bluuebunny/crossref_metadata_2025 huggingface dataset:
Sanitary assessment and technological indicators of goat milk
Authors: Sufyanova Liliya , Smolentsev Sergey , Holodova Lyudmila , Kislitsyna Nadezhda , Zagidullin Lenar , Khisamov Rifat , Zakirov Tagir , Gorshenina Kristina , Larina Yulia
Published: September 2023

Milk and dairy products are indispensable for the full development and functioning of the body. In recent years, the demand for goat’s milk has increased. It has long been considered a source of health, especially in relation to people suffering from allergic diseases (including cow milk protein), with metabolic disorders, digestive disorders, etc. That is why the problem of obtaining high-quality goat milk is relevant and practically significant. Over the past few decades, interest has grown in a variety of biologically active substances of natural origin for their use as components of the diet of farm animals. Unlike antibiotics, growth stimulants and other synthetic drugs, phytogenics can be used in healthy animals for most of the productive period, providing a positive result in terms of quantity and quality of products. Based on this, we studied for the first time the effect of the plant product of stevia processing on the veterinary and sanitary indicators of goat milk. An experimental group of goats received stevia pulp together with the main diet. During the experiment, we found positive dynamics associated with the productivity of the goats of the experimental group. The use of an experimental feed composition provided positive dynamics in terms of the main indicators characterizing the technological value of milk. Thus, based on the data obtained, it should be concluded that the use of stevia pulp in combination with the basic diet provides positive dynamics for technologically significant indicators of goat milk, as well as increases the productivity of animals and ensures the production of products with high veterinary and sanitary characteristics.
Change of seed productivity of spermodonorous bulls belonging to the Bushuev breed by seasons of the year
Authors: Allayarov Sherali , Dosmukhamedova Mukhayo
Published: September 2023

Genetic productivity, feeding and maintenance conditions, and intra-herd characteristics are only a few of the variables that have an impact on the productivity of the cattle business. For coordinating production, several elements are essential [1–5]. Yet, it is also crucial to take into account the importance of current cattle in various economic farm categories around the nation. Personal assistants’ and peasant farmers’ individual family farms are smaller, more numerous, dispersed, have fewer financial and economic resources, and are run differently from bigger agricultural operations. Various factors have an impact on the productivity of the livestock industry. These include genetic productivity, feeding and maintenance conditions, and factors that are present within a herd. These factors play a crucial role in the organization of livestock production. The research project focuses on the study of five breeding bulls of the Bushuev breed, which are maintained at the state enterprise “Uznaslchilik”, under the same conditions as five other breeding bulls of the same age (two years). According to the results, the spring season had a positive impact on the reproductive function of breeding bulls, resulting in an increase in the volume of ejaculates. This increase ranged from a minimum of 0.17 ml in Angus bulls to a maximum of 0.43 ml in Bushuev bulls, showing an increase of 105-116%.
External characteristics and live weight of fleshy and woolly sheep breed of Uzbekistan
Authors: Shayusupov Bobir , Shakirov Kakhramon
Published: September 2023

This article describes the beneficial economic characteristics-productivity, exterior characteristics and growth and development of offspring of fleshy-woolly sheep of Uzbekistan in different breeding periods. In terms of wool yield, fleshy-woolly ewes outperformed native breed ewes. In this case, the amount of wool at shearing is 1.26 kg (49.6%), the weight of wool after washing is 0.97 kg (67.8%), and the length of wool is 2.13 cm (19.2%) higher. Lambs obtained from ewes in the experimental groups were determined at birth, 30 days, and 3 months of age. Ewes inseminated early from September 1 to September 20 had higher live weight, body size and wool productivity than those inseminated later, from October 20 to November 10. At the same time, it made it possible to introduce artificial insemination of fleshy-woolly ewes with frozen seeds of rams belonging to the global semi-soft woolly gene pool in the meat-wool direction. The live weight of lambs obtained from them was higher by at birth - 0.4 kg (9.3%), at 10 days - 0.5 kg (6.8%) and at 3 months - 0.4 kg (1.3%) compared to the live weight of lambs obtained from natural insemination of fleshy-woolly ewes with rams.
Pilaf a significant concept of the culture of the uzbek people
Authors: Ishniyazova Shakhnoza , Mastura Egamova
Published: September 2023

This article has discussed pilaf as a significant concept of the culture of the Uzbek people, how to prepare pilaf, which is considered the Uzbek national dish, was also discussed. Also, in this small scientific study method of cooking pilaf in different directions in different regions of Uzbekistan was given. The sentences about the pilaf of the main characters of the masterpieces of Uzbek national literature are presented and explained. It should be noted that the concept of “pilaf” becomes an archetype and a precedent. We would like to emphasize that it was with pilaf, as a national complex, that people of different nationalities began to get acquainted with Turkestan or Uzbekistan.
Ecological and chemical characteristics of well water in the Tobolsk district, Tyumen region
Authors: Popova Elena
Published: September 2023

The paper presents the results of comprehensive research on wells in the Tobolsk District, Tyumen Region, Russia. The chemical composition of water consumed by the population was analyzed. Two indicators were found to exceed the limits established by hygienic standards: total ammonia (sum of free ammonia and ammonium ions) and total iron. The content of total ammonia in groundwater on the studied area is high, ranging from 2.01 to 2.58 (MAC = 1.5) mg/l. According to the tests, the water from most of the wells is ferruginous, since the MAC is exceeded in almost all water samples. The iron content varies from 0.12 to 1.25 (MAC = 0.3) mg/l. The water from the underground water supply generally meets hygienic requirements.
Transformation of primary myelofibrosis into acute myeloblastic leukemia: clinical case
Authors: Baidurin Serik , Bekenova Farida , Tkachev Viktor , Kurmangalieva Klara , Khussainova Gulbana , Omirtaeva Bakhytkul
Published: September 2023

Primary myelofibrosis (PMF) is a disease from the group of Ph–negative myeloproliferative tumors, which is characterized by bone marrow fibrosis, splenomegaly and extramedullary hematopoiesis. The mean life in PMF ranges from 7.6 to 10 years and varies widely depending on the appearance of additional mutations and a higher degree of malignancy. Most patients have an indolent flow, and in some patients with PMF, the disease progresses rapidly with the development of acute myeloblastic leukemia. The international stratification system DIPSS-plus allows predicting the occurrence time of the PMF blast transformation phase. The article presents a case of early PMF transformation into acute myeloblastic leukemia in a patient with a heterozygous mutation in the JAK2 gene and an intermediate risk-2 established according to the International Prognostic Scoring DIPSS-plus. The patient received standard cytoreductive therapy.
Efficacy of Pfizer vaccine on IL-12/IFN-γ pathway with related to COVID-19 infection
Authors: Surhan Ruaa Kareem , Darweesh Mayyada F.
Published: September 2023

Critical patients with pandemic COVID-19 have dysregulation in immune response, like cytokine storm, lymphopenia that led to increase mortality, vaccine is the only hope for controlling on this pandemic. However, this study design to evaluate effectiveness of Pfizer vaccine on serum level for IL-12/IFN-γ pathway with susceptibility to COVID-19. The current study included 160 participants whom separated into two groups for further analysis which included Covid-19 patients as unvaccinated and vaccinated attended from various hospitals in AL-Najaf provenance and some private clinics and healthy control groups as vaccinated and unvaccinated healthy subjects, blood samples were collected from all subjects during January - April 2022 to detect IL-12 and IFN-γ concentration by ELISA technique. Demographic study indicated the male patients was higher than female and the age distribution for unvaccinated and vaccinated were 41-50 years had the highest frequency which were 17(42.5%) and (35%) respectively. The present study observed that the concentration of INF-γ (pg/ml) were show serum level decrease with Covid-19 infection, so IFN-γ in unvaccinated lower than healthy group and higher than vaccinated patients, while IL-12(pg/ml) serum level increase with Covid-19 infection, so IL-12 in unvaccinated higher than healthy group and vaccinated patients
Genetic detection of folate pathway inhibitors and outer membrane porins genes among gentamicin-resistant klebsiella pneumoniae isolates
Authors: Shallal Faris Hanoon Ali , Tuwaij Nabil Salim Saaid
Published: September 2023

Infectious diseases are one of the leading causes of morbidity and mortality worldwide, and antibacterial resistance exacerbates the situation. So this study aimed to investigate genes responsible for folate inhibitor pathway antagonists and outer membrane protein genes among gentamicin-resistant K.pneumoniae isolates. The results showed that out of 481 specimens, 270 (56.13%) showed bacterial growth versus 211 (43.87%) showed no bacterial growth. According vitek-2 system recorded 94 isolates as K. pneumoniae. Data demonstrated that 42/94 (44.68%) K. pneumoniae isolates were resistant to gentamicin compared with 24/94(25.53%) and 28/94(29.78%) of isolates were intermediate and sensitive to this antibiotic respectively. Results of antibiotic susceptibility showed that the highest bacterial resistance was piperacillin 41/42 (97.7%). while netilmycin 16/42 (38%) had the least resistance. PCR amplification results showed that dfr-B, Dfr-G and Dfr-K were 13/42 (30.9%), 17/42 (40.4%) and 37/42 (88.0%)) respectively. While Dfr-A did not detect. Also PCR results showed that 39 (92.8%) and 32 (76.1%) of the isolates had Ompk35 and Ompk36 genes respectively.
Allergo-immunological characteristics of comorbid passage of allergic rhinitis in children
Authors: Mirrakhimova Maktuba , Saidkhonova Adiba , Kurbanova Dilbar , Shamsiyeva Eleonora
Published: September 2023

In this article, the clinical and immunological characteristics of the comorbid course of allergic rhinitis with bronchial asthma in children are highlighted. The study was conducted in the children’s allergology department of the multidisciplinary clinic of the Tashkent Medical Academy, 50 patients with allergic rhinitis and 100 patients with bronchial asthma were involved. They studied the characteristics of the disease according to clinical symptoms (runny nose, sneezing, rhinorrhea, nasal itching) and immunological (general immunoglobin E, A, M, G, specific IgE and skin scarification test).
Morphological aspects of hyalinomembrane disease of the newborn
Authors: Mirzabekova Ozoda , Dadabaeva Rano , Nuriddinova Feruza , Ruzieva Zebo , Kulkaraev Abdisalim , Eshmamatov Oybek
Published: September 2023

In this scientific study, morphological and morphometric indicators of hyaline membrane disease in premature infants were studied. The material was obtained from the results of clinical-anamnestic analysis of preterm infants at 22-37 weeks and lung tissue. The results show that the immaturity of lung tissue, circulatory disorders and damage to the alveolar and bronchial epithelium play an important role in the development of hyaline membrane disease in the lungs of premature infants. The results of morphometric studies showed that only 1/3 of the lungs of infants born at 22-27 weeks had air in the alveoli, the thickness of the alveolar interstitial tissue, the epithelium of the alveoli was relatively large, and the resulting hyaline membranes were composed of relatively thin fibers. At 28–32 and 33–37 weeks, the dying groups observed an expansion of the area occupied by airborne alveoli in the infant’s lungs, thinning of the interstitial tissue, and thickening of the hyaline membranes compared to the previous group.
Comprehensive assessment of risk factors for the birth of a newborn with a congenital heart defect
Authors: Nabieva Shokhista , Lim Vyacheslav , Abdullaev Diyorjon , Sirojiddinova Xiromon , Tuxtaeva Mashkhura , Ataeva Mukhiba
Published: September 2023

The study aimed to identify risk factors and assess their contribution to the formation of congenital heart defects in newborns. 374 newborn children were examined, who were divided into groups II: Group I consisted of 324 newborns with congenital heart disease, group II consisted of 50 newborns without congenital heart disease. To determine the significance of risk factors, a questionnaire was compiled with a codifier of 42 signs reflecting socio-hygienic, medical and biological factors, the presence of intrauterine infections and the mother’s medication intake during pregnancy and obstetric and gynaecological history. The questionnaire was filled out by the mothers of the examined newborns. The studies were conducted using: an epidemiological study of risk factors, an analysis of information content on relative risk – RR and the calculation of the odds ratio – OR. The results of the studies showed that the modifying risk factors for the development of congenital heart defects (CHD) in newborns are: the age of the mother over 35 years (OR 2.57), closely related (OR 4.69) and unregistered marriage (OR 4.48), the presence of CHD in the family (OR 7.70), severe anaemia (OR 3.65), acute upper respiratory tract infections during pregnancy (OR 3.98), herpetic viral infection (OR 48.8), taking antifungal drugs (OR 3.24), the presence of miscarriages (OR 8,11), the threat of termination (OR 5,12) and induced pregnancy (OR 5,68), severe toxicosis (OR 3,49), fetal hypoxia (OR 4.01) and stress during pregnancy (OR 7.50). Thus, when assessing the risk of developing congenital heart defects in newborns, the use of the modifying factors identified by us will allow planning methods of prevention in families at high risk of the disease.
Study of the effect of herbal preparations on immunogenetics and hematopoiesis in the experiment
Authors: Rasulov F. Kh. , Teshaboev A. M. , Rasulov U. M.
Published: September 2023

When creating an experimental radiation sickness in animals, the development of deep immunodeficiency is observed, which manifests itself in the inhibition of the production of antibodies to the thymus-dependent antigen EB. Introduction to animals with radiation sickness Ginger, Detoxioma, and Gulzar balm help to increase the immune mechanisms of antibody production. Plant preparations can increase thymus nucleated cells in irradiated mice. Ginger, Detoxioma, and Gulzar balm significantly increase the level of erythrocytes and leukocytes in the blood of irradiated animals.
Etiological factors of secretory and invasive diarrhea and measures to improve their treatment
Authors: Kadyrov T. X. , Sarimsakov M. I. , Maxmutov R. X. , Qalandarova M. X.
Published: September 2023

Acute intestinal infections (AII) remain one of the most important problems of children’s infectious pathology, as this disease is diagnosed with severe forms and the mortality remains in high rate. Among patients with acute intestinal infection, children account for 60-70%. Severe forms of the disease are still noted to lead to death in young children. In addition, in recent years, there has been an increase in acute intestinal infections, an increase in their clinical manifestations and a long-standing uneven trend. The severity of the disease often occurs due to the development of viral-bacterial and bacterial-bacterial Complex in young children. V.F. Uchaikina et al. According to (2004), the main criteria for diagnosis include the following forms: gastritis, enteritis, gastroenteritis, colitis, enterocolitis, gastroenterocolitis, distal colitis. In the initial period of the disease (until the results of laboratory tests are obtained), for the construction of rational etiotropic and pathogenetic-based therapy of the OII, it is necessary to first determine the pathological process(enteritis, colitis) by taking into account the severity of the disease (mild, moderate, severe). Even with the severe course of the disease in childhood, acute intestinal infections contribute to their formation, especially in children with a decrease in the health index, prone to other infectious and somatic diseases. About the role of OIC in the pathogenesis of chronic diseases of the digestive system, leading to overeating and decompensation of diseases of the gastrointestinal tract. At present, the etiological structure of the AII has changed. Now the leading role among them in the world is undoubtedly that 50-80% of AII in children belong to viruses. Currently, intestinal infections are associated with representatives of at least 8 different types of viral oylases: Reoviridae, Saliceviridae, Adenoviridae, Astroviridae, Picornoviridae, Cobovirus, Coronaviridae, ovoviridae, Picornaviridae agent. The etiology of viral diarrhea is similar in developed and developing countries. The spectrum of possible etiological agents of acute gastroenteritis continues to increase, since previously unknown viruses were detected in patients, but it is necessary to confirm their significance in this pathology. This article aims to study the etiotropic treatment measures aimed at inhibiting the development of acute intestinal infection bacteria or virus.
Pregnancy during a pandemic of coronavirus infection COVID-19 risks and effects on the unborn child
Authors: Mamatkulova Makhbuba , Rosibayeva Yorkinoy , Yulchieva Sailibar
Published: September 2023

Pregnancy is a special time that is full of excitement and hope in every woman’s life. But for expectant mothers, fear, anxiety, and uncertainty because of the current COVID-19 status will turn this happy time into a cloud. Pregnant women with Covid-19 are less tolerant of both the pregnancy itself and the coronavirus infection. By complicating each other, they increase the risk of maternal mortality by a significant amount. However, if a pregnant woman is infected with Covid-19, the risk of severe infection increases. Not least because during pregnancy, physiological changes occur in the expectant mother’s body that suppress the immune response - in order to prevent rejection of the fetus, which is “still a half-foreign implant.”
Study of discontinuation issues in the blood service
Authors: Saidov A. B. , Madolimov A. M. , Ibragimov M. N.
Published: September 2023

The article examines the issue of suspension from blood donation and discusses their causes in persons who applied to blood service institutions. It was revealed that for 3 years, on average, 13% of those who applied were not allowed to donate. Of the total ineligible, 10% were temporarily suspended from donating. The main part of them - 8% due to low hemoglobin levels.
Social and psychological state as a factor for determining pronosological health
Authors: Abdumananov A. A. , Eshonov R. M.
Published: September 2023

The article shows the development of a continuous functioning technology for remote automated monitoring of the socio-psychological state of the population to determine the prenosological level of individual health, which allows to optimize medical non-invasive mass screening of the population. The technologies and their implementation are shown to ensure functioning with the use of information and communication technologies, mobile communications, methods of automated remote exchange, accumulation, storage of information, as well as with the involvement of medical knowledge, mathematical models and algorithms for their data mining socio-psychological state population, development and implementation of preventive measures, which are effective mechanisms to ensure health of the healthy people’s.
The results of the use of thrombolytic therapy in acute myocardial infarction at the prehospital and hospital stage
Authors: Kattakhanova R. , Umirzakov O.
Published: September 2023

The aim of the study was study of the use of thrombolytic therapy (TLT) in patients with myocardial infarction (MI) with ST segment elevationat the prehospital and hospital stage. The study included 181 patients with ST elevation MI. Depending on the thrombolytic used, the patients were divided into two groups: patients treated with streptokinase were included in the 1st group (n=78); the 2nd group (n=51) included patients with MI with ST segment elevation, who did not undergo TLT due to late seeking medical help or the presence of contraindications. TLT was performed both at the prehospital stage and in a hospital setting. We analyzed the time before TLT, the clinical course of MI, mortality, and complications. The time from the onset of clinical symptoms was 2.70.22 hours. The high efficiency of these thrombolytics was established in 66% of patients. Mortality during TLT was 6.4–7.7%, without TLT - 24%. Carrying out TLT in the first 3 hours from the onset of a heart attack was accompanied by a decrease in mortality to 3.4%. Not a single case of intracranial hemorrhage and allergic reactions was recorded.± TLT with streptokinase in patients with MI with ST segment elevation on the ECG in real clinical practice was characterized by high efficiency, a decrease in hospital mortality, complications, and a low percentage of side effects.
Diet on hirudoterapy to increase therapeutic effectiveness in hypertanic diseases
Authors: Fattakhov N. , Tillyaxodjayeva G. , Akbarova M. , Nuriddinov A. , Sakkizboyev I.
Published: September 2023

This article describes the experience of using hirudotherapy with a special diet. Patients were divided into sex and age groups, the effect of such therapy was monitored.
Clinical features and results of treatment of patients with coronavirus infection complicated by interstitial pneumonia, as well as with concurrent diseases in the Fergana Region of the Republic of Uzbekistan
Authors: Saidakhmedov O. , Sidikov A. A. , Makhmudov N. I. , Rasulova H. A. , Saidakhmedov Z. I.
Published: September 2023

To analyze the clinical features and treatment results, as well as concomitant diseases in patients with coronavirus infection complicated by interstitial pneumonia in the Fergana region of the Republic of Uzbekistan.
Results of surgical treatment of destructive pancreatitis
Authors: Rayimov G. N. , Kholmukhamedov Zh. , Tillaboldiev A. R. , Dekhkonov Sh. Sh. , Kosimov Sh. Kh.
Published: September 2023

Based on a retrospective analysis of the methods of surgical correction of ¬various clinical and morphological forms of pancreatic necrosis, the best options for tactics and surgical techniques for this pathology are proposed.
Role of EBV infection in Type-1 Diabetic nephropathy pathogenesis with related to IL-12 level in patients
Authors: Hussein Doaa , Darweesh Mayyada
Published: September 2023

Type 1 Diabetic nephropathy (T1DN) is the leading cause of chronic kidney disease globally The primary risk factors for the development of DN are chronic hyperglycemia and excessive blood pressure. In general, microalbuminuria screening should be done yearly, beginning 5 years after diagnosis in type 1 diabetes. This study design to investigate The role of IL-12 in the diagnostic of T1DN, and evaluation the role of IL-12 in patients infected and non-infected with EBVNA IgG. A case-control study design on 70 participates which included 30 patients with T1DN collected from nephrology department in Al-sadder medical city in AL- Najaf, from October 2022 till end of February 2023 and 40 control groups divided into two types, first 20 apparently healthy and 20 nephropathy patients. Blood sample was collected from all participants to detected IL-12 serum level and EBNA1 IgG by enzyme linked immunosorbent assay (ELISA). All patients were diagnosis by nephrology specialist. The results showed a that serum IL-12 levels were significantly higher in type 1 diabetic nephropathy patients (27.65 ± 3.78 pg/ml) than in the control groups (12.32± 3.41 pg/ml; 1.89 ±0.47 pg/ml) respectively at (P= 0.0001). Also The level of IL-12 was significantly elevated in T1DN patients infected with EBNA1 IgG (33.84 ± 4.47) in compare to patients non infected with EBNA1 IgG (13.21 ± 4.36) at P 0.01. Serum levels of IL-12 were significantly increased in T1DN Iraqi patients and increased correlated with infection of EBNA1 IgG.
Detection of Epstein-Barr virus and Hashimoto’s autoimmune in patients with a thyroid disorder
Authors: AL-Rammahi Anware Abd Hashim Auda , AL-Khilkhali Huda Jameel Baker
Published: September 2023

Hypothyroidism’s most common cause is Hashimoto’s thyroiditis (HT). Because Epstein-Barr virus is a common pathogen that causes autoimmune diseases to be prevalent worldwide and because it stays in the body for the duration of life, which explains why autoimmune diseases have a chronic course and are frequently accompanied by symptomatic exacerbations, the aim of this research is to determine the relationship between Epstein-Barr virus (EBV) and Hashimoto’s autoimmune disease in patients with a thyroid disorder. 120 samples were collected from the governorate of Najaf (60 with thyroidectomy and 60 as controls) to identify the presence of EBV. The proportion of patients with EBV was 27 (45%) compared to the control group, which was all negative. This study detects the autoimmune disease (Hashimoto thyroiditis) in all 160 samples using the anti-thyroperoxidase (TPO) test, which yields a positive result in 40% of patients (24), a negative result in 60% (36), and a negative result in 100% (60) of control samples.
Effect nanoparticles zirconium on bacteria growth multidrug resistance pseudomonas aerginosa isolated from burns patients
Authors: Jasim Ali Kareem , Hussein Ahmed Aleiwi
Published: September 2023

A total of 153 samples (swabs) were taken from burned patients between the ages of 2 and 75, representing a variety of age groups and body regions. All samples were obtained from Baghdad’s government hospitals. Beginning in early September 2022 and ending in early January 2023, (48/153) isolates (31.37%) were identified as P. aeruginosa Testing for antibiotic susceptibility It was conducted using various antibiotic classes (8 antibiotics), which were assessed using the VITEK 2 compact system. The results revealed that P. aeruginosa isolates were resistant to ceftazidime and cefepime (100%) in the same rate, the resistance to Tobramycin and Ciprofloxacin was (77.08), and the maximum sensitivity to Colistin was )79.1) and resistance to imipenem, meropenem, and Levofloxacin was (52.08%), (79.18%), and (72.92%), respectively. In this study used zirconium nanoparticles for inhibition growth bacteria. The efficacy of the synthetic nanoparticles against P. aeruginosa was tested as five different concentrations (1,2.5,5,10 and 15) mg/ml were adopted, and concentrations of (5,10 and 15) mg/ml showed efficacy in inhibiting bacterial growth while (1 and 2.5) mg/ml was not given any effectiveness, the results of minimum inhibitory concentration was (5) mg\ml.
Complex compounds of mesalazine with cyclodextrins and the prospect of their application in the ulcer disease treatment
Authors: Borisova N. S. , Gimadieva A. R. , Zimin Yu. S. , Murzakova L. I.
Published: September 2023

Mesalazine is highly effective in the treatment of ulcerative colitis and Crohn’s disease. However, in view of the fact that this compound is easily absorbed in the upper small intestine and cannot reach the large intestine at a therapeutic concentration, it is relevant to enclose it in the cavity of cyclodextrins through the formation of inclusion complexes of the “guest–host” type. Mesalazine complexation with α-, β-, γ- cyclodextrins was studied by spectrophotometric method in aqueous solutions. We established that the composition of the resulting complexes is 1:1. In the temperature range 296 - 321 K, the stability constants are calculated, and the thermodynamic parameters of complex formation are determined. We developed a technique for the synthesis of complexes, and a prototype, and studied its antiulcer activity. The authors established that the complex of mesalazine with β- cyclodextrin has a more pronounced antiulcer activity compared to the original substances, and approximately the same action as the reference drug (Omez). However, the amount of mesalazine in the complex was only 12% wt., the remaining 88% wt. account for β- cyclodextrin. The results obtained indicate the possibility of complex formation between mesalazine and α-, β-, γ- cyclodextrins. The resulting complex compounds can become the basis of new anti-inflammatory and antiulcer drugs.
Warehouse logistics information system using RFID tags as an effective way of automating business processes
Authors: Polyakov Roman , Chekalina Victoria , Ivanov Nikita , Myslimov Danil , Rudik Evgeniy
Published: September 2023

This article presents an information system project based on warehouse logistics using RFID tags. RFID tags are the last word in automating business processes related to the identification of various items. Now this technology is becoming attractive and relevant. The main goals of creating an information system are as follows: reducing the time spent on searching for goods, through the use of modern technology of RFID tags; increase search quality, due to non-contact remote detection and recognition of goods; improving the efficiency of the organization, due to the formation of reporting and statistical information.
Brazing Polycrystalline Diamonds (PCDs) in Applications of Cutting Tools: A review
Authors: Kareem Hayder Jalil , AL-Roubaiy Ahmad O. , Omidvar Hamid
Published: September 2023

This article surveys all researches which have conducted on polycrystalline diamond (PCDs) cutting tools, with particular consideration to the characteristics and performance of diamond-metal interface. There has been a revolution in industry over the fifty years or so, due to the usage of diamond in numerous applications, because of the special properties of diamond, joining diamonds to various materials by brazing requires much more precision than traditional brazing. Diamond is frequently utilized in cutting tools and workpieces because of its great hardness and wear resistance. Copper base filler & nickel base filler are the two materials that are most frequently used as brazing fillers in diamond brazing. This review describes the properties of diamond, how it interacts with metals and alloys, how it wets them, what influences these interactions, and how practical aspects of diamond joining is. Additionally, an analysis is done on a number of new brazing alloys, including amorphous Ni-based brazing filler metals.
Investigation of Corrosion Resistance in Stainless Steel 316L Alloy of Energy Separator by Electroless Plating (Ni-Zn-P)
Authors: Alghazali Hassan Hadi Masallb , Alfatlawi Abdulraheem kadhim AbidAli
Published: September 2023

The corrosion and hardness resistance of Ni-P coating is well recognized. By adding Zn, the electrochemical and mechanical properties of these coatings can be improved. In the coating procedure, two distinct periods of 1-hour and 2-hours are used. To improve the surface qualities of coating specimens, heat treatment at 400oC for one hour is performed. X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive analysis (EDS) were used to analyze the deposits. The hardness values of the coated heat-treated samples exceeded 900HV when compared to the bare and as-plated samples. The Tafel extrapolation test is used to determine the voltage and corrosion current in a 3.5% NaCl solution in order to calculate the corrosion rate. Corrosion rates are reduced from 1.81 mpy in bare specimens to 0.0642 mpy in heat treated plated specimens.
Wire Arc Additive Manufacturing of Steel: Deposition Patterns Effect on Microstructure and Mechanical Properties
Authors: Al-Roubaiy Arzaq , Al-Shafaie Saad , Jilabi Abdul Sameea
Published: September 2023

Recently, Metal Inert Gas (MIG) -based weld deposition process is one of the deposition-based Additive Manufacturing (AM) processes. This technique has created considerable interest due to the advantages it offers of being able to produce fully functional, complex, dense metallic objects. The study mainly aims to investigate the influence of a variety of deposition patterns on the microstructure and the mechanical properties of steel materials built on a low alloy steel substrate by MIG process. Experiments were carried out using a semi-automated MIG welding to built the samples manufactured using five different deposition patterns (longitudinal, transverse, right network, oblique and oblique network). Microscopy generally showed coarse equiaxed grains in the lower regions, fine equiaxed grains in the middle regions and columnar grains in the upper regions. The maximum hardness was (201HV) for the sample built with the oblique pattern, while the minimum hardness was (170 HV) for the sample built longitudinally. The highest average tensile strength value was (480 MPa) for the sample built longitudinally. The fracture mode was significantly ductile.The lowest average tensile strength value was however (262.5 MPa) for the sample built transversely, and the fracture mode was brittle.
Altitude Control of UAV Quadrotor Using PID and Integral State Feedback
Authors: Ma’arif Alfian , Suwarno Iswanto , Nur’aini Etika , Raharja Nia Maharani
Published: September 2023

Applications of control techniques for stabilizing altitude in a UAV Quadrotor, along with a comprehensive performance comparison, are presented in this paper. The two compared control techniques are: a Proportional Integral Derivative (PID) and Integral State Feedback (ISF) controller. While PID control consists of a Proportional, an Integral and a Derivative Controller, the Integral State Feedback consists of an Integral and a State Feedback Controller. Each part of the control technique provides advantages and drawbacks in the controlled system performance. Numerical simulations in the research were performed on Simulink MATLAB to provide quantitative results in control performance comparison; thus, a quadrotor model was designed prior to the application of control techniques. Based on the numerical results, ISF control resulted in a better settling time with zero overshoot than PID. Meanwhile, the PID control had a better rise time with a big overshoot than ISF in its system response. Therefore, it can be concluded that the ISF Controller was better than PID regarding the settling time and the overshoot response.
Application and development of IT technologies in Russian education: problems and solutions
Authors: Vorobyev Sergey , Ivliev Pavel , Ananyeva Ekaterina , Bakunin Sergey
Published: September 2023

Lately the role of information technology in education has grown significantly. One of the most important reasons for the use of information and communication technologies in the education system is undoubtedly a global tendency, which finds its expression in a huge number of online courses, trainings, individual consultations, applied through the use of various technical devices, which have become usual and quite common phenomenon in recent two or three decades. Another important reason for the transition to the online education system is associated with the COVID pandemic, since it is very logical to use online technologies for studies to prevent increased infection rates. It should also be noted that, in addition to the above obvious reasons for the use of information technology in the field of education, it is necessary to include such as the inability of the student to attend the teacher, or if the student does not want to attend an educational institution full-time for any reason, it can also be any psychological complexes of being in a large classroom, or lack of discipline in the student. All of the above strongly pushes and warms up society to the introduction and use of online technologies in education. This work is devoted to the study of the development and formation of information and communication technologies in the Russian education system, as well as the detailed analysis and discussion of the problems of the implementation and application of IT in Russia and ways of solving various kinds of problems arising in this area.
Criminal liability for violation of environmental protection
Authors: Zakharova Svetlana , Kilimbaev Roman , Korobkin Aleksey , Zharko Natalya
Published: September 2023

In the Russian Federation, industrial civil construction is currently one of the leading places in economic activity. It is one of the major factors of negative impact on the environment. At the construction stage, the most significant negative impacts on the environment are: air pollution by gas and dust emissions; pollution of underground and waste waters; pollution of the environment by construction waste; violation of the natural landscape of the area. One of the means of responding to violations of the rules of environmental protection and encroachment on environmental safety in the course of construction is the application of criminal law measures against subjects of socially dangerous behaviorIn the process of the study, the following legislative problems of regulating environmental crimes were identified: 1) the blanket nature of legal norms providing for liability for their commission; 2) the widespread use of evaluative concepts in characterizing the elements of an environmental crime; 3) the continuing nature of the acts in question; 4) features of the subject of environmental crime. These problems, to one degree or another, reduce the effectiveness of the criminal law impact on those responsible for committing environmental crimes in the construction industry. Based on the results of the study, a proposal was made to improve the norms of criminal legislation providing for liability for environmental crimes that violate the rules of environmental protection. It is proposed to provide for liability for violation of the requirements of environmental expertise. In addition, cases of applying the institute of reasonable risk in construction activities, which is a circumstance precluding the criminality of the act, are highlighted.
Insecta Orthoptera: a bibliometric review of papers from the Scopus database published in English for the period of 1986-2021
Authors: Izbasarova Zamira , Khalillaev Sherzod
Published: September 2023

Today, climate change, an increase in anthropogenic factors, and changes in the natural environment have an adverse effect on insect diversity due to the changing climes around the world. There has been an increase in the number of pests of agricultural crops over the past few years because of the expansion of the cultivated areas in arid regions, including the number of insects of the Order Orthoptera. The formation of fauna in different regions of the globe needs to be identified in order to improve the methods of combating them, and therefore, it is necessary to identify their formation. A great deal of research on the class of insects has been conducted over the last 35 years, and most of those articles are published in English. However, the research work on Insecta: Orthoptera was carried out in different topics and ways during those 35 years. The scope of this article is to cover all articles that have been published about orthoptera between 1986 and 2021 in the Scopus database. Various categories were analyzed in order to determine the quality of this research, including the year of research, who was responsible for the research, and which of the major research institutes did the research. In the light of the analysis, it is possible to have a certain understanding of the current research problems that are being experienced in this area as a result of the analysis.
Formation and development of petrochemical production in kazakhstan according to the cluster principle
Authors: Orazbayeva Kulman , Sadu Zhanna , Nurgaliyeva Zhanna , Akisheva Aruana , Ussenbayev Temirbek
Published: September 2023

The issues of the petrochemical industry development of the Republic of Kazakhstan by creating a petrochemical cluster in the western oil and gas region of the country are studied. The issues of creating a petrochemical cluster in Kazakhstan and creating an integrated petrochemical complex in the Atyrau region are considered. The essence of the cluster approach as the main factor in increasing the regional competitiveness of the Atyrau region is revealed, and the expediency and efficiency of creating a petrochemical cluster and an integrated petrochemical complex are substantiated. The stages of construction of an integrated petrochemical complex are described depending on the sources of supply of raw materials used. A schematic diagram of the formation of a petrochemical cluster in Kazakhstan is created. The main groups of factors substantiating the possibilities and economic expediency of creating a petrochemical cluster, which ensures the high profitability of this industry, are determined. It is shown that the innovative petrochemical cluster makes it possible to accelerate the diversification of the economy and the activation of non-primary, high-tech industries.
Influence of the innovative environment on the activation of enterprises in free economic zones
Authors: Maxsudov Sherzod , Tursunov Ozodbek , Baltabayeva Malokhat , Akhmadaliyeva Mokhigul , Rakhimova Kizlarxon
Published: September 2023

This article told, that the innovative potential of free economic zones, the level of efficiency in managing the attractiveness of the investment environment, the use of a rating system based on indicators of investment activity and the profitability of attracted investments, makes it possible to determine strategic management tasks aimed at increasing innovative and investment opportunities. In this article improve the efficiency of state regulation of Free Economic Zones and make managerial decisions to change the conditions for the manifestation of their activities, it is necessary to comprehensively assess the activities of Free Economic Zones using a single integral criterion. In improving the efficiency of free economic zones, it is important to accelerate the increase in the scale of the main activities of residents operating in the Free Economic Zones. Innovative activity is based on universal legality and objectivity. Environmental innovation-the creation of a specific environment and quantitative quality can be subjective. The enterprise strives for micro and macro environments that are considered important. Environmental exploitation: product, functionality, resource, control organization. An innovative organization engaged in the supply of products, functionality, resource, omillary organization. Innovative economy formation of conditions innovation activity, innovation makoning essentialist, Samara plant flourishing zharaenlarish ochib beradi.
Developing technical thinking of students in the process of preparation for professional activity
Authors: Ismailova Z. , Ashurova S. , Nasimova Z. , Sultanov A. , Shukurova O. , Norqobilov M.
Published: September 2023

The article analyzes the scientific ideas of technical thinking and determines its role and importance in the professional activity of the engineer, analyzes the state of the problem of developing students’ technical thinking in psychological and pedagogical theory and practice in higher education, specializes in the development of technical thinking generalization and systematization in accordance with the quality characteristics, as well as the development of technical thinking of engineering students and the development of a mechanism for its implementation.
Mechanism for designing the content of the professional competence of teachers in higher education institutions
Authors: Ismailova Z.K. , Jamoldinovna O. , Mukimov B. , Ruzibaev O. , Juraeva G.
Published: September 2023

In the article, the article in the article on the development of modern approaches, and leading and leading factors in the context of the development of vocational competitors of higher education institutions, the professional competence of heads and internal training, and the professional competence of the degree and agrological approaches The issues of improving the organizational and governance mechanisms of the development are covered and the development of the professional competence of the professional competence, and the practical introduction of didactic mechanisms based on innovative and interactive technologies.
Structural elements of didactic skills of educators in the educational process: theoretical and methodological approaches and principles
Authors: Rasulova Nilufar , Mukhamedova Nigora , Djalilova Gulchehra , Kariyeva Manzura , Rajabova Nodira , Yarova Sevara
Published: September 2023

The point is that the activity of the educator, who carries out the training of prospective specialists in the field of education, special requirements are made in connection with the effective disclosure of the potential of the modern information learning environment in the process of formation of students’ professional skills. In the process of professional development of students, mutual cooperation in the field of education, as well as dynamic pace of development of pedagogical information teaching environment, the pedagogue views not only the application of effective technologies, but also the interaction in the field of Education.
Improvement of professional and pedagogical activity of students on the basis of an adaptive approach
Authors: Mukhamedova Nigora , Djalilova Gulchehra , Eshdavlatov Bakhridin , Mirdadaeva Dilfuza , Iskandarova Gulnoza , Tuychiev Khayrullo
Published: September 2023

The article focuses on the adaptive mechanism of pedagogical adaptation of students to higher education, as well as the identification and development of adaptive abilities of students. The development of an indepth scientific analysis of the conditions of adaptation of students to the educational process and their preparation for further activities on a systematic basis in this regard requires justification of its improvement from a scientific point of view.
Systematic use of mathematical concepts in professional training of students
Authors: Kuchkarov M. , Khakimov S. , Abdullaeva B.
Published: September 2023

The article provides the mathematical concepts in the process of vocational guidance of students in higher education, the specifics of teaching higher mathematics based on the characteristics of the educational direction. Today, the higher education system is characterized by the development of intellectual potential, independent thinking and decision-making, and the creation of new generations of science programs is important to achieve this goal.
Technologies of methodical improvement of professional competence in the process of medical education
Authors: Musurmanova A. , Kadirova M. , Iminahunova I.
Published: September 2023

This article deals with issues of medical education, deontology of future doctors, methods of developing professional competence in medical education, comparative analysis of methodological support, pedagogical categories, professional qualities of medical staff, semantic content of medical education, factors influencing the health process, the importance of pedagogy in medical education. The tasks of education, distance learning in the process of medical education, the analysis of experimental results of research results are presented.