bluuebunny/crossref_metadata_2025 huggingface dataset:
Cost-effectiveness analysis of bevacizumab combined with lomustine in the treatment of progressive glioblastoma using a Markov model simulation analysis
Authors: Chen Zhaoyan , Tian Fangyuan , Zhang Ying
Published: May 2024

Background

Progressive glioblastoma (GBM) is a malignancy with extremely poor prognosis. Chemotherapy is one of the approved systemic treatment modalities. The aim of this study is to assess the cost-effectiveness of using bevacizumab (BEV) in combination with lomustine (LOM) regimen for the treatment of progressive glioblastoma in China.

Methods

The estimation results are derived from a multicenter randomized phase III trial, which demonstrated improved survival in GBM patients receiving BEV+LOM combination therapy. To calculate the incremental cost-effectiveness ratio (ICER) from the perspective of Chinese society, a Markov model was established. Univariate deterministic analysis and probabilistic sensitivity analysis were employed to address the uncertainties within the model.

Results

Compared to LOM monotherapy, the total treatment cost for BEV+LOM combination therapy increased from $2,646.70 to $23,650.98. The health-adjusted life years (QALYs) for BEV+LOM combination therapy increased from 0.26 QALYs to 0.51 QALYs, representing an increment of 0.25 QALYs. The incremental cost-effectiveness ratio (ICER) was $84,071.12. The cost-effectiveness curve indicates that within the willingness-to-pay (WTP) range of $35,906 per QALY, BEV+LOM combination therapy is not a cost-effective treatment option for unresectable malignant pleural mesothelioma patients.

Conclusions

Taken as a whole, the findings of this study suggest that, from the perspective of payers in China, BEV+LOM combination therapy as a first-line treatment for GBM is not a cost-effective option. However, considering the survival advantages this regimen may offer for this rare disease, it may still be one of the clinical treatment options for this patient population.
Consequences of geographical accessibility to post-exposure treatment for rabies and snakebite in Africa: a mini review
Authors: Faust Aurélia , Ray Nicolas
Published: May 2024

Introduction

Rabies and snakebite envenoming are two zoonotic neglected tropical diseases (NTDs) transmitted to humans by animal bites, causing each year around 179,000 deaths and are most prevalent in Asia and Africa. Improving geographical accessibility to treatment is crucial in reducing the time from bite to treatment. This mini review aims to identify and synthesize recent studies on the consequences of distance and travel time on the victims of these diseases in African countries, in order to discuss potential joint approaches for health system strengthening targeting both diseases.

Methods

A literature review was conducted separately for each disease using Pubmed, Google Scholar, and snowball searching. Eligible studies, published between 2017 and 2022, had to discuss any aspect linked to geographical accessibility to treatments for either disease in Africa.

Results

Twenty-two articles (8 on snakebite and 14 on rabies) were eligible for data extraction. No study targeted both diseases. Identified consequences of low accessibility to treatment were classified into 6 categories: (1) Delay to treatment; (2) Outcome; (3) Financial impacts; (4) Under-reporting; (5) Compliance to treatment, and (6) Visits to traditional healers.

Discussion and conclusion

Geographical access to treatment significantly influences the burden of rabies and snakebite in Africa. In line with WHO's call for integrating approaches among NTDs, there are opportunities to model disease hotspots, assess population coverage, and optimize geographic access to care for both diseases, possibly jointly. This could enhance the management of these NTDs and contribute to achieving the global snakebite and rabies roadmaps by 2030.
Acceptance of the use of silver fluoride among Brazilian parents of children with special health care needs
Authors: Potgieter N. , Pereira V. , Elias R. , Charone S. , Groisman S.
Published: May 2024

Background

Children with special health care needs including Down Syndrome, Autism Spectrum Disorder and Down Syndrome experience difficulties in receiving dental treatment. Silver Diamine Fluoride (SDF) and Silver Fluoride (SF) are a minimally invasive treatments options to arrest dental caries without sedation; local or general anaesthesia (GA).

Aim

Evaluation of Brazilian's parents' acceptance of the use of SF in CSHCN.

Methods

After receiving education on SF, 100 Parents of CSHCN completed a questionnaire concerning their acceptance of SF, in different dental situation.

Result

Majority of parents (74,5%) agreed to the use of SF for their children. SF was more acceptable on posterior teeth (74,5%) when compared to its use on anterior teeth (43,1%). Parents accepted to use SF in order: to reduce infection and pain (82,4%); to avoid dental injection (72,5%) and treatment under GA (84,3%). The Majority of parents accepted the properties of SF (82,4%) and Silver (80,4%).

Conclusion

Silver Fluoride was accepted as a treatment option for caries, by Brazilian parents of CSHCN. SF should be considered as a treatment option for caries limited to dentine for CSHCN, taking into consideration the individual needs and opinions with regard to aesthetics and exposure to fluoride and silver.
CIEMER in action: from development to application of a co-creative, interdisciplinary exergame design process in XR
Authors: Retz Celina , Klotzbier Thomas Jürgen , Ghellal Sabiha , Schott Nadja
Published: May 2024

Introduction

Motor-cognitive learning is crucial for achieving and maintaining wellbeing. Exergames can effectively facilitate this type of learning due to their inherent qualities of exertion and game-related disciplines. These qualities can create effectiveness, enjoyment, and meaning in the lives of individuals. To address these aspects equally, the design process for exergame interventions needs to be interdisciplinary from the beginning.

Objective

This paper aims to (1) enhance an exergame design process model for interdisciplinary co-creation (CIEM) by an Extended Reflection part (CIEMER). Furthermore, it aims to (2) show a formal process for making the abstract model applicable. In doing so, (3) this paper will also derive methods for conducting the process in an academic seminar.

Methods

The study employed the CIEMER to conduct a 2-month academic seminar with 20 students. The seminar consisted of a 3-day intensive workshop, a 6-week work phase, and a 1-week testing phase, creating four Extended Reality prototypes. We used a mixed methods approach to evaluate the model, including feedback interviews with external experts, internal surveys, and written reflections from student designers.

Results

Four motor-cognitive learning prototypes in Extended Reality were created using the CIEMER. External expert evaluations highlighted the prototypes’ alignment with effective, enjoyable, and meaningful objectives and potential efficacy while noting shortcomings in discipline-specific theoretical application. Internal feedback from students, collected via surveys and reflections, consistently showed positive outcomes in interdisciplinary collaboration and learning, underscoring the importance of an integrated approach in achieving project goals.

Conclusion

The formal process within CIEMER effectively yielded four promising prototypes, demonstrating its sufficiency. Students positively acknowledged the benefits of interdisciplinary collaboration, finding it supportive and competence-enhancing. Additionally, the Extended Reflections enabled rapid and targeted iterations, streamlining the reflection of the current state and Creation process.
Do We Need Creativity in Math?
Authors: Bruhn Svenja , Nolte Marianne
Published: May 2024

When you think of creativity, what comes to your mind? Maybe you remember painting a picture, or you think of a special piece of music that you listened to or maybe even composed yourself. At some point, at least one of your teachers probably said something like “Let’s be creative!”. Then, it was up to you to decide how to work on a task. What makes creative projects truly special is that, in the end, each of your classmates creates something unique. But have you ever heard your math teacher encourage you to be creative? We guess that the answer is “No”. Why is it generally thought that creativity is so important in arts, but not in math? That is the question we are going to explore in this article. By taking a closer look at some examples of math tasks, we will describe four abilities that you need to be creative in math.
Target and science visibility of the solar-terrestrial observer for the response of the magnetosphere (STORM) global imaging mission concept
Authors: Murphy Kyle R. , Shoemaker Michael A. , Sibeck David G. , Schiff Conrad , Connor Hyunju , Porter Fredrick S. , Zesta Eftyhia
Published: May 2024

Imaging missions in Earth Science, Heliophysics, and Astrophysics have made fundamental advancements in science and have helped to further our understanding of our natural environment. Here we review the Solar-Terrestrial Observer for the Response of the Magnetosphere (STORM) mission concept, a global solar wind-magnetosphere imaging mission and investigate how often STORM can observe and image its key science targets; the magnetopause, ring current, and auroral oval. We introduce a novel analysis which defines STORM’s plasma targets as discrete sample points in space, these points are collectively called point groups. These point groups are used in conjunction with fields-of-view of STORM’s imagers to quantify target visibility, how often the mission can observe each of its targets. The target visibility is combined with a statistical investigation of historical solar wind and geomagnetic data, and a k-folds/Monte Carlo analysis to quantify STORM’s science visibility. That is how often specific targets can be observed during elevated solar wind and geomagnetic conditions such that detailed science investigations can be completed to address STORM’s science objectives. This analysis is further expanded to potential dual-spacecraft mission configurations to determine the nominal inter-orbit phasing which maximizes target and science visibility. Overall, we find that the target and science visibility of a single spacecraft mission is large, in the 100s and 1000s of hours/events, while the target and science visibility peak for a dual-spacecraft mission where the two spacecraft are ∼85○ out of phase.
Toward a sustainable agricultural system in China: exploring the nexus between agricultural science and technology innovation, agricultural resilience and fiscal policies supporting agriculture
Authors: Qun Wan , Ranran Chao , Jingsuo Li , Khan Nawab
Published: May 2024

Introduction

This study delves into the intricate dynamics between fiscal policies supporting agriculture and the non-linear influence of agricultural science and technology innovation on enhancing agricultural resilience. We conducted research across 31 provinces (including autonomous regions and municipalities) in China from 2007 to 2021.

Method

By constructing the evaluation index system of agricultural resilience, the entropy value method is used to measure the value of agricultural resilience, and then standard deviation ellipse and center of gravity migration analysis, benchmark regression model, heterogeneity analysis, threshold regression model are used to analyze the relationship between agricultural science and technology innovation, fiscal policies supporting agriculture and agricultural resilience.

Result

(1) The analysis of the spatio-temporal evolution trend shows that the overall development of China’s agricultural resilience is relatively stable, the resilience range is expanding, and the geographical area with the southeast as the center of gravity presents a stronger pulling effect; (2) The benchmark regression model shows that agricultural science and technology innovation has a significant positive effect on agricultural resilience; (3) Agricultural science and technology innovation plays a nonlinear role in increasing agricultural resilience when fiscal policies supporting agriculture are used as a threshold variable. (4) Heterogeneity analysis highlights stronger promotion of agricultural resilience through science and technology innovation in non-main producing areas and economically underdeveloped regions.

Discussion

To address this, policymakers should leverage the resilience of the Southeast, boost innovation capacity, tailor innovation to local needs, and reinforce fiscal policies supporting agriculture. These insights provide valuable direction for policymakers in crafting effective measures to enhance agricultural resilience.
Role of immunotherapy in treatment refractory chordomas: review of current evidence
Authors: Alexander A. Yohan , Dhawan Sanjay , Venteicher Andrew S.
Published: May 2024

Introduction

Chordomas are aggressive tumors that are thought to arise from remnants of the embryological notochord. They can arise along the ventromedial aspect of the sacrum, mobile spine, and clivus—with most cases occurring in the sacrum or skull base. Despite surgery and radiation, chordomas often progress and become refractory to further treatment. The high recurrence rate of chordomas has created an urgent need to develop new systemic treatment options. Recent case reports and clinical trials have highlighted the use of immunotherapy for refractory chordomas. In this review, we summarize the results of these studies and discuss the potential role of immunotherapy for chordomas.

Methods

The PUBMED database was queried for studies mentioning both “Chordoma” and “Immunotherapy.” All case series and case reports that involved administration of an immunotherapy for chordoma were included. Additional studies that were found during literature review were added. ClinicalTrials.Gov was queried for studies mentioning both “Chordoma” and “Immunotherapy.” The final cohort consisted of all clinical trials that utilized immunotherapy for chordomas of any location.

Results

Eight case reports and series detailing the use of immunotherapy for treatment refractory chordoma were identified. Most patients received immunotherapy targeting the PD-1/PD-L1 interaction, and two patients received therapy targeting this interaction along with the tyrosine kinase inhibitor pazopanib. One patient received a vaccine derived from autologous tumor cells, and one patient received a viral vector that downregulated the effect of TGF-beta. One clinical trial utilized a brachyury vaccine in conjunction with standard of care radiotherapy.

Conclusions

Immunotherapy for chordoma is a promising area of investigation with increasing, but small, numbers of case series and clinical trials. Despite challenges in patient accrual, future directions in chordoma immunotherapy may lie in vaccine-based therapies and immune checkpoint inhibitors. Understanding chordoma heterogeneity and microenvironment will likely elucidate important chordoma features that will inform future clinical trial design.
Case report: Omphalitis caused by Trueperella pyogenes infection in a Korean indigenous calf
Authors: Kim Youngjun , Ji Min-Jeong , Park Jinho , Choi Kyoung-Seong
Published: May 2024

Omphalitis, commonly caused by opportunistic bacteria has been significantly associated with morbidity and mortality in neonatal calves. Trueperella pyogenes is a commensal and opportunistic pathogen that can cause suppurative infection in farm animals. Our case involved a 10-day-old female Korean indigenous calf that presented with umbilical enlargement accompanied by a greenish-yellow purulent discharge and right forelimb lameness. The calf was diagnosed with failure of passive transfer at 24 h of age. Physical examination found hypothermia (38.1°C), tachycardia (110 beats/min), tachypnea (47 cycles/min), and open mouth breathing. Ultrasonography revealed hyperechoic pus in the 9th and 10th right intercostals, for which a liver abscess due to omphalophlebitis was suspected. After 3 days, the calf died. T. pyogenes was detected in the umbilical cord, lung, liver, kidney, intestine, mesenteric lymph node, urinary bladder, and bladder ligament. All genes related to the virulent factors (i.e., plo, cbpA, fimA, fimC, fimG, nanH, and nanP) were also identified, with plo and fimA being associated with pathogenicity. A final diagnosis of omphalitis was established based on the identification of virulent T. pyogenes and umbilical cord dilatation on ultrasonography. Antimicrobial susceptibility tests showed that the isolated T. pyogenes was susceptible to amoxicillin, ceftiofur, florfenicol, enrofloxacin, ofloxacin, and ciprofloxacin, suggesting the suitability of these antibiotics for treating T. pyogenes-induced omphalitis. Hence, accurate and rapid diagnosis of the involved bacteria and antimicrobial susceptibility patterns can help guide therapeutic decisions. Our case provides useful information that could aid large animal clinicians in the diagnosis and treatment of T. pyogenes-induced omphalitis.
Genome-wide characteristics and potential functions of circular RNAs from the embryo muscle development in Chengkou mountain chicken
Authors: Zhang Yang , Wang Haiwei , Li Xingqi , Yang Chaowu , Yu Chunlin , Cui Zhifu , Liu Anfang , Wang Qigui , Liu Lingbin
Published: May 2024

The Chengkou mountain chicken, a native Chinese poultry breed, holds significant importance in the country’s poultry sector due to its delectable meat and robust stress tolerance. Muscle growth and development are pivotal characteristics in poultry breeding, with muscle fiber development during the embryonic period crucial for determining inherent muscle growth potential. Extensive evidence indicates that non-coding RNAs (ncRNAs) play a regulatory role in muscle growth and development. Among ncRNAs, circular RNAs (circRNAs), characterized by a closed-loop structure, have been shown to modulate biological processes through the regulation of microRNAs (miRNAs). This study seeks to identify and characterize the spatiotemporal-specific expression of circRNAs during embryonic muscle development in Chengkou mountain chicken, and to construct the potential regulatory network of circRNAs-miRNA-mRNAs. The muscle fibers of HE-stained sections became more distinct, and their boundaries were more defined over time. Subsequent RNA sequencing of 12 samples from four periods generated 9,904 novel circRNAs, including 917 differentially expressed circRNAs. The weighted gene co-expression network analysis (WGCNA)-identified circRNA source genes significantly enriched pathways related to cell fraction, cell growth, and muscle fiber growth regulation. Furthermore, a competitive endogenous RNA (ceRNA) network constructed using combined data of present and previous differentially expressed circRNAs, miRNA, and mRNA revealed that several circRNA transcripts regulate MYH1D, MYH1B, CAPZA1, and PERM1 proteins. These findings provide insight into the potential pathways and mechanisms through which circRNAs regulate embryonic muscle development in poultry, a theoretical support for trait improvement in domestic chickens.
Molecular detection and phylogenetic analysis of Orf viruses from goats in Jiangxi province, China
Authors: Zhang Zhibang , Zhang Xiaoyan , Meng Ping , Feng Kang , Gong Jinxiang , Yang Ziyin , Yang Taotao , Xu Xingli , Zheng Wenya , Li Pengcheng
Published: May 2024

Orf is a zoonosis caused by the Orf virus (ORFV), which is endemic in goats, sheep, and wild ruminants worldwide. Orf infection is prevalent in China, with outbreaks reported in several provinces. Currently, there is limited information available regarding the characterization of ORFV strains in Jiangxi province. This study investigated an acute outbreak of Orf that occurred in 2021 in a goat herd in the Jiangxi province of China. Clinical signs in this case included lesions on the lips, nose, and inside the mouth. The presence of ORFV was confirmed from tissue samples by polymerase chain reaction (PCR). The nucleotide sequences of the B2L and F1L genes were fully sequenced and used to construct phylogenetic trees. The results of this investigation identified the ORFV JXxy2021 as the cause of the outbreak. The phylogenetic analysis revealed that the ORFV strain JXxy2021 had the highest similarity to the ORFV strains GO and FJ-SL from the neighboring province of Fujian. This suggests that JXxy2021 was likely transmitted from Fujian province. The results have provided valuable information on the genetic characteristics of JXxy2021 and the endemic situations of Orf in China.
The role of miR-10a-5p in LPS-induced inhibition of progesterone synthesis in goose granulosa cells by down-regulating CYP11A1
Authors: Guo Xinyi , An Hao , Guo Rihong , Dai Zichun , Ying Shijia , Wu Wenda
Published: May 2024

The poultry ovary is a preferred target for E. coli and Salmonella infection of tissues, and lipopolysaccharide (LPS) is a critical molecule in infecting the organism and interfering with cell function, invading the ovaries through the cloaca and interfering with progesterone (P4) secretion by follicular granulosa cells (GCs), seriously affecting the health of breeding geese. miRNAs are small, non-coding RNAs with a variety of important regulatory roles. To investigate the mechanism of miR-10a-5p mediated LPS inhibition of progesterone synthesis in goose granulosa cells, Yangzhou geese at peak laying period were selected as experimental animals to verify the expression levels of genes and transcription factors related to progesterone synthesis. In this study, bioinformatic predictions identified miR-10a-5p target gene CYP11A1, and genes and transcription factors related to the sex steroid hormone secretion pathway were screened. We detected that LPS inhibited CYP11A1 expression while increasing miR-10a-5p expression in vivo. Progesterone decreased significantly in goose granulosa cells treatment with 1 μg/mL LPS for 24 h, while progesterone-related genes and regulatory factors were also suppressed. We also determined that the downregulation of miR-10a-5p led to CYP11A1 expression. Overexpression of miR-10a-5p suppressed LPS-induced CYP11A1 expression, resulting in decreased progesterone secretion. Our findings indicated that miR-10a-5p was up-regulated by LPS and inhibited progesterone synthesis by down-regulating CYP11A1. This study provides insight into the molecular mechanisms regulating geese reproduction and ovulation.
Health and Economic Benefits of Complying With the World Health Organization Air Quality Guidelines for Particulate Matter in Nine Major Latin American Cities
Authors: Madaniyazi Lina , Alpízar Jefferson , Cifuentes Luis Abdón , Riojas-Rodríguez Horacio , Hurtado Díaz Magali , de Sousa Zanotti Stagliorio Coelho Micheline , Abrutzky Rosana , Osorio Samuel , Carrasco Escobar Gabriel , Valdés Ortega Nicolás , Colistro Valentina , Roye Dominic , Tobías Aurelio
Published: May 2024

Objectives

This study aims to estimate the short-term preventable mortality and associated economic costs of complying with the World Health Organization (WHO) air quality guidelines (AQGs) limit values for PM10 and PM2.5 in nine major Latin American cities.

Methods

We estimated city-specific PM-mortality associations using time-series regression models and calculated the attributable mortality fraction. Next, we used the value of statistical life to calculate the economic benefits of complying with the WHO AQGs limit values.

Results

In most cities, PM concentrations exceeded the WHO AQGs limit values more than 90% of the days. PM10 was found to be associated with an average excess mortality of 1.88% with concentrations above WHO AQGs limit values, while for PM2.5 it was 1.05%. The associated annual economic costs varied widely, between US$ 19.5 million to 3,386.9 million for PM10, and US$ 196.3 million to 2,209.6 million for PM2.5.

Conclusion

Our findings suggest that there is an urgent need for policymakers to develop interventions to achieve sustainable air quality improvements in Latin America. Complying with the WHO AQGs limit values for PM10 and PM2.5 in Latin American cities would substantially benefits for urban populations.
Activity Modeling and Characterization for Airport Bird Situation Awareness Using Avian Radar Datasets
Authors: Liu Jia , Xu Qunyu , Su Min , Chen Weishi
Published: May 2024

Birds in airport airspaces are critical threats to aviation safety. Avian radar systems are effective for long-range bird monitoring and hazard warning, but their functionalities are confined to a short-term temporal scale. Spatial–temporal activity modeling and characterization for birds are not studied comprehensively from historical radar datasets. This paper proposes a radar data analysis framework to characterize bird activities as a long-term functionality complement. Spatial domain modeling initializes data mining by extracting reference spots for data filtering. Bird activities are quantified in the temporal domain. Activity degrees are utilized for periodicity extraction with the daily segment random permutation strategy. Categorical probabilities are calculated to interpret bird activity periodicity characters. Historical radar datasets collected from an avian radar system are adopted for validation. The extracted activity periodicity trends for diurnal birds present prominent consistency with artificial observation records. Migratory bird periodicity trends present a good match with ornithology understandings. A preliminary experiment is presented to indicate the possibility of predicting bird activity levels, especially for migratory birds.
Theoretical and Experimental Verification of the Physical–Mechanical Properties of Organic Bone Meal Granular Fertilizers
Authors: Jotautienė Eglė , Bivainis Vaidas , Karayel Davut , Mieldažys Ramūnas
Published: May 2024

Continuous efforts are being made to improve fertilizer efficiency by improving fertilizer technology, quality, and application rates. Granular organic fertilizers are more difficult to achieve uniform application because their physical–mechanical properties differ significantly from mineral fertilizers. The properties of granular organic fertilizers can best be determined experimentally. However, these studies are often quite complex. Modern engineering modeling software makes it possible to model the properties of granular fertilizers and their dispersion. This study deals with the theoretical and experimental verification of the physical–mechanical properties of organic bone meal granular fertilizer. For the verification of selected properties of bone meal granules, the following studies were carried out on the granules: determination of poured bulk density, static and dynamic angles of repose, static and dynamic friction coefficients of granule surface, etc. The results showed that for modeling fertilizer properties, it is sufficient to carry out a static compression test to determine the modulus of elasticity and a friction test between granules and the contacting surface to determine the static and dynamic friction coefficients. The remaining properties of the granules can be modeled and calibrated with the DEM software Altair EDEM 2023.
Silicon Foliar Fertilisation Ameliorates Olive Leaves Polyphenolic Compounds Levels and Elevates Its Potential towards Different Cancer Cells
Authors: Pasković Igor , Franić Mario , Polić Pasković Marija , Talhaoui Nassima , Marcelić Šime , Lukić Igor , Fredotović Željana , Žurga Paula , Major Nikola , Goreta Ban Smiljana , Vidović Nikolina , Rončević Sanda , Nemet Ivan , Džafić Natalija , Soldo Barbara
Published: May 2024

It is not yet clear how adding silicon foliar fertilisation affects olive leaf (OL) phenolics and their potential to impact different cancer cells. Thus, we conducted a field trial to study the effect of foliar Si biostimulant fertilisation on the OL phenolic content of the ‘Leccino’ (LE) and ‘Istarska Bjelica’ (IB) cultivars. The experiment compared untreated Control (C) and three distinct levels of silicon (Si1, Si2, Si3) with Si concentrations of 0.55 g/L, 1.1 g/L, and 2.2 g/L, respectively. Si3 application resulted in the highest levels of oleuropein, apigenin-7-O-glucoside, luteolin-4-O-glucoside, rutin, and tyrosol compared to the C treatment. The polyphenols showed high cytotoxic activity in three cancer cell lines tested: cervical adenocarcinoma (HeLa), colon cancer (HCT116), and osteosarcoma (U2OS). The strongest inhibition of cell growth was observed in the HCT116 cell line. All cancer cells tested were more sensitive to treatment with polyphenols isolated from plants with added Si than those without added Si. The cytotoxic activity of the extracts on the healthy cell line RPE1 was similar to that on the cancer cell line HCT116 and U2OS.
Production of Polymeric Films from Orange and Ginger Waste for Packaging Application and Investigation of Mechanical and Thermal Characteristics of Biofilms
Authors: Moaveni Raouf , Ghane Mohammad , Soltani Parham , Zamani Akram , Ramamoorthy Sunil Kumar
Published: May 2024

Citrus waste has been used as a source of bioplastics for research in different ways. Because the juice industry produces significant amounts of residue each year, it would be advantageous to use the byproducts in the creation of new materials. Researchers have long explored eco-friendly methods to convert citrus and other organic waste into polymers for producing biodegradable films. The goal of this study is to create biofilms from orange waste (OW) and ginger waste (GW) using an ultrafine grinder and study the films’ properties. Since pectin has the ability to gel, and because cellulosic fibers are strong, citrus waste has been studied for its potential to produce biofilms. After being washed, dried, and milled, orange and ginger waste was shaped into films using a casting process. Tensile testing was used to determine the mechanical properties of biofilms, while dynamic mechanical thermal analysis (DMTA), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) were used to determine their thermal properties. As the number of grinding cycles increased, the suspension’s viscosity increased from 29 mPa.s to 57 mPa.s for OW and from 217 mPa.s to 376 mPa.s for GW, while the particle size in the suspension significantly decreased. For OW and GW films, the highest tensile strength was 17 MPa and 15 MPa, respectively. The maximum strain obtained among all films was 4.8%. All the tested films were stable up to 150 °C, and maximum degradation occured after 300 °C.
Uncertainty in Automated Ontology Matching: Lessons from an Empirical Evaluation
Authors: Osman Inès , Pileggi Salvatore Flavio , Yahia Sadok Ben
Published: May 2024

Data integration is considered a classic research field and a pressing need within the information science community. Ontologies play a critical role in such processes by providing well-consolidated support to link and semantically integrate datasets via interoperability. This paper approaches data integration from an application perspective by looking at ontology matching techniques. As the manual matching of different sources of information becomes unrealistic once the system scales up, the automation of the matching process becomes a compelling need. Therefore, we have conducted experiments on actual non-semantically enriched relational data with the support of existing tools (pre-LLM technology) for automatic ontology matching from the scientific community. Even considering a relatively simple case study—i.e., the spatio–temporal alignment of macro indicators—outcomes clearly show significant uncertainty resulting from errors and inaccuracies along the automated matching process. More concretely, this paper aims to test on real-world data a bottom-up knowledge-building approach, discuss the lessons learned from the experimental results of the case study, and draw conclusions about uncertainty and uncertainty management in an automated ontology matching process. While the most common evaluation metrics clearly demonstrate the unreliability of fully automated matching solutions, properly designed semi-supervised approaches seem to be mature for more generalized application.
Practical Test on the Operation of the Three-Phase Induction Motor under Single-Phasing Fault
Authors: Abdo Ali , Siam Jamal , Abdou Ahmed , Shehadeh Hakam , Mustafa Rashad
Published: May 2024

Single-phasing is a common problem in the three-phase electrical grid. Despite the fact that the fault occurs in one phasing, the three-phase load is affected, and therefore the load is typically turned off. The three-phase induction motor is the most commonly used in the industry; therefore, this research investigates the behavior of the three-phase induction motor under a single-phasing fault. The main aim of this paper is to answer the question, should the three-phase induction motor be turned off under a single-phasing fault? The problem is investigated theoretically and compared with practical tests to explore the parameters of the induction motor (current, stator temperature, and vibration) that are affected under healthy and single-phasing fault conditions. A practical test machine is built to test the motor behavior under single-phasing faults, where the practical experiment results are compared to those of the simulations. Despite the common recommendation under single-phasing fault is to turn off the induction motors, the preliminary results of this study show that turning off an induction motor under single-phasing can be avoided under certain operating conditions with a simple protection scheme, which is useful in some practical situations.
Selenium Content of Goose Breast Meat Depending on the Type of Heat Processing
Authors: Goluch Zuzanna , Bąkowska Małgorzata , Haraf Gabriela , Pilarczyk Bogumiła
Published: May 2024

Among the foods frequently consumed by consumers is meat. Among other things, it contains selenium, and the content depends on the amount of consumption of this element by animals, which requires monitoring as a metalloid. The purpose of this study was to: examine the impact of various types of heat processing used by consumers (water bath cooking WBC, oven convection roasting OCR, grilling G, pan frying PF) on the selenium content and its retention in goose breast meat (with and without skin) and estimate the coverage of this element’s daily requirement in adults after consuming 100 g of goose breast meat with skin or without skin. The material used in the study comprised 36 breast muscles cut from carcasses of 17-week-old White Koluda geese. The moisture, ash, and selenium were determined in both raw and thermally processed muscles. It has been concluded that various methods of heat processing significantly impact the cooking loss, moisture, ash and selenium content of meat, but not the selenium retention. The heat processing increased the selenium content of the muscle regardless of the presence of skin, which affects the possibility of covering adults’ Nutrient Reference Values-Requirements (NRV-R) for this element in the range of 33.3–44.8%. Goose breast meat can be a valuable component of a diversified diet. It is also a safe source of selenium. It is unlikely that adult consumers, even those who eat goose regularly, will exceed this element’s upper tolerable intake level. For selenium retention and NRV-R coverage, consumers would benefit most from goose breast meat with or without skin undergoing OCR or G treatment.
Effectiveness of Erythrocyte Morphology Observation as an Indicator for the Selection and Qualification of Blood in a Mechanically Induced Hemolysis Test
Authors: Kim Jeonghwa , Kim Taeho , Kim Sekyung , Eom Joonho , Kim Taewon
Published: May 2024

Background: This study was conducted to confirm the reliability of an in vitro mechanically induced hemolysis test (ISO 10993-4:2017), which is essential for ensuring the safety of blood pumps. Methods: For appropriate anticoagulant selection, porcine blood was prepared in anticoagulant citrate dextrose solution A (ACD-A), heparin, and citrate phosphate dextrose adenine (CPDA-1), respectively, according to the ASTM F1830 standard. Anticoagulant-treated porcine and bovine blood were circulated in a mock circulatory loop (MCL) for 6 h to observe the rate of plasma-free hemoglobin (pfHb) and RBCs with morphological integrity. Results: A morphological loss of red blood cells (RBCs) was observed over time. While there were differences in morphological loss depending on the anticoagulant, no consistent trend could be identified. The pfHb concentration was significantly higher in bovine than in porcine blood. Conversely, the number of RBCs with morphological integrity decreased over time in both, but the ratio of RBCs with morphological integrity was similar across all timepoints. Conclusions: The percentage of RBCs with morphological integrity can be used as a reliable indicator for the interpretation of mechanically induced hemolysis results in different blood types. Furthermore, the reliability of the in vitro mechanically induced hemolysis test (ISO 10993-4:2017) was assessed.
Magnetic Negative Stiffness Devices for Vibration Isolation Systems: A State-of-the-Art Review from Theoretical Models to Engineering Applications
Authors: Zhu Qingbo , Chai Kai
Published: May 2024

This paper presents a comprehensive state-of-the-art review of magnetic negative stiffness (MNS) devices in the realm of vibration isolation systems, spanning from foundational theoretical models to practical engineering applications. The emergence of MNS technology represents a significant advancement in the field of vibration isolation, introducing a method capable of achieving near-zero stiffness to effectively attenuate low-frequency vibration. Through a systematic exploration of the evolution of vibration isolation methodologies—encompassing passive, active, and hybrid techniques—this article elucidates the underlying principles of quasi-zero stiffness (QZS) and investigates various configurations of MNS isolators, such as the linear spring, bending beam, level spring-link, and cam-roller designs. Our comprehensive analysis extends to the optimization and application of these isolators across diverse engineering domains, highlighting their pivotal role in enhancing the isolation efficiency against low-frequency vibrations. By integrating experimental validations with theoretical insights, this study underscores the transformative potential of MNS devices in redefining vibration isolation capabilities, particularly in expanding the isolation frequency band while preserving the load-bearing capacities. As the authors of this review, not only are the current advancements within MNS device research cataloged but also future trajectories are projected, advocating for continued innovation and tailored designs to fully exploit the advantages of MNS technology in specialized vibration isolation scenarios.
Acoustic Pressure Amplification through In-Duct Sonic Black Holes
Authors: Maury Cédric , Bravo Teresa , Amielh Muriel , Mazzoni Daniel
Published: May 2024

Acoustic detection of machinery defaults from in-duct measurements is of practical importance in many areas, such as the health assessment of turbines in ventilation systems or engine testing in the surface and air transport sectors. This approach is, however, impeded by the low signal-to-noise ratio (SNR) observed in such environments. In this study, it is proposed to exploit the slow sound effect of Sonic Black Hole (SBH) ducted silencers to enhance the sensing of incident pulse acoustic signals with low SNR. It is found from transfer matrix and finite element modelling that fully opened SBH silencers with perforated skin interfaces are able to substantially enhance an incident pulse amplitude while channeling an air flow. We demonstrate that the graded depths of the SBH cavities provide rainbow spectral decomposition and amplification of the incident pulse frequency components, provided that impedance matching, slow sound, and critically coupled conditions are met. In-duct experiments showed the ability of a 3D printed SBH silencer to simultaneously enhance acoustic sensing and fully trap the pulse spectral components in the SBH cavities in the presence of a low-speed flow. This study opens up new avenues for the development of dual-purpose silencers designed for acoustic monitoring and noise control in duct systems without obstructing the air flow.
Immersive Virtual Reality High-Intensity Aerobic Training to Slow Parkinson’s Disease: The ReViPark Program
Authors: Rodríguez-Fuentes Gustavo , Campo-Prieto Pablo , Cancela-Carral José Ma
Published: May 2024

Intense exercise can be neuromodulatory and neuroprotective against Parkinson’s disease (PD). Indoor cycling is a good and safe option for this population, but some barriers (monotonous and repetitive environment, lack of monitoring, and an inability to compete with others) could limit its use. Immersive virtual reality (IVR) could be a possible solution to some of these drawbacks, increasing patient motivation and thus adherence to forced exercise programs using cycloergometers. A double-blind, randomized, controlled clinical trial was conducted to explore the feasibility and effects of the ReViPark program (high-intensity pedaling + IVR for 3 months with two sessions per week) on PD progression. In all, 52 people with PD were allocated to the ReViPark group (n = 30; 70.87 ± 6.67 years) and smart cycloergometer group (n = 22; 70.59 ± 6.67 years). This program was feasible, with no adverse effects (no significant Simulator Sickness Questionnaire symptoms and a low negative experience rating for the Game Experience Questionnaire (0.04/4)), no dropouts, high adherence, and good usability (System Usability Scale score of 82.90%). The ReViPark group showed significant improvements in functionality, quality of life, and disease progression as measured by their balance, gait and risk of falling (Timed Up and Go p = 0.028; Tinetti test p = 0.046), PDQ-39 scores (p = 0.035), and MDS-UPDRS scores (p = 0.001). This program is feasible and could lead to improvements in the functional parameters, quality of life, and symptomatology of the participants.
Automated Multi-Type Pavement Distress Segmentation and Quantification Using Transformer Networks for Pavement Condition Index Prediction
Authors: Zhang Zaiyan , Song Weidong , Zhuang Yangyang , Zhang Bing , Wu Jiachen
Published: May 2024

Pavement distress detection is a crucial task when assessing pavement performance conditions. Here, a novel deep-learning method based on a transformer network, referred to as ISTD-DisNet, is proposed for multi-type pavement distress semantic segmentation. In this methodology, a mix transformer (MiT) based on a hierarchical transformer structure is chosen as the backbone to obtain multi-scale feature information on pavement distress, and a mixed attention module (MAM) is introduced at the decoding stage to capture the pavement distress features across different channels and spatial locations. A learnable transposed convolution upsampling module (TCUM) enhances the model’s ability to restore multi-scale distress details. Subsequently, a novel parameter—the distress pixel density ratio (PDR)—is introduced based on the segmentation results. Analyzing the intrinsic correlation between the PDR and the pavement condition index (PCI), a new pavement damage index prediction model is proposed. Finally, the experimental results reveal that the F1 and mIOU of the proposed method are 95.51% and 91.67%, respectively, and the segmentation performance is better than that of the other seven mainstream segmentation models. Further PCI prediction model validation experimental results also indicate that utilizing the PDR enables the quantitative evaluation of the pavement damage conditions for each assessment unit, holding promising engineering application potential.
Loop-Terminated Mach–Zehnder Interferometer Integrated with Functional Polymer for CO2 Gas Sensing
Authors: Butt Muhammad A.
Published: May 2024

In this work, a numerical study on the loop-terminated Mach–Zehnder interferometer (LT-MZI) structure for CO2 gas sensing applications is carried out via the finite element method. The sensing arm is covered with a polyhexamethylene biguanide (PHMB) polymer which is highly receptive to CO2 gas. The refractive index of the host material decreases due to the absorption of the CO2 gas resulting in a shift in the interference pattern of the LT-MZI structure. As a result, a redshift in the wavelength is observed in the transmission spectrum of the device. The sensitivity of the device is estimated at 7.63 pm/ppm, 34.46 pm/ppm, and 74.78 pm/ppm for the sensing arm lengths of 5 µm, 10 µm, and 15 µm, respectively. The sensitivity can be further enhanced, however, at the cost of the bigger footprint of the device. Utilizing the innovative sensor design, a comprehensive range of CO2 gas concentrations spanning from 0 to 524 ppm is effectively detected. This compact and highly sensitive device serves as a vital tool for monitoring indoor CO2 levels, fostering a healthier breathing environment for all occupants.
Microplastics’ Detection in Honey: Development of Protocols in a Simulation
Authors: Katsara Klytaimnistra , Viskadourakis Zacharias , Alissandrakis Eleftherios , Kountourakis Nikos , Kenanakis George , Papadakis Vassilis M.
Published: May 2024

Honey, renowned for its nutritional and therapeutic properties, has recently come under scrutiny due to its contamination by microplastics, in multiple ways. Bees’ exposure to plastic pollution impacts the whole hive’s ecosystem, and plastic tends to accumulate in hive products. Plastic packaging as polyethylene terephthalate (PET) is used to store honey in small flexible packages, which also increases the risk of microplastic migration. This study aims to establish three practical detection methods for PET microplastics and nanoplastics in honey, using readily available laboratory equipment without the need for chemical digestion or costly pretreatment protocols, in a laboratory-based simulation. The first method utilizes Raman micro-spectroscopy, offering high-resolution identification of PET microplastics on cellulose acetate filters with Raman mapping, eliminating the need for organic solvents or dyes. The second method employs optical microscopic observation under fluorescence with the aid of 4-dimethylamino-4′-nitrostilbene dye and ultraviolet radiation to enhance microplastic visibility, making it suitable for laboratories with standard optical microscopes. To isolate MPs from the solid honey particles, a density separator has been introduced using pentane. Lastly, the third method employs the use of electrospray ionization mass spectrometry for the detection of nanoplastics (<200 nm) in honey samples, through the examination of the different extraction phases of density separation. All the aforementioned methods contribute to efficient microplastic detection in honey, ensuring its quality and safe consumption.
Graph-Driven Exploration of Issue Handling Schemes in Software Projects
Authors: Dobrzyński Bartosz , Sosnowski Janusz
Published: May 2024

The Issue Tracking System (ITS) repositories are rich sources of software development documentation that are useful in assessing the status and quality of software projects. An original model is proposed for tracing issue handling activities and their impact on project progress. As opposed to classical data mining of software repositories, we consider fine-grained features of issues which provide a better insight into project evolution. A thorough analysis of repository contents allows us to define useful metrics for characterizing issue handling schemes. These metrics are derived from the introduced graph model and developed original data mining algorithms targeting timing, issue flow progress and project actor activity aspects. This study is associated with issue processing states and their sequences (handling paths), leading to problem resolution. The introduced taxonomy of issue processing schemes facilitates the creation of a pertinent knowledge database and the identification of both bad (anomalies) and good practices. The proposed approach is illustrated with experimental results related to a representative set of ITS project repositories. These results enhance experts’ knowledge of the project and can be used for correct decision-making actions. They reveal weak points in project development and possible directions for improvement.