bluuebunny/crossref_metadata_2025 huggingface dataset:
Sakralne i ludyczne symbole szczygła w języku i kulturze
Authors: Masłowska Ewa
Published: May 2022

SACRED AND LUDIC SYMBOLS OF A GOLDFINCH IN LANGUAGE AND CULTURE
The article is dedicated to symbolic representations of szczygieł (a goldfinch) in Polish language and culture, taking into account the European cultural background. The author presents the process of symbolization of the sacred and ludic profile of a goldfinch as a representative of avifauna based on linguistic data (etymology, phrasematics), text data (literature and folklore), as well as on iconography. References to Western European painting made it possible for the author to present the multiple layers of a goldfinch symbolism and related differences in the way of imaging, developing connotations and conceptualization of symbolic contents. The sacred imagery was dominated by Biblical associations, while in ludic images there was a tendency to present birds as autotelic beings without strictly religious connotations.
Los captadores de la atención: creadores de contenido ante las lógicas de las plataformas digitales
Authors: Villegas Simón Isabel
Published: May 2022

Los creadores de contenido digital han revolucionado la producción y el consumo mediático y de entretenimiento; además, se han erigido como nuevas modalidades de trabajadores creativos asociados a la expansión del poder cultural, tecnológico, económico y social de las plataformas digitales. En este texto se propone una revisión bibliográfica de los principales conceptos, modelos teóricos e investigaciones que han explicado y categorizado las prácticas y experiencias de los creadores de contenido digital y, en particular, su relación con las plataformas digitales para las que trabajan como captadores de atención. Los principales conceptos se enmarcan en tres apartados: la relación entre visibilidad y atención; las estrategias de visibilidad y supervivencia de los creadores de contenido digital, y las experiencias de precariedad y problemas emocionales y psicológicos que sufren los creadores digitales. Finalmente, se sugieren un conjunto de propuestas que pueden guiar futuras líneas de investigación con base en algunas tendencias actuales del fenómeno vinculadas a la potencial consolidación del sector profesional y creativo formado por los creadores de contenido digital y también a la identificación de carencias en la literatura científica generada hasta el momento.
UPAYA PEMBERANTASAN RENTENIR DI DUSUN SOKA, NGORO ORO GUNUNG KIDUL
Authors: Nursulistiyo Eko , Mahendra Karunia Ardhi
Published: May 2022

Rentenir adalah sebuah praktek pemberian pijaman kepada seseorang dengan memberikan bunga yang tinggi. Rentenir hukumnya haram dalam Islam dan harus diberantas. Praktek rentenir ini di Dusun Soka Ngoro oro Gunung Kidul masih ditemukan. KKN UAD yang diterjunkan ke dusun Soka mempunyai kegiatan tematik yaitu berupa pemberantasan rentenir. Kegiatan utama pemberantasan rentenir dilaksanakan dengan penyuluhan manajemen keuangan keluarga, peyuluhan dan penanaman tanaman obat keluarga (TOGA), dan pelatihan pembuatan nugget lele. Tujuan dari keseluruhan program ini adalah untuk meningkatkan kesadaran masyarakat mengenai bahaya riba/rentenir dan meningkatkan skill masyarakat sehingga perekonomian mereka meningkat. Dampak kegiatan ini adalah kesadaran masyarakat meningkat tentang bahaya rentenir dan hukum Islam mengenai rentenir, peningkatan kesehatan masyarakat dan pengetahuan masyarakat mengenai pemanfaatan, komersialisasi, dan penggunaan tanaman obat, dan peningkatan skill warga masyarakat mengenai pembuatan nugget lele yang bahan bakunya melimpah di dusun Soka. Diharapkan program tersebut dapat meningkatkan perekonomian masyarakat dan menghapus rentenir secara bertahap di dusun Soka.
UPAYA PENINGKATAN KEMANDIRIAN EKONOMI KELUARGA MELALUI PEMBUATAN SYRUP KUNYIT ASAM SERTA PERIJINAN USAHANYA
Authors: Rahman Asep Abdul , Aji Nur , Herdiana Irvan
Published: May 2022

Memasuki era globalisasi, kesenjangan taraf kesejahteraan merupakan hal yang utama harus dicegah, karena kesempatan yang muncul dari ekonomi terbuka hanya dapat dimanfaatkan oleh wilayah, sektor atau golongan yang lebih maju. Berdasarkan permasalahan yang ada pada tahun sebelumnya, maka pada tahun 2019 akan dibuat minuman siap saji berupa sirup kunyit asam. Hal ini untuk menjawab permasalahan dari pengabmas yang dilakukan pada tahun 2017. Metode yang digunakan yaitu dengan melakukan pendampingan kepada masyarakat melalui transfer ilmu melalui penyuluhan serta demonstrasi. Khalayak sasaran dari Program Pengabdian Masyarakat adalah Masyarakat Kelurahan Kahuripan, yang merupakan masyarakat tidak produktif secara ekonomis. Pada hakekatnya, kegiatan ini solusi terhadap permasalahan yang dihadapi mitra melalui pendekatan secara terpadu, agar dapat meningkatkan taraf perekenomian masyarakat. Dari hasil kegiatan inidi Kelurahan Kahuripan Kecamatan Tawang, Kota Tasikmalaya periode tahun 2019 telah berhasil dilaksanakan dengan luaran: tingkat pengetahuan mayarakat bertambah dalam hal pembuatan produk kunyit asam, tata cara permohonan ijin Pangan Industri Rumah Tangga dan Izin Usaha Mikro Kecil. Selain itu masyarakat dapat membuat produk sirup kunyit asam yang dapat diterima oleh konsumen.
PARENTING ISLAMI BAGI KAUM IBU-IBU MILENIAL DI DESA TEMUWUH KECAMATAN DLINGO KABUPATEN BANTUL YOGYAKARTA
Authors: Sutarman Sutarman , Pertiwi Swastika Tri , Akbar M. Ilham , Aprilianto Dedy
Published: May 2022

Tujuan Program pelatihan ini, adalah untuk memberikan pemahaman dan edukasi kepada ibu-ibu milenial di Dusun Nglampengan, Salam, dan Temuwuh desa Temuwuh Kecamatan Dlingo Kabupaten Bantul tentang bagaimana mendidik anak-anak yang baik secara Islami; bagaimana orang tua Â memiliki motivasi kuat agar anaknya memiliki semangat belajar tinggi dalam menempuh pendidikan sehingga menjadi generasi yang religius, kuat dan berakater serta memiliki integritas. Metode yang digunakan dalam program pelatihan: Â â€œParenting Islami untuk Kaum Ibu-ibu Millenialâ€ di desa Temuwuh ini adalah dengan metode â€œCooperatif Learningâ€, dengan pendekatan FGD (Forum Group Discussion) terhadap masyarakatâ€ serta Â tanya jawab. Hasil dari pelatihan ini adalah bahwa mereka paham akan materi yang disampaikan, dan peserta merasa diuntungkan karena mendapat ilmu atau pengetahuan baru yang sebelumnya belum mereka dapatkan yaitu pengetahuan dalam mendidik anak secara baik yang Islami, orangtua termotivasi untuk membimbing pendidikan anak setinggi-tingginya dan adanya kesadaran orang tua dalam menjaga dan merawat keluarga(anak-anaknya) dari perilaku amoral (pergaulan bebas). Dampak dari pelatihan ini, yaitu anak-anak yang mengaji lebih banyak dibandingkan dengan biasanya. Masyarakat juga tertanam semangat untuk menyekolahkan anaknya hingga ke pendidikan pada jengjang yang lebih tinggi. Selain itu masyarakat yang datang di pengajian rutin setiap malam Rabu juga lebih banyak dari biasanya. Serta Â adanya tranformasi orang tua timbul kesadaran dalam menjaga dan merawat keluarga(anak-anaknya) dari perilaku amoral (pergaulan bebas).Â
PKM GEO UMKM DESA KENONGO
Authors: Latifah Fitri Nur , Maika M. Ruslianoor , Ariyanti Novia
Published: May 2022

Sesuai dengan peta jalan Industri 4.0 yang telah dibuat Kementrian Perindustrian Republik Indonesia atau lebih dikenal dengan sebutan making Indonesia 4.0, yang dijadikan suatu landasan pertumbuhan ekonomi Indonesia dimasa mendatang, perananan teknologi dalam pengembangan UMKM saat ini tidak bisa dipandang hal yang remeh lagi. Permasalahan UMKM sangatlah komplek dan salah satunya adalah pemasaran (marketshare) UMKM itu sendiri, sehingga kami berupaya membuat sebuah direktori UMKM Desa Kenongo yang membantu UMKM dalam memasarkan produknya. Desa Kenongo adalah salah satu desa di kabupaten Sidoarjo dengan jumlah UMKM sekitar 80 UMKM. Metode pelaksanaan yang dipakai dalam melakukan kegiatan ini adalah melakukan survei atas beberapa UMKM, mengelompokkan UMKM berdasarkan jenis usaha mitra, membuat database mitra termasuk koordinat lokasi usaha mitra, dan membuat database/direktori online yang bisa diakses oleh pihak umum. Direktori ini nantinya sangat berdampak positif bagi pengembangan UMKM Desa Kenongo dimasa mendatang.
PELATIHAN PENGAWAS KOPERASI SYARIAH BERSERTIFIKASI DI DAERAH ISTIMEWA YOGYAKARTA
Authors: Wahyudi Rofiul , Riduwan Riduwan , Rifan Akhmad Arif
Published: May 2022

Dewan Pengawas Syariah (DPS) di Koperasi Simpan Pinjam dan Pembiayaan Syariah (KSPPS) yang bersertifikasi jabatan pengawas syariah menjadi kebutuhan yang mendesak. Hal ini disebabkan terbatasnya jumlah DPS yang bersertifikasi di lembaga keuangan mikro syariah. Oleh karena itu, kegiatan ini bertujuan memberikan pelatihan sebagai bekal bagi Dewan Pengawas Syariah di Daerah Istimewa Yogyakarta dalam menjalankan tugas dan wewenangnya. Metode pelatihan ini menggunakan klasikal dengan menerapkan kombinasi metode: ceramah, diskusi dan role play. Hasil pelatihan menunjukkan bahwa adanya peningkatan pemahaman DPS terhadap aspek kesyariahan.Â
PEMBANGUNAN DAN PELATIHAN CONTENT MANAGEMENT SYSTEM BERBASIS WEBSITE SMART KIDS COLLEAGUE
Authors: Puspitasari Fransiska Hernina , Wibisono Y Priadi , Wardhana D Yidistya
Published: May 2022

Manusia membutuhkan suatu pendidikan untuk mengasah keterampilan dalam memenuhi kebutuhan sehari-hari, baik dalam dunia usaha atau pun industri. Pendidikan tersebut dapat diperoleh melalui pendidikan formal maupun non-formal. Data statistik kementerian pendidikan dan kebudayaan Daerah Istimewa Yogyakarta (DIY) menunjukkan jumlah pendidikan non formal tahun 2018 sejumlah 433. Pendidikan non-formal melalui pendidikan ketrampilan telah menunjukkan kontribusi positif terhadap penurunan angka kemiskinan dalam pembangunan pedesaan. Smart Colleague hadir sebagai salah satu dari pendidikan non formal di Yogyakarta untuk memberikan pendukung pendidikan komputer sejak usia dini. Di tengah peluang yang menjanjikan ini belum banyak pelaku bisnis pendidikan non formal yang memanfaatkan teknologi informasi sebagai sarana promosi dan informasi. Berawal dari keterbatasan pengetahuan akan teknologi informasi inilah konsep pengabdian pada masyarakat ini disusun. Kegiatan pengabdian masyarakat ini membantu Lembaga Pendidikan Non Formal dengan sampel satu mitra, yaitu Smart Colleague yang bergerak di bidang pelatihan komputer yang fokus mengembangkan edu-games, baik untuk pra-sekolah, Siswa SD, dan juga dewasa. Kegiatan ini dilakukan dalam jangka waktu enam bulan. Tujuan dari kegiatan ini adalah memberikan pelatihan kepada relawan dan pengajar di Smart Colleague agar dapat memanfaatkan teknologi informasi untuk mempromosikan jasanya. Teknologi informasi yang digunakan adalah sistem informasi website.
OPTIMALISASI SISTEM INFORMASI DALAM MENINGKATKAN PELAYANAN PUBLIK
Authors: Sakir Sakir , Rahmatullah Azam Syukur , Sarofah Riska
Published: May 2022

Kegiatan pemberdayaan sosial dilakukan dengan dua kegiatan utama yaitu pembuatan profil desa dan Penguatan Sistem Informasi Desa (SID) di Klaster Temanggung, Jetis Saptosari, Kabupaten Gunung Kidul. Potensi yang dimiliki oleh dusun harus bisa menjadi identitas perkembangan kemajuan desa. Metode yang digunakan adalah membantu dan melibatkan mahasiswa Universitas Muhammadiyah Yogyakarta untuk langsung terjun ke lapangan dan menyusun profil dusun dan pembuatan situs web serta pelatihan untuk mewujudkan sumber daya manusia yang handal. Output yang dihasilkan dari layanan masyarakat meliputi Pertama, Temanggung memiliki buku profil dengan edisi terbaru dan dengan penambahan informasi yang diperlukan. Kedua, Temanggung memiliki situs web yang berisi informasi dusun dan desa. Pengembangan yang perlu dilakukan setelah program termasuk memperbarui profil desa dan menggunakan media sosial dalam penyediaan layanan selain situs web yang telah dibuat oleh komunitas pemberdayaan.
An exploration of setting healthy personal boundaries as a veterinary professional – part 1: at work and beyond
Authors: Green Krissy
Published: May 2022

A personal boundary is a behavioural or emotional metaphorical wall that we erect to ensure our physical and psychological safety. These are important for keeping us in healthy and sustainable relationships. We draw personal boundaries to protect what is uniquely ours: our body, resources, intellect, emotions and behaviour. Therefore, where we draw them is specific to us based on our ethics, values, priorities, experiences, feelings and needs. Veterinary professionals may struggle to set boundaries because they may be driven by compassion or empathy, or have perfectionistic or people-pleasing tendencies. This is the first of a series of two articles addressing what personal boundaries are and why we need them. Why veterinary professionals struggle to set healthy boundaries is also discussed.
Fraseologia dell’algherese: risorse e nuovi impulsi per la fraseografia e la fraseodidattica di una varietà linguistica minoritaria italiana
Authors: Autelli Erica , Caria Marco
Published: May 2022

The Catalan of Alghero is poorly documented at a lexicographic level, and the number of phrasemes to be found in the dictionaries is small. So, where can such word combinations be found and how can they be included in dictionaries? The present article aims to answer these two questions, giving a first overview of the phraseography of diatopic varieties in Italy, followed by information on Algherese and the description of possible resources from which the relevant information could be drawn. This is followed by a sociolinguistic investigation showing the complexity of the topic and a few divergencies from Italian, of which one should take account in the phraseodidactics of Algherese.
Computational optical system design: a global optimization method in a
simplified imaging system
Authors: Li Jiangyong , Zhao Lin , Wu Xiaoqin , Liu Fei , Wei Yazhe , Yu Chun , Shao Xiaopeng
Published: May 2022

An optical imaging system often has problems of high complexity and low energy
transmittance to compensate for aberrations. Here we propose a method
to correct aberrations by coupling an optical subsystem with a digital
subsystem. Specifically, in the global optimization process, the two
subsystems correct their respective, easily handled aberrations so
that the final imaging aberration is minimized. We design simple
lenses with this method and assess imaging quality. In addition, we
conduct a tolerance analysis for the proposed method and verify the
effectiveness of deconvolution using a spatially varying point spread
function (SVPSF) in the actual imaging process. Simulation results
show the superiority of the proposed method compared with the
conventional design and the feasibility of simplifying the optical
system. Experimental results prove the effectiveness of deconvolution
using SVPSF.
Computed tomography in resolving flame topology with internal optical
blockage involved
Authors: Wu Haifeng , Gao Yu , Wu Yue , Gong Bugao , Ling Chen
Published: May 2022

This work reports the modification and optimization of a computed tomography (CT)
algorithm to become capable of resolving an optical field with
internal optical blockage (IOB) present. The
IOB—practically, the opaque mechanical parts installed
inside the measurement domain—prevents a portion of emitted
light from transmitting to optical sensors. Such blockage disrupts the
line-of-sight intensity integration on recorded projections and
eventually leads to incorrect reconstructions. In the modified
algorithm developed in this work, the positions of the obstacle are
measured a priori, and then the
discretized optical fields (i.e., voxels) are classified as those that
participate in the CT process (named effective voxels) and those that
are expelled, based on the relative positions of the imaging sensors,
IOB, and light signal distribution. Finally, the effective voxels can
be iteratively reconstructed by combining their projections on sensors
that provide direct observation. Moreover, the impact of IOB on
reconstruction accuracy is discussed under different sensor
arrangements to provide hands-on guidance on sensor orientation
selection in practical CT problems. The modified algorithm and sensor
arrangement strategy are both numerically and experimentally validated
by simulated phantoms and a two-branch premixed laminar flame in this
work.
Networks of necessity: Simulating COVID-19 mitigation strategies for disabled people and their caregivers
Authors: Valles Thomas E. , Shoenhard Hannah , Zinski Joseph , Trick Sarah , Porter Mason A. , Lindstrom Michael R.
Published: May 2022

A major strategy to prevent the spread of COVID-19 is the limiting of in-person contacts. However, limiting contacts is impractical or impossible for the many disabled people who do not live in care facilities but still require caregivers to assist them with activities of daily living. We seek to determine which interventions can best prevent infections of disabled people and their caregivers. To accomplish this, we simulate COVID-19 transmission with a compartmental model that includes susceptible, exposed, asymptomatic, symptomatically ill, hospitalized, and removed/recovered individuals. The networks on which we simulate disease spread incorporate heterogeneity in the risk levels of different types of interactions, time-dependent lockdown and reopening measures, and interaction distributions for four different groups (caregivers, disabled people, essential workers, and the general population). Of these groups, we find that the probability of becoming infected is largest for caregivers and second largest for disabled people. Consistent with this finding, our analysis of network structure illustrates that caregivers have the largest modal eigenvector centrality of the four groups. We find that two interventions—contact-limiting by all groups and mask-wearing by disabled people and caregivers—most reduce the number of infections in disabled and caregiver populations. We also test which group of people spreads COVID-19 most readily by seeding infections in a subset of each group and comparing the total number of infections as the disease spreads. We find that caregivers are the most potent spreaders of COVID-19, particularly to other caregivers and to disabled people. We test where to use limited infection-blocking vaccine doses most effectively and find that (1) vaccinating caregivers better protects disabled people from infection than vaccinating the general population or essential workers and that (2) vaccinating caregivers protects disabled people from infection about as effectively as vaccinating disabled people themselves. Our results highlight the potential effectiveness of mask-wearing, contact-limiting throughout society, and strategic vaccination for limiting the exposure of disabled people and their caregivers to COVID-19.
Biology and engineering of integrative and conjugative elements: Construction and analyses of hybrid ICEs reveal element functions that affect species-specific efficiencies
Authors: Bean Emily L. , Herman Calvin , Anderson Mary E. , Grossman Alan D.
Published: May 2022

Integrative and conjugative elements (ICEs) are mobile genetic elements that reside in a bacterial host chromosome and are prominent drivers of bacterial evolution. They are also powerful tools for genetic analyses and engineering. Transfer of an ICE to a new host involves many steps, including excision from the chromosome, DNA processing and replication, transfer across the envelope of the donor and recipient, processing of the DNA, and eventual integration into the chromosome of the new host (now a stable transconjugant). Interactions between an ICE and its host throughout the life cycle likely influence the efficiencies of acquisition by new hosts. Here, we investigated how different functional modules of two ICEs, Tn916and ICEBs1, affect the transfer efficiencies into different host bacteria. We constructed hybrid elements that utilize the high-efficiency regulatory and excision modules of ICEBs1and the conjugation genes of Tn916. These elements produced more transconjugants than Tn916, likely due to an increase in the number of cells expressing element genes and a corresponding increase in excision. We also found that several Tn916and ICEBs1components can substitute for one another. UsingB.subtilisdonors and threeEnterococcusspecies as recipients, we found that different hybrid elements were more readily acquired by some species than others, demonstrating species-specific interactions in steps of the ICE life cycle. This work demonstrates that hybrid elements utilizing the efficient regulatory functions of ICEBs1can be built to enable efficient transfer into and engineering of a variety of other species.
Local chromatin context regulates the genetic requirements of the heterochromatin spreading reaction
Authors: Greenstein R. A. , Ng Henry , Barrales Ramon R. , Tan Catherine , Braun Sigurd , Al-Sady Bassem
Published: May 2022

Heterochromatin spreading, the expansion of repressive chromatin structure from sequence-specific nucleation sites, is critical for stable gene silencing. Spreading re-establishes gene-poor constitutive heterochromatin across cell cycles but can also invade gene-rich euchromatinde novoto steer cell fate decisions. How chromatin context (i.e. euchromatic, heterochromatic) or different nucleation pathways influence heterochromatin spreading remains poorly understood. Previously, we developed a single-cell sensor in fission yeast that can separately record heterochromatic gene silencing at nucleation sequences and distal sites. Here we couple our quantitative assay to a genetic screen to identify genes encoding nuclear factors linked to the regulation of heterochromatin nucleation and the distal spreading of gene silencing. We find that mechanisms underlying gene silencing distal to a nucleation site differ by chromatin context. For example, Clr6 histone deacetylase complexes containing the Fkh2 transcription factor are specifically required for heterochromatin spreading at constitutive sites. Fkh2 recruits Clr6 to nucleation-distal chromatin sites in such contexts. In addition, we find that a number of chromatin remodeling complexes antagonize nucleation-distal gene silencing. Our results separate the regulation of heterochromatic gene silencing at nucleation versus distal sites and show that it is controlled by context-dependent mechanisms. The results of our genetic analysis constitute a broad community resource that will support further analysis of the mechanisms underlying the spread of epigenetic silencing along chromatin.
Assessing the attitude and problem-based learning in mathematics through PLS-SEM modeling
Authors: Zamir Samina , Yang Zhang , Wenwu Hao , Sarwar Uzma
Published: May 2022

Mathematics plays a leading part in day-to-day life and has enhanced a necessary component for human accomplishments. Students from many countries do not reach the expected level in mathematics. Therefore, it is essential to pay close consideration to the causes related to ability in mathematics. Mathematics attitude is considered as one of the critical variables in the process of mathematics learning. This study aimed to determine students’ attitudes and achievements through problem-based learning in mathematics. The selected study group contained 600 students and 35 teachers from rural public secondary schools in District Rawalpindi, Pakistan. The data collection was done using questionnaires from students and teachers and collected data analyzed by SPSS 23 and Amos 23. This study’s result was carried out using Partial Least square structural equation Model (PLS-SEM), descriptive analysis, and hypotheses testing. The outcomes in this study indicated that the mean fluctuated between 1 to 4.5, 3.71 to 4.20, and Std. Deviation fluctuated between 0.6 to 2.0 and 0.75 to 1.55 in the students and teacher models, respectively. The results of the PLS-SEM students’ model show a negative attitude towards mathematics. The teachers’ PLS-SEM model showed the Effects of using problem-based learning (PBL) on students’ achievements. According to the hypotheses testing, the acceptance of hypotheses by stating that the Confidence in Learning Mathematics Scale (C), Value of Mathematics Scale (V), and Student Mathematics Motivation Scale (M) are significant effects for the Students’ Attitude Toward Problem-Based Learning (ATPBL). But the Attitude Toward Enjoyment in Mathematics Scale (AE) was rejected, and it did not significantly affect the ATPBL. As well as, the Problem-solving learning and students’ achievement (PLA), Advantages of problem-solving learning (APL) and Difficulties in using problem-solving learning (DPL) have a significant positive effect on the ATPBL. Finally, this study suggested that teachers also adopt new teaching methods corresponding to mathematics, and there is a need to explore particular mathematics skills to enhance students’ learning abilities.
Antioxidant properties of bee propolis and an important component, galangin, described by X-ray crystal structure, DFT-D and hydrodynamic voltammetry
Authors: Caruso Francesco , Berinato Molly , Hernandez Melissa , Belli Stuart , Smart Christopher , Rossi Miriam
Published: May 2022

Propolis is produced by honeybees and used to seal their hives for defensive purposes and has been used in ethnopharmacology since ancient times. It is a lipophilic material containing a large collection of naturally produced plant organic molecules, including flavonoids. The flavonoid galangin is consistently found in propolis, independent of the hive geographical location and its X-ray crystal and molecular structure is reported. The antioxidant scavenging of superoxide by galangin and propolis is here presented. Using a cyclic voltammetry technique developed in our lab, we show that galangin is an excellent scavenger of the superoxide radical, perhaps even better than quercetin. Our results show that galangin displays a Superoxide Dismutase (SOD) function. This is described experimentally and theoretically (DFT). Two modes of scavenging superoxide are seen for galangin: (1) superoxide radical extraction of H atom from the hydroxyl moieties located in position 3 and 5 of galangin, which are also associated with proton incorporation defining the SOD action; (2) π-π interaction among several superoxide radicals and the galangin polyphenol ring that evolve towards release of O2 and H2O2. We describe these two actions separately as their relative sequence, and/or combination, cannot be defined; all these processes are thermodynamically spontaneous, or subjected to mild barriers.
Improving object detection quality with structural constraints
Authors: Rong Zihao , Wang Shaofan , Kong Dehui , Yin Baocai
Published: May 2022

Recent researches revealed object detection networks using the simple “classification loss + localization loss” training objective are not effectively optimized in many cases, while providing additional constraints on network features could effectively improve object detection quality. Specifically, some works used constraints on training sample relations to successfully learn discriminative network features. Based on these observations, we propose Structural Constraint for improving object detection quality. Structural constraint supervises feature learning in classification and localization network branches with Fisher Loss and Equi-proportion Loss respectively, by requiring feature similarities of training sample pairs to be consistent with corresponding ground truth label similarities. Structural constraint could be applied to all object detection network architectures with the assist of our Proxy Feature design. Our experiment results showed that structural constraint mechanism is able to optimize object class instances’ distribution in network feature space, and consequently detection results. Evaluations on MSCOCO2017 and KITTI datasets showed that our structural constraint mechanism is able to assist baseline networks to outperform modern counterpart detectors in terms of object detection quality.
Cross-sectional survey of parental barriers to participation in pediatric participant research registries
Authors: Slotkowski Rebecca A. , Delair Shirley F. , Neemann Kari A.
Published: May 2022

Research registries are a powerful tool for boosting recruitment into clinical trials. However, little is known about how parents approach the decision to enroll their child in a pediatric participant research registry (PPRR). We conducted in-person, written, or telephone surveys with parents/guardians of children hospitalized at Children’s Hospital of Omaha, Nebraska to identify attitudes towards and barriers to enrollment in PPRRs. Overall, our population (N = 36) had positive attitudes toward PPRRs, with 77.8% (CI: 61.6, 88.4) of participants stating they were “somewhat” or “very” likely to enroll their child. Likelihood to enroll differed between various recruitment and enrollment methods, with participants stating they would be more likely to enroll their child in a PPRR if they were recruited by their child’s primary care provider or a nurse in clinic (p = 0.02) and less likely to enroll if they were recruited through social media (p<0.001). Additionally, over 90% of participants who were likely to enroll their child in a PPRR (N = 28) were also willing to provide demographic, medical, and lifestyle information. However, these participants remained concerned about inappropriate sharing of their information with insurance or for-profit companies (53.6%, CI: 35.8, 70.4) and about receiving unwanted telephone calls from the registry (78.6%, CI: 60.0, 90.0). Parents are generally willing to enroll their child in a PPRR. However, to optimize enrollment, investigators must understand parental preferences for and concerns surrounding enrollment in a PPRR.
Developing predictive hybridization models for phosphorothioate oligonucleotides using high-resolution melting
Authors: Wang Siyuan S. , Xiong Erhu , Bhadra Sanchita , Ellington Andrew D.
Published: May 2022

The ability to predict nucleic acid hybridization energies has been greatly enabling for many applications, but predictive models require painstaking experimentation, which may limit expansion to non-natural nucleic acid analogues and chemistries. We have assessed the utility of dye-based, high-resolution melting (HRM) as an alternative to UV-Vis determinations of hyperchromicity in order to more quickly acquire parameters for duplex stability prediction. The HRM-derived model for phosphodiester (PO) DNA can make comparable predictions to previously established models. Using HRM, it proved possible to develop predictive models for DNA duplexes containing phosphorothioate (PS) linkages, and we found that hybridization stability could be predicted as a function of sequence and backbone composition for a variety of duplexes, including PS:PS, PS:PO, and partially modified backbones. Individual phosphorothioate modifications destabilize helices by around 0.12 kcal/mol on average. Finally, we applied these models to the design of a catalytic hairpin assembly circuit, an enzyme-free amplification method used for nucleic acid-based molecular detection. Changes in PS circuit behavior were consistent with model predictions, further supporting the addition of HRM modeling and parameters for PS oligonucleotides to the rational design of nucleic acid hybridization.
Epitope-focused immunogen design based on the ebolavirus glycoprotein HR2-MPER region
Authors: Schoeder Clara T. , Gilchuk Pavlo , Sangha Amandeep K. , Ledwitch Kaitlyn V. , Malherbe Delphine C. , Zhang Xuan , Binshtein Elad , Williamson Lauren E. , Martina Cristina E. , Dong Jinhui , Armstrong Erica , Sutton Rachel , Nargi Rachel , Rodriguez Jessica , Kuzmina Natalia , Fiala Brooke , King Neil P. , Bukreyev Alexander , Crowe James E. , Meiler Jens
Published: May 2022

The three human pathogenic ebolaviruses: Zaire (EBOV), Bundibugyo (BDBV), and Sudan (SUDV) virus, cause severe disease with high fatality rates. Epitopes of ebolavirus glycoprotein (GP) recognized by antibodies with binding breadth for all three ebolaviruses are of major interest for rational vaccine design. In particular, the heptad repeat 2 –membrane-proximal external region (HR2-MPER) epitope is relatively conserved between EBOV, BDBV, and SUDV GP and targeted by human broadly-neutralizing antibodies. To study whether this epitope can serve as an immunogen for the elicitation of broadly-reactive antibody responses, protein design in Rosetta was employed to transplant the HR2-MPER epitope identified from a co-crystal structure with the known broadly-reactive monoclonal antibody (mAb) BDBV223 onto smaller scaffold proteins. From computational analysis, selected immunogen designs were produced as recombinant proteins and functionally validated, leading to the identification of a sterile alpha motif (SAM) domain displaying the BDBV-HR2-MPER epitope near its C terminus as a promising candidate. The immunogen was fused to one component of a self-assembling, two-component nanoparticle and tested for immunogenicity in rabbits. Robust titers of cross-reactive serum antibodies to BDBV and EBOV GPs and moderate titers to SUDV GP were induced following immunization. To confirm the structural composition of the immunogens, solution NMR studies were conducted and revealed structural flexibility in the C-terminal residues of the epitope. Overall, our study represents the first report on an epitope-focused immunogen design based on the structurally challenging BDBV-HR2-MPER epitope.
Downplay social justice issues in art education
Authors: Pariser David
Published: May 2022

From your perspective, what is the place of social justice education (and politics) in the art classroom? Are these topics a distraction from the disciplinary content of visual arts education, as you understand it? From your perspective, what is the disciplinary content of art education?
Isolation of Nanocellulose from Aquatic Wetland Plant-Eleocharis dulcis
Authors: Sunardi S. , Istikowati W.T. , Sari D.I. , Yanto D.H.Y. , Kamari A.
Published: May 2022

Eleocharis dulcis is a sustainable wetland material available in enormous quantities in Kalimantan,
Indonesia. This study aimed to evaluate the suitability of the acid hydrolysis method for the isolation
of nanocellulose of E. dulcis. The isolation process started with delignification, followed by the removal
of hemicellulose to produce cellulose. The hydrolysis was performed at 45 ºC for 60 and 120 min,
respectively, using sulphuric acid. Furthermore the nanocellulose was characterized using particle
size analyzer, Fourier transform infrared spectroscopy and X-ray diffractions. The particle size analysis
showed that the diameter of the nanocellulose was affected by hydrolysis time. In addition, the X-ray
diffractions results showed that the crystallinity index of the nanocellulose was 71.99% and 71.61%
for the acid hydrolysis time of 60 min and 120 min, respectively. This study also demonstrated that the
aquatic wetland plant, E. dulcis has a good potential for nanocellulose production in Indonesia.
Investigation of Alcaftadine using a Double Oxidation
Process by Eliminating Column Chromatography
Authors: Lahoti Anand M. , Ambhaikar Narendra B. , Rajagopal Reddy D.M. , Roy Arnab , Krishna Reddy Kallam V.S.R. , Rao S. Mahender
Published: May 2022

Alcaftadine is an active pharmaceutical ingredient (API) used as an ophthalmic solution for the
prevention of itching associated with allergic conjunctivitis. The originally reported synthesis uses a
time-consuming column chromatography technique for the isolation of hydroxymethylated product
alcohol (10). A simple yet effective double oxidation strategy is developed using oxidation grade
manganese dioxide to avoid tedious chromatographic purification. Firstly, a partial oxidation of
hydroxymethylated crude mass (mixture of compounds 9, 10 and 16) was carried out using a limited
amount of MnO2 to get rid of critical diol impurity (16) and to allow crystallization of alcohol (10)
crude, followed by its second oxidation using additional MnO2 to provide alcaftadine via a scale-up
friendly process. This synthetic approach has been proven to be cost effective and commercially viable.
Various impurities formed during the process were also identified and eliminated to obtain ICH guideline
purity of alcaftadine API. The process was validated in plant scale and US DMF was filed to manufacture
alcaftadine API.
Synergetic and Cooperative Effects in Multimetallic Macrocyclic
Complexes for Biological, Catalytic and Magnetic Activity
Authors: Chaudhary Ashu , Mamta
Published: May 2022

The advancement of direct synthetic approaches toward the controllable synthesis of multimetallic
complexes turns into an earlier and significant undertaking before the inside and out investigations of
novel properties and functions of multimetallic complexes. As an elective methodologies for the
synthesis of multimetallic complexes have incorporated the utilization of large macrocycles with more
than one binding site and furthermore the connecting of macrocycles through interfacing units. This
review highlights the arising patterns in the synthesis and uses of multimetallic macrocyclic complexes,
including bi- and tri-metallic gatherings just as bigger obvious metal clusters and polymeric species.
Synthesis, Characterization and Structural Analysis of Cobaloximes Complexes
Authors: Selvi M. Amutha , Sherina Mary S. Preethi , Chandradevi R.
Published: May 2022

A series of bioactive cobalt(III) complexes were synthesized with bidentate ligand have been investigated
as vitamin B12 models. The experiment was two pot snythesis, in the first part was green microcrystalline
dihalo(dimethylglyoximato)cobalt(III) and second part was brown microcrystalline halo(pyridine based
ligand) cobaloximes. Final part of synthesized complexes was characterized by IR, electronic and
NMR spectral studies. Infrared spectra of metal complexes indicated the formation of Co-N axial
bond and Co-N equatorial bond. Thermal analysis revealed that the Co(III) complexes were stable up
to 350 ºC. The experimental results of antimicrobial were showed good zone of inhibition towards
selected microbes.
Assessment of Groundwater Quality for Drinking and Irrigation
Use in Gurugram Block of Gurugram District, Haryana, India
Authors: Laxmi Vijay , Hussain Jakir , Husain Ikbal , Gambhir Geetu
Published: May 2022

Groundwater is a vital and reliable source of water in all climates worldwide. In this work, a total of
26 groundwater samples were collected from the Gurugram Block of Gurugram District (a cosmopolitan
city situtated proximately to capital of India) analyzed for electrical conductivity, pH, hardness, dissolved
solids (TDS), Na+, K+, Ca2+, Mg2+, Cl- and alkalinity as HCO3
−, CO3
2−. Based on the analytical results,
the sodium adsorption ratio, sodium percentage, residual sodium carbonate, chloro-alkaline index,
base exchange index, meteoric genesis index, permeability index), magnesium hazard and Kelly index
were calculated. The most abundant cations were Na+ and Ca2+, which accounted for 43% and 36% of
total cations, respectively. Based on median value, the cations are in the following order: Na+ > Ca2+ >
Mg2+ > K+. There are no dangers in any of the 22 villages (85%). They have fluoride levels which are
less than the maximum desirable limit of 1.0 mg/L established by IS: 10500, 2012. There were 15
villages (58%) with nitrate concentrations less than the limit (45 mg/L) and 11 villages (42%) with
nitrate concentrations greater than the limit. The conductivity of groundwater samples was dominated
by the ions EC-TDS (r = 1.0), EC-Na (r = 0.93) and EC-HCO3 (r = 0.84). The natural origin of the ions
was revealed by the Na-Cl correlation coefficient (r = 0.82). TDS and Na correlated positively (r =
0.93). Wilcox classified that 4% of the ground water samples as excellent to good, 19% as good to
permissible, more than 19% as doubtful to unsuitable and 58% as unsuitable for irrigation. According
to the US salinity diagram,% of the samples fall into the C3–S1 water class, indicating water with a
high salinity hazard and a low sodium hazard.
ANALISIS PENEMUAN BARANG BUKTI DIGITAL MELALUI REKAMAN SUARA MENGGUNAKAN PRAAT DENGAN METODE AUDIO FORENSIK
Authors: Hafiz Pratama S Nawawi
Published: May 2022

Perkembangan zaman saat ini membawa pengaruh besar kedalam dunia digital, informasi bisa diterima sangat cepat, namun dalam menerima informasi yang didapat seringkali masyarakat salah menggunakan nya, salah satu diantaranya informasi penyebaran  hoax mengenai vaksin sinovac yang masuk ke Indonesia, banyak opini yang masyarakat terima tentang hal negatif setelah melakukan vaksin tersebut. Salah satunya berupa rekaman suara yang beredar tentang informasi bohong vaksin tersebut. Tujuan dari penelitian ini adalah membuktikan rekaman suara yang diterima identik atau tidak berdasarkan jenis kelamin. Oleh karena itu perlu penanganan forensik untuk mengidentifikasi bukti digital dengan menggunakan metode audio forensik. Sedangkan metodologi yang digunakan adalah SOP 12 DFAT (Digital Forensic Analyst Team) dengan melakukan proses akuisisi, enhancement, decoding dan voice recognition. Tools yang digunakan dalam penelitian ini yaitu  Adobe Audition CS6, Praat , dan Gnumeric. Analisis dilakukan dengan mencari nilai statistik pitch, formant dan, spectrogram dimana dari hasil ketiga komponen suara tersebut. Hasil yang didapat dari tujuh sampel suara yang identik dengan barang bukti yaitu sampel suara ke-7 dan jenis kelamin dari masing masing rekaman suara yang dimiliki yaitu tujuh orang laki-laki dan satu orang perempuan. Bukti yang ditemukan merupakan bukti yang sah berdasarkan  UU Nomor 11 Tahun 2008 Tentang Informasi dan Transaksi Elektronik dan UU ITE No 19 Tahun 2016 Pasal 28 Ayat 1 mengenai berita penyebaran hoaks di media elektronik.
Définition et aspects linguistiques des petites annonces de cœur
Authors: Roa Bernal Jimmy Spencer
Published: May 2022

Cet article essaie, sans prétention, de travailler sur un micro-discours qui s’est développé au cours de ces dernières années: les petites annonces de cœur. Il est bien connu qu’une des manières la plus facile et rapide de rencontrer quelqu’un est à travers de ce moyen: une personne esquisse un portrait positif de soi et en même temps attire l’attention de la personne désirée en employant un minimum de mots. Or, quelles sont les caractéristiques inhérentes à ce type de discours? Tout d’abord, nous définirons plus précisément ce type de discours ainsi que sa structure, pour enfin s’intéresser à la séquence prototypique des petites annonces en introduisant des exemples illustratifs
El discurso en los procesos evaluativos y su relación con el desarrollo de los niveles de pensamiento en la asignatura de Matemáticas grado 5.
Authors: Echevarría Bermúdez Diana C. , Fernández Luz Esther
Published: May 2022

El propósito del presente estudio es analizar las características del discurso en la interacción (maestro – texto – alumno) en los procesos evaluativos y su relación con el desarrollo de los niveles de pensamiento en la asignatura de Matemáticas grado 5. El estudio fue de carácter cualitativo de corte etnográfico, mirado desde las perspectivas de la lingüística sistémico-funcional de Halliday (1978), concretamente en las metafunciones interpersonal y textual, de los niveles de pensamiento de Villarini (1997) y la evaluación (IRE) de Cazden (1991). Observamos, transcribimos y analizamos secuencias didácticas de clases de matemáticas encontrándose que el profesor, el texto y la evaluación promovieron un pensamiento automático.
Percepción y actitudes hacia la inclusión educativa de los docentes de Soledad, Atlántico (Colombia), 2008.
Authors: Díaz Haydar Orietta , Media Fabio Franco
Published: May 2022

Fundamentados en políticas mundiales de inclusión social y características sociodemográficas de vulnerabilidad del municipio de Soledad (Atlántico) se propuso, como objetivo de esta investigación, caracterizar e interpretar las actitudes de los docentes de Soledad hacia la inclusión educativa, desde su propia perspectiva, través de la aplicación de escala de actitudes, análisis de su discurso y observación persistente. Se aplicó la metodología hermenéutica, utilizando, triangulación múltiple, escala de actitudes (EAPROF) como pretexto de las entrevistas y entrevistas focalizadas con actores claves, contrastándolo todo con observaciones de campo. Con la escala de actitudes se identificó ambivalencia en las actitudes de los docentes hacia la inclusión educativa y del análisis del discurso emergieron categorías que muestran la importancia y urgencia de realizar acciones tendientes a propiciar actitudes favorables en los docentes, para asegurar así el éxito de la inclusión en el municipio de Soledad.
La docencia en entornos virtuales interculturales
Authors: Ricardo Barreto Carmen Tulia , Mizuno Haydar Jorge Miguel
Published: May 2022

Este artículo presenta algunos de los resultados del diseño de la asignatura virtual E-learning, realizada con un enfoque intercultural, utilizando la teoría constructivista y sociocognitiva y algunos elementos de la teoría artística y sociocomunicativa. El objetivo es analizar si el diseño guarda coherencia con el modelo didáctico propuesto por el profesor. En esta asignatura, el docente recrea situaciones didácticas en el ambiente virtual del curso, convirtiéndose en un guía y orientador del proceso de enseñanzaaprendizaje, siendo el estudiante el centro de este proceso. Como metodología se tuvieron en cuenta los aspectos esenciales de la investigación etnográfica utilizando como estrategias cualitativas el análisis de contenido y entrevistas a estudiantes, complementadas con un pretest y un postest que estima el dominio de las competencias de los estudiantes en su proceso de formación. Los resultados del estudio muestran que el componente intercultural se encuentra estructurado dentro del currículo y ayuda al desarrollo del pensamiento crítico y de las competencias de los estudiantes, y a una mejor afectividad en el desarrollo del curso. La investigación señala que el componente intercultural es un elemento clave dentro del currículo de cualquier asignatura especialmente las virtuales, donde participan personas de diferentes culturas y contextos.
Cavilaciones sobre el interés simple.
Authors: Cabeza de Vergara Leonor
Published: May 2022

Como producto de las reflexiones sobre la conceptualización del interés simple surgieron dos preguntas a nivel de clase: ¿Por qué, bajo la modalidad del interés simple, el presente de cada una de las cuotas constantes vencidas no es igual al presente de la anualidad vencida?, y ¿Qué porción de una cuota vencida bajo el interés simple se asigna a interés y a capital? Para trabajar estos interrogantes se partió de un caso práctico y con el soporte conceptual de interés simple, series, serie armónica, propiedades de las desigualdades de las series y el concepto de integral se comprobó y demostró la diferencia entre el presente de una anualidad vencida y la suma del presente de cada cuota vencida. Seguidamente se determinó una ecuación que permitió discriminar, en cada cuota vencida, bajo la modalidad de interés simple, que porción se asigna al pago de intereses y a capital respectivamente.
Los documentos históricos: su utilidad como medio de evaluación docente
Authors: Rodríguez Domínguez Luisa de los Ángeles
Published: May 2022

El artículo destaca la creación de una metodología necesaria para el uso de las fuentes documentales originales para el desarrollo del trabajo curricular y extracurricular de los estudiantes, utilizada, tanto por los profesores y estudiantes como parte de la evaluación integral dentro de las asignaturas de formación humanística. Ellas contribuyen a formar en los estudiantes la continuidad del debate científico económico a lo largo de los años de la carrera, relacionadas con las clases de varias asignaturas que dependen de otras áreas del conocimiento, comprenden sus posibilidades reales de utilización y la necesidad de su dominio, la solidez de los conocimientos, y habilidades, logrando el desarrollo de capacidades, que les llevan a emitir un juicio de valor.