bluuebunny/crossref_metadata_2025 huggingface dataset:
Vectors of culture
Authors:   Saratov State University, Elina Elena G.
Published: December 2022

This is a review of a collected volume of articles prepared by Professor M. Stroganov for his 70th Anniversary. The book intertwines two main academic interests of the author, mixed up in a special, unique to the researcher, methodological paradigm. These are the attention to the literary or folklore text as well as the focus on the diversity of Russian culture in its broadest spectrum: song and singing, music and painting, and the various facets of the theatrical arts. These two components of academic exploration in the work of Stroganov are in constant interaction and mutual influence. The author goes on to explore not only the obvious manifestations of these connections, but also sees in them the d riving force of all Russian artistic thought, the search for the aesthetic ideal, and the answers to the burning questions of Russian life. The key aspect explored in the book’s chapters is the dialectics of high culture and mass culture. The author argues that mass culture is not just a negative episode in the development of a culture which should be resolved to avoid distortions, but a feature of the historical development of society. This occurs, according to the author, due to the fact that mass culture is formed simultaneously with the emergence of the original high literature. The opinions of many prominent literary and artistic figures against the cheap popularity of mass culture, its gravitation towards tastelessness, violation of sacredness, trivialisation and distortion of the sublime, provoke the author of the reviewed book to have a serious and substantiated discussion about the mass culture. For the author, mass culture has its own parameters and boundaries, with its own separate tasks and ways of realisation; it has its own reader-viewer-listener, and is thus the most important object of an academic study. М. Stroganov formulates the specifics of this object and creates a system for its analytical description.
Rosemary and CoQ10 Alleviated the Detrimental Effects of Concomitant Administration of Acetaminophen and Carbamazepine by Accelerating Their Metabolism and Elimination
Authors: Hamido Marwa Magdy , Zaki Nashwah Ismail , Nasr Sawsan Ahmed , El-Sayed Wael Mohamed
Published: December 2022

BACKGROUND: The interaction of carbamazepine (CBZ) and acetaminophen (APAP) could result in hepatic failure and mortality. This study was conducted to analyzed the potential of rosemary ethanol extract (REE) or coenzyme Q10 (CoQ10) to alleviate the interactions between CBZ and APAP.METHODS: Fourty-eight adult male rats were treated differently based on the assigned groups. Oxidative stress parameters, including malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase, and glutathione S-transferase (GST), and the expression levels of CYP3A4, CYP2E1, IL-6, TNF-α, and IL-1B in the liver were estimated. In addition, the histopathology of liver was examined and the plasma clearance rate of CBZ and APAP was estimated.RESULTS: Combination of CBZ and APAP significantly elevated alanine aminotransferase (ALT) activity and hepatic MDA, and reduced the activities of GPx, GST, and GSH level in liver. The gene expression of CYP3A4 and CYP2E1 was upregulated by CBZ and CoQ10, respectively. The expression of IL-6 has decreased in the groups treated with CBZ alone or in combination with APAP. TNF-α expression was significantly downregulated in the groups treated with CBZ, APAP, REE, CoQ10, or combination CBZ and APAP. The liver from CBZ and APAP combination group showed centrolobular degeneration and necrosis. REE and CoQ10 were able to alleviate most of these detrimental effects. The combined administration of CBZ and APAP extended the plasma clearance time of APAP and CBZ from 6 to 24 and from 9 to 24 hours, respectively.CONCLUSION: REE and CoQ10 alleviated the detrimental effects of the combination of CBZ and APAP through enhancing the cellular antioxidant milieu, induction of metabolizing enzymes, reduction of the plasma half-life of APAP and CBZ preventing their accumulation and potential interaction.KEYWORDS: acetaminophen, antioxidants, carbamazepine, CoQ10, CYP3A4, CYP2E1, glutathione, lipid peroxidation, rosemary
Paneth Cell Hyperplasia and Metaplasia in Hirschsprung-associated Enterocolitis in An Aganglionosis Rat Model
Authors: Budianto Iskandar Rahardjo , Firmansyah Agus , Moenadjat Yefta , Jusuf Ahmad Aulia , Soetikno Vivian
Published: December 2022

BACKGROUND: Many hypotheses regarding the pathophysiology of enterocolitis in aganglionic megacolon or Hirschsprung disease (HSCR) has been proposed. Paneth cells are columnar intestinal epithelial cells that have an important role in maintaining of intestinal homeostasis as a bactericide. Since enterocolitis in HSCR may have association with Paneth cells metaplasia and hyperplasia, current study investigated Paneth cells metaplasia and hyperplasia in the sigmoid colon of HSCR rat model and its products, namely a-defensins and IL-1b, in the sigmoid colon tissues.METHODS: Aganglionosis-induced and control Sprague-Dawley rats were euthanized on Day (D)-7, -14, -17, -19, -21, -23, -25, and -28. Sigmoid colon tissue was isolated at each time point, and degree of enterocolitis as well as Paneth cells metaplasia and hyperplasia were analyzed by Hematoxylin-eosin staining, then protein levels of a-defensins and interleukin (IL)-1b were determined by enzyme-linked immunosorbent assay (ELISA).RESULTS: Enterocolitis scores increased with time. The Paneth cells metaplasia and hyperplasia were observed on D14 until D28 (p<0.01 vs. control group) followed by an increased in the levels of IL-1b. The levels of a-defensins protein expression were initially increased (D7-D14; p<0.01 vs. control group) but then undergo reciprocal changes on D19 until D28 (p<0.01 vs. D7 and D14). Positive correlations between the degree of enterocolitis and Paneth cells number were detected in the sigmoid colon (r=0.42).CONCLUSION: Paneth cells underwent metaplasia and hyperplasia in the sigmoid colon of HSCR rats corresponding to an increase in the degree of enterocolitis, but not followed by an increase in the level of a-defensins as well as IL-1b, suggesting that there is an involvement of Paneth cells in the pathophysiology of enterocolitis due to HSCR.KEYWORDS: Hirschsprung, enterocolitis, defensins; metaplasia, Paneth cell, animal model
Caffeic Acid Inhibits Tumour Mass Formation in MG-63 Cells-induced Nude Mice
Authors: Sandra Ferry , Ranggaini Dewi , Hendamin Laifa Annisa , Dewi Nurrani Mustika , Djamil Melanie Sadono
Published: December 2022

BACKGROUND: Formation of tumour mass is one symptom of osteosarcoma development. Caffeic acid has been known to provide effective treatment but has less side effect for some cancer therapy. Studies reported that caffeic acid might promote apoptosis in MG-63 osteosarcoma cells, however, the effect of caffeic acid treatment in preventing tumour mass formation has not been well elucidated, especially in MG-63 cells-induced nude mice in vivo.METHODS: MG-63 cells were pre-treated with 0, 1, or 10 µg/mL caffeic acid, and 6 hours after pre-treatment, MG-63 cells were injected into subcutaneous space of mice to induce osteosarcoma. Another model was also created by subcutaneously injecting MG-63 cells to the back of mice, and after 48 days, the visible tumour mass was injected intra-tumour with 0 or 10 µg/mL caffeic acid every 7 days for 6 times. After 90 days, mice were anaesthetised, and the nodule pictures were taken for observation and measurement. RESULTS: In pre-treated MG-63 cells-induced mice, volumes of the mass decreased in reverse with the dose of caffeic acid given. Ten µg/mL caffeic acid pre-treatment was able to significantly lower the mass volume compared to the untreated (p<0.05). Meanwhile, the intra-tumour treatment of 10 µg/mL caffeic acid, even though not significant, was able to inhibit tumour mass formation.CONCLUSION: Results of caffeic acid pre-treatment and caffeic acid treatment in tumour mass of mice show that caffeic acid is able to inhibit the MG-63 cells formation. This suggests that caffeic acid can be a potential anti-cancer agent.KEYWORDS: caffeic acid, osteosarcoma, MG-63 cells, tumour mass
El capital sociocomunal en la encrucijada del desarrollo
Authors: Bolaños Garita Rolando
Published: December 2022

La presente investigación es producto de nuestra labor académica-investigativa en la Escuela de Ciencias de la Administración en la Universidad Estatal a Distancia de Costa Rica (UNED), cuyo fin principal fue ahondar investigativamente en las condiciones de apoyo gubernativo al movimiento comunal costarricense –con miras a la autosuficiencia– mediante la conformación de un Capital Social Comunal, mismo que se constituirá en patrimonio de la colectividad y en herramienta para el desarrollo. De esta forma, con base en la aplicación de técnicas investigativas como el análisis documental y la entrevista, se arriba a inferencias sobre los sujetos sociales que coadyuvan en el desarrollo integral del país, a pesar de que aún resta fortalecer en ellos una cultura empresarial para el autosostenimiento y la no dependencia de los presupuestos públicos.
Las relaciones entre el Perú y Alemania (1828-2003)
Authors: Novak Talavera Fabián
Published: December 2022

El presente trabajo está dividido en cinco secciones. La primera cubre los primeros contactos entre los que serían los Estados del Perú e Italia, sucedidos antes de 1821, y hace hincapié en la llegada de los primeros pobladores de la península itálica al Perú; en la consolidación de la influencia italiana en esta parte de América; en la llegada de Carlos III de Borbón, de ascendencia italiana, al trono español; y en el impacto de este último suceso en el virreinato del Perú. La segunda cubre el periodo comprendido entre 1821 y 1870, y en él se aborda la relación de la naciente república peruana con los diversos Estados que se encontraban establecidos en la península itálica hasta su unificación con la creación del reino de Italia en 1861. Esta sección hace énfasis en la emancipación y proclamación de la independencia del Perú, en los avatares de los Estados italianos en su intento por liberarse del dominio austriaco y en el establecimiento de relaciones diplomáticas entre el Perú y algunos Estados italianos antes de la unificación. La tercera se refiere al impacto de la Guerra del Pacífico en la relación entre el Perú e Italia. Este momento es abordado considerando, en primer lugar, la situación de la relación entre el Perú e Italia previa al inicio del conflicto; en segundo lugar, la concreta participación italiana en dicho incidente, tanto en el plano político-diplomático como en el de su comunidad en el Perú; y, en tercer lugar, la forma en que la guerra con Chile influyó concretamente en la relación diplomática entre ambos países. La cuarta está dedicada a la relación bilateral entre el Perú e Italia en el periodo de las dos guerras mundiales. En este capítulo, se estudia por separado los períodos correspondientes a cada uno de esos conflictos bélicos y, también, el periodo que se ubica entre ellos, siempre teniendo en cuenta la actividad diplomática y las tendencias comerciales entre ambos países. Finalmente, la última sección muestra el giro que toma la relación bilateral hacia la cooperación, ya sea ésta técnica, económica, cultural o judicial.
Integrated Nutrient Management in Different Cereal based Cropping Sequences: A Statistical Perspective
Authors: Kumar Anil , Harun Mohd , Dash Sukanta , Sarkar Susheel Kumar , Yadav Sunil Kumar , Chauhary Vipin Kumar , Kumar Devendra
Published: December 2022

Background: In this study, the impact of integrated nutrient management practice in cereal based cropping sequence has been examined. A detail study about the impact of INM in the above cropping system for last 8 years has been carried out.
Method: On-station research experiments were conducted at Karjat centre of district Raigad of Maharashtra, under the ICAR-Indian Institute of Farming Systems Research, Modipuram, Meerut of ICAR-All India Co-ordinated Research Project during the years 2010-11 to 2017-18 on integrated nutrient supply (INM) system in rice – rice (Oryza sativa L.) cropping system at Karjat. Result: 100% recommended NPK dose through fertilizers was identified as the best INM practice at Karjat during kharif season. A detail study about the impact of INM in the above cropping system for last 8 years has been carried out and presented in tabular as well as graphical view both.
Isolation and Identification of Bacterial Endophytes from Grain Amaranth (Amaranthus caudatus) for Plant Growth Promotion
Authors: Bhagyashree K.B. , Shivaprakash M.K. , Reddy M. Raveendra
Published: December 2022

Background: Bacterial endophytes lives in internal tissues of root, stem and leaves of grain amaranth plants. Isolation and screening of efficient bacterial endophytes for plant growth promotion, biocontrol activities and drought tolerance can develop as suitable bioinoculants for alleviate drought and stress tolerance and plant growth promotion. Methods: Bacterial endophytes were isolated from grain amaranth (Amaranthus spp) and all isolates were screened for nitrogen fixation, phosphorous solubilisation, growth hormone production and 1-aminocyclopropane-1-carboxylate (ACC) deaminase production. Molecular identification of bacterial isolates was done by 16S rRNA sequencing to identify the organisms. Result: Seventeen isolates showed high growth in N-free media and nine isolates could efficiently solubilize phosphates. Two isolates significantly produced higher concentrations of gibberellins, maximum number of bacterial isolates produced Indole-3-acetic acid (IAA) and eight isolates were able to produce cytokinins. Fifteen isolates have shown positive for ACC activity [1-Aminocyclopropane-1-carboxylate (ACC) deaminase production] in grain amaranth and five bacterial isolates (RAR-5, RAS-3, RAL-7, WAR-1 and WAS-11) have significant plant growth promoting activities compared to others. Further, significant bacterial isolates were identified as Alcaligenes faecalis subsp. phenolicus, Pseudomonas moorei, Bacillus siamensis, Bacillus cereus and Acromobacter deleyi by 16S rRNA gene sequencing.
Metabolic Profiling of Plant Growth Promoting Microorganisms (PGPMs) from Chickpea Rhizosphere and Their Antagonistic Activity against Dry Root Rot Pathogen Rhizoctonia bataticola
Authors: Patil Meghana S. , Sunkad Gururaj , Yenjeerappa S.T. , Kulkarni Sunil A. , Rao Satyanarayana , Naik Nagaraj M.
Published: December 2022

Background: Dry root rot (DRR) caused by Rhizoctonia bataticola is the major threat to chickpea production globally. Recently, upsurge in disease incidence is observed due to unexpected increase in temperature and soil moisture stress resultant of changing climatic scenarios. To combat this necrotrophic phytopathogenic fungus, the present study was conducted with the aim of managing the disease by using potential rhizospheric PGPMs. Methods: Twenty-six isolates of soil-borne fungal PGPMs were isolated from rhizosphere of chickpea in North Eastern Karnataka zone and screened for bio-active compounds production against Rhizoctonia bataticola by inverted plate technique. Using ITS genes BLAST analysis, the putative rhizospheric fungal PGPM was identified at the molecular level. Finally, chemical characterization of the bio-active compounds and metabolic profiling was carried out using Gas Chromatography Mass Spectrometry (GC-MS) technique. Result: All the isolates showed significant differences in radial growth of mycelium at five days after incubation. SFPGPM-13 isolate produced maximum concentration of bio-active compounds with per cent mycelial inhibition of 62.83 (52.43). Molecular identification and BLAST analysis showed the isolate SFPGPM-13 was identified as Trichoderma harzianum. GC-MS analysis resulted that 62 compounds were present in the extract of SFPGPM-13 at different retention time and mass to charge (m/z) ratio.
PENGOPTIMALAN PENGGUNAAN TEKNOLOGI MELALUI QUIZIZZ UNTUK MENINGKATKAN HASIL BELAJAR PESERTA DIDIK DI MAN 1 KOTA PROBOLINGGO
Authors: Agustiana Irma Agustiana
Published: December 2022

The rapid development of technology must of course be followed by proper utilization. However, the optimization of technology in learning is not implemented and is actually used for things that are less useful. This actually causes technology to be considered a bad influence on learning. One of the efforts to optimize technology and improve student learning outcomes is to use learning technology. Quizizz is an effort that can be used to improve learning outcomes, especially in the subject of Islamic Cultural History (SKI). This research uses Classroom Action Research (CAR). This research was conducted at MAN 1 Probolinggo City with the research subject being class X-A, totaling 20 students. The results of this study indicate that quizizz can improve student learning outcomes. The first cycle of the study showed an average of 83.4 learning outcomes and increased to 93.8 in the second cycle. So it can be said that quizzz is one of the efforts that can be used to improve student learning outcomes
 
Abstrak
Perkembangan teknologi yang pesat tentunya harus diikuti dengan pemanfaatan yang tepat. Meskipun demikian, optimalisasi teknologi dalam pembelajaran kurang dilaksanakan dan justru digunakan untuk hal-hal yang kurang bermanfaat. Hal itu justru menyebabkan teknologi justru dianggap berpengaruh buruk bagi pembelajaran. Salah satu upaya untuk dapat mengoptimalkan teknologi dan mampu meningkatkan hasil belajar peserta didik adalah dengan menggunakan teknologi pembelajaran yang menarik. Quizizz merupakan salah satu upaya yang dapat digunakan untuk meningkatkan hasil belajar khususnya pada mata pelajaran Sejarah Kebudayaan Islam (SKI). Penelitian ini menggunakan metode Penelitian Tindakan Kelas (PTK). Penelitian ini dilakukan di MAN 1 Kota Probolinggo dengan subjek penelitian adalah kelas X-A yang berjumlah 20 peserta didik. Hasil dari penelitian ini menunjukkan bahwa quizizz dapat meningkatkan hasil belajar peserta didik. Siklus pertama penelitian menunjukkan rata-rata hasil belajar 83,4 dan meningkat menjadi 93,8 pada siklus kedua. Sehingga dapat dikatakan bahwa quizizz merupakan salah satu upaya yang dapat digunakan untuk meningkatkan hasil belajar peserta didik.
Metaverse in Tourism and Hospitality: Empirical Evidence on Generation Z from Italy
Authors: Rancati Elisa , D’Agata Alessandro
Published: December 2022

The paper has been conducted to analyze the change taking place in tourism marketing due to the metaverse innovation through tastes and needs of today's new generations of tourists, especially generation Z, that will be the future customers of the next decades. The goal of this study has been to analyze the opportunities concerning the metaverse and its immersive technology, through a survey conducted on a sample of generation Z people and understand which are the practical implications that can guide tourism companies and territorial governments' decisions during the nearest future, to satisfy new market demand and optimize their communication in the metaverse.
Desafios e limitações na implantação do sistema de custos na Prefeitura Municipal de Fortaleza
Authors: Silva Angeliana Ferreira da , Steindorfer Igor Barroso , Bringel Juliana Holanda Farias de Araripe , Nobre José Geovanildo , Vasconcelos Alessandra Carvalho de
Published: December 2022

A adoção de um sistema de custos por parte da administração pública faz-se impositiva pela legislação brasileira. Assim, esta pesquisa investigou os desafios e limitações enfrentados durante a implantação do Sistema de Informação de Custos (SIC) na Prefeitura Municipal de Fortaleza (PMF). Foi aplicado um questionário junto aos gestores e técnicos que participaram da implantação do SIC na PMF. Os resultados indicam que a integração e a customização dos sistemas e os aspectos relativos às estruturas organizacionais são os principais desafios da PMF, enquanto as principais limitações à implantação do SIC relacionam-se ao escopo e à equipe envolvida. A pesquisa amplia as discussões sobre gestão de custos, ao fornecer evidências que auxiliem o processo decisório no setor público.
External iliac artery injury with posterior pelvic ring injury in Korea: a report of two cases
Authors: Ahn Joosuk , Kim Ji Wan
Published: December 2022

Pelvic ring injuries associated with external iliac artery injuries are rare and may be life-threatening condition. The most important factors in the managements are the immediate bleeding control and restoration of distal blood flow. We report two cases of pelvic ring injuries with external artery injuries. One case was occlusion of external iliac artery with concomitant rupture of internal iliac artery. The other case was ruptured external iliac artery. Every surgeon must understand the possibility of hidden lesions—for example, arterial rupture and thrombus—and should consider the need for embolization or thrombectomy when treating this type of injury.
Acute Osteoporotic Vertebral Fracture. Part 2. Differential Diagnostics According to the Data of Imaging Methods. Conservative and Surgical Treatment
Authors: Lyalina V. V. , Borshenko I. A. , Borisovskaya S. V. , Skripnichenko E. A. , Binyakovskiy R. V. , Solomin V. D. , Trishina V. V. , Nikitin I. G.
Published: December 2022

Osteoporosis is a widespread metabolic disease of the skeleton among the elderly. Osteoporotic fractures are significant manifestation of the disease, which can substantially affect the quality of life. The purpose of this article is to review approaches to the management of patients with acute osteoporotic fracture. This article consists of two parts. The first part reviews general information about osteoporosis, clinical course of osteoporotic fracture, differential diagnosis of pain syndrome, methods of visualization of fractures, differential diagnosis of osteoporosis. In the second part, we discuss differential diagnosis of osteoporotic fracture according to the data of imaging methods, non-pharmacologic, pharmacologic and surgical methods of treatment.
Pengaruh Metode Pembelajaran Tutor Sebaya Terhadap Minat Belajar Peserta Didik Kelas Viii Mata Pelajaran Pendidikan Agama Islam Di Mts Yayasan Anak Emas Bali Tahun Ajaran 2018/2019
Authors: Subekti Rohmat , Mulyadi  , Dewantoro Hajar
Published: December 2022

Metode tutor sebaya merupakan strategi pembelajaran yang melibatkan langsung siswa dalam proses belajar. Dengan demikian penerapan metode tutor sebaya sangat cocok digunakan untuk meningkatkan minat belajar siswa disekolah. Dalam proses pembelajaran, minat siswa memiliki peranan yang sangat penting untuk mencapai hasil pembelajaran yang optimal. Oleh karena itu penelitian ini bertujuan untuk mengetahui ada atau tidak pengaruh metode pembelajaran tutor sebaya terhadap minat belajar siswa kelas VIII pada mata pelajaran pendidikan Agama Islam di Mts Generasi Emas Bali. Penelitian ini menggunakan pendekatan kuantitatif. Teknik pengumpulan data yang digunakan pada penelitian ini adalah observasi, angket, wawancara dan dokumentasi. Subjek penelitian ini adalah siswa kelas VIII di Mts Generasi Emas Bali  yang berjumlah 32  siswa. Teknik analisis pada penelitian ini menggunakan analisis regresi sederhana. Uji asumsinya menggunakan uji normalitas, uji homogenitas, dan linearitas yang diolah dengan bantuan komputer program SPSS versi 22 for windows. Hasil penelitian ini menunjukkan pada jumlah responden 30 siswa, ada pengaruh yang signifikan antara penerapan tutor sebaya  terhadap minat belajar siswa dalam mata pelajaran Pendidikan Agama Islam di Mts Generasi Emas Bali. Hal tersebut ditunjukkan dengan hasil perhitungan tingkat probabilitas signifikan sebesar 0,003 , dengan demikian p < 0,005, berarti Ha diterima dan Ho ditolak. Hal ini dapat diinterpretasikan bahwa terdapat pengaruh yang signifikan antara metode pembelajaran tutor sebaya terhadap minat belajar peserta didik kelas 8  mata pelajaran pendidikan agama islam di Mts Generasi Emas Bali. Keyword : pendidikan, tutor sebaya, minat belajar,
A High-Performance Stability-Indicating Liquid Chromatographic Novel Method for Determining Recombinant Human Erythropoietin in Bulk and Dosage Form
Authors: Kothawade Sachin Namdeo , Pande Vishal Vijay , Albhar Shubhangi Nivrutti , Bole Sandesh Sacchidanand , Raut Kunal Ganesh , Wagh Vaibhav Sudhakar
Published: December 2022

An HPLC method for indicating stability was developed, created, and confirmed for the quantification measurement of recombinant human erythropoietin in large quantities as well as dosage forms. An isocratic separation was accomplished using a Thermo Biobasic C18 (250 mm 4.6 mm i.d., 300Ao, 5 m) column with a flow rate of 1.0 mL min-1 as well as a UV detector to monitor the eluate at 278 nm. Acetonitrile, 0.05 mM potassium dihydrogen phosphate (80:20 v/v), and orthophosphoric acid adjusted to 4.0 made up the mobile phase. The drug was exposed to oxidative stress, hydrolysis, and photodegradation to simulate stress conditionsRecombinant Human Erythropoietin, the parent compound, was eluted at roughly 6.675 minutes, as well as all byproducts have been entirely disconnected inside an overall analytical run time of about 15 minutes. To identify quantification limits of 0.05 and 0.2 g mL-1, respectively, the method was linear over a concentration range of 1-6 g mL-1 (r = 0.9989). Recombinant Human Erythropoietin can be measured accurately, selectively, sensitively, and precisely using this method both in dosage form and in bulk. Stress-induced degradation products did not interact with the identification of Recombinant Human Erythropoietin, indicating that the assay is stable.
Elucidation of the Strong Effect of the Annealing and the Magnetic Field on the Magnetic Properties of Ni2-based Heusler Microwires
Authors: Salaheldeen Mohamed , Wederni Asma , Ipatov Mihail , Zhukova Valentina , González Julian Maria , Zhukov Arcady
Published: December 2022

We studied the effect of annealing and the applied magnetic field from 50 Oe to 20 kOe on the magneto-structural behavior of Ni2FeSi-based Heusler microwires fabricated by using Taylor-Ulitovsky technique. Using the XRD analysis, a strong effect of annealing, manifested as the development of the crystallization process, was observed. The average grain size and crystalline phase content of annealed sample increase from 21.3 nm and 34 % to 32.8 nm and 79%, respectively, as-compared to the as-prepared one. In addition, upon annealing phase transforms into a monoclinic martensitic structure with modulation 10M were observed, which cannot be found in the as-prepared sample. Concerning the magnetic properties, both samples show ferromagnetic behavior below and above the room temperature, where the Curie temperature of Ni2FeSi is higher than room temperature. The induced secondary phases have a noticeable effect on the magnetic behavior of the annealed sample, where a high normalized saturation magnetization (NMs) and low normalized reduced remenance (Mr = M/M5K), compared to the as- prepared have been detected. Additionally, the coercivity of annealed sample shows one flipping point at 155 K where it behavior with temperature is changed. Meanwhile, the as-prepared sample show two flipped point at 205 K and 55 K. A mismatch between field cooling (FC) and field heating (FH) magnetization curves with temperature has been detected for annealed sample at low applied magnetic field. In addition the FC and FH curves shows different slopes with variation the temperature and the magnetic field. By increasing the external magnetic field higher than 200 Oe and up to 20 kOe a gradual changing in the magnetic behavior has been detected, where the mismatch and different slopes disappeared at applying magnetic field about 20 kOe. The difference in magnetic and structure behavior of Ni2FeSi microwires sample is discussed considering the effect of induced internal stresses by the presence of a glass coating and the recrystallization and stresses relaxation upon annealing.
Voronoi Tessellations and the Shannon Entropy of the Pentagonal Tilings
Authors: Bormashenko Edward , Legchenkova Irina , Frenkel Mark , Shvalb Nir , Shoval Shraga
Published: December 2022

We used the complete set of convex pentagons enabling filing the plane without any overlaps or gaps (including the Marjorie Rice tiles) as generators of Voronoi tessellations. Shannon entropy of the tessellations was calculated. Some of the basic mosaics are flexible and give rise to a diversity of Voronoi tessellations. The Shannon entropy of these tessellations varied in a broad range. Voronoi tessellation, emerging from the basic pentagonal tiling built from hexagons only, was revealed (the Shannon entropy of this tiling is zero). Decagons and hendecagon did not appear in the studied Voronoi diagrams. The most abundant Voronoi tessellations are built from three different kinds of polygons. The most widespread is the combination of pentagons, hexagons and heptagons. The most abundant polygons are pentagons and hexagons. No Voronoi tiling built only of pentagons was registered. Flexible basic pentagonal mosaics give rise to a diversity of Voronoi tessellations, which are characterized by the same symmetry group; however, the coordination number of the vertices is variable. These Voronoi tessellations may be useful for the interpretation of the iso-symmetrical phase transitions.
Hybrid Silica-Coated PLGA Nanoparticles for Enhanced Enzyme-Based Therapeutics
Authors: Gustafson Kyle T. , Mokhtari Negin , Manalo Elise C. , Montoya Mira Jose , Gower Austin , Yeh Ya-San , Vaidyanathan Mukanth , Esener Sadik C. , Fischer Jared
Published: December 2022

Some cancer cells rely heavily on non-essential biomolecules for survival, growth, and proliferation. Enzyme based therapeutics can eliminate these biomolecules, thus specifically targeting neoplastic cells; however, enzyme therapeutics are susceptible to immune clearance, exhibit short half-lives, and require frequent administration. Encapsulation of therapeutic cargo within biocompatible and biodegradable poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) is a strategy for controlled release. Unfortunately, PLGA NPs exhibit burst release of cargo shortly after delivery or upon introduction to aqueous environments where they decompose via hydrolysis. Here we show the generation of hybrid silica-coated PLGA (SiLGA) NPs as viable drug delivery vehicles exhibiting sub-200 nm diameters, a metastable Zeta potential, and high loading efficiency and content. Compared to uncoated PLGA NPs, SiLGA NPs offer greater retention of enzymatic activity and slow the burst release of cargo. Thus, SiLGA encapsulation of therapeutic enzymes, such as asparaginase, could reduce frequency of administration, increase half-life, and improve efficacy for patients with a range of diseases.
A Study on the Optimization of Talent Training Program for English Majors in Yangtze University-Based on Surveys of Graduate Employability
Authors: Juan Wang
Published: December 2022

This paper, combined with the orientation of the School of Foreign Languages of Yangtze University that aims to cultivate "broad caliber, thick foundation, strong ability, high quality" talents, professional touch and employment channels for students, constructs a model framework for the employability of English major students. Meanwhile, based on the surveys of the employability of English majors in our school, the paper puts forward some proposals for optimizing the talent training program: Improving students’ competitiveness in the workplace and cultivating applied foreign language talents suitable for the needs of society by perfecting the discipline system, innovating the practice mode, expanding training channels and improving employment guidance.
A COVID-19 Vaccination Program to Promote Uptake and Equity for People Experiencing Homelessness in Los Angeles County
Authors: Rosen Allison D. , Senturia Alexander , Howerton Isabelle , Kantrim Emily Uyeda , Evans Vanessa , Malluche Tiffany , Miller Jonni , Gonzalez Miriam , Robie Brooke , Shover Chelsea L. , Chang Alicia H. , Behforouz Heidi , Nguyen Anh , Thomas Emily H.
Published: December 2022

People experiencing homelessness (PEH) have been disproportionately affected by COVID-19, yet their vaccination coverage is lower than is that of the general population. We implemented a COVID-19 vaccination program that used evidence-based and culturally tailored approaches to promote vaccine uptake and equity for PEH in Los Angeles County, California. From February 2021 through February 2022, 33 977 doses of vaccine were administered at 2658 clinics, and 9275 PEH were fully vaccinated. This program may serve as a model for future service delivery in vulnerable populations. (Am J Public Health. 2023;113(2):170–174. https://doi.org/10.2105/AJPH.2022.307147 )
Outcomes of cesarean myomectomy among pregnant women with uterine leiomyomas: A single tertiary center experience
Authors: Acar Ali , Atci Aslı Altınordu , Doğru Şükran , Akkuş Fatih , Gümüş Meryem
Published: December 2022

Purpose: This study aimed to investigate the surgical outcomes and safety of cesarean section myomectomies.
Methods: This retrospective study was performed between January 2015 and August 2022, at a single university hospital. Pregnant women diagnosed with myoma uteri who underwent C/S (cesarean section) myomectomy and pregnant women without myoma as the control group and only underwent C/S were included in the study. Patients' age, gravida, parity, abortion, body mass index (BMI), delivery week, previous delivery type, myoma size, type, number, localization, preoperative and postoperative hemoglobin (Hb) values and postoperative Hb changes, operation time, hospital stay, blood transfusion need and amount, and postoperative complications were recorded from the hospital archive system. The obtained data were compared between the two groups.
Results: A total of 283 patients underwent C/S myomectomy and 324 patients who did not have myoma underwent only C/S. Duration of operation, length of hospital stay, postoperative blood transfusion need and amount of blood transfusion, preoperative Hb, and change of Hb values were statistically significantly higher in the C/S myomectomy group (p<0.01, p<0.01, p=0.005, p= 0.006, p<0.01, p<0.01, respectively). A statistically significant weak positive correlation was observed between fibroid size and hospital stay (ρ=0.133). There was a statistically significant weak positive correlation between the size of myoma and the amount of blood transfused (ρ=0.120).
Conclusion: Myomectomy during cesarean section has a low complication rate and saves patients from the necessity of a second operation.
On the consensus in climate policy scenarios
Authors: Dekker Mark , Hof Andries , Berg Maarten van den , Daioglou Vassilis , Heerden Rik van , Wijst Kaj-Ivar van der , Vuuren Detlef van
Published: December 2022

Analysis of large scenario databases has become a critical tool for identifying climate mitigation strategies, as shown in the latest IPCC report. However, key elements of these strategies differ significantly among scenarios. Possible reasons include differences in climate target, models used, and assumptions on behavioral, technological and socio-economic developments. For policymaking, it is important to know which of these factors are the main cause of the spread, but quantification of this is still missing. Here, we aim to identify consensus in climate policy scenarios by analyzing how much of the variance in scenario outcomes can be explained by these factors, using Sobol decomposition. Some results, e.g. concerning future use of fossil and renewable resources, are mainly determined by climate target, while others, such as the composition of different renewables in the electricity mix and key outcomes of end-use sectors are more model dependent. Scenario aspects beyond model and climate outcome determine only a limited part of the variation, e.g., in nuclear power and hydrogen use, which suggests the need of more cross-model scenario variation. The outcomes put mitigation strategies in a new perspective by identifying which findings on the energy transition are robust and reveal key areas for future scenario development, model improvement and research.
Improving Patient-Centered Communication in Breast Cancer: A Study Protocol for a Multilevel Intervention of a Shared Treatment Deliberation System (SharES) within the NCI Community Oncology Research Program (NCORP) (Alliance A231901CD)
Authors: Hawley Sarah , Kidwell Kelley , Zahrieh David , Barber Anne , Wills Rachel , Rankin Aaron , Chow Selina , Hofer Timothy , Jagsi Reshma , Neuman Heather
Published: December 2022

Background: Advances in precision medicine have given oncologists new evaluative tools to better individualize treatments for patients with curable breast cancer. These innovations have revealed a need to improve patient understanding of novel, often complex information related to breast cancer treatment decisions. Ensuring patients have the emotional support to face consequential treatment decisions, as well as the opportunity to engage and discuss with their clinicians, is key to improving patient-centered communication and patient understanding.
Methods/design: This study will implement a multilevel intervention with patient and clinician components as a NCORP Cancer Care Delivery Research (CCDR) trial within the Alliance for Clinical Trials in Oncology Research Base (Alliance). The two interventions in this study, the Shared Decision Engagement System (SharES), include: 1) two versions of an evidence-based patient-facing breast cancer treatment decision tool (iCanDecide +/- an emotional support module), and 2) a clinician-facing dashboard (Clinician Dashboard) that is reviewed by surgeons/clinicians and summarizes ongoing patient needs. The design is a near minimax, hybrid stepped wedge trial of SharES where both interventions are being evaluated in a crossed design over six 12-week time periods. The primary outcome (knowledge) and key secondary outcomes (i.e., self-efficacy and cancer worry) are assessed via patient report at 5-weeks after surgery. Secondary outcomes are also assessed at 5-weeks after surgery, as well as in a second survey 9-months after registration. We anticipate recruiting a total of 700 breast cancer patients (600 evaluable after attrition) from 25 surgical practices affiliated with Alliance.
Discussion: Upon study completion we will have better understanding of the impact of a multilevel intervention on patient centered communication in breast cancer with a specific focus on whether the intervention components improve knowledge, self-efficacy and reduce cancer worry.
Trial Registration: NCT04549571. Registered September 16, 2020.
https://clinicaltrials.gov/ct2/show/NCT04549571
Virtual primary care for people living with dementia in Canada: Cross-sectional surveys of patients, care partners, and family physicians
Authors: Khanassov Vladimir , Cetin-Sahin Deniz , Feldman Sid , Sivananthan Saskia , Grill Allan , Vedel Isabelle
Published: December 2022

Background: Despite the importance of virtual primary care, the evidence informing optimal and sustainable provision of virtual care (VC) for people living with dementia (PLWD) and their care partners is scarce. We aimed to describe VC provided by family physicians (FPs) for PLWD in Canada.
Methods: Concurrent mixed-methods design. We analyzed questions related to VC in three nationwide cross-sectional surveys conducted with PLWD, care partners, and FPs in the first year of the COVID-19 pandemic. Virtual care was defined as two-way synchronous communication by telephone and/or a web camera. The prevalence of VC use among FPs, PLWD, and care partners was described, and logistic regression models were used to determine factors (sociodemographic, urbanicity, frequency of and availability of support for connecting to FPs, and FPs’ practice characteristics) associated with VC use. Inductive thematic analysis was performed on responses to open-ended questions to explore FPs’ perceptions of barriers and facilitators to using VC.
Results: 131 PLWD, 341 care partners, and 125 FPs participated. 61.2% of PLWD, 59.5% of care partners, and 77.4% of FPs had used VC. The models for PLWD (included age and ethnicity) and care partners (included gender, urbanicity, and receiving support from a family member/friend to connect with FP) were inconclusive. Among FPs, having more than 20 years of practice was significantly associated with a decreased likelihood of providing VC (OR=0.23, 95%CI: 0.08-0.62, p<0.01). Care preferences (decision stage), office/family support (preparation stage), technology and family presence (execution stage), and remuneration for FPs (compensation stage) were the most commonly recurring themes affecting VC use.
Conclusions: Virtual primary dementia care uptake was substantial and mainly performed via telephone. From the perspective of FPs, optimal VC provision requires patient-care partner-physician shared decision-making, interoperability in healthcare, support for performing VC, and appropriate compensation. Virtual care facilitates access to primary care and minimizes potential disruptions to in-person care for PLWD; however, its outcomes need further investigation.
Rapidly progressive dementia with an atypical presentation of rigid-akinetic syndrome caused by Cryptococcus Gattii: A case report
Authors: García-Cifuentes Elkin , Farelo-Gómez Laura Agustina , Torres Isabel , García-Alfonso Carolina , Mejía-Grueso Andrea , Acosta María-Fernanda , Cleves Catalina Cerquera
Published: December 2022

Background

Meningoencephalitis by Cryptococcus gattii (C. gattii) can be responsible for unspecific neurological clinical features, and its lesions in the brain can be diffuse with a preference for basal ganglia.

Case presentation

Here we describe the case of a 72- year-old woman who developed dementia and akinetic rigid syndrome with bilateral hand myoclonus in six-month period. Brain magnetic resonance imaging revealed striking leptomeningeal compromise and lesions in the midbrain. Film array and culture for C. gattii in cerebrospinal fluid were positive and she was diagnosed with meningoencephalitis by C. gattii. Antifungal management with amphotericin B plus flucytosine was started, and induction therapy was proposed for 4 to 6 weeks.

Conclusions

Our case showed that meningoencephalitis by C. gattii associated with rapidly progressive dementia, gait disturbance and a pseudo-parinaud syndrome could be an atypical clinical presentation of meningoencephalitis by cryptococcus.
Gestational trophoblastic neoplasia with primary lung cancer and mesenchymal tumor of sigmoid colon:a case report and literature review
Authors: Li HongYe , Sun Meng , Jiang Jing , Shi Bin , Wang BaoHua , Wang Lei , Wu WenXin , Wang WenYan
Published: December 2022

Background

Gestational trophoblastic neoplasia(GTN) is rare, and it is even rarer for GTN to merge with primary malignant tumors in other organs. The clinical data of one case of GTN combined with primary lung cancer and mesenchymal tumor of the sigmoid colon were retrospectively analyzed, and summarized by reviewing relevant literature. To explore the incidence, diagnosis and treatment of GTN combined with primary malignant tumors in other organs.

Case presentation

The patient was hospitalized due to diagnosis of GTN with primary lung cancer. Firstly, two cycles of chemotherapy including 5-fluorouracil (5-FU) and actinomycin-D(Act-D) was given. Laparoscopic total hysterectomy and right salpingo-oophorectomy was performed during the third chemotherapy. During the operation, a 3*2cm nodule was removed which was protruded from the serous surface of the sigmoid colon, and the nodule was confirmed mesenchymal tumor pathologically, in accord with gastrointestinal stromal tumor. During the treatment of GTN, Icotinib tablets were taken orally to control the progression of lung cancer. After 2 cycles of consolidation chemotherapy of GTN, she received thoracoscopic lower lobe of right lung lobectomy and the mediastinum lymph nodes removal. She undertook gastroscopy and colonoscopy and the tubular adenoma of the descending colon was removed. At present, the regular follow-up is taken and she remains free of tumors.

Conclusion

GTN combined with primary malignant tumors in other organs are extremely rare in clinical practice and will increase the difficulty of GTN staging and treatment, and bring more challenges to clinicians. It should be emphasized to make comprehensive judgment, and choose a reasonable treatment plan according to the priorities of different tumors.
Multi-responsive 3D Structured PVDF Cube Switch for Security System Using Piezoelectric Anisotropy
Authors: Song Yujun , Jo Hyeongjin , Song Ji-Hyeon
Published: December 2022

Advancements in flexible electronics using piezoelectric materials have paved the way for their numerous applications. In this study, we suggest a 3D structured polyvinylidene fluoride (PVDF) film cube switch to maximize piezoelectric anisotropy and flexibility. Unlike piezoelectric material-based flexible electronics, PVDF cube switches have a simple design and easy fabrication process. Each side of the cube switch demonstrates independent voltage signals with pressing displacements and corresponding directions. With cutting angle variation and planar figure designs, derived cube switches respond with various combination of voltage waveforms. PVDF switches can endure more than 1000 cycles of 70% vertical strain in terms of both electrically and mechanically. As an application, we establish security system with multi-responsibility of a cube switch. This security system can protect users from potential threats owing to its multi-responsibility and user-dependent operability.
A Numerical Example of Russell's Paradox and Its Novel Geometric Properties
Authors: Pan Xiandi
Published: December 2022

I found that its length is neither changed nor unchanged if an endpoint of a line segment is cut off and hypothesized that a line is not composed of points in primary school. Similar findings and hypotheses about plane and space were obtained in middle and high school. An example of Russell's paradox with positive integers - ∅Pan -which I wrote out in the first year of university solved these problems unexpectedly. ∅Pan is a set group that all its sets are mutually included. By marking each set in ∅Pan with line, plane and space, I got ∅line, ∅plane, and ∅space, respectively. These geometric set groups have remarkable properties that lines are mutually included and mutually iterated in ∅line, and the same as planes in ∅plane and spaces in ∅space. Visualization models for ∅line through cross-composing timelines, for ∅plane through cross-monitoring screens, and for ∅space through cross-sharing cyberspaces were finally established when I was pursuing my doctoral degree. These results demonstrate that sets can mutually include and geometries can mutually iterate. I anticipate the present paper to be a starting point for a novel kind of set group and algebraic geometry.