bluuebunny/crossref_metadata_2025 huggingface dataset:
Treatment of unilateral L5–S1 locked facet in a pediatric patient
Authors: Bhenderu Lokeshwar Sai Santosh , Lyon Kristopher A. , Richardson William Trent , Desai Ronak , Kriel Hilda H. , Rahm Mark D.
Published: April 2023

Background:

Traumatic unilateral lumbosacral facet dislocations are rare injuries. The majority of cases are treated with open reduction and instrumented spinal fusions. Only less commonly can they be managed conservatively.

Case Description:

A 7-year-old unrestrained passenger was involved in a high-speed motor vehicle accident. X-ray/magnetic resonance/computed tomography imaging documented a unilateral L5–S1 facet dislocation and multiple lumbar/sacral fractures. The patient underwent open reduction and temporary L5-pelvic instrumentation without fusion; the instrumentation was removed 10 weeks later at which point follow-up imaging showed preserved lumbosacral stability.

Conclusion:

Open reduction with temporary instrumentation without fusion was successfully utilized to treat a unilateral L5–S1 facet dislocation in a 7-year-old child.
Neurosurgical aspects and clinical outcomes on the treatment of Cushing disease in pediatric patients: Case series and literature review
Authors: Castillo-Huerta Nicole M. , Carassa de la Cruz Joanna I. , Quispe-Garate Luz , Lévano-Martínez María A. , Cabrera Bianca Miranda , Sheen Erick Custodio
Published: April 2023

Background:

Cushing disease (CD) is a state of hypercortisolism caused by an adrenocorticotropic hormone-(ACTH) producing pituitary adenoma which rarely occurs in pediatric patients. The outstanding features are weight gain and growth retardation. However, the insidious onset and rarity of the disease in children and adolescents often result in delayed diagnosis.

Case Description:

We present five patients <14 years of age who underwent neurosurgical treatment for CD at the Department of Neurosurgery of a public referral hospital in Lima, Peru. Age at diagnosis ranged from 5.5 to 12.5 years with a history of disease from 9 months to 3.5 years of moderate to severe stunting and obesity, among other features of Cushing syndrome (CS). Although biochemical tests and cerebral imaging were crucial for the diagnosis, confirmation was made by bilateral petrosal sinuous sampling. Regarding treatment, three patients underwent transcranial surgery, one patient underwent endoscopic transsphenoidal surgery, and one patient underwent microscopic transsphenoidal surgery. None of the patients underwent radiotherapy or pharmacological treatment. Only one patient had a recurrence and achieved remission until an endoscopic transsphenoidal approach was performed. Short- and long-term endocrinologic follow-up is also described in detail.

Conclusion:

CD is a heterogeneous disorder that requires multidisciplinary diagnosis and management. Transsphenoidal selective adenomectomy is the optimal treatment because of its higher remission rates. However, technical and anatomic aspects should be considered in pediatric patients.
Management of hangman’s fractures using anchored anterior cervical cages
Authors: Cho Steve S. , Farber S. Harrison , Kiernan Hayley , Teng Clare W. , Wanebo Oliver R. , Ponce Francisco A. , Tumialán Luis M. , Wanebo John E.
Published: April 2023

Background:

Hangman’s fractures comprise approximately 20% of C2 fractures and often require surgery to correct significant angulation and/or subluxation. Recently, anchored anterior cervical cages (ACCs) have been used to fuse C2-3 as they reduce the risks of soft-tissue dissection, bone drilling, operative time, and postoperative dysphagia.

Methods:

This single-center and retrospective study (2012–2019) included 12 patients (3 type I, 6 type II, and 3 type IIa fractures) undergoing C2-3 ACCs (zero profile, half plate, full plate). Preoperative and postoperative radiographic and clinical data were analyzed.

Results:

The 12 patients demonstrated the following findings: a mean operative time of 106 ± 21 min, blood loss averaging 67 ± 58 mL, and mean length of stay of 9.8 ± 7.7 days (6.4 ± 5.5 days in intensive care). The mean differences in preoperative versus postoperative radiographs showed an increase in disc angle (9.0° ± 9.4° vs. 14.0° ± 7.2°), reduction of subluxation (18.5% ± 13.6% vs. 2.6% ± 6.2%), and maintenance of C2-7 lordosis (14.3° ± 9.5° vs. 14.4° ± 9.5°). All patients demonstrated fusion on dynamic films obtained >6 months postoperatively. In addition, only one patient had Grade 0 subsidence, three had transient postoperative dysphagia, whereas none had either intraoperative complications or 90-day readmissions.

Conclusion:

ACCs proved to be a viable alternative to traditional anterior cervical discectomy/fusion to treat 12 patients with C2-3 hangman’s fractures in this preliminary study.
Mykola Pirogov’s (1810-1881) illness mystery. Computed tomography and 3D reconstruction of the head of the famous surgeon's mummy
Authors: Polishchuk Mykola Y. , Melnyk Oleg P. , Shevchuk Ivan V. , Robak Oleg P.
Published: April 2023

Introduction. It is known that at the age of 70, the outstanding surgeon Mykola Pirogov suffered from pain and a wound of the palate on the right and had problems with eating. He was consulted by well-known doctors M.V. Sklifosovskyi, E. von Wahl, V.F. Grube, E.I. Bohdanovskyi and the famous surgeon T. Billroth, convincing him that the ulcer was benign.On the fourth day after his death, on the initiative of his wife Baroness O.A. von Bistrom, Pirogov's body was embalmed by permission of the church.Case report. In 2018, M.I. Pirogov's body was re-embalmed in Vinnytsia according to the original method by scientists of Vinnytsia National Medical University and the National University of Life and Environmental Sciences of Ukraine.The remains were examined using a 32-slice computer tomograph Siemens "Somatom go. Up" (Germany) with 3D reconstruction of the entire body and the head of great surgeon. According to the protocol, the slices thickness was 0.8 mm, the voltage was 110‒120 kV, the current strength was 30‒230 mA, the thickness of reconstructions was 0.8 to 3.0 mm.Modern technologies made it possible to see destructive changes in the bones of the skull and establish the cause of Mykola Pirogov's illness and death. The 3D reconstructions prove the fact that Pirogov's diagnosis was correct. The existing bone changes indicate widespread malignancy, most likely cancer in the mouth, nasopharynx, and pterygopalatine fossa on the right.Discussion. Natural and anthropogenic mummies are important for history and science, as they can tell us about the health conditions and lifestyle of people in the past.Computed tomography is a non-destructive technique, and is therefore considered the gold standard for studying mummies. This method is also used during the embalming procedure and monitor the degree of preservation of the mummified body. Currently, computed tomography is widely used in mummy research to non-invasively assess the natural or anthropogenic origin, mummification embalming technique, bone and soft tissue preservation parameters, age, constitution, health status, cause of death, post-mortem injuries, etc.Conclusions. The use of computed tomography followed by 3D reconstruction is highly likely to not only predict the future, but also shed light on the mysteries of the past.
Соотношение семантики (типология семантики) производных основ, образованных аффиксами -hыт и -ааччы в якутском языке
Authors: ЯДРИХИНСКАЯ С.И. , ФИЛИППОВ Г.Г.
Published: April 2023

Affixal word formation and term formation is one of the relevant areas being developed in Yakut linguistics. Starting with the fundamental work by Otto von Bohtlingk “On the Yakut language”, a study of the Yakut word-formation system was conducted in the grammatical works of V.V. Radlov, S.V. Yastremsky, N.N. Poppe, A.E. Kulakovsky, A.A. Ivanov-Kyund, P.A. Oyunsky, N.S. Grigoriev, L.N. Kharitonov, N.K. Antonova, E.I. Ubryatova, P.A. Sleptsova, E.I. Okoneshnikova, V.I. Bygova, I.B. Ivanova, etc. Affix –hyt in the Yakut language is a fairly used word-formation form, which denotes a person or figure for whom this subject (concept) represents the object of their occupation or profession, or constitutes their special inclination, skill, dexterity, predilection. The affix –aachchi in the Yakut language is also a living productive participial-nominal affix, which: firstly, denotes an actor or an actor; secondly, it functions as a participle and a finite verb form that has the meaning of a commonly performed action. The first affix forms nouns from nominal bases, and the second affix forms nouns from verbal bases. These derived bases, when formed from an unambiguous basis, express nouns denoting an actor or figure, which are close-valued and synonymous. For example, suruksut from suruk ‘letter’ – ‘able to write, scribe, clerk’; suruyaachchy from suruy ‘write’ – ‘able to write usually, writer’: tyylbaaschyt from tylbaas ‘translation’ – ‘translator’: tylbaastaachchy from tylbaastaa ‘translate, translate’ –‘translator. This article is devoted to the analysis of the nature of this phenomenon, i.e., the synonymy of names formed by affixes on –hyt and –aachchy from verbs and verbal names ascending to the same verb-nominal derivative root basis. As a result of the study, it was revealed that the main difference between words formed by the affix –hyt from names and the affix –aachchy from these nameless verbs is that names with the affix -hyt express the subject of action from the professional side (skillful possession of quality, activity, ability, inclination, etc.), i.e. the object of which is the given object, and the names with the affix -aachchy call (show) the names simply as subjects of this (given) action.
ANTIMONOPOLY REGULATION OF DIGITAL MARKETS IN RUSSIAN FEDERATION
Authors: Пыженкова Е.С.
Published: April 2023

В статье анализируется роль цифровых платформ в экономике и последствия роста их рыночной власти. Делается вывод о необходимости адаптации российского антимонопольного законодательства к потребностям цифровой экономики и рассматриваются основные направления его совершенствования.

We analyze the role of digital platforms in the economy and the consequences of their growing market power. We make a conclusion about the necessity to adopt Russian antimonopoly legislation to the needs of digital economy and consider the main directions of its improvement.
PROBLEM SOLUTION ON MOVABLE GRIDS IN ANSYS FLUENT
Authors: Евсеев Д.Ю. , Овчинникова О.К.
Published: April 2023

Рассматриваются возможности использования универсального программного комплекса Аnsys Fluent для моделирования движения твердых тел под воздействием газодинамических сил. Даны примеры, реализующие возможные при решении таких задач подходы для моделирования вращательного и поступательного движения твердого тела.

The possibilities of using the universal software package AnsysFluent for modeling the motion of solids under the influence of gas-dynamic forces are considered. We provide examples illustrating the use of approaches to modeling the rotational and translational motion of a solid body to solve the problems in question.
RADAR LANDING SYSTEM
Authors: Синицын В.А. , Мясников С.А. , Синицын Е.А.
Published: April 2023

Предлагается техническое решение по построению новой радиолокационной системы посадки, обеспечивающей управление полетами и посадкой воздушных судов (ВС) различного назначения на аэродромах государственной и экспериментальной авиации.

We present a technical solution for the construction of a new radar landing system that provides flight control and landing of aircraft for various purposes at airfields of state and experimental aviation.
Antibacterial Nanomaterials for Dental Implants: From Coatings to Surface Modifications
Authors: Mateti Tarun , Tummala Venkat , T G Aditya , K Likhith , Thakur Goutam , Ramakrishna Seeram , Laha Anindita
Published: April 2023

Purpose: Nanomaterials have a plethora of applications in the field of dental sciences. Due to their peculiar properties and distinguishing characteristics, nanomaterials are used as candidates for coating titanium, acrylic, and PLA/PCL-based dental implants. This article reviews various nanomaterials that can impart antibacterial properties and be used as implant coating materials. Methods: Research articles published between 1992 and 2021, based on nanomaterial coatings for dental applications, were retrieved from Google Scholar and were thoroughly studied. Results: The research articles reviewed indicated that a substantial amount of progress had been made in the area of antibacterial resistance of nanomaterial-based coatings for dental implants. This work’s main contribution lies in a comprehensive review of the various nanostructures that inhibit the nurturing of bacterial biofilms on implants, thus diminishing the probability of any infection. Significance: Given the reported results, additional clinical research and investigation on nanostructure-coated implants aids in efficient implementation.
Substrate driven Spin Crossover in a Fe(II) scorpionate complex.
Authors: Pénicaud Margaux , Martinez Edoardo , Serrano Giulia , Cortigiani Brunetto , Squillantini Lorenzo , González-Estefan Juan , Velez-Fort Emilio , Duttine Mathieu , Gonidec Mathieu , Rosa Patrick , Mannini Matteo , Poggini Lorenzo
Published: April 2023

A new spin crossover complex based on a heteroscorpionate ligand was synthesized and characterized. Thin films were grown by sublimation in ultra-high vacuum on highly oriented pyrolytic graphite (HOPG) and on gold single crystal Au (111), and spectroscopically characterized through X-ray absorption and by X-ray photoemission. Temperature-dependent experiments on sub-nanometric deposits demonstrated that the thermally induced spin-crossover is preserved at a sub-monolayer (0.7 ML) coverage on HOPG, while deposits with similar thickness lose the switching behaviour on Au(111) surface. The system was unresponsive to light stimuli at low temperature indepently of the used substrate.
Photoactive yellow protein adsorption at hydrated polyethyleneimine and poly-L-glutamic acid interfaces
Authors: Krekic Szilvia , Mero Mark , Kuhl Michel , Balasubramanian Kannan , Der Andras , Heiner Zsuzsanna
Published: April 2023

Chiral and achiral vibrational sum-frequency generation (VSFG) spectroscopy was performed in the 1400-1700 and 2800-3800 cm-1 range to study the interfacial structure of photoactive yellow protein (PYP) adsorbed on polyethyleneimine (PEI) and poly-L-glutamic acid (PGA) surfaces. Nanometer-thick polyelectrolyte layers served as the substrate for PYP adsorption, with 6.5-pair layers providing the most homogeneous surfaces. When the topmost material was PGA, it acquired a random coil structure with a small number of ß2-fibrils. Upon adsorption on oppositely charged surfaces, PYP yielded similar achiral spectra. However, the VSFG signal intensity increased for PGA surfaces with a concomitant redshift of the chiral C-H and N-H stretching bands suggesting increased adsorption for PGA compared to PEI. At low wavenumbers, both the backbone and the side chains of PYP induced drastic changes to all measured chiral and achiral VSFG spectra. Decreasing ambient humidity led to the loss of tertiary structure with a re-orientation of a-helixes, evidenced by a strongly blue-shifted chiral amide I band of the ß-sheet structure with a shoulder at 1654 cm-1. Our observations indicate that chiral VSFG spectroscopy is not only capable of determining the main type of secondary structure of PYP, i.e., ß-scaffold, but is also sensitive to tertiary protein structure.
Assessment of the Factors of Acute Cognitive Fatigue of Virtual Organization Employees
Authors:   Leonov Moscow Region University of Technology, Spitsyna K. R.
Published: April 2023

The article presents the results of the empirical study of the factors of acute cognitive fatigue of virtual organization employees in the course of its activity. The indices “subjective fatigue feeling” when performing activity and “acute cognitive fatigue index” after performing the task have been assessed. The study has confirmed that a high level of subjective fatigue feeling corresponds to a high level of acute cognitive fatigue index. The study has found that gender, age, and expertise field are significant intergroup factors that help to differentiate the indices under assessment. The factor of subjective assessment of task complexity determines maximum difference of the indices in the group. The analysis of the results helps to define the perspectives for research of optimal functional state of a person in his or her field of expertise in subjective and information class.
İnsan İmmün Yetmezlik Virüsü (HIV) ile enfekte çocuklarda beslenme
Authors: AFACAN Fatma Öznur , ELİUZ TİPİCİ Beyza , DEMİREL Birsen
Published: April 2023

Edinsel immün yetmezlik sendromu, insan immün yetmezlik virüsünün neden olduğu bağışıklık sistemini zayıflatan bir enfeksiyon hastalığıdır. Günümüzde insan immün yetmezlik virüsü ve edinsel immün yetmezlik sendromu çocuklar için önemli bir halk sağlığı sorunu olmaya devam etmektedir. Birleşmiş Milletler İnsan immün yetmezlik virüsü / Edinsel immün yetmezlik sendromu Ortak Programı 2020 yılı raporlarına göre, insan immün yetmezlik virüsü ile yaşayan çocukların yaklaşık yarısı antiretroviral tedavi alabilmekte ve pediatrik insan immün yetmezlik virüsü enfeksiyonunun tedavisi, kaynakları kısıtlı olan ülkelerde zorlu olmaya devam etmektedir. İnsan immün yetmezlik virüsü ile yaşayan çocuklarda anormal vücut yağ dağılımı, insülin direnci, kemik yoğunluğunda azalma ve lipodistrofi sendromu gibi komplikasyonlar görülebilmektedir. Malnütrisyon ise, hastalığın progresif ilerlemesinde hızlandırıcı bir etkendir ve erken ölüm riskinin artmasına, yaşam kalitesinin düşmesine neden olmaktadır. Dünya Sağlık Örgütü, insan immün yetmezlik virüsü ile yaşayan çocuklarda beslenme değerlendirmesi ve desteğinin önemli olduğunu bildirmektedir. Bununla beraber Beslenme ve Diyetetik Akademisi, tıbbi beslenme tedavisinin bu popülasyon için rutin bakıma entegrasyonunu desteklemekte ve insan immün yetmezlik virüsü ile yaşayan çocukları hedef alan bireyselleştirilmiş tıbbi beslenme tedavisini önermektedir. Bu derlemede insan immün yetmezlik virüsü ve edinsel immün yetmezlik sendromu ile yaşayan çocuklarda beslenme ile ilişkili klinik sorunlar, antiretroviral tedavinin yan etkileri ve tıbbi beslenme tedavisi hakkında güncel yaklaşımlar incelenmiştir.
Research of cross-cultural management of business activities in European markets
Authors: Yevtushenko V. , Lisenyi E. , Lin Vu Zieu
Published: April 2023

Globalization of business, promotion of economic interests to the markets of other countries, processes of unification and creation of common economic space require knowledge of national customs and national culture. Culture is, first of all, predictability. The ability to understand and use the features of national cultures, interpersonal communications and business ethics in global business is an important task of cross-cultural management. The success of international companies in Europe in providing high quality products and services depends, on the one hand, on the dynamics of the growing economic environment and, on the other hand, on the adoption of global quality standards and procedures. As the European market becomes more and more global, the products and services offered by international companies around the world face the challenges of a multicultural environment, not only at the level of customer relations, but also deep inside the companies, at the level of employees. The article describes the characteristics of cross-cultural management of enterprises in the European markets, identifies the barriers to its implementation, and considers the most effective solutions in the field of cross-cultural personnel management. Cross-cultural management of enterprises in the European markets is, first of all, the creation and application of technologies for managing cultural diversity in the context of globalization, which successfully operate in different cultures, prevention of intercultural conflicts. As a solution, the development of intercultural competencies, training of global managers in Europe in key aspects of intercultural interaction, introduction and active use of advanced digital technologies, as well as building a management system are proposed. Knowledge management provides the necessary technological support for cross-cultural management of European enterprises to improve knowledge sharing, their effective use in the activities of multinational companies and international joint ventures in Europe.
The banking system of Ukraine during the period of marital status: challenges and achievements
Authors: Doroshenko N. , Baklanova A.
Published: April 2023

The article is devoted to the analysis of the banking system of Ukraine as of November 2022, namely for 9 months of a full-scale Russian invasion of the territory of an independent state - Ukraine. The war continues, now the terrorist country is targeting the energy and civilian structure of Ukraine. But the main state structures have come out of a state of shock, stabilized and are working in full mode. It should be noted that there are still very few studies on the chosen topic in the Ukrainian scientific community, and their need is growing every day, since practical actions should be based on theoretical grounds. The purpose of the article is to study the activities of the banking sector of Ukraine after the events of February 24, 2022 and to analyze the actions of the NBU, which currently keep the banking system indestructible. The article describes the main measures of the NBU as an organization that conducts monetary policy and keeps the monetary unit - the hryvnia in a balanced state. Actions that led to the stable operation of the banking system after a full-scale Russian invasion and ensure not only the controlled operation of banks, but also keep the information field for customers transparent and eliminates panic among the population. The main limitations for clients of commercial banks and the stages of stabilization of commercial banks are also analyzed. The study traced the dynamics of the dollar, rates on deposits and loans for the future, taking into account the results of the banking system in recent years. The actions of commercial banks regarding the introduction of loan repayment holidays were evaluated. It also proposed steps that will help in the future to carry out a stable banking policy and get closer to reducing the factors on which the country's economy as a whole depends (inflation index, interest rate, credit interest, foreign exchange rates against the dollar). The reasons for the closure of banks are analyzed and recommendations are made to save banking institutions that are on the verge of liquidation by providing subordinated debt by the state. Compared the decision of the National Bank of Ukraine and the Ministry of Finance of Ukraine, in terms of restrictions on the provision of loans and deposits, revealed negative aspects of the government's actions regarding the economic condition of the country. The dynamics of changes have been traced and conclusions have been drawn on the indicators of return on assets and equity over the years of the COVID-19 pandemic (2020 - 2021) and during the period of full-scale invasion of Ukraine.
Multifactor econometric models of the standard of living of the population
Authors: Danіch V. , Rusakova D.
Published: April 2023

The topic of the standard of living is one of the most relevant in the modern world, because everyone strives for development, improvement and comfort at different social levels, starting from ordinary workers and ending with the presidents of countries. Every country strives to create the highest quality conditions for a better life for its population. But the question arises as to which factors contribute to a better quality of life. Therefore, in the modern world, leading countries and countries with developed economies are trying to research in more detail and develop effective strategies for the development of people's well-being. This work covers the topic of happiness, well-being and the modern perception of the standard of living of the population. The problems of perception of these parameters and their assessment are considered. Socio-economic models were obtained, which are mathematical models of the dependence of the level of happiness on the set of available factors. Based on the data of the global rating of the happiness level of the countries The World Happiness Report, socio-economic models of the quality of life of the population were built and studied using the method of regression analysis of multifactor models, also such methods of building a multifactor model as the method of stepwise inclusion of factors, the method of stepwise exclusion of factors were additionally used and the ridge regression method. According to the results of the constructed models, the structure of the factors in the model and the level of their influence on the explained variable were investigated. The most important indicators, which have the highest frequency in explaining the dependent variable, are highlighted. The dependent variable in the function of the regression model is the happiness rating of the countries, the independent variables affecting this indicator are the following factors: GDP per capita, healthy life expectancy, social support, freedom to make life choices, generosity and perception of corruption. The main stages of the research will be carried out in a special package of Statistica application programs, additional auxiliary calculations will also be performed in Microsoft Excel.
Analysis of forms of implementation of the concept of social responsibility of business in the conditions of combat actions in Ukraine
Authors: Evtushenko A. , Tymohova H. , Kurilenko O.
Published: April 2023

By improving relations with the public, stakeholders, investors and authorities, corporate social responsibility has a significant impact on the ability of domestic and foreign companies to successfully develop and achieve economic competitiveness, as well as increase market share and create a positive image of the organization. By implementing various forms of social responsibility, the company realizes its contribution to the world of the future, solving local and global problems of humanity. Transparent two-way communication between enterprises becomes an effective tool that can significantly increase trust. The paper analyzes the forms of implementation of the concept of social responsibility of business in the conditions of hostilities in Ukraine. The results were obtained using the synthesis method, the official websites of the companies were analyzed, i.e. CSR sections, official pages of social networks (Facebook, Instagram), media publications, non-financial reports, CSR strategies, recommendations, policies and other publicly available documents. The study considered the influence of factors on decision-making by the company during the military operations in Ukraine according to the following criteria: adaptation of Ukrainian business, development of business strategies, official statement on the termination of cooperation with the Russian Federation. The impact of the total war of the Russian Federation against Ukraine on compliance/non-compliance with the policy of corporate social responsibility The considered features and results of using "Social Hub" and "impact investing" as a form of interaction between the enterprise and society. The implementation of the same form of KVS as "Social Hub" and "impact investing" provides not only financial support of the company for charitable purposes, but also contributes to the formation of a stable positive attitude among internal employees, thereby increasing the reputational capital of the business.
Quantitative morphological analysis of features of remodeling of the synovial membrane vasculature of the temporomandibular joint in hyperglycemia
Authors: Shulgai A.H. , Hnatiuk M.S. , Tatarchuk L.V. , Monastyrska N.Ya.
Published: April 2023

The vasulature of the synovial membrane of the temporomandibular joint of 18 laboratory mature Vietnamese mini male pigs divided into 3 groups was morphologically studied. Group 1 – 6 control experimental animals, 2 – 6 pigs with a 30-day’s experimental hyperglycemia, 3 – 6 pigs with a 60-day’s hyperglycemia. Hyperglycemia was induced by a single intraperitoneal injection of streptozotocin at a dose of 50 mg/kg. Pigs were sacrificed by bloodletting under general thiopental sodium anesthesia 30 and 60 days after the start of the experiment. On the indicated days of the experiment, the concentration of glucose in the blood was determined. On the micropreparations of the synovial membrane of the temporomandibular joint in the small caliber arteries there was measured the diameter of the vessel, the diameter of the lumen, the thickness of the muscular, adventitious membranes, the Wogenworth and Kernogan indices; in the veins – the diameter of the vessel, its lumen, and the thickness of the vein. In arterial and venous vessels, morphometry of endothelial cells, their nuclei, the volume of their damage, and nuclear-cytoplasmic indices were determined. Arterial, metabolic and venous vessels of the hemomicrocirculatory bed were studied morphometrically, their number per 1 mm² of the synovial membrane was determined. Quantitative values were processed statistically. In conditions of experimental hyperglycemia, a thickening of the synovial membrane of the arteries of the tempo­romandibular joint, a narrowing of their lumen, a decrease in the Kernogan index, an increase in the Wogenvoort index, the volume of damaged endotheliocytes, a disorder of their nuclear-cytoplasmic indices were revealed, an increase in the outer and inner diameters of the veins, the volume of damaged endotheliocytes, disorders of their nuclear-cytoplasmic indexes, plethora was noted. Structural changes in the hemomicrocirculatory bed in experimental hyperglycemia were characterized by a decrease of the diameters of arterioles, precapillary arterioles, hemocapillaries, dilation of capillary venules and venules, marked decrease of microvascular density. The most pronounced degree of remodeling of the studied structures was found in the vessels of the hemomicrocirculatory bed of the synovial membrane of the temporomandibular joint in a 60-day’s experimental hyperglycemia.
Application of the infrared thermography method in diagnosis of Raynaud`s phenomenon
Authors: Zabolotnyi D.I. , Loboda T.V. , Dunaievskyi V.I. , Kotovskyi V.Y. , Timofeiev V.I. , Nazarchuk S.S.
Published: April 2023

The development of modern diagnostic medicine, the important task of which is the use of non-invasive methods for detecting a disease without impact of radiation exposure, has led to the spread of the method of infrared thermography, which allows to quickly and informatively identify pathological conditions of a person within a single examination. The main complaints characteristic of Raynaud's phenomenon are associated with cold, hyperemia, edema, and a feeling of paresthesia in the limbs. A significant number of scientific works have been devoted to the study of the Raynaud's phenomenon, where basically, examples of manifestations of Raynaud's phenomenon are given in the form of a violation of the microcirculation of the distal parts of limbs. Comprehensive studies of the combination of Raynaud's phenomenon with concomitant diseases, according to the authors, are insufficiently covered. The application of sophisticated modern laboratory diagnostic methods to detect this disease is nonspecific and burdensome for the patient. Thermographic diagnostics within one examination reveals both the presence of signs of Raynaud's phenomenon and concomitant somatic diseases. This paper presents the results of many years’ thermographic research, demonstrating the variety of manifestations of the Raynaud's phenomenon. For the first time, it has been shown that patients with signs of Raynaud's phenomenon, as a rule, have concomitant somatic diseases, which should be the subject of research of specialists in different medical fields to determine the relationship of Raynaud's phenomenon with the identified diseases. The results of visualization of thermoasymmetries of the skin of various pathological conditions during a complex thermographic examination were obtained, which greatly simplify the diagnostic search and understanding the complexity and danger of Raynaud's phenomenon. Of particular importance are the results of work for the differential diagnosis of complications of diabetes mellitus – diabetic foot syndrome. The paper presents some results of thermographic examinations of patients with signs of Raynaud's phenomenon and identified pathological changes in the body.
Radioisotopic evaluation of reparative osteogenesis in various forms of osteomyelitis of the mandible
Authors: Komskyi M.P. , Romanenko Ye.G , Lisova I.G. , Titov G.I. , Trushenko O.S. , Lavreniuk Ya.V.
Published: April 2023

The aim of this work is the rationale for using radiological method of examination in diagnosing and monitoring the mandibular osteomyelitis treatment. A total of 60 patients with traumatic (first group) and odontogenic (second group) mandibular osteomyelitis were examined. Among them, there were 24 (40%) males and 36 (60%) females aged between 20 and 45 years. The patients received intravenous injection of Technefor (99MTc) with the radiation activity of 300-400 megabecquerel 3-4 hours before scintigraphy. The mandible radiopharmaceutical uptake was measured using a computerized gamma camera. The level of 99MTc accumulation in the bone tissue was quantified by gamma-radiation. A patient was examined on the day of hospital admission and on day 14 after surgical treatment of osteomyelitis of the mandible. Our studies have shown that all forms of traumatic and odontogenic osteomyelitis are accompanied by significant changes in 99MTc uptake in the mandible, however, both 99MTc uptake and its decrease after surgical treatment were most obvious in odontogenic osteomyelitis. The increase in 99MTc uptake in traumatic mandibular osteomyelitis was 38,1% (up to 1669,9 gamma-radiation pulses), 140,9% (up to 2913,7 gamma-radiation pulses) and 129% (up to 2772,7 gamma-radiation pulses) in the acute, subacute and chronic stages of the disease, respectively. The increase in 99MTc uptake in odontogenic mandibular osteomyelitis was 160,0% (up to 3144,1 gamma-radiation pulses), 218,1% (up to 3846,6 gamma-radiation pulses) and 275,2% (up to 4537,6 gamma-radiation pulses) in the acute, subacute and chronic stages of the disease, respectively. The increase in 99MTc uptake was due to blood flow enhancement, metabolic disorders, activation of osteoblast and osteoclasts in the bone tissue. The decrease in 99MTc uptake after the treatment indicated the positive response to treatment. Scintigraphic examination was more sensitive and specific in comparison to X-ray diagnostics of mandibular ostemyelitis. The sensitivity of scintigraphic findings ranged from 60.0% to 100%, and the specificity was 100% at different stages of ostemyelitis.
Medico-social conditions of educational activity, quality of life and aspects of psychophysiological adaptation of modern pupils and students: features of interrelation and their hygienic assessment
Authors: Tymoshchuk O.V. , Serheta I.V. , Malyshevska О.S. , Melnyk V.I. , Motriuk V.B.
Published: April 2023

The purpose of the study is a comprehensive hygienic assessment of the relationship between medico-social conditions of educational activities, quality of life and adaptive capabilities of students. During the research conducted on the basis of 5 modern educational institutions of different types: university, college, specialized school, lyceum and school, the significant deviations of indicators of hygienic assessment of daily regimen of pupils and students from generally accepted normative values (p<0.05-0.001)were revealed, which, first of all, concerned the excess of the maximum allowable duration of their daily stay in educational institutions, the length of time required to complete homework, low levels of physical activity, etc. It was found that the highest levels of quality of life among boys and girls are recorded according to the scales of Physical Functioning (PF), Bodily Pain (BP) and Role-Physical (RP), the lowest ones were Mental Health (MH), Vitality (VT) and Social Functioning (SF). The relationships between the values that indicate the characteristics of quality of life and features of the psychophysiological adaptation of pupils and students were revealed. Moreover, the largest number of relationships (r=0.36-0.77; p<0.05-0.001) which characterize quality of life indicators belong to boys according to the scales of Physical Functioning (PF), Mental Health (MH), Vitality (VT) , Bodily Pain (BP); to girls – Bodily Pain (BP), Vitality (VT), Mental Health (MH), General Health (GH), Role-Emotional (RE). When determining the features of intersystem relationships between components of quality of life and indicators of psychophysiological functions, it was found that the closest relationship (r=0.37-0.99; p<0.05-0.001) is observed between the characteristics of the speed of visual-motor reactions, mobility and balance of nervous processes, coordination of movements and indicators of quality of life according to the scales of General Health (GH), Physical Functioning (PF), Social Functioning (SF) and Mental Health (MH).
Features of distribution of titanium and silver in the internal organs of laboratory rats and mice exposed to high doses of titanium dioxide nanoparticles and its composite with nanosilver
Authors: Yavorovsky O.P. , Andrusyshyna I.М. , Riabovol V.M.
Published: April 2023

In Ukraine and worldwide more attention is paid to the study and application of titanium dioxide nanoparticles (TiO2 NPs). These nanoparticles find use in many industrics (medicine, cosmetology, materials science, environmental protection, etc.). The aim of the study was to study the features of the distribution of TiO2 nanoparticles, a composite of titanium nanodioxide with nanosilver (TiO2/Ag NPs) in the internal organs of laboratory animals (mice, rats) after acute intraperitoneal administration of TiO2 NPs and TiO2/Ag NPs. The objects of toxicological studies were TiO2 NPs (crystalline form - anatase, 21-28 nm in size) and TiO2/Ag NPs (17-22 nm in size, 4 wt% Ag) synthesized at the Frantsevich Institute for Problems of Materials Science NASU. Nanopowder suspensions were introduced in high doses (from 1,000 to 13,000 mg/kg) during a 14 days observation period. The content of che­mical elements Ti and Ag in organs (liver, kidneys, spleen, heart, lungs, adrenal glands, thymus, brain) was determined using the method of optical emission spectroscopy with inductively coupled plasma. It was found accumulation of metals in the internal organs on the 14th observation day after a single intraperitoneal injection. It was revealed that the kidneys and liver in rats are the most sensitive to the accumulation of TiO2 and TiO2/Ag NPs; accumulation in the thymus and adrenal glands is also shown. In an experiment on mice, it was found that the kidneys, liver and spleen accumulate titanium and silver after exposure at a dose of 4, 7 and 10 thousand mg/kg of NPs of TiO2 and TiO2/Ag.
Управління змінами в системі маркетинг-менеджменту діяльності вітчизняних суб’єктів господарювання відповідно до концепції «Індустрія 5.0»
Authors: Пащенко Ольга Петрівна , Тарасюк Олександр Вікторович
Published: April 2023

У статті обґрунтовано необхідність впровадження концепції «Індустрія 5.0». Ключовими аспектами цієї моделі є стійкість, сталий розвиток та людиноцентричність. Тобто важливим є прийняття рішень, які сприяють зростанню сталості та стійкості виробництва до змін у середовищі діяльності, зростанню рівня конкурентоспроможності у довгостроковій перспективі, враховуючи при цьому вплив цифрового робочого середовища на безпеку працівників, задоволеність умовами праці та роботою загалом, враховуючи інтереси інших зацікавлених сторін, зокрема споживачів.  Визначено її переваги та ефективність для вітчизняних суб’єктів господарювання, зокрема працівників. Основними перевагами впровадження зазначеної концепції для працівників є наступні: 1) зміна ролі працівника для галузі; 2) безпечність та інклюзивність робочого середовища; 3) навички, підвищення кваліфікації та перекваліфікація. Неможливо забезпечити підвищення кваліфікації кожного окремого працівника галузі. За умови підвищення автоматизації деякі навички застаріють, розвивати їх стане непотрібним. Важливо забезпечити певний базовий рівень знань і розуміння кожним працівником цифрових навичок, особливо це стосується розуміння штучного інтелекту, його потенційних переваг та обмежень. Щоб застосовувати технології, співробітники мають бути долучені до процесу, навчені та мотивовані. Загальна ефективність концепції, що розглядається, для промисловості загалом є довгостроковою – постійна конкурентоспроможність і актуальність завдяки успішній адаптації до мінливого світу та нових ринків, що може бути досягнуто завдяки: залученню та утриманню талантів, ефективність використання ресурсів для забезпечення відповідного рівня стійкості та конкурентоспроможності, підвищення рівня стійкості, тобто здатності гнучко справлятися зі змінами. Окреслено умови успішної реалізації концепції, зокрема тісна співпраця між підприємствами, освітніми та навчальними закладами. Освіта, підготовка кадрів, перекваліфікація та підвищення кваліфікації, є одними з найактуальніших питань, які необхідно вирішити при адаптації до цифрового переходу в галузях, оскільки кваліфікований людський капітал має надзвичайно важливе значення для втілення цього в реальність. Важливим є розуміння для суспільства того факту, що інновації створює не держава, уряд, а підприємці, молодь та інноваційно-підприємницькі університети. При цьому державні та фінансові установи мають сприяти та допомагати бізнесу, що реалізує та впроваджує інновації. Розроблено модель маркетинг-менеджменту підприємства відповідно до концепції «Індустрія 5.0)». Запропоновано в основу моделі покласти принципи людиноцентричності та цифровізації процесів менеджменту та маркетингу суб’єктів господарювання.
Особливості управління проєктом «Міжнародна академічна мобільність» Програми Еразмус+ в умовах війни
Authors: Полянська Анна Станіславівна
Published: April 2023

Академічна мобільність є одним із найкращих і найефективніших інструментів підвищення якості освіти та конкурентоспроможності серед ЗВО. Впродовж останніх 18 років, після приєднання до Болонського процесу в 2005 році і визнання мобільності як однієї з цілей на шляху до створення європейського простору вищої освіти, Україна виконує завдання з реформування національної системи освіти завдяки активній позиції в реалізації програм міжнародної академічної мобільності. У статті розкрито сутність та види академічної мобільності українських студентів, також розглянуто зміст та основні положення нормативно-правових документів, які регламентують здійснення академічної мобільності як однієї зі складових частин інтернаціоналізації вищої освіти. Завдяки Програмі Європейського Союзу Еразмус+, проєкту «Міжнародна кредитна мобільність» перед українськими здобувачами вищої освіти відкриті широкі можливості для здійснення ними академічних обмінів, що є важливим кроком у процесі імплементації Закону України «Про вищу освіту» та створення дієвого інструментарію для інтернаціоналізації українських ЗВО. Здійснено короткий огляд загальних принципів реалізації проєкту «Міжнародна академічна мобільність» на базі Державного університету «Житомирська політехніка», проаналізовано сучасний стан міжнародної академічної мобільності в Україні в умовах війни.
Методичний підхід до оцінювання якості продукції
Authors: Світлишин Ігор Іванович
Published: April 2023

Поглиблення євроінтеграційних процесів зумовлює необхідність розроблення та запровадження у діяльність вітчизняних суб’єктів господарювання підходів і механізмів щодо підвищення їх конкурентоспроможності. Досвід успішних підприємств свідчить, що доцільним є впровадження в систему менеджменту суб’єктів господарювання підсистеми управління якістю. Реалізація цього завдання вимагає насамперед наявності відповідної теоретико-методичної бази, важливою складовою якої є питання визначення та оцінювання якості продукції. Результати вивчення наукових праць стосовно методичних підходів до оцінювання якості продукції свідчать про наявність досить широкого спектра позицій вчених, окремі серед яких потребують уточнення, інші – доповнення, а деякі – є дискусійними. Виходячи із сутності поняття «якість продукції», положень відповідних міжнародних та вітчизняних стандартів, результатів опрацювання позицій науковців, а також практичного досвіду, удосконалено методичний підхід до оцінювання якості продукції. Зокрема, включено до цієї процедури етап ідентифікації вимог до властивостей (власних характеристик) продукції, що забезпечує постійну актуалізацію останніх, а отже, дає змогу отримувати достовірні дані щодо фактично досягнутого рівня якості продукції. Крім того, методичний підхід побудовано на базі авторської розробки щодо кількісного визначення якості продукції, як зазначається у формулі 1, що забезпечує отримання точних і повних даних стосовно фактичного значення останньої, дає можливість виявляти причини та розробляти дієві заходи щодо поліпшення якості. Для оцінювання якості продукції запропоновано застосовувати не лише базові, а й цільові показники якості, що дає змогу визначати рівень результативності функціонування підприємства за цим критерієм. Вважаємо, що запропонований підхід забезпечить здійснення дієвого моніторингу, контролю та аналізування досягнутого рівня якості продукції, а отже, дасть змогу розробляти та запроваджувати у діяльність вітчизняних підприємств заходи щодо поліпшення якості, що сприятиме підвищенню їх конкурентоспроможності.
Теоретичні передумови розвитку бухгалтерського обліку в гірничодобувних підприємствах під впливом концепції сталого розвитку
Authors: Замула Ірина Валеріївна , Шавурська Олена В’ячеславівна
Published: April 2023

Проаналізовано чинники впливу на стан підприємств гірничодобувної галузі України. Встановлено, що видобувна промисловість має значний потенціал для розвитку, що підтверджується значними запасами природних ресурсів. Проте через екстенсивне природокористування спостерігається виснаження надр, що потребує реформування економічного механізму користування ними. Гірничодобувна галузь є конкурентоспроможною на міжнародну рівні, що підтверджується зростанням обсягів експортованої продукції за 2017–2021 роки. Однак, враховую чи інтеграційні прагнення України щодо вступу в ЄС, необхідним є імплементування міжнародних норм і стандартів для підвищення ефективності діяльності підприємств цієї галузі та зменшення їх негативного впливу на стан навколишнього природного середовища. Вирішення проблем, які мають місце у гірничодобувній галузі України, потребує комплексного підходу та впровадження екологічно безпечних технологій, екоінновації. Стратегію сталого розвитку гірничодобувної галузі доцільно розвивати за такими напрямами: економічний в частині конкурентоспроможності, екологічний, що враховує ресурсну ефективність та екобезпеку, а також соціальний, який передбачає зайнятість і створення безпечних умов праці. Ефективне управління природними ресурсами можливе тільки у випадку наявності достовірної та повної інформації про ці природні ресурси. Бухгалтерський облік є інформаційною системою, що надає внутрішнім користувачам інформацію для прийняття ефективних управлінських рішень, що спрямовані на експлуатацію та раціональне використання ресурсів. Виокремлено інструменти реалізації сталого природокористування: нормативно-правові, інформаційно-комунікаційні дослідження та розробки. З врахуванням специфіки діяльності гірничодобувної галузі уточнено об’єкти бухгалтерського обліку для подальшого удосконалення їх організаційно-методичного забезпечення.