bluuebunny/crossref_metadata_2025 huggingface dataset:
Tunable Buckling and Free Vibration of Axially Functionally Graded Graphene Origami-Enabled Auxetic Metamaterial Beams
Authors: Liu Dongying , Zhao Li , Shen Xudong , Kitipornchai Sritawat , Zhang Jing
Published: June 2024

Auxetic metamaterials have emerged as a class of advanced materials with exceptional physical and mechanical properties that are not typically found in conventional materials. This work mainly focuses on the buckling and free vibration of axially functionally graded (AFG) graphene origami (GOri)-enabled auxetic metallic metamaterial (GOEAM) beams. The beam is comprised of GOEAMs with GOri content varying through the beam length within different patterns to realize axially gradient-changing Young’s modulus, Poisson’s ratio and mass density. The material properties of AFG-GOEAMs are evaluated by using the micromechanical model including volume fraction and folding degree of GOri, geometric characteristics of graphene, material properties of matrix, and local temperature. The first-order shear deformation theory is employed to derive the governing equations via the state-space procedure, and then analytically solved with the discrete equilong segment model along beam length direction. The effects of GOri content, axial distribution pattern, folding degree and temperature on the buckling and free vibration of AFG-GOEAM beams are mainly focused on. The numerical results indicate that the development of auxetic metal metamaterials can be achieved by incorporating GOri into the metal matrix, leading to the tunable bucking and natural frequencies of AFG beams, which provide significant insights into the design of high-performance structures.
A New Analytical Approach to the Nonlinear Thermo-Mechanical Buckling Behavior of Three-Dimensional Graphene Foams-Reinforced Complexly Curved Caps and Circular Plates
Authors: Tu Bui Tien , Phuong Nguyen Thi , Ly Le Ngoc , Hung Vu Tho , Nam Vu Hoai
Published: June 2024

For the first time, the nonlinear buckling responses of shallow complex curved caps and circular plates made from three-dimensional graphene foams reinforced composite (3DGF-RC) subjected to uniformly distributed pressure and thermal loads are presented and analyzed. The four curvature types of complexly curved caps are considered to be spherical, parabolic, ellipsoid, and sinusoid caps. The governing formulations are established using the first-order shear deformation theory (FSDT) and the von Kármán geometrical nonlinearities. The trigonometric solution forms of deflection and rotation angle are proposed. The equilibrium equations in the nonlinear algebraic forms are obtained approximately by applying the Galerkin method. The results are flexibly applied to 3DGF-RC caps with complex curved shell designs in engineering. From the investigated results, it is possible to evaluate the nonlinear thermal and mechanical buckling responses of 3DGF-RC complexly curved caps and circular plates with different geometrical and material input parameters. Some useful remarks on the nonlinear buckling responses of the considered types of caps and plates can be recognized from the numerical examples. Especially, the advantage of the sinusoid caps in terms of thermal and mechanical postbuckling load-carrying capacity can be clearly observed in most investigated cases.
Railway Alignment Optimization and Seismic Responses of High-Speed Railway Bridge Considering the Spatial Effects of Mountainous-Plateau
Authors: Jiang Lizhong , Li Wei , Jiang Liqiang , Wang Zheng , Wen TianXing
Published: June 2024

Topographic effects significantly influence the propagation of seismic activity; however, research on the differences between mountainous and plateau terrains remains scarce. This paper focused on the 2008 Wenchuan earthquake, analyzing a five-span high-speed railway simply supported by a bridge through dynamic time-history analysis. Stations were categorized into mountainous and plateau groups based on their average shear wave velocity for the top 30[Formula: see text]m ([Formula: see text] values and elevation, aiming to explore the impact of terrain differences on seismic actions by comparing structural responses between the two groups. This study revealed an exponential relationship between structural responses and the rupture distance ([Formula: see text])/peak ground acceleration (PGA), with a rapid decrease in response when [Formula: see text]/PGA was below 100 and subsequent stabilization. Additionally, the sites were segmented into three zones according to the epicentral distance. The findings highlighted that the average PGA value of the mountain group was 2.7 times that of the plateau group in Region I, and the value decreased to 1.93 times that in Region II. However, the average PGA value of the plateau group slightly exceeded that of the mountain group in Region III. By comparing the PGA values of stations with similar fault distances within these regions, it was discovered that elevation could amplify seismic motion up to 4.59 times for smaller fault distances, with minimal amplification effects observed for larger fault distances. Finally, by examining damage to key components such as rails, beams, bearings, and piers and employing the kriging interpolation method to produce a regional seismic response cloud map, instances of high-speed railways constructed post-Wenchuan earthquake serve as evidence to corroborate the findings.
Lévy noise impact on a stochastic epidemic model with healing, relapse and vaccination
Authors: Abdeslami Mohamed Mouad , Basri Layla , Caraballo Tomás , Fatini Mohamed El
Published: June 2024

In this work, we propose and analyze a stochastic Susceptible-Infected-Recovered-Healed (SIRH) epidemic model with healing, relapse, and jump effects to investigate the impact of vaccination on the disease dynamics. The stochastic perturbations are introduced into the model to account for the inherent randomness in the disease transmission and recovery processes. The existence and uniqueness of the positive global solution for the stochastic model are established. Further, we study the conditions for the extinction and persistence of the disease. The impact of vaccination is incorporated into the model by considering the vaccination rate as a control parameter. Numerical simulations are carried out to illustrate the dynamical behavior of the stochastic SIRH model and to analyze the effects of vaccination on the disease spread. The graphical representations of the approximate solutions for the susceptible, infected, recovered, and healed populations are provided under different vaccination scenarios.
The stationary distribution of a stochastic heroin epidemic model with distributed delay
Authors: Zhang Xiaofeng
Published: June 2024

In view of the harm of heroin to human and society, the use and spread of heroin have been regarded as an epidemic, it is urgent for us to study and analyze the dynamical behavior of heroin epidemic model. Therefore, in this paper, we will investigate a stochastic heroin epidemic model with distributed delay. By constructing some suitable Lyapunov functions, we establish sufficient condition for the existence of a stationary distribution [Formula: see text] for the stochastic heroin epidemic model with distributed delay. Then, we analyze the theoretical results and give some suggestions to control the spread of heroin’s infectious diseases.
Automated Disentangled Sequential Recommendation with Large Language Models
Authors: Wang Xin , Chen Hong , Pan Zirui , Zhou Yuwei , Guan Chaoyu , Sun Lifeng , Zhu Wenwu
Published: June 2024

Sequential recommendation aims to recommend the next items that a target user may have interest in based on the user’s sequence of past behaviors, which has become a hot research topic in both academia and industry. In the literature, sequential recommendation adopts a Sequence-to-Item or Sequence-to-Sequence training strategy, which supervises a sequential model with a user’s next one or more behaviors as the labels and the sequence of the past behaviors as the input. However, existing powerful sequential recommendation approaches employ more and more complex deep structures such as Transformer in order to accurately capture the sequential patterns, which heavily rely on hand-crafted designs on key attention mechanism to achieve state-of-the-art performance, thus failing to automatically obtain the optimal design of attention representation architectures in various scenarios with different data. Other works on classic automated deep recommender systems only focus on traditional settings, ignoring the problem of sequential scenarios. In this article, we study the problem of automated sequential recommendation, which faces two main challenges: (1) How can we design a proper search space tailored for attention automation in sequential recommendation, and (2) How can we accurately search effective attention representation architectures considering multiple user interests reflected in the sequential behavior. To tackle these challenges, we propose an automated disentangled sequential recommendation (AutoDisenSeq) model. In particular, we employ neural architecture search (NAS) and design a search space tailored for automated attention representation in attentive intention-disentangled sequential recommendation with an expressive and efficient space complexity of

\(O(n^{2})\)

given

\(n\)

as the number of layers. We further propose a context-aware parameter sharing mechanism taking characteristics of each sub-architecture into account to enable accurate architecture performance estimations and great flexibility for disentanglement of latent intention representation. Moreover, we propose AutoDisenSeq-large language model (LLM), which utilizes the textual understanding power of LLM as a guidance to refine the candidate list for recommendation from AutoDisenSeq. We conduct extensive experiments to show that our proposed AutoDisenSeq model and AutoDisenSeq-LLM model outperform existing baseline methods on four real-world datasets in both overall recommendation and cold-start recommendation scenarios.
Towards Vietnamese Question and Answer Generation: An Empirical Study
Authors: Pham Quoc-Hung , Le Huu-Loi , Dang Nhat Minh , Tran T. Khang , Tran-Tien Manh , Dang Viet-Hung , Vu Huy-The , Nguyen Minh-Tien , Phan Xuan-Hieu
Published: June 2024

Question-answer generation (QAG) is a challenging task that generates both questions and answers from a given input paragraph context. The QAG task has recently achieved promising results thanks to the appearance of large pre-trained language models, yet, QAG models are mainly implemented in common languages, e.g., English. There still remains a gap in domain and language adaptation of these QAG models to low-resource languages such as Vietnamese. To address the gap, this article presents a large-scale and systematic study of QAG in Vietnamese. To do that, we first implement several QAG models by using the common fine-tuning techniques based on powerful pre-trained language models. We next introduce a set of instructions designed for the QAG task. These instructions are used to fine-tuned the pre-trained language and large language models. Extensive experimental results of both automatic and human evaluation on five benchmark machine reading comprehension datasets show two important points. First, the instruction-tuning method has the potential to enhance the performance of QAG models. Second, large language models trained in English need more data for fine-tuning to work well on the downstream QAG tasks of low-resource languages. We also provide a prototype system to demonstrate how our QAG models actually work. The code for fine-tuning QAG models and instructions are also made available.
Considering the Attitudes toward the COVID‐19 Vaccine, the Levels of Vaccine Hesitancy among Family Healthcare Center (FHC) Employees: A Cross‐Sectional Study
Authors: Bayram Değer Vasfiye , Yiğitalp Gülhan
Published: June 2024

Aim. The primary objective of this study was to investigate the attitudes towards the COVID‐19 vaccine, the extent of vaccine hesitancy, and the factors influencing the Family Healthcare Center staff who are responsible for delivering primary healthcare services. Methods. The research, which employed a cross‐sectional design, was carried out with a sample of 102 healthcare professionals employed at family healthcare centers located in the city center. The study data were collected using three instruments: the “Personal Information Form,” the “Vaccination Hesitancy in Pandemic Scale,” and the “Attitudes towards COVID‐19 Vaccine Scale.” Results. A total of 13.7% of the participants said that they were hesitant about having themselves vaccinated. The mean total score of vaccine hesitancy in the pandemic was found to be 22.760 ± 8.323, and the attitude towards the COVID‐19 vaccine was 3.640 ± 0.831. A negative and weak relation was detected between the total score of vaccine hesitancy and the total score of attitude towards the COVID‐19 vaccine in the pandemic. It was also found that the situation of considering the vaccine as partially necessary increases the vaccine hesitancy in the pandemic and the decrease in the degree of considering the childhood vaccines as necessary decreases the attitude towards the COVID‐19 vaccine. Discussion. Despite the relatively low prevalence of vaccination hesitancy among healthcare workers, it remains a noteworthy concern. It is imperative to conduct a thorough investigation into the various factors that contribute to vaccine hesitancy and the attitudes held by healthcare professionals, with a particular focus on those factors having a negative impact.
Prediction of the Location of Concealed Pluton on the Spatial Variation Characteristics of Volatile Matter in Coal Seams
Authors: Li Yihao , Zhao Jingui , Li Wensheng
Published: June 2024

The lower the volatile value of coal, the higher the metamorphic degree of coal. As a vector, the spatial variation of the volatilization value of the coal seam be used to explore the location of concealed pluton and to characterize the maximum influence intensity of the magma thermal field. The eastern side of the Huyanshan intrusive pluton has amassed a large amount of C‐P coal measurement and coal quality exploration data. The zonation distribution of coal seam volatile fraction data within the exploration area serves as an efficacious record of the intrusion process of the rock mass and a valuable resource for the exploration of the location of concealed plutons. Based on the data from 470 boreholes in the exploration area, contour maps of coal seams No. 02, No. 2, No. 6, No. 8, and No. 9; the true thickness contour maps of each coal layer; and the volatilizing profile map were created. The results indicate the following: (1) In the central region of the exploration area, from No. 9 to No. 8 to No. 6 to No. 2 to No. 02, the contours of volatiles in each coal seam exhibit a ring pattern, with the size of the ring and the size of the volatiles change regularly. This pattern strongly suggests that the concealed pluton is developed in the underlying layer of the coal seam. (2) According to the linear fitting of the relevant data, it is predicted that the concealed pluton is located at a depth of 65.4 m below the No. 9 coal seam. At a vertical distance of 159.1 m, the thermal field influence of the concealed pluton is lost, which aligns with the spatial distribution characteristics of volatiles in the coal seam as observed through drilling. (3) The occurrence of a significant interlayer slip between coal seam No. 6 and coal seam No. 2 in the overlying concealed pluton is indicated by the results of the hotspot migration analysis. The results are helpful to the search for magmatic‐hydrothermal deposits and the exploration and development of coal and coalbed methane.
Secuelas neurológicas tardías en la intoxicación por monóxido de carbono. Reporte de un caso pediátrico.
Authors: Cairus Rossi Andrea , Casuriaga Lamboglia Ana Laura , Baltar Yanes Federico , Giachetto Larraz Gustavo Alberto
Published: June 2024

Introducción: la intoxicación por monóxido de carbono (CO) es un problema grave de salud. La aparición de secuelas neurológicas tardías incluye trastornos cognitivos, mentales, síntomas piramidales o extrapiramidales. Caso clínico: paciente de 12 años, sexo femenino, luego de 15 días de una intoxicación aguda grave por CO, presenta movimientos coreoatetoideos de miembros superiores, distonías de cuello, discinesias de cara, bradipsiquia y dificultades en la memoria. Resonancia magnética: lesiones isquémicas en globo pálido bilateral, sustancia blanca de hipocampo y cerebelo. Discusión: es fundamental el seguimiento posterior al alta para reconocer las secuelas neurológicas tardías, incluyendo la realización de pruebas neuropsicológicas estandarizadas.
Efecto modulador de los glucocorticoides sobre la angiogénesis mediada por PI3K/Akt activada por α7-nAChR: Una revisión narrativa
Authors: Latorre de Halleux Matías , Hernández Vivanco Bastián , Carvajal Vidal Paulina , Cortés Saavedra Magdalena
Published: June 2024

Introducción: los glucocorticoides (GC) han sido ampliamente utilizados en el tratamiento de patologías oculares debido a sus efectos antiinflamatorios y anti-angiogénicos. Se ha sugerido que el mecanismo de acción antiangiogénico de los GC puede estar relacionado con la enzima fosfatidilinositol-3-cinasa (PI3K), la cual desempeña un papel crucial en la angiogénesis mediada por el receptor nicotínico de acetilcolina alfa 7 (α7-nAChR).  La PI3K es una enzima lipoproteica heterodimérica compuesta por las subunidades; reguladora (p85) y catalítica (p110). Objetivo: esta revisión examina la evidencia de la interrelación entre los GC, y la vía de señalización de PI3K activada por α7-nAChR en la angiogénesis “in vitro”. Metodología: se realizó una revisión bibliográfica utilizando los motores de búsqueda PubMed y Web of Science, relacionando los conceptos “endothelial cell”, “α7-nAChR”, “PI3K”, y “glucocorticoid”. Resultados: se seleccionaron 30 artículos que informaron sobre la expresión de α7-nAChR y PI3K en células endoteliales humanas. Además, del efecto de dexametasona sobre las subunidades de PI3K y Akt en modelos humano, murino y porcino. A partir de estos hallazgos, se propuso un mecanismo mediante el cual los GC ejercen su efecto antiangiogénico a través de la modulación en la expresión de la subunidad inhibitoria p85 de PI3K activada por α7-nAChR en células endoteliales humanas. Conclusión: los antecedentes evidencian que dexametasona, ejerce su mecanismo de acción anti-angiogénico mediante el incremento de la expresión de la subunidad inhibitoria p85 de PI3K activada por α7-nAChR. Estos hallazgos podrían contribuir a explicar la posible falla terapéutica en el área oftalmológica en pacientes fumadores.
Telerehabilitación respiratoria en fibrosis quística: experiencia de pacientes, padres y profesionales durante la pandemia de COVID-19. Estudio cualitativo.
Authors: Rodríguez Núñez Iván , Bretti María José , Daroch Neira Ana María , Zenteno Araos Daniel , Torres Puebla Gerardo
Published: June 2024

Introducción: la rehabilitación respiratoria (RR) se recomienda en pacientes con fibrosis quística (FQ). Durante la pandemia de COVID-19 los programas de RR debieron cerrarse o migrar a modalidades de telerehabilitación, imponiendo nuevos desafíos a pacientes y equipos de salud. El objetivo de este estudio fue explorar las percepciones de pacientes, padres y profesionales sobre la transición a la telerehabilitación respiratoria durante la pandemia de COVID-19. Método: estudio cualitativo. Se consideraron pacientes con FQ mayores de 8 años. También a padres y equipos de salud. El tamaño muestral se determinó mediante saturación teórica. Se realizaron entrevistas semiestructuradas y grupos focales vía Zoom ®. El análisis de datos se realizó mediante los métodos de codificación abierta y axial. El análisis se realizó utilizando el software Atlas. Ti 7.5.7. Resultados: se incluyó a 4 pacientes adultos, 1 pediátrico y 2 padres, además de 4 profesionales de equipos de salud. Existió una percepción general positiva respecto a la RR y la telerehabilitación. Entre las barreras destacó la falta de equipamiento para la telerehabilitación en domicilio y la organización diaria de los pacientes. Entre los facilitadores destacó la disponibilidad de equipos y redes que permitieran la conectividad y el apoyo familiar.  Existió una valoración positiva hacia la continuidad de la telerehabilitación en la etapa post pandémica. Conclusiones: la telerehabilitación fue percibida como una alternativa viable y efectiva, sin embargo, aspectos de la conectividad, disponibilidad de equipamiento y la rutina diaria de los pacientes debe ser considerada a la hora de implementar modalidades telemáticas de atención.
Utilización de la inteligencia artificial en cuidados intensivos
Authors: Nin Vaeza Nicolás , Gonzalez Benzano Mauricio , Castro López Ricardo
Published: June 2024

La inteligencia artificial (IA) es una disciplina de las ciencias de la computación que crea sistemas informáticos capaces de imitar la inteligencia humana y mejorar sus tareas a medida que recopilan información. En el campo de los cuidados intensivos tiene el potencial de revolucionar el cuidado, ofreciendo numerosos beneficios y mejoras en la atención al paciente. Además, la IA puede desempeñar un papel crucial en abordar los desafíos planteados por la escasez de recursos humanos calificados en este campo y el aumento de los costos asociados con esta disciplina. Este editorial examina las áreas clave donde la IA puede traer cambios sustanciales en los cuidados intensivos desde la perspectiva de los proveedores de atención médica. Nuestra intención es proporcionar una visión general de los aspectos generales en los que la IA está contribuyendo al manejo de los pacientes críticamente enfermos.
Experimental Study and Neural Network Predictions of Early-Age Behavior of Microexpansion Concrete in Large-Diameter Steel Tube Columns
Authors: Huang Shijun , Liu Zhiwei , Liu Xiaofan , Wang Zhangxuan , Li Xiaobo , Tong Teng
Published: June 2024

The improved mechanical performance of concrete-filled steel tube (CFST) components has led to their widespread application in megastructures. Therein, CFST hybrid arch bridge has become an optimal selection of large span bridges. Nonetheless, for massive concrete poured in CFST members
with large diameter, the thermal cracking and sustained rising temperature caused by early hydration heat of core concrete are urgently required to be studied. The two large-diameter CFST columns in this work, each having a diameter of 2.1 m, had their temperature and strain fields recorded
in-situ. An existing CFST arch bridge served as the model for the two CFST columns’ design. Additionally, early-age characteristics of several scaled CFST columns with varying diameters were documented. A multi-field finite element (FE) model that combines linked chemical (hydration),
heat, and mechanical fields is suggested in order to properly characterize the evolutions of temperature and strain fields. The model is validated by comparing the in-situ measurements with the numerical results. Finally, to investigate the affect factors on the hydration temperature of core
concrete in CFST columns, early-age hydration behaviors of CFST columns was simulated using the validated FE models input parameters as water to cement ratio (w/c), cement dosage, heat release of cement and diameter of CFST columns. Based on the numerical results under the input parameters
mentioned, the LSTM neural network was constructed, and the hydration temperature variances computed by FE models were selected as the input dataset. Afterwards, the temperature variance of core concrete of CFST columns was predicted using the established LSTM network. It is discovered that
the LSTM neural network that was previously constructed was able to predict the peak temperature of CFST columns as well as the hydration temperature of CFST specimens with respect to time.
Structural Design and Mechanical Properties Optimization of a Balanced Fiber-Reinforced Rubber Hose
Authors: Cheng Yu-Qiang , Gao Hua , Shuai Chang-Geng , Ma Jian-Guo
Published: June 2024

This paper focuses on the optimal design of the structure of a balanced fiber-reinforced rubber hose (RH). A multi-spherical RH is proposed. Based on the grid method, the structure optimization design of single-spherical and multi-spherical RHs is performed. According to the constraints,
the optimization results of the structural parameters of the RH are solved. Then, combined with the deformation characteristics of the conical RH, the cone-spherical RH is improved based on the spherical RH. The mechanical equilibrium angle and deformation expressions of the cone-spherical
RH are deduced. The mechanical model of the balance performance, stiffness, and burst pressure for the cone-spherical RH is constructed. The structural optimization design of double-spherical and double cone-spherical RHs is performed to further reduce the stiffness of the RH based on the
multi-spherical RH. Eventually, the correctness of the theoretical model and its optimization results is verified through experiments. The results of this research can provide reference data for future studies in related fields.
Recent Developments in the Catalytic Heterocycles Synthesis and Applications of Iron Oxide Nanomaterials
Authors: Kadam Vikas K. , Bhagat Shashikant N. , Kolekar Smita S. , Pingale Shirish S.
Published: June 2024

The synthesis of heterocyclic compounds has made extensive use of magnetic iron oxide (Fe2O3 and Fe3O4) nanoparticles as a heterogeneous catalyst. They are cheap, readily available, environmentally benign, and comparatively nontoxic catalysts.
Crucially, these nanoparticles’ surface modification allows reactivity to be tailored enabling catalysts to be designed for specific uses. Important performance for economically viable industrial processes include the easy recovery and reuse of the magnetic nanoparticles from the reaction
mixture by magnetic separation. In recent literature on catalytic applications of magnetic iron oxide NPs numerous reactions are reported viz. selective hydrogenation of nitro-heterocyclic compounds, synthesis of functionalized [1,3]-oxazoles, synthesis of benzothiazepine, spirobenzothiazine
chroman derivatives and many more. We have collected various reports from the past twelve years and compiled this review on recent trends in catalytic heterocycles synthesis and other applications of iron oxide nanomaterials.
Fabrication and Electrochemical Evaluation of Cobalt Sulfide for Energy Storage Application
Authors: Alsaad Fatimah Khalifah , Ansari Sajid Ali , Parveen Nazish , Al-Othoum Mohd Al Saleh
Published: June 2024

This work significantly contributes to this field by focusing on the synthesis and application of cobalt sulfide (CoS) as an innovative electrode material. Utilizing a straightforward hydrothermal process, we successfully synthesized CoS, emphasizing the optimization of reaction conditions.
This included a detailed exploration of different solvents, primarily water and ethanol, to determine their impact on the final product. A comprehensive characterization of these parameters was conducted, shedding light on their crucial role in the material’s performance. The electrochemical
attributes of the CoS electrodes were tested using cyclic voltammetry and galvanostatic charge discharge techniques. These investigations revealed that the CoS variant labeled as CoS_1 and CoS_2 demonstrated improved electrochemical properties. CoS_2 exhibited a specific capacitance of 360.0
Fg−1 at current load of 1.0 A/g. This superior performance of CoS_2 is largely attributed to its unique structural properties. The porous nature of CoS_2, coupled with its high surface area, plays a crucial role in enhancing its electrochemical capabilities. Furthermore, the
material displayed impressive cyclic stability, maintaining up to 82.0% of its original capacitance. This level of durability highlights its suitability for long-term applications in energy storage devices. When tested in a three-electrode assembly, both CoS_1 and CoS_2 electrodes exhibited
promising results. However, the distinct advantages of CoS_2, particularly in terms of capacitance and stability, underscore its potential as a superior candidate for energy storage applications.
Microhardness and Pushout Bond Strength of Glass Fiber Post-to-Canal Dentin Irrigated with Boric Acid, Nd: YAP, AgNPs, and Curcumin Activated with Microbubble Emulsion. A SEM, EDX Analysis
Authors: Almujel Saad H. , AlHelal Abdulaziz A. , Alsaloum Mohammed , Alzaid Abdulaziz A. , Alanazi Khalid K. , Alaqil Naif Abdulah , Al-Aali Khulud A.
Published: June 2024

This study aimed to assess the microhardness (MH) and push-out bond strength (PBS) of fiber post-to-canal dentin when boric acid (BA), Nd: YAP, silver nanoparticles (AgNPs), and microbubble emulsion (MBE) with curcumin were used as irrigants. Canal therapy was performed and the post
space was prepared. Prior to glass fiber post (GFP) insertion, the post space was irrigated using 2.5% NaOCl+17% EDTA, 10% BA+EDTA, Nd: YAP laser+EDTA, AgNP+EDTA, and MBE (curcumin)+EDTA. Following disinfection, microhardness was evaluated. GFP was then inserted and PBS was assessed at the
coronal, middle, and apical levels, along with the examination of debonded surfaces via stereomicroscope. The data were analyzed using ANOVA and a Post Hoc Tukey HSD test. The results showed that MH was highest in the group treated with AgNP+EDTA and lowest in the group treated with 10% BA+EDTA.
Within the cervical region, the Nd: YAP laser+EDTA group showed the lowest PBS, while the highest PBS was observed in the group treated with MBE (curcumin)+EDTA. In the middle region, the GFP bonded to canal dentin disinfected with 2.5% NaOCl+EDTA was comparable to that treated with Nd: YAP
laser+EDTA. In the apical region, the PBS of GFP was highest in the canal disinfected with MBE (curcumin)+EDTA. The study concluded that silver nanoparticles+EDTA and curcumin photosensitizer via microbubble emulsion+EDTA have the potential to be used as alternatives to conventional methods
for improving the adhesion of glass fiber post-to-canal dentin, along with enhancing microhardness.
Personalized Medicine in Acromegaly: The ACROFAST Study
Authors: Marques-Pamies Montserrat , Gil Joan , Sampedro-Nuñez Miguel , Valassi Elena , Biagetti Betina , Giménez-Palop Olga , Hernández Marta , Martínez Silvia , Carrato Cristina , Villar-Taibo Rocío , Araujo-Castro Marta , Blanco Concepción , Simón-Muela Inmaculada , Simó-Servat Andreu , Xifra Gemma , Vázquez Federico , Pavón Isabel , Rosado José Antonio , García-Centeno Rogelio , Zavala Roxana , Hanzu Felicia Alexandra , Mora Mireia , Aulinas Anna , Vilarrasa Nuria , Librizzi Soledad , Calatayud María , de Miguel Paz , Alvarez-Escola Cristina , Picó Antonio , Salinas Isabel , Fajardo-Montañana Carmen , Cámara Rosa , Bernabéu Ignacio , Jordà Mireia , Webb Susan M , Marazuela Mónica , Puig-Domingo Manel
Published: June 2024

Context

Medical treatment of acromegaly is currently performed through a trial-and-error approach using first-generation somatostatin receptor ligands (fgSRLs) as first-line drugs, with an effectiveness of about 50%, and subsequent drugs are indicated through clinical judgment. Some biomarkers can predict fgSRLs response.

Objective

Here we report the results of the ACROFAST study, a clinical trial in which a protocol based on predictive biomarkers of fgSRLs was evaluated.

Methods

This was a prospective trial (21 university hospitals) comparing the effectiveness and time-to-control of 2 treatment protocols during 12 months: (A) a personalized protocol in which the first options were fgSRLs as monotherapy or in combination with pegvisomant, or pegvisomant as monotherapy depending on the short acute octreotide test (sAOT) results, tumor T2 magnetic resonance (MRI) signal or immunostaining for E-cadherin; and (B) a control group with treatment always started by fgSRLs and the other drugs included after demonstrating inadequate control.

Results

Eighty-five patients participated; 45 in the personalized and 40 in the control group. More patients in the personalized protocol achieved hormonal control compared to those in the control group (78% vs 53%, P < .05). Survival analysis revealed a hazard ratio for achieving hormonal control adjusted by age and sex of 2.53 (CI, 1.30-4.80). Patients from the personalized arm were controlled in a shorter period of time (P = .01).

Conclusion

Personalized medicine is feasible using a relatively simple protocol, and it allows a higher number of patients to achieve control in a shorter period of time.
Causal Association Between BMI and Polycystic Ovarian Syndrome: Bidirectional 2-Sample Mendelian Randomization Study
Authors: Fang Yifan , Liu Lan , Yang Yingying , Zhang Bing , Xie Siqi
Published: June 2024

Objective

This study aimed to explore the causal effect of body mass index (BMI) on polycystic ovarian syndrome (PCOS).

Methods

Genome-wide association data for BMI and PCOS were sourced from the Mendelian randomization (MR) base platform. Significantly associated single nucleotide polymorphisms (SNPs) for BMI served as instrumental variables in bidirectional 2-sample MR analyses to investigate the causal relationship between BMI and PCOS. Analytical techniques utilized encompassed the inverse variance weighted (IVW) method, weighted median estimator, and MR-Egger regression.

Results

We identified 427 SNPs significantly associated with BMI (P < 5 × 10−8; linkage disequilibrium r2 < 0.001). Various methods consistently revealed a positive association between BMI and PCOS (IVW: odds ratio [OR] 2.027 [95% CI 1.599-2.596]; weighted median estimator: OR 2.368 [95% CI 1.653-3.392]; MR-Egger method: OR 3.610 [95% CI 1.795-7.263]), indicating that higher BMI correlates with an increased risk of PCOS. Additionally, we observed a causal effect of genetic predisposition to PCOS on BMI (IVW: OR 1.020 [95% CI 1.019-1.022]; weighted median estimator: OR 1.017 [95% CI 1.015-1.019]; MR-Egger method: OR 1.000 [95% CI 0.995-1.005]).

Conclusion

The MR analysis furnished compelling evidence suggesting a causal relationship between elevated BMI and the risk of PCOS, as well as indicating that the severity of PCOS may contribute to elevated BMI levels.
Approaches to Defining the Boundaries of Non-Financial Reporting
Authors: Dombrovskaya YElyena , Bykova V.
Published: June 2024

The most important stage in the preparation of non-financial reporting is the establishment of its boundaries. The lack of a set of regulated indicators and the existing practice of self-determination of disclosed issues impose requirements for the development of a methodology for selecting information. The article examines the existing approaches to setting the boundaries of non-financial reporting in Russian and international regulations and standards. The analysis of the definition of significant topics in the reporting of large domestic and foreign corporate structures is carried out.
Checking Fixed Assets for Impairment: Problems and Solutions
Authors: Krishtaleva Taisiya
Published: June 2024

All organizations must comply with current financial reporting requirements and provide investors and other stakeholders with high-quality information for decision-making. Traditionally, asset depreciation raises many questions. The impact of inflation and higher interest rates on cash flow forecasts and discount rates has led to an increase in the number of cases of impairment of fixed assets. The article discusses the problems of presenting adequate information used in impairment testing.
Tools for measuring the methodological competence of future primary school teachers
Authors: Tigrova I.
Published: June 2024

The article examines the problem of assessing the quality of training of future primary school teachers in the field of methodological training. The necessity of correlating all the requirements defined in regulatory documents (competencies, labor functions) and formulating observable and measurable educational results within the framework of the study of specific disciplines is shown. Examples of assessment tools used in studying methods of teaching mathematics to primary schoolchildren are given.
Methodological aspects of development of perception of intonational expressiveness of European music among students-vocalists of pedagogical universities of China
Authors: Zhang Yue
Published: June 2024

The article reveals methodological approaches to the development of ideas among Chinese vocal students about the intonation nature of music of the European tradition. A practical solution of methodological approaches to training Chinese vocalists is proposed, taking into account the contact of Chinese and European traditions in the educational process. The methods of pedagogy of musical education (creating an artistic context, recoding, musical generalization) are highlighted, which are aimed at developing among students the perception of the intonation expressiveness of European music and the meaningful performance of vocal works. Examples of the application of this complex of methods in vocal classes of vocal class students at Jiling Pedagogical University are given.
Review of the collective monograph "Theoretical and methodological foundations of existential pedagogy" under the scientific editorship of Doctor of Pedagogical Sciences, Professor M. I. Rozhkov (in two volumes)
Authors: Safronova E.
Published: June 2024

The monograph "Theoretical and methodological foundations of existential pedagogy" under the scientific editorship of Doctor of Pedagogical Sciences, Professor M.I. Rozhkov was prepared by a team of scientists and presented in two volumes. The scientific work reflects the results of many years of research and generalization of innovative experience in the field of existential pedagogy.
Your possibilities are limited only by your efforts!
Authors: Titova Elena
Published: June 2024

In memory of Dr. of Pedagogical Sciences, professor, academician, ex-deputy of the State Duma, head of the Center for Strategic Planning of Educational Development, expertise and Scientific Consulting of the Institute for Advanced Training and Professional Retraining of Educational Workers of the Tula region, former rector of the Tula State Pedagogical University named after L.N. Tolstoy, honorary citizen of the hero city Tula, holder of the Order of Merit for the Fatherland, II degree, author of more than 600 scientific papers on pedagogy, Member of the Editorial Boards of the journals INFRA-M - Journal of Pedagogical Research, Profile School, Nadezhda Anatolyevna Shaidenko
Ethno-cultural educational environment as a factor  in the formation of social mobility of students
Authors: Gur'yanchik V. , Makeeva T.
Published: June 2024

The article is devoted to topical issues of the formation of social mobility of students in the context of the challenges of modern reality. The authors consider the concept of "social mobility" from the point of view of the identity of the individual – civil and ethno-cultural. As a practical experience, the article presents the material of an empirical study conducted by the authors in 2022 on the basis of the Yaroslavl State Pedagogical University named after K.D. Ushinsky during the implementation of the project "University Shifts" for children from newly formed territories of Russia (Luhansk People's Republic, Donetsk People's Republic). The study involved 109 children aged 12 to 17 years with equal social status – children in a difficult life situation.
Development of creative abilities in adolescents  in the educational process of school
Authors: Rassolov M.
Published: June 2024

Based on various points of view, the article clarifies the concept of "creative abilities of adolescents", describes the main features of this phenomenon, considers the ways, opportunities and risks of organizing a cultural and educational environment in the development of creative abilities, gives a practical description of the development of creative abilities in the lessons of the basics of life safety.
Formation of lexical skills in younger schoolchildren
Authors: Filippova E.
Published: June 2024

The article is devoted to the problem of formation of lexical skills in younger schoolchildren in Russian language lessons. The author considers and analyzes the existing formulations of this concept. The proper definition of the specified term is derived. The list of lexical skills and the number of exercises in textbooks of grades 1 and 2 aimed at their formation are presented. Different types of exercises are demonstrated that allow you to organize lexical work in the lesson.
Education of patriotism among preschoolers in modern conditions
Authors: Tarasenko T.
Published: June 2024

The article deals with the actual problem of education of patriotism in older preschool children. The means are the process of familiarization with state symbols and an additional educational program «The Road of Friendship: Traveling through Russia».
Author's approaches to teaching basic economic disciplines in the context of transformation of the economic development model
Authors: Tebekin A.
Published: June 2024

The relevance of the presented research is determined by the need to change approaches to teaching basic economic disciplines adequately to the conditions of transformation of the country's economic development model.
The purpose of the presented research is to search for rational approaches to teaching basic economic disciplines that best meet the processes of transformation of national economic development. The novelty of the results obtained lies in the formation of a set of postulates for teaching basic economic disciplines in higher education in the conditions of transformation of the model of economic development of society.
The practical significance of the results obtained lies in the possibility of using the author’s approaches outlined when teaching basic economic disciplines in higher education, taking into account the processes of transformation of the model of economic development of society.
Formation of an inclusive culture of students in the conditions of the educational space of the university
Authors: Guschina Galina , Torpakova E.
Published: June 2024

Purpose of the research: study, identification and experimental verification of the levels of formation of an inclusive culture of students in the educational space of the university.
Research methods: theoretical analysis, modeling, pedagogical observation, questioning, pedagogical experiment; statistical methods of data processing (Pearson χ2 test).
Main results: the content of the inclusive culture of university students was revealed, the main stages, levels and criteria for assessing the formation of an inclusive culture of students in the educational space of the university were determined. A model for the formation of an inclusive culture of university students has been developed.
Conclusions: An inclusive culture in the educational space of a university makes it possible to fully ensure the quality of training for graduates with disabilities and disabilities, creating traditions, its effective mechanisms, with an emphasis on the formation of a value attitude of all participants in the educational process. The educational space of the university should play a leading role in the formation of an inclusive culture not only in the educational environment, but also in society as a whole.
Value of combining targeted emergency nursing with psychological nursing in children with febrile convulsions
Authors: Han Qing , Wu Feng-Ru , Hong Yun , Gu Li-Li , Zhu Yu
Published: June 2024

BACKGROUND

Febrile convulsions are a common pediatric emergency that imposes significant psychological stress on children and their families. Targeted emergency care and psychological nursing are widely applied in clinical practice, but their value and impact on the management of pediatric febrile convulsions are unclear.

AIM

To determine the impact of targeted emergency nursing combined with psychological nursing on satisfaction in children with febrile convulsions.

METHODS

Data from 111 children with febrile convulsions who received treatment at Nantong Maternal and Child Health Care Hospital between June 2021 and October 2022 were analyzed. The control group consisted of 44 children who received conventional nursing care and the research group consisted of 67 children who received targeted emergency and psychological nursing. The time to fever resolution, time to resolution of convulsions, length of hospital stays, Pittsburgh Sleep Quality Index, patient compliance, nursing satisfaction of the parents, occurrence of complications during the nursing process, and parental anxiety and depression were compared between the control and research groups. Parental anxiety and depression were assessed using the Hamilton Rating Scale for Depression (HAMD) and the Hamilton Rating Scale for Anxiety (HAMA).

RESULTS

The fever resolution, convulsion disappearance, and hospitalization times were longer in the control group compared with the research group (P < 0.0001). The time to falling asleep, sleep time, sleep quality, sleep disturbance, sleep efficiency, and daytime status scores were significantly better in the research group compared with the control group (P < 0.0001). The HAMD and HAMA scores for parents of children in the research group were lower than the scores in the control group after nursing (P < 0.05). Compliance with treatment of children in the research group was higher than in the control group (P < 0.05). Parental satisfaction with nursing in the research group was higher than in the control group (P < 0.05). The total complication rate of children in the control group was higher than in the research group (P < 0.05).

CONCLUSION

Combining psychological nursing with targeted emergency nursing improved the satisfaction of children’s families and compliance with treatment and promoted early recovery of clinical symptoms and improvement of sleep quality.
Correlation between type 2 diabetes mellitus remission and intrapancreatic fat deposition
Authors: Liu Jiang , Luo Yue , Zhu Yin-Rong , Wu Zu-Tao , Hou Yan , Xu Yu-Jie , Li Li , Ma Cun-Wen
Published: June 2024

BACKGROUND

Intrapancreatic fat deposition (IPFD) exerts a significant negative impact on patients with type 2 diabetes mellitus (T2DM), accelerates disease deterioration, and may lead to impaired β-cell quality and function.

AIM

To investigate the correlation between T2DM remission and IPFD.

METHODS

We enrolled 80 abdominally obese patients with T2DM admitted to our institution from January 2019 to October 2023, including 40 patients with weight loss-induced T2DM remission (research group) and 40 patients with short-term intensive insulin therapy-induced T2DM remission (control group). We comparatively analyzed improvements in IPFD [differential computed tomography (CT) values of the spleen and pancreas and average CT value of the pancreas]; levels of fasting blood glucose (FBG), 2-h postprandial blood glucose (2hPBG), and insulin; and homeostasis model assessment of insulin resistance (HOMA-IR) scores. Correlation analysis was performed to explore the association between T2DM remission and IPFD.

RESULTS

After treatment, the differential CT values of the spleen and pancreas, FBG, 2hPBG, and HOMA-IR in the research group were significantly lower than those before treatment and in the control group, and the average CT value of the pancreas and insulin levels were significantly higher. Correlation analysis revealed that the greater the T2DM remission, the lower the amount of IPFD.

CONCLUSION

T2DM remission and IPFD are inversely correlated.