bluuebunny/crossref_metadata_2025 huggingface dataset:
Liever geen beeld van Petrus Regout. Bedrijfsjubilea van de Sphinx
Authors: Cillekens Caspar
Published: December 2022

Company anniversaries are excellent opportunities to renew the bond with the workforce and the wider world. They are also occasions for reflections about the company’s past, unwelcome as they may be. In the 20th century, the management of the Maastricht ceramics company De Sphinx had great difficulty setting the stage for its anniversaries. With waves of redundancies etched in people’s memory, the times did not seem ripe in the 1930s and 1980s for high-profile festivities. Interestingly, the initiative for celebrating the company’s 125th anniversary in 1959 was not taken by the management, but by three company foremen. They felt that the Regout family could no longer disregard a celebration. In this article, I shall examine why the company management feared the resurgence of old controversies and was reluctant to celebrate anniversaries. Curiously, the population of Maastricht, often critical of De Sphinx, was also hostage to the past.
IMPLEMENTASI PEMBELAJARAN PAI PADA MASA PANDEMI COVID-19 DI SMP N 1 BUKIT SUNDI TAHUN AJARAN 2020/2021
Authors: Roza Maifadillah
Published: December 2022

During this pandemic, at SMP N 1 Bukit Sundi, students are required to be able to understand and master and apply the material provided by the teacher, one of which is PAI subjects. Therefore, in PAI subjects, inspirational teachers are needed who can improve students' abilities, with conditions where the learning system is not implemented face-to-face. This study aims to find out how to apply PAI learning during the covid-19 pandemic and, what are the obstacles encountered in implementing PAI learning during the Covid-19 pandemic class IX at SMP N 1 Bukit Sundi, Solok Regency. field (field research) with a qualitative approach. From the research that has been done, it can be concluded that the implementation of PAI learning during the covid-19 pandemic at SMP-N 1 Bukit Sundi there were 2 (1) PAI learning during this pandemic was carried out online using WhatsApp Group media and offline learning where students picked up and delivering the tasks given by the teacher once a week to school, (2) the perceived obstacles in learning during the pandemic, which the teacher feels include the lack of facilities and infrastructure to support PAI learning itself, which is felt by students, namely, not all student residences have quality good network, there are also some students who do not have Android phones, and parents of students, namely not all parents are able to provide explanations related to the material that students learn from their teachers, there are also some parents who are busy working so they cannot supervise their children in learning process.
STUDY KOMPARATIF PENGELOLAAN PROGRAM TAHFIZH PADA RUMAH TAHFIZH DI KECAMATAN AMPEK ANGKEK KAB. AGAM
Authors: Nelly Izmi
Published: December 2022

Permasalahan pada penelitian ini dapat dirumuskan sebagai berikut: Bagaimana pelaksanaan program tahfizh antara satu rumah tahfizh dibandingkan dengan rumah tahfizh yang lain di Kecamatan Ampek Angkek Kab. Agam.  Adapun batasan masalahnya adalah: pilihan program Tahfizh, Metode yang digunakan, media yang digunakan, pelaksanaan evaluasi dan problematika yang dihadapi oleh rumah tahfizh.

Metode penelitian adalah penelitian lapangan yang bersifat deskriptif, sumberdata penelitian adalah unsur pimpinan, para guru yang mengajar tahfizh dengan teknik pengambilan sampel purposive random sampling.  Teknik pengumpulan data menggunakan wawancara dan dokumen.

Hasil penelitian adalah sebagai berikut: Study Komparatif paket program bahwa kedua Rumah Tahfizh tersebut dapat diambil kesimpulan bahwa Rumah Tahfizh Mardhiana Ibrahim hanya punya satu program Yaitu Program Tahfizh saja, sedangkan pada Rumah Tahfizh MTQM ada tiga Program yaitu Program Tahfizh, program Tahmidy dan Program Abata.  Study Komparatif penggunaan metode pada kedua Rumah Tahfizh dapat diambil kesimpulan bahwa pada Rumah Tahfizh Mardhiana Ibrahim hanya ada satu metode yaitu metode Sima’I, sedang pada MTQM ada tiga yaitu Metode Tikrar, metode Talkin dan metode talakki. Study Komparatif penggunaan media, bahwa kedua Rumah Tahfizh, dapet diambil kesimpulan bahwa media yang digunakan pada Rumah Tahfizh Mardiana Ibrahim adalah Video dan atau Video Call, sedangkan pada MTQM, disamping menggunakan video rekaman dan video call, juga menggunakan buku penghubung anatara guru dengan santri dan antara Guru dengan wali santri.  Study Komparatif evaluasi program, bahwa kedua rumah tahfizh sama melaksanakan evaluasi mingguan, semesteran dan tahunan.  Problematika yang dihadapi pada Rumah-rumah Tahfizh, bahwa kedua Rumah Tahfizh dapat disimpulkan bahwa problematika yang dihadapi Rumah Tahfizh berasal dari masalah santri yang kurang serius, lemah bacaan, banyak beban tugas di sekolah formal dan kurangnya dukungan dari wali santri.
KERJASAMA ORANGTUA DAN PENGELOLA DALAM PENYELENGGARAAN MADRASAH DINIYAH TAKMILIYAH AWALIYAH (MDTA) AISYIYAH TAROK DIPO KOTA BUKITTINGGI
Authors: Wirman Hanizon
Published: December 2022

Kecendrungan masyarakat melanjutkan pendidikan anak di MDTA atau TPA sebagai langkah awal dalam mendidik anak untuk mengenal dan mengerti tentang kandungan isi al Qur‟an tidak lagi menjadi fokus orang tua dalam membangun karakter dan spiritual. Untuk masalah pendidikan, orang tua mencari pendidikan di MDTA pilihan dan menjadi kegiatan yang menunjang pada pembelajaran di sekolah sebagai prioritas. Sebut saja perhatian lebih tercurah terhadap pendidikan luar sekolah seperti les bahasa Inggris, matematika, dan lainnya. Dari sekian banyak MDTA yang ada dikota Bukittinggi maka penulis meneliti MDTA Aisyiyah Tarok Dipo Kota Bukittinggi.
Intrusion Detection: A Review
Authors: Aljanabi Mohammad , Mohd Arfian Ismail  , Raed Abdulkareem Hasan  , Junaida Sulaiman
Published: December 2022

Due to the processes involved in the electronic transformation of data, computer systems, and the Internet have led to significant security, privacy, and confidentiality issues in recent years. Intrusion detection systems (IDSs) are one of the most promising data and network protection tools; there are many approaches and techniques used for the detection of intrusions based on the intrusion type; in this paper, different types of intrusions are reviewed, and the different kinds of systems for detecting intrusions, challenges and future directions for researchers determined at the end of this paper.
Major project management factors affecting the delivery of green building projects: The case of Jordan
Authors: Mukattash Mais , Hyarat Esraa
Published: December 2022

Construction projects have significant impacts on the environment. They adversely affect many areas, such as energy consumption, global warming and resource depletion. Green buildings have been found to be the most effective way to reduce these impacts. As a developing country with limited resources, Jordan is giving too much prominence to sustainability in construction projects. However, moving forward with Green Building Projects (GBPs) is a great challenge. Most managers do not have much experience in managing these projects yet. They are not fully aware of the importance of project management factors which can significantly affect the delivery process of GBPs. Research addressing these factors has become a crucial need in the construction industry. The main objective of this study is to identify the major project management factors required to deliver GBPs successfully in Jordan. The questionnaire was distributed to determine the significance of nineteen project management factors and SPSS software was utilized to perform the data analysis. The results show that for GBPs in Jordan to be successfully delivered, there must be clear lines of communication during the design and planning stages. The study concludes with recommendations for improving GBP distribution in Jordan. A further detailed study is needed to investigate and improve communication channels in GBPs. The practical implications of this study are to help the stakeholders in the construction industry understand management activities in the green building industry in a better and more realistic way. In addition, identifying these factors will help control future projects and ensure correct decisions are made from the beginning of the project to maximize the project's success.
La transformación digital en la educación superior: el caso de la UOC
Authors: Romero Marc , Romeu Teresa , Guitert Montse , Baztán Pablo
Published: December 2022

La pandemia ocasionada por el COVID-19 ha acelerado la integración del aprendizaje en línea en la educación superior (ES), y las universidades deben adaptarse a un escenario de no presencialidad hacia sistemas de aprendizaje híbridos. La transformación digital es un proceso que deben llevar a cabo las universidades y que requiere cambios sustanciales y estratégicos en prácticamente todos sus procesos. En este artículo se presenta el caso de una universidad creada y desarrollada en línea y cuyas experiencias pueden ser útiles a otras universidades que quieran emprender un camino similar. La investigación realizada se enmarca en el proyecto europeo "Empower Competences for Onlife Learning in HE'' (ECOLHE), desarrollado a través de un consorcio de instituciones de Italia, Grecia, Irlanda, Chipre y Cataluña. En el estudio presentado se aplican diferentes instrumentos de recogida de información como entrevistas en profundidad con responsables académicos, organización de grupos de discusión con profesores-investigadores, profesores/tutores, así como personal administrativo y técnico y un cuestionario online dirigido a los alumnos. En este trabajo se presentan diferentes visiones sobre los principales elementos y dificultades de una universidad digitalizada destacando que la tecnología debe ser una forma de mejorar la enseñanza, la investigación y el intercambio de conocimiento y que cambiar de un sistema tradicional presencial a un sistema en línea o híbrido no consiste únicamente en implementar la tecnología. Se aportan además una serie de conclusiones y lecciones aprendidas que pueden ser consideradas a la hora de iniciar un proceso de transformación digital en la ES.
Pedagogical Models Based on Transversal Digital Competences in Distance Learning: Creation Parameters
Authors: Araújo da Silva Ketia Kellen , Alejandra Behar Patricia
Published: December 2022

This article presents an investigation to define the parameters that guide the construction of pedagogical models (PM) based on transversal digital competences (DC) for distance learning (DL). A qualitative research approach was implemented in three stages: 1. a theoretical survey to build the initial parameters; 2. a case study of a course with teachers to apply the initial parameters; and 3. definition of the final parameters based on data comparison and analysis. A relationship was established between the concepts of pedagogical models, digital competences, and distance learning. Data was collected through questionnaires, interactions, and activities carried out during the course, which made it possible to identify the teachers' profile and the parameters for the pedagogical model based on digital competences. The data was analyzed, categorized, and treated for interpretation. Two categories were defined: pedagogical model to construct the digital competences and digital competences in distance learning. As a result, parameters were defined, in a framework, to assist in the construction of a pedagogic model based on digital competences in a gradual, integrated, and transversal way that can be used in any distance learning area, course, or discipline. The results of this work demonstrate that the proper construction of a PM consists in properly using technological tools based on digital competences. Furthermore, teachers must gain competences through training. This new approach, treating digital competences as transversal in the pedagogical model and its inclusion in institutional educational systems, aims at fostering teacher training through the construction of digital competences in education.
Psychological Stress and Perceived Self-Efficacy in Mothers of Autistic Children
Authors: Azeem Mubarak Doaa Mohammed Abdul
Published: December 2022

Background: Literature has indicated that parents of autistic children face higher stress levels than parents of allistic children (non-autistic children), leading them to experience depressive symptoms that impact their daily lives, reducing their quality of life. This study aims to investigate the relationship between psychological stress and perceived self-efficacy in mothers and fathers of autistic children.

Methods: This study is descriptive and cross-sectional. A total of 125 mothers and fathers consented to participate in the current study. 15 parents only partially completed the survey, so their data was not included. The remaining 110 cases were included. This left a final sample of 110 parents of autistic children, 100 mothers (90.9 %), and 10 fathers (9.1%). All were biological parents.

Results: As indicated by the results, all statements in the Parental distress (PD) subscale had a score ranging between high (the majority of items, 10) to medium (two items). All statements in the Parent-Child Dysfunctional interaction (P-CDI) subscale had a score ranging between high (the majority of items, 10) to low (two items). All statements in the Difficult Child (DC) subscale scored high. The whole subscale had a mean score of 4.04 (SD=3.17) with a high score. For correlations, psychological stress was negatively correlated with perceived self-efficacy (r = -0. 34, p < 0.001).

Conclusion: The stress experienced during the nurturing of children with disabilities is a factor that threatens the psychological well-being of mothers of autistic children.
Review of Managing Data for Patron Privacy: Comprehensive Strategies for Libraries by Kristin Briney and Becky Yoose
Authors: Dolan Levi
Published: December 2022

This review critiques Managing Data for Patron Privacy: Comprehensive Strategies for Libraries by Kristin Briney and Becky Yoose. Briney and Yoose's book structures considerations for patron data privacy around the data lifecycle, utilizing data management concepts. It addresses a selection of areas where librarians can introduce protocols for minimizing data breach risks through improving data management skills. In the broader context of library data stakeholders, it situates library policy and training through practical guidance and scenario-based examples.
La responsabilidad por actuaciones colectivas: una propuesta bratmaniana
Authors: Fernández Jose Manuel
Published: December 2022

Este ensayo busca identificar las condiciones bajo las cuales se puede establecer la responsabilidad en casos de actuaciones colectivas, específicamente cuando estas dan lugar a juicios justificados de responsabilidad simétrica. Establecer la responsabilidad supone una respuesta a la pregunta de qué es una actuación colectiva. Sin embargo, como muestra la discusión de dos casos, no hay claridad en cuanto a la respuesta a esa pregunta ni la importancia de responderla. Se argumenta que las actuaciones colectivas, según el modelo de Bratman, pueden entenderse como intenciones compartidas que conducen a una actividad compartida. La investigación concluye mostrando que este modelo puede responder precisamente a qué es una actuación colectiva y cómo los juicios de responsabilidad simétrica dependen de su satisfacción.
Automated hippocampal unfolding for morphometry and subfield segmentation with HippUnfold
Authors: DeKraker Jordan , Haast Roy AM , Yousif Mohamed D , Karat Bradley , Lau Jonathan C , Köhler Stefan , Khan Ali R
Published: December 2022

Like neocortical structures, the archicortical hippocampus differs in its folding patterns across individuals. Here, we present an automated and robust BIDS-App, HippUnfold, for defining and indexing individual-specific hippocampal folding in MRI, analogous to popular tools used in neocortical reconstruction. Such tailoring is critical for inter-individual alignment, with topology serving as the basis for homology. This topological framework enables qualitatively new analyses of morphological and laminar structure in the hippocampus or its subfields. It is critical for refining current neuroimaging analyses at a meso- as well as micro-scale. HippUnfold uses state-of-the-art deep learning combined with previously developed topological constraints to generate uniquely folded surfaces to fit a given subject’s hippocampal conformation. It is designed to work with commonly employed sub-millimetric MRI acquisitions, with possible extension to microscopic resolution. In this paper, we describe the power of HippUnfold in feature extraction, and highlight its unique value compared to several extant hippocampal subfield analysis methods.
Neural representations of naturalistic events are updated as our understanding of the past changes
Authors: Zadbood Asieh , Nastase Samuel , Chen Janice , Norman Kenneth A , Hasson Uri
Published: December 2022

The brain actively reshapes our understanding of past events in light of new incoming information. In the current study, we ask how the brain supports this updating process during the encoding and recall of naturalistic stimuli. One group of participants watched a movie (‘The Sixth Sense’) with a cinematic ‘twist’ at the end that dramatically changed the interpretation of previous events. Next, participants were asked to verbally recall the movie events, taking into account the new ‘twist’ information. Most participants updated their recall to incorporate the twist. Two additional groups recalled the movie without having to update their memories during recall: one group never saw the twist; another group was exposed to the twist prior to the beginning of the movie, and thus the twist information was incorporated both during encoding and recall. We found that providing participants with information about the twist beforehand altered neural response patterns during movie-viewing in the default mode network (DMN). Moreover, presenting participants with the twist at the end of the movie changed the neural representation of the previously-encoded information during recall in a subset of DMN regions. Further evidence for this transformation was obtained by comparing the neural activation patterns during encoding and recall and correlating them with behavioral signatures of memory updating. Our results demonstrate that neural representations of past events encoded in the DMN are dynamically integrated with new information that reshapes our understanding in natural contexts.
Det er trøst i regnbuens farger - omgivelsenes trøstende funksjon i sykepleien
Authors: Kitzmüller Gabriele
Published: December 2022

I dette essayet vil jeg belyse fenomenet trøst i sykepleien. Jeg tar utgangspunkt i min erfaring som pårørende til en kjær venninne som tilbragte sine siste dager på sykehus. Personalet på avdelingen ga oss anledning til å sette et hjemlig preg på hennes sykerom. Atmosfæren i dette rommet gjorde at vi som var der, følte trygghet, ro og velvære til tross for alvoret i situasjonen. Dette gjorde oss mere åpen for hverandre, ga oss trøst og bidro til en verdig avskjed. I essayet vil jeg reflektere over hvordan våre romlige omgivelser og naturens helende kraft kan bidra til at både pasient, pårørende og pleiepersonale føler seg hjemme, selv ansikt til ansikt med døden.
Estimert insidens av kronisk utmattelsessyndrom/myalgisk encefalopati i Norge mellom 2016-2018
Authors: Hilland Geir Haakon , Sarheim Anthun Kjartan
Published: December 2022

Kronisk utmattelsessyndrom/myalgisk encefalopati (CFS/ME) er en kompleks og kronisk sykdom som er assosiert med en betydelig reduksjon i livskvalitet for de rammede. I denne studien estimerer vi insidensraten for ME i den norske befolkningen mellom 2016 og 2018. Data om pasienter er innsamlet fra Norsk pasientregister (NPR). Populasjonen er definert av alle pasienter behandlet i spesialisthelsetjenesten som har blitt diagnostisert med CFS/ME mellom 2016-2018. Vi finner at 5 556 nye pasienter ble diagnostisert med CFS/ME i perioden 2016-2018. Insidensraten var på 36.1 per 100 000 person-år. Av disse var 4 347 kvinner, som betyr at insidensraten for kvinner relativt til menn var 3.7. Vi finner at forekomsten av CFS/ME varierer med alder, og vi finner to alderstopper i gruppene 15-19 og 35-39 år. Vi finner høyere insidens for den samlede populasjonen, sammenlignet med tidligere norsk forskning.
Cruise CAGE-18-4
Authors: Bünz Stefan
Published: December 2022

Cruise CAGE18-4 with UiT’s research vessel R/V Helmer Hanssen was carried out to collect cross-disciplinary data for addressing the objectives of the Norwegian Centre of Excellence for Arctic Gas Hydrate, Environment and Climate, CAGE. The cruise was split into two legs with a port call in Longyearbyen.
Leg 1 targeted the Vestnesa Ridge on the western Svalbard margin and acquired 2D and 3D high-resolution P-Cable seismic data in close proximity to the Molloy Ridge in order to better understand tectonic impacts on fluid flow and gas hydrate accumulations.
Leg 2 continued our investigations of the newly discovered gas seepage field in the Leierdjupet Fault complex (see CAGE17-3 cruise report) focusing on a better understanding of its complex leakage and source-to-sink plumbing system using seafloor photo and video imagery, water and sediment sampling, multibeam mapping and hydroacoustics.
The cruise may be known as: CAGE18_4
Keskkonnakaitse autoritaarsetes ühiskondades / Environmental Protection in Authoritarian Societies
Authors: Pál Viktor
Published: December 2022

Artikkel käsitleb riigi sekkumist keskkonnaprobleemidesse autoritaarse riigikorraga riikides, tuues võrdluseks ka näiteid liberaalsetest demokraatiatest 20. sajandi teisel poolel. Keskkonnast kõnelemisel ökoloogiliste argumentide asemel majanduslikele kaalutlustele rõhumine on võte, mida on kasutatud mõlemal pool nn raudset eesriiet. Üksiknäidetena käsitleb artikkel Reini jõe reostust Lääne-Saksamaal, Ladina-Ameerikast Guatemala ja Tšiili juhtumeid, kus eri argumentide toel on autoritaarsed võimud olnud huvitatud džunglite muutmisest keelualadeks. Keskkonna kahjustamist tarbimise kaudu esindab Tallinna Limonaaditehase juhtum. Sotsialistliku Ungari näitel analüüsitakse moodsate reoveepuhastussüsteemide ehitust ning nende rakendamist propagandavankri ette.

Summary

This article discusses the complex relationships between the natural environment and authoritarian governments in comparison to addressing similar problems in liberal democracies during the second half of the 20th century. A brief survey of the main theoretical sources is provided. Emphasising economic instead of ecological arguments in addressing environmental problems is a method that has been used on both sides of the Iron curtain of the Cold War.

Individual cases discussed include the management of the pollution of Rhein river in Western Germany, establishing of jungle areas as no-go-zones by the Guatemalan and Chilean juntas, but also Hungarian cases of the construction of wastewater treatment plants and the shortcomings in the production in Tallinn Lemonade Factory. The individual cases are related to a broader context of environmentalism to study how and why authoritarian and democratic governments have used technology and propaganda to promote the conservation of natural resources. In conclusion, this article aims to explain how and why various approaches under various political and economic circumstances to mend the environment eventually failed.
Addressing religious hate online: from taxonomy creation to automated detection
Authors: Ramponi Alan , Testa Benedetta , Tonelli Sara , Jezek Elisabetta
Published: December 2022

Abusive language in online social media is a pervasive and harmful phenomenon which calls for automatic computational approaches to be successfully contained. Previous studies have introduced corpora and natural language processing approaches for specific kinds of online abuse, mainly focusing on misogyny and racism. A current underexplored area in this context is religious hate, for which efforts in data and methods to date have been rather scattered. This is exacerbated by different annotation schemes that available datasets use, which inevitably lead to poor repurposing of data in wider contexts. Furthermore, religious hate is very much dependent on country-specific factors, including the presence and visibility of religious minorities, societal issues, historical background, and current political decisions. Motivated by the lack of annotated data specifically tailoring religion and the poor interoperability of current datasets, in this article we propose a fine-grained labeling scheme for religious hate speech detection. Such scheme lies on a wider and highly-interoperable taxonomy of abusive language, and covers the three main monotheistic religions: Judaism, Christianity and Islam. Moreover, we introduce a Twitter dataset in two languages—English and Italian—that has been annotated following the proposed annotation scheme. We experiment with several classification algorithms on the annotated dataset, from traditional machine learning classifiers to recent transformer-based language models, assessing the difficulty of two tasks: abusive language detection and religious hate speech detection. Finally, we investigate the cross-lingual transferability of multilingual models on the tasks, shedding light on the viability of repurposing our dataset for religious hate speech detection on low-resource languages. We release the annotated data and publicly distribute the code for our classification experiments at https://github.com/dhfbk/religious-hate-speech.
Comparison of rule- and ordinary differential equation-based dynamic model of DARPP-32 signalling network
Authors: Wysocka Emilia M. , Page Matthew , Snowden James , Simpson T. Ian
Published: December 2022

Dynamic modelling has considerably improved our understanding of complex molecular mechanisms. Ordinary differential equations (ODEs) are the most detailed and popular approach to modelling the dynamics of molecular systems. However, their application in signalling networks, characterised by multi-state molecular complexes, can be prohibitive. Contemporary modelling methods, such as rule- based (RB) modelling, have addressed these issues. The advantages of RB modelling over ODEs have been presented and discussed in numerous reviews. In this study, we conduct a direct comparison of the time courses of a molecular system founded on the same reaction network but encoded in the two frameworks. To make such a comparison, a set of reactions that underlie an ODE model was manually encoded in the Kappa language, one of the RB implementations. A comparison of the models was performed at the level of model specification and dynamics, acquired through model simulations. In line with previous reports, we confirm that the Kappa model recapitulates the general dynamics of its ODE counterpart with minor differences. These occur when molecules have multiple sites binding the same interactor. Furthermore, activation of these molecules in the RB model is slower than in the ODE one. As reported for other molecular systems, we find that, also for the DARPP-32 reaction network, the RB representation offers a more expressive and flexible syntax that facilitates access to fine details of the model, easing model reuse. In parallel with these analyses, we report a refactored model of the DARPP-32 interaction network that can serve as a canvas for the development of more complex dynamic models to study this important molecular system.
Embryonic exposure to fentanyl induces behavioral changes and neurotoxicity in zebrafish larvae
Authors: Wang Binjie , Chen Jiale , Sheng Zhong , Lian Wanting , Wu Yuanzhao , Liu Meng
Published: December 2022

The use of fentanyl during pregnancy, whether by prescription or illicit use, may result in high blood levels that pose an early risk to fetal development. However, little is known regarding the neurotoxicity that might arise from excessive fentanyl exposure in growing organisms, particularly drug-related withdrawal symptoms. In this study, zebrafish embryos were exposed to fentanyl solutions (0.1, 1, and 5 mg/L) for 5 days post fertilization (dpf), followed by a 5-day recovery period, and then the larvae were evaluated for photomotor response, anxiety behavior, shoaling behavior, aggression, social preference, and sensitization behavior. Fentanyl solutions at 1 and 5 mg/L induced elevated anxiety, decreased social preference and aggressiveness, and behavioral sensitization in zebrafish larvae. The expression of genes revealed that embryonic exposure to fentanyl caused substantial alterations in neural activity (bdnf, c-fos) and neuronal development and plasticity (npas4a, egr1, btg2, ier2a, vgf). These results suggest that fentanyl exposure during embryonic development is neurotoxic, highlighting the importance of zebrafish as an aquatic species in research on the neurobehavioral effects of opioids in vertebrates.
Identification of prognostic factors and nomogram model for patients with advanced lung cancer receiving immune checkpoint inhibitors
Authors: Chen Xiuqiong , Li Zhaona , Zhou Jing , Wei Qianhui , Wang Xinyue , Jiang Richeng
Published: December 2022

Background and aim

Some patients with lung cancer can benefit from immunotherapy, but the biomarkers that predict immunotherapy response were not well defined. Baseline characteristic of patients may be the most convenient and effective markers. Therefore, our study was designed to explore the association between baseline characteristics of patients with lung cancer and the efficacy of immunotherapy.

Methods

A total of 216 lung cancer patients from Tianjin Medical University Cancer Institute & Hospital who received immunotherapy between 2017 and 2021 were included in the retrospective analysis. All baseline characteristic data were collected and then univariate log-rank analysis and multivariate COX regression analysis were performed. Kaplan–Meier analysis was used to evaluate patients’ progression-free survival (PFS). A nomogram based on significant biomarkers was constructed to predict PFS rate of patients receiving immunotherapy. We evaluated the prediction accuracy of nomogram using C-indices and calibration curves.

Results

Univariate analysis of all collected baseline factors showed that age, clinical stage, white blood cell (WBC), lymphocyte (LYM), monocyte (MON), eosinophils (AEC), hemoglobin (HB), lactate dehydrogenase (LDH), albumin (ALB) and treatment line were significantly associated with PFS after immunotherapy. Then these 10 risk factors were included in a multivariate regression analysis, which indicated that age (HR: 1.95, 95% CI [1.01–3.78], P = 0.048), MON (HR: 1.74, 95% CI [1.07–2.81], P = 0.025), LDH (HR: 0.59, 95% CI [0.36–0.95], P = 0.030), and line (HR: 0.57, 95% CI [0.35–0.94], P = 0.026) were significantly associated with PFS in patients with lung cancer receiving immunotherapy. Patients with higher ALB showed a greater trend of benefit compared with patients with lower ALB (HR: 1.58, 95% CI [0.94–2.66], P = 0.084). Patients aged ≥51 years, with high ALB, low LDH, first-line immunotherapy, and high MON had better response rates and clinical benefits. The nomogram based on age, ALB, MON, LDH, line was established to predict the prognosis of patients treated with immune checkpoint inhibitor (ICI). The C-index of training cohort and validation cohort were close, 0.71 and 0.75, respectively. The fitting degree of calibration curve was high, which confirmed the high prediction value of our nomogram.

Conclusion

Age, ALB, MON, LDH, line can be used as reliable predictive biomarkers for PFS, response rate and cancer control in patients with lung cancer receiving immunotherapy. The nomogram based on age, ALB, MON, LDH, line was of great significance for predicting 1-year-PFS, 2-year-PFS and 3-year-PFS in patients with advanced lung cancer treated with immunotherapy.
AN AYURVEDIC APPROACH TO BELL’S PALSY: A CASE REPORT Article Category: Case Reports
Authors: BS Praveen , Nanda Rashmi
Published: December 2022

Introduction: Bell’s palsy is a ubiquitous lower motor disorder primarily affecting facial symmetry. The onset of the disease is acute mainly and idiopathic. The line of treatment for Bell’s palsy includes steroids, antiviral drugs and physical therapies. Ardita is a vatananatmaja vyadhi which simulates Bell’s palsy in clinical presentation. The treatment principles of Ardita chikitsa can be effectively adopted in successfully managing Bell’s palsy. Materials and Methods: The present study reports the case of a 49-year-old female patient with symptoms of facial asymmetry and right-sided numbness for 15 days. The case was reported to OPD of Panchakarma, Alva’s Ayurveda Medical College, Moodbidri, Karnataka, India. The treatment adopted included sthanika abhyanga, pottali sveda and Marsha nasya, along with internal medicines during the hospital stay. During the follow-up period, sthanika abhyanga, panasa patra sveda, shiropichu and pratimarsha nasya, along with internal medicines, were advised. Result: Patient observed relief in numbness by 4th day of treatment. Marked improvement was noted in eye closure (90%), forehead frowning, and eyebrow rise on the 11th day. 100% relief was noted at the end of 2 months of follow-up. Conclusion: The treatment principles enumerated in Ayurveda have a high success rate in effectively managing Bell’s palsy. It not only fastens the pace of recovery but also could help decrease the chance of recurrence.
MYOPIA MANAGEMENT WITH AYURVEDIC OCULAR THERAPEUTICS: A CLINICAL STUDY
Authors: Shekar Veena , V Hamsaveni , K Sujatamma
Published: December 2022

An open-label double-arm randomised study was conducted to evaluate the efficacy of Drishtipradavarti Aschyotana (eye drops) with and without Mahatriphaladi ghrita Tarpana (a nourishing topical ocular therapy) in the management of simple myopia. The study was comprised of two groups with twenty subjects each. Group A subjects were administered Drishtipradavarti Aschyotana (eye drops), and subjects of group B were administered Drishtipradavarti Aschyotana and Mahatriphaladi ghrita Tarpana. The total duration of treatment in both groups was restricted to 90 days. Subjects under the age group of 18-25 years with refractive error up to - 6 D were included in the study; out of the 45 subjects registered for the study, 40 completed the treatment. The parameters, namely, visual acuity, clinical refraction, indistinct distant vision, headache and eye strain, were evaluated statistically before and after the treatment along with the axial length and corneal radius of curvature findings to observe if there is any reduction in axial length and corneal curvature, after the treatment. The results showed a statistically highly significant reduction in symptoms (p = < 0.001 and p = < 0.01) and visual acuity (p = < 0.001) and a significant reduction in clinical refraction (p = < 0.05) in both groups. Group B showed comparatively better results. No significant changes were noticed in axial length and corneal radius of curvature values after the treatment (p = > 0.05). The results indicate that this Ayurvedic management can be utilised as a safe and potent treatment to control Myopia.
SAFETY PROFILE OF CHAPALA BHASMA WITH SPECIAL REFERENCE TO BISMUTH AND SELENIUM
Authors: Mathad Prasanna , Pandya MR , JL Arathi Chandran
Published: December 2022

Rasashastra is the branch of elemental biology in Ayurveda and has utilized almost every substance in nature, ranging from simplest forms like mud, fossils, and resin, to the most precious things like gold, gems etc. Chapala is a rasa dravya included in the group of Maharasa. It is a controversial drug, some authors consider Chapala as Bismuth, and some believe it is Selenium. So, to resolve the controversy of Chapala, a study has been conducted. Aim: To understand the Safety profile of Chapala bhasma (clax) with reference to Bismuth and Selenium through oral toxicity study. Material and Methods: Clax of Bismuth and Selenium, and the study was carried out according to the OECD guidelines. Results: Bismuth Clax has shown considerable changes in histopathology reports and fewer changes in Selenium clax. Conclusion: The Chapala bhasma prepared by Bismuth and Selenium was nontoxic, and Selenium clax showed more safety profile than Bismuth clax.
THE CONCEPTUAL STUDY ON YANTRA: A REVIEW
Authors: Aradhyamath Siddayya , PP Aiyanna , S Samtha
Published: December 2022

Yantras are inevitable parts of all minor and major surgical procedures. In surgeries and even in wound cleaning, we need yantras to take a sterilised gauze piece. This article throws light on the ancient yantras which have been used in the olden days. An attempt has been made to compile the Yantras mentioned in the Sushruta Samhita and Ashtanga Hridaya. The different types of yantras, like Swastika yantra, Samdamsa yantra, Tala yantra, Nadi yantra, and Upayantra, are being told in this article in addition to those mentioned in Ashtanga Hridaya.
Comprehensive Selection Criteria for Some Barley Genotypes under Different Water Stress Treatments
Authors: Mariey Samah A. , Khatab Ismael A. , Shahein Alaa M. E. A. , Abo-Marzoka EL-Sayed A. , Noreldin Tahany , Badawy Asmaa F. , El-Naggar A. A.
Published: December 2022

Nowadays, water scarcity is a great danger to agriculture development, in semiarid and arid regions beside climate change risks. Egypt is suffering from scarce water resources for agriculture; it is of high priority to rationalize irrigation water use. During two seasons, 2019/2020 and 2020/2021 the experimental were carried out to investigate the effect of three different irrigation water treatments (I1 at 45, I2 at 60 and I3 at 75% depletion of available soil moisture) on some photosynthetic, agronomical, grain quality parameters, water productivity for eight barley genotypes. Also, classify them on the SSR molecular level. The results showed that there were high genetic variations found among the eight genotypes with significant responses to irrigation water treatments. Rationalize irrigation water from I1 to I3 had a negative effect on all studied phenotypic traits, whereas had an appositive effect on leaf diffusive resistance and cured protein content and  inducement all genotypes to flower early by average increasing (27.7, 12.7 and 7.08%) respectively. Giza 138, Giza 131, and Line 4  gave high mean performance values of the measured characters besides, attaining high WP values were 1.14, 1.08, and 0.89 kg grain/m3 applied water I1, I2, and I3 irrigation treatments, respectively. While, WUE values increased with increasing water availability. Water use efficiency values were 1.92, 1.71, and 1.34 kg grain/m3 consumed water for I1, I2, and I3 irrigation treatments, respectively. Twenty-six alleles were generated using ten SSR primers with a mean value of 2.6 alleles per locus. The Polymorphism Information Content (PIC) value of each SSRs marker ranged from 0.33 (Bmag 0387) to 0.47 (Bmac 0167) with an average value of 0.34. Cluster analysis clustered the eight barley genotypes into two major clusters divided according to their response to water stress tolerance. The genetic information about eight barley genotypes for water stress tolerance was established, for use them in breeding programs in Egypt.
Post Harvest Treatments and Shelf Life of Some Tropical Fruit
Authors: Feyera Milkesa , Abdo Tseganesh
Published: December 2022

Fruits are perishable horticultural crops grown in tropical and sub-tropical areas of the world. It is a richest source of micro nutrients and phyto chemicals that contributed a significant role in human health. Mango, avocado, papaya, guava and pine apple are popular and economically important tropical fruits due to their essential nutritional properties and appreciated eating quality. However, in developing countries, upto 50% of those fruits are lost after harvest due to improper post-harvest handling practices. Edible coating, dip in calcium chloride solution, hot water treatment and drying are easily applicable post harvest treatments used in the preservation of such tropical fruits. Shelf life of mangoes coated using edible coating material can be extended up to 18 days without rotting and developing unpleasant-flavour relative to coated guava, papaya, avocado and pine apple fruits. Dipping harvested fruits in various concentration of calcium chloride solution exhibited different storage life. Consequently, mango fruits treated with 10% of calcium chloride solution preserved for 30 days at 12°C and 85-90% relative humidity. Guava fruits treated by hot water at 45oC for 3 minute lasts upto 31 days under room temperature. In this review maximum shelf life up to 9 months was found for Avocado fruit dried using freeze drying method.
In silico Screening of Potential Compounds from Medicinal Plants by Targeting Streptococcus mutans Deoxycytidylate Deaminase
Authors: Pundir Hemlata , Pant Tanuja , Pathak Ramanand , Pant Manish , Chandra Subhash , Tamta Sushma
Published: December 2022

Dental caries is the chronic infectious disease caused by bacteria to from a biofilm formation on the tooth surface of man. Drug-resistant Streptococcus mutans (S. mutans) poses a vital public health issue. To overcome this, the development of effective drugs with novel mechanism of action is requisite. Drug repurposing is considered a viable alternative approach to overcome the above issue. In the present study, we have attempted to selected unique and traditional source use as in traditional medicine. Traditionally, many cultures use chewing sticks for oral hygiene maintenance. When properly used, these chewing sticks are found to be efficient due to the combined effect of mechanical cleaning, enhanced salivation and the antimicrobial action of leached out plant. Inibition of the S. mutans deoxycytidylate deaminases (SmdCDs) is the most promising drug development strategy against the S. mutans, responsible for the biofilm formation. In the present work, out of 871 phytochemicals 211 phytochemicals were showed the most druggable substance with zero violation from any of druglikeness rule. Further, the binding energy indicates the affinity of the adhesion of protein structure docked with the 2 hit potential herbal compounds of which Cyclocurcumin and Androsta-1,4,6-triene-3,17-dione showed best docking with the SmdCD.
Cultural Representation of Chinese-Indonesians in Ca Bau Kan (The Courtesan) in the Context of Spice Trading and Nationalism
Authors: Sutandio Anton , Arifin Yohan Yusuf
Published: December 2022

The object of this research is Nia Dinata’s film, Ca Bau Kan, which was adapted from Remy Sylado’s novel. The research focuses on the representation of Chinese-Indonesians which pertains to the context of the maritime spice trade route and the concept of nationalism. Set in Batavia in three different decades, namely the 1930s, 1940s, and 1960s, the film depicts the journey of a Chinese-Indonesian character from the Dutch colonial era and the Japanese colonial era to the era of the independence revolution. The research method used is a qualitative method through the theory of film studies, which is juxtaposed with the historical approach to see how Chinese-Indonesians are represented in the film. The findings show that the film attempts to represent the Chinese-Indonesians accurately, albeit with the continuous presence of inaccurate stereotypes. The findings show Chinese-Indonesians’ economic contribution that reflects the history of the spice trade maritime route in Indonesia.
Micrometer‐Scale Optical Web Made of Spider Dragline Fibers with Optical Gate Operations
Authors: Hendra  , Yamagishi Hiroshi , Heah Wey Yih , Malay Ali D. , Numata Keiji , Yamamoto Yohei
Published: December 2022

Dragline silk fibers produced by spiders are a masterpiece structural protein that is durable even in the wild conditions. Dragline silk fibers are known to have excellent mechanical toughness and flexibility and further possess optical transparency, which are highly promising as textiles, sensors, and optical devices. Here, the authors show that the dragline silk microfibers act as good optical waveguides with the optical loss coefficient as small as 0.03 decibel per micrometer. The light transportation in the dragline silk fiber is performed by fluorescence energy transfer between two microspheres located on a suspended dragline silk microfiber. By utilizing a micromanipulation equipment, micrometer‐scale spider web‐like structures are fabricated. The experimentally observed optical waveguiding properties of the weaves match well with simulation results using simple mathematical models. Furthermore, optical logic gate operations are demonstrated using photoswitchable microsphere resonators attached on the dragline fibers.
Arbitrary Polarization Readout with Dual‐Channel Neuro‐Metasurfaces
Authors: Wang Zhedong , Qian Chao , Fan Zhixiang , Chen Hongsheng
Published: December 2022

Polarization, as a vector nature of the electromagnetic wave, plays a fundamental role in optics. Determining the polarization state of light is required by many applications, spanning from remote sensing and material analysis to biology and microscopy. To achieve this goal, conventional methods necessitate cascading of multiple optical components and consequential measurements to estimate the Stokes parameters, rendering the entire optical system bulky, complex, and sensitive. Here a brand‐new strategy is introduced for direct polarization readout based on dual‐channel neuro‐metasurfaces. Neuro‐metasurfaces can independently manipulate two orthogonal linearly‐polarized waves that can synthesize arbitrary polarization waves with a linear combination. By judiciously designing the output focus points, a unique polarization atlas is created that allows one‐to‐one correspondence from intensity ratio to polarization state. To implement this, polarization‐sensitive metasurfaces are designed and the spatial layout is optimized using a diffractive neural network. The feasibility of this strategy is validated by numerical simulation and microwave experiments. These results pave a new avenue in realizing integrated and multifunctional detectors and demonstrate the potential of neuro‐metasurfaces as an add‐on for discomposing and composing spatial basis.
Ein Verbindung‐I‐Analogon deckt die vorübergehende aktive Spezies eines Zytochrom‐P450‐Enzymes auf: Einblick in die Stereoselektivität P450‐katalysierter Oxidationen
Authors: Suzuki Kazuto , Stanfield Joshua Kyle , Omura Keita , Shisaka Yuma , Ariyasu Shinya , Kasai Chie , Aiba Yuichiro , Sugimoto Hiroshi , Shoji Osami
Published: December 2022

Das Erfassen der Struktur von Zytochrom‐P450‐Enzymenin flagrantiist für die Entwicklung von P450‐Biokatalysatoren von entscheidender Bedeutung, da die meisten der bisher erfassten Strukturen in einer präkatalytischen Konformation gefangen sind. Das Herzstück der P450‐Katalyse ist Verbindung I (Vbd I), ein kurzlebiges, hochreaktives Zwischenprodukt, dessen widerspenstige Art die Mehrheit der Versuche vereitelt hat, katalytisch bedeutsame Konformationen von P450 zu erfassen. Wir zeigen die Kristallstruktur von P450BM3, die den Zustand genau im Momente vor der Epoxidierung nachahmt, der mit den experimentell ermittelten Stereoselektivitäten perfekt übereinstimmt. Die Kristallisation wurde durch Bindung des stabilen Vbd‐I‐Analogons Oxomolybdänmesoporphyrin IX an P450BM3 in Gegenwart Styrols erreicht. Die relative Ausrichtung Styrols zur Molybdän‐Sauerstoff‐Spezies in den Kristallstrukturen wirft ein Licht auf die Dynamik, die an der Drehung Styrols beteiligt ist, um seine Vinylgruppe Vbd I darzubieten. Diese Methode dient als leistungsfähiges Instrument zur Vorhersage und Modellierung der Stereoselektivität von P450‐Reaktionen.