bluuebunny/crossref_metadata_2025 huggingface dataset:
Use of geophysical methods for soil profile evaluation
Authors: Groves Paul , Cascante Giovanni , Dundas Dave , Chatterji P.K.
Published: September 2011

A geophysical investigation was performed to evaluate the effectiveness of three geophysical methods (electrical resistivity imaging (ERI), seismic refraction (SR), and multiple-channel analysis of surface waves (MASW)) for geotechnical site characterization in swamps and environmentally sensitive wetland areas. The geophysical test results were verified against the results from borehole and cone penetrometer test logs. The ERI results were best for determining the depth to the glacial till. However, the resolution of the ERI survey was not sufficient to accurately predict the upper lithologies. The electrode spacing (4 m) was instead selected to reliably predict the depth to the till, which in this case varied between 4.6 and 10.7 m. The SR results overestimated the depth to the till because of the presence of a stiffness reversal. The MASW results predicted the depth to the refusal till layer less accurately than the ERI method. However, this method was able to detect the three distinct layers above the till, even though the layer thicknesses were consistently underestimated. The complementary use of geophysical techniques was a successful approach in determining the main soil units and the depth to the competent layer (till) at the site. These methods can be used as a basis for further development to optimize a procedure to reduce the number of boreholes required for conventional site investigations in areas that are environmentally sensitive or where access is restricted.
Growth dynamics of black spruce in stands located between the 51st and 52nd parallels in the boreal forest of Quebec, Canada
Authors: Tremblay Marie-Josée , Rossi Sergio , Morin Hubert
Published: September 2011

Despite their ecological importance, the role and effects of insect outbreaks on stand dynamics of the northern boreal forests in North America have still to be demonstrated. The study was conducted between the 51st and 52nd parallels in Quebec, Canada, to identify mechanisms governing regeneration of high-latitude stands by investigating variations in growth of trees during stand development. Chronologies of tree-ring width and individual dynamics of growth in height and volume were assessed in black spruce ( Picea mariana (Mill.) B.S.P) of one even-aged and five uneven-aged stands. Uneven-aged stands contained trees up to 340 years old and representing almost every age class. Several growth reductions were observed that were synchronized between stands and were characterized by high amplitudes but different percentages of affected trees. These reductions were followed by marked growth releases. Even if the absence of nonhost species prevented the building of chronologies that could confirm the origin of growth reductions, the findings suggested that spruce budworm ( Archips fumiferana Clemens [syn.: Choristoneura fumiferana (Clemens)]) outbreaks contribute to the formation and maintenance of the uneven-aged structure of older black spruce stands at high latitudes.
Toward a definition of the range of variability of central European mixedFagus–Abies–Piceaforests: the nearly steady-state forest of Lom (Bosnia and Herzegovina)
Authors: Motta Renzo , Berretti Roberta , Castagneri Daniele , Dukić Vojislav , Garbarino Matteo , Govedar Zoran , Lingua Emanuele , Maunaga Zoran , Meloni Fabio
Published: September 2011

Knowledge on the range of variability of montane European forests is hampered by limited data on the natural disturbance regime and by the small size of old-growth remnants. We studied the mixed Fagus – Abies – Picea Lom forest reserve (55.8 ha) in Bosnia and Herzegovina at three different scales: a grid of 40 sampling points to describe the structural characteristics and their range of variability, three transects to analyse gap size and gap fraction, and a 1.1 ha permanent plot to reconstruct age structure and disturbance history. The forest is characterized by a high volume of living trees (763 m3·ha–1in the 55.8 ha core area and 1160 m3·ha–1in the permanent plot) and of coarse woody debris (327 and 383 m3·ha–1, respectively). The percentages of forest area in canopy and expanded gaps are 19% and 41%, respectively. The median canopy gap size is 76.9 m2and ranges from 11.1 to 708.0 m2. There are large (up to 120 cm diameter at breast height) and very old trees (441, 432, and 416 years for silver fir ( Abies alba Mill.), Norway spruce ( Picea abies (L.) Karst.), and European beech ( Fagus sylvatica L.), respectively). During the last three centuries, the disturbance patterns have been characterized by single-tree or small group mortality. In central Europe, this forest is at the end of a gradient from forests characterized by intermediate disturbances to those where very small-scale processes predominate.
TESTING NEW PHYSICS WITH NEUTRINOS AND LEPTOGENESIS
Authors: DI BARI PASQUALE
Published: September 2011

Latest developments in leptogenesis are reviewed with a particular emphasis on the possibilities to test models of new physics, embedding the seesaw mechanism, by combining the requirement of successful leptogenesis with the information from low energy neutrino experiments. In particular, we discuss the role played by light and heavy flavor effects in the determination of the final asymmetry and the attractive features of the N2-dominated scenario that is naturally realized within SO(10) models. We also discuss leptogenesis within discrete flavor symmetries models, supersymmetry and in the minimal two right-handed (RH) neutrino model.
OPTICAL BISTABILITY IN A NONLINEAR SOA-BASED FIBER RING RESONATOR
Authors: COSTANZO-CASO PABLO A. , JIN YIYE , GRANIERI SERGIO , SIAHMAKOUN AZAD
Published: September 2011

A novel optical inverted bistable switch based on a nonlinear fiber ring resonator (FRR) containing a semiconductor optical amplifier (SOA) has been analyzed and experimentally demonstrated. Optical bistability is obtained due to the transmission characteristics of the resonator and the SOA's gain characteristics. A complete theoretical analysis and supporting simulations are presented. A prototype is demonstrated using commercial optical components. Experimental results show switching performance with falling times lower than 10 ns.
HOLOGRAPHIC RECORDING IN CORONA CHARGED ACRYLAMIDE-BASED MFI-ZEOLITE PHOTOPOLYMER
Authors: YOVCHEVA T. , NAYDENOVA I. , SAINOV S. , TOAL V. , MINTOVA S.
Published: September 2011

The influence of corona charging on holographic recording in acrylamide-based photopolymer nanocomposite containing MFI zeolite nanoparticles has been studied. The holographic recording was carried out in two different geometries — transmission grating recording and total internal reflection grating recording. During the recording process, the layers were charged in a corona field. It was observed that independently of the corona polarity, in the case of transmission geometry of recording, the corona charging led to a decrease in the diffraction efficiency (DE) of the grating. In the case of the total internal reflection grating, the DE increased in the corona field presence.
NONLINEAR OPTICAL PROPERTIES OF NOVEL AND EFFECTIVE H-SHAPED CHROMOPHORES CONTAINING THREE PARALLEL AND NON-CONJUGATED D-π-A UNITS
Authors: ZHANG CHAO-ZHI , CAO HUI , GUO ZHAO-BING
Published: September 2011

H-shaped chromophores containing three parallel non-conjugated D-π-A units are effective chromophores with high hyperpolarizability and good optical transparency. The semi-empirical methods ZINDO, AM1, MNDO and PM3 were employed to study the effect of strength of acceptors and donors, and steric repulsion between substituents on static first hyperpolarizabilities (β0) and enhancements of β0 of the H-shaped chromophores. The results show that the H-shaped chromophore would exhibit the largest β0 and/or the largest enhancement of β0 of the chromophore when combination of a donor (D) and an acceptor (A) in a D-π-A unit is suitable.
Endogenous BMP-7 is a critical molecular determinant of the reversibility of obstruction-induced renal injuries
Authors: Manson Scott R. , Niederhoff Robert A. , Hruska Keith A. , Austin Paul F.
Published: September 2011

Although obstructive uropathies are frequently correctable through surgery, the potential for permanent renal injury remains even following the successful correction of obstructions. Little is known about the intrinsic mechanisms that determine the reversibility of renal injuries. We and others found that exogenous bone morphogenic protein 7 (BMP-7) inhibits the pathogenesis of renal injury. Here, we examine the role of endogenous BMP-7 in the outcome of renal recovery following the correction of obstructive uropathies using a reversible murine model of ureteral obstruction. The role of BMP-7 was determined by examining the regulation of BMP-7 during renal recovery and by treating with either BMP-7-neutralizing antibodies or exogenous BMP-7. While BMP-7 is upregulated following the correction of obstructions that lead to reversible renal injury, the upregulation of BMP-7 is diminished following the correction of prolonged obstructions that lead to irreversible renal injury. The activation of the BMP-7 pathway is required for several processes that contribute to renal recovery including the suppression of transforming growth factor-β-dependent profibrotic pathways, the restoration of renal architecture, and the resolution of fibrotic changes in the kidney. Importantly, the therapeutic restoration of BMP-7 enhances renal recovery following the correction of prolonged obstructions that typically lead to irreversible renal injury. Together, these findings show that, while BMP-7 plays a critical role in the repair of obstruction-induced renal injuries, the potential for renal recovery from prolonged obstruction is diminished, in part, due to the dysregulation of BMP-7. Accordingly, renal recovery from obstructive uropathies may be optimized through timely intervention and adjuvant approaches to restore BMP-7 activity.
Optogenetic regulation of leg movement in midstage chick embryos through peripheral nerve stimulation
Authors: Sharp Andrew A. , Fromherz Sylvia
Published: September 2011

Numerous disorders that affect proper development, including the structure and function of the nervous system, are associated with altered embryonic movement. Ongoing challenges are to understand in detail how embryonic movement is generated and to understand better the connection between proper movement and normal nervous system function. Controlled manipulation of embryonic limb movement and neuronal activity to assess short- and long-term outcomes can be difficult. Optogenetics is a powerful new approach to modulate neuronal activity in vivo. In this study, we have used an optogenetics approach to activate peripheral motor axons and thus alter leg motility in the embryonic chick. We used electroporation of a transposon-based expression system to produce ChIEF, a channelrhodopsin-2 variant, in the lumbosacral spinal cord of chick embryos. The transposon-based system allows for stable incorporation of transgenes into the genomic DNA of recipient cells. ChIEF protein is detectable within 24 h of electroporation, largely membrane-localized, and found throughout embryonic development in both central and peripheral processes. The optical clarity of thin embryonic tissue allows detailed innervation patterns of ChIEF-containing motor axons to be visualized in the living embryo in ovo, and pulses of blue light delivered to the thigh can elicit stereotyped flexures of the leg when the embryo is at rest. Continuous illumination can disrupt full extension of the leg during spontaneous movements. Therefore, our results establish an optogenetics approach to alter normal peripheral axon function and to probe the role of movement and neuronal activity in sensorimotor development throughout embryogenesis.
Comparison of Continuous versus Categorical Tumor Measurement–Based Metrics to Predict Overall Survival in Cancer Treatment Trials
Authors: An Ming-Wen , Mandrekar Sumithra J. , Branda Megan E. , Hillman Shauna L. , Adjei Alex A. , Pitot Henry C. , Goldberg Richard M. , Sargent Daniel J.
Published: September 2011

Purpose: The categorical definition of response assessed via the Response Evaluation Criteria in Solid Tumors has documented limitations. We sought to identify alternative metrics for tumor response that improve prediction of overall survival.

Experimental Design: Individual patient data from three North Central Cancer Treatment Group trials (N0026, n = 117; N9741, n = 1,109; and N9841, n = 332) were used. Continuous metrics of tumor size based on longitudinal tumor measurements were considered in addition to a trichotomized response [TriTR: response (complete or partial) vs. stable disease vs. progression). Cox proportional hazards models, adjusted for treatment arm and baseline tumor burden, were used to assess the impact of the metrics on subsequent overall survival, using a landmark analysis approach at 12, 16, and 24 weeks postbaseline. Model discrimination was evaluated by the concordance (c) index.

Results: The overall best response rates for the three trials were 26%, 45%, and 25%, respectively. Although nearly all metrics were statistically significantly associated with overall survival at the different landmark time points, the concordance indices (c-index) for the traditional response metrics ranged from 0.59 to 0.65; for the continuous metrics from 0.60 to 0.66; and for the TriTR metrics from 0.64 to 0.69. The c-indices for TriTR at 12 weeks were comparable with those at 16 and 24 weeks.

Conclusions: Continuous tumor measurement–based metrics provided no predictive improvement over traditional response–based metrics or TriTR; TriTR had better predictive ability than best TriTR or confirmed response. If confirmed, TriTR represents a promising endpoint for future phase II trials. Clin Cancer Res; 17(20); 6592–9. ©2011 AACR.
Aflibercept (VEGF Trap) in Inoperable Stage III or Stage IV Melanoma of Cutaneous or Uveal Origin
Authors: Tarhini Ahmad A. , Frankel Paul , Margolin Kim A. , Christensen Scott , Ruel Christopher , Shipe-Spotloe Janice , Gandara David R. , Chen Alice , Kirkwood John M.
Published: September 2011

Purpose: Aflibercept is a soluble decoy VEGF receptor and angiogenesis inhibitor with potent preclinical antitumor activity in melanoma. We conducted a multicenter phase II study in patients with inoperable stage III or IV melanoma and no prior chemotherapy.

Experimental Design: A two-stage design was adopted to evaluate 4-month progression-free survival rate (PFSR) and response rate. Aflibercept was given at 4 mg/kg intravenously every 2 weeks. Response was assessed every 8 weeks. First-stage accrual of 21 patients was specified and with an adequate 4-month PFSR accrual continued to a total of 41.

Results: Forty-one patients of ages 23 to 84 (median = 57) were enrolled. Thirty-nine had American Joint Committee on Cancer stage IV (5 M1a, 7 M1b, and 27 M1c) and 2 had inoperable stage IIIC (N3). Eastern Cooperative Oncology Group (ECOG) performance status was 0 (27 patients) or 1 (14 patients). Ten patients had primary uveal melanoma, 28 cutaneous, and 3 had unknown primaries. A median of 7 cycles were initiated (range: 1–56). Grade 3 and 4 toxicities included hypertension in 9 patients (22%) and proteinuria in 6 (15%). Among 40 patients evaluable for efficacy (those who initiated aflibercept), 3 (7.5%) had a confirmed partial response and 20 had progression-free survival of 4 months or above. The predicted 1-year survival rate derived from the Korn meta-analysis model is 36% (N = 39), whereas we observed a corresponding 56.4% survival rate at 1 year (95% CI, 43–74, P < 0.005). Median overall survival in this trial is 16.3 months (95% CI, 9.2 to not reached). We observed a significant association between severity of hypertension following aflibercept and survival improvement.

Conclusions: Aflibercept showed promising activity in patients with metastatic melanoma of cutaneous or uveal origin. Further evaluation of aflibercept as a single agent and in combination is warranted. Clin Cancer Res; 17(20); 6574–81. ©2011 AACR.
A Randomized Controlled Trial of Celecoxib to Prevent Recurrence of Nonmuscle-Invasive Bladder Cancer
Authors: Sabichi Anita L. , Lee J. Jack , Grossman H. Barton , Liu Suyu , Richmond Ellen , Czerniak Bogdan A. , De la Cerda Jorge , Eagle Craig , Viner Jaye L. , Palmer J. Lynn , Lerner Seth P.
Published: September 2011

Significant morbidity and expense result from frequent recurrences of nonmuscle-invasive bladder cancer (NMIBC) after standard treatment, and carcinoma in situ (Tis) is a poor prognostic factor. Predicated on observational and preclinical data strongly supporting cyclooxygenase-2 (COX-2) in the pathogenesis, and the activity of COX-2 inhibitors, in bladder cancer, we conducted a randomized, double-blind, placebo-controlled trial to determine whether celecoxib could reduce the time-to-recurrence (TTR) in NMIBC patients at high risk for recurrence. A total of 146 patients were randomized to celecoxib (200 mg) or placebo orally twice daily for at least 12 months. The average treatment duration was 1.25 years. Primary intent-to-treat analysis revealed celecoxib did not statistically significantly prolong TTR compared with placebo (P = 0.17, log rank) with a median follow-up of 2.49 years. The recurrence-free rate at 12 months with celecoxib was 88% (95% CI: 0.81–0.96) versus 78% (95% CI: 0.69–0.89) with placebo. After controlling for covariates with Cox regression analysis, recurrence rates did not differ between the two study arms (HR = 0.69; 95% CI: 0.37–1.29). However, celecoxib had a marginally significant effect on reducing metachronous recurrences (vs. placebo) with HR of 0.56 (95% CI: 0.3–1.06; P = 0.075). Celecoxib was well tolerated, with similar adverse events and quality-of-life in both arms. Our clinical trial results do not show a clinical benefit for celecoxib in preventing NMIBC recurrence but further investigation of COX-2 inhibitors in this setting is warranted. Cancer Prev Res; 4(10); 1580–9. ©2011 AACR.
Developmental Activation of the Proteolipid Protein Promoter Transgene in Neuronal and Oligodendroglial Cells of Neostriatum in Mice
Authors: Fulton Daniel , Paez Pablo , Spreur Vilma , Handley Vance , Colwell Christopher S. , Campagnoni Anthony , Fisher Robin
Published: September 2011

Prior studies suggest that non-canonical proteolipid protein (PLP) gene expression occurs during development in non-myelinating neurons as well as myelinating oligodendroglia in mammalian brain. To assess this possibility in neostriatum, a region of uncertain PLP gene expression in neurons, morphological and electrophysiological tools were used to determine phenotypes of cells with activation of a PLP promoter transgene during the early postnatal period in mice. PLP gene expression is evident in both neuronal and oligodendroglial phenotypes in developing neostriatum, a conclusion based on three novel observations: (1) An enhanced green fluorescent protein (EGFP) reporter of PLP promoter activation was localized in two distinct populations of cells, which exhibit collective, developmental differences of morphological and electrophysiological characteristics in accord with neuronal and oligodendroglial phenotypes of neostriatal cells found during the early postnatal period in both transgenic and wild-type mice. (2) The EGFP reporter of PLP promoter activation was appropriately positioned to serve as a regulator of PLP gene expression. It colocalized with native PLP proteins in both neuronal and oligodendroglial phenotypes; however, only soma-restricted PLP protein isoforms were found in the neuronal phenotype, while classic and soma-restricted PLP protein isoforms were found in the oligodendroglial phenotype. (3) As shown by EGFP reporter, PLP promoter activation was placed to regulate PLP gene expression in only one neuronal phenotype among the several that constitute neostriatum. It was localized in medium spiny neurons, but not large aspiny neurons. These outcomes have significant implications for the non-canonical functional roles of PLP gene expression in addition to myelinogenesis in mammalian brain, and are consistent with potentially independent pathologic loci in neurons during the course of human mutational disorders of PLP gene expression.
Integration of 3D Electroanatomic Maps and Magnetic Resonance Scar Characterization Into the Navigation System to Guide Ventricular Tachycardia Ablation
Authors: Andreu David , Berruezo Antonio , Ortiz-Pérez José T. , Silva Etelvino , Mont Lluis , Borràs Roger , de Caralt Teresa María , Perea Rosario Jesús , Fernández-Armenta Juan , Zeljko Hrvojka , Brugada Josep
Published: September 2011

Background—

Scar heterogeneity identified with contrast-enhanced cardiac magnetic resonance (CE-CMR) has been related to its arrhythmogenic potential by using different algorithms. The purpose of the study was to identify the algorithm that best fits with the electroanatomic voltage maps (EAM) to guide ventricular tachycardia (VT) ablation.

Methods and Results—

Three-dimensional scar reconstructions from preprocedural CE-CMR study at 3T were obtained and compared with EAMs of 10 ischemic patients submitted for a VT ablation. Three-dimensional scar reconstructions were created for the core (3D-CORE) and border zone (3D-BZ), applying cutoff values of 50%, 60%, and 70% of the maximum pixel signal intensity to discriminate between core and BZ. The left ventricular cavity from CE-CMR (3D-LV) was merged with the EAM, and the 3D-CORE and 3D-BZ were compared with the corresponding EAM areas defined with standard cutoff voltage values. The best match was obtained when a cutoff value of 60% of the maximum pixel signal intensity was used, both for core (
r
2
=0.827;
P
<0.001) and BZ (
r
2
=0.511;
P
=0.020), identifying 69% of conducting channels (CC) observed in the EAM. Matching improved when only the subendocardial half of the wall was segmented (CORE:
r
2
=0.808;
P
<0.001 and BZ:
r
2
=0.485;
P
=0.025), identifying 81% of CC. When comparing the location of each bipolar voltage intracardiac electrogram with respect to the 3D CE-CMR–derived structures, a Cohen κ coefficient of 0.70 was obtained.

Conclusions—

Scar characterization by means of high resolution CE-CMR resembles that of EAM and can be integrated into the CARTO system to guide VT ablation.
Characterization of Energy Flux Partitioning in Urban Environments: Links with Surface Seasonal Properties
Authors: Loridan Thomas , Grimmond C. S. B.
Published: September 2011

A better understanding of links between the properties of the urban environment and the exchange to the atmosphere is central to a wide range of applications. The numerous measurements of surface energy balance data in urban areas enable intercomparison of observed fluxes from distinct environments. This study analyzes a large database in two new ways. First, instead of normalizing fluxes using net all-wave radiation only the incoming radiative fluxes are used, to remove the surface attributes from the denominator. Second, because data are now available year-round, indices are developed to characterize the fraction of the surface (built; vegetation) actively engaged in energy exchanges. These account for shading patterns within city streets and seasonal changes in vegetation phenology; their impact on the partitioning of the incoming radiation is analyzed. Data from 19 sites in North America, Europe, Africa, and Asia (including 6-yr-long observation campaigns) are used to derive generalized surface–flux relations. The midday-period outgoing radiative fraction decreases with an increasing total active surface index, the stored energy fraction increases with an active built index, and the latent heat fraction increases with an active vegetated index. Parameterizations of these energy exchange ratios as a function of the surface indices [i.e., the Flux Ratio–Active Index Surface Exchange (FRAISE) scheme] are developed. These are used to define four urban zones that characterize energy partitioning on the basis of their active surface indices. An independent evaluation of FRAISE, using three additional sites from the Basel Urban Boundary Layer Experiment (BUBBLE), yields accurate predictions of the midday flux partitioning at each location.
Improved Sea Ice Shortwave Radiation Physics in CCSM4: The Impact of Melt Ponds and Aerosols on Arctic Sea Ice
Authors: Holland Marika M. , Bailey David A. , Briegleb Bruce P. , Light Bonnie , Hunke Elizabeth
Published: September 2011

The Community Climate System Model, version 4 has revisions across all components. For sea ice, the most notable improvements are the incorporation of a new shortwave radiative transfer scheme and the capabilities that this enables. This scheme uses inherent optical properties to define scattering and absorption characteristics of snow, ice, and included shortwave absorbers and explicitly allows for melt ponds and aerosols. The deposition and cycling of aerosols in sea ice is now included, and a new parameterization derives ponded water from the surface meltwater flux. Taken together, this provides a more sophisticated, accurate, and complete treatment of sea ice radiative transfer. In preindustrial CO2 simulations, the radiative impact of ponds and aerosols on Arctic sea ice is 1.1 W m−2 annually, with aerosols accounting for up to 8 W m−2 of enhanced June shortwave absorption in the Barents and Kara Seas and with ponds accounting for over 10 W m−2 in shelf regions in July. In double CO2 (2XCO2) simulations with the same aerosol deposition, ponds have a larger effect, whereas aerosol effects are reduced, thereby modifying the surface albedo feedback. Although the direct forcing is modest, because aerosols and ponds influence the albedo, the response is amplified. In simulations with no ponds or aerosols in sea ice, the Arctic ice is over 1 m thicker and retains more summer ice cover. Diagnosis of a twentieth-century simulation indicates an increased radiative forcing from aerosols and melt ponds, which could play a role in twentieth-century Arctic sea ice reductions. In contrast, ponds and aerosol deposition have little effect on Antarctic sea ice for all climates considered.
Impact of a Vertical Vorticity Constraint in Variational Dual-Doppler Wind Analysis: Tests with Real and Simulated Supercell Data
Authors: Potvin Corey K. , Shapiro Alan , Xue Ming
Published: September 2011

One of the greatest challenges to dual-Doppler retrieval of the vertical wind is the lack of low-level divergence information available to the mass conservation constraint. This study examines the impact of a vertical vorticity equation constraint on vertical velocity retrievals when radar observations are lacking near the ground. The analysis proceeds in a three-dimensional variational data assimilation (3DVAR) framework with the anelastic form of the vertical vorticity equation imposed along with traditional data, mass conservation, and smoothness constraints. The technique is tested using emulated radial wind observations of a supercell storm simulated by the Advanced Regional Prediction System (ARPS), as well as real dual-Doppler observations of a supercell storm that occurred in Oklahoma on 8 May 2003. Special attention is given to procedures to evaluate the vorticity tendency term, including spatially variable advection correction and estimation of the intrinsic evolution. Volume scan times ranging from 5 min, typical of operational radar networks, down to 30 s, achievable by rapid-scan mobile radars, are considered. The vorticity constraint substantially improves the vertical velocity retrievals in our experiments, particularly for volume scan times smaller than 2 min.
Guerrilla Insurgency as Organized Crime
Authors: Hough Phillip A.
Published: September 2011

The escalation of violence committed by the Revolutionary Armed Forces of Colombia (FARC) guerrillas against noncombatant civilians triggered a shift in the theoretical orientation of scholars who study Colombia’s political economy. While previous explanations emphasized the sociopolitical “grievances” underlying guerrilla activities, recent explanations emphasize the “greed” motive, including guerrilla involvement in Colombia’s illegal narcotics trade. In this article, the author posits an alternative explanation using Charles Tilly’s theories of state formation to explain FARC activities in Caquetá, Colombia. Drawing from a longitudinal data set that documents the war making, state making, extraction, and protection activities of the FARC between 1975 and 2007, in addition to historical sociological methods, the author finds that increases in FARC repression stem from the growing militarization and paramilitarization of the region, which pressured the FARC to extract resources from the local population in a way that no longer served that population’s legitimate protection interests.
“CAN WE FEED?” A Mnemonic to Merge Nutrition and Intensive Care Assessment of the Critically Ill Patient
Authors: Miller Keith R. , Kiraly Laszlo N. , Lowen Cynthia C. , Martindale Robert G. , McClave Stephen A.
Published: September 2011

As care of the critically ill patient grows more complex, so does the breadth of knowledge required of the intensivist to deliver quality service. Nutrition is one area of many where the complexity of care has grown and the opportunity for improving patient outcomes has become evident. The use of mnemonics has proven successful in compartmentalizing information that must be considered in complex decision‐making processes. The authors propose one such mnemonic, “CAN WE FEED?” to assist in the development and initiation of early enteral nutrition therapy in the intensive care unit (ICU). Critical illness severity (C), age (A), and nutrition risk screening (N) are considered when performing a baseline evaluation of the critically ill patient upon presentation to the ICU. Wait for resuscitation (W) is a key component in the care of most critically ill patients and is an important consideration prior to the initiation of feeding. Energy requirements (E) are determined using conventional weight‐based equations, indirect calorimetry, or combinations of both techniques. The more practical aspects of support that follow include formula selection (F), enteral access (E), efficacy (E), and the determination of tolerance (D). With careful consideration of these components through the use of the mnemonic “CAN WE FEED?” the intensivist can successfully implement a nutrition plan, and the clinical nutritionist can appreciate where nutrition therapy appropriately intervenes in the initial resuscitation and management of the critically ill patient.
Nutrition Therapy of the Severely Obese, Critically Ill Patient
Authors: McClave Stephen A. , Kushner Robert , Van Way Charles W. , Cave Matt , DeLegge Mark , Dibaise John , Dickerson Roland , Drover John , Frazier Thomas H. , Fujioka Ken , Gallagher Dympna , Hurt Ryan T. , Kaplan Lee , Kiraly Lazlo , Martindale Robert , McClain Craig , Ochoa Juan
Published: September 2011

This report compiles the conclusions and recommendations for nutrition therapy of the obese, critically ill patient derived by the group of experts participating in this workshop on obesity in critical care nutrition. The recommendations are based on consensus opinions of the group after review of the current literature. Obesity clearly adds to the complexity of nutrition therapy in the intensive care unit (ICU). Obesity alters the incidence and severity of comorbidities, tolerance of the prescribed regimen, and ultimately patient outcome through the course of hospitalization. Although the basic principles of critical care nutrition apply to the obese ICU patient, a high‐protein, hypocaloric regimen should be provided to reduce the fat mass, improve insulin sensitivity, and preserve lean body mass. The ideal enteral formula should have a low nonprotein calorie to nitrogen ratio and have a variety of pharmaconutrient agents added to modulate immune responses and reduce inflammation.
Quality‐of‐Life Outcomes in Transoral Robotic Surgery
Authors: Hurtuk Agnes M. , Marcinow Anna , Agrawal Amit , Old Matthew , Teknos Theodoros N. , Ozer Enver
Published: September 2011

Objective

To report long‐term, health‐related quality‐of‐life (HRQOL) outcomes in patients treated with transoral robotic surgery (TORS).

Study Design

Prospective, longitudinal, clinical study on functional and HRQOL outcomes in TORS.

Setting

University tertiary care facility.

Subjects and Methods

Patients who underwent TORS were asked to complete a Head and Neck Cancer Inventory before treatment and at 3 weeks and 3, 6, and 12 months postoperatively. Demographic, clinicopathological, and follow‐up data were collected.

Results

Sixty‐four patients who underwent TORS were enrolled. A total of 113 TORS procedures were performed. The mean follow‐up time was 16.3 ± 7.49 months. The HRQOL was assessed at 3 weeks and at 3, 6, and 12 months, with a response rate of 78%, 44%, 41%, and 28%, respectively. TORS was performed most frequently for squamous cell carcinoma (88%). There was a decrease from baseline in the speech, eating, aesthetic, social, and overall QOL domains immediately after treatment. At the 1‐year follow‐up, the HRQOL scores in the aesthetic, social, and overall QOL domains were in the high domain. Patients with malignant lesions had significantly lower postoperative HRQOL scores in the speech, eating, social, and overall QOL domains (P <. 05). Patients who underwent adjuvant radiation therapy or chemotherapy and radiation therapy had lower postoperative scores in the eating, social, and overall QOL domains (P <. 05).

Conclusion

The preliminary data show that patients who undergo TORS for malignancies and receive adjuvant therapy tend to have lower HRQOL outcomes. TORS is a promising, minimally invasive, endoscopic alternative surgical treatment of laryngopharyngeal tumors.
Shoulder Sport-Specific Impairments After Arthroscopic Bankart Repair
Authors: Stein Thomas , Linke Ralf Dieter , Buckup Johannes , Efe Turgay , von Eisenhart-Rothe Rudiger , Hoffmann Reinhard , Jäger Alwin , Welsch Frederic
Published: September 2011

Background: Reports of return to shoulder-dependent sport after surgical stabilization previously underestimated impairments, which were not reflected in the score systems used.

Hypothesis: Return to shoulder-dependent sport depends on the type of sport performed.

Study Design: Case series; Level of evidence, 4.

Methods: Forty-seven athletes (26.9 years of age at surgery) who underwent isolated arthroscopic Bankart repair were longitudinally monitored by shoulder-dependent sport-specific activity (Shoulder Sport Activity Score [SSAS]) and ability (Athletic Shoulder Outcome Scoring System [ASOSS]) scores and visual analog scales for reachieved proficiency level, sport-specific shoulder pain, and functional deficits. Data were assessed at 4 points of treatment: preoperatively, and postoperatively after 6, 16, and 32 months (P0-P3). Athletes were analyzed separately according to shoulder sport: noncollision/nonoverhead (G1), collision (G2), overhead (G3), and martial arts (G4).

Results: The G1 and G2 athletes had reachieved the preinjury sport activity and sport proficiency status and excellent ASOSS scores after 32 months (SSASG1 = 7.2, SSASG2 = 8.1, ASOSSG1 = 94.4, ASOSSG2 = 95.2), whereas G3 and G4 athletes remained at an inferior activity level (SSASG3 = 8.0, SSASG4 = 8.3) and proficiency level. The ASOSS documented a prolonged period of shoulder rehabilitation for G3 and G4 athletes to reach a good shoulder-dependent sport ability outcome after 32 months (ASOSSG3 = 89.0, ASOSSG4 = 93.1). All groups recorded persisting limitations in visual analog scales for sport-specific shoulder function and pain. The established scores (Rowe = 95.9, Walch-Duplay = 93.3, Constant = 94.0) did not reflect these sport-specific impairments. Athletes with 5 or more preoperative dislocations had significantly longer surgery-to-sport resumption intervals with a prolonged proficiency recovery.

Conclusion: The athletes’ shoulder stabilization resulted in a prolonged rehabilitation depending on the functional demand of the performed shoulder-dependent sport, as shown by the specific shoulder sport score systems.
Evaluation, research and demonstration in the social sciences
Authors: Wieviorka Michel
Published: September 2011

In the social sciences, evaluation sometimes approaches a form of ‘quantophrenia’, as Sorokin put it. The factors that justify it (rationalization, the control of the correct use of public funds) are rapidly confronted with criticism which exposes the bureaucratization of research and asks major questions: in our disciplines what do we mean by finding and demonstrating? Can our research subjects be further generalized and organized in a sphere of discussion which has global scope without running the risk of being hindered by short-term logics of evaluation?
L’Edition scientifique en SHS face au numérique et à Internet: Un enjeu pour la France
Authors: d’Iribarne Alain
Published: September 2011

The ongoing revolutions in the media and practices employed by both writing and reading, together with the development of digitalization and the growth in Internet applications present a profound challenge to the activities of all actors involved in traditional publishing, and this includes libraries. These revolutions have a particular impact on the Human and Social Sciences (HSS), which are thereby offered what were heretofore practically inaccessible social prospects. Hence the importance for researchers in the HSS – in particular in France – of the stakes presently playing out around the policies conducted in this area.
The linear model of innovation: Maurice Holland and the research cycle
Authors: Godin Benoît
Published: September 2011

In 1928, Maurice Holland, Director of the Engineering and Industrial Research Division at the US National Research Council, produced a paper on what he called the ‘research cycle’. He portrayed the development of modern industries as a series of sequential steps from basic research to commercialization of technological inventions. The present article documents the source or context of the research cycle, the arguments on which it relies, and the use to which it was put, namely persuading more industrialists to build research laboratories in order to accelerate the development of industry. It suggests that Holland turned a frequently heard but poorly formalized argument into a ‘theory’, paving the way for what came to be called ‘the linear model of innovation’.
Where is disciplinarity going? Meeting on the borderland
Authors: Marcovich Anne , Shinn Terry
Published: September 2011

This article analyzes the cognitive structures and dynamics of a form of scientific discipline that differs importantly both from the disciplinary format of the 19th-century university system, and from the profile proposed by much postmodern interdisciplinary (anti-disciplinary) discussion. This recent form of discipline, here termed the ‘new disciplinarity’, is a product of the increasing complexity of scientific knowledge and activity. The approach privileges cognition. It emphasizes the concepts of disciplinary referent, robust boundaries, ‘borderland’, combinatorials and projects. It suggests that the new disciplinarity is highly elastic and that it is a spawning-ground for new disciplines.
Can moral convictions motivate the advantaged to challenge social inequality?
Authors: van Zomeren Martijn , Postmes Tom , Spears Russell , Bettache Karim
Published: September 2011

This article examines whether and how moral convictions, defined as strong and absolute stances on moralized issues, motivate advantaged group members to challenge social inequality. Specifically, we propose that violations of moral convictions against social inequality motivate collective action against it by increasing identification with the victims of social inequality. Such identification links the current work with the Social Identity Model of Collective Action (SIMCA; Van Zomeren, Postmes, & Spears, 2008 , in press ), which predicts that individuals’ motivation to challenge social inequality requires a relevant social identity in which group-based anger and group efficacy beliefs motivate collective action. For the advantaged, moral convictions are therefore powerful motivators of collective action against social inequality. Two studies, conducted in the Netherlands and Hong Kong, replicated empirical support for this line of thought. We discuss the theoretical and practical implications of our findings for collective action among the advantaged.
Antiretroviral Therapy Initiation in France
Authors: Latthaphasavang Vatthanaphone , Bouldouyre Marie-Anne , Rachline Anne , Ponscarme Diane , Rozenbaum Willy , Mary Jean-Yves , Delaugerre Constance , Molina Jean-Michel
Published: September 2011

Objectives and Methods: Retrospective study of all patients who started antiretroviral therapy (ART) in 2007 in a single center in Paris, with baseline characteristics and 1-year outcome, to assess adherence to national guidelines. Results: We analyzed 118 patients. Time of ART initiation was in agreement with the guidelines for only 64 (54.2%) patients. Fifty patients (42%) started ART with AIDS or a CD4 count <200 cells/mm3. In all, 62 (52%) and 47 patients (40%) received a combination of 2 nucleoside analogues with efavirenz (EFV) and 1 ritonavir-boosted protease inhibitor (PI/r), respectively. Treatment regimens were in accordance with the guidelines for 114 patients (97%). At 1 year, 16 patients (13.5%) were lost to follow-up, only 5 (4.9%) experienced HIV disease progression or death, but 19 (18.6%) required hospitalization. Antiretroviral therapy was changed in 21 patients (21%). Ten patients (8.4%) experienced virologic failure. Conclusion: Antiretroviral therapy was in agreement with guidelines for the choice of combination but was often initiated too late.
Practices for teaching moral values in the early years: a call for a pedagogy of participation
Authors: Johansson Eva , Brownlee Jo , Cobb-Moore Charlotte , Boulton-Lewis Gillian , Walker Susan , Ailwood Joanne
Published: September 2011

Schools have long been seen as institutions for preparing children for life, both academically and as moral agents in society. In order to become capable, moral citizens, children need to be provided with opportunities to learn moral values. However, little is known about how teachers enact social and moral values programs in the classroom. The aim of this article is to investigate the practices that Australian early years teachers describe as important for teaching moral values. To investigate early years teachers’ understandings of moral pedagogy, 379 Australian teachers with experience teaching children in the early years were invited to participate in an online survey. This article focuses on responses provided to an open-ended question relating to teaching practices for moral values. The responses were analysed using an interpretive methodology. The results indicate that the most prominent approaches to teaching moral values described by this group of Australian early years teachers were engaging children in moral activities. This was closely followed by teaching practices for transmitting moral values. Engaging children in building meaning and participatory learning for moral values were least often described.
Aggression and violence exposure in adolescence and the role of school- based policy initiatives
Authors: Kennedy Anne
Published: September 2011

This article reports on an exploratory study into young people’s exposure to aggression and violence. It undertakes a collective examination of the domains occupied by young people and in doing so focuses on an area that has for the most part been overlooked by previous researchers in the UK. The analysis is based on the responses of 98 young people aged 13–16 from two secondary schools in the north-west of England. The main findings reveal that the young people’s exposure to violence as a bystander is a regular occurrence and that their communities were no more or less damaging than the schools they attended. Observations are also offered in relation to policy initiatives intended to promote pupil well-being and a more conducive learning environment within primary and secondary schools.
Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia
Authors: Shen Yang , Zhu Yong-Mei , Fan Xing , Shi Jing-Yi , Wang Qin-Rong , Yan Xiao-Jing , Gu Zhao-Hui , Wang Yan-Yan , Chen Bing , Jiang Chun-Lei , Yan Han , Chen Fei-Fei , Chen Hai-Min , Chen Zhu , Jin Jie , Chen Sai-Juan
Published: September 2011

To evaluate the prognostic value of genetic mutations for acute myeloid leukemia (AML) patients, we examined the gene status for both fusion products such as AML1 (CBFα)–ETO, CBFβ-MYH11, PML-RARα, and MLL rearrangement as a result of chromosomal translocations and mutations in genes including FLT3, C-KIT, N-RAS, NPM1, CEBPA, WT1, ASXL1, DNMT3A, MLL, IDH1, IDH2, and TET2 in 1185 AML patients. Clinical analysis was mainly carried out among 605 cases without recognizable karyotype abnormalities except for 11q23. Of these 605 patients, 452 (74.7%) were found to have at least 1 mutation, and the relationship of gene mutations with clinical outcome was investigated. We revealed a correlation pattern among NPM1, DNMT3A, FLT3, IDH1, IDH2, CEBPA, and TET2 mutations. Multivariate analysis identified DNMT3A and MLL mutations as independent factors predicting inferior overall survival (OS) and event-free survival (EFS), whereas biallelic CEBPA mutations or NPM1 mutations without DNMT3A mutations conferred a better OS and EFS in both the whole group and among younger patients < 60 years of age. The use of molecular markers allowed us to subdivide the series of 605 patients into distinct prognostic groups with potential clinical relevance.
Alteration of BIRC3 and multiple other NF-κB pathway genes in splenic marginal zone lymphoma
Authors: Rossi Davide , Deaglio Silvia , Dominguez-Sola David , Rasi Silvia , Vaisitti Tiziana , Agostinelli Claudio , Spina Valeria , Bruscaggin Alessio , Monti Sara , Cerri Michaela , Cresta Stefania , Fangazio Marco , Arcaini Luca , Lucioni Marco , Marasca Roberto , Thieblemont Catherine , Capello Daniela , Facchetti Fabio , Kwee Ivo , Pileri Stefano A. , Foà Robin , Bertoni Francesco , Dalla-Favera Riccardo , Pasqualucci Laura , Gaidano Gianluca
Published: September 2011

Splenic marginal zone lymphoma (SMZL) is one of the few B-cell lymphoma types that remain orphan of molecular lesions in cancer-related genes. Detection of active NF-κB signaling in 14 (58%) of 24 SMZLs prompted the investigation of NF-κB molecular alterations in 101 SMZLs. Mutations and copy number abnormalities of NF-κB genes occurred in 36 (36%) of 101 SMZLs and targeted both canonical (TNFAIP3 and IKBKB) and noncanonical (BIRC3, TRAF3, MAP3K14) NF-κB pathways. Most alterations were mutually exclusive, documenting the existence of multiple independent mechanisms affecting NF-κB in SMZL. BIRC3 inactivation in SMZL recurred because of somatic mutations that disrupted the same RING domain that in extranodal marginal zone lymphoma is removed by the t(11;18) translocation, which points to BIRC3 disruption as a common mechanism across marginal zone B-cell lymphomagenesis. Genetic lesions of NF-κB provide a molecular basis for the pathogenesis of more than 30% of SMZLs and offer a suitable target for NF-κB therapeutic approaches in this lymphoma.