bluuebunny/crossref_metadata_2025 huggingface dataset:
Metformin induced M2 polarization to improve peripheral nerve regeneration by regulating AMPK/PGC-1α/PPAR-γ pathway
Authors: Luo Gaojie , Zhou Zekun , Li Cheng , Zhang Peiyao , Chen Wei , Li Xiaoxiao , Tang Juyu , Qing Liming
Published: March 2023

Peripheral nerve regeneration is a complex process that involves many signaling pathways, and M2 macrophage polarization was recognized to play a pivotal role in this process. The neuroprotective effects of metformin have attracted wide attention, but few reports focusedon the potentialeffects of metforminin immunomodulatory properties to improve the peripheral nerve regeneration by affecting M2 macrophage polarization. In this study, a rat model of sciatic nerve injury and an inflammatory model of bone marrow-derived macrophage (BMDM) cells were established to examine the potential mechanism of metformin treatment in peripheral nerve repair. Our research demonstrated that metformin treatment was able to accelerate functional recovery, axon regeneration and remyelination, and promote M2 macrophage polarization. In vivo, metformin could transform pro-inflammation macrophages into pro-regeneration M2 macrophages. It was also found that the levels of relative proteins of p-AMPK, PGC-1α, and PPAR-γ were significantly increased after metformin treatment. Moreover, the blockage of AMPK abolished the effects of metformin treatment on M2 polarization. Our data indicated that metformin promoted the macrophage polarization towards M2 phenotype by activating the AMPK/PGC-1α/PPAR-γ signaling axis so as to promote peripheral nerve regeneration. These findings may contribute to a more comprehensive understanding on the molecular mechanism of metformin treatment and its potential in peripheral nerve regeneration.
Potential of biological invasion for carbon sequestration in a protected area : the case of the Limbe Botanic Garden (LBG) forest, Cameroon
Authors: I Tchinmegni Felenou , Vartant Djeukam Pougoum Stelle
Published: March 2023

The Limbe Botanical Garden (LBG) is a relict urban forest located in the heart of the city of Limbe. This forest has many ecological, economic, social and tourist functions and is the green lung of the city of Limbé. Unfortunately, this forest has always been threatened by various anthropic pressures and more recently by invasive exotic species. These threats make us fear the progressive disappearance of this massif, which would be a threat to the plant and animal populations, the riparian communities and the ecosystem services such as carbon regulation. The general objective of our study is to assess the validity of the hypothesis of increased carbon sequestration of invasive species compared to native species. For the floristic inventory, twenty 100 m2 (10 m x 10 m) plots were set up in this LBG urban forest. We recorded information such as the number of adult and juvenile individuals and the diameter of trees greater than or equal to 10 cm. The inventory recorded 349 plant species. The most frequent species is Cyathea camerooniana with 92.3% presence. Cedrela odorata has a frequency of occurrence of 76.9% in this urban forest and a frequency of 60% in the LBG. This taxon has a very high above-ground biomass (187.4 tC/ha) and therefore the highest carbon storage capacity (93.7 tC/ha). It is followed by Diospyros crassifolia and Dialium pachyphyllum, both native species. Cedrela odorata has a positive impact on carbon sequestration and therefore contributes to the well-being of the people. However, the conclusion needs to be qualified because invasive species can influence the functioning of forests in the long term.
Regulation of redox profile and genomic stability by physical exercise contributes to neuroprotection in mice with experimental glioblastoma.
Authors: Marqueze Luis Felipe , Costa Amanda , Pedroso Giulia , Vasconcellos Franciane , Pilger Bruna , Kindermann Schellen , Andrade Vanessa , Alves Ana , Nery Tatiana , Aguiar Aderbal , Carvalhal Stephanie , Zazula Matheus , Naliwaiko Katya , Fernandez Luiz , Radak Zsolt , Pinho Ricardo
Published: March 2023

Glioblastoma is a very aggressive and common brain cancer. Previous studies have shown that changes in the brain's redox biology interfere with behavioral patterns and DNA damage. The results of these studies, however, have been inconclusive. To evaluate the effects of a physical training program on behavioral aspects, redox and genomic stability parameters in animals exposed to an experimental model of GBM. Forty-seven male C57BL/6J mice aged sixty days were randomly selected and divided into two groups (GBM and sham/placebo surgery), which were subsequently divided into four groups: untrained sham (Sut, n = 10), untrained GBM (Gut, n = 15), trained sham (Str, n = 10), and trained GBM (Gtr, n = 12). The trained animals performed 3 sessions, followed by a rest day, of moderate aerobic exercise on a treadmill for four consecutive weeks, while the untrained animals were kept in boxes during the experimental period. Behavioral indicators were evaluated with open field and rota rod tests. After the last training session, the animals were euthanized and brain, liver, bone marrow, and blood were collected for analysis of redox and genomic instability markers. The results showed higher latency values were sustained by the exercise in Gtr. The elevated levels of total reactive oxygen species in the parietal tissue of Gut animals were reversed after physical training. The Gtr group had a lower tail intensity. Physical exercise is a promise as an adjunctive therapy for the management of GBM by modulating redox parameters in the parietal tissue and reduces the genomic instability in liver and blood.
Heavy Metal Levels and Mineral Nutrient Status of Goji Berry (Lycium barbarum L.) from Nigde, Turkey
Authors: ESKİN Bülent
Published: March 2023

Lycium barbarum L. species have economic importance due to their medicinal properties and use as food. Therefore, this research aims to investigate some heavy metal and mineral nutrients (Al, Ba, Co, Cr, Cu, Fe, Mn, Ni, Pb, and Zn) status of this species. Heavy metals and mineral nutrients were analyzed in the plant and soil by using ICP-MS. In addition, the obtained results were evaluated with statistical methods. The determined values of the elementals (in mg/kg) were within ranges of 49.05-508.16 for Al, 1.8-82.58 for Ba, 0.62–2.56 for Cr, 0.11–1.05 for Co, 6.57–32.91 for Cu, 43.49-334.69 for Fe, 9.05-170.35 for Mn, 1.24–7.76 for Ni, 0.16–3.66 for Pb, and 15.89–62.27 for Zn in the plant parts. Correlation results were evaluated for the element contents in fruit-leaf-stem and soil samples. It is concluded that B, Al, Cr, Fe, Ni, Pb, and Zn in the soil positively correlated with Zn, Cr, and Fe found in the fruit and Ni, Zn, and Mn found in stem. Additionally, there is a significant negative relationship between Co and Cu in the soil and Co, Pb, and Ba elements in the leaves. The results of this study may contribute to future research to reach a better understanding on the element uptake and heavy metal accumulation status of species with nutritional and economic value. Moreover, statistical studies that consider the ecological and habitat characteristics of the plant will provide more detailed information about the life cycle of the plant.
Financial Exploitation in Canada: A Predictive Model using ML and AI
Authors: Wasdani Kishinchand Poornima , Lokanan Mark
Published: March 2023

The story of financial victimization and abuse of the elderly, women, and migrants is not new to Canada. However, its implications were given serious legal and social consideration only a decade back when reports on financial exploitation were published by Vancity Credit Union as “The Invisible Crime” in 2014 and as “Suffering in Silence” in 2017. These research studies pointed out that only 3% of the elderly population in Canada were aware of their financial abuse but there were at least 36% of the population that were not aware of being defrauded. National Survey on the Mistreatment of Older Canadians by the University of Toronto in 2015 estimated that by 2030, this crime would target at least 70% of the elderly and vulnerable population of Canada. Hence was the need for a model that could predict financial fraud, prevent victimization, and was practice friendly.
The review of literature pointed to a mix of personal, interpersonal, and institutional factors that increased the attractiveness of victims and the capacity of offenders. The present study uses machine learning and neural networks to develop a logistic regression model that could predict financial exploitation in Canada. Using the data from the Investment Industry Regulatory Organization of Canada, a predictive model based on the three highest predictors of financial exploitation in Canada-age, income, and total net worth was developed. It is difficult to imagine regulators in Canada not using the findings from this study to inform policies regarding financial regulation and victims' protection.
This study is also among the few studies that make a deep dive into the Canadian context and people making the prediction model available to policyholders and financial institutions for thwarting the attempts of defrauding the vulnerable sections of society in Canada notwithstanding the extension of the model to other economies.
Aquaculture 4.0: Hybrid Neural Network Multivariate Water Quality Parameters Forecasting Model
Authors: Eze Elias , Kirby Sam , Attridge John , Ajmal Tahmina
Published: March 2023

This study examined the efficiency of hybrid deep neural network and multivariate water quality forecasting model in aquaculture ecosystem. Accurate forecasting of critical water quality parameters can allow for timely identification of possible problem areas and enable decision-makers to take pre-emptive remedial actions that can significantly improve water quality management in aquaculture industry. A novel hybrid deep learning neural network multivariate water quality parameters forecasting model is developed with the aid of ensemble empirical mode decomposition (EEMD) method, deep learning long-short term memory (LSTM) neural network (NN), and multivariate linear regression (MLR) method. The presented water quality forecasting model is developed using multivariate time-series water quality sensor data collected from Loch Duart company, a Salmon offshore aquaculture farm based around Scourie, northwest Scotland. The performance of the novel hybrid water quality forecasting model is validated by comparing the forecast result with measured water quality parameters data and the real Phytoplankton data count from the aquaculture farm. The forecast accuracy of the results suggests that the novel hybrid water quality forecasting model can be used as a valuable support tool for water quality management in aquaculture industries.
Structure of the assemblage of fruit-feeding butterflies in a high Andean anthropogenic landscape
Authors: Álvarez Carlos Federico , Freitas André Victor Lucci , Iserhard Cristiano Agra , Giraldo Carlos Eduardo , Uribe Sandra Inés , Marín Mario Alejandro
Published: March 2023

The high Andean mountains are ecosystems subject to high human pressure activities, resulting in disturbed areas increasingly dominating the landscapes. However, there needs to have more knowledge about the contributions of different vegetation coverages and species to global diversity at the local level. For three consecutive years, we studied a guild of fruit-feeding butterflies in four different land covers (cloud forests, paramo, mixed anthropogenic habitats, and cattle pastures) in the northern Andes in Colombia, analyzing the diversity and structure of the butterfly assemblage in the region. The assembly showed significant differences between land covers. The mixed anthropogenic habitat was the richest in order q1 and q2 of diversity, and the cloud forest contained the higher abundance and species richness. Abundance shifted from forest to pasture, significantly reducing diversity in cattle pastures, with cloud forest and paramo containing the key endemic species. These results indicate the value of landscape diversity in providing resources and conditions required for the diversity conservation of high Andean butterflies.
Effects of Emotional and Cognitive Changes on Aesthetic Evaluation of Poetry Based on Subjective and Physiological Continuous Responses with Pupil Diameter Measurement
Authors: Hitsuwari Jimpei , Nomura Michio
Published: March 2023

Haiku poetry, a short poem with a clear form, has the potential to elucidate many unknown aspects of linguistic art. Previous studies on haiku appreciation have shown that negative emotion and cognitive ambiguity reduce aesthetic evaluation. Considering the importance of negative emotions and ambiguity in art, it is beneficial to clarify the process of emotional and cognitive changes during aesthetic evaluation. This study examined the temporal effects of emotional and cognitive changes on aesthetic evaluation from multiple perspectives by measuring the ratings of each section of haiku, continuous emotional reports, and physiological changes in pupil diameter. The 112 students first rated the haiku at three time points on items such as beauty, valence, and ambiguity. Next, they rated the same haiku continuously for 20 seconds using a joystick for valence and arousal during which the pupil diameter was measured. The results showed that a decrease in negative emotions and ambiguity explained the beauty of the haiku. In the continuous emotion reports, positive emotions gradually increased for positive haiku and negative emotions gradually increased for negative haiku, while arousal decreased once and then gradually increased for both forms of haiku. Additionally, an increase in pupil diameter also explained the beauty. The roles of negative emotions and ambiguity were revealed by focusing on both subjective and physiological indicators of emotional and cognitive changes during haiku appreciation. This study has contributed to the advancement of our understanding of linguistic art forms by empirically exploring conscious and unconscious emotional and cognitive responses to haiku.
Impact elements of feed grinder: a review
Authors: Iskakov Ruslan , Issenov Sultanbek , Kubentaeva Gulmira
Published: March 2023

The article deals with the issue concerning the working bodies of technological equipment designed for grinding pieces and particles of feed raw materials. The most profiTable feed raw materials are by-products and waste materials of animal origin, which have a valuable high-protein content. An alternative way of mandatory waste disposal is their processing, including mechanical grinding to obtain feed products. In the process of grinding, particular importance is given to the working bodies, with the help of which the raw material is directly divided into parts. In this case, the destruction of the feed material often occurs by means of impact. Impact phenomena have proven to be highly effective in the process of intense cracking and chipping, which leads to the desired separation of the crushed particles into smaller ones. However, it is found that crushers have insufficient efficiency of impact elements. The work analyzes the processes of impact grinding from the standpoint of a number of scientific hypotheses, theories, modeling, simulation, experience and approbation, presented in various scientific publications. When studying and improving the theory of impact, attention is paid to nonlinear problems, cracking, modernization of the theory of brittle fracture, diagrams of force changes during impact force, impact equations, wave theory of impact, peridynamic theory. It should be noted that the main scientific results are directly reflected in the improvement of the design features of hammers. It has been revealed that the main improvement in the design of impact elements is in the direction of increasing the efficiency of working surfaces and developing the combination of impact with cutting, abrasion and crushing
Neoescolástica y su influencia en el catolicismo colombiano del siglo XX
Authors: Ramírez Trillos Osmir , Plata Quezada William Elvis
Published: March 2023

Este artículo se enfoca en resolver un problema poco abordado por la historiografía del hecho religioso en Colombia: ¿cómo se ha enseñado y estudiado la teología en el país en la primera mitad del siglo XX? Para responder esta pregunta se procede a (1) exponer y comprender la teología que se enseñaba en el siglo XX en Colombia, (2) abordar la Pontificia Universidad Javeriana como ejemplo de relación entre esta teología y la sociedad colombiana y (3) analizar la enseñanza impartida en la Facultad de Teología de dicha institución. Al tomar como caso de estudio esta facultad se logra entender el vínculo que se da entre la manera en la que se instruye el clero y la forma en la que la Iglesia actúa ante la sociedad. De ahí se intuye que si la teología enseñada fue de corte tradicional e integrista, del mismo modo será el actuar de la Iglesia, paradójicamente, en una época de fuertes cambios teológicos.
Theoretical Study of 2,6-Dichloro-3-methyl-1,4-benzoquinone Interacting with Graphene
Authors: Sobrinho Leandro , Guerini Silvete
Published: March 2023

Humans, animals and wildlife can suffer consequences due to exposure to toxic substances present in the environment, such as disinfection by-products, the halo benzoquinones, which are formed through reactions between chlorine and natural organic matter present in the water. In this paper, the interaction of 2,6-dichloro-3-methyl-1,4-benzoquinone with graphene layer was investigated by ab initio methods based on the density functional theory. The results show that 2,6-dichloro-3-methyl-1,4-benzoquinone adsorption changes the electronic properties of the nanostructure depending on molecule adsorption site. The calculated binding energies show that this molecule interacts with graphene through a chemical adsorption process when the 2,6-dichloro3-methyl-1,4-benzoquinone molecule is parallel to the graphene layer. Our results are promising because they indicate the ability of graphene to serve as a filter for toxic substances present in the water.
El DIÁLOGO ECUMÉNICO COMO EJERCICIO DE LA FRATERNIDAD CRISTIANA. BASES PARA UNA PASTORAL ECUMÉNICA
Authors: Merino Patricio
Published: March 2023

La región del Biobío presenta una pluralidad de denominaciones cristianas. Este hecho es un desafío para la pastoral y requiere de su acompañamiento. Este artículo, luego de describir la diversidad cristiana de la región, ofrece tres tesis a modo de criterios para la pastoral ecuménica: 1. El diálogo ecuménico es un signo de los tiempos para los cristianos del Biobío. 2. La búsqueda de la unidad de los cristianos se fundamenta en la filiación divina y la fraternidad cristiana. 3. El ecumenismo puede ser entendido como el ejercicio de la fraternidad cristiana.
Anti-Stokes photoluminescence of perovskite CsPbBr-=SUB=-3-=/SUB=- nanocrystals in a fluorophosphate glass matrix
Authors: Kuznetsova M. S.  , Bataev M. N.  , Chukeev M. A.  , Rostovtsev N.D.  , Verbin S. Yu.  , Ignatiev I. V.  , Davydov V. Yu.  , Smirnov A. N.  , Eliseyev I. A.  , Kolobkova E. V.
Published: March 2023

The anti-Stokes photoluminescence (PL) of perovskite CsPbBr3 nanocrystals in a fluorophosphate glass matrix has been found and experimentally studied upon optical excitation to the low-energy edge of the photoluminescence band. The intensity of anti-Stokes PL depends linearly on the pumping power and increases rapidly with increasing temperature. A simple three-level model is proposed that describes well the main regularities of the observed phenomenon. Keywords: perovskites, nanocrystals, anti-Stokes photoluminescence, CsPbBr3, fluorophosphate glass.
Factors Influencing the Clinical Adoption of Quantitative Gait Analysis Technologies for Adult Patient Populations With a Focus on Clinical Efficacy and Clinician Perspectives: Protocol for a Scoping Review
Authors: Sharma Yashoda , Cheung Lovisa , Patterson Kara K , Iaboni Andrea
Published: March 2023

Background

Quantitative gait analysis can support clinical decision-making. These analyses can be performed using wearable sensors, nonwearable sensors, or a combination of both. However, to date, they have not been widely adopted in clinical practice. Technology adoption literature has highlighted the clinical efficacy of technology and the users’ perspective on the technology (eg, ease of use and usefulness) as some factors that influence their widespread adoption.

Objective

To assist with the clinical adoption of quantitative gait technologies, this scoping review will synthesize the literature on their clinical efficacy and clinician perspectives on their use in the clinical care of adult patient populations.

Methods

This scoping review protocol follows the Joanna Briggs Institute methodology for scoping reviews. The review will include both peer-reviewed and gray literature (ie, conference abstracts) regarding the clinical efficacy of quantitative gait technologies and clinician perspectives on their use in the clinical care of adult patient populations. A comprehensive search strategy was created in MEDLINE (Ovid), which was then translated to 4 other databases: CENTRAL (Ovid), Embase (Ovid), CINAHL (EBSCO), and SPORTDiscus (EBSCO). The title and abstract screening, full-text review, and data extraction of relevant articles will be performed independently by 2 reviewers, with a third reviewer involved to support the resolution of conflicts. Data will be analyzed using content analysis and summarized in tabular and diagram formats.

Results

A search of relevant articles will be conducted in all 5 databases, and through hand-searching in Google Scholar and PEDro, including articles published up until December 2022. The research team plans to submit the final scoping review for publication in a peer-reviewed journal in 2023.

Conclusions

The findings of this review will be presented at clinical science conferences and published in a peer-reviewed journal. This review will inform future studies designed to develop, evaluate, or implement quantitative gait analysis technologies in clinical practice.

International Registered Report Identifier (IRRID)

DERR1-10.2196/39767
How Natural Language Processing Can Aid With Pulmonary Oncology Tumor Node Metastasis Staging From Free-Text Radiology Reports: Algorithm Development and Validation (Preprint)
Authors: Puts Sander , Nobel Martijn , Zegers Catharina , Bermejo Iñigo , Robben Simon , Dekker Andre
Published: March 2023

BACKGROUND

Natural language processing (NLP) is thought to be a promising solution to extract and store concepts from free text in a structured manner for data mining purposes. This is also true for radiology reports, which still consist mostly of free text. Accurate and complete reports are very important for clinical decision support, for instance, in oncological staging. As such, NLP can be a tool to structure the content of the radiology report, thereby increasing the report’s value.

OBJECTIVE

This study describes the implementation and validation of an N-stage classifier for pulmonary oncology. It is based on free-text radiological chest computed tomography reports according to the tumor, node, and metastasis (TNM) classification, which has been added to the already existing T-stage classifier to create a combined TN-stage classifier.

METHODS

SpaCy, PyContextNLP, and regular expressions were used for proper information extraction, after additional rules were set to accurately extract N-stage.

RESULTS

The overall TN-stage classifier accuracy scores were 0.84 and 0.85, respectively, for the training (N=95) and validation (N=97) sets. This is comparable to the outcomes of the T-stage classifier (0.87-0.92).

CONCLUSIONS

This study shows that NLP has potential in classifying pulmonary oncology from free-text radiological reports according to the TNM classification system as both the T- and N-stages can be extracted with high accuracy.
Effectiveness of Internet-Based physical examination model for focus populations in the community: A community demonstration trial (Preprint)
Authors: Huang Zhijie , Mai Zhihua , He Yuming , Su Ying , Chen Baoxin , Zheng Chanjiao , Huang Sifan , Zhou Zhiheng
Published: March 2023

BACKGROUND

There is strong evidence that the use of Internet-based interventions can promote the efficiency of physical examination. So far, few studies have investigated the effectiveness of Internet-Based physical examination model for focus populations in the community.

OBJECTIVE

The study aimed at assessing the feasibility and effectiveness of an Internet-Based physical examination model for focus populations in the community.

METHODS

This was a health economic evaluation alongside a community demonstration trial,with 12 months follow-up. Participants were over 65 years old and those with chronic diseases 35 years old and above. The Internet-Based model was tested in the Dashi Street Community, Panyu District, Guangzhou, China in 2021. A total of 5,864 persons were included in the traditional model, and 8,097 in the Internet-Based model. We introduced a cost-benefit analysis(cost-benefit ratio,net benefit) to examine the effects on patients and healthcare staff compared between the 2 models.

RESULTS

The Internet-Based model, comparing to the Traditional model, was associated with higher clinic rate (37.83% vs. 25.12%, odds ratio [OR] = 1.81), higher rates of newly established health records for the elderly (17% vs. 8%, OR = 2.25), higher rates of newly established records for persons with hypertension (7% vs. 2%, OR = 4.00), and higher rates of newly established records for persons with diabetes (3% vs.1%, OR = 3.54) (all, P < 0.05). The annual total labor cost decreased by 22.09%, but the annual medical costs of resident physical examinations increased by 57%. The total benefit of new health documentation was increased by 114%. The satisfaction with physical examinations and the willingness to seek medical treatment at community health service centers were both increased compared to the traditional model (both, P < 0.05). The time waiting for physical examinations of patients of different ages was shorter (P<0.001), and the benefit-to-cost ratio and net benefit were higher (2.45 vs. 1.26;833,100 vs. 190,700).

CONCLUSIONS

Internet-Based physical examination model for focus populations in the community were better than those of the traditional model. It’s worthy of further application and promotion to improve the health management effect of community focus populations.
ChatGPT and beyond: Considerations in the use of Large Language Models (LLMs) in clinical practice (Preprint)
Authors: Seth Puneet , Pomedli Stephen , de Wit Melanie , Mamdani Muhammad
Published: March 2023

UNSTRUCTURED

Artificial intelligence-based chatbots that fall in the category of Large Language Models, such as ChatGPT, have caught the world's attention. They boast a broad range of general capabilities and are believed to have the potential to revolutionize nearly every aspect of work and human interaction. The application of these tools to address administrative and resource challenges in healthcare delivery is promising. This paper discusses the use of these tools to introduce efficiency for frontline healthcare delivery and examines considerations and limitations that must be taken into account when using them in healthcare. Additionally, it explores potential future applications of LLMs in healthcare.
Design of Smart Agricultural Monitoring and Management System
Authors: Bin Zhang , Xiaodan Lin , Renlei Jiao
Published: March 2023

One of the important contents of China’s agricultural construction is vegetable planting, and most of the vegetable planting technology is relatively backward. The commonly used greenhouse planting technology is simply using special mechanical planting management methods, which cannot realize real-time monitoring of crop growth. In order to optimize the crop growth environment and improve the yield, a smart agricultural monitoring and management system based on PLC and MCGS configuration technology is designed. The system combines PLC technology, configuration technology and sensor technology to complete the overall structure design of the control system, and separately explains the hardware design, software design and operation and debugging of the system. The experimental results show that the system can remotely monitor and control the growing environment of crops, such as soil moisture, gas temperature and humidity, light intensity and other parameters, and the operation and maintenance are convenient, which provides a reference method for the intelligent development of agriculture.
The Formation Mechanism of House Price Differences in China’s Urban Area in the Same City—Based on Lasso Bayesian Model Averaging Method
Authors: Pan Jiayao , Ding Shaoling
Published: March 2023

With the development of economy and the expansion of urban scale, the variation of housing prices within Chinese cities has gradually become significant. Based on the housing prices of 79 districts in Chengdu, this paper analyzes the reasons for such differences. With an index system of the price difference of locational housing, a semi-log linear regression Lasso Bayesian average model is constructed, which can realize variable selection while estimating coefficients. Empirical evidence shows that the inequality of social-economic resources and the imbalance of housing supply and demand in the area are important internal factors that lead to the difference in housing prices between areas within the city; the related housing prices have an extremely significant positive impact, showing that the mobility of the place of purchase and the contagion of the house price are the main reasons for housing price; in addition, influential factors have strong positive interaction effects.
Development Communication as Strategic Anti-Albatross to Nigeria’s Insecurity
Authors: Christian Afulike Don , Paschal Ihechu Innocent , Emmanuel Ndukwe Udochukwu , Onyedikachi Madueke
Published: March 2023

This study undertook a critical survey, discussion and analysis of development communication as a strategy to curb Nigeria’s security questions. This is because a state must assure her citizens, non citizens and investors of internal security; various stakeholders must themselves act collectively, thereby employing emerging communication trends and paradigm on participatory dialogical communications. This paper employed desk research method to source data for the study. The study revealed that without a consistent social process of communication for development which must be based on dialogue, using participatory and ownership approaches by communities and individual affected by insecurity, unemployment, poverty and other developmental issues; the evidence to demonstrate the value of efforts by the respective governments and institutions will not be seen. The study, in view of security challenges facing the nation, recommended that all stakeholders should adopt policies and legislation at all levels that will provide enabling environment for communication for development to encourage media freedom and individual rights to information and communication towards a secured society. More also, strengthening networks and partnership at all levels to advance communication for development which will in turn advance security outcomes.
A Review: Aeronautical Components and Systems Should have their Weight Reduced throughout the Design Process
Authors: Kumar Raj , Bairwa Kedar Narayan
Published: March 2023

Lightweight requires cutting-edge materials and imaginative engineering to achieve the same or better technical performance with less material. This approach has been widely used in automobiles, fashion, and packaging, and the aviation sector may benefit from it. Traditional lightweight methods have used high-performance materials like composites, structural optimization using computationally-aided engineering, and cutting-edge manufacturing processes including additive manufacturing, foam metals, and hot forming. This article will examine the most prevalent lightweight technologies and their possible usage in aviation, such as power plants and airframe components. Solar-powered aircraft wings require improvement and are open to lightweight technology. High aspect ratios cause non-linear distortion, aileron reversal, flutter, and rigid-elastic coupling. Lightweight aircraft, UAVs, and rocket subsystems are all being considered. Cutting-edge optimization methods may optimize structural elements and geometrical parameters for optimum structural stiffness, least mass, and energy storage. Additive manufacturing may create composite or multi-material components that can serve several purposes.
Assessment of the Risk of Cardiovascular Diseases and its Relationship with Heart Rate Variability in Physically Active and Sedentary Individuals
Authors: Sousa Monize de Melo e , Xavier Lourdes Carolina Figueiredo , Pereira Raphael do Nascimento , Miranda Cláudia Jeane Claudino de Pontes
Published: March 2023

Heart rate variability (HRV) is the ability of the heart muscle to adapt to changes imposed on the heart. Therefore, a low baseline HRV may indicate a dysfunction of the autonomic nervous system and lead to the development of cardiovascular diseases (CVD). Thus, the objective of the study was to evaluate and compare HRV with the risk of developing CVD in sedentary and physically active individuals. This is an exploratory, experimental, applied study, with cross-sectional design, under ethical opinion number: 5,581,838. In the sample, 24 individuals of both genders, between 30 and 55 years old, were divided into a sedentary group and another physically active group, excluding those who were not within the inclusion criteria and who had clinically diagnosed cardiovascular or cardiopulmonary diseases. . For data collection, the International Physical Activity Questionnaire and the Cardiovascular Risk Stratification Questionnaire were applied; HRV was verified through the Polar H10 cardiac sensor, blood pressure, weight, height and abdomen-hip circumference. The sedentary group had a higher cardiovascular risk when assessing BMI, waist circumference and waist-hip ratio. Furthermore, the results showed, in sedentary individuals, a significantly higher value of systolic and diastolic blood pressure (124.66±8.91 versus 114.50±9.58 - 84.75±7.02 versus 75.66±6, 38, respectively) and heart rate (74.25±7.96 versus 67.41±7.67) when compared to physically active individuals, which associated with HRV data (42.91±7.54 versus 54.75 ±6.82), time domain and frequency domain, suggest greater sympathetic activity to the detriment of parasympathetic activity in sedentary individuals, reinforcing the cardiac autonomic imbalance in this group.
Interferón-gamma: vías de señalización y sus implicaciones en el cáncer
Authors: Zamora-Salas Sayra Ximena , Robles-Villarruel María Lucero , Macías-Silva Marina , Álvarez-Sánchez María E. , Tecalco-Cruz Ángeles C.
Published: March 2023

Los interferones son una familia de proteínas involucradas en actividades antivirales, inmunomoduladoras y antiinflamatorias. En los últimos años, su estudio se ha incrementado en el contexto del cáncer, y uno de los hallazgos más importantes es que son parte del microambiente de los tumores. El interferón-gamma (IFN-γ) es uno de los miembros de la familia de los interferones y tiene funciones protumorales o antitumorales dependiendo del tipo de cáncer y del microambiente tumoral. En esta revisión se discuten los elementos de la vía de transducción de señales canónica del IFN-γ y sus implicaciones en el desarrollo de las neoplasias malignas. Los estudios sugieren que los elementos de la vía activada por el IFN-γ podrían ser útiles como biomarcadores y/o como blanco de terapias para el cáncer.
Relaciones laborales y la pandemia Covid-19: reflexiones sobre las políticas laborales en Brasil
Authors: Cañedo Villareal Roberto , Nagao Menezes Daniel Francisco
Published: March 2023

En este artículo investigamos qué escenario laboral enfrenta Brasil con la pandemia Covid-19, con el fin de evaluar en qué medida las estrategias de salud colectiva, como el aislamiento social, pueden ser viables para las personas que viven del trabajo y qué nivel de apoyo puede brindarles nuestra cobertura de protección social pública. Para ello, se debatirá la racionalidad que ha organizado las relaciones laborales en el país, así como su dominio por parte del Estado, a través de referencias teóricas que problematizan el advenimiento del neoliberalismo y las tensiones engendradas por la legislación laboral. Se discute el aislamiento social como estrategia de salud colectiva, evaluando quiénes son los sujetos capaces de adherirse a esta estrategia, quiénes se sacrifican para que funcione (y en qué términos se hace este sacrificio) y, aún así, quiénes son los sujetos que caen en este escenario a través de un lenguaje asistencial y no de derechos. Estas reflexiones nos permiten lograr importantes orientaciones de la política social para enfrentar la pandemia, problematizando las debilidades de nuestro modelo de regulación social del trabajo, más allá del contexto de crisis.
El trabajo a distancia como mecanismo “estrella” en época de pandemia: posibles riesgos laborales derivados de su mala implantación
Authors: Martín Rodríguez María Olaya
Published: March 2023

Este artículo comienza por analizar las implicaciones del coronavirus sobre el mercado de trabajo en Europa y especialmente en España, para luego profundizar en el trabajo a distancia como medida organizativa en tiempos de pandemia global. De dicho análisis se destacarán aquellos colectivos o grupos de trabajadores más vulnerables a la pérdida de empleo. Si bien, como no podía ser de otra forma en un estudio jurídico, se hará una breve referencia a las primeras normas que comenzaron a regular esta modalidad de trabajo tanto a nivel internacional como interno. Finalmente, se tratarán los nuevos riesgos psicosociales derivados del uso extensivo de las TIC’s y las medidas preventivas que se pueden llevar a cabo.
¿Es necesaria la regla del precedente?
Authors: Pulido Ortiz Fabio Enrique
Published: March 2023

Este trabajo se ocupa de la pregunta por el carácter contingente o necesario de la regla de precedente en los ordenamientos jurídicos. Se argumenta que la regla de precedente en sentido amplio (aquella que configura el funcionamiento de los precedentes judiciales) es una norma necesaria de los sistemas jurídicos. En el trabajo se identifican tres formas (exhaustivas y excluyentes) que puede adoptar la regla de precedente: a) una regla de precedente vinculante, b) una regla de precedente como admisión, y c) una regla de precedente como rechazo. Se concluye que la forma que adopte la regla de precedente es contingente en cada ordenamiento jurídico. No obstante, bien sea por las razones conceptuales asociadas a la noción de normas de competencia o por la centralidad del principio de legalidad, lo cierto es que en aquellos ordenamientos jurídicos que no contemplen las condiciones para crear, modificar y aplicar precedentes judiciales se debe entender que existe implícitamente una regla de precedente como rechazo.
Crítica al fideísmo de los derechos humanos de Norberto Bobbio
Authors: Isler Soto Carlos
Published: March 2023

Es conocida la tesis de Norberto Bobbio de que no es necesario buscar un fundamento absoluto de los derechos humanos, sino que lo necesario es protegerlos. En el presente artículo exponemos la tesis de Bobbio, mostramos su similitud y diferencias con posiciones de autores como Maritain y Villey, y la sometemos a crítica. Concluimos que Bobbio comete varias falacias en su argumentación, como la falacia genética, la naturalista, y, además, sus mismas ideas sobre el modo de proteger los derechos humanos resultan discutibles.
El derecho y el origen de la palabra. La filosofía jurídico-analítica de Rolando Tamayo y Salmorán
Authors: Mattei-Gentili Piero
Published: March 2023

Este trabajo ha sido concebido como un homenaje para Rolando Tamayo y Salmorán por medio del examen de algunas de sus principales aportaciones a la filosofía del derecho. Con esto en mente, el texto parte de un planteamiento panorámico sobre el estado de la filosofía jurídica en México y el ambiente en el que se desarrolla Tamayo. Con posterioridad, se explica que el ensayo estará enfocado en explorar dos aspectos de su obra. Primero, la importancia de conocer el origen de la ciencia del derecho, la jurisprudentia, de la formación de sus conceptos, sus fundamentos romanos y los postulados epistémicos que tomaron de los griegos. Segundo, la definición del derecho como una técnica de reforzamiento de la conducta que es posible encontrar en todas las sociedades. De modo tangencial se explica el concepto de norma como herramienta primordial de la técnica jurídica.
Precedent and Civil Law: The Road Ahead. Reflections on Precedent Based on the Works of Flavia Carbonell and Rodrigo Camarena
Authors: Gascón Abellán Marina
Published: March 2023

This paper is the result of the analysis and discussion that took place at the Problema. Anuario de filosofía y teoría del derecho seminar entitled “The Construction of Precedent in Civil Law: Debates, Concepts and Challenges.” At this event, Flavia Carbonell and Rodrigo Camarena delivered a concise presentation on precedent in their respective countries (Chile and Mexico), addressing issues of a regulatory, practical, theoretical and conceptual nature. Having witnessed both their arguments with keen interest and inspired by their presentations, I offer my points of view on the most important and prominent aspects of their contributions.
Legal Arguments and Case Law Precedents: An Experiment in Judicial-Sociological Experiment Between Practice and Theory
Authors: Zorzetto Silvia
Published: March 2023

The object of this paper is to analyze some main types of judicial arguments based on precedents to grasp their relevance and range in practice. The analysis is drawn from the case law of the Italian Court of Cassation Civil United Sections, to elicit a comparison between the uses of precedents in different legal systems. However, the analysis is of an explanatory or critical-reconstructive nature and illustrates a series of uses and problems linked to judicial reasoning, the scope of which is general and therefore goes beyond the specific juridical context at hand. The analysis is conducted from an internal point of view and, particularly from the standpoint of the decision-maker (i.e., the judge) and addresses some vexatae quaestiones surrounding the idea that case law is the source of law in practice. This study the opinion that the argument surrounding precedent is, in fact, a very heterogeneous and much more extensive family of arguments than what is usually assumed from traditional taxonomies of judicial arguments. Moreover, the study defends the opinion that case law is inevitably a 'source of law' for pragmatic reasons inherent to judicial reasoning.
Are Rules Governing the Use of Precedent Necessary?
Authors: Pulido Ortiz Fabio
Published: March 2023

This paper addresses the issue of the necessary or contingent nature of the rules governing the use of precedent. The author argues that the rules governing the use of precedent in lato sensu (the rules that define the legal operation of judicial precedent) is a necessary rule of legal systems. However, legal systems have three different (exclusive and exhaustive) kinds of rules governing the use of precedent: a) binding rules governing the use of precedent, b) rules admitting the use of precedent and c) rules rejecting the use of precedent. The main conclusion is that whether for conceptual reasons of conferring power or for the centrality of the rule of law in current legal systems, when a legal system does not define the legal operation of judicial precedents, it can be said say there are (implicit) rules rejecting the use of precedent.
A Review on Recognizing of Positive or Negative Emotion Based on Speech
Authors: Kumar Dr. P Kiran , Rani K Sudha , Sai K Praveen , Krishna N Ramesh , Aditya S Chaitanya Naga
Published: March 2023

Abstract: Emotions are the feelings of a person and the reaction to a situation. People can verbally or nonverbally convey their feelings. In the literature ofSpeech emotion recognition, many of the techniques have used traditional ways to detect emotions, this paper present different way of recognizing emotions, by speech signals are processed by CNN to extract features, the extracted features are then used to input SVM. The SVM outputs the predicted emotions. From this approach we improved accuracy by testing and training the models based on the input audio data
Growth and Investigation Studies of Pure and Glycine Doped Zinc Tris-thiourea Sulphate (ZTS) Single Crystals
Authors: Nimalan T. , Vimal J. , Kumar E. Praveen , Jana N. , Shanmugasundram K. , Govindan E. , Manigandan M.
Published: March 2023

Abstract: Zinc Tris-thiourea Sulphate (ZTS) belongs to the family of semiorganics nonlinear optical materials. Good quality single crystal of pure and doped ZTS have been grown by slow evaporation solution growth technique at room temperature. The grown crystals have been subjected to FTIR and UV visible spectra studies. The Fourier Transform Infrared analysis confirms the presence of functional groups and zinc coordination in grown crystals. The UV visible spectrum revels that grown crystals were transparent in the entire visible region. These investigations indicated that impurity played an important role in the changes of the transmittance of ZTS crystals.
Integral Solutions of the Ternary Cubic Equation
Authors: Janaki G. , Rahini J.
Published: March 2023

Abstract: The non-homogenous cubic equation with three unknowns represented by the Diophantine equation ૜(࢞ ࢟ + ૛ ૛ ) − ࢠ૛૛૞ = (૚ + ࢟ + ࢞)૛ + (࢟࢞)૝ ૜ is analyzed for its patterns of stringfy integral solutions. A few interesting properties among the solutions and some special polygonal numbers are presented.
Trends in E-Commerce: Post Covid-19 Pandemic
Authors: Pandey Kumari Suchi , Singh Dr. Nandan
Published: March 2023

Abstract: The Covid-19 pandemic is the greatest global humanitarian challenge the world has faced. The coronavirus profoundly transformed the global trends. These variations causative to the high adventitious and secondary funds that reflected for this virus. The purpose of this conceptual paper is to discuss the e-commerce trends predicament as well as how imminent progress in this have affected the consumer behaviour post pandemic.E- commerce has grown exponentially putting a strain on traditional brick and mortar stores. In today’s era it’s time to amplify our digital presence. This article will outline the impact of Covid-19 on e- commerce; how it has changed the key takeaway’s and trends to keep in mind when trying to form a digital business strategies that will appeal to post Covid consumers. Although the pandemic densely impacted economic activities and let to complete shutdown of some sectors it definitively helped in the surge of e-commerce and increased the use of digital transactions. This paper is made with an attempt to highlight, analyse and understand the Covid impact on the e-commerce as a whole .
Body Pose Estimation using Deep Learning
Authors: Mahajan Priyanshu , Gupta Shambhavi , Bhanushali Divya Kheraj
Published: March 2023

Abstract: Healthcare, sports analysis, gaming, and entertain- ment are just some of the many fields that could benefit from solving the challenging issue of real-time human pose detection and recognition in computer vision. Capturing human motion, analysing physical exercise, and giving feedback on performance can all benefit from reliable detection and recognition of body poses. The recent progress in deep learning has made it possible to create real-time systems that can accurately and quickly recognise and identify human poses.