bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring a New Methodology for Studying Korean Ancient History Using Network Analysis: Focusing on negotiation data from the Eastern Jin and Sixteen Kingdoms to the Song and Northern Wei period
Authors: Lim Dongmin
Published: August 2023

Network analysis is a methodology that helps understand complex phenomena by visualizing member interactions. In the context of Eastern Jin, Sixteen Kingdoms, Song, Northern Wei period, network analysis can shed light on the position of Paekche and Koguryŏ by analyzing negotiation networks. While existing studies have focused on negotiations between these states and China, few have visualized the entire negotiation network or compared the positions of Paekche and Koguryŏ within the broader East Asian network. This paper explores the network analysis methodology for ancient East Asian negotiation data and conducts a pilot analysis of specific periods.
The methodology for applying network analysis to ancient history involves several steps, including evaluating its suitability, quantifying the data, verifying data reliability, and analyzing and visualizing the data. Limitations of using network analysis to study ancient history include obtaining sufficient data and verifying data reliability. Ancient East Asian negotiation data is relatively more abundant than other records, making it a good candidate for network analysis. However, because negotiation data is recorded from the perspective of various actors, it is essential to verify the reliability of the data by ancient history researchers.
This paper theoretically analyzes the negotiation data of the Eastern Jin, Sixteen Kingdoms, Song, and Northern Wei periods. The negotiation network analysis reveals that Eastern Jin is the most centralized country, with Koguryŏ actively engaging in negotiations and Paekche focusing on diplomacy with Eastern Jin. The centrality analysis on the negotiation frequency data during Song and Northern Wei period shows that the Song and Northern Wei had the highest centrality in negotiation frequency among 28 countries, with Koguryŏ, Tuyuhun, and Paekche also prominent. The negotiation route analysis reveals the flow of information, with the Song having the highest betweenness centrality, Koguryŏ serving as a conduit to Shilla, and Paekche controlling the route to Mahan, Kaya, and Wa. Paekche plays a crucial role as a conduit between various regions, despite having lower centrality than Koguryŏ.
In conclusion, this paper explored the methodology of applying network analysis to ancient East Asian negotiation data and attempted to understand the structural structure of ancient East Asian negotiation networks by analyzing negotiation data from a specific time period.
Short read lengths recover ecological patterns in 16S rRNA gene amplicon data
Authors: Jurburg Stephanie
Published: August 2023

Metabarcoding is an increasingly popular and accessible method for
assessing bacterial communities across a wide range of environments, and
as the sequence data archives grow, sequence data reuse will likely
become an important source of novel insights into the ecology of
microbes. While literature on the benefits of longer read lengths for
the study of microbial communities, little is known about the
(re)usability of shorter (<200 bp) read lengths, but this
information is essential to improve the reuse and comparability of
metabarcoding data across studies. This study reanalyzed three 16S rRNA
datasets targeting aquatic, animal-associated, and soil microbiomes, and
evaluated how processing the sequence data across a range of read
lengths affected the resulting taxonomic assignments, biodiversity
metrics, and differential (i.e., before-after treatment) analyses. Short
read lengths successfully recovered ecological patterns, and limited
increases in resolution were observed beyond 100 bp reads across
environments. Furthermore, abundance-weighted diversity metrics (e.g.,
Inverse Simpson index or Bray-Curtis dissimilarities) were more robust
to variation in read lengths. Importantly, the total number of ASVs
detected increased with read length, highlighting the need to consider
metabarcoding-derived diversity estimates within the context of the
bioinformatics parameters selected. This study provides evidence-based
guidelines for the processing of short reads.
Examining the Relationship between Fear of COVID-19 and Absenteeism among Frontline Workers in Pakistan
Authors: Abbas Qamar , Rehman Abdul , Jamil Sobia , Khan Anum , Asad Zainab
Published: August 2023

One of the significant difficulties businesses worldwide have encountered due to the spread of COVID-19 is the absence of essential employees. The major purpose of this research study was to assess the effect that anxiety brought on by the Covid-19 outbreak had on the percentage of workers who were absent from their jobs. In addition, this study aimed to evaluate the role that psychological distress and perceived organization support play as mediators and moderators between the fear of Covid-19 and absenteeism on the part of employees in the exposition of P-E Fit theory. With a quantitative research method and deductive approach, Data was collected using a validated survey instrument, with 239 responses received through an online Google form. The study's focus group consisted of frontline sales representatives. Using Smart-PLS to test the hypotheses revealed that most could be accepted. These findings are consistent with previous research studies in the field. This research adds to the previous literature by addressing the significance of managers' support for frontline staff by supplying them with the required tools and supplies to decrease fear and stress in the face of Covid-19. Overall, the study highlights the significant impact of the pandemic on the workplace and underscores the importance of understanding the factors that influence employee behavior during these unprecedented times.
The sensitivity of plantar warts to roentgen radiation.
Authors: Reymann F.
Published: August 2023

No abstract available
Incontinentia pigmenti in a newborn boy.
Authors: Pallisgaard G.
Published: August 2023

No abstract available
Cellular changes in the psoriatic epidermis. VII. The influence of mercury
Authors: Frithz A , Lagerholm B.
Published: August 2023

No abstract available
Passive transfer to human recipients of the capillarotoxic serum factor
Authors: Kozlowski J , Malaszynska-Olkiewicz E.
Published: August 2023

No abstract available
Allergy to copper derived from dental alloys as a possible cause of oral lesions
Authors: Frykholm KO , Frithiof L , Fernström AI , Moberger G , Blohm SG Björn
Published: August 2023

No abstract available
Housewives' eczema and the role of chromates.
Authors: Feuerman EJ.
Published: August 2023

No abstract available
The fluorescent treponemal antibody-absorption test (FTA-ABS) in treated latent
Authors: Förström L , Lassus A.
Published: August 2023

No abstract available
Atypical cutaneous herpes simplex infection associated with acute myelogenous
Authors: Bean SF , Fusaro RM.
Published: August 2023

No abstract available
Syphilis of the lung. A case report and discussion of its clinical diagnosis.
Authors: Haim S , Shafrir A , Sasson Y.
Published: August 2023

No abstract available
Colloid bodies in dermatoses other than lichen planus
Authors: Sümegi I.
Published: August 2023

In a previous study on lichen planus the morphology and significance of the colloid bodies were discussed (13). In the present study a description is given of 30 dermatoses with colloid bodies, observed among unselected patients. The colloid bodies develop as a result of damage to the epithelium caused by circulatory disorders with subsequent hypo- or anoxia. Lichenoid cell infiltration into the connective tissue--nearly always present--aggravates the process. Dyskeratosis, pyknosis and fibrinoid necrosis of the damaged cells occur and the nuclei disintegrate. The resultant colloid bodies may coalesce or scatter or be expelled from the epithelium according to the principles of apoptosis (6, 7). Besides circulatory disorders, purely local damage and pathological processes involving the tissues should be regarded as important factors. Although the colloid bodies are characteristic for various skin diseases, they do not have an absolutely clear diagnostic significance. In doubtful cases their presence may nevertheless be considered a valuable contribution and supplement to the diagnosis.
Influence of ultraviolet light on itch and flare reactions in human skin induced by histamine and the histamine liberator compound 48/80
Authors: Fjellner B. , Hägermark O.
Published: August 2023

The itch and flare responses induced by intradermal injection of histamine and the histamine liberator compound 48/80 were studied in healthy volunteers before and after exposure to UVB, UVA or PUVA administered 2-3 times weekly for 4 weeks. All three modalities were found to inhibit the responses induced by compound 48/80. The degree of tanning was most pronounced after PUVA and weakest after UVB, without any correlation between tanning and inhibition of itch. In contrast, when induced by histamine, the responses were not inhibited to the same extent, pronounced and significant inhibition being observed only for itching in subjects exposed to UVB. It is concluded that UVB, UVA and PUVA all might be of benefit in treating pruritic states if histamine release is involved and that UVB might have an additional effect by inducing hyposensitivity to itching stimuli.
Erythema craquelé provoked by corticosteroids on normal skin
Authors: Björnberg A.
Published: August 2023

The provocation of erythema craquel√© after cessation of long-term continuous steroid application to normal skin was investigated in 58 healthy subjects, usually under occlusion. No correlation was demonstrated between the erythema craquel√© and skinfold thickness measured with the Harpenden technique.
Occurrence of Trichophyton tonsurans infections in the Danish island of Funen
Authors: Foged EK. , Sylvest B.
Published: August 2023

During the period from 1977 to 1980 eleven cases of T. tonsurans infections were diagnosed in the Mycology Laboratory, Department of Dermatology and Venereology, Odense University Hospital, Denmark. All patients were adults and none had tinea capitis. Five patients had tinea pedis, 5 tinea ungvium, 2 tinea cruris, one tinea manuum, and one tinea glabrosa.
Oral retinoid in combination with bleomycin, cyclophosphamide, prednisone and transfer factor in mycosis fungoides
Authors: Zachariae H. , Grunnet E. , Thestrup-Pedersen K. , Molin L. , Schmidt H. , Starfelt F. , Thomsen K.
Published: August 2023

Oral retinoids seem to have been of great benefit in a non-randomized study on advanced mycosis fungoides using two different chemotherapy regimens, one with retinoid, the other without. Both groups also received a 3-drug chemotherapy with bleomycin, cyclophosphamide and prednisone. Complete remission including all signs of lymph-node involvement was found in 8 of 10 patients of the retinoid treated group, while none went into complete remission in the control group. All in the control group died between 3 and 12 months after therapy, whereas all but one in the retinoid treated group are alive. Other treatment differences between the groups were related to the use of transfer factor, topical treatment, and steroid administration. These differences make a final evaluation of the use of retinoids in mycosis fungoides difficult at the present stage. Further studies are needed.
Inhibited proliferation of human scleroderma skin fibroblasts and rheumatoid synovial cells with griseofulvin in vitro
Authors: Priestley GC. , Brown JC.
Published: August 2023

Griseofulvin at 2-17 micrograms/ml in in vitro inhibited the proliferation of scleroderma skin fibroblasts and rheumatoid synovial cells. The inhibition was concentration-dependent, with little difference between the two types of cells. Mean ID50 values from the four strains of each group were 9.2 for fibroblasts and 9.5 for synovial cells. The results show that griseofulvin at therapeutic concentrations can have a direct effect on the growth of cells cultured from diseased human connective tissues.
Blood glutathione-peroxidase levels in skin diseases: effect of selenium and vitamin E treatment
Authors: Juhlin L. , Edqvist LE. , Ekman LG. , Ljunghall K. , Olsson M.
Published: August 2023

Blood glutathione-peroxidase (GSH-Px) was determined in 61 healthy subjects and 506 patients with various skin disorders. Depressed levels were observed in patients with psoriasis, eczema, atopic dermatitis, vasculitis, mycosis fungoides and dermatitis herpetiformis. Low values of GSH-Px were also found in some patients with pemphigoid, acne conglobata, polymyositis, rheumatoid arthritis, scleroderma and systemic lupus erythematodes. Vegetarian diet, malnutrition and alcohol abuse could possibly account for the low values in some patients. Fifty patients with low GSH-Px levels were treated with tablets containing 0.2 mg selenium as Na2SeO3 and 10 mg tocopheryl succinate. The GSH-Px levels increased slowly within 6-8 weeks of treatment. The clinical effect was encouraging and calls for controlled studies.
Psoriasis in monozygotic twins: variations in expression in individuals with identical genetic constitution
Authors: Brandrup F. , Holm N. , Grunnet N. , Henningsen K. , Hansen HE.
Published: August 2023

The variation in expression of psoriasis, in individuals with identical genetic constitutions, i.e. monozygotic twins, has been studied in a population-based sample of monozygotic twins in the Danish Twin Register. All verified and probable cases of psoriasis in twins, born between 1891 and 1930 inclusive, were ascertained. Results are presented of an examination of all members of index pairs in which both partners were alive. The zygosity determination was based in 94% of the pairs on very extensive serological examinations. Thirty-two monozygotic pairs were found to include at least one partner with unquestionable psoriasis (18 concordant, 14 discordant). The analyses give firm evidence of the contribution of genetic factors to the manifestation, age at onset, clinical type, course, and severity of psoriasis. A close association between psoriasis and HLA-B 13 an B 17 was found in both discordant and concordant pairs. No difference was found between partners from discordant MZ-pairs with regard to infections or marked ´stress´ conditions.
Immunological markers of Langerhans´ cells in mycosis fungoides skin lesions
Authors: Tjernlund U.
Published: August 2023

The patterns of two immunological markers of epidermal Langerhans´ cells were compared in normal skin and mycosis fungoides (MF) skin lesions. A double-staining indirect immunofluorescence method was used. Cells suggestive of keratinocytes reacted with the anti-Ia antibodies in some cases of MF lesions, while no such pattern was seen with the thymocyte-antigen antibodies (OK T6). In other cases of MF, as in normal skin, the epidermal picture was mainly the same with the two markers. A great many of the dermal mononuclear cells in MF were reactive with the anti-Ia antibodies but only occasional dermal cells in MF and no dermal cells in normal skin stained with OK T6.
Thiol levels in normal and psoriatic corneocytes
Authors: Mier PD. , Van Rennes H.
Published: August 2023

No abstract available.
Immunofluorescence studies on C1Q in mast cells
Authors: Igarashi R. , Sudo S. , Morohashi M. , Takeuchi S. , Sato Y.
Published: August 2023

Evidence has been obtained of deposition of complement component C1q in mast cells, by the immunofluorscence technique, using biopsy specimens from the scalp from 5 of 7 normal subjects and 14 of 17 patients with alopecia areata and also from skin lesions of 1 of 2 patients with urticaria pigmentosa studied. The fluorescence in mast cells was of a granular pattern in most instances. No deposition of immunoglobulins (IgG, IgA, IgM, IgE) or other complement components (C3, C4, C5, C9) was demonstrable in the mast cells. The specificity of the C1q deposition in mast cells was confirmed by various tests, viz., the blocking test, prerinsing of tissue sections with bovine serum albumin-containing phosphate-buffered saline, absorption test of conjugates, C1q destruction test with urea or by heating, and the Ouchterlony method.
Ketoconazole in Trichophyton rubrum
Authors: Laurberg G.
Published: August 2023

10 patients with T. rubrum infection were treated with Ketoconazole 200-400 mg a day for 8 weeks. All patients had a skin infection and 2 in addition infection of the toe nails. Previous treatment with Griseofulvin and at least two different antifungal topicals had been ineffective. The infection was evaluated by clinical findings and mycological examination. The skin lesions disappeared in 6 patients, while none of the nail lesions were cured. However, at a follow-up 2 months after the end of the Ketonocazole treatment, recurrence was observed in 3 of 6 patients. It is suggested that Ketoconazole treatment of previously resistant T. rubrum infection should be continued for more than 2 months.
Chronic active hepatitis and lichen planus
Authors: Rebora A. , Rongioletti F. , Canepa A.
Published: August 2023

No abstract available.
Nickel allergy and hand dermatitis in a stratified sample of the Danish female population: an epidemiological study including a statistic appendix
Authors: Menné T. , Borgan O. , Green A.
Published: August 2023

The occurrence of nickel allergy and hand eczema has been investigated in a stratified sample (2 500) of the Danish female population by an interview technique. The incidence density (allergy intensity) has been estimated by standard maximum likelihood methods. The age-specific prevalence rates have been calculated by life table techniques. The incidence density has doubled in all age groups from 1948 to 1973. The highest prevalence rate of nickel allergy was found in the 45-year-olds (0.189 +/- 0.023). The possible interaction between nickel allergy and hand eczema was analysed by a Markov chain model. Compared with non-nickel-sensitive women, a woman who has become nickel sensitized ran an increased risk of developing hand eczema. And those who had first developed hand eczema ran an increased risk of subsequently developing nickel allergy. In future efforts to reduce direct skin contact with nickel, the close relation between nickel allergy and hand eczema should be the main argument. Statistical methods based on the incidence density will be useful in the evaluation of these efforts.
Razoxane in the treatment of psoriatic patients resistant to or intolerant of PUVA, methotrexate and etretinate
Authors: Mom A. , Aresca S. , Fuente G. , Pecorini V. , Pellerano G. , Perez V.
Published: August 2023

Thirty-six psoriatic patients resistant to or intolerant to PUVA, methotrexate and/or etretinate were treated with razoxane (ICRF 159) and EDTA derivative with antimitotic effects. The drug is highly effective in cutaneous and arthropathic psoriasis. Razoxane is well tolerated and appears to be free of hepatotoxicity. Besides some nausea and lethargy, 60% of the patients showed neutropenia, which can be easily controlled.
Accidental induction of photocontact allergy to Heracleum laciniatum
Authors: Kavli G. , Volden G. , Raa J.
Published: August 2023

Photocontact allergy to psoralens in Heracleum laciniatum occurred in two persons volunteering for investigations into phototoxicity of plant homogenates and purified psoralens. Photoallergy was noted following the fifth exposure in case 1, and the sixth in case 2. Testing with diluted solutions demonstrated allergy to sphondin, isobergapten and pimpinellin.
Methotrexate in psoriasis with and without leucovorin: effect of different dosage schedules on acute liver toxicity
Authors: Zachariae H. , Bjerring P.
Published: August 2023

Studies on thirty-six psoriatics revealed no differences in acute liver toxicity of four different intermittent dosage schedules of methotrexate with or without addition of leucovorin, as judged by daily determinations of SGOT for one week. Three patients with psoriatic erythroderma receiving high-dosage methotrexate (100 mg i.v.) with leucovorin rescue responded extremely well to treatment and did not distinguish themselves from the other patients with regard to acute liver toxicity.
A rosacea-like eruption induced by Tigason (Ro 10-9359) treatment
Authors: Crivellato E.
Published: August 2023

A 67-year-old male patient, with a history of palmar psoriasis for 8 years, developed a rosacea-like eruption during Tigason (Ro-10-9359) treatment. Strict relationship between Tigason intake and skin symptoms was proved by double introduction of the drug and the patient´s previous history. This retinoid side effect is very unusual and we are unable to give any explanation for it.
Herpes simplex infection simulating a positive auto-inoculation for Haemophilus ducreyi
Authors: Jørgensen J. , Menné T.
Published: August 2023

Auto-inoculation from a genital ulcer suspected of being ulcus molle gave redness after 24 hours and after 48 hours vesicles and pustules appeared. Cultivation from the auto-inoculation after the 48 hours was positive for herpes simplex virus type 2. Our observation underlines two points: auto-inoculation for the diagnosing of Haemophilus ducreyi infection may be mimicked by herpes simplex infection, and the incubation period of herpes simplex can be shorter than the 4-5 days usually given.
T lymphocyte subsets in the duodenal epithelium in dermatitis herpetiformis
Authors: Ljunghall K. , Lööf L. , Forsum U.
Published: August 2023

Monoclonal antibodies to human T lymphocyte subsets and HLA-DR antigens were used to characterize the intra-epithelial T lymphocytes and HLA-DR reactive cells in the duodenal epithelium in dermatitis herpetiformis (DH). The expression of HLA-DR antigens on the epithelial cells was similar in patients and controls. There were significantly more Leu 2a (suppressor/ cytotoxic phenotype) reactive cells, as related to epithelial length, in 7 patients with DH than in the epithelium of 5 controls. However, the ratio of Leu 2a (suppressor/cytotoxic phenotype) to Leu 3a (helper/inducer phenotype) reactive cells was the same in the patients as in the controls. Thus this study indicates that there is a quantitative rather than a qualitative difference in T lymphocyte subpopulations in duodenal epithelium between patients with DH and normal persons.
Decreased lymphocyte aryl hydrocarbon hydroxylase and glutathione S-transferase activities in patients with hand dermatitis
Authors: Singh N. , Hamann K. , Clausen J.
Published: August 2023

Aryl hydrocarbon hydroxylase (AHH) and glutathione S-transferase (GST) (EC 2.5.1.18) activity were measured in human lymphocytes of peripheral blood from 8 patients with irritant or allergic contact dermatitis of the hands, and compared with data from a control group. Both AHH and GST activity was found to be significantly depressed in the allergic and irritant contact dermatitis subjects, as compared with controls. It is suggested that AHH may be a quantitative marker of the inflammatory status.
Acral syringoma: electron microscopic studies on its origin
Authors: Asai Y. , Ishii M. , Hamada T.
Published: August 2023

A case of acral syringoma associated with the usual eruption on the lower eyelids was examined by light and electron microscopy for the first time. In the upper dermis there were a few ducts and cystic formation, while predominant atypical solid strands composed of tumor cells were often seen by light microscopy. Electron microscopy showed the formation of small ducts in the solid strands and numerous microvilli with a pinching off of the luminal tumor cells. A large number of multivesicular dense bodies (mvb) and keratohyalin granules were also found in the periluminal tumor cells. The ducts resembled embryonic intra-epidermal ducts. The unusual anatomical sites of eruption and the electron microscopic findings suggest an eccrine intra-epidermal duct origin of acral syringoma.
Immunoglobulin and complement deposits in the skin and circulating immune complexes in scabies
Authors: Salo OP. , Reunala T. , Kalimo K. , Rantanen T.
Published: August 2023

Sixteen patients with papulovesicular, 6 with nodular and one with a Norwegian scabies were studied. Direct immunofluorescence (IF) examination revealed C3 deposits in the skin lesions of 13 of the 18 patients. Among them were all 6 cases with nodular scabies. C3 was found mostly in dermal vessel walls and 3 of the patients also showed IgM and 2 IgA deposits at the same site. No circulating immune complexes were found, with a solid-phase C1q radioimmunoassay (RIA), but HSV- and RSV-RIA methods detected IgM antibodies of rheumatoid factor type in 5 of the 15 sera examined. These results suggest that local complement activation and perhaps also immune complex deposition may by important in the pathogenesis of the papular and nodular skin lesions of human scabies.
Normal sweating and tear production in congenital ichthyosiform erythroderma with deafness and keratitis
Authors: Van Everdingen JJ.  , Rampen FH. , Van der Schaar WW.
Published: August 2023

A 24-year-old female patient with congenital ichthyosiform erythroderma, deafness and vascularizing keratitis yet also examining normal sweating and tear production when tested is reported. This unique finding indicates that a certain subgroup of patients with this generalized ectodermal disturbance may benefit from treatment with the aromatic retinoids.
Contact urticaria to wheat bran bath: a case report
Authors: Langeland T. , Nyrud M.
Published: August 2023

No abstract available.
Dermatitis herpetiformis: effect of gluten-restricted and gluten-free diet on dapsone requirement and on IgA and C3 deposits in uninvolved skin
Authors: Ljunghall K. , Tjernlund U.
Published: August 2023

Of 58 patients wi1h classical dermatitis her­petiformis (DH), I 7 were rreatcd with a gluten-frec diet (GFD) for periods varying from 6 to 47 months and 11 with a gluten-reduced diet (GRD) for 7 to 29 months. The patients were able to reduce their requirement of dapsone significantly compared with 30 patients on a normal diet, of whom only an 86-year-old man was able to discontinue his JO mg dapsonc dose. In 7 of the 17 patients on GFD. dapsone could be completely withdrawn after diet periods of 4 10 38 month
Skin photosensitizing and Langerhans´ cell depleting activity of topical (bath) PUVA therapy: comparison of trimethylpsoralen and 8-methoxypsoralen
Authors: Koulu L. , Jansén CT.
Published: August 2023

The skin photosensitizing and Langerhans´ cell (LC) depleting effects of a single bath PUVA exposure were studied in 22 healthy young volunteers. The photosensitizing effect of bathing for 15 min in a 0.2 mg/1 trioxsalen-water solution was about 30 times as great as a similar treatment in an equipotent methoxsalen solution. The skin erythema induced by methoxsalen bath PUVA peaked on day 2 and diminished thereafter, whereas the trioxsalen reaction showed a broad plateau on days 2-5 after the irradiation. A reduction in LC density to about 30-40% of the starting value was seen in both trioxsalen and methoxsalen bath PUVA treated skin sites on day 4 after irradiation, and low or diminishing LC counts prevailed until day 10-11. The amount of UVA needed to produce a similar degree of LC depletion was 15-30 times as great in the case of methoxsalen, compared with trioxsalen. A perceptible erythema reaction, however, was, not a prerequisite for a reduction in LC density.
Effect of betamethasone valerate on the normal human facial skin flora
Authors: Daltrey DC. , Cunliffe WJ.
Published: August 2023

Eighteen volunteers were randomly divided into two groups and allocated either an active corticosteroid preparation (Betamethasone valerate) or the basal formulation only (placebo). The cream was applied to the face twice daily for one month. The treated area was sampled by the scrub-wash method immediately before treatment began and after 2 and 4 weeks, and microorganisms were enumerated and identified. Application of either cream produced a very slight increase (less than or equal to 0.5 log cycle) in the skin flora during the first 2 weeks of treatment. There were no significant differences in the changes occurring between volunteers treated with placebo and those on the steroid formulation. The results are discussed in relation to theories of pathogenesis of perioral dermatitis and steroid acne.
Keratodermia punctata hereditaria treated with etretinate (Tigason)
Authors: Christiansen JV.
Published: August 2023

No abstract available.
Ear ache during etretinate treatment
Authors: Juhlin L.
Published: August 2023

No abstract available.
Involvement of post-capillary venules in Beh√ßet´s disease: an electronmicroscopic study
Authors: Clausen J. , Bierring F.
Published: August 2023

In Beh√ßet´s disease, severe pathological changes are observed in the post-capillary venules, indicating that the venous side of the circulation is generally involved. It is proposed that one of the initial pathological changes is multiplication of the basal lamina surrounding the post-capillary venule.
Decubitus prophylaxis: a prospective trial on the efficiency of alternating-pressure air-mattresses and water-mattresses
Authors: Andersen KE. , Jensen O. , Kvorning SA. , Bach E.
Published: August 2023

Six hundred patients at risk for pressure sores were randomized in either a control group or one of two experimental groups placed on alternating-pressure air-mattresses and water-mattresses. The groups remained comparable throughout the 10-day study period. Twenty-one patients from the control group developed decubitus ulcers, compared with 7 in each of the other groups. Patient and ward personnel opinions on the acceptability of the three types of mattresses were registered.
The effect of H1 and H2 receptor antagonists on the dermographic response
Authors: Cook J. , Shuster S.
Published: August 2023

The effect on dermographic wealing of an H1 and H2 receptor antagonist was studied separately and in combination. a double-blind protocol was used and dermographism was measured as the diameter of weal response to a measured force. Both H1 and H2 antagonists had a small but non-significant effect, but the combination of H1 plus H2 antagonist had an approximately additive effect which was significant. Although this indicates a role for H2 receptors in dermographism it does not establish the degree of involvement, nor whether H2 antagonists necessarily have any advantage over a potent H1 blocker alone in the treatment of dermographism.
"Keratosis palmoplantar striata" (Brunauer-Fuhs type)
Authors: Ortega M. , Quintana J. , Camacho F.
Published: August 2023

No abstract available.
Aneuploidy in cutaneous T-cell lymphoma
Authors: Lange Wantzin G. , Larsen JK. , Christensen IJ. , Bruun Rasmussen B. , Thomsen K.
Published: August 2023

A new method is described which makes it possible using skin specimens to perform flow cytometric analysis of DNA content. DNA content analysis was performed on 28 skin specimens and 9 blood samples from 18 patients with mycosis fungoides and S√©zary syndrome. The reproducibility was fair, with almost identical results in 6 cases (mycosis fungoides and S√©zary syndrome) where two samples (skin specimens or blood samples) were taken 6 hours to 10 days apart. Hyperdiploidy was found in 7 of 11 skin specimens from patients with mycosis fungoides stage I with negative histology. In 13 skin specimens and 3 blood samples from patients with mycosis fungoides stages II and IV, abnormalities including hyperdiploidy, near-tetraploidy and near-hexaploidy were found in 8 of 13 skin specimens and in 2 of 3 blood samples. Four patients with S√©zary syndrome were studied: 2 patients in remission showed normal DNA histograms (2 skin specimens, 3 blood samples) and 2 patients with active disease showed aneuploidy in the 2 skin specimens examined and in 1 of 3 blood samples. These studies demonstrate: 1) the importance of flow cytometry as a diagnostic tool for use on skin specimens in the early stages of mycosis fungoides where routine histology is non-diagnostic; 2) the diagnostic and prognostic aid of flow cytometry during the course of mycosis fungoides and S√©zary syndrome in addition to the probability of measuring the effect of treatment.
Contact allergy to parthenolide in Tanacetum parthenium (L.) Schulz-Bip. (feverfew, Asteraceae) and cross-reactions to related sesquiterpene lactone containing Compositae species
Authors: Hausen BM. , Osmundsen PE.
Published: August 2023

A case of specific, delayed hypersensitivity induced by repeated contact with a wild form of feverfew (Tanacetum parthenium) is reported. In the flowers investigated the content of the responsible contact allergen parthenolide--a potent sesquiterpene lactone--appeared to be 10 times greater (0.6-0.9%) than in earlier years. Guinea pig experiments confirm the strong sensitizing potency of this Compositae species. Cross-reactions were elicited with 11 of 21 mostly Compositae plants containing chemically related sesquiterpene lactones. The strongest reactions were elicited by tansy, yarrow (milfoil), marguerite, aster, sunflower, laurel and Frullania. Structure elucidation by X-ray crystallographic analysis established the precise molecule configuration of parthenolide, although the lattice parameters of the isolated compound were not in accordance with those published in the literature.
The immediate action of long-wave ultraviolet radiation (UVA) on suprabasal melanocytes in human skin: a transmission electron microscopical study
Authors: Beitner H. , Wennersten G.
Published: August 2023

The immediate effects of long-wave ultraviolet irradiation (UVA) in non-erythemal doses on suprabasal melanocytes in normal skin of healthy caucasians with skin types II and III was investigated with the transmission electron microscopy (TEM) in order to detect possible morphological changes. In skin type III the melanocytes remained essentially unaltered, but in skin type II, multiple pinocytotic vesicles, large vacuoles, swelling, and partial to total dissolution of the inner membranes of the mitochondria and numerous small vesicles associated with an enlarged Golgi apparatus were observed after 3.6 to 14.5 J/cm2 of UVA irradiation. No IPD reaction was observed in any of the subjects with skin type II irradiated with UVA up to 20 J/cm2.
Pregnancy as a trigger of epidermolysis bullosa acquisita
Authors: Kero M. , Niemi KM. , Kanerva L.
Published: August 2023

A 38-year-old woman developed epidermolysis bullosa acquisita (A-EBD) in connection with her third pregnancy. The activity of visible blistering disappeared at menopause. Direct immunofluorescence examination showed linear deposition of IgG and C´3 in the basement membrane zone. The light and electron microscopical findings of the disease were consistent with A-EBD. We assume that the bullous scarring eruption was triggered by a hormonal mechanism.
T and B lymphocytes, macrophages and Langerhans´ cells during the course of contact allergic and irritant skin reactions in man
Authors: Ranki A. , Kanerva L. , Förström L. , Konttinen Y. , Mustakallio KK.
Published: August 2023

The in situ distribution of lymphocyte subclasses, macrophages and Langerhans´ cells was analysed with histochemical (ANAE staining), immunohistochemical (immunoperoxidase) and electron microscopic methods during the course of epicutaneous allergic and irritant skin reactions. Serial biopsies were taken during the first 5-72 hours following the allergen (nickel and chromium) or irritant (non-anoic acid and dithranol) application. Empty and petrolatum-filled Finn chambers were used as controls. No significant differences in the number of mononuclear inflammatory cells or their subclasses were found in the early recognition and elicitation phases of the allergic or irritant-induced reactions. Nor was there any difference in the frequency of lymphocyte-Langerhans´ cell contacts, although exocytic cells were most frequent in dithranol reactions.
Growth and filament production of Pityrosporum orbiculare and P. ovale on human stratum corneum in vitro
Authors: Faergemann J. , Aly R. , Maibach HI.
Published: August 2023

When Pityrosporum orbiculare and P. ovale were incubated with stratum corneum epithelial cells, suspended in phosphate-buffered saline for 90 min at 37 degrees C, short filaments were produced in 11-17.5% of the yeast cells. A successful culture of P. orbiculare and P. ovale on human stratum corneum in vitro is described. When the stratum corneum pieces were incubated for 5 days in an environment with 7% CO2, a picture resembling that seen microscopically in tinea versicolor was observed. Filaments were produced in 39-48% of P. orbiculare and P. ovale cells; the longest pseudohyphae, 40-60 microns, were produced by P. ovale. This culture method provides the possibility of studying the parasitic mycelium form of P. orbiculare and P. ovale in vitro. The influence of antimycotics, other drugs, and interaction with other microorganisms can be studied.
Demonstration of beta 1H globulin in pemphigus
Authors: Nishikawa T. , Sugiura M. , Hashimoto T. , Kurihara S. , Tamura N.
Published: August 2023

beta 1H globulin is a plasma protein which regulates the biologic activities of the major fragment of the 3rd complement component, C3b. The role of beta 1H globulin in pemphigus was investigated using immunofluorescence in the present study. Lesional skin biopsies from patients with confirmed pemphigus demonstrated in-vivo deposition of beta 1H in addition to C3 in all of four biopsies. Eight serum samples containing C3 fixing intercellular antibodies were then tested for the capacity to fix beta 1H and other complement components. All eight pemphigus sera showed fixation of beta 1H to the intercellular areas of normal human skin. C1q and C4 fixation by pemphigus sera was also demonstrated in 7 of 8 sera, respectively. The experiment using C2-deficient serum indicated that the fixation of beta 1H by intercellular antibodies requires the activation of the classical complement pathway. These data suggested that beta 1H, a co-factor of C3b inactivator, plays a role in the in-vivo regulation of complement activity and supplies additional evidence for the participation of complement system in the pathogenesis of pemphigus.
Dermatophytid--a misdiagnosed entity?
Authors: Kaaman T. , Torssander J.
Published: August 2023

A mycological and immunological survey was performed in 26 patients with clinical signs of dermatophytid. Only 10 patients fulfilled the main criteria of dermatophytid reactions, i.e. positive delayed skin test to trichophytin and dermatophyte isolated by culture. Trichophyton mentagrophytes--especially the zoophilic variant--was found in 9 patients of 10. In the majority of cases, inflammatory tinea pedis caused the dermatophytid reaction which appeared as vesicles localized to the palms. Relying on clinical appearance only implies an obvious risk of erroneously including pyoderma and various eczemas, e.g. pompholyx and contact dermatitis, as dermatophytids. Mycological culture and skin test with a reliable trichophytin antigen preparation ought to be applied in order to avoid misdiagnosis.
An analysis of T-lymphocyte subpopulations in psoriasis using monoclonal antibodies
Authors: Kokelj F. , Perticarari S. , Presani G. , Trevisan G.
Published: August 2023

We evaluated subpopulations of T-lymphocytes by using the monoclonal antibodies OKT3, OKT4 and OKT8 in two groups of psoriatic patients, with active and stable psoriasis respectively. Whereas data from the patients with stable psoriasis were similar to those obtained from the control group, the patients in an acute flare condition revealed a relative decrease in lymphocytes reactive with OKT8, and a slight increase in the proportion of lymphocytes reactive with OKT4. The results of this study are analysed.
Prostaglandins in contact urticaria induced by benzoic acid
Authors: Lahti A. , Oikarinen A. , Viinikka L. , Ylikorkala O. , Hannuksela M.
Published: August 2023

To study the role played by prostaglandins (PGs) in contact urticaria, concentrations of 13,14-dihydro-15-keto-PGF2 alpha, 6-keto-PGF1 alpha, and thromboxane B2, the stable metabolites of PGF2 alpha, prostacycline and thromboxane A2 were measured by radio-immunoassay of the fluid taken from suction blisters in 11 patients. The blisters were raised on contact urticarial reactions induced by benzoic acid. The effect of peroral indomethacin on contact urticaria from benzoic acid was studied in a further 14 dermatological patients. The levels of these prostanoids in the blister fluid of urticarial skin did not differ from those derived from control blisters raised on apparently normal skin. Premedication with indomethacin, 50 mg t.i.d., completely prevented contact urticarial reactions to benzoic acid in all patients.
Onychomycosis in patients with psoriasis
Authors: Staberg B. , Gammeltoft M. , Onsberg P.
Published: August 2023

The frequency and type of fungal infections of the finger- and toenails was studied prospectively by direct microscopic and culture examinations in dermatological out-patients without psoriasis (n = 41), in patients with psoriasis but no nail involvement (n = 39), and in patients with both psoriasis and nail involvement (n = 39). In these three matched groups the frequencies of dermatophytic nail infections were 10%, 13%, and 13%, respectively, and the frequencies of yeast infections 10%, 10%, and 15%, respectively. These figures were not significantly different. It is concluded that dermatophytic invasion of involved psoriatic nails is not so rare as previously supposed. However, yeast infections are possibly more frequent in involved psoriatic nails as compared with uninvolved and normal nails.
Does long-term treatment with D-penicillamine alter calcium and phosphorus metabolism in patients with systemic sclerosis?
Authors: Hagdrup H. , Serup J. , Tvedegaard E.
Published: August 2023

Only animal experiments have been published regarding the possible effect of penicillamine treatment on mineral balance. We examined 35 patients with a diagnosis of systemic sclerosis treated with penicillamine, in comparison with 10 patients with systemic sclerosis treated with other collagen inhibitors (glutamine, hydralazine, phenytoin, chlorpromazine). The following laboratory tests were performed in all patients: the serum concentrations of calcium, ionized calcium, phosphorus and the parathyroid hormone. The 24-hour urinary excretions of calcium and phosphorus were determined. The bone mineral content of the distal radius was determined by photon-absorptiometry; radiological examination of the hands was performed to show aberrant calcifications. No differences were found between the two groups. A low urinary excretion of calcium and phosphor was found in the entire material. The bone mineral content was low in both groups. A high frequency of aberrant calcifications was not correlated to treatment with penicillamine.
Treatment of arsenical keratosis with etretinate
Authors: Sharma SC. , Simpson NB.
Published: August 2023

Treatment with oral etretinate is reported in a case of arsenical keratosis with Bowen´s disease. Good (80%) clearance in keratoses was obtained, which is maintained after 15 months´ follow up.
Protein-bound dopa and 5-S-cysteinyldopa in non-melanogenic tissues
Authors: Ito S. , Jimbow K. , Kato T. , Kiyota M. , Fujita K.
Published: August 2023

To explore the possibility that dopa and 5-S-cysteinyldopa, precursors of melanin, can be produced in non-melanogenic tissues, this study examined the contents of the free and protein-bound forms of two catechols in non-melanogenic tissues of mice and rats, and compared the urinary excretion of free catechols in black and albino mice. Considerable amounts of protein bound dopa and 5-S-cysteinyldopa were present in the hair of tyrosinase-negative, albino mice and white mice, the latter completely lacking follicular melanocytes. The liver, kidney and brain of mice and the adrenals of rats also contained small amounts of these catechols. Both black and albino mice excreted free dopa and 5-S-cysteinyldopa, the amounts of which did not differ significantly in the two animals. It is suggested that oxidation mechanism(s) other than tyrosinase may participate in the synthesis of these catechols in proteins. Turnover of 5-S-cysteinyldopa-containing proteins may lead to the release of this catechol into blood and eventually to excretion into urine.
Pemphigus antibodies mediate the development of an inflammatory change in the epidermis. A possible mechanism underlying the feature of eosinophilic spongiosis
Authors: Iwatsuki K. , Tagami H. , Yamada M.
Published: August 2023

The interaction between complement-fixing pemphigus antibodies and leukocytes was investigated by the in vitro leukocyte attachment test. Attachment of eosinophils as well as neutrophils was induced by pemphigus antibodies at the intercellular space of epidermis in the presence of complement. This phenomenon was found to be produced by 7 out of 10 pemphigus sera in the indirect method using non-lesional skin as a substrate, and in 2 out of 7 biopsy specimens taken from perilesional skin without addition of any sera by the direct method. Those leukocytes bound specifically to the epidermis showed an enhanced function. i.e., vigorous incorporation of nitroblue tetrazolium dye complexes and formation of formazan crystals in the cytoplasms. The results of the present studies suggest that complement-fixing pemphigus antibodies mediate the development of an inflammatory change by inducing an infiltration of polymorphs in the epidermis, which is noted as eosinophilic spongiosis histologically.
Irritation and staining by dithranol (anthralin) and related compounds. IV. Visual estimation of erythema compared with contact thermometry and laser Doppler flowmetry
Authors: Mustakallio KK. , Kolari PJ.
Published: August 2023

Irritation and staining caused by equi-irritant doses of dithranol (anthralin) and 10-butyryl dithranol (butantrone) were observed for one week after a single 24-hour exposure under occlusion. The test chambers were applied on the uninvolved dorsal skin of 11 psoriasis patients. The estimates of erythema were made with a refined reading scale, and to test the visual discriminatory power they were compared with objective measurements of contact temperature and blood flow of the skin. A sensitive thermistor and a novel laser Doppler flowmeter were used. On the whole, erythema, contact temperature and superficial blood flow, as interdependent parameters of cutaneous inflammation, all showed a time-dependent statistically significant correlation to the dose of dithranol and 10-butyryl dithranol. The intercorrelations between erythema and blood flow and between erythema and temperature were statistically significant, too. With the doses used, staining of the skin did not hamper the measurement of superficial blood flow, but it did exaggerate visual estimates of erythema at the 4th and 7th day readings.
Bestatin therapy of patients with atopic dermatitis
Authors: Thestrup-Pedersen K. , Cramers M. , Kongsholm H. , Zachariae H.
Published: August 2023

Ten adult patients with severe atopic dermatitis were treated for three months with estatin, which is a metabolite of Streptomyces olivoreticuli. Bestatin has been shown to increase tumor resistance in mice, augment a variety of immune responses and to reduce the level of IgE in non-atopic healthy persons. During bestatin therapy we were not able to see any clinical change of the atopic dermatitis. No influence was found on the concentration of IgE in serum and the number of eosinophils in blood. The percentage of T lymphocytes and the Con A-induced suppressor cell activity was not changed. (Received June 18, 1983.)