bluuebunny/crossref_metadata_2025 huggingface dataset:
Performance of prognostic scoring systems in patients with COVID-19 interstitial pneumonia in Acute Medical Unit
Authors: Accordino Silvia , Cazzaniga Massimo , Sozzi Fabiola , Assandri Roberto , Lauria Giuseppe , Canetta Ciro
Published: June 2021

Background: The early detection of COVID-19 patients with interstitial
pneumonia at high risk of dismal outcome is necessary to deliver proper
care and optimize management of limited resources. Objective: The aim of
this study was to analyse the performance of pre-existing scores in
predicting in-hospital mortality and ICU transfer at admission in an
Acute Medical Unit. Methods: 106 consecutive patients with acute
respiratory failure due to COVID-19 interstitial pneumoni admitted to
Acute Medical Unit were enrolled. The performances of NEWS, SIRS, RAPS,
REMS, qSOFA, APACHE II, CURB-65 and PSI were analysed by the Area Under
the Receiver Operator Characteristic (AUROCs) and standard indices of
accuracy. Results: Considering in-hospital mortality PSI and APACHE II
had the higher AUROCs, 0.83 (95% CI 0.75-0.91) and 0.80 (95% CI
0.71-0.88), followed by REMS, 0.77 (95% CI 0.67-0.86), and CURB-65,
0.73 (95% CI 0.63-0.82), whereas the AUROCs of the other scores were
< 0.7. PSI and APACHE II had good sensitivity (0.92 and 0.97),
negative predictive value (0.96 and 0.97) and negative likelihood ratio
(0.1 and 0.1), accurately identifying patients at low risk to die.
However, the low specificity (0.70 and 0.47) and positive likelihood
ratio (3.1 and 1.8) could limit their usefulness in predicting
in-hospital mortality. Considering ICU admissions all the scores, except
NEWS, SIRS and qSOFA, showed a worse performance. Conclusions: PSI and
APACHE II showed good prognostic results in predicting in-hospital
mortality but no pre- existing score validated for acute care settings
was totally satisfactory to predict adverse outcomes in COVID-19
interstitial pneumonia after admission to Acute Medical Unit. The
application setting and selected outcome criteria should always be
considered to evaluate and compare scoring systems’ performance
analysis.
Local inflammation enables a basophil-neuronal circuITCH in atopic dermatitis
Authors: Ehlers Anna , Sanz Celia López , Jimenéz-Saiz Rodrigo
Published: June 2021

Acute itch flares in atopic dermatitis via the LTC4-CysLTR2 pathway.
Endovascular management of symptomatic Deep Vein Thrombosis (DVT) with Combined Approach
Authors: Gallicchio Vito , Barbarisi Danilo , SCIARRILLO Rosaria , Flora Loris
Published: June 2021

The primary goal of this treatment is the restoration of venous outflow
and can be achieved by combined endovascular techniques. We report a
case of 38 years-old female, with leg pain and edema, skin changes,
venous claudication and dyspnea for polmunary embolism.
Exploiting thermodynamic-kinetic synergetic effect for C3H6/C3H8 separation in pillar-layer MOFs
Authors: Chen Yongwei , Wu Houxiao , Yu Liang , Tu Shi , Wu Ying , Li Zhong , Xia Qibin
Published: June 2021

Efficient adsorption separation of propylene (C3H6) and propane (C3H8)
can largely lower the energy consumption compared to the current
energy-intensive cryogenic distillation. Herein, we report an
isoreticular family of pillar-layer metal-organic frameworks (MOFs),
M(AIP)(BPY)0.5 (M = Co, Ni, and Zn), for efficient C3H6/C3H8 separation
by exploiting thermodynamic and kinetic effects, circumventing
disadvantages of each separation mechanism. The three MOFs feature an
open metal site for each metal node and uniform but narrow
one-dimensional (1D) channels, offering strong binding sites toward C3H6
via π-complexations while obstructing the diffusion of bulkier C3H8. The
Ni-MOF shows the best separation performance based on the highest
thermodynamic and kinetic C3H6/C3H8 selectivity, further verified by
computational simulations. Ni(AIP)(BPY)0.5 has a moderate C3H6 uptake of
1.94 mmol/g but a remarkably high C3H6/C3H8 uptake ratio of 4.26 at 298
K and 1 bar. Efficient C3H6/C3H8 separation, good recyclability,
moisture and water stability of Ni(AIP)(BPY)0.5 are confirmed.
Apple Watch facilitates single-session catheter ablation of coexisting atrioventricular nodal reentrant tachycardia (AVNRT) and atrioventricular reentrant tachycardia (AVRT)
Authors: Kasai Yuhei , Kasai Jungo , Sekiguchi Yukio , Asano So , Fukunaga Hiroshi , Nagase Takehiko , Nitta Junichi
Published: June 2021

We report a case of a 52-year old patient complaining of palpitations
and syncope. His heart rate trends from his Apple Watch SE suggested two
types of tachycardia, and we successfully performed ablation for both of
them in a single session. Our case demonstrates the cardiological
potential of smart watches.
Early-onset ischaemic stroke in a patient with the novel F2 c.1824C>T gene variant and PAI-1 4G/4G, MTHFR 677TT genotype
Authors: Pruner Iva , Dincic Evica , Gvozdenov Maja , Tomic Branko , Kovac Mirjana , Djordjevic Valentina
Published: June 2021

Introduction. Ischemic stroke (IS) is a heterogeneous dis-order caused by several genetic and environmental risk factors. It was suggested that coagulation disorders cause 1-4% of cases with IS, especially in patients with early onset of IS. Case report. We describe a case of a young adult male who developed an unprovoked IS. Biochemical, immunological, and thrombophilia screening, as well as DNA sequencing, were performed in order to reveal molecular pathology underlying the stroke of the patient. Thrombophilia testing showed that patient was a homozygous carrier for PAI-1 4G/5G and MTHFR C677T mutations. Additional genetic analysis revealed the presence of the recently reported F2 c.1824C>T gene variant, located in the last exon of the pro-thrombin gene and has previously been shown to cause hy-perprothrombinemia, hypofibrinolysis, and altered fibrin clot phenotype. Conclusion. Our results suggest that the newly reported F2 c.1824C>T gene variant might have a synergistic effect with PAI 4G/4G and MTHFR 677TT genotype in the formation of altered fibrin clot phenotype characterized by thin, densely packed fibrin fibers, which makes clot less susceptible to fibrinolysis and greatly in-creases the risk for early ischemic stroke onset.
Reappearance of C-Peptide During the Third Trimester of Pregnancy in Type 1 Diabetes: Pancreatic Regeneration or Fetal Hyperinsulinism?
Authors: Meek Claire L. , Oram Richard A. , McDonald Timothy J. , Feig Denice S. , Hattersley Andrew T. , Murphy Helen R.
Published: June 2021

OBJECTIVE

We assessed longitudinal patterns of maternal C-peptide concentration to examine the hypothesis of β-cell regeneration in pregnancy with type 1 diabetes.

RESEARCH DESIGN AND METHODS

C-peptide was measured on maternal serum samples from 127 participants (12, 24, and 34 weeks) and cord blood during the Continuous Glucose Monitoring in Women With Type 1 Diabetes in Pregnancy Trial (CONCEPTT). C-peptide was measured using a highly sensitive direct and solid-phase competitive electrochemiluminescent immunoassay.

RESULTS

Three discrete patterns of maternal C-peptide trajectory were identified: pattern 1, undetectable throughout pregnancy, n = 74 (58%; maternal C-peptide <3 pmol/L); pattern 2, detectable at baseline, n = 22 (17%; maternal C-peptide 7–272 pmol/L at baseline); and pattern 3, undetectable maternal C-peptide at 12 and 24 weeks, which first became detectable at 34 weeks, n = 31 (24%; maternal C-peptide 4–26 pmol/L at 34 weeks). Baseline characteristics and third trimester glucose profiles of women with pattern 1 and pattern 3 C-peptide trajectories were similar, but women in pattern 3 had suboptimal glycemia (50% time above range) at 24 weeks’ gestation. Offspring of women with pattern 3 C-peptide trajectories had elevated cord blood C-peptide (geometric mean 1,319 vs. 718 pmol/L; P = 0.007), increased rates of large for gestational age (90% vs. 60%; P = 0.002), neonatal hypoglycemia (42% vs. 14%; P = 0.001), and neonatal intensive care admission (45% vs. 23%; P = 0.023) compared with pattern 1 offspring.

CONCLUSIONS

First maternal C-peptide appearance at 34 weeks was associated with midtrimester hyperglycemia, elevated cord blood C-peptide, and high rates of neonatal complications. This suggests transfer of C-peptide from fetal to maternal serum and is inconsistent with pregnancy-related β-cell regeneration.
COVID-19 and Type 1 Diabetes: Addressing Concerns and Maintaining Control
Authors: DiMeglio Linda A.
Published: June 2021

The worldwide outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been an unprecedented pandemic. Early on, even as the signs and symptoms of coronavirus disease 2019 (COVID-19) were first characterized, significant concerns were articulated regarding its potential impact on people with chronic disease, including type 1 diabetes. Information about the basic and clinical interrelationships between COVID-19 and diabetes has rapidly emerged. Initial rapid reports were useful to provide alerts and guide health care responses and initial policies. Some of these have proven subsequently to have durable findings, whereas others lacked scientific rigor/reproducibility. Many publications that report on COVID-19 and “diabetes” also have not distinguished between type 1 and type 2 (1). Available evidence now demonstrates that people with type 1 diabetes have been acutely affected by COVID-19 in multiple ways. This includes effects from limited access to health care, particularly during lockdown periods, and increased morbidity/mortality in infected adults with type 1 diabetes compared with peers without diabetes.
Islet Autoimmunity and HLA Markers of Presymptomatic and Clinical Type 1 Diabetes: Joint Analyses of Prospective Cohort Studies in Finland, Germany, Sweden, and the U.S.
Authors: Anand Vibha , Li Ying , Liu Bin , Ghalwash Mohamed , Koski Eileen , Ng Kenney , Dunne Jessica L. , Jönsson Josefine , Winkler Christiane , Knip Mikael , Toppari Jorma , Ilonen Jorma , Killian Michael B. , Frohnert Brigitte I. , Lundgren Markus , Ziegler Anette-Gabriele , Hagopian William , Veijola Riitta , Rewers Marian
Published: June 2021

OBJECTIVE:
To combine prospective cohort
studies, by including HLA harmonization, and to estimate risk of islet
autoimmunity and progression to clinical diabetes.

RESEARCH
DESIGN AND METHODS: Prospective cohorts in Finland, Germany, Sweden and the US
have followed 24,662 children at increased genetic risk for development of
islet autoantibodies and type 1 diabetes. Following harmonization, the outcomes
were analyzed in 16,709 infants-toddlers enrolled by age 2.5 years.

RESULTS:
In
the infant-toddler cohort, 1413 (8.5%) developed at least one autoantibody
confirmed at two or more consecutive visits (seroconversion),
865 (5%) developed multiple autoantibodies, and 655 (4%) progressed to
diabetes. The 15-year cumulative incidence of diabetes varied in children with
one, two or three autoantibodies at seroconversion: 45% (95% CI
40-52%), 85% (78-90%), and 92% (85-97%), respectively. Among those with single
autoantibody, their status two years after seroconversion predicted diabetes
risk: 12% (10-25%) if reverting to autoantibody negative, 30% (20-40%) if
retaining single autoantibody, and 82% (80-95%) if developing multiple
autoantibodies. HLA-DR-DQ affected the risk of confirmed
seroconversion and progression to diabetes in children with stable single
autoantibody. Their 15-year diabetes incidence for higher
vs. lower risk genotypes was 40% (28-50%) vs. 12% (5-38%). The rate of progression to
diabetes
was inversely related to age at development of multiple autoantibodies ranging
from 20%/year to 6%/year in children developing multi-positivity ≤2 years or
>7.4 years, respectively.

CONCLUSIONS: The
number of islet autoantibodies at seroconversion reliably predicts 15-year type
1 diabetes risk. In children retaining single autoantibody, HLA-DR-DQ genotypes
can further refine risk of progression.
The High-Risk Type 1 Diabetes HLA-DR and HLA-DQ Polymorphisms Are Differentially Associated With Growth and IGF-I Levels in Infancy: The Cambridge Baby Growth Study
Authors: Eleftheriou Antigoni , Petry Clive J. , Hughes Ieuan A. , Ong Ken K. , Dunger David B.
Published: June 2021

OBJECTIVE

This study explored
the link between HLA polymorphisms that predispose to type 1 diabetes and birth
size, infancy growth and/or circulating IGF-1 in a general population-based
birth cohort.

RESEARCH
DESIGN AND METHODS

The
Cambridge Baby Growth Study is a prospective observational birth cohort study that
recruited 2,229 newborns for follow-up in infancy. Of these, 612 children had DNA available for
genotyping single nucleotide polymorphisms in the HLA region that capture the
highest risk of type 1 diabetes: rs17426593 for DR4, rs2187668 for DR3
and rs7454108 for DQ8. Multivariate
linear regression models at critical ages (cross-sectional) and mixed-effects
models (longitudinal) were performed under additive genetic effects to test for
associations between HLA polymorphisms and infancy weight, length, skinfold
thickness (indicator of adiposity), and concentrations of IGF-1 and IGF-binding
protein-3 (IGFBP-3).

RESULTS

In
longitudinal models, the minor allele of rs2187668 tagging DR3 was associated
with faster linear growth (P=0.007), more pronounced in boys (P=3x10-7) than girls (P=0.07),
and with increasing IGF-1 (P=0.002)
and IGFBP-3 (P=0.003) concentrations in infancy. Cross-sectionally, the minor alleles of rs7454108
tagging DQ8 and rs17426593 tagging DR4 were respectively
associated with lower IGF-1 concentrations at age 12 months (P=0.003) and greater skinfold thickness at
age 24 months (P=0.003).

CONCLUSIONS

The
variable associations of DR4, DR3 and DQ8 alleles with
growth measures and IGF-1 levels in infants from the general population could
explain the heterogeneous growth trajectories observed in genetically at-risk
cohorts. These findings could suggest distinct
mechanisms involving endocrine pathways related to the HLA-conferred type 1 diabetes
risk.
Effect of sheet thickness on the fusion zone temperature distribution, melt pool dimensions, mechanical properties, and microstructure in laser welding of Ti6Al4V alloy
Authors: Khdair Adnan I. , Hader Montasir , Abushgair Khaleel , Khrais Samir
Published: June 2021

Generally, sheet thickness plays a significant role in the selection of appropriate process parameters in order to produce high quality weld joint in the laser welding process. The heat sink capacity and weld penetration are known as two criteria that are mainly influenced by sheet thickness. In this study, the effect of sheet thickness, welding speed, nozzle distance, and laser power were investigated in order to determine the temperature distribution near the melt pool, dimensions of molten pool through experimental and numerical analysis. The weld joint mechanical characterization was determined via elongation rate and tensile strength. The highest value of tensile strength is about 80% of the typical base metal and the elongation of the welded samples achieved about 40% of the base metal. The thinner sheets showed more sensitivity related to the elongation of the joint by increasing the welding speed. Also, the temperature rise with increasing laser power near the melt pool for the thinner sheet was about 200 °C in comparison to the 3 mm sheet, which is about 90 °C. The obtained simulation results for the maximum temperature discrepancy at near the melt pool was 12 °C and 4 °C for 1 and 3 mm thickness orderly, which depicts good agreement with the temperature experimental results.
Sikkerhetspolitisk minnediplomati: Opprettelsen av Frigjøringsmonumentet i Kirkenes 1945–1952
Authors: Aalmen Markussen Joakim
Published: June 2021

Abstract: Security Policy and Memory Politics: Establishing the Soviet Liberation Monument in Kirkenes, 1945–1952A few kilometers from the border with Russia, in the town of Kirkenes in the easternmost corner of Northern Norway, there stands a bronze statue of a Soviet soldier looking out over the borderland. The Soviet Liberation Monument, as the statue is called, was unveiled in 1952 by the Norwegian authorities, in gratitude for the Soviet liberation of the East Finnmark area in 1944. The statue has served as a meeting place for regular commemorative ceremonies involving the Norwegian and Soviet authorities, throughout the Cold War and up until the present. This article explores the interplay between security policy and memory politics at the onset of the Cold War by examining the seven-year long process of establishing this monument. As the Iron Curtain descended over Europe, the monument and the memories attached to it became important tools with which Norway developed a critical dialogue with its great-power neighbor. The article shows how the Norwegian Ministry of Foreign Affairs learned how to use the collective memories of the Soviet liberation to ensure Norway’s security-policy goal of low tension in its relations with the USSR.
Freud: contribuições do estudo da palavra
Authors: Rios Cleusa
Published: June 2021

Entrevista com Cleusa Rios Passos, professora titular da Faculdade de Filosofia Letras e Ciências Humanas da Universidade de São Paulo, que tem experiência na área de Letras, com ênfase em Teoria Literária, atuando principalmente nos seguintes temas: Guimarães Rosa, estudo das formas narrativas e confluências entre crítica literária e psicanálise. Desde 2005, coordena (com outro docente) o grupo de pesquisa "Crítica Literária e Psicanálise". Entrevista: Elisabeth CardosoEdição: Ana Paula Rodrigues da Silva, Thiago Fonseca (TV-PUC)Música: PIPA estúdio
Іnvestigation of gel formation peculiarities and properties of hydrogels obtained by the structuring of acrylamide prepolymers
Authors:   Lviv Polytechnic National University, Maikovych O. V. , Dron I. A. ,   Lviv Polytechnic National University, Bukartyk N. M. ,   Lviv Polytechnic National University, Bordeniuk O. Yu. ,   Lviv Polytechnic National University, Nosova N. G. ,   Lviv Polytechnic National University
Published: June 2021

The paper represents the results of the investigation of the formation of a polymeric matrix of hydrogel due to the structuring of polyacrylamide using its reactive polymeric derivative – poly-N- (hydroxymethyl) acrylamide. Research determined zones of optimum conditions of synthesis and characterized hydrogel depending on pH of media, the ratio between the concentration of prepolymers, and time of synthesis. The investigation of the reaction mixture showed that the hydrogen index of the synthesis of hydrogels is one of the important factors, which in the design of the polymer framework of hydrogels allows regulating their colloidal chemical properties in a wide range.
Modified polyvinyl chloride composites with metal-containing polymer-silicate fillers
Authors:   Lviv Polytechnic National University, Masyuk A. S. , Katruk D. S. ,   Lviv Polytechnic National University, Levytskyi V. Ye. ,   Lviv Polytechnic National University
Published: June 2021

The influence of the nature of the metal-containing polymer-silicate fillers on morphology, surface hardness, Vicat softening point and elastic-plastic properties of PVC plasticates has been researched. The influence of polymer-silicate fillers on physic-mechanical and thermal properties and the conditions directional regulation of technological and operational properties of modified composites has been established.
Synthesis of phosphorus-containing pseudopoliamino acids of polyester type
Authors:   Lviv Polytechnic National University, Stasiuk A. V. , Prychak S. P. ,   Lviv Polytechnic National University, Fihurka N. V. ,   Lviv Polytechnic National University, Varvarenko S. M. ,   Lviv Polytechnic National University, Samaryk V. Y. ,   Lviv Polytechnic National University
Published: June 2021

The method of obtaining phosphorus-containing polyester by the Steglich reaction is considered. The results of studies on the production of polyesteresters using ethyl phosphate group in the structure of dipolyethyleneglycolethylphosphate are presented. The obtained polymer was characterized by IR and 1H NMR spectroscopy. The composition of polyester ether was evaluated and its end groups were analyzed.
Selected Macroeconomic Variables and Agricultural Sector in Nigeria
Authors: Ese Ighoroje James , Ogheneovo Orife Catherine,
Published: June 2021

The study investigated effect of selected macroeconomic variables on agricultural sector output in Nigeria from 1987 - 2019. Annual Agricultural Output (AAO) represented the dependent variable for the study while gross domestic product, interest rate, money supply, and exchange rate represented the explanatory variables. Ex-post factor research design was employed for the study. Augmented Dickey Fuller Unit Roots test and Ordinary Least Square (OLS) Regression techniques were used to analyze data collected. The empirical investigation showed that gross domestic product as well as money supply has a positive and significant effect on agricultural output, while interest rate and exchange rate exerted a negative and insignificant effect on agricultural output. From the study, selected macroeconomic variables have positive effect on agricultural output in Nigeria and this has tremendously contributed to the country's growth and development. The study recommends amongst other; that government should accelerate the rate of economic growth by investing heavily on the agricultural sector so as to boost domestic production and enhance exportation in order to stabilize exchange rate while curbing inflation; give incentives to banks extending agricultural loans by lowering the lending rate on agricultural loans to ease access to funds for agricultural investment.
AUDIT ENERGI PROSES PENGOLAHAN TEH HITAM (CTC) DENGAN SISTEM PENGAMBILAN KEPUTUSAN METODE SPACE
Authors: Ramanda Muhammad Rizky , Nurjanah Sarifah , Widyasanti Asri
Published: June 2021

The favorite product of black tea is tea leaf that are ground using the crush, tear and curl (CTC) method. This process able to produce the dry tea which has high quality with a strong aroma and taste, and high levels of antioxidants. This study aimed to conduct an energy analysis on the processing of black tea CTC at PTP. Nusantara VIII Rancabali to find out the steps towards efficient use of energy, opportunities and conservation efforts. The research method used is descriptive analysis method. The present paper conducted the energy audit calculations which are based on the energy consumption in each tea processing activity from the time. The calculation of energy audit was conducted from preparation of raw materials until the packaging of tea product. The results of the energy audit on the CTC black tea processing showed that for each ton of tea leaves required the energy is about 3.930,66 MJ.ton-1The greatest energy use is drying process which is at 1.424,67 MJ.ton-1 or 36,24%. The results of the analysis space was at quadrant conservative aggressive. Aggressive conservative steps that can be taken in the black tea processing are to develop activities towards energy saving, such as changing fuel from ordinary wood to wood pellets and adding or modifying machine tools so that the installed capacity of each processs to fulfill the capacity input of leaf tea. Key words: CTC, energy analysis, energy saving, processing of tea
Experimental study of shear deformation of the medium formed by the massif of ribbed grains
Authors: Mykulyak S.V. , Polyakovskyi V.O. , Skurativskyi S.I.
Published: June 2021

The approach to the study of the seismically active zone as an open system that is in a state of self-organized criticality is becoming increasingly used in modern research. The models used in this approach should reflect the most characteristic features of such media: discreteness, nonequilibrium, nonlinear and nonlocal nature of interactions. In this paper, the medium is modeled by a granular massif with ribbed grains. Three different massifs are used in the research. Within one massif, all grains are identical, while grains from different massifs differ in shape (cubic or irregular ribbed) and characteristic size.

A number of experiments of shear deformation of such granular massifs were carried out in order to study the influence of the shape and size of grains on the statistical charac-teristics of the process. The influence of the stress state on the deformation properties of these media was also studied. The experiments proved the qualitative similarity of the behavior of different granular media. Obtained experimentally force jumps, represen-ting the reaction of the granular medium to shear deformation, obey the distributions in the form of power dependencies. However, the magnitudes of the forces arising in the massifs depend on the grain shape and size as well as the stress state in the massifs. The experiments with shear deformation of the granular media under the external action of small impulse stresses have shown that such action causes a smoother, devoid of sharp jumps, deformation. External perturbations shift the distribution of the force jumps towards smaller values, leaving their exponents unchanged.

The analysis of experimental results using nonadditive statistical mechanics confirmed the presence of long-range correlations in the massif of ribbed granules during its shear deformation.
Degradation and cell toxicity of new nanofibrous materials for tissue engineering
Authors: Hapchenko A.
Published: June 2021

Biodegradable materials are promising for the development of tissue engineering constructions. At the same time, they must have a satisfactory weight loss profile, no toxicity and the ability to support cell proliferation. Polylactides and their derivatives are intensively used to reconstruct tissues and organs and in drug delivery systems, but the technology of manufacturing materials is not standardized. Electrospinning is an affordable technology that can be used to create three-dimensional nanofiber structures for tissue engineering and regenerative medicine, but their use is currently limited due to insufficient study. The aim. Creation of three-dimensional structures from polylactic acid, evaluation of their biodegradation profile, and cellular toxicity in the model of dermal fibroblasts. Material and methods. Nanofiber membranes were obtained by standard electrospinning and using NanoMatrix3D technology. The degradation study was performed in SBF solution in static and dynamic modes to determine the percentage of weight loss. Cytotoxicity studies were performed on primary dermal fibroblast culture with assessment of resazurin reduction and DAPI imaging. Conclusions. The use of electrospinning technology allows us to create nanofiber membranes that are capable of biodegradation and have a satisfactory toxicity profile. The dynamic system of degradation leads to an increase in a mass loss by membranes due to the removal of degradation products. The data indicate the possibility of using PLA-based materials for the development of structures for tissue engineering.
VARIATIONS OF FEED AMOUNT AND DIFFERENT TEMPERATURES ON THE DEVELOPMENT OF BSF LARVAE DURING FOURTEEN DAYS OF REARED
Authors: Haryanto Trisno , Setiyono Eko
Published: June 2021

Pertumbuhan larva Black Soldier Fly/BSF secara optimal dapat berlangsung selama 14 hari dengan kualitas dan kuantitas makanan yang ideal. Siklus hidup BSF dipengaruhi oleh media pakan dan temperatur. Sehingga penelitian ini bertujuan untuk mengetahui pengaruh variasi pemberian pakan dan temperatur terhadap perkembangan larva BSF. Penelitian menggunakan rancangan acak lengkap (RAL) faktorial dengan variasi komposisi pakan (100; 150; dan 200 mg/larva/hari) dan kombinasi temperatur dengan variasi 25oC; 27oC; 30oC: 35oC). Setiap perlakuan diulang sebanyak 3 kali sehingga ada 36 unit percobaan. Data dianalisis mengunakan uji Kruskal Wallis pada taraf signifikansi 95%. Hasil penelitian menunjukkan pertambahan bobot dan panjang larva secara bertahap dipengaruhi oleh variasi jumlah pakan dan temperatur (P<0,05). Penambahan panjang dan bobot larva sangat berhubungan dengan adanya variasi jumlah pakan dan temperatur yang diberikan dalam perlakuan. Variasi jumlah pakan dan temperatur mempengaruhi perkembangan larva BSF (P<0,05). Dengan demikian dapat disimpulkan bahwa variasi jumlah pakan dan temperatur mempengaruhi perkembangan larva BSF.
ACTIVITY ETHANOL EXTRACT, ETHYLE ACETATE FRACTION, N-HEXAN FRACTION OF SOFO-SOFO LEAVES (Acmella cf) Against Propionibacterium acnes AND Staphylococcus epidermidis AS ANTIBACTERIES
Authors: Marbun Eva Diansari , Sapitri Alfi , Asfianti Vivi
Published: June 2021

Sofo-sofo leaves are traditional medicinal plants that have been known by the Nias people to cure fever, coughs, diarrhea and antimicrobial infections on the skin surface. The  purpose  of  this  study  was  to determine the antibacterial activity of ethanol extract, n-hexane fraction and ethylacetate fraction Sofo-sofo leaf (Acmella cf) against Propionibacterium acnes and Staphylococcus epidermidis. Simplicia powder was characterized and phytochemical screening was performed. Furthermore, it was isolated using 96% ethanol solvent and fractionated with  n-hexane and ethylacetate to obtain extracts. Then test the antibacterial activity of each extract against Propionibacterium acne and Staphylococcus epidermidis by using a diffusion method disc paper. The research results obtained water content 5.66%, water soluble extract content 27.33%, ethanol soluble extract content 13.61%, total ash  content 14.39%, and  acid insoluble ash content 6.25%. The highest antibacterial activity was given by ethylacetate extract at a concentration of 2% (23.4 ± 0.2) compared to ethanol extract with a concentration of 2% (21.06 ± 0.85) and 2% concentrated n-hexane extract (19.36 ± 0.16) against the Propionibacterium acne bacteria. The highest antibacterial activity was ethyl acetate extract at a concentration of 2% (23.24 ± 0.23), ethanol extract with a concentration of 2% (16.36 ± 1.76) and n-hexane extract at a concentration of 2% (15.36 ± 0 , 11) against Staphylococcus epidermidis bacteria. The  antibacterial activity results were analyzed by the one way ANOVA test method. Based on these results it can be concluded that there are differences between treatment groups, which is indicated by a significant value <0.05.
Increasing the information competence of teachers in Yakutia rural schools through professional development courses
Authors: Alekseeva Galina Ivanovna , Sivtsev Mikhail Petrovich , Pavlov Nyurgun Mikhailovich , Barakhsanova Polina Olegovna , Nogovitsyn Roman Romanovich
Published: June 2021

The research goal is to consider the process of developing the information competence of teachers in rural schools in Yakutia required for remote teaching during the pandemic. The main research methods are the method of expert assessments and statistical processing of quantitative research results. Over 600 teachers from 32 uluses of the republic took part in the experiment and did the professional development courses. The overwhelming majority of schools in Yakutia are rural (over 70%), since they are located in rural settlements. The authors devised the teaching methodology for increasing the information competence of teachers in rural schools. The proposed approach implies the continuity of professional development courses. The survey conducted among teachers conclusively demonstrates the need to take into account the specifics of the educational environment of rural schools while developing the information competence of teachers during the pandemic.
PERAN TAMPILAN PRODUK, KEAMANAN DAN KEMUDAHAN PADA KEPUTUSAN BERTRANSAKSI MENGGUNAKAN JASA PENGIRIMAN SHOPEE
Authors: Dewi Septiana Novita , Aris Tri Haryanto
Published: June 2021

Abstract

This research aimed to test and analyze the role of product display, security and ease of transaction decisions using Shopee's shipping services. This research was conducted in the Surakarta area. The object of this research is consumers who have transacted using the Shopee application. The population in this study were consumers who had shopped using the Shopee application who had made transactions at the end of 2019. The sample determination process was carried out based on consumer experience in using the Shopee application. Furthermore, it was ensured that the consumers who were the samples of this study met the specified criteria and were willing to fill out the questionnaire. If they were not willing and do not meet the criteria, then the consumer was skipped and then  researcher looked for other consumers who met the sample criteria. By using this technique, not all populations in this study had the same opportunities as research samples. In this study the sample was 56 respondents. This study resulted in a regression equation, it can be seen that product appearance, security and convenience have a positive effect on the decision to transact using Shopee's shipping services. The results of the t-statistical test show that product appearance, security and convenience partially have a significant effect on the decision to transact using Shopee's delivery service

 Keywords: Product Display, Security and Ease, Transaction Decision.
THE EFFECT OF TAX MINIMIZATION, BONUS MECHANISM, FOREIGN OWNERSHIP, EXCHANGE RATE, AUDIT QUALITY ON TRANSFER PRICING DECISIONS
Authors: Marfuah Marfuah , Sanintya Mayantya  , Priyono Puji Prasetyo
Published: June 2021

Abstract

The purpose of this study was to determine the effect of tax minimization, bonus mechanisms, foreign ownership, exchange rates, and audit quality on transfer pricing in manufacturing companies in Indonesia. The population of this research was all manufacturing companies listed on the Indonesia Stock Exchange from 2017 to 2019. By using the purposive sampling method, 81 companies were selected as the research sample. Based on logistic regression analysis, it was proven that the tax minimization variable has a significant positive effect on transfer pricing decisions. Likewise, the audit quality variable is proven to have a significant negative effect on transfer pricing decisions in manufacturing companies in Indonesia. Meanwhile, the bonus mechanism, foreign ownership, and exchange rate variables were not proven to have a significant effect on the company's transfer pricing decision. These results indicated that the greater the tax minimization carried out by the company and the lower the audit quality will increase the probability of the company in conducting transfer pricing, and vice versa. The results of this study have implications for encouraging the government to make regulations that can prevent transfer pricing practices between companies that have a special relationship that might harm the government from tax revenue.

 Keywords: bonus mechanism; foreign ownership; tax minimization; transfer pricing
EXPERIENCE OF APPLICATION OF MODERN METHODS AND TECHNOLOGIES IN FORMATION OF ABILITY TO USE NAVIGATION EQUIPMENT OF INTEGRATED CURRENT
Authors: Danylenko Oleksandr
Published: June 2021

The relevance of the problem proposed in the publication is that the use of modern methods and technologies in the training of future drivers is directly related to the quality of this training. The author justifiably reveals the importance of training technologies not only in the training of future drivers, but also on a national scale, analysing the relevant regulations adopted in Ukraine, as well as organizations of international level. The article analyses the specific terminology related to the maritime industry («bridge», «integrated bridge»), the functions of the captain on the integrated bridge, in order to obtain reliable and complete information. The main research methods applied: search and bibliographic, content analysis, which were used to study the etymology of the main categories of the problem. Based on the analysis of psychological-pedagogical and engineering-technical literature, the content of the basic concepts of the research is determined, the theoretical substantiation of their essential characteristics is carried out. The relationship between the concepts of «simulator», «simulation» in terms of the organization of professional training of future drivers in higher education. The classification of training technologies with specific examples of their application is presented. The result of the study is the justification of the feasibility of using mixed training technologies in the formation of the ability to use navigation equipment by future drivers on the integrated bridge. The conclusions are formulated on the use of simulators in the formation of the ability to use navigation equipment by future navigators and promising areas of further research.
COMPARATIVE STUDY OF THE CIVIL SOCIETY ORGANIZATIONS AT THE NATIONAL LEVEL AND IN CARPATHIAN REGION OF UKRAINE
Authors: Zhylenko Ruslan
Published: June 2021

The study aims to compare CSOs at the national and regional (Ukrainian part of Carpathian Euroregion) levels for possible disparities. It is mainly based on the results of secondary analysis of available official statistical and fiscal data, as well as those published in the study reports. In particular, there were analyzed the Bulletins «Activity of the Civic Associations in Ukraine» and «Indicators of United State Registry of the Companies and Organizations of Ukraine» published by the State Statistics Service of Ukraine and its regional departments during 2014-2018. Also the quantitative results of studies done by National Institute for Strategic Studies, Corestone Group and GfK Ukraine, CCC Creative Center, and other institutions were examined. Relevance to the problem of research and its regional boundaries has been employed as a main selection criterion for the secondary data used. Civil society organizations (CSOs) perform exceptional role in providing social services to the inhabitants of the Carpathian region of Western Ukraine. However, they operate in a certain environment significantly influencing respectively their sustainability and capacity to offer high quality services. Obviously, the impact of environment differs regionally, creating unequal opportunities for organizations working in diverse parts of the country. This study aimed to compare CSOs at the national and regional (Ukrainian part of Carpathian Euroregion) levels for possible disparities. The author used secondary analysis of available official statistical and fiscal data, as well as data published in the study reports. He argues that despite actually the same legal, fiscal, and political environment, there are remarkable disparities between CSOs at the national and regional levels. These discrepancies are less evident regarding number and type of operating organizations, their fields of activity but are more significant in respect to available funding and its sources, budgets, staff involved, and environment for philanthropy.
COMMUNICATIVE TASKS FOR IMPROVING FOREIGN LANGUAGE SPEAKING COMPETENCE OF PROSPECTIVE TEACHERS
Authors: Lobachova Iryna
Published: June 2021

The article deals with the implementation of communicative exercises in foreign language classes to improve the foreign language speaking competence of prospective teachers. The relevance of the article is determined by the need to consider the outlined problem for increasing the level of English language proficiency in order to personal and career prospects of prospective teachers. The purpose of the article is a theoretical and practical justification for the use of communicative exercises in the study of English in foreign language classes for prospective teachers in higher education. To achieve this goal it is necessary to solve the following tasks: 1) to analyze the efficiency of using communicative tasks to improve students’ foreign language speaking competence; 2) to offer exercises for communication, which provide for the creation of life situations of foreign language communication; 3) to substantiate the efficiency of using these exercises to improve foreign language speaking competence of future teachers. To achieve this purpose the following research methods are used in the scientific article: generalization, analysis and synthesis, descriptive method, which allow to consider in detail the proposed problem and come to important conclusions. It is determined that the specificity of learning a foreign language is to create an artificial language environment, which is absent in practice in most cases. Foreign language space is extremely important for the realization of one of the factors influencing the acquisition of a foreign language – the speed of establishing associative language connections. It is found out that in the communicative environment both the conscious training of vocabulary and grammar, and the necessary language tools accumulate during communicative activities intuitively. The speed of appropriate language reactions, a sense of language are developed in this activity (phonetic, lexical, grammatical aspects). The permanent search for new teaching aids, the development of more effective methods of work are of practical importance for increasing the student’s motivation to learn a foreign language and automate the experience of its using. The proposed types of communication exercises create the most adequate conditions for the formation of language skills, stimulate the mechanisms of involuntary memorization, as well as provide for the solution of certain methodological, linguistic and psychological problems.
SPECIFICS OF PREPARING OF FUTURE PRIMARY SCHOOL TEACHERS FOR THE PROFESSIONAL ACTIVITY IN CONDITIONS OF INCLUSIVE EDUCATION
Authors: Loik Halyna , Vyhrushch Vira , Bryzhak Nadiya
Published: June 2021

Education reform in Ukraine is a necessary condition for the training of highly qualified specialists. This also applies to inclusive education. Modernization and renewal of the educational system of Ukraine is provided through the introduction of new technologies. It is the latest technologies that contribute to the quality training of primary school teachers. A special place in such training is the training of teachers who are able to work in an inclusive environment. The problem of working with children with abnormalities in physiological and physical development is relevant. Its relevance is explained by the fact that in Ukraine an increasing number of children with various disabilities are born. There are many reasons for this, but teachers need to prepare children for life, for professional realization. Their preparation requires specific methods and tools of teaching and education. Therefore, the aim of the study is to identify effective ways of quality training of future teachers to work in an inclusive environment. The following methods were used to study the readiness of future teachers to work in an inclusive environment: theoretical − synthesis, analysis, generalization; empirical - observations, conversations, questionnaires, testing, interviews, surveys, pedagogical experiment (ascertaining and formative); methods of mathematical statistics (Fisher’s F-test). The results of the study are to determine the specifics of the preparation of primary school teachers to work in an inclusive environment to develop ways to improve such training. The further directions of research: improvement of educational programs, development of modern techniques of the personal plan, developing scenarios of various games.
PEDAGOGICAL CONDITIONS FOR THE DEVELOPMENT OF THE ORGANIZATIONAL CULTURE OF THE COLLEGE STUDENT COMMUNITY
Authors: Margitych Agnteta
Published: June 2021

The relevance of the study is determined by the fact that the development and improvement of the experience of spiritual life and spiritual maturation of students is especially important in the period of their professional and personal development, when they are ready to accumulate human experience and master the world in knowledge, values and meanings. The purpose of the article: to substantiate the pedagogical conditions for the development of organizational culture of the college student community in a multicultural environment. To implement the tasks, research methods were used: analysis of documentary and scientific sources – in order to determine the components of the organizational culture of the student community and highlight the properties that characterize the student community as a «collective entity»; systematization and grouping of information material – to identify features of the multicultural educational environment of the college; generalizations – to formulate conclusions. It is determined that the organizational culture of the student community is a subculture of the organizational culture of the college as a whole, which is a system of material and spiritual values, assumptions, beliefs, expectations, norms and patterns of behavior that share and support most students, and define their actions and interactions within and outside the community, in daily activities and future careers. It is emphasized that the formation of the organizational culture of the student community of the college, which carries out educational activities in a multicultural environment, is special. The pedagogical potential of the multicultural educational environment of the college is characterized as a dynamic education, which is characterized by a set of educational, upbringing, communicative and reflective resources, aimed at enriching the spiritual experience of students representing different ethnic, religious and socio-economic groups, their assimilation of general cultural and national values and successful socialization in society. The factors influencing the spiritual enrichment of the student and the organizational culture of the student community are identified: psychological, pedagogical and multicultural.
GENDER FEATURES OF YOUTH'S SENSITIVITY TO THE DESTRUCTIVE INFLUENCE OF SOCIAL INTERNET NETWORKS
Authors: Markova Natalia
Published: June 2021

The rapid growth in the number of users of social networks is the main trend of the modern information society. Unfortunately, information on social media is not always positive. The Internet is increasingly turning into a channel for negative influence on minors, educating them in a spirit of permissiveness and licentiousness, deforming their moral consciousness, contributing to victimization, marginalization and criminalization. And young people, due to their psychological and age characteristics, are sensitive to destructive virtual influences. Therefore, the purpose of the article is to identify and characterize the gender characteristics of the behavior of young people on social Internet networks, and their susceptibility to destructive influences. To achieve the goal of the study, methods of analysis, generalization and systematization of information were used on 58 (29 boys and 29 girls) pages of social network users from among students; conversations and testing to determine susceptibility to destructive influences. The results obtained in the course of the study showed an insignificant difference in the behavior of boys and girls on the Internet and their susceptibility to destructive influences. Young men have a lower level of suggestibility and more criticality to the information received, which makes them difficult objects for destructive influence. The author suggested that young people with a low level of manipulative behavior and a high level of suggestibility are more susceptible to destructive influence, including from the Internet. The author concludes that in order to neutralize the destructive influence of virtual networks in the process of social work in young people, it is necessary to form a number of competencies in the field of media-safe behavior and, above all, sustainable criticality to the negative impact of the destructive segments of modern social networks through a conscious attitude to the information coming from them.