bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigasi Pengambilan Keputusan Gen Y (Second Generation Existing Priority Members) untuk Menjadi Nasabah Prioritas BCA di Pekalongan (Sebuah Studi Fenomenologi)
Authors: Christianto Andreas Andy , Soesanto Harry
Published: January 2022

Gen Y, which is often referred to as Generation Millennials, will soon dominate the composition of the world of work and business in Indonesia. This millennial generation has a significant difference with previous generations, especially about what influences are the basis of their purchasing decisions. The researcher specifically examined how this millennial generation decided to join as a BCA Priority customer, what factors influenced their decision. The researcher used the Qualitative research method with a phenomenological narrative approach. The reason for choosing this method is so that researchers can interact directly with the speakers, dig deeper so that they get a more comprehensive picture of them. There were 8 speakers in this study which were divided into 4 groups, namely 1. Parents and Children of Priority customers, 2. Parents of Priority customers, Children not Priority customers, 3. Parents not BCA customers, Priority customer Children,4. Parents and Children are not Priority customers, but are included in the Priority criteria.            The results of this study indicate that millennial generation purchasing decisions are influenced by many factors that can be grouped into 2 things: factors that have been experienced, felt and fulfilled their needs, namely ease of transactions, privileges, special prices, business networks, and pride and other factors that are expectations what they want when they become priority customers, namely financial solutions and increasing their knowledge.            The new finding in this study was that parents' factors turned out to play a very important role for Gen Y especially the second generation of priority customers to decide to become BCA Prioritas customers.
Pengaruh Promosi, Motivasi, Gaya Hidup, Personal Selling Terhadap Minat Menggunakan Kartu Kredit
Authors: Sunanda Sunanda , Mirza Mirza
Published: January 2022

Tujuan dari penelitian ini adalah untuk mengetahui faktor faktor apa saja yang mempengaruhi minat seseorang untuk menggunakan kartu kredit. Proses pengumpulan data dilakukan dengan menyebar quisioner kepada 240 orang pengguna kartu kredit diluar Bank Mega di Jabodetabek. Hasil quisioner di analisis dan diolah menggunakan SPSS 25.0. Hasil analisis menunjukan variabel Motivasi memiliki pengaruh paling besar terhadap minat menggunakan kartu kredit, adapun besar pengaruhnya sebesar 33,7%, disusul variabel personal selling yang memiliki pengaruh terhadap minat menggunakan kartu kredit sebesar 11,4%, sedangkan untuk variabel promosi memiliki pengaruh terhadap minat menggunakan kartu kredit sebesar 10,1%, namun untuk varibel gaya hidup tidak memiliki pengaruh secara signifikan terhadap minat menggunakan kartu kredit dikarenakan hanya memiliki pengaruh 1,3%. Hasil analisis akan sangat berguna bagi manajemen Bank Mega dalam hal membuat kebijakan dan strategi untuk meningkatkan jumlah minat calon debitur untuk menggunakan kartu kredit Bank Mega.
Peningkatan Brand Satisfaction dan Brand Trust Berbasis Brand Value Terhadap Brand Loyalty (Studi Pada Pengguna Apple Iphone di Semarang)
Authors: Christyawan Harry , Sukresna I Made
Published: January 2022

Penelitian ini bertujuan untuk menganalisis faktor-faktor yang mempengaruhi loyalitas merek pada konsumen pengguna iPhone yang berdomisili di Semarang , dengan menggunakan variabel nilai merek, kepuasan merek , kepercayaan merek, dan loyalitas merek diharapkan dapat menjadi strategi bagi perusahaan untuk mendapatkan loyalitas pelanggan. Analisis data pada penelitian ini menggunakan pendekatan kuantitatif dengan metode analisis model persamaan struktural (SEM) dengan menggunakan software AMOS pada 159 klien yang telah ditentukan untuk menjadi responden penelitian melalui teknik non probability sampling. Penelitian ini terdiri dari enam hipotesis yang diajukan, hasil penelitian membuktikan bahwa ke enam hipotesis semua diterima dan terbukti memiliki pengaruh yang positif yang signifikan terhadap hubungan: 1) brand value dengan brand satisfaction, 2) brand value dengan brand trust, 3) brand satisfaction dengan brand trust, 4) brand value dengan brand loyalty 5) brand satisfaction dengan brand loyalty dan 6) brand trust dengan brand loyalty. Hasil penelitian ini diharapkan dapat memberikan masukan untuk perusahaan guna menyusun strategi untuk mendapatkan loyalitas dari perlanggan.
Perpindahan Merek (Brand Swithcing Behavior) Pada Air Minum Dalam Kemasan di Kota Pontianak
Authors: Lestari Mar'ah , Kurniari Dewi , Fitrianti Wanti
Published: January 2022

The behavior of the displacement of the brand often happens in causes consumer dissatisfaction of the product, thus giving the brand image of the bad against the company's products. At the time the level of consumer involvement is low, consumers will tend to switch brands, looking for other brands out of the market and this situation puts the consumer in an effort to find other variations. Research objectives Analyze the factors that cause the behavior of the displacement of the brand (Brand Switching Behavior) on the purchase of bottled water in the City of Pontianak, on the 150 respondents were selected purposively. Data analysis using Structural Equation Modeling (SEM). The results showed that on the factor of price and product attributes have a positive influence or significant effect on the behavior of the displacement of the brands of bottled water in the City of Pontianak. A positive effect is shown by the Price because Price is an important part in marketing strategy and is considered a consumer in terms of basic needs such as food and drink. The influence of the highest on the indicator of the price of the product with the indicator of the price of the product cheaper and diversification the price of diverse products, where the products with have the ability to compete in the price is a complete make consumers increasingly choose or consume the product, and the product attribute has significant effect with an indicator label and seal packaging that is attractive and safe, product color crystal clear and clean, and taste better on the tongue.
Perilaku Konsumen Gula Putih Bermerek dan Tidak Bermerek di Kabupaten Jember
Authors: Safira Maulida Rachma , Aji Joni Murti Mulyo
Published: January 2022

The purpose of this study was to determine the factors that influence consumer decisions in buying branded and unbranded white sugar, to determine the level of consumer satisfaction with branded and unbranded white sugar and to determine the factors that influence the level of consumer satisfaction with branded and unbranded white sugar in Jember Regency. This research was conducted using 200 respondents. The analysis tools used are logistic regression analysis, CSI analysis (Customer Satisfaction Index) and factor analysis. The results showed that the factors that significantly influence consumer decisions in buying branded and unbranded white sugar are income and number of family members. The CSI measurement results show that the consumer satisfaction index of unbranded and unbranded white sugar is in the fulfilled criteria, with a CSI value of 74.48% for branded and 70.30% for unbranded sugar. The results of the factor analysis show that there are three new factors related to the satisfaction level of consumers of branded and unbranded white sugar, namely the money value factor (product cleanliness and sugar prices), availability considerations factor (house distance, the ease of obtaining sugar, advertising, information from friends and information from family), and brand attribute factor (brand, color, packaging design and packaging weight).
Analysis Digital Customer Satisfaction in Online Purchase
Authors: Rezeki Sry , Muliauwan Shelly Christiana
Published: January 2022

In this digital era, everything has switched to an online system, starting from shopping, vehicles, ordering food, everything can be done online, everything can be obtained easily, just install an application to support online activities, we can meet all our needs, with the sophistication of technology, of course it makes it easier for us at all times. We can take activities for example when we buy clothes online, it certainly makes it easier for us from going to the market or mall to get clothes, now we just have to sit at home, open the application and clothes or orders will arrive directly at the door This study was conducted to test the level of customer satisfaction in making online purchases where the researchers made direct observations by monitoring the ratings given by customers on the online shopping site that is widely used by the public, namely Shoppe. The research method used is a qualitative descriptive method in which data is obtained directly through interviews with shopee users and observing assessments given by customers in the shopee application. The results obtained from this study are that many people feel satisfied after shopping online because they consider online shopping can save time, effort and get cheaper prices than traditional markets.
The Effect of Product Innovation, Value Co-Creation on Marketing Performance of a SMEs in Covid-19 Pandemic Era
Authors: Rahmawati Fauziyah , Novani Santi
Published: January 2022

This study aims to analyze product innovation and value co-creation on marketing performance in this pandemic covid-19. SMEs of food and beverage used as a sample. Sampling was done using a purposive sampling technique. Data were collected using a self-administered questionnaire. This study uses 34 data from MSMEs in the food and beverage sector affected by COVID-19. Partial Least Square (PLS) on Structural Equation Modeling (SEM) was chosen as the research method in this study. The results show that value co-creation have a significant effect on marketing performance. Product innovation negatively and not significant effects on marketing performance, and value co-creation significantly affect product innovation. The novelty in this study is a phenomenon that occurs; that is when the Covid-19 pandemic spreads in Indonesia. This study's limitation is needed to add other variables beyond the variables already in the model. This study only focused on SMEs for the food and beverage sector
Systematic Literature Review: Peran Media Sosial Instagram Terhadap Perkembangan Digital Marketing
Authors: Watajdid Nurul Islah , Lathifah Ari , Andini Dewi Syifa , Fitroh Fitroh
Published: January 2022

Masalah utama dalam komunikasi pemasaran adalah saluran komunikasi yang dapat digunakan dalam program pemasaran. Tujuan penelitian ini adalah untuk menjawab pertanyaan tentang bagaimana peran media sosial Instagram terhadap perkembangan pemasaran digital. Penelitian ini menerapkan metode Systematic Literature Review. Berdasarkan hasil tinjauan literatur sistematis, Peneliti menemukan 136 artikel Scopus dalam pencarian menggunakan Publish or Perish dan bantuan aplikasi lain seperti Zotero, Mendeley, VOSViewer, dan Microsoft Excel yang kemudian disaring menjadi 55 artikel terpilih untuk dianalisis secara deskriptif. Temuan menunjukkan bahwa media sosial Instagram telah berkontribusi terhadap perkembangan pemasaran digital. Media sosial Instagram telah berperan menjadi media komunikasi pemasaran, meningkatkan kesadaran merek (brand awareness) mempengaruhi keterlibatan dan tingkah laku konsumen, dan menghasilkan data yang mendukung strategi pemasaran.
Adaptación de la escala Dragones de Inacción Barreras Psicológicas (DIPB) en población colombiana
Authors: Alfonso Gutiérrez Laura Sofía , Prieto Patiño Luis Enrique
Published: January 2022

El daño ambiental que se ha venido provocando a causa de la actividad humana es preocupante, razón por la cual se ha identificado como una de las posibles soluciones tener un comportamiento proambiental. Sin embargo, se ha visto que hay barreras psicológicas que impiden o dificultan esta conducta. Por este motivo, con el fin de tener un instrumento que permita evaluar estas barreras psicológicas en nuestro contexto, el objetivo de la presente investigación fue realizar la adaptación de la escala Dragons of Inaction Psychological Barriers (dipb) en población colombiana. La muestra estuvo compuesta por 810 estudiantes universitarios de Bogotá y Chía, Colombia; 367 hombres y 443 mujeres con edades entre los 15 y los 48 años (M = 19.67, DE = 2.414). En general, se realizó un análisis factorial exploratorio y un análisis factorial confirmatorio, con los cuales se comprobó la existencia de una estructura de cinco factores con 20 ítems; se realizaron análisis de reactivos y fiabilidad que demostraron que el instrumento tiene una alta consistencia interna; y se llevaron a cabo dos estudios de invarianza, con los que se demostró que la estructura factorial es invariante para todos los grupos de estudio. Además, se realizó la baremación del instrumento total. En conclusión, esta adaptación del dipb presenta adecuada validez y fiabilidad, y permite guiar futuras investigaciones acerca de las barreras de inacción en el contexto latinoamericano, a la vez que aporta un insumo para realizar un primer diagnóstico de este constructo en Colombia.
High Wisdom Intelligence- Discussing Education of High Wisdom Intelligence
Authors: Ma Wen , Zhu Yanqin , Li Chunli , Zhang Bo , Tian Xin
Published: January 2022

The number of talented persons who are equipped with high wisdom intelligence will immediately determine the quality of humankind’s entire life, and the future trend for humankind’s innovation and creation in fields such as thinking, cognition, society, politics, economy, military, science, arts, culture, and so on. Meanwhile, it protects the harmonious development of various fields. By illustrating the meanings of applying high wisdom intelligence in the survival and prosperity for each nation, ethnicity and individual, this article has a significant application to the understanding of educational studies of highwisdom intelligence.
A Smartphone-based Plant Disease Detection and Treatment Recommendation System using Machine Learning Techniques
Authors: Isinkaye Folasade
Published: January 2022

Plant diseases cause major crop production losses worldwide, and a lot of significant research effort has been directed toward making plant disease identification and treatment procedures more effective. It would be of great benefit to farmers to be able to utilize the current technology in order to leverage the challenges facing agricultural production and hence improve crop production and operation profitability. In this work, we designed and implemented a user-friendly smartphone-based plant disease detection and treatment recommendation system using machine learning (ML) techniques. CNN was used for feature extraction while the ANN and KNN were used to classify the plant diseases; a content-based filtering recommendation algorithm was used to suggest relevant treatments for the detected plant diseases after classification. The result of the implementation shows that the system correctly detected and recommended treatment for plant diseases
Between negation and engagement. European integration in Mieczysław F. Rakowski’s journalism and political activity in 1958–1990
Authors: Barabasz Adam
Published: January 2022

The main aim of the article was to present the views of Mieczysław F. Rakowski on the multifaceted process of European integration in the years 1958–1990. Attention was focused on the “German problem”, the ideological war: capitalism – communism, the enlargement of the European Communities to new countries in the 1970s and 1980s.
Enhancement of safety communication model
Authors: Schiller Frank , Judd Dan , Supavatanakul Peerasan , Hardt Tina , Wieczorek Felix
Published: January 2022

A fundamental measure of safety communication is the residual error probability, i. e., the probability of undetected errors. For the detection of data errors, typically a Cyclic Redundancy Check (CRC) is applied, and the resulting residual error probability is determined based on the Binary Symmetric Channel (BSC) model. The use of this model had been questioned since several error types cannot be sufficiently described. Especially the increasing introduction of security algorithms into underlying communication layers requires a more adequate channel model. This paper introduces an enhanced model that extends the list of considered data error types by combining the BSC model with a Uniformly Distributed Segments (UDS) model. Although models beyond BSC are applied, the hitherto method of the calculation of the residual error probability can be maintained.
Stemmatologisches
Authors: Ziffer Giorgio
Published: January 2022

This is the publication of a brief unknown text of one page, written by Paul Maas in October 1935, in which the very first definition and analysis of ‘separative’ and ‘conjunctive errors’ are given. What we have before us is in fact the germ of the seminal essay Leitfehler und stemmatische Typen which Maas published two years later in the “Byzantinische Zeitschrift”.
Digital Gender Divide and Convergence in the European Union Countries
Authors: López-Martínez María , García-Luque Olga , Rodríguez-Pasquín Myriam
Published: January 2022

The aim of this study is to examine the digital gender divide in the European Union (EU) countries by applying two widely used indicators: percentage of the population who has used the Internet in the last 3 months (ICT-USE indicator) and percentage of the population who has made an online purchase in the last 3 months (ICT-PURCHASE indicator). With these indicators, the digital gender gaps are shown in absolute and relative terms. In addition, the European convergence beta and sigma, between the years 2007 and 2019, is also analyzed. The results among European countries show that the ICT-USE indicator has a lower dispersion than the ICT-PURCHASE indicator; hence, in general, the digital gender divide or gap is usually lower when ICT-USE is used in comparison with ICT-PURCHASE. The highest values of the digital gender gap in the EU, regardless of the indicator used, are found in Croatia and Italy, reflecting an unfavorable position for women. Ireland is also in this group, but in its case, the results show an unfavorable position for men. Additionally, Cyprus does not register gender differences in either of the two indicators analyzed. Finally, the convergence between European countries is corroborated, both in the indicators analyzed and in the different gender digital gaps built.
Numerical study of the energy efficiency of the building envelope containing multi-alveolar structures under Tunisian weather conditions
Authors: Lajimi Nour , Ben Taher Nour , Boukadida Noureddine
Published: January 2022

The study of the thermal inertia of buildings is a subject of major interest. The thermal insulation and the nature of the wall sensitively modify the inertia of the building and are the solutions to improve the energy efficiency of the envelope. The roof is well exposed to solar radiation in summer and contributes to significant losses in winter due to convective exchanges. To lead to a thermal comfort, a thermal insulation is necessary. In this context, we carry out a numerical study of the thermal behavior of a building with two zones in variable meteorological conditions for a Tunisian climate (region of Sousse) based on the thermoelectric analogy and using the nodal method as a numerical method. The object of this work is to study the effect of the thermal inertia of the roof equipped with a multi-alveolar structure on the thermal behavior of the air inside the room and on its energy consumption. Taking into account the energy input of occupant, a complete model was established to increase the accuracy of the calculations. The results show that the multi-alveolar structure placed on the outside of the roof reduces energy consumption during the winter period when the alveolar structure is placed in the conductive direction and during the summer period when the alveolar structure is placed in the insulate direction.
Truth in Pastoral Practice: A Firmer Foundation for Contested Territory
Authors: Lasair Simon
Published: January 2022

Truth in the West is highly contested. The advent of post-truth politics, in addition to the ongoing culture wars, mitigates against truth being understood solely on the basis of objective facts, as it was in the past. For pastoral carers and counsellors, this raises significant questions: how to build shared understandings of truth between individuals and in communities? This article proposes a solution in an incarnational approach to pastoral work. Drawing upon the work of Rowan Williams, Raimon Panikkar, Diarmuid O’Murchu, and St. Maximos the Confessor, this article offers both theological and practical considerations regarding this approach.
When the “Ostjuden” Returned: Linguistic Continuities in German-Language Writing about Eastern European Jews
Authors: Kałczewiak Mariusz
Published: January 2022

This article examines the dynamics that allowed the derogatory term “Ostjuden” to reappear in academic writing in post-Holocaust Germany. This article focuses on the period between 1980’s and 2000’s, complementing earlier studies that focused on the emergence of the term “Ostjuden” and on the complex representations of Eastern European Jews in Imperial and later Weimar Germany. It shows that, despite its well-evidenced discriminatory history, the term “Ostjuden” re-appeared in the scholarly writing in German and has also found its way into German-speaking public history and journalism. This article calls for applying the adjectival term “osteuropäische Juden” (Eastern European Jews), using a term that neither essentializes Eastern European Jews nor presents them in an oversimplified and uniform manner.
Lawsone (2-hydroxy-1,4-naphthaquinone) derived anticancer agents
Authors: Singh Arvind , Basu Amartya , Sharma Aditi , Priya Anu , Kaur Manmmet , Kaur Gurpreet , Banerjee Bubun
Published: January 2022

2-Hydroxy-1,4-naphthaquinone, commonly known as lawsone, represents an extremely important biologically active naturally occurring compound. It can easily be isolated from Lawsonia inermis (henna) tree leaf extract. Last decade has seen tremendous applications of lawsone as a starting component for the preparation of various organic scaffolds. Many of these synthesized scaffolds showed a wide range of biological activities including potential activities towards several cancer cell lines. This review deals with diverse synthetic methods of lawsone derived scaffolds and their screening against different anti-cancer cell lines along with promising results.
Passive Proprioceptive Training Alters the Sensitivity of Muscle Spindles to Imposed Movements
Authors: Ackerley Rochelle , Samain-Aupic Léonard , Ribot-Ciscar Edith
Published: January 2022

Humans rely on precise proprioceptive feedback from our muscles, which is important in both the acquisition and execution of movements, to perform daily activities. Somatosensory input from the body shapes motor learning through central processes, as demonstrated for tasks using the arm, under active (self-generated) and passive conditions. Presently, we investigated whether passive movement training of the ankle increased proprioceptive acuity (psychophysical experiment) and whether it changed the peripheral proprioceptive afferent signal (microneurography experiment). In the psychophysical experiment, the ankle of 32 healthy human participants was moved passively using pairs of ramp-and-hold movements in different directions. In a pretraining test, participants made judgements about the movement direction in a two-alternative forced choice paradigm. Participants then underwent passive movement training, but only half were cued for learning, where a reference position was signaled by a sound and the participant had to learn to recognize this position; they then completed a post-training test. In a paradigm using the same setup, nine healthy participants underwent microneurography recordings of Ia muscle afferents from the peroneal nerve, where all were cued during training. In the psychophysical experiment, proprioceptive acuity improved with training only in the cued group. In the microneurography experiment, we found that muscle afferent firing was modulated, via an increase in the dynamic index, after training. We suggest that changes in muscle afferent input from the periphery can contribute to and support central perceptual and motor learning, as shown under passive conditions using ankle movements, which may be exploited for movement rehabilitation.
Excitable Axonal Domains Adapt to Sensory Deprivation in the Olfactory System
Authors: George Nicholas M. , Gentile Polese Arianna , Merle Laetitia , Macklin Wendy B. , Restrepo Diego
Published: January 2022

The axon initial segment (AIS), nodes of Ranvier, and the oligodendrocyte-derived myelin sheath have significant influence on the firing patterns of neurons and the faithful, coordinated transmission of action potentials (APs) to downstream brain regions. In the olfactory bulb (OB), olfactory discrimination tasks lead to adaptive changes in cell firing patterns, and the output signals must reliably travel large distances to other brain regions along highly myelinated tracts. Whether myelinated axons adapt to facilitate olfactory sensory processing is unknown. Here, we investigate the morphology and physiology of mitral cell (MC) axons in the olfactory system of adult male and female mice and show that unilateral sensory deprivation causes system-wide adaptations in axonal morphology and myelin thickness. MC spiking patterns and APs also adapted to sensory deprivation. Strikingly, myelination and MC physiology were altered on both the deprived and nondeprived sides, indicating system level adaptations to reduced sensory input. Our work demonstrates a previously unstudied mechanism of plasticity in the olfactory system.

SIGNIFICANCE STATEMENTSuccessful transmission of information from the olfactory bulb (OB) to piriform cortex through the lateral olfactory tract (LOT) relies on synchronized arrival of action potentials (APs). The coincident arrival of APs is dependent on reliable generation of APs in the axon initial segment (AIS) and fast conduction mediated by axon myelination. Here, we studied changes in mitral cell (MC) firing and AIS structure as well as changes in myelination of the LOT on unilateral olfactory deprivation in the adult mouse. Strikingly, myelination and MC physiology were altered on both the deprived and nondeprived sides, indicating system level adaptations to reduced sensory input. Our work demonstrates a previously unstudied mechanism of plasticity in the olfactory system.
LESSONS LEARNED FROM REMOTE EDUCATION
Authors: Šimková Květoslava , Ramadanová Jitka
Published: January 2022

This paper focuses on some aspects of remote education that can be implemented in face-to-face classes in order to improve and enhance the teaching/learning process. The authors present the results of the questionnaire survey conducted among the teachers of the Institute of Applied Language Studies of the University of West Bohemia in Pilsen (hereinafter referred to as ‘UWB’) and also among the students of the Faculty of Economics at the same university in the spring term of 2021, evaluating two semesters of remote education. Having analyzed the results of the questionnaires, the authors of the paper aim to share their experience and introduce the best practice that the Business English (hereinafter referred to as ‘BE’) teachers at the UWB have decided to apply to their future BE courses.
„Trzy nierówne połówki” odrodzonej Polski, czyli pierwsze miesiące niepodległości w świetle współczesnych podręczników do nauczania historii w szkołach ponadpodstawowych i ponadgimnazjalnych
Authors: Białokur Marek
Published: January 2022

The presented article is an attempt to show the challenges Poland faced just after regaining independence in 1918. The source of the article are school history textbooks published at the end of the 20th and the beginning of the 21st century. These types of studies are among the most popular and most important history books, which is determined by their nature and audience.
Слова-бленды в газетных заголовках
Authors: Miturska-Bojanowska Jolanta
Published: January 2022

In modern Russian, word blends can be found in fiction, journalism, advertising, as well as in scientific terminology and in everyday language. This study presents the press titles of the daily “Коммерсанть” (from 2020 and 40 issues from 2021; online version) in which lexical blends were used. Structural analysis shows that the dominant role in their construction is played by haplologic blends and blends based on tmesis (“matryoshka” words and quasi-tmesis words). An interesting procedure is the simultaneous transformation of precedent texts (substitution) and the use of word blends. Noun derivatives are most frequently represented in the entire illustrative material. Next to them we also find adjective, verb and adverb blends.
Lack of ZnT8 protects pancreatic islets from hypoxia- and cytokine-induced cell death
Authors: Karsai Maria , Zuellig Richard A , Lehmann Roger , Cuozzo Federica , Nasteska Daniela , Luca Edlira , Hantel Constanze , Hodson David J , Spinas Giatgen A , Rutter Guy A , Gerber Philipp A
Published: January 2022

Pancreatic β-cells depend on the well-balanced regulation of cytosolic zinc concentrations, providing sufficient zinc ions for the processing and storage of insulin, but avoiding toxic effects. The zinc transporter ZnT8, encoded by SLC30A8,is a key player regarding islet cell zinc homeostasis, and polymorphisms in this gene are associated with altered type 2 diabetes susceptibility in man. The objective of this study was to investigate the role of ZnT8 and zinc in situations of cellular stress as hypoxia or inflammation. Isolated islets of WT and global ZnT8−/− mice were exposed to hypoxia or cytokines and cell death was measured. To explore the role of changing intracellular Zn2+ concentrations, WT islets were exposed to different zinc concentrations using zinc chloride or the zinc chelator N,N,N′,N′-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine (TPEN). Hypoxia or cytokine (TNF-α, IFN-γ, IL1-β) treatment induced islet cell death, but to a lesser extent in islets from ZnT8−/− mice, which were shown to have a reduced zinc content. Similarly, chelation of zinc with TPEN reduced cell death in WT islets treated with hypoxia or cytokines, whereas increased zinc concentrations aggravated the effects of these stressors. This study demonstrates a reduced rate of cell death in islets from ZnT8−/− mice as compared to WT islets when exposed to two distinct cellular stressors, hypoxia or cytotoxic cytokines. This protection from cell death is, in part, mediated by a reduced zinc content in islet cells of ZnT8−/− mice. These findings may be relevant for altered diabetes burden in carriers of risk SLC30A8 alleles in man.
Violencia en confinamiento: metáforas obsesivas en las obras de Amparo Dávila y Leonora Carrington
Authors: Luna Chávez Marisol
Published: January 2022

En las obras de Amparo Dávila y Leonora Carrington existe la presencia de elementos que se repiten de manera sistemática, obsesiva, lo cual aporta a la poética de ambas autoras un estilo particular. Una circunstancia crucial que se manifiesta insistentemente en su narrativa es la recreación de espacios de confinamiento en donde el o la protagonista experimenta extrema violencia física o psicológica. Para Dávila, un aspecto reiterativo es la vulnerabilidad padecida por sus personajes al convertirse en las víctimas de su entorno vital. En contraste, para Carrington, la crueldad del encierro se establece de manera institucionalizada. En ambas autoras, el orden doméstico autoimpuesto o la violencia caótica infligida produce seres o situaciones sobrenaturales o extrañas. Identificar los tipos de violencia en lugares de reclusión y las metáforas obsesivas que esta produce, a través de la psicocrítica de Mauron, es el objetivo de este artículo.
Dosymmetric estimates of 99mTc (MAA) and 133Xe in newborn lungs using Cristy-Eckerman / Segars representations
Authors: Vasquez-Arteaga Marcial , Vega-Carrillo Héctor , Montalvo-Soberon Gustavo , Rivera-Vásquez Juan , Jaramillo-Arica Pedro , Vasquez-Silva Marcela , Cabrera-Salvatierra Carlos , Rojas-Alegría Roberto
Published: January 2022

Using the Cristy-Eckerman (C-E) / Segars anatomical representations and the MIRD formalism, the Absorbed doses in lungs of newborn patients scanned with radiopharmaceuticals 133Xe (ventilation) and 99mTc (MAA) (perfusion) are estimated. These representations are phantoms used in Monte Carlo calculations to determine specific absorbed fractions, which, associated with the pharmaceutical residence time, determine the absorbed dose. Concerns about the dosimetric impact of using these ventilation / perfusion agents, as well as the use of different phantoms, were explored in newborn patients. When the lungs were scanned with 99mTc (MAA), the relative difference in total dose between the C-E / Segars anatomical representations was 1.0%. When the lungs were scanned with 133Xe, the relative difference in total dose between the anthropomorphic representations of C-E / Segars was 0.5%. Regardless of the radiopharmaceutical used for the pulmonary studies of a newborn patient, the substitution of the C-E representation for that of Segars does not reflect very significant changes in the calculation of the absorbed dose in the lungs, where the greatest dosimetric contribution is its self-dose, which is supplied mainly by the electrons produced during the 99mTc and 133Xe decay.
Gestión de riesgo para la prevención primaria de tuberculosis en una entidad administradora de planes de beneficios en salud en Colombia
Authors: Rojas Suárez Marlen Astrid , García Ubaque Juan Carlos
Published: January 2022

Objetivo Diseñar y validar un modelo para la gestión del riesgo en salud, orientado a disminuir la incidencia de la tuberculosis en la población afiliada a las empresas administradoras de planes de beneficios colombianas (EAPB) desde la perspectiva de prevención primaria de la enfermedad. Métodos A partir de una reflexión inductiva, se diseñó un modelo de atención en tuberculosis orientado a coordinar acciones de gestión integral de riesgo en salud en el contexto de un modelo de aseguramiento fundamentado en la atención primaria en salud (APS). Se realizó una validación facial y de contenido del modelo con expertos temáticos en el programa de control de la tuberculosis de algunas EAPB y otros sectores. Resultados Se identificaron aspectos eje, fortalezas y oportunidades de mejora que se utilizaron como elementos centrales para el modelo, el cual se orienta a prevenir el desarrollo de la enfermedad, al tiempo que continúa promoviendo el seguimiento a los tratamientos y los procesos de rehabilitación. La revisión de expertos permitió validar y enriquecer el diseño planteado. Discusión La gestión del riesgo en salud es una responsabilidad asignada dentro del sistema de salud colombiano a las EAPB. El diseño del presente modelo aporta para que la gestión del riesgo se realice de manera organizada, definida y estandarizada, a fin de obtener mejores resultados en la prevención de la tuberculosis.
Letermovir profilaxis allogén vérképző-őssejt transzplantációban: egy hazai centrum gyakorlati tapasztalatai
Authors: Sinkó János , Körösmezey Gábor , Paksi Melinda , Gopcsa László , Reményi Péter
Published: January 2022

Összefoglaló.
Bevezetés: A humán cytomegalovírus infekció direkt és indirekt
szövődményei napjainkban is veszélyeztetik az allogén őssejt-transzplantációval
kezelt betegeket. A széles körben alkalmazott preemptív stratégia mellett
előnyös lehet a kórokozó reaktivációjának megelőzése profilaktikusan adagolt
vírusellenes vegyülettel. A letermovir innovatív hatásmechanizmusú, szűk
spektrumú antivirális szer, mely allogén őssejt-transzplantáltak körében
végzett, placebo kontrollált klinikai vizsgálatban csökkentette a
cytomegalovírus infekciók gyakoriságát és javította a túlélést. A szerzők 23,
allogén őssejt-transzplantált beteg retrospektív módon gyűjtött adatait
ismertetik, akik a beavatkozás kapcsán letermovir profilaxisban részesültek. A
betegek több mint fele akut leukémiában szenvedett, harmaduk aktív betegséggel
került transzplantációra, kétharmaduk donora haploidentikus egyezést mutatott. A
letermovir adagolása során 2, azt követően további 3 személyben lépett fel
cytomegalovírus infekció. Szervi érintettséggel járó cytomegalovírus betegség
egyetlen esetben sem alakult ki. A megfigyelési időszak során 2 fő hunyt el,
cytomegalovírustól független okok miatt. Az alkalmazhatóságot korlátozó
mellékhatást nem észleltek. A letermovir a mindennapi klinikai gyakorlatban is
hatékonynak és biztonságosnak bizonyult az őssejt-transzplantáltak
cytomegalovírus fertőzésének megelőzésére.

Summary.
Introduction: Direct and indirect effects of cytomegalovirus
infection remain an ongoing threat to patients treated with allogeneic stem cell
transplantation. In addition to the widely used preemptive approach, prevention
of viral replication with a prophylactically administered antiviral drug seems
to be feasible. Letermovir, a narrow-spectrum antiviral compound with an
innovative mechanism of action, has been shown to decrease the incidence of
cytomegalovirus infection and to improve survival in a placebo-controlled
clinical trial recruiting allogeneic stem cell transplant patients. Authors
present retrospectively collected data from 23 patients receiving letermovir
prophylaxis as a part of their allogeneic stem cell transplantation procedure.
More than half of prophylaxed individuals had acute leukemia, a third of them
underwent transplantation with an active disease and two third of the cohort had
a haploidentical donor. During prophylaxis 2, subsequently further 3 patients
developed a cytomegalovirus infection. No organ-specific disease could be
detected. Through the observational period 2 patients have died due to causes
unrelated to cytomegalovirus. No side effect interfering with drug use could be
revealed. In this real-life case series letermovir has been shown to be
effective and safe for the prevention of cytomegalovirus infection in allogeneic
stem cell transplant patients.
SOCIAL DEIXIS ANALYSIS IN THE FINAL INTERVIEW WITH THE OBAMAS
Authors: Nuryusticia Erfina , Nurrachman Dian
Published: January 2022

The final interview with Obama, as one of influential persons in the world, attracted many media to broadcast. His interview showed real-life interaction of a representative figure so that the way he used language is also representative. Specifically, this study aims at finding out the kinds of social deixis and to describe the function of social deixis in The Final Interview with the Obamas. The data are analyzed in a qualitative descriptive method to point out the phenomena of social deixis in the news as a part of daily life and since the collection of the data are mostly analyzed by using description and explanation form which focus on the characteristics, types, and the reason why the usage of social deixis is the main issues to be investigated. Based on the analysis of The Final Interview with The Obamas from the PeopleTV YouTube channel, it can be concluded that all types of social deixis according to Levinson’s theory are found in the object of research. There are relational which manifested by the speaker and referent, the speaker and addressee, the speaker and bystander, and the speaker and setting. There is also absolute social deixis which is manifested by the authorized speaker, and the authorized recipient absolute social deixis. In addition, the three functions of social deixis are also found in the utterances in The Final Interview with The Obamas. Those are the social status differentiation function, politeness function, and social identity function. Keywords: Social Deixis; Interview; Pragmatics
DIRECTIVE ACTS IN ONWARD FILM BY DAN SCANLON
Authors: Kumala Zuhrotunnisa Elviana Indah , Rohmah Zuliati
Published: January 2022

This study aims to describe the types of directive acts contained in the Onward film using the theory of Keith Allan (1986). The subject of this study is the main characters of the Onward film by Dan Scanlon. This qualitative-descriptive study collected data from the main characters’ utterances of the film in the form of words, phrases, or sentences that contain directive acts in each scene of the Onward film. The researchers collected data by listening, recording, and note-taking to obtain complete and reliable data on various forms of directive acts. The researchers as the main instruments analyzed the data in four stages: identification, classification, interpretation, and conclusion. The results of the analysis of 51 directive acts show six kinds of directive acts, that is, advice, requirements, permissions, prohibitions, questions, and requests with questions as the most dominant ones.
KAJIAN POTENSI WILAYAH PERIKANAN DENGAN PENDEKATAN PRA DI KECAMATAN JUNJUANG SIRIH KABUPATEN SOLOK PROVINSI SUMATERA BARAT
Authors: Aini Sarifah , Hanan Abdul , Yuniarti Tatty , Putra Angkasa , Nurlaela Eli , Hamdani Hamdani , Sudino Dinno
Published: January 2022

Kabupaten Solok memiliki potensi perikanan yang mumpuni dalam bidang penangkapan, budidaya dan pengolahan. Potensi perikanan dapat dikembangkan dengan cara meningkatkan peranan sumber daya manusia yang menjadi motor penggerak bagi aspek perikanan. Tujuan praktik keahlian adalah untuk mengidentifikasi potensi perikanan dan permasalahannya di Kecamatan Junjuang Sirih. Hasil identifikasi wilayah perikanan diharapkan dapat bermanfaat dijadikan acuan dalam menentukan kegiatan penyuluhan melalui aksi penyuluhan yang tepat. Praktik keahlian dilaksanakan pada tanggal 1 sampai dengan 30 Oktober 2019. Metode penelitian menggunakan Participatory Rural Appraisal (PRA) yang melibatkan masyarakat dalam merumuskan permasalahan. Penentuan jumlah responden diperoleh dengan metode Snowball yaitu menemui tokoh masyarakat/ pamong desa, setelah itu diarahkan menemui pelaku utama dan anggota kelompok perikanan yang ada di desa sampel yang aktif sebagai responden. Didapatkan 15 responden. Data primer melaui melalui observasi dan wawancara langsung dengan kuesioner. Analisis data menggunakan analisis deskriptif kualitatif. Analisa permasalahan perikanan menggunakan metoda tree analisis. Hasil penelitian menunjukkan bahwa Kecamatan Junjuang Sirih memiliki potensi perikanan meliputi SDA berupa danau, kolam dan sawah minapadi. Sumber daya manausia perikanan meliputi pelaku usaha atau RTP sebanyak 194 orang yang tergabung dalam 14 kelompok perikanan. Bidang usaha kelompok perikanan meliputi penangkapan (80 orang), budidaya (63) dan pengolahan (51). Komoditas unggulan bidang penangkapan adalah ikan billih endemik. Poklahsar mengolah hasil penangkapan menjadi olahan ikan bilih goreng. Komoditas budiya adalah ikan nila dan ikan lele. Nilai R/C usaha bidang periakan tersebut rata-rata di atas 1. Sumber Daya Manusia yang memiliki usaha penangkapan sebanyak 70 orang. Bidang Budidaya Perikanan dengan potensi pembesaran ikan nila dan lele, Hasil analisa permasalah penangkapan yaitu belum menggunakan alat tangkap ramah lingkungan rantai selama penangkapan ikan. Permasalahan budidaya yaitu belum melakukan budidaya CBIB dan harga pakan komersial yang mahal. Bidang pengolahan belum menerpakan sanitasi dan higenitas. Produk olahan juga belum banyak dikonsimsi oleh anak-anak. Rekomendasi praktik akhir adalah perlunya penggunaan alat tangkap ramah lingkungan, perlunya membuat pakan alternative pengganti pakan komersial dan peningkatan sanitasi higienis serta status gizi anak-anak masih perlu untuk dirujuk kembali.
QUALITY AND MICROBIOLOGICAL SAFETY OF A DAILY MORTALITY COMPOST PRODUCED IN A VETERINARY FACULTY AT SÃO PAULO STATE
Authors: Villamizar Cancelado Sonia
Published: January 2022

Introduction: Daily and outbursts mortality composting have been identified as one of the finest methods for final disposal of animal corpses, but the probable threat of pathogens transmission truly limits its use. Materials and Methods:  In this study we evaluated the quality and microbiological biosafety of a compost produced in daily mortality experimental unit composting at the Universidade Estadual Paulista in the state of Sao Paulo, Brazil. Settled compost sample was evaluated in order to determine the presence and counting of coliforms and Salmonella sp. and the pathotypes of E. coli STEC, EPEC and EHEC using culture and molecular techniques.  The occurrence of frequent soil borne phytopathogenic fungi was also estimated using selective and differential microbiological culture media. Results and Discussion: The occurrence of pathogenic E. coli, Salmonella sp and phytopathogenic fungi were negative. Coliforms level was 3.05 log10/g. Concussions: The results showed that daily mortality composting method is effective to reduce pathogenic microorganisms, however, in order to add the product on crops or plants such as vegetables that are for direct human consumption, additional tests must be performed to assess the presence of viral pathogens and endospores forming bacteria.
Management of biobanking for medical genetics research
Authors: Tabakov V. Yu.
Published: January 2022

Biobanking is one of the most important elements of the modern infrastructure for biomedical research. Organization of a biobank on the basis of the N. P. Bochkov Medical Genetics Research Center provides a centralized infrastructure for preparing biomaterial for research. Biobank has the format of a research equipment sharing center and works with two types of unique biomaterials from patients with genetic diseases: blood/blood components and vital cells of various tissue origin. The storage facility of the Biobank is equipped with low-temperature (-80° C) and cryostorage (-196° C) systems. Identification and search of samples is carried out using a bar-coding system and is implemented through the information interface of the biobank, which is integrated into the general database of patients at the Medical Genetics Research Center. Information on biomaterial samples is presented in periodically updated catalogs on the page of equipment sharing center “Biobank”. Biobank collection is available to internal and external users.
Creation of a collection of blood samples of patients with multiple myeloma
Authors: Gnennaya N. V. , Timofeeva S. V. , Sitkovskaya A. O. , Novikova I. A. , Lysenko I. B. , Kamaeva I. A. , Kit O. I.
Published: January 2022

Aim. To create a collection of samples of blood components of patients with multiple myeloma for potential fundamental and applied biomedical research.

Material and methods. The material was collected according to the developed algorithm, including the collection of clinical information, biological material, sample preparation, quality control and storage in the biobank of the National Medical Research Center of Oncology.

Results. As of August 2021, the cryostorage of the National Medical Research Center of Oncology biobank contains a collection of 175 samples of blood serum, plasma and mononuclear cell fraction of patients with multiple myeloma. Samples were obtained from 32 patients of both sexes, the mean age of which was 59,5±1,65 years. To create an electronic catalog, personal, clinical and laboratory data about patients were collected, after which each sample was assigned its own unique identification number. Written informed consent was obtained from all patients for the storage of their biomaterial in a biobank with possible subsequent use for scientific purposes. Freezing of the obtained samples was carried out in accordance with low-temperature storage protocol. The electronic catalog contains a wide range of systematized clinical and laboratory information on samples.

Conclusion. The collection of multiple myeloma samples is a unique resource for potential research on its pathophysiology, the development of diagnostic biomarkers, and the search for targeted agents.