bluuebunny/crossref_metadata_2025 huggingface dataset:
The Who, Where, and What of the Highly Cited Papers in Sustainability from 2009 to 2023: A Bibliometric Analysis
Authors: Sheu Jen Jang , Lee Chang-Yen
Published: April 2023

This paper presents a bibliometric analysis of highly cited papers published in the journal Sustainability between 2009 and 2023. The aim is to identify influential countries, authors, and papers, as well as patterns in authorship and citation trends. The analysis focuses on frequently cited sources, the most cited research papers and references within the journal, and trends in author keywords. The analysis shows that Sustainability is a leading publication in sustainability research, with an annual growth rate of 53.57%. The selected papers, published between 2013 and 2022, have an average age of 2.11 years and an average of 88.12 citations each. The study highlights the most influential countries in sustainability research published in Sustainability, with China leading, followed by the United States and Germany. The most prolific authors are from China, Spain, and Italy. Interdisciplinary collaboration is essential to address complex sustainability challenges, as shown in the papers published in Sustainability. The study emphasizes the importance of staying informed about emerging trends and research directions in the field of sustainability published in this journal Sustainability. It underscores the significance of fostering international collaborations and partnerships to address complex sustainability challenges facing our world today, as evidenced by the papers published in Sustainability. Overall, this bibliometric analysis provides valuable insights into the current state of sustainability research published in Sustainability and its implications for policy and practice. It highlights key areas for future research and underscores the need for interdisciplinary collaboration to address complex sustainability challenges, as demonstrated by the papers published in Sustainability. These findings have important implications for policymakers, researchers, and practitioners interested in promoting sustainable development in the field of sustainability., as published in Sustainability.
TAO-DFT with the Polarizable Continuum Model
Authors: Seenithurai Sonai , Chai Jeng-Da
Published: April 2023

For the ground-state properties of gas-phase nanomolecules with multi-reference character, thermally-assisted-occupation density functional theory (TAO-DFT) has been recently found to outperform the widely used Kohn-Sham density functional theory, when the conventional exchange-correlation energy functionals are employed. Aiming to explore solvation effects on the ground-state properties of nanomolecules with multi-reference character at a minimal computational cost, we combine TAO-DFT with the polarizable continuum model (PCM). To show its usefulness, TAO-DFT-based PCM (TAO-PCM) is employed to study the electronic properties of linear acenes in three different solvents (toluene, chlorobenzene, and water). According to TAO-PCM, in the presence of these solvents, the smaller acenes should have nonradical nature, and the larger acenes should have increasing polyradical nature, showing remarkable similarities to the past findings in the gas phase.
Fuzzy Adaptive Parameter in the Dai-Liao Optimization Method Based on Neutrosophy
Authors: Stanimirović Predrag , Ivanov Branislav , Stanujkić Dragiša , Kazakovtsev Lev , Krutikov Vladimir , Karabasevic Darjan
Published: April 2023

The influence of neutrosophy in the previous period is constantly growing in many areas of science and technology. Moreover, various applications of the neutrosophic approach have become more common in recent years. Our goal in this research is to utilize the neutrosophy to improve the performance of the Dai-Liao conjugate gradient (CG) method. Specifically, in this research, we propose and investigate a new neutrosophic logic system to calculate the key parameter t involved in the Dai–Liao CG iterations. Theoretical analysis and numerical experience indicate that the efficiency and robustness of the new rule for determining t. Combining the neutrosophy and the Dai-Liao conjugate gradient method, we propose and explore a new Dai-Liao CG iterations for solving large-scale unconstrained optimization models. The global convergence is established under common assumptions and the backtracking line search. Finally, by conducting numerical experiments, computational evidence demonstrates that the new fuzzy neutrosophic Dai-Liao conjugate gradient method is computationally effective and robust.
Nutritional Aspects of Iron in Health and Disease
Authors: Charlebois Edouard , Pantopoulos Kostas
Published: April 2023

Dietary iron assimilation is critical for health and essential to prevent iron deficient states and related comorbidities, such as anemia. The bioavailability of iron is limited, while its absorption and metabolism are tightly controlled to keep body iron stores within a relatively narrow range. Genetic inactivation of the iron hormone hepcidin causes hereditary hemochromatosis, an endocrine disorder of iron overload characterized by chronic hyperabsorption of dietary iron, with deleterious clinical complications if untreated. The impact of high dietary iron intake and elevated body iron stores in the general population is not well understood. Herein, we summarize epidemiological data suggesting that high intake of heme iron, which is abundant in meat products, poses a risk factor for metabolic syndrome pathologies, cardiovascular diseases, and some cancers. We discuss clinical relevance and potential limitations of data from cohort studies, as well as the need to establish causality and elucidate molecular mechanisms.
Investigating the Effects of a Physical Education (PE) Kit Intervention on Female Adolescent Body-esteem
Authors: McIntosh Sharon , Lane Andrew M. , Nicholls Wendy , Devonport Tracey Jayne
Published: April 2023

It is widely acknowledged that adolescent females are particularly at risk of low body-esteem. Low body-esteem is associated with poor mental health and other negative outcomes. Interventions to help raise body-image could have considerable impact, especially if the intervention is low-cost, easy to implement and scalable. We investigated the efficacy of an intervention where participnants could chose their own clothes to wear during a Physical Education (PE lesson) on changes in body-esteem. We hypothesized that body-esteem would improve with choice. To show that body-esteem is not a transient construct, we tested its stability when assessed in a test-retest design when completed in a classroom setting, hypothesizing body-esteem would be stable. Participants (N =110; Mage =14.9; SDage = 0.68) females completed a 14-item body-esteem scale 4 times; a) wearing school uniform in an assembly, b) during a PE lesson separated by a 2-week gap. The intervention was implemented where students got a choice of PE kit and could wear their own clothes. Findings indicate that body-esteem was stable in the classroom setting where clothes and context were stable, but improved significantly when participants were given a free choice of kit to wear during PE. We argue that this low-cost and scalable intervention represents a useful start point for helping support low body-esteem among a potentially vulnerable population.
Konsep Hutan Bakau sebagai Konsep untuk Mitigasi Tsunami di Banda Aceh, Indonesia
Authors: Senjana Suci , Djafar Tasliati , Putri Rufia Andisetyana
Published: April 2023

Pada tahun 2004, tsunami Samudra Hindia melanda Kota Banda Aceh, ibu kota provinsi Nanggroe Aceh Darussalam, dengan gelombang setinggi 11 meter. Peristiwa ini menjadikan banyak pihak sadar dan memberi perhatian untuk melindungi kota dari ancaman bahaya alam tidak terduga di masa depan. Berkembang penelitian-penelitian yang mengusulkan solusi berbasis alam, terutama penggunaan vegetasi untuk dapat mendukung tanggul dalam mengurangi kecepatan aliran air tsunami, diantaranya melalui penggunaan tanaman bakau. Tujuan penelitian ini adalah untuk mengembangkan penggunaan hutan bakau untuk mendukung tanggul struktural dalam meningkatkan kapasitas mitigasi tsunami di garis pantai Banda Aceh. Studi ini diawali dengan survei dan observasi wilayah pesisir Kota Banda Aceh yang dilanjutkan dengan penggunaan metode projective design strategy untuk membuat perencanaan skenario hutan bakau pada perencanaan lanskap garis pantai Kota Banda Aceh. Analisis data sekunder dengan menggunakan literatur membantu menyusun kerangka kerja konseptualisasi hutan bakau di Kota Banda Aceh. Tanaman bakau sebagai elemen lanskap dan penerapannya sebagai hutan bakau menjadi fokus penelitian ini. Alih-alih membandingkan mana yang harus dipilih antara tanaman bakau dan tanggul, penelitian ini meninjau bagaimana keduanya digunakan dan bermanfaat bagi masyarakat dan ekosistem. Hasil dari penelitian ini adalah konsep skenario pemanfaatan hutan bakau dengan jarak 1,5 km dari bangunan dan mendampingi fungsi tanggul serta jalur evakuasi dalam usaha mengurangi kerusakan akibat tsunami yang mungkin akan terjadi. Oleh karena itu, penelitian ini tidak mengkritik penggunaan tanggul struktural, tetapi mengembangkan pengetahuan bagi para praktisi dan pemangku kepentingan untuk menyelidiki opsi dalam melengkapi strategi perencanaan dan desain kota dalam isu ini untuk berpartisipasi dalam pembangunan berkelanjutan.
Magnetovariational Sounding in South Vietnam according to the Dalat Observatory Data
Authors: Starzhinskii S.S.
Published: April 2023

—This paper describes a three-dimensional inversion of magnetovariational tippers calculated for the Dalat observatory in South Vietnam on the basis of the geomagnetic variation records obtained from the INTERMAGNET network. The frequency dependences of the tippers are inverted using the ModEM software, which makes it possible to construct a geoelectric model of the Dalat zone in a 300 × 300 × 150-km spatial region (x, y, and z axes, respectively) with its center located at the observatory. The resulting model of the geoelectric section contains both surface and deep conductive blocks located at the top and bottom of the Earth’s crust and in the upper mantle. The central part of the upper local conducting block with a resistivity of 0.5–1.0 Ohm⋅m is located near the observatory at a depth of 12–14 km. A more massive conductive block is located to the east of the observatory in the coastal region. Its central part with a resistivity of 0.3 Ohm⋅m is located at a depth of 24–28 km and extends under the continent along the coast for about 80 km. The roots of this block are visible to depths of ~100 km in the South China Sea shelf region. It is assumed that the high electrical conductivity of these blocks is provided by melting in the presence of aqueous fluids and granite series rocks, which are widely distributed in the Dalat zone. The crystallization depths of the samples of these granites estimated from the geothermobarometry data are close to the depth intervals of conductive blocks in the model section, which was also observed in the interpretation of magnetotelluric soundings in Southern Tibet, where granitoid rocks are widespread.
Plan de negocio para la producción y comercialización de alimento natural BARF para perros en el ámbito de Lima Moderna: Miraflores y San Borja
Authors:   , Huachalla Cahuana Ana Rocio , Livio Merino Naisha Alessandra , Barnet Valenzuela Paul Felipe , Vasquez Del Solar Fernando Javier , Sanez Rodríguez Flor
Published: April 2023

Descripción del Producto: Alimento 100% natural para perros sin preservantes, saborizantes o colorantes artificiales. Presentaciones: Alimento triturado - Alimento Entero. Precio: 22.29 Soles. Propuesta de Valor: “Diseñamos una dieta con los nutrientes estrictamente necesarios para tu mascota que mejora su digestión y fortalece su sistema inmunológico previniendo la aparición de enfermedades además el producto es elaborado con insumos 100% naturales libre de saborizantes, ingredientes artificiales además el alimento es empaquetado en un envase Biodegradables de fácil manipulación y conservación que permite brindar la porción adecuada para el engreído de la casa.” Modelo de Negocio: E-Comerce. Método de distribución: Motorizados. Alcance Geográfico de Distribución: Distritos de Miraflores y San Borja (Provincia: Lima - Departamento: Lima - Pais: Peru). Público Objetivo: Personas de 25 a 55 años. Personas que vive en los distritos de Lima Moderna. Personas pertenecientes al nivel Socioeconómico A y B. Personas que realizan múltiples actividades diarias relacionadas al trabajo, actividad física, Hobbies, familia, pareja, etc. Personas que consideran al can como un miembro de la familia.
Aplicaciones de la tomografía computarizada de haz cónico de la estructura craneofacial en especialidades médicas. Una revisión a la literatura.
Authors:   , Muñoz Galván Agustín
Published: April 2023

La tomografía computarizada de haz cónico (TCHC) de la estructura craneofacial que ha demostrado su utilidad en el área odontológica durante las últimas décadas se ha convertido en una herramienta fundamental en el diagnóstico, planeación y evaluación del tratamiento, no fue desarrollada para odontología como comúnmente se considera sino también para su uso en áreas médicas. En el área de cabeza y cuello interactúan diferentes especialidades médicas y a la vez estas interactúan con especialidades odontológicas por lo que conocer las ventajas que presenta la TCHC sobre diferentes tecnologías imagenológicas y por lo cual se está utilizando en medicina de manera intencional, siendo una ventaja para los médicos en diferentes especialidades. El conocer las ventajas de la TCHC ha permitido el uso de manera protocolizada y continúan evaluándose posibilidades para la observación, diagnóstico, plan de tratamiento, y evolución en diferentes especialidades médicas donde ya inclusive se considera estándar de medición.
Capacidad de autocuidado de los adultos mayores que asisten al Centro de Salud San Juan de Miraflores, 2020
Authors:   , Cupe Luque Susana Yanet
Published: April 2023

Objetivo: Describir la capacidad de autocuidado de los adultos mayores que asisten al centro de salud San Juan de Miraflores, 2020. Métodos: Estudio de investigación aplicada con enfoque cuantitativo, de nivel descriptivo, diseño no-experimental transversal con muestra de 304 adultos mayores, entre 60 y 93 años. Se aplicó la encuesta CYPAC-AM que evalúa la capacidad de autocuidado del adulto mayor, la cual constó de 8 dimensiones. Resultados: En las características socio demográficas de los adultos mayores 155 (51%) fueron hombres y 149 (49%) fueron mujeres. El rango más frecuente fue entre la edad de 60 a 69 años, la cual 80 mujeres representan el 26% y 76 hombres representan el 25%, con una cantidad total de 156 adultos mayores que representan el 51%. En la capacidad de autocuidado en el adulto mayor se encontró el grado de autocuidado adecuado en sus dimensiones: alimentación, eliminación, descanso y sueño, actividad física, adicciones o hábitos tóxicos e higiene y confort. En tanto en la dimensión medicación presenta un autocuidado parcialmente adecuado y en el control de la salud un autocuidado inadecuado. Conclusiones: En el estudio se ha podido encontrar que el puntaje más alto en la capacidad de autocuidado general en el adulto mayor es el autocuidado parcialmente adecuado con un 79%.
Resistencia in vitro a la fatiga cíclica de dos limas reciprocantes reciproc blue y rec blue file con y sin inmersión en hipoclorito de sodio
Authors:   , Vernal Carrillo Gianella Mirella
Published: April 2023

Objetivo: Comparar la resistencia a la fatiga cíclica de los instrumentos de niquel-titanio (NiTi) Reciproc Blue (RB) y Rec Blue file (RBF) con y sin inmersión en hipoclorito de sodio (NaOCl) al 5%. Materiales y Métodos: Estudio experimental in vitro aplicado en una muestra de 36 limas reciprocantes de 25 mm de longitud distribuidas en cuatro grupos según tipo de lima (RB y RBF) y de inmersión en NaOCl por 5 minutos (con y sin). Se midió el tiempo de resistencia a la fatiga cíclica en segundos (s) en canal simulado con ángulo de 45°. Resultados: El tiempo de resistencia a la fatiga cíclica fue estadísticamente inferior en la lima RBF con inmersión (123,53 s) en comparación a los demás grupos (256,40 s a 302,58 s) (P=0,000). Hubo interacción significativa entre el tiempo y los factores de tipo de lima e inmersión de forma individual (P=0,001) y por interacción (P=0,001). Conclusiones: Las limas RB tuvieron un comportamiento adecuado independientemente de la exposición en NaOCl al 5% a diferencia de las limas RBF que ante la inmersión mostraron menor tiempo de resistencia a la fatiga cíclica.
Uso de captadores de micotoxinas en pollos de engorde sobre el rendimiento productivo, digestibilidad de nutrientes, valores sanguíneos y bioquímicos y humedad de cama
Authors:   , Montalvo Solano Pamela , Seghelmeble Carreon Oscar Fabian
Published: April 2023

El estudio tuvo como objetivo evaluar el efecto de diferentes captadores de micotoxinas en pollos de engorde sobre los índices productivos, valores sanguíneos y bioquímicos, retención de nutrientes, humedad de cama y lesiones causadas por micotoxinas en pollos de 1 a 42 días. Se utilizaron 380 pollos de engorde divididos en 4 tratamientos, control negativo-dieta estándar sin micotoxinas; control positivo-dieta con micotoxinas sin aditivos; T3, dieta con micotoxinas + captador A (silicoglycidol® + ácidos orgánicos); T4, dieta con micotoxinas + captador B (silicoglycidol® + protector hepático) considerando 5 repeticiones con 19 pollos por repetición. Las aflatoxinas se elaboraron artificialmente y posteriormente se incluyeron en las dietas. Las evaluaciones se realizaron a los 42 días de edad. Se evidenció que las aves con captador A y B estadísticamente (p<0.05) presentaron mayor peso final, mayor ganancia de peso, además, mejor conversión alimenticia y menor mortalidad en comparación con el control positivo y negativo. De la misma manera para los indicadores como peso del ave, peso de pechuga, rendimiento de pechuga, peso muslo y rendimiento muslo y retención de nutrientes en comparación con los controles (p<0.05). Las aves con el tratamiento control negativo y los tratamientos con captadores presentaron mayores niveles de hemoglobina, mayor cantidad de leucocitos, menor cantidad de eosinófilos, cantidades normales de neutrófilos y porcentaje normal de hematocrito. Se observó niveles más elevados (p<0.05) de aspartato aminotransferasa (AST), gamma glutamil transpeptidasa (GGT), fosfatasa alcalina sérica (FA) y colesterol para las aves con dietas sin captadores. En las evaluaciones sobre las heces se halló menores porcentajes de nitrógeno total y en la cama se halló menores porcentajes de humedad en los tratamientos con captador A y B (p<0.05) al compararlos con los controles. Se observó en el control positivo mayor porcentaje de aves con hepatomegalia, cambio de...
Relación del tercer molar y el seno maxilar en una muestra de adultos peruanos mediante radiografías panorámicas
Authors:   , Meza García Gonzalo Guillermo
Published: April 2023

El estudio tuvo como objetivo determinar la relación de las terceras molares superiores y el seno maxilar adyacente mediante la evaluación de su profundidad relativa, ángulo y relación espacial en radiografías panorámicas de una muestra de peruanos. La muestra fue de 400 radiografías de usuarios de 25 a 40 años (237 mujeres y 163 hombres) obtenidas de un centro radiológico privado ubicado en Lima entre los años 2019 – 2020. La imágenes de calidad adecuada de terceros morales superiores bilaterales fueran evaluadas con software radiográfico según tres parámetros: relación espacial (tipo 1 al 5), la angulación (distoangular, vertical y mesioangular) y la profundidad relativa (clase A al C). La estadística aplicada fue la prueba de Chi cuadrado. Los resultados más frecuentes fueron la relación espacial tipo 2, con angulación en posición distoangulada y profundidad relativa Clase A. Los resultados fueron similares por lado y sexo. Se concluye que hubo un predominio del tercer molar con ápices en una proyección parcial del seno maxilar, con el eje en dirección opuesta al del segundo molar, y plano ubicado entre la línea oclusal del segundo molar y su línea cervical.
Régimen jurídico del comercio exterior peruano y acuerdos multilaterales de comercio exterior entre los años 2010-2020
Authors:   , Camasi Huaman Donato
Published: April 2023

La investigación “RÉGIMEN JURÍDICO DEL COMERCIO EXTERIOR PERUANO Y ACUERDOS MULTILATERALES DE COMERCIO EXTERIOR ENTRE LOS AÑOS 2010-2020” basada en el problema de la adecuación peruana de su normativa aduanera y de comercio exterior para la facilitación de sus procesos y el encontrarse aún relegados respecto a países de la región como México y Chile nos dice que tenemos aún que mejorar. El objetivo general en esta investigación es encontrar algún grado de relación entre estas dos variables, para ello se utilizó el enfoque cuantitativo, de alcance relacional, utilizando para ello datos retrospectivos recopilados de la superintendencia nacional de administración tributaria, específicamente del plan estratégico institucional en cuyo interior se encuentra el informe de evaluación de resultados, Informes de Evaluación Anual del Plan Estratégico Multianual del Ministerio de Economía y Finanzas, así como de indicadores de Perfiles Arancelarios y Comerciales que pertenecen a l organismo mundial del comercio. Tomando como estadístico el coeficiente de relación de Pearson se tuvo como resultados la existencia de un alto grado de relación entre las variables, corroborado así en el análisis estadístico y respaldado por los antecedentes y el marco teórico. A nivel descriptivo se obtuvo que de las 23 muestras recolectadas que consistían en documentos con referencia a los acuerdos de comercios multilaterales han permitido que nuestro país realice una adecuación a estos acuerdos de facilitación y cooperación aduanera permitiendo una mejora en Líneas Arancelarias Libres Derechos, así como el tiempo estimado para liberar mercadería de tipo importado y en recaudación aduanera en el periodo de estudio. Esto significa que las adecuaciones en el régimen jurídico realizadas por el Perú en materia de facilitación aduanera desde el año 1990 han servido para que el Perú mejoré en las variables analizadas, pero aún estamos atrás de otras realidades latinoamericanas.
Estilos de vida y bienestar psicológico en estudiantes de Psicología de una universidad privada de Lima
Authors:   , Cubas Julca Elva Consuelo , Cusipuma Sanches Daysy
Published: April 2023

La presente investigación tiene como objetivo examinar la relación entre los estilos de vida y el bienestar psicológico en estudiantes de psicología de una universidad privada de Lima. El diseño fue descriptivo correlacional, la muestra estuvo conformada por 201 estudiantes (80.1% mujeres y 19.9 % varones) y se emplearon los instrumentos: Cuestionario de estilos de vida de jóvenes universitarios – CEVJU-r Lima y Escala de bienestar psicológico de Carol Ryff. Los resultados evidencian que los universitarios se caracterizan por mantener estilos de vida no saludables (72.1 %) y presentar un nivel medio de bienestar psicológico (93 %). Así mismo, existe una relación significativa entre ambas variables estudiadas, siendo las áreas de “dominio del entorno”, “propósito en la vida”, “crecimiento personal”, “relaciones positivas” y “autoaceptación”, variables que guardan mayor relación con las conductas de salud. En conclusión, los estilos de vida son un factor predominante para obtener bienestar psicológico, siendo necesario que este grupo humano ponga en práctica sus propios conocimientos sobre temas de salud con la finalidad de prevenir conductas que afecten su bienestar emocional. Asimismo, se deben aplicar programas que fortalezcan estos aspectos en los estudiantes de Psicología.
Cultura organizacional y su relación con el work engagement en trabajadores del área de riesgos de una empresa del sector bancario, Miraflores (Lima - Perú), 2022
Authors:   , Flores Coral Alexander
Published: April 2023

El objetivo de la investigación fue determinar la relación entre la cultura organizacional y el work engagement en los trabajadores del área de Riesgos de una empresa del Sector Bancario en el distrito de Miraflores (Lima - Perú), 2022. La investigación se ejecutó mediante muestreo probabilístico, aleatorio simple. Aplicándose un diseño no experimental, transversal, correlacional. La población para el estudio fue de 122 trabajadores; no obstante, se trabajó con una muestra significativa, considerando un nivel de confianza al 95% y un margen de error del 5%. Por lo que, la muestra fue de 93 trabajadores. Para el despliegue del instrumento se consideró una encuesta, la que estuvo compuesta por 21 ítems. Asimismo, se adaptaron para la investigación los cuestionarios Utrecht Work Engagement Scale (UWES) y Denison Organizational Culture Survey (DOCS). Para el análisis inferencial se aplicó el estadístico de Rho de Spearman. Los resultados de la investigación revelaron una correlación fuerte y positiva (Rho = ,620) entre las variables con un nivel de significancia menor a 5 % (p-valor < 0.05) con 93 casos relacionados. Por lo que, se aceptó la hipótesis de la investigación: La Cultura Organizacional está relacionada con el Work Engagement.
Tratamiento de aguas subterráneas de consumo humano mediante filtros de zeolita y arena en la V estapa de Ciudad Constitución, Oxapampa, Perú
Authors:   , Tucto Cueva Edwar , Oscco Medina Grecia Thane
Published: April 2023

El agua es de vital importancia en la gestión ambiental, y viene siendo amenazado por diversos factores, que proyectan una crisis severa afectando principalmente pozos y nacientes debajo de la superficie. El objetivo de la investigación fue comparar el tratamiento de aguas subterráneas de consumo humano mediante filtros de zeolita y arena en la V etapa de Ciudad Constitución. Se establecieron cinco pozos de muestreo en base a la afluencia de personas, y se tomaron muestras de agua para el análisis fisicoquímico y microbiológico en época seca y lluviosa. Se determinó el pozo con menor índice de calidad del agua -ICA como control, y se construyeron filtros de zeolita y arena, para conocer la eficiencia con el mismo método a la salida del sistema. Se encontró una correlación perfecta positiva entre el parámetro de Conductividad eléctrica y Sólidos totales disueltos (Std), aunque también se presentaron otros pares de importancia. Para el análisis de componentes principales se observó un solo núcleo de agrupamientos para la época seca, y dos agrupamientos para la época lluviosa. Los resultados no son relevantes en ninguna época del año para el parámetro de pH, otros parámetros como el Hierro, Cloruros y Amonio, Conductividad eléctrica, dureza, alcalinidad, y bacterias heterotróficas, muestran valores no significativos, o menos relevantes al control. Sin embargo, representan métodos efectivos para disminuir la Turbiedad, y eliminar el contenido de bacterias coliformes; que le permiten ser eficientes como indicadores de calidad del agua, donde el filtro de Zeolita es más eficaz para los parámetros fisicoquímicos, y el filtro de arena para los parámetros biológicos.
Tissue distribution and correlations of heavy metals in wild birds from Southern Turkey: an ecologically important region on the west Palearctic migration route
Authors: Yipel Mustafa , TEKELİ İbrahim Ozan , İŞLER Cafer Tayer , ALTUĞ Muhammed Enes
Published: April 2023

Even if some are essential for biological functions, the accumulation of heavy metals above tolerable physiological limits is potentially toxic to also wild animals. The present study aimed to investigate concentrations of environmentally relevant heavy metals (As, Cd, Cu, Fe, Hg, Mn, Pb, and Zn) in feathers, muscle, heart, kidney, and liver tissues of wild birds (golden eagle [Aquila chrysaetos], sparrowhawk [Accipiter nisus], and white stork [Ciconia ciconia]) from Hatay province, southern Turkey. The metal concentrations of tissues were determined by a validated ICP-OES analysis method after microwave digestion. The concentration differences of metals in species/tissues and the correlations between essential/non-essential metals were determined by statistical analysis. According to the results, Fe (326.87 ± 3.60 mg kg− 1) had the highest, and Hg (0.09 ± 0.00 mg kg− 1) had the lowest mean concentration in all tissues. Compared to the literature; Cu, Hg, Pb, and Zn concentrations were lower; Cd, Fe, and Mn concentrations were higher. The correlations between As and all essentials; Cd and Cu, Fe; Hg and Cu, Fe, Zn; Pb and all essentials were significantly positive. In the conclusion, while essential Cu, Fe, and Zn are below the threshold value and do not pose a risk, Mn is close to the threshold value. Therefore, periodically monitoring the pollutant concentrations in bioindicators is a key necessity for the early determination of biomagnification trends and prevention of potential toxic stress on wildlife ecology.
MEsh FIxation in Laparoendsocopic Repair of Large M3 Inguinal Hernias - Multicenter, Double-blinded, Randomized Controlled Trial – study protocol for a MEFI Trial
Authors: Zamkowski Mateusz , Śmietański Maciej
Published: April 2023

• Background
Guidelines of groin hernia treatment strongly recommends to fixate the mesh in large M3 medial defects during TAPP / TEP procedures. Main purpose of fixation is to decrease recurrence rate which is alarmingly high in case of those defects. In 2022 team consisting of hernia surgeons and scientists from universities of technology conducted an experimental study with the use of 3d groin model to verify the hypothesis that fixation is not necessary in above cases. Experiment showed that rigid and anatomically shaped meshes are able to maintain its position in groin without fixation. Similar conclusions were recently published in Swedish database registry analysis. To confirm above results we decided to conduct multicenter randomized controlled trial..
• Methods
Main objective of MEFI Trial is to verify the hypothesis that non-fixation of spatial, standard polypropylene meshes is non-inferior to fixation of flat, polypropylene lightweight meshes in M3 hernias by laparoendoscopic approach. 11 large surgery centers in Poland having proficiency in laparoendoscopic groin hernia repairs were recruited for this study. Recurrence in 12-month follow-up was set as a primary endpoint. Pain sensation (Visual Analog Scale) and incidence of other complications (hematoma, seroma, SSI) were also noted. Based on the statistical analysis, minimal sample size in both arms was established at 83–102. First arm (control) consists of patients undergoing a repair with the use of flat, macroporous mesh with fixation using histoacryl glue. In second arm patients will be operated with the use of anatomically shaped, standard-weight mesh without fixation. Study will be double-blinded (patient/surgeon). After dissection of preperitoneal space, surgeon will open sealed envelope and find out which technique he will have to perform. Follow-up will be performed by Study Secretary (also blinded to method used) via phone call 3 and 12-months after surgery..
• Discussion
Based on experimental study and recent registry analysis, we believe that recurrence rate in both groups would be on the same level, giving hernia societies strong argument for amending the guidelines..
Trial registration
ClinicalTrials.gov Identifier: NCT05678465 registered on January 10, 2023
General Skin and Nasal Decolonization with octenisan® Set before and after Elective Orthopedic Surgery in Selected Patients at Elevated Risk for Revision Surgery and Surgical Site Infections - A Single-Center, Unblinded, Superiority, Randomized-Controlled Trial (BALGDEC Trial)
Authors: Unterfrauner Ines , Bragatto-Hess Nadja , Studhalter Thorsten , Farshad Mazda , Uçkay Ilker
Published: April 2023

Background
The preoperative body surface and nasal decolonization may reduce the risk of surgical site infections (SSI), but yields conflicting results in the current orthopedic literature.
Methods
We perform a single-center, randomized-controlled, superiority trial in favor of the preoperative decolonization using a commercial product (octenidin® set). We will randomize a total number of 1,000 adult elective orthopedic patients with a high risk for SSI and/or wound complications (age ≥ 80 years, chronic immune-suppression, American Society of Anesthesiologists’-Score 3–4 points) between a decolonization (octenisan® wash lotion 1 x per day and octenisan® md nasal gel 2–3 x per day; during five days) and no decolonization. Decolonized patients will additionally fill a questionnaire regarding the practical difficulties, the completeness, and the adverse events of decolonization. The primary outcomes are SSI and revision surgeries for postoperative wound problems until six weeks postoperatively (or 1 year for surgeries with implants or bone). Secondary outcomes are unplanned revision surgeries for non-infectious problems and all adverse events. With 95% event-free surgeries in the decolonization arm versus 90% in the control arm, we formally need 2 x 474 elective orthopedic surgeries included during two years.
Discussion
In selected adult orthopedic patients with a high risk for SSI, the presurgical decolonization may reduce postoperative wound problems, including SSI.
Trial registration
ClinicalTrial.gov NCT05647252. Registered on 9 December 2022.
Protocol version
2 (5 December 2022)
FP receptor structures reveal the selectivity mechanism of prostaglandin
Authors: Liu Xiangyu , Lv Xiuqing , Gao Kaixuan , Nie Jia , Zhang Xin , Zhang Shuhao , Ren Yinhang , Sun Xiaoou , Li Qi , Huang Jingrui , Liu Lijuan , Zhang Xiaowen , Zhang Weishe
Published: April 2023

Prostaglandins and their receptors regulate various physiological processes, such as cardiovascular homeostasis, body temperature control and female production. Carboprost, an analog of prostaglandin F2α and an agonist for the prostaglandin F2-alpha receptor (FP receptor), is clinically used to treat postpartum hemorrhage (PPH), which is a leading cause of maternal morbidity and mortality. However, off-target activation of closely related receptors such as the EP3 receptor by carboprost results in side effects and limits the clinical application. Meanwhile, the FP receptor selective agonist latanoprost is not suitable to treat PPH due to its poor solubility and fast clearance. In this work, we determined two cryo-EM structures of the FP receptor bound to carboprost and latanoprost at 2.7 Å and 3.2 Å resolution, respectively. The structures reveal the molecular mechanism of FP receptor selectivity for both endogenous prostaglandins and clinical drugs, as well as the molecular mechanism of G protein coupling preference by the prostaglandin receptors. The structural information may guide the development of better prostaglandin drugs.
The Japanese nationwide cohort data of proton beam therapy for liver oligometastasis in breast cancer patients
Authors: Yamaguchi Hisashi , Fukumitsu Nobuyoshi , Numajiri Haruko , Ogino Hiroyuki , Okimoto Tomoaki , Ogino Takashi , Suzuki Motohisa , Murayama Shigeyuki
Published: April 2023

Purpose: A nationwide multicenter cohort study on particle therapy was launched by the Japanese Society for Radiation Oncology in Japan in May 2016. We analyzed the outcome of proton beam therapy (PBT) for liver oligometastasis in breast cancers.
Methods: Cases in which PBT was performed at all Japanese proton therapy facilities between May 2016 and February 2019 were enrolled. The patients were selected based on the following criteria: the primary cancer was controlled, liver recurrence without extrahepatic tumors, and no more than three liver lesions.
Results: Fourteen females with a median age of 57 (range, 44–73) years and twenty-two lesions were included. The median lesion size, fraction size, and biological effective dose (BED)10 were 44 (20–130) mm, 6.6 (2-8) gray (Gy) (relative biological effectiveness [RBE])/fraction (fr), and 109.6 (52.7-115.2) Gy, respectively. The median follow-up period was 22.8 (4-54) months. The 1-, 2-, and 3-year local control (LC) rates of liver metastasis from breast cancer were 100% for all. The 1-, 2-, and 3-year overall survival rates were 85.7%, 62.5%, and 62.5%, respectively. The 1-, 2-, and 3-year progression free survival (PFS) rates were 50.0%, 33.3%, and 16.7%, respectively. The median PFS time was 16 months. Only one patient did not complete PBT due to current disease progression. One patient had grade 3 radiation-induced dermatitis. None of the patients experienced radiation-induced liver failure during the acute or late phase.
Conclusions: Owing to the low incidence of adverse events and the high LC rate, PBT appears to be a feasible option for liver oligometastasis in breast cancers.
Ferrimagnetic Regulation of Weyl Fermions in a Noncentrosymmetric Magnetic Weyl Semimetal
Authors: Li Cong , Zhang Jianfeng , Wang Yang , Liu Hongxiong , Guo Qinda , Rienks Emile , Chen Wanyu , Bertran Francois , Yang Huancheng , Phuyal Dibya , Fedderwitz Hanna , Balasubramanian Thiagarajan , Dendzik Maciej , Berntsen Magnus H. , Shi Youguo , Xiang Tao , Tjernberg Oscar
Published: April 2023

The study of interaction between electromagnetism and elementary particles is a long-standing topic in physics. Likewise, the connection between particle physics and emergent phenomena in condensed matter physics is a recurring theme and condensed matter physics has often provided a platform for investigating the interplay between particles and fields in cases that have not been observed in high-energy physics, so far. Here, using angle-resolved photoemission spectroscopy, we provide a new example of this by visualizing the electronic structure of a noncentrosymmetric magnetic Weyl semimetal candidate NdAlSi in both the paramagnetic and ferrimagnetic states. We observe surface Fermi arcs and bulk Weyl fermion dispersion as well as the regulation of Weyl fermions by ferrimagnetism. Our results establish NdAlSi as a magnetic Weyl semimetal and provide the first experimental observation of ferrimagnetic regulation of Weyl fermions in condensed matter.
The Effect of War on Health Institutions of Eastern Tigray Zone, Tigray State, Ethiopia
Authors: Tekulu Fikre Belay , Gebre Haftom Teshale , Hailu Hagos Gebremariam , Asgedom Desalegn Birhane , Desta Gebretsadikan Mulubrhan , Shifare Tsigab Hagos , Hadigu Tadesse Birhane
Published: April 2023

The aim of this study was to examine the impact of war on damage to health facilities in the Eastern Tigray Zone. The study used both quantitative and qualitative methods such as questionnaires, interviews, focus group discussions, and observations used for data collection. A simple random sample was used to select participants. The study found that 97.9 percent of households surveyed believe the impact of war on healthcare facilities is high to very high. The study used a linear regression model. The result shows a statistically significant and war-declared 55.8 percent of the observed damage to healthcare facilities. Of 177 healthcare facilities, 29 (16.4 percent) and 118 (66.66 percent) respectively faced severe or total losses. This suggests that 83 percent of the East Zones' health systems were damaged. This damage to health facilities has taken a toll on the health system at the zone level. Therefore, the government and affected people should contribute to the reconstruction and restoration of health facilities and ensure national security (economic, political, social, and other security)
Transcriptome sequencing and metabolome analysis reveal metabolic reprogramming of partial hepatectomy and extended hepatectomy
Authors: Li Zeyuan , Peng Bo , Chen Shilian , Li Jiaping , Hu Kai , Liao Lijuan , Xie Qiuli , Yao Mei , liang Lixing , Tomlinson Stephen , Yuan Guandou , He Songqing
Published: April 2023

Surgical resection remains a critical treatment option for many patients with primary and secondary hepatic neoplasms. Extended hepatectomy (eHx) may be required for some patients with large tumors, which may cause liver failure and individual death. Partial hepatectomy (pHx) and eHx mouse models were constructed, liver tissues were sampled at 18, 36, and 72 h post-hepatectomy, transcriptome and metabolome analyses were employed to find the differences in regeneration and injury between pHx and eHx. The results showed that eHx was associated with more severe liver injury and lower survival rates compared with pHx. Compared with the sham groups, transcriptomics data showed there were 1842, 2129, and 1277 differentially expressed genes (DEGs) in eHx and 962, 1305, and 732 DEGs in pHx at 18, 36, and 72 h post-hepatectomy, respectively. Compared with pHx, the number of DEGs reached a maximum of 230 at 18 h after surgery and decreased sequentially to 87 and 43 at 36 h and 72 h. Metabolomics analysis identified a total of 1399 metabolites, and 48 significant differentially produced metabolites (DPMs) were screened between eHx and pHx. Combined analysis of DEGs and DPMs indicated that cholesterol metabolism and insulin resistance may be two important pathways to liver regeneration and mouse survival post-extended hepatectomy. Our results showed the global influence of pHx and eHx on the transcriptome and metabolome in mouse liver, as both cholesterol metabolism and insulin resistance pathways were altered both at the transcriptional and metabolic levels between pHx and eHx groups.
Meta-analysis of the effect of high-intensity statin on coronary microvascular dysfunction
Authors: Huang Bihan , Han Xueying , Pan Yun , Chen Dongdong
Published: April 2023

Objective: The purpose of this meta-analysis is to evaluate the role of high-intensity statin pretreatment on coronary microvascular dysfunction in patients with coronary heart disease undergoing percutaneous coronary intervention (PCI). Methods: PubMed, Cochrane and Embase were searched. This meta-analysis selection included randomized controlled trials (RCTs), involving high-intensity statin pretreatment as active treatment, and measurement of thrombolysis in myocardial infarction (TIMI), myocardial blush grade (MBG) or index of microvascular resistance (IMR) in coronary heart disease (CHD) patients undergoing PCI. I 2 test was used to evaluate heterogeneity. Pooled effects of continuous variables were reported as Standard mean difference (SMD) and 95% confidence intervals (CI). Pooled effects of discontinuous variables were reported as risk ratios (RR) and 95% confidence intervals (CI). Random-effect or fix-effect meta-analyses were performed. Benefit was further examined based on clinical characteristics including diagnosis and statin type by using subgroup analyses. Publication bias was examined by quantitative Egger’s test and funnel plot. We performed sensitivity analyses to examine the robustness of pooled effects.
Results: Twenty RCTs were enrolled. The data on TIMI ＜ 3 was reported in 18 studies. Comparing with non-high-intensity statin, high-intensity statin pretreatment significantly improved TIMI after PCI (RR=0.62， 95%CI： 0.50 to 0.78， P＜0.0001). The data on MBG＜2 was reported in 3 studies. The rate of MBG＜2 was not different between groups (RR=1.29，95% CI： 0.87 to 1.93，P=0.21). The data on IMR was reported in 2 studies. High-dose statin pretreatment significantly improved IMR after PCI comparing with non-high-dose statin (SMD=-0.94，95% CI：-1.47 to-0.42，P=0.0004). There were no significant between-subgroup differences in subgroups based on statin type and diagnosis. Publication bias was not indicated by using quantitative Egger’s test (P=0.97) and funnel plot. Sensitivity analyses confirmed the robustness of these findings.
Conclusions: Comparing with non-high-intensity statin, high-intensity statin pretreatment significantly improved TIMI and IMR after PCI. In the future, RCTs with high quality and large sample are needed to test these endpoints.
Association between internet addiction and suicide and self-injury behavior in Chinese adolescents: A meta-analysis
Authors: He Xubin , Yu Qinyao , Yang Bo , Yang Ping , Du Na , Yue Yuchuan
Published: April 2023

Background: Internet addiction (IA) has become a significant social issue, with studies indicating a correlation between adolescent suicide, self-injury, and IA. However, the nature of this correlation among Chinese teenagers remains unclear. This research aimed to clarify the relationships between IA and suicidal and self-injury behaviors among Chinese adolescents through a meta-analysis of observational studies.
Methods: We searched seven electronic databases from inception to January 16, 2023. Study quality was assessed by the AHRQ and the NOS. We extracted the effect values (OR) of IA and suicide, and self-injury behaviors using STATA (version 16) software for data synthesis.
Results: Out of 836 initial studies, 26 cross-sectional (n = 376742) and two prospective (n = 1831) studies were selected to examine the association between IA and suicide and self-injury behaviors in Chinese adolescents. IA was significantly linked to increased odds of suicidal ideation (OR = 1.81, 95% CI: 1.46-2.24), suicide planning (OR = 1.85, 95% CI: 1.36-2.52), suicide attempt (OR = 1.78, 95% CI: 1.34-2.36), and non-suicidal self-injury (OR = 1.91, 95% CI: 1.58-2.31). Subgroup analysis suggested that regional differences, age, and publication year may regulate the association between IA and non-suicidal self-injury behavior. The study found that western China had the highest risk of non-suicidal self-injury, and middle school students were more vulnerable than college students. Moreover, teenagers with IA were found to be at a higher risk of non-suicidal self-injury over time. Additionally, age was identified as a significant moderator of the association between IA and suicidal ideation, with a lower likelihood of suicidal ideation in middle school students compared to college students.
Conclusion: This meta-analysis provides evidence of a positive association between IA and suicidal and self-injury behaviors among Chinese adolescents. It emphasizes the need for public health interventions that target IA and related mental health issues in this population.
1 Effect of plant spacing on growth and yield formation of sugar beet taproot
Authors: Xu Yao , Liu Dangyang , Shi Jing , Wang Xu , Wang Yuguang , Geng Gui , Yu Lihua , Lu Yuncai
Published: April 2023

To clarify the effect of plant spacing on the growth, yield formation, and quality of sugar beet taproot. We designed field experiments in 2021-2022, and sugar beet variety KWS1176 was used as experimental material, and 9 plant spacing treatments from 8cm to 32cm were set up. The morphological indicators, photosynthetic characteristics, and the nutrient contents were determined at the stages of the leafage growing period (V1), sugar increase period of taproot (V2), sugar accumulation period I of taproot (V3), and sugar accumulation period II of taproot (V4), and the root yield and quality parameters were measured at the harvest. The results showed that in the plant spacing treatments of 11cm and 14 cm, sugar beet had a suitable canopy structure and space for taproot growing. The canopy photosynthetic activity was higher, which provided sufficient photosynthetic products for root growth, and appropriate root size could balance root growth and sucrose accumulation. The highest root yield and sugar content were also obtained in the treatment of 14 cm plant spacing. With the increase of plant spacing, the yield of sugar beet decreased, and the content of α-amino N, K+, and Na+ in the root increased, which had a disadvantageous influence on the processing quality of the root. It was found that the number of cambial rings and the average distance between cambial rings could be used as qualitative indicators of the sugar content of taproot and the processing quality. Therefore, 11cm-14cm was recommended as a reasonable planting spacing to obtain higher taproot and sugar yield with better quality.