bluuebunny/crossref_metadata_2025 huggingface dataset:
SMART SURVEILLANCE SYSTEM WITH FACE RECOGNITION USING OPEN-SOURCE COMPUTER VISION
Authors:   Godavari Institute of Engineering and Technology (A), Rajahmundry, India, Devarapalli Venkatesh , Ashok Chakravarthi Patcha ,   Godavari Institute of Engineering and Technology (A), Rajahmundry, India, Samuel Nissi Nandiki ,   Godavari Institute of Engineering and Technology (A), Rajahmundry, India, Reddy Mallu Udhay Kumar ,   Lovely Professional University, Phagwara, India.
Published: June 2022

The current project is primarily concerned with ensuring a secure environment and also free from the hold-ups that occur in your surroundings. This automated surveillance system detects intruders using various devices with software. The major software employed in the current work is Open CV (open-source computer vision). The primary method utilized in the present work is if any person appears in front of the pi camera. It will switch on by observing for probable matches that have previously been stored in our database. If the module finds a match, then it continues to record until an intruder comes. If the face is not recognized then the unknown person’s face will be captured and a snapshot will be sent to the user’s email. The device is developed using Raspberry Pi with a 1.4 GHz quad-core processor, a raspberry pi camera with 12MP high-resolution, and a Wireless dongle to communicate with users’ email. For motion detection, most existing systems employ a Passive Infrared (PIR) motion sensor. Despite its inexpensive cost, such a system has some demerits. For example, as a result of an exceptional situation, such as rapid heating induced by sun exposure, false alarms may be triggered. To increase the efficiency of motion detection, a smart surveillance system is constructed using Open CV on a Raspberry Pi 3 Model B. According to the findings, the built smart surveillance security system using Open CV has a detection rate of 96%, whereas the PIR motion sensorbased security system has a detection rate of 76%.
GOOD, BAD OR UGLY: DECODING UNION BUDGET-2022
Authors:   Anand Engineering College, Agra, Singh Thakur Sanjeev , Kumar Dr. Rachit ,   Anand Engineering College, Agra, Verma Deepti ,   Anand Engineering College, Agra
Published: June 2022

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OPTIMIZATION OF PRODUCTION AND BENEFITS OF USING LINEAR PROGRAMMING IN THE LINGGARJATI FURNITURE BUSINESS
Authors:   Bhayangkara Jaya University, Jakarta Indonesia, E.H.J. FoEh John , Asif Khan Dr Muhammad ,   Bhayangkara Jaya University, Jakarta Indonesia
Published: June 2022

Massive exploitation of natural forests and concentration in the plywood industry until the late 1980s caused Indonesia to currently experience a shortage of raw materials for the secondary (meuble) industry. Especially for teak, currently many furniture industries depend on the supply of sawn wood from the surrounding community forests. This study intends to determine the level of furniture production from PT. Linggarjati which relies on the sawn timber industry from the surrounding community forests in order to generate optimum profits. The secondary data used in this study were obtained from the company with interviews for data clarification which include, the production process, raw materials, supporting materials and implementation time related to each type of furniture produced. The analysis method uses Linear Programming with the help of ExcelQM software for Mac version 5.3. The constraint function used is teak wood raw material, various supporting materials for making furniture and labor hours. The results showed that only some types of furniture can be produced to provide optimal profit for Linggarjati furniture, among others; 3 three-door cabinets, 4 table sets with 6 chairs and 10 beds measuring 180 x 200 cm. From the combination of these products, it can produce an optimal profit of Rp. 33,518,275,- The results of this analysis show that the three types of furniture alone can provide a greater profit of 78.5% compared to producing and selling the 11 types of furniture that currently exist, the profit is only Rp. 18,776,693,- or with a difference of Rp. 14,741,582,-
ALCOHOL DETECTION AND VEHICLE STOPPING SYSTEM
Authors:   Velammal Engineering College, Chennai,, Sundararajan Sai Nithish , V Ponkarthikeyan ,   Velammal Engineering College, Chennai,, P Bowman ,   Velammal Engineering College, Chennai,
Published: June 2022

Accidents due to drunken drivers have increased in large scale leading to rise of questions about safety of roads. This has resulted in large damage to both life and assets. This proposed project deals with this issue in a more advantageous way using microcontrollers. It proposes a system that deals with design and implementation of Arduino driven Alcohol detector and engine locking system for cars. The alcohol concentration level will be monitored continuously by the alcohol sensor and the engine will be shut down if the alcohol concentration increases the permitted threshold level. The location of the vehicle will be set to the updated mobile number with the help of the installed GSM/GPS module. This helps in tracking down the vehicle in case of any emergencies.
IOT-BASED ENERGY METER FOR DISPLAYING CONSUMPTION STATISTIC
Authors:   JIS College of Engineering, Ghosal Sounetra , Banerjee Shubhojit ,   JIS College of Engineering, Kundu Souvik ,   JIS College of Engineering, Yadav Sangita ,   JIS College of Engineering
Published: June 2022

—Energy Meter is widely used a technology. It can be seen in everywhere. It can be found worldwide. It is useable in house or any industrial place also. Generally, it measures all the power consumed by the consumer & it gives the total consumption till that date by the consumer. The main problem is that the consumer can’t able to calculate how much he/she is consuming & also can’t reduce their misuse. This device will check current consumption & it will store data on basis of daily, monthly & yearly. By this way consumer can understand how much they are consuming & how much they are misusing. Also, they can make a statistic that how much they have consumed in last year summer & in present summer. As we are going to implement IoT it is going to show their consumption & it will give the whole data in excel sheet. Also, in excel sheet it will generate chat & bar diagram where consumption statistics will be clear to all consumers. IoT will help them to generate all data whenever it is needed. By this way they can stop their current m is use.
A STUDY ON FINANCIAL PERFORMANCE OF S.M.I.L.E MICROFINANCE LIMITED
Authors:   Sathyabama Institute of Science and Technology Chennai,Tamilnadu ,South India, Aarthi S. R. , Paulin Dr. M. Sudha ,   Sathyabama Institute of Science and Technology
Published: June 2022

Microfinance at first has been a type of deliberate assistance to the most denied populace. In any case, today it addresses a market answer for alleviation of destitution and goes about as a turn of events and financial device in achieving monetary consideration in India. Microfinance has arisen as a practical choice to come to the until recently unreached for their social and financial strengthening through friendly and monetary inter- mediation. The establishments that are giving microfinance administrations, for example, reserve funds, credit, protection and settlement administrations to poor are called Microfinance Institutions (MFIs). The review focuses on investigating the monetary presentation of S.M.I.L.E MICROFINANCE Restricted. The information have been gathered from the Microfinance Information Trade from the financial year 2015 to 2019. The measurable devices, to be specific, Descriptive insights and development rates have been utilized for investigating the information.. As far as in general monetary execution, Indian MFIs have better ROE and OSS. Indian MFIs have shown higher monetary income by resources, the yield on gross portfolio (ostensible) and lower working cost by resources, yet at the same time it couldn't cover the complete cost and monetary costs. In truth, Indian MFIs have uncovered better effectiveness and efficiency as estimated by working cost by advance portfolio, normal compensation by GNI per capita and advances per staff part.
A STUDY ON IMPACT OF ONLINE BANKING SERVICES AMONG SENIOR CITIZENS
Authors:   Sathyabama Institute of Science and Technology Chennai, Tamilnadu, South India, Archana S. , Paulin Dr. M.Sudha ,   Sathyabama Institute of Science and Technology Chennai, Tamilnadu, South India
Published: June 2022

: Advanced banking turned into the need of the general public and the earlier worry of banking authorities. The simplicity of banking administrations accessibility adds to the progress of virtual banking. Senior residents are viewed as the less adjusted class to this change. Dread and absence of mindfulness makes a divider among them and the financial utilizing on the web stages. Banking establishments are consistently putting forth attempts to oblige them to the virtual stage. In this situation, the review estimates the mindfulness level and utilization level of web based financial items among the senior classification and their discernment previously and experience in the wake of utilizing the internet based stages. The difficulties looked by the senior residents in advanced banking are likewise remembered for the domain of this review. Tests are gathered from 52 senior residents.
OBTAINING EXACT SOLUTIONS OF VISCOINCOMPRESSIBLE PARALLEL FLOWS USING PYTHON
Authors:   Jaypee University of Engineering and Technology, Singh Pawar Parth , R. Mishra Dhananjay ,   Jaypee University of Engineering and Technology, Dumka Pankaj ,   Jaypee University of Engineering and Technology
Published: June 2022

This paper applies the solution of ODE's encounter in fluid mechanics by augmenting it with symbolic Python. The implementation procedure has been illustrated for two types of parallel flows, i.e., Couette and Hagen Poiseuille flow. The suggestive results thus obtained are plotted and presented using Matplotlib. The manuscript will help beginners of fluid mechanics solve the fluid flow problems computationally and produce the results in a better way.
BITCOIN PRICE PREDICTION USING SVM
Authors:   DIT, Pimpri, Pune, Indi, Auti Ajinkya , Patil Dhananjay ,   DIT, Pimpri, Pune, Indi, Zagade Omkar ,   DIT, Pimpri, Pune, Indi, Bhosale Prasad ,   DIT, Pimpri, Pune, Indi, Ahire Prashant ,   DIT, Pimpri, Pune, India
Published: June 2022

Bitcoin is one of the most valuable Crypto currency in the world with the prices as high as 68,078 United States Dollar (USD) in November of 2021. It made Bitcoin a very profitable market for investment but Bitcoin saw many ups and down as well. Prices of Bitcoin have highly fluctuated which make them very difficult to predict. Hence, this research aims to discover the most efficient and highest accuracy model to predict Bitcoin prices from various machine learning algorithms. By using 1-minute interval trading data on the Bitcoin exchange website named bitstamp some different regression models with Scikit- learn and Keras libraries had experimented. The dataset used contains minute by minute prices of Bitcoin of over 5 years and contains almost 3 Million entries. Since, the dataset used is a big data, evaluating the performance of algorithms over a large dataset will give accurate results.
The Global Impact of COVID-19 Misinformation and Politicization on Vaccination Compliance
Authors: Buckingham Robert W , Ferretti Renata , Adams Brittany , Kepon Timolin
Published: June 2022

Vaccine hesitancy regarding the COVID-19 vaccine is widespread and disadvantageous. Anti-vax beliefs threaten health systems and open pathways for reemerging infectious diseases. In order to begin a return to normalcy around the world, high vaccination rates are necessary but are not currently being witnessed. This paper discusses two hypotheses to explain the hesitancy surrounding the COVID-19 vaccine: exposure to misinformation and the politicization of COVID-19. Misinformation and politicization by governments, political parties, and the media will continue to make the COVID-19 pandemic more harmful than it needs to be.
A constituição de uma elite rural: o caso dos sojicultores em Mato Grosso do Sul (décadas de 1970-80)
Authors: Moro Nataniél Dal
Published: June 2022

O poder público federal, sobretudo a partir da instauração da Ditadura Civil Militar de março de 1964, incentivou abertamente a ocupação de terras do oeste brasileiro com algumas monoculturas, em especial as do milho e da soja. Essa política intensificou ainda mais a migração de sulistas à região hoje chamada de Estado de Mato Grosso do Sul. No final da década de 1960 já havia plantio de soja em algumas áreas, contudo, a produção e a produtividade eram muito aquém da desejada. No decorrer das décadas de 1970-80, a produção agrícola realizada pelos sojicultores se tornou cada vez mais significativa no âmbito estadual. A presença dessas pessoas não ficou restrita ao espaço rural, já que ocuparam também ambientes sociais e institucionais nas cidades. Tendo em vista essa concretude histórica e social, este artigo problematiza como esses migrantes, em particular os que trabalhavam com a monocultura da soja, se constituíram numa elite rural de Mato Grosso do Sul.
Everardo Adolpho Backheuser: expoente de um escolanovismo católico
Authors: Rosa Maristela da , Teive Gladys Mary Ghizoni
Published: June 2022

A partir de uma microanálise sócio-histórica, este artigo intenta apontar indícios para a compreensão da trajetória social do intelectual Everardo Adolpho Backheuser no campo educacional, como expoente de um ‘escolanovismo católico’. Ao entender a trajetória social como o movimento empreendido pelo agente dentro do campo, descreve-se o seu perfil biográfico citando a origem sociofamiliar e os percursos escolares; e, sublinha-se, a atuação deste intelectual dentro do campo pedagógico e a sua posição na querela entre católicos e escolanovistas. O corpus conceitual, de inspiração bourdieusiana, que fundamentou este texto, bem como as fontes selecionadas, são apresentados no decorrer da narrativa.
Formação de professores em exercício: o olhar sobre os problemas de aprendizagem
Authors: Masuyama Paula Mieco Koizumi , Rinaldi Renata Portela
Published: June 2022

Este artigo apresenta os resultados de uma experiência de pesquisa coletiva, financiada pelo CNPQ, com professores, gestor e orientador pedagógico em uma escola de anos iniciais do Ensino Fundamental. O objetivo do estudo é analisar os resultados da aprendizagem profissional e as práticas apresentadas pelos participantes quanto aos problemas de aprendizagem. A pesquisa, de natureza qualitativa, se desenvolveu no contexto escolar e a coleta de dados ocorreu por meio de narrativas escritas. Os resultados apontam para a necessidade de investir em ações formativas de natureza multidisciplinar com espaço para reflexão coletiva de esclarecimento, problematização e construção conjunta de estratégias e intervenções para o ensino no contexto escolar.
Study on Exosomes Promoting the Osteogenic Differentiation of ADSCs in Graphene Porous Titanium Alloy Scaffolds
Authors: Sun Xu , Yang Shude , Tong Shuang , Guo Shu
Published: June 2022

Titanium and titanium alloys (Ti6Al4V and Ti) have been widely used in bone tissue engineering to repair maxillofacial bone defects caused by traumas and tumors. However, such materials are also bio-inert, which does not match the elastic modulus of bone. Therefore, different surface modifications have been proposed for clinical application. Based on the use of traditional titanium alloy in the field of bone repair defects, we prepared a compound Gr-Ti scaffold with ADSC-derived Exos. The results showed that Gr-Ti scaffolds have low toxicity and good biocompatibility, which can promote the adhesion and osteogenic differentiation of ADSCs. Exos played a role in promoting osteogenic differentiation of ADSCs: the mRNA levels of RUNX2, ALP, and Osterix in the Gr-Ti/Exos group were significantly higher than those in the Gr-Ti group, which process related to the Wnt signaling pathway. Gr-Ti scaffolds with ADSCs and ADSC-derived Exos successfully repaired rabbit mandibular defects. The bone mineral density and the bending strength of the Gr-Ti/Exos group was significantly higher than that of the Gr-Ti group. This study provides a theoretical basis for the research and development of new clinical bone repair materials.
3-Dimensional Model to Study Apoptosis Induction of Activated Natural Killer Cells Conditioned Medium Using Patient-Derived Colorectal Cancer Organoids
Authors: Parseh Benyamin , Khosravi Ayyoob , Fazel Abdolreza , Ai Jafar , Ebrahimi-Barough Somayeh , Verdi Javad , Shahbazi Majid
Published: June 2022

Natural killer (NK) cells are innate lymphocytes that can kill tumor cells via different pathways, including the secretion of cytotoxic granules in immunological synapses and the binding of apoptosis-inducing ligands with cognate death receptors on tumor cells. These ligands are also soluble in NK cells conditioned medium (NK-CM). However, novel preclinical in vitro models are required for solid tumors such as colorectal cancer (CRC) to investigate apoptosis induction of activated NK-CM in a tissue-like structure. In the present study, we established a patient-derived CRC organoid culture system as a new tool for CRC research in the last decade. Tumor organoids were stained with hematoxylin and eosin (H&E) and compared with the original tumor taken from the patient. Goblet cell differentiation and mucus secretion were evaluated using periodic acid–Schiff and alcian blue histochemical staining. Moreover, tumor organoids were stained for CDX2 and Ki67 markers with immunohistochemistry (IHC) to investigate gastrointestinal origin and proliferation. Histopathological evaluations indicated tumor organoids represent patient tumor characteristics. Primary NK cells were isolated and characterized using CD56 marker expression and the lack of the CD3 marker. Flow cytometry results showed the purity of isolated CD3−and CD56 + NK cells about 93%. After further ex vivo expansion, IL-2-activated NK-CM was collected. Secretions of IFN-γ and TNF-α were measured to characterize activated NK-CM. Cytokines levels were significantly elevated in comparison to the control group. Soluble forms of apoptosis-inducing ligands, including TNF-related apoptosis-inducing ligand (TRAIL) and FasL, were detected by western blot assay. Colon cancer organoids were treated by IL-2-activated NK-CM. Apoptosis was assessed by Annexin V-FITC/PI staining and quantified by flow cytometry. In conclusion, despite the activated NK-CM containing apoptosis-inducing ligands, these ligands’ soluble forms failed to induce apoptosis in patient-derived colon cancer organoids. Nevertheless, we report a reliable in vitro assessment platform in a personalized setting.
Biodegradable Zn-Cu-Fe Alloy as a Promising Material for Craniomaxillofacial Implants: An in vitro Investigation into Degradation Behavior, Cytotoxicity, and Hemocompatibility
Authors: Xu Yan , Xu Yichen , Zhang Wentai , Li Ming , Wendel Hans-Peter , Geis-Gerstorfer Jürgen , Li Ping , Wan Guojiang , Xu Shulan , Hu Tao
Published: June 2022

Zinc-based nanoparticles, nanoscale metal frameworks and metals have been considered as biocompatible materials for bone tissue engineering. Among them, zinc-based metals are recognized as promising biodegradable materials thanks to their moderate degradation rate ranging between magnesium and iron. Nonetheless, materials’ biodegradability and the related biological response depend on the specific implant site. The present study evaluated the biodegradability, cytocompatibility, and hemocompatibility of a hot-extruded zinc-copper-iron (Zn-Cu-Fe) alloy as a potential biomaterial for craniomaxillofacial implants. Firstly, the effect of fetal bovine serum (FBS) on in vitro degradation behavior was evaluated. Furthermore, an extract test was used to evaluate the cytotoxicity of the alloy. Also, the hemocompatibility evaluation was carried out by a modified Chandler-Loop model. The results showed decreased degradation rates of the Zn-Cu-Fe alloy after incorporating FBS into the medium. Also, the alloy exhibited acceptable toxicity towards RAW264.7, HUVEC, and MC3T3-E1 cells. Regarding hemocompatibility, the alloy did not significantly alter erythrocyte, platelet, and leukocyte counts, while the coagulation and complement systems were activated. This study demonstrated the predictable in vitro degradation behavior, acceptable cytotoxicity, and appropriate hemocompatibility of Zn-Cu-Fe alloy; therefore, it might be a candidate biomaterial for craniomaxillofacial implants.
Thermophysical Properties of Alkanone + Aromatic Amine Mixtures at Varying Temperatures
Authors: Prabhune Aditi , Natekar Amrita , Dey Ranjan
Published: June 2022

In the present investigation, an attempt has been made to evaluate internal pressure(Pi), energy(ΔEvap), and enthalpy of vaporization(ΔHvap)along with excess entropy(SE) and excess isothermal compressibility(βTE)for binary solutions of alkanones (2-propanone, 2-butanone, and 2-heptanone) and aromatic amines (aniline, N-methylaniline, and pyridine) at 293.15, 298.15, and 303.15 K, respectively. The cohesive energy density (CED) and solubility parameter(δ)are studied to understand the strength of molecular interactions. The coefficient of thermal expansion(α)and isothermal compressibility(βT)have also been investigated using empirical equations and have been employed to understand the molecular interactions. All the evaluated properties have been used to understand the nature and extent of intermolecular interactions taking place. The observed trends in the properties and their variations have been discussed in terms of varying chain lengths of the alkyl group and the hydrogen bonding capability of the components. The findings show that the extent of interactions follows an order: aniline > NMA > pyridine, keeping the alkanone constant at all the temperatures under study.
Endosulfan Elimination Using Amine-Modified Magnetic Diatomite as an Adsorbent
Authors: Alacabey İhsan
Published: June 2022

Pesticides are among the most dangerous developing toxins since they are very hazardous to the environment and threaten human health. In this study, researchers successfully manufactured surface-modified magnetic diatomite (m-DE-APTES) and used them as a sorbent to extract endosulfan from an aqueous solution. There is no other study like it in the scholarly literature, and the results are astounding. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive X-ray (EDX), electron spin resonance (ESR), and surface area measurements were used to analyze magnetic diatomite particles with surface modification. According to the analysis results, magnetic diatomite has a wide surface area and a porous structure. Furthermore, m-DE-APTES has a higher endosulfan adsorption capacity (97.2 mg g−1) than raw diatomite (DE) (16.6 mg g−1). Adsorption statistics agree with Langmuir adsorption isotherm (R2 = 0.9905), and the adsorption occurred spontaneously at −2.576 kj mol−1 in terms of ΔGo. Finally, m-DE-APTES are a viable alternative adsorbent for removing pesticides from aqueous solutions.
In vivo Visualization of Collagen Transdermal Absorption by Second-Harmonic Generation and Two-Photon Excited Fluorescence Microscopy
Authors: Sun Yanan , Li Lishuang , Ma Shuhua , He Gaiying , Yang Weifeng , Wang Yi
Published: June 2022

The transdermal administration of collagen is an important method used for wound healing and skin regeneration. However, due to the limitations of previous approaches, the process and degree of collagen transdermal absorption could only be quantitatively and qualitatively evaluated in vitro. In the present study, we introduced a novel approach that combines second-harmonic generation with two-photon excited fluorescence to visualize the dynamics of collagen transdermal absorption in vivo. High-resolution images showed that exogenous recombinant human collagen permeated the epidermis through hair follicles and sebaceous glands reached the dermis, and formed reticular structures in real time. We also validated these findings through traditional in vitro skin scanning and histological examination. Thus, our approach provides a reliable measurement for real-time evaluation of collagen absorption and treatment effects in vivo.
Large-Scale Analysis of Fitness Cost of tet(X4)-Positive Plasmids in Escherichia coli
Authors: Tang Feifei , Cai Wenhui , Jiang Lijie , Wang Zhiqiang , Liu Yuan
Published: June 2022

Tigecycline is one of important antimicrobial agents for the treatment of infections caused by multidrug-resistant (MDR) Gram-negative bacteria. However, the emergence and prevalence of plasmid-mediated tigecycline resistance gene tet(X4) are threatening human and animal health. Fitness cost elicited by resistance plasmids is a key factor affecting the maintenance and transmission of antibiotic resistance genes (ARGs) in the host. A comparative analysis of the fitness cost of different types of tet(X4)-positive plasmids is helpful to understand and predict the prevalence of dominant plasmids. In this study, we performed a large-scale analysis of fitness cost of tet(X4)-positive plasmids origin from clinical isolates. These plasmids were successfully electroporated into a reference strain Escherichia coli TOP10, and a series of transformants carrying the tet(X) gene were obtained. The effects of tet(X4)-positive plasmids on the growth rate, plasmid stability, relative fitness, biofilm formation, and virulence in a Galleria mellonella model were evaluated. Consequently, we found that these plasmids resulted in varying degrees of fitness cost on TOP10, including delayed bacterial growth and attenuated virulence. Out of these plasmids, tet(X4)-harboring IncFII plasmids showed the lowest fitness cost on the host. Furthermore, by means of experimental evolution in the presence of commonly used drugs in clinic, the fitness cost of tet(X4)-positive plasmids was substantially alleviated, accompanied by increased plasmid stability. Collectively, our data reveal the differential fitness cost caused by different types of tet(X4)-positive plasmids and suggest that the wide use of tetracycline antibiotics may promote the evolution of plasmids.
Development of a Cleaved Probe-Based Loop-Mediated Isothermal Amplification Assay for Rapid Detection of African Swine Fever Virus
Authors: Wang Songqi , Shen Haiyan , Lin Qijie , Huang Jun , Zhang Chunhong , Liu Zhicheng , Sun Minhua , Zhang Jianfeng , Liao Ming , Li Yugu , Zhang Jianmin
Published: June 2022

African Swine Fever (ASF), caused by African swine fever virus (ASFV), is a highly contagious and lethal viral disease of pigs. However, commercial vaccines are not yet available, and neither are drugs to prevent or control ASF. Therefore, rapid, accurate on-site diagnosis is urgently needed for detection during the early stages of ASFV infection. Herein, a cleaved probe-based loop-mediated isothermal amplification (CP-LAMP) detection method was established. Based on the original primer sets, we targeted the ASFV 9GL gene sequence to design a probe harboring a ribonucleotide insertion. Ribonuclease H2 (RNase H2) enzyme activity can only be activated when the probe is perfectly complementary, resulting in hydrolytic release of a quencher moiety, and consequent signal amplification. The method displayed robust sensitivity, with copy number detection as low as 13 copies/µL within 40 min at constant temperature (62°C). Visualization of the fluorescence product was employed using a self-designed 3D-printed visualization function cassette, and the CP-LAMP method achieved specific identification and visual detection of ASFV. Moreover, coupling the dual function cassette and smartphone quantitation makes the CP-LAMP assay first user-friendly, cost-effective, portable, rapid, and accurate point-of-care testing (POCT) platform for ASFV.
Comparison of the Efficacy and Safety Endpoints of Five Therapies for Atrial Fibrillation: A Network Meta-Analysis
Authors: Wang Tongyu , Fang Tingting , Cheng Zeyi
Published: June 2022

Introduction

Atrial fibrillation (AF) is a prevalent arrhythmia that occurs in 2–4% of adults and poses a threat to human health. Thus, comparison of the efficacy and safety of therapies for AF is warranted. Here, we used network analysis to compare efficacy (arrhythmia recurrence and re-hospitalization) and safety (ischemic cerebral vascular events, all-cause mortality, and cardiovascular mortality) endpoints among five major therapies for AF.

Methods

The PubMed, Cochrane, and Embase databases were searched, and relevant literature was retrieved. Only studies that made comparisons among the therapies of interest and involved patients with AF were included. Pairwise comparisons and frequentist method (SUCRA plot) analyses were conducted.

Results

In total, 62 studies were included in the pooled analysis. In pairwise comparisons, atrioventricular nodal ablation plus permanent pacemaker (AVN + PPM) was associated with a significantly higher risk of atrial arrhythmia recurrence than surgical ablation [odds ratio (OR): 23.82, 95% confidence interval (CI): 1.97–287.59, fixed-effect model; 3.82, 95% CI: 1.01–559.74, random-effects model]. Furthermore, radiofrequency ablation was associated with a significantly lower risk of cardiovascular mortality than medication in pairwise comparison (OR: 0.49, 95% CI: 0.29–0.83, fixed-effect model; OR: 0.49, 95% CI: 0.27–0.9, random-effects model). Frequentist analysis indicated that AVN + PPM had the best performance in reducing the risk of safety and efficacy endpoints.

Conclusion

Non-pharmaceutical therapies showed superior performance to traditional drug therapy in lowering the risk of safety and efficiency endpoint events. AVN + PPM performed best in reducing the risk of safety and efficacy endpoints.
Awareness and Feasibility of Women Chairing Cardiology Sessions in Scientific Meetings: A Nationwide Survey by the Japanese Circulation Society
Authors: Nakayama Atsuko , Kamiya Chizuko A. , Kanki Sachiko , Ide Tomomi , Bando Yasuko K. , Uemura Yukari , Tsukada Yayoi Tetsuou
Published: June 2022

Background

Diversity and inclusion remain a concern in the field of cardiology. Female cardiologists have less opportunity to chair sessions in scientific meetings than men. However, cardiologists’ awareness and perspectives on feasibility of chairing sessions is poorly understood.

Methods and Results

A web-based survey on awareness regarding the commitment of chairing sessions was sent to 14,798 certificated cardiologists registered with the Japanese Circulation Society (JCS). A total of 3,412 valid responses were obtained, such as 523 women and 2,889 men. Female cardiologists exhibited less interest in serving as chairpersons in Japanese and English sessions (71% women vs. 82% men, p < 0.001, 30% women vs. 40% men, p < 0.001). Influencing factors of chair acceptance in Japanese sessions for female cardiologists were being a cardiologist for over 10 years [odds ratio (OR) 1.84, 95% confidence interval (CI) 1.02–3.33], experience studying abroad (OR 3.35, 95% CI 1.93–5.81) and chairing sessions (OR 8.39, 95% CI 5.48–12.9), having a Doctor of Philosophy (OR 2.82, 95% CI 1.09–7.31), presence of 4 or more female cardiovascular specialists in the hospital (OR 1.70, 95% CI 1.10–2.61) and of role models (OR 2.86, 95% CI 1.93–4.24), and awareness of the JCS chairperson’s manual (OR 10.7, 95% CI 6.67–17.1). The receiver operating characteristic (ROC) curve revealed that the number of female cardiovascular specialists in a hospital was a more sensitive predictor of chair acceptance among male than female cardiologists.

Conclusions

Female cardiologists were less likely to accept chairing sessions compared with male cardiologists and the presence of female cardiovascular specialists positively influenced chair acceptance.
The Risk of Thrombosis Around Pregnancy: Where Do We Stand?
Authors: Gris Jean-Christophe , Guillotin Florence , Chéa Mathias , Bourguignon Chloé , Bouvier Sylvie
Published: June 2022

Pregnancy and puerperium increase the relative risk of venous thromboembolism (VTE) and the absolute risk remains low, around 1 per 1,000, with induced mortality of around 1 per 100,000. Analysis of large databases has helped specify the modes of presentation and risk factors (RF) whose impact is greater after than before childbirth, since VTE during pregnancy and post-partum obey different RFs. The evolution of the population concerned (mostly women over 35, obese, of multi-ethnicity undergoing medically assisted reproduction) affects the frequency of these RFs. Pulmonary embolism (PE) is over-represented after childbirth, but 30% of PE in pregnancy occurs without any RFs. Recommendations for prevention, mainly from expert groups, are heterogeneous and often discordant. Low molecular weight heparins (LMWH) are the mainstay of pharmacological thromboprophylaxis, in a field where randomized controlled studies are definitely lacking. VTE risk assessment in pregnancy must be systematic and repetitive. Risk assessment methods and scores are beginning to emerge to guide thromboprophylaxis and should be used more systematically. In the future, analyzing observational data from huge, nationwide registries and prospective cluster clinical trials may bring to light clinically relevant outcomes likely to feed comprehensive guidelines.
Left Atrial Appendage Mechanical Dispersion Assessed by Speckle-Tracking Echocardiography as a Determinant of Left Atrial Appendage Blood Stasis in Patients With Atrial Fibrillation
Authors: Mao Yankai , Zhao Huajie , Yu Chan , Yang Yuan , Ma Mingming , Wang Yunhe , Jiang Ruhong , Zhao Bowen , Zheng Zhelan , Jiang Chenyang
Published: June 2022

Aims

We sought to investigate the relationship of left atrial appendage (LAA) mechanical dispersion (MD) with LAA dense spontaneous echo contrast (SEC) or thrombus, and to compare its usefulness in the identification of thrombogenesis with left atrial (LA) MD or LA/LAA strain parameters in patients with atrial fibrillation (AF).

Methods

We conducted a cross-sectional study of 493 consecutive patients with AF [65(58.5–71.0) years, male 66.9%] who underwent echocardiography prior to catheter ablation. We measured the LAA and LA global longitudinal strain (GLS) using speckle-tracking echocardiography (STE). LAA MD and LA MD was defined as the standard deviation (SD) of time to peak positive strain corrected by the R-R interval.

Results

Patients with LAA dense SEC/thrombus (n = 70) had significantly higher LAA MD than controls (n = 423) [median 14.2(11.6–16.8)% vs 9.4(6.2–12.1)%, p < 0.01]. Multivariable analysis showed that LAA MD was independently associated with LAA dense SEC/thrombus in four different models (Odds ratio, 1.23–1.24; p < 0.01), and provided additional diagnostic value over clinical and standard echocardiographic parameters. Whereas, LA MD was not independently associated with LAA dense SEC/thrombus and had no incremental value over other LA/LAA mechanical parameters.

Conclusion

LAA mechanical dispersion was an independent determinant of LAA dense SEC/thrombus in AF patients, incremental to conventional risk factors and superior to LA mechanical dispersion.
Application of Hydrothermal Altered Reservoir Identification Method in Metamorphic Rock Buried Hill of Bozhong sag, Bohai Bay Basin, China
Authors: Zhu Boyuan , Pan Renfang , Zhang Chaomo , Zhang Zhansong , Shi Wenrui
Published: June 2022

Hydrothermal fluid is one of the factors controlling Archean buried hill reservoirs in Bozhong 19-6. However, there are no clear studies focusing on the influence of hydrothermal alteration products and their lithological characteristics on reservoirs. Through characterization of the alteration reservoir and construction of a new subtraction model of the logging-rock mechanical alteration degree, the comprehensive uses of core, thin section, and electrical imaging logging data are considered as the research objects with metamorphic and igneous rocks. Thus, the relationship between lithologies with different alteration degrees and reservoir quality is revealed. The study shows that feldspar chloritization and sericitization are the main factors controlling the hydrothermal alteration of the reservoir; the overall alteration degree of igneous rocks is high, and the overall alteration degree of metamorphic rocks is low; the reservoir with strongly altered igneous facies is prone to forming dissolution pores, with strong reservoir inhomogeneity and poor reservoir performance (alteration degree is greater than 15%); the reservoir with weakly altered metamorphic facies is prone to developing fractures and a high reservoir productivity (alteration degree is 0); The reservoirs with altered metamorphic facies are numerous in the formation, spatially diverse in type, and second in reservoir quality only to those in the weakly altered metamorphic facies (alteration degree of 0–15%). This method is expected to provide a reference for quickly finding advantageous reservoirs in the Bohai Sag.
Dune Field Patterns and Their Control Factors in the Middle Areas of China’s Hexi Corridor Desert
Authors: Zhang Yan , Zhang Zhengcai
Published: June 2022

The middle areas of China’s Hexi Corridor Desert are distributed within or at the edge of oases in continental river basins in Northern China. Recently, researchers found that rivers can provide sediment material for dune formation and development, but the mechanism has not been investigated in detail. In this study, the relationships among the wind environment, spatial distribution of continental rivers, sand availability, and dune field patterns in the middle area of Hexi Corridor Desert were analyzed. In terms of the wind energy environment, the study area can be divided into three regions: high-energy environment in the north, intermediate-energy environment in the middle, and low-energy environment in the south. The results showed that the resultant drift potential is predominantly from the NW quadrant. The directional variability of wind is intermediate in the northern and middle region and low in the southern region. The directions of winds with critical speed are SW in the northern region, NW and WNW in the middle region, and NW in the southern region. The main dune types are barchans, reticulate dunes, star dunes, linear dunes, and coppice dunes, which differ from previous results (mainly barchans and coppice dunes). Dune field patterns are controlled by the wind energy environment. In addition, the spatial distribution of continental rivers and sand availability are important factors affecting dune formation and development. Sand dunes are distributed downwind of continental rivers, which confirms the hypothesis that rivers can provide sediment material for dune formation. The spatial distribution and different dune types in the middle area of Hexi Corridor Desert reveal that their formation and development are controlled by the wind regime and sediment supply.
Adverse Effects of Polycystic Ovarian Syndrome on Pregnancy Outcomes in Women With Frozen-Thawed Embryo Transfer: Propensity Score-Matched Study
Authors: Ni Zhexin , Mei Shanshan , You Siting , Lin Yi , Cheng Wen , Zhou Ling , Kuang Yanping , Yu Chaoqin
Published: June 2022

Purpose

This work aimed to evaluate the adverse effect of polycystic ovary syndrome (PCOS) on pregnancy outcomes of singletons after vitrification in women with frozen-thawed embryo transfer (FET).

Methods

Patients with/without PCOS who underwent FET from January 2013 and December 2018 were included. Propensity score matching (PSM) was used to reduce the influence of bias. Logistic regression was applied to identify the risk factors of adverse pregnancy outcomes of singletons in women with PCOS.

Result

After PSM, the PCOS group had shorter gestational age (P<0.001) and lower newborn birth weight than the non-PCOS group (P=0.045). Compared with the non-PCOS group, the PCOS group had an increased risk of gestational diabetes mellitus (GDM) and pregnancy-induced hypertension (PIH) (P<0.001), placenta and membrane abnormality (P<0.001), stillbirth (P<0.001), neonatal complication (P=0.014), and miscarriage rate (P<0.001). Neonatal complication was associated with parity (adjusted OR=1.202, 95% CI=1.002–1.443, P=0.048) and basal P level (adjusted OR=1.211, 95% CI=1.021–1.436, P=0.028). According to multivariable logistic regression analysis, the miscarriage rate was related to parity (adjusted OR=1.201, 95% CI=1.057–1.166, P=0.005) and basal E2 (adjusted OR=1.002, 95% CI=1.000–1.004, P=0.019) and P levels on the day of embryo transfer (adjusted OR=0.971, 95% CI=0.957–0.985, P<0.001).

Conclusions

Compared with non-PCOS women, women with PCOS have a higher risk of GDM and PIH, and neonatal complications and therefore require additional care during pregnancy and parturition.
Characterization of the Interrenal Gland and Sexual Traits Development in cyp17a2-Deficient Zebrafish
Authors: Shi Shengchi , Shu Tingting , Li Xi , Lou Qiyong , Jin Xia , He Jiangyan , Yin Zhan , Zhai Gang
Published: June 2022

Unlike the Cytochrome P450, family 17, subfamily A, member 1 (Cyp17a1), which possesses both 17α-hydroxylase and 17,20-lyase activities involved in the steroidogenic pathway that produces androgens and estrogens, Cytochrome P450, family 17, subfamily A, polypeptide 2 (Cyp17a2) possesses only 17α-hydroxylase activity and is known essential for the synthesis of cortisol. Besides with expressed in testes and ovaries, where the cyp17a1 is mainly expressed, cyp17a2 is also expressed in the interrenal gland in fish. Until now, the roles of cyp17a2 in fish, especially in sexual traits development and hypothalamic-pituitary-interrenal (HPI) axis, are poorly studied. To investigate the roles of Cyp17a2 in teleosts, the cyp17a2-null zebrafish was generated and analyzed by us. The significantly decreased cortisol concentration was observed both in the cyp17a2-deficient males and females at adult stage. The interrenal gland enlargement, increased pituitary proopiomelanocortin a (pomca) expression, decreased locomotion activity and response to light-stimulated stress were observed in cyp17a2-deficient fish. Intriguingly, the cyp17a2-deficient males were fertile and with normal breeding tubercles on the pectoral fin, but females were infertile, deficient in genital papilla and with decreased gonadosomatic index (GSI). The increased progesterone (P4), 17α,20β-dihydroxy-4-pregnen-3-one (DHP) and 11-ketotestosterone (11-KT) in the cyp17a2-deficient males and females were observed. The increased concentration of testosterone (T) and estradiol (E2) was observed in cyp17a2-/- females and cyp17a2-/- males, respectively. By examining the ovaries development of cyp17a2-deficient fish at 3 months postfertilization (mpf), we observed that the oocytes were over-activated. Taken together, our findings demonstrate that Cyp17a2 is indispensable for production and physiology of cortisol, and cyp17a2-deficiency resulted in diminished cortisol but accumulated P4 and DHP, which may result in the over-activated oocytes in cyp17a2-deficient females.
Self-Water-Removal and Voltage Behavior Improvement of Dead-Ended Proton Exchange Membrane Fuel Cell Stack at Steady-State and Dynamic Conditions
Authors: Pei Houchang , Xiao Chenguang , Xing Lu , Tu Zhengkai
Published: June 2022

The proton exchange membrane fuel cell (PEMFC) demonstrates high commercial competitiveness due to its advantages: low operating temperature, high power/mass ratio, fast response, no emission, and low noise. Thermal and water management remains a challenging issue for ensuring the fuel cell’s performance at steady-state and dynamic conditions. The cathode moisture condensation uses a semiconductor cooler to effectively remove excess water from the PEMFCs and reduce the probability of flooding of the stack. The stack’s voltage uniformity is an essential factor that affects the performance and lifetime of PEMFC. This paper investigates the dynamic response characteristics of the voltage uniformity of a PEMFC stack under cathode moisture condensation conditions. The results show that the condensation temperature at 10°C during the steady-state or transient operation of the PEMFC can effectively optimize the stack’s performance. Compared to conventional PEMFC, applying the cathode moisture condensation technology to the PEMFC stack increases the stack voltage by 6% and decreases the voltage uniformity by up to 30%. This self-water-removal technology effectively improves the voltage uniformity of the stack, which then increase the stack durability.
Research on Multi-Mode Operation and Coordinated Control Strategy of Grid-Connected Photovoltaic/Biogas/Energy-Storage System for Rural Ecological Breeding
Authors: Zhang Xinhe , He Guixiong , Xiong Junjie , He Wei , Xiao Changlin
Published: June 2022

Driven by the rural revitalization strategy and the carbon neutrality goals, the grid-connected photovoltaic/biogas/energy-storage (PV/biogas/ES) system is increasingly widely used in rural China. In this paper, a coordinated operation and control strategy of grid-connected PV/biogas/ES system for rural ecological breeding is proposed. Biogas, ES, and controllable load can adjust their operation state based on meeting constraint conditions to prevent overload from affecting the distribution transformer service life. The line voltage and load can adjust the ES control strategy. The peak shaving and valley filling can be realized through orderly charge/discharge control, in normal operation. Based on virtual synchronous generator (VSG) control, the ES has a certain frequency modulation ability. Meanwhile, overcharge, and over discharge can be avoided by detecting the state of charge (SOC) and adjusting the output power. When the line voltage drops suddenly, VSG can be switched to reactive power compensation mode. The battery energy storage system (BESS) and grid-connected inverter constitute a STATCOM/BESS, which can provide continuous reactive current to the grid to raise the line voltage and improve the system reliability. The effectiveness of the proposed strategy is verified by MATLAB/Simulink simulation.
Thermodynamic Analysis of a Combined Recompression Supercritical Carbon Dioxide Brayton Cycle With an Organic Flash Cycle for Hybrid Solar-Geothermal Energies Power Generation
Authors: Que Yi , Hu Zhiming , Ren Song , Jiang Zhang
Published: June 2022

Exploring renewable energy is beneficial for ameliorating the energy crisis and reducing environmental emissions. The hybrid utilization of solar and geothermal energies is an effective way to improve the existing energy consumption structure dominated by fossil energy. This paper proposes a novel power generation system composed of a topping recompression supercritical carbon dioxide (sCO2) Brayton cycle and a bottom organic flash cycle (OFC) driven by the hybrid solar-geothermal energies. The sCO2 Brayton cycle is driven by the heat from the solar tower system, and the OFC is driven by a part of the heat from CO2 in the sCO2 Brayton cycle and another part of the heat from the geothermal water. The corresponding energy and exergy analyses of the proposed combined system are presented. The effects of the five main parameters on the system thermodynamic performance are carried out, which are direct radiation intensity, concentration ratio, sCO2 pressure ratio, preheater terminal temperature difference, and flash temperature. Results show that the OFC with R245ca has the highest exergy efficiency among the different four fluids. The energy efficiency and exergy efficiency of the total system are 26.03% and 33.38%, respectively, since the energy losses exist in the heliostat field and central receivers. There observes that through the parametric study the parameters of direct radiation intensity and concentration ratio are larger causing better system thermodynamic performance. Through the thermodynamic analysis, there observes the power cycle subsystem has the largest energy loss, while the central receiver possesses the highest among other subsystems.