bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetic Mechanisms Leading to Sex Differences Across Common Diseases and Anthropometric Traits
Authors: Traglia Michela , Bseiso Dina , Gusev Alexander , Adviento Brigid , Park Daniel S , Mefford Joel A , Zaitlen Noah , Weiss Lauren A
Published: December 2016

Common diseases often show sex differences in prevalence, onset, symptomology, treatment, or prognosis. Although studies have been performed to evaluate sex differences at specific SNP associations, this work aims to comprehensively survey a number of complex heritable diseases and anthropometric traits. Potential genetically encoded sex differences we investigated include differential genetic liability thresholds or distributions, gene–sex interaction at autosomal loci, major contribution of the X-chromosome, or gene–environment interactions reflected in genes responsive to androgens or estrogens. Finally, we tested the overlap between sex-differential association with anthropometric traits and disease risk. We utilized complementary approaches of assessing GWAS association enrichment and SNP-based heritability estimation to explore explicit sex differences, as well as enrichment in sex-implicated functional categories. We do not find consistent increased genetic load in the lower-prevalence sex, or a disproportionate role for the X-chromosome in disease risk, despite sex-heterogeneity on the X for several traits. We find that all anthropometric traits show less than complete correlation between the genetic contribution to males and females, and find a convincing example of autosome-wide genome-sex interaction in multiple sclerosis (P = 1 × 10−9). We also find some evidence for hormone-responsive gene enrichment, and striking evidence of the contribution of sex-differential anthropometric associations to common disease risk, implying that general mechanisms of sexual dimorphism determining secondary sex characteristics have shared effects on disease risk.
The Promiscuous sumA Missense Suppressor from Salmonella enterica Has an Intriguing Mechanism of Action
Authors: Cole Ashley E , Hani Fatmah M , Altman Ronni , Meservy Megan , Roth John R , Altman Elliot
Published: December 2016

While most missense suppressors have very narrow specificities and only suppress the allele against which they were isolated, the sumA missense suppressor from Salmonella enterica serovar Typhimurium is a promiscuous or broad-acting missense suppressor that suppresses numerous missense mutants. The sumA missense suppressor was identified as a glyV tRNA Gly3(GAU/C) missense suppressor that can recognize GAU or GAC aspartic acid codons and insert a glycine amino acid instead of aspartic acid. In addition to rescuing missense mutants caused by glycine to aspartic acid changes as expected, sumA could also rescue a number of other missense mutants as well by changing a neighboring (contacting) aspartic acid to glycine, which compensated for the other amino acid change. Thus the ability of sumA to rescue numerous missense mutants was due in part to the large number of glycine codons in genes that can be mutated to an aspartic acid codon and in part to the general tolerability and/or preference for glycine amino acids in proteins. Because the glyV tRNA Gly3(GAU/C) missense suppressor has also been extensively characterized in Escherichia coli as the mutA mutator, we demonstrated that all gain-of-function mutants isolated in a glyV tRNA Gly3(GAU/C) missense suppressor are transferable to a wild-type background and thus the increased mutation rates, which occur in glyV tRNA Gly3(GAU/C) missense suppressors, are not due to the suppression of these mutants.
Dyslipidemia in patients with arterial hypertension and extrasystoles
Authors: Didyc N. V.
Published: December 2016

The significant incidence of hypertensive disease among the Ukrainian population makes the search for new methods of management and treatment of patients suffering from this pathology a matter of high priority. Our research is focused on study of changes of some biochemical parameters in patients suffering from hypertensive disease as well as patients suffering from hypertensive disease and coexistent extrasystoles. Arterial hypertension leads to different structural and functional changes in the cardiovascular system. In many patients these changes may result in rhythm disorders. 120 patients have been examined (42 men and 78 women) between the ages of 27 to 81 (average 59.8) suffering from hypertensive disease of the II stage as defined by the Ukrainian Association of Cardiologists and from extrasystoles (more than 30 episodes per hour of research) of different topography and 30 persons (13 men and 17 women) suffering from hypertensive disease of the II stage between the ages 30 to 76 (average 56.4) without rhythm disturbance). The first clinical group was formed by 54 (45%) patients suffering from repeated supraventricular extrasystoles (SE) (average 62 ± 2 SE per hour of research). The second clinical group was formed by 42 (35%) patients suffering from repeated ventricular arhythmia (VA) (average 37 ± 2 VA per hour of research). The third group was formed by 24 (20%) patients suffering from both repeated SE and VA (average 48 ± 3 SE and 32 ± 3 VA per hour of research). We conducted 24 hours’ monitoring of blood pressure and electrocardiography using the “Dia Card”-system (“Solvaig”, Ukraine) for all patients. This revealed that ventricle extrasystoles and combined extrasystoles in patients with essential hypertension, II stage are associated with more unfavourable changes in 24 hours’ profile of blood pressure. The paper analyses the cardiac arhythmia structure of heart rate variability in patients with arterial hypertension (AH) and extrasystoles. The findings confirmed the presence of desynchronization in the activity of the neurohnmoral system. Thus, different mechanisms of arhythmogenesis were revealed in patients with arterial hypertension. In the results, frequent ventricular and combined extrasystoles were associated with an unfavourable blood pressure profile during 24-hours monitoring as well as higher end-diastolic left ventricular volume, diastolic dysfunction, aortic valve fibrosis, aorta remodeling, endothelial dysfunction and more prominent lipid disorders. Supraventricular extrasystoles were associated with hypertriglyceridemia, left ventricular diastolic dysfunction and left atrium enlargement.
Pancreatic response of spontaneously hypertensive rats to the exogenous administration of melatonin in the spring and autumn
Authors: Yanko R. , Berezovsky V. , Levashov M. , Plotnikova L. , Chaka O.
Published: December 2016

The aim of the study was to investigate and compare the effect of exogenous melatonin administration on the morphofunctional state of the exocrine and endocrine parts of the pancreases of spontaneously-hypertensive rats (SHR line) in spring and autumn. The research was conducted on 48 male SHR line rats, age 4 months. The rats of the experimental group received melatonin (Unipharm Inc.,USA) every day (at 10 am) orally at a dose of 5 mg/kg of body weight. The duration of the experiment was 28 days. Morphofunctional activity of the exocrine and endocrine parts of the pancreas was assessed using morphological and morphometric methods. The histological preparations were made by the standard methods. The slides were photographed using a digital camera on a Nikon microscope. The morphometric analysis was performed on digital images using the computer program Image J. The morphological signs of the exocrine pancreas activity were greater in the control rats in spring compared to autumn. Conversely, the activity of the endocrine part of the pancreas in control animals was higher in autumn, than in spring. Exocrine pancreas activity increases after administration of melatonin regardless of time of the year. This was evidenced by the increase in size and height of the epithelial acini, and the number of exocrinocytes placed in them. The width of the interlobular and interacinus connective tissue layers in the pancreas decreased in spring (mostly) and in autumn. The activity of the endocrine part of the pancreas increased after administration of melatonin in spring. Proof of this was an increase in the number and size of islets of Langerhans and the number of endocrinocytes they contained, compared with control values. The number and size of islets of Langerhans, the number and density of the endocrinocytes they contained decreased in the rats which received melatonin in autumn. This indicates a reduction of the endocrine pancreas activity. These results may have implications for therapeutic dosing of melatonin in patients with hypertension in different seasons of the year.
Association of group erythrocyte antigens and B-cell non-Hodgkin lymphoma
Authors: Tymoshenko U. V. , Sivkovych S. O. , Garkava K. G. , Pavlyuk R. P. , Myronenko G. A.
Published: December 2016

We analyzed the frequency distribution of blood groups AB0, Rhesus and Kell in patients with B-cell non-Hodgkin lymphoma. An increase of D− patients (31.0%) among ill in comparison to healthy individuals (16.5%) was found. Based on published data, we exclude weakening or alteration of the D antigen for this pathology. We found an association of B-cell non-Hodgkin lymphoma and D− phenotype. It is established that the chances of developing the disease in D− individuals is 2 times higher than for D+ individuals. However, we did not find a significant association of frequency of minor antigens Rhesus (C, c, E, e, CW), K antigen Kell system, A and B antigens AB0 system and the development of B-cell non-Hodgkin lymphoma. We have analyzed the statistics of incidence of non-Hodgkin lymphoma inWestern Europeand Asian countries. We noticed a roughly twofold increase in the incidence of non-Hodgkin lymphoma inWestern Europecompared to Asian countries, where the proportion of D− individuals is almost zero. Parallel with the results of our study, it has been found that the chances of D– persons developing B-cell non-Hodgkin lymphoma are twice as high as for D+ individuals. InUkraine,BelarusandRussiathe incidence of non-Hodgkin lymphoma is almost at the level of Asian countries even though the percentage of D– individuals corresponds to Western European countries (15–16%). This can be explained by other genetic factors, or reduction in quality of care and diagnostics in post-Soviet countries compared toWestern Europe. Thus, D antigen may have a protective role in the morbidity of non-Hodgkin lymphoma.
Efectos de la conectividad local sobre los ensambles de peces en una planicie de inundación tropical
Authors: Gutiérrez-C. Ángela L. , Pinilla-A. Gabriel A.
Published: December 2016

Las lagunas de las planicies de inundación tropicales albergan alta diversidad biológica, son fundamentales para los ciclos de vida de muchos organismos y de importancia económica para las poblaciones locales. Este estudio evaluó el efecto de la conectividad local en los ensambles de peces en las lagunas San Silvestre (conectividad alterada) y El Llanito (conectividad no alterada), en la planicie de inundación del río Sogamoso, afluente del río Magdalena, Colombia. Se realizaron tres muestreos durante un ciclo hidrológico y se analizaron la abundancia, riqueza y equidad de los ensambles de peces y los aspectos fisicoquímicos de las lagunas. Se registraron 37 especies, 28 en El Llanito y 31 en San Silvestre. Aunque no se encontraron diferencias en los índices de riqueza y equitatividad, hay tendencias claras que indican menores valores en San Silvestre comparada con El Llanito. No hubo diferencias en la abundancia entre las lagunas, pero fue mayor y con poca variación en San Silvestre, mientras que en El Llanito hubo un pico en el último muestreo. En las dos lagunas las abundancias se concentraron en pocos taxones con variaciones temporales moderadas. En El Llanito la temperatura, el pH y la conductividad fueron mayores, mientras que en San Silvestre los valores fueron más elevados en profundidad y velocidad de la corriente. Los resultados pueden ser útiles para la conservación de los recursos ícticos dada su importancia social y ecológica para esta cuenca que está sometida a una gran presión por las actividades humanas.
Diversidad florística del Paisaje Natural Protegido “Estrella-Aguadores”, Santiago de Cuba, Cuba
Authors: Castell-Puchades Miguel Ángel , Almarales-Castro Abel , Acosta-Cantillo Félix , Lafargue-Hechavarría Sandra
Published: December 2016

El Paisaje Natural Protegido “Estrella-Aguadores” se considera entre las áreas de mayor riqueza florística de la costa suroriental de Cuba, sin embargo, son insuficientes los estudios florísticos locales que les posibilite a técnicos y decisores locales contar con la información necesaria para emprender acciones adecuadas de conservación y manejo; con el objetivo de resolver este problema, realizamos un estudio de la diversidad florística que caracteriza el área protegida. Se desarrolló un muestreo preferencial, sin rumbo fijo, teniendo en cuenta en cada recorrido las características físico-geográficas del área, así como la ecología de las especies. El trabajo de campo se realizó según la metodología de los inventarios biológicos rápidos. Se identifican 266 especies de angiospermas para el Paisaje Natural Protegido “Estrella-Aguadores”, de las cuales 112 constituyen nuevos registros para el área protegida. Se registran 38 especies endémicas y seis especies amenazadas. El 48% de las angiospermas registradas presentan algún tipo de uso o valor para los comunitarios. Este trabajo muestra al Paisaje Natural Protegido “Estrella-Aguadores” como una de las reservas más importantes en diversidad de angiospermas de las terrazas costeras de Cuba, lo cual resalta su función como área de protección de la flora.
Atención temprana, percepción de madres de niños y niñas con Síndrome de Down
Authors: Tapia-Gutiérrez Carmen Paz , Palma-Mardones Andrea , González-Parra Karla
Published: December 2016

Las actuales investigaciones en el área de la atención temprana enfatizan la necesidad de avanzar hacia modelos de atención que permitan la participación activa de la familia. A partir de ello, se planteó un estudio que tuvo como objetivo describir las dimensiones de atención temprana relevantes para familias de niños y niñas con síndrome de Down, que participaron en los talleres del Centro de Evaluación y Atención Temprana Universitaria. Se trata de una investigación evaluativa con enfoque cualitativo que utilizó un diseño de estudio de casos en el que participaron cuatro madres a quienes se les realizaron entrevistas semiestructuradas y, posteriormente, a dos de ellas, en profundidad. Los resultados informan dos dimensiones, (1) Características profesionales, referido al trabajo interdisciplinario, compromiso profesional y componente humano, y (2) Modos e instancias de participación, se valoran los talleres como un espacio de socialización para niños, niñas y madres, en el que ellas aprenden, relatan experiencias vividas y avanzan en autonomía. Los hallazgos permiten concluir que el modelo de atención considera adecuadas competencias profesionales y prácticas que se sitúan en un primer nivel de participación. De esta manera, se concluye que los talleres planteados dan cuenta de un modelo de familia-aliada. Lo anterior abre un espacio para repensar las prácticas de los profesionales en los centros especializados de atención temprana, así como en las instituciones formadoras, para favorecer el empoderamiento, la participación y autonomía que promueven los modelos centrados en la familia.
Comparación entre rendimiento académico, autoeficacia y práctica deportiva en universitarios
Authors: Oropeza Tena Roberto , Ávalos Latorre María Luisa , Ferreyra Murillo Diego Agustín
Published: December 2016

El presente trabajo muestra los resultados de una investigación cuantitativa, transversal y analítica que tuvo por objetivo identificar si existen diferencias entre universitarios (hombres y mujeres) con y sin práctica deportiva en rendimiento académico (promedio de calificaciones y calificaciones en asignaturas) y autoeficacia. A pesar de que el rendimiento académico y la autoeficacia son considerados como algunas de las dimensiones multifactoriales más importantes en el ámbito educativo, son escasas las investigaciones que comparan las diferencias entre quien practica o no algún deporte. Participaron 331 estudiantes (72 hombres y 259 mujeres) de la Facultad de Psicología de una universidad pública de México. Se recabaron datos sociodemográficos mediante una ficha de identificación. Se diseñó y aplicó un inventario de actividades académicas y extra académicas; asimismo el inventario de autoeficacia general; y se obtuvo la boleta de calificaciones de cada participante. Se encontró una diferencia estadísticamente significativa entre el rendimiento académico (T = 1.801, p<.005) y autoeficacia (T = -3.063, p<0.003) al comparar a los participantes que practican actividades deportivas y los que no; así como con el promedio de calificaciones de algunas asignaturas en aquellos que practicaban sistemáticamente algún deporte. No se observan diferencias estadísticamente significativas entre hombres y mujeres en cuanto al tiempo de práctica de alguna actividad física, resulta necesario profundizar en investigaciones al respecto. A partir de los hallazgos, se considera que practicar alguna actividad física influye positivamente tanto en el rendimiento académico como en la autoeficacia de los estudiantes, ya que fomenta la disciplina, estilo de vida saludable y ayuda a tener un buen rendimiento académico. Es recomendable ampliar este tipo de investigaciones a estudiantes de otras disciplinas, así como equilibrar la cantidad de hombres y mujeres ya que los hallazgos encontrados pueden deberse a que la muestra fue predominantemente femenina o a la carrera que estudiaban.
Enseñanza de la Anatomía con base en el enfoque de Aprendizaje Basado en Problemas mediante casos clínicos
Authors: Miranda Chacón Zaray
Published: December 2016

En este artículo se presentan los resultados de investigación al implementar un método didáctico innovador para la docencia en anatomía, mediante un laboratorio de aprendizaje basado en problemas clínicos dentro de los cursos de anatomía para medicina, la propuesta se introdujo como parte de los laboratorios de los cursos Anatomía Descriptiva y Anatomía Topográfica, Radiológica y Clínico-Quirúrgica durante el 2014 en la Universidad de Costa Rica. Se realizó un estudio descriptivo en el cual se indagó la opinión del estudiantado con respecto a la implementación del método y la evaluación de este mediante una escala de Likert, con opiniones positivas de parte de este en los distintos rubros evaluados. Se encontraron coincidencias con los resultados obtenidos y los distintos referentes teóricos consultados.El cuerpo estudiantil tuvo opiniones positivas con respecto a que el Aprendizaje Basado en Problemas ayuda a la construcción del conocimiento, promueve el trabajo grupal y permite una identificación con la futura práctica profesional.
The Evolution of Efficiency in Costa Rican Banking System 2005-2015: Evidence from Data Envelopment Analysis
Authors: Salas-Alvarado Andrés
Published: December 2016

In this study the technical and scale efficiency of Costa Rican banking system is estimated for the 2005-2015 period, through the Data Envelopment Analysis (DEA). The estimations are within the approach of variable returns to scale with slacks developed by Banker, Charnes, and Cooper (1984) and the constant returns to scale approach developed by Charnes, Cooper, and Rhodes (1978). Efficiency scores were estimated annually for each bank to get the average for state banks, private banks, and the whole system. The inputs and outputs considered in the DEA model were defined through the intermediation approach. Through the application of DEA was concluded that a) for the whole system there are no clear efficiency improvements during the period analyzed, b) the most efficient banks were Banco BCT and Banco General, c) private banks were on average more efficient than state banks and d) the goods of net use were, on average, the input with bigger slack.
Better off without the euro? Evaluating monetary policy and macroeconomic performance for the u.k. and sweden
Authors: Krause Montalbert Stefan
Published: December 2016

En este artículo comparo los resultados macroeconómicos, medidos por la volatilidad del PIB real y la inflación, para dos de los países que optaron por no entrar en la UEM: el Reino Unido y Suecia. En particular, estoy interesado en saber cuánto de los cambios en el desempeño macroeconómicos experimentados por el Reino Unido y Suecia después de 1999 se debe al aumento de la eficiencia en la conducción de la política monetaria independiente. El objetivo es analizar los cambios en la volatilidad macroeconómica que se podrían haber alcanzado si estos dos países hubieran adoptado el Euro a partir de enero de 1999.
Arte y cultura masónica en el México barroco
Authors: Fernández Martha
Published: December 2016

A pesar de su importancia, la masonería en el arte del México barroco es un tema ausente en la historiografía, no obstante, existen elementos suficientes para pensar que pese a todos los obstáculos que enfrentaron, artistas y sociedad pudieron vincularse con la cultura masónica desde finales del siglo XVII y principios del siglo XVIII. Conceptos como el del Gran Arquitecto del Universo, la representación de los Santos Coronados, la presencia de símbolos iconográficos como la escuadra, el compás y la plomada, así como el retrato de un arquitecto novohispano como maestro masón, nos llevan a considerar esa posibilidad. Todo ello, dentro de un contexto artístico y social en el que deben tomarse en cuenta la crisis gremial y la existencia de una cofradía titulada de Nuestra Señora de los Gozos y Santos Architectos. En este artículo presento avances de una investigación más amplia que desarrollo en torno a ese tema.
Soldados orientalistas: teosofía y masonería en el Magreb durante la II República Española
Authors: Aguiar Bobet Valeria
Published: December 2016

La vinculación entre masonería y teosofía ha sido objeto de distintos análisis por parte de la historiografía, sobre todo porque muchos masones españoles pertenecieron a su vez a distintos movimientos y asociaciones teosóficas que se expandieron y constituyeron por todo el territorio nacional desde finales del siglo XIX. Sin embargo, en el Protectorado español de Marruecos, la mayor parte de los integrantes y simpatizantes de la Sociedad Teosófica no solo fueron masones y teósofos, sino que fueron militares de diferente graduación. El propósito de este trabajo es, precisamente, aproximarnos a la relación entre este trinomio particular, la masonería, la teosofía y el estamento militar, a partir del análisis ideológico de las prácticas y discursos de aquellos miembros de esta asociación. Sin olvidar, por un lado, cómo se estructuró y definió esta interrelación ideológica en el contexto republicano y colonial de marcado carácter militar, y, por otra, cómo influyó en los procesos sociopolíticos que vivía España y su Protectorado en los años previos a la Guerra Civil.
Esoterismo y poder en Castilla y Aragón. Enrique de Villena y su Tratado de la Fascinación (1425) y Tratado de Astrología (1438)
Authors: Villalba Mariano
Published: December 2016

El investigador Mariano Villalba ha defendido una Tesis de Maestría en Sociología de la Cultura y Análisis Cultural, cuyo título es “Esoterismo y poder en Castilla y Aragón. Enrique de Villena y su Tratado de la Fascinación (1425) y Tratado de Astrología (1438)” en el Instituto de Altos Estudios Sociales de la Universidad Nacional General San Martín, Buenos Aires, Argentina, el 3 de Mayo de 2016.
Espectros de Nueva York de José Ricardo Chaves
Authors: Rodríguez Cascante Francisco
Published: December 2016

Espectros de Nueva York de José Ricardo Chaves. San José: Editorial Costa Rica. 2015. 228 páginas. ISBN: 978-993051908.
„Libertae isdem coniugi T. Licinius”. Az idem névmás megkövesedésének problematikája
Authors: Zelenai Nóra
Published: December 2016

Elsősorban római feliratokon találkozhatunk azzal a jelenséggel, hogy az idem névmás hímnem nominativusban tűnik fel olyan helyeken, ahol másik nem, más eset (általában dativus) vagy adverbium lenne indokolt. A feliratgyűjtemények az idem alakokat általában adverbiumként értelmezik, és itemre javítják. E. H. Sturtevant viszont azt állítja, hogy míg Ostiában az idem alakok az item adverbium helyi, dialektális változatai, ugyanezeket az alakokat Rómában tudatosan használt nominativusnak kell tekintenünk. A tanulmány Sturtevant elméletének kritikai vizsgálatával az idem névmás megkövesedésének és az item adverbiummal való esetleges összeolvadásának kérdésével foglalkozik.
Simple prediction model for unfavorable outcome in ischemic stroke after intravenous thrombolytic therapy
Authors: Amitrano Daniel , Silva Ivan Rocha Ferreira da , Liberato Bernardo B. , Batistella Valéria , Oliveira Janaina , Nascimento Osvaldo J. M.
Published: December 2016

ABSTRACT Objective We aimed to develop a model to predict unfavorable outcome in patients with acute ischemic stroke treated with intravenous thrombolytic therapy (IVT), based on simple variables present on admission. Methods Retrospective analysis of acute ischemic stroke patients treated with IVT in a hospital in Rio de Janeiro. Clinical and radiographic variables were selected for analysis. Multivariate logistic regression was used to develop a predictive model. Results We analyzed a total of 82 patients. Median National Institutes of Health Stroke Scale (NIHSS) on admission was 9 (3–22), 40.2% presented with a hyperdense artery sign (HAS), 62% had identifiable early parenchymal changes and 61.6% experienced a favorable outcome. An NIHSS score of > 12 on arrival, age > 70 and the presence of HAS were associated with the outcome, even after correction in a logistic regression model. Conclusion An NIHSS > 12 on arrival, presence of HAS and age > 70 years were predictors of unfavorable outcome at three months in patients with acute ischemic stroke treated with IVT.
Migraine in the post-menopausal period is associated with higher levels of mood disorders, disability, and more menopausal symptoms
Authors: Carturan Paula , Scorcine Claudio , Fragoso Yara Dadalti
Published: December 2016

ABSTRACT Objective To assess the prevalence of headache in post-menopausal women. Methods Women attending gynecology outpatient services in the coastal region of the state of Sao Paulo, Brazil were invited to participate in this study. Only those with non-surgical menopause and no hormone replacement therapy were included. Prevalence and characterization of headaches were assessed, as well as the burden of migraine, traits of anxiety and depression, and menopausal symptomatology. Results One hundred and three women were included in the study. Migraine affected 14.7% of them. Some previous type of headache was reported by 86.2% of the women, most of whom improved during menopause but still presented with headache attacks. There was a correlation between higher migraine disability and depressive traits. Conclusions Many women believe that their headaches, particularly migraine, will end after menopause. This is, unfortunately, not the case for many of them.
Refractory epilepsy in children with brain tumors. The urgency of neurosurgery
Authors: Bernardino Marília Rosa Abtibol , Funayama Carolina , Hamad Ana Paula Andrade , Machado Hélio , Sakamoto Américo , Thome Ursula , Terra Vera Cristina , Santos Antonio Carlos dos , Serafani Luciano Nader , Calixto Nathalia Cunha , Silva Huria Shalom Monturil de Carvalho
Published: December 2016

ABSTRACT In order to verify indications for surgery, 27 patients with refractory epileptic seizures and brain tumor, aged up to 19 years at the time of surgery, were studied between 1996 and 2013 and followed up for at least one year. The mean interval between the onset of seizures and the diagnosis of the tumor was 3.6 years, and from diagnosis to the surgery, 18 months. The location of the tumor was in the temporal lobe in 16, with ganglioglioma and dysembryoplastic neuroepithelial tumors being the most frequent. Among the patients, 92.5% and 90.4% were seizure-free in the first and fifth year after surgery, respectively. Twelve of 16 children were successful in becoming drug-free, with complete withdrawal by 3.2 years. Surgery proved to be potentially curative and safe in these cases, suggesting that the tumor diagnosis and surgery cannot be postponed.
Attention deficit hyperactivity disorder and drug addiction rehabilitation patients
Authors: Camargo Carlos Henrique Ferreira , Dornelles Tarcísio Fanha , Barszcz Karin , Martins Eduardo Antunes
Published: December 2016

ABSTRACT Objective Attention deficit hyperactivity disorder (ADHD) is characterized by a persistent pattern of inattention or hyperactivity. This study aimed to investigate the relationship between ADHD and drug dependence. Methods The presence and severity of ADHD and substance use were evaluated through questionnaires in 80 adult patients in therapeutic communities. Results No difference in drug use or dependence prevalence between ADHD and non-ADHD patients was found. However, ADHD patients had lower ages on admission (p = 0.004) and at first contact with cocaine (p = 0.033). In ADHD patients, there was a negative correlation between the age at first use of cannabis and the subsequent severity of cannabis use (p = 0.017) and cocaine use (p = 0.033). Conclusions Though there was no difference in prevalence of drug use among groups, results show that ADHD in patients in therapeutic communities may cause different addiction patterns, such as earlier use of cocaine and admission, and a more severe use of cocaine correlated to earlier contact with cannabis.
GENETIC DIVERGENCE AMONG Passiflora cristalina Vanderpl & Zappi. GENOTYPES BASED ON FLOWER AND FRUIT CHARACTERISTICS
Authors: SILVEIRA GREICIELE FARIAS DA , ROSSI ANA APARECIDA BANDINI , VARELLA TATIANE LEMOS , CARVALHO MAURECILNE LEMES DA SILVA , SILVA CAROLINA JOANA DA
Published: December 2016

ABSTRACT This study aimed to evaluate the genetic divergence among Passiflora cristalina genotypes and quantify the relative contribution of 30 flower and fruit characteristics, seeking to support the preservation and characterization of genetic resources of the species for preservation and use in future breeding programs. We evaluated 150 fruit and 150 flowers collected in 15 genotypes with naturally occurring in the municipality of Alta Floresta, MT. The characterization of genotypes was performed through 30 morphological characteristics of flowers and fruits, 21 of these for flower and 9 for fruit. Data were evaluated using the principal components and cluster methods obtained by UPGMA method from the similarity matrix (Euclidian mean distance), using the Genes software. By principal component analysis, it has been found that the first three components have absorbed 52.11% of the accumulated variation. The characteristics that most contributed to the discrimination of genotypes were fresh fruit weight, stigma length, length of corona filaments, fruit width, petal width and pulp weight, which are more responsive for the selection of P.cristalina genotypes. Smaller contributions to diversity were obtained from anther width, bract width and fruit length. The smallest contributions for diversity were obtained from the following characteristics: anther width, bract width and fruit length. Through UPGMA clustering method, it was found that there is a large genetic divergence among genotypes analyzed because all genotypes were grouped with over 50% of dissimilarity. This study identified genotypes 4, 5 and 9 as the most divergent and therefore the most suitable for breeding in future breeding programs and genetic conservation of the species.
PERFORMANCE OF ‘NANICÃO JANGADA’ BANANA PLANTS INTERCROPPED WITH WINTER COVER CROPS
Authors: AGUIAR RICARDO SFEIR DE , ZACCHEO PAULO VICENTE CONTADOR , NEVES CARMEN SILVIA VIEIRA JANEIRO , AGUIAR MARCELO SFEIR DE , OLIVEIRA FERNANDO TEIXEIRA DE
Published: December 2016

ABSTRACT The use of cover crops species may be an important strategy in the pursuit of sustainability of agroecosystems, considering benefits to soil, such as improvements of physical and chemical characteristics, and weed control. The objective of this study was to evaluate the effect of winter cover crops and other soil managements on chemical soil properties, on the cycle, on the production of the first cycle and on the fruit quality of banana cv. Nanicão Jangada in Andirá – PR, Brazil. The experiment was carried out in a commercial. Planting of banana suckers from the grower area occurred in the first half of March 2011, with a spacing of 2.40 m between rows and 1.90 m between plants. The experiment was designed in randomized blocks with four replications and six plants per plot. The six treatments were: black oat (Avenastrigosa Schreb), forage turnip (Raphanus sativus L. var. oleiferus), consortium of black oat and forage turnip, chicken litter, residues of banana plants, and bare ground. The evaluations were vegetative development and life cycle of banana plants, yield and quality of fruits, soil chemical characterstics, and fresh and dry mass of green manures. The results were submitted to ANOVA (F Test), and Tukey test at 5 % probability. Black oat and black oat with forage turnip consortium were superior in biomass production. Systems of soil management had no effect on the variables, except in the periods between planting and flowering and between planting and harvest, which were shorter in the treatment of soil management with crop residues, longer in the treatment with forage turnip, and intermediate in the other treatments.
DETERMINATION OF THE FATTY ACID PROFILE IN Eugenia dysenterica DC. SEEDS
Authors: CAMILO YANUZI MARA VARGAS , SOUZA ELI REGINA BARBOZA DE , NAVES RONALDO VELOSO , VERA ROSÂNGELA , VIEIRA MUZA DO CARMO
Published: December 2016

ABSTRACT The present research aimed to determine the fatty acid profile in the seed oil of cagaita fruits cultivated in Goiânia, state of Goiás, in 2013 and 2014 harvests. The study was carried out with fruits produced by cagaita trees cultivated in the field of the School of Agronomy, Federal University of Goiás (EA/UFG), Goiânia, GO, where, in 1998, 440 cagaita seedlings from different municipalities in Goiás were planted. Fruits were collected from plants with 16 years of age in full production stage. Cagaita seeds show in their fatty acid profile mostly linoleic acid, oleic acid and palmitic acid. There was no variation in fatty acids content present in seeds between years 2013 and 2014, assuming that there are no external influences such as weather, foliar nutrients or soil, in the production of these oils
The dynamics of the production of AIDS-related stigma among pregnant women living with HIV/AIDS in Rio de Janeiro, Brazil
Authors: Monteiro Simone , Villela Wilza , Fraga Livia , Soares Priscilla , Pinho Adriana
Published: December 2016

The study analyses the relationship between AIDS-related stigma and the processes of discrimination prior to diagnosis among pregnant women living with HIV/AIDS. The fieldwork involved interviews about the life trajectories of 29 pregnant women living with HIV/AIDS, recruited at two AIDS services in Rio de Janeiro, Brazil. The analysis revealed that before HIV diagnosis, social and gender inequalities experienced by these women reduced their access to material and symbolic goods that could have enhanced educational and career prospects and their ability and autonomy to exercise sexual and reproductive rights. Being diagnosed with HIV triggered fear of moral judgment and of breakdown in social and family support networks. Given these fears, pregnant women living with HIV/AIDS opt for concealment of the diagnosis. It is necessary for health services, NGOs and government agencies to work together to face the factors that fuel stigma, such as socioeconomic and gender inequalities, taboos and prejudices related to sexuality, and also develop actions to enable women to redefine the meaning of the disease.
Avaliação do Serviço de Atendimento Móvel de Urgência em Santa Catarina, Brasil
Authors: Ortiga Angela Maria Blatt ,   Secretaria de Estado da Saúde de Santa Catarina,  Brazil, Lacerda Josimari Telino de , Natal Sonia , Calvo Maria Cristina Marino ,   Universidade Federal de Santa Catarina,  Brazil
Published: December 2016

Resumo: Estudo de caso para a avaliação do Serviço de Atendimento Móvel de Urgência (SAMU) em Santa Catarina, Brasil, período de 2013/2014. O modelo teórico lógico e a matriz avaliativa de julgamento foram validados em oficinas de consenso com especialistas. Foram propostas duas dimensões: gestão da urgência e atenção à urgência, analisadas por meio de 22 indicadores. Para coletar os dados, utilizaram-se entrevistas, observação direta nas oito centrais regionais de regulação do SAMU e questionário enviado aos coordenadores do SAMU municipal. A análise e a emissão de juízo de valor, segundo dimensão, subdimensão e indicadores separadamente, possibilitaram a identificação de potencialidades e fragilidades passíveis de intervenção. Nenhuma regional teve bom desempenho nas duas dimensões; todas foram classificadas como "regular" na atenção e metade, como "ruim" na gestão da urgência. Como potencialidade, destaque para comunicação ágil com o solicitante, padronização e suporte externo do atendimento. Os mecanismos de articulação e comunicação interna e externa necessitam de efetivação. É preocupante a qualidade das unidades de suporte avançado.
Flask sealing on in vitro seed germination and morphogenesis of two types of ornamental pepper explants
Authors: Batista Diego Silva , Dias Leonardo Lucas Carnevalli , Rêgo Mailson Monteiro do , Saldanha Cleber Witt , Otoni Wagner Campos
Published: December 2016

ABSTRACT: The influence of flask sealing and explant source on the in vitro morphogenesis of pepper, were evaluated in Capsicum annuum. Seeds were sterilized and inoculated in Murashige and Skoog media supplemented with vitamins, myo-inositol, sucrose, and agar. Gas exchange was evaluated in the germination stage by comparing 3 flask-sealing systems: rigid polypropylene lids (PLs) without vents, PLs with 1 vent, and PLs with 2 vents covered with membranes. In the regeneration stage, cotyledon and hypocotyl segments were transferred to the organogenesis-inducing media, being the different sealing types also tested in a factorial scheme. Photosynthetic pigments, morphological and hystological analyses were conducted for each treatment. Plants maintained in glass flasks capped with vented lids showed more vigorous growth and differentiated anatomical structures. These treatments resulted in taller plants, higher numbers and more expanded leaves, higher fresh and dry weights, and an increase in photosynthetic pigments. Cultivation of C. annuum in flasks with reduced gas exchange was more effective on callus induction. During the regeneration stage, hypocotyls were more effective than cotyledons. Sealing type influenced the morphogenic responses of pepper, demonstrating that an increase in gas exchange has a positive effect on biomass production and acclimatization of the plantlets.
Seasonality on the antifungal potential of green propolis collected in Campo Grande - MS, Brazil
Authors: Martini Daiane , Barbosa Giselle Feliciani , Matias Rosemary , Marques Filho Wolff Camargo , Garcia Nayara Zielasko Trombini
Published: December 2016

ABSTRACT: Apis melífera L. propolis is a resinous and balsamic material whose biological effects are related to its chemical composition. This chemical composition is greatly influenced by seasonality, so propolis from different seasons and regions has a different chemical composition. The increasing need for natural options to control fungi that cause damage to food crops makes propolis an alternative that deserves more research. In this context, the aim of this study was to evaluate the effect of seasonality on the antifungal potential of propolis collected in Campo Grande, Mato Grosso do Sul, Brazil, on the fungus Lasiodiplodia theobromae . Effects of different concentrations of ethanolic extracts of green propolis on the mycelial growth of the pathogen were evaluated. Concentrations of flavonoids and phenolic compounds in the samples were also determined by spectrophotometric methods. Results showed that the propolis extracts have a different chemical composition, potential fungi static effects on the tested fungus, and that there is interference of seasonality on the mycelial growth of the fungus, pointing to the concentration of 1250µg 100mL-1of the samples collected in the summer, in a first moment, as the most efficient.
Financial indicators to evaluate the economic performance of feedlot steers with different slaughter weights
Authors: Fabricio Edom de Avila , Pacheco Paulo Santana , Vaz Fabiano Nunes , Lemes Daniel Batista , Camera Angelina , Machado Gabriella Ibarra Ocaña
Published: December 2016

ABSTRACT: The objective of this study was to evaluate various financial indicators, estimated deterministically (considering historical quotes twelve consecutive years - 2003 to 2014), on the economic feasibility of finishing steers commercialized with different weights, using the simulation technique. Performance data steers were simulated with average initial weight of 350kg, fed in feedlot and slaughtered with 410, 440, 470, 500, 530, 560 and 590kg. The feeding period varies from 46 to 185 days, respectively. Based in various economic indicators, the viability of the investment decreased linearly according to the increase in slaughter weight. The coefficient of simple linear regression and means from lowest to highest slaughter weight were, respectively: net present value (-0.538 and R$ 67.37, R$ 65.28, R$ 32.14, R$ -7.34, R$ 8.01, R$ -12.38, R$ -23.41); index benefit: cost (-0.0003 and R$ 1.042, R$ 1.039, R$ 1.014, R$ 1.006, R$ 1.003, R$ 0.995, R$ 0.991); additional return on investment (-0.009 and 1.38, 1.29, 0.35, 0.11, 0.05, -0.08, -0.13% per month); internal rate of return (-0.009 and 2.21, 2.10, 1.28, 0.80, 0.93, 0.78, 0.73% per month). Feedlot use as termination option to obtain the direct benefits of this technology is an alternative investment with low economic return.
Depression Anxiety and Stress Scale (DASS-21) - Short Form: Adaptação e Validação para Adolescentes Brasileiros
Authors: Patias Naiana Dapieve , Machado Wagner De Lara , Bandeira Denise Ruschel , Dell'Aglio Débora Dalbosco
Published: December 2016

Resumo Este estudo teve como objetivo adaptar e validar a Depression Anxiety and Stress Scale (DASS-21) - Short Form para adolescentes brasileiros. Participaram do estudo 426 adolescentes de 12 a 18 anos (M = 14,91; DP = 1,66), sendo 264 meninas (62%) e 162 meninos (39%), de escolas públicas da cidade de Porto Alegre-RS, que responderam a uma versão adaptada, nomeada Escala de Depressão, Ansiedade e Estresse para Adolescentes (EDAE-A). As subescalas demonstraram níveis adequados de consistência interna, variando entre 0,83 e 0,90. A análise fatorial confirmatória indicou que o melhor modelo foi o de três fatores, confirmando o modelo original com as dimensões depressão, ansiedade e estresse. No escore total e por fatores, houve diferença por sexo, com maior média entre as meninas em todos os escores. Conclui-se que a EDAE-A apresenta qualidades psicométricas favoráveis, mostrando-se um simples e adequado instrumento de levantamento de sintomas de depressão, ansiedade e estresse para adolescentes brasileiros.
Escala de Resistência à Mudança (RAM): Construção, Evidências Psicométricas e Versão Reduzida
Authors: Vincenzi Silvana Ligia , Mendes Luís Augusto de Carvalho , Gouveia Valdiney Veloso , Andrade Dalton Francisco de
Published: December 2016

Resumo O presente estudo teve o objetivo de construir uma Escala de Resistência à Mudança (RAM) que conseguisse agrupar a base teórica existente sobre o tema, reunindo evidências de sua validade fatorial e consistência interna no contexto brasileiro, assim como analisar a adequação da versão reduzida da medida. Foram executados dois estudos. O primeiro contou com a participação de 338 empregados, em sua maioria, de empresas privadas (83%). Estes responderam à RAM e a uma qualificação demográfica. Uma análise de eixos principais (PAF) revelou a preponderância de um fator, explicando 25,56% da variância total e consistência interna (alfa de Cronbach, α) de 0,94. No Estudo 2, participaram 472 empregados, a maioria de empresas privadas (55%). Eles responderam à RAM-20 e a questões demográficas. Os resultados confirmaram a adequação psicométrica do instrumento, podendo ser empregada como uma medida unidimensional para avaliar a resistência à mudança em ambientes organizacionais.
Análise da Estrutura Interna do Psicodiagnóstico Miocinético - PMK
Authors: Silva Eni Ribeiro da , Rueda Fabián J. M.
Published: December 2016

Resumo O objetivo do trabalho foi investigar a estrutura interna do Psicodiagnóstico Miocinético por meio da análise fatorial exploratória. A amostra foi composta por 300 sujeitos, de 18 a 61 anos, ambos sexos, residentes em Minas Gerais. Foram utilizadas as seis folhas do teste e a aplicação ocorreu em uma única sessão. A correção foi realizada com a régua, por avaliadores com experiência na utilização e ensino do instrumento. Os resultados mostraram a existência de sete fatores, dos quais apenas três foram similares à estrutura original do teste. Os coeficientes alfa variaram de 0,57 a 0,92. Os traçados da dimensão Emotividade não se agruparam em um único fator. Os itens referentes aos "zigs" e "paralelas" se separaram nos fatores Dimensão Tensional e Predomínio Tensional. A estrutura original do teste não foi confirmada. São discutidas as fragilidades estruturais e das bases teóricas do PMK.
Memória de Reconhecimento: Modelos de Processamento Simples versus Duplo
Authors: Jaeger Antônio
Published: December 2016

Resumo O processo de reconhecimento de memórias consiste em discriminar informações previamente encontradas de informações novas. Duas abordagens teóricas divergentes buscam explicar esse fenômeno. A primeira propõe que o reconhecimento se baseia essencialmente na sensação de familiaridade gerada por cada estímulo. A segunda propõe que além da intensidade da familiaridade, a evocação de aspectos qualitativos e contextuais dos eventos memorizados possui um papel fundamental no processo de reconhecimento. Aspectos teóricos e metodológicos inerentes às duas linhas teóricas são criticamente discutidos no presente artigo, sendo que o resultado dessa discussão se apresenta favorável à segunda perspectiva teórica.
Neuropsicologia do Transtorno de Déficit de Atenção/Hiperatividade: Modelos Neuropsicológicos e Resultados de Estudos Empíricos
Authors: Wagner Flávia , Rohde Luis Augusto de , Trentini Clarissa Marceli
Published: December 2016

Resumo Diferentes modelos teóricos foram propostos para explicar os déficits neuropsicológicos e seu impacto no comportamento de indivíduos com Transtorno de Déficit de Atenção/Hiperatividade (TDAH). Os objetivos deste artigo serão apresentar os principais modelos neuropsicológicos do TDAH e possibilitar uma atualização acerca dos principais achados relacionados ao funcionamento neuropsicológico de pacientes com esse diagnóstico. Revisões e meta-análises sobre funcionamento executivo, aversão à resposta tardia, processamento temporal e variações intraindividuais no tempo de reação são apresentadas. O perfil neuropsicológico de pacientes com TDAH é heterogêneo e testes neuropsicológicos não são suficientemente sensíveis e específicos para realização do diagnóstico, embora sejam muito importantes na identificação do perfil cognitivo para estabelecimento de um plano de tratamento mais abrangente e adequado às necessidades especificas de cada paciente.