bluuebunny/crossref_metadata_2025 huggingface dataset:
Turismo, geografia e a obra de Rita de Cássia Ariza da Cruz
Authors: Marulo Artur Manuel , Oliveira Elizângela Justino de , Batista Joane Luiza Dantas
Published: November 2021

O presente trabalho tem por objetivo analisar toda a produção bibliográfica da Professora Dra. Rita de Cássia Ariza da Cruz, apontando suas contribuições à construção do conhecimento sobre o turismo, como também o método de que a autora se utiliza para entender o turismo numa perspectiva geográfica. Para tanto, iniciaremos com uma breve introdução a respeito do surgimento do Turismo como curso superior e suas preocupações epistemológicas. Iniciando as reflexões no intuito de atender nosso principal objetivo, no primeiro tópico, apresentaremos a trajetória acadêmica da Professora Rita de Cássia Ariza da Cruz e suas principais obras, incluindo livros publicados e seus mais importantes artigos. Em seguida, realizaremos uma breve discussão a respeito da origem, propostas críticas ao modelo sistêmico, modelo mais utilizado para as análises do turismo, bem como as novas abordagens metodológicas propostas para o turismo, entre elas: a Fenomenologia e a Teoria da Complexidade. Já no terceiro ponto, discutiremos o método dialético como proposta da Professora Rita de Cássia para se entender o turismo. Nas Considerações Finais, apontaremos as principais contribuições da Professora Rita de Cássia ao Turismo, com base na análise da sua produção bibliográfica.
O Turismo sustentável na percepção do viajante Gaúcho
Authors: Silva Natália Gomes da , Monticelli Jefferson Marlon
Published: November 2021

Sustentabilidade é um tema recorrente no século XX. No caso do setor de Turismo, também se mostra uma preocupação, entretanto, verifica-se que não há um consenso sobre o conceito de turismo sustentável. As pesquisas realizadas sobre o tema restringem-se à dimensão dos fornecedores/prestadores de serviço, sendo que o tema foi pouco estudado na perspectiva do cliente/viajante. A partir desta contextualização, este trabalho tem como questões norteadoras: os potenciais clientes dos serviços de turismo estão considerando em suas decisões a questão da sustentabilidade ao planejarem suas viagens turísticas? Os potenciais clientes percebem a sustentabilidade como um diferencial das organizações que atuam no ramo de turismo? O objetivo desta pesquisa foi identificar hábitos relacionados ao comportamento do cliente de viagens a turismo, especialmente com enfoque no turismo sustentável. A metodologia de pesquisa foi o levantamento (survey). Por meio dos resultados, percebe-se que o Turismo Sustentável ainda não é visto de forma clara pelos viajantes e que nem sempre são consideradas atitudes de caráter sustentável quando do planejamento e realização de viagens a turismo.
A gastronomia regional no turismo rural da metade sul do Rio Grande do Sul
Authors: Pinto Leidh Jeane Sampietro , Santos Eurico De Oliveira , Thomé-Ortiz Humberto , Aguirre-González Noe Antonio , Jasper Juliana Rose
Published: November 2021

Na promoção de um destino turístico faz-se necessário conhecer as especificidades de sua configuração, analisando tudo que pode ser empregado para fins turísticos, e entre outros itens está a gastronomia. A alimentação é uma necessidade de sobrevivência e sua improbabilidade de abstenção pelo turista torna a gastronomia indissociável ao turismo. Este trabalho busca a caracterização da gastronomia praticada em algumas propriedades rurais da Metade Sul do Estado do Rio Grande do Sul, com a finalidade de situar a participação dessa no turismo rural desenvolvido nesses locais. A abordagem utilizada nesse estudo foi fundamentada numa pesquisa exploratória, sendo utilizado como procedimentos técnicos o levantamento bibliográfico, bem como a pesquisa de campo que possibilitou a coleta de dados junto aos proprietários. Embora a gastronomia regional possa potencializar a experiência turística, encontrou-se uma cozinha tipicamente rural desatenta as suas iguarias típicas.
QUALIDADE DE VIDA DE PACIENTES QUE RETORNAM A HEMODIÁLISE APÓS SEREM SUBMETIDOS A UM TRANSPLANTE RENAL
Authors: Ramos Fernanda Luiza Soares , Salazar Valdiene Maria dos Santos , Santos Waleska de Lima , Mota Luciana de Melo
Published: December 2021

Introdução: A Doença Renal Crônica (DRC) é caracterizada pela perda gradual e irreversível da função renal, esse fato ocorre quando os rins deixam de remover os produtos metabólicos produzidos pelo corpo ou de realizar sua função reguladora. O transplante renal envolve transplantar o rim de um doador vivo ou falecido para um receptor que não apresenta mais função renal. Objetivo: Avaliar a qualidade de vida de pessoas que retornaram a hemodiálise após transplante renal. Métodos: Pesquisa de abordagem qualitativa, do tipo estudo de caso. Utilizou-se de uma entrevista semiestruturada e o instrumento de avaliação de qualidade de vida da Organização Mundial de Saúde, WHOQOL-100. Foram entrevistados dois pacientes, recrutados por meio do contato com o serviço de Nefrologia onde os mesmos realizavam o tratamento dialítico. Resultados: A entrevista demonstrou que o diagnóstico de rejeição do órgão é um dos momentos mais difíceis para o paciente, a assistência da família durante o tratamento é de fundamental importância, as restrições dietéticas e hídricas tornam-se uma carga a mais durante o tratamento e as expectativas futuras possivelmente serão menores considerando a fase da vida em que esse diagnóstico é constatado. No WHOQOL-100, os entrevistados apresentam níveis iguais ou acima da média de qualidade de vida, sendo apenas o domínio de nível de independência o de menor escore. Conclusão: A pesquisa enfatiza a necessidade de uma atenção profissional humanista e acolhedora, visto que esse retorno a hemodiálise após passar pelo transplante pode ocasionar um impacto negativo nas dimensões físicas, psíquicas e sociais das pessoas que voltam a realizar hemodiálise.
A crise hídrica como reflexo da seca: o Nordeste Setentrional em alerta.
Authors: Bezerra Macio Bento
Published: November 2021

A região Nordeste brasileira tem vivenciado uma das piores secas já registradas nos últimos anos. O presente trabalho tem como objetivo, realizar uma análise acerca da intensidade deste fenômeno, norteado mediante consulta aos níveis pluviométricos registrados nos últimos meses, de modo a apreciar os volumes hidrológicos totais e os armazenados nos reservatórios monitorados pela Agência Nacional das Águas na área objeto deste estudo. De modo a obter tais desígnios, tornou-se necessário a utilização de métodos e técnicas essenciais ao pleno desenvolvimento do trabalho investigativo, dos quais destacam-se o método de abordagem indutivo e o método de procedimento estatístico, bem como, o uso de técnicas de pesquisa constituídas pelas documentações indireta e direta intensiva. Como resultados destacamos os baixos níveis dos recursos armazenados responsáveis pela garantia hídrica da região, fenômeno decorrente dos baixos índices pluviométricos, característicos do longo período de estiagem que assola a região Nordeste do Brasil. Assim, considera-se a necessidade de políticas emergências, das quais objetivem suprir o anseio e a necessidade não só da população, mas de todo ecossistema.
Fatores Condicionantes de Suscetibilidade a Ocorrência de Deslizamentos de Terra nas Rodovias do Maciço de Baturité, Ceará.
Authors: Juvenal Pedro Henrique da Silva
Published: November 2021

O presente artigo propõe analisar os fatores condicionantes de suscetibilidade que contribuem para agravar a vulnerabilidade das pessoas nas rodovias do Maciço de Baturité. Ocasionalmente no período chuvoso ocorrem deslizamentos de terra na área, principalmente devido aos cortes das encostas que bordeiam grande parte das vias, com ausência de contenção. Oferecendo risco aos moradores locais e aos transeuntes, tendo em vista que o Maciço de Baturité é uma importante área turística do Estado do Ceará. Além, disso no artigo foi analisado a disponibilidade de serviços e contingente para socorro e salvamento em caso de emergência na região. Apesar da pesquisa está em fase inicial, foi possível concluir que caso ocorra esses deslizamentos, que geralmente interrompe o tráfego nas rodovias e dificultaria o trabalho do resgate de vítimas. Os resultados serão importantes para elaboração de possíveis planos de contingência de modo que contribua para a conscientização da população e alerte sobre os riscos de deslizamentos de terra as autoridades competentes.
Planejamento Ambiental, Turismo e Sustentabilidade: o potencial natural da Lagoa do Bacuri, Maranhão-Brasil.
Authors: Ribeiro Naiara dos Reis
Published: November 2021

As atividades turísticas ocorrem em porções significativas da superfície terrestre que influenciam e modificam o espaço geográfico. O Maranhão possui um potencial ecoturístico diversificado que abrange desde ambientes como a baixada maranhense até o Delta do Parnaíba. Neste contexto destacamos a Lagoa do Bacuri que possui grande potencial paisagístico, que desperta atração de uma quantidade de visitantes de várias cidades, principalmente da região do Baixo Parnaíba. O ambiente é dotado de belezas naturais, ligadas principalmente ao seu potencial hídrico, vegetal e geomorfológico. Com esta pesquisa busca-se evidenciar as potencialidades naturais para o desenvolvimento do turismo sustentável na Lagoa do Bacuri a partir da análise do potencial natural e dos processos que atuam no ambiente. A pesquisa teve como principais procedimentos metodológicos a pesquisas bibliográficas e cartográficas referentes à área de estudo, e utilização de técnicas de sensoriamento remoto e geoprocessamento para identificação das áreas e jornadas de campo. A lagoa do Bacuri possui potencial natural para desenvolver segmentos do turismo ecoturismo, turismo rural, turismo de aventura e etc. Porém é necessário que haja um interesse mútuo por parte do poder público, das populações da região e da iniciativa privada para o desenvolvimento do turismo local.
Fluorescent Carbon Dots as Prospective Nanoagents for Imaging-assisted
Biomedical Applications
Authors: Phan Le Minh Tu
Published: November 2021

:

Carbon dots (CDs), an emerging nanoagent providing an alternative to conventional
fluorescent agents, are sparking the scientist’s interest in biomedical applications
owing to their unique advantages, including ease of synthesis, large scale production,
low cost, prominent photoluminescence, good photostability, easy functionalization, sufficient
biocompatibility, good nanocarrier, and excellent ability to generate reactive oxygen
species or heat. Herein, this perspective provides a viewpoint about imaging-assisted
biomedical applications using fluorescent CDs regarding in vitro and in vivo bioimaging,
imaging-assisted sensing, and imaging-guided therapy. The opinions about their potential
and challenges in applicable biomedical applications are discussed to develop, further
ameliorated CDs for their intense exploitation in diverse imaging-assisted biomedical applications.
Retinal Degeneration: Molecular Mechanisms and Therapeutic Strategies
Authors: Wu Xue , Yan Naihong , Zhang Ming
Published: November 2021

:

Retinal degenerative diseases are the main retinal diseases that threaten vision.
Most retinal degenerative diseases are inherited diseases, including autosomal recessive
inheritance, autosomal dominant inheritance, X-linked inheritance, and mitochondrial inheritance;
therefore, emerging gene therapy strategies may provide an alternative method
of treatment. Currently, three viral vectors are usually used in gene therapy studies: adenovirus,
lentivirus, and adeno-associated virus. Other gene therapies have their own advantages,
such as DNA nanoparticles, antisense oligonucleotides, and gene editing therapies.
In addition, retinal degenerative diseases are often accompanied by abnormalities of retinal
cells, including photoreceptor and retinal pigment epithelial cells. At present, stem
cell transplantation is a promising new treatment for retinal degenerative diseases. Common
sources of stem cells include retinal progenitor cells, induced pluripotent stem cells,
embryonic stem cells, and mesenchymal stem cells. In addition, retina explant cultures in
vitro can be used as an effective platform for screening new therapies for retinal degenerative
diseases. Drugs that actually reach the retinal layer are more controlled, more consistent,
and less invasive when using retinal explants. Furthermore, studies have shown
that the imbalance of the gut microbiota is closely related to the occurrence and development
of diabetic retinopathy. Therefore, the progression of diabetic retinopathy may be
restrained by adjusting the imbalance of the gut microbiota. The purpose of this review is
to discuss and summarize the molecular mechanisms and potential therapeutic strategies
of retinal degenerative diseases.
Polyphenols’ Effect on Cerebrovascular Health
Authors: Goya Luis , Román Ricardo San , de Pascual-Teresa Sonia
Published: November 2021

:

Polyphenols are a wide group of plant components that include a high number
of individual compounds and are present in foods, dietary supplements, and drugs. Many
of them have shown pharmacological effects, are used in cardiovascular disease prevention,
and not as many have been assayed in cancer treatment or co-treatment. In the last
few years, however, the research on polyphenols' implications in healthy aging, especially
in neurodegeneration and cognition improvement, has increased dramatically. Most of
the results found in this sense are again related to the capacity of some specific polyphenols
to regulate the blood flow, but this time at the cerebral level, and to protect the
endothelium at this same level. In this thorough review, we want to concentrate precisely
on the effect of polyphenols on cerebrovascular homeostasis, reviewing the mechanisms
that underline this effect and the radiological methods and endogenous biomarkers that
are used in human trials aimed at showing the beneficial effect of polyphenols or polyphenol
rich foods on neuroprotection and cognition function.
Oligonucleotides Carrying Nucleoside Antimetabolites as Potential
Prodrugs
Authors: Fàbrega Carme , Clua Anna , Eritja Ramon , Aviñó Anna
Published: November 2021

Background:

Nucleoside and nucleobase antimetabolites are an important
class of chemotherapeutic agents for the treatment of cancer as well as other diseases.

Introduction:

In order to avoid undesirable side effects, several prodrug strategies have
been developed. In the present review, we describe a relatively unknown strategy that
consists of using oligonucleotides modified with nucleoside antimetabolites as prodrugs.

Method:

The active nucleotides are generated by enzymatic degradation once incorporated
into cells. This strategy has attracted large interest and is widely utilized at present
due to the continuous developments made in therapeutic oligonucleotides and the recent
advances in nanomaterials and nanomedicine.

Results:

A large research effort was made mainly in the improvement of the antiproliferative
properties of nucleoside homopolymers, but recently, chemically modified aptamers,
antisense oligonucleotides and/or siRNA carrying antiproliferative nucleotides have demonstrated
a great potential due to the synergetic effect of both therapeutic entities. In addition,
DNA nanostructures with interesting properties have been built to combine antimetabolites
and enhancers of cellular uptake in the same scaffold. Finally, protein nanoparticles
functionalized with receptor-binders and antiproliferative oligomers represent a
new avenue for a more effective treatment in cancer therapy.

Conclusion:

It is expected that oligonucleotides carrying nucleoside antimetabolites will
be considered as potential drugs in the near future for biomedical applications.
Molecular Modeling Techniques Applied to the Design of Multitarget
Drugs: Methods and Applications
Authors: Castro Larissa Henriques Evangelista , Sant'Anna Carlos Mauricio R.
Published: November 2021

:

Multifactorial diseases, such as cancer and diabetes present a challenge for the traditional
“one-target, one disease” paradigm due to their complex pathogenic mechanisms. Although a
combination of drugs can be used, a multitarget drug may be a better choice due to its efficacy, lower
adverse effects and lower chance of resistance development. The computer-based design of these
multitarget drugs can explore the same techniques used for single-target drug design, but the
difficulties associated with the obtention of drugs that are capable of modulating two or more targets
with similar efficacy impose new challenges, whose solutions involve the adaptation of known
techniques and also to the development of new ones, including machine-learning approaches. In
this review, some SBDD and LBDD techniques for the multitarget drug design are discussed, together
with some cases where the application of such techniques led to effective multitarget ligands.
GreenMolBD: Nature Derived Bioactive Molecules' Database
Authors: Hosen S. M. Zahid , Junaid Md. , Alam Muhammad Shaiful , Rubayed Maruf , Dash Raju , Akter Rasheda , Sharmin Tania , Mouri Nusrat Jahan , Moni Mohammad Ali , Khatun Mahmuda , Mostafa Mohammad
Published: November 2021

Background:

One of the essential resources for developing new drugs are naturally derived
biologically active lead compounds. Biomedical researchers and pharmaceutical companies are
highly interested in these plant-derived molecules to develop the new drug. In this process, collective
information of the plants and their phytoconstituents with different properties and descriptors would
greatly benefit the researchers to identify the hit, lead or drug-like compound.

Aim and Objective:

Therefore, the work intended to develop a unique and dynamic database Green-
MolBD to provide collective information regarding medicinal plants, such as their profile, chemical
constituents, and pharmacological evidence. We also aimed to present information of phytoconstituents,
such as in silico description, quantum, drugability and biological target information.

Method:

For data mining, we covered all accessible literature and books, and for in silico analysis,
we employed a variety of well-known software and servers. The database is integrated by MySQL,
HTML, PHP and JavaScript.

Result:

GreenMolBD is a freely accessible database and searchable by keywords, plant name, synonym,
common name, family name, family synonym, compound name, IUPAC name, InChI Key,
target name, and disease name. We have provided a complete profile of individual plants and each
compound’s physical, quantum, drug likeliness, and toxicity properties (48 type’s descriptor) using
in silico tools. A total of 1846 associated targets related to 6,864 compounds already explored in
different studies are also incorporated and synchronized.

Conclusion:

This is the first evidence-based database of bioactive molecules from medicinal plants
specially grown in Bangladesh, which may help explore and foster nature-inspired rational drug discovery.
Rg1 Promotes the Proliferation and Adipogenic Differentiation of Human
Adipose-Derived Stem Cells via FXR1/Lnc-GAS5-AS1 Pathway
Authors: Mo Steven , Wu Zheng-Qiu , Li Hong-Mian , Xu Fang-Tian , Xu Yin-Li , Rong Yong-Xian , Huang Dong-Lin , Lai Zhong-Hong , Liu Xin-Heng , Yang Ling-Hui
Published: November 2021

Background:

Human adipose-derived stem cells (hASCs) play an important role in regenerative
medicine.

Objective:

Exploring the mechanism of Rg1 in the promotion of the proliferation and adipogenic
differentiation of hASCs is important in regenerative medicine research. Methods: To observe
ginsenoside Rg1 in promoting the proliferation and adipogenic differentiation of hASCs, Rg1 medium
at different concentrations was established and tested using the cell counting kit-8 (CCK-8) assay,
oil red O staining, alizarin red, and alcian blue. Compared to the control, differentially expressed
genes (DEGs) were screened via DEG analysis, which was carried out in the Gene Ontology
(GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses.
To explore the relationship among mRNA, long non-coding RNA (lncRNA) and microRNA (miRNA),
we constructed a competing endogenous RNA (ceRNA) network.

Results:

In this study, Rg1 was observed to promote the proliferation and adipogenic differentiation
of hASCs. Additionally, enriched BPs and KEGG pathways may be involved in the promotion
process, where FXR1 and Lnc-GAS5-AS1 were found to be regulatory factors. The regulatory network
suggested that Rg1 could regulate the adipocytokine signaling pathway and IL−17 signaling
pathway via FXR1 and Lnc-GAS5-AS1, which served as the mechanism encompassing the promotion
of Rg1 on the proliferation and adipogenic differentiation of hASCs.

Conclusion:

A comprehensive transcriptional regulatory network related to the promotion ability
of Rg1 was constructed, revealing mechanisms regarding Rg1’s promotion of the proliferation and
adipogenic differentiation of hASCs. The present study provides a theoretical basis for optimizing
the function of hASCs.
Strategies to improve jump service skills at volleyball student activity unit of Muhammadiyah University of Surakarta
Authors: Jariono Gatot , Nurhidayat Nurhidayat , Nugroho Haris , Nugroho Djoko , Amirzan Amirzan , Budiman Indra Adi , Fachrezzy Fahmy , Sudarmanto Eko , Nyatara Sae Dikdaya
Published: November 2021

The purpose of this study is to analyze and describe strategies to improve jump service in the student activity unit of the University of Muhammadiyah Surakarta. The population and sample in this study were students who participated in the volleyball activity unit as many as 60 people, namely 30 sons and 30 daughters, purposive sampling was used in the selection of samples. This type of research presents descriptive research using a quantitative research type approach. Data analysis techniques use descriptive statistical percentages. Descriptive analysis is the purpose of analyzing and describing the characteristics of this overall data analysis used in the SPSS program version 20.0. The conclusion of this study is a strategy to improve jump service skills in the student activity unit through physical condition training by considering the special preparatory physical condition training program,  pre-competition physical condition training program,  main competition physical condition training program,  transition physical condition training program, and compiling an exercise program. Following the characteristics of the sport of football. However, to determine the exercise program the physical condition needs to be careful, because in this study the sample used is still very little, and the need to consider other variables in conducting further research.
Literature Study: The Effect of Abdominal Massage to Reduce Gastric Residual Volume in Critically Ill Patients
Authors:   Universitas Muhammadiyah Surakarta, Afitasari Adella Indri , Hudiyawati Dian
Published: December 2021

Gastrointestinal dysfunction is one of the most common problems experienced by patients in the ICU, such as abdominal distension, constipation, and increased gastric residual volume. Currently, non-pharmacological interventions have been developed to address these problems. Abdominal massage intervention is considered a method that can improve digestive function. The purpose of this literature study was to determine the effect of abdominal massage to reduce the gastric residual volume in critically ill patients. Selected articles were obtained through online databases such as PubMed, Google Scholar, and ScienceDirect. There were seven articles obtained after going through screening and identified for critical review. There were five study randomized controlled trials, three quasi-experimental designs, one study, one group pre-test post-test, and one article one-shot case study. The results of this study found that abdominal massage was effective in reducing gastric residual volume. Mechanism of abdominal massage with stimulation of peristalsis, changes in intra-abdominal pressure, mechanical and reflexive effects on the intestine, thereby shortening the transition time of food in the intestine, increasing bowel movements, and easier flow of food through the digestive tract. So that nurses in the ICU are expected to use abdominal massage as an intervention option at critical times, considering that this intervention can prevent gastrointestinal dysfunction with low risk and is cost-effective.
Literature Review : Hydrotherapy Reduce Blood Pressure among Hipertensive Clients
Authors:   Universitas Muhammadiyah Kudus, Izzat Yasmina , Jauhar Muhamad , Surachmi Fajar
Published: December 2021

Hypertension is a cardiovascular disease that has been linked to a number of public health issues. This is due to unhealthy lifestyles and cellular and tissue physiological function impairment. Hydrotherapy is a non-pharmacological intervention that can lower blood pressure. As long as the patient is taking antihypertensive medications, this therapy becomes complementary. This study aims to describe the use of hydrotherapy that lowers blood pressure in hypertensive patients. The research design used is a literature review of national and international indexed journals. The databases used include ProQuest, GALE, OneSearch, RAMA, SINTA, and Google Scholar by using keywords hydrotherapy, blood pressure, and hypertension. Inclusion criteria are the range of publication years is in 2016-2020. While the exclusion criteria is when the independent variable used is a combination therapy. Based on a review of ten articles, hydrotherapy affects lowering blood pressure, therefore this therapy can be used as an adjunct therapy to lower blood pressure. This occurs because warm water dilates blood vessels, lowering blood pressure.
Nonalcoholic Fatty Liver Disease in Children and Adolescents Taking Atypical Antipsychotic Medications: Protocol for a Systematic Review and Meta-analysis
Authors: Hatem Reem , Nawaz Faisal A , Al-Sharif Ghadah A , Almoosa Mohammad , Kattan Wid , Tzivinikos Christos , Amirali E Lila , Albanna Ammar
Published: November 2021

Background

Atypical antipsychotics (AAP) are commonly prescribed to children and adolescents and are associated with important adverse effects including weight gain and metabolic syndrome. Nonalcoholic fatty liver disease (NAFLD) is not only the most common pediatric liver disease but is also associated with serious complications including liver cirrhosis.

Objective

Given that NAFLD and AAP are associated with metabolic syndrome, we aim to comprehensively examine the association between AAP and NAFLD in children and adolescents.

Methods

We will conduct a systematic review of studies exploring NAFLD in subjects younger than 18 years on AAP published in English between 1950 and 2020 following the PRISMA (Preferred Reporting items for Systematic Reviews and Meta-Analysis) guidelines.

Results

A PRISMA flowchart will be used present the study results after comprehensively reviewing studies on NAFLD in children and adolescents taking AAP. The first and second systematic searches will be conducted during December 2021. The results are expected to be published in June 2022.

Conclusions

This research project will serve as a foundation for future studies and assist in devising interventions and reforming clinical guidelines for using AAP to ensure improved patient safety.

International Registered Report Identifier (IRRID)

PRR1-10.2196/20168
Validity and Reliability of the Korean Version of the Health Information Technology Usability Evaluation Scale: Psychometric Evaluation
Authors: Lee Jisan , Schnall Rebecca
Published: November 2021

Background

Rigorous development of mobile technologies requires the use of validated instruments to evaluate the usability of these tools, which has become more relevant with the expansion of these technologies. Although various usability evaluation tools have been developed, there are relatively few simple evaluation instruments that have been validated across diseases and languages in mobile health (mHealth) information technology for use in multiple diseases.

Objective

The purpose of this study is to validate the Korean version of the Health Information Technology Usability Evaluation Scale (Korean Health-ITUES) and assess its applicability for different health conditions.

Methods

To develop the Korean Health-ITUES, we used a validation process involving the following 3 steps: (1) customization of the Health-ITUES for menstrual symptoms, (2) translation of the Health-ITUES from English into Korean, and (3) examination of the reliability and validity of the instrument. The translation process adhered to the World Health Organization (WHO) guidelines for translation and back-translation, expert review, and reconciliation.

Results

The Korean Health-ITUES showed reliable internal consistency with Cronbach α=.951; meanwhile, factor loadings of the 20 items in the 4 subscales ranged from 0.416 to 0.892.

Conclusions

The Health-ITUES demonstrated reliability and validity for its use in assessing mHealth apps’ usability in young Korean women with menstrual discomfort. Given the strong psychometric properties of this tool in Korean and English and across 2 different health conditions, the Health-ITUES is a valid and reliable instrument for assessing the usability of mHealth apps. The Health-ITUES is also a valid instrument for evaluating mHealth technologies, which are widely used by patients to self-manage their health and by providers to improve health care delivery.
Enamel Renal Syndrome: Protocol for a Scoping Review
Authors: Roomaney Imaan A , Kabbashi Salma , Chetty Manogari
Published: November 2021

Background

Enamel renal syndrome (ERS) (OMIM 204690) is a rare autosomal recessive disorder characterized by hypoplastic amelogenesis imperfecta, failed tooth eruption, intrapulpal calcifications, gingival enlargement, and nephrocalcinosis. The rarity of the condition and the variability of the phenotype has led to ERS not being fully characterized.

Objective

This scoping review aims to account for the range and current state of knowledge on ERS and synthesize these findings into a comprehensive summary, focusing on the pathophysiology, genotype-phenotype correlations, and patient management from a dental perspective.

Methods

The authors will conduct a systematic search of PubMed (MEDLINE), BioMed Central, EbscoHost Web, Web of Science, and WorldCat. We will include all studies with human participants with a confirmed diagnosis of ERS. Articles will be screened in two stages (ie, initially by title and abstract screening and then full-text screening by two independent reviewers). Data extraction will be conducted using a customized electronic data extraction form. We will provide a narrative synthesis of the findings from the included studies. We will structure the results according to themes.

Results

This protocol is registered with the Open Science Framework. The electronic search was conducted in July 2020 and updated in April 2021. The research findings will be published in an open access journal.

Conclusions

Dentists should be able to identify patients with clinical features of ERS so that they receive appropriate referrals for renal evaluation, genetic counseling, and oral rehabilitation to increase the patient’s quality of life. A scoping review is the most appropriate method to conduct this comprehensive exploration of the current evidence, which may be sparse due to the rarity of the condition. It will also enable us to identify gaps in the research.

Trial Registration

Open Science Framework; https://osf.io/cghsa

International Registered Report Identifier (IRRID)

DERR1-10.2196/29702
Trends in Remote Health Care Consumption in Sweden: Comparison Before and During the First Wave of the COVID-19 Pandemic
Authors: Milos Nymberg Veronica , Ellegård Lina Maria , Kjellsson Gustav , Wolff Moa , Borgström Bolmsjö Beata , Wallman Thorne , Calling Susanna
Published: November 2021

Background

Remote assessment of respiratory tract infections (RTIs) has been a controversial topic during the fast development of private telemedicine providers in Swedish primary health care. The possibility to unburden the traditional care has been put against a questionable quality of care as well as risks of increased utilization and costs. The COVID-19 pandemic has contributed to a changed management of patient care to decrease viral spread, with an expected shift in contact types from in-person to remote ones.

Objective

The main aim of this study was to compare health care consumption and type of contacts (in-person or remote) for RTIs before and during the COVID-19 pandemic. The second aim was to study whether the number of follow-up contacts after an index contact for RTIs changed during the study period, and whether the number of follow-up contacts differed if the index contact was in-person or remote. A third aim was to study whether the pattern of follow-up contacts differed depending on whether the index contact was with a traditional or a private telemedicine provider.

Methods

The study design was an observational retrospective analysis with a description of all index contacts and follow-up contacts with physicians in primary care and emergency rooms in a Swedish region (Skåne) for RTIs including patients of all ages and comparison for the same periods in 2018, 2019, and 2020.

Results

Compared with 2018 and 2019, there were fewer index contacts for RTIs per 1000 inhabitants in 2020. By contrast, the number of follow-up contacts, both per 1000 inhabitants and per index contact, was higher in 2020. The composition of both index and follow-up contacts changed as the share of remote contacts, in particular for traditional care providers, increased.

Conclusions

During the COVID-19 pandemic in 2020, fewer index contacts for RTIs but more follow-up contacts were conducted, compared with 2018-2019. The share of both index and follow-up contacts that were conducted remotely increased. Further studies are needed to study the reasons behind the increase in remote contacts, and if it will last after the pandemic, and more clinical guidelines for remote assessments of RTI are warranted.
Relationship Between Illness Representations and Symptoms of Internet Gaming Disorder Among Young People: Cross-Lagged Model (Preprint)
Authors: Yang Xue , Wong Kei Man , She Rui , Zhao Chengjia , Ding Nani , Xu Huihui , Tu Xiaolian , Lai Xinyi , Zhang Guohua
Published: November 2021

BACKGROUND

The common-sense model of illness suggests that mental representations of health threats may affect one’s behavioral reactions to them and health status. Internet gaming disorder is a newly defined mental disorder. Illness representations of internet gaming disorder may affect one’s risk of internet gaming disorder. In turn, symptoms of internet gaming disorder may affect one’s perceptions of the disorder.

OBJECTIVE

This study aimed to investigate the relationships between illness representations and symptoms of internet gaming disorder in college students.

METHODS

A 1-year longitudinal study was conducted with a convenience sample of Chinese college students (n=591; 342/591, 57.9% female).

RESULTS

Of the participants, 10.1% (60/591) and 9.1% (54/591) were classified as having probable internet gaming disorder at baseline (T1) and follow-up (T2), respectively. The correlations between some dimensions of illness representations regarding internet gaming disorder (ie, consequence, timeline, personal control, treatment control, and concern) at T1 and symptoms of internet gaming disorder at T2 and between symptoms of internet gaming disorder at T1 and the dimensions of illness representations at T2 (ie, consequence, timeline, personal control, and emotional response) were statistically significant. The cross-lagged model fit the data well ((χ2/df=2.28, comparative fit index=.95, root mean square error of approximation=.06) and showed that internet gaming disorder at T1 was positively associated with unfavorable illness representations at T2.

CONCLUSIONS

Individuals with more severe symptoms of internet gaming disorder had more pessimistic perceptions about the disorder. Such cognitive perceptions may affect one’s emotional and behavioral reactions towards the disorder (eg, greater levels of depression and low self-control intention) and should be modified by educational programs and psychological interventions.
Preferences for Using a Mobile App in Sickle Cell Disease Self-management: Descriptive Qualitative Study (Preprint)
Authors: Mayo-Gamble Tilicia L , Quasie-Woode Delores , Cunningham-Erves Jennifer , Rollins Margo , Schlundt David , Bonnet Kemberlee , Murry Velma McBride
Published: November 2021

BACKGROUND

Individuals with sickle cell disease (SCD) and their caregivers may benefit from technology-based resources to improve disease self-management.

OBJECTIVE

This study explores the preferences regarding a mobile health (mHealth) app to facilitate self-management in adults with SCD and their caregivers living in urban and rural communities.

METHODS

Five community listening sessions were conducted in 2 urban and rural communities among adults with SCD and their caregivers (N=43). Each session comprised 4 to 15 participants. Participants were asked questions on methods of finding information about SCD self-care, satisfaction with current methods for finding SCD management information, support for SCD management, important features for development of an mHealth app, and areas of benefit for using an mHealth app for SCD self-management. An inductive-deductive content analysis approach was implemented to identify the critical themes.

RESULTS

Seven critical themes emerged, including the current methods for receiving self-management information, desired information, recommendations for communicating sickle cell self-management information, challenges of disease management, types of support received for disease management, barriers to and facilitators of using an mHealth app, and feature preferences for an mHealth app. In addition, we found that the participants were receptive to using mHealth apps in SCD self-management.

CONCLUSIONS

This study expands our knowledge on the use of mHealth technology to reduce information access barriers pertaining to SCD. The findings can be used to develop a patient-centered, user-friendly mHealth app to facilitate disease self-management, thus increasing access to resources for families of patients with SCD residing in rural communities.
Peer Review of “Medical Brain Drain From Southeastern Europe: Using Digital Demography to Forecast Health Worker Emigration” (Preprint)
Authors: Komušanac Monika
Published: November 2021

UNSTRUCTURED

This is a peer review report for ms#30831.
Promoting Health Behavior Change in the Preconception Period: Combined Approach to Intervention Planning (Preprint)
Authors: Scott Jodie , Oxlad Melissa , Dodd Jodie , Szabo Claudia , Deussen Andrea , Turnbull Deborah
Published: November 2021

BACKGROUND

Half of women begin pregnancy above the healthy weight range, increasing the risk of complications and adversely affecting the lifelong health of their babies. Maternal obesity remains the strongest risk factor for offspring obesity across childhood, adolescence, and adulthood. Previous research suggests that women should be encouraged to be within a healthy weight range before conception to improve health outcomes.

OBJECTIVE

We outlined the intervention planning and design process to develop an evidence-informed eHealth intervention to promote weight management. The intervention, based on psychological theories and behavior change techniques, has been developed for women affected by overweight or obesity who intend to become pregnant. The Begin Better web application is part of an integrated program being evaluated in a clinical trial to assess if weight management before pregnancy can influence clinical outcomes for mothers and babies.

METHODS

Our intervention development process was guided by intervention mapping and person-based methods. This study documents steps 2 to 4 of a 6-step iterative intervention mapping approach informed by the Information-Motivation-Behavioral Skills model and the findings of a previous interview study. We defined behavior change objectives for each of the Information-Motivation-Behavioral Skills behavioral determinants as well as theory-based behavior change techniques and practical strategies. We also used persuasive system design principles to assist in translating these strategies into a digital environment.

RESULTS

The resultant intervention comprises nutritional and physical activity content along with psychological strategies, which are notably absent from mainstream weight management programs. Strategies to increase motivation, garner social support, and promote self-care are integral to maintaining engagement with the intervention, which aims to improve lifestyle behaviors and enhance well-being. Important elements include tracking mechanisms for percentage progress toward goals to enable feedback on behaviors and outcomes; in-application messages of praise on entry of goals or habits; and strategies to prompt habit formation and action planning via small, easily achievable steps toward positive change.

CONCLUSIONS

Design decisions and processes for idea generation about intervention content, format, and delivery are often not reported. In this study, we respond to this gap in the literature and outline a process that is potentially transferable to the development of other interventions.
Spatiotemporal distribution of HIV self-test kits purchased online and implications for HIV prevention: analysis of transaction data from a leading e-commerce platform in China (Preprint)
Authors: Luo Ganfeng , Su Lingyun , Feng Anping , Lin Yi-Fan , Zhou Yiguo , Yuan Tanwei , Hu Yuqing , Fan Song , Lu Yong , Lai Yingsi , Shi Qian , Li Jun , Han Mengjie , Zou Huachun
Published: November 2021

BACKGROUND

HIV self-testing (HIVST) holds great promise for expanding HIV testing. Yet, large scale data on HIVST behavior is scant. Millions of HIVST kits were sold through e-commerce platforms each year.

OBJECTIVE

This study aimed to analyze spatiotemporal distribution of the HIVST kit purchasing population (HIVSTKPP) in China.

METHODS

Deidentified transaction data were retrieved from a leading e-commerce platform in China. Bayesian spatiotemporal analysis was performed to locate hot spots with HIVSTKPP rates. Spatial autocorrelation analysis and space-time cluster analysis were conducted to identify clusters of HIVSTKPP

RESULTS

Between 1 January 2016 and 31 December 2019, a total of 2.18 million anonyms in China placed 4.15 million orders and purchased 4.51 million HIVST kits online. In each year, the observed monthly HIVSTKPP peaked in December, the month of the World AIDS Day. HIVSTKPP rates per 100,000 population significantly increased from 20.62 in 2016 to 64.82 in 2019. Hot spots were mainly located in municipalities, provincial capitals, and large cities, while high-high clusters and high-demand clusters were predominantly detected in cities along the southeast coast. We found positive correlations between a region’s number of HIV testing facilities, urbanization ratio, and GDP per capita and the HIVSTKPP.

CONCLUSIONS

Our study identified key areas in larger demands for HIVST for public health policymakers to re-allocate resources and optimize the HIV care continuum. Further research combining spatiotemporal patterns of HIVST with HIV surveillance data is urgently needed to identify potential gaps in current HIV-monitoring practices.
COVID-19 Mental Health Stressors of Health Care Providers in the Pandemic Acceptance and Commitment to Empowerment Response (PACER) Intervention: Qualitative Study (Preprint)
Authors: Sato Christa , Adumattah Anita , Abulencia Maria Krisel , Garcellano Peter Dennis , Li Alan Tai-Wai , Fung Kenneth , Poon Maurice Kwong-Lai , Vahabi Mandana , Wong Josephine Pui-Hing
Published: November 2021

BACKGROUND

Since the pandemic, more Canadians have reported poorer mental health. A vital group experiencing a high level of stressors consists of health care providers (HCPs) caring for COVID-19 patients, carrying out public health responses, or working with vulnerable populations. The mental health of HCPs is negatively affected by the pandemic, not only at work but also at home and in the community. Intersecting stressors at multiple levels contribute to HCPs’ experiences of fatigue, insomnia, anxiety, depression, and posttraumatic stress symptoms.

OBJECTIVE

The aim of this qualitative study was to explore the pandemic stressors experienced by HCPs at work, at home, and in the community before participating in the Pandemic Acceptance and Commitment to Empowerment Response (PACER) online intervention.

METHODS

Informed by a social ecological approach, we used a qualitative reflective approach to engage 74 HCPs in diverse roles. Data were collected during the first 2 waves of the COVID-19 pandemic (June 2020 to February 2021) in Canada.

RESULTS

Informed by a social ecological framework, 5 overarching themes were identified in our thematic analysis: (1) personal level stressors that highlight HCPs’ identities and responsibilities beyond the workplace; (2) interpersonal level stressors from disrupted social relationships; (3) organizational stressors that contributed to unsettled workplaces and moral distress; (4) community and societal stressors attributed to vicarious trauma and emotional labor; and (5) the multilevel and cumulative impacts of COVID-19 stressors on HCPs’ health.

CONCLUSIONS

COVID-19 is not merely a communicable disease but also a social and political phenomenon that intensifies the effects of social inequities. Current understanding of pandemic stressors affecting HCPs is largely partial in nature. Although workplace stressors of HCPs are real and intense, they need to be explored and understood in the context of stressors that exist in other domains of HCPs’ lives such as family and community to ensure these experiences are not being silenced by the “hero” discourses or overshadowed by professional demands.
Penerapan Antarmuka Adaptif Berbasis Perilaku Pemain pada E-Learning Bidang Pemrograman
Authors: Fajar Pradana  , Fitra A. Bachtiar  , Retno Indah Rokhmawati
Published: November 2021

Pada masa pandemi seperti sekarang ini, bidang pendidikan mengalami dampak yang signifikan dalam pelaksanaannya. Proses belajar mengajar yang sebelumnya dilakukan secara tatap muka, saat ini harus dilaksanakan secara daring. Pembelajaran daring dengan memanfaatkan e-learning sangat bermanfaat bagi pembelajar karena dapat diakses secara daring kapan pun dan dari mana pun. E-learning diharapkan tidak hanya menjadi tempat berbagi file materi sebagai pendukung pembelajaran, tetapi perannya dituntut dapat menggantikan peran guru atau dosen di kelas. Dalam proses belajar mengajar, kondisi dan perilaku siswa merupakan hal yang penting diketahui. Pengetahuan tentang kondisi dan keadaan siswa ketika belajar dapat digunakan oleh pengajar sebagai bahan untuk meningkatkan kualitas maupun proses pembelajaran bagi siswa. Kebanyakan e-learning yang ada sekarang belum dilengkapi dengan fitur untuk mendeteksi keadaan siswa selama menggunakan sistem. Pada makalah ini dilakukan penerapan antarmuka yang adaptif sebagai cerminan e-learning yang mampu menyesuaikan dengan karakteristik perilaku pengguna. Pengujian kinerja menunjukkan hasil bahwa dengan jumlah data log mencapai 950 pengguna aktif, dibutuhkan waktu 23,35 ms. Sementara itu, pada uji fungsionalitas, sistem berhasil menampilkan antarmuka sesuai dengan cluster member.
Configuración por el Tribunal Constitucional Español del Derecho a la legalidad sancionadora en el ámbito de las sanciones administrativas
Authors: Montero Cartes Cristian Ismael
Published: November 2021

El objetivo del presente texto es exponer sucintamente algunas de las principales líneas jurisprudenciales del TC español acerca del derecho fundamental a la (o principio de) legalidad penal -consagrado en el artículo 25.1 de la Constitución Española de 1978 (CE)-, señaladamente, su aplicación al Derecho administrativo sancionador a través de la afirmación de la teoría del ius puniendi único del Estado.