bluuebunny/crossref_metadata_2025 huggingface dataset:
CHANGES IN ELECTROCARDIOGRAPHIC INDICATORS OF DEPOLARIZATION AND REPOLARIZATION DURING CHEMOTHERAPY OF BREAST CANCER WITH DOXORUBICIN
Authors:   Grodno State Medical University, Grodno, Belarus, Karputs I. A. , Snezhitskiy V. A. ,   Grodno State Medical University, Grodno, Belarus, Kurbat M. N. ,   Grodno State Medical University, Grodno, Belarus, Snezhitskaya E. A. ,   Grodno Regional Clinical Cardiology Center, Grodno, Belarus, Harustovich V. A. ,   Grodno State Medical University, Grodno, Belarus, Karpovich Yu. I. ,   Grodno State Medical University, Grodno, Belarus, Rubinskij A. Y. ,   Grodno Regional Clinical Cardiology Center, Grodno, Belarus, Smirnova T. A. ,   Grodno University Clinic, Grodno, Belarus, Babenka A. S. ,   Belarusian State Medical University, Minsk, Belarus
Published: September 2024

Aim. To study changes in electrocardiographic parameters of the myocardium in patients with verified breast cancer (BC) after completion of chemotherapy (CT) with doxorubicin. Material and methods. The study included 100 patients with a confirmed diagnosis of breast cancer who were treated at the healthcare institution “Grodno University Clinic” (Grodno, Belarus). A number of electrocardiographic parameters of the myocardium were measured in patients before and after chemotherapy using electrocardiography and Holter monitoring. Based on the echocardiography data and the selected threshold value for the relative decrease in GLS (more than 12%), the subjects were divided into two subgroups: those with the presence of cardiotoxicity – CTx+ (n=19) and those without it – CTx- (n=81). Results. An increase in electrocardiographic parameters of depolarization and repolarization (P, P-Q, QRSc, J-Tc, Tpic-Tendc, Q-Tc, Q-Tdc – p<0.001; p<0.001; p=0.005; p=0.023; p=0.009; p<0.001; p=0.006, respectively), as well as in the number of supraventricular extrasystoles (p<0.001) in the general group before and after chemotherapy was detected. The J-Tc and Q-Tc intervals (longer in the CTx- subgroup compared to the CTx+ subgroup: p=0.033 and p=0.037, respectively), the number and total time of sinus tachycardia episodes (p=0.011 and p=0.010, respectively) after chemotherapy differed statistically significantly in the cardiotoxicity subgroups. Conclusions. During chemotherapy with doxorubicin, an increase in the duration of the J-Tc and Q-Tc intervals was observed, the number and duration of episodes of sinus tachycardia also increased. Assessment of the dynamics of these indicators at the stages before/after chemotherapy can provide additional information about the state of the myocardium even before identifying functional disorders by echocardiography.
THE INFLUENCE OF IRRIGATION ON THE HUMUS STATE AND FERTILITY OF MEADOW SOILS IN THE DESERT ZONE OF THE ZERAFSHAN VALLEY
Authors: Хашимов Ф.Х. , Ташкенбаев О.Н. , Кубаева М.Т.
Published: September 2024

Представляемые исследования направлены на изучение современного гумусного состояния почв Зерафшанской долины. Изучено влияние длительности орошения на качество гумуса (групповой состав) почв сероземного пояса и пустынной зоны. В данной статье показаны некоторые результаты исследований гумусного состояния гидроморфных почв пустынной зоны Зерафшанской долины отличающихся давностью орошения. На отдельно выделенных, с учетом содержания и качества гумуса, наблюдательных участках изучена взаимосвязь гумусного состояния почвы и эффективности минеральных удобрений. По мере увеличения давности орошения наблюдалось улучшение качества гумуса во всех исследуемых почвах. Длительное окультуривание орошаемых лугово-сероземных почв пустынной зоны при орошаемом земледелии, влияет не только на накопление органического вещества, но и на повышение уровня плодородия почвы, в том числе и эффективность использования сельскохозяйственными растениями элементов питания из вносимых в эти почвы минеральных удобрений.

The purpose of the work is to study the current humus state of soils in the Zerafshan Valley. The influence of irrigation duration on the quality of humus (group composition) of soils in the grey earth soil belt and desert zone was studied. This article shows some results of studies of the humus state of hydromorphic soils in the desert zone of the Zerafshan valley, differing in the age of irrigation. At separately selected observation sites, taking into account the content and quality of humus, the influence of the humus status of the soil on the effectiveness of mineral fertilizers was studied. As the duration of irrigation increased, an improvement in the quality of humus was observed in all studied soils. Long-term cultivation of irrigated meadow-grey soils of the desert zone during irrigated agriculture affects not only the accumulation of organic matter, but also an increase in the level of soil fertility, including the efficiency of agricultural plants using nutrients from mineral fertilizers applied to these soils.
Constrained TACC3 peptidomimetics for a non-canonical protein-protein interface elucidate allosteric communication in Aurora-A Kinase
Authors: Gimenez Diana , Walko Martin , Miles Jennifer , Wright Megan , Bayliss Richard , Andrew Wilson
Published: September 2024

Peptidomimetic design for non-canonical interfaces is less well established than for α-helix and β-strand mediated protein-protein interactions. Using the TACC3/Aurora-A kinase interaction as a model, we developed a series of constrained TACC3 peptide variants with 10-fold increased binding potencies (Kd) towards Aurora-A in comparison to the parent peptide. High-affinity is achieved in part by restricting the accessible conformational ensemble of the peptide leading to a more favourable entropy of binding. In addition to acting as potent orthosteric TACC3/Aurora-A inhibitors, these peptidomimetics were shown to activate the kinase and inhibit the N-Myc/Aurora-A interaction at a distal site. Thus, the potency of these tools uniquely allowed us to unveil new insight into the role of allosteric communication in the kinase.
PathInHydro, a set of machine learning models to identify unbinding pathways of gas molecules in [NiFe] hydrogenases
Authors: Sohraby Farzin , Guo Jing-Yao , Nunes-Alves Ariane
Published: September 2024

Machine learning (ML) is a powerful tool for the automated data analysis of molecular dynamics (MD) simulations. Recent studies showed that ML models can be used to identify protein-ligand unbinding pathways and understand the underlying mechanism. To expedite the examination of MD simulations, we constructed PathInHydro, a set of supervised ML models capable of automatically assigning unbinding pathways for the dissociation of gas molecules from the [NiFe] hydrogenases, using the unbinding trajectories of CO from Desulfovibrio fructosovorans [NiFe] hydrogenase as a training set. [NiFe] hydrogenases are receiving increasing attention in biotechnology due to their high efficiency in the generation of H2, which is considered by many to be the fuel of the future. However, some of these enzymes are sensitive to O2 and CO. Many efforts have been made to rectify this problem and generate air-stable enzymes by introducing mutations that selectively regulate the access of specific gas molecules to the catalytic site. Herein, we showcase the performance of PathInHydro for the identification of unbinding paths in different test sets, including various gas molecules and a different [NiFe] hydrogenase, which demonstrates its feasibility for the trajectory analysis of a diversity of gas molecules along enzymes with mutations and sequence differences. PathInHydro allows the user to skip time-consuming manual analysis and visual inspection, facilitating data analysis for MD simulations of ligand unbinding from [NiFe] hydrogenases. The codes and data sets are available online: https://github.com/FarzinSohraby/PathInHydro.
Comment on "Structure of a novel form of carbon: dehydropolycondensed adamantane?" by J. S. Rigden, K. J. Koivusaari, R. J. Newport, D. A. Green, G. Bushnell-Wye and J. Tomkinson, J. Mater. Chem. 1996, 6, 449.
Authors: Armstrong David , Fekl Ulrich
Published: September 2024

This comment addresses the identification of the crystalline phase observed after Wurtz-Fittig coupling (using sodium) and heat treatment of 1,3,5,7-tetrabromoadamantane in J. S. Rigden, K. J. Koivusaari, Robert J. Newport, D. A. Green, G. Bushnell-Wye and J. Tomkinson, J. Mater. Chem. 1996, 6, 449, where a preparation intended to yield "dehydropolycondensed adamantane" (V. I. Kasatochkin, Y. P Kudryavtsev, V. M. Elizen, O. I. Egorova, A. M. Sladkov and V. V. Korshak, Dokl. Akad. Nauk. USSR 1976, 231, 1358) was re-investigated. Using powder X-ray diffraction (P-XRD), the crystalline phase in question was assigned by Ridgen et al. in 1996 to be a carbon-based "graphitic" material. We show here that this assignment is incorrect. A direct comparison of the P-XRD pattern reported in 1996 with the P-XRD pattern generated from the sodium bromide structure reveals that the crystalline phase observed is in fact sodium bromide (NaBr).
Modeling Ligand Binding Site Water Networks with Site-Identification by Ligand Competitive Saturation: Impact on Ligand Binding Orientations and Relative Binding Affinities
Authors: Kumar Anmol , Goel Himanshu , Yu Wenbo , Zhao Mingtian , MacKerell Alexander D.
Published: September 2024

Appropriate treatment of water contributions to protein-ligand interactions is a very challenging problem in the context of adequately determining the number of waters to investigate and undertaking the conformational sampling of the ligands, the waters, and the surrounding protein. In the present study, an extension of the Site Identification by Ligand Competitive Saturation-Monte Carlo (SILCS-MC) docking approach is presented that enables determination of the location of water molecules in the binding pocket and their impact on the predicted ligand binding orientation and affinities. The approach, termed SILCS-WATER, involves MC sampling of the ligand along with explicit water molecules in a binding site followed by selection of a subset of waters within specified energetic and distance cutoffs that contribute to ligand binding and orientation. To allow for convergence of both the water and ligand orientations, SILCS-WATER is based on just the overlap of the ligand and water with the SILCS FragMaps and the interaction energy between the waters and ligand. Results show that the SILCS-WATER methodology is able to capture important waters and improve ligand binding orientations. For 6 of 10 multiple-ligand protein systems the method improved relative binding affinity prediction against experimental results, with substantial improvements in three systems, when compared to standard SILCS-MC. Improved reproduction of crystallographic ligand binding orientations is shown to be an indicator of when SILCS-WATER will yield improved binding affinity correlations. The method also identifies waters interacting with ligands that occupy unfavorable locations with respect to the protein whose displacement through the appropriate ligands modifications should improve ligands binding affinity. Results are consistent with the binding affinity being modeled as a ligand-water complex interacting with the protein. The presented approach offers new possibilities in revealing water networks and their contributions to the binding orientation and affinity of a ligand to a protein and is anticipated to be of utility for computer-aided drug design.
A Filosofia Hebraica de Franz Rosenzweig
Authors: GUARNIERI MARIA CRISTINA MARIANTE
Published: September 2024

Franz Rosenzweig (1886-1929) é consideradopor muitos autores como um grande expoente dopensamento judaico. Iniciou seus estudos em medicina,mas aos vinte anos assume seu interesse porhistória e pela filosofia e, em 1908, inicia a sua tese dedoutorado sobre a filosofia de Hegel. Paralelamente Ã spesquisas sobre Hegel, Rosenzweig experimenta apossibilidade de converter-se ao cristianismo, masdescobre nessa busca que essa conversão não eramais necessária. Começa a seguir os cursos deHermann Cohen com o intuito de redescobrir o significadodas raízes judaicas. Este é o início de suareflexão sobre a questão teológica: um “novo pensamento”que possui como categoria fundamental aRevelação. Rosenzweig utiliza o judaísmo comométodo, o que faz dele um pensador religioso; seupensar sobre o problema teológico busca, conceitualmente,uma direção menos dependente da Grécia.Nossa intenção nesse ensaio é tratar do encontroentre filosofia e teologia no pensamento de FranzRosenzweig e seus desdobramentos na questão doconhecimento.
Uma saída do dilema de Eutífron
Authors: ZANGWIL NICK
Published: September 2024

Defendo a visão de que a moralidade depende deDeus, contra o dilema de Eutífron, argumentando queas razões de Deus para determinar dependênciasmoral-naturais podem ser razões pessoais que têmconteúdo não moral. Eu evito a preocupação do“capricho arbitrário”, mas concedo que a explicaçãonão se estenda Ã  bondade de Deus e sua vontade.Entretanto, dependências moral-naturais humanaspodem ser explicadas pela vontade de Deus. Então,uma versão ligeiramente restrita da teoria docomando divino é defensável.
É Possível Discutir Ética a Partir de Temor e Tremor? Possíveis Objeções a Teses Kierkegaardianas e seus Desdobramentos
Authors: DE PAULA MARCIO GIMENES
Published: September 2024

A história de Abraão - e a ordem divina para osacrifício do seu filho Isaac ”“ é, como muitos de nóssabemos, a fonte de inspiração para algumas reflexõesde Kierkegaard em Temor e Tremor. A partir de talepisódio, Johannes de Silentio, o pseudonímico autorda obra, além de fazer uma ode Ã  fé como a mais altadas paixões, questiona-se também acerca de umproblema que, segundo sua interpretação, parececentral, isto é, a suspensão teleológica da ética. Assim,o objetivo do presente artigo é investigar,notadamente a partir das reflexões de Kierkegaarduma possível interpretação para a suspensãoteleológica da moral, em que circunstâncias tal coisaefetivamente ocorre e como podemos inseri-la nosdebates éticos da filosofia do século XIX.
НЕКЛАССИЧЕСКИЕ И СКРЫТЫЕ СИММЕТРИИ НЕЛИНЕЙНЫХ АЛГЕБРАИЧЕСКИХ УРАВНЕНИЙ И СИСТЕМ
Authors: Полянин А. Д. , Шингарева И. К.
Published: September 2024

Рассматриваются классические и неклассические симметрии алгебраических уравнений и систем алгебраических уравнений. Описаны преобразования, сохраняющие вид некоторых алгебраических уравнений, а также преобразования, понижающие степень этих уравнений. Показано, что отдельные алгебраические уравнения, имеющие скрытые симметрии, путем введения новой дополнительной переменной могут сводиться к классическим симметрическим системам алгебраических уравнений. Установлено, что симметрические системы алгебраических уравнений смешанного типа, состоящие из симметрических и антисимметрических многочленов, можно преобразовать к более простым системам. Излагается метод решения неклассических симметрических систем двух алгебраических уравнений, которые меняются местами при перестановке неизвестных. Исследуются алгебраические уравнения, содержащие вторую итерацию заданного многочлена, которые сводятся к неклассическим симметрическим системам уравнений. Приведены примеры решения конкретных алгебраических уравнений и систем таких уравнений, допускающих явные и скрытые симметрии. В частности, рассматриваются нетривиальные алгебраические уравнения шестой и девятой степени, содержащие свободные параметры, которые допускают решения в радикалах. Описаны иррациональные уравнения, которые путем введения двух новых переменных сводятся к симметрическим системам алгебраических уравнений.
Modeling and Simulation of Two Plates Connected Via a Single Riveted Lap-Joint
Authors:   Mechanical Engineering Department, Faculty of Engineering, University of Zawia, Zawia, Libya, Ehmaida Mutyaa , Alsaeh Raghed Asaied ,   Mechanical Engineering Department, Faculty of Engineering, University of Zawia, Zawia, Libya
Published: September 2024

Rivets and riveted lap joints are important mechanical fasteners that are used in a large variety of applications, and their performance depends on many parameters. The goal of this study is to model and simulate two plates joined together by a riveted lap joint. Four configurations were used, which are 2-vertical, 2-horizontal, 4-inline and 4-staggered configurations, and diameters of 0.2 cm to 0.4 cm were also used. The plate was subjected to forces ranging between 2000 N to 8000 N. Results have shown that the 4-inline configuration was the best due to its lower stresses than the other configurations, followed by the 2-vertical configuration. The 2-horizontal and 4-staggered configurations had the worst performance and had similar performance. Stresses produced by the forces had a linear relationship with the magnitude of force. Finally, the results showed that the best rivet design was the 4-inline configuration with a diameter of 0.4 cm, since increasing the diameter beyond that had a much lower benefit.
Numerical Investigation of Heat Transfer Enhancement of Turbulent Flow in Dimpled Tubes
Authors:   Department of mechanical engineering, Faculty of Engineering, University of Zawia, Libya., Omer Elhassen Ali Ahmed , Alkharboushi Ali Ali Khalifa ,   Department of mechanical engineering, Faculty of Engineering, University of Zawia, Libya.
Published: September 2024

The importance of heat transfer enhancement has gained greater significance in many engineering applications, and a great amount of effort has been devoted to the use different techniques to improve the thermal performance of flowing fluids in pipes. Dimpled tubes were used for this purpose in this study. In this investigation, the heat transfer-flow characteristics of turbulent flow in dimpled tubes subjected to uniform heat flux are numerically investigated. The rate of heat transfer, friction factor, and performance evaluation criterion were determined for various designs of dimpled tubes and compared with smooth tubes. The considered cases are conducted in the Reynolds number range of 3000 to 12,000. The ANSYS Fluent R19 is used for this purpose. The Reynolds-averaged Navier-Stokes equations(RANS) are used to model the governing flow equations. The realizable k-ε turbulence model is used with enhanced wall conditionsto simulate turbulent flow adjacent to the inner wall surface. The results revealed that the rate of heat exchange in dimpled tubes higher than that of smooth ones. but with additional pressure loss. Moreover, the heat transfer performance of the staggered arrangement is higher than the inline arrangement by 17 %. Also, the performance evaluation criteria (PEC) increases with the increasing in dimples diameter, and decreases with increasing in relative pitch spacing, the maximum enhancement reaches 31% for d = 5 mm, and relative pitch spacing S/D = 2 at Re = 4000.
The Effects of Web-Based Technologies on knowledge Sharing
Authors:   Faculty of Information and Technology, Wadi Alshatti University, Brack, Libya, Abuazoum Abdusalam Abdulazez Abdulla
Published: September 2024

The main issue in Web-based technologies is on how to differentiate and create many fresh opportunities. Internet portals represent an extension of knowledge sharing (KS) for users. In a contemporary knowledge-intensive economy, knowledge is considered a fundamental strategic resource for individuals and a source of sustainable competitive advantage. By sharing existing knowledge from a web based domain to a target such as retention, individuals can learn about a company’s products/services. The findings of this study provide useful information and could help organizations managers motivate their employees to engage in KS practices by Web-based technologies. The main finding of this study is that content quality, service quality, systems quality have a positive effect on KS among the employees of organization.
Bambara groundnut as a food, nutritional and income security crop in SubSaharan Africa
Authors: Siwale J. , Gerrano A.S. , Mbuma N. , Labuschagne M.
Published: September 2024

An over-reliance on the three major global food staples; maize, wheat, and rice, to
continue feeding the world is a dangerous approach. Bambara groundnut originated in
West-Africa, but was adopted in many African countries, and is produced almost
exclusively by small-scale farmers. It has good levels of nutrients, particularly protein,
carbohydrates and fat, as well as lysine, in such a balanced manner that it has been termed
a “complete food”. The long duration of cooking (hard-to-cook) of bambara groundnut,
and the low number of uses in food preparation (in contrast to groundnut) are also factors
responsible for lower levels of production and utilization compared to other legumes.
Bambara groundnuts have more than 20% protein and can be used as a meat supplement
or replacer. It also has high levels of iron and zinc. Landraces with dark-coloured seeds
such as red or black, generally contain higher levels of nutrients and minerals than the
cream-white or plain-white coloured landraces. The iron content of red bambara seeds was
found to be double that of cream-coloured seeds. Antinutrients such as phytic acid can
reduce the bioavailability of iron and zinc, but dehulling of the seed can reduce
antinutrients significantly. Bambara groundnut has significant potential as a food security
crop, but concerted efforts should be made by governments to market the crop, and to
develop products and new uses for the seed and the plant. Plant breeding efforts can
improve yield and cooking quality. This paper presents progress on the industrial
application for food and nutritional security and genetic improvement of bambara
groundnut through breeding.
Oyun Temelli İş Tasarımı (Playful Work Design) Ölçeğinin Türkçe Uyarlaması: Geçerlilik ve Güvenilirlik Çalışması (Turkish Version of the Playful Work Design Scale: Validity and Reliability Study)
Authors: Çağlın Cahit
Published: September 2024

Bu çalışmada Scharp ve diğerleri (2019) tarafından geliştirilen oyun temelli iş tasarımı ölçeğinin Türkçe uyarlamasının yapılması amaçlanmıştır. Oyun temelli iş tasarımı, iş tasarımı konusunda geliştirilen oldukça yeni bir kavram olup temeli oyun kavramına dayanmaktadır. Söz konusu kavram, çalışanın proaktif bir yaklaşımla iş faaliyetlerinin ilgili olan herkes için eğlenceli olması amacıyla işin özünü değiştirmeden iş faaliyetlerine eğlenceyi katması veya kendi kendisiyle rekabet etmek suretiyle işini daha ilginç ve keyif verecek şekilde tasarlamasıdır. Araştırma Şırnak ilinde kamu veya özel sektörde çalışan 422 kişiden elde edilen verilerle yürütülmüştür. Elde edilen veriler SPSS ve AMOS programlarında kullanılmak üzere kodlanmıştır. Keşfedici ve doğrulayıcı faktör analizleri sonucunda ölçeğinin orijinal yapısındaki gibi eğlenceyi tasarlama ile rekabeti tasarlama olarak iki boyutlu yapıya sahip olduğu elde edilmiştir. Türkiye’deki iş yaşamında çalışanların oyun temelli iş tasarımı düzeyini belirlemede ölçeğin kullanılabileceği belirlenmiştir.
Turizm İşletmelerinde İş Yaşam Dengesi Araştırmalarına Yönelik Bibliyometrik Bir Analiz (A Bibliometric Analysis of Work-Life Balance Research in Tourism Organisations)
Authors: Solmaz Cansu
Published: September 2024

Bu araştırmada turizm alanyazınındaki iş-yaşam dengesi araştırmalarının kavramsal, entelektüel ve sosyal yapısının ortaya konulması amaçlanmıştır. Bu doğrultuda bibliyometrik analiz yönteminden yararlanılmıştır. Web of Science ve Scopus veri tabanından elde edilen 153 çalışma, R programında bibliometrix paketi kullanılarak analiz edilmiştir. Bulgular iş-yaşam dengesinin en çok; iş ve yaşam tatmini, örgütsel bağlılık, presenteizm, iş performansı, iş stresi, tükenmişlik ve işten ayrılma kavramları ile ilgisinin araştırıldığını göstermiştir. İş-yaşam dengesi araştırmalarda, sıklıkla iş-yaşam çatışması boyutuyla ele alınmıştır. İş-yaşam etkileşiminin bireysel boyuttaki belirleyicileri ve sonuçları, iş-aile zenginleşmesi, iş-yaşam dengesinin misafirler üzerindeki etkileri, iş-yaşam pratikleri, iş yaşam dengesinde cinsiyet araştırmaları gibi konuların gelişim potansiyeli taşıyan temalar olduğu tespit edilmiştir. Bu çalışmanın, yazarın bilgisi kadarıyla ulusal alanyazında turizm işletmelerinde iş-yaşam dengesi çalışmalarını bibliyometrik analiz yöntemi ile inceleyen ilk çalışma olması dolayısıyla alana katkı sağlaması beklenmektedir.
Adaptação do diagrama heurístico como ferramenta de apoio à resolução de casos investigativos no Ensino de Química
Authors: Da Costa Paz Cleane , De Sousa Barbosa Herbert , Nobre de Abreu Ferreira Luciana
Published: September 2024

Este artigo tem por objetivo analisar a adaptação do diagrama heurístico como ferramenta didática na resolução de Casos Investigativos (CI). Para isso, o lado do diagrama correspondente à parte metodológica foi modificado com a inserção de elementos do modelo de tomada de decisão, tais como: geração de alternativas, avaliação e escolha da solução. As modificações do instrumento foram interpretadas e discutidas à luz da metodologia do programa de investigação científica. Para ensaio e discussão dos resultados, foi elaborado um diagrama com a solução de um CI. Com a análise, identificamos hipóteses, heurística positiva e heurística negativa, no diagrama, as quais permitem explicar a dinâmica da ciência e a construção do conhecimento científico. Os resultados indicam que os elementos inseridos no diagrama orientam para aspectos pertinentes à resolução do CI e construção do conhecimento. Ademais, o diagrama adaptado é uma boa ferramenta didática à resolução de CI.
The Positive Side of Perfectionism: Examining the Role of Perfectionism in Driving Safety Performance and Change-oriented Organizational Citizenship Behaviors
Authors:   Korean Academy Of Management, Lee Sangwon , Kang Dae-seok
Published: September 2024

This study examined the positive side of perfectionism and its effect on employees’ safety performance and change-oriented organizational citizenship behavior (OCB-CH). For this purpose, we proposed a moderated mediation model in which feedback-seeking behavior (FSB) was theorized as a mediating mechanism underlining why workers are involved in those discretionary behaviors from their perfectionism. Moreover, each recognition and appraisal form of respect was assumed to be a relevant boundary condition to moderate such relationships. Data were collected using a field survey research design. The participants included 213 workers at construction sites and manufacturing plants, along with military personnel and firefighters, all of which are regarded as high-risk occupations in Korea. SPSS 25, AMOS 22, and PROCESS macro were used to analyze the data. The findings revealed that perfectionism impacts both safety performance and OCB-CH directly and through their FSB. Meanwhile, perceived mutual recognition respect negatively moderates the relationship between perfectionism and FSB, whereas perceived appraisal respect has no moderating effect. There may be a trade-off relationship between safety and change. Through offering a perfectionism-FSB link, the results of this study provided an understanding of positive perfectionism as a desirable personality trait that potentially engenders those discretionary behaviors. We further discussed the theoretical and practical implications of the findings and identified directions for future research.
Digital Marketing melalui Instagram Dalam Membangun Jalur Pelanggan Pada Rumah Impi Kreatif Di Kota Makassar
Authors: Caezar To Tadampali Andi
Published: September 2024

Digital Marketing menjadi alat penetrasi pasar yang sangat diperlukan bagi pengusaha atau perusahaan diera digitalisasi saat ini untuk menjangkau calon pelanggan secara luas. Media sosial khususnya instagram merupakan salah satu  alat penerapan strategi digital marketing yang sangat populer dan sangat sesuai untuk membangun jalur pelanggan. Penelitian ini menjelaskan terkait strategi digital marketing melalui instagram sebagai media membangun jalur pelanggan dengan menggunakan metode kualitatif deskriptif. Penelitian ini menggunakan teknik studi literatur untuk mendapatkan data serta referensi. Berdasarkan hasil yang didapatkan diketahui bahwa penerapan digital marketing melalui instagram yang bertujuan untuk membangun jalur pelanggan sangat efektif dan efisian digunakan.
Pengaruh Desain Produk dalam Minat Beli konsumen untuk Meningkatkan Penjualan Pada Prodak Miniso
Authors: Mardatillah Andi Mahdiana
Published: September 2024

Penelitian ini bertujuan untuk mencari seberapa besar pengaruh desain produk  dalam meningkatkan penjualan dan minat beli konsumen pada prodak miniso . penelitian ini di lakukan untuk mengukur seberapa besar pengaruh desain produk dlama minat beli konsumen karena saat ini konsumen tertarik membeli sesuatau karena desainya bukan fungsi, jenis pengumpulan data pada obyek penelitian, untuk menganalisis data tersebut dinamakan dengan menggunakan metode pengumpulan data deskripsi secara kuantitatif. hasil penelitian ini di dapat  Berdasarkan hasil pengolahan data  dapat diketahui bahwa hasil penjualan di miniso tiap triwulan di tahun 2023 megalami peningkatan, variabel desain produk dan kualitas produk menunjukkan penjualan mengangalami peningkatan Maka dapat disimpulkan bahwa variabel desain produk dan kualitas produk berpengaruh positif dan signifikan terhadap keputusan pembelian.  Laba kotor mencapai RMB1.161,7 juta (US$169,2 juta), meningkat sebesar 64,4% dari tahun ke tahun  Hаsil pеngujiаn mеnunjukkаn tеrdаpаt pеngаruh positif dаn signifikаn dаri kemasan produk dalam peningkatan penjualan Brаnd Miniso. Hаsil pеnеlitiаn ini dihаrаpkаn dаpаt mеnjаdi аcuаn bаgi pеnеliti sеlаnjutnyа. Pеnеlitiаn yаng sеrupа dаpаt dikеmbаngkаn mеnggunаkаn vаriаbеl-vаriаbеl аtаu objеk yаng bеrbеdа. Hаl ini ditujukаn аgаr tеrdаpаt hаsil pеnеlitiаn yаng lеbih vаriаtif dаri pеngаruh Dеsаin Kеmаsаn Produk Tеrhаdаp Kеputusаn Pеmbеliаn Dаn Dаmpаknyа peningkatan pendapatan penjualan
Slightly (τ1, τ2)p-Continuous Multifunctions
Authors: Viriyapong Nongluk , Sompong Supannee , Boonpok Chawalit
Published: September 2024

Our main purpose is to introduce the concepts of upper and lower slightly (τ1, τ2)p-continuous multifunctions. Moreover, several characterizations of upper and lower slightly (τ1, τ2)p-continuous multifunctions are investigated.
METHODOLOGY OF ASSESSMENT AND MANAGEMENT OF THE DEVELOPMENT OF SOCIO-ECONOMIC MESOSYSTEMS
Authors:   Russian State University for the Humanities, Shamsutdinova Marina R.
Published: September 2024

The article is focused on the consideration of the concept of mesosism in the context of management by socio-economic development. It also provides a methodology for assessing and managing the development of socioeconomic mesosystems. The article proposes a number of methods that will allow assessing the level of development of socio-economic systems for further development of measures to improve their management efficiency. Systemic economics considers the concept of “mesoeconomics” mainly in the context of the economic sphere, focusing on the regional dimension [Kleiner 2006]. At the same time, it is advisable to expand the conceptual framework to include the following aspects in the field of mesoeconomics research: – Industry clusters and ecosystems – groups of interconnected enterprises and organizations united by a single industry specialization, common technologies and markets; – Local economic systems – autonomous territorial entities with their own resources, production base and infrastructure, but interacting with the external environment; – Global value chains – networks of interconnected enterprises and organizations engaged in joint activities for the production and distribution of goods and services on a global scale. The development of the theoretical foundations of mesoeconomics will allow not only to study, but also to manage those objects, contributing to an increase in the efficiency of the economic system as a whole. It will require the involvement of an interdisciplinary approach combining methods of systems analysis, economics, sociology and other sciences. Thus, mesoobjects take the modern economy beyond the neoclassical paradigm, opening up new horizons for research and practical application. The system economy, expanded on the basis of the proposed concepts, serves as a promising theoretical basis for building mesoeconomical models and developing effective management mechanisms.
THE ROLE OF THE BANK OF RUSSIA IN PROTECTING THE RIGHTS OF CONSUMERS OF FINANCIAL SERVICES
Authors:   Russian State University for the Humanities, Samoilova Valentina V.
Published: September 2024

In modern conditions with the variety of forms and types of financial products and services offered on the market, as well as many organizations offering them to clients, a special role is played by the activities of the Bank of Russia aimed at protecting the rights of consumers of financial products and services, preventing violations of those rights, as well as increasing the level of financial literacy of the population. The reactive and preventive activities of that Bank in that area make it possible to effectively address the issue of customer rights violations.
MANAGEMENT EFFICIENCY IN CONDITIONS OF POLITICAL AND ECONOMIC TURBULENCE
Authors:   PJSC “Tehpribor”, Guryanova Darina A. , Plotnikov Vladimir A. ,   St. Petersburg University of Management Technologies and Economics
Published: September 2024

The article considers discusses the issues of effective business conduct in conditions of growing uncertainty in the business environment. In recent years, that uncertainty has increased sharply, which is determined, in particular, by two successive macroshocks (pandemic, 2020 and sanctions, 2022), which gave rise to poorly predictable changes in the Russian economy. The authors define the situation as political-economic turbulence. Political and economic turbulence in general negatively affects the efficiency of management in the economy, which is confirmed by available statistical data. At the same time, there are numerous counterexamples when, even in a turbulent environment, due to effective management it is possible to obtain high results in economic activity. It is shown that the current economic conditions require a revision of management approaches. Renewed management must be focused on protecting against the risks caused by turbulence, while at the same time taking advantage of the new opportunities it generates. In that regard, it is recommended to more actively use the project approach in management. The formation of a portfolio of projects balanced in terms of risks and performance allows economic systems to successfully function and develop even in conditions of political and economic turbulence.
FAKE NEWS DETECTION USING MACHINE LEARNING MULTI-MODEL METHOD
Authors: Sahu Laxminarayan , Narain Bhavana
Published: September 2024

A fake news article that originates from an WhatsApp source is known as fake news. Fake news is becoming more and more prevalent on social media and other platforms, and this is a serious worry since it has the potential to have devastating effects on society and the country. This is why there has already been a lot of research done on its detection. This study uses supervised machine learning techniques to develop a product model through research and implementation of false news detection system. To put it briefly, this work will use a Naive Bayes classifier to build a model that can identify fake news by measuring its words and phrases against a set of criteria. that uses techniques like a count vectorizer (using word tallies) or a (Term Frequency Inverse Document Frequency) tfidf matrix to categorize bogus news as real or false It's highly likely that the meaning of two papers with comparable word counts will be entirely different.
AN EXPLORATORY STUDY ON SAMBALPURI DANCE AND MUSIC
Authors: Nath Nibedita , Mishra Supreeti
Published: September 2024

Dance and music are integral part of the cultural heritage of any community. The objective of the paper is to explore the different types of music and musical instruments used in Sambalpuri folk dance; to describe the different types of Sambalpuri folk dance and to throw light on the changes that are taking place in Sambalpuri music and dance due to several factors.The present study is exploratory and descriptive in nature.Data for the study was collected from both primary sources and secondary sources. Primary data were collected from the musicians, dancers, and dance teachers of Sambalpur district. Samples for the study were selected through the snowball sampling method.The findings of the study have been discussed under three sections. The first section describes the musical instruments associated with Sambalpuri folk dance. The second section deals with the different types of Sambalpuri folk dance. The third section deals with changes that are taking place in Sambalpuri music and dance in courser of time due to several factors.
O Projeto de Design e suas convergências com a Pesquisa Etnográfica
Authors: Passos Ravi Figueiredo , Oliveira Jacqueline Alves de
Published: September 2024

A busca pela compreensão sobre o sujeito e suas relações com o meio - seja no plano material ou digital - e os artefatos que o compõem motiva esta pesquisa, que tem como objetivo relacionar as características, ferramentas e direcionamentos da pesquisa etnográfica ao percurso metodológico do projeto de design. Assim, o presente estudo utilizou-se de um levantamento bibliográfico e análise crítica para aplicar conceitos da etnografia - em particular, da etnografia digital - a uma abordagem metodológica de design a fim de coletar informações com maior precisão sobre os usuários do artefato de design, de modo a contribuir com o desenvolvimento de projetos da área. Como resultado, apresenta-se um conjunto de sugestões sobre desenvolvimento da abordagem por meio da identificação de etapas e ferramentas aderentes à sistematização de uma abordagem metodológica.
Análise da IAG aplicado ao Design: fases de desenvolvimento, ensino e questões éticas
Authors: Farias Bruno Serviliano Santos , Silva Inez Maria Leite da
Published: September 2024

O artigo analisa a evolução da Inteligência Artificial Generativa (IAG), seguindo o modelo de Bonsiepe para discutir seu desenvolvimento e integração nas práticas de design e repercussões no ensino. Salienta a persistência de desafios éticos e sociais, ressaltando a necessidade de uma abordagem crítica e adaptativa no uso da IAG. O texto sublinha a importância de atualizar modelos educacionais e práticas de design para alinhá-los com os avanços tecnológicos, enfatizando a necessidade de manter um pensamento crítico e ético diante das inovações tecnológicas.
Hipnotizados: uma revisão exploratória sobre crianças e tempo de tela
Authors: Vilarinhos Debora Teixeira , Silva Tiago Barros Pontes e
Published: September 2024

O design da informação para interfaces digitais tem se popularizado pelos tópicos de experiência do usuário. Ao investigar a literatura da área, vê-se nas interfaces a intenciolalidade de captar ao máximo a atenção do usuário, reduzir seu esforço e, por conseguinte, mantê-lo conectado. As áreas de saúde, no entanto, têm pesquisado e alertado acerca dos danos ao desenvolvimento infantil causados pelo uso de telas. O presente estudo procura confrontar a perspectiva do Design da Informação sobre o uso de telas com o conhecimento produzido por áreas da saúde. Enquanto primeiro passo exploratório, este artigo conta com uma pesquisa sistemática rodada com a metodologia TEMAC dentro da área da nutrição. Foram obtidos 408 resultados e 7.470 citações. Nota-se um padrão aparente de correlação entre uso excessivo de telas e maus padrões alimentares entre crianças. É possível notar que há uma preocupação latente da comunidade da saúde relacionada ao consumo de telas por crianças.
AS CONTRIBUIÇÕES DA PSICOMOTRICIDADE PARA O DESENVOLVIMENTO INTEGRAL DAS CRIANÇAS DO PROGRAMA DE ESTIMULAÇÃO PRECOCE: UM RELATO DA APAE DE ARARANGUÁ
Authors: Pereira Taina , Bobsin Andressa da Silva , Oliveira Rosa Maria de
Published: September 2024

A psicomotricidade é uma área do conhecimento que busca realizar intervenções voltadas ao movimento do corpo, favorecendo o desenvolvimento dos aspectos físicos, mentais,
afetivo-emocionais, socioculturais, contribuindo para o processo de aprendizagem da criança.
Na presença de algum atraso global do desenvolvimento, a educação psicomotora é ainda mais
indispensável, pois assegura a estimulação de todos esses aspectos, levando a criança a tomar
consciência de seu próprio corpo, da lateralidade, adquirindo a capacidade para situar-se no
espaço, para dominar o tempo, auxilia na coordenação de seus gestos e possibilita o controle
de suas ações motoras. Deste modo, este trabalho tem como objetivo fazer um relato sobre a
implementação do serviço de psicomotricidade na APAE de Araranguá, refletindo sobre as
contribuições das práticas realizadas para o desenvolvimento integral das crianças atendidas no
Programa de Estimulação Precoce. Para tanto, o relato de experiência, contempla algumas considerações sobre os critérios necessários para a criança frequentar o Programa de Estimulação
Precoce, a organização e estrutura dos atendimentos, os materiais utilizados e o espaço físico
onde acontecem as atividades relativas ao Serviço de psicomotricidade, além de uma reflexão
teórica sobre o tema. Como resultados é possível afirmar que ações realizadas no serviço demandaram um processo de avaliação, que auxiliou tanto na identificação e acompanhamento
das condições específicas de cada educando, bem como para nortear as atividades e práticas a
serem desenvolvidas. Seguindo esse processo, a psicomotricidade exerce um papel fundamental no desenvolvimento integral das crianças que apresentam algum atraso no desenvolvimento
COMPILADO FONOAUDIOLÓGICO
Authors: Farias Samia Monaliza Costa , Massih Cristiane Guerreiro Pereira Abdul , Marinho Christiane de Carvalho , Liberti Kátia Simone Kietzer
Published: September 2024

É com grande satisfação que apresentamos este compilado acadêmico dedicado ao campo da Fonoaudiologia. Ao longo das páginas deste livro, os acadêmicos terão acesso a uma compilação de conhecimentos, reflexões e pesquisas elaboradas por fonoaudiólogos especialistas e estudiosos comprometidos com o avanço do conhecimento nessa área.
A Fonoaudiologia é uma área que abrange uma variedade de disciplinas e abordagens. Neste compilado, buscamos oferecer uma visão abarcante e atualizada sobre diversos aspectos que envolvem a fonoaudiologia, desde questões clínicas e terapêuticas até aspectos interdisciplinares, de relevância para acadêmicos em formação e profissionais da fonoaudiologia.
Cada capítulo reflete o compromisso dos autores em compartilhar suas descobertas, insights e perspectivas com a comunidade acadêmica e profissional, contribuindo assim para o avanço do ensino e para a melhoria dos serviços de saúde. Esperamos que este compilado seja uma fonte valiosa de informação e inspiração para todos aqueles interessados na área da fonoaudiologia e áreas afins. Que as reflexões aqui apresentadas possam estimular novas investigações, debates e ações.
TRANSIÇÃO DEMOGRÁFICA E EPIDEMIOLÓGICA
Authors: Soares Fábio Kawan Monteiro , Silva Felipe Castro Carvalho , Ramos Isaac Prado , Araújo Priscila Xavier de , Tannus Lorena de Oliveira , Sabbá Amanda da Costa Silveira
Published: September 2024

O presente capítulo tem como objetivo explorar a transição demográfica e epidemiológica, abordando suas principais características, fatores determinantes e consequências para a saúde pública.
VIGILÂNCIA EPIDEMIOLÓGICA
Authors: Sirqueira Dháfany Rodrigues , Alves Ayla Joana Regina dos Santos , Tannus Lorena de Oliveira , Caldas Ivete Furtado Ribeiro , Oliveira Ana Costa de , Anjos Fernanda Póvoas dos , Sabbá Amanda da Costa Silveira
Published: September 2024

O principal objetivo da Vigilância Epidemiológica é fornecer orientação técnica e permanente para profissionais da saúde, esses que têm a responsabilidade de decisão, tornando disponíveis informações atualizadas sobre a ocorrência de doenças e agravos, tal como fatores condicionantes, em área geográfica ou população definidas.
EPIDEMIOLOGIA E SAÚDE AMBIENTAL
Authors: Silva Camila Marcela Oliveira da , Silva Dulce Jomayra Pinheiro , Siqueira Gabriela Pompeu , Medeiros Maria de Nazaré da Rocha , Amorim Valéria Caldas , Tannus Lorena de Oliveira , Sabbá Amanda da Costa Silveira
Published: September 2024

A epidemiologia estuda inúmeros ramos da saúde humana, entre eles as doenças causadas pelos fatores ambientais. Desta forma, ela aborda os efeitos e ocorrências de possíveis patógenos, suas relações com os serviços de saúde e Meio Ambiente.
BOLETIM EPIDEMIOLÓGICO
Authors: Pedroza Athos Costa , Nascimento Jessica Silva do , Tannus Lorena de Oliveira , Silvestre Luciana Constantino , Tozetto David José Oliveira , Sabbá Amanda da Costa Silveira
Published: September 2024

Uma importante ferramenta de vigilância é o boletim epidemiológico, utilizado para divulgação de informações técnico-científicas para atualizar, monitorar e investigar doenças sazonais. Nesse instrumento são divulgadas descrições de monitoramento de eventos e doenças com potencial para desencadear emergência de Saúde Pública; análises da situação epidemiológica de doenças e agravos de responsabilidade da SVS; relatos de investigação de surtos e de outros temas de interesse da Vigilância em Saúde para o Brasil.
SAÚDE BUCAL NA INFÂNCIA: ESTRATÉGIAS DE PREVENÇÃO E TRATAMENTO PARA GARANTIR UMA BOA SAÚDE BUCAL EM CRIANÇAS
Authors: Souza Alyce Araujo , Gomes Bernardo Rurik Aparecido , Sousa Daniela Barros Costa de , Alcobaces Érika Araújo , Vacari Maria Fernanda do Carmo , Silva Guilherme Lacerda , Oliveira Théo Souza de , Duarte Victor Gabriel Nascimento
Published: September 2024

A saúde bucal infantil é fundamental para o desenvolvimento e bem-estar das crianças. Este trabalho examina a importância da higiene oral desde os primeiros anos de vida, enfatizando práticas preventivas, hábitos saudáveis e o papel da educação. São abordados temas como a escovação regular, o uso do fio dental e as visitas ao dentista, além dos riscos do consumo excessivo de açúcar e da má alimentação. A influência dos pais e cuidadores e a implementação de programas educativos nas escolas são destacados como essenciais para a promoção de hábitos saudáveis.

Palavras-chaves: Saúde bucal, cárie na infância, higiene oral.
AÇÕES DO ENFERMEIRO NO CUIDAR DA SAÚDE MENTAL: ESTRATÉGIAS PARA O PACIENTE ADULTO
Authors: Mendes Mackilda Eduarda Lobato , Oliveira Clarine De Cássia Ribeiro De , Cantanhede Claudilene Freitas , Nogueira Emanuelle Vieira , Viana Luciana Soares , Torres Márcia Barreto , Arruda Rute Jacaúna , Ferreira Viviane Oliveira , Souza Mariane de Amarantes
Published: September 2024

O cuidado em Saúde Mental deve incluir ferramentas e ações que potencializam o cuidado. Assim, é pertinente a presença de profissionais capacitados em acolher, orientar e assistir os pacientes que se encontram vulneráveis. Este artigo tem como objetivo identificar as ações e estratégias em saúde mental no âmbito da atuação da enfermagem e destacar como estas podem contribuir para uma melhor assistência aos pacientes adultos. Tratou-se de uma revisão integrativa da literatura, cuja pergunta norteadora do estudo foi definida como: Quais as ações e estratégias em saúde mental no âmbito da atuação da enfermagem podem contribuir para uma melhor assistência aos pacientes adultos? As bases de dados utilizadas para a pesquisa foram: SCIELO e LILACS. Os descritores utilizados foram: Saúde Mental e Enfermagem. Foram incluídos artigos científicos publicados em português e inglês, disponíveis na íntegra e de forma gratuita. Contemplou-se estudos publicados entre os anos de 2019 a 2023. Foram incluídas 5 pesquisas, no qual identificaram a importância da estruturação de ações preventivas de agravos à saúde mental de pacientes adultos, bem como na promoção de estratégias de acolhimento e escuta qualificada. Portanto, é pertinente que o enfermeiro elabore estratégias e intervenções, através de estimulações sensoriais, promoção da orientação, envolvimento familiar, garantindo um ambiente confortável, seguro, com promoção do sono e mobilização precoce.

Palavras-chave: Ações de Enfermagem. Enfermagem. Saúde Mental.