bluuebunny/crossref_metadata_2025 huggingface dataset:
unity between moral values and social politics in the educational mindset of the Ly – Tran dynasties
Authors: Dung Nguyen Phan Thi Thuy
Published: July 2023

Starting from the attributes and requirements of the history and society of Viet Nam in the 11th to 13th century, which was to build an independent, united, and mighty nation of Dai Viet culture; the request for the unity power of the whole country to fight against the brutal invasion of Nguyen - Mong invaders; along with the inheritance, fusion, and development of the humanity of Confucius, Buddhism, and Taoism based on the spiritual humanity values of Viet Nam, the mindset in the Ly - Tran dynasties era was created and developed, in which the core was the unity between moral values and social politics. This article focuses on discussing the unity between moral values and social politics in the education mindset of The Ly - Tran dynasties era, which is manifested in the purpose and content of the examination system, the close-knit-to-people mindset and laws, and ideology among Dai Viet society at that time.
Examining Government Support for Disability Sports Development
Authors: Kasiyanto Teguh
Published: July 2023

Even though there have been many scientific articles that discuss people with disabilities in Indonesia, studies on government support for the development of special sports for people with disabilities are still few. I will provide an overview of government support for people with disabilities in Indonesia in general and then focus on government support for the development of disability-specific sports. The method in the preparation of this article is a qualitative research method with a thematic study approach with the main subject of literature on policies on documents containing disability in Indonesia. To focus the study of the document, I take Jember Regency as the smallest scope of the source of the document. After that, I looked for articles that regulate sports for people with disabilities. This article will divide the discussion into several sub-themes according to the support provided by the government and the support that still needs to be optimized. Government support is meant to support the development of sports, accessible facilities and infrastructure as well as funding support. This article seeks to provide input on the development of special sports for persons with disabilities in Indonesia.
Progress in Reducing Indoor Tobacco Smoke Pollution Toward the Establishment of Kabupaten/Kota Layak Anak: Evidence From the 2012 and 2017 Indonesia Demographic and Health Surveys
Authors: Puspitasari Mardiana Dwi , Arifa Riza Fatma
Published: July 2023

In 2017, only about 26.68 percent of Indonesian households were smoke-free. Previous research established a relationship between the health of children under five and indoor tobacco smoke pollution. According to Presidential Regulation 25 of 2021, some indicators that should be met for establishing a child-friendly city/ regency (KLA) are the child's rights to health and family environment. Data from the Indonesia Demographic and Health Surveys (IDHS) 2012 and 2017 assessed progress toward smoke-free homes by evaluating the interaction between child age and indoor tobacco smoking at the urban-rural area and regional levels. T-test analysis was used to determine the statistical significance. Findings revealed a higher prevalence of indoor tobacco smoking in rural areas. Over time, the prevalence of indoor tobacco smoking in Indonesian rural areas decreased by 0.84 percent. There was no significant reduction in Kalimantan, Nusa Tenggara, or Maluku-Papua. Furthermore, Sulawesi experienced a significant increase of approximately 4.54 percent. From 2012 to 2017, the prevalence of indoor tobacco smoking was higher in households with children under five, home crowding, poor households, and households with a low education household head. Therefore, interventions should focus on rural areas. City/regency governments in Sulawesi, Kalimantan, Nusa Tenggara, and Maluku-Papua should be more concerned about indoor tobacco smoke pollution. Raising family awareness about the dangers of indoor tobacco smoke pollution could be targeted at households with children under the age of five, overcrowded households, low-income households, and households with a low-education household head.
‘Slow togethering’ as a tool for dialogic development amongst dance dramaturgs
Authors: Laurence Miranda , Živkovič Kranj Sara
Published: July 2023

Thisarticle is an experiment in ‘slow togethering’ between two dance dramaturgs. Itinvestigates dance dramaturgy practice beyond the making of a creative product,in which dialogue aboutpracticeoccurs simultaneously with dialogue aspractice.Thus, the authors propose this article itself as practice research.Weunderstand ‘slow togethering’ as a form of dialogue over time: the articlepresents a series of exchanges by the authors which were written over a periodof one month. Alongside, there is a commentary reflecting on these texts andthe overall process.Withthis format, the authors aim to disrupt the conventions of linear andsequential thinking, offering an opportunity for the reader to exploredifferent ways of encountering the narratives of the article.In this vein,the authors suggest the reader as a dialogue partner in their own right,acknowledging that a reader’s dialogic response resides in a space and timebeyond that of the article.
Manual técnico de apicultura: abeja (Apis mellifera)
Authors: Martínez Sarmiento Rodrigo Alfredo , Ortega Flórez Nelly Carolina , Maldonado Quintero William Dayam , Rodrigo Efrén Vásquez Romero
Published: July 2023

La apicultura es un sistema competitivo, equitativo y sostenible por el bajo uso de insumos e impacto ambiental, y por ser promotor del desarrollo tecnológico, debido a que es generador de empleo, productor de alimentos y mejorador de la calidad de vida de sus trabajadores.
Oral Nano-Delivery Systems for Colon-Targeted Drug Delivery of Traditional Chinese Medicine in Ulcerative Colitis
Authors: Javed Ansari Mohammad , Hadi Suhad J. , H. Kzar Hamzah , Al-Gazally Moaed E. , Ahmed Hamza Thulfeqar , Khudair Hasan Mohammed , Baqir Al-Dhalimy Aiman Mohammed , Akhavan‐Sigari Reza
Published: July 2023

Ulcerative colitis (UC) is a type of inflammatory bowel disease with a high recurrence rate. In this regard, sulfasalazine and immunosuppressive medications are often used for an extended period in clinical practice, but their effectiveness is limited, and they are prone to side effects. Modern research has shown that herbal active ingredients of Traditional Chinese Medicine (TCM), such as polyphenols, alkaloids, quinones, and terpenes, have a promising impact on treating UC via a multi-target mechanism and with low side effects. Poor water solubility and low bioavailability of these agents in the gastrointestinal tract are the most challenging issues in delivering these agents to the target tissues. Researchers have created a variety of oral colon-targeted nano-systems of TCM active ingredients in response to the above formulation issues, which significantly improve the treatment of UC by avoiding gastrointestinal damage, prolonging intestinal retention, and achieving controlled drug release at the lesion site. In order to provide ideas for the oral-targeted treatment of UC with active ingredients from TCM, the research progress of an oral colon-targeted nano-system for the treatment of UC is reviewed in the current study, as well as the research progress of an oral colon-targeted nano-system for the treatment of UC.

Keywords: Medicine, Chinese Traditional, Colitis, Ulcerative, Nanoparticle Drug Delivery System.
Coordination compounds of carbonyl oxygen polychelate ligand; synthesis, physicochemical characterization and biological evaluation
Authors: Abaas Duaa S. , J. Al-Jeboori Mohamad
Published: July 2023

The work covers the formation of the bisaldehyde ligand 2,2'-[ethane-1,2diylbis(oxy)] dibenzaldehyde (M) and its metal complexes. The synthesis of M was achieved via two steps in which two equivalents of the salicylaldehyde were reacted with KOH in an ethanolic medium. Subsequently, the resulting compound dissolved in DMF and one equivalent of 1,2-dibromoethane was added. Adding an ethanolic solution of metal chloride of a range of metal ions to the ligand in a 1:1 (M:L) mole ratio resulted in preparing a new five monomeric complexes. The entity of the isolated structure for the prepared compounds was confirmed using physicochemical methods (FT-IR, electronic spectroscopy, mass and 1H, 13C-NMR spectra, elemental microanalysis, magnetic susceptibility and molar conductance). The characterization data indicated the isolation of six and four-coordinate monomeric complexes with the general formula; [Cr(M)(Cl)2(H2O)2]Cl, [M(M)(Cl)2].H2O (where M= Fe(II), Co(II) and Cu(II)) and [Ni(M)]Cl2.H2O. The anti-microbiological activity of the title compounds (ligand and complexes) was tested against various bacterial and fungal microorganisms. The acquired data revealed that the metal complexes became potentially more active than the M.

Keywords: Bisaldehyde ligand; Novel monomeric metal complexes; Structural study; Antimicrobial activity.
Evaluación de la expresion genetica de Linalool en genotipos de cacao nacional altamente homocigoticos proveniente de las principales zonas cacaoteras tradicionales del Ecuador
Authors: Morillo Eduardo , Buitron Johana , Quiroz-Vera James
Published: July 2023

Ecuador es reconocido a nivel internacional como el principal productor de cacao fino tipo Nacional o sabor “Arriba”. Con la secuenciación del genoma del cacao se identificaron genes que regulan la producción de monoterpenos, entre ellos el gen LIS que codifica a la enzima linalool sintasa, y cataliza la síntesis de linalool que caracteriza al cacao Nacional. El objetivo del presente estudio fue evaluar la expresión del gen LIS en un grupo de clones altamente homocigóticos de una colección de cacaos centenarios (CCNC) mediante qPCR. Para el estudio se obtuvieron almendras de mazorcas autofecundadas de siete accesiones CCNC y tres clones comerciales: EET103 (Tipo Nacional), y dos clones no Nacionales (CCN51 e ICS95-Trinitario). Para cada clon se muestrearon almendras a las 20 (M1) y 22 (M2) semanas de autofecundación y 22 semanas más 24 horas de microfermentación (M3), obteniéndose en total 30 muestras para el análisis (tres momentos por genotipo). El ARN para el analisis de expresión se extrajo a partir de un pool de 10 almendras por muestra. El ARN obtenido se purificó y normalizó para la amplificación de dos genes: el gen SAND usado como gen de referencia y el gen LIS. Para cada muestra se corrieron tres réplicas técnicas por gen. La cuantificación de la expresión relativa se realizó mediante el método ΔΔCt. A partir del análisis se determinó que en los tres momentos analizados (M1, M2 y M3), la expresión del gen LIS varió entre las accesiones CCNC respecto a los calibradores ICS95 y CCN51. El clon comercial EET-103 y accesiones CCNC mostraron una mayor expresión en M2 y M3; la accessión CCNC-210M, altamente homocigótica, registró la mayor expresión del gen LIS en M3 y el clon comercial EET-103 en M2. Los resultados obtenidos son útiles para el mejoramiento genético del cacao Nacional en INIAP y una apropiada utilización y valoración de los recursos genéticos locales.

Palabras Claves: qPCR, gen LIS, ΔΔCt, sabor Arriba
Assessing the Readability of Online Patient Education Materials in Obstetrics and Gynecology Using Traditional Measures: Comparative Analysis and Limitations
Authors: Nattam Anunita , Vithala Tripura , Wu Tzu-Chun , Bindhu Shwetha , Bond Gregory , Liu Hexuan , Thompson Amy , Wu Danny T Y
Published: July 2023

Background

Patient education materials (PEMs) can be vital sources of information for the general population. However, despite American Medical Association (AMA) and National Institutes of Health (NIH) recommendations to make PEMs easier to read for patients with low health literacy, they often do not adhere to these recommendations. The readability of online PEMs in the obstetrics and gynecology (OB/GYN) field, in particular, has not been thoroughly investigated.

Objective

The study sampled online OB/GYN PEMs and aimed to examine (1) agreeability across traditional readability measures (TRMs), (2) adherence of online PEMs to AMA and NIH recommendations, and (3) whether the readability level of online PEMs varied by web-based source and medical topic. This study is not a scoping review, rather, it focused on scoring the readability of OB/GYN PEMs using the traditional measures to add empirical evidence to the literature.

Methods

A total of 1576 online OB/GYN PEMs were collected via 3 major search engines. In total 93 were excluded due to shorter content (less than 100 words), yielding 1483 PEMs for analysis. Each PEM was scored by 4 TRMs, including Flesch-Kincaid grade level, Gunning fog index, Simple Measure of Gobbledygook, and the Dale-Chall. The PEMs were categorized based on publication source and medical topic by 2 research team members. The readability scores of the categories were compared statistically.

Results

Results indicated that the 4 TRMs did not agree with each other, leading to the use of an averaged readability (composite) score for comparison. The composite scores across all online PEMs were not normally distributed and had a median at the 11th grade. Governmental PEMs were the easiest to read amongst source categorizations and PEMs about menstruation were the most difficult to read. However, the differences in the readability scores among the sources and the topics were small.

Conclusions

This study found that online OB/GYN PEMs did not meet the AMA and NIH readability recommendations and would be difficult to read and comprehend for patients with low health literacy. Both findings connected well to the literature. This study highlights the need to improve the readability of OB/GYN PEMs to help patients make informed decisions. Research has been done to create more sophisticated readability measures for medical and health documents. Once validated, these tools need to be used by web-based content creators of health education materials.
The Relevance of Sexual Health Websites for African American Adolescents (Preprint)
Authors: Barnard Ke'ala , Catania Joseph A. , Dolcini M M , Schuyler Ashley , Dyer Jr Gerald B.
Published: July 2023

BACKGROUND

School-based sex education (SE) can reduce adolescent sexual health problems. However, only 49-55% of adolescents receive SE that meets national standards. African American youth (AAY), particularly males, are less likely to receive SE. AAY evidence a high prevalence of STIs/teen pregnancy. Internet-based SE offers a supplemental option. We examined the quality and relevance to AAY of internet-based SE.

OBJECTIVE

To examine the relevance and quality of sexual health websites, particularly to African American adolescents

METHODS

We evaluated 37 sites (U.S., English, January-February 2022) meeting specific inclusion/exclusion criteria. Two evaluation indices for Relevance and General Quality were developed. Relevance criteria (to AAY) included content: a) with images of African Americans, b) specific to African American audiences, and c) addressing disparities in AAY sexual health. General Quality was assessed using an adaptation of Buhi et al.’s (2010) measures (e.g., author’s credentials, references). Relevance and General Quality criteria were scored to produce separate index scores (Relevance = 0 – 3; General Quality = 0 – 7; high scores = greater relevance, higher quality).

RESULTS

A majority (57%) of sites met all Relevance criteria; 19% achieved high General Quality scores (6-7). Relevance and General Quality were significantly correlated (r = .28, P < .05). Only 4 sites (11%) had the highest rankings on both indices (WebMd, Healthline, Harvard Health & Very Well Health).

CONCLUSIONS

A substantial minority (43%) of SE websites have low relevance to AAY and are of modest-poor quality (41%). Sites ranking high on both indices typically had more professional involvement and oversight. We recommend a similar analytic approach be applied to studying SE website relevance for LGBTQ+, other ethnic/racial, and gender-expansive sub-populations.
Efek Pemberian Metformin dan Metformin+Glimepiride terhadap Kadar HbA1c pada Pasien Diabetes Mellitus Tipe 2
Authors: Apriliany Fitri , Cholisah Elis , Erlianti Karina
Published: July 2023

Diabetes is a chronic metabolic disease and management of DM begins with a helthy lifestyle with early administration of antidiabetic drug. Metformin is the first line therapy in the management of DM. Combination therapy is given if blood sugar level and HbA1c level cannot be controlled with single therapy. This study aimed to determine the effect of giving metformin and metformin+glimepiride on HbA1c levels in DM2 patients. The inclusion criteria were patients DM, received oral antidiabetic at least 6 months, completed medical record, and can speak Indonesia. Exclusion criteria included DM patients receiving insulin therapy, TB patients, patients with mental disorders, and pregnant/breastfeeding women. Sociodemographic data, description of prescribing patterns, and achievement of HbA1c levels were described descriptively. Data analysis using the Wilcoxon test. Respondents in this study were 69 patients,  dominated by women (71%). The types of therapy used were metformin (59.4%) and metformin+glimepiride (40.6%). Achievement of metformin + glimepiride HbA1c levels (67.9%), metformin (48.8%). The difference in decreasing HbA1c levels with metformin (-0.31%±0.38 mg/dL) and metformin+glimepiride -0.33%±0.54 mg/dL (p = 0.000). The results of the analysis showed that there is a significant effect of metformin alone on decreasing HbA1c levels and the addition of glimepiride (metformin + glimepiride) on reducing HbA1c levels in diabetes cannot be controlled with metformin. The implication of this study is as input for comprehensive management guidelines that can be used in an effort to reduce the prevalence of DM. Good management is needed to achieve therapeutic outcomes.
Knowledge, Attitude, and Medicine Taking Behavior of Lymphatic Filariasis Patients in Two Villages in West Kotawaringin Regency
Authors: Suryatinah Yuniarti , Rahayu Nita
Published: July 2023

Kotawaringin Barat Regency carried out the lymphatic filariasis mass drug administration (LF MDA) and in 2016 it was declared to have passed the 3rd transmission assessment survey (TAS). One success factor of 3rd TAS is behavior of adherence to taking preventive drugs from community participated. The purpose of this article is to analyze the relationship between knowledge and attitude of adherence to taking filariasis prevention drugs in two villages in West Kotawaringin Regency. The study was conducted in 2017 using an observational design with a cross-sectional approach. The samples used were 273 people ≥ 15 years. The instrument is a questionnaire of knowledge, attitudes and behavior related to LF MDA. Respondent characteristics and knowledge description were analyzed descriptively. Then chi square test was carried out to determine the relationship between gender, age, education, knowledge and attitudes towards drug-taking behavior. The results of the study found that the percentage of respondents in West Kotawaringin Regency who had good knowledge is 58.2%, the number of respondents with good attitudes is 66.7% and 89.4% of them behaved obediently in taking preventive drugs filariasis. Gender (p = 0.794), age (p = 0.372), education (p = 0.263), knowledge (p = 0.536) and attitude (p = 0.765) were not significantly related adherence behavior to taking filariasis prevention drugs. The conclusion of the study is that there are other factors other than gender, age, education, knowledge and attitude that can affect the behavior of adherence to taking filariasis prevention drugs in two villages in West Kotawaringin Regency.
Evaluation of the Use of Antidiabetic Drugs in Patients of Back-Referral Program at the Demak District Pharmacy
Authors: Pitasari Nawang Wulan Nago , Andayani Tri Murti , Wijayanti Tri
Published: July 2023

Drugs are one of the important components of the Back-Referral Program (BRP), so the guarantee of the availability of BRP drugs in pharmacies is a factor in the success of BRP implementation. The purpose of this study was to determine the consumption of antidiabetic drugs using ATC/DDD and 90% DU methods, analyze the cost of consuming antidiabetic drugs, and determine the suitability of antidiabetic drugs with the National Formulary. This study was an observational study with a cross-sectional design and retrospective data collection. The study was conducted at 6 BRP pharmacies, namely Pharmacy A, Pharmacy B, Pharmacy C, Pharmacy D, Pharmacy E, and Pharmacy F in the area of Demak Regency. The antidiabetic drug consumption data was obtained from BRP patient prescriptions from July 2020 to June 2021. The cost data were obtained based on prices in the JKN drug e-catalog system at BRP pharmacies in the area of Demak Regency. In analyzing the data, the researcher calculated DU at 90%, the cost of drugs included in the DU segment at 90%, and the suitability of drugs with the National Formulary. The results showed that the highest consumption of antidiabetic drugs in Back-Referral Program (BRP) pharmacies in the area of Demak Regency was glimepiride (54.72%) and metformin (31.01%). The highest cost of consuming antidiabetic drugs per DDD was insulin (Rp.17,639.73), the lowest cost was glimepiride (Rp.65.35), the total cost of antidiabetic drugs was Rp.53,509,090 and an incompatible drug with National Formulary was pioglitazone. In general, the highest consumption of antidiabetic drugs in Back-Referral Program (BRP) 6th pharmacies in the area of Demak Regency, which was included in the DU segment 90%, were glimepiride, metformin and the suitability of drugs with the National Formulary has not reached 100%.
Virgin Coconut Oil (VCO) Attenuates Hepatotoxicity Induced by Cigarette Smoke in Rats
Authors: T. Lilis , Simorangkir Saharnauli Janna verawaty , Marpaung Okto P.E.
Published: July 2023

Researchers have connected the antioxidants in virgin coconut oil (VCO) to the growing health benefits; however, little is known about the hepatoprotective and antioxidant properties of VCO against oxidative stress and liver damage brought on by smoking cigarettes. The research examined the hepatoprotective and antioxidant properties of VCO against oxidative stress and liver damage. Male Wistar rats were split into 4 groups: Group 1 (the control group) was fed rat pellets; Group 2 (the control positive group) was fed the basic diet and exposed to cigarette smoke; Group 3 was fed the basic diet and 0,45 ml VCO; Group 4 was provided the basic diet and 0,9 ml VCO. Serum liver biomarker (SGPT and SGOT) assays were performed after 28 days of therapy. When compared to the control group, exposure to cigarette smoke caused a substantial increase in blood liver enzymes. Treatment with VCO significantly prevented an increase of SGPT and SGOT levels compared to control positive group P2. This study demonstrated that inhaling cigarette smoke damages the liver and established the hepatoprotective properties of VCO against cigarette smoke-induced liver damage via reducing oxidative stress.
Physical Stability of Binahong Leaf Extract (Anredera cordifolia (Ten.) Steenis) with Hydroxypropyl Methylcellulose and Hydroxyethyl Cellulose Gelling Agents
Authors: Sari Siska Purnama , Zulkarnain Abdul Karim
Published: July 2023

Second-degree burns have the highest prevalence and often occur in the household environment. The healing process can be accelerated by traditional medicine. One of the many plants known to have wound-healing abilities is the Binahong plant (Anredera cordifolia (Ten.) Steenis). The gel preparation is chosen because of the many benefits it can provide. The gelling agents used were Hydroxypropyl Methyl Cellulose and Hydroxyethyl Cellulose. The combination of these gelling agents was chosen because both agents are capable of producing gel preparations with good stability during storage. Therefore, the optimization was carried out to obtain the optimum formula that met the requirements. The observed responses were organoleptic, pH, spreadability, adhesion, viscosity, and homogeneity. The data obtained was optimized with the Simplex Lattice Design program in Design Expert software version 13.0.0. The results of the verification test were compared for their significance with the T-test with a 95% confidence level. The optimum gel stability of Binahong leaves (Anredera cordifolia (Ten.) Steenis) was tested using one-way ANOVA and post hoc. The results showed that the optimum formula for Binahong leaf extract gel (Anredera cordifolia (Ten.) Steenis) was obtained with a composition ratio of 0.5% HPMC and 4.5% HEC. The verification results obtained valid values for pH response, viscosity, and spreadability according to SLD predictions. The optimum formula for Binahong leaf extract gel (Anredera cordifolia (Ten.) Steenis) was stable during the cycling test.
Analysis of the Impact of Marijuana Legalization on Smoking among Adolescents before the Age of 13
Authors: Liu Wanzheng
Published: July 2023

Adolescent smoking, with its detrimental effects on working memory and increased likelihood of heavy smoking when initiated at a younger age, this paper examines whether marijuana decriminalization policies affect adolescents’ likelihood of smoking before age 13. This paper mainly uses the stack Difference In Difference method to judge the relationship between the two and further proves the time-invariant through the stack event study method. Moreover, the CS model (double robust) was used to observe the different effects of different periods. This study attempts to discover the causes of early adolescent smoking and, to some extent, verify the possibility that cigarettes and marijuana are complementary commodities. This study found that marijuana decriminalization policies increased adolescents’ likelihood of smoking before age 13 by about 0.173%. At the same time, the time study shows that the policy may have a lag effect.
EVALUATION OF UNDERSTANDING AND ATTITUDE TOWARDS THE CONCEPT AND IMPLEMENTATION OF SUSTAINABLE DEVELOPMENT
Authors: Prodović Milojković Biljana
Published: July 2023

The paper focuses on the development of the concept of education for sustainable development in the regions where the research is conducted; with the presentation of respondents' opinions for all three observed areas. The author's contribution to this work is reflected in pointing out the basic factors and essential problems that arise when reforming the educational system in order to apply the concept of education for sustainable development. The paper offers solutions to these problems, providing established guidelines on how to reform the education system. In this case, it is about the perception of students of three regional centers - Niš and Kosovska Mitrovica in Serbia, and East Sarajevo - Pala in Bosnia and Herzegovina. The results of our research show that a very small number of students are familiar with the emergence of the idea of OR, which confirms the fact that awareness and especially knowledge of citizens about OR, both at the level of the EU and especially at the level of Serbia, is far from desirable and necessary. The results of the research can be useful for decision makers who participate in the creation of the educational system; and they would be particularly significant for the reform of the education system in Serbia, where education for sustainable development is still viewed as a theoretical rather than a practical issue.
Microstrip Patch Antenna for Modern Communication Applications
Authors: Ramacharya Srinivas
Published: July 2023

Abstract: In this communication the overview of Microstrip Patch Antenna for modern Communication applications. This paper illustrates the basic structure of the microstrip antenna. The excitation methods are presented. The simulation of these antennas using different software’s is discussed. The applications of microstrip antennas with its modifications are presented.
A Systematic Review Paper on : Need of Smart Home Architecture for Old People
Authors: Bhadouria Aashi Singh , Bhadouria Ishan Singh , Patel Vanshika , Upasani Akshat
Published: July 2023

Abstract: In order to allow people to age in place and maintain their independence, this study evaluates existing approaches to integrating cutting-edge technology into the home remodelling process. Articles that acted as systematic reviews looked at research from the disciplines of smart technology, ageing studies, and architectural planning. We reviewed databases from similar scientific fields in addition to doing manual searches (e.g., Scopus, Web of Science, Engineer Village, Google Scholar, and Cross Reference). Out of a total of 2594 papers, 33 were analysed to determine what was known about the smart home environment for ageing in place, the process of smart house modification, and the challenges to and solutions for independent living. The findings suggest that older adults might gain from using smart technology and house modifications to increase accessibility and reduce the risk of falls. The notion of the robotic house has emerged as home help technologies for the elderly evolve from manual devices to intelligent ones. When it comes to building and personalising smart homes, universal design is a regular practise. In spite of this, universal design isn't only used for smart homes; it's also a frequent retrofitting requirement for conventional dwellings. Individualization, little disturbance to everyday life, and age-adaptive technology are the major needs for smart home remodelling stages.
Antioxidant and Antibacterial Activity of Boerhavia diffusa against Gram Negative UTI causing Bacteria
Authors: H Haritha K , J Sneha
Published: July 2023

Abstract: Due to the use of Boerhavia diffusa in traditional medicine against kidney diseases and infectious processes, this study evaluated the in vitro antimicrobial potential, phytochemical composition and antioxidant activity of extracts from its stem and leaves. From leaves and stems of Boerhavia diffusa different extracts were obtained (ethanol: BDE , n-butyl alcohol: BDB). The antimicrobial activity was evaluated by the disc diffusion method using different concentrations against bacteria clinically isolated samples from UTI patients. Preliminary phytochemical screening of ethanol extracts of Boerhavia diffusa showed the presence of Flavanoids, Terpenoids, Saponins, absence of alkaloids, Tannins, Phenol, Anthocyanin, Carbohydrates. In the DPPH radical scavenging assay, the result shows as different concentration 12.5μg/mL, 25μg/mL,100μg/mL, 200μg/mL in both plant extracts with percentage of inhibition. These results encourage the identification of active substances which could be used as lead molecules in the development of new antimicrobial drugs for the treatment of UTI causing bacteria.
Quality Management System in High Rise Buildings
Authors: Mangaraj Abhijit , Patra Dhiranjana , Parida Ananya , Bobade Nitin Narayan
Published: July 2023

Abstract: The growing demand for more living space and scarcity of land availability is leading to vertical development of building projects in Indian cities. India is the second-most populated country in the world and so its cities. Growing urban population and shrinking availability of land is pushing for a vertical development of realty projects. While skyscrapers have become a necessity in metros and Tier 1 cities in India, Tier 2 cities are now gradually following the trend with growing population and changing lifestyles. Property and land are becoming costly and scarce where tall buildings pose the best option. Developing vertically through constructed structures can accommodate more people, than developing horizontally, which saves availability of land also. And Quality management in high-rise building construction projects is an essential factor to avoid defects in the end product, which could lead to the need for replacements, faults, accidents or any kind of anomalies that will end up having a negative impact on the final result and the customer's experience
Enhancing Tourism Potential of Ramtek Town, Maharashtra
Authors: Patil Ar. Niharika
Published: July 2023

Abstract: Tourism is acknowledged to be important for development due to its various factots encompassing economic, social, political, environmental, cultural and psychological characteristics . It is also recognized as one of the world’s largest industries, contributing 10% to the global GDP, with enormous potential for further growth. In many countries, especially in the developing countries, tourism has become a major source of foreign exchange earnings emphasizing the need for concentrated and sustained efforts towards its development. . Tourism industry in Maharashtra has a tremendous potential for growth, given the availability of basic infrastructure and the variety of tourist themes offered by various destinations in Maharashtra. Maharashtra has a rich historical and cultural heritage, which has been under-explored by the tourism industry and the government agencies. we are trying to focus one such Pilgrimage Tourist Place “Ramtek” in Maharashtra. Primarily it is a pilgrimage centre also known as kashi of vidarbha for the existence of Ambala lake which is considered as ganga.Ramtek town observes the yatra three times a year during period of Dashahara, Kartik Poornima and shriramnavmi which attracts the people from all-around the region to enjoy the same. The number of pilgrims coming to visit yatra was around one lakh at some time,nowadays reduce in thousands. Ramtek pilgrimage is seen under different religions like Jainism, Hindus and Muslims. The water bodies in the form of lakes, baolis(stepped wells) are the part of rituals. Some of these are also termed as ‘Ganga’, holy water hence deity is placed inside it. Agasthi aashram at ramgiri has got its historical and religious importance in Ramtek.This dissertation is slimly based on to enhance the tourism potential of the ramtek and due to this it could be help in growth of town and also could have job opportunities for the people living in the ramtek town and also we will enhance the existing tourism spots with coordination of religious and leisure tourism
INCREASING ANTIOXIDANT ACTIVITY OF SUPEROXIDE DISMUTASE AND DECREASING MALONDIALDEHYD LEVELS FROM Ethanol Extract of Radish (Raphanus Sativus L.) LEAVES IN SWIMMING MICE
Authors: Khairani Sondang , Sandhiutami Ni Made Dwi , Sari Ika Permata
Published: July 2023

Daun lobak (Raphanus sativus L.) mengandung senyawa flavonoid yang memiliki aktivitas sebagai antioksidan. Penelitian ini bertujuan untuk menguji efek antioksidan ekstrak etanol 70% daun lobak (Raphanus sativus L.) berdasarkan parameter kadar malondialdehid (MDA) dan aktivitas superoksida dismutase (SOD). Mencit dibagi menjadi 6 kelompok yaitu: kelompok kontrol normal, kelompok kontrol negatif, kelompok kontrol positif (vitamin C 2,6 mg/20gBB), dan 3 kelompok dosis ekstrak etanol 70% daun lobak (Raphanus sativus L.) (5,6; 11,2; 22,4 mg/20gBB). Pengukuran kadar MDA dilakukan dengan metode Wills dan pengukuran aktivitas SOD dilakukan dengan metode Adrenochrome Assay. Hasil pengukuran kadar MDA pada kelompok normal, kelompok kontrol negatif, kelompok kontrol negatif, kelompok kontrol positif, kelompok dosis 5,6 mg/20gBB; 11,2 mg/20gBB; 22,4 mg/20gBB secara berturut-turut adalah 2,1617 nmol/mL; 5,3075 nmol/mL; 2,3331 nmol/mL; 4,5583 nmol/mL; 3,5957 nmol/mL; 2,6702 nmol/mL sedangkan untuk hasil pengukuran aktivitas SOD hati mencit adalah 124,2383 U/mL; 65,64 U/mL; 176,7583 U/mL; 106,045 U/mL; 134,34 U/mL; 153,53 U/mL. Kesimpulan hasil yang didapatkan adalah ekstrak etanol 70% daun lobak (Raphanus sativus L.) memiliki potensi antioksidan dengan menurunkan kadar malondialdehid (MDA) dan meningkatkan aktivitas superoksida dismutase (SOD).
Pengkajian Administrasi Resep Anak Di Salah Satu Puskesmas Kabupaten Tangerang
Authors: Saibi Yardi , Suryani Nelly , Pratiwi Shella Desilia
Published: July 2023

Pengkajian resep anak penting untuk dilakukan untuk mencegah terjadinya medication error. Penelitian ini bertujuan untuk melakukan pengkajian resep pasien anak-anak di salah satu puskesmas yang ada di wilayah kabupaten Tangerang. Penelitian ini merupakan penelitian cross sectional deskriptif. Populasi adalah seluruh resep pasien pediatri pada rawat jalan. Sampel yang diambil sebanyak 100 resep secara acak sederhana . Kriteria inklusi yaitu seluruh resep pasien pediatri rawat jalan pada bulan Desember tahun 2018 di unit ruang pelayanan kefarmasian. Kriteria eksklusi yaitu resep pasien pediatri yang tidak dapat terbaca oleh peneliti. Klirens etik penelitian didapatkan dari Komite Etik Penelitian Kesehatan Fakultas Kedokteran Universitas Indonesia. Data diolah dengan menggunakan analisa statistik univariat. Hasil penelitian menunjukkan bahwa aspek kelengkapan administrasi yang sudah lengkap yakni nama pasien, umur dan tanggal penulisan resep (100%). Tiga aspek lainnya yang sama sekali tidak memenuhi kelengkapan yakni jenis kelamin pasien, berat badan pasien serta ruangan/unit asal resep (0%). Dari persyaratan farmasetik, aspek bentuk sediaan dan kekuatan sediaan sama sekali tidak ditemukan pada resep (0%). Sedangkan dosis, jumlah dan aturan pemakaian obat memenuhi syarat kelengkapan. Dapat disimpulkan bahwa pengkajian resep secara administrasi dan farmasetik di puskesmas ini perlu dilakukan sebagai upaya untuk mengevaluasi kelengkapan resep yang sesuai dengan standar pelayanan yang berlaku.
Analisis Pewarna Merah Pada Makanan Jajanan Anak-Anak Yang Dijual Di Sekolah TK dan SD di Wilayah Jakarta Timur
Authors: Fatimah Nisma  , Wijiastuti Wijiastuti , Siska Putri Elfia
Published: July 2023

Warna merah adalah warna yang banyak disenangi anak-anak, sehingga makanan jajanan yang berwarna merah lebih disukai. Pewarna merah yang ditambahkan dalam makanan seharusnya adalah pewarna alami  untuk makanan. Seringkali pewarna pada jajanan anak-anak menggunakan pewarna sintetik yang dilarang penggunaannya untuk makanan seperti pewarna rhodamin B atau pewarna sintetik lain yang dibatasi penggunaannya seperti karmoisin, eritrosin dan Ponceau 4R. Akibat penggunaan zat warna sintetik itu dapat membahayakan kesehatan bahkan dapat menimbulkan kanker dan penyakit berbahaya lainnya. Tujuan penelitian ini  adalah melakukan analisis pewarna yang digunakan pada makanan jajanan anak-anak yang berwarna merah di wilayah Jakarta Timur. Pengambilan sampel penelitian dilakukan di sekolah- sekolah TK dan SD yang ada di Jakarta Timur, diperoleh sampel 173 makanan padat dan 20  minuman yang berwarna merah, sampel dikelompokkan lagi menjadi 90 sampel uji. Analisis pewarna merah dilakukan secara kualitatif dengan metode kromatografi kertas dan spektrofotometer visibel dengan membandingkan nilai Rf sampel uji dengan kromatogram pembanding pada kromatografi dan membandingkan absorbansi dan panjang gelombang maksimum pada spektrofotometer. Hasil yang diperoleh adalah pewarna merah yang terkandung pada makanan jajanan anak TK dan SD di wilayah Jakarta Timur adalah Karmoisin 13, Ponceau 4R 9, Eritrosin 2 dan Rhodamin 3 sampel.
Outcome Klinik Berdasarkan Pemilihan Jenis Insulin pada Pasien Diabetes Mellitus Tipe 2
Authors: Yuliasari Ida , Anggriani Yusi , Utami R Hesty
Published: July 2023

Diabetes Mellitus ( DM ) merupakan penyakit tidak menular yang meningkat prevalensinya setiap tahun di Indonesia. Salah satu tatalaksana terapi DM adalah terapi farmakologi menggunakan insulin. Insulin yang beredar di Indonesia terdiri dari insulin manusia dan insulin analog. Tujuan dari penelitian ini adalah untuk mengetahui pola penggunaan insulin dan outcome klinik berdasarkan pola penggunaan insulin pada pasien rawat jalan dengan diagnosa DM tipe 2. Penelitian dilakukan secara longitudinal time series melalui pengambilan data retrospektif di Rekam Medis dan Farmasi yang meliputi data pasien, data obat dan data pemeriksaan laboratorium. Jumlah sampel sebanyak 86 pasien yang terdiri dari 28 pasien pengguna insulin manusia dan 56 sampel pasien pengguna insulin analog. Outcome klinik dihitung dari nilai GDP, GDPP dan HbA1C berdasarkan pemilihan jenis insulin menggunakan Kruskal Wallis dan Mann Whitney. Hasil penelitian menunjukkan bahwa tidak ditemukan penggunaan insulin manusia pada pasien DM tipe 2 rawat jalan tahun 2016 dan 2017. Pada outcome klinik ditemukan bahwa tidak ada perbedaan outcome klinik dari penggunaan insulin analog dan insulin manusia pada pasien DM tipe 2 rawat jalan pada nilai GDP dan HbA1C, sedangkan pada nilai GDPP terdapat perbedaan. Kesimpulan pada penelitian ini adalah tidak terdapat perbedaan outcome klinik berdasarkan pemilihan jenis insulin pada nilai GDP dan HbA1C sedangkan pada nilai GDPP terdapat perbedaan.
SISTEM PENGHANTARAN OBAT KOAMORF : PREPARASI DAN PEMILIHAN KOFORMER
Authors: Hakim Muhammad Lukman Nur , Rusdiana Taofik
Published: July 2023

Saat ini berbagai macam metode dan teknik untuk memperbaiki sifat fisik seperti kelarutan dan disolusi dari obat-obat golongan BCS kelas II dan IV telah banyak dikaji, diantaranya sistem penghantaran obat koamorf. Sistem penghantaran obat koamorf (co-amorphous drug delivery system) adalah sistem penghantaran obat dengan kombinasi dari dua atau lebih komponen dengan bobot molekul yang rendah dan membentuk sistem fase tunggal homogen. Tujuan review ini adalah untuk mengkaji aspek preparasi dan pemilihan co-former dalam menghasilkan sistem koamorf yang baik. Parameter yang berpengaruh dalam pemilihan co-former yang baik adalah sifat fisikokimia zat aktif serta eksipien dan tendensi kristalisasi materi. Metode pada review ini yaitu studi literatur dengan hasil berupa teknik preparasi, pemilihan zat aktif, kombinasi dengan eksipien, sampai dengan metode serta mekanisme yang diperoleh harus diperhatikan dalam formulasi.
PENGARUH KOMBINASI PEMANIS ASPARTAM - XYLITOL TERHADAP SIFAT FISIK TABLET HISAP EKSTRAK BUAH KAPULAGA
Authors: Vidya Ningrum Frisca , Mulya Lestari Pramulani , Nugrahaeni Fitria
Published: July 2023

Ekstrak kental buah kapulaga telah dimanfaatkan secara tradisional sebagai antikaries karena memiliki kandungan sineol, untuk memudahkan penggunaannya maka ekstrak dibuat dalam sediaan tablet hisap dengan kombinasi pemanis aspartam - xylitol. Penelitian ini bertujuan untuk mengetahui pengaruh variasi kombinasi pemanis aspartam - xylitol terhadap sifat fisik tablet hisap. Tablet hisap dibuat dalam 5 formula berdasarkan kombinasi pemanis aspartam - xylitol yaitu F1 (3%:6%), F2 (3%:9%), F3 (3%:12%), F4 (3%:15%), F5 (3%:18%). Pembuatan tablet hisap ini menggunakan metode granulasi basah. Sifat fisik tablet yang diuji meliputi organoleptis, kekerasan, kerapuhan, waktu larut serta tanggap rasa kemudian dibandingkan dengan pustaka yang diacu. Hasil evaluasi tablet pada semua formula memenuhi persyaratan. Hasil analisa One Way ANOVA data kekerasan, kerapuhan serta waktu larut menunjukkan adanya perbedaan yang bermakna pada masing-masing formula. Hasil analisa Chi Square menunjukkan ada hubungan yang signifikan antar formula dengan rasa tablet yang dihasilkan, sehingga dapat disimpulkan bahwa variasi kombinasi pemanis aspartam - xylitol berpengaruh terhadap sifat fisik tablet dalam meningkatkan kekerasan, menurunkan kerapuhan, memperlama waktu larut serta meningkatkan kesukaan terhadap rasa dari tablet hisap.
DETEKSI CEMARAN TIKUS PADA SAMPEL SOSIS DENGAN REAL TIME PCR
Authors: Sunaryo Hadi , Nikmatullah Nurul Azmah , Mufidah Samiratul
Published: July 2023

Makanan merupakan kebutuhan pokok manusia yang pengolahannya perlu diperhatikan dengan baik dan benar agar bermanfaat bagi tubuh. Akan tetapi belakangan ini tidak jarang masyarakat menemukan makanan yang tidak lagi terjamin keamanannya terkait dengan budaya dan agama. Indonesia merupakan salah satu negara yang memiliki jumlah penduduk muslim mencapai 87,2%. Dalam ajaran Islam daging tikus merupakan bahan pangan yang tidak halal atau tidak diperbolehkan untuk dikonsumsi, sehingga kehadirannya dalam suatu olahan makanan merupakan isu yang sangat penting. Oleh karena itu, penelitian ini bertujuan untuk mengidentifikasi cemaran Tikus pada sampel sosis menggunakan metode Real Time Polymerase Chain Reaction (RT-PCR). Metode ini dapat memonitor progres reaksi identifikasi adanya DNA tikus dengan lebih spesifik tanpa perlu melakukan analisis dengan elektroforesis gel. Pengumpulan sampel dilakukan dengan metode accessible population yaitu populasi yang dapat dijangkau oleh peneliti. Hasil yang didapatkan dalam 30 sampel sosis ditemukan 1 diantaranya mengandung DNA Tikus dengan nilai Ct 36,16
Estratégias de prevenção do suicídio por intoxicação exógena medicamentosa entre mulheres no município de Uberlândia - Minas Gerais
Authors: Pinheiro Paes Leme Alissa , Rosa Pascoal Jair , Laura Silva Neres Agnes , Vilges de Oliveira Stefan , M. Okada Leticia
Published: July 2023

Introdução: Terapias medicamentosas são fundamentais para o manejo de diversas condições na saúde. Todavia, seu uso irracional é potencialmente danoso, especialmente no contexto de intoxicação exógena com motivação suicida. Nesse sentido, este trabalho visa discutir esses casos para propor uma intervenção que contribua para mitigar este agravo da saúde, principalmente entre mulheres (epidemiologicamente predispostas ao suicídio por esta via). Materiais e Métodos: Trata-se de um estudo observacional descritivo dos índices de tentativa de suicídio por intoxicação medicamentosa na população feminina do município de Uberlândia (MG), de 2017 a 2021. Os dados foram extraídos do SINAN e do IBGE, e as variáveis avaliadas foram: ano de notificação, sexo, faixa etária, raça, circunstância de ingestão do agente tóxico, tipo de exposição, classificação final, critérios de confirmação e evolução do caso. Os dados foram compilados no tabulador do Tabnet do DATASUS e no Excel. Realizou-se o cálculo de indicadores de saúde e uma revisão sistematizada de literatura nas bases de dados Periódicos CAPES e SciELO, selecionando 6 artigos publicados entre 2017 e julho de 2022 para elaborar a intervenção. Resultados: Foram notificados 1064 casos de intoxicação exógena medicamentosa no sexo feminino (72,58%), sendo 46,33% na faixa etária de 20 a 39 anos. 83,17% dessas notificações foram feitas devido a tentativas de suicídio entre mulheres no período descrito. Discussão: Em outros municípios, as tentativas de suicídio entre mulheres jovens ocorrem predominantemente por intoxicação exógena medicamentosa, assim como em Uberlândia, enquanto que, entre homens, o suicídio costuma ocorrer por vias mais letais. Conclusões: Como estratégia de prevenção, faz-se necessário otimizar os dispositivos legais de restrição de medicamentos, fortalecer redes de serviços de saúde e capacitar os profissionais de saúde para identificar fatores de risco, além de estimular a notificação adequada dos casos para elaborar políticas públicas de saúde mais efetivas.