bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of ABCB1 3435C>T polymorphism on methotrexate safety in patients with psoriasis
Authors: Kubanov Alexey A. , Asoskova Anastasiia V. , Zastrozhin Michael S. , Sozaeva Zhannet A. , Sychev Dmitry A.
Published: February 2023

Background. Methotrexate is a highly effective systemic treatment for moderate to severe psoriasis, but drug toxicity may limit its use. Recent evidence suggests that it is necessary to take into account the individual characteristics of methotrexate pharmacokinetics, which are determined by the presence of polymorphisms of genes encoding methotrexate carrier proteins, to predict the risk of methotrexate-induced toxicity.
Aims. The research aim is the assessment of associations of ABCB1 rs1045642 (3435CT) polymorphism with methotrexate safety for the patients with moderate and severe forms of psoriasis.
Materials and methods. The study included 75 patients diagnosed with psoriasis treated with methotrexate during 21 day. Data on adverse drug reactions were collected using a clinically structured questionnaire, complete and biochemical blood tests, and urinalysis. The severity of adverse drug reactions was assessed using visual analog scales and the CTCAE toxicity scale. The severity of gastrointestinal ADR was assessed using the GSRS questionnaire. Genotyping was carried out by real-time PCR.
Results. The gastrointestinal toxicity was detected in 38 patients (50.67%). The mean GSRS score was 7.97 9.18. Analysis of differences in the incidence of adverse drug reactions showed the presence of statistically significant differences in the frequency of adverse drug reactions in the gastrointestinal tract: the toxic effect of methotrexate was more often observed in carriers of the T allele of the ABCB1 rs1045642 polymorphism (3435CT), (CC 2 (14.3%), TC 18 (52.9%), TT 18 (66.7%), p = 0.006). Binomial regression demonstrated the presence of a statistically significant effect of the rs1045642 SNP polymorphism of the ABCB1 gene on the incidence of ADR from the gastrointestinal tract (OR = 8.64, p = 0.008).
Conclusions. An association of ABCB1 rs1045642 SNP with the safety of gastrointestinal methotrexate therapy in patients with moderate and severe forms of psoriasis was revealed. The data obtained can be used to personalize the prescription of methotrexate to patients with psoriasis.
Clindamycin/benzoyl peroxid gel in mild-to-moderate acne
Authors: Olisova Olga Yu. , Anpilogova Ekaterina M.
Published: February 2023

Acne is a widespread inflammatory disease affecting the pilosebaceous follicles of the skin. It mostly affects teenagers and, in most cases, clinical healing occurs as patients grow up. However, 1040% of adults may have acne tarda. Due to the fact that face is one of the favorite locations of rashes, acne significantly worsens the quality of life, as a result of which patients develop social phobia, anxiety disorders, depression and even suicidal ideas, which requires a personalized approach to prescribing highly effective treatment. According to world recommendations, regardless of the severity of acne, almost all patients are shown the use of local remedies. In our pharmaceutical market, the choice of this group of drugs is quite limited. However, in September 2022, a new drug appeared in the arsenal of Russian dermatologists, which is a combination of benzoyl peroxide and clindamycin. This review presents the accumulated experience of almost 20 years of foreign colleagues who have been successfully using a combination of benzoyl peroxide and clindamycin in the treatment of mild-to-moderate acne.
Abordagem geral da vasculite por IgA
Authors: Barenco Bettina Pires de Mello , Barenco Bárbara Pires de Mello , Costa Mariana Zamprogno da , Azevedo Christianne Terra de Oliveira
Published: February 2023

Objetivo: Analisar as características da Vasculite associada à imunoglobulina A (VIgA). Revisão bibliográfica: A VIgA, anteriormente denominada como Púrpura de Henoch-Schönlein, é uma vasculite de imunocomplexos que afeta principalmente pequenos vasos e se apresenta de forma aguda. É a forma mais comum de vasculite infantil, com uma incidência de 3 a 27 casos por 100.000 crianças e se caracteriza pela tétrade clássica de púrpura palpável, artrite ou artralgia, hematúria e dor abdominal. As complicações agudas da VIgA, as mais frequentes são aquelas relacionadas ao sistema gastrointestinal, incluindo sangramento, intussuscepção e perfuração intestinal como as mais graves. A complicação crônica mais grave é a nefropatia por IgA. Considerações finais: A vasculite por IgA é uma vasculite não trombocitopênica de pequenos vasos que se apresenta de maneira aguda, caracterizada pela deposição de IgA. A história de infecção do trato respiratório superior ou de exposição a antígenos de certos alimentos, insetos, drogas ou vacinas geralmente pode ser encontrada antes do início da doença. Esta é uma vasculite normalmente benigna, cujo tratamento perpassa por sintomáticos e repouso, sendo necessária a administração de corticóides somente nas formas mais graves ou refratárias.
Myeloid sarcoma of the thoracic spine: A case report
Authors: Patel Tarika Deepak , Uzoaru Ikechukwu , Sutton Bradley P. , Arnold Paul M.
Published: February 2023

Background:

Myeloid sarcoma is an uncommon malignant neoplasm that typically arises at extramedullary sites and is associated with a diagnosis of acute myeloid leukemia. While myeloid sarcoma can involve any organ, central nervous system involvement is rare, particularly in the adult population.

Case Description:

An 87-year-old female presented with progressive paraparesis of 5 days’ duration. The magnetic resonance imaging (MRI) revealed an epidural tumor from T4 to T7 with cord compression. When she underwent a laminectomy for tumor resection, the pathology revealed a myeloid sarcoma with monocytic differentiation. Although she improved postoperatively, she elected to pursue hospice care and expired 4 months later.

Conclusion:

Myeloid sarcoma is an uncommon malignant spinal neoplasm rarely seen in adults. For this 87-year-old female, MRI-documented cord compression warranted decompressive surgery. Although this patient did not opt for adjuvant therapy, other patients with such lesions may undergo additional chemotherapy or radiation therapy. Nevertheless, optimal management for such malignant tumor is still undefined.
Fractionation of Vipera berus berus Snake Venom and Detection of Bioactive Compounds Targeted to Blood Coagulation System
Authors: Iskandarov Eldar , Gryshchuk Volodymyr , Platonov Oleh , Kucheriavyi Yevhenii , Slominskyi Oleksandr , Stohnii Yevhenii , Vartanov Volodymyr , Chernyshenko Volodymyr
Published: February 2023

Introduction. The performed research focused on a search for new biologically active compounds acting on blood coagulation system proteins and cells. To achieve this goal, we fractionated Vipera berus berus snake venom and studied the action of the separated fractions on human blood plasma, fibrinogen, platelets or red cells. Methods. Crude venom was fractionated using ion-exchange chromatography. Protein composition of fractions was studied using SDS-PAGE. The ability of fractions to prolong or initiate blood plasma clotting was studied using the prothrombin time test with thromboplastin. Fibrinogen-specific proteases were detected using enzyme-electrophoresis. Action on red cells was estimated using the hemolysis test. Aggregometry was used for the detection of action on platelets. All experiments in this study were performed in vitro. Results. We obtained fractions containing phospholipase and a protease that is able to hydrolyze fibrinogen, leading to the loss of its ability to polymerize and to maintain platelet aggregation. Conclusion. Further purification and study of these components can be a promising research direction for biotechnological as well as for biomedical use.
Penggunaan Ruang dan Dampak Aktivitas Home-based Enterprise terhadap Kondisi Lingkungan Sekitar di Kawasan Permukiman Watugong – Kerto, Ketawanggede, Malang
Authors: Kirana Nur Annisa
Published: February 2023

Kota Malang menjadi salah satu kota yang setiap tahunnya terdapat berbagai pendatang dari berbagai daerah yang bertujuan untuk melanjutkan studinya di Kota Malang. Hal tersebut menyebabkan Kota Malang menajdi semakin berkembang terutama pada kawasan permukiman. Perkembangan kawasan yang paling dekat dengan kampus-kampus pilihan dapat menimbulkan berbagai macam sektor informal Home-Based Enterprise. Keberadaan sektor informal yaitu HBE tersebut telah menjadi salah satu sumber pendapatan dan pekerjaan pada kehidupan masyarakat di sekitar kampus-kampus pilihan yang ada di Kota Malang. Salah satu kawasan permukiman yang menimbulkan berbagai macam HBE yang semakin berkembang tersebut ialah kawasan Watugong – Kerto yang terletak diantara Universitas Brawijaya dan UIN Malik Ibrahim. Penelitian ini bertujuan untuk mengidentifikasi keberadaan dan mengetahui dampak dari aktivitas HBE dalam spasial seperti penggunaan ruang dan kondisi lingkungan sekitar. Penelitian ini menggunakan metode deskriptif kualitatif dengan pengumpulan data yang dilakukan melalui observasi langsung di lapangan. Hasil pada penelitian ini yaitu didapatkan tiga strategi yang diimplementasikan oleh masyarakat sekitar yang mengalihfungsikan tempat tinggalnya menjadi HBE, yaitu dengan pembagian ruang, perluasan ruang, dan pergeseran ruang. Namun, Home-Based Enterprise juga berdampak negatif pada kenyamanan penggunaan jalan karena keberadaan  HBE seringkali menimbulkan hambatan samping pada ruas jalan serta menghambat kelancaran pergerakan masyarakat yang berkendara maupun yang berjalan kaki.
Stabilizing an all-aqueous two-phase system using oil-in-water droplets to mimic double emulsions
Authors: Douliez J-Paul
Published: February 2023

The production of water-in-water emulsion droplets, the coalescence of which is prevented by adding oil-in-water micrometric droplets is reported. Hexadecane (O) and cetyl trimethyl ammonium bromide (CTAB) were added to a W/W emulsion made of dextran (Dex)-enriched droplets in a Polyethyleglycol (PEG)-enriched continuous phase and the mixture was further sonicated. Using Nile red to label the oil droplets afforded to observe their presence at the surface of Dex droplets (5 µm) allowing stabilizing them, preventing coalescence of the W/W emulsion, and mimicking W/O/W double emulsions. Addition of sulfate derivative of Dextran (DexSulf) allowed stable droplets of slightly larger diameter. By contrast, addition of carboxymethyl Dextran (CMDex) destabilized the initial aqueous double-like emulsion, yielding sequestration of the oil droplets within the Dex-rich phase. Interestingly, addition of DexSulf to that unstable emulsion re-yielded stable droplets. Similar findings (destabilization) were obtained when adding sodium dodecyl sulfate (SDS) to the initial double-like emulsion, which reformed stable droplets when adding positively charged Dextran (DEAEDex) derivative. The use of fluorescently (FITC) labelled derivatives of Dextran (Dex, CMDex, DEAEDex and DexSulf) allowed to follow their position within, out or at the interface of droplets in the above-mentioned mixtures. These findings are expected to be of interest in the field of materials chemistry.
Outlier-Based Domain of ApplicabilityIdentification for Materials PropertyPrediction Models
Authors: Panapitiya Gihan , Saldanha Emily
Published: February 2023

Machine learning models have been widely applied for material property prediction. However, practical application of these models can be hindered by a lack of information about how well they will perform on previously unseen types of materials. Because machine learning model predictions depend on the quality of the available training data, different domains of the material feature space are predicted with different accuracy levels by such models. The ability to identify such domains enables the ability to find the confidence level of each prediction, to determine when and how the model should be employed depending on the prediction accuracy requirements of different tasks, and to improve the model for domains with high errors. In this work, we propose a method to find domains of applicability using a large feature space and also introduce analysis techniques to gain more insight into the detected domains and subdomains.
Prediction of enzyme catalysis by computing reaction energy barriers via steered QM/MM Molecular Dynamics Simulations and Machine Learning
Authors: Platero-Rochart Daniel , Krivobokova Tatyana , Gastegger Michael , Reibnegger Gilbert , Sánchez-Murcia Pedro Alejandro
Published: February 2023

The prediction of enzyme activity in a general extend is maybe one of the main challenges nowadays in catalysis. Computer-assisted methods have been proven to be able to simulate the reaction mechanism at the atomic level of detail. However, these methods tend to be expensive to be used in a large scale as it is needed in protein engineering campaigns. To alleviate this situation, machine learning methods can help in the generation of predictive-decision models. Herein we train different regression algorithms for the prediction of the reaction energy barrier of the rate-limiting step of the hydrolysis of mono-(2-hydroxyethyl)terephthalic acid by the MHETase of Ideonella sakaiensis. As training data set we use steered QM/MM MD simulation snapshots and their corresponding pulling work values. We have explored three algorithms together with three chemical representations. As outcome, our trained models are able to predict pulling works along the steered QM/MM MD simulations with a mean absolute error below 3 kcal mol-1 and a score value above 0.90. More challenging is the prediction of the energy maximum with a single geometry. Whereas the use of the initial snapshot of the QM/MM MD trajectory as input geometry yields a very poor prediction of the reaction energy barrier, the use of an intermediate snapshot of the former trajectory brings the score value above 0.40 with a low mean absolute error (ca. 3 kcal mol-1). Altogether, in this work we have faced some initial challenges of the final goal of getting an efficient workflow for the semi-automatic prediction of enzyme-catalyzed energy barriers and catalytic efficiencies.
Topological Isomerism in Three-Dimensional Covalent Organic Frameworks
Authors: Liu Yaozu , Li Jingwei , Lv Jia , Wang Zitao , Suo Jinquan , Reng Junxia , Liu Jianchuan , Liu Dong , Wang Yujie , Valtchev Valentin , Qiu Shilun , Zhang Daliang , Fang Qianrong
Published: February 2023

Although isomerism is a typical and significant phenomenon in organic chemistry, it is rarely found in covalent organic framework (COF) materials. Herein, for the first time, we report a controllable synthesis of topological isomers in three-dimensional COFs via a distinctive tetrahedral building unit under different solvents. Based on this strategy, both isomers with dia or qtz net (termed JUC-620 and JUC-621) have been obtained, and their structures are deter-mined by combining powder X-ray diffraction and transmission electron microscopy. Remarkably, these architectures show a dis-tinct difference in their porous features, e.g., JUC-621 with qtz net exhibits permanent mesopores (up to ~ 2.3 nm) and high surface area (~ 2060 m2 g-1), which far surpasses those of JUC-620 with dia net (pore size of ~1.2 nm and surface area of 980 m2 g-1). Further-more, mesoporous JUC-621 can remove dye molecules efficiently and achieves excellent iodine adsorption (up to 6.7 g g-1), which is 2.3 times that of microporous JUC-620 (~2.9 g g-1). This work thus provides a new way for constructing COF isomers and promotes structural diversity and promising applications of COF mate-rials.
The NETosis phenomena as a functional features of peripheral blood neutrophils and its role in the pathogenesis of infections and oncological diseases: A review
Authors: Glukhareva Anastasia E. , Afonin Grigory V. , Melnikova Angelika A. , Grivtsova Lyudmila Yu. , Kolobaev Ilya V. , Ivanov Sergei A. , Kaprin Andrei D.
Published: February 2023

The review is devoted to the analysis of the mechanism of NETosis and the formation of extracellular traps by neutrophils. Neutrophil traps are DNA strands, histones and proteins that are involved in autoimmune diseases, COVID-19, as well as in the pathogenesis of other non-communicable diseases. Based on the literature data, the role of NETosis in the development oncological diseases is analyzed. Two types of neutrophils have been characterized: low-density neutrophils and high-density neutrophils. In particular, the significance of this phenomenon in the progression and metastasis of the cancer. A detailed study of this issue will be useful both from a fundamental standpoint regarding the disclosure of the mechanisms of the metastatic cascade, and from a practical point of view for the development of new immunotherapeutic approaches in the treatment of metastatic tumors.
Combination of microspheres and gadoteridol for the determination of non-target ovarian embolization during uterine artery embolization. A case series
Authors: Sharafutdinov Bulat M. , Ryzhkin Sergey A. , Galim'yanov Diaz A. , Gaziev Edgar A.
Published: February 2023

Background. Uterine myoma is the most common benign tumor of the pelvic organs in women. One of the effective therapies for myomas is uterine artery embolization (UAE), which can be associated with unintended ovarian embolization. However, there is no certainty about the effect of unintended ovarian embolization on fertility and ovarian function since no precise evidence-based ways of identifying unintended embolization have been described.
Aim. To develop a highly accurate method for identifying unintended ovarian embolization during UAE.
Materials and methods. A series of clinical cases of the utilization of combined embolization material based on the paramagnetic contrast agent gadoteridol and saturable HepaSphere microspheres are presented.
Results. On admission, patients underwent magnetic resonance imaging (MRI) of the pelvic organs with contrast enhancement. After UAE with this combined embolization material, another pelvic MRI without contrast enhancement was performed on the in-hospital day 2. In the first clinical case, no hyperintensive zones were detected in the ovarian stroma. However, in the second case, a previously undetected hyperintensive signal up to 6 mm in diameter was seen in the stroma of the left ovary by repeat MRI.
Conclusion. Using this combined material during UAE significantly increases the accuracy of possible unintended ovarian embolization detection as soon as in the early postoperative period.
Oral Leiomyoma – A Rare Presentation in a Child
Authors: Ali R Patel Mohammad , Shinde Nandkishore , Haneef Mohammed , Arshi Juveria , Joy Sam
Published: February 2023

Leiomyoma is a benign smooth muscle tumour most commonly found in the myometrium of the uterus GI tract skin and lower extremity of the body with abundant smooth muscle. These tumours have been reported to occur at any age and reported in literature as firm slow growing locally circumcised mass which may present as a submucosal nodule. The highest incidence occurs between the 4th to 5th decades of life. Occurrence is unusual and uncommon in paediatric and geriatric age groups. Its occurrence in oral cavity is a rare phenomenon due to the paucity of smooth muscle tissue in the oralperioral region. Most of the cases reported were in adults and very few cases were reported in children. Frequent intra-oral sites of occurrence include tongue lips palatal tissue buccal mucosa and retromolar trigone. The tumours are commonly asymptomatic although some tumours maybe symptomatic and painful. The diagnosis is confirmed by histological studies with the use of specific stains. Surgical excision of the lesion is reported to be the treatment of choice as recurrence is rare and patient responds well to the treatment. This report discusses about a case of rare occurrence of leiyomyoma in a 9-year-old girl who presented with a growth in the oral cavity on the right lower jaw extending to the retromolar region with associated difficulty in speech and chewing for past two months.
PENYUSUNAN RANCANGAN KOMPETENSI TEKNIS DEPARTEMEN HUMAN RESOURCES PADA PT X
Authors: Ryantandi Renata Ivana
Published: February 2023

Kompetensi teknis merupakan faktor pendukung dalam melaksanakan jenis pekerjaan tertentu. Kompetensi biasanya diterapkan dalam pengelolaan sumber daya manusia berbasiskan kompetensi. Pada penelitian ini, dilakukan penelitian pada perusahaan yang bergerak dalam Industri Otomotif, pada perusahaan ditemukan bahwa manajemen Sumber Daya Manusia kurang optimal dalam menjalankan fungsinya. Tujuan penelitian ini adalah merancang kompetensi teknis untuk Departemen Human Resources, didahului dengan mengetahui proses perancangan kompetensi teknis pada Departemen Human Resources dan mengetahui kompetensi teknis apa saja yang harus ada dalam Departemen Human Resources. Jenis penelitian ini adalah kualitatif, dengan metode studi kasus. Teknik pengumpulan datanya adalah wawancara dengan tiga orang dari Departemen Human Resources dan dilengkapi juga dengan data sekunder yang relevan dari perusahaan. Hasil dari penelitian ini adalah perancangan kompetensi teknis untuk Departemen Human Resources yang terdiri dari 30 kompetensi teknis dengan standar level dimulai dari level 0 sampai 3. Rekomendasi yang dapat diberikan adalah Departemen Human Resources sebaiknya dapat mengimplementasikan rancangan ini dan mengembangkannya untuk keseluruhan perusahaan.
Research on the Training of Interdisciplinary-Based Intelligent Manufacturing Talents
Authors: Qin Yuan , Wang Meng , Li Mei
Published: February 2023

As a significant field of research under the 14th Five Year Plan, intelligent manufacturing holds a special position in industrial upgrading and core technology independence. Intelligent manufacturing is an important support for building a “scientific and technological power” in the future. Cultivating creative interdisciplinary talents who can adapt to the development of intelligent manufacturing industry in the new era is of great significance for China to realize the modernization and autonomy of its industrial system. In view of the existing gap between the interdisciplinary talent training of intelligent manufacturing and the actual needs of the industry, this paper focuses on the concept of interdisciplinary construction. Based on the cycle improvement of professional construction, a curriculum system that integrates the interaction of interconnected projects is established. Through four specific measures, namely establishing the collaborative development system of intelligent manufacturing specialty, building a cycle diagnosis and reform system of intelligent manufacturing specialty, improving the curriculum system of integrated modular specialty group, and setting up an application scenario project-based curriculum, we hope to provide reference for the cross-training of compound intelligent manufacturing talents.
Edukasi Pengetahuan Infeksi Jamur Superfisial dan Potensi Penggunaan Tanaman Obat sebagai Terapi Antijamur
Authors: Ratnaningrum Kanti , Rakhmawatie Maya Dian , Marfu’ati Nanik
Published: February 2023

Latar belakang: Infeksi jamur superfisial masih menjadi masalah kesehatan di Indonesia. Indonesia merupakan daerah tropis dengan tingkat kelembaban tinggi. Hal ini merupakan kondisi yang baik untuk pertumbuhan jamur. Sebagian penderita infeksi jamur superfisialis masih memilih menggunakan obat yang dijual bebas tanpa resep dokter. Penggunaan obat tanpa resep dokter meningkatkan potensi resistensi obat. Indonesia memiliki variasi tumbuhan yang dapat digunakan sebagai alternatif pengobatan termasuk sebagai antijamur. Tujuan: Meningkatkan pengetahuan infeksi jamur superfisialis dan potensi tanaman obat yang digunakan sebagai terapi antijamur. Metode: Edukasi berbentuk kegiatan edukasi dengan materi infeksi jamur superfisial dan potensi penggunaan tanaman obat sebagai terapi antijamur. Kegiatan dilakukan di laboratorium Biomedik Fakultas Kedokteran Universitas Muhammadiyah Semarang menggunakan media power point. Evaluasi dilakukan menggunakan analisis kuantitatif hasil pre-test dan post-test. Hasil: Terdapat peningkatan signifikan pengetahuan peserta edukasi dengan rerata 24,6 poin (p=0,005). Kesimpulan: Terdapat peningkatan pengetahuan perihal infeksi jamur superfisial dan potensi penggunaan tanaman obat sebagai terapi antijamur.
Kata Kunci: antijamur, dermatofitosis, infeksi jamur, tanaman obat
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Abstract
Background: Superficial fungal infection is still a health problem in Indonesia. Indonesia is a tropical area with high humidity levels. These are favorable conditions for fungal growth. Some people with superficial fungal infections still choose to use over-the-counter drugs without a doctor's prescription. The use of drugs without a doctor's prescription increases the potential for drug resistance. Indonesia has a variety of plants that can be used as traditional drugs, including antifungals. Objective: Increase knowledge of superficial fungal infections and the potency of medicinal plants used as antifungal therapy. Method: This activity is outreach with material on superficial fungal infections and the potential use of medicinal plants as antifungal therapy. The activity was carried out in the Biomedical Laboratory of the Faculty of Medicine Universitas Muhammadiyah Semarang using PowerPoint media. Result: There is a significant increase in the knowledge of participants, with an average increase of 24.6 points (p-value 0,005). Conclusion: There is an increase in knowledge about superficial fungal infections and the potential use of medicinal plants as antifungal therapy.  
Keywords: antifungal, dermatophytosis, fungal infection, medicinal plant
Penyuluhan Tentang Cegah Stunting Menuju Kelurahan Sehat
Authors: Rahayu Agustin , Surasno Diah Merdekawati , Mansyur Suryani , Andiani  , Musiana
Published: February 2023

Latar belakang: Stunting adalah masalah kurang gizi kronis yang disebabkan oleh kurangnya asupan gizi dalam waktu yang cukup lama, sehingga mengakibatkan gangguan pertumbuhan pada anak yakni tinggi badan anak lebih rendah atau pendek (kerdil) dari standar usianya. Tujuan: Untuk meningkatkan pengetahuan tentang stunting pada ibu hamil dan ibu yang memiliki balita di Kelurahan Rum Balibunga. Metode: dilakukan penyuluhan yang kemudian untuk melihat indikator keberhasilan yang dicapai maka, dalam penyuluhan ini menggunakan pre-test dan post-test. Hasil: Rerata nilai pengetahuan peserta tentang stunting mengalami peningkatan yaitu semula hasil pre-test sebesar 5,20 menjadi sebesar 7,60 saat post-test (p = 0.000).  Nilai pengetahuan ibu tentang stunting yang mengalami peningkatan menunjukan bahwa materi yang diberikan melalui penyuluhan dapat diterima dan dipahami dengan baik. Kesimpulan: kegiatan penyuluhan dapat meningkatkan pengetahuan tentang pencegahan stunting. Direkomendasikan kepada tenaga kesehatan untuk terus memberikan edukasi terkait stunting dan pencegahannya sehingga masyarakat dapat lebih berperan aktif dalam mencegah stunting pada anak.
Kata Kunci: pengetahuan, penyuluhan, stunting
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Abstract
Background: Stunting is a chronic malnutrition problem caused by a lack of nutrition for a long time, thus causing growth retardation in children, namely the child's height is lower or shorter (dwarf) than the standard age. Objective: To increase knowledge about stunting in pregnant women and mothers with toddlers in Rum Balibunga Village Method: counseling with pre-test and post-test to see indicators of success achieved. Result: The average value of participants' knowledge about stunting increased, namely the pre-test result was 5.20 to 7.60 during the post-test (p=0.000). The value of the mother's knowledge about stunting which has increased shows that the material provided through counseling can be well received and understood. Conclusion: extension activities can increase knowledge about stunting prevention. It is recommended that health workers continue to provide education regarding stunting and its prevention so that the community can play a more active role in preventing stunting in children.  
Keywords:  knowledge, counseling, stunting
franquismo en el aula. Una propuesta didáctica alternativa
Authors: Mancha Castro José Carlos
Published: February 2023

El presente artículo analiza cómo se desarrolla el proceso de enseñanza-aprendizaje de la historia del franquismo en las aulas de secundaria y propone un modelo metodológico alternativo, centrado en una didáctica del sentir la historia situada. A través de una metodología investigativa, de carácter constructivista, y centrada en el aprendizaje significativo, se propone abordar la comprensión y el estudio de la dictadura franquista investigando y poniendo en reflexión hechos sociales y simbólicos de carácter local. La finalidad es acercar el objeto de estudio al alumno, hacer que lo sienta como algo propio y que sirva para la comprensión de su mundo. Asimismo, se debate la necesidad de abordar un cambio didáctico en la enseñanza de las Ciencias Sociales, abandonando el modelo tradicional (hegemónico) para avanzar hacia un modelo alternativo que descubra la utilidad de las Ciencias Sociales a través de su método de conocimiento: la investigación (escolar).
valor de la historia. Estudio de alternativas curriculares en Secundaria (2): aprender sobre la alteridad y la naturaleza humana a través de la empatía o toma de perspectiva histórica
Authors: Paricio Royo Javier
Published: February 2023

Partiendo de una revisión del debate académico sobre la empatía o toma de perspectiva histórica, se ofrece una propuesta de currículo de historia para Secundaria centrado en esta dimensión del pensamiento histórico. Este segundo artículo de la serie “El valor de la historia” indaga cómo podría ser un currículo en el que los estudiantes se enfrenten al reto de explicar por qué los seres humanos actuaron como lo hicieron en determinadas circunstancias y en el que exploren lo que creían, pensaban o sentían para hacer lo que hicieron. Se analizan algunas de las claves fundamentales que deberían tenerse en cuenta en el diseño y se argumenta el valor de dar esta orientación curricular a la asignatura partiendo de la importancia de desarrollar el sentido de alteridad y de expandir su comprensión de lo que significa ser humano.
Reseña de Género y Didácticas. Una mirada crítica, una aproximación práctica
Authors: Fernández Valencia Antonia
Published: February 2023

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Jugar como vía de inmersión en contextos históricos: una propuesta de diseño didáctico basada en una narrativa interactiva gamificada
Authors: Gallaguet Bohr Johan Martí
Published: February 2023

A modo de recurso de aprendizaje, el mundo del juego se ofrece como un poderoso aliado en la empresa de la renovación de métodos y estilos de enseñanza de la Historia que la Didáctica de las Ciencias Sociales lleva reclamando ya por un largo tiempo. El presente artículo explora desde una perspectiva teórica las diferentes metodologías didácticas que se sirven del juego y presenta un ejemplo de diseño didáctico gamificado en base a un juego de narrativa interactiva de ambientación histórica. Puesta a prueba la funcionalidad didáctica de la herramienta en una primera ocasión experimental, el análisis de las percepciones del docente durante la actividad y las valoraciones del alumnado recogidas por encuesta complementan los resultados de una prueba de conocimientos y permiten reflexionar sobre el potencial y las limitaciones de recursos de esta índole a la hora de promover un aprendizaje más significativo.
Analytical Study of the International Economic Policies of Iran and Russia: A Move to Bilateral Cooperation under Sanctions
Authors: Rezaeinejad I.
Published: February 2023

The high inflation, unemployment rate, and production reduction are apparent characteristics of the current state of Iran’s economy. Therefore, studying solutions for the relationship with other countries and broader exposure to international trade is crucial. However, in the situation of sanctions, few countries can establish a free economic relationship with Iran, and Russia is one of the most important countries in this context. The article aims to investigate the history and perspectives of the economic cooperation between Iran and Russia. The paper uses an analytical — descriptive method to depict the international economic policies of Iran and Russia and the opportunities and challenges in their bilateral economic cooperation to pass unfair international sanctions and pursue economic development. The author concludes that although the political dimension was dominant in Iran and Russia relations, the two countries have realized the importance of bilateral economic ties, trying to improve the existing connections, which have shown the positive future of cooperation between the two countries.
Association between Financial Knowledge, Financial Attitude and Financial Behaviour among Young Population in India
Authors: Sangeeta . , Panwar A. K. S. , Aggarwal P. K.
Published: February 2023

The research aims to explore the associations between the determinants of financial literacy among the young population of Haryana, India.

   The research methodology included collecting data from 117 respondents through a well-structured questionnaire and investigating the associations using Chi-square criteria. The results of this research show a strong association between the determinants of financial literacy (financial knowledge, financial attitude, and financial behaviour). Among the research limitations are the relatively small sample size and inclusion of only the rural population of Haryana. This research will help researchers, policymakers and governments to focus on financial knowledge, financial attitude and financial behaviour as determinants for strengthening financial literacy.
National Policy of Black Sea Region Countries Towards Sustainable Development
Authors: Stroev P. V. , Dudnik A. I. , Konishchev E. S.
Published: February 2023

The authors consider the integration of the concept of sustainability in the member countries of the Organization of the Black Sea Economic Cooperation (BSEC). The concept of sustainable development is viewed through the prism of economic, social and environmental approaches.

   The subject of the study is the Sustainable Development Goals (SDGs) in the BSEC countries.

   The purpose of the research is to study the integration of the goals and indicators of sustainable development in the national policies of the BSECcountries.

   The relevance lies in the international community’s growing attention to forming a vector for balanced socio-economic development, taking into account current social, demographic and environmental factors.

   The scientific novelty lies in the analysis of the advancement of the concept of sustainable development in the BSEC countries, as well as the level of integration of the SDGs in the national policies of states.

   As part of the study, the authors used the methods of institutional analysis, system analysis, analysis of statistical data and official documents. Based on the results of the analysis, it was revealed that despite the high level of integration of the SDGs within the framework of the BSEC, not all goals and indicators of sustainable development formed by the United Nations (UN) are tracked in countries. The authors concluded that the national characteristics of the economy, the social sphere and the environmental situation push states to adapt individual indicators to national specifics.
Exploring Foreign Teachers’ Perceptions of Communication with Students in Online Learning in China: A Case Study
Authors: Guo Jing , Asmawi Adelina
Published: February 2023

Under the influence of the Covid-19 pandemic, and with the widespread use of online learning, the way in which teachers communicate with students via the internet has attracted great attention. Online communication bears unique challenges, such as the absence of nonverbal cues and lack of social interaction, both of which are necessary to enrich and assist learning in an online setting. This paper aims to explore foreign teachers’ perceptions of online communications for learning and to examine the communication challenges in that environment. Set in China, this study adopts a qualitative design using semi-structured online interviews as data collection instrument. Seven foreign teachers (non-Chinese) (three females and four males) participated in this research. The thematic analysis method was adopted for data analysis. Results showed that four themes were generated, which were effectiveness, emotional feelings, means of communication, and communication skills. In addition, three themes were discussed in terms of communication challenges in online learning, such as technical obstacles, cultural issues, as well as communication problems. Teachers are encouraged to be prepared to deal with these problems. This research brings new and practical thoughts to learners and instructors in order to optimize the effect of online learning and makes recommendations for future projects.
ASSOCIATION AS ONE OF THE PHASES OF COGNITIVE ACTIVITY CONSCIOUSNESS IN THE PROCESS OF GENERATING A NEW IDEA (REPRESENTATION OF ASSOCIATIVE THINKING ON THE EXAMPLE OF LAW)
Authors:   Legal Research Center, Alikperov Khanlar D.
Published: February 2023

The generation of a new idea, developed at the stage of the associative phase of thinking, is carried out through a multi-stage activity of consciousness: the formulation of the problem (hereinafter abbreviated – “P”); insight into the essence of “P” (study, analysis, hypotheses, etc.); isolation from “P” unknown faces; development of an algorithm for finding a way to solve these faces; partial withdrawal from attempts solve “P” by traditional scientific methods; arbitrary transition of “P” with all the accumulated information about it to the subconscious layers of the psyche to search for its solution; search on the subconscious level for the optimal way to solve the “P” and relay the results obtained to consciousness, which has temporarily moved away from its solution; a random figure (form, image, etc.) that suddenly appeared in front of the researcher (at the mental or physical level), not related to the “P” being solved. However, its configuration and individual elements cause associative comparisons with the unresolved “P” and, as it were, prompt the putting forward of new hypotheses about the methods of its solution; maximum activation of the associative impressions that have arisen, their decoding, study, comparison, analysis, identification of connections between them and with “P”; connection of inductive thinking in order to check and streamline the resulting associative versions of the ways to solve “P”; the process of developing a clear verbal formulation of the results of inductive thinking; sudden insight – finding the best way to solve a problem. This far from complete picture of the mechanism of associative generation of correct insight suggests that insight is not at all a generous “gift” of the information field of the Earth or other mysterious forces of nature. Most likely, it is a concentrated fruit of the researcher’s own reflections on the problem, over the solution of which his convolutions “fought” for a long time, which, having reached an emergent state, were transformed into a ready-made solution recipe. The problem under consideration. In other words, the knowledge accumulated by the researcher at a certain stage moves to a qualitatively different level, which, in turn, gives rise to fundamentally new cognitive abilities in him, due to which sometimes (this already depends on the genes) his “Ego” (from the subconscious mind) starts the process enlightenment, the trigger of which is the problem, on the solution of which he is working.
ON THE RELATIONSHIP BETWEEN THE CONCEPTS OF PHENOMENON AND NOUMENON IN MODERN SOCIOLOGY
Authors:   Russian State University for the Humanities, Toshchenko Zhan T.
Published: February 2023

The article analyzes the meanings of the studied processes and phenomena. It is shown that modern sociology is limited mainly to traditional approaches, which are based on the analysis of phenomena – obvious, relatively simply interpreted concepts. It is shown that with all the variety of methodological orientations and methodological techniques, sociological research is mainly aimed at identifying, using and taking into account indicators of the life world, which are expressed through knowledge, opinion, needs, motives, value orientations, interests and other components of public consciousness, as well as such behavioral shares as deeds and actions. A prominent place is occupied by the phenomena of the macro-, meso- and microenvironment. With this approach, these components of the life world appear as phenomena perceived in experience, as objects of sensory contemplation, as a product of empirical knowledge. The conclusion is substantiated that such an approach seriously limits the possibilities of cognition. A transition to the use of the “noumenon” category is required, which makes it possible to reveal the intelligible, latent essence of phenomena and processes, which becomes apparent as a result of study, comprehension and contemplation. In this regard, the essence and content of the noumenon are determined, its ascent from the phenomenon is revealed, as well as its use in the study of social reality – the life world of people, social groups and communities of the modern world.
Pterigium Okuli Dextra et Sinistra
Authors: Rohaya Syarifah , Siregar Wina Yunida M
Published: February 2023

Pterigium adalah salah satu gangguan permukaan mata yang umum terjadi. Pterigium selain menyebabkan gangguan kosmetik juga dapat menyebabkan hilangnya penglihatan apabila mencapai aksis penglihatan. Risiko timbulnya pterigium 44 kali lebih tinggi di daerah tropis seperti Indonesia jika dibandingkan dengan daerah non-tropis. Pasien wanita usia 63 tahun datang ke Poliklinik Mata RSUD Cut Meutia dengan keluhan mata kanan terasa berasap sejak 6 bulan ini. Pasien mengeluhkan penglihatannya kabur, adanya rasa mengganjal terutama pada mata kanan, dan mata berair. Pada pemeriksaan oftalmologi didapatkan visus OD 3/60 dan OS 6/45, pinhole visus tidak maju, serta ditemukan adanya selaput pada konjungtiva bulbi OD yang memanjang hingga kornea dan OS hingga limbus. Pasien didiagnosis dengan Pterigium OD grade IV dan Pterigium OS temporal grade II serta OS nasal grade I dengan Katarak Senilis. Pasien diberi artificial tears dan direncanakan untuk eksisi pterigium. Kacamata dan topi pelindung juga digunakan. Prognosis pasien secara umum adalah dubia ad bonam.
Diabetes Mellitus dengan Ulkus Kaki Diabetik
Authors: Fonna Tischa Rahayu , Siregar Wina Yunida M , Putri Baluqia Iskandar
Published: February 2023

Diabetes Mellitus (DM) merupakan suatu kelompok penyakit metabolik dengan karakteristik hiperglikemia yang terjadi karena kelainan sekresi insulin, kerja insulin atau kedua-duanya. Pasien perempuan (38 tahun) datang dengan keluhan nyeri di jempol kaki kanan sejak 1 minggu ini. Luka awalnya tidak terasa nyeri. Luka saat ini bernanah sehingga menyebabkan nyeri terutama saat berjalan. Pasien mengalami kebas pada kedua kakinya sejak beberapa bulan ini. Pasien juga mengeluhkan matanya terasa kabur dan sulit untuk melihat benda yang jauh. Pemeriksaan fisik didapatkan luka terbuka pada jempol kaki kanan berukuran 1x1x0.2 cm berwarna merah kekuningan dengan bagian kulit sekitarnya terdapat pus. Pasien mengalami penyakit DM sejak 2 tahun ini dan mengontrol kesehatannya ke Puskesmas Syamtalira Bayu. Luka pada kakinya tidak dirawat dengan baik dan pasien tidak mengonsumsi obat secara teratur. Pasien diberikan obat antihiperglikemia oral dan antihipertensi. Pasien diberikan edukasi mengenai Diabetes Mellitus dan cara menjaga pola hidup yang sehat.
Evidencias de metamorfismo retrógrado en el Complejo Metamórfico El Oro
Authors: Paucar-Ayala Stalyn David , Ortiz-Muñoz Deymi Jhoel , Solano-Yépez Stalin Paul , Viteri-Santamaría Francisco Rigoberto
Published: February 2023

El Complejo Metamórfico El Oro, ubicado al suroccidente del Ecuador, está formado por distintas rocas metamórficas de grado bajo y alto. Se estudia la evidencia de retrometamorfismo mediante la revisión bibliográfica, en especial, de los resultados obtenidos en el Complejo Metamórfico El Oro (1990-1993) como parte del Proyecto Cordillera Real (1986-1993) y de otras publicaciones recientes. Se ha mencionado evidencia de retrometamorfismo en la Unidad Quebrada Plata de la facies anfibolita a esquistos verdes y en el complejo ofiolítico Raspas de eclogita a esquistos azules. Además, se ha obtenido datos de petrografía de retrometamorfismo en un bloque de eclogita de La Unidad La Chilca. Se describe al metamorfismo retrogrado respecto a la evolución del complejo metamórfico (Unidad Quebrada Plata), los procesos de exhumación, estructuras geológicas asociadas y reacciones minerales.
Analisis Kesulitan Guru dalam Menyusun Rencana Pelaksanaan Pembelajaran (RPP) Kurikulum 2013 di Sekolah Dasar (SD) Yayasan Hadi Sakti
Authors: Hakim Lukmanul , Safruddin Safruddin , Husniati Husniati
Published: February 2023

Penelitian ini bertujuan untuk mendeskripsikan kesulitan guru dalam penyusunan Rencana Pelaksanaan pembelajaran (RPP) Kurikulum 2013 di Sekolah Dasar (SD) Yayasan Hadi Sakti. Problematika tersebut terdiri atas kendala, faktor penyebab, dan strategi yang digunakan guru dalam mengatasi kendala yang diamali dalam menyusun RPP Kurikulum 2013. Penelitain ini bertujuan untuk mendeskripsikan kesulitan guru dalam Menyusun RPP Kurikulum 2013, mendeskripsikan factor penyebab kesulitan guru dalam penyusunan RPP Kurikulum 2013, serta mendeskripsikan strategi guru dalam menghadapi kesulitan dalam penyusun RPP Kurikulum 2013. Pendekatan yang digunakan dalam penelitian ini yaitu pendekatan kualitatif dengan jenis penelitian deskriptif naratif. Teknik pengumpulan data menggunakan wawancara dan dokumentasi. Analisis data menggunakan teknik analisis data Model Milles dan Huberman yang terdiri atas, reduksi data, penyajian data, dan penarikan kesimpulan. Hasil Penelitian: 1) Kesulitan yang dihadapi oleh guru dalam penyusunan RPP Kurikulum 2013: Guru Kesulitan dalam mengembangkan beberpa komponen RPP Kurikulum 2013, komponen tersebut adalah indikator pencapaian kompetensi, metode pembelajaran, media pembelajaran, langkah-langkah pembelajaran dan penilaian pembelajaran. Kesulitan selanjutnya adalah guru tidak menguasai IT. 2) Faktor penyebab dari kesulitan yang dihadapi oleh guru dalam menyusun RPP adalah: guru tidak pernah mengikuti pelatihan, guru tidak memiliki waktu untuk menyusun RPP, usia guru yang sudah tua. 3) Strategi yang digunakan guru dalam mengatasi kesulitan yang dihadapi: menggunakan RPP yang sudah ada, menggunakan buku guru sebagai salah satu pedoman dalam menyusun RPP Kurikulum 2013, melakukan diskusi dengan guru yang pernah mengikuti pelatihan dan workshop.
Pengaruh Implementasi E-learning Berbasis Quizizz terhadap Hasil Belajar PPKn
Authors: Astika Susi , Herianto Edy , Sawaludin Sawaludin , Sumardi Lalu
Published: February 2023

Penelitian ini dilakukan untuk mengetahui: Apakah terdapat akibat dari implementasi e-learning berbasis quizizz terhadap hasil belajar siswa pada mata pelajaran PPKn di SMAN 1 Sambelia. Pendekatan yang diaplikasikan adalah kuantitatif yang jenisnya quasi eksperimen dengan desain time series desain. Populasinya adalah seluruh siswa kelas XI di SMAN 1 Sambelia yang terdiri dari 4 kelas dan sampel yang diambil 1 kelas yang telah memenuhi kriteria yang telah ditentukan yaitu kelas XI MIPA (I), dengan teknik purposive sampling. Data diolah menggunakan tes. Teknik tes yang digunakan yaitu pre-test dan post-test. Analisis  data menggunakan uji prasarat yaitu uji normalitas (Kolmogorov-Smirnov) dan uji homogenitas (levenâ€™s statistic), dan uji hipotesis yang menggunakan uji-t (one sample t-test). Pelaksanaan pembelajaran dilakukan sebanyak empat (4) kali pertemuan. Terdapat adanya pengaruh  implementasi e-learning berbasis quizizz terhadap hasil belajar siswa pada mata pelajaran PPKn. Dibuktikan dengan diproleh sig. (2-tailed) â‰¤ 0.05 = (0.000 â‰¤ 0.05)