bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and validation of a survival prediction model for patients with esophageal squamous cell carcinoma of the thoracic segment with pT1-2 lymph node metastasis
Authors: Lei Jingle , Ma Keru , Jiang Xiangyu , Bai Yuwen , Fang Chengyuan , Ma Jianqun
Published: October 2023

Background: Research on predicting disease-specific survival (DSS) in patients with esophageal squamous cell carcinoma (ESCC) of the thoracic segment with pT1 to 2 lymph node metastases is insufficient. The nomogram is an excellent tool for individualized assessment. Methods: A total of 146 patients from Harbin Medical University Cancer Hospital were included in the training cohort. 478 patients from the SEER database were included in the validation cohort. Independent risk factors were analyzed through Cox proportional hazards regression, and a nomogram was developed to predict 3- and 5-year DSS. Prognostic efficacy was evaluated using area under the curve (AUC), calibration curves, and decision curve analysis (DCA) and validated in the SEER validation cohort. Results: In the training cohort of 146 cases, the median DSS and IQR (Q1-Q3) for patients with lymph node metastasis was 30.5 months (16.1-67.4 months). In the validation cohort of 478 cases, the median DSS and IQR (Q1-Q3) for patients with lymph node metastasis was 22 months (9-63 months). Predictors of DSS were identified using Cox univariate and multivariate analyses, with pT stage, grade, and chemotherapy identified as significant factors. Conclusion: We created a nomogram. Internal and external validation studies were performed. The time-dependent receiver operating characteristic (ROC) curve and AUC value, calibration curve, and DCA confirmed the high predictive ability of the nomogram. The newly developed nomogram can accurately forecast DSS in patients with thoracic segment ESCC and pT1-2 lymph node metastasis.
Unveiling Distinctive Eye-Tracking Markers to Distinguish Toddlers with High-Risk Autism Spectrum Disorder within an Elevated Risk Toddler Population
Authors: Pachner Orsolya , Soltész Péter , Gyebnár Dóra , Gombos Ferenc , Gerván Patrícia
Published: October 2023

Background
Eye-tracking technology can be utilized to identify early markers of autism. Several atypical features of social attention has been revealed by eye-tracking studies in ASD toddlers. Our objective was to investigate novel eye-tracking variables aimed at distinguishing the ASD group from a population at elevated risk.
Methods
We recorded eye gaze data during the presentation of dynamic social attention stimuli with a self-developed eye-tracking device. We used two types of social attention stimuli: joint attention (ostensive) and preferential looking paradigm. In our research, we analyzed the data of 74 toddlers between 12–30 months (42 nonASD, mean age:22.5 ± 5,0 month; 32 with high-risk ASD (hrASD), mean age 23.3 ± 4,8 month). To examine group differences, we utilized both traditional and innovative eye movement variables, including those based on areas of interest (AOI), Markov variables and gaze retention interval variables (GRI).
Results
As anticipated, we observed significant differences between the two groups across most variables. Typically, within the preferential paradigm, the distinct indicators of the social domain were higher on average in the non-ASD group compared to the hrASD group, while the non-social domain exhibited the opposite trend. In the joint attention paradigm, group differences appeared to be associated with the prompting and ostensive aspects of interpersonal engagement. The hrASD group consistently displayed a lower level of social attention towards individuals, albeit with a smaller effect size compared to the preferential paradigm. The results of correlations with ADOS scores indicated that the social ratio in the preferential paradigm exhibited the strongest negative correlation. Notably, there were higher effect sizes within the hrASD group in comparison to the non-ASD group when correlation with ADOS scores was tested separately for each group.
Conclusions
We have developed variables (Markov and GRI) that are robust enough to use even in the noisy eye movement recordings typical of early childhood. In the preferential paradigm, besides the AOI ratio measures, the Markov and GRI variables show promise in distinguishing ASD toddlers. Furthermore, they exhibit potential for predicting the severity level and the likelihood of autism by correlating with the ADOS score. It is conceivable that, when utilized in conjunction, these variables capture characteristics indicative of early signs of autism.
The band gap engineering with enhanced electronic, mechanical and optical responses of CsPbl3 under pressure: First-principles calculations
Authors: Babar Mehrunisa , Anwar Abdul Waheed , Moin Muhammad , Thumua Udayabhaskararao
Published: October 2023

Halide perovskite based materials have garnered substantial attention within the research community due to their numerous applications in scientific and engineering advancements. In this regard, the properties of cubic perovskite CsPbI3 have been investigated under varying hydrostatic pressures, encompassing structural, mechanical, optical, and electronic aspects. Employing density functional theory, a comprehensive analysis of CsPbI3 has been conducted, revealing its behavior under pressures ranging from 0 to 55GPa. Particularly, the computed lattice parameters and unit cell volumes exhibit significant reduction under elevated pressures. The intrinsic structure of CsPbI3 exhibits a direct band gap tuning (1.85 eV, 1.093eV, 0.93eV, 0.807eV, 0.759eV, 0.536eV and 0.350eV) at the Γ (Gamma) position at increasing external pressure (0 to 55 GPa). Remarkably, the material maintains its direct band gap characteristics under these pressures, retaining its optical activity. The alteration in bandgap arises from transformations in the density of states, impacting both the valence band maximum and the conduction band minimum. This mechanical response not only showcases the material's ductile behavior but also underscores its propensity to enhance its properties under external pressure. Moreover, the computed dielectric coefficients demonstrate a remarkable shift towards the ultraviolet (UV) range. As external pressure increases, this effect becomes more pronounced, leading to significant improvements in both optical absorption and conductivity within the CsPbI3 system. These enhancements predominantly occur within the UV range, presenting a compelling advantage for the material's potential application in solar cells.
Evolutionary patterns and heterogeneity of Dengue Virus serotypes in Pakistan
Authors: Mumtaz Zilwa , Saif Rashid , Yousaf Muhammad Zubair
Published: October 2023

Comprehensive and systematic examination of Dengue virus (DENV) evolution is essential in the context of Pakistan as the virus presents a significant public health challenge with the ability to adapt and evolve. To shed light on intricate evolutionary patterns of all four DENV serotypes, we analyzed complete genome sequences (n = 43) and envelope (E) gene sequences (n = 44) of all four DENV serotypes collected in Pakistan from 1994 to 2023 providing a holistic view of their genetic evolution. Our findings revealed that all four serotypes of DENV co-circulate in Pakistan with a close evolutionary relationship between DENV-1 and DENV-3. Genetically distinct serotypes DENV-2 and DENV-4 indicate that DENV–4 stands out as the most genetically different, while DENV-2 exhibits greater complexity due to the presence of multiple genotypes and the possibility of temporal fluctuations in genotype prevalence. Selective pressure analysis in Envelope (E) gene revealed heterogeneity among sequences (n = 44) highlighting 46 codons in the genome experiencing selective pressure, characterized by a bias towards balancing selection indicating genetic stability of the virus. Furthermore, our study suggested an intriguing evolutionary shift of DENV-4 towards the DENV-2 clade, potentially influenced by antibodies with cross-reactivity to multiple serotypes providing a critical insight into the complex factors shaping DENV evolution and contributing to the emergence of new serotype.
Rice Farmers’ Levels of Information Source on Mitigation Actions Against Climate Change Effects in North-East Zone, Nigeria
Authors: Malabe K. M. , Ango A. K.
Published: October 2023

This study assessed rice farmers’ levels of information source on mitigation actions against climate change effects in North-east zone Nigeria. Multi-stage random sampling techniques was employed to select 300 rice farmers. Data for this study were collected through primary and secondary sources. The analytical tools used in this study were descriptive (frequency count, percentages and weighted mean). The results of the socioeconomic shows that most 33% of the respondents fell within the age brackets of 47-54 with a mean age of 47.83 years. Majority 98.7% of the respondents were males, while 85.6% were married. More than half 54.7% fell within the ranges 7-11 household size. Their farming experience fell within 18-24 years with a mean farming experience of 17.15 years More than half 53.7% had no formal education. Majority (95.3) of the rice have not used mitigation actions against climate change effects. Also, level of information sources on mitigation actions and climate change effects were low and fell within the mean range of 1.0-1.70 level. Furthermore, socioeconomic characteristics significantly influence the use of mitigation actions among rice farmers. Based on the findings of this study it is concluded that majority of the rice farmers lack adequate level of information on mitigation actions and climate change effects from the sources saddle with the responsibility for providing information. Therefore, it is recommended that sources charge with the responsibility for providing information on mitigation actions and climate change effects should adequately live up to their obligations to provide farmers with useful information regarding climate related issues.
Comprehensive Pan-cancer Analysis of Cuproptosis-related Gene SLC31A1 as a Potential Biomarker for Cancer Survival and Immunotherapy
Authors: Li Huaixu , Gao Peng , Tian Haotian , Nie Jianyu , Dai Xingliang , Cheng Hongwei
Published: October 2023

Background
SLC31A1 is a cuproptosis-related gene associated with glucose metabolism in tumor cells. SLC31A1 has been linked to many different tumors in research, although no pan-cancer analysis has been conducted. This study set out to look into the connection between SLC31A1 and various malignancies.
Methods
The TCGA, GEPIA2, and cBioPortal databases were used to examine the expression of SLC31A1 and its association with prognosis in cancer. The association of SLC31A1 expression with several cancer-associated signaling pathways was further analyzed using single-cell sequencing. Finally, the functions significantly involved in SLC31A1 were investigated by immune infiltration analysis, correlation analysis of immune checkpoints, TMB and MSI, and GSEA enrichment analysis.
Results
SLC31A1 is substantially related to microsatellite instability (MSI) and tumor mutation load (TMB), indicating a positive immunotherapy response. It is also overexpressed in LGG when contrasted with standard samples. Single-cell sequencing and GSEA enrichment analysis showed that SLC31A1 is closely associated with a variety of cancer-related signaling pathways.
Conclusion
These findings serve to clarify the role of SLC31A1 in carcinogenesis from a variety of angles by showing a relationship between SLC31A1 expression and clinical outcome, DNA methylation, genetic mutations, and inflammatory cell infiltration. SLC31A1 could therefore be diagnostic for immunological and predictive aspects of many malignancies.
Survey of Compressive Sensing Techniques Based on Secure Date Aggregation in WSNs
Authors: madkour marwa , Soliman S. E. , Dessouky M. I. , El-Samie F. E. Abd , Elsafrawey A. S. , hammad M.E.
Published: October 2023

A key function of wireless sensor networks (WSN) is data collection. Due to the hot spot issue and the limited energy supply, developing data gathering techniques is complicated. The WSN faces three main challenges: security, data routing, and processing a lot of data. Since compressive sensing can achieve simultaneous sampling and compression, it is widely used in signal processing technique. Due to resource limitations and computational limitations, WSN security solutions are different from those in traditional networks. Compressive sensing (CS) and Elliptical curve Diffie-Hellman key exchange are used to solve these problems. The measurement matrix is configured to be as a public key that is understood by both the sensor node and the base station in order to achieve high safety and efficiency for data gathering in wireless sensor networks. Security and effective data collecting are the main study goals. A prime-numbered address strategy for TPID (tree path identifier) routing and cluster head selection is used. Comparison between seven types of CS algorithms is introduced over different data sparsity levels. The network parameters is being tested are Network life time, throughput, residual node energy and total energy dissipated. The results revels that the compression system can reduce the size of the transmitted data and consequently the energy consumption while still maintains the data security.
Fixed-Time Consensus of Multi-Agent System with Delayed Intermittent Control
Authors: Mwanandiye Eric S.
Published: October 2023

This paper investigates fixed-time consensus of delay multi-agent system with intermittent delay control. The delayed system is transformed into a system without delay by employing an Artstein’s reducing transformation method. The proposed nonlinear control can achieve fixed-time consensus in which upper bound settling time depends on design parameters and the time-delay. This makes it possible to determine settling time offline regardless of initial condition.
Extensive evaluation of image classifiers' interpretations
Authors: Poštić Suraja , Subašić Marko
Published: October 2023

The application of artificial intelligence in delicate fields has led to the increased popularity of deep model interpretation. When dealing with an image classification problem, interpretations are usually presented as two-dimensional saliency maps. Locations with the highest intensity are considered to be the most important for making a decision. Measuring the quality of the interpretations is challenging since humans do not understand the behavior of deep models. The biggest misconception is mistaking interpretation for weakly supervised object localization, which has reflected on the choice of the assessment metrics as well. This paper presents a carefully designed experimental procedure along with a set of quantitative interpretability assessment metrics that rely solely on the original model behavior. Previously noticed biases have been attenuated by treating locations with high and low intensity separately, considering the entire saliency maps, not just their positive values, and using classifiers with both high and low accuracy as well as all the classes in the dataset. The proposed assessment metrics were used to compare and analyze seven well-known interpretability methods on four image datasets. Even though they are ignored by some assessment metrics, our experiments show that negative saliency map values are just as important as the positive ones. DeepLIFT, Gradients X Inputs, and FullGrad achieved the best results. In contrast, Grad-CAM and Ablation-CAM have demonstrated some undesirable behaviors.
Lean Design-for-X Framework applied in the Crashworthiness and Environmental Design Assessment of a redesigned Passenger Coach
Authors: Lopes Rogério F. F. , Pinto Sara M. , Parente Marco P. L. , Moreira Pedro M. G. P. , Baptista A. J.
Published: October 2023

A comprehensive crashworthiness analysis in the design of coaches, specifically focusing on adapting the ECE R29 standard, was made. The external fiberglass composite panels of two coach models were tested for replacement with a state-of-the-art polymer (DCPD). The analysis was based on the finite element method, using the software Pamcrash®, which evaluates the energy absorption capacity of the models, comparing deformation, displacements, and material penetration values over time. The assessment of the driver's residual space, as specified by the ECE R29 standard, is also included in the analysis. The Lean Design for eXcellence (LeanDfX) methodology was used, which involves multiple domains of analysis including model optimization, manufacturing process, and eco-design. It employs an index on a 0%-100% scale, to compare different 'X' domains, such as energy absorption capacity and material intrusion. An Eco-Design X study is also conducted to assess the environmental impacts of the proposed solution compared to the original models. Quantification is carried out using the Simapro v9.2.0.2 software with the ReCiPe 2016 methodology. The modifications proposed to the coach models are shown to result in significant improvement in the structural behaviour of the vehicle for driver's physical integrity in frontal impact scenarios. The cross results of Design-for-Crashworthiness and Design-for-Eco-Design using the LeanDfX framework provide a new perspective to be integrated in the automotive industry. The use of a state-of-the-art polymer (DCPD) for the external panels, is expected to lead to a more crashworthy and environmentally friendly design for coaches, while ensuring passenger safety.
The generalized core-EP inverses involvoing projections in Banach *- algebra
Authors: Chen Huanyin , Abdolyousefi Marjan Sheibani
Published: October 2023

We investigate necessary and sufficient conditions under which the differences and products of two projections are generalized core-EP in-vertible. Then we present the representation of generalized core-EP inverse in a Banach *-algebra element by using related projections. Moreover, ex-pressions involving projections for the generalized core-EP inverse are given in a symmetric Banach *-algebra.
Efficacy of Socket Shield Technique for Immediate Implant Placement in Maxillary Anterior Region – A Case Series with Review.
Authors: Taraphdar Sreetama , Sarkar Aniket
Published: October 2023

The socket-shield technique is the most crucial treatment modality for esthetic enhancement and ridge preservation technique but it has been less discussed and documented. This case series describes the placement of implants immediately following extraction of a non-restorable which are all fractured and hopeless maxillary teeth and using this technique and functional and esthetic outcomes of the treatment was a successful event.

In this review, immediate implant were placed using socket shield protocol to treat ten patients with non-restorable teeth. Dissection was performed along the long axis of the roots in a mesiodistal direction; and atraumatically the buccal fragment of the root was left attached to the bone while the palatal fragment was extracted. Implants were placed after sequential osteotomy drilling. A customized healing abutment was fabricated chairside to create an emergence profile. During the prosthetic phase, patients had follow-up visits after 4 weeks and after 6 months. The definitive prosthesis was cemented using a cement-retained porcelain fused to metal.
Development and Institutionalization of Community Education for Climate Change Adaptation and Mitigation in Small Island Areas Based on Local Wisdom in North Tabukan, Sangihe Regency Islands
Authors: Hadianti Atrida , Heliani Leni Sophia , Nayati Widya , Kurniawan Adhy
Published: October 2023

Small islands in Indonesia are vulnerable to disasters such as earthquakes, tsunamis, floods, and landslides, one of which is the Sangihe Islands. This condition is exacerbated by climate change that is occurring and has an impact on people’s economic activities, especially in the agricultural and fisheries sectors. Climate change also affects the availability of natural resources, making them unstable and vulnerable. The activities for developing and empowering adaptation and mitigation strategies in Sangihe Islands Regency aim to overcome climate change problems through developing educational models, empowerment, community capacity, and development of the disaster task force and ProKlim. This activity uses multi-actor and multi-sector collaboration methods with a participatory and persuasive bottom-up approach adapted to local wisdom. The activity was carried out in stages: developing the E-MISI learning model, developing a policy brief, institutionalizing the disaster and ProKlim task force, increasing institutional capacity, and evaluating the learning model through FGDs. The results of the activities show that 75% - 80% of the task force already know about the impacts of climate change, adaptation, mitigation actions, and the role and resolution of the task force. The ProKlim task force’s capacity also increased by 40–50% over its last activity in 2021. It is necessary to develop education for the broader community by internalizing an educational model for climate change adaptation and mitigation into formal and informal education to achieve community resilience towards climate change in small islands.
Digital Marketing to Support the Micro, Small, and Medium Enterprises (MSME) in Tuksono Village, Sentolo, Kulonprogo, Yogyakarta
Authors: Wisnubhadra Irya , Sukartiko Anggoro Cahyo , Neisyafitri Rendayu Jonda , Jumeri
Published: October 2023

The poverty rate in Indonesia is still at 7.60% or equivalent to 26.50 million people, which is still relatively high as of September 2021—women are the vulnerable subgroup among the impoverished and are often inevitably stigmatized. On the contrary, women’s tenacity to face an economic crisis following their capacity to sustain the household economy is an ineluctable fact. This is proven by the productive business ventures that have survived the economic crisis, founded and managed by Indonesian women. Household economic resilience may significantly impact a community's economic resilience. Thus, women in households’ empowerment in the economic realm are notably crucial. Looking for the best strategies to strengthen households’ economic resilience and upgrade the ability to compete in an intense economic rivalry becomes urgent. Micro, Small, and Medium Enterprises (MSME) empowerment is one of the most efficient ways to develop a community. Tuksono Village is one of the villages with a high poverty rate in Kulon Progo, Yogyakarta. Yet, based on early observations, several MSMEs exist in Tuksono Village, although Covid-19 has severely impacted most since early March 2020. Based on the latest MSME situation in Tuksono Village, The analysis indicates that various issues must be addressed immediately. Some problems were that most MSMEs are not currently competitive, unstable offline marketing progress due to the pandemic, and the absence of indicators to measure the effectiveness of household economy’s products marketing. This activity aims to design an information system and digital marketing platform for MSME products in Tuksono Village.
Diversification of Used Cooking Oil into Biodiesel as an Attempt to Increase BumDes Mangesti Sejahtera’s Revenue in Gentan Village, Baki District, Sukoharjo Regency
Authors: Wijaya Karna , Trisunaryanti Wega , Tahir Iqmal , Yuwono Nasih Widya , Haryono Didik , Fransiska Uke , Daryanto Eko , Fatwa Mumu Mujahid , Ningrum Tyas Sekar , Mahmudah Rizqi , Agharadatu Raditya Hanandika
Published: October 2023

One of the types of waste produced by the Gentan community is used cooking oil. Previously, the people and the business actors in Gentan reused it in their daily activities. However, they acknowledge that it may damage food nutrition and even cause cancers for its fatty acids. In response to such problems, the Regency Government worked jointly to construct a waste recycling technology called TPS3R. In 2021, the head of Gentan stated that they had started an activity called GELIMPAH (Gentan Peduli Sampah, the community’s action of concern towards waste) program by collecting wastes from households and converting those into gold savings under the waste-to-gold program supported by PT Pegadaian. BUMDes (Badan Usaha Milik Desa or Village-Owned Enterprise) also collected used cooking oil from residents and business units as much as 30-50 m3 per week—even collected 70 m3 in the last week of March 4th, 2022. The collected oil was expected to be appropriately processed and economically valuable for the community. Together with the head of Gentan, the team worked in diversifying used cooking oil to become a biodiesel fuel. This activity was expected to be a parameter or benchmark for the collaboration’s fruitfulness regarding constructing a biodiesel development zone from used cooking oil. Furthermore, it was also expected that there would be the re-establishment of the used cooking oil processing technology into biodiesel (using biodiesel refinery technology) by building a biodiesel reactor with 100 L capacity. This application aimed to develop Gentan as a biodiesel or bio-energy development zone in Sukoharjo, as it produces a reactor as a technological handover from the university to the community, along with establishing cooperation between universities, other higher education institutions, and the community or BUMDes. This appropriate technology’s implementation has resulted in a reactor for processing used cooking oil into biodiesel with the characteristics according to SNI-2015.
Dissemination of SDGs 4, 9, 13 through Strengthening Curriculum for Senior Vocational High Schools
Authors: Khuriyati Nafis , Guritno Adi Djoko , Kurniawan Muhammad Prasetya , Hidayah Nurulia , Hendry Jans
Published: October 2023

Education for Sustainable Development (ESD) plays a vital role in achieving the 17 Sustainable Development Goals (SDGs) and simultaneously addressing today's global challenges. The development of ESD in Senior Vocational High Schools (SMK) provides opportunities for teachers and students to contribute to achieving these goals. SMKN 1 Nanggulan was chosen as this study's object as it promotes a program and curriculum that aligns with Kulonprogo's necessity to prepare future leaders with technological and agricultural-based expertise. To obtain further information as a sharpening strategy for SDGs (4,9,13) diffusion strategies in SMKN 1 Nanggulan, data collection methods were carried out: (1) surveys; (2) in-depth interviews with the teachers and students; and (3) Focus Group Discussion (FGD) with teachers, groups of farmers, Fablab UGM, and policy implementers (Department of Education). Purposive sampling (non-probability sampling) was conducted to identify learning outcomes for 97 students who took IPAS (Ilmu Pengetahuan Alam dan Sosial, Natural, and Social Science course) about sources of information on SDGs. Three main activities have been communicated and evaluated with the teachers of SMKN 1 Nanggulan to sharpen and diffuse learning resources and increase awareness to implement the SDGs, especially regarding quality education (SDG 4), innovation for creative industries (SDG 9), and climate change mitigation (SDG 13). In addition, implementing digital literacy usage and supervision for media learning must be improved to enhance learning outcomes.
The Implementation of Occupational Health Safety (OHS) Activities Reporting Web-Based System in Community Public Health Centre at Yogyakarta City Health Office
Authors: Askar Nia Fararid , Herawati Dian , Pratomo Dinar Nugroho , Susilawati  , Khasanah Uswatun
Published: October 2023

One of the activities that must be carried out as a part of the Occupational Health Safety (OHS) management system is recording and reporting at health facilities. As information technology is growing rapidly, a system is needed to assist in the recording and reporting of OHS activities process on health facilities. e-SIMKAGA is a web-based information and management system that can assist health facilities (especially public health centers) to record and report OHS activities more effectively and efficiently. This activity aims to implement OHS Activities Reporting Smart System Based to optimize OHS culture’s application in realizing zero accident cases at Yogyakarta’s public health centers. These activities follow the stages of the System Development Life Cycle (SDLC). The target group is 18 members of Upaya Kesehatan Kerja Puskesmas (UKK Puskesmas, an Occupational Health Unit’s group of Person in Charge (PIC) in the Public Health Center) in Yogyakarta. The activities started in April to October 2022, which concluded system development, socialization, training on the e-SIMKAGA usage, and user acceptance evaluation to determine the ease of use, usefulness, and behavior of the system’s continuity. This research resulted in the statement of e-SIMKAGA users that they were satisfied with the ease of use and usefulness and were willing to continue using e-SIMKAGA as a web-based Information System and Reporting Management of OHS activities at health facilities.
Development of Marketing Channels and Packaging Innovation on “JOSS” Organic Rice to Increase Added Value
Authors: Kristanti Novita Erma , Khuriyati Nafis , Winarno Agustinus , Pradita Sintia Putri
Published: October 2023

The development of organic farming in Jatisarono Village, Kapanewon Nanggulan, Kulon Progo, Yogyakarta is being carried out by three groups of farmers with 150 members. Organic rice is a superior commodity under the JOSS brand (Jatisarono Organik Sehat Sejahtera). JOSS organic rice product is registered as an organic certificate institution with the number 390-LSO-005-IDN-11-20. Problems regarding marketing channels and packaging still need to be solved. Market access capability for selling organic rice still needs to be improved. At the same time, the packaging used is still simple and has yet to consider more detailed packaging aspects. This community service aims to conduct education on developing marketing channels and JOSS organic rice packaging innovation. The education carried out involves basic research, so the recommendations are expected to improve the economy of farmer groups and the community in Jatisarono Village. The method used in community service activities is an integrated approach consisting of farmer groups, JOSS organic rice business activities, and university participation. The development of marketing channels is implemented based on supply chain adequacy and market behavior based on price levels. Product development is applied to create packaging innovation designs. The activities carried out were socialization regarding marketing channels and rice packaging to farmer groups, focus group discussions with experts on determining target markets and packaging innovation designs, workshops on various packaging design alternatives, and delivery of results regarding alternatives to other marketing access and packaging design results. The outputs of this community activity are the development of markets and marketing channels which have been carried out in two stages in cooperatives and minimarkets around Universitas Gadjah Mada, and three designs of organic rice packaging based on consumer suggestions and following mandatory packaging aspects on rice according to Minister of Trade Regulation No. 8 of 2019.
Innovation Development of Desapolitan ASTP Jimbung-Bayat Purba
Authors: Suratman  , Fatimah Rika , Nugroho Andhika Puspito
Published: October 2023

Bayat District has a vast potential for development if supported by adequate resources. The potential that can be developed is mainly related to tourism with the Desapolitan Agro Science Techno Park (ASTP) concept. Jimbung Village, located in the Krakitan District, is the focus area for assisted village activities. In general, this assisted village activity aims to implement, develop and innovate community empowerment in realizing self-sufficiency and community welfare based on innovation in developing community potential so that it can develop and optimize resources. The approach in community empowerment activities is adopted from various empowerment concepts such as Focus Group Discussion (FGD), Quadruple Helix Model, and G2R Tetrapreneur Model. Performance assessment indicators were set from Identification of Potential and Problems of Desapolitan, FGD, training and mentoring, observation and identification, evaluation, and introduction of Agro Science Techno Park Desapolitan Jimbung.
Keynote Talk: Sustainability for All - The ‘Whole of Humanity’ Approach
Authors: bin Abdul Razak Tan Sri Dato' Dzulkifli
Published: October 2023

Sustainability has been defined in the Brundtland Report as: "Development that meets the needs of the present without compromising the ability of future generations to meet their own needs" (1987). While this is readily accepted by many to date, it raises several questions about where the "past" belongs. This is a crucial reflection in trying to realign with the above approach, namely with respect to socio-cultural and spiritual perspectives. The former is to allow the traditional and indigenous concepts to be embraced more "naturally" within the diverse cultural contexts, whereas the latter is to enable each of the socio-cultural context be connected in more holistic ways as part of the shared human heritage. Cumulatively, it forms a continuum framework with a deeper understanding of "sustainability" as a living journey since time immemorial for better quality of life encompassing humanity as a whole. That is, the "whole of humanity" approach. The presentation will argue how this can be done for a wider and more comprehensive application of sustainability for all.
Determinants of Customer Loyalty: Empirical Study from Online Food Delivery Services
Authors: Louisa Laeticia , Simbolon Freddy Pandapotan
Published: October 2023

The rapid growth of information technology and communication today has disrupted various sectors, including the food sector. Consumers’ behavior in ordering food has shifted from offline to online with the presence of a number of food delivery service applications. This situation encourages the growth of online applications that provide food delivery services, so intense competition is unavoidable. The research aimed to investigate the role of e-service quality and sales promotion in influencing customer e-trust and e-satisfaction and its implications for customer loyalty. The research used a quantitative approach with the survey method. The population was online food delivery service application users who lived in the Jakarta area, with a sample of 250 respondents. The data were collected through a questionnaire designed with a 5-point Likert scale and analyzed using SEM-PLS. Research findings show that customer e-service quality and sales promotion significantly influence customers’ e-trust and e-satisfaction. Other findings show that customers’ e-trust and e-satisfaction significantly affect customer loyalty. The results also indicate that customers’ e-trust and e-satisfaction significantly mediate the effect of e-service quality and sales promotion on customer loyalty. In the era of the digital economy, good service and effective promotion still have an important role in increasing trust and satisfaction and a positive impact on increasing consumer loyalty ultimately.
The effectiveness of a new antiviral drug of plant origin in the form of eye drops in the complex therapy of ophthalmic herpes
Authors: Yani E. V. , Kamenskikh T. G. , Veselova E. V. , Zubkova T. G. , Stovbun S. V. , Seliverstova K. E. , Pozdnyakova V. V. , Stupakova M. M.
Published: October 2023

Ophthalmic herpes is the most common infection-related cause of blindness in developing countries.Purpose: to evaluate the therapeutic efficacy, safety and tolerability of the drug Panavir® used as part of a combination therapy for herpetic superficial dendritic keratitis.Materials and methods. The study involved 106 patients aged 18 to 65 years divided into two groups. Group 1 (54 patients; 54 eyes) received treatment with Panavir® and Acyclovir ophthalmic ointment, whilst Group 2 (52 patients; 52 eyes) received a placebo of Panavir® and Acyclovir ophthalmic ointment. The primary parameter of the efficiency was the percentage of patients achieving clinical recovery, i.e. signs of complete epithelialization of the cornea.Results. In group 2 (monotherapy), a significantly greater number of patients with mild conjunctival hyperemia was registered than in the combination therapy group 1 — 59.26 vs. 23.08 %, p < 0.001. In group 1, the proportion of patients without corneal syndrome at visits 3 and 4 was, respectively, 11.11 and 61.11 %, while in group 2 it was only 3.85 and 19.61 %, respectively.Conclusion. The drug Panavir® eye drops 0.004 % showed a high therapeutic efficiency in the combined treatment of herpetic keratitis, and good tolerance. It also reduced the time required for corneal epithelialization and conjunctiva normalization.
Telemedicine for glaucoma: the state-of-the-art and trends of development
Authors: Petrov S. Yu. , Malishevskaya T. N. , Farikova E. E. , Markelova O. I.
Published: October 2023

Glaucoma is the top leading cause of ophthalmic-related disability in almost all Russian regions. It is a chronic lifelong disease which requires regular monitoring (once a year or more often) in a medical facility. Since the population is aging, the prevalence of glaucoma is steadily increasing, which hampers access to medical care. Advances in telecommunications and diagnostic technologies have given rise to programs of TV glaucoma, which are used to pass the basic glaucoma parameters on to a specialist working remotely for interpretation. The Federal Law No 242-FZ on telemedicine came into force on January 1, 2018, but the COVID-19 pandemic sped up the development of information technologies in medicine in general and telemedicine communication in particular. The review presents the data on TV glaucoma programs which point to their effectiveness and provides practical advice. Potentially, telemedicine can facilitate access to medical care. The analysis of the economic factors shows that remote consulting is more cost-effective than traditional face-to-face examination of the patient. TV glaucoma programs often help detect glaucomatous changes in the ONH, so more patients with suspicion of glaucoma are referred for screening.. Publications focused on the experience in using active programs contribute to their further development and introduction to the public health system, which will eventually facilitate the access to quality medical care for patients with glaucoma.
Prediction of late results of surgical treatment of traumatic retina detachment in eye injury of multiple origin
Authors: Leparskaya N. L.
Published: October 2023

Purpose. To evaluate the possibility of predicting the anatomical and functional results of surgical treatment of traumatic retinal detachment (RD) in trauma of various geneses, taking into account the clinical picture and the severity of the proliferative syndrome based on large clinical data.Materials and methods. A comprehensive analysis of the clinical picture (using 22 features) and long-term results of surgical treatment of 427 patients with traction traumatic RD (TRD) after open and closed eye injury was carried out. The patients were divided into 7 groups depending on the mechanism of injury. The observation period was 5 years.Results. The most severe proliferative syndrome was observed in TRD after an open injury: OEI A (contusions with scleral rupture), OEI D (double puncture wound) and OEI E (explosive trauma with scleral rupture), when both the process of mooring and PVR are present, as well as with CEI A (contusion) in the event that after the first operation PVR continued to progress. We found a direct dependence of PVR activity in TRD on the area of the detached retina and the presence of a traumatic cataract, and the inverse dependence on the presence of intraocular foreign body (IFB), its size and the ability of IFB to cause metallosis. A direct dependence of long-term functional results of treatment on the PVR stage, the area of detached retina and the diagnosed retinal rupture during the first vitreoretinal surgical intervention was established.Conclusion. In order to make the surgical treatment of TRD more effective, it is worth using antiproliferative drugs intravitreally during vitreoretinal surgery, especially in OEI A, OEI D and OGI E, when the proliferative syndrome is caused both by PVR and mooring, as well as in CEI A in the case of a pronounced PVR stage.
Measuring Customer Purchasing Behavior based on Apriori Algorithm for Creating an Efficient Marketing Strategy
Authors: AKCIL Murat , AKCAN Serap
Published: October 2023

Due to technological developments and competitive conditions, it is becoming more and more important to gain customers and keep them. Association rules are one of the methods used effectively to determine which products and services are more important and preferred by customers together. The aim of this study is to determine the types of patterns purchased by a company operating in the forest products sector, using the data of decor paper, which affects the cost the most, is used extensively in production and is difficult to plan. This study was carried out with the Apriori algorithm in WEKA, which is widely used in association analysis. It is thought that the association rules obtained from this study will enable the firm to determine the purchasing behaviors of its customers by revealing the overseas model trends and associations. In addition, this study will shed light on the company at the stage of determining the marketing strategy of the company.
Adana İli İçme Suyu Kalite İndeksinin Belirlenmesi
Authors: GÜLOGLU Ebubekir , BAŞIBÜYÜK Mesut , BALCI Behzat , ERKURT Fatma Elçin
Published: October 2023

Su kalite indeksleri son yıllarda su kalitesini değerlendirmek için kullanılan önemli bir yöntemdir. Temel mantığı pek çok parametre içeren su kalitesinin basit bir sayı halinde ifade edilmesi temeline dayanır. Tüm Dünyada su kalitesinin değerlendirilmesinde son derece önemli bir kriterdir. Benzer bir çalışma da Adana ili içme suyu temin edilen kaynaklara yönelik olarak gerçekleştirilmiştir. Adana ili su kalitesi (Seyhan, Yüreğir, Sarıçam, Çukurova) içme suyu kalite indeksi iki metod ve on beş su kalite parametresi pH, elektriksel iletkenlik (EC), bulanıklık, tuzluluk, toplam çözünmüş katı madde (TDS), çözünmüş oksijen, klorür (Cl), nitrat (NO3), sülfat (SO4), fosfat (PO4), demir (Fe), alüminyum (Al), sodyum (Na), kalsiyum (Ca), magnezyum (Mg) kullanılarak belirlenmiştir. Elde edilen sonuca göre Kanada su kalite indeksi 84,6, British Columbia su kalite indeksi 81,6 olarak hesaplanmıştır. Bu çalışma, Adana ilinde içme suyu kalite sınıfının iyi olduğunu göstermiştir.
Synthesis of Tetrahydrobenzo[b]pyrans Catalyzed by 1,3-Dibenzyl-1H-benzo[d]
imidazole-3-ium Chloride
Authors: Delfani Ali Moradi , Kiyani Hamzeh , Zamani Mehdi
Published: October 2023

Tetrahydrobenzo[b]pyrans are fused oxygen-containing heterocycles that are found in many biologically
active compounds. Therefore, researchers in organic synthesis are searching for suitable, efficient, and
useful methods for their synthesis. In this contribution, a series of tetrahydrobenzo[b]pyran derivatives was synthesized
using aryl aldehydes, malononitrile, and cyclohexane-1,3-dione or dimedone as the available starting
materials. The three-component reactions were catalyzed by 1,3-dibenzyl-1H-benzo[d]imidazol-3-ium chloride
as the N-heterocyclic carbene precursor. The heterocyclic oxygen-containing products were obtained in good to
excellent isolated yields within relatively shorter reaction times. Optimizing the reaction conditions was performed
from the point of view of various parameters of the reaction. The results of these experiments showed
that the best solvent system includes water-ethanol, the most suitable reaction temperature is 60ºC, and the optimal
amount of the imidazolium catalyst loading is 5 mol%. Operational simplicity, no need for chromatographic
methods for purification, simple work-up for pure products, and avoiding hazardous solvents are remarkable
features of this three-component reaction. Moreover, in these multicomponent cyclo-condensations,
no by-products were observed.
Optimizing the Extraction of Polyphenols from the Bark of Terminalia arjuna and an In-silico Investigation on its Activity in Colorectal Cancer
Authors: Adhikary Tathagata , Basak Piyali
Published: October 2023

Background:

The interconnection between different fields of research has gained interest
due to its cutting-edge perspectives in solving scientific problems. Terminalia arjuna is indigenously
used in India for curing several diseases, and its pharmacological activities are being
revisited in recent drug-repurposing research.

Objective:

Efficient ultrasound-assisted extraction of phytochemicals from the bark of Terminalia
arjuna is highlighted in this study. Following the optimization of the extraction process, the
crude hydroethanolic extract is subjected to phytochemical profiling and an in-silico investigation
of its anti-cancer properties.

Materials and Methods:

A three-level four-factor Box-Behnken design is exploited to optimize
four operational parameters, namely extraction time, ultrasonic power, ethanol concentration (as
the extracting solvent) and solute (in g): solvent (in mL) ratio. At the optimum parametric condition,
the crude extract is obtained, and its GC-MS analysis is carried out. An analysis of network
pharmacology (by constructing and visualizing biological networks using Cytoscape) combined
with molecular docking reveals the potential antineoplastic targets of the crude extract.

Results:

The ANOVA table exhibits the significance, adequacy and reliability of the proposed
second-order polynomial model with the R² value of 0.917 and adjusted R² of 0.865. Experimental
results portray the significant antioxidant potential of the prepared extract in its crude
form. The GC-MS analysis of the crude extract predicts the extracted phytochemicals, while the
constructed biological networks highlight its multi-targeted activity in colorectal cancer

Conclusion:

The study identifies three phytochemicals viz. luteolin, β-sitosterol and arjunic acid
as potent anti-cancer agents and can be extended with in-vitro and in-vivo experiments to validate
the in-silico results, thus establishing lead phytochemicals in multi-targeted colorectal cancer
therapies.