bluuebunny/crossref_metadata_2025 huggingface dataset:
Response of Hypolimnetic Water and Bottom Sediment Microbial Communities to Freshwater Salinization—A Microcosm Experiment
Authors: Gagnon Jean-Christophe , Blais Valérie Turcotte , Lazar Cassandre Sara
Published: August 2023

The introduction of NaCl in freshwater caused by winter runoffs is a problem whose consequences are still little understood. We sought to analyze the effect of NaCl addition on microbial communities of the hypolimnion and bottom sediments of a Canadian lake. Using microcosms comprising a salinity gradient varying between 0.01 and 3.22 ppt (10–3220 mg/L−1) NaCl, we investigated the effect of salinity on prokaryotic absolute abundance and diversity, following a three- and six-week exposure, and detected the presence of a salinity threshold for microbial communities’ differentiation. We observed a significant decline of bacterial diversity after six weeks in hypolimnetic samples. In the sediments, no clear effect of NaCl was observed on abundance or diversity, despite the presence of variations throughout the salinity gradient. The implication of nutrient fluctuations as well as the co-occurrence of species and inter-domain interactions is likely and would strongly contribute to the development of salt-exposed prokaryotic communities. In hypolimnetic water and sediments, the archaeal and eukaryotic communities differed significantly from 0.93 ppt (930 mg/L−1), while only conclusive at 1.9 ppt (1900 mg/L−1) NaCl in bacteria, meaning that the regulations in place are possibly suitable for the protection of the microbial communities in the hypolimnion and sediment lake layers.
Converged Aesthetics: Blewishness in the Work of Anthony Mordechai Tzvi Russell
Authors: Kaplan Brett Ashley
Published: August 2023

This essay examines the converged aesthetic of Anthony Mordechai Tzvi Russell, focusing on the Kosmopolitan video projects. These videos, and Russell’s work overall, resist the singular terms “Black” and “Jew,” constructing a Blewish converged aesthetic by overlaying images of Josephine Baker or a lonely, lost child walking backward with Russell’s rich and full voice singing Yiddish songs. These remarkable videos, and the projects created by Tsvey Brider (Russell and Dimitri Gaskin), disrupt assumptions about race, gender, sexual orientation, and ethnoreligious affiliation in profound and important ways. I argue that this work performs convergence, thus bucking against the very insistence on antagonism that forms the conditions of possibility for racism.
Enhancing Skin Cancer Detection and Classification in Dermoscopic Images through Concatenated MobileNetV2 and Xception Models
Authors: Ogundokun Roseline Oluwaseun , Li Aiman , Babatunde Ronke Seyi , Umezuruike Chinecherem , Sadiku Peter O. , Abdulahi AbdulRahman Tosho , Babatunde Akinbowale Nathaniel
Published: August 2023

One of the most promising research initiatives in the healthcare field is focused on the rising incidence of skin cancer worldwide and improving early discovery methods for the disease. The most significant factor in the fatalities caused by skin cancer is the late identification of the disease. The likelihood of human survival may be significantly improved by performing an early diagnosis followed by appropriate therapy. It is not a simple process to extract the elements from the photographs of the tumors that may be used for the prospective identification of skin cancer. Several deep learning models are widely used to extract efficient features for a skin cancer diagnosis; nevertheless, the literature demonstrates that there is still room for additional improvements in various performance metrics. This study proposes a hybrid deep convolutional neural network architecture for identifying skin cancer by adding two main heuristics. These include Xception and MobileNetV2 models. Data augmentation was introduced to balance the dataset, and the transfer learning technique was utilized to resolve the challenges of the absence of labeled datasets. It has been detected that the suggested method of employing Xception in conjunction with MobileNetV2 attains the most excellent performance, particularly concerning the dataset that was evaluated: specifically, it produced 97.56% accuracy, 97.00% area under the curve, 100% sensitivity, 93.33% precision, 96.55% F1 score, and 0.0370 false favorable rates. This research has implications for clinical practice and public health, offering a valuable tool for dermatologists and healthcare professionals in their fight against skin cancer.
An EMG-to-Force Processing Approach to Estimating Knee Muscle Forces during Adult, Self-Selected Speed Gait
Authors: Bogey Ross
Published: August 2023

Background: The purpose of this study was to determine the force production during self-selected speed normal gait by muscle–tendon units that cross the knee. The force of a single knee muscle is not directly measurable without invasive methods, yet invasive techniques are not appropriate for clinical use. Thus, an EMG-to-force processing (EFP) model was developed which scaled muscle–tendon unit (MTU) force output to gait EMG. Methods: An EMG-to-force processing (EFP) model was developed which scaled muscle–tendon unit (MTU) force output to gait EMG. Active muscle force power was defined as the product of MTU forces (derived from EFP) and that muscle’s contraction velocity. Net knee EFP moment was determined by summing individual active knee muscle moments. Net knee moments were also calculated for these study participants via inverse dynamics (kinetics plus kinematics, KIN). The inverse dynamics technique used are well accepted and the KIN net moment was used to validate or reject this model. Closeness of fit of the moment power curves for the two methods (during active muscle forces) was used to validate the model. Results: The correlation between the EFP and KIN methods was sufficiently close, suggesting validation of the model’s ability to provide reasonable estimates of knee muscle forces. Conclusions: The EMG-to-force processing approach provides reasonable estimates of active individual knee muscle forces in self-selected speed walking in neurologically intact adults.
Lung Tumor Image Segmentation from Computer Tomography Images Using MobileNetV2 and Transfer Learning
Authors: Riaz Zainab , Khan Bangul , Abdullah Saad , Khan Samiullah , Islam Md Shohidul
Published: August 2023

Background: Lung cancer is one of the most fatal cancers worldwide, and malignant tumors are characterized by the growth of abnormal cells in the tissues of lungs. Usually, symptoms of lung cancer do not appear until it is already at an advanced stage. The proper segmentation of cancerous lesions in CT images is the primary method of detection towards achieving a completely automated diagnostic system. Method: In this work, we developed an improved hybrid neural network via the fusion of two architectures, MobileNetV2 and UNET, for the semantic segmentation of malignant lung tumors from CT images. The transfer learning technique was employed and the pre-trained MobileNetV2 was utilized as an encoder of a conventional UNET model for feature extraction. The proposed network is an efficient segmentation approach that performs lightweight filtering to reduce computation and pointwise convolution for building more features. Skip connections were established with the Relu activation function for improving model convergence to connect the encoder layers of MobileNetv2 to decoder layers in UNET that allow the concatenation of feature maps with different resolutions from the encoder to decoder. Furthermore, the model was trained and fine-tuned on the training dataset acquired from the Medical Segmentation Decathlon (MSD) 2018 Challenge. Results: The proposed network was tested and evaluated on 25% of the dataset obtained from the MSD, and it achieved a dice score of 0.8793, recall of 0.8602 and precision of 0.93. It is pertinent to mention that our technique outperforms the current available networks, which have several phases of training and testing.
Assessing the Genotoxicity of Cellulose Nanomaterials in a Co-Culture of Human Lung Epithelial Cells and Monocyte-Derived Macrophages
Authors: Ventura Célia , Pinto Fátima , Lourenço Ana Filipa , Pedrosa Jorge F. S. , Fernandes Susete N. , da Rosa Rafaela R. , Godinho Maria Helena , Ferreira Paulo J. T. , Louro Henriqueta , Silva Maria João
Published: August 2023

Cellulose micro/nanomaterials (CMNMs) are innovative materials with a wide spectrum of industrial and biomedical applications. Although cellulose has been recognized as a safe material, the unique properties of its nanosized forms have raised concerns about their safety for human health. Genotoxicity is an endpoint that must be assessed to ensure that no carcinogenic risks are associated with exposure to nanomaterials. In this study, we evaluated the genotoxicity of two types of cellulose micro/nanofibrils (CMF and CNF) and one sample of cellulose nanocrystals (CNC), obtained from industrial bleached Eucalyptus globulus kraft pulp. For that, we exposed co-cultures of human alveolar epithelial A549 cells and THP-1 monocyte-derived macrophages to a concentration range of each CMNM and used the micronucleus (MN) and comet assays. Our results showed that only the lowest concentrations of the CMF sample were able to induce DNA strand breaks (FPG-comet assay). However, none of the three CMNMs produced significant chromosomal alterations (MN assay). These findings, together with results from previous in vitro studies using monocultures of A549 cells, indicate that the tested CNF and CNC are not genotoxic under the conditions tested, while the CMF display a low genotoxic potential.
Central Autonomic Network Regions and Hypertension: Unveiling Sympathetic Activation and Genetic Therapeutic Perspectives
Authors: Geraldes Vera , Laranjo Sérgio , Nunes Catarina , Rocha Isabel
Published: August 2023

Introduction: Hypertension, a leading cause of death, was investigated in this study to understand the role of specific brain regions in regulating blood pressure. The lateral parabrachial nucleus (LPBN), Kolliker-fuse nucleus (KF), and periductal grey matter (PAG) were examined for their involvement in hypertension. Methods: Lentiviral vectors were used to alter the activity of these brain regions in hypertensive rats. Over a 75-day period, blood pressure, heart rate, reflex responses, and heart rate variability were measured. Results: Decreasing the activity in the LPBN resulted in a reduced sympathetic outflow, lowering the blood pressure and heart rate. In the KF, the sympathetic activity decreased and chemoreflex variation was attenuated, without affecting the blood pressure. Silencing the PAG had no significant impact on blood pressure or sympathetic tone, but decreased cardiac baroreflex gain. Discussion: These findings highlight the significant role of the LPBN in hypertension-related sympathetic activation. Additionally, LPBN and KF neurons appear to activate mechanisms that control respiration and sympathetic outflow during chemoreceptor activation. Conclusions: The study provided insights into the contribution of the midbrain and pontine regions to neurogenic hypertension and offers potential avenues for future genetic interventions and developing novel treatment approaches.
High-Throughput Antibody Profiling Identifies Targets of Protective Immunity against P. falciparum Malaria in Thailand
Authors: Hassan Ifra , Kanoi Bernard N. , Nagaoka Hikaru , Sattabongkot Jetsumon , Udomsangpetch Rachanee , Tsuboi Takafumi , Takashima Eizo
Published: August 2023

Malaria poses a significant global health challenge, resulting in approximately 600,000 deaths each year. Individuals living in regions with endemic malaria have the potential to develop partial immunity, thanks in part to the presence of anti-plasmodium antibodies. As efforts are made to optimize and implement strategies to reduce malaria transmission and ultimately eliminate the disease, it is crucial to understand how these interventions impact naturally acquired protective immunity. To shed light on this, our study focused on assessing antibody responses to a carefully curated library of P. falciparum recombinant proteins (n = 691) using samples collected from individuals residing in a low-malaria-transmission region of Thailand. We conducted the antibody assays using the AlphaScreen system, a high-throughput homogeneous proximity-based bead assay that detects protein interactions. We observed that out of the 691 variable surface and merozoite stage proteins included in the library, antibodies to 268 antigens significantly correlated with the absence of symptomatic malaria in an univariate analysis. Notably, the most prominent antigens identified were P. falciparum erythrocyte membrane protein 1 (PfEMP1) domains. These results align with our previous research conducted in Uganda, suggesting that similar antigens like PfEMP1s might play a pivotal role in determining infection outcomes in diverse populations. To further our understanding, it remains critical to conduct functional characterization of these identified proteins, exploring their potential as correlates of protection or as targets for vaccine development.
Improvement of the Physicochemical Limitations of Rhapontigenin, a Cytotoxic Analogue of Resveratrol against Colon Cancer
Authors: Navarro-Orcajada Silvia , Vidal-Sánchez Francisco José , Conesa Irene , Matencio Adrián , López-Nicolás José Manuel
Published: August 2023

It has been argued that methoxylated stilbenes are better candidates for oral administration than hydroxylated stilbenes, including resveratrol, as they share many biological activities but have better bioavailability. By contrast, they have a disadvantage to consider, i.e., their lower hydrophilic character that leads to precipitation issues in the final product. In this work, we analysed and compared the growth inhibition of colorectal cancer cells of the methoxylated stilbene rhapontigenin and some analogues and overcame potential problems in the development of fortified products by designing inclusion complexes. Among several cyclodextrins, we found the one that best fit the molecule by physicochemical and bioinformatics assays. The stoichiometry and the encapsulation constants with natural and modified cyclodextrins were determined by fluorescence spectroscopy. The most promising complexes were analysed at different temperature and pH conditions, determining the thermodynamic parameters, to discover the optimal conditions for the preparation and storage of the products. The results showed that rhapontigenin solubility and stability were significantly improved, achieving a sevenfold increase in water solubility and maintaining more than 73% of the stilbene after three months. These findings could be of great interest for industries that aim to deliver novel bioactive compounds with higher solubility and lower degradation.
Cantharidin-Based Verbenone Derivatives as a Novel Insecticide against Plutella xylostella: Design, Synthesis, Insecticidal Activity Evaluation, and 3D QSAR Study
Authors: Lee Kwanshik , Nada Hossam , Kim Minkyoung , Park Hyejun , Lee Kiho , Seo Dongho , Lee Kyeong , Choi Yongseok
Published: August 2023

The diamondback moth is a detrimental insect pest of brassicaceous crops which was among the first crop insects to be reported as DDT resistant. It has since proven to be significantly resistant to nearly every synthetic insecticide used in the field in many crucifer-producing regions. Due to insecticide control failures in some parts of the world, economically viable crucifer production is now all but impossible. As a result, there has been an increasing effort to identify new compounds with strong pesticidal activity. Cantharidin is one such compound that has been shown to be highly effective against a variety of insect pests. However, its chemical synthesis and potential toxicity to non-target organisms have been a major source of concern. Herein, using rational design approaches, a new series of cantharidin-based verbenone derivatives were synthesized and evaluated for their insecticidal activities against the diamondback moth. Among different compounds screened, compounds 6a, 6h, 6i, and 6q emerged as the most potent compounds exhibiting 100% mortality at a concentration of 100 mg/L after four days. These compounds demonstrated a good anti-feeding effect against the diamondback moth on cabbage leaves. Subsequently, a 3D QSAR study was carried out to identify the key structural features of the synthesized compounds and their correlation with insecticidal activity.
Comprehensive Assessment of Mid-Regional Proadrenomedullin, Procalcitonin, Neuron-Specific Enolase and Protein S100 for Predicting Pediatric Severe Trauma Outcomes
Authors: Zakirov Rustam , Petrichuk Svetlana , Yanyushkina Olga , Semikina Elena , Vershinina Marina , Karaseva Olga
Published: August 2023

The development of multiple organ failure and septic complications increases the cumulative risk of mortality in children with severe injury. Clinically available biochemical markers have shown promise in assessing the severity and predicting the development of complications and outcomes in such cases. This study aimed to determine informative criteria for assessing the severity and outcome prediction of severe injury in children based on levels of mid-regional proadrenomedullin (MR-proADM) procalcitonin (PCT), neuron-specific enolase (NSE), and protein S100. Biomarker levels were measured in 52 children with severe injury (ISS ≥ 16) on the 1st, 3rd, 7th, and 14th days after admission to the ICU. The children were divided into groups based on their favorable (n = 44) or unfavorable (n = 8) outcomes according to the Severe Injury Outcome Scale, as well as their favorable (n = 35) or unfavorable (n = 15) outcomes according to the Glasgow Coma Outcome Scale (GOS). The study also evaluated the significance of biomarker levels in predicting septic complications (with SC (n = 16) and without SC (n = 36)) and diagnosing and stratifying multiple organ failure (with MOF (n = 8) and without MOF (n = 44)). A comprehensive assessment of MR-proADM and PCT provided the highest diagnostic and prognostic efficacy for early diagnosis, risk stratification of multiple organ failure, and outcome prediction in severe injury cases involving children. Additionally, the inclusion of the S100 protein in the study allowed for further assessment of brain damage in cases of traumatic brain injury (TBI), contributing to the overall prognostic model.
Central Pattern Generator (CPG)-Based Locomotion Control and Hydrodynamic Experiments of Synergistical Interaction between Pectoral Fins and Caudal Fin for Boxfish-like Robot
Authors: Chen Lin , Cai Yueri , Bi Shusheng
Published: August 2023

Locomotion control of synergistical interaction between fins has been one of the key problems in the field of robotic fish research owing to its contribution to improving and enhancing swimming performance. In this paper, the coordinated locomotion control of the boxfish-like robot with pectoral and caudal fins is studied, and the effects of different control parameters on the propulsion performance are quantitatively analyzed by using hydrodynamic experiments. First, an untethered boxfish-like robot with two pectoral fins and one caudal fin was designed. Second, a central pattern generator (CPG)-based controller is used to coordinate the motions of the pectoral and caudal fins to realize the bionic locomotion of the boxfish-like robot. Finally, extensive hydrodynamic experiments are conducted to explore the effects of different CPG parameters on the propulsion performance under the synergistic interaction of pectoral and caudal fins. Results show that the amplitude and frequency significantly affect the propulsion performance, and the propulsion ability is the best when the frequency is 1 Hz. Different phase lags and offset angles between twisting and flapping of the pectoral fin can generate positive and reverse forces, which realize the forward, backward, and pitching swimming by adjusting these parameters. This paper reveals for the first time the effects of different CPG parameters on the propulsion performance in the case of the synergistic interaction between the pectoral fins and the caudal fin using hydrodynamic experimental methods, which sheds light on the optimization of the design and control parameters of the robotic fish.
The Mediating Effects of Social Networks and Wisdom on the Relationship between Lifestyle Habits and Healthy Aging in Older Adults with Chronic Diseases
Authors: Kim Hee-Kyung , Oh Hye-Suk , Park Cheol-Hee
Published: August 2023

Background: The purpose of this study was to analyze the mediating effects of social networks and wisdom on the relationship between lifestyle habits and healthy aging in older adults with chronic diseases. Methods: Participants were 120 community-dwelling older adults aged 65 and older with at least one chronic disease. Data were collected from elderly people by visiting nursing care worker training centers, senior centers, social gatherings, and home welfare centers in D, G, and S cities, with a questionnaire of lifestyle habits, social networks, wisdom and healthy aging, and general characteristics. Results: There were differences in the degree of healthy aging according to age (F = 3.76, p = 0.026), spousal relationship (t = 3.11, p = 0.002), education (F = 9.08, p < 0.001), number of diseases (F = 8.65, p < 0.001), and economic level (t = −2.45, p = 0.016). The most common diseases among the subjects were hypertension, hyperlipidemia, joint diseases and diabetes mellitus. Social networks (β = 0.46, p < 0.001) and wisdom (β = 0.55, p < 0.001) had partial mediating effects (z = 4.15, p < 0.001; z = 5.11, p < 0.001) on the relationship between subjects’ lifestyle habits and healthy aging. Conclusions: To increase the degree of healthy aging of subjects, it is necessary to establish a mediating intervention program that manages to have good lifestyle habits in daily life, increase social networks, and become wise.
Factors Affecting Purchase Intention of Hanfu: Considering Product Identification, Cultural Motivation, and Perceived Authenticity
Authors: Li Xianyue , Niu Yongge , Xu Jiuping
Published: August 2023

With the trend of national cultural confidence and the growing appreciation for aesthetic diversity, traditional apparel from different countries or regions has become a driving force in the clothing industry. Hanfu, an emerging trend that industrializes traditional culture, has garnered increasing attention from consumers. Thus, with the objective of exploring the psychological antecedents of Hanfu consumers’ purchase intentions from the perspectives of product identification, cultural motivation, and consumers’ perceived authenticity, the present study was empirically conducted with a sample of 823 respondents. Partial least squares-structural equation modeling (PLS-SEM) was employed to examine the proposed research model. The results demonstrate that consumers’ identification with Hanfu and cultural motivation positively influence object-based and existential authenticity, as well as purchase intention. Furthermore, the mediating effect of perceived object-based authenticity is confirmed, indicating its significance in shaping consumers’ purchase intentions, while the mediating effect of existential authenticity is found to be insignificant. Research findings could contribute to the understanding of the psychological mechanisms driving consumers’ purchase intentions towards traditional clothing and highlight the importance of consumers’ perceived object-based authenticity in the market of traditional cultural clothing.
Child ViReal Support Program: A Randomized Controlled Trial Study for Effective Support of Parents Raising Children with Attention Deficits
Authors: Pachiti Iouliani , Milienos Fotios S. , Dimitropoulou Panagiota
Published: August 2023

Attention deficit hyperactivity disorder (ADHD) results in various functioning impairments in children’s lives and families. Parents of children with ADHD report high levels of parenting stress, low levels of parental self-efficacy, and use of more authoritarian and/or permissive parenting practices than parents of typically developing children. Intervention programs need to address both children’s and parents’ needs and multimodal intervention programs could cover this demand. The aim of this study was to examine the efficacy of “Child ViReal Support Program”—a multi-level evidence-based comprehensive program—on parenting stress, parental self-efficacy, parenting practices, and the core symptoms of children’s ADHD. Families with a child diagnosed with ADHD (n = 16) were randomly allocated to two groups (PC and CP; P = parent training, C = child training), and a cross-over design was utilized. Participating parents completed, in four different times during the study, the Parenting Stress Index-Short Form, the Parenting Sense of Competence Scale, the Parenting Styles and Dimensions Questionnaire-Short Version, and the parent form of the ADHD Rating Scale-IV. Parents from both groups, after their participation in the parent training, demonstrated reduced parenting stress, enhanced parental self-efficacy, and increased the employ of democratic parenting practices. More than that, they reported decreased levels of inattention and impulsivity/hyperactivity for their children. Evidence-based multi-level intervention programs could produce positive effects on parents and children by incorporating effective methods and tools in accordance with the needs and the demands of the family context.
Factors Influencing the Purchase Intention for Online Health Popular Science Information Based on the Health Belief Model
Authors: Liu Jingfang , Wang Shiqi
Published: August 2023

There is a growing demand for health popular science information from the public. Online paid health popular science information provides a new channel for the public to obtain health popular science information and can meet users’ demands for high-quality health popular science information. In order to improve the popularity of online paid health popular science information, it is urgent to investigate the factors influencing users’ intention to pay for online health popular science information. Paid online health popular science information can provide users with higher-quality health knowledge, while monetary compensation can incentivize publishers to create and promote the sustainability of social media platforms. Therefore, paid online health popular science information is important for readers, creators, and platforms. Therefore, this study investigates the factors influencing users’ intentions to purchase online health popular science information based on the health belief model (HBM). Our research data were obtained by a questionnaire and empirically analyzed by SmartPLS structural equation modeling. The results of this study indicate that the greater the perceived susceptibility, severity, and irreplaceability of health problems, the greater the intention of users to purchase health information when they read the summary portion of paid online health popular science information. And the higher the perceived risk and the more unreasonable the price of the online health popular science information, the lower the intention to purchase. Moreover, both the perceived susceptibility and perceived severity significantly attenuated the negative impacts of perceived health popular science information risk and perceived price unreasonableness on users’ intentions to purchase online health popular science information. This study not only enriches and extends the application of the health belief model, but also has important positive implications for the development of online paid health popular science information.
Mental Health of People with Intellectual Disabilities Living in Residential Care before, during, and after Lockdown
Authors: Gil-Llario María Dolores , Díaz-Rodríguez Irene , Fernández-García Olga , Estruch-García Verónica , Bisquert-Bover Mar , Ballester-Arnal Rafael
Published: August 2023

Background: The impact of the COVID-19 on the well-being of people with intellectual disabilities (PID) has been little studied. Methods: We analyzed its impact with a cohort study quantitatively analyzing anxiety, depression, organic symptoms, quality of life, and support needs in 24 PID, aged 19–74 years (x¯ 40, σ = 13.09), living in a residential center, before, during, and after the pandemic. Results: Their mental health improved unexpectedly at the onset of the lockdown although there was an increase in organic symptoms. But, with the progress of the lockdown, their mental health deteriorated drastically. On the contrary, as expected, their quality of life and support needs worsened from the beginning of the lockdown until the country returned to normality, a time when there was a general recovery, without reaching pre-pandemic levels. These results show that the mental health of PID was affected differently to that of people without intellectual disabilities.
Do Pictograms on Medication Packages Cause People to Consult Package Inserts Less Often? If so, With What Consequences?
Authors: Reijnen Ester , Laasner Vogt Lea , Kühne Swen J. , Fiechter Jan P.
Published: August 2023

Overall, pharmaceutical pictograms seem to improve medication adherence. However, little is known about how warning pictograms (e.g., “do not drive after taking”) on medication packages influence patients’ information-seeking strategies such as consulting the package insert (PI) to determine other features such as the correct dosage. In this online study, participants (358 students) were presented with three fictitious scenarios (e.g., headache after alcohol consumption; factor scenario) in which medication use would be contraindicated. Each scenario was accompanied by a visual presentation of a medication package that could contain three possible pictogram selections or arrangements (factor warning); some arrangements contained pictograms relevant to the situation represented by the scenario, while others did not. Participants had to decide which dosage of the represented medication they were allowed to take in the given scenario. In making this decision, they could consult the PI or not. Overall, in two out of the three scenarios (driving and pregnancy), medication packages with relevant pictograms resulted in fewer PI consultations but led to more correct dosage decisions (“no pill”) than packages with irrelevant pictograms. Pictograms generally played no role in either the review of the PI consultation or dosage decisions in the alcohol scenario. Providing warning-relevant pictograms on medication packages can help people know when they should not take medication even without reading the PI.
BIM Manager Role in the Integration and Coordination of Construction Projects
Authors: Sampaio Alcínia Zita , Azevedo Gonçalo , Gomes Augusto
Published: August 2023

Building information modelling (BIM) methodology has been implemented in the construction industry, reaching all sectors: multidisciplinary design development; construction planning and monitoring; and building management and maintenance. A complete BIM project aggregates several disciplines and different professionals skillsets. In order to achieve a suitable control, contributing to improve the quality of the project, a BIM manager is required. The BIM manager has the responsibility to coordinate all tasks involved in a building design, as well as the associated activities usually that are normally worked-out, complementing the project. During the development of a project, a BIM manager can access various discipline models, located in a delayering shared platform, and request responsibilities and amendments if inconsistencies are detected. The relevance of the BIM manager function is illustrated with three building cases where distinct specific projects, disciplines, and tasks were elaborated: collaboration between disciplines (architecture, structures, and construction); structural analyses and reinforcement details; quantity take-off of materials and cost estimation; construction scheduling and simulation. Although there are limitations in the software interoperability capacity, within the elaboration of a multiple stage project, BIM implementation in the construction industry has been carried out. The present study shows that the BIM manager role in projects aggregates several disciplines and experts, bringing an important improvement in the quality of the final product. A suitable BIM implementation in the construction industry needs to be supported by the most current advanced technology and in adequate BIM manager coordination.
Study on Force Characteristics and Safety of Segment Structure and Bolts with and without Cavity behind Lining with Multi-Field Coupling
Authors: Li Feilong , Jiang Changshan , Cai Guoqing , Luo Jianjun , Yu Qian , Zhang Heqing , Wang Lei
Published: August 2023

In this study, a refined three-dimensional stratigraphic–structural model is established based on ABAQUS finite element software, and the basis for determining pneumatic and vibration loads is explained in detail. From this, the force characteristics of the segment and bolts with and without a cavity behind the lining under the action of multi-field coupling were analyzed, and the force law and corresponding safety of the segment structure and high-strength bolts were determined. The results show that the peak value of the maximum principal stress on the segment structure caused by the surrounding rock pressure was 92.7 times greater than the variation in the peak value of the maximum principal stress caused by additional loads (pneumatic and vibration loads). Despite this, the safety factor of the segment structure satisfied the code requirements. Compared to the situation with no cavity behind the lining, when the cavity behind the lining was small the stresses of the segment structure were large and concentrated, which increased the possibility of crack development in the segment structure. The nodal stresses and strains on the straight and bending bolts exhibited an approximately “W”-shaped distribution with a cavity behind the lining. In addition to the effect of the preload near the nut, the stress and strain at the central measurement point of the bolt rod at the joint face were larger owing to the coupling effect of multiple fields. The high-strength bolt remained in an elastic state and did not yield with damage.
Optimal Sizing and Management of Hybrid Renewable Energy System for DC-Powered Commercial Building
Authors: Olabi Abdul Ghani , Ghoniem Rania M. , Alami Abdul Hai , Abdelkareem Mohammad Ali
Published: August 2023

DC power may be more efficient than AC power in certain applications, especially when it comes to local generation and storage. This is because AC power requires extra equipment to convert it to DC power, which can lead to energy losses. Using DC power, on the other hand, makes it easier for devices to use it directly, resulting in higher energy efficiency. Additionally, using DC power can reduce equipment capital costs as it eliminates the need for additional AC–DC conversion equipment. Finally, DC power systems can offer new communication capabilities, including plug-and-play for generation and storage devices, making it simpler to integrate these systems into existing infrastructure. This paper analyzes the optimal size of a photovoltaic/PEM fuel cell system to supply a certain DC commercial load in NEOM city. To identify the best size of the PV/PEMFC, minimizing the cost of energy (COE) and minimizing the net present cost (NPC) are considered. The paper studies three sizes of PEMFCs: 15 kW, 20 kW, and 25 kW. In addition, five different PV modules are selected: Axitec 450 Watt, Jinko 415 Watt, REC Solar 410 Watt, Seraphim 310 Watt, and Tongwei 415 Watt. The results of the study confirmed that the best size of the hybrid system comprises a 15 kW PEMFC, a 267 kW Tongwei PV array, a 60 kg electrolyzer, and a 20 kg hydrogen tank. Under these conditions, the COE and NPC are 0.293 USD/kWh and 498,984 USD, respectively.
Non-Linear Behavior and Design of Steel Structures: Review and Outlook
Authors: Zhang Zhi-Jian , Chen Bai-Sen , Bai Rui , Liu Yao-Peng
Published: August 2023

The high strength and stiffness-to-weight ratios of structural steel often result in relatively slender members and systems, which are governed to a great extent by stability limit states. However, predicting the stability of slender structures is difficult due to various inherent uncertainties in material and geometry. Generally, structural and member stabilities are nonlinear problems that cannot be directly evaluated based on the section strength using conventional analysis method. Nonlinear behaviors are basically categorized as materially and geometrically nonlinear, which can be observed at the cross-sectional, member, and frame levels. To provide a comprehensive understanding of the current state-of-the-art non-linear behavior and design of steel structures and to identify key areas for future research and development, this paper presents a review on the materially and geometrically nonlinear effects of steel structures. A discussion of the effects of material yielding accentuated by the presence of residual stresses, initial imperfections, and end conditions will be conducted. The stiffness reduction due to second-order effects and material yielding will be illustrated. Moreover, current and emerging design approaches that consider nonlinear responses will also be reviewed and evaluated. Lastly, with the development of modern flexible and complex steel structures, which sometimes violate fundamental assumptions of the current stability design method, the application of advanced analysis and design methods will be explored.
Effects of Different Nocturnal Lighting Stimuli on Melatonin, Sleep and Cognitive Performance of Workers in Confined Spaces
Authors: Wang Tongyue , Shao Rongdi , Hao Luoxi
Published: August 2023

Exposure to light during overtime work at night in confined spaces may disrupt the normal circadian clock, affect hormone secretion, sleep quality and performance, thereby posing great risks to the physical and mental health of night workers. Integrative lighting should be adopted to reduce the disturbance of normal physiological rhythm, while meeting the visual requirements of work. Through adjustable LED (CCT 6000 K/2700 K) and different vertical illuminance, five lighting patterns with different circadian stimuli (CS = 0.60, 0.30. 0.20, 0.10 and 0.05) were conducted, respectively, in a sleep lab using a within-subject design. Each lighting pattern lasted for 5 h every night. Eight healthy adults were recruited to complete the night work and their salivary melatonin, Karolinska sleepiness scale (KSS), Psychomotor Vigilance Task (PVT) and sleep quality were tested. The results showed that subjective sleepiness and melatonin concentration increased rapidly under low intervention (CS = 0.05) with the best sleep quality, while they decreased in high intervention (CS = 0.60) at night and led to significantly higher levels of sleepiness the next morning (p < 0.05). For the PVT, the middle intervention (CS = 0.30) showed the lowest response time and least errors (p < 0.05), suggesting that appropriate illuminance can improve visual performance. To reduce biorhythm disruptions, lower lighting stimulation is preferred during night work. For difficult visual tasks, high illuminances may not improve visual performance; just a slight increase in the existing lighting levels is adequate. Lighting interventions have a clear impact on sleep improvement and work capacity for those working overtime, and they may be translatable to other shift work scenarios.
An Experimental Study on Plate Splicing of Prefabricated Plate Foundation
Authors: Wang Wenming , Gao Yahui , Wang Zhen , Zhang Lijuan , An Zhonghai , Shao Sicheng
Published: August 2023

Tower foundations are generally of a cast-in-place structure with the disadvantages of low industrialization level and long construction period. The development of prefabricated foundation for transmission line projects is efficient to improve the industrialization level of the construction of tower foundation. In this study, the schemes of post-pouring belt U-shaped steel connection, post-pouring belt lap connection, grouting sleeve connection, and post-tensioned bond prestressed reinforcement connection, which have been widely used on building structures, are newly proposed to apply on plate foundation. The schemes were compared on processing, transporting, on-site constructing and performance. The pseudo-static tests on cast-in-place plate strip, post-pouring belt U-shaped steel connection and post-pouring belt lap connection plate strip were carried out. The results revealed that all the test plate bands were damaged in the bending mode, same as that of ordinary concrete. When U-shaped steel is adopted, more than 90% of the cast-in-place bearing capacity can be reached. The initial stiffness of prefabricated plate strip and cast-in-place strip is basically the same. The load-bearing capacity of the component is relevant to the anchorage length of the U-shaped steel. Although increasing the concrete strength of post-cast belt can improve the ultimate bearing capacity and shorten the construction period, the deformation capacity is reduced. Compared to other connection methods, post-pouring belt U-shaped steel connections have the advantage of simple construction, higher bearing capacity and stability. In summary, the post-pouring belt U-shaped steel connection scheme is recommended.
Mechanical Properties of SMA/PVA-ECC under Uniaxial Tensile Loading
Authors: Yang Zhao , Li Jiankun , Zhong Yilan , Qi Xiaolong
Published: August 2023

Although shape memory alloy/Polyvinyl alcohol (SMA/PVA) hybrid fiber reinforced cementitious composites, (SMA/PVA-ECC) exhibit excellent crack closure and deformation recovery capabilities, however, the research on their fundamental mechanical properties is still limited. This study investigates the tensile mechanical properties of SMA/PVA-ECC materials by conducting uniaxial tensile tests, analyzing the failure behavior, stress–strain curves, and characteristic parameters of the specimens, comparing the influence of SMA fiber content and diameter, and establishing a tensile constitutive model. The results show that the residual crack width of SMA/PVA-ECC specimens significantly decreases after unloading, and SMA fiber content and diameter have a significant impact on the tensile properties of the specimens. The comprehensive tensile properties of specimens with a fiber diameter of 0.2 mm and content of 0.2% are the best, with their initial cracking strength, ultimate strength, and strain increasing by 56.4%, 23.6%, and 13.4%, respectively, compared to ECC specimens. The proposed bilinear tensile constitutive model has high accuracy. This study provides a theoretical basis for further research on SMA/PVA-ECC materials.
Divergence in Antiviral Activities of Carbon Dots versus Nano-Carbon/Organic Hybrids and Implications
Authors: Rodriguez Cristian E. , Adcock Audrey F. , Singh Buta , Yerra Subhadra , Tang Yongan , Sun Ya-Ping , Yang Liju
Published: August 2023

Carbon dots (CDots) are generally defined as small carbon nanoparticles (CNPs) with effective surface passivation, for which the classical synthesis is the functionalization of pre-existing CNPs with organic molecules. However, “dot” samples produced by “one-pot” thermal carbonization of organic precursors are also popular in the literature. These carbonization-produced samples may contain nano-carbon domains embedded in organic matters from the precursors that survived the thermal processing, which may be considered and denoted as “nano-carbon/organic hybrids”. Recent experimental evidence indicated that the two different kinds of dot samples are largely divergent in their photo-induced antibacterial functions. In this work, three representative carbonization-produced samples from the precursor of citric acid–oligomeric polyethylenimine mixture with processing conditions of 200 °C for 3 h (CS200), 330 °C for 6 h (CS330), and microwave heating (CSMT) were compared with the classically synthesized CDots on their photo-induced antiviral activities. The results suggest major divergences in the activities between the different samples. Interestingly, CSMT also exhibited significant differences between antibacterial and antiviral activities. The mechanistic origins of the divergences were explored, with the results of different antimicrobial activities among the hybrid samples rationalized in terms of the degree of carbonization in the sample production and the different sample structural and morphological characteristics.
Immunotherapy in Melanoma: Recent Advancements and Future Directions
Authors: Mooradian Meghan J. , Sullivan Ryan J.
Published: August 2023

Immune checkpoint inhibition has fundamentally altered the treatment paradigm of resectable and unresectable melanoma, resulting in dramatic improvements in patient outcomes. With these advances, the five-year overall survival in patients with newly diagnosed unresectable disease has eclipsed 50%. Ongoing research is focused on improving outcomes further, with a considerable emphasis on preventing de novo and acquired resistance and personalizing therapeutic options. Here, we review the ongoing advancements in the treatment of malignant melanoma, focusing on novel combination strategies that aim to build upon the successes of the last decade.
Zeolitic Imidazolium Frameworks-Derived Ru-Based Composite Materials Enable the Catalytic Dehydrogenation of Alcohols to Carboxylic Acids
Authors: Chen Zhan , Hang Jing , Zhang Song , Yuan Ye , Verpoort Francis , Chen Cheng
Published: August 2023

The metal-catalyzed dehydrogenation of alcohols without any oxidant or additive has been demonstrated as an atom-economic and environmentally friendly strategy for carboxylic acid synthesis. Among the various catalysts applied to this transformation, Ru-based homogeneous ones have been the most extensively studied owing to their remarkable catalytic activity. However, these catalysts required multiple complicated synthesis steps. In addition, they were either difficult to recycle or their recovery processes were relatively tedious. Therefore, a series of Ru-containing heterogeneous catalysts with zeolitic imidazolium frameworks (ZIFs)-derived materials were designed and fabricated. A thorough screening of various parameters was conducted, and it was found that the material obtained by loading a Ru concentration of 0.05 mol/L into Co species embedded in porous N-doped carbon (Ru0.05@Co-NC) had the best catalytic performance in this transformation, affording a handful of carboxylic acid products from the corresponding aromatic or aliphatic alcohols in moderate to high yields. Additionally, the catalyst showed remarkable recyclability as it could be recycled eight times with stable activity fluctuation (45–52%). It is noteworthy that catalyst recycling was convenient and fast, which could be realized simply by an external magnet. Moreover, the stable morphology and structure of Ru0.05@Co-NC, along with its high specific surface area, hierarchical pore structure, high porosity, and other properties, jointly contributed to its high catalytic activity and good recyclability. Furthermore, the stability and activity of Ru0.05@Co-NC were further evaluated through acid etching experiments, which revealed that some Ru species could stably exist in concentrated acids and play a pivotal role in promoting this catalytic process.