bluuebunny/crossref_metadata_2025 huggingface dataset:
PERAN BRAND AWARENESS DALAM MEMEDIASI PENGARUH CELEBRITY ENDORSER TERHADAP PURCHASE INTENTION
Authors: Setiawan Ida Bagus Putu Asdhi , Aksari Ni Made Asti
Published: July 2020

The purpose of this study was to determine the role of brand awareness in mediating the effect of celebrity endorser towards purchase intention on Adidas Yeezy shoe products. This research was conducted in the Province of Bali with a sample of 60 respondents using non-probability sampling method with purposive sampling technique. Data was analysed using path analysis and Sobel test. Study result showed that celebrity endorser have a positive and significant effect on brand awareness and purchase intention; brand awareness have a positive and significant effect on purchase intention; and brand awareness can significantly mediate the influence of celebrity endorser on purchase intention. The result of this study indicates that good brand awareness and celebrity endorser can influence the purchase intention of Adidas Yeezy shoe products.

Keywords: celebrity endorser, brand awareness, purchase intention
APPLICATION OF Trichoderma spp. AND LIGNOHUMATE TO SUPPRESS A PATHOGEN OF CLUBROOT (Plasmodiophora brassicae WOR.) AND PROMOTE PLANT GROWTH OF CABBAGE
Authors: Suada I Ketut , Suwastika Anak Agung Ngurah Gede , Pradnyana I Kadek Ngestika , Shchegolkova Nataliya , Poloskin Rodion , Gladkov Oleg , Yakimenko Olga , Stepanov Aleksey
Published: July 2020

The high economic value of cabbage crop leads farmers to make various efforts to suppress the pathogen of club root which is detrimental to plants. Efforts that need to be put forward must be environmentally safe. One way that is environmentally friendly is to control a pathogen biologically using antagonistic microbes. Therefore, the use of microbes such as Trichoderma which has been widely studied is important because it was able to suppress clubroot incidence and stimulate plant growth as well. Meanwhile, the need for plant nutrients to maximize plant growth requires an input of organic materials such as lignohumate which preserve soil nutrients, improve soil structure and increase plant resistance to biotic and abiotic stresses. The previous study on this scheme found an effective indigenous Trichoderma to suppress clubroot, therefore it is used in the current study. The objective of this study was to find out a combination treatment of Trichoderma and lignohumate which can suppress clubroot and increase plant growth. This experiment used a Randomized Block Design with 2 factors and 3 replications. Trichoderma concentration consisted of 3 levels, namely 0 spores (control), 1x106 spores. 2x106 spores, and 3x106 spores per plant which were suspended in 150 ml of water. The lignohumate treatments were 0.01, 0.02, 0.05, 0.1, 0.5, 1.0, and 2%. The results showed that lignohumate treatment was interact with Trichoderma population number on disease incidence, total clubroot, root dry weight, but not to canopy dry weight. The most suitable combination of treatments was the Trichoderma population of 3x106 spores (15 g) in combination to lignohumate of 0.5%.  This combination resulted in the lowest disease incidence, the lowest total clubroot, root dry weight, and the highest canopy dry weight. The higher the lignohumate concentration up to 0.5%, the higher the number of microbes (fungi and bacteria) growth, howeverit decreased above the concentration of 0.5%.
APPLICATION OF GAHARU-C FORMULATION (ORGANIC AND INORGANIC) FERTILIZER ON AGARWOOD PLANT AT SPECIFIC LOCATION IN TABANAN REGENCY
Authors: Mega I Made , Supadma A.A. Nyoman
Published: July 2020

This study aim is to determine the effect of the application of Gaharu-C fertilizer formulation of sapwood formed on agarwood plants at three specific locations in Tabanan Regency. This research is a factorial experiment with basic CRD design (completely randomized design). The first factor is location specific consisting of 3 location namely: Pupuan Subdistrict (Pu), Penebel Subdistrict (Pnl), and District of East Selemadeg (Sl). The second factor was the treatment of the Gaharu-C formula fertilizer consisting of 2 ie: 0 (without fertilizer), and C (Gaharu-C fertilizer formulation: 100 g urea + 100 g SP-36 + 100 g KCl) + (7.5 kg compost ) + (75 g dolomite) per tree), each treatment replicated three times. Number of plants used as many as 18 trees. Parameters observed included increased stem diameter, sapwood color, weight of sapwood, resin content and soil chemical properties data. Data analysis used variance analysis and LCD test (?= 0.05). The results showed that specific-location factors had significant effect on increasing stem diameter. However, had no significant effect on the color of sapwood, sapwood weight and resin level of sapwood. The fertilizer factor of Gaharu-C formula has no significant effect on all parameters observed. The highest increase of stem diameter was obtained at Pupuan location (0.40 cm), followed by East Selemadeg (0.32 cm), and the lowest Penebel (0.15 cm). The weight of sapwood and the highest resin content was obtained at the Sl C treatment of 5.34 g and 6.43%. The best application of Gaharu-C fertilizer formulation is in East Selemadeg Subdistrict.
MOLECULAR IDENTIFICATION OF FUNGI THE CAUSAL AGENT OF STRAWBERRY WILT DISEASE IN BALI
Authors: Wirya Gusti Ngurah Alit Susanta , Gargita I Wayan Diksa , Sudiarta I Putu
Published: July 2020

The development of strawberry farming in Bali experiencing some obstacles that cause a decline in production, such as wilting disease. The disease was reported caused by the fungi base on morphological recognition.  There are two fungi were recognized caused the strawberry wilt disease in Bali, they are from genus Verticillium and Fusarium. More specific information about causal agent of wilt disease in strawberry especially in Bali is needed. The one accurate identification is done through the molecular approach by analyzing DNA that encode the ribosomal DNA (rDNA). The 18S rDNA, including the internal areas of transcribed spacers (ITS), ITS1 and ITS4 have been widely used in phylogenetic studies. The amplification results of this area produce bands in different sizes that can be used to identify fungal species. Based on that the identification of strawberry wilt disease using molecular analysis was conducted. The 542 bp of Internal Transcribed Spacer (ITS) DNA was successfully amplified using PCR with pairing primers ITS 1 (5-TCCGTAGGTGAACCTGCGG-3’), and ITS 4 (5’-TCCTCCGCTTATTGATATGC-3’). The sequences of three isolates were successfully obtained through sequencing. Homology levels were tested between sequences and showed that Candi Kuning sequence and Gobleg sequence had 95% similarity with sequence of Fusarium oxysporum NRRL 13307 (U34571) from America. While Pancasari sequence have 94% similarity with sequence of Fusarium oxysporum NRRL 13307 (U34571) from America. Candi Kuning, Gobleg, and Pancasari sequences had the same 86% with sequence of Fusarium oxysporum isolate C34-294 Brazil (KJ439088) and had 89% similarity with sequence Fusarium oxysporum f.sp. fragariae China (KT833080). Homology levels were tested between sequences and showed that Candi Kuning sequence and Gobleg sequence had 95% similarity with sequence of Fusarium oxysporum NRRL 13307 (U34571) from America. While Pancasari sequence have 94% similarity with sequence of Fusarium oxysporum NRRL 13307 (U34571) from America. Candi Kuning, Gobleg, and Pancasari sequences had the same 86% with sequence of Fusarium oxysporum isolate C34-294 Brazil (KJ439088) and had 89% similarity with sequence Fusarium oxysporum f.sp. fragariae China (KT833080). Based on phylogeny analysis of Pancasari, Gobleg and Candi Kuning isolates were obtained in one group with Fusarium oxysporum identified in America and Brazil, and also in one group with Fusarium oxysporum f. sp. fragariae that identified in China.
ANTIOXIDANT ACTIVITY OF THE TOPICAL PREPARATION OF BULUNG SANGU (Gracilaria spp) EXTRACT
Authors: Sasadara Maria Malida Vernandes , Wirawan I Gede Putu , Sritamin Made , Suada I Ketut , Adiartayasa Wayan
Published: July 2020

Bulung Sangu (Gracilaria spp) as many other macroalgae, is a source of beneficial phytochemical for health. Phytochemicals in macroalgae are widely used as active ingredients in cosmetic preparations. The study was aimed to determine the antioxidant properties of Bulung Sangu formulated in topical preparation. Bulung Sangu was macerated in ethanol 96% following by extract formulation in cream preparation in two concentrations: 5% and 10%. Antioxidant activity was determined against DPPH radical, compared to ascorbic acid. Percentage of reducing power in five concentration series (10, 20, 30, 40, and 50 µm/ml) statistical analyzes using one-way ANOVA with 95% of confidence level, following by IC50 measurement. Absorbance was read in wavelength of 517 nm. Concentration of 5% and 10% cream extract exhibited IC50 of 13,091 µg/ml and 11,867 µg/ml, respectively. These values are lower than IC50 of ascorbic acid (18,505 µg/ml), indicating the strong antioxidant properties of Bulung Sangu extract cream which is more potential than ascorbic acid. Bulung Sangu exhibit a potential source for being developed as medicine and cosmetics in topical preparation.
PRIMER DESIGN OF CVPDr DNA FRAGMENT SEQUENCES THAT AMPLIFY SPECIFIC FRAGMENTS TO DISTINCT THE RESISTANT FRAGMENT FROM Triphasia trifolia (Burm. F.) P. Wils. AND THE SUSCEPTIBLE FRAGMENT FROM Citrus nobilis Lour.
Authors: Utami Ni Made Ayuratih , Wirawan I Gede Putu , Suada I Ketut
Published: July 2020

CVPDr is a DNA fragment that indicates that plants are resistant to CVPD. Previous research using primers that amplified 841 bp CVPDr fragment was able to amplify the fragment from Triphasia trifolia that considers being a resistant plant, Citrus aurantifolia var. seedless which considers being a tolerant plant, and some susceptible citrus plants to CVPD disease. In this study, we designed some primers that amplified only CVPDr DNA fragment from T. trifolia which consider as the resistant plant and a primer that amplified only DNA fragmen from Citrus nobilis which consider as the susceptible citrus plants. The primers for CVPDr on T. trifolia are TCATCTGCATGGGATACC for forward primer and GCCTTGAGCTTGTAAGTG for reverse primer which turned out to amplify the DNA of T. trifolia and also the C. nobilis cultivar Denpasar and only succeeded in not amplifying the C. nobilis cultivar Gianyar. The primers for CVPDr on C. nobilis are GAATGGCTTAGCAGAAAGG for forward primer and GGTTGTAGATGGACATAGG for reverse primer turned out can not only amplify the DNA C. nobilis but also amplify T. trifolia.
PERBEDAAN SKOR WORK ENGAGEMENT GURU SMP NEGERI DI KECAMATAN DENPASAR UTARA PADA KELOMPOK MASA KERJA 1-4 TAHUN, 5-19 TAHUN, DAN LEBIH DARI 20 TAHUN
Authors: Indraswari Putu Gita , Adiputra I Nyoman
Published: July 2020

Work engagement is influenced by job demand, job resources, and personal resources. However, there are differences in the results of previous studies on the relationship oflength of service with work engagement. This study aims to prove the difference ofwork engagement score on junior high school teachers in North Denpasar with 1-4 year,5-19 year, and more than 20 year length of service.  It has been  implemented anobservational study with cross-sectional design, conducted at the Junior High School, 38located in North Denpasar District, include SMPN 2 Denpasar, SMPN 3 Denpasar, SMPN 4 Denpasar, SMPN 5 Denpasar, SMPN 10 Denpasar, and SMPN 12 Denpasar. Total subjects were used in this study were 147 people. Work engagement scores were calculated using Utretch Work Engagement Scale (UWES). The length of service is classified into 1-4 years, 5-19 years, and more than 20 years. Total Work EngagementScores were compared using Kruskal-Wallis test with a significance level of 0.05. Showed that there was an increase in mean scores significantly in group 1-4 yearslength of service with a mean of 79.66 ± 12.98 and group over 20 years with a mean score of 87.01 ± 7.99 (p <0.05 ). A significant result was also obtained in the group of5-19-year length of service with mean score 80.84 ± 8.75 and group with over 20 years with  a mean score of  87.01  ±  7.99.  However,  based on the  correlation  test, the association  between  engagement and length of service is not  a significant.  It was concluded that there was difference in mean scores significantly in group work periodof 1-4 years and group over 20 and also group of 5-19-year length of service with and group with over 20 years. So that should be efforts to improve work engagement in the group of teachers with of 1-4 years and 5-19 years length of service
PENGEMBANGAN KUESIONER UNTUK MENGEVALUASI USABILITAS E-LEARNING
Authors: Kiswandari Amalia , Dharmastiti Rini , Wijaya Andi Rahadiyan
Published: July 2020

Interface design of e-learning sometimes people see only as a choice, not the main point. But, the basic thing about interface is it the main tool that have function to give user direction about how is using e-learning because it covers all element in e-learning. Usability is the tool that can measure the effective interaction between user and interface to achieve specific purpose. Questionnaire is a tool that practical, efficient and the most using tool to evaluate the usability. But, there is not yet a specific questionnaire in Indonesia that can evaluate usability of e-learning in general.The purpose of this study is to develop a measuring tool which is questionnaire that can capture usability problems in e-learning, know the usability questions attributes that become themost influence on the evaluation of the usability case studies in e-learning, and evaluate the problem of usability in the case study with the questionnaires which have been developed. The object of this study is an e-learning developed by the University of Gadjah Mada, namely eLisa, Synthesis (Faculty of Economics and Business), Gamel (Faculty of Medicine), and Papyrus (Department of Electrical Engineering and Information Technology). A sample of 317 respondents.The results of this study are valid and reliable questionnaire, and obtained 14 usability dimensions with 56 variables question from factor analysis result. This questionnaire has the consistency and relevance with the problems that reflected in open-ended questions, covered views from the mean value of merit usability. The comparison of four e-learning is a consistent ratings between the average value of variable merit 56 questions on the contents of the variable 5 questions in the concluding section. The result of comparisons with other questionnaires showed that the questionnaire is more effective because it can cover 73.21% of the existing problems in a more specific eLisa and evaluate a problem of usability.This research can still be developed and refined from research object of e-learning are more general by a combination of respondents from several countries to prove the relationship of user characteristics in terms of preference, culture, and language affect the evaluation of each individual to the usabiltity of e-elarning.
HUBUNGAN KEMAMPUAN KERJA DAN ANGKA MANGKIR KERJA KARYAWAN HOTEL BINTANG TIGA BAGIAN HOUSEKEEPING DI DENPASAR
Authors: Prasetio Renaldi , Adiputra Nyoman
Published: July 2020

The work ability of employees and work absence is important in nowday's. These things need to be considered to achieve good service quality, especially the hotel employees at housekeeping department. Employees task at housekeeping department is very important, especially for the comfort and cleanliness of the hotel. The employees with good workability and low work absence will certainly improve the quality of service of the hotel. The purpose of the research was to find out the correlation between work ability and work absence among 3-star hotel employees at housekeeping department at Denpasar. This research was using a cross-sectional analytic study. The number of respondents were 31 people consisting of 3-star hotel employees at housekeeping department atDenpasar. The  respondents were asked to fill Work Ability Index and mention work absence in the past year. Tables are used to show the results of the study and analyzed using the Spearman correlation test.  The research showed that the average of work ability is 41.48, sickness absence and off work are 3.74 and 11.22. There was significant correlation between work ability andnumber of a sickness absence (p=0.006). While the work ability and number off work have no correlation (p=0.461). It can be concluded that work ability and sickness absence have a correlation but there was no correlation between work ability and off work among 3-star hotel employeesat housekeeping section.  It may suggest  to  implementing  regular training to improve employability in an effort to decrease sickness absence
Farmer Group Institution’s Typology and Agricultural Innovation Implementation Sustainability
Authors: Hilmiati Nurul
Published: July 2020

Farmer group institutions have been being a target group for various innovations in the agricultural development program. Unfortunately, the aspect of their institutional system is getting ignored frequently. This study aimed to know the farmer group institution performance’s determinant factors and its effect on the agricultural innovation implementation sustainability. This was a longitudinal study using a qualitative approach involving ten farmer group institutions (mixed crop-livestock farming) done in Lombok island. The study showed that farmer groups with a good institutional system relatively performed a high level of sustainable innovation implementation in comparison with the group with a poor institutional system. There were four key factors affected the performance and the farmer group institution’s achievement: (1) strong leadership; (2) transparency; (3) regular group meeting; (4) and cash generating factor. The study also showed that farmer group institution which didn’t have those key factors tended to use the farmer group institution only to complete their physical need (impounded cows for security reason). It rarely uses to empower its group members. These conditions slowly could be developed as an individualistic treat on each group member that prevents the sustainable innovation implementation in the future. The agricultural innovation on this type of group usually only implemented in a short amount of time. Therefore, guidance for a good institutional system in a farmer group institution is required to be conducted to achieve a sustainable and comprehensive agricultural innovation implementation. Some strategies could be used to develop the four key factors to form a good institutional system in the farmer group institution.
The Feasibility of Mango Farming Agribusiness in Oro Oro Ombo Wetan Village, Pasuruan Regency
Authors: Kusmaryatun Sri , Pudjiastuti Agnes Quartina , Prihatminingtyas Budi
Published: July 2020

Oro-Oro Ombo Wetan Village in Rembang District was an area that produce the highest mango commodity in Pasuruan Regency with a productivity level of 72.95 kg/tree in 2017. The high productivity level didn’t correlate positively with the income. This situation affected by the mango commodity price on the farmer level, investment cost, and production infrastructure cost. The mango production and price in this village relatively fluctuated. Therefore, it important to assess the feasibility and sensitivity of the mango farming agribusiness in this village. This study aimed to know the mango farming agribusiness feasibility in Oro Oro Ombo Wetan Village, Rembang District, Pasuruan Regency, and its sensitivity to the price and production volume change. The survey technique conducted to collect the data. The agribusiness farming feasibility analyzed in the interest level of 8% with the investment criteria of: gross B/C, net B/C, break-even point, payback period, NPV and IRR. The sensitivity analysis used to know the feasibility percentage when the price decrease as much as 10% and the mango production decrease as much as 20%. The result showed that the mango farming agribusiness in Oro-Oro Ombo Wetan village feasible to be conducted. This agribusiness was not sensitive to the decrease of the 10% price and 20% mango volume production.
The Development of Rice Field Area in Special Region of Yogyakarta
Authors: Pratiwa Siregar Abi , Oktaviana Nadia , Rahmantyo Tarsilohadi Edy
Published: July 2020

In general, the development of agricultural land usage change was illustrated through linear trend analysis without comparing it first with other trend analysis. As a consequence, it was assumed that the data will be in a straight line with a tendency for constant numbers over a period of time. However, the facts on the ground proved that the area of ??agricultural land converted into non-agricultural land was not always the same from year to year. The novelty of this research was to do a comparison between linear and non-linear trends to predict the development of rice fields, so that an accurate forecasting model was obtained. The aim of this research were: 1) knowing the development of rice fields area in the Special Region of Yogyakarta, 2) determining the appropriate forecasting model for the development of rice fields area in the Special Region of Yogyakarta, and 3) forecasting the area of ??rice fields in the Special Region of Yogyakarta. The data that used came from BPS (Central Bureau of Statistics) from 1996 to 2017. The trend models being compared were linear trends, quadratic trends, and exponential trends. The results showed that the area of ??rice fields in the Special Region of Yogyakarta tended to decrease from year to year. The best forecasting model was an exponential trend. In 2017 to 2021, it was estimated that there will be a decrease in rice field area of ??221 hectares or 0.41 percent per year.
Explanation and Analysis of Localization Approaches of Academic Humanities Curriculum From the perspective of Iranian Education
Authors: Esfandiyari Yadolah , Nourabadi Soolmaz
Published: July 2020

In recent years, the evolution of education and curriculum has been one of the most important topics in educational circles. This implies that programs implemented in education for various reasons have not fully achieved the goals set. One of reasons for this is to “disregard localization in curriculum”. Curriculum studies are among disciplines that can play an important role in influencing humanities curriculum planning process. But lack of a suitable indigenous curriculum template has made it increasingly reliant on foreign sources and imported and translated terms are used in abundance that has been led to little attention to customs, culture, social, economic and political conditions of society. Although Iranian culture and civilization originates from the fullest range of divine teachings, the educational system has failed to provide an appropriate educational model that is appropriate to cultural conditions throughout the country. A descriptive-analytical approach has been used to answer this question. The findings suggest that in order to change the humanities curriculum into an academic system, the curriculum needs to benefit from its rich Iranian culture and civilization in addition to applying the experiences of other countries and even goes a step further and introduce to the world a pattern arising from Iranian culture and civilization.
The United States-Backed Containment of Turkey in the Eastern Mediterranean
Authors: Özdemir Çağatay
Published: July 2020

International competition over natural gas and oil has been escalating in the Eastern Mediterranean in recent years, and the region has become much more significant for many regional and global actors. This article claims that a bloc of regional actors, supported by the United States, has been following a containment policy against Turkey in the Eastern Mediterranean. By examining recent trends and developments with special focus on the policies directed against Turkey’s rights and interests in the Eastern Mediterranean, this article demonstrates how Turkey is being isolated in the region, and discusses Turkey’s reactions to its on-going containment.
A Study of Iron Oxide Nanoparticles Synthesis by Using Bacteria
Authors: Jubran Abdulsahib S. , Al-Zamely Oda M. , Al-Ammar Mahdi H.
Published: July 2020

The biosynthesis of nanoparticles by using microorganisms is developing as an ecofriendly method for nanoparticle synthesis because of its cheap, simple and non-toxic. Bacillus sp. can be used for producing iron oxide nanoparticles. In addition, it has the ability for the biosynthesis of Fe3O4 nanoparticles. The nanoparticles producing was evaluated by using ultra violate-visible (UV-visible) and Fourier-transform infrared spectroscopy (FT-IR) methods also the production and size of the nanoparticle was confirmed by X-ray Diffraction and Field Emission Scanning Electron Microscope (FESEM) to confirm the accuracy of iron oxide nanoparticles. pH, Temperature, and Incubation time of production of iron oxide nano-particle also studied.
Physiochemical Features, Qualitative and Quantitative Analysis, Present Status and Application Prospects of Polysaccharide Gums
Authors: Bokov O. Dmitry , Sokurenko S. Maria , Malinkin D. Alexei , Khromchenkova P. Elena , Shevyakova V. Lyudmila , Bessonov V. Vladimir
Published: July 2020

Gums, generally plant-derived polysaccharides, have been widely used in various fields of the pharmaceutical and food industries in recent years. Natural gums are formed as a result of a protective reaction to plant damage or due to negative conditions (drought), as a result of the destruction of cell walls (gummosis); also bacteria cultures, seaweeds can serve as gum sources. Gums are of great interest due to the wide application spectrum; it is based both on their physicotechnological (structure-forming agents) and the biological properties (inertness). This is an important factor in the development of food products and drugs. They also find applications in cosmetics, inks, paper, and textiles. The article aims to summarize the numerous obtained data and to establish current and prospects for gum quality control and application.
Impact of Quality Risk Management Process in Pharmaceutical Industry to Curtail the Non-Conformity
Authors: Jeyaprakash Raju Mari , Sharma Aachchhadita , Bora Rinchi , Chandra Abinash
Published: July 2020

Risk is intertwined with every drug product in a market. This article’s intent is to provide ground rule and praxis of different tools for quality risk management (QRM) in various aspects of pharmaceutical science. QRM comprises of tools and processes which helps in establishing objectives. Hence they are also known as Enablers. Enablers help in risk mitigation of product quality throughout a lifecycle in such a way that benefit outweighs the risk. The key properties of Enablers or QRM, i.e., attempts made, solemnness and records shall be compatible with risk scale. The Enablers accomplishment gives recognized, obvious and steps of Enabler process produced by regeneratable methods which is based on customary comprehension to evaluate feasibility, ability to find out risk prejudice. The QRM or Enabler tools can assist the manufacturing company and regulatory bodies to scrutinize, handle, notify, and inspect the risk.
Development and Validation for Simultaneous Estimation of Sofosbuvir and Daclatasvir Dihydrochloride in Pharmaceutical Dosage form by Ratio Derivative and Dual Wavelength Methods
Authors: Rathod Sapna M , Patel Paresh U
Published: July 2020

Development and validation of new simple, sensitive, accurate and precise spectrophotometric method involving ratio derivative and dual-wavelength method, was done as per ICH Q2 (R1) for simultaneous estimation of Sofosbuvir (SOFO) and daclatasvir dihydrochloride (DACLA) in a combined dosage form. The overlapping in the spectra of both drugs was the reason for the selection of both methods. The absorbance difference (ΔA) value between 235.8 nm and 270.6 nm was selected for the quantitative determination of SOFO, where DACLA gives equal absorbance at the selected wavelength in the dual-wavelength method (Method A). The determination of DACLA is done quantitatively by measuring the difference in absorbance value at 249 nm and 268.6 nm where SOFO gives equal absorbance at a selected wavelength. Ratio spectra method (Method B) was based on dividing the spectra of a mixture with standard spectra of one of the analytes, and the first derivative spectra was recorded with Δλ = 8 nm and scaling factor 1. The amount of SOFO and DACLA was estimated in the binary mixtures by computing the first derivative signal at 247.0 nm and 341.0 nm, respectively. The calibration curve was linear in the concentration range of 10–90 μg/mL for SOFO and 4–20 μg/mL for DACLA for both the methods. The methods were successfully applied for the simultaneous determination of these drugs in combined dosage form with acceptable recoveries.
Quality Assurance in Drug Assaying and Pharmacokinetics-Blood Protein Evaluation in Calibration Curves
Authors: Naidoo S. , Vallie S.
Published: July 2020

In bioanalytical drug assays, plasma protein/albumin content can challenge the biomatrix and reduce drug recovery through the albumin-binding affinity (ABA) of drug molecules. Global quality assurance in sample preparation for analyte quantification during bioavailability assessments has evolved extensively, and the quality standards of the strictly regulated current global quality controlled drug manufacturing processes (cGQMP) now apply in pharmacokinetics (PK) studies. Previous analyses in large clinical trials had found that laboratory-prepared calibrator plasma/serum protein levels differed significantly from those of patients with occasional hyperproteinemia/hypoproteinemia and disease-related hyperalbuminemia/hypoalbuminemia. We, therefore, investigated improving assay accuracy by including adjustments for patient plasma/serum protein levels in protein evaluation calibrations curves (PROTEC). Using a combined PROTEC of two calibrators (with 1.6 ± 0.5 g/dL and 4.3g/dL albumin, respectively) to test rifampicin recovery from patients with hypoalbuminemia (1.6 ± 0.5 g/dL), we found that relative accuracy of drug recovery differed by minimum 0.1% for low ABA drugs and maximum andgt;20% for moderate ABA drugs. Assay accuracy improved after accommodating for varying patient plasma/serum protein levels. We, therefore, propose using patient-calibrator PROTEC-PK in validation assay development/therapeutic drug monitoring to ensure that patient albumin levels are within acceptable validation accuracy ranges.
Dijital Ekonomide Finansal Raporlamaya İlişkin Sorunlar ve Türkiye Açısından Çözüm Önerileri
Authors: ARTAR Yusuf , KIYMETLİ ŞEN İlker
Published: July 2020

Bilgi ve iletişim
teknolojilerinin (BİT) gelişmesiyle birlikte, dünyada dijital ekonominin
kullanımı her geçen gün artmaktadır. Diğer taraftan, dijital ekonomi gelişmeye devam ederken, mevcut finansal raporlama
kuralları dijital ekonomi faaliyetleri açısından yetersiz kalmaktadır.
Özellikle dijital ekonomi alanında ortaya çıkan yeni terimler, günümüzde ilgililer tarafından farklı algılanabilmekte;
işletmelerin diğer birimlerinde olduğu gibi muhasebe birimlerinde de farklı
yorumlara yol açabilmekte; bunun sonucunda da aynı olaya ilişkin farklı
uygulamalarda bulunulabilmektedir. Dijital ekonomide finansal raporlamaya ilişkin
sorunlar; başta defter ve kayıt düzenine ilişkin olmak üzere, internet
sitelerinin, gayri maddi varlıkların ve müşteri listelerinin finansal
raporlamasında ortaya çıkmaktadır. Bu çalışmanın amacı, dijital ekonomide
finansal raporlamaya ilişkin sorunları ortaya koymak ve bu sorunlara Türkiye
açısından çözüm önerilerinde bulunmaktır. Bu amaç doğrultusunda, söz konusu
sorunlar ayrıntılı bir şekilde ele alınmış ve bu sorunlara Türkiye açısından
çözüm önerileri getirilmiştir.
Konaklama İşletmelerinde Hizmet Hatası Telafi Stratejilerinin Kurumsal İtibara Etkisi
Authors: AKGÖZ Erkan , KRASNİKOVA Darya
Published: July 2020

Bu araştırma insan gücüne dayalı ürün ve hizmet üreten işletmelerde gerçekleşen hizmet hatalarını, bunların telafisi ile ilgili ne gibi stratejilerin uygulandığını belirlemek için hazırlanmıştır. Araştırmanın bir diğer amacı da hizmet hatası stratejilerinin kurumsal itibara etkisini belirlemektir. Bunun için de turizm faaliyetine katılanlara yönelik bir araştırma gerçekleştirilmiştir. Araştırma için gerekli veriler tek bir kişiye ya da alana bağlı kalınmadan, bireysel olarak 392 kişinin anket sorularına vermiş olduğu cevaplardan elde edilmiştir. Elde edilen verilere göre hataların büyük bir bölümü temizlik ve hijyen kaynaklı olduğu, bununla birlikte işletmelerde kullanılan araç ve gereçlerin arızalı, eksik veya kalitesiz olmasından kaynaklandığı saptanmıştır. Turizm sektöründe karşılaşılan hataların çoğunlukla restoran, ön büro ve kat hizmetleri departmanlarında olduğu da belirlenmiştir. Hizmet hatası ile karşılaşanlar ise sorun veya şikâyetlerini sırasıyla hizmet sunan personele, işletme yetkilisine ve departman sorumlularına iletmektedirler. Turizm faaliyetine katılanlar işletmelerde karşılaşmış oldukları olumsuzlukları ailesine, yakın arkadaşlarına veya çevresindeki insanlara anlatarak göstermektedirler. Araştırmada turizm faaliyetine katılanlar hizmet hatası ile karşılaştıkları işletmeye tekrar gitmek istemediklerini de belirtmektedirler.
Borsa İstanbul Sürdürülebilirlik Endeksinde Sürekli Olarak Yer Alan Şirketlerin Sürdürülebilirlik Faaliyetlerinin Analizi
Authors: KARADENİZ Erdinç , UZPAK Buket
Published: July 2020

Bu araştırmanın amacı Küresel Raporlama Girişimi ilkeleri çerçevesinde Borsa İstanbul (BIST) Sürdürülebilirlik Endeksinde sürekli olarak yer alan şirketlerin sürdürülebilirlik faaliyetleri ile bu faaliyetleri raporlama düzeylerini analiz etmek ve söz konusu şirketlerinin eksikliklerinin veya varsa üstün taraflarının neler olduğunu saptamaktır. Bu amaçla BIST Sürdürülebilirlik Endeksi’nde 2014 yılından bu yana her yıl yer alan 7 şirketin kurumsal web siteleri ile 2018 yılına ait faaliyet raporları, Küresel Raporlama Girişimi ilkeleri olan ekonomik, çevresel ve sosyal faktörler çerçevesinde içerik analizi ile incelenmiştir. Analiz sonucunda BIST Sürdürülebilirlik Endeksi’nde yer alan şirketlerin ekonomik, çevresel ve sosyal bağlamda duyarlı oldukları, gerçekleştirdikleri faaliyetleri ve duyarlılıklarını belgeler, sertifikalar, politikalar ile destekledikleri ortaya konmuştur. Buna karşın şirketlerin sürdürülebilirlik faaliyetleri ve bu faaliyetlerin raporlanması bağlamında hem bütünsel hem de ekonomik performanslarının kurumsal web siteleri ve faaliyet raporları açısından ayrıştığı ve paylaşılan bilgi düzeylerinin farklılık gösterdiği saptanmıştır. Ayrıca şirketlerin kurumsal web siteleri ile faaliyet raporlarında çevresel bağlamda en az yer verdikleri unsurların biyolojik çeşitlilik ve çevresel şikâyet mekanizması olduğu gözlemlenmiştir. Sosyal bağlamda ise şirketlerin kurumsal web siteleri ile faaliyet raporlarında en az verdikleri unsurların toplumsal bağlamda şikâyet mekanizması ile yerli halkın hakları olduğu saptanmıştır.
Unraveling the SARS-CoV-2 Main Protease Mechanism Using Multiscale DFT/MM Methods
Authors: Ramos-Guzmán Carlos A. , Ruiz-Pernía J. Javier , Tuñón Iñaki
Published: July 2020

We present a detailed theoretical analysis of the reaction mechanism of proteolysis catalyzed by the main protease of SARS-CoV-2. Using multiscale simulation methods, we have characterized the interactions stablished by a peptidic substrate in the active site and then we have explored the free energy landscape associated to the acylation and de-acylation steps of the proteolysis reaction, characterizing the transition states of the process. Our mechanistic proposals can explain most of the experimental observations made on the highly similar ortholog protease of SARS-CoV. We point out to some key interactions that may facilitate the acylation process and thus can be crucial in the design of more specific and efficient inhibitors of the main protease activity. In particular, from our results, the P1’ residue can be a key factor to improve the thermodynamics and kinetics of the inhibition process.
Machine Learning to Reduce Reaction Optimization Lead Time – Proof of Concept with Suzuki, Negishi and Buchwald-Hartwig Cross-Coupling Reactions
Authors: Huerta Fernando , Hallinder Samuel , Minidis Alexander
Published: July 2020

To date, optimizing reactions let alone predicting the outcome (yield) of known reactions requires expert knowledge and can at best be obtained by computationally complex and expensive modelling. The present investigation tests if machine learning represents a viable approach for predicting a model reaction outcome that could be put into daily production. A prerequisite was replacing advanced scripting techniques with a more approachable data science platform such as Knime®. The Palladium catalyzed Suzuki-Miyaura, Negishi and Buchwald-Hartwig reactions were selected for a classification model of high/low yielding outcome combined with a selection of reaction conditions stemming from a commercial database. Here we present preliminary results of a random forest-based classification model using readily calculated standard medicinal chemistry descriptors from substrates and products yielded high ROC AUC of up to 96%. The descriptors used in the model do not convey anything about the reactivity, only 1D- and 2D- structural information, and performed equal or better than fingerprints, both in terms of prediction and computational requirements. One of the major challenges was the quality of the data and its subsequent curation.
高中数学教学中德育教育实践案例——以随机事件的概率为例
Authors: 邓 脉红
Published: July 2020

数学是一门科学性非常强的学科，其中渗透着许多德育教育因素，根据数学学科的特点，可以对学生展开德育培养，培养其爱祖国、爱社会主义、爱科学教育以及辩证唯物主义精神，让学生形成一丝不苟、实事求是的精神、坚持不懈的精神、积极的学习习惯以及独自思考、不退缩的精神。高中的数学教师在新时期落实本学科核心素养的前提下，要紧跟国家教育方针理念，培养学生在“德”方面的素质，使得学生不仅能够在科学文化素养方面有所建树，还能提升自我道德层面的修养。
基于建筑设计相融合的建筑物理教学改革与实践
Authors: 邢 双军 , 许 瑞萍
Published: July 2020

论文针对建筑物理课程的教学现状与存在的问题，秉持课程定位与行业发展需求相对接，课程教学内容与建筑学专业主干课程相融合的原则，对建筑物理课程进行教学改革创新与实践。通过采取课堂讲授专题化、教学方法多元化、教学内容模块化以及考核过程化等改革措施，增加了课程兴趣引力，改善了课堂互动体验，提高了知识能力转化，调动了学生主动学习，取得了较好的教学效果。
¿Estamos obligados a publicar? O cómo traicionar a la Universidad cuando no se investiga y no se publica
Authors: De Pablos José Manuel
Published: July 2020

Uno de los fundamentos de toda idea periodística aconseja no titular con una interrogante, cosa que he hecho en esta ocasión. El lector espera, con todo derecho y razón, que le aclaremos las situaciones y no que le ofrezcamos asuntos sin respuesta. Así y todo, de esa manera lo he hecho en esta ocasión. ¿Se trata de un lapsus, un error? 

estamos obligados a publicar, a dejar de ser repetitivos en nuestra docencia, a presentar alguna vez la originalidad de cualquier trabajo que merezca el título de investigativo, de ser una investigación académica, de ser el resultado de una pesquisa que trata de responder a las hipótesis de partida, que sigue el curso de la metodología aplicada.
Critical analysis of the discourse on Judith Butler´s visit to the country in the most popular online news portals
Authors: Belisario Katia Maria , Menders Kaitlynn
Published: July 2020

In November 2017, feminist theorist Judith Butler travelled to Brazil to participate in an international conference. During the event, protesters gathered, carrying signs, chanting slogans, and burning an effigy of her while shouting, “Burn the witch!” According to media reports, these protesters wanted to preserve notions of the traditional nuclear family within Brazil and protect children against Butler’s “diabolical gender ideology”, which includes her theory that gender is a social construct and a cultural interpretation that overlaps with biological determinism. The protest attracted mainstream media attention. This article aims to identify the key discourses used by anti- and pro-Butler activists commenting in the most popular news portals in the country, UOL and G1. The questions guiding this study are: 1) How is feminism represented in Brazil? 2) How do protesters and counter-protesters understand and argue about “gender ideology”? The methodology used is the critical discourse analysis of online comments of readers of both portals.
Prevalence of antibiotic resistance Escherichia coli isolated from Pangasius catfish (Pangasius hypophthalmus) fillet during freezing process at two factories in Mekong Delta Vietnam
Authors: Salako D.A. , Trang P.N. , Ha N.C. , Miyamoto T. , Ngoc T.T.A.
Published: July 2020

Total of 261 samples of fish and environmental samples (i.e. wash water, swabs of hand/
gloves of workers, fish contact surfaces i.e. knives, cutting boards and working tables)
were collected from two Pangasius processing factories (PPF1 and PPF2). A total of
seventy-one (71) isolates of Escherichia coli were selected to study the prevalence of
antibiotics resistance using disk agar diffusion method. Overall, it was determined that
61% (22/36) of PPF1 isolates were resistant except to colistin while 68.57% (24/35) of
PPF2 isolates were resistant except kanamycin. High resistance was against ampicillin in
both PPF1 and PPF2 isolates (47.22% and 42.86%), followed by cefotaxime (33.33% and
40%) respectively. Varying resistance response to all other tested antibiotics such as
streptomycin, meropenem, tetracycline, sulfamethoxazole/trimethoprim and nalidixic acid
was also observed among the E. coli isolates from both factories. About 50% of the multidrug resistant (3-9 antibiotics) among PPF1 were observed whereas there were 45.83%
multi-drug resistant (3-7 antibiotics) among PPF2 isolates. The result from this study
reflected that there was a prevalence of multi-drug resistance of E. coli isolated during the
processing of Pangasius at the studied factories. Therefore, there is a need for an effective
risk management assessment models and management plans from stakeholders involved in
the Pangasius value chain (i.e. farmers, processors and government) to ensure the food
safety of production chain
Seeing and Being Seen: Exploring how people use their orientation to the camera during video interaction
Authors: Pirini Jesse
Published: July 2020

No description supplied
Automatically evolving difficult benchmark feature selection datasets with genetic programming
Authors: Lensen Andrew , Xue Bing , Zhang Mengjie
Published: July 2020

© 2018 Copyright held by the owner/author(s). There has been a wealth of feature selection algorithms proposed in recent years, each of which claims superior performance in turn. A wide range of datasets have been used to compare these algorithms, each with different characteristics and quantities of redundant and noisy features. Hence, it is very difficult to comprehensively and fairly compare these feature selection methods in order to find which are most robust and effective. In this work, we examine using Genetic Programming to automatically synthesise redundant features for augmenting existing datasets in order to more scientifically test feature selection performance. We develop a method for producing complex multi-variate redundancies, and present a novel and intuitive approach to ensuring a range of redundancy relationships are automatically created. The application of these augmented datasets to well-established feature selection algorithms shows a number of interesting and useful results and suggests promising directions for future research in this area.
Finite volume schemes for Boussinesq type equations
Authors: Dutykh Denys , Katsaounis Theodoros , Mitsotakis Dimitrios
Published: July 2020

Finite volume schemes are commonly used to construct approximate solutions to
conservation laws. In this study we extend the framework of the finite volume
methods to dispersive water wave models, in particular to Boussinesq type
systems. We focus mainly on the application of the method to bidirectional
nonlinear, dispersive wave propagation in one space dimension. Special emphasis
is given to important nonlinear phenomena such as solitary waves interactions.
This Paper Is an Artefact: On Open Science Practices in Design Science Research Using Registered Reports
Authors: Doyle Cathal , Luczak-Roesch Markus
Published: July 2020

No description supplied
Patterns of testing theory with human subjects: A design science perspective
Authors: Enwereuzo I , Antunes Pedro , Johnstone David
Published: July 2020

© 2019 Association for Information Systems. All rights reserved. This paper addresses the challenges of theory testing. Adopting the design science paradigm, we address this challenge by delimiting the line that separates theory building from theory testing by conceptually characterizing its essential aspects: the relationships between humans, organizations and technology, which led to the development of a conceptual framework for theory testing. Practically, the methods, processes, instruments, and tools needed to acquire and analyze data for theory testing is considered, leading to the development of a pattern system. Card sorting was used as an evaluation strategy for the conceptual framework and the pattern model.
From Individual to Collective Chirality in Metal Nanoparticles*
Authors: Guerrero-Martinez Andrés , Alonso-Gómez José Lorenzo , Auguié Baptiste , Cid M Magdalena , Liz-Marzán Luis M
Published: July 2020

No description supplied
Technology Knowledge in Marketing Ecosystems: a Framework and Research Agenda
Authors: Gordon Mary , Cranefield Jocelyn
Published: July 2020

No description supplied
Barra transpalatina, características e aplicações clínicas: revisão de literatura
Authors: Santos Marlucio Prates dos , Santos Dênis Clay Lopes dos , Flaiban Everton , Negrete Daniel , Santos Raquel Lopes dos
Published: July 2020

O estudo apresentado tem por objetivo discorrer sobre a utilização da barra transpalatina na prática clínica e ortodôntica. A ativação da barra gera uma série de forças clinicamente úteis para mover os molares superiores. Este dispositivo de fácil confecção apresenta importantes funções tais como: auxiliar na ancoragem, expansão e contração dos arcos, correção das rotações de molares, controle do torque e inclinações de molares, controle da extrusão de molares, correção da mordida cruzada unilateral e auxiliar no movimento de distalização dos molares no arco superior. O conhecimento das possibilidades de emprego da barra transpalatina constitui um importante recurso auxiliar na terapia ortodôntica.
Celulite em região cervicofacial: relato de caso
Authors: Flandes Marcelle Pelegrino , Vallim Paolla Camacho , DIAS Leonardo Braun Braun Galvão Maximo , Paulesini Junior Walter
Published: July 2020

A maioria das infecções de origem odontogênica, se origina a partir de necrose pulpar com invasão bacteriana no tecido periapical e periodontal, podendo levar à formação de abscesso, quando a infecção prevalece sobre as resistências do hospedeiro. Em situações nas quais a coleção purulenta não é capaz de drenar através de superfície cutânea ou mucosa bucal, o abscesso pode se estender através dos planos fasciais dos tecidos moles, patologia que se denomina celulite. O seu tratamento varia desde administração de antibioticoterapia parenteral de amplo espectro à drenagem sob anestesia geral.