bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of the Accuracy of Two Different Dynamic Navigation System Registration Methods for Dental Implant Placement in the Posterior Area: An In Vitro Study
Authors: Wei Tai , Ma Feifei , Sun Feng , Ma Yu
Published: January 2023

Purpose: To compare the U-tube and cusp dynamic navigation system registration methods in the use of dental implant placement, and to assess the influence of the location of missing teeth on these registrations. Methods: 32 resin mandible models and 64 implants were utilized, with implants being placed using one of the two registration methods selected at random. Accuracy was measured through the superimposition of the final and planned implant positions. Angular deviation, 3D entry deviation, and 3D apex deviation were analyzed. Results: The overall mean 3D deviation was 1.089 ± 0.515 mm at the entry point and 1.174 ± 0.531 mm at the apex point, and mean angular deviation was 1.970 ± 1.042 degrees. No significant difference (p > 0.05) was observed when comparing these two registration methods. However, the U-tube method showed significant difference when assessing the location of missing teeth (without distal-extension absence and distal-extension absence), whereas cusp registration was unaffected. Conclusions: Both the U-tube and cusp dynamic navigation system registration methods are accurate when implemented in vitro. Besides, the cusp registration technique can also overcome several of the limitations of the U-tube approach and the accuracy of it was not influenced by the location of the missing teeth, highlighting it as a method worthy of further clinical research.
A Long Road to Personalized Medicine in Heart Failure and Cardiomyopathies
Authors: Nagatomo Yuji
Published: January 2023

Over the past few decades, a drastic increase in the prevalence of heart failure (HF) has been observed worldwide, and is now often referred to as the “Heart failure pandemic” [...]
How Diversity and Accessibility Affect Street Vitality in Historic Districts?
Authors: Huang Jing , Hu Xiao , Wang Jieqiong , Lu Andong
Published: January 2023

The loss of traditional features and place memory, and ultimately vibrancy in historic districts, has attracted substantial attention in today’s urban design. Most conventional theories are of the consensus that diversity and accessibility characteristics play important roles in creating street vitality, whereas how these characteristics influence street vitality in historic districts has not been thoroughly explored. Furthermore, it is less clear as to which characteristics exert greater influence. Taking the Drum Tower Muslim District, a historical neighborhood in Xi’an, China, as a case study, this paper employs geospatial data to examine how diversity and accessibility influence street vitality. This study identifies seven factors of diversity and accessibility, and incorporates them into a spatial multivariate regression model for analysis. The results indicate that accessibility makes a stronger impact on the street vitality than diversity does. Furthermore, the closeness of streets, the functional density, the intersection density, the location of public transportation and the density of public infrastructure are the top five factors influencing street vitality. The outcome of this study will shed light on what constitutes a vibrant historic district and will help to inform us as to where and how we can improve street vitality.
Free Radicals Mediated Redox Signaling in Plant Stress Tolerance
Authors: Rai Krishna Kumar , Kaushik Prashant
Published: January 2023

Abiotic and biotic stresses negatively affect plant cellular and biological processes, limiting their growth and productivity. Plants respond to these environmental cues and biotrophic attackers by activating intricate metabolic-molecular signaling networks precisely and coordinately. One of the initial signaling networks activated is involved in the generation of reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive sulfur species (RSS). Recent research has exemplified that ROS below the threshold level can stimulate plant survival by modulating redox homeostasis and regulating various genes of the stress defense pathway. In contrast, RNS regulates the stress tolerance potential of crop plants by modulating post-translation modification processes, such as S-nitrosation and tyrosine nitration, improving the stability of protein and DNA and activating the expression of downstream stress-responsive genes. RSS has recently emerged as a new warrior in combating plant stress-induced oxidative damage by modulating various physiological and stress-related processes. Several recent findings have corroborated the existence of intertwined signaling of ROS/RNS/RSS, playing a substantial role in crop stress management. However, the molecular mechanisms underlying their remarkable effect are still unknown. This review comprehensively describes recent ROS/RNS/RSS biology advancements and how they can modulate cell signaling and gene regulation for abiotic stress management in crop plants. Further, the review summarizes the latest information on how these ROS/RNS/RSS signaling interacts with other plant growth regulators and modulates essential plant functions, particularly photosynthesis, cell growth, and apoptosis.
Vitamin B1 Deficiency and Perimyocarditis Fulminans: A Case Study of Shoshin Syndrome in a Woman Following an Unbalanced Dietary Pattern Followed by a Literature Review
Authors: Rohun Justyna , Dorniak Karolina , Młodziński Krzysztof , Bachorski Witold , Gruchała Marcin , Raczak Grzegorz , Daniłowicz-Szymanowicz Ludmiła
Published: January 2023

(1) Background: vitamin B1 level depletion, known as a beriberi syndrome, can lead to severe cardiovascular complications, from which perimyocarditis fulminans is one of the most severe. (2) Methods: this is a retrospective case study that includes an adult patient with clinical presentations of acute heart failure (HF) symptoms following perimyocarditis on the grounds of thiamine deficiency. (3) Results: A 49-year-old woman presented with acute HF symptoms due to perimyocarditis. The patient suddenly developed refractory cardiogenic shock with metabolic acidosis requiring maximal medical management, including an intra-aortic balloon pump and extracorporeal membrane oxygenation. Due to additional peripheral polyneuropathy, beriberi disease was suspected after excluding other possible causes of the patient’s condition. After administration of vitamin B1, clinical improvement in the patient’s condition and the resolution of metabolic abnormalities were observed, which ultimately confirmed the diagnosis of Shoshin syndrome caused by the implementation of a gluten-free diet without indications for its adherence. (4) Conclusions: Fulminant beriberi disease, although considered rare, is a life-threatening condition and should always be included in the differential diagnosis of critically ill patients, notably those with malnutrition. An unbalanced diet can be detrimental and have severe consequences, i.e., perimyocarditis fulminans. However, treatment with thiamine can significantly improve the patient’s cardiac function and restore hemodynamic and metabolic parameters.
Pulmonary Fibrosis and Progressive Pulmonary Fibrosis in a Prospective Registry of Interstitial Lung Diseases in Eastern Siberia
Authors: Nashatyreva Maria S. , Trofimenko Irina N. , Chernyak Boris A. , Avdeev Sergey N.
Published: January 2023

Interstitial lung diseases (ILD) are part of a large heterogeneous group of diseases that differ in many ways (in their cause, clinical presentation, and response to therapy, etc.), but there are similar pathophysiological mechanisms involved in the development of the inflammation and/or fibrosis of the lungs. Currently, several criteria for pulmonary fibrosis (PF) and progressive pulmonary fibrosis (PPF) are proposed, and the information on the prevalence and characteristics of these conditions is limited. The aim of this study was to evaluate the spectrum of PF and PPF according to the registry of patients with ILD in eastern Siberia. Materials and methods: The study included patients with ILD from all of the medical institutions in the Irkutsk region (eastern Siberia). Each case of ILD (n = 270) was reviewed by a multidisciplinary discussion panel. The ILD patient registry included information on the clinical findings, history, pulmonary function tests, high-resolution computed tomography (HRCT), and histological findings. The follow-up period for the patients varied from 1 to 5 years. Results: Pulmonary fibrosis was detected by HRCT in 104 patients with ILD (38.5%). PF was present in 100% of the patients with IPF and SS-ILD, in 90.9% of the patients with CHP, in 71.4% of the patients with NSIP, and in 60% of the patients with RA-ILD. Sixty-two patients met the criteria for PPF (23.0% of the entire ILD cohort and 59.6% of the patients with PF). PPF occurred most often in the patients with IPF, CHP, IPAF, and SSc-ILD: 100%, 72.7%, 40%, and 38.5% of them, respectively. The variables associated with fibrosis progression included Velcro crackles (OR 18.3, p < 0.001) and late diagnosis (OR 4.1, p < 0.001). Conclusion: Pulmonary fibrosis and progressive pulmonary fibrosis are common in patients with ILD. The high mortality rate of PPF dictates the need for the active, early detection of a progressive fibrosing course of a wide range of ILD and suggests that further studies assessing the effectiveness of the interventions might be warranted.
5,8-Di-tert-butyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione—A New Lipophilic N-oxyl Radical Precursor
Authors: Lopat’eva Elena R. , Kutykov Artem D. , Krylov Igor B. , Terent’ev Alexander O.
Published: January 2023

N-hydroxyimides are widely known as organocatalysts for aerobic oxidation and oxidative coupling reactions, in which corresponding imide-N-oxyl radicals play the role of catalytically active hydrogen atom abstracting species. The drawbacks of many N-hydroxyimides are poor solubility in low polarity solvents and limited activity in the cleavage of unactivated C–H bonds. To overcome these shortcomings, we have synthesized a new lipophilic N-hydroxyimide, 5,8-di-tert-butyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione, with high solubility in low-polarity solvents such as DCM. According to the EPR study, the stability of the corresponding imide-N-oxyl radical is comparable to that of the non-tert-butylated analogue, naphthalimide-N-oxyl radical. DFT calculations showed that the NO–H bond dissociation enthalpy (BDE) in the synthesized tert-butylated-N-hydroxynaphthalimide is one of the highest in N-hydroxyimide series, which corresponds to high hydrogen atom abstracting reactivity and may be useful in catalysis of strong C–H bond oxidative cleavage. The synthesized compound can be considered as catalyst for liquid-phase free-radical oxidation and oxidative coupling reactions in non-polar media where solubility was previously the limiting factor.
Understanding the Corrosion Behavior of Nickel–Aluminum Bronze Induced by Cavitation Corrosion Using Electrochemical Noise: Selective Phase Corrosion and Uniform Corrosion
Authors: Li Liang , Qiao Yanxin , Zhang Lianmin , Ma Aili , Ma Rongyao , Zheng Yugui
Published: January 2023

Nickel–aluminum bronze (NAB) is widely used to fabricate flow-handling components because of its good cavitation corrosion (CE) resistance and superior casting property. The existence of different phases, e.g., the α phase, β phase and κ phase, can cause significant selective phase corrosion on NAB. However, under the action of CE with different times, the influence of these phases on the corrosion behavior of NAB, including selective phase corrosion and uniform corrosion, needs to be further studied, which can contribute to a deep understanding of the CE mechanism of NAB in corrosive media. In this work, the corrosion behavior of NAB in 3.5 wt.% NaCl solution after different CE times was evaluated by electrochemical noise (EN), combined with scanning Kelvin probe force microscopy (SKPFM) and morphology analysis. The results showed that the corrosion behavior of NAB was closely associated with the variation in its complex microstructure after different CE times. Selective phase corrosion played a crucial role in the surface damage before 0.5 h of CE. With the prolongation of CE time, the stripping of κ phases decreased the degree of selective phase corrosion of NAB. As a result, both selective phase corrosion and uniform corrosion presented equal performances after 1 h of CE. However, after CE for 2–5 h, uniform corrosion had a dominant impact on the surface damage of NAB. Eventually, the corrosion mechanism of NAB after different CE times was clarified based on the relevant experimental results.
Evaluation of Fillers for Magnesium Potassium Phosphate Cement (MKPC) for the Encapsulation of Low and Intermediate Level Metallic Radioactive Wastes
Authors: Dieguez Mikel , Ruiz Ana Isabel , Cuevas Jaime , Alonso María Cruz , García-Lodeiro Inés , Fernández Raúl
Published: January 2023

This study investigates the effect of coal fly ash (FA), wollastonite (WO), pumice (PM), and metakaolin (MK) as filler materials in the rheological, mechanical, chemical, and mineralogical properties of a magnesium potassium phosphate cement (MKPC), designed for the encapsulation of low and intermediate level radioactive wastes containing reactive metals. Workability, compression strength, dimensional stability, pH, chemical composition, and mineralogical properties were studied in different pastes and mortars of MKPC with a fixed molar ratio of MgO/KH2PO4 = 1. No new mineral phases were found with the addition of the fillers, denoting their low chemical impact on the MKPC system. Moreover, all formulations with a water/cement mass ratio of <0.65 presented compressive strengths higher than 30 MPa after 90 days, and pH values lower than 8.5, corresponding to the passivation zone of aluminum corrosion.
Preparation of Functionalized Zr-Based MOFs and MOFs/GO for Efficient Removal of 1,3-Butadiene from Cigarette Smoke
Authors: Yang Yunxin , Wang Cong , Zhang Hua , Qian Jiancai , Yang Song , Liao Huiyun , Sun Xuehui , Wang Yipeng , Sun Peijian , Jia Yunzhen , Guo Junwei , Zhu Huaiyuan , Nie Cong
Published: January 2023

Removal of 1,3-butadiene from cigarette smoke plays an important role in human health and environmental protection. Herein, a series of UiO-66 X% containing different ratios of the -NH2 group was synthesized via the solvothermal method by using terephthalic acid (H2BDC) and 2-aminoterephthalic acid (NH2-BDC) as ligands. Using GO as support, a series of UiO-66-NH2/GO Y% were prepared by controlling the ratio of UiO-66-NH2 and GO. The effects of -NH2 and GO contents on the structure and composition of MOFs were investigated. Finally, the different -NH2 contents of UiO-66 X% and the different GO contents of UiO-66-NH2/GO Y% were applied in 1,3-butadiene removal from cigarette smoke. The results showed that UiO-66 X% with the higher contents of -NH2 showed a higher rate of 1,3-butadiene removal, and UiO-66-NH2/GO Y% with the GO contents of 5% showed the highest removal rate of about 33.85%, which was 25.54% higher than that of activated carbon. In addition, the saturation capacity of the adsorbent materials for 1,3-butadiene was as high as 210.01–239.54 mg/g, showing great potential in reducing harmful components in cigarette smoke and environmental protection.
A Novel Chitosan Composite Biomaterial with Drug Eluting Capacity for Maxillary Bone Regeneration
Authors: Giordano-Kelhoffer Barbara , Rodríguez-Gonzalez Raquel , Perpiñan-Blasco Marina , Buitrago Jenifer O. , Bosch Begoña M. , Perez Roman A.
Published: January 2023

Bone grafting is one of the most commonly performed treatments for bone healing or repair. Autografts, grafts from the same patient, are the most frequently used bone grafts because they can provide osteogenic cells and growth factors at the site of the implant with reduced risk of rejection or transfer of diseases. Nevertheless, this type of graft presents some drawbacks, such as pain, risk of infection, and limited availability. For this reason, synthetic bone grafts are among the main proposals in regenerative medicine. This branch of medicine is based on the development of new biomaterials with the goal of increasing bone healing capacity and, more specifically in dentistry, they aim at simultaneously preventing or eliminating bacterial infections. The use of fibers made of chitosan (CS) and hydroxyapatite (HA) loaded with an antibiotic (doxycycline, DX) and fabricated with the help of an injection pump is presented as a new strategy for improving maxillary bone regeneration. In vitro characterization of the DX controlled released from the fibers was quantified after mixing different amounts of HA (10–75%). The 1% CS concentration was stable, easy to manipulate and exhibited adequate cuttability and pH parameters. The hydroxyapatite concentration dictated the combined fast and controlled release profile of CSHA50DX. Our findings demonstrate that the CS-HA-DX complex may be a promising candidate graft material for enhancing bone tissue regeneration in dental clinical practice.
Preparation of Ganoderma Lucidum Bran-Based Biological Activated Carbon for Dual-Functional Adsorption and Detection of Copper Ions
Authors: Wang Baoying , Lan Jingming , Bo Chunmiao , Gong Bolin , Ou Junjie
Published: January 2023

In this paper, Ganoderma lucidum bran was explored as the precursor to fabricate biomass activated carbon. When potassium hydroxide was selected as an activator (1:6, mass ratio of AC-12 to potassium hydroxide), and the activation condition was 700 °C at 5 h, the highest specific surface area reached 3147 m2 g−1. Carbon dots were prepared with citric acid monohydrate and thiourea as precursors and then loaded onto the surface of activated carbon by a simple and green method. Activated carbon for dual-functional had a high adsorption capacity. Additionally, based on its unique optical properties, the fluorescence response for detecting copper ion was established. The fluorescence intensity of the materials decreased linearly with the increase of copper ion concentration, in the range of 10–50 nmol L−1. The research opened up a new way for applying biomass activated carbon in the field of adsorption and detection. Highlights: (1) Carbon dots were loaded on the surface of activated carbon; (2) the simultaneous adsorption and detection were realized; (3) it provides a way for the preparation of dual-functional materials.
Simulation and Experimental Verification of Die Quenching Deformation of Aviation Carburized Face Gear
Authors: Liu Huaming , Zhao Jiuyue , Tang Jinyuan , Shao Wen , Sun Beier
Published: January 2023

The tooth width and length of face gear limit control the strength of face gear, and heat treatments are often used to improve the hardness and strength of face gear. However, heat treatments will often cause additional deformations, which will affect the dimensional accuracy of the face gear. In this paper, to effectively control the deformation and ensure the accuracy of the face gear, the finite element method was used to establish the calculation model of the face gear die quenching method, and thus, the influence of die on the gear quenching deformation was analyzed. Next, the accuracy of the calculation model was verified by the pressure quenching experiment. The results demonstrated that the inconsistent phase transformation between the surface and the center of the face gear was the key factor affecting the deformation due to the influence of the carbon content. Compared with die-less quenching, the inner hole-die can effectively limit the radial shrinkage deformation of the face gear. With the increase of the upper-die pressure, the axial and radial deformations of the face gear gradually became stable. In the actual production, the load of dies should be reasonably selected based on the gear accuracy requirements.
Life Cycle Environmental Impact Assessment and Applicability of Synthetic Resin Formwork
Authors: Nam Kyung-Yong , Lim Myung-Kwan
Published: January 2023

In this study, the environmental impacts of the production and field application of synthetic resin formwork were quantitatively compared to the Euro form. The noise test results showed an average of 107.3 dB (A) for the Euro form and 99.7 dB (A) for the synthetic resin formwork. Additionally, when the number of uses was considered, the CO2 emissions from the synthetic resin formwork were approximately 32% lower than the Euro form. Based on these results, it is expected that the use of synthetic resin formwork will reduce material production by half and reduce CO2 emissions compared to channel formwork.
Experimental Study on Toughness of Engineered Cementitious Composites with Desert Sand
Authors: Lv Zhishuan , Han Yang , Han Guoqi , Ge Xueyu , Wang Hao
Published: January 2023

In this paper, engineered cementitious composites (ECCs) were prepared with desert sand instead of ordinary sand, and the toughness properties of the ECCs were studied. The particle size of the desert sand was 0.075–0.3 mm, which is defined as ultrafine sand. The ordinary sand was sieved into one control group with a size of 0.075–0.3 mm and three other reference groups. Together with the desert sand group, a total of five groups of ECC specimens were created. Through a uniaxial tensile test, three-point bending test and single-seam tensile test on the ECC specimens, the influence of aggregate particle size and sand type on the ECC tensile strength, deformation capacity, initial crack strength, cement-matrix-fracture toughness, multiple cracking characteristics and strain-hardening properties were studied. The experimental results show that the 28d tensile strain of the four groups of the ordinary sand specimens was 8.13%, 4.37%, 4.51% and 4.23%, respectively, which exceeded 2% and satisfied the requirements for the minimum strain of the ECCs. It is easier to achieve the ECC strain hardening with sand with a fine particle size; thus, a particle size below 0.3 mm is preferred when preparing the ECCs to achieve a high toughness. The multiple cracking performance (MCP) and the pseudostrain hardening (PSH) of desert sand and ordinary sand with a 0.075–0.3 mm grain size were 2.88 and 2.33, and 8.76 and 8.17, respectively, all of which meet the strength criteria and energy criteria and have similar properties. The tensile strength and tensile deformation of the desert sand group were 4.97 MPa and 6.78%, respectively, and the deformation capacity and strain–strengthening performance were outstanding. It is verified that it is feasible to use desert sand instead of ordinary sand to prepare the ECCs.
Computational Modeling of Doped 2D Anode Materials for Lithium-Ion Batteries
Authors: Galashev Alexander
Published: January 2023

Development of high-performance lithium-ion batteries (LIBs) is boosted by the needs of the modern automotive industry and the wide expansion of all kinds of electronic devices. First of all, improvements should be associated with an increase in the specific capacity and charging rate as well as the cyclic stability of electrode materials. The complexity of experimental anode material selection is now the main limiting factor in improving LIB performance. Computer selection of anode materials based on first-principles and classical molecular dynamics modeling can be considered as the main paths to success. However, even combined anodes cannot always provide high LIB characteristics and it is necessary to resort to their alloying. Transmutation neutron doping (NTD) is the most appropriate way to improve the properties of thin film silicon anodes. In this review, the effectiveness of the NTD procedure for silicene/graphite (nickel) anodes is shown. With moderate P doping (up to 6%), the increase in the capacity of a silicene channel on a Ni substrate can be 15–20%, while maintaining the safety margin of silicene during cycling. This review can serve as a starting point for meaningful selection and optimization of the performance of anode materials.
Performance of Manufactured and Recycled Steel Fibres in Restraining Concrete Plastic Shrinkage Cracks
Authors: Alshammari Talal O. , Pilakoutas Kypros , Guadagnini Maurizio
Published: January 2023

Early-age plastic shrinkage cracks can reduce the durability of concrete slabs by creating direct paths for the ingress of aggressive agents and thus accelerating degradation due to environmental attack, in particular, in hot and windy environments. The elimination of such cracks is essential for durable and sustainable concrete structures. This paper parametrically investigates the effect of manufactured steel fibres (MSF) and recycled tyre steel fibres (RTSF) on restraining plastic shrinkage and micro cracks at different dosages (10, 20, and 30 kg/m3). The plastic shrinkage tests were carried out in a specially designed chamber, according to ASTM C1579. Various environmental conditions are examined, and their impact on compressive strength and crack potential is assessed. A digital image analysis technique is used to measure length, width, and the area of the crack on the exposed surface to gain additional insights into crack behaviour. The results show a slight early-age (one-day) increase in compressive strength for the concrete exposed to the various environmental conditions, mostly as a result of higher temperatures. Through the use of the crack reduction ratio (CRR), both RTSF and MSF are shown to be successful in controlling plastic shrinkage and micro cracks, with the RTSF being superior due to the fact that they are better distributed in the concrete volume. The addition of 30 kg/m3 of RTSF was effective in preventing crack development in most environments or restraining cracks in extremely harsh environments. The adoption of these results will lead to more sustainable concrete slabs in the harsher environmental conditions created by climate change.
Enantiodiscriminating Lipophilic Liquid Membrane-Based Assay for High-Throughput Nanomolar Enantioenrichment of Chiral Building Blocks
Authors: Jávor Bálint , Vezse Panna , Golcs Ádám , Huszthy Péter , Tóth Tünde
Published: January 2023

The reported optical resolution method was designed to support high-throughput enantioseparation of molecular building blocks obtained by automated small-scale synthetic methods. Lipophilic esters of common resolving agents were prepared and used as liquid membranes on the indifferent polymer surface of a microtiter assay. Chiral model compounds were enriched in one of the enantiomers starting from the aqueous solutions of their racemic mixture. Enantiodiscrimination was provided by forming diastereomeric coordination complexes of lipophilic enantiopure esters with the enantiomers of the chiral building blocks inside the liquid membranes. This enantiomeric recognition resulted in a greater distribution ratio of the preferred isomer in the membrane phase, thus the process enables a simultaneous enantioenrichment of the solutions outside the membrane. This paper reports a novel microplate-integrated stereoselective membrane enrichment technique satisfying the need for automatable enantioseparation on a subpreparative scale.
Design of 4 × 4 Low-Profile Antenna Array for CubeSat Applications
Authors: Jiménez Diana Alondra , Reyna Alberto , Balderas Luz Idalia , Panduro Marco Antonio
Published: January 2023

This paper presents a low-profile microstrip antenna with high gain for fifth-generation (5G) CubeSat applications. The proposed design consists of 16 miniaturized patch antennas distributed in a uniform 4 × 4 topology with a feeding network on Rogers TMM10 substrate. The antenna array was simulated in CST Studio Suite® software and fabricated for performance testing on the CubeSat structure. The prototype works perfectly from 3.46 GHz to 3.54 GHz. The simulated and measurement results reveal remarkable performance. The design obtained a measured gain of 8.03 dBi and a reflection coefficient of −17.4 dB at the center frequency of 3.5 GHz. Due to its reduced dimensions of 10 × 10 cm, this design is an excellent alternative for mounting on a CubeSat structure as it combines efficient performance with a low profile.
Designing a Microfluidic Chip Driven by Carbon Dioxide for Separation and Detection of Particulate Matter
Authors: Wang Ruofei , Zhao Heng , Wang Xingbo , Li Jiaqi
Published: January 2023

Atmospheric particulate pollution poses a great danger to the environment and human health, and there is a strong need to develop equipment for collecting and separating particulate matter of different particle sizes to study the effects of particulate matter on human health. A virtual impactor is a particle separation device based on the principle of inertial separation which provides scientific guidance for identifying the composition characteristics of particles. Much existing virtual impactor research focuses on the design of structural dimensions with little exploration of the effect of fluid properties on performance. In this paper, a microfluidic chip with a cutoff diameter of 1.85 µm was designed based on computational fluid dynamics and numerically simulated via finite element analysis to analyze important parameters such as inlet flow rate, splitting ratio and fluid properties. By numerical simulation of the split ratio, we found that the obtained collection efficiency curves could not be combined into one characteristic curve by the Stk0.5 scaling method. We therefore propose a modified Stokes number equation for predicting the cutoff diameter at different splitting ratios. The collection efficiency curves of different fluids as microfluidic chip media were plotted, and the results show that the cut particle size was reduced from 2.5 µm to 1.85 µm after replacing conventional fluid air with CO2 formed by dry ice sublimation. This is a decrease of approximately 26%, which is superior to other existing methods for reducing the cutoff diameter.
Editorial for Special Issue “Environmental Geochemistry in the Mining Environment”
Authors: Plante Benoît , Pabst Thomas , Wilson David
Published: January 2023

The demand for minerals has never been so high and is expected to increase in the coming decades [...]
Advanced Fractionation of Kraft Lignin by Aqueous Hydrotropic Solutions
Authors: Gaspar Rita , Muguet Marcelo Coelho dos Santos , Fardim Pedro
Published: January 2023

Lignin is an underutilized high-potential biopolymer that has been extensively studied over the past few decades. However, lignin still has drawbacks when compared with well-known petroleum-based equivalents, and the production of tailored lignin fractions is highly in demand. In this work, a new method for the fractionation of Lignoboost Kraft Lignin (LKL) is proposed by using two different hydrotropes: sodium xylenesulfonate (SXS) and sodium cumenesulfonate (SCS). The different fractions are obtained by sequentially decreasing the hydrotropic concentration with the addition of water. Four and three different fractions were retrieved from the use of SXS and SCS, respectively. The LKL and respective fractions were analysed, and compared by GPC, FTIR-ATR, 1H-NMR, 13C-NMR, 31P NMR, 2D HSQC and SEM. The fractions showed different molecular weights, polydispersity, and amount of functional groups. Our water-based lignin fractionation platform can potentially be combined with different lignin extraction and processing technologies, with the advantage of hydrotrope recycling.
Unveiling the Chemistry and Synthetic Potential of Catalytic Cycloaddition Reaction of Allenes: A Review
Authors: Sikandar Sana , Zahoor Ameer Fawad , Ghaffar Abdul , Anjum Muhammad Naveed , Noreen Razia , Irfan Ali , Munir Bushra , Kotwica-Mojzych Katarzyna , Mojzych Mariusz
Published: January 2023

Allenes with two carbon–carbon double bonds belong to a unique class of unsaturated hydrocarbons. The central carbon atom of allene is sp hybridized and forms two σ-bonds and two π-bonds with two terminal sp2 hybridized carbon atoms. The chemistry of allenes has been well documented over the last decades. They are more reactive than alkenes due to higher strain and exhibit significant axial chirality, thus playing a vital role in asymmetric synthesis. Over a variety of organic transformations, allenes specifically undergo classical metal catalyzed cycloaddition reactions to obtain chemo-, regio- and stereoselective cycloadducts. This review briefly describes different types of annulations including [2+2], [2+2+1], [3+2], [2+2+2], [4+2], [5+2], [6+2] cycloadditions using titanium, cobalt, rhodium, nickel, palladium, platinum, gold and phosphine catalyzed reactions along with a mechanistic study of some highlighted protocols. The synthetic applications of these reactions towards the synthesis of natural products such as aristeromycin, ent-[3]-ladderanol, waihoensene(−)-vindoline and (+)-4-epi-vindoline have also been described.
Indole Derivatives Bearing Imidazole, Benzothiazole-2-Thione or Benzoxazole-2-Thione Moieties—Synthesis, Structure and Evaluation of Their Cytoprotective, Antioxidant, Antibacterial and Fungicidal Activities
Authors: Jasiewicz Beata , Babijczuk Karolina , Warżajtis Beata , Rychlewska Urszula , Starzyk Justyna , Cofta Grzegorz , Mrówczyńska Lucyna
Published: January 2023

In the search for new bioactive compounds, a methodology based on combining two molecules with biological properties into a new hybrid molecule was used to design and synthesize of a series of ten indole derivatives bearing imidazole, benzothiazole-2-thione, or benzoxazole-2-thione moieties at the C-3 position. The compounds were spectroscopically characterized and tested for their antioxidant, antibacterial, and fungicidal activities. The crystal structures were determined for five of them. Comparison of the closely related structures containing either benzothiazole-2-thione or benzoxazole-2-thione clearly shows that the replacement of -S- and -O- ring atoms modify molecular conformation in the crystal, changes intermolecular interactions, and has a severe impact on biological activity. The results indicate that indole-imidazole derivatives with alkyl substituent exhibit an excellent cytoprotective effect against AAPH-induced oxidative hemolysis and act as effective ferrous ion chelating agents. The indole-imidazole compound with chlorine atoms inhibited the growth of fungal strains: Coriolus versicolor (Cv), Poria placenta (Pp), Coniophora puteana (Cp), and Gloeophyllum trabeum (Gt). The indole-imidazole derivatives showed the highest antibacterial activity, for which the largest growth-inhibition zones were noted in M. luteus and P. fluorescens cultures. The obtained results may be helpful in the development of selective indole derivatives as effective antioxidants and/or antimicrobial agents.
Quantification and Validation of an HPLC Method for Low Concentrations of Apigenin-7-O-Glucuronide in Agrimonia pilosa Aqueous Ethanol Extract Topical Cream by Liquid–Liquid Extraction
Authors: Lee Jin Seok , Nam Yu Ran , Kim Hyun Jong , Kim Woo Kyung
Published: January 2023

In this study, we aimed to develop and validate a pretreatment method for separating and analyzing the small amounts of biomarkers contained in topical cream formulations. Analyzing semisolid formulations that contain low concentrations of active ingredients is difficult. Cream formulations containing an aqueous ethanol extract of 0.1% Agrimonia pilosa is an example. Approximately 0.0013% of apigenin-7-O-glucuronide(A7OG) was contained as a biomarker in the cream. To determine the A7OG content present in the cream formulation, liquid–liquid extraction using dichlormethane was applied. In addition, the volume of the distribution liquid was measured using the peak ratios of the indicator component, A7OG, and an internal standard, baicalin. Subsequently, the A7OG content in the cream formulation was calculated. Using this time-saving method, A7OG can be simply analyzed without additional pretreatment steps, such as evaporation and reconstitution. Moreover, the validation results confirmed that this analytical method met all of the criteria. Consequently, A7OG was successfully isolated from the cream, analyzed, and quantified using the developed method.
Effect of Liquefaction of Honey on the Content of Phenolic Compounds
Authors: Hájek Tomáš
Published: January 2023

Thermal liquefaction at low temperature is very time consuming and microwaves or an ultrasonic bath can be used to accelerate the process of dissolving sugar crystals. Phenolic compounds, such as phenolic acids or flavonoids, are an important group of secondary metabolites of plants and become honey from the nectar of blossoms. In this study, how the content of phenolic acids and flavones in honey were affected by liquefaction of honey using a microwave oven was studied. The concentration of tested compounds in untreated honey and in honey liquefied in a hot water bath, ultrasonic bath and microwave oven at four microwave power levels were determined by reversed phase liquid chromatography combined with multichannel electrochemical detection. A significant decrease in the content of all compounds was observed for all melting treatments. The phenolic compounds concentration decreased on average by 31.1–35.5% using microwave at intensities 270, 450 and 900 W and the time required for the sugar crystal melting was more than 20 times less than in the case of the 80 °C water bath. The temperature of samples after the end of microwave liquefaction was 76–89 °C. Significantly higher losses of phenolic compounds were observed during ultrasound treatment (48.5%), although the maximum temperature of honey was 45 °C, and at the lowest microwaves power (50.6%).
Use of Refractance Window Drying as an Alternative Method for Processing the Microalga Spirulina platensis
Authors: Silva Neiton C. , Freitas Luis V. D. , Silva Thaise C. , Duarte Claudio R. , Barrozo Marcos A. S.
Published: January 2023

Microalgae such as Spirulina platensis have recently attracted the interest of the pharmaceutical, nutritional and food industries due to their high levels of proteins and bioactive compounds. In this study, we investigated the use of refractance window (RW) drying as an alternative technology for processing the microalga Spirulina biomass aiming at its dehydration. In addition, we also analyzed the effects of operating variables (i.e., time and temperature) on the quality of the final product, expressed by the content of bioactive compounds (i.e., total phenolics, total flavonoids, and phycocyanin). The results showed that RW drying can generate a dehydrated product with a moisture content lower than 10.0%, minimal visual changes, and reduced process time. The content of bioactive compounds after RW drying was found to be satisfactory, with some of them close to those observed in the fresh microalga. The best results for total phenolic (TPC) and total flavonoids (TFC) content were obtained at temperatures of around 70 °C and processing times around 4.5 h. The phycocyanin content was negatively influenced by higher temperatures (higher than 80 °C) and high exposing drying times (higher than 4.5 h) due to its thermosensibility properties. The use of refractance window drying proved to be an interesting methodology for the processing and conservation of Spirulina platensis, as well as an important alternative to the industrial processing of this biomass.
Does NUCB2/Nesfatin-1 Influence Eating Behaviors in Obese Patients with Binge Eating Disorder? Toward a Neurobiological Pathway
Authors: Caroleo Mariarita , Carbone Elvira Anna , Arcidiacono Biagio , Greco Marta , Primerano Amedeo , Mirabelli Maria , Fazia Gilda , Rania Marianna , Hribal Marta Letizia , Gallelli Luca , Foti Daniela Patrizia , De Fazio Pasquale , Segura-Garcia Cristina , Brunetti Antonio
Published: January 2023

Nesfatin-1 is a new anorexigenic neuropeptide involved in the regulation of hunger/satiety, eating, and affective disorders. We aimed to investigate nesfatin-1 secretion in vitro, in murine adipose cells, and in human adipose fat samples, as well as to assess the link between circulating nesfatin-1 levels, NUCB2 and Fat Mass and Obesity Gene (FTO) polymorphisms, BMI, Eating Disorders (EDs), and pathological behaviors. Nesfatin-1 secretion was evaluated both in normoxic fully differentiated 3T3-L1 mouse adipocytes and after incubation under hypoxic conditions for 24 h. Omental Visceral Adipose tissue (VAT) specimens of 11 obese subjects, and nesfatin-1 serum levels’ evaluation, eating behaviors, NUCB2 rs757081, and FTO rs9939609 polymorphisms of 71 outpatients seeking treatment for EDs with different Body Mass Index (BMI) were studied. Significantly higher levels of nesfatin-1 were detected in hypoxic 3T3-L1 cultured adipocytes compared to normoxic ones. Nesfatin-1 was highly detectable in the VAT of obese compared to normal-weight subjects. Nesfatin-1 serum levels did not vary according to BMI, sex, and EDs diagnosis, but correlations with grazing; emotional, sweet, and binge eating; hyperphagia; social eating; childhood obesity were evident. Obese subjects with CG genotype NUCB2 rs757081 and AT genotype FTO rs9939609 polymorphisms had higher nesfatin-1 levels. It could represent a new biomarker of EDs comorbidity among obese patients.
Exploration of the Nutritional and Functional Properties of Underutilized Grains as an Alternative Source for the Research of Food-Derived Bioactive Peptides
Authors: Fernández-Tomé Samuel , Ashaolu Tolulope Joshua , Hernández-Ledesma Blanca
Published: January 2023

The estimated increase in world population will lead to a deterioration in global food security, aggravated in developing countries by hidden hunger resulting from protein deficiency. To reduce or avoid this crisis, a dietary shift towards the consumption of sustainable, nutrient-rich, and calorically efficient food products has been recommended by the FAO and WHO. Plant proteins derived from grains and seeds provide nutritionally balanced diets, improve health status, reduce poverty, enhance food security, and contain several functional compounds. In this review, the current evidence on the nutritional and functional properties of underutilized grains is summarized, focusing on their incorporation into functional foods and the role of their proteins as novel source of bioactive peptides with health benefits.
Changes in Eating Behaviors and Their Associations with Weight Loss in Japanese Patients Who Underwent Laparoscopic Sleeve Gastrectomy
Authors: Kimura Yu , Fujishima Yuya , Nishizawa Hitoshi , Saito Takuro , Miyazaki Yasuhiro , Shirahase Keiko , Tokuzawa Chie , Nagai Naoko , Fukuda Shiro , Maeda Kazuhisa , Maeda Norikazu , Doki Yuichiro , Shimomura Iichiro
Published: January 2023

Background: Metabolic and bariatric surgery (MBS) has been established to provide long-term weight loss in severe obesity. In this study, we investigated the factors that affect post-operative weight loss, with a particular focus on changes in eating behaviors. Methods: Time-course changes in body weight and eating behaviors were examined in 49 Japanese patients who underwent laparoscopic sleeve gastrectomy from the first visit to 12 months after surgery. Each eating behavior was evaluated via the questionnaire of the Japan Society for the Study of Obesity. Results: Pre-operative weight reduction mediated by dietary and lifestyle interventions showed significant positive correlations with weight loss outcomes at 12 months after surgery. We observed significant decreases in scores for most of the eating behaviors 12 months after surgery. However, “emotional eating behavior” scores declined temporarily in the early post-operative period of one month but thereafter returned to the pre-operative level at 12 months. Furthermore, increases in the scores for “emotional eating behavior” and “sense of hunger” from 1 to 12 months post-operatively were significantly associated with poor weight loss. Conclusions: Our results demonstrate the beneficial effects of MBS on obesity-related eating behaviors, as well as highlighting “emotional eating behavior” as requiring particular attention.
Dose-Related Regulatory Effect of Raspberry Polyphenolic Extract on Cecal Microbiota Activity, Lipid Metabolism and Inflammation in Rats Fed a Diet Rich in Saturated Fats
Authors: Fotschki Bartosz , Cholewińska Ewelina , Ognik Katarzyna , Sójka Michał , Milala Joanna , Fotschki Joanna , Wiczkowski Wiesław , Juśkiewicz Jerzy
Published: January 2023

The amount of berry polyphenols required to exert health-promoting effects seems to be difficult to achieve by fresh fruit ingestion, so polyphenol-rich extracts could be considered a dietary alternative. In the present study, laboratory rats were fed high-fat diets supplemented with 0.1 or 0.3% raspberry polyphenols from pomace, with the former dose reflecting the amount of polyphenols consumed with a glass of fresh raspberries. It was hypothesized that beneficial changes in blood and hepatic tissue related to lipid metabolism would accompany both treatments, but the health-promoting effect would be more noticeable with the higher dose of extract. This hypothesis was confirmed, and the high dose of raspberry polyphenols was better than the low dose extract in terms of decreased epididymal white adipose tissue weight, hepatic triglyceride content, PPARγ and SREBP-1c expression in the liver, and plasma IL-6 concentration, as well as increased acetic acid concentration in the cecal digesta. These effects might be partially associated with the enhanced content of ellagitannin and anthocyanin metabolites found in the blood plasma of rats administered the high dose of the extract. The results showed that this extract could be considered a dietary vehicle to provide an amount of raspberry polyphenols that could promote health.
Dihydromyricetin Protects Intestinal Barrier Integrity by Promoting IL-22 Expression in ILC3s through the AMPK/SIRT3/STAT3 Signaling Pathway
Authors: Zhou Jie , Yue Jing , Yao Yu , Hou Pengfei , Zhang Ting , Zhang Qianyong , Yi Long , Mi Mantian
Published: January 2023

Background: Previous studies indicate that dihydromyricetin (DHM) could alleviate intestinal inflammation and improve intestinal barrier integrity, yet the underlying mechanism remains obscure. Methods: C57BL/6 male mice were fed with a control diet, high-fat diet (HFD), or HFD + DHM diet for 12 weeks. The intestinal permeability and expression of intestinal tight junction (TJ) protein were detected to evaluate the effects of DHM on intestinal barrier integrity. The interleukin 22 (IL-22) production of group 3 innate lymphoid cells (ILC3s) in small intestine lamina propria was tested to clarify the effects of DHM on ILC3s. In addition, an MNK3 cell line, which expresses the same transcription factors and cytokines as ILC3, was used to investigate the molecular mechanism under DHM-induced IL-22 expression. Results: DHM effectively protected HFD-fed mice against intestinal barrier destruction by promoting ILC3 activation and IL-22 secretion, and IL-22 expression increased the expression levels of TJ molecules to protect intestinal barrier integrity. Moreover, DHM increased activation of the AMPK/SIRT3/STAT3 pathway, which in turn promoted IL-22 expression in MNK3 cells. Conclusions: DHM improved IL-22 production in ILC3 cells to alleviate HFD-induced intestinal barrier destruction via the AMPK/SIRT3/STAT3 pathway.