bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of a Long-Range Dislocation Pileup on the Atomic-Scale Hydrogen Diffusion near a Grain Boundary in Plastically Deformed BCC Iron
Authors: Peng Yipeng , Ji Rigelesaiyin , Phan Thanh , Chen Xiang (Shawn) , Zhang Ning , Xu Shuozhi , Bastawros Ashraf F. , Xiong Liming
Published: July 2023

The microstructure of oil pipeline steels is polycrystalline due to the presence of a complex grain boundary (GB) network in them. The performance of them when exposed to stresses in corrosive environments is largely dictated by the interplay between the hydrogen (H) diffusion, the dislocation slip, and their interactions with the GBs. However, the slip-GB interaction in the presence of H and the subsequent cracking along the GBs remains not fully understood up to date. It is challenging to simultaneously resolve the collective dislocation motions away from the GBs together with the H diffusion near the atomically structured GBs using single-scale techniques. To address this challenge, taking bcc iron as a model material, here we present a a concurrent atomistic-continuum (CAC) computational analysis of the interaction between dislocation slip and a H-charged GB. With the large number of dislocations-mediated plastic flow away from the GB together with the atomistic structure evolution at the GB being simultaneously retained, several main findings from our simulations are: (i) the large number of dislocation-mediated pileup-induced internal stress nearby the H-charged GB can be as high as 3GPa; (ii) the more dislocations accumulated nearby the GB, the slower H diffusion ahead of the slip-GB intersection; (iii) H atoms diffuse fast behind the pileup tip, get trapped within the GB, and diffuse slow ahead of the pileup tip; (iv) the local stresses nearby the pileup tip exhibits a strong heterogeneity along the dislocation line direction. This differs from the common wisdom in many existing 2D theories/models. The buildup of such a high local stress heterogeneity leads to inhomogeneous H diffusion within the GB plane. The CAC simulation-predicted local H diffusivity, Dpileup−tip, and local stresses, σ, nearby the GB are then correlated with each other and consolidated into a mechanics model by considering the dislocation pileup as an Eshelby inclusion. These findings will provide researchers with opportunities to: (a) characterize the coupled dynamics between plasticity, H diffusion, and crack initiation underlying the hydrogen-induced cracking (HIC); (b) develop mechanism-based constitutive rules to be used in diffusion-plasticity coupling models for understanding the interplay between mechanical and mass transport in materials at the continuum level; and (c) connect the atomistic deformation physics of polycrystalline materials with their overall performance in aqueous environments, which is currently difficult to achieve in laboratory experiments.
Towards a Value-Based Therapy Recommendation Model
Authors: Liu Zhang , Xiao Liang
Published: July 2023

Patient value is an important factor in clinical decision-making, but conventionally, it is not incorporated in the decision processes. In this paper, a value-based therapy recommendation comprehensive model is proposed. A literature analysis is conducted to collect value-based evidence. Categorized values and candidate therapies are used in combination as filtering keywords to build this evidence. Then a formalism model is put forward to integrate the value-based evidence with clinical evidence. The relative importance of two evidence can be adjusted dynamically by decision-makers during the decision-making processes. A prototype system was implemented using a case study for breast cancer and validated for feasibility and effectiveness.
Iterative List Patterned Reed-Muller Projection Detection-based Packetized Unsourced Massive Random Access
Authors: Xie Wenjiao , Tian Runhe , Zhang Huisheng
Published: July 2023

We consider a coded compressed sensing protocol for unsourced massive random access (URA) that concatenates a shared Patterned Reed-Muller (PRM) inner codebook to an outer error-correction code. In this paper, an iterative list PRM projection algorithm is proposed to supplant the signal detector associated with the inner PRM sequences. In particular, we first propose an enhanced paths-saving algorithm called list PRM projection detection for the single-user scenario that keeps multiple candidates for the first few layers to remedy the risk of spreading errors. On this basis, we further propose an iterative list PRM projection algorithm for the multi-user scenario. The vectors for PRM codes and channel coefficients are jointly detected in an iterative manner, which offers significant improvements regarding the convergence rate for signal recovery. Furthermore, the performances of the proposed algorithms are analyzed mathematically, and we verified that the theoretical simulations are consistent with the numerical simulations. Finally, we concatenate the inner PRM codes that employ the iterative list detection to two practical error-correction outer codes. According to the simulation results, we conclude that the packetized URA with the proposed iterative list projection detection works better than benchmarks in terms of the number of active users it can support in each slot and the amount of energy needed per bit to meet an expected error probability.
The Problem of Rural Depopulation in Spain. Towards a Sustainable, Person-Centred Model of Repopulation
Authors: Osorio García de Oteyza Miguel , Gutierrez Sanchis Ana , Conde Lopez Jorge
Published: July 2023

For the first time in human history the majority of people no longer live in a rural environment. According to the United Nations, over 50% of the global population now lives in cities.
The abandonment of the rural environment has grave consequences for society in general, as these areas are healthier places to live, produce the food we all depend on, and are an important factor for preserving biodiversity and environmental sustainability.
In this paper we will provide a historical overview of rural repopulation models and analyse a number of models currently being applied in several countries in Europe and Latin America. We will also offer observations on a pilot repopulation project called “Habita Tierra” currently being developed.
The common characteristics of different repopulation models prompted us to develop a model based on active listening and accompaniment of people and local agents as well as other important factors.
Rural depopulation in Spain involves a number of interrelated problems, one of the most salient being the aging rural population. The average farmer in Spain is 61 years of age. There is also the problem of gender imbalance in rural areas, where women enjoy few opportunities or alternatives. In turn, low fertility rates, increasing stress on limited public healthcare, education and transpor-tation resources, a lack of cultural activities and poor connectivity are also factors driving rural depopulation.
The only group which is increasing the rural areas in Spain are immigrants, who now account for 10% of the rural population, often performing the agricultural, fishing and livestock farming ac-tivities abandoned by native residents. This group, along with young people, and women of all ages and the programs which support them may offer a solution to the challenge of depopulation.
The paper concludes with a list of the key features of successful repopulation programs, drawn from a comparison of historic and contemporary models.
Design Considerations on Semi-submersible Columns and Pontoons for Floating Wind
Authors: Ivanov Glib , Hsu I Jen , Ma Kai-Tung
Published: July 2023

Floating Offshore Wind Turbine (FOWT) is an innovative technology with little industry guidance for its hull design. Various FOWT floaters with different hull shapes claim to support the same turbines. Structural integrity and material expense analyses of different pontoon shapes were conducted, and it was found that some configurations, such as those with every two columns connected by both pontoon and bracing, have advantages over others. However, it is important to note that the choice of pontoon shape should be based on the wave loading conditions the floater will be exposed to. While a T-shaped pontoon provides a cost-effective solution under certain wave loading scenarios, it may not be the best option for all conditions. Specifically, ring pontoon designs with full bracing were found to be necessary for withstanding certain wave loads. Therefore, it is important to consider different Dominant Load Parameters (DLP) and ensure that a FOWT floater can withstand all applicable DLPs. An uneven hexahedral column shape, which combines the best attributes of square and round shapes, is proposed as a better alternative to cylindrical columns. It offers ease of manufacture and reasonably low drag. Bracing is found to be necessary for withstanding the wind turbine’s incurred moment and forces. The conclusion is that platform design should prioritize manufacturing costs and strength over maximizing hydrodynamic performance.
Application of Self-Potential Method in Mapping Leachate Flow Around Rasau Jaya Landfills, Kubu Raya Regency
Authors: Kaharudin Kaharudin , Arman Yudha , Muhardi Muhardi
Published: July 2023

This study uses the self-potential method to map the leachate flow around the Rasau Jaya landfill, Sungai Raya District, Kubu Raya Regency. The study was carried out in 2 areas, the north and south of the landfill. Data acquisition using a fixed base configuration by applying ten lines. Each line has a length of 105 m with 5 m, and the distance between the porous pots is 5 m. The measurement results show that the potential value distribution at the first location is -19.62 mV to 8.44 mV, and the potential value at the second location is -55.50 mV to 23.26 mV. The interpretation shows that leachate accumulation from the landfill in the first area has a potential value of -19.62 mV to -13 mV. The second location has a potential value of -55.50 mV to -36 mV. Based on isopotential contour maps, leachate accumulation in the first location is thought to be in the north to northeast of the landfill, while in the second location, it is thought to be in the southwest to the west of the landfill.
Effect of pH and Surfactant Concentration Sodium Lignosulfonate (SLS) towards Reduction of Silica Mass from Geothermal Brine
Authors: Ulya M. Ridho , Suharmanto Suharmanto , Saaduddin Saaduddin , Supriyadi Didik
Published: July 2023

Geothermal energy source is one of the wealth of mineral resources that are being widely used. Geothermal Power Plant is a solution to the needs of New Renewable Energy to overcome energy needs and dependence on renewable energy. However, there were important problems that occurred in the geothermal field, namely the formation of silica scaling in the production pipe causing the brine injection process to be disrupted, the injection process aims to maintain the volume of the geothermal reservoir and maintain the quantity of production steam in the long run. Therefore, controlling silica in the brine injection path in geothermal fields is very much needed. This paper discussed the decrease in silica mass influenced by pH and the addition of Sodium Lignosulfonate (SLS) surfactants that studying the changes in pH (7, 8 and 9), and surfactant concentrations (0.05, 0.15 and 0.30% (w/v)). The results showed that the dissolved silica in the geothermal solution was reduced and could be controlled by the addition of SLS surfactants. The greater the surfactant concentration and pH, the more the mass of silica will be taken. The best conditions are at pH 9 and SLS surfactant concentration 0.30%w/v.
Ulinastatin Improves Endothelial Cells Injury, Attenuating Cardiac Ischemia/Reperfusion Injury via Suppressing Tissue kallikrein-kinin System Activation
Authors: Ran Xiao , Ruan Hang , Li Shu-sheng , Luo Ailin , Zhang Qin
Published: July 2023

Background: Ulinastatin (UIT) has been considered to have beneficial effects for patients undergoing coronary artery bypass grafting (CABG) surgery due to its anti-inflammatory properties, whereas the underlying mechanism remains unclear.Approach and Results:We established an interlink among UIT, the kallikrein-kinin system (KKS), endothelial dysfunction and cardiac inflammation in response to ischemia/reperfusion injury (IRI), using clinic investigation, in vitro and in vivo experiments, and RNA sequencing analysis. UIT was observed to inhibit the activity of tissue kallikrein (KLK1), a key enzyme of the KKS, at 24 hours after CABG surgery, which was verified in a mouse cardiac ischemia-reperfusion (I/R) model. Under normal conditions, UTI only inhibited KLK1 activity but did not affect bradykinin receptors (Bdkrs). Ourin vitroandin vivoexperiments revealed that UTI protected against IRI by suppressing the activation of KKS and down-regulating Bdkr-related signaling pathways including extracellular-signal–regulated kinase (ERK)/inducible nitric oxide synthase (iNOS) , which resulted in enhanced endothelial barrier function, mitigation of inflammation and edema, diminution of infarct size, ameliorated cardiac function, and decreased mortality. Inhibition of KLK1 and knockdown of bradykinin receptor 1 (Bdkrb1) not bradykinin receptor 2 (Bdkrb2) significantly prevented ERK translocation into the nucleus, reducing reperfusion-induced mouse cardiac endothelial cells (MCECs) injury.Conclusion:Our findings imply that UIT exerts a protective effect on cardiac reperfusion by suppressing the activation of KKS and highlightsthat inhibiting KLK1/Bdkrb1 is a potential intervention targeting endothelial dysfunction to ameliorate cardiac IRI.
Single-cell RNA-seq reveals keratinocytes and fibroblasts heterogeneity and their crosstalk via epithelial-mesenchymal transition in psoriasis
Authors: Dang Ningning , Guo Dianhao , Li Xiaokang , Wang Jing , Liu Xin , Huang Shuhong
Published: July 2023

As a chronic inflammatory autoimmune skin disease with high global prevalence, the pathogenesis of psoriasis remains inconclusive. We performed a high-resolution single-cell RNA sequencing analysis of 94 759 cells from 13 samples including psoriasis and wide-type mouse model. We presented a comprehensive single-cell transcriptional landscape of the skin immune cells in psoriasis, especially the heterogeneity of keratinocytes and fibroblasts. More interestingly, we discovered that special keratinocyte subtypes and fibroblast subtypes could interact with each other through epithelial–mesenchymal transition and validated the results with drug verification. What’s more, we conducted a tentative exploration of the potential involving pathway and disclosed that the IL-17 signaling pathway may be the most relevant one. Collectively, we revealed the full-cycle landscape of key cells associated with psoriasis and provided a more comprehensive understanding of the pathogenesis of psoriasis.
A Systematic Technique for Kinetic Parameter Estimation in Heterogeneous Solid Catalytic Reaction Networks with Applications
Authors: Fernandes Thalita , Silva Sidinei , Araújo Antonio
Published: July 2023

Estimating kinetic parameters in heterogeneous solid catalytic reaction networks is known to being a difficult task. This work aims at proposing a down-to-earth methodology to obtain kinetic parameters from numerical experiments. We present three techniques: a multivariable linear regression model, a stochastic metamodeling, and an optimized Kriging interpolator connected to a least-squares method. We consolidate the methodology in two different applications. The first one is a process with few components in two reactions from where it was possible to acquire the reaction rate equations that fitted literature data. The second one is a complex industrial reaction network. The results showed that even if the candidate proposed reaction rate equations do not fit the experiments, it is possible to construct a mathematical metamodel that conforms to the behavior of the components. Statistical tests showed that in both cases the proposed models successfully fit the experimental data.
Forecasting Informal Care Needs of the Urban-Rural Older Adults in China Based on Multi-state Markov Model
Authors: Fang Ya , Zhang Liangwen , Shen Shuyuan , Zhang Wenzheng
Published: July 2023

Background
Forecasting the intensity, source, and cost of informal care for older adults in China is essential to establish and enhance policy support systems for informal care within the context of East Asian traditional culture that emphasizes filial piety. This study aims to analyze the current situation and influencing factors for the informal care needs and predict the trends of informal care needs for older adults in China from 2020 to 2040.
Methods
Using the CHARLS database from 2015 to 2018, this study first combined the literature analysis method, a two-part model, and a multinomial logit to analyze the aging trend, population size, and influencing factors for the informal care needs of urban-rural older adults in China. Secondly, a multi-state Markov model was constructed to forecast the number of urban-rural older populations in each health state from 2020 to 2040. Finally, based on a microsimulation model, this study predicted the trends of informal care intensity, source, and cost for older adults in urban and rural areas from 2020 to 2040.
Results
In 2040, the size of the disabled older population in China will expand further. In rural areas, the total number of disabled people in 2040 (39.77 million) is 1.50 times higher than that in 2020; In urban areas, the total number of disabled people in 2040 (56.01 million) is 2.51 times higher than that in 2020. Compared with 2020, the elderly population with mild, moderate and severe disability in 2040 would increase by 87.60%, 101.70%, and 115.08%, respectively. In 2040, the number of older adults receiving low-, medium-, and high-intensity care in China will be 38.60 million, 22.89 million, and 41.69 million, respectively, and older people will still rely on informal care provided by spouses and children (from spouses only: 39.26 million, from children only: 36.74 million, from spouses and children only: 16.79 million, other: 10.39 million). The total cost of informal care in 2040 will be 1,086.65 billion yuan, 2.22 times that of 2020 (490.31 billion yuan), which grows faster than the economic growth rate.
Conclusion
From 2020 to 2040, the informal care needs of older people in rural areas will increase first and then decrease due to the demographic structure and rapid urbanization. In contrast, the informal care needs of older people in urban areas will continuously increase from 2020 to 2040, with the growth rate gradually slowing down. This study provides an evidence-based rationale for scientifically measuring the economic value of informal care and reasonably allocating care resources.
Combination of engineered FnCas9 and extended gRNAs for PAM-flexible, robust and nucleobase specific editing and diagnostics
Authors: Chakraborty Debojyoti , Acharya Sundaram , Ansari Asgar , Hirano Seiichi , Sarkar Sajal , Rauthan Riya , Kumar Manoj , Phutela Rhythm , Gulati Sneha , Afzal C , Paul Deepanjan , Rahman Abdul , Mahato Sudipta , Maddileti Savitri , Pulimamidi Vinay , Jalali Subhadra , Nishimasu Hiroshi , Mariappan Indumathi , Nureki Osamu , Maiti Souvik
Published: July 2023

The clinical success of CRISPR therapies is dependent on the safety and efficacy of Cas proteins. The Cas9 from Francisella novicida (FnCas9) has negligible affinity for mismatched substrates enabling it to discriminate off-targets in DNA with very high precision even at the level of binding. However, its cellular targeting efficiency is low, limiting its use in therapeutic applications. Here, we rationally engineer the protein to develop enhanced FnCas9 (enFnCas9) variants and expand its cellular editing activity to genomic loci previously inaccessible. Notably, some of the variants release the protospacer adjacent motif (PAM) constraint from NGG to NGR/NRG increasing their accessibility across human genomic sites by ~ 3.5-fold. The enFnCas9 proteins harbor single mismatch specificity both in vitro and in cellulo leading to broadened target range of FnCas9-based CRISPR diagnostics for detection of point mutations and pathogenic DNA signatures. Importantly, they provide superior outcomes in terms of editing efficiency, knock-in rates and off-target specificity over other engineered high-fidelity versions of SpCas9 (SpCas9-HF1 and eSpCas9). Remarkably, enFnCas9 variants can be combined with extended length gRNAs for robust base editing at sites which are inaccessible to PAM-constrained canonical base editors. Finally, we show the complete correction of a disease-specific Retinitis Pigmentosa mutation in patient derived iPSCs using enFnCas9 Adenine Base Editor highlighting its broad application in therapeutics and diagnostics.
ENAGRINEWS:An English News Dataset for Agriculture
Authors: Drury Brett , Adelowo Omobolaji
Published: July 2023

Text mining in agriculture is still lagging behind its application in other domains such as bio-medicine and finance. This might be due to the limited availability of freely available agricultural corpora. To address this issue, a new corpus called ENAGRINEWS has been introduced. The corpus consists of 22,814 agricultural-related documents collected from news sites and blogs between 2020 and 2022 from various agricultural sources and includes 10,999 unique AGROVOC annotations and 12,100 unique entities, with 7,998 of them having PermID URI. The aim of releasing this corpus is to promote and encourage research in Agricultural Text Mining.
Collective mapping of gas leaks to determine safe routes through multi-robot system with scalable sizes
Authors: Rohrich Ronnier Frates , Messias Luis Felipe , Lima Jose , de Oliveira André Schneider
Published: July 2023

This article discusses a novel approach to collective mapping that usesautonomous sensors to create safe routes in environments with gas leaks. The useof multiple mobile sensors seek to delimit different regions and assign them dif-ferent tasks according to their momentary needs. This collective approach aimsto optimize the routes to a gas source, offering safer alternatives for access toand from the environment. The sharing of information between sensors is essen-tial so that the mapping and optimization of safe routes are always balanced,with respect to the different functions of the mobile sensors. In this study, robotgroups act as multiple composite sensors that can move independently accordingto the functions assigned to them. Autonomous detection, collective mapping,and collective decision-making of the robots are behaviors bioinspired from thecognitive mechanisms observed in bacterial colonies. These colonies continuouslyseek to maintain the lives of their species based on their collective decision-making in searching for energy sources and changing colony size. Furthermore, although the sensors have a collective memory in all tasks, each sensor has anautonomous behavior of searching for gas leaks, during initial measurements. Inaddition, as gas dispersion in the environment increases, the received data fromthe sensors aids collective decision- making, assigning different functions, such asmapping, environment exploration, and routes creation, to groups of mobile sen-sors. Depending on the momentary need, the number of sensors in each groupchanges. The proposed method in this study was based on real mobile robots withcharacteristics that enable varying levels of scalability in size. Subsequently, itwas evaluated in a simulated system and developed for experimentation with gasand mobile sensors in a dynamic and realistic environment. Several experimentswere also designed to elucidate the collective contributions of mapping and creat-ing safe routes in environments subject to gas leakage. In addition to presentingthe agreement between the multiple mobile sensors, this study further contributesto the analysis of multiple tasks in homogeneous sensor groups in executing dif-ferent tasks. Furthermore, this work introduced a simulated experimental systemto test different topologies of multiple mobile sensors.
The synergy between deep learning and numerical modeling in estimating NOx emissions at a fine spatiotemporal resolution
Authors: Jung Jia , Choi Yunsoo , Ghahremanloo Masoud , Lops Yannic , Momeni Mahmoudreza , Feng Sha , Pan Shuai , Jeon Wonbae , Yoo Jung-Woo
Published: July 2023

This study focused on the remarkable applicability of deep learning (DL) together with numerical modeling in estimating NOx emissions at a fine spatiotemporal resolution during the summer of 2017 over the contiguous United States (CONUS). We employed the partial convolutional neural network (PCNN) and the deep neural network (DNN) to fill gaps in the OMI tropospheric NO2 column and estimate the daily proxy surface NO2 map at a spatial resolution of 10 km × 10 km, showing high capability with strong correspondence (R: 0.92, IOA: 0.96, MAE: 1.43). Subsequently, we conducted an inversion of NOx emissions using the Community Multiscale Air Quality (CMAQ) model at 12 km grid spacing to gain a comprehensive understanding of the chemical evolution. Compared to the prior emissions, the inversion indicated higher NOx emissions over CONUS (3.21 ± 3.34 times), effectively mitigating the underestimation of surface NO2 concentrations with the prior emissions. Incorporating the DL-estimated daily proxy surface NO2 map yielded primary benefits, reducing bias (-1.53 ppb to 0.26 ppb) and enhancing day-to-day variability with higher correspondence (0.84 to 0.92) and lower error (0.48 ppb to 0.10 ppb) across CONUS.
In-situ measurements reveal significant differences in energy and mass-balance components on monsoon- and westerlies-dominated glaciers in High Mountain Asia
Authors: Wang Puyu , Li Hongliang , Li Zhongqin , Wang Feiteng , Jin Shuang , Zhao Weibo , Yu Fengchen , He Jie
Published: July 2023

Physical interactions between glacier surfaces and atmosphere are crucial to understanding the mechanism and process of glacier ablation but poorly constrained based on measured meteorological data from monitoring glaciers. We investigate how climatic regimes influence glacier mass loss in High Mountain Asia (HMA) from the perspective of glacier energy and mass balance for 30 glaciers with meteorological and mass-balance observations and project their volume loss under various shared socioeconomic pathways (SSPs) by the end of the 21st century. Our study shows that net shortwave (SWnet; 92.7%) and longwave (LWnet; 82.0%) radiation in the monsoon-dominated glaciers during the melt season are 1.08 times higher than those in the westerlies-dominated glaciers. Turbulent fluxes are similar in both regions, so that SWnet and LWnet determine the energy supply and expenditure in the two regions, respectively. Driven by such an energy balance context, melt (94.3%) in monsoon-dominated glaciers is 1.38 times greater than in westerlies-dominated glaciers, while snowfall in monsoon-dominated glaciers decreases, which jointly determines the difference in mass loss between the two regions. Additionally, sublimation and refreezing are the crucial factors contributing to mass balance, but their impact on mass balance is small. Volume-loss differences of approximately 15% also exist between the two regions under three shared socioeconomic pathways (SSPs).
Conversion of waste animal bones to biofertilizer and adsorbent for wastewater treatment: An innovative approach to develop zero-waste technology
Authors: Khan Abdul Majeed , Usmani Muhammad Arsalan , Yasmeen Kousar , Ahmed Muhammad Naeem , Obaid Muhammad , Naz Sehar Afshan , Pervaiz Sobia , Chan Malik Wajid Hussain , Khan Ali , Aslam Sardar
Published: July 2023

Presently a number of chemical fertilizers are being used which are not only expensive but are also environment threatening. There is a need to replace these fertilizers by biofertilizers. Adsorbent were prepared from waste bones for the waste water treatment. Various bone samples were collected and calcinated to produce biofertilizer and adsorbent. Total carbon (TC) and total nitrogen (TN) were analyzed. The broiler chicken bone-based biofertilizer has the lowest amount of TC and TN (TC = 33 and TN = 5.5 g/Kg) and also the lowest macro-elements; Ca = 55, P = 26, K = 2.5, and Mg = 0.83 g/Kg. All samples were used for the growth of kidney bean plant. After 5 weeks, the highest growth was observed for buffalo bone-based fertilizer and the lowest for broiler bone-based fertilizer. In the present study, the calcinated bones material was also used as nano-adsorbent for the removal of heavy metals from the artificial wastewater. All nano-adsorbent samples showed maximum efficiency at 100 ppm, while maximum removal was at 6 h. The highest removal efficiency was obtained for buffalo bone-based nano-adsorbent (As = 60% and Pb = 75%), and the lowest removal efficiency was obtained for broiler bone-based nano-adsorbent (As = 36% and Pb = 47%). The calcinated animal bones were analyzed using Flame Atomic Absorption Spectrophotometry (FAAS), Fourier Transform Infrared Spectroscopy (FTIR), chemical tests and antimicrobial susceptibility test (AST). This research can play an important role for the promotion of agricultural crops and for wastewater treatment using nano-technology.
Development of a Neonatal Cardiac Curriculum for Neonatal-Perinatal Fellowship Training
Authors: Sen Shawn , Patel Shivani , Koenig Peter , Myers Patrick
Published: July 2023

Background
The topic of neonatal cardiovascular care in neonatal-perinatal fellowship training has continued to transform due to the increased complexity of patients, the development of specialized units, continued ACGME educational requirements, and clinical practice variation across centers that care for neonates with congenital heart disease.
Methods
We developed a formal neonatal cardiac curriculum, comprised of eight interactive sessions, with novel active learning concepts specific to our neonatal-perinatal fellows that were presented annually.
Results
There was an overall 10-point increase in the comfort level in managing infants with congenital heart disease among neonatal fellows. The average American Board of Pediatrics Subspecialty In-Training Exam scores improved from baseline in all years of the intervention.
Conclusion
Due to the variable clinical exposure and differing practice models of congenital heart disease a formal neonatal cardiac curriculum may be beneficial to neonatal-perinatal trainees.
New contribution to the biostratigraphy of Naopurdan limestone unit (Eocene), Bulfat area, Sulaimaniyah, Kurdistan Region, NE Iraq
Authors: Ghafor Imad , Muhammad Hemn F.
Published: July 2023

Forty- nine samples were collected for a biostratigraphic study of the Naouprdan limestone unit to determine the age of its strata. The studied section is located within the Zagros High Fold and Thrust Belt. The lithology of the succession here is composed of grey fine-grain of limestone withNummulitesandAlveoloina,the whole section is highly deformed and fractured. Hence, for the first time, this limestone unit describes in detail; it is a 48m bed of grey fine-grain, Alveolinidae-Nummulitidae limestone. It bears a frequent number of large benthic foraminifera that are concentrated within the limestone bed. It is detected within the Naopurdan succession from the Bulfat area, Sulaimaniyah, Kurdistan Region/northeastern Iraq. The identified-benthic foraminifera is of the groups: Nummulitidae; Alveolinidae; Acervulinidae; Acervulinidae; Rotaliidae; Linderinidae; Linderinidae; Hauerinidae; Textulariidae; Textulariidae. A detailed study of the benthic foraminiferal assemblages of the limestone unit revealed the occurrences of (104) species of benthic foraminifera belonging to (11) genera. The stratigraphic distribution of these species permits the recognition of four biozones. These are from the lower to upper part of the section:Alveolina oblonga-Nummulites djokdjokartaeInterval Zone,Nummulites djokdjokartaeTotal Range Zone,Nummulites fabianiTotal Range Zone, andAlveolina leupoldi-Alveolina ellipticaInterval Zone. This study demonstrates that the lithology of this limestone bed is equivalent to the Nummulitic Naopurdan group of the Zagros Low Fold and Thrust Belt since they have similar lithology and fossil contents. This section has not previously been described.
High Dose of Metformin Decreases Susceptibility to Occlusive Arterial Thrombosis in Diabetic Mice
Authors: Alvidrez Roberto I. Mota , Annarapu Gowtham K. , Sriniv Amudan J. , Liu Zeyu , Yazdani Hamza O. , Simmons Richard L. , Shiva Sruti , Neal Matthew D. , Nolfi-Donegan Deidre
Published: July 2023

Introduction Metformin is the most prescribed medication in Diabetes Mellitus(DM). Metformin has shown to decrease mean platelet volume, with promising antiplatelet effects. High doses of Metformin have also been associated with hypercoagulation. We hypothesize that Metformin will protect DM mice from occlusive arterial thrombus formation by altering platelet activation and mitochondrial bioenergetics. Methods DM was developed by low dose of Streptozotocin, healthy (non-DM) mice are controls. Either vehicle or Metformin was administered twice daily via oral gavage for 7-days. Ferric chloride (FeCl3) arterial thrombosis and tail bleeding time were performed. Whole blood aggregometry, platelet activation/adhesion and mitochondrial bioenergetics were evaluated. Results Metformin decreased susceptibility of DM mice to arterial thrombosis. Platelet bioenergetics show DM mice have increased platelet mitochondrial respiration, but no differences were observed with Metformin treatment. In healthy mice, Metformin modulated ADP-dependent increase in platelet adhesion. In healthy mice, Metformin shortens bleeding time with faster thrombotic occlusion. Metformin also increased platelet mitochondrial maximal respiration and spare respiratory capacity uniquely in healthy mice. Conclusion Metformin regulates platelet bioenergetics and ADP-mediated platelet function in DM mice which attenuates susceptibility to arterial thrombosis. Future studies will evaluate clinically relevant doses of Metformin that regulates thrombotic function in diabetic platelets.
LINC01224 promotes the Warburg effect in gastric cancer by activating the PI3K/AKT/mTOR/HIF-1α axis
Authors: Bin Yuling , Liu Minji , He Rong , Tang Pingfei , Qu Weiming , Wu Dajun , Tan Lin , Ai Qiongjia , Wang Qian , Jiang Peng , Li Defeng , Hu Hongsai
Published: July 2023

BACKGROUND: Gastric cancer (GC) is an aggressive malignancy, and patients with advanced-stage GC have high rates of morbidity. The long intergenic non-protein coding RNA 1224 (LINC01224) functions in the pathogenesis of many cancers. We performed in vitro and in vivo studies of the pathogenesis of GC to investigate the effects and mechanism of LINC01224 in this cancer.
METHODS: qRT-PCR was used to measure the expression of LINC01224, and qRT-PCR and western blotting were used to measure the expression of genes in the PI3K/AKT/mTOR/HIF-1α axis (phosphoinositide 3-kinase [PI3K], AKT, mammalian target of rapamycin [mTOR], and hypoxia-inducible factor 1 [HIF-1α]) in GC cells. The function of LINC01224 in GC cells was determined using transfection experiments and measurements of cell viability, cell proliferation, colony formation, apoptosis, cell migration, and cell invasion. Glucose metabolism was evaluated using a glucose uptake assay and measurements of lactate. A tumor xenograft model was used to examine the effect of LINC01224 on GC growth in vivo.
RESULTS:Up-regulation of LINC01224 in GC cells activated the PI3K/AKT/mTOR/HIF-1α axis and promoted aerobic glycolysis, thereby increasing cell viability, proliferation, migration, and invasion, and decreasing apoptosis. Down-regulation of LINC01224 had the opposite effects.
CONCLUSION: LINC01224 promotes the in vitro and in vivo pathogenesis of GC due to upregulation of aerobic glycolysis by activation of the PI3K/AKT/mTOR/HIF-1α axis. These results imply that future studies of GC should examine the effect of targeting of LINC01224 as a treatment strategy.
Die Entwicklung technikbezogener Überzeugungen im Rahmen inklusionspädagogischer Professionalisierung im Lehramtsstudium Sekundarstufe während der Corona-Semester
Authors: Rogge Franziska , Wagner Simon , Nowak Verena , Liebner Saskia , Entrich Steve R. , Krauskopf Karsten , Knigge Michel
Published: July 2023

Die pandemiebedingte ad hoc Digitalisierung von Lehrveranstaltungen im Frühjahr 2020 war für Lehrende wie Lernende Chance und Herausforderung zugleich. Befunde zeigen, dass das flexible selbstständige Arbeiten und Kennenlernen von Potenzialen des digitalen Lehrens und Lernens positiv wahrgenommen, aber als besonders herausfordernd erlebt wurden. Ferner sind digitale Kompetenzen angehender Lehrkräfte eher gering ausgeprägt. Inklusionspädagogisch betrachtet können digitale Kompetenzen aber beispielsweise bei der Gestaltung von Individualisierungsmaßnahmen hilfreich sein. Dieser Beitrag betrachtet vor dem Hintergrund inklusionspädagogischer Professionalisierung von Lehrkräften im Studium die Entwicklung digitaler Kompetenzen längsschnittlich über den Verlauf von 3 Semestern (SoSe 2020 bis SoSe 2021) während der Covid-19-Pandemie. Hierfür wurden Latent Change Score Modelle für die Entwicklung der Technikbereitschaft als Facette digitaler Kompetenzen spezifiziert. Die Ergebnisse zeigen, dass sich Technikkontrollüberzeugung und -akzeptanz als Facetten der Technikbereitschaft im Verlauf der untersuchten Semester jeweils positiv entwickelten. Die Lehramtsstudierenden betrachteten demnach eigene digitale Kompetenzen zunehmend als Teil ihrer eigenen Professionalisierung, was ein positiver Ausgangspunkt für die Gestaltung inklusiver Bildungssettings in der Kultur der Digitalität sein kann.
 
Abstract
The pandemic-related ad hoc digitisation of courses in spring 2020 was both an opportunity and a challenge for teachers and students. Findings show that flexible independent work and learning about the potential of digital teaching and learning were perceived positively, but experienced as particularly challenging. At the same time, digital competences of prospective teachers are rather low. In terms of inclusive education, however, digital competences can be helpful, for example, in the design of individualisation of teaching and learning. This article examines the development of digital competences longitudinally over the course of three semesters (summer semester 2020 to summer semester 2021) during the Covid 19 pandemic against the backdrop of the professionalization of teachers in inclusion pedagogy during their studies. For the investigation, latent change score models for the development of technology readiness as a facet of digital competences were specified. The results showed that technology control conviction and acceptance as facets of technology readiness developed positively in the course of the semesters investigated. Accordingly, the student teachers increasingly considered their own digital competences as part of their professionalization, which can be a positive starting point for the design of inclusive educational settings in the culture of digitality.
Controlled synthesis of MWCNTs/V2O5 nanocomposite by hydrothermal approach for adsorption and photodegradation processes
Authors: Ashery Marwa H. , Elsehly E. M. , Elnouby Mohamed , EL-Maghraby E. M.
Published: July 2023

The current paper outlines the synthesis of pristine multi-wall carbon nanotubes (PMWCNTs)/Vanadium pentoxide V2O5 and functionalized multi-wall carbon nanotubes (FMWCNTs)/V2O5 nanocomposite for photocatalytic applications. The FMWCNTs were obtained by the oxidizing agents (H2SO4 and HNO3) to introduce the oxygenated functional groups. The samples were synthesized by hydrothermal approach and investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy analysis (EDX), and Fourier transform infrared spectroscopy (FTIR). The photocatalytic activity of multi-wall carbon nanotubes (MWCNTs), FMWCNTs/V2O5, and PMWCNTs/V2O5 nanocomposites was assessed via methylene blue (MB) degradation from water under visible light. The results demonstrated that the removal efficiency of MB by PMWCNTs, FMWCNTs/V2O5, and PMWCNTs/V2O5 could reach 90.4, 98.9, and 94.9%, respectively. It was noticed that MB adsorption and photodegradation tend to follow pseudo-second-order kinetics. The mechanism of MB photodegradation by FMWCNTs/V2O5 nanoparticles was explained. MWCNTs/V2O5 nanocomposites will allow further applications to remove other dyes and contaminants from wastewater.
origen de la leyenda sobre un pacto con el diablo en Alto Lucero, Veracruz
Authors: Contreras Perez Rafael Miguel
Published: July 2023

Este artículo presenta el rescate y la interpretación de la leyenda de Julián, el Gavilán, originada a principios del siglo XX, en el México posrevolucionario, que relata las fantasías creadas por el imaginario social del pueblo de Alto Lucero, Veracruz (México). Dicha leyenda explica la vida y muerte de Julián, a quien la comunidad acusó de pactar con el diablo. Él vestía de negro y frecuentaba el panteón por las noches. En esa época resultaba extraño que existieran personas dedicadas a borrar a aquellos que estorbaran para los fines personales. Cuenta la leyenda que Julián tuvo un pacto con el diablo para que lo protegiera en su camino y en su trabajo de sicario. Es así que el objetivo de este trabajo es interpretar el origen de dicha leyenda desde la perspectiva psicodinámica.
Calidad de vida en barrios urbanos en Jeddah, Arabia Saudita
Authors: Majrashi Abdulaziz Abdurahman
Published: July 2023

La calidad de vida se ha convertido en un concepto cada vez más importante en los últimos tiempos. Últimamente, la noción ha recibido gran atención por parte de gobiernos, organizaciones y tomadores de decisiones en todo el mundo. El Reino de Arabia Saudita es uno de los países que en los últimos años se ha enfocado en mejorar la calidad de vida de sus ciudadanos y visitantes a través del marco Vision 2030, bajo el Programa Quality of Life. Este estudio tiene como objetivo evaluar la situación actual en el barrio de Al-Aziziyah en la ciudad de Jeddah. Se empleó un enfoque exploratorio para llevar a cabo la investigación. Se utilizaron conjuntos de indicadores para evaluar la vivienda y la circulación en el área de estudio. Los hallazgos del estudio revelaron que la calidad de vida ha mejorado con el suministro de viviendas de calidad, instalaciones de atención médica, espacios verdes/abiertos y otras instalaciones/servicios urbanos relacionados. Los hallazgos también están en línea con los requisitos del Objetivo de Desarrollo Sostenible (ODS) 11 para asentamientos humanos/ciudades sostenibles. El estudio recomienda además estudios comparativos entre ciudades del Reino y ciudades de naciones con la mejor calidad de vida.
Bioactive compounds, antioxidant and antibacterial properties of the pulp, peel and aril of the fruit of Clusia quadrangula (Clusiaceae)
Authors: Martínez-Mendoza Beatriz Itzel , Juárez-Trujillo Naida , Mendoza-López María Remedios , Monribot-Villanueva Juan Luis , Guerrero-Analco José Antonio , Jiménez Fernández Maribel
Published: July 2023

Background and Aims: The Clusiaceae family is known for its bioactive compounds with beneficial antioxidant and anti-inflammatory properties. The objectives of this study were to 1) identify and quantify the individual polyphenol compounds in the methanolic extract from peel, pulp and aril of the fruit of Clusia quadrangula by UPLC-MSMS, evaluate their antioxidant properties, 2) analyze the fatty acid profile, minerals composition and 3) determine the antibacterial activity against pathogenic bacteria of the methanolic extract.Methods: Physicochemical properties, antioxidants and bioactive compounds, fatty acid profile and mineral content were analyzed using a Microplate Spectrophotometer, Ultra High Performance Liquid Chromatography coupled with a triple quadrupole Mass Spectrometer, Gas Chromatography coupled with a Mass Spectrometer and Microwave Plasma Atomic Emission Spectroscopy.Key results: Twenty phenolic compounds were identified and quantified plus the precursor shikimic acid (103.55 µg/g solids). Procyanidin B2 (41.56 µg/g solids), (−)-epicatechin (34.07 µg/g solids), and ellagic acid (27.58 µg/g solids) were found in greater quantity in the methanolic extract of the pulp. Palmitic and linoleic acid were the most abundant fatty acids in the pulp, peel, and aril, and linolenic acid was present in the pulp. The pulp also exhibited the highest amount of total polyphenolic compounds (24.33 mg GAE/g) and reducing power evaluated by FRAP (18.697 mg ET/g). Analysis of the minerals revealed that all fractions are rich in magnesium, potassium, sodium, and calcium. The results showed that the methanolic extract of the different parts of the fruit had antibacterial properties against Salmonella typhi, Escherichia coli, Staphylococcus aureus, and Enterococcus faecalis. Conclusions: These results indicate that different parts of the C. quadrangula fruit are a rich source of natural antioxidants and possess antibacterial properties. Therefore, it can be considered for use as ingredient or additive in the cosmetic, pharmaceutical, or food industries.
Gastronomy as Content in Social Media Facebook: Potentials and challenges
Authors: Ishak Maizatul Akhmal , Abdull Rahman Zainatul Shuhaida
Published: July 2023

Gastronomy represents food as content through social media, explaining the potential of creating content for creative industries in Malaysia. However, gastronomy as a creative culture has the challenge of sustaining in this digital era. Therefore, this paper attempt to see potential and challenge gastronomy as content besides look feedback based on social media Facebook, by explaining gastronomy as part of creative industries. Qualitative content analysis and thematic analysis were used in this paper, involving one posting on Facebook containing the comment. Results revealed potential and challenge gastronomy content that contributes to the ideas to create content for both creative and food industries.
Aesthetic Objectivism : Instapoetry ‘Dark Love’ through Lang Leav’s Poetry (2013-2016)
Authors: Ismail Norlela , Shamsul Bahrain Aishah Humaira'
Published: July 2023

The themes of Lang Leav's poems are mostly about love, loss and loneliness. Her poetry is very well received by many and is also said to promote a toxic view of love. This paper aims to examine the themes of love which we argue contain the elements of dark love. Dark love is divided into 'love as a sad notion' and 'love as a hopeless infatuation'. A textual analysis is done on selected poems using Frank Sibley's aesthetic theory of objectivism (1959). The analysis reveals that the poems promote 'dark love' that is grim, disappointing and pessimistic.
Documenting the Complete Recordings of Biduan Negara Puan Sri Saloma 1970 to 1983
Authors: Basyah Sallehuddin Ahmad Kamal , Ali Abdul Walid
Published: July 2023

Biduan Negara Puan Sri Datin Amar Saloma, or her real name Salmah Ismail, was born on January 22, 1935, in Pasir Panjang, Singapore. She started singing professionally at 13. For a legendary singer of her stature, unfortunately, Saloma's contribution to the music industry in this country has not been properly documented, appreciated, and upheld. It is not known how many albums Saloma had released in the first 10 years of her career, as EMI Malaysia Sdn Bhd, the local distributor of artists signed to EMI Singapore Pte Ltd. As a result, most albums before 1970 were not listed.
Lubang Indah: The pothole installation art
Authors: Romat Muhammad Sukor , Shamsudin Muhammad Khairi , Amir Hamzah Ahmad Fauzi , Jamaludin Noor Azzanny
Published: July 2023

The effects of the epidemic of COVID-19 can be seen in the natural deterioration of the roads. Self-isolation and curfews during the pandemic further exacerbate the mental health problem. Through this project, the researchers hoped to convey the negative impression of the pothole-strewn streets through an art installation. Using an artistic medium is one way to counteract the negative perception people have of potholes. In this project, freshly picked flowers, with only stems and no branches, were placed in the pothole. In this way, actual activity can be recorded based on the design of potholes.