bluuebunny/crossref_metadata_2025 huggingface dataset:
Probiotic Lactobacillus and the potential risk of spreading antibiotic resistance: a systematic review
Authors: Shahali Ali , Soltani Rasool , Akbari Vajihe
Published: August 2023

Background and purpose:

Lactobacillus, the most popular probiotic, has recently gained more attention because it is a potential reservoir of antibiotic resistance. This review summarized and discussed the phenotypic-genotypic characteristics of antibiotic resistance.

Experimental approach:

Google Scholar, PubMed, Web of Science, and Scopus were searched up to February 2022. The inclusion criteria were all studies testing antibiotic resistance of probiotic Lactobacillus strains present in human food supplementation and all human/animal model studies in which transferring antibiotic-resistant genes from Lactobacillus strains to another bacterium were investigated.

Findings/Results:

Phenotypic and genotypic characterization of Lactobacillus probiotics showed that the most antibiotic resistance was against protein synthesis inhibitors (fourteen studies, 87.5%) and cell wall synthesis inhibitors (ten studies, 62.5%). Nine of these studies reported the transfer of antibiotic resistance from Lactobacillus probiotic as donor species to pathogenic bacteria and mostly used in vitro methods for resistance gene transfer.

Conclusion and implications:

The transferability of resistance genes such as tet and erm in Lactobacillus increases the risk of spreading antibiotic resistance. Further studies need to be conducted to evaluate the potential spread of antibiotic resistance traits via probiotics, especially in elderly people and newborns.
Bioinformatic analysis of highly consumed phytochemicals as P-gp binders to overcome drug-resistance
Authors: Rajaei Narges , Rahgouy Ghazaleh , Panahi Nasrin , Razzaghi-Asl Nima
Published: August 2023

Background and purpose:

P-glycoprotein (P-gp) is an adenosine triphosphate (ATP)-dependent membrane efflux pump for protecting cells against xenobiotic compounds. Unfortunately, overexpressed P-gp in neoplastic cells prevents cell entry of numerous chemotherapeutic agents leading to multidrug resistance (MDR). MDR cells may be re-sensitized to chemotherapeutic drugs via P-gp inhibition/modulation. Side effects of synthetic P-gp inhibitors encouraged the development of natural products.

Experimental approach:

Molecular docking and density functional theory (DFT) calculations were used as fast and accurate computational methods to explore a structure binding relationship of some dietary phytochemicals inside distinctive P-gp binding sites (modulatory/inhibitory). For this purpose, top-scored docked conformations were subjected to per-residue energy decomposition analysis in the B3LYP level of theory with a 6-31g (d, p) basis set by Gaussian98 package.

Findings/Results:

Consecutive application of computational techniques revealed binding modes/affinities of nutritive phytochemicals within dominant binding sites of P-gp. Blind docking scores for best-ranked compounds were superior to verapamil and rhodamine-123. Pairwise amino acid decomposition of superior docked conformations revealed Tyr303 as an important P-gp binding residue. DFT-based induced polarization analysis revealed major electrostatic fluctuations at the atomistic level and confirmed larger effects for amino acids with energy-favored binding interactions. Conformational analysis exhibited that auraptene and 7,4′,7″,4‴-tetra-O-methylamentoflavone might not necessarily interact to P-gp binding sites through minimum energy conformations.

Conclusion and implications:

Although there are still many hurdles to overcome, obtained results may propose a few nutritive phytochemicals as potential P-gp binding agents. Moreover; top-scored derivatives may have the chance to exhibit tumor chemo-sensitizing effects.
Honokiol inhibits the growth of hormone-resistant breast cancer cells: its promising effect in combination with metformin
Authors: Mikhaevich Ekaterina I. , Sorokin Danila V. , Scherbakov Alexander M.
Published: August 2023

Background and purpose:

Primary and metastatic breast cancers still represent an unmet clinical need for improved chemotherapy and hormone therapy. Considerable attention has been paid to natural anticancer compounds, especially lignans. The study aimed to evaluate the activity of several lignans against breast cancer cells and assess the effect of leading lignans on signaling pathways in combination with metformin.

Experimental approach:

Human breast cancer cell lines MCF7 (hormone-dependent), MDA-MB-231, and SKBR3 (hormone-independent) were used. A hormone-resistant MCF7/hydroxytamoxifen (HT) subline was obtained by long-term cultivation of the MCF7 line with hydroxytamoxifen. Antiproliferative activity was assessed by the MTT test; the expression of signaling pathway proteins was evaluated by immunoblotting analysis.

Findings/Results:

We evaluated the antiproliferative activity of lignans in breast cancer cells with different levels of hormone dependence and determined the relevant IC50 values. Honokiol was chosen as the leading compound, and its IC50 ranged from 12 to 20 μM, whereas for other tested lignans, the IC50 exceeded 50 μM. The accumulation of cleaved PARP and a decrease in the expression of Bcl-2 and ERα in MCF7/HT were induced following the combination of honokiol with metformin.

Conclusions and implications:

Honokiol demonstrated significant antiproliferative activity against both hormone-dependent breast cancer cells and lines with primary and acquired hormone resistance. The combination of honokiol with metformin is considered an effective approach to induce death in hormone-resistant cells. Honokiol is of interest as a natural compound with antiproliferative activity against breast cancers, including resistant tumors.
Obesity as a Trigger for Autoimmune Rheumatic Diseases
Authors: Hemanth Kumar H. R. , Kalyan Meenakshi , Vedula Aditya , Kolli Chaitra , Saba Sania , Dharma Shashank
Published: August 2023

The chronic low-grade inflammation in obesity and multiple pleiotropic effects of adipokines on the immune system has been implicated in the pathogenesis of various rheumatic autoimmune and inflammatory conditions. Obesity is a low-grade systemic inflammatory condition with elevated levels of inflammatory markers such as leptin, C-reactive protein, tumor necrosis factor-α, and interleukin-6. Dysregulation of the cytokines and adipokines is a feature of metabolic syndrome, suggesting a complex relationship between autoimmunity, obesity, and atherosclerosis. We discuss the effects of obesity and its association with newly diagnosed immune-mediated disorders such as Sjogren's syndrome, systemic lupus erythematosus, rheumatoid arthritis, and antiphospholipid antibody syndrome in a case series of eight patients.
Managing patients with vitiligo by narrowband–ultraviolet-B and systemic vitamin D
Authors: Alsabbagh Manal M. , Kassim Azad K.
Published: August 2023

Background

The role of vitamin D in autoimmune disorders in general and in vitiligo in specific has drawn the attention of many authors recently. Topical vitamin D is known to help in restoring pigmentation in vitiligo. The effect of vitamin D deficiency in vitiligo is still not fully understood.

Aim

To examine the effect of correcting vitamin D deficiency on the clinical improvement of vitiligo.

Setting and design

A randomized clinical trial where patients attending the Dermatology Clinic and diagnosed with vitiligo were invited to participate.

Patients and methods

In all, 26 patients with vitiligo and vitamin D deficiency were recruited, and by simple randomization, they were assigned into one of the 12-week therapeutic groups: a combined therapy of narrowband–ultraviolet-B (NB–UVB) and oral vitamin D, and a monotherapy of oral vitamin D or a monotherapy of NB–UVB. Serum level of vitamin D was measured at three occasions; before and after treatment, and at onset of repigmentation. Statistical analysis: SPSS was used for statistical analysis; A P value of less than 0.05 was considered as statistically significant.

Results

Patients on a combined therapy of NB–UVB and oral vitamin D required the shortest time for repigmentation (2.4 weeks) compared with monotherapy of vitamin D (4.8 weeks) or phototherapy (6.4 weeks) (P<0.05). However, the relationship between serum vitamin D level and onset of repigmentation was insignificant.

Conclusions

Replacement of vitamin D might positively influence the course of vitiligo management when combined with phototherapy. Further studies are required to confirm and identify the exact role vitamin D.
A clinical and histopathological study comparing the efficacy and safety of carboxytherapy, platelet-rich plasma, and fractional carbon dioxide laser in the treatment of striae distensae
Authors: Eldawla Reham Ezz , El-Deen Yassin Fatma El-Zahraa Salah , Al-Shandawely Aya A. , Aboeldahab Soha
Published: August 2023

Background

Striae distensae (SD) are linear scars that develop in the areas of dermal damage owing to overstretching of the skin. No gold standard line of treatment has been determined.

Objectives

To compare the efficacy and safety of carboxytherapy, platelet-rich plasma (PRP), and fractional carbon dioxide (CO2) laser in the treatment of SD clinically and histopathologically.

Patients and methods

The study included 37 female patients with SD, aged 18–50 years. Complete history taking and general and dermatological examinations were performed. The study population was randomly divided into three groups: group A was treated with carboxytherapy, group B was treated with PRP, and group C was treated with fractional CO2 laser. The groups were treated each for six sessions with 3-week intervals and followed up after a month from the last treatment session. The session showing the beginning of improvement and the overall improvement were recorded in each group. Adverse effects, as well as the satisfaction of patient and dermatologist, were also evaluated and graded. The pretreatment and posttreatment histopathological changes in each group were evaluated and recorded according to a modified scoring system. Masson’s Trichrome staining was performed to evaluate the collagen content.

Results

In the present study, the highest ratio of the overall improvement was observed in group C followed by group B and group A. Histopathological improvement was observed in the three groups with different mechanisms according to the applied treatment. Fractional CO2 laser showed more histopathological improvement than the other treatment modalities.

Conclusions

The present study concluded that carboxytherapy, PRP, and fractional CO2 laser were clinically and histopathologically effective and safe treatment options for mild to severe SD. Fractional CO2 laser was more effective especially in cases of moderate to severe striae albae. Although it is an expensive treatment method, it resulted in a higher satisfaction rate between the patient and dermatologist with a good safety profile and tolerability.
Skin and soft tissue disorders in patients with substance-use disorders
Authors: Tabari Sudabeh T. , Motahari Maryam , Ranaee Mohammad , Gholinia Hemmat , Moudi Sussan
Published: August 2023

Introduction

Skin and soft tissue disorders are common problems in patients with substance use. This research was conducted to assess the different types of skin and soft tissue problems in patients with substance use disorders.

Patients and methods

This observational research was conducted as a cross-sectional study among patients with substance use disorders, who were referred to governmental methadone maintenance treatment centers affiliated to Babol University of Medical Sciences, North of Iran. The patients were assessed by the research dermatologist and a psychiatrist. During a complete physical examination of the skin, hair, and nails and, if necessary, a biopsy of suspected lesions, various skin and soft tissue disorders were identified and classified.

Results

In total, 197 patients (188 men and nine women) with a mean age of 43.74±12.94 years were included in the research. Following complete examination, 10 (5.1%) patients with skin and soft tissue disorders were identified, of which three (30%) had pruritic eczema, two (20%) had psoriasis, one (10%) patient vitiligo, one (10%) had eczema with vasculitis, one (10%) had scarring and seborrheic keratosis, and two (20%) patients had inflammatory lesions. No significant association was found between skin disorders and age (P=0.14), sex (P=0.99), marital status (P=0.32), level of education (P=0.81), occupation (P=0.70), and living condition (P=0.23). Patients with heroin use had a significant difference with other substance users on the occurrence of skin disorders (P<0.001).

Conclusions

Dermatologic disorders should be considered in individuals with substance use disorders. Periodic skin examination of these patients is recommended.
Paederus Dermatitis’ Outbreak in Residential Hostels – A Retrospective Clinical Study
Authors: Chintagunta Sudha Rani , Jaju Priyanka , Kotagiri Sagar
Published: August 2023

Introduction:

Paederus dermatitis is an acute irritant dermatitis caused by accidental crushing of an insect belonging to the genus Paederus, releasing the vesicant pederin. It is commonly seen in the rainy season, especially in tropical regions.

Methods:

The aim of this study is to analyze the epidemiological and clinical findings of paederus dermatitis and factors associated with this condition in patients attending the dermatology, venereology and leprosy (DVL) department at a tertiary care hospital. This is a 3-year retrospective study from November 2016 to December 2019. This study was undertaken as a large number of cases with similar complaints attended D.V.L outpatient department during the same period (November–January) in 3 consecutive years. A total of 120 girls clinically diagnosed with paederus dermatitis residing in residential girls’ hostels were included in the study. All the cases were evaluated using a standard pro forma which included a detailed history and clinical examination. All the patients were treated appropriately and control measures were advised to prevent further attacks. Patients were followed up until the lesions healed for 2 weeks.

Results:

Age of the children ranged from 10 to 16 years. The mean age of patients was 13.4 years. The majority of the cases were reported in November (57) and December (42) for 3 consecutive years and the remaining cases were observed randomly during the study period. Most of the patients presented within 48–96 h of lesion onset. The chief complaints were redness of the skin with itching and burning. The most common presentation was widespread erythema, edema, erosions, and desquamation involving larger areas, not localized which is uncommon with paederus dermatitis. Facial involvement is significant and observed in 99 (82.5%) cases. In addition to the face, other sites affected were the neck in 82 (68.3%), forearms in 41 (34.16%), and upper trunk in 30 (25%) patients. Constitutional symptoms although mild were reported in 3% of patients.

Conclusion:

An atypical variant of paederus dermatitis was observed in the majority of the cases with diffuse erythematous and desquamative lesions predominantly involving the face and neck. A careful history and awareness about varied clinical features will help in early diagnosis and to undertake preventive measures.
Clinicoepidemiological Profile of Childhood Leprosy in a Tertiary Care Hospital of North Karnataka
Authors: Parsam Suman Babu , Kadi Ramesh
Published: August 2023

Background:

Childhood leprosy is an indicator of ongoing transmission of the disease. The prevalence rate of pediatric leprosy is considered an important epidemiological index for determining the level of transmission of the disease. Our aim was to estimate the proportion of leprosy cases among children aged 0–14 years in our tertiary care hospital.

Methods:

A retrospective study was carried out for a period of 4 years from January 2017 to December 2020. Secondary data were collected from leprosy records pertaining to childhood leprosy (aged between 0 and 14 years). Only new cases presented during the period were included. Details of the patients such as age, sex, family history, number and site of lesions, nerve involvement, reactions, and deformities were noted. Slit-skin smear and biopsy findings were tabulated and descriptive analysis was done.

Results:

Fifty-five cases (9.54%) of childhood leprosy were diagnosed. Majority of the cases were in the age group of 10–14 years. The most common leprosy type was borderline tuberculoid found in 42 patients (76.36%). Forty-nine patients (89.09%) had paucibacillary (PB) and 6 (10.91%) had a multibacillary type. The most common presenting symptom was patch (61.8%). Eleven patients had a family history. Clinicopathological correlation was observed in 50 (90%) patients. Lepra reactions were seen in six (10.9%) patients and two deformities in three patients.

Conclusion:

The proportion of pediatric leprosy cases was 11.61% in 2017 and decreased to 6.45% in 2020. PB type is the most common type. To achieve zero childhood leprosy cases, thorough follow-up and contact tracing of adult leprosy patients, early diagnosis of childhood leprosy to prevent disabilities is the need of the hour.
CLOVES Syndrome: An Unusual Presentation of a Rare Entity
Authors: Hegde Pallavi , Choubey Vikrant , Sahoo Bijaylaxmi
Published: August 2023

CLOVES syndrome is a rare disorder that falls under the spectrum of clinically and etiologically heterogenous “vascular malformation with limb overgrowth syndromes.” An 8-year-old male child presented with overgrowth of limbs, multiple vascular malformations, epidermal nevus, skeletal anomalies, and undescended testis, based on which a diagnosis of CLOVES syndrome was made. This publication serves to discuss the classical features of this rare syndrome and to report undescended testis, which is an unusual feature. Identifying this variable constellation of features is essential to differentiate the condition from other similar disorders for purposes of academics, research, and patient care.
Pharmacokinetic Assessment of Pyrazinamide and Pyrazinoic Acid in Carbon tetrachloride-induced Liver Injury Model in Wistar Rats
Authors: Sharma Swati , Sharma Vishal , Taneja Sunil , Bhatia Alka , Anand Aishwarya , Banerjee Dibyajyoti , Patil Amol N.
Published: August 2023

ABSTRACT

Background:

We investigated the pharmacokinetic behavior of pyrazinamide (PZA) and pyrazinoic acid (PA) in the presence of carbon-tetrachloride (CCl4) plus antitubercular treatment (ATT) drug-induced liver injury (DILI) in rats.

Methods:

Thirty rats utilized in the experiment were separated equally into five groups. Each rat was injected with 0.5 ml/kg CCl4 intra-peritoneal injection on day zero. Group, I rats did receive only CCl4 (single i.p. injection, 0.5 ml/Kg in olive oil in a 1:1 ratio). Groups II, III, IV, and V did receive daily oral PZA, PZA plus isoniazid (INH), rifampicin (RMP) plus pyrazinamide (PZA), and three drugs together, respectively, for 21-days. Pharmacokinetic sampling was performed at 0, 0.5,1,3,6,12 and 24 hours post-dosing on day-20. Liver function test (LFT) was assessed at days 0,1,7, and 21 days after CCl4 and ATT administration, and rats were sacrificed on the last experiment day.

Results:

ATT treatment maintained the liver function changes initiated by CCl4 administration. An evidential LFT rise was observed in groups administered with pyrazinamide. Co-administration of Isoniazid caused a 2.02 and 1.78 times increase in Area-under-the-curve (AUC) values of PZA and PA, respectively (p < 0.05). Histological and oxidative-stress changes supported the biochemical and pharmacokinetic observations.

Conclusion:

The enzyme inhibitory capacity of isoniazid is well-preservd in CCl4-induced liver injury.
Knowledge, Attitude, and the Practice of Community Pharmacists to Dispense Opioid-Related and Opioid-Containing Medication in Eastern Province, Saudi Arabia
Authors: Ali Mohammad D. , Al Mubarak Fatimah E. , Ghosn Sherihan A. , Ahmad Ayaz , Alhussini Sara H. , Almozien Sara F. , Alowaywi Ghadeer A. , Albeladi Banin H.
Published: August 2023

ABSTRACT

Objectives:

This study was done to evaluate the knowledge of community pharmacists—working in Saudi Arabia—regarding over-the-counter opioid-related and opioid-containing medications.

Materials and Methods:

A quantitative cross-sectional study was conducted using an online questionnaire that was distributed through social media and taken to the community pharmacists in person. A total of 101 responders were reached in a period of around 3 weeks.

Results:

Most of the pharmacists working in community pharmacies in Saudi Arabia are non-Saudi (85.15%), males (88.12%), and the majority are holders of bachelor’s degrees (85.15%). More than half of the participants spend a considerably sufficient time with the patient 6–10 minutes (60.4%). The availability of a private counseling room in community pharmacies is significantly low (21.78%). Only (69.41%) of participants always counsel the patient before dispensing opioid-related medications. Most of the participants (84.76%) believe that all over-the-counter opioid-related and opioid-containing medications should be restricted to avoid drug abuse.

Conclusion:

A little neglect from pharmacists’ side regarding dispensing such medications was observed; thus, there is a significant need to raise their awareness regarding over-the-counter opioid abuse.
A Novel Technique of Vascularised Fibular Epiphyseal Transfer Combined with Cryosterilized Autograft and 3D Printing in a 2-year-Old Child with Ewing's Sarcoma
Authors: Beltrami Giovanni , Chinder Pramod S. , Sreeraj R. , Hindiskere Suraj , Raghavendra Sohan Pothaganahalli , Doddarangappa Srinath
Published: August 2023

Vascularized fibular epiphyseal transfer (VFET) though technically challenging, is a technique which can be used in skeletally immature patients to preserve the limb length in tumors near physis. As limb salvage at a young age adds to the complexity of the procedure since the growth potential of the limb has to be considered to restore the optimal function of the salvaged limb. This case report documents the treatment of an Ewing's Sarcoma of the left proximal tibia in a 2-year-old boy, following VFET modified with free freezing liquid nitrogen and three-dimensional printing. We succeeded in improving the patient's oncological and functional outcome because our patient was mobilized early and no postoperative complications occurred. This technique can thus be considered for the biological reconstruction of very young children as it has the least influence on limb lengths and growth potential.
Evaluation of Tumor-Infiltrating Lymphocytes as a Prognostic Indicator of Head-and-Neck Squamous Cell Carcinomas
Authors: Reddy N. Apoorva , Joshna B. M. , George Abhijith , Indu V. P. , Thakur Shalini , Subash Anand , Kudpaje Akshay , Rao Vishal US
Published: August 2023

Introduction:

The incidence of Head-and-Neck Squamous Cell Carcinomas (HNSCC) is on the rise in our country and worldwide, with a worsening prognosis. The abundance of tumor-infiltrating lymphocytes (TILs) is evolving to be a novel prognostic indicator in assessing treatment response of HNSCC. TILs mainly comprise T lymphocytes, which migrate from blood into the tumor as part of the body's immune response. In this context, targeting the tumor microenvironment with the help of immunotherapy may present a potential approach for better cure of head-and-neck cancers. In the present study, we evaluated the potential TILs parameters which can be used in clinical practice to predict treatment outcomes in HNSCC.

Materials and Methods:

This is a prospective observational study of 41 patients conducted at a tertiary cancer center between September 2019 and September 2020. All patients with biopsy proven, primary/recurrent HNSCC, without distant metastasis, and complete clinicopathological data were included in the study. Patients with a nonsquamous cell carcinoma, patients who underwent upfront chemotherapy or chemoradiotherapy were excluded from the study. Patients who had follow-up of <1 year or lost to follow-up were excluded from the study. Parameters analyzed include mean age; percentage of cluster of differentiation 3 (CD3) cells; CD4, CD8, and FOXP3cell counts; distribution of CD57 and CD3/FOXP3 ratio.

Results:

A total number of 19 patients were grouped under the nonrecurrence TILs and 22 patients under recurrent TILs category. Majority of the patients (90.2%) had oral cavity squamous cell carcinoma. 68.42% of nonrecurrent cases and 36.36% of recurrent cases were found to be harboring Hot tumors. Using odds ratio, it was noted that the odds of having Hot tumor is 3.79 times (95% confidence interval: [1.03,13.91]) higher in nonrecurrent TILs than in recurrent TILs group. CD3 cell count was higher in nonrecurrent cases (54.74 ± 18.37) than in recurrent cases (42.73 ± 16.09) with P = 0.0157. Using two tailed t-test, it was noted that the mean of CD4, CD8, and FOXP3 is not significantly different between nonrecurrent and recurrent tumor TILs groups.

Conclusion:

To summarize, we have shown that the CD3/FOXP3 cell ratio, rather than the individual proportion of TILs, is a significant prognostic indicator in HNSCC. It's also been shown that people with Cold tumors have a higher risk of recurrence than those with Hot tumors. Our findings confirm the importance of host immunity in prognosis and suggest that the degree of immune cell infiltration in the tumor microenvironment is a major independent prognostic factor that merits further investigation as a potentially valuable biomarker in HNSCC patients.
Febrile neutropenia
Authors: Jadhav Sachin Suresh , Kumar Jyothi Goutham , Tripathi Priyank , Matani Anjali , Ganesan Shobha K , Vishnupriya  , Panchal Amey C , H.Kaswala Chintan Kumar , Nishit  , Koramati Samuel L , Ajaikumar BS
Published: August 2023

We present a case of febrile neutropenia in a patient with acute myeloid leukemia caused by an uncommon bacterial species. The patient was treated with antibiotics for 14 days before being discharged. Pantoea agglomerans is a plant soil and water-dwelling agricultural organism. It is both a commensal and pathogen of animals and humans, according to earlier research. In conclusion, p. agglomerans should be considered a bacterial threat in cancer patients who are undergoing highly myelotoxic chemotherapy.
Short-term Impact of Hormone Replacement Therapy on Risk of Breast Cancer in BRCA Mutation Carriers: A Nationwide Study in South Korea
Authors: Kim Hye Yeon , Park Jisoo , Moon Seok Joo , Jeong Sohyeon , Hong Jin Hwa , Lee Jae Kwan , Cho Geum Joon , Cho Hyun-Woong
Published: August 2023

Purpose BRCA1/2 mutations are well-known risk factors for breast and ovarian cancers in women. Risk-reducing salpingo-oophorectomy (RRSO) is the standard treatment for preventing ovarian cancer with BRCA mutations. Postmenopausal syndrome (symptoms after RRSO can be alleviated by hormone replacement therapy (HRT); however, the use of HRT in carriers of BRCA mutations has been controversial because of the concern that HRT increases the risk of breast cancer. This study aimed to evaluate the effects of HRT in BRCA mutation carriers who underwent RRSO.Materials and Methods A total of 151 carriers, who underwent RRSO between 2013 and 2020 after the diagnosis of BRCA1 or BRCA2 mutations were selected and followed up for a median of 3.03 years. Patients were divided into two groups: those who received HRT after RRSO (n=33) and those who did not (n=118). We compared the incidence of breast cancer over time between these two groups.Results There was no significant difference in the incidence of breast cancer between women who received HRT and those who did not (p=0.229). Multivariate logistic regression analysis, adjusted for age and parity revealed no significant difference in the risk of breast cancer between these two groups (hazard ratio, 0.312; 95% confidence interval, 0.039 to 2.480; p=0.278).Conclusion In this study, we found no relationship between post-RRSO HRT and breast cancer in the population with BRCA mutations. Therefore, healthcare providers may consider the alleviation of symptoms of postmenopausal syndrome through HRT in patients who underwent RRSO.
A Borel–Weil theorem for the quantum Grassmannians
Authors: Carotenuto Alessandro , Mrozinski Colin , Ó Buachalla Réamonn
Published: August 2023

We establish a noncommutative generalisation of the Borel–Weil theorem for the celebrated
Heckenberger–Kolb calculi of the quantum Grassmannians. The result is formulated in the
framework of quantum principal bundles and noncommutative complex structures, and generalises
previous work of a number of authors on quantum projective space. As a direct consequence we get
a novel noncommutative differential geometric presentation of the twisted Grassmannian coordinate
ring studied in noncommutative projective geometry. A number of applications to the noncommutative
Kähler geometry of the quantum Grassmannians are also given.
PENGARUH MODEL COOPERATIVE LEARNING TIPE STAD TERHADAP HASIL PEMBELAJARAN KIHON KATA PADA MATA KULIAH KARATE
Authors: Manullang Jujur Gunawan , Handayani Widya , Hermansah Bambang
Published: August 2023

Untuk meningkatkan penguasaan keterampilan kihon kata dalam mata kuliah karate, diperlukan suatu model pembelajaran yang harus diterapkan oleh seorang dosen. Salah satu model yang dapat digunakan adalah model pembelajaran kooperatif tipe STAD. STAD merupakan tipe kooperatif yang menekankan pada aktivitas dan interaksi antar siswa untuk saling memotivasi dan saling membantu dalam penguasaan materi. Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran kooperatif tipe STAD terhadap hasil belajar mata kuliah karate. Metode yang digunakan dalam penelitian ini adalah metode eksperimen. Populasi dalam penelitian ini adalah mahasiswa Pendidikan Jasmani Universitas PGRI Palembang yang mengikuti perkuliahan karate. Sampel dalam penelitian ini diambil secara acak dengan menggunakan teknik random sampling sebanyak 38 siswa yang dibagi menjadi dua kelompok. Analisis statistik yang digunakan adalah analisis uji-t dengan kesamaan dua rata-rata satu pihak. Hasil pengujian menunjukkan bahwa thitung lebih besar dari ttabel. Kriteria Dalam hal ini t hitung berada pada daerah penolakan Ho, maka Ho ditolak dan H1 diterima yang artinya terdapat pengaruh yang signifikan model pembelajaran kooperatif tipe STAD terhadap hasil belajar kata kihon.
PENGEMBANGAN MODEL PEMBELAJARAN SENAM LANTAI BERBASIS MULTIMEDIA
Authors: Suhairi Muhammad , Effendi Awang Roni , Rajidin Rajidin
Published: August 2023

This study aims to produce interactive multimedia-based floor gymnastics learning media for Jamani Education Study Program students at IKIP PGRI Pontianak in the floor gymnastics course. This study uses the Research and Development (R&D) method with the ADDIE development model (Analysis, Design, Develop, Implement, and Evaluate). Determination of the subject in this study was done with a purposive sample. Informants from the development research carried out consisted of 2 experts, namely; material experts and media experts, small group trials of physical education study students with a total of 20 students as subjects, and large group trials of 40 physical education study students who took floor gymnastics courses. Research data obtained from; product validation design, giving small-scale test questionnaires and large-scale tests. The results showed that the interactive multimedia learning media for floor exercise can be used by teachers and students easily to understand the learning material for floor gymnastics with a very good response.AbstrakPenelitian ini bertujuan untuk menghasilkan media pebelajaran senam lantai berbasis multimedia interaktif untuk mahasiswa Prodi Pendidikan Jamani di IKIP PGRI Pontianak pada mata kuliah senam lantai. Penelitian ini menggunakan metode Research and Development (R&D) dengan model pengembangan ADDIE (Analysis, Design, Develop, Implement, dan Evaluate). Penentuan subjek dalam penelitian ini dilakukan dengan puposive sample. Informan dari penelitian pengembangan yang dilakukan terdiri dari 2 ahli yaitu; ahli materi dan ahli media, uji coba kelompok kecil dari mahasiswa prodi pendidikan jasmani dengan jumlah sabjek 20 mahasiswa, dan uji coba kelompok besar berjumlah 40 mahasiswa prodi pendidikan jasmani yang mengikuti mata kuliah senam lantai. Data hasil penelitian diperoleh dari; desain validasi produk, pemberian angket uji skala kecil dan uji skala besar. Hasil penelitian menunjukkan bahwa media pembelajaran multimedia interaktif senam lantai dapat digunakan oleh pengajar dan mahasiswa secara mudah untuk memahami materi pembelajaran senam lantai dengan respon sangat baik.
Crescimento inicial de Moringa oleifera em substrato arenoso com adição de vermicomposto em duas luminosidades
Authors: Pina José Carlos , Morbeck de Oliveira Ademir Kleber , Matias Rosemary
Published: August 2023

Objetivo: avaliar a formação inicial de mudas de Moringa oleifera durante 150 dias em substrato arenoso com adição de vermicomposto, em duas luminosidades. Método: experimento conduzido em delineamento experimental em blocos inteiramente casualizados, com quatro tratamentos: T1) neossolo quartzarênico 60% + 40% vermicomposto; T2) neossolo quartzarênico 80% + 20% vermicomposto; e, T3) 100% neossolo quartzarênico, sob duas intensidades luminosas (pleno sol ou 70% de radiação solar). As coletas foram realizadas aos 30, 60, 75, 90 e 105 dias após o transplantio e determinada a altura, massa seca da parte aérea, massa seca da raiz, massa seca total, diâmetro do coleto e Índice de Qualidade de Dickson (IQD). Os dados foram visualizados através de curva de regressão e submetidos a análise de variância (teste de Tukey a 5%). Resultados: o substrato com maior concentração de matéria orgânica é o mais adequado para a produção de mudas e a espécie possui plasticidade de crescimento, em relação a luminosidade. Conclusões: o IQD demonstrou que plantas mantidas em maior luminosidade e quantidade de matéria orgânica são mais robustas e o tratamento T1 foi o mais eficaz para a produção de mudas de qualidade.
PHILOSOPHY OF SCIENCE AS THE HISTORICAL BASIS OF THE DEVELOPMENT OF SCIENCE AND KNOWLEDGE
Authors: Lubis Muya Syaroh Iwanda , Fitri Anisa
Published: August 2023

ABSTRACTPhilosophy is an extensive science, meaning it is closely related to our daily lives, and philosophy is the driving force of our daily lives as individual human beings and as collective human beings in the form of a society or nation. Philosophy of science is a philosophical reflection on the nature of science which will not recognize a stopping point towards achieving the goal, namely truth and reality. Understanding the philosophy of science means understanding the intricacies of science so that its most essential aspects and foundations also understand the perspective of science, the possibility of its development, and its interweaving between one branch of science and another. The research approach that researchers use in writing this scientific work is a type of library research. Philosophy is a science that seriously studies the true nature of everything. Science is a method of thinking objectively in describing and giving meaning to the natural and moral world to organize and systematize. Knowledge indicators are: It is accumulative, and its truth is not absolute but objective. There are six phases of scientific development: The Pre-Ancient Greece Phase, the Ancient Greek Phase, the Medieval Age Phase, the Renaissance Age phase, the Modern Age phase, and finally, the Contemporary Age phase. Keywords: Philosophy, Historical, Development, Science, Knowledge
SOURCE OF KNOWLEDGE THROUGH AXIOLOGY PERSPECTIVE
Authors: Nurhayati Nurhayati , Nasution Ibrahim Haidar , Siregar Rafiqah Yusna
Published: August 2023

ABSTRACTThe research aims to discuss the axiological values and sources of knowledge for humans. This research uses the Semut Sumut non-formal education organization as a case study. This article employs a qualitative interpretive approach by conducting library research, specifically by looking at reading materials related to the studies presented and using document analyses of earlier research findings associated with the philosophy of science. Books rading, scientific journals on Google Scholar, and digital libraries were combed through to acquire the data. Results of this study show that axiological values as a source of knowledge can be reflected in social movements by providing non-formal education platforms for children who have dropped out of school or even have no opportunity at all to go to school. The axiological value of social movements contains elements of being functional, robust, valid or strong which means the quality of something that makes it liked, appreciated and appreciated by other parties. In addition, two supporting elements in non-formal learning materials further strengthen the axiological perspective as a source of knowledge, namely ethics and aesthetics. Keywords: Axiology, Knowledge, Semut Sumut.
THE EFFECT OF ORGANIZATIONAL CULTURE AND JOB ENVIRONMENT ON EMPLOYEE IN PT. ASTRA INTERNATIONAL TBK. AUTO 2000 BRANCH OF AMPLAS MEDAN
Authors: Prayoga Diki , Firah Al
Published: August 2023

ABSTRACT This study aims to determine the effect of organizational culture and work environment on employee performance. PT. Astra International Tbk. Auto 2000 is a Toyota car dealer. The population of this study is 61 employees with a sample according to the slovin formula of 30 employees. The data used is quantitative data derived from primary sources. The data collection technique uses a Likert scale with a regressive line analysis method to provide information to respondents (questionnaire). Based on the statistical results obtained tcount 10.886 > ttable 1.697 it can be concluded that there is a positive influence between organizational variables and work environment variables on employee performance at PT. Astra International Tbk Auto 2000 Sandpaper Branch. Based on the results of the coefficient of determination, the R-Square in the regression is 0.911 (91.1%). In this case, the most significant benefit provided by the organization and the workplace is 91.1%, with the remaining 8.9% coming from other variables that were not considered in the study. PT. Astra Internasional Tbk Auto 2000 Amplas Branch must increase and expand the number of courses aligned with job specifications in order to improve organizational health and workforce productivity. Keywords: Organizational Culture, job Environment, Employee Performance
Incorporating Natural Infrastructure in Bogotá’s Water System
Authors: Izquierdo-Tort Santiago , Restrepo-Zambrano Diego , Ozment Suzanne , Acero Natalia , Bulbena Janer Laura , Camacho Juana , Villegas Ortiz Laura , Arjona Fabio , Bejarano Patricia , Mora Mario , Garcia Margoth
Published: August 2023

This report shows how targeted investments in natural infrastructure in the upper basin of the Bogotá River can generate significant cost savings for Bogotá’s water utility. These savings can lead to improved water security for the city through more diverse water sources and reduced pressure for reservoir expansion.
Integrando Infraestructura Natural al Sistema de Abastecimiento de Agua de Bogotá
Authors: Izquierdo-Tort Santiago , Restrepo-Zambrano Diego , Ozment Suzanne , Acero Natalia , Bulbena Janer Laura , Camacho Juana , Villegas Ortiz Laura , Arjona Fabio , Bejarano Patricia , Mora Mario , Garcia Margoth
Published: August 2023

This report shows how targeted investments in natural infrastructure in the upper basin of the Bogotá River can generate significant cost savings for Bogotá’s water utility. These savings can lead to improved water security for the city through more diverse water sources and reduced pressure for reservoir expansion.
Pendidikan Tauhid dalam Kegiatan Tapak Suci Putera Muhammadiyah
Authors: Huwaida Hasna’
Published: August 2023

Islam sebagai agama yang membawa pengertian tauhid dalam ajarannya, tak ayal haruslah menjadi jalan hidup atau way of life bagi setiap pengikutnya. Islam merupakan cara pandang setiap muslim terhadap dunia dan kehidupan yang menyertainya. Hal ini menjadi wajar sebab agama Islam telah memberikan penjelasan yang amat rinci di segala bidang kehidupan. Tak hanya masalah ibadah saja, tetapi termasuk di dalamnya masalah politik, sosial dan budaya. Karenanya, kehidupan seorang muslim tidak akan mungkin lepas dari nafas Islam utamanya dari nilai tauhid. Tapak Suci Putera Muhammadiyah merupakan salah satu wadah pengkaderan Muhammadiyah bagi generasi muda. Sebagai wadah bagi anak muda tersebut, tentu ada upaya-upaya yang dilakukan dalam pemenuhan misi penanaman nilai-nilai tauhid dalam setiap kegiatannya. Salah satu padepokan yang aktif bagi kegiatan tapak suci adalah Padepokan Bina Menggala Tapak Suci Pimda 04 Jember. Penelitian ini bertujuan mengupas berbagai macam kegiatan yang mengandung pendidikan tauhid bagi anggota muda Tapak Suci di Padepokan Bina Menggala Tapak Suci Pimda 04 Jember. Serta menjelaskan tentang metode pelaksaan pendidikan tauhid dalam Tapak Suci yang digunakan. Jenis penelitian yang telah lakukan ini adalah field research, atau studi lapangan dengan cara peneliti terjun secara langsung ke tempat penelitian. Adapun metode penelitian yang kami gunakan adalah metode deskriptif, sedangkan pendekatannya adalah pendekatan kualitatif. Hasil dari penelitian ini menggambarkan beberapa kegiatan yang dilakukan Tapak Suci untuk menanamkan nilai tauhid, serta metode-metode pendidikan tauhid yang digunakan di setiap kegiatan tersebut. Hasil ini menunjukkan kepedulian Tapak Suci sebagai ortom Muhammadiyah atas pentingnya penanaman pendidikan tauhid bagi seluruh anggotanya
Pengajaran Firman Secara Sehat menurut 1 Timotius 1:3-11 dan Implementasinya bagi Pengajar GKI “Galet” Niufmuti Kupang NTT
Authors: Rahardjo Victor Immanuel , Santoso Dwi Setio Budiono , Tana Yandri
Published: August 2023

This research exposes Paul's letter to his spiritual children in 1 Timothy 1:3-11. The method used is field qualitative. There is advice that is relevant for every teacher of God's word at GKI "Galet" Niufmuti Kupang NTT. This study shows if the problem in the context of the Philippians is significant to the problems that occur in the church today. The importance of teaching healthy teachings is still being discussed today. By exposing this passage, we hoped that an awareness will be formed to be able to prepare higher quality teaching for the spiritual life of the congregation. In the sense that following the teachings of the apostles and their successors properly. In addition, even though evangelical preachers work in other professions, as God's servants it is important to prioritize activities that support the spiritual growth of the congregation. This is to avoid the inclusion of unhealthy teachings in the congregation which can be fatal. Penelitian ini mengeksposisi surat Paulus kepada anak rohaninya dalam 1 Timotius 1:3-11. Metode yang digunakan adalah kualitatif lapangan.  Terdapat nasehat yang relevan bagi setiap pengajar firman Tuhan di GKI “Galet” Niufmuti Kupang NTT. Kajian ini menunjukkan jika masalah dalam konteks di jemaat Filipi signifikan dengan masalah yang terjadi di jemaat zaman sekarang. Pentingnya mengajar ajaran sehat masih menjadi diskusi sampai saat ini. Dengan menelaah ulang perikop ini diharapkan akan terbentuk kesadaran untuk dapat mempersiapkan pengajaran lebih bermutu demi kehidupan spiritual jemaatnya. Dalam arti bahwa mengikuti ajaran rasuli dan penerusnya dengan baik. Di samping itu, sekalipun pemberita Injili mengerjakan profesi lain tetapi sebagai hamba Tuhan penting untuk mengutamakan aktivitas yang menunjang pertumbuhan spiritual jemaat. Hal ini untuk menghindari masuknya ajaran yang tidak sehat di tengah jemaat yang bisa berakibat fatal.
Changes in human effective population size overlap the beginning and end of a critical time in European medieval history, also characterized by the Black Death epidemic
Authors: Mezzavilla Massimo , De Pizzol Federico , Vallini Leonardo , Barbiera Irene , Boattini Alessio , Taccioli Cristian , Pagani Luca
Published: August 2023

The intersection of historiography and archaeology has long pondered over the impact of known historical events on census size. In recent times, genetic methods have successfully traced changes over time in the genetic size of a given population. Moreover, the correlation between genetic and census sizes of a population is contingent on several demographic assumptions that are relatively simple for our species.
Our research endeavours to examine the changes in effective population size (Ne) in all human populations in the 1000 Genomes Project over the past two millennia. We compared our findings with estimates from historical censuses where available. Our investigation confirms what was already observed in France and reveals a common pattern found in most European populations, which manifests as a drastic population decrease beginning around the year 1300 and growth after the year 1600. This profile aligns well with known wars, famines, and epidemics that characterized these trying times in Europe. The most notable among them being the second plague epidemic, caused by Y. pestis, which in Europe commenced in 1347/8 and is also known as the "Black Death".
Our findings demonstrate that changes in genetic population size through time can serve as a dependable proxy for census size, which is independent of potential biases in the written historical record. Consequently, we provide a robust estimate of the impact caused by the population crisis that followed the year 1300 on the European genomic landscape in light of previous results. Our study offers a new paradigm for interpreting the past and underscores the potential of genetic methods in reconstructing historical events.
A LEITURA E A ESCRITA DO NOME PRÓPRIO
Authors: Michelle Pereira Girão Fernanda , Brandão Ana Carolina Perrusi
Published: August 2023

O estudo analisou situações de interação entre crianças de 3 a 6 anos e o próprio nome, registradas no cotidiano de uma instituição de Educação Infantil do Recife e como as docentes avaliavam esses momentos. Partindo de uma abordagem interpretativa (GEERTZ, 1989), identificamos experiências envolvendo a leitura e a escrita dos nomes planejadas pelas professoras e também aquelas engendradas pelas crianças. Constatamos uma descontinuidade do trabalho pedagógico com o nome ao longo da Educação Infantil, embora ele permaneça alvo da curiosidade das crianças até o final dessa etapa. Concluímos que as descobertas em torno do nome próprio podem representar uma boa oportunidade de reflexão sobre as regras e convenções do Sistema de Escrita Alfabética, tal como proposto por Ferreiro (1993, 2007).
Factors influencing voluntary tax compliance of self-employed individuals in Davao city
Authors: Maquiling Rebecca , Manolong Denise Lea Jean O , Naong Twinkle M , Sumaylo Michea Gaye C
Published: August 2023

Most self-employed taxpayers, who are exempted from third-party reporting, is being evaded. Compared to employees and corporations, self-employed have a low percentage of compliance due to government regulation focusing more on large taxpayers, resulting in fiscal imbalance. Thus, this study aims to determine the significant influence of the tax behavior factors on the tax compliance status of self-employed individuals in Davao City. The study uses descriptive-correlational method and adapted a modified questionnaire to collect data from 180 self-employed taxpayers. Findings reveal that the level of four indicators: personal, institutional, economic, and social are high than the expected level. It also shows that the level of tax compliance in terms of administration and submitting tax returns are found to be tax compliant most of the time. Using the multiple regression analysis, only institutional and social factors significantly influence tax compliance. It is recommended that the government should further strengthen the tax authority's efficiency and effectiveness while making the tax system equitable. The researchers also suggest tax forms must be convenient and tax structure must be fair and just to likely increase the number of tax returns and ensure the favorable attitude of self-employed individuals towards taxation.