bluuebunny/crossref_metadata_2025 huggingface dataset:
ECONOMIC ANALYSIS OF DIFFERENT IRRIGATION DEPTHS IN FORAGE SORGHUM CROPS
Authors: RODRIGUES DE SOUSA PAULO GLEISSON , DE ARAÚJO VIANA THALES VINÍCIUS , DE CARVALHO CLAYTON MOURA , FIRMIANO DE SOUSA JOSÉ DE PAULA , CAMPOS KILMER COELHO , DE AZEVEDO BENITO MOREIRA
Published: November 2020

The objective of this work was to evaluate the production costs and profitability indexes of sorghum crop for silage production under different irrigation depths. The work was conducted at the Federal Institute of Education, Science and Technology of Ceará (IFCE) – Umirim Campus, from September to December 2016. The treatments were arranged in 5 x 5 split plots with 5 replications. Irrigations were performed on a daily basis, and the applied depths were calculated based on crop evapotranspiration (ETc). The primary treatments were 50, 75, 100, 125 and 150% of ETc, associated with different levels of carnauba bagana mulch (0.00, 2.50, 3.75, 5.00, and 6.25 cm). Effective Operating Cost (EOC), Total Operating Cost (TOC), Gross Revenue (GR), Operating Profit (OP), Profitability Index (PI) and Break-Even Price (BEP) were estimated. According to the indicators analyzed, it was found that this is a promising crop within the different agricultural production schools, with favorable rates for the producer. The variety evaluated presents high resistance as to the water limitation factor, showing positive indicators such as break-even point below the average prices practiced in the region.
PRODUCTIVE PERFORMANCE OF MAIZE CROP IRRIGATED WITH AND WITHOUT WATER DEFICIT IN DIFFERENT PLANT ARRANGEMENTS
Authors: CARVALHO MARCUS WILLAM LOPES , BASTOS EDSON ALVES , CARDOSO MILTON JOSÉ , ANDRADE JÚNIOR ADERSON SOARES DE , SILVA MARCELO RIBEIRO
Published: November 2020

The objective of the present study was to evaluate the effects of row spacing and planting density, under different water regimes, on dry grain production of the maize hybrid AG -1051, in Teresina, Piauí. Two experiments were conducted with the use of a conventional sprinkler system for irrigation, being one with 100% and the other with 50% crop evapotranspiration (ETc) replacement. A randomized block experimental design was used, in a 5x2 factorial scheme, combining five planting densities (PD) (20,000; 40,000; 60,000; 80,000; and 100,000 plants ha-1) and two spacings between rows (RS) (0.5 and 1.0 m), with four replications. The weight of 100 grains, cob percentage, grain yield, and water use efficiency were evaluated. The increment of planting density caused a linear decrease in the 100-grain weight and increment of the cob percentage in relation to the total ear weight. Under full irrigation regime, the combination of the 0.5 m row spacing and planting density of 72,000 plants ha-1 provided maximum yield of 7.2 Mg ha-1. Under water deficit condition, the maximum yield of 4.8 Mg ha-1 was reached in the combination of the 0.5 m row spacing and planting density of 67,000 plants ha-1..The total water depth of 419 mm provided maximum WUE of 1.70 kg m-3. The total water depth of 268 mm caused a reduction in WUE with maximum point of 1.54 kg m-3.
Apresentação
Authors: Ladwig Nilzo Ivo
Published: November 2020

O volume 26, edição 2020 da Revista Tecnologia e Ambiente, em seus artigos que ora apresentamos à comunidade científica e geral são frutos de pesquisas interdisciplinares publicadas em tempos de PANDEMIA.Interdisciplinaridade na pesquisa tem como objetivo a compreensão do homem e a transformação de sua prática. Exige por parte do pesquisador e professor considerar os princípios da humildade, da espera, da coerência, do respeito e do desapego.Segundo Fazenda (1999)1 devemos ter humildade em reconhecer que construímos um mundo e não o mundo com o outro; espera significa observar todos os fenômenos que pudermos capturar no tempo e no espaço e, após uma reflexão, agir no momento mais adequado; coerência entre o que pensamos e o que fazemos; respeito por si próprio e pelo outro, por ser diferente de mim, mas que não está necessariamente contra mim; desapego tanto de bens intelectuais quanto de bens materiais significa estar aberto a novas ideias.A postura considerando os cinco princípios da interdisciplinaridade sintetizam este momento histórico nas instituições de ensino, pesquisa e extensão. Professores, pesquisadores estão desafiando e trabalhando com novas metodologias no processo de ensino e aprendizagem e na condução de suas pesquisas que exigem coleta de dados em campo.Convido para submeterem os resultados de pesquisas na Revista Tecnologia e Ambiente para que possamos contribuir na socialização destes resultados.Uma boa leitura!
Effects of varieties and boron on growth and yield of summer tomato
Authors: Sanjida M. , Howlader J. , Akon M. R. , Ahmed T.
Published: November 2020

A study was conducted to investigate the effects of varieties and boron (B) levels on growth and yield of summer tomato (Lycopersicon esculentum Mill.) at the Germplasm Centre in the Department of Horticulture, Patuakhali Science and Technology University, Patuakhali during the period from May, 2018 to September, 2018. Fifteen treatments were comprising (i) three summer tomato varieties (BARI hybrid tomato 4, 8 and 10) and (ii) five levels of boron as boric acid (0, 1, 2, 3 and 5 kg B ha-1) in all combinations. Randomized complete block design with three replications was used in the earthen pot (0.79 ft3) experimentation. The effects of varieties and boron levels showed significant variations (p <0.05) on growth and yield of summer tomato at different days after transplanting. Among the varieties at final count plant-1, delayed flowering (32.6 days), the highest plant height (93.8 cm), number of leaves (99.93), no. of branches (26.27), no. of flower clusters (18.53), no. of flowers (82.73), no. of fruits (51.87), longest fruit length (41.87 mm) and maximum fruit width (48.0 mm), weight of individual fruit (55.71 g) and total weight of fruits (2892.88 g) were observed in BARI hybrid tomato 8. In contrast, the lowest plant height (87.3 cm), no. of leaves (86.47), no. of branches (24.06), no. of flower clusters (15.87), no. of flowers (66.07), no. of fruits (37.33), weight of individual fruit (43.60 g) and total weight of fruits (1630.57 g) were found in BARI hybrid tomato 4; and early flowering (31.93 days), shortest fruit length (33.07 mm) and maximum fruit width (34.60 mm) were noticed in BARI hybrid tomato 10. Among the boron levels at final count plant-1, early flowering (29.67 days), the maximum no. of flower clusters (18.44), no. of flowers (89.11), no. of fruits (46.22) and total weight of fruits (2364.29 g) were recorded in 2 kg B ha-1 treatment; the maximum plant height (96.50 cm), no. of leaves (102.89), no. of branches (28.11), longest fruit length (42.89 mm) and maximum fruit width (46.78 mm) and weight of individual fruit (51.74 g) were obtained in 3 kg B ha-1 treatment. Conversely, delayed flowering (34.67 days), minimum plant height (83.50 cm), no. of leaves (87.56), no. of branches (21.78), no. of flower clusters (15.89), no. of flowers (63.56), no. of fruits (40.33), shortest fruit length (31.78 mm) and minimum fruit width (34.67 mm), weight of individual fruit (47.47 g) and total weight of fruits (1936.00 g) were recorded in control (0 kg B ha-1) treatment. Our results suggest that the inclusion of B (2–3 kg ha-1) with the current fertilization practice will enhance the growth and yield of summer tomato grown at AEZ (agro-ecological zone) 13 while BARI hybrid tomato 8 could be recommended as one of the promising varieties.
Identifying different challenges of online business using document analysis
Authors: Aziz M. N. , Maliha S. R.
Published: November 2020

The main focus of this study was to find out the different online business challenges in different scenarios. Documents analysis was used as the data collection method. This study exhibits a qualitative analysis and includes challenges on different aspects of e-businesses in South Asia and the European Union. The delivery problem, security concern, tax issue, legal issue, technological issue, consumer personality, trust issue, cultural diversity, etc. have been found as the challenges for e-business in South Asia. Different currencies, trust issues, different payment gateways, language issues, tax compliance, different marketing content, increased competition, etc. have been found as the challenges for e-business in the European Union.
Characterization and petal color analysis of Gerbera cultivars
Authors: Jahan M. R. , Shahanaz B. , Islam M. M. , Rakibuzzaman M. , Jamal Uddin A. F. M.
Published: November 2020

Breeders and Researchers need information for selecting and improving gerbera flower as promising cut flowers through flower color analysis. This experiment was accomplished to accurately define the different flower color cultivar and analysis of flower color of gerbera in the Horticulture farm of Sher-e-Bangla Agricultural University during the period of January, 2017 to June, 2017. Fourteen gerbera cultivars were used in this experiment arranged in Randomized Complete Block Design with three replications. The gerbera cultivars have been classified based on peduncle length and diameter, receptacle diameter, ray floret diameter, trans floret diameter, disc diameter, flower head type, disc color, flower shape, flower per plant and floret color following UPOV authorized guidelines. The color of the gerbera cultivars were definitely measured and expressed through L* (lightness), a* and b* (two Cartesian coordinates) including C* and hab (Chroma & Hue angle) based on CIELab scale. Classification and variation in petal color attributes presented in tables and plates that may be used for further research to improve the flower sector.
A conformação das cidades novas planejadas no Brasil do século vinte
Authors: Rego Renato Leão
Published: November 2020

Este artigo analisa as cidades criadas nas frentes pioneiras de colonização agrícola no Brasil do século XX. Como múltiplo estudo de caso, em perspectiva comparativa, são analisados os empreendimentos privados de colonização do norte do Paraná e do norte do Mato Grosso, além da iniciativa estatal na Amazônia, que criaram conjuntos de novas cidades no período entre os anos 1930 e 1970. Apoiada em extensa bibliografia, a análise considera a concretização de ideias urbanísticas em circulação global, as formas urbanas produzidas e seu contexto cultural. Como resultado o trabalho reconhece a transformação física do território atrelada à noção de desenvolvimento das políticas governamentais vigentes; o trabalho remoto dos projetistas das novas cidades como produto de experiências metropolitanas; a adaptação seletiva, a transformação e o hibridismo das ideias urbanísticas incorporadas; o planejamento regional tributário do ideário cidade jardim, com estrutura urbana hierarquizada e configuração de regiões urbanas; a arte urbana como preceito para os projetos desenvolvidos majoritariamente por engenheiros na primeira metade do século em contrapartida à hegemonia da cidade funcional dos arquitetos no período posterior; e, por fim, a prevalência da grelha como padrão de traçado urbano.
In dogs undergoing anaesthesia do pre-anaesthetic gastroprotectants reduce gastro-oesophageal reflux?
Authors: Barry Leanne
Published: November 2020

PICO question

In dogs undergoing anaesthesia do pre-anaesthetic gastroprotectants reduce gastro-oesophageal reflux?

 

Clinical bottom line

Category of research question

Treatment

The number and type of study designs reviewed

Five papers were critically reviewed. There was a randomised prospective study, two randomised blinded prospective studies, randomised non-blinded prospective study and a randomised, double blinded and placebo-controlled prospective study.

Strength of evidence

Moderate

Outcomes reported

Evidence of high quality suggests omeprazole or cisapride with esomeprazole decrease the incidence of gastro-oesophageal reflux (GOR) in the anaesthetised dog. In addition, a study of lower quality showed that continuous infusion of metoclopramide at a higher than normal dose rate decreased the incidence of GOR.

Conclusion

Omeprazole or cisapride with esomeprazole decreases the incidence of GOR in the anaesthetised dog.

 

How to apply this evidence in practice

The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.

Knowledge Summaries are a resource to help reinforce or inform decision-making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care
Sistema de Control Interno basado en el modelo COSO 2013 y su impacto en la Gestión Empresarial en las empresas del sector construcción de edificios, en el distrito de El Agustino, año 2018
Authors:   ,   Universidad Peruana de Ciencias Aplicadas (UPC), Centeno Vilchez Hugo Junior , Zavaleta De la cruz Jorge Alan
Published: November 2020

La presente investigación tiene como objetivo determinar el impacto del Sistema de Control Interno basado en el modelo COSO 2013 respecto a la Gestión Empresarial en las empresas de sector construcción de edificios en el distrito de El Agustino, año 2018. Para determinar el impacto, es preciso validar las pruebas de hipótesis, realizar análisis de consistencia estadística, entre otros estudios que finalmente permitan producir resultados y conclusiones de la investigación. La tesis inicia con la introducción, posteriormente se desarrolla a través de los siguientes cinco capítulos: Capítulo I - Marco Teórico, se desarrolla las principales definiciones, importancia, evolución, entre otros relacionados con el marco teórico de las variables de estudio; asimismo, un análisis de la relación entre las dos variables y del sector construcción. Capitulo II – Plan de Investigación, se presenta a nivel general y específicas, los problemas, objetivos e hipótesis; además, se establece la metodología a utilizarse para el desarrollo de la investigación. Capitulo III – Metodología de la Investigación, se define la población y muestra para el desarrollo de la investigación cuantitativa y cualitativa. Capitulo IV - Desarrollo de la Investigación, se ejecuta las encuestas y entrevistas en profundidad, desarrollando también el caso práctico para aplicar el sistema de control interno y su influencia en una empresa del sector de construcción de edificios. Capítulo V - Análisis de los Resultados, se realiza el análisis de los instrumentos y del caso práctico, y la validación de las hipótesis. Finalmente, se realiza las conclusiones y recomendaciones de la presente investigación.
STEPPING OUT OF THE “ENCLAVE”: PUBLIC ACTIVITIES OF THE SERBIAN ORTHODOX CHURCH AND THE QUEST TO REGAIN SOCIAL AUTHORITY IN THE 1980S
Authors: VESIĆ IVANA , PENO VESNA
Published: November 2020

In this paper we will consider how, from the beginning to the end of the 1980s, the Serbian Orthodox Church gradually abandoned its restricted mode of public action and moved from an enclave form, with occasional elements of counterpublics, to a dominant public sphere. This process was the result of a complex set of phenomena that often overlapped. Pressure from authorities on religious communities and believers started to decline at the time despite restrictive legislation regarding public appearances by religious officials still being in force. This was followed by a pronounced deatheization of younger parts of the population and an expansion of various forms of secular religiosity (popular culture, sports), including hybrid types of postmodern spirituality within Yugoslav society. In such circumstances, religious communities were encouraged to expand the scope of their public activities, so they found new forms of communication and networking, both among believers and in various social circles. Our aim is to point to forms of public action cultivated at the time by the Church and the stages it underwent in its participation in the public sphere. Additionally, the factors that influenced a change in the Church’s public and social position in the late 1980s will be discussed, along with the consequences caused in different areas of its functioning.
NEW MORPHOLOGICAL OBSERVATIONS ON PRATYLENCHUS THORNEI SHER & ALLEN, 1953 (NEMATODA PRATYLENCHIDAE) BASED ON THE POPULATION FROM IRAN
Authors: MOVAHEDIFAR EBRAHIM , AZIMI SEDIGHE
Published: November 2020

A population of Pratylenchus thornei was recovered from the rhizospheric soil of sugarcane in Khuzestan province, southwest Iran. It was studied using morphological and molecular data and new morphological observations were made. This population is characterized by 457-551 μm long females, lateral field with five or six smooth incisures, lip region with three annuli, stylet 14.0-16.8 μm long with rounded basal knobs, spermatheca empty, tail subcylindrical and slightly conical towards tip, tail terminus truncate, subdigitate, trilobed or indented. Comparisons with some previously reported populations and similar species are discussed. This is the first report of the species from sugarcane fields in Iran. The molecular phylogenetic analyses were done by using partial sequences of the D2-D3 expansion segments of large subunit, and internal transcribed spacer (LSU D2-D3 and ITS rDNA) regions. The studied population of the species formed a maximally supported clade with other sequences of the species in both phylogenetic analyses using Bayesian inference
A study of admissions to a PICU in a Trust that has undergone significant bed closures and other service re-design
Authors: Cunningham Rebecca , Kranidiotis Laki , Walker Tara
Published: November 2020

Background: Psychiatric intensive care units (PICU) have policies based on the National Minimum Standards (NAPICU) which are adhered to with varying rigour, and this became particularly apparent following the closure of beds in a Trust. Around this time, other service changes
also took place: the development of an Admission Ward and a Treatment Ward, and a change in the function of the Community Mental Health Teams.
 Aims: The pattern of admissions to the Trust's PICU altered, and the study aimed to confirm and characterise these changes. An association
with the closure of a 20 bed general adult psychiatric ward was observed, and the study examined the pattern of admissions before and after this date, believing that the findings may inform local service planning, and be of interest to other services.
 Method: This naturalistic
study examined the records of the 245 patients admitted in the year preceding the bed closures and the two following years. Objective information was gathered for analysis.
 Results: Following the bed closures there was an increase in the number of admissions, an increase
in unplanned admissions not meeting the admission criteria for a PICU and an increase in patients discharged directly home. A 'lag' period was also evident before these changes became more apparent. These findings were statistically significant.
 Conclusions: The study found
a changed pattern of admissions at the time of bed closures and other service developments. PICU admissions can be a useful barometer of the performance of a wider service.
Case Report Leucocytozoonosis pada Kalkun (Meleagris gallopavo)
Authors: Yesica Reza
Published: November 2020

ABSTRAKLeucocytozoon adalah parasite genus protozoa yang termasuk dalam filum Apicomplexa yang menginfeksi species unggas. Leucocytozoonosis merupakan salah satu penyakit yang masih sering muncul pada ayam. Angka kematian pada ayam pedaging bisa mencapai 40%. Meskipun kasus penyakit ini lebih banyak ditemukan di peternakan ayam pedaging, bukan berarti ayam petelur dan kalkun dapat lolos dari infeksi parasit ini. Kasus Leucocytozoonosis pada ayam petelur dan kalkun jarang terjadi, namun jika Leucocytozoonosis menyerang, angka kematian bisa mencapai 30%. Hal tersebut juga menyebabkan peningkatan nilai FCR (Feed Conversion Ratio) dan penurunan produksi telur. Dalam penelitian ini diambil sampel darah dari kalkun betina berumur 2 tahun. Hasil pemeriksaan menunjukkan bahwa kalkun terinfeksi protozoa Leucocytozoon sp. Pengobatan pada unggas dapat dilakukan dengan pemberian chloroquine, trimethoprim, sulphaquinoxaline, dan primaquine serta menjaga kebersihan kandang.
Human-Like Arm Motion Generation: A Review
Authors: Gulletta Gianpaolo , Erlhagen Wolfram , Bicho Estela
Published: November 2020

In the last decade, the objectives outlined by the needs of personal robotics have led to the rise of new biologically-inspired techniques for arm motion planning. This paper presents a literature review of the most recent research on the generation of human-like arm movements in humanoid and manipulation robotic systems. Search methods and inclusion criteria are described. The studies are analysed taking into consideration the sources of publication, the experimental settings, the type of movements, the technical approach, and the human motor principles that have been used to inspire and assess human-likeness. Results show that there is a strong focus on the generation of single-arm reaching movements and biomimetic-based methods. However, there has been poor attention to manipulation, obstacle-avoidance mechanisms, and dual-arm motion generation. For these reasons, human-like arm motion generation may not fully respect human behavioural and neurological key features and may result restricted to specific tasks of human-robot interaction. Limitations and challenges are discussed to provide meaningful directions for future investigations.
Bariatric Surgery: Preoperative Assessment
Authors: El-Shareif Hawa Juma
Published: November 2020

Obesity is associated with increased morbidity and mortality and impaired quality of life. Weight losse is associated with improvement or even cure of cardiovascular risk factors with cardiometabolic benefit. nonsurgical measures for weight loss is rarely successful in the long term. Bariatric surgery has achieved clear success in reversing the abnormal metabolic profile associated with obesity. Pre surgical evaluation is important to rule out any medical or psychological problems that increased the surgical mortality or adversely affect the outcome.
Linear Regression Analysis for Time-Point Datasets
Authors: Patil Janardan , Len Li , Bharat Abhinav , Li Xi
Published: November 2020

In this paper, we present a relapse based demonstrating way to deal with investigate various arrangement MTC information. A commonplace use of this displaying approach incorporates three stages: first, define a model that approximates the connection between quality articulation and trial factors, with boundaries consolidated to address the exploration premium; second, utilize least-squares and assessing condition methods to gauge boundaries and their relating standard blunders; third, register test insights, P-qualities and NFD as proportions of factual criticalness. The benefits of this methodology are as per the following. To begin with, it tends to the exploration interest in a particular, precise way, and maximally uses all the information and other important data. Second, it represents both orderly and irregular varieties related with the information, and the consequences of such examination give not just quality explicit data applicable to the exploration objective, yet additionally its dependability, in this way helping agents to settle on better choices for subsequent investigations. Third, this methodology is truly adaptable, and can undoubtedly be stretched out to different sorts of MTC considers or other microarray explores by detailing various models dependent on the test plan of the investigations.
Writing Africa, Righting America: An Experience of Otherness in J. P. Clark's America, their America
Authors: Ayodeji Adewuyi
Published: November 2020

Considered one of the finest first-generation Nigerian writers, John Pepper Clark-Bekederemo, who passed away on 13th October, 2020, had been categorised as a Eurocentric writer. This work assesses the authenticity or otherwise of this critics’ perception of Clark by critiquing his America, their America. By analysing this autobiography vis-à-vis the notion of self and other which is a theoretical concern in contemporary travel writing, it was established, among other things, that every culture has its dark sides which it must not feel too proud to change as time and situation demand; that Clark vehemently rejects the Americans’ claim of sophistication and superiority of their culture over African culture. The paper concludes that contemporary travel writing should be a rightful site for negotiating cultural, political and diplomatic compromises between the Self and the Other since the gulf may be difficult to close altogether.
Atividades Pedagógicas Não Presenciais
Authors: Neves Julianne , Pinto Leandro Rafael , Cezimbra Letícia Aparecida Gomes , Rosário Renato
Published: November 2020

A interdisciplinaridade tem muitos conceitos e variados enfoques no ambiente escolar e, embora esteja presente nos discursos de diversos educadores e instituições de ensino, ainda apresenta desafios nas possíveis formas de sua aplicação. Assim, este artigo apresenta alguns conceitos de interdisciplinaridade defendidos por autores de referência da educação, da ciência e do ensino, que estão relacionados à prática docente e à importância de sua utilização, em especial para o constante aprimoramento da Educação Profissional e Tecnológica no Brasil. O objetivo principal deste trabalho foi realizar uma análise destas teorias e conceitos com as propostas interdisciplinares aplicadas nas Atividades Pedagógicas Não Presenciais (APNP) dos cursos Técnicos Integrados ao Ensino Médio do Campus Curitiba do IFPR neste período de pandemia da Covid-19. Para fundamentar a temática foram utilizados como métodos, a pesquisa bibliográfica e documental e para a análise de dados, utilizou-se a análise de conteúdo em uma abordagem qualitativa. Foram encontradas três propostas interdisciplinares ocorridas entre os meses de março a maio de 2020, foram contactados os autores destas propostas e entrevistados, por e-mails ou videoconferência, para obter o detalhamento de cada uma bem como uma prévia dos resultados obtidos pelos professores responsáveis. Finalmente, comprovou-se que, apesar de distintas, as três propostas analisadas são exemplos significativos de experiências interdisciplinares, cujos planejamentos foram baseados no diálogo, nas relações e cooperação entre professores e estudantes e na desconstrução da prática docente habitual.
The effect of anti-cancer and anti-tuberculosis treatments in lung cancer patients with active tuberculosis: a retrospective analysis
Authors: CHAI MEI , Shi Qingming
Published: November 2020

BackgroundLung tuberculosis (TB) and lung cancer have a complex relationship. Data concerning TB treatment in lung cancer patients are still incomplete. The aim of this study was to investigate the effects of anti-cancer and anti-tuberculosis treatments in lung cancer patients with active lung TB.MethodsIn a retrospective cohort study, lung cancer patients with active lung TB were identified between January 2013 and December 2016. Age- and sex-matched lung cancer patients without tuberculosis were selected as control subjects. Anti-cancer and anti-tuberculosis treatments were administered according to the national guidelines. The clinical courses and responses of lung cancer patients with and without active lung TB were examined and compared.ResultsA total of 31 consecutive lung cancer patients were diagnosed with active lung TB. Fifty-one lung cancer patients without TB were enrolled as control subjects. Most patients in the two groups were elderly, had advanced non-small cell lung cancer and had tumor burdens. The anti-cancer treatment completion rate and response rate were not different between two group (87.1% in TB treatment patients vs. 92.2% in lung cancer patients; 77.4% in TB treatment patients vs. 88.2% in lung cancer patients, respectively). The anti-tuberculosis treatment completion rate and success rate was 87.1% and 80.7%. The median survival times were not different between two groups (52 weeks in TB treatment patients vs. 57 weeks in lung cancer patients). The change in Karnofsky performance score was also not different between two groups. The most common side effect in TB treatment patients was liver injury (61.3%). The most serious side effect in TB treatment patients was leukocyte deficiency (9.7% in Grade 3). Both of side effects mentioned above were not different between two groups.ConclusionBoth anti-cancer and anti-tuberculosis treatments can be safely and effectively administered in lung cancer patients with active lung TB. Attention should be paid to the risk of tuberculosis in lung cancer patients in TB high-burden countries.
Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: A meta-analysis based on 24 studies
Authors: Imani Danyal , Eslami Mohammad Masoud , Sarab Gholamreza Anani , Aliyu Mansur , Razi Bahman , Rezaei Ramazan
Published: November 2020

Background: Previous studies evaluated the association of IL-4 C33T polymorphism and risk of bronchial asthma but failed to establish a consistent conclusive association. In the present meta-analysis, we intend to define a more reliable estimate of the association in the presence of filling published literature.Methods: An exhaustive search in Web of Science, Scopus, and PubMed databases was performed to identify all relevant publications before September 2020, and 24 publications (28 studies) with 6587 cases and 8408 controls were included in final analysis. The association between polymorphism and risk of asthma were measured by Odd ratios (ORs) and 95% confidence intervals (CIs). Moreover, Cochran's Q and the I2 statistics were used to evaluate the degree of heterogeneity between studiesResults: In the overall study populations, a significant positive association was detected under all genotype models and announced the IL-4 C33T polymorphism as a potential risk factor in the pathogenesis of asthma. In the subgroup analysis by age, a significant association between IL-4 C33T polymorphism and risk of asthma in different age groups was identified in allelic model, which highlighted the predisposing role of the T allele for the asthma risk in all three age groups. Furthermore, the results of subgroup analysis by continent were heterogenous. Accordingly, IL-4 C33T polymorphism was a risk factor in Europeans (all models except heterozygote comparison), Americans (all models except recessive and homozygote comparison) and Asians (just recessive and allelic model). Finally, the ethnicity-specific analysis disclosed a significant association between IL-4 C33T polymorphism and asthma risk in Caucasians (all genotype models except heterozygote comparison), while this association was not significant in African-Americans.Conclusions: This study suggests that IL-4 C33T polymorphism potentially acts as a risk factor for asthma in different ethnicities and age groups.
Feature-driven classification reveals potential comorbid subtypes within childhood apraxia of speech
Authors: Stein Catherine , Benchek Penelope , Miller Gabrielle , Hall Noémi B. , Menon Dhanya , Freebairn Lisa , Tag Jessica , Vick Jennell , Taylor H. Gerry , Lewis Barbara A. , Iyengar Sudha K.
Published: November 2020

Background: Childhood apraxia of speech (CAS) is a neurodevelopmental disorder with heterogeneous communication and other comorbid manifestations. While previous studies have characterized speech deficits associated with CAS, few studies have examined variability in reading and language and/or other developmental comorbidities. We sought to identify comorbid subgroups within CAS that could be clinically relevant as well as genetically distinctive. Methods: In a group of 31 children with CAS and 8 controls, we performed hierarchical cluster analysis utilizing measures of articulation, vocabulary, and reading. We also conducted a chart review of the children with CAS to examine other clinical characteristics in these children and their association with subgroup membership. Results: We identified 3 comorbid subgroups within CAS of varying severity. The high severity subgroup was characterized by poor reading and vocabulary, and the moderate severity subgroup by poor reading and non-word repetition but average vocabulary, compared to the mild severity subgroup. Subgroups were indistinguishable with respect to speech sound production, the hallmark of CAS, all demonstrating poor articulation. Children in the most severe subgroup were more likely to have early problems feeding (p=0.036). Conclusions: Children with CAS may potentially be classified into comorbidity groups based on performance on vocabulary and reading measures, providing additional insight into the heterogeneity within CAS with implications for educational interventions.
Altered Tyrosine Phosphorylation of Cardiac Proteins Prompts Contractile Dysfunction in Hypertrophic Cardiomyopathy
Authors: Xu Mingguo , Bermea Kevin , Ayati Marzieh , Yang Xiaomei , Fu Zongming , Heravi Amir , Zhang Xinyou , Na Chan-Hyun , Everett Allen , Gabrielson kathleen , Foster D Brian , Paolocci Nazareno , Murphy Anne Margaret , Ramirez-Correa Genaro
Published: November 2020

Altered Serine/Threonine phosphorylation of the cardiac proteome is an established hallmark of heart failure (HF). However, the contribution of tyrosine phosphorylation to the pathogenesis of these diseases remains unclear. The cardiac proteome was explored by global mapping to discover and quantify site-specific tyrosine phosphorylation in two cardiac hypertrophic models; cardiac overexpression of ErbB2 (TgErbB2) and cardiac expression of α-Myosin heavy chain R403Q (R403Q-αMyHCTg) compared to control hearts. Phosphoproteomic changes found in R403Q-αMyHC Tg mice indicated EGFR1, Focal Adhesion, VEGF, ErbB signaling, and Chemokine signaling pathways activity were likely to be activated. On the other hand, TgErbB2 mice findings displayed significant overrepresentation of Right Ventricular Cardiomyopathy, Hypertrophic Cardiomyopathy (HCM), and dilated cardiomyopathy (DCM) KEGG Pathways. In silico kinase-substrate enrichment analysis (KSEA) highlighted a marked downregulation of canonical MAPK Pathway Activity downstream of k-Ras in TgErbB2 mice and activation of EGFR, PP2 inhibition of c-Src, and Hepatocyte growth factor stimulation. In vivo ErbB2 inhibition by AG-825 decreased cardiac fibrosis, cardiomyocyte disarray, and rescued contractile function on TgErbB2 mice. These results suggest that altered tyrosine phosphorylation may play a regulatory role in cardiac hypertrophic models, suggesting that tyrosine kinase inhibitors could be used therapeutically in Hypertrophic Cardiomyopathy.
Accessing the Frank-Kasper Phase of Block Copolymer in the Fuzzy Colloid Regime
Authors: Chen Hsin-Lung , Nouri Babak , Chen Chun-Yu , Huang Yu-Shan , Mansel Bradley
Published: November 2020

The discovery of Frank-Kasper (FK) phase in block copolymer (bcp) has prompted the progress of the field of soft quasicrystals. In principle, the formation of FK phase from the supercooled liquid phase of the bcp micelles should involve the mass transport of constituent molecules to transform the unimodal distribution of micelle size into the multimodal distribution prescribed by the volume asymmetry of the Voronoi cells in the FK phase. Here we present a new regime in which the Laves C14 phase of bcp developed below the glass transition temperature of the micelle core, where the mass transport was inhibited by the immobile block chains forming the core. The bcp micelle comprising a glassy core and a soft corona resembles the fuzzy colloid and the strong van der Waals attraction between the cores directs their organization into C14 phase to minimize the interparticle interaction energy under the metastable condition.
MUC4 mutation correlates with tumor mutation burden and the immune microenvironment in colorectal cancer
Authors: Li Ting , Hui Wenjia , Halike Halina , Gao Feng
Published: November 2020

Background: Immunotherapy is a new strategy for Colorectal cancer (CRC) treatment. Tumor mutation burden (TMB) may act as an emerging biomarker for predicting responses to immunotherapy. Nevertheless, no studies investigate if these gene mutations correlate to TMB and tumor-infiltrating immune cells. Methods: Somatic mutation data for CRC samples were obtained from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) datasets. Then, we investigated the relationship between these mutant genes, TMB and overall survival outcomes. GSEA analysis was performed to explore the underlying mechanism of mutant gene. Finally, we further verified the connection between gene mutations and immune response.Results: We identified 17 common mutant genes shared by both two cohorts. Further analysis found that MUC4 mutation was strongly related to higher TMB and predicted a poorer prognosis. Moreover, functional enrichment analysis of samples with MUC4 mutation revealed that they were involved in regulating the natural killer cell mediated cytotoxicity signaling pathway. Significant changes in the proportion of the immune cells of CD8 T cells, activated NK cells, M1 macrophages and resting memory CD4 T cells were observed using the CIBERSORT algorithm. Conclusions: Our research revealed that MUC4 mutation significantly correlated with increased TMB, a worse prognosis and modulating the immune microenvironment, which may be considered a biomarker to predict the outcome of the immune response in colorectal cancer.
Non-Invasive Plasma Glycomic and Metabolic Biomarkers of Post-treatment Control of HIV
Authors: Giron Leila , Palmer Clovis , Liu Qin , Yin Xiangfan , Papasavvas Emmanouil , Damra Mohammad , Goldman Aaron , Tang Hsin-Yao , Johnston Rowena , Mounzer Karam Mounzer , Kostman Jay , Tebas Pablo , Landay Alan , Montaner Luis , Jacobson Jeffrey , Li Jonathan , Abdel-Mohsen Mohamed
Published: November 2020

Non-invasive biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption are urgently needed. Such biomarkers can improve the safety of analytic treatment interruption (ATI) and provide mechanistic insights into the pathways involved in post-ART HIV control. We identified plasma glycomic and metabolic signatures of time-to-viral-rebound and probability-of-viral-rebound using samples from two independent cohorts. These samples include a large number of post-treatment controllers, a rare population demonstrating sustained virologic suppression after ART-cessation. The signatures remained significant after adjusting for key demographic and clinical confounders. We also confirmed a mechanistic link between biomarkers and HIV latency reactivation and myeloid inflammation in vitro. Finally, machine learning algorithms selected sets of biomarkers that predict time-to-viral-rebound with 74–76% capacity and probability-of-viral-rebound with 97.5% capacity. In summary, we fill a major gap in HIV cure research by identifying non-invasive biomarkers, with potential functional significance, that predict duration and probability of viral remission after treatment interruption.
Acceptance of Illness, Quality of Life and Nutritional Status of Patients After Lower Limb Amputation Due to Diabetes Mellitus
Authors: Juzwiszyn Jan , Łabuń Adrianna , Tański Wojciech , Szymanska-Chabowska Anna , Zielińska Dorota , Chabowski Mariusz
Published: November 2020

Introduction. Diabetes mellitus is one of the most common chronic diseases with a high number of sufferers worldwide. Diabetic neuropathy and diabetic angiopathy lead to serious infectious complications which are very difficult to combat and may finally lead to the amputation of a lower limb. The aim of the study was to evaluate the quality of life, the level of acceptance of the illness and the nutritional status of patients after lower limb amputation due to diabetes. Methods. Ninety nine patients (23 men and 76 women) were enrolled into the study. They had all undergone lower limb amputation due to diabetic foot and were treated in the Department of General and Oncological Surgery. The following questionnaires were used: the WHO Quality of Life-BREF (WHOQOL–BREF), the Mini Nutritional Assessment (MNA), the Acceptance of Illness Scale (AIS) and the anonymous specific socio-demographic characteristics questionnaire.Results: The diabetes-related amputees were revealed to have a higher QoL within the social domain (mean score 64.48), an intermediate QoL – within the environmental domain (mean score 63.04) and the mental domain (mean score 59.61), and a lower QoL – within physical (somatic) domain (mean score 54.69). There was no statistical correlation between genders or between all the domains of QoL (p>0.05). The mean MNA score was 22.66, which means that patients were at risk of malnutrition. There were statistical differences between women and men as regards nutritional status (p=0.034). The mean AIS score was 27.65 (27.09 women and 29.48 men), which means that the respondents accept their disease. There was no statistical correlation between gender and the acceptance of the disease (p=0.288). There was not statistical correlation between age and QoL (p>0.05). There were statistical differences between age and nutritional status (p<0.05), and between age and acceptance of the illness (p=0.044).Conclusions: The better the quality of life was in all the domains, the better the level of acceptance of illness was. The less malnourished the patient was, the better their quality of life was in all the domains.
Real-World Experience Using the IUB Ballerine MIDI Copper IUD: A Multicenter, Multinational Observational Study
Authors: Yaron Michal , Baram Ilan , Peled Zvi
Published: November 2020

Objective: The aim of the study was to assess efficacy, safety and patient acceptability of the intrauterine ball (IUB) Ballerine MIDI copper intrauterine device (IUD), using real-world data collected from users and physicians.Study design: Retrospective analysis of two cross-sectional survey studies conducted in seven private clinics in Israel or Switzerland, and in one Swiss hospital between January and October 2018. Participants were healthy women who had the non-hormonal IUB Ballerine MIDI inserted >12 months before enrolment. In total, 382 participants and their 19 physicians completed questionnaires relating to device insertion, user experience and performance.Results: Mean age at insertion was 31.8±7.1 years, the survey was answered 16.0±4.7 months following IUB insertion. Most women were married (56.8%) and multigravid (83.5%). In 20 (5.2%) cases premature removal was due to desire to conceive. Excluding these women, the >12-month continuation rate was 71%. The expulsion rate was 17 (4.5%) and pregnancy rate was 4 (1.1%). The IUB was associated with high tolerability, 31% of current users reported no menstrual cramps/pain or light (34%) to moderate (20%) dysmenorrhea. The majority of women (69%) reported moderate to high satisfaction with the device, and 79% said they would recommend it to friends and relatives. Physicians reported in 87% of procedures the device was simple to deploy, with no difficulties encountered.Conclusions: The IUB Ballerine MIDI was demonstrated to be safe, effective and highly accepted in a cohort of women in different clinical settings and among a socioeconomically and demographically diverse population of contraception seekers.
Therapy with of RCHOP-14 Versus RCHOP-21 for People With Aggressive or Advanced Stage Indolent B-Cell Non-Hodgkins Lymphoma: A Systematic Review and Meta-Analysis
Authors: He Yue , Tao Wenqiang , Ji Dexiang , Lu Wei , Xiong Yu , chen Guoan
Published: November 2020

Background: With the advent of rituximab, RCHOP is considered the appropriate chemotherapy for aggressive or advanced stage indolent B-cell Non-Hodgkins Lymphoma(NHL). RCHOP-14 seems to achieve better outcomes than RCHOP -21 in aggressive or advanced stage indolent B-cell NHL patients in recent years.Methods: To verify the befitting chemotherapy regimens for B-cell NHL patients, we searched the electronic databases for relevant English-language literature published through January 2020. The primary outcomes were complete response(CR),progression-free survival (PFS), overall survival(OS), and Adverse events (AEs). Six eligible Phase II and III clinical randomized controlled trials (RCTs) and two high-quality observational comparative studies (OCSs)were extracted, and 5565 B-cell NHL patients involved in evaluable.Results: The analysis demonstrated no significant difference for CR rate (OR= 0.98,95%CI 0.77-1.24，P=0.85)between RCHOP-14 and RCHOP-21. Compared with RCHOP-21, the merged hazard ratio (HR) for PFS and OS was, respectively, 0.94 (95% CI: 0.84-1.06, P=0.32) and 0.91(95% CI: 0.83-1.01, P= 0.08) after treatment with RCHOP-14.A subgroup analysis based on the international prognostic index(IPI) score showed that both chemotherapy regimens were applicable in B-cell NHL patients with different prognosis. The frequency of toxic side-effects was similar between schemes.Conclusions: Therefore, the data presented suggest that the efficacy and safety of both regimens are comparable and that R-CHOP14 remains a viable plan in B-cell NHL patients who prefer a shorter therapy course.
Prognostic value of biglycan in gastric cancer
Authors: Hu Sizhe , Li Peipei , Wang Chenying , Liu Xiyong
Published: November 2020

Background: BGN (biglycan) is a family member of small leucine-rich repeat proteoglycans. High expression of BGN might enhance the invasion and metastasis in some types of tumors. Here, the prognostic significance of BGN was evaluated in gastric cancer.Material and Methods: Two independent Gene Expression Omnibus (GEO) gastric cancer microarray datasets( n= 64, n=432) were collected for this study. Kaplan-Meier analysis was applied to evaluate if BGN impacts the outcomes of gastric cancer. The gene set enrichment analysis (GSEA) was used to explore BGN and cancer-related gene signatures. Bioinformatic analysis predicted the putative transcription factors of BGN.Results: For gastric cancer, the mRNA expression level of BGN in tumor tissues was significantly higher than that in normal tissues. Kaplan-Meier analysis showed that higher expression of BGN mRNA was significantly associated with more reduced recurrence-free survival (RFS). GSEA results suggested that BGN significantly enriched metastasis and poor prognosis gene signatures, revealing that BGN might be associated with cell proliferation, poor differentiation, high invasiveness of gastric cancer. Meanwhile, the putative transcription factors, including AR, E2F1, and TCF4, weres predicted by bioinformatic analysis and also significantly correlated with expression of BGN in mRNA levels. Conclusion: High expression of BGN mRNA was significantly related to poor prognosis, which suggested BGN was a potential prognostic biomarker and therapeutic target of gastric cancer.