bluuebunny/crossref_metadata_2025 huggingface dataset:
Nutrition regulates sex expression in a gender diphasy plant, Lilium concolor var. megalanthum
Authors: Chen Xin , Wang Lei , Yan Xingfu , Tang Zhanhui
Published: September 2023

Introduction

The evolution and maintenance of plant polymorphism have always received much attention. Gender diphasy is a rare sexual system. Plant individuals with gender diphasy can adjust the resource allocation of different functional organs according to the changes of environmental conditions to regulate the sex expression of individuals, and the sex expression can be converted between years. However, our understanding of sex expression in plants is still very insufficient. In this study, we explored whether the perennial plantLilium concolorvar.megalanthumhas a gender diphasy system and whether environmental resource availability affects its resource allocation and sex expression.

Method

By collecting the bulbs of two sexual phenotypes (male and hermaphrodite) in the field and simulating the application of different levels of nutrients under the same habitat conditions, the growth and reproduction indexes and sex expression of plants in two years (2021 and 2022) were measured to evaluate the resource allocation strategy and sex expression pattern ofLilium concolorvar.megalanthum.

Results

We found that the sex expression ofLilium concolorvar.megalanthumwas variable in continuous years. Under limited resources,Lilium concolorvar.megalanthumincreases the biomass resources of the leaves and has a longer flowering period. Resource availability regulates the growth, reproduction and sex expression ofLilium concolorvar.megalanthum. Bulb size is the main factor affecting its growth, reproduction and sex expression after accumulating sufficient resources.

Discussion

This study confirms thatLilium concolorvar.megalanthumhas gender diphasy system. There is a strong trade-off between growth and reproduction under limited resources. Nutrient levels can regulate the reproduction and sex expression process ofLilium concolorvar.megalanthum. With the growth ofLilium concolorvar.megalanthumin consecutive years, the size dependence of bulbs may be the decisive factor in its sex expression.
Effect of the pandemic on prehospital management of patients with mental and behavioral disorders: a retrospective cohort study
Authors: Kintrilis Nikolaos , Blek Natasza , Blek Sergiusz , Olkiewicz Aleksandra , Ladny Jerzy Robert , Szarpak Lukasz
Published: September 2023

The novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection and the accompanying coronavirus disease (Covid-19) have shifted the priority of human and technical resources toward their handling, thus affecting the usual standards of care for populations diagnosed with other clinical entities. The phenomenon becomes even more apparent in patients with presenting symptoms of mental and behavioral disorders, a category already vulnerable and underrepresented in regard to its prehospital approach and management. For the purposes of the current retrospective cohort study, we used records of the Polish National Emergency Medical Service Command Support System for the time period between April 1, 2019 and April 30, 2021, the official register of medical interventions delivered in Poland by Emergency Medical Services (EMS). We aimed to examine the potential impact of the COVID-19 pandemic across the Masovian Voivodeship on individuals seeking medical care for mental and behavioral disorders pertaining in the “F” category of the International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10). We examined the individuals’ baseline characteristics, prehospital vital parameters and EMS processing times in a population of 59,651 adult patients (04/2019–03/2020, 28,089 patients, 04/2020–03/2021, 31,562 patients) handled by EMS teams. Compared to pre-COVID-19, EMS personnel handled fewer patients, but more patients required mental and behavioral care. Throughout the duration of the pandemic, all prehospital time periods were significantly delayed due to the increased time needed to prepare crew, vehicles, and technical equipment to ensure COVID-19 prevention and overcrowding in Emergency Departments (EDs).
XGSleeve: detecting sleeve incidents in well completion by using XGBoost classifier
Authors: Somi Sahand , Jubair Sheikh , Cooper David , Wang Peng
Published: September 2023

The sliding sleeve holds a pivotal role in regulating fluid flow during hydraulic fracturing within shale oil extraction processes. However, concerns persist surrounding its reliability due to repeated attempts at opening the sleeve, resulting in process inefficiencies. While downhole cameras can verify sleeve states, their high cost poses a limitation. This study proposes an alternative approach, leveraging downhole data analysis for sleeve incident detection in lieu of cameras. This study introduces “XGSleeve,” a novel machine-learning methodology. XGSleeve amalgamates hidden Markov model-based clustering with the XGBoost model, offering robust identification of sleeve incidents. This method serves as an operator-centric tool, addressing the domains of oil and gas, well completion, sliding sleeves, time series classification, signal processing, XGBoost, and hidden Markov models. The XGSleeve model exhibits a commendable 86% precision in detecting sleeve incidents. This outcome significantly curtails the need for multiple sleeve open-close attempts, thereby enhancing operational efficiency and safety. The successful implementation of the XGSleeve model rectifies existing limitations in sleeve incident detection, consequently fostering optimization, safety, and resilience within the oil and gas sector. This innovation further underscores the potential for data-driven decision-making in the industry. The XGSleeve model represents a groundbreaking advancement in sleeve incident detection, demonstrating the potential for broader integration of AI and machine learning in oil and gas operations. As technology advances, such methodologies are poised to optimize processes, minimize environmental impact, and promote sustainable practices. Ultimately, the adoption of XGSleeve contributes to the enduring growth and responsible management of global oil and gas resources.
Nivolumab and daratumumab combination regimens for the treatment of relapsed and refractory multiple myeloma: results of a randomized phase I/II clinical trial
Authors: Abdallah Al-Ola , Lesokhin Alexander , Wrobel Tomasz , Jamroziak Krzysztof , Dytfeld Dominik , Touzeau Cyrille , Suvannasankha Attaya , Leleu Xavier , Silbermann Rebecca , Khan Abdullah M. , Kumar Shaji , Gertz Morie , Laubach Jacob P. , Jou Ying-Ming , Bar Merav , Das Prianka , Wang Yu , Demers Korey , Stong Nicholas , Perumal Deepak , La Motte-Mohs Ross , MacLachlan Kylee , Dimopoulos Meletios-Athanasios
Published: September 2023

Purpose

The phase I/II trial CheckMate 039 (NCT01592370) evaluated the safety, tolerability, and efficacy of nivolumab-daratumumab (ND) in patients with relapsed/refractory multiple myeloma (RRMM).

Methods

Patients with RRMM were randomized to receive ND with or without pomalidomide-dexamethasone (Pd) in cohort A and ND or D monotherapy in cohort B. The primary endpoint was safety. Secondary endpoints included minimal residual disease (MRD) negativity status, overall response rate (ORR), duration of response, and progression-free survival (PFS).

Results

Cohort A (n = 11) was terminated early due to safety concerns observed with immunomodulatory agents and checkpoint inhibitor combinations in other clinical trials. In the small number of patients treated in cohort A, no new safety concerns were observed but patients who received NDPd had numerically more grade 3/4 adverse events (AEs) and serious AEs compared with ND. Grade 3/4 AEs occurring in ≥ 1 patient in the ND group was anemia (3/6 patients); in the NDPd group, these were neutropenia (3/5 patients), upper respiratory tract infection (2/6 patients), and pneumonia (2/6 patients). In cohort B (n = 63), AE rates were similar between ND and D (any-grade: 87.8% vs 95.5%; grade 3/4: 53.7% vs 45.5%). Grade 3/4 AEs occurring in ≥ 1 patient in the ND group were neutropenia (19.5%), anemia (9.8%), thrombocytopenia (9.8%), and bronchitis (7.3%); in the D group these were anemia and pneumonia (both 9.1%). Immune-mediated AEs for ND were consistent with the known safety profile of nivolumab. In cohort A, all patients (5/5) receiving NDPd and 4/6 receiving ND achieved a response. In cohort B, the ORR with ND was numerically higher than D (22/41 [53.7%] vs 9/22 [40.9%]) and both groups had a median PFS of 6.6 months. ND also showed promising MRD negativity results (next-generation sequencing 10-5, 24.0%; next-generation flow 10-5, 22.2%).

Conclusion

NDPd demonstrated no new safety signals and encouraging efficacy despite its early termination. ND was well tolerated with a manageable toxicity and few AEs leading to discontinuation, and demonstrated a numerically higher ORR but equivalent PFS compared with D. Any clinical benefits to OS require a longer follow-up.

Clinical trial registration

https://clinicaltrials.gov/, identifier NCT01592370.
Utilizing the RE-AIM framework for a multispecialty Veterans Affairs Extension for Community Healthcare Outcomes (VA-ECHO) program 2018–2022
Authors: Mattox Elizabeth A. , Yantsides Konstantina E. , Germani Maureen Wylie , Parsons Elizabeth C.
Published: September 2023

VA-ECHO (Veterans Affairs -Extension for Community Healthcare Outcomes) provides live, synchronous, continuing education accredited, case-based learning. Sessions deliver up-to-date, evidence-based, practice-relevant, Veteran-focused learning to healthcare team members. The primary goal of VA-ECHO is to increase Veterans' access to high quality care by improving knowledge and skills among VA care providers. Utilizing the RE-AIM framework, descriptive statistics for 23 VA-ECHO programs regarding program effectiveness, adoption, implementation, and maintenance during a five-year period (2018–2022) are reported. VA-ECHO offered 1,462 sessions and 157,238 contact hours, engaging 17,642 participants from 837 VA-based sites (20% rural-based sites). Effectiveness includes information on number and diversity of programs, as well as reported impact on participants' practice. Adoption includes descriptive statistics, including comparison of growth and change compared to prior years. Implementation describes change in the program over time, including the number of specialties offered, and types of continuing education offered. Maintenance includes a narrative regarding sustainability. The discussion focuses on implementation and maintenance strategies the program has used to address participant and VA needs within the RE-AIM framework, including adjustments to the program, iterative qualitative improvement, sustainment strategies, and opportunities for future evaluation.
Case Report: Oral and fecal microbiota in a super-donor: the healthy microbiota paradigm for fecal transplantation
Authors: Ortiz-Olvera Nayeli , Fernández-Figueroa Edith A. , Argueta-Donohué Jesús , Miranda-Ortíz Haydee , Ruiz-García Erika
Published: September 2023

Despite the numerous fecal microbiota transplantation trials that have been carried out, knowledge about the actual composition of a “healthy microbiota” remains scarce. The aim of this research was to describe the differences in the composition of oral and fecal microbiotas in a super-donor. The microbiota analysis was done using next-generation sequencing of the V3 and V4 regions of the bacterial 16S rRNA gene. The biodiversity found in the mouth was very rich, with 56 species identified, and there was a predominance of the genera Veillonella, Haemophilus, and Streptococcus. It is worth mentioning the presence (2.33%) of Fusobacterium nucleatum in the mouth. In feces, the genera Bacteroides and Faecalibacterium predominated, with the species F. prausnitzii being the most abundant. This analysis shows that the diversity of the microbiota of a super-donor plays a fundamental role in the effectiveness of its product in fecal matter transplantation. This suggests that transplanted gut microorganisms have the ability to maintain or recover health in a dynamic process between the microbiota and the host. Our findings encourage further research which will result in the development of bacterial therapies in infectious and inflammatory diseases.
The high burden of erectile dysfunction among men living with HIV in northern Tanzania: a call for evidence-based interventions
Authors: Mbwambo Orgeness J. , Lyatuu Moses , Ngocho Geofrey , Abdallah Khadija , Godfrey Patricia , Ngowi Bartholomeo N. , Mremi Alex , Malindisa Evangelista , Amour Maryam , Ngocho James , Balandya Emmanuel , Kwesigabo Gideon , Manongi Rachel , Kidenya Benson R. , Mshana Stephen E. , Lyamuya Eligius F. , Sunguya Bruno F. , Bartlett John , Mmbaga Blandina Theophil , Mteta Alfred K.
Published: September 2023

Background

The extent of the burden of erectile dysfunction and its associated factors remains unclear. The aim of this study was to investigate the factors associated with ED and its prevalence among MLHIV in northern Tanzania.

Methods

A hospital-based, multi-center, cross-sectional study was conducted on MLHIV aged 18 years and above in northern Tanzania.

Outcome

The risk factors for ED and the prevalence of such risk factors among MLHIV was assessed and evaluated through a multivariate logistic regression analysis adjusted for depression symptoms using the Patient Health Questionnaire-9 (PHQ9) scale; anxiety disorders using the Generalized Anxiety Disorder Assessment (GAD-7); ART adherence; viral load; initial regimen date; ART regimen; and sexual risk behaviors.

Results

Data for 366 participants with a median age of 50 years (IQR 38–57 years) were available for analysis. Approximately three in four (74.6%) MLHIV had ED (of any severity), whereas 37.7% had mild ED. The majority (96.5%) of the participants had low testosterone, two in three (66.7%) had depressive symptoms, and close to half of the participants (48.4%) had anxiety. Age, lack of engagement in vigorous physical activity, depression, and self-reported good adherence to antiretroviral therapy (ART) were associated with ED in a multivariate logistic regression analysis (p=0.004, p =0.006, p=0.07, p=0.006, and p=0.004, respectively).

Conclusion

There is a high prevalence of ED among MLHIV in northern Tanzania. Erectile dysfunction should be regarded as one of the comorbidities associated with HIV and should be routinely screened for among MLHIV in CTC clinics.
Physical activity and sport practice to improve balance control of visually impaired individuals: a narrative review with future perspectives
Authors: Carretti Giuditta , Manetti Mirko , Marini Mirca
Published: September 2023

Visual disability negatively impacts balance, everyday self-efficacy, and mobility and often leads affected subjects to perceive physical exercise as a burdensome challenge thus discouraging them from practicing. Despite the well-proven benefits of regular physical activity in visually impaired people, especially addressing postural control, there are no specific guidelines and most of the available literature seems to be flawed by critical issues. Given the wide heterogeneity and the multidimensional needs of this population, a more realistic and target-specific perspective is needed in order to properly investigate and promote exercise practice and adherence for balance improvement. On this basis, through a critical overview of the recent literature, the present article aimed to enrich the current knowledge about this topic by providing innovative suggestions, both practical and methodological, and specifically deepening the disability-related deficits and peculiarities of different age ranges. Moreover, since a multidisciplinary approach is advisable when designing and leading exercise protocols tailored to visually impaired individuals, such innovative hints also highlighted the central role of the adapted physical activity specialist, hence contributing to foster its official professional recognition and involvement in this field.
Risk factors associated with the prevalence of Listeria monocytogenes in manured soils on certified organic farms in four regions of the United States
Authors: Chandler-Khayd Carolyn , Di Francesco Juliette , Baron Jerome N. , Ramos Thais De Melo , Aminabadi Peiman , Jay-Russell Michele T. , Haghani Viktoria , Millner Patricia D. , Pagliari Paulo H. , Hutchinson Mark , Kenney Annette , Hashem Fawzy , Martínez-López Beatriz , Bihn Elizabeth A. , Clements Donna P. , Shade Jessica B. , Sciligo Amber R. , Pires Alda F. A.
Published: September 2023

Introduction

Biological soil amendments, including raw or untreated manure, are currently used to improve soil fertility, especially in organic operations that prohibit use of synthetic fertilizers. However, addition of untreated manure may pose a risk of contamination of fresh produce by pathogens of public health significance, including Listeria monocytogenes. Organic growers follow United States Department of Agriculture (USDA) National Organic Program regulations for raw manure use, which stipulate that harvest should commence no earlier than 90- or 120-days post-application, depending on direct contact between the edible portion of the produce and the soil. To inform the protection that such time-intervals provide, this study explored the farm-level risk factors associated with L. monocytogenes prevalence in USDA-certified organic farm soils amended with untreated manures.

Methods

A longitudinal, multi-regional study was conducted on 19 farms in four states (California, Minnesota, Maine, and Maryland) over two growing seasons (2017 and 2018). Untreated manure, soil, irrigation water, and produce samples were collected and cultured for L. monocytogenes. Mixed effect logistic regression was used to investigate risk factors associated with L. monocytogenes prevalence in soil.

Results and Discussion

Results showed that multiple factors influenced the odds of a soil-positive sample, including temporal [year (OR = 0.19), sampling day (OR = 0.09–0.48)] and weather-related [temperature range (OR = 0.48)] variables, manure characteristics [season of application (OR = 0.04, summer), presence of L. monocytogenes (OR = 2.89) and other pathogens in manure (OR = 5.24)], farm management factors [water source (OR = 2.73, mixed), number of year-round staff (OR = 0.02)], and soil characteristics [concentration of generic Escherichia coli (OR = 1.45), moisture (OR = 0.46), organic matter (OR = 7.30), nitrate (OR = 3.07), potassium (OR = 0.09) and calcium (OR = 2.48)]. This study highlights the complexity of L. monocytogenes prevalence in soil and contributes science-based metrics that may be used when determining risk-mitigation strategies for pathogen contamination.
The prevalence, genetic diversity and evolutionary analysis of cachavirus firstly detected in northeastern China
Authors: Li Nuowa , Bai Yue , Yan Xin , Guo Zhiyuan , Xiang Kongrui , Yang Zaixing , Shangguan Haikun , Ge Junwei , Zhao Lili
Published: September 2023

Canine cachavirus is a novel parvovirus belonging to the genus Chaphamaparvovirus that was first detected in dogs in the United States. However, our knowledge of the prevalence and genetic characteristics of cachavirus is relatively limited. In this study, 325 canine fecal specimens collected from healthy and diarrheic dogs in northeastern China were screened with PCR. Twenty-two of the 325 (6.8%) samples were positive for cachavirus. The diarrhea samples showed high viral coinfection rates, and we detected coinfections with canine astrovirus (CaAstV) and cachavirus for the first time. A sequence analysis revealed that the Chinese cachavirus strains have point mutations in four consecutive amino acid codons relative to the original American strain. A codon usage analysis of the VP1 gene showed that most preferred codons in cachavirus were A- or T-ending codons, as in traditional canine parvovirus 2. A co-evolutionary analysis showed that cachavirus has undergone cospeciation with its hosts and has been transmitted among different host species. Our findings extend the limited cachavirus sequences available, and provide detailed molecular characterization of the strains in northeastern China. Further epidemiological surveillance is required to determine the significance and evolution of cachavirus.
The Mediation Effect of Attitude on the Association Between Knowledge and Self-Management Behaviors in Chinese Patients With Diabetes
Authors: Zhang Yu , Zhang Beibei , Chen Cunchuan , Feng Xia , Song Suhang , Wang Haipeng
Published: September 2023

Objective: This study aims to investigate the level of knowledge, attitude and self-management behaviors of diabetic patients, to explore the mediating role of attitude in the relationship between knowledge and self-management behaviors.

Methods: 900 diabetes patients were randomly selected from the eastern, central and western regions of Shandong Province, China, and recovered 863 valid questionnaires. Path analysis was used to examine the mediating role of attitude in the relationship between knowledge and self-management behaviors in patients with diabetes.

Results: The mean score (SD) of the diabetes self-management questionnaire (DSMQ) in this study was 35.01 (6.87). The direct effect value of knowledge level on self-management behaviors was 0.357, accounting for 62.09% of the total effect. The indirect effect value of knowledge on self-management behaviors through attitude was 0.218, accounting for 37.91%.

Conclusion: Level of knowledge has a significant direct impact on self-management behaviors and an indirect impact on self-management behaviors through attitude. Therefore, it is necessary to strengthen health education on diabetes to improve awareness, ameliorate attitudes toward diabetes, and change self-management behaviors.
Timing of Early Salvage Therapy for Patients With Biochemical Relapse of Prostate Carcinoma
Authors: Argalácsová Soňa , Vočka Michal , Čapoun Otakar , Lambert Lukáš
Published: September 2023

Between 25% and 33% of patients after radical prostatectomy experience a relapse of the disease. The risk of relapse increases in patients with risk factors up to 50%–80%. For a long time, adjuvant radiotherapy has been considered the standard of care. Four large prospective trials, that compared adjuvant and salvage radiotherapy in patients with biochemical relapse, showed the superiority of the adjuvant approach in biochemical and local relapse-free survival, but no consistent benefit in long-term endpoints (i.e., metastasis-free survival, overall survival, or carcinoma-specific survival) at the expense of increased urinary and bowel toxicity. Three large international studies comparing adjuvant and salvage radiotherapy paved the way toward early salvage radiotherapy. However, the optimal threshold of the PSA level (range of 0.2–0.5 ng/mL) for initiating early salvage radiotherapy remains unresolved and still poses a challenge in everyday clinical practice when balancing the need for early radiotherapy and the associated toxicity. Imprecise stratification of biochemical relaps patients according to the risk of clinical relapse drives efforts to find additional molecular biomarkers that would improve the timing of the salvage therapy.
One-Step Discrete Fourier Transform-Based Sinusoid Frequency Estimation under Full-Bandwidth Quasi-Harmonic Interference
Authors: Silva João Miguel , Oliveira Marco António , Saraiva André Ferraz , Ferreira Aníbal J. S.
Published: September 2023

The estimation of the frequency of sinusoids has been the object of intense research for more than 40 years. Its importance in classical fields such as telecommunications, instrumentation, and medicine has been extended to numerous specific signal processing applications involving, for example, speech, audio, and music processing. In many cases, these applications run in real-time and, thus, require accurate, fast, and low-complexity algorithms. Taking the normalized Cramér–Rao lower bound as a reference, this paper evaluates the relative performance of nine non-iterative discrete Fourier transform-based individual sinusoid frequency estimators when the target sinusoid is affected by full-bandwidth quasi-harmonic interference, in addition to stationary noise. Three levels of the quasi-harmonic interference severity are considered: no harmonic interference, mild harmonic interference, and strong harmonic interference. Moreover, the harmonic interference is amplitude-modulated and frequency-modulated reflecting real-world conditions, e.g., in singing and musical chords. Results are presented for when the Signal-to-Noise Ratio varies between −10 dB and 70 dB, and they reveal that the relative performance of different frequency estimators depends on the SNR and on the selectivity and leakage of the window that is used, but also changes drastically as a function of the severity of the quasi-harmonic interference. In particular, when this interference is strong, the performance curves of the majority of the tested frequency estimators collapse to a few trends around and above 0.4% of the DFT bin width.
VNIR-SWIR Spectroscopy, XRD and Traditional Analyses for Pedomorphogeological Assessment in a Tropical Toposequence
Authors: Novais Jean J. , Poppiel Raúl R. , Lacerda Marilusa P. C. , Demattê José A. M.
Published: September 2023

Tropical climate conditions favor landscape evolution and the formation of highly weathered soils under different pedogenic processes due to certain differential properties. Traditional analysis coupled with VNIR-SWIR reflectance spectroscopy and X-ray diffractometry (XRD) analyses can reveal such characteristics. Several researchers cited throughout this study already discussed the possible applications of analyses in this field. All agree that integrated knowledge (holistic) can drive the future of the soil sciences. However, few refer to the potential of soil spectroscopy in deriving pedogenetic information. Thus, this paper aimed to assess pedomorphogeological relationships in a representative toposequence of the Brazilian Midwest using traditional analyses and geotechnologies. We performed landscape observations and soil sampling in the field. The laboratory’s physical, chemical, spectral, and mineralogical determinations supported the soil classification according to the World Reference Basis (WRB/FAO) system. Based on the analysis results, we divided five profiles into two soil groups (highly and slightly weathered soils) using Pearson’s correlation and hierarchical clustering analysis (HCA). Traditional analyses determined the diagnostic attributes. Spectroscopic readings from 0.35 to 2.5 µm wavelengths and XRD supported identifying soil attributes and properties. Finally, all soil classes were correlated according to correspondent reflectance spectra and primary pedological attributes. There was a strong correlation between spectral oxide features and X-ray diffraction peaks. The HCA based on oxide content and mineral composition validated the previous soil grouping. Thus, we could assess the pedomorphogeological relationships through VNIR-SWIR spectroscopy, XRD, and traditional analyses concerning pedogenic processes through their correlation with soil properties resulting from these processes. However, periodic measurements are required, making orbital sensing a continuous data source for soil monitoring.
Effects of Crushing and Grinding on the Porosity of Hardened Cement Paste
Authors: Bouarroudj Mohamed ElKarim , Rémond Sébastien , Cazacliu Bogdan , Potier Guillaume , Courard Luc , Bulteel David
Published: September 2023

The objective of this paper was to study the impact of crushing and grinding on the porosity of hardened cement paste, which is responsible for the high values of recycled concrete aggregate (RCA) water absorption. Hardened cement pastes with three different water to cement ratios have been crushed in one to three steps with a jaw crusher to produce aggregate larger than 2 mm and ground with a disc crusher in order to produce particles lower than 150 µm. Water absorption tests and mercury intrusion porosimetry (MIP) were performed for the different resulting sizes. It was observed that the crushing procedure did not significantly affect the porosity of the aggregate. However, MIP performed on the powders showed differences in the pore size distribution compared with the monolith. This can better be attributed to a modification of the surface roughness of the particles than to a modification of their porosity. In all cases, the water absorption rate was the highest during the first 1 min after soaking in water. It was also observed that the morphology of the particles changed from a step of crushing to another.
Assessment of Bioactive Compounds in Red Peppercorns (Piper nigrum L.) for the Development of Red Peppercorns Powder
Authors: Lay Sovannmony , Sen Sochetra , Houng Peany
Published: September 2023

Red pepper powder is used as a spice added to various types of foods to improve the spiciness and aroma of foods. The unique aroma and spiciness of red pepper are related to the contents of bioactive compounds, including alkaloids, phenolic compounds, terpenes, and flavonoids. These phytochemical compounds have extensively provided many biological activities, such as antioxidant, anti-inflammatory, and antimicrobial. The assessment of bioactive compounds in red pepper is crucial to evaluate the quality of red pepper powder. Therefore, the objective of this study aimed to analyze total phenolic and total flavonoid compounds for further red peppercorn powder application. To assess the contents of bioactive compounds, Response Surface Methodology (RSM) with Box–Behnken Design (BBD) was applied to design the experiment and analyze the data. Furthermore, extraction conditions such as extraction time (30 to 150 min), temperature (35 to 65 °C), and solid-to-solvent ratio (0.5:10 to 0.5:20 g/mL) were investigated for their effects on the yield of total phenolic and total flavonoid contents. The result of this study found that all extraction parameters significantly affected the extraction yields of phenolic and flavonoid compounds. The aroma and taste of red pepper powder can be adjusted by changing extraction conditions such as temperature, time, and solid-to-solvent ratio because changing these conditions allowed the bioactive compounds to be extracted from red pepper at different concentrations. Overall, the assessment of bioactive compounds in red peppercorns holds significant importance for their application as red peppercorn powder.
On the ac Measurements of the Electrical Conductivity of Dilute Colloidal Electrolytes
Authors: Chikina Ioulia , Nakamae Sawako , Varlamov Andrey
Published: September 2023

The details of ac-conductivity measurements in a colloidal electrolyte cell with flat control gate electrodes are discussed. The use of impedance diagnostics in studies of transport phenomena in such systems requires caution in the definition of the thickness of the screening accumulation layers that appear along the metal-electrolyte interfaces. The value of this characteristic length λ0 critically depends on the volume fraction ϕ⊙ of colloidal particles in the bulk of the electrolyte. Accounting for the dependence λ0(ϕ⊙) makes it possible to consistently explain the large discrepancy in the available experimental data regarding the influence of the colloidal fraction on the effective conductivity of the colloidal suspension.
Investigation on the Crashworthiness Performance of Thin-Walled Multi-Cell PLA 3D-Printed Tubes: A Multi-Parameter Analysis
Authors: Hidayat Dony , Istiyanto Jos , Sumarsono Danardono Agus , Kurniawan Farohaji , Ardiansyah Riki , Wandono Fajar Ari , Nugroho Afid
Published: September 2023

The effect of printing parameters (nozzle diameter, layer height, nozzle temperature, and printing speed), dimensions (wall thickness), and filament material on the crashworthiness performance of 3D-printed thin-walled multi-cell structures (TWMCS) undergoing quasi-static compression is presented. The ideal combination of parameters was determined by employing the Signal-to-Noise ratio (S/N), while Analysis of Variance (ANOVA) was utilized to identify the significant parameters and assess their impact on crashworthiness performance. The findings indicated that the ideal parameters for the specific energy absorption (SEA) consisted of a nozzle diameter of 0.6 mm, layer height of 0.3 mm, nozzle temperature of 220 °C, printing speed of 90 mm/s, wall thickness of 1.6 mm, and PLA(+) filament material. Afterward, the optimal parameters for crushing force efficiency (CFE) included a nozzle diameter of 0.8 mm, layer height of 0.3 mm, nozzle temperature of 230 °C, print speed of 90 mm/s, wall thickness of 1.6 mm, and PLA(ST) filament material. The optimum parameter to minimize manufacturing time is 0.3 mm for layer height and 90 mm/s for printing speed. This research presents novel opportunities for optimizing lightweight structures with enhanced energy absorption capacities. These advancements hold the potential to elevate passenger safety and fortify transportation systems. By elucidating the fundamental factors governing the crashworthiness of thin-walled multi-cell PLA 3D-printed tubes, this study contributes to a deeper understanding of the field.
“I Believe More in the Ability of the Small Person to Make Big Changes”: Innovation and Social Entrepreneurship to Promote Public Health in Israel
Authors: Dopelt Keren , Mordehay Nila , Goren Shir , Cohen Aviya , Barach Paul
Published: September 2023

Social entrepreneurship has grown worldwide in recent decades as it attempts to create and implement innovative solutions to social and environmental issues through business strategies. The aim of this study was to explore what motivates public health social entrepreneurs to act, the challenges and barriers they face, achievements, and competencies required for success. As such, we interviewed 15 social entrepreneurs in Israel. Budget issues, regulatory barriers, and struggles against powerful companies were the frequent barriers to success. The interviewees indicated several achievements at the health policy level by positioning and becoming an authority in the field, positively influencing other people’s lives. They highlighted the importance of creativity, determination and courage, leadership, and the ability to persevere in the face of overwhelming adverse odds as essential for the social entrepreneur’s success. Social entrepreneurship in public health is essential when struggling with health disparities. Nevertheless, recognizing that social entrepreneurship is not a substitute for methodological government planning and accountability is crucial.
Synchronization of Fractional-Order Delayed Neural Networks Using Dynamic-Free Adaptive Sliding Mode Control
Authors: Roohi Majid , Zhang Chongqi , Taheri Mostafa , Basse-O’Connor Andreas
Published: September 2023

In this work, a dynamic-free adaptive sliding mode control (adaptive-SMC) methodology for the synchronization of a specific class of chaotic delayed fractional-order neural network systems in the presence of input saturation is proposed. By incorporating the frequency distributed model (FDM) and the fractional version of the Lyapunov stability theory, a dynamic-free adaptive SMC methodology is designed to effectively overcome the inherent chaotic behavior exhibited by the delayed FONNSs to achieve synchronization. Notably, the decoupling of the control laws from the nonlinear/linear dynamical components of the system is ensured, taking advantage of the norm-boundedness property of the states in chaotic systems. The effectiveness of the suggested adaptive-SMC method for chaos synchronization in delayed fractional-order Hopfield neural network systems is validated through numerical simulations, demonstrating its robustness and efficiency. The proposed dynamic-free adaptive-SMC approach, incorporating the FDM and fractional Lyapunov stability theorem, offers a promising solution for synchronizing chaotic delayed FONNSs with input saturation, with potential applications in various domains requiring synchronization of such systems.
MYD88 Wild Type in IgM Monoclonal Gammopathies: From Molecular Mechanisms to Clinical Challenges
Authors: Bagratuni Tina , Papadimou Alexandra , Taouxi Kostantina , Dimopoulos Meletios A. , Kastritis Efstathios
Published: September 2023

High frequencies of MYD88L265P mutation are observed in IgM monoclonal gammopathies, and specifically in Waldenström macroglobulinemia (WM), indicating this mutation as a potential disease biomarker. Given the fact that MYD88L265P mutation has been described as a key driver mutation, has increased our understanding of the biology behind MYD88 signaling and helped us to identify the functional components which could be targeted. On the other hand, the absence of the MYD88L265P mutation in patients with IgM monoclonal gammopathies has been associated with a higher risk of transformation to aggressive lymphomas, resistance to several therapies, and shorter overall survival. The present review focuses on the molecular mechanisms that shape the signaling pattern in MYD88WT cells, as well as on the clinical implications and therapeutic challenges of WM patients that harbor the MYD88WT genotype.
“In Vitro” Ovule Culture to Improve Genetic Variability in Hydrangea macrophylla
Authors: Nesi Beatrice , Ghiselli Lisetta , Gori Massimo , Natale Roberto , Tomiozzo Regina , Mansuino Andrea , Biricolti Stefano
Published: September 2023

In flowering plants, such as Hydrangea macrophylla, the main breeding objective is to increase genetic variability in ornamental traits. This study investigates in vitro techniques, through ovule culture, to overcome the hybridization barriers and increase the efficiency of crossing in Hydrangea macrophylla in which breeding has been hampered by a fairly long breeding cycle and lack of information about its genetic resources. Two different types of media were compared, Gamborg B5 and Murashige and Skoog basal salts, to verify the germination rate of immature ovules in different intraspecific crosses. The germination rate and viability of the seedlings were influenced by the parental genotypes in the different combinations of crossing, highlighting, in some cases, the poor compatibility between some of them. The crossing combination “Parental A × Parental B”, showed the highest germinated ovules percentage (78.3%). The media used seem to less affect the ovule germination while mainly influencing the development and growth of the young seedlings and in particular the number of leaves, the branching attitude, and root length, with the Gamborg medium determining up to a 30% increase, compared to MS medium. In addition, we tested the effectiveness of using SSR markers to assess the parentage of the putative hybrids even though only three out of twelve SSR markers showed allelism. Although the number of SSR markers was low, they were allowed to profile the parentage according to Mendelian laws.
Exercise Cardiac Load and Autonomic Nervous System Recovery during In-Season Training: The Impact on Speed Deterioration in American Football Athletes
Authors: Renaghan Eric , Wittels Harrison L. , Feigenbaum Luis A. , Wishon Michael Joseph , Chong Stephanie , Wittels Eva Danielle , Hendricks Stephanie , Hecocks Dustin , Bellamy Kyle , Girardi Joe , Lee Stephen , Vo Tri , McDonald Samantha M. , Wittels S. Howard
Published: September 2023

Fully restoring autonomic nervous system (ANS) function is paramount for peak sports performance. Training programs failing to provide sufficient recovery, especially during the in-season, may negatively affect performance. This study aimed to evaluate the influence of the physiological workload of collegiate football training on ANS recovery and function during the in-season. Football athletes recruited from a D1 college in the southeastern US were prospectively followed during their 13-week “in-season”. Athletes wore armband monitors equipped with ECG and inertial movement capabilities that measured exercise cardiac load (ECL; total heartbeats) and maximum running speed during and baseline heart rate (HR), HR variability (HRV) 24 h post-training. These metrics represented physiological load (ECL = HR·Duration), ANS function, and recovery, respectively. Linear regression models evaluated the associations between ECL, baseline HR, HRV, and maximum running speed. Athletes (n = 30) were 20.2 ± 1.5 years, mostly non-Hispanic Black (80.0%). Negative associations were observed between acute and cumulative exposures of ECLs and running speed (β = −0.11 ± 0.00, p < 0.0000 and β = −0.15 ± 0.04, p < 0.0000, respectively). Similarly, negative associations were found between baseline HR and running speed (β = −0.45 ± 0.12, 95% CI: −0.70, −0.19; p = 0.001). HRV metrics were positively associated with running speed: (SDNN: β = 0.32 ± 0.09, p < 0.03 and rMSSD: β = 0.35 ± 0.11, p < 0.02). Our study demonstrated that exposure to high ECLs, both acutely and cumulatively, may negatively influence maximum running speed, which may manifest in a deteriorating ANS. Further research should continue identifying optimal training: recovery ratios during off-, pre-, and in-season phases.
Utilisation Potential of Mechanical Material Loads during Grinding by Means of a Novel Tool Concept
Authors: Eich Marco , Meyer Daniel , Heinzel Carsten
Published: September 2023

The objective of this work is to improve the surface and subsurface properties of steel parts by means of a new grinding tool concept featuring nearly spherical grains in an elastic bonding system and to uncover the underlying mechanisms leading to the intended improvement of surface integrity. The resulting workpiece topography and subsurface properties, such as residual stresses, are evaluated to characterise and assess the potential of this novel tool concept. Micrographs and EBSD images are also analysed. The results show increased mechanical process loads and resulting favourable subsurface properties in terms of mechanically induced plastic deformation and compressive residual stresses, revealing the high potential of spherical grains in an elastic bonding system.
The Peculiarities of the German Uranium Project (1939–1945)
Authors: Popp Manfred , de Klerk Piet
Published: September 2023

An analysis of the peculiarities of the German Uranium Project (1939–1945) reveals that it was, in many ways, different from what one would expect. There was no work at all on a possible bomb, nor on plutonium. The reactor experiments were limited to subcritical systems and did not attempt to achieve the proclaimed goal of a self-sustaining chain reaction. The so-far identified deficits (lack of interest in Nazi circles, mismanagement, scientific mistakes, and deteriorating work conditions during the war) are relevant but not sufficient for explaining the peculiarities. We deduce that the scientists involved, and even the Heereswaffenamt (army ordnance), shied away from making progress, not only towards a bomb but even towards a reactor. They did not fail; they rather renounced a possible success in order not to provoke political interest in the development of a bomb.
Europeanised Attitudes, Nationalised Communication? Evidence on the Patterns behind Political Communication Output in Brussels
Authors: Plavec Jan Georg , Pfetsch Barbara
Published: September 2023

Studies of a communication deficit in the European Union (EU) have hardly taken a systematic look at the site where most of the political communication output is being created: within the elite bubble of EU politicians and correspondents in Brussels. This study builds on the communication culture approach to describe and explain the basic attitudinal patterns of EU politicians and journalists who critically shape the political communication output coming out of Brussels that is being consumed by European citizens. Based on a survey with more than 300 participating politicians and journalists, this study demonstrates that the internationalised communication context in Brussels reduces differences between the attitudes of actors from professional and national groups. We demonstrate that there is a tendency toward common elitist attitudes, complemented by a highly negative view of the public and a cynical mode of political communication. However, we observe predominantly national contact networks in Brussels and partly differing attitudes among some sub-groups of politicians and journalists, reflecting the partly conflicting national configurations of the European political and media system and the principal-agent relationships of EU politicians and journalists with their constituencies and media outlets.
Understanding the Patient Perspective When Designing Future Rehabilitation Interventions after Hip or Knee Replacement Surgery—A Patient and Public Involvement Exercise
Authors: Gavin James P. , Burgess Louise C. , Immins Tikki , Wainwright Thomas W.
Published: September 2023

Background and Objectives: Following discharge from hospital, there can be variability in the rehabilitation of patients who have undergone total hip or knee replacement surgery. We invited patients who had had hip or knee replacement surgery to take part in patient and public involvement sessions to help us understand their recovery needs and how rehabilitation services could potentially be improved to meet these needs better. Materials: Patients (n = 14) were invited to one of two patient advisory group sessions which took place in a university setting. Results: Feedback from patients highlighted the need for an inclusive, evidence-based intervention that would benefit patients experiencing all levels of pain, with differing motivations for recovery. Patients desired social support with others who have had similar surgery to reduce the burden of isolation during rehabilitation. Furthermore, patients valued the involvement of their partners and carers in their rehabilitation, to provide social support and guidance on recovery. Patients also expressed a need for consistent information and expert guidance on all aspects of their recovery. Conclusions: These findings can be used to guide the design of rehabilitation interventions following hip and knee replacement and ensure that patient perspectives inform future practice.
Solvent-Controlled Morphology of Zinc–Cobalt Bimetallic Sulfides for Supercapacitors
Authors: Zang Xiaobei , Tang Xiaoqi , Liang Liheng , Liu Xuhui , Zhang Xiaobin , Ma Xingdong , Liu Guoshun , Li Chao , Cao Ning , Shao Qingguo
Published: September 2023

Bimetallic sulfides offer high theoretical specific capacitance and good stability as electrode materials due to their diverse redox reactions, larger specific surface areas, and better conductivity. The morphology of the electrode material is an important influencing factor for the electrochemical properties. Herein, a series of ZnCoS electrode materials with different morphologies were prepared by varying the solvent in the solvothermal reaction, and the effects of different microstructures on the electrochemical properties of ZnCoS were investigated. The ratio of water and ethanol in the solvent was controlled to modulate the microstructure of the as-prepared ZnCoS materials. XRD and XPS revealed the physical and chemical structure of the ZnCoS materials. SEM and TEM observations showed that the microstructure of ZnCoS transformed from one-dimensional wires to two-dimensional sheets with increasing amounts of ethanol. The maximum specific capacitance of the as-prepared ZnCoS materials is 6.22 F cm−2 at a current density of 5 mA cm−2, which is superior to that of most previously reported bimetallic sulfides. The enhanced electrochemical performance could be ascribed to its sheet-assembled spherical structure, which not only shortens the path of ion diffusion but also increases the contact between surface active sites and the electrolyte. Moreover, the spherical structure provides numerous void spaces for buffering the volume expansion and penetration of the electrolyte, which would be favorable for electrochemical reactions. Furthermore, the ZnCoS electrodes were coupled with activated carbon (AC) electrodes to build asymmetric supercapacitors (ASCs). The ASC device exhibits a maximum energy density of 0.124 mWh cm−2 under a power density of 2.1 mW cm−2. Moreover, even under a high-power density of 21 mW cm−2, the energy density can still reach 0.055 mWh cm−2.