bluuebunny/crossref_metadata_2025 huggingface dataset:
Enantioselective Energy Transfer-Enabled Cyclization using a Privileged Al-Salen Photocatalyst
Authors: Soika Julia , Onneken Carina , Wiegmann Thorben , Morack Tobias , Lindfeld Leander , Hebenbrock Marian , Mück-Lichtenfeld Christian , Neugebauer Johannes , Gilmour Ryan
Published: October 2024

Chiral catalysts that can engage multiple substrates, via distinct activation modes, to deliver enantioenriched products with high levels of fidelity are often described as “privileged”. Antipodal to enzymatic specificity, this generality enables the reactivity - selectivity divide in ground state landscapes to be effectively reconciled. Achieving this latitude in excited state paradigms remains a frontier, and efforts to identify privileged chiral photocatalysts are currently a core area of research. Aluminum salen complexes are emergent contenders on account of their well-defined photophysical properties and competence in photo-induced single electron transfer processes: this has recently been leveraged in the deracemization of cyclopropyl ketones. To expand the activation repertoire of Al-salen photocatalysts, an unprecedented enantioselective energy transfer (EnT) catalysis-enabled photocyclization of acrylanilides has been developed. This operationally simple strategy allows reactivity and enantioselectivity to be simultaneously regulated by an inexpensive, commercial chiral Al-salen complex upon irradiation at λ = 400 nm: this allows diverse cyclic products to be forged with high levels of enantioselectivity (up to 96:4 e.r.). Establishing this dichotomy in excited state activation modes serves to consolidate the privileged status of chiral Al-salen complexes in enantioselective photocatalysts and to complement their ubiquity in ground-state regimes.
Rational design of small-molecule peptidomimetics for three pivotal protein secondary structures
Authors: Yoo Jeong Yeon , Kim Chan Woo , Kwon Ji Hoon , Cho Hana , Jeong Ki Young , Park Won woo , Kim Young Hoon , Lee Dong Hwan , Park Seung Bum
Published: October 2024

In the pursuit of modulating protein-protein interactions (PPIs) using small molecules, the lack of studies addressing PPI modulation without structural information presents a significant hurdle. Although peptides have been utilized for this purpose, challenges such as permeability and stability persist, emphasizing the necessity for innovative small- molecule modulators. To target unexplored PPIs, we introduced a computational method encompassing three essential secondary structures of peptidomimetic scaffolds—α-helix, β- strand, and β-turn—serving as key recognition motifs for protein-protein interfaces. These scaffolds (1–3), systematically derived from a single pyrimidodiazepine skeleton, demonstrated precise alignment with each secondary structure, validated through in-silico analysis and X-ray crystallography. Subsequently, our pyrimidine-containing peptidomimetic scaffolds underwent rigorous evaluation via diverse phenotypic screenings. Positioned as invaluable chemical tools, these scaffolds hold immense potential for discovering novel PPI modulators. Our design strategy offers a rational approach, overcoming the inherent pharmacokinetic and pharmacodynamic limitations of traditional peptides. By leveraging structures and drug-like properties of small molecules, we aim to pioneer a new era in the design and synthesis of effective PPI modulators.
Nickel (II) Complexes Bearing Electron Donating OR/OH Groups on a Tetradentate Ligand Scaffold for Photocatalytic Carbon Dioxide Reduction
Authors: Manafe Sonya , Olajide Gbolagade , Boudreaux Chance , Qu Fengrui , Whitt Logan , Pridemore Patrick , Hall James Fletcher , Szilvasi Tibor , Papish Elizabeth
Published: October 2024

Nickel (II) complexes bearing tetradentate NCCN ligands comprised of optionally protic pyridine and N-heterocyclic carbene (NHC) donors have been synthesized and used as catalysts for carbon dioxide reduction. These complexes were synthesized bearing OMe, OBn, or OH substituents on the pyridine rings and were characterized by 1H NMR, 13C NMR, UV-Vis, IR, HR-MS, and single crystal X-ray diffraction. The OH substituent was partially deprotonated as shown by the crystal structure. Electrochemical studies show that these nickel complexes undergo two electron reduction events prior to CO2 reduction. Catalytic current enhancement under CO2 relative to N2 is not observed under dry conditions, but the addition of proton sources leads to modest current enhancement (icat/ip < 2). Visible light driven photochemical CO2 reduction with a photosensitizer (Ir(ppy)3 where ppy = 2-phenylpyridine) and sacrificial electron and proton donors was studied, and formate is the major product with ~10:1 formate to CO production. Electron donor groups (OMe, OBn, OH) do not enhance formate production (relative to H analog), and CO production is only slightly enhanced. Overall with Ni(II), the tetradentate ligands are comparable to recently published pincer ligands for sensitized CO2 reduction, but pincer ligands offer a clear advantage in self-sensitized catalysis.
Lessons learned in autoclave synthesis of upconversion nanoparticles: unreported variables and safety considerations
Authors: McGonigle Rebecca , Glasgow Jodie , Houston Catriona , Cameron Iain , Homann Christian , Black Dominic , Pal Robert , MacKenzie Lewis
Published: October 2024

Autoclaves are widely used across chemical and biological sciences, including for synthesis of nanomaterials at elevated temperature and pressure, such as upconversion nanoparticles (UCNPs). Yet, the details of how autoclave reactors used in such synthesis are poorly reported in the literature, leaving several key synthesis variables widely unreported and hampering reproducibility, both for UCNP research, and wider nanomaterial synthesis. In this perspective, we discuss the safety considerations of autoclave reactors and note that autoclaves should only be used if they are (a) purchased from reputable suppliers/manufacturers and (b) have been certified compliant with relevant safety standards. Ultimately, using unsuitable autoclave equipment can pose a severe physical hazard and may breach legal safety requirements. In addition, we highlight several parameters in autoclave synthesis that should be reported as standard to maximise the reproducibility of autoclave synthesis experiments across materials and chemistry research. We encourage users of autoclave synthesis vessels to: (a) adopt high-safety autoclaves and (b) report the many experimental variables involved to enhance experimental reproducibility.
Signatures of Band-like Optical and Charge Transport in Ti3C2Tx MXene Flakes
Authors: Fang Hui , Fang Zhenyao , Thakur Anupma , Anasori Babak , Rappe Andrew M. , Fakhraai Zahra
Published: October 2024

MXenes are promising materials for various electronic and optoelectronic applications. However, the understanding of MXene optical properties and charge transport mechanisms remains rather incomplete. Here, we demonstrate that the photon absorption in the near-IR region (≈1.5 eV) in titanium carbide Ti3C2Tx MXenes is due to the inter-band transition of the oxygen terminations, rather than a localized surface plasmon resonance. This peak shifts to higher energy as the film thickness is increased and the trapped water is removed. We provide a unifying picture of charge transport in monoflake and multiflake MXenes. We show that in both monoflake and out-of-plane direction of multiflake Ti3C2Tx MXenes, charge transport is predominantly band-like. In multiflake MXenes, however, in-plane charge transport is governed by thermally activated interflake hopping, which is facilitated by the presence of trapped water. We also demonstrate that surface plasmon propagation on MXene surfaces can strongly depend on the termination state and is hindered by strong loss in experimentally prepared mixed terminated MXenes. Our results reconcile previous debates and shed light on both optical properties and charge transport mechanisms in Ti3C2Tx MXenes, opening avenues for further exploration in electronic and optoelectronic applications.
Dynamic site-interconversion reduces the induction period of methanol-to-olefin conversion
Authors: Omojola Toyin
Published: October 2024

Reaction-diffusion coupling across the catalyst pore (active sites, catalyst surface), grain, pellet and reactor bed has been studied using a combination of theoretical concepts, and a particle-resolved transient microkinetic model applied to temperature-programmed desorption (TPD), and step response studies of methanol, and dimethyl ether conversion over ZSM-5 catalysts. TPD profile resolution shows coupling between adsorption, desorption, and diffusion across scales. Six models (coverage, anomalous diffusion, mass transfer of gas, and adsorbed phase, fixed site-interconversion, and dynamic site-interconversion) are investigated to describe the 44-min induction period in the first step-response cycle and the 95% reduction in induction period in subsequent cycles of dimethyl ether conversion. For the first time, we show that the reduction in induction period is not due to a zeolite-occluded pool (or coverage) effect. Dynamic interconversion across three site ensembles allows for the prediction of the induction period of propylene formation. Adsorption, desorption, and surface reaction of dimethyl ether occurs alongside with competitive adsorption of water and methanol leading to stable intermediates that produce propylene. The reduction in induction period is due to an autocatalytic transformation between three different reactive site ensembles. The first site ensemble retains the kinetic function of the first step response cycle while the second and third site ensemble adopt a new kinetic function due to transformation conveyed by surface methoxy species. The dynamic site interconversion model agrees with results from temperature-programmed surface reaction studies and are tenable for understanding the reduction in induction period and increasing the process efficiency particularly during start-up and steady-state conversion of methanol to olefins.
ROLE OF POLYMERIC MEMBRANE FOR WASTEWATER TREATMENT
Authors: Fatima Noor , Kumar Jai , Mather Hamza , Safdar Faiza , Mumtaz Faisal
Published: October 2024

Hazardous water contamination is a rising concern for the provision of usable and drinkable water to the world. Innovative, economic, and renewable technologies are the need of the hour for wastewater treatment. Several technologies have been reported to encourage wastewater treatment, such as ion exchange, co-precipitation, adsorption, membrane separation, oxidation, biochemical processes, etc. Among them, membrane separation technology has been considered a promising approach due to its short route and viable economics. Polymeric membrane-based technology comes with ease of functionalization, high sustainability, excellent adsorption, economic advantage, and environmental friendliness. That’s why, membrane processes were further developed to different separation mechanisms such as microfiltration (MF), ultrafiltration (UF), nanofiltration (NF), and reverse osmosis (RO). Herein, we report a mini review of polymeric membrane-based separation technology for wastewater treatment. The short communication includes the need for water purification and their purification by membrane technology, especially polymeric derived membranes. Besides, the state-of-art membrane and its utilization for the removal of various water contaminants were discussed. The proposed review would be helpful to provide a single platform to study about the role of polymeric membrane.
GENERATING RATING CURVE AND RATING TABLE OF GOLARCHI MINOR
Authors: Shah Shoukat Ali , Kiran Madeeha , Qasim Komal
Published: October 2024

Hydrologists must have huge theoretical and practical knowledge of irrigation networks such as rivers, canals, streams, channels, and minors. Because whole irrigation system relies on a gauge and discharges relationship which is essential for controlling floods, water resource management, and hydrologic modeling. The true and consistent figures of flow rate in the irrigation system are important for irrigation water efficiency. Mostly, Hydrologic modeling activities like hydraulic structures, designs, and management of surplus water in canals are subjected to the flow of irrigation water which is derived from the rating curve (RC). The managing of irrigation water in the system must be essential for crop water requirements and estimation of seepage losses. Thus, to fulfill the objectives, field activities (discharge measurement) were conducted in Golarchi minor of the Left-bank area water board. The main target was to calculate real discharge at different gauge levels and to develop a rating curve and rating table for the accurate distribution of irrigation water in the command area. Hence, the discharge was measured with a current meter and the area velocity method was employed for flowing water. The discharge was taken at three different gauges i.e., 1.2ft, 1.34ft, and 1.55ft with the discharge of 51.921cusecs, 55.021cusecs, and 58.197cusecs. Then collected data was exported to MS Excel for manipulation and for developing rating curves. The power equation was developed for Golarchi minor for confirming the different discharges on different gauge heights. The results of the study calculated as 1.1ft gauge to 1.7ft gave discharge 50.383cusecs to 61.009cusecs. It is concluded that the present study suggested that there should have an automatic gauging station to know the real demand for irrigation water in the command area and di-siltation should be done.
ASSESSMENT OF GROUNDWATER POTENTIAL AND AQUIFER VULNERABILIY USING MCDA AND DRASTIC ANALYSIS WITHIN AKURE METROPOLIS, SOUTHWESTERN NIGERIA
Authors: O. Olomo Kazeem , K. Olaleye Oluwatoyin , O. Ale Temitayo , I. Ibileke Jonathan , O. Ilugbo Stephen
Published: October 2024

Groundwater potential and aquifer vulnerability in some part of Akure metropolis southwestern Nigeria was carried out, using electrical resistivity survey, to identify and determine possible areas for groundwater development and its aquifer vulnerability. Geoelectric parameters from electrical resistivity survey helped in characterizing, assessing and evaluating the hydrogeological condition of aquifers in the area. A way of integrating all aquifer parameters significant to evaluating the groundwater potential and vulnerability, using the principle of Drastic and Multi-Criteria Evaluation Techniques, was proposed. The investigated area was classified into low, moderate and high groundwater prospect and aquifer vulnerability using the proposed method. The approach allows the weighting and integrating of all aquifer parameters in order of their significance to aquifer vulnerability. Integration of geophysical method with the proposed data management method provided a cost effective, dependable and accurate characterization and evaluation of an aquifer system.
Pengaruh Penambahan Kunyit (Curcuma domestica Val.) dan Baking Powder terhadap Karakteristik Stick Tepung Terigu-Garut
Authors: Pujimulyani Dwiyati , Hanifah Dika Nur , Setiyoko Agus
Published: October 2024

Kunyit memiliki potensi dalam pangan fungsional karena mengandung sifat antioksidatif yang berasal dari senyawa kurkuminoid. Oleh karena itu, kunyit ditambahkan pada stick ditambahkan yang merupakan camilan digemari oleh masyarakat. Stick dibuat dari campuran tepung terigu dan tepung garut, maka dari itu perlu ditambahkan baking powder untuk membentuk tekstur stick agar lebih renyah. Metode penelitian ini dilakukan menggunakan rancangan acak lengkap faktorial dengan 2 faktor dengan penambahan bubuk kunyit dengan variasi 5, 10 dan 15 g dan baking powder dengan variasi 0,15 g, 0,30 g, dan 0,45 g. Penambahan bubuk kunyit dan baking powder berpengaruh terhadap tingkat kesukaan, warna (lightness, redness dan yellowness), tekstur dan kadar air. Berdasarkan tingkat kesukaan stick terigu-garut terbaik dihasilkan dengan penambahan bubuk kunyit 5 g dan baking powder 0,30 g yang berturut memiliki sifat kimia kadar protein sebesar 8,48% (b/b), aktivitas antioksidan 53,82% RSA (DPPH) dan 5,64 mg E Fero/g (FRAP) serta kadar fenol total 20,88 mg EAG/g.
Substitusi Tepung Beras-Pati Garut dan Penambahan Ekstrak Bunga Telang (Clitoria ternatea) terhadap Karakteristik Cendol
Authors: Rani Amalianti Dhiah , Cahyono Murti Siti Tamaroh , Kanetro Bayu
Published: October 2024

Cendol merupakan makanan khas Indonesia yang pada umumnya berbahan baku dari tepung beras. Pati garut mempunyai karakteristik yang menyerupai tepung tapioka dan berantioksidan. Bunga telang mengandung komponen antosianin yang bersifat antioksidan. Penelitian ini bertujuan untuk menghasilkan cendol tepung beras-pati garut dengan penambahan bunga telang yang disukai panelis dan memiliki antioksidan. Pada penelitian menggunakan Rancangan Acak Lengkap (RAL) dengan 2 faktor yaitu tepung beras:pati garut (80:20, 70:30, dan 60:40) dan penambahan ekstrak bunga telang (5,10 dan 15 ml). Cendol yang dihasilkan diuji kemudia dianalisis fisik dan kimia. Data yang diperoleh dilakukan uji statistic One Way Anova dan jika terdapat beda nyata dilakukan uji DNMRT pada tingkat kepercayaan 95%. Penelitian ini menunjukkan bahwa substitusi tepung beras-pati garut berpengaruh nyata terhadap. Hasil penelitian terbaik adalah cendol dengan substitusi tepung beras-tepung garut 60:40 dan penambahan ekstrak bunga telang 15%, dengan aktivitas antioksidan 10,06% RSA, kadar fenol total 20,63 mg EAG/g bk, warna L* 30,03, a* 4,64 dan b* -11,64, kesukaan terhadap warna (3,96), aroma (4,00), tekstur (3,84), rasa (3,76) dan keseluruhan 3,96.
Characteristics of risk factors and molecular genetic parameters in children with chronic kidney disease
Authors: Sedashkina O. A. , Kolsanov A. V. , Karas S. I.
Published: October 2024

Introduction. Information about the health status of children with nephrological pathology includes many manifestations of functional system disorders. However, early diagnosis of chronic kidney disease (CKD) is rarely carried out due to the lack of reliable predictors of this process.

The aim: To analyze the association of anamnestic signs, laboratory and genetic research results with chronic kidney disease in children to identify potential predictors of the disease.

Material and Methods. The data were obtained from a single-center retrospective catamnestic cohort study (2011–2022). The main group included 128 children with chronic kidney disease aged 1 to 17 years. The comparison group consisted of 30 children without diagnosed kidney pathology aged from 1 to 17 years. There were no statistically significant differences in sex and age between the two groups. The informative value of more than 150 features, including anamnestic ones, the state of the mother’s health during pregnancy, antenatal and perinatal factors, features of the child’s development and manifestation of the disease, the results of clinical, laboratory, and genetic research methods were evaluated. An integrated approach to the study included methods for hypotheses testing on statistical significance of indicators differences, regression analysis, and ROC analysis.

Results. Hereditary burden of nephrological pathology in the family, unfavorable course of pregnancy (anemia, toxicosis of the first half), obstetric and somatic pathology in the mother, the serial number of childbirth are associated with the subsequent development of CKD. Erythrocytes in the urine and daily protein loss were detected only in the group of children with CKD. In this group, a decrease in the number of red blood cells, increased erythrocyte sedimentation rate (ESR), allergies at an early age, otitis media, persistent viral and bacterial infections, and a number of signs of connective tissue dysplasia were more common. The main group statistically significantly differed from the comparison group by a number of polymorphic genetic markers. It can be assumed that the polymorphisms AGT1 Thr174Thr, AGT2 Thr235Thr, NO3 C786T are associated with a predisposition to CKD, and the products of polymorphisms AGT1 Thr174Met, AGT2 Met235Met, R1 AGT2 C1166C, NO3 T786T may have a protective effect according to development of CKD.

Conclusion. The risk factors for CKD identified in this study can be used to develop software to support medical decision making for early detection of children at high risk of disease progression.
The relationship between iron metabolism markers and parameters of carbohydrate and lipid metabolism in patients with overweight and obesity
Authors: Musina N. N. , Slavkina Ya. S. , Petrukhina D. A. , Zima A. P. , Prokhorenko T. S. , Zavadovskaya V. D. , Saprina T. V.
Published: October 2024

Background: Hyperferritinemia associated with obesity and insulin resistance is a link between the components of the metabolic syndrome and a possible triggering factor in the pathogenesis of carbohydrate metabolism disorders and dyslipidemia.

Aim: To establish possible relationships between ferrokinetic parameters, parameters of lipid and carbohydrate metabolism in overweight and obese patients, and to analyze the possibility of using iron metabolism parameters (ferritin and serum iron) as predictors of carbohydrate metabolism disorders in this cohort of patients.

Material and Methods. The study included 52 overweight or obese patients. In the course of the study, patients were stratified into groups depending on the presence of carbohydrate metabolism disorders (CMD), and depending on the state of iron metabolism. Among all patients included in the study, an assessment of anthropometric data, a study of glycated hemoglobin, a standard glucose tolerance test with 75 g of glucose, a study of hematological parameters, as well as biochemical parameters of iron metabolism – the concentration of serum iron, transferrin and ferritin, was carried out.

Results. Patients with CMD – impaired glucose tolerance or impaired fasting glycaemia – had significantly higher serum ferritin levels than obese patients without CMD (p = 0.019). In persons with a high level of ferritin, CMD developed significantly more often than in patients with a ferritin content in the range below the 75th percentile (χ2 = 5.278, p = 0.022). According to the ROC analysis, ferritin showed a rather high sensitivity – 75%, and specificity – 84.4% at a diagnostic threshold of 126.65 ng/ml (area under the curve = 0.738; p = 0.016) in the diagnosis of prediabetes (IGT/IFG) in overweight and obese individuals.

Conclusion. High concentrations of iron and ferritin are positively associated with CMD, with ferritin being a promising predictor of prediabetes and type 2 diabetes mellitus.
Antifungal activity’s study of the of new derivatives of pyrrolo[3,4-c]pyrazol-3-ones and pyrazol-3- carboxamides in the biofilm model of Candida spp.
Authors: Novikova V. V. , Bobrovskaya O. V. , Gein V. L.
Published: October 2024

The search for new antifungal drugs is current interest due to the wide spread of fungal infections. To simulate the antifungal effect of new promising compounds with high antifungal activity in planktonic culture in clinical practice, it is necessary to study their effect on the biofilm of micromycetes.

Aim: To study the antifungal activity of new promising representatives of silver salts of pyrazoles and their condensed systems under conditions of biofilm formation.

Material and Methods. To study the antifungal activity of silver salts I and II, the micromethod of two-fold serial dilutions was used. Activity against a typical and 14 clinical highly virulent isolates of C. albicans was studied. The study of the antimycotic activity of substances under biofilm conditions was carried out using resazurin to quantify the degree of biofilm formation. The minimum inhibitory concentrations for biofilms were calculated (sMIC50 - the concentration of the antifungal substance at which a 50% decrease in fluorescence is observed compared to the positive control).

Results and Discussion. It was shown that the antifungal effect of the studied compounds in biofilm culture of clinical strains of Candida spp. is significantly lower than in planktonic culture. High antifungal activity of the silver salt of pyrazole-3- carboxamide in planktonic and biofilm cultures of resistant strains of Candida albicans, exceeding the effect of the reference drug fluconazole by 2.8–11.2 times, was revealed.

Conclusion. A promising pyrazole-3-carboxamide derivative has been identified that effectively inhibits the growth of Candida albicans biofilms, which can be recommended for further study.
Changes in electrical parameters of the heart in an experimental model of malignant tumor growth during of hyperthyroidism
Authors: Frantsiyants E. M. , Kaplieva I. V. , Sheiko E. A. , Surikova E. I. , Vasileva E. O. , Neskubina I. V. , Gusareva M. A. , Bykadorova O. V. , Trepitaki L. K. , Cheryarina N. D. , Serdyukova E. V. , Vereskunova A. A.
Published: October 2024

Experimental and clinical studies demonstrate the possibility of modulating the development of malignant tumors in thyroid imbalance, in particular hyperthyroidism, which negatively affects the electrophysiology of the heart. In an experimental model of tumor growth during of hyperthyroidism, activation of the tumor was shown.

Aim: To study electrophysiological parameters of the mouse heart at the initial stages of transplantable tumor growth during of hyperthyroidism.

Material and Methods. In female mice of the C57BL/6 line (n = 20) was created a model of melanoma B16/F10 growth during of hyperthyroidism, which was induced by daily intraperitoneal administration of liothyronine sodium (T3) for a long time and confirmed by determining the content of thyroid-stimulating hormone and triiodothyronine in the blood using the radioimmune method. On the 5th day of T3 administration, the melanoma was transplanted. ECG was recorded non-invasively (ecgTUN- NEL, ecgAVG software, emka TECHNOLOGIES, France) on the 1st and 3rd days of T3 administration, in groups with a tumor – on the 6th day after its transplantation.

Results. Pathological changes were revealed: in the group with hyperthyroidism – rhythm irregularity, decrease the amplitude of P and T below the isoline, widening of the QRS, on the 3rd day – the death of 1 mouse was noted due to large-focal myocardial infarction; in the group with melanoma – only sinus arrhythmia and decreased heart rate; in the group with a combination of pathologies – an almost normal ECG, with the exception of an increase in P amplitude and a slight increase in QRS.

Conclusion. Already in the early stages of hyperthyroidism or tumor growth, there was a violation of myocardial depolarization/ repolarization processes, capable of causing even death of the animal. In case of comorbidity, the majority of ECG parameters normalized, indicating the inclusion of compensatory mechanisms in the interaction of pathologies. The results demonstrate the need for a deeper study of the mechanisms of interaction of several simultaneously existing pathologies in the body.
Comparative analysis of the structure of the heart and blood vessels surgeries, taking into account the clinical and functional status of patients with coronary heart disease in 2015 and 2020
Authors: Efros L. A. , Lukin O. P. , Belogorokhov V. S. , Ushakov A. Yu.
Published: October 2024

Relevance. In a very short period of time, surgical treatment methods have become widespread due to the expansion of indicators for performing heart surgery in patients with severe complicated forms of coronary heart disease and the use of combined surgical operations.

Aim: To study changes in the clinical and functional status of patients depending on the type of surgical intervention for coronary artery disease in different time periods in the gender aspect.

Material and Methods. The study was conducted retrospectively. For comparative analysis, patients with an established diagnosis of coronary heart disease who underwent surgical treatment at the Federal Center for Cardiovascular Surgery of the of the Ministry of Healthcare of the Russian Federation (Chelyabinsk) in 2015 (n = 1017) and 2020 (n = 967) were included. Of the total number of patients in 2015, there were 771 (75.8%) men and 246 (24.2%) women, in 2020 718 (74.3%) and 249

(25.7%), respectively.

Results. In the structure of interventions performed, there is a decrease in the number of almost all types of surgical interventions for complications of myocardial infarction, most pronounced in relation to resection of the left ventricular aneurysm, reconstruction of the left ventricle and operations in combination with mitral valve replacement. In a large percentage of cases, patients with a history of risk factors for cardiovascular diseases are referred for coronary artery bypass surgery, regardless of gender. The majority of patients had angina pectoris of the 3rd–4th functional class. However, there is a trend towards a decrease in the proportion of people with post-infarction cardiosclerosis when referred for surgery.

Conclusion. Despite the significant volume and availability of practical information, the number of patients with major cardiovascular risk factors is not decreasing.
Improving the organization of medical care for patients in the specialty of medical rehabilitation in the Tomsk oblast
Authors: Kudelina O. V. , Tsaizer D. V.
Published: October 2024

More than a third of the total population of the planet needs medical rehabilitation and the need will increase in the future. The prospective increase in life expectancy by the middle of the 21st century will be accompanied by an increase in the share of malignant neoplasms and diseases of the circulatory system in the morbidity structure, and the level of injuries will remain unchanged. These factors will negatively affect a person’s functional capabilities and will contribute to an increase in disability, increasing the relevance of medical rehabilitation. In Russia, according to the current procedure, there is a three-stage organization of medical rehabilitation. The implementation of these stages is carried out within the regional territorial programs of state guarantees (TPSG) of free medical care to citizens, which limits the financial accessibility of the completed cycle of medical rehabilitation for patients, due to budgetary allocations and the compulsory health insurance program, negatively affecting the quality of care provided. The article assesses the volume of medical rehabilitation provided in inpatient settings in the TPSG of the Tomsk oblast for the period of 2019–2022. Currently, three medical organizations in the region of different forms of ownership provide medical rehabilitation. In total, over a four-year-period, 8,804 cases in the specialty of medical rehabilitation were completed in the amount of 378.9 million rubles. An underfulfillment of the volume and costs of medical care during medical rehabilitation approved by the TPSG was recognized, as well as an outflow of patients for treatment to other regions (1,864 people during the study period). The most popular clinical and statistical groups (CSG) for which residents of the Tomsk oblast need rehabilitation measures have been identified, and organizational ways to improve the profile of this medical care have been substantiated.
Numerical model of the aortic valve prosthetic frame
Authors: Klyshnikov K. Yu. , Ovcharenko E. A. , Onishchenko P. S. , Glushkova T. V. , Akentyeva T. N. , Kostyunin A. E. , Rezvova M. A. , Barbarash O. L.
Published: October 2024

Aim: To perform a quantitative analysis of the effectiveness of three concepts of heart valve prosthesis support frames from the perspective of their safety under the most critical loads, conducted through numerical modeling.

Materials and Methods. The study utilized three computer-generated concepts of stent-like support frames, created based on the analysis of similar balloon-expandable prostheses. The modeling was conducted using Abaqus/CAE software and included the analysis of two key loads characteristic for this element: compression and implantation phases. A linear description of cobalt-chromium was used as the material model. The feasibility of the concepts was quantitatively assessed using von Mises stress and its qualitative distribution on the surface of the models as stress contours.

Results. The analysis revealed that two of the three proposed models experienced stresses exceeding the strength limit (933 MPa) – 999.6 and 954.0 MPa during the compression phase and reaching 1022.4 and 1044.7 MPa, respectively, during the implantation phase. Concept 3 had significantly lower stresses during loading; however, in the working state, the indicators approached the threshold, reaching 924.2 MPa.

Conclusion. Numerical modeling identified the inefficacy of concepts 1 and 2 and directions for optimizing concept 3 – reducing amplitudes to form a “strength reserve” for stress. The analysis emphasized the importance of numerical modeling in the early assessment and optimization of medical devices.
Angiotensin 1-7 – a peptide that increases the resistance of the heart to ischemia and reperfusion: narrative review
Authors: Mukhomedzyanov A. V. , Popov S. V. , Maslov L. N. , Naryzhnaya N. V. , Sirotina M. A. , Kurbatov B. K. , Gorbunov A. S. , Kilin M. , Kan A. , Krylatov A. V. , Podoksenov Yu. K. , Stepanov I. V.
Published: October 2024

Background. The high mortality rate among patients with acute myocardial infarction (AMI) is an important problem of modern cardiology. In recent years, there has not been a significant decrease in mortality in AMI. Drugs used to treat AMI are not effective enough, so there is a need to develop fundamentally new drugs that can significantly increase the heart’s tolerance to ischemia/reperfusion (I/R). Angiotensin 1-7 peptide, which can increase cardiac tolerance to I/R by activating Mas receptor in myocardial tissue, could become a prototype of such drugs. The following enzymes are involved in the formation of the cardioprotective effect of angiotensin 1-7: NO-synthase, soluble guanylyl cyclase, phosphoinositide 3-kinase, extracellular signal-regulated kinases-1/2, Akt kinase and, possibly, protein kinase G. Indirect data indicate that the hypothetical end effector in the cardioprotective impact of angiotensin 1-7 could be mitochondrial or sarcolemmal ATP-sensitive K+ channel.

Aim: To review 1-7 role in increasing the heart resistance to ischemia and reperfusion. The literature search was carried out in the PubMed database with queries “angiotensin 1-7 receptors”, “stress”, “angiotensin 1-7”, “mas receptor”, “cardioprotective effects of angiotensin 1-7”.
Mechanical dyssynchrony in patients with chronic heart failure and left bundle branch block
Authors: Mamedova A. I. , Prihod’ko N. A. , Lubimceva T. A. , Kozlenok A. V. , Lebedev D. S.
Published: October 2024

Background. The main problem in patient selection for cardiac resynchronization therapy (CRT) is the lack of unified approaches to the definition of mechanical dyssynchrony (MD) and selection criteria, particularly, in patients with left bundle branch block (LBBB).

Aim: To study mechanical dyssynchrony indices and three-dimensional Echo (3DE) criteria of global and local contractility function in patients with chronic heart failure (CHF) and LBBB during different types of isolated left ventricle (LV) pacing.

Methodology and Research Methods. The experimental intraoperative study involved 88 points obtained from 12 patients with CRT class IA indications and LBBB. During isolated LV pacing as part of CRT implantation procedure endocardial and epicardial pacing were obtained. Transesophageal Echo (TEE) cineloops recording and paced QRS complex morphology registrations by means of LabSystem Pro Electrophysiological Recording System (Bard Electrophysiology, USA) were performed during each stimulation episode. Philips Qlab 10 software was used for TEE data analysis.

Results. The global (3D EF, 23.8 [22; 28.4], GLS, –5.33% [10.90%; –15.4%]) and local contractility (ExсAvg 3.5 [2.1; 5.6]) criteria and dyssyncrony indices (SDI-16, 14.9 [8.9; 23.1]) showed severe systolic dysfunction and intraventricular dyssynchrony – typical signs in this patient group, and differed significantly (3D EF, p = 0.003; GLS, p = 0.004; ExcAvg, p < 0.001; Tmsv-6 SD, р = 0.03) depending on the stimulation method and site. A moderate direct correlation between SDI-16 and the QRS duration (common electical dyssynchrony criterium) and inverse correlation with ExcAvg and 3D LVEF also describes LV response.
Representation of Human Resources in The Accounting System: Methods and Applications
Authors: Binici Fatih Ömür
Published: October 2024

The rapid development and progress of the knowledge-based economy has increased the importance of human resources as a key factor in determining the overall value of companies. However, traditional accounting methods have difficulty in accurately reflecting the true value of such intangible assets. In this context, the study aims to examine how human capital, which is becoming increasingly important for companies, can be represented in accounting systems and the limitations of current accounting standards. The study discusses controversial issues and problems related to human capital accounting practices and presents sample applications. It concludes that, under TPL/GCIAS and standards, expenditure on human resources by enterprises should be expensed in the period in which it is incurred, rather than capitalized, because human resources are not considered intangible assets.
DAMPAK DANA TRANSFER DAN FLYPAPER EFFECT PENDAPATAN ASLI DAERAH PADA BELANJA MODAL DI KABUPATEN/KOTA SE-SULAWESI TENGAH
Authors: Sania Nuzul , Yamin Nina Yusnita , Paranoan Selmita , Tanra Andi Ainil Mufidah
Published: October 2024

Desentralisasi fiskal di Indonesia bertujuan untuk memanjukkan kesejahteraan masyarakat melalui belanja daerah termasuk belanja modal. Namun realitanya, dana transfer dari pemerintah pusat masih menjadi sumber utama oleh daerah. Penelitian ini mengkaji pengaruh Pendapatan Asli Daerah (PAD), Dana Alokasi Umum (DAU), dan Dana Alokasi Khusus (DAK) terhadap belanja modal di Kabupaten/Kota se-Sulawesi Tengah selama periode tahun 2018 – 2022. Penelitian ini menggunakan metode sensus dengan 65 sampel, yakni keseluruhan  Kabupaten/Kota di Sulawesi Tengah. Data sekunder yakni Laporan Realisasi Anggaran APBD di peroleh melalui BPK perwakilan Sulawesi Tengah. Teknik analisis data memakai regresi linier berganda. Hasil penelitian memperlihatkan bahwa PAD dan DAK berpengaruh positif dan signifikan terhadap Belanja Modal. Artinya, bahwa peningkatan PAD dan DAK, semakin tinggi pula Belanja Modal. Namun, DAU tidak memberikan pengaruh secara signifikan. Hal ini memperlihatkan adanya fenomena Flypaper effect, di mana peningkatan DAU tidak mendorong peningkatan belanja modal secara proporsional. Penelitian ini berimplikasi pada upaya memaksimalkan sumber-sumber pendapatan daerah dan pemenuhan belanja modal menjadi penting untuk mencapai kemandirian keuangan, tanpa ketergantungan pada dana transfer dari pemerintah pusat.
PENGARUH PEMAHAMAN REGULASI, KOMITMEN ORGANISASI, DAN KUALITAS SDM TERHADAP KINERJA PENGELOLAAN KEUANGAN KELURAHAN
Authors: Carlin Tanesya , Suhaedi Wirawan , Rakhmawati Intan
Published: October 2024

Studi yang dilaksanakan menguji pengaruh dari pemahaman regulasi, komitmen organisasi, dan kualitas SDM pada performa kerja dalam mengelola keuangan kelurahan. Studi dilakukan di 50 kelurahan yang tersebar di 6 kecamatan berbeda yang ada di Kota Mataram. Studi yang dilaksanakan mempergunakan pendekatan kuantitatif dengan metode penyebaran kuesioner kepada aparatur pengelola keuangan kelurahan. Temuan studi mengindikasikan jika pemahaman regulasi, komitmen organisasi, dan kualitas SDM pada kinerja dalam mengelola keuangan kelurahan tidak berdampak nyata pada kinerja pengelolaan keuangan kelurahan. Temuan tersebut mengindikasikan bahwa ketiga faktor yang diteliti bukanlah faktor utama yang menentukan kinerja dalam mengelola keuangan kelurahan. Implikasi dari penelitian ini adalah pihak kelurahan diharapkan mencari faktor-faktor lain yang mungkin memiliki pengaruh yang lebih signifikan, seperti pengawasan, pemberian insentif kinerja, dan faktor lainnya.
Socialization of Education on the Importance of Balanced Nutrition for the Young Generation in the Millennial Farmers Group of Kabul Village
Authors: Putri Nydia Alisa , Ilmiati Nur , Lestari Dewi Putri , Sarjan Achmad Fajar Natotama , Sarjan Muhammad
Published: October 2024

The millennial generation, a growing segment of Indonesia's youth, is expected to play a crucial role in the nation's future development. Thus, it is imperative to adequately prepare this resource, particularly by enhancing the quality of their education and health. Knowledge and understanding of health, especially nutrition, are critical for this group as it directly impacts their cognitive abilities. However, many young people still lack awareness of balanced nutrition, leading to various health. To address this, an educational outreach on the importance of balanced nutrition was conducted for the millennial farmer group in Kabul Village. The goal was to equip the youth with knowledge about balanced nutrition, influencing their eating habits and dietary patterns in the target village. The outreach employed educational methods, including material presentations by the team, interactive discussions, and summarizing the discussion outcomes. Monitoring results during the outreach indicated high participant interest, evidenced by numerous questions, particularly regarding parental roles in ensuring balanced nutrition for adolescent family members. Young participants highlighted the challenge of avoiding unhealthy snacks due to the proliferation of culinary trends and social media influences, often leading them to try foods without considering their nutritional value. The balanced nutrition education initiative aims to benefit both millennials and the older generation. Consequently, it is hoped that parents will emphasize balanced nutrition messages to their children within their families.
O PODCAST COMO FERRAMENTA DE INTEGRAÇÃO E RESGATE DA ORALIDADE PARA OS ALUNOS DO PROGRAMA DE ENVELHECIMENTO DA APAE BELÉM
Authors: Neves Waldecir Jorge dos Santos , Villaça Albéria Xavier de Souza
Published: October 2024

Este artigo trata sobre o uso do podcast como ferramenta pedagógica de integração e
resgate da oralidade para alunos do Programa de Envelhecimento da APAE Belém. Ele surgiu
como estratégia para manter os atendimentos de forma on-line pelo uso das Tecnologias da
Informação e Comunicação em tempos de pandemia. Considerado como uma ferramenta de
compartilhamento de áudio, é um gênero textual do tipo discursivo oral e tem sido cada vez
mais usado com finalidades pedagógicas. O uso do podcast ganhou destaque a partir construção
do Projeto “Papo Firme Podcast”, que objetiva aproximar os alunos pelo uso de recursos tecnológicos, visando a integração, o resgate dos laços de amizade, da oralidade e afeto, mantido
entre os alunos que fazem parte do Programa de Envelhecimento da APAE Belém. Utilizou-se
o relato de experiência como metodologia e a sua aplicabilidade impactou positivamente na
oralidade, na saúde mental, na qualidade de vida, na autonomia e na inclusão social e digital da
pessoa com Deficiência Intelectual e Múltipla.
A RELAÇÃO ENTRE A INCLUSÃO DAS PESSOAS COM DEFICIÊNCIA PELO ESPORTE E A ATUAÇÃO DO SERVIÇO SOCIAL NA ASSOCIAÇÃO DE PAIS E AMIGOS DOS EXCEPCIONAIS (APAE) DE ARAPIRACA (AL)
Authors: Messias Thalita da Silva , Lopes Flávia Augusta Santos de Melo , Lima Viviane Mello
Published: October 2024

O presente artigo é resultante do processo formativo de Estágio Obrigatório Supervisionado em Serviço Social realizado na Associação de Pais e Amigos dos Excepcionas (APAE)
de Arapiraca/Alagoas. O objetivo é abordar a relação entre a inclusão das pessoas com deficiência pelo esporte, a partir do projeto “APAExonados pelo ASA” (Agremiação Sportiva
Arapiraquense), desenvolvido pelo setor de Serviço Social da instituição, demonstrando, dessa
forma, a potencialidade da atuação desses(as) profissionais em instituições de Terceiro Setor.
A primeira seção aborda a importância do acesso aos direitos sociais, o que inclui o acesso ao
esporte, como possibilidade de enfrentamento à luta anticapacitista. Já a segunda seção trata
sobre a atuação do Serviço Social na APAE de Arapiraca frente à necessidade de inclusão das
pessoas com deficiência numa sociedade que impõe diversas barreiras. A partir disso, o Projeto
“APAExonados pelo ASA” será apresentado como uma proposta de parceria para envolvimento dos(as) usuários(as) da instituição para além dos muros apaeanos com ações educativas, de
esporte e lazer. O artigo foi construído criticamente com embasamento teórico e legal a partir
de pesquisa bibliográfica e documental, que demonstram a relevância social de tais reflexões,
já que essas contribuem para a concretização da missão institucional de promover e articular
ações de defesa de direitos, prevenção, orientações, prestação de serviços, apoio à família, direcionadas à melhoria da qualidade de vida da pessoa com deficiência e à construção de uma
sociedade justa e solidária
A PSICOMOTRICIDADE COMO ESTRATÉGIA PEDAGÓGICA NO ATENDIMENTO EDUCACIONAL ESPECIALIZADO DA APAE DE PAPANDUVA-SC
Authors: Silva Jefferson Moisés Santos da
Published: October 2024

Este artigo oferece uma reflexão sobre os desafios e conquistas da utilização da psicomotricidade como estratégia pedagógica na educação especial da APAE – Papanduva/SC. A
base epistemológica diz respeito ao método (auto)biográfico em diálogo com o materialismo
dialético, cuja práxis está centrada na neutralização do protagonismo do professor. Esta estratégia, previamente aprovada no planejamento pedagógico, teve em conta o desinteresse e a falta
de iniciativa dos alunos. Também se considerou a necessidade de desenvolver um sentido de autonomia nas crianças, especialmente por terem deficiências. A partir daí, cada criança construiu
a sua identidade, autonomia e protagonismo explorando espaços com outros membros da instituição e os seus pares. O objetivo desta proposta pedagógica foi desenvolver a aprendizagem
pela movimentação corporal das crianças, pela brincadeira, numa mediação lúdica realizada
pelo professor do AEE.
NOVAS TECNOLOGIAS E FLEXIBILIDADE CURRICULAR NA FORMAÇÃO DE PROFESSORES DE BIOLOGIA: Uma Abordagem a partir da EaD
Authors: Reis Liliane Belz dos
Published: October 2024

Este estudo tem como meta fazer uma análise da função das tecnologias no desenvolvimento e melhoria do ensino a distância (EaD) para a disciplina de Biologia. As Tecnologias de Informação e Comunicação (TIC) na educação à distância somou ao longo dos anos para alicerçar seu desenvolvimento, pois foi uma peça preponderante para a formação de pessoal tornando-os habilitados, proporcionando-lhes alternativas inovadoras, contribuindo grandemente com o desenvolvimento da ciência e tecnologia assim como de toda a comunidade, dando oportunidades e garantias aos estudantes afim de que eles tenham a seu dispor uma formação apropriada na profissão de sua escolha, sendo primordial para as instituições de ensino. Esclarecendo este aparte, no presente estudo optou-se por aprofundar o conhecimento a respeito do Projeto Político Pedagógico (PPP) que direciona o Curso de Licenciatura em Biologia (modalidade à distância), e sua contribuição para a aprendizagem e formação do aluno, vencendo as grandes divisões que sofreu os currículos de Biologia, e assim acabara comprometendo a habilitação do professor para trabalhar na educação básica. Esta pesquisa trouxe um estudo qualitativo, descritivo e bibliográfico. O resultado do estudo apontou que o desenvolvimento das aulas de Biologia por meio da educação à distância contribui para elevar a qualidade do ensino, pois fornece uma ferramenta de aprendizagem que pode ser aplicada pelo professor no âmbito do construtivismo trazendo igualdade de oportunidade; por meio do uso de novas tecnologias em relação custo x benefício; qualidade; educação permanente e flexibilidade curricular.

Palavras-chave: EaD. Biologia. Projeto Político Pedagógico. Tecnologias.