bluuebunny/crossref_metadata_2025 huggingface dataset:
Stem cell therapy in improving the motor function of patients with cerebral palsy: Systematic review with meta-analysis
Authors: Ahmad Hassan  , Umair Bin Nasir
Published: November 2024

Background: Cerebral palsy (CP) has no cure yet. This study was aimed to evaluate the efficacy and safety of stem cell therapy (SCT) for improving the gross motor function (GMF) of patients with CP.
Methods: A systematic literature search was performed in CENTRAL, PubMed, Embase, and Google Scholar to identify relevant randomized controlled trials from the year 2012 to 2022. The outcome measures were GMF and adverse events. For the meta-analysis, treatment effects on GMF improvement were expressed as standardized mean differences (SMD) with 95% confidence intervals (CI), using a random-effects model.
Results: There were seven trials that either used autologous or allogenic stem cells, with 411 participants, and were met with inclusion and exclusion criteria. The age, severity, and type of CP in participants varied. Follow up duration ranged from 6 to 24 months. Four studies had single transplantation while the other three had two to four sessions. Overall, a significant positive effect on GMF was seen in SCT than control group, SMD = 2.22 [95% CI 1.15 - 3.29] with a high heterogeneity (I² = 95%). In a separate analysis, umbilical cord blood (UCB) was the most effective cell type, SMD = 3.24 [1.38,5.10]. Serious adverse events were rare, with similar effects in treatment and control groups.
Conclusion: A positive and safe effect of SCT, specially UCB on GMF, was observed. However, the standardizations of treatment regimes, therapeutic-cell dose, and SCT optimal timing are needed to maximize the efficacy of treatment.
Keywords: Cell Therapy, cerebral palsy, efficacy, motor function, movement disorders, stem cell
In Silico docking of piperazin analog for non-small cell lung cancer having mutations in EGFR, ALK, and BRAF proteins.
Authors: Sajid Khan  , Faisal Nouroz
Published: November 2024

Background: Mutations in different genes like EGFR, ALK and BRAF are the sources of non-small cell lung cancer. Mutation of ALK occurs of small inversion on short arm of chromosome 2. The most commonly found EGFR mutations in patients with NSCLC are deletions in exon 29 or in exon 21. Common BRAF transversion mutations occur at exon 15. The missense mutations of BRAF have been detected in exon 11 and exon 15.
Objective: The objective of study was to design new chemical compounds to block the targeted sites for receptor proteins present on cells surface, which control the growth or stop the proliferation of cancer cells.
Methods: After screening large amount of data, we designed an in silico drug compound for lung cancer that block the mutations in EGFR, ALK and BRAF genes.
Results: We suggested a novel compound (7-[2-({6-[4-(chloromethyl) piperazin-l-yl] oxan-3-yl} amino) pyrimidin-5-yl]-octahydropyrano[2,3-c]pyridin-3-ol) to control mutations in EGFR, ALK and BRAF genes. Molecular formula of ligand compound C22H35C1N603 showed promising Lipinski rules of five values having Log P 0.58-1.86, molar refractivity 123.13 ± 0.3 cm3, H bond acceptors and donor 8 and 2 respectively. ALA, LYS, ARG were common interacting residues for EGFR, ALK genes and ALA, GLY were common for ALK, BRAF mutant genes and ligand complex interaction.
Conclusion: ALA was common among all interactions that showed less side effects and long resistance against non-small cell lung cancer.
Awareness of Dyslexia Among Primary School Teachers in Public and Private Setting in Lahore City, A Cross Section Survey
Authors: Iqra Mahnoor Gulzar
Published: November 2024

Objective: The purpose of the study was to examine the awareness of primary school teachers among public and private setting in Lahore about dyslexia and to explore the factors that might be related to better understanding of it.Methodology: It was a comparative cross-sectional study with total sample size of 100 teachers. Fifty public and fifty private primary school teachers in mainstream of Lahore were administered the questionnaire. A questionnaire was constructed based on the existing literature and data was analyzed using SPSS.Results: The results indicated that teachers' understanding of dyslexia varies greatly and there are gaps in their knowledge as well as misconceptions about this topic.Conclusions: The findings showed that there is lack of awareness concerning the strategies and intervention programmes for pupils with dyslexia. Finally, this dissertation makes recommendations concerning teachers' preparation as well as future research directions.Key words: Dyslexia, Primary School Teachers
ZAMONAVIY DUNYODA MA’NAVIY-MADANIY DEFORMATSIYALASHUVNI YUZAGA KELTIRUVCHI OMILLAR
Authors: Yazdonov Ulug‘bek , Sayidova Muhabbat
Published: November 2024

In this article, the global threats to national spiritual values, their manifestation characteristics, and movement mechanisms are considered, and the possibilities of preserving the material and spiritual heritage and passing on traditions to the next generation are analyzed socio-philosophically.
WORD BORROWING METHODS AND THEORETICAL FOUNDATIONS
Authors: Nazarova Gulbahor
Published: November 2024

This article explores the complex phenomenon of word borrowing in linguistics, emphasizing its multifaceted theoretical foundations and processes. It is highlighted the adaptation of borrowed words to the phonetic, semantic, grammatical, and orthographic systems of the receiving language.
Components of Social Maturity in Students
Authors: Nazokatkhon Rakhimova
Published: November 2024

This article provides an analysis of theories of social maturity, as put forth by numerous scholars, demonstrating the theoretical and practical significance of students' social maturity in contemporary society. The study presents an in-depth exploration of the concept of social maturity, including an individual's lifetime achievements, societal status, personal and professional accomplishments, philosophical perspective, notable character traits, and values. Moreover, this piece elucidates the phenomenon of social maturity, expounding upon its investigation via psychological research. It further sheds light on psychological external and internal factors influencing the student, psychological elements of social maturity, age-specific characteristics, processes of professional growth and adaptation, social maturity development, motivational aspects of career selection, and contemporary scientific psychological constructs of social maturity.
The Influence Of Allusive Names On The Perception Of Artistic Text
Authors: M.M.Kurbanova  , M.F.Xomidova
Published: November 2024

Allusive names are the most common intertextual units in literary texts. When using allusive names, the author must take into account the reader factor and the audience. Because in any historical period, in one or another country, culture, individuals, religious, mythological, and literary heroes, with their distinctive characters, occupy a place in the linguistic foundation of language users, thus become allusions. Over time, they are formed in the form of stable lexical units, and the person who hears or reads them has associations with these names. The author, who is able to use this in harmony with his text, communicates indirectly with the reader. That is, the author communicates with the existing information in the mind of the reader. The function of allusion as an intertext is visible here. Allusion is actively used both in classical artistic and modern texts. In particular, this type of intertextuality is very active in Alisher Navoi’s works. In this article, we analyze the effect of allusion as an intertext on the meaningful perception of the text based on experimental materials.
ON THE LITERARY TRADITIONS OF NAVOI IN THE WORKS OF KHOREZM POETESSES
Authors: N.F. Atajanova
Published: November 2024

This article accentuates the influence of Alisher Navoi's work on Khorezm poets, notably Ullibibi Otayeva, Gavhar Ibodullayeva, and Shaira Shams. Ibodullayeva's mukhammas in response to Navoi's ghazal, "Sen Mening," exhibits harmonisation of form and content, while Shams brings Navoi's complex thoughts in "Dost" to modern readers. Otayeva refines Navoi's concept in "Nasoyim ul-muhabbat," seen in Ibodullayeva's "Boldim" and Shams's "Aylasa" ghazals. The poets' works echo the traditions of Uzbek literature and Navoi's pervasive influence. Their artistic expression reveals shared imagery, as noted in Otayeva's analysis of Navoi’s ghazals and rubai in her work, "The Last Wish."
B2B Electronics Demand Forecast Model: PC Market Case
Authors: Bhuvanesh Kumar Sharma  , Sunaina Kuknor  , Sneha Rajput  , Aashish Mehra
Published: November 2024

Businesses want a trustworthy approach to estimate market demand due to the rising level of demanduncertainty in the B2B electronics sector. For a corporation to avoid producing too few or too many of itsproducts, which could have an effect on the performance of the business, an accurate estimation of the marketdemand is essential. However, given the wide variety of businesses in terms of size, industry, and mode ofoperation, it can be challenging to estimate demand in a B2B market, particularly for the private sector. ForB2B PC products, this study suggests using both qualitative and quantitative demand forecasting methods.Personal work, common work, promotion, and welfare are the four separate criteria for projecting PC productsin the B2B market while accounting for the variety of PC uses. These calculations are backed up by surveydata gathered from specialists in 139 companies, which may be applied when a specific company evaluatesthe demand for PC products in a B2B market. The multiple regression model, which has variables for area,industry, and company size, is the suggested quantitative approach. When it is necessary to estimate the wholedemand for the domestic PC market, the regression model may be used.
Factors Influencing Consumer Purchasing Behavior Regarding Luxury Brands
Authors: Vimalnath V  , Gururaj Phatak  , Pushpa Honga  , Vishal Kumar R  , Varsha Agarwal  , Guruprasad Ramakrishna Naik
Published: November 2024

The luxury market in India is undergoing rapid growth, driven by enriched earning salary and profits in bothurban and rural areas, a young demographic advantage, heightened visibility in retail, advertising, and greaterconsumer exposure. Factors such as fashion, lifestyle, social value, and the willingness to spend areinfluencing modern shoppers to purchase luxury brands to fulfil their psychological needs and boost theirself-esteem. Owning luxury merchandise has become a statement of one's essence. This research aimed todelve into the complex dynamics of consumer purchasing behavior (CPB) in relation to luxury brandedproducts. The study utilized several factors, including Materialism, Price-Quality considerations, SocialStatus aspirations, and Brand Trust, as independent variables, to examine their potential impact on thedependent variable, Consumer Buying Behavior (CBB). Data were collected through a well-designedstructured questionnaire distributed to 180 respondents who displayed a specific interest in luxury fashionclothing. The data collection process involved emailing the questionnaire to friends and colleagues, and theresponses were systematically gathered and analyzed using the statistical software SPSS. It is important tonote that the sample population of 180 respondents had limited diversity and may not fully represent the entirepopulation, indicating a scope for further improvement in future research endeavors.
Indic Elements in Laos, A Southeast Asian Country: A Historical Perspective
Authors: Prashant Dhage
Published: November 2024

This article is about the influence of Indian culture particularly on Laos, which has been a South East Asiancountry since ancient times and continues to be so today. There are numerous cultural parallels between Indiaand South East Asia. Over the centuries, various aspects of Indian culture have influenced the lives andcivilizations of people living in South East Asia. From the second century onward, the principalities thatemerged in the region witnessed the peaceful and non-political penetration of Indian culture. The local eliteand people went through a selection and rejection process of Indian elements. Laos represented Indianizedculture among South East Asian countries. Laotians have made significant advances in fields such as literature,religion, art, and architecture. Assimilation and diffusion occurred at all levels of society. Cultural elementsfrom various parts of India merged to form local cultural forms. The remainder of the population, includingKhmers and Thais, regard India as their primary source of cultural history and contemporary culture. Indicelements pervade their literature, which is written in Sanskrit and Pali scripts. Orissa temples influenced theirtemple architecture. Their devotion to the Ramayana, Jataka figures like Dadhivahana and Vimalaraja, and soon. It was not a case of Indians subduing Laos and imposing their culture. The Indian cultural superstructurewas built on an indigenous foundation. Geographically it is far away from India but culture shortened thedistance and made such a relation which can create a platform to fulfill the dream of the world is one family.
Formation of Mathematical Thinking Competence in Students as a Scientific Pedagogical Issue
Authors: Kenjayeva Sanobar Ibragimovna
Published: November 2024

School education is a part of the continuous education system that requires special attention. The door to allthe opportunities necessary to achieve the effectiveness of quality education on a global scale is being openedon a large scale. How to build a 21st century school system? such questions are also being considered at thelevel of global education policy. Systematic work is being carried out in the environment of digitalization ofeducation, introduction of the most advanced methods of teaching on the basis of digital technologies relatedto education and training, in accordance with the standards of world education. Today, global globalizationprocesses have an impact on the development of science, education, art, culture, sports, economy, business,marketing, construction industry, production, and so on. it is known to everyone. In particular, the processesof globalization have brought about important changes in the field of education. First of all, these arecharacterized by transformation processes, that is, deep, new qualitative changes in the quality, efficiency,structure, and functions of education. This article talks about the reasons why the development ofmathematical thinking competence is considered as a pedagogical problem and the methods of solving theproblem, as well as information about the opinions of scientists, types of thinking and existing problems inschool.
DIAGNÓSTICOS E AS POSSIBILIDADES DE TRATAMENTO DA DISLEXIA
Authors: Nyland Joana , Rocha Cristiane Martins , Carvalho Daniele Alves Benedito de , Martins Lais Barros , Ferreira Silvia Alecrim , Silva Erisnalva Pereira da , Gonçalves Patrícia Alvim Soares , Aquino Maria de Nazaré Alves de , Souza Elayne Alves Barbosa de , Telles Claucione Soares , Aquino Elizama Alves de , Silva Adriana Aparecida , Silva Eliana de Oliveira da
Published: November 2024

O presente estudo tem por objetivo analisar a Dislexia em sala de aula, e, elencar alguns tipos de tratamentos e possibilidades de auxílio, tanto pelos professores e equipe pedagógica em sala de aula, bem como dos profissionais das áreas de saúde que complementam um conjunto interdisciplinar de apoio à criança disléxica. Objetiva-se também auxiliar aos profissionais da área da educação, que estão diretamente ligados na rede escolar e que possa vir a ter o enfrentamento de se confrontar com um aluno com Dislexia, portanto, um apoio profissional. Para atingir as informações necessárias para a realização desta pesquisa, utilizou-se as referências bibliográficas, tendo como focos de evidência, a participação dos pais, a capacitação dos professores, a ação pedagógica específica para os alunos disléxicos, o tratamento específico com uma equipe multidisciplinar que envolve médico, fisioterapeuta, fonoaudiólogo, psicólogo, terapeuta ocupacional, pedagogo. Fica evidente neste estudo que a dislexia não tem cura, mas tem a possibilidade de dar à criança condições de ter uma vida saudável e através de processos pedagógicos eficientes dar vazão para outras potencialidades inatas da criança.
INTERVENÇÕES FISIOTERAPÊUTICAS PARA O CONTROLE DA DIÁSTASE ABDOMINAL NO PUERPÉRIO: UMA REVISÃO DE LITERATURA
Authors: Souza Thainá Coimbra da Silva de , Corrêa Ronald Batista , Duarte Thaiana Bezerra
Published: November 2024

Introdução: Durante a gestação, os músculos abdominais sofrem alterações biomecânicas para o crescimento uterino favorecendo o desenvolvimento do feto, ocasionando o afastamento dos músculos reto abdominais, definido como Diástase dos Músculos Reto Abdominais. A atuação da fisioterapia, contribui com o desenvolvimento de estratégias de prevenção e tratamento, que visa melhorar a tonicidade dos músculos abdominais e pélvicos, tendo como objetivo a melhora na qualidade de vida da puérpera. Objetivo: Discutir sobre as intervenções fisioterapêuticas utilizadas na literatura para redução da diástase, destacando, como o tratamento pode influenciar na qualidade de vida da puérpera, no aspecto de funcionalidade. Materiais e métodos: Trata-se de uma revisão de literatura, utilizando as bases de dados: Biblioteca Virtual de Saúde, Periódicos Capes, PudMed e Scielo. Utilizou-se os descritores de acordo com os idiomas inglês e português, além disso, foram incluídos na revisão, artigos de intervenção fisioterapêutica para o controle da diástase abdominal; que apresentavam disfunções associadas à diástase abdominal e que verifiquem a qualidade de vida da puérpera. Resultados: Foram incluídos 5 estudos em que os protocolos citados incluem a cinesioterapia, baseando-se em exercícios de fortalecimento de profundo decore, com contrações isométricas e isotônicas dos músculos abdominais e do assoalho pélvico e exercícios de propriocepção com as técnicas de Pilates, para a redução da diástase abdominal. Conclusão: A revisão dos estudos demonstrou que, embora as intervenções fisioterapêuticas apresentem resultados positivos, ainda não há protocolos suficientes para serem estabelecidos para utilização na prática clínica, e ainda, necessitando de mais estudos que possam compreender a relação entre a diástase e as alterações funcionais, afim de contribuir com a melhora na qualidade de vida da puérpera, no aspecto de funcionalidade.
Tech Horizons Unveiled: Navigating the Transformative Decade in AIML, Cybersecurity, IoT, Gaming, and Data Science Education
Authors: Raja A. S. Vignesh , Jasper K. Daniel , Poornima V. , Priscila S. Silvia , Thenmozhi A. , Ratkovic Nada
Published: November 2024

In the transformative landscape of the past decade, the integration of Artificial Intelligence and Machine Learning (AIML), Cybersecurity, the Internet of Things (IoT), Gaming Technology, and Data Science has redefined industries, employment, education, and corporate structures. This research explores the profound shifts in technology job roles, comparing the industry's state from a decade ago to its current dynamic form. The evolution of standardized roles into a spectrum of diversified designations reflects the dynamic nature of the contemporary tech job market, demanding a broader skill set. Education has witnessed a seismic shift, with students increasingly drawn to technology-centric courses, reflecting the alignment between educational choices and evolving job market demands. Corporations, recognizing the imperative of technological relevance, have transformed, introducing new roles and fostering adaptability. Ethical considerations have gained prominence, with roles addressing biases, societal impacts, and privacy concerns emerging. This exploration serves as a compass to navigate the ever-shifting landscape of technology job roles, educational pursuits, and corporate structures, chronicling profound changes and illuminating the path forward in an era where change is the only constant.
Why Offsites Work — and How to Get the Most Out of Them
Authors: Westover Jonathan
Published: November 2024

This practitioner-oriented brief explores why offsite meetings and retreats are an effective tool for driving organizational progress and shares best practices for maximizing their impact. Through an examination of relevant academic literature, the brief establishes that offsites create an environment sheltered from everyday workplace distractions that allows for deeper focus and stimulates novel perspectives. Research also shows offsites foster increased psychological safety and collaboration through extended engagement away from normal hierarchies. Drawing from over 15 years of management consulting experience, practical recommendations are then provided regarding objective-setting, venue selection, agenda crafting, facilitation, and follow-up. Real-world case examples from a global technology firm and aerospace supplier demonstrate successful application. The conclusion maintains that well-planned offsites, as informed by the research and best practices covered, have unmatched potential to accelerate strategic planning, problem-solving, team alignment, and organizational change versus standard meetings.
Sociological Aspects of Radicalization and Terrorism
Authors: Panchev Dimitar
Published: November 2024

The purpose of this paper is to examine the sociological aspects of the radicalization process, their underlying causes, and the processes associated with them. The various aspects of the problem of radicalization and its social roots will be presented through sociological theories and concepts such as socialization, convergent settings, social capital and resource networking, overlapping ecosystems, and their denser description will be supported by empirical research data and publicly available sources of information.
Експериментално изследване на тактическа стрелба във високорискови ситуации
Authors: Stanchev Ivan
Published: November 2024

Training in the "National Security" professional field includes disciplines that prepare for the performance of tasks in a complex environment. The risk to the life and health of officers of the national security protection system is part of the characteristics of the professions in this system. Training for high-risk operations, outside the National Military University and the Academy of the Ministry of Interior, is poorly represented and is mostly theoretical in nature. Scientific studies of high-risk operations are based on the use of primarily theoretical methods. The use of empirical methods to provide new knowledge is limited. The article presents an experimental study that determines basic characteristics of the use of firearms in typical confrontations with armed offenders. On the basis of the analysis of the results, conclusions are synthesized for the development of tactical shooting as an educational discipline, the methodology of which is based on the principles and rules of special police tactics.
Navigating Challenges Implementing India's NEP (2020) in Higher Education
Authors:   NIILM University Kaithal India, Neha Neha , Rohitash Rohitash ,   NIILM University Kaithal India
Published: November 2024

India's National Education Policy (NEP) 2020 is a revolutionary major in the country's higher education. However, the performance process is fraught with many problems. This research paper addresses the challenges faced by higher education institutions in India in translating the New Education Policy (2020) into practical strategies and training providers for problem-solving. While more than 7 million teachers are needed to meet the increasing number of students, the shortage of education workers is also increasing. There are not enough good teachers, we need better buildings and more technology. In an environment of stakeholder resistance and resource constraints, academic leadership and management face increasing challenges in promoting collaboration and shared ownership. Major investment in infrastructure is required, and education spending should be increased from 4.6% to 6% of GDP. In addition, lack of knowledge of regional languages and inequality in English language skills, as well as health problems and digital use, cause major problems, especially in rural and economically disadvantaged regions. It continues to explore the challenge of aligning curriculum with policy vision while addressing stakeholders and constraints. Additionally, our teaching method must comply with NEP (2020) requirements. Limited access to education and digital literacy in remote areas hinders the integration of technology and education. In addition, changing the behavior of teachers, students, and parents is important in terms of implementing new teaching methods and adapting the curriculum to changes. This paper provides administrators and educators with insight into how these issues can be addressed through research and real-life examples. Also, this paper offers policymakers, administrators, and educators insight and recommendations to address these issues. This aims to contribute to the debate on the implementation of NEP (2020) in Indian higher education by highlighting key areas that require attention and action.
Pembelajaran Interaktif dan Menyenangkan di Luar Lingkungan Sekolah Melalui Bimbingan Belajar Harian
Authors: Azizah Wilda , Nayaputri Devina Yasintha , Nabila Nur Qurratul , Sabila Arina Hasya , Laksono Ailsa Purwabhagawanta Saskirana , Simatupang Devona Valerie , Hikmawan Baso Didik , Junaidin Junaidin , Ahmad Islamudin
Published: November 2024

This study evaluated the effectiveness of a daily home-based learning program implemented in Rumah Pintar, Pantai Lango. The program aimed to improve the academic skills of children aged 3-12 years who were experiencing learning difficulties. The intervention, conducted from July 12 to August 2, 2024, provided a structured learning environment outside of school hours. Participants were divided into groups based on their academic levels, addressing needs ranging from basic literacy and numeracy to English language learning. Results indicated that the program was successful in enhancing participants' abilities in reading, writing, and mathematics. However, challenges such as fluctuating daily attendance, attributed to a lack of parental awareness about the importance of home learning, were encountered. Despite these challenges, the program demonstrated the potential of non-formal, home-based learning initiatives in addressing the educational needs of children in underserved areas.
Does ageing modulate interactions between mesothelioma cells, macrophages, and tumour endothelial cells?
Authors: Duong Lelinh , Jackaman Connie , Nelson Delia J
Published: November 2024

It is becoming increasingly clear that the tumour microenvironment (TME) adopts a changing and increasingly complex landscape as tumours evolve. Central to the TME, and alongside malignant cells, are tissue resident and recruited macrophages, other immune cells, and endothelial cells, with the latter critical for angiogenesis and tumour development. Tumour vessels provide oxygen and nutrients and are portals for immune cells. Tumour cells, immune cells and endothelial cells engage in multi-directional crosstalk that untimately influence tumour progression and treatment responses. Adding to complexity, the TME often consists of oxygenated, and oxygen deprived or hypoxic regions, with the latter significantly contributing to disease progression and treatment resistance. However, the function of immune cells and endothelial cells change with ageing, and this underexplored area likely influences the aged TME and disease outcomes in the elderly. Solid cancers such as mesothelioma with known carcinogen exposure (asbestos) take decades to reach a diagnosable size, often emerging in people aged 60 years or more. Here, we discuss the influence of ageing on the function of tumour-associated immune cells, focussing on macrophages, and their possible interactions with endothelial cells, and how this might impact the evolving mesothelioma TME in elderly people.
Towards healthier dining environments: evaluating indoor air quality in Dubai restaurants
Authors: Biju Priji , Sheta Wael , Saumer Bashaer
Published: November 2024

This study investigates the indoor air quality (IAQ) of restaurants in Dubai with a focus on the impact of cooking-related pollutants on the health and comfort of both employees and patrons. Recognizing the release of particulate matter (PM), carbon oxides, and volatile organic compounds (VOCs) during cooking, the study highlights the importance of maintaining healthy IAQ in restaurants. The study includes a detailed case analysis, evaluating current air quality standards, identifying potential pollutants, and assessing their implications. A preliminary assessment, combined with a quantitative inspection of the kitchen and dining areas, set the foundation for a survey conducted among staff and customers. This survey identified key areas of concern and the variables essential for monitoring to maintain IAQ at optimal levels. The study measured parameters such as PM2.5, PM10, temperature, humidity, interior lighting, CO, and total VOCs using appropriate instruments. Results indicated that cooking activities contribute to elevated levels of particulate matter, suggesting a need for enhanced ventilation or air purification systems to ensure a healthy working environment. While some employees reported discomfort during working hours, customer feedback was largely positive, with around 90% expressing satisfaction with the restaurant's IAQ. The findings underscore the importance of continuous monitoring and improvement of IAQ in the hospitality industry to safeguard the well-being of both staff and patrons.
Pengembangan Potensi Pariwisata dan Pemberdayaan UMKM di Kelurahan Teritip Kota Balikpapan
Authors: Fitria Irma , Salsabila Alfiyyah , Ardenta Yuda Raja , Wanta Firlanda Italis , Zulaikah Eny Lailatul , Jannah Wardatul , Hoan Richard Owen , Erliana Erliana , Alfianto Ahmad , Herliansyah Riki , Abdallah Bayu Nur
Published: November 2024

Pengembangan potensi pariwisata dan pemberdayaan UMKM menjadi strategi penting untuk mendorong pertumbuhan ekonomi lokal. Kelurahan Teritip, dengan keindahan alam, memiliki potensi wisata yang belum sepenuhnya terekspos. Melalui kolaborasi dengan mahasiswa, kegiatan pengabdian masyarakat dijalankan untuk mempromosikan potensi wisata dan mendukung UMKM dalam mengadopsi sistem manajemen yang efisien. Program mencakup pembuatan konten branding, pemasangan papan penunjuk jalan wisata, dan pembangunan sistem manajemen UMKM. Hasil kegiatan menunjukkan bahwa semua program telah dilaksanakan sesuai dengan rencana dan harapan mitra. Peningkatan daya tarik wisata di Kelurahan Teritip diharapkan dapat meningkatkan kualitas perekonomian wilayah sekitar dan produktivitas UMKM, memberikan peluang agar UMKM fokus pada pertumbuhan bisnis dan inovasi.
Unraveling the Roots: Investigating Etiological Patterns of Acute Kidney Injury in Hospitalized Patients at Khyber Teaching Hospital, Peshawar, Pakistan
Authors: Raza Ali , Suhail Samra , Noman Muhammad , Nisa Ulfat , Khattak Aaliyan , Banaras Faizan
Published: November 2024

Background
Acute kidney injury (AKI) is the main cause of poor outcomes for patients. AKI affects about 13.3 million individuals worldwide annually with eight-five percent living in nations that are developing.

Methodology
It was a cross-sectional study. 74 patients were included in the study. AKI was diagnosed using the RIFLE criteria, based on serum creatinine levels. Hospital acquired acute kidney injury (HAAKI) was defined as the onset of AKI occurring any time after 48 hours of hospitalization in patients who were admitted with normal renal function. Data was collected from patient records, such as demographics, and clinical history. Variables were reported as mean ± SD. Statistical calculation was done using Chi‐square test. P < 0.05 was considered significant. All the calculations were carried out with the help of software IBM SPSS STATISTICS 25 version.

Results
This study underscores the impact of HAAKI on patient outcomes, affecting all age groups, with a majority of cases among individuals under 50. The findings highlight infections and trauma, notably sepsis and hypotension, as major causes, making up over two-thirds of HAAKI cases. The severity of kidney injury, classified by the RIFLE criteria, was directly correlated with increased mortality and the need for dialysis, especially for patients in the "Failure" category. Survival outcomes were notably higher for those in the "Risk" stage compared to the "Injury" and "Failure" stages, which experienced higher mortality. This emphasizes the necessity for early detection and management of patients with progressing kidney injury to prevent progression to critical stages. Timely intervention could potentially reduce mortality and improve overall outcomes for HAAKI patients.

Conclusion
This study highlights HAAKI has significant impact on patient outcomes, showing that sepsis and hypotension are major causes. Mortality risk escalates with RIFLE category severity, particularly in the “Failure” stage. Early identification and proactive management are essential to reduce progression, improve survival, and enhance patient outcomes in HAAKI cases.
Outcome of Ticagrelor Versus Clopidogrel in ACS Patients Undergoing PCI
Authors: Manan Abdul , Raza Mahzaib , Ijaz ul Haq Sajeela , Saleem Qaiser , Sofia Azka Momina , Anika Fizza
Published: November 2024

Objective: To compare the efficacy and safety of ticagrelor versus clopidogrel in reducing major adverse cardiovascular events (MACE) and managing bleeding risks in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) at Pakistan Atomic Energy Commission of Pakistan. Methodology: This prospective, randomized study included 400 ACS patients undergoing PCI from January 2023 to August 2024. Patients were divided into two groups, receiving either ticagrelor (n=200) or clopidogrel (n=200), with outcomes assessed at 30 days. The primary outcome was the occurrence of MACE, and secondary outcomes included minor bleeding events and stent thrombosis rates. Data were analyzed using chi-square tests to compare efficacy and safety between groups. Results: Ticagrelor showed a slightly lower rate of MACE (49%) compared to clopidogrel (55%), suggesting enhanced efficacy in reducing ischemic events. However, ticagrelor also had a higher incidence of minor bleeding events (56.5% vs. 47% in the clopidogrel group), underscoring the need for careful patient selection due to increased bleeding risks. Stent thrombosis rates did not differ significantly between the groups. Conclusion: Ticagrelor provides a beneficial alternative to clopidogrel for preventing ischemic events in ACS patients undergoing PCI. However, due to its higher bleeding risk, individualized patient assessment is crucial to optimizing outcomes. These findings contribute essential evidence to guide antiplatelet therapy in the Pakistani context.
DİJİTALLEŞEN İŞ SÜREÇLERİNİN MALİ İŞLER ÇALIŞANLARI ÜZERİNDEKİ ETKİLERİNİN BELİRLENMESİ: ENERJİ SEKTÖRÜ ARAŞTIRMASI
Authors: Taşdelen Merve
Published: November 2024

İşletmeler teknolojik gelişmeler ile birlikte iş uygulamaları, iş stratejileri, iş ilişkileri alanlarında köklü değişiklikler yaşamaktadır. Bu değişikliklere ayak uydurmak durumunda kalan birimlerin başında Mali İşler Departmanı gelmektedir. Mali işler departmanı çalışanlarının kullanmış olduğu birçok sistem ve modül bulunmaktadır. Bu araştırma ile mali işler çalışanlarının kullanmış olduğu sistem, program ve modüller üzerinde sağlanan dijitalleşme çalışmalarının çalışanlar üzerindeki etkilerini ve çalışanların dijitalleşme süreçleri hakkında görüşlerini tespit etmek amaçlanmıştır. Çalışmanın evreni enerji sektöründe faaliyet göstermekte olan tüm mali işler çalışanları iken örneklem olarak 12 mali işler çalışanı seçilmiştir. Araştırmada nitel araştırma yöntemlerinden biri olan mülakat yöntemi kullanılarak veriler toplanmış ve betimleyici analiz yöntemi ile analiz edilmiştir. Görüşmeler 12 katılımcı ile yüz yüze gerçekleştirilmiş ve elde edilen veriler 9 ana tema çerçevesinde değerlendirilmiştir. Araştırma sonuçlarına göre enerji şirketleri dijitalleşme süreçlerinde çalışanlarına gerekli imkânları sağlamaktadır. İş geliştirme süreçlerinin şirkete olan en önemli katkısı zaman tasarrufu ve maliyet avantajıdır. Çalışan için bakıldığında ise vizyon ve bakış açısı kattığı ve kariyer avantajı sağladığı sonuçlarına ulaşılmıştır. Çalışanlar iş geliştirme süreçlerinin mevcut iş planları ile birlikte yürütülmesinin zorluk yarattığını belirtmiş, ancak uzun vadede iş planlarını rahatlatması nedeni ile geliştirmelerin gerekli olduğu sonuçlarına ulaşılmıştır.
Postoperative Effect of Diabetes Among Pancreatic Calculi Patient Treated by Puestow Procedure A Study of 25 Cases
Authors: Rahman Anharur
Published: November 2024

Background: Pancreatic calculi, characterized by calcified deposits in the pancreatic duct, often coexist with diabetes mellitus, complicating clinical management. The Puestow procedure, a surgical intervention for pancreatic calculi, impacts diabetes outcomes, necessitating comprehensive exploration. Objective: Aimed to assess the postoperative effects of diabetes in pancreatic calculi patients undergoing the Puestow procedure. Methods: A cohort of 25 case was conducted at Central Hospital Ltd Dhanmondi Dhaka, Bangladesh, from 2022 to 2023, underwent meticulous analysis post-Puestow procedure. DM control, insulin requirements, postoperative complications, and surgical outcomes were systematically assessed. Percentage analysis was employed to quantify results. Results: Post-Puestow, 80% of patients exhibited improved DM control. Overall, 86.67% in the Puestow arm showed positive responses, with 26.67% achieving complete response and 60% partial response. Surgical outcomes indicated a shorter recovery time in the Puestow arm (49 days) compared to 142 days in the control arm, demonstrating better patient compliance. Statistical analysis revealed a significant correlation between diabetes status and postoperative outcomes (p < 0.05). Conclusions: The Puestow procedure demonstrated favorable postoperative effects on diabetes among pancreatic calculi patients. Improved DM control and reduced insulin requirements underscore its potential impact. Mild complications and a moderate recovery period emphasize the procedure's feasibility. Tailored postoperative care considering diabetes status enhances overall outcomes.
Prevalence of low back pain in post menopausal women in the peripheral community of Bangladesh
Authors: Tazri Sumia Ahmed
Published: November 2024

Background: Low back pain (LBP) is a widespread issue among postmenopausal women, significantly impacting quality of life, especially in rural and low-resource settings. Objective: This study aimed to determine the prevalence and associated risk factors of LBP in postmenopausal women aged 55 years and older in rural Bangladesh. Method: A six-month cross-sectional study, conducted from January 2023 to July 2023, included 1,000 postmenopausal women at the Gynae and Orthopedic outpatient departments of the 250-bed Sadar Hospital, Sirajganj, and North Bengal Medical College Hospital. Data were gathered through a semi-structured interview on demographics, lifestyle factors, and health status, with physical activity and self-perceived health categorized into low and high levels. Informed consent was obtained. Results: Among the 1,000 participants, 620 (62%) reported LBP. LBP prevalence was significantly higher in women with low physical activity (n = 456, 76%) compared to those with high activity levels (n = 164, 48%). Additionally, LBP was reported by 400 women (80%) with poor self-perceived health versus 220 women (45%) with good health status. A significant association was found between educational level and LBP prevalence: women with primary school education (n = 320, 68%) had a higher prevalence than those with SSC-level education (n = 200, 50%) and more than SSC-level education (n = 100, 40%). Socioeconomic status and age at menopause were also significant predictors (p < 0.05). Conclusions: LBP affects a majority of postmenopausal women in rural Bangladesh, with higher prevalence among those with lower physical activity, poorer health perceptions, and lower educational attainment. Targeted community interventions are essential to reduce LBP prevalence in this population.
Knowledge and Practice level regrading Prevention and Nutritional Management of Hepatitis B among Blood Donors in some Selected Territory Hospital of Dhaka City Bangladesh
Authors: Sarker Narayan
Published: November 2024

Infection with the hepatitis B virus (HBV) is a global problem. The World Health Organization (WHO) reports that 240 million people worldwide—or one in thirty—have a chronic HBV infection, accounting for around one-third of all entities who have ever contracted the virus. The knowledge and practices of blood donors with regard to HBV are not well understood. Thus, the purpose of the study was to evaluate blood donors' knowledge and practices concerning nutritional management in relation to HBV. Using a straightforward sample technique and semi-structured questionnaires, 120 blood donors participated in face-to-face interviews for the cross-sectional study. Using a straightforward sample technique and semi-structured questionnaires, 120 blood donors participated in face-to-face interviews for the cross-sectional study. The data was analyzed using a variety of statistical procedures, such as t-tests, Pearson Chi-square tests, and frequency distributions. The participants' average age was 34.5 years, with the majority being female (83%), and most being between the ages of 31 and 40 (50.0%). According to this study, 56.7% of retailers showed good practices regarding HBV, and 25.0% had strong knowledge. One-way ANOVA and the independent sample t-test showed that blood donors from rural areas knew considerably more about HBV [0.80 (0.79-0.82) versus 0.78 (0.77-0.79)]; p=0.001. Likewise, the [mean] practice score for females was 0.81 (0.77-0.85) as opposed to 0.70 (0.59-0.81); p=0.02. And Muslim nurses [p=0.035] [0.89(0.76-0.93) against 0.79(0.61-0.87)] faiths has significantly higher positive and good practice management compared to their counterparts.
Öksürük Şikayeti ile Gelip Ewing Sarkom Tanısı Alan Hasta
Authors: Gökalp Şeyda , Çağlar Hanife Tuğçe , Buyukavci Mustafa , Pekcan Sevgi
Published: November 2024

Ewing sarkomu, dünya çapında en sık görülen ikinci kemik sarkomudur. Tanı anında uzak metastazlara sık rastlanılır, en sık metastaz yeri akciğerlerdir ve en önemli prognostik faktör de tanı anındaki metastatik hastalığın varlığıdır. Ewing sarkomunun prognozu, sistemik kemoterapi ve multimodalite yaklaşımı ile son zamanlarda iyileşmiştir. Biz bu makalede sağ 12. kostadan köken almış ve plevra metastazı sonrası tanı almış olan, kemoterapi tedavisi sonrası yapılan görüntülemelerde kitle tamamen kaybolduğu için cerrahi rezeksiyona gerek duyulmayan bir Ewing Sarkomu olgusunu literatürde ender olarak görülmesi nedeniyle sunmak istedik.
Pengaruh Work Life Balance Dan Komitmen Karyawan Terhadap Kinerja Karyawan Siloka Tasikmalaya
Authors: Alrasyid Fahmi , Rahwana Kusuma Agdhi , Risana Dudu
Published: November 2024

This research aims to determine the influence of Work Life Balance and Employee Commitment on the Performance of Kopi Siloka Tasikmalaya Employees. The method used was quantitative with a research sample of 35 respondents. The data used are primary and secondary data. The analytical tool used in this research is multiple linear regression analysis using SPSS version 25. Based on the results of this research, it shows that Work Life Balance and Employee Commitment simultaneously have a positive and significant effect on Employee Performance. Work Life Balance partially has a significant effect on employee performance. Employee Commitment partially has a significant effect on Employee Performance.
Med kompass mot mestring – et didaktisk perspektiv på matematikkvansker
Authors: Dalvang Tone , Lunde Olav
Published: November 2024

Artikkelen belyser matematikkvansker som et sammensatt fenomen. Ulike årsaksforklaringer fremføres, der forfatterne legger hovedvekten på didaktiske forhold. En modell presenteres som et redskap til å samtale, drøfte og forstå matematikkvansker i et sosio-kulturelt perspektiv. Ulike forklaringer og forståelser veves sammen i lys av konteksten. Modellen er en syntese som bygger på forfatternes kjennskap til praksisfeltet og teoretiske antagelser om for eksempel betydning av virksomhet og praksisfellesskap for læring. Artikkelen drøfter hvordan modellen kan brukes i praktisk arbeid ut fra en didaktisk vinkling med vekt på at eleven mestrer matematikken.
A collective enquiry into critical aspects of teaching the concept of angles
Authors: Runesson Ulla
Published: November 2024

This paper describes an approach to teaching that enhances pupils’ learning in mathematics. The model described – Learning study – involves teachers and researchers cooperating in an iterative process, gathering data about teaching and pupils’ learning, analysing the data, planning and revising their teaching. A particular theoretical framework was used as a guiding principle when designing and analysing learning. The goal was to identify aspects critical for learning the angle concept. It is demonstrated how the teachers were able to identify the critical aspects and change the teaching in a way that promoted pupils’ learning. What these critical aspects may entail and what teachers and researchers can learn from a Learning study is discussed.
Design of a didactic situation – mathematical experiments in linear algebra
Authors: Pedersen Thomas Vils
Published: November 2024

We describe how we used Brousseau’s theories of didactic 1 situations and didactic engineering as a framework for the development of an exam project in a first year mathematics course at a life science university. The main learning goals of the project were to (re)discover eigenvalues and eigenvectors partly by studying the asymptotic behaviour of matrix models for population growth and to understand the role eigenvalues play in such models. Moreover, the students would gain experience with mathematical experiments with the use of computers and with drawing conclusions from such experiments.
Book review: Researching, teaching and the practice of mathematical modelling and applications
Authors: Stillman Gloria
Published: November 2024

Christopher Haines, Peter Galbraith, Werner Blum, and Sanowar Khan (Eds.) (2007), Modelling ICTMA12: Education, Engineering and Economics. Chichester, UK: Horwood Publishing. ISBN-13: 978-1-904275-20-6
Word problems in upper secondary algebra in Sweden over the years 1960–2000
Authors: Jakobsson-Åhl Teresia
Published: November 2024

This paper reports results from a study on school algebra at the upper secondary level. The study considered changes in the algebraic content as it was presented in mathematics textbooks in the second half of the twentieth century in Sweden. The paper describes the changes of word problems in terms of the way they are used for developing algebraic skills. It is shown in what ways the place of the problems, the context and the use of mathematical models changed in the period in question. The use of word problems is related to the curricular documents of the time and to different views on school algebra.
Does the research reported in mathematics education journals have any relevance for practicing l teachers?
Authors: Lester Jr Frank
Published: November 2024

This paper is a revised and abbreviated version of a paper presented by Frank Lester at the plenary session at the research presession of the annual meeting of the National Council of Teachers of Mathematics in San Diego on April 23, 1996. It is the result of numerous discussions among the author, Gudmundur Birgisson and Paul Kehle over a period of several months beginning in November, 1995. During that time Birgisson and Kehle were doctoral students in the Mathematics Education Program at Indiana University. It has also been presented at the annual conference of the National Association for Research on Teaching Mathematics and Science, Vaasa, Finland in 1998