bluuebunny/crossref_metadata_2025 huggingface dataset:
Corrosion Inhibition Performance of an Ionic Liquid for Carbon Steel in chloride Solutions: Adsorption, Thermodynamic, and Quantum Chemical Investigations
Authors: Abbas Mohamed A. , Ismail Amr S. , Zakaria K. , El-Shamy A. M. , Abedin sherif El
Published: May 2022

The corrosion inhibition performance of the ionic liquid 1-butyl-3-methylimidazolium trifluoromethyl sulfonate ([BMIm]TfO) for carbon steel in 3.5% NaCl solutions was demonstrated. The study comprised electrochemical, adsorption, and quantum chemical investigations. The results manifested that [BMIm]TfO can be considered a promising corrosion inhibitor and the inhibition efficacy intensifies as the concentration rises. The observed inhibitive effect can be correlated to the adsorption of the ionic liquid species and the creation of protecting films on the surface. The mode of adsorption follows the Langmuir adsorption isotherm. The polarization results showed that the ionic liquid [BMIm]TfO functions as a mixed inhibitor. Reliance of the corrosion influence on the temperature in the existence and absence of [BMIm]TfO was demonstrated in the temperature range of 303–333 K using polarization data. Activation parameters were determined and discussed. The observed inhibition performance of [BMIm]TfO was correlated with the electronic properties of the ionic liquid using a quantum chemical study.
Real time and spatiotemporal quantification of pH and H2O2 imbalances with a multiplex SERS nanosensor
Authors: Xiao Can , Izquierdo-Roca Victor , Rivera-Gil Pilar
Published: May 2022

Oxidative stress is involved in many aging-related pathological disorders and is the result of a defective cellular management of redox reactions. Particularly, hydrogen peroxide, H2O2 is a major byproduct and a common oxidative stress biomarker. Monitoring H2O2 dynamics and a direct correlation to diseases remain still a challenge due to the complexity of redox reactions. Sensitivity and specificity are a major drawback for H2O2 sensors regardless their readout. Luminiscent boronate-based probes such as 4-MPBA are emerging as the most effective quantitation tool due to their specificity and sensitivity. Problems associated to these probes are limited intracellular sensing, water solubility, selectivity, and quenching. We have synthesized a boronate-based nanosensor with a SERS readout to solve these challenges. Furthermore, we found out that environmental pH gradients, as found in biological samples, affect the sensitivity of boronate-based sensors. When the sensor is in an alkaline environment, the oxidation promoted by H2O2 is more favored than in an acidic environment. This leads to different H2O2 measurements depending on pH. To solve this issue, we synthesized a multiplex nanosensor able to concomitantly quantify pH and H2O2. Our nanosensor first measures the local pH and based on this value, provide the amount of H2O2. It seems that this pH-dependent sensitivity effect applies to all boronic acid-based probes. We tested the multiplexing ability by quantitatively measuring intra-and extra-cellularly pH and H2O2 dynamics under physiological and pathological conditions on healthy cells and cells which H + and/or H2O2 homeostasis has been altered.
The impact of cytotoxic T cells on the prognosis and tumor microenvironment of osteosarcoma
Authors: Liu Yongfu , Guo Guancheng , Liu Baochi , Wang Limin
Published: May 2022

Background: Cytotoxic T lymphocytes (CTLs) is the mainstay to kill cancer cells. Little was known about its impact in osteosarcoma. This study aimed the reveal its functional and prognostic role in osteosarcoma.Methods: The gene expression data from 88 osteosarcoma patients in the TARGET programs were downloaded, and the clinical characteristics of these patients including overall survival and vital status were also collected. The ssGSEA was applied to generate the CTL score for each sample based on CTL signature, and osteosarcoma cases were divided to the high and low CTL score cohorts. Differentially expressed genes (DEGs) between the two groups were identified, and an optimal CTL-related risk model was generated by LASSO Cox regression analyses. CIBERSORT was used to evaluate the amounts of 22 tumor infiltrating immune cells in the microenvironment. Results: CTL score can predict OS in osteosarcoma patients. GSEA indicated several pro-inflammatory pathways with significant enrichment in the high-CTL infiltration cluster. The proportion of γδ T cells, and M1 macrophages were notably higher in high CTL score subgroup, while the naïve B cells, resting NK cells, and M0 macrophages were significantly lower. Furthermore, DEGs between the two groups were applied to univariate and LASSO Cox regression analysis to build a six-gene risk model. Kaplan-Meier analysis and ROC curves further confirmed the predictive values of the risk model.Conclusions: CTLs were predictive of overall survival in osteosarcoma and can reflect anti-cancer inflammatory state. The predictive capability of the six-gene risk model is high.
Relative importance of ecophenotypic plasticity and sexual dimorphism in determining shell shape in the Amazonian freshwater mussel Castalia ambigua (Unionida: Hyriidae) along a hydrological gradient
Authors: Simeone Diego , Tagliaro Claudia Helena , Lima Jeovana Oliveira , Beasley Colin Robert
Published: May 2022

Shell shape variation of the freshwater mussel Castalia ambigua in relation to environmental and genetic drivers remains unresolved in South America. Along an increasing upstream to downstream hydrological gradient in the Caeté River, eastern Amazon, Brazil, we evaluated two co-occurring morphotypes of C. ambigua: the first is elongated and compressed; the second is rounded and inflated. We performed multivariate shape analysis on the lateral view of the right valve and the umbonal view, to identify potential ecophenotypic trends. We also investigated whether the degree of shell inflation was associated with sexual dimorphism. Castalia ambigua shell shape differed along the hydrological gradient and between morphotypes. However, in high hydraulic energy habitats the two morphotypes tend to converge. Inflated shells of C. ambigua corresponded to female specimens, implying that shell shape variation in low hydraulic energy habitats was associated with sexual dimorphism. We found strong evidence of ecophenotypic plasticity and variation in sexual dimorphism in the freshwater mussel C. ambigua, associated with a hydrological gradient. Ecophenotypic plasticity appears to override sex-linked shell shape determination in high energy habitats. Differences in shell shape and the identification of ecomorphotypes are important for management efforts, such as protecting the specific habitats associated with both morphotypes.
Asymptomatic deep venous thrombosis in hospitalized acutely ill medical patients: risk factors and therapeutic implications
Authors: Loffredo Lorenzo , Vidili Gianpaolo , Sciacqua Angela , Cogliati Chiara , Giulio Rosella Di , Bernardini Sciaila , Ciacci Paolo , Pietrangelo Antonello , Orlando Federica , Paraninfi Aurora , Boddi Maria , Minno Giovanni Di , Falsetti Lorenzo , Lodigiani Corrado , Santoliquido Angelo , Ettorre Evaristo , Pignatelli Pasquale , Arezzo Maria Felice , Harenberg Job , Violi Francesco
Published: May 2022

Background: Acutely ill medical patients experience deep venous thrombosis (DVT) during the hospitalization, however the time course of DVT is still unclear. Objectives: To evaluate risk factors in acutely ill hospitalized medical patients for asymptomatic DVT (ADVT) and symptomatic DVT (SDVT) within 48 hours from admission and at discharge and comparing prophylaxis treatment with (group A) and without (group B) low-molecular weight heparin (LMWH) Patients/Methods: Consecutive acutely ill medical patients underwent duplex color compression ultrasonography (CUS) of proximal lower limb veins within 48 hours from admission and at discharge to screen for ADVT and to document SDVT. Primary end-point of the multicentric study was the incidence of all DVT. Biographical characteristics at hospitalization, D-Dimer and DD-improve score at entry and at discharge were analyzed by univariate and multivariate analysis to identify variables associated with DVT and compared between groups.Results: Of 2,100 patients (1002 females, 998 males, age 71±16) included 58 (2.7%) (31 females. 27 males, age 77±14) had ADVT at admission. A binary logistic regression analysis showed that age (O.R.: 1.03, 95% C.I. 1.007-1.05, p=0.008), thrombophilia (O.R.: 10,95% C.I. 3-34, p<0.001) and active cancer (O.R.: 2.3, 95% C.I. 1.3-4.1, p=0.005) were independently associated with ADVT at admission. The median length of hospitalization was 10 days [interquartile range: 6-15 days]. During the hospital stay, 6 patients (0.3%) with a negative CUS at admission experienced DVT (2 SDVT and 4 ADVT). Risk factors were not different on admission of all patients and of patients with DVT (n=64) and when compared to discharge. In the subgroup of patients (n=1118), in whom that performed D-dimer was measured at admission, elevated D-Dimer and higher IMPROVE-DD score were associated with ADVT at admission (n=37) and with all DVT (n=42) at discharge. Patients of group A presented the following risk factors compared to patients of group B: older age, reduced mobility, acute infection, kidney failure, heart or respiratory failure, previous myocardial infarction or stroke and hypertension. Conclusions: The incidence of ADVT and of SDVT was high (3%) upon admission of acutely ill medical patients upon hospitalization. Advanced age, active cancer, thrombophilia, elevated D-dimer and IMPROVE-DD score greater than 2.5 were risk factors for ADVT should analyzed upon hospitalization for decision of treatment with LMWH. The benefit of therapeutic dose of anticoagulation needs to be investigated in patients with ADVT and specific risk factors. Trial registration: NCT03157843
Bile Leakage after Hepatic Resection for Hepatocellular Carcinoma: Does it Impact the Short- and Long-Term Outcomes?
Authors: Shehta Ahmed , Farouk Ahmed , Elghawalby Ahmed , Said Rami , Nakeeb Ayman El , Aboelenin Ahmed , Elshobary Mohamed , Fouad Amgad
Published: May 2022

Purpose:Bile leakage (BL) is one of the commonest morbidities after hepatic resection for hepatocellular carcinoma (HCC). The current study was conducted to evaluate the incidence and different predictive factors for BL after hepatic resection for HCC, and to evaluate of the impact of BL on the long-term survival outcomes.Methods:We reviewed the patients’ data who underwent hepatic resection for HCC during the period between June 2010 and June 2019.Results:293 patients were included in the study. BL occurred in 17 patients (5.8%). More Child-Pugh class B patients were found in BL group. There were no significant differences between the two groups except for tumor site, macroscopic portal vein invasion, extent of liver resection, Pringle maneuver use, intraoperative blood loss, and transfusions. Longer hospital stay, higher grades of posthepatectomy liver failure, and abdominal collections were noted in BL group.After median follow-up duration of 17 months (4-110 months), there were no significant differences between BL and Non-BL group regarding overall survival (Log Rank, p = 0.746) and disease-free survival (Log Rank, p = 0.348).In multivariate analysis, Child-Pugh class, macroscopic portal vein invasion, liver resection extent (minor/major), and Pringle’s maneuver use were the only significant predictors of BL.Conclusion:BL did not significantly impair the long-term outcomes after hepatic resection for HCC. Child-Pugh class, macroscopic portal vein invasion, liver resection extent (minor/major), and Pringle’s maneuver use were the main risk factors of BL in the current study.
Metformin mitigates early brain injury after subarachnoid hemorrhage primarily by increasing SIRT1 and inhibiting inflammation factors
Authors: Zhang Zhong-hua , He Wei-zhen , Zhou Xiao-ming , Zhang Xin
Published: May 2022

Clinically, early brain injury (EBI) which refers to the acute injuries to the whole brain in phase of the first 72 h following subarachnoid hemorrhage (SAH), is intensely investigated to improve neurological and psychological function. It had been revealed that metformin (Met) possesses extensive functions, all can be showed in anti-inflammatory, antiapoptotic and anti-tumor activities. Here, to investigate the anti-inflammatory effect of Met, patients with SAH undergoing embolization of intracranial aneurysm in the Neurosurgery Department of the Jinling Hospital, were reviewed for a clinical retrospective analysis from January 2013 to November 2019. Meanwhile, we examined the effects of Met on the inflammatory factors and apoptosis after SAH and the explanation mechanisms of action in vivo. Met administration 2days before SAH ameliorated cerebral inflammation, brain edema, and neuronal death and improved neurologic function. Collectively, these results indicate that Met reduces the inflammatory response and alleviates early brain injury after SAH, primarily by increasing SIRT1 levels and inhibiting inflammation factors.
Risk Factors for Loss of Follow-Up after Asynchronous Dermatology eConsult Concerning for Skin Cancer
Authors: Himed Sonia , Levine Edward , Trinidad John , Kaffenberger Benjamin
Published: May 2022

Asynchronous electronic consultations (e-consults) can be a useful tool for the screening of cutaneous lesions, but may offer a malpractice risk. We characterized factors affecting initial eConsult office follow-up in a cohort of patients with documented neoplasm of uncertain behavior. Patients with an ICD 10 code of neoplasm with uncertain behavior (D48.5) at The Ohio State University that received an E-consult order from May 2017 to May 2021 were queried. Information collected included patient demographics, status of follow-up in-office appointment, referral status, and health care utilization. In-office follow-up appointments were defined as completed, cancelled/no-show or no-contact. 667 patients with a diagnosis of D48.5 were identified as having completed an eConsult. 427 (64%) patients had a documents phone/electronic message notifying the patient of the results of the eConsult. Year of encounter (0.88 [0.79–0.97]) and number of previously completed ambulatory visits (0.86 [0.77–0.96]) were significantly associated with documentation of phone/electronic message in the univariate and multivariate model. 429 (84%) patients had a dermatology office follow-up encounter while 82 (16%) had no appointment scheduled. Language spoken, referral status and race were significant in the univariate model, though race was the only significant variable in the multivariate model (p<0.003).Asynchronous electronic consults to assess possible cutaneous neoplasms is an important tool for population screening of skin cancer. Dermatologists and health systems implementing an eConsult model for screening purposes should be aware of risk factors for loss of follow-up. Additional systems need to be implemented to ensure minorities and non-native English speakers are obtaining adequate dermatologic care.
Comparison of Trajectories of Depressive Symptom Dimensions through Index Electroconvulsive Therapy in Major Depressive Disorder
Authors: Yang Jae-Won , Kim Yang Tae , Lee Hojun , Jung Sung-Won
Published: May 2022

BackgroundsStudies to date detailing trajectories of depressive symptom dimensions in patients undergoing index electroconvulsive therapy (ECT) have been small in number; many studies have focused on the total score of the rating scale. This Study aimed to investigate the trajectories of depressive symptom dimensions and the time point when the difference in improvement of depressive symptom dimensions between the remitters and non-remitters appeared.MethodsA retrospective analysis was performed on 80 patients with major depressive disorder who underwent index ECT. The Hamilton Depression Rating Scale-17 was used, and each item was clustered into four dimensions (depression, anxiety, insomnia, and somatic symptoms). Dimensions were standardized to a T-score and assessed at five time points (pre-ECT, and after the third, sixth, ninth, and twelfth ECT session). The data were analyzed using the generalized estimating equations method.ResultsIn the total sample, the T-scores of all dimensions continued to reduce significantly until the sixth session. The reduction of the depression dimension T-score was prolonged until the ninth session. Significant differences in the amount of improvement between remitters and non-remitters appeared after the sixth session. The depression dimension showed a greater reduction in T-score than the other dimensions throughout the entire index ECT course.ConclusionsThe depression dimension improved more than other dimensions in patients undergoing ECT. It may be beneficial to administer at least six treatments to avoid early termination of ECT and relapse. Managing other depressive symptoms, such as insomnia, could play a significant role in improving therapeutic effect. Further studies examining depression symptoms using more accurate scales and specifying the neuronal circuits associated with each dimension are necessary.
Lung Involvement in Children with Newly Diagnosed Rheumatic Diseases: Characteristics and Associations
Authors: huang hua , Hu Yabin , Wu Yufen , Ding Fei , Xu Xuemei , Jin Yingying , Jin Yanliang , Bao Yixiao
Published: May 2022

Background: Pulmonary complications of rheumatic diseases may cause functional impairment and increase mortality. However, reports regarding detection of lung involvement in children with treatment-naive, newly diagnosed rheumatic diseases are scarce. Herein, we aimed to describe the characteristics of such patients and explore the association between lung involvement and rheumatic disease.Methods: From January 2019 to June 2021, 48 pediatric patients with treatment-naive, newly diagnosed rheumatic diseases at our department were included with pulmonary function tests (PFTs) and high-resolution computed tomography (HRCT) findings, and 51 age-matched healthy controls were examined based on PFTs. Univariate and multivariable logistic regression analyses were used to investigate the clinical characters and laboratory parameters associated with lung involvement in these patients.Results: Asymptomatic patients had a faster respiratory rate and a higher ratio of forced expiratory volume in 1 second/forced vital capacity than the controls (P <0.05). More patients than controls were observed to have a decreased DLCO below the lower limit of normal (18 of 45 [40.0%] vs 6 of 36, respectively; P=0.041). Among the 48 patients, 8 (16.7%) had abnormal HRCT findings and 27 (56.3%) had abnormal PFT results. Thirty-one (64.6%) patients had lung involvement. Logistic regression revealed that increases in the erythrocyte sedimentation rate (ESR) and CD4/CD8 ratio were associated with lung involvement (odds ratio (OR): 1.037; 95% CI: 1.003–1.072; OR: 9.875; 95% CI: 1.296–75.243, respectively).Conclusions: Pediatric patients with treatment-naive, newly diagnosed rheumatic diseases are prone to pulmonary involvement. Increased ESR and CD4/CD8 are associated with lung involvement in patients. We recommend routine pulmonary evaluation in such patients, especially in high-risk patients, even in the absence of respiratory symptoms, once they are diagnosed with rheumatic disease.
NCOA4 is associated with cancer stem cell markers and acts as a prognostic biomarker for immune infiltration- related lung adenocarcinoma patients
Authors: Luo Lianxiang , Li Manshan
Published: May 2022

Lung adenocarcinoma is a cancer with a high mortality rate and a low survival rate. Ferroptosis can play an important role in anti-tumor immunity and tumor suppression. NCOA4, as a selective cargo receptor for ferritin autophagy turnover, is very important for Ferroptosis. However, NCOA4 used as a biomarker for the diagnosis, prognosis and treatment of lung adenocarcinoma remains unclean. Therefore, we use ONCOMINE, Tumor Immune Estimation Resource, UALCAN, GEPIA, TNMplot, Human Protein Atlas, Kaplan-Meier plotter, OncoLnc, GeneMANIA, STRING, LinkedOmics database to determine the relationship between NCOA4 expression, prognosis and immunoprecipitation in lung adenocarcinoma. Finally, we used OCLR to calculate mRNA expression-based stemness index of LUAD patient’s data in TCGA and analyzed the correlation between NCOA4 and markers of lung cancer stem cells. We obtained the low expression of NCOA4 in lung adenocarcinoma. Moreover, low expression of NCOA4 is positively correlated with poor overall lifetime. Studies based on the TIMER database show that NCOA4 has significant positive correlations with a variety of tumor immune cells, in particular CD8 + T cells, macrophages cells, neutrophil cells, and dendritic cells. Furthermore, we used the LinkedOmics database to evaluate gene co-expression of NCOA4 in LUAD and to investigate their role in tumor immunity and ferroptosis. And we found that NCOA4 is closely related to surface markers of lung cancer stem cells. Therefore, NCOA4 may be a biomarker for predicting the survival and diagnosis of LUAD.
Identification of significant molecules and biological processes in fluoxetine treated lung cancer cells
Authors: Zhang Tingting , Zhao Guofang , Chang Tingxiang , Wang Mengshan , Chung Andrew , Zhang Donghong
Published: May 2022

Fluoxetine has shown anti-cancer responses in non-small cell lung cancer in vitro. However, the anticancer effect and mechanism of fluoxetine still need to be elucidated. In this study, we aim to figure out the significant molecules and biological processes by analyzing the RNA-seq data from the GEO database. The GSE200209 was created by the Illumina HiSeq 4000 (Homo sapiens). By analyzing the KEGG and GO enrichments, we found that the Lysosome and Autophagy are the major signaling pathways in the fluoxetine treated lung cancer cells. We further identified the top ten interactive molecules including CDK1, CCNB1, MAD2L1, AURKB, MCM3, MCM, CDC45, CDC20, RFC4, and CCNB2. This study may guide the treatment of lung cancer by using fluoxetine.
Vegans, vegetarians and omnivore diets differ in nutrient hedonics, flavouring and salt and sweet taste.
Authors: micah  , Shaul Smadar
Published: May 2022

PurposeDietary content can influence taste responses. Therefore, we compared nutrient hedonics (liking foodsby nutrient content), and seasoning, including taste responses to the prime flavours salt and sweet in vegans (16 men 14 women), vegetarians (38, 24) and omnivores (55, 38).MethodsQuestionnaires and taste tests examined macronutrient and electrolyte intake and hedonics, seasoning, salt and sweet preferences and psychophysical taste responses.ResultsCompared to omnivores, vegans had lower protein, Ca++, Na+ intake, and increased CHO intake. Independently of intake, hedonics for protein Ca++ and Na+ were reduced and increased for CHO. Psychophysical responses to NaCl and sucrose also differed slightly, vegans and vegetarians scoring high concentrations of sucrose as more intense, Vegans reported more sweetening and less salting of food, added more sucrose to a test tea, less salt to a test soup, but did not differ in seasoning with oil or hot spice.ConclusionHabitual vegan, vegetarian and omnivore diets may alter taste responses to nutrient content and salt and sweet, the latter more pronounced in vegan and vegetarian women. Recognising diet-dependent changes in taste hedonics can inform diets and products.
Water Blooms—A potential threat to male reproduction: Clues from fishes and rodents
Authors: Liu Shengdi , Li Hua
Published: May 2022

Toxic cyanobacteria blooms are a potential threat to global aquatic ecosystems and human health. Microcystin-leucine-arginine (MC-LR) is the most toxic variant of microcystins (MCs), and exposure to MCs can damage the male reproductive system. Two electronic databases were searched for controlled studies of rodents and fishes published before September 2020. Effect sizes were calculated for eight main reproductive parameters, including sperm count, sperm motility, sperm morphology, serum testosterone, testis weight, serum follicle stimulating hormone (FSH), serum luteinising hormone (LH) and serum estradiol. Nine meta-analyses of individual parameters were conducted using R version 4.0.2. Fifteen studies were included in the meta-analysis. In the studies of rodents, exposure to MC-LR by intraperitoneal injection or intragastric administration yielded statistically significant effects on sperm count (standardised mean difference (SMD) = -1.7426 (95% CI: -2.2098 to -1.2754)), abnormal sperm rate (SMD = 1.6714 (95% CI: 0.9702 to 2.3726)), sper5% CI: -3.9811 to -1.7834)), testis weight (SMD = -2.8822 (95% CI: -3.9811 to -1.7834)) and serum FSH (SMD = 0.4707 (95% CI: 0.0659 to 0.8756) changes in serum testosterone (SMD = 0.5521 (95% CI: 0.1652; 0.9391)) and estradiol (SMD = 0.6398 (95% CI: 0.1896 to 1.0900)) concentrations are considered to be statistically significant. Dose–response analysis reflected the dynamic changes of male reproductive function caused by MC.Short-term exposure to MC-LR can affect the function of the male reproductive system in rodents and fish. Elevated dosage or extended exposure time may worsen the damage. Human-related research on MC-LR exposure is very necessary to protect health and the water environment.
Mesenchymal stem cells protect against sepsis-associated acute kidney injury by inducing Gal-9/Tim-3 to remodel immune homeostasis
Authors: Luo Congjuan , Luo Feng , Che Lin , Zhao Long , Zhang Hui , Man Xiaofei , Bu Quandong , Zhou Haiyan , Xu Yan
Published: May 2022

Objective: The aim of the present study was to investigate the specific mechanism by which MSCs protect against SA-AKI. Methods: Male C57BL/6 mice underwent cecal ligation and puncture operation to induce sepsis and then received either normal IgG or MSCs (1* 10 6 cells intravenously) plus Gal-9 or soluble-Tim-3 3h after surgery. Results: After cecal ligation and puncture operation, injection with Gal-9 or MSCs plus Gal-9 had a higher survival rate than the IgG treatment group. Treatment with MSCs plus Gal-9 decreased serum creatinine and blood urea nitrogen levels and improved recovery of tubular function. Reduce the levels of IL-17, RORγt and induce the expression of IL-10 and FOXP3. Additionly, remodel the balance of TH17/Treg. However, when used soluble Tim-3 to block the Gal-9/Tim-3 pathway, the septic mice developed badly kidney injury and exhibited a higher mortality. Treatment with MSCs plus soluble Tim-3 blunted the therapeutic effect of MSCs, and inhibited the induction of Tregs and suppressed the inhibition of the differentiation to Th17 cells. Conclusion: Treatment with MSCs significantly reversed the TH1/TH2 balance. And the important mechanism for MSCs protection against SA-AKI maybe through the Gal-9/Tim-3 pathway.
The influence of shunting left/right portal vein branch on post-TIPS hepatic encephalopathy: a study protocol for multicenter randomized single-blinded controlled trial.
Authors: Ma Jingqin , Luo Jianjun , Zhang Wen , Yan Zhiping , Zhou Yongjie , Zhang Zihan , Yang Minjie , Zhuang Zhiquan , Ma Li , Yu Jiaze , Zhou Xin
Published: May 2022

Introduction: Gastroesophageal varices (GOV) bleeding is a common and serious complication of advanced liver cirrhosis with median survival of less than two years. Multiple guidelines have pointed out that transjugular intrahepatic portosystemic shunt (TIPS) is the rescue treatment of acute variceal hemorrhage (AVB) after failure of standard therapy, and an effective second line treatment for preventing patients with high risks from rebleeding of GOV. The safety and stability of TIPS have been greatly improved due to the improvements of related technologies and the emergence of various novel devices, but the incidence of hepatic encephalopathy (HE) after shunting (10-50%) hindered the widespread use of TIPS. The target portal vein branch might affect the incidence of HE after TIPS. The aim of this study is to compare the rate of HE in patients with hepatitis B virus (HBV) related cirrhosis receiving TIPS either left or right branch of portal vein with 8mm Viatorr stent for preventing rebleeding from GOV.Methods and analysis: This study is a multicenter randomized controlled trial comparing the influence of shunting left or right portal vein branch on post-TIPS hepatic encephalopathy for preventing rebleeding from GOV in patients with HBV related cirrhosis. A total of 130 patients will be recruited over a period of 24 months across 5 centers in China. Eligible patients will be stratified 1:1 to constructing either left or right portal vein shunt with 8mm Viatorr stent. The primary objective was to compare the incidence of post-TIPS hepatic encephalopathy between the two groups. The secondary objectives were to compare the grade and duration of hepatic encephalopathy, the rate of shunt dysfunction, the rate of variceal rebleeding, the HE free survival, the cumulative patency rate of stent and the overall survival at 12 months and 24 months between two groups.Ethics and dissemination: This study was approved by the ethics committee of Zhongshan hospital of Fudan University (No. B2018-292R) and was registered at ClinicalTrials.gov (NCT03825848). All participants give written informed consent. Trial registration: This study was registered at ClinicalTrials.gov on January 31, 2019. The registration number is NCT03825848.Trial status: The first patient was recruited into our study on June 19, 2019. A total of 55 patients were recruited till May 27, 2021 (27 and 28 patients assigned to shunting left (L Group) and right (R Group) branch of portal vein, respectively).
Organization of labor processes in an unstable global ecosystem
Authors: Smaliichuk Hanna , Vasylyk Alla , Vonberh Tetyana , Bilyk Olga
Published: May 2022

The pandemic has adjusted employment processes and accelerated the destabilization of the latter, forcing countries to step up the use of digital economy opportunities to support business activity during forced job cuts and pandemic restrictions. The aim of the article is to develop post-pandemic recommendations and scenarios for the organization of labor processes in the direction of strengthening the effective operation of companies in possible crises. The key reasons for the instability of modern labor processes are analyzed, the main world practices of legislative consolidation of telework, which are aimed at reducing the impact of the COVID-19 pandemic on business processes and labor relations, are studied. The need for changes in the organization of modern labor processes and the development of regulations for the organization of labor activity in the new socio-economic conditions is emphasized. The main components of labor process regulations are identified: state policy and regulatory regulation (the degree of readiness to return to normal work and its evaluation at the national and regional levels), personnel component (occupational health, safe working conditions, planning and regulation of production activities), operational component (business processes and benchmarks, cybersecurity and data confidentiality), commercial component (protocols of interaction of participants in production processes, integration of employees on security issues).
Programa Minha Casa Minha Vida: Avaliação pós-ocupação do Residencial Esplendore em Ponta Grossa – PR
Authors: Pacheco Juliana Thaisa Rodrigues , Kawanishi Juliana Yuri , Scheffer Sandra Maria
Published: May 2022

O Programa Minha Casa Minha Vida, lançado pelo governo federal em 2009, possibilitou o acesso à moradia formal a uma parcela da população que, muitas vezes, era excluída do sistema mercadológico. Desta forma, destaca-se a importância de avaliar a criação do Programa com o intuito de compreender a sua eficácia, eficiência e efetividade no que diz respeito ao acesso à cidade pelos mutuários. A avaliação pós-ocupação apresenta-se como instrumento para a compreensão da eficácia e efetividade do Programa, uma vez que considera seus elementos objetivos e subjetivos,como a satisfação dos beneficiários. Neste contexto, o presente artigo visa a identificar as características apresentadas pelas famílias mutuárias pelo Programa Minha Casa Minha Vida, em Ponta Grossa-PR, no que se refere à efetividade do direito à cidade, tendo por base a avaliação pós-ocupação no Residencial Esplendore. Os dados apresentadosforam extraídos do relatório pós-ocupação, de 2015 a 2016. Procurou-se analisar e compreender as demandas apresentadas pelas famílias e as lacunas deixadas pela política habitacional brasileira em setores como o transporte coletivo. Os dados analisados apresentam as dificuldades enfrentadas pelos beneficiários no período pós-ocupação,tais como no transporte público, distância e na falta de acesso aos equipamentos públicos, elementos que interferem no acesso ao direito à cidade.
Entre o Carvão e a Transição Energética: Oscilações na Política de Desenvolvimento do Rio Grande do Sul
Authors: Brose Markus Erwin
Published: May 2022

O governo do Estado do Rio Grande do Sul decidiu recentemente pelo fomento à gaseificação de carvão mineral. Essa decisão rompeu tanto com a tradição do diálogo com os Conselhos Regionais de Desenvolvimento sobre o investimento estatal quanto com a prioridade à energia de fontes renováveis. O objetivo deste texto consiste emanalisar o contexto, os atores e o discurso dessa decisão estratégica tomada em nome do desenvolvimento territorial. O escrito utiliza o Enfoque Multinível proposto por Frank Geels para argumentar que esse retrocesso ao carvãomineral decorre de incentivos existentes na economia global, no nível macro, pela política de combate à crise do carvão mineral na China, contrariando o pioneirismo gaúcho ao nível micro, com nichos de inovação em energia eólica e fotovoltaica enraizados no território, bem como decisão, pelo governo federal, ao nível meso, de encerrar os subsídios para termelétricas a carvão. Entre os resultados registra como falso o argumento a favor da eficiência de mercado na cadeia produtiva do carvão gaúcho, pois planejadores, financiadores, produtores e consumidores são empresas estatais. Registra, igualmente, como falso, o discurso por servidores públicos, consultores e técnicos da iniciativa privada acerca do “carvão sustentável” no RS.
Dynamics of weight loss of dolomite dropouts at different stages of dissolution in Albic Retisol
Authors: Litvinovich Andrey , Pavlova Olga , Lavrishchev Anton , Bure Vladimir , Saljnikov Elmira
Published: May 2022

In a laboratory experiment in 2020, the dynamics of the decrease in mass of large particles of dolomite dropouts in acidic Albic Retisol was established. Dolomite dropouts were collected from the landfill of a road construction factory. The results of the laboratory experiment showed that after 114 days of composting, the loss of dolomite mass ranged from 8.7 to 34.2 % of its initial content. The loss of mass of particles during composting from 114 to 224 days slowed down and fluctuated, depending on the variant, from 2.2 to 5.1 % of the initial mass of dolomite. The mechanism of weathering was considered and the factors enhancing the rate of dissolution of dolomite dropouts in the soil were revealed. Linear empirical dependencies of the rate of dissolution of dolomite in soil at different stages of the experiment were developed. Clustering of the developed models was carried out according to the absolute values ​​of the rate of decrease in the mass of particles in the vessels. When selecting the dose of application of large particles of dolomite for reclamation of acidic soils and duration of their action, it is recommended to take into account the duration of time the dolomite spent in the landfill.
Bird summer distribution patterns on islands in Onega Bay, White Sea
Authors: Simonov Sergey , Matantseva Maria
Published: May 2022

We studied avian populations and distribution patterns on 20 islands in Onega Bay, White Sea, with transect surveys completed to register selected biotic and abiotic factors in July 2020. Bird population densities proved to be the highest on small secluded islands rarely visited by humans and on treeless islands. We also found positive correlations between the species richness and the island size, presence of woody vegetation, and human visitation. It is noteworthy that although human interference can cause species diversity on the islands to increase, the relative abundance of birds declined. Furthermore, species diversity increased due to the arrival of species atypical of this region and, hence, lacking the complete set of requisite adaptations. Further human pressure on the islands can eventually destabilise their avifaunal complexes and aggravate the current transformation of northern communities in response to climate change.
Olfactory lateralization in non-human mammals: a mini-review
Authors: Berezina Ekaterina , Giljov Andrey , Karenina Karina
Published: May 2022

The asymmetric use of nostrils and few contralateral projections in olfactory neural pathways allow us to suppose the dominance of one hemisphere in the processing of various odours in non-human mammals. Although olfaction is the most important sensory domain for many mammals, lateralization of this sense is poorly studied in this group of animals, and the existing limited knowledge is based on experiments on laboratory and domestic mammals. Here we review the most important studies in this developing field, with an emphasis on the methods used. Most of the recent studies indicate the dominance of the right hemisphere in the processing of social and aversive odours and analysis of familiarity of the olfactory stimuli. Dominance of the left hemisphere was found only in a form of a slight trend in the perception of food odour. Almost all existing results on olfactory lateralization are in line with the well-studied patterns of visual lateralization. However, further focused investigations are needed to confirm this consistency. Studies on a wider range of species and stimuli will help to get a better understanding of the relative hemispheric roles in olfactory perception.
Venetian Cinquecento Pictures and France in the 1820s: Painting, Perception, Influence
Authors:   University of Bari Aldo Moro, Sedleryonok Valeria D.
Published: May 2022

This article deals with reassessing Venetian Cinquecento painting in France in the 1820s. This research is a series of case studies related to this problem and providing various types of historical analysis. It examines particular artworks, artistic, social, political contexts, and the influence of Venetian art on the formation of a new artistic language in France in the 1820s. Using an analysis of a wide range of both visual and verbal primary sources, I explore theoretical and practical aspects of the reassessment of Venetian Cinquecento painting in early nineteenth-century France. The paper presents a detailed examination of various French publications of that time regarding Venetian art, as well as a comparative analysis of artworks by Venetian and French artists, namely, Jacopo Robusti, Paolo Veronese, Andrea Schiavone, Eugène Delacroix, Xavier Sigalon, and Eugène Devéria. In this article, I address the following questions. What was the knowledge about Italian Renaissance art in France in the early 19th century? What place did the Venetian school take among the Italian schools of painting in the French consciousness at that time? How was Venetian painting perceived, revisited and presented? How did it influence the formation of a new artistic language in the 1820s? This study reveals the causes, specifics, aspects, and far-reaching consequences of the reconsideration of Venetian Cinquecento painting in the 1820s and its significance for the understanding of the patterns of art development in 19th-century France.
Representação descritiva de documentos musicográficos
Authors: Sousa Ana Claudia Medeiros de , Reis Dayane Patrícia Silva dos , Santos Gleice Pereira dos
Published: May 2022

Esta pesquisa buscou analisar os atributos de descrição bibliográfica e de autoridade de documentos musicográficos, a partir do Código de Catalogação Anglo-Americano (AACR2) e da Resource Description Access (RDA). A partitura escolhida foi a de autoria de Chiquinha Gonzaga, intitulada ‘Ó abre alas’. Para tanto, a pesquisa se caracteriza como descritiva e documental. Na análise dos dados foi adotada a abordagem qualitativa, com o intuito de interpretar os aspectos inerentes às partituras e aos elementos de descrição. Os resultados apontaram que o processo de representação bibliográfica e de autoridade, tendo como base os códigos, normas e formatos, possibilitam que os documentos musicográficos sejam passíveis de descrição e, sobretudo, de recuperação. Observou-se que os atributos e atualizações sugeridos pela RDA, tais como o acréscimo do campo de descrição para tipo de conteúdo; os atributos relacionados à pessoa que incluem: campo de atividade, ocupação, dados biográficos, informações sobre a família, local associado, etc., são informações que contribuem para compreensão dos usuários do contexto em que o documento foi produzido, que no caso de partituras, essas informações colaboram na preparação da performance do músico que irá realizá-la o mais próximo possível da ideia do compositor.
Práticas informacionais de pessoas surdas
Authors: Santos Sylvana Karla da Silva de Lemos
Published: May 2022

Trata-se de uma investigação com o intuito de descrever as práticas informacionais de usuários Surdos por meio da web e as dificuldades enfrentadas por eles, considerando principalmente a barreira linguística. A pesquisa pondera que o sujeito Surdo é aquele que se comunica por meio da Língua Brasileira de Sinais – Libras, como primeira língua e utiliza a língua portuguesa no formato escrito como segunda língua. A metodologia tem caráter descritivo com abordagem qualitativa e contou com a participação quatro indivíduos Surdos e usuários da Libras. A coleta dos dados utilizou um instrumento de coleta elaborado em duas versões: língua portuguesa e Libras. A partir dos resultados, percebe-se que os Surdos estão tendo mais oportunidades no contexto acadêmico e no mercado de trabalho, mediante legislações que buscam incluí-los e minimizar as dificuldades de acessibilidade. A análise dos dados permitiu que fossem lançadas algumas considerações quanto às práticas informacionais desse grupo, considerado minoria, em uma sociedade tão diversa.
Tuberculosis: Current Progress in Drug Targets, Potential Drugs and
Therapeutic Impact
Authors: Masand Mukesh , Kumar Sharma Pramod , M. Balaramnavar Vishal , Mathpal Deepti
Published: May 2022

The World Health Organization (WHO) considers tuberculosis to be the most dangerous chronic communicable disease in the world, infecting two billion people or one-third of the world’s population. Tuberculosis (TB) caused by Mycobacterium tuberculosis remains a leading cause of mortality worldwide into the 21st century. Tuberculosis is second only to AIDS among other infectious diseases in causing deaths worldwide. The emergence of AIDS, multidrug-resistant TB (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB), the decline of socioeconomic standards, and a reduced emphasis on tuberculosis control programmers contribute to the disease’s resurgence in industrialized countries.
Comparative Analysis of Anti-corruption Reporting by Daily Trust and the Nation Newspapers in the First and Second Tenure of Nigeria’s Muhammadu Buhari Government
Authors: Aliagan Isiaka , Yahaya Abdulkadir , Babatunde Kamaldin
Published: May 2022

Studies on corruption coverage by newspapers in Nigeria during the Buhari administration focused on broad corruption issues, his first tenure, and almost zero studies on anti-corruption during his ongoing second tenure to lapse in 2023. This study aims to examine anti-corruption reporting by two Nigerian newspapers, Daily Trust and The Nation, within the first and second tenures of the Buhari administration. The study content-analyzed 475 editorial contents covering the first year in each of the first and second tenures (2015/2016 and 2019/2020). Findings revealed that The Nation reported more stories on anti-corruption than the Daily Trust in both the first and second tenures. However, both newspapers recorded a significant drop in corruption coverage in the second tenure. News stories took the lead in the first and second tenures, with 72.4% and 84.4%, respectively. The study found that both newspapers published more front and back page contents in the first tenure than in the second tenure, but published less front and back page reports on corruption compared to reports on the inside pages during the period of study. The newspapers also published more stories, measuring more than 100 lines during the second tenure than the first. In contrast, more uncritical reports of anti-corruption were published in the first tenure than in the second by the two. The study concluded that poor investigative journalism drive, among other factors, was responsible for the decline in corruption reports, especially during the 2019/2020 period. It recommends that newspapers strive not to allow ethno-religious interests to influence editorial responses on corruption and increase their investigative journalism drive to win the corruption war in the country.
Physical Activity and Nutrition Intervention for Middle Schoolers (Move More, Get More): Protocol for a Quasi-Experimental Study
Authors: Grimes Amanda , Lightner Joseph S , Eighmy Katlyn , Wray Bridget D , Valleroy Ella , Baughn Maya
Published: May 2022

Background

Physical activity and nutrition behaviors are important to reducing the prevalence of childhood obesity. Previous research has identified school-based interventions as effective strategies to improve physical activity and nutrition. However, the results are often mixed, and middle schoolers are an under-studied population.

Objective

Our study aims to fill this gap by developing an after-school intervention to increase physical activity and fruit and vegetable consumption that is influenced by national guidelines and formative research.

Methods

This study was an after-school, quasi-experimental study spanning 9 months. Enrollment began in September 2021 and continued on a rolling basis through February 2022. Weekly, middle schoolers were offered 2-3 physical activity sessions and 1 produce kit. Physical activity was measured using accelerometers and questionnaires. Nutrition behaviors were assessed using questionnaires, and physical literacy was assessed using researcher observations. Follow-up data collection occurred in December 2021 and in April 2022. Difference scores will be calculated and analyzed for each outcome variable.

Results

The intervention started in September 2021 and will conclude in May 2022. Published study results are expected in late 2022.

Conclusions

An increase in physical literacy, physical activity, and fruit and vegetable consumption is expected. If successful, future studies will focus on reach and sustainability. Lastly, this study may serve as a model for improving health outcomes in middle schools.

International Registered Report Identifier (IRRID)

DERR1-10.2196/37126
The Influence of Problem Solving, Self-Management and Technology Development on Entrepreneurship with Intervening Variables of Teamwork
Authors: Zen Agustian , Malik Aulia Januar
Published: May 2022

The purpose of this study was to determine the influence of problem solving, self-management, and technology development on entrepreneurship with the intervening variable of teamwork. This study uses a quantitative analysis method (quantitative), namely research using the output of the statistical analysis process on primary data, which is the answer or feedback from respondents who collected through a questionnaire (questionair). This research was conducted at Bhayangkara University, Greater Jakarta, Bekasi. The number of samples set as many as 99 respondents using purposive sampling method. The data processing technique uses PLS 3.0 tools. Based on the results of the tests that have been carried out, it shows that the indicators are valid and reliable. Problem solving to teamwork has a positive effect of 9.354, self-management to entrepreneurship has a negative effect of 0.606, technology development to entrepreneurship has a positive effect of 4,005 and teamwork to entrepreneurship has a positive effect of 9.354.