Factors Associated With Coronary Angiography Performed Within 6 Months of Randomization to the Conservative Strategy in the ISCHEMIA Trial
Authors: Pracoń Radosław , Spertus John A. , Broderick Samuel , Bangalore Sripal , Rockhold Frank W. , Ruzyllo Witold , Demchenko Elena , Nageh Thuraia , Grossman Gabriel Blacher , Mavromatis Kreton , Manjunath Cholenahally N. , Smanio Paola E.P. , Stone Gregg W. , Mancini G.B. John , Boden William E. , Newman Jonathan D. , Reynolds Harmony R. , Hochman Judith S. , Maron David J. , Doan John , Linefsky Jason , Lee Raven , Patel Risha , Miller Todd , Yang Cho So , Milbrandt Susan , Shelstad Dawn , Banerjee Subhash , Kamath Preeti , Tejani Ishita , Cobos Stanley E. , Quiles Kirsten J. , Dwyer Raven R. , Donnino Robert M. , Espinosa Dalisa , Phillips Lawrence M. , Saric Muhamed , Abdul-Nour Khaled , Schley Allison , Golden Heather , Stone Peter H. , Osseni Hermine , Wiyarand Charlene , Douglass Peter , Pomeroy Hayley , Craft Alexandra , Harvey Bethany , Jang James J. , Anaya Olivia , Yee Gennie , Goold Phoebe , Weitz Steven , Giovannone Steven , Pritchard Lori , Arnold Suzanne , Gans Rosann , Henry O’Keefe, Jr James , Kennedy Paul , Shapiro Michael D. , Ganesan Shobana , Schlichting David , Naher Aynun , El-Hajjar Mohammad , Sidhu Mandeep S. , Fein Steven A. , Stewart Wendy L. , Torosoff Mikhail T. , Salmi Kristin M. , Lyubarova Radmila , Mookherjee Sulagna , Drzymalski Krzysztof , McFalls Edward O. , Garcia Santiago A. , Bertog Stefan C. , Johnson Debra K. , Siddiqui Rizwan A. , Herrmann Rebekah R. , Ishani Areef , Hansen Ronnell A. , Georges Khouri Michel , Arges Kristine , LeFevre Melissa , Tomfohr Jennifer , Goldberg Jonathan L. , Ann Byrne Kimberly , Zappernick Taissa , Goldweit Richard , Canada Sallie , Kakade Meghana , Mieses Patricia , Cobos Stanley E. , Dwyer Raven R. , Cohen Ronny A. , Espinosa Dalisa , Mirrer Brooks , Quiles Kirsten J. , Navarro Victor , Rantinella Magdalena , Rodriguez Jessica , Mancilla Olivia , Winchester David E. , Stinson Susan , Kronenberg Marvin , Weyand Terry , Rogal Philip , Crook Sherron C. , McFarren Christopher , Heitner John F. , Ho Jean , Khan Saadat , Mohamed Mahmoud , Dauber Ira M. , Soltau Mary R. , Rose Delsa K. , Wimmer Rebecca J. , Siegel Kathy E. , Derbyshire Susan , Cannan Charles , Dixon Michelle , Leonard Gerald , Sudarshan Sriram , Heard Ciarra , Gabriel Viviana , Desire Sukie , Mehta Puja K. , McDaniel Michael , Rashid Fauzia , Lerakis Stamatios , Asier Senait , Quyyumi Arshed , Patel Keyur , Wenger Nanette K. , Hedgepeth Chester M. , Gillis Jennifer , Hurlburt Heather , Manocchia Megan , Rosen Alan , Moore Susan , Congdon Elizabeth , Sahul Zakir , Brandt Gail , Marchelletta Nora , Wippler Kristina , Booth David , Taul Yvonne , Leung Steve , Isaacs Jennifer , Abdel-Latif Ahmed , Bulkley Viktoria , Reda Hassan , Rodgers Caroline , Ziada Khaled , Setty Sampoornima , Halverson Kimberly E. , Roraff Christine , Thorsen Jonean , Barua Rajat S. , Ojajuni Amarachi , Olurinde Oni , Surineni Kamalakar , Hage Fadi , Valaiyapathi Badhma , Caldeira Christiano , Davies James E. , Leesar Massoud , Heo Jaekyeong , Iskandrian Amy , Al Solaiman Firas , Singh Satinder , Dajani Khaled , Kartje Carol M. , El-Hajjar Mohammad , Mesropian Paul Der , Sacco Joseph , Rawlins Michele , McCandless Brian , Thomson Jennifer , Orgera Marisa , Sidhu Mandeep S. , Colleen Rogge Mary , Arif Imran , Bunke Julie , Kerr Hanan , Unterbrink Kendra , Fannon Jacqueline , Burman Cynthia , Trejo Jorge F. , Dubin Marcia F. , Fletcher Gerald , Lane Gary E. , Neeson Lynn M. , Parikh Pragnesh P. , Pollak Peter M. , Shapiro Brian P. , Landolfo Kevin , Gemignani Anthony , Beaudry Sarah , O’Rourke Daniel , Meadows Judith L. , Tirado Stephanie A. , Halliday Janet , Julian Pamela , Call Jason T. , Lane Stephanie, M. , Stanford Jennifer L. , Hannan Joseph , Bojar Robert , Arsenault Patricia , Kumar Deepti , Sigel Pamela , Mukai John , Martin Edward T. , Brooks Miriam , Vorobiof Gabriel , Douangvila Ladda , Gevorgyan Rubine , Moorman Alec , Ranjbaran Fatima , Smith Bryn , Ohmart Carly , Kinlay Scott , Hamburger Robert J. , Rocco Thomas P. , Ly Samantha , Bhatt Deepak L. , Quinn Margot C. , Croce Kevin , Temiyasathit Sara , Quin Jacquelyn A , Do Jacquelyn , Anumpa Jati , Tobin Desiree , Zenati Marco , Faxon David P , Rayos Glenn , Langdon Jennifer , Werner Bayer Marcia , Seedhom Ashraf , O’Malley Amanda , Sullenberger Lance , Orvis Erin , Kumkumian Gregory , Murphy Mandy , Greenberg Ann , Iraola Margaret , Sedlis Steven P. , Maranan Leandro C. , Donnino Robert M. , Lorin Jeffrey , Tamis-Holland Jacqueline E. , Malinay Ammy , Kornberg Robert , Leber Robert , Saba Souheil , Edillo Candice P. , Lee Michael W. , Small Delano R. , Nona Wassim , Alexander Patrick B. , Rehman Iram , Badami Umesh , Ostrander Ann , Wasmiller Stephanie , Marzo Kevin , Drewes Wendy , Patel Dipti , Robbins Inga H. , Levite Howard A. , White Jackie M , Shetty Sanjay , Hallam Alison , Patel Mayuri , Hamroff Glenn S. , Spooner Benjamin J , Hollenweger Linda M , Little Raymond W. , Little Holly , Zimbelman Brandi D. , Little Tiffany , Lui Charles Y. , Eskelson Nona A , Smith Brigham R. , Vezina Daniel P. , Khor Lillian L. , Abraham Josephine D. , Bull David A. , McKellar Stephen H. , Booth David , Taul Yvonne , Kotter John , Rodgers Caroline , Abdel-Latif Ahmed , Isaacs Jennifer , Bulkley Viktoria , Hu Bob , Kaneshiro Renee , Labovitz Arthur J. , Berlowitz Michael , Kirby Bonnie J. , Rogal Philip , Tran Nhi N. , McFarren Christopher , Jahrsdorfer Catherine , Matar Fadi , Caldeira Christiano , Rodriguez Fatima , Yunis Reem , Schnittger Ingela , Patro Jhina , Fearon William F. , Deedwania Prakash , Vega Antonia , Reddy Kiran , Sweeny Joseph , Bloise-Adames Hugo , Jimenez Santa , Saint Vrestil Nicole , Bhandari Reyna , Spizzieri Christopher , Schade Danielle , Yost Roxanne , Hochberg Claudia P , Beardsley Paula , Fine Denise , Salerno William D. , Tancredi Jana , Arakelian Patricia , Mathus Susan , O’Neill Deborah , Wyman Ray , Burkhardt Joy , Hosino Suellen , Lubyanaya Oksana A. , Salas Jose D. , Zarka Amer , Aguirre Maria , Shah Anil V. , Dhawan Manu , Parra Diana , Tran Tri , Haldis Thomas , Weick Catherine , Fowler-Lehman Katie , Spitzer Natalie , Riedberger Casey , Weick Catherine , Kohn Jeffrey A. , Cobos Stanley E. , Dwyer Raven R. , Espinosa Dalisa , Quiles Kirsten J. , Girotra Saket , Drum Carrie , Miller-Cox Kimberly , Ollinger Amy , Almousalli Omar , Capasso-Gulve Elizabeth , Melanie Loehr Alaine , Mosley Marlowe , Krishnam Mayil S. , Heydari Shirin , Milliken Jeffrey C. , Lundeen Andrea M. , Patel Pranav M. , Karanjah Edgar , Seto Arnold H. , Marfori Wanda C. , Harley Kevin T. , Hernandez-Rangel Eduardo , Gibson Michael A. , Singh Pam , Allen Byron J. , Coram Rita , Marie Webb Anne , Fridell Ellie , Wilson Heidi , Thomas Sabu , Kim Angela , Schwartz Ronald G , Wilmot Patrick , Chen Wei , El Shahawy Mahfouz , Stevens Ramona , Stafford James , Black Loriane , Abernethy William B. , Hull Amber B. , Lim Olivia J. , Tucker Helen C. , Putnam Natasha C. , Hall Linda L. , Cauthren Tia , Tucker Trish , Zurick Andrew , Horton Hollie , Orga Jan , Meyer Thomas M. , White Joyce R. , Morford Ronald G. , Baumann Cynthia , Rutkin Bruce , Seeratan Vidya , Bokhari Sabahat , Jimenez Magnolia , Sokol Seth I. , Schultz Cidney , Meisner Jay , Russo Jeanne , Hamzeh Ihab , Misra Arunima , Huda Zohra , Wall Jr. Matthew , Boan Araceli , Lenges De Rosen Veronica , Alam Mahboob , Turner Michael C. , Hinton Christine R , Mulhearn Thomas J. , Good Arnold P. , Archer Beth A. , Dionne Julia S. , Allardyce Cheryl A. , Sikora Lindsey N. , Czerniak Jennifer H. , Mull Jennifer A. , Ferguson Elizabeth , Laube Frances , Shammas Nicolas W. , Shammas Gail A , Christensen Lori , Park Holly , Chilton Robert , Hecht Joan , Nguyen Patricia K. , Vo Davis , Hirsch James , Jezior Matthew , Bindeman Jody , Salkind Sara , Espinosa Dalisa , Desimone Lori-Ann , Gordon Paul C. , Felix-Stern Lina , Crain Thomas , Gomes Jassira , Gordon Catherine , Stenberg Robert , Mann Aimee , McCreary Theresa , Pedalino Ronald P. , Cobos Stanley E. , Dwyer Raven R. , Espinosa Dalisa , Quiles Kirsten J. , Wiesel Joseph , Cobos Stanley E. , Dwyer Raven R. , Espinosa Dalisa , Quiles Kirsten J. , Juang George J. , Gopaul Candace , Hultberg Karen , Huk Tauqir , Hussain Afshan , Al-Amoodi Mohammed , Zambrano Yesenia , Medina Rodriguez Sarah , Milner Trudie , Wohns David , Mulder Abbey , Van Oosterhout Stacie , Lader Ellis W. , Meyer Martha , Mumma Michael , Clapp Nancy L. , Barrentine Heather , Dharmarajan Lekshmi , Jose Jenne M. , Cobos Stanley E. , Dwyer Raven R. , Espinosa Dalisa , Quiles Kirsten J. , Manchery Jenne , McGarvey Jr Joseph F.X. , McKinney Vera , Schwarz Linda , Downes Thomas R. , Kaczkowski Scott M. , Luckasen Gary J. , Jaskowiak Adam J. , Klitch Joel , Cheong Benjamin , Dees Debra , Potluri Srinivasa , Vasquez Precilia , Mastouri Ronald A. , Breall Jeffery A. , Hannemann Elise L. , Revtyak George E. , Mae Foltz Judy , Bazeley Jonathan W. , Li Dayuan , DeRosa Emily , Jorgenson Beth , Riestenberg-Smith Joyce , Giedd Kenneth , Old Wayne , Bariciano Rebecca , Burt Francis , Sokhon Kozhaya , Waldron Jessica , Mayon Michelle , Gopal Deepika , Valeti Uma S. , Ann Peichel Gretchen , Kobashigawa Jon , Starks Brandy , Garcia Lucilla , Thottam Maria , Bhargava Balram , Anand Anjali , Chakanalil Govindan Sajeev , Raj Janitha , Gopalan Nair Rajesh , Ravindran Reshma , Rajalekshmi VS , Nataraj Nandita , Moorthy Nagaraja , Nayak Soundarya , Mylarappa Mahevamma , Narayanappa Suryaprakash , Pandit Neeraj , Bajaj Sheromani , Kumar Nath Ranjit , Yadav Vandana , Mishra Girish , Dwivedi S.K. , Tewari Roma , Narain V.S. , Mishra Meenakshi , Chandra Sharad , Patel Shivali , Singh Suman , Wander Gurpreet S. , Tandon Rohit , Ralhan Sarju , Kaur Baljeet , Aslam Naved , Gupta Sonika , Goyal Abhishek , Bhargava Balram , Suvarna Chandini , Karthikeyan G. , Ramakrishnan S. , Seth Sandeep , Yadav Rakesh , Singh Sandeep , Roy Ambuj , Parakh Neeraj , Kumar Verma Sunil , Narang Rajiv , Mishra Sundeep , Naik Nitish , Sharma Gautam , Kumar Choudhary Shiv , Patel Chetan , Gulati Gurpreet , Sharma Sanjeev , Bahl V K , Mathew Anoop , Mannekkattukudy Kurian Binoy , Punnoose Eapen , Avdhoot Gadkari Milind , Rupesh Karwa Sheetal , Gadage Siddharth , Kolhe Suvarna , Umesh Pillay Tapan , Satheesh Santhosh , Vindhya R. J. , Jain Peeyush , Seth Ashok , Singh Meharwal Zile , Mathur Atul , Verma Atul , Kaul Upendra , Bhatia Mona , Sachdeva Ankush , Indira Devi Thounaojam , Jungla Nungshi , Christopher Johann , Manjula Rani K. , Menon Rajeev , Sowjanya Reddy M. , Kumar Nirmal , Preethi K. , Oomman Abraham , sidh Rinu R , Mao Robert , Ramakrishnan T. , Solomon Hilda , Francis Rajesh , Naik Sudhir , Vamshi Priya P. , Parveen Khan Sajeeda , Christopher Johann , Preethi Kotiboinna , Kumar Nirmal , Grant Purvez , Hande Shweta , Sonawane Poonam , Kachru Ranjan , Dubey Abhishek , Rawat Kavita , Kumar Ajit , Ganapathi Sanjay , K Jayakumar , CP Vineeth , Sivadasanpillai Harikrishnan , Chacko Manas , Sasidharan Bijulal , Babu Suresh , TR Kapilamoorthy , Christopher Johann , Reddy Sowjanya , Polamuri Praneeth , Rani Manjula , Kaul Upendra , Arambam Priyadarshani , Singh Bebek , Senior Roxy , Fox Keith AA , Young Grace M. , Carruthers Kathryn , Senior Roxy , Elghamaz Ahmed , Gurunathan Sothinathan , Karogiannis Nikolaos , Young Grace M. , Shah Benoy N , Kinsey Christopher , Trimlett Richard HJ , Kavalakkat Raisa , Rubens Michael B , Evans Jo , Nicol Edward D , Hassan Ikraam , Mittal Tarun K , Hampson Reinette , Andreas Gamma Reto , Williams Sarah , Holland Kim , Swan Karen , de Belder Mark A , Atkinson Bev , Thambyrajah Jeet , Kunhunny Swapna , Davies John R , Lindsay Steven J. , Atkinson Craig , Kurian John , Krannila Carita , Jamil Haqeel , Vinod Manitha , Raheem Osama , Hoye Angela , Chaytor Lisa , Cox Leanne , Morrow Julie , Rowe Kay , Donnelly Patrick , Kelly Stephanie , Valecka Bernardas , Regan Susan , Turnbull Dawn , Chauhan Anoop , Fleming Catherine , Ghosh Arijit , Gratrix Karen , Preston Stephen , Barr Craig , Cartwright Anne , Alfakih Khaled , Knighton Abigail , Byrne Jonathan , Martin Katherine , Webb Ian , Henriksen Peter , Flint Laura , Harrison James , OKane Peter , Lakeman Nicki , Ljubez Anja , de Silva Ramesh , Conway Dwayne S. G. , Wright Judith , Exley Donna , Sirker Alexander A , Andiapen Mervyn , Richards Amy J. , Hoole Stephen P , Wong Lisa , Witherow Fraser N. , Munro Melanie J. , Johnston Nicola , Harbinson Mark , McEvoy Michelle , Walsh Simon , Brown Caroline , Douglas Hanna , Luckie Matthew , Charles Thabitha , Kolakaluri Laurel , Phillips Hannah , Sobolewska Jolanta , Morby Louise , Hallett Karen , Corbett Carolyn , Winstanley Lynne , Jeetley Paramjit , Smit Angelique , Patel Niket , Kotecha Tushar , Travill Christopher , Gent Susan , Karimullah Iqbal , Hussain Nafisa , Al-Bustami Mahmud , Braganza Denise , Haines Fiona , Taaffe Joanne , Henderson Robert , Burton Jane , Pointon Kate , Colton Maria , Naik Surendra , King Rachel , Mathew Thomas , Brown Ammani , Docherty Andrew , Berry Colin , McCloy Lisa , Collison Damien , Robb Kate , Roditi Giles , Paterson Craig , Crawford Wenda , Kelly Joanne , McGregor Lorraine , Moriarty Andrew J , Mackin Anne , Glover Jason D. , Knight Janet P , Pradhan Jiwan , Mikhail Ghada , Bose Tuhina , Francis Darrel P. , Dzavik Vladimir , Goodman Shaun , Gosselin Gilbert , Gosselin Gilbert , Proietti Anna , Brousseau Myriam , Corfias Magalie , Blaise Patricia , Harvey Luc , Diaz Ariel , Rheault Philippe , Barrero Miguel , Gagné Carl-Éric , Alarie Patricia , Pépin-Dubois Yanek , Arcand Linda , Costa Ricardo , Roy Isabelle , Tung Sia Ying , Montpetit Estelle , Lemay Catherine , Gisbert Alejandro , Gervais Pierre , Rheault Alain , Drouin Katia , Carl Phaneuf Denis , Bergeron Christine , Gosselin Gilbert , Shelley Christine , Masson Christine , Garg Pallav , Carr Sandy , Bone Catherine , Chow Benjamin J.W. , Moga Ermina , Hessian Renee C. , Kourzenkova Janetta , Beanlands Rob S. , Walter Olga , Davies Richard F. , Bainey Kevin R. , Hogg Norma , Welsh Suzanne , Cheema Asim N. , Bagai Akshay , Wald Ron , Goodman Shaun , Kushniriuk Khrystyna , Joseph Graham John , Hussain Mohammed , Peterson Mark , Bello Olugbenga , Chow Chi-Ming , Abramson Beth , Nazir Cheema Asim , Syed Ishba , Hussain Mohammed , Kushniriuk Khrystyna , Cha James , Otis Judy , Otis Rebecca , Howarth Andrew G , Seib Michelle M , Rivest Sandra M , Sandonato Rosa , Wong Graham , Chow Jackie , Starovoytov Andrew , Uchida Naomi , Meadows Ngaire , Uxa Amar , Asif Nadia , Tavares Suzana , Galiwango Paul , Bozek Bev , Kassam Saleem , Shier Maria , Mukherjee Ashok , Larmand Lori-Ann , Ricci A. Joseph , Janmohamed Amir , Hart Brenda , Lam Andy , Marucci Jane , Tai Sharon , Mehta Shamir , Brons Sonya , Beck Chris , Wong Glenda , Etherington Krystal , Arumairajah Thippeekaa , Udell Jacob , Aprile Maria , Karlsson Sara , Webber Susan , Généreux Philippe , Mercure Chantale , Hameed Adnan , Aedy Nancy , Daba Ledjalem , Farquharson Fran , Siddiqui Anam , Carlos Carvalho Antonio , Lopes Renato D. , Hueb Whady , Emy Takiuti Myrthes , Cury Rezende Paulo , Eustáquio Ribeiro Silva Expedito , Ciappina Hueb Alexandre , Pizzol Caetano Leonardo , Schaan de Quadros Alexandre , Abdala Karam Kalil Renato , Peixoto Deiro Aline , Luiz da Costa Vieira José , Manica Muller Alice , Antonieta Pereira de Moraes Maria , Píccaro de Oliveira Pedro , Maria Ascoli Bruna , Bridi Leonardo , Zottis Poletti Sílvia , Savaris Simone , Vitola João V , Cerci Rodrigo J , Zier Sandra S. , Farias Fabio R , Veiga Jr Vilmar , Fernandes Miguel M , Antonio Marin-Neto José , Schmidt André , de Oliveira Lima Filho Moysés , Franca da Cunha Diego , Mendes Oliveira Ricardo , Reynaldo Abbud Chierice João , Polanczyk Carísi A. , Rucatti Guilherme G , Furtado Mariana V. , Igansi Fernanda , Smidt Luis F. , Haeffner Mauren P , Carlos Carvalho Antonio , Almeida Viviane , Pucci Gustavo , Sanchez de Souza Gabriela , Lyra Flavio , Rabelo Alves Junior Alvaro , Almeida Mayana , dos Santos Viviane , Dracoulakis Marianna D. A. , Oliveira Natalia S , Lima Rodolfo G. S. D , Figueiredo Estevao , Edilena Paulino Azevedo Bruna , Ricardo Caramori Paulo , Bizzaro Santos Marco , Germann Amanda , Gomes Vitor , Homem Rosa , Magedanz Ellen , Tumelero Rogerio , Laimer Rosane , Tognon Alexandre , Dall’Orto Frederico , Mesquita Claudio T. , Santos Roberta P , Colafranseschi Alexandre S. , Oliveira Jr. Amarino C. , Carvalho Luiz A. , Palazzo Isabella C. , Sousa Andre S. , Eustáquio Ribeiro da Silva Expedito , Gabriel Melo de Barros e Silva Pedro , Yumi Okada Mariana , de Pádua Silva Baptista Luciana , Paula Batista Ana , Jamus Rodrigues Marcelo , Nogueira Rabaça Aline , Valério Coimbra de Resende Marcos , Francisco Saraiva Jose , Miranda Trama Larissa , Silva Talita , Thais de Souza Ormundo Camila , Vicente Carla , Costantini Costantino , Pinheiro Caroline , Komar Daniele , Szwed Hanna , Demkow Marcin , Kepka Cezary , Teresinska Anna , Walesiak Olga , Kryczka Karolina , Malinowska Katarzyna , Henzel Jan , Solecki Mateusz , Kaczmarska Edyta , Mazurek Tomasz , Maksym Jakub , Wojtera Karolina , Fojt Anna , Szczerba Ewa , Drozdz Jaroslaw , Czarniak Bartosz , Frach Malgorzata , Szymczyk Konrad , Niedzwiecka Iwona , Sobczak Sebastian , Ciurus Tomasz , Jakubowski Piotr , Misztal-Teodorczyk Magdalena , Teodorczyk Dawid , Swiderek Marta , Fratczak Aleksandra , Wojtala Ewelina , Szkopiak Marcin , Lebioda Patrycja , Wlodarczyk Michal , Plachcinska Anna , Kusmierek Jacek , Miller Magdalena , Marciniak Halina , Wojtczak-Soska Karolina , Łuczak Katarzyna , Tarchalski Tomasz , Cichocka-Radwan Anna , Szwed Hanna , Karwowski Jaroslaw , Anna Szulczyk Grazyna , Witkowski Adam , Kukuła Krzysztof , Celińska-Spodar Małgorzta , Zalewska Joanna , Gajos Grzegorz , Bury Krzysztof , Pruszczyk Piotr , Łabyk Andrzej , Roik Marek , Szramowska Agnieszka , Zdończyk Olga , Łoboz-Grudzień Krystyna , Jaroch Joanna , Sokalski Leszek , Brzezińska Barbara , Lesiak Maciej , Łanocha Magdalena , Reczuch Krzysztof W. , Kolodziej Adam , Kalarus Zbigniew , Swiatkowski Andrzej , Szulik Mariola , Musial Wlodzimierz J. , Marcinkiewicz-Siemion Marta , Bockeria Olga , Bockeria Leo , Bockeria Olga , Petrosyan Karen , Kudzoeva Zalina , Trifonova Tatiana , Aripova Nodira , Chernyavskiy Alexander M. , Naryshkin Ivan A. , Kretov Evgeniy I. , Kuleshova Alena , Grazhdankin Igor O. , Malaev Dastan , Bershtein Leonid L. , Sayganov Sergey A. , Subbotina Irina , Kuzmina-Krutetskaya Anastasia M. , Gumerova Victoria , Zbyshevskaya Elizaveta V. , Katamadze Nana O. , Nikolaeva Olga B. , Kozlov Pavel S. , Kozulin Vikentiy Y. , Lubinskaya Ekaterina I. , Luis Lopez-Sendon Jose , Castro Almudena , Lopez-Sendon Jose , Fernández-Figares Virginia , Castro Almudena , Refoyo Salicio Elena , Guzman Gabriela , Galeote Gabriel , Valbuena Silvia , Peteiro Jesús , Dolores Martínez-Ruíz María , Pérez-Fernández Ruth , Blanco-Calvo Moisés , Cuenca-Castillo José J , Alonso-Álvarez Encarnación , Flores-Ríos Xacobe , García-González Paula , Prada-Delgado Óscar , Barge-Caballero Gonzalo , Ramon Gonzalez Juanatey Jose , Seijas Amigo Jose , Souto Bayarri Miguel , Pubull Nuñez Virginia , Ocaranza Sanchez Raymundo , Cid Alvarez Belen , Peña Gil Carlos , Martinez Monzonis Amparo , Sionis Alessandro , Fernández Martínez Ana , Vila Perales Montserrat , Maria Padró Josep , Serra Peñaranda Antonio , García Picart Joan , Ginel Iglesias Antonino , Garcia-Moll Marimon Xavier , Pons Lladó Guillem , Carreras Costa Francesc , Miro Vicente , Igual Begoña , Diez Jose L , Calvillo Pilar , Ortuño F. Marin , Valdés Chávarri M. , Quintana Giner M. , Tello Montolliu A. , Romero Aniorte A.I. , Pinar Bermudez E. , Rivera Caravaca JM. , De La Morena G. , Gracida Blancas Montserrat , Cañavate Olga , Guerrero Sonia , Riera Silvia , Enrique Castillo Luena Jose , Enrique Castillo Luena Jose , Lasala Maria , Fernandez-Aviles Francisco , Lorenzo Maria , Sobrino Olga , Vazquez Alexandra , Jiang Lixin , Chen Jiyan , Dong Haojian , He Peiyu , Xia Chunli , Yang Junqing , Zhong Qi , Wu Yongjian , Tian Yanmeng , Li Dongze , Ma Yitong , Li Xiaomei , Yang Yining , Ma Xiang , Yu Zixiang , Zhao Qian , Ji Zheng , Li Chunguang , Zhang Lei , Zhao Yu , Zhu Bolin , Yang Xinchun , Chen Mulei , Chi Hongjie , Wang Yang , Zhang Jing , Lin Wenhua , Jing Rui , Liu Jingjing , Zeng Hesong , Zhou Qiang , Xu Chang , Li Zhuxi , Li Junhua , Xiong Luyang , Fu Xin , Gao Dan , Jiang Dengke , Leng Ran , Wang Xutong , Yuan Qianqian , Zhang Lili , Yang Bin , Bai Ziliang , Li Jianhua , Qi Jie , Wang Fei , Wang Haitao , Yang Bin , Yue Zhou , Zhang Zhulin , Wang Songtao , Dong Yumei , Mao Jiajia , Zhang Bin , Cheng Gong , Li Xiuhong , Yao Xiaowei , Zhong Nier , Zhou Ning , Zhao Yulan , Huang Yaping , Zhou Panpan , Fang Xuehua , Su Wei , Zeng Qiutang , Kunwu Yu , Peng Yudong , Su Xin , Su Xi , Wang Chen , Zhao Yunhai , Li Qingxian , Geng Yaming , Wang Yanfu , Nie Shao-ping , Fan Jing-yao , Feng Si-ting , Wang Xiao , Yan Yan , Zhang Hui-min , Yu Qin , Chi Lingping , Liu Fang , Wang Jian’an , Chen Han , Jiang Jun , Li Huajun , Wang Jian’an , Han Yechen , Xu Lihong , Zhang Shuyang , Liu Zhenyu , Liu Zhenyu , Chen Gang , Hu Rongrong , Maggioni Aldo P. , Piero Perna Gian , Pietrucci Francesca , Marini Marco , Gabrielli Gabriele , Provasoli Stefano , Di Donato Anna , Verna Edoardo , Monti Lorenzo , Nardi Barbara , Di Chiara Antonio , Pezzetta Francesca , Mortara Andrea , Casali Valentina , Galvani Marcello , Attanasio Chiara , Ottani Filippo , Sicuro Marco , Leone Gianpiero , Pisano Francesco , Bare Cristina , Calabro Paolo , Fimiani Fabio , Formisano Tiziana , Tarantini Giuseppe , Barioli Alberto , Cucchini Umberto , Ramani Federica , Luigi Andres Anto , Racca Emanuela , Rolfo Fabrizio , Goletto Cecilia , Briguori Carlo , De Micco Francesca , Amati Roberto , Di Marco Stefano , Vergoni William , Tricoli Martina , Russo Aldo , Villella Massimo , Fanelli Raffaele , Douglas White Harvey , Alsweiler Caroline , Poh Kian-Keong , Chai Ping , Lau Titus , Loh Joshua P. , Tay Edgar L. , Teoh Kristine , Tan Sik-Yin V , Teo Lynette L. , Sia Winnie C , Ong Ching-Ching , Leong Audrey W , Wong Raymond C. , Loh Poay-Huan , Kofidis Theodoros , Xian Chan Wan , Hui Chan Koo , Foo David , Hai Yan Li , Loh Kwok Kong Jason , Min Er Ching , Haider Jafary Fahim , Chua Terrance , Ismail Nasrul , Tun Kyaw Min , Yip Deborah , Doerr Rolf , Doerr Rolf , Stumpf Juergen , Grahl Dorit , Matschke Klaus , Guenther Franziska , Simonis Gregor , Bonin Kerstin , Kadalie Clemens T. , Sechtem Udo , Wenzelburger Ina , Ong Peter , Gruensfelder Susanne , Christian Schulze P. , Goebel Bjoern , Lenk Karsten , Nickenig Georg , Sinning Jan-Malte , Weber Marcel , Werner Nikos , Marthe Lang Irene , Huber Kurt , Schuchlenz Herwig , Steinmaurer Gudrun , Weikl Stefan , Marthe Lang Irene , Winter Max-Paul , Andric Tijana , Huber Kurt , Tscharre Maximilian , Jakl-Kotauschek Gabriele , Wegmayr Claudia , Jäger Bernhard , Egger Florian , Keltai Matyas , Vertes Andras , Sebo Judit , Davidovits Zoltan , Matics Laszlone , Varga Albert , Ágoston Gergely , Fontos Geza , Dekany Gabor , Merkely Bela , Bartykowszki Andrea , Maurovich-Horvat Pal , Kerecsen Gabor , Jakal Agnes , Hinic Sasa , Djokic Jelena , Zdravkovic Marija , Mudrenovic Vladan , Crnokrak Bogdan , Beleslin Branko D. , Boskovic Nikola N. , Djordjevic-Dikic Ana D. , Petrovic Marija T. , Giga Vojislav L. , Dobric Milan R. , Stepanovic Jelena J. , Markovic Zeljko Z. , Mladenovic Ana S. , Cemerlic-Adjic Nada , Velicki Lazar , Kamenica Sremska , Pupic Ljiljana , Davidović Goran , Simović Stefan M. , Vučić Rada , Dekleva Milica Nikola , Martinovic Miroslav Stevo , Stevanovic Gordana , Stankovic Goran , Dobric Milan , Apostolovic Svetlana , Martinovic Sonja Salinger , Stanojevic Dragana , Escobedo Jorge , Jesús-Pérez Ramon de , Juarez Benito , Baleón-Espinosa Rubén , Campos-Santaolalla Arturo S , Durán-Cortés Elihú , Flores-Palacios José M , García-Rincón Andrés , Jiménez-Santos Moisés , Peñafiel Joaquín V , Ortega-Ramírez José A , Valdespino-Estrada Aquiles , Rosas Erick Alexánderson , Canales Brassetti María Fernanda , Vences Anaya Diego Adrián , García María Pérez , Carvajal Juarez Isabel Estela , Rovalo Magdalena Madero , Morales Rodríguez Erick Donato , Selvanayagam Joseph B. , Rankin Jamie , Murphy Deirdre , Selvanayagam Joseph B. , Lee Sau , Joseph Majo X. , Thomas Prince , Thambar Suku T. , Chaplin Melissa D , Boer Stephanie C , Beltrame John F. , Stansborough Jeanette K. , Black Marilyn , Hillis Graham S. , Bonner Michelle M. , Ireland Kim F. , Venn-Edmonds Clare , Steg Philippe-Gabriel , Abergel Helene , Juliard Jean-Michel , Thobois Corine , Pasteur C.H. Louis , Thuaire Christophe , Tachot Emilie , Dutoiu Téodora , Laure Christophe , Vassaliere Christel , Steg Philippe Gabriel , Abergel Helene , Juliard Jean-Michel , Fuentes Axelle , Slama Michel S. , Eliahou Ludivine , Cedex Clamart , El Mahmoud Rami , Dubourg Olivier , Michaud Pierre , Nicollet Eric , Hadjih Sarah , Cedex Corbeil-Essonnes , Goube Pascal , Brito Patricia , Barone-Rochette Gilles , Barone-Rochette Gilles , Furber Alain , Cornet Charles , Bière Loïc , Rautureau Jeremy , Juceviciene Agne , Kalibataite-Rutkauskiene Irma , Keinaite Laura , Laucevicius Aleksandras , Laukyte Monika , Celutkiene Jelena , Mikolaitiene Gelmina , Smigelskaite Akvile , Tamasauskiene Ilona , Urboniene Agne , Kedhi Elvin , Klinieken Isala , Timmer Jorik , Bouwhuis Ilse , Hermanides Rik , Nijmeijer Lia , Kaplan Eliza , Riezebos Robert K. , Samadi Pouneh , Schoep Jeannette, J. M. , Dongen Elise van , Janzen Elisabeth, M. , Niehe Sander R. , Suryapranata Harry , Ahoud Sandra , Vugt Stijn van , Ramos Ruben , Santa Marta Hospital de , Cacela Duarte , Santana Ana , Fiarresga Antonio , Sousa Lidia , Marques Hugo , Patricio Lino , Selas Mafalda , Bernanrdes Luis , Silva Filipa , Rio Pedro , Freixo Cláudia , Carvalho Ramiro , Ferreira Rui , Silva Tiago , Rodrigues Ines , Modas Pedro , Portugal Guilherme , Fragata Jose , Pinto Fausto J. , Cabrita Inês Zimbarra , Menezes Miguel Nobre , Rocha Andreia , Lopes Guilhermina Cantinho , Figueiras Francisca Patuleia , Almeida Ana Gomes , Coelho Andreia , CanVas Silva Pedro , Capinha Marta , Nobre Angelo , Caetano Maria Inês , Francisco Ana Rita , Silva Susana , Ferreira Nuno , de Gaia Vila Nova , Lopes Ricardo L. , Diaz Rafael , Guzman Luis , Tinnirello Veronica , Figal Julio César , Nicolás Mungo Matías , Buenos Aires Ciudad Autonoma de , Méndiz Oscar , Cortés Claudia , Favaloro Roberto René , Alvarez Carlos , Garcia Marina , Blanca Bahia , Courtis Javier , Godoy Valeria , Zeballos Gabriela , Schiavi Lilia , Actis Maria Victoria , Rubio Mariano , Scaro Graciela , White Harvey Douglas , Alsweiler Caroline , Devlin Gerard Patrick , Low Liz , Fisher Raewyn , Scales Jayne , Abercrombie Kirsty , Stewart Ralph Alan Huston , Howell Leah , White Harvey Douglas , Patten Cathrine , Benatar Jocelyne , Kedev Sasko , Mitevska Irena Peovska , Kostovska Elizabeta Srbinovska , Pejkov Hristo , Held Claes , Held Claes , Eggers Kai , Frostfelt Gunnar , Björklund Christina , Johnston Nina , Andreasson Maria , Olsowka Maciej , Essermark Marie , Åkerblom Axel , Soveri Inga , Aspberg Johannes , Persson Liselotte , Beyar Rafael , Sharir Tali , Nikolsky Eugenia , Sharir Tali , Harel Or , Elian Dan , Kerner Arthur , Bentzvi Margalit , Massalha Samia , Helmer Ludmila , Kohsaka Shun , Fukuda Keiichi , Ueda Ikuko , Kohsaka Shun , Fujita Jun , Yasuda Satoshi , Furukawa Akemi , Hirase Kanae , Nagai Toshiyuki , Otsuka Fumiyuki , Nishimura Shigeyuki , Nakano Shintaro , de Werf Frans Van , Goetschalckx Kaatje , Goetschalckx Kaatje , Robesyn Valerie , de Werf Frans Van , Claes Kathleen , White Harvey Douglas , Alsweiler Caroline , Hung Chung-Lieh , Yang Yi-Hsuan , Yun Chun-Ho , Hou Charles Jia-Yin , Kuo Jen-Yuan , Yeh Hung-I , Hung Ta-Chuan , Li Jiun-Yi , Chien Chen-Yen , Tsai Cheng-Ting , Liu Chun-Chieh , Yu Fa-Chang , Lin Yueh-Hung , Lan Wei-Ren , Yen Chih-Hsuan , Tsai Jui-Peng , Sung Kuo-Tzu , Ntsekhe Mpiko , Pandie Shaheen , Philander (Nee Talliard) Constance , Viljoen Charle A , Mtana Noloyiso , De Andrade Marianne , Maggioni Aldo P. , Moccetti Tiziano , Anesini Adriana , Rossi M.Grazia , Maspoli Simona , Mombelli Manuela , Abdelhamid Magdy , Talaat Ahmed , Adel Ahmed , Kamal Ahmed , Mahrous Hossam , Kaffas Sameh El , Fishawy Hussien El , Pop Calin , Claudia Matei , Popescu Bogdan A. , Ginghina Carmen , Rosca Monica , Deleanu Dan , Beladan Carmen C. , Iliescu Vlad A. , Al-Mallah Mouaz H. , Zahrani Sarah , Aljzeeri Ahmed , Najm Hani , Alghamdi Ali , Mogrovejo Ramos Walter Enrique , Monsalve Davila Marco Antonio , White Harvey Douglas , Alsweiler Caroline , Kuanprasert Srun , Mai Chiang , Prommintikul Arintaya , Nawarawong Weerachai , Khwakhong Supatchara , Woragidpoonpol Surin , Chaiyasri Anong , Tepsuwan Thitipong , Mekara Warangkana , Taksaudom Noppon , Kulthawong Supap , Rimsukcharoenchai Chataroon , Amaritakomol Anong , Euathrongchit Juntima , Wannasopha Yutthaphan , Yamwong Sukit , Panpunuan Pachara , Sritara Piyamitr , Aramcharoen Suthara , Meemuk Krissada , White Harvey Douglas , Alsweiler Caroline , Khairuddin Ahmad , Mokhtar Noor Syamira , Hadi Hafidz Abd , Basri Nor Asiah , Yahaya Shaiful Azmi , Yusnida Irni , Hashim Humayrah , Harrington Robert , Williams David , Alexander Karen P. , Berger Jeffrey , Harrington Robert , Mark Daniel , O’Brien Sean M. , Rosenberg Yves , Shaw Leslee J. , Ballantyne Christie , Berman Daniel , Beyar Rafael , Bhargava Balram , Buller Chris , (Tony) Carvalho* Antonio , Chaitman Bernard R. , Diaz Rafael , Doerr Rolf , Dzavik Vladimir , Goodman Shaun , Gosselin Gilbert , Hachamovitch Rory , Hamm Christian , Held Claes , Helm Malte , Huber Kurt , Jiang Lixin , Keltai Matyas , Kohsaka Shun , Lang Irene , Lopes Renato , Lopez-Sendon Jose , Maggioni Aldo , Bairey Merz C. Noel , Min James , Peterson Eric , Picard Michael H. , Selvanayagam Joseph , Senior Roxy , Sharir Tali , Steg Gabriel , Szwed Hanna , de Werf Frans Van , Weintraub William , White Harvey , Williams David , Ballantyne Christie , Calfas* Karen , Chaitman Bernard R. , Champagne Mary Ann , Davidson Michael , Fleg Jerome , McCullough Peter A. , Stone Peter , Menasche Philippe , Davidson* Michael , Fremes Stephen , Guyton Robert , Mack Michael , Mohr Fred , Rao Anupama , Sabik Joe , Shapira Oz , Taggart David , Tatoulis James , Williams David , Blankenship Jim , Brener Sorin , Buller Chris , Colombo Antonio , Bruyne Bernard de , Généreux Philippe , Harrington Robert , Kereiakes Dean , Lefevre Thierry , Moses Jeffrey , Chaitman Bernard R. , Alexander Karen P. , Mahaffey Ken , White Harvey , Chaitman Bernard R. , Cruz-Flores Salvador , Danchin Nicholas , Feen Eli , Garcia Mario J. , Hauptman Paul , Laddu Abhay A. , Passamani Eugene , Pina Ileana L. , Simoons Maarten , Skali Hicham , Thygesen Kristian , Waters David , Alexander Karen P. , Endsley Patricia , Esposito Gerard , Kanters Jeffrey , Pownall John , Stournaras Dimitrios , Shaw Leslee J. , Berman Daniel , Friedrich Matthias , Hachamovitch Rory , Kwong Raymond , Min James , Oliver Dana , Picard Michael H. , Harrell Frank , Blume Jeffrey , Lee Kerry , O’Brien Sean M. , Berger Jeffrey , Held Claes , Kullo Iftikhar , McManus Bruce , Newby Kristin , Mark Daniel , Cohen David , Weintraub William , Merz C. Noel Bairey , Bugiardini Raffaele , Celutkiene Jelena , Escobedo Jorge , Hoye Angela , Lyubarova Radmila , Mattina Deirdre , Peteiro Jesus , Alexander Karen P. , Berger Jeffrey , Harrington Robert , O’Brien Sean M. , Rosenberg Yves , Mark Daniel , Mark Daniel , Shaw Leslee J. , Berman Dan , Chaitman Bernard R. , Fleg Jerome , Kwong Raymond , Picard Michael H. , Senior Roxy , Min James , Leipsic Jonathan , Ali Ziad , Williams David , Fleg Jerome , Berger Jeffrey , Chaitman Bernard R. , Alexander Karen P. , Alexander Karen P. , Fleg Jerome , Mathew Roy , O’Brien Sean M. , Sidhu Mandeep , Friedman Lawrence , Anderson Jeffrey , Berg Jessica , DeMets David , Gibson C. Michael , Lamas Gervasio , Deming Nicole , Himmelfarb Jonathan , Ouyang Pamela , Woodard Pamela , Harrell Frank , Nwosu Samuel , Rosenberg Yves , Fleg Jerome , Kirby Ruth , Jeffries Neal , Berger Jeffrey , Sidhu Mandeep , Denaro* Jean E. , Mavromichalis Stephanie , Chan Kevin , Cobb Gia , Contreras Aira , Cukali Diana , Ferket Stephanie , Gabriel Andre , Hansen Antonietta , Roberts Arline , Chang Michelle , Islam Sharder , Wayser Graceanne , Yakubov Solomon , Yee Michelle , Callison Caroline , Hogan Isabelle , Qelaj Albertina , Pirro Charlotte , Loo Kerrie Van , Wisniewski Brianna , Gilsenan Margaret , Lang Bevin , Mohamed Samaa , Esquenazi-Karonika Shari , Mathews Patenne , Naumova Anna , Lyo Jihyun , Setang Vincent , Xavier Mark , O’Brien Sean M. , Alexander Karen P. , Mark Daniel B. , Anstrom Kevin , Baloch Khaula , Blount Janet , Cowper Patricia , Davidson-Ray Linda , Drew Laura , Harding Tina , Knight J David , Liu Diane Minshall , O’Neal Betsy , Redick Thomas , Jones Philip , Nugent Karen , Wang Grace Jingyan , Shaw Leslee J. , Phillips Lawrence , Goyal Abhinav , Hetrick Holly , Oliver Dana , Berman Daniel , Hayes Sean W. , Friedman John D. , Gerlach R. James , Hyun Mark , Miranda-Peats Romalisa , Slomka Piotr , Thomson Louise , Kwong Raymond Y. , Friedrich Matthias , Mongeon Francois Pierre , Michael Steven , Picard Michael H. , Hung Judy , Scherrer-Crosbie Marielle , Zeng Xin , Chaitman Bernard R. , Eckstein Jane , Guruge Bandula , Streif Mary , Ali Ziad , Genereux Philippe , Alfonso Maria A. , Corral Maria P. , Garcia Javier J. , Horst Jennifer , Jankovic Ivana , Konigstein Maayan , Lustre Mitchel B. , Peralta Yolayfi , Sanchez Raquel , Min James , Arsanjani Reza , Budoff Matthew , Elmore Kimberly , Gomez Millie , Hague Cameron , Hindoyan Niree , Leipsic Jonathan , Nakanishi Rine , Srichai-Parsia M. Barbara , Yeoh Eunice , Youn Tricia , Maggioni Aldo P. , Bianchini Francesca , Ceseri Martina , Lorimer Andrea , Magnoni Marco , Orso Francesco , Sarti Laura , Tricoli Martinia , Carvalho Antonio , Lopes Renato , Barbosa Lilian Mazza , Duarte Tauane Bello , Soares Tamara Colaiácovo , Aveiro Morata Julia de , Carvalho Pedro , Carvalho Maffei Natalia de , Egydio Flávia , Kawakami Anelise , Oliveira Janaina , Piloto Elissa Restelli , Pozzibon Jaqueline , Goodman Shaun , Camara Diane , Mowafy Neamat , Spindler Caroline , Jiang Lixin , Dai Hao , Feng Fang , Li Jia , Li Li , Liu Jiamin , Xie Qiulan , Zhang Haibo , Zhang Jianxin , Zhang Lihua , Zhang Liping , Zhang Ning , Zhong Hui , Diaz Rafael , Escobar Claudia , Martin Maria Eugenia , Pascual Andrea , Lopez-Sendon José , Moraga Paloma , Hernandez Victoria , Castro Almudena , Posada Maria , Fernandez Sara , Villanueva José Luis Narro , Selgas Rafael , Steg Gabriel , Abergel Helene , Juliard Jean Michel , White Harvey , Alsweiler Caroline , de Werf Frans Van , Claes Kathleen , Goetschalckx Kaatje , Luyten Ann , Robesyn Valerie , Selvanayagam Joseph B. , Murphy Deirdre , Ahmed Asker , Bhatt Richa , Chadha Nitika , Kumar Vijay , Lubna Sadath , Naik Pushpa , Pandey Shruti , Ramasamy Karthik , Saleem Mohammed , Sharma Pratiksha , Siddaram Hemalata 
Published: April 2024

BACKGROUND:

ISCHEMIA (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) did not find an overall reduction in cardiovascular events with an initial invasive versus conservative management strategy in chronic coronary disease; however, there were conservative strategy participants who underwent invasive coronary angiography early postrandomization (within 6 months). Identifying factors associated with angiography in conservative strategy participants will inform clinical decision-making in patients with chronic coronary disease.

METHODS:

Factors independently associated with angiography performed within 6 months of randomization were identified using Fine and Gray proportional subdistribution hazard models, including demographics, region of randomization, medical history, risk factor control, symptoms, ischemia severity, coronary anatomy based on protocol-mandated coronary computed tomography angiography, and medication use.

RESULTS:

Among 2591 conservative strategy participants, angiography within 6 months of randomization occurred in 8.7% (4.7% for a suspected primary end point event, 1.6% for persistent symptoms, and 2.6% due to protocol nonadherence) and was associated with the following baseline characteristics: enrollment in Europe versus Asia (hazard ratio [HR], 1.81 [95% CI, 1.14–2.86]), daily and weekly versus no angina (HR, 5.97 [95% CI, 2.78–12.86] and 2.63 [95% CI, 1.51–4.58], respectively), poor to fair versus good to excellent health status (HR, 2.02 [95% CI, 1.23–3.32]) assessed with Seattle Angina Questionnaire, and new/more frequent angina prerandomization (HR, 1.80 [95% CI, 1.34–2.40]). Baseline low-density lipoprotein cholesterol <70 mg/dL was associated with a lower risk of angiography (HR, 0.65 [95% CI, 0.46–0.91) but not baseline ischemia severity nor the presence of multivessel or proximal left anterior descending artery stenosis >70% on coronary computed tomography angiography.

CONCLUSIONS:

Among ISCHEMIA participants randomized to the conservative strategy, angiography within 6 months of randomization was performed in <10% of patients. It was associated with frequent or increasing baseline angina and poor quality of life but not with objective markers of disease severity. Well-controlled baseline low-density lipoprotein cholesterol was associated with a reduced likelihood of angiography. These findings point to the importance of a comprehensive assessment of symptoms and a review of guideline-directed medical therapy goals when deciding the initial treatment strategy for chronic coronary disease.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01471522.