bluuebunny/crossref_metadata_2025 huggingface dataset:
COMPARISON OF ORAL MIDAZOLAM VERSUS ORAL TRICLOFOS FOR SEDATION OF CHILDREN POSTED FOR COMPUTED TOMOGRAPHY SCAN - A RANDOMIZED CONTROLLED, DOUBLE BLIND CLINICAL STUDY
Authors:   Parekh Kutir1,1stFloor,Opposite Omkar Darshan,Masoli Tal-Dahanu Dist-Palghar 401602., Kudre Krupali , Sonkamble Poornima ,   Anesthseia Department, Main Building,6th Floor, JJ Hospital Campus, Byculla, Mumbai,400008., Panchal Shrikant ,   Parekh Kutir1 ,1stFloor,Opposite Omkar Darshan,Masoli Tal-Dahanu Dist-Palghar 401602.
Published: November 2022

Background: To maintain immobility of children for good quality computed tomography (CT) scans, sedation may be used. Present study was planned to compare the efficacy of oral triclofos and oral midazolam in children undergoing CT. Methodology: The prospective, comparative, randomized Indian study was conducted in Department of Anaesthesia at a J.J. Hospital and Grant Medical college. Study population was paediatric subjects between 2 years and 5 years (both inclusive) with ASA-I, exhibiting fearful or refractory behaviour at previous CT Scans. Oral triclofos 100 mg/kg was given to one group (100 patients) and oral midazolam 0.75 mg/kg in other group (100 patients) in preoperative room with facility of oxygen and multipolar monitor. Standardized scoring systems (Ramsay Sedation Scale, Aldrete Recovery Score) were used for evaluation. Vascular parameters, time of sedation onset and duration of recovery were also assessed. Results: Mean age and gender distribution were comparable between study groups (p>0.05). On comparing heart rate, systolic and diastolic BP between the Midazolam and Triclofos groups at all time-points, no significant difference was found (p>0.05). Mean sedation score and recovery score in the Midazolam group were found to be significantly higher compared to Triclofos group (p<0.05). Mean onset of sedation was found to be significantly quicker in the Midazolam group (p<0.05). In addition, the mean duration of sedation and duration of CT scans were significantly lower in the Midazolam group (p<0.05). Conclusion: Midazolam was found to have a better sedative profile compared to Triclofos in paediatric patients undergoing CT.
DIGITAL MENU FOR BARS AND RESTAURANTS USING AUGMENTED REALITY WITH THE AIM OF CREATING AN INTERACTIVE EXPERIENCE WITH CUSTOMER
Authors: Dos Santos Simplicio Esther , Felipe Rodrigues Leandro Joao , Mark Lobo De Oliveira Jean , Oliveira De Queiroz Daniel
Published: November 2022

AR offers immense marketing and advertising opportunities. In the right hands, AR can boost your salespeople. AR can be used in flyers, print ads, billboards, newspapers, etc. By providing a potential customer with just one QR code, you can attract multiple customers to your business. AR was used to create a digital menu for restaurants and cafeterias, so the AR application allows your customers to view the menu in a projected 3d way. Choose your favorite dish from the menu in no time with such applications. Upon entering the restaurant, the customer can open the application and check the entire menu in 3d.
THE FATE OF ALL PROTONS, FORMED IN THE 1-7 STAGES OF MITHOCHONDRIAL LOCATION AND THE EIGTH AND NINTH STAGES OF THE MEMBRANE REDOXY POTENTIAL THREE STATE DEPENDENT 9 STEPPED FULL CYCLE OF PROTON CONDUCTANCE IN THE HUMAN BODY
Authors:   New Medicine Medical University, Ulanbator, Mongolia., M. Ambaga , A. Tumen-Ulzii ,   New Medicine Medical University, Ulanbator, Mongolia., T. Buyantushig ,   New Medicine Medical University, Ulanbator, Mongolia.
Published: November 2022

We are paying a close attention to this question how decided the fate of all protons are generated in mitochondria of 50- 80 trillion cells (now by us named 1-7 stages of proton conductance) by needing another special structures, owing to which all protons have been subjected to harmless consequences by mecchanisms as maintaining serum and cell pH-7,4, packaging inside erythrocyte membrane surroundings. In connection with this, we made such elucidation as interconnection between a first 1-7 stages of proton conductance of mitochondrial location and 8-the stage of proton conductanceof Pulmonary circuit location and also, the interconnection between 8-the stage of proton conductance of Pulmonary circuit location with 9 -th stage of proton conductance of Pulmonary circuit location and interconnection between following, subsequent 1-stage of proton conductance of mitochondrial location with previous, preceding, foregoing 9-the stage of Pulmonary circuit location we have been described as eighth stage - Respiring tissue - Pulmonary circuit -oxygen uploading by bicarbonate / chloride ion shift mechanism Release of oxygen from HbO2 -under effect of exit of bicarbonate by bicarbonate / chloride ion shift mechanism, leading to increase of oxygen in a mitochondrial - 6-th stage, ninth stage - Respiratory membrane - Pulmonary circuit-increase of oxygen uptake from alveolar air - under effect of increase of bicarbonate entry by bicarbonate / chloride ion shift mechanism, leading to increase of HbO2 formation, resulting to Release of proton,electron from food substrates under the undirect action of oxygen released from membrane surroundings of erythrocyte in the 8-th stage, Transfer of proton, electron to NADH, FADH2 with release of CO2 in Krebs cycle.
A PROSPECTIVE STUDY ON THE MATERNAL OUTCOME IN CASES OF PREVIOUS ONE CESAREAN SECTION
Authors:   Associate Professor, Department of Obstetrics and Gynaecology., Sahu Bharti , a Rohini ,   PG Resident, Department of Obstetrics and Gynaecology., Tantuway Bhoomika ,   Assistant Professor, Department of Obstetrics and Gynaecology, N.S.C.B Medical College, Jabalpur Madhya Pradesh, India.
Published: November 2022

Background and Objectives:Women with previous cesarean sections constitute a high-risk group in obstetrics. The study was conducted to determine the mode of delivery in a previous cesarean section group and maternalcomplications. Method:The study was a prospective observational study conducted in The NSCB Medical College, Jabalpur from January 2020 to June 2021. Cases with previous one cesarean section for outcome in present pregnancy were taken and Cases with gestation before 28 weeks and previous section > 2 were excluded. Result:A total of 384 cases presented with the previous one CS, TOLAC was given to 109 patients (28.38%) and 51.37% achieved VBAC in the TOLAC group. Women who were selected for repeat CS without a trial of labor were 275 (71.61%)and the most common indication being scar tenderness 28%. Post-op maternal complications and infectious morbidity were significantly higher in the repeat cesarean section group. Conclusion: Women given a trial of labor with careful monitoring and taken for emergency LSCS on minimal indication is the best answer to management with an expectant attitude and individualization of labor in patients who had one cesarean section is not only justifiable but represents a sound and conservative obstetrical practice.
Conscientiousness and cognitive skills in security sphere: Associations and configurations
Authors: E. Contreras-Pacheco Orlando , Camilo Lesmez-Peralta Juan , E. Martínez-Ardila Hugo
Published: November 2022

In balancing the mission of state security forces and bodies, private security guards are expected to provide partial fulfillment to society’s sturdy desire for safety and security. They exert responsibility for protecting housing and commercial communities, as well as institutions and critical infrastructure systems, including manufacturing, utilities, transportation, and health and educational facilities. Acknowledging that these individuals must possess specific capabilities for a satisfactory level of performance, this study aims to empirically explore how those capabilities interact to obtain a good fit for their job. In order to accomplish this objective, the paper scrutinizes the insights of 94 Colombian security guards. It examines the potential associations (through a partial least squares-structural equation modeling) and configurations (through a fuzzy-set qualitative comparative analysis) between the personality trait of conscientiousness and two relevant cognitive skills: mental agility and visual memory. The findings revealed coincidences and contradictions between techniques and addressed constructs’ arrangements to understand how individual capabilities are associated with work outcomes. Even though conscientious individuals tend to perceive strong compatibility with the security job, the skills under study display signs of being contingent on obtaining the same work attachment effect. This study concludes that a security guard’s job specification must privilege the possession of a conscientiousness trait and, if possible, self-perception of proficiency in cognitive skills, such as mental agility and visual memory, to obtain a correct fitting for the job.
A modern view on the clinical value of the study of oral fluid in the practice of a pediatrician
Authors: Borisova O. V. , Makovetskaya G. A. , Gilmiarova F. N. , Selezneva I. A. , Mazur L. I. , Zhirnov V. A. , Reshetova S. N.
Published: November 2022

Currently, the attention of the medical community to a non-invasive method of laboratory diagnostics - the study of oral fluid (oral, saliva, saliva test) in various fields of clinical medicine and mainly in adult patients has been updated. Saliva testing has shown good results, especially in the areas of genomics, microbiomics, proteomics, metabolomics, and transcriptomics. The review presents the possibilities of using a non-invasive method for infectious and non-infectious diseases in children. Saliva contains a wide range of protein DNA and RNA biomarkers that help detect many viral infections in children. Oral fluid tests for human immunodeficiency virus, hepatitis B virus have improved access to diagnostics for infants. Both serological and molecular analyzes of the oral fluid are suitable for routine examination and early detection of measles virus RNA, polyomaviruses. Angiotensin-converting enzyme-2 receptor expression was found in the saliva of children with COVID-19, which can be used to diagnose SARS-CoV-2. The saliva test is as effective as the standard test at identifying asymptomatic individuals in contact tracing. The possibilities of saliva diagnostics are positively assessed in transplantology. New biomarkers in saliva have been identified for the diagnosis of many somatic diseases in children. The role of oral fluid as an alternative to blood serum in patients with terminal renal failure, chronic kidney disease (determination of creatinine, urea) in both adults and children is shown. The data obtained may influence the recommendations for the treatment of patients. As a non-invasive method, the study of oral fluid is promising for the diagnosis, prognosis, monitoring of diseases, large-scale typing of children, and the search for new biomarkers.
Efficacy of dornase alfa as part of background therapy in children with cystic fibrosis during the COVID-19 pandemic
Authors: Simonova O. I. , Gorinova Yu. V. , Chernyavskaya A. S.
Published: November 2022

In the article, the authors provided the overview of the results of international clinical studies and recent papers, as well as their own experience with the use of an enzyme mucolytic – dornase alpha in the treatment of cystic fibrosis and other chronic bronchitis affected by mucostasis. The dornase alfa has been shown to have two more non-mucolytic effects, the most important of them is anti-inflammatory one. It is the anti-inflammatory effect that plays an important role in patients with cystic fibrosis, when chronic bacterial inflammation and destruction of lung tissue take place in the pathogenesis of the disease. Dornase alpha counteracts neutrophil elastase, reducing its concentration in sputum. The authors emphasize on the fact that the same inflammatory reactions occur in covid infection and that it is dornase alfa that acts with an anti-inflammatory effect in ordinary patients, as well as in cystic fibrosis. The authors share their own experience and bring three clinical examples that demonstrate not only good tolerability and safety, but also the clinical efficacy of dornase alfa (Tigerase): in a young child when a diagnosis was established, in a teenager with a successful transition to a biosimilar after a long-term administration, and in a teenager with mucoviscidosis, who successfully managed a covid infection during therapy with this drug. The authors emphasize that dornaza alfa is now the main component of the background therapy of patients with mucoviscidosis, and its representative Tigerase may be successfully used in variously-aged children.
Diffuse agricultural pollution of groundwater: addressing impacts in Denmark and Eastern England
Authors: Foster Stephen , Bjerre Troels Kaergaard
Published: November 2022

Diffuse groundwater pollution by agricultural land-use practices is a major international problem. The evolution of the problem in two similar areas of Northern Europe, highly dependent on groundwater for public water supply and arable agriculture for economic production, is reviewed over decades through reference to some exceptionally long-term monitoring data. In Denmark, the greatest concern has been with excessive concentrations of pesticides and their metabolites but significant nitrate problems have also been experienced in some areas. In Eastern England, rising groundwater nitrate concentrations constituted the greater problem but pesticide issues also had to be confronted. An in-depth assessment of the approaches available to water utilities for addressing the problem is provided, contrasting treatment solutions, which have major implications for carbon footprint, with land-use controls, to eliminate or reduce nitrate and pesticide leaching, in groundwater source catchment areas.
Sobre o costume, as tradições inventadas e a escolarização das mulheres no Brasil
Authors: Barreto Raylane Andreza Dias Navarro , Silva Alberto Inácio da
Published: November 2022

Este trabalho tem por objetivo discutir os fundamentos e a forma como foi institucionalizado, na escola brasileira, o costume da divisão dos gêneros baseada no sexo biológico e na divisão de papeis. Metodologicamente baseado na pesquisa bibliográfica e documental, evidencia-se distintos registros a partir de leis e decretos esparsos nos últimos 200 anos que explicam as tradições inventadas dentro da escola que impõem à mulher elementos de pertença a um gênero. Teoricamente parte-se do binômio costume-tradição de Hobsbawm (2018) para desvendar as temporalidades dessa tradição. Em termos conclusivos, aponta-se os elementos que se constituíram forças preponderantes para as tradições inventadas pela e dentro da escola e que desembocaram numa educação em que as mulheres devem ser moldadas e preparadas sob a égide da superioridade masculina.
Multimodality Treatment of Deep-seated Cerebral Arteriovenous Malformations:
The Experiences of One Center
Authors: Zhang HongQi , Ji ZhenLong , Xiang SiShi , Li JingWei , Xu Jin , Yu JiaXing , Qi JiaWei , Li GuiLin
Published: November 2022

Objective:

Treatment of deep-seated cerebral arteriovenous malformations (AVMs) remains
challenging for neurosurgeons or neuroradiologists. This study aims to review the experiences
of one center in using multimodality treatment for deep-seated AVMs.

Methods:

The AVM database of Xuanwu Hospital, Capital Medical University was searched, and
96 patients who were diagnosed with a deep-seated cerebral AVM between 2010 and 2020 were
identified. The following information was collected and analyzed: patients’ clinical features, treatment
modality used, posttreatment complications, AVM obliteration rate, rebleeding rate, and functional
outcome during follow-up. The patients’ posttreatment modified Rankin scale (mRS) scores
were split into two groups: good outcome (mRS score ≤ 2) and poor outcome (mRS score ≥ 3). Univariate
and multivariate logistic regression analyses were applied to test the predictors of clinical
outcomes and AVM obliteration.

Results:

Eighty-eight out of 96 patients (91.7%) presented with initial hemorrhaging. The pretreatment
mRS score was ≤ 2 in 80 patients (88.3%) patients and ≥ 3 in 16 patients (16.7%). Limb
weakness was present in 42 patients (43.8%). In this sample, 210 hemorrhages occurred during 2056
person-years before diagnosis, yielding an annual hemorrhage rate of 10.2% per person-year. Angiographic
obliteration was achieved in 29 patients (30.2%). At the last follow-up, 80 patients (83.3%)
had good clinical outcomes, whereas 16 (16.7%) had a deterioration in their clinical presentation
following treatment. Multivariate analyses indicated that pretreatment limb weaknesses and a high
Spetzler–Martin grade predicted poor clinical outcomes (P = 0.003 and 0.008, respectively). Fewer
feeding arteries were a predictor for AVM obliteration (P = 0.034).

Conclusions:

Good outcomes can be achieved through multimodal treatment of deep-seated AVMs.
A single supplying artery is a predictor of AVM obliteration. Pretreatment limb weaknesses and
high Spetzler-Martin grades predict poor clinical outcomes.
Synthesis, Molecular Docking Analysis and In vitro Evaluation of 1,4-
Dihydroxyanthraquinone Derivatives As Anti-Trypanosomal Agents
Authors: Kisula Lydia , Siwe-Noundou Xavier , Swart Tarryn , Hoppe Heinrich C. , Mgani Quintino , Krause Rui WM
Published: November 2022

Hydroxy-substituted anthraquinones are among the most important derivatives in organic
synthesis. The attractive biological properties of these compounds are relevant to many therapeutic areas
that are of use in clinical applications. In this study synthesized several amino-substituted anthraquinones
were synthesized from 1,4-dihydroxyanthraquinone using a modified Marschalk reaction.
Moreover, 1,4,5-trihydroxyanthraquinone was synthesized from anacardic acid, an agro-waste from
the cashew industry. The in-vitro screening of the compounds against Trypanosoma brucei parasites
revealed noteworthy activity with reasonable selectivity against human cell lines. A molecular docking
study was performed to analyze the synthesized compounds' modes of interaction to the trypanothione
reductase's active site. Visual inspections examined the docked poses, and test compounds displayed
a good binding affinity with the receptor protein. This in vitro/ molecular docking evaluation
suggests that substituted 1,4-dihydroxyanthraquinone derivative can be promising starting structures
in the search for active drugs against trypanosomiasis.
Isolation and Selection of Lactic Acid Bacteria with the Capacity of
Producing γ-aminobutyric Acid (GABA) and Antimicrobial Activity: Its
Application in Fermented Meat Product
Authors: Xuan  Phong Huynh , Quoc  Viet Le , Minh  Chau Luu , Dang  Long Bui Hoang , Thanh Nguyen Ngoc , Tan Phat Dao , Truong Le Dang
Published: November 2022

Background:

γ-aminobutyric acid produced from lactic acid bacteria can be an ideal
component in food products due to its health functional properties.

Objective:

This study aimed to isolate lactic acid bacteria (LAB) with the capacity of producing
γ-aminobutyric acid (GABA) and evaluated its antimicrobial activities and application of Nem
Chua (the traditionally fermented meat product).

Methods:

LAB strains from 7 types of Nem Chua products were isolated and evaluated for their
GABA-producing and antibacterial capacities. The Nem Chua product was prepared from the selected
GABA-producing LAB strain and evaluated for its GABA content, pH, and lactic acid
levels.

Results:

Six strains (CP2, HC2, LV2, TP1, VL1, and XP1) were isolated being capable of producing
GABA (1.234 – 1.568 mg/ml) after 24 h of fermentation. Among them, the strain VL1
was found to produce the highest GABA content and induce the highest antimicrobial activity
against Bacillus Subtilis (19.7 mm in zone inhibition diameter). Strain VL1 was identified as
Lactobacillus Plantarum and was used for the production of Nem Chua, which was found to
contain 1.103 mg/g of GABA and 22 mg/g of lactic acid.

Conclusion:

The result showed the high feasibility of using GABA-producing strain L. Plantarum
VL1 to develop functional products due to its health-beneficial effects.
A CT Radiomics Analysis of the Adrenal Masses: Can We Discriminate
Lipid-poor Adenomas from the Pheochromocytoma and Malignant
Masses?
Authors: Mendi Bökebatur Ahmet Raşit , Gülbay Mutlu
Published: November 2022

Aims:

The aim of the study is to demonstrate a non-invasive alternative method to aid the
decision making process in the management of adrenal masses.

Background:

Lipid-poor adenomas constitute 30% of all adrenal adenomas. When discovered incidentally,
additional dynamic adrenal examinations are required to differentiate them from an adrenal
malignancy or pheochromocytoma.

Objective:

In this retrospective study, we aimed to discriminate lipid-poor adenomas from other lipidpoor
adrenal masses by using radiomics analysis in single contrast phase CT scans.

Materials and Methods:

A total of 38 histologically proven lipid-poor adenomas (Group 1) and 38
cases of pheochromocytoma or malignant adrenal mass (Group 2) were included in this retrospective
study. Lesions were segmented volumetrically by two independent authors, and a total of 63 sizes,
shapes, and first- and second-order parameters were calculated. Among these parameters, a logit-fit
model was produced by using 6 parameters selected by the LASSO (least absolute shrinkage and selection
operator) regression. The model was cross-validated with LOOCV (leave-one-out crossvalidation)
and 1000-bootstrap sampling. A random forest model was also generated in order to use all
parameters without the risk of multicollinearity. This model was examined with the nested crossvalidation
method.

Results:

Sensitivity, specificity, accuracy and AUC were calculated in test sets as 84.2%, 81.6%,
82.9% and 0.829 in the logit fit model and 91%, 80%, 82.8% and 0.975 in the RF model, respectively.

Conclusion:

Predictive models based on radiomics analysis using single-phase contrast-enhanced CT
can help characterize adrenal lesions.
Application of Modern Analytical Techniques for Quantification of Tadalafil
in Pharmaceutical and Biological Matrices: Future Prospectus
Authors: Kumari Acharjya Sasmita , Jana Subhadip , Nahak Anita , Kumar Dash Sanat , Chakraborty Atyurmila , Chowdhury Bimalendu
Published: November 2022

Background:

Analytical techniques play a vital role in developing patient-friendly
dosage forms in the pharmaceutical industry. Presently, numerous sophisticated and highly delicate
modern analytical instruments are available in pharmaceutical industries to assess active
pharmaceutical ingredients or other excipients present in different pharmaceutical matrices and
biological fluids. Assortment of the most suitable analytical techniques for analysing any component
during the drug development process is challenging as it affects the final product's quality,
safety, and efficacy.

Introduction:

Tadalafil (TDL) is the most flexible second-generation Phosphodiesterase-5 inhibitor.
It treats erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension
as first-line therapy, either alone or with other medications. This review paper aims to highlight
the varieties of new analytical techniques (like UV-Visible spectroscopic technique, HPLC,
HPTLC, Electroanalytical technique, Spectrofluorimetry, GC-MS, LC-MS) that have been reported
for quantification of TDL as a single or in the combined form present in bulk material as
well as in different biological or pharmaceutical matrices, their pros and cons, and future potential
of such methods.

Conclusion:

This article's reported methods are accurate, sensitive, and cost-effective. Applying
AQbD and green analytical chemistry with greener organic solvents and reagents in some of the
reported methods opens a new era of analytical method development that will aid in future
growth for the estimation of TDL.
First Report in a Human of Successful Treatment of Asthma with Mesenchymal
Stem Cells: A Case Report with Review of Literature
Authors: Sharan Joshua , Barmada Amir , Band Nicolas , Liebman Eliana , Prodromos Chadwick
Published: November 2022

Introduction:

Asthma is a heterogeneous disorder characterized by chronic airway inflammation
resulting in obstructive pulmonary symptoms. In preclinical studies, mesenchymal stem cells (MSCs)
have demonstrated the ability to ameliorate the symptoms and immunologic pathways seen in asthma.

:

Due to the known relationship between asthma and the hyper-responsive immune cascade, we hypothesized
that MSCs could be an effective treatment option for patients with asthma due to their significant
immunomodulatory properties.

Objective:

We present the initial results for the first patient enrolled in a phase 1 clinical trial (Safety of
Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intravenous Infusion for the
Treatment of Pulmonary Diseases).

Case Report:

A 68-year-old male with a longstanding history of asthma requested mesenchymal stem cell
treatment for his persistent asthma symptoms. Cultured umbilical cord-derived mesenchymal stem cells
were infused intravenously at a dose of 100 million cells over a period of 40 minutes. Post-treatment follow-
up was performed after two and six months.

Results:

The patient had no adverse events or complications related to treatment. In the two months posttreatment,
his usage of a rescue inhaler decreased to 1 time per month, over 90% reduction. In addition,
he had a 70% reduction in nebulizer usage. Improvement was sustained in the 6 months follow-up.

Conclusion:

We report the first case of mesenchymal stem cell treatment significantly and safely improving
asthma clinical symptoms in a human. Additionally, an extensive literature review provided several
plausible mechanisms by which stem cells can ameliorate immune hyper-stimulation associated with
asthma.
Impact of Newtonian Heating on MHD Micropolar Fluid for the Influence of Heat Source
Authors: Prusty K.K. , Sahoo S.N. , Mishra S.R.
Published: November 2022

Introduction:

The current analysis deals with the flow of time-independent conducting micropolar fluid past a stretching sheet. Furthermore, the influences of magnetic field strength and heat sources are also discussed in this study. The current study is important for the growing applications of magnetism in various chemical systems like pumping, transportation, trapping, sorting, separation, etc.

Aims:

In addition, the objective of the present exploration is the consideration of Newtonian heating conditions.

Methods:

Transformation of nonlinear PDEs of the flow phenomena into nonlinear coupled ODEs is done using suitable similarity variables, and these are handled by employing the “Runge-Kutta fourth-order” scheme in association with the “shooting technique”. The influence of flow characteristics proposed in this study is analyzed via graphs. The engineering coefficients for various parameters are simulated numerically and deployed through the table.

Results:

Finally, it was found that the rotational viscosity dominates over the fluid viscosity and enhances the momentum profile.

Conclusion:

An augmentation in the Prandtl number retards the fluid temperature and the application of applied magnetic field built up the resistance that retards fluid momentum.
Ab initio Valence Bond Theory with Density Functional
Authors: Zhou Chen , Wu Xun , Zheng Peikun , Ying Fuming , Su Peifeng , Wu Wei
Published: November 2022

The accurate description of strongly correlated systems, also known as multireference
systems, requires a balanced treatment of static and dynamic correlations and is an important target
for developing quantum chemical methods. An appealing treatment to economically describe
strongly correlated systems is the multireference density function theory (MRDFT) approach, in
which the static correlation is included in the multiconfigurational wave function, while the density
functional includes the dynamic correlation. This mini-review focuses on the recent progress and
applications of the density functional methods based on valence bond theory. A series of density
functional valence bond (DFVB) methods are surveyed, including the dynamic correlation correction-
based and Hamiltonian matrix correction-based DFVB methods, the hybrid one-parameter
DFVB methods, the block-localized density functional theory and the multistate density functional
theory. These methods have been applied to various chemical and physical property calculations of
strongly correlated systems, including resonance energies, potential energy curves, spectroscopic
constants, atomization energies, spin state energy gaps, excitation energies, and reaction barriers.
Most of the test results show that the density functional methods based on VB theory give comparable
accuracy but require lower computational cost than high-level quantum computational methods
and thus provide a promising strategy for studying strongly correlated systems.
Morelloflavone as Phytomedicine-An Ethnopharmacological Review on the Therapeutical Properties, Biological Efficacy and Pharmacological Activity
Authors: Patel Dinesh Kumar
Published: November 2022

Background:

Flavonoids are low molecular weight class secondary metabolites found to be present throughout the plant kingdom. Structurally, flavonoid class phytochemicals consist of C6-C3-C6 chemical structures with different substitution patterns and have drug-like nature. Morelloflavone is a biflavonoid class phytochemical found to be present abundantly in the Garcinia genus. Morelloflavone has been investigated in the scientific field for its numerous pharmacological activities. The present work aims to discuss the scientific progress of health beneficial aspects and pharmacological potential of morelloflavone in medicine.

Methods:

The purpose of this work is to provide scientific information about the biological potential and health beneficial effects of flavonoids in medicine with special reference to the morelloflavone. In this work, we have collected the scientific data of morelloflavone for the biological potential and pharmacological activities against different types of human illnesses with their mechanism of action from Google, Google Scholar, Science Direct and PubMed and analyzed. Further, the preventive role of morelloflavone against various types of human illnesses and the mechanism of action have also been discussed in the present work. This work will provide upto- date information on the health beneficial aspects of morelloflavone in medicine for the prevention and treatment of human complications.

Results:

Morelloflavone exhibited a wide-range of pharmacologic activity in regulating numerous kinds of human disorders. Present work revealed the health beneficial aspects and pharmacological activities of morelloflavone for the prevention and treatment of human disorders due to its anti-microbial, anti-plasmodial, anti-oxidant, anti-atherosclerosis, anti-inflammatory, anti-tumor anti-restenosis, anti-HIV, aphrodisiac, anti-Alzheimer's and apoptotic potential in the medicine. Further, its biological potential on phospholipase A2, melanin, kallikreins, monoamine oxidase, aromatase, Eg5 Inhibition and proprotein convertases have been also analyzed in the present work. Analytical data signified the importance of modern analytical tools for the separation and isolation of morelloflavone in medicine.

Conclusion:

Present work revealed the detailed pharmacological activities of morelloflavone that can be utilized in the future for the development of new pharmacologic agents.
Selección de hábitat y comportamiento sexual de Sulcophanaeus velutinus (Murray 1856) (Coleoptera: Scarabaeidae: Scarabaeinae) en un bosque de montaña en Colombia
Authors: Escobar Federico
Published: November 2022

Information about habitat preferences, activity and sexual behavior of Sulcophanaeus velutinus (Murray 1826), a common species of Neotropical mountains are presented.
State-of-the-Art Evidence Retriever for Precision Medicine: Algorithm Development and Validation
Authors: Jin Qiao , Tan Chuanqi , Chen Mosha , Yan Ming , Zhang Ningyu , Huang Songfang , Liu Xiaozhong
Published: November 2022

Background

Under the paradigm of precision medicine (PM), patients with the same disease can receive different personalized therapies according to their clinical and genetic features. These therapies are determined by the totality of all available clinical evidence, including results from case reports, clinical trials, and systematic reviews. However, it is increasingly difficult for physicians to find such evidence from scientific publications, whose size is growing at an unprecedented pace.

Objective

In this work, we propose the PM-Search system to facilitate the retrieval of clinical literature that contains critical evidence for or against giving specific therapies to certain cancer patients.

Methods

The PM-Search system combines a baseline retriever that selects document candidates at a large scale and an evidence reranker that finely reorders the candidates based on their evidence quality. The baseline retriever uses query expansion and keyword matching with the ElasticSearch retrieval engine, and the evidence reranker fits pretrained language models to expert annotations that are derived from an active learning strategy.

Results

The PM-Search system achieved the best performance in the retrieval of high-quality clinical evidence at the Text Retrieval Conference PM Track 2020, outperforming the second-ranking systems by large margins (0.4780 vs 0.4238 for standard normalized discounted cumulative gain at rank 30 and 0.4519 vs 0.4193 for exponential normalized discounted cumulative gain at rank 30).

Conclusions

We present PM-Search, a state-of-the-art search engine to assist the practicing of evidence-based PM. PM-Search uses a novel Bidirectional Encoder Representations from Transformers for Biomedical Text Mining–based active learning strategy that models evidence quality and improves the model performance. Our analyses show that evidence quality is a distinct aspect from general relevance, and specific modeling of evidence quality beyond general relevance is required for a PM search engine.
YouTube and its role as a complementary information strategy to combat the COVID-19 pandemic (Preprint)
Authors: Lellis Santos Rodrigo , Marques Toledo Marileila , Willya Douglas de Oliveira Dhelfeson , Da Silva Edson
Published: November 2022

BACKGROUND

The emergence of COVID-19 and the associated pandemic outbreak demonstrated the need to educate and mobilize the public to adopt behaviors for community mitigation. In a context of rapid epidemiological worsening, the use of digital media to access information benefits the population and can contribute to the control of the impact of the COVID-19 pandemic.

OBJECTIVE

This study aimed to evaluate the most viewed Brazilian videos on YouTube as a source of information about COVID-19.

METHODS

The quantitative, observational, and cross-sectional study was conducted on YouTube on 04/30/2020, with videos uploaded between 01/01/2020 and 04/ 30/2020. The descriptor “coronavirus” was used and the first 100 most viewed videos that were recorded in Brazilian Portuguese, related to the topic, unduplicated, and being less than 30 minutes long were selected. Two judges recorded the Uniform Resource Locator (URL) of the videos downloaded from YouTube for data analysis.

RESULTS

The 100 videos analyzed showed the following results: 140,027,282 views; 7,201,187 "likes"; 165,624 "dislikes"; 352,541 comments; and a total duration of 12 hours, 28 minutes, and 12 seconds. In terms of content, death was mentioned in 71 videos, and the top prevention behaviors listed by the U.S. Centers for Disease Control and Prevention were addressed by less than one-third of the videos. Most YouTube videos could do a greater job of disseminating information about COVID-19 prevention behaviors, promoting population adherence.

CONCLUSIONS

Educating, mobilizing, and engaging the public in adopting and practicing behaviors for community mitigation are differential aspects of successfully addressing the COVID-19 pandemic. Given the need for social distancing, YouTube could play an important role in interaction and communication about COVID-19 and be a significant complementary information strategy to combat the pandemic.
The Global Research Trends on Health Risk Perception and Communication: A Bibliometric Study and Visualization Analysis (Preprint)
Authors: Cao Xia , Yang Binfang , Luo Menglan , Zhou Jiansong
Published: November 2022

BACKGROUND

Globally, humans are increasingly faced with a wide variety of health risks. It is meaningful that both scholars and practitioners recognize the multifaceted nature of health risk perception and communication (HRPC). Extensive studies related to HRPC have been conducted to date. However, no bibliometric analysis has systematically investigated this issue.

OBJECTIVE

The purpose of this study was to identify the current landscape and frontier trends of scientific achievements on HRPC through bibliometric approaches.

METHODS

Quantitative analysis of publications relating to HRPC from 1999 to 2021 was interpreted and graphed through the Web of Science Core Collection database on October 21, 2022. A variety of quantitative variables was analyzed by using Microsoft Excel 2019, including publication and citation counts, H-index, and journal citation reports. Co-authorship, citation, co-citation, and co-occurrence analyses were performed for countries/regions, institutions, authors, and keywords using the VOSviewer and CiteSpace.

RESULTS

A total of 1,518 original and review articles in English were identified. The United States has considerable influence in this field, with the majority of publications (772, 50.86%), citations (23,951 times), the highest H-index (453), and close collaborations with the United Kingdom and Australia. The most contributive institution was University of North Carolina. The most productive author is Waters EA, followed by Lemyre L and Renner B. However, the relatively low level of research cooperation existed between institutions and authors. Important topics mainly include the connotations, categories, theoretical framework models, and application scenarios of HRPC. Among the promising hotspots, “Covid-19,” “pandemic,” “vaccine hesitancy,” “social media,” “e-cigarettes,” and “mental health” displayed relatively latest average appearing year.

CONCLUSIONS

Global trends indicate a growing scientific output on HRPC, and developed countries are leading the way. There is still a need to improve collaboration between research teams. The focus gradually shifts from theoretical research to empirical research. It is recommended to pay attention to the latest hot spots, such as “Covid-19,” “vaccine hesitancy,” “social media,” “e-cigarettes,” and “mental health”.

CLINICALTRIAL
Цифровая трансформация письменного наследия тибетского буддизма: состояние и перспективы
Authors:   Institute for Mongolian, Buddhist and Tibetan Studies of the Siberian Branch of the RAS (6, Sakhyanova St., 670047 Ulan-Ude, Russian Federation), Bazarov Boris V. , Rinchinov Oleg S. , Bazarov Andrei  A.
Published: November 2022

Introduction. Making public knowledge pertaining to Buddhist culture proves important and topical enough due to the steady growth of global significance attributed to East and Central Asia. Therefore, insights into monuments of Buddhist heritage represented in vast collections of Russia — at advanced academic and technological levels with an emphasis on the active use of digital technologies — shall yield solutions to quite a number of sociocultural development problems, and strengthen positions of our nation in Asia’s geopolitical environments. Goals. The study aims at analyzing the current state of the art in digitization of Tibetan Buddhism’s written heritage and assessing some promising AI related technologies development trends. Materials and methods. The study provides a comparative analysis of activities by the Buddhist Digital Resource Center (BDRC) consortium, an oldest and most successful initiatives operating since 1999, for advanced approaches in this field. The use of artificial intelligence methods to solve the problem of creating a machine-readable text corpus of Buddhist writings and machine translation is considered as a promising direction. Results. The work discloses key principles of digitization and representation of written monuments implemented on the new digital platform BUDA (Buddhist Digital Archives), shows effectiveness of the underlying IIIF (International Image Interoperability Framework) and LOD (Linked Open Data) architectures. The efforts to assess artificial intelligence technologies prospects included a pilot study on the use of ‘deep learning’ neural network methods to create an experimental model for optical recognition of Tibetan characters which yielded a result of 94 % of recognized characters. This lays a foundation for flow-line decoding of Tibetan-language scans and creating a comprehensive corpus of Buddhist writings in a machine-readable format, which offers the challenge of developing new efficient digital textual tools. Conclusions. The integration of existing and promising approaches allows for a digital transformation of Buddhist written traditions, the latter to open new functioning forms and development opportunities in the contemporary world backed with a possibility to reveal the cultural and intellectual potential of Buddhist civilization for modern society to the full.
Мемориализация подвига 110-й Калмыцкой кавалерийской дивизии в боях на Дону в июле 1942 г. в форме конных походов (май, июль 2022 г.)
Authors:   Kalmyk Scientific Center of the RAS (8, Ilishkin St., 358000 Elista, Russian Federation), Ochirov Utash B.
Published: November 2022

Introduction. The article describes two equestrian expeditions undertaken in May and July 2022 to celebrate the 80th anniversary of earliest battles for the Don attended by the 100th Kalmyk Cavalry Division. The expeditions are viewed as commemorative practices to have facilitated further memorialization of the ethnic military unit’s heroic deeds. Materials and methods. The study employs a variety of general scientific and special research techniques, including the genetic method in history, participant observations, and interviews. The work analyzes monographs and articles dealing with the 110th Cavalry Division, interviews with expedition attendees, and published media materials. Results. The paper begins with a historical review of the 110th Kalmyk Cavalry Division and describes the struggle for its historical memory. This is followed by insights into the two equestrian expeditions to have commemorated the 80th anniversary of the unit’s earliest hostilities attended. The first expedition was held on Malye Derbety – Elista route (over 200 km long), lasted for seven days, and was culminated by a ceremonial march along Elista streets on 9 May. This involved a total of approximately thirty individuals, including one young woman and five children, and was largely a preparatory arrangement to identify and settle some potential logistic and technical problems. The second expedition was organized on route Malye Derbety – Razdorskaya (over 500 km long) in July 2022 and lasted for fourteen days. The group included seventeen male individuals dressed in 1942 uniforms of Red Army cavalrymen and equipped with blank WWII firearms. The expedition was to primarily pass through Rostov Oblast and ended in Razdorskaya on 23 July during an interregional Cossack song contest. Horse riders to have attended both the expeditions would participate in public meetings and concerts to narrate about heroic deeds performed by soldiers of the 110th Kalmyk Cavalry Division. So, the early 3rd millennium equestrian tours have proved an ingenious form of patriotic propaganda and shall be long remembered — like the delivered history of the ethnic military unit proper — by participants of corresponding events. Conclusions. The arranged equestrian expeditions have served an efficient tool to memorialize heroic past of the 110th Kalmyk Cavalry Division both across Kalmykia and Rostov Oblast.
Антропологические материалы из детских погребений катакомбной культуры (по коллекции хранилища остеологических материалов Калмыцкого научного центра РАН)
Authors:   Kalmyk Scientific Center of the RAS (8, Ilishkin St., 358000 Elista, Russian Federation), Bembeeva Lyubov A.
Published: November 2022

Introduction. The article examines Middle Bronze Age (Catacomb culture) skeletal remains of children and adolescents housed at the Kalmyk Scientific Center (RAS) and attempts an evaluative insight into how informative those can be. Analyses of children and youngsters’ burials may deepen the understanding of ancient societies, actualize data on mortality and health conditions faced by non-adults. Goals. The osteological collection of Kalmyk Scientific Center (RAS) includes skeletal remains of over one and a half thousand individuals from burials dated to the Bronze Age throughout the Late Medieval Period. Nowadays the latter are being systemized, and a complete database is being compiled. The arrangements have revealed materials from children’s burials. Thematic reviews are aimed at identifying certain aspects of scholarly significance inherent to the skeletal remains repository created at Kalmyk Scientific Center (RAS) and provide additional research insights into collected anthropological materials. Materials and methods. The review involves skeletal remains of children and adolescents numbering 129. In terms of cultural chronology, the bulk of the latter come from Catacomb burials, i.e. the Middle Bronze Age. So, the work scrutinizes the mentioned cluster of remains from 43 individuals. The compiled tables describe key characteristics. Peculiarities of the selected samples are also identified, and statistical analysis proves instrumental therein. The findings are compared to data on funeral practices provided by archaeologists for wider ranges of sites. Results. The study shows that conditions of bones are fine enough for both traditional anthropological evaluations and genetic, radiocarbon, isotopic ones. The analysis of funeral practices characterizing children’s Catacomb burials concludes the latter showed no essential differences from those of adults, i.e. virtually identical are proportions of main and inlet burials, structural patterns of burial graves, and characteristics of accompanying utensils excavated.
La justificación de los derechos fundamentales titularizados por personas jurídicas
Authors: Gutiérrez Moya Carlos Daniel
Published: November 2022

The theory of the fundamental rights of legal persons is studied. Since the end of World War II, human dignity has been exalted as the foundation of all constitutional rights. Nevertheless, this is not a valid premise to explain institutional rights of legal persons and collective rights of other social groups. Professors of Constitutional Law and Court precedents, agree that institutions don’t own human dignity. Since the theory of rights necessarily includes all legal persons, the inconsistency of the model of human dignity established to justify all the constitutional rights, is clear. This investigation will explain why the projection of human dignity of the members of a social group, cannot be in all cases neither the only justification, nor the origin, of legal persons basic rights.