bluuebunny/crossref_metadata_2025 huggingface dataset:
RESTRUCTURING THE SECOND MODULE IN DISCIPLINE “PATHOPHYSIOLOGY” IN VIEW OF WARTIME CHALLENGES
Authors: Akimov O.Ye. , Mischenko A.V. , Solovyova N.V. , Zakolodna О.E. , Kostenko V.O.
Published: March 2023

The Ukrainian educational system is facing new challenges during wartime. To meet these new demands, the Department of Pathophysiology at Poltava State Medical University has revised the Master's Degree in Medicine curriculum, taking into account the specificities of providing healthcare during martial law. The goal of this initiative is to develop and substantiate an updated structure for Module No. 2, "Pathophysiology of Organs and Systems". The authors have given particular attention to the revision of the morbidity structure in military forces, which has changed significantly during hostilities. The consequences of blood loss and post-hemotransfusion reactions are prevalent, thus the possibility of allocating additional hours for practical sessions and lectures to study the pathogenetic influence of blood loss and the mechanisms of post-hemotransfusion reactions were considered. Furthermore, due to the possible damage inflicted on the civilian population by combat poisonous substances, a methodological approach has been added to the teaching of the theme on hypoxia. To address the challenges of wartime, Module No. 2, "Pathophysiology of Organs and Systems" will be expanded with two practical sessions ("Mechanisms of the Pathogenic Effect of Blood Loss on Organs and Systems", "Pathogenetic Methods of Blood Loss Correction and their Complications") and one lecture session ("Blood Loss: Aetiology and Pathogenesis") by redistributing hours from independent work. When teaching the topic "Hypoxia", special attention should be paid to the mechanisms of methemoglobin formation by various methemoglobin producers and the mechanisms of restoring hemoglobin to the physiological state by means of hyperbaric oxygenation, as well as the pathogenesis of tissue hypoxia under the action of hydrocyanic acid.
CURRENT PROFESSIONAL AND PEDAGOGICAL REQUIREMENTS FOR EDUCATORS OF HIGHER MEDICAL EDUCATIONAL INSTITUTION
Authors: Nіemtchenko І.І. , Liakhovskyi V.І. , Lysenko R.B. , Liulka O.N. , Krasnov O. G. , Ryabushko R.M. , Horodova-Andryeyeva T.V.
Published: March 2023

The primary role of educators at a higher medical educational institution involves sharing knowledge, providing educational guidance, and ensuring students understand the subjects they teach. This mission requires special mental traits, long-life training, ability to combine the knowledge and erudition of a scientist and the art of a teacher, high intellectual and moral maturity, awareness of the duty and responsibility for fostering and training highly qualified medical specialists.

Therefore, the professional pedagogical activity of educators must be considered as a complete dynamic system that combines the theoretical components related to providing the essence of science and practical components aimed at solving specific practical tasks.

The article considers the modern requirements for educators of a higher medical educational institution, determines the complex of the personal, professional and pedagogical characteristics. The main functions of the pedagogical activity of a modern educator of a higher medical educational institution over the course of doctor’s training are supported by various innovative teaching and learning technologies aimed at strengthening the motivation to study, ability to work independently, fostering clinical thinking, professional skills and abilities. This enables to achieve new results in the formation of the student's personal qualities, creating a basis for the further development of a creative personality, their preparation for future independent medical activity as well as the awareness of the need for lifelong education.
EMOTIONAL INTELLIGENCE AND MANIPULATIONS IN THE EDUCATIONAL PROCESS
Authors: Fedorchenko V. I. , Polianska V.P. , Zvyagolska I.M. , Derevіanko T.V. , Bobrova N. О.
Published: March 2023

Introduction. A teacher at a higher education institution should be well aware of the achievements in psychology to create a harmonious atmosphere when working with students. Purpose. One of the general competencies provided by the curriculum of the discipline "Microbiology, Virology, and Immunology" is the choice of interaction strategy. Choosing a communication strategy is the subject of this article. Possessing knowledge and skills to build up a constructive communication between people is an important component of the learning process and realization in the chosen career and personal life. Discussion. The Department of Microbiology, Virology, and Immunology at the Poltava State Medical University pays considerable attention to the constant improvement of teaching methods at the medical, dental, and international faculties, using both Ukrainian and English as languages of instruction. Competent interaction between participants of the educational process is an integral part of forming the ability of medical students to choose constructive communication strategies further in their profession. The article considers such concepts as "Emotional intelligence", "Humanistic goals of training a future doctor", and "Manipulations". The teacher's awareness of these concepts is important for the perception of his work's psychological aspects. Itwill contribute to teaching effectiveness and decrease professional burnout. Knowledge and practical skills acquired by a student in social interaction during training are significant in the professional activity of the future doctor. The effectiveness of his activity largely depends on his communication skills. These skills relate to the nature of each doctor's relationship with patients, subordinates, colleagues, and managers of a medical institution. Conclusions. 1. Today we are facign the growing importance of the teacher's awareness of the achievements of modern psychology. 2. The teacher should choose relevant strategies for fruitful interaction with students to improve learning outcomes. 3. Competent construction of interaction between all parties of the educational process is an important component in forming the ability of future doctors to choose constructive communication strategies in their professional activities.
ORGANIZATION OF MEDICAL SUPPORT OF MILITARY UNITS DURING COMBAT OPERATIONS ON THE BASIS OF THE PRINCIPLE OF "GOLDEN HOUR"
Authors: Mohylnyk A. , Tarasenko K. , Adamchuk N. , Sonnik Ye. , Arkhipovets O.
Published: March 2023

Against the background of the military invasion of Ukraine by the Russian Federation, various aspects of the problem of improving the provision of medical assistance to the military personnel during combat operations in the near future after receiving injury. The characteristic feature of the death rates in armed conflicts of the past decades is the increase in the number of deaths in the first hour after receiving a combat injury. Current trends in optimization of the provision of assistance to the wounded in all types of combat impressions are based on timely diagnosis and elimination of life-threatening consequences of penetrating and fire injuries, starting from the place of their receipt. The level and effectiveness of medical support for military units in emergency situations of military time depend on the progress and results of the fighting injury in the wounded. The possibility of preventing potentially fatal consequences of the injuries is realized by elimination of life threatening conditions as soon as possible after their receipt on the battlefield. At the same time, the implementation of measures aimed at the interruption of the mechanism of tanatogenesis should start from the pre-stage and continue during the whole process of evacuation of the wounded. The key importance in these conditions is the knowledge of the main modern tendencies of construction of medical and evacuation schemes, the main goal of which is to reduce the terms of providing qualified surgical and resuscitation assistance. The purpose of the work is to form on the basis of analysis of modern literature sources of information mass data on the role of the principle of "golden hour" in the organization of medical support of military units during combat actions. The article provides theoretical substantiation of the importance of the factor of time in elimination of consequences of combat wounds and revealed the basis of the principle of "golden hour" in providing medical care to the wounded, and also an estimation of the current state of their application in practice of modern combat medicine of the world. On the basis of data monitoring, current trends in the construction of medical and evacuation systems for the care of wounded and injured in the war initiated by the Russians against Ukraine are determined.
SPECIFICITIES OF TREATMENT OF PATIENTS WITH CARDIOVASCULAR RISK IN COMORBIDITY
Authors: Ovcharenko L. , Tsyganenko I. , Rustamian S. , Mokhnachew O. , Zaiats Yu.
Published: March 2023

Recently, much attention has been paid to the concept introduced to the scientific community by the prominent American epidemiologist Alvan R. Feinstein - "comorbidity" (Latin co - together, morbus - disease). In his understanding, comorbidity demonstrates the combination of two and/or more chronic diseases in one patient, which are interconnected by pathophysiological mechanisms, and simultaneously manifest themselves in one patient, regardless of the degree of activity of each of them. At the same time, comorbidity leads to the formation of new mechanisms of disease development, the unfolding of an additional clinical picture and the addition of complications and courses that are not characteristic of the underlying disease, with a significant negative impact on the quality and duration of life of patiens. Among all patients with comorbidities, patients with cardiovascular risk have been and remain one of the most difficult among all categories of patients. One or other comorbidity can prognostic allylead to a deterioration in the patient's functional state and increase probability of life-threatening risks. Providing proper medical careto patients with comorbidities requires additional economic expenses in the health care system in order to ensure a comprehensive diagnostic procedure and treatment algorithm. To improve the prognosis of patients with comorbidities and reduce the economic burden on the health care system, it is necessary touse a multicomplex approach at the stages of prevention, diagnosis and treatment of major non-communicable diseases that mainly form comorbidity.
NOOTROPICS: A LONG WAY IN HALF A CENTURY
Authors: Sydorenko A.H.
Published: March 2023

Introduction. Currently, there are drugs that can improve cognitive processes. They are nootropics. The term "nootropics" was introduced in 1972, when piracetam's memory-enhancing properties were discovered, and this group of drugs has served the human benefit for half a century. The purpose of the work is to analyze known facts and new trends in the development of nootropics as a pharmacological group. Materials and methods. Internet resources (PubMed, Google Scholar, CrossRef) are used to search for information. Original research articles, meta-analyses and systematic reviews are included in the study. Attention was focused on providing an up-to-date overview of known means. Main part. For classification, the distribution of nootropics according to the mechanism of action is proposed. Nootropics have both a receptor mechanism of action and improve the supply of glucose and oxygen to the brain, the synthesis of proteins, nucleic acids and phospholipids, eliminate oxygen free radicals, have an antiplatelet effect, and optimize cerebral blood circulation. They are used for the treatment of psycho-organic syndrome. Nootropics are effective in providing benign senile disease, in children with minimal brain dysfunction syndrome, in case of encephalopathy and myalgic encephalomyelitis. Nootropics are indicated for patients with Alzheimer's disease, schizophrenia, hyperkinetic disorder. They are well tolerated. Their effectiveness depends on the dose, and after the disappearance of the disorder, the treatment should be continued for at least 2-3 weeks. Nootropics attract the attention of practically healthy individuals, in particular, students, but their use by healthy people is against concern due to the absence of clinical evidence of effectiveness, safety and social consequences. Some of the most famous nootropic drugs are piracetam, pyritinol, nicergoline, and vinpocetine, which have certain shades of pharmacodynamics, dosage, and side effects. Conclusions. Therefore, all nootropics improve cognitive function, especially in cases of the damage or degeneration, are well tolerated and should be prescribed by a specialist in each specific case. New research is needed to confirm or simplify the beneficial effects of nootropics in healthy individuals.
CONGENITAL DISORDER OF GLYCOSYRATION TYPE 1B (CDG-1B SYNDROME, PHOSPHOMANNOISOMERASE DEFICIENCY): A CLINICAL CASE
Authors: Fesenko M. Yе. , Scherban O.A. , Kozakevіch V. K. , Zyuzina L.S. , Kaliuzhka O.O.
Published: March 2023

A clinical case of my own observation of a boy A., aged 1 year and 10 months, with the diagnosis: congenital glycosylation disorder type 1b (CDG 1b syndrome, phosphomannoisomerase deficiency) is presented. The writing of this article is due to the difficulties of diagnosis, which are associated with the multisystemic clinical manifestations in the form of rather non-specific pathological conditions and the lack of information about this rare pathology. Congenital glycosylation defects are a group of genetically determined diseases in which the synthesis or attachment of glycans to glycoproteins and glycolipids is violated, as well as the formation of glycosylphosphatidylinositol. More than 130 congenital defects of glycosylation are known. According to literature data, in case of congenital glycosylation defects in newborns and older children, life-threatening changes in the body are observed, which include disorders on the part of all organs and systems that contribute to disorders of physical and neuropsychological development. Recently, more and more cases of the debut of congenital glycosylation defects have been described immediately after birth in the form of a syndrome of respiratory disorders; intracranial hemorrhages in full-term newborns; long-term dysfunction of the gastrointestinal tract; life-threatening bacterial infections. The absence of clear, specific clinical manifestations of the disease leads to untimely recognition and treatment of the disease in children after birth and contributes to the violation of their development. The child's final diagnosis is determined by the results of a molecular genetic examination: exome sequencing: a heterozygous carrier of the EXTL3, MFSD8 genes takes place here. A conclusion was made about the need for dynamic observation of the boy by a pediatrician and geneticist in order to monitor physical and neuropsychological development.
ANALYSIS OF THE COURSE OF PREGNANCY, CHILDBIRTH AND THE STATUS OF NEWBORNS BORN BY DISPLACED WOMEN
Authors: Kamilova Nigar M. , Gulieva Lamia A.
Published: March 2023

Aim of the study: to analyse the effect of involuntary migration on the course of pregnancy, labour and delivery, and neonatal outcomes in pregnant women in the third generation. Materials and methods. This paper presents an analysis of a prospective study of the course of pregnancy, childbirth, and the condition of new-born infants born by displaced Azerbaijani women. A prospective analysis was made in the course of puberty and the state of reproductive health in 54 refugee women of early reproductive age, who were divided into two groups, aged 18-25 and 26-35 years. Results. A study conducted among third generation women revealed pronounced negative trends in both somatic and reproductive health among refugee women in this group. Their average age ranged from 18 to 35. Most of the patients, 37 (68.5%), were born with a birth weight of less than 3000g. The mean age of parents at the time of girl's birth was 25.4±2.26 years for mothers, 26.9±5.29 years for fathers, i.e., in the immediate post-stress period. The subjects are characterized by menstrual cycle dysfunction (63%-29.5%). Hypermenorrhoea occurs in 46% of the subjects, primary amenorrhoea in 8.2%, and secondary amenorrhoea in 3.3%. There is also a high percentage of inflammatory diseases of the female genital organs (93.4%). A high percentage of somatic pathologies is found in the female patients: iron deficiency anaemia - 77.8%, gastrointestinal diseases - 48.1%, thyroid diseases - 9.3%, urinary diseases - 22.5%, helminthiasis - 16.7%, etc. Sexually transmitted infections were diagnosed in chronic form in 14 patients. The rate of placental insufficiency of grade 1a and 1b was diagnosed in 29%-16%, and delayed foetal development of grade 1 and 2 in 12%-8% respectively. Asphyxia (27%), newborn hypotrophy (7.5%), prematurity (18%) is characteristic of the newborns of this group of patients. Conclusion. Analysis of the results of a comprehensive study of the health of pregnant refugee women has shown that even in the third generation the stress associated with forced migration of the older generation and adverse socio-medical problems are reflected in the formation and functioning of the reproductive age of the younger generation.
DIABETES MELLITUS AND PSYHOEMOCIYNE TENSION IN WARTIME
Authors: Muravlova O.V.
Published: March 2023

Diabetes mellitus is the most prevalent endocrine pathology that is showing an upward trend. The impact of psychoemotional stress on the course of diabetes is significant. Patients with diabetes are up to four times more likely to experience depression and anxiety than those without the condition in normal circumstances. In the wartime, patients with diabetes have concerns about the potential shortage of essential medicines for managing and controlling diabetes and the emotional effect of the situation. This is especially true for patients with chronic diseases, which worsen every moment, exacerbating fears about their own lives. Access to essential medical resources becomes even more challenging for those living with diabetes, making the psychological effects even more catastrophic. The consequences of military conflict have the potential to affect patients' psycho-emotional state severely. The ability of the patient to control their emotions and seek help in time becomes of paramount importance. At the Department of Endocrinology with Children Infectious Diseases at Poltava State Medical University, a questionnaire was conducted to determine the psychological state of patients with diabetes. The study examined 78 respondents with types 1 and 2 DM who were receiving ongoing treatment at the endocrinology inpatient department. The proposed questionnaire included 50 questions adapted from the Misaway multi-profile personal asylum-applicant for J. Taylor (1953). Respondents were asked to quickly answer "yes" or "no" to each question, with each affirmative response receiving one point. The total assessment of overall anxiety consisted of social, social and neurogenic tension. Testing helped to assess individual psychological characteristics of patients with diabetes, providing a basis for a personalized approach to the treatment.
EMOXIPIN: PROSPECTS OF ITS APPLICATION FOR PREVENTING EARLY RADIATION REACTIONS DURING RADIOTHERAPY IN BREAST CANCER PATIENTS
Authors: Pochernjeva V.F. , Vasko L.N. , Dudnyk T.A.
Published: March 2023

According to global statistics, the frequency of local radiation reactions is on average 10% of the total number of patients who receive radiotherapy. The lack of effective measures to prevent their occurrence can lead to the transition of radiation reactions to radiation damage to healthy tissues that which will not only affect the quality of life of patients who have been cured of malignant tumours, sometimes leading to their disability, but also often cause fatal consequences. The authors of this work developed an ointment formulation based on emoxipin, a drug that has a targeted effect on blood vessels. The purpose of the study is to increase the effectiveness of the therapy for patients who are subject to local radiotherapy by using 1% emoxipine ointment. Material and methods. We conducted the observation of 29 patients with breast cancer, who were subject to adjuvant radiation therapy according to the standards of cancer diagnosis and treatments. Results and discussion. Preventive application of 1% emoxipin ointment one hour before the radiation session and in 1 and 2 hours following it prevented the occurrence of early local radiation reaction in 25% of patients compared to 63% of the participants who applied methyluracil ointment. Emoxipin ointment reduces reactive syndrome, vascular reaction and has an analgesic effect. Conclusion. This approach has been proven as effective means to prevent the transition of radiation reactions to radiation damage, it has significant economic efficiency as can exclude further therapeutic treatment of radiation lesions by using expensive drugs and thus, increases the effectiveness of conservative therapy.
TREATMENT TACTICS FOR GENITAL PROLAPSES IN WOMEN WITH ABNORMAL UTERINE BLEEDING AND THYROID GLAND PATHOLOGY
Authors: Safonov R. A. , Alekseieva O. S. , Lazurenko V. V.
Published: March 2023

Introduction. Patients with genital prolapse have various extragenital pathologies, in particular thyroid pathology, which affects the regulation of the menstrual cycle both in the reproductive and perimenopausal periods of a woman's life. Abnormal uterine bleeding caused by hormonal disorders, functional and organic changes in the thyroid gland is reported as a common problem of perimenopausal age. The aim of this study is to optimize the treatment of genital prolapse in women with abnormal uterine bleeding and thyroid pathology. Materials and methods. 49 perimenopausal women with genital prolapse who had thyroid pathology were examined and treated. They were divided into the main group (29 women with abnormal uterine bleeding) and the comparison group of 20 patients with genital prolapse without abnormal uterine bleeding. 20 women without signs of gynaecological and extragenital pathology made up the control group. Results. The presence of significant deviations in the serum content of steroid hormones in women with thyroid dysfunction allows us to confirm the relationship between proliferative processes in the endometrium and the functioning of the thyroid system. The examination revealed a significant relationship between thyroid dysfunction and the cause of abnormal uterine bleeding. Depending on the treatment method, the women of the main group were divided into 2 subgroups: the first subgroup included 19 patients who underwent vaginal extirpation of the uterus and simultaneous correction of genital prolapse with additional sacrospinal fixation of the vaginal stump using a mesh implant fragment. 10 patients were included in the second subgroup, which underwent hysteroresectoscopy due to abnormal uterine bleeding, and surgical treatment of genital prolapse was performed after a certain period of time (after 0.5-3 years, on average after 21-24 months). In the comparison group, planned vaginal extirpation of the uterus was performed. Conclusion. The improvement of the treatment of genital prolapse in women with abnormal uterine bleeding and thyroid pathology consists in combining vaginal removal of the uterus followed by strengthening of the vaginal dome through the use of sacrospinal fixation and/or a mesh implant in order to prevent recurrences and improve the economic indicators of the medical institution and the quality of life of patients.
PROBIOTIC AS ORAL CAVITY COLONIZATION RESISTANCE INCREASING FACTOR
Authors: Loban G.A. , Нancho О.V. , Petrushanko Т.О. , Moshel T.М.
Published: March 2023

Colonization resistance is the body's first line of defense against the invasion of foreign agents. That is why it is so important to support this front by replenishing one's own microbiome with stabilizing representatives contained in probiotics. Generalized periodontitis is one of the common consequences of a violation of the colonization resistance of the oral cavity mucous membrane and the use of probiotics seems to be a promising direction for its complex therapy. The aim of this work was to study the effect of Lacidofil forte probiotic on the colonization resistance of the oral cavity mucous membrane during the complex treatment of chronic generalized periodontitis. According to the goal, generally accepted dental clinical, paraclinical and microbiological studies were conducted in 18 patients with chronic generalized periodontitis aged 45 to 65 years. A screening assessment of the colonization resistance of the oral cavity mucous membrane was carried out. The method is based on counting the number of adhered streptococci in a scraping from the buccal epithelium. The average number of oral streptococci adhered to one buccal epitheliocyte was counted to determine the adhesive number. The adhesive index was expressed as the percentage of buccal epitheliocytes that adhered more than 10 oral streptococci. The index of colonization resistance was determined in points. Periodontal status was objectiveized on the basis of: Schiller-Pysarev test, the gingival index of RMA according to Parma, the bleeding index of the gingival sulcus according to Mülleman. The state of oral hygiene was assessed using the Fedorov-Volodkina index. Microbiological studies included the determination of the number of microorganisms colony-forming units in the patients' periodontal pockets. Our research allowed us to draw the following conclusions. The development of chronic generalized periodontitis is accompanied by a decrease in the oral cavity colonization resistance, the use of Lacidofil forte leads to an increase in the oral cavity colonization resistance, especially significantly on the 10th day of treatment. The use of the probiotic in the treatment of patients with generalized periodontitis helps to reduce the symptoms of gingivitis. After a course of treatment using Lacidofil forte in the contents of periodontal pockets, the total number of microorganisms, the number of anaerobic bacteria, and the number of gram-positive rod-shaped microorganisms increase.
ASSESSMENT OF EFFECTIVENESS IN APPLYING MULTIDISCIPLINARY EXPERIMENTALLY-BASED APPROACH IN CHOOSING THERAPY FOR PATIENTS WITH FUNCTIONAL MAXILLOFACIAL DISORDERS IN COMBINATION WITH PRIMARY DEEP BITE
Authors: Flis P.S. , Holubchenko O.Yu.
Published: March 2023

Introduction. In recent years, the percentage of adults seeking orthodontic care has been increasing. The management of such a group of patients poses a number of challenges the orthodontists have to solve. One of the common problems that arise during the bite correction with fixed orthodontic appliances is debonding. The highest percentage, 43%, of adhesion disruption is observed in patients with a deep overlap. There is also an increase in the number of dental patients presenting with manifestations of the development of functional occlusion disorders caused by reconstructive prosthetic restorations under the existing bite pathology.

Materials and methods. A comparison of electromyography indicators in patients before and after the treatment was carried out. The study included 51 patients aged 18-45 years (average age was 29.6±6.1 years). The selection was made on the basis of inclusion / exclusion criteria. The first group involved 24 patients (9 men, 15 women) with a deep bite, occlusal disorders with unexpressed architecture of the occlusal surface of reconstructive restorations mainly made of composite and polymer materials; the participants presented no pronounced pain symptoms, but presented complaints about the masticatory muscles (discomfort, trismus, contracture of the lateral pterygoid muscle, bruxism, etc.). Patients of this group were characterized by multiple direct restorations and short-length orthopaedic structures. The second group included 27 patients (10 men, 17 women) with a deep bite, occlusal disorders, pronounced architecture of the occlusal surface of reconstructive prosthetic restorations and existing pain manifestations from the masticatory muscles, which appeared after their functional overload. In order to compare the effectiveness of treatment, each of the clinical groups was divided into 2 subgroups, test and control.

Results. The findings obtained demonstrated the normalization of bioelectric activity indicators after the treatment, both in the control group and in the test group (p<0.05). For patients of clinical group 1, the level of the bioelectrical activity after the treatment in the test group was statistically significantly (p=0.0049) lower than in the control group. The same was observed for the patients from 2 clinical groups (p<0.001)

Conclusions. The scheme of the proposed algorithm for the fixation of orthodontic appliances and measures aimed at normalizing the work of masticatory muscles significantly improves the indicators of functional research methods, in particular, the indicators of bioelectric activity during electromyography in patients of all study groups.
EFFECT OF ENTERAL NUTRITION IN COMBINATION WITH L-ARGININE AND GLUTAMIC ACID ON NUTRITIONAL STATUS IN EXPERIMENT
Authors: Kushta A.A. , Melnyk A. V. , Voloshchuk N. I.
Published: March 2023

The aim of the study is to evaluate the scheme of complex therapy based on enteral nutrition and L-arginine, glutamic acid on the indicators of protein, carbohydrate, and lipid metabolism in the blood of rats with experimental wound defects of the skin under conditions of partial food deprivation.

Materials and methods. A biochemical study of blood was carried out in 24 sexually mature male rats, which were partially food deprived for 10 days. On the 10th day, a wound was made and the animals were divided into 4 groups: the 1st group of control animals, which received food according to physiological needs; the 2nd group, which continued to be partially food deprived; and the 3rd group of rats, which after being exposed to dystrophy modelling for 10 days, were given compensatory enteral nutrition; the 4th group, which after the food deprivation, received L-arginine and glutamic acid in a dose of 50 mg/kg in addition to enteral nutrition. Blood sampling was carried out by removing the animals from the experiment on the 28th day. The following biochemical indicators were studied: the content of glucose, total protein, albumins, urea, the level of non-esterified fatty acids (NFA), ketone bodies, ammonia and TBC-reactants.

Results. Comparative analysis of glucose content showed that integrative therapy prevented the development of hypoglycemia under the conditions of partial food derivation (р˂0.05). The positive effect of the combined action of enteral nutrition and L-arginine, glutamic acid on the serum content of total protein was found to be higher by 18% (р˂0.05), and albumin by 39% (р˂0.05), urea and ammonia was by 50% and 40.1% smaller (р˂0.05), NEJK was lower by 32.4% (р˂0.05), the content of ketone bodies was lower by 73.2% (р˂0.05), and TBK- reactants was lower by 50.4% (р˂0.05), compared to the untreated animals, and these indicators did not statistically significantly differ from the control values.

Conclusion. The integrated therapy based on enteral nutrition and L-arginine, glutamic acid under the partial food deprivation effectively normalized protein metabolism, indicators of lipid and nitrogen metabolism in the body of rats (p˂0.05), relative to untreated animals.
Diversity of the Ulidiidae Family (Insecta: Diptera)
Authors: Marchiori Carlos Henrique
Published: March 2023

Ulidiidae makes their nests on the ground, making their eggs and young often very vulnerable to predation. They walk steadily on strong legs and big toes, pecking for food as they go. Many have interesting mating displays, such as inflating throat sacs or raising elaborate feather crests. The female lays three to five dark, speckled eggs in a scratch in the ground and incubates them on her own. In addition to the damage caused by the larvae themselves, their activity facilitates the entry of pathogens into plants, which may cause losses of up to 100% of production. They also carry enteric bacteria, being responsible for the transmission of infections. This mini-review aims to describe the Ulidiidae Family. The methodological basis of the present work consists of bibliographical research of scientific articles published in national and international academic scientific journals classified by the Coordination for the Improvement of Higher Education Personnel. The search criterion for articles was to prioritize articles that dealt with the topic. Document analysis was used as a data collection method to gather information on theoretical books, theses banks, university dissertations, scientific journals, documents, and websites: https://www.researchgate.net/post/How_to_increase_the_research_results_visibility. (https://goo.gl/gLTTTs), HAL (https://hal.archives-ouvertes.fr/submit/index), SSRN (https://hq.ssrn.com/login/pubsigninjoin.cfm) and ResearchGate (https://www.researchgate.net/signup.SignUp.html).
Chronic Urticaria: Seeking the Causes in Iranian Population
Authors:   School of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Azarafraz Mehdi , Hemmatyar Masoumeh ,   Department of Pediatrics, School of Medicine, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran., Abachi Nasim ,   School of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Hashemitari Seyed Karen ,   School of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Darougar Sepideh ,   Department of Pediatrics, School of Medicine, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
Published: March 2023

Background: Chronic urticaria (CU) is the recurrence of erythematous itching papular skin lesions for at least 6 weeks. Although it is often considered a benign condition, there are reports of the association of chronic idiopathic urticaria with infections, thyroid disease, foods, medications, autoimmunity, neoplasms, and low serum level of vitamin D. We aimed to identify the effect of lifestyle characteristics, environmental factors, family history, and specific comorbidities as potential external eliciting factors on the onset of chronic urticaria. Materials and Methods: The present research was conducted on 141 adult patients diagnosed by CU at the allergy clinics of Azad University hospitals in Tehran from January 2021 to January 2022. A questionnaire on different life events during the past 3 months before the onset of urticaria was developed to evaluate the characteristics of the patients with chronic urticaria. Meanwhile, 58 healthy individuals who were similar to the patients in terms of age range and gender were asked to participate in the study as the control group. Results: The mean age of the patients and the controls were 41.7 years and 39.8 years, respectively. The female and male patients were 105(74.47%) and 36(25.53%), respectively. Only two of the evaluated predisposing factors were meaningful including the use of new medications (23.4% versus 19%; P=0.006) and the co-existence of anxiety and depression (14.1% versus 4%; P=0.036). Conclusion: Among the different factors evaluated in this study, only two were found to be significant in relationship with CU which are anxiety/depression and medications.
The Problems and Solutions Regarding RF in Absence of Working Internet
Authors: Jitendra Sunte
Published: March 2023

Now a days entire world has utilizing internet, suppose if we analyze without internet , then we have to go back offline mode every sector whether it may be in banking sector, business commercial or domestic one. It is very critical point to consider life without internet. it is very sad for human beings for luxurious life to utilize technologies unless internet. this paper is dealing with resolution of RF wave stability and its retaining spectrum for absence of internet. Further we can go alternate way to our traditional old techniques based on learning from principles using cameras we can send images shares data ,audio and video. Now the question is how to overcome this problems if such problems arise in future. Off course we don’t know excactly nature rule when and where to happen unknowingly. Avoiding barrier to radio waves is such one way to control attenuation to signals.
A Survey of Numerous Text Similarity Approach
Authors: Joyinee Dasgupta  , Priyanka Kumari Mishra  , Selvakuberan Karuppasamy  , Arpana Dipak Mahajan
Published: March 2023

One of the most common NLP use cases is text similarity. Every domain comes with a variety of use cases. The most common uses of text similarity include finding related articles/news/genres, efficient use of search engines, classification of related issues on any topic, etc. It serves as a framework for many text analytics use cases. Methods to solve text similarity use cases have been around for a while, but the main drawbacks of the old methods are loss of dependency information, difficulty remembering long conversations, exploding gradient problems, etc. Recent advanced deep learning-based models pay attention to both contiguous and distant words, making their learning ability more rigorous. This white paper focuses on various text similarity techniques that can be used in everyday life to solve these use cases.
An Empirical Study of Classification Models Using AUC-ROC Curve for Software Fault Predictions
Authors: Mrs. Prachi Sasankar  , Dr. Gopal Sakarkar
Published: March 2023

Software bug prediction is the process of identifying software modules that are likely to have bugs by using some fundamental project resources before the real testing starts. Due to high cost in correcting the detected bugs, it is advisable to start predicting bugs at the early stage of development instead of at the testing phase. There are many techniques and approaches that can be used to build the prediction models, such as machine learning. We have studied nine different types of datasets and seven types of machine learning techniques have been identified. As for performance measures, both graphical and numerical measures are used to evaluate the performance of models. A few challenges exist when constructing a prediction model. In this study, we have narrowed down to nine different types of datasets and seven types of machine learning techniques have been identified. As for the performance measure, both graphical and numerical measures are used to evaluate the performance of the models. There are a few challenges in constructing the prediction model. Thus, more studies need to be carried out so that a well-formed result is obtained. We also provide a recommendation for future research based on the results we got from this study.
Hybrid Decision Fusion based Multimodal Ensemble Framework for Cervical Cancer Detection
Authors: Lalasa Mukku  , Jyothi Thomas
Published: March 2023

Cervical cancer is fourth in the list of cancers that affect women. It has remained the main cause of death for women in developing nations. The cancer is spread through human papilloma virus (HPV), which is sexually transmitted. Pap smear and colposcopy image analysis remain prominent methods of diagnosis. These screening tests require skilled diagnostic experts, a scarce resource in developing countries thus restricting the effectiveness of the cancer detection process in large scale. Machine learning and deep learning are branches of artificial intelligence that are being used increasingly in cancer diagnosis. This study proposes a novel hybrid intelligent system for cervical cancer detection. A hybrid model of feature extraction and feature fusion is proposed for merging the two-state image and clinical data. Subsequently a machine learning ensemble learner is assembled to classify the features. The model performed with a satisfactory accuracy of 96.16%. Our results show that our method outperforms state of the art approaches and archives better, dependable accuracy.
Effect of Drying Temperature on Physicochemical Characteristics of Tomato Powder
Authors: Amel Selimovic  , Almina Huskic  , Amila Music  , Sabina Merzic  , Halid Junuzovic  , Amra Selimovic
Published: March 2023

Tomato powder is produced by dehydrating tomatoes. The powder consists of only one ingredient, it represents the specificity of this product, namely dehydrated natural tomatoes. Among other things, drying as a preservation process is considered one of the best methods, because it ensures ease of use, transportation and storage. As part of the canning and processing of fruits and especially vegetables, tomato products have always occupied a very important place due to the organoleptic and culinary properties of these products, and the nutritional value of tomatoes as a raw material. Compared to other types of vegetables, tomatoes have a high yield, with some varieties even over 90%.The most important factor in tomato dehydration is the dehydration temperature as well as the time interval during which the dehydration process is carried out. In the dehydration process, two varieties of fresh tomatoes from the local market were used, which were dehydrated at temperatures of 50 and 75 °C. In parallel, a comparative physicochemical analysis of fresh tomato samples with dehydrated ground samples of tomato powder was performed. All analyzes in this research work were edited three times, and the mean value was used to display the graphical results.
Acoustical and Mechanical Characterization of Natural Fibre-Reinforced Composite : A Review
Authors: Indrajit Wadgave  , Dr. Sham Kulkarni  , Dr. Sameer Katekar
Published: March 2023

Noise pollution is increasing in this era as countries' development is faster. This noise pollution causes serious non-auditory effects on human health. As a result, it needs effective controls on noise pollution. Hence, use a natural fibre-reinforced composite for acoustical applications. Natural fibre-reinforced composites have various benefits, such as being eco-friendly, easy to manufacture, and effective in cost, and natural fibre improves the sound absorption, mechanical strength, and structural stability of the composite. The present review describes various techniques for measuring the acoustical and mechanical characteristics of natural fibre-reinforced composites. In addition to these acoustical (sound absorption coefficient, sound transmission losses, etc.) and mechanical (tensile, flexural, impact, etc.) characteristics are reviewed. Furthermore, this review paper studied an influencing parameter that affects the acoustical and mechanical characteristics of natural fibre-reinforced composites. these influencing parameters, such as fibre properties, density, porosity, sample thickness, binder amount, and filler material. In natural fibre-reinforced composites, increasing the percentage of the fibre density, binder amount, and filler material enhances sound absorption and mechanical strength, but these parameters have certain limitations, and crossing the limitation decreases the characteristics. reduce the porosity, decrease sound absorption, and increase sample thickness to increase acoustical characteristics. The conclusion states that the acoustical and mechanical characteristics of natural fibre-reinforced composites are enhanced when considering the performance-influencing parameters.
A Survey on Monitoring and Detecting Cyber Bullying Activities using Machine Learning Algorithms
Authors: Payal Budhe  , Mrs. Dipalee Rane
Published: March 2023

The shrinking of the planet by technology is causing new age difficulties in youth culture. Technology surely has a lot of benefits, but it also has risks. It is where cyberbullying first started. Thus, there are many different types of cyberbullying. It might not necessarily involve pretending to be someone else or breaking into their online accounts. It also includes criticizing someone or spreading lies about them in an effort to cast doubt on them. Social media is widely used, making it incredibly easy for anyone to misuse this access. Cyberbullying is a serious issue today. It includes actions that harass, mislead, or defame someone. These violent behaviors are incredibly hazardous and can harm anyone quickly and severely. They appear on open discussion forums, social media sites, and other internet chat boards. A cyberbully is not always an anonymous person; they could be someone you know. The detection of online cyberbullying has grown in societal significance, research interest, and accessibility of open data. Even so, despite the continued rise in processing power and resource affordability, access limitations to high quality data constrain the use of cutting-edge methodologies. As a result, many recent studies use limited, heterogeneous datasets without fully assessing their usefulness. This study discusses effective techniques used to detect online abusive and bullying messages by merging natural language processing and machine learning algorithms with distinct features to analyze the accuracy levels of the algorithms.
Analysis of Bilateral Trade Between Vietnam and China
Authors: Do Trong Nghia
Published: March 2023

The purpose of this study was to analyze the current status of trade between China and Vietnam. The study used data from the General Statistics Office report to uncover results of import and export activities of Vietnam and China, as well as the disparity between the two countries; aside from that, the study also pointed out the most significant products Vietnam exports to China as well as those Vietnam imports with great value from China. Furthermore, researchers have also found that Vietnam's trade deficit with China is growing, which is one of the major problems when our trade activities are highly dependent on China. Based on that analysis, the study offers several recommendations for enhancing trade between Vietnam and China; in the meantime, this also limits the current trade deficit between Vietnam and China.
The Optical and Structural Properties of CdS Nano particles Prepared By Spray Pyrolysis Technique
Authors: Barzan Kh.Qassim  , Mohammad M. Uonis  , Erada A. Khaleel
Published: March 2023

Thin films of CdS have been prepared on glass substrates by the chemical spray pyrolysis method at 250oC from solutions including different concentrations of Na2S (0.2 g and 0.4 g). The films were examined using SEM, an X-ray spectrometer, and a UV-Visible spectrometer. The SEM images and X-ray spectrum show that the films were amorphous, and the grain size varied with Na2S concentration. The optical properties and optical constants also varied clearly with Na2S concentration; in addition, the energy gap changed from 2.3 eV to 2.4 eV for both films.
Synthesis, Characterization and Biological Activity of Metal Chelates Based On 8-Hydroxyquinoline and 1, 2, 4-Triazol
Authors: Swati Patel  , Dr. Yogesh Patel
Published: March 2023

The present study aims to synthesize a novel ligand namely, 5-((3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl)methyl)-8-Hydroxyquinoline (TFMTHQ) by reacting 5-chloromethyl-8-hydroxyquinoline (CMQ) hydrochloride, a versatile derivative of 8-hydroxyquinoline with 3-trifluoromethyl-1-H-1,2,4-triazole. The co-ordinate metal chelates of the ligand TFMTHQ were prepared using divalent metal ions viz., Cu2+, Co2+, Ni2+, Mn2+, Zn2+ and Cd2+ by a simple method. The ligand TFMTHQ and its all metal chelates were duly characterized for elemental content, spectral features, M: L (metal: ligand) ratio, and magnetic moment. The results of electronic spectral studies and magnetic properties indicated octahedral geometry for all the metal chelates. All the synthesized compounds were tested for antibacterial activity against gram positive and gram negative bacteria. Antifungal activity of all the samples was tested against plant pathogens such as Aspergillus Niger (AN), Botrydepladia Thiobromine (BT), Nigrospora Sp. (NS), and Fusarium Oxyporium (FO). The results showed good antimicrobial activity of all the metal chelates.