bluuebunny/crossref_metadata_2025 huggingface dataset:
Numerical Approach of Fishing Vessel Hull Form to Measure Resistance Profile and Wave Pattern of Mono-Hull Design
Authors: Aldias Bahatmaka  , Muhammad Yusuf Wibowo  , Andi Abdullah Ghyfery  , Muhammad Harits  , Samsudin Anis  , Deni Fajar Fitriyana  , Rizqi Fitri Naryanto  , Andri Setiyawan  , Rizki Setiadi  , Aditya Rio Prabowo  , Kim Dong Joon
Published: May 2023

Indonesia is a maritime country with two-thirds of its territory is the ocean. Indonesia has a diversity of marine resources with a total fish production continuing each year to reach 8.02 million tons. The traditional fishing vessel is one of transportation and livelihood support in Indonesia and the vessel was made based on the knowledge from generation to generation. Thus, the investigation of the fishing vessels must be conducted to measure the resistance profile and wave pattern. This analysis is conducted to consider the mono-hull fishing vessel design. The use of a numerical approach is rapid to predict the performance of ship design. The resistance analysis is investigated using Savitsky’s mathematical model and Holtrop’s regression method. Comparing studies is the main focus to describe the effectiveness of the methodology. The research will present the three variations of the hull for the mono-hull design. By comparing both methods, the best design makes the methods well enough to be used for resistance analysis, especially in the fishing vessel design.
Study on Impact of Magnetic Dipole and Thermal Radiation on Flow/Heat Transfer of Jeffery Fluid over Stretching Sheet with Suction/Injection
Authors: Michael Iyoko  , Bakai Ishola Olajuwon
Published: May 2023

In many industries, the knowledge of boundary layer flow and transfer of heat over a stretching sheet is applied. Getting the desired product from these industrial processes is usually a problem. Hence, the purpose of this examination was to establish the impact of thermal radiation and magnetic dipole on the movement and conveyance of heat in Jeffery fluid over a stretching surface that is linear. The model equations of the problem are converted into coupled nonlinear ordinary differential equations employing similarity transformations. The Chebyshev spectral collocation method was utilized to get a solution for the fluid’s velocity and temperature. The different parameters in the problem are varied to determine their influence; these effects are represented by tables and graphs as determined by the prescribed surface temperature (PST) and prescribed heat flux (PHF) thermal processes. Results for particular cases are compared with those gotten by the Generic algorithm and Nelder Mead method, and a very good agreement exists. Thermal radiation causes an increment in temperature for PST and PHF processes, while magnetic dipole reduces the velocity of the fluid and increases temperature for the case of PST whereas it exhibits both an increase and decrease in temperature for the PHF case.
Carcinosarcoma uterino presentándose como masa cervical – reporte de un caso
Authors: Earle Hernández Guillermo
Published: April 2023

El carcinosarcoma es un tumor poco frecuente que se presenta principalmente en el tracto genital femenino. Su característica más importante es la presencia sincrónica de un componente epitelial maligno (carcinoma) y un componente mesenquimal maligno (sarcoma). Estudios recientes demuestran que la mayoría de las veces el componente sarcomatoso se origina de una diferenciación metaplásica del componente epitelial. Debido a su poca frecuencia, no se conoce con certeza la relación entre las distintas presentaciones histológicas con los posibles factores de riesgo asociados, el pronóstico y la respuesta terapéutica. En este trabajo se reportaron las características histopatológicas y la expresión inmunohistoquímica de un caso de carcinosarcoma uterino en una paciente de 73 años que se presentó inicialmente como una masa cervical. El patrón microscópico documentado fue el de un tumor epitelial de bajo grado asociado a un componente mesenquimal con diferenciación rabdomiosarcomatosa (inmunohistoquímica positiva para desmina y miogenina). La documentación fenotípica es importante para en un futuro desarrollar posibles opciones terapéuticas dirigidas a los distintos patrones histológicos y determinar su posible asociación con factores de riesgo.
Reclasificación de variante de significancia clínica incierta en un caso de MPS tipo IV-A no clásica
Authors: Goméz De la Rosa Richar José , Moreno giraldo Lina johanna
Published: April 2023

Introducción: La mucopolisacaridosis tipo IV - A (MPS IV-A, Síndrome de Morquio tipo A) es un trastorno hereditario autosómico recesivo y una de las enfermedades lisosómicas comunes, causada por el déficit en la actividad de la hidrolasa lisosómica, N-acetilglucosamina-6-sulfatasa (GALNS) lo cual conlleva a una acumulación de glucosaminoglucanos (GAG) como queratán sulfato (KS) y condroitin-6-sulfato (C6S) en múltiples tejidos. Como en las otras MPS, existen distintos fenotipos, que varían desde formas graves también denominada MPS IV-A clásica hasta formas leves llamada MPS IV-A atenuada o no clásica. Material y métodos: Reporte de caso clínico. Los análisis realizados en aislamientos leucocitarios se realizaron por sedimentación usando Dextran-Heparina, liberando la enzima por sonicación y ajustando la concentración proteica, la valoración enzimática se realizó mediante un ensayo fluorométrico, el análisis de secuencia de los genes de interés se realizó mediante secuenciación de nueva generación (NGS) y el análisis in silico se realizó con herramientas de bioinformáticas para predicción del efecto biológico de la variante. Resultados: Paciente masculino de 12 años con diagnóstico clínico, paraclínico, enzimático y estudio molecular con dos variantes heterocigóticas, una con clasificación de significancia clínica patogénica y la otra con significancia clínica incierta de MPS IV-A, con posterior reclasificación de significancia de acuerdo con las recomendaciones del Colegio Americano de Genética Médica Y Genómica Y La Asociación de Patología Molecular, y su correlación fenotipo, endotipo y genotipo. Conclusiones: La MPS IV-A de manera atenuada representa un reto diagnóstico para profesionales de la salud por lo que es de gran importancia identificar de modo precoz manifestaciones clínicas leves de la enfermedad. A través del uso de herramientas de bioinformática se logró establecer la significancia patogénica de la variante sin sentido c.1088T>C (p. Ile363Thr) y de esta forma se reportarla como variante nueva asociada a MPS IV-A.
Entre persecuciones y crímenes, los códigos de ética
Authors: Vargas Pedro
Published: April 2023

Jurar y aceptar códigos de conducta, que no son otra cosa que códigos de ética, constituyen la entrada a la profesionalidad médica como a la dedicación a la investigación. “Los profesionales de la Medicina tienen deberes, obligaciones, privilegios y un status protegido, pero también se rigen por los más altos estándares éticos”, nos dice Phalen. El Colegio Médico de Panamá lo recuerda en su Código de Ética, cuando trae la frase de Rabelais, médico y filósofo del siglo XVI: “la ciencia sin conciencia es la ruina del alma”, para resaltar lo “indispensable de una permanente reflexión ética que fortalezca la conciencia y nos recuerde el núcleo de vocación y servicio al prójimo”.
 
Los humanos más tempranos ya practicaron especializaciones profesionales relacionadas con la salud, como lo revelan hallazgos arqueológicos y estudios antropológicos. Los primeros médicos en la historia, ambos nacidos en Egipto, Imhotep, varón y Merit Ptah, mujer, declararon juramentos a sus dioses, nos sigue relatando Robert F. Phalen, basados en varios atributos éticos: no mentir, no matar, no engañar.
Batı Marmara Bölgesindeki Bir Üniversite Hastanesinde İnfertilite Tedavisi Gören Kadınların Damgalanma, Stres ve Depresyon Düzeylerinin Belirlenmesi
Authors: AKSU Sevde , ŞAYAN Özge
Published: May 2023

Amaç: Bu çalışma, Batı Marmara bölgesindeki bir üniversite hastanesinde infertilite tedavisi gören kadınlardaki damgalanma, stres ve depresyon düzeylerinin belirlenmesi amacıyla yapılmıştır. Yöntem: Kesitsel ve tanımlayıcı tipte olan araştırmanın örneklemini Batı Marmara bölgesindeki bir üniversite hastanesinin Doğum ve Kadın Hastalıkları polikliniğine 1 Kasım 2021-31 Aralık 2021 tarihleri arasında infertilite tedavisi için başvuran 181 kadın oluşturmuştur. Veriler; Tanıtıcı Bilgi Formu, İnfertilite Damgalanma (Stigma) Ölçeği, İnfertilite Stres Ölçeği ve Beck Depresyon Ölçeği kullanılarak toplanmıştır. Elde edilen veriler SPSS 25 paket programı kullanılarak analiz edilmiştir. Bulgular: Çalışmaya katılan kadınların yaş ortalaması 30,88±5,91 yıl olup %39,2’inin lise mezunu, %61,9’unda primer infertilite, %46,4’ünün infertilite nedeninin kadına ait olduğu, %79’unun tedavi süreci hakkında bilgi aldığı ve %48,1’inin süreç hakkında iyi düşüncede olduğu belirlenmiştir. İnfertilite tedavisi gören kadınların; İnfertilite Damgalanma Ölçeği toplam puan ortalamasının 67,93±22,62; İnfertilite Stres Ölçeği toplam puan ortalamasının 23,30±11,07; Beck Depresyon Ölçeği toplam puan ortalamasının 39,16±11,55 olarak belirlenmiştir. İnfertilite Damgalanma Ölçeği ve İnfertilite Stres Ölçeği alt boyut ve toplam ölçek puanları ile Beck Depresyon Ölçeği toplam puanları arasında pozitif yönde, istatistiksel olarak anlamlı korelasyon bulunmuştur (p<0,05). Buna göre damgalanma arttıkça, infertiliteye bağlı depresyon ve stres arttığı tespit edilmiştir. Sonuç: Çalışma sonucunda infertilite tedavisi gören kadınlarda damgalanma arttıkça, infertiliteye bağlı depresyon ve stres düzeylerinin de arttığı belirlenmiştir.
Yeme Arzusu Kabullenme ve Davranış Ölçeği’nin Türkçe Uyarlamasının Geçerlilik ve Güvenilirlik Çalışması
Authors: HAMURCU Pınar , ŞAHİN İrem Nur , ÇELİK Abdullah
Published: May 2023

Amaç: Bu çalışmada “Food Craving Acceptance and Action Questionnaire (FAAQ)”ın Türkçe uyarlaması “Yeme Arzusu Kabullenme ve Davranış Ölçeği (YAKDÖ)”nin geçerlilik ve güvenilirliğini ortaya koymak amaçlanmıştır.
Yöntem: Metodolojik araştırma tasarımı kullanılan çalışma, 2021-2022 akademik yılında Üsküdar Üniversitesi’nde 385 katılımcıyla yürütülmüştür. Google Formlar’da yapılandırılmış bir anket aracılığıyla Bilgi Formu, Yeme Arzusu Kabullenme ve Davranış Ölçeği (YAKDÖ) ve Yeme Arzusu Ölçeği Kısa Formu (FCQT-R) uygulanmıştır. İstatistiksel değerlendirmede iç tutarlılık katsayısı, faktör analizleri ve korelasyonları IBM SPSS26® yazılımı ile yapılmıştır.
Bulgular: YAKDÖ’nün 79 kişi ile yürütülen pilot çalışmasında, Cronbach’s Alpha değeri 0,807 bulunarak, ölçeğin yüksek güvenilirlikte olduğu ve ölçekten madde çıkartılmadan, geçerlilik analizine uygun olduğu belirlenmiştir. Asıl çalışmanın 150 örneklemiyle gerçekleştirilen Açımlayıcı Faktör Analizi’nde, Kaiser-Mayer-Olkin değeri 0,903 ile örneklem hacminin çok iyi düzeyde yeterli olduğu ve Bartlett Küresellik Testi ile χ2=972,116 ve p=0,000 düzeyinde istatistiki açıdan anlamlılık olduğu bulunmuştur. Faktör yükleri >0,20 ve öz değerleri >1 olan ve toplam varyansın %69,078’ini açıklayan iki faktörlü bir yapı saptanmıştır. Asıl çalışmanın diğer 235 örneklemiyle gerçekleştirilen Doğrulayıcı Faktör Analizi’nde 10 maddelik versiyonun uyum iyiliği indeksleri RMSEA=0,048; CFI=0,969; GFI=0,978; NFI=0,951; SRMR=0,088; AGFI=0,964; χ2/df=1,904 olarak yeterli uyum gösterdiği saptanmıştır. İç tutarlılık analizinde Cronbach’s Alpha katsayısı 0,924 olarak bulunmuştur.
Sonuç: Bireylerin yeme isteklerini ve besin kabullerini değerlendirmeyi amaçlayan Yeme Arzusu Kabullenme ve Davranış Ölçeği (YAKDÖ)’nin Türkçe uyarlaması geçerli ve güvenilir bir ölçüm aracıdır.
PENGEMBANGAN MEDIA PEMBELAJARAN MATEMATIKA BERBANTUAN GEOGEBRA UNTUK MENINGKATKAN KEMAMPUAN PEMAHAMAN KONSEP MATEMATIS SISWA
Authors: Rangkuti Rizki Kurniawan , Suprihatiningsih Siti , Rahayu Sri , Razy Miftah Ar
Published: April 2023

Penelitian ini membahas tentang pengembangan media pembelajaran matematika berbantuan GeoGebra untuk meningkatkan kemampuan pemahaman konsep matematis siswa. (1) Untuk mengetahui bagaimana proses pengembangan media pembelajaran matematika berbantuan GeoGebra untuk meningkatkan kemampuan pemahaman konsep matematis siswa, (2) Untuk mengetahui bagaimana tingkat (kevalidan, kepraktisan, dan keefektifan) media pembelajaran matematika berbantuan GeoGebra untuk meningkatkan kemampuan pemahaman konsep matematis siswa. Jenis penelitian yang digunakan adalah Research and  Development (Penelitian dan Pengembangan) dengan mengacu pada model  pengembangan ADDIE, yaitu Analysis (Analisis), Design (Perancangan), Development (Pengembangan), Implementation (Penerapan), dan Evaluation (Evaluasi). Berdasarkan hasil uji coba media pembelajaran matematika berbantuan GeoGebra, diperoleh lembar kerja siswa berbantuan GeoGebra, angket respon siswa, rencana pelaksanaan pembelajaran dan tes pemahaman konsep pada interval 2,5 ≤ 𝑀 < 3,5 dengan kategori valid. Media pembelajaran matematika yang telah valid kemudian di terapkan dalam proses pembelajaran untuk melihat kepraktisan dan keefektifan media pembelajaran. Media pembelajaran yang dikembangkan dinyatakan praktis dengan melihat hasil analisis angket respon siswa berada pada persentase 80%. Keefektifan media pembelajaran dilihat dari hasil analisis tes hasil belajar yang menunjukkan bahwa persentase ketuntasan belajar siswa  sebesar 80% dan persentase ketidaktuntasan sebesar 20% selain itu, persentase aktivitas siswa sebesar 62,14%. Maka media pembelajaran berbantuan GeoGebra yang dikembangkan valid, praktis, dan efektif.
KEMAMPUAN PEMECAHAN MASALAH PADA PEMBELAJARAN PROGRAM LINIER DENGAN MODEL ARTIKULASI
Authors: Nifrani Nila , Sutiarso Sugeng
Published: April 2023

Tujuan penelitian ini adalah untuk mengetahui: (1) perbedaan rata-rata kemampuan pemecahan masalah siswa yang diperoleh melalui model pembelajaran Artikulasi dengan menggunakan model pembelajaran langsung. Populasi adalah 33 siswa yang diambil dari 2 kelas, kelas XI B sebagai kelas eksperimen dan kelas XIA sebagai kelas kontrol. Hasil penelitian menunjukkan bahwa ada perbedaan rata-rata kemampuan pemecahan masalah matematika siswa antara kelas eksperimen dan kelas kontrol dan rata-rata kemampuan pemecahan masalah siswa di kelas eksperimen lebih tinggi daripada rata-rata kemampuan pemecahan masalah matematika siswa di kelas kontrol.
Influence of Employee Soft Skills on Job Performance
Authors: Shillie Peter Ngek , Nchang Nicoline Neba
Published: May 2023

Purpose: Due to COVID-19's global impact, work from remote has become the norm which led to the closure of offices throughout the globe. Workplace learning, communication skills, collaboration, and emotional intelligence are all examples of soft skills, and they are crucial in the workplace. They are likely to boost workers' efficiency and effectiveness on the job. This study is sought to examine the relationships between employee soft skills and job performance based on evidence from Small and Medium Size Enterprises in the Bamenda Metropolis of Cameroon.
Methods: A mixed-method (quantitative and qualitative) research design was used in this paper. Data were collected from 241 SMEs using a structured questionnaire. Data analysis used both descriptive and inferential statistics.
Results: Results show that improving communication skills results in higher job performance. Further, it is found that the higher the capacity of employees to discern and manage their emotions the better the job performance. Teamwork is revealed to increase the level of job performance. Work ethics shows a minimal effect on work performance.
Implications: SME management should focus on developing employees’ emotional intelligence as this will improve their job performance. SMEs that are yet to adopt effective teams as an approach to functioning should consider doing so following the established benefits of effective teamwork in the organization. Employers also should try to cultivate a culture of work ethic at their place of work.
Two new Palaearctic species of Xynobius Foerster (Hymenoptera, Braconidae, Opiinae)
Authors: Han Yunjong , van Achterberg Cornelis , Lee Heung-Sik , Kim Hyojoong
Published: May 2023

Two new and very similar species of the genus Xynobius Foerster, 1863 are described and illustrated, X. subparallelus Han & van Achterberg, sp. nov. from Japan (Honshu) and X. setosiscutum van Achterberg, sp. nov. from Norway. Three species are newly reported from Norway: Xynobius aciculatus (Thomson, 1895), X. comatus (Wesmael, 1835), and X. polyzonius (Wesmael, 1835). X. polyzonius (Wesmael, 1835) and X. sapporanus (Fischer, 1963) are new combinations. Identification keys to the Xynobius species known from Norway and Japan are added.
Further notes on the taxonomy of the land snail family Clausiliidae Gray, 1855 (Stylommatophora, Helicina) from Myanmar with description of two new species
Authors: Man Nem Sian , Lwin Ngwe , Sutcharit Chirasak , Panha Somsak
Published: May 2023

This study presents a complete species list of the door snails inhabiting Myanmar, updated to now include 33 taxa, and provides taxonomic notes together with a re-description of the shell, radula, and genitalia for 13 species and subspecies, includingOospira philippiana, the type species of the genusOospira. The snails previously treated as subspecies or synonyms ofOospira graciliorandOospira magnaare reclassified and recognized as distinct species. The lectotype ofOospira insignishas been clarified and an illustration of the original type specimen provided. A long-overlooked species,Oospira andersoniana, has been collected and redescribed herein. Two new species from the limestone karsts in the Salween River Basin are introduced:Oospira luneainopsisMan & Panha,sp. nov.andOospira zediopsisMan & Panha,sp. nov.A synoptic view of all clausiliid taxa known from Myanmar is presented along with taxonomic information and distributional records. Photographs of the type materials for all taxa are provided for further comparison or, if unavailable, photographs of the examined specimens or the original figure from the literature.
La laïcité comme spiritualité
Authors: Castillo Monique
Published: May 2023

Le fantasme totalitaire de l’activisme djihadiste se confond avec une demande accrue de religion. La république peut-elle refonder son pouvoir symbolique, c’est-à-dire son autorité, en se référant à une laïcité conçue comme une spiritualité culturelle ?
L’impensé de la République
Authors: Lazorthes Frédéric
Published: May 2023

Les terribles attentats qui ont marqué l’année 2015 en France ont rendu plus nécessaire que jamais le sentiment d’appartenir à un gouvernement commun par-delà les divisions. Le recours aux valeurs républicaines sera-t-il une réponse suffisante face à la décomposition civique ? Ne vaudrait-il pas mieux retrouver le sens d’une république libérale qui invite les citoyens à prendre part à un gouvernement libre plutôt que de réclamer toujours plus d’autorité ?
L’aviation française en 1940. 1. Le « mystère » du nombre des avions
Authors: Nassiet Michel
Published: May 2023

Sur le nombre des avions français en 1940, d’apparentes incertitudes ont fait alléguer que beaucoup n’auraient pas été engagés dans la bataille, ce qui a été interprété comme une impéritie. On précise ici comment ce prétendu « mystère » résulte de biais dans des comptages grossiers. Le réarmement aérien n’ayant été décidé qu’en mars 1938, l’étude de deux statistiques, au 1 er  février et au 10 mai 1940, permet de mesurer les avancées inégales du processus de rénovation de la flotte aérienne. Dans le cas de la chasse, une seconde rénovation dut être menée au cours même de la bataille, ce qui fut chaotique. La finalisation des appareils se heurtait à de multiples et inévitables difficultés techniques et industrielles. Pire encore, cependant, était un autre handicap, l’insuffisance des ressources humaines : le manque de mécaniciens et de pilotes.
Knee pain – thinking beyond degeneration: a systematic review
Authors: Kaur J. , Gera C. , Malik M. , Pawalia A.
Published: May 2023

Knee pain is the most common and challenging pain, that affects the performance and activities of daily living. Apart from the bones, the surrounding neuromuscular structures too are an integral part of the knee joint. The development of knee pain due to these surrounding neuromuscular structures, i.e. hip joint and ankle-foot complex is studied in this literature review. This systematic review was done for the purpose to summarise the literature mainly related to various neuromuscular factors related to neuro-muscle imbalances that affect knee pain other than degeneration. Observational studies related to knee pain published up to 2020 were reviewed in this paper. Strength of hip muscles and foot alignment were included in the study. We searched electronic database online for articles on ‘muscular imbalance that causes knee pain’ from Google scholar & PubMed the quality of the selected researches was measured by using PEDro scale. Of the total, 14 selected studies demonstrated that individuals with knee pain had decreased muscular strength for hip abduction, external rotation and extension on the affected side compared with healthy individuals. Flat foot, abnormal Q angle and over pronation or supination of foot can also results in knee pain. This review concluded that hip muscle weakness and abnormal subtalar mal-alignment place extra stress on knee and create muscular imbalance leading to knee pain. This should be prevented by either proper posture or strengthening programs.
Adolescents' Perceptions of Functional Seizure Self-Management Strategies, Facilitators, and Barriers in the School Environment
Authors: Tanner Andrea L. , von Gaudecker Jane R. , Buelow Janice M. , Oruche Ukamaka M. , Miller Wendy R.
Published: May 2023

Adolescents with functional (psychogenic nonepileptic) seizures encounter many struggles within the school environment, including stress, bullying, stigmatization, and accusations of faking seizure events. Mental health nurses and school personnel are poised to support school-based self-management; unfortunately, to date, no evidence exists to detail effective school-based self-management strategies for adolescents with functional seizures. Therefore, in the current qualitative study, we examined adolescents' functional seizure self-management, perceived effectiveness, and facilitators and barriers using semi-structured interviews analyzed using content analysis. We interviewed 10 adolescent females aged 12 to 19 years. Themes of proactive (prior to seizure warning symptoms) and reactive (after seizure warning symptoms) self-management, involving protection, perseverance, and progress monitoring, emerged. Adolescents perceived proactive strategies as primarily effective, whereas reactive strategies were less effective. Adolescents identified school nurses and personnel, family, and peers as facilitators and barriers to self-management. Mental health nurses are positioned to provide care, co-create plans, and advocate for adolescents with functional seizures in collaboration with school nurses and personnel. [
Journal of Psychosocial Nursing and Mental Health Services, 61
(10), 19–27.]
Anthropological Ecology and Ecological Anthropology as a Framework for the Analysis of Socio-Ecological Sustainable Development
Authors: Vargas-Hernandez José G. , Higuera-Cota María Fernanda , Vargas-González Omar C.
Published: May 2023

This study is aimed to analyze the anthropological ecology and the ecological anthropology as a framework approach for the analysis of socio-ecological sustainable development. It departs from the assumption that sustainable development requires a socio-ecological approach sustained by anthropology and ecology. The method used is the analytical reflection based on the conceptual, theoretical, and empirical literature review. The study concludes that anthropology and ecology combine elements to sustain the anthropological ecology and ecological anthropology approaches to develop the framework for the analysis of a socio-ecological sustainable development.
Designing a Futuristic Solar Smart Bench for Smart Cities
Authors: Chakwesha Rodney Takudzwa , Musti K. S. Sastry
Published: May 2023

Several smart cities have been established all over the world and versatile infrastructure is being developed to enhance the resident experience. Environmentally friendly urban infrastructure development is critical for societal health and overall development. Solar smart benches are now gaining popularity in smart cities and indeed considered as part of essential infrastructure for futuristic smart cities. They produce electricity during the daytime and provide various services to users. This chapter presents engineering design and analysis of solar smart benches. Contemporary smart features have been considered and design alternatives have been developed. Technical specifications for the designs have been provided. Suitable information and communication technologies have been identified for putting the infrastructure to use. Solar smart benches have the potential to revolutionize the smart city ecosystem.
Organizational Socio-Ecology and Green Technological Innovation
Authors: Vargas-Hernandez José G. , Higuera-Cota María Fernanda , Vargas-González Omar C.
Published: May 2023

This study intends to analyze the impact of environmental regulation and incentives in socio-ecological and green technological innovation. It departs from the assumption that environmental regulation affects the performance of socio-ecological and green technological innovation in organizations. The method employed is critical analytical and reflective based on the theoretical, conceptual, and methodological literature. It is concluded that the analysis confirms that there is a direct relationship between the incentives of environmental regulation and the socio-ecological and green technological innovation in organizations.
Single Cell Analysis of High-Parameter Histology Images Using Histoflow Cytometry
Authors: Jain Rajiv W , Elliott David A , Yong V Wee
Published: May 2023

Immunofluorescence histology is commonly used to study immune cells in tissues where the number of fluorescence parameters is normally limited to four or less. This makes it impossible to interrogate multiple subsets of immune cells in tissue with the same precision as flow cytometry. The latter, however, dissociates tissues and loses spatial information. To bridge the gap between these technologies, we developed a workflow to expand the number of fluorescence parameters that can be imaged on widely available microscopes. We instituted a method for identifying single cells in tissue and exporting the data for flow cytometry–based analysis. This histoflow cytometry technique successfully separates spectrally overlapping dyes and identifies similar numbers of cells in tissue sections as manual cell counts. Populations identified through flow cytometry–like gating strategies are mapped to the original tissue to spatially localize gated subsets. We applied histoflow cytometry to immune cells in the spinal cords of mice with experimental autoimmune encephalomyelitis. We ascertained that B cells, T cells, neutrophils, and phagocytes differed in their frequencies in CNS immune cell infiltrates and were increased relative to healthy controls. Spatial analysis determined that B cells and T cells/phagocytes preferentially localized to CNS barriers and parenchyma, respectively. By spatially mapping these immune cells, we inferred their preferred interacting partners within immune cell clusters. Overall, we demonstrate the ease and utility of histoflow cytometry, which expands the number of fluorescent channels used in conventional immunofluorescence and enables quantitative cytometry and spatial localization of histological analyses.
Extracellular RNA Sensing Mediates Inflammation and Organ Injury in a Murine Model of Polytrauma
Authors: Suen Andrew O , Chen Fengqian , Wang Sheng , Li Ziyi , Zhu Jing , Yang Yang , Conn Olivia , Lopez Kerri , Cui Ping , Wechsler Laurence , Cross Alan , Fiskum Gary , Kozar Rosemary , Hu Peter , Miller Catriona , Zou Lin , Williams Brittney , Chao Wei
Published: May 2023

Severe traumatic injury leads to marked systemic inflammation and multiorgan injury. Endogenous drivers such as extracellular nucleic acid may play a role in mediating innate immune response and the downstream pathogenesis. Here, we explored the role of plasma extracellular RNA (exRNA) and its sensing mechanism in inflammation and organ injury in a murine model of polytrauma. We found that severe polytrauma—bone fracture, muscle crush injury, and bowel ischemia—induced a marked increase in plasma exRNA, systemic inflammation, and multiorgan injury in mice. Plasma RNA profiling with RNA sequencing in mice and humans revealed a dominant presence of miRNAs and marked differential expression of numerous miRNAs after severe trauma. Plasma exRNA isolated from trauma mice induced a dose-dependent cytokine production in macrophages, which was almost abolished in TLR7-deficient cells but unchanged in TLR3-deficient cells. Moreover, RNase or specific miRNA inhibitors against the selected proinflammatory miRNAs (i.e., miR-7a-5p, miR-142, let-7j, miR-802, and miR-146a-5p) abolished or attenuated trauma plasma exRNA-induced cytokine production, respectively. Bioinformatic analyses of a group of miRNAs based on cytokine readouts revealed that high uridine abundance (>40%) is a reliable predictor in miRNA mimic-induced cytokine and complement production. Finally, compared with the wild-type, TLR7-knockout mice had attenuated plasma cytokine storm and reduced lung and hepatic injury after polytrauma. These data suggest that endogenous plasma exRNA of severely injured mice and ex-miRNAs with high uridine abundance prove to be highly proinflammatory. TLR7 sensing of plasma exRNA and ex-miRNAs activates innate immune responses and plays a role in inflammation and organ injury after trauma.
Improving the timeliness and completeness of childhood vaccination through color-coded bracelets: a pilot study among Fulani tribe populations in Nigeria
Authors: Yau Inuwa B. , Zubair Mustapha Mahmud , Nwaze Eric , Nobila Ouédraogo , Maigoro Aliyu , Abdullah Adamu , Gamawa Adamu , Meissner Peter , Albrecht Jahn , Müller Olaf
Published: May 2023

Background: Childhood immunization remains one of the most cost-effective public health interventions. Globally, millions of children are not being reached with safe and effective vaccines and Nigeria has the highest number of unprotected children. Objective: The effects of locally adapted interventions on vaccination timeliness and completeness were studied amongst Fulani populations across 6 health facilities in 2 districts of Bauchi State, Nigeria.Methods: The intervention group consisted of newborns who received 5-color-coded bracelets representing different immunization contacts, while the control group had no bracelets. Vaccination rates across contacts were followed for 11 months. In addition, mothers of children in the intervention group were voluntarily recruited as peer-to-peer mobilizers (PPM).Results: In this study, 435 children were studied. Vaccination completeness was higher in the intervention group compared to the control group at all contacts during follow-up. The difference was most noticeable at the fifth contact, with 158/256 (62%) children in the intervention group completing, compared to 73/179 (41%) in the control group (P0.0001). Vaccination timeliness was better in the intervention group compared to the control one, which reached statistical significance at the second and third vaccination contacts (P0.05). 68% of women volunteered as PPM and recruited 82 additional children for vaccination. Conclusion: This study demonstrated the feasibility of a composite intervention (bracelets and PPM) to increase the completeness and timeliness of childhood immunization and provided preliminary evidence for its efficacy among Fulani populations in Nigeria. Findings from this pilot study should be confirmed through a larger cluster randomized controlled trial.
Sedentariness and overweight in relation to mortality in sub-Saharan Africa. A mediation analysis based on the World Health Organization-Global Health Observatory data repository
Authors: Onagbiye Sunday , Ricci Hannah , Bester Petra , Ricci Cristian
Published: May 2023

Background: Globally, noncommunicable diseases (NCDs) have been continuously reported to be the number one leading cause of reduced life expectancy and poor life quality and have thus become a major public health concern.Objective: This study aimed to investigate the complex mediation analysis between physical inactivity and overweight in relation to mortality. Methods: The study is based on public data collected by the Global Health Observatory of the World Health Organization. Results: We showed that the median early mortality attributable to NCDs during the period 2016-2019 in both men and women was 23.2% (5th to 95th range=17.2, 35.6) while that in men alone was 25.1% (16.5, 45.7) and that of women alone was 22.0% (17.0, 27.9). When considering regional early NCDs mortality for both men and women, a systematically high median was observed in Southern Africa [28.7% (22.2, 43.8)] and a low median in Eastern Africa [21.1% (17.15, 27.3)]. The analysis of the overall relation between physical inactivity, overweight and early mortality due to NCDs revealed a statistical significance of the direct association between physical inactivity and early mortality due to NCDs.Conclusion: Our findings revealed three main epidemiological and public health concerns. First, early mortality attributable to NCDs in a range of about 20 to 30% across the sub-Saharan African regions for both sexes was observed. Second, there was a direct effect between physical inactivity and early NCDs mortality as well as the indirect effect mediated by overweight. Finally, a percentage point decrease in physical inactivity prevalence and overweight could effectively generate a reduction in mortality due to NCDs. Future studies are needed to confirm the scientific evidence observed in this study. Such studies should be based on observation of individual subjects, adopt a longitudinal design, and collect information that evaluates the complex relationship between physical inactivity and early NCDs mortality, along with the role of overweight as a possible mediator.
Sodium, potassium food intake and global cardiovascular risks in Togo
Authors: Kenao Tchasso S. , Sossa Jerome C. , Paraiso Moussiliou N. , Belo Mofou , Sopoh Ghislain E. , Tchankoni Kouame M. , Agueh Victoire
Published: May 2023

Objectives: To assess urinary sodium/potassium intake and identify its links with global cardiovascular risk (RCVG) according to the WHOPEN approach to WHO/ISH (International High Blood Pressure Society).Methods: It was a cross-sectional and analytical study that took place from July 6, 2020, to September 17, 2021, in Togo, in the Aneho, Notse and Dapaong localities. It focused on 400 adults selected by sampling. The analysis of two urine samples was done. Cardiovascular risk scores were determined from specific graphs that take into account age, gender, systolic blood pressure, diabetes status and smoking behavior.Results: Among the 400 respondents, 49% lived in rural areas. The average age was 41 (30; 51) years. The average sodium and potassium intakes were respectively 3.2 g (1.04-5.99) or 7.95 g of salt and 1.4 g (1.89-5.62) per day. The risk of excessive sodium intake was 2.39 times higher in urban areas than in rural ones (p=0.049). Residing in rural areas was associated with high potassium intakes compared to urban ones (OR=3,2 IC [1.89-5.62]). Thirteen percent (13%) of respondents were likely to develop at least a deadly or non-deadly cardiovascular disease in the next 10 years ‘time, of whom 5% present a high risk. Excessive sodium intake increases by 2.10 times the risk of a deadly cardiovascular disease occurrence.Conclusions: Sodium intakes are high while potassium intakes are low with a subsequent global cardiovascular risk (GCVR) in the three cities. Sodium intakes were associated with VCVR. It is necessary to take steps to reduce excessive sodium intake and improve potassium intake.
Quality of life of hypertensive men with erectile dysfunction in a tertiary health centre in southern Nigeria
Authors: Ezemenahi Silvia I. , Alabi Anthonia N. , Ogunfowokan Oluwagbenga , Nwaneli Chibundo U. , Aigbokhaode Adesuwa Q. , Eseigbe Patricia
Published: May 2023

Background: Erectile dysfunction (ED) is the most common disorder of sexual health seen in men in community studies. A man’s sexual health has been found to be a key factor in determining the capacity for maintaining a healthy relationship.Aim: This study sought to determine the quality of life of hypertensive men with ED attending the out-patient clinics of Federal Medical Centre (FMC), Asaba, South-South, Nigeria.Setting: This study was conducted in the Out Patients Clinics (OPC) of FMC, Asaba, Delta state, Nigeria.Methods: After obtaining approval from the ethics and research committees in Asaba, 184 consenting hypertensive men who met the eligibility criteria were selected by systematic random sampling to participate in the study from October 2015 to January 2016. This study was a cross-sectional survey. Data were collected with a semi-structured interviewer-administered questionnaire adopted from the international index of Sexual Health Inventory for Men (SHIM) and the World Health Organization Quality of Life Scale (WHOQOL-BREF). The study complied with the principles of Helsinki and Good Clinical Practice.Results: The results showed the mean score for physical domain (58.78 ± 24.37), the psychological domain (62.68 ± 25.93), the social domain (50.47 ± 29.09), and the environmental domain (62.25 ± 18.52). Over a fifth, 11 (22.0%), of the respondents with severe ED had poor quality of life.Conclusion: This study showed that ED is common in hypertensive men and their quality of life was more impaired than those with normal erectile function.Contribution: This study contributes to holistic approaches to patient care.
Using enterprise resource planning systems to manage property processes
Authors: Amadi-Echendu Anthea P.
Published: May 2023

Background: The various organisations that are involved in property transfer transactions tend to work as autonomous units within the end-to-end property supply chain. This compartmentalisation of activities and tasks creates inefficiencies and a lack of transparency.Objectives: There is a need to review the current paper-based processes by evaluating the end-to-end processes in their entirety.Method: Semi-structured qualitative interviews were conducted with prominent role-players involved in the property transfer process in South Africa. The general systems view was used as the theoretical underpinning of the research, whereby property processes across the property supply chain should be viewed as a single system.Results: Enterprise resource planning (ERP) systems may assist in integrating workflow processes to enhance productivity and collaboration, and improve overall property processes. The participants confirmed the need for a centralised platform with integrated workflows.Conclusion: Participants who were interviewed concurred that a centralised system would produce numerous benefits and enhanced efficiencies through a streamlined and more transparent process. Therefore, the researcher recommends that an ERP system be introduced across the property supply chain. A centralised ERP management system would enable all parties to a particular property transaction to have sight of the progress of the transaction and reduce capturing errors across various systems.Contribution: The article will be useful within the immovable property industry, as well as to the buyers, sellers, and academia. Future studies could focus on how an ERP system could be integrated into the property supply chain.
The mysterious Hebrew word שׂרקים in Zechariah 1:8
Authors: Chia Philip S.
Published: May 2023

The Hebrew word שׂרקים in Zechariah 1:8 is a mysterious word. The disappearance of the Hebrew word שׂרקים in Zechariah 1:8 from the rest of the Book of Zechariah and the unknown meaning of שׂרקים itself are the reasons for this mystery. Zechariah 1:8 does not only abandon two colours: the black horses and the spotted (dappled) horses but also this verse adds שׂרקים or the sorrel ones, which are not recorded in Zechariah 6:2–3 and 6:6–7. The appearance of שׂרקים in Zechariah 1:8, therefore, creates disagreement colours with Zechariah 6:2–3 and 6:6–7. In addition, Gelston states that the Hebrew word שׂרקים is probably unknown to the ancient translators. This unknown meaning causes different translations of שׂרקים in ancient texts. This article, thus, attempts to unveil this mystery with textual criticism as its methodology.Intradisciplinary and/or interdisciplinary implications: This research emphasises on the importance of textual criticism to unveil the unknown meaning of קים in Zechariah 1:8.
Listening between the Lines
Authors: Banerjee Priyanka , Verma Niket , Mohan Charu , Rustagi Shaifaly M. , Nair Bindu T. , Rautela Archna
Published: May 2023

Background and Aim:

Establishing good communication with patients is an essential component of good doctor–patient relationships and has a positive impact on health outcomes. A vital component of communication is nonverbal communication (NVC). NVC may reinforce or contradict our verbal comments, thereby altering the meaning of a message and its outcomes. Hence, it is imperative that medical students are made aware of NVC. The present study was undertaken to develop and implement a module for NVC skills and assess the perception of students and faculty.

Materials and Methods:

The study was conducted with students of 2nd professional MBBS. Participation was voluntary and approval was taken from the institutional ethical committee. All the contents of the module were jointly developed by the core faculty members. The module was conducted across three sessions and included role plays, exposure to simulated patients, an interactive lecture, and a focused small-group discussion. Feedback was obtained from students and faculty facilitators after conclusion of the third session.

Results:

Fifty-two students and seven faculty facilitators participated in the study. Fifty students (96%) agreed that the module was helpful in improving their NVC skills. All 52 students (100%) agreed that they felt more confident interacting with patients after attending the sessions. Forty-four students (84.6%) strongly agreed that they would attend such sessions in future also. The suitability of the module as a whole for inclusion in the curriculum was endorsed by all participants (100%). The faculty members felt that the most encouraging aspects of the module were its implementation in a nonthreatening environment, maintaining privacy during interactions with simulated patients, and self-assessment of the interaction.

Conclusion:

With regard to the feasibility and acceptability of the module, 100% of the participants and faculty facilitators agreed that the module should be included in the undergraduate curriculum.
The Lacey Assessment of Preterm Infants
Authors: Naushad Thanooja , Natarajan Meena
Published: May 2023

Background and Aim:

The Lacey Assessment of Preterm Infants (LAPI) is reported to have low sensitivity but high specificity to predict neurological function. The study objective was to find the predictive validity of the LAPI of preterm infants (LAPIs) to predict neuromotor outcomes of infants born preterm at the corrected age of 3–4 months.

Materials and Methods:

In this prospective cohort study, infants born below 35 weeks' gestation were assessed using the LAPI before their discharge from the neonatal intensive care unit. Data were collected from Latifa Hospital, Dubai. Outcome assessment was done between 3 and 4 months corrected age using Prechtl's general movement assessment (GMA) and the Test of infant motor performance (TIMP).

Results:

A total of 125 infants completed the tests (45.6% females); their mean gestational age was 30.28 (standard deviation 2.59) weeks. LAPI showed 87.50% sensitivity (95% confidence interval [CI] =47.35%–99.68%), 96.58% specificity (95% CI = 91.48%–99.06%), and 99.12% negative predictive value (95% CI = 94.75%–99.86%) in predicting fidgety movements in the GMA. The specificity and negative predictive value of the LAPI to predict the motor outcome in the TIMP was 98.06% (95% CI = 93.16%–99.76%) and 88.60% (95% CI = 84.57%–91.67%) respectively whereas sensitivity was 40.91% (95% CI = 20.71%–63.65%). Developmental score in the LAPI showed a weak correlation (P = 0.02, r = 0.20) with the TIMP score.

Conclusion:

The results suggest that the LAPI can be used to reliably predict neurological function for infants born preterm at 3–4 months corrected age. LAPI can be used as a discharge assessment tool in neonatal units to identify candidates for early intervention services.
Dual Nerve Transfer for Facial Reanimation
Authors: Rajmohan Deekshith , Sulli Deviprasad , Mohammed Jasim M. K. , Suresh Arjun
Published: May 2023

The facial nerve is the 7th cranial nerve and carries nerve fibers which control facial movement and expression. This nerve also carries fibers that are involved for the production of taste from the anterior 2/3rd of the tongue and tears from the lacrimal gland. Facial asymmetry is a debilitating condition to treat, and over the years, different techniques have been devised for improving facial asymmetry and function. Dual nerve transfer is the combination of hypoglossal nerve transfer and massetric nerve transfer. This technique is proven to correct facial asymmetry and helps restore facial tone without affecting much of tongue functionality. This case report helps understand the effectiveness of facial reanimation that was conducted on a patient with Grade VI facial nerve paralysis and follow-up after 6 months postsurgery shows drastic change in the outcome.
Evaluation of Normal Range of Maximum Mouth Opening for Pune Maharashtra Adult Population
Authors: Koranne Vaishali Vasant , Joshi Samir Achyut , Patankar Amod Pramod , Patankar Swapna Amod
Published: May 2023

Background and Aim:

Maximal mouth opening (MMO) is used as a marker of masticatory pathology. MMO varies with age, height, gender, and race. The current study is an attempt to calculate the normal range of maximum mouth opening in an adult Pune Maharashtra population.

Materials and Methods:

A total of 800 individuals, 400 males and 400 females, in the age group of 18–60 years attending outpatient department in Bharati Dental College and Hospital, Pune were randomly selected and divided into four groups according to their age ranges. In addition to the basic demographic data, MMO was measured in these individuals. The subjects were asked to open their mouth maximally until no further opening was possible. The distance from the incisal edge of the upper incisor teeth to the incisal edge of the lower incisor teeth was measured using a calibrated fiber ruler. Statistical analysis was performed.

Results:

The mean MMO for males was 50.58 (standard deviation [SD] ± 2.16) mm (Range 37–56 mm) and for females was 48.29 (SD ± 3.12) mm (Range 36–53 mm). There was a statistically significant difference between the mouth opening of male and female in all the age groups with P < 0.05 A linear relationship was observed between the mouth opening and age in both males and females and the mouth opening decreased as the age increased. In the age group of 18–29 years, the mean MMO was 54.34 (SD ± 1.84) mm. The range was 39–56 mm for males and 51.63 (SD ± 2.33) mm. with range 38–53 mm for females. In the age group of 30–39 years, the mean MMO was 52.09 (SD ± 1.72) (range 38–53 mm) and 50.07 (SD ± 2.09) (range 38–51 mm) for males and females, respectively. For the age group 40–49 years, the mean MMO was 48.94 (SD ± 1.66) mm (range 39–54 mm) for males and 46.73 (SD ± 2.84) mm (range 38–50 mm) for females. In the age group of 50–60 years, the corresponding values for males and females were 46.98 (SD ± 2.04) (range 36–50 mm) and 44.76 (SD ± 2.59) mm (range 36–49 mm).

Conclusion:

The MMO range for different age groups is established for normal adult Pune Maharashtra population.