bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between gross motor function and quality of life in a group of Brazilian adults with cerebral palsy: an exploratory study
Authors: Ribeiro Marina Fernandes , Mendonça Ana Paula de , Morais Rosane Luzia de Souza
Published: January 2025

ABSTRACT International studies indicate that gross motor function can influence the health-related quality of life (HRQoL) of adults with Cerebral Palsy (CP). However, HRQoL is a complex construct that may also be influenced by cultural factors. Objective: To verify the association between Gross Motor Function (GMF) and HRQoL in a group of Brazilian adults with CP. Methods: This quantitative, cross-sectional and exploratory study included 30 individuals with CP, aged between 18 and 54 years old, living in a small/medium-sized municipality. Gross motor function was assessed using the the Gross Motor Function Classification System (GMFCS), while HRQoL was measured using the Short-Form Health Survey (SF-36), divided into physical and mental health summaries. Results: Better GMF explained 37% (adjusted R² = 0.373) of the variability in HRQoL related to functional capacity, and 22% (adjusted R² = 0.221) of the physical aspects summary. Conversely, a more compromised GMF explained 15% (adjusted R² = 0.146) of the variability in HRQoL related to emotional aspects. Conclusions: Better GMF partially explains higher HRQoL related to greater physical functioning or summary of physical aspects. On the other hand, greater impairment in GMF partially explains higher HRQoL related to emotional aspects in adults with CP residing in a Brazilian municipality. These results align with findings from international studies.
Associação entre função motora grossa e qualidade de vida de um grupo de adultos brasileiros com paralisa cerebral: um estudo exploratório
Authors: Ribeiro Marina Fernandes , Mendonça Ana Paula de , Morais Rosane Luzia de Souza
Published: January 2025

RESUMO Estudos internacionais indicam que a função motora grossa pode influenciar na qualidade de vida relacionada à saúde (QVRS) de adultos com paralisia cerebral (PC); entretanto, a QVRS é um constructo complexo e pode ser influenciada por fatores culturais. O objetivo do trabalho foi verificar a associação entre a função motora grossa (FMG) e a QVRS de um grupo de adultos brasileiros com PC. Trata-se de estudo quantitativo, transversal e exploratório realizado com 30 indivíduos com PC, com idades entre 18 e 54 anos e residentes em um município de pequeno/médio porte. Para a função motora grossa foi utilizado o Sistema de Classificação da Função Motora Grossa (GMFCS). Para a QVRS foi utilizado o Short-Form Health Survey (SF-36), dividido entre sumário de aspectos físicos e sumário de aspectos mentais. Os resultados obtidos indicam que uma melhor FMG explica 37% (R² ajustado=0,373) da QVRS relacionada à capacidade funcional e 22% (R² ajustado =0,221) da relacionada ao sumário de aspectos físicos. Por outro lado, uma FMG mais comprometida explica 15% (R² ajustado=0,146) da QVRS relacionada aos aspectos emocionais. Assim, tem-se que uma melhor FMG explica parte da QVRS relacionada a maior capacidade funcional ou ao sumário de aspectos fisicos; em contrapartida, um maior comprometimento da FMG explica, em parte, uma maior QVRS relacionada aos aspectos emocionais de adultos com PC residentes de um município brasileiro. Esses resultados corroboram achados da literatura internacional.
Can electronic screens influence head and neck posture in adolescents? A systematic review
Authors: Turci Aline Mendonça , Nogueira Camila Gorla , Bersanetti Michelli Belotti
Published: January 2025

ABSTRACT This systematic review aims to identify whether electronic screens can influence head and neck posture in adolescents. This study was registered in PROSPERO and the databases used were EMBASE, LILACS, SciELO, PEDro, PubMed, and Scopus, with no language or publication date limitations. The keywords used were posture, neck, and adolescents. A total of 1,997 articles with duplicates were found, 1,858 articles were excluded after title reading and 65 after abstract reading. During the analysis of the full texts, 22 were excluded because they addressed individuals with an average age of less than 15 or more than 19 years, 10 did not refer to technology use, and three only evaluated symptomatic individuals, therefore, only four articles were reviewed. The methodological quality of the studies was defined according to the Newcastle Ottawa Quality Assessment Scale, with three being classified as good methodological quality and analyzing posture when using a computer, and one with poor quality that analyzed posture when using a smartphone. Therefore, regarding smartphone use, considerations are limited. Overall, computer use is not responsible for postural changes in the head and neck of adolescents; however, more studies are needed to confirm this conclusion.
Comparison of low back pain prevalence in adults between pre-pandemic and pandemic periods and related biopsychosocial aspects
Authors: Mayer Kerolyne Soares , Pilling Betiane Moreira , Candotti Cláudia Tarragô
Published: January 2025

ABSTRACT The global health crisis resulting from the outbreak of the coronavirus (SARS-CoV-2) has led to social distancing, the repercussions of which on physical and mental health are still being assessed. This study aims to compare reported lower back pain in adults during the pre-pandemic and pandemic periods regarding intensity and frequency, as well as the risk of poor prognosis, disability, exposure to risk factors, beliefs, fears, and sitting posture in front of the computer. The sample of this retrospective study with a comparative ex post facto design consisted of 80 individuals with complaints of low back pain, divided by sex, age, height, and body mass-matched groups: 40 individuals in the pre-pandemic group (PPG) and 40 individuals in the pandemic group (PG), who were involved in university outreach projects. Data were collected using BackPEI-A, SBST, ODI, and FABQ questionnaires from 2016 to 2021. Mann–Whitney u-test and Student’s t -test were used for group comparisons (α <0.05). Comparison between PPG and PG showed no statistically significant differences regarding impairment, frequency, intensity of pain, sitting posture in front of the computer, exposure to risk factors, risk of poor prognosis, beliefs and fears, and disability.
Comparação entre os períodos de pré-pandemia e pandemia da prevalência de dor lombar em adultos e dos aspectos biopsicossociais relacionados
Authors: Mayer Kerolyne Soares , Pilling Betiane Moreira , Candotti Cláudia Tarragô
Published: January 2025

RESUMO A crise sanitária mundial, decorrente do surto de coronavírus (SARS-CoV-2), ocasionou o distanciamento social, cujas repercussões na saúde física e mental ainda estão sendo aferidas. O objetivo deste estudo foi comparar a dor lombar relatada por adultos, nos períodos de pré-pandemia e pandemia, quanto à intensidade e frequência, bem como o risco de mau prognóstico, a incapacidade, a exposição aos fatores de risco, às crenças, aos medos e à postura sentada em frente ao computador. A amostra deste estudo retrospectivo, com delineamento ex post facto comparativo, foi composta por 80 indivíduos com queixa de lombalgia, divididos em dois grupos pareados por sexo, idade, estatura e massa corporal: 40 indivíduos no grupo pré-pandemia (GPP) e 40 indivíduos no grupo pandemia (GP), que participavam de projetos de extensão universitária. Os dados foram coletados entre os anos de 2016 e 2021 e eram oriundos dos questionários BackPEI-A, STarT, ODI e FABQ. Os testes Mann-Whitney e teste t foram utilizados para a comparação entre os grupos (α<0,05). A comparação entre o GPP e GP não mostrou diferença estatisticamente significativa quanto ao impedimento, frequência, intensidade da dor, postura sentada em frente ao computador e exposição aos fatores de risco; risco de mau prognóstico; crenças e medos; e incapacidade.
La traducción y la empatía en la comprensión de las fuerzas militares colombianas: Hacia una expansión de los horizontes antropológicos
Authors: Angel Ana María Forero
Published: January 2025

Resumen Atendiendo a la invitación que este dossier extiende: ‘reflexionar sobre los desafíos teóricos, metodológicos, morales y éticos cuando se trabaja con las alteridades incómodas’, me ocuparé de la siguiente pregunta: ¿Qué consecuencias tiene para la antropología social asumir las demandas de escucha de grupos incómodos? Para responder a esta pregunta me valdré del material etnográfico construido entre los años 2005 y 2008 con oficiales historiadores del Ejército Nacional de Colombia. Además, sostendré que la empatía y el respeto a las demandas de escucha son condiciones imprescindibles para la etnografía; esto se debe, a que al detenerse en la comprensión del ‘otro incómodo’ se amplían los horizontes disciplinares y se multiplica el conocimiento sobre las diferentes formas de estar en el mundo.
Grappling With Complexity in Research with the Military Police The Far-Right and Anthropology’s Civilizing Mission
Authors: Salem Tomás
Published: January 2025

Abstract: This text examines the challenges of carrying out fieldwork with the Military Police, an institution responsible for systematically targeting Rio de Janeiro’s favela populations with extreme levels of racialized state violence. It discusses how anthropologists can describe police officers in ways that avoid the pitfalls of binary thinking: of reproducing a cosmology of war that assumes a strict division between good and evil and instead produce accounts that hold space for complexity and change, without assuming a moral relativist position.
A Photographic Essay on Solid Waste Recycling: Street Ethnography and Innovative Experiences in the Netherlands
Authors: Eckert Cornelia , Rial Carmen Silvia de Moraes
Published: January 2025

Abstract This photographic essay explores solid waste management and recycling practices among residents of Zaandam and other towns in the Netherlands. The study was based on ethnographic research conducted in September 2019 and December 2021 that included street ethnography, landscape observation, and recorded interviews. The photo essay presents a narrative of the researcher’s observations and experiences, highlighting the challenges and successes of waste management and recycling practices in the Netherlands.
Between revolution and human rights: the testimonies of Brazilian exiles at the Russell Tribunal II
Authors: Magaldi Felipe , Sarti Cynthia
Published: January 2025

Abstract: In this article, we study the testimonies given at the Russell Tribunal II, held in Rome in 1974 with the objective of denouncing Latin American dictatorships. The event was attended by exiles who had been arrested and tortured after joining clandestine organizations opposing Brazil’s military dictatorship. The article analyses their testimonies based on documents published by the Amnesty Commission’s Marks of Memory Project and others consulted at the Basso Foundation (Italy) and the National Archives (Brazil), as well as other dispersed records. The public expression of suffering is highlighted as a main vector of transformation in the repertoires of political action at the time, situated at the intersection between the ideals of the revolutionary left and those of human rights. This process exposed the limits to the idea of a purely individual aspect of suffering and the presumption of its incommunicable or unspeakable nature - both shown to be ways of silencing its political dimension.
Auriculoacupuntura com laser e com agulhas no tratamento da ansiedade de universitários: ensaio clínico randomizado
Authors: Lemos Ana Paula da Silva , Lourenço Bárbara Guimarães , Chaves Érika de Cássia Lopes , Toledo Luana Vieira , Chianca Tânia Couto Machado , Moura Caroline de Castro
Published: January 2025

RESUMO Objetivo: Comparar a efetividade da auriculoacupuntura com laser e agulhas no tratamento da ansiedade em universitários no contexto pós pandêmico da Covid-19, bem como avaliar os possíveis sintomas ou reações adversas desencadeados pelas intervenções. Método: Ensaio clínico randomizado realizado com 126 universitários, alocados nos grupos “Agulha” (controle) e “Laser” (experimental). Foram realizadas cinco sessões de auriculoacupuntura. As avaliações foram realizadas antes, após o término do tratamento e sete dias após (follow up), por meio do Inventário de Ansiedade Estado e da mensuração das frequências cardíaca e respiratória. Empregou-se o Generalized Estimating Equations. Resultados: Houve redução nos níveis de ansiedade em ambos os grupos, entre as avaliações inicial e final, e inicial e follow up. Não houve diferença entre os grupos nas avalições final e follow up. A frequência cardíaca reduziu no grupo Agulha entre as avaliações final e follow up, e inicial e follow up; o grupo Laser permaneceu constante ao longo do tempo e os grupos não diferiram entre si entre o final e follow up. Não houve alteração ao longo do tempo na frequência respiratória em ambos os grupos e eles não diferiram entre si nas avaliações final e follow up. Houve maior ocorrência de reações adversas no grupo que recebeu a intervenção com agulhas, apesar da intensidade leve. Conclusão: Ambas as intervenções foram efetivas para redução do nível de ansiedade em universitários. Registro Brasileiro de Ensaios Clínicos RBR-8cxnvr2.
Governance and Value Appropriation in the Cocoa Bioeconomy at Amazonas
Authors: Trindade Lucas Xavier , Saes Maria Sylvia Macchione , Fernandes José Augusto Lacerda , Marcovitch Jacques
Published: January 2025

ABSTRACT Objective: this article identifies the mechanisms that guide governance and determine the possibilities of appropriation of value (income) by extractive producers who participate in different value chains of the cocoa bioeconomy in Amazonas. Theoretical approach: transaction cost economics, with an emphasis on the relationships between the specific conditions of assets and bargaining power over the appropriation of value, represents the basis for the two theoretical propositions formulated. Methods: a qualitative approach to multiple case studies was used in two regions (Madeira and Juruá rivers), which are representative of the value chains of the cocoa bioeconomy in Amazonas. Secondary (documents) and primary (interviews and focus group) data were analyzed using thematic analysis. Results: in the commodity and specialty cocoa chains, differentiated relational governance mechanisms have been established, which configure the distribution of bargaining power between intermediaries and producers and consequently the ability of these agents to appropriate value. Conclusion: swaying bargaining power in favor of producers depends on the presence of specific assets positioned to their benefit. The higher the level of specific assets involved in the transaction in favor of extractivists, as occurs in the specialty cocoa chain, the greater their bargaining power tends to be and, consequently, their opportunity to appropriate value. Encouraging the creation of value chains based on specific assets that increase producers’ ability to appropriate income is imperative to achieve an inclusive bioeconomy in the Amazon.
Physical development and sociocultural context influences on children’s physical activity
Authors: Ré Alessandro Hervaldo Nicolai , Cattuzzo Maria Teresa , Stodden David , Santos Guilherme dos , Tertuliano Albert Lucas Olinto , Monteiro Carlos Bandeira de Mello , Coledam Diogo Henrique Constantino , Okely Anthony David
Published: January 2025

Abstract Objective: To examine the predictive strength of cardiorespiratory fitness (CRF), motor competence (MC), maternal educational status, and parental perception of their children’s favorite leisure activities for meeting physical activity (PA) guidelines of each gender among children aged 3–6 years. Methods: This is a cross-sectional study with 367 preschoolers (53% girls), assessing CRF (PREFIT 20m shuttle run), MC (battery of motor skills), PA (accelerometry), maternal education and parental perception of children’s preferred leisure (questionnaires). Factorial analysis of covariance, multiple logistic regression, and chi-square tests were conducted. Results: In both genders, CRF was associated with meeting PA guidelines (girls: odds ratio [OR] 1.10; 95% confidence interval [CI] 1.03–1.18; boys: OR 1.12; 95%CI 1.05–1.19), independently of maternal education or parental perception of children’s leisure activities. For girls, active leisure with balls (OR 28.91; 95%CI 6.88–121.50) and without balls (OR 4.32; 95%CI 1.95–9.57) enhanced the odds of compliance with PA guidelines, without effect of maternal education. For boys, maternal education was inversely associated with meeting the PA guidelines. Boys of lower-educated mothers were more likely to have activities with balls as favorite leisure, which was a stronger predictor and enhanced the odds of meeting the guidelines (OR 4.09; 95%CI 1.71–9.79) regardless of maternal education. Boys had a higher prevalence of active leisure with balls than girls (42.8 vs. 7.7%). Conclusions: Regardless of CRF or MC, family and sociocultural circumstances influenced PA according to gender. Health policies should encourage equal gender participation in culturally significant sports or activities of a particular region/country, specifically within the family context.
Structure, floristic and diversity from Laguna de San Diego (Samaná, Colombia)
Authors: Sierra-Giraldo Julio Andrés , Velásquez-Franco Susana , Power Mitchell James , Orozco-Agudelo Jairo Andrés , Triana-Moreno Luz Amparo
Published: January 2025

Abstract The Magdalena Valley along the eastern slopes of the Central Andes in Colombia is characterized by both high biodiversity and endemism and human infrastructure development. In this study, we present the first botanical record from Distrito de Manejo Integrado Laguna de San Diego flora’s, part of South America’s northernmost active volcanic field. Here, we analyzed the diversity, structure, and composition in four different cover types (Dense forest: Bd, Mosaic of pastures with natural spaces: Mpen, Pastures: P, and Secondary vegetation: Vs). A total of 100 species and 42 botanical families were recorded. In Bd, the species with the highest IVI was Pourouma bicolor (20.9), while in the Mpen, was Triplaris dugandii (53.7); Psidium guajava (75.6) in P, and Guatteria punctata (21.2) in Vs. Bd exhibited the highest values of diversity across all measures (0D, 1D, and 2D). We strongly advocate for increased efforts to enhance the protection status and safeguard local species to protect biodiversity. This research adds to baseline botanical knowledge and should be used to minimize impacts of ecotourism, and the potential for future mining exploitation in biodiverse landscapes.
Phosphate binder in dialysis: a cross-sectional study of patients' adherence and pill burden
Authors: Ferezin Brunelle Bruna Scavello Coelho , Araújo Luiza Karla Ramos Pereira de , Lima Carolina Marquez , Abensur Hugo , Pereira Benedito Jorge , Dalboni Maria Aparecida , Moyses Rosa Maria Affonso , Elias Rosilene Motta
Published: January 2025

Abstract Introduction: Phosphate (P) binders are among the most common medications prescribed to control P levels in patients with chronic kidney disease on dialysis. There is still a paucity of data on adherence to P binders with no comparison between dialysis modalities. Methods: We accessed factors associated with P binder adherence among patients on dialysis in an academic hospital. Adherence was calculated as the ratio between the number of pills taken per day as reported and the prescribed number of pills. Patients were considered non-adherent if adherence was at least 20% less or 30% more than prescribed. Results: Patients (N = 137) were young, mostly women, and on dialysis for a median time of 53 months. Sevelamer and calcium carbonate were prescribed as P binders to 70.8% and 10.2% of patients, respectively, with no difference across dialysis modalities (p = 0.839). P correlated with the number of pills prescribed (r = 0.368, p = 0.001) and the number of pills taken per day (r = 0.275, p = 0.001). Hyperphosphatemia was found in 52 patients (36.4%). Adherence to Ca carbonate and sevelamer was 100% and 68.4%, respectively. Non-adherent patients were women, younger, with higher serum albumin and urea, and lower serum calcium. Logistic regression showed that female sex (HR 3.30, 95% CI: 1.39–7.84, p = 0.007) and hemodialysis vs. peritoneal dialysis (HR 4.55, 95%, CI: 1.26–16.39, p = 0.021) remained independently associated with a non-adherence behavior. Conclusions: The current study suggests that strategies to increase adherence should be implemented. Whether phosphate binder adherence is associated with better outcomes deserves further investigation.
Montreal Cognitive Assessment Hearing Impairment (MoCA-H): cross-cultural adaptation to Brazilian Portuguese
Authors: Machado Rochele Martins , Pagliarin Karina Carlesso , Patatt Fernanda Soares Aurélio
Published: January 2025

ABSTRACT Purpose This study aimed to adapt the Montreal Cognitive Assessment Hearing Impaired (MoCA-H) into Brazilian Portuguese (BP). Methods This was a descriptive, cross-sectional, quantitative, and qualitative study involving participants selected by convenience. The instrument was adapted from its original version, in a six-stage process consisting of the following: Stage 1 - Translation and back translation of the MoCA-H; Stage 2 - Stimulus analysis and selection; Stage 3 - Semantic analysis of stimuli; Stage 4 - Analysis by non-expert judges, part 1; Stage 5 - Analysis by non-expert judges, part 2; Stage 6 - Pilot study. The following statistical methods were used in this study: parametric T-test, Gwet’s first-order Agreement Coefficient (AC1), and the Content Validity Ratio (CVR). Results Cultural and linguistic adaptations were made to the instrument as well as changes to administration procedures to improve respondent comprehension. Participants with and without hearing loss had some comprehension difficulties in the visualspatial/executive domain task. This was observed not only in Stage 6 but also from the beginning of the adaptation process. Conclusion The adaptation process yielded an instrument with satisfactory content validity.
The perception of speech therapists regarding listening comprehension and the role of expressiveness
Authors: Ucedo Daniel De Martino , Santos Karoline Pimentel dos , Ghirardi Ana Carolina de Assis Moura , Santana Ana Paula de Oliveira
Published: January 2025

ABSTRACT Purpose to analyze speech therapists’ perception of the oral comprehension process and the role of expressiveness during assessment in the speech therapy clinic. Methods cross-sectional, analytical and qualitative study, carried out through interviews with six speech therapists working in the language area, in the state of Santa Catarina. Participants were recruited using the snowball method, forming a non-probabilistic sample. After transcribing the data, a content analysis of the participants’ statements was carried out. Results it was verified that the oral comprehension assessment was highlighted, by the participants, as a topic which was not discussed very much in the academic training which was insufficient to prepare them for the assessment of this skill. The concept of oral comprehension was mainly related to “hearing”, “understanding” and receptivity, while expressiveness was highlighted through mention of gestures and facial expressions. In clinical practice, informal assessment proved to be the mostly used method in the assessment of oral comprehensive language, to the detriment of the exclusive use of protocols, and expressiveness was unanimously highlighted by participants as a relevant criterion in the comprehension assessment process. Conclusion the analysis pointed out that comprehension and its relationship with expressiveness is a challenge in clinical practice. If, on the one hand, this is a less approached topic in academic training, on the other, there are few studies that propose to discuss the topic, which is reflected in the conceptual gap and reverberates in clinical practice. Therefore, studies of oral comprehensive language are emerging in the field of speech therapy.
TRAJETÓRIA DE CRESCIMENTO E NEGÓCIOS DO SETOR INFORMAL NA NIGERIA: O CASO DO ESTADO DE ENUGU
Authors: Uzoechina Benedict Ikemefuna , Okeke Ambrose Chiedozie , Ekwoh Geraldine Amaka , Oladipo Abimbola O.
Published: January 2025

RESUMO O setor informal tornou-se base para a geração de emprego, mas sua capacidade de crescimento e produção de bens e serviços ainda deixa dúvidas. Este estudo investigou a trajetória de crescimento das empresas do setor informal e os fatores que sustentam essa trajetória de desenvolvimento no Estado de Enugu, na Nigéria, a partir de uma amostra de 500 entrevistados oriundos de duas comunidades em cada uma das duas áreas de governo local das três zonas senatorias no estado. As técnicas de amostragem empregadas foram a amostragem intencional e a estratificada, sendo que a pesquisa adotou uma abordagem quantitativa e o método survey. Os resultados não confirmaram uma trajetória de crescimento vertical do setor informal no Estado de Enugu, mas confirmaram que fatores econômicos, demográficos e ambientais impulsionam o crescimento horizontal desse setor na região. Recomendamos, portanto, uma mudança de paradigma que possa conter a corrupção, permitir que os ganhos do crescimento sejam compartilhados de maneira a beneficiar todas as pessoas participantes do setor, criar acesso a financiamento e fornecer infraestruturas essenciais, facilitando a integração vertical do setor informal ao formal e melhorando a capacidade produtiva.
DIFERENTES MODELOS DE VENDAS, ORIENTAÇÃO FUNCIONAL E RELACIONAL AO CLIENTE, E DESEMPENHO DO VENDEDOR VAREJISTA
Authors: Adão Alyson Luis , Kato Heitor Takashi , Briggs Elten , Deretti Sandro
Published: January 2025

RESUMO Este estudo testa o efeito de diferentes modelos de vendas em um modelo conceitual, baseado na Teoria da Criatividade, que relaciona a orientação funcional e relacional do vendedor varejista ao seu desempenho. A criatividade do vendedor e os diferentes modelos de vendas do varejista são considerados variáveis mediadoras e moderadoras. A pesquisa coletou dados diádicos, de gerentes e vendedores, em 177 empresas varejistas no Brasil e utilizam PLS-SEM para testar as hipóteses do estudo. Entre os resultados do estudo, destaca-se que a moderação exercida pelos diferentes modelos de venda, disponibilizados pela empresa, contribui para que vendedores criativos, atuantes no varejo, se destaquem ainda mais ao poderem adaptar suas estratégias de vendas. Além disso, o estudo aponta que a orientação funcional do vendedor influencia negativamente a relação entre a orientação relacional do vendedor e a criatividade, sugerindo que tentar implementar simultaneamente ambas as orientações de cliente é subótimo em contextos de venda no varejo.
A tendência à neoinstitucionalização e o discurso religioso: elementos de análise para a reforma psiquiátrica
Authors: Corrêa Luisa Motta , Lima Rossano Cabral
Published: January 2025

Resumo A desinstitucionalização, apoiada na experiência da psiquiatria democrática italiana, se tornou o eixo principal das políticas da reforma psiquiátrica brasileira. Contudo, a tendência a isolar usuários de saúde mental ainda persiste, levando a internações recorrentes ou à neoinstitucionalização. Na ausência dos antigos manicômios, vêm se constituindo novos circuitos de confinamento da loucura, que têm as comunidades terapêuticas como exemplo paradigmático. Considerando que a instituição é o conjunto de dizeres, práticas e moralidades que levam à objetificação dos usuários, traduzindo a racionalidade dominante, é preciso revelar a ideologia destes novos redutos manicomiais para entender a função que cumprem na sociedade atual. O presente artigo busca, portanto, analisar, por meio de revisão bibliográfica narrativa, o que estas instituições representam, como operam e quais questões elas colocam para a rede de atenção psicossocial - em particular os Centros de Atenção Psicossocial (CAPS). Ao discutir o caso do Centro Vita e das comunidades terapêuticas, que expressam uma lógica semelhante, constatou-se que, se por um lado são locais destinados à morte dos improdutivos, por outro, encarnam moralidades e mentalidades atravessadas pelo discurso religioso, respondendo a necessidades subjetivas e existenciais que precisam ser tratadas com urgência, diante da crescente desfiliação social que assola os usuários de saúde mental e seus familiares.
Nonlinear analysis of reinforced concrete shells and the compressive membrane action on bridge deck slabs
Authors: Fernandes Beatriz da Costa , Silva Jordlly Reydson de Barros , Horowitz Bernardo
Published: January 2025

Abstract There are reinforced concrete problems where it is essential to analyze the reinforcement stresses at the crack, such as verifying the Fatigue Limit State in bridge deck slabs and crack opening in water tanks. In view of this, this work presents a numerical model called Cracked Shell Model (CSM), which enables the determination of stresses in the orthogonal reinforcement of concrete shell elements. The CSM uses the layered method, where the thickness of the shell element is discretized into concrete layers subjected to a plane stress state. The reinforcements are evaluated using the Cracked Membrane Model (CMM), which considers the compression softening of concrete and the tension stiffening effects via the Tension Chord Model (TCM). The validation of the CSM was carried out with experimental and numerical shell data available in the literature. It has been shown to be capable of predicting the complete behavior of reinforced concrete shell elements, with good accuracy and low computational cost. Additionally, a study was conducted on the Compressive Membrane Action (CMA) on bridge deck slabs, which tends to increase the load capacity of these slabs. With this study it can be observed that the CSM, despite the good performance presented in the validation phase, as it is based on Kirchhoff thin plate theory (usual practice in many projects) failed to capture this effect, underestimating the ultimate load by an average of 44% in relation to experimental tests. This article aims to contribute to developing numerical models of reinforced concrete shells, in problems where the maximum reinforcement stress is essential.
Use of guaco (Mikania glomerata) in primary health care in Rio Grande do Sul/Brazil
Authors: Santos Lidiane dos , Pilger Diogo , Zimmer Aline Rigon
Published: January 2025

Abstract Mikania glomerata (guaco) is included in Brazil’s National List of Essential Drugs (RENAME) with expectorant and bronchodilator indications. This research aims to describe the profile of patients and prescribers of guaco-based herbal medicines within the Unified Health System in the municipalities of Rio Grande do Sul (RS)/Brazil, quantify the consumption and cost of this product, and assess the prescriber’s experience with guaco and herbal medicine. A cross-sectional observational study was conducted based on questionnaires applied to prescribers and guaco usage data in primary care in RS municipalities (May 1, 2020 - April 30, 2021). 44 municipalities (40%) were identified dispensing guaco syrup in the sample. The results showed a prevalence of women users (57.4%) and patients between 19 and 59 years of age (58.2%). All participating prescribers were physicians, and 37% of the responses indicated daily doses of coumarin lower than recommended. The syrup consumption per 1,000 inhabitants ranged from 0.3 to 36.6 bottles, and the monthly cost per municipality varied from $0.50 to $247.78. Only five prescribers (21.7%) were familiar with the herbal medicines in RENAME, and only one had formal training for prescribing herbal medicines, highlighting the need for instruction and dissemination of programs for using herbal medicines.
Neuropharmacological profile of new thiazepinone and thiazolidinone compounds designed by virtual screening
Authors: Carrero-Sandoval Juan Sebastian , Cuervo-Prado Paola Andrea , Orozco-Lopez Fabian , Becerra-Rivas Christian Alonso , Arias-Quiroz Estefany , Guerrero-Pabón Mario Francisco
Published: January 2025

Abstract To evaluate the neuropharmacological profile of new spiro thiazepinone and thiazolidinone compounds in CD1 mice after a computer-aided virtual screening based on a GABA-A/BZD site. From a library of 240 pyrazolo[1,4]thiazepin-3-ones and 39 pyrimidinyl thiazolidin-4-ones, two molecular prototypes of each series were selected by virtual screening using the rank consensus molecular docking approach, based on the GABA-A/BZD site. These compounds, coded as cpTP-0, cpTP-1, TAP-2 and cpTAP-2, were synthesised by multicomponent reactions and evaluated by neuropharmacological screening in CD1 mice (100 mg/kg, p.o.). The study revealed that cpTAP-2 exhibited a significant reduction of immobility time during the forced swimming test (FST), while it did not show any major effects in the rota-rod, open field, plus maze, tail suspension, pentylenetetrazole seizures, and barbiturate sleeping time tests. In a dose-response evaluation, cpTAP-2 reduced immobility time during forced swimming test in CD1 male mice at doses of 100 and 300 mg/kg with biologically relevant effect sizes. These results suggest that cpTAP-2 could elicit antidepressant effects possibly related to GABA-A/benzodiazepine site, although other mechanisms could be implicated.
Chemical composition and larvicidal activity of the essential oil of Tagetes minuta Linnaeus from the southern Brazilian highlands
Authors: Sartor Elisiane de Bona , Schorr Renan Reisdörfer , Betim Fernando Cesar Martins , Anjos Cintia Aparecida dos , Oliveira Camila Freitas de , Dalarmi Luciane , Montrucchio Deise Prehs , Dias Josiane de Fátima Gaspari , Miguel Obdulio Gomes , Miguel Marilis Dallarmi
Published: January 2025

Abstract Tagetes minuta L. is a naturalized species that is not endemic to the high-altitude fields of Santa Catarina in southern Brazil. In this study, we investigated the composition of the essential oil (EO) from the flowers of the plant and its larvicidal activity against Aedes aegypti. The EO was obtained by hydrodistillation using a Clevenger apparatus. The chemical composition was determined using gas chromatography coupled with mass spectrometry (GC-MS). The EO extraction yield was 4.9%, and the major compounds (Z)-tagetone, (Z)-β-ocimene, and dihydrotagetone were identified. The 24 h larvicidal activity was verified against that of L3 larvae of the Rockefeller strain of Ae. Aegypti. The EO showed larvicidal activity against Ae. aegypti, with LC50 = 17.28 μg/mL-1. The results indicate that the bioinsecticidal potential of T. minuta EO is promising for the development of research in the field of natural products.
Fractionation and separation of bioactive peptides using natural polymeric membrane
Authors: Kalita Violina , Bhattacharyya Jyotirmoy , Bora Sidhartha Jyoti , Kalita Rupjyoti , Dutta Partha Pratim
Published: January 2025

Abstract The increasing interest in bioactive peptides (BPs) for their potential in disease control and health promotion has been accompanied by a lack of scalable processes for their purification, hindering their commercial production. Membrane filtration, especially using polymeric membranes (PMs), has emerged as a promising technique for BP separation due to its excellent separation performance, ease of fabrication, and flexibility. By utilizing natural sources, such as chitosan, cellulose, lignin, gelatin, alginate, keratin, and silk fibroin, in PM production, the environmental impact of membrane-based separation processes can be reduced while maintaining sustainable, eco-friendly approaches. Natural polymer membranes have exhibited excellent separation performance in terms of molecular weight cut-off and rejection of unwanted compounds, and their performance can be further improved by combining them with nanoparticles or other polymers. This review presents the recent updates on the use of PMs derived from natural sources for the separation of BPs, covering the production and functions of BPs, different membrane separation technologies, and challenges faced during downstream purification.
Proton pump inhibitor leaflets: Is there information on deprescribing?
Authors: Campos Marcus Vinícius Lopes , Chequer Farah Maria Drumond , Silva Luanna Gabriella Resende da , Baldoni André Oliveira
Published: January 2025

Abstract This study aims to analyze the existence of information about deprescription in the leaflets of proton pump inhibitor (PPI) medications. The leaflets available on the Brazilian Health Regulatory Agency (ANVISA) and Food and Drug Administration (FDA) websites for the following medications were analyzed: omeprazole, esomeprazole, lansoprazole, dexlansoprazole, pantoprazole, and rabeprazole. The variables collected in each leaflet were the existence: a) about deprescribing; b) of guidance on the deprescription process; c) maximum recommended time for use; and d) risk of prolonged use. This information was analyzed in accordance with the PPI deprescription guideline, from Canada. Regarding the medication leaflets, 83.33 % from ANVISA and 100 % from the FDA did not present explicit and systematic guidance on deprescribing. Regarding the maximum time of use, 100 % of the leaflets from both agencies contained this information. Regarding the risks of prolonged use of the medication, 33.33 % of the ANVISA leaflets and 33.3 % of the FDA leaflets did not report the increased risks described in the guideline. The results highlight a large gap in information about deprescribing in PPI leaflets; this highlighting is necessary to contribute to the promotion of the rational use of medicines.
Unlocking Dabrafenib’s Potential: A Quality by Design (QBD) Journey to Enhance Permeation and Oral Bioavailability through Nanosponge Formulation
Authors: Reddy Konda Sri Chaya , Bhikshapathi Darna , Kumar Jaini Pavan
Published: January 2025

Abstract This research aims to create dabrafenib (DBF)-loaded nanosponges (NSPs) using β-cyclodextrin (β-CD) and diphenyl carbonate (DPC) as linker to improve oral bioavailability. DBF-loaded β-CD NSPs were synthesized by finely adjusting the molar ratio of β-CD to DPC and optimizing the stirring rate and duration using design methodology. After being loaded with DBF, the produced β-CD NSPs were characterized in terms of particle size, zeta potential (Z.P), polydispersity index (PdI), and drug entrapment efficiency (E.E). Studies on compatibility were carried out with FTIR (Fourier Transform Infrared Spectroscopy) and DSC (Differential Scanning Calorimetry). Permeability, in vivo, and in vitro experiments were performed on the improved NSPs and the pure medication. After optimizing DBF-loaded β-CD NSPs, a formulation with a mean size of 158.0 ± 7.2 nm, PdI of 0.282 ± 0.0044, and E.E of 86.23 ± 2.45% was obtained, based on the assessments indicated earlier. Zeta sizer, SEM, spectrum analysis, in vitro release, and pharmacokinetic tests were among the other analyses that further validated the optimization. An area under the curve (AUC0-t) of 7.95-fold greater and a Cmax 7.356 times higher than those of the free drug was demonstrated by the optimized β-CD NSPs, which showed a notable boost. The use of DBF-loaded NSPs holds promise as an effective strategy for enhancing release and bioavailability in the treatment of melanoma.
A novel nano-emulsion cream of casein isolated from raw milk for thermal and acid burn wounds
Authors: Shrivastava Shivani , Das Saumya , Sharma Chanchal , Singh Archna , Das Sanjita , Das Manas Kumar , Tyagi Pankaj Kumar , Khurana Navneet
Published: January 2025

Abstract Traditionally, raw cow milk has been employed to treat acid and thermal burns due to its antibacterial, antibiotic, and antifungal properties. It also aids in preventing scarring and alleviating burn-related skin discomfort. This study focuses on evaluating a nanoemulsion cream made from casein extracted from raw cow milk for managing acid and thermal burns. Casein was isolated and used to create 2%, 5%, and 10% w/w nanoemulsion creams. Wistar albino rats were used to induce acid and thermal burns, and the healing progress was monitored by measuring wound contraction and epithelialization period. The results demonstrated significant wound healing effects of the casein creams (p<0.001) in acid burns, with the 10% w/w cream showing the highest epithelization rate in thermal burns. Raw milk also exhibited notable healing properties in acid burns. However, its effectiveness was relatively lower in thermal burns. This study suggests that raw milk and its casein-derived creams could be utilized as first-aid treatments for acid burns, though they may be less effective for thermal burns.
Composition of food supplements containing melatonin available in Portugal
Authors: Araújo Beatriz Vieira , Rato Fátima , Capela João Paulo
Published: January 2025

Abstract Melatonin straddles the boundary between food supplements and medicine. In Portugal, its classification is contingent upon a critical dosage threshold of 2 mg. This study aimed to detail the composition of melatonin-containing food supplements, available in Portugal based on their labels, and report the number of potential intoxications. Data was collected from 44 food supplements, and the difference in active ingredients was revealed towards the 16 approved medicines. Data on melatonin intoxication cases from 2018 to 2022 were obtained from the Portuguese Poisons Information Center (CIAV). Melatonin supplements, available in tablets, capsules, gummies, powders, or sprays, exhibited a recommended daily dose ranging from 1 to 1.95 mg. Only 20% contained melatonin alone, while the majority included plant extracts and vitamins. The absence of clinical studies supporting the efficacy of melatonin combined with plant extracts in these formulations raises concerns about their evidence-based effectiveness. Medicines contain 2 to 3 mg of melatonin per tablet, either immediate or modified release. Melatonin intoxication occurs mainly in children, with a higher prevalence between the first year of life and the age of four. Food supplements containing melatonin and plant extracts should be more carefully studied, including the potential adverse effects.
Physiologically-based pharmacokinetic modeling of enantioselective hydroxychloroquine kinetics and impact of genetic polymorphisms
Authors: Ribeiro Gabriella de Souza Gomes , Pippa Leandro Francisco , Moreira Fernanda de Lima , Moraes Natália Valadares de
Published: January 2025

Abstract Hydroxychloroquine (HCQ) is a chiral drug used to treat malaria and inflammatory diseases, available as a racemic mixture of R-and S-HCQ. This work aimed to build physiologically-based pharmacokinetic (PBPK) models to predict the pharmacokinetics (PK) of R-and S-HCQ and assess the impact of major genetic polymorphisms on PK. Whole-body PBPK models accounting for first-order absorption, Rodgers and Rowland distribution method, and enzyme kinetics data were built for R-and S-HCQ. The models were verified by comparing predicted PK parameters with observed ones, with a mean error within the acceptable range (0.5-2 fold). Simulations covered CYP2D6 normal metabolizer (NM), poor metabolizer (PM), and ultra-rapid metabolizer (UM) phenotypes, as well as CYP2C8 NM and PM phenotypes. The results revealed a 1.1-fold increase in area under the curve blood concentration versus time (AUC) for CYP2D6 PM individuals and a 0.9-fold reduction for UM individuals compared to NM individuals. In addition, simulations with CYP2D6 and CYP2C8 PM phenotype individuals combined with the CYP3A4 inhibitor clarithromycin showed increased AUC for R-and S-HCQ of 2.34 and 2.68, respectively. These PBPK models offer reliable predictions for R-and S-HCQ enantioselective kinetics and shed light on previously unexplored scenarios.
Mapeamento da população trans da Baixada Santista, 2023: estudo descritivo
Authors: Barroso Barbara Iansã de Lima , Bassichetto Katia Cristina , Vieira Denise Leite , Gois Ísis , Rodrigues Julliana Luiz , Santos Naila Janilde Seabra , Souza Paola Alves de , Tayra Angela , Kumow Aline , Moreira Karin Di Monteiro , Maidel Fe , Veras Maria Amélia de Sousa Mascena , Dièguez Carla Regina Mota Alonso , Kruger Alícia , Ribeiro Maria Clara Gianna Garcia , Souza Rosa de Alencar , Luppi Carla Gianna
Published: January 2025

RESUMO Objetivo Descrever as características socioeconômicas e demográficas da população trans da Baixada Santista. Métodos Trata-se de estudo descritivo, com pessoas trans adultas, selecionadas por amostra de conveniência em 2023. Foi aplicado questionário quantitativo e realizadas entrevistas em profundidade, analisadas por agrupamento temático. Resultados Foram recrutadas 237 pessoas. Dessas, 42,2% se identificaram como mulher trans/travesti e 36,3% como homem trans/transmasculino; 65,4% tinham até 29 anos de idade; 51,1% se autodeclararam de raça/cor da pele branca; 52,7% eram solteiras; 80,5% tinham, no mínimo, o ensino médio completo; 32,5% não tinham renda. A autopercepção da identidade trans ocorreu majoritariamente entre 10 e 19 anos (55,7%), com início da transição social entre 15 e 19 anos (41,8%). Foram realizadas 14 entrevistas em profundidade. Conclusão Os aspectos socioeconômicos – escolaridade, emprego e renda – estão na centralidade da identidade de gênero. Ações e políticas públicas precisam ser criadas e aprimoradas.
Numerical and experimental investigations on bio-inspired lattice forms as structural reinforcement
Authors: S Sindhu Nachiar , S Anandh , M Riyas Ahamed , M Kowsalya
Published: January 2025

Biomimicry in concrete holds the potential to revolutionize construction, making it more sustainable, innovative, and in harmony with the natural world. By mimicking natural structures and processes, bio-inspired designs can enhance concrete’s resilience, toughness, and self-healing qualities. The present study investigates lattice pattern inspired by a Venus’ flower basket (glass sponge) as reinforcement in compression members. The performance of bio-inspired lattice pattern (BLP) with two other conventional lattice patterns (CLP1 and CLP2) was studied by numerical simulations and experimental investigations. The preliminary investigation includes the fabrication of three-dimensional (3D) lattice cubes from which the compressive strength of BLP was found to be increased by 9.84% and 24.59% when compared with CLP1 and CLP2, respectively. The extended study on lattice pattern as a reinforcement in columns exhibited an increase in axial load-carrying capacity of BLP with 9.32% and 43.66% when compared with columns with CLP1 and CLP2 reinforcements. Thus, the design inspired from nature leverages advanced technologies such as 3D printing and numerical modeling and suggests the feasibility of implementing glass sponge–inspired patterns in structural engineering, highlighting the efficacy of hierarchical design in contributing to its positive environmental impact and also achieving the UN’s Sustainable Development Goal 9: industry, innovation, and infrastructure.
Protein coding circular RNAs in Human Diseases
Authors: Hu Jintao , Tan Yongmei , Wang Junjie , Kong Degeng , Xu Kewei , Dong Xuesen
Published: January 2025

Circular RNAs (circRNAs) are a unique class of closed-loop RNA molecules formed through back-splicing of precursor mRNAs that exhibit diverse biological functions. Recent evidence highlights their emerging roles as protein-coding entities, particularly in cancer biology. This review explores the cap-independent translation mechanisms of circRNAs, focusing on internal ribosome entry sites and N6-methyladenosine modifications. We further summarize the biological roles of circRNA-encoded proteins and their relevance to human diseases. Additionally, the review addresses key challenges in circRNA research and provides perspectives on their promising potential in disease diagnosis and therapeutic applications.