bluuebunny/crossref_metadata_2025 huggingface dataset:
Amyloid precipitation in biofluids using a structure-specific chemical antibody
Authors: Rodrigues Margarida , Bhattacharjee Payel , Brinkmalm Ann , Do Dung , Pearson Colin , De Suman , Ponjavic Aleks , Varela Juan , Ruggeri Francesco , Baudrexel Isabelle , Lee Ji , Carr Alexander , Kulenkampff Klara , Knowles Tuomas , Zetterberg Henrik , Snaddon Thomas , Gandhi Sonia , Lee Steven , Klenerman David
Published: November 2020

The composition of soluble toxic protein aggregates formed in vivo is currently unknown in neurodegenerative diseases, due to their ultra-low concentration in human biofluids and their high degree of heterogeneity. We introduce the structure-specific chemical antibody; a Y shaped, bioinspired small molecule with a dimeric region to mimic avidity, and an attachment region to mimic the Fc region. Our probe, capture molecule for amyloid precipitation (CAP-1), consists of a derivative of Pittsburgh compound B (dimer) to target the cross β-sheets of amyloids and a biotin moiety for surface immobilization. By coupling CAP-1 to magnetic beads, we targeted the amyloid structure of protein aggregates in human cerebrospinal fluid, isolated them for analysis and then characterised them using single-molecule fluorescence imaging and mass spectrometry. AP allows unbiased determination of the molecular composition and structural features of the in vivo aggregates, formed in neurodegenerative diseases, that are present in biofluids.
Non-isothermal phase-field modelling with thermocapillary convection: Laser-written in-plane SiGe heterostructures for photonic applications
Authors: Aktas Ozan , Yamamoto Yuji , Kaynak Mehmet , Peacock Anna
Published: November 2020

Advanced solid-state device applications, including semiconductor lasers, waveguide Bragg gratings, and modulators, require nanoscale engineering of the electronic bandgap and refractive index. Heterostructures, which are semiconductor structures with a position-dependent chemical composition, are building blocks of these devices, enabling control over the carriers and light. However, existing epitaxial growth methods are limited to fabrication of vertical heterostructures between dissimilar semiconductors successively grown layer by layer. Here, we report the use of three dimensional (3D) finite-element-method (FEM)-based non-isothermal phase-field modelling with thermocapillary convection to investigate a new concept for laser inscription of in-plane longitudinal and transverse heterostructures within silicon-germanium (Si1-xGex) alloy thin films. The modelling has been supported by exploratory experimental work using Si0.5Ge0.5 layers epitaxially grown on a silicon substrates. Results of the phase-field simulations reveal that various in-plane SiGe heterostructures and superlattices can be fabricated by controlling the steady-state and transient effects of the laser scanning on phase segregation through modulation of the laser power, scan speed and beam position during solidification of the SiGe epilayers. Optical simulations are used to demonstrate the potential for two new photonic devices based on in-plane SiGe heterostructures written at different scan speeds (1-200 mm s-1): (i) graded-index waveguides with Ge-rich (70%) cores, and (ii) waveguide Bragg gratings with nanoscale periods (Λ=100-500 nm). Periodic heterostructure formation via sub-millisecond modulation of the laser processing parameters opens a route for post-growth fabrication of in-plane quantum wells and superlattices in semiconductor alloy epilayers.
An evaluation of the interpretability and predictive performance of the BayesR model for genomic prediction
Authors: Mollandin Fanny , Rau Andrea , Croiseau Pascal
Published: November 2020

Background: Technological advances and decreasing costs have led to the rise of increasingly dense genotyping data, making feasible the identification of potential causal or candidate markers. Custom genotyping chips, which represent a cost-effective strategy to combine medium-density genotypes with a custom genotype panel, can capitalize on these candidates to potentially yield improved accuracy and interpretability in genomic prediction. A particularly promising model to this end is BayesR, which divides markers into four effect size classes (null, small, medium, and large). The flexibility of BayesR has been shown to yield accurate predictions and promise for quantitative trait loci (QTL) mapping in real data applications, but an extensive benchmarking in simulated data is currently lacking.Results: Based on a set of real genotypes, we generated simulated data under a variety of genetic architectures, phenotype heritabilities, and polygenic variances, and we evaluated the impact of excluding (50k genotype data) or including (50k custom genotype data) causal markers among the genotypes. We define several statistical criteria for QTL mapping using BayesR output (maximum a posteriori rule, non-null maximum a posteriori rule, posterior variance, weighted cumulative inclusion probability), including several based on sliding windows rather than individual markers to account for linkage disequilibrium. We compare and contrast these statistics and their ability to accurately prioritize known causal markers. Overall, we confirm the strong predictive performance for BayesR in moderately to highly heritable traits, particularly for 50k custom data; in cases of low heritability or weak linkage disequilibrium with the causal marker in 50k genotypes, QTL mapping is a challenge, regardless of the criterion used.Conclusion: BayesR is a promising approach to simultaneously obtain accurate predictions and interpretable classifications of SNPs into effect size classes. Although QTL mapping is unsurprisingly easiest for highly heritable phenotypes and large QTLs, we illustrated the performance of BayesR in a variety of simulation scenarios, and compared the advantages and limitations of each. Among those considered, the weighted cumulative inclusion probability appears to provide the best mapping results, even under less favorable conditions. Finally, we quantify the advantage that can be gained by incorporating causal mutations on a custom genotyping chip.
Repair of Acute Diaphragmatic Injury Diagnosed within Few Days of Trauma via Thoracic Approach
Authors: Hamad Abdel-Mohsen Mahmoud , Elatafy Elatafy E
Published: November 2020

BackgroundDiagnosis of diaphragmatic injury (DI) in acute trauma sittings is challenging and missed or delayed detection is not uncommon. The surgical approach for repair of acute diaphragmatic injury is mainly determined by the presence of associated injuries. In the majority of cases repair is accomplished through exploratory laparotomy together with dealing with associated intra-abdominal injuries.Cases presentationWe reported 5 cases (4 males and 1 female), age ranging from 21 to 52 years, with acute blunt diaphragmatic injury. There was a latent period of few days (ranging from 3 to 8 days) before definite diagnosis and surgical intervention. All patients were managed through small lower posterolateral thoracotomy approach without complication.ConclusionRepair of diaphragmatic injury via thoracic approach is easy, safe, and efficient. We recommend thoracic approach especially on the right side even in acute situation in absence of other indications for laparotomy.
Microbiome of the Black Sea Water Column Analyzed by Genome Centric Metagenomics  
Authors: Cabello-Yeves Pedro J. , Callieri Cristiana , Picazo Antonio , Mehrshad Maliheh , Haro-Moreno Jose M. , Roda-Garcia Juan J. , Dzhembekova Nina , Slabakova Violeta , Slabakova Nataliya , Moncheva Snejana , Rodriguez-Valera Francisco
Published: November 2020

Background: The Black Sea is the largest brackish water body in the world, although it is connected to the Mediterranean Sea and presents an upper water layer similar to some regions of the former albeit with lower salinity and (mostly) temperature. In spite of its well-known hydrology and physico chemistry, this enormous water mass remains poorly studied at the microbial genomics level. Results: We have sampled its different water masses and analyzed the microbiome by classic and genome-resolved metagenomics generating a large number of metagenome-assembled genomes (MAGs) from them. The oxic zone presents many similarities to the global ocean while the euxinic water mass has similarities to other similar aquatic environments of marine or freshwater (meromictic monimolimnion strata) origin. The MAG collection represents very well the different types of metabolisms expected in this kind of environments and includes Cyanobacteria (Synechococcus), photoheterotrophs (largely with marine relatives), facultative/microaerophilic microbes again largely marine, chemolithotrophs (N and S oxidizers) and a large number of anaerobes, mostly sulfate reducers but also a few methanogens and a large number of “dark matter” streamlined genomes of largely unpredictable ecology. Conclusions: The Black Sea presents a mixture of similarities to other water bodies. The photic zone has many microbes in common with that of the Mediterranean with the relevant exception of the absence of Prochlorococcus. The chemocline already presents very different characteristics with many examples of chemolithotrophic metabolism (Thioglobus) and facultatively anaerobic microbes. Finally the euxinic anaerobic zone presents, as expected, features in common with the bottom of meromictic lakes with a massive dominance of sulfate reduction as energy generating metabolism and a small but detectable methanogenesis.We are adding critical information about this unique and important ecosystem and its microbiome.
Pleomorphic Xanthoastrocytoma, Anaplastic Pleomorphic Xanthoastrocytoma, and Epithelioid Glioblastoma: Case Series With Clinical Characteristics, Molecular Features and Progression Relationship
Authors: Lin Zhiying , Yang Runwei , Zheng Haojie , Li Zhiyong , Yi Guozhong , Han Huixia , Wu Qianchao , Qi Songtao , Liu Yawei , Guanglong Huang
Published: November 2020

Background: Pleomorphic xanthoastrocytoma (PXA), anaplastic pleomorphic xanthoastrocytoma (A-PXA), and epithelioid glioblastoma (E-GBM) show overlapping features. However, little is known about their clinical characteristics, molecular features and progression relationship. Methods: Fourteen patients diagnosed at Nanfang Hospital from 2016 to 2019 were enrolled, including eleven PXA patients, two A-PXA patients, and one E-GBM patient. All tumor tissue samples of fourteen patients were examined by immunohistochemistry staining (MGMT, VEGF, BRAF-V600E, etc.). The recurred tumor tissue of the E-GBM patient arising from A-PXA was detected for 11 glioma markers (MGMT, BRAF-V600E, etc.) and chromosome 1p/19q by next generation sequencing (NGS). Results: The mean age of 13 patients with PXA or A-PXA was 25.4 years, twelve of whom were burdened with tumors at supratentorial regions. VEGF showed positive expression in the tumor samples of 13 patients, MGMT positive in 10 patients, and BRAF-V600E positive in 7 patients. As for the tumor sample of the E-GBM patient survived for up to 10 years after the fourth resections, BRAF V600E was wild-type in the sample obtained from the first surgery while it was mutant in the second, third, and fourth surgery. In the contrast, the promoter status of MGMT in four operations were unmethylated. The NGS results showed that the mutation frequencies of BRAF V600E in the second surgery, the third surgery and the fourth surgery were 14.06%, 9.13% and 48.29% respectively. Conclusions: Collectively, the results suggest that patients with A-PXA may relapse multiple times and eventually progress to E-GBM with BRAF-V600E mutation.
Influencing Factors and Prognostic Significance of TIL Subset Abundance in Head and Neck Squamous Cell Carcinoma
Authors: Wang Xuezhou , Zhou Li , Dong Ruifeng , Li Baihui , Yu Wenwen , Ren Xiubao , Zhang Xinwei
Published: November 2020

Objective: To evaluate the abundance of Foxp3-positive tumor-infiltrating lymphocytes (Foxp3+TILs), CD103+cells, CD8+TILs, and CD3+TILs in tissue specimens of 85 head and neck squamous cell carcinoma (HNSCC) and analyze the associations of their abundance with the clinicopathological features and prognosis.Methods: Immunohistochemistry was performed to detect the abundance of immunocyte subsets. Both correlation analysis and multivariate logistic regression analysis were used to analyze the associations between the frequency of these cell subsets and clinicopathological features in HNSCC. Kaplan–Meier analysis and the Cox proportional-hazards model were utilized to evaluate the effects of these immunocytes on the prognosis of patients with HNSCC.Result: Multivariate logistic regression analysis showed that an independent association of Foxp3+TILs abundance with preoperative chemotherapy (PC) was negative (P=0.018), and that with smoking index (P=0.001) and N stage (P=0.012) was positive. Multivariate Cox model revealed that the high abundance of Foxp3+TILs was independently associated with short recurrence-free survival (RFS) (P=0.015) and poor overall survival (OS) (P=0.015). The high frequency of CD103+cells was independently related to long RFS (P=0.001) and favorable OS (P<0.001). The population with a high abundance of CD8+TILs and CD103+immunocytes in HNSCC tissues exhibited optimal RFS and OS, while the sub-group with a low frequency of CD8+TILs and CD103+immunocytes showed poor RFS and OS. Moreover, Spearman’s correlation analysis revealed that the frequency of CD103+cells was positively correlated to the abundance of CD8+TILs in HNSCC (P<0.001).Conclusion: Chemotherapy eliminates the frequency of Foxp3+TILs and improves the immune tumor microenvironment (iTME) of HNSCC. On the other hand, heavy smoking upregulates the abundance of Foxp3+TILs in HNSCC tissues and disrupt the balance of immune homeostasis in iTME. Additionally, both Foxp3+TILs and CD103+cells might be potential independent prognostic indicators of HNSCC.
AUDIT OF SEPSIS IN AN INDIAN TERTIARY CARE CENTRE
Authors:   MRCS (Edinburgh), MRCS (Glasgow), MCEM (U.K.)., Dasgupta Indraneel , Sathindra Sasmita B. ,   MRCS (Edinburgh), MRCS (Glasgow), MCEM (U.K.)., Dkhar Neris ,   MRCS (Edinburgh), MRCS (Glasgow), MCEM (U.K.).
Published: November 2020

Our audit titled audit of sepsis in an Indian tertiary care Center was conducted to assess the percentage of patients in whom the SEPSIS 1 HOUR BUNDLE was followed in our emergency and the steps taken to improve it in our hospital. The study was conducted in a tertiary care center Peerless Hospital and B.K.Roy research center, Kolkata, India. The sample size for the audit is 132. The study was conducted over a period of 1year . As per the Surviving Sepsis guidelines 2017, it was said that the initial resuscitation for sepsis should begin within 1 hour of recognition of sepsis, to decrease the mortality. The components of surviving sepsis bundle is IV crystalloid infusion, blood cultures, IV antibiotics, lactate measurement and early initiation of vasopressors to maintain MAP >65mmHg. From the above study period of 1 year, 67% of the patients were above 60 years and 33% of the patients were below 60 years of age. With this guideline reference, in our audit, we found that 66% of patients received IV crystalloids within 1 hour, in 23% of patients lactate was measured within 1 hour of recognition, blood cultures were taken within 1 hour in 49% of patients, 46% of patients received antibiotics within 1 hour. The lack of awareness regarding the importance of lactate clearance has led to delay in lactate measurement and only 23% of patients had lactate measured within 1 hour. All Emergency departments should have a sepsis lead and a sepsis protocol. Education and training about the importance of 1 hour bundle should be done for wider team for early recognition and instigation of optimal care.
ANÁLISE DE MATERIAIS EDUCATIVOS SOBRE PREVENÇÃO DE SUICÍDIO: TIPOS DE CONTEÚDOS
Authors: Marques da Silva Santos Matheus , Sales Antonio , De Souza Giovana Marcelino Stilben , Rodrigues Mariana Peres , Bento Leda Márcia Araújo
Published: November 2020

A publicidade em saúde com teor educativo manifesta-se como matéria prima para promoção e prevenção da saúde e seus agravos. Nesse contexto, os materiais produzidos na campanha “Setembro Amarelo” objetivam a instrução sobre condutas fundamentais em casos de apresentação de sinais de alerta para o risco da ideação e tentativa suicida. Por compreender a importância de tais orientações para familiares e profissionais, este trabalho pauta-se na análise qualitativa dos tipos de conteúdo presentes em dois desses materiais. Dessa maneira, averiguou-se a assertividade entre a escolha dos tipos de conteúdo utilizada, que podem ser factuais, conceituais, procedimentais e atitudinais, e sua efetividade no combate ao suicídio. Cada um desses conteúdos, em conjunto ou isoladamente, trazem consigo certo grau de profundidade capaz de sensibilizar e tornar possível a internalização de boas práticas, como escuta qualificada pelos profissionais da saúde e a detecção familiar precoce de situações de risco aumentado de autoviolência pré-anunciada pelo desejo cometer suicídio. Portanto é imprescindível que a elaboração dos materiais de prevenção ao suicídio seja embasada no conhecimento das teorias dos conteúdos de Antoni Zabala.
CUSTO DA OBESIDADE NA ADOLESCÊNCIA ENTRE 2008 E 2018 A PARTIR DOS DADOS DO DATASUS
Authors: Moura Ana Regina Leão Ibiapina , De Santana Andreia Aparecida Andrade , De Alencar Jaine Francielle Ribeiro , De Carvalho Tuane Rodrigues , De Moraes José Fernando Vila Nova
Published: November 2020

O objetivo do presente estudo foi analisar os gastos do Sistema Único de Saúde (SUS) com o tratamento da obesidade em adolescentes de 15 a 19 anos. Os dados foram analisados a partir do Serviço de Informação Hospitalares (SIH) do SUS, processados e disponibilizados pelo Departamento de Informática do SUS (DATASUS). As opções de pesquisa escolhida foram baseadas nos gastos com o tratamento da obesidade para a faixa etária de 15 a 19 anos, sexo masculino e feminino, e as diferentes regiões do país. Foram analisados os anos de 2008 a 2018. Percebeu-se um aumento no gasto com o tratamento da obesidade nessa faixa etária. Em 2008 foram gastos R$ 190.015,83 enquanto que em 2018 o valor total foi de R$ 918.564,40. O valor total dos gastos no período analisado foi de R$ 5.570.080, 93. Quando analisados por sexo, entre 2008 e 2018 observou-se que as meninas foram mais onerosas do que os meninos (R$ 4.035.282,05 vs. R$ 1.534.798,88, respectivamente). Já na comparação entre as regiões, fica evidente um maior gasto no tratamento da obesidade na Região Sul, seguida da Região Sudeste. Conclui-se que nos últimos anos houve um aumento significativo com o gasto do tratamento da obesidade em adolescentes e que isto acompanha o aumento da prevalência de excesso de peso nessa faixa etária. Ademais, as meninas mostraram-se mais caras para o sistema e as Regiões Sul e Sudeste concentraram grande parte destes gastos.
TRADUÇÃO E VALIDAÇÃO DE ALGORITMO PARA IDENTIFICAÇÃO DE LESÃO HEPÁTICA INDUZIDA POR MEDICAMENTOS
Authors: Lunardelli Michele John Müller , Becker Matheus William , Blatt Carine Raquel
Published: November 2020

A lesão hepática induzida por medicamentos é um tipo de reação adversa a medicamento (RAM), cuja ocorrência é a causa de falha hepática fulminante em 13% a 30% dos casos. O Russel Uclaf Causality Assessment Method (RUCAM) é um algoritmo específico para a determinação de lesão hepática induzida por medicamentos. O objetivo deste trabalho é traduzir e validar o algoritmo RUCAM para o português. Método: Foi realizada a tradução e tradução inversa do algoritmo. A validação de conteúdo foi verificada pela aplicação do algoritmo traduzido a um caso real, por um grupo de médicos, farmacêuticos e enfermeiros. Resultados: Foram obtidas 41 aplicações do algoritmo. O tempo médio de aplicação foi de 17 + 10 minutos. O escore médio foi de 7,58 + 3,48 (provável relação de causalidade). As diferenças do escore para as diferentes categorias profissionais não foi estatisticamente significativa (p=0,800). Discussão: O algoritmo RUCAM possui sete domínios: tempo de início da doença hepática, duração da doença, fatores de risco, uso concomitante de medicamentos, exclusão de causas alternativas, história prévia do medicamento suspeito e resposta à reexposição ao medicamento. Tais informações permitem maior acurária na confirmação da suspeita da RAM, favorecendo a identificação dos medicamentos com potencial hepatotóxico. Conclusão: O algoritmo RUCAM traduzido para o português se mostrou uma ferramenta útil para a investigação de causalidade entre a lesão hepática e medicamentos, que pode ser aplicado por médicos, enfermeiros e farmacêuticos.
PLANTAS MEDICINAIS UTILIZADAS POR QUILOMBOLAS NA GESTAÇÃO E LACTAÇÃO, E RISCOS NO USO INDISCRIMINADO
Authors: Campos Poliana Souza Santos , Correia Renata , Marisco Gabriele
Published: November 2020

Estudos em comunidades quilombolas sobre plantas medicinais utilizadas durante a gestação e lactação ainda são incipientes e os dados sobre as espécies medicinais que causam efeitos teratogênicos, embriotóxicos, abortivos e contraindicados na lactação são considerados poucos e muitas vezes contraditórios. Diante disso, este trabalho teve como objetivo realizar um levantamento etnobotânico e discutir sobre o uso das plantas com fins medicinais utilizadas por gestantes e lactantes de comunidades quilombolas de Vitória da Conquista – Ba. Os dados foram adquiridos por meio de entrevistas semiestruturadas e coleta das plantas. Foi possível observar que a maioria das mulheres não tem assistência médica e fazem uso de plantas sem acompanhamento da equipe de saúde. O levantamento mostrou que 27 espécies são usadas frequentemente durante o período de gestação e lactação, dentre elas 7 são contraindicadas, merecendo destaque às plantas erva cidreira (Lippia alba) e erva doce (Foeniculum vulgare) por serem amplamente usadas para diferentes fins medicinais. Diante disso, foi possível verificar que as mulheres fazem uso de plantas contraindicadas na gestação e lactação, necessitando em caráter de urgência de orientação correta quanto ao uso de espécies medicinais, bem como mecanismos de assistência que alertem sobre o uso das plantas de forma indiscriminada e os ricos na gestação e/ ou lactação.
AVALIAÇÃO DO CONHECIMENTO E DA CONDUTA DE URGÊNCIA PÓS-TRAUMATISMO DENTÁRIO
Authors: Marques Gabriel Dos Santos , Dos Santos Jean Alves , De Sena Sara Sabrina , Machado Nathália Evelyn da Silva , Do Prado Rosana Leal , Marsicano Juliane Avansini , Mori Graziela Garrido
Published: November 2020

Traumatismos dentários são muito comuns devido a quedas e acidentes, afetando principalmente crianças em idade escolar. O adequado atendimento de urgência para estes casos é fundamental para o estabelecimento da saúde bucal e qualquer pessoa presente no local do acidente pode colaborar decisivamente com o prognóstico do caso. Assim, o presente estudo teve como objetivo avaliar as condutas de professores e funcionários de escolas públicas ou privadas que trabalham com crianças entre 7 a 11 anos, frente ao traumatismo e à avulsão dentária. Inicialmente, aplicou-se o questionário proposto como ferramenta de avaliação para 50 professores e funcionários de escolas com o objetivo de validação daquela. Após coleta e análise dos questionários respondidos, realizou-se pequenas alterações e nova aplicação do questionário validado. Nesta segunda etapa foram incluídos 231 professores e funcionários de escolas da rede pública e privada, que trabalham com crianças de 7 a 11 anos. Os dados foram tabulados e analisados estatisticamente por meio do teste do Qui-quadrado e teste G (p<0.05). Somente 32,9% dos participantes levariam o acidentado imediatamente para o dentista. Cerca de 26% dos participantes já tiveram experiência pessoal com traumatismo dentário, sendo que 10% sofreram avulsão dentária. Quando perguntados sobre o reimplante imediato, somente 14,7% o faria e somente 20,3% fariam a limpeza correta do dente. O leite como meio de conservação adequado representou 16% das respostas. Os professores e funcionários de escolas públicas e privadas apresentam baixo conhecimento sobre traumatismo dentário e as condutas desta população podem ser aprimoradas por meio de campanhas de esclarecimento.
CARACTERIZAÇÃO DO PERFIL ASSISTENCIAL DOS PACIENTES ATENDIDOS EM UMA UNIDADE DE INTERCORRÊNCIA ONCOLÓGICA
Authors: Nunes Pinto Fernandes Caroline , Ximenes Maria Lia Coutinho Carvalho , De Almeida Mirizana Alves
Published: November 2020

OBJETIVO: Caracterizar o perfil assistencial dos pacientes atendidos em uma unidade deintercorrência oncológica. METODOLOGIA: Pesquisa quantitativa, descritiva edocumental, aprovada com protocolo nº 2.926.639. O Local do estudo ocorreu no HospitalHaroldo Juaçaba (HHJ). População composta por pacientes admitidos na Unidade deintercorrência de Câncer. Foram analisados retrospectivamente os prontuários eletrônicos dospacientes atendidos entre os meses de fevereiro a abril de 2018 na Unidade, coletando dadossócio demográficos e clínicos. RESULTADOS: Dos 100 prontuários que compuseram aamostra, identificou-se uma média de idade de 57 anos (+15 anos), sendo 68% do sexofeminino. Quanto ao estado civil, a maior parcela da amostra estudada era casada (59%).Sobre a procedência 65% eram da capital e 35% do interior do estado. Houve registro decomorbidades em 47% dos pacientes. A terapêutica mais realizada foi à quimioterapia (82%).Quanto à localização primária do tumor nestes pacientes os tumores gastrointestinais (23%),câncer de mama (21%) foram os predominantes. Havia registro de complicações durante apermanência na unidade em 84% dos prontuários. Apresentando um nível de funcionalidadebem variado, 40% se mostraram independentes, 26% necessitavam de uma dependênciaocasional e 34 % eram de totalmente dependentes. Foi identificado a solicitação em apenas13% dos prontuários. No entanto ocorreu atendimento fisioterapêutico em 55% dos pacientesda unidade. CONCLUSÃO: Observa-se a necessidade de novas investigações cientificas,considerando a escassez de estudos sobre a temática, para que sejam identificadas eelaboradas estratégias de intervenção voltadas a minimizar os efeitos do tratamentooncológico.
Comparative Assessment of Antibacterial Efficacy of Commercially Available Different Dental Gels: An In-vitro Study
Authors: Kshirsagar Minal M. , Dodamani Arun S. , Vishwakarma Prashanth , Mali Gaurao , Khobragade Vrushali Ramdas , Deokar Rahul Nivrutti
Published: November 2020

Background:

The topical routes of administering drug have certain visible advantages as direct application of a
drug to the site of action and persistence of action for prolonged duration. More stability and better application property of
gel cause its use for topical application.

Objectives:

To determine and compare antibacterial efficacy of commercially available different dental gels.

Methods:

For the evaluation of antibacterial efficacy of commercially available different antiseptic gels on Streptococcus
mutans and Lactobacillus acidophilus well-diffusion method was used. To assess the antibacterial efficacy after
incubation in appropriate culture medium diameter of zone of inhibition was measured.

Results:

Maximum zone of inhibition was found with Cure next gel (40 mm,40mm) followed by
Hexigel (30 mm, 21mm), Mucopain (17 mm, 17mm), and Dologel (7 mm, 16mm) against S. mutans
and L. acidophilus, respectively. Analysis of variance (ANOVA) and Post Hoc Test were used
to analyze results statistically. The difference between commercially available different dental gels
was statistically significant (P < 0.001) at a 5%.

Conclusion:

In the present study, it was seen that Curenext gel was more effective followed by Hexigel, Mucopain gel
and Dologel on S. Mutans and L. Acidophilus.
From the editor - September 2013
Authors: Young Angela
Published: November 2020

A letter from the editor.
Efectividad de enmiendas sobre el crecimiento y rendimiento de fréjol común en suelo andisol ácido
Authors: Cuenca-Tinoco Anabel Carmen , Castro-Delgado Noemi Isabel , Cargua-Chávez Jessica Elizabeth , Cedeño-García Galo Alexander , Cedeño-Zambrano José Luis
Published: November 2020

El objetivo de la investigación fue evaluar el efecto de varias enmiendas sobre el crecimiento y rendimiento del fréjol común en un suelo andisol ácido de la zona de Santo Domingo de los Tsáchilas, Ecuador. Los tratamientos evaluados fueron T1 (Humus +harina de rocas), T2 (Humus + dolomita), T3 (Compost +harina de rocas), T4 (Compost + dolomita), T5 (Gallinaza +harina de rocas), T6 (Gallinaza + dolomita), T7(Fertilización convencional) y T8 (Control). El diseñoutilizado fue de bloques completos al azar con tres repeticiones. Las principales variables registradas fueron peso seco de planta (g), rendimiento de grano (kg ha-1) y pH del suelo. Los tratamientos de enmiendas influenciaron significativamente (p<0,05) el peso seco de planta, el rendimiento de grano y el pH del suelo. Los tratamientos más efectivos fueron las combinaciones de dolomita + gallinaza, compost y humus, que incrementaron el crecimiento en términos de peso seco en 22, 27 y 31%, respectivamente, en relación al tratamiento control. El mayor incremento en rendimiento de granos también fue alcanzado con dolomita + gallinaza, compost y humus, con 21, 28 y 30%, respectivamente, en relación al tratamiento testigo. El pH del suelo fue elevado hasta 5,74; 5,76 y 5,85 con dolomita + gallinaza, compost y humus, respectivamente. La aplicación de enmiendas alcalinizantes debe ser una práctica común para potenciar crecimiento, rendimiento y respuesta a la fertilización del frejol común en suelos andisoles ácidos.
Building Health Services in a Rapidly Changing Landscape: Lessons in Adaptive Leadership and Pivots in a COVID-19 Remote Monitoring Program (Preprint)
Authors: Laur Celia Violet , Agarwal Payal , Mukerji Geetha , Goulbourne Elaine , Baranek Hayley , Pus Laura , Bhatia R Sacha , Martin Danielle , Bhattacharyya Onil
Published: November 2020

UNSTRUCTURED

Adaptive leadership has become an essential skill for leaders in health systems to respond to the COVID-19 pandemic as new knowledge emerges and case counts rise, fall, and rise again. This leadership approach has been described as an iterative process of taking a wide view of the situation, interpreting the meaning of incoming data from multiple directions, and taking real-time action. This process is also common in start-ups, which attempt to create new products or services of uncertain value for consumer markets that may not yet exist. Start-ups manage uncertainty through “pivots,” which can include changes in the target group, need, features, or intended benefit of a product or service. Pivots are large changes that account for the high likelihood of getting something wrong during development, and they are distinct from the “tweaks” or small tests of change that define quality improvement methodology. This case study describes three pivots in the launch of a remote monitoring program for COVID-19. Adaptive leadership helped inform strategic decisions, with pivots providing a framework for internal and external stakeholders to articulate options for changes to address shifting needs. There is considerable uncertainty in the appropriate design and implementation of health services, and although this case example focuses on the use of adaptive leadership and pivots during a pandemic, these strategies are relevant for health care leaders at any time.
Accurately Differentiating Between Patients With COVID-19, Patients With Other Viral Infections, and Healthy Individuals: Multimodal Late Fusion Learning Approach (Preprint)
Authors: Xu Ming , Ouyang Liu , Han Lei , Sun Kai , Yu Tingting , Li Qian , Tian Hua , Safarnejad Lida , Zhang Hengdong , Gao Yue , Bao Forrest Sheng , Chen Yuanfang , Robinson Patrick , Ge Yaorong , Zhu Baoli , Liu Jie , Chen Shi
Published: November 2020

BACKGROUND

Effectively identifying patients with COVID-19 using nonpolymerase chain reaction biomedical data is critical for achieving optimal clinical outcomes. Currently, there is a lack of comprehensive understanding in various biomedical features and appropriate analytical approaches for enabling the early detection and effective diagnosis of patients with COVID-19.

OBJECTIVE

We aimed to combine low-dimensional clinical and lab testing data, as well as high-dimensional computed tomography (CT) imaging data, to accurately differentiate between healthy individuals, patients with COVID-19, and patients with non-COVID viral pneumonia, especially at the early stage of infection.

METHODS

In this study, we recruited 214 patients with nonsevere COVID-19, 148 patients with severe COVID-19, 198 noninfected healthy participants, and 129 patients with non-COVID viral pneumonia. The participants’ clinical information (ie, 23 features), lab testing results (ie, 10 features), and CT scans upon admission were acquired and used as 3 input feature modalities. To enable the late fusion of multimodal features, we constructed a deep learning model to extract a 10-feature high-level representation of CT scans. We then developed 3 machine learning models (ie, k-nearest neighbor, random forest, and support vector machine models) based on the combined 43 features from all 3 modalities to differentiate between the following 4 classes: nonsevere, severe, healthy, and viral pneumonia.

RESULTS

Multimodal features provided substantial performance gain from the use of any single feature modality. All 3 machine learning models had high overall prediction accuracy (95.4%-97.7%) and high class-specific prediction accuracy (90.6%-99.9%).

CONCLUSIONS

Compared to the existing binary classification benchmarks that are often focused on single-feature modality, this study’s hybrid deep learning-machine learning framework provided a novel and effective breakthrough for clinical applications. Our findings, which come from a relatively large sample size, and analytical workflow will supplement and assist with clinical decision support for current COVID-19 diagnostic methods and other clinical applications with high-dimensional multimodal biomedical features.
EFEKTIVITAS PERANGKAT PEMBELAJARAN BERORIENTASI MODEL PROBLEM BASED LEARNINGBERMUATAN KARAKTER DITINJAU DARI HASIL BELAJAR PESERTA DIDIK
Authors: Afza Aulia
Published: November 2020

This research aims to produce learning materials oriented problem-based learning model contain character that effective from student learning outcomes aspect, affective, cognitive, and psychomotor. This is research with the Plom model.Research conductedfor student of XI MIAgradeof senior high school. The instrumentusedan observation sheet with 6 indicators, multiple choicewritten testas many as 25 items with high cognitive levelsandthe performance assessment. Data analysis uses the percentage formula. The research results obtained that the average value of affective learning outcomes is 83,44% (effective), the average value of cognitive learning outcomes is 81,13%(effective)and 87,5% of students have exceeded the minimum criteria. The average value of psychomotor learning outcomes is 89,6% (effective). Conclude that product development has been effective from the student learning outcomes aspect.
Ethnomedicinal Plants Used Against Diarrhea Available in Mizoram, Northeast India: A Systematic Review
Authors:   Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India, Zothantluanga James H. , Vanlalhriatpuii Catherine ,   Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India, Lalthanzara H. ,   Department of Zoology, Pachhunga University College, Aizawl, Mizoram, India, Lalhlenmawia H. ,   Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences, Aizawl, Mizoram, India, Bhat Hans Raj , Shakya Anshul ,   Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India
Published: November 2020

Diarrhea is the frequent passing of watery stools not less than three times per day and may occur due to unhygienic lifestyle or infection. Diarrhea kills approximately 1.4 million people annually and is the 9th and 6th leading cause of death at a global level and India respectively. The therapy for diarrhea includes antibiotics and other agents, including a number of medicinal plants at global level. India, in particular northeast, is rich in medicinal plants and various Indian systems of medicine make use of these diverse flora. Mizoram lies within the Indo-Myanmar biodiversity hotspot and is blessed with a rich floral diversity. Though there are a number of available published literatures on medicinal plants that are used for various purposes, there is a lack of research information regarding the traditional medicinal plants used against diarrhea. The extent of the status of the research work carried out on medicinal plants used against diarrhea is still uncertain. Therefore this paper aims to systematically highlight the quantity, status of research work, and the scope for future research with medicinal plants available in Mizoram having ameliorative property against diarrhea. The literature survey revealed a total of 68 traditionally used medicinal plants available in Mizoram with a remedial property for diarrhea wherein 24 of these had been subjected to scientific evaluation. This paper provides a comprehensive compilation about the available ethnomedicinal plants that would facilitate in the search for newer and safer antidiarrheal therapeutic lead(s) and standardization of herbal medicine(s).
Elastic Waves in the Half-space of an Incompressible Thermoelastic Material with Transverse Isotropy
Authors:   Department of Education, Assam University, Silchar-788 011, Assam, India, Zorammuana C. , Tochhawng Lalawmpuia ,   Department of Mathematics & Computer Science, Mizoram University, Aizawl–796 004, Mizoram, India, Singh S.S. ,   Department of Mathematics & Computer Science, Mizoram University, Aizawl–796 004, Mizoram, India
Published: November 2020

This paper investigates the problem of incident and reflected shear waves in an incompressible thermoelastic material having transversely isotropic property using Lord-Shulman theory on generalized thermoelasticity. Two plane shear waves are shown to exist in such medium and the expressions for non-dimensional velocities are given. The amplitude ratios of the reflected waves caused by the incident wave at the stress free surface have been derived by taking suitable boundary conditions. The effect of specific heat and material constants on the amplitude ratios has been analysed numerically and the results are presented graphically.
Hombres cosechadores del bosque pluvial bajo del Chocó, estudio paleoetnobotánico
Authors: Romero Picón Yuri
Published: November 2020

En el marco del Programa de Investigaciones Ecológicas iniciado por el INCIVA en la costa pacífica del Valle del Cauca, este estudio paleoetnobotánico aporta datos para ayudar a reconstruir la dieta de las poblaciones prehispánicas asentadas en la llanura aluvial de los ríos Calima y San Juan, mediante la identificación y el análisis de restos de frutos y semillas recuperados en contextos arqueológicos El estudio propone un modo de utilización de los recursos en el que las palmeras y los frutales, junto con el cultivo del maíz, constituyeron la principal fuente de alimentación vegetal entre el siglo II a.C. y el siglo XVII d.C.
Facioscapulohumeral Muscular Dystrophy Can Be a Cause of Isolated Childhood Cognitive Dysfunction
Authors: Hobson-Webb Lisa D.
Published: November 2020

Facioscapulohumeral muscular dystrophy is one of the most prevalent muscular dystrophies in the world, resulting from the deletion of tandem repeats on chromosome 4q35. Extramuscular associations include sensorineural hearing loss, mental retardation, and epilepsy. These manifestations are commonly found in those with large deletions and early onset of weakness. A 26-year-old patient with a long-standing history of hearing loss, learning disabilities, and epilepsy presented with new-onset weakness and an elevated serum creatinine kinase level. Genetic testing confirmed sporadic facioscapulohumeral muscular dystrophy with a fragment length of 12 kilobases (normal > 35 kilobases). This unique presentation suggests that facioscapulohumeral muscular dystrophy should be considered in the differential diagnosis of children with cognitive impairment, seizures, and hearing loss. ( J Child Neurol 2006;21:252—253; DOI 10.2310/7010.2006.00054).
HUBUNGAN DERAJAT QUADRICEPS ANGLE DENGAN PATELLA FEMORAL PAIN
Authors: Naufal Adnan Faris , Khasanah Dini Afriani , Noviyana Ulfa
Published: November 2020

Petellofemoral pain syndrome (PFPS) tidak memiliki definisi yang jelas tentang bagaimana gejala dan letak nyeri yang dirasakan seseorang yang mengalaminya. Diketahui PFPS memiliki hubungan terhadap besar sudut otot quadriceps atau Q angle. Namun masalahnya masih belum spesifik berapa besar Q-angle yang memiliki resiko terhadap PFPS. Penelitian ini dimaksudkan untuk mencari tahu hubungan antara besar q-angle dengan resiko PFPS. Untuk mngetahui adanya PFPS dapat dilakuka dengan Clarke's test, sedangkan untuk mengukur besar sudut Q-angle diukur dengan goniometer. Subyek penelitian mengambil dari pemain basket Universitas Muhammadiyah Surakarta. Data yang dikumpulkan kemudian dianalisis menggunakan uji Spearman Rho. Hasil penelitian menunjukan adanya hubungan Q-angle dan patellafemoral pain syndrome pada pemain bola basket wanita. Nilai p value dari Q-angle sebesar 0,024 sehingga Ho ditolak dengan nilai r = 0,579 menunjukan hubungan positif dan kekuatan korelasi yang tinggi, patellofemoral pain syndrome 0,043 dengan nilai r = 0,528 menunjukan hubungan positif dan kekuatan korelasi yang kuat. Hasil penelitian ini menunjukkan terdapat hubungan Q-angle terhadap keluhan patellofemoral pain syndrome.
Estimation and Evaulation of Collagen Fibres as Stromal Componment in Various Grades of Oral Squamous Cell Carcinoma Using Picrosirius Red Stain under Polarised Microscope
Authors: Nayak Manjushree , Panda Jayanta Kumar , Mishra Sudha Smruti , Das Bijay Kumar
Published: November 2020

Oral squamous cell carcinoma (OSSC) is the 3rd most common form of malignancy in developed countries[1]. The tumour is composed of two basic components i e, the neoplastic cells and the reactive stroma. The stromal changes which indicate the propensity of tumour cells to infiltrate and metastasise can also be used as one of the prognostic indicator[4,5]. Use of Picrosirius red (PSR) stain along with circular polarising microscope is helpful to detect spread of malignancy and guides the treatment plan and assess prognosis[11]. The present study is aimed to analyse the various aspects of collagen fibres in relation with the different grades OSSC. 30 patients of OSCC of various grades and 10 cases of normal mucosa were evaluated and data analysed statistically using sigma scan pro image analysis software(SPSS).

Observation: Thirty patients (male-19 and female -11) of OSCC of age group 47-60 years were analysed. There were 14 well differentiated (WDSCC), 12 moderately differentiated (MDSCC) and 4 poorly differentiated (PDSCC) cases. When examined under polarising microscope majority (85.7%) of WDSCC and 41.67% of MDSCC showed reddish orange (RO) collagen fibres whereas in PDSCC (50%) showed green yellow (GY) collagen fibres which is statistically significant (P=0.02).In WDSCC 57.14% and in MDSCC 50% had swirl(S) arrangement whereas in PDSCC 50% had crosss hatchet (CH) and bundle arrangement. This is again statistically significant (P=0.031).While examining the orientation of collagen fibres in WDSCC 71.43% and in MDSCC, 83.33% had parallel orientation whereas in PDSCC 75% showed non parallel orientation. This orientation is statistically significant (p.008). On comparing the nature of birefringence maximum cases of WDSCC (85.71%) and MDSCC (83.33%) revealed strong birefringence whereas in PDSCC 75% exhibited weak. (statistically significant p.001).

Conclusion: PSR stain under polarising microscope is an adjunct to the routine staining for studying stromal changes. The colour, arrangement, orientation & birefringence changes reflect its gradual shift from WDSCC to PDSCC and may help as a diagnostic and prognostic tool in OSCC.
The Management of Local Wisdom Tourism of Baduy Tribe by Department of Tourism of Lebak Regency, Banten, Indonesia in Increasing the Number of Tourists
Authors: Umarella Farid Hamid , Tanty Dewi Sad , Anjanie Aprezia
Published: November 2020

The Baduy Village is one of the tourist destinations located in Lebak Regency, Banten, Indonesia. The Department of Tourism of Lebak Regency manages the tourism potential of the Baduy tribe which is loaded with the local wisdom besides its natural beauty.

This study aimed to analyze the management of local wisdom tourism of Baduy tribe by the Department of Tourism of Lebak Regency Banten, Indonesia in increasing the number of tourists.

A constructivist paradigm with a case study method was used in this study. The informants were from the Department of Tourism of Lebak Regency and tourists who have been to the Baduy Village. The data collection was done through structured interviews, observations and literature studies. The qualitative data analysis technique was carried out to reveal the tourism management. The research results showed that the tourism management through promotion strategies used segmentation, targetting, and positioning approaches based on geographic, psychographic, and demographic. It also used the promotional media
Desarmar(se) varón - construir(se)padre: intervenciones psicoanalíticas con jóvenes varones en contexto de encierro punitivo
Authors: Colanzi Irma
Published: November 2020

A partir de los desarrollos de los estudios de género, las masculinidades y la teoría cuir problematizaremos, en primer lugar, cómo el psicoanálisis explica al sujeto en vínculo con las concepciones culturales de masculinidad y feminidad. En segundo lugar, analizaremos cuáles son las intervenciones clínicas posibles en la cárcel. Al momento de reflexionar sobre nuestras herramientas como psicoanalistas, se analizarán las lógicas de producción de un dispositivo terapéutico en una unidad penitenciaria atendiendo a dos especificidades: las lógicas del encierro punitivo y los lazos sexo-afectivos de los jóvenes varones privados de libertad. Partiremos de la noción de intervención, que atendiendo a estas particularidades, y entendiendo la ética psicoanalítica orientada a la subversión del sujetx, se ve mutilada al no incluir las categorías de análisis y praxis de los estudios de género.
Las que ciñen, pero no oprimen
Authors: Veneziano Mariana
Published: November 2020

El presente trabajo reúne tres películas para impresión destinadas a publicitar la marca Ducilo, producidas por Ángela Vassallo en su paso por Cícero Publicidad desde el año 1969 hasta el 1978. Actualmente resguardadas por la Fundación IDA, las piezas abren nuevas formas de lectura atravesadas por los estudios visuales y de género. Dentro del circuito del consumo y la exhibición de productos, las nociones de erotismo y de emancipación aparecen y desaparecen y, de esta manera, desmantelan la construcción del ser-mujer. A partir de la revisión de las prácticas de representación, se manifestarán en el análisis los matices entre el diseño y la pieza artística, y el refuerzo y la ruptura en la configuración visual de lo femenino.
Te llamaré fea
Authors: Battaglino Paula , Lavandera Marcela , Pereyra Romina , Tournie Yamile
Published: November 2020

El presente trabajo tiene como objetivo analizar una serie de documentos que se integran bajo la temática mujeres barbudas, pertenecientes al Archivo de Redacción del diario Crónica. Compuesta por fotografías y por recortes periodísticos, esta selección en particular pretende dar cuenta de cómo se construye la otredad en el imaginario popular. En nuestro caso, nos referiremos al uso de imágenes de mujeres con hirsutismo que fueron catalogadas como fenómenos ante los ojos de la sociedad.