bluuebunny/crossref_metadata_2025 huggingface dataset:
“Nano-Herbal Innovations: Precision In Therapeutic Delivery”
Authors: Shah Niyati , Kumari Mamta , Sadhu Piyushkumar , Talele Chitrali , Rajput Hemraj Singh , Sapra Ritu
Published: January 2024

Herbal nanoparticles, an innovative fusion of traditional herbal medicine and modern nanotechnology, represent a burgeoning field with vast therapeutic potential. These nanoparticles are crafted by employing various techniques like green synthesis, coacervation, or ionic gelation, utilizing natural substances derived from plants. The encapsulation of herbal extracts within nanoparticles enhances their bioavailability, stability, and targeted delivery, addressing longstanding limitations of traditional herbal medicine. The miniature size of these nanoparticles allows for easy penetration into cells, tissues, and even across physiological barriers, thereby augmenting their efficacy. Moreover, herbal nanoparticles exhibit remarkable versatility in treating diverse health conditions. Their antioxidant, anti-inflammatory, antimicrobial, and anticancer properties have been extensively studied and documented. By encapsulating compounds derived from plants, such as curcumin, resveratrol, or quercetin, within nanoparticles, their therapeutic effects are amplified manifold, fostering promising avenues for combating various diseases. Nano-sized herbal formulations shows reduced toxicity compared to their conventional ones, owing to controlled release profiles and targeted action. They hold great promise in personalized medicine, allowing for tailored therapies based on individual patient requirements. However, despite their immense potential, challenges persist in terms of large-scale production, standardization, and regulatory aspects. Further research is warranted to show their long-term safety profile and optimize their efficacy for widespread clinical applications.In conclusion, herbal nanoparticles represent a remarkable convergence of traditional herbal wisdom and cutting-edge nanotechnology. Their remarkable properties pave the way for groundbreaking advancements in healthcare, offering novel solutions for prevalent diseases while honoring the rich heritage of natural remedies. Continued exploration and refinement of these nanoparticles hold the key to unlocking their full therapeutic potential.
Characterization Of Probiotic Lactic Acid Bacteria From Honey And Assessment Of Their Effects On Consumption By Type-2- Diabetes Using Wistar Rat
Authors: A Akhila , Kumar Anil , Gupta Vinay Kumar , Shah Darshan Vinod , Karan Rohan Kumar , Anant Anju , Ghosh Tanmay , Sarma Satyabrat , E Keshamma
Published: January 2024

The relevance of probiotic, especially lactic acid bacteria cannot be over emphasized. In this present study three honey sources were serially diluted and cultured on De Man, Rogosa and Sharpe (MRS) agar among which only one of this sources grew on MRS agar. The pure Lactobacilli isolate were subjected to gram staining, biochemical tests, physiological test, molecular analysis using Polymerase Chain Reaction (PCR) techniques and Deoxyribonucleotide (DNA) sequencing. Only one isolate was obtained known as Enterococcus fecalis. The isolate was subjected to probiotic selection and was found fit for consumption, however their effect when consumed by type-2 diabetic are alarming and based on the outcome of this study, diabetic patient are advised not consume honey.
Potential Of Stem Cell Therapy
Authors: Khicher Rimple , Chauhan Niharika , Sarita  , Asha  , Kumar Satish
Published: January 2024

The study of stem cell therapy has led to the development of a very advanced, promising, and effective method for conducting scientific research. This success has ushered in a new era of treatment through various paths of dividing patterns. After the regeneration of stem cells, different lab procedures are used to cultivate distinct cell types. Quality control and teratoma development assays are among the methods used to evaluate the growth kinetic characteristics of the stem cells. To determine the best natural-type environmental conditions for a certain differentiation, various culture mediums are tested. Extracellular vesicle-based therapies and graphene scaffolds, which have enormous therapeutic potential due to their adaptability, are some of the structures used. This review focuses on the discovery of many stem cells and their potential for therapeutic use in modern medicine. The wide range of stem cell functions creates a very effective technique that offers an alternative for disorders that cannot be cured. The objective of the review is to draw attention to the stem cell treatment system among researchers.
Therapeutic options in a patient with highly aggressive multiple sclerosis and genetic predisposition to autoimmune process: a clinical case
Authors: Baidina T. V. , Trushnikova T. N. , Danchenko I. Yu.
Published: January 2024

A clinical case of highly aggressive multiple sclerosis in a patient with a family history of demyelinating disease is presented. The effectiveness of early pathogenetic therapy by blocking the adhesion molecules of lymphocytes is demonstrated.
Reviewing the pages of the first issues of «Perm medical journal»: 100th anniversary of this authoritative russian scientific edition
Authors: Davidov М. .I
Published: January 2024

In 2023, we celebrate a historical date – the 100th anniversary of publishing the first issue of “Perm Medical Journal”. The first editor-in-chief was an outstanding doctor, the founder of the first surgical school, Professor V.N. Parin. The content of the first eight volumes of the journal issued from 1923 to 1930 is analyzed in the article. The first paper of the first issue of a journal was devoted to epidemic typhus and relapsing fever. The papers of great scientists, professors such as A.V. Pshenichnov, P.I. Pichugin, A.S. Lebedev, P.I. Chistyakov, V.P. Pervushin and others impress by profundity of thought. Great attention in the journal was paid to the questions of surgery and urology; these papers constituted 52% of the content of the first eight volumes. Analysis of the works belonging to V.N. Parin, D.P. Kuznetsky, V.P. Shipitsyn, B.Ya. Strelkov, A.A. Vechtomov and other authors, which were devoted to diagnostics, treatment and prevention of gastric ulcer, ventral hernias, tumors of different organs, inflammatory surgical diseases, vascular, urinary, urethral and genital injuries, rhinoplasty, show that these publications aroused interest among Russian and foreign scientists and physicians and significantly influenced a progress of medical science and practical health care.
Simulation training in medicine: past, present and future
Authors: Baidarov А. А. , Vronsky А. S. , Lazarkov P. V. , Astashina N. B. , Shamarina А. М.
Published: January 2024

The research was carried out with financial support of Perm Scientific and Educational Center "Rational Subsoil Use" (2023), the project "New materials and technologies for medicine".
The article provides a review of literature on the use of simulation learning in medical education. The review used articles on simulation in training at the specialty, residency and continuing postgraduate medical education levels. The research has demonstrated that simulation training leads to improved performance among future physicians. Simulation in the learning process allows improving teamwork and communication. With the introduction of medical accreditation and opening of simulation centers at medical universities throughout the country, simulation training is a basic principle of medical education in the Russian Federation. As medical simulation becomes more common, there is a need to develop new methods providing increase in effectiveness of training specialists including medical staff of the highest qualification.
Acciones colectivas para la construcción de paz con perspectiva interseccional. El caso de la Asociación de Mujeres Afrodescendientes de Yolombó (ASOMUAFROYO)
Authors: Triviño-Monar Manuela
Published: January 2024

Afro-descendant communities, especially ethnically differentiated women, have been victims of the historical neglect of the Colombian State. They have suffered the systematic violation of their fundamental rights due to social inequality, discrimination and the violence caused by the Colombian armed conflict. The objective of this article is to analyze, through a qualitative methodology, the organizational experience and collective actions for peace taken by the Association of Afro-descendant Women from Yolombó (ASOMUAFROYO), North Cauca. An intersectional perspective based on the categories of race/ethnicity, gender, and class as key points that structure peacebuilding initiatives is adopted. As a result, it was found that the definition of peace is linked to territory and ancestry, and that collective actions focus on meeting the needs of the community and make up for the historical shortcomings of the Colombian state in their territory.
Natural treasures from Picrorhiza kurrooa: a computational exploration of drug-like properties and bioactivity of kutkin, cucurbitacin, apocynin and lupanine
Authors: Britto G. Francis , Subash K. R. , Nagamani N.
Published: January 2024

Background: To analyse and predict the basic pharmacokinetic and toxicological properties of four compounds of interest found in Picrorhiza kurroa (Kutkin, cucurbitacin, apocynin and lupanine) using computational bioinformatics tools.
Methods: The chemical structures and molecular properties of the compounds were obtained from authentic sources and processed for data profiling. 2D structures were converted to 3D structures using ChemSketch software and PHASE module. In silico screening of the 3D structures was performed using bioinformatics prediction software to assess drug-likeness, absorption, blood-brain barrier penetration, enzyme interaction potential, skin penetration, and acute oral toxicity.
Results: Kutkin exhibited poor drug-likeness and low oral absorption, while the other three compounds showed promising drug-like properties and good oral absorption. Cucurbitacin and lupanine were predicted to cross the blood-brain barrier, while Kutkin and Apocynin were not. None of the compounds were substrates for P-glycoprotein, but Kutkin and cucurbitacin were substrates for CYP3A4. All four compounds had low skin penetration. Acute oral toxicity varied, with cucurbitacin classified as highly toxic and the others as slightly toxic.
Conclusions: Cucurbitacin, apocynin, and lupanine have potential for further development as therapeutic agents due to their favorable drug-like properties and good absorption. Kutkin's poor drug-likeness and low absorption make it less suitable for oral drug development. This information provides valuable insights for further research on the medicinal properties of Picrorhiza kurroa and the development of new drugs based on its active compounds.
A study of urinary tract infection in pregnancy and its effect on maternal and perinatal outcome
Authors: Kerure Rajshekhar D. , Biradar Amaresh V. , Lakshetty Swetha , Biradar Sudha
Published: January 2024

Background: Urinary tract infection (UTI) during pregnancy is very common in developing countries like India. UTI is caused by the growth of micro-organisms in the urinary tract. This study aims to determine the incidence of UTI in whole pregnancy and its adverse effects on mother and fetus.
Methods: This is a prospective study conducted in outpatient department of ESIC medical college for one year from January 2017 to December 2017. A total of 182 pregnant women attending OBG OPD for ANC check-up without any medical disorders or previous adverse pregnancy outcomes of 18-35 years of age were included in the study. Urine routine and urine culture sensitivity were done for all.
Results: Out of 182 pregnant women tested for UTI, the incidence of UTI in pregnancy was found to be 19%. Asymptomatic UTI was noted in 65% patients with UTI. Primigravida were commonly affected (56%). Highest cases were in 18 to 25 years (63%) age group. 56% cases showed 6-10 pus cells/HPF. Prevalence of UTI was more common in winter seasons. Commonest causative organism was E. coli in 38% cases. Maternal complications like anaemia (26%) and puerperal pyrexia (23%) were observed. Adverse fetal outcomes like preterm birth (35%) and fetal growth restriction (15%) were observed.
Conclusions: In this study, the prevalence rate of UTI during pregnancy is high (19%). The physiological changes of pregnancy predispose the women to UTI so does the other factors such as age, sexual activity, hygiene, multiparty, previous history of UTI and socio-economic conditions. All pregnant women should be screened for UTI with a urine routine and urine culture, treated with antibiotics if the culture is positive and then retested for cure. Awareness has to be created about good hygienic practices and adequate hydration among pregnant women.
ADR assessment of isoniazid induced psychosis: Case report and review of literature
Authors: Kurup Karan Krishna , Shamabanu KP , Khadeejathul Nifana Nasrin NK , Hafshath MM , Karim Muhammed Sinan Abdul
Published: January 2024

Tuberculosis ranks among the top 10 causes of death globally and stands as the primary cause attributed to a single infectious agent. Among all antitubercular drugs, Isoniazid is most important role in the management of pulmonary tuberculosis.Various neuropsychiatric adverse effects have been documented in association with the use of isoniazid, both in therapeutic and overdose scenarios. This case report describes a 68-year-old male with multiple health issues, including disseminated tuberculosis, developed drug-induced psychosis, likely due to isoniazid in his anti-tubercular therapy. This case underscores the challenges of psychiatric adverse effects in tuberculosis treatment and emphasizes the importance of prompt recognition and intervention.
Konflikt roli rodzicielskiej z rolą chorej doświadczany przez kobiety mierzące się z chorobą nowotworową
Authors: Mazurek Emilia
Published: January 2024

Pełnienie roli społecznej wiąże się z respektowaniem pewnego systemu zachowań według określonego wzoru postępowania zgodnego z oczekiwaniami społecznymi. Choć możliwa jest pewna dowolność w zakresie pełnienia roli społecznej, to jednak przekroczenie ustalonych granic może wiązać się z doświadczeniem przez człowieka negatywnych sankcji społecznych, a nawet prawnych. Rola rodzicielska jest jedną z wielu ról społecznych, którą człowiek może pełnić w swoim życiu. Charakterystyczne jest jej splątanie z innymi rolami społecznymi. Konsekwencją nakładania się kilku ról może być ich konflikt. Dzieje się tak w sytuacji doświadczenia przewlekłej choroby somatycznej przez jednego z rodziców. Kobieta dotknięta chorobą onkologiczną zaczyna pełnić rolę chorej, co uniemożliwia, utrudnia lub modyfikuje sposoby pełnienia dotychczasowych ról społecznych (w tym rodzicielskiej) i wymusza podjęcie nowych. Konflikt roli rodzicielskiej z rolą chorej dotyczy wielu obszarów, a jednocześnie obliguje matkę i pozostałych członków rodziny do wypracowania strategii radzenia sobie. Zgodnie z Kartą Praw Rodziny członkowie rodziny mają prawo spodziewać się, że społeczeństwo i odpowiednie instytucje zapewnią im pomoc w nadzwyczajnych wypadkach (tu: w chorobie). Celem artykułu jest przedstawienie wybranych płaszczyzn konfliktu roli rodzicielskiej z rolą chorej w sytuacji doświadczania przez matkę choroby nowotworowej oraz charakterystyka wybranych implikacji podjętego problemu dla praktyki pedagogicznej.
Komunikaty rodzicielskie w kontekście samooceny nastolatków
Authors: Gruca-Miąsik Urszula
Published: January 2024

Proces prawidłowego i pełnego rozwoju adolescenta warunkowany jest w dużej mierze kompetencjami wychowawczymi jego rodziców. Wśród tych kompetencji niezwykle istotną rolę odgrywają umiejętności komunikacyjne rodziców, którzy mogą stymulować osiągnięcie przez młodego człowieka dojrzałej osobowości, bądź go destruować. Nie ulega przy tym żadnej wątpliwości, że komunikaty rodzicielskie kierowane do młodych ludzi w sposób szczególny warunkują właściwą samoocenę adolescentów. Celem artykułu jest wykazanie, że zarówno na poziomie teoretycznych analiz, jak i empirycznych badań, uwidacznia się wyraźna korelacja pomiędzy jakością komunikatów rodzicielskich a dojrzałą samooceną młodych ludzi. Świadomość wagi tej kwestii winna więc zarówno rodziców, jak i wszystkich zajmujących się rodziną, skłaniać do większego zainteresowania się zagadnieniem pożądanego stylu komunikowania się w obrębie rodziny.
Exploring the monogamy principle in the Samin community’s customary marriages in Kudus: Harmonisation of tradition and state law
Authors: Iman Iman Fadhilah , Tedi Kholiludin  , Muhammad Lutfi Hakim  , Ubbadul Adzkiya'
Published: January 2024

This article explores the practice of monogamy in customary marriage within the Samin community in Larikrejo Village, Kudus, rooted in the principle of “bojo siji kangge saklawase”. The uniqueness of this customary marriage practice is evident in the reflection of the values of Samin society, passed down through generations by their ancestors. Its significance becomes more pronounced considering the prevalence of polygamous practices in customary marriages across various regions of Indonesia. Despite the allowance of polygamy within certain limits by state law, the Samin community chooses to uphold their customary marriage traditions. This article presents the findings of field research involving four key informants and direct observations of customary marriage practices as the primary source. The research reveals that the practice of monogamy within Samin community marriages reflects the embodiment of the “bojo siji kangge saklawase” principle, manifested through a solemn pledge to one wife made by prospective grooms during the paseksen stage, the final step in the customary marriage ceremony following nyumuk (betrothal) and pasuwitan (marriage contract). The obligation to make this pledge aims to prevent potential conflicts within Samin families. This monogamous practice aligns with the principles of monogamy and the objectives of marriage in state law, creating harmony and stability within the family institution. This study provides in-depth insights into the unique relationship between local values and state regulations amidst the challenges of modernization and ongoing social changes.
Restoring an Extremely Destructed Tooth with Flared Root Canal Walls: A Case Report
Authors: Kermanshah Hamid , Estedlal Taraneh
Published: January 2024

Reconstructing severely damaged teeth has always presented a challenge when the remaining crown structure is limited, often requiring retention from the root canal using intracanal posts. However, the real challenge is when the root canal walls are also weak, and there is a high risk of vertical root fracture due to the wedging forces of a rigid post. This case report presents a tooth with extremely flared (0.3mm) root canal walls, successfully restored with a newly introduced polymer made of polyether ether ketone (PEEK), with one-year follow-up. Due to its close elastic modulus to dentin, capacity to bond effectively to tooth structure, shock-absorbing properties, and thereby facilitating favorable stress distribution, utilizing this material for an intracanal post has the potential to mitigate the risk of fractures often associated with cast metal posts. It combines the good fitness of cast posts with the low modulus of elasticity and optical properties of prefabricated fiber posts.
Plasma Circulating Terminal Differentiation–Induced Non-Coding RNA Serves as a Biomarker in Breast Cancer
Authors: Torkdari Zeynab Shaghaghi , Khalaj-Kondori Mohammad , Hosseinpour Feizi Mohammad Ali
Published: January 2024

Background: Breast cancer is identified as the most common malignancy and cause of cancer-related death worldwide. Compared with healthy controls, this study evaluated the expression level and diagnostic power of lncRNA plasma TINCR in breast cancer patients.
Materials and Methods: Fifty-eight women diagnosed with invasive ductal carcinoma and fifty healthy age- matched controls were included in the study. TRIzol® LS regent was used to isolate the total RNA from the whole plasma. Total RNA was converted to cDNA using Prime ScriptTM RT reagent kit and the expression levels of TINCR were quantified by qRT-PCR.
Results: Low levels of TINCR lncRNA were observed in the plasma of breast cancer patients compared with control subjects. Plasma TINCR level was also positively correlated with the diagnostic age of breast cancer patients.
Conclusion: A low level of plasma TINCR could discriminate breast cancer patients from healthy control subjects.
Kinetics of Recovery of Naïve and Memory T Cells in Acute Leukemia Patients after Allogeneic Stem Cell Transplantation Depending on Different GVHD Prophylaxis Regimens
Authors: Popova Natalia , Drokov Mikhail , Davydova Yulia , Kapranov Nikolay , Vasilieva Vera , Galtseva Irina , Kuzmina Larisa , Parovichnikova Elena
Published: January 2024

Background: Memory T cells are a heterogeneous population of immune cells that provide adaptive immunity. Its full recovery seems essential for graft-versus-tumor reactions that provide an opportunity for biological cure in patients with acute leukemia. The use of mismatched or haploidentical donors has increased, which has become possible because of modifications in graft versus host disease (GVHD) prophylaxis.
Materials and Methods: Sixty-five leukemia patients (acute myeloid leukemia – 40, acute lymphoblastic leukemia – 25), median age 33 (17–61) years, underwent allo-HSCT from 2016 to 2019 in the National Research Centre for Hematology. Patients were divided into three groups based on the impact of GVHD prophylaxis on T cell recovery: horse antithymocyte globulin (ATG)-based regimen (n=32), horse ATG combined with posttransplant cyclophosphamide (PT-Cy) (n=18), and ex vivo T cell depletion (n=15).
Results: The early period after transplantation (before day +100) was characterized by significantly lower absolute numbers of T naïve, memory stem and T central memory cells in peripheral blood in patients after ATG+PT-Cy-regimen or ex vivo T cell depletion than after ATG-based prophylaxis (p<0.05). Moreover, strong depletion of naïve T and memory stem cells prevents the development of GVHD, and determining the absolute number of CD8+ naïve T and memory stem cells with a cutoff of 1.31 cells per microliter seems to be a perspective in assessing the risks of developing acute GVHD (p=0.008). The dynamics of T cell recovery showed the involvement of either circulating or bone marrow resident T effector cells shortly after allogeneic transplantation in all patients, but the use of manipulated grafts with ex vivo T cell depletion requires the involvement of naïve and memory stem cells. There was no significant effect of T cell recovery on leukemia relapse after allogeneic transplantation.
Conclusion: These experimental outcomes contribute to providing the best understanding of immunological events that occur early after transplantation and help in the rational choice of GVHD prophylaxis in patients who will undergo allogeneic transplantation. Our study demonstrated the comparable immunological effects of posttransplant cyclophosphamide and ex vivo T cell depletion and immunological inefficiency of horse ATG for GVHD prevention.
Results of Autologous Hematopoietic Stem Cell Transplantation in Patients with Multiple Myeloma (MM) and Renal Impairment: A Retrospective Single-Center Study
Authors: Soloveva Maiia , Solovev Maxim , Mironova Daria , Mendeleeva Larisa
Published: January 2024

Background: To assess the efficacy of autologous hematopoietic stem cell transplantation (auto-HSCT) in multiple myeloma (MM) patients with acute renal failure.
Materials and Methods: A retrospective single-center study included 64 patients (30 men, 34 women) with MM and kidney damage at the onset of the disease, aged 19 to 65 years (median 54), who underwent auto-HSCT from 2013 to 2019. 23 patients (36%) were dialysis-dependent at the time of diagnosis. The analysis was carried out in two groups: the "HD-" group (patients who were independent of hemodialysis during auto-HSCT, n = 54), and the "HD +" group (patients who underwent auto-HSCT while treated with programmed hemodialysis, n = 10). Research results were statistically processed using the Statistica software (version 10.0); the data obtained were presented graphically. Statistical analysis was performed using survival analysis (using the Kaplan-Meier method, with a Log-Rank Test) and frequency analysis (using contingency tables and Fisher's test).
Results: The patients dependent on hemodialysis were significantly more likely to require red blood cell transfusions compared to the dialysis-independent patients (100% versus 35%, p = 0.0001). Reactivation of a herpes viral infection and reversible toxic encephalopathy developed significantly more often in the patients from the “HD +” group compared with the patients from the “HD-” group (30% versus 6%, p = 0.04 and 20% versus 0%, p = 0.02, respectively). As a result of the treatment (induction + auto-HSCT), 14 patients (61%) became hemodialysis-independent. There was no transplant-related mortality. With a median follow-up of 48 months, the 5-year overall survival (OS) and progression-free survival (PFS) were 70% and 42%, respectively.
Conclusion: Auto-HSCT is a safe and effective treatment for patients with MM complicated by acute kidney injury. Fourteen of 23 (61%) patients became dialysis-independent.
The Importance of Pseudo Thrombocytopenia Due to Platelet Cold Agglutination before Surgery, What Should We Do? A Case Report
Authors: Ghorbani Mohammad , Solouki Amin , Soltani Farhang , Moayedpour Amir , Khoshnegah Zahra
Published: January 2024

Platelet cold agglutination (PCA) is a rare in-vitro phenomenon caused by Immunoglobulin M (IgM) autoantibodies, which results in Ethylenediaminetetraacetic Acid (EDTA) independent pseudo thrombocytopenia (PTCP). Its diagnosis is made based on the peripheral blood smear (PBS) examination and pre-test warming blood sample.
Here, a case of PTCP secondary to PCA is presented. He was first admitted for pre-surgical tests but his platelet count was low. His blood was taken with EDTA and sodium citrate anticoagulant to rule pre-analytical error out. Then his sample warmed up and the test was run again with Mindray BC-6000 automated cell counter. Moreover, the rheumatologic tests were done for him.
His platelet count was 23×109/L at first, and PBS showed many platelet aggregates. The low platelet count was not correct with Sodium Citrate or re-sampling with EDTA so platelet satellitism and improper sampling were ruled out. By warming the sample up to 37⸰C, the Platelet count rose to 216×109 / L.  The rheumatologic tests were negative except for HLA-B27 which was positive.
Finally, he was diagnosed with PCA which is due to a cold antibody (clinically insignificant). This diagnosis is important for the prevention of recurrent tests, unnecessary platelet transfusion, and other problems. Here these conditions will be discussed.
Fludarabine-Based Reduced-Intensity Conditioning Regimen for Hematopoietic Stem Cell Transplantation in a Pediatric Patient with Sickle Cell Disease: A Case Report
Authors: Builes Natalia
Published: January 2024

Reduced-intensity conditioning (RIC) regimens have the potential to decrease toxicities related to hematopoietic stem cell transplantation (HCT) in patients with sickle cell disease (SCD). While initial results may have been acceptable in adults and young adults, there are no well-established strategies in children with SCD. Here, it is described the clinical course of two children with symptomatic SCD who have successfully undergone HSCT using Fludarabin-based conditioning.
Alteraciones de la salud humana por artefactos explosivos improvisados. Revisión sistemática exploratoria
Authors: Parra-Castañeda Angie Lizeth , Orjuela-Candela Laura Andrea , Daza Corba Jeritza Catalina , Moreno Arévalo Natalia , Urrego-Mendoza Zulma Consuelo
Published: January 2024

Objetivo: revisar la literatura existente indagando por los tipos de lesión o enfermedad que se han identificado en supervivientes de artefactos explosivos improvisados (AEI), así como aspectos individuales y colectivos relacionados con la protección o destrucción de la salud humana enfrentada a los AEI. Metodología: revisión sistemática exploratoria de literatura publicada en bases de datos, como PubMed, SciELO, LILACS, JSTOR, OpenGrey y Google Scholar, entre 2001 a 2021 en cualquier localización geográfica. Se incluyeron artículos de investigación, de revisión o reflexión, libros o capítulos de libro de investigación e informes técnicos, en inglés, español, francés y portugués. Resultados: cumplieron con los criterios de inclusión y fueron revisados 76 documentos. Se han reportado múltiples lesiones asociadas al uso de los AEI, sin que exista un patrón característico de lesión o enfermedad; no obstante, la lesión más común es la amputación bilateral de miembros inferiores. En supervivientes se ha encontrado que el personal militar afectado suele mostrar una mayor capacidad de resiliencia, calidad de vida, tratamiento oportuno y capacidad física funcional más alta, comparado con civiles. El apoyo social genera efectos positivos en la salud y bienestar de los afectados. Conclusiones: los AEI generan múltiples afectaciones a la salud humana, físicas y psicosociales, los cuales requieren una atención integral y multidisciplinaria para el tratamiento, rehabilitación y reintegración de los supervivientes. Los aspectos protectores y destructivos identificados se encuentran asociados a mejores o peores resultados en la salud, existe una representación desigual entre civiles y militares.
What has been the most important advancement in neurosurgical practice over the last 10 years?
Authors: Magni Francesco
Published: January 2024

Neurosurgery is considered one of the oldest specialties, with evidence of surgical intervention being observed in skull specimens dating back to pre-history. Yet, the modern idea of neurosurgery is a very recent concept. Increasingly sophisticated technology has revolutionised the field, but arguably the greatest impact on patient outcomes has come from an only seemingly less exciting reform, which has transformed the structure of the service.

 

Over the last decade, efforts have been made to redefine the relationship between patients and healthcare practitioners, in favour of a more holistic and collaborative approach with the patient being placed at the centre of their own care. This shift has particularly impacted specialities like neurosurgery, where meticulous care planning frequently involves input from several other experts and healthcare professionals. Furthermore, advancements in the field of neurosurgery tend to stem from the process of optimisation of techniques, or tool kits, that were actually devised decades ago.

 

True paradigm shifts simply do not occur as frequently, and they are the result of new ways of understanding disease, or new ways of working. The work towards multidisciplinary approaches, patient centred care and social care constitutes the most significant advancement for patient outcomes and satisfaction in the field of neurosurgery over the last decade.
UPAYA MENINGKAT MINAT BELAJAR DAN PRESTASI BELAJAR SISWADENGAN METODE TUTOR SEBAYA DAN LOMBA BERHADIAH
Authors: Miskam MIskam
Published: January 2024

Islamic Religious Education Subjects are the main subjects that must be taught to students from Kindergarten to Higher Education. Judging from the material or scope, Islamic Religious Education broadly consists of 5 scopes, namely; the Qur'an and hadith, Aqedah, Morality, Fiqh and Dates and Islamic culture. Of the five spaces, not all of them are of interest to students. This is especially evident in the lack of feedback from students when the teacher finishes explaining or when the teacher gives students the opportunity to ask questions. In addition, when given questions, both daily test questions, mid-semester tests and semester tests. Of the five materials above, some are less attractive to students and the results are still low, including materials about the Qur'an, especially understanding of reading recitation and interpreting word for word from the verses of the Qur'an being studied. Before this research was conducted, when given questions about reading recitation and interpreting word for word/verse pieces, the average result only reached a maximum of 40%, moreover when it was assessed individually, it only reached 10%. However, after trying it with peer tutoring and prize competition methods, the results were very satisfying. The minimum average score achieved was at least 80%, even a few got a 100% score when viewed individually, and overall, the minimum score achieved was 85%. In addition, children's interest in learning, especially about material related to understanding or studying the verses of the Qur'an, increased more compared to before using this method. Moreover, students were very enthusiastic when an inter-group competition was held and as a reward to the winning group, prizes were given in the form of Scout SKU and scout pocket book.
IMPLEMENTASI PEMBELAJARAN BERBASIS LOTS DAN HOTS PADA KELAS RENDAH DI SDN 49/IV KOTA JAMBI
Authors: Rozalia Dwi Miza
Published: January 2024

This study aims to describe the implementation of LOTS and HOTS-based learning in the lower class at SDN 49/IV Jambi city. This research was conducted at SDN 49/IV Jambi City on 07 January to 07 February 2022. The research approach used was a qualitative approach with the type of case study research. The data in this study are in the form of a description of the implementation of LOTS and HOTS-based learning in low grades obtained through observations and interviews, which indicate that lower grade teachers have prepared LOTS and HOTS-based Learning Implementation Plans (RPP) with grade I, II, and III teachers. as the main data, interviews with lower grade teachers and school principals as well as documentation as supporting data. After collecting data, qualitative data analysis was then carried out. The results showed that the low grade teachers of SDN 49/IV Jambi City had implemented it in designing the LOTS and HOTS-based Learning Implementation Plans (RPP) with good categories. From the research results, the teacher has designed a Learning Implementation Plan (RPP) based on LOTS and HOTS. In LOTS and HOTS-based learning with categories C1, C2, C3 low-level thinking (LOTS) and categories C4, C5, and C6 high-order thinking (HOTS).
IMPLEMENTASI METODE MIND MAPPING PADA PEMBELAJARAN PENDIDIKAN TARIKH DI SMA MUHAMMADIYAH 5 YOGYAKARTA
Authors: Nurudin M Fatwa , Makrufi Anisa Dwi
Published: January 2024

The purpose of this study is to determine the effectiveness of the implementation of the mind mapping method in learning Tarikh Education. This type of research is class action research that is applied to the subject of Date Education for class X students of SMA Muhammadiyah 5 Yogyakarta. Data collection techniques are carried out by observation, interview, and documentation methods. Meanwhile, data analysis is carried out through three stages of activities that occur simultaneously, namely: data reduction, data presentation and drawing conclusions / verification. The results of the study showed that the implementation of the mind mapping method in the learning of Tarikh Education at SMA Muhammadiyah 5 Yogyakarta had a positive impact on students and teachers. Judging from the increase in shiva's understanding and enthusiasm in participating in learning. The conclusion of this study is that the mind mapping method is effective to be implemented in the learning of Tarikh Education at SMA Muhammadiyah 5 Yogyakarta.
Islam Dan Politik Identitas : Studi Tentang Pemahaman Nilai-nilai Pendidikan Islam
Authors: Irwan Syafitri
Published: January 2024

Penelitian ini berjudul “Islam dan Politik Identitas (Studi Tentang Pemahaman Nilai-nilai Pendidikan Islam)”. Fokus utama penelitian ini mengkaji dan menemukan pemikiran FPI sebagai gerakan sosial yang berciri khas politik identitas tentang pendidikan Islam yang berkaitan dengan isu pluralisme, Pancasila, NKRI, Kebhinekaan dan Amar ma’ruf nahi munkar. Secara umum tujuan penelitian ini akan diarahkan untuk mengetahui, pertama, sejarah munculnya gerakan Front Pembela Islam (FPI); kedua, pemikiran Front Pembela Islam (FPI), tentang Pendidikan Islam (pluralisme, Pancasila, NKRI, Kebhinekaan dan ‘amar ma’ruf nahi munkar). Secara khusus, penelitian ini bertujuan untuk mengungkapkan sejumlah fakta yang dapat digunakan untuk menjelaskan dan merumuskan corak, karakteristik, dan dinamika pemikiran Islam serta paradigma baru yang ditawarkannya dan bagaimana korelasinya dalam menjawab tantangan pendidikan Islam di Indonesia. Penelitian ini teorit berupaya menambah khazanah ilmiah dalam tradisi keilmuan Islam dan secara praktis sebagai masukan kepada pihak-pihak terkait.

Penelitian ini menggunakan teori gerakan sosial Quintan Wiktorowicz untuk mengkaji FPI sebagai sebuah gerakan sosial massa berbasis ideologi Islam yang cenderung “radikal”. Sedangkan pendekatan yang digunakan adalah pendekatan sosial historis untuk mengkaji sejarah FPI sebagai gerakan aktivisme dan pendekatan hermeneutik Gadamer untuk menganalisis pesan-pesan atau informasi yang dibawa oleh FPI, khususnya berkaitan dengan pendidikan Islam (Pluralisme, Pancasila, NKRI, Kebhinekaan dan  Amar ma’ruf nahi munkar), Sebagai penelitian lapangan data primer dikumpulkan melalui teknik wawancara (interview) dengan key informan melalui teknik sampling snowball (bola salju) terhadap pengurus FPI dan teknik pemeriksaan keabsahan data menggunakan teknik triangulasi dan content analysis.

Temuan penelitian ini adalah sebagai gerakan sosial Islam, FPI mempunyai kesamaan dengan organisasi Islam lainnya, seperti HTI, FUI, MMI, JAT, dan lainnya. Namun, tak jarang terkadang mereka berbeda tujuan, serta tidak mempunyai pola yang seragam. Berkaitan pemahaman nilai-nilai pendidikan Islam, khususnya Pancasila mereka ingin kembali ke Piagam Jakarta. Demikian pula dengan pluralisme mereka mnolaknya dengan alasan menyamakan semua agama, tetapi mereka menerima pluralisti dalam kaitannya dengan konsep kebhinekaan. Dalam hal, NKRI mereka menghendaki adanya NKRI Bersyari’ah  dan konsep khalifah yang  mirip dengan Paus di Vatican. Tapi konsep khalifah yang mereka inginkan  tidak sama dengan HTI. Tetapi konsep khalifah dalam konsepsi FPI setelah datangnya Imam Mahdi.
KONSEP ILMU MENURUT IBNQAYYIM AL-JAWZIYYAH
Authors: Fatonah Siti
Published: January 2024

One of the challenges of contemporary Islamic thought was the secularization of science. As a result, the values of science in Islam changed, both in terms of the meaning of knowledge, tot hegoalofac achieving knowledge. From these problems, this study aimed to provide a solution by presenting the contribution of one of the previous scholars who was competent in the field of science, namely Imam Ibn Qayyimal-Jauziyah. This research included a character study research using a qualitative method, which described and analyzed Ibn Qayyimal-Jauziyah's thought which was related to the concept of science. The data collection was carried out by means of a literature study. The results of this study revealed the view of Ibn Qayyimal-Jawziyyah that science occupied an important position in the teachings of Islam. It was because of science, that humans could achieve perfect happiness. To achieve this happiness, the author found that Ibn Qayyimal-Jawziyyah mentioned the level of knowledge into three parts from the lowest to the highest level. The higher a person reached the level of knowledge, the more happiness he would get. Thus, this study tried to formulate the concept of knowledge expressed in the works of Ibn Qayyimal-Jawziyyah including Miftāh dar al-Sa'adah, Madārijal-Sālikīn. This effort was expected to provide the spirit of Muslims in studying so that they can achieve true and not false happiness.
An analysis of the existence of the Authority of the Regional Representative Council Against Amendments to the Constitution of the Republic of Indonesia Year 1945 Article 22d Constitutional Law in the Perspective of Islam
Authors: Wardhani Eka Cahya
Published: January 2024

This research is a form of assessment authority of the Regional Representative Council Republic of Indonesia (DPD RI) as a new state agency of Indonesia Constitutional Structure which is the result of the 3rd amendment to the Constitution of 1945. This study aims to (1) know howthe existence of the authority of the Regional Representative Council Republic of Indonesia in the parliamentary system in Indonesia post third amandemenUUD 1945 Article 22D and (2) determine how the authority of the Regional Legislative Assembly of Republic Indonesia d natural analysis of constitutional law I slam. This research is a form of library research that emphasizes a normative juridical approach, namely a review of the legislation which is the focus of this research on the aspects of the existence of the authority of the Regional Representative Council in Article 22D of the Constitution of the Republic of Indonesia . The steps taken in collecting data were collecting books related to the existence of the authority of the Regional Representative Council in article 22 D of the 1945 Constitution and classifying existing data in books or reading material that are related to the problem under study accordingly. with the necessary requirements . Furthermore, the data obtained were analyzed using descriptive analysis techniques.
Education According To The Thought Of Priest Al-Ghazalid And Its Relevance With Education Of Character In Indonesia
Authors: Arliya Lily
Published: January 2024

The focus of this research is "Moral Education According to Imam Al Ghazali's Thought and its Relevance Study with Character Education in Indonesia". This study needs to be carried out to contribute morals and character in the current era of world globalization, especially the formation of morals and character for students, educators and educational staff. Moral education and character education are the keys to true happiness. In order for humans to have good noble morals (akhlakul karimah) and not cause destruction, Allah SWT sent the Prophet Muhammad to improve human morals. This research is a library research. The author examines the values ​​of moral education contained in the book "Ihya Ulumuddin" Imam al-Ghozali, and examining character education in Indonesia, the implementation of the 2013 curriculum, which contains the inculcation of character values ​​which include; Religious character, Honest, Tolerance, Discipline, Hard work, Creative, Independent, Democratic, Curiosity, National spirit or nationalism, Love of the motherland, Respect for achievement, Communicative, Love peace, Love to read, 16) Environmental Care, Social Care, Responsibility answer. The technique of collecting data is by digging up library materials that are relevant to the object of discussion being studied. The approach used is descriptive. While the analysis uses content analysis, which is a method that uses systematic techniques to analyze the contents of the data and review the data. Creative, independent, democratic, curiosity, spirit of nationality or nationalism, love of the homeland, respect for achievement, communicative, love peace, love to read, 16) environmental care, social care, responsibility. The technique of collecting data is by collecting the materials that are relevant to the object of discussion being studied. The approach used is descriptive with content analysis, which is a method that uses systematic techniques to analyze the contents of the data and review the data.
Islam dan Budaya Politik Melayu
Authors: Abdillah Muhammad
Published: January 2024

This paper aims to examine the relationship between Islam and the Malay world which has been widely studied by experts and researchers. A special description of the contestation between Islam and Malay political culture as a form of open-minded society, to be able to see how Islamic and Malay political culture is in a simple way. This research departs from the questions: first, how is Islam in Malay history?; second, how is the dynamics of Islam and Malay political culture. In this paper, qualitative methods are used to clearly examine Islamic and Malay political culture. This paper also aims to show that Islam has an integral role in the history of civilization of the Malay world, besides that Islam also has strong credibility in relation to politics from various perspectives, not only from a religious point of view, but also from a scientific point of view. viewpoint. This research uses a descriptive qualitative approach to look at how to find literature data and interpret the data contained in reference sources and various supporting sources about the contribution of Islamic thought in the Malay world.
Management of Environmental Programs for the Arabic Language at Arrayah Sukabumi University
Authors: Solihati Septia , Mufidah Nuril , Malik Karim Amrullah Abdul
Published: January 2024

The purpose of this research to describe the planning, organization, implementation and supervision of environmental programs at STIBA AR-RAAYAH. This study uses a qualitative research approach with a case study type of research. The results of this study indicate the following: First: setting daily schedules, creating daily work programmes, weekly work programmes, monthly work programmes, and annual work programmes. Second: in the organization are the Student Department, which includes BEM, the Academic Department, and the Curriculum Department. Third: Monitoring and supervising the process of environmental management of the Arabic language at STIBA AR-RAAYAH by looking at the results of the teacher's work and the results of their education, applying learning strategies/methods and the educational achievements of students, and monitoring student behavior. Fourth: The supporting factors in the formation of the Arabic language environment at Al-Raya University: good beginnings, the process of teaching and learning using the Arabic language, not owning anything that is not related to the Arabic language, native speakers, and housing. Fifth: Obstacle factors in creating the Arabic language environment at Al-Raya University: visitors, employees, non-Arabic lessons, and lecturers outside the university.
Resepsi Mu’tazilah pada Dinasti Abbasiyah
Authors: Febriani Fenti
Published: January 2024

This study aims to see how the Muktazilah school played a major role during the Ummayah and Abbasid dynasties by using qualitative methods through a literature research approach, this article aims to look at the political development of the Abbasid Caliphate which was full of ups and downs. It started when the rebels (Mu'tazilah and Shi'a) jointly overthrew the Umayyad caliphate and ended with the fall of Baghdad in the hands of the Mongols. But behind his political struggle, the Mu'tazilah were able to build a strong foundation to spread his teachings, especially to place influential people in the palace. During the caliphate of al-Ma'mun, al-Mu'tashim, and al-Watsiq, the Mu'tazilis gained a strategic position in the Abbasid government, and because of that, controlled state policy. This article tries to reveal how the Mu'tazilites rose in influence in the internal policies of the state to the top, (especially during the mihnah period), and how their glory faded away. This fact led the writer to conclude that Wasil bin 'Atha's (founder of Mu'tazilah) strategy brought the Mu'tazilah to the peak of their political influence. Meanwhile, the controversy surrounding the mihnah itself played a role in the antipathy of the Abbasid people.