bluuebunny/crossref_metadata_2025 huggingface dataset:
The relationship between trait awe and procrastination: A mediated model with moderation
Authors: Song Jinze , Zhang Chao , Li Tong
Published: November 2022

The current study aims to examine the effect of trait awe on college students’ procrastination with a focus on confirming the mediating role of stress and the moderating role of future time perspective (FTP). Measures of procrastination, trait awe, stress, and future time perspective were completed by 512 Chinese college students. The results indicate that trait awe had a negative effect on procrastination, that stress was a significant mediator between trait awe and procrastination, and that FTP moderated the mediation effect. These findings not only demonstrate the crucial role of awe in alleviating procrastination but also elucidate the underlying mechanisms and relevant populations. Limitations and directions for future research were also discussed.
The influence of parent–child attachment on school adjustment among the left-behind children of overseas Chinese: The chain mediating role of peer relationships and hometown identity
Authors: Zhang Huilan , Li Zihan , Yan Xiaoqiu , Deng Chunkao
Published: November 2022

Background

The left-behind children of overseas Chinese are a kind of vulnerable children in the eastern coastal areas of China. Previous studies have shown that there are problems in their school adjustment. This study explored the relationship between parent–child attachment and school adaptation among the left-behind children of overseas Chinese parents, as well as the chain mediating role of peer relationships and hometown identity.

Methods

A total of 1,047 students in grades 3–8 from 5 schools in Zhejiang Province were selected by cluster sampling. The cross-sectional survey was compiled from the Inventory of Parent and Peer Attachment, the Adaptation subscale of the Adolescent Mental Health Quality Questionnaire–Chinese Version, the Hometown Identity Scale, and the Student Peer Relationship Scale. Structural equation modeling was used to test the conceptual model.

Results

The results showed that the influence of parent–child attachment on school adjustment among the left-behind children of overseas Chinese was mediated by hometown identity. Moreover, this impact was also sequentially mediated by peer relationships and hometown identity.

Conclusion

This study revealed peer relationships and hometown identity as underlying mechanism that explained the influence of parent–child attachment on school adjustment among left-behind children. It may provide empirical support for future interventions.
From entrepreneurial cognition to entrepreneurial intention and behavior: The case of higher educational institutions in China
Authors: Chen Su , Shen Wenbin , Tan Xinyu , Liu Rongzhi
Published: November 2022

Entrepreneurship has been called “high quality employment” in China. Therefore, universities have paid more attention to entrepreneurship education, which is a crucial element for entrepreneurial success. Based on the theory of “informed intentions” planned behavior and dual cognitive processing theory, this manuscript studies the relationship among entrepreneurial cognition, entrepreneurial intention, recognition perception of university entrepreneurship education, and entrepreneurial behavior from the perspective of mass innovation and mass entrepreneurship in China. The hypotheses are tested using a hierarchical linear regression model based on data from 786 valid questionnaires from more than 400 universities across China. This study finds that student’s entrepreneurial cognition positively affects their entrepreneurial behavior, and entrepreneurial intention plays a mediating role by positively strengthening the relationship between these two, and that the recognition perception of university entrepreneurship education strengthens the positive relationship between entrepreneurial intention and entrepreneurial behavior. These findings provide a new perspective and framework for studying the entrepreneurial cognitive education of university students, and they have certain practical implications for the reform of entrepreneurship education in China.
Burnout Integrative Measure: A preliminary validation among French college students
Authors: Berjot Sophie , Weber Tiphanie , Huyghebaert-Zouaghi Tiphaine
Published: November 2022

The aim of this research was to create and validate an integrative measure of college students’ burnout. A burnout measure was proposed and extended the three-dimensional conceptualization of burnout (weariness, detachment toward social objects, inadequacy). Based on prior research, our conceptualization and measure distinguished between types of weariness (cognitive, physical, and emotional weariness) and between different targets of detachment toward social objects (studies, other students, teachers). We also relied on negatively worded items to assess inadequacy, as suggested in the literature. The criterion-related validity of our Burnout Integrative Measure (BIM) was examined by exploring associations with two closely related constructs, namely stress and depression. The participants are 905 students in several disciplinary (psychology, nursing care, medicine, science and techniques in sports and physical activities). Results from structural equation modelling provided support for a third-order model encompassing the different targets of detachment, the distinct types of weariness, and inadequacy. The third-order model had a better fit than a first-order model (with a global burnout) and a second-order model (with no distinction between the targets of detachment and the types of weariness). Correlations with related constructs (depression and stress) mostly confirmed our hypotheses. Results and practical implications are discussed.
Enhance or inhibit? Unveiling the influence of chairman’s hometown attachment on the corporate philanthropy–Corporate financial performance relationship
Authors: Chen Limin , Bu Xuelin
Published: November 2022

Although there have been numerous studies on the relationship between corporate philanthropy and corporate financial performance (CFP), theoretical analysis focusing on the legitimacy-based mechanism and the moderating role of key executives’ psychological characteristics is scarce. Hometown attachment is a special form of place attachment in environmental psychology, which reflects people’s psychological attachment to their hometown and the state of maintaining an intimate emotional connection with it. Based on Scott’s three-pillar institutional perspective, this study traces its origins from the Chinese cultural context, and discusses the legitimacy basis of donations in the Chinese cultural context and why donations can improve CFP. On this basis, the moderating effect of the chairman’s hometown attachment on the corporate donation–performance relationship is empirically tested. Through logical deduction, hometown attachment may form legitimacy pressure to weaken the above relationship or leverage more legitimacy resources to strengthen such a relationship. Which effect dominates? The empirical results in this study of A-share listed firms from 2009 to 2018 show that the moderating role of hometown attachment is more in line with the resource theory than the former pressure theory. Further research shows that the government and consumers are important providers of these legitimacy resources. This study reveals the mechanism for legitimacy acquisition through corporate donations in the Chinese context and answers the question of what the chairman’s hometown attachment brings about to their donation performance, providing some inspiration for practice.
Attentional disengagement effect based on relevant features
Authors: Hao Yuxiang , Zhang Qi , Wang Zile , Sun Mengxuan
Published: November 2022

In visual search tasks, distractors similar to the target can attract our attention and affect the speed of attentional disengagement. The attentional disengagement refers to shifting attention away from stimuli that are not relevant to the task. Previous studies mainly focused on the attentional disengagement of one feature dimension. However, the mechanisms of different feature dimensions on attentional disengagement in single and conjunction visual search remain unclear. In the current study, we adopted the oculomotor disengagement paradigm and used saccade latency as an indicator to explore the effects of different feature dimensions of center stimuli on attentional disengagement. In both single and conjunction feature search tasks, participants began each search by fixating on a center stimulus that appeared simultaneously with search display but would not be the target. Participants were instructed to ensure the first saccade to the target location. In Experiments 1A (single feature search) and 1B (conjunction feature search), we found that the attentional disengagement was significantly delayed or accelerated when center stimuli shared color features with the target or salient distractor, but not in shape feature. Moreover, we found that the difference between the two feature dimensions might be caused by their different search difficulty (Experiment 1C). Therefore, in Experiment 2, we matched the difficulty of searching for color and shape tasks before exploring whether there were differences in the effects of different feature dimensions on attentional disengagement. However, the results in Experiment 2 were similar to those in Experiment 1A, indicating that the different effects of feature dimensions on attentional disengagement were caused by feature asymmetry. Therefore, in Experiment 3, we improved the salient discernibility of shape dimension and matched color search to it. The results showed that although the attentional disengagement was delayed in shape dimension, it was still smaller than that in color dimension. Our results supported that goal-oriented attention sets were the main cause of delayed attentional disengagement. By series of experiments, we found that the utilization of different feature dimensions was associated with task difficulty and the features asymmetry in both single and conjunction visual search.
Effect of semantic distance on learning structured query language: An empirical study
Authors: Shin Shin-Shing
Published: November 2022

Students of database courses usually encounter difficulties in learning structured query language (SQL). Numerous studies have been conducted to improve how students learn SQL. However, learning SQL remains difficult. This study analyzed the difficulties in learning SQL from the viewpoint of semantic distance by using semantic network theory. An experiment involving a database course was performed to assess the influence of semantic distance on learners’ understanding of SQL. The participants were requested to perform a query-writing task at the end of the course to investigate their understanding of SQL. The data analysis results indicated that the participants developed a better understanding of the formulation-to-planning transformation than the planning-to-coding transformation. This implies that the semantic distance of the planning-to-coding transformation is greater than that of the formulation-to-planning transformation, and the semantic distance of the planning-to-coding transformation is attributable to the semantic transformation from natural language to SQL, which are two essentially different languages and belong to different knowledge categories. Accordingly, this study concludes that SQL learning difficulties can mainly be ascribed to the planning-to-coding transformation because the large semantic distance. The findings suggest that SQL instructions should emphasize the semantic mapping of the planning-to-coding transformation by incorporating materials related to the transformation and should shorten the semantic distance involved in learning SQL. These two principles can be used to evaluate the effectiveness of SQL teaching methods in assisting SQL learning, and motivate researchers to develop more effective teaching methods from the viewpoint of semantic distance.
Application of social identity models of collective action to facilitate participation in groundwater aquifer storage and recovery management
Authors: Valizadeh Naser , Bagheri-Gavkosh Mehdi , Bijani Masoud , Hayati Dariush
Published: November 2022

Aquifer storage and recovery (ASR) is considered as an innovative method and an alternative one for sustainable management of water resources that has, in recent years, attracted the attention of experts and thinkers. Implementation of this method would entail the participation and collective action of various stakeholders. In this process, farmers are considered as the most important stakeholders; and limited studies have been conducted on their intentions to participate in collective actions of ASR management. In this regard, the investigation of farmers’ intention to participate in ASR and its determinants, using social identity models of collective action, was selected as the main purpose of the present study. For this purpose, using a cross-sectional survey, 330 Iranian farmers were interviewed. In this study, the ability of the dual-pathway model of collective action (DPMCA) and the encapsulation model of social identity in collective action (EMSICA) was evaluated and compared to explain farmers’ intentions towards participation in ASR management. The results revealed that the both models had good predictive powers. However, DPMCA was a stronger framework than EMSICA for facilitating farmers’ collective behaviors in the field of participation in ASR management. This is one of the most important results of the present research that might be used by various users including decision makers, managers, and practitioners of water resources management in Iran and generally the world. Finally, the creation of a “we thinking system” or social identity in the field of ASR management was highlighted as one of the most important take-home messages.
Altered striatal functional connectivity and structural dysconnectivity in individuals with bipolar disorder: A resting state magnetic resonance imaging study
Authors: Okanda Nyatega Charles , Qiang Li , Jajere Adamu Mohammed , Bello Kawuwa Halima
Published: November 2022

Objective

Bipolar disorder (BD) is a mood swing illness characterized by episodes ranging from depressive lows to manic highs. Although the specific origin of BD is unknown, genetics, environment, and changes in brain structure and chemistry may all have a role. Through magnetic resonance imaging (MRI) evaluations, this study looked into functional abnormalities involving the striatum between BD group and healthy controls (HC), compared the whole-brain gray matter (GM) morphological patterns between the groups and see whether functional connectivity has its underlying structural basis.

Materials and methods

We applied sliding windows to functional magnetic resonance imaging (fMRI) data from 49 BD patients and 44 HCs to generate temporal correlations maps to determine strength and variability of the striatum-to-whole-brain-network functional connectivity (FC) in each window whilst also employing voxel-based morphometry (VBM) to high-resolution structural MRI data to uncover structural differences between the groups.

Results

Our analyses revealed increased striatal connectivity in three consecutive windows 69, 70, and 71 (180, 182, and 184 s) in individuals with BD (p < 0.05; Bonferroni corrected) in fMRI images. Moreover, the VBM findings of structural images showed gray matter (GM) deficits in the left precentral gyrus and middle frontal gyrus of the BD patients (p = 0.001, uncorrected) when compared to HCs. Variability of striatal connectivity did not reveal significant differences between the groups.

Conclusion

These findings revealed that BD was associated with a weakening of the precentral gyrus and middle frontal gyrus, also implying that bipolar illness may be linked to striatal functional brain alterations.
Effect of virtual reality exercise on interventions for patients with Alzheimer’s disease: A systematic review
Authors: Yi Yali , Hu Yuanyan , Cui Mengxin , Wang Cheng , Wang Jibing
Published: November 2022

Virtual reality (VR) interventions are increasingly being used in rehabilitating and treating patients with neurological disorders. This study aimed to explore the effects of VR exercise interventions for patients with Alzheimer’s disease (AD). A systematic review of the published literature on randomized controlled trials of VR technology applied to patients with AD was conducted using the preferred reporting entry for systematic reviews and Meta-analysis guidelines. Descriptive analyses were performed to assess the quality of the studies in terms of the characteristics of the included studies, samples, diagnoses, types of VR technologies, subjective and objective levels of immersion, and quality of studies. Eight studies were included, including a pooled sample of 362 patients with AD. A systematic review showed that most studies focused on patients with AD’s cognitive and physical functions. The main finding was that VR interventions could help improve cognitive and physical balance in patients with AD. However, future studies should emphasize design and use well-accepted assessment tools to validate the effects of VR interventions further.
Potential mechanisms underlying the therapeutic roles of sinisan formula in depression: Based on network pharmacology and molecular docking study
Authors: Wang Hui , Liu Jiaqin , He Jinbiao , Huang Dengxia , Xi Yujiang , Xiao Ting , Ouyang Qian , Zhang Shiwei , Wan Siyan , Chen Xudong
Published: November 2022

Background

The incidence of depression has been increasing globally, which has brought a serious burden to society. Sinisan Formula (SNSF), a well-known formula of traditional Chinese medicine (TCM), has been found to demonstrate an antidepressant effect. However, the therapeutic mechanism of this formula remains unclear. Thus, the present study aimed to explore the mechanism of SNSF in depression through network pharmacology combined with molecular docking methods.

Materials and methods

Bioactive compounds, potential targets of SNSF, and related genes of depression were obtained from public databases. Essential ingredients, potential targets, and signaling pathways were identified using bioinformatics analysis, including protein-protein interaction (PPI), the Gene Ontology (GO), and the Kyoto Encyclopedia of Genes and Genomes (KEGG). Subsequently, Autodock software was further performed for conducting molecular docking to verify the binding ability of active ingredients to targets.

Results

A total of 91 active compounds were successfully identified in SNSF with the use of the comprehensive network pharmacology approach, and they were found to be closely connected to 112 depression-related targets, among which CREB1, NOS3, CASP3, TP53, ESR1, and SLC6A4 might be the main potential targets for the treatment of depression. GO analysis revealed 801 biological processes, 123 molecular functions, and 67 cellular components. KEGG pathway enrichment analysis indicated that neuroactive ligand-receptor interaction, serotonergic synapse pathways, dopaminergic synapse pathways, and GABAergic synapse pathways might have played a role in treating depression. Molecular docking suggested that beta-sitosterol, nobiletin, and 7-methoxy-2-methyl isoflavone bound well to the main potential targets.

Conclusion

This study comprehensively illuminated the active ingredients, potential targets, primary pharmacological effects, and relevant mechanism of the SNSF in the treatment of depression. SNSF might exert its antidepressant effects by regulating the signaling pathway of 5-hydroxytryptamine, dopamine, GABA, and neuroactive ligand receptor interactions. Still, more pharmacological experiments are needed for verification.
Neuropsychological predictors of vocational rehabilitation outcomes in individuals with major depression: A scoping review
Authors: Bergdolt Juliane , Sellin Pauline , Driessen Martin , Beblo Thomas , Dehn Lorenz B.
Published: November 2022

Background

Major depression is one of the leading causes of disability and limited capacity to work. Neuropsychological impairment is a common symptom in acute and remitted major depression and is associated with poor psychosocial functioning. This scoping review aimed to identify research on the role of neuropsychological functioning in outcomes of vocational rehabilitation programs in individuals with depression.

Methods

We report on the conduct of this pre-registered (https://osf.io/5yrnf) scoping review in accordance with PRISMA-ScR guidelines. PubMed and PsychInfo were systematically searched for English or German research articles published between 1990 and September 2021 that studied objective neuropsychological tests as predictors of vocational rehabilitation interventions and included participants with depression.

Results

The systematic literature search yielded no studies that specifically targeted subjects with major depression. However, eight articles published since 2016 were included in the review, analyzing data from five trials that evaluated the effectiveness of supported employment in North America and Europe in severe mental illnesses. An estimated 31% of the total number of participants included (n = 3,533) had major depression. Using a variety of cognitive tests and covariates, seven articles found that neuropsychological functioning – especially global cognition scores, verbal and visual learning and memory – significantly predicted vocational outcomes of rehabilitation programs.

Conclusion

Despite a lack of studies specifically targeting major depressive disorder, the identified literature suggests that higher baseline neuropsychological functioning predicts better vocational outcomes of supported employment programs in individuals with depression. In clinical practice, additional neuropsychological modules during return-to-work interventions might be helpful for vocational outcomes of such programs.
Social distancing and changes in drug use: Results from a cross-sectional study during the COVID-19 pandemic in Brazil
Authors: Nin Maurício Schüler , Heidrich Nubia , Almeida Felipe B. , Izolan Lucas R. , Constant Hilda M. R. M. , Freese Luana , Gomez Rosane , Barros Helena M. T.
Published: November 2022

Background

The outbreak of coronavirus disease 19 has led to measures of social distancing and quarantine worldwide. This stressful period may lead to psychological problems, including changes in substance use. In addition, sociodemographic factors are linked to changed levels of drug use and abuse observed during the COVID-19 pandemic, which are also associated with increased anxiety, depression, and other disorders. Thus, the aim of the study was to investigate (i) changes in drug use during the COVID-19 pandemic associated with social distancing, and (ii) to verify factors associated with those changes.

Methods

A web-based cross-sectional observational survey was completed by a self-selected adult general population in Brazil (N = 2,435) during September/October 2020 (first wave) before and throughout the pandemic. Key outcomes: social distancing, self-reported drug use (ASSIST), and emotional states (DASS-21).

Results

High social distancing was associated with fewer chances (prevalence ratio) of increased drug use for alcohol (0.71, CI95%: 0.64–0.80), tobacco (0.72; CI95%: 0.60–0.87), cannabis (0.65; CI95%: 0.55–0.78), and others. Low social distancing presented a higher DASS-21 score for anxiety (P = 0.017). Concerning covariates analysis by a general linear model, men (alcohol: 1. 71; cannabis: 3.86), younger age (alcohol: 0.97), less education (alcohol, tobacco, cannabis and cocaine/crack comparing several lower schooling categories vs. higher education), lower income (alcohol: 0.42; tobacco: 0.47; and cannabis: 0.36), and higher depression DASS-21 score (alcohol: 1.05; tobacco: 1.08; cannabis: 1.07; and cocaine/crack: 1.07) were associated with higher use prevalence of several drugs.

Conclusions

Individuals reporting low social distancing increased the use of most drugs during the pandemic, while high social distancing significantly decreased drug use. Anxiety and depressive states and several sociodemographic factors (men; lower income; less education) were associated with higher drug use patterns.
China's practical wisdom: Assumption of liability for endangering public health in bankruptcy proceedings—A case study of the Changchun Changsheng Biotechnology vaccine incident and the Johnson & Johnson baby powder incident
Authors: Huang Chaoyi
Published: November 2022

The assumption of liability for endangering public health has always been a legislative challenge in bankruptcy proceedings. Although it has been theoretically proven that the tort creditor should hold a position higher than that of unsecured creditors in bankruptcy proceedings, both legislation and judicial practice have been found wanting in many countries. China has witnessed large-scale domestic public health incidents where the tort debtor has entered bankruptcy proceedings while the tort claims were being settled. In Changchun Changsheng Biotechnology vaccine incident, to maintain social order and protect the rights and interests of the tort creditor, the Chinese government required the tort debtor to set up a special compensation fund of RMB 500 million and hand it over to a third party for management. This approach was mainly adopted because tort creditors can only participate in the bankruptcy distribution as an unsecured creditor, according to the Enterprise Bankruptcy Law of China, and as a result, their rights and interests cannot be guaranteed. In the context of the Enterprise Bankruptcy Law of China, this approach face predicaments of legitimacy and effectiveness. Moreover, even if the legislators follow scholars' advice and grant the tort creditor priority in bankruptcy proceedings, that would still not be enough to protect the rights and interests of the tort creditor, not to mention the possibility that the tort debtor might follow the example of Johnson & Johnson to avoid liability in practice. In fact, the Chinese government's approach is similar to that of Johnson & Johnson's, but more advisable. The Enterprise Bankruptcy Law of China (Bill of Amendment) will be submitted to the Standing Committee of the National People's Congress for preliminary deliberation this year, and the Chinese government's approach to the Changchun Changsheng vaccine case is very likely to be codified. This will resolve the predicaments of legitimacy and effectiveness that the government's current approach is facing and serve as a point of reference for the future revision of U.S. bankruptcy law and the handling of related cases.
The gender-specific bidirectional relations between chronic diseases and total bilirubin/urea in the elderly population: A 3-year longitudinal study
Authors: Wu Na , Zhai Xiangyu , Feng Mofan , Li Jie , Yu Ning , Zhang Fengwei , Li Dong , Wang Jianying , Zhang Lei , Shi Yi , He Guang , Ji Guang , Liu Baocheng
Published: November 2022

Aging is accompanied by changes in physiology over time, which remains the largest risk of chronic diseases. The aim of this study was to explore the gender-specific bidirectional relations between the risk of chronic diseases and serum traits in a 3-year longitudinal study. A hierarchical non-linear model with random effects was used to assess the temporal patterns of anthropometric and serum traits from 2017 to 2019 among 2,338 participants. To assess the directional effect between the risk of chronic diseases and serum traits, a bivariate cross-lagged panel model (CLPM) was used to estimate the structural relations of repeatedly measured variables at three different time points. Candidate SNPs were analyzed and genotyped in MassARRAY Analyzer 4 platforms. In this study, metabolic syndrome (MS) score increased with aging in females, whereas the fatty liver disease (FLD) index decreased with aging in males; the MS score was negatively correlated with TB in females, and FLD index was positively related to urea in males; CLPM showed that the MS score predicted total bilirubin (TB) in females, and urea predicted the FLD index in males. Additionally, rs2292354 in G protein-coupled receptor kinase interactor 2 (GIT2) was associated with the MS score and TB in aged females. Our study suggests the potential gender-specific causal associations between development in MS and increase in TB level in females, and rise in urea level and improved FLD index in males. The SNP rs2292354 we investigated might be a biomarker for predicting MS in the elderly Chinese Han population.
Which is the best management for women with normal cervical cytologic findings despite positivity for non-16/18 high risk human papillomaviruses?
Authors: Wu Ming , Ma Xiaotong , Li Huiyang , Li Bijun , Wang Chen , Fan Xiangqin , Fan Aiping , Xue Fengxia
Published: November 2022

Women who test positive for the human papillomavirus (HPV) but have normal cytology constitute the predominant subgroup of patients in the screening population in the post-vaccination era. The distribution of HPV genotypes changed dramatically, which was attributable to an increase in HPV vaccination coverage. These changes have created uncertainty about how to properly manage women with normal cytology, non-HPV16/18 infections, or persistent infections. Current recommendations include retesting and continued surveillance in the absence of HPV16/18 infection. However, these are not always applicable. The ability to implement genotyping or incorporate HPV16/18 with some additional high-risk HPV (HR-HPV) types for triage and management with the aim of identifying type-specific risks in this population could be acceptable. When the next set of guidelines is updated, generating potential triage strategies for detecting high-grade cervical lesions, such as the p16/Ki67 cytology assay and other alternatives that incorporate genotyping with newer tests, should be considered. Current clinical management is shifting to risk-based strategies; however, no specific risk threshold has been established in this population. Importantly, innovative triage testing should be evaluated in combination with primary screening and management. Furthermore, there is an untapped opportunity to coordinate HPV genotyping in combination with colposcopic characteristics to modify risk in this group. Hence, providing a more personalized schedule through the efficient application of risk stratification and improving the detection of pre-cancer and cancer is an option worth exploring.
Cervical cancer survival times in Africa
Authors: Drokow Emmanuel Kwateng , Fangninou Fangnon Firmin , Effah Clement Yaw , Agboyibor Clement , Zhang Yunfeng , Arboh Francisca , Deku Marie-Anne , Xinyin Wu , Wang Yue , Sun Kai
Published: November 2022

Objective

Accessibility to quality healthcare, histopathology of tumor, tumor stage and geographical location influence survival rates. Comprehending the bases of these differences in cervical cancer survival rate, as well as the variables linked to poor prognosis, is critical to improving survival. We aimed to perform the first thorough meta-analysis and systematic review of cervical cancer survival times in Africa based on race, histopathology, geographical location and age.

Methods and materials

Major electronic databases were searched for articles published about cervical cancer survival rate in Africa. The eligible studies involved studies which reported 1-year, 3-year or 5-year overall survival (OS), disease-free survival (DFS) and/or locoregional recurrence (LRR) rate of cervical cancer patients living in Africa. Two reviewers independently chose the studies and evaluated the quality of the selected publications, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA-P). We used random effects analysis to pooled the survival rate across studies and heterogeneity was explored via sub-group and meta-regression analyses. A leave-one-out sensitivity analysis was undertaken, as well as the reporting bias assessment. Our findings were reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA-P).

Results

A total of 16,122 women with cervical cancer were covered in the 45 articles (59 studies), with research sample sizes ranging from 22 to 1,059 (median = 187.5). The five-year overall survival (OS) rate was 40.9% (95% CI: 35.5–46.5%). The five-year OS rate ranged from 3.9% (95% CI: 1.9–8.0%) in Malawi to as high as 76.1% (95% CI: 66.3–83.7%) in Ghana. The five-year disease-free survival rate was 66.2% (95% CI: 44.2–82.8%) while the five-year locoregional rate survival was 57.0% (95% CI: 41.4–88.7%).

Conclusion

To enhance cervical cancer survival, geographical and racial group health promotion measures, as well as prospective genetic investigations, are critically required.
Going for gold: Sports and exercise groups for people with dementia and carers contribute to their well-being
Authors: Chadwick Claire , Hussain Aisha , Carone Laura , Yates Jen , Dening Tom
Published: November 2022

Background

Interventions involving exercise appear to have positive effects, both for people with dementia and for their carers. Quality of life and well-being are especially important outcomes. This study investigated how a sports and exercise group for people with dementia and their carers could contribute to the well-being of those attending the group.

Methods

The study was a qualitative investigation, comprising semi-structured interviews, a focus group and observations. Participants included people with dementia and carers attending the group sessions, as well as staff providing the programme. The group sessions were provided weekly by the charitable trust of a leading sports venue. Data were analysed using thematic analysis.

Results

A total of 16 participants were interviewed, including four people with dementia, eight carers, and four members of staff. Five main themes were identified: “Support to keep active and engaged is highly valued by people with dementia and carers”; “The challenges of being a carer are significant but sharing the experience really helps”; “People with dementia can have flourishing social lives”; “The group helps to maintain identity despite physical and role changes”; and “There are practical aspects of the group that make it appealing”.

Discussion

People with dementia enjoy physical activity and experience the benefits of it. The sports and exercise group had an important role in providing access to activities that people with dementia and their carers value and enjoy, but would be difficult to undertake without a facilitated and safe environment. The group benefited the well-being of both people with dementia and carers in various ways, with peer support being of particular importance for carers.
Aeroelastics-aware compensation system for soft aerial vehicle stabilization
Authors: Ruiz Fernando , Arrue Begoña C. , Ollero Aníbal
Published: November 2022

This paper describes a compensation system for soft aerial vehicle stabilization. Balancing the arms is one of the main challenges of soft UAVs since the propeller is freely tilting together with the flexible arm. In comparison with previous designs, in which the autopilot was adjusted to deal with these imbalances with no extra actuation, this work introduces a soft tendon-actuated system to achieve in-flight stabilization in an energy-efficient way. The controller is specifically designed for disturbance rejection of aeroelastic perturbations using the Ziegler-Nichols method, depending on the flight mode and material properties. This aerodynamics-aware compensation system allows to further bridge the gap between soft and aerial robotics, leading to an increase in the flexibility of the UAV, and the ability to deal with changes in material properties, increasing the useful life of the drone. In energetic terms, the novel system is 15–30% more efficient, and is the basis for future applications such as object grasping.
Managing the end of life in COVID patients. The role of palliative care in emergency departments during the pandemic
Authors: Sena Barbara , De Luca Enrico
Published: November 2022

Managing COVID-19 patients has been an extremely difficult and dramatic task, especially for emergency departments during the strongest waves of the pandemic in Italy. Medical staff and health professionals were redeployed from their work setting to COVID units; many were overwhelmed by the deaths of so many patients in a very short time. This work aimed to explore palliative care health professionals' and physicians' perceptions of end-of-life care management in COVID units during the first two waves of the pandemic in Italy. Qualitative data was collected through 24 semi-structured in-depth interviews. The participants were palliative care medical and health professionals redeployed, or in a supporting role, COVID units from the most affected areas of northern and central Italy. The interview questions were focused on four thematic areas concerning different aspects of the role and responsibilities of the palliative care specialist (physician and healthcare professional). A brief presentation of the main sociological literature on end-of-life management in hospital contexts will be firstly presented and discussed to offer a theoretical frame. Subsequently, some of the most significant results that emerged from our research will be illustrated concerning the role played by palliative care professionals during the pandemic and the relevance of the palliative care approach in emergency contexts.
Understanding barriers impeding the deployment of solar-powered cold storage technologies for post-harvest tomato losses reduction: Insights from small-scale farmers in Tanzania
Authors: Rutta Evodius Waziri
Published: November 2022

Postharvest food loss remains one of the major food security challenges in Sub-Saharan Africa (Africa). In Tanzania, it is estimated that about 50 percent of fresh tomatoes perish before reaching consumers due to poor post-harvest management. The lack of cold storage facilities is one of the leading causes of massive post-harvest tomato losses, negatively affecting farmers' livelihoods and the sector's economic contribution. For small-scale farmers in off-grid locations, the adoption of solar-powered cold storage technologies has been found to be a potential solution for reducing losses of highly perishable crops such as tomatoes. However, in Tanzania, the deployment of Solar-powered Cold Storage Technologies (SPCSTs) is limited, leaving the vast majority of rural small-scale farmers without access to such facilities. This study examined barriers impeding the deployment and uptake of Solar-powered Cold Storage Technologies in Tanzania. Farmers' perceptions about SPCSTs and constraints limiting their deployment were examined through semi-structured interviews and Focus Group Discussions (FGD) held between April and June 2021 in Kilolo district, Southeast Tanzania. Participants involved fifty-two (n = 52) small-scale tomato farmers and twenty-three (n = 23) experts and key informants from government and non-profit organizations that were purposively selected. The results show that the deployment of solar-powered cold storage technologies is constrained by limited awareness, high investment costs, low-paying capacity among farmers, and consumer preference for non-refrigerated foods. Addressing these barriers demand promoting policies and programs that attract and retain investment in cold storage technologies and improve SPCSTs affordability through flexible payment arrangements.
Development and validation of an automated basal cell carcinoma histopathology information extraction system using natural language processing
Authors: Ali Stephen R. , Strafford Huw , Dobbs Thomas D. , Fonferko-Shadrach Beata , Lacey Arron S. , Pickrell William Owen , Hutchings Hayley A. , Whitaker Iain S.
Published: November 2022

Introduction

Routinely collected healthcare data are a powerful research resource, but often lack detailed disease-specific information that is collected in clinical free text such as histopathology reports. We aim to use natural Language Processing (NLP) techniques to extract detailed clinical and pathological information from histopathology reports to enrich routinely collected data.

Methods

We used the general architecture for text engineering (GATE) framework to build an NLP information extraction system using rule-based techniques. During validation, we deployed our rule-based NLP pipeline on 200 previously unseen, de-identified and pseudonymised basal cell carcinoma (BCC) histopathological reports from Swansea Bay University Health Board, Wales, UK. The results of our algorithm were compared with gold standard human annotation by two independent and blinded expert clinicians involved in skin cancer care.

Results

We identified 11,224 items of information with a mean precision, recall, and F1 score of 86.0% (95% CI: 75.1–96.9), 84.2% (95% CI: 72.8–96.1), and 84.5% (95% CI: 73.0–95.1), respectively. The difference between clinician annotator F1 scores was 7.9% in comparison with 15.5% between the NLP pipeline and the gold standard corpus. Cohen's Kappa score on annotated tokens was 0.85.

Conclusion

Using an NLP rule-based approach for named entity recognition in BCC, we have been able to develop and validate a pipeline with a potential application in improving the quality of cancer registry data, supporting service planning, and enhancing the quality of routinely collected data for research.
Neo-Adjuvant Use of Sorafenib for Hepatocellular Carcinoma Awaiting Liver Transplantation
Authors: Minoux Kate , Lassailly Guillaume , Ningarhari Massih , Lubret Henri , El Amrani Medhi , Canva Valérie , Truant Stéphanie , Mathurin Philippe , Louvet Alexandre , Lebuffe Gilles , Goria Odile , Nguyen-Khac Eric , Boleslawski Emmanuel , Dharancy Sebastien
Published: November 2022

Data on efficacy and safety of sorafenib in a neoadjuvant setting for HCC awaiting liver transplantation (LT) are heterogeneous and scarce. We aimed to investigate the trajectory of patients treated with sorafenib while awaiting LT. All patients listed for HCC and treated with sorafenib were included in a monocentric observational study. A clinical and biological evaluation was performed every month. Radiological tumor response evaluation was realized every 3 months on the waiting list and every 6 months after LT. Among 327 patients listed for HCC, 62 (19%) were treated with Sorafenib. Sorafenib was initiated for HCC progression after loco-regional therapy (LRT) in 50% of cases and for impossibility of LRT in 50% of cases. The mean duration of treatment was 6 months. Thirty six patients (58%) dropped-out for tumor progression and 26 (42%) patients were transplanted. The 5-year overall and recurrent-free survival after LT was 77% and 48% respectively. Patients treated for impossibility of LRT had acceptable 5-year intention-to-treat overall and post-LT survivals. Conversely, patients treated for HCC progression presented high dropout rate and low intention-to-treat survival. Our results suggest that it is very questionable in terms of utility that patients treated for HCC progression should even be kept listed once the tumor progression has been observed.
Recent Developments in Low-Power AI Accelerators: A Survey
Authors: Åleskog Christoffer , Grahn Håkan , Borg Anton
Published: November 2022

As machine learning and AI continue to rapidly develop, and with the ever-closer end of Moore’s law, new avenues and novel ideas in architecture design are being created and utilized. One avenue is accelerating AI as close to the user as possible, i.e., at the edge, to reduce latency and increase performance. Therefore, researchers have developed low-power AI accelerators, designed specifically to accelerate machine learning and AI at edge devices. In this paper, we present an overview of low-power AI accelerators between 2019–2022. Low-power AI accelerators are defined in this paper based on their acceleration target and power consumption. In this survey, 79 low-power AI accelerators are presented and discussed. The reviewed accelerators are discussed based on five criteria: (i) power, performance, and power efficiency, (ii) acceleration targets, (iii) arithmetic precision, (iv) neuromorphic accelerators, and (v) industry vs. academic accelerators. CNNs and DNNs are the most popular accelerator targets, while Transformers and SNNs are on the rise.
Validation of Propidium Monoazide-qPCR for Assessing Treatment Effectiveness against ‘Candidatus Liberibacter asiaticus’ in Citrus
Authors: Yang Chuanyu , Ancona Veronica
Published: November 2022

Huanglongbing (HLB) is an important citrus disease associated with the phloem-limited, uncultured bacterium ‘Candidatus Liberibacter asiaticus’(CLas). Effective treatments against CLas have to be validated in the field, however, methods for the field assessment of treatment effectiveness are time-consuming, in part because DNA-based assays, including quantitative PCR (qPCR), cannot differentiate between live and dead bacterial DNA. The aim of this study was to develop a method for rapid the evaluation of HLB therapies in field experiments. To this aim, a DNA extraction method from citrus leaf tissues with propidum monoazide (PMA), a dye that binds covalently to dsDNA making it unavailable for amplification in subsequent qPCR reactions, was optimized. The results indicated that the efficacy of PMA-qPCR was highly dependent on the primer set used. Primers targeting the 16S region of CLas showed a clear distinction between qPCR from PMA-treated and non-treated samples, while the RNR and LJ900 primers did not show significant differences between the DNA extraction methods. The PMA-qPCR viability analysis of CLas from citrus cuttings treated with different ampicillin (Amp) concentrations showed that all concentrations reduced CLas titers significantly starting 4 days after the initial treatment, unlike the water treatment, which did not show any change. This method was used for assessing the antibacterial activity of Amp, Streptomycin, Oxytetracycline (OTC), and a water control in field tests. The PMA-qPCR results indicated that Amp and OTC displayed significant antibacterial activity against CLas by 8 days post-injection, which was not detected in the non-PMA qPCR analysis. This method could allow the rapid validation of treatments against CLas in field experiments and facilitate the implementation of effective management strategies against HLB.
Lung Lipidomic Alterations in Beagle Dogs Infected with Toxocara canis
Authors: Li Hao-Yu , Zou Yang , Xu Yue , Cai Lang , Xie Shi-Chen , Zhu Xing-Quan , Zheng Wen-Bin
Published: November 2022

Toxocariasis, mainly caused by Toxocara canis, and to a lesser extent, Toxocara cati, is a neglected parasitic zoonosis. The mechanisms that underlie the changes in lipid metabolism of T. canis infection in Beagle dogs’ lungs remain unclear. Lipidomics is a rapidly emerging approach that enables the global profiling of lipid composition by mass spectrometry. In this study, we performed a non-targeted lipidomic analysis of the lungs of Beagle dogs infected with the roundworm T. canis using liquid chromatography–tandem mass spectrometry (LC-MS/MS). A total of 1197 lipid species were identified, of which 63, 88, and 157 lipid species were significantly altered at 24 h post-infection (hpi), 96 hpi, and 36 days post-infection (dpi), respectively. This global lipidomic profiling identified infection-specific lipid signatures for lung toxocariasis, and represented a comprehensive comparison between the lipid composition of dogs’ lungs in the presence and absence of T. canis infection. The potential roles of the identified lipid species in the pathogenesis of T. canis are discussed, which has important implications for better understanding the interaction mechanism between T. canis and the host lung.