bluuebunny/crossref_metadata_2025 huggingface dataset:
Results of Five-Year Outpatient Follow-Up of Patients With Heart Failure in a Specialized Center
Authors: Vinogradova N. G. , Polyakov D. S. , Fomin I. V. , Vaisberg A. R. , Pogrebetskaya V. A.
Published: December 2024

Aim    To evaluate the risks of all-cause death (ACD), cardiovascular death (CVD), death from recurrent acute decompensated heart failure (ADHF), and a composite index of CVD and death from recurrent ADHF in patients with chronic heart failure (CHF) after the first hospitalization for ADHF during a long-term, five-year follow-up in the conditions of specialized medical care and in real clinical practice.Material and methods    This prospective cohort observational study included 942 patients after ADHF. Group 1 consisted of 510 patients who continued the outpatient follow-up at a specialized center for the treatment of CHF (cCHF); group 2 consisted of 432 patients followed up at outpatient and polyclinic institutions (OPI) at the place of residence. During the five-year follow-up, the causes of death were determined based on the medical records of inpatients, postmortem examinations, or the conclusion in the medical records of outpatients. Rates of ACD, CVD, death from recurrent ADHF, and the composite index (CVD and death from ADHF) were analyzed. Statistical analysis was performed with a R statistical package.Results    ACD was 32.3% and 53.5% in groups 1 and 2, respectively (p<0.001). Based on the results of Cox proportional hazards models, it was shown that the follow-up in group 1, regardless of other factors, was associated with a decrease in the ACD risk (HR 2.07; 95% CI 1.68-2.54; p<0.001), CVD (HR 1.94; 95% CI 1.26-2.97; p=0.002), death from recurrent ADHF (HR 2.4; 95% CI 1.66–3.42; p<0.001) and the composite mortality index (HR 2.2; 95% CI 1.65-2.85; p<0.001) compared to group 2. The risks of death in CHF patients with moderately reduced left ventricular ejection fraction (LVEF) (HFmrEF) were consistent with the death rates in CHF patients with low LVEF (HFrEF) and were significantly higher than in CHF patients with preserved LVEF (HFpEF). The prognosis of life worsened with an increase in the Clinical Condition Assessment Scale score and age. The prognosis of life was better in women, as well as with higher values of systolic blood pressure (BP) and 6-minute walk test. In the structure of death in both groups, death from ADHF and sudden cardiac death (SCD) prevailed.Conclusion    The absence of specialized follow-up at an outpatient CHF center increases the risks of ACD, CVD, death from recurrent ADHF, and the composite endpoint at a depth of five-year observation. The leading causes of death were recurrent ADHF and SCD.
The Role of the Left Atrium in the Pathogenesis of Heart Failure With Preserved Ejection Fraction
Authors: Ovchinnikov A. G. , Potekhina A. V. , Filatova A. Yu. , Svirida O. N. , Shogenova M. Kh. , Sobolevskaya M. S. , Ageev F. T.
Published: December 2024

Left atrial dysfunction (left atrial myopathy) is not only a consequence of impaired left ventricular diastolic function but also plays a central role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF). Left atrial myopathy in HFpEF is associated with a more severe course of heart failure and an unfavorable prognosis, and the choice of treatment largely depends on its severity. Echocardiography allows an accurate assessment of the left atrial condition, while the parameters of left atrial myocardial strain are sensitive to early functional disorders to help diagnosing HFpEF and determining the prognosis. This article discusses the participation of the left atrium in the left ventricular filling, its status at different stages of left ventricular diastolic dysfunction, the major mechanisms of atrial myopathy in HFpEF, and therapeutic approaches to its restriction and reversion.
DẠY HỌC NỘI DUNG PHƯƠNG TRÌNH THEO ĐỊNH HƯỚNG GIÁO DỤC STEM
Authors: Đình Phượng Vũ
Published: December 2024

This paper studies the teaching of mathematics in the direction of STEM education. With theoretical methods, this paper presents the components of STEM and the relationship between Mathematics and the other components of STEM. Based on the processes of designing STEM lessons developed by other authors, this paper proposes the process of designing STEM lessons in teaching mathematical equations and gives an example of using this process in teaching specific mathematics content.
EXPLORING EFL TEACHERS’ PERCEPTIONS OF NEW TEXTBOOK UTILIZATION IN HIGH SCHOOL SETTINGS
Authors: Ky Nhan Lam , Hoang Yen Phuong
Published: December 2024

This study investigates the perceptions of 43 English as a Foreign Language (EFL) teachers regarding the benefits and challenges associated with using new textbooks in high school settings. The research employs a combination of questionnaire surveys and semi-structured interviews to explore teachers’ perceptions and experiences. It aims to uncover the anticipated benefits of integrating new textbooks, such as providing updated content, adopting more effective teaching methods, and enhancing student engagement. The study also addresses key challenges, including resistance to change, inadequate teacher training, and difficulties in aligning new materials with curricular goals. Additionally, it examines how these perceptions influence teaching methods and curriculum implementation strategies. The findings contribute to a deeper understanding of the role of new textbooks in EFL high school environments, offering valuable insights for developing language education curricula, instructional approaches, and professional development programs.
DEVELOPING COMPETENCY FRAMEWORK FOR ORGANIZING STEAM EDUCATION ACTIVITIES FOR EARLY CHILDHOOD EDUCATION STUDENTS
Authors: Lan Anh Dinh
Published: December 2024

The ability to organize STEAM education activities plays an important role in preparing students majoring in Early Childhood Education (ECE) to meet the requirements of their training program and the general development trend of modern society. Therefore, the development of a specific STEAM educational competency framework for Early Childhood Education students is an essential step in improving the quality of teaching and preparing for the challenges of the contemporary educational environment. This paper presents constructing a competency framework for organizing STEAM education activities tailored to preschool education students. The article ultimately contributes to supporting schools in establishing and improving training programs, aiming at training preschool teachers capable of effectively organizing STEAM education activities, in response to the increasingly demanding requirements of the education sector.
INSTRUCTION BASED ON THE VARK LEARNING STYLES OF PRIMARY STUDENTS IN SCIENCE
Authors: Viet Quynh Pham
Published: December 2024

VARK is a learning style model developed by Neil Fleming in the 1980s. VARK represents the four main learning styles: Visual, Aural, Read/Write, and Kinesthetic. The VARK model provides a deep understanding of different learning preferences, consequently supporting both learners and educators within the teaching-learning process. This contributes to the goal of developing student competencies in the Science subject, as per the 2018 general education curriculum. This research is based on the theoretical analysis of learning styles, and the science curriculum, to propose a science teaching and learning process that addresses the various learning styles of elementary school students, with specific illustrative examples. At the same time, the research conducts pedagogical experiments to initially evaluate the effectiveness and feasibility of the proposed process. The flexible integration of VARK-based learning activities will create a diverse, engaging, and stimulating learning environment in the teaching and learning of the Science subject, which will encourage active student participation and contribute to the enhancement of scientific competencies for primary school students.
RESEARCHING THE EXPERIENCE OF SOME COUNTRIES ON SUPPORTING MEASURES FOR STUDENTS IN SELECTING CAREER-ORIENTED SUBJECTS IN IMPLEMENTING THE GENERAL EDUCATION CURRICULUM
Authors: Thi Hong Van Ho , Thi Thuy Hanh Doan , Thanh Ha Vo , Trong Duc Nguyen , Thi Thanh Nguyen , Thi Chi Nguyen , Trung Dung Le , Ngoc Hoan Le
Published: December 2024

Career orientation for students plays an important role and is the basis for students to choose appropriate elective subjects at the high school level, according to the General Education Curriculum 2018. The purpose of this research is to examine the experience of some countries in supporting students in choosing career-oriented subjects. This study investigated general education curriculum and solutions to support students in choosing subjects in several countries, such as the US, Germany, Netherlands, Norway, Australia, Singapore, and Japan. The results of this study include: 1) analyzing career-oriented goals in the general education curriculum and supporting measures for students in career-oriented subject selection in some countries around the world; 2) proposing some lessons learned for Vietnam in supporting students in choosing career-oriented subjects in implementing the General Education Curriculum 2018.
Nurses' Perceptions of Pediatric Palliative Care with Cancer In Hospitals In Bandung City
Authors: Abas Latifa Hidayani , Mediani Henny Suzana , Agustina Hana Rizmadewi
Published: December 2024

Background: Pediatric palliative care (PPC) has seen significant progress in recent decades. Despite the improvements in care, nurses still feel anxious, fearful, and hesitant in providing PPC. More research efforts are needed to identify and explore nurses' perceptions of PPC in children with cancer.Objective: The aim of this study was to explore nurses' perceptions of palliative care in children with cancer.Methods: This study was a descriptive qualitative study. Participants were selected using purposive sampling. They were eleven nurses from Kenanga Room 2 of Hasan Sadikin Hospital, Bandung. Data were collected using semi-structured interviews and analyzed using thematic analysis method. The research was conducted from March to April 2023.Results: This study identified four main themes and nineteen subthemes. The themes in this study are (1) Nurses' understanding of PPC, (2) Barriers to the implementation of PPC in children with cancer (3) Nurses' needs and expectations for PPC improvement, and (4) Roles and responsibilities of nurses in PPC.Conclusions: This study described the clinical reality of nurses providing PPC to children with cancer in one of the hospitals in Indonesia. The findings suggested that addressing these challenges could lead to significant improvements in pediatric palliative care practices in the hospital setting.
Satisfacción con el cuidado de enfermería desde la perspectiva del paciente hospitalizado con enfermedad renal crónica en un hospital de Honduras durante 2022
Authors: Juárez-León Tesla Gioconda
Published: December 2024

Introducción: La satisfacción permite evaluar la calidad de la atención en los servicios de salud y se aplica al cuidado que el personal de enfermería brinda a pacientes con condiciones médicas permanentes, como la enfermedad renal crónica, que demanda un cuidado integral y humanizado. No obstante, existe un vacío en la literatura regional en relación con la medida de satisfacción en los pacientes. Objetivo: Determinar la satisfacción con el cuidado de enfermería desde la perspectiva del paciente hospitalizado con enfermedad renal crónica en el Hospital General Atlántida, Honduras, durante abril y julio de 2022. Métodos: Se realizó un estudio observacional descriptivo de tipo transversal en el Hospital General Atlántida, entre abril y julio de 2022; la selección de los pacientes fue por conveniencia, mediante entrevistas directas. La recolección de datos se realizó a través de un instrumento conformado por variables sociodemográficas y dimensiones de la satisfacción (estructura, proceso, resultado). Resultados: La población estudio estuvo conformada por 30 pacientes, con edad promedio de 64,3 , los cuales el 66,7 % eran mujeres; las dimensiones antes mencionadas fueron calificadas en un rango de regular a bueno, con medias de 20,77, 8,80 y 7,73 respectivamente. El puntaje promedio para las tres dimensiones también se calificó en el rango de regular a bueno con 47,30. Conclusión: El 53,3 % de los pacientes con enfermedad renal crónica se mostró satisfecho con los cuidados recibidos, aunque solo el 46,7 % los recomendarían. Asimismo, implementar intervenciones dirigidas al personal de enfermería permitiría mejorar la calidad de los cuidados brindados.
PERCEPÇÃO DE MELHORA DO SOFRIMENTO MENTAL COM O USO DE PRÁTICAS INTEGRATIVAS E COMPLEMENTARES
Authors: Hences Luiza , Prado Kantorski Luciane , De Oliveira Couto Maria Laura
Published: December 2024

Objetivo: conhecer a percepção de melhora do estado de sofrimento mental dos usuários dos serviços públicos de saúde após a utilização de Práticas Integrativas e Complementares. Método: estudo descritivo de abordagem qualitativa realizado com treze usuários de três serviços públicos de saúde, de setembro a outubro de 2019. Para a coleta de dados foi utilizado um roteiro semiestruturado. As entrevistas foram gravadas, transcritas e categorizadas para discussão temática. Resultados: foram entrevistados nove mulheres e quatro homens, todos com idade entre 20 e 61 anos. Sete dos entrevistados tinham depressão e ansiedade associados. Os participantes relataram melhora nos sinais e sintomas de depressão e ansiedade, bem como sensação de tranquilidade após utilização de uma PIC. Conclusões: a partir da utilização de práticas integrativas e complementares, os usuários revelaram melhora psíquica, com percepção da manutenção do equilíbrio emocional e bem-estar. Dessa forma, destaca-se a importância dessas práticas para redução do sofrimento mental.
DISCURSO DE ENFERMEIROS SOBRE APLICAÇÃO DO PROTOCOLO DE MANCHESTER NA URGÊNCIA E EMERGÊNCIA HOSPITALAR
Authors: Matias de Oliveira Flávia Maria , Santiago Lemos de Beltrão Izabel Cristina , De Siqueira Coelho Lisboa Kenya Waleria , Alves dos Santos Gadelha Naftale , Rodrigues Pinheiro Woneska , Lopes Lucas Thays
Published: December 2024

Objetivo: Analisar os discursos dos enfermeiros de um serviço de urgência e emergência hospitalar, referente à utilização do Protocolo de Manchester. Método: Trata-se de uma pesquisa de campo, com abordagem mista e natureza descritiva, realizada com enfermeiros atuantes na classificação de risco. A coleta de dados ocorreu através de um formulário socioeconômico e roteiro de entrevista semiestruturada, utilizando-se o Discurso do Sujeito Coletivo para organização e análise dos dados. Resultados: Identificou-se 14 ideias centrais nas expressões dos 8 enfermeiros entrevistados. São potencialidades do Sistema de Triagem de Manchester: a otimização do tempo na classificação de risco e a organização do fluxo de acordo com a prioridade clínica, impactando na espera do usuário que, geralmente, acolhe bem o protocolo. Conclusão: Percebeu-se o atendimento de usuários com queixas variadas ou não correspondentes ao perfil da instituição; falha na rede de atenção à saúde e administração de múltiplos protocolos de classificação.
Descritores: Classificação de Risco; Triagem; Enfermagem em Emergência.
Book Review: Ngũgĩ wa Thiongʼo, Decolonising the Mind: The Politics of Language in African Literature
Authors: Singleton Aled
Published: December 2024

In this book review I consider Ngũgĩ wa Thiong'o’s work Decolonising the Mind, published in 1986. A particular focus for my account is to acknowledge the deeper impact of suppressing Indigenous languages, and particularly the results of holding back written forms. Looking to future applications within spatial theory, I consider how Ngũgĩ describes the role of theatre to activate memory and reacquaint people with narratives and cultures apprehended by colonisation. I start with a short biography of Ngũgĩ and the context of the book.
Aprendizaje reforzado en pair-trading Aplicación para una estrategia pair-trading
Authors: Quintero González Cristian
Published: December 2024

Este estudio explora las implicaciones de la implementación de técnicas de apren­dizaje reforzado para el trading de acciones parte del índice S&P 500 al 15 de octubre de 2022, bajo una estrategia de pair-trading. A través de un proceso de selección de pares de acciones se investiga si modelos de aprendizaje reforzado ofrecen una ventaja frente estrategias más simples. Los resultados indicaron sorpresivamente que modelos entrenados con entornos sencillos como el que no permite posiciones en corto, producen una mayor y constante rentabilidad, si se compara con los agentes entrenados en entornos con mayor complejidad lógica como lo son el de proporción del saldo disponible para entrar en posiciones según el conjunto de acciones y β-balanceado. Adicionalmente se observó que un incremento en el número de pasos por episodio, que generalmente lleva a con­sumir un mayor tiempo de entrenamiento para el hardware usado, no es garantía de mejorar considerablemente la varianza de la distribución de rentabilidades potenciales en los datos de trading, como tampoco es una variable que permita mejorar significativamente la media del retorno u otros indicadores, lo que se evidencia también en los valores value loss y policy loss, los cuales se tornaban explosivos y más volátiles luego de un valor de episodios determinado.
Eufemizmy i hiperbole jako środki perswazyjno-manipulacyjne
Authors: Kujawiak Aleksandra
Published: December 2024

Głównym celem rozprawy jest analiza eufemizmów i hiperboli jako środków perswazyjno-manipulacyjnych w dwu typach dyskursu prasowego: liberalnym (reprezentowanym przez tygodniki „Newsweek” i „Politykę”) oraz konserwatywnym (reprezentowanym przez pisma „Do Rzeczy” i „Sieci”). Ekscerpcja środków językowych z pism o odmiennym profilu światopoglądowym miała umożliwić analizę obu środków jako narzędzi wywierania wpływu na odbiorcę. Zgromadzono około 700 przykładów, które pochodzą z losowo wybranych tekstów publikowanych w wybranych tygodnikach opinii w latach 2017–2020. Szczegółowe pytania badawcze, na jakie miała odpowiedzieć rozprawa, dotyczyły następujących kwestii: pól tematycznych i semantycznych eufemizmów i hiperboli; form, jakie przybiera eufemizacja i hiperbolizacja w dyskursie prasowym; funkcji tekstowych pełnionych eufemizmy i hiperbole oraz ich cech wspólnych i różnicujących. Rozprawa składa się z dwóch zasadniczych części: teoretycznej i analitycznej. Pierwsza z nich obejmuje 7 rozdziałów, w których omówione zostały: podstawowe zagadnienia i terminy związane z tematem pracy, stan badań dotyczący eufemizmów i hiperboli, procedura badawcza, metody badawcze (metoda analizy tematycznej wg B. Batko-Tokarz, analiza formalna A. Dąbrowskiej, metoda analizy pól semantycznych opisana przez U. Topczewską) oraz charakterystyka tygodników opinii. Część analityczna składa się z trzech zasadniczych rozdziałów. W każdym z nich zastosowano inną metodę badawczą służącą do przeprowadzenia analizy badanych środków z innej perspektywy badawczej (tematycznej, formalnej i funkcjonalnej) w myśl założeń wielopoziomowej lingwistycznej analizy dyskursu I. Warnkego i J. Spitzmüllera. Aneks do pracy stanowi słownik tematyczny eufemizmów i hiperboli wyekscerpowanych z tygodników opinii.
Decreasing Primary Cesarean Births by Increasing Effective Maternal Care at a Community-Based Hospital
Authors: Reagan Teresa L. , Myers Sybilla
Published: December 2024

Background:Nulliparous cesarean birth rates have plateaued at 25% since 2019. Cesarean births contribute to 37% of severe maternal morbidity and can increase costs by longer lengths of stay, increased admissions to the neonatal intensive care unit, further postoperative complications, and an increased likelihood of subsequent cesarean births.Local Problem:At this community hospital, the rate of cesarean births for nulliparous, term, singleton, and vertex (NTSV) pregnancies rose almost 3% in 2022. This quality improvement (QI) project was aimed to decrease NTSV cesarean births by increasing effective maternal care by 80% at a community-based hospital.Methods:The Plan–Do–Study–Act model was applied for this rapid-cycle QI over 8 weeks with four 2-week cycles. The data were collected every other day, reviewed biweekly to inform data collection, and analyzed for the next test of change.Interventions:A patient screening tool was used to identify nulliparous mothers, and a patient effective care checklist tool was used to improve effective maternal care.Results:Staff utilization overall resulted in 81% screening of 215 mothers and identified 116 nulliparous mothers. The average effective care score was 84%. The checklist improved effective maternal care to 84% and reduced the NTSV cesarean births by 7%.Conclusion:Identifying nulliparous mothers on admission and then providing effective care to women in labor has the potential to decrease the NTSV cesarean birth rate. It can be utilized by every laboring mother, furthering the reduction of cesarean births.
Les plantations forestières en Afrique tropicale sèche - Techniques et espèces à utiliser. Les espèces essayées en zones sèches d'Afrique (de Eucalyptus à Ziziphus mucronata)
Authors: Delwaulle J.C.
Published: December 2024

Ce dernier volet présente les résultats obtenus avec des espèces dont les noms scientifiques, classés par ordre alphabétique, vont d'Eucalyptus à Ziziphus mucronata.Les conclusions auxquelles l'auteur est parvenu sont indiquées :- Une bonne plantation ne peut pas être réalisée n'importe où.- De nombreuses techniques de plantation ont été développées.- Le choix des espèces de reboisement est limité.- Des recherches sont encore nécessaires et certaines techniques doivent être affinées.
Application de la méthode des variables régionalisées à deux forêts du Gabon
Authors: Narboni Philippe
Published: December 2024

La méthode des variables régionalisées a été utilisée pour l'analyse structurelle et l'estimation locale des données forestières, pour l'inventaire des ressources papetières et pour le dénombrement exhaustif des bois au Gabon.Les résultats obtenus, en particulier dans le cas de l'Okoumé, révèlent l'existence de corrélations spatiales. La prise en compte de cette structure apporte un gain appréciable en précision et en qualité d'estimation par rapport à une méthode traditionnelle. Elle permet une véritable cartographie des ressources forestières.
Kinetics Extraction of Arabica Coffee Bean (Coffea Arabica)
Authors: Lailatul Fatma  , Nabilah Lu’aili Fauziah  , Zuhriah Mumtazah  , Helda Wika Amini  , Boy Arief Fachri
Published: December 2024

Coffee beans are the seeds of the coffee plant and a source of coffee beverages. Arabica coffee beans contain oil which has many benefits. The process of extracting oil (solute) in coffee can be done through solvent extraction (leaching). The coffee bean oil extraction process uses n-hexane as a solvent because it can dissolve compounds that have the same properties. The purpose of this research was to study the extraction of essential oil from Arabica coffee beans and to determine the kinetic model of extraction of essential oil from Arabica coffee beans by leaching. The process of separating coffee oil and solvent using thermogravimetric analysis with a temperature of 80℃ until the sample mass is constant. The variables used were temperature and time. The extraction time is 2 hours with retrieval time every 10 minutes. The temperature used is 30°, 40°, and 50℃ with a ratio of material and solvent 1:10. The results showed that the kinetics of arabica coffee extraction followed the second-order extraction kinetics model. The second-order kinetic parameter values of arabica coffee essential oil extraction namely extraction capacity (Cs) at 30°, 40°, and 50℃ were 5.45836, 5,46, and 5.46001 g L-1, respectively, the rate of the initial extraction (h) was 0,00762718, 0,00756716, and 0,0104452 gL-1minute-1, the extraction rate constant (k) was 0,000256, 0,000254, and 0,00035 g-1L-1minute-1, and determination values of 0,9965, 0,9967 and 0,9983.
The Effect of Time, Ph and Starter Concentration on Bioethanol Content in the Tobacco Stem Fermentation Process
Authors: Putri Ayu Salsabila  , Della Ainurrohma  , Indah Wahyuningtyas
Published: December 2024

The depletion of fossil fuels has now occurred in various parts of the world. Meanwhile, the demand for fuel energy continues to increase. This condition encourages researchers to look for alternative fuels with high availability of raw materials. Bioethanol is an environmentally friendly renewable energy with biomass production raw materials, it can be an alternative solution to replace fuel oil. One of the biomass that has the potential to be used as a raw material for bioethanol production is tobacco. Tobacco stems have high cellulose and hemicellulose content so that they can be used in bioethanol production. This research method uses base pretreatment and base hydrolyzate, then fermentation and distillation processes are carried out. The results of tobacco stem bioethanol were analyzed using the Response Surface Methodology (RSM) approach, Central Composite Design (CCD) model. During the fermentation process, three independent variables were used, namely the fermentation time of 72-168 hours, pH 4-5, and starter concentration of 0.1% - 0.3%. The results of the Analysis of Variance (ANOVA) of ethanol content showed that the significant variables were the fermentation time and starter concentration. The results of the CCD analysis were obtained at optimum time conditions of 120 hours, pH 4.5 and starter concentration of 0.2% with a bioethanol content of 23.007%.
Water Maceration of Black Mahlab Effectively Inhibits the Growth of Staphylococcus aureus Associated with Skin Infections
Authors: Oshi Murtada Ahmed Mohmmed
Published: December 2024

Background: With the rising risk of antibiotic resistance, our ability to combat Staphylococcus aureus (S. aureus) in skin and soft tissue infections (SSTIs) is being compromised. Purpose: This study aimed to determine the activity of several aqueous extracts of black mahlab seeds (maceration, infusion, and decoction) against S. aureus-associated SSTIs. Methods: We employed the disc diffusion Kirby-Bauer method to evaluate the anti-staphylococcal activity of the extracts. Furthermore, we used various extract concentrations to calculate each extract's minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) against S. aureus. Result: The results revealed enhanced anti-staphylococcal activity, with inhibition zones measuring 11.5, 22.5, and 26.5 mm at concentrations of 25, 50, and 100 mg/ml, respectively. These effects were similar to ampicillin against S. aureus and significantly higher (p  0.05) than gentamicin. The extracts showed antibacterial activity with MICs and MBCs ranging from 12.5 to 25 mg/ml. Conclusion: Overall, compared to the clinically prescribed antibiotics, ampicillin, and gentamicin, black mahlab seed extract obtained by water maceration exhibits increased anti-staphylococcal activity associated with SSTIs.
SECTORAL FINANCING CONCENTRATION AND SHARIA RURAL BANKS’ PROFITABILITY
Authors: Widarjono Agus , Mifrahi Mustika
Published: December 2024

Introduction: Sharia rural banks (SRBs) in Indonesia face high non-performing financing (NPF). The high NPF likely causes a decrease in the profitability of SRBs. One strategy to overcome high financing risk is selecting the appropriate financing strategy either sectoral financing diversification or concentration. This study explores the impact of sectoral financing concentration along with some control variables on the profitability of Sharia rural banks in Indonesia using aggregate data of SRBs from 2010:M1 to 2023:M12
Methods: Our study employs the quantitative method utilizing the Autoregressive Distributed Lag (ARDL). Returns on Assets (ROA) are utilized to measure profitability and Sectoral financing concentration is measured by the Herfindahl-Hirschman index (HHI). Some control variables are assets, capital adequacy ratio (CAR), financing (FIN), cost-income ratio (CIR), NPF, consumer price index (CPI), and COVID.
Results: The results show cointegration, indicating the long-run relationship among the variables being studied. The findings signify that sectoral financing concentration fortifies Sharia rural banks' profitability. Also, the size and equity enhance profitability. The results also highlight that low inflation increases profitability and COVID-19 lowers profitability.
Conclusion and suggestion: Our results suggest that Sharia rural banks should have competent experts in specific economic sectors such as trade, restaurants, and hotels, which generate more profit due to comparative advantage.
Assessment of a methodology to evaluate constructive systems for industrialization: the case of dwellings in Spain.
Authors: Sánchez Olga , Barbero-Barrera María del Mar
Published: December 2024

Building monitoring systems deliver large volumes of information and advanced data analysis tools are available. A fault detection and diagnosis (FDD) problem in building energy systems can also be regarded as a pure machine learning problem. The aim of this work is to promote FDD with machine learning applications in building environment. As a contribution, in this work raw time data series, obtained from a SCADA, are processed for further pattern construction of a building thermal facility. The thermal facility supplies the DHW, and heating demands of a residential building, consisting of 26 social dwelling units and located at Durango (northern Spain). Data recorded every 24 hours in cumulative values is included in the R software for computing statistical graphs. For DHW and heating consumption meter values, 229 valid data points are obtained, and the daily consumption ranges are between 1.94 - 5.90 m3 and 0 - 547.63 kWh respectively.
Impact of BRAF and MEK Inhibitors on Gingival Hyperplasia in Melanoma Patients
Authors: Veljović Tanja , Đurić Milanko , Gušić Ivana , Vučković Nada , Ramic Bojana , Mirnić Jelena
Published: December 2024

Although BRAF inhibitors (such as vemurafenib) produce a marked response in patients with advanced melanoma with a BRAF V600 mutation, they eventually develop resistance to this treatment. To address this issue, vemurafenib is increasingly combined with the MEK inhibitor cobimetinib, leading to improved response rates and enhanced survival. However, this treatment modality is associated with numerous side effects. We present a case of gingival hyperplasia in a patient treated with vemurafenib, along with the strategy adopted for the management of this condition, and the impact of subsequent cobimetinib administration on its severity. This case underscores the importance of recognizing and adequately addressing this complication, as its adverse effect on patient’s quality of life can potentially compromise treatment protocol adherence.
Innovative Carwash Wastewater Treatment and Reuse Through Nature-Based Solutions
Authors: Torrens Antonina , Sepúlveda-Ruiz Paola , Aulinas Montserrat , Folch Paola
Published: December 2024

Vehicle washing facilities (VWFs) consume substantial tap water and produce wastewater with harmful compounds. This study examines Nature-based Solutions (NbS) for treating and recycling vehicle wash wastewater. Conducted at a VWF in Girona, Spain, the project tested three pilot systems: Vertical Flow Treatment Wetland (VFTW), Horizontal Flow Treatment Wetland (HFTW), and Infiltration-Percolation (IP) filter. Over two years, 32 quality parameters, including physicochemical and microbiological indicators, were monitored. VFTW and IP systems were the most effective, reducing turbidity below 5 NTU, COD to under 20 mg/L, and E. coli below 10 CFU/100 mL, meeting Spanish reuse standards. Pre-treatment was critical for managing oils, fats, and hydrocarbons, preventing clogging in the HFTW and IP systems. A final chlorination step ensured residual disinfectant, particularly for controlling Legionella, allowing the treated water to be safely used in the pre-wash and initial wash stages. The systems achieved up to 60% water reuse, reducing the need for potable water, minimizing pollutants, and cutting operational costs, contributing to a more sustainable approach in vehicle washing operation.
Identification of Leaf Stripe Resistance Genes in Hulless Barley Landrace Teliteqingke from Qinghai-Tibet Plateau
Authors: Tan Zemin , Zhang Sai , Qu Yunfeng , Kang Shenghua , Fang Shiyu , Hou Lu
Published: December 2024

Leaf stripe disease, a seed-borne fungal disease caused by Pyrenophora graminea, poses a significant threat to hulless barley (Hordeum vulgare var. nudum) production on the Qinghai-Tibet Plateau. This study aimed to identify genetic factors conferring resistance to leaf stripe by analyzing an F3 population derived from a cross between the resistant landrace Teliteqingke and the susceptible landrace Dulihuang. Genetic analysis revealed that resistance in Teliteqingke was governed by two dominant genes. Using bulked segregant analysis combined with SNP array (BSA-SNP) and RNA-seq, we identified two candidate regions on chromosomes 3H and 7H. Further analysis focused on chromosome 3H, which revealed a candidate genomic region containing seven potential disease-resistance genes. Among these, RT-qPCR experiments demonstrated that HORVU.MOREX.r3.3HG0232110.1 (encoding a RING/U-box superfamily protein) and HORVU.MOREX.r3.3HG0232410.1 (encoding a bZIP transcription factor) showed significant expression induction following inoculation with P. graminea. These genes can be candidate genes involved in resistance mechanism against leaf stripe in Teliteqingke. These results provide a foundation for functional validation of these genes and offer valuable insights for breeding disease-resistant hulless barley.
Monetary Policy: Tools, Impacts, and the Path Forward
Authors: Jayachandran Prabanjan , Jethlia Vedaansh , Yadav Avi
Published: December 2024

In the wake of numerous banking panics plaguing the nation’s economic stability, a strengthened structure was implemented to replace the country’s largely fragile and fragmented banking system. This came in the form of the United States Federal Reserve, an independent body tasked with ensuring economic stability. Since its implementation by Congress in 1913, the Federal Reserve has served as the United States’ primary decentralized centralized banking system. What began as a small and divisive banking system, has today become the largest and most powerful economic institution, not only in the U.S., but the world. The purpose of this paper is to provide data-driven, objective insights into the various tools employed by the Fed, their effectiveness, limitations, criticisms, and an outlook for the future of the central banking system in a growing digital world.
Advances in the study of Empoasca onukii Matsuda (Hemiptera: Cicadellidae) Matsuda
Authors: Kanu Unisa Conteh , Wang Zhaohong , Qiu Chenshi , Wen Qiaojun , Li Xueyan , Qiu Dongliang , Gan Yinwei , Mao Runqian
Published: December 2024

This review explores the evolving role of the tea green leafhopper, Empoasca onukii, in the tea industry, transitioning from a recognized pest to a significant enhancer of tea quality. Recent research highlights how its feeding behavior stimulates the production of desirable secondary metabolites, thereby improving the flavor profiles and market value of premium teas, particularly varieties like Taiwan's "Oriental Beauty." As consumer demand for unique and artisanal teas rises, the economic benefits associated with E. onukii are becoming increasingly evident, prompting farmers to adopt sustainable agricultural practices that often involve reduced pesticide use. Furthermore, the dynamic interplay between climatic factors, E. onukii population dynamics, and tea cultivation practices necessitates integrated pest management strategies that balance the beneficial and detrimental impacts of this leafhopper. Understanding these complexities not only fosters sustainable production methods but also opens niche markets, benefiting local economies. Ultimately, this shift in perspective positions Empoasca onukii as a vital asset in the cultivation of high-quality tea, promoting both economic viability and environmental sustainability in the tea industry.
Redirection of Care for Neonates with Hypoxic-Ischemic Encephalopathy Receiving Therapeutic Hypothermia
Authors: Gubler Deborah , Wenger Adriana , Boos Vinzenz , Liamlahi Rabia , Hagmann Cornelia , Brotschi Barbara , Grass Beate
Published: December 2024

Background/Objectives: Hypoxic-ischemic encephalopathy (HIE) in (near)term neonates accounts for neonatal mortality and unfavorable neurodevelopmental outcome in survivors, despite therapeutic hypothermia (TH) for neuroprotection. The circumstances of death in neonates with HIE and involvement of neonatal palliative care (NPC) specialists warrant further evaluation. Methods: Retrospective multicenter cohort study including neonates ≥ 35 weeks gestational age with moderate to severe HIE receiving TH, registered in the Swiss National Asphyxia and Cooling Register between 2011 and 2021. Neurodevelopmental follow-up at 18-24 months in survivors was assessed. The groups of survivors and deaths were compared regarding perinatal demographic and HIE data. Prognostic factors leading to redirection of care (ROC) were depicted. Results: 137 neonates were included, 23 (16.8%) deaths and 114 (83.2%) survivors. All but one death (95.7%) occurred after ROC with death on median 3.5 (2-6) days of life. Severe encephalopathy indicated by Sarnat score 3 on admission and seizures were more frequent, and blood lactate values were higher on postnatal days 1 to 4 in neonates who died. Lactate in worst blood gas analysis (unit aOR 1.25, 95% CI 1.02-1.54, p=0.0352) was the only variable independently associated with ROC. NPC specialists were involved in one case. Of 114 survivors, 88 (77.2%) had neurodevelopmental assessments, and 21 (23.9%) of those had unfavorable outcome (moderate to severe disability). Conclusions: Death in neonates with moderate to severe HIE receiving TH almost exclusively occurred after ROC. Parents thus had to take critical decisions and accompany their neonate at end-of-life within the first week of life. To ensure continuity of care for the family, also beyond the death of the neonate, involvement of NPC specialists is encouraged in ROC.
LOCKED: A Dataset of Sociodemographic, Economic, Health and Living Features to Assess Mental Health Impact of the Spanish Lockdown during COVID-19
Authors: Mellor-Marsá Blanca , Guitián Alfredo , García-Tejedor Álvaro J. , Nogales Alberto
Published: December 2024

The COVID-19 pandemic, which began in late 2019 in Wuhan, China, quickly escalated into a global crisis, affecting nearly every aspect of life. Governments worldwide implemented stringent public health measures to control its spread, including quarantines, social distancing, and lockdowns. In Spain, where the first cases emerged in January 2020, a nationwide lockdown was enforced on March 14 after infections surpassed 5,000. While these interventions were crucial for public health, they also introduced profound societal challenges, particularly for vulnerable populations. This study presents a dataset combining psychological assessments of nine mental health conditions with sociodemographic, economic, living, and health variables, aiming to identify the key factors influencing mental health outcomes during the lockdown. By analyzing this data, the research seeks to shed light on the broader psychological effects of the pandemic and the factors that may exacerbate or mitigate these impacts. The dataset performed well with different machine learning models with values over 80%. It is publicly available at https://zenodo.org/uploads/14203988.
Microfluidic Gel Chromatography-Enabled In-Situ Raman Spectroscopy for Selective Electronic-Type Separation and Analysis of Single-Walled Carbon Nanotubes
Authors: Beom Byeongji , Jung Seung-Chan , Jang Wonjun , Won Jong-Keon , Jeong Jihoon , Choi Yu-Jeong , Moon Man-Ki , Han Jae-Hee
Published: December 2024

Single-walled carbon nanotubes (SWNTs) possess unique electronic properties—either metallic or semiconducting—defined by their chirality, making their selective separation a cornerstone for advancing nanotechnology applications. While conventional gel chromatography has proven effective for large-scale separation, the demand for microscale precision to uncover nanoscale interaction mechanisms and optimize separation strategies remains unmet. In this study, we report the development of a polydimethylsiloxane (PDMS)-based microfluidic platform integrating gel chromatography with in-situ Raman spectroscopy to achieve high-resolution electronic-type separation of SWNTs. By systematically isolating metallic- and semiconducting-enriched fractions (M1-M3, S1-S3), our approach leverages real-time Raman spectroscopy to reveal dynamic shifts in G-band characteristics and G⁻/G⁺ intensity ratios, providing quantitative insights into separation efficiency and purity. The platform’s novel integration of rate constant analysis and SDS concentration normalization highlights the inherent elution kinetics of SWNTs, with metallic SWNTs exhibiting accelerated separation dynamics compared to their semiconducting counterparts. This advancement not only enhances the resolution of electronic-type differentiation but also underscores the critical role of dispersant concentration in fine-tuning separation outcomes. The results establish this PDMS microchannel system as a versatile and scalable solution, bridging the gap between industrial-scale separations and microscale precision, paving the way for cutting-edge nanomaterial purification technologies.
High-Intensity Focused Ultrasound Ablation for Primary or Salvage Prostate Cancer Therapy: Initial Outcomes in the Veteran Healthcare Setting
Authors: Patel Sagar , Antar Ali , Alrabaa Aly , Saffati Gal , Fleming Broderick , Srikishen Neel , Slawin Jeremy , Taylor Jennifer , Jones Jeffrey
Published: December 2024

High Intensity Focus Ultrasound (HIFU) provides comparable oncologic, erectile, and urinary outcomes to standard of care options for localized prostate cancer. This study reports the largest United States series of HIFU in veterans for both primary and salvage therapy. We retrospectively analyzed outcomes of 43 veterans treated at the Michael E. DeBakey Veterans Affairs Medical Center from 2018 to 2022. Primary endpoints included prostate specific antigen (PSA) reduction, oncologic control, and local recurrence. Secondary endpoints included 30-day complications, Sexual Health Inventory for Men (SHIM), and American Urological Association Symptom Score (AUASS). Among patients, 31 (72.1%) received primary treatment and 12 (27.9%) received salvage therapy, with a median follow-up of 23 and 25 months, respectively. Median PSA nadir was 0.16 for primary and 0.12 for salvage groups, with PSA reduction stable over 30 months. Local recur-rence occurred in 16.1% of primary and 16.6% of salvage patients. SHIM scores and AUASS were not statistically different before and after HIFU therapy. Short-term results suggest HIFU is a safe and effective treatment option with excellent potency and preserved urinary function, as well as reasonably adequate immediate oncologic control for primary and salvage therapy for localized prostate cancer in Veterans.
Catalytic Methane Decomposition for the Simultaneous Production of Hydrogen and Low Reactivity Biocarbon for the Metallurgic Industry
Authors: Khalil Roger Antoine , Jayakumari Sethulakshmy , Dalaker Halvor , Wang Liang , Tetlie Pål , Skreiberg Øyvind
Published: December 2024

To reach agreed-on climate goals, it is necessary to develop new energy carriers and industrial materials that are carbon neutral. To combat global warming and keep Earth’s temperature below a 1.5 °C increase, some of these solutions need to be carbon negative. This study fulfills this criterion by producing clean hydrogen, and biocarbon, suitable for the metallurgic industry, through the thermal decomposition of methane using biocarbon as a catalyst. Five different biomass samples were used to prepare biocarbons, at a pyrolysis temperature of 1000 °C and a holding time of 90 minutes. When methane was cracked at 1100 °C and a holding time of 90 minutes, the highest hydrogen production was 105 mol/kg biocarbon, using birch bark. The lowest hydrogen yield, of 68 mol/kg biocarbon, was achieved with steam explosion pellets. All biocarbons showed substantial carbon deposition from cracked methane on the surface, with the highest deposition on birch bark and spruce wood biocarbon, of 42 % relative to the biocarbon start weight. The carbon deposition increased with decomposition temperature, methane-share in the purge gas and holding time. The steam explosion pellets, after deactivation, had a CO2 reactivity that is comparable to coke, a reducing agent that is commonly used in manganese producing industry.
Melanoma Growth Restrainment Depends on CD1 Molecules in C57BL/6 Mice Treated with Imiquimod
Authors: Bonfim Maiara , Silva Amanda CO , Mengel Jose , Cardillo Fabiola
Published: December 2024

Imiquimod (IMIQ), a TLR7 agonist, enhances the anti-tumor response rapidly and persistently. In this study, we aimed to assess the effects of IMIQ in an experimental melanoma model to determine whether it is useful for restraining tumor growth and prolonging animal survival following IMIQ treatment in wild-type C57Bl/6 (WT) and C57Bl/6 CD1-knockout mice (CD1-/-). Mice were treated with IMIQ following subcutaneous injection of tumor cells into the pinna of the ears. We analyzed tumor size, survival, and splenic cell phenotypes. In addition, intracellular cytokines were evaluated after stimulation with anti-CD3. IMIQ treatment effectively restrained early tumor growth and increased survival only in WT. Antigen-presenting cell (APC) frequencies were higher in WT animals than in all CD1-/- animals regardless of IMIQ treatment. Higher numbers of NK+perforin+ splenic cells were found in WT mice, and higher numbers of IFN-gamma-producing CD4+ T cells were found in anti-CD3 stimulated splenic cells when IMIQ-treated WT mice were compared to the CD1-/- animals. Moreover, more splenic CD8+ T cells TNF-alpha+ producers were detected in WT compared to CD1-/- animals in unstimulated splenic cells. WT mice were protected by IMIQ from early mortality, presenting slowed melanoma development. The increased number of APCs in response to IMIQ was likely to be involved in the imiquimod in vivo effect and depended on the CD1 molecule. IMIQ induces higher numbers of splenic IFN-gamma+CD4+ T cells and TNF-alpha + CD8+ T cells, NK cells, and NKT cells expressing perforin.
Effect of Filler Density on the Mechanical Properties of Natural PEEK 450 Processed by FDM
Authors: Vázquez-Silva Efrén , Pintado-Pintado Jonnathan Andrés , Moncayo-Matute Freddy Patricio , Torres-Jara Paúl Bolívar , Moya-Loaiza Diana Patricia
Published: December 2024

In the present investigation, the mechanical properties of natural PEEK 450 processed by 1 additive manufacturing and applying fused deposition modeling (FDM) are investigated. Mechanical 2 characterization was performed through destructive testing, following ASTM D638-14, ASTM D695- 3 15 and ASTM D790-10 standards. Specimens were designed in CAD software and printed with 4 controlled infill densities of 40%, 70% and 100%, using a rectilinear pattern. The results showed that 5 an increase in infill density improves mechanical strength and stiffness, but reduces ductility and 6 energy absorption capacity. These findings offer crucial information for optimizing infill density in 7 the manufacturing of high-strength components for industrial and biomedical applications. As a 8 result, practical guidelines are provided for the design of medical devices, such as implants, achieving 9 an appropriate balance between mechanical performance and material efficiency.