bluuebunny/crossref_metadata_2025 huggingface dataset:
Evidence-Based Exploration as the Ground for Heritage-Led Pathways in Insular Territories: Case Study Greek Islands
Authors: Koutsi Dionisia , Lagarias Apostolos , Stratigea Anastasia
Published: September 2022

Global key drivers—e.g., climate change, COVID-19 outbreak—have initiated critical debates as to the sustainable future pathways of many regions around the globe. Among these fall islands, as distinct types of regions that are marked by insularity drawbacks and a mono-sectoral economic profile, grounded in mass tourism. Having as a case study area all Greek islands, this work addresses: sustainability concerns that are due to the mass tourism repercussions in these heritage-endowed territories; and efforts undertaken by the Greek insular municipalities to deploy, in a collaborative manner, strategic cultural tourism plans in support of the transition from a resource-intensive mass tourism pattern to natural and cultural heritage-led future developmental trails. Towards this end, a two-stream methodological approach is used that relies on: quantitative, spatially-defined data elaboration/interpretation and visualization, highlighting the dynamics of tourism development in island territories; and qualitative data on issues related to the aforementioned plans from all insular municipalities, gathered through a web-based questionnaire. Research results unveil the unsustainable spatial and developmental patterns of Greek insular contexts and the shortage of mainstream planning expertise for collaboratively establishing attractive cultural-tourism ensembles. These factors restrain sustainability achievements and the repositioning of Greek islands in the global scenery as authentic heritage-led destinations.
Regional Differences in Metabolic Risk in the Elderly in Korea
Authors: Kim Ji-Myung , Bae Yun-Jung
Published: September 2022

Lifestyle and dietary differences in urban and rural environments have different impacts on elderly health. We aimed to evaluate the nutritional intakes and metabolic risks in the urban and rural elderly. We analyzed 3018 elderly individuals (1358 men, 1660 women) who were aged 65 years and older using the Korea National Health and Nutrition Examination Survey data (2013–2016). Anthropometric data, blood pressure, and blood profiles were collected using health examinations. Daily dietary intakes were analyzed by the 24-h dietary recall method. Rural elderly women had significantly higher triglycerides (TG) levels and lower high-density lipoprotein (HDL)-cholesterol levels than urban elderly women (p = 0.014, p = 0.005). The rural elderly had higher carbohydrate intake and percentage of carbohydrate energy intake and lower intakes of fat, vitamin A, vitamin B2, and vitamin C and percentage of fat energy intake than the urban elderly for both men and women (p < 0.05). The odds of high TG and low HDL-cholesterol were 1.66 (95% confidence interval [CI] 1.23–2.23) and 1.33 (95% CI 1.01–1.77), respectively, in elderly women living in rural areas compared to their urban counterparts, after adjusting for confounding factors. Therefore, nutritional intervention might be needed to improve the nutritional status of the elderly in rural areas and to manage low HDL-cholesterol in rural women.
Alcohol Health Warning Labels: A Rapid Review with Action Recommendations
Authors: Giesbrecht Norman , Reisdorfer Emilene , Rios Isabelle
Published: September 2022

A rapid review of research on health warning labels located on alcohol containers (AWLs) was conducted. Using five search engines (Embase, Medline, Pubmed, Scopus, Psyinfo), 2975 non-duplicate citations were identified between the inception date of the search engine and April 2021. Of those, 382 articles were examined and retrieved. We selected 122 research papers for analysis and narrative information extraction, focusing on population foci, study design, and main outcomes. Research included public opinion studies, surveys of post-AWL implementation, on-line and in-person experiments and real-world quasi-experiments. Many studies focused on the effects of the 1989 United States Alcoholic Beverage Labeling Act on perceptions, intentions and behavior. Others focused on Australia, Canada, the United Kingdom, England or Scotland, Italy and France. There was substantial variation in the design of the studies, ranging from small-scale focus groups to on-line surveys with large samples. Over time, evidence has been emerging on label design components, such as large size, combination of text and image, and specific health messaging, that is likely to have some desired impact on knowledge, awareness of risk and even the drinking behavior of those who see the AWLs. This body of evidence provides guidance to policy-makers, and national and regional authorities, and recommendations are offered for discussion and consideration.
Real World—Big Data Analytics in Healthcare
Authors: Piovani Daniele , Bonovas Stefanos
Published: September 2022

The term Big Data is used to describe extremely large datasets that are complex, multi-dimensional, unstructured, and heterogeneous and that are accumulating rapidly and may be analyzed with appropriate informatic and statistical methodologies to reveal patterns, trends, and associations [...]
Liposomes Containing Amaranth Unsaponifiable Matter and Soybean Lunasin Suppress ROS Production in Fibroblasts and Reduced Interleukin Production in Macrophages
Authors: Dávila-Ortiz Gloria , Castañeda-Reyes Erick Damian , Juárez-Palomo Carlos Ignacio , Perea-Flores María de Jesús , Pérez-Pastén-Borja Ricardo , Márquez-Flores Yazmín Karina , González de Mejía Elvira
Published: September 2022

Inflammation is a normal response in defense to agents that may cause damage to the human body. When inflammation becomes chronic, reactive oxygen species (ROS) are produced; which could lead to diseases such as cancer. The aim was to assess liposomes’ antioxidant and anti-inflammatory capacity loaded with amaranth unsaponifiable matter and soybean lunasin (UM + LunLip) in an in vitro model using fibroblasts and macrophages. To evaluate ROS production, fibroblasts CHON-002 ABAP were added to promote ROS production; and the cells were treated with UM + LunLip. For inflammation markers production, lipopolysaccharides (LPS)-stimulated RAW 264.7 and peritoneal macrophages were treated with empty liposomes (EmLip), liposomes loaded with unsaponifiable matter (UMLip), liposomes loaded with lunasin (LunLip), and UM + LunLip. ROS production was significantly decreased by 77% (p < 0.05) when fibroblasts were treated with UM + LunLip at 2 mg lunasin/mL compared with the control treated with ABAP. Treatment with UMLip was the most effective in reducing tumor necrosis factor-α (71–90%) and interleukin-6 (43–55%, p < 0.001). Both liposomes containing unsaponifiable matter (UMLip and UM + LunLip) were more effective than EmLip or LunLip. In conclusion, amaranth unsaponifiable matter-loaded liposomes are effective in decreasing pro-inflammatory cytokine production.
New Prognostic Factors in Operated Extracapsular Hip Fractures: Infection and GammaTScore
Authors: Hernández-Pascual Carlos , Santos-Sánchez José Ángel , Hernández-Rodríguez Jorge , Silva-Viamonte Carlos Fernando , Pablos-Hernández Carmen , Villanueva-Martínez Manuel , Mirón-Canelo José Antonio
Published: September 2022

There is no universal postoperative classification of extracapsular hip fractures (ECFs). We wondered if infection (according to infection after fracture fixation criteria (IAFF)), immediate partial weight bearing (PWB) and/or the new GammaTScore tool could predict early cut-out. We also examined the correlation between GammaTScore and time to consolidation and studied long-term survival. This was a retrospective cohort study of low-energy complete ECFs operated with Gamma3T nailing in 2014 and fully monitoring, in patients aged over 65. Ten not distally locked cases, one late cut-out, one cut-through, one osteonecrosis and one pseudarthrosis were discarded. Patients were classified into early cut-out (7/204; 3.55%) and no early cut-out (197/204; 96.45%). There was a lower percentage of A2 fractures according to the AO Foundation/Orthopaedic Trauma Association classification (AO/OTA, 1997) in early cut-out. IAFF and only the GammaTScore reduction parameter were different for early cut-out, in opposition to immediate PWB, tip-to-apex distance (TAD) or the Baumgaertner–Fogagnolo classification. GammaTScore inversely correlated with consolidation (p < 0.01). Long-term survival time was not statistically significantly lower in the early cut-out group. Small sample of cases may limit our results. Apart from an important role of IAFF, GammaTScore would be useful for predicting consolidation, avoiding complications and reducing costs. Further studies are needed for reliability.
Difficult Therapeutic Decisions in Gorham-Stout Disease–Case Report and Review of the Literature
Authors: Wojciechowska-Durczynska Katarzyna , Zygmunt Arkadiusz , Mikulak Marta , Ludwisiak Marta , Lewinski Andrzej
Published: September 2022

Gorham-Stout disease (GSD) is a very rare, life-threatening condition characterized by the proliferation of lymphatic vessels and osteolysis. Unfortunately, no standard treatment has been determined for management of GSD. The available therapies are not equally effective and carry substantial side-effects. We report a 42-year-old female with GSD manifested in multifocal osteolysis and chronic chylothorax and ascites. The combined treatment with sirolimus and zoledronic acid due to its synergism of action was introduced. To our knowledge, this is the first Polish case report of adult patients with Gorham-Stout disease.
Mindfulness and Regulatory Emotional Self-Efficacy of Injured Athletes Returning to Sports: The Mediating Role of Competitive State Anxiety and Athlete Burnout
Authors: Tang Yiwei , Liu Yang , Jing Longjun , Wang Huilin , Yang Jingyu
Published: September 2022

Usually, both external environmental factors and internal psychological factors affect the self-efficacy of athletes returning to sports after an injury. Based upon COR theory, this study investigated mindfulness interventions’ effects on competitive state anxiety and burnout in injured athletes who are returning to sports. The study was conducted in South China from March to April 2022. The snowball and convenience sampling methods were used to select high-level sports teams’ injured athletes returning to sports, and a questionnaire survey was administered, from which 433 valid samples were obtained. Amos v. 26 was used to analyze the data. The results showed that mindfulness has a significant negative effect on competitive state anxiety and burnout, such that after strengthening the mindfulness intervention, athletes’ competitive state anxiety and burnout decreased and regulatory emotional self-efficacy increased. Further, this study indicated that athletes are prone to negative emotions after injury, and among athletes who returned to sports after injury, those with mindfulness interventions reported lower levels of competitive state anxiety and burnout. Hence, the study demonstrated that mindfulness can improve regulatory emotional self-efficacy in injured athletes who are returning to sports by reducing competitive state anxiety and burnout.
The Improvement Path for Regionally Coordinated Green Development: Evidence from Social Network Analysis
Authors: Zhou Yang , Wang Hankun , Wang Zuqiang , Dai Xiang
Published: September 2022

Regionally coordinated green development has been widely documented in China. However, most previous studies have investigated it from the perspective of linearity, while the spatial correlation of green development is nonlinear. Based on 48 cities in Bohai Rim, this study used a social network analysis to measure the spatial network, with an emphasis on the internal structure of regional green development, and analyzed the driving factors of regionally coordinated green development from the perspective of nonlinearity. We found that large cities have formed a “siphon effect” and that the polarization of eco-efficiency has become increasingly serious. There are limited connections, some of which are redundant, in the spatial network of green development, while the stability of the network is strong. Additionally, reducing the differences in environmental regulation approaches among cities can have a positive impact on the spatial correlation and spillover effect of green development, thereby promoting regionally coordinated green development among cities in the Bohai Rim.
Factors Associated with Musculoskeletal Disorders among Regular and Special Education Teachers: A Narrative Review
Authors: Abdul Rahim Ahmad Asyraf , Jeffree Mohammad Saffree , Ag Daud Dayang Maryama , Pang Nicholas , Sazali Mohd Fazeli
Published: September 2022

Musculoskeletal disorder (MSD) is a major health problem, which can lead to an enormous burden to the institution as well as chronic disability to the individual. Teachers are at risk of developing MSD due to the exposure to various ergonomic risk factors. Teachers of special education, for example, are expected to perform extra duty such as lifting and moving students, feeding food, changing diapers, and helping them in ambulation. Although there is an adequate amount of scientific research on MSD’s prevalence and its risk factors among regular teachers, only few studies have focused on special education teachers. This review aimed to address these gaps by describing the evidence from various papers on the prevalence of MSD among regular and special education teachers and the related risk factors. The papers have been gathered using electronic databases, including PubMed, Science Direct, Google Scholar, and Springer. The prevalence of MSD among regular teachers ranges from 48.7% to 73.7%, while the prevalence ranges from 38.7% to 94% in special education teachers. Risk factors, such as individual (age, duration of teaching, working hours, and work burden), physical (teaching activities, affected body areas), and psychological factors (stress, anxiety, fear), were identified. From the review, it is recommended to implement ergonomically designed workplaces, comprehensive ergonomic training, psychological approaches, and functional training among teachers at risk.
Decision Support Tools for Coronary Artery Calcium Scoring in the Primary Prevention of Cardiovascular Disease Do Not Meet Health Literacy Needs: A Systematic Environmental Scan and Evaluation
Authors: McKinn Shannon , Batcup Carys , Cornell Samuel , Freeman Natasha , Doust Jenny , Bell Katy J. L. , Figtree Gemma A. , Bonner Carissa
Published: September 2022

A shared decision-making approach is considered optimal in primary cardiovascular disease (CVD) prevention. Evidence-based patient decision aids can facilitate this but do not always meet patients’ health literacy needs. Coronary artery calcium (CAC) scans are increasingly used in addition to traditional cardiovascular risk scores, but the availability of high-quality decision aids to support shared decision-making is unknown. We used an environmental scan methodology to review decision support for CAC scans and assess their suitability for patients with varying health literacy. We systematically searched for freely available web-based decision support tools that included information about CAC scans for primary CVD prevention and were aimed at the public. Eligible materials were independently evaluated using validated tools to assess qualification as a decision aid, understandability, actionability, and readability. We identified 13 eligible materials. Of those, only one qualified as a decision aid, and one item presented quantitative information about the potential harms of CAC scans. None presented quantitative information about both benefits and harms of CAC scans. Mean understandability was 68%, and actionability was 48%. Mean readability (12.8) was much higher than the recommended grade 8 level. Terms used for CAC scans were highly variable. Current materials available to people considering a CAC scan do not meet the criteria to enable informed decision-making, nor do they meet the health literacy needs of the general population. Clinical guidelines, including CAC scans for primary prevention, must be supported by best practice decision aids to support decision-making.
The Trends and Hotspots in Premature Ovarian Insufficiency Therapy from 2000 to 2022
Authors: Tong Yan , Cheng Nan , Jiang Xinran , Wang Kai , Wang Fei , Lin Xinxin , Wang Fang
Published: September 2022

This study aims to map the knowledge structure and themes trends of primary ovarian insufficiency (POI) therapy to help researchers rapidly master the hotspots and prospects of POI therapy from the increasing number of publications. The literature search and bibliometric analyses were performed by using Web of Science Core Collection and VOSviewer. Annual publications from 2000 to 2022 continued to increase with some fluctuations. The most productive country, organization, and journal were the USA, Shanghai Jiao Tong University, and Human Reproduction, respectively. Harvard University was the organization with the highest citation. Fertility and Sterility and Nelson, L.M. were the most influential journal and author, respectively. Seven clusters separated by keywords association showed the extensive scope of POI therapy. The hotspots of POI therapy were hormone replacement therapy and fertility preservation, and the innovative treatment strategies including in vitro activation and mesenchymal stem cells had development potential. In addition, our result showed that the high-cited articles were published in journals with high impact factors. The paper provides a comprehensive overview of the development and hotspots of POI therapy, allowing researchers to recognize the current status and future directions of POI therapy.
How to Increase the Attractiveness of the Public Health Service in Germany as a Prospective Employer? Part II of the OeGD-Studisurvey
Authors: Arnold Laura , Kellermann Lisa , Fischer Florian , Hommes Franziska , Jung Laura , Mohsenpour Amir , Stratil Jan M.
Published: September 2022

The Public Health Service (PHS) in Germany has had difficulties in recruiting enough qualified staff for years, but there is limited research on what factors drive decisions to (not) join the PHS workforce. We explored reasons for this perceived (lack of) attractiveness. We conducted two cross-sectional surveys among medical students (MS), public health students and students from other PHS-relevant fields (PH&ONM) in Germany before (2019/2020) and during the COVID-19 pandemic (2021). Both waves surveyed self-reported reasons for why students did (not) consider working in the PHS as attractive and how this could be improved, using open-question items. Qualitative and quantitative content analyses were conducted according to Mayring. In total, 948 MS and 445 PH&ONM provided valid written responses. Reasons for considering the PHS as attractive were, among others, the perception of a good work-life balance, high impact, population health focus, and generally interesting occupations. Suggestions to increase attractiveness included reducing bureaucracy, modernization/digitalization, and more acknowledgement of non-medical professionals. Among MS, reasons against were too little clinical/patient-related activities, low salary, and occupations regarded as boring. Our findings indicate areas for improvement for image, working conditions in, and institutional structures of the PHS in Germany to increase its attractiveness as an employer among young professionals.
Full Arch Implant-Prosthetic Rehabilitation in Patients with Type I Diabetes Mellitus: Retrospective Clinical Study with 10 Year Follow-Up
Authors: D’Orto Bianca , Polizzi Elisabetta , Nagni Matteo , Tetè Giulia , Capparè Paolo
Published: September 2022

The aim of this retrospective clinical study was to evaluate and compare implant survival, marginal bone loss, and clinical and prosthetic complications in healthy patients and patients with type I diabetes undergoing full arch implant-prosthetic rehabilitation. A total of 47 patients needing total fixed rehabilitation of one or both arches were enrolled for this study. Based on the absence of any systemic diseases (Group A) or the presence of type I diabetes (Group B), the sample was divided into two groups. According to the grade of bone atrophy in the posterior region, patients received full arch rehabilitation (of one or both jaws) with 6 axial implants or, if the residual posterior bone height was insufficient, All-on-Four rehabilitation and a total 236 dental implants were placed. Follow-up visits were performed 1 week after surgery, at 3 and 6 months and then once a year for the next 10 years. No statistically significant differences between groups were recorded about implant survival rates, marginal bone loss, or clinical and prosthetic complications. However, concerning complications, post-surgical bleeding and wound infection were recorded in Group A more than in Group B. In cases of compensated diabetes compensation, implant placement could be considered a safe procedure.
Can Mobile Payment Increase Household Income and Mitigate the Lower Income Condition Caused by Health Risks? Evidence from Rural China
Authors: Qiu Weisong , Wu Tieqi , Xue Peng
Published: September 2022

China has moved into a new stage of its fight against poverty, where the further raising of rural household income is of great importance. Health risk is one of the biggest obstacles to the poverty reduction progress. Therefore, how to cope with the negative effects of health risks has attracted the attention of scholars, especially in the background of the global outbreak of COVID-19. In this paper, we try to explore whether mobile payment, a new form of payment, can improve the income of rural households and mitigate the lower income condition caused by health risks in China. Using data from the 2017 China Household Finance Survey, we found: (1) mobile payment can substantially increase rural household income; (2) health risks will lower the income of rural residents, but mobile payment can lessen this negative effect. Mechanism analysis indicates that mobile payment is likely to ease liquidity constraints, increase social interaction, and stimulate entrepreneurship for rural households. We advised the government to promote mobile payment adoption in rural areas and enhance its design. Additionally, better medical resources should also be made available to rural households.
Factors Influencing on Problem Solving Ability of Nursing Students Experiencing Simulation Practice
Authors: Jo Hyun Hee , Hwang Won Ju
Published: September 2022

It has become important for nurses to implement self-leadership and exercise critical thinking in problem-solving to address the health issues of patients. This has led to a need for nursing education programs in which nursing students learn to embrace self-leadership and self-evaluation approaches to develop their skills. Within 260 nursing undergraduates with experience in simulation practice as study subjects, a self-reporting survey was conducted on self-leadership, goal commitment, critical thinking, and problem-solving skills. An analysis was conducted using the SPSS/WIN 21.0 program. t-test and ANOVA were conducted to validate the difference between problem-solving abilities. Multiple regression was conducted to examine the impact of these variables on problem-solving skills. The variables of religion, satisfaction with major, goal commitment, and critical thinking were found to have a significant impact on problem-solving abilities. The results were as follows: critical thinking (β = 0.36, p < 0.05), goal commitment (β = 0.28, p < 0.05), and explanatory power of 41%. To improve the nursing undergraduates’ problem-solving abilities through simulation practice, there needs to be a method that supports them in setting goals with self-leadership and enhance goal commitment. The method also needs to support the development of their critical thinking and curiosity for questions deriving from experiencing diverse programs in order to deliver effective outcomes.
Verbal Autopsy as a Tool for Defining Causes of Death in Specific Healthcare Contexts: Study of Applicability through a Traditional Literature Review
Authors: Bailo Paolo , Gibelli Filippo , Ricci Giovanna , Sirignano Ascanio
Published: September 2022

Autopsy examination, the gold standard for defining causes of death, is often difficult to apply in certain health care settings, especially in developing countries. The COVID-19 pandemic and its associated difficulties in terms of implementing autopsy examinations have made the need for alternative means of determining causes of death even more evident. One of the most interesting alternatives to the conventional autopsy is the verbal autopsy, a tool that originated in Africa and Asia in the 1950s and consists of a structured interview with the deceased’s family members concerning the symptoms manifested by the person and the circumstances of death. In the early 1990s, the first doubts emerged about the validity of verbal autopsies, especially about the real reliability of the cause of death identified through this tool. The objective of the review was to identify studies that had assayed the validity of verbal autopsies through a rigorous comparison of the results that emerged from it with the results of conventional autopsies. When starting from an initial pool of 256 articles, only 2 articles were selected for final review. These are the only two original research articles in which a verbal autopsy validation process was performed by employing the full diagnostic autopsy as the gold standard. The two papers reached opposite conclusions, one suggesting adequate validity of verbal autopsy in defining the cause of death and the other casting serious doubts on the real applicability of this tool. Verbal autopsy undoubtedly has extraordinary potential, especially in the area of health and demographic surveillance, even considering the implementation that could result from the use of artificial intelligence and deep learning. However, at present, there appears to be a lack of solid data to support the robust reliability of this tool in defining causes of death.
Dynamic Balance and Chest Mobility of Older Adults after Speleotherapy Combined with Pulmonary Rehabilitation, Endurance and Strength Training—A Prospective Study in Chronic Respiratory Diseases
Authors: Mętel Sylwia , Kostrzon Magdalena , Adamiak Justyna
Published: September 2022

Backgrounds: As people age, they are more likely to experience balance disturbances. Pulmonary rehabilitation is recognized as a core component in the management of older adults with chronic respiratory diseases. The aim of the study was to assess the dynamic balance and chest mobility of older adults participating in speleotherapy combined with pulmonary rehabilitation, endurance and strength training. Methods: The study group consisted of 51 older adults with chronic respiratory disorders who participated in a 3-week pulmonary rehabilitation programme in underground salt chambers in the ‘Wieliczka’ Salt Mine Health Resort. These individuals underwent the Four Square Step Test (FSST) and circumferential chest mobility measurement before and after the outpatient rehabilitation programme conducted 135 m underground. Results: Before rehabilitation in the underground salt chambers, half of the results (50%, 22 patients) were below the norm in the assessment of chest mobility between maximal inhale and exhale. The average time needed to perform FSST decreased significantly (p ≤ 0.05) from 10.2 ± 1.9 s before the stay to 9.1 ± 1.7 s after the stay and the average increase in chest mobility increased significantly (p ≤ 0.05) from 4.5 ± 5.5 cm to 5.4 ± 2.8 cm. Conclusions: Speleotherapy combined with pulmonary rehabilitation, endurance and strength training increased the dynamic balance and chest mobility of older adults with chronic respiratory diseases, as measured by the FSST and circumferential chest expansion assessment.
Scales and Historical Evolution: Methods to Reveal the Relationships between Ecosystem Service Bundles and Socio-Ecological Drivers—A Case Study of Dalian City, China
Authors: Yan Xiaolu , Li Xinyuan , Liu Chenghao , Li Jiawei , Zhong Jingqiu
Published: September 2022

Ecosystem service (ES) bundles can be defined as the temporal and spatial co-occurrence of ESs. ES bundles are jointly driven by socio-ecological factors and form at different scales. However, in recent research, a few studies have analyzed the dynamic evolution and driving mechanisms of ES bundles at different scales. Therefore, this study explored the spatial patterns of six ESs supplied in Dalian (China) from 2005 to 2015 at three spatial scales, determining the distribution and evolution patterns of ES bundles and their responses to socio-ecological driving factors. Our results are as follows: (1) We identified four ES bundles representing ecological conservation, water conservation, ecological depletion, and food supply. The developmental trajectory of each ES bundle could be attributed to the combined effects of environmental conditions and urban expansion. In particular, the water conservation bundle and food supply bundle were changed to the ecological depletion bundle. Given the ongoing urbanization, the conflict between ESs has intensified. (2) The impact of socio-ecological driving factors on ES bundles vary with scale. At three spatial scales, the digital elevation model (DEM) and normalized difference vegetation index (NDVI) had a great impact on ES bundles. Urbanization indicators also strongly explain the spatial distribution of ES bundles at the county and grid scales. The interaction factor detector shows that there is no combination of mutual weakening, indicating that the formation of ES bundles is driven by multiple factors in Dalian. Overall, this study used a more holistic approach to manage the ecosystem by studying the temporal-spatial dynamics of the multiple ESs.
Perspectives of Licorice Production in Harsh Environments of the Aral Sea Regions
Authors: Khaitov Botir , Karimov Aziz , Khaitbaeva Jamila , Sindarov Obidjon , Karimov Akmal , Li Yongqing
Published: September 2022

Along with pharmacological applications due to bioactive elements such as flavonoids and glycyrrhizin, licorice has positive influences on the rehabilitation, rejuvenation, and management of salt-affected degraded lands in arid regions. These features made this plant widely appreciated worldwide when climate change is showing detrimental impacts for crop production and food security. However, a growing demand followed by irrational harvesting of wild licorice plants has led to substantial dwindling of its natural habitat. There is an increasing need to protect the plant biodiversity since sustainability can be a problem with wild harvesting. Therefore, it is important to investigate cultivation technologies of licorice under harsh environments, while this plant can adapt to a wide range of climates. Thus, in this review, we studied, analyzed and summarized the literature on licorice cultivation methods counteracting the most common environmental stresses in the Aral Sea region. Particularly, the current knowledge was rationalized regarding on cultivation technologies for alleviating salt stress thereby improving crop production. We also highlighted that future research directions on licorice breeding and genomics that might facilitate to produce more resilient and sustainable licorice genotypes to renovate agricultural productivity under disastrous ecology and climate change of the arid regions. Whereas this area possesses all prerequisite conditions needed for successful cultivation of the alternative cash crop.
Alleviating Doctors’ Emotional Exhaustion through Sports Involvement during the COVID-19 Pandemic: The Mediating Roles of Regulatory Emotional Self-Efficacy and Perceived Stress
Authors: Wang Huilin , Zheng Xiao , Liu Yang , Xu Ziqing , Yang Jingyu
Published: September 2022

This study aims to understand the state of emotional exhaustion of Chinese doctors during the COVID-19 pandemic, and explore the role of sports involvement in enhancing doctors’ regulatory emotional self-efficacy, reducing stress perception, and alleviating emotional exhaustion. Finally, report the existing problems and make recommendations to the government and hospitals. The researchers constructed a cross-sectional questionnaire survey to collect data. From March to April 2022, using the snowball and convenience sampling methods, a total of 413 valid questionnaires were collected from 13 hospitals in Hunan Province. AMOS 23.0 was used to construct a structural equation model (SEM) with the bootstrapping approach to verify the proposed hypotheses. Doctors with more sports involvement exhibited higher levels of regulatory emotional self-efficacy and lesser perceived stress. Doctors who exhibited higher regulatory emotional self-efficacy had lesser perceived stress. The relationship between sports involvement and emotional exhaustion was mediated by perceived stress and/or regulatory emotional self-efficacy. Therefore, the government and hospitals should strengthen the depth and intensity of implementing the “National Fitness Program” at the hospital level, instead of just holding short-term activities with a small number of participants, but to cover all medical staff with fitness opportunities.
Number of Births and Later-Life Depression in Older Adults: Evidence from China
Authors: Xue Kaiyun , Nie Yafeng , Wang Yue , Hu Zhen
Published: September 2022

Previous studies on the number of births and the health of the elderly have been highly focused on physical health and used samples from developed countries. Therefore, this study aimed to explore the effect of the lifetime number of births on depression in Chinese older adults. We used panel data for men and women aged 50 and over from the 2013–2018 China Health and Retirement Longitudinal Study. Depressive symptoms were assessed through a short form of the Center for Epidemiologic Studies Depression Scale. We found that depression levels in women were significantly higher than in men, with a mean difference of 2.44 (p < 0.001). The model estimation results indicated that the number of births affected depression in older adults, and its increase could exacerbate depression in older adults. The number of births significantly impacted depression among the elderly aged 50–69. Furthermore, there was a negative relationship between the proportion of sons and older adults’ depression, which was significant in older males; the number of abortions may exacerbate depression in older adults, especially in females.
The Association between Hand Disinfection Techniques and Their Barriers, as Well as the “Bare below the Elbows” Concept, among Healthcare Professionals—A Study Based on a Polish Population
Authors: Szumska Emilia , Czajkowski Przemyslaw , Zablocki Michal , Rozkiewicz Dorota
Published: September 2022

Hand hygiene is the most effective way to prevent nosocomial infections. Nevertheless, the hands of healthcare professionals are still the primary route of transmission of pathogens responsible for such infections. The aim of this study was to evaluate hand disinfection techniques and investigate the risk factors that may explain the improper hand disinfection techniques among healthcare workers. We selected 7544 hospital workers directly involved in patient care. We recorded data based on the questionnaires, demographic data, and the preparation of hands for disinfection, including risk factors. Correct hand disinfection was verified by COUCOU BOX, with a UV camera. Proper hand disinfection was demonstrated among 4879 (64.7%) subjects, while 2665 (35.3%) subjects disinfected their hands incorrectly. In most places of work, nurses properly disinfected their hands more often than the physicians, particularly in general departments (62.1% vs. 69.2%; p = 0.0019). We observed that long nails and artificial/polished nails were more often observed in the group of nurses than in the group of physicians (7.3% vs. 4.7%, respectively; p = 0.0006 and 19.3% vs. 10.1%; p = 0.0000), while an inverse relationship was found in relation to watches (24.0% vs. 12.0%; p = 0.0000) and long sleeves (24.4% vs. 8.1%; p = 0.0000). Incorrect and less effective hand hygiene among some groups of hospital workers is still present. Therefore, the continuation of education actions concerned with hand hygiene among healthcare workers is needed.
Exploring Users’ Health Behavior Changes in Online Health Communities: Heuristic-Systematic Perspective Study
Authors: Gong Liyue , Jiang Hao , Wu Xusheng , Kong Yi , Gao Yunyun , Liu Hao , Guo Yi , Hu Dehua
Published: September 2022

(1) Background: With the continuous advancement of internet technology, use of the internet along with medical service provides a new solution to solve the shortage of medical resources and the uneven distribution of available resources. Online health communities (OHCs) that emerged at this historical moment have flourished with various advantages, such as being free from location and time constraints. Understanding users’ behavior changes via engagement in OHCs is necessary to support the development of internet medicine and promote public health. (2) Methods: The hypotheses of our research model were developed based on the protective action decision model (PADM) and heuristic-systematic model (HSM). A questionnaire was developed with seven constructs through previous studies and verified using a presurvey. Our survey respondents are online health community users. We used structural equation modelling to test the research hypotheses. (3) Results: The results of the analysis of 290 valid samples showed that the research model fit the data collected well. The perceived benefits (PB) positively affect information needs (IN) (beta = 0.280, p < 0.001, R2 = 0.252), thereby promoting users’ engagement in OHCs (EOHCs) (beta = 0.353, p < 0.001, R2 = 0.387); EOHCs has a significant positive impact on health behavior change (HBC) (beta = 0.314, p < 0.001), and it also significantly positively affects users’ health behavior change through systematic processing indirectly (beta = 0.252, p < 0.001, R2 = 0.387). (4) Conclusions: Our study offers support for the usefulness of the PADM and HSM in explaining users’ health behavior changes. For practitioners, this study introduces influence processes as policy tools that managers can employ for health-promoting with mHealth.
Exploration of Multilevel Barriers and Strategies That Affected Early COVID-19 Vaccination and Testing in Rural Latino Communities in Southwest Florida
Authors: Buro Acadia W. , Roman Candelaria Kevin , Bailey Rocio , Luna Frances , Albizu-Jacob Alexandra , Stern Marilyn , Redwine Laura
Published: September 2022

The COVID-19 pandemic has disproportionately impacted multiple racial and ethnic minority groups, including Latinos residing in rural communities. Low rates of vaccination and testing combined with social determinants of health have contributed significantly to this disparate impact. Given the needs and constraints unique to rural Latino migrant and immigrant communities, this qualitative study examined multilevel barriers and strategies that affect COVID-19 vaccination and testing uptake among these communities in southwest Florida. Four focus groups (n = 25) were conducted between March and April 2021 with various key stakeholders, including rural Latino community members, local leaders, and community health workers (‘Promotoras de Salud’). Themes that aligned with barriers to COVID-19 vaccination and testing included fear, lack of control, misinformation, lack of accessibility, and institutional/policy issues; themes that aligned with strategies to improve COVID-19 vaccination and testing uptake included faith, taking care of self, and community and family resilience. Recommendations for improving future pandemic responses for rural Latino communities include incorporating multiple levels of intervention, such as consideration of the role of the family, involving trusted community members, and ensuring the development and implementation of fair and consistent policies.
Mortality and Causes of Death among Individuals Diagnosed with Human Immunodeficiency Virus in Korea, 2004–2018: An Analysis of a Nationwide Population-Based Claims Database
Authors: Park Boyoung , Choi Yunsu , Kim Jung Ho , Seong Hye , Kim Youn Jeong , Lee Myungsun , Seong Jaehyun , Kim Shin-Woo , Song Joon Young , Choi Hee-Jung , Park Dae Won , Kim Hyo Youl , Choi Jun Yong , Kim Sang Il , Choi Bo-Youl
Published: September 2022

The mortality rate and causes of death among individuals diagnosed with human immunodeficiency virus (HIV) infection in Korea were described and compared to those of the general population of Korea using a nationwide population-based claims database. We included 13,919 individuals aged 20–79 years newly diagnosed with HIV between 2004 and 2018. The patients’ vital status and cause of death were linked until 31 December 2019. Standardized mortality ratios (SMRs) for all-cause death and specific causes of death were calculated. By the end of 2019, 1669 (12.0%) of the 13,919 HIV-infected participants had died. The survival probabilities of HIV-infected individuals at 1, 5, 10, and 15 years after diagnosis in Korea were 96.2%, 91.6%, 85.9%, and 79.6%, respectively. The main causes of death during the study period were acquired immunodeficiency syndrome (AIDS; 59.0%), non-AIDS-defining cancer (8.2%), suicide (7.4%), cardiovascular disease (4.9%), and liver disease (2.7%). The mortality rate of men and women infected with HIV was 5.60-fold (95% CI = 5.32–5.89) and 6.18-fold (95% CI = 5.30–7.09) that of men and women in the general population, respectively. After excluding deaths due to HIV, the mortality remained significantly higher, with an SMR of 2.16 (95% CI = 1.99–3.24) in men and 3.77 (95% CI = 3.06–4.48) in women. HIV-infected individuals had a higher overall mortality than the general population, with AIDS the leading cause of mortality. Additionally, mortality due to non-AIDS-related causes was higher in HIV-infected individuals.
The Influence of Leader Bottom-Line Mentality on Miners’ Safety Behavior: A Moderated Parallel Mediation Model Based on the Dual-System Theory
Authors: Niu Lixia , Xia Wende , Qiao Yafan
Published: September 2022

As a high-risk industry that is always struggling with unsafe factors, coal mine enterprises must prioritize safety in their operation and management, but there are still some short-sighted coal mine managers who choose to leave safety behind in the desperate pursuit of financial benefits, resulting in coal mine accidents from time to time. Unfortunately, this leadership style, known as leader bottom-line mentality, has not yet received sufficient attention in the safety field. Based on dual-system theory, this study aimed to explore the mediating role of emotional exhaustion and safety consciousness between leader bottom-line mentality and miners’ safety behavior, as well as the moderating role of Chinese traditionality. Using a sample of 422 frontline miners in China, the results of the data analysis showed that emotional exhaustion and safety consciousness played parallel mediating roles between leader bottom-line mentality and miners’ safety behavior, and Chinese traditionality moderated the effect of leader bottom-line mentality: the higher the Chinese traditionality, the weaker the mediating effect of emotional exhaustion and the stronger the mediating effect of safety consciousness. Present research explains the mechanisms and boundaries of the influence of leader bottom-line mentality on miners’ safety behavior, contributing to the emerging literature on safety management and bottom-line mentality.
R17C Mutation in Photoreceptor Disc-Specific Protein, PRCD, Results in Additional Lipidation Altering Protein Stability and Subcellular Localization
Authors: Myers Boyden , Sechrest Emily R. , Hamner Gabrielle , Motipally Sree I. , Murphy Joseph , Kolandaivelu Saravanan
Published: September 2022

Progressive rod-cone degeneration (PRCD) is a photoreceptor outer segment (OS) disc-specific protein essential for maintaining OS structures while contributing to rhodopsin packaging densities and distribution in disc membranes. Previously, we showed PRCD undergoing palmitoylation at the sole cysteine (Cys2), where a mutation linked with retinitis pigmentosa (RP) in humans and dogs demonstrates the importance of palmitoylation for protein stability and trafficking to the OS. We demonstrate a mutation, in the polybasic region (PBR) of PRCD (Arg17Cys) linked with RP where an additional lipidation is observed through acyl-RAC. Immunolocalization of transiently expressed R17C in hRPE1 cells depicts similar characteristics to wild-type PRCD; however, a double mutant lacking endogenous palmitoylation at Cys2Tyr with Arg17Cys is comparable to the C2Y protein as both aggregate, mislocalized to the subcellular compartments within the cytoplasm. Subretinal injection of PRCD mutant constructs followed by electroporation in murine retina exhibit mislocalization in the inner segment. Despite being additionally lipidated and demonstrating strong membrane association, the mutation in the PBR affects protein stability and localization to the OS. Acylation within the PBR alone neither compensates for protein stability nor trafficking, revealing defects in the PBR likely lead to dysregulation of PRCD protein associated with blinding diseases.
Chloroplast Genome Annotation Tools: Prolegomena to the Identification of Inverted Repeats
Authors: Turudić Ante , Liber Zlatko , Grdiša Martina , Jakše Jernej , Varga Filip , Šatović Zlatko
Published: September 2022

The development of next-generation sequencing technology and the increasing amount of sequencing data have brought the bioinformatic tools used in genome assembly into focus. The final step of the process is genome annotation, which works on assembled genome sequences to identify the location of genome features. In the case of organelle genomes, specialized annotation tools are used to identify organelle genes and structural features. Numerous annotation tools target chloroplast sequences. Most chloroplast DNA genomes have a quadripartite structure caused by two copies of a large inverted repeat. We investigated the strategies of six annotation tools (Chloë, Chloroplot, GeSeq, ORG.Annotate, PGA, Plann) for identifying inverted repeats and analyzed their success using publicly available complete chloroplast sequences of taxa belonging to the asterid and rosid clades. The annotation tools use two different approaches to identify inverted repeats, using existing general search tools or implementing stand-alone solutions. The chloroplast sequences studied show that there are different types of imperfections in the assembled data and that each tool performs better on some sequences than the others.
Extended N-Terminal Acetyltransferase Naa50 in Filamentous Fungi Adds to Naa50 Diversity
Authors: Weidenhausen Jonas , Kopp Jürgen , Ruger-Herreros Carmen , Stein Frank , Haberkant Per , Lapouge Karine , Sinning Irmgard
Published: September 2022

Most eukaryotic proteins are N-terminally acetylated by a set of Nα acetyltransferases (NATs). This ancient and ubiquitous modification plays a fundamental role in protein homeostasis, while mutations are linked to human diseases and phenotypic defects. In particular, Naa50 features species-specific differences, as it is inactive in yeast but active in higher eukaryotes. Together with NatA, it engages in NatE complex formation for cotranslational acetylation. Here, we report Naa50 homologs from the filamentous fungi Chaetomium thermophilum and Neurospora crassa with significant N- and C-terminal extensions to the conserved GNAT domain. Structural and biochemical analyses show that CtNaa50 shares the GNAT structure and substrate specificity with other homologs. However, in contrast to previously analyzed Naa50 proteins, it does not form NatE. The elongated N-terminus increases Naa50 thermostability and binds to dynein light chain protein 1, while our data suggest that conserved positive patches in the C-terminus allow for ribosome binding independent of NatA. Our study provides new insights into the many facets of Naa50 and highlights the diversification of NATs during evolution.