bluuebunny/crossref_metadata_2025 huggingface dataset:
Canções, poesias e Modernismo em concerto: a gravadora Festa e a busca pela autonomia
Authors: Freire Guilherme
Published: March 2022

Neste artigo tratamos da trajetória da gravadora Festa (1955-1967), do produtor Irineu Garcia, que desempenhou um papel fundamental por ter produzido discos para segmentos de circulação restrita no mercado que ganharam grande relevância histórica. Ao analisar a produção da gravadora, avaliamos de que modo o seu perfil de atuação no mercado – que ficou marcado pelo lançamento de LP’s com poesia recitada pelas vozes de poetas modernistas brasileiros consagrados, discos de música erudita nacional e de artistas de música popular com letras e arranjos próximos da esfera culta–, refletiu algumas transformações que ocorriam no âmbito mais amplo das indústrias culturais do período associado tanto ao desenvolvimento da base técnica como ao recrudescimento da segmentação do mercado de bens simbólicos em curso.
Arte concreta em São Paulo e a música “popcreta” do Grupo Música Nova
Authors: Magre Fernando
Published: March 2022

O Concretismo foi um marco no campo das artes plásticas mundial. Em fins dos anos 1940, essa estética se introjetou na plástica brasileira, tornando-se, na década seguinte, o paradigma da pintura no país. Sua disseminação atingiu outros campos artísticos, fecundando o solo para o surgimento da poesia concreta e resvalando sobre a música de vanguarda do Grupo Música Nova. Com o golpe militar, o projeto formalista do Concretismo se abriu para uma fase semântica, que se tornou conhecido como popcreto devido a uma exposição realizada pelo artista plástico Waldemar Cordeiro e por Augusto de Campos, com participação musical de Damiano Cozzella. Neste trabalho, partimos do pressuposto de que é possível identificar na música do Grupo Música Nova, especialmente em sua música-teatro, um dos procedimentos mais característicos do Concretismo paulista em sua fase semântica, a saber: a crítica social por meio da incorporação de objetos oriundos da cultura de massa e da sociedade de consumo. Para tal, fazemos uma análise comparativa entre o Manifesto Música Nova, publicado em 1963 pelo referido grupo, e textos de Waldemar Cordeiro e seus estudiosos. A partir da consonância encontrada entre os textos, analisamos a obra Cidade de Gilberto Mendes, composta em 1964, sobre o poema concreto de Augusto de Campos, identificando como tais procedimentos se materializam em uma composição musical. Chegamos à conclusão de que a música-teatro, por sua característica cênico-musical – portanto, visual e sonora –, ofereceu os meios para a elaboração do Concretismo semântico, popcreto, dentro do campo da música de concerto brasileira.
Structural behavior of ferrocement composite hollow-cored panels for roof construction
Authors: Shaheen Yousry B. I. , Etman Zeinab A. , Elrefy Aya M.
Published: March 2022

The main objective of the following work is to study the effect of using different types of metallic and non-metallic mesh reinforcement materials on the flexural behavior of ferrocement hollow-cored panels as a viable alternative for conventional reinforced concrete roofs. The proposed panels are lighter in weight relative to the conventional reinforced concrete panels. Three types of the steel meshes were used to reinforce the ferrocement skin layers. Namely: welded wire mesh, expanded metal mesh, and tenax mesh with various numbers of layers. Experimental investigation was conducted on the proposed panels. A total of ten slabs having the total dimensions of 2000 mm length, 500 mm width and 120 mm thickness were cast and tested under flexural loadings until failure. The deformation characteristics and cracking behavior were recorded and observed for each panel at all stages of loadings. The results showed that high ultimate and serviceability loads, crack resistance control, high ductility, and good energy absorption properties could be achieved by using the proposed panels. This could be of true construction merits for both developed and developing countries alike. The experimental results were then compared to analytical models using (ABAQUS/Explicit) programs. The finite element (FE) simulations achieved better results in comparison with the experimental results.
Effect of expanded polystyrene beads on the properties of foam concrete containing polypropylene fiber
Authors: Canbaz Mehmet , Türeyen Ali Can
Published: March 2022

In this study, foam concrete was produced using 3 different volumes of EPS beads (up to 100%), 3 different volumes of polypropylene(PP) fiber (up to 0.1)%, sand and 40% pre-produced foam which is fixed by volume. The water-cement ratio was 0.4 and the sand-cement ratio was chosen as 1. The foam concrete were cast into molds with a size of 100 x 100 x 500 mm and 150 x 150 x 150 mm prism. Unit weight, ultrasonic pulse, water absorption, splitting tensile strength, bending strength and compressive strength tests were achieved. Foam concrete were kept in laboratory standard conditions. According to the results of study, unit weight and ultrasonic pulse velocity vary between 970-1350 kg/m3 and 1.6-2.6 km/sec, respectively. The water absorption of the foam concrete decreased up to 65% as the EPS beads ratio increased. Since EPS beads do not contribute to the strength and act like a void, splitting tensile strength in specimens containing EPS beads decreased by up to 70%. The use of fiber contributes to the splitting tensile strength, especially in specimens that do not contain EPS beads, and it increased the strength by 78%. Similarly, the flexural strength of the PP fiber addition increased by up to 70%. As the EPS beads ratio increased, the flexural strengths decreased by 77%. With the addition of PP fiber, the compressive strength increased by 55%. However, since EPS beads' strength is negligible, it caused a 60% decrease in compressive strength.
O PAPEL DA MÚSICA EM COMUNICAÇÕES DE SERVIÇOS PÚBLICOS DE SAÚDE: um estudo de caso sobre a vacinação contra o covid-19 no Brasil
Authors: Dias de Faria Marina , Silva Nascimento Beatriz , Pereira Barbosa José Geraldo
Published: March 2022

O presente estudo teve como objetivo principal analisar o papel da música nas comunicações de serviços públicos de saúde direcionadas à vacinação contra o COVID-19 no Brasil na percepção dos receptores da publicidade. Realizou-se análise de conteúdo de textos culturais de redes sociais oficiais e manifestações da sociedade e entrevistas semiestruturadas com moradores de cada região do país. Destacou-se a música como instrumento eficaz para publicidade de serviços públicos de saúde, influenciando brasileiros de diversas idades, facilitando a transmissão da mensagem, combatendo o medo e a desinformação.
NYAH! FANFICTION AND THE TRANSFORMATIONS OF LOVE
Authors: Luís dos Santos André , Drigo Maria Ogécia
Published: March 2022

This paper aims to make explicit how love is updated in romances produce by fans from Nyah! Fanfiction, as well as to evaluate if such community can be configured as a Community of Inquiry. We present reflections upon the concept of Community of Inquiry, proposed by Peirce, and upon the transformations of intimacy in contemporaneity, with Gidens, which permeate the analysis of a romance by content analysis, according to Bardin. The analyzed romance amalgamates specificities of passionate, romantic and pure love and, thanks to the interaction emprehended in the community, fans can resize their beliefs about love.
A Spatially Bounded Airspace Axiom
Authors: Szabó Peter , Ferencová Miroslava , Blišťanová Monika
Published: March 2022

Free route airspace (FRA) is a new concept of European air transport. It has been designed to eliminate the negative impact of air traffic on the environment, minimize fuel consumption, simplify and expand flight planning. In our research, FRA is modelled by using graph theory, networks, and convex analysis. We also looked for answers to the question which are the basic mathematical properties of airspace? Basic mathematical properties are expressed using axioms. Therefore, in our work, we state the general, basic axiom of airspace based on our FRA research. The axiom is given using practical, significant entry points and geodetic coordinates.
ApoA1 Deficiency Reshapes the Phenotypic and Molecular Characteristics of Bone Marrow Adipocytes in Mice
Authors: Kastrenopoulou Afroditi , Kypreos Kyriakos , Papachristou Nicholaos , Georgopoulos Stavros , Mastora Ioulia , Papadimitriou-Olivgeri Ioanna , Spentzopoulou Argyro , Nikitovic Dragana , Kontogeorgakos Vassilios , Blair Harry C. , Papachristou Dionysios J.
Published: March 2022

In the present study, we studied the effect of apolipoprotein A-1 (APOA1) on the spatial and molecular characteristics of bone marrow adipocytes, using well-characterized ApoA1 knockout mice. APOA1 is a central regulator of high-density lipoprotein cholesterol (HDL-C) metabolism, and thus HDL; our recent work showed that deficiency of APOA1 increases bone marrow adiposity in mice. We found that ApoA1 deficient mice have greatly elevated adipocytes within their bone marrow compared to wild type counterparts. Morphologically, the increased adipocytes were similar to white adipocytes, and displayed proximal tibial-end localization. Marrow adipocytes from wild type mice were significantly fewer and did not display bone-end distribution pattern. The mRNA levels of the brown/beige adipocyte-specific markers Ucp1, Dio2, Pat2, Pgc1a, and the expression of leptin were greatly reduced in the ApoA1 knock-out in comparison to the wild-type mice. In the knock-out mice adiponectin was remarkably elevated. In keeping with the close ties of hematopoietic stem cells and marrow adipocytes, we found that the elevated adiposity in the ApoA1 knock out mice is associated with a significant reduction of the hematopoietic stem cells and common myeloid, but not common lymphoid, progenitors. Moreover, the “beiging”-related marker osteopontin and the angiogenic factor VEGF were also reduced in the ApoA1 knock-out mice, further supporting the notion that APOA1, and most probably HDL-C, regulate bone marrow microenvironment, favouring beige/brown adipocyte characteristics.
Discovery of Bispecific Lead Compounds From Azadirachta Indica Against ZIKA NS2B-NS3 Protease and RNA Dependent RNA Polymerase Using Molecular Simulations
Authors: Kumar Sanjay , El- Kafrawy‎ Shreif A. , Bharadwaj Shiv , Maitra S. S. , Alandijany Thamir A. , Faizo Arwa A. , Khateb Aiah M. , Dwivedi Vivek Dhar , Azhar Esam I.
Published: March 2022

Zika virus (ZIKV) has been characterized as one of the potential pathogens and placed under future epidemic outbreaks by the WHO. However, lack of potential therapeutics can result in uncontrolled pandemic like other human pandemic viruses; therefore, prioritized effective therapeutics development has been recommended against ZIKV. In this context, the present study adopted the strategy to explore the lead compounds from Azadirachta indica against ZIKV via concurrent inhibition of the ZIKVpro and ZIKVRdRp proteins using molecular simulations. Initially, structure-based virtual screening of 44 bioflavonoids reported in Azadirachta indica against the crystal structures of targeted ZIKV proteins resulted in the identification of top four common bioflavonoids, viz. rutin, nicotiflorin, isoquercitrin, and hyperoside. These compounds showed substantial docking energy (-7.9 to -11.01 kcal/mol) and intermolecular interactions with essential residues of ZIKVpro (His51, Asp74, and Ser135) and ZIKVRdRp (Asp540, Ile799, and Asp665) by comparison to the reference compounds, O7N inhibitor (ZIKVpro) and Sofosbuvir inhibitor (ZIKVRdRp). Long interval molecular dynamics simulation (500 ns) on the selected docked poses reveals the stability of respective docked complexes contributed by intermolecular hydrogen bonds and hydrophobic interactions. The predicted complex stability was further supported by calculated end-point binding free energy using molecular mechanics generalized born surface area (MM/GBSA) method. Consequently, the identified common bioflavonoids are recommended as promising therapeutic inhibitors of ZIKVpro and ZIKVRdRp for further experimental assessment.
Methods for the Quantification of Particle-Bound Protein – Application to Reagents for Lateral-Flow Immunoassays (LFIA)
Authors: Tchipilov Teodor , Raysyan Anna , Weller Michael G.
Published: March 2022

Protein immobilization for the functionalization of particles is used in various applications, including biosensors, lateral-flow immunoassays (LFIA), bead-based assays, and others. Common methods for the quantification of bound protein are measuring protein in the supernatant before and after coating and calculating the difference. This popular approach has the potential for a significant overestimation of the amount of immobilized protein since layers not directly bound to the surface (soft protein corona) are usually lost during washing and handling. Only the layer directly bound to the surface (hard corona) can be used in subsequent assays. A simplified amino acid analysis method based on acidic hydrolysis and RP-HPLC-FLD of tyrosine and phenylalanine (aromatic amino acid analysis, AAAA) is proposed to directly quantify protein bound to the surface of gold nano- and latex microparticles. The results are compared with indirect methods such as colorimetric protein assays, such as Bradford, bicinchoninic acid (BCA), as well as AAAA of the supernatant. For both particle types, these indirect quantification techniques show a protein overestimation of up to 1700% compared to the direct AAAA measurements. In addition, protein coating on latex particles was performed both passively through adsorption and covalently through EDC/sulfo-NHS chemistry. Our results showed no difference between the immobilization methodologies. This finding suggests that usual protein determination methods are no unambiguous proof of a covalent conjugation on particles or beads.
Method of Formulating 3D-Printable Strain-Hardening Geopolymer Composites for Additive Construction
Authors: Bong Shin Hau , Nematollahi Behzad , Naidu Nerella Venkatesh , Mechtcherine Viktor
Published: March 2022

One of the major limitations of the current 3D-concrete-printing technology is incorporation of reinforcement. Furthermore, there is a need to decrease the ecological footprint of printable concrete. As a possible solution for these challenges, this paper presents a 3D-printable strain-hardening geopolymer composite (3DP-SHGC) that shows pseudo-ductile behaviour under direct tension. The developed 3DP-SHGC is composed of one-part (just-add-water) geopolymer binder made of slag (GGBFS), fly ash (FA) and solid activator. The one-part geopolymer binder eliminates the need for elevated temperature curing and handling of corrosive alkaline liquids. At first, an optimum matrix was identified by studying the effects of FA to GGBFS ratio on the rheological properties and compressive strength. Subsequently the optimum matrix was reinforced by PVA fibres to make the 3DP-SHGC, which printing performance and rheological properties were evaluated. In addition, the influences of curing temperature on the compressive, flexural and tensile performances of the printed specimens were also investigated. The results were compared with those obtained for the mould-cast specimens. The 3DP-SHGC exhibited superior flexural performance, higher tensile strength, and comparable tensile strain capacity to the mould-cast counterpart. Further, the curing temperature had influence on the mechanical properties of both 3D-printed and mould-cast SHGCs. The underlying reasons for the differences are discussed.
Update on Interventional Management of Neuropathic Pain: A Delphi Consensus of the Spanish Pain Society Neuropathic Pain Task Force
Authors: Serrano-Afonso Ancor , Gálvez Rafael , Paramés Elena , Navarro Ana , Ochoa Dolores , Pérez-Hernández Concepción
Published: March 2022

Interventional management of neuropathic pain (NP) is available to the many patients who do not attain satisfactory outcomes with pharmacotherapy, but evidence supporting this is sparse and fragmented. We attempted to summarize and critically appraise the existing data to identify strategies that yield maximum benefit, orient clinicians, and identify areas that merit further investigation. A two-round Delphi survey that involved pain clinic specialists with experience in the research and management of NP was done over an ad hoc 26-item questionnaire prepared by the authors. Consensus on each statement was defined as either at least 80% endorsement or rejection after the second round. Thirty-five and 29 panelists participated in the first and second round, respectively. Consensus was reached in 20 out of 26 statements. There is sufficient basis to treat postherpetic neuralgias and complex regional pain syndromes with progressive levels of invasiveness and failed back surgery syndrome with neuromodulation. Radiculopathies and localized NP could be treated with peripheral blocks and neuromodulation, or pulsed radiofrequency. Non-ablative radiofrequency and non-paresthetic neuromodulation are efficacious and better tolerated than ablative and suprathreshold procedures. A graded approach, from least to most invasive interventions has the potential to improve outcomes in many patients with common refractory NP conditions. Preliminary promising data warrant further research on new indications, and technical advances might enhance the safety and efficacy of current and future therapies.
Reflectance at Visible Wavelengths for Biological and Biochemical Characteristics of Ocimum Basilicum - Practicability of Colour Sensors for Plant Phenotyping
Authors: Tran Trung Nam , Keller Rieke , Trinh Vinh Quang , Tran Khanh Quoc , Kaldenhoff Ralf
Published: March 2022

Modern agriculture demands for comprehensive information about the plant itself. Conventional chemistry-based analytical methods - due to their low throughput and high associated cost - are no longer capable of providing these data. In recent years, remote reflectance-based characterization has developed as one of the most promising solutions for rapid assessments for plant attributes. However, in many cases, expensive equipment is required because accurate quantifications need assessment of the full reflectance spectrum. We examined the versatility of visible colour sensors as reflectance measuring devices for biological / biochemical quantifications on sweet basil (Ocimum basilicum). Our results indicate for the wide potential of spectral colour sensors for quantitative determination of leaf phenolic compounds, flavonoids in particular, and non-invasive plant phenotyping in agricultural applications by low-cost sensors.
Mathematical model of radiation-induced conductivity in sapphire with electron-phonon interaction
Authors: Kanevskiy Vladimir Mikhaylovich , Tarakanov Ilya Alekseyevich , Fedorov Vladimir Anatol'yevich
Published: March 2022

The mathematical model of radiative conductivity in crystalline sapphire under the action of X-rays is constructed. The model consists of kinetic equations for photons, fast electrons and conduction electrons and self-consistent Maxwell equations. The frequencies of conduction electrons scattering by acoustic and optical phonons are calculated. The model was verified by calculating the leakage current in the sapphire detector and comparing the current with experimental data. The analysis of the calculated physical quantities and the approximations adopted in the course of the calculation is carried out.
Weather forecast estimation for planning of optical observations
Authors: Lopachenko Vladimir Vladimirovich , Mokhnatkin Artem Vitalevich , Voropaev Viktor Anatolevich
Published: March 2022

A method is proposed for the formation of a numerical criterion, which is a generalized characteristic of weather forecast taking into account features of optical observations. The proposed approach on weather forecast parameterization is used for planning optical observation on some telescopes coordinated by KIAM RAS.
JALUR DISTRIBUSI PRODUK BATIK DI KELURAHAN LAWEYAN, KOTA SURAKARTA
Authors: Sari Dian Pramita , Aliyah Istijabatul , Putri Rufia Andisetyana
Published: March 2022

Batik merupakan produk unggulan bagi Kota Surakarta. Salah satu kelurahan yang ditetapkan sebagai sentra batik di Kota Surakarta berdasarkan Surat Keputusan Walikota Surakarta Nomor 536/60 Tahun 2019 adalah Kelurahan Laweyan. Berdasarkan hasil interpretasi, Kelurahan Laweyan sebagai sentra batik memiliki dominasi aktivitas perdagangan dibandingkan dengan industri. Selama ini diketahui bahwa sentra batik di Kota Surakarta mampu memasarkan produknya hingga pasar global. Saluran distribusi memiliki peranan dalam memenuhi permintaan batik yang luas tersebut untuk terus berkembang dan meningkatkan perekonomian masyarakat setempat. Oleh karena itu, penelitian ini memiliki tujuan untuk mengetahui saluran distribusi produk batik dari produsen di Kelurahan Laweyan. Penelitian ini merupakan penelitian deduktif dengan teknik analisis deskriptif kuantitatif dan pemetaan. Data didapat dari menyebar kuesioner kepada lembaga distribusi batik di Kelurahan Laweyan, observasi, dan melakukan studi literatur pembahasan terkait yang dipublikasikan secara resmi. Temuan pertama menunjukkan bahwa secara garis besar, produsen batik di Kelurahan Laweyan terbagi menjadi dua jenis, yaitu produsen batik cap-tulis dan produsen batik printing. Temuan kedua adalah produsen cenderung terletak mengikuti Jalan Sidoluhur, selebihnya memiliki persebaran yang acak. Temuan terakhir, sebanyak 25% produsen batik printing di Kelurahan Laweyan menyalurkan produknya kepada konsumen saja, 75% lainnya menyalurkan produknya ke pedagang besar dan pengecer. Sedangkan, 86% produsen batik cap dan tulis  menyalurkan kepada konsumen saja, dan 14% lainnya menyalurkan produknya kepada konsumen dan pengecer. Sehingga, saluran distribusi yang terbentuk dari produsen batik di Kelurahan Laweyan adalah produsen – pedagang besar – pengecer – konsumen, produsen – pengecer – konsumen, dan produsen – konsumen. Secara keseluruhan, 53% wilayah yang menjadi tujuan produk batik dari produsen batik di Kelurahan Laweyan adalah Pulau Jawa, diikuti luar negeri sebanyak 35%, dan luar Pulau Jawa sebanyak 12%. Maka dapat disimpulkan bahwa produsen batik di Kelurahan Laweyan menggunakan saluran distribusi langsung, tidak langsung, dan campuran dengan wilayah pemasaran yang mendominasi berada di dalam Pulau Jawa.
KINERJA GURU DALAM LESSON STUDY (STUDI KASUS DI SMK N 2 SURAKARTA PADA MATA PELAJARAN MEKANIKA TEKNIK KELAS X BISNIS KONSTRUKSI DAN PROPERTI TAHUN AJARAN 2017/2018)
Authors: Munandar Abdul Wakhid Ali , Sumarni Sri , Sukatiman Sukatiman
Published: March 2022

Penelitian ini bertujuan untuk mengetahui pelaksanaan lesson study yang
dilaksanakan tim guru di SMK Negeri 2 Surakarta, dan untuk mengetahui kinerja guru dalam
penerapan lesson study yang dilaksanakan pada mata pelajaran Mekanika Teknik di kelas X
Bisnis Konstruksi dan Properti SMK Negeri 2 Surakarta. Subjek penelitian ini adalah guru
mata pelajaran Mekanika Teknik kelas X Bisnis Konstruksi dan Properti SMK Negeri 2
Surakarta. Pengumpulan data dilakukan dengan observasi, angket, dan dokumentasi. Analisis
data menggunakan teknik kualitatif dengan model analisis interaktif. Model ini terdiri dari
reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian adalah sebagai
berikut. Pertama, pelaksanaan lesson study di SMKN 2 Surakarta dilaksanakan oleh guru
mata pelajaran Mekanika Teknik dan observer yang dimulai dari tahap plan (perencanaan
pembelajaran) selanjutnya yaitu do (pelaksanaan pembelajaran) terakhir yaitu see (refleksi
hasil pembelajaran). Penerapan lesson study di SMKN 2 Surakarta dilaksanakan dengan
penambahan model pembelajaran Two Stray Two Stay (TSTS) dan Group Investigation (GI).
Kedua, Pelaksanaan lesson study dapat memperbaiki kinerja guru. Hal ini dapat dilihat pada
saat observasi awal, kinerja guru hanya mendapatkan skor 64,4% dari butir penilaian
sehingga kinerja guru masuk dalam kategori kurang. Setelah dilaksanakan lesson study
menghasilkan perbaikan nilai kinerja guru menjadi 71,8% dan masuk dalam kategori cukup
pada pelaksanaan pertama, kemudian terus membaik pada pelaksanaan kedua menjadi 78,6%
atau bisa dikategorikan dalam kategori baik.
PENGARUH SERBUK KERAMIK SEBAGAI PENGGANTI AGREGAT HALUS DAN ABU TERBANG (FLY ASH) SEBAGAI PENGGANTI 15% BERAT SEMEN TERHADAP KUAT TARIK BELAH DAN POROSITAS PADA BETON
Authors: Sekarini Dwitami , Sunarsih Ernawati Sri , Siswanto Budi
Published: March 2022

Tujuan penelitian ini adalah, untuk mengetahui (1) pengaruh variasi serbuk
keramik sebagai pengganti agregat halus dan pengaruh abu terbang (fly ash)
sebagai pengganti 15% dari berat semen terhadap kuat tarik belah beton, (2)
pengaruh variasi serbuk keramik sebagai pengganti agregat halus dan pengaruh
abu terbang (fly ash) sebagai pengganti 15% dari berat semen terhadap porositas
beton. (3) persentase penggunaan serbuk keramik sebagai pengganti agregat halus
yang optimum untuk menghasilkan kuat tarik belah maksimum pada beton. (4)
persentase penggunaan serbuk keramik sebagai pengganti agregat halus yang
optimum untuk menghasilkan porositas minimum pada beton. Penelitian ini
menggunakan metode kuantitatif eksperimen. Analisa data menggunakan uji
regresi, dengan melakukan uji prasyarat normalitas, homogenitas, dan linearitas
dengan bantuan program SPPS 16.0. Variabel yang terdapat pada penelitian ini
adalah (1) Variabel terikat : kuat tarik belah dan porositas beton , (2) Variabel
bebas : variasi serbuk keramik sebagai pengganti agregat halus pada beton.
Keseluruhan anggota populasi yang menjadi sampel penelitian ini adalah 40
sampel. Benda uji berupa silinder berdiametert150 mm dengan tinggi 300 mm,
dan silinder dengan diameter 50,8 mmtdan tinggi 50 mm. Berdasarkan hasil
penelitian dapat disimpulkan bahwa, (1) adanya variasi serbuk keramik sebagai
pengganti agregat halus dan 15% fly ash sebagai pengganti semen, berpengaruh
signifikan sebesar 74,1% terhadap kuat tarik belah beton. (2) Adanya variasi
serbuk keramik sebagai pengganti agregat halus dan 15% fly ash sebagai
pengganti semen, berpengaruh signifikan sebesar 51,5% terhadap porositas beton.
(3) Kuatttariktbelah maksimal sebesar 2,75 Mpa pada variasi serbuk keramik
optimum sebesar 6,214%. (4) Porositastminimum sebesar 12,33% pada variasi
serbuk keramik optimum sebesar 15%.
PENGEMBANGAN E-VOCATIONAL SEBAGAI MEDIA PEMBELAJARAN BERBASIS VIDEO TUTORIAL MENGGAMBAR ALINEMEN JALAN RAYA
Authors: Saputra Raka Agustian , Sukatiman Sukatiman , Saputro Ida Nugroho
Published: March 2022

Penelitian ini bertujuan untuk: 1) mengembangkan e-vocational sebagai
media pembelajaran berbasis video tutorial dengan materi menggambar alinemen
jalan raya pada mata kuliah Gambar Konstruksi Jalan, Jembatan dan Bangunan
Air; 2) mengetahui tingkat kelayakan E-Vocational sebagai media pembelajaran
berbasis video tutorial menggambar alinemen jalan raya pada mata kuliah Gambar
Konstruksi Jalan, Jembatan dan Bangunan Air. Penilitian pengembangan EVocational terdiri dari 8 tahap yaitu: 1) studi literatur dan observasi proses
pembelajaran; 2) pembuatan desain media; 3) validasi desain; 4) uji kelompok
kecil; 5) revisi desain; 6) uji kelompok luas; 7) revisi desain; 8) evaluasi dan
penyempurnaan. Populasi pada penelitian ini adalah mahasiswa Pendidikan
Teknik Bangunan Universitas Sebelas Maret angkatan 2014 dan 2015 yang telah
lulus mata kuliah Gambar Konstruksi Jalan, Jembatan dan Bangunan Air. Teknik
angket digunakan untuk pengumpulan data validasi desain dan uji coba pengguna.
Analisis data yang digunakan adalah statistik deskriptif, data diperoleh dari
katagori kelayakan E-Vocational berdasarkan skor kriteria likert. Hasil penelitian
disimpilkan bahwa: 1) e-vocational sebagai media pembelajaran berbasis video
tutorial dengan materi menggambar alinemen jalan raya pada mata kuliah Gambar
Konstruksi Jalan, Jembatan dan Bangunan Air telah berhasil dikembangkan
melalui tiga tahap yaitu tahap pendahuluan, tahap pengembangan dan tahap
pengujian. 2) Persentase kelayakan sebesar 85,83% menyatakan media EVocational termasuk dalam kategori sangat layak, ditinjau dari aspek umum,
aspek komunikasi visual, aspek rekayasa perangkat lunak, aspek desain
pembelajaran.
MODIFIKASI CAMPURAN ASPAL DENGAN BAHAN TAMBAH LIMBAH GELAS PLASTIK (POLYETHYLENE TEREPHTHALATE / PET) DITINJAU PADA ASPEK STABILITAS DAN KELELEHAN PLASTIS
Authors: Wahyu Indrasto Imam Wegik , Suprimurtiono Eko , Nurhidayati Aryanti
Published: March 2022

Tujuan dari penelitian ini yaitu untuk mengetahui pengaruh penambahan limbah gelas plastik PET terhadap stabilitas dan flow aspal. Penelitian ini merupakan penelitian kuantitatif. Subjek penelitian ini adalah campuran aspal dengan penambahan limbah gelas plastik PET sebanyak 0%, 1%, 3%, 5%, dan 7% dari berat aspal. Teknik pengumpulan data menggunakan metode eksperimen dengan pengujian di laboratorium. Hasil penelitian ini menunjukkan bahwa penambahan limbah gelas plastik PET berpengaruh signifikan terhadap stabilitas aspal dengan stabilitas optimal ada pada penambahan 3% dan stabilitas 1270,8 Kg. Penambahan limbah gelas plastik PET juga berpengaruh signifikan terhadap flow. Nilai flow pada campuran aspal dengan bahan tambah bersifat linier, sehingga semakin
banyak penambahan maka semakin tinggi pula nilai flow yang didapat.
PERILAKU KEGAGALAN GESER PADA BALOK LAMINASI JABON-BAMBU
Authors: Rahmawati Kundari , Sunarsih Ernawati Sri , Roemintoyo Roemintoyo
Published: March 2022

The development of engineering timber technology such as laminated veneer lumber, cross-laminated timber, and others proposes to satisfy the timber demand deficit in terms of both strength and material dimensions. In addition to being green and sustainable, timber has a higher mass strength ratio than concrete or steel materials. Jabon (Anthocephalus cadamba Miq.) is fast-growing species of timber produced by community plantations commonly used for furniture. Jabon timber including classified as strength timber IV causes this type of timber is not used as a structural element. To increase the strength of Jabon wood, researchers assembled the timber with Petung bamboo  (Dendrocalamus asper) which mechanically has a better toughness. This is what underlies the researchers made an innovation to make the timber laminated beam of bamboo-Jabon. The purpose of this research was to determine the mechanical behavior of bamboo-Jabon lamination due to shear failure. The method used in this study is experimental. The dimensions of the beam in this research are 60 x 120 mm with a length of 900 mm, a static bending test is performed. There are three variations in this research, namely variations in the thickness of timber slabs 10 mm, 15 mm, 20 mm, and bamboo thickness of 5 mm. The results of this research show that the shear stress of the laminated beam experimental results of jabon-bamboo is 1.9 times, 1.67 times, 1.71 times greater compared to the analysis of sequential appearance transformations for the thickness variation of 10 mm, 15 mm, and 20 mm. When compared with the analysis using SNI 7973:2013, the jabon-bamboo laminate beam has a greater shear stress value of 1.89 times, 1.45 times, and 1.31 times respectively for variations in the thickness of the blade of jabon timber 10 mm, 15 mm, and 20 mm.
Comparison of Item Response Theory Scaling Methods with ROC Analysis
Authors: YURTÇU Meltem , GÜZELLER Cem
Published: March 2022

In this study, one-dimensional item response theory models were evaluated using different scaling methods. In this context, the equating errors and the area under the curve of four scaling methods (Stocking-Lord, Heabara, Mean-Sigma, Mean-Mean), and one, two, and three parameters logistic models (1PL, 2PL, and 3PL) in non-equivalent groups with anchor test (NEAT) design were examined. Additionally, the equating errors of the scaling methods and the results obtained from ROC analysis were compared. Qatar's and Australia's PISA 2012 mathematical literacy test data were used in the study. The minimum error was obtained from the Mean-Mean method with the 1PL model, and the maximum error was obtained from the Mean-Mean method with the 3PL model. Similar results were observed in all comparisons and supported each other. It is concluded that ROC analysis can be used to compare different conditions, methods and models.
Investigating the Effect of Item Position on Person and Item Parameters: PISA 2015 Turkey Sample
Authors: DEMİRKOL Sinem , KELECİOĞLU Hülya
Published: March 2022

Different positions of items in booklets affect the probabilities of correct answers. This effect is called the item position effect in the literature, which causes variances in the item and person parameters. The aim of this study is to investigate the item position effect within the framework of explanatory item response theory. The analyses of this research were carried out on the PISA 2015 Turkey sample, and the item position effect was examined in the domains of reading and mathematics. In addition, the effect of the item position in different item formats (open response and multiple choice) was investigated. According to the results, the item position effect decreased the probability of answering the item correctly, and this effect was higher in reading than in mathematics. Furthermore, in the domain of mathematics, open response items were affected more than multiple-choice items by the item position. In the reading domain, open response and multiple choice items were affected similarly. The results of the analysis show that there were undesirable effects of the item position, and these effects should be taken into account.
Contribuições para o avanço da Economia da Saúde no Sistema de Saúde Brasileiro
Authors: Macêdo Everton , Castro Marcelo , Silva Maciene , Trigueiro Wesley
Published: March 2022

Artigo Institucional
The Impact of Sulfate-Driven Anaerobic Oxidation of Methane on the Carbon Isotopic Composition in Marine Sediments: A Case Study from Two Sites in the Shenhu Area, Northern South China Sea
Authors: Wang Bin , Lei Huaiyan , Huang Fanfan , Kong Yuan , Yin Xijie
Published: March 2022

Authigenic carbonate in seep environments, as a direct byproduct of sulfate-driven anaerobic oxidation of methane (SD-AOM), is usually absent within the sediment column because of the requirement of a strict formation condition. In this case, the lack of a reliable carbon signal may impede the identification of SD-AOM and methane leakage. Here, carbon and oxygen isotopes, elemental compositions, AMS 14C dates in sediments, and porewater geochemistry were investigated from two sites (A27 and SH1) of the Shenhu area, northern South China Sea (SCS), to discuss how SD-AOM affects the carbon isotope in methane-affected marine sediments. Porewater results at both sites indicate the occurrence of methane diffusion from the sulfate-methane transition zone (SMTZ) below. The carbon isotopes of bulk-sediment carbonate and foraminifera show no distinctly negative excursion, reflecting that these signals are invalid in response to SD-AOM in the investigated sites. Then, a mass balance model is adopted to evaluate the δ13C value of authigenic carbonate (δ13CAC). Consequently, three intervals (A2 and A3 from site A27 and S2 from site SH1) are identified, featuring negative δ13CAC values, high TS/TOC ratios, and enhanced contents of authigenic carbonate, which are most likely influenced by SD-AOM. Considering the current SMTZ located at deeper layers, intervals A2 and S2 represent the locations of paleo-SMTZ, while interval A3 is thought to be influenced by the current methane diffusion. Interestingly, the δ13C values of total organic matter (δ13CTOC) show positive excursions within the paleo-SMTZs, which can be explained herein by the diagenetic modification. In the course of SD-AOM at the SMTZ, high rate of (methylotrophic) methanogenesis preferentially consumes lighter carbon atoms in organic matter, with the remainder being gradually more positive. Our results indicate that the exploration of a reliable methane-carbon response in systems lacking seep carbonates plays an important role in constraining SD-AOM and methane release.
Heat Generation and Accumulation for Hot Dry Rock Resources in the Igneous Rock Distribution Areas of Southeastern China
Authors: Lin Wenjing , Wang Guiling , Gan Haonan , Wang Andong , Yue Gaofan , Long Xiting
Published: March 2022

Hot dry rock (HDR) is an important geothermal resource and the primary direction of future geothermal development. Granite is particularly rich in radiogenic heat-generating elements (e.g., U, Th, and K) and is thus the main target for HDR development worldwide. Southeastern China contains the most abundant granite distribution in the country and accounts for more than 40% of the total granite area. This paper analyzes the rock radiogenic heat production, geothermal flux, crustal thermal structure, and reservoir temperature in the key exploration areas based on a systematic investigation of the distribution of granite resources and their heat generation characteristics. A heat generation and accumulation model of HDR resources is proposed for southeastern China. The results show that southeastern China can be characterized by a quadratic heat gathering model that includes a mantle source heat supply, intracrustal heat generation, fracture heat transfer, and cover heat preservation. Among these, the radiogenic heat production of granite is one of the main factors that affects shallow geothermal fields in this region. Fracture structure and cover conditions also exert a strong control on the gathering and dissipation of underground heat. The widely distributed and high-heat-producing tuffs and fused tuffs in the Zhangzhou area offer promising heat-generating and heat-gathering conditions for future exploration and development of hot dry rock resources in the area. The results provide important insight on the genesis and heat control factors of HDR resources in southeastern China and a theoretical reference for future HDR resource exploration and development practices in the region.
HSP90AA1 promotes the inflammation in human gingival fibroblasts induced by Porphyromonas gingivalis lipopolysaccharide via regulating of autophagy
Authors: Zhang Huang , Huang Jie , Fan XuSheng , Miao RuiJing , Wang YongWu
Published: March 2022

Background
Peri-implantitis of tooth seriously affects the life quality of patients. This study aims to investigate the role of HSP90AA1 in the inflammatory of human gingival fibroblasts (HGFs) induced by porphyromonas gingivalis lipopolysaccharide (Pg-LPS), and to provide a potential therapeutic target for clinical treatment of peri-implantitis.
Methods
Used Pg-LPS (0.1, 1, 10 µg/mL) to construct an inflammatory model of HGFs, and transfected HSP90AA1-siRNA to construct HSP90AA1 low expression HGFs cell line, respectively. After that, cell viability, the contents of IL-1β, IL-6, TNF-α were detected by CCK-8, and ELISA assay. Intracellular ROS, the expressions of HSP90α, HSP90β were detected by immunofluorescence. Apoptosis was detected by flow cytometry. Western blot, RT-PCR detected the protein and gene level of HSP90AA1, and relative protein expressions of p-NF-κB p65/NF-κB p65, LC3 II/I, ATG5, and Beclin-1 was detected by western blot.
Results
In the inflammatory cell model, compared with the control group, Pg-LPS did not affect cell viability, increased the contents of IL-1β, IL-6, and TNF-α in cells, and increased protein, gene level of HSP90AA1, and p-NF-κB p65/NF-κB p65, LC3 II/I, ATG5, Beclin-1 protein levels. In HGFs cell line with low expression of HSP90AA1, compared with siNC group, the levels of inflammatory factors, ROS, apoptosis rate, HSP90α, HSP90β protein expression, and autophagy related protein levels in siHSP90AA1 group were significantly reduced.
Conclusions
This study confirmed that HSP90AA1 gene promotes Pg-LPS induced HGFs inflammation mediated by autophagy in vitro. It is suggested that HSP90AA1 is a key gene in the development of peri-implantitis.
An Investigation Into the Knowledge, Attitude and Predictors of Safe Abortion Among Female Students in the Eastern Cape, South Africa
Authors: Mutinta Given
Published: March 2022

Background Safe abortions are performed throughout the world. In South Africa, abortion is legal but over half of abortions remain unsafe and there is a dearth of studies on safe abortion among students. The aim of this study was to investigate into the knowledge, attitude, and predictors of safe abortion among female students in the Eastern Cape Province, South Africa. MethodsThe study was guided by a cross-sectional research design and underpinned by quantitative methodology. A self-administered questionnaires was used to collect data from female students selected using a multi-stage sampling method. Data was analysed using SPSS version 24, and bivariate and multivariable logistic regression was performed to determine the association of dependent and independent variables.ResultsData was collected from 1266 female students with the response rate of more than 100%. The study found that 866 (68.5%) of the students had good knowledge about safe abortion. Having ever heard about safe abortion (AOR = 4.37, 95% CI: 1.89, 10.84), older age (AOR = 2.79, 95% CI: 1.17, 7.29), family education (AOR = 3.19, 95% CI: 1.33, 7.07), and urban habitation (AOR = 2.43, 95% CI: 1.27, 4.36) were predictors of students’ knowledge of safe abortion. Findings show that 722 (57%) of students had favourable attitude towards safe abortion. Staying in an urban area (AOR = 1.52, 95% CI: 1.10, 2.22), and age (AOR = 6.59, 95% CI: 2.72, 11.22) were found to be significant predictors of students’ attitude towards safe abortion. ConclusionThe study revealed that half of the students had good knowledge and attitude towards safe abortion while a significant proportion had poor knowledge and unfavourable attitude. Findings show that having ever heard about abortion, residence, age of students, and family education were predictors of knowledge on safe abortion. In addition, age and residents were predictors of students’ attitude towards abortion. There is need for health communication and education programmes to address the subject of safe abortion among students. Health communication and education programmes should target students from rural areas and employ age-specific programmes. Government should provide youth-friendly reproductive services to the rural areas of South Africa.
Community views on medication use in fragile X syndrome
Authors: Eley Sarah , McKechanie Andrew G. , Stanfield Andrew C.
Published: March 2022

Objectives
The difficulties inherent in conducting clinical trials in fragile X syndrome (FXS) mean that investigators must be judicious in selecting which potential therapeutic interventions to trial. To inform the development of future trials we set out to examine what the attitudes of families are to taking medication, and to participating in medication trials, including what their priorities for intervention are.
Results
Seventy three people completed the questionnaire. The majority reported being interested in taking part in medication trials. Over 50% of respondents were either unaware or had no opportunity to participate in trials. The priorities for future trials were anxiety, learning, language, attention and social behaviour. Attention was more commonly listed as a priority for children, whereas social behaviour was more common in adults.
Catalytic-independent function of PARP-1 is essential in regulating human islet-cell differentiation from stem cells
Authors: Dadheech Nidheesh , Srivast Abhay , Shah Rashmi G. , Shah Girish M. , Gupta Sarita
Published: March 2022

Poly (ADP) Ribose Polymerase-1 (PARP-1), a fundamental DNA repair enzyme is known to regulate β cell death, replication, and insulin secretion. PARP-1 knockout (KO) mice are resistant to diabetes while PARP-1 overactivation contributes to β cell death. Additionally, PARP-1 inhibition improves diabetes complications in patients with type-2 diabetes. Despite these beneficial effects, the use of PARP-1 modulating agents in diabetes treatment are largely neglected, primarily due to the poorly studied mechanistic action of PARP-1 catalytic function in human β cell development. In the present study, we evaluated PARP-1 regulatory action in human β cell differentiation using the human pancreatic stem cell line, PANC-1. We surveyed islet census and histology from PARP-1 wild-type versus KO mice pancreas in head-to-head comparison with PARP-1 regulatory action for in-vitro β cell differentiation following either PARP-1 depletion or its pharmacological inhibition in PANC-1-differentiated islet cells. shRNA mediated PARP-1 depleted (SiP), or control replete (U6) PANC-1 cells were differentiated into islet-like clusters using established protocols. We observed complete abrogation of new β cell formation with absolute PARP-1 depletion while its catalytic inactivation using the strong inhibitor, PJ34, promoted the endocrine β cell differentiation and maturation. Immunohistochemistry and proteomics for key endocrine differentiation factors in addition to β cell maturation markers highlighted potential regulatory and augmented β cell differentiation due to non-catalytic function of PARP-1 elicited p-38 MAPK phosphorylation and Neurogenin-3 (Ngn3) re-activation. In summary, the study reestablishes a novel ability of catalytic independent action of PARP-1 in regulating islet cell differentiation and potential avenues for pilot clinical testing of PARP-1 inhibitors for β cell replacement therapies for the treatment of diabetes.
CASPR2 Neurological Autoimmunity in Children
Authors: Wu Liwen , Cai Fang , Zhuo Zhihong , Wu Dejun , Zhang Tianyi , Yang Haiyang , Fang Hongjun , Xiao Zhenghui
Published: March 2022

Objective
To identify the clinical features of CASPR2 neurological autoimmunity in children and to strengthen the understanding of the disease for developing diagnosis and treatment strategies.
Methods
A multicenter retrospective analysis and prospective observation of CASPR2 autoimmunity in the past 7 years was conducted.
Results
Twenty-six anti-CASPR2-positive patients were enrolled in this study, including 25 with serum positivity and 3 with cerebrospinal fluid (CSF) positivity (2 patients with both serum and CSF positivity); 3 patients were co-positive with anti-NMDAR antibody and 1 was copositive with anti-GABABR antibody. Eleven patients (6 manifesting with refractory epilepsy, 4 manifesting with psychobehavioral abnormalities and 1 accompanied with germinoma) presented with low antibody titers, relatively normal MRI/EEG/CSF examinations, and poor response to immunotherapy and were thus considered false positive (42.3%). Fifteen patients were diagnosed with anti-CASPR2-related neurological autoimmunity: 10 with autoimmune encephalitis (including 2 manifested as Morvan syndrome and 1 whose condition was secondary to Japanese encephalitis), 4 with typical clinical features of autoimmune encephalopathy, and 1 with autoimmune cerebellitis. The most common symptoms included disorders of consciousness (10/15), fever (8/15), psychological symptoms/abnormal behaviors (8/15), sleep disorders (8/15), seizures (7/15), movement disorders (5/15), autonomic symptoms (5/15), peripheral nerve hyperexcitability/neuromyotonia (5/14) and weakness/hemiplegia (4/15). Brain MRI revealed abnormalities in 10 patients (66.7%). The most common sites of lesions were the cerebral cortex (6/15, widely distributed across the frontal, parietal, occipital and temporal lobes) and thalamus (5/15). Electroencephalography (EEG) recordings revealed a slow wave background in 13 patients (86.7%). Five of 15 patients showed elevated WBCs in the CSF, and 4 of 15 patients showed elevated protein levels in the CSF. Thirteen patients received immunotherapy (rituximab was adopted in 2 cases) and recovered well. Two patients received symptomatic treatment, and the recovery was slow and accompanied by emotional abnormalities and developmental delay.
Conclusions
CASPR2 autoantibody disease is not very rare in children and can occur in infancy. The most common clinical phenotypes of CASPR2-related autoimmunity were encephalitis phenotype, including Morvan syndrome and cerebellar ataxia. We also first reported a case of autoimmune encephalitis secondary to Japanese encephalitis. The prognosis of this disease is good, and rituximab can be used in patients who respond poorly to conventional immunotherapy. The high false-positive rate of anti-CASPR2 in refractory epilepsy and the psychobehavioral abnormalities needs to be explored further.