bluuebunny/crossref_metadata_2025 huggingface dataset:
Calibration-free heterodyne phase-sensitive dispersion spectroscopy: quantitative gas sensing and recovery of absorption spectra
Authors: Ma Liuhao , Zhou Chen , Wang Zhen , Ren Wei , Wang Yu
Published: September 2024

Heterodyne phase-sensitive dispersion spectroscopy (HPSDS) is a quantitative non-intrusive gas sensing technique based on the determination of the refractive index of the target gas in the vicinity of an absorption transition. Since the phase instead of the intensity of the probing laser light is targeted, the technique boasts the advantage of being normalization-free. It is thus largely immune to laser intensity fluctuations due to either system instability or ambient interferences. Previous HPSDS-based sensors typically require calibration using standard mixtures to establish a look-up table between the measured phase signal and gas concentrations, which is both cumbersome and problematic when there are significant compositional variations between the calibration standards and the target gas. In this work, we present a robust and generic technique that addresses this issue with a successful realization of fully calibration-free measurements. Spectral-fitting to the entire dispersion spectra with free variables related to transition linecenter, broadening width, and integrated absorbance were used to eliminate the effects of unknown spectral broadening coefficients. What we believe to be a novel analytical model was proposed to unify both direct injection-current dithering-based HPSDS that includes simultaneous frequency/intensity modulation, and the external electro-optic modulator (EOM) modulation-based HPSDS with a non-ideal linear response of EOM. The proposed technique was first validated via numerical experiment to determine the gas concentration and the recovery of the absorption profiles. Actual experiments were subsequently performed for the measurement of CH4 near 1.65 µm, N2O near 4.46 µm, and NO near 5.26 µm, collectively demonstrating the capability of the technique for both near- and mid-infrared lasers with diverse modulation characteristics. Further demonstrations were performed to measure NH3 concentrations at elevated temperatures through the fitting of the multiple dispersion spectra near 9.06 µm. The robust iterative spectral-fitting strategy and the measurement accuracies confirm the robustness of the proposed calibration-free (CF) HPSDS technique for quantitative gas sensing.
Watt-level single-frequency optical parametric oscillator around 2 µm
Authors: Coluccelli N. , Cichelli G. , Polastri M. , Gambetta A. , Galzerano G. , Laporta P.
Published: September 2024

A single-frequency optical parametric oscillator (OPO) operating in the wavelength range around 2 µm is reported. The OPO comprises a periodically poled LiNbO3 (PPLN) crystal for quasi-phase matching and a four-mirror ring-cavity resonant to the signal. The OPO signal and idler are tuned from 1.89 to 2.05 µm and from 2.21 to 2.42 µm, respectively, by changing the crystal temperature. Output powers in excess of 2 W are demonstrated at a pump power of 9 W for both the signal and idler over all of the respective tuning ranges. A detailed characterization of the intensity and frequency noise is presented. The OPO exhibits an integrated intensity noise below 0.1% and a linewidth of ∼58 kHz for an observation time of 1 ms. The reported performance makes this source an ideal candidate for the generation of squeezed light around 2 µm via cascaded second-harmonic generation (SHG) and parametric downconversion (PDC).
Changes in DNA methylation contribute to rapid adaptation in bacterial plant pathogen evolution
Authors: Gopalan-Nair Rekha , Coissac Aurore , Legrand Ludovic , Lopez-Roques Céline , Pécrix Yann , Vandecasteele Céline , Bouchez Olivier , Barlet Xavier , Lanois Anne , Givaudan Alain , Brillard Julien , Genin Stéphane , Guidot Alice
Published: September 2024

Adaptation is usually explained by beneficial genetic mutations that are transmitted from parents to offspring and become fixed in the adapted population. However, genetic mutation analysis alone is not sufficient to fully explain the adaptive processes, and several studies report the existence of nongenetic (or epigenetic) inheritance that can enable adaptation to new environments. In the present work, we tested the hypothesis of the role of DNA methylation, a form of epigenetic modification, in adaptation of the plant pathogen Ralstonia pseudosolanacearum to the host during experimental evolution. Using SMRT-seq technology, we analyzed the methylomes of 31 experimentally evolved clones obtained after serial passages on 5 different plant species during 300 generations. Comparison with the methylome of the ancestral clone revealed a list of 50 differential methylated sites (DMSs) at the GTWWAC motif. Gene expression analysis of the 39 genes targeted by these DMSs revealed limited correlation between differential methylation and differential expression of the corresponding genes. Only 1 gene showed a correlation, the RSp0338 gene encoding the EpsR regulator protein. The MSRE-qPCR technology, used as an alternative approach for DNA methylation analysis, also found the 2 DMSs upstream RSp0338. Using site-directed mutagenesis, we demonstrated the contribution of these 2 DMSs in host adaptation. As these DMSs appeared very early in the experimental evolution, we hypothesize that such fast epigenetic changes can allow rapid adaptation to the plant stem environment. In addition, we found that the change in DNA methylation upstream RSp0338 remains stable at least for 100 generations outside the host and thus can contribute to long-term adaptation to the host plant. To our knowledge, this is the first study showing a direct link between bacterial epigenetic variation and adaptation to a new environment.
A comparative study of influenza surveillance systems and administrative data in England during the 2022–2023 season
Authors: Mellor Jonathon , Christie Rachel , Guilder James , Paton Robert S. , Elgohari Suzanne , Watson Conall , Deeny Sarah R. , Ward Thomas
Published: September 2024

Accurate and representative surveillance is essential for understanding the impact of influenza on healthcare systems. During the 2022–2023 influenza season, the Northern Hemisphere experienced its most significant epidemic wave since the onset of the COVID-19 pandemic in 2020. Concurrently, new surveillance systems, developed in response to the pandemic, became available within health services. In this study, we analysed per capita admission rates from National Health Service hospital Trusts across four surveillance systems in England during the winter of 2022–2023. We examined differences in reporting timeliness, data completeness, and regional coverage, modelling key epidemic metrics including the maximum admission rates, cumulative seasonal admissions, and growth rates by fitting generalised additive models at national and regional levels. From modelling the admission rates per capita, we find that different surveillance systems yield varying estimates of key epidemiological metrics, both spatially and temporally. While national data from these systems generally align on the maximum admission rate and growth trends, discrepancies emerge at the subnational level, particularly in the cumulative admission rate estimates, with notable issues observed in London and the East of England. The rapid growth and decay phases of the epidemic contributed to higher uncertainty in these estimates, especially in regions with variable data quality. The study highlights that the choice of surveillance system can significantly influence the interpretation of influenza trends, especially at the subnational level, where regional disparities may mask true epidemic dynamics. Comparing multiple data sources enhances our understanding of the impact of seasonal influenza epidemics and highlights the limitations of relying on a single system.
Perceived ease of use of Truenat among laboratory staff as a new diagnostic tool for TB in Nigeria: Result of a pilot roll-out
Authors: Ihesie Austin , Nwokoye Nkiru , Olabamiji Jamiu , Ochei Kingsley , Eneogu Rupert , Nongo Debby , Babayi Aminu , Olugbemiga Rayi , Odume Bethrand , Agbaje Aderonke , Oyelaran Omosalewa , van Germert Wayne , Mupfumi Lucy , Amos Omoniyi , Emeka Elom , Anyaike Chukwuma , Ossai Edmund Ndudi
Published: September 2024

In January 2020, WHO released a rapid communication on use of molecular assays as initial tests for diagnosis of tuberculosis, recommending Truenat as a replacement for smear microscopy in TB diagnosis. This study was designed to assess perceived ease of use of Truenat among Laboratory staff as a new diagnostic tool for TB in Nigeria. This study used a cross-sectional design. All trained Laboratory personnel operating the Truenat Duo equipment in 38 Truenat sites in the country were included. Information was obtained using a pre-tested self-administered questionnaire. Ease of use of Truenat was assessed using twenty-three variables on a five-point Likert scale of 1–5. The variables were analyzed quantitatively and qualitatively. Good Ease of use of Truenat was determined by proportion of respondents who answered ≥70% of the variables in the positive. All 50 Truenat Laboratory staff participated in the study. (Response rate 100%). Majority, (58%) were male. The median estimated number of tests before Laboratory staff became proficient with Truenat machine was 9 (IQR, 4–20), median number of tests to be analyzed within eight working hours was 10, (IQR = 8–15) and median time to conduct a Truelab MTBPlus test from start to finish was 60 minutes (IQR = 60–80). The commonest operational challenge that required Molbio service support was Trueprep errors/blockage, 47.4%. Overall, mean ease of use score was 4.0±0.4. Majority, (76%) had Good Ease of use of Truenat. No factor significantly influenced Ease of use of Truenat. Truenat machine is easy to use for a trained laboratory staff with minimal technical support and hence could be rolled out easily and successfully by various National TB Programs. Considering the high Trueprep challenges reported, there is need for further studies into the common errors/challenges, the contexts surrounding them and the programmatic intervention to address the high rate of Trueprep equipment faults.
A cross-sectional assessment of expanding basic healthcare services to rural and underserved communities through proprietary patent medicine vendors in Northern Nigeria
Authors: Ibitoye John Oluwasegun , Asaolu Olugbenga , Amao Adebayo , Obembe Oluwagbemiga , Ijaya Mukhtar A. , Obanubi Christopher , Adeniran Adeniyi , Bello Mustapha , Asaolu Olutayo , Alawode Gbadegesin , Uwalaka Chiamaka , Ojelade Olubunmi , Emeka Chisom , Onimode Bayo , Asaolu Olubayode , Ojewumi Titus , Nalda Nannim , Oyeyemi Olubusola , Abubakar Abdulmalik , Nwadike Chukwuka , Ugwu Adaeze
Published: September 2024

The poor health indices in Nigeria are widely reported to be fueled by an acute shortage of skilled medical personnel. Opinions are converging that Proprietary and Patent Medicine Vendors (PPMVs) can bridge this human resource for health gaps. This study therefore aimed to assess the acceptability, appropriateness, and feasibility of providing expanded basic health services among the skilled health workers operating PPMVs in underserved communities in Northern Nigeria states. This is a cross-sectional study of all the 220 PPMVs operated by skilled health workers in underserved communities of six randomly selected Local Government Areas in Jigawa state) and Kaduna State from July to October 2022). Statistical significance was determined at P<0.05. Of the 220 respondents surveyed, 77% are males; the median age was 33 years (IQR = 9). More than half (52.3%) were community health extension workers, and 16.4% are nurses/midwives. The median scores (with IQR) for Acceptability, Appropriateness, and Feasibility were 18 (16), 17 (15), and 17 (15), respectively. We reported that PPMVs of tribes other than Hausa, Fulani or Kanuri; operating their shops in the evening or morning or possessed positive behavioral control expressed lower acceptability (P< 0.05). Operating in Kaduna State and perceived negative behavioral control were significantly associated with lower appropriateness measure(P<0.01). PPMVs operating below 24 hours had higher appropriateness (P<0.01). PPMVs operating below 24 hours and perceived negative behavioral control had lower feasibility scores. Our Study findings suggests that there is significant potential for medically trained PPMVs operating in underserved communities in Northern Nigeria to contribute to bridging the gap in access to basic health services in hard-to-reach areas.
Social validity of acceptance-based workplace mental health training for use in a low resource setting. A qualitative study with Ugandan mental health providers
Authors: Musanje Khamisi , Flaxman Paul E. , McIntosh Ross , Kasujja Rosco
Published: September 2024

In low-resource settings, working age adults suffer a disproportionately higher mental health burden due to precarious work environments; yet access to evidence-based worksite mental health promotion programs remains severely limited due to the lack of professional service providers. Alternative mental wellness programs that are affordable, accessible and help build resilience to deal with the daily demands of work and life need to be introduced in workplaces of low-resource contexts. Such programs should however be acceptable and of social importance to the targeted contexts. Acceptance-based approaches meet these criteria but have mainly been implemented and evaluated in high-income countries. Gauging the appropriateness of such programs for low-resource workplace settings before wide-scale implementation is necessary. We engaged n = 14 mental health providers living and working in Kampala-Uganda in a one-day workshop focused on using acceptance and commitment training in the workplace. During in-depth interviews, these providers shared feedback on the social importance of the program’s goals and effects, and acceptability of the program’s procedures to Ugandan society. A deductive thematic approach was used to analyze data (codes organized according to a priori thematic categories that aligned with the Social Validity Framework). Findings showed that the program’s goals and effects were gauged as socially significant and the training process was acceptable. However, key adjustments were recommended, including introducing communal values into the program, reducing session load, integrating mental health awareness strategies, and adding contextually relevant metaphors. These adjustments are likely to enhance the appropriateness of this type of acceptance-based worksite mental health promotion program for use in Uganda.
Revisiting the impact of Schistosoma mansoni regulating mechanisms on transmission dynamics using SchiSTOP, a novel modelling framework
Authors: Malizia Veronica , de Vlas Sake J. , Roes Kit C. B. , Giardina Federica
Published: September 2024

Background

The transmission cycle of Schistosoma is remarkably complex, including sexual reproduction in human hosts and asexual reproduction in the intermediate host (freshwater snails). Patterns of rapid recrudescence after treatment and stable low transmission are often observed, hampering the achievement of control targets. Current mathematical models commonly assume regulation of transmission to occur at worm level through density-dependent egg production. However, conclusive evidence on this regulating mechanism is weak, especially for S. mansoni. In this study, we explore the interplay of different regulating mechanisms and their ability to explain observed patterns in S. mansoni epidemiology.

Methodology/Principal findings

We developed SchiSTOP: a hybrid stochastic agent-based and deterministic modelling framework for S. mansoni transmission in an age-structured human population. We implemented different models with regulating mechanisms at: i) worm-level (density-dependent egg production), ii) human-level (anti-reinfection immunity), and iii) snail-level (density-dependent snail dynamics). Additionally, we considered two functional choices for the age-specific relative exposure to infection. We assessed the ability of each model to reproduce observed epidemiological patterns pre- and post-control, and compared successful models in their predictions of the impact of school-based and community-wide treatment.

Simulations confirmed that assuming at least one regulating mechanism is required to reproduce a stable endemic equilibrium. Snail-level regulation was necessary to explain stable low transmission, while models combining snail- and human-level regulation with an age-exposure function informed with water contact data were successful in reproducing a rapid rebound after treatment. However, the predicted probability of reaching the control targets varied largely across models.

Conclusions/Significance

The choice of regulating mechanisms in schistosomiasis modelling largely determines the expected impact of control interventions. Overall, this work suggests that reaching the control targets solely through mass drug administration may be more challenging than currently thought. We highlight the importance of regulating mechanisms to be included in transmission models used for policy.
Water extract of ginseng alleviates parkinsonism in MPTP–induced Parkinson’s disease mice
Authors: Xu Ning , Xing Shuyang , Li Jie , Pang Bo , Liu Meichen , Fan Meiling , Zhao Yu
Published: September 2024

In this study, we investigated the neuroprotective effect of a water extract of ginseng (WEG) obtained via low–temperature extraction of the brain of mice with Parkinson’s disease (PD) and the ameliorative effect on the damaged intestinal system for the treatment of dyskinesia in PD mice. MPTP (1–methyl–4–phenyl–1,2,3,6–tetrahydropyridine) was injected intraperitoneally into male C57BL/6 mice to establish a PD model, and WEG was given via oral gavage. The results indicated that WEG could protect the damaged neuronal cells of the mice brain, inhibit the aggregation of α-synuclein (α–Syn) in the brain, and increase the positive expression rate of tyrosine hydroxylase (TH). WEG significantly improved intestinal damage and regulated intestinal disorders (P<0.05). WEG intervention increased the levels of beneficial bacteria, such as Lactobacillus, and normalized the abundance and diversity of colonies in the intestine of mice. Our results suggested that WEG protected neurons in the brain of PD mice via inhibiting the aggregation of α–Syn in the brain and increasing the positive expression level of TH in the brain. WEG regulated the gut microbiota of mice, improved the behavioral disorders of PD mice, and offered some therapeutic effects on PD mice.
Knowledge and perceptions of snakes, snakebites and their management among health care workers in Sudan
Authors: Saeed Ali Awadallah , Gibreel Omer A. , B. Mousa Ayman , Omer Saeed M. , Omer Abdallateif Alkhair , A. M. A. Elalawy Intisar , Hassan Fahal Ahmed
Published: September 2024

Background

Snakebite statistics in Sudan are lacking despite the high estimated burden of the problem. One study in Sudan reported the presence of 17 medically significant snakes belonging to three major families: Burrowing asps, Elapidae, and Viperidae. These snakes usually become abundant during and after the rainy season, and most snakebite victims are farm workers. This study was set out based on the observed snakebite management, poor outcomes and lack of information on the healthcare provider’s knowledge of this serious, deadly medical and health condition in snakebite-endemic regions of Sudan.

Materials and methods

In August 2022, a descriptive cross-sectional survey was conducted involving 394 medical and healthcare providers in snakebite-endemic regions of Sudan (Gaddarif, Sinnar, Khartoum, and Kassala). A validated questionnaire was used. It consisted of seven sections addressing the study population demographic characteristics, knowledge of snakes, snakebites, and their management. Data analysis used various statistical tests using Microsoft Excel and the Statistical Package for Social Sciences (SPSS) version 20 (IBM SPSS Inc., Chicago, IL) was done.

Results

Among the 394 participants (44.7% males, 53.3% females), 58.1% demonstrated adequate knowledge of snakes, and 45.3% exhibited adequate knowledge of snakebites. A mere 25.9% received training in snakebite management, with 60.4% possessing adequate knowledge in this domain. Only 14% expressed high confidence in managing snakebites, and 40.9% reported having protocols for snakebite management at their health facilities.

Conclusion

The study highlighted the inadequacy of healthcare providers’ knowledge in snakebite-endemic areas in Sudan regarding snakes, snakebites and snakebites management. Urgent interventions, such as intensive continuing professional education and training, are essential to address this neglected medical and health problem.
Factors associated with postoperative visual function after rhegmatogenous retinal detachment with foveal detachment
Authors: Sugioka Yuki , Yokoyama Sho , Mori Toshio , Matsuda Taisuke , Kaga Tatsushi
Published: September 2024

Purpose

To investigate pre-, intra-, and postoperative factors influencing postoperative visual acuity, degree of metamorphopsia, and retinal sensitivity after vitrectomy in patients with rhegmatogenous retinal detachment and foveal detachment.

Methods

We reviewed retrospectively 33 consecutive eyes of 32 patients, who underwent vitrectomy for rhegmatogenous retinal detachment with foveal detachment between August 2018 and October 2020 and obtained retinal reattachment. Pre-, intra-, and postoperative characteristics were comprehensively analyzed using multivariate models to evaluate the presence of factors influencing best-corrected visual acuity, vertical/horizontal metamorphopsia scores using M-CHARTS (Inami & Co., Ltd., Tokyo, Japan), and retinal sensitivity using the MP-3 (NIDEK Co., Aichi, Japan) at 1-year postoperatively.

Results

Preoperative total retinal detachment was the only factor significantly associated with worse best-corrected visual acuity at 1-year postoperatively (β = 0.589, P<0.001). Intraoperative internal limiting membrane peeling (β = 0.443, P = 0.003) and longer duration after recognizing visual dysfunction (β = 0.425, P = 0.005) were significantly associated with higher vertical metamorphopsia scores at 1 year. The horizontal metamorphopsia score was significantly related to the duration after recognizing visual dysfunction (β = 0.457, P = 0.008). The disappearance of the EZ line on optical coherence tomography at 3 months postoperatively (β = −0.638, P<0.001) was significantly associated with lower retinal sensitivity at 1 year.

Conclusions

Our study findings suggest that best-corrected visual acuity, metamorphopsia, and retinal sensitivity at 1 year after vitrectomy for rhegmatogenous retinal detachment with foveal detachment are influenced by distinct factors.
Non-pharmacological delirium detection and management interventions for informal caregivers of older people at home: A scoping review protocol
Authors: Fox Mary T. , Maimets Ilo-Katryn , Butler Jeffrey I. , Sidani Souraya , Godfrey Christina
Published: September 2024

Objective

The objective of this proposed scoping review is to identify and map the available evidence on interventions that aim to help informal caregivers identify and/or manage delirium in an older person at home.

Introduction

Delirium is a neurocognitive condition characterized by acute confusion and is associated with increased risk of morbidity and mortality. Research estimates delirium to be present in 17% of community-dwellers aged 85 and older, increasing proportionally with age to 45% in those aged 90 and older. Delirium often occurs at the onset of an older person’s acute illness or exacerbation of a chronic illness (sometimes while at home) and, because of its protracted nature, usually continues after a hospital stay. Even when an older person’s delirium resolves during hospitalization, they remain at risk of its recurrence after discharge home. Consequently, knowing how to detect and manage delirium is critical for informal caregivers of older people at home. However, there are no reviews focused exclusively on this topic in this setting.

Inclusion criteria

The population of interest includes informal caregivers of a person aged 65+. Concepts of interest include delirium detection and/or management interventions. The context of interest is any setting where informal care is delivered, including the transition from hospital to home, in any geographical area.

Materials and methods

The review will be conducted according to the JBI guidelines for scoping reviews. A three-step search strategy will be used to locate both published and unpublished papers in MEDLINE, Embase, CINAHL, PsycINFO, Web of Science Core Collection, ProQuest Nursing & Allied Health, SCOPUS, LILACS, and SciELO, PQD&T, NDLTD, Google Scholar and Google. No language restrictions will be placed on the review. Papers will be screened for eligibility at the title, abstract, and full text level by two independent reviewers. Data will be extracted by two independent reviewers and managed in Covidence. Any disagreements in screening or data extraction will be resolved by consensus or a third reviewer. Results will be summarised in narrative and tabular formats.
More precise method of low-density lipoprotein cholesterol estimation for tobacco and electronic cigarette smokers: A cross-sectional study
Authors: Bae Han-Joon , Jung Hae Won , Hong Seung-Pyo
Published: September 2024

Smoking is associated with elevated low-density lipoprotein cholesterol (LDL-C) levels. However, the accuracies of the Friedewald, Sampson, and Martin LDL-C-estimating equations based on smoking status are unclear. We analyzed the accuracy of LDL-C levels estimated using these three equations based on tobacco and electronic cigarette smoking status. Data on LDL-C and other lipid components were obtained from the Korea National Health and Nutrition Examination Survey from January 2009 to December 2021. Direct LDL-C (dLDL-C) levels and smoking data of 12,325 participants were evaluated. Current smokers had higher triglyceride levels than never smokers. Electronic cigarette smokers had higher triglyceride and dLDL-C levels than never smokers. The Martin equation yielded more accurate mean absolute deviations than the other equations for the group with triglyceride levels <400 mg/dL as well as more accurate median absolute deviation values, except for the group with dLDL-C levels <40 mg/dL. Similar estimates were derived from the equations when the triglyceride levels were <150 mg/dL. However, the Martin equation may lead to the overestimation of LDL-C levels. In conclusion, the Martin equation is suitable for triglyceride levels <400 mg/dL regardless of the electronic cigarette/tobacco smoking status; if the triglyceride level is <150 mg, the Friedewald equation could also be considered, regardless of the electronic cigarette/tobacco smoking status.
Promoting positive youth development in rural communities: Integrating social work, psychology, and education
Authors: Ren Jiawei
Published: September 2024

Considering the peculiar socio-cultural background and developmental obstacles encountered by rural youth in China, the study examines the necessity of adopting an integrated strategy that brings together social work, psychology, and education to promote positive youth development. This research intends to fill the gap by explaining the impact of these factors on community engagement and youth development in China. Targeted programs were also suggested according to the needs of rural youth in China. The respondents of the study comprised 350 young people, whose age ranged from 15 to 24 years, living in different rural areas of the country. The structured questionnaire was designed to collect the data using a convenience sampling technique. Structural Equation Modeling (SEM) was applied as the analysis tool using IBM SPSS AMOS software. The results show that social work and education have a significant impact on community engagement and positive youth development. The findings also reveal that psychology positively influences community engagement. Community engagement was seen to mediate the relationships between social work, psychology, education, and positive youth development. The policymakers and practitioners can fully use the interrelationships between social work, psychology, and education to create a more comprehensive approach that considers the specific characteristics of rural youth in China. Additionally, highlighting community engagement as a mediator also explores the opportunity for bottom-up initiatives and community efforts to instigate favorable youth outcomes in the countryside.
Robotic dog for navigation of a rehabilitation wheelchair robot in a highly constrained environment
Authors: Sharma Bibhya
Published: September 2024

Adaptation to technological advancements and intelligent digital tools can enable healthcare providers to overcome the challenges of their patient-oriented care systems and processes. One such intelligent tool is automated assistive robots, which can improve patient care and safety in the health sector. This paper presents an invariant set of continuous nonlinear control laws for an assistive robot and a rehabilitation wheelchair robot modeled as a new autonomous robotic dog and rehabilitation wheelchair system for navigating a highly constrained environment. The control laws are derived from the Lyapunov-based control scheme classified under the umbrella of artificial potential field (APF) methods, and inherently proved stability of the new heterogeneous system. The robotic dog guides the wheelchair robot during the navigation process in a cluttered environment where the avoidances are from the robotic dog and the integrated dynamic protective polygon. The wheelchair traverses the obstacle-free path traced by the dynamic polygon. The leash is flexible, and its length is bounded, which invariably provides the protective polygon to change its intrinsic dimension. Thus, the dual-robot system has increased mobility for obstacle avoidance and passing through narrow passageways. The solution proffered herein is only feasible in a highly constrained and isolated human environment where nothing else appears to be moving in the direction of the robotic dog and wheelchair. The computer simulations and associated convergence graphs present the efficacy of the unique control laws for the new heterogeneous robotic system. Adoption of such control laws and their suitable variants can make a big impact in the healthcare industry.
Morphological multiparameter filtration and persistent homology in mitochondrial image analysis
Authors: Chung Yu-Min , Hu Chuan-Shen , Sun Emily , Tseng Henry C.
Published: September 2024

The complexity of branching and curvilinear morphology of a complete mitochondrial network within each cell is challenging to analyze and quantify. To address this challenge, we developed an image analysis technique using persistent homology with a multiparameter filtration framework, combining image processing techniques in mathematical morphology. We show that such filtrations contain both topological and geometric information about complex cellular organelle structures, which allows a software program to extract meaningful features. Using this information, we also develop a connectivity index that describes the morphology of the branching patterns. As proof of concept, we utilize this approach to study how mitochondrial networks are altered by genetic changes in the Optineurin gene. Mutations in the autophagy gene Optineurin (OPTN) are associated with primary open-angle glaucoma (POAG), amyotrophic lateral sclerosis (ALS), and Paget’s disease of the bone, but the pathophysiological mechanism is unclear. We utilized the proposed mathematical morphology-based multiparameter filtration and persistent homology approach to analyze and quantitatively compare how changes in the OPTN gene alter mitochondrial structures from their normal interconnected, tubular morphology into scattered, fragmented pieces.
Landscape and female fertility evaluation of seven heavenly bamboo cultivars as potential non-invasive alternatives to the wildtype
Authors: Rycyna Julia , Wilson Sandra , Deng Zhanao , Iannone Basil , Knox Gary
Published: September 2024

In recent years, breeding initiatives have been made to reduce the fecundity of invasive plants leading to sterile cultivars. The wildtype form of heavenly bamboo (Nandina domestica Thunb. (Berberidaceae) and seven cultivars were evaluated for landscape performance, fruit production and seed viability at three sites in Florida located in southwest, northcentral, and north Florida. For heavenly bamboo cultivars in north Florida, ‘Emerald Sea’, ‘Greray’ (Sunray®), ‘Lemon-Lime’, ‘Murasaki’ (Flirt™), ‘SEIKA’ (Obsession™), and ‘Twilight’ performed well throughout much of the study with average visual quality ratings between 3.54 and 4.60 (scale of 1 to 5). In northcentral Florida heavenly bamboo cultivars are ‘Emerald Sea’, ‘Greray’, ‘Lemon-Lime’, ‘Murasaki’, ‘SEIKA’, and ‘Twilight’ performed well throughout much of the study with average quality ratings between 4.49 and 4.94. In southwest Florida, ‘Emerald Sea’, ‘Greray’, ‘Lemon-Lime’, ‘Murasaki’, and ‘SEIKA’ performed well with average quality ratings between 3.40 and 4.83. At all three sites, ‘Emerald Sea’ and the wildtype were similar in size, having the greatest growth indices compared to medium-sized cultivars (‘Greray’, ‘Lemon-Lime’, ‘Twilight’ and ‘SEIKA’) and dwarf-sized cultivars (‘Chime’ and ‘Murasaki’). For three consecutive fall-winter seasons of the study, ‘Chime’, ‘Greray’, and ‘Lemon-Lime’ heavenly bamboo did not fruit at any of the study sites. Among the three sites, ‘Murasaki’ had 97.7% to 99.9% fruit reduction, ‘SEIKA’ had 97.7% to 100% fruit reduction, and ‘Twilight’ had 95.9% to 100% fruit reduction compared to the wildtype at respective sites. Seeds collected from low fruiting cultivars (‘Murasaki’, ‘SEIKA’, and ‘Twilight’) had 33.3% to 66.7% viability, as determined by tetrazolium tests. In comparison, ‘Emerald Sea’ produced as much, if not more, fruit as the wildtype, especially in northern Florida, with seed viability ranging from 6.7% to 29.0% among sites. Nuclear DNA content of cultivars were comparable to the wildtype, suggesting they are diploids. These findings identified four low to no fruiting heavenly bamboo cultivars recommended for landscape use (‘Lemon-Lime’, ‘SEIKA’, ‘Murasaki’, and ‘Greray’).
Scaffolding learning: From specific to generic with large language models
Authors: Yin David S. , Yin Xiaoxin
Published: September 2024

Large language models such as ChatGPT have been shown to excel in solving complex math problems. However, they cannot solve basic arithmetic problems such as 758*639 = 484,362. This makes us ponder if LLMs have been trained to solve math and science problems in the right way. When a student learns math at school, she or he starts with arithmetic, then moves to word problems, polynomials, and calculus. Each skill she or he acquires will be used in the next stage to solve more advanced problems. In this paper we propose Scaffolding Learning for LLMs, which imitates how a student learns a subject in a step-by-step manner. For example, we first train an LLM to perform highly specific operations such as multiplication and division, and then apply such “skills” in a more generic task such as solving word problems. This is related to Curriculum Training, which trains a model on tasks following a specific order, such as training on easy tasks first and then gradually increases the difficulty. Our proposed approach goes from specific tasks to generic ones, which can be considered as a special case of Curriculum Training. Our empirical studies show that when an LLM has “mastered” a specific skill, only a small amount of training is required to teach it to apply the skill to a more generic application.
Explore an open-source value co-creation framework: A multiple case study
Authors: Luo Yang , Jin Yongsheng , Ji Yuanmao
Published: September 2024

Open-source communities(OSCs) are gaining significant attention in the current business environment of information technology(IT). More and more IT companies and individuals are exploring how to achieve innovation through open-source collaboration, and value co-creation(VCC) in the OSCs has become a trend. Therefore, it is particularly important to examine the mechanism of OSCs under the background of VCC theory. This study proposes a conceptual framework of open-source value co-creation (OSVCC), which is characterized by openness, sharing, collaboration, and freedom, for understanding the internal mechanisms and contextual conditions in the relationship between OSCs participants. This study constructed a pairwise combined four-category classification model combining the perspectives of the commercialization level (low and high) and the maturity stage (developmental and mature) of the OSCs. Based on the model, this study selects and analyzes four presentive cases of OSCs using a multiple case study approach. Then, this study proposes a framework for OSVCC to identify the crucial factors that promote the successful implementation of innovation and value creation. The OSVCC framework encompasses three primary participants, effective VCC processes, and key open-source principles. This study offers valuable managerial implications for enterprises that plan to participate in OSCs.
Income insecurity and social protection: Examining the impact of the COVID-19 pandemic across income groups
Authors: Chen Na
Published: September 2024

The COVID-19 pandemic has wrought unprecedented disruption on global economies, leading to widespread income insecurity among individuals and households. This study investigates the impact of the pandemic on income insecurity across different income groups and assesses the role of social protection measures in mitigating these effects. Using cross-country data, we analyze the prevalence of income reduction and the effectiveness of social assistance programs in high-income, upper middle-income, lower middle-income, and low-income countries. Our findings reveal significant variations in income insecurity and social protection responses across these groups. the pandemic had a significant impact on household incomes globally, with lower-middle-income countries experiencing the most significant income reductions. The average per capita transfer amounts show a general decrease over time, which could be due to the economic strain on governments and the need for more sustainable social protection programs. The correlation between transfer amounts and the proportion of households with reduced income indicates that countries with higher income reduction rates tended to have lower average per capita transfer amounts, suggesting a potential lack of adequate support for those in need. The study highlights the importance of robust social safety nets in cushioning the economic blow of the pandemic, particularly for vulnerable populations in lower-income countries.
Comparative study of the McGrath™ videolaryngoscope blades and conventional laryngoscopy efficacy during mechanical chest compressions: Insights from a randomized trial with 90 anesthesiologists on objective and subjective parameters
Authors: Golditz Tobias , Schmidt Joachim , Birkholz Torsten , Danzl Anja , Moritz Andreas , Ackermann Andreas , Irouschek Andrea
Published: September 2024

Aims

This study aimed to compare the efficacy and utility of the McGrath™ videolaryngoscope, using the Macintosh-like McGrath™ MAC blade and the hyperangulated McGrath™ MAC Xblade with a conventional Macintosh blade under simulated resuscitation conditions.

Methods

A prospective, randomized study under conditions mimicking ongoing chest compressions was conducted with 90 anesthesiologists. Intubation success rates, time-to-vocal cords, time-to-intubate, and time-to-ventilate were measured. Additionally, the study assessed the subjective ratings and the perceived workload using the ‘NASA-task-load-index’ during the procedure.

Results

The overall intubation success rate was device dependent 99–100%. The McGrath™ MAC and McGrath™ MAC Xblade showed faster visualization times compared to conventional blades. The MAC blade demonstrated superior performance in time-to-intubate and time-to-ventilate compared to both conventional and MAC Xblades. Despite excellent visualization, the MAC Xblade posed challenges in tube placement, reflected in a prolonged intubation time of >120 seconds in one case. Both MAC and MAC Xblade reduced potential dental injuries and interruptions to chest compressions compared to conventional laryngoscopes. User experience significantly impacted intubation times with conventional laryngoscopes, but this effect was mitigated with videolaryngoscopy. Participants reported lower stress and effort when using videolaryngoscopes, with the MAC blade rated superior in perceived time pressure.

Conclusion

The study supports the superiority of videolaryngoscopy with a Macintosh-like blade over conventional laryngoscopy during mechanical chest compressions, particularly for less experienced users. The McGrath™ MAC blade, in particular, offers advantages in intubation time, user-friendliness, and reduced stress. However, the MAC Xblade’s challenges during tube placement highlight the need for further clinical validation. Continued research is essential to refine guidelines and improve resuscitation outcomes.
DBDAA: A real-time approach to Dynamic Banker’s Deadlock Avoidance Algorithm with optimized time complexity
Authors: Zohora Most. Fatematuz , Farhin Fahiba , Kaiser M. Shamim
Published: September 2024

Effective resource allocation is crucial in operating systems to prevent deadlocks, especially when resources are limited and non-shareable. Traditional methods like the Banker’s algorithm provide solutions but suffer from limitations such as static process handling, high time complexity, and a lack of real-time adaptability. To address these challenges, we propose the Dynamic Banker’s Deadlock Avoidance Algorithm (DBDAA). The DBDAA introduces real-time processing for safety checks, significantly improving system efficiency and reducing the risk of deadlocks. Unlike conventional methods, the DBDAA dynamically includes processes in safety checks, considerably decreasing the number of comparisons required to determine safe states. This optimization reduces the time complexity to O(n) in the best-case and O(nd) in the average and worst-case scenarios, compared to the O(n2d) complexity of the original Banker’s algorithm. The integration of real-time processing ensures that all processes can immediately engage in safety checks, improving system responsiveness and making the DBDAA suitable for dynamic and time-sensitive applications. Additionally, the DBDAA introduces a primary unsafe sequence mechanism that enhances the acceptability and efficiency of the algorithm by allowing processes to participate in safety checks repeatedly after a predetermined amount of system-defined time. Experimental comparisons with existing algorithms demonstrate the superiority of the DBDAA in terms of reduced safe state prediction time and increased efficiency, making it a robust solution for deadlock avoidance in real-time systems.
Anatomical and Micro-CT measurement analysis of ocular volume and intraocular volume in adult Bama Miniature pigs, New Zealand rabbits, and Sprague-Dawley rats
Authors: Wu Yajun , Feng Yuliang , Yang Jiasong , Ran Yuwen , Shu Zongtao , Cen Xiaobo , Li Wensheng
Published: September 2024

Aim

Utilizing a combination of micro-computed tomography (micro-CT) and anatomical techniques for the volumetric assessment of the eyeball and its constituents in Bama Miniature Pigs, New Zealand rabbits, and Sprague-Dawley(SD) rats.

Method

Six Bama Miniature pigs, New Zealand rabbits, and SD rats were enrolled in the study. Micro-CT and gross volumetric estimation of ocular volume were employed to acquire data on ocular volume, anterior chamber volume, lens volume, and vitreous cavity volume for each eye.

Results

The eyeball volume of pigs ranges from approximately 5.36 ± 0.27 to 5.55 ± 0.28 ml, the lens volume from approximately 0.33 ± 0.02 to 0.37 ± 0.06 ml, the anterior chamber volume from approximately 0.19 ± 0.05 to 0.28 ± 0.04 ml, and the vitreous volume is approximately 3.20 ± 0.18 ml. For rabbits, the eye volume, lens volume, anterior chamber volume, and vitreous volume range from approximately 3.02 ± 0.24 to 3.04 ± 0.24 ml, 0.41 ± 0.02 to 0.44 ± 0.02 ml, 0.23 ± 0.04 to 0.26 ± 0.05 ml, and 1.54 ± 0.14 ml, respectively. In SD rats, the volumes are 0.14 ± 0.02 to 0.15 ± 0.01 ml for the eyeball, 0.03 ± 0.00 to 0.03 ± 0.00 ml for the lens, 0.01 ± 0.00 to 0.01 ± 0.01 ml for the anterior chamber, and 0.04 ± 0.01 ml for the vitreous volume.

Conclusion

The integration of micro-CT and gross volumetric estimation of ocular volume proves effective in determining the eyeball volume in Bama Miniature Pigs, New Zealand rabbits, and SD rats. Understanding the volume distinctions within the eyeballs and their components among these experimental animals can lay the groundwork for ophthalmology-related drug research.
The impact of the early COVID-19 pandemic on maternal mental health during pregnancy and postpartum
Authors: Bartmann Catharina , Kimmel Theresa , Davidova Petra , Kalok Miriam , Essel Corina , Ben Ahmed Fadia , McNeill Rhiannon V. , Wolfgang Tanja , Reif Andreas , Bahlmann Franz , Wöckel Achim , Trautmann-Villalba Patricia , Kämmerer Ulrike , Kittel-Schneider Sarah
Published: September 2024

Purpose

The aim of this study was to investigate the effects of the COVID-19 pandemic on maternal mental health during pregnancy and the postpartum period.

Methods

The impact of the COVID-19 pandemic situation during and post pregnancy was addressed on three main factors; maternal mental health, mother-child bonding, and maternal self-confidence. To do this, two different patient cohorts were compared; data from one cohort was collected pre-pandemic, and data was collected from the other cohort at the beginning of the pandemic. Questionnaires were used to collect data regarding depressive symptoms (Edinburgh Postnatal Depression Scale [EPDS]), anxiety (State Trait Anxiety Inventory [STAI]), maternal self-confidence (Lips Maternal Self-Confidence Scale [LMSCS]) and mother-child bonding (Postpartum Bonding Questionnaire [PBQ]).

Results

There were no significant differences in depressive symptoms (EPDS with an average median of 4.00–5.00) or anxiety (STAI with an average median of 29.00–33.00) between the cohorts. However, the quality of postpartum maternal bonding was higher at 3–6 months in the pandemic cohort, which was also influenced by education and the mode and number of births. The maternal self-confidence was lower in the pandemic sample, also depending on the mode of birth delivery.

Conclusions

In this study, a differential effect of the COVID-19 pandemic on mother-child bonding and maternal self-confidence was observed. The results thereby identified possible protective factors of the pandemic, which could potentially be implemented to improve maternal mental health and bonding to the child under normal circumstances.