bluuebunny/crossref_metadata_2025 huggingface dataset:
Impacts of Biotechnologically Developed Microorganisms on Ecosystems
Authors: Celebi Dilek , Yilmaz Mustafa Tugrul , Dundar Munis
Published: October 2023

Climate change has imposed a significant struggle for survival most of the Earth’s species, highlighting the urgent need for a healthy and secure environment. Recent scientific investigations have primarily concentrated on the development and use of microorganisms as powerful biotechnological tools to address the escalating pollution that poses a severe threat to life. But this microorganisims long-term effects on biodiversity and ecosystems remain a subject of inquiry. In this comprehensive review, we aim to thoroughly evaluate the effects of microorganisms on the general ecosystem and critically assess the use of existing biotechnological tools developed to combat climate-related challenges. By shedding light on the potential implications, this review strives to contribute to a deeper understanding of the intricate interplay between microorganisms, ecosystems, and climate change mitigation.
Correlation of leucocyte and platelet indices in patients with type 2 diabetes mellitus with microvascular complications at a tertiary care hospital in south India – A prospective cross-sectional study
Authors: Gokul Raj , Yoganathan Chidambaram , Clement Jenil Dhas Christopher Paul , Abilash Nekkanti , Velammal Petchiappan , Bhargavi Kumar , Sujith Kumar Sivaraj
Published: October 2023

Objective. The present study was directed to assess the correlation between leukocyte and platelet indices and microvascular complications in patients with type 2 diabetes mellitus (T2DM).

Methods. A prospective cross-sectional study was conducted between January 2020 and May 2021 at a tertiary healthcare center. Sixty T2DM patients, who fulfilled the inclusion and exclusion criteria, were included into the study and divided into 2 groups: T2DM patients with microvascular complications and T2DM patients without vascular complications. Clinical history was taken and examinations (routine complete blood count) were done to obtain platelet indices, neutrophillymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR) were obtained and tabulated. A correlation was statistically analyzed from the obtained data, p value <0.05 was considered to be statistically significant.

Results. From the patients with microvascular complications, 18 cases suffered from retinopathy and nephropathy. Majority of the participants suffered from moderate non-proliferative retinopathy. The creatine median and absolute neutrophil count (ANC) were significantly higher in T2DM patients with microvascular complications (p<0.0001 and p<0.0054, respectively) compared to T2DM patients without vascular complications. No significant correlation was found between platelet indices, NLR, PLR with regard to fasting blood sugar, post prandial blood sugar, HbA1C in T2DM patients.

Conclusions. Since no significant correlation was found between the different platelet indices and microvascular complications, it is evident that these markers cannot be used as the predictors of microvascular complications in T2DM patients.
Hypoxia controls the expression of genes responsible for serine synthesis in U87MG cells on ERN1-dependent manner
Authors: Sliusar Myroslava Y. , Minchenko Dmytro O. , Khita Olena O. , Tsymbal Dariia O. , Viletska Yuliia M. , Luzina Olha Y. , Danilovskyi Serhij V. , Ratushna Oksana O. , Minchenko Oleksandr H.
Published: October 2023

Objective. Serine synthesis as well as endoplasmic reticulum stress and hypoxia are important factors of malignant tumor growth including glioblastoma. Previous studies have shown that the knockdown of ERN1 (endoplasmic reticulum to nucleus signaling) significantly suppressed the glioblastoma cell proliferation and modified the hypoxia regulation. The present study is aimed to investigate the impact of hypoxia on the expression of PHGDH (phosphoglycerate dehydrogenase), PSAT1 (phosphoserine aminotransferase 1), PSPH (phosphoserine phosphatase), ATF4 (activating transcription factor 4), and SHMT1 (serine hydroxymethyltransferase 1) in U87MG glioblastoma cells in relation to knockdown of ERN1 with the intent to reveal the role of ERN1 signaling pathway on the endoplasmic reticulum stress-dependent regulation of expression of these genes.

Methods. The control U87MG glioblastoma cells (transfected by empty vector) and ERN1 knockdown cells (transfected by dominant-negative ERN1) were exposed to hypoxia introduced by dimethyloxalylglycine for 4 h. RNA was extracted from cells and reverse transcribed. The expression level of PHGDH, PSAT1, PDPH, SHMT1, and ATF4 genes was studied by real-time qPCR and normalized to ACTB.

Results. It was found that hypoxia up-regulated the expression level of PHGDH, PSAT1, and ATF4 genes in control U87MG cells, but PSPH and SHMT1 genes expression was down-regulated. The expression of PHGDH, PSAT1, and ATF4 genes in glioblastoma cells with knockdown of ERN1 signaling protein was more sensitive to hypoxia, especially PSAT1 gene. At the same time, the expression of PSPH gene in ERN1 knockdown cells was resistant to hypoxia. The expression of SHMT1 gene, encoding the enzyme responsible for conversion of serine to glycine, showed similar negative sensitivity to hypoxia in both control and ERN1 knockdown glioblastoma cells.

Conclusion. The results of the present study demonstrate that the expression of genes responsible for serine synthesis is sensitive to hypoxia in gene-specific manner and that ERN1 knockdown significantly modifies the impact of hypoxia on the expression of PHGDH, PSAT1, PSPH, and ATF4 genes in glioblastoma cells and reflects the ERN1-mediated reprograming of hypoxic regulation at gene expression level.
Influence of drying and granulation process conditions on the characteristics of micronutrient chelates granules
Authors: Michałek Bernard , Bizon Katarzyna , Gierczyk Błażej , Wilk Tomasz , Rapp Magdalena
Published: October 2023

Fluidized-bed spray granulation (FBSG) enables manufacturing particles with desired characteristics, including particle size distribution (PSD), density, or dust content. This study investigated the effect of selected factors on the granules obtained in a continuous FBSG of chelated fertilizers for foliar applications. The effect of surfactant addition to the solution sprayed into the bed and perturbations of operating parameters on PSD and granules morphology was studied. The experiments were supplemented with calculations based on a population balance equation (PBE). It was shown that granules manufactured with the tenside addition are more regular in shape, and thus less prone to mechanical wear. It was demonstrated that increasing rotational mill speed does contribute to a slight increase in the amount of dust, but in the long term, it does not disturb the regular agglomeration process. The computational results confirm that, despite the complexity of the process, its description with PBE is feasible.
Phytochemical composition and antioxidant activity of leaves extracts of Coleus forskohlii L. collected from Al-Leith Area, Saudi Arabia
Authors: Sameeh Manal Y.
Published: October 2023

Background: wild Coleus forskohlii L. is a well-known traditional medicine for the treatment of many diseases because of its high forskolin content and several diterpenes. Objective: this study aimed phytochemical screening, finding of total phenolic content (TPC), total flavonoid content (TFC) and antioxidation activity of Coleus forskohlii L. leavse extracts in Al-Leith area, Saudi Arabia. Materials and Methods: dry leaves of wild C. forskohlii L. were used. Four solvents from diverse polarity groups were tested on these leaves, which are ethanol, ethyl acetate, chloroform, and hexane. Moreover, obtained extracts were used in phytochemical analyzing, finding of total phenols, and antioxidation activity. Results: showed the presence of phenols, flavonoids, tannins, alkaloids, Proteins, carbohydrates, saponins, and glycosides in Coleus forskohlii L. leaves. The highest value of total phenolic content (TPC) was significantly (P < 0.001) in ethanol extract (280.5±2.33 mg GAE/gm. Also, the highest value of total flavonoid content (TFC) was in ethanol extract (141.4±1.30 mg QE /g). The antioxidation activity was significantly (P < 0.001) higher in ethanol extract (78.55±2.23%), followed by ethyl acetate extract (60.18±1.21%), chloroform extract (36.11±2.54%), and lowest value in hexane extract (20.71±0.59%). The study clearly indicated that the leaves extract of C. forskohlli L. collected from Al-Leith region- Saudi Arabia has properties to be useful in pharmacological and biological industries.
Evaluating the Total Phenolic, Protein Contents, Antioxidant and Pharmacological Effects of Cynodon dactylon Extracts Against Escherichia coli and Staphylococcus aureus
Authors: Ibrahim Muhammad , Riaz Moazama , Ali Akbar , Shaheen Musarat , Rahman Shafiq ur , Aziz Riffat , Alamri Abdulhakeem S. , Alhomrani Majid , Dablool Anas S , Alghamdi Saad , Sameeh Manal Y. , Tashkandi Manal A
Published: October 2023

The study was aimed to characterize the antioxidant and anti-microbial activities of Cynodon dactylon with special reference on its precise biochemical analysis. Physiological analysis that total carotenoids content (0.3884 ± 0.0172 mg/g), total chlorophyll content (6.1460 ± 0.2915 mg/g), total phenolic contents (13.4703 ± 0.1494 mg/g), chlorophyll a (3.7708 ± 0.1528 mg/g, catalase (CAT) contents (40.2844 ± 0.1515 units/mg), total anthocyanin contents (5.0166 ± 0.2966 g–1 FW) total soluble proteins (2.9916 ± 0.1734 mg/g) and total flavonoids content (TFC) (4.7863 ± 0.0442 μg/g) was found higher in the leaves of the Cynodon dactylon whereas, chlorophyll b (2.4881 ± 0.1326 mg/g) was found higher in the stem of Cynodon dactylon, while, peroxidase (POD) contents (81.8763 ± 4.6609 units/mg) and superoxidase dismutase (SOD) activity (80.4346 ± 5.9367 units/mg) was investigated higher in roots of Cynodon dactylon. The anti-microbial activity of Cynodon dactylon extracts was performed using a good diffusion technique against two microbial strains. Among all the plant extracts, the methanolic extracts showed a maximum inhibition zone (26.87 mm) against anti-bacterial strain Escherichia coli whereas n-hexane extract showed a maximum inhibition zone (17.88 mm) against anti-fungal strain Candida albicans. This study reported the antimicrobial activity of Cynodon dactylon against some common pathogens such as Staphylococcus aureus, Escherichia coli, and Candida albicans, which are highly associated with nosocomial infection. From the given results it is concluded that Cynodon dactylon could be exploited in pharmacology due to its antioxidant and anti-microbial properties.
Glass Microspheres Thermo-Deformation Sintering Processes in the Technologies of Obtaining Materials for Underwater Technical Equipment
Authors: Kazymyrenko Yuliia , Solomoniuk Natalya , Drozd Oxana
Published: October 2023

In this work, the important scientific and technical problem of creating multifunctional composite materials for shipbuilding and ocean engineering was solved. The work aimed to study the thermal deformation processes of sintering glass microspheres to obtain lightweight glass composites with a cellular structure that provides positive buoyancy and sound insulation properties. For this purpose, glass microspheres of Na2O‒SiO2 and Na2O‒B2O3‒SiO2 composition with a dispersion of 10 to 60 μm were used as raw materials. They were sintered to form a closed, porous structure. The theoretical substantiation of technological parameters is based on the concepts of solid state and glassy state chemistry and physicochemical concepts of glass softening processes. The process of hot-pressing glass microspheres without plasticisers and additives was investigated. The author’s own laboratory equipment was used for the experiments. The sintering intensity was determined from the results of shrinkage processes; the kinetic shrinkage curves were constructed in semilogarithmic coordinates. The glass composite samples were examined by optical and electron microscopy. As a criterion, the storage of spherical microspheres under the influence of simultaneous heating to 700 °C with the application of pressure in the range of 0,5 to 1,5 MPa was chosen. It was established that the formation of a predominantly closed-porous structure of glass composites with a density of 350...600 kg/m3 occurs by the mechanisms of viscous glass phase flow through liquefaction processes in the walls of microspheres. At the same time, shrinkage processes in the linear direction reach up to 50%.

The acoustic properties were investigated by measuring the differences in sound pressure levels in octave frequency bands using a Kundt pipe. The water absorption of the glass composite samples was determined at hydrostatic pressures up to 20 MPa. The research results were compared with the characteristics of analogue composites, such as syntactic foams and foam glass. The developed materials can be used in the design and manufacture of technical equipment for research and maintenance of underwater infrastructure. The prospects for further research are related to the feasibility study and marketing research on implementing the developed glass composites.
Índice de calidad como indicador de efectividad en la potabilización del agua del río Carrizal
Authors:   Facultad de Posgrado Universidad Técnica de Manabí, Portoviejo, Manabí, Ecuador, Alcívar-Cedeño Ana Karina
Published: October 2023

La calidad del agua superficial utilizada para la potabilización es de suma importancia debido a que de ella depende la funcionabilidad que puedan tener los procesos dentro de una planta de tratamiento. Una forma de monitorear los ríos han sido los índices de calidad de agua. La Parroquia Rural San Antonio del Cantón Chone, Provincia de Manabí, Ecuador, recibe el agua tratada por una planta modular que tiene su captación en el río Carrizal, es por ello que el presente artículo contempla el análisis del índice de calidad de agua en el sitio de captación como indicador de efectividad en el proceso de potabilización. En el río, se establecieron tres puntos de muestreo y se evaluaron 9 parámetros de calidad en dos meses de temporada seca y dos meses de temporada lluviosa, a través de métodos gráficos y de ecuaciones, así mismo, la planta también fue monitoreada y comparada según la normativa vigente de calidad para agua potable. Los resultados del ICA-NSF en época de estiaje fueron 72.52 y 72.02, lo que refleja una calidad “BUENA” y en época invernal 74.79 y 74.78, una calidad igualmente “BUENA”, sin embargo, la turbidez se incrementa de verano a invierno en un 98,93%. Así mismo, la planta potabilizadora tuvo una buena calidad en la mayoría de los parámetros. Estos datos permitieron establecer que la planta de tratamiento proporciona efectividad en el proceso de potabilización con el agua que recibe de la captación en todos los parámetros a excepción del cloro libre residual.
Edaphic Beetles (Insecta: Coleoptera) in Three Different Land Use Systems in the Eastern Amazon
Authors: De Souza Helender Ueno Seelig , Guimarães Zilza Thayane Matos , De Almeida Nara Maria Silva , Neves Junior Afrânio Ferreira , De Souza Herberto Ueno Seelig , De Carvalho Adenomar Neves
Published: October 2023

Objective: The objective of this study was to evaluate edaphic beetles’ abundance, diversity indexes and composition dependence in different land-use systems (LUS) under tropical climate conditions.
 
Method: We surveyed three different LUS such as primary forest fragment (FFP), agroforestry system (SAF) and conventional agricultural cultivation (CAC) in Eastern Amazon. The edaphic beetles were collected using pitfall traps, identified to the family taxonomic level and classified into trophic guilds (carnivore, detritivore, fungivore, and/or herbivore).
 
Results and conclusion: All LUS showed strong dominance by Scarabaeidae and Staphylinidae families. The edaphic beetles community is influenced by the LUS, since the highest rates of abundance, average richness, diversity and evenness were found in the CAC. Edaphic beetles’ composition is dependent to natural vegetation, which accumulated richness is the greatest parameter related to natural vegetation.
 
Research implications: No-tillage cultivation, with homogeneous vegetation formed by decayed plant material from the last culture cycle, can improve and preserve beetles’ detritivore trophic guild. Due to the edaphic beetles’ composition dependence to natural vegetation, is important to preserve forest fragments near altered landscapes to ensure better conditions for this organism’s reestablishment.
 
Originality/value: Edaphic beetles have rarely been studied under different LUS with tropical conditions, particularly in the Eastern Amazon. Comprising these organisms distribution pattern after land-use changes is essential for ecological conservation implications.
Modelling and optimization of copper removal from water using carbon nanotubes with RSM and ANN
Authors: ÇALGAN Elif , OZMETİN Elif
Published: October 2023

In this study, it was aimed to remove heavy metal copper from aqueous solutions by using MWCNT-OH, which is a multi-walled carbon nanotube. Modelling and optimization were performed using the Response Surface Method (RSM) and Artificial Neural Networks (ANN). Model equations were derived by both methods. ANOVA analyses were performed with RSM to determine the significance of the parameters on removal efficiency and adsorption capacity. Contour graphs showing the binary parameter interactions were obtained. Optimization was carried out to obtain the maximum removal efficiency and maximum adsorption capacity using both RSM and ANN. Using RSM and ANN, the maximum copper removal efficiencies were obtained at 45.1% and 39.1%, while the maximum adsorption capacities were found to be 16.7 mg/g and 17.12 mg/g, respectively. In addition, test experiments and modelling methods were compared, revealing that the modelling capability of ANN was superior to that of RSM.
Mikronükleus (MN) ve Comet Assay testlerinin farklı hayvan türlerindeki uygulamalarına örnekler
Authors: KURUCU Gülşah , BOSTANCI Derya
Published: October 2023

Farklı hayvanların dokularında biriken pek çok kirletici faktör canlıda genotoksik etki göstermektedir. Bu etkinin değerlendirilmesinde kullanılan genotoksisite testleri; kirlilik ajanlarının hayvanlarda DNA hasarına neden olup olmadığının belirlenmesine olanak sağlar. Bu faktörlerin etkilerini belirleyebilmek için farklı hayvan dokularında pek çok test sistemi geliştirilmiş ve genotoksisite testleri büyük önem kazanmıştır. Bu çalışmada, genotoksik hasarın belirlenmesinde çok yaygın olarak kullanılan iki test yöntemi olan Mikronükleus ve Comet Assay testleri karşılaştırılmış, avantaj ve dezavantajları belirlenerek farklı hayvan türlerinde yapılan çalışmaların değerlendirilmesi amaçlanmıştır.
Obtención de polifenoles de cáscara de piña usando hidrosecado conductivo-microondas y solventes de punto eutéctico profundo
Authors: Vargas Serna Claudia Liliana , Latorre-Castaño Daniela , Nadezda Moreira-Muñoz , Claudia I Ochoa-Martínez , Vélez-Pasos Carlos
Published: October 2023

La piña es una fruta tropical con alta demanda para su industrialización. Sin embargo, sólo entre en 30 y el 50% del peso total del fruto es aprovechable lo que genera un alto volumen de residuos contaminantes. El objetivo de esta investigación fue extraer compuestos fenólicos de residuos agroindustriales de piña mediante tecnologías amigables.  Se evaluó el efecto del secado empleando la tecnología de hidrosecado conductivo (muestra fresca y seca) y el efecto del tipo de solvente de punto eutéctico profundo (cloruro de colina - ácido málico y cloruro de colina – glicerol) sobre la extracción asistida por microondas de compuestos fenólicos de cáscara de piña. Se determinó el contenido total de compuestos fenólicos, el rendimiento del proceso, la capacidad antioxidante y el porcentaje de inhibición del radical DPPH. El secado tuvo efecto significativo sobre las variables de respuesta y, en general, el tipo de solvente no tuvo efecto. La mayor concentración de compuestos fenólicos fue 26.29 ± 5.22 mg GAE/g ms, con un rendimiento de 2.6288 ± 0.5220 % (g GAE/g ms) y una capacidad antioxidante de 2.4816 ± 0.0779 mM TE/g. Los extractos obtenidos a partir de muestra seca presentaron la mayor capacidad antioxidante (88.08 ± 1.44% de inhibición del radical DPPH). Estos resultados indican que el uso de tecnologías verdes de extracción es una alternativa viable para la valorización de residuos de piña, comparado con la extracción con etanol.
Synthesis, Design and Evaluation of Innovative Combined Nano-Catalysts Supported on Activated Carbon Prepared from Apricot Shells
Authors: Hameed Shymaa A. , Ben Amar Raja , Hamad Khaleel I. , Jarullah Aysar T.
Published: October 2023

Abstract: Clean fuel oil is crucial for a healthy environment and modern life. Therefore, removing sulfur-containing compounds is an effective issue using various techniques for desulfurization. In this study, the oxidation desulfurization (ODS) process was utilized with respect to the prepared new activated carbon (AC) made from apricot shells (AS) loaded by two combined active metals (Nickel-Cobalt-Manganese (NCM) and Nickel-Cobalt-Manganese-Molybdenum (NCMM)). Several characteristics related to the catalysts prepared (mainly SBET, pore volume, FTIR, TGA, SEM, EDX and XRD) have been investigated to analyze the produced nanocatalysts. The new nanocatalysts (NCM/AC and NCMM/AC) were generated by using the impregnation wetness incipient (IWI) method and evaluated for their ability to remove sulfur compounds from whole-cut fuel (from 29-345 °C) based on the air as an oxidant within batch reactor under the following conditions: air flow rate = 2 lit/min, reaction temperature = 90 °C, and reaction time of 60 min for both catalysts. It was found that Nano catalyst NCMM/AC performed better overall in removing sulfur components (57.29 %) than Nano catalyst NCM/AC (44.75 %), and excellent properties have been observed.
PREREQUISITES FOR THE CREATION OF MECHANISED LIFTS FOR MAINTENANCE OF OVERHEAD POWER LINES
Authors:   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Bieliaieva Anastasia
Published: October 2023

The article is an overview and the information presented is of an overview nature and is devoted to a very important topic in our time, namely the prerequisites for the creation of mechanized lifts for the maintenance of overhead power lines. The purpose of the work is to create prerequisites for the synthesis of new designs of individual mechanized lifts using the method of differential morphological analysis. The design of the lifts should ensure operation on low-voltage overhead power lines with supports of different cross-sections. The main design and operational requirements for lifts were defined, namely: the lifter must be universal for the power line supports used or be quickly reconfigured in the field and without the use of special tools; the hoist must have a reliable fixation in the working position on the power line support,LEP, which prevents involuntary sliding or falling of the lift, and also does not depend on the state of the power unit, power supply, etc.; the lift must use only the existing structural elements of the power line support for its movement;it is not allowed to equip the supports with addi-tional elements such as hanging cables, guides, etc.; the lift should not damage the structural elements of the supports used for its movement, that is, there should be no damage to the paint, anti-corrosion coating on metal supports, formation of dents and other damage on concrete and wooden supports, this is especially important in climatic conditions, in which Ukraine is located, since such damages become foci of corrosion and destruction of the support structure;the lift must have mass and dimensional characteristics that allow it to be transported in cargo or cargo-passenger vehicles of category "B" and above, as well as on trailers (semi-trailers) to them. We considered the classification of the supports of power lines themselves, the classification of lifts for maintenance of power lines. The classification of elevators in Ukraine was also considered, the shortcomings of existing elevators were determined, and based on the analysis of existing elevators, the closest analogue of the structure of the elevator planned to be developed was proposed.
Between Pan and the Gray Wolf: Dionysian Variations
Authors:   Novosibirsk State Theater Institute, Kuznetsov Ilya V.
Published: October 2023

Mariam Petrosyan’s novel “The House in which ...” uses a model of two worlds and involves several teenage trickster heroes who can go into another reality called “The Forest”, as well as take other children there. The paradigm for such a plot structure in European literature aimed at children and adolescents is D. Barry’s book “Peter Pan”. Her hero is correlated with a pagan Pan, and he takes boys from ordinary families to his island. Peter Pan does not want to grow up and does not know love; the children he takes away must be cheerful and heartless. The immobile time on Peter Pan Island and the lack of love there contrast this world with Christian culture, but they bring it closer to the pagan – Dionysian world, in the words of F. Nietzsche. This construction proved to be very fruitful in the European mass literature of the 20th and 21st centuries. However, in Mariam Petrosyan’s novel, in contrast to this literature, the images of tricksters are not cultivated. They preserve and show the werewolf, dark, dangerous nature. This interpretation of the trickster is connected with the specifics of the Russian literary tradition. Since the time of Romanticism, which established the model of two worlds, the other world in this tradition was usually presented as hostile to man. In the modern era, the two-world model has regained its validity. This was largely due to the fact that the aesthetics of Russian modernism adopted the Nietzschean concept of Dionysianism, specifically interpreted as an appeal to soil culture. However, on the part of traditionally thinking writers, such pochvennichestvo met with rejection. He was criticized by Ivan Bunin, in the story “Sukhodol”, contrasting Christianity with him as the only mechanism for preserving cultural memory. In the 21st century, in the stories of Elena Chizhova, Irina Bogatyreva, Evgenia Nekrasova, the model of two worlds with an appeal to soil culture was again actualized. The characters of the other world were depicted in them as assistants to the heroes, but at the same time unsafe and alien creatures. This interpretation of the trickster is close to the image of a magical assistant in a fairy tale. It was she who was realized in the novel by Mariam Petrosyan.
Cobertura do pré-natal odontológico nas regiões de saúde do Ceará
Authors: Barros Lara Maria Lima de Campos , Duarte Antônio Átila Marques , Marques Karyne Barreto Gonçalves , Marcelo Maria Elisa Machado Ferreira , Aquino Icaro Santiago de , Gadelha Cinthia Nara Teixeira , Marques Paulo Leonardo Ponte
Published: October 2023

Objetivo: Avaliar a cobertura do pré-natal odontológico nas Áreas Descentralizadas de Saúde do estado do Ceará na Atenção Primária à Saúde (APS), utilizando o indicador “proporção de gestantes com atendimento odontológico realizado” do Ministério da Saúde. Métodos: Estudo transversal, quantitativo, dados secundários sociodemográficos e odontológicos foram coletados no período do primeiro e segundo quadrimestre de 2022. Organizados em planilhas eletrônicas e analisados por meio de estatística descritiva. Resultados: Um total de 83 municípios do Ceará (45,1%) obtiveram resultado ótimo no indicador. Nos dois quadrimestres, a Região de Saúde Litoral Leste teve a maior média de proporção de gestantes com atendimento odontológico realizado. No primeiro quadrimestre a maior média com 69% ficou as populações de médio e intermediário porte, já no segundo quadrimestre a população que obteve a maior média com 84% foi a de pequeno porte. Conclusão: O Ceará teve uma ótima cobertura dos atendimentos odontológicos às gestantes, demonstrando que o estado está organizado e comprometido na APS, reafirmando o protagonismo no desenvolvimento de políticas públicas.
Results of the Pediatric Shaft Femur Fracture Treated with Closed Rigid Lateral Trochanteric Entry Intramedullary Nail in North Indian Population
Authors: Kansay Rajeev , Vashisht Saurabh , Kothari Siddharth , Soni Ashwani , Jindal Rohit , Garg Sudhir
Published: October 2023

Objectives

The femoral shaft fractures constitute 1.6% of the pediatric fractures. Intramedullary nailing is a common mode of fixation in older children and adolescents. The rigid intramedullary locking nail is a preferred choice over flexible nails in overweight patients and children older than 11 years of age. The adolescent age group with skeletal immaturity deserves special attention from the surgeons because of grave complications like avascular necrosis of the femur head and angular deformities. The aim of this study is to report the outcome of an adolescent femur shaft fracture treated with a rigid intramedullary interlocking nail in North Indian patients.

Material and Methods

This is a retrospective analysis performed by retrieving records of 19 patients. Patients with open fractures, polytrauma and neurovascular injuries were excluded. The preoperative and post-operative radiographic orthogonal views were analyzed to assess parameters like alignment, union and avascular necrosis (AVN).

Results

The mean age was 12.3 years. The mean follow-up was 1.5 years. The average time for union was 8 weeks. All the fractures were united in an acceptable alignment and rotation. There was no avascular necrosis, angular deformity and infection. The mean femur length discrepancy was 7 mm.

Conclusion

The rigid intramedullary interlocking nail is a valuable option for the fixation of femoral shaft fractures in an adolescent age group with a good union rate and minimal complications.
Rules for Forming of Bibliographic Record Heading in the New National Standard
Authors: Kalinina Galina P.
Published: October 2023

The article presents the detailed comments of the standard developer and the text of the SIBID national standard – GOST R 7.0.80–2023 “Bibliographic record. Heading. General requirements and rules” which puts into action from August 1, 2023. This standard brings about a change in the structure and composition of bibliographic record heading thus enabling to actualize and unify the method of its compiliation for all kinds of information resources. The GOST is intended for use by centers of the national (state) bibliography, libraries, publishers, information services and other organizations and structures dealing with the bibliographic activities. In this GOST in comparison with its predecessor of 2000 a number of new clauses is introduced, as well as the volume of information is broadened about identifying features, punctuation requirements and fully renewed album of specific examples. The rules for presentation of names of secular leaders and ecclesiastics of different confessions are fully shown because they often cause difficulties for a bibliographer. The given document should improve the searching efficiency and velocity of bibliographic information exchange.
Kurgan Regional College of Culture in Bibliographic Manuals
Authors: Potanina Elena A.
Published: October 2023

The article considers the activities of a team of teachers and students of the Library Department of the Kurgan Regional College of Culture in creating of retrospective bibliographic indexes reflecting publications of different kinds (including for nowadays electronic ones) about this educational institution. The author shows the developing of different approaches to the selection and presentation of bibliographic data for two decades. During this period 3 issues of this manual have been published: “Kurgan Regional Specialized School (1956—1996). Documents and Facts” (2000), “Kurgan Regional Specialized School of Culture (1996—2001). Documents and Facts” (2001), “Kurgan Regional College of Culture (2002—2020). Documents and Facts” (2021). The importance of local history, factual and biographic information contained in these book editions is specially underlined.
The Collections and Catalog of Officer’s Library of the Staff of Trans-Amur Military District of the Separate Corps of Frontier Guards before the First World War
Authors: Panchenko Anatoly M.
Published: October 2023

The high priority of studying the library collections and reading circle of frontier guards is stipulated by the important role that libraries play in organization leisure time for this category of military servicemen, whose service often takes place in so called “bear corners”, outside of civilization. In connection with the absence of publications on the history of Officer’s Library of the Staff of Trans-Amur Military District of the Separate Corps of Frontier Guards the presented article for the first time gives careful consideration its collection, acquisition of books and periodicals for different departments and underdepartments by January 1, 1911. The results obtained show that the catalog in a bibliographic sense has been prepared professionally. The book collection of the library contributed to the professional development of guards and solution of their official tasks, as well as to the organization of cultural leisure activities. The owner of the catalog served as the base for an analysis of this collection is clearly defined. The editions prepared by the Staff of the District and later presented in the book catalog are specially identified. The fulfilled investigation broadens and advances the understanding of this library, its collection specific features and also of publishing activities of the Staff of District and its participation in book holdings acquisition.
THE READING EXPERIENCE OF CHILDREN AND ADOLESCENTS LEFT WITHOUT PARENTAL CARE
Authors: Proekt Yuliya L. , Tsybulskaya Darya A. , Olenina Anna A.
Published: October 2023

Reading fiction is considered as a tool to support the psychosocial development of children left without parental care. The paper describes the results of the study aimed to identify the semantic characteristics of the reading experience of children and adolescents left without parental care. The main characteristics of the reading experience and their connection with personal characteristics of the students are analysed. It is shown that children and adolescents left without parental care are characterised by greater emotional stability and personal maturity when they have more versatile and rich reading experience.
THE PROBLEM OF LINGUACULTURAL VARIABILITY IN TEACHING ENGLISH AS AN INTERNATIONAL LANGUAGE
Authors: Budnikova Alina A.
Published: October 2023

The article is devoted to the methodological problem of the English language linguistic and cultural variability within the university-level foreign language education. The author summarises the geopolitical and linguistic prerequisites for the pluricentrisation of the English language, provides arguments for the problem’s relevance for modern linguodidactics, and considers the theoretical foundations and practical solutions for studying varieties of the English language in higher education from the standpoint of the concept of Teaching English as an International Language.
THE CONCEPT OF SOCIAL FACT:
MAIN RESEARCH APPROACHES
Authors: Platonova Svetlana I.
Published: October 2023

Social fact is a complex multidimensional phenomenon that has recently attracted
the attention of social scientists. The essence of social fact cannot be explained within the
framework of only one theory. The article analyses the nature of social fact within the framework
of classical and non-classical social knowledge, as well as modern theories of structuration by
E. Giddens, communicative rationality by P. Bourdieu, the theory of speech acts by J. Searle,
and the concept of social ontology by B. Epstein. The problem of hypostasising concepts and the
phenomenon of relativistic social ontology are considered. It is concluded that it is necessary to
develop intersubjective forms of explanation of social facts and to overcome psychologisation
and individualisation of social theories.
IDEAS ABOUT MARITAL RELATIONS AMONG WOMEN WITH DIFFERENT EXPERIENCE OF FAMILY LIFE
Authors: Kuzmishina Tatyana L. , Blyanikhov Roman V.
Published: October 2023

The paper reveals the peculiarities of the ideas of women of different ages who have different experience of family life about the specifics of their relationships with their spouses. The results of the empirical study of marital relationships at different stages of life together are presented. The conclusions based on the results of the conducted research can form a basis for the development of a programme of psychological support for married couples experiencing crisis periods. The data presented in the article are of interest to practicing psychologists working with married couples.
THE DEVELOPMENT OF METHODOLOGICAL APPROACHES TO TEACHING THE INSTRUMENTS OF THE BAYAN-ACCORDION GROUP IN CHINA WITH THE USE OF INTERACTIVE DIGITAL TECHNOLOGIES
Authors: Jiujiu Wang
Published: October 2023

The article discusses the current state of bayan-accordion pedagogy in China. It is noted that in the conditions of integration of Russia and China, bayan-accordion pedagogy in China is at the stage of revival. To date, there are no unique methodological approaches to learning to play the button accordion and accordion in China: mainly, the entire pedagogical process is based on borrowed Russian and Western methods, as well as on the educational developments of China in the beginning and middle of the last century, presented through the prism of digitalisation. The above makes it impossible to organise an effective educational process, including in the existing conditions of generational change, as well as the peculiarities of music education. For the further revival of the Chinese bayan-accordion art, it is relevant to apply modern pedagogical practices based primarily on interactive digital technologies.
DISCIPLINARY LITERACY IN
THE GLOBAL SCHOLARLY COMMUNITY:
CHALLENGES AND SOLUTIONS
Authors: Kudryavtseva Natalia F. , Malakhovskaya Maria L. , Panteleeva Lyudmila V.
Published: October 2023

Russian university graduates and academics face significant challenges to become
full-fledged participants of the global scholarly community. One of the most common, yet
sometimes overlooked causes of this situation is the lack of disciplinary literacy. Disciplinary
literacy is defined as the ability to appropriately participate in the communicative practices of a
discipline. The paper investigates the factors that lead to the expansion of the requirements for
disciplinary literacy in today’s globalised world. Based on the analysis of literature and their
own experience of teaching ESAP (English for Specific Academic Purposes) in a pedagogical
university, the authors put forward the idea that in many cases the best way to tackle the
problems of disciplinary literacy may be to use elements of the constructivist approach to
teaching this subject.
THE “BODILY GEOGRAPHY OF EMOTIONS” METHOD: A NEW MODIFICATION FOR DIAGNOSTICS OF THE EMOTIONAL SPHERE IN PREGNANT WOMEN
Authors: Korgozh Maria A.
Published: October 2023

The article presents the author’s modification of the projective technique “Bodily Geography of Emotions”, which can be used to assess the characteristics of women’s emotional sphere, as well as to identify the presence and severity of various bodily manifestations of emotions and feelings. The procedure, data processing and interpretation of the technique’s results are described using the example of psychological assessment of a pregnant woman. The author considers additional possibilities of using the modification of the technique in psychological counseling for women in the prenatal and postpartum periods, as well as outside the childbirth situation in the presence of various features of reproductive health.
The maximal and current accuracy of rigorous protein-ligand binding free energy calculations
Authors: Ross Gregory A , Lu Chao , Scarabelli Guido , Albanese Steven K. , Houang Evelyne , Abel Robert , Harder Edward D. , Wang Lingle
Published: October 2023

It is now well recognized that computational techniques can greatly speed up the identification of hits and accelerate the optimization of such hits to lead series and development candidate molecules. In particular, a class of rigorous physics-based methods known as free energy perturbation (FEP) have emerged as the most consistently accurate relative affinity prediction tool available to support such efforts. Yet, there still remains uncertainty about how accurate these techniques are, and indeed, how accurate they can ever be. In this study, we assemble what we believe to be the largest publicly available data set of proteins and congeneric series of small molecules to date and assess the accuracy of the leading FEP workflow in predicting relative binding affinities. To ascertain the limit of achievable accuracy, we survey the reproducibility of experimental relative affinity measurements by comparing chemical series that have been assayed by two or more different techniques. We find a wide variability in experimental accuracy and a general correspondence between binding and functional assays. When the protein and ligand structures from our data set are prepared with care, we find that FEP can achieve a level of accuracy close to what we find in our experimental survey. Throughout, we highlight reliable protocols that can help maximize the accuracy of FEP in prospective studies.
Wavelength Tunable Infrared Perfect Absorption in Plasmonic Nanocrystal Monolayers
Authors: Chang Woo Je , Sakotic Zarko , Ware Alexander , Green Allison M. , Roman Benjamin J. , Kim Kihoon , Truskett Thomas M. , Wasserman Daniel , Milliron Delia J.
Published: October 2023

The ability to efficiently absorb light in ultrathin subwavelength) layers is essential for modern electro-optic devices, including detectors, sensors, and nonlinear modulators. Tailoring these ultrathin films’ spectral, spatial, and polarimetric properties is highly desirable for many, if not all, of the above applications. Doing so, however, often requires costly lithographic techniques or exotic materials, limiting scalability. Here we propose, demonstrate, and analyze a mid-infrared absorber architecture leveraging monolayer films of nano-plasmonic colloidal tin-doped indium oxide nanocrystals (ITO NCs). We fabricate a series of ITO NC monolayer films using the liquid-air interface method; by synthetically varying the Sn dopant concentration in the NCs, we achieve spectrally selective perfect absorption tunable between wavelengths of two and five micrometers. We achieve monolayer thickness-controlled coupling strength tuning by varying NC size, allowing access to different coupling regimes. Furthermore, we synthesize a bilayer film that enables broadband absorption covering the entire mid-wave IR region (λ = 3−5 μm). With perfect absorption in monolayer films only hundredths of a wavelength in thickness, we demonstrate a scalable platform enabling strong light-matter interaction, with potential applications for molecular detection and ultrafast nonlinear optical applications.
Polymer brush bilayer under non-equilibrium shear inversion: An MD simulation approach
Authors: Edwards Mike
Published: October 2023

The polymer brush bilayer under non-equilibrium shear inversion is studied by means of MD simulations with Langevin and DPD thermostats. The temporal evolution of the shear stress reveals that there is an overshoot during shear inversion only with hydrodynamic interactions and the electrostatic interactions completely suppress this overshoot. The overshoot in the shear stress takes place moments after the chains stretch strongly in the opposite shear direction and before the new stationary shear is established. Therefore, nature uses the electrostatic interactions between monomers i.e. Polyelectrolyte brushes to suppress mechanical instabilities in mammalian knee joints which is a very surprising outcome. The results of this study could shed light to our understanding from complex behavior of soft matter systems.
Application of Taylor Vortex Flow Reactor Enabling Precise Control of Nucleation in Reactive Crystallization
Authors: Hosoya Masahiro , Manaka Atsushi , Kawajiri Takahiro , Ohara Takafumi
Published: October 2023

A system that requires slurry handling such as reactive crystallization is not usually compatible with continuous flow synthesis due to the risk of clogging. Here we suggest the use of a Taylor vortex flow reactor to achieve the robust process for imination with reactive crystallization under continuous flow conditions. A Taylor vortex flow reactor realizes high shear stress and mixing efficiency, which accelerate the timing for nucleation of target imines and enable precise control of nucleation in reactive crystallization. A Taylor vortex flow reactor also mitigates the risk of adhesion to the flow reactor and clogging in reactive crystallization.
Markov state models: to optimize or not to optimize
Authors: Arbon Robert , Zhu Yanchen , Mey Antonia S. J. S.
Published: October 2023

Markov state models (MSM) are a popular statistical method for analyzing the conformational dynamics of proteins, including protein folding. With all statistical and machine learning (ML) models choices must be made about the modeling pipeline that cannot be directly learned from the data. These choices, or hyperparameters, are often evaluated by expert judgment or, in the case of MSMs, by maximizing variational scores such as the VAMP-2 score. Modern ML and statistical pipelines often use automatic hyperparameter selection techniques ranging from the simple: choosing the best score from a random selection of hyperparameters to the complex: optimization via e.g., Bayesian optimization. In this work, we ask whether it is possible to automatically select MSM models this way by estimating and analysing over \num{16000000} observations from over \num{280000} estimated MSMs. We find that differences in hyperparameters can change the physical interpretation of the optimization objective making automatic selection difficult. In addition, we find that enforcing conditions of equilibrium in the VAMP scores can result in inconsistent model selection. However, other parameters which specify the VAMP-2 score (lag time and number of relaxation processes scored) have only negligible influence on model selection. We suggest that model observables and variational scores should only be a guide to model selection and that a full investigation of the MSM properties be undertaken when selecting hyperparameters.
Diazene-Catalyzed Oxidative Alkyl Halide-Olefin Metathesis
Authors: Kellner-Rogers Julian , Wang Rina , Lambert Tristan
Published: October 2023

The first platform for oxidative alkyl halide-olefin metathesis is described. The procedure employs diazenes as catalysts, which effect cyclization of alkenyl alkyl halides to generate cyclic olefins. Mechanistically, the diazene catalyst is converted to a hydrazonium intermediate by alkylation with the alkyl halide component followed by tautomerization. The resulting hydrazonium ion reacts with the olefin component through [3+2] cycloaddition and cycloreversion reactions, leading to new olefin and hydrazonium moieties. Hydrolysis of the newly formed hydrazonium was found to outcompete retro-tautomerization / dealkylation, thus furnishing a carbonyl product instead of an alkyl halide. For this reason, the process is termed oxidative alkyl-halide olefin metathesis. Adventitious O2 and H2O were sufficient for catalyst turnover. The synthesis of phenanthrene, coumarin, and quinolone derivatives is demonstrated, as well as the potential to apply this strategy to other electrophiles.