bluuebunny/crossref_metadata_2025 huggingface dataset:
Anonymization of whole slide images in histopathology for research and education
Authors: Bisson Tom , Franz Michael , Dogan O Isil , Romberg Daniel , Jansen Christoph , Hufnagl Peter , Zerbe Norman
Published: May 2023

Objective

The exchange of health-related data is subject to regional laws and regulations, such as the General Data Protection Regulation (GDPR) in the EU or the Health Insurance Portability and Accountability Act (HIPAA) in the United States, resulting in non-trivial challenges for researchers and educators when working with these data. In pathology, the digitization of diagnostic tissue samples inevitably generates identifying data that can consist of sensitive but also acquisition-related information stored in vendor-specific file formats. Distribution and off-clinical use of these Whole Slide Images (WSIs) are usually done in these formats, as an industry-wide standardization such as DICOM is yet only tentatively adopted and slide scanner vendors currently do not provide anonymization functionality.

Methods

We developed a guideline for the proper handling of histopathological image data particularly for research and education with regard to the GDPR. In this context, we evaluated existing anonymization methods and examined proprietary format specifications to identify all sensitive information for the most common WSI formats. This work results in a software library that enables GDPR-compliant anonymization of WSIs while preserving the native formats.

Results

Based on the analysis of proprietary formats, all occurrences of sensitive information were identified for file formats frequently used in clinical routine, and finally, an open-source programming library with an executable CLI tool and wrappers for different programming languages was developed.

Conclusions

Our analysis showed that there is no straightforward software solution to anonymize WSIs in a GDPR-compliant way while maintaining the data format. We closed this gap with our extensible open-source library that works instantaneously and offline.
The predominance of investment in girls’ after-school education in China and the logic of family preferences
Authors: Wei Qingong , Zhang Jianan
Published: May 2023

The gender gap within families regarding access to educational resources is an important social determinant of gender inequality. Contradicting the conventional “preferring sons to daughters” model of household resource allocation, many studies find that Chinese families nowadays prefer to invest in girls’ after-school education. This study focuses on this empirical fact that has not been examined in depth previously, and attempts to explore its key influence mechanisms. Starting from the theoretical context of intergenerational resource allocation, the article suggests two explanatory hypotheses – “change in family gender preferences” and “divergence between mothers’ and fathers’ gender preferences” – in the analysis of the succession of intergenerational preference patterns. An analysis of the China Education Panel Survey (2013–2014) data on families with male siblings and parents with different education levels is conducted. The statistical results show robustly that the presence of brothers in the family does not negatively impact girls’ access to after-school education, that in urban families girls have a pronounced advantage over boys, and that, overall, there has been a tentative shift from “son preference” to “daughter preference” in Chinese families. In addition, under reciprocal controls, the father's increased education has no significant effect on children but a significant positive effect of the mother's increased education is observed on girls’ access to after-school education, and the latter effect is even more pronounced among younger parents, exhibiting a clear pattern of “dual preferences”. These findings, at the empirical level, reveal that the increased family utility of girls compared to boys and the enhanced status of mothers in the process of social change have driven a shift in the logic of family gender preferences.
Association of ANRIL Gene Single-Nucleotide Polymorphisms With Allergic Rhinitis in Kurdish Population From Kermanshah, Iran
Authors: Falahi Sara , Feizolahi Parisa , Monshizadeh Ali , Mahmoudi Zahra , Mahdavi Jila , Salari Farhad , Karaji Ali Gorgin , Rezaiemanesh Alireza
Published: May 2023

Background

Allergic rhinitis (AR) is the most common inflammatory disorder of the upper airway caused by aberrant immune responses to allergens in genetically predisposed individuals. Recently, the long noncoding RNA (lncRNA) antisense noncoding RNA in the INK4 locus (ANRIL) has been identified as a novel genetic factor associated with increased AR risk.

Objectives

This study aimed to evaluate the potential correlation of ANRIL gene single nucleotide polymorphisms (SNPs) with AR risk in the Kurdish population of Kermanshah, Iran.

Methods

In this case–control study, 130 AR patients and 130 healthy controls were recruited to genotype for two SNPs of the ANRIL gene (rs1333048 and rs10757278) using the Tetra-primer amplification refractory mutation system polymerase chain reaction (T-ARMS-PCR) method.

Results

Our results showed no significant difference for the alleles and genotypes frequency distribution of lncRNA ANRIL SNPs (rs1333048 and rs10757278) between AR patients and healthy controls ( p > 0.05). Additionally, the dominant, additive and recessive genetic models of both SNPs were not associated with altered susceptibility to AR risk ( p > 0.05).

Conclusion

The results demonstrated that the ANRIL gene rs1333048 and rs10757278 polymorphisms might not be associated with susceptibility to AR in the Kurdish population of Kermanshah, Iran
Complete androgen insensitivity syndrome with Sertoli cell tumour in a 27-year-old married woman: a case report
Authors: Rasheed Mumini Wemimo , Idowu Najeem Adedamola , Adekunle Adebayo Ayoade , Olarewaju Joseph Olusola , Oduola-owoo Latifat Tunrayo , Odetayo Foluke Omolara , Omolade Felix Abiodun , Opeyemi Akinremi Tosin
Published: May 2023

Background

Androgen insensitivity syndrome is a rare X-linked disorder of sex development that results from mutations in the androgen receptors leading to failure of normal masculinization of the external genitalia in genetically male individuals. Our aim was to report this rare case of complete androgen insensitivity syndrome with Sertoli cell tumour, and our objective was to relate our experience on the challenges of the case and its successful management of the case.

Case presentation

We report a case of a 27-year-old married Nigerian woman who presented at the surgical outpatient of our centre with a complaint of primary amenorrhea. She had an attendant history of coital difficulty following marriage. Clinical examination revealed a female phenotype with left groin swelling. A diagnosis of complete androgen insensitivity syndrome was made following hormonal evaluation, advanced imaging studies, karyotyping, and cytogenetic study. She and her parents including her husband were duly counselled on the natural history and principles of treatment of this clinical condition. She subsequently had a bilateral orchidectomy, and she was placed on oestrogen replacement therapy as well as serial vaginal dilation. The outcome was satisfactory.

Conclusion

We reported a rare case of complete androgen insensitivity syndrome in a married woman. We documented our experience with successful conservative vaginal dilatation, which allowed satisfactory vaginal sexual intercourse.
The effect of addition of magnesium sulfate or dexamethasone to bupivacaine on the post-operative analgesic duration of ultrasound-guided quadratus lumborum block in open abdominal surgeries: a comparative study
Authors: Samir Ghada M. , Aboulella Sahar K. , Moussa Moussa E. , Saleh Mohamed A.
Published: May 2023

Background

The aim of this study was to assess the effect of addition of 500-mg magnesium sulfate (MgSo4) or 8-mg dexamethasone to bupivacaine in bilateral ultrasound-guided quadratus lumborum block (QLB), on the duration of post-operative analgesia, the patient’s hemodynamic parameters, the severity of post-operative pain, number of patients who required rescue analgesia, the total dose of pethidine given, the number of patients who maintained post-operative analgesia for 36 h, and the time to first ambulation. Sixty-six patients, 18 to 65 years old, with body weight 60–90 kg, scheduled to undergo elective open abdominal surgeries under general anesthesia, were randomly divided into three equal groups: the Bupivacaine-Magnesium QLB group (BM) patients, the Bupivacaine-Dexamethasone QLB group (BD) patients, and the Bupivacaine-Saline QLB group (BS) patients.

Results

The post-operative visual analogue scale (VAS) at rest and with movement was comparable between patients in the three groups: upon arrival to the post-operative care unit (PACU), in the PACU, and in the post-operative 2, 4, 6, 8, 12, 24, and 36 h. At 30 post-operative hours, the VAS at rest and with movement was statistically significantly lower in group BD 2 (0–4) and 2.75 (2–4.5) than in group BM 2.25 (0–4) and 3 (0–4.5), than in group BS 3.25 (3–4) and 4 (3.5–5), respectively, with P-value ˂ 0.001. Although 100% of patients in group BS received pethidine, versus 68.2% of patients in group BM and 63.6% of patients in group BD, with P-value 0.007, the cumulative total pethidine doses given, the duration of post-operative analgesia, and the number of patients who maintained post-operative analgesia for 36 h were comparable between the three groups with P-value 0.170, 0.239, and 0.231, respectively.

Conclusions

In bilateral ultrasound-guided QLB in open abdominal surgeries, the addition of dexamethasone or MgSo4 to bupivacaine reduced the VAS scores and the number of patients experiencing moderate pain at 30 post-operative hours, with fewer patients receiving pethidine and less cumulative total pethidine doses given, with dexamethasone showing better results.
Performance of externally reinforced CHS X-joints subjected to axial loads
Authors: Osman Ashraf , Gerguis Peter , Gaawan Sameh
Published: May 2023

Circular hollow sections (CHS) have evolved as the primary choice for the tubular lattice structures, due to their excellent mechanical properties and aesthetic appearance. However, enhancing the joints capacities in such structures poses as challenge to structural designer. Recent research addressed several external reinforcing schemes that can be utilized for strengthening CHS X-joints. Although each of these schemes was studied thoroughly, no collective study was conducted to compare between their efficiencies in enhancing CHS X-joints strengths and stiffnesses. This study focuses on evaluating the structural performance of these techniques relative to each other. The results showed that CHS X-joints strengthened using outer flanged pipe to confine brace-chord intersection achieved the highest strength and stiffness enhancement among the examined joints. Also, it proved that joints strengthened with single or double outer stiffeners yielded acceptable capacity enhancement with the advantages of easy fabrication and acceptable aesthetically appearance.
Retrieval of surface waves from high-speed-train-induced vibrations using seismic interferometry
Authors: Mi Binbin , Xia Jianghai , Xu Yixian , You Baiyang , Chen Yunfeng
Published: May 2023

Train traffic has recently been realized as a potential seismic source for imaging and monitoring shallow subsurface structures. High-speed trains usually move on viaducts and generate seismic wavefields through bridge piers. This kind of source is not randomly distributed in space and time and thus indicates the characteristic of self-correlation. We find that correlated sources of one high-speed train running over piers make time-delayed spurious signals in the crosscorrelation functions. The direct-wave interferometry with correlated sources is proposed and demonstrates that stacking the interferometric responses from high-speed trains with different speeds may reduce the spurious imprint of source self-correlations, but it cannot remediate the problem. The influence of the source wavelet can be eliminated by using cross coherence. Stationary-phase segment selection and stacking can reduce the bias generated by trains moving out of the stationary-phase zone of station pairs. The validity is demonstrated by using synthetic data with inline and out-of-line linear arrays. We apply the proposed scheme to field data with nine high-speed train events. Multimodal Rayleigh waves were retrieved and shallow shear-wave velocities were inverted from multimodal dispersion data in a range of 4–25 Hz. The results bring a novel approach for the imaging and monitoring of the shallow subsurface using high-speed-train-induced vibrations.
A platform for modular assembly and feeding of micro-organoids on standard Petri dishes
Authors: Nebuloni Federico , Morgan Joseph , Walsh Edmond J. , Cook Peter R.
Published: May 2023

Organoids grow in vitro to reproduce structures and functions of corresponding organs in vivo. As diffusion delivers nutrients over only ∼200 µm, refreshing flows through organoids are required to avoid necrosis at their cores; achieving this is a central challenge in the field. Our general aim is to develop a platform for culturing micro-organoids fed by appropriate flows that is accessible to bioscientists. As organs develop from layers of several cell types, our strategy is to seed different cells in thin modules (i.e. extra-cellular matrices in stronger scaffolds) in standard Petri dishes, stack modules in the required order, and overlay an immiscible fluorocarbon (FC40) to prevent evaporation. As FC40 is denser than medium, one might expect medium to float on FC40, but interfacial forces can be stronger than buoyancy ones; then, stacks remain attached to the bottom of dishes. After manually pipetting medium into the base of stacks, refreshing upward flows occur automatically (without the need for external pumps), driven mainly by differences in hydrostatic pressure. Proof-of-concept experiments show that such flows support clonal growth of human embryonic kidney cells at expected rates, even though cells may lie hundreds of microns away from surrounding fluid walls of the two immiscible liquids.
The insulin receptor regulates the persistence of mechanical nociceptive sensitization in flies and mice
Authors: Wang Yan , Lopez-Bellido Roger , Huo Xiaojiao , Kavelaars Annemieke , Galko Michael J.
Published: May 2023

Early phase diabetes is often accompanied by pain sensitization. In Drosophila, the insulin receptor (InR) regulates the persistence of injury-induced thermal nociceptive sensitization. Whether Drosophila InR also regulates the persistence of mechanical nociceptive sensitization remains unclear. Mice with a sensory neuron deletion of the insulin receptor (Insr) show normal nociceptive baselines; however, it is uncertain whether deletion of Insr in nociceptive sensory neurons leads to persistent nociceptive hypersensitivity. In this study, we used fly and mouse nociceptive sensitization models to address these questions. In flies, InR mutants and larvae with sensory neuron-specific expression of RNAi transgenes targeting InR exhibited persistent mechanical hypersensitivity. Mice with a specific deletion of the Insr gene in Nav1.8+ nociceptive sensory neurons showed nociceptive thermal and mechanical baselines similar to controls. In an inflammatory paradigm, however, these mutant mice showed persistent mechanical (but not thermal) hypersensitivity, particularly in female mice. Mice with the Nav1.8+ sensory neuron-specific deletion of Insr did not show metabolic abnormalities typical of a defect in systemic insulin signaling. Our results show that some aspects of the regulation of nociceptive hypersensitivity by the insulin receptor are shared between flies and mice and that this regulation is likely independent of metabolic effects.
The fission yeast cytokinetic ring component Fic1 promotes septum formation
Authors: Rossi Anthony M. , Bohnert K. Adam , Gould Kathleen L.
Published: May 2023

In Schizosaccharomyces pombe, septum formation is coordinated with cytokinetic ring constriction but the mechanisms linking these events are unclear. In this study, we explored the role of the cytokinetic ring component Fic1, first identified by its interaction with the F-BAR protein Cdc15, in septum formation. We found that the fic1 phospho-ablating mutant, fic1-2A, is a gain-of-function allele that suppresses myo2-E1, the temperature-sensitive allele of the essential type-II myosin, myo2. This suppression is achieved by the promotion of septum formation and required Fic1's interaction with the F-BAR proteins Cdc15 and Imp2. Additionally, we found that Fic1 interacts with Cyk3 and that this interaction was likewise required for Fic1's role in septum formation. Fic1, Cdc15, Imp2, and Cyk3 are the orthologs of the Saccharomyces cerevisiae ingression progression complex, which stimulates the chitin synthase Chs2 to promote primary septum formation. However, our findings indicate that Fic1 promotes septum formation and cell abscission independently of the S. pombe Chs2 ortholog. Thus, while similar complexes exist in the two yeasts that each promote septation, they appear to have different downstream effectors.
Regulation of anterior neurectoderm specification and differentiation by BMP signaling in ascidians
Authors: Roure Agnès , Chowdhury Rafath , Darras Sébastien
Published: May 2023

The most anterior structure of the ascidian larva is made of three palps with sensory and adhesive functions essential for metamorphosis. They derive from the anterior neural border and their formation is regulated by FGF and Wnt. Given that they also share gene expression profiles with vertebrate anterior neural tissue and cranial placodes, their study should shed light on the emergence of the unique vertebrate telencephalon. We show that BMP signaling regulates two phases of palp formation in Ciona intestinalis. During gastrulation, the anterior neural border is specified in a domain of inactive BMP signaling, and activating BMP prevented its formation. During neurulation, BMP defines ventral palp identity and indirectly specifies the inter-papilla territory separating the ventral and dorsal palps. Finally, we show that BMP has similar functions in the ascidian Phallusia mammillata, for which we identified novel palp markers. Collectively, we provide a better molecular description of palp formation in ascidians that will be instrumental for comparative studies.
Myc promotes polyploidy in murine trophoblast cells and suppresses senescence
Authors: Singh Vijay Pratap , Hassan Huzaifa , Deng Fengyan , Tsuchiya Dai , McKinney Sean , Ferro Kevin , Gerton Jennifer L.
Published: May 2023

The placenta is essential for reproductive success. The murine placenta includes polyploid giant cells that are crucial for its function. Polyploidy occurs broadly in nature but its regulators and significance in the placenta are unknown. We have discovered that many murine placental cell types are polyploid and have identified factors that license polyploidy using single-cell RNA sequencing. Myc is a key regulator of polyploidy and placental development, and is required for multiple rounds of DNA replication, likely via endocycles, in trophoblast giant cells. Furthermore, MYC supports the expression of DNA replication and nucleotide biosynthesis genes along with ribosomal RNA. Increased DNA damage and senescence occur in trophoblast giant cells without Myc, accompanied by senescence in the neighboring maternal decidua. These data reveal Myc is essential for polyploidy to support normal placental development, thereby preventing premature senescence. Our study, combined with available literature, suggests that Myc is an evolutionarily conserved regulator of polyploidy.
Propagation of Antidesma alexiteria and Syzygium caryophyllatum, two underexploited fruit plants in Sri Lanka: Effect of cutting types, potting media and auxin application
Authors: Somasiri Indi Vishaka , Herath Harshini , Sena Ratnayake Ratnayake Mudiyanselage Chula , Senanayake Seetha Priyanganie
Published: May 2023

Antidesma alexiteria and Syzygium caryophyllatum are two fruit species found in Sri Lanka of which the commercial development potential has not been fully identified. To bring these fruit species back into cultivation, establishment of suitable propagation systems for mass propagation is important. Therefore, this research was designed to identify suitable potting media, stem cutting types and requirement of auxin for successful vegetative propagation of the two fruit species. Softwood, semi-hardwood and hardwood cuttings of the fruit trees were planted in three potting media (M1 – topsoil, sand 1:1, M2 – topsoil, sand, compost 1:1:1 and M3 – topsoil, sand, coir dust 1:1:1) under two treatments; T1 – with plant growth reg­ulator indole-3-acetic acid (IAA) and T0 – controls without IAA. Each treatment was conducted with 15 replicates. The cuttings were planted in individual propagators and were kept in a net house of 50% shading under room temperature. Growth performance of the cuttings was monitored in regular intervals (every 28 days) for a period of six months. According to sprouting, survival, and growth performance, both softwood and semi-hardwood cuttings are suitable for vegetative propagation of A. alexiteria. The M3 medium showed 100% sprouting and survival but with respect to overall growth performance, the M1 medium was the most suitable for softwoods of A. alexiteria without auxin. Sprouting and survival of semi-hardwood cuttings were 100% with high values of growth parameters in M3 under T1 treatment. The M1 medium without auxin can be recommended for better performance of softwoods while M3with auxin is for semi-hardwoods of A. alexiteria. Softwoods, semi-hardwoods and hardwoods can be recommended for vegetative propagation S. caryophyllatum in M1 medium. Both softwood and semi-hardwood cuttings under T1 treatment expressed higher sprouting and survival percentages while semi-hardwood cuttings under T1 treatment have shown the highest sprouting and growth performance. Hence, semi-hardwood cuttings with auxin can be con­sidered as the best planting material for vegetative propagation of S. caryophyllatumwhile M1 is the best medium. The vegetative propagation of S. caryophyllatum and A. alexiteria through stem cuttings can be recommended as suitable mass propagation method for the purpose of commercialization.
Yes, she can do it!
Authors: Feferbaum Godoi Deborah , Amado Bahia Gama Marina
Published: May 2023

Ana Fontes, one of Brazil’s most powerful women according to Forbes, comes from a humble, hard- working background. Born in Alagoas, she had to overcome many challenges still faced by women in the country. A fruit of her efforts and confidence in the potential of female entrepreneurship, the Rede Mulher Empreendedora (RME) [Entrepreneurial Woman Network] was created to support women in their businesses. Since 2019, the Instituto RME (IRME), a nonprofit organization, is focused on the ELA PODE [She Can Do It] program, which is dedicated to empowering women in socioeconomic vulnerability. This teaching case discusses important topics related to Ana Fonte’s story and projects, such as: how to keep developing the network of entrepreneurs, multipliers and facilitators; and how to track the performance of the entrepreneurs who attend the courses in order to help them during and after the process.
Nutty World Brasil: desafios ao gerenciamento sustentável de uma rede de suprimentos
Authors: Gomes Rocha Gustavo , Russo Eduardo
Published: May 2023

A política corporativa de gestão de risco social representa uma adaptação dos gestores sobre os novos valores ambientais, morais e de governança social do mercado. Empresas que não se adequem a tais perspectivas podem encontrar dificuldades em se desenvolver. Nesse contexto, o caso narra um plano de expansão da Nutty World no Brasil que apresentou dilemas relacionados aos novos consumidores e na aquisição de maiores quantidades de insumos. A solução foi procurar uma nova fornecedora que apresentasse diluição dos custos. O plano, contudo, demonstrou dificuldades relacionadas aos critérios de gestão da qualidade e qualificação dos intermediários da cadeia de suprimentos. Dessa forma, o direcionamento dessas discussões ocorre para alunos de Graduação em Administração de Empresas com interesse no entendimento de gestão de risco social na cadeia produtiva e da qualidade de fornecedores.
O Plano (de negócio) de Beatriz: sonho bom ou dura realidade?
Authors: De Almeida Mendia Ana Beatriz , Lana Jailson , Beal Partyka Raul
Published: May 2023

A jovem Beatriz possui o sonho de ter sua independência econômica ao passo que participa ativamente para a prosperidade da região onde passou a maior parte de sua vida. Beatriz desenvolve a ideia de construir um hostel. Depois de efetuar uma longa pesquisa, elabora o plano operacional e a análise financeira. Beatriz começa a perceber alternativas a serem exploradas, como o porte adequado do empreendimento, construir ou alugar, uma estratégia de segmentação, entre outras. Apesar dos riscos, o sonho se aproxima da realidade. O objetivo do caso é promover uma análise que ajude Beatriz em sua tomada de decisão.
Precisamos desligar 500 pessoas: um caso de ensino sobre os desafios e conflitos do outplacement em massa
Authors: Moura da Silva Edson , Silva Correa Victor
Published: May 2023

Este caso descreve o processo de encerramento das atividades fabris de uma empresa do segmento de bebidas, aqui denominada Água Limpa, localizada na região metropolitana de Belo Horizonte, e as etapas que sucederam o comunicado de desligamento para mais de 500 profissionais. O caso é narrado na perspectiva de um profissional que atuava na área de Recursos Humanos, aqui denominado Pedro. O caso pode ser utilizado nas disciplinas de Gestão de Pessoas, Remuneração e Benefícios, Treinamento e Desenvolvimento, Comunicação, Planejamento, Carreira, Tomada de Decisão, nos cursos de graduação e pós-graduação.
Συστήνοντας τις ψηφιακές ανθρωπιστικές επιστήμες
Authors: Σιχάνη Άννα-Μαρία
Published: May 2023

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Διαδικτυακά παιχνίδια και ψηφιακές ανθρωπιστικές επιστήμες
Authors: Πετρίδης Πέτρος
Published: May 2023

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Τα ψηφιακά μέσα στην υπηρεσία της ιστορίας της τέχνης
Authors: Τενεκετζής Αλέξανδρος
Published: May 2023

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Brain-to-brain communication during musical improvisation: a performance case study
Authors: Ramírez-Moreno Mauricio A. , Cruz-Garza Jesús G. , Acharya Akanksha , Chatufale Girija , Witt Woody , Gelok Dan , Reza Guillermo , Contreras-Vidal José L.
Published: May 2023

Understanding and predicting others' actions in ecological settings is an important research goal in social neuroscience. Here, we deployed a mobile brain-body imaging (MoBI) methodology to analyze inter-brain communication between professional musicians during a live jazz performance. Specifically, bispectral analysis was conducted to assess the synchronization of scalp electroencephalographic (EEG) signals from three expert musicians during a three-part 45 minute jazz performance, during which a new musician joined every five minutes. The bispectrum was estimated for all musician dyads, electrode combinations, and five frequency bands. The results showed higher bispectrum in the beta and gamma frequency bands (13-50 Hz) when more musicians performed together, and when they played a musical phrase synchronously. Positive bispectrum amplitude changes were found approximately three seconds prior to the identified synchronized performance events suggesting preparatory cortical activity predictive of concerted behavioral action. Moreover, a higher amount of synchronized EEG activity, across electrode regions, was observed as more musicians performed, with inter-brain synchronization between the temporal, parietal, and occipital regions the most frequent. Increased synchrony between the musicians' brain activity reflects shared multi-sensory processing and movement intention in a musical improvisation task.
Oral cavity health and remedy options to stimulate epithelization of oral mucosa
Authors: Boitsaniuk Svitlana , Chorniy Sofiia , Manashchuk Nadia , Chornij Natalia , Pohoretska Khrystyna , Patskan Lyudmula , Levkiv Mariana
Published: May 2023

Oral mucosa is an inner lining of oral cavity, which maintains different functions including protection of epithelial integrity. Pathology of oral mucosa can develop in response to the action of pathogenic microorganisms, viruses, and various traumatic factors; it can be a result of systemic pathology of a patient as well. Pain and discomfort usually accompanies such conditions leading to decrease of patient wellbeing. The basis of the pharmacological regulation of the regeneration process is the stimulation of wound healing.

The aim is to summarize and discuss the spectrum of remedy options that are used to stimulate epithelization of oral mucosa. The overall goal of the paper is to provide full and comprehensive information for dentists and their patients about medicament variety, ways of theirs application and dosage.

Methods. Relevant literature from MEDLINE (PubMed), Google Scholar, and in open access journals which are published by Elsevier was selected using the following key words «oral mucosa», «epithelization», and «remedy» were used in various combinations by the year of 2023. In total there were found 48 papers. To the selected scientific papers we applied the inclusion and exclusion criteria to choose the relevant ones.

Conclusions. A significant number of drugs for the treatment of inflammatory processes in the oral cavity are available nowadays on dental market. Numerous studies substantiates the effectiveness of their use in dentistry. Therefore, when choosing pharmacological drugs, preference is given to drugs with a complex effect, which locally affect various links of the pathogenetic mechanism of the occurrence of diseases and do not disturb human wellbeing.
Decisiones durante la transferencia de la formación permanente del profesorado de Matemáticas.
Authors: Pamies-Berenguer Marcial , Gomariz-Vicente María Ángeles , Cascales-Martínez Antonia
Published: May 2023

El concepto de transferencia de la formación permanente del profesorado se entiende como la medida en la que éste es capaz de generalizar los aprendizajes adquiridos en un contexto formativo a su puesto docente. En dicho proceso de generalización, la identificación de escenarios de aplicación y las decisiones sobre la aplicación adoptadas juegan un papel relevante. El objetivo de la investigación es explorar las asociaciones entre los factores condicionantes de la transferencia y las actividades de identificación de escenarios de aplicación y la toma de decisiones sobre ésta en el contexto de los programas formativos del profesorado no universitario de Matemáticas. Los participantes fueron 344 docentes en activo. Se determinaron dos modelos logísticos multinomiales que permitieron estudiar las asociaciones indicadas mediante el análisis de los odss ratio. Los resultados mostraron que el factor Diseño y desarrollo de la formación se asoció positivamente tanto con la capacidad de identificar situaciones de aplicación como con la decisión de realizar una aplicación efectiva. Por su parte, los factores Seguimiento de la institución formadora y Locus de control externo se asociaron positivamente con la capacidad de identificación de escenarios de aplicación, mientras que la asociación resultó negativa para el factor Feedback de los estudiantes y familias. En conclusión, se han identificado dimensiones sobre las que diseñar acciones de intervención para mejorar la transferencia de la formación permanente del profesorado de matemáticas.
influencia del diseño en el branding de empresas medianas y grandes de Manizales, Colombia
Authors: Alzate Sanz Jaime Eduardo , Orozco Toro Jaime Alberto
Published: May 2023

Las investigaciones que relacionan al diseño con el branding se han enfocado en la identidad o laimagen, lo cual ha generado espacios de discusión específicos; por esta razón, se hace necesario profundizar de forma más amplia y articulada sobre los vínculos existentes entre estas dos áreas, en el ámbito empresarial. El objetivo de este artículo es analizar el papel del diseño en el branding de empresas medianas y grandes de la ciudad de Manizales (Colombia). Se aborda el diseño como disciplina que se conecta con la construcción de marca corporativa, a través de diferentes actividades inherentes a la comunicación de las empresas. El método está basado en la realización de entrevistassemiestructuradas a nueve profesionales vinculados con las empresas objeto de estudio y a tres expertosdel área del branding. Los resultados y conclusiones, que se extrajeron de esta investigación, permitieron evidenciar la influencia del diseño en las diferentes acciones enfocadas en el branding de las empresas objeto de estudio. La estrategia, la gestión de la comunicación, la estructuración de sistemas identitarios y los procesos de investigación e innovación son algunos de los campos en los cuales hay conexión con el diseño, por lo cual, se concluye que esta área de conocimiento de carácter interdisciplinar está presente de forma transversal en la proyección empresarial.
Como os espaços públicos abertos podem contribuir para a promoção da atividade física?
Authors: Rech Cassiano Ricardo , Pazin Joris , Rodrigues Eduardo Quieroti , Paiva Neto Francisco Timbó de , Knebel Margarethe Thaisi Garro , Coco Thamires Gabrielly dos Santos , Fermino Rogério César
Published: May 2023

Espaços públicos abertos (EPA) são equipamentos que promovem o direito à recreação e à saúde. O objetivo deste ensaio é apresentar reflexões e evidências sobre como esses espaços contribuem para a promoção da atividade física (AF). Compreender como o acesso (proximidade/distância), a quantidade e diversidade, as condições do entorno e internas dos locais (qualidade, estrutura, estética, segurança), podem afetar o uso dos EPA é fundamental para ações da gestão pública. Pensar o uso do EPA para além da prática de AF, reconhecendo seus benefícios sociais, econômicos e culturais pode ser fundamental para diminuir as iniquidades de acesso a esses locais. Ações e demandas relacionadas aos EPA são intersetoriais, multiprofissionais e interdisciplinares, necessitando com isso envolvimento e comprometimento político, acadêmico e comunitário, a fim de promover AF.
Simultaneous Dimension Reduction and Variable Selection for Multinomial Logistic Regression
Authors: Wen Canhong , Li Zhenduo , Dong Ruipeng , Ni Yijin , Pan Wenliang
Published: May 2023

Multinomial logistic regression is a useful model for predicting the probabilities of multiclass outcomes. Because of the complexity and high dimensionality of some data, it is challenging to fit a valid model with high accuracy and interpretability. We propose a novel sparse reduced-rank multinomial logistic regression model to jointly select variables and reduce the dimension via a nonconvex row constraint. We develop a block-wise iterative algorithm with a majorizing surrogate function to efficiently solve the optimization problem. From an algorithmic aspect, we show that the output estimator enjoys consistency in estimation and sparsity recovery even in a high-dimensional setting. The finite sample performance of the proposed method is investigated via simulation studies and two real image data sets. The results show that our proposal has competitive performance in both estimation accuracy and computation time.

History: Accepted by Andrea Lodi, Area Editor for Design & Analysis of Algorithms–Discrete.

Funding: This work was supported by the National Natural Science Foundation of China [Grants 71991474, 12171449, 11801540, and 12071494] and the Natural Science Foundation of Anhui Province [Grant BJ2040170017].

Supplemental Material: The online appendix is available at https://doi.org/10.1287/ijoc.2022.0132 .
On the Nature of (Jump) Skewness Risk Premia
Authors: Orłowski Piotr , Schneider Paul , Trojani Fabio
Published: May 2023

Market skewness risk is priced, but the components of its premium are not fully understood. We propose new trading strategies decomposing the skewness risk premium into jump and leverage effect components, and we analyze the skewness risk premia in the market for S&P 500 index options. We find that the skewness premium is higher when markets are closed than during trading hours, consistently with uncertainty resolution patterns by non-U.S investors; that it increases after left-tail market events; and that it is distinct from the variance premium. Moreover, during trading hours, the skewness premium is dominated by priced jump risk.

This paper was accepted by Kay Giesecke, finance.

Funding: P. Orłowski acknowledges financial support from the Doc.Mobility program of the Swiss National Science Foundation [Project P1TIP1_161875 “Option portfolio returns and dispersion”]. P. Schneider acknowledges financial support from the Swiss National Science Foundation [Projects 169582 “Model-free asset pricing” and 189086 “Scenarios”]. F. Trojani and P. Orłowski acknowledge financial support from the Swiss National Science Foundation [Project 150198 “Higher order robust resampling and multiple testing methods”] and the Swiss Finance Institute [Project “Term structures and cross-sections of asset risk premia”]. F. Trojani gratefully acknowledges support from the AXA Chair in Socioeconomic Risks of Financial Markets at the University of Turin.

Supplemental Material: The data files and online appendices are available at https://doi.org/10.1287/mnsc.2023.4734 .
Impoliteness in Jeremy Clarkson’s humor in the tv series Top Gear
Authors: Elkholy Elkholy , Ahsani Nizam
Published: May 2023

This research was conducted  to observe impoliteness strategies employed by Jeremy Clarkson in his humor in the TV Series Top Gear with the intention to unveil which strategy he utilized most and elucidate the reason upon the most and least occurring impoliteness strategies. The present research utilizes Culpeper’s (1996) model of impoliteness super strategies as the main framework to identify, analyze, and elaborate the research data. Other theories related to impoliteness such as face-threatening act and politeness was also utilized to assist the analysis process. The result of the research revealed that negative impoliteness strategy was the most commonly used strategy through which Jeremy Clarkson delivers his humor. Contrary to the withhold politeness strategy which accounted for the least occurring strategy. The explanation upon the result to be the way they are could be referred back to Jeremy Clarkson’s main intentions of uttering impolite remarks—in an effort to amuse the audience and keep the show entertaining.
Markov Chain Rainfall Probability Model and Rainy Season Length in Kendrapara District, Odisha for Efficient Crop Management Strategies
Authors: Verma Om Prakash , Sethi Ranu Rani , Nayak Ashok Kumar , Manikandan Narayanan , Pradhan Sanatan , Jha Ankita , Jena Susanta Kumar , Patra Prasanta Kumar
Published: May 2023

Systematic information on rainfall patterns and distribution is essential for crop selection, adopting improved agronomic practices, designing rainwater harvesting structures, and conserving rainwater. This study analyzed the probabilities of rainfall occurrence to know the rainfall onset, withdrawal, and rainy season length for different blocks of Kendrapara district, Odisha. The rainfall analysis showed that the kharif season shares 75-78% of annual rainfall with July and August being the wettest. Seasonal rainfall showed a significant increase during kharif season while the decreasing trend was observed during the rabi and summer seasons. Markov chain analysis showed that the weekly probability for 20-mm rainfall and consecutive two weeks is more than 70% during SMW 25-38. During the June-October period, assured rainfall at 80% probability is greater than 800 mm in four blocks, while in other blocks it ranged between 610-779 mm. Assured rainfall during the rabi and summer season is uncertain, however, a 105-126 mm rainfall is received in May in many blocks, useful for summer ploughing and green manure crops. Rainy season length analysis at an 80% probability level revealed that only in 14-16 weeks’ rain occurs, thereby, only short-duration paddy can be grown with lower risk. By utilizing October rainfall and conserved soil moisture, short-duration pulses/oilseeds could be grown in all the blocks. However, kharif paddy must be sown/transplanted at the optimum time
Mineralogical Study of Respirable Dust in Artisanal SmallScale Quarries of Misisi Compound, Lusaka, Zambia
Authors: Mutambo Victor , Munchini Catherine
Published: May 2023

Misisi compound in Lusaka is characterized by artisanal small scale quarrying activities which are often dusty in nature and prone to hazards. This study reports respirable dust concentration and the mineralogical composition of rocks in the workplace. Dust sampling was carried out with the help of gravimetric samplers at five quarries. Respirable dust samples were collected during digging, chiselling, crushing, and loading sites. The results of the sampled dust indicated high levels of respirable dust at all five quarry crushing sites. For example, based on Time Weighted Average (TWA), the respirable dust concentration at the crushing site was recorded as 12.75 mg/m3 at quarry#1 compared to the Maximum Allowable Concentration (MAC) of 5 mg/m3 of Occupational Safety and Health Administration (OSHA). The results of mineralogical testing and analyses revealed that marble was the common rock type that was being mined by most of the ASMs in the studied area. Based on the point count data analysis, marble contained 98% CaCO3 and 2% SiO2.
Trabalho Docente no Contexto da Expansão Universitária
Authors: Pinheiro Francisco Pablo Huascar Aragão , Santana Antonio Renan , Melo Lorena Aélio de , Rodrigues Cristina Silmara Duarte , Camelo Elysne , Cunha Esthela Sá , Aguiar Hellyne Maria Teles , Alves José Jocélio Paulino
Published: May 2023

As reformas neoliberais promoveram transformações no ensino superior. Nesse contexto, diversas instituições aderiram ao Programa de Apoio a Planos de Reestruturação e Expansão das Universidades Federais (REUNI). Isto, contudo, se deu sem as contrapartidas necessárias. O propósito da investigação, assim, foi compreender os impedimentos ao poder de agir de docentes que atuavam em um campus estruturado a partir do REUNI. Adotou-se o referencial da Clínica da Atividade. Participaram do estudo três docentes, duas mulheres e um homem, que atuavam em cursos de graduação e pós-graduação. Em uma perspectiva histórico-desenvolvimentista, foram realizadas entrevistas a partir de imagens que representavam elementos do contexto laboral. Utilizou-se análise construtivo-interpretativa. Dentre os resultados, viu-se intensificação do trabalho promovida pela atuação em cursos de pós-graduação e por atividades invisibilizadas; desprofissionalização associada ao desempenho de atividades alheias ao fazer docente; estrutura física inadequada; carga de trabalho elevada; pressões para o cumprimento de prazos; uso do espaço doméstico para o trabalho; e invasão do tempo livre. Os achados podem nortear ações de promoção da saúde docente e dar balizas para a discussão sobre as melhorias dos contextos de trabalho.
Implicações da Pandemia para a Psicologia nas Políticas Públicas
Authors: Costa Pedro Henrique Antunes da , Meneses Amanda Figueiredo Falcomer , Silva Júnior Antonio Juvenal da , Pinto Débora Ferreira Couto , Oliveira João Gabriel Carvalho Araújo Mello de , Carvalho Marília Batista , Corrêa Otto Leone , Andrade Soraya Souza de , Mendes Kíssila Teixeira , Ronzani Telmo Mota
Published: May 2023

O artigo objetivou identificar e analisar desafios e potencialidades no trabalho de psicólogas(os) nas políticas públicas brasileiras na conjuntura pandêmica. É um estudo exploratório-descritivo de abordagem mista. A coleta de dados foi realizada por meio de questionário virtual com 123 psicólogas(os) que trabalhavam nas políticas públicas no país. A análise se deu a partir da extração de medidas de tendência central e pela Análise de Conteúdo temática, em um diálogo da psicologia com a tradição marxista. Os resultados apontaram para os efeitos deletérios objetivos e subjetivos do sucateamento das políticas às(aos) profissionais, bem como o tolhimento de suas práticas. Por outro lado, também apontaram algumas potencialidades que contradizem a si próprias(os) e à realidade. Fica a premência de responsabilização do Estado em fornecer melhores condições de trabalho e fortalecer as políticas públicas para o enfrentamento à pandemia, assim como a necessidade de reflexão e transformação da psicologia e sua práxis.
Função de Cuidar na Educação Infantil: Contribuições de Grupos de Discussão de Trabalho com Educadoras
Authors: Sehn Amanda Schöffel , Lopes Rita De Cassia Sobreira
Published: May 2023

As educadoras que atuam na Educação Infantil participam da subjetivação de bebês e crianças pequenas, o que pode ser extremamente exigente. Nesse sentido, este estudo teve como objetivo oferecer um espaço de escuta para educadoras, com vistas a refletir sobre os desafios da função de cuidar de bebês e crianças bem pequenas na Educação Infantil. Foram realizadas duas edições de um grupo de discussão de trabalho, nas quais participaram cinco educadoras. O material produzido no grupo de discussão de trabalho, juntamente com relatos discutidos em supervisão, foi analisado qualitativamente, a partir de análise temática indutiva. Os resultados evidenciam que o cuidado exige presença, previsibilidade, intimidade e sensibilidade, o que, muitas vezes, é solicitado pelos próprios bebês/crianças que convocam o adulto. Entretanto, responder a essas demandas de forma individualizada num ambiente coletivo pode trazer desconforto, mal-estar e angústia. O grupo de discussão de trabalho oportunizou às educadoras tomarem consciência de como se utilizavam, por vezes, de um estilo de cuidado mais mecanizado e controlador, de forma a se protegerem dessas demandas. Em síntese, o bebê/criança desacomoda o adulto e o convoca a (re)pensar sobre seu fazer, apontando a importância de espaços de escuta e reflexão aos profissionais da educação.
Terapia Cognitivo-Comportamental em Grupo: Estratégia de Psicoeducação com Estudantes de Enfermagem
Authors: Souza Deise Coelho de , Rossato Lucas , Zanini Marta Regina Gonçalves Correia , Scorsolini-Comin Fabio
Published: May 2023

Este estudo teve por objetivo apresentar os resultados de um grupo psicoterápico psicoeducativo desenvolvido junto a estudantes de Enfermagem. Foram realizados seis encontros com cinco estudantes de uma universidade pública do Estado de São Paulo. Os encontros foram audiogravados, transcritos e submetidos à análise temático-reflexiva. Os resultados encontrados permitiram a construção de cinco categorias temáticas: (1) Desafios da adaptação ao ensino superior; (2) Concepções sobre saúde mental na universidade; (3) Autocuidado e equilíbrio entre a vida universitária e pessoal; (4) Relações interpessoais e vida universitária; (5) Perspectivas e expectativas sobre a formação. O processo de integração à universidade requer mobilização cognitiva, afetiva e social, sendo que as relações com os pares, professores e familiares foram destacadas como importantes para essa adaptação. As participantes destacaram conhecer a importância do cuidado em saúde mental, mas admitiram dificuldades de promoverem o autocuidado. O espaço grupal foi utilizado como ambiente de escuta, estabelecimento de vínculo e autocuidado. Os grupos psicoeducativos demonstraram ser importantes para a construção de estratégias de enfrentamento e um espaço para o acolhimento de demandas que emergem nessa etapa do desenvolvimento.