU, providing a foundation for policymakers to enhance the effectiveness and fairness of higher education systems across Europe.
ASSESSING THE EFFECT OF ONLINE BANKING SERVICE QUALITY ON CUSTOMER LOYALTY IN MALAYSIAN BANKING INDUSTRY: THE MEDIATING ROLE OF CUSTOMER SATISFACTION
Authors: Noormajidah Nordin  , Selvan Perumal  , Maria Abdul Rahman
Published: April 2024

Technological improvements have greatly transformed the modern banking business, specifically through the substantial expansion of online banking. Online banking represents an innovative information system consuming the creative resources of the Internet to facilitate access for bank customers to an increasing array of financial services. Understanding the importance of high-quality online banking services in promoting customer loyalty is necessary for remaining competitive and establishing success in this rapidly changing and competitive industry. In response to this fundamental change, the banking industry has used digital methods to improve the way services are provided and to increase customer satisfaction and loyalty. This paper aimed to evaluate the effect of online banking service quality on customer loyalty in the Malaysian context. A survey is conducted for this purpose and a sample of 268 respondents is chosen which includes males and females. A self-administered questionnaire is used for data collection. The study found significant factors affecting the adoption of online banking, involving convenience, website quality, privacy, and security. This study provides important advertising understanding for banking professionals involved in the development and implementation of online banking products. Furthermore, the study has ramifications for policymakers seeking ways to encourage an online environment by highlighting key issues that require careful attention.
KEYWORDS: Banking Industry in Malaysia, Loyalty, Online Banking Service Quality, Customer Satisfaction.
FREIBERG INFRACTION SCOPING REVIEW
Authors: Bryam Esteban Coello García  , Sebastián Cardoso Gives  , Lucy Paulette Zumba Ríos  , José Javier Ordóñez Cabrera  , Jessica Vanessa Sibri Lazo  , Andrea Estefania Lopez San Martín  , Leidy Mariela Ordóñez León  , Carolina de la Nube Chasi Inga  , Tatiana Katherine Flores Ochoa  , Katherine Cecibel Barzola Suárez
Published: April 2024

Introduction: Freiberg's infringement is an osteochondrosis of the metatarsal bone heads, primarily of the second or third metatarsal. It is usually a chronic and progressive process that gradually causes pain and loss of normal function of the metatarsophalangeal joint.
Objective: to detail the current information related to Freiberg's disease, etiology, epidemiology, pathophysiology, clinical history, evaluation, differential diagnosis, treatment, prognosis, complications and postoperative period.
Methodology: a total of 32 articles were analyzed in this review, including review and original articles, as well as clinical cases, of which 26 bibliographies were used because the other articles were not relevant for this study. The sources of information were PubMed, Google Scholar and Cochrane; the terms used to search for information in Spanish, Portuguese and English were: Freiberg infraction, Freiberg disease, metatarsalgia, osteochondrosis.
Results: Freiberg's disease is the only osteochondrosis that is more frequent in women with a ratio of 5:1 in relation to men. Bilateral involvement is reported less than 10% of the time. The involvement primarily involves the second metatarsal in 68% of cases, the third metatarsal in 27% and the fourth metatarsal in 3% and the fifth is rarely affected.
Conclusions: Freiberg disease is an osteochondrosis of the metatarsal bone heads, commonly found in second or third metatarsals and common in women and athletes. Osteochondroses are a group of disorders resulting from a lesion of the epiphysis that modifies endochondral ossification and generates irregularity in the articular surface. The pathophysiology of Freiberg's disease is multifactorial. Affected individuals present with pain and swelling located in the affected metatarsal head area of the forefoot. Diagnosis can be confirmed by physical examination and radiographs. Conservative treatment should first be attempted to relieve symptoms and decrease epiphyseal deformity to restrict progression to arthritis regardless of the severity of the disease. There are a number of surgical techniques described for the treatment of Freiberg's disease if conservative treatment fails.
Key words: bone infraction, Freibergs disease, metatarsalgia, osteochondrosis, metatarsals.
Recruiting faculty members at the University of the Emirates for the implementation of artificial intelligence applications in the educational process: "A field study within the framework of the Unified Theory of Acceptance and Use of Technology."
Authors: Bilal Amel Anbar Bashir , Almahallawi Dr. Wesam
Published: April 2024

The research focused on the factors influencing the behavioral intention of faculty members in the Department of Media and Creative Industries at the College of Humanities and Social Sciences, United Arab Emirates University, to adopt and utilize artificial intelligence applications in education. This study is a descriptive research project that aims to shed light on a particular phenomenon or problem under the direction of the Unified Theory of Acceptance and Use of Technology (UTAUT). To gather data, a descriptive survey employing a questionnaire was administered to a sample of 11 faculty members from the aforementioned department. Among the findings, the most prominent was the dominant influence of social factors, contributing 53% to the intention to use AI tools. The factor of available facilities, which came in second place at 37.1%, was close behind this. In contrast, neither the expected performance nor the expected effort factors exhibited a significant impact on the participants' intention to integrate AI applications into their work.
Key words: Artificial intelligence Applications, Educational process, Unified theory of acceptance and use of technology (UTAUT), UAEU
Genesis of the conceptual and categorical apparatus of the study of the process of sales of agricultural enterprises
Authors: Biloshapka Yurii
Published: April 2024

The article is devoted to the study of the formation of the conceptual and categorical apparatus of the process of sales of agricultural enterprises. Solving the problem of increasing the economic efficiency of the main activity of enterprises through more efficient sales of their products is a complex and multifaceted task. This implies a resounding justification for the rational distribution of products in the market. This, in turn, requires clarification and adaptation of specialized terminology for studying the sales process of agricultural enterprises. In studying the genesis of the conceptual and categorical apparatus of the sales process of agricultural enterprises, distribution is defined as a complex process covering various aspects, including wholesale and retail functions, transportation, storage, and interaction with consumers. It has been found that different researchers provide their definitions of distribution, focusing on different aspects, which can lead to confusion in terminology and complicate analysis. It is determined that, historically, the distribution of production is considered an essential element of the management of enterprise activities, especially in transitional periods of economic development. In this context, "distribution" is often associated with "marketing," making it difficult to research. It is disclosed that the system of distribution of products includes various subjects of economic relations, creating specific systems for the movement of products from the producer to the consumer. Analysis of the definitions of well-known experts allows us to formulate more accurate and generalized approaches to understanding these concepts, which consider the effectiveness and subjectivity of product distribution. Such approaches contribute to a better understanding of the essence and functions of distribution and its significance for the subjects of economic relations. Thus, the distribution of products acts as a critical element of economic reproduction, ensuring the delivery of goods to the consumer and forming the economic results of the activities of entities in the production and circulation of products.
Keywords: commodity, sales, distribution, commodity movement, market of agricultural products, marketing.
Supporting the Development of Classroom Reading Corner Program at Madrasah Ibtidaiyah Muhammadiyah 01 Pekanbaru Title
Authors: Rizky Ramanda , Syahdan Syahdan , Suharni Suharni
Published: April 2024

The habit of reading should be introduced to children at an early age for them to continue reading throughout their lives. A well-planned and facilitated program for habituating readers is therefore necessary. This Community Service activities aim to provide assistance for the development of the Class Reading Corner Program at Madrasah Ibtidaiyah Muhammadiyah 01 Pekanbaru. Following a review of the school's problems regarding the lack of reading corners, a limited number of children's reading books, and the lack of governance of class reading corners, these activities were carried out based on the results of an analysis of these problems. As part of this program, 48 sets of children's picture books were handed over, including mini bookshelves. The program also socialized development of reading corner program and made a simulation of making picture books involving 14 teachers, 1 administrative staff, and 1 headmaster. This program employed a direct observation and questionnaire for the evaluation. The observation showed that three classroom reading corners are present and in use at the school. A satisfaction level of 89.6% was obtained from activity participants after analyzing the questionnaire, an increase of 29.20% over that obtained prior to socialization and simulation. Furthermore, 93.75 % of the participants wanted a reading corner and 100% indicated that there was a need to enhance or improve its quality. The results from these studies suggest that this mentoring program has achieved a positive effect by raising awareness of the importance of increased reading proficiency in schools.
Tobler goes digital
Authors: Sonderegger Viviane
Published: April 2024

The digital edition project "Tobler goes digital" provides online access to a collection of almost forgotten folk songs by the Swiss composer Johann Heinrich Tobler (1777-1838), bringing a rich choral music repertoire back into the limelight.
Interview
Authors: Scharrer Ulf
Published: April 2024

In response to historian Ulf Scharrer‘s questions about individual creative crises in music-theatre production, the stage director Alexander Nerlich talks about what he perceives to be the more fundamental structural, societal and artistic crises of our times.
Geisterhände – neu belebt
Authors: Bausch Sebastian , Bärtsch Manuel
Published: April 2024

Since more than 15 years, the Bern University of the Arts (HKB) has been researching early 20th century piano and organ rolls. In the SNF‑AGORA‑Project "Magic Piano", researchers are seeking ways to make the recordings and related insights accessible to a larger public through the website www.magic-piano.ch.
Effect of Social Stressors on Work-Family Conflict Experienced by Female Faculty Members at Public Sector Schools in District Lahore, Pakistan
Authors: Dr. Raham Zaid  , Muhammad Zubair  , Muhammad Faisal Rehman  , Rubina Nadeem  , Dr. Syed Zubair Haider  , Farid Ullah Khan
Published: April 2024

The goal of this study is to find out how work-family conflict (WFC) affects the quality of service that female school faculty provide. A healthy balance between work and personal life includes both work and personal activities. Because their workloads are getting bigger, it's getting harder for women faculty members to balance work and family life. The gender gap puts more stress on the female faculty, which makes it harder for them to give good care. This study uses a positivist research paradigm to get information from female teachers in Pakistan's Lahore District public schools. The focus of this study is on female teachers from a variety of public schools in District Lahore, Pakistan. For this study, a representative sample of female teachers from 203 public schools in the Lahore District of Pakistan was chosen. Cronbach's Alpha (Sarstedt et al., 2019) ranges from 0.681 to 0.931 and a composite range of 0.826 to 0.954, which shows that the results of this study can be trusted. The Fornell-Larcker criterion (Henseler, 2015), cross-loadings, and heteronormativity are used to figure out whether the results are similar or different. Structured equation modelling (SEQ) is used to look at the data (Cheung & Wang, 2017). This study found that role ambiguity and role conflict at work, as well as interactions between parents and spouses at home, have a negative effect on WFC. People are affected by work pressures, which can lead to job stress and, in the long run, depression. When women in the academic workforce experience WFC, it makes their depression worse. Respondent views of ISQ were average when it came to dependability, empathy, responsiveness, and concreteness (Reynoso et a., 1995). WFC hurts the ISQ of female faculty members because it makes them more likely to get depressed. This study also shows that more research needs to be done using different methods, like qualitative analysis and triangulation. This means that in Pakistan, WFC in female faculty can be studied in both public and private schools. Lastly, the study makes some suggestions for future research on WFC and gives management some tips on how to help the female faculty members raise the ISQ.
Keywords: Work-Family Conflict (WFC) in Pakistan; Causes of Work-Family Conflict; Consequences of Work-Family Conflict; Female Faculty Members in Public Sector Schools and Work-Family Conflict; Internal Service Quality (ISQ) and Work-Family Conflict
The Supervisory Function of PT ASDP over Ferry Service Providers at Kolaka Port
Authors: Ningsih Sudarmi , Agusman Yudi , Asis Laode Asrun , Hidayat Rahmat , Muzakkir Abd. Kahar
Published: April 2024

This research aims to analyze the supervisory function of PT ASDP regarding the services of ferry companies at Kolaka Port. This research uses an inductive qualitative analysis. Inductive analysis is an approach that begins with field facts, analyzes them based on relevant theories and arguments, and ultimately yields a conclusion. The results show the discrepancies between theoretical and practical aspects of PT ASDP supervision, particularly in direct versus indirect supervision within social and economic interactions on ships, notably concerning ongoing mat rental practices despite existing reprimands and routine inspections. Additionally, the lack of regulation for mat rental practices creates legal uncertainties and potential disturbances, suggesting a more comprehensive supervisory approach encompassing preventive, repressive, and internal and external elements to address these issues. The presence of mats in outdoor areas causes passenger discomfort, and interactions between the government and related parties in resolving these issues underscore the necessity for evaluating and refining existing supervision mechanisms. Therefore, it is recommended that PT ASDP enhances the effectiveness of both direct and indirect supervision of ferry services at Kolaka Port by integrating a more comprehensive supervisory approach, including preventive aspects to anticipate potential issues and repressive measures for violations. It necessitates reviewing and refining ship regulations to incorporate clear rules regarding mat rental practices and ensure strict supervision of these regulations' enforcement. Related government agencies are advised to collaborate closely with PT ASDP to develop effective policies and supervisory mechanisms and conduct public awareness campaigns to underscore the importance of regulatory compliance. NGOs could play a role in monitoring the implementation of supervision and providing constructive feedback for improvements. The community is also encouraged to monitor and report discrepancies to support collective efforts to enhance future ferry service quality.
Analisis Sistem Pengendalian Intern atas Penerimaan Kas pada PT Bank Sumut
Authors: Aritonang Berliana , Samosir Hendrik E. S. , Hutapea Herti Diana
Published: April 2024

PT Bank Sumut is a BUMD company in Indonesia which operates in the business sector of banking services and financial services products. PT Bank Sumut functions as a driver of the pace of development in the region and acts as a regional cash holder by carrying out business activities as a commercial bank. Cash is an asset that is very easily transferable and ownership cannot be proven. Therefore, it is necessary to have a cash control system that aims to control all company activities. This research aims to analyze and find out whether the internal control elements for cash receipts that have been determined are in accordance with those carried out by PT Bank Sumut. The type of data used in this research is document data and the data source is primary data. The data collection techniques used are interview and documentation techniques. And the analysis technique used in this research is descriptive and comparative, namely an analysis method by first collecting, classifying and interpreting data so that it can provide a clear picture of the problem being studied, then comparing the results with their application.
Adverse drug events among hospitalized COVID-19 patients. Experience with the Global Trigger Tool
Authors: Mishinova S. A. , Kolbin A. S. , Verbitskaya E. V. , Alekseeva N. P. , Gomon Yu. M.
Published: April 2024

The Global Trigger Tool is a reliable method for detecting adverse events, demonstrating positive predictive value and significant sensitivity among patients with COVID-19.

The objective of this study was to develop and apply an adapted Global Trigger Tool to identify potential adverse events among hospitalized patients with moderate to severe COVID-19.

Materials and methods. The study included a literature review, analysis of spontaneous reports n=873 in the national database of the Russian Federation for the COVID-19 indication for the period 2020–2022, and application of the trigger tool in a single-center retrospective study n=329. Statistical processing was performed by the method of disproportionality with the determination of the odds ratio of reporting. The symptom-syndrome method based on parameterization of interaction effects using Zhegalkin polynomials was used to identify significant effects of drug associations; Fisher’s exact test was used to select the most significant associations for occurrence.

Results. Among the triggers with a frequency of 10 or higher in terms of mortality rate (≥80%), the leading ones were: pulmonary edema, hypotension, and respiratory failure, which is consistent with the COVID-19 clinical course of the disease. A disproportionately high incidence of respiratory failure was associated with favipiravir use. Leukocytosis associated with tofacitinib use and drug-induced liver damage associated with tocilizumab use.

Conclusions. The identified potential adverse events and their associated mortality risks among patients with moderate to severe COVID-19 allow for compliance with current clinical guidelines for the management of patients with COVID-19.
Relationship between renal damage marker levels and the presence of bleeding in patients with atrial fibrillation and chronic kidney disease receiving rivaroxaban
Authors: Shatalova N. A. , Ostroumova O. D. , Korotkova T. N. , Vorozhko I. V. , Klychnikova E. V. , Ebzeeva E. Yu. , Godkov M. A. , Starodubova A. V. , Mirzaev K. B. , Sychev D. A.
Published: April 2024

Relevance. Chronic kidney disease (CKD) is often concomitant pathology in patients with atrial fibrillation (AF). Because of the increased risk of bleeding in patients with AF and CKD while taking anticoagulant therapy, it is necessary to assess new methods for predicting the risk of bleeding when prescribing anticoagulants in this category of patients.

Objective. To evaluate the possible relationship between the presence of bleeding in patients with AF and CKD C3–4 receiving rivaroxaban and the level of renal damage markers in urine.

Methods. One hundred and thirty-three patients with AF and CKD C3a-C4 aged 52 to 97 years (median age 82 [74;86] years) were included in the study. All patients were assessed for bleeding and excretion of markers of renal damage (albumin; nephrin; neutrophil gelatinase-associated lipocalin (NGAL), and kidney injury molecule-1 (KIM-1)) in with urine have been identified. In addition, the levels of kidney injury markers in the urine of 45 healthy volunteers were analyzed.

Results. Urinary NGAL and KIM-1 levels in patients with AF and CKD with a history of bleeding (5.5 [3.81;23.83] ng/ml and 0.68 [0.27;1.10] ng/ml, respectively) were significantly higher than those in patients without bleeding (4.19 [2.22; 15.53] ng/ml, p=0.039, and 0.38 [0.13;0.66] ng/ml, p=0.019, respectively) and healthy subjects (2.6 [1.9;4.3] ng/ml, p<0.001, and 0.21 [0.10;0.69], p=0.003, respectively).

Conclusion. Patients with AF and CKD C3a — C4 on rivaroxaban treatment with a history of bleeding have higher urinary excretion of KIM-1 and NGAL.
Ideal recruitment rate in clinical trials in phases II–III
Authors: Milovanov S. S.
Published: April 2024

Actuality. The speed of patient recruitment into a clinical trial allows us to evaluate the work of the clinical center and calculate the time required to achieve targeted recruitment. The authors estimate the recruitment rate on the basis of comparison with the target recruitment value, and according to the literature, the recruitment rate is influenced by many factors, which mainly have a negative effect, reducing it. Assessments of the optimality of recruitment or the normality of recruitment of patients according to the literature were always made based on a specific protocol and nosology because this parameter cannot be constructed experimentally under ideal conditions in the absence of the influence of one or another factor. On the other hand, most clinical trials fail to recruit patients, and accordingly, the recruitment rate in such studies was strongly influenced by certain factors. For the first time, we assessed the patient recruitment rate in successful studies when calculating the degree of influence of the nosology and found the ideal recruitment rate, i. e., the recruitment rate with zero influence of the factor.

Objective. To quantify the degree of influence of the nosology factor of the protocol on the recruitment rate of patients in a clinical trial.

Materials and methods. A retrospective analysis of 4 international multicenter clinical trials of II–III phases was conducted on the recruitment of patients depending on the influence of the nosology factor of the protocol. Descriptive statistics using the typing and odds ratio technique.

Results and discussion. A quantitative assessment of the influence of the nosology factor of the protocol on the rate of patient recruitment was obtained. Found the ideal typing speed.

Conclusions. For the first time, a quantitative assessment of factors influencing patient recruitment has been proposed. For the first time, the ideal recruitment rate has been determined.
Marketing analysis of the Russian pharmaceutical market of oxaliplatin
Authors: Gopienko I. A. , Zyryanov S. K.
Published: April 2024

Relevance. Colon and ovarian cancer occupy leading positions in the structure of morbidity and mortality among malignant neoplasms in Russia. One of the widely used drugs for the treatment of these nosologies is oxaliplatin, but there is no relevant information to assess its availability and share among other antitumor drugs.

Objective. Analysis of the Russian pharmaceutical market for oxaliplatin drugs among other antitumor drugs in 2015–2022.

Materials and methods. For the analysis, reports from marketing agencies DSM Group and IMS were used, both in value and in physical terms.

Results. During the period under study, significant changes occurred in the Russian pharmaceutical market of antitumor drugs: the volume of sales and consumption increased, which was also accompanied by a decrease in the cost of drug units per package (all antitumor drugs) and course of use (oxaliplatin). At the same time, the share of Russian manufacturers of antitumor drugs has increased. In relation to oxaliplatin, during the study period there was almost complete displacement of the original drug from the market by generic drugs. An intensive process of import substitution was also observed: the share of domestic drugs increased by the end of the study period in value and volume terms to 93 and 95%, respectively.

Conclusion. Identified changes in the Russian pharmacological market for 2015–2022 reflect an increase accompanied by an increase in the availability of antitumor drugs and, in particular, oxaliplatin.
Current issues of increasing the availability of innovative therapy for the treatment of patients with non-small cell lung cancer within the Russian healthcare system
Authors: Laktionov K. K. , Zyryanov S. K. , Artamonova E. V. , Smolin A. V. , Reutova E. V. , Zhuravleva M. V. , Kolbin A. S. , Frolov M. Yu.
Published: April 2024

The advisory board was held to discuss he current situation with diagnosis and treatment of advanced non — small cell lung cancer with a mutation in the MET gene (aNSCLC with METex14). Lung cancer takes a leading place in the structure of oncological diseases in Russia. The frequency of molecular abnormalities in the MET gene patients with advanced lung cancer is 3%, the NGS method is the most effective in identifying this alteration.

The effectiveness of capmatinib, a MET tyrosine kinase inhibitor was confirmed in the GEOMETRY mono-1 registry trial: the objective response rate in the patients with aNSCLC with METex14 who had previously received 1–2 lines of therapy was 41%, among those who had not previously received treatment — 68%. Median duration of response was 9.7 month in previously treated patients with aNSCLC with METex14 and 12.6 months in the treatment — naïve patients with aNSCLC with METex14. Intracranial response was observed in 54% of cases among patients with aNSCLC with METex14. In addition, the efficacy of capmatinib was confirmed when it is administered to the patients with aNSCLC with METex14 in real-world clinical practice. Other therapeutic options (immune-oncology therapy, chemotherapy) are less effective in case of this disease variant.

Based on the data on effectiveness and tolerability of capmatinib, the expert group made a decision to recommend inclusion of capmatinib in the Russian Clinical Guidelines for the treatment of lung cancer and into the Essential Drug list.
Circadian marker in duodenal ulcer
Authors: Esedov E. M. , Musaeva L. N.
Published: April 2024

The purpose. To study the content of melatonin in venous blood, to assess the seasonal variability of the hormone in patients with duodenal ulcer (DU) and to establish a possible relationship between the studied parameters.

Material and methods. 45 patients with varying clinical activity of DU during exacerbation and during treatment were examined. Determination of melatonin in venous blood was carried out using high-performance liquid chromatography with tandem mass spectrometry. To assess the condition of the duodenum, fibrogastroduodenoscopy of the gastroduodenal zone we used Exera (cIF160) and Olympus endoscopes.

Results. It has been established that in the active stage of DU the levels of the hormone melatonin are reduced. In order to study the possible effect of light illumination on melatonin content, we studied the production of this indole in groups of patients with DU at different times of the year. It turned out that the melatonin content was significantly lower in the group of patients with peptic ulcer disease in winter and spring.

Conclusion. The regression and correlation analysis carried out revealed a positive moderate dependence of the melatonin indicator on the duration of daylight hours in the venous blood. Clinical remission of DU after 2 months was accompanied by an increase in melatonin production.
PREVALENCE AND CHARACTERISTICS OF ALLERGIC DISEASES
Authors:   DSc, dotsent, Bukhara State Medical Institute, Uzbekistan, Z. Kh Babadjanova
Published: April 2024

Allergic diseases(AD) are one of the most urgent problems of modern medicine. The prevalence of bronchial asthma in children and adults in the Bukhara region was studied. The primary incidence of bronchial asthma in the age structure of the population was studied according to the coupons of an outpatient patient (form No. 025-12u) for 2015–2019 in 10 age groups (1–5 years, 5–9 years, 10–14, 19, 20–29, 30–39, 40–49, 50–59, 60 and older) in the city of Bukhara and twelve districts of the Bukhara region.The study of the distribution of indicators of the incidence of bronchial asthma in the Bukhara region revealed that the areas of risk for this pathology are areas with industrial zones: Karakul, Karulbazar and the city of Kagan. The risk groups for the incidence of bronchial asthma are children under 9 years of age and adults aged 60 years and older. The prevalence of bronchial asthma ranges from 5.5 per 1,000 population in relatively clean areas of residence to 33.5 per 1,000 population in industrialized areas.Thus, the study showed that the highest incidence of general morbidity with bronchial asthma in children and adults is observed in the city of Kagan with the operation of an oil extraction plant, in the Karaulbazar district with an oil refinery and in the Karakul district with a Kandim gas processing plant. An increased risk of primary incidence of bronchial asthma exists for children aged 3 to 9 years and for adults 60 years of age and older.
EDUCATION OF ETHNOCULTURAL TOLERANCE IN STUDENTS IS STUDIED AS A PEDAGOGICAL AND PSYCHOLOGICAL PROBLEM
Authors:   Samatkand State Medical University, Uzbekistan, Sayfullayevich Tangirov Eldor
Published: April 2024

In this article, the explanation of the scientific views on the education of ethnocultural tolerance in students as a pedagogical and psychological problem is given.
AN ANALYSIS OF THE IRRIGATION INFRASTRUCTURE IN SAMARKAND PROVINCE AT THE TURN OF THE 20TH CENTURY
Authors:   Researcher of SamSU, Uzbekistan, Akhtamovich Melikov Nadir
Published: April 2024

At the outset of the 20th century, the Soviet government, driven by pertinent political and economic objectives, commenced the implementation of a policy aimed at the development of the irrigation system and the construction of reclamation facilities in Uzbekistan. Consequently, to optimize the utilization of irrigated lands within the republic, efforts were made to enhance the mechanization of agricultural operations, consolidate small irrigation areas, emphasize the leveling of irrigation territories, andexpand the scope of irrigation and reclamation activities.
THE RELATIONSHIP OF LOW BIRTH WEIGHT (LBW) WITH DEATH NEONATAL IN INDONESIA (2017 IDHS DATA ANALYSIS)
Authors: Rostina Rostina , Arlianti Nopa , Abdullah Asnawi
Published: April 2024

Background: Neonatal mortality is a reflection of a country's health status and until now, health development is still an important government program. The purpose of this study was to determine the relationship between Low Birth Weight (LBW) and neonatal mortality in Indonesia after confounding factors (education, household wealth index, age, smoking, parity, birth spacing, antenatal visits and history of abortion) were controlled and to determine the size of Population Attributable Risk of LBW to neonatal mortality in Indonesia. Indonesia 2017. Methods: The design of this research was cross-sectional with multivariate logistic regression analysis using secondary data from the 2017 IDHS. The sample in this study were women who had been married and gave birth to live babies from 2012-2017 as many as 16.343 samples. Results: The study showed that there is a relationship between LBW and neonatal mortality (OR=6.79, 95% CI=4.98-9.26, p value=0.000). Then the dominant factor that is most related to neonatal mortality is LBW with a p value of 0.000 and parity with a p value of 0.005. Conclusion: In order to reduce neonatal mortality, it is hoped that the government and the society can play an active role in reducing and controlling LBW by increasing antenatal care. As well as encouraging pregnant women to check their pregnancies and deliveries by skilled health workers.
DETERMINATS OF PATIENT SATISFACTION IN MEDICINE COLLECTION SERVICES AT PHARMACEUTICAL INSTALLATION BANDA RAYA HEALTH CENTER IN BANDA ACEH
Authors: Putra Utama Anugerah Akbar , Arbi Anwar , Lina Intan
Published: April 2024

Background: The Banda Raya Health Center (Puskesmas), reports that the number of patients who  purchase medicines from the pharmacy at the Community Health Center Installation is decreasing every year, this is thought to be because the medicines  needed are not available at the pharmacy. Patients who do not want to queues for a long time and prefer to buy medicines from the outside of the health center. Convenience and poor service procedures are also the reasons why patients feel dissatisfied with medication collection services. This study aims to determine patient satisfaction in  medicine collection services at the the Banda Raya Community Health Center Pharmacy Installation, Banda Aceh City. Method: Quantitative research with cross sectional design. The sample in this study were patients/families of patients who purchase  medication at the Banda Raya Health Center Pharmacy Installation, totaling 49 patients from January to March 2020, using the Accidental Sampling technique. This research was conducted on August 3-11, 2020. Bivariate analysis used SPSS with the chi square statistical test. Results: Univariate analysis showed that 69.4% of patients were dissatisfied, 75.5% were uncomfortable, 67.3% had a negative attitude, 73.5% had poor human relations, 75.5% had poor service procedures, and 77.5 % no drug availability. The results of the bivariate analysis showed that there was a relationship between comfort (P value = 0.004), attitude (P value = 0.002), human relations (P value = 0.001), service procedures (P value = 0.001), and drug availability (P value = 0.021 ) with patient satisfaction in drug collection services at the Pharmacy Installation of the Banda Raya Health Center, Banda Aceh City. Conclusion: Puskesmas are expected to be able to provide sufficient medicine and provide training for pharmaceutical service staff regarding good health service training such as carrying out the ‘3 S’ (Greet, Smile, Care) so that patients feel satisfied and comfortable.
Christian Faith and Doctrine: A Tool for Sustaining Peace in Nigeria
Authors: Ayoola Adebola Racheal
Published: April 2024

Nigeria is a nation of three major religious groups that has different faith dynamism and practices. The history of Nigeria as a country will not be complete without a research on the issues currently threatening the peace of the nation. More so, over the years, the issue of the diversity in the ethnic groups and tribes has contributed to the division among Nigerians and has done more harm than good in fostering peace and unity in the country (Nweke 2018).  Religious and ethnic sentiment has also contributed negatively to the growth and developmental sustainability of Nigerians a whole. What is Christian faith and doctrine? What constitutes the Christian doctrine?  What are the teachings and values expected of a Christian in order to bring peace to the country?  What role can Christian faith, teachings and practices play in the sustainability of peace in Nigeria? This paper provides succinct answers to these questions. The paper adopted a descriptive and analytical research approach.  The research revealed that Christianity just like the other two religions in Nigeria is an advocate of peace and they it also creates a sense of dependence and oneness among human beings (Churchill & Michael 2023). The paper concludes that Christianity is an indispensable tool in sustaining peace in Nigeria since it comes with teachings and practices worth emulating. This paper recommends that people should be sensitized about the importance of sustaining peace in Nigeria. However, the effective teaching of religious studies and uplifting of moral and spiritual values by the religious leaders will go a long way to bring about peace in Nigeria.
Counselling Approaches and Educational Support for Business Education in Students with Visual and Hearing Impairments: Enhancing Accessibility and Learning Outcomes
Authors: Olowe Modupe Oluwatoyin , Olowe Nihinlola Eunice
Published: April 2024

This qualitative study delves into the counselling and educational support for Nigerian business education students with visual and hearing impairments through interviews with 15 professionals, including educators, counsellors, and administrators. It reveals a critical lack of accessible educational resources and assistive technologies, highlighting the suboptimal effectiveness of existing support due to insufficient trained staff. Professionals suggest a comprehensive approach to improvement, advocating for the creation of accessible materials, enhanced training, investment in technologies, and policy reforms to overcome these barriers. The study calls for immediate systemic changes to facilitate better accessibility and proposes future research to encompass longitudinal studies, the impact of socio-economic factors, and broader inclusion of student and family perspectives to foster a genuinely inclusive educational environment.
Identification of Three Novel Lipid Metabolism-Related Long Non-Coding RNAS (GHRLOS, Lnc-GHRL-3:3, and LINC00852) As Potential Biomarkers and Regulators for Diabetic Dyslipidemia
Authors: Anbari Dalia M. , Al-Harithy Rowyda N.
Published: April 2024

Type 2 diabetes mellitus (T2DM) is a metabolic disease that affects both young and old people. The prevalence of T2DM is increasing worldwide and is reaching epidemic proportions. It is associated with a dysregulation of lipid metabolism that favors the development and progression of many diseases, including diabetic dyslipidemia. Therefore, in-depth studies are needed to understand the epigenetic mechanisms of diabetic dyslipidemia, especially at the molecular level. However, the underlying mechanisms are still largely unknown. In the current investigation, we aimed to elucidate novel potential lipid metabolism-related long non-coding RNAs (lncRNAs) that regulate diabetic dyslipidemia development and provide novel signatures for its prognosis and precise treatment. HbA1c levels and lipid profiles were analyzed in 71 T2DM patients and 32 non-diabetic controls using established assays. The expression patterns of the genes GHRLOS, lnc-GHRL-3:3, and LINC00852 were detected by quantitative real-time polymerase chain reaction (qRT-PCR).The results showed that the expression levels of the lncRNAs GHRLOS, lnc-GHRL-3:3, and LINC00852 were significantly (P < 0.0001) higher in diabetics compared to non-diabetics. Pearson’s correlation analysis showed that the expression levels of GHRLOS, lnc-GHRL-3:3, and LINC00852 were significantly and negatively correlated with HbA1c, TC, TG, LDL, and VLDL and positively correlated with HDL. The results of the linear regression analysis confirmed the correlation in the same direction and the significance value of Pearson coloration coefficient analysis. Finally, it can be concluded that the lncRNAs GHRLOS, lnc-GHRL-3:3, and LINC00852 show a significant correlation with dyslipidemia in T2DM patients, indicating their potential roles as biomarkers and regulators of diabetic dyslipidemia.