bluuebunny/crossref_metadata_2025 huggingface dataset:
Fibrinogen-like protein 2 prothrombinase is localized in platelets
Authors: Cherny Izhack , Hasin Pinhas , Philosoph Liatl Kalich , Shahal-Zimra Yael , Rabizadeh Esther
Published: July 2022

Background: Fibrinogen-like protein 2 (FGL2) is a serine protease capable of converting prothrombin into thrombin (i.e., prothrombinase activity) while bypassing the classic coagulation cascade. It has been reported to be expressed by mononuclear blood cells and endothelial cells. There are multiple reports that FGL2 supports tumor development and metastasis. However, in the blood, the origin or functional significance has not been established.Objective: To identify the origin of the FGL2 prothrombinase, a malignancy related enzyme, in peripheral blood cells.Methods: Peripheral blood samples were collected in complete blood count tubes. Blood cells and platelets were thoroughly washed to produce plasma-free samples. Procoagulant activity was measured in the samples' extracts using a thrombin generation test or an adjusted prothrombin time (PT) test in plasma deficient factor X. Results were further supported by confocal microscopy, immunoprecipitation, flow cytometry, enzyme-linked immunosorbent assays and specific inhibition assays. Results: The pro-coagulant activity of FGL2 was detected in purified platelets but not in white blood cells. FGL2 protein was readily detected in platelets. Quiescent platelets were shown to store FGL2 protein in an active form. Upon activation, platelets secreted the active FGL2 into the milieu. Conclusions: Active FGL2 prothrombinase is stored in platelets. This suggests the involvement of platelets in malignancies.
Comparative efficacy of ivermectin and fenbendazole against ancylostomiasis in dogs
Authors: Bhanjadeo Rojali Chandra , Patra Ramesh Chandra , Panda Dibya , Das Debiprasanna
Published: July 2022

The present experiment was carried ut to assess the comparative efficacy of ivermectin and fenbendazole individually for anthelmintic therapy for the hookworm infested dogs. Dogs presented to the Department of Veterinary Clinical Medicine or Veterinary Clinical Complex, Bhubaneswar were randomly screened for Ancylostoma caninum infection and the positive dogs were selected for the therapeutic trial Faecal samples were collected randomly from presented dogs immediately after defaecation or from the rectum directly using a faecal scoop. The collected sample was examined by floatation technique to detect the positive cases of Ancylostoma caninum infection. The dogs with normal clinical parameters and no eggs or ova in the faeces were included in in group 1 (n=12). Dogs with faecal sample positive for Ancylostoma caninum ova were recruited for the comparative study (n=24) which were grouped into two groups consisting of 12 dogs in each (group 2 and 3). Group 2 dogs (n=12) were treated with ivermectin at 200 µg/kg body weight once orally repeated after 15 days with proper supportive therapy each time. Group 3 (n=12) were treated with fenbendazole at 50 mg/kg body weight once orally repeated after 15 days with proper supportive therapy each time.Haematological examinations and serum biochemical tests were carried out in all groups each time on day 0, 15 and 30 of the experiment. The therapeutic efficacy of both the drugs was calculated on the basis of number of animals found free of Ancylostoma infection as determined by faecal sample examination and reduction in EPG count of the faeces of the group following the treatment. The reduction in eggs per gram (EPG) count on day 15 and day 30 was more significant in group 2 than group 3. The mean EPG count in fenbendazole-treated dogs reduced significantly to 24.17 + 11.44 on day 15 from day 0 level of 1650.00 + 247.25. The value again reduced from day 0 to become nil on day 30 .The 15th day after treatment, mean ± SE values of protein, albumin and globulin were changed to 5.63 ± 0.12, 2.64 ± 0.12 and 2.99 ± 0.15 g/dl, respectively. The 30th day after treatment the values were 6.23 ± 0.14, 3.20 ± 0.18 and 3.03 ± 0.21 g/dl, respectively. The total protein and albumin values were significantly changed by 15th day and 30th day at 1% level of significance as compared to that of day 0 in group 2 and 3 respectively.Following treatment with ivermectin, the 15th day haematological values increased significantly at 1% level (P<0.01) of significance. There was significant increase in the values at 1% level on the 30th day compared to day 0. The mean values were non-significantly comparable to the healthy control group except PCV and TEC on the 30th day.
Formation of subcellular compartments by condensation-prone protein OsJAZ2 in Oryza sativa and Nicotiana benthamiana leaf cells
Authors: Koja Yoshito , Joshima Yu , Yoritaka Yusuke , Arakawa Takuya , Go Haruka , Hakamata Nagisa , Kaseda Hinako , Hattori Tsukaho , Takeda Shin
Published: July 2022

Eukaryotic cells contain various membrane-less organelles, which are compartments consisting of proteinaceous condensates formed by phase separation. Such compartments are attractive for bioengineering and synthetic biology, because they can modify cellular function by the enrichment of molecules of interest and providing an orthogonal reaction system. This study reports that Oryza sativa JAZ2 protein (OsJAZ2) is an atypical jasmonate signalling regulator that can form large condensates in both the nucleus and cytosol of O. sativa cells. TIFY and Jas domains and low-complexity regions contribute to JAZ2 condensation, possibly by multivalent interaction, thus forming gel-like or solid compartments. Moreover, JAZ2 can also form liquid-like condensates when expressed in Nicotiana benthamiana cells. The recombinant JAZ2 fused to the green fluorescent protein (GFP) forms condensate in vitro, suggesting that the intermolecular interaction of JAZ2 molecules is a driving force for condensation. These results suggest the potential use of JAZ2 condensates to construct artificial membrane-less organelles in plant cells.
Impact of Rural Out-Migration on Technical Efficiency of Wheat and Teff Producers in Southern Ethiopia
Authors: Eshetu Fassil , Haji Jema , Ketema Mengistu , Mehare Abule
Published: July 2022

This study examined the impact of rural out-migration on the technical efficiency of producers using the new economics labor migration theory as a theoretical framework, and the multinomial endogenous switching regression as an analytical framework. Primary data were gathered from a random sample of 415 rural households in southern Ethiopia. Descriptive results showed that most of the migrants are young, better educated, unmarried, and male migrants. The mean technical efficiency of wheat and teff are 83 and 66 percent respectively. The average treatment effect on treated and untreated are − 5.51 and − 4.14 respectively for teff producers, and significant at 1 percent. The base heterogeneities for participation in rural-urban migration are 4.10 and 3.09 for wheat and teff producers respectively whereas the base heterogeneities for participation in international migration are 12.85 and 14.24 for wheat and teff producers respectively. Besides, the base heterogeneities for non-participation in international migration are 14.6 and 21.25 for wheat and teff producers respectively. Hence, rural out-migration significantly reduces crop technical efficiency, and the finding supports the lost labor hypothesis of the new economics labor migration theory. Promoting productivity, off-farm activity, and provision of public goods would reduce labor out-migration in southern Ethiopia.
Does digital financial inclusion reduce the risk of returning to poverty? Evidence from China Does digital financial inclusion reduce the risk of returning to poverty? Evidence from China
Authors: Xu Fang , Zhang Xiaoru , Zhou Di
Published: July 2022

Digital financial inclusion has become an important way to reduce poverty and prevent poverty return; however, few studies examine the relationship between digital financial inclusion measurement with poverty return governance. Based on data from the 2017 China Household Financial Survey, we construct a digital financial inclusion indicator for micro-households, and explore its impact on the risk of households returning to poverty and its mechanism of action. Our findings suggest that digital financial inclusion can reduce the risk of Chinese families returning to poverty, and that it has heterogeneous effects on families and regions with different characteristics. The main function is to improve household income level by promoting entrepreneurship and employment, and to improve risk resistance by enhancing household financial market participation and household asset allocation. Further analysis shows that digital financial inclusion has structural effects, nonlinear effects, and substitution effects with private lending in poverty governance. This paper has implications for understanding and improving the poverty governance effectiveness of digital financial inclusion.
Technological changes in the glazed wares of northern Tunisia in the transition from Fatimid to Zirid rule
Authors: Salinas Elena , Reynolds Paul , Pradell Trinitat
Published: July 2022

A representative selection of glazed ceramics recovered from medieval Islamic contexts excavated in the former Roman port of Utica (North Tunisia) has revealed new data about medieval glaze technologies in the central Mediterranean. Stratified sequences of pottery have established four main phases of occupation which span the mid-10th to the mid-11th centuries. The Utica assemblage demonstrates significant changes in the range of glazed wares in the Zirid period with respect to the late Fatimid period: whereas polychrome yellow-amber glazed ware, produced in the Kairouan region, was practically the only glazed ware supplied to Utica in the Fatimid period, an increasingly varied range of polychrome glazed wares was produced in various techniques in the late 10th century, early Zirid period. These new glazed ware types become dominant in the early 11th century. Up to six different glazing techniques have been identified, including transparent and opaque glazes with underglaze and overglaze decoration respectively. The absence of tin in all the glazed vessels sampled from Utica confirms the data obtained in a previous study from Bir Ftouha. Though it has been repeatedly stated that tin was used to produce the white background of Fatimid-Zirid glazed wares in Tunisia, this was achieved by adding quartz to the glaze. Some imports of glazed ceramics from Sicily and al-Andalus have been detected: their appearance in the early-mid 11th century is significant as seems to indicate a first stage in the re-activation of Mediterranean commerce, which increased in the course of the following centuries.
Histopathological features have limited correlation with gene expression-based classifiers
Authors: de Weerd Simone van , Smit Marloes , Roelands Jessica , Mesker Wilma , Bedognetti Davide , Kuppen Peter , Putter Hein , Tollenaar Rob , Roodhart Jeanine , Hendrickx Wouter , Medema Jan Paul , Krieken Han van
Published: July 2022

The purpose of this study was to evaluate the association between four distinct histopathological features, (1) tumor infiltrating lymphocytes, (2) mucinous differentiation, (3) tumor-stroma ratio, (4) tumor budding and two gene expression-based classifiers, (1) consensus molecular subtypes (CMS), (2) colorectal cancer intrinsic subtypes (CRIS). All four histopathological features were retrospectively scored on hematoxylin and eosin-stained sections of the most invasive part of the primary tumor of 218 stage II and III colon cancer patients from two independent cohorts (AMC-AJCC-90 and AC-ICAM). RNA-based CMS and CRIS assignments were independently obtained for all patients. Contingency tables were constructed and χ2 test was used to test for statistical significance. Odds ratios with 95% confidence intervals were calculated. The presence of tumor infiltrating lymphocytes and a mucinous phenotype (>50% mucinous surface area) were positively correlated with CMS1 (p < 0.001 and p = 0.008) and CRIS-A (p = 0.006 and p < 0.001). The presence of mucus (≥ 10%) was strongly associated with CMS3: mucus was present in 64.1% of all CMS3 tumors. Although a strong association between tumor-stroma ratio and CMS4 was established in this study (p = 0.006), still 32 out of 61 (52.5%) CMS4 tumors were scored as stroma-low, indicating that CMS4 tumors cannot be identified solely based on stromal content. Higher budding counts were seen in CMS4 and CRIS-B tumors (p = 0.045 and p = 0.046). No other associations of the measured parameters were seen for any of the other CRIS-subtypes. Our analysis revealed that histopathologic features have limited correlation with CMS and CRIS subtypes. Identification of distinct molecular subtypes using histopathology alone proved to be infeasible. Our findings also indicate that histopathologic features and molecular subtypes should be seen as distinct biomarkers. Combining both molecular and morphologic features could potentially improve patient stratification.
Impact of high-grade patterns in early-stage lung adenocarcinoma: a multicentric analysis
Authors: Bertoglio Pietro , Aprile Vittorio , Ventura Luigi , Cattoni Maria Angela , Nachira Dania , Lococo Filippo , Perez Maria Rodriguez , Guerrera Francesco , Minervini Fabrizio , Querzoli Giulia , Bocchialini Giovanni , Bacchin Diana , Franzi Francesca , Rindi Guido , Bellafiore Salvatore , Femia Federico , Bogina Giuseppe Salvatore , Solli Piergiorgio , Kestenholz Peter , Ruffini Enrico , Paci Massimiliano , Margaritora Stefano , Imperatori Andrea Selenito , Lucchi Marco , Gnetti Letizia , Terzi Alberto Claudio
Published: July 2022

ObjectiveThe presence of micropapillary and solid adenocarcinoma patterns leads to a worse survival and a significantly higher tendency to recur. This study aims to assess the impact of pT descriptor combined with the presence of high-grade components on long-term outcomes in early-stage lung adenocarcinomas.MethodsWe retrospectively collected data of consecutive resected pT1-T3N0 lung adenocarcinoma from nine European Thoracic Centers. All patients who underwent a radical resection with lymph node dissection between 2014 and 2017 were included. Differences in Overall Survival (OS) and Disease-Free Survival (DFS) and possible prognostic factors associated with outcomes were evaluated also after performing a propensity score matching to compare tumors containing non-high-grade and high-grade patterns.ResultsAmong 607 patients, the majority were male and received a lobectomy. At least one high-grade histological pattern was seen in 230 cases (37.9%), of which 169 solid and 75 micropapillary. T1a-b-c without high-grade pattern had a significant better prognosis compared to T1a-b-c with high-grade pattern (p=0.020), but the latter had similar OS compared to T2a (p=0.277). Concurrently, T1a-b-c without micropapillary or solid patterns had a significantly better DFS compared to those with high-grade patterns (p=0.034), and it was similar to T2a (p=0.839). Multivariable analysis confirms the role of T descriptor according to high-grade pattern both for OS (p=0.024; HR 1.285 95% CI 1.033-1.599) and DFS (p=0.003; HR 1.196, 95% CI 1.054-1.344 respectively). These results were confirmed after the propensity score matching analysis.ConclusionspT1 lung adenocarcinomas with a high-grade component have similar prognosis of pT2a tumors.
Degree of dietary specialization on furanocoumarin-containing hostplants in a newly invasive species, Depressaria depressana (Lepidoptera: Depressariidae)
Authors: Dean Charles-Antoine Edouard , Katz Aron , Wu Wen-Yen , Berenbaum May R.
Published: July 2022

The genus Depressaria (Lepidoptera: Depressariidae) mostly comprises specialist herbivores with varying capacity for detoxification of defensive phytochemistry. Depressaria depressana , a Eurasian moth recently introduced into North America, is a family-level specialist of the Apiaceae, whose hosts include more than a dozen species in multiple tribes; Depressaria radiella is a family specialist of Eurasian origin that feeds almost exclusively on species in the genera Pastinaca and Heracleum throughout its native and introduced range. In eastern North America it is found almost exclusively on Pastinaca sativa , an invasive European species, and Heracleum maximum , a native species. We determined whether differences in furanocoumarin metabolism exist between D. depressana and two isolated populations of D. radiella, feeding exclusively on either P. sativa or H. maximum . We also compared gravimetric estimates of efficiency to assess D. depressana larval performance on different diets. Both populations of D. radiella metabolized furanocoumarins at a greater rate than D. depressana . Although there was no difference in rates of metabolism of linear furanocoumarins in the two populations of D. radiella , individuals collected from H. maximum metabolized angular furanocoumarins more rapidly. The gravimetric assessments of performance revealed that D. depressana exhibited highest efficiencies consuming D. carota ; moreover, this species could survive consuming fruits of Z. aurea , an apiaceous species native to North America. Our preliminary phylogenetic analysis, building on an earlier morphological analysis, incorporates the mitochondrial cytochrome oxidase subunit 1 data, and revealed that the presence or absence of furanocoumarins is not a strong predictor of species-level evolution in Depressaria .
Sensory descriptors for three edible Chilean seaweeds and their relations to umami components and instrumental texture
Authors: Figueroa Valentina , Bunger Andrea , Ortiz Jaime , Aguilera José Miguel
Published: July 2022

Although seaweeds exhibit many benefits as a food source, few studies have characterized their sensory attributes. An expert nine-member panel developed a vocabulary with 25 descriptors to describe the appearance, aroma, flavor, texture, and aftertaste of raw and cooked seaweeds consumed in Chile: Durvillaea antarctica, Pyropia spp., and Ulva lactuca. Subsequently, the vocabulary was used in a ranking descriptive analysis (RDA) to evaluate the sensorial properties and relate them with physicochemical and physical data. Sensory attributes of the three seaweeds were very different from each other but similar between treatments (raw and cooked). Pyropia spp., both cooked and hydrated, had the highest glutamate content (310 and 324 mg/100g d.w., respectively), and was perceived by the sensory panel as having the most umami taste. Cooked D. antarctica was perceived as sweeter, had more caramel notes than the hydrated seaweed and was sensed as cartilaginous and hard in accordance with its mechanical properties. Generalized Procrustes Analysis revealed that D. antarctica exhibited most of the desirable descriptors, such as caramel, umami and marine aromas while U. lactuca was described as bitter and moldy. This primary vocabulary can assist food scientists and chefs in the development of seaweed products and dishes for the consumer market.
Omentin ameliorates myocardial ischemia-induced heart failure via SIRT3/FOXO3a-dependent mitochondrial dynamical homeostasis and mitophagy
Authors: Hu Jingui , Liu Tao , Fu Fei , Cui Zekun , Lai Qiong , Zhang Yuanyuan , Yu Boyang , Liu Fuming , Kou Junping , Li Fang
Published: July 2022

Background
Adipose tissue-derived adipokines are involved in various cross-talk between adipose tissue and other organs. Omentin, a novel adipokine, exerts vital roles in the maintenance of body metabolism, insulin resistance and the like. However, the protective effect of omentin in myocardial ischemia (MI)-induced heart failure (HF) and its specific mechanism remains unclear and to be elucidated.
Methods
The model of MI-induced HF mice and oxygen glucose deprivation (OGD)-injured cardiomyocytes were performed. Mice with overexpression of omentin were constructed by a fat-specific adeno-associated virus (AAV) vector system.
Results
We demonstrated that circulating omentin level diminished in HF patients compared with healthy subjects. Furthermore, the fat-specific overexpression of omentin ameliorated cardiac function, cardiac hypertrophy, infarct size and cardiac pathological features, and also enhanced SIRT3/FOXO3a signaling in HF mice. Additionally, administration with AAV-omentin increased mitochondrial fusion and decreased mitochondrial fission in HF mice, as evidenced by up-regulated expression of Mfn2 and OPA1, and downregulation of p-Drp1(Ser616). Then, it also promoted PINK1/Parkin-dependent mitophagy. Simultaneously, treatment with recombinant omentin strengthened OGD-injured cardiomyocytes viability, restrained LDH release, and enhanced the mitochondrial accumulation of SIRT3 and nucleus transduction of FOXO3a. Besides, omentin also ameliorated unbalanced mitochondrial fusion-fission dynamics and activated mitophagy, thereby, improving the damaged mitochondria morphology and controlling mitochondrial quality in OGD-injured cardiomyocytes. Interestingly, SIRT3 played an important role in the improvement effects of omentin on mitochondrial function, unbalanced mitochondrial fusion-fission dynamics, and mitophagy.
Conclusion
omentin improves MI-induced HF and myocardial injury by maintaining mitochondrial dynamical homeostasis and activating mitophagy via upregulation of SIRT3/FOXO3a signaling. This study provides evidence for further application of omentin in cardiovascular diseases from the perspective of cross-talk between heart and adipose tissue.
Data-driven Modelling of Engineering Systems with Small Data, a Comparative Study
Authors: Mohammadzaheri Morteza , Soltani Payam , Ziaeifar Hamidreza , Bahadur Issam , Zarog Musaab , Emadi Mohammadreza , Ghodsi Mojtaba
Published: July 2022

This paper equitably compares five different Artificial Intelligence (AI) models and a linear model to tackle two real-world engineering data-driven modelling problems with small number of experimental data samples, one with sparse and one with dense data. The models of both cases are shown to be highly nonlinear. In the case with available dense data, Multi-Layer Perceptron (MLP) evidently outperforms other AI models and challenges the claims in the literature about superiority of Fully Connected Cascade (FCC). However, the results of the problem with sparse data shows superiority of FCC, closely followed by MLP and neuro-fuzzy network.
Effect of hydrolysis and succinylation on the stability of dual-modified rennet casein and membrane separated casein emulsions under different environments
Authors: Li Hongjuan , Hou Dongyu , Wu Yifei , Yuan Yujing , Li Hongbo , Yu Jinghua
Published: July 2022

Casein is a common ingredient and can be used to improve the stability of dairy products. However, the poor solubility and emulsification properties of casein limit its further application. Therefore, modification of casein to improve its application properties is important. In this study, hydrolysis and succinylation were used to modify the casein separated with different methods (rennet casein (RC) and membrane separated casein (MC)). And Turbiscan stability index (TSI), salt ion (Na+) stability, freeze-thaw stability and storage stability of emulsions prepared by RC and MC were investigated. The results showed that succinylation modified protein structure and improved the stability of oil-in-water emulsions prepared by succinylated casein and succinylated casein hydrolysates. The TSI of succinylated rennet casein (RC-SA) and succinylation of membrane separated casein hydrolysates (MC-CHs-SA) stabilized emulsions showed a better stability. Protein succinylation could prevent adsorption and aggregation between droplets, improving the Na+ stability and storage stability of the emulsion. Succinylated casein had the best emulsification activity and emulsion stability. And the solubility of succinylated casein hydrolysates was significantly improved compared with succinylated casein. Emulsions prepared with succinylated RC hydrolysates had the smallest particle size and a more uniform particle size distribution compared with other samples. Succinylated MC hydrolyzates showed the best freeze-thaw stability. Therefore, hydrolysis could reduce the molecular weight of casein and significantly improved the solubility of succinylated casein, and succinylation could modify the protein structure and significantly improved the emulsion stability. Overall, hydrolysis and succinylation can be applied to modify casein to effectively improve the application properties in emulsion system.
Evaluation the preventive effect of probiotics on infection after colorectal cancer surgery: a systematic review and meta-analysis
Authors: Miri Ali , Jajarmi Vahid , Fard Amir Mohammad Milani , Parastouei Karim , Aghaie Seyed Mojtaba , Bahrami Shabnam , Ghaleh Hadi Esmaeili Gouvarchin
Published: July 2022

Background and objectives:
The current study's objective was to evaluate the probiotics' preventative effects on postoperative infections following colorectal cancer surgery. Our review's objective is to assess the probiotics' ability to prevent infection following colorectal cancer surgery in randomized controlled studies (RCT).
Methods
to examine the randomized controlled trials throughout the previous 10 years, a search of the electronic databases of PubMed, Scopus, Web of Science, EBSCO, and Embase was carried out from 2011 until 2021. Stata/MP v.16 software was used to conduct the meta-analysis (The Stata version that runs quickly).
Results
Eleven papers total, after review of 610 articles, were chosen to do this meta-analysis. Probiotics had an odds ratio of 1.13 (OR, 1.13 95 percent CI 0.83, 1.43, P0.05) for reducing the risk of postoperative compares the treatment groups to the normal control. Probiotics' average effects on first flatus time and postoperative pyrexia duration were (OR, -0.66 95 percent CI -0.84, -0.48. P0.05) and (OR, -0.36 95 percent CI -0.74, 0.02 P = 0.06), respectively, different from control group and intervention group.
Conclusion
Patients having surgery for colorectal cancer who are postoperatively infected benefit from taking probiotics.
Copper Nanoparticles Induce Apoptosis and Oxidative Stress in SW-480 Human Colon Cancer Cell Line
Authors: Ghasemi Parvin , Shafiee Gholamreza , Ziamajidi Nasrin , Abbasalipourkabir Roghayeh
Published: July 2022

Cu nanoparticles (CuNPs) have various applications in biomedicine, owing to their unique properties. As the effect of CuNPs on the induction of oxidative stress and apoptosis in the human colorectal cancer cell line SW480 has not yet been studied, we investigated the toxicity and mechanism of action of these NPs in SW480 cells. An MTT assay was performed to assess the effect of the particles on the viability of SW480 cells. The levels of oxidative stress were assessed after 24h of treatment with CuNPs by evaluating the ROS production. Antioxidant enzyme activity was assessed using a colorimetric method. To investigate the effect of NPs on cellular apoptosis, Hoechst33258 staining was performed, and the expression of Bax, Bcl2, and p53 genes was evaluated by qRT-PCR. MTT assay results showed that CuNPs inhibited the viability of SW480 cells. Moreover, the increase in ROS production at all three concentrations (31, 68, and 100 μg/ml) was statistically significant. It has been observed that CuNPs lead to increased expression of Bax and p53, and decreased expression of Bcl-2. Hoechst staining was performed to confirm apoptosis. In conclusion, the induction of apoptosis demonstrated the anticancer potential of CuNPs.
An Introspection Monitoring Library to Improve MPI Communication Time
Authors: Jeannot Emmanuel , Sartori Richard
Published: July 2022

In this paper we describe how to improve communication time of MPI parallel applications with the use of a library that enables to monitor MPI applications and allows for introspection (the program itself can query the state of the monitoring system). Based on previous work, this library is able to see how collective communications are decomposed into point-to-point messages. It also features monitoring sessions that allow suspending and restarting the monitoring, limiting it to specific portions of the code. Experiments show that the monitoring overhead is very small and that the proposed features allow for dynamic and efficient rank reordering enabling up to 2-time reduction of communication parts of some program.
Design and Analysis of IC Engine Combustion Chamber and Piston by Composite Materials (Al & MG) Using Finite Element Analysis
Authors: Prajapati Shivam , MEHTA NISHI , THAKUR ABHISHEK NATH
Published: July 2022

Among all automotive and other industrial area components, engine pistons and combustion chambers are the most complicated. The development of an IC Engine with greater power capacity has been discovered to be appealing by the present trend. The goal of lightening the structure's weight and, by extension, reducing fuel consumption, is one of the design criteria. A better engine design has made this possible. The "Heart" of the engine is the piston and combustion chamber, and their operating conditions are the worst of all the major engine components. Therefore, it is crucial for the combustion chamber and piston's design and structural analysis. Thermal analysis and structural analysis are performed in this research. Operating gas pressure, temperature, and the material characteristics of the piston and combustion chamber are the parameters considered for the analysis. Boundary conditions employed in the analysis of pistons include pressure on the piston head under operating conditions, unequal temperature distribution from the piston head to the skirt, and heat flux and pressure for combustion chambers. In the current work, a single-cylinder, air-cooled combustion chamber and piston are created using Catia V5 software and saved in.igs format. The design is then loaded into the software Ansys (18.1 version), where analysis is then carried out. On various alloys of aluminium and magnesium, static structural analysis is first carried out, followed by thermal analysis, and the results are compared with those from FEA analysis. At the conclusion, the static structural analysis yielded three separate values: simulated outcomes, theoretical results, and percent error. The results have demonstrated that while an alloy containing a higher percentage of magnesium can tolerate high pressure and stress, the degree of deformation that results is also quite significant.
avian diversity importance in the climate of Nalanda Bihar
Authors: Mehta Jyoti , sharma gopal
Published: July 2022

This research paper was going to describe about the diversity of different types of avian in the wild life sanctuary in Nalanda Bihar. The number various kinds of species were recorded lively. Through this avian study the various types of avian were recorded which tells about the climate favourable condition according to their presence population. With help of this avian survey it was notice that the importance of conversation for this avian diversity in our ecosystem.
The Effect of Image Magnification on Measuring Radiographic Parameters for Scoliosis
Authors: Chang Yu-Tse , Yeh Yu-Cheng , Chen Wen-Jer , Lai Po-Liang
Published: July 2022

Study design
Reliability and agreement study
Background
Clinical evaluation of adolescent idiopathic scoliosis requires serial radiographic examinations. The purpose of this study was to determine whether image magnification can improve interobserver and intraobserver reliability and accuracy in the measurement of radiographic parameters of adolescent idiopathic scoliosis.
Methods
The radiographs of randomly selected scoliosis patients were reviewed. Three observers measured coronal Cobb angle, thoracic kyphosis, apical vertebral translation and sagittal vertical axis. The curves were measured as it first appeared on the screen (screen fit) without magnification (Technique 1x), 200% of screen fit (Technique 2x) and 400% of screen fit (Technique 4x). Interobserver and intraobserver reliability was assessed by intraclass correlation coefficient. We assessed the percentage of variation > 5° between the observers for each technique
Results
For coronal Cobb angle, the percentage of measurement variation > 5° was 12.5%, 1.6% for and 0% for Technique 1x, Technique 2x and Technique 4x respectively. Technique 2x was significantly better than Technique 1x in interobserver and intraobserver reliability. For thoracic hyphosis, the percentage of variation > 5° was 18.3%, 6.7% and 1.7% for Technique 1x, Technique 2x and Technique 4x respectively. Technique 4x significantly increased the interobserver and intraobserver reliability compared to Technique 1x. Measurements of distance parameters such as apical vertebral translation and sagittal vertebral axis demonstrate better reliability and were not influenced by image magnification.
Conclusions
Image magnification improves the reliability of coronal Cobb angle and thoracic kyphosis measurements. Reliability of apical vertebral translation and sagittal vertebral axis measurements are not influenced by image magnification. The authors recommend that at least 200% magnification of screen fit when measuring coronal Cobb angle and 400% magnification when measuring thoracic kyphosis.
Laparoscopic resection of right hemicolectomy, and rectal tumour for loose bowel stool: A Case Report
Authors: ALI MUHAMMAD , Ding Jianyue , Wang Yang , Diallo Maladho Tanta , Baral Shantanu , Wang Daorong
Published: July 2022

Rectal cancer with the ascending colon is rare. Herein, we report a patient who presented with diarrhea without obvious cause more than one month ago. A 67-year-old female came to our institution with frequent loose stool from one month. On CT examination, diagnosed with thickened intestinal wall at the junction of ascending colon, rectum, and sigmoid colon. Furthermore, colonoscopy exposed the rectum with stenosis and ileocecal mass. Radical resection by Dixon for rectal and hemicolectomy done for ascending colon. Postoperative pathology showed no clear vascular cancer plug invaded the entire intestinal wall and no cancer was found in the upper and lower wall. There has been no recurrence in the 25 months after the curative operation.
Icon Label Generation for MobileApplications by Mean Teacher Learning
Authors: Ma Ying , Yu ChuYi , Yan Ming
Published: July 2022

Mobile accessibility is essential to millions of smartphone users withvisual impairment issues in their daily life as the widespread mobileapplications on Google Play and the App Store. Most applicationicons lack the natural language tag to facilitate the reading of visually impaired users who struggle interacting with mobile phones usingscreen readers incorporated in mobile operating systems.COALA isa pilot work solve this issue by generating the textual label fromthe imaging icon automatically. However, most icon datasets haveimbalance distributions in the real-world scenario that only a fewcategories have rich-resource labeled samples and the major rest categories have very limited samples. To solve address the data imbalanceproblem in the icon label generation task, we provide an interconnected dual-language model with mean teacher learning, which learnsa generalized feature representation from divergent data distributions.Extensive experiments demonstrate the superiority of our dual-languagemodel over previous single-language models on different low-resourcedatasets. More experimental results show our method outperforms theCOALA model with a large margin in the label generation evaluations.
Dapagliflozin attenuates severity of atherosclerosis through manufacturing energy-crisis to inhibit ferroptosis of macrophage
Authors: Li Zhu , Jia Jia , Hao Han , Qiao Shiyang , Chen Jianzhou , Li Guannan , Qi Yu , Sun Xuan , Kang Lina , Xu Biao
Published: July 2022

BackgroundGrowing evidence has indicated that dysregulation of ferroptosis is associated with atherosclerosis. Dapagliflozin as a sodium glucose cotransporter 2 inhibitor (SGLT2i), in view of the clinically important benefits in improving cardiovascular outcomes, we aimed to explore its pharmacological effects and underlying mechanisms of atherosclerosis associated with ferroptosis.MethodFerroptosis and severity of atherosclerosis were assessed in ApoE-/- (control) and ApoE-/-+ Dapagliflozin (SGLT2i) mice groups to analyze the changes after Dapagliflozin treatment. ApoE-/-+Dapagliflozin+RSL3 (RSL3) mice group was established to confirm the association between ferroptosis and severity of atherosclerosis. Metabolism of macrophages sorted by FACS within atherosclerosis plaques were analyzed to explore the mechanism of Dapagliflozin attenuating the severity of atherosclerosis.ResultAlleviated severity of atherosclerosis and ferroptosis were observed in Dapagliflozin treatment mice group, however, RSL3 treatment mice group revoke the beneficial effect. The metabolism of macrophages sorted by Fluorescence activated Cell Sorter (FACS) within atherosclerosis plaques from Dapagliflozin treatment mice group indicated an energy crisis which mitigates ferroptosis and keeps more M2 macrophages surviving in atherosclerotic plaques.ConclusionDapagliflozin treatment attenuates severity of atherosclerosis by the way of creating energy crisis to keep more M2 macrophages surviving in atherosclerotic plaque which is more sensitive to ferroptosis than M1.
Blood monocyte to high density lipoprotein cholesterol ratio (MHR) can be used as an independent risk factor of carotid artery plaque
Authors: Xi Jie , Men Shasha , Nan Jingzhu , Yang Qiuliang , Dong JiN
Published: July 2022

Background: Carotid plaque is a manifestation of carotid atherosclerosis,monocytes play a key role in atherosclerosis related inflammatory response ,high density lipoprotein cholesterol (HDL-C) has vascular protective effects such as anti-inflammatory, antithrombotic and anti atherosclerosis. This study is to investigate the relationships of MHR level and the incidence of carotid artery plaque. Methods: Data of physical examination personnel in the first medical center of the General Hospital of PLA from January to April in 2018 was collected and 3848 subjects were included for retrospectively analysis. Statistical analysis was performed on Spss 22.0 0 software and statistical software R and its GAM package.Results: The difference was statistically significant in levels of MHR, body mass index (BMI), high-sensitive C-reactive protein (hs-CRP), blood lipids (HDL-C, low-density lipoprotein cholesterol (LDL-C), total cholesterol(TC), triglyceride(Tg)), blood glucose(Glu), Hyperglycemic hemoglobin(HbA1c), renal function (Urea, creatinine(Crea), estimated glomerular filtration rate(eGFR), Uric acid (Ua)) in carotid plaque groups (p=0.000,respectively). No significant difference between the gender (p=0.635) and age(p=0.063) in different groups. MHR levels was positively correlated with levels of BMI (r = 0.364, P = 0.000), hs-CRP (r = 0.320, P =0.000), Tg (r = 0.417, P=0.000), Crea(r=0.323, P=0.000), eGFR(r=-0.248, P=0.000), Ua(r=0.383, P=0.000) and HbA1c (r=0.197, P=0.000). Levels of TC, Glu, Urea were slightly correlated with MHR level(r=-0.150, P=0.000; r=0.187, P=0.000; r=0.137, P=0.000; respectively ). In subjects with both hypertension and diabetes, MHR levels showed difference among three groups (p=0.009). MHR level increased with elevated site number of carotid plaque in subjects without hypertension or diabetes(p=0.000). MHR level still showed differences among carotid plaque groups in subjects with hypertension and diabetes. In adjusted models, the probability of occurrence of carotid plaque increased by1.958 (95% CI: 1.144-3.351, P = 0.000) times; The probability of multiple occurrence of carotid plaques increased by 2.068 (95% CI: 1.100-3.887, P = 0.000) times. The GAM curve showed a non-linear correlation between normalized MHR and the probability of carotid plaque occurrence. Conclusions: MHR could be used as an independent risk factor and indicator for plaque formation and severity.
Hypergraph-based data modeling for binary classification
Authors: Misiorek Pawel , Janowski Szymon
Published: July 2022

We present the novel hypergraph-based framework enabling to assess the importance of data elements for the binary classification task. The proposed method explores the classification datasets modeled as a hypergraph with vertices denoting data samples and hyperedges corresponding to values of categorical features used to describe these samples. The structure of the hypergraph is applied to rate data samples and values of categorical features from the perspective of their relevance to binary classification labels. The proposed Hypergraph-based Importance (HI) ratings are theoretically-grounded on the hypergraph cut conductance minimization concept. As a result of using a hypergraph representation, which is regarded as a lossless representation from the perspective of higher-order relationships in data, our approach enables more precise exploitation of the information on feature and sample coincidences. The solution has been tested using two experimentation scenarios: random undersampling for imbalanced classification data based on an adaptive algorithm using the HI rates for data samples, and feature selection based on the HI rates for values of categorical features. The experimentation results have proven the good quality of the new approach when compared with other state-of-the-art and baseline methods for both scenarios.
Assessment of the Quality of Economic Growth in Agriculture
Authors: Abduvakhidov Akmal , Eshpulatov Dostonbek , Olimovna Kadyrova Dilafruz
Published: July 2022

The issue of economic growth is one of the main macroeconomic problems that have always been of interest to economists. Also, in the current macroeconomic situation, another side of the problem is being manifested. That is, the current issue is not only economic growth, but also the study of the factors that determine its quality has become an urgent issue. The existing theories of economic growth cannot fully explain the matter. Therefore, the article studied the issues of qualitative economic growth and evaluated statistical indicators that determine it. Indicators such as material return, capital return and labor productivity were selected as the main indicators that ensure the quality of economic growth in agriculture. As a result of the conducted research, we found out that the indicator of material return and capital return in agriculture has been decreasing. Nevertheles, the index of labor producivity has shown an increment. Moreover, the exact conclusions and suggestions were made on ensuring quality economic growth in agriculture in the country.JEL classification: Q18
FM-based Recommendation Model for Short-video with Topic Distribution
Authors: Yunfei  , Kaifeng  , Xiao  , Chen  , Lin
Published: July 2022

With the popularity of mobile internet terminals, the speed of the network and With the popularization of mobile Internet terminals, the speed of network and the reduction of traffic tariff, people can watch videos through cell phones at any time. As short videos have the characteristics of short time and rich content, they can maximize people's need to watch videos in fragmented time. Therefore, short videos that combine filming techniques, music, stories and images. Short videos can meet users' content consumption needs in a more diversified way. Due to the widespread popularity of short videos, many short video platforms have been born. Many short video platforms have been created. The short video recommendation algorithm has become an important means of competition among platforms. How to ensure the accuracy of the recommendation algorithm and the real-time of the algorithm How to ensure the accuracy of the recommendation algorithm and the real-time of the algorithm have been the focus of research. In recent years, a great deal of progress has been me in the study of problems related to preference recommendation and recommendation. The most widely used method in industry today is the use of LR to learn click-through recommendation models. LR has the vantage of being simple and very easy to implement for massively real-time parallel processing, but linear models have a limited learning capability and do not capture the information carried by higher-order features , thus limiting the recommendation performance. Based on the above analysis, this paper proposes a FM-based short video preference recommendation model from the multi-topic nature of short videos. The main contributions of the model are: Topic-based segmentation of the original training set is performed using LDA, and each sub-training set generated by the segmentation is significantly smaller than the original training set, which reduces the computational complexity to a certain extent. Automated feature selection and linear transformation of features for training sets under different topics, reducing the dependence of manual feature engineering on time and labor in the baseline algorithm. By integrating the recommendation results of different topics, thus improving the recommendation accuracy. Experiments demonstrate that our model can effectively improve the recommendation performance.
Functional and anatomical characterization of corticotropin-releasing factor receptor subtypes of the rat spinal cord involved in somatic pain relief
Authors: Mousa Shaaban , Shaqura Mohammed , Khalefa Baled , Li Li , Al-madol Mohammed , Treskatsch Sascha , Schäfer Michael
Published: July 2022

Corticotropin-releasing factor (CRF) orchestrates our body’s response to stressful stimuli. Pain is often stressful and counterbalanced by activation of CRF receptors along the nociceptive pathway, although the involvement of the CRF receptors of subtypes 1 and/or 2 (CRF-R1 and CRF-R2, respectively) in CRF-induced analgesia remains controversial. This study aimed to examine CRF-R1 and CRF-R2 expression within spinal cord of rats with Freund’s complete adjuvant-induced hindpaw inflammation using reverse transcriptase polymerase chain reaction, Western blot, radioligand binding, and immunofluorescence confocal analysis, Western blot, immunohistochemistry, and radioligand binding. Moreover, paw pressure algesiometry examined antinociceptive effects of intrathecal (i.t.) CRF and their possible antagonism through CRF-R1 and/or CRF-R2 selective antagonists as well as opioid receptor antagonist naloxone. Our results demonstrated mainly CRF-R2 mRNA, protein, binding sites and immunoreactivity in dorsal horn of rat spinal cord. In parallel, i.t. CRF as well as CRF-R2 agonists elicited potent antinociceptive effects which are dose-dependent and antagonized exclusively by i.t. CRF-R2 (K41498), but not CRF-R1 (NBI35965) antagonist. Moreover, i.t. CRF elicited inhibition of somatic pain that was dose-dependently reversed by the opioid antagonist naloxone. Consistently, double immunofluorescence confocal microscopy showed CRF-R2 on enkephalin (ENK) containing inhibitory interneurons in close opposition of incoming, mu-opioid receptor-immunoreactive nociceptive neurons but not on pre- nor on postsynaptic sensory neurons of the spinal cord. Taken together, these findings suggest that i.t. CRF or CRF-R2 agonist inhibits inflammatory somatic pain which occurs most predominantly through CRF-R2 receptors located on spinal enkephalinergic inhibitory interneurons resulting in endogenous opioid-mediated pain inhibition.