bluuebunny/crossref_metadata_2025 huggingface dataset:
Pessoas, indivíduos e ciborgues
Authors: Escoura Michele
Published: April 2021

O método comparativo durante muito tempo serviu de base para a discussão metodológica na Antropologia. A partir deste pano de fundo, Marilyn Strathern destacou- se como um nome fundamental no campo teórico e fez de suas etnografias na Melanésia uma chave de comparação e contraposição ao ocidente. Escrevendo no entremeio dos anos de 1980 e entre as críticas epistemológicas pós-modernas que abalaram os alicerces das Ciências Humanas, a antropóloga apoiou-se em um movimento teórico-metodológico que colocou em suspensão não só dados etnográficos, mas também conceitos fundantes da disciplina antropológica. Neste artigo retomamos o percurso metodológico de Marilyn Strathern para evidenciar suas estratégias de análise e os deslocamentos das noções de indivíduo e sociedade que ela provocou ao aproximar a antropologia e o feminismo. Ao mesmo tempo, buscamos colocar em prática seu exercício metodológico e ao trazer Donna Haraway e Judith Butler para o diálogo, buscamos evidenciar como as noções de conexões parciais, hibridismo e criação de ciborgues podem revelar expansões e alargamentos na própria teoria stratherniana.
O predomínio da ontologia biocientífica
Authors: Paschoalotte Leandro Módolo
Published: April 2021

Este trabalho pretende trazer à baila algumas das atuais investidas biocientíficas na construção de narrativas e explicações para questões que tradicionalmente se constituíram no âmbito das Ciências Humanas. Visa, assim, apreender o que há de efetivamente novo em seus significados histórico-sociais. Para tanto, concentraremos atenção especial às respostas ontológicas que as biociências vêm dando à questão “O que é o homem?”. A ideia é apresentar as obras Armas, Germes e Aço e Tábula Rasa de Jared Diamond e Steven Pinker, respectivamente, autores consagrados no campo das Ciências Naturais contemporâneas, tendo em vista, entre outras características, a crítica que desferem a duas importantes características do campo do saber “pós-moderno”: o seu caráter antiontológico e seu fundamento antimetanarrativo. A ideia por nós defendida é de que a lacuna teórica aberta durantes as décadas de 70 e 80 pelo discurso pós-modernista foi uma das responsáveis pela disseminação da ontologia-biocientífica.
Apresentação
Authors: Paniz Flávia , Oliveira Gláucia Silva Destro de
Published: April 2021

A proposta de organizar este dossiê surgiu no segundo semestre de 2016, como forma de criar um registro das diferentes perspectivas sobre os acontecimentos ocorridos ao longo do ano, e que pudesse ser utilizado como apoio nas pesquisas e reflexões futuras sobre este período, que ficou historicamente marcado pelo processo de votação do impeachment da ex presidenta eleita Dilma Rousseff, seguido de seu afastamento; pelos protestos contra a realização da copa do mundo; e a prisão de Rafael Braga, um catador de material reciclável que portava uma garrafa de produto de limpeza no contexto dos protestos no Rio de Janeiro. Estes últimos fatos, juntamente com o desaparecimento do pedreiro Amarildo de Souza em 2013 e o assassinato de Claudia Silva Ferreira em 2014, escandalizaram a situação de encarceramento em massa e genocídio da população negra e periférica e o processo de precarização no ensino público no país.
O corte e a corte
Authors: Silveira Ana Cláudia Lopes , Pinheiro Hyury , Pagan Maria Elisa Perez , Borges Mariana Toledo , Costa Nathalia Rodrigues da , Queiroz Pedro Henrique Santos
Published: April 2021

O objetivo deste texto é contribuir para o debate sobre os cortes no orçamento  da Universidade Estadual de Campinas propostos pela reitoria no ano de 2016. Pretendese refletir sobre tal contingenciamento à luz da estrutura orçamentária em geral. Primeiro, apresenta-se o quadro atual do financiamento da Universidade Pública, e, particularmente, da Unicamp. Em seguida, discute-se esse quadro tendo em vista a estrutura tributária mais geral e das soluções de resolução apresentadas para o déficit orçamentário. Buscamos aqui pensar esses cortes no orçamento relacionando-os à atual conjuntura econômica, sem perder de vista a estrutura do financiamento do ensino universitário público. Com essa reflexão, pretendemos trazer mais subsídios para o debate sem abrir mão das demandas em favor de políticas de financiamento e de um projeto de ensino democrático e a serviço do público.
Relações familiares, gênero e o grande contrário
Authors: Sechinato Juliana Spagnol , Sega Rodrigo Fessel
Published: April 2021

O recente processo deimpeachmentda presidenta Dilma Rousseff e a tomada presidencial de Michel Temer, em 2016, não foi consenso entre os brasileiros. Participando cotidianamente do debate político marcado por forte estigmatizações sociais, por vezes, tratávamos e tratamos o outro como um rival. Neste ambiente polarizado, muitas vezes, a estratégia dos sujeitos foi de ridicularizar, excluir e/ou negar o outro. Nesse sentido, este artigo é um esforço em compreender este período de atropelamentos políticos que estamos vivenciando e sentindo no cotidiano quando dentro da família temos que conviver com um “grande contrário” em tempos de crise; em revelar um conflito latente com aqueles que amamos e que esse cenário de crise não poupou. Partimos de experiências e dos relatos cotidianos para entender essas tensões políticas com tonalidades autoritárias que se acomodaram no ambiente familiar quando hostilidade e amor, enfim, se confundiram. Destacamos, ainda, as assimetrias de gênero no seio e no conflito familiar em que os estereótipos emergem do conflito político, para pensar como a negação do outro, ao mesmo tempo em que pode representar o salvamento de si, não o faz sem causar sofrimento no deslocamento e na suspensão destatus na cédula familiar.
A chegada
Authors: Mamed Letícia Helena
Published: April 2021

Ensaio fotográfico da chegada dos haitianos ao Brasil.
Parliamentary Elections in Kazakhstan
Authors: Ionova E.
Published: April 2021

Following the results of the regular elections to the Mazhilis in January 2021, the ruling Nur Otan party retained its leadership in the lower house of parliament. However, the other two parties, which broke the 7% barrier, strengthened their positions, gaining several new seats. A feature of the 2021 elections was that they were held taking into account a certain liberalization of the country's electoral system. In particular, the constitutional rights of the Mazhilis which received the right to approve the new government were expanded, the institution of parliamentary opposition was legislated, and a 30% quota for women and youth was introduced. In addition, the ruling party introduced the practice of primaries for the first time.
Chinese tourists - are they an opportunity for the Slovene and Croatian tourist industry?
Authors: Raspor Andrej , Kobal Tanja , Rodič Blaž
Published: April 2021

The purpose of this article is to determine the opportunities related to increase in the number of Chinese tourists travelling abroad, particularly for Slovenia and Croatia. Research was conducted by studying the current publications, gathering and researching empirical statistical data and examination of case studies. Article presents the results of one of the first systematic scientific researches on this topic in the region. The appeal of Slovenia as a desirable destination has intensified after becoming a member of the Schengen Zone. Croatia, however, will become even more attractive after joining the EU. However, it is necessary to introduce certain improvements to the public administration procedures and logistics. Within their region, both Slovenia and Croatia have (1) rich and distinctive cultural heritage, (2) well-developed gaming and shopping tourism, (3) good logistical links with China and other Central European countries. Cooperation between these two countries in entering the Chinese market would increase the impact and reduce the marketing and transport costs.
The idea of destination brand licensing and the question of its effectiveness
Authors: Zemla Michal
Published: April 2021

Purpose – Destination branding is one of the most popular topics among tourism destinations researchers and practitioners however recent research revealed that it doesn’t have a clear concept. The purpose of presented paper is to enhance the destination branding theory by introducing some new elements taken from other popular concepts used in destination management into destination branding theory. The concept of destination brand licensing was undertaken as a response to several critical arguments raised against the existing idea of destination branding. However the concept is not completed and practical examples presented so far need scientific background to prepare some guidelines on successful procedure for implementing destination brand licensing. The aim of the paper is pointing out some crucial elements which are conditions for effective implementing of destination brand licensing. Design – Five main areas were discussed, namely: the proper definition of the product, the brand name, the nature of cooperation and network, financial stability and the scope and the nature of promotional actions. The structure of the paper follows this division. After introduction and presentation of destination branding and destination brand licensing concepts further chapter are devoted the five presented problem areas. At the end, there is a chapter in which effectiveness of destination brand licensing procedure is discussed. Approach and methodology – The paper is theoretical with limited use of case study approach. Within the frame of those five areas several dilemmas and potential problems were presented on the basis of several practical implementation examples of destination brand licensing ideas from different European countries. Research findings and originality – Apart from the five problem areas, three overall effectiveness indicators were proposed. These are: increased volume of tourism movement, improvement in destination image and enhancement of local stakeholders for better cooperation. However both, problem areas and indicators should be perceived as initial proposal and further discussion is expected.
Potential of non-Saccharomyces yeast for improving the aroma and sensory profile of Prokupac red wine
Authors: Karabegović Ivana , Malićanin Marko , Danilović Bojana , Stanojević Jelena , Stamenković Stojanović Sandra , Nikolić Nada , Lazić Miodrag
Published: April 2021

This work aimed to analyse the effect of non-Saccharomyces yeasts on the volatile composition, aromatic profile and sensory properties of wine made from autochthonous Serbian grape variety Prokupac (Vitis vinifera). Fermentation was performed with two commercial yeasts, Metschnikowia pulcherrima and Torulaspora delbrueckii, in pure and sequential fermentation with Saccharomyces cerevisiae. The standard analysis of produced wines indicated that the application of both non-Saccharomyces yeast (in pure or in sequential fermentation) significantly reduces the content of alcohol when compared to the control. The use of M. pulcherrima in both pure and sequential fermentation resulted in a higher content of different groups of polyphenols, anthocyanins and flavonoids or better colour characteristics compared to the wines obtained in fermentations with T. delbrueckii. HS-SPME GC/MS analysis revealed the presence of 27 different compounds in the wine samples, with higher alcohols and ethyl esters being the most dominant. It was proven that the presence of non-Saccharomyces yeasts in the initial stage of fermentation with later inoculation with S. cerevisiae contributes to increased complexity of the wine, as well as increased higher alcohol content and total extracts. Wines produced from sequential fermentation with T. delbrueckii showed floral and spice attributes, probably due to 1-pentanol and 2-phenylethanol detected in the wine, as well as to the large amount of ethyl acetate. The use of M. pulcherrima in pure fermentation resulted in wines with the lowest sensorial characteristics (i.e., lacking fruity and floral aroma) probably due to the lowest relative contribution of ethyl esters. The control wine in this study (from pure fermentation with S. cerevisie), had the most intense ‘red berries’ and ‘black berries’ note and low intensity of spices or vegetable aroma, which may be explained by the highest relative contribution of ethyl octanoate and ethyl decanoate. The PCA results also clearly differentiated the analysed samples produced in the sequential, pure and control fermentation trials, leading to the conclusion that the aromatic profile of Prokupac wines produced in sequential fermentation was more complex compared to the wines produced in pure fermentation.
Vigenere Followed by Multiple Bit-Level Permutations to Encrypt a Color Image
Authors: Jarjar Abdellatif
Published: April 2021

The largest part of the image encryption algorithms operates on the pixel as a central element by implementing diffusion confusion and eventually a permutation. On the other side, a permutation applied at the bit level changes not only the pixel value, but also its location within the image. In this work, we will propose a new technology of medical and color image encryption, based on chaotic permutations acting at the bit level, and a diffusion confusion ensured by an application of the method of Vigenere largely improved and adapted to the subject. Simulations performed on a large number of images of different sizes and formats ensure that our method is not subject to any known attacks.
Using Lorentz Violation for Early Universe GW Generation Due to Black Hole Destruction in the Early Universe as by Freeze
Authors: Beckwith Andrew W
Published: April 2021

We are using information from a paper deriving a Lorentz-violating energy-momentum relation entailing an exact mo_mentum cutof as stated by G. Salesi . Salesi in his work allegedly defines Pre Planckian physics, whereas we restrict our given application to GW generation and DE formation in the first 10^-39s to 10^-33s or so seconds in the early universe. This procedure is inacted due to an earlier work whereas referees exhibited puzzlement as to the physical mechanism for release of Gravitons in the very early universe. The calculation is meant to be complementary to work done in the Book “Dark Energy” by M. Li, X-D. Li, and Y. Wang, and also a calculation for Black hole destruction as outlined by Karen Freeze, et. al. The GW generation will be when there is sufficient early universe density so as to break apart Relic Black holes but we claim that this destruction is directly linked to a Lorentz violating energy-momentum G. Salesi derived, which we adopt, with a mass m added in the G. Salesi energy momentum results proportional to a tiny graviton mass, times the number of gravitons in the first 10^-43 seconds
SCA Medium: A New Culture Medium for the Isolation of all Candida auris Clade
Authors: Ibrahim Ahmad , Peyclit Lucie , Abdallah Rim , Khelaifia Saber , Chamieh Amanda , Rolain Jean-Marc , Bittar Fadi
Published: April 2021

Candida auris is an emerging multidrug resistant yeast causing nosocomial infections and associated with high mortality in immunocompromised patients. Rapid identification and characterisation is necessary for its diagnosis and containing spread. In this study, we present a selective culture medium for all C. auris clades. This medium is sensitive with a limit of detection of 102 CFU/ml. The 100% specificity of SCA (Specific C. auris) medium is confirmed on a set of 134 Candida strains, 50 bacterial species and 200 human stool samples. Thus, this medium specifically selects for C. auris isolation from clinical samples, and allows studying its phenotypic profile.
Deep Learning Control for Digital Feedback Systems: Improved Performance with Robustness against Parameter Change
Authors: Alwan Nuha A. S. , Hussain Zahir M.
Published: April 2021

Training data for a deep learning (DL) neural network (NN) controller are obtained from the input and output signals of a conventional digital controller that is designed to provide the suitable control signal to a speciﬁed plant within a feedback digital control system. It is found that if the DL controller is suﬃciently deep (four hidden layers), it can outperform the conventional controller in terms of settling time of the system output transient response to a unit-step reference signal. That is, the DL controller introduces a damping eﬀect. Moreover, it does not need to be retrained to operate with a reference signal of diﬀerent magnitude, or under system parameter change. Such properties make the DL control more attractive for applications that may undergo parameter variation, like sensor networks.
Inhibition of p38 Mitogen-Activated Protein Kinase Impairs Mayaro Virus Replication in Human Dermal Fibroblasts and HeLa Cells
Authors: Sugasti Madelaine , Llamas-González Yessica Y. , Campos Dalkiria , González-Santamaría José
Published: April 2021

Mayaro virus (MAYV) hijacks the host´s cell machinery to effectively replicate. The mitogen-activated protein kinases (MAPKs) p38, JNK and ERK1/2 have emerged as crucial cellular factors implicated in different stages of the viral cycle. However, whether MAYV uses these MAPKs to competently replicate has not yet been determined. The aim of this study was to evaluate the impact of MAPKs inhibition on MAYV replication using primary human dermal fibroblasts (HDFs) and HeLa cells. Viral yields in supernatants from MAYV-infected cells treated or untreated with inhibitors SB203580, SP600125, U0126 or Losmapimod were quantified using plaque assay. Also, viral protein expression was analyzed using immunoblot and immunofluorescence. Knockdown of p38⍺/p38β isoforms was performed in HDFs using the PROTACs molecule NR-7h. Our data demonstrated that HDFs are highly susceptible to MAYV infection. SB203580, a p38 inhibitor, reduced MAYV replication in a dose-dependent manner in both HDFs and HeLa cells. Additionally, SB203580 significantly decreased viral E1 protein expression. Similarly, knockdown or inhibition of p38⍺/p38β isoforms with NR-7h or Losmapimod, respectively, affected MAYV replication in a dose-dependent manner. Collectively, these findings suggest that p38 could play an important role in MAYV replication and could serve as a therapeutic target to control MAYV infection.
Analisa Kekuatan Struktur Barge Pada Proses Load Out Offshore Module (Top Side) dengan SPMT
Authors: Palippui Habibi , Ramadhan Sahwan
Published: April 2021

Salah satu proses yang kritikal ketika fabrikasi offshore yaitu proses transfer offshore module (Top Side) dari atas jetty ke atas transportation barge atau sering disebut Proses Load Out. Salah satu analisa yang dibutuhkan untuk memastikan proses load out berjalan dengan lancar dan aman yaitu analisa kekuatan struktur barge pada saat proses load out tersebut terjadi yaitu dimana dilakukan pengecekan terhadap kekuatan struktur barge apakah mampu menahan beban top side ketika terjadi transfer beban dari atas jetty ke atas transportation barge atau dari tepi barge sampai ke final lokasi. Untuk mendapatkan hasil yang akurat maka digunakan bantuan program komputer atau sering disebut dengan metode elemen hingga (Finite Element Analysis). Adapun software yang digunakan pada analisa ini yaitu StaadPro V8i dengan simulasi percobaan ada tiga module. Dari hasil analisa diperoleh kesimpulan bahwa simulasi percobaan module tiga memiliki  nilai maksimum von misses stress adalah 74,119 N/mm2, normal stress adalah 57,765 N/mm2, dan shear stress adalah 0,02279 N/mm2, dimana semua nilai tegangan tersebut dibawah tegangan izin atau dibawah batas maksimal yang disyaratkan AISC sehingga struktur barge tidak perlu diberikan tambahan penguatan baik internal maupun eksternal  karena masih aman dan mampu untuk menahan beban top side ketika load. Analisis dengan SPMT berpotensi menjadi patokan dalam dalam menganalisis kekuatan struktrur barge dalam proses load out offshore module (top side).
Potential of Water Extract of The White Frangipani (Plumeria acuminate) and Hibiscus (Hibiscus tiliaceus) Leaves Powder as Textile Natural Dyes
Authors: Mulyani Sri , Aristia Kris Siska , Sabrina Ardia Putri , Arfiah Afifatul , Niam Badrun
Published: April 2021

Synthetic dyes have a high environmental impact, especially on waters. The use of natural dyes for textiles provides new hope for ecological improvement. This article is to find out the yield of water extract of white frangipani (Plumeria acuminate) and hibiscus (Hibiscus tiliaceus) leaves-powder, as well as to find out whether the water extracts have potential as textile natural dyes. Natural dyes must have a good quality of fastness. For this reason, the color fastness tests for washing with a launder meter and colorfastness against rubbing with a crock meter are performed. Colorfastness is assessed by comparing color changes to washing with grayscale and color changes due to staining on fabric with staining scale. The rubbing test is carried out on the wet and dry cloth. Cotton and polyester fabrics are samples that will be colored. Fixers used to bind dyes are Al2(SO4)3, CaCO3, and FeSO4.H2O. The results show that the water extraction of hibiscus and white frangipani leaves powder gave a yield of 11% (w/w) and 27 % (w/w), respectively. The test of colorfastness against washing showed that both water extract of the white frangipani dan hibiscus leaves has a pretty good average quality in staining scale but less in grayscale. The test against rubbing shows that the type of fixer used affects the quality of the colorfastness, but in general, the water extract of white frangipani leaves gives better quality as a potential of natural dye than hibiscus leaves
Designing Calorimeter Made from Various Wastes
Authors: Farida Ida , Akbar Gilang Saeful , Aisyah Riri
Published: April 2021

A research has been conducted which aims to design a waste-based calorimeter as an alternative to measuring heat for chemistry practicum in schools. Research products developed through the steps of design-based research comprising the steps of analysis, design, and development. The resulting product is a waste-based calorimeter equipped with an automatic stirrer. The container to store the reagent solution on the calorimeter is made of Styrofoam, paper, plastic, melamine, PVC and bamboo. Optimization tool was conducted to determine the heat capacity of the calorimeter and the enthalpy of neutralization. The highest accuracy calorimeter value between 78-97%. Bamboo calorimeter has the highest accuracy value (97%). Styrofoam calorimeter has the lowest accuracy values (78%). Based on the results of the validation and feasibility test it can be concluded that the product is declared valid and feasible.
The Science Learning Material Using PjBL Model Integrated with Science, Technology, Engineering, and Mathematics (STEM) Approaches to Enhance Students' Communication Skills
Authors: Yamtinah Sri , Hariyanto Hariyanto , Sukarmin Sukarmin , Saputro Sulistyo
Published: April 2021

This study aims to develop a science learning material using PjBL model integrated STEM approaches to enhance students' communication skills. The method used is the 4D Research and Development (R&D) model and an experimental method for testing the effectiveness of the device. The study population was all VII class in one of the junior high schools in the South Tangerang region with samples taken using a random sampling technique of 76 people. The instrument used was a device feasibility test sheet and an observation skill communication sheet. The data obtained were then analyzed quantitatively and qualitatively. The results showed the components of the learning device in the form of syllabus, lesson plans, teaching materials and student worksheets, were very feasible to use with an average of 3.62. In addition, each item validity assessment instrument is also declared valid for use. The observed communication skills also increased from 1.59 to 3.15 with a gain value of 0.64 (medium category) for the experimental class. Meanwhile, the gain value for the control class is 0.005 (very low category). The difference in the gain value indicates that the learning device is effective in improving students' communication skills.
Lock operation improvements
Authors: Foltz Stuart , Hooks Daniel
Published: April 2021

The U.S. Army Corps of Engineers (USACE) owns or operates 236 locks at 191 sites (HQUSACE 2016). Although the locks at these sites generally perform reliably, more than half of these structures have surpassed their 50-year economic design life and as such, there are increasing concerns about their continued safe, reliable operation. This work was undertaken to review lock operating equipment, maintenance practices, records pertaining to accidents and equipment failures, and lighting systems; to identify alternative improvements to equipment and equipment maintenance practices; and to analyze and compare those alternatives to determine and recommend optimal solutions. This report documents some lessons learned, primarily to share information that others might find useful. Note that the recommendations in this report should not be viewed as policy, although some might be considered by those creating policy.
Classical and innovative methods of fatigue and fracture repairs in navigation steel structures
Authors: Christine Lozano , Guillermo Riveros
Published: April 2021

Most of the hydraulic steel structures (HSS) in the U.S. have reached or have past their design life, which leads to unsatisfactory performance. Welded connections with low fatigue resistance, poor weld quality, unanticipated structural behavior, or unexpected loading due to the deterioration of the design boundary conditions are the causes of fatigue cracking. The purpose of this report is to identify and evaluate the traditional and new methods used for fatigue and fracture repairs in navigation steel structures to restore their load carrying capacity and fatigue and fracture resistance. The final objective was to generate a guidance report comprising of recommended and more efficient repair methods for the different fatigue limit states observed in navigation steel structures.
Features of Mineral Crystallization at Different Stages of the Magmatism Evolution of the Gorely Volcano (Kamchatka): Data on Melt and Fluid Inclusions
Authors: Simonov V.A. , Dobretsov N.L. , Kotlyarov A.V. , Karmanov N.S. , Borovikov A.A.
Published: April 2021

––Studies of melt and fluid inclusions and minerals as well as computational modeling (based on the data on the composition of melt inclusions, clinopyroxenes, and amphiboles) gave an insight into the physicochemical parameters of magmatic systems during the evolution of the precaldera Pra-Gorely Volcano and during the subsequent formation of rock complexes of the Young Gorely Volcano. The estimated temperatures of crystallization of olivine, clinopyroxene, and plagioclase phenocrysts (1115–1260 °С) and amphibole (740–890 °С) are in agreement with the earlier published data on the magmatism of the Gorely Volcano. Computational modeling based on the compositions and homogenization temperatures of melt inclusions showed that the established depth interval of mineral crystallization (21.0–1.5 km) with pressures of 7.0–0.5 kbar can be divided into two ranges, 21–15 km and 9.0–1.5 km. Both the Pra-Gorely and Young Gorely volcanoes have magma chambers in these depth ranges. The Pra-Gorely Volcano is characterized by higher temperatures of mineral crystallization (1240–1190 °С) as compared with the Young Gorely Volcano (1190–1125 °С). The presence of primary fluid inclusions with low-density CO2 and of syngenetic primary melt inclusions in plagioclase of the Pra-Gorely Volcano indicates that the mineral crystallized from a heterophase melt. At the same time, the cores of plagioclase phenocrysts formed from a homogeneous melt. A drastic drop in pressure led to the phase separation of magma throughout the magma column (upper and lower chambers) and to the growth of zones saturated with CO2 fluid inclusions in the plagioclase crystals formed from a two-phase melt. The subsequent closure of the system and the disappearance of CO2 phase resulted in the growth of plagioclase from a homogeneous melt.
La intensidad de innovación y la competitividad de micro y pequeñas empresas exportadores de artesanía textil
Authors: Cutipa-Limache Alberto Magno , Escobar-Mamani Fortunato , Anchapuri Manuel , Valreymond-Tacora Darío
Published: April 2021

La escasa capacidad innovadora y competitiva de micro y pequeñas empresas —mype— induce solo a la sobrevivencia en el mercado, dada su mínima participación en el mercado internacional. El objetivo del estudio fue determinar la relación entre la intensidad de la innovación y la competitividad de mypes exportadores de artesanía textil de la región Puno, Perú. El procedimiento metodológico fue descriptivo-relacional con enfoque cuantitativo y diseño no experimental-transeccional. Se evaluaron 31 mypes exportadoras de artesanía textil de la región, representadas por sus gerentes, a quienes se les realizaron encuestas con dos cuestionarios de 20 ítems, se usó una escala tipo Likert de 1 a 4 alternativas de respuesta. Los resultados indican que existe una alta correlación directa y estadísticamente significativa en un 73 % —rho—, p = 0,000, a un nivel de confianza del 95 %, entre la intensidad de innovación y la competitividad. La correlación existente implica que, a mayor intensidad de innovación en producto, en mercados, en procesos y en modelo de negocio, es mayor la competitividad en calidad de producto, al igual que la productividad y el desempeño en el mercado de las mypes exportadoras del sector de artesanía textil. Se concluye que en tanto mejore la innovación, se impactará directamente la mejora de la competitividad con miras a ampliar los horizontes de mercado internacional, lo que debe traducirse en el desarrollo de la economía; además de ser compatible con las políticas públicas de crecimiento económico equitativo, competitivo y sostenible del Gobierno del Perú.
Quantitative Hydraulic-Fracture Geometry Characterization with LF-DAS Strain Data: Numerical Analysis and Field Applications
Authors: Liu Yongzan , Jin Ge , Wu Kan , Moridis George
Published: April 2021

Low-frequency distributed acoustic sensing (LF-DAS) has been used for hydraulic fracture monitoring and characterization. Large amounts of DAS data have been acquired across different formations. The low-frequency components of DAS data are highly sensitive to mechanical strain changes. Forward geomechanical modeling has been the focus of current research efforts to better understand the LF-DAS signals. Moreover, LF-DAS provides the opportunity to quantify fracture geometry. Recently, Liu et al. (2020a;2020b) proposed an inversion algorithm to estimate hydraulic fracture width using LF-DAS data measured during multifracture propagation. The LF-DAS strain data is linked to the fracture widths through a forward model developed based on the Displacement Discontinuity Method (DDM). In this study, we firstly investigated the impacts of fracture height on the inversion results through a numerical case with a four-cluster completion design. Then we discussed how to estimate the fracture height based on the inversion results. Finally, we applied the inversion algorithm to two field examples.

The inverted widths are not sensitive to the fracture height. In the synthetic case, the maximum relative error is less than 10% even when the fracture height is two times of the true value. After obtaining the fracture width, the fracture height can be estimated by matching the true strain data under various heights with a strong smooth weight. The error between the calculated strain and true strain decreases as the height is getting close to the true value. In the two field examples, the temporal evolutions of both width summation of all fractures and the width of each fracture show consistent behaviors with the field LF-DAS measurements. The calculated strain data from the forward model matches well with the field LF-DAS strain data. The results demonstrate the robustness and accuracy of the proposed inversion algorithm.
Digital Fracture Characterization at Hydraulic Fracturing Test Site HFTS-Midland: Fracture Clustering, Stress Effects and Lithologic Controls
Authors: Maity Debotyam , Ciezobka Jordan
Published: April 2021

In this case study, we apply a novel fracture imaging and interpretation workflow to take a systematic look at hydraulic fractures captured during thorugh fracture coring at the Hydraulic Fracturing Test Site (HFTS) in Midland Basin. Digital fracture maps rendered using high resolution 3D laser scans are analyzed for fracture morphology and roughness. Analysis of hydraulic fracture faces show that the roughness varies systematically in clusters with average cluster separation of approximately 20' along the core. While isolated smooth hydraulic fractures are observed in the dataset, very rough fractures are found to be accompanied by proximal smoother fractures. Roughness distribution also helps understand the effect of stresses on fracture distribution. Locally, fracture roughness seems to vary with fracture orientations indicating possible inter-fracture stress effects. At the scale of stage lengths however, we see evidence of inter-stage stress effects. We also observe fracture morphology being strongly driven by rock properties and changes in lithology. Identified proppant distribution along the cored interval is also correlated with roughness variations and we observe strong positive correlation between proppant concentrations and fracture roughness at the local scale. Finally, based on the observed distribution of hydraulic fracture properties, we propose a conceptual spatio-temporal model of fracture propagation which can help explain the hydraulic fracture roughness distribution and ties in other observations as well.
The Path in Behind and the Challenges in Front: A Methodological Synthesis of Iranian L2 Papers
Authors: Jahanbakhsh Akbar A. , Ajideh Parviz
Published: April 2021

The present study is a methodological synthesis aiming to evaluate the adherence of Iranian L2 papers to the study quality standards. Ten Iranian journals were selected based on the latest ranking of Iran’s Ministry of Science, Research, and Technology (MSRT), and all experimental papers (N = 367) published from their beginnings were explored for study quality with regards to sampling, design, statistical tests, reporting practices and data sharing, and visual presentation. In the evaluation of the papers, the protocols proposed by Gass and Plonsky (2011) and Pagout and Plonsky (2017) were moderated and some recent issues proposed by APA’s (2018) Journal Article Reporting Standards and some scholars (e.g., Hu & Plonsky, 2019; Khany & Tazik, 2019; Larson-Hall, 2017) were added. The results showed that while there were issues, like acceptable sample size, use of pre-testing, reporting descriptive and inferential statistics, and ensuring the reliability of instruments, that were acceptably adhered to quality standards, problematic areas existed in all five facets of quality, and the majority of them stayed constant or changed slightly over time. The shortcomings caused by such lack of adherence are discussed to identify the challenges in the way of improving the papers’ quality. Although the results are obtained from a specific context, the implications may be generalizable to other contexts where English is taught and researched as a foreign language.
Giant Genital Condyloma Acuminatum: A case report
Authors: Thakor Poojan , Badgurjar Mohit Kumar , Prajapati Giriraj , Saxena Pankaj , Parihar Suman
Published: April 2021

The giant condyloma acuminatum(GCA),also known as Buschke–Löwenstein tumor(BLT),is a type of human papilloma virus associated sexually transmitted infection. Various treatment options are available but best option amongst them is surgery. This case report present a GCA case in male with masses over lower abdomen and penile region where surgical resection is done, taking into account the high rate of recurrence and the significant potential of malignant transformation.
Experimental Investigation and Multi-Objective Optimization of Cryogenically Cooled Near-Dry Wire-Cut EDM Using TOPSIS Technique
Authors: Sampath Boopathi , Myilsamy Sureshkumar , Sukkasamy Sudhager
Published: April 2021

In this research, the mixing of compressed air with the minimum quantity of water is used as a dielectric medium and the cryogenically cooled molybdenum wire is used as a tool in wire-cut electrical discharge machining (WEDM) to encourage the eco-friendly production, called cryogenically cooled near-dry WEDM process. The nitrogen gas-cooled wire tool is utilized to cut the Inconel 718 alloy workpiece to prevent wire breakage and maintain enough electrical conductivity. The preliminary experiments were conducted to compare wet, dry, near-dry, and cryogenically cooled near-dry WEDM processes. It was revealed that cryogenic cooled near-dry WEDM is better performance than dry, near-dry WEDM except for the wet process. The systematic experiments of eco-friendly cryogenically cooled near-dry WEDM have been conducted to analyse the effect of input factors like spark current, pulse-width, pulse-interval, and mixing water flow rate on material removal rate (MRR) and surface roughness (SR) using Box–Behnken method. The fitted models and response surface graphs were developed to analyse the influences of input factors on each response parameter. It was concluded that MRR and SR of cryogenically cooled near-dry WEDM are increased by maximizing spark current, pulse-width, and flow rate, conversely, both responses were decreased by increasing pulse-interval. The technique for order of preference by similarity to ideal solution (TOPSIS) technique has been applied to predict the best combination of input factors for satisfying the optimal values of both responses.
Performance Analysis of MAC Layer Protocols for WSN with Considering the Effects of Hidden Node Problem
Authors: Kaeed Kaeed Ketab , Alabady Salah Abdulghani
Published: April 2021

The authors have requested that this preprint be removed from Research Square.
In - Vivo Conversion of Astrocytes to Neuroblasts in the Injured Spinal Cord
Authors: Ataei Maryam Lale , Karimipour Mohammad , Shahabi Parviz , Soltani-Zangbar Hamid , Pashaiasl Maryam
Published: April 2021

Direct astrocyte reprogramming to neural progenitor cells and promotion of neurogenesis is considered as an alternative approach to replace the lost neurons in the spinal cord injury(SCI). Herein, we used the human amniotic fluid mesenchymal stem cells (hAF-MSCs) and their conditioned medium (CM), to investigating their ability to reprogramming astrocytes to neuroblasts following SCI. 54 adult rats were randomly divided into 9 groups (n = 6), included: Control, SCI, (SCI + DMEM), (SCI + CM), (SCI + MSCs), (SCI + Astrocyte), (SCI + Astrocyte + DMEM), (SCI + Astrocyte + CM) and SCI + Astrocyte + MSCs). Following laminectomy and SCI induction, DMEM, CM, MSCs and Astrocytes were injected. Wester-blot was performed to explore the levels of the Sox2 protein in the MSCs-CM. The immunofluorescence staining against DCX and GFAP was done. Finally, Basso-Beattie-Brenham (BBB) locomotor test was conducted to assess the neurological outcomes. Our results showed that the MSCs through juxtacrine and paracrine mechanisms induced the promotion of the endogenous neuroblasts and the decline of astrocytes. Moreover, in the present research, MSCs and CM could convert the transplanted human astrocytes to neuroblasts in the spinal cord injury. Taken together, our data indicate the MSCs via juxtacrine and paracrine pathways could direct the spinal cord endogenous neural stem cells(NSCs) to the neuroblasts lineage rather than astrocytes as well as induce reprogramming. Ultimately, MSCs could reverse the neurobehavioral deficit in the SCI. The striking output in our study was the capability of the MSCs in the reprogramming of the astrocytes to neuroblasts via juxtacrine and paracrine pathways in the In-vivo condition.
Epigenetic Regulation in Myelodysplastic Syndrome as A Consequence of A MicroRNA Dysregulation.
Authors: Avenoso Daniele , Squillario Margherita , Barla Annalisa , Verri Alessandro , Carminati Enrico , Nurra Clara , Todisco Elisabetta , Gigli Federica , Bertolini Francesco , Gregato Giuliana , Poletti Claudia , Miglino Maurizio
Published: April 2021

The myelodysplastic syndromes are a group of diseases characterized by impairment in hemopoiesis and variable tendency to progress to acute myeloid leukemia. Recent data regarding the MDS pathogenesis highlight alterations in several compartments of DNA replication, cell cycle control, and gene expression machinery. As previously reported, miRNA families are involved in MDS pathogenesis. Also, different miRNAs have been characterized in AML and MDS and allow the identification of prognostic risk categories independent from the revised international prognostic scoring system (R-IPSS). Herein we report the results and the possible scenarios regarding pathogenesis and disease progression secondary to the evidence of considerable gene network derangement following miRNA evaluation in a cohort of patients.
Long-Term Outcomes of Initial Trabeculectomy in Glaucoma Associated with Granulomatous and Non-Granulomatous Uveitis
Authors: Almobarak Faisal A. , Alharbi Ali H. , Aljadaan Ibrahim , Aldhibi Hassan
Published: April 2021

Purpose

To evaluate the outcomes of initial trabeculectomy in granulomatous and non-granulomatous uveitis.
Methods

Retrospective comparative study of 68 eyes that underwent an initial trabeculectomy.
Results

The mean follow-up was 74.18 and 74.86 months in both groups (p = 0.95). The intraocular pressure decreased from 40.03 mmHg (± 7.2) and 36.48 mmHg (± 11.3) to 14.00 mmHg (± 6.2) and 13.48 mmHg (± 5.7), the number of medications decreased from 3.73 (± 0.7) and 3.58 (± 0.9) to 1.00 (± 1.4) and 1.13 (± 1.4) on the last follow-up (p < 0.01) in the granulomatous and non-granulomatous groups, respectively. More eyes in the granulomatous uveitis group developed delayed postoperative complications like cataract, transient hypotony and glaucoma progression. Success rates were 64.9 and 71.0%, while failure rates were 35.1 and 29.0% in both groups (p = 0.84).
Conclusions

Trabeculectomy seems to have comparable IOP control and survival in granulomatous and non-granulomatous uveitis. Nevertheless, more eyes in the granulomatous uveitis group developed late onset complications.
Composition and Diversity of Endophytic Bacterial Community in Seeds of Upland Rice Resources from Different Origin Habitats in Yunnan Province of China
Authors: Wang Zhishan , Zhu Yongqiang , Li Ni , Sun Biqi , Liu Hai , Zheng Huajun , Wang Weiping , Liu Yang
Published: April 2021

Upland rice has the characteristics of strong drought tolerance and wide adaptability. Cultivating upland rice with high yield and high quality can solve the contradiction between food shortage, water shortage, and population increase in countries all over the world, and is of great significance to the sustainable development of agriculture. This study aims to reveal the "core microbiota" of the endophytic bacteria in upland rice seeds in the Yunnan Province of China by examining their diversity and community structures. Through the correlation analysis with upland rice habitat environmental factors, the effects of climate and altitude on the structure and diversity of endophytic bacterial community in upland rice seeds were further revealed. In this study, high-throughput sequencing technology based on the Illumina Miseq platform was used to investigate the structure and diversity of endophytic bacterial communities using 12 upland rice variety seeds from different areas in Yunnan Province of China as materials. Here, 39 endophytic OTUs (0.68%) were found to coexist in all samples. At the phylum level, the first dominant phyla in the 12 seed samples were Proteobacteria (66.92–99.98%). At the genus level, Pantoea (9.75–99.24%), Pseudomonas (0.11–37.24%), Curtobacterium (0.01–19.90%), Microbacterium (0.01–14.95%), Methylobacterium (0.40–5.86%), Agrobacterium (0.01–4.53%), Sphingomonas (0.04–1.56%), Aurantimonas (0.01–1.45%) and Rhodococcus (0.11–1.09%), which represent the core microbiota in upland rice seeds, served as the dominant genera that coexisted in all the upland rice seeds tested. Environmental factors such as temperature, precipitation and altitude have great influences on the structure of endophytic bacterial community in upland rice seeds. This study is of great significance to explore the relationship between upland rice and its endophytic bacteria and to tap the resources of drought-tolerant bacteria to improve the yield of local upland rice.
Dysglyceamia after COVID-19 pneumonia: a six-month cohort study.
Authors: Molinari Chiara , Laurenzi Andrea , Caretto Amelia , Rovere-Querini Patrizia , Ciceri Fabio , Lampasona Vito , Scavini Marina , Piemonti Lorenzo
Published: April 2021

Aim. The aim of this study was to understand whether the dysglyceamia associated with SARS-CoV-2 infection persists or reverts when the viral infection resolves. Methods. We analyzed fasting blood glucose (FBG) after hospital discharge in a cohort of 621 adult cases with suspected COVID-19 pneumonia. Results. At admission,, 18.8% of the patients in our cohort had pre-existing diabetes, 9.3% fasting glucose in the diabetes range without a prior diagnosis (DFG), 26% impaired fasting glucose (IFG), 44.9% normal fasting glucose (NFG), while 2% had no FBG available. FBG categories were similarly distributed in the 71 patients without confirmed COVID-19 pneumonia. During follow up (median time 6 month) FBG was available for 321 out of the 453 (70.9%) surviving patients and showed a trend to a marginal increase [from 97 (87–116) to 100 (92–114) mg/dL; p = 0.071]. Transitions between FBG categories was analysed in subjects without pre-existing diabetes (265 out of 321). We identified three groups: i) patients who maintained or improved FBG during follow-up [Group A, n = 185; from 100 (86–109) to 94 (88–99) mg/dL; p < 0.001]; ii) patients who moved from the NFG to IFG category [Group B, n = 66: from 89 (85–96) to 106 (102–113) mg/dl; p < 0.001]; iii) patients who maintained or reached DFG during follow-up [Group C, n = 14: from 114 (94–138) to 134 (126–143) mg/dl; p = 0.035]. Male sex and ICU admission during the hospitalization were more prevalent in Group C compared to Group A or B. Conclusions. Six months after the SARS-CoV-2 infection DFG was evident in only few patients who experienced severe COVID-19 pneumonia.
Escherichia Coli Isolate From Hospital Sewage Is Carrying blaNDM-1 and blaoxa-10
Authors: Hu Zimeng , Chen Weiye , Guo Genglin , Dong Chen , Shen Yun , Qin Si , Chen Long , Zhang Wei
Published: April 2021

Carbapenems, as the “last line of defense” against gram-negative bacteria, are increasingly being challenged by drug-resistant bacteria, especially in Enterobacteriaceae. In this study, a carbapenems resistant gram-negative bacterium, named AH001, was isolated from hospital sewage, and modified Hoge test confirmed this bacterium can produce carbapenemase. Further analysis revealed that this bacterium is multi-drug resistance, which against additional seven antibiotics. Whole-genome sequencing and analysis showed that AH001 could not be classified by existing MLST, and its serotype couldn’t be distinguished among O9, O89 or O168 in O antigen prediction. More attention should be paid to the role of environmental source Escherichia coli in the development and transfer of drug resistance in the hospital environment.