bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of environment-induced bridge vibration on high-speed train’s driving performance
Authors: He Haonan , Bi Ran , Zhao Shihao , Wang Ming , Li Xiaozhen
Published: January 2024

When railways traverse densely populated industrial areas, the periodic operation of large-scale factory equipment can produce consistent and regular environmental excitation on bridge structures. This excitation, if resonant with the structure, may cause significant vibration of the bridge, posing a threat to trains’ running safety. For the first time, this paper tackles this practical concern by combining field measurements with an analysis of how environment-induced bridge vibrations impact the operational performance of high-speed trains. The environmental vibration was equivalently incorporated into the analysis of the train-bridge coupled vibration system, examining the effects of structural vibration amplitude, frequency, and environmental influence range. The effect of bridge vibration on the driving performance of high-speed trains was evaluated from the spatial frequency domain properties of dynamic irregularity of track and the trains’ performance sensitivity to different parameters. The field measurements reveal that the environment-induced bridge vibration results in a translational motion of the beam driven by the transverse bending of the pier, resonating at approximately 1.5 Hz with an amplitude of 1.33 mm. The CRH series train, characterized by a prominent lateral mode close to 1.5 Hz (i.e., the wavelength sensitive to the train’s lateral running stability predominantly falls within the 30 m–100 m range at speed of 200∼350 km/h), exhibits a high susceptibility to vibrations induced by the environment in bridges. Among the examined parameters, the amplitude of bridge vibration has the most pronounced impact on the train’s acceleration, showing a linear correlation. The combined effect of bridge vibration and track static irregularity resulted in the lateral acceleration of the car body reaching 0.9 m/s2, which is close to the regulatory limit of 1.0 m/s2. Through parameter analysis, the maximum amplitude of the bridge that can be sustained while ensuring driving stability can be determined.
Enteric Bacterial Infections, Antimicrobial Susceptibility Pattern, Intestinal Parasites, and Associated Factors Among Food Handlers in Yabelo Town, Borena Zone, Southern Ethiopia
Authors: Gemechu Tibeso , Aliyo Alqeer
Published: January 2024

Background:

Foodborne illnesses are the main cause of morbidity and mortality in the twenty-first century, and food handlers are the main source of these illnesses.

Objective:

The study aimed to assess the prevalence of intestinal parasites, enteric bacteria, antimicrobial susceptibility patterns, and associated factors among food handlers working in a food and drinking establishment in Yabelo town, Borena zone, Southern Ethiopia, in 2022.

Methods:

A facility-based cross-sectional study design was employed to assess the food handler’s state of health. Data were gathered using semistructured questionnaires and observational checklists, and 396 regular stool samples were collected. Samples were examined with microscopy and bacteriological culture to isolate enteric bacteria. Statistical Package for the Social Sciences, version 26 The factors that had a P-value of <.05 were considered statistically significant.

Result:

Of the 396 stool samples collected, 164 (41.4%) were tested positive for intestinal parasites, while 40 (10.1%) were positive for enteric bacteria (Salmonella and Shigella). Among intestinal parasites, the most predominant parasite was Ascaris lumbricoides 48 (12.1%). All isolates of Salmonella and Shigella showed resistance to ampicillin. In multivariable analysis, not trimming fingernails regularly (AOR = 2.02, 95% CI 1.97-5.37), not washing hands with soap after the toilet (AOR = 3.02, 95% CI 2.37-5.62), and eating raw food (AOR = 2.1, 95% CI 1.79-6.51) have a significant association with the prevalence of bacteria and parasites.

Conclusion:

The majority of food handlers had poor hygiene practices, and the prevalence of parasites and bacteria was high in the study setting. Educational status, eating raw vegetables or fruit, hand washing after the toilet, and fingernail trimming have associations with the health status of food handlers.
Effect of sizing agents on tensile properties of carbon fiber filament wound structures
Authors: Zhang Shubin , Gu Hongxing , Zhao Ming , Xie Huaiqin , Huang Yudong
Published: January 2024

In order to evaluate the effects of sizing agents on the wettability, strength loss, and properties of final filament wound structures during filament winding of carbon fibers, three types of sizing agent based on epoxy, epoxy + polyester, and epoxy + polyurethane were used to treat carbon fibers, the surface properties of carbon fiber samples after treatment were evaluated using SEM, infrared spectroscopy, dynamic contact angle analysis, and interlaminar shear strength (ILSS) test, the strength loss caused by fiber damage during filament winding was quantitatively analyzed, and the strength properties of the filament wound structures were characterized by NOL ring test. The results showed that the sizing agent treatment only slightly improved the surface free energy and ILSS of carbon fibers, but it had obvious influence on the strength loss rate of carbon fiber bundles. Added polyester or polyurethane in epoxy-based sizing may improve its protective effect for carbon fiber, and thus decrease strength loss during winding process, result in better tensile properties of carbon fiber filament wound structures.
Work-support techniques used by occupational therapists to facilitate support after acquired brain injuries: A qualitative study
Authors: Kurihara Ryoko , Nagao Toru , Tanemura Rumi
Published: January 2024

Background

Ensuring effective return to work following acquired brain injuries is crucial from the perspectives of both quality of life and the economy. However, techniques of occupational therapy support for return to work remain relatively unelucidated.

Aims/Objectives

To clarify the specific contents of occupational therapy required for work and work support for clients with acquired brain injuries.

Material and Methods

An interview-based survey was conducted with participants who had >10 years of occupational therapy experience and had provided work support. We selected participants via snowball sampling. Data were analyzed using thematic analysis.

Results

A total of 20 participants (15 women and 5 men; 6, 12, 1, and 1 in their 30s, 40s, 50s, and 60s, respectively) were included. Six concepts were generated on reviewing the support for work items considered important by the occupational therapist as follows: “Support for vocational life,” “Support for interpersonal skills,” “Support for work,” “Support for illness, disability, and awareness,” “Support for utilization of compensation measures,” and “Support for goal setting.”

Conclusions

We clarified the specific contents of work support, including support for vocational life and support for work, that is administered by occupational therapists who provide work support for clients with acquired brain injury. The insights from the study improve understanding of OTs’ roles and contributions in supporting clients with acquired brain injuries in returning to work.
Assessing the efficacy of VerifyNow platelet-function testing in predicting postoperative thromboembolic complications of neuroendovascular surgery: A systematic review and meta-analysis (part 1)
Authors: Mitchell Devon L , McGuire Laura Stone , Khalid Syed I , Alaraj Ali
Published: January 2024

Background

Despite the heavily debated use of routine platelet-function testing, the VerifyNow Platelet Reactivity Unit (PRU) assay has been increasingly adopted as standard of care for assessing risk of postoperative thromboembolic complications of neuroendovascular surgery.

Objective

We conducted a systematic review and meta-analysis to examine the relationship between platelet response and risk of ischemic events from neuroendovascular surgery, assess the efficacy of point-of-care platelet-function testing in predicting thromboembolic outcomes, and assess whether a clinically useful threshold for platelet response can be defined in order to standardize guidelines.

Methods

PubMed, Embase, and Scopus were searched. Following deduplication, articles were first screened for relevance by title and abstract, followed by full text.

Results

Of 735 resultant articles, 22 studies consisting of 3266 patients undergoing neuroendovascular intervention were included. Diagnoses included both intracranial and extracranial pathologies, of which 45.8% were treated with flow diversion, 16.4% with stent-assisted coil embolization, 15.8% with intracranial stenting, 12.0% with simple coil embolization, 3.4% with balloon-assisted coil embolization, 3.6% with extracranial stenting, and 3.0% with an alternate method. 54.5% (12/22) of studies determined platelet hyporesponse to be an independent predictor of postoperative thromboembolic complications, with 27.3% (6/22) of studies reporting a similar, but non-statistically significant trend. 18.2% (4/22) of studies found no relationship between platelet response and postoperative thromboembolic complications. The estimated clinical threshold for PRU to prevent thromboembolic complications varied greatly across studies (Range: > 144–295 PRU). Meta-analysis found platelet hyporesponse to have a 2.23-fold increased risk of thromboembolic complications compared to normoresponders (RR = 2.23, P = 0.03).

Conclusion

While PRU demonstrates a significant predictive value for postoperative thromboembolic complications of neuroendovascular surgery, the target therapeutic threshold for minimizing ischemic events remains unclear. Further studies, such as large multicenter cohorts of the existing data, are needed to standardize guidelines.
Investigating responses to US drone strikes in Yemen using Twitter data
Authors: Weiss Evan , Ross Violet , Lyford Alex
Published: January 2024

As part of the War on Terror, the US conducted at least 378 air and drone strikes in Yemen from 2002 to 2023. While primarily targeting members of al-Qaeda in the Arabian Peninsula (AQAP), these strikes have killed over 1,000 people, including more than 125 civilians. This research aims to understand the broader societal impact of US military action as shown on Twitter, now known as ‘X’. The authors take a mixed-methods approach, using both qualitative and quantitative data to investigate this impact. They perform word- and tweet-level analyses on the content and sentiment of a subset of Yemeni Twitter users and contrast the content of Yemeni users’ tweets about US drone strikes with that of US users’ tweets. Finally, the article quantifies the temporal relationship between the frequency and severity of US drone strikes and Twitter activity levels in Yemen, considering the prevalence of Twitter bots.
Establishing a School Nurse Mentoring Network
Authors: Sperry Amanda , Yonkaitis Catherine F.
Published: January 2024

Often, nurses new to the school setting find they have more questions than answers about school nursing practice but no mentor to ask. Questions often arise regarding medication administration, health records, health requirements to attend school, student illness, school health legislation, and state reporting requirements in the school setting, plus many more. This article outlines how one Regional Office of Education (ROE) in central Illinois partnered with a Certified School Nurse to establish a mentoring and networking program to foster relationships and information sharing among school nurses.
Numerical modeling and simulation of cable barriers under vehicular impacts on a sloped median
Authors: Wang Qian , Palta Emre , Fang Howie
Published: January 2024

Cable barriers are flexible barrier systems that are commonly used as median barriers in the United States for their general effectiveness and low installation and maintenance costs. The current cable median barrier (CMB) adopted by the North Carolina Department of Transportation was previously evaluated on flat terrain and found to satisfy the requirements of the National Cooperative Highway Research Program Report 350. Under in-service conditions (i.e., on a sloped median), the current CMB failed to stop small passenger cars in many incidents. The new roadside safety standard, Manual for Assessing Safety Hardware (MASH), recommends that CMBs be tested and/or evaluated on sloped medians. However, conducting full-scale crash tests on sloped median is extremely difficult and few experimental studies exist. In this study, finite element simulations were used to evaluate the performance of the current CMB design on a 6H:1V sloped median under MASH Test Level 3 conditions. To address the issue of vehicle underriding on the current CMB, two retrofit designs were developed and also evaluated on the sloped median. Two MASH compliant vehicles, a 1996 Dodge Neon and a 2006 Ford F250, were used to evaluate all three CMBs from both frontside and backside and with two initial impact points. The MASH exit-box criterion, MASH Evaluation criteria A, D, and F, vehicular responses, exit angles, and residual velocities were used to evaluate the CMB performance for structural adequacy, occupant risk, and post-impact trajectories. The simulation results showed that one of the retrofit designs could improve the CMB performance on a sloped median at MASH Test Level 3 conditions.
Emergency Department and Dental Clinic Perceptions of Appropriate, and Preventable, Use of the ED for Non-Traumatic Dental Conditions in Hot-Spot Counties: A Mixed Methods Study
Authors: Schroeder Shawnda , Beck Judy , Medalen Nikki , Stepanov Anastasia
Published: January 2024

Objectives:

Frequency of emergency department (ED) use for nontraumatic dental conditions (NTDC) is a well-researched community health concern. However, research predominately relies on ambulatory ED discharge records. This explanatory sequential mixed methods study reviewed NTDC ED use in hot-spot counties and assessed perceptions around preventable and appropriate use among EDs and dental clinics.

Methods:

Tooth pain data (2015-2021) were drawn from State Medicaid, and the Early Notification of Community-Based Epidemics (ESSENCE). NTDC data were compiled using International Classification of Disease, Ninth and Tenth Revisions. Employing extreme case sampling, providers in counties with the highest per-capita NTDC ED use were interviewed.

Results:

North Dakota experienced a decline in NTDC ED visits between 2017 and 2020, though the rate is now increasing. The greatest proportion of NTDC ED visits were among persons ages 20 to 34 and 35 to 44. ED and dental care staff have misconceptions around each other’s roles in reducing NTDC ED visits, but unanimously suggest community-level prevention as a solution.

Conclusions:

NTDC ED use was perceived as “appropriate” care. However, there is consensus that improved access to, and utilization of, affordable and quality preventative dental care would reduce NTDC ED visits and improve overall community health, especially among populations experiencing greater inequities.
A Real-World Precision Medicine Program Including the KidneyIntelX Test Effectively Changes Management Decisions and Outcomes for Patients With Early-Stage Diabetic Kidney Disease
Authors: Tokita Joji , Lam David , Vega Aida , Wang Stephanie , Amoruso Leonard , Muller Tamara , Naik Nidhi , Rathi Shivani , Martin Sharlene , Zabetian Azadeh , Liu Catherine , Sinfield Catherine , McNicholas Tony , Fleming Fergus , Coca Steven G. , Nadkarni Girish N , Tun Roger , Kattan Mike , Donovan Michael J. , Rahim Arshad K.
Published: January 2024

Introduction/Objective:

The KidneyIntelX is a multiplex, bioprognostic, immunoassay consisting of 3 plasma biomarkers and clinical variables that uses machine learning to predict a patient’s risk for a progressive decline in kidney function over 5 years. We report the 1-year pre- and post-test clinical impact on care management, eGFR slope, and A1C along with engagement of population health clinical pharmacists and patient coordinators to promote a program of sustainable kidney, metabolic, and cardiac health.

Methods:

The KidneyIntelX in vitro prognostic test was previously validated for patients with type 2 diabetes and diabetic kidney disease (DKD) to predict kidney function decline within 5 years was introduced into the RWE study (NCT04802395) across the Health System as part of a population health chronic disease management program from [November 2020 to April 2023]. Pre- and post-test patients with a minimum of 12 months of follow-up post KidneyIntelX were assessed across all aspects of the program.

Results:

A total of 5348 patients with DKD had a KidneyIntelX assay. The median age was 68 years old, 52% were female, 27% self-identified as Black, and 89% had hypertension. The median baseline eGFR was 62 ml/min/1.73 m2, urine albumin-creatinine ratio was 54 mg/g, and A1C was 7.3%. The KidneyIntelX risk level was low in 49%, intermediate in 40%, and high in 11% of cases. New prescriptions for SGLT2i, GLP-1 RA, or referral to a specialist were noted in 19%, 33%, and 43% among low-, intermediate-, and high-risk patients, respectively. The median A1C decreased from 8.2% pre-test to 7.5% post-test in the high-risk group ( P < .001). UACR levels in the intermediate-risk patients with albuminuria were reduced by 20%, and in a subgroup treated with new scripts for SGLT2i, UACR levels were lowered by approximately 50%. The median eGFR slope improved from −7.08 ml/min/1.73 m2/year to −4.27 ml/min/1.73 m2/year in high-risk patients ( P = .0003), −2.65 to −1.04 in intermediate risk, and −3.26 ml/min/1.73 m2/year to +0.45 ml/min/1.73 m2/year in patients with low-risk ( P < .001).

Conclusions:

Deployment and risk stratification by KidneyIntelX was associated with an escalation in action taken to optimize cardio-kidney-metabolic health including medications and specialist referrals. Glycemic control and kidney function trajectories improved post-KidneyIntelX testing, with the greatest improvements observed in those scored as high-risk.
Demystifying Organization Success: A Bibliometric Analysis and Future Research Agenda
Authors: Bhandari Arabinda
Published: January 2024

Organizational success is multi-dimensional. Survival is essential but not a sufficient condition for the organization’s success. Considering the importance and proliferation of organizational success research, it is an opportunity to review the extant literature to guide understanding of its current and future progress. In this connection, the goal of this study is to review the performance and intellectual structure of organizational success. To do so, this study conducts a comprehensive, systematic review with bibliometric and content analysis of 370 Scopus-indexed articles based on the PRISMA framework to identify the performance (publication and citation trends, top authors and publications) and science mapping (content analysis, keyword co-occurrence analysis, bibliometric coupling) of extant literature published since 1974. This research helps to identify the most widely used 29 theories in organizational success research and provides a new avenue for future research directions. In addition to identifying key research themes, sub-themes and knowledge structures, this review would help to create value through the consolidation and quantification of the organization’s successful research evolution. This is the first comprehensive literature review article using a hybrid approach (systematic literature review, bibliometric analysis and content analysis) in organizational success.
Three Decades of Life Satisfaction: A Bibliometric Review and Research Agenda
Authors: Tanwar Samridhi , Khindri Aakash
Published: January 2024

Over the last two decades, an increasing number of studies have examined the concept of life satisfaction. Since the concept is deeply related to multiple facets of an individual’s life, it has attracted researchers’ interest from different domains. However, the life satisfaction literature is still fragmented and heterogeneous in terms of theoretical and contextual paradigms. This study aims to deconstruct the literature from the last 31 years and (i) identify distinct research clusters, (ii) reveal some major shifts in the research over time and (iii) derive some directions and ideas for future research. Using bibliometric analysis, the article identifies four clusters, and further analysis revealed a shift in theoretical perspective in life satisfaction research. Also, emerging trends within the clusters are detected. Finally, the directions for future research conclude the article.
Certification of stroke centers at primary hospitals and the improvement of thrombolysis n South China during 2020–2022
Authors: Chen Yicong , Lei Qingfeng , Li Jiaoxing , Li Jianle , He Yinxin , Li Jingjing , Xing Shihui , Fan Yuhua , Zeng Jinsheng
Published: January 2024

Introduction:

IVT use declined globally in 2020 due to the Corona Virus Disease 2019 (COVID-19) pandemic, but it increased in South China. This study was conducted to evaluate the association of establishing Stroke Prevention Centers (SPCs) at primary hospitals with IVT increase in South China.

Materials and methods:

We conducted a longitudinal observational study across 336 hospitals in 114 areas in South China during 2020–2022. Data regarding certified stroke centers, IVT volumes, and IVT rates were collected. Correlations between IVT rates and the number or density of stroke centers were accessed. IVT use was compared among areas with different levels of stroke centers or on different certification process.

Results:

During 2020–2022, there were 83, 125, and 152 stroke centers, with 26, 65, and 92 SPCs, respectively. IVT therapies were 12,795, 17,266, and 20,411, representing a 29.8% increase/year (all p < 0.001). IVT rates increased from 7.2% in 2020 to 8.8% and 10.4% in 2021 and 2022, demonstrating a 22.2% increase/year (all p < 0.001). IVT rates correlated with the number and density of SPCs (all p < 0.05). IVT rates were higher in areas equipped with SPCs than in those without stroke centers (all p < 0.05). IVT rates consistently increased during the SPC certification process from 1 year before through the certification and subsequent maintenance (both p < 0.05).

Discussion and conclusion:

Well-organised SPCs and IVT therapy demonstrated substantial increase during the 3-year period. Certification of SPCs at primary hospitals is associated with improved IVT therapy in South China even with city lockdown during COVID-19 pandemic.
A case study of pragmatic measure development of the Treatment Integrity for Elementary Settings self-report measure for teachers
Authors: Dear Emma R. , McLeod Bryce D. , Peterson Nicole M. , Sutherland Kevin S. , Broda Michael D. , Dopp Alex R. , Lyon Aaron R.
Published: January 2024

Introduction

Due to usability, feasibility, and acceptability concerns, observational treatment fidelity measures are often challenging to deploy in schools. Teacher self-report fidelity measures with specific design features might address some of these barriers. This case study outlines a community-engaged, iterative process to adapt the observational Treatment Integrity for Elementary Settings (TIES-O) to a teacher self-report version designed to assess the use of practices to support children's social-emotional competencies in elementary classrooms.

Method

Cognitive walkthrough interviews were conducted with teachers to improve the usability of the teacher self-report measure, called the Treatment Integrity for Elementary Schools–Teacher Report (TIES-T). Qualitative content analysis was used to extract themes from the interviews and inform changes to the measure.

Results

Increasing clarity and interactive elements in the measure training were the dominant themes, but suggestions for the measure format and jargon were also suggested.

Conclusion

The suggested changes resulted in a brief measure, training, and feedback system designed to support the teacher's use of practices to support children's social-emotional competencies in elementary classrooms. Future research with the TIES-T will examine the score reliability and validity of the measure.
Medical Student Attitudes Toward Patients With Substance Use Disorder After Experiential Learning on an Addiction Psychiatry Consultation-Liaison Service: A Pilot Study
Authors: Lew Brandon J. , Balasanova Alëna A.
Published: January 2024

Background:

Stigma surrounding substance use disorder (SUD) is highly prevalent in health care. Negative attitudes toward patients with SUD have been shown to negatively impact patient care. Addressing SUD stigma in medical students is a promising approach, however, few curricula include experiential learning on addiction psychiatry clinical services. We describe a medical student rotation on an addiction psychiatry clinical service and examine its effect on attitudes toward patients with SUD.

Methods:

Medical students were integrated onto an addiction psychiatry consultation-liaison service serving medically/surgically hospitalized patients with co-occurring SUD and other psychiatric disorders. Students learned and practiced in-person assessment of patients and received instruction on basic principles of psychiatry and evaluation and management of SUD. A targeted anti-stigma curriculum was included. Attitudes toward patients with SUD were measured with the Medical Condition Regard Scale (MCRS) before and after the experience. Each item of the MCRS and an overall composite attitude score were analyzed.

Results:

Of the 36 students on the clinical rotation, 33 completed the survey. Attitudes showed widespread improvement toward patients with SUD. Mann–Whitney U tests showed significant improvement in most items of the MCRS. Further analysis of composite scores showed an improvement in overall attitudes toward patients with SUD.

Conclusions:

Inclusion of medical students on an addiction psychiatry consult service as part of the core psychiatry clerkship may hold promise for helping improve student attitudes and decrease stigma toward patients with SUD. Controlled study is needed to compare other clinical experiences and determine specific causative effects.
Modeling post-disaster recovery: Accounting for rental and multi-family housing
Authors: Mongold Emily , Costa Rodrigo , Zsarnóczay Ádám , Baker Jack W
Published: January 2024

Post-disaster housing recovery models increase our understanding of recovery dynamics, vulnerable populations, and how people are affected by the direct losses that disasters create. Past recovery models have focused on single-family owner-occupied housing, while empirical evidence shows that rental units and multi-family housing are disadvantaged in post-disaster recovery. To fill this gap, this article presents an agent-based housing recovery model that includes the four common type–tenure combinations of single- and multi-family owner- and renter-occupied housing. The proposed model accounts for the different recovery processes, emphasizing funding sources available to each type–tenure. The outputs of our model include the timing of financing and recovery at building resolution across a community. We demonstrate the model with a case study of Alameda, California, recovering from a simulated M7.0 earthquake on the Hayward fault. The processes in the model replicate higher non-recovery of multi-family housing than single-family housing, as observed in past disasters, and a heavy reliance of single-family renter-occupied units on Small Business Administration funding, which is expected due to low earthquake insurance penetration. The simulation results indicate that multi-family housing would have the highest portion of unmet need remaining; however, some buildings with unmet needs are anticipated to be able to obtain a large portion of their funding. The remaining portion may be filled using personal financing or may be overcome with downsizing or downgrades. Multi-family housing would also benefit the most from Community Development Block Grants for Disaster Recovery (CDBG-DR). This benefit is a result of modeling the financing sources, that CDBG-DR is available, and that many multi-family buildings do not qualify for other sources. Communities’ allocation of public funding is important for housing recovery. Our model can help inform and compare potential financing policies to allocate public funds.
Improving stroke outcomes in hyperglycemic mice by modulating tPA/NMDAR signaling to reduce inflammation and hemorrhages
Authors: Lebrun Florent , Levard Damien , Lemarchand Eloïse , Yetim Mervé , Furon Jonathane , Potzeha Fanny , Marie Pauline , Lesept Flavie , Blanc Manuel , Haelewyn Benoit , Rubio Marina , Letourneur Annelise , Violle Nicolas , Orset Cyrille , Vivien Denis
Published: January 2024

The pharmacological intervention for ischemic stroke hinges on intravenous administration of the recombinant tissue-type plasminogen activator (rtPA, Alteplase/Actilyse) either as a standalone treatment or in conjunction with thrombectomy. However, despite its clinical significance, broader use of rtPA is constrained because of the risk of hemorrhagic transformations (HTs). Furthermore, the presence of diabetes or chronic hyperglycemia is associated with an elevated risk of HT subsequent to thrombolysis. This detrimental impact of tPA on the neurovascular unit in patients with hyperglycemia has been ascribed to its capacity to induce endothelial N-methyl-D-aspartate receptor (NMDAR) signaling, contributing to compromised blood-brain barrier integrity and neuroinflammatory processes. In a mouse model of thromboembolic stroke with chronic hyperglycemia, we assessed the effectiveness of rtPA and N-acetylcysteine (NAC) as thrombolytic agents. We also tested the effect of blocking tPA/NMDAR signaling using a monoclonal antibody, Glunomab. Magnetic resonance imaging, speckle contrast imaging, flow cytometry, and behavioral tasks were used to evaluate stroke outcomes. In hyperglycemic animals, treatment with rtPA resulted in lower recanalization rates and increased HTs. Conversely, NAC treatment reduced lesion sizes while mitigating HTs. After a single administration, either in standalone or combined with rtPA-induced thrombolysis, Glunomab reduced brain lesion volumes, HTs, and neuroinflammation after stroke, translating into improved neurological outcomes. Additionally, we demonstrated the therapeutic efficacy of Glunomab in combination with NAC or as a standalone strategy in chronic hyperglycemic animals. Counteracting tPA-dependent endothelial NMDAR signaling limits ischemic damages induced by both endogenous and exogenous tPA, including HTs and inflammatory processes after ischemic stroke in hyperglycemic animals.
Pathogenicity assessment of Arcobacter butzleri isolated from Canadian agricultural surface water
Authors: Khan Izhar U. H. , Chen Wen , Cloutier Michel , Lapen David R. , Craiovan Emilia , Wilkes Graham
Published: January 2024

Background

Water is considered a source for the transmission of Arcobacter species to both humans and animals. This study was conducted to assess the prevalence, distribution, and pathogenicity of A. butzleri strains, which can potentially pose health risks to humans and animals. Cultures were isolated from surface waters of a mixed-use but predominately agricultural watershed in eastern Ontario, Canada. The detection of antimicrobial resistance (AMR) and virulence-associated genes (VAGs), as well as enterobacterial repetitive intergenic consensus-polymerase chain reaction (ERIC-PCR) assays were performed on 913 A. butzleri strains isolated from 11 agricultural sampling sites.

Results

All strains were resistant to one or more antimicrobial agents, with a high rate of resistance to clindamycin (99%) and chloramphenicol (77%), followed by azithromycin (48%) and nalidixic acid (49%). However, isolates showed a significantly (p < 0.05) high rate of susceptibility to tetracycline (1%), gentamycin (2%), ciprofloxacin (4%), and erythromycin (5%). Of the eight VAGs tested, ciaB, mviN, tlyA, and pldA were detected at high frequency (> 85%) compared to irgA (25%), hecB (19%), hecA (15%), and cj1349 (12%) genes. Co-occurrence analysis showed A. butzleri strains resistant to clindamycin, chloramphenicol, nalidixic acid, and azithromycin were positive for ciaB, tlyA, mviN and pldA VAGs. ERIC-PCR fingerprint analysis revealed high genetic similarity among strains isolated from three sites, and the genotypes were significantly associated with AMR and VAGs results, which highlight their potential environmental ubiquity and potential as pathogenic.

Conclusions

The study results show that agricultural activities likely contribute to the contamination of A. butzleri in surface water. The findings underscore the importance of farm management practices in controlling the potential spread of A. butzleri and its associated health risks to humans and animals through contaminated water.
Modulations of wheat growth by selenium nanoparticles under salinity stress
Authors: Zafar Sara , Hasnain Zuhair , Danish Subhan , Battaglia Martin Leonardo , Fahad Shah , Ansari Mohammad Javed , Alharbi Sulaiman Ali
Published: January 2024

Salinity stress is a prominent environmental factor that presents obstacles to the growth and development of plants. When the soil contains high salt concentrations, the roots face difficulties in absorbing water, resulting in water deficits within the plant tissues. Consequently, plants may experience inhibited growth, decreased development, and a decline in biomass accumulation. The use of nanoparticles has become a popular amendment in recent times for the alleviation of salinity stress. The study investigated the biological approach for the preparation of Se nanoparticles (NP) and their effect on the growth of wheat plants under saline conditions. The leaf extract of lemon (Citrus limon L.) was used for the green synthesis of selenium nanoparticles (Se-NPs). The synthesized NPs were characterized by X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR) and were applied foliar in the range of 0.01%, 0.05% and 0.1% on wheat plants. Results showed that 0.1% SeNP alone exhibited a significantly higher yield per plant, biomass per plant, 1000 grains weight, chlorophyll a, chlorophyll b and total chlorophyll over the SS (salt stress) control. A significant decline in MDA and H2O2 also validated the effectiveness of 0.1% SeNP over the SS control.
Pericardial effusion in children at tertiary national referral hospital, Addis Ababa, Ethiopia: a 7-year institution based review
Authors: Amare Selamawit , Tadele Henok
Published: January 2024

Background

Pericardial effusion (PE) is a rare yet an important cause of child mortality due to collection of excess fluid in pericardial space. The study aimed to describe the PE profile in the national cardiac referral hospital, Addis Ababa, Ethiopia.

Methods

The study employed cross-sectional study design for a 7-year review of childhood PE in Tikur Anbessa Specialized Hospital. Descriptive and analytic statistics were applied.

Results

There were 17,386 pediatric emergency/ER admissions during the study period, and PE contributed to 0.47% of ER admissions. From 71 included subjects, 59% (42) were males with mean age of 7.8 ± 3.3 years. Cough or shortness of breath,73.2% (52) and fever or fast breathing, 26.7% (19), were the common presenting symptoms. The median duration of an illness before presentation was 14days (IQR: 8–20). The etiologies for pericardial effusion were infective (culture positive–23.9%, culture negative–43.6%, tuberculous-4.2%), hypothyroidism (4.2%), inflammatory (12.7%), malignancy (7%) or secondary to chronic kidney disease (1. 4%). Staphylococcus aureus was the most common isolated bacteria on blood culture, 12.7% (9) while the rest were pseudomonas, 7% (5) and klebsiella, 4.2% (3). Mild, moderate and severe pericardial effusion was documented in 22.5% (16), 46.5% (33), and 31% (22) of study subjects, respectively. Pericardial tamponade was reported in 50.7% (36) of subjects. Pericardial drainage procedure (pericardiocentesis, window or pericardiotomy) was performed for 52.1% (37) PE cases. The case fatality of PE was 12.7% (9). Pericardial drainage procedure was inversely related to mortality, adjusted odds ratio 0.11(0.01–0.99),p0.049).

Conclusion

PE contributed to 0.47% of ER admissions. The commonest PE presentation was respiratory symptoms of around two weeks duration. Purulent pericarditis of staphylococcal etiology was the commonest cause of PE and the case fatality rate was 12.7%. Pericardial drainage procedures contributed to reduction in mortality. All PE cases should be assessed for pericardial drainage procedure to avoid mortality.
The impact of the COVID-19 pandemic on transfers between long-term care and emergency departments across Alberta
Authors: Wyer Leanna , Guterman Yair , Ewa Vivian , Lang Eddy , Faris Peter , Holroyd-Leduc Jayna
Published: January 2024

Background

Long-term care (LTC) was overwhelmingly impacted by COVID-19 and unnecessary transfer to emergency departments (ED) can have negative health outcomes. This study aimed to explore how the COVID-19 pandemic impacted LTC to ED transfers and hospitalizations, utilization of community paramedics and facilitated conversations between LTC and ED physicians during the first four waves of the pandemic in Alberta, Canada.

Methods

In this retrospective population-based study, administrative databases were linked to identify episodes of care for LTC residents who resided in facilities in Alberta, Canada. This study included data from January 1, 2018 to December 31, 2021 to capture outcomes prior to the onset of the pandemic and across the first four waves. Individuals were included if they visited an emergency department, received care from a community paramedic or whose care involved a facilitated conversation between LTC and ED physicians during this time period.

Results

Transfers to ED and hospitalizations from LTC have been gradually declining since 2018 with a sharp decline seen during wave 1 of the pandemic that was greatest in the lowest-priority triage classification (CTAS 5). Community paramedic visits were highest during the first two waves of the pandemic before declining in subsequent waves; facilitated calls between LTC and ED physicians increased during the waves.

Conclusions

There was a reduction in number of transfers from LTC to EDs and in hospitalizations during the first four waves of the pandemic. This was supported by increased conversations between LTC and ED physicians, but was not associated with increased community paramedic visits. Additional work is needed to explore how programs such as community paramedics and facilitated conversations between LTC and ED providers can help to reduce unnecessary transfers to hospital.
Impact of the COVID-19 pandemic on prehospital and in-hospital treatment and outcomes of patients after out-of-hospital cardiac arrest: a Japanese multicenter cohort study
Authors: Tanaka Chie , Tagami Takashi , Kaneko Junya , Kitamura Nobuya , Yasunaga Hideo , Aso Shotaro , Takeda Munekazu , Kuno Masamune
Published: January 2024

Background

In the chain of survival for Out-of-hospital cardiac arrest (OHCA), each component of care contributes to improve the prognosis of the patient with OHCA. The SARS-CoV-2 (COVID-19) pandemic potentially affected each part of care in the chain of survival. The aim of this study was to compare prehospital care, in-hospital treatment, and outcomes among OHCA patients before and after the COVID-19 pandemic.

Methods

We analyzed data from a multicenter prospective study in Kanto area, Japan, named SOS-KANTO 2017. We enrolled patients who registered during the pre-pandemic period (September 2019 to December 2019) and the post-pandemic period (June 2020 to March 2021). The main outcome measures were 30-day mortality and the proportion of favorable outcomes at 1 month, and secondary outcome measures were changes in prehospital and in-hospital treatments between the pre- and post-pandemic periods.

Results

There were 2015 patients in the pre-pandemic group, and 5023 in the post-pandemic group. The proportion of advanced airway management by emergency medical service (EMS) increased (p < 0.01), and EMS call-to-hospital time was prolonged (p < 0.01) in the post- versus pre-pandemic group. There were no differences between the groups in defibrillation, extracorporeal membrane oxygenation, or temperature control therapy (p = 0.43, p = 0.14, and p = 0.16, respectively). Survival rate at 1 month and favorable outcome rate at 1 month were lower (p = 0.01 and p < 0.01, respectively) in the post- versus pre-pandemic group.

Conclusion

Survival rate and favorable outcome rate 1 month after return of spontaneous circulation of OHCA worsened, EMS response time was prolonged, and advanced airway management by EMS increased in the post- versus pre-pandemic group; however, most prehospital and in-hospital management did not change between pre- and post-COVID-19 pandemic.
Re-expressing coefficients from regression models for inclusion in a meta-analysis
Authors: Linakis Matthew W. , Van Landingham Cynthia , Gasparini Alessandro , Longnecker Matthew P.
Published: January 2024

Meta-analysis poses a challenge when original study results have been expressed in a non-uniform manner, such as when regression results from some original studies were based on a log-transformed key independent variable while in others no transformation was used. Methods of re-expressing regression coefficients to generate comparable results across studies regardless of data transformation have recently been developed. We examined the relative bias of three re-expression methods using simulations and 15 real data examples where the independent variable had a skewed distribution. Regression coefficients from models with log-transformed independent variables were re-expressed as though they were based on an untransformed variable. We compared the re-expressed coefficients to those from a model fit to the untransformed variable. In the simulated and real data, all three re-expression methods usually gave biased results, and the skewness of the independent variable predicted the amount of bias. How best to synthesize the results of the log-transformed and absolute exposure evidence streams remains an open question and may depend on the scientific discipline, scale of the outcome, and other considerations.
The P2Y1 receptor in the colonic myenteric plexus of rats and its correlation with opioid-induced constipation
Authors: Zhao Yuqiong , Luo Huijuan , Ren Xiaojie , Jia Binghan , Li Jinzhao , Wang Lixin , Li Junping
Published: January 2024

This study was designed to explore the expression changes of P2Y1 receptors in the distal colonic myenteric layer of rats. An opioid induced constipation(OIC) rat model was generated by intraperitoneal (i.p) injection of loperamide. At 7 days post-treatment, the model rats were assessed by calculating the fecal water content and the gastrointestinal transit ratio. The immunofluorescence (IF)-based histochemical study was used to observe the distribution of P2Y1 receptors in the distal colonic myenteric plexus. Western blotting (WB) was performed to evaluate the expression changes of P2Y1 proteins in the myenteric layer, and the electrophysiological approaches were carried out to determine the regulatory roles of P2Y1 receptors on distal colonic motor function. IF showed that P2Y1 receptors are co-expressed MOR in the enteric nerve cells of the distal colonic myenteric plexus. Moreover, the WB revealed that the protein levels of P2Y1 were significantly decreased in the distal colonic myenteric layer of OIC rats. In vitro tension experiments exhibited that the P2Y1 receptor antagonist MRS2500 enhanced the spontaneous contraction amplitude, adding EM2 and β-FNA did not have any effect on MRS2500. Therefore, P2Y1 receptor expression could be associated with the occurrence of OIC in this rat model and the regulation of colonic motility by MOR may be related to the release of purine neurotransmitters such as ATP in the colonic nervous system.
Oral health and healthy ageing: a scoping review
Authors: Poudel Prakash , Paudel Grish , Acharya Reecha , George Ajesh , Borgnakke Wenche S. , Rawal Lal B.
Published: January 2024

Background

Good oral health is an important part of healthy ageing, yet there is limited understanding regarding the status of oral health care for older people globally. This study reviewed evidence (policies, programs, and interventions) regarding oral health care for older people.

Methods

A systematic search of six databases for published and grey literature in the English language by the end of April 2022 was undertaken utilising Arksey and O’Malley’s scoping review framework.

Results

The findings from oral health policy documents (n = 17) indicated a lack of priorities in national health policies regarding oral health care for older people. The most common oral health interventions reported in the published studies (n = 62) included educational sessions and practical demonstrations on oral care for older adults, nurses, and care providers. Other interventions included exercises of facial muscles and the tongue, massage of salivary glands, and application of chemical agents, such as topical fluoride.

Conclusion

There is currently a gap in information and research around effective oral health care treatments and programs in geriatric dental care. Efforts must be invested in developing guidelines to assist both dental and medical healthcare professionals in integrating good oral health as part of healthy ageing. Further research is warranted in assessing the effectiveness of interventions in improving the oral health status of the elderly and informing approaches to assist the integration of oral health into geriatric care.