bluuebunny/crossref_metadata_2025 huggingface dataset:
Understanding the molecular basis of vitiligo - a systematic review
Authors: Osuch Magdalena , Gaik Magdalena , Bogacz Rafał , Uram Ewa , Woźniak Justyna , Womperski Karol , Magda Inga
Published: August 2023

Introduction: Vitiligo is a systemic, chronic, hypopigmented dermatosis

of unclear background. The disease is characterized by the selective loss or dysfunction of melanocytes. As a result we can observe various, well and non-squamous depigmentation areas of different size and shape. The pathogenesis of vitiligo is not fully understood, however, the current view is that the etiopathology of this disease is complex

Purpose of the study: Current treatment models are often nonspecific, so it is important to understand the pathomechanism that can help with vitiligo lesions. It will also sensitize researchers to the search for new therapeutic options

Material and methods: Collected scientific articles and guidelines available online of high substantive value. Expressions that were searched in databases: vitiligo, etiology, leptin, pathogenesis, reactive oxygen species, oxidative stress

Results and conclusions: The scientific papers and researches cited in the article show that the major role is played by cellular stress and reactive oxygen forms, secondary inflammation or environmental factors. Cellular stress activates autoimmune and autoinflammatory mechanisms that destroy pigment cells. Therefore, there are probably even more mechanisms contributing to the development of vitiligo.

Illness can affect the patient 's quality of life. In recent years, there has been significant progress in understanding the pathogenesis of vitiligo. Effective treatment of vitiligo remains a difficult challenge for both scientists and dermatologists.
Emerging Trends in Gel Nail Allergies: Prevalence, Symptoms, and Occupational Hazards Associated with Acrylate Sensitization
Authors: Zembala Patryk , Zembala Julita , Zembala Roksana , Adamowicz Dominik , Gacoń Ewa , Łopuszyńska Inga
Published: August 2023

Introduction and objective

Gel nail allergies have become a growing concern in recent years, as individuals experience adverse immune reactions to the chemicals present in gel nail products. The popularity of gel nails, known for their long-lasting and durable finish compared to traditional nail polishes, has increased in the beauty industry. However, specific constituents, particularly acrylate compounds used in gel nail formulations, can trigger allergic responses in susceptible individuals.

Abbreviated description of the state of knowledge

Findings from the reviewed articles indicate that allergic reactions to acrylates in gel nail products can manifest in various ways, including contact dermatitis, dermatoses, and general allergic responses. Nail technicians, due to their frequent exposure to gel nail products and other potential allergens, are particularly vulnerable to occupational hazards associated with acrylate sensitization. These insights highlight the need for preventive measures to protect the health and well-being of nail technicians and promote a safer working environment.

Summary

This literature review addresses the emerging issue of gel nail allergies and provides valuable information regarding the prevalence and characteristics of allergic reactions to acrylates. The article underscores the significance of increasing awareness, implementing preventive measures, and effectively managing gel nail allergies. By doing so, the beauty industry can ensure a safer approach to gel nail applications, benefitting both nail technicians and consumers alike.
The impact of quantitative and semi-quantitative culture of respiratory tract secretions on clinical decisions in a patient with suspected pneumonia – case study
Authors: Kasprzycka Kamila , Węglarz Marcin , Lewkowicz Martyna , Ratuszny Gracjana
Published: August 2023

Pneumonia is one of the most common disease entities treated in the Intensive Care Unit. The standard diagnostic procedure for patients with suspected pneumonia is to evaluate the presence of symptoms of infection, physical examination, imaging, laboratory and microbiological tests, arterial blood gasometry and culture of respiratory tract secretions. In many Intensive Care Units, the preferred method of collecting material from the lower respiratory tract is an endotracheal aspirate. However, its semi-quantitative culture does not distinguish respiratory tract colonization from infection. Samples obtained by bronchoscopy are believed to be more representative of the presence of true pathogens in the lungs.

An 87-year-old patient with myasthenia gravis was admitted to the Intensive Care Unit for suspected pneumonia. Laboratory tests showed elevated inflammatory markers and a chest X-ray showed interstitial densities in the left lower lobe. The result of semi-quantitative culture of tracheal aspirate was heavy growth of Staphylococcus aureus and heavy growth of Pseudomonas aeruginosa. The result of the quantitative BAL culture was S.aureus MSSA 105 colony-forming unit (CFU) per ml, Pseudomonas aeruginosa 102 CFU/ml. To consider a microorganism responsible for infection, the number of bacteria cells must exceed a designated threshold. For BAL it is ≥104 CFU/ml, for TA it is ≥106 CFU/ml, for PSB it is ≥ 103/ml. In this case, the cutoff point for identifying the pathogen responsible for the infection was reached only by Staphylococcus aureus (105 CFU/ml), not by Pseudomonas aeruginosa (102 CFU/ml).

The final diagnosis was left-sided PN1 pneumonia of S.aureus etiology. A cloxacillin was used for the treatment. Clinical improvement was achieved.

The described case proves the advantage of quantitative culture over semi-quantitative culture of respiratory tract secretions. The advantage of bronchoalveolar lavage over tracheal aspirate is also noticeable.
Knowledge and awareness about colorectal cancer and barriers to its screening among a sample of general public in Saudi Arabia
Authors: Imran Muhammad , Baig Mukhtiar , Alshuaibi Razan Obaidallah , Almohammadi Thikra Abdullah , Albeladi Samah Abdulsalam , Zaafarani Faysal Turki Matuq
Published: August 2023

Introduction

The present study investigated knowledge, awareness, and barriers to colorectal cancer (CRC) screening from a sample of the general population in Saudi Arabia.

Methods

This cross-sectional study was conducted between August 2022 and January 2023 among a sample of the general population in Jeddah, Saudi Arabia. The questionnaire consisted of demographics, knowledge and awareness, and questions about CRC screening barriers.

Results

A total of 1105 adults belonged to the general public [505 females (45.7%) and 600 males (54.3%)] recruited in this survey. The mean age of the respondents was 39.79±12.49. The internet was the primary source of CC information for most participants, 661(59.8%). Gender-wise comparison of general public responses regarding CRC knowledge and awareness and barriers to screening showed a mixed response. Analysis of participants’ knowledge regarding CRC and its risk factors and warning signs showed that 356(32.2%) people believed that the best age for the CRC test is 41–50 years, and 285(25.8%) responded they don’t know. Almost half of the participants, 539(48.8%), were not interested in attending awareness seminars about CRC, while 371(33.6%) were interested in attending awareness seminars about CRC. Only one-third of the respondents, 368(33.3%), knew of any tests or examinations used to detect CRC. Participants’ perceptions about colonoscopy-related and FOBT-related barriers to CRC screening disclosed that these are time-consuming, expensive, painful, embarrassing, etc.

Conclusion

Insufficient information, poor awareness, and several assumed barriers to CRC screening were found among study participants. There is a need to close knowledge gaps and offer them comprehensive information regarding CRC, as well as the availability and benefits of screening. In this aspect, social media can be extremely beneficial.
Black carbon derived PET plastic bottle waste and rice straw for sorption of Acid Red 27 dye: Machine learning approaches, kinetics, isotherm and thermodynamic studies
Authors: Chakraborty Tapos Kumar , Tammim Lamia , Islam Khandakar Rashedul , Nice Md. Simoon , Netema Baytune Nahar , Rahman Md. Sozibur , Sen Sujoy , Zaman Samina , Ghosh Gopal Chandra , Munna Asadullah , Habib Ahsan , Tul-Coubra Khadiza , Bosu Himel , Halder Monishanker , Rahman Md. Aliur
Published: August 2023

This study focuses on the probable use of PET waste black carbon (PETWBC) and rice straw black carbon (RSBC) as an adsorbent for Acid Red 27 (AR 27) adsorption. The prepared adsorbent is characterized by FE-SEM and FT-IR. Batch adsorption experiments were conducted with the influencing of different operational conditions namely time of contact (1–180 min), AR 27 concentration (5–70 mg/L), adsorbent dose (0.5–20 g/L), pH (2–10), and temperature (25–60°C). High coefficient value [PETWBC (R2= 0.94), and RSBC (R2= 0.97)] of process optimization model suggesting that this model was significant, where pH and adsorbent dose expressively stimulus removal efficiency including 99.88, and 99.89% for PETWBC, and RSBC at pH (2). Furthermore, the machine learning approaches (ANN and BB-RSM) revealed a good association between the tested and projected value. Pseudo-second-order was the well-suited kinetics, where Freundlich isotherm could explain better equilibrium adsorption data. Thermodynamic study shows AR 27 adsorption is favourable, endothermic, and spontaneous. Environmental friendliness properties are confirmed by desorption studies and satisfactory results also attain from real wastewater experiments. Finally, this study indicates that PETWBC and RSBC could be potential candidates for the adsorption of AR 27 from wastewater.
Características de los directores selectos vía alta dirección pública (ADP) y sus equipos directivos en la provincia de Llanquihue, Región de Los Lagos, Chile
Authors: Sotomayor Meza Juan Felipe
Published: August 2023

Los directores educativos en Chile han permanecido en su cargo «a perpetuidad» hasta el año 1995 y pasan a concurso público el año 2011, mediante proceso regulado por Alta Dirección Pública (ADP). Algunos estudios los han caracterizado, pero no a sus equipos y menos su nivel de satisfacción en el cargo, desde la perspectiva de las Escuelas Efectivas y del liderazgo. El objetivo de este estudio es el análisis de las características sociodemográficas, nivel de estudios, experiencia directiva, características de sus equipos y nivel de satisfacción en el ejercicio de la función. Del mismo modo, se pretende evaluar las relaciones ejercidas en la gestión y el ejercicio del liderazgo. La metodología utilizada fue de corte cuantitativo y como instrumento de recogida de información se usó un cuestionario electrónico en una muestra (N = 55) conformada por todos los directores de diferentes escuelas en la región X de Chile. Los resultados apuntan a la existencia de directores y equipos con rasgos bastante regulares y buen nivel de satisfacción a excepción de la proyección de sus funciones al ámbito pedagógico.
Serum amyloid A in cats with renal azotemia
Authors: Degenhardt Laura , Dorsch Roswitha , Hartmann Katrin , Dörfelt René
Published: August 2023

Background and Aim: The concentration of the feline acute-phase protein serum amyloid A (SAA) increases in cats with acute inflammatory diseases. However, it is unclear whether SAA concentration increases in cats with azotemic kidney disease or whether it can aid in differentiating acute kidney injury (AKI) from chronic kidney disease (CKD). Similarly, whether SAA concentration can be used as a prognostic marker is also unclear. Therefore, this study aimed to evaluate the SAA concentrations in cats with azotemic kidney disease and determine whether SAA concentrations can be used to differentiate between AKI, CKD, and “acute on CKD” (AoC). In addition, we evaluated whether SAA concentration could serve as a prognostic parameter. Moreover, we determined the correlations between SAA concentration and temperature; creatinine, urea, and albumin concentrations; leukocyte count; and urine protein/creatinine (UP/C). Materials and Methods: Forty-eight client-owned azotemic cats (creatinine >250 μmol/L) were included in this prospective study. Cats with pre- and post-renal azotemia were excluded from the study. The causes of azotemia were differentiated into AKI, CKD, and AoC. The SAA concentrations were analyzed through turbidimetric immunoassay at the time of admission. Data were analyzed using the Mann-Whitney U, Kruskal-Wallis, Chi-Square, Fisher’s exact, and Spearman correlation tests. p ≤ 0.05 was considered statistically significant. Results: Serum amyloid A concentration increased in 5/12 cats with AKI, 7/22 cats with CKD, and 9/14 cats with AoC (p = 0.234). The median SAA concentration in cats with AKI, CKD, and AoC whose SAA concentration was ≥5 mg/L was 174 mg/L (10-281 mg/L), 125 mg/L (6-269 mg/L), and 143 mg/L (7-316 mg/L), respectively (p = 0.697), with no significant differences observed between the groups. The median SAA concentration did not differ significantly between survivors (125 mg/L, 10-316 mg/L) and non-survivors (149 mg/L, 6-281 mg/L; p = 0.915) with SAA concentration ≥5 mg/L. Conclusion: Serum amyloid A concentration increased in 44% of the cats with azotemia. However, it cannot be used to differentiate AKI from CKD or as a prognostic marker. Serum amyloid A concentration was correlated with neutrophil count, albumin concentration, and UP/C, and the presence of comorbidities may influence SAA concentration. Keywords: acute kidney injury, acute-phase protein, chronic kidney disease, International Renal Interest Society grading, uremia.
Evaluation of a novel real-time polymerase chain reaction assay for identifying H3 equine influenza virus in Kazakhstan
Authors: Sandybayev Nurlan , Strochkov Vitaliy , Beloussov Vyacheslav , Orkara Shynggys , Kydyrmanov Aidyn , Khan Yelizaveta , Batanova Zhanat , Kassenov Markhabat
Published: August 2023

Background and Aim: Equine influenza (EI) is a highly contagious disease that causes fever and upper respiratory tract inflammation. It is caused by influenza virus A, belonging to the Orthomyxoviridae family, with subtypes H3N8 and H7N7. This study presents data on the development of a real-time polymerase chain reaction (RT-PCR) assay using TaqMan probes to detect the H3 subtype of EI virus (EIV).

Materials and Methods: The evaluation of the developed RT-PCR assay involved five strains of EIV as positive controls and ten nasopharyngeal swab samples collected from horses. RNA was isolated using the GeneJet Viral DNA and RNA Purification Kit, and primers and probes were designed using the Integrated DNA Technology PrimerQuest Tool. The assay was optimized by investigating the annealing temperature, primer and probes concentrations, sensitivity, and specificity. Sequencing was performed using the Thermo Fisher 3130 Genetic Analyzer, and the evolutionary history was inferred using the Neighbor-Joining method.

Results: The designed primers and probes, targeting the H3 gene, were found to be specific to the EIV. The RT-PCR assay was capable of detecting as low as 50 femtogram (f) or 3 × 103 copies of genomic RNA. No cross-reactions were observed with other respiratory viral and bacterial pathogens, indicating the high specificity of the assay. To evaluate its effectiveness, ten nasopharyngeal swab samples collected from farms in North Kazakhstan regions during disease monitoring were analyzed. The accuracy of the analysis was confirmed by comparing the results with those obtained from a commercial RT-PCR assay for EI identification. The developed RT-PCR assay exhibited high sensitivity and specificity for detecting the EIV.

Conclusion: The results demonstrate that the developed RT-PCR assay is suitable for diagnosing EI. This simple, highly sensitive, and specific assay for detecting H3 EIV can be a reliable tool for diagnosing and surveilling EI. Implementing this RT-PCR assay in veterinary practice will enhance and expedite the timely response to potential outbreaks of EI, thus positively impacting the overall epizootic well-being of EI in Kazakhstan.

Keywords: equine influenza, hemagglutinin, horses, primers, probe, real-time polymerase chain reaction assay, virus.
Perempuan dalam Gerakan Lintas Iman
Authors: Nelwan Gerry
Published: August 2023

Today, various inter-faith communities have been born with massive efforts to build peace and harmony, starting at the national and regional levels under government and independent institutions. However, there is something important to note again: not many communities across Indonesia pay attention to the involvement of women as the main actors in the peace-building process. This study aims to analyse the involvement of women in interfaith communities as part of gender justice, especially in the city of Manado. The research process was carried out using descriptive and qualitative methods through library research. Data were obtained through various scientific literature, journals, and books, as well as supporting documents, to write information related to the research. From this research, it was found that there are still a few interfaith communities that accommodate women, but for the context of Manado City itself, this community has not yet been found. The availability of spaces such as interfaith communities for women is an effort to encourage women's active involvement in building peace based on their strategies and approaches.
[Dewasa ini lahir berbagai komunitas lintas iman dengan upaya membangun perdamaian dan kerukunan sangat masif dilakukan mulai dari taraf nasional dan daerah, di bawah lembaga pemerintah maupun yang bersifat independen. Namun ada yang penting untuk diperhatikan kembali, bahwa tidak banyak dari komunitas lintas di Indonesia yang memberi perhatian pada keterlibatan perempuan sebagai aktor utama dalam proses pembangunan perdamaian. Penelitian ini bertujuan untuk menganalisis keterlibatan perempuan dalam komunitas lintas iman sebagai bagian dari keadilan gender, khususnya yang ada di Kota Manado. Proses penelitian ini dilakukan dengan metode kualitatif deskriptif melalui studi kepustakaan. Data yang didapat melalui berbagai literatur ilmiah, jurnal, buku dan juga dokumen pendukung hingga informasi tertulis yang memiliki keterkaitan dengan penelitian tersebut. Dari penelitian ini ditemukan bahwa masih sedikit komunitas lintas iman yang mengakomodir perempuan, untuk konteks Kota Manado sendiri belum ditemukan komunitas tersebut. Ketersediaan ruang seperti komunitas lintas iman bagi perempuan menjadi satu upaya dalam mendorong keterlibatan aktif perempuan untuk membangun perdamaian berdasarkan strategi dan pendekatan nya sendiri.]
Creating Religious Relationality in Digital Media Platform
Authors: Dewantri Puja
Published: August 2023

Today's digital era has manifested a massive movement of people from an old society to a new society. This digital world has also changed the way people see and practise religion. Here, at least two questions are asked. First, consider how the use and accessibility of digital media affect religious knowledge and practise in order to raise religious awareness. The second question is how religion can be both a social practise and a discourse so that more people can participate in the discussion. This research aims to answer these two questions by adopting the indigenous religion paradigm which based on relationality. Indirectly, the main objective of this research is to figure out the interactions related to religious content in digital media as an up-to-date portrait of how religiosity is understood using the alternative of the religious paradigm as the embodiment of new topics in religious studies and the digital world: religious relationality paradigm. Through the three principles of the paradigm—responsibility, ethics, and reciprocity—digital media has helped to create distinctive religious awareness.
[Era digital saat ini telah mewujudkan perpindahan masyarakat secara masif dari masyarakat lama ke masyarakat baru. Dunia digital ini juga telah mengubah perspektif dan praktik seseorang dalam kehidupan beragama. Karenannya, dalam artikel ini, setidaknya terdapat dua pertanyaan yang diajukan. Pertama, bagaimana penggunaan dan aksesibilitas media digital memengaruhi pengetahuan dan praktik keagamaan untuk meningkatkan kesadaran beragama. Pertanyaan kedua adalah bagaimana agama dapat menjadi praktik sosial sekaligus wacana sehingga lebih banyak orang dapat berpartisipasi dalam diskusi keagamaan. Penelitian ini bertujuan untuk menjawab kedua pertanyaan tersebut dengan mengadopsi paradigma agama lokal yang berbasis relasionalitas. Secara tidak langsung tujuan utama dari penelitian ini adalah untuk mengetahui interaksi terkait konten keagamaan dalam media digital sebagai potret terkini bagaimana religiusitas dipahami dengan menggunakan alternatif paradigma keagamaan sebagai pengejawantahan topik baru dalam kajian agama dan dunia digital: paradigma relasionalitas agama. Melalui tiga prinsip paradigma—tanggung jawab, etika, dan timbal balik—media digital telah membantu menciptakan kesadaran beragama yang khas.]
Transformasi Spiritual Masyarakat Jawa Kontemprer
Authors: Yuwono Dandung Budi
Published: August 2023

The life of the Javanese people is full and attached to the mystical world. They are associated with supernatural things, and always do the 'other way'. How to understanding life they perform various rituals, one of which is the ritual on Selasa (Tuesday) Kliwon and Jumat (Friday) Kliwon nights in Parangkusumo. The ritual is an attempt to seek clarity and guidance from the ancestors, namely Panembahan Senopati as the first Islamic Mataram King and Kanjeng Ratu Kidul. This ritual is the embodiment of an 'ingrained' myth about the existence of Kanjeng Ratu Kidul, a spirited creature with powerful powers, the ruler of the southern seas who has enormous supernatural powers, who are believed to be able to give peace to the Javanese people. As a traditional cultural phenomenon, the rituals of the Selasa (Tuesday) Kliwon and Jumat (Friday) Kliwon nights in Parangkusumo are difficult to separate from the daily life of the Javanese. How the ritual process takes place, what is the meaning of the ritual, and is it true that religious identity struggles continue among the Javanese, are the questions that will be answered through this research. This research is a qualitative research using a phenomenological. Data collection techniques were carried out by means of participatory observation and in-depth interviews. The data analysis was done interpretively. Another thing, this research will try to see the common thread between the concept of Islam and the Javanese religion which is considered to have a lot to influence the behavior of the Javanese people.

[Kehidupan masyarakat Jawa, penuh dan lekat dengan dunia mistis. Mereka berhubungan dengan hal-hal gaib, dan senantiasa melakukan ‘jalan lain’. Dalam memahami kehidupan mereka melakukan berbagai ritual, salah satunya ritual malam Selasa Kliwon dan Jumat Kliwon di Parangkusumo. Ritual tersebut merupakan upaya mencari kejernihan dan petunjuk dari leluhur, yakni Panembahan Senopati sebagai Raja Mataram Islam pertama dan Kanjeng Ratu Kidul. Ritual tersebut merupakan perwujudan mitos yang ‘mendarah daging’ tentang keberadaan Kanjeng Ratu Kidul, sosok makhluk halus berkekuatan sakti, penguasa laut selatan yang memiliki kekuatan gaib maha besar, yang diyakini dapat memberi ketentraman bagi masyarakat Jawa. Sebagai fenomena kebudayaan tradisional, ritual malam Selasa Kliwon dan Jumat Kliwon di Parangkusumo sulit dilepaskan dari kehidupan sehari-hari orang Jawa. Bagaimana proses ritual itu berlangsung, apa makna ritual, dan benarkah terus terjadi pergulatan identitas religius pada orang Jawa, adalah pertanyaan-pertanyaan yang akan dijawab melalui penelitian ini. Penelitian ini merupakan penelitian kualitatif dengan menggunakan perspektif fenomenologi. Teknik pengumpulan data dilakukan dengan cara observasi partisipasi dan wawancara mendalam. Adapun analisis data dilakukan secara interpretif. Hal lain, penelitian ini akan coba melihat benang merah antara konsep Islam dengan Agama Jawa yang dianggap banyak mempengaruhi perilaku kehidupan masyarakat Jawa.]
Understanding Frailty in Older Adults: Examining Attributes, Antecedents, and Consequences
Authors:   Jordan University of Science and Technology, Hayajneh Audai A. , Al-Nusour Esraa A , Tawalbeh Raghad , Alsatari Eman S.
Published: August 2023

Background: Frailty has been debated in the literature for three decades, necessitating a comprehensive understanding to guide future research. This study conducts a concept analysis using Walker and Avant's (2011) framework, examining the attributes, antecedents, consequences, and empirical referents of frailty based on a literature review. Aims: This study aims to elucidate the multidimensional nature of frailty, encompassing physical, psychological, and social aspects of older adults' perceptions in later life. The analysis contributes to the conceptual definition of frailty and informs future research. Methods: A concept analysis approach following Walker and Avant's (2011) guidelines was utilized. A thorough literature review was conducted, synthesizing the findings in a matrix. The analysis focused on identifying the attributes, antecedents, consequences, and empirical referents of frailty. Results: Frailty is a multidimensional concept encompassing physical vulnerability, cognitive decline, emotional distress, social isolation, and functional impairment. Antecedents include age-related changes, chronic illnesses, and psychosocial factors. Consequences involve increased healthcare utilization, decreased quality of life, and higher mortality rates. Empirical referents include standardized assessment tools, clinical diagnoses, and self-report measures. Conclusion: Frailty should be understood holistically, addressing physical, psychological, and social dimensions in older adults' lives. This understanding is vital for developing comprehensive interventions and policies to enhance their well-being. The findings establish a foundation for further research on the conceptual definition of frailty and its implications for clinical practice and public health. Implications for Nursing: This conceptual analysis has implications for researchers, healthcare professionals, and policymakers. Recognizing the broader dimensions of frailty enables the development of interventions addressing the complex needs of older adults. Refining assessment tools can capture the multidimensional aspects of frailty accurately. A holistic approach to frailty management should be adopted, guiding the development of targeted interventions to improve older adults' overall well-being. Keywords: Frailty, Older adults, Attributes, Antecedents, Consequences.
Scaling up a diagnostic pause at the ICU-to-ward transition: an exploration of barriers and facilitators to implementation of the ICU-PAUSE handoff tool
Authors: Cornell Ella G. , Harris Emily , McCune Emma , Fukui Elle , Lyons Patrick G. , Rojas Juan C. , Santhosh Lekshmi
Published: August 2023

Objectives

The transition from the intensive care unit (ICU) to the medical ward is a high-risk period due to medical complexity, reduced patient monitoring, and diagnostic uncertainty. Standardized handoff practices reduce errors associated with transitions of care, but little work has been done to standardize the ICU to ward handoff. Further, tools that exist do not focus on preventing diagnostic error. Using Human-Centered Design methods we previously created a novel EHR-based ICU-ward handoff tool (ICU-PAUSE) that embeds a diagnostic pause at the time of transfer. This study aims to explore barriers and facilitators to implementing a diagnostic pause at the ICU-to-ward transition.

Methods

This is a multi-center qualitative study of semi-structured interviews with intensivists from ten academic medical centers. Interviews were analyzed iteratively through a grounded theory approach. The Sittig-Singh sociotechnical model was used as a unifying conceptual framework.

Results

Across the eight domains of the model, we identified major benefits and barriers to implementation. The embedded pause to address diagnostic uncertainty was recognized as a key benefit. Participants agreed that standardization of verbal and written handoff would decrease variation in communication. The main barriers fell within the domains of workflow, institutional culture, people, and assessment.

Conclusions

This study represents a novel application of the Sittig-Singh model in the assessment of a handoff tool. A unique feature of ICU-PAUSE is the explicit acknowledgement of diagnostic uncertainty, a practice that has been shown to reduce medical error and prevent premature closure. Results will be used to inform future multi-site implementation efforts.
Changes in Physical Performance Throughout Professional Soccer Match-Play
Authors: Oliva-Lozano José M. , Granero-Gil Paulino , Panascì Marco
Published: August 2023

Oliva-Lozano, JM, Granero-Gil, P, and Panascì, M. Changes in physical performance throughout professional soccer match-play. J Strength Cond Res 38(1): 123–127, 2024—The aim of this study was to explore the changes in physical performance by playing position throughout professional soccer match-play. Global Positioning Systems were used for the collection of external load measures during 35 matches. Each match was divided into 15-minute periods. Physical performance varied according to the period in distance covered (F = 25.69; p < 0.001; partial eta-squared [ηp2] = 0.11), sprinting distance (SPD, F = 4.35; p < 0.001; ηp2 = 0.02), sprinting actions (SPAs, F = 5.19; p < 0.001), high-intensity accelerations (Acc+3, F = 2.18; p = 0.05; ηp2 = 0.01), high-intensity decelerations (Dec+3, F = 4.51; p < 0.001; ηp2 = 0.02), and high-metabolic load distance (HMLD, F = 5.59; p < 0.001; ηp2 = 0.03). The period with the greatest mean physical performance was usually from the first half of the matches: 0–15 minutes (distance, Acc+3, and Dec+3) and 30–45 minutes (HMLD, SPA, and SPD). However, the lowest mean physical performance compared with the rest of 15-minute periods was observed in the 60–75-minute period (distance, HMLD, Acc+3, and Dec+3), except for SPA and SPD (15–30 minutes and 75–90 minutes). Overall, no significant differences (p > 0.05) were observed in the physical performance between the extratime periods. In addition, the playing position had a significant effect on all performance variables (F = 39.99–133.29; p < 0.001; ηp2 = 0.14–0.34). Central defenders showed the lowest physical performance throughout the periods of match-play, whereas wide midfielders showed the greatest physical performance in all variables, except for distance covered, in which midfielders had the greatest performance. In conclusion, there were changes in physical performance during the matches depending on the period of match-play and playing position.
Feasibility and impact of haplogroup matching for mitochondrial replacement treatment
Authors: Takeda Yuko , Hyslop Louise , Choudhary Meenakshi , Robertson Fiona , Pyle Angela , Wilson Ian , Santibanez‐Koref Mauro , Turnbull Douglass , Herbert Mary , Hudson Gavin
Published: August 2023

Mitochondrial replacement technology (MRT) aims to reduce the risk of serious disease in children born to women who carry pathogenic mitochondrial DNA (mtDNA) variants. By transplanting nuclear genomes from eggs of an affected woman to enucleated eggs from an unaffected donor, MRT creates new combinations of nuclear and mtDNA. Based on sets of shared sequence variants, mtDNA is classified into ~30 haplogroups. Haplogroup matching between egg donors and women undergoing MRT has been proposed as a means of reducing mtDNA sequence divergence between them. Here we investigate the potential effect of mtDNA haplogroup matching on clinical delivery of MRT and on mtDNA sequence divergence between donor/recipient pairs. Our findings indicate that haplogroup matching would limit the availability of egg donors such that women belonging to rare haplogroups may have to wait > 4 years for treatment. Moreover, we find that intra‐haplogroup sequence variation is frequently within the range observed between randomly matched mtDNA pairs. We conclude that haplogroup matching would restrict the availability of MRT, without necessarily reducing mtDNA sequence divergence between donor/recipient pairs.
Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis
Authors: Brown Matthew , Leon Alicia , Kedzierska Katarzyna , Moore Charlotte , Belnoue‐Davis Hayley L , Flach Susanne , Lydon John P , DeMayo Francesco J , Lewis Annabelle , Bosse Tjalling , Tomlinson Ian , Church David N
Published: August 2023

High‐risk endometrial cancer has poor prognosis and is increasing in incidence. However, understanding of the molecular mechanisms which drive this disease is limited. We used genetically engineered mouse models (GEMM) to determine the functional consequences of missense and loss of function mutations inFbxw7,PtenandTp53, which collectively occur in nearly 90% of high‐risk endometrial cancers. We show thatTrp53deletion and missense mutation cause different phenotypes, with the latter a substantially stronger driver of endometrial carcinogenesis. We also show thatFbxw7missense mutation does not cause endometrial neoplasia on its own, but potently accelerates carcinogenesis caused byPtenloss orTrp53missense mutation. By transcriptomic analysis, we identify LEF1 signalling as upregulated inFbxw7/FBXW7‐mutant mouse and human endometrial cancers, and in human isogenic cell lines carryingFBXW7mutation, and validate LEF1 and the additional Wnt pathway effector TCF7L2 as novel FBXW7 substrates. Our study provides new insights into the biology of high‐risk endometrial cancer and suggests that targeting LEF1 may be worthy of investigation in this treatment‐resistant cancer subgroup.
Status and Development Trends of Agricultural Enterprises on the Basis of Private State Support
Authors:   Odessa National Polytechnic University, Balan Alla , Tymoniuk Vladislav ,   Odessa National Polytechnic University, Voloschuk Lidia ,   Odessa National Polytechnic University
Published: August 2023

The article provides an analytical review of the status and development trends of the agricultural enterprises on the basis of private state support in Ukraine. Namely, an analytical review of the agricultural production indicators was conducted: increase (decrease) in the agricultural products volume in the dynamics for January 2018- 2020, gross harvest of grain and leguminous crops covering the period 2009-2020, livestock production for 2019-2020. The analysis of the existing mechanisms and tools for public private support of agricultural producers is carried out: the sizes of the state support of agricultural sector in 2017-2020 are considered, the most actual grant programmes supporting the agricultural producers for 2020 are given.
Tax regulation of flow processes in the chain of the Ukrainian market of grain and bread products
Authors:   Institute of Market Problems and Economic & Ecological Research of the National Academy of Sciences of Ukraine, Nikishyna Oksana
Published: August 2023

The article conducts an empirical study of the processes of formation and fiscal redistribution of value added in the chain of the Ukrainian market of grain and bread products. Structural and financial imbalances in the chain, the share of each link in the formation of market value added and tax revenues are identified. On the basis of interlink balance the comparative analysis of the main indicators of efficiency of links is carried out. It is established that the highest level of tax burden falls on the link of bread production, which has the lowest level of profitability of products in the chain and the highest complexity of value added. On the basis of European practices, measures of optimization of value added taxation in the grain chain, aimed at reducing structural and price imbalances in the market chain, are substantiated.
Management of investment processes in Ukraine at the regional level: the state and problems of improvement
Authors:   Odessa National Polytechnic University, Dobrіanska Natalia , Torishnya Lyudmila ,   Odessa National Polytechnic University, Pulcha Dmitro ,   Odessa National Polytechnic University
Published: August 2023

At the present stage of Ukraine's development, an important role is assigned to regional investment processes. All of them are a necessary condition for stable economic growth of the country, so to speak, in the long run, increase employment and improve the social standard of living. The article analyzes the dynamics of capital investments in Ukraine for the period 2018-2020. Trends in the use of capital investments in terms of individual industries are identified. The peculiarities of the structure of capital investments by types of assets are analyzed. The research of the regional aspect of the mastered capital investments is carried out, the level of investment activity of separate regions is estimated. The main reasons that hinder the establishment of an effective process of investing in the economy of the regions of our country are revealed. The main measures aimed at improving the management of investment processes in Ukraine in general and its regions are outlined.
Classification and peculiarities of the use of urgent instruments of crisis management of enterprises
Authors:   Lviv Polytechnic National University, Yurynets Oksana
Published: August 2023

This article discusses the problem of classification and features of the use of urgent instruments of crisis management of enterprises. As a result of this research, the article provides a classification of such tools on a number of classification criteria: existing (source of origin, place in the management system, cost, the scale of changes envisaged in respect of the object, orientation, types of activities addressed by the tools, the conditions of formation and use, key objectives, coverage, subjective composition of the executors) and new (content, level of novelty for the business environment, the level of individualization for the enterprise, the level of formalization of the tool). Developed classification of urgent crisis management tools deepens understanding of such tools, provides their integrity, as well as specifies processes and driving forces of elimination or reduction of negative influence of crisis phenomena on economic situation of enterprise and provision of its further effective development. The classification will help managers at various management levels in the enterprises to understand from which positions and in which directions they can urgently influence the overcoming of crisis phenomena in their organizations.
Institutionalization of the relationship between government and civil society in the context of management decisions
Authors:   Odessa National Academy of Food Technologies, Briushkova Nataliia , Nikoliuk Olena ,   Odessa National Academy of Food Technologies, Dobrianskа Natalia ,   Odessa National Polytechnic University
Published: August 2023

The article substantiates the directions of improvement of the institutional mechanism of management of relations between the state power and the public. It is established that the involvement of citizens through various forms in the formation and implementation of the institutional mechanism for managing the relationship between government and the public, the process of public decisionmaking reflects a new model of such interaction. A model of using the institutional mechanism for managing the relationship between government and civil society is proposed.
Study of Decentralization Influence on Territories Budget Efficiency
Authors:   Lutsk National Technical University, Vakhovych Iryna , Nedopad Hryhoriy ,   Lutsk National Technical University
Published: August 2023

The article is devoted to scientific and theoretical study of the influence of decentralization reform in Ukraine on the territories budget efficiency. The regulatory legislation aimed at implementing decentralization processes are analyzed. The author's definition of the concept “decentralization” is given. It is proposed to consider decentralization influence on the budget efficiency of territories through the prism of three system-forming components, in particular, administrative and territorial, political and financial aspects. The problem of each of these aspects impact is examined in detail and the functional dependence of budget efficiency on them is determined
Macroeconomic Disparities of Resource Potential in the Regions of Ukraine and Their Addressing
Authors:   Zaporizhzhia Polytechnic National University, Kruglikova Valentina , Bondarenko Olena ,   Zaporizhzhia Polytechnic National University
Published: August 2023

The paper covers resource potential disparity in different regions of Ukraine. The main attention is paid to macroeconomic factors affecting the level of territorial development. The government’s limited financial capacity has resulted in uneven development of regions diminishing their benefits. The degree of social differentiation in different regions is reflected in the dynamics and structure of employment, the level of unemployment, the levels of income and consumption. The ways of creating favorable conditions for territorial development, gaining modern infrastructure, high living standards, and high-quality services are discussed in the paper.
The mechanism for ensuring the national security of Ukraine as an object of targeted impact management
Authors:   Odessa National Polytechnic University, Kulinska Anzhela
Published: August 2023

On the basis of the analysis carried out an important conclusion follows that, in conceptual terms, the mechanism for ensuring the national security of the country is not so much a mechanism for ensuring the interests of the subjects, as a mechanism for ensuring conditions for a safe existence, that is, the conditions that the subject influences and over which he exercises real power. In this regard the article forms a mechanism for ensuring the national security of Ukraine as an object of targeted impact management, it is closed on the process of creating conditions under which the interests of the individual, state and society would be realized, the goals set by them would be based on values. Analysis of the state of national security of the country using a wide range of methodological approaches has proved that the main components of the mechanism for ensuring the national security of Ukraine in the context of transformation are expedient to consider: the goals of the mechanism functioning, which are based on the interests of national security; system of subject-object relations; methods and means of ensuring the national security of the country. It is this understanding of the mechanism for ensuring the national security of Ukraine that will allow it to be considered as an object of targeted impact control.
Digitalization of the agricultural sphere: state, problems and prospects
Authors:   Kyiv National Economic University named after Vadym Hetman, Ligonenko Larysa , Lanova Oksana ,   Kyiv National Economic University named after Vadym Hetman
Published: August 2023

The article argues the relevance of digitalization of the agricultural sector in Ukraine. Digital technologies in the agricultural sector are analyzed on the basis of classification according to their functional purpose. Each of the stages of the digital cycle is described: data collection, data analysis, data storage, data management, data transmission, and sharing. The existing problems of assessing the current state of digitalization of the agricultural sector of Ukraine are highlighted and the analysis of available information characterizing the current state of affairs is carried out. An example of successful implementation of digital processes at Kernel is considered, which clearly indicates that due to digital technologies, the business processes of agricultural enterprises can change radically, increasing the efficiency of its business activities and ensuring competitiveness and development success.
The subjects of civil practice as a basis for democratic transit of Ukraine
Authors: Reznik Oleksandr
Published: August 2023

It has become an axiom in the scientific literature that any civic engagement contributes to democratic transit and the development of civil society. However, different types of this behavior may have different determinants. These may be actions motivated by civic norms and values, but may also be actions driven by financial encouragement or administrative pressure, especially in transitional democracies. The purpose of the study was to identify the impact of modernization values and orientations on different types of civic activism. The author created an indicator where among the options for the answers was offered a list of socio-political measures that were most relevant at the time of the survey. The substantive side of these activities combined the way and the object of communicating their public aspirations and interests. The most common are discussion forms of civil practices that are individualized. These practices do not require much organizational or collective effort and do not require direct interaction with political or governmental institutions. Practices that combine economic activities also have individualized traits, but they require financial costs or sample consumption, so they are less common. Socio-political practices, civic-local practices and protest-demonstration practices are even less common because they require organizational or collective efforts. Five types of civic practices of the Ukrainian population have been empirically identified and their relationship with democracy and liberal values tested. By means of multiple linear regression method, there was found that only civic practices that combine an ethical consumerism, financial donations and political discussions claim that their subjects could be considered as a social basis of Ukraine’s democratic transit. The likelihood of such actions increases with the increase of education levels, decrease of age and living in large settlements. The paradox is that people who profess values of modernization are ready to fund activists, among whom these values are not traced.
UMA ANÁLISE GEOGRÁFICA A PARTIR DO FUTEBOL
Authors: De Aguiar Leal João Antério
Published: August 2023

O ensino de geografia na educação básica visa, sobretudo, a formação de um cidadão crítico, que seja capaz de observar e compreender a realidade à sua volta, tanto em seus aspectos humanos, quanto físicos. Por outro lado, o futebol é, sem dúvidas, o esporte mais popular do planeta, é inegável a influência que ele detém na maior parte do globo. Falar em utilizar esse esporte como uma forma lúdica de trazer determinados assuntos para as aulas de geografia pode ser pensado como algo complexo à primeira vista, mas pode se provar uma boa alternativa para melhorar o processo de ensino-aprendizagem, fugindo da utilização somente do livro didático. Sendo assim, o objetivo central desse trabalho é propor e analisar a utilização do futebol como pontapé de partida para a discussão de alguns conteúdos nas aulas de geografia, buscando provar a importância que o futebol possui não só como esporte, mas como um recurso metodológico eficaz. Através de várias propostas, poderá ser percebido que essa relação entre o futebol e o ensino de geografia é sim possível.