bluuebunny/crossref_metadata_2025 huggingface dataset:
Potential methods to reduce the thermal impact of vitrified waste from spent mixed oxide fuel on geological repositories
Authors: Hamada Ryo , Sakuragi Tomofumi , Asano Hidekazu , Oniki Toshiro , Uchiyama Midori
Published: February 2023

Compared to the vitrified, high-level radioactive waste (HLW) from spent UO2 fuel (UO2-HLW glass), that of mixed oxide (MOX) fuel (MOX-HLW glass) exhibits high heat generation over a long period of time. Thus, to reduce the associated waste volume and repository footprint, it is essential to prevent bentonite buffer alteration by mitigating heat generation. In this study, we evaluated five potential methods of decreasing the bentonite buffer temperature in a geological repository for MOX-HLW glass. Of these five methods, the separation of minor actinides (MA) from high-level liquid waste (HLLW) was the most effective. This is because the main nuclide involved in heat generation in MOX-HLW glass is Am-241. An MA separation rate of 81% was required to maintain the bentonite buffer temperature below the Japanese upper disposal limit of 100 °C. Thus, it is important to measure the amount of Am-241 when disposing of MOX-HLW glass. Assuming that only Am-241 was disposed of, the maximum Am-241 waste loading under a bentonite buffer temperature of 100 °C was 0.33 wt%, equating to the disposal of only 1.32 kg of Am-241 per 400 kg of MOX-HLW glass. Thus, there is a need for new methods of treating and disposing of Am-241.

Graphical abstract

Relationship between bentonite buffer temperature and (a) minor actinide (MA) separation ratio from high-level liquid waste (HLLW), (b) mixed oxide (MOX) high-level radioactive waste (HLW) glass and UO2 HLLW mixing ratio, (c) waste loading in MOX-HLW glass, (d) MOX-HLW glass storage time, and (e) canister footprint, representing five methods of mitigating heat generation from disposed MOX-HLW glass.
UMA NOVA-VELHA HISTÓRIA DAS IDEIAS: “PENSAMENTO EDUCACIONAL” NO 1 CONGRESSO BRASILEIRO DE HISTÓRIA DA EDUCAÇÃO (2000)
Authors: Bontempi Jr Bruno
Published: February 2023

Analisa as comunicações sobre “Pensamento Educacional” no 1o Congresso Brasileiro de História da Educação (Rio de Janeiro, 2000). Neste artigo, relacionam-se os seus conteúdos a informações históricas sobre as práticas de pesquisa na pós-graduação e as heranças disciplinares. Considera-se que as reuniões científicas revelam conteúdos, cânones e modos de fazer de uma comunidade intelectual, assim como as posições e relações interpessoais e institucionais implicadas na produção do conhecimento. Conclui-se que as comunicações refletem a expansão regional das instituições, a nucleação de linhas e grupos de pesquisa, o predomínio das instituições públicas e do fomento governamental. Além disso, a tradição da história da pedagogia prepondera no tratamento da temática, por ter sido replicada em orientações e incorporada como um saber-fazer acadêmico.
EXPERIMENTAL INVESTIGATION OF FLOW BOILING PARAMETERS IN A TRANSVERSE GROOVED HORIZONTAL TUBE: CRITICAL HEAT FLUX, PRESSURE DROP, AND HEAT TRANSFER COEFFICIENT
Authors: Tank P. N. , Sridharan Arunkumar , Prabhu S. V.
Published: February 2023

An experimental investigation was conducted to examine critical heat flux (CHF), boiling pressure drop, and local heat transfer coefficient in a horizontal channel with transverse grooves for flow boiling with R-123. Measurement of the wall temperature of the channel was done using a thermal camera. Five test sections were used for the study. A combination of groove pitch (p) of 18.6 and 11 mm and groove height (e) of 1 mm and 0.55 mm were used for the study. The groove pitch-to-height (p/e) ratios used were 11, 20, 18.6, and 33.8. Experiments were carried out for different heat fluxes in the range from 180 to 1259 kW/m2, six different mass fluxes from 180 to 1259 kg/m2s, and Reynolds numbers from 5834 to 51770. In the grooved channel compared with the smooth tube, an improvement in heat transfer and CHF with the higher pressure drop was found. The boiling heat transfer coefficient increases with a decrease in (p/e) ratio. The enhancement of heat transfer coefficient and CHF improves with a decrease in (p/e) ratio. The maximum enhancement of CHF for (p/e) ratios of 11, 18.6, 20, and 33.8 is found to be 134%, 87%, 57%, and 53%, respectively. An abrupt increase in test channel wall temperature is an indication of CHF occurring. CHF was observed at the top portion of the grooved channel and was found to be of departure from nucleate boiling type.
BİTCOİN İLE GELİŞMİŞ VE GELİŞMEKTE OLAN ÜLKELER ARASINDAKİ VOLATİLİTE YAYILIM ETKİSİNİN TVP-VAR İLE ANALİZİ
Authors: GÖKGÖZ Halilibrahim , KAYAHAN Cantürk
Published: February 2023

Bu çalışmada, Bitcoin ile gelişmiş ve gelişmekte olan ülkelerin hisse senedi piyasaları arasındaki volatilite yayılım ilişkisinin incelenmesi ve bulguların finansal piyasaları etkileyen küresel olaylar bağlamında değerlendirilmesi amaçlanmıştır. Bu amaçla 03.01.2017-25.03.2022 dönemi, Bitcoin, MSCI ABD, MSCI Avrupa ve MSCI gelişmekte olan piyasalar endeksi günlük verilerine zamanla değişen parametre vektör otoregresif (TVP-VAR) modeli uygulanmıştır. Uygulama sonucunda Bitcoin’in MSCI ABD ve MSC Avrupa karşsısında net volatilite alıcısı olduğu ve MSCI gelişmekte olan piyasalar karşısında net volatilite yayıcısı olduğu gözlenmiştir. MSCI ABD’nin net volatililite yayıcısı ve MSCI gelişmekte olan piyasaların ise net volatilite alıcısı olduğu tespit edilmiştir. Ayrıca Bitcoin’in gelişmiş ve gelişmekte olan piyasalarla zayıf bağlantılı olduğu gözlenmiştir. Bulgular, volatilite yayılımının aşırı artış-azalış gösterdiği dönemlerde tüm dünyayı etkileyen küresel olaylar olduğunu göstermiştir.
Des prénoms joola aux prénoms des Blancs
Authors: DIEDHIOU Paul , BADJI Abdou , DIATTA Jean Bernard
Published: February 2023

Le prénom occupe une place de choix dans la constitution de la personne puisqu’il est en quelque sorte le premier marqueur identitaire qui place l’homme dans le groupe. Aujourd’hui il est devenu un objet d’étude investigué par les ethnologues, les linguistes, les littéraires qui ne mettent pas l’accent sur l’auto-nomination. C’est dans cette perspective que s’inscrit cet article dont l’objet est d’esquisser une anthropologie de la mort par le prénom en mettant au cœur de l’analyse le passage de prénoms joola aux prénoms des Blancs. Ce passage est un indicateur nous permettant d’appréhender les mutations en cours en Basse Casamance. Celles-ci nous ont amenés à faire un examen critique du concept du dialogue islamo-chrétien.
Altmış Beş Yaş ve Üzeri Erişkinlerde Pnömokok Bağışıklaması ve Ülkemizdeki Pnömokok Aşı Uygulamaları: Derleme
Authors: ÖZARSLAN Fatma , BARAN AKSAKAL F. Nur
Published: February 2023

Sorunu ortaya çıkmadan önlemek şüphesiz tedaviye göre kolay ve ucuz bir yöntemdir. Birinci basamak sağlık hizmetlerinin esasını oluşturan koruyucu
sağlık hizmetlerinden aşılama, aşı ile önlenebilir hastalıkların önlenmesi ve bu hastalıklara bağlı kayıpların azaltılabilmesi için olmazsa olmazdır. Yaşlılarda
ve yüksek riskli erişkinlerde önemli morbidite ve mortaliteye sebep olan pnömokok enfeksiyonlarına karşı ülkemizde uygulanan iki tip aşı vardır: konjuge
pnömokok aşısı ve polisakkarid pnömokok aşısı. Erişkinlerde pnömokok aşılarının yararı kanıtlanmış olmasına rağmen aşı uygulanma oranları hedeflenen
düzeyde olmadığı için iyileştirme çalışmalarına ihtiyaç vardır. Birinci basamak çalışanları başta olmak üzere aşı uygulayıcılarının eğitilmesi ve farkındalığı-
nın artırılması, topluma aşıların yararları ve olası riskleri hakkında yeterli bilgi verilmesi, sağlık kontrollerinin ve kayıtların düzenli olması, aşıların yeterli
miktarda ve ücretsiz olarak sağlanması gerekmektedir.
Bu derleme erişkinlerde pnömokok aşı uygulamalarında mevcut durumu gözden geçirmek ve aşılama oranlarını arttırmak için yapılması gereken uygula-
maları vurgulamak amacıyla yazılmıştır.
Kültürel Miras Farkındalık Ölçeği: Geçerlik ve Güvenirlik Çalışması
Authors: DEMİR Yılmaz
Published: February 2023

Bu araştırmada ortaokul öğrencilerinin kültürel mirasa yönelik farkındalıklarını belirleyebilmek için bir veri toplama aracı geliştirmek amaçlanmıştır. Bu doğrultuda ilk olarak madde havuzu oluşturulmuştur. Oluşturulan 69 maddelik deneme formunda uzmanlardan alınan dönütlere göre düzeltmeler yapılmış ve madde sayısı 48’e indirilmiştir. Ardından 48 maddelik aday form deneme uygulaması olarak 106 ortaokul öğrencisiyle “Sesli Düşünme Yöntemi” kullanılarak seviye ve anlaşılırlık bakımından uygunluğu test edilmiştir. Öğrencilerle yapılan bu çalışmadan sonra 10 madde için tekrar uzman görüşüne başvurularak bu maddelerin çıkarılmasına karar verilmiş, düzeltilmesi önerilen maddelerde ise gerekli değişiklikler yapılmış ve 38 maddelik deneysel form hazır hale getirilmiştir. 38 maddelik ölçeğin taslağı açımlayıcı faktör analizi (AFA) için farklı kademelerdeki 450 ortaokul öğrencisine uygulanmıştır. AFA sonucunda deneysel formun üç faktörlü (X2= 973,619; sd= 592; p<,05; X2/sd= 1,6; RMSEA= ,03; CFI= ,95; TLI= ,94 ve SRMR= ,05) modele uygun olduğu belirlenmiştir. Ölçeğin yapısının doğrulanıp doğrulanmadığı test etmek için 294 ortaokul öğrencisiyle doğrulayıcı faktör analizi (DFA) yapılmıştır. Uygulanan ölçekten elde edilen verilerin analiz sonuçlarının uyumlu olduğu ve önerilen modelin kabul edilebilir (X2= 914,731; sd= 591; p<,05; X2/sd= 1,54; RMSEA=,04; CFI=,92; TLI=,92 ve WRMR=1,1) olduğu sonucuna ulaşılmıştır. Ölçeğin Cronbach Alfa değeri ,87 olarak belirlenmiştir. Ulaşılan sonuçlar KMFÖ’nün güvenilir ve geçerli ölçme aracı olduğunu ortaya koymaktadır.
Evaluation of Bond Strength between Ultra-High-Performance Concrete and Normal Strength Concrete: An Overview
Authors:   School of Civil Engineering, Tianjin University, Tianjin 300350, China, Bibi Farouk Abdulwarith Ibrahim , Haruna S.I. ,   School of Civil Engineering, Tianjin University, Tianjin 300350, China
Published: February 2023

Ultra-high-performance concrete (UHPC) is an advanced, durable cementitious material with excellent mechanical properties, which makes it an appropriate material for strengthening, repair, and retrofitting of damaged concrete structures. The UHPC as a repair material on normal strength concrete (NSC) depends on the quality of the bond strength at the interface. The interface behavior of UHPC-NSC concrete has a significant impact on its overall durability performance. This paper reviews the studies conducted on the bond strength at the concrete interface to determine the effectiveness of different bond strength testing techniques. The review has shown that the bond strength is commonly evaluated through splitting tensile, slant shear, direct shear, pull-off, bi-surface shear, and third-point flexural tests. Slant shear and splitting tensile test methods are the most common techniques used to evaluate the performance of bond strength between UHPC and NSC. splitting tensile tests, stress is directly applied at the concrete interface, while in the slant shear test, the interface surface is subjected to combined compressive stress and shear stress. Thus, Splitting tensile tests produces more accurate results than the slant shear test. Bi-surface shear and third-point flexural tests are easy to conduct and give a result similar to splitting and direct shear tests. However, further investigations are required on the reliability of the test methods under different conditions. In terms of failure modes, splitting tensile tests produces a more consistent result compared to the pull-off test.
Effect of Different Condition on Voltage Generation and Thermal Gradient from Road Pavement Using Thermoelectric Generator
Authors:   Faculty of Electronics and Computer Engineering, Universiti Teknikal Malaysia Melaka, Malaysia, Sharuddin Muhammad Syadza , Md. Yusop Azdiana ,   Faculty of Electronics and Computer Engineering, Universiti Teknikal Malaysia Melaka, Malaysia., Mohd Isira Ahmad Sadhiqin ,   Faculty of Electronics and Computer Engineering, Universiti Teknikal Malaysia Melaka, Malaysia, Khamil Khairun Nisa ,   Faculty of Electronics and Computer Engineering, Universiti Teknikal Malaysia Melaka, Malaysia
Published: February 2023

Thermal energy harvesting is an interesting topic to be studied due to its advantage of being easily to be acquired, whether from natural sources or from waste heat. Road pavement is one of the example of waste heat sources which can be easily harvested because asphalt road is paved everywhere to facilitate land transportation. The thermal energy from a road can be collected by using a thermoelectric generator (TEG). TEG operates based on the Seebeck effect; when there are temperature differences between two dissimilar electrical conductors, potential differences will be generated. Harvesting thermal energy from the road using TEG does not only provide a clean, renewable source of energy but also can save cost. The government does not have to build electricity poles along the road to power up road lamps and traffic light, which can cost a fortune, especially in rural areas. This research aims to investigate factors that can affect thermoelectric generator energy harvesting from asphalt road, which includes, TEG configuration, TEG cooling technique, and thermal conductivity. Pavement samples were built with aluminium and copper plates installed to collect thermal energy and were tested with different conditions. The final result shows that thermoelectrics with 4x1 configuration provides the highest voltage output with 142.7 mV. The TEG cooling technique using a water tank generates the highest output voltage with 281 mV. Copper plate, which has higher thermal conductivity than aluminium generates more output voltage with 36.9 mV of voltage differences between them.
Evaluation of Most Influential Factors Affecting Road Traffic Accidents in Sidon, Lebanon
Authors:   Civil Engineering Department, Faculty of Civil and Environmental Engineering, Near East University, North Cyprus, Turkey, Karim Faisal , Albrka Ali Shaban Ismael ,   Civil Engineering Department, Faculty of Civil and Environmental Engineering, Near East University, North Cyprus, Turkey
Published: February 2023

Enlargement of the transportation industry in developing countries has had a tremendous impact on the advancement of those countries. This advancement has had both positive and negative impacts on society. Drawbacks primarily include the emission of harmful gases from vehicles, traffic overcrowding, and most importantly, injuries, and deaths by traffic accidents, which have increased significantly. This paper focuses on and investigates the human, vehicle and environmental factors affecting road traffic accidents in Lebanon in order to increase the knowledge surrounding how the elements have impacted the increase in accidents in Lebanon. A quantitative method (questionnaire) was used to collect data to understand the behavior of road users, while the relative importance index (RII) was used to analyze the data. The results illustrate that the top three vehicle-related factors that lead to an increase in the accidents in Lebanon according to the respondents are steering wheel defects with an RII of 3.807, mechanical faults with an RII of 3.489 and 2.934 for lack of vehicles among all the groups. Furthermore, the human factors were recognized to have a slight impact on road traffic accidents with the highest RII of 1.719 for failure to follow driving codes. In conclusion, a country’s development not only depends on economic measure, but it is also determined based on how effective the traffic system infrastructure is and the steps taken to minimize injuries.
Geospatial Information System Based on Indoor Plan UKM (FKAB)
Authors:   Dept. of Mechanical & Manufacturing Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Malaysia, Bin Ishak Zikrul Hakiem , Mohamed Haris Sallehuddin ,   Dept. of Mechanical & Manufacturing Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Malaysia, Long Wang ,   School of Mechanical Engineering Hangzhou Dianzi University, China
Published: February 2023

In recent years, the academic field has seen tremendous leaps in mapping and navigation technology. Features such as accuracy, functionality, time efficiency and ease of access in mobile mapping applications have poured into the market, which has led to the near extinction of conventional paper maps. Big players such as Google Maps, MapBox, Bing Maps, OpenStreetMap and many others are enabling Geospatial Information Systems (GIS) to be accessed with ease. However, the problem arises as GIS is more tailored towards outdoor mapping and navigation information through the implementation and utilization of Global Positioning System (GPS) coordinates. The main objective of this study was to enable GIS incooperated together with georeferenced image containing global positioning coordinates (GPS) making it feasible and compatible for the purpose of positioning and navigation focusing in an indoor environment. In this research, we present a method for utilising GIS for indoor localisation focusing on using Quantum GIS (QGIS) as the open source Geospatial Data Abstraction Library (GDAL), and the rendering of raster maps by locating ground control points (GCP). As a case study, the method was implemented on the 2nd Floor, East Wing of the Faculty of Engineering and Built Environment (FKAB) of Universiti Kebangsaan Malaysia (UKM), as the indoor space of interest. The significant findings of this paper contribute to the possibility of using GPS coordinates in an indoor environment for accurate positioning. Consequently, the proposed method has the potential to perform as an easily implementable localisation technique in Simultaneous Localisation and Mapping (SLAM) applications for mobile robots.
La segregación escolar y su impacto en el rendimiento académico del alumnado de educación primaria en España.
Authors: Cabrera Leopoldo , Bianchi Daniel
Published: February 2023

Este artículo estudia los efectos de la desigualdad social en la escolarización diferencial del alumnado en la enseñanza primaria por centros y su repercusión en los desiguales resultados académicos en pruebas externas de evaluación. La realidad actual, y el pasado, muestran efectos negativos para el rendimiento académico del alumnado desfavorecido socioeconómica y culturalmente, escolarizado en mayor proporción en centros segregados por composición social. La democratización de la educación con la escolarización completa en la enseñanza primaria en España, desde hace décadas, no ha resuelto la aleatoriedad de los resultados académicos del alumnado que cabría esperar en procesos de escolarización con igualdad de oportunidades. La variable composición social de las escuelas, creada con el índice socioeconómico y cultural familiar del alumnado, muestra efectos significativos en el rendimiento de matemáticas del alumnado de primaria, si bien los centros de igual composición social muestran variabilidad significativa entre ellos, lo que asegura que las escuelas cuentan con capacidad para cambiar los resultados académicos, independientemente de su caracterización por composición de su alumnado. Los datos proceden del Informe TIMSS 2019, publicado por la IEA en diciembre de 2020.
Аnatoly D. Klimiashvili
Authors: Polunina Natalia V. , Alexandrov Oleg V. , Sviridov Sergey V.
Published: February 2023

On January 24, 2023, a member of the editorial board of the Russian Medical Journal, Candidate of Medical Sciences, Associate Professor of the Department of Faculty Surgery of the Medical Faculty of the N.I. Pirogov (Moscow, Russia), Anatoly Davidovich Klimiashvili, died.
Unusual symptoms of iron deficiency anemia (2 clinical observations)
Authors: Kalyadin Sergey B. , Kostryukina Lyudmila N. , Terenteva Janna N. , Fedorov Oleg A. , Pahomova Mariya A.
Published: February 2023

Iron deficiency is a leading cause of anemia, the most common malnutrition worldwide, affecting 42% of children worldwide. Most often, iron deficiency occurs in children of the first year of life and adolescents; its prevalence in adolescents has pronounced gender differences. In Russia, it is much more common in girls in 17.231.0% of cases, which is 1.6 times higher than in boys. The presence of delayed adverse effects of iron deficiency at an early age has been established, therefore, timely correction of sideropenic conditions in young children is important for the prevention of long-term consequences of a childs development. The article presents two clinical cases of iron deficiency anemia in adolescent girls who had iron deficiency in the first year of life. On the example of the first clinical observation, we observe the development of alopecia against the background of severe sideropenia as part of the epithelial syndrome with iron deficiency anemia of moderate severity. Iron deficiency in this case is multifactorial maternal anemia during pregnancy, spontaneous subarachnoid hemorrhage, shunt infection, and uncorrected iron deficiency in the first two years. The second clinical example illustrates iron deficiency anemia of mixed genesis in a teenage girl, which was the result of insufficient iron stores at birth, alimentary insufficiency, aggravated against the background of heavy, prolonged menstruation. In this case, there is no hair loss, despite the more severe course of anemia, a long refractory period with iron therapy. The data of clinical cases confirm the significance of low iron stores at birth in the risk of developing iron deficiency anemia in puberty. During the examination of children, the need to take into account the state of the gastrointestinal tract in the algorithm for diagnosing the state of the gastrointestinal tract (detection of malabsorption, blood loss) was shown.
The effect of peptide bioregulators on the resistance of rats to cold-stress factor
Authors: Ganapolsky Vyacheslav P. , Agafonov Pavel V. , Matytsyn Vyacheslav O.
Published: February 2023

BACKGROUND: Biologically active regulatory peptides are the drugs of new type that act selectively on targets, with having no significant side effects.

AIM: The aim of the study was to study the potential effect of peptide preparations Cortexin and Semax on the resistance of the rat organism to the cold stress factor in the model of cold stress maladaptation.

MATERIALS AND METHODS: White outbred male rats were injected intraperitoneally twice daily with placebo (n = 30), Cortexin 5 mg/kg (n = 30) or Semax 0.3 mg/kg (n = 30). Three days after the start of the injection course, the cold-stress effect was simulated in the climate chamber (Feutron, Germany) by cooling the air to 5C at a relative humidity of 7580%.

RESULTS: The use of RP significantly increased the duration of the rectal temperature plateau-period within 35C (moderate hypothermia): in animals of the Cortexin group from 10 days to 12 days, and in animals of the Semax group, from 10 to 14 days. Cortexin demonstrated moderate immunomodulatory properties, and Semax had a more pronounced immunomodulatory effect. Both preparations showed a stress-protective effect. The use of regulatory peptides provided to delay the decrease in the rat general motor activity and exploratory behavior which develops under the influence of a simulated cold-stress factor. A slower rate of decrease in the swimming time of rats under the influence of regulatory peptides was registrated.

CONCLUSIONS: The meteoadaptogenic, stress-protective and nootropic effects of the regulatory peptides Cortexin and Semax were confirmed in rats on the model of cold-stress maladaptation.
The Effects of Trauma Informed Care Training, which Emphasizes Secondary Trauma Education, on New Teachers
Authors:   , McGady Emily M. , Betts Kristen
Published: February 2023

This explanatory sequential study examined and explored the understandings and perceptions a new cohort of K-12 teachers before and after they received Trauma Informed Care (TIC) training, which emphasized the prevention, recognition, and mitigation of secondary trauma (ST). TIC training is a requirement for all teachers. The study aimed at recognizing and managing trauma's ill effects for those who may be impacted by trauma. ST education is focused specifically on supporting caregivers who may indirectly experience trauma as a result of supporting those who have been traumatized. Though TIC is on the rise in the education sector, research indicates that ST education is rarely introduced. Therefore, this study sought to understand the experiences of new teachers as they prepare for the inherent challenges that they may face as caregivers to the 60-80% of US children who may be impacted by trauma. The significance of this study is underscored by the limited research on this subject despite the fact that teachers, as caregivers, are at a higher risk of experiencing ST, which can lead to secondary traumatic stress, depression, decreased job satisfaction, job abandonment and burnout. In order to determine the effectiveness of TIC training, which emphasized ST education as an intervention for new teachers, this mixed methods study analyzed quantitative and qualitative data collected in the form of pre-and post-test surveys and semi-structured interview transcripts. Then the combined data was examined to identify emerging themes. The findings revealed significant positive shifts in perceptions and increased proficiency. The results supported the recommendation that TIC Training, which emphasizes ST education, should be provided to all new teachers to better equip them for the challenges they may face as educators. Keywords: Childhood Trauma, Trauma Informed Care in Education, Secondary Trauma, Compassion Fatigue and Burnout in Educators, Secondary Trauma Education for Teachers
Interdisciplinary Aquatic Program for Children with Disabilities
Authors:   , Paradie Tara , Palisano Robert J
Published: February 2023

Aims: Public School health and wellness programs for children with disabilities are supported by the Individuals with Disabilities Education Act (IDEA, 2004) and Every Student Succeeds Act (ESSA, 2015.) This research describes the lived experiences of paraprofessionals and related service providers/educators in one public school aquatic program regarding promotion of health and wellness, interdisciplinary coordination, service delivery, and student Individualized Education Program outcomes. Methods: 4 paraprofessionals and 5 related service providers/educators from the RSU 16 Aquatic Program participated in an explanatory sequential mixed-methods study consisting of a quantitative survey and two focus groups. Paraprofessionals and related service providers/educators participated in separate focus groups. Analysis of survey data informed questions for the first focus groups. Preliminary analysis of transcripts from the first focus groups informed more in-depth questions for the second focus groups. One researcher conducted thematic analysis of written transcripts from audio recordings to identify qualitative themes, and a second and third researcher reviewed process and analysis. Results: Three themes emerged that were common to both groups: 1) Positive impact on students, 2) Collaboration toward child goals yielded appreciation of one another, 3) Job satisfaction among program staff. Two themes reflected the experiences of paraprofessionals: 1) Knowledge disconnection regarding team member roles and Individualized Education Program goals, and 2) Building trust with children. Two themes reflected the experiences of related service providers/educators: 1) Sense of responsibility for the program, and 2) Uniqueness of aquatic program design. Participants reported that they experienced the program providing healthy, safe, engaging, and challenging activity that was supported by adults which are the 5 tenets of the Whole School, Whole Child, Whole community by the Centers for Disease Control. Participants recommended better communication by service providers/educators on student goals and roles of each team member. Conclusions: The experience of team members suggests the ASU 16 Aquatic Program is an innovative health and wellness program that could be implemented in public schools for children with disabilities.
Extracts of Neptunia prostrata Linn. ameliorates progression of diabetes mellitus and hyperlipidemia in animal models
Authors: Chakraverty Raja , Hossain Chowdhury Mobaswar , Adhikari Anjan , Chakraborty Pranabesh
Published: February 2023

Background: The herb Neptunia prostrata Linn. belonging to the family Mimosaceae has been used in folkloric medicine in the North-eastern states of India of Assam, Tripura and Meghalaya by indigenous herbal healers since time immemorial but there is a scarcity of any background study documenting its use as an antimicrobial herb. For the same, plants were collected and authenticated.
Methods: Following identification of these herbs methanolic, ethanolic, pet ether and chloroform extracts were prepared using soxhlation. Acute toxicity study as per OECD guidelines 420 was assessed in wistar albino rats and in swiss albino mice (n=5) of both sexes at doses of 2000 mg/kg body weight and did not reveal any morbidity or mortality in the animals within the stipulated period. Phytochemical screening was performed on all four extracts of Neptunia prostrata.
Results: Phytochemical constituents depicted presence of glycoside, flavonoids in only ethanolic, methanolic and chloroform extracts. Alkaloids were present in the chloroform extract. The antidiabetic and antihyperlipidemic activity was performed by HFD-STZ models in rats. The herbs showed antioxidant activity comparable to standard antioxidants in-vitro such as Ascorbic acid (Vitamin C) with comparable IC50 values.
Conclusions: Results of the antidiabetic shows immense potential in animal models and therapeutics and the antibacterial screening suggests conspicuous and potent putative role in the therapeutics of a vast plethora bacterial infections that need to be corroborated for the expansion of future prospective in vivo studies with larger sample size.
Case series on anti-melanoma differentiation-associated gene 5+ dermatomyositis associated with interstitial lung disease
Authors: Pranathiya Koya , Anusha Are , Sam Kezia , Manda Anusha
Published: February 2023

Dermatomyositis (DM) associated with anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody is a rare autoimmune disease. Anti-MDA5, also known as anti-CADM-140 antibodies. DM affects the skeletal muscle, skin, joints, and lungs and is a form of idiopathic inflammatory myopathy (IIM). All the 5 dermatomyositis MDA5+ positive patients had rapidly progressive interstitial lung disease (RP-ILD). DM is classified into 2 types, classic dermatomyositis (CDM) and clinically amyopathic dermatomyositis (CADM). Anti-MDA5 antibody-positive as RP-ILD without signs of DM or CADM. RP-ILD in patients with CADM associated with antibodies to MDA5 has a high mortality rate. MDA5+ DM is diagnosed by DM rashes (Gottron’s papules or Gottron’s sign and heliotrope rash) and a positive anti-MDA5. RP-ILD includes acute/subacute interstitial pneumonia, which is a progressive deterioration associated with ILD. Immunosuppressives are effective agents for the treatment of anti-MDA5-positive RP-ILD of CADM.
Review: recent trends in management of oral lichen planus
Authors: Garg Shubhangi , Malik Sangeeta S. , Kamarthi Nagaraju , Goel Sumit , Gupta Swati
Published: February 2023

Oral lichen planus (OLP) is a chronic mucocutaneous inflammatory disease, associated with altered cell‐mediated immunological function. It has been characterised by long‐term evolution, repeated exacerbations, sometimes painful and resistant to treatment, or even all of these. OLP significantly affects quality of patient's life. There is a higher risk of malignant transformation accompanied with OLP and similar appearing oral lichenoid lesions. Current OLP therapy aims at eliminating all mucosal‐related lesions reduce symptomatology and decrease the risk of oral cancer. This review summarizes recent treatment modalities used in the management of OLP which includes corticosteroids, immunomodulatory agents, retinoids, ultraviolet irradiation and/or laser therapy, herbal remedies. In addition, focus is also given upon adopting holistic approach in such patients by emphasizing on stress management.
A case of Alport syndrome
Authors: Kaluvai Sai Indraneel , K. V. Rajalakshmi , Y. Dayanandan
Published: February 2023

Alport syndrome is an inherited disease characterized by progressive renal failure, hearing loss and ocular abnormalities. It usually manifests as progressive form of glomerular disease that is often associated with sensorineural hearing loss and ocular abnormalities. The defects are caused by mutations in the genes that code for type IV collagen's alpha chains, which are the most important structural elements of basement membranes, including those in the kidney, cochlea, and eye. We present a 37-year-old female known case of chronic kidney disease on medical management came with complaints of shortness of breath and loss of appetite. Her 2 children are also affected. Her renal biopsy showed glomerulosclerosis, splitting, lamination of basement membrane. Pure tone audiometry revealed bilateral sensorineural hearing loss. Slit lamp examination showed bilateral lenticonus and distant direct ophthalmoscopy revealed oil droplet sign which confirms lenticonus with dot and fleck retinopathy. Hence diagnosed as a previously undetected case of Alport syndrome.
An unusual manifestation of scrub typhus presenting with splenic infarct: a case report
Authors: Arora Anuj , Nawahirsha Sultan , Kumar Babu , Krishnan Durga
Published: February 2023

Scrub typhus has a wide range of clinical presentation varying from mild symptoms like fever, chills, headaches, myalgias, gastric ulcerations and hepatitis to more fatal conditions like pneumonia and encephalopathy caused by disseminated vasculitis with splenic infarct being a rare complication. We report a case of 50-years old male with scrub typhus who presented as multiple splenic infarcts.
Intracranial tuberculoma in human immunodeficiency virus-infected patient: a case report
Authors: Seputra Desak M. C. S. , Suhendro Amelia P. , Sumada I. Ketut , Yuliani Desie
Published: February 2023

Intracranial tuberculoma is one of the most devastating forms of Mycobacterium tuberculosis infection, presenting in 1% of all tuberculosis cases. This condition is significantly associated with high morbidity and mortality and frequently occurs in immunocompromised patients such as patient with human immunodeficiency virus (HIV) infection. Symptoms of intracranial tuberculoma include headache, nausea, vomiting, ataxia, diplopia, hemiparesis, and seizure. We reported a 34-years-old male patient presented with progressive left side weakness for 1 month prior to admission. Patient also complained of intermittent fever, headache, productive cough, night sweats, and unintentional weight loss. On neurological examination, power of left upper and lower limb was 3. Patient had a positive test result for HIV serologic examination. Chest X-ray showed infiltrate in the apical segment of right lower lobe of the lung. Mycobacterium tuberculosis was found on sputum gene expert examination. Head computed tomography (CT) scan showed multiple hypodense lesions with contrast enhancement in right caudate nucleus and right lentiform nucleus, suggestive for tuberculoma. Patient was treated with fixed-dose combination of antituberculosis, corticosteroid, and other symptomatic medication and showed a significant clinical improvement.
A rare presentation of primary apla and pulmonary thrombolism
Authors: Chinnasamy Vignesh , Kumar K. Mahendra , T. Gnanadeepan
Published: February 2023

Antiphospholipid syndrome (APS) is a state of hypercoagulation, causing thrombus in artery, vein and capillaries, with or without obstetrical events with the presence of autoantibodies, which includes lupus anticoagulant, anticardiolipin antibodies and anti-β2-glycoprotein 1 antibodies. It has variable clinical presentations such as vascular thrombosis and obstetrical complications, pulmonary thromboembolism (PTE), pulmonary hypertension, and acute respiratory distress syndrome. Hereby we presented a case of young male who came to our hospital with hemoptysis and isolated pulmonary embolism, with the background of APS which is rare. Hemoptysis and pulmonary thromboembolism both being fatal emergencies requiring completely different management methods.
Prevalence and pattern of adverse events following immunization to Covishield vaccine in a tertiary care hospital: a cross-sectional analytical study
Authors: Sumedhan Suji V. , Gopinath Sangeetha , Gopan Karthika
Published: February 2023

Background: The COVID-19 pandemic has emerged as the most important public health issue in the past two years. Multiple preventive and treatment modalities are being tried to contain this pandemic. Several countries have documented vaccines as a vital tool to combat this pandemic across the globe. Hence, we tried to evaluate the adverse events following immunisation at the study site following Covishield vaccination among front-line health workers in our tertiary care hospital.
Methods: A cross-sectional descriptive study was planned in the vaccination site of our institute, where all details of the frontline workers who were vaccinated for the Covishield vaccine were included, and they were followed up to study the prevalence and pattern of AEFIs. The participants were observed for 30 minutes after the jab and were reviewed/called upon on the third day following immunization to gather information. The data was collected using a semi-structured questionnaire
Results: Our study included around 159 frontline workers and medical students who received their vaccination during the study period.  The mean age distribution was 24.3±7.6 years, with female predominance. We observed an AEFI prevalence of 33.3% among the study participants at the end of 30 minutes, while after 30 mins and during the next 3 days of follow-up by our staff, we observed that the prevalence increased to 80%. We observed that the commonest AEFI observed at 30 minutes and during the 3 days follow up was tenderness/pain, fever, body ache and light-headedness. Only 4% of the patients required hospitalisation following AEFI.
Conclusions: Around 1/3rd of our study participants reported AEFI following vaccination during the first 30 minutes of observation which is much higher than the national average.
Large benign cystic teratoma of the ovary: a case report
Authors: Okoye Chukwunonso Nnamdi , Alabintei Ogheneochuko Magdalene , Oriji Peter Chibuzor , Awotundun Benjamin Olusegun , Adeniran Aderonke , Mbooh Romeo , Suobite Ephraim Ayibakuro
Published: February 2023

Cystic teratoma is the most common ovarian germ cell tumour. It is made up of ectoderm, mesoderm, and endoderm that eventually become hair, muscle, teeth, or bone. These tumors are usually benign. A 30-year-old para 6+0 with 2 living children, presented to the gynaecological clinic of the Federal Medical Centre, Yenagoa with complaints of abdominal swelling of four-year duration. Physical examination revealed a young woman, in no obvious distress. Her abdomen was uniformly enlarged, moved with respiration and non-tender, smooth, firm, mobile in two planes and not attached to underlying structures or overlying skin. It was dull to percussion, and there was ascites demonstrable by fluid thrill. Report of abdominopelvic ultrasound scan revealed a huge cystic mass arising from the right adnexae, and extending into the abdomen. She subsequently had right ovarian cystectomy, and was discharged home on the 3rd day post-operation. Histopathology report revealed a diagnosis of benign cystic teratoma. She is presently on follow-up. Ovarian cyst is commoner among the women of reproductive age-group. Routine pelvic examination is advised to enable early detection and prompt management of this condition. Prognosis is usually good when the cyst is benign.
Security Practices and its Correlates to Incident Command System on Safety Procedures
Authors: L. Estremera Dr. Michael , D. Fruto, PA Major Joel
Published: February 2023

This paper sheds light to the crucial role being played by army officers not just in the site of interest which is Philippines but also in almost all countries taking into consideration security practices and Incident Command System on safety procedures. In effect, as to the significant differences in the assessment of the respondents on the internal security practices of the Philippine Army considering variables of the present study where p values are generally higher than the level of significance, has resulted to the acceptance of the null hypothesis of no significant difference. This presupposes that intervening variables move in a somewhat the same direction but different magnitude. In the context of the current academic piece, this implies that respondents are performing satisfactorily their functions in acquiescence to the commanding authority and is compliant with ICS. After careful scrutiny of data, researchers recommend that Philippine Army shall issue relevant policies for authorization of its personnel to visit other offices nationwide. On operational security, the P.A.’s treasury office or finance office shall be secured properly by security personnel or military police. For future researches, relevant studies may be conducted to a widened scope to improve the internal security practices of the P.A. exploring other relevant variables and its compliance to the security management system. As for international security standards, benchmarking on safety practices and procedures among allied countries be cultivated and reinforced to ameliorate its treaty and ensure its international resiliency against potential threat both natural and man-made.
Caracterização de dimensões para avaliação da maturidade digital a partir de uma metodologia colaborativa
Authors: Silva José Luiz da , Silva Simone Vasconcelos
Published: February 2023

Este estudo consiste em caracterizar dimensões estruturadas a partir de uma revisão sistemática de literatura, com o objetivo de proporcionar maior efetividade na elaboração e aplicação de um modelo de maturidade digital genérico, a fim de auxiliar as organizações no processo de transformação digital por meio de dimensões estruturadas em conformidade com o domínio. O estudo foi conduzido por um processo Delphi, por permitir o desenvolvimento de uma metodologia participativa de abordagem coletiva com um grupo alargado de participantes de diferentes áreas de atuação relacionados ao tema abordado. Como resultado foi possível perceber a conformidade das dimensões apresentadas no que tange ao processo de avaliação da maturidade digital, capaz de oferecer uma avaliação avançada e diagnóstica de acordo com a atividade de cada organização a ser avaliada.
Combining Epigenetic and Immunotherapy in Cancer: Molecular Mechanisms
Authors: Meiliana Anna , Wijaya Andi
Published: February 2023

BACKGROUND: Immunotherapy, particularly the idea of immune checkpoint blockage is currently draw much attention in cancer treatment. It has been approved as an adjuvant, however, it cannot be a single cancer treatment.CONTENT: The discovery of the basic ligand-receptor interactions between immune and cancer cells inside the tumor microenvironment has led to the current interest in immunotherapy, specifically immune checkpoint inhibition. Different ligands produced by cancer cells interact with immune cells' surface receptors, activating inhibitory pathways, such programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1), that cause immune cells to become immunologically tolerant. On the other side, epigenetic modulators also play a critical role in enhancing the tumor microenvironment and regaining immunological recognition and immunogenicity. Some findings showed that such immune suppression can be reversed through various mechanisms involving antigens pathways, immune genetic, and epigenetic pathways. These findings have created a very encouraging foundation for research on the combination of epigenetic and immunotherapeutic drugs as cancer treatments.SUMMARY: The effectiveness of this suggested paradigm can only be demonstrated by clinical studies. Epigenetic treatment might replace immune checkpoint therapy as a powerful new cancer care technique that is generally well tolerated and should be proven with adequate clinical trials.KEYWORDS: epigenetics, immunotherapy, PTM, DNMT, HDAC, immune check point
Well-organized Granuloma Lymphadenitis Tuberculosis Expressed Lower Macrophage Migration Inhibitory Factor (MIF) Score Compared to the Poorly-organized Granuloma
Authors: Kadriyan Hamsu , Djannah Fathul , Habib Philip , Cahyawati Triana Diah , Siddik Nurhidayati
Published: February 2023

BACKGROUND: The case of extra-pulmonary tuberculosis (EPTB) is common and the most type of extra-pulmonary tuberculosis found is lymphadenitis TB (LnTB). Macrophage migration inhibitory factor (MIF) is correlated with TB, and low level of MIF was correlated to Mycobacterium TB bacteremia. Deficiency of MIF macrophage is known to be correlated to the increased of a lung pathology; however, its role on pathogenesis LnTB remains unclear. Hence, this study was conducted to analyze the correlation of MIF in several type of granuloma organization in LnTB.METHODS: Block paraffin of the lymphoid tissue infected with M. Tuberculosis were analyzed with immunohistochemistry (IHC) to assess the MIF expression, by counting the immunoreactivity score (IRS) according to the intensity of stained cells and the level of staining. The histopathology type of LnTB was divided into well-organized granuloma (WOG) and poorly-organized granuloma (POG) based on the granuloma characteristics.RESULTS: Among 100 tissues samples that fulfilled the study criteria, WOG was found in 51% cases. MIF was expressed mild positive in 21% samples, on the other hand, 79% was not expressed. There was a significant difference of MIF negative, as was found in 98% of WOG group while only 59% was found in POG group (p<0.001).CONCLUSION: There is a significant correlation between MIF expression with the type of granuloma organization in LnTB. The expression of MIF in WOG group is mostly negative, as well as a half of the POG group. This results may suggests that MIF plays a role in the pathogenesis of granuloma formation in LnTB.KEYWORDS: MIF, lymphadenitis TB, WOG, POG, immunohistochemistry
Zaangażowanie Zgromadzenia Salezjańskiego na rzecz rozwoju społecznego. Wczoraj i dziś
Authors: Dal Covolo Enrico
Published: February 2023

This article applies to the social dimension of the Salesian mission. Subject was, chronologically, included in the three points. The article begins with the presentation of the social aspect of the life of the Founder of the Salesians – St. John Bosco. Then it moves to the activity of Bl. Michael Rua and the contribution of other saints, the servants of God and candidates for sainthood from the Salesian Family. The last point indicates a variety of pro-social activities in the above mentioned areas in recent years. This article, of which the author is the Postulator for the Causes of Saints of the Salesian Family, is a contribution to the celebration of 150th anniversary of the Salesian Congregation (1859 – 2009).