bluuebunny/crossref_metadata_2025 huggingface dataset:
Расчетно-экспериментальные исследования прочности ортотропных пластин с прямыми и зенкованными отверстиями
Authors:   ФГБОУ ВО «Московский авиационный институт (национальный исследовательский университет)», Москва, Россия, Вестяк В.А. , Смагин Е.И. ,   ПАО «Яковлев», Москва, Россия, Мартиросов М.И. ,   ФГБОУ ВО «Московский авиационный институт (национальный исследовательский университет)», Москва, Россия,   ПАО «Яковлев», Москва, Россия
Published: January 2025

Проведенные расчетно-экспериментальные исследования показывают, что ортотропные пластины подвержены сильному влиянию геометрических концентраторов и типа соединения. Введение потайного крепежа в односрезном соединении снижает несущую способность относительно прямого отверстия и не может быть учтена путем пропорционального пересчета на уменьшенную площадь сечения. Данный подход на примере изучаемого ортотропного материала на основе эпоксидной матрицы и высокомодульного волокна (ПКМ типа углепластика) позволяет значительно увеличить площадь области несущей способности. Выполненные расчеты несущей способности образцов показал, что моделирование эксперимента дает приемлемый уровень погрешности (около 15%) и может быть использован при проведении дальнейшей работы по оценке совместного влияния смятия и проходящей нагрузки на несущую способность соединения.
Impact of Tranexamic Acid on Clinical Outcomes in Patients with Hemorrhagic Stroke: A Comprehensive Review
Authors:   Clinical Research Coordinator, Department of Neurology, Christian Medical College and Hospital, India, Arora Rimpi ,   Clinical Research Coordinator, Department of Neurology, Christian Medical College and Hospital, India
Published: January 2025

Background: Hemorrhagic stroke, characterized by the rupture of blood vessels within the brain, leads to significant morbidity
and mortality. Tranexamic acid (TXA), an antifibrinolytic agent, has been explored for its potential to stabilize clots and
reduce hemorrhage expansion. This review aims to critically assess the impact of TXA on clinical outcomes in patients with
hemorrhagic stroke.
Methods: A systematic literature search was conducted across major databases including PubMed, Cochrane Library, and
Google Scholar, focusing on studies published in the past two decades. Keywords included “tranexamic acid,” “hemorrhagic
stroke,” “intracerebral hemorrhage,” and “clinical outcomes.” Both randomized controlled trials (RCTs) and observational
studies were included. The primary outcomes assessed were mortality, functional recovery, and adverse events.
Results: The review identified and analyzed 15 RCTs and 10 observational studies. Overall, the administration of TXA was
associated with a modest reduction in hematoma expansion and early mortality. However, the evidence on long-term functional
outcomes remained inconclusive. Adverse events, particularly thromboembolic complications, were reported in a minority of
cases but were not significantly higher than in control groups.
Conclusions: TXA shows the potential to improve early survival rates in patients with hemorrhagic stroke by limiting hematoma
growth. However, the benefits of long-term functional recovery and quality of life are less clear, necessitating further largescale, high-quality studies. Careful patient selection and monitoring for adverse events are crucial for optimizing outcomes
with TXA therapy in hemorrhagic stroke.
Personality New Equilibrium Theory
Authors:   24 rue des Peupliers 25700 Mathay France, Paleni Didier
Published: January 2025

An invariable principle of definition is applied to the study of personality. The balance between its fundamental components,
namely the affect, the intellect and the physique, characterizes man in his individuality and his intra-family and social relations.
The data of neuropsychology, concerning the role of memories, and those of contemporary psychology allow to reconsider this
balance, the mechanisms of imbalances as well as psychic disorders related to attempts at correction. If the role and functioning
of the sensitivities, during the emanations of this personality, join the Freudian model of intellectual-instinctive antagonism,
they extend it to the intuitive and sensitive domains. The relationships in time between anticipatory projection and memory
retrojection, and the dialogue between Self and non-Self, are also keys to understand the balance of this personality.
META-ANALYSIS: COMPARISON OF NEW PUBLIC SERVICES IN DEVELOPED AND DEVELOPING COUNTRIES
Authors: Lestari Linayati , Watu Arian Yunita Putri , Iskandar Muhammad , Hidayat Fendi , Wiyono Wiyono
Published: January 2025

This research aims to determine the development of new public services in developed and developing countries in the last six years. To find out, the author has reviewed hundreds of journals that discuss new public services in developed and developing countries with editions over the previous six years, namely from 2015 to 2021. Then, the author compares the concepts used in new public services in developed and developing countries. This research uses qualitative methods with a previous review. The data sources in the study are selected articles in the Scopus database in the last six years. Selected items are publications that are relevant to the topic of new public services in developed and developing countries. The results of this research were obtained through the data analysis process of VosViewer and Nvivo 12 plus software. The research results show that 56 concepts examine new public services in developed countries and categorize them into 8 clusters. Meanwhile, new public services in developing countries have 32 concepts and 1 Cluster. The relevance of this research is the discovery of a concept mapping of new public services in developed and developing countries to assist in developing a conceptual framework for further recent public service studies. Its novelty can be seen in other research
Green Jobs and Environmental Transition
Authors: Liptak Katalin
Published: January 2025

The concepts of the green labour market and green jobs can pertain to employment within a limited range of industries that offer environmental services. Nonetheless, it is more beneficial for policymakers to address the wider issue of how policies aimed at mitigating environmental externalities impact employment. Much of the literature focuses on direct job creation and only superficially addresses indirect job creation. The potential negative effects of green growth policies on labour productivity and employment costs are generally ignored. The methodology of the paper was a PRISMA systematic literature review (Preferred Reporting Items for Systematic reviews and Meta Analyses). In the future, more attention should also be paid to how labour markets function in different types of economies, especially in disadvantaged peripheral areas. Employment policy in Hungary is based on the jobs paradigm, i.e. the focus is on classical wage labour and job creation. Global trends suggest that there is likely to be a permanent imbalance between the number of wage jobs and the working-age population soon. For this reason, a sustainable and green labour market will become increasingly important in the future.
Generative AI, Disruptive Innovation, and Marketing Firm Strategies: Opportunities and Implications
Authors: AbouElgheit Emad
Published: January 2025

This study investigates the potential of small marketing firms to disrupt the market by adopting generative AI technology and the theory of disruptive innovation. The study employs a qualitative approach, combining a comprehensive literature review with in-depth interviews with leaders of small marketing firms. The research findings position generative and conversational AI as the next technological evolution, succeeding the internet and mobile/social era. It is the first study applying the theory of disruptive innovation to generative AI use in small marketing firms, presenting a positive outlook toward integrating generative AI into marketing operations. The study contributes to the emerging knowledge of AI in marketing, offering practical implications for scholars and practitioners to advance this field.
Green Waves: How Leaders’ Actions Shape Employee Behaviours, a Moderated Mediation Model of Organizational Green Culture and Personality Traits
Authors: Zheng Cheng , McKay Ruth , Ciocirlan Cristina
Published: January 2025

In the recent decade, the literature on corporate greening, sustainability, and environmental performance has burgeoned. Organizational citizenship behaviour for the environment (OCBE), defined as employees’ voluntary behaviours that aim to contribute to the organization’s environmental management, has recently attracted considerable scholarly attention. Through a holistic review and synthesis of the current literature on OCBE, we aim to bridge the gaps in the literature and provide new and novel insights into the cascading effect of leaders’ OCBE throughout the organization. Specifically, we delineate the link between leaders’ OCBE engagement and followers’ propensity to engage in OCBE, a link mediated by organizational green culture (OGC). In addition, given the lack of attention to intra-personal variables in the OCBE literature, we also aim to explain the moderating effect of personality in the proposed mediated relationship. Theoretically, from the social learning and social exchange lenses, the paper contributes to the current literature by explaining the interplay between interpersonal (leaders’ behaviour) and organizational (OGC) variables in predicting employees’ OCBE. We also highlight the role of the personality trait of openness to experience as a boundary condition that can affect employees’ propensity to perform high-intensity OCBE. From a practical perspective, this paper offers valuable insights for management and HR practitioners who are committed to effective environmental management and sustainability.
Escalation of Commitment and Bankruptcy: The Case of Katerra Industries
Authors: Brown Richard S.
Published: January 2025

Escalation of commitment has been defined as disregarding exit as a valid option thereby following a losing course of action even when the negative consequences are known. This paper incorporates escalation of commitment theory in the context of the failure of Katerra Industries. Katerra, backed with $3 Billion of venture capital, attempted to create a vertically integrated modular construction company based on its technological advantages. Instead, the firm expanded at a rate that made the complexity of its operations too difficult to manage properly leading to its Chapter 11 bankruptcy filing in June 2021. This paper employs qualitative empirical research, specifically through a case study utilizing U.S. federal court filings and testimony as the primary data source. The findings support previous escalation of commitment research, generally, and its theoretical underpinnings, namely (i) Subjective Expected Utility Theory and (ii) Self-Presentation Theory.
Change in Nurses’ Reactions to Psychosocial Work Environment Factors During the Accreditation Period
Authors: Reigas Viljaras , Šukienė Ingrida
Published: January 2025

In the modern healthcare system, significant focus is given to ensuring the quality of services, leading to the necessity of selecting the most suitable quality improvement measure for healthcare organizations. However, it has not been clear which quality improvement measure is the most appropriate for the healthcare services sector, as quality is understood and assessed differently in this field compared to other sectors. Various regulatory methods for healthcare service organizations are used worldwide, including licensing, accreditation, and certification. The application of quality assurance standards in healthcare organizations is based on the fact that these organizations seek to change their current practices to improve outcomes. Implementing each quality measure elicits certain reactions from healthcare professionals, which are not always favorable to the organization. This article examines the impact of accreditation on the changes in psychosocial work environment factors experienced by nurses during each accreditation phase.
Cinematic Mythmaking in Andrey Zvyagintsev's The Return and The Banishment
Authors: Mealing Louis Samuel
Published: January 2025

Since his debut feature The Return (2003), Andrey Zvyagintsev's films have drawn focus from film critics and theorists seeking to investigate a contextual analysis or the director's religious allusions. Hailed as the New Tarkovsky by some, a western-centric perspective has placed Zvyagintsev within the Russian canon from which he originates. However, in doing so, there has been a tendency to overlook a form and aesthetic that seeks to avoid these categorisations. By attempting to engage with his films independently from these frameworks and from a purely humanist perspective of subjectivity, the depth of Zvyagintsev's cinema comes to the surface. We find that the metaphysical reflections of Zvyagintsev's films relate not only to the cinema and its artificial worlds, but also to the position of the human in the real world. Independent of a prior historical or religious perspective, this metaphysical relationship to Zvyagintsev's films focuses on the human and the human consciousness. This article will engage with Zvyagintsev's first two features, The Return (2003) and The Banishment (2007), considering metaphysical aphorisms of one of Zvyagintsev's constant reference points, Georgian philosopher Merab Mamardashvili. This will allow us the opportunity to rethink the relations between cinematic form, the human and the consciousness.
Caries de la primera infancia. Visión de conjunto actualizada. Revisión narrativa de la literatura
Authors: Hernandez Miguel , Boj JR  , Muñoz Laura , Traver Carla , Yuste Silvia , Ortiz Reyes , Garcete Clara
Published: January 2025

Objective: The purpose of this literature review is to gather updated information on diagnostic and therapeutic guidelines for early childhood caries. Material and methods: PubMed, Embase, Ovid, Cochrane Central and Google Scholar were searched for appropriate articles up to 5 years old (up to January 2018 inclusive). 229 studies were identified, including 13 clinical trials that discussed different treatment modalities for teeth affected by this disease. Conclusion: Early childhood caries is an increasingly common disease and is a condition that presents a unique set of clinical challenges for dental health professionals. This updated information recommends starting treatment as early as possible to eliminate the risk of increased cavitations because of early childhood dental caries and its consequences in these patients.
Frecuencia de cepillado y uso de pasta dental con flúor en niños de 0 a 3 años de la parroquia hermano miguel del cantón cuenca
Authors: Lema Atiencie Angie Estefanía , Moscoso Abad María Elizabeth
Published: January 2025

Objective: Oral hygiene in children aged 0 to 3 years is essential to prevent dental caries and promote healthy habits. Materials and methods: This was a quantitative, descriptive, observational and cross-sectional study. The sample consisted of 240 children aged 0 to 3 years. The information was collected through a questionnaire validated and approved by experts in the area. This instrument consisted of 16 questions about affiliation, type of oral hygiene input, frequency of tooth brushing and type of toothpaste that the father uses on the child. Data was processed by the statistical software SPSS in its version 26. Results: TMost of the sample was made up of girls (51.7%). The most reported frequency of tooth brushing was twice a day (48.8%). The most used fluoride toothpaste is 1000-1100 PPM (35.8%). 40% of one-year-old children use the amount of toothpaste equivalent to 1 grain of raw rice. The most common daily brushing was twice a day (54.8%) in households with incomes below $400. Conclusion: Most of the children aged 0-3 years in the Hermano Miguel Parish brush their teeth twice a day and use fluoride toothpaste of 1000-1100 PPM. Conclusion: Giomer Beautifil II presented the highest surface hardness, while Tetric N-Ceram Bulk Fill resin achieved the highest compressive strength. Conversely, Alkasite Cention-N obtained the lowest values for both mechanical properties.
Recomendación del editor
Authors: Alvarez Vidigal Evelyn
Published: January 2025

Los materiales restauradores han evolucionado a lo largo del tiempo; así, cada vez más se utilizan los materiales bioactivos que, por su bioactividad buscan remplazar, reparar y regenerar tejido simulando mecanismos fisiológicos de remineralización, para obtener resultados eficientes y duraderos.
Quiste de erupción dental: Reporte de caso
Authors: Rocafuerte Acurio Marco Antonio
Published: January 2025

Eruption cysts are benign lesions of soft tissue that appear on the mucosa of tooth shortly before its eruption. These may go away on their own, but if thet hurt, bleed or become infected, thet may require surgical treatment to expose the tooth and drain its content. We will presenta a case of an eruption cyst at the level of pieces 5.5 and 6.5 whose treatment was surgical in order to expose the crowns of the teeth. The objective of this article is to present the most relevant aspects related to this developmental alteration in order to achieve a correct diagnosis and provide an adequate tretament.
Instrumentación con sistema rotatorio en pulpectomías de molares primarios: reporte de caso
Authors: Balvin Karina Ccoicca , Caldas Brigette Aguirre , Gutierrez Anali España , Nicaido Andrea Cadillo , Ramos Nadia Vicente
Published: January 2025

Objective: To describe the clinical performance of a rotary system with NiTi files in pulpectomies of primary molars over a 6-month period in terms of instrumentation, shaping, and obturation of root canals. Case Report: A 6-year-old female patient diagnosed with irreversible pulpitis in teeth 75 and 85 underwent pulpectomies using nickel-titanium (NiTi) rotary files for biomechanical preparation. The filling was performed with Endoflas FS paste. Then, two primary molars (75 and 85) were restored with preformed crowns. Clinical and radiographic controls performed at 3 and 6 months showed the absence of clinical signs such as pain or inflammation. Radiographically, adequate physiological resorption and stability of periapical tissues were observed. Conclusion: Instrumentation with rotary systems with NiTi files in pulpectomies of primary molars presented good clinical and radiographic performance in terms of instrumentation, conformation and obturation of root canals at 6 months of follow-up.
Decoding January 2025 Los Angeles Wildfires : How (and Why) the Emotional Power of Iconic Fires Revives Ancestral Fears and Fuels Misinformation
Authors: Gimello-Mesplomb Frédéric
Published: January 2025

The fires that ravaged Los Angeles in 2025 not only caused considerable material damage: they also triggered a parallel crisis of misinformation, fueled by the strong emotional and symbolic charge that fire carries in the collective imagination. Emblematic fires - whether the Great Fire of Rome (64 CE), the Great Fire of London (1666) or Notre-Dame Cathedral in 2019 - have acquired a metaphorical significance in human history that goes beyond their immediate context, highlighting profound social concerns. In Los Angeles, media coverage of the fires of 2025 intensified tensions around inequality, institutional failures and environmental justice, while the emotional dimension of the fire fostered the rapid rise of conspiracy theories. Fake news, such as the elite grabbing of resources, resonated with an American population already marked by distrust of institutions and its elites embodied by the billionaire duo Trump and Musk. What's more, the media's propensity to privilege emotional impact over factual information has only reinforced this phenomenon. To be truly effective, strategies to combat forest fire misinformation must therefore address both the emotional drivers of fire symbolism and the historical patterns that give these narratives their persuasive force. Concerted efforts by scientists (especially historians, sociologists and information and communication specialists), journalists and local players, combined with more factual communication, can help restore confidence and strengthen collective resilience. It seems essential to remember that fire in our civilization represents both an environmental threat and a powerful cultural symbol with deep-rooted roots and imagery, in order to better understand the dual crisis of fire-related ecological disasters and the misinformation that recurrently accompanies them.
User Satisfaction in Utilizing Collections at the University Library Board 17 August 1945 Surabaya
Authors: Eka Putri Selviyana Anggelina , Devi Katrin Setio
Published: January 2025

This research discusses the level of user satisfaction in utilizing collections at the University Library Board of 17 August 1945 Surabaya. The aim of this research is to determine the level of user satisfaction in utilizing the library's collections as stated in 10 statement items and distributed through a questionnaire. The method used in this research is quantitative using a sample size of 399 respondents. Data analysis in this research uses quantitative descriptive analysis. The results of this research show the level of user satisfaction obtained based on the results of the research and the value variables of 9 statement items containing the quality of the collection, suitability of the collection, completeness of the general collection, completeness of the reference collection, completeness of the scientific work collection, completeness of the serial collection, ease of finding the collection , the physical condition of the collection, the arrangement of the collection, as well as 1 indicator of user satisfaction related to the number of visits to the library, which shows the value of library user satisfaction with the collection owned by the UNTAG Surabaya Library Board, namely Very Good with the highest mean value of 3,60. So it can be concluded that the level of user satisfaction in utilizing the collections at the University Library Board of 17 August 1945 Surabaya is in the satisfied category.
Penetapan Kadar Flavonoid Total dan Nilai Sun Protection Factor (SPF) Fraksi Ekstrak Etanol Daun Sirih Muda (Piper betle L.)
Authors: Deviani Norma , Hakim Ali Rakhman , Ikeh Tri Sulapmi D. , Nastiti Kunti
Published: January 2025

Latar Belakang: Daun Sirih (Piper betle L.) merupakan tanaman yang banyak mengandung senyawa metabolit sekunder yang begitu penting salah satunya adalah golongan flavonoid. secara empiris di masyarakat khususnya di Kalimantan Selatan yang memanfaatkan daun tersebut sebagai campuran bedak dingin dengan menggunakan daun sirih yang masih muda sebagai pelindung terhadap sinar matahari.Tujuan: Mengetahui kadar flavonoid total fraksi ekstrak daun sirih muda (Piper betle L.) dan nilai sun protection factor (SPF) fraksi aquadest dan etil asetat.Metode: Metode Eksperimental dengan desain penelitian posttest only control group design dengan melihat hasil dari analisis kualitatif dengan kromatografi lapis tipis (KLT) dan analisis kuantitatif dengan spektrofotometri uv-vis untuk mengetahui nilai kadar flavonoid total flavonoid dan nilai sun protection factor (SPF) menggunakan metode Mansur.Hasil: Hasil Analisis kualitatif pada senyawa flavonoid dengan KLT menunjukkan hasil positif mengandung senyawa flavonoid. Pada analisis kuantitatif didapatkan kadar flavonoid total fraksi aquadest sebesar 14,4 mg EQ/g atau 1,44% dan fraksi etil asetat sebesar 16,4 mg EQ/g atau 1,64% dan nilai SPF tertinggi didapatkan pada fraksi etil asetat pada konsentrasi 600 ppm sebesar 17,29 dengan kategori proteksi ultra dan nilai SPF terendah terdapat pada fraksi aquadest konsentrasi 200 ppm sebesar 4,96 dengan kategori minimal.Simpulan: Fraksi ekstrak daun sirih muda dengan pelarut aquadest mengandung flavonoid total 14,4 mg EQ/g (1,44%), sedangkan fraksi etil asetat mengandung 16,4 mg EQ/g (1,64%). Nilai SPF tertinggi sebesar 17,29 (kategori proteksi ultra) ditemukan pada fraksi etil asetat dengan konsentrasi 600 ppm.
Evaluasi Penerapan Standar Pelayanan Kefarmasian Di Puskesmas Kecamatan Parenggean
Authors: Rahmah Aulia , Yuwindry Iwan , Komaliya Risyda
Published: January 2025

Latar Belakang: Sebagian daerah pedalaman sering kali menghadapi tantangan tersendiri dalam hal akses dan kualitas pelayanan kefarmasian, peran apoteker maupun tenaga kefarmasian di Puskesmas masih menjadi pertanyaan. Berdasarkan hal tersebut, peneliti sangat tertarik untuk mengetahui bagaimana penerapan pelayanan kefarmasian di Puskesmas di tempat asal peneliti yaitu Puskesmas di Kecamatan Parenggean.Tujuan: Penelitian ini bertujuan untuk Mengobservasi secara mendalam mengenai penerapan standar pelayanan kefarmasian di Puskesmas Parenggean I dan Puskesmas Parenggean II berdasarkan Permenkes RI nomor 74 tahun 2016 dan Permenkes RI nomor 26 tahun 2020Metode: Metode yang digunakan yaitu observasi dan wawancara mendalam yang dilakukan secara langsung kepada Apoteker dengan penyerahan lembar observasi yang berisi pertanyaan untuk mendapatkan informasi mengenai Pengelolaan Sediaan Farmasi dan Bahan Medis habis Pakai, Pelayanan Farmasi Klinik, Sumber Daya Manusia dan Sarana Prasarana.Hasil: Terdapat dua Puskesmas yang berada di Kecamatan Parenggean. Semua puskesmas telah menerapkan Pengelolaan Sediaan Farmasi dan Bahan Medis Habis Pakai sesuai dengan Permenkes nomor 74 tahun 2016, namun dalam aspek Pelayanan Farmasi Kinik belum sepenuhnya dilakukan seperti visite pasien karena di dua Puskesmas tersebut tidak memiliki ruang rawat inap.Simpulan: Pelayanan kefarmasian di Puskesmas Parenggean I mencapai 96% dan Puskesmas Parenggean II mencapai 100% sesuai dengan Permenkes nomor 74 tahun 2016 dan Permenkes nomor 26 tahun 2020. Nilai tersebut menunjukkan bahwa secara keseluruhan kedua Puskesmas telah sesuai standar dengan kategori baik dalam melakukan pelayanan kefarmasian di wilayah kerjanya
Analisis Pola Perilaku Self Care Pada Pasien Hipertensi Patuh Pengobatan Dengan Pendekatan Health Belief Model
Authors: Khairunisa Aisya Fitri , Yuwindry Iwan , Mukti Yusuf Anggoro , Syamsu Erlina
Published: January 2025

Latar Belakang: Angka prevalensi hipertensi yang terus mengalami peningkatan menjadi prioritas dalam bidang kesehatan global. Aspek utama dalam pengobatan hipertensi adalah kepatuhan pengobatan dan penanganan non farmakologis seperti self care dan health belief model. Namun, kesadaran masyarakat terhadap penanganan hipertensi tergolong masih rendah.Tujuan: Menganalisis pola perilaku self care pada pasien hipertensi dengan indikator patuh pengobatan dengan menerapkan pendekatan health belief model.Metode: Jenis peneltian yang digunakan adalah observasional analitik dengan rancangan cross sectional. Teknik pengambilan sampel purposive sampling. Sampel pada penelitian ini yaitu 45 responden yang terdiri dari  37 perempuan dan 8 laki-laki. Pengambilan data dilakukan dengan wawancara menggunakan kuesioner dan analisis dengan uji rank spearman dengan derajat kemaknaan (α) = 0.05.Hasil: Analisis bivariat didapatkan persepsi kerentanan (p value = 0.000; rho = 0,796), persepsi keparahan (p value = 0.000; rho = 0,858), persepsi manfaat (p value = 0.000; rho = 0,752), persepsi hambatan (p value = 0.000; rho = 0,747), isyarat untuk bertindak (p value = 0.000; rho = 0,781), efikasi diri (p value = 0.000; rho = 0,714), nilai dan sikap (p value = 0.000; rho = 0,726), dukungan sosial (p value = 0.000; rho = 0,593).Simpulan: Terdapat hubungan yang bermakna antara persepsi kerentanan, keparahan, manfaat, hambatan, isyarat untuk bertindak, efikasi diri, nilai dan sikap, dukungan sosial dalam perilaku pengendalian hipertensi dengan indikator patuh pada penderita hipertensi usia produktif (26-45 tahun) di wilayah kerja Puskesmas Sungai Tabuk 1
Penetapan Kadar Rhodamin B Pada Kerupuk Opak Bagula Di Kota Banjarmasin
Authors: Mawarid Muhammad Taufiq Fawwaz , Aryzki Saftia , Hidayah Nur , Rahmadani Rahmadani
Published: January 2025

Latar Belakang: Rhodamin B merupakan zat warna yang lazim digunakan pada industri tekstil dan kertas, sebagai pewarna kain, kosmetika, produk pembersih mulut, dan sabun. Zat kimia berbahaya ini sering disalahgunakan pada pembuatan makanan. Efek samping yang cukup serius apabila mengkonsumsi makanan yang mengandung rhodamin B seperti iritasi mata, iritasi kulit, kerusakan hati, kerusakan hati, mutagenik dan karsinogenik.Tujuan: Penelitian ini bertujuan untuk mengetahui keberadaan dan menganalisis kadar rhodamin B pada kerupuk opak bagula yang beredar di kota Banjarmasin.Metode: Metode yang digunakan pada penelitian ini adalah observasional analitik dengan rancangan Cross Sectional dan teknik pengambilan sampel menggunakan teknik purposive sampling.Hasil: Hasil analisis kualitatif pengijeksian larutan standar rhodamin B pada panjang gelombang 553 nm diperoleh waktu retensi 2,123 menit. Hasil menunjukan bahwa dari sampel (A), sampel (B), sampel (C) tersebut tidak mengandung rhodamin B ditandai dengan waktu retensi yang berbeda. Sementara itu, hasil analisis kuantitatif dengan instrumen HPLC menunjukkan tidak ada kadar rhodamin B yang terdeteksi pada semua sampel.Simpulan: Kerupuk opak yang beredar di kota Banjarmasin khususnya dijual di pasar ahad, siring dan taman kamboja dapat dinyatakan aman atau bisa untuk dikonsumsi
Pengaruh Konsentrasi Carbopol 940 dan Paraffin Liquid terhadap Evaluasi Sediaan Serum Emulgel Ekstrak Pegagan (Centella asiatica (L.) Urban) Sebagai Anti Jerawat
Authors: Kasmayuda Muhammad , Audina Mia , Mahdiyah Dede , Noval Noval
Published: January 2025

Latar Belakang: Jerawat merupakan salah satu masalah kesehatan pada kulit yang sering dialami setiap orang. Jerawat atau acne merupakan salah satu penyakit kulit yang umum terjadi diberbagai usia mulai dari remaja hingga dewasa. Pegagan (Centella asiatica  (L.) Urban) merupakan tumbuhan yang memiliki khasiat sebagai antibakteri untuk mengatasi bakteri penyebab jerawat. Serum emulgel adalah sediaan liquid yang memiliki bahan aktif berkonsentrasi tinggi dengan basis kombinasi antara emulsi dan gel.Tujuan: Mengidentifikasi formulasi variasi konsentrasi carbopol 940 dan paraffin liquid berdasarkan hasil evaluasi sediaan serum emulgel anti jerawat  ekstrak pegagan dan menganalisis pengaruh variasi konsentrasi carbopol 940 dan paraffin liquid terhadap evaluasi sediaan serum emulgel anti jerawat ekstrak pegagan.Metode: Metode penelitian yang digunakan adalah eksperimental dan rancangan penelitian yang dilakukan adalah dengan perlakuan atau intervensi yang kemudian melakukan desain quasi experimental design dengan rancangan Non-equivalent control group design dan one group posttest-only design.Hasil: Hasil penelitian menunjukkan sediaan serum emulgel ekstrak pegagan (Centella asiatica (L.) Urban) dengan variasi konsentrasi carbopol 940 dan paraffin liquid menunjukkan memiliki pengaruh terhadap organoleptik, pH, daya sebar, daya lekat, dan viskositas.Simpulan: Dari ketiga formula tersebut dalam pembuatan sediaan serum emulgel ekstrak pegagan dengan variasi konsentrasi carbopol 940 dan paraffin liquid dari hasil semua evaluasi fisikokimia didapatkan hasil yang terbaik pada formula 3.
Formulasi Dan Stabilitas Krim Kutu Air Ekstrak Rimpang Lengkuas (Alpina galanga L) Dengan Variasi Tween 80 Dan Span 60 Sebagai Emulgator
Authors: Maleh Arie , Budi Setia , Audina Mia , Noval Noval
Published: January 2025

Latar Belakang: Kutu Air merupakan penyakit infeksi yang disebabkan oleh jamur golongan dermatofita yang menginfeksi kulit pada bagian sela-sela jari kaki, telapak kaki dan bagian lateral kaki. Rimpang lengkuas (Alpinia galanga L) memiliki berbagai khasiat diantaranya sebagai antijamur. Krim adalah sediaan berbentuk setengah padat dan mengandung satu atau lebih zat obat yang terlarut atau terdistribusi menjadi basa. Krim memiliki sifat amfipatik yang memiliki bagian yang dapat melarutkan senyawa polar dan non polar. Sifat amfipatik tersebut terdapat pada emulgator pada sediaan krim. Emulgator Tween 80 dan span 60 termasuk kedalam emulgator golongan surfaktan yang dipilih karena tidak mengiritasi, dan tidak toksik.Tujuan: Mengetahui pengaruh variasi konsentrasi emulgator Tween 80 dan Span 60 terhadap evaluasi fisikokimia dan stabilitas sediaan krim kutu air ekstrak rimpang lengkuas.Metode: Metode yg digunakan adalah eksperimental dengan desain quasy experimental dengan rancangan penelitian pretest-posttest control group design.. Simplisia dibuat menjadi ekstrak kental, kemudian dibuat sediaan krim kutu air dan dilanjutkan dengan evaluasi fisikokimia dan stabilitas yang di percepat dengan metode cycling test. Data dianalisis menggunakan one way anova.Hasil: Hasil evaluasi sediaan krim kutu air ekstrak rimpang lengkuas dengan variasi tween 80 dan span 60 memenuhi syarat uji evaluasi dan stabilitas sediaan krim.Simpulan: Dari hasil evaluasi fisikokimia dan stabilitas sediaan krim kutu air ekstrak rimpang lengkuas yang telah semua formulasi memenuhi syarat uji sediaan krim
Formulasi Sediaan Lip Serum Minyak Argan (Argania spinosa L.) Dan Uji Efektivitas Sebagai Moisturizing Agent Secara In Vitro
Authors: Yandriyani Devilke
Published: January 2025

Latar belakang:  Masalah bibir kering dan pecah-pecah sering dialami oleh wanita. Hal ini disebabkan karena kurangnya nutrisi dan perawatan pada bibir sehingga perlunya produk kosmetik yang dapat digunakan untuk tujuan melembabkan dan menutrisi bibir dari luar dan dalam. Minyak argan merupakan salah satu bahan alam yang memiliki potensi sebagai Moisturizing Agent yang dapat diformulasikan menjadi sediaan Lip Serum yang dapat melembabkan dan menutrisi bibir. Penelitian ini bertujuan untuk mengetahui formula dan konsentrasi minyak argan yang paling optimal dan memiliki efektivitas sebagai Moisturizing Agent.Tujuan: Mengetahui efektivitas sediaan lip serum minyak argan sebagai moisturizing agent secara in vitro.Metode: Metode yang digunakan adalah true experiment menggunakan uji Sorption Desorption Test (SDT) dan dianalisis menggunakan uji Anova satu arah dengan p-value <0,05.  Formula sediaan lip serum dirancang menggunakan 5 formula dengan konsentrasi minyak argan yang berbeda-beda yaitu 0%, 15%, 20%, 25%, dan 30%.Hasil: Nilai efektivitas dihitung dengan nilai [AUC] total yang ditetapkan terhadap jumlah berat yang hilang pada saat penyimpanan. Semakin kecil berat yang hilang sehingga efektivitas kelembapannya semakin besar, begitu pula kebalikannya. Hasil pengamatan uji efektivitas pada sediaan lip serum minyak argan dengan konsentrasi 30% memiliki penurunan berat paling kecil dan nilai [AUC] total paling tinggi. Berdasarkan hasil uji statistik menunjukkan bahwa terdapat perbedaan yang signifikan dengan nilai p-value 1,5938E-08 (p-value < 0,05).Simpulan: Pada penelitian ini terdapat perbedaan efektivitas kelembaban 5 (lima) formula yang signifikan. Sediaan lip serum minyak argan dengan konsentrasi 30% memiliki kemampuan melembabkan (moisturizing agent) paling baik.
Studi Pengaruh Konsentrasi Pada Membran Selulosa Tandan Kosong Kelapa Sawit Terhadap Penurunan Kadar Kreatinin
Authors: Rahmawati  , Nur Hidayah  , Dede Mahdiyah  , Rahmadani
Published: January 2025

Latar belakang: Salah satu kendala utama dalam pengembangan membran dialisis adalah bahan baku polimer yang merupakan bahan baku utama dalam fabrikasi membran, salah satu cara mengatasi kendala tersebut adalah dengan mengembangkan dan memanfaatkan polimer alam berupa selulosa tandan kosong kelapa sawit.Tujuan: Melihat pengaruh konsentrasi selulosa pada membran selulosa tandan kosong kelapa sawit terhadap penurunan kadar kreatinin.Metode: Penelitian ini menggunakan metode true eksperimental dengan menggunakan instrumen Forier Transform Infra Red (FTIR) dan spektrofotometri UV-Vis.Hasil: Selulosa TKKS dilakukan uji FTIR menunjukkan adanya gugus C=C pada gelombang 1525, gugus -CH pada gelombang 2920 dan -OH pada gelombang 3423. Hasil kadar kreatinin setelah melalui filtrasi membran selulosa F1 siklus ke-1 0,519 mg/dl, siklus ke-2 0,513 mg/dl, siklus-3 0,506 mg/dl, dan siklus ke-4 0,5 mg/dl. Pada membran selulosa TKKS F2, siklus ke-1 0,495 mg/dl, siklus ke-2 0,445 mg/dl, siklus ke-3 0,354 mg/dl, dan siklus ke-4 0,325 mg/dl. Sedangkan membran selulosa TKKS F3, siklus ke-1 0,277 mg/dl, siklus ke-2 0,212 mg/dl, siklus ke-3 0,194 mg/dl, dan siklus ke-4 0,163 mg/dl. Pengolahan data uji Kruskal-Wallis menunjukkan nilai signifikansi (Asymp. Sig.) sebesar 0,007.Simpulan: Terdapat pengaruh konsentrasi selulosa pada membran terhadap penurunan kadar kreatinin secara signifikan
Deciphering the role of IL17RA in psoriasis and chronic mucocutaneous candidiasis: shared pathways and distinct manifestations
Authors: Kadhi Ayat , Eid Edward , Massaad Michel J. , El-Rassy Inaam , Khoury Dana Maria , Shimomura Yutaka , Rubeiz Nelly , Kurban Mazen , Nemer Georges
Published: January 2025

Introduction

Psoriasis and chronic mucocutaneous candidiasis (CMC), although distinct in their clinical manifestations, often coexist within specific patient cohorts. Despite this intriguing clinical observation, their genetic etiologies have been studied separately, neglecting the shared inflammatory mediator, interleukin 17A-F (IL17A-F). Consequently, the immunogenetic foundations underlying these conditions have remained enigmatic.

Methods

In this study, we analyzed the case of a 5-year-old female born to consanguineous parents who presented with concomitant psoriasis and CMC phenotypes. Utilizing whole exome and transcriptomic sequencing, we meticulously investigated the genetic underpinnings and molecular pathways underlying these complex pathologies. RNA sequencing was performed on a skin biopsy to confirm transcriptomic profiles associated with these conditions.

Results

We identified a novel bi-allelic variant (NM_014339.6, c.1173C>G A) within the interleukin 17 receptor type A (IL17RA) gene, resulting in a premature stop codon (p. Tyr391Ter). Despite the truncation, our investigations revealed that this variant produces a fully functional IL17RA protein. This was evident from the presence of IL17RA in the patient’s peripheral blood mononuclear cells (PBMCs) and the ability of the mutant IL17RA to dimerize with both wild-type protein and its partners IL17RC and IL17RD. Transcriptomic analysis of the skin biopsy showed a distinct psoriasis-associated signature intertwined with inflammatory pathways, including responses to fungal infections.

Discussion

This report unveils an unprecedented genetic link serving as a common denominator for psoriasis and CMC. The novel IL17RA variant highlights the pivotal role of this receptor in the shared inflammatory pathways underlying these conditions. Our findings bridge a critical knowledge gap and provide insights into the molecular mechanisms connecting these diseases. This discovery not only advances our understanding of their pathophysiology but also lays the groundwork for personalized therapeutic strategies, heralding a new era of precision medicine for patients with intertwined psoriasis and CMC.
Transcriptome analysis of Colletotrichum nymphaeae-Strawberry interaction reveals in planta expressed genes associated with virulence
Authors: Ozbudak Egem , Carrillo-Tarazona Yisel , Diaz Edinson A. , Zambon Flavia T. , Rossi Lorenzo , Peres Natalia A. , Raffaele Sylvain , Cano Liliana M.
Published: January 2025

Colletotrichum nymphaeae, the causal agent of anthracnose fruit rot, is globally recognized as a major pathogen of strawberries due to its economic impact. Fungal pathogens utilize secreted proteins to facilitate infection by acquiring host nutrients and suppressing plant immunity. Understanding the transcriptomic responses of C. nymphaeae during infection can provide critical insights into its pathogenic mechanisms. In this study, RNA sequencing (RNA-seq) was performed to profile the transcriptome of C. nymphaeae strain 02-179 during infection of leaf and fruit tissues of the susceptible strawberry (Fragaria x ananassa) cultivar Florida Beauty. Differential gene expression analysis identified fungal genes upregulated during these interactions. Transcriptomic profiling revealed a set of genes encoding secreted effector proteins, including NUDIX hydrolase and LysM domain-containing proteins. Additionally, genes associated with Carbohydrate-Active enzymes (CAZymes), such as multicopper oxidase, pectinesterase, pectate lyase, glycosyl hydrolase family 7, and endochitinase, were significantly upregulated. Notably, two novel tannase genes were identified among the top upregulated genes in strawberry-infected leaves and fruits. Tannase enzymes are hypothesized to degrade tannins, a group of plant secondary metabolites abundant in strawberries, known for their defensive roles against pests and pathogens. The identification of tannase genes and the other genes associated with virulence underscores the complex molecular strategies employed by C. nymphaeae to infect and colonize strawberry tissues. Genes involved in degrading plant cell walls, suppressing host defenses, and potentially overcoming chemical barriers such as tannins play critical roles in the pathogenesis of anthracnose. Further functional characterization of these genes will enhance our understanding of the disease mechanisms and could inform the development of improved management strategies for C. nymphaeae infections in strawberries.
Compliance Control of a Cable-Driven Space Manipulator Based on Force–Position Hybrid Drive Mode
Authors: Xiang Runhui , Xu Hejie , Li Xinliang , Zhu Xiaojun , Meng Deshan , Xu Wenfu
Published: January 2025

Multi-cable cooperative control is essential for cable-driven space manipulators to achieve in-orbit services such as fault spacecraft maintenance, fuel injection, on-orbit assembly, and orbital garbage removal. To prevent the cables from becoming slack or excessively tight, the force in each cable must be distributed appropriately. The force distribution among different cables requires real-time adjustments; otherwise, the system may become unstable. This paper proposes a compliance control method based on the force–position hybrid drive mode to address the challenges of multi-cable cooperative control. Firstly, the mapping relationship between the cable space and the joint space of the cable-driven space manipulator is established. Then, the force mapping relationship for this structure is derived. The control scheme categorizes the cables into two types: active-side cables and antagonistic-side cables. Position control and force control are implemented separately, significantly reducing the computational requirements and enhancing the overall performance of the control system. Finally, the feasibility of the proposed algorithm is demonstrated through simulations and compared with the PID control method. When tracking the same trajectory, the proposed method reduces the tracking error by 49.14% and the maximum force by 58.58% compared to the PID control method, effectively addressing the problem of force distribution in multi-rope coordinated control.
Rutting Caused by Grouser Wheel of Planetary Rover in Single-Wheel Testbed: LiDAR Topographic Scanning and Analysis
Authors: Takehana Keisuke , Ares Vinicius Emanoel , Santra Shreya , Uno Kentaro , Rohmer Eric , Yoshida Kazuya
Published: January 2025

This paper presents datasets and analyses of 3D LiDAR scans capturing the rutting behavior of a rover wheel in a single-wheel terramechanics testbed. The data were acquired using a LiDAR sensor to record the terrain deformation caused by the wheel’s passage through a Toyoura sandbed, which mimics lunar regolith. Vertical loads of 25 N, 40 N, and 65 N were applied to study how rutting patterns change, focusing on rut amplitude, height, and inclination. This study emphasizes the extraction and processing of terrain profiles from noisy point cloud data, using methods like curve fitting and moving averages to capture the ruts’ geometric characteristics. A sine wave model, adjusted for translation, scaling, and inclination, was fitted to describe the wheel-induced wave-like patterns. It was found that the mean height of the terrain increases after the grouser wheel passes over it, forming ruts that slope downward, likely due to the transition from static to dynamic sinkage. Both the rut depth at the end of the wheel’s path and the incline increased with larger loads. These findings contribute to understanding wheel–terrain interactions and provide a reference for validating and calibrating models and simulations. The dataset from this study is made available to the scientific community.
Using Machine Learning for Aerostructure Surface Damage Digital Reconstruction
Authors: Wu Yijia , Tang Hon Ping , Mannion Anthony , Voyle Robert , Xin Ying
Published: January 2025

Aerostructure surface damage inspection is carried out over the whole life-cycle using legacy processes and recording during maintenance. The inspection techniques record the detailed history of the damage and repair. However it remains elusive to predict the location of future damage on the aerostructure surface. In this paper, we work up a novel simulation technique based on the results of machine learning analysis for prediction of the reference location of future aerostructure surface damage. First, we use the support vector machine (SVM) and k-nearest neighbor (KNN) to analyze the damage on three B777-200 aircraft and find that the classification accuracy can range from 75.1% to 86%. Then, we use the prediction result of a feedforward neural network (FNN) to simulate the damage structure and the mapping relationship to explore its reconstructive possibility. We show that the aerostructure surface damage can be reconstructed by machine learning. Moreover, the aerostructure surface damage heat map obtained by reconstruction can be prepared for further image recognition analysis in the future.
Genome-Wide Analyses Reveal the Roles of CCT Genes as Regulators of Abiotic Stress Responses in Citrullus lanatus
Authors: Hong Yajie , Li Mengsha , Ding Wona , Shi Jun , Zheng Zishuo , Xing Nailin , Li Qiuping
Published: January 2025

Members of the CCT gene family have been shown to play roles in photoperiodic flowering and environmental adaptation under a range of conditions. In this study, 29 CCT genes from watermelon were categorized into three distinct subfamilies. The ClCCT genes were systematically analyzed, focusing on their physicochemical properties, gene duplication, motifs, structural divergence, promoter regions, and collinearity with genes from other species. The responsiveness of these genes to abiotic stressors, hormone treatments, and photoperiod prolongation was also examined. Segmental duplication (gene amplification) significantly influenced the evolution of these genes, with most ClCCT genes containing light-, hormone-, and/or abiotic stimulus-responsive elements. In response to abiotic and hormonal stresses, 5 genes responded to cold, 1 gene to drought, and 4 genes to salt. 6 genes were responsive to ABA, and 13 genes to MeJA. Strikingly, ClCCT17, ClCCT4, and ClCCT28 responded to multiple stressors. A majority of these ClCCT genes and their homologs in other species were responsive to prolonged daylight exposure. The varying expression patterns of these genes suggested a key role for watermelon CCT genes in the regulation of both abiotic stress responses and flowering. Functional diversity was also evident among CCT family genes within a given species as well as among species attributable to changes in the structural features and expression patterns of the genes and the encoded proteins.