bluuebunny/crossref_metadata_2025 huggingface dataset:
INNOVATIVE SCIENTIFIC CONCEPT OF TOPICAL VIRUS GLYCOPROTEIN INHIBITORS INCORPORATED IN HYPEROSMOTIC GLYCEROL REVOLUTIONIZES FUTURE PROSPECTS IN THE TREATMENT OF VIRAL AND BACTERIAL THROAT INFECTIONS
Authors: Rousse M. , Cucuat N. , Janicot C. , Shrivastava R.
Published: January 2025

Pharyngitis is primarily a viral infection of the respiratory tract, followed by secondary bacterial invasion due to weakening of local defenses. Influenza A and rhinoviruses are principally involved, the influenza virus having much higher pathogenicity, however, than rhinoviruses which usually cause the common cough and cold without severe damage to the respiratory mucosa. Following initial infection, the virus enters the cells only for multiplication and almost all virulent virus particles subsequently produced are shed onto the throat surface. From the throat surface, the virions infect new healthy cells, damaging the throat mucosa, and creating a favorable ground for secondary bacterial colonization which is the cause of almost all symptoms of throat infection (sore throat, strep throat). The virus’ complex structure, its constant mutation, the variety of its surface glycoproteins, as well as the role of topical proteases helping virus entry and virus – bacteria symbiosis must all be taken into account in designing an effective treatment, acting on multiple parameters. As most viruses and all bacteria are present on the throat’s outer lining, treatment should be designed to act topically on the surface of the pharynx, which also minimizes side effects. Until 2012, no topical antiviral drugs were available and almost all treatment strategies were directed to relieve only the symptomatic manifestations of throat infections. Anti-influenza vaccination is still considered the best preventive measure, while the use of intracellular virus inhibitors is strictly limited to severe cases as they were not found to be very effective once throat infection is established. The recent development of non-specific topical virus glycoprotein inhibitors, incorporated in a filmogen glycerol solution for an increased duration of action, represents a breakthrough yet relatively simple scientific approach for the treatment of viral throat infections accompanied by secondary bacterial infection. In this review, we analyze the whole process of viral throat infection, virus – bacteria interactions on the throat surface, currently available treatments and their drawbacks, and this innovative therapeutic approach consisting in virus glycoprotein inhibitors in an osmotic solution, destined to totally change the future treatment of throat infections.
ANTITUSSIVE MEDICINAL HERBS - AN UPDATE REVIEW
Authors: Saraswathy G. R. , Sathiya R. , Anbu J. , Maheswari E.
Published: January 2025

The cough is a protective reflex mechanism that removes foreign material and secretions from the bronchi and bronchioles of the airways; it is inappropriately stimulated in various situations like inflammation of the respiratory tract or neoplasia. In these cases, cough has a pathological character and it is necessary sometimes to use cough-suppressant drugs. The most frequently used antitussive drugs in clinical conditions produce adverse effects like depression of the respiratory centre, decreased secretion in the bronchioles and inhibition of ciliary activity, increased sputum viscosity, decreased expectoration, hypotension and constipation acts as limitation to the therapy. Use of herbal drugs is increasing all over the world for various ailments including antitussive activity as they are safe and devoid of adverse effects. Medicinal plants are an important source for the discovery of novel bioactive compounds, which have served and continue to serve as lead molecules for the development of new drugs. Thus this review may provide an insight into herbs possessing antitussive activity.
IN-VITRO EVALUATION AND MOLECULAR DOCKING CALCULATION OF TRICYCLIC PHTHALIMIDE QUINOXALINE ANALOGUES AS NOVEL INHIBITORS OF HIV-1 INTEGRASE USING GLIDE AND GOLD
Authors: Balasubramanian S. , Sasikumar P. , Velmurugan D.
Published: January 2025

As quinoxaline analogues have been computationally shown to be competent with other commercial antiviral drugs in terms of size and efficacy, their lack of utility is exemplified in the case of HIV integrase. The ability of molecular docking methods to locate selective inhibitors reinforces our view of structure-based drug discovery as a valuable strategy, not only for identifying lead compounds, but also for addressing receptor specificity. This study focuses on series of ligands that are screened for a successful candidate drug using rational drug design. In the present work, we proposed and evaluated the interaction of quinoxaline analogues along with HIV integrase (1QS4) as target by using the docking program GOLD and GLIDE. To study the molecular basis of interaction and binding affinity of quinoxaline analogues, these compounds were docked into active site of receptor using GLIDE. The best 10 compounds were screened out using high throughput virtual screening. These 10 compounds were further subjected to Induced Fit Docking. Based on overall studies, we can conclude that quinoxaline compounds were found to be more potent inhibitors based on glide score, glide energy and interaction with residues in the active site of the HIV integrase (1QS4). In future, these ten compounds (CHEMBL35109, CHEMBL369834, CHEMBL177311, CHEMBL177547, CHEMBL177515, CHEMBL177405, CHEMBL177705, CHEMBL174851, CHEMBL367104, CHEMBL369841 and CHEMBL424782) can be considered as effective candidates for the second generation drug discovery.
PROSPECTS AND CONSEQUENCES OF HORMONE REPLACEMENT THERAPY IN CANCERS A REVIEW
Authors: Fatima Sara , Noor Sobia , Maazuddin Mohammed , Fatima Ayesha
Published: January 2025

Hormone replacement therapy (estrogens with or without progestogens) is widely used medication therapy worldwide for alleviating post menopausal symptoms. The association of Hormone replacement therapy (HRT) and risk of cancers leads to many studies. A lot of controversial results regarding the risk of cancers arises which leads to many questions that are still unanswered and can be cleared by further extensive research. There is considerable uncertainty among general practitioners to balance the beneficial and harmful effects of long term HRT particularly regarding the risk of cancers (breast, ovarian, endometrial, colorectal, lung cancers, lymphoma’s and leukaemia’s). The goal of HRT is not only to normalize the follicle stimulating hormone value, but rather to use the minimum effective dosage to suppress vasomotor reactions, treat urogenital atrophy, prevent trabecular and cortical bone loss, and reduce cardiac risk. Use of HRT should be individualized for risks and benefits of each patient that is being taken into consideration.
STUDIES ON ANTIMICROBIAL AND ANTIOXIDANT EFFICACY OF THEVETIA NERIIFOLIA, JUSS LEAF EXTRACTS AGAINST HUMAN SKIN PATHOGENS
Authors: A Nesy E , Mathew Lizzy
Published: January 2025

To evaluate the significance of Thevetia neriifolia in folk medicine for curing skin infections, an efficacy study was conducted using bacterial (Staphylococcus aureus, Streptococcus pyogenes, Nocardia asteroids, Proteus mirabilis and Pseudomonas aeruginosa) and fungal pathogens (Candida albicans and Trichophyton rubrum) that cause various dermatological disorders. For antimicrobial properties, different fractions of hot extracts of shade dried leaves were assessed by Agar well diffusion method using concentrations ranging from10 mg/50µl/well and compared with reference antibiotics Gentamicin and Fluconazole (25-50µg/well). Of these, petroleum ether fraction was almost ineffective; chloroform fraction showed better efficiency at very low dozes (0.05-0.0125 mg/well) against C. albicans (19.00±1.00) and N. asteroids (14.5±0.71), ethyl acetate fraction was sensitive at higher doses against both fungal cultures T. rubrum (17.67±0.58), C. albicans (15.33±0.58) followed by bacterial strain N. asteroids (15.67±1.52), where as methanol division inhibited colony growth moderately against all the tested organisms (10-13mm). Better DPPH free radical scavenging activity was shown by EA and MT fractions of hot extract with IC50 values 0.72 and 0.81mg/ml respectively. Similarly, cold methanol extract also acted as powerful free radical scavengers of DPPH, super oxide and nitric oxide with low IC50 Values (DPPH-0.46 mg/ml, SOD-0.91 mg/ml, NO-0.88 mg/ml). In conclusion, higher antimicrobial and antioxidant compounds in the leaf add more value to the therapeutic field in drug development for curing many cutaneous bacterial and fungal infections.
ANALYTICAL METHOD VALIDATION OF AN HERBAL FORMULATION BY HEADSPACE GAS CHROMATOGRAPHY USING QBD
Authors: Mazumder Joydeep , Pathak Devender , Kumria Rachna
Published: January 2025

Essential oils are rich sources of biologically active compounds possessing diverse medicinal properties. These form integral part of a number of herbal formulations. The most challenging part of commercialization of herbal formulation is to ensure consistency in quality from batch to batch. The aim of present study was to develop a validated gas chromatographic method based on quality by design (QbD) for routine quality control purpose. A blend of essential oils possessing synergistic carminative properties was formulated in oily base. Ajowan oil, cardamom oil, caraway oil, coriander and fennel oil were selected for development of formulation. A gas chromatography method was developed for routine quality control purpose of the developed formulation by quality by design techniques (QbD). Each oil was characterized making use of a marker compound which was linalool for coriander oil, cineol for cardamom oil, anethol for fennel oil, carvone for caraway oil, thymol for ajowan oil and menthol for peppermint oil. Marker compound was characterized using mass spectroscopy. Chromatography method was established by quality by design approach and validated based on ICH guidelines.
ANTI-FLATULENT STUDIES OF TRADITIONAL MEDICINAL PLANT VITEX NEGUNDO LINN. IN RATS
Authors: Khokra Sukhbir Lal , Kaushik Pawan , Kaushik Dhiender , Jain Sandeep
Published: January 2025

Vitex negundo is a shrub from Verbenaceae family and is traditionally used in treatment of various disease and disorders. Oil prepared with the juice of leaves of Vitex-negundo is reported to have very useful medicinal properties like wonderful cures of sloughing wounds and ulcers. In Ayurveda; roots of Vitex negundo is reported to have anti-flatulent properties. Philippines peoples used to make tea from fruits of this plant, which was considered very useful in relieving stomach gas which, we refer to flatulence. Here we studied the anti flatulent activity of different essential oils and extracts of Vitex negundo Linn. The standard drug used was simethicone (10 mg/10 g of flatulent diet, p.o.), which inhibited gas production up to 90 % as compared to control. Addition of test drugs (essential oils/ethanolic extracts) to the chickpea diet (5 %) decreased the amount of gas production significantly up to 69% by root and leaves extracts while dry fruit oil inhibited gas formation to 81%. The anti-flatulent activity in this plant may due to combined effect of flavonoids and triterpenoids constituents. As the safety evaluation study indicates that Vitex negundo is well tolerated at very high doses without any toxic effects. Thus, Vitex negundo has a high potential for the development of modern medicine for the treatment of various diseases.
IN-VITRO ANTHELMINTIC ACTIVITY OF OLEANDRA MUSIFOLIA (BL.) PRESL. AGAINST HAEMONCHUS CONTORTUS
Authors: Rajesh Kalpana Devi , Rajesh Nakulan Valsala , Vasantha Subramani , Jeeva Solomon
Published: January 2025

Ethanolic, aqueous and Petroleum ether extracts from the whole fern, Oleandra musifolia (Bl.) Presl. (Family-Oleandraceae) was investigated for anthelmintic activity against Haemonchus contortus, with varied drug concentration (25, 50, and 100) mg/ml and the time taken for paralysis and death of the worm was determined. The in-vitro anthelmintic activity was compared with standard reference drug Albendazole and control distilled water. The result showed ethanolic extract performed well to express the anthelmintic efficacy than aqueous and petroleum ether extracts and the standard Albendazole. However efficacy is better and directly proportional to the increase in varied drug concentration. The efficacy is determined as lesser time taken to cause paralysis and death of Haemonchus contortus as compared to standard reference drug.
FORMULATION, CHARACTERIZATION AND IN VITRO EVALUATION OF ENTACAPONE SOLID DISPERSIONS WITH LIPID CARRIERS BY USING SPRAY DRYING METHOD
Authors: M Ganesh. , K Ramesh. , Y Madhusudan Rao. , B Chandra Shekar.
Published: January 2025

In present study, immediate release solid dispersion formulation of Entacapone with various lipids was developed using spray drying method. Entacapone is indicated for the treatment of Parkinson’s disease (PD) as an adjunct to levodopa/carbidopa therapy. Based on the process feasibility and solubility of resulting spray dried powder, formulation ENSD10 was selected for characterization and analyzed for in vitro dissolution profiles in three different pH media. The particle size of Entacapone in spray dried formulation ENSD10 was drastically reduced down to d90 of 25.86µ against d90 of as such drug substance, i.e., 124.74µ. Analysis by differential scanning calorimetry showed that the percentage of crystallinity has been significantly reduced in formulation ENSD10.The optimized solid dispersion formulation (ENSD10) by spray drying method comprising drug to lipid to lipid carrier ratio of 0.5:1:3 (Entacapone: Gelucire 50/13: Compritol) enhanced solubility nearly 6.31 fold and 3.75 fold as compared to pure drug and spray drug alone, respectively. The rate of drug release from spray dried powder was significantly improved and found to be on higher side as compared to the drug release from as such drug and spray dried drug alone. The obtained results suggested that developed Entacapone along with lipid carrier mixture by spray drying method has promising potential for oral delivery and might be an efficacious approach for enhancing the therapeutic potential of active substance.
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR ESTIMATION OF EMBELIN IN EMBELIA TSJERIAM COTTAM
Authors: Kulkarni S. V. , Damle M. C.
Published: January 2025

Embelin, a naturally occurring benzoquinone, is obtained from fruits of Embelia tsjeriam cottam, which plays a vital role in the Ayurvedic system of medicine. An approach for the stress degradation was successfully applied for the development of stability indicating HPTLC method for the determination of Embelin. It was spotted on the plates precoated with silica gel 60 F254 and developed using toluene: ethyl acetate: formic acid, (6:3.5:0.5 v/v/v) as mobile phase. Densitometry analysis was carried out at 291 nm. The method showed high sensitivity with good linearity over the concentration range of 200-1000ng/spot with correlation coefficient value 0.997. The accuracy of the method was established based on the recovery studies. The LOD and LOQ were 6.09ng/band and 18.48ng/band respectively. The system showed a peak for Embelin at Rf of 0.68 ± 0.02.The aim of our study was to observe the effect of various stress conditions on this potential drug candidate. Stress testing of Embelin was carried out according to the International Conference of Harmonization (ICH) guideline Q1A (R2). Embelin was subjected to stress conditions of acid, alkaline hydrolysis, oxidation, photolysis and thermal degradation. A significant degradation was found to occur by acid and oxidation hydrolysis and to a lesser extent under thermal stress and alkaline hydrolysis; and much lesser with photolytic stress. Stress degradation studies on embelin provide an insight into its stability.
MEDICATION KNOWLEDGE LEVEL OF HYPERTENSIVE PATIENTS FROM SOUTH INDIAN HOSPITALS
Authors: Karthikeyan G. , Ranganayakulu D.
Published: January 2025

To estimate the patient’s antihypertensive medication knowledge from south Indian population. Five hundred (500) patients were participated in this study. Out of 500, 46 patients were pre hypertensive so 456 patients were interviewed using a questionnaire which captured data on patient’s medication knowledge at south Indian private hospitals in Tamilnadu, India. The present study consists 4 visits that include, screening visit, follow up visit-1 to follow up visit-3. The study measure the knowledge of drug level between usual care and pharmaceutical care. Usual care patients were not educated whereas pharmaceutical care patients were educated by principal researcher. Out of 500 patients, males (49.29 ± 6.5) and females (50.63 ± 6.5) participated in the study. Knowledge of medication and compliance are important in drug treatment regimens. In usual care, Out of 500 patients 65% of patients reported that they were aware that they were taking drugs for high blood pressure where as 35% were not. 32% of patients were able to tell the name of the drugs whereas 68% were not. 64% of the people were thinking it’s no cure for hypertension and only 36% of the people feel that it’s curable. 64% of the people said lifelong and only 36% of subjects said they are taking only for short term treatment of hypertension. 66% of the people have no clue and knowledge about the side effects of antihypertensive medicines where as 34% were aware, 33% were shared if they take any other drugs along with antihypertensive drugs where as 67% were not, 70% of the patients did not inform to the pharmacist about their high blood pressure (HBP) tablet intake while purchasing other medicines whereas 30% informed. However medication knowledge was improved after the pharmaceutical care.
DEVELOPMENT AND VALIDATION OF HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY FOR ESTIMATION OF MEFENAMIC ACID, PARACETAMOL AND DICYCLOMINE HCL IN TABLET DOSAGE FORM
Authors: Patel Twinkle K. , Meshram Dhananjay B.
Published: January 2025

High performance thin layer chromatographic method was described for the analysis of mefenamic acid, paracetamol and dicyclomine HCl in tablet dosage form. The method employed HPTLC aluminium plates precoated with Silica gel 60F254 as the stationary phase and mixture of Toluene: Acetone: Formic acid (10:9.8:0.2) as mobile Phase. The densitometric evaluation of separated bands was carried out at 254 nm for mefenamic acid and paracetamol. In method development, Dicyclomine HCl was not detected in UV absorbance at 254 nm, so that same plate was poured in dragandroff reagent and measured at 510 nm wavelength. The linear response was observed in range of 100-700 ng/spot with correlation coefficient of, 0.998, 0.997 and 0.978. Precision was found to be within limits. The percentage recovery was found to be the limits of acceptance criteria between the range of 99.03% to 101.24%.
Determination of Factors Associated with Glycemic Control in Women with Type 2 Diabetes: Nutrition and Physical Activity Level
Authors: Okur Ümmühan , Özaydın Tuba
Published: January 2025

Aim: Effective diabetes management is achieved with adequate glycemic control. Nutrition and physical activity have an important
role in glycemic control. This study was conducted to determine the relationship between glycemic control and nutrition attitude,
Mediterranean diet adherence and physical activity levels of women with Type 2 diabetes aged 20-64 years who applied to a state hospital
in Konya province.
Material and Methods: This correlational study was conducted with 246 women aged 20-64 years with Type 2 diabetes who applied
to the Internal Medicine and Endocrinology outpatient clinics of a hospital in Konya. Individuals were selected by random sampling
method. Data were collected using a questionnaire form, Attitudes Toward Healthy Eating Scale, Mediterranean Diet Adherence
Scale and International Physical Activity Questionnaire Short Form (IPAQ-SF). Descriptive statistics, Chi-Square, Fisher's exact test,
Kruskal Wallis test, Spearman correlation analysis and logistic regression analysis were used to analyze the data collected by face-to-face
interviews.
Results: In the study, glycated hemoglobin A1c (HbA1c) and fasting blood glucose (FBG) were used to assess glycemic control. 55.3%
and 56.9% of the individuals had poor glycemic control in terms of HbA1c and FBG, respectively. According to logistic regression
analysis, for HbA1c; having diabetes for more than 10 years (OR=0.291, 95% Cl=0.095-0.894), high triglycerides (OR=0.440, 95%
Cl=0.190-1.017) and low high density lipoprotein (HDL) (OR=0.293, 95% Cl=0.114-0.753); For FBG, increased frequency of skipping medication and insulin use (OR=2.431, 95% Cl=1.090-5.424) and low HDL level (OR=0.269, 95% Cl=0.110-0.653) were significant
risk factors. Among the individuals, 73.2% had a moderate attitude towards healthy eating, 46.3% had a moderate adherence to the
Mediterranean diet and 60.6% were physically inactive. In addition, there was a very weak negative significant correlation (p
La seguridad humana, una perspectiva del poder terrestre en Colombia
Authors: Londoño Londoño Cesar Augusto
Published: January 2025

La seguridad humana es una expresión que tiene su origen durante la Segunda Guerra Mundial, pero tomó mayor relevancia en 1994 cuando se presentó en uno de los informes que realiza anualmente el Programa de las Naciones Unidas para el Desarrollo (PNUD), como una nueva noción de seguridad, centrada en las personas y las comunidades, más que en los Estados. Este escenario llevó a los organismos de seguridad y defensa a tomar medidas para disminuir las vulnerabilidades y reducir los riesgos a los que estaba expuesto el ser humano, lo cual se tradujo en cambios doctrinales y estructurales que permitieran emplear el concepto. El presente artículo analiza la aplicación de la seguridad humana en el Ejército Nacional de Colombia en el período 2010-2022, con el fin de identificar la integración de este modelo en la doctrina del dominio terrestre y su aporte a la seguridad y defensa.
First International Relay Map
Authors: Runners Odeimin
Published: January 2025

The Odeimin Runners art collective strives to foster and nourish relations between communities. The First International Relay Map visualizes Indigenous and Caribbean embodied mapping methodologies as an interactive storymap representing the multiple interconnections of three different geographies: St. Elizabeth, Jamaica; Saugeen First Nation; Wasauksing First Nation.
Placemaking as Public Space Planning Tool in New Providence, Bahamas
Authors: Pratt Nastassia
Published: January 2025

My research critically investigated the emergence of tourism development as a strategy in The Bahamas, the instrumentalization of the industry for planning public space, and the potential for “everyday placemaking” to be a touchstone for public space planning in the nation and the wider Caribbean region. In addition to a literature review and discussion, I conducted interviews, and an observational public space study of the Potter’s Cay Commercial Area from which these watercolours emerged.
The Watched Self
Authors: Patrick Whitney-Ann
Published: January 2025

The Watched Self captures the claustrophobic, surrealist nature of living in a world where surveillance has become the norm. This art piece is part of a broader project entitled, “The Two-Edged Power of Community-Based Surveillance: How the Culture of “Maccoing” and Gossip Can Act as a Deterrent for Devious Behaviour while Perpetuating Paranoia," which examined the physical and technological forms of surveillance within the Caribbean context.
Front Matter
Authors: Editorial
Published: January 2025

Front Matter
Pengaruh Penggunaan Pengontrol Temperatur Pada Alat Pengering Tenaga Surya Terhadap Karakteristik Pengeringan Cengkeh
Authors: Amin Zulkifli , Ridwan Iskandar , Dwika Leonanda Benny
Published: January 2025

Cloves are a spice product when picked have a moisture content of around 70-80% and must be dried before being processed into a product. During the drying process, the drying temperature of the cloves must be kept below 56°C. Farmers generally dry cloves conventionally by drying the cloves under the sun. However, this method requires a long time and unstable temperature. Therefore, it is necessary to develop a dryer with temperature control. The dryer used in this research is a dryer using a solar collector. The temperature of the hot air produced by the solar collector will be controlled by a temperature control device. The control device consists of Arduino as a microcontroller, fan and servo motor as actuators, and thermocouple as a temperature sensor. The main function of the temperature control device is to control the input temperature so that the drying room temperature on shelf 1, shelf 2, shelf 3 does not exceed 50°C during the drying process. In the control device there are 2 fans, fan 1 serves to accelerate the flow of hot air from the collector and fan 2 serves to add environmental air into the drying room. This study was conducted to determine the performance of the temperature control device and changes in the mass of cloves during the drying process. During the test, the temperature control device was able to limit the temperature in the drying room to stay below 50°C and the optimal result was able to reduce from the input temperature of 53.5°C to 43.5°C, 44.5°C and 44.7°C on shelf 1, shelf 2, and shelf 3 in the drying room. The results of this test obtained the highest mass reduction of cloves on shelf 3 with a mass reduction of 40 grams, with a final moisture content of 80%.
Pertimbangan Hukum dalam Penyelesaian Sengketa Proses Pencalonan Peserta Pemilihan Umum di Pengadilan
Authors: Pratiwi Chika Nadia
Published: January 2025

Elections are a pillar of democracy that not only guarantees the political rights of citizens, but also demands consistent and fair implementation of the law. The purpose of this article is to find out about the regulations governing the Election Participant Nomination Process including its resolution in the event of a dispute and its implementation in the PTUN Decision Number 583/G/SPPU/2023/PTUN.JKT. The research method used in this preparation uses the normative legal method, which is carried out by examining literature or secondary data consisting of primary, secondary, and tertiary legal materials. The results of this study are that Law No. 7 of 2017 has regulated the general election process and MA Regulation No. 5 of 2017 concerning the settlement of election process disputes. In its application in 583/G/SPPU/2023/PTUN.JKT, the plaintiff Aditya has fulfilled the requirements as stipulated in Law No. 7 of 2017, but in the dispute resolution process that occurred was not in accordance with MA Regulation No. 5 of 2017. The conclusion is that the plaintiff's lawsuit was rejected because it contradicted the provisions as stipulated in MA Regulation No. 5 of 2017.
Poziom stresu pourazowego, poczucia satysfakcji z życia i satysfakcji seksualnej po porodzie naturalnym, z asystą osoby towarzyszącej i bez niej
Authors: Kardasz Zofia , Szymańska Julia
Published: January 2025

Głównym celem pracy było sprawdzenie poziomu stresu pourazowego u kobiet i ich partnerów po przebyciu porodu naturalnego w jednej z trzech jego okoliczności. Ponadto, celem pracy było również zbadanie satysfakcji z życia z wyszczególnieniem satysfakcji seksualnej partnerów.Badanie zostało przeprowadzone na grupie kobiet i mężczyzn (N=180), którzy zostali rodzicami w wyniku samotnego porodu kobiety, porodu z partnerem lub porodu z inną osobą towarzyszącą niż partner.W pracy wykorzystano następujące narzędzia: Skala Satysfakcji z Życia (SWLS), Skala Wpływu Zdarzeń IES-R, Kwestionariusz Satysfakcji Seksualnej. Do analiz statystycznych wykorzystano jednoczynnikową analizę wariancji dla grup niezależnych oraz test post hoc z poprawką Bonferroniego lub poprawką Gamesa-Howella.Wyniki potwierdziły hipotezy, że samotny poród naturalny jest predyktorem wystąpienia stresu pourazowego u kobiet oraz wpływa na ich poczucie niższej satysfakcji z życia. U mężczyzn natomiast uczestnictwo w porodzie naturalnym z partnerką istotnie wpływa na odczuwanie niższej satysfakcji seksualnej. Hipoteza dotycząca mniejszej satysfakcji z życia u mężczyzn uczestniczących czynnie w porodzie naturalnym potwierdziła się częściowo.Uzyskane wyniki zostały poddane dyskusji z uwzględnieniem zakłóceń, ograniczeń oraz możliwości wykorzystania badań w przyszłości
Komunikacja w rodzinach pochodzenia w koncepcji Modelu Kołowego Davida H. Olsona a samoocena wzrastających w nich młodych dorosłych
Authors: Komorowska-Pudło Marta
Published: January 2025

Zaprezentowane w artykule badania obejmowały kontekst kształtowania samooceny osób wychowywanych w domach o różnych poziomach wzajemnej komunikacji członków rodziny. Celem badawczym było określenie poziomów samooceny ogólnej i samoocen szczegółowych osób dorosłych wzrastających w rodzinach o różnych poziomach spójności, elastyczności i komunikacji. Badania przeprowadzono wśród 252 mężczyzn i 252 kobiet, za pomocą sondażu diagnostycznego, z wykorzystaniem Skal Oceny Rodziny Davida H. Olsona oraz Wielowymiarowego Kwestionariusza Samooceny Edwarda J. O’Brien’a i Seymour Epstein. Badania potwierdzają nikłe i przeciętne poziomy korelacji pomiędzy jakością komunikacji w rodzinach pochodzenia a poziomem samooceny w dorosłości. Z badań wynika, że im bardziej prawidłowa była komunikacja w rodzinach pochodzenia, w ocenie retrospektywnej respondentów, tym wyższy okazał się poziom samooceny młodych dorosłych. Im mniej prawidłowa była ta komunikacja, tym poziom ich samooceny okazywał się niższy. Wnioski z badań prowadzą do postawienia postulatów o zwiększenie zdolności komunikacyjnych rodziców, w efekcie czego kształtowane będą umiejętności komunikowania się wśród ich dzieci oraz wzmocniona zostanie ich samoocena oraz poczucie własnej wartości.
„Nauki o rodzinie” – racja istnienia w świetle społecznych potrzeb XXI wieku
Authors: Żukiewicz Arkadiusz
Published: January 2025

Celem artykułu jest prezentacja dziedziny „nauk o rodzinie” w świetle aktualnych potrzeb społecznych. Zaprezentowany obraz obejmuje potencjał twórczy autonomicznej dziedziny nauki, jakim nauki o rodzinie mogą wzbogacać rzeczywistość życia ludzkiego. W toku badania wybranego przedmiotu poznania wykorzystano metodę desk research. Analiza źródeł oraz literatury przedmiotu objęła kwestie społeczne oraz kwestie rodzinne. Wyniki przeprowadzonych badań umożliwiają udział w dyskursie naukowym dotyczącym racji istnienia dziedziny „nauk o rodzinie”. W artykule zawarto uwagi dotyczące potencjału rozwojowego tej dziedziny nauki. Obejmują sferę teorii oraz praktyki służby rodzinie w realiach XXI wieku.
Cryptocurrencies in the family context: trust, information and financial stability
Authors: Maciejasz Marta , Poskart Robert
Published: January 2025

Background: The rapid rise of cryptocurrencies has sparked debate about their role in the financial system, particularly across generations.
Objectives: This study aimed to identify and explain differences in attitudes towards cryptocurrencies between Generation Z (students) and Generation Y (their parents) in Poland, focusing on trust in the financial system, perceptions of cryptocurrency value, and visions of the future financial landscape.
Methodology: A survey was conducted in June 2023 with 40 students aged 23-24 and one of their parents each (80 total participants). Respondents answered questions about their trust in traditional and crypto finance, views on cryptocurrency potential, and expectations for future financial systems.
Results: Generation Z showed significantly greater openness and trust in cryptocurrencies compared to Generation Y. The younger generation was more likely to view cryptocurrencies as inflation hedges and potential components of future payment systems. Generation Y demonstrated higher trust in the current financial system and fiat currency.
Conclusions: The study reveals substantial intergenerational differences in cryptocurrency perceptions, with implications for financial education, regulation, and innovation. These divergences may shape the future evolution of financial markets and monetary systems.
Comparing Improvements in Biopsy Decision Making with Electrical Impedance Spectroscopy Between US and German Dermatologists
Authors: Zakria Danny , Brownstone Nicholas , Shah Milaan , Burshtein Joshua , DeBusk Lauren , Rosenberg Angela , Rigel Darrell
Published: January 2025

Electrical impedance spectroscopy (EIS) is a noninvasive tool that measures the electrophysical properties of pigmented lesions, generating a score to aid in the differentiation of benign and malignant lesions. This research letter compares two studies, conducted in the United States (US) and Germany, evaluating the impact of EIS on biopsy decision-making among dermatologists. Both studies used the same set of clinical and dermoscopic images along with EIS scores for 49 lesions. Findings revealed that American dermatologists had a higher rate of correct biopsy decisions for malignant melanomas (MMs) and severe dysplastic nevi (SDNs) compared to their German counterparts. However, German dermatologists showed greater accuracy in avoiding unnecessary biopsies of benign pigmented skin lesions (PSLs). The addition of both dermoscopy and EIS significantly improved biopsy decision accuracy for MMs and SDNs in both groups, with EIS further mitigating initial reductions in correct biopsy choices for benign lesions. Differences in practice patterns, training, and malpractice concerns may explain the observed variations between US and German dermatologists. These results underscore the utility of EIS as a complementary tool to dermoscopy, enhancing the accuracy of biopsy decisions and improving patient outcomes.
Analyzing Inpatient Vaccine Reactions Amongst Systemic Lupus Erythematosus Patients in the COVID-19 Era: A National Analysis
Authors: Desai Amar D. , Yeh Jennifer E.
Published: January 2025

Introduction: Systemic lupus erythematosus (SLE) patient hospitalizations were areas of concern during the coronavirus of 2019 (COVID-19) and subsequent vaccine rollout. We aimed to characterize hospitalization trends nationally amongst SLE patients following COVID-19 vaccine rollout.
Methods: The 2016-2020 Nationwide Inpatient Sample (NIS) was queried for SLE hospitalizations using International Classification of Diseases, Tenth Revision (ICD-10) code “M32”. SLE hospitalizations with co-morbid vaccine reactions (RX+) were identified using ICD-10 codes “T50.x”. Clinical and demographic features and rates of high-risk underlying co-morbidities were compared.
Results: Among total SLE hospitalizations, 1.4% were RX+ between 2016-2020. RX+ patient hospitalizations increased from 2019-2020. RX+ patients exhibited a significantly higher burden of heart disease, chronic kidney disease (CKD), chronic liver or lung disease, HIV, and obesity.
Discussion: Our findings suggest that RX+ SLE patients are slightly older, and have significantly greater proportions of comorbid conditions, namely heart disease, CKD, and diabetes compared to RX- SLE patients. Increased SLE severity may impart an inflammatory burden on patients not explained by immunosuppression alone, making them more susceptible to factors with shared pathogenic risks like vaccine reactions.
Lebrikizumab Improves Atopic Dermatitis in Adult and Adolescent Patients With Skin of Color: 16-Week Results From the ADmirable Study
Authors: Alexis Andrew , Moiin Ali , Waibel Jill , Wallace Paul , Cohen David , Laquer Vivian , Kwong Pearl , Reck Atwater Amber , Proper Jennifer , Silk Maria , Pierce Evangeline , Pillai Sreekumar , Rueda Maria Jose , Moore Angela
Published: January 2025

Introduction: Lebrikizumab is a novel monoclonal antibody that binds with high affinity and a slow off-rate to interleukin (IL)-13, thereby blocking the downstream effects of IL13 with high potency. ADmirable (NCT05372419) is an ongoing, open-label, Phase 3b clinical trial of lebrikizumab in patients with moderate-to-severe atopic dermatitis (AD) and skin of color (SoC). These are the first primary results of any Phase 3 clinical trial studying patients with AD and SoC, a historically underrepresented patient population.
Methods: At baseline and Week 2, patients received 500-mg lebrikizumab loading doses followed by 250-mg every 2 weeks through Week 16. Concomitant topical therapy was allowed. Patients receiving protocol-defined rescue therapy were discontinued. Key eligibility criteria included: ≥12 years of age, self-reported race other than White, Fitzpatrick Phototype IV-VI, and moderate-to-severe AD. This study includes new objective measures of pigment such as PDCA-Derm™. Endpoints are summarized as observed (primary analysis) and using non-responder imputation/multiple imputation (NRI/MI; supporting analysis).
Results: At baseline (N=90), patients had a mean (SD) age of 40.7 (19.6) years, AD disease duration of 19.7 (16.1) years, Eczema Area and Severity Index (EASI) of 26.4 (12.2), and Pruritus Numeric Rating Scale (NRS) of 7.0 (2.2). Forty-three percent of patients were female and 16% were adolescent. Most patients had an Investigator’s Global Assessment (IGA) of 3 (69%). Patients self-reported their race as Black/African American (78%), Asian (11%), American Indian/Alaskan Native (7%), and Native Hawaiian or Other Pacific Islander (4%). Patients had Fitzpatrick Phototypes of IV (43%), V (24%), and VI (32%). At Week 16, 69.2% (54/78) of patients achieved a 75% improvement in EASI (NRI/MI, 66.9%), 44.9% (35/78) achieved a 90% improvement in EASI (NRI/MI, 42.5%), 44.9% (35/78) achieved an IGA 0/1 with ≥2-point improvement (NRI/MI, 44.1%), and 58.1% (36/62) reported ≥4-point Pruritus NRS improvement (NRI/MI, 55.4%). Approximately 50% of patients reported itch improvement within 6 weeks. Using PDCA-Derm™, hypopigmentation and hyperpigmentation improved in 33.3% (4/12) and 63.0% (29/46) of patients, respectively (as observed). Most treatment emergent adverse events (TEAE) were mild-to-moderate in severity. No TEAEs lead to discontinuation and no cases of treatment-related conjunctivitis were reported. No serious adverse events were observed.
Conclusion: Lebrikizumab improved signs and symptoms of disease, including post-inflammatory pigment discoloration, in patients with AD and SoC and demonstrated a favorable safety profile.
Lebrikizumab vs Other Systemic Monotherapies for Moderate to Severe Atopic Dermatitis: Network Meta-analysis of Short-term Efficacy
Authors: Silverberg Jonathan , Bieber Thomas , Paller Amy , Kamata Masahiro , Puig Luis , Wiseman Marni , Ezzedine Khaled , Foley Peter , Dossenbach Martin , Akmaz Buelent , Casillas Marta , Karlsson Andrei , Chovatiya Raj
Published: January 2025

Introduction: Treatment options for moderate-to-severe atopic dermatitis (AD) after inadequate response to topical therapy include biologics and Janus Kinase (JAK) inhibitors. A network meta-analysis (NMA) was conducted to evaluate the short-term efficacy of lebrikizumab relative to other monotherapies approved for moderate-to-severe AD in adults and adolescents (≥12 years).
Methods: Data were included from randomized, double-blind, placebo-controlled monotherapy trials of lebrikizumab 250 mg every 2 weeks (Q2W), dupilumab 300 mg Q2W, tralokinumab 300 mg Q2W, abrocitinib 100 or 200 mg daily, baricitinib 2 or 4 mg daily, and upadacitinib 15 or 30 mg daily. Efficacy outcomes included the proportion of patients achieving Eczema Area and Severity Index (EASI) improvement, Investigator Global Assessment of 0 or 1 (IGA 0/1), and ≥4-point improvement in pruritus/itch numeric rating scale (NRS) score at 12 weeks (abrocitinib) or 16 weeks (other treatments). A Bayesian NMA was used to estimate number needed to treat (NNT), odds ratios (ORs), probabilities, and 95% credible intervals (CrI).
Results: Twenty-two monotherapy studies involving 8531 patients were identified. For itch improvement, lebrikizumab had lower NNT values (2.90, 95% CrI: 2.26–3.80) than baricitinib 2 mg (11.12, 6.11–29.30) or 4 mg (8.10, 4.42–19.64) and tralokinumab (7.03, 4.81–11.17). Lebrikizumab had comparable NNT values for itch relative to abrocitinib 100 mg (3.50, 2.67–4.91) or 200 mg (2.31, 1.90–2.93), upadacitinib 15 mg (2.57, 2.09–3.29) or 30 mg (2.02, 1.74–2.46), and dupilumab (3.47, 2.78–4.58). NNT values for IGA 0,1 and EASI response were similar, except that upadacitinib 30 mg QD had lower NNT values than biologics at week 16. In pairwise comparisons, lebrikizumab was statistically superior to baricitinib and tralokinumab and comparable to abrocitinib, dupilumab, and upadacitinib 15 mg across all outcomes. Lebrikizumab had statistically inferior outcomes to upadacitinib 30 mg at week 16.
Conclusion: Lebrikizumab has comparable or better short-term efficacy relative to other biologics and JAK inhibitors, except for upadacitinib 30 mg. Lebrikizumab may be a highly promising first-line biologic for moderate-to-severe AD, offering patients meaningful symptom relief.
Unravelling harpoon nail: Surgical outcome and insights
Authors: Shah Samkit Satish , Zeenat-ul-Firdaus  , Das Joy D. , Shah Yogesh M
Published: January 2025

An ingrown toenail (onychocryptosis) is a chronic, painful condition, especially prevalent among adolescents. A rare variant, termed “harpoon nail,” involves a sharp spike of the nail plate penetrating deep tissue, causing inflammation and granulation tissue formation. Such cases are seldom reported in India, and improper nail cutting is the most common cause. This condition typically affects the hallux, particularly its outer edge, leading to a nail spur that pierces surrounding soft tissues, forming a channel. Factors such as trauma, excessive sweating, and tight shoes can exacerbate the condition by compressing the nail fold against the nail plate, sometimes leading to secondary bacterial infections. Here, we present a unique and rare case of a distal lateral ingrowing toenail-harpoon nail and its surgical management. A 28-year-old Indian female presented with severe pain and swelling in the left hallux for 5 years. Examination revealed hypertrophic soft tissue covering the distal nail plate, which extended 3 mm beyond this tissue. She was diagnosed with a harpoon nail due to hypertrophy of both lateral and distal nail folds. The modified Winograd technique was used for surgical correction and ablation of the germinal matrix was done by radiocautery. The procedure was minimally invasive, quick, and effective, resulting in high patient satisfaction and low recurrence rates. During follow-up visits, the patient reported no difficulty in wearing shoes, and her left hallux appeared normal and healthy, with proper alignment and no nail dystrophy. This case underscores the effectiveness of the modified Winograd technique in managing harpoon nails, providing both functional and cosmetic benefits.
Study on Perception of Medical Students Toward Online and Offline Teaching at Diamond Harbor Government Medical College and Hospital
Authors: Naskar Subhrajyoti , Haldar Debdutta , Chakraborty Sumanta , Paul Bibek
Published: January 2025

Background:

The UNESCO-UNICEF-World Bank Survey on National Education Responses to COVID-19 School Closures collected critical information on how ministries of education in more than 110 countries continued to provide learning opportunities during school closures. As per the record of the MHRD Government of India, more than 32 crores of students have had to suffer from various restrictions since the nationwide lockdown from mid of March 2020. Online education refers to the process of education through the Internet, where students can seek knowledge 24/7 from any corner of the earth without going anywhere physically. Offline education is the traditional counterpart of online education and the original mode of learning that allows students to engage with their peers and teachers in a face-to-face setting on a regular basis.

Objectives:

In this context, we intended to carry out a study on the perception of medical students of Diamond Harbor Government Medical College and Hospital (DHGMCH) toward online and offline teaching and to find out the sociodemographic profile of the study participants which constituted the first batch of DHGMCH.

Material and Methods:

This is an Observational, descriptive study, Cross-sectional in design, conducted at Diamond Harbor Government Medical College and Hospital from July 11, 2022, to August 1, 2022.

Results:

According to our study total number of participants were 82 out of which there were 63.4 % male 36.6% female. Majority of the participants (85.4%) found offline classes are interactive. As we found from our study population, majority of the participants (85.4%) want interactive offline classes. In our study, majority of the participants (89%) prefer opportunity of practical classes followed by facility of group discussions (72%).

Conclusion:

It reveals that most of the students found offline classes are interactive. It shows that in online education, most of the students preferred interactive ways of online education. In offline education, the students have the major advantage of attending practical classes, followed by group discussions and one-to-one interaction with teachers. It reveals that in online education, the majority of students found no need to travel as a major advantage, followed by having flexible study locations and hours as well as having the ability to learn at their own pace. Although e-learning has opened a plethora of opportunities for learning among students, it can never completely replace offline classroom teaching.
PENGARUH KOMUNIKASI RISIKO DAN SIKAP MASYARAKAT TERHADAP MITIGASI BENCANA SEMBURAN GAS DI KOTA PEKANBARU
Authors: Hanshardi Muhammad
Published: January 2025

Permasalahan lingkungan dan komunikasi saling terkait dan memiliki dampak yang signifikan satu sama lain. Komunikasi memainkan peran penting dalam cara kita memahami, menyampaikan, dan menanggapi isu-isu lingkungan.Mengingat risiko yang bisa ditimbulkan oleh suatu bencana bukan saja dalam bentuk kerugian harta benda, tapi juga kerusakan lingkungan dan korban jiwa. Tujuan utama dari komunikasi risiko untuk meningkatkan pemahaman, kesadaran, dan persiapan individu atau masyarakat terhadap risiko yang ada. Tujuan dari studi ini untuk menganalisis pengaruh komunikasi risiko dan sikap masyarakat terhadap mitigasi bencana di Kota Pekanbaru. Penelitian ini adalah penelitian kuantitatif yang melibatkan 375 responden. Hasil penelitian ini menunjukkan bahwa hasil uji parsial variabel komunikasi risiko terhadap mitigasi bencana adalah  sig. 0,011< 0,05 yang mana variabel komunikasi risiko berpengaruh terhadap mitigasi bencana. Pada uji parsial variabel sikap masyarakat tidak mempengaruhi mitigasi bencana, hal ini disebabkan hasil uji parsial pada variabel ini adalah sig. 0,133 > sig.0,05. Berdasarkan hasil uji simultan atau uji F yang dilakukan memiliki pengaruh antara  pada variabel bebas secara bersamaan terhadap variabel terikat adalah sebesar 3,292 yang mana nilai pada uji F lebih besar dibanding uji t tabel yakni 0,098.
 
Kata Kunci: Komunikasi Risiko, Sikap Masyarakat, Bencana Semburan Gas Alam, Kota Pekanbaru.
Analisis Keakraban Pertemanan Mahasiswa Baru dan Pertemanan Mahasiswa Tingkat Atas Pada Mahasiswa Ilmu Komunikasi Universitas Singaperbangsa Karawang (UNSIKA)
Authors: Radja Khaharudin Syah  , Fitriani  , Rosy Fitriyah  , Verent Putri K.M  , Nurani Masyita
Published: January 2025

Penelitian ini berjudul "Analisis Keakraban Pertemanan Mahasiswa Baru dan Pertemanan Mahasiswa Tingkat Atas pada Mahasiswa Ilmu Komunikasi Universitas Singaperbangsa Karawang (UNSIKA)" bertujuan untuk menganalisis tingkat keakraban pertemanan antara mahasiswa baru dan mahasiswa tingkat atas serta menganalisis faktor-faktor yang mempengaruhi perbedaan tersebut. Teori Penetrasi Sosial dan Teori Fenomenologi digunakan untuk memahami dinamika hubungan sosial di lingkungan akademis. Metode penelitian yang digunakan adalah studi kasus, fenomenologi, dan deskriptif. Hasil penelitian ini menunjukkan bahwa mahasiswa baru lebih eksploratif dalam pertemanan, sedangkan mahasiswa tingkat akhir lebih selektif dan fokus pada kualitas hubungan.