bluuebunny/crossref_metadata_2025 huggingface dataset:
Vedolizumab Treatment for Ulcerative Colitis in an Elderly Multimorbid Patient with Hemophilia A
Authors: Schäffler Holger , Huth Astrid , Lamprecht Georg , Anders Olaf
Published: December 2017

The treatment of inflammatory bowel diseases (IBD) can be challenging, especially in elderly multimorbid patients. Since incidence and prevalence rates of IBD are rising steadily, treatment of older patients with relevant and also rare comorbidities will be of increasing relevancy for caregivers. Here we report on a 74-year-old multimorbid patient with severe ulcerative colitis (UC) and hemophilia A. Because of the chronic active disease, therapy with a tumor necrosis factor-α inhibitor was started. He suffered from a severe infectious complication (pneumonia) under therapy with infliximab. The therapy was changed to vedolizumab, with which the patient stayed in long-term clinical and endoscopic remission. Because the patient had a non-ST-segment elevation myocardial infarction in April 2016, he received dual platelet inhibitor therapy with aspirin and clopidogrel. Because of consecutive aspirin intolerance, the therapy was changed to clopidogrel monotherapy. Although the UC was treated appropriately with vedolizumab and the patient was in endoscopic mucosal remission, recurrent bleeding episodes from multiple inflammatory pseudopolyps occurred. The bleeding episodes resolved quickly after immediate treatment with factor VIII (Kogenate®). In conclusion, we describe the first patient in the literature with UC and hemophilia A who stayed in long-term remission under therapy with vedolizumab. From our point of view, vedolizumab can be safely administered in the setting of UC and hemophilia A. Antiplatelet drugs which inhibit primary hemostasis must be used with caution in this setting. Bleeding episodes can be treated safely and effectively with factor VIII (Kogenate®).
Progressive Reduction in Myocyte Autophagy After Myocardial Infarction in Rabbits: Association with Oxidative Stress and Left Ventricular Remodeling
Authors: Chi Rui-Fang , Wang Jia-Pu , Wang Ke , Zhang Xiao-Li , Zhang Yue-An , Kang Yu-Ming , Han Xue-Bin , Li Bao , Qin Fu-Zhong , Fan Bian-Ai
Published: December 2017

Background/Aims: The alterations in myocyte autophagy after myocardial infarction (MI) and the underlying mechanisms have not been fully understood. In this study, we investigated the temporal changes of myocyte autophagy in the remote non-infarcted myocardium in rabbits after MI and the relationships between alterations of myocyte autophagy and left ventricular (LV) remodeling and myocardial oxidative stress. Methods: Rabbits were assigned to MI or sham operation. Rabbits with MI or sham were randomly assigned to receive chloroquine, an autophagy inhibitor, antioxidant vitamins C and E or placebo for 4 weeks. H9C2 cardiomyocytes were subjected to hypoxia or hydrogen peroxide (H2O2) treatment. Results: MI rabbits exhibited progressive increases of LV end-diastolic dimension (EDD), and decreases of LV fractional shortening (FS) and dP/dt over 8 weeks. Myocyte autophagy assessed by the scores of LC3 and Beclin1 expression was progressively decreased at 1, 4 and 8 weeks after MI. The ratio of LC3 II/I and Beclin1 and Atg5 proteins were also decreased at 4 weeks after MI. There was a negative correlation between autophagy and LV EDD and a positive correlation between autophagy and LV FS and dP/dt. The autophagy inhibitor chloroquine worsened LV remodeling after MI. Decreased myocyte autophagy was associated with increased myocardial 4-hydroxynonenal. Antioxidant vitamins C and E prevented the decrease in myocyte autophagy after MI. In cultured H9C2 cardiomyocytes, the LC3 II/I ratio was decreased at 4 and 8 h after exposure to hypoxia, and the change was associated with increased 8-hydroxy-2-deoxyguanosine. A low concentration of H2O2 decreased the LC3 II/I ratio. Conclusion: Progressive reduction in myocyte autophagy in the remote non-infarcted myocardium was associated with myocardial oxidative stress and LV remodeling after MI. Antioxidants prevented the reduction in myocyte autophagy after MI, suggesting that oxidative stress mediates reduction in myocyte autophagy that contributes to post-MI remodeling.
Redescrição dos girinos de Epipedobates narinensis e E. boulengeri (Anura: Dendrobatidae).
Authors: Anganoy-Criollo Marvin , Cepeda-Quilindo Belisario
Published: December 2017

The larval morphology of poison frogs (Dendrobatoidea) has contributed to an understanding of the phylogenetic relationships within the superfamily. Nevertheless, our knowledge of larval morphology is incomplete. The larvae of the dendrobatids, Epipedobates narinensis and E. boulengeri are redescribed, diagnosed, and differentiated from three congeners, as well as sympatric dendrobatoids and closely related genera. Three larval developmental phases are described—viz., (1) back-riding tadpoles, (2) free-swimming tadpoles, and (3) metamorphosing tadpoles. Each larval phase is characterized by ontogenetic changes in external morphology, and there is also morphological variation within each developmental phase. Ontogenetic morphological changes are the most marked in back-riding and metamorphosing phases. The external features of free-swimming tadpoles do not change abruptly, but ontogenetic changes occur in the marginal papillae, stitches of the lateral line system, and tail coloration. Four features that have not been considered previously distinguish species-groups and/or genera—moderate A-2 gap; presence of shelf on back of the upper jaw sheath [UJS]; moderate notch on mid-UJS; and nostril size; these characters are putative synapomorphies of Epipedobates. Metamorphosing tadpoles have some adult features, such as the color pattern on the hind limbs and basal toe webbing, which facilitate identification of species.
CHARLES BAUDELAIRE E O ESPIRITUAL NAS ARTES: UM ESTUDO COMPARATIVO ENTRE POESIA E PINTURA MODERNA
Authors: Gonçalves Aguinaldo José , Narvaes Giuliarde de Abreu
Published: December 2017

Não há como atravessar verticalmente a obra poética de Charles Baudelaire sem considerar em algum momento, e espera-se que não tarde, a persistência das correspondências poéticas. Neste trabalho, por meio de uma análise intersemiótica dos sistemas de linguagem, destacamos correspondências estruturais entre dois sonetos de Les Fleurs du mal e a modernidade plástica das obras de Wassily Kandinsky e Jackson Pollock. Aspecto fulcral e determinante às leituras comparadas que apresentaremos, a teoria das correspondências na poesia de Baudelaire torna-se assunto incontornável para qualquer abordagem comparatista entre sua poesia e as obras plásticas da modernidade.
A DIVULGAÇÃO DE GRACILIANO RAMOS EM PORTUGAL NAS PÁGINAS DA REVISTA "ATLÂNTICO": SUPORTE E ATENUAÇÃO DO SENTIDO
Authors: Salla Thiago Mio
Published: December 2017

Este artigo tem como objetivo examinar a colaboração de Graciliano Ramos com a revista luso-brasileira Atlântico, o mais importante elo editorial do intercâmbio literário e intelectual pactuado pelas ditaduras de Salazar e Vargas a partir do Acordo Cultural de 1941. Nesse processo investigativo, apresentam-se as diretrizes da política editorial do periódico e a ambiência discursiva com que ela enquadrava os textos. Em seguida, discute-se em que medida a dimensão crítica dos quadros memorialísticos publicados pelo autor alagoano em Atlântico procurava ser atenuada pela proposta do veículo de apresentar-se como um álbum luxuoso e enviesado de congraçamento literário entre as duas nações.
O CAVALO DE TODAS AS CORES DE JOÃO CABRAL E ALBERTO DE SERPA: UMA REVISTA TRIMESTRAL DE UM NÚMERO SÓ
Authors: Moreira Priscila Oliveira Monteiro , Athayde Manaíra Aires
Published: December 2017

No final dos anos 1940, João Cabral de Melo Neto correspondeu-se com o português Alberto de Serpa para propor a criação de um periódico a ser editado em sua tipografia artesanal, O Livro Inconsútil. A leitura da correspondência passiva depositada nos Arquivos Pessoais de Escritores Brasileiros, na Fundação Rui Barbosa, permitiu recompor o esforço dos poetas na organização da revista literária O Cavalo de Todas as Cores. Essa experiência editorial de João Cabral é parte significativa de sua produção, além de ser um espaço de resistência política à censura portuguesa, de afirmação da cultura catalã e de apresentação da poesia de língua portuguesa a públicos estrangeiros.
“MESENE”, CONTO ANGOLANO E “APESAR DE VOCÊ”, CANÇÃO BRASILEIRA: FORMAS DE RESISTÊNCIA
Authors: Lopes Estefânia Francis , Macêdo Tania Celestino
Published: December 2017

O presente artigo analisa o conto “Mesene”, do escritor angolano Boaventura Cardoso e a letra da canção “Apesar de você”, do compositor brasileiro Chico Buarque, com o fito de revelar, a partir das respectivas linguagens, a elaboração estética e a crítica social que emergem de obras escritas sob períodos de repressão, sendo configuradas, dessa forma, a partir de nossa leitura, como escritas de resistência.
EDUCAÇÃO LIBERTADORA E (RE)CONHECIMENTO DO NEGRO: A VOZ E A VEZ DAS LITERATURAS AFRICANAS DE LÍNGUA PORTUGUESA NAS SALAS DE AULA
Authors: Dias Mariana Sousa , Silva Renata Flavia da
Published: December 2017

Este artigo tem por objetivo discutir o estudo das Literaturas Africanas em Língua Portuguesa como importante expressão da educação libertadora, enfatizando a reflexão acerca do sujeito afro-descendente brasileiro. Buscaremos verificar até que ponto esse referencial, como recurso pedagógico, contribui para que o alunado da educação básica possa conhecer melhor sua própria história, produzindo novos conceitos sobre ela e tomando consciência de seu papel de intervenção diante das iniquidades a que se percebe submetido.
O DESENCANTO NA POESIA DE ARMÉNIO VIEIRA
Authors: Souza Larissa , Gomes Simone Caputo
Published: December 2017

A multiplicidade de discussões e referências na poesia do escritor caboverdiano Arménio Vieira traz ao leitor certa desorientação e angústia, como marca da lírica moderna (FRIEDRICH, 1991). Logo, o presente artigo é resultado de nossa angústia e vontade de decifrar os seus códigos discursos, a partir da leitura do livro MITOgrafias (VIEIRA, 2006), em que é possível observar o desencanto como mote para a construção de alguns poemas.
O VOO DA SERPENTE E AS ASAS DA BORBOLETA: SOBRE DOIS POEMAS DE ROBERTO CORRÊA DOS SANTOS
Authors: Amaral Sérgio da Fonseca
Published: December 2017

Ao abordar dois poemas de Roberto Corrêa dos Santos, neste artigo, tenho como propósito analisá-los a partir dos conflitos ali refletidos e pautados por uma construção poética que, ao evocar o sagrado, adentra campos sociais e políticos, operando contra as forças coercitivas e elevando o canto à vida, mesmo vislumbrando momentos limites entre os afetos – que geram vida, que provocam morte.
Exposure to Low-Dose Ionizing Radiation From Cardiac Procedures and Malignancy Risk in Adults With Congenital Heart Disease
Authors: Cohen Sarah , Liu Aihua , Gurvitz Michelle , Guo Liming , Therrien Judith , Laprise Claudie , Kaufman Jay S. , Abrahamowicz Michal , Marelli Ariane J.
Published: December 2017

Background:

Adults with congenital heart disease (CHD) are exposed to increasing amounts of low-dose ionizing radiation (LDIR) from cardiac procedures. Cancer prevalence in this population is higher than in the general population. This study estimates the association between LDIR exposure from cardiac procedures and incident cancer in adult patients with CHD.

Methods:

The study population derived from the Quebec Congenital Heart Disease Database. We measured cumulative numbers of LDIR-related cardiac procedures for each patient until 1 year before the time of cancer diagnosis or administrative censoring. To assess the association between LDIR exposure and cancer risk, we conducted a nested case-control study and matched cancer cases with controls on sex, CHD severity, birth year, and age.

Results:

The study included 24 833 adult patients with CHD aged 18 to 64 years from 1995 to 2009. In >250 791 person-years of follow-up, 602 cancer cases were observed (median age, 55.4 years). The cumulative incidence of cancer estimated up to 64 years of age was 15.3% (95% confidence interval [CI], 14.2–16.5). Cases had more LDIR-related cardiac procedures than controls (1410 versus 921 per 1000 adult patients with CHD,
P
<0.0001). Cumulative LDIR exposure was independently associated with cancer (odds ratio [OR], 1.08 per procedure; 95% CI, 1.04–1.13). Similar results were obtained by using dose estimates for LDIR exposure (OR, 1.10 per 10 mSv; 95% CI, 1.05–1.15) with a possible dose-related response. The effect measure was in the same direction, and the association was persistent for exposure from ≥6 procedures in all sensitivity analyses: after excluding most smoking-related cancer cases (OR, 1.10 per procedure; 95% CI, 1.05–1.16 and OR when exposure from ≥6 procedures, 3.08; 95% CI, 1.77–5.37), and after applying a 3-year lag period (OR, 1.09 per procedure; 95% CI, 1.03–1.14 and OR when exposure from ≥6 procedures: 2.58; 95% CI, 1.43–4.69).

Conclusions:

To our knowledge, this is the first large population-based study to analyze and document the association between LDIR-related cardiac procedures and incident cancer in the population of adults with CHD. Confirmations of these findings by prospective studies are needed to reinforce policy recommendations for radiation surveillance in patients with CHD where no regulation currently exists. Physicians ordering and performing cardiac imaging should ensure that exposure is as low as reasonably achievable without sacrificing quality of care.
Long Noncoding RNA Kcna2 Antisense RNA Contributes to Ventricular Arrhythmias via Silencing Kcna2 in Rats With Congestive Heart Failure
Authors: Long Qing‐Qing , Wang Hao , Gao Wei , Fan Yi , Li Ya‐Fei , Ma Yao , Yang Yang , Shi Hao‐Jie , Chen Bing‐Rui , Meng Hao‐Yu , Wang Qi‐Ming , Wang Fang , Wang Ze‐Mu , Wang Lian‐Sheng
Published: December 2017

Background

Congestive heart failure (
CHF
) is a common cardiovascular disease that is often accompanied by ventricular arrhythmias. The decrease of the slow component of the delayed rectifier potassium current (

I
K

s
) in
CHF
leads to action potential (
AP
) prolongation, and the

I
K

s
is an important contributor to the development of ventricular arrhythmias. However, the molecular mechanisms underlying ventricular arrhythmias are still unknown.

Methods and Results

Kcna2 and Kcna2 antisense RNA (Kcna2
AS)
transcript expression was measured in rat cardiac tissues using quantitative real‐time reverse transcription–polymerase chain reaction and Western blotting. There was a 43% reduction in Kcna2
mRNA
in the left ventricular myocardium of rats with
CHF
. Kcna2 knockdown in the heart decreased the I
Ks
and prolonged
AP
s in cardiomyocytes, consistent with the changes observed in heart failure. Conversely, Kcna2 overexpression in the heart significantly attenuated the
CHF
‐induced decreases in the I
Ks
,
AP
prolongation, and ventricular arrhythmias. Kcna2
AS
was upregulated ≈1.7‐fold in rats with
CHF
and with phenylephrine‐induced cardiomyocyte hypertrophy. Kcna2
AS
inhibition increased the
CHF
‐induced downregulation of Kcna2. Consequently, Kcna2 AS mitigated the decrease in the I
Ks
and the prolongation of
AP
s in vivo and in vitro and reduced ventricular arrhythmias, as detected using electrocardiography.

Conclusions

Ventricular Kcna2
AS
expression increases in rats with
CHF
and contributes to reduced

I
K

s
, prolonged
AP
s, and the occurrence of ventricular arrhythmias by silencing Kcna2. Thus, Kcna2
AS
may be a new target for the prevention and treatment of ventricular arrhythmias in patients with
CHF
.
Prodromus of a fern flora for Bolivia. XXVI. Dennstaedtiaceae
Authors: SCHWARTSBURD PEDRO B. , NAVARRETE HUGO , SMITH ALAN R. , KESSLER MICHAEL
Published: December 2017

We provide a synopsis to the family Dennstaedtiaceae in Bolivia, including 30 species in 7 genera. Two endemic species of Hypolepis, H. periculosa and H. woodii, and a widespread subspecies of Pteridium esculentum, subsp. gryphus, are described as new.
Gene transfer into hematopoietic stem cells reduces HLH manifestations in a murine model of Munc13-4 deficiency
Authors: Soheili Tayebeh , Durand Amandine , Sepulveda Fernando E. , Rivière Julie , Lagresle-Peyrou Chantal , Sadek Hanem , de Saint Basile Geneviève , Martin Samia , Mavilio Fulvio , Cavazzana Marina , André-Schmutz Isabelle
Published: December 2017

Key Points

UNC13D gene transfer into HSCs corrects all clinical and biological signs of HLH in a mouse model. Munc13-4 is expressed in mature CD8+ T cells allowing the correction of cytotoxic activity and consequently efficient viral restriction.
A construção da identidade institucional da regulação bancária brasileira: uma análise à luz da teoria do path dependence
Authors: Jantalia Fabiano
Published: December 2017

The construction of Brazil´s banking regulation institutional identity: an analysis in the light of the path dependence theory O artigo tem por objetivo analisar o processo de construção dos arranjos institucionais da regulação bancária à luz da teoria da dependência de trajetórias (path dependence theory). O autor sustenta que a estrutura institucional vigente, baseada na repartição de competência entre o Conselho Monetário Nacional e o Banco Central do Brasil, é desnecessariamente burocrática e complexa. A partir de uma análise histórico-evolutiva do setor, argumenta-se que fatos antecedentes da história da regulação bancária brasileira acabaram por erigir grandes entraves, restrições e limitações ao processo de definição do aparato institucional de regulação e supervisão bancárias. Aplicando a teoria da dependência de trajetórias, o autor conclui que o modelo institucional vigente de regulação bancária brasileira sofreu, na verdade, um travamento por questões históricas, de modo que sua trajetória de construção acabou marcada pela autorreprodução ou autorreforço das estruturas, o que dificultou a concepção de um arcabouço regulatório mais racional. The article aims to analyze the process of construction of the institutional arrangements of banking regulation in Brazil in the light of path dependence theory. The author argues that the institutional structure in place in Brazil, based on the division of powers between the National Monetary Council and the Central Bank of Brazil, is unnecessarily bureaucratic and complex. From an analysis of history and evolution of the sector, it is argued that facts history of the history of banking regulation in Brazil came to erect high barriers, restrictions and limitations of the process of defining the institutional arrangements for regulating and supervising banks. Applying the theory of dependence of trajectories, the author concludes that the institutional framework of banking regulation in Brazil suffered, in fact, a lock-in by historical events, so that its trajectory of construction was marked by self-reinforcement of structures, making it difficult to design a more rational regulatory framework.
Sub-rogação pelo Fundo Garantidor de Créditos (FGC) em decorrência do pagamento de créditos garantidos
Authors: Salama Bruno Meyerhof
Published: December 2017

.
Effects of a telescopic intramedullary rod for treating patients with osteogenesis imperfecta of the femur
Authors: Rosemberg D. L. , Goiano E. O. , Akkari M. , Santili C.
Published: December 2017

Purpose

To introduce a new model of telescopic intramedullary rod (TIR), evaluate its effects on treating patients presenting with moderate and severe osteogenesis imperfecta (OI) and to compare the findings with those of other telescopic rods.

Methods

A total of 21 patients (nine girls and 12 boys; mean age at first operation, 6.6 years, 1.52 to 13.18) who underwent 52 femoral operations were monitored during a mean of 9.96 years (3.39 to 14.54). Patient characteristics, telescoping rod capability and its complications were examined.

Results

According to the Sillence classification, we investigated one patient with type I, nine with type III and 11 with type IV OI. Revision rates at up to five years (36%) were inferior to those found for the Fassier-Duval rod (46%). The main cause of revision was fracture (15 patients), followed by rod migration (nine), and infection (two). The rod exhibited higher telescopic capacity in boys than girls. Type III most commonly required an operation; the age group with the highest number of procedures was five to ten years. Male migration was the main cause of rod migration.

Conclusion

The TIR has a satisfactory cost-benefit ratio with less complication rates and low production costs. The TIR is a feasible alternative to the commonly used Fassier-Duval rod.

Level of Evidence

IV
Subtalar coalition resection utilizing live navigation: A technique tip
Authors: Stokman J. J. , Mitchell J. , Noonan K.
Published: December 2017

Purpose

Describe the surgical technique of talocalcaneal coalition resection using live CT navigation.

Methods

A ten-year-old female with left talocalcaneal coalition hindfoot pain refractory to conservative management underwent surgical coalition resection using live CT navigation. The procedure and discussion of this technique is described in detail.

Results

With minimal radiation exposure to the patient, CT navigation for this complex talocalcaneal coalition was both helpful and potentially timesaving by allowing immediate localization and guided resection of the coalition.

Conclusion

In the case of a complex subtalar coalition resection, CT navigation poses minimal patient radiation exposure and allows immediate localization and guided resection of the coalition.

Level of Evidence

Level V
A Melhoria da Escola: Linhas Atuais de Investigação
Authors: Bolívar Antonio
Published: December 2017

O artigo realiza uma revisão atual das políticas de melhoria da escola, desde a perspetiva de escola como uma unidade fundamental de mudança e aprendizagem organizacional. Em vez de estratégias verticais ou prescritivas, isto implica formas horizontais de trabalho com as escolas, para que possam construir as suas capacidades de melhoria. Um crescente corpo de pesquisas sugere que a escola requer ser articulada mediante o desenvolvimento de uma liderança pedagógica e uma comunidade profissional. A sustentabilidade da mudança apoia-se na construção de capacidades de toda a escola para promover a aprendizagem profissional.
Profesorado, progenitores y alumnado ante la diversidad sociocultural. Confluencia de perfiles e influencia entre ellos
Authors: Rodríguez Fuentes Antonio
Published: December 2017

El presente trabajo se propone analizar el modelo de Universidad de Oakeshott, partiendo de los supuestos filosóficos que inspiran su teoría educativa general. El análisis pondrá en evidencia la vigencia de algunos de sus aportes y críticas a la educación actual. Al mismo tiempo, indagará respecto de las dificultades fácticas para la aplicación de sus propuestas en el contexto de la educación superior latinoamericana, y propondrá una revisión de la conceptualización misma a partir de la constatación de estas dificultades y a la luz de las orientaciones que el mismo Oakeshott postula en su filosofía educativa.
The Hungarian Revolution of 1956 at Sixty Years, Liberal Reform, and the Search for a Useable Past
Authors: Benziger Karl P
Published: December 2017

The story of the 1956 Hungarian Revolution at sixty years remains contested. The current center-right government led by Prime Minister Viktor Orbán at once embraces the Revolution and yet at the same time trumpets the failure of the liberal states of the West. Hungarians are encouraged to view the authoritarian politics of Vladmir Putin as a successful model worthy of emulation. In this light the liberal state envisioned by many of the revolutionaries, let alone the liberal state expected by the European Union stands in contrast with one of the principal tenets of the ruling FIDESz/Christian Democrat (KDNP) coalition. At the same time, the current yearning for an illiberal state accords with a strand of desire more akin to those who supported Cardinal Mindszenty during the Revolution and by extension his sympathy for the authoritarian regime of Miklós Horthy.
Competência Tradutória
Authors: Liparini Tania , Leipnitz Luciane
Published: December 2017

Este artigo apresenta um recorte do projeto Competência Tradutória e Formação de Tradutores: o desenvolvimento das subcompetências específicas do tradutor (CNPq 485158/2013-2), cujo objetivo é investigar o desenvolvimento da competência tradutória em um grupo de tradutores em formação, a partir de um estudo longitudinal de abordagem processual. Serão discutidos aqui os resultados – obtidos na primeira e segunda etapa do projeto – relativos ao desenvolvimento da subcompetência sobre conhecimentos em tradução. Para a coleta e análise dos dados sobre conhecimentos em tradução, seguimos a metodologia de PACTE (2008). Esses dados foram cruzados com a avaliação da qualidade das traduções, realizada com base nos critérios de PACTE (2011b) e na ferramenta de avaliação Translation Quality Assessment Tool (COLINA, 2008). Os resultados obtidos até o momento apontam para o progresso no desenvolvimento da subcompetência sobre conhecimentos em tradução dos sujeitos, no período compreendido entre a primeira e a segunda etapa da coleta de dados. A pesquisa se encontra em andamento; espera-se, ao final do projeto, além de confirmar os resultados obtidos até o momento, contribuir para ampliar os conhecimentos sobre aquisição da competência tradutória e fomentar reflexões que levem a melhorias no ensino de tradução.
Tecnologias e formação de tradutores
Authors: Stupiello Erika Nogueira de Andrade , Esqueda Marileide Dias
Published: December 2017

Os sistemas de memórias de tradução e as novas aplicações de programas de tradução automática são parte do cotidiano de tradutores que trabalham com traduções especializadas e que prestam serviços para a indústria da localização. A integração dessas tecnologias está promovendo mudanças em muitos cursos universitários de formação de tradutores que, gradativamente, estão revendo seus currículos para incluir o treinamento em ferramentas. Este trabalho relata resultados de dois estudos conduzidos em dois cursos de graduação em tradução em duas universidades públicas brasileiras. Os resultados apontam para a importância de se incluírem, nas aulas de prática de tradução, discussões que estimulem o desenvolvimento de um olhar crítico em relação às ferramentas que os tradutores utilizam, para que aprendam a valorizar seu papel como negociador de sentidos em todo trabalho de tradução.
Urban BaWü-Labs: Challenges and Solutions when Expanding the Real-World Lab Infrastructure
Authors: Schäpke Niko , Stelzer Franziska , Marg Oskar , Bergmann Matthias , Miller Eric , Wagner Felix , Lang Daniel J
Published: December 2017

Urban areas provide space and place for experimentation with sustainability transitions in real-world laboratories. Members of the existing urban laboratories in Baden-Württemberg and experts have discussed the challenges of these innovative research settings, as well as possible
solutions.
A High Efficiency Optical Power Splitter in a Y-Branch Photonic Crystal for DWDM Optical Communication Systems
Authors: Taleb Hesami Azar Milad , Alipour-Banaei Hamed , Zavvari Mahdi
Published: December 2017

In this paper a high efficiency optical power splitter based on two-dimensional photonic crystals is proposed. The photonic crystal cavity is assumed to be constructed by TiO
Combined Multi-Agent Method to Control Inter-Department Common Events Collision for University Courses Timetabling
Authors: Nourmohammadi-Khiarak Jalil , Zamani-Harghalani Yashar , Feizi-Derakhshi Mohammad-Reza
Published: December 2017

University course timetabling is the scheduling of courses at different time slots in a university. The two important issues in this process are (i) the allocation of all events (professors, courses, and students) to resources (time slots daily/weekly and theory/practical classes) in a semester, and (ii) maximizing the satisfaction of common events (professors, courses, and students) among multiple departments. Accumulating evidences in university course timetabling problems suggest dividing the problem into several sub-problems. This study attempted to investigate the appropriateness of using the genetic algorithm (GA) and the imperialist competitive algorithm (ICA). The proposed technique consists of two steps: (i) using the proposed manipulated GA for solving the timetabling problem of each department, and (ii) eliminating the interference of common events among multiple departments and satisfying the hard and soft constraints by using ICA. Finally, a report on the efficiency of the methodology used in this study was obtained from the University of Tabriz in Iran and University of Udine in Italy. In this paper, the results are revealed in two ways: (i) reduction in the problems due to shrinking of the database and solving of the problems in parallel and (ii) solving the different parts of the problem by using various criterion results, increasing the common events satisfaction in that sub-problem. Eventually, the proposed model provided successful satisfaction of the hard constraints in <700 iterations with GA and elimination of interference in 40 iterations with ICA in most of the cases.
Partial androgen insensitivity syndrome due to somatic mosaicism of the androgen receptor
Authors: Batista Rafael Loch , Rodrigues Andresa De Santi , Machado Aline Zamboni , Nishi Mirian Yumie , Cunha Flávia Siqueira , Silva Rosana Barbosa , Costa Elaine M.F. , Mendonca Berenice B. , Domenice Sorahia
Published: December 2017

Background:

Androgen insensitivity syndrome (AIS) is the most frequent etiology of 46,XY disorders of sex development (DSDs), and it is an X-linked disorder caused by mutations in the androgen receptor (AR) gene. AIS patients present a broad phenotypic spectrum and individuals with a partial phenotype present with different degrees of undervirilized external genitalia. There are more than 500 different AR gene allelic variants reported to be linked to AIS, but the presence of somatic mosaicisms has been rarely identified. In the presence of a wild-type AR gene, a significant degree of spontaneous virilization at puberty can be observed, and it could influence the gender assignment, genetic counseling and the clinical and psychological management of these patients and the psychosexual outcomes of these patients are not known.

Case presentation:

In this study, we report two patients with AR allelic variants in heterozygous (c.382G>T and c.1769-1G>C) causing a partial AIS (PAIS) phenotype. The first patient was raised as female and she had undergone a gonadectomy at puberty. In both patients there was congruency between gender of rearing and gender identity and gender role.

Conclusions:

Somatic mosaicism is rare in AIS and nonsense AR variant allelic can cause partial AIS phenotype in this situation. Despite the risk of virilization and prenatal androgen exposure, the gender identity and gender role was concordant with sex of rearing in both cases. A better testosterone response can be expected in male individuals and this should be considered in the clinical management.
Risk factors and classification of stillbirth in a Middle Eastern population: a retrospective study
Authors: Kunjachen Maducolil Mariam , Abid Hafsa , Lobo Rachael Marian , Chughtai Ambreen Qayyum , Afzal Arjumand Muhammad , Saleh Huda Abdullah Hussain , Lindow Stephen W.
Published: December 2017

Objective:

To estimate the incidence of stillbirth, explore the associated maternal and fetal factors and to evaluate the most appropriate classification of stillbirth for a multiethnic population.

Methods:

This is a retrospective population-based study of stillbirth in a large tertiary unit. Data of each stillbirth with a gestational age >/=24 weeks in the year 2015 were collected from electronic medical records and analyzed.

Results:

The stillbirth rate for our multiethnic population is 7.81 per 1000 births. Maternal medical factors comprised 52.4% in which the rates of hypertensive disorders, diabetes and other medical disorders were 22.5%, 20.8% and 8.3%, respectively. The most common fetal factor was intrauterine growth restriction (IUGR) (22.5%) followed by congenital anomalies (21.6%). All cases were categorized using the Wigglesworth, Aberdeen, Tulip, ReCoDe and International Classification of Diseases-perinatal mortality (ICD-PM) classifications and the rates of unclassified stillbirths were 59.2%, 46.6%, 16.6%, 11.6% and 7.5%, respectively. An autopsy was performed in 9.1% of cases reflecting local religious and cultural sensitivities.

Conclusion:

This study highlighted the modifiable risk factors among the Middle Eastern population. The most appropriate classification was the ICD-PM. The low rates of autopsy prevented a detailed evaluation of stillbirths, therefore it is suggested that a minimally invasive autopsy [postmortem magnetic resonance imaging (MRI)] may improve the quality of care.
Maternal and neonatal vitamin D deficiency and transient tachypnea of the newborn in full term neonates
Authors: Omran Ahmed , Mousa Heba , Abdalla Mohamed Osama , Zekry Osama
Published: December 2017

Aim:

To investigate the association between maternal and neonatal serum 25-hydroxyvitamin D (25-OHD) levels and development of transient tachypnea of the newborn (TTN) in full term infants.

Methods:

This was a prospective case-control study carried out on 30 neonates with TTN and their mothers and 30 control neonates and their mothers. Levels of 25-OHD were measured in maternal and neonatal blood samples that were obtained in the first 12–24 h of postnatal age.

Results:

Both maternal and neonatal 25-OHD levels in the TTN group were significantly lower compared to the control group (P=0.0001). A negative correlation was observed between neonatal 25-OHD level and average hospital stay (P=0.0001).

Conclusion:

We observed that lower maternal and neonatal vitamin 25-OHD levels were associated with TTN development in full term infants.
Measurement and uncertainty propagation of the (γ,n) reaction cross-section of 58Ni and 59Co at 15 MeV bremsstrahlung
Authors: Ghosh Reetuparna , Lawriniang Bioletty , Badwar Sylvia , Sheela Yerraguntla Santhi , Naik Haladhara , Patil Bhushankumar J. , Naik Yeshwant , Suryanarayana Saraswatula Venkata , Jyrwa Betylda , Ganesan Srinivasan
Published: December 2017

Activation cross-section of photon-induced reaction on structural materials 58Ni and 59Co was measured at the bremsstrahlung endpoint energy 15 MeV from an S band electron linac. The uncertainties in the (γ,n) reaction cross-section of both 58Ni and 59Co were estimated by using the concept of covariance analysis. The cross-section of 58Ni(γ,n)57Ni reaction in the present work is slightly lower than the previous experimental data and the TENDL-2015 data. The cross-section of 59Co(γ,n)58Co reaction has been measured for the first time. However, the present experimental data of 59Co(γ,n)58Co reaction is very low in comparison to the TENDL-2015 and JENDL/PD-2004 data.
PROAKTİF KİŞİLİĞİN POLİTİK BECERİ ÜZERİNE ETKİSİ
Authors: AKÇAKANAT Tahsin , UZUNBACAK Hasan Hüseyin
Published: December 2017

Bu çalışmanın amacı, üniversitede çalışan idari personelin proaktif kişilik özelliklerinin politik becerileri üzerine olan etkisinin belirlenmesidir. Bu amaç doğrultusunda Claes vd. (2005) tarafından oluşturulup Akın vd. (2011) tarafından Türkçe’ye uyarlanan Proaktif Kişilik Ölçeği ile Ferris vd. (2005) tarafından geliştirilip Atay (2009) tarafından Türkçe’ye uyarlanan Politik Beceri Envanteri uygulanarak personelin proaktif kişilik özellikleri ve politik becerileri arasındaki ilişki korelasyon ve regresyon analizleri yardımıyla saptanmıştır. Sonuç olarak, proaktif kişilik özelliğinin hem genel olarak politik beceriyi hem de alt boyutlarını açıklamada anlamlı bir etkisinin olduğu tespit edilmiştir.
Estrategias de selección y uso de materiales lectores para promover la lectura en educación secundaria
Authors: Luna Peña Ana María , García Oyervides Luis Ricardo , Vázquez Segovia Karen Jazmín , Mancilla Francisco Rocío Elizabeth
Published: December 2017

La labor didáctica de las instituciones educativas ha incluido, desde hace mucho tiempo, el esfuerzo por promover el interés de sus estudiantes en la lectura, pues se sabe que esta les produce múltiples beneficios. Sin embargo, y a pesar de que el discurso de los responsables de la educación argumenta a favor de la promoción del interés y la comprensión durante el acto de leer, los alumnos continúan diciendo que solo leen cuando tienen que hacerlo o que no entienden lo que leen. El presente ensayo pretende mostrar que es posible lograr en los estudiantes de escuela secundaria en México y otros países el interés en la lectura y la comprensión de esta. Además, el ensayo desarrollará una propuesta, con base en una revisión de las teorías pedagógicas y lingüístico-literarias contemporáneas, para promover la lectura a través de un cambio en las estrategias de selección y uso de los materiales de lectura.
Determinaciones categoriales y noción conceptual de la educación: Una lectura crítica en torno al Sistema Interregional Indoeuropeo
Authors: Herra Castro Ernesto
Published: December 2017

Este artículo intenta identificar diversos momentos educativos subsumidos en el conocimiento científico como uno de los muchos saberes humanos con miras a impulsar otros horizontes de sentido que fomenten la producción y reproducción de la vida comunitaria. Se identifican los aportes del saber indoeuropeo y las tensiones existentes a partir de la formalización de sus saberes por la racionalidad helena.
AUTOMATIZACIÓN DE LOS PROCESOS DE SECADO Y SELECCIÓN DEL CACAO ECUATORIANO CONSERVANDO LAS CARACTERÍSTICAS SENSORIALES Y PREVINIENDO RIESGOS LABORALES
Authors: Núñez Solano Sergio Júlio , Moscoso Jácome Ronal Elicio , Rivas Tufiño Alfonso Eduardo
Published: December 2017

El cacao en grano es una fruta tropical considerada como un patrimonio en el Ecuador y que constituye el 60% de la calidad premium en chocolates a nivel mundial, posee características sensoriales inigualables por otros países productores. Las actividades manuales de secado y selección contienen muchos riesgos laborales, afectando la seguridad y el bienestar de las personas que se dedican a estas tareas, siendo el riesgo ergonómico de nivel intolerable y que requiere intervención inmediata. Esta investigación proporciona mecanismos automatizados seguros para las operaciones a través de metodologías validadas internacionalmente, sin afectar las características sensoriales del cacao ecuatoriano.
Esquemas disfuncionales tempranos y consumo de alcohol en estudiantes universitarios, según carrera profesional de una universidad pública de la ciudad de Lima
Authors: Huerta R. Rosa E. , Miljanovich Manuel , Aliaga Jaime , Campos Emma , Ramírez Natalia , Delgado Eliana , Ramos Jessica , Murillo Lourdes
Published: December 2017

En el estudio se sometió al análisis las variables esquemas cognitivos disfuncionales tempranos y consumo de alcohol según carrera profesional, ciencias de la salud e ingeniería en una muestra de 510 estudiantes universitarios, a quienes se les administró una ficha de datos sociodemográficos, el Cuestionario de Esquemas de Young integrado por 18 esquemas y el Cuestionario de Identificación de los Trastornos debidos al Consumo de Alcohol (AUDIT). Se encontró que existe una correlación significativa y positiva entre los esquemas disfuncionales tempranos, privación emocional, grandiosidad insuficiente autocontrol y reconocimiento con el consumo de alcohol, En ciencias de la salud en el grupo de consumo de riesgo predomina el esquema autosacrificio y en ingeniería los esquemas dependencia /incompetencia y subyugación. Los estudiantes con consumo de riesgo más alto son de ingeniería (31) en comparación con los de ciencias de la salud que fue menor (7). Los estudiantes de ingeniería presentan mayor consumo de alcohol. Resultados que son graves pues el consumo de alcohol se asocia con esquemas cognitivos caracterizados por la sobreestimación al daño, baja tolerancia a la frustración y alta necesidad de aprobación social.
Sexual Violence, Religion and Women’s Rights in Global Perspective
Authors: Toit Louise du
Published: December 2017

This article cautions against spectacularizing the sexual violence that takes place in non-Western places, without proper contextualization. I suggest that the inertia in local African churches and communities against taking a stronger stand against the perpetrators of sexual violence, should be read against the global backdrop. This larger context contains, inter alia, western economic interests that contribute to destabilize African states, a globally dominant liberal legal order which in its turn also fails to address sexual violence, and African and western patriarchies that collude against women. Thus, if the influential African Christian Churches are to stand up against sexual violence against women, they face not only the likely resistance of church leadership and local patriarchies, but on a higher level also the resistance of international economic and patriarchal powers covertly in cahoots with local male elites.
Integracja europejska w obliczu eurosceptycyzmu
Authors: Pleśniarska Aleksandra
Published: December 2017

Eurosceptical views are more and more often evident in the programmes and activities of European political parties, and are manifested in the political debate transpiring in Member States. Is Euroscepticism an opportunity or a threat for the future of the idea of European integration? Does it threaten the cohesion of the European project? The main aim of this article is to answer these questions.Euroscepticism and the categorizations it breaks down into are defined in the article. Empirical analysis and a review of the literature are used to illustrate the importance of Eurosceptics in the European Parliament. This study identifies why Eurosceptical views in Europe have become more popular, pointing to the existence of many European crises, including in the economy, migration and democracy.The number of Eurosceptics in the EP has increased, but they come from different political groups. If their opinions are to be seen as an opportunity for the future of the EU, their demands must be consolidated and infused with greater coherence. Eurosceptical views should not be marginalized in the context of the further development of the EU.
Realizacja celów polityki klimatyczno-energetycznej Unii Europejskiej w kontekście polityki energetycznej w wybranych państwach członkowskich
Authors: Zajączkowska Magdalena
Published: December 2017

The main aim of this article is to present the results of the analysis of the EU climate and energy policy goals in selected Member States in the context of their energy policies. The analysis covers the period 2008–2014 and focuses on seven EU Member States: the Czech Republic, Denmark, Germany, France, Lithuania, Poland and the United Kingdom. Each of the countries is implementing EU climate and energy policy goals, but to varying degrees. The research leads to the conclusion that more and more countries implement energy policy primarily based on national policy, which is not always consistent with the assumptions of the EU’s policy.
Evaluation of the Genetic Variation of Cowpea Landraces (Vigna unguiculata) from Western Cameroon Using Qualitative Traits
Authors: NGOMPE-DEFFO Toscani , KOUAM Eric Bertrand , BEYEGUE-DJONKO Honoré , ANOUMAA Mariette
Published: December 2017

Characterization of the genetic diversity and analysis of the genetic relationship between accessions of a crop species is a key step in breeding superior cultivars. The main objective of the hereby study was to determine the genetic variation between 30 cowpea accessions collected throughout the eight divisions of the Western Region of Cameroon using qualitative traits. Phenotypic variation of these accessions was evaluated using diversity indices and cluster analyses. A total of twenty qualitative traits were used for the study. Fifteen of them (75%) were polymorphic, displaying each at least two phenotypic classes. The monomorphic characters were growth pattern, leaf color, leaf hairiness, plant hairiness and pod hairiness, each with only one phenotypic class. Results showed a relatively significant level of genetic diversity among the studied cowpea accessions. Overall, the average of the observed and effective number of phenotypic classes per qualitative trait were Na = 2.350 and Ne = 1.828 respectively. The Nei’s genetic diversity and the Shannon weaver diversity index were He = 0.369, ranging from zero (monomorphic trait) to 0.655 (growth habit) and H’ = 0.609, ranging from zero (monomorphic trait) to 0.996 (seed crowding), respectively. The dendrogram constructed from the twenty qualitative traits revealed 05 accessions clusters with the number of accessions in each cluster varying from one to eleven. Information obtained from this study is likely be useful for future cowpea breeding program.
Can renal stone size and the use of the nephrolithometric system increase the efficacy of predicting the risk of failure of percutaneous nephrolithotripsy?
Authors: FELICI EDUARDO MEDINA , DINIZ ANDRÉ LUIZ LIMA , SOUZA TOMAS ACCIOLY , FAVORITO LUCIANO ALVES , RESENDE JÚNIOR JOSÉ ANACLETO DUTRA
Published: December 2017

ABSTRACT Objective : to verify the association of success rate of percutaneous lithotripsy, Guy score and size of the stone. Methods: one hundred patients submitted to percutaneous nephrolithotripsy were evaluated. All stones were classified according to Guy Score. Patient free of stone was considered when residual fragments were ≤2mm. Results: according to guy Score, 54% were score 1 (Group 1), 18% score 2 (Group 2), 15% score 3 (Group 3), and 13% score 4 (Group 4). Success was observed in 77.77% in Group 1, 27.77% in group 2, 26.6% in Group 3, and 7.69% in Group 4. In patients with Guy score 1, there was statistical significance of prediction of free stone rate when evaluated according to the size of the stone. Among groups 2, 3 and 4 there was no statistical significance, but it was observed a trend in relation to stone size, the bigger the higher the chance of residual fragments. Conclusion: nephrolithometry by Guy Score and size of the stone are single predictors of success of percutaneous nephrolithotripsy. Stone size may influence success rate of patients with Guy Score 1.