bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancement of P2X3 Receptor-Mediated Currents by Lysophosphatidic Acid in Rat Primary Sensory Neurons
Authors: Qiao Wen-Long , Li Qing , Hao Jia-Wei , Wei Shuang , Li Xue-Mei , Liu Ting-Ting , Qiu Chun-Yu , Hu Wang-Ping
Published: June 2022

Lysophosphatidic acid (LPA), a lipid metabolite, plays a role in both neuropathic and inflammatory pain through LPA1 receptors. P2X3 receptor has also been shown to participate in these pathological processes. However, it is still unclear whether there is a link between LPA signaling and P2X3 receptors in pain. Herein, we show that a functional interaction between them in rat dorsal root ganglia (DRG) neurons. Pretreatment of LPA concentration-dependently enhanced α,β-methylene-ATP (α,β-meATP)-induced inward currents mediated by P2X3 receptors. LPA significantly increased the maximal current response of α,β-meATP, showing an upward shift of the concentration-response curve for α,β-meATP. The LPA enhancement was independent on the clamping-voltage. Enhancement of P2X3 receptor-mediated currents by LPA was prevented by the LPA1 receptor antagonist Ki16198, but not by the LPA2 receptor antagonist H2L5185303. The LPA-induced potentiation was also attenuated by intracellular dialysis of either G-protein inhibitor or protein kinase C (PKC) inhibitor, but not by Rho inhibitor. Moreover, LPA significantly changed the membrane potential depolarization and action potential burst induced by α,β-meATP in DRG neurons. Finally, LPA exacerbated α,β-meATP- induced nociceptive behaviors in rats. These results suggested that LPA potentiated the functional activity of P2X3 receptors in rat primary sensory neurons through activation of the LPA1 receptor and its downstream PKC rather than Rho signaling pathway, indicating a novel peripheral mechanism underlying the sensitization of pain.
Understanding the Prooxidant Action of Plant Polyphenols in the Cellular Microenvironment of Malignant Cells: Role of Copper and Therapeutic Implications
Authors: Farhan Mohd , Rizvi Asim
Published: June 2022

Plant derived polyphenolic compounds are considered critical components of human nutrition and have shown chemotherapeutic effects against a number of malignancies. Several studies have confirmed the ability of polyphenols to induce apoptosis and regression of tumours in animal models. However, the mechanism through which polyphenols modulate their malignant cell selective anticancer effects has not been clearly established. While it is believed that the antioxidant properties of these molecules may contribute to lowering the risk of cancer induction by causing oxidative damage to DNA, it could not be held responsible for chemotherapeutic properties and apoptosis induction. It is a well known fact that cellular copper increases within the malignant cell and in serum of patients harboring malignancies. This phenomenon is independent of the cellular origin of malignancies. Based on our own observations and those of others; over the last 30 years our laboratory has shown that cellular copper reacts with plant derived polyphenolic compounds, by a Fenton like reaction, which generates reactive oxygen species and leads to genomic DNA damage. This damage then causes an apoptosis like cell death of malignant cells, while sparing normal cells. This communication reviews our work in this area and lays the basis for understanding how plant derived polyphenols can behave as prooxidants (and not antioxidants) within the microenvironment of a malignancy (elevated copper levels) and gives rationale for their preferential cytotoxicity towards malignant cells.
OSAFT Library: An Open-Source Python Library for Acoustofluidics
Authors: Fankhauser Jonas , Goering Christoph , Dual Jürg
Published: June 2022

In this article, we present the Open-Source AcoustoFluidics Theories (OSAFT) library (version 0.9.14), a Python library for acoustofluidics. The focus of the library is the classical problem of a particle suspended in a fluid and subjected to an incident acoustic wave. The Python code provides easy access to a number of theories describing acoustic scattering, acoustic streaming, and most importantly the acoustic radiation force exerted on the particle. At the time of submission of this article, six different theoretical models and various limiting cases thereof are available. All are treating the problem of a single, spherical particle in an infinite 3D-domain subjected to an incident plane standing or plane traveling wave. The implementations of further theories are currently under development. Our code is designed to be extensible. A library of fluid and solid material models facilitates the implementation of new theories. A unified application programming interface (API), which is used across all models, makes comparisons between different theories straightforward. Such comparisons can be made directly by the user or through the plotting capabilities of our library. The code is distributed through Python’s standard software repository PyPi. Illustrative examples on the project’s website serve as a starting point for learning the library’s API. For a more in-depth understanding of the code, complete documentation of the codebase, directed at users as well as future collaborators, is available online. In an effort to make the library as extensive as possible, the authors of this article are looking for collaborators on the project.
A New Modified Analytical Approach for the Solution of Time-Fractional Convection–Diffusion Equations With Variable Coefficients
Authors: Khan Hassan , Kumam Poom , Hajira  , Khan Qasim , Tchier Fairouz , Sitthithakerngkiet Kanokwan , Dassios Ioannis
Published: June 2022

In this article, a new modification of the Adomian decomposition method is performed for the solution fractional order convection–diffusion equation with variable coefficient and initial–boundary conditions. The solutions of the suggested problems are calculated for both fractional and integer orders of the problems. The series of solutions of the problems with variable coefficients have been provided for the first time. To verify and illustrate our new technique, four numerical examples are presented and solved by using the proposed technique. The derived results are plotted, and the dynamics are shown for both fractional and integer orders of the problems. An excellent variation among the solutions at various fractional orders is observed. It is analyzed that the new technique based on the Adomian decomposition method is accurate and effective. The present method fits both the initial and boundary conditions with double approximations simultaneously, which increases the accuracy of the present method. For the first time, the present technique is used for the solutions of the problems with variable coefficients along with initial and boundary conditions. It is therefore suggested to apply the present procedure for the solutions of other problems with variable order and coefficients along with initial and boundary conditions.
Classifying Beers With Memristor Neural Network Algorithm in a Portable Electronic Nose System
Authors: Zafar Imran , Cui Yuanhui , Bai Qinghao , Yang Yanqing
Published: June 2022

Quality control and counterfeit product detection have become exceedingly important due to the vertical market of beers in the global economy. China is the largest producer of beer globally and has a massive problem with counterfeit alcoholic beverages. In this research, a modular electronic nose system with 4 MOS gas sensors was designed for collecting the models from four different brands of Chinese beers. A sample delivery subsystem was fabricated to inject and clean the samples. A software-based data acquisition subsystem was programmed to record the time-dependent chemical responses in 28 different models. A back-propagation neural network based on a memristor was proposed to classify the quality of the beers. Data collected from the electronic nose system were then used to train, validate, and test the created memristor back-propagation neural network model. Over 70 tests with changes in the setup parameters, feature extraction methods, and neural network parameters were performed to analyze the classification performance of the electronic nose hardware and neural network. Samples collected from 28 experiments showed a deviation of 9% from the mean value. The memristor back-propagation network was able to classify four brands of Chinese beers, with 88.3% of classification accuracy. Because the memristor neural network algorithm is easy to fabricate in hardware, it is reasonable to design an instrument with low cost and high accuracy in the near future.
MicroRNA-34a: A Novel Therapeutic Target in Fibrosis
Authors: Zhao Min , Qi Qin , Liu Shimin , Huang Rong , Shen Jiacheng , Zhu Yi , Chai Jing , Zheng Handan , Wu Huangan , Liu Huirong
Published: June 2022

Fibrosis can occur in many organs, and severe cases leading to organ failure and death. No specific treatment for fibrosis so far. In recent years, microRNA-34a (miR-34a) has been found to play a role in fibrotic diseases. MiR-34a is involved in the apoptosis, autophagy and cellular senescence, also regulates TGF-β1/Smad signal pathway, and negatively regulates the expression of multiple target genes to affect the deposition of extracellular matrix and regulate the process of fibrosis. Some studies have explored the efficacy of miR-34a-targeted therapies for fibrotic diseases. Therefore, miR-34a has specific potential for the treatment of fibrosis. This article reviews the important roles of miR-34a in fibrosis and provides the possibility for miR-34a as a novel therapeutic target in fibrosis.
Sequence Characteristics and Phylogenetic Analysis of the Artemisia argyi Chloroplast Genome
Authors: Chen Changjie , Miao Yuhuan , Luo Dandan , Li Jinxin , Wang Zixin , Luo Ming , Zhao Tingting , Liu Dahui
Published: June 2022

Artemisia argyi Levl. et Van is an important Asteraceae species with a high medicinal value. There are abundant A. argyi germplasm resources in Asia, especially in China, but the evolutionary relationships of these varieties and the systematic localization of A. argyi in the family Asteraceae are still unclear. In this study, the chloroplast (cp) genomes of 72 A. argyi varieties were systematically analyzed. The 72 varieties originated from 47 regions in China at different longitudes, latitudes and altitudes, and included both wild and cultivated varieties. The A. argyi cp genome was found to be ∼151 kb in size and to contain 114 genes, including 82 protein-coding, 28 tRNA, and 4 rRNA genes. The number of short sequence repeats (SSRs) in A. argyi cp genomes ranged from 35 to 42, and most of them were mononucleotide A/T repeats. A total of 196 polymorphic sites were detected in the cp genomes of the 72 varieties. Phylogenetic analysis demonstrated that the genetic relationship between A. argyi varieties had a weak relationship with their geographical distribution. Furthermore, inverted repeat (IR) boundaries of 10 Artemisia species were found to be significantly different. A sequence divergence analysis of Asteraceae cp genomes showed that the variable regions were mostly located in single-copy (SC) regions and that the coding regions were more conserved than the non-coding regions. A phylogenetic tree was constructed using 43 protein-coding genes common to 67 Asteraceae species. The resulting tree was consistent with the traditional classification system; Artemisia species were clustered into one group, and A. argyi was shown to be closely related to Artemisia lactiflora and Artemisia montana. In summary, this study systematically analyzed the cp genome characteristics of A. argyi and compared cp genomes of Asteraceae species. The results provide valuable information for the definitive identification of A. argyi varieties and for the understanding of the evolutionary relationships between Asteraceae species.
Elucidating Plant-Microbe-Environment Interactions Through Omics-Enabled Metabolic Modelling Using Synthetic Communities
Authors: Beck Ashley E. , Kleiner Manuel , Garrell Anna-Katharina
Published: June 2022

With a growing world population and increasing frequency of climate disturbance events, we are in dire need of methods to improve plant productivity, resilience, and resistance to both abiotic and biotic stressors, both for agriculture and conservation efforts. Microorganisms play an essential role in supporting plant growth, environmental response, and susceptibility to disease. However, understanding the specific mechanisms by which microbes interact with each other and with plants to influence plant phenotypes is a major challenge due to the complexity of natural communities, simultaneous competition and cooperation effects, signalling interactions, and environmental impacts. Synthetic communities are a major asset in reducing the complexity of these systems by simplifying to dominant components and isolating specific variables for controlled experiments, yet there still remains a large gap in our understanding of plant microbiome interactions. This perspectives article presents a brief review discussing ways in which metabolic modelling can be used in combination with synthetic communities to continue progress toward understanding the complexity of plant-microbe-environment interactions. We highlight the utility of metabolic models as applied to a community setting, identify different applications for both flux balance and elementary flux mode simulation approaches, emphasize the importance of ecological theory in guiding data interpretation, and provide ideas for how the integration of metabolic modelling techniques with big data may bridge the gap between simplified synthetic communities and the complexity of natural plant-microbe systems.
The Impact of Pro-environmental Awareness Components on Green Consumption Behavior: The Moderation Effect of Consumer Perceived Cost, Policy Incentives, and Face Culture
Authors: Shen Minmin , Wang Jianhua
Published: June 2022

Based on the survey data of 839 consumers in Jiangsu and Anhui provinces, this article explores the formation mechanism and internal driving force of Chinese consumers’ green consumption, and clarifies the effect of consumers’ pro-environmental awareness components on green consumption and the moderating effect of perceived cost, policy incentives, and face culture. The results of the study show that pro-environmental awareness is the basis for green consumption. However, groups with pro-environmental awareness do not choose green consumption for sure. The transformation from awareness to behavior is also affected by many factors. Consumers’ perceived cost is an important obstacle to green consumption, while the face culture in Chinese society has a certain role in promoting green consumption. In this study, government policy incentives have no significant direct impact and moderating effect on consumers’ green consumption.
Is There a Link Between Green Human Resource Management and Consumer Buying Behavior? The Moderating Role of Employee Diffidence
Authors: Xiao Yunxia , Younus Rabia , Saeed Wizra , Ul Haq Junaid , Li Xiuwen
Published: June 2022

Green Human Resource Management (HRM) supports promoting and incorporating sustainable development with regard to their resources. Managers and customers actively utilize the limited resources efficiently and effectively to accomplish environment-friendly goals and objectives. The study focuses on investigating the moderating role of diffidence between Green HRM, among eco-friendly behavior and Employee Performance of frontline employees of the hospitality sector. Two hundred ten individuals particapted in the research from hospitality sector with regard to examine green HRM policies of employees along with their influence on consumer buying behvaiour. Frontline employees incorporated the data on HRM performance, eco-friendly behavior, and diffidence. Besides, consumers gave their opinion on consumer buying behavior. The study’s findings revealed that Green HRM, aka Green HRM, directly impacts consumer behavior. In addition to this diffidence moderates the relationship between Green HRM and employee performance and employee eco-friendly behavior. Besides, future studies can explore the clothing and banking sector as the current study was conducted in fast food sector.
Zhongyong Thinking Style and Resilience Capacity in Chinese Undergraduates: The Chain Mediating Role of Cognitive Reappraisal and Positive Affect
Authors: Zhou Shisi , Li Xueping
Published: June 2022

Previous studies have suggested that the Zhongyong thinking style (influenced by Chinese culture) is associated with psychological features. However, little is known about the direct association between Zhongyong thinking and resilience and the underlying mechanisms of this relationship in Chinese culture. The present study aimed to investigate the association between Zhongyong thinking and undergraduates’ resilience and to assess whether cognitive reappraisal and positive effects mediated this association. A sample of undergraduates (n= 1,356, 70.4% female, mean age = 19 years) was recruited for this study and the participants completed the Zhongyong Thinking Style Scale (ZYTS), the Emotion Regulation Questionnaire (ERQ), the Positive Affect and Negative Affect Scale (PANAS), and the Resilience-11. Results indicated that the Zhongyong thinking style was positively and significantly associated with resilience. Undergraduates’ resilience was affected by Zhongyong thinking partly through 3 different pathways: the mediating role of cognitive reappraisal, the mediating role of positive effect, and the mediating chain role of both cognitive reappraisal and positive effect. These findings might provide a deeper understanding of the protective factors for resilience among Chinese undergraduates.
Evidence-Based Analysis of Social Impact Bonds for Homelessness: A Scoping Review
Authors: Wang Huan , Xu Xiaoguang
Published: June 2022

Social impact bonds (SIBs) have emerged as an innovative financial instrument designed to support the social service sector in delivering innovative social programs. In particular, SIBs can be used to finance prevention of homelessness among those regarded as vulnerable. There is little evidence that outcomes from SIB-funded programs are significantly different compared to more traditional programs. This is the first scoping review of academic and gray literature that explores the main features and outcomes from all SIBs for homelessness based on evidence, addressing an important gap in the literature. The scoping review provides a transparent and comprehensive approach for mapping areas of this research. A total of 73 studies and articles were found eligible for inclusion. These concerned 32 SIBs for homelessness implemented in the United Kingdom, the United States, Australia, and Belgium. The review found that academic papers on SIBs for homelessness lack evidence-based analysis, while gray literature lacks transparency, especially in evaluation method and outcome. We found that fourteen projects met their target outcomes. The common features of these SIBs were a navigator intervention model, effective partnership working, and use of Special Purpose Vehicles. Our findings show that it is necessary for the managers of SIBs to improve outcome metrics and evaluation methods, support target groups fairly, and attract more private investors to finance SIBs for better addressing homelessness.
The Impact of Negative Workplace Gossip on Employees’ Organizational Self-Esteem in a Differential Atmosphere
Authors: Song Xiaolei , Guo Siliang
Published: June 2022

The level of organizational self-esteem of employees, whether on the production line or as managers or directors of enterprises, does not only correlate with individual performance but has also become a key factor in determining the completion of team core tasks. Based on the theory of self-consistency, this study explores the correlation between negative workplace gossip and employees’ organizational self-esteem by revealing the intermediary role of workplace exclusion and poor-order atmosphere. A survey of 228 employees from enterprises in Shandong and Shanghai showed that negative workplace gossip exerted a significant negative impact on employees’ organizational self-esteem, suggesting that negative workplace gossip reduces employees’ organizational self-esteem in the context of Chinese organizations. In addition, workplace exclusion exerted a complete intermediary effect between negative workplace gossip and employees’ organizational self-esteem, and poor-order atmosphere perception played a partial intermediary role. This study uncovers the black box that negative workplace gossip affects employees’ organizational self-esteem and has a strong enlightening significance for management practice.
Tactile Low Frequency Vibration in Dementia Management: A Scoping Review
Authors: Campbell Elsa A. , Kantor Jiří , Kantorová Lucia , Svobodová Zuzana , Wosch Thomas
Published: June 2022

The prevalence of dementia is increasing with the ever-growing population of older adults. Non-pharmacological, music-based interventions, including sensory stimulation, were reported by the Lancet Commission in 2020 to be the first-choice approach for managing the behavioural and psychological symptoms of dementia. Low frequency sinusoidal vibration interventions, related to music interventions through their core characteristics, may offer relief for these symptoms. Despite increasing attention on the effectiveness of auditory music interventions and music therapy for managing dementia, this has not included low frequency vibration. This scoping review, following the JBI methodology guidelines, was conducted to investigate participants’ responses to both sound and mechanical vibration, the characteristics of the delivered interventions, methodological challenges, and the specifics of the research experiments reported. An extensive search was conducted in BMC, CINAHL, Cochrane Central Register of Controlled Trials, EMBASE, ERIC, MEDLINE (OvidSP), Pedro, ProQuest Central, PsycINFO, Scopus, and Web of Science. Current Controlled Trials, Clinical Trials, and Google Scholar were also searched as well as a hand search in relevant journals. Studies on adults with all types of dementia, investigating tactile low frequency sound or mechanical vibration in any context were considered. Data from eight full-length studies (three RCTs, two quasi-experimental, two case reports, and one qualitative) were extracted using the data extraction table developed by the authors and were included in the analysis and critical appraisal. Issues in quality related to, for example, control groups and blinding. Few studies addressed participants’ subjective responses to the interventions. Reporting on the intervention characteristics was unclear. It appeared more frequent sessions led to better outcomes and home-based interventions potentially addressing the issue of access and feasibility. Future research should include neuroimaging to measure and confirm the hypothesised mechanism of cerebral coherence. Standardised reporting of intervention characteristics is also needed to ensure replicability of the experiments. Higher quality research is needed to investigate the impact and effect of low frequency vibration for the symptoms of dementia and compare outcomes in meta-syntheses.
A Randomized Controlled Trial Study of a Multimodal Intervention vs. Cognitive Training to Foster Cognitive and Affective Health in Older Adults
Authors: Brasser Maria , Frühholz Sascha , Schneeberger Andres R. , Ruschetti Gian G. , Schaerli Rahel , Häner Michèle , Studer-Luethi Barbara
Published: June 2022

Research over the past few decades has shown the positive influence that cognitive, social, and physical activities have on older adults’ cognitive and affective health. Especially interventions in health-related behaviors, such as cognitive activation, physical activity, social activity, nutrition, mindfulness, and creativity, have shown to be particularly beneficial. Whereas most intervention studies apply unimodal interventions, such as cognitive training (CT), this study investigates the potential to foster cognitive and affective health factors of older adults by means of an autonomy-supportive multimodal intervention (MMI). The intervention integrates everyday life recommendations for six evidence-based areas combined with psychoeducational information. This randomized controlled trial study compares the effects of a MMI and CT on those of a waiting control group (WCG) on cognitive and affective factors, everyday life memory performance, and activity in everyday life. Three groups, including a total of 119 adults aged 65–86 years, attended a 5- or 10-week intervention. Specifically, one group completed a 10-week MMI, the second group completed 5-week of computer-based CT followed by a 5-week MMI, whereas the third group paused before completing the MMI for the last 5 weeks. All participants completed online surveys and cognitive tests at three test points. The findings showed an increase in the number and variability of activities in the everyday lives of all participants. Post hoc analysis on cognitive performance of MMI to CT indicate similar (classic memory and attention) or better (working memory) effects. Furthermore, results on far transfer variables showed interesting trends in favor of the MMI, such as increased well-being and attitude toward the aging brain. Also, the MMI group showed the biggest perceived improvements out of all groups for all self-reported personal variables (memory in everyday life and stress). The results implicate a positive trend toward MMI on cognitive and affective factors of older adults. These tendencies show the potential of a multimodal approach compared to training a specific cognitive function. Moreover, the findings suggest that information about MMI motivates participants to increase activity variability and frequency in everyday life. Finally, the results could also have implications for the primary prevention of neurocognitive deficits and degenerative diseases.
Risk Prediction and Assessment of Intervention, Re-education and Reintegration of Juvenile Offenders: Development and Psychometric Properties of the PREVI-A
Authors: Graña Gómez José Luis , Ronzón-Tirado Román , Andreu Rodríguez José Manuel , de la Peña Fernández María Elena
Published: June 2022

This paper proposes and analyzes the psychometric properties of the PREVI-A scale (Predicción del Riesgo y Valoración de la Intervención en la ARRMI—-Risk Prediction and Intervention Assessment in the ARRMI). It describes the process of item development, the factorial structure of the scale, reliability, evidence of validity and diagnostic performance with regard to recidivism risk in juvenile offenders. The sample was made up of 212 juvenile offenders held at detention centers run by the Madrid Agency for Reeducation and Reintegration of Juvenile Offenders, a regional government body. Statistical analyses were used to corroborate the theoretical factorial structure of the PREVI-A, which consists of six risk/protection dimensions (64 items) based on the Risk-Needs-Responsivity Model, and to obtain empirical support for the reliability and validity of PREVI-A as a tool to assess the risk of recidivism by juvenile offenders in Spain.
The English as a Foreign Language Learners’ Psychological and Emotional Perceptions on Technology Integration in Language Classrooms
Authors: Yu Xiao
Published: June 2022

Recently, the use of new educational technologies in language teaching development is expanding rapidly. Educational technologies attach new features to the learning environments. The integration of educational technologies in language teaching has been received special attention among language researchers. In so doing, the present study investigated language learners’ perceptions of the integration of innovative educational technologies in their language classrooms. The sample comprised 301 English as a foreign language (EFL) students with different academic qualifications from Shaanxi Province (299) and other provinces (Fujian province = 1, Sichuan province = 1) in China. To gather the necessary data, the researcher conducted a technology integration questionnaire and a focus group interview. The results of obtained data demonstrated that the language learners had positive attitudes toward using technology in their classrooms. However, the findings of the interviews indicated that learners had some problems such as lack of technology literacy and inadequate assess to facilities in participating in technology-based classroom activities.
About-Weekly Pattern in the Dynamic Complexity of a Healthy Subject’s Cellular Immune Activity: A Biopsychosocial Analysis
Authors: Seizer Lennart , Cornélissen-Guillaume Germaine , Schiepek Günter K. , Chamson Emil , Bliem Harald R. , Schubert Christian
Published: June 2022

In a previous integrative single-case study, we collected biological, psychological and social time-series data on a 25-year-old healthy woman over the course of 126 12-h intervals (63 days) and used urinary neopterin as an indicator of cellular immune activity [Schubert et al. 2012 (1)]. The present re-evaluation introduced Dynamic Complexity (DC) as an additional non-linear and non-stationary measure to further investigate the subject’s biopsychosocial dynamics during the study. The new time series dealing with urinary neopterin complexity revealed a cyclic, circaseptan (about-weekly) repeating pattern (6.59 days). The only weekly reoccurring events over the course of the study that were associated with this immunological pattern were the in-depth interviews with the subject (mean distance between interviews: 6.5 days). Superposed epoch analysis (SEA) revealed a U-shaped relation between neopterin complexity and interviews, with a decrease in neopterin complexity before and during interviews and an increase after interviews. Furthermore, the complexity scores for irritation, anxiousness/depressiveness and mental activity were positively correlated with neopterin complexity. The results suggest that the interviews, which had been found to be related to the subject’s need for educational and/or social accomplishment, were marked by stress (decrease in psycho-immunological flexibility and adaptability), which was then relieved after the interviews (increase in psycho-immunological flexibility and adaptability). It appears that the subject’s cellular immune activity, as indicated by neopterin complexity, functionally mirrored the emotional meaning she ascribed to the in-depth interviews. This re-evaluation is in line with the view that biopsychosocial research requires multimodal analysis of single cases based on qualitative (e.g., in-depth interviews) and quantitative (e.g., time series analysis) data under conditions of “life as it is lived”.
Social Support and Coping Style of Medical Residents in China: The Mediating Role of Psychological Resilience
Authors: Xu Chao , Wang Yongyi , Wang Zongqin , Li Biao , Yan Chuandong , Zhang Sheng , Chen Bei , Zhang Di , Peng Juan
Published: June 2022

Objectives

Recent surveys have paid insufficient attention to the psychological status of medical residents, but medical residents, as a special group of medical workers, need to be focused on. This study aimed to investigate medical residents' levels of social support, psychological resilience, and coping style, and explore the mediating role of psychological resilience, which can ultimately provide a new theoretical basis for improving medical residents' psychological status and quality of work and life.

Methods

A total of 577 medical residents from China were investigated by an online questionnaire, using convenience sampling. Associations between social support, psychological resilience, and coping styles were assessed using Pearson correlation analysis. The mediating effect of psychological resilience was tested using SPSS Process.

Results

Positive correlations between social support, psychological resilience and coping style were found (r = 0.474, P < 0.001; r = 0.473, P < 0.001; r = 0.353, P < 0.001). The mediating effect of psychological resilience in the relationship between social support and coping style was significant (95% CI: 0.168, 0.384), and accounted for 25.84%.

Conclusion

Attention should be paid to the psychological status of medical residents, and social support and psychological flexibility can be used to increase the enthusiasm for their coping style and promote their mental health.
Perceived Family Function and Associated Predictors in Nurses: A Cross-Sectional Study
Authors: Zeng Wen , Fang Qian , Wang Cui , Tong Beibei , Li Dan , Zou Ziqiu , Liu Peiyuan , Yao Yuanrong , Shang Shaomei
Published: June 2022

Background

Nurses play a key role in the health care system. However, clinical nurses experience different kinds of stressors that might impact the nurses' quality of life or quality of care. Family is one of the main social support resources, and quality family function might improve the quality of care provided by nurses. However, evidence on family function in Chinese clinical nurses is quite limited.

Objectives

The current study was to evaluate the family function of the Chinese clinical nurses, and to explore associated predicting factors.

Methods

A multi-center cross-sectional anonymous online survey was carried out. Chinese Family Function Scale was used in the study. Spearman's rank correlation analysis, Mann-Whitney U test, or Kruskal-Wallis H test was performed in the univariate analysis. The pairwise comparison method was used to determine whether the difference was significant between pair groups. Categorical regression (optimal scaling regression) was the main method to analyze factors that had been confirmed to be statistically significant in the univariate analysis.

Results

Nineteen thousand four hundred and twenty-two nurses completed the online questionnaires. The median of the nurse's perceived family function score was three (Inter-quartile Range: IQR 2–5). The multivariate analysis showed that the highest education level (P <0.001), the hospital level (P <0 .001), rotation shift status (P <0.001), working department (P < 0.001), number of children (P < 0.001), monthly income per family member (P < 0.001) were significantly associated with family function. Moreover, the importance of the factors was the number of children (49.1%), monthly income per family member (20.7%), rotation shift status (12.4%), the highest education level (8.0%), the hospital level (7.6%), and working department (2.4%) in turn.

Conclusions

The family function was associated with multiple factors, which hints that managers, leaders, and government could make strategies to improve nurses' family function in order to lead nurses to make a balance between family and work. Policymakers, nursing managers, and employers should make strategies such as promoting children-care services, increasing nurses' income, educating and training enough nurses, and building a well-established system of career development to help clinical nurses improve their family function so that to improve the quality of care.
Chronic Noise Exposure and Risk of Dementia: A Systematic Review and Dose-Response Meta-Analysis
Authors: Meng Linghao , Zhang Yang , Zhang Shushan , Jiang Fugui , Sha Leihao , Lan Yajia , Huang Lei
Published: June 2022

Objective

Evidence is scarce about the effect of noise exposure on the risk of dementia. We conducted a systematic review and dose-response meta-analysis, aiming to explore the association between noise exposure and the risk of dementia.

Methods

We searched PubMed, EMBASE and the Cochrane Library to collect studies on chronic noise exposure and the risk of dementia from database inception to September 18, 2021 without language limitations. Two authors independently screened the literature, extracted data and assessed the risk of bias of the included studies. A dose-response meta-analysis and subgroup analysis were then conducted to detect the association between noise exposure and the risk of dementia by using Stata 14.0 software. This study is registered on PROSPERO (CRD42021249243).

Results

A total of 11 studies were eligible for qualitative synthesis, and nine were eligible for quantitative data synthesis. All of them showed moderate to high quality scores in the assessment of risk of bias. We found a positive linear association between the noise increment and dementia risk (R2 = 0.58). When noise exposure increased 57 dB, the RR of dementia was 1.47 (95% CI: 1.21–1.78). From the outcome subgroup of AD, AD and dementia, VaD and NAD, we also found a positive association (R2 = 0.68, 0.68, 0.58, respectively). When noise exposure increased by 25 dB, the RRs were 1.18 (95% CI: 1.14–1.23), 1.19 (95% CI: 1.14–1.23) and 1.17 (95% CI: 1.06–1.30), respectively. We found a nonlinear association between the noise increment and dementia risk when only cohort studies were included (R2 = 0.58). When noise exposure increased by 25 dB, the RR of dementia was 1.16 (95% CI: 1.12–1.20). From the subgroup of AD, AD and dementia, VaD and NAD of cohort studies, the regression curve showed a nonlinear positive association (R2 = 0.74, 0.71, 0.43, respectively). When noise exposure increased by 25 dB, the RRs were 1.17 (95% CI: 1.12–1.21), 1.17 (95% CI: 1.12–1.22) and 1.13 (95% CI: 0.99–1.28), respectively.

Conclusion

Based on the current evidence, exposure to noise may be a specific risk factor for dementia. To better prevent dementia, more rigorously designed studies are needed to explore the etiological mechanism of noise and dementia.
A Community-Informed Approach to COVID-19 Vaccine Roll-Out in Under-served Areas in Chicago
Authors: DiVirgilio Laura , Boshara Arianna , Hunt Bijou R. , Jacobs Jacquelyn , Just Kate , Johnson Amy K.
Published: June 2022

The availability of the COVID-19 vaccine in the US created an urgent need for strategies to achieve widespread vaccine distribution, but approaches to achieving equitable distribution, including reaching communities of color, varied across the country. To add to the knowledge base around targeted vaccine roll-out among underserved communities, the current study presents results from patient vaccination data and staff interviews conducted at Sinai Chicago, a safety-net healthcare system serving under-resourced communities. A total of 11,313 patients received at least one dose of Pfizer or Moderna COVID-19 vaccine between January and October 2021 at a Sinai Chicago facility. The sample was primarily comprised of Hispanic and non-Hispanic Black persons, with a mean age of 47 years, and was split evenly between female and male individuals. Compared to non-Hispanic White persons, Hispanic persons were 1.4 times more likely to have completed the full course of vaccination, while non-Hispanic Black persons were 40% less likely. People ages 18–24 were less likely to be fully vaccinated compared to all other adult age groups. Compared to privately insured persons, publicly insured persons were 40% less likely to have been fully vaccinated. The vaccine roll-out approach focused on educating the community through town halls and targeted messaging to address common myths and misconceptions about the vaccine, as well as developing the necessary infrastructure to administer the vaccine in a variety of community settings. This study illustrates COVID-19 vaccine roll-out in an under-resourced urban area in Chicago and provides insight on future implementation of vaccine intervention in hard to reach communities.
The Network of Services for COVID-19 Vaccination in Persons With Mental Disorders: The Italian Social Health System, Its Organization, and Bioethical Issues
Authors: Scendoni Roberto , Fedeli Piergiorgio , Cingolani Mariano
Published: June 2022

The adoption of restrictive measures aimed at curtailing the spread of SARS-CoV2 has had a harmful impact on socio-affective relationships, while limiting the scope of interventions and activities to promote social inclusion, with considerable negative repercussions for patients with mental disorders. Vaccination has been and will continue to be a valid tool to overcome the barriers of social isolation and to protect the health of this category of patients. In this paper we present an overview of the Italian network of social and healthcare services for COVID-19 vaccination among patients with mental disorders. Some aspects of medical ethics are discussed in order to share good practices for improving the health of this vulnerable group of people. We then consider the measures implemented by the health system in Italy to deal with the phenomenon of vaccine hesitancy before addressing the issue of autonomy and restricted access to vaccination points. Finally, we illustrate some of the perspectives already adopted by the Italian system, which may be useful to the global scientific community.
Knowledge Structure and Emerging Trends of Telerehabilitation in Recent 20 Years: A Bibliometric Analysis via CiteSpace
Authors: Zheng Jiaqi , Hou Meijin , Liu Lu , Wang Xiangbin
Published: June 2022

Purpose

Telerehabilitation, as an effective means of treatment, is not inferior to traditional rehabilitation, and solves the problem of many patients who do not have access to hospital-based training due to costs and distance. So far, the knowledge structure of the global use of telerehabilitation has not been formed. This study aimed to demonstrate the state of emerging trends and frontiers concerning the studies of telerehabilitation through bibliometric software.

Methods

Literature about telerehabilitation from 2000 to 2021 was retrieved from the Web of Science Core Collection. We used CiteSpace 5.8.R3 to analyze the publication years, journals/cited journals, countries, institutions, authors/cited authors, references, and keywords. Based on the analysis results, we plotted the co-citation map to more intuitively observe the research hotspots and knowledge structure.

Results

A total of 1,986 records were obtained. The number of annual publications gradually increased over the investigated period. The largest increase occurred between 2019 and 2020. J TELEMED TELECARE was the most prolific and the most cited journal. The United States was the most influential country, with the highest number of publications and centrality. The University of Queensland was the most productive institution. The author Tousignant M ranked the highest in the number of publications and Russell TG ranked the first in the cited authors. Respectively, the articles published by Cottrell MA and Russell TG ranked the first in the frequency and centrality of cited references. The four hot topics in telerehabilitation were “care”,“stroke”, “telemedicine” and “exercise”. The keyword “stroke” showed the strongest citation burst. The two frontier keywords were “physical therapy” and “participation”. The keywords were clustered to form 21 labels.

Conclusion

This study uses visualization software CiteSpace to provide the current status and trends in clinical research of telerehabilitation over the past 20 years, which may help researchers identify new perspectives concerning potential collaborators and cooperative institutions, hot topics, and research frontiers in the research field. Bibliometric analysis of telerehabilitation supplements and improves the knowledge field of telemedicine from the concept of rehabilitation medicine and provides new insights into therapists during the COVID-19 pandemic.
Social Support and Depressive Symptoms Among Adolescents During the COVID-19 Pandemic: The Mediating Roles of Loneliness and Meaning in Life
Authors: Liu Ying , Hu Jinsheng , Liu Jia
Published: June 2022

Identifying which factors influence depressive symptom during the COVID-19 pandemic is highly significant for psychological crisis interventions among adolescents. Social support is likely to be one of the main factors. However, the underlying mechanism is still not well understood in the context of COVID-19. The current study examines whether loneliness and meaning in life mediate the association between social support and depressive symptoms in adolescents. A sample of 1,317 high school students in China were surveyed using the Perceived Social Support Scale, the Chinese Child Loneliness Scale, the Meaning in Life Questionnaire, and the Beck Depression Inventory-II. The results showed that social support predicted depressive symptoms directly and indirectly by enhancing loneliness and diminishing the sense of meaning in life. These findings help in providing new entry points in the design of effective depression prevention and intervention for adolescents during the COVID-19 pandemic.
Oscillatory Structural Forces Across Dispersions of Micelles With Variable Surface Charge
Authors: Ludwig Michael , Ritzert Philipp , Geisler Ramsia , Prévost Sylvain , von Klitzing Regine
Published: June 2022

GRAPHICAL ABSTRACT
A Critical Review of Maturity Model Development in the Digitisation Era
Authors: Adekunle Samuel Adeniyi , Aigbavboa Clinton , Ejohwomu Obuks , Ikuabe Matthew , Ogunbayo Babatunde
Published: June 2022

Maturity models assess the prevailing capability level and proffer the necessary capabilities for effective adoption in a systematic roadmap. This is considered essential to achieve diffusion of the emerging technologies. The paper provides a guide to maturity model development in the digitisation era. This study adopted scientometrics and meta-synthesis to critically review and provide guidance on maturity model development. Firstly, bibliographic data was collected from the Scopus database and analysed using Scientometrics. Secondly, developed BIM maturity models were critically reviewed. The study identified areas of maturity model deployment and the industries of deployment. It also identified the present areas of deployment of maturity models. The second aspect critically reviewed selected BIM maturity models through stated parameters and outlined the necessary criteria for maturity model development. Maturity model is widely adopted to achieve optimisation and proper assessment in various industries. The study identified the industries where it is deployed and identified the areas of maturity model deployment in the digitisation era. In addition, it was observed that some existing BIM maturity models do not conform to the various requirements expected of a maturity model. The study is unique in the methods adopted to achieve its results. Also, it identified the areas of maturity model deployment. The study is helpful as it provides the criteria for maturity model development hereafter, while also helping BIM users choose among the existing BIM maturity models. The study is crucial for proper maturity model development in the digitisation era.
Table-Grape Cultivation in Soil-Less Systems: A Review
Authors: Pisciotta Antonino , Barone Ettore , Di Lorenzo Rosario
Published: June 2022

Table grape (Vitis vinifera L.) is considered to be one of the most popular fruit crops in the world. Italy is the leading table-grape producer in the EU and is the main European exporting country. However, to stay competitive, new solutions and perspectives, including varietal renovation, are now needed in addition to the already well-established Italian table-grape production lines consisting of conventional open-field cultivation and greenhouse cultivation. One of these new perspectives is represented by the development of table-grape soil-less cultivation systems (TGSC) under greenhouse. In fact, TGSC systems are alleged to offer many advantages in terms of the advancement of berry maturity, extreme varietal flexibility, easier manipulation of the vegetative–reproductive cycle, higher yields of high quality extra-seasonal production, higher sustainability for reduced pesticides application, and higher use efficiency of water and fertilizers than conventional (soil-grown) cultivation. They can be also useful for overcoming soil- and rootstock-related problems. In this review, the opportunities offered by the recently developed table-grape soil-less cultivation systems are thoroughly examined and updated to the latest experimental and application findings of the sector’s research activity. A special emphasis is given to the evolution of the applied technical solutions, varietal choice, and environmental conditions for the aims of table-grape soil-less cultivation.