bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on multi-person collaborative design of BIM drawing based on blockchain
Authors: Wang Jinlong , Shen Yumin , Xiong Xiaoyun , Wang Xu , Fang Xiaoxue
Published: September 2022

The existing multi-person collaborative design scheme of Building Information Modeling (BIM) integrated with blockchain faces problems such as poor reliability of BIM drawing, inconsistent drawing information, redundant information, and inaccurate protection of copyright interests. This paper proposes a multi-person collaborative design model for BIM drawing that combines blockchain and InterPlanetary File System (IPFS). This model uses blockchain to store drawing design information to protect the copyright interests of designers and combines IPFS to ensure the reliability of drawing. A cycle division mechanism is designed to solve the problem of drawing information synchronization when multiple people collaborate in design. The Semantic Differential Transaction (SDT) method is used to achieve incremental update of drawing and reduce the information redundancy of the blockchain. Finally, a comparative analysis and validation evaluation of the scheme is carried out, and the usability of the scheme is illustrated with an illustrative example. The results show that: (1) proposed scheme is feasible for multi-person collaborative design; (2) proposed scheme can effectively ensure the reliability of drawing and reduce the redundancy of blockchain information, so as to achieve copyright protection for designers.
Technological and functional analysis of 80–60 ka bone wedges from Sibudu (KwaZulu-Natal, South Africa)
Authors: d’Errico Francesco , Backwell Lucinda R. , Wadley Lyn , Geis Lila , Queffelec Alain , Banks William E. , Doyon Luc
Published: September 2022

Fully shaped, morphologically standardized bone tools are generally considered reliable indicators of the emergence of modern behavior. We report the discovery of 23 double-beveled bone tools from ~ 80,000–60,000-year-old archaeological layers at Sibudu Cave in KwaZulu-Natal, South Africa. We analyzed the texture of use-wear on the archaeological bone tools, and on bone tool replicas experimentally used in debarking trees, processing rabbit pelts with and without an ochre compound, digging in sediment in and outside a cave, and on ethnographic artefacts. Debarking trees and digging in humus-rich soil produce use-wear patterns closely matching those observed on most Sibudu tools. This tool type is associated with three different Middle Stone Age cultural traditions at Sibudu that span 20,000 years, yet they are absent at contemporaneous sites. Our results support a scenario in which some southern African early modern human groups developed and locally maintained specific, highly standardized cultural traits while sharing others at a sub-continental scale. We demonstrate that technological and texture analyses are effective means by which to infer past behaviors and assess the significance of prehistoric cultural innovations.
Development of individual identification method using thoracic vertebral features as biometric fingerprints
Authors: Sato Mitsuru , Kondo Yohan , Okamoto Masashi , Takahashi Naoya
Published: September 2022

Identification of individuals is performed when a corpse is found after a natural disaster, incident, or accident. DNA and dental records are frequently used as biometric fingerprints; however, identification may be difficult in some cases due to decomposition or damage to the corpse. The present study aimed to develop an individual identification method using thoracic vertebral features as a biological fingerprint. In this method, the shortest diameter in height, width, and depth of the thoracic vertebrae in the postmortem image and a control antemortem were recorded and a database was compiled using this information. The Euclidean distance or the modified Hausdorff distance was calculated as the distance between two points on the three-dimensional feature space of these measurement data. The thoracic vertebrae T1-12 were measured and the pair with the smallest distance was considered to be from the same person. The accuracy of this method for identifying individuals was evaluated by matching images of 82 cases from a total of 702 antemortem images and showed a hit ratio of 100%. Therefore, this method may be used to identify individuals with high accuracy.
Differentiating a pachychoroid and healthy choroid using an unsupervised machine learning approach
Authors: Mirshahi Reza , Naseripour Masood , Shojaei Ahmad , Heirani Mohsen , Alemzadeh Sayyed Amirpooya , Moodi Farzan , Anvari Pasha , Falavarjani Khalil Ghasemi
Published: September 2022

The purpose of this study was to introduce a new machine learning approach for differentiation of a pachychoroid from a healthy choroid based on enhanced depth-optical coherence tomography (EDI-OCT) imaging. This study included EDI-OCT images of 103 eyes from 82 patients with central serous chorioretinopathy or pachychoroid pigment epitheliopathy, and 103 eyes from 103 age- and sex-matched healthy subjects. Choroidal features including choroidal thickness (CT), choroidal area (CA), Haller layer thickness (HT), Sattler-choriocapillaris thickness (SCT), and the choroidal vascular index (CVI) were extracted. The Haller ratio (HR) was obtained by dividing HT by CT. Multivariate TwoStep cluster analysis was performed with a preset number of two clusters based on a combination of different choroidal features. Clinical criteria were developed based on the results of the cluster analysis, and two independent skilled retina specialists graded a separate testing dataset based on the new clinical criteria. TwoStep cluster analysis achieved a sensitivity of 1.000 (95-CI: 0.938–1.000) and a specificity of 0.986 (95-CI: 0.919–1.000) in the differentiation of pachy- and healthy choroid. The best result for identification of pachychoroid was obtained for a combination of CT, HR, and CVI, with a correct classification rate of 0.993 (95-CI: 0.980–1.000). Based on the relative variable importance (RVI), the cluster analysis prioritized the choroidal features as follows: HR (RVI: 1.0), CVI (RVI: 0.87), CT (RVI: 0.70), CA (RVI: 0.59), and SCT (RVI: 0.27). After performing a receiver operating characteristic curve analysis on the cluster membership variable, a cutoff point of 389 µm and 0.79 was determined for CT and HR, respectively. Based on these clinical criteria, a sensitivity of 0.793 (95-CI: 0.611–0.904) and a specificity of 0.786 (95-CI: 0.600–0.900) and 0.821 (95-CI: 0.638–0.924) were achieved for each grader. Cohen's kappa of inter-rater reliability was 0.895. Based on an unsupervised machine learning approach, a combination of the Haller ratio and choroidal thickness is the most valuable factor in the differentiation of pachy- and healthy choroids in a clinical setting.
Development of a new scoring method in the neurofunctional assessment of preterm infants
Authors: Picciolini Odoardo , Giannì Maria Lorella , Messina Laura , Pesenti Nicola , Fumagalli Monica , Gardon Laura , Squarza Chiara , Mosca Fabio , Fontana Camilla , Porro Matteo
Published: September 2022

Infants born preterm are at high risk of presenting neurodevelopmental delay. The Neurofunctional Assessment (NFA) describes infants’ neurodevelopment through the evaluation of six different domains. This study aimed to evaluate how, in a cohort of preterm infants, each NFA domain assessed at 3 months of corrected age (CA) was associated with neurodevelopment at 2 years of CA using the Griffiths Mental Developmental Scales Extended Revised (GMDS-ER). In addition, by introducing the NFA complexity score (CS), the study aimed to define a threshold that can help clinicians discriminate infants at higher risk of later neurodevelopmental delay. We conducted an observational, longitudinal study including 211 preterm infants. At 3 months of CA, infants who had normal scores in each domain showed a significantly higher GMDS-ER global quotient (GQ) at 2 years of CA. In addition, linear model results showed a significant negative relationship between the NFA CS and 2-year GMDS-ER GQ (estimate: − 0.27; 95% CI − 0.35, − 0.20; p value < 0.001). Each 10-point increase in the NFA CS was associated with an average 2.7-point decrease in the GMDS GQ. These results highlight how the NFA domains and NFA CS are compelling instruments for the early identification of children at risk for long-term adverse outcomes.
Elevated G-CSF, IL8, and HGF in patients with definite Meniere’s disease may indicate the role of NET formation in triggering autoimmunity and autoinflammation
Authors: Zou Jing , Zhao Zikai , Song Xianmin , Zhang Guoping , Li Hongbin , Zhang Qing , Pyykkö Ilmari
Published: September 2022

The etiology and mechanism causing Meniere’s disease (MD) are not understood. The present study investigated the possible molecular mechanism of autoimmunity and autoinflammation associated with MD. Thirty-eight patients with definite MD and 39 normal volunteers were recruited, and 48 human cytokines/chemokines were quantified. In patients with MD pure tone audiograms, tympanograms and standard blood tests were performed. The mean hearing loss in the worse ear was 44.1 dB nHL. Compared to the referents, the concentrations of TNFα, IL1α, IL8, CTACK, MIP1α, MIP1β, G-CSF, and HGF in the sera of patients with MD were significantly elevated, while those of TRAIL and PDGFBB were significantly decreased. The area under the receiver operating characteristic curve (AUC) showed that G-CSF, MIP1α, and IL8 were above 0.8 and could be used to diagnose MD (p < 0.01), and the AUCs of CTACK and HGF were above 0.7 and acceptable to discriminate the MD group from the control group (p < 0.01). The revised AUCs (1 − AUC) of TRAIL and PDGFBB were above 0.7 and could also be used in the diagnosis of MD (p < 0.01). The linear regression showed significant correlations between MIP1α and GCSF, between IL2Rα and GCSF, between IL8 and HGF, between MIP1α and IL8, and between SCF and CTACK; there was a marginal linear association between IP10 and MIP1α. Linear regression also showed that there were significant age-related correlations of CTACK and MIG expression in the MD group (p < 0.01, ANOVA) but not in the control group. We hypothesize that G-CSF, IL8, and HGF, which are involved in the development of neutrophil extracellular traps (NETs) and through various mechanisms influence the functions of macrophages, lymphocytes, and dendritic cells, among others, are key players in the development of EH and MD and could be useful in elucidating the pathophysiological mechanisms leading to MD. Biomarkers identified in the present study may suggest that both autoimmune and autoinflammatory mechanisms are involved in MD. In the future, it will be valuable to develop a cost-effective method to detect G-CSF, IL8, HGF, CTACK, MIP1α, TRAIL, and PDGFBB in the serum of patient that have diagnostic relevance.
A tuff interlayer in deep potash-bearing salt rocks and its implication for potash mineralization in the Simao Basin, southwestern China
Authors: Miao Zhong-Ying , Zheng Mian-Ping , Lou Peng-Cheng , Wang Dong , Xu Qi-Hui , Xu Jian-Ming
Published: September 2022

The lithology and genesis of a dark grey clastic interlayer first encountered within the deepest potassium-rich salt body in the Simao Basin, southwestern China, were analysed. Analyses of the petrography, mineralogy, and element geochemistry of the layer revealed that (1) the layer contains quartz crystals with gulf corrosion edges and explosion cracks and angular volcanic ash-sized glasses; (2) the main mineral components of the crystal fragments are chlorite, illite, biotite, quartz, anhydrite, gypsum, magnesite, pyrite, molybdenite, clinopyroxene, and zircon; (3) the rare earth element patterns, Zr/TiO2 and Nb/Y diagrams as well as boron content all indicate a volcanic origin for the layer. Based on these observations, the layer is suggested to be an altered tuff associated with various volcanic fragments dominated by chlorite and formed after alteration of a parent tuff in an alkaline, salty, and low-temperature water body. Discovery of the layer indicates that the potash-bearing salt rocks could have taken in volcanic materials during these volcanic activities and provides the possibility of reliable zircon U‒Pb dating to determine the absolute age of the host rock, which is fundamental in studying the genetic mechanism of this deeply buried salt body.
Silicon as a potential limiting factor for phosphorus availability in paddy soils
Authors: Schaller Jörg , Wu Bei , Amelung Wulf , Hu Zhengyi , Stein Mathias , Lehndorff Eva , Obst Martin
Published: September 2022

Rice cultivation requires high amounts of phosphorus (P). However, significant amounts of P fertilizer additions may be retained by iron (Fe) oxides and are thus unavailable for plants. At the same time, rice cultivation has a high demand for silicic acid (Si), reducing Si availability after short duration of rice cultivation. By studying a paddy chronosequence with rice cultivation up to 2000 years, we show that Si limitation, observed as early as a few decades of rice cultivation, is limiting P availability along the paddy soils chronosequence. Using near edge X-ray absorption fine structure spectroscopy (NEXAFS) in a scanning transmission (soft) X-ray microscope (STXM) we show release of available P was linked to a Si-induced change in speciation of Fe-phases in soil particles and competition of Si with P for binding sites. Hence, low Si availability is limiting P availability in paddy soils. We propose that proper management of Si availability is a promising tool to improve the P supply of paddy plants.
Domain-specific hearing-in-noise performance is associated with absolute pitch proficiency
Authors: Hsieh I-Hui , Tseng Hung-Chen , Liu Jia-Wei
Published: September 2022

Recent evidence suggests that musicians may have an advantage over non-musicians in perceiving speech against noisy backgrounds. Previously, musicians have been compared as a homogenous group, despite demonstrated heterogeneity, which may contribute to discrepancies between studies. Here, we investigated whether “quasi”-absolute pitch (AP) proficiency, viewed as a general trait that varies across a spectrum, accounts for the musician advantage in hearing-in-noise (HIN) performance, irrespective of whether the streams are speech or musical sounds. A cohort of 12 non-musicians and 42 trained musicians stratified into high, medium, or low AP proficiency identified speech or melody targets masked in noise (speech-shaped, multi-talker, and multi-music) under four signal-to-noise ratios (0, − 3, − 6, and − 9 dB). Cognitive abilities associated with HIN benefits, including auditory working memory and use of visuo-spatial cues, were assessed. AP proficiency was verified against pitch adjustment and relative pitch tasks. We found a domain-specific effect on HIN perception: quasi-AP abilities were related to improved perception of melody but not speech targets in noise. The quasi-AP advantage extended to tonal working memory and the use of spatial cues, but only during melodic stream segregation. Overall, the results do not support the putative musician advantage in speech-in-noise perception, but suggest a quasi-AP advantage in perceiving music under noisy environments.
Optical coherence tomography findings after surgery for sub-inner limiting membrane hemorrhage due to ruptured retinal arterial macroaneurysm
Authors: Hayamizu Ryosuke , Totsuka Kiyohito , Azuma Kunihiro , Sugimoto Koichiro , Toyama Taku , Araki Fumiyuki , Shiraya Tomoyasu , Ueta Takashi
Published: September 2022

Ruptured retinal arterial macroaneurysm (RAM) can cause sub-inner limiting membrane (ILM) hemorrhage, leading to acute vision loss in the elderly. Vitrectomy has been established as an effective treatment to remove hemorrhage and facilitate visual recovery. Although optical coherence tomography (OCT) is useful for the diagnosis of sub-ILM hemorrhage before surgery, little is known about the postoperative OCT findings. Here, we retrospectively investigated the records of nine eyes of nine patients who underwent surgery for sub-ILM hemorrhage due to RAM rupture. On postoperative OCT, hyperreflectivity throughout the full thickness of the central fovea was observed in eight eyes (88.9%), and disruption of the ellipsoid/interdigitation zone (EZ/IZ) was observed in seven out of eight eyes (87.5%). The widths of the hyperreflectivity and EZ disruption gradually decreased. Visual recovery was least favorable in two eyes, in which the EZ line continuation did not recover until the final follow-up. The OCT findings corresponded to the hemorrhagic staining identified on fundus photographs in at least four eyes; as per the fundus photographs the findings persisted even after the hemorrhage was absorbed. In contrast, the OCT findings resembled the appearance before the development of a full-thickness macular hole, suggesting fragility caused by the RAM rupture.
Ethics, law, and politics in palaeontological research: The case of Myanmar amber
Authors: Dunne Emma M. , Raja Nussaïbah B. , Stewens Paul P. , Zin-Maung-Maung-Thein  , Zaw Khin
Published: September 2022

Fossil material in amber from Myanmar can provide important insights into mid-Cretaceous forest ecosystems. However, Myanmar amber has been receiving increased international attention due to reported links between amber mining and the ongoing humanitarian crisis in northern Myanmar, as well as the legal issues associated with its exportation. Here, we conduct a bibliometric analysis of Myanmar amber publications (1990–2021) and demonstrate how research interest in Myanmar amber is explicitly linked to major political, legal, and economic changes. An analysis of the authorship networks for publications on amber inclusions reveals how current research practices have excluded Myanmar researchers from the field. In addition, the international trade of Myanmar amber with fossil inclusions falls into a legal ‘grey-zone’ which continues to be exploited. This case study vividly demonstrates that systemic changes, alongside an increased awareness of inequitable research practices amongst the broader scientific and allied communities, are urgently needed to curb illegal practices in palaeontology.
The VersaLive platform enables microfluidic mammalian cell culture for versatile applications
Authors: Nocera Giovanni Marco , Viscido Gaetano , Criscuolo Stefania , Brillante Simona , Carbone Fabrizia , Staiano Leopoldo , Carrella Sabrina , di Bernardo Diego
Published: September 2022

Microfluidic-based cell culture allows for precise spatio-temporal regulation of microenvironment, live cell imaging and better recapitulation of physiological conditions, while minimizing reagents’ consumption. Despite their usefulness, most microfluidic systems are designed with one specific application in mind and usually require specialized equipment and expertise for their operation. All these requirements prevent microfluidic-based cell culture to be widely adopted. Here, we designed and implemented a versatile and easy-to-use perfusion cell culture microfluidic platform for multiple applications (VersaLive) requiring only standard pipettes. Here, we showcase the multiple uses of VersaLive (e.g., time-lapse live cell imaging, immunostaining, cell recovery, cell lysis, plasmid transfection) in mammalian cell lines and primary cells. VersaLive could replace standard cell culture formats in several applications, thus decreasing costs and increasing reproducibility across laboratories. The layout, documentation and protocols are open-source and available online at https://versalive.tigem.it/.
Changes in and asymmetry of the proteome in the human fetal frontal lobe during early development
Authors: Zhao Xiaotian , Liang Wenjia , Wang Wenjun , Liu Hailan , Zhang Xiaolei , Liu Chengxin , Zhu Caiting , Cui Baoxia , Tang Yuchun , Liu Shuwei
Published: September 2022

Inherent hemispheric asymmetry is important for cognition, language and other functions. Describing normal brain and asymmetry development during early development will improve our understanding of how different hemispheres prioritize specific functions, which is currently unknown. Here, we analysed developmental changes in and asymmetry of the proteome in the bilateral frontal lobes of three foetal specimens in the late first trimester of pregnancy. We found that during this period, the difference in expression between gestational weeks (GWs) increased, and the difference in asymmetric expression decreased. Changes in the patterns of protein expression differed in the bilateral frontal lobes. Our results show that brain asymmetry can be observed in early development. These findings can guide researchers in further investigations of the mechanisms of brain asymmetry. We propose that both sides of the brain should be analysed separately in future multiomics and human brain mapping studies.
Novel two-photon absorption compounds with different organic cations: facile synthesis, photophysical properties, detection of viscosity, and selective imaging of the endoplasmic reticulum in living cells
Authors: Cai Zhi-Bin , Lou Qiao-Xian , Li Sheng-Li , Chen Li-Jun , Ye Qing , Tian Yu-Peng
Published: September 2022

A novel acceptor–π–acceptor molecular rotor for the detection of viscosity was developed, and strategies for the design of ER-targeted two-photon excited fluorescent probes based on organic cations have been enriched.
A facile route for the recovery of the ligand of zeolitic imidazolate framework ZIF-94/SIM-1
Authors: Berned-Samatán Victor , Martínez-Izquierdo Lidia , Abás Elisa , Téllez Carlos , Coronas Joaquín
Published: September 2022

A facile route for the recycling of the organic ligand from ZIF-94/SIM-1 is reported with a recovery yield of 92.5 ± 2.8%.
Direct acylation and alkynylation of hydrocarbons via synergistic decatungstate photo-HAT/nickel catalysis
Authors: Liu Wenfeng , Ke Yang , Liu Chuhan , Kong Wangqing
Published: September 2022

Herein, we describe a protocol for the direct and selective acylation and alkynylation of the C(sp3)–H bonds of saturated hydrocarbons by synergistic decatungstate photo-HAT and nickel catalysis.
High-entropy amorphous oxycyanide as an efficient pre-catalyst for the oxygen evolution reaction
Authors: Sun Wenbin , Wang Yameng , Liu Shanshan , Lei Fengcai , Xie Junfeng , Tang Bo
Published: September 2022

Herein, a high-entropy amorphous oxycyanide porous nanocube pre-catalyst was developed for an improved oxygen evolution reaction (OER) performance.
Identifying and manipulating single atoms with scanning transmission electron microscopy
Authors: Susi Toma
Published: September 2022

A focused electron beam can be used to manipulate covalently bound impurities within crystal lattices with atomic precision.
Aftermath of irradiation: the stacking faults in crystal of giant supramolecule unexpectedly mended before total decay
Authors: Peresypkina Eugenia , Stöger Berthold , Virovets Alexander
Published: September 2022

Before decaying under X-rays, a single crystal of Ta-based supramolecule suffers a solid-to-solid transformation with unusual ascend of crystallographic symmetry.
Bi0.33(Bi6S9)Br compositing in Bi2S3 bulk materials forwards high thermoelectric properties
Authors: Guo Jun , Wang Zi-Yuan , Chen Lin , Zhu Yu-Ke , Zhou Ying , Shan Quan , Feng Jing , Ge Zhen-Hua
Published: September 2022

The Bi0.33(Bi6S9)Br intermediate alloy is used to optimize the thermoelectric properties of Bi2S3.
Investigating the efficiency of silica materials with wall-embedded nitroxide radicals for dynamic nuclear polarisation NMR
Authors: Besson Eric , Vebr Aurelien , Ziarelli Fabio , Bloch Emily , Gerbaud Guillaume , Queyroy Séverine , Thureau Pierre , Viel Stéphane , Gastaldi Stéphane
Published: September 2022

A wide range of mesoporous silicas functionalized with face-to-face TEMPO at a controlled distance has been studied as polarizing agents for DNP NMR. Their enhancement factors yield promising systems for various future applications.
Role of rotational inertia for collective phenomena in active matter
Authors: Caprini Lorenzo , Gupta Rahul Kumar , Löwen Hartmut
Published: September 2022

We investigate the effect of rotational inertia on the collective phenomena of underdamped active systems, showing that the increase of the moment of inertia favors motility induced phase separation and enhances spatial velocity correlations.
Alkali metal-modified crystalline carbon nitride for photocatalytic nitrogen fixation
Authors: Li Yang , Wang Baibing , Xiang Quan-Jun , Zhang Qin , Chen Gui
Published: September 2022

KN-HCN exhibited enhanced photocatalytic ammonia production because of the presence of a large number of cyano groups and the loading mode of potassium and sodium ions.
Random copolymerization strategy for non-halogenated solvent-processed all-polymer solar cells with a high efficiency of over 17%
Authors: Zhang Jiabin , Huang Qiri , Zhang Kai , Jia Tao , Jing Jianhua , Chen Yuting , Li Yuhao , Chen Yanwei , Lu Xinhui , Wu Hongbin , Huang Fei , Cao Yong
Published: September 2022

Regulating domain size via a random copolymerization strategy enables the high-efficiency non-halogenated solvent processing of all-polymer solar cells.
A structurally simple linear conjugated polymer toward practical application of organic solar cells
Authors: Yin Bingyan , Pang Shuting , Chen Zhili , Deng Wanyuan , Liu Zhitian , Duan Chunhui , Huang Fei , Cao Yong
Published: September 2022

PTTzF, a linear conjugated polymer donor featuring simple synthesis, high device efficiency, outstanding batch reproducibility, and good universality with different acceptors is a promising candidate for practical application of organic solar cells.
Mystifications and misconceptions of lignin: revisiting understandings
Authors: Souto Felipe , Calado Veronica
Published: September 2022

Lignin is a tricky and complex structure. The growing interest in its use requires a unanimous approach to its nature; so, misconceptions that have already been overcome and those perpetuated by those who are not familiar with its complexity do not spread.
Sustainability and efficiency assessment of vanillin allylation: in solution versus ball-milling
Authors: Breilly Damien , Fadlallah Sami , Froidevaux Vincent , Lamaty Frédéric , Allais Florent , Métro Thomas-Xavier
Published: September 2022

Allylation of phenols, a widely used reaction in multistep synthetic pathways, was herein investigated using mechanochemistry and compared to more conventional synthesis in solution.
Enabling perfusion through multicellular tumor spheroids promoting lumenization in a vascularized cancer model
Authors: Park Joonha , Kim Seunggyu , Hong Jiman , Jeon Jessie S.
Published: September 2022

Tumor microenvironment recapitulation focusing on perfusable multicellular tumor spheroid model construction via anastomosis of endothelial cells through the spheroid increases the overall growth and penetration of the anti-cancer drug.
Circularly polarized luminescence of encaged Eu(iii) and Tb(iii) complexes controlled by an inherently chiral remote unit
Authors: Godart Estelle , Della-Negra Oriane , Long Augustin , Insuasty Alberto , Arrico Lorenzo , Benetti Costanza , Antonetti Elise , Nava Paola , Cotelle Yoann , Vanthuyne Nicolas , Jean Marion , Pascal Simon , Dutasta Jean-Pierre , Di Bari Lorenzo , Martinez Alexandre
Published: September 2022

The Tb(iii)@cage presents CPL properties although the chiral CTV unit is remote from the coordinating moiety, suggesting chiral transfer between these two parts.
Visible light-driven photocatalytic removal of water pollutants by a carbon-modified magnetically active ternary TiO2 (Fe3O4/carbon/TiO2) composite
Authors: Ananthakrishnan Rajakumar , Das Priyanka
Published: September 2022

Remediation of organic pollutants from water using various techniques is a highly focused area in recent years, and visible light-aided heterogeneous photocatalysis is an emerging technique in this field.
Structure, morphology and photocatalytic performance of europium and fluorine co-doped bismuth vanadate
Authors: Xie Han , Zhang Wen , Gao Shengnan , Wang Jun , Zhang Dongliang , Wang Mitang
Published: September 2022

The synergistic effect of Eu and F reduces the band gap energy of BiVO4and improves its photocatalytic activity.
Electrochemically promoted annulation of aldehydes and carbazates: access to 2-alkoxy/aryloxy-5-substituted 1,3,4-oxadiazole and 1,3,4-oxadiazol-2(3H)-one derivatives
Authors: Li Hongjun , Tang Dong , Iqbal Zafar , Wan Yaya , Jiang Rui , Yang Zhixiang , Yang Jinhui
Published: September 2022

An efficient and eco-friendly electrosynthesis of 2-alkoxy/aryloxy-5-substituted 1,3,4-oxadiazoles, and 5-substituted 1,3,4-oxadiazol-2(3H)-ones has been developed through the annulation of aldehydes and carbazates.
Fabricating carbon nitride-based 3D/0D intramolecular donor–acceptor catalysts for efficient photoreduction of CO2
Authors: Song Xianghai , Mao Wei , Wu Yuanfeng , Wang Mei , Liu Xin , Zhou Weiqiang , Huo Pengwei
Published: September 2022

Construction of carbon nitride based 3D/0D intramolecular DA catalysts with enhanced optical and electrical properties for efficient photoreduction of CO2.
Anion-responsive self-assembled hydrogels of a phenylalanine–TREN conjugate allow sequential release of propranolol and doxorubicin
Authors: Pradhan Manas Kumar , Gupta Deepika , Namdev Kavthekar Rupesh , Anjali  , Miglani Chirag , Pal Asish , Srivastava Aasheesh
Published: September 2022

Self-assemblies of a phenylalanine–TREN conjugate undergo anion-responsive nanofiber-to-nanoglobule transformation and its hydrogels allow sequential release of entrapped drugs.
Efficient formation of hemoglobin bis-tetramers via selective acetylation of α-subunit amino groups by methyl acetyl phosphate
Authors: Kim Yuju , Kluger Ronald
Published: September 2022

Site-directed acetylation of hemoglobin, prior to cross-linking, leads to efficient protein–protein coupling to form the desired bis-tetrameric, an acellular oxygen carrier.
Preparation of a Ni3Sn2 alloy-type anode embedded in carbon nanofibers by electrospinning for lithium-ion batteries
Authors: Ibadulla Nurbol , Belgibayeva Ayaulym , Nurpeissova Arailym , Bakenov Zhumabay , Kalimuldina Gulnur
Published: September 2022

Ni3Sn2 intermetallic alloy encapsulated in a carbon nanofiber matrix (Ni3Sn2@CNF) was obtained by electrospinning. The Ni3Sn2@CNF anode produced a high initial discharge capacity of ∼1300 mA h g−1, later retaining ∼350 mA h g−1 after 100 cycles.
[2 + 2] Cycloaddition of phosphaalkenes as a key step for the reductive coupling of diaryl ketones to tetraaryl olefins
Authors: Arkhypchuk Anna I. , D'Imperio Nicolas , Wells Jordann A. L. , Ott Sascha
Published: September 2022

Mechanistically distinct from all other carbonyl-to-alkene conversion methodologies, the [2 + 2] cycloaddition of phosphaalkene intermediates is established as the enabling elementary step in this transformation.
A highly sensitive fluorescent sensor for ammonia detection based on aggregation-induced emission luminogen-doped liquid crystals
Authors: Zhan Xiyun , Liu Yanjun , Wang Fei , Zhao Dongyu , Yang Kun-Lin , Luo Dan
Published: September 2022

A novel fluorescent sensor based on an AIEgen-doped LC system was developed for ammonia detection. The change of LC orientation can be induced in the presence of ammonia, leading to the variation of fluorescence intensity.
Protonation induced redshift in the fluorescence of a pyridine derivative as a potential anti-counterfeiting agent
Authors: Devadiga Deepak , Ahipa T. N.
Published: September 2022

We report a simple compound i.e. (2,4,6-tris(4-(hexyloxy)phenyl)pyridine) as the potential anti-counterfeiting agent with solvatochromic, acidochromic, and aggregation-induced enhanced emission properties.
Biodegradable bioelectronics for biomedical applications
Authors: Lee Seunghyeon , M. Silva Saimon , Caballero Aguilar Lilith M. , Eom Taesik , Moulton Simon E. , Shim Bong Sup
Published: September 2022

Primary materials for biodegradable bioelectronics: conductive materials blended with biodegradable components, conjugated polymers with biodegradable moieties, naturally derived conjugated biopolymers, and aqueously dissolvable inorganic materials.
Hydrogen sulfide-releasing polyurethane/gelatin/keratin–TA conjugate mats for wound healing
Authors: Han Xiao , Wang Lijuan , Shang Yushang , Liu Xu , Yuan Jiang , Shen Jian
Published: September 2022

A keratin-thiobenzoic acid conjugate (KTC) was synthesized and incorporated with PU and gelatin to fabricate nanofibrous mats. These mats were capable of releasing H2S in a sustained way, which could increase the antioxidant ability and wound healing effect prominently.
H‐polarized plane wave diffraction by a slotted cylinder with different surface impedances: Solution by the analytical—Numerical approach
Authors: Tabatadze Vasil , Karaçuha Kamil , Alperen Ömer Faruk , Veliev Eldar
Published: September 2022

The study investigates the H‐polarized plane wave diffraction by a slotted cylinder with different surface impedances employing an analytical‐numerical approach. The solution is obtained by expressing the current distribution on the obstacle with Gegenbauer polynomials considering the edge conditions. To obtain the field and current distribution on the surface, the Leontovich boundary condition on each side of the slotted cylinder is employed. The results are compared with Dirichlet and Neumann boundary condition cases obtained previously. It is observed that the resonant field amplitudes and the location at the resonances strongly depend on the impedance values.
Optimal control of anisotropic Allen-Cahn equations
Authors: Blank Luise , Meisinger Johannes
Published: September 2022

This paper aims at solving an optimal control problem governed by an anisotropic Allen-Cahn equation numerically. Therefor we first prove the Frechet differentiability of an in time discretized parabolic control problem under certain assumptions on the involved quasilinearity and formulate the first order necessary conditions. As a next step, since the anisotropies are in general not smooth enough, the convergence behavior of the optimal controls is studied for a sequence of (smooth) approximations of the former quasilinear term. In addition the simultaneous limit in the approximation and the time step size is considered. For a class covering a large variety of anisotropies we introduce a certain regularization and show the previously formulated requirements. Finally, a trust region Newton solver is applied to various anisotropies and configurations, and numerical evidence for mesh independent behavior and convergence with respect to regularization is presented.
Mit Schicksalsschlägen umgehen – Posttraumatische Belastungsstörung in der Handtherapie
Authors: Reinhold Ina
Published: September 2022

Nach einer Handverletzung müssen nicht nur Knochen, Sehnen und Muskeln verheilen, sondern das Erlebte muss auch verarbeitet werden. In manchen Fällen kann es etwa nach einem Unfall zu einer posttraumatischen Belastungsstörung (PTBS) kommen. Dann ist es nötig, nicht nur die physischen, sondern auch die psychischen Symptomatiken zu beachten und zu behandeln.
Unabhängige Beschwerdestellen für die Psychiatrie in
Deutschland
Authors: Janse Jozina , Kulke Dieter
Published: September 2022

Ziel der Studie Erfassung der Bedeutung und Arbeitsweise von
unabhängigen Beschwerdestellen für die Psychiatrie.

Methodik Digitale und postalische Befragung.

Ergebnisse Die häufigsten Anlässe für Beschwerden
sind Unzufriedenheit mit der stationären Behandlung, der gesetzlichen
Betreuung und der Kommunikation mit den Patienten. Netzwerkarbeit gewinnt an
Bedeutung. Beschwerdeführende werden öfters weitervermittelt.
Vermehrte Anfragen von Männern und Suchtpatienten.

Schlussfolgerung Verbesserungsmöglichkeiten liegen in einer
verstärkten Gesetzesverankerung, der Förderung einer
trialogischen Besetzung und der Aufklärung durch Fachpersonal.
Pantoprazole Induced Acute Interstitial Nephritis in a Patient with
Diabetic Ketoacidosis
Authors: Tas Nesrin , Mengen Eda , Goncu Sultan , Tasar Sercin , Kiremitci Saba , Ucakturk Ahmet
Published: September 2022

Introduction

Childhood-onset type 1 diabetes mellitus (DM) is a common chronic metabolic disease
associated with life-threatening complications. Diabetic ketoacidosis (DKA) is an
acute complication of type 1 DM that has significant mortality mostly due to
cerebral edema. Other putative complications of DKA include hypokalemia,
hypophosphatemia, hypoglycemia, intracerebral and peripheral venous thrombosis,
rhabdomyolysis, acute pancreatitis, and acute kidney injury (AKI) (Murdoch IA et
al., Acta Paediatr 1993; 82:498–500).
Rhytidectomy—Information Patients Seek and Where They Find Answers
Authors: Fritz Christian , Ravin Emma De , Suresh Neeraj , Lowery Anne S. , Rajasekaran Karthik
Published: September 2022

Patients considering rhytidectomy often search for information online prior to in-office consultation. This study identifies the most searched queries regarding rhytidectomy and evaluates sources to which patients are directed. The search engine optimization tool Ahrefs was utilized to extract Google metadata on searches performed in the United States. Frequently asked questions were categorized by topic; websites were categorized by type. Journal of the American Medical Association (JAMA) benchmark criteria enabled information quality assessment. A total of 565 questions for three search phrases were extracted (265 “facelift,” 265 “face lift,” and 35 “rhytidectomy”). The majority of monthly searches in the facelift and face lift groups pertained to procedural cost, which was significantly higher than in the rhytidectomy group (52.9% and 50.7 vs. 0.0%, ANOVA p <0.001). The mean JAMA score for private practice sources (1.2 ± 0.42) was significantly lower than that of academic pages of (2.3 ± 1.9, p = 0.026) and commercial sources (3.0 ± 0.82, p = 0.008). The most popular destinations for rhytidectomy were California and Mexico (630 and 440 searches/month). Online searches for facelifts often revolve around the topic of cost and frequently direct patients to websites that provide inadequate information on authorship, attribution, disclosure, and currency.
Biocatalytic Synthesis of α,β-Unsaturated 2-Keto Acids and Derivatives Using the Promiscuous Aldolase, NahE
Authors: Palmer David R. J. , Fansher Douglas J. , Ngwira Niza , Salehi Ahmad Reza , Woods Jerome , Cascão Amanda
Published: September 2022

Type I aldolases catalyze carbon–carbon bond-forming reactions to form a diverse set of products in nature but often display high selectivity for their natural substrates. One such aldolase, NahE, is known to catalyze the condensation of pyruvate with a wide range of aldehydes to give trans-4-phenyl-2-oxo-3-butenoic acids under mild aqueous conditions. These α,β-unsaturated 2-oxo acids are versatile intermediates for synthetic transformations. NahE has also been used for the synthesis of α-fluoro-β-hydroxy esters, β-hydroxy esters, and quinaldic acids. However, a thorough study of the substrate scope on a practical scale has not been performed for the native NahE-catalyzed aldol condensation reaction. Here we report that NahE can accept >35 (hetero)aromatic and aliphatic aldehydes. Most condensation products derived from substituted benzaldehydes were isolated in >95% yield without need for further purification, while non-benzaldehyde substrates gave the corresponding products in isolated yields between 26% and 98%. Reactions could be performed on gram scale. These products could be converted into α,β-unsaturated carboxylic acids in up to 93% yield over two steps. This reaction sequence was also performed using whole cells in up to 79% yield. This work demonstrates that NahE is a robust, efficient, and versatile catalyst for organic synthesis.
The Temporal Subcutaneous Brow Lift with Orbicularis Oculi Muscle Elastic Flap: Technical Considerations, Systematic Review, and Terminology Standardization
Authors: Pascali Michele , Massarelli Olindo
Published: September 2022

Objectives As the face ages, cosmetic changes in the periorbital region including eyebrow ptosis, sagging in the lateral temporo-orbital region with superior eyelid hooding, ptosis of orbicularis oculi muscle associated with drooping of the malar area with multiple “crow feets”, a deeper lid-cheek junction, and malar festoons also occur. All these periorbital structures should be considered as a single anatomical entity.

Methods Numerous techniques have been described to correct brow aesthetics in facial rejuvenation. We report the senior author's (M.P.) current approach utilizing a temporal subcutaneous brow lift (TSBL) associated with an orbicularis oculi muscle (OOM) elastic flap. Furthermore, a systematic review of the literature was performed comparing the different surgical approaches striving to clarify its terminology. A total of 298 patients underwent this procedure in 4 years period. Of these, 230 patients, with at least 12 months of follow-up, were submitted to subjective and objective methods to evaluate the self-perception of scar and their overall aesthetic satisfaction. A committee of experts, blinded to each other's assessment, evaluated the same outcomes. Total eyebrow's tail lift was measured and recorded for each patients.

Results The most satisfying aspect of these techniques is the dramatic periorbital rejuvenation and preservation of the patient's original youthful identity. In fact, the postoperative results appear very natural and do not suffer from an “operated” look. This aspect is noticeable from both the surgeon's and the patient's perceptions. There were no major complications in any of the cases.

Conclusions The proposed TSBL with OOM elastic flap technique, in the hands of senior author (M.P.) has emerged as a reliable, effective, and highly reproducible method to treat sagging and aging of the lateral region of the orbit, even without associated blepharoplasties.
Disilathiane as a Sulfur Source for the Construction of Isothiochromenes and Benzo[b]thiophenes by Copper-Catalyzed endo-Selective Hydrothiolation
Authors: Sakai Norio , Nakajima Takumi , Takeuchi Ryuki , Oomori Keita , Ishida Kento , Ogiwara Yohei
Published: September 2022

A copper-catalyzed construction of isothiochromenes and benzo[b]thiophenes via annulation with 1,1,1,3,3,3-hexamethyldisilathiane as a sulfur source is described. In the isothiochromene synthesis, the use of the disilathiane as a sulfur source successfully controls the regioselectivity of cyclization to afford the isothiochromene as the sole product. The present strategy can be applied to the synthesis of 2-aryl/2-alkylbenzo[b]thiophenes.
Risk Factors for Musculoskeletal Injury in CrossFit: A Systematic Review
Authors: Mehrab Mirwais , Wagner Robert Kaspar , Vuurberg Gwendolyn , Gouttebarge Vincent , de Vos Robert-Jan , Mathijssen Nina Maria Cornelia
Published: September 2022

The objective of this systematic review was to identify potential risk factors for injury in CrossFit participants. Embase, Medline, Web of Science, Cochrane, CINAHL, Google Scholar, and SportDiscuss databases were all searched up to June 2021. Cohort studies that investigated risk factors for CrossFit injuries requiring medical attention or leading to time loss in sports were included. A best-evidence synthesis was performed combining all the outcomes from prospective cohort studies. From 9,452 publications identified, we included three prospective cohort studies from which two had a low risk of bias and one a high risk of bias. The studies examined 691 participants of whom 172 sustained an injury. There was limited evidence that switching between prescribed and scaled loads during training is associated with increased injury risk and that increased duration of participation is a protective factor for injury. This could mean that novice CrossFit athletes and those increasing their training load should have closer supervision by CrossFit coaches. These risk factors should be considered when developing preventive interventions.
Comparison of Mineral Trioxide Aggregate and Biodentine for Open Apex Management in Children with Nonvital Immature Permanent Teeth: A Systematic Review
Authors: Ravindran Vignesh , Jeevanandan Ganesh , Marimuthu Madhulaxmi , Panda Suman , Syed Ather Ahmed , Vishwanathaiah Satish , Khanagar Sanjeev , Maganur Prabhadevi C.
Published: September 2022

Tricalcium silicate cements have long been used in dentistry for management of open apex. Biodentine was introduced to overcome the disadvantages of mineral trioxide aggregate (MTA). The aim of this systematic review was to compare the success rates of biodentine and MTA as a material of choice for the management of open apex in children with nonvital immature permanent teeth. PubMed/Medline, Scopus, EMBASE, Cochrane, and Google Scholar were searched until November 30, 2021, with the search terms young permanent teeth, immature permanent teeth, open apex, MTA, and biodentine. Based on the inclusion criteria, the articles were selected following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and assessed for quality using a risk-of-bias assessment tool. The outcomes of the studies were qualitatively synthesized. A total of 379 studies were identified and after refinement only two studies met the eligibility criteria. Both the studies were performed in children with nonvital pulp status. One of the studies showed a clinical success of 91.66% for MTA and 100% for biodentine in revascularization cases while the other study showed 100% for both the materials in apexification cases. Radiographic success was 100% for both the materials at the end of the follow-up period in both the studies. Treatment modality can create heterogeneity that does not allow making a pooled conclusion for the two materials collectively, which is the case in this review where one study used revascularization, while the other used apexification. An overall high risk of bias was noticed for the selected studies. With high risk of bias and low quality of evidence, a strong definitive conclusion cannot be arrived at. Further studies with proper randomization and minimal risk of bias are required to provide a conclusive result. However, as per the included studies, biodentine can be a material of choice for revascularization while both MTA and biodentine can be used for apexification procedures.
Flow volume measurement of arterial venous and cerebrospinal fluid in patients with multiple sclerosis
Authors: Aglamis Serpil , Gönen Murat
Published: September 2022

Background Multiple sclerosis (MS) is usually described as an autoimmune disease, although the exact mechanism of the disease remains unknown. There have been studies reporting that venous flow abnormalities may be involved in the pathogenesis of MS or many of the associated clinical manifestations.

Objective The aim of this study was to evaluate flow volumes of the middle cerebral artery (MCA), transverse sinus (TS), and cerebral aqueduct using phase contrast magnetic resonance imaging (PC-MRI) in relapsing-remitting MS patients and a control group.

Methods We included 34 patients diagnosed by the McDonald criteria, revised in 2017, as well as 15 healthy controls matched by age and sex. The MRI scans were performed using a 1.5-T superconducting scanner. Axial T1-weighted, T2-weighted, and PC-MRI sequences were performed for the quantitative investigation of flow volume measurements. Quantitative analyses of flows were performed using flow analyses program PC-MRI angiography software. A circular region of interest was placed manually into the cerebral aqueduct, bilateral MCA, and TS.

Results Flow volumes of the cerebral aqueduct and MCA were not statistically significant between the MS and control groups. The flow volumes of the TS for the patient group were lower than those of the control group, and this difference was statistically significant.

Conclusions A reduced TS flow volume in MS patients was noted in the present study when compared with the control group, suggesting a relation between venous pathologies and MS. Further studies are needed to understand whether this relation is causal or epiphenomenal.