bluuebunny/crossref_metadata_2025 huggingface dataset:
Long-Term Changes in Inland Water Surface Temperature across China Based on Remote Sensing Data
Authors: Wang Rui , Yan Xin , Niu Zhenguo , Chen Wei
Published: December 2020

Water surface temperature is a direct indication of climate change. However, it is not clear how China’s inland waters have responded to climate change in the past using a consistent method on a national scale. In this study, we used Moderate Resolution Imaging Spectroradiometer (MODIS) data from 2000 to 2015 to study the temporal and spatial variation characteristics of water surface temperature in China using the wavelet transform method. The results showed the following: 1) the freezing date of China inland water has shown a significant delaying trend during the past 16 years with an average rate of −1.5 days yr−1; 2) the shift of the 0°C isotherm position of surface water across China has clear seasonal changes, which first moved eastward about 25° and northward about 15°, and then gradually moved back after the year 2009; 3) during the past 16 years, the 0°C isotherm of China’s surface water has gradually moved north by about 0.09° in the latitude direction and east by about 1° in the longitude direction; and 4) the interannual variation of water surface temperature in 17 lakes of China showed a similar fluctuation trend that increased before 2010, and then decreased. The El Niño and La Niña around 2010 could have impacts on the turning point of the annual variation of water surface temperature. This study validated the response of China’s inland surface water to global climate change and improved the understanding of the wetland environment’s response to climate change.
Linking body worn camera activation with complaints: The promise of metadata
Authors: Martain Ben R , Harinam Vincent , Ariel Barak
Published: December 2020

With the introduction of body worn cameras, new data types have emerged, including activation metadata, which is information on the extent of the implementation of body worn cameras, by whom, and under what conditions. In this paper, we propose an avenue of methodological interest: linking activation metadata with police-recorded behaviour. We take the case of complaints to examine the use of these data for investigations of officers’ misconduct. We used an observational approach, analysing 1.73 million body worn camera activations by more than 3900 frontline officers, juxtaposed with professional conduct data. We find a heterogeneous distribution of implementation, despite a ‘blanket’ body worn camera policy requiring activation. Specifically, distinct types of officers disproportionally under-activate body worn cameras. We show that body worn cameras activation rates are inversely correlated with complaints, although minimally when observed at the population level. We discuss the use of metadata for research as well as for policy.
Comparison of intravesical instillation of hyaluronic acid with intradetrusor botulinum toxin A injection or cystoscopic hydrodistention for ketamine-associated cystitis
Authors: Li Bingkun , Leng Qu , Li Chuanyin , Tan Xiao , Su Wei , Li Chaoming
Published: December 2020

Objective

This study aimed to compare the therapeutic effect of intravesical instillation hyaluronic acid with intradetrusor botulinum toxin A (BTX-A) injection or cystoscopic hydrodistention for ketamine-associated cystitis.

Methods

Thirty-six patients were evenly randomly divided into the BTX-A group or the hydrodistention group. Patients received 200 U BTX-A detrusor injections in the BTX-A group and cystoscopic hydrodistention in the hydrodistention group. Intravesical instillation of hyaluronic acid was administrated in both groups for eight times. Patients with involuntary detrusor contraction were divided into the persistent involuntary detrusor contraction group and resolved involuntary detrusor contraction group after treatment in 6 months. The predictors of persistent involuntary detrusor contraction were analyzed.

Results

Twelve months after treatment, the daytime frequency, Interstitial Cystitis Symptom Index, maximal capacity, and maximal cystometric capacity in the BTX-A group were significantly better than those in the hydrodistention group. Patients with resolution of involuntary detrusor contraction had a significantly shorter duration of ketamine, lower amount of fibrosis in pathology, and higher maximal capacity than those with persistent involuntary detrusor contraction 6 months after therapy.

Conclusion

Intravesical instillation of hyaluronic acid with intradetrusor BTX-A injection appears to be a preferable option for long-term effectiveness compared with cystoscopic hydrodistention.
Outpatient Treatment in Low-Risk Pulmonary Embolism Patients Receiving Direct Acting Oral Anticoagulants Is Associated With Cost Savings
Authors: Ghazvinian Raein , Elf Johan , Löfvendahl Sofia , Holst Jan , Gottsäter Anders
Published: December 2020

Direct oral anticoagulants (DOAC) are first line treatment for pulmonary embolism (PE). Treatment of acute PE is traditionally hospital based and associated with high costs. The aims of this study were to evaluate potential cost savings with outpatient DOAC treatment compared to inpatient DOAC treatment in patients with low risk PE. A retrospective study in patients with DOAC treated low risk PE (simplified pulmonary severity index [sPESI] ≤ 1) admitted to 8 hospitals during 2013-2015. Health care costs were compared in 223(44%) patients treated as outpatients and 287(56%) treated in hospital. Total cost per patient was 8293 EUR in the inpatient group, and 2176 EUR in the outpatient group (p < 0.001). Total costs for inpatients were higher (p < 0.001) compared to outpatients in both subgroups with sPESI 0 and 1. In multivariate analysis, type of treatment (in- or outpatient, p = < 0.001) and sPESI group (0 or 1, p = < 0.001) were associated with total cost below or above median, whereas age (p = 0.565) and gender (p = 0.177) was not. Adherence to guidelines recommending outpatient treatment with DOAC in patients with low risk PE enables significant savings.
An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs
Authors: Holt Ian , Fuller Heidi R. , Schindler Roland F. R. , Shirran Sally L. , Brand Thomas , Morris Glenn E.
Published: December 2020

Background

Popeye domain-containing proteins 1 and 2 (POPDC1 and POPDC2) are transmembrane proteins involved in cyclic AMP-mediated signalling processes and are required for normal cardiac pacemaking and conduction. In order to identify novel protein interaction partners, POPDC1 and 2 proteins were attached to beads and compared by proteomic analysis with control beads in the pull-down of proteins from cultured human skeletal myotubes.

Results

There were highly-significant interactions of both POPDC1 and POPDC2 with XIRP1 (Xin actin binding repeat-containing protein 1), actin and, to a lesser degree, annexin A5. In adult human skeletal muscle, both XIRP1 and POPDC1/2 were present at the sarcolemma and in T-tubules. The interaction of POPDC1 with XIRP1 was confirmed in adult rat heart extracts. Using new monoclonal antibodies specific for POPDC1 and POPDC2, both proteins, together with XIRP1, were found mainly at intercalated discs but also at T-tubules in adult rat and human heart.

Conclusions

Mutations in humanPOPDC1,POPDC2and in humanXIRP1, all cause pathological cardiac arrhythmias, suggesting a possible role for POPDC1/2 and XIRP1 interaction in normal cardiac conduction.
Digital health developments and drawbacks: a review and analysis of top-returned apps for bipolar disorder
Authors: Lagan Sarah , Ramakrishnan Abinaya , Lamont Evan , Ramakrishnan Aparna , Frye Mark , Torous John
Published: December 2020

Background

Although a growing body of literature highlights the potential benefit of smartphone-based mobile apps to aid in self-management and treatment of bipolar disorder, it is unclear whether such evidence-based apps are readily available and accessible to a user of the app store.

Results

Using our systematic framework for the evaluation of mental health apps, we analyzed the accessibility, privacy, clinical foundation, features, and interoperability of the top-returned 100 apps for bipolar disorder. Only 56% of the apps mentioned bipolar disorder specifically in their title, description, or content. Only one app’s efficacy was supported in a peer-reviewed study, and 32 apps lacked privacy policies. The most common features provided were mood tracking, journaling, and psychoeducation.

Conclusions

Our analysis reveals substantial limitations in the current digital environment for individuals seeking an evidence-based, clinically usable app for bipolar disorder. Although there have been academic advances in development of digital interventions for bipolar disorder, this work has yet to be translated to the publicly available app marketplace. This unmet need of digital mood management underscores the need for a comprehensive evaluation system of mental health apps, which we have endeavored to provide through our framework and accompanying database (apps.digitalpsych.org).
Modulation of the TGF-β signaling pathway by long noncoding RNA in hepatocellular carcinoma
Authors: Han Mengzhen , Liao Zhibin , Liu Furong , Chen Xiaoping , Zhang Bixiang
Published: December 2020

Hepatocellular carcinoma (HCC) is a type of liver cancer with poor prognosis. There have been demonstrated to exist many possible mechanisms in HCC tumorigenesis, and recent investigations have provided some promising therapy targets. However, further mechanisms remain to be researched to improve the therapeutic strategy and diagnosis of HCC. Transforming growth factor-β (TGF-β) is a pleiotropic cytokine which plays critical roles in networks of different cellular processes, and TGF-β signaling has been found to participate in tumor initiation and development of HCC in recent years. Moreover, among the molecules and signaling pathways, researchers paid more attention to lncRNAs (long non-coding RNAs), but the connection between lncRNAs and TGF-βremain poorly understood. In this review, we conclude the malignant procedure which lncRNAs and TGF-β involved in, and summarize the mechanisms of lncRNAs and TGF-βin HCC initiation and development. Furthermore, the interaction between lncRNA and TGF-β are paid more attention, and the potential therapy targets are mentioned.
Cerebral organoids: emerging ex vivo humanoid models of glioblastoma
Authors: Papaioannou Michail-Dimitrios , Sangster Kevin , Sajid Rifat Shahriar , Djuric Ugljesa , Diamandis Phedias
Published: December 2020

Glioblastoma is an aggressive form of brain cancer that has seen only marginal improvements in its bleak survival outlook of 12–15 months over the last forty years. There is therefore an urgent need for the development of advanced drug screening platforms and systems that can better recapitulate glioblastoma’s infiltrative biology, a process largely responsible for its relentless propensity for recurrence and progression. Recent advances in stem cell biology have allowed the generation of artificial tridimensional brain-like tissue termed cerebral organoids. In addition to their potential to model brain development, these reagents are providing much needed synthetic humanoid scaffolds to model glioblastoma’s infiltrative capacity in a faithful and scalable manner. Here, we highlight and review the early breakthroughs in this growing field and discuss its potential future role for glioblastoma research.
Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation
Authors: Wojtas Aleksandra M. , Carlomagno Yari , Sens Jonathon P. , Kang Silvia S. , Jensen Tanner D. , Kurti Aishe , Baker Kelsey E. , Berry Taylor J. , Phillips Virginia R. , Castanedes Monica Casey , Awan Ayesha , DeTure Michael , De Castro Cristhoper H. Fernandez , Librero Ariston L. , Yue Mei , Daughrity Lillian , Jansen-West Karen R. , Cook Casey N. , Dickson Dennis W. , Petrucelli Leonard , Fryer John D.
Published: December 2020

The molecular chaperone Clusterin (CLU) impacts the amyloid pathway in Alzheimer’s disease (AD) but its role in tau pathology is unknown. We observed CLU co-localization with tau aggregates in AD and primary tauopathies and CLU levels were upregulated in response to tau accumulation. To further elucidate the effect of CLU on tau pathology, we utilized a gene delivery approach in CLU knock-out (CLU KO) mice to drive expression of tau bearing the P301L mutation. We found that loss of CLU was associated with exacerbated tau pathology and anxiety-like behaviors in our mouse model of tauopathy. Additionally, we found that CLU dramatically inhibited tau fibrilization using an in vitro assay. Together, these results demonstrate that CLU plays a major role in both amyloid and tau pathologies in AD.
An isolated Posterolateral corner injury with rotational instability and hypermobile lateral meniscus: a novel entity
Authors: Goto Kazumi , Duthon Victoria , Menetrey Jacques
Published: December 2020

Purpose

Although complete tear of the knee posterolateral corner (PLC) commonly occurs in combination with other knee ligamentous injuries, the incidence of isolated PLC injury was reported only 28% and overlooked in many cases. Nevertheless, an isolated PLC injury does not only provoke posterolateral instability, but also may be associated to hypermobile lateral meniscus. This study aims at showing the characteristics of isolated PLC injuries and to alert potential overlooked cases by describing their arthroscopic findings and clinical characteristics.

Methods

Seventy-one patients with a clinically proven isolated PLC injury who underwent knee arthroscopy were included in this study. Pre-operative symptoms and clinical signs at examination were recorded: Pain at the posterolateral aspect, feelings of instability, catching, locking; and for clinical signs: McMurray test, varus stress test in extension and at 30° of flexion, posterolateral drawer test at 30° and 80°, dial test at 30° and 80° of flexion. In terms of arthroscopic findings, systematic meniscal stability was performed to evaluate the presence of hypermobile lateral meniscus, “lateral drive through test” was also recorded in all cases.

Results

Positive Lateral Drive through test was found in 69 patients (95.8%). Hypermobile lateral meniscus was seen in all patients.

Conclusions

Hyper mobile lateral meniscus was concomitant with all isolated PLC injuries in our case series. As the typical arthroscopic characteristic, lateral drive through test positive were seen in 95.8%. In order to prevent overlooking this concomitant pathology, meticulous arthroscopic observation is crucial.

Level of evidence

Level IV.
Functional and aesthetic outcomes of spreader graft and auto-spreader flap after nasal hump removal
Authors: Naguib Maged Baher , Ahmed Mohamed Rifaat , Madian Yasser Taha , Elnahriry Tarek Mohamady , Eldeeb Wael Elshahat
Published: December 2020

Background

Following the reduction of the nasal hump to a desired level, spreader grafts are usually positioned to prevent the complication of nasal valve collapse. Auto-spreader flap is a new technique that gained more popularity recently and can be used as an alternative to spreader graft. This RCCT compared between both techniques aesthetically and functionally as well as the operative time.

Results

Forty patients, 17 males (42.5%) and 23 females (57.5%), were included. The mean duration of operation in auto-spreader flap was 11.8 ± 3.4 min, while it was 19.2 ± 3.2 min in spreader graft. The difference between the two procedures was statistically significant (P < 0.05). Functional assessment of nasal obstruction was done for all patients in both groups preoperative that was (75.6 ± 19.9) which showed marked improvement when re-evaluated 3 moths postoperatively (18.9 ± 14.7), and after 6 months NOSE scale was (29.1 ± 20.2). The overall aesthetic satisfaction was 62.5% (25 of 40) irrespective of the surgery done. Sixteen out of 20 patients in spreader group and 9 out of 20 in auto-spreader flap group.

Conclusion

Auto-spreader flap and spreader graft are very effective surgical procedure for treatment of nasal obstruction due to internal nasal valve dysfunction, but the auto-spreader flap had shorter operative time. However, spreader graft has a superior aesthetic outcome.
A Pilot Study Evaluating the Effects of Magtrace® for Sentinel Node Biopsy in Breast Cancer Patients Regarding Care Process Optimization, Reimbursement, Surgical Time, and Patient Comfort Compared With Standard Technetium99
Authors: Shams Sina , Lippold Kai , Blohmer Jens Uwe , Röhle Robert , Kühn Friedrich , Karsten Maria Margarete
Published: December 2020

Background

Sentinel lymph node biopsy after technetium-99 (Tc99) localization is a mainstay of oncologic breast surgery. The timing of Tc99 injection can complicate operating room schedules, which can cause increasing overall costs of care and patient discomfort.

Methods

This study compared 59 patients who underwent breast cancer surgery including sentinel lymph node biopsy. Based on the surgeon’s choice, 29 patients were treated with Tc99, and 30 patients received the iron-based tracer, Magtrace. The primary outcomes were time spent on the care pathway and operating time from commissioning of the probe to removal of the sentinel node. The secondary outcomes were patient pain levels and reimbursement.

Results

The mean time spent on the preoperative breast cancer care pathway was significantly shorter for the Magtrace group (5.4 ± 1.3 min) than for the Tc99 group (82 ± 20 min) (p < 0.0001). The median time from probe usage to sentinel node extirpation was slightly but not significantly shorter in the Magtrace group (5 min; interquartile range [IQR], 3–15 min vs 10 min; IQR, 7–15 min; p = 0.151). Reimbursement and pain levels remained unchanged, and the hospital length of stay was similar in the two groups (Magtrace: 5.1 ± 2.3 days vs Tc99: 4.5 ± 3.2 days).

Conclusions

Magtrace localization shortened the preoperative care pathway and did not affect surgical time or reimbursement. Once established, it could allow for cost reduction and improve patient comfort.
Músicos ante los tribunales civiles y religiosos (siglos XVII-XVIII).
Authors: Bejarano Pellicer Clara
Published: December 2020

La sociedad barroca vivió un clima de irritabilidad notable, explicado por las circunstancias, por muy diversas razones, que afectó a todos sus integrantes. Los músicos, conocidos por su temperamento conflictivo, también protagonizaron muchos incidentes, aunque en una proporción mínima desembocaron en los tribunales de justicia. Este trabajo se propone analizar una muestra de pleitos civiles y religiosos que afectaron a músicos del mundo hispánico en los siglos XVII y XVIII, con el objetivo de distinguir las causas que les movían y perjudicaban en mayor medida o aquellas faltas que la sociedad barroca consideraba imperdonables en los músicos. Esto revelará si efectivamente la mala fama de este grupo socioprofesional está basada en una realidad contrastable. Esto ofrece interés con vistas al estudio de la profesión musical en el Barroco hispánico y
asimismo de la conflictividad social propia de entonces.
Doña Mariana Venegas, dama noble y terrateniente: compra de bienes moriscos en la Vega de Granada (1566-1594).
Authors: García Luján José Antonio
Published: December 2020

A partir de documentación de los archivos de protocolos notariales y de la Real Chancillería de Granada se delinea la biografía de la matriarca de la familia Hinojosa Granada, rama por vía femenina de la ilustre estirpe Granada Venegas, y se analiza el importante patrimonio rústico que adquirió, en régimen de gananciales, en seis pagos agrícolas de la Vega de Granada, aledaños a la ciudad. Heredad integrada por 224 fincas −hazas, huertas y olivares− con más de 1.500 marjales de tierra, compradas una parte a moriscos antes de 1570, y la mayoría a la Real Hacienda en subasta pública de bienes moriegos confiscados y vendidos −ramo de censos sueltos− a lo largo de tres décadas. Un ejemplo representativo de la actuación de la oligarquía granadina para hacerse con la posesión de estos bienes requisados. Asimismo, se detallan las rentas que generaban a finales del siglo XVI, se amplía la nómina de moriscos expulsos o que permanecieron, y se
considera el paisaje agrario a partir de la información que proporciona esta gran
propiedad.
Without fear of failure
Authors: Beere Jackie
Published: December 2020

What gets in the way of ‘fearless learning’ is the cognitive bias that creates beliefs about our limitations and abilities. Staying true to the principle of the ‘unique child’ as children progress through school is a way to empower their learning and fulfilment.
SEWAGE PHOSPHORUS REMOVAL USING HEN EGGSHELLS THROUGH DIFFERENT CONTACT SYSTEMS
Authors: Siqueira Juliano Curi de , Matos Mateus Pimentel de , Ribeiro Ivan Célio Andrade , Fia Ronaldo , Matos Antonio Teixeira de
Published: December 2020

Hen eggshell is a waste with high phosphorus (P) removal capacity from synthetic solutions. However, there is a lack of knowledge about how to use this material on P removal from real wastewater. The present study proposed to evaluate two types of system for P removal from wastewater using eggshells. On the first system, eggshells grinded, sieved in 0.425 mm, and contained in coffee filters, were fixed to baffles using calico cloth bags. On the second, the eggshells in the same conditions were attached to vertical wooden rods and distributed at different heights. For both systems, P concentration was daily monitored for four weeks, with and without medium acidification and hydraulic retention time of one day. The baffles system was more efficient, reaching a maximum removal of 15.93% in wastewater with pH 4.73. P removals did not differ significantly over the weeks; however, there is a tendency to vary the efficiencies according to the change in pH. The baffled tank, for presenting higher performance in P removal, is the most suitable for use in a domestic wastewater treatment system.
Double-loop control and intelligent parameter tuning for the temperature control system of a DBR semiconductor laser
Authors: Li Xiufei , Wang Zhuo , Chen Wei , Ning Xiaolin , Quan Wei , Zhai Yueyang
Published: December 2020

Aiming at lower startup power consumption, stronger thermal load adaptability, easier parameters adjustment, and higher parameter tuning efficiency for the temperature control system of a distributed Bragg reflector (DBR) semiconductor laser, this paper employs the double-loop control and intelligent parameter tuning methods. First, the thermal equivalent circuit model is established for the laser temperature control system, which has stronger thermal load adaptability than the traditional transfer function model. In order to improve the modeling speed and accuracy, a mean impact value (MIV) quantum particle swarm optimization (QPSO) intelligent algorithm is proposed to tune the model parameters. A double-loop temperature control system is set up on this basis. Then, the MIV-QPSO intelligent algorithm is used to tune the control parameters, which shortens the settling time, increases the tuning efficiency, and improves the temperature control effect. The feasibility and effectiveness of the proposed methods are verified through the MATLAB/Simulink simulation of the laser temperature control process.
Medical image encryption based on biometric keys and lower–upper decomposition with partial pivoting
Authors: Wang Xiaohui , Zhu Zheng , Wang Fan , Ni Renjie , Wang Jun , Hu Yuhen
Published: December 2020

The security of medical image transmission in telemedicine is very important to patients’ privacy and health. A new asymmetric medical image encryption scheme is proposed. The medical image is encrypted by two spiral phase masks (SPM) and the lower–upper decomposition with partial pivoting, where the SPM is generated from the iris, chaotic random phase mask, and amplitude truncated spiral phase transformation. The proposed scheme has the following advantages: First, the iris is used for medical image encryption, which improves the security of the encryption scheme. Second, the combination of asymmetric optical encryption and three-dimensional Lorenz chaos improves the key space and solves the linear problem based on double-random phase encoding. Third, compared with other encryption schemes, the proposed scheme has advantages in occlusion attacks, key space, correlation, and information entropy. Numerical simulation and optical results verify the feasibility and robustness of the encryption scheme.
Numerical simulation and experiment on generation dynamics of a Ho3+-doped fiber laser with an intracavity Mach–Zehnder modulator
Authors: Fedoseev Anatolii I. , Filatova Serafima A. , Kamynin Vladimir A. , Kopyeva Mariya S. , Nanii Oleg E. , Smirnov Alexander P. , Tsvetkov Vladimir B.
Published: December 2020

We present the numerical simulation and experimental results on generation dynamics of an all-fiber holmium laser with an intracavity modulator based on a Mach–Zehnder interferometer. The experimental data were compared with numerical simulation results in a wide range of parameters. An explanation for the observed increase in the pulse repetition rate from 5.8 to 11.6 kHz, as well as the transition to the chaotic pulsations mode, was given. A numerical variation of the unknown or difficult-to-measure losses in the experiment was carried out. The obtained set of parameters allowed us to implement the correct numerical optimization of an active medium and cavity. As a result, the peak powers of about 9.5 and 13 W were obtained during the experiments, as well as in the numerical simulation.
Effects of nurses’ shiftwork characteristics and aspects of private life on work-life conflict
Authors: Oh Hye-Kyung , Cho Sung-Hyun
Published: December 2020

Background

As nurses work highly irregular hours, the characteristics of shiftwork and aspects of their private lives are important factors that may contribute significantly to work-life conflict.

Purpose

This study examined the effects of nurses’ shiftwork characteristics and aspects of their private lives on work-life conflict.

Methods

The participants included 271 registered nurses working three-shift rotations in five types of units at four hospitals in South Korea. We distributed structured questionnaires regarding shiftwork characteristics, private life, and work-life conflict. Data were analyzed using multiple linear regression analysis.

Results

The significant factors relating to work-life conflict included control over shift start and finish times (β = -0.16, p = .019), frequency of swapping shifts with colleagues (β = 0.15, p = .025) among shiftwork characteristics, and leisure constraints (β = 0.39, p = < .001) in aspects of private life.

Conclusion

Plan and policies for improving nursing environments should focus on improving nurses’ control over shiftwork and decreasing leisure constraints.
Core warming of coronavirus disease 2019 (COVID-19) patients undergoing mechanical ventilation—A protocol for a randomized controlled pilot study
Authors: Bonfanti Nathaniel , Gundert Emily , Drewry Anne M. , Goff Kristina , Bedimo Roger , Kulstad Erik
Published: December 2020

Background

Coronavirus disease 2019 (COVID-19), caused by the virus SARS-CoV-2, is spreading rapidly across the globe, with little proven effective therapy. Fever is seen in most cases of COVID-19, at least at the initial stages of illness. Although fever is typically treated (with antipyretics or directly with ice or other mechanical means), increasing data suggest that fever is a protective adaptive response that facilitates recovery from infectious illness.

Objective

To describe a randomized controlled pilot study of core warming patients with COVID-19 undergoing mechanical ventilation.

Methods

This prospective single-site randomized controlled pilot study will enroll 20 patients undergoing mechanical ventilation for respiratory failure due to COVID-19. Patients will be randomized 1:1 to standard-of-care or to receive core warming via an esophageal heat exchanger commonly utilized in critical care and surgical patients. The primary outcome is patient viral load measured by lower respiratory tract sample. Secondary outcomes include severity of acute respiratory distress syndrome (as measured by PaO2/FiO2 ratio) 24, 48, and 72 hours after initiation of treatment, hospital and intensive care unit length of stay, duration of mechanical ventilation, and 30-day mortality.

Results

Resulting data will provide effect size estimates to guide a definitive multi-center randomized clinical trial. ClinicalTrials.gov registration number: NCT04426344.

Conclusions

With growing data to support clinical benefits of elevated temperature in infectious illness, this study will provide data to guide further understanding of the role of active temperature management in COVID-19 treatment and provide effect size estimates to power larger studies.
Documentary games for social change: Recasting violence in the latest generation of i-docs
Authors: Dowling David O.
Published: December 2020

The evolutionary trajectory of digital journalism has been fuelled by the convergence of visual storytelling unique to documentary filmmaking with the graphics and procedural rhetoric of digital games. The reciprocal influences between gaming and documentary forms coalesce in this new highly engaging interactive journalism. This research demonstrates how game mechanics, design and logics combine with cinematic storytelling conventions in documentary games published since 2014. As forms of civic engagement more intimate and immersive than traditional print and broadcast journalism, documentary games leverage alternative depictions of violence for social critique. Case studies examine products of independent developers including the documentary games We Are Chicago by Culture Shock Games and iNK Stories’ 1979 Revolution: Black Friday along with its related vérité virtual reality experience, Blindfold. These cases represent major advances in the activist depiction of oppressed populations in narrative documentary journalism. All these projects feature atypical video game protagonists anathema to those of mainstream games.
Estereotipos de género y ciberbullying en las series de ficción adolescentes: un análisis comparativo de Gossip Girl, Pretty Little Liars y Get Even
Authors: Morejón Llamas Noemí
Published: December 2020

Las series de ficción dirigidas a adolescentes actúan como importantes agentes socializadores en un mundo cada vez más individualizado y complejo a consecuencia de las nuevas tecnologías y las nuevas dinámicas de visualización. Los estereotipos femeninos representados en ellas tienen el poder de reconfigurar la construcción identitaria de los telespectadores, que asumirán determinados roles y los aplicarán a su realidad. Este trabajo identifica un cambio lento y superficial en la representación estereotipada de la mujer en las series dirigidas a adultos y pretende dilucidar si ocurre lo mismo en los seriales adolescentes. El objetivo de esta investigación pretende examinar a sus protagonistas, analizar las tramas y demostrar si estamos ante una modificación estructural de dichos roles de género en series que abordan el ciberbullying y sus dinámicas de acoso en los dramas de instituto. Para ello analizaremos las series Gossip Girl, Pretty Little Liars y Get Even a través de un análisis cualitativo fundamentado en el Análisis de contenido y el Análisis crítico del discurso.
Experiencia perceptiva y falsos planos subjetivos en El eclipse (Michelangelo Antonioni, 1962) y Muerte en Venecia (Luchino Visconti, 1971)
Authors: Aertsen Víctor
Published: December 2020

Los planos subjetivos son un recurso poderoso cuando aparecen en su estructura canónica, pero también presentan un gran potencial estético cuando esta se altera para romper las expectativas del espectador. Por ejemplo, en los casos de “falso plano subjetivo” en los que el espectador se enfrenta a la necesidad de reevaluar la condición subjetiva del plano que observa al aparecer en el mismo el personaje con el que creía estar compartiendo la mirada. Todos los falsos planos subjetivos producen experiencias que comparten ciertas cualidades fenomenológicas por el modo en que actúan sobre las expectativas y la percepción del espectador. Este artículo reflexiona en torno a cuatro de estos efectos, describiendo su alcance general y profundizando en sus posibilidades expresivas a partir del análisis de sendas escenas de El eclipse (Michelangelo Antonioni, 1962) y Muerte en Venecia (Luchino Visconti, 1971).
La televisión como testigo de los cambios sociales
Authors: Zapatero Flórez Cristina
Published: December 2020

Reseña de Histoire sociale de la télévision en España
The Geographic, Environmental and Phylogenetic Evolution of the Alveolinoidea from the Cretaceous to the Present Day.
Authors: Boudagher-Fadel Marcelle , Price Geoffrey David
Published: December 2020

The superfamily Alveolinoidea is a member of the Order Miliolida, and is comprised of three main families, the Alveolinidae, the Fabulariidae and the Rhapydioninidae. They are examples of Larger Benthic Foraminifera (LBF), which are single cell organisms with specific characteristic endoskeletons. Alveolinoids are found globally from the Cretaceous to present day and are very important biostratigraphic index fossils in shallow-marine carbonates. They are often associated with significant hydrocarbon reservoirs, and exhibit provincialism with characteristic genera often confined to one of the American, Tethyan or Indo-Pacific provinces. Previously, the systematic study of the global interrelationship between the various alveolinoid lineages has not been possible because of the absence of biostratigraphic correlation between the geographically scattered assemblages, and the scarcity of described material from the Indo-Pacific province. Here we use the literature and new material from the Americas, the French Alps, Iran, Tibet, India and SE Asia, coupled with the use the planktonic foraminiferal zonal (PZ) correlation scheme to put forward, for the very first time, a comprehensive, global, systematic analysis of the biostratigraphic, phylogenetic and palaeogeographic evolution of the alveolinoids. The alveolinoids originated in the Cretaceous in the Tethyan province. During a global sea-level low-stand, a westward migration of some alveolinoids species to the Americas occurred in this period, a behaviour also seen in previous studies of contemporaneous orbitolinid LBF. After the K-P event, which saw the extinction of all Cretaceous alveolinoids, rare new forms of alveolinoids evolved again, first in the Americas and later independently in Tethys. As found in previous studies of rotalid LBF, sea-level low-stands in the Paleocene also allowed some alveolinoid forms to migrate, but this time in an eastward direction from the Americas to Tethys, and from Tethys on to the Indo-Pacific. Alveolinoids still exist today (
Borelis and
Alveolinella), the former of which is cosmopolitan, while the latter is restricted to the Indo-Pacific province. Throughout their phylogenetic history alveolinoids characteristically exhibit convergent evolution, with the repeated re-occurrence of certain morphological features. Understanding this propensity to homoplasy is essential in understanding and constructing the phylogenetic relationships within the alveolinoid superfamily.
TRAJETÓRIA DA INDÚSTRIA TÊXTIL EM ALAGOAS E SERGIPE: ENTRE O DECLÍNIO E A MODERNIZAÇÃO
Authors: Gonçalves da Silva Bruno Bianchi , Corrêa Domingos Sávio
Published: December 2020

De forte tradição têxtil, os estados de Alagoas e Sergipe apresentam realidades opostas sobretudo a partir dos anos 2000. Alagoas enfrentou o declínio de seu parque têxtil nas décadas recentes ao passo que Sergipe se reestruturou neste setor. Assim, a pesquisa tem por objetivo identificar os principais fatores do declínio do parque têxtil alagoano, à medida que, em Sergipe ocorre a reestruturação do parque têxtil, e considerar as motivações na instalação de fábricas têxteis em determinadas cidades sergipanas. A escolha em estudar ambos os estados sob a perspectiva têxtil não foi aleatória. Trata-se de estados vizinhos com porte socioeconômico semelhante e um processo histórico que permite algumas aproximações. Analisando em perspectiva histórica, o início do século XXI marca o recorte temporal da pesquisa. Por se tratar de um setor industrial complexo a pesquisa se detêm as fábricas têxteis de fiação e tecelagem, não descartando empresas verticalmente integradas, isto é, que integram as etapas produtivas de beneficiamento das fibras à produção de determinado artigo têxtil. Constata-se que o desinteresse da elite política alagoana pela indústria têxtil e a resistência a modernização condicionou o declínio do parque têxtil e inviabilizou a atração de novas empresas do setor.
GROUNDWATER QUALITY OF THE GUARANI (GAIS) AND SERRA GERAL (SGAIS) AQUIFER INTEGRATED SYSTEM IN WESTERN SANTA CATARINA, BRAZIL
Authors: Facco Janete , Luiz  Carasek Fabio , Francisco de Oliveira Junior Sival , Gazzoni dos Passos Manuela
Published: December 2020

The objective of this work was to evaluate the groundwater quality of the Guarani/Serra Geral Integrated Aquifer System (GAIS / SGAIS) in a region located in the western part of the state of Santa Catarina. A total of 105 water wells were selected which five are exploring water from the Guarani Aquifer and 100 from the Serra Geral Aquifer. A sample of each well was submitted to microbiological (total coliforms and Escherichia coli) and physicochemical analyzes (dissolved oxygen, pH, turbidity, electrical conductivity, alkalinity, chlorides, fluorine, sulfates, potassium, sodium, calcium, magnesium, iron, manganese, nitrate). For analyze possible contamination by BTEX hydrocarbons (benzene, toluene, ethyl benzene, xylenes) the water of 25 wells in the urban environment was analyzed in strategic points close to possible risk of risk contamination agents. In another 25 wells in the rural area the water was collected for analyze the presence of glyphosate. Some groundwater with turbidity, pH, iron, manganese, total and thermotolerant coliforms were found in disagreement with Ministry of Health Ordinance 2914/2011. Furthermore, there was no BTEX and glyphosate contamination detected in any of the wells.
A QUESTÃO HÍDRICA E A DINÂMICA DE CONSUMO DE ÁGUA PARA ABASTECIMENTO DOMÉSTICO NA CIDADE DE ITUIUTABA - MG
Authors: Penna Maria Cristina Moreira , Costa Rildo Aparecido
Published: December 2020

A importância da conservação da água como recurso natural em face aos problemas hídricos enfrentados nas cidades atualmente e a necessidade de se manter a qualidade e disponibilidade hídrica para o consumo humano, motivaram essa pesquisa. O objetivo dessa pesquisa foi compreender a disponibilidade hídrica e a dinâmica de consumo da água para o abastecimento doméstico. Para se compreender a disponibilidade hídrica do município utilizou-se a metodologia do Balanço Hídrico proposto por Thornthwaite e Mather (1955), além dos dados climáticos fornecidas pela Estação Automática de Ituiutaba – MG (1998 a 2018), pertencente ao Instituto Nacional de Meteorologia (INMET). Foi utilizado também, a metodologia de anos-padrão (Tavares 1976). A análise final dos dados avalia a qualidade e disponibilidade hídrica como satisfatórias para atender o abastecimento doméstico. Porém, o consumo de água elevado em períodos críticos de recarga de água nas bacias hidrográficas alerta para a necessidade do uso racional de modo que a demanda não torne a disponibilidade insuficiente futuramente. Quanto à qualidade hídrica, a SAE tem mostrado eficiência nos serviços prestados e, para manter esses resultados, depende também da colaboração da população e de políticas públicas em relação ao seu uso e ocupação.
Cálculo de la elongación, dilatación y vectores de rotación de la deformación con algunas estaciones GPS en Colombia
Authors: González Parra Camilo Andrés , Puente Robinson Quintana , Montes Vide Luis
Published: December 2020

La actividad sísmica que tiene Colombia, en especial Bogotá D.C., es alta por estar en una zona geológica muy activa. El documento es una investigación que muestra el cálculo de elongación, vectores de rotación y dilatación, combinando metodologías computacionales y ecuaciones de geología estructural; para ello, se usan las coordenadas y vectores de velocidad de las estaciones permanentes que pertenecen a la red del Sistema de Referencia Geocéntrico para las Américas. El área de estudio está delimitada por 37 estaciones permanentes ubicadas en el territorio colombiano, para calcular estas variables se usó la metodología del vecino más cercano y las ecuaciones de tensor de deformación y tensor de desplazamiento. Estas ecuaciones fueron programadas en el software Matlab debido a su destreza para trabajar en la solución de matrices, el resultado final de estos cálculos muestra que la zona de estudio se está desplazando en sentido nororiente, se deforma un máximo de , la precisión se debe al uso de datos de Sistema de Posicionamiento Global.
SOME RESULT OF NON-COPRIME GRAPH OF INTEGERS MODULO n GROUP FOR n A PRIME POWER
Authors: Masriani Masriani , Juliana Rina , Syarifudin Abdul Gazir , Wardhana I Gede Adhitya Wisnu , Irwansyah Irwansyah , Switrayni Ni Wayan
Published: December 2020

One interesting topic in algebra and graph theory is a graph representation of a group, especially the representation of a group using a non-coprime graph.  In this paper, we describe the non-coprime graph of integers modulo  group and its subgroups, for  is a prime power or  is a product of two distinct primes.
Tinjauan Nilai Manfaat pada Pengelolaan Sampah Plastik Oleh Sektor Informal (Studi Kasus: Kecamatan Purwodadi, Kabupaten Grobogan)
Authors: Kustanti Ratna , Rezagama Arya , Ramadan Bimastyaji Surya , Sumiyati Sri , Samadikun Budi Prasetyo , Hadiwidodo Mochtar
Published: December 2020

Penggunaan kembali material limbah dengan cara mendaur ulang merupakan salah satu cara efektif untuk menghindari pencemaran lingkungan dan mengurangi volume timbulannya di Tempat Pembuangan Akhir. Penelitian ini dilakukan untuk mengetahui potensi ekonomi kegiatan daur ulang sampah plastik oleh sektor informal di Kecamatan Purwodadi. Penelitian dilakukan melalui survei menggunakan kuesioner terhadap 29 pelaku daur ulang. Hasil penelitian menunjukkan bahwa potensi ekonomi yang terdapat dalam usaha daur ulang sampah plastik pada tiap tingkatan pelaku daur ulang berbeda-beda. Berdasarkan analisis kelayakan ekonomi menggunakan  nilai Net Present Value (NPV), Benefit Cost Ratio (BCR),  dan  Internal Rate of Return (IRR) dapat disimpulkan bahwa usaha daur ulang tingkat penggiling layak secara ekonomi dengan nilai NPV Rp 923.395.260  (NPV > 1), nilai BCR 1,58 (BCR > 1), dan nilai IRR 56,82. Benefit (manfaat) dari implementasi program 3R sampah plastik pada sektor informal secara umum dapat digolongkan menjadi dua manfaat, yaitu manfaat langsung (direct benefit) dan manfaat tidak langsung (indirect benefit). Manfaat langsung (direct benefit) berupa keuntungan penjualan sampah plastik. Keuntungan bersih tiap jenis sampah plastik pada tingkat pemulung  antara Rp 500-Rp 2.600, tingkat bank sampah berkisar antara Rp 100-Rp 400, tingkat pengepul I berkisar antara Rp 91,67-Rp 391,67, tingkat pengepul II berkisar antara Rp 173,46-Rp 473,46, tingkat bandar berkisar antara Rp 186,94-Rp 686,94, dan tingkat penggiling berkisar antara Rp 136,23-Rp 1.136,32. Manfaat tidak langsung (indirect benefit) adanya pengelolaan sampah plastik oleh sektor informal yaitu tereduksinya sampah plastik di Kecamatan Purwodadi sebesar 10,08%.
PENGARUH TINGKAT KEPADATAN TELUR YANG BERBEDA TERHADAP EMBRIOGENESIS, LAMA WAKTU PENETASAN DAN DERAJAT PENETASAN TELUR IKAN TAWES (Barbonymus gonionotus)
Authors: Alfath Ziadah , Basuki Fajar , Nugroho Ristiawan Agung
Published: December 2020

Proses penetasan telur merupakan salah satu fase yang menentukan keberhasilan budidaya ikan. Daya tetas telur yang tinggi dengan kualitas telur yang baik akan menjadikan produksi larva tawes dengan kualitas yang baik. Permasalahan dari produksi dalam budidaya ikan tawes hanya mampu menghasilkan telur sebanyak 10.000 dengan daya tetas yang rendah yaitu sebesar 22%. Sebagai upaya peningkatan derajat penetasan telur ikan tawes yaitu dengan perlakuan tingkat kepadatan yang berbeda pada setiap wadah penetasan. Penelitian ini bertujuan untuk mengetahui pengaruh tingkat kepadatan yang berbeda terhadap perkembangan telur dan derajat penetasan telur ikan tawes (B.gonionotus), untuk mengetahui kepadatan yang optimal bagi penetasan telur ikan tawes. Penelitian dilaksanakan Satuan Kerja Perbenihan dan Budidaya Ikan Air Tawar (PBIAT) Ngrajek, Magelang, Jawa Tengah pada Bulan Maret-April 2018. Bahan uji yang digunakan adalah telur ikan tawes (B.gonionotus) hasil pemijahan di Balai. Penelitian ini menggunakan metode eksperimental dengan Rancangan Acak Lengkap (RAL) terdiri atas 4 perlakuan dengan 3 kali ulangan yakni, kepadatan dalam 10 liter air A (10 butir/liter air), B (20 butir/liter air), C (30 butir/liter air), D (40 butir/liter air). Variabel yang diukur meliputi: Pengamatan perkembangan telur secara deskriptif, waktu penetasan (menit), derajat penetasan (HR) dan kualitas air. Data derajat penetasan dianalisis dengan analisis ragam, apabila berpengaruh maka dilakukan uji wilayah ganda Duncan untuk mengetahui beda antar perlakuan untuk menentukan perlakuan terbaik. Hasil penelitian menunjukkan bahwa tingkat kepadatan yang berbeda berpengaruh nyata (F hitung > F tabel) terhadap parameter uji. Hasil perkembangan embrio tercepat diperoleh perlakuan C dan D secara bersamaan, derajat penetasan tertinggi diperoleh perlakuan B yaitu sebesar 89,83±3,55.
Novel GLP-1 analog supaglutide improves glucose homeostasis in diabetic monkeys
Authors: Cui Qiaoli , Liao Yijing , Jiang Yaojing , Huang Xiaohang , Tao Weihong , Zhou Quanquan , Shao Anna , Zhao Ying , Li Jia , Ma Anran , Wang Zhihong , Zhang Li , Yang Zunyuan , Liang Yinan , Wu Minglin , Yang Zhenyan , Zeng Wen , Wang Qinghua
Published: December 2020

Glucagon-like peptide 1 (GLP-1) is an insulinotropic hormone and plays an important role in regulating glucose homeostasis. GLP-1 has a short half-life (t1/2 < 2 min) due to degrading enzyme dipeptidyl peptidase-IV and rapid kidney clearance, which limits its clinical application as a therapeutic reagent. We demonstrated recently that supaglutide, a novel GLP-1 mimetic generated by recombinant fusion protein techniques, exerted hypoglycemic and β-cell trophic effects in type 2 diabetes db/db mice. In the present study, we examined supaglutide’s therapeutic efficacy and pharmacokinetics in diabetic rhesus monkeys. We found that a single subcutaneous injection of supaglutide of tested doses transiently and significantly reduced blood glucose levels in a dose-dependent fashion in the diabetic monkeys. During a 4-week intervention period, treatment of supaglutide of weekly dosing dose-dependently decreased fasting and random blood glucose levels. This was associated with significantly declined plasma fructosamine levels. The repeated administration of supaglutide remarkably also decreased body weight in a dose-dependent fashion accompanied by decreased food intake. Intravenous glucose tolerance test results showed that supaglutide improved glucose tolerance. The intervention also showed enhanced glucose-stimulated insulin secretion and improved lipid profile in diabetic rhesus monkeys. These results reveal that supaglutide exerts beneficial effects in regulating blood glucose and lipid homeostasis in diabetic rhesus monkeys.