bluuebunny/crossref_metadata_2025 huggingface dataset:
RESEARCH OF THE COMBINED EFFECT OF IONIZING RADIATION AND DOXORUBICIN ON HUMAN BREAST ADENOCARCINOMA CELLS OF THE MCF-7 LINE
Authors:   Obninsk Institute of Atomic Energy, Komarova Lyudmila Nikolaevna , Melnikova Anzhelika Aleksandrovna ,   Obninsk Institute of Atomic Energy, Baldov Denis Andreevich ,   Obninsk Institute of Atomic Energy
Published: June 2021

Cancer is the most common cause of death. Among them, breast cancer is the most diagnosed. Modern methods of combating malignant neoplasms are the use of radiation and chemotherapy, as well as combined treatment.
SECURITY OF USING A BANK CARD WITH ADDITIONAL PROTECTION MEASURES AND DIFFERENT FORMS OF SUBMISSION OF SMS2 / SMM2 CODE
Authors:   MSTU them. N.E. Bauman, Soloviev Nikita Romanovich , Emets Daniil Vladimirovich ,   MSTU them. N.E. Bauman, Agafonov Nikita Sergeevich ,   MSTU them. N.E. Bauman
Published: June 2021

It is difficult to imagine the modern world without a convenient opportunity to pay for goods on the Internet. However, the convenience faced the problem of stealing card data during transactions. Cybercriminals come up with more and more ways to steal money. Therefore, more advanced protection technologies must be developed. At the moment, many original solutions are offered, but they all have their advantages and disadvantages. The paper discusses some of the methods of protection and analyzes the possibility of their implementation, price, practicality and degree of protection.
Endodontic Treatment of a Mandibular Molar with Radix Paramolaris: A Case Report
Authors: Peters Ove , Ebeid Samer , Scott Raymond , Oza Shreyas , Shen Julian , Lai Gordon , Peters Ove
Published: June 2021

Anatomical variations of the root canal system of mandibular molars are common and often present challenges for endodontic treatment. In some cases, an additional root is located in the distolingual, radix entomolaris (RE), or more rarely in the buccal, radix paramolaris (RP). This case report illustrates rare nonsurgical retreatment of the complex root canal morphology of a RP and demonstrates the utility of cone-beam computed tomography (CBCT) and 3D printing in managing such a case. Underscored is the need for clinicians to understand the possible variations of root canal morphology of mandibular molars and the role CBCT imaging can play in addition to periapical radiographs in order to successfully treat a tooth with radix paramolaris.
PECULARITIES OF PEDAGOGICAL TECHNOLOGY OF PROFESSIONAL SELF-DETERMINATION OF THE CHOREOGRAPHER’S PERSONALITY DURING PROFESSIONAL TRAINING
Authors: Djan Syao
Published: June 2021

The article considers the features of pedagogical technology of professional self-determination of the choreographer’s personality during professional training. This paper states that one of the means of developing the pedagogical qualities of the student's personality in the professional training of a choreographer is the author’s pedagogical technology. We determine the relevance of the study of the pedagogical technology of professional self-determination of the choreographer during professional training by the influence of many objective and subjective factors and reveals a direct relationship between the specific historical situation in the country and the cultural needs of the population. That is why there is a need for scientific understanding of the above processes – their specifics, mechanisms, forms, methods, techniques, i.e. the entire technological chain. The article also states that no matter how perfect the technology is, it cannot take into account all the diversity of the creative process, so the unity of the technical component with the spiritual-personal and socio-pedagogical is necessary. In a living process, it is impossible to “separate” the technological subsystem, as all other components are interconnected. Therefore, it is necessary to abandon attempts to rigidly fix its scope. It is important to trace the “transition” of technology into the relationship between the subjects of the real process. Pedagogical skill is to find a technological solution for the development of the whole set of personality qualities. Methods of teaching choreographic disciplines, as a rule, are abstracted from specific concepts of personality. The construction of the technology of training choreographers involves the “selection” of those parts of the whole personality that are in the perspective of pedagogy. This means that the pedagogical interpretation of personality, having its own specifics, takes into account the knowledge of personality, which gives philosophy, psychology, sociology, but builds this knowledge as subordinates to the problems of pedagogical research.
Keywords: choreographer, professional training, professional skill, technology, pedagogical technology, technological scheme, professional self-determination, pedagogical qualities of personality.
RELATIONS BETWEEN SCIENCE AND PRACTICE IN 6TH CLASS BIOLOGY COURSE AS A CONDITION OF INTRODUCTION OF COMPETENCY-BASED TRAINING
Authors: Shapoval Larysa
Published: June 2021

The article highlights the problem of realization of the connection between theory and practice in the course of biology of the 6th grade as a condition of the competence approach to learning.It reveals the issue of developing the content of biological education, as well as the potential possibilities of the 6th grade biology course in the formation of students’ competencies that allow the application of knowledge about plants, bacteria and fungi in life.The author considers the conditions of realization of the competence approach to teaching biology from the standpoint of the connection between theory and practice.The article demonstrates that the problem of using knowledge in practice requires rethinking and bringing its content in line with modern requirements of socio-economic development of the country, science and technology.We revealed the most important concepts of polytechnic nature on the example of the topic “Root”. It can form the basis of further professional training of specialists in various fields of activity.The analysis of the 6th grade biology course allowed to purposefully identify the areas of application of polytechnic knowledge (crop production, animal husbandry, nature protection, rational use of nature, microbiological industry, medicine, etc.).The article also indicates the importance of the analysis of the effectiveness of programs and teaching aids in the implementation of a competency-based approach to school education.It figures out the main conditions for the implementation of a competency-based approach to teaching biology from the standpoint of the relationship between theory and practice. They are the following:- formation of students’ ideas about biology as a science that underlies the future profession;- formation of interest in professions related to biology as a profile discipline;- allocation of knowledge of polytechnic orientation (knowledge in the field of crop production, animal husbandry, nature protection, environmental management, microbiological industry, medicine, etc.);- selection of polytechnic material in school biology textbooks;- disclosure of causal links between the theoretical provisions of science and their applied orientation;- development of skills of application of theoretical knowledge in practice, development of ways of involvement of pupils in practical activity.
Keywords: competent approach to schooling; knowledge, skills; subject competences; 6th grade biology course; the content of biological education; polytechnic knowledge; rural schools, biology-related professions.
ESTUDO DE CASO NO ENSINO DE CIÊNCIAS: DE SUA DESCRIÇÃO À REIVINDICAÇÃO DE UMA EDUCAÇÃO QUÍMICA HUMANÍSTICA
Authors: Alves Neto Benjamim Alendino Geraldo , Simplicio de Sousa Robson
Published: June 2021

O presente estudo apresenta uma análise dos resumos de artigos que têm como tema o Estudo de Caso. O objetivo é aprender mais sobre a estratégia de Estudo de Caso em aulas de Ciências/Química. Deste modo, fazemos a pergunta “Como se mostra o Estudo de Caso nas produções da Área de Ensino de Ciências?”. Utilizamos da ferramenta de busca na Plataforma Periódicos CAPES e identificamos artigos de revistas com Qualis A1 a B2, com o escopo dedicado ao Ensino de Ciências/Química. Para a análise dos textos, foi usada a Análise Textual Discursiva (ATD). A partir da análise chegamos a duas categorias finais. A primeira nos mostrou que o Estudo de Caso nos possibilita o trabalho com temáticas investigativas, que têm um problema como foco de estudo. Na segunda categoria nos foi evidenciada a possibilidade de desenvolvimento de habilidades como a argumentação, por meio do uso de temáticas contextualizadas que buscam o fortalecimento do exercício da cidadania do aluno. Por fim, propomos a articulação dessa estratégia com elementos do Ensino de Química de modo a tornar o Ensino de Ciências e de Química mais humanizado.
Risk Factors of Postoperative Shivering at Post Anesthesia Care Unit in Normothermic Patients Underwent General Anesthesia
Authors: Rattanapittayaporn Laortip , Oofuvong Maliwan
Published: June 2021

Objective: The aim of study was to identify risk factors that can be modified to reduce incidence of postoperative shivering in normothermic patient who underwent general anesthesia.Material and Methods: A retrospective case control study was conducted between January 2017 and August 2018 by assessing the anesthetic records of normothermic patients at a post anesthesia care unit who underwent general anesthesia. A control group of 201 patients was randomly matched with 201 cases by age (±5 years) and site of surgery. Medical records were reviewed for data including patient demographics, operative time, anesthetic medication, type of fluid, core temperature at the end of surgery and occurrence of postoperative shivering. Conditional logistic regression analysis was performed to assess the association between potential risk factors and postoperative shivering.Results: Higher body mass index (BMI) [odds ratio (OR) 0.91, 95% confidence interval (CI) 0.87-0.96] and higher core temperature at end of surgery (OR 0.33 95% CI 0.18-0.63) are associated with reduced risk of postoperative shivering. Whereas emergency case compared with elective case (OR 3.06 95% CI 1.63-5.72) and longer duration every 10 minutes (OR 1.05 95% CI 1.03-1.08) are associated with an increased risk of postoperative shivering.Conclusion: Emergency case, longer duration of surgery, lower BMI and lower core temperature at end of surgery were significantly associated with postoperative shivering.
DETERMINATION OF THE SAFETY OF IRRADIATED PRODUCTS BY THE CONTENT OF QUINONES
Authors:   FSBSI ", Kurbangaleev Ya.M. ,   Federal Center for Toxicological, Radiation and Biological Safety", Vagin K.N. ,   FSBSI "Federal Center for Toxicological, Radiation and Biological Safety", Gaynutdinov T.R. ,   FSBSI "Federal Center for Toxicological, Radiation and Biological Safety", Idrisov A.M. ,   FSBSI "Federal Center for Toxicological, Radiation and Biological Safety", Ishmuhametov K.T. ,   FSBSI "Federal Center for Toxicological, Radiation and Biological Safety", Mingaleev D.N. ,   FSBSI "Federal Center for Toxicological, Radiation and Biological Safety"
Published: June 2021

The result of research, conducted using our immuno-chemical testing system (Reaction of Indirect Hemaglutination) shows that application of radiation exposure to farming and agro products in dosages needed for prolongation of their storage lifetime, for prevention of rotting and germination or for decontamination of feed-stuff from natural microflora and insects; leads to increase in radiotoxins contents thereof with maximums reached on 7-15 days. Besides, traces of radiotoxins in reaction of indirect hemaglutination depend on type of product, radiation dosage and time of product storage after radiation treatment.
HEMATOLOGICAL PROFILE OF RATS IN THE STUDY OF CUMULATIVE PROPERTIES OF NANOSTRUCTURED ZEOLITE
Authors:   FSBEI HE ", Larina Yu.V. ,   Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Kayumova L.R. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Ezhkov V.O. ,   Tatar Research Institute of Agrochemistry and Soil Science - a separate structural subdivision of the Federal State Budgetary Institution of Science "Federal Research Center" Kazan Scientific Center of the Russian Academy of Sciences ", Ezhkova A.M. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Volkov R.A. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman "
Published: June 2021

The authors of this work investigated the chronic toxicity of the feed additive. Chronic tox-icity was studied in white mongrel rats with daily intragastic administration in various doses for 28 days. The results of the studies showed that the feed additive doses not exhibit its toxic properties on the body of laboratory animals during long-term use. This experiment, no cases of intoxication and death of animals were noted. The positive effect of the drug on some indicators of morphologi-cal and biochemical parameters of blood was determined.
PROFESSOR BOHL KARL GENRIKHOVICH - PATRIARCH OF VETERINARY SCIENCE AND EDUCATION (1871-1959)
Authors:   FSBEI HE ", Ravilov R. Kh. ,   Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Nikitin I. N. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman "
Published: June 2021

The article describes the biography of Professor K. G. Bol, his scientific achievements, contribution to the development of the Kazan Veterinary Institute and the Department of Pathological Anatomy. His work is reflected in the Kazan State University, the Kazan State Institute of Advanced Training of Doctors, the Tatar Central Executive Committee, the Kazan City Council of People's Deputies.
FATTY ACID COMPOSITION OF DAIRY PRODUCTS AT THEIR MODIFICATION (FALSIFICATION)
Authors:   FSBEI HE ", Samigullin D.I. ,   Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Ezhkova A.M. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Volkov R.A. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Ezhkov V.O. ,   Tatar Research Institute of Agrochemistry and Soil Science - a separate structural subdivision of the Federal State Budgetary Institution of Science "Federal Research Center" Kazan Scientific Center of the Russian Academy of Sciences "
Published: June 2021

The article presents research on the fat of chicken, goose, lamb, beef, sour cream and a milk-containing product with a milk fat substitute, produced using sour cream technology. There is a tendency towards the absence in the composition of a milk-containing product with a milk fat substitute, butyric, nylon, capric, caprylic, decenoic acids. Fatty acids are also absent in chicken, lamb, beef and goose fats, which makes it possible to exclude the use of these fatty acids in the production of a milk-containing product.
ACTIVATION OF ADAPTOGENESIS AND STIMULATION OF GROWTH OF PIGLETS-DETACHMENTS BY TRANSPORT STRESS IMMUNOPROPHYLACTICS
Authors:   FSBEI HE ", Semenov V.G. ,   Chuvash State Agrarian University", Uspeshnyi A.V. ,   FSBEI HE "Chuvash State Agrarian University", Gladkih L.P. ,   FSBEI HE "Chuvash State Agrarian University", Tikhonov A.S. ,   FSBEI HE "Chuvash State Agrarian University", Nikitin D.A. ,   FSBEI HE "Chuvash State Agrarian University"
Published: June 2021

The purpose of this work is to realize the adaptive and productive potential of pigs with immunoprophylaxis of transport stress. Analysis of the morbidity and preservation of young pigs for the periods of growth and fattening found that immunotropic preparations PigStim-C and PigStim-M reduce morbidity, reduce recovery time and increase the effectiveness of therapeutic measures. Against the background of immunoprophylaxis, the incidence of pigs during the growth and fattening periods decreased by 4-5 %, the recovery time was reduced by 0.9-1.7 days, and the safety of pigs increased to 99 %, at 97 % in the control group. A more pronounced positive effect of the application of PigStim-C to diseases characterized by respiratory damage was revealed, and PigStim-M – the gastrointestinal tract. Prevention of transport stress by immunotropic preparations PigStim-C and PigStim-M contributed to an increase in live weight of pigs at the end of the growth period by 1.61 and 1.23 kg, respectively, more than control values, and by the end of the fattening period by 2.55 and 3.17 kg. A similar pattern was revealed in the dynamics of average daily increases in live mass. The average daily increases in the live weight of piglets against the background of the use of preparations of the PigStim series during the growth period were higher by 24.6-32.3 g, during the fattening period by 9.4-19.4 g, and on average for the growth and fattening periods by 17.0-21.2 g.
INNERVATION OF BLOOD VESSELS IN THE KIDNEYS OF THE WHITE LAB RAT
Authors:   FSBEI HE ", Tyaglova I.Yu. ,   Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Sitdikov R.I. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Mullakaev O.T. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman "
Published: June 2021

In the adventitia, there are mainly thick and medium-sized pulp fibers, the diameter of the thick nerve fibers is 0.3±0.2 mm. From the adventitia, nerve fibers penetrate into the muscle membrane, where the nerves have a large length, their diameter is 0.1±0.2 mm. There are quite a lot of soft nerve fibers lying in adventitia, in intima and media, with the presence of nuclei. The diameter of the thin nerve fibers is – 0.03±0.2 mm.
SURGICAL TREATMENT OF CONSTRICTIVE MYELOPATHY IN DOGS
Authors:   Federal State Budgetary Educational Institution of Higher Education “Moscow State Academy of Veterinary Medicine and Biotechnology - M.V. K.I. Scriabin ", Yunsi I.R.
Published: June 2021

Article describes the examination and treatment of dogs with a constrictive myelopathy (CM). CM is a degenerative pathology of the spinal cord associated with instability of the spinal column in the thoracolumbar region due to dysplasia of the caudal articular processes (aplasia or hypoplasia), which leads to microtraumas of the spinal cord and requires surgical treatment. Орerative technique was used to stabilize the spinal column by installing a system of multiaxial screws in the vertebrae with dysplasia of the caudal articular processes for the treatment of CM. Positive dynamics of neurological status was observed in 8 of 13 operated animals, in 3 patients the progression of clinical signs significantly slowed down, the neurological status of two dogs did not change after operation. The described method of stabilization of the spinal column prevents abnormal mobility of the spinal column in the area of dysplasia of the articular processes of the vertebrae. Our observations confirm that one of the causes of pia-arachnoid fibrosis is chronic spinal cord injury due to instability of the spinal column.
Makanan dan Kebiasaan Makan Ikan Sembilang (Plotosus canius) di Perairan Kota Tanjungpinang, Kepulauan Riau
Authors: Safitri Desi , Susiana Susiana , Suryanti Ani
Published: June 2021

Penelitian ini bertujuan untuk mengetahui jenis makanan, dan rasio panjang usus ikan sembilang pada perairan Kota Tanjungpinang yang meliputi index of preponderance dan indeks kepenuhan lambung. Lokasi sampling ditentukan berdasarkan metode purposive sampling dengan menetapkan 3 stasiun pengamatan dan 3 kali pengulangan yang dilaksanakan pada November 2018 sampai Maret 2019. Analisis data yang dilakukan yaitu rasio panjang usus dengan panjang total, indeks bagian terbesar, dan indeks kepenuhan lambung. Hasil penelitian menunjukkan bahwa nilai rasio panjang usus dan panjang total masing-masing pada sembilang jantan dan betina di ketiga stasiun sebesar 1,24;1,26:1,30. Index of preponderance berkisar 34,4 – 50,2%  pakan utama pada umumnya terdiri dari kelompok, kepiting, kerang, udang dan siput sehingga dapat disimpulkan ikan sembilang bersifat karnivora. Makanan pelengkap ikan sembilang dijumpai seperti detritus dan juga dari spesies Fitoplankton (Mikroalgae) yaitu Acinastrum sp. Chlorella sp. Pediastrum sp. Characium sp. Anabaena sp. Thalasionema sp. Oscillatoria sp. Ceratium sp. Peridinium sp. Navicula sp. Gyrosigma sp.
Identifikasi Efektifitas Pembelajaran Trigonometri Kelas X Masa Pandemi COVID 19 Melalui Whatsapp Group
Authors: Armiati Armiati , Budi Agung Setia
Published: June 2021

Pada masa pandemi COVID 19, sekolah diwajibkan untuk mematuhi aturan belajar dalam jaringan (daring). Tujuannya adalah untuk memutus mata rantai covid-19 dengan menjaga jarak (physical distancing). Situasi pandemi membuat guru dan pemerintah terus berupaya memberikan yang terbaik dalam menyampaikan materi pelajaraan kepada siswa secara daring. Penelitian ini bertujuan untuk mengidentifikasi efektifitas pembelajaran trigonometri di kelas X melalui whatsapp group pada masa pandemi. Penelitian dilakukan pada siswa kelas X IPA 1 di SMAN 3 Rejang Lebong. Teknik pengumpulan data dilakukan melalui wawancara dan anlisis dokumen. Teknik analisis data mengunakan statistic deskriptif. Hasil dari penelitian menunjukkan bahwa terdapat beberapa kendala dalam proses pembelajaran matematika menggunakan whatsapp group yaitu keterbatasan jaringan internet bagi siswa yang bertempat tinggal jauh dari perkotaan dan beberapa siswa yang merasa terbebani dalam memenuhi kebutuhan kuota internet. Selain itu, diperlukan bimbingan dan respons langsung (realtime response) dari guru agar dapat membantu siswa memahami materi pada saat pembelajaran melalui Whatsapp group.
Kemampuan Mahasiswa Calon Guru Dalam Mengembangkan Instrumen Tes Hasil Belajar Kategori Higher Order Thinking Skill
Authors: Izzati Nur , Febrian Febrian
Published: June 2021

Tujuan penelitian ini adalah untuk mengetahui kemampuan mahasiswa calon guru matematika dalam melakukan tahap-tahap pengembangan tes hasil belajar kategori Higher Order Thinking Skill (HOTS). Penelitian ini merupakan penelitian deskriptif. Subjek penelitian merupakan mahasiswa calon guru matematika yang mengikuti perkuliahan Evaluasi Pembelajaran Matematika. Data penelitian dikumpulkan melalui penugasan proyek. Data dinalisis disajikan secara deskriptif. Hasil penelitian menunjukkan bahwa kemampuan mahasiswa calon guru dalam mengembangkan instrumen tes kategori HOTS secara klasikal tergolong baik dengan perolehan nilai rata-rata sebesar 76,2. Kemampuan mahasiswa ini terbagi dalam tiga kategori, yaitu 32,1% termasuk kategori sangat baik, 39,3% tergolong baik, 25% tergolong cukup baik dan 3,6% termasuk kategori sangat kurang. Berdasarkan aspek kompetensi yang dinilai, rata-rata kemampuan mahasiswa tergolong baik. Pada aspek menganalisis butir soal, kemampuan mahasiswa tergolong cukup baik.
Pengembangan Perangkat Pembelajaran Berorientasi Berpikir Tingkat Tinggi Model Problem Based Learning Materi Peluang Kelas VIII SMP
Authors: Devina Prilia , Suanto Elfis , Kartini Kartini
Published: June 2021

Fokus utama tujuan pembelajaran matematika dan tuntutan kurikulum saat ini adalah mengembangkan keterampilan berpikir tingkat tinggi siswa. Sedangkan keterampilan berpikir tingkat tinggi siswa SMP terkategori cukup dan masih harus ditingkatkan. Penelitian ini bertujuan untuk menghasilkan perangkat pembelajaran matematika berorientasi berpikir tingkat tinggi berdasarkan model problem based learning yang valid pada materi Peluang kelas VIII SMP. Perangkat pembelajaran terdiri dari Silabus, Rencana Pelaksanaan Pembelajaran (RPP) dan Lembar Kerja Siswa (LKS). Penelitian ini merupakan penelitian pengembangan dengan model ADDIE. Proses pengembangan yang dilakukan pada penelitian ini hanya sampai tahap implementasi. Berdasarkan hasil analisis data diperoleh data tingkat validitas aspek Silabus, RPP, dan LKS lebih dari 60%. Hasil penelitian disimpulkan bahwa perangkat pembelajaran matematika berorientasi berpikir tingkat tinggi berdasarkan model Problem Based Learning pada materi peluang kelas VIII SMP/MTs yang dikembangkan dinyatakan valid dan dapat digunakan dalam proses pembelajaran di dalam kelas.
Analisis Kemampuan Pemecahan Masalah Siswa SMP Ditinjau dari Kemampuan Memahami, Merencana, dan Menyelesaikan Masalah
Authors: Arifin Sujinal , Zulkardi Zulkardi , Ratu Ilma Indra Putri , Hartono Yusuf
Published: June 2021

Tujuan penelitian ini adalah untuk menganalisis tentang kemampuan pemecahan masalah tipe word problems beserta factor penyebabnya. Penelitian ini menggunakan subjek siswa SMP Negeri 3 Palembang dengan jumlah siswa 19 orang. Penelitan ini merupakan penelitian deskriptif. Pengumpulan data dilakukan dengan menggunakan teknik tes dan angket. Semua data yang diperoleh secara umum dianalisis secara deskriptif kuantitatif dan kualitatif. Data kuantitatif disajikan dalam bentuk diagram batang, sedangkan data dalam bentuk kualitatif disajikan dengan cara dinarasikan. Dari hasil analisis data diperoleh informasi bahwa mayoritas siswa memahami masalah. Akan tetapi hanya beberapa siswa yang dapat menyelesaikan masalah dengan benar. Banyak siswa yang tidak membuat perencanaan dalam menyelesaikan masalah padahal perencanaan dapat digunakan sebagai jembatan dalam penggunaan informasi dan pengetahuan yang telah mereka miliki sebelumnya untuk menyelesaikan masalah. Dari hasil angket diperoleh kesimpulan bahwa ada beberapa faktor penting yang mempengaruhi keberhasilan siswa dalam menyelesaikan masalah, diantaranya adalah kemampuan dalam mengingat konsep dan teorema dalam penyelesaian masalah, suka atau tidak pada matematika, frekuensi seberapa sering latihan matematika, atau pengalaman seperti pernah menyelesaikan masalah yang sama.
Autopsie d’une tentative de résistance aux « majors »
Authors: Cuffolo Raphaël , Brée Joël
Published: June 2021

L’industrie musicale est marquée par une concentration oligopolistique desmajors. Confrontés à un marché devenu fragmenté et bouleversé par l’innovation technologique, les intermédiaires que sont les maisons de disques se sont regroupées pour devenir des conglomérats. Cette hégémonie a été perçue par une partie du public et des artistes comme menaçant la diversité et l’authenticité du rock. Les auteurs montrent comment certains artistes ont tenté de leur résister. Dans une perspective historique, leur recherche montre que la scène musicale punk constituait une forme originale de résistance. Ces artistes revendiquaient une remise en cause radicale des médiations entre artistes et intermédiaires, notamment à travers l’autoproduction.
Musique et crowdfunding
Authors: Chekkar Rahma , Renault Sophie
Published: June 2021

La recherche présentée dans cet article vise à comprendre comment sont construites les échelles de contreparties dans le cadre de campagnes de crowdfunding portant sur des projets musicaux. Les auteures se basent sur les données issues de 24 campagnes lancées sur la plateforme Ulule par 20 porteurs de projets. À partir d’une analyse des paliers proposés et contreparties associées, des recommandations sont formulées à destination des entrepreneurs musicaux désireux de mener une campagne fructueuse.
Identifier et résoudre les dilemmes de la stratégie ouverte
Authors: Nobre Thierry , Grandclaude Didier
Published: June 2021

Les travaux de recherche sur la Stratégie Ouverte (SO) étant émergents, cette recherche analyse les dilemmes découlant de l’augmentation de l’inclusion et de la transparence dans la réflexion stratégique. Durant près d’un an, les auteurs accompagnent les acteurs d’une ETI dans l’ensemble des étapes d’élaboration de leur plan stratégique en mode ouvert. Cette position privilégiée d’observateur permet d’identifier les principaux risques et difficultés qui jalonnent une démarche de SO. Pour les managers, des solutions concrètes sont développées pour anticiper et éviter ces obstacles, par la mobilisation de dispositifs méthodologiques déjà expérimentés dans l’ETI observée.
Novel Reviews
Authors: Molloy Deborah Snow , Briwa Robert M.
Published: June 2021

Ann Petry, The Street (London: Virago, 2019), 416pp., £9.99 (soft back)

Luis Alberto Urrea, The Devil’s Highway: A True Story (New York: Little, Brown and Company, 2004), xxi +239 pp. $16.99 (paperback).
DERERMINANTS OF ISLAMIC BOND MARKET REACTION Empirical Study of Islamic Bond in Indonesia
Authors: Sutrisno Sutrisno , Ningtiyas Rahayu
Published: June 2021

The main objective of this study is to examine several factors that cause islamic bonds market reaction as measured by cumulative abnormal return. The factors that are believed to be the determinants of islamic bond market reaction are the value of islamic bonds issuance, islamic bond rating, age of islamic bonds and size of the islamic bond issuing company. The population in this study are companies that issue Islamic bonds and are listed on the Indonesia Stock Exchange with a four-year observation period (2015-2018). The sample selection in this study uses purposive sampling based on certain criteria. In sample selection 36 Islamic bonds were obtained as samples. This study uses secondary data where the data is obtained from the annual report and the website of the issuing company. To test the hypothesis, using a multiple regression analysis tool with a significance level of 0.05. The results showed that the value of Islamic bonds issuance and rating of Islamic bonds issuance had a positive effect on market reaction. While the age of islamic bonds and the firm size have no effect on the reaction of the islamic bond market
Simone de Beauvoir: considerações sobre o envelhecimento e a finitude na obra Mal-entendido em Moscou
Authors: Costa Solange Aparecida de Campos
Published: June 2021

Este artigo analisa a obra Mal-entendido em Moscou de Simone de Beauvoir a partir de dois temas específicos: o envelhecimento e a finitude. O livro narra a história de André e Nicole, dois professores universitários aposentados que sentem o peso da idade ao viajar para a União Soviética pela segunda vez na vida. Assim, inicia-se uma série de mal-entendidos: a não comunicação, o medo de envelhecer, o amor de longa data, a pressuposição de uma identidade feminina, as expectativas políticas e a diferença da compreensão de mundo dos personagens. O texto trata desses desencontros principalmente do impacto do envelhecimento e a percepção da finitude para a protagonista, o que nos instiga a pensar como essas inquietações reverberam também em todos nós. O artigo se subdivide do seguinte modo; primeiro aborda de maneira geral a relação entre filosofia e literatura na produção de Beauvoir; a seguir apresenta o enredo da obra destacando alguns elementos importantes para a discussão e; por último, investiga questões sobre o envelhecimento e a facticidade, buscando entender o enfoque original que a filósofa delineia na criação corajosa e realista que faz de seus personagens.
Evaluation of miRNAs 9 and 342 expressions in sera as diagnostic and prognostic biomarkers for breast cancer
Authors: Ewida Heba A. , Shabayek Marwa , Seleem Mae
Published: June 2021

OBJECTIVE: Molecular markers for the detection of breast cancer and its different types, grades, and stages lack enough sensitivity and specificity. This study evaluates the expression of miRNAs 9 and 342 in sera of different types, grades, and stages of BC. Moreover, the assessment of their sensitivity, specificity, diagnostic, and prognostic role in detecting different types of BC. METHODS: Blood was collected from 200 females outpatients, divided into five groups each 40 subjects: control, benign breast tumor, estrogen receptor (ER+)/progesterone receptor (PR+) BC, human epidermal growth factor receptor (HER+) BC, and triple-negative BC. BC subjects were further subdivided according to grade and stage. Expressions of miRNAs 9 and 342 were measured for all subjects by real-time polymerase chain reaction (RT-PCR). RESULTS: Results showed that serum expression of both miRNAs 9 and 342 can be used for the diagnosis of different types of BC. Their expression can be used to significantly differentiate between different grades and stages of BC. MiRNAs 9 and 342 showed high sensitivity of 92.5% and specificity of (81.2 and 88.7%), respectively, for triple-negative BC. CONCLUSION: The expressions of miRNAs 9 and 342 provide potential roles as serological biomarkers for the diagnosis and prognosis of different types, grades, and stages of BC.
The value of tumor-infiltrating lymphocytes and CD8 expression as a predictor of response to anthracycline-based neoadjuvant chemotherapy in invasive breast carcinoma of no special type
Authors: Miskad Upik A. , Rifai Rizki A. , Masadah Rina , Nelwan Berti , Ahmad Djumadi , Cangara Husni , Prihantono Prihantono , Zainuddin Andi Alfian , Rahawarin Halidah
Published: June 2021

BACKGROUND: The immune system is known to play an important role in tumor cell eradication. Although cancer cells were able to escape from the immune system, many studies showed mononuclear inflammatory cell infiltrates known as tumor-infiltrating lymphocytes (TILs) on breast cancer histopathology specimens showed better prognosis, including in disease-free survival (DFS) and chemotherapy responses. OBJECTIVE: This study aimed to reveal the predictive value of tumor-infiltrating lymphocytes (TILs) levels and CD8 expression in invasive breast carcinoma of no special type patients’ samples on response to anthracycline-based neoadjuvant chemotherapy. METHODS: 75 pre-treatment biopsy samples that were diagnosed as invasive breast carcinoma of no special type were evaluated. TILs level determined following recommendations of International TILs Working Group 2014, CD8 expression assessed semiquantitatively after immunohistochemistry staining. Response to anthracycline-based neoadjuvant chemotherapy evaluated clinically using Response Evaluation Criteria in Solid Tumours (RECIST) criteria and pathologically by evaluating hematoxylin and eosin (H&E)-stained slides from mastectomy specimens after 3 or 4 cycles of neoadjuvant chemotherapy. RESULTS: Chi-squared analysis showed a significant relationship between TILs level and CD8 expression with chemotherapy responses clinically (p = 0.011 and p = 0.017 respectively) but not pathologically. Furthermore, the logistic regression test exhibit the predictive value of TILs level was 66.7% and CD8 expression was 64%. CONCLUSIONS: This study results suggest that TILs level and CD8 expression may be added as predictive factors to the response of anthracycline-based neoadjuvant chemotherapy, and oncologists may take benefit in breast cancer patient’s management.
The Quebec Questionnaire of Representations related to Work Disability (QRWoD): Cross-cultural adaptation, validity and reliability in French chronic low back pain workers
Authors: Petit Audrey , Le Borgne Margaux , Albert Valérie , Durand Marie-José
Published: June 2021

BACKGROUND: Addressing chronic low back pain (cLBP) from the point of view of representation allows better understanding the behaviors associated with it and thus improve its medical and socio-occupational management. The Quebec Questionnaire of Representations related to Work Disability (QRWoD) proposes an evaluation of 9 dimensions of the cLBP-related representation. OBJECTIVE: To translate and adapt the QRoWD to French language and assess its validity and reliability in French cLBP workers on prolonged sick leave. METHODS: A prospective study was conducted from March 2017 to April 2018 in the Department of occupational health of the University Hospital of Angers, France. The QRWoD is a self-administered questionnaire (87 items) which assesses Identity, Acute/Chronic duration, Consequences, Personal Control, Treatment Control, Cyclical Timeline, Coherence, Emotional Representation and Causes dimensions. The Internal consistency (Cronbach’s α) and the convergent validity (Pearson correlations) in comparison to validated instruments for each dimension were assed. RESULTS: Fifty French workers (29 men, 43 ± 9.1 years, 293.6 ± 173.0 days of work absence) were included. The internal consistency (all α> 0.7) and the convergent validity (all r2> 0.25, p< 0.01) of each dimension were very satisfactory except for the Cyclical Timeline dimension. CONCLUSIONS: The French version of the QRoWD seems to be valid and relevant among the target population.
Efficacy and safety of kinesiology tape for hemiplegic shoulder pain: A systematic review and meta-analysis of randomized controlled trials
Authors: Li Lingxin , Zheng Yao , He Chengqi , Zhao Yanmin
Published: June 2021

OBJECTIVE: The aim of this study was to examine the efficacy and safety of kinesiology tape in treating hemiplegic shoulder pain. METHODS: Web of Science, MEDLINE, Embase, Cochrane Library, six other English databases and three Chinese databases (CNKI, VIP, Wan Fang) were searched for randomized controlled trials published prior to December 13, 2020 in English or Chinese on the use of kinesiology tape for hemiplegic shoulder pain. RESULTS: Fourteen randomized controlled trials (679 patients) of good PEDro quality (6.43 ± 1.09) were included in this meta-analysis. The pooled results for pain (SMD -0.92, 95% CI -1.10 to -0.74, P< 0.001, 10 RCTs, 539 patients), range of motion (SMD 2.27, 95% CI 1.23 to 3.32, P< 0.001, 7 studies, 320 patients), the acromion humeral distance (SMD -0.62, 95% CI -0.88 to -0.37, P< 0.001, 7 RCTs, 246 patients) and the FMA-UE score (SMD 0.66, 95% CI 0.41 to 0.91, P< 0.001, 5 RCTs, 263 patients) suggested that therapeutic kinesiology tape relieved pain, increased ROM, shortened the acromion humeral distance and improved upper extremity motor function to a greater extent than the sham or blank control conditions. The pooled results for individual activity (SMD 0.42, 95% CI -0.22 to 1.07, P= 0.199, 5 RCTs, 199 patients) and quality of life (SMD 0.308, 95% CI -0.288 to 0.903, P= 0.311, 1 RCT, 44 patients) showed that the kinesiology tape group was not significantly different from the sham or blank control group. Publication bias was not observed. No adverse events were reported in any of the included studies. CONCLUSION: KT relieved pain and improved the ROM, DAH and FMA-UE score in patients with HSP to a greater extent than did the sham KT or blank control conditions. The effects on independence in activities of daily living and quality of life and whether this method is superior to active treatment in patients with HSP were not verified. More rigorous, reasonably designed RCTs with large sample sizes are still needed in the future.
Effects of smartphone screen viewing duration and body position on head and neck posture in elementary school children
Authors: Abdel-aziem Amr Almaz , Abdel-ghafar Mohamed Abdel-fattah , Ali Olfat Ibrahim , Abdelraouf Osama Ragaa
Published: June 2021

BACKGROUND: Electronic media have become integral parts of modern life, in which prolonged screen viewing time (SVT) by children is nearly unavoidable. Prolonged use of smartphones could lead to musculoskeletal problems. OBJECTIVES: To investigate the effect of SVT on head and neck posture during and after using smartphones for various periods of time in either standing or sitting postures. METHODS: This observational study included 34 male children aged 5–12 years who were assigned to one of two groups based on average smartphone use duration per day: group A comprised 18 children averaging > 4 hours per day (h/day) of smartphone use, and group B comprised 16 children with < 4 h/day of smartphone use. The children’s postures were photographed in standing and sitting positions while using a smartphone and 30 min after ceasing smartphone use. The head flexion, neck flexion, gaze, and craniocervical angles were measured using the software program Kinovea. RESULTS: Significant increases were found in head flexion, neck flexion, and gaze angles. Furthermore, both groups saw a significant decrease in craniocervical angle when sitting compared to when standing, both during and 30 min after smartphone use. The head flexion, neck flexion, and gaze angles of group A were significantly higher than those of group B, and the craniocervical angle of group A was significantly lower than that of group B in both postures (p< 0.05). CONCLUSION: SVT is associated with increased neck and head flexion posture in children, especially in a sitting position.
Diagnostic value of oncofetal miRNAs in cancers: A comprehensive analysis of circulating miRNAs in pan-cancers and UCB
Authors: Zhou Xin , Liu Cheng , Yin Yin , Zhang Cheng , Zou Xuan , Xia Tiansong , Geng Xiangnan , Liu Ping , Cheng Wenfang , Zhu Wei
Published: June 2021

BACKGROUND: Circulating miRNAs are promising biomarkers for detection of various cancers. As a “developmental” disorder, cancer showed great similarities with embryos. OBJECTIVE: A comprehensive analysis of circulating miRNAs in umbilical cord blood (UCB) and pan-cancers was conducted to identify circulating miRNAs with potential for cancer detection. METHODS: A total of 3831 cancer samples (2050 serum samples from 15 types of cancers and 1781 plasma samples from 13 types of cancers) and 248 UCB samples (120 serum and 128 plasma samples) with corresponding NCs from Chinese populations were analyzed via consistent experiment workflow with Exiqon panel followed by multiple-stage validation with qRT-PCR. RESULTS: Thirty-four serum and 32 plasma miRNAs were dysregulated in at least one type of cancer. Eighteen serum and 16 plasma miRNAs were related with embryos. Among them, 9 serum and 8 plasma miRNAs with consistent expression patterns between pan-cancers and UCB were identified as circulating oncofetal miRNAs. Retrospective analysis confirmed the diagnostic ability of circulating oncofetal miRNAs for specific cancers. And the oncofetal miRNAs were mainly up-regulated in tissues of pan-cancers. CONCLUSIONS: Our study might serve as bases for the potential application of the non-invasive biomarkers in the future clinical.
Dynamic positioning analysis and comfort assessment for the early design stage of large yachts
Authors: Mauro Francesco , Benci Aron , Ferrari Victor , Della Valentina Enrico
Published: June 2021

In some specific environmentally protected areas, conventional mooring systems cannot be used by large yachts for stationing at anchor and therefore, the adoption of a dynamic positioning system is required. It becomes then necessary to evaluate the station keeping capabilities of a yacht since the early-design stage. Adopting a quasi-static approach, it is possible to perform a standard capability analysis, as commonly done for the offshore industry, obtaining a capability plot as output. However, capability plots are referring to specific wind-wave correlation that are not covering all the possible wave combinations present in a sea area. Here, it is proposed to use a scatter diagram approach for the dynamic positioning analysis of a large yacht, considering the specific sea areas where the yacht shall operate, in order to figure out the downtime period of the DP system per each sea area. The proposed method can be coupled with traditional ship motions analysis, leading to a combination between comfort assessment and DP predictions. In the present work, use has been made of a traditional displacement yacht 72 m long, comparing five different DP system configurations and evaluating an enhanced comfort ranking combining ISO AWI-22834 guidelines for large yachts with ISO AWI-22822 DP analysis.
How Does Dementia Begin to Manifest in Bipolar Disorder? A Description of Prodromal Clinical and Cognitive Changes
Authors: Callahan Brandy L. , McLaren-Gradinaru Michael , Burles Ford , Iaria Giuseppe
Published: June 2021

Background: Older adults with bipolar disorder (BD) have increased dementia risk, but signs of dementia are difficult to detect in the context of pre-existing deficits inherent to BD. Objective: To identify the emergence of indicators of early dementia in BD. Methods: One hundred and fifty-nine non-demented adults with BD from the National Alzheimer’s Coordinating Center (NACC) data repository underwent annual neuropsychological assessment up to 14 years (54.0 months average follow-up). Cognitive performance was examined longitudinally with linear mixed-effects models, and yearly differences between incident dementia cases and controls were examined in the six years prior to diagnosis. Results: Forty participants (25.2%) developed dementia over the follow-up period (‘incident dementia cases’). Alzheimer’s disease was the most common presumed etiology, though this was likely a result of sampling biases within NACC. Incident dementia cases showed declining trajectories in memory, language, and speeded attention two years prior to dementia onset. Conclusion: In a sample of BD patients enriched for Alzheimer’s type dementia, prodromal dementia in BD can be detected up to two years before onset using the same cognitive tests used in psychiatrically-healthy older adults (i.e., measures of verbal recall and fluency). Cognition in the natural course of BD is generally stable, and impairment or marked decline on measures of verbal episodic memory or semantic retrieval may indicate an early neurodegenerative process.
Cerebrospinal Fluid Sulfatide Levels Lack Diagnostic Utility in the Subcortical Small Vessel Type of Dementia
Authors: Svensson Johan , Blomqvist Maria , Kettunen Petronella , Eckerström Carl , Henricsson Marcus , Jonsson Michael , Bjerke Maria , Månsson Jan-Eric , Wallin Anders
Published: June 2021

Background: Sulfatides (STs) in cerebrospinal fluid (CSF), as well as magnetic resonance imaging (MRI)-detected white matter hyperintensities (WMHs), may reflect demyelination. Here, we investigated the diagnostic utility of CSF ST levels in the subcortical small vessel type of dementia (SSVD), which is characterized by the presence of brain WMHs. Objective: To study the diagnostic utility of CSF ST levels in SSVD. Methods: This was a mono-center, cross-sectional study of SSVD (n = 16), Alzheimer’s disease (n = 40), mixed dementia (n = 27), and healthy controls (n = 33). Totally, 20 ST species were measured in CSF by liquid chromatography-mass spectrometry (LC-MS/MS). Results: CSF total ST levels, as well as CSF levels of hydroxylated and nonhydroxylated ST species, did not differ across the study groups. In contrast, CSF neurofilament light chain (NFL) levels separated the patient groups from the controls. CSF total ST level correlated with CSF/serum albumin ratio in the total study population (r = 0.64, p < 0.001) and in all individual study groups. Furthermore, CSF total ST level correlated positively with MRI-estimated WMH volume in the total study population (r = 0.30, p < 0.05), but it did not correlate with CSF NFL level. Conclusion: Although there was some relation between CSF total ST level and WMH volume, CSF ST levels were unaltered in all dementia groups compared to the controls. This suggests that CSF total ST level is a poor biomarker of demyelination in SSVD. Further studies are needed to investigate the mechanisms underlying the marked correlation between CSF total ST level and CSF/serum albumin ratio.
An Integrated Social and Behavioral System Approach to Evaluation of Healthcare Information Technology for Polychronic Conditions
Authors: Wan Thomas T.H. , Wang Bing Long
Published: June 2021

Healthcare delivery systems are evolving with the advances in health information technology (HIT) development and its applications to coordinated or guided care for polychronic conditions. The design features of artificial intelligence in healthcare reflect the public interest in optimizing care coordination and communication between providers and patients. This article offers a practical evaluation and assessment of the relevance of theoretical frameworks and appropriate methodologies to formalize a multi-criteria optimization of a logic model applicable for achieving the system’s efficiency and effectiveness. In specifying theoretical constructs and evaluation methods for HIT evaluation, a three-fold purpose is to show the relevance of personal and behavioral determinants of HIT use, articulate the need for developing a transdisciplinary framework, and formulate appropriate multilevel modeling and causal analysis of the determinants of HIT use and its impacts on chronic care.