bluuebunny/crossref_metadata_2025 huggingface dataset:
Moral Responsibility, Shared Values, and Corporate Culture
Authors: Dempsey James
Published: November 2015

Although it is unremarkable to hear a corporate culture described as ethical or unethical, it remains quite unclear what such a claim means or how it may be justified. I begin by addressing these two questions by offering an account of corporate culture as the intrinsic values that are shared by organisation members and that underpin organisational goals. I then employ this analysis to offer a new account of how moral responsibility is generated and distributed in business organisations. Since certain corporate values, or culture, will predictably promote wrongdoing by members, all those who participated in that culture will acquire a degree of moral responsibility for the wrongdoing that results. They are, we may say, complicit in the wrongdoing because they helped facilitate it. This is because, by sharing values in the way that creates corporate culture, organisation members give each other reasons for acting in line with those values.
The Inter-Institutional Interface of Religion and Business
Authors: Peifer Jared L.
Published: November 2015

It is frequently asserted that religion enhances the ethical climate of business. This is buttressed by the tacit assumption that religious moral authority is easily combined with and exerted in business, an inter-institutional process I call Engagement. By drawing upon Secularization Theory’s societal-level focus on religious authority and the symbolic boundary work surrounding the interface of competing institutional logics, I theorize a broader range of inter-institutional processes including, Disengagement, Co-optation and Adjudication. To exemplify these inter-institutional processes, I engage in qualitative analysis of historic religious magazines from 1927-1931 and 1985-1989 and focus on the religious moral authority directed at the financial market. I discuss how my findings relate to the scholarship on Religion and Business in particular and Business Ethics more broadly.
New Electromagnetic Design of Miniature AF VCM Actuator with Low Cost
Authors: Liu C.-S. , Kuo L. , Tsai B.-J.
Published: November 2015

Recently, compact and high-resolution camera modules with auto-focusing (AF) function have been integrated into cell phones in order to capture sharp photographs. Consumer demands AF camera modules in cell phones to have high performance with low cost. Accordingly, the present study proposes a new electromagnetic design of miniature AF voice coil motor (VCM) actuator with closed-loop control for cell phone camera modules to satisfy the requirements. The structure of the proposed AF VCM actuators was designed by using simulation methods. The performance of the proposed AF VCM actuators was demonstrated by a laboratory-built prototype. The experimental results have shown that the proposed AF VCM actuator has excellent performance with lower power consumption, higher positioning repeatability, and lower cost, when compared to previous AF VCM actuators with open-loop control or closed-loop control.
A Note on the Overall Magnification of a Gravitational Point-Source—Point-Lens System
Authors: Walters S. J. , Forbes L. K.
Published: November 2015

The total magnification due to a point lens has been of particular interest as the theorem that gravitational lensing results in light amplification for all observers appears to contradict the conservation of photon number. This has been discussed several times, and various resolutions have been offered. In this note, we use a kinematic approach to provide a formula for the magnification factor for the primary image accurate to first order and valid for rays leaving the source at any trajectory. We thus determine the magnification over a sphere surrounding the system. A new result found is that while the magnification dips below unity far from the optical axis as noted by others, it returns to unity directly behind the source.
Social Practice of a Career Guidance Project Based on the Wisdom of the Classic of Changes
Authors: Liu Shu-Hui , Lu Yi-Jen , Deng Chi-Ping , Wang Chih-Hung , Keh Foo Bee , Tsai Ya-Chi
Published: November 2015

The Virtue Existential Career Model (VEC) is a Chinese career development model based on the Classic of Changes. It is designed to supplement the person-environment fit paradigm of Taiwan's 12-Year Basic Education for junior high school students. We adopted an action research approach with two parts, reflection-on-action and critical-emancipatory. An easy-to-use VEC career curriculum and a career information system (Career Genesis; CG) were developed by a team of staff members from government agencies (Tainan Department of Education and Student Counseling Centers), junior high schools, and the Chinese Career Research Center of National Changhua University of Education, Taiwan. The outcome of this project was strong on fostering interconnectedness. Implementing our VEC curriculum and CG to 30 junior high school students received statistically significant immediate increases in resilience, adaptation, and liking of career decision. The feedback and reflections suggest that mandating, attracting, and simplifying are useful strategies to promote our VEC model as well as to facilitate social change and create a multiple-win situation for all parties involved. This approach also follows the tao (道) of the Classic of Changes to provide new knowledge.
Effect of dietary protein on plasma insulin-like growth factor-1, growth, and body composition in healthy term infants: a randomised, double-blind, controlled trial (Early Protein and Obesity in Childhood (EPOCH) study)
Authors: Putet Guy , Labaune Jean-Marc , Mace Katherine , Steenhout Philippe , Grathwohl Dominik , Raverot Veronique , Morel Yves , Picaud Jean-Charles
Published: November 2015

The effect of protein intake on growth velocity in infancy may be mediated by insulin-like growth factor-1 (IGF-1). This study aimed to determine the effects of formulae containing 1·8 (F1·8) or 2·7 g (F2·7) protein/418·4 kJ (100 kcal) on IGF-1 concentrations and growth. Healthy term infants were randomly assigned to receive F1·8 (n74) or F2·7 (n80) exclusively for the first 4 months of life. A group of breast-fed infants (n84) was followed-up simultaneously (reference). Growth and body composition were measured at 0·5, 4, 6, 12, 36, 48 and 60 months of life. The IGF-1 concentrations at 4 months (primary outcome) were similar in the F1·8 (67·1 (sd20·8) ng/l;n70) and F2·7 (71·2 (sd27·5) ng/l;n73) groups (P=0·52). Both formula groups had higher IGF-1 concentrations than the breast-fed group at 4 and 9 months of age (P≤0·0001). During the first 60 months of life, anthropometric parameters in the F1·8 group were lower compared with the F2·7 group, and the differences were significant for head circumference from 2 to 60 months, body weight at 4 and 6 months and length at 9, 12 and 36 months of age. There were no significant differences in body composition between these two groups at any age. We conclude that, in formula-fed infants, although increased protein intake did not affect the IGF-1 concentration during the first 12 months of life, it did affect length and head circumference growth, suggesting that factors other than IGF-1 could play roles in determining growth velocity.
Non-pest prey do not disrupt aphid predation by a web-building spider
Authors: Welch K.D. , Whitney T.D. , Harwood J.D.
Published: November 2015

A generalist predator's ability to contribute to biological control is influenced by the decisions it makes during foraging. Predators often use flexible foraging tactics, which allows them to pursue specific types of prey at the cost of reducing the likelihood of capturing other types of prey. When a pest insect has low nutritional quality or palatability for a predator, the predator is likely to reject that prey in favour of pursuing alternative, non-pest prey. This is often thought to limit the effectiveness of generalist predators in consuming aphids, which are of low nutritional quality for many generalist predators. Here, we report behavioural assays that test the hypothesis that the generalist predator, Grammonota inornata (Araneae: Linyphiidae), preferentially forages for a non-pest prey with high nutritional quality (springtails), and rejects a pest prey with low nutritional quality (aphids). In no-choice assays, molecular gut-content analysis revealed that spiders continued to feed on the low-quality aphids at high rates, even when high-quality springtails were readily available. When provided a choice between aphids and springtails in two-way choice tests, spiders did not show the expected preference for springtails. Decision-making by spiders during foraging therefore appears to be sub-optimal, possibly because of attraction to the less frequently encountered of two preys as part of a dietary diversification strategy. These results indicate that behavioural preferences alone do not necessarily compromise the pest-suppression capacity of natural enemies: even nutritionally sub-optimal pest prey can potentially be subject to predation and suppression by natural enemies.
Why are ototopical aminoglycosides still first-line therapy for chronic suppurative otitis media? A systematic review and discussion of aminoglycosides versus quinolones
Authors: Harris A S , Elhassan H A , Flook E P
Published: November 2015

Objective:

This systematic review aimed to establish that quinolones are as effective as aminoglycosides when used to treat chronic suppurative otitis media.

Method:

The review included good quality, randomised, controlled trials on human subjects, published in English, that compared topical aminoglycosides with topical quinolones for the treatment of chronic suppurative otitis media.

Results:

Nine trials met the criteria. Two studies showed a higher clinical cure rate in the quinolone group (93 per centvs71 per cent,p= 0.04, and 76 per centvs52 per cent,p= 0.009). Four studies showed no statistically significant difference in clinical outcome. A significant difference in microbiological clearance in favour of quinolones was shown in two studies (88 per centvs30 per cent,p< 0.001, and 88 per centvs30 per cent,p< 0.001).

Conclusion:

Topical quinolones do not carry the same risk of ototoxicity as aminoglycosides. Furthermore, they are equal or more effective in treating chronic suppurative otitis media and when used as prophylaxis post-myringotomy. Topical quinolones should be considered a first-line treatment for these patients.
The great mimicker: a rare case of head and neck inflammatory pseudotumour in the presence of human immunodeficiency virus
Authors: Ramotar H , Cheung L , Pitkin L
Published: November 2015

Background:

Inflammatory pseudotumours of the head and neck are rare. A connection has been made between inflammatory pseudotumours and human immunodeficiency virus positivity.

Case report:

This paper reports a case of an inflammatory pseudotumour presenting with a lesion in the left tonsil and left cervical lymph node in a 49-year-old human immunodeficiency virus positive patient. A histological diagnosis was obtained after biopsy and serial radiological imaging.

Conclusion:

Diagnostic uncertainties can lead to unnecessary surgery. It is important to recognise the clinical, radiological and histological indicators of an inflammatory pseudotumour to enable a timely diagnosis and arrange appropriate treatment. In patients with co-morbidities causing immunocompromise, the potential diagnosis of an inflammatory pseudotumour should be considered. This is especially the case in human immunodeficiency virus patients, as inflammatory pseudotumours have been associated with immune reconstitution inflammatory syndrome, which can manifest up to several years after the initiation of, or change in, antiretroviral therapies.
Marine harmful algal blooms, human health and wellbeing: challenges and opportunities in the 21st century
Authors: Berdalet Elisa , Fleming Lora E. , Gowen Richard , Davidson Keith , Hess Philipp , Backer Lorraine C. , Moore Stephanie K. , Hoagland Porter , Enevoldsen Henrik
Published: November 2015

Microalgal blooms are a natural part of the seasonal cycle of photosynthetic organisms in marine ecosystems. They are key components of the structure and dynamics of the oceans and thus sustain the benefits that humans obtain from these aquatic environments. However, some microalgal blooms can cause harm to humans and other organisms. These harmful algal blooms (HABs) have direct impacts on human health and negative influences on human wellbeing, mainly through their consequences to coastal ecosystem services (fisheries, tourism and recreation) and other marine organisms and environments. HABs are natural phenomena, but these events can be favoured by anthropogenic pressures in coastal areas. Global warming and associated changes in the oceans could affect HAB occurrences and toxicity as well, although forecasting the possible trends is still speculative and requires intensive multidisciplinary research. At the beginning of the 21st century, with expanding human populations, particularly in coastal and developing countries, mitigating HABs impacts on human health and wellbeing is becoming a more pressing public health need. The available tools to address this global challenge include maintaining intensive, multidisciplinary and collaborative scientific research, and strengthening the coordination with stakeholders, policymakers and the general public. Here we provide an overview of different aspects of the HABs phenomena, an important element of the intrinsic links between oceans and human health and wellbeing.
Die syntaktische Funktion von ὅτι in Joh 8.47
Authors: Förster Hans
Published: November 2015

A causal clause is often used to translate ὅτι in John 8.47. This, in combination with a problematic translation of the prepositional phrase διὰ τοῦτο, creates (in the translations) a logical argument that is contrary to the argument in Greek. The NRSV translates: ‘Whoever is from God hears the words of God. The reason you do not hear them is that you are not from God.’ The translation is somewhat different from the King James Version, which interprets the ὅτι-clause as causal: ‘He that is of God heareth God's words: ye therefore hear them not, because ye are not of God.’ Both translations and the implied logic must be rejected for philological reasons. The correct translation is: ‘He that is of God hears God's words. From this follows: you do not hear. Thus, you are not of God.’ The difference is obvious: the logical argument is turned on its head. The usual way to translate this argument implies a predestination: the Jews are simply ‘not of God’. The semantically correct translation makes obvious the connection between their decision (i.e. not to listen to Jesus) and the judgement spoken by Jesus.
Presenting the Pauline Voice: An Appreciation of the Letter to the Laodiceans
Authors: Longenecker Bruce W. , Ryan Scott C.
Published: November 2015

It is commonly thought that the apocryphal Letter to the Laodiceans was composed by an author who was little more than an editor, piecing together phrases from Pauline texts in a mediocre fashion. Not only does the text seem devoid of conceptual rigour and theological merit, but it is also thought to lack a coherent structure. This essay proposes that, to the contrary of most estimates, the Letter to the Laodiceans exhibits a discernible structural coherence from which a rhetorical strategy is evident.
Market Reforms and Water Wars
Authors: Simmons Erica S.
Published: November 2015

Responses to the imposition of market-oriented economic policies have varied. This article asks two questions: (1) How can we better understand when marketization will or will not prompt resistance? And (2) when people do mobilize, why are some movements broad-based while others draw on particular segments of society? The author argues that these questions can best be answered by focusing not only on the political contexts and resources available to potential social movements, but also on what is perceived to be at stake during marketization. These perceptions influence mobilization processes and the kinds of groups available for mobilization. When people understand markets as threatening to material wellbeing, as well as to widely shared community relationships, understandings, and commitments, heightened feelings of group belonging can contribute to broad-based mobilization. The author develops this argument through analysis of the broad-based, widespread movement that emerged to protest water privatization in Cochabamba, Bolivia, in 1999 and 2000. In the context of a history of agriculture, irrigation, drought, and conflict, water helped to produce and reproduce imagined communities of nation, region, and ethnic group, as well as quotidian communities revolving around the routine production and consumption of water. These meanings help to explain the dynamics of the resistance that emerged.
Music in the Life Skills classroom
Authors: van Vuuren Eurika Jansen , van Niekerk Caroline
Published: November 2015

Generalist educators in South Africa shy away from music in the subjects Life Skills (Dance, Drama, Music, Visual Art, Physical Education and Personal and Social Well-being) and Creative Arts (Dance, Drama, Music, Visual Art) and universities are not delivering generalist students for the subject demands. In-service educators, as well as subject advisors, often have had no music training. The twofold purpose of this study was to determine the extent of challenges experienced in the music component of Life Skills and Creative Arts in South Africa and how this can best be dealt with. In the current study, mixed methods research was conducted to ascertain the problems experienced with music tuition in Life Skills and Creative Arts classrooms. It was found that generalist educators have to teach music, whether they have the requisite skills or not. The subject has low status and is frequently used as a filler subject for teachers. Lack of music knowledge, scarce resources, limited support and ever-changing educators are some reasons for the absence of quality music tuition. Mentoring by competent subject advisors and senior educators and the re-alignment of school and university curricula will assist music in enjoying its rightful place in the school curriculum.
The Singing Teacher's Role in Educating Children's Abilities, Sensibilities and Sensitivities
Authors: Akuno Emily Achieng'
Published: November 2015

In the Republic of Kenya, song is widely used to enhance the whole curriculum in lower primary classes. Song is used especially to aid recall and therefore teachers adapt tunes that children already know, inserting relevant words from the subject at hand. Despite this widespread practice, this form of singing in schools is not recognised by the same teachers as music training in the classroom, and so little, if any, effort is put into the actual music production. Teachers do not attend to the sound of the music, as the intention is to capture facts about various things, including the soil, the weather, numbers etc. and present them in a way that the young learners will quickly remember. This paper interrogates the process that 6–8-year-old children underwent as they moved from using song to learn facts (singing to learn), to developing multiple musical abilities and capacities (learning to sing), through participation in the Music for Literacy Development (MLD)1 project in selected schools in the Nyanza region of Kenya.
The transformation of music education: A South African case study
Authors: de Villiers Alethea
Published: November 2015

In this paper I reflect on transformation in South African education policy, post-1994. The new curriculum for schools was underpinned by the democratic values of the constitution and was a time of renewal for music education. However, over time as the original curriculum documents were revised, the focus of promoting indigenous traditions was abandoned and replaced by an overtly Western approach to music education. It is against this background that I also reflect on the transformation that occurred as a result of a continuing professional development programme that arose from a need to improve curriculum implementation in the arts.
How children aged 2;6 tailor verbal expressions to interlocutor informational needs
Authors: ABBOT-SMITH KIRSTEN , NURMSOO ERIKA , CROLL REBECCA , FERGUSON HEATHER , FORRESTER MICHAEL
Published: November 2015

Although preschoolers are pervasively underinformative in their actual usage of verbal reference, a number of studies have shown that they nonetheless demonstrate sensitivity to listener informational needs, at least when environmental cues to this are obvious. We investigated two issues. The first concerned the types of visual cues to interlocutor informational needs which children aged 2;6 can process whilst producing complex referring expressions. The second was whether performance in experimental tasks related to naturalistic conversational proficiency. We found that 2;6-year-olds used fewer complex expressions when the objects were dissimilar compared to highly similar objects, indicating that they tailor their verbal expressions to the informational needs of another person, even when the cue to the informational need is relatively opaque. We also found a correlation between conversational skills as rated by the parents and the degree to which 2;6-year-olds could learn from feedback to produce complex referring expressions.
Lower bounds for the first Dirichlet eigenvalue of the Laplacian for domains in hyperbolic space
Authors: ARTAMOSHIN SERGEI
Published: November 2015

We consider domains in a simply connected space of constant negative curvature and develop a new technique that improves existing classical lower bound for Dirichlet eigenvalues obtained by H. P. McKean as well as the lower bounds recently obtained by A. Savo.
A Protocol for Recording Visual and Motor Behaviour for Scientific Support in the Teaching and Training of Sailing in a Simulator
Authors: Manzanares Aarón , Segado Francisco , Menayo Ruperto
Published: November 2015

This research aims to test the suitability of a protocol for automated measurement to describe visual and motor behaviour in the process of learning to sail. The objective is to provide coaches with the necessary scientific and technological support to analyse the variables of success in race starting. The study was performed with a highly ranked sailor in the Optimist class ranking. The instruments used to carry out the investigation were the sailing simulator VSail-Trainer®and the eye tracking system ASL®. Two simulated race starts were performed with a protocol of five minutes. The results show the automated protocol is suitable for measuring the ability of boat handling and visual performance in simulated conditions. Visual behaviour shows that the sailor visually fixates on locations that provide relevant information for the race start such as clock, other competitors, wind direction and the start buoys.
Are ready-to-eat salads ready to eat? An outbreak of Salmonella Coeln linked to imported, mixed, pre-washed and bagged salad, Norway, November 2013
Authors: VESTRHEIM D. F. , LANGE H. , NYGÅRD K. , BORGEN K. , WESTER A. L. , KVARME M. L. , VOLD L.
Published: November 2015

We investigated a nationwide outbreak of Salmonella Coeln in Norway, including 26 cases identified between 20 October 2013 and 4 January 2014. We performed a matched case-control study, environmental investigation and detailed traceback of food purchases to identify the source of the outbreak. In the case-control study, cases were found to be more likely than controls to have consumed a ready-to-eat salad mix (matched odds ratio 20, 95% confidence interval 2·7–∞). By traceback of purchases one brand of ready-to-eat salad was indicated, but all environmental samples were negative for Salmonella. This outbreak underlines that pre-washed and bagged salads carry a risk of infection despite thorough cleaning procedures by the importer. To further reduce the risk of infection by consumption of ready-to-eat salads product quality should be ensured by importers. Outbreaks linked to salads reinforce the importance of implementation of appropriate food safety management systems, including good practices in lettuce production.
On the structure of generalized Poisson–Boltzmann equations
Authors: GAVISH N. , PROMISLOW K.
Published: November 2015

In this work, we analyse a broad class of generalized Poisson–Boltzmann equations and reveal a common mathematical structure. In the limit of a wide electrode, we show that a broad class of generalized Poisson–Boltzmann equations admits a reduction that affords an explicit connection between the functional form of the corresponding free energy and the associated differential capacitance data. We exploit the relation to we show that differential capacitance curves generically undergo an inflection transition with increasing salt concentration, shifting from a local minimum near the point of zero charge for dilute solutions to a local maximum point near the point of zero charge for concentrated solutions. In addition, we develop a robust numerical method for solving generalized Poisson–Boltzmann equations which is easily applicable to the broad class of generalized Poisson–Boltzmann equations with very few code adjustments required for each model
Interleaving data and effects
Authors: ATKEY ROBERT , JOHANN PATRICIA
Published: November 2015

The study of programming with and reasoning about inductive datatypes such as lists and trees has benefited from the simple categorical principle of initial algebras. In initial algebra semantics, each inductive datatype is represented by an initial f-algebra for an appropriate functor f. The initial algebra principle then supports the straightforward derivation of definitional principles and proof principles for these datatypes. This technique has been expanded to a whole methodology of structured functional programming, often called origami programming.

In this article we show how to extend initial algebra semantics from pure inductive datatypes to inductive datatypes interleaved with computational effects. Inductive datatypes interleaved with effects arise naturally in many computational settings. For example, incrementally reading characters from a file generates a list of characters interleaved with input/output actions, and lazily constructed infinite values can be represented by pure data interleaved with the possibility of non-terminating computation. Straightforward application of initial algebra techniques to effectful datatypes leads either to unsound conclusions if we ignore the possibility of effects, or to unnecessarily complicated reasoning because the pure and effectful concerns must be considered simultaneously. We show how pure and effectful concerns can be separated using the abstraction of initial f-and-m-algebras, where the functor f describes the pure part of a datatype and the monad m describes the interleaved effects. Because initial f-and-m-algebras are the analogue for the effectful setting of initial f-algebras, they support the extension of the standard definitional and proof principles to the effectful setting.

Initial f-and-m-algebras are originally due to Filinski and Støvring, who studied them in the category Cpo. They were subsequently generalised to arbitrary categories by Atkey, Ghani, Jacobs, and Johann in a FoSSaCS 2012 paper. In this article we aim to introduce the general concept of initial f-and-m-algebras to a general functional programming audience.
The importance of forests along submontane stream valleys for bird conservation: The Carpathian example
Authors: KAJTOCH ŁUKASZ , WILK TOMASZ , BOBREK RAFAŁ , MATYSEK MARCIN
Published: November 2015

The biodiversity and naturalness of forests that cover stream valleys in submontane areas have not been investigated as intensively as riparian forests along large lowland rivers. In this study we compared data on total bird assemblages and on selected indicator species detected in forests along submontane stream valleys (‘Vall’) with those detected in forests covering submontane slopes and tops in the foothills (‘Hill’) of the Western Carpathians, considering also environmental characteristics of the studied locations. The aim of this study was to verify the hypothesis that forests along submontane stream valleys harbour significantly richer and more diverse bird communities and that they are an important habitat for rare and threatened species. We found that the species richness, abundance of birds and bird diversity were almost twice as high in ‘Vall’ than in ‘Hill’ locations and that indicator species mostly or exclusively inhabit ‘Vall’ locations. Moreover, species diversity was highly and positively correlated with higher tree species diversity and a higher amount of large trees and dead wood, but negatively correlated with logging intensity. The results of our study confirmed that forested river valleys in submontane areas play an important role as refugia both for rare and endangered bird species as well as for the whole bird assemblage. This study is the first to present an assessment of this type of habitat for birds in the Western Carpathians. Forests along submontane stream valleys, if protected or unmanaged, could be treated as reference areas for nature and biodiversity conservation.
Food avoidance in an Australian adult population sample: the case of dairy products
Authors: Yantcheva Bella , Golley Sinéad , Topping David , Mohr Philip
Published: November 2015

Objective

To assess the prevalence of and explanations for the avoidance of dairy foods, including symptoms attributed to their consumption, diagnoses and psychological predictors of avoidance. Also considered were comparisons with symptom-related avoidance of wheat in the same sample.

Design

Cross-sectional population survey.

Setting

The study was conducted in Australia using a national postal omnibus survey.

Subjects

Adults aged 18 years and over (n 1184; 52·9 % female) selected at random from the Australian Electoral Roll.

Results

Despite few claims of formally diagnosed allergy or intolerance, 11·8 % of the sample reported avoiding dairy products because of adverse physiological effects, which commonly included gastrointestinal symptoms. Unlike wheat (3·5 %) or wheat-and-dairy (3·6 %) avoidance, dairy avoidance (8·2 %) was predicted by age (negatively) and worry about illness (positively).

Conclusions

The findings are further evidence of a widespread tendency for consumers to exercise control over their health by eliminating dietary factors considered suspect without medical evidence or oversight. Unanswered questions include the decision processes underlying dairy avoidance, whether symptoms are attributed correctly, the agents and physiological mechanism(s) involved, the relative contributions of symptom severity and vigilance to the association with illness worry, and the nutritional adequacy of dairy avoiders’ diets. Irrespective of the accuracy of self-diagnoses, if the elimination of suspect foods is an end in itself the paradoxical possibility for nutritional imbalances may have significant public health implications.
RELATIVE ELEMENTARY ABELIAN GROUPS AND A CLASS OF EDGE-TRANSITIVE CAYLEY GRAPHS
Authors: LI CAI HENG , WANG LEI
Published: November 2015

Motivated by a problem of characterising a family of Cayley graphs, we study a class of finite groups $G$ which behave similarly to elementary abelian $p$-groups with $p$ prime, that is, there exists a subgroup $N$ such that all elements of $G\setminus N$ are conjugate or inverse-conjugate under $\mathsf{Aut}(G)$. It is shown that such groups correspond to complete multipartite graphs which are normal edge-transitive Cayley graphs.
Pareto optimization of radar receiver low-noise amplifier source impedance for low noise and high gain
Authors: Baylis Charles , Marks Robert J. , Cohen Lawrence
Published: November 2015

In radar receivers, the low noise amplifier(LNA)must provide very low noise figure and high gain to successfully receive very low signals reflected off of illuminated targets. Obtaining low noise figure and high gain, unfortunately, is a well-known trade-off that has been carefully negotiated by design engineers for years. This paper presents a fundamental solution method for the source reflection coefficient providing the maximum available gain under a given noise figure constraint, and also for the lowest possible noise figure under a gain constraint. The design approach is based solely on the small-signal S-parameters and noise parameters of the device; no additional measurements or information are required. This method is demonstrated through examples. The results are expected to find application in design of LNAs and in real-time reconfigurable amplifiers for microwave communication and radar receivers.
Wideband four-element two-segment triangular dielectric resonator antenna with monopole-like radiation
Authors: Gangwar Ravi Kumar , Ranjan Pinku , Aigal Abhishek
Published: November 2015

In this paper, a wideband two-segmented four-element triangular dielectric resonator antenna (TDRA) with coaxial probe feed has been proposed. The proposed antenna has been analyzed, optimized, and studied through Ansoft HFSS simulation software. The prototype of the proposed antenna has been fabricated and its input characteristics are measured with the help of R&S Vector Network Analyzer. Good agreement has been obtained between simulated and measured results. The proposed design has been compared with two segments TDRA and found wider bandwidth with lower resonant frequency. The proposed antenna provides monopole-like radiation pattern over the entire bandwidth with nearly 33% bandwidth (return loss ≥10 dB) at a resonant frequency 6.9 GHz and 4.93 dBi peak gain. The proposed antenna is suitable for application of C-band microwave frequencies.
The Hierarchical Model of Exercise Dependence
Authors: Kotbagi Gayatri , Kern Laurence , Romo Lucia , Pathare Ramesh
Published: November 2015

Abstract. Physical exercise when done excessively may have negative consequences on physical and psychological wellbeing. There exist many scales to measure this phenomenon. The purpose of this article is to create a scale measuring the problematic practice of physical exercise (PPPE Scale) by combining two assessment tools already existing in the field of exercise dependency but anchored in different approaches (EDS-R and EDQ). This research consists of three studies carried out on three independent sample populations. The first study (N = 341) tested the construct validity (exploratory factor analysis); the second study (N = 195) tested the structural validity (confirmatory factor analysis) and the third study (N = 104) tested the convergent validity (correlations) of the preliminary version of the PPPE scale. Exploratory factor analysis identified six distinct dimensions associated with exercise dependency. Furthermore, confirmatory factor analysis validated a second order model consisting of 25 items with six dimensions and four sub-dimensions. The convergent validity of this scale with other constructs (GLTEQ, EAT26, and The Big Five Inventory [BFI]) is satisfactory. The preliminary version of the PPPE must be administered to a large population to refine its psychometric properties and develop scoring norms.
Grit
Authors: Abuhassàn Abedrahman , Bates Timothy C.
Published: November 2015

Abstract. Maximizing the translation of ability into accomplishment is of considerable interest. A two-factor construct of “grit” as perseverance and consistency of interest has been argued to predict accomplishment over and above personality and IQ ( Duckworth, Peterson, Matthews, & Kelly, 2007 ). Here we test this in linked analyses addressing the structure of Grit and its fit within broader personality and intelligence constructs. An initial Structural Equation Model (SEM) in 494 subjects (age 18–69 years) confirmed a two-factor structure of the Grit scales. Tests adding facet-level assessments of conscientiousness (C) and neuroticism (N) indicated that while grit consistency fit well under C, grit perseverance and related measures of control defined an “effortful persistence” construct which could not be reduced to effects of C and/or N. While conscientiousness and IQ adequately accounted for school grades, higher perseverance was associated with higher life-course accomplishment. The work supports three factors of central relevance to achievement: IQ, conscientiousness, and effortful persistence, each with distinct mechanisms.
Beyond An Informal Everyday Concept of Self-Esteem
Authors: Hank Petra
Published: November 2015

Abstract. The present study investigated a state-trait model of self-esteem. Analyses focused on determining if the trait of the observables measuring state self-esteem is equivalent to the trait of the observables measuring trait self-esteem. N = 439 college students completed the Multidimensional Scale of Self-Esteem (MSES) on two measurement occasions spaced 10 weeks apart. Structural equation models were used to test latent state-trait measurement models and the relation between the state and trait components of self-esteem. The results suggest that (1) except for physical self-esteem, the multi-state-single-trait models are suitable for all self-esteem dimensions investigated. This holds for the state test halves as well as for the trait test halves. (2) Concerning the association between the components of trait and state self-esteem, results were supportive of a model, including two latent trait variables, assumed to explain the latent state variables for the respective state form and trait form for the dimensions of general self-esteem. These latent trait factors correlate substantively with .94 ≤ r ≤ .99.
Polyphenols act synergistically with doxorubicin and etoposide in leukaemia cell lines
Authors: Mahbub AA , Le Maitre CL , Haywood-Small SL , Cross NA , Jordan-Mahy N
Published: November 2015

The study aimed to assess the effects of polyphenols when used in combination with doxorubicin and etoposide, and to determine whether polyphenols sensitised leukaemia cells, causing inhibition of cell proliferation, cell cycle arrest and induction of apoptosis. This study is based on findings in solid cancer tumours, which have shown that polyphenols can sensitize cells to chemotherapy, and induce apoptosis and/or cell-cycle arrest. This could enable a reduction of chemotherapy dose and off-target effects, whilst maintaining treatment efficacy. Quercetin, apigenin, emodin, rhein and cis-stilbene were investigated alone and in combination with etoposide and doxorubicin in two lymphoid and two myeloid leukaemia cells lines. Measurements were made of ATP levels (using CellTiter-Glo assay) as an indication of total cell number, cell cycle progression (using propidium iodide staining and flow cytometry) and apoptosis (NucView caspase 3 assay and Hoechst 33342/propidium iodide staining). Effects of combination treatments on caspases 3, 8 and 9 activity were determined using Glo luminescent assays, glutathione levels were measured using the GSH-Glo Glutathione Assay and DNA damage determined by anti-γH2AX staining. Doxorubicin and etoposide in combination with polyphenols synergistically reduced ATP levels, induced apoptosis and increased S and/or G2/M phase cell cycle arrest in lymphoid leukaemia cell lines. However, in the myeloid cell lines the effects of the combination treatments varied; doxorubicin had a synergistic or additive effect when combined with quercetin, apigenin, emodin, and cis-stilbene, but had an antagonistic effect when combined with rhein. Combination treatment caused a synergistic downregulation of glutathione levels and increased DNA damage, driving apoptosis via caspase 8 and 9 activation. However, in myeloid cells where antagonistic effects were observed, this was associated with increased glutathione levels and a reduction in DNA damage and apoptosis. This study has demonstrated that doxorubicin and etoposide activity were enhanced by polyphenols in lymphoid leukaemia cells, however, differential responses were seen in myeloid cells with antagonistic responses seen in some combination therapies.
Calcium oxalate toxicity in renal epithelial cells: the mediation of crystal size on cell death mode
Authors: Sun X-Y , Gan Q-Z , Ouyang J-M
Published: November 2015

The cytotoxicity of calcium oxalate (CaOx) in renal epithelial cells has been studied extensively, but the cell death mode induced by CaOx with different physical properties, such as crystal size and crystal phase, has not been studied in detail. In this study, we comparatively investigated the differences of cell death mode induced by nano-sized (50 nm) and micron-sized (10 μm) calcium oxalate monohydrate (COM) and calcium oxalate dihydrate (COD) to explore the cell death mechanism. The effect of the exposure of nano-/micron-sized COM and COD crystals toward the African green monkey renal epithelial (Vero) cells were investigated by detecting cell cytoskeleton changes, lysosomal integrity, mitochondrial membrane potential (Δψm), apoptosis and/or necrosis, osteopontin (OPN) expression, and malondialdehyde (MDA) release. Nano-/micron-sized COM and COD crystals could cause apoptosis and necrosis simultaneously. Nano-sized crystals primarily caused apoptotic cell death, leading to cell shrinkage, phosphatidylserine ectropion, and nuclear shrinkage, whereas micron-sized crystals primarily caused necrotic cell death, leading to cell swelling and cell membrane and lysosome rupture. Nano-sized COM and COD crystals induced much greater cell death (sum of apoptosis and necrosis) than micron-sized crystals, and COM crystals showed higher cytotoxicity than the same-sized COD crystals. Both apoptosis and necrosis could lead to mitochondria depolarization and elevate the expression of OPN and the generation of lipid peroxidation product MDA. The amount of expressed OPN and generated MDA was positively related to cell injury degree. The physicochemical properties of crystals could affect the cell death mode. The results of this study may provide a basis for future studies on cell death mechanisms.
c-MYC responds to glucose deprivation in a cell-type-dependent manner
Authors: Wu S , Yin X , Fang X , Zheng J , Li L , Liu X , Chu L
Published: November 2015

Metabolic reprogramming supports cancer cells’ demands for rapid proliferation and growth. Previous work shows that oncogenes, such as MYC, hypoxia-inducible factor 1 (HIF1), have a central role in driving metabolic reprogramming. A lot of metabolic enzymes, which are deregulated in most cancer cells, are the targets of these oncogenes. However, whether metabolic change affects these oncogenes is still unclear. Here we show that glucose deprivation (GD) affects c-MYC protein levels in a cell-type-dependent manner regardless of P53 mutation status. GD dephosphorylates and then decreases c-MYC protein stability through PI3K signaling pathway in HeLa cells, but not in MDA-MB-231 cells. Role of c-MYC in sensitivity of GD also varies with cell types. c-MYC-mediated glutamine metabolism partially improves the sensitivity of GD in MDA-MB-231 cells. Our results reveal that the heterogeneity of cancer cells in response to metabolic stress should be considered in metabolic therapy for cancer.
Correction: Corrigendum: IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel
Authors: Wee Zhen Ning , Yatim Siti Maryam J. M. , Kohlabauer Vera K. , Feng Min , Goh Jian Yuan , Bao Yi , Lee Puay Leng , Zhang Songjing , Wang Pan Pan , Lim Elgene , Tam Wai Leong , Cai Yu , Ditzel Henrik J. , Hoon Dave S. B. , Tan Ern Yu , Yu Qiang
Published: November 2015

Nature Communications 6: Article number: 8746 (2015); Published: 27 October 2015; Updated: 20 November 2015 The original version of this Article contained an error in the spelling of the author Yi Bao, which was incorrectly given as Bao Yi. This has now been corrected in both the PDF and HTML versions of the Article.
Photoreactive helical nanoaggregates exhibiting morphology transition on thermal reconstruction
Authors: Yamauchi Mitsuaki , Ohba Tomonori , Karatsu Takashi , Yagai Shiki
Published: November 2015

The supramolecular design of photochromic molecules has produced various smart molecular assemblies that can switch their structures and/or functions in response to light stimuli. However, most of these assemblies require large structural changes of the photochromic molecules for an efficient conversion of assembled states, which often suppresses the photoreactivity within the self-assemblies. Here we report molecular assemblies, based on a photo-cross-linkable chromophoric dyad, in which a small amount of ultraviolet-generated photochemical product can guide the entire system into different assembly processes. In apolar solution, the intact dyad self-assembles into right-handed superhelical fibrils. On ultraviolet-irradiation of these fibrils, an effective photoreaction affords a sole photo-cross-linked product. When right-handed helical fibrils, containing a minor amount of the photoproduct, are thermally reconstructed, the intact molecule and the photoproduct undergo a co-assembly process that furnishes superhelical fibrils with different molecular packing structures. This molecular design principle should afford new paradigms for smart molecular assemblies.
Superfluidity in topologically nontrivial flat bands
Authors: Peotta Sebastiano , Törmä Päivi
Published: November 2015

Topological invariants built from the periodic Bloch functions characterize new phases of matter, such as topological insulators and topological superconductors. The most important topological invariant is the Chern number that explains the quantized conductance of the quantum Hall effect. Here we provide a general result for the superfluid weightDsof a multiband superconductor that is applicable to topologically nontrivial bands with nonzero Chern numberC. We find that the integral over the Brillouin-zone of the quantum metric, an invariant calculated from the Bloch functions, gives the superfluid weight in a flat band, with the boundDs⩾|C|. Thus, even a flat band can carry finite superfluid current, provided the Chern number is nonzero. As an example, we provideDsfor the time-reversal invariant attractive Harper–Hubbard model that can be experimentally tested in ultracold gases. In general, our results establish that a topologically nontrivial flat band is a promising concept for increasing the critical temperature of the superconducting transition.
Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans
Authors: Whittle Andrew J. , Jiang Meizi , Peirce Vivian , Relat Joana , Virtue Sam , Ebinuma Hiroyuki , Fukamachi Isamu , Yamaguchi Takashi , Takahashi Mao , Murano Takeyoshi , Tatsuno Ichiro , Takeuchi Masahiro , Nakaseko Chiaki , Jin Wenlong , Jin Zhehu , Campbell Mark , Schneider Wolfgang J. , Vidal-Puig Antonio , Bujo Hideaki
Published: November 2015

Thermogenesis in brown adipose tissue (BAT) is an important component of energy expenditure in mammals. Recent studies have confirmed its presence and metabolic role in humans. Defining the physiological regulation of BAT is therefore of great importance for developing strategies to treat metabolic diseases. Here we show that the soluble form of the low-density lipoprotein receptor relative, LR11/SorLA (sLR11), suppresses thermogenesis in adipose tissue in a cell-autonomous manner. Mice lacking LR11 are protected from diet-induced obesity associated with an increased browning of white adipose tissue and hypermetabolism. Treatment of adipocytes with sLR11 inhibits thermogenesis via the bone morphogenetic protein/TGFβ signalling pathway and reduces Smad phosphorylation. In addition, sLR11 levels in humans are shown to positively correlate with body mass index and adiposity. Given the need for tight regulation of a tissue with a high capacity for energy wastage, we propose that LR11 plays an energy conserving role that is exaggerated in states of obesity.