bluuebunny/crossref_metadata_2025 huggingface dataset:
MS. 4. Yüzyılda Atina’da Eğitim ve Kappadokialı Ioulianus
Authors: Kaşka Gülcan
Published: October 2024

Atina’da eğitim özellikle MÖ. 5-4. yüzyıllarda büyük gelişme kaydetmiş ve bu itibaren Atina kurulmuş olan okullar sayesinde büyük bir üne kavuşmuştur. Bu ünü çağlar boyu sürdüren kent, MS. sonraki yüzyıllarda da eğitim alanında Akdeniz dünyasında çok önemli bir yere sahip olmuştur. Birçok entelektüeli yetiştiren Atina, MS. 4. yüzyılda okullarıyla halen Akdeniz’in en gözde kenti olma özelliğini sürdürmüştür. Ancak, bu dönemin en önemli özelliği olarak öğrenciler arasında vuku bulan kavgalar göze çarpmaktadır. MS. 4. yüzyılda öğretmenlerine bağlılıklarını yansıtan öğrenci grupları arasında cereyan eden bu çatışmalar antik dönem yazarları tarafından sıklıkla anlatılmıştır. Bu makalede bu dönemdeki eğitim anlayışı, Eunapios’un Filozoflar ve Sofistlerin Hayatı adlı eserinin Kappadokialı Ioulianus kısmı çevrilerek irdelenmiştir.
Development of an Evaluation Instrument on Artificial Intelligence Search Tools for Evidence Synthesis
Authors: CDA-AMC
Published: October 2024

What Was the Question?
There are conflicting calls for evidence synthesis producers to adopt or avoid recent Artificial Intelligence (AI) technologies. Our question was: How do we evaluate rapidly evolving AI tools to enhance the production of evidence syntheses and maintain quality standards?
What Did We Do?
To advance information retrieval science for producing evidence syntheses at Canada’s Drug Agency (CDA-AMC), the Research Information Services team developed a process to evaluate promising AI search tools. We inventoried 51 tools in the fall of 2023, established selection criteria, assessed specific attributes, and built a standalone instrument to support continuous monitoring and evaluation of new tools.
What Did We Find?
Rapid development of AI search tools requires a flexible evaluation instrument to inform adoption decisions and enable comparison between tools. We identified mandatory and desirable characteristics for suitable AI tools to assist with information retrieval tasks conducted by CDA-AMC. This work enabled the development of a flexible instrument to evaluate novel AI search tools for evidence synthesis.
What Does This Mean?
CDA-AMC operationalized a replicable process to monitor and evaluate AI search tools. Our approach to evaluating AI technologies will advance information retrieval methods by CDA-AMC, and our evaluation instrument will assist any evidence synthesis producer interested in adopting AI search tools.
Development of an Evaluation Instrument on Artificial Intelligence Search Tools for Evidence Synthesis
Authors: Mittmann Nicole
Published: October 2024

Canada’s Drug Agency has developed an instrument to monitor and evaluate artificial intelligence tools for information retrieval so that, as these tools evolve, we can leverage them appropriately.
We are sharing our instrument to help other evidence synthesis producers evaluate and make use of artificial intelligence tools for information retrieval.
Desafios e estratégias para segurança alimentar mundial
Authors: Shinohara Neide Kazue Sakugawa
Published: October 2024

A preocupação quanto à Segurança Alimentar (Food Security) surgiu decorrente das sequelas da Segunda Guerra Mundial, causando flagelos humanos e impactos devastadores no meio ambiente. Os países envolvidos nesse conflito de escala global ficaram sem condições de produzir alimentos para abastecer as populações, o que gerou grande desordem social e econômica. Esse momento avassalador na história humana trouxe a conscientização universal que a garantia na oferta de alimentos e água potável para a população mundial, ajudaria na busca da paz e harmonia entre as nações de diferentes etnias, culturas e poder econômico. Diante de constantes desafios para garantir uma vida digna para as populações, a Organização das Nações Unidas (ONU) e países membros, adotaram em 2015 os Objetivos de Desenvolvimento Sustentável (ODS), plano de ação que compreende 17 Objetivos Globais. Os ODS estão baseados em 5 princípios orientadores: Pessoas, Planeta, Prosperidade, Paz e Parcerias. Foi uma chamada universal para mitigar a pobreza, proteger o planeta e garantir que até 2030 todas as pessoas desfrutem de paz, prosperidade econômica e justiça social. Infelizmente, grande parte da população global ainda tem consumo abaixo das necessidades nutricionais, devido às dificuldades de acesso, falta de recursos financeiros, deficiência no acesso a tecnologias eficientes e práticas resilientes. Ações essas que levaria a uma economia mais eficaz desde a produção até o gerenciamento dos alimentos, repercutindo no combate a insegurança alimentar.
تحسين أداء العملي ة الإنتاجية باستخدام منهجية الستة سيجما حالة دراسية بالشركة الليبية للحدي د والصل ب
Authors: درميش أميرة , شنب عمر , الأمين فتحي , أبوقديدة رمضان
Published: October 2024

لم يعد الالتزام بمواصفات المنتجات الصناعية كافيا في الوقت الحالي مع التنافس الكبير في الأسواق، ولقد أصبح من الضروري لتحقيق متطلبات العميل استخدام أساليب تحسين الجودة الأكثر تطوراً. تكمن مشكلة الدراسة في سعى الشركة الليبية للحديد والصلب للتحسين المستمر لمنتجاتها من ناحية الجودة ووقت التصنيع والانتظار، وكذلك خفض التكاليف وزيادة الإنتاجية لكسب ثقة المستهلك، ولتحقيق هذه المتطلبات، يجب عليها استخدام التقنيات الحديثة لقياس الجودة. وعليه فإن هذا البحث يهدف إلى دراسة إمكانية تطبيق منهجية الستة سيجما في الشركة الليبية للحديد والصلب، والتعرف على الفوائد الناتجة عن تطبيقها، والمعوقات التي ترافق عملية التطبيق.  تمت دراسة الحالة بمصنع درفلة القضبان لمعرفة سير العملية الإنتاجية وكمية الإنتاج والكشف عن القطع المعيبة، ومعرفة أسباب حدوث المعيب، والخفض من هذه الأسباب وتحسين جودة المنتجات. وقد تم ذلك عن طريق تشكيل فريق لتحديد أهم الخواص الميكانيكية التي تم قياسها (إجهاد الخضوع، قوة الشد والاستطالة)، وتحديد عدد العينات، وحجمها، وقد تم جمع بيانات العينات من المعمل الخاص بمصنع الدرفلة وتحليلها بالبرنامج الإحصائيMinitab  ورسم لوحات المتوسط والمدى وتحليل مقدرة العملية الإنتاجية، وحساب مستوى الستة سيجما عن طريق معادلة .DPMO ومن خلال هذه الدراسة تم التوصل إلى أن أغلب القطع المعيبة كان سببها انخفاض في إجهاد الخضوع بسبب انخفاض نسبة الكربون. وكذلك فإنه من الضروري تحسين عملية التبريد المائي والكشف الدوري عليها. وتوصلت الدراسة لضرورة تنفيذ برامج تدريبية لتأهيل العاملين وتدريبهم على تقنيات وأدوات الستة سيجما، وكذلك توفير جميع متطلبات التطبيق والنجاح لمنهجية الستة سيجما.
The Effects of Ubiquinone on the Antioxidant System in Male Rats Exposed to Saccharin-Induced the Hepatic Toxicity
Authors: Aboukhezam Barga , Ahmed F. A.
Published: October 2024

Saccharin (Sac) is a widely used artificial sweetener with significant applications in the food industry, pharmaceutical formulations, and tobacco products. Despite its popularity, saccharin has drawn attention due to its potential carcinogenic effects and associations with various health risks, including renal impairment, hepatic dysfunction, obesity, and diabetes. This study aimed to investigate the protective effects of Ubiquinone, or coenzyme Q10 (COQ10), on liver toxicity induced by saccharin, focusing on oxidative stress and antioxidant markers. In this experiment, rats were divided into six groups of ten. The control group received no treatment, while the second group was administered COQ10 at a dosage of 20 mg per kilogram of body weight. The third and fourth groups were given saccharin at 1/10 and 1/20 of the lethal dose 50 (LD50), respectively. The fifth and sixth groups received saccharin at the same dosages as the third and fourth groups, but with additional COQ10 supplementation. All treatments were administered orally for 30 days, after which liver tissues were collected to assess oxidative stress and antioxidant markers. The results revealed that saccharin significantly increased oxidative stress in the liver, as evidenced by elevated levels of malondialdehyde (MDA) and oxidized glutathione (GSSG). Additionally, saccharin-treated groups exhibited a marked decrease in antioxidant markers, including reduced glutathione (GSH) and superoxide dismutase (SOD). However, the groups that received COQ10 alongside saccharin showed significant improvement, with oxidative stress and antioxidant levels nearly returning to those observed in the control group. These findings suggest that saccharin consumption promotes the generation of reactive oxygen species and contributes to liver damage, characterized by necrotic hepatocytes, sinusoidal dilatation, and inflammatory infiltration. The protective effects of COQ10 in mitigating saccharin-induced oxidative stress highlight its potential as a therapeutic agent for preventing liver damage associated with saccharin intake.
Os Direitos Humanos e a inclusão de estudantes imigrantes no espaço escolar
Authors: Pereira Juliane Edineia Rodrigues Ferreira Richeski , Schimanski Edina
Published: October 2024

O aumento do fluxo de estudantes imigrantes no espaço escolar faz repensar a inclusão da interculturalidade e cidadania global. Para isso, a escola é a porta de entrada de mosaicos culturais, a presença de estudantes de várias nacionalidades demanda reconhecimento, integração, oportunidade e igualdade de direitos à educação. Os professores são agentes de mudança embasados na garantia de educação para todos conforme lista na Constituição brasileira e respeito a dignidade humana dos Direitos humanos, este artigo baseou-se na pesquisa bibliográfica sobre a dimensão histórica, sociocultural e política de sistemas educacionais inclusivos, além de documentos inclusivos no âmbito internacional. Objetiva-se demonstrar que os estudantes imigrantes estão respaldados nos marcos legais e que merecem ser incluídos com garantias iguais na educação
Inclusão de alunos com deficiência no ensino superior brasileiro: análise crítica das práticas educativas e políticas de inclusão
Authors: Lima Lucelia Mateus , Manjinski Everson
Published: October 2024

Com o propósito refletir sobre a efetivação da inclusão de alunos com deficiência ingressos no ensino superior, o presente artigo traz reflexões a certa da educação inclusiva no âmbito das práticas pedagógicas. Diante do novo paradigma da educação inclusiva, que exige das instituições de ensino superior apoio as políticas educacionais, é imprescindível que essas instituições implementem práticas inclusivas no ambiente universitário. O objetivo geral da pesquisa é discutir sobre as implicações existentes no processo inclusivo, visando uma educação de excelência que contribua para o processo educacional da pessoa com deficiência. Como objetivos específicos, buscamos analisar a política de educação inclusiva, compreender a realidade do processo inclusivo dentro das universidades, e refletir sobre as ações existentes com vistas à efetivação de práticas significativas para a formação profissional dos acadêmicos. Para alcançar esses objetivos, foi realizada uma pesquisa bibliográfica, revisando e analisando estudos e documentos relevantes sobre educação inclusiva, práticas pedagógicas e políticas educacionais. Os estudos em andamento mostram que, apesar dos progressos nas políticas de inclusão, ainda existem lacunas significativas na implementação efetiva destas políticas nas universidades. As barreiras físicas e comportamentais e a falta de recursos adequados apontam como um dos principais desafios. As implicações práticas deste estudo apontam a necessidade urgente de capacitação contínua de professores, além do desenvolvimento de infraestruturas acessíveis e recursos pedagógicos adaptados. A relevância deste estudo para o campo da Educação Inclusiva está na contribuição para a conscientização e promoção de práticas educacionais que realmente atendam às necessidades dos alunos com deficiência, fomentando uma cultura de inclusão e equidade no ensino superior.
Desafios na implementação da educação inclusiva em Moçambique: uma análise crítica
Authors: Choveque Ismael Xavier , Manjinski Everson
Published: October 2024

Educação inclusiva em Moçambique, é um pacote novo na sua implementação. O objectivo deste estudo é avaliar os desafios na implementação da educação inclusiva em Moçambique, a pesquisa é de natureza qualitativa, baseou-se em revisões bibliográficas onde foi recorrido os autores como: Chambal (2011); Soniva (2022); Rogalski (2010); Favero et al (2009); Frias e Menezes (2009); Nguenha (2018); Cruz (2012) e nas experiencias profissionais enquanto professor. Por meio da análise dos escritos destes e ademais autores, os resultados mostram a não formação ou capacitação de professores na área específica para atender a qualquer tipo de criança com deficiência, as infra-estruturas inadequadas e falta de materiais didácticos, são os desafios pontuais na implementação da educação em Moçambique. Concluiu-se que o Ministério de Educação deve introduzir a disciplina de necessidades educativas especiais em todas instituições de formação, apostando na formação de professores, a reconstrução ou construção das infra estruturas devem ser feitas para garantir o acesso de quaisquer diferenças das crianças, e equipa-las didacticamente para que o acesso a aulas seja inclusivo. Para tal o governo deve por em prática e criar mais politicas, estratégias para que responda efectivamente a demanda do direito a educação e garantindo uma educação inclusiva, quantitativa e de qualidade para todos.
Theoretical justification for the layout of an industrial complex for the content of Blaptica dubia for the purpose of obtaining feed and food products
Authors: Aleksandrov V. V. , Shakirov S. R. , Khomenko R. M.
Published: October 2024

It is predicted that by 2050, up to 15% of proteins will be produced by insects [1; 6; 7]. Fats and enzymes, as well as chitinous coatings, ingredients currently widely used in cosmetology and the chemical industry, are valuable by-products [3]. The advantages of enterprises aimed at using insects as productive animals are lower expenditure on feed, insects have a more flexible digestive system and highly active enzymes, which allows them to obtain maximum energy and nutrients even from not the highest quality feed [5]. The Argentine cockroach is superior to other productive insects in many respects, which may make it the most promising species for the development of industrial entomology.
Hygiene of deer keeping
Authors: Podluzhnov A. V. , Belopolsky A. E.
Published: October 2024

Deer can hardly be called agricultural, much less domestic animals, but the history of keeping and breeding these amazing animals is very peculiar and time-consuming. In the countries of Northern Europe, rock carvings depicting deer in a stall or enclosing structures, which are about 5,000 years old, are still found. Since ancient times, deer have been hunted both for meat and for entertainment, in Western European countries the deer was a "royal" trophy available only to aristocrats, but in extreme cases (for example, in case of war) deer meat saved people from starvation. In peacetime, the ban on hunting for commoners maintained the number of these animals in the wild at a certain constant level, most red deer and fallow deer lived in park areas, in fact, representing the prototype of a modern deer farm. Deer were also kept in farms, menageries, nature reserves, and since the middle of the 20th century, modern deer farms have become widespread. According to statistics from the European Reindeer Herders Association FEDFA, there were 75,150 owners of red deer and 204,550 owners of fallow deer. So, only in modern Britain there are about 300 reindeer herding farms, where the deer is already considered quite a familiar, agricultural animal.
Anatomy of the uterus of sheep of the Edilbaev breed in the age aspect
Authors: Shchipakin M. V. , Melnikov S. I.
Published: October 2024

Sheep farming is one of the key branches of animal husbandry in the Russian Federation. Various measures aimed at further increasing the useful qualities in sheep breeding are based not only on breeding principles, but also on the achievements of veterinary sciences. It is quite understandable that the special attention of biological science and agricultural practice to the breed, age, and species characteristics of animals, namely to the reproduction system, allows us to scientifically and correctly raise issues in breeding, care, feeding, exploitation and reproduction. Not knowing the issues of anatomical topography, the structure of organs in animals of different age groups, it is difficult to carry out various medical manipulations in surgical or obstetric and gynecological practice. The study was conducted at the Department of Animal Anatomy of the St. Petersburg State University of Veterinary Medicine. Cadaveric material for the study was delivered to the Department of Animal Anatomy of the St. Petersburg State University of Veterinary Medicine from a farm in the Leningrad Region. Female sheep of the Edilbaev breed served as the object of the study. Three age groups were selected for the study. The study established the anatomical features of the uterus in the age aspect in sheep of the Edilbaev breed, and morphometric measurements were carried out in three age-related physiological groups (fetuses, newborns, young). Skeleto- and syntopia of all parts of the uterus was determined in different age groups. It was established that the uterus of sheep of the Edilbaevsky breed belongs to mobile organs, that is, depending on physiological conditions, it can change its topographic location points. Morphometry has determined that there is an uneven increase in the components of all parts of the uterus from the fetal period to the age stage of the young. The results of the study can be used by veterinary specialists, in particular obstetricians, surgeons to establish operative access to the uterus and in obstetric and gynecological practice in sheep breeding.
Hunting resources as an object of legal regulation
Authors: Chekhovskikh I. A. , Ol E. M.
Published: October 2024

Hunting resources are a special object of legal regulation, in relation to which a specific regime for their protection and use can be established. The current legislation provides for differentiation of requirements in relation to hunting resources, in relation to which a prohibition or permit regime is introduced.

The article provides the main examples of establishing appropriate permits or prohibitions related to the extraction of hunting resources, which accordingly form the legal regime for the use and protection of wildlife.
Evaluation of the efficacy of inhalation application of bacteriophage preparations in bronchopneumonia associated with Klebsiella pneumoniae
Authors: Kiyanchuk M. V. , Sukhinin A. A.
Published: October 2024

Against the background of increasing antibiotic resistance among pathogens of bovine bronchopneumonia, interest in phagotherapy as a therapeutic tool is revived. Inhaled phagotherapy in turn has the potential to change the treatment regimen for bacterial respiratory infections, including those caused by antibiotic-resistant bacteria. Inhaled drug delivery tools allow the delivery of bacteriophages directly to the lesion. An important advantage, especially when it comes to bacteriophages, is the ability to use smaller doses of drugs than would be required if another route of administration were chosen. The article presents the results of evaluating the efficacy of the inhalation method of administration of commercial bacteriophage preparations in a mouse model. Mice were divided into five groups (1,2-animals exposed to Klebsiella pneumonia infection and undergoing bacteriophage inhalation (n=6), 3-animals exposed to infection and not undergoing therapy (n=3), 4- control group of animals not exposed to infection (n=3)). Inhalations were performed using a compressor four-mode Neb-Aid inhaler (Flaem Nuova, Italy). Rapidflyam 2 nebuliser was used in mode I (particle size 0.8-2.0 μm). The results demonstrate the effectiveness of the developed therapy scheme, which allows further use of bactriophage-containing preparations in infectious diseases of animals.
Caseous lymphadenitis in sheep and goats semiotics and the experience of struggle
Authors: Pimenov N. V. , Almuslimavi H. A. , Ivannikova R. F.
Published: October 2024

Based on the analysis of the research experience of various scientists in recent years, this article describes both the characteristic and non-specific pattern of the manifestation of caseous lymphadenitis, possible methods of combating epizootics, including through active immunization of animals. Existing data do not sufficiently disclose the pathogenesis and can be used for preliminary diagnosis, and control methods developed during many years of research and testing do not always effectively solve the problem of epizootics, which is due, among other things, to the lack of vaccines.
The role of Testosterone in male reproductive system (review)
Authors: Maksimova M. A. , Korochkina E. A.
Published: October 2024

Testosterone is a hormone that is predominantly formed in Leydig cells adjacent to the seminal tubules of the testis, in the ovaries and adrenal cortex [1, 5, 6]. Testosterone production is regulated by the hypothalamic-pituitary system under the guidance of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH), between which there is negative feedback [5-6]. In addition to GnRH and LH, testosterone is also interconnected with other hormones: melatonin [14], oxytocin [15], thyroid hormones [16]. Testosterone has a great effect on the body of animals. Thus, it promotes the growth and maturation of bone tissue [17], prevents oxidative damage to the brain [19-20], affects metabolism [21], as well as animal behavior [23]. In addition, studies have noted the important role of the hormone in spermatogenesis. Testosterone, binding to the androgen receptor, regulates the proliferation and maturation of Sertoli cells, maintains the integrity of the blood-brain barrier, regulates the meiotic and post-meiotic processes of germ cells [27-30]. The effect of the hormone on sperm cryoresistance is noted, however, some authors emphasize the negative effect of testosterone on cryoresistance [32- 33], while others point to a beneficial effect [34]. In females, testosterone, together with other androgens, binds to androgen receptors, changes the activity of other receptors, and also interacts with growth factors [36]. Studies show that the hormone, together with LH, is able to stimulate the production of progesterone [37]. It is known that many factors influence the dynamics of testosterone in the blood. For example, with the passage of age, androgens in the blood decrease in bulls [41], however, in adult rams, the testosterone content is 1.8 times higher than in younger individuals [43]. Another factor worth noting is animal feeding: studies show that a diet with a higher protein content contributes to a positive effect on animals, as well as increases hormone levels [44-45]. In addition, heat stress suppresses the expression of enzymes involved in testosterone synthesis [47].
The effect of probiotics, prebiotics and synbiotics on the restoration of the clinical state and balance of the intestinal microbiome after antibiotic therapy
Authors: Katargin R. S. , Prusakov A. V. , Golodyaeva M. S.
Published: October 2024

The aim of the study was to establish the degree of influence of probiotics, prebiotics and synbiotics on the restoration of the clinical condition and balance of the intestinal microbiome of animals after antibiotic therapy.

We studied 20 cats of different ages who underwent antibacterial therapy using the drug Ceftriaxone at a dose of 20.0 mg per kg of body weight 2 times a day, in the form of intramuscular injections, divided into four groups, each of which included five animals.

The animals of the first group were prescribed the probiotic "Subtilis". The latter was administered orally in a dose of 8 drops, for 14 days. Animals of the second group were prescribed the probiotic "Subtilis" at the same dose and with the same multiplicity, as well as the prebiotic "Vetelact" in addition to it, at the rate of 0.1 ml per 1.0 kg of body weight daily for 14 days. The animals of the third group were administered orally the synbiotic "Evitalia-Vet" 1 tablet for 14 days. The fourth group was a control group. The animals included in it were under observation and did not receive any drugs.

It was found that the restoration of the clinical state and balance of the intestinal microbiome after antibiotic therapy was most intensive in animals receiving the probiotic "Subtilis" and the prebiotic "Vetelact". Under the influence of these drugs, at the end of treatment, the level of hemoglobin, erythrocytes and hematocrit decreased by 22.0%, 19.0% and 15.7%, respectively, in animals receiving them, compared with the indicators before it began. Also, in comparison with other groups, animals receiving the probiotic "Subtilis" and the prebiotic "Vetelact" showed a more pronounced decrease in the level of urea and total protein in blood serum, while the number of lactobacilli at the end of treatment was 42.0% higher, and the population of E. coli decreased by 37.0%, in comparison with control.

Thus, the simultaneous administration of probiotics and prebiotics to animals after undergoing antibiotic therapy gives the most effective result, manifested in the accelerated restoration of their clinical condition and the balance of the intestinal microbiome.
Use of immunotropic drugs in wound processes in different species of animals
Authors: Stekolnikov A. A. , Reshetnyak V. V. , Burdeyny V. V. , Malakhova V. V. , Iskaliev E. A. , Elokhin M. D.
Published: October 2024

In conditions of intensification of livestock farming, urbanization of society, accompanied by an increase in the number of productive and small domestic animals, changes in the conditions of their keeping, feeding, and exploitation, the number of non-communicable diseases is significantly increasing. Surgical diseases occupy a special place among them. In addition to accidental wounds, in some cases they are technologically widespread, especially in pig farming - castration, tail trimming, etc., accompanied by various kinds of complications.

Classic measures of their treatment quite often do not give the expected effect, but due to the fact that any damage, including surgical damage, leads to the development of an immunodeficiency state.

In such cases, the use of new techniques based on the use of immunotropic drugs is promising.

It has been shown that the effectiveness of the wound-healing effect of thymogen and ribav is determined by the size of the defect, before or after the start of bioregulatory therapy, and treatment methods.

It has been established that for wounds complicated by a fracture of the femur in outbred rats, the use of 5-day. A course of thymogen against the background of the use of kollapan-L causes more pronounced osteogenesis and ensures the formation of a more mature callus on the 45th day than in the control.

Damage to the hooves of moose breeding stock reaches a 30% level. The main reason for this, in contrast to wild livestock, is the violation of housing and feeding. The inclusion of thymogen in complex therapy helps restore the clinical status of animals, as well as reduce the inflammatory reaction, endogenous and bacterial intoxication, and increase adaptive reactions, as evidenced by the dynamics of integral leukocyte indices.

Application 5 days course of thymogen starting immediately after castration 5 months. boars in combination with etiotropic drugs helped to reduce the intensity of local reactions, the number of postoperative complications by four times, increased safety by 14.29%, average daily gains in live weight, and the production of meat products compared to the control of the highest category, in terms of cost when sold. The use of ribav was also effective, but less technologically advanced for mass processing of livestock.
Extraction of teeth in dogs
Authors: Ladanova M. A. , Kraskova E. V.
Published: October 2024

The article is devoted to the problems with the dental apparatus, indications and techniques of tooth extraction in dogs. Tooth extraction is an operative intervention in which the gum and periodontal tissues are separated in order to extract a tooth or root from the alveolar well. Various dental pathologies in dogs are very common. Dentistry has recently become a popular specialty among veterinary specialists. Mostly owners go to the veterinary clinic with complaints about the presence of an unpleasant odor from the oral cavity of their pet. It is much rare for owners to notice soreness in the animal during feed consumption, hypersalivation, the presence of blood and pus impurities, and a violation of jaw closure. There are certain indications for tooth extraction, which are divided into urgent and planned. Indications for urgent extraction include tooth mobility with an acute pain reaction, inability to take food, periapical abscess, etc. The planned tooth extraction includes: temporary teeth, teeth that injure soft tissues, dental pathologies that are not amenable to therapy, the presence of granulomas, cysts, and tumors on the roots of the tooth.
Evaluation of the radiographic picture in the area of a bone defect filled with osteoplastic material based on hydroxyapatite
Authors: Chernigova S. V. , Savidi V. O.
Published: October 2024

Reparative regeneration of bone tissue occurs by activating complex biological processes. In some cases, there is a need to stimulate these processes using biomaterials. One of the suitable biomaterials that has a stimulating effect on osteogenesis is hydroxypatite doped with silicate ions (silicate-substituted hydroxyapatite). Analogues of this biomaterial are used to replace bone tissue in clinical practice and show relatively high efficiency of use, which makes it possible to improve the structure by introducing various components into it. Thus, the osteoplastic material we proposed is being studied for the efficiency of use and evaluation of stimulation of reparative regeneration. Preclinical study was conducted on the basis of the Institute of Biomedical and Biological Sciences of the Omsk State Agrarian University named after P.A. Stolypin. In vivo studies were conducted using granules of silicate-substituted hydroxyapatite in a ratio of 50/50 to wollastonite with a diameter of 0.5 mm. The objects of the study were laboratory rabbits with models of bone defects performed in the form of an induced fracture of the proximal third of the tibia diaphysis with subsequent fixation by transosseous introduction of pins. Groups of animals were formed: experimental with the introduction of silicate-substituted hydroxyapatite granules into the defect cavity and control without defect replenishment. To assess the course of reparative regeneration and osteogenesis, an X-ray examination was performed on the 7th and 21st days, and an assessment of the clinical condition of the animals was carried out for 30 days. According to the X-ray images obtained on the 7th day, the following changes were revealed: the experimental group of animals showed signs of new bone tissue formation, as well as full contact of the defect cavity with the studied osteoplastic material, while in animals from the control group, clearly defined edges of the defect zone are visualized without signs of bone regenerate formation. Repeated X-ray examination on the 21st day showed pronounced signs of bone callus formation in the experimental group, while in the control group the regeneration process was slower, the formation of bone regenerate was less pronounced, and initial signs of fibrocartilaginous bone callus formation were noted. The data obtained during the study suggest that silicate-substituted hydroxyapatite has a stimulating effect on reparative regeneration and requires further study.
Clinical use of mesenchymal stromal cells in horses with orthopedic disease
Authors: Chernigova S. V. , Suchkov M. V. , Zakharova A. V. , Plyushchii I. V. , Zubkova N. V.
Published: October 2024

The development of a method for the treatment of orthopedic diseases of horses using stem cells, in particular allogeneic mesenchymal stromal cells, is an urgent scientific and applied task of veterinary medicine. The widespread use of tissue engineering technologies is limited by the lack of extensive clinical studies that would confirm the effectiveness and safety of this therapy. The aim of the study was to determine the therapeutic efficacy of parenteral administration of allogeneic mesenchymal stromal cells to horses in orthopedic diseases. The study involved 4 horses with desmitis of the suspensory ligament (interosseous third muscle). Mesenchymal stromal cells isolated from donor adipose tissue were injected into the area of damage to the suspensory ligament twice with an interval of 14 days at a dose of 2x106 cells suspended in 2-15 ml of 0.9% sodium chloride solution. Injections did not cause the development of inflammatory reactions. According to the results of the study, all horses returned to full training on average 3.2 ± 0.01 months after the start of therapy.
Pharmacokinetics of the drug Amoxyantar in pigs
Authors: Engashev S. V. , Komarov A. A. , Lunegov A. M. , Khlebalina A. S.
Published: October 2024

The article presents the results of pharmacokinetic studies of the drug Amoxiyantar in pigs. The results obtained indicate that amoxicillin is distributed throughout the tissues of animals, providing therapeutic concentrations in the studied dosage, ensuring effective distribution in the organs and tissues of the body of pigs, and also confirm the bioavailability of succinic acid with a high concentration in the blood plasma for an average of two hours. Based on the results of determining the dynamics of excretion of residual amounts of amoxicillin, it was detected in only one animal in the kidneys at a concentration of 54.9 μg/kg and in muscle tissue at a concentration of 25.2 μg/kg. In the remaining tissue samples of pigs obtained two days after application of the drug, as well as in all tissue samples of pigs obtained from the sixth day to the 18th day after application of the drug, amoxicillin was not detected.
Противоречие интерпретаций политического стереотипа железного занавеса в коллективной памяти (на примере студенческой молодёжи г. Тольятти)
Authors: Цветкова Ирина Викторовна
Published: October 2024

История советского периода на современном этапе является ареной политического противоборства. Это находит отражение в существовании противоречий в трактовках событий и явлений советской эпохи. Цель исследования – выявить противоречие интерпретаций политического стереотипа железного занавеса, которое находит проявление в суждениях молодежи о советском периоде истории и о современном обществе. Методология исследования базируется на концепциях конструктивизма, применяемых для изучения коллективной памяти. Эмпирическая база исследования включает материалы четырех фокус-групп, которые были проведены среди студентов трех вузов Тольятти. Результаты исследования показали, что противоречие интерпретаций железного занавеса проявляется в оценках молодежью идеологии, культуры советского периода. В отношении молодежи к поколениям, воспитанным под влиянием советской идеологии, обнаруживаются противоречия, обусловленные трактовками стереотипа. Социальная идентичность молодёжи включает противоречивые оценки советского образа жизни с учетом современных позиций в отношении к Западу. В исследовании были выявлены различия между функциями «либеральной» и «исторической» трактовки стереотипа железного занавеса.
Эволюция научных подходов к определению понятия правового регулирования в отечественном правоведении
Authors: Богатырёв Магомед Резванович
Published: October 2024

В юридической науке и практике термин «правовое регулирование», несмотря на широкое распространение и общеметодологическое значение для отраслевых наук, не имеет однозначного толкования. Плюрализм подходов к определению понятия правового регулирования не позволяет сформировать единую концепцию, определяющую природу и сущность данной базовой юридической категории. В условиях модернизации общественных отношений возникает необходимость ревизии, исследования и актуализации имеющихся в юридической науке подходов к данной категории, что и составляет цель настоящего исследования. В результате автор приходит к выводу о том, что в своем развитии категория «правовое регулирование» прошла несколько основных этапов, включая дореволюционный, советский и постсоветский (современный). Установлено, что советский период обусловил распространенный в настоящее время нормативно-этатистский подход, основанный на приоритете государства как источника формирования и обеспечительной силы действия юридических средств (норм права, правоотношений и правореализационных актов), лежащих в основе регулятивного воздействия права на общественных отношения и поведение субъектов.
Конституционно-правовые аспекты трансформации современного государства: особенности развития концепции суверенитета
Authors: Задорожная Евгения Владимировна
Published: October 2024

Развитие государства на современном этапе тесно связано с необходимостью правового обеспечения трансформации государства с учетом национальных интересов страны, защиты Российской Федерации от внешних и внутренних угроз, обеспечения ее независимости и территориальной целостности. Несмотря на многочисленность публикаций по проблематике различного рода трансформаций и отдельных аспектов государственного суверенитета, практически отсутствуют исследования, посвященные системному подходу к рассмотрению их взаимного влияния, в частности разновекторности воздействия цифровой трансформации на возникающие правовые отношения, в том числе с точки зрения обеспечения суверенитета Российской Федерации. Целью исследования является выявление факторов, дискуссионных аспектов, детерминирующих трансформацию как государства в целом, так и концепции государственного суверенитета. В результате исследования была определена устойчивая тенденция к актуализации известных и обоснованию новых видов суверенитета. Теоретико-методологические разработки вносят вклад в развитие концепции суверенитета современного государства.
APPLICATION OF FISHBONE DIAGRAM IN USING ROOT CAUSE ANALYSIS (RCA) FOR DEVELOPING OF REVENUE AND EXPENDITURE SYSTEM IN MANUFACTURING COMPANY
Authors: Fatmaria Tantri Sinta , Eltivia Nurafni , Djajanto Ludfi
Published: October 2024

This study aims to identify the root problems in developing income and expenditure systems in the PT ABC. This research uses qualitative methods with the Root Cause Analysis approach. The issues that arise in the company will be analyzed using the Fishbone Diagram. The result of this study explains that some problems occur in the company. The procedures, business processes, income, and expenditure in the enterprise are still done manually, so it takes a long time to analyze the factors of Man (user), Material (material/supporting documents), Machine (tools used), and Method (procedures/systems running). Based on the result of this study, PT ABC should have a website that can be used to process the cycle of income and expenses in real time. In this case, website design will be carried out to make it easier for companies to archive, create supporting documents, and report income and expenses. This finding will help PT ABC strengthen its internal control and increase the effectiveness of the company's business process. The difference between this research and previous research is that it uses a fishbone diagram approach to dig into the roots of problems that occur in companies. In the last research, no one had used a rooting approach and focused only on system development, so the issues that occurred needed to be described in detail. The limitation of this research is its focus on the root cause analysis of the revenue and expenditure cycle in manufacturing companies
THE INFLUENCE OF COMPANY SIZE, KAP SIZE, AND AUDIT COMMITTEE, ON AUDIT FEE
Authors: Muhsin Muhsin , Suryantini Suryantini , Elida Sri Syabanita
Published: October 2024

This research examines the impact of Company Size (UP), Public Accounting Firm Size (UK), and the Existence of an Audit Committee (KA) on Audit Fees in banking companies listed on the Indonesia Stock Exchange (BEI) during the 2016-2019 period. By using the Structural Equation Modeling (SEM) method with the Partial Least Square (PLS) approach via WarpPLS 8.0 software, the main findings show that UP, UK, and KA have a significant effect on Audit Fees.
The analysis confirms that company size (UP) is an important factor for auditors in determining the amount of audit fees because it influences the complexity of the audit. In addition, both the size of the Public Accounting Firm (UK) and the existence of an Audit Committee (KA) also influence the size of the auditor's fee, indicating that the selection of a Public Accounting Firm (KAP) and the adoption of an audit committee affect the company's audit fees. The results of this research provide important insights into the financial management of banking companies, especially in managing audit costs and decision making related to internal and external audits. The implications of these findings can help financial managers consider the factors that influence Audit Fees, so that they can manage costs efficiently and make more informed decisions regarding the audit process
INFLUENCE OF REGIONAL ORIGINAL REVENUE AND BALANCING FUNDS ON THE FINANCIAL PERFORMANCE OF THE REGIONAL GOVERNMENT OF JOMBANG DISTRICT
Authors: Anggraini Ullif Athiyah , Widajantie Tituk Diah
Published: October 2024

Regional government financial performance measures regional independence in managing potential sources of regional original income (PAD) as the primary value for financing regional expenditure so that it does not depend on central government balancing funds. This research aims to test and determine the influence of (PAD) and balancing funds on the financial performance of the Jombang Regency regional government. Quantitative methods are used in this type of research. The sample for this research is five years from the Jombang Regency regional government budget realization report for 2018-2022. The non-probability sampling method was used in this research, and saturated sampling techniques were utilized. The classical assumption test, multiple linear regression analysis, and hypothesis testing were used as data analysis using SPSS 26 tools. The results of this research were that PAD and balancing funds had a positive and significant effect on the financial performance of the Jombang Regency regional government
THE EFFECT OF CHANGES IN VALUE-ADDED TAX RATES (VAT) AND COST OF GOODS SOLD (COGS) ON SALES TURNOVER AT PT. VCS
Authors: Asah Maranatha Kezya Beauty Caesaria , Widajantie Tituk Diah
Published: October 2024

The increase in Value Added Tax (VAT) rates and the rise in Cost of Goods Sold (COGS) significantly impact the business strategy and profitability of the company. The research aims to examine the impact of the increase in VAT rate and changes in the Cost of Goods Sold on PT's business strategy and profitability. VCS. The method used is quantitative research using PT's sales data. VCS from 2018 to 2022, as the population was selected through a purposive sampling method. Data analysis was conducted using SPSS version 27. The research findings indicate that the increase in the value-added tax rate significantly impacts PT's sales revenue. VCS, while the increase in Cost of Goods Sold does not considerably affect the company's Sales Revenue
THE ANALYSIS OF THE EFFECT OF PROFITABILITY, LIQUIDITY, AND COMPANY SIZE ON TIMELINESS OF FINANCIAL REPORTING
Authors: Rizky Sari Fateh , Ratnawati Dyah
Published: October 2024

This study aims to determine the effect of profitability, liquidity, and company size on the timeliness of financial reporting of energy sector companies listed on the Indonesia Stock Exchange (IDX) in 2019-2022. The type of research used in this research is a quantitative approach. This research uses secondary data from the annual financial reports of energy sector companies listed on IDX for 2019-2020. The population in this study included all energy sector companies listed on the IDX in the 2019-2022 period. The sampling technique used in this research was purposive sampling, so the sample used was 18 companies. The data analysis used to test the hypothesis is logistic regression with a significance level of 5% and using SPSS version 29. The results of this study indicate that profitability and company size do not affect the timeliness of corporate financial reporting, as evidenced by the significance value > 0.05 in the hypothesis test results. Liquidity is proven to affect the timeliness of corporate financial reporting, with a significance value in the hypothesis test <0.05
ANALYSIS OF THE MARKETING MIX STRATEGY (7P) TO INCREASE SALES OF PROCESSED CASSAVA PRODUCTS AT UD "PURNAMA JATI" MEMBER
Authors: Abroor Muhammad Rifqi , Widayanti Sri , Roidah Ida Syamsu
Published: October 2024

One of the leading producers and exporters of cassava in the world is Indonesia. Jember Regency is one of the highest cassava production centers in East Java, with an annual production capacity of 9,492 tons. This processed tape food product, typical of Jember Regency, is produced from the high supply of cassava. There is a need to find processed cassava products considering the high interest in tape products because of their unique quality, so this product is much more popular as souvenirs or souvenirs typical of Jember. The research aims to perfect marketing tactics and determine how the marketing mix (7P) influences consumer decisions in purchasing processed cassava products from UD Purnama Jati Jember. Questionnaire methodology is a technique for collecting information through statements or questions asked to respondents. Because the p-value is smaller than 0.05, product, price, place, and employees influence the results of consumer purchasing decisions at UD Purnama Jati. However, because the p-value is more significant than 0.05, we can rule out the possibility that factors related to the product process, physical evidence, or advertising influence consumers' final purchasing decisions
ANALYSIS OF THE APPLICATION OF WORK DISCIPLINE AND WORK MOTIVATION IN IMPROVING THE PERFORMANCE OF NON ASN EMPLOYEES IN THE CLEANING SECTION AT THE CENTER FOR STATE CIVIL STAFF DEVELOPMENT IN BOGOR
Authors: Sunarto Ading , Latif Latif
Published: October 2024

This research is entitled "Analysis of the Application of Work Discipline and Work Motivation in Improving the Performance of Non-ASN Employees in the Cleaning Department at the Center for Civil Service Personnel Development in Bogor. This research aims to analyze the application of work discipline and work motivation in improving employee performance. The research method used is qualitative research with a non-probability sampling technique, namely purposive sampling. The data collection procedures for this research are observation, interviews, documentation, triangulation. The data analysis techniques in this research are data reduction, data presentation, drawing conclusions and verification, Strengths, Weaknesses, Opportunities, Threats (SWOT) analysis and Quantitative Strategic Planning Matrix (QSPM) analysis. The results of this research show that the implementation of employee work discipline is quite good, because there are some employees who obey the regulations set by the agency. Apart from that, the implementation of employee work motivation is good because there are awards given by agency leaders. By implementing work discipline and work motivation, employee performance can be improved. And employee performance is good because the resulting performance has a good impact on the individual and the agency. The results of the SWOT analysis show that it is in quadrant I, namely aggressive, where the values ​​of the available to take advantage of opportunities. And also the results of the QSPM analysis are that there are 5 priority alternative strategies that can be used as strategies to improve employee performance, including improving good service, employee attitudes and employee responsibility at 6.50, controlling work so that it runs professionally at 6.42, maintaining relationships. Good cooperation between employees and other agencies amounted to 6.13, increased potential employee abilities by 5.91, increased assertiveness and concern by 5.22