bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Significance of Intraoperative Exposure of Inferior Alveolar Nerve during Surgical Extraction of the Mandibular Third Molar in Nerve Injury
Authors: On Sung-Woon , Cho Seoung-Won , Byun Soo-Hwan , Yang Byoung-Eun
Published: September 2021

During extraction surgery, the inferior alveolar nerve (IAN) can occasionally be observed in the extraction socket of the mandibular third molar (M3). The purpose of this study was to investigate and compare the incidence of IAN injury in groups with and without intraoperative IAN exposure during surgical extraction of M3, and to identify additional risk factors for the IAN injury in addition to the IAN exposure. A total of 288 cases in 240 patients, who underwent surgical extraction of M3 by a single surgeon, were divided into the exposed group (n = 69) and the unexposed group (n = 219). The surgeon recorded the information regarding the procedure when the clinical observation of IAN exposure was made during the surgery. The incidence of IAN injury after the extraction surgery was significantly higher in the exposed group than in the unexposed group (4.3% versus 0%, p < 0.05). Paresthesia was recognized in three cases of the exposed group, but it showed complete recovery within three postoperative months. No case of permanent paresthesia was detected in both groups. According to the logistic regression, the only significant risk factor of IAN injury in the exposed group was the increase of age (OR 1.108, p < 0.05). Intraoperative IAN exposure during surgical extraction of M3 may show a higher incidence of IAN injury than the case without IAN exposure, representing an incidence of 4.3%. Even if the paresthesia associated with IAN exposure occurs, it is likely to be a temporary injury, and this risk may increase with age.
Acute Effects of High Doses of Caffeine on Bar Velocity during the Bench Press Throw in Athletes Habituated to Caffeine: A Randomized, Double-Blind and Crossover Study
Authors: Filip-Stachnik Aleksandra , Krzysztofik Michal , Del Coso Juan , Wilk Michal
Published: September 2021

Chronic intake of caffeine may produce a reduction in the potential performance benefits obtained with the acute intake of this substance. For this reason, athletes habituated to caffeine often use high doses of caffeine (≥9 mg/kg) to overcome tolerance to caffeine ergogenicity due to chronic intake. The main objective of the current investigation was to evaluate the effects of high caffeine doses on bar velocity during an explosive bench press throw in athletes habituated to caffeine. Twelve resistance-trained athletes, with a moderate-to-high chronic intake of caffeine (~5.3 mg/kg/day) participated in a randomized double-blind and randomized experimental design. Each participant performed three identical experimental sessions 60 min after the intake of a placebo (PLAC) or after the intake of 9 (CAF-9) or 12 mg/kg (CAF-12) of caffeine. In each experimental session, the athletes performed five sets of two repetitions of the bench press throw exercise with a load equivalent to 30% of their one-repetition maximum. In comparison to PLAC, the intake of caffeine increased peak and mean velocity (p < 0.01) during the five sets of the bench press throw exercise. There were no significant differences in peak and mean bar velocity between the two doses of caffeine (CAF-9 vs. CAF-12; p = 0.91, = 0.96, respectively). The ingestion of high doses of caffeine was effective in producing an increase in mean and peak bar velocity during the bench press throw in a group of habitual caffeine users. However, using CAF-12 did not offer additional benefits for performance with respect to CAF-9.
Dependence of Heart Rate Variability Indices on the Mean Heart Rate in Women with Well-Controlled Type 2 Diabetes
Authors: Robles-Cabrera Adriana , Torres-Arellano José M. , Fossion Ruben , Lerma Claudia
Published: September 2021

Heart rate variability (HRV) is a method used to evaluate the presence of cardiac autonomic neuropathy (CAN) because it is usually attributed to oscillations in cardiac autonomic nerve activity. Recent studies in other pathologies suggest that HRV indices are strongly related to mean heart rate, and this does not depend on autonomic activity only. This study aimed to evaluate the correlation between the mean heart rate and the HRV indices in women patients with well-controlled T2DM and a control group. HRV was evaluated in 19 T2DM women and 44 healthy women during basal supine position and two maneuvers: active standing and rhythmic breathing. Time-domain (SDNN, RMSSD, pNN20) and frequency-domain (LF, HF, LF/HF) indices were obtained. Our results show that meanNN, age, and the maneuvers are the main predictors of most HRV indices, while the diabetic condition was a predictor only for pNN20. Given the known reduced HRV in patients with T2DM, it is clinically important that much of the HRV indices are dependent on heart rate irrespective of the presence of T2DM. Moreover, the multiple regression analyses evidenced the multifactorial etiology of HRV.
Clinical and Epidemiological Features of Tuberculous Pleural Effusion in Alicante, Spain
Authors: Chiner Eusebi , Nomdedeu Miriam , Vañes Sandra , Pastor Esther , Esteban Violeta , Castelló Carmen , Boira Ignacio , Molina Virginia , Arriero Juan M. , Sancho-Chust Jose N.
Published: September 2021

We aimed to (1) evaluate the incidence of tuberculous pleural effusion (TPE) over 25 years in our centre; (2) measure the yield of different diagnostic techniques; (3) compare TPE features between immigrant and native patients. Retrospective study of patients who underwent diagnostic thoracentesis and pleural biopsy in our hospital between 1995 and 2020. TPE was diagnosed in 71 patients (65% natives, 35% immigrants). Onset was acute in 35%, subacute in 26% and prolonged in 39%. Radiological features were atypical in 42%. Thoracentesis specimens were lymphocyte-predominant in 84.5% of patients, with elevated adenosine deaminase in 75% of patients. Diagnostic yield of pleural biopsy was 78%. Compared with native patients, more immigrants had previous contact with TB (54% vs. 17%, p = 0.001), prior TB (21% vs. 4%, p < 0.02) and atypical radiological features (58% vs. 34%, p < 0.03). TPE incidence was six times higher in the immigrant population (6.7 vs. 1.1 per 100,000 person-years, p < 0.001). TPE has an acute onset and sometimes atypical radiological features. Pleural biopsy has the highest diagnostic yield. Reactivation, prior contact with TB, atypical radiological features, complications, and positive microbiology results are more common in immigrant patients.
From Basic Mechanisms to Clinical Research: Photodynamic Therapy Applications in Head and Neck Malignancies and Vascular Anomalies
Authors: Ramsay Daniele , Stevenson Harvey , Jerjes Waseem
Published: September 2021

Head and neck cancers are largely squamous cell carcinomas derived from the epithelial lining of the structures in the region, and are often classified anatomically into oral, oropharyngeal, nasopharyngeal and laryngeal carcinomas. The region’s component structures serve complex and intricate functions, such as speaking, swallowing and breathing, which are often compromised by these neoplasms. Such lesions may also cause disfigurement, leading to distressing social and psychological issues. Conventional treatments of these neoplasms usually involve surgical intervention with or without chemoradiotherapy. These have shown to be efficacious; however, they can also cause damage to healthy as well as diseased tissue, exacerbating the aforementioned problems. Access to a given region to deliver the treatments is also often a problem, due to the complex anatomical structures involved. The use of photodynamic therapy in the head and neck region has been established for about two decades. In this review, we looked at the basic mechanisms of this intervention, examined its use in common head and neck malignancies and vascular anomalies, and reported on the most recent clinical studies. We further included a clinical guide which can help replicate the use of this technology by any unit. Based on this review, photodynamic therapy has been shown to be efficacious in the treatment of head and neck malignancies and vascular tumours. This therapy can be targeted to the diseased tissue and causes no damage to underlying structures. Recent studies have shown this therapy to be as effective as conventional therapies, without causing major adverse effects.
Acute-on-Chronic Liver Failure in Cirrhosis
Authors: Gambino Carmine , Piano Salvatore , Angeli Paolo
Published: September 2021

Acute-on-chronic liver failure (ACLF) is a syndrome that develops in patients with acutely decompensated chronic liver disease. It is characterised by high 28-day mortality, the presence of one or more organ failures (OFs) and a variable but severe grade of systemic inflammation. Despite the peculiarity of each one, every definition proposed for ACLF recognizes it as a proper clinical entity. In this paper, we provide an overview of the diagnostic criteria proposed by the different scientific societies and the clinical characteristics of the syndrome. Established and experimental treatments are also described. Among the former, the most relevant are directed to support organ failures, treat precipitating factors and carry out early assessment for liver transplantation (LT). Further studies are needed to better clarify pathophysiology of the syndrome and discover new therapies.
Increased Risks of Death and Hospitalization in Influenza/Pneumonia and Sepsis for Individuals Affected by Psychotic Disorders, Bipolar Disorders, and Single Manic Episodes: A Retrospective Cross-Sectional Study
Authors: Nilsson Niklas , Bendix Marie , Öhlund Louise , Widerström Micael , Werneke Ursula , Maripuu Martin
Published: September 2021

Individuals with severe mental disorders (SMDs) such as psychotic disorders, bipolar disorders, and single manic episodes have increased mortality associated with COVID-19 infection. We set up a population-based study to examine whether individuals with SMD also had a higher risk of hospitalization and death from other infectious conditions. Anonymized and summarized data from multiple Swedish patient registers covering the entire Swedish population were supplied by the Swedish National Board of Health and Welfare. The frequencies of hospitalizations and deaths associated with influenza/pneumonia and sepsis in individuals with SMD were compared with the rest of the population during 2018–2019. Possible contributing comorbidities were also examined, of which diabetes, cardiovascular disease, chronic lung disease, and hypertension were chosen. A total of 7,780,727 individuals were included in the study; 97,034 (1.2%) cases with SMD and 7,683,693 (98.8%) controls. Individuals with SMD had increased risk of death associated with influenza/pneumonia (OR = 2.06, 95% CI [1.87–2.27]) and sepsis (OR = 1.61, 95% CI [1.38–1.89]). They also had an increased risk of hospitalization associated with influenza/pneumonia (OR = 2.12, 95% CI [2.03–2.20]) and sepsis (OR = 1.89, 95% CI [1.75–2.03]). Our results identify a need for further evaluation of whether these individuals should be included in prioritized risk groups for vaccination against infectious diseases other than COVID-19.
Polypharmacy Is Significantly and Positively Associated with the Frailty Status Assessed Using the 5-Item FRAIL Scale, Cardiovascular Health Phenotypic Classification of Frailty Index, and Study of Osteoporotic Fractures Scale
Authors: Hung Chi-Di , Yang Chen-Cheng , Lee Chun-Ying , Hu Stephen Chu-Sung , Chen Szu-Chia , Hung Chih-Hsing , Chuang Hung-Yi , Chen Ching-Yu , Kuo Chao-Hung
Published: September 2021

The aim of this study was to investigate the association between frailty and polypharmacy using three different frailty screening tools. This was a cross-sectional study of people aged ≥65 years. Participants were included and interviewed using questionnaires. Polypharmacy was defined as the daily use of eight or more pills. Frailty was assessed using a screening tool, including (1) the Fatigue, Resistance, Ambulation, Illness and Loss of Weight Index (5-item FRAIL scale), (2) the Cardiovascular Health Phenotypic Classification of Frailty (CHS_PCF) index (Fried’s Frailty Phenotype), and (3) the Study of Osteoporotic Fracture (SOF) scale. A total of 205 participants (mean age: 71.1 years; 53.7% female) fulfilled our inclusion criteria. The proportion of patients with polypharmacy was 14.1%. After adjustments were made for comorbidity or potential confounders, polypharmacy was associated with frailty on the 5-item FRAIL scale (adjusted odds ratio [aOR]: 9.12; 95% confidence interval [CI]: 3.6–23.16), CHS_PCF index (aOR: 8.98; 95% CI: 2.51–32.11), and SOF scale (aOR: 6.10; 95% CI: 1.47–25.3). Polypharmacy was associated with frailty using three frailty screening tools. Future research is required to further enhance our understanding of the risk of frailty among older adults.
Global Glaucoma Staging System (GGSS): A New Method to Simultaneously Assess the Severity of Both Functional and Structural Damage in Glaucoma
Authors: Brusini Paolo
Published: September 2021

Background: The classification of damage in glaucoma is usually based either on visual field or optical coherent tomography (OCT) assessment. No currently available method is able to simultaneously categorize functional and structural damage. Material and Methods: In this study, 283 patients with chronic open-angle glaucoma (OAG) at different stages and 67 healthy subjects were tested with both standard automated perimetry and spectral domain OCT for retinal nerve fiber layer (RNFL) assessment. The visual field data were classified using the Glaucoma Staging System 2, whereas OCT results were processed with the OCT Glaucoma Staging System. These data were used to create a new staging system (global glaucoma staging system, GGSS), in which the severity of visual field and RNFL damage is reported on the Y and X axis, respectively. The GGSS was tested in a different sample of 147 patients with manifest OAG, 56 with preperimetric glaucoma and 43 normal subjects. A six-stage clinical classification, based on the analysis of visual fields and optic disc appearance, was used as gold standard. Results: The GGSS was able to correctly classify in the same stage or within the immediately adjacent stages 145 cases on 147 (98.6%). Fifty-four preperimetric cases (96.4%) were classified as borderline or abnormal (Stage 1 or 2). Here, 41 normal eyes out of 43 were correctly classified as Stage 0, with a specificity of 95.3%. Conclusions: Preliminary results from this study are encouraging and suggest that the new GGSS is able to provide information concerning the severity of structural and functional damage in an integrated manner.
Cardiotoxicity of Fluoropyrimidines: Epidemiology, Mechanisms, Diagnosis, and Management
Authors: Jurczyk Michał , Król Magdalena , Midro Aleksandra , Kurnik-Łucka Magdalena , Poniatowski Adrian , Gil Krzysztof
Published: September 2021

Cancer is a growing public health problem; it is responsible annually for millions of deaths worldwide. Fluoropyrimidines are highly effective and commonly prescribed anti-neoplastic drugs used in a wide range of chemotherapy regimens against several types of malignancies. 5-fluorouracil and its prodrugs affect neoplastic cells in multiple ways by impairing their proliferation, principally through the inhibition of thymidylate synthase. Fluoropyrimidine-induced cardiotoxicity was described more than 50 years ago, but many details such as incidence, mechanisms, and treatment are unclear and remain disputed. Severe cardiotoxicity is not only life-threatening, but also leads to withdrawal from an optimal chemotherapy regimen and decreases survival rate. Differences in the frequency of cardiotoxicity are explained by different chemotherapy schedules, doses, criteria, and populations. Proposed pathophysiological mechanisms include coronary vasospasm, endothelial damage, oxidative stress, Krebs cycle disturbances, and toxic metabolites. Such varied pathophysiology of the cardiotoxicity phenomenon makes prevention and treatment more difficult. Cardiovascular disturbances, including chest pain, arrhythmias, and myocardial infarction, are among the most common side effects of this class of anti-neoplastic medication. This study aims to summarize the available data on fluoropyrimidine cardiotoxicity with respect to symptoms, incidence, metabolism, pathophysiological mechanism, diagnosis, management, and resistance.
Endovascular Treatment of Chronic Subdural Hematomas through Embolization: A Pilot Study with a Non-Adhesive Liquid Embolic Agent of Minimal Viscosity (Squid)
Authors: Petrov Andrey , Ivanov Arkady , Rozhchenko Larisa , Petrova Anna , Bhogal Pervinder , Cimpoca Alexandru , Henkes Hans
Published: September 2021

Objective: Endovascular embolization using non-adhesive agents (e.g., ethylene vinyl alcohol copolymer with suspended micronized tantalum dissolved in dimethyl sulfoxide; Squid, Balt Extrusion) is an established treatment of brain arteriovenous malformations, dural arteriovenous fistulas, and hypervascular neoplasms. Middle meningeal artery (MMA) embolization is a relatively new concept for treating chronic subdural hematomas (CSDH). This study aimed to evaluate the safety and effectiveness of the use of Squid in the endovascular treatment of CSDH. Methods: Embolization was offered to patients with CSDH with minimal or moderate neurological deficits and patients who had previously undergone open surgery to evacuate their CSDH without a significant effect. Distal catheterization of the MMA was followed by embolization of the hematoma capsule with Squid 12 or Squid 18. Safety endpoints were ischemic or hemorrhagic stroke and any other adverse event of the endovascular procedure. Efficacy endpoints were the feasibility of the intended procedure and a ≥ 50% reduction of the maximum depth of the CSDH confirmed by follow-up computed tomography (CT) after >3 months. Results: Between November 2019 and July 2021, 10 patients (3 female and 7 male, age range 42–89 years) were enrolled. Five patients had bilateral hematomas, and five patients had previously been operated on with no significant effect and recurrent hematoma formation. The attempted embolization was technically possible in all patients. No technical or clinical complication was encountered. During a post-procedural follow-up (median 90 days), 10 patients improved clinically. A complete resolution of the CSDH was observed in 10 patients. The clinical condition of all enrolled patients during the so-far last contact was rated mRS 0 or 1. Conclusion: A distal catheterization of the MMA for the endovascular embolization of CSDH with Squid allowed for the devascularization of the MMA and the dependent vessels of the hematoma capsule. This procedure resulted in a partial or complete resolution of the CSDH. Procedural complications were not encountered.
Ulipristal Acetate Modifies miRNA Expression in Both Superficial and Basal Layers of the Human Endometrium
Authors: Kolanska Kamila , Sbeih Maria , Canlorbe Geoffroy , Mekinian Arsène , Varinot Justine , Capmas Perrine , Koskas Martin , Aractingi Selim , Daraï Emile , Chabbert-Buffet Nathalie
Published: September 2021

(1) Background: Ulipristal acetate (UPA) is a selective progesterone receptor modulator (SPRM) widely used for emergency contraception and mid- to long-term leiomyoma treatment. The aim of this study was to identify modifications of miRNA expression in superficial and basal layers of the human endometrium at the end of the UPA treatment for at least 3 months. (2) Methods: Microarray miRNA analysis of formalin-fixed, paraffin-embedded hysterectomy tissue samples was conducted, followed by an Ingenuity Pathway Analysis. Samples were divided into three groups: women having had 3 months of UPA treatment (n = 7); and two control groups of UPA-naïve women in the proliferative (n = 8) or secretory (n = 6) phase. (3) Results: The UPA modified the expression of 59 miRNAs involved in the processes of cell cycle, carcinogenesis, and inflammation. Their expression profiles were different in the basal and superficial layers. Most of the processes influenced by the UPA in the basal layer were connected to the cell cycle and immune regulation. (4) Conclusion: Specific changes were observed in both layers of the endometrium in the UPA group. However, the miRNA expression in the basal layer was not consistent with that in the superficial layer. Other large studies analysing the long-term impact of SPRM on endometrial miRNA expression are necessary.
The Use of Agricultural Waste in the Modification of Poly(lactic acid)-Based Composites Intended for 3D Printing Applications. The Use of Toughened Blend Systems to Improve Mechanical Properties
Authors: Andrzejewski Jacek , Grad Karolina , Wiśniewski Wojciech , Szulc Joanna
Published: September 2021

The presented research focused on improving the mechanical properties of PLA-based composites reinforced with buckwheat husks (BH) particles. The research work was carried out in two stages. Firstly, the blend was prepared with the addition of polybutylene adipate terephthalate (PBAT) and thermoplastic starch (TPS), manufactured by injection molding technique, then the selected materials were prepared with the addition of BH filler, and the samples were prepared using the fused deposition modeling method (FDM). All samples were subjected to the assessment of material properties. Thermal and thermomechanical properties were evaluated using differential scanning calorimetry analysis (DSC) and dynamic thermal mechanical analysis (DMTA). Mechanical characteristic was evaluated using static tensile and flexural measurements and Charpy impact resistance tests. The research was supplemented with scanning electron microscopy analysis (SEM). It was found that the addition of PBAT and TPS greatly improves impact strength and elongation, especially with the addition of reactive compatibilizer. As expected, TPS, PBAT, and BH reduced the stiffness of the composites during DMTA testing. The presence of BH particles in the polymer matrix was observed to improve the crystallization behavior of PLA. The optimal content of BH filler in the composite was found to be 10%, which allowed to preserve good mechanical properties.
High Spatial-Resolution Digital Phase-Stepping Shearography
Authors: Al Jabri Awatef Rashid , Abedin Kazi Monowar , Rahman Sheikh Mohammed Mujibur
Published: September 2021

Digital phase-stepping shearography is a speckle interferometric technique that uses laser speckles to generate the phase map of the displacement derivatives of a stressed object, and hence can map the stresses of a deformed object directly. Conventional digital phase-stepping shearography relies on the use of video cameras of relatively lower resolution, in the order of 5 megapixels or lower, operating at a video rate. In the present work, we propose a novel method of performing high spatial resolution phase stepping shearography. This method uses a 24 megapixel still digital imaging device (DSLR camera) and a Michelson-type shearing arrangement with an edge-clamped, center-loaded plate. Different phase-stepping algorithms were used, and all successfully generated shearograms. The system enabled extremely high-resolution phase maps to be generated from relatively large deformations applied to the test plate. Quantitative comparison of the maximum achieved spatial resolution is made with the video-rate cameras used in conventional shearography. By switching from conventional (video) imaging methods to still imaging methods, significantly higher spatial resolution (by about 5 times) can be achieved in actual phase-stepping shearography, which is of great usefulness in industrial non-destructive testing (NDT).
Interconnection between the Southern South China Sea and the Java Sea through the Karimata Strait
Authors: Kok Poh Heng , Wijeratne Sarath , Akhir Mohd Fadzil , Pattiaratchi Charitha , Roseli Nur Hidayah , Mohamad Ali Fariz Syafiq
Published: September 2021

This study aims to investigate the interconnection between the southern South China Sea (SSCS) and Java Sea (JS) by simulating seasonal circulations and associated transports using the Regional Ocean Modelling System (ROMS). The seasonal circulation was predominantly driven by monsoonal wind stress and water exchanges between the SSCS and the JS. During the boreal winter, cooler and saltier waters from the SSCS were advected into the JS, while during the boreal summer, cooler waters from the JS were advected into the SSCS, with the advection of fresher water onto the Peninsular Malaysia’s east coast in the SSCS being the new finding provided by this study. The various water transports were driven southward into the JS during the boreal winter and northward into the SSCS during the boreal summer. The various water transports estimated by ROMS peaked in May during the inflow months from the JS into the SSCS, which was attributed to the simulated anticyclonic eddy in the SSCS, which differed from previous studies that peaked between June and August. The annual mean volume, freshwater, heat, and salt transports were 0.96 Sv, 0.04 Sv, 0.10 PW, and 0.03 × 109 kg s−1, respectively, directed from the SSCS into the JS.
A New Scheme of Adaptive Covariance Inflation for Ensemble Filtering Data Assimilation
Authors: Su Ang , Zhang Liang , Zhang Xuefeng , Zhang Shaoqing , Liu Zhao , Liu Caili , Zhang Anmin
Published: September 2021

Due to the model and sampling errors of the finite ensemble, the background ensemble spread becomes small and the error covariance is underestimated during filtering for data assimilation. Because of the constraint of computational resources, it is difficult to use a large ensemble size to reduce sampling errors in high-dimensional real atmospheric and ocean models. Here, based on Bayesian theory, we explore a new spatially and temporally varying adaptive covariance inflation algorithm. To increase the statistical presentation of a finite background ensemble, the prior probability of inflation obeys the inverse chi-square distribution, and the likelihood function obeys the t distribution, which are used to obtain prior or posterior covariance inflation schemes. Different ensemble sizes are used to compare the assimilation quality with other inflation schemes within both the perfect and biased model frameworks. With two simple coupled models, we examined the performance of the new scheme. The results show that the new inflation scheme performed better than existing schemes in some cases, with more stability and fewer assimilation errors, especially when a small ensemble size was used in the biased model. Due to better computing performance and relaxed demand for computational resources, the new scheme has more potential applications in more comprehensive models for prediction initialization and reanalysis. In a word, the new inflation scheme performs well for a small ensemble size, and it may be more suitable for large-scale models.
A Novel Ship Collision Avoidance Awareness Approach for Cooperating Ships Using Multi-Agent Deep Reinforcement Learning
Authors: Chen Chen , Ma Feng , Xu Xiaobin , Chen Yuwang , Wang Jin
Published: September 2021

Ships are special machineries with large inertias and relatively weak driving forces. Simulating the manual operations of manipulating ships with artificial intelligence (AI) and machine learning techniques becomes more and more common, in which avoiding collisions in crowded waters may be the most challenging task. This research proposes a cooperative collision avoidance approach for multiple ships using a multi-agent deep reinforcement learning (MADRL) algorithm. Specifically, each ship is modeled as an individual agent, controlled by a Deep Q-Network (DQN) method and described by a dedicated ship motion model. Each agent observes the state of itself and other ships as well as the surrounding environment. Then, agents analyze the navigation situation and make motion decisions accordingly. In particular, specific reward function schemas are designed to simulate the degree of cooperation among agents. According to the International Regulations for Preventing Collisions at Sea (COLREGs), three typical scenarios of simulation, which are head-on, overtaking and crossing, are established to validate the proposed approach. With sufficient training of MADRL, the ship agents were capable of avoiding collisions through cooperation in narrow crowded waters. This method provides new insights for bionic modeling of ship operations, which is of important theoretical and practical significance.
Noise and Work Reduction through Remodeling of Stern Tube Assembly in a Shipbuilding Process by Applying TRIZ Theory
Authors: Wang Chia-Nan , Tibo Hector , You Chao-Jie
Published: September 2021

This study focuses on the installation of a stern tube which is one of the tasks in shafting installation. The traditional way to set up a stern tube needs more labor input in terms of manpower, work schedule and cost. Not only that, during processing, it requires large boring machinery which generates noise which is harmful to workers’ physical and mental conditions. This study first utilizes problem hierarchy analysis in redefining the problem before finding out the solutions using technical contradiction to work out the feasible solutions. Then, after refining and analyzing the feasible solutions, the feasible solutions were carried out and then an “integrated Stern Tube” was created, which decreased 49% of the cost and 71% of the work period in a dock. This means that the new technique makes it possible for a shipyard to enhance its capacity of building vessels as well as lower the noise effectively. As a result, these improvements add up to a friendlier working environment and lead to a win-win situation between workers and management.
The Response of Airborne Mycobiome to Dust Storms in the Eastern Mediterranean
Authors: Peng Xuefeng , Gat Daniela , Paytan Adina , Rudich Yinon
Published: September 2021

Airborne microbial communities directly impact the health of humans, animals, plants, and receiving ecosystems. While airborne bacterial and fungal communities have been studied by both cultivation-based methods and metabarcoding surveys targeting specific molecular markers, fewer studies have used shotgun metagenomics to study the airborne mycobiome. We analyzed the diversity and relative abundance of fungi in nine airborne metagenomes collected on clear days (“background”) and during dust storms in the Eastern Mediterranean. The negative correlation between the relative abundance of fungal reads and the concentrations of atmospheric particulate matter having an aerodynamic diameter smaller than 10 μm (PM10) indicate that dust storms lower the proportion of fungi in the airborne microbiome, possibly due to the lower relative abundance of fungi in the dust storm source regions and/or more effective transport of bacteria by the dust. Airborne fungal community composition was altered by the dust storms, particularly those originated from Syria, which was enriched with xerophilic fungi. We reconstructed a high-quality fungal metagenome-assembled genome (MAG) from the order Cladosporiales, which include fungi known to adapt to environmental extremes commonly faced by airborne microbes. The negative correlation between the relative abundance of Cladosporiales MAG and PM10 concentrations indicate that its origin is dominated by local sources and likely includes the indoor environments found in the city.
The Road from Money to Happiness
Authors: Mureșan Gabriela Mihaela , Fülöp Melinda Timea , Ciumaș Cristina
Published: September 2021

Nowadays, companies must be concerned with the levels of satisfaction and happiness of employees. Hence, this paper proposes to investigate the links between salary and happiness through an exploratory study with a quasi-experimental design. The sample included 376 respondents, and we employed structured equation modeling (SEM) in ADANCO. Prior to evaluating the structural model, the goodness of fit shows moderate/excellent values. Our empirical results show a positive relationship between salary and happiness, salary and life satisfaction, salary and financial satisfaction, financial satisfaction and life satisfaction, and financial satisfaction and happiness. Thus, we consider that our research contributes to the literature by analyzing the relationship between income and happiness in a developing country such as Romania. Congruent with previous findings, we consider that our results provide evidence of the road from salary to happiness in developing countries.
Spatiotemporal Patterns of the Use of Green Space by White-Collar Workers in Chinese Cities: A Study in Shenzhen
Authors: Xie Xiaohuan , Zhou Hanzhi , Gou Zhonghua , Yi Ming
Published: September 2021

White-collar workers, with tremendous work pressure, excessive working hours, and poor physical condition, need green spaces not only to have physical exercise and social gatherings, but also to become closer to nature and to relieve stress for their mental health. In China, the 996 office schedule, working from 09:00 to 17:00 six days a week, has become popular in the workplace; under such high-intensity work and pressure, white-collar workers have limited time to access green space for leisure, and their use of green space for health benefits is compromised. This study selected Shenzhen Futian Central Business District to find out the green space use patterns and preferences of white-collar workers based on GPS data and questionnaire surveys. In addition, the value of green exposure in the time dimension was calculated according to individuals’ actual behaviors. Based on cluster analysis, this study summarized the typical green space use patterns of three groups of white-collar workers, which reflects the hidden inequity of white-collar groups who are subjected to varying degrees of spatiotemporal constraints in using green space. This paper puts forward three directions for the optimization of green space allocation, functional facilities, and improved walkability in employment-intensive urban areas. The results provide certain guiding significance for alleviating the mismatch of time and space in green space enjoyment and for improving the spatiotemporal inclusiveness of green spaces in urban central business districts.
House Price Forecasting from Investment Perspectives
Authors: Shi Song , Mangioni Vince , Ge Xin Janet , Herath Shanaka , Rabhi Fethi , Ouysse Rachida
Published: September 2021

Housing market dynamics have primarily shifted from consumption- to investment-driven in many countries, including Australia. Building on investment theory, we investigated market dynamics by placing investment demand at the center using the error correction model (ECM). We found that house prices, rents, and interest rates are cointegrated in the long run under the present value investment framework. Other economic factors such as population growth, unemployment, migration, construction activities, and bank lending were also important determinants of the housing market dynamics. Our forecasting results show that the Sydney housing market will continue to grow with no significant price decline in the foreseeable future.
Land Use Optimization in a Resource-Exhausted City Based on Simulation of the F-E-W Nexus
Authors: Yu Xujing , Shan Liping , Wu Yuzhe
Published: September 2021

Limited land resources are used to meet the growing economic, social, and ecological needs of people in China. Food, energy, and water (F-E-W) are the basic resources for supporting human survival and the transformation of different land uses. This paper tries to construct a theoretical framework of land use and the F-E-W nexus and uses system dynamics to simulate the optimal allocation of land use in Shizuishan City, China, by comparing different scenarios that have different parameters related to F-E-W. The final results follow: (1) according to the relationship between land use and the F-E-W nexus, a three-layer nested theoretical framework is constructed. (2) Future land use under different scenarios differs. Under the scenarios of a less dependence on coal energy, a higher utilization efficiency of energy and agricultural water resources, and a lower grain self-sufficiency rate, there are less crop and urban lands but more ecological land. However, generally speaking, crop and rural construction lands tend to decrease, while urban and ecological lands tend to increase. (3) Combined with different objectives, the rapid transformation scenario is considered a better option in which to achieve a balance among the economy, society, and ecology. This paper also discusses the application of land use optimization in the delineation of three control lines in territory-space planning in China.
Farmland Zoning Integrating Agricultural Multi-Functional Supply, Demand and Relationships: A Case Study of the Hangzhou Metropolitan Area, China
Authors: He Shan , Lin Lin , Xu Qian , Hu Chenxia , Zhou Mengmeng , Liu Jinhua , Li Yongjun , Wang Ke
Published: September 2021

Land-use zoning provides an effective tool for designing and implementing differentiated farmland-protection policies. Despite the exponential increase in research on farmland zoning in recent years, little research has comprehensively explored the supply, demand and relationships of the diverse functions of farmland. In this study, multi-sourced datasets and diverse methods, along with GIS, were combined to spatially evaluate the supply, demand and relationship patterns among the production, ecological and landscape-cultural functions of the farmland of Hangzhou City in China, to construct farmland zoning. The results indicate that high production supply was mostly concentrated in flat plains, whereas highly ecological farmland was frequently observed in mountains. Both urban and rural areas had the capacity to provide aesthetics and recreation. Regarding demand, high values were mainly observed near the downtown area. Additionally, supply-and-demand matching (SDM) and multi-functional coupling and coordination degree (MCCD) were evaluated. Among the four basic zones acquired by SDM analysis, two zones dominated by more than one function were further divided into four sub-regions, according to the MCCD values. Ultimately, six farmland-use zones were determined. By considering the supply, demand and relationships of multiple functions, this farmland-zoning program offers new insights into differentiated farmland protection.
A Novel Real-Time RT-PCR-Based Methodology for the Preliminary Typing of SARS-CoV-2 Variants, Employing Non-Extendable LNA Oligonucleotides and Three Signature Mutations at the Spike Protein Receptor-Binding Domain
Authors: Chaintoutis Serafeim C. , Chassalevris Taxiarchis , Balaska Sofia , Mouchtaropoulou Evangelia , Tsiolas George , Vlatakis Ioannis , Tychala Areti , Koutsioulis Dimitris , Argiriou Anagnostis , Skoura Lemonia , Dovas Chrysostomos I.
Published: September 2021

Mutations resulting in amino-acid substitutions of the SARS-CoV-2 spike protein receptor-binding domain (RBD) have been associated with enhanced transmissibility and immune escape of the respective variants, namely Alpha, Beta, Gamma or Delta. Rapid identification of the aforementioned variants of concern and their discrimination of other variants is thus of importance for public health interventions. For this reason, a one-step real-time RT-PCR assay employing four locked nucleic acid (LNA) modified TaqMan probes was developed, to target signature mutations associated with amino-acid substitutions at positions 478, 484 and 501 present in the receptor-binding motif (RBM) of the spike protein RBD. This region contains most contacting residues of SARS-CoV-2 that bind to ACE2. A novel strategy employing the use of non-extendable LNA oligonucleotide blockers that can reduce non-specific hybridization of probes increased the number of different mutated sites examined in a multiplex PCR. The combinatory analysis of the different fluorescence signals obtained enabled the preliminary differentiation of SARS-CoV-2 variants of concern. The assay is sensitive with a LOD of 263 copies/reaction for the Delta variant, 170 copies/reaction for the Beta variant, amplification efficiencies > 91% and a linear range of >5 log10 copies/reaction against all targets. Validation of the assay using known SARS-CoV-2-positive and negative samples from humans and animals revealed its ability to correctly identify the targeted mutations and preliminary characterize the SARS-CoV-2 variants. The novel approach for mutation typing using LNA oligonucleotide blockers can be modified to target signature mutations at four different sites in the RBM and further expand the range of variants detected.
Reliability and Correlation of Different Devices for the Evaluation of Primary Implant Stability: An In Vitro Study
Authors: Raz Perry , Meir Haya , Levartovsky Shifra , Peleg Maia , Sebaoun Alon , Beitlitum Ilan
Published: September 2021

Our aim was to analyze the correlation between the IT evaluated by a surgical motor and the primary implant stability (ISQ) measured by two RFA devices, Osstell and Penguin, in an in vitro model. This study examines the effect of bone type (soft or dense), implant length (13 mm or 8 mm), and implant design (CC: conical connection; IH: internal hexagon), on this correlation. Ninety-six implants were inserted using a surgical motor (IT) into two types of synthetic foam blocks. Initial measurements for both the peak IT and ISQ were recorded at the point when implant insertion was stopped by the surgical motor, and the final measurements were recorded when the implant was completely inserted into the synthetic blocks using only the RFA devices. Our null hypothesis was that there is a good correlation between the devices, independent of the implant length, design, or bone type. We found a positive, significant correlation between the IT, and the Osstell and Penguin devices. Implant length and bone type did not affect this correlation. The correlation between the devices in the CC design was maintained; however, in the IH design it was maintained only between the RFA devices. We concluded that there is a high positive correlation between the IT and ISQ from a mechanical perspective, which was not affected by bone type or implant length but was affected by the implant design.
2D Organic–Inorganic Hybrid Perovskite Quantum Well Materials and Their Dramatical X-ray Optoelectronic Properties
Authors: Chen Huiwen , Li Yunlong , Xue Dongfeng
Published: September 2021

Two-dimensional organic–inorganic hybrid perovskites (2D OIHPs) have attracted extensive attention in the field of X-ray detection due to their excellent stability compared to traditional three-dimensional OIHPs and the strong optoelectronic response to X-ray along the quantum wells. In this review, the nucleation and growth process as well as intermolecular forces for controlling out-of-plane growth are summarized along with the oriented growth mechanism. The optoelectronic properties in 2D OIHP under irradiation of X-ray are also discussed. Finally, conclusions and outlook for orientation 2D OIHP quantum wells and their challenges in application of direct X-ray detection are given. This review will provide a basic understanding on the strategy of designing 2D OIHP thick films as promising X-ray photoconductors, which may inspire the development of next-generation X-ray detectors.
Helical Nanostructures of Ferroelectric Liquid Crystals as Fast Phase Retarders for Spectral Information Extraction Devices: A Comparison with the Nematic Liquid Crystal Phase Retarders
Authors: AbuLeil Marwan J. , Pasha Doron , August Isaac , Pozhidaev Evgeny P. , Barbashov Vadim A. , Tkachenko Timofey P. , Kuznetsov Artemy V. , Abdulhalim Ibrahim
Published: September 2021

Extraction of spectral information using liquid crystal (LC) retarders has recently become a topic of great interest because of its importance for creating hyper- and multispectral images in a compact and inexpensive way. However, this method of hyperspectral imaging requires thick LC-layer retarders (50 µm–100 µm and above) to obtain spectral modulation signals for reliable signal reconstruction. This makes the device extremely slow in the case of nematic LCs (NLCs), since the response time of NLCs increases proportionally to the square of the LC-layer thickness, which excludes fast dynamic processes monitoring. In this paper, we explore two approaches for solving the speed problem: the first is based on the use of faster nanospiral ferroelectric liquid crystals as an alternative to NLCs, and the second is based on using a passive multiband filter and focuses on multispectral extraction rather than hyperspectral. A detailed comparative study of nematic and ferroelectric devices is presented. The study is carried out using a 9-spectral bands passive spectral filter, covering the visible and near-infrared ranges. We propose the concept of multispectral rather than hyperspectral extraction, where a small number of wavelengths are sufficient for specific applications.
Rapid Evaluation of the Pozzolanic Activity of Bayer Red Mud by a Polymerization Degree Method: Correlations with Alkali Dissolution of (Si+Al) and Strength
Authors: Wang Yaguang , Liu Xiaoming , Xie Zhiqing , Wang Huimin , Zhang Wei , Xue Yang
Published: September 2021

A large amount of Bayer process red mud is discharged in the process of alumina production, which has caused significant pollution in the environment. The pozzolanic activity of Bayer red mud as a supplementary cementitious material is a research hotspot. In this work, a new method for Fourier-transform infrared spectrometry is used to determine the polymerization degree of Bayer red mud in order to evaluate its pozzolanic activity. Based on the results of the dissolution concentration of (Si+Al), strength index and polymerization degree of Bayer red mud, the relationships between different evaluation methods were analyzed, and the relevant calculation formulas of pozzolanic activity were obtained. The results showed that different evaluation methods can reflect the variation law of pozzolanic activity in Bayer red mud. The polymerization degree of Bayer red mud had a good linear relationship with the pozzolanic activity index obtained by the strength index and dissolution concentration of (Si+Al), respectively. The polymerization degree was negatively correlated with pozzolanic activity index and dissolution concentration of (Si+Al), and the correlation coefficients were greater than 0.85. Therefore, this method was found to be effective and hence can be used as a rapid and simple test for pozzolanic activity evaluation of Bayer red mud.