bluuebunny/crossref_metadata_2025 huggingface dataset:
In vivo multi-parametric manganese-enhanced MRI for detecting amyloid plaques in rodent models of Alzheimer’s disease
Authors: Kim Eugene , Di Censo Davide , Baraldo Mattia , Simmons Camilla , Rosa Ilaria , Randall Karen , Ballard Clive , Dickie Ben R. , Williams Steven C. R. , Killick Richard , Cash Diana
Published: June 2021

Amyloid plaques are a hallmark of Alzheimer’s disease (AD) that develop in its earliest stages. Thus, non-invasive detection of these plaques would be invaluable for diagnosis and the development and monitoring of treatments, but this remains a challenge due to their small size. Here, we investigated the utility of manganese-enhanced MRI (MEMRI) for visualizing plaques in transgenic rodent models of AD across two species: 5xFAD mice and TgF344-AD rats. Animals were given subcutaneous injections of MnCl2 and imaged in vivo using a 9.4 T Bruker scanner. MnCl2 improved signal-to-noise ratio but was not necessary to detect plaques in high-resolution images. Plaques were visible in all transgenic animals and no wild-types, and quantitative susceptibility mapping showed that they were more paramagnetic than the surrounding tissue. This, combined with beta-amyloid and iron staining, indicate that plaque MR visibility in both animal models was driven by plaque size and iron load. Longitudinal relaxation rate mapping revealed increased manganese uptake in brain regions of high plaque burden in transgenic animals compared to their wild-type littermates. This was limited to the rhinencephalon in the TgF344-AD rats, while it was most significantly increased in the cortex of the 5xFAD mice. Alizarin Red staining suggests that manganese bound to plaques in 5xFAD mice but not in TgF344-AD rats. Multi-parametric MEMRI is a simple, viable method for detecting amyloid plaques in rodent models of AD. Manganese-induced signal enhancement can enable higher-resolution imaging, which is key to visualizing these small amyloid deposits. We also present the first in vivo evidence of manganese as a potential targeted contrast agent for imaging plaques in the 5xFAD model of AD.
Exploring antimicrobial resistance to beta-lactams, aminoglycosides and fluoroquinolones in E. coli and K. pneumoniae using proteogenomics
Authors: Foudraine Dimard E. , Strepis Nikolaos , Stingl Christoph , ten Kate Marian T. , Verbon Annelies , Klaassen Corné H. W. , Goessens Wil H. F. , Luider Theo M. , Dekker Lennard J. M.
Published: June 2021

Antimicrobial resistance is mostly studied by means of phenotypic growth inhibition determinations, in combination with PCR confirmations or further characterization by means of whole genome sequencing (WGS). However, the actual proteins that cause resistance such as enzymes and a lack of porins cannot be detected by these methods. Improvements in liquid chromatography (LC) and mass spectrometry (MS) enabled easier and more comprehensive proteome analysis. In the current study, susceptibility testing, WGS and MS are combined into a multi-omics approach to analyze resistance against frequently used antibiotics within the beta-lactam, aminoglycoside and fluoroquinolone group in E. coli and K. pneumoniae. Our aim was to study which currently known mechanisms of resistance can be detected at the protein level using liquid chromatography–mass spectrometry (LC–MS/MS) and to assess whether these could explain beta-lactam, aminoglycoside, and fluoroquinolone resistance in the studied isolates. Furthermore, we aimed to identify significant protein to resistance correlations which have not yet been described before and to correlate the abundance of different porins in relation to resistance to different classes of antibiotics. Whole genome sequencing, high-resolution LC–MS/MS and antimicrobial susceptibility testing by broth microdilution were performed for 187 clinical E. coli and K. pneumoniae isolates. Resistance genes and proteins were identified using the Comprehensive Antibiotic Resistance Database (CARD). All proteins were annotated using the NCBI RefSeq database and Prokka. Proteins of small spectrum beta-lactamases, extended spectrum beta-lactamases, AmpC beta-lactamases, carbapenemases, and proteins of 16S ribosomal RNA methyltransferases and aminoglycoside acetyltransferases can be detected in E. coli and K. pneumoniae by LC–MS/MS. The detected mechanisms matched with the phenotype in the majority of isolates. Differences in the abundance and the primary structure of other proteins such as porins also correlated with resistance. LC–MS/MS is a different and complementary method which can be used to characterize antimicrobial resistance in detail as not only the primary resistance causing mechanisms are detected, but also secondary enhancing resistance mechanisms.
Author Correction: Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis
Authors: Yamashita Toru , Kushida Yoshihiro , Wakao Shohei , Tadokoro Koh , Nomura Emi , Omote Yoshio , Takemoto Mami , Hishikawa Nozomi , Ohta Yasuyuki , Dezawa Mari , Abe Koji
Published: June 2021

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Reproductive risk factors of pterygium in postmenopausal women: a nationwide study in the Republic of Korea
Authors: Shin Eunhae , Lim Dong Hui , Chung Tae-Young , Han Gyule , Yoo Jung Eun , Jeon Keun Hye , Han Kyungdo , Shin Dong Wook
Published: June 2021

This study is to elucidate the associations between female reproductive factors and pterygium. A total of 1,339,969 postmenopausal women in a retrospective cohort of Korean National Health Insurance Service data on ages 40 and above in 2009 was included. Cox proportional hazards regression was conducted to assess the hazard ratio (HR) for pterygium according to reproductive factors. Late menarche, early menopause, short reproductive period, increasing parity (≥ 2 children), breastfeeding (≥ 6 months), and no use of hormone replacement therapy (HRT) or oral contraceptive (OC) were significantly associated with risk of pterygium. In multivariate analysis, the HR for pterygium was 1.764 (95% confidence interval [CI], 1.529–2.035) for menarche age ≥ 17 years (reference: menarche age < 12 years). The HR of menopause age ≥ 55 years was 0.782 (95% CI, 0.724–0.845) (reference: menopause age < 40 years). The HR of parity ≥ 2 was 1.261 (95% CI, 1.148–1.385) (reference: nulliparity). The HR of breastfeeding ≥ 1 year was 1.663 (95% CI, 1.564–1.768) (reference: no breastfeeding). The HRs of HRT and OC use for any length of time were lower than those for the non-user groups (reference). Reproductive factors that increase estrogen exposure have protective effects against pterygium in females.
Development and external validation of a nomogram for predicting preterm birth at < 32 weeks in twin pregnancy
Authors: Zhang Jun , Zhan Wenqiang , Lin Yanling , Yang Danlin , Li Li , Xue Xiaoying , Lin Zhi , Pan Mian
Published: June 2021

The purpose of this study was to develop a dynamic model to predict the risk of spontaneous preterm birth at < 32 weeks in twin pregnancy. A retrospective clinical study of consecutively asymptomatic women with twin pregnancies from January 2017 to December 2019 in two tertiary medical centres was performed. Data from one centre were used to construct the model, and data from the other were used to evaluate the model. Data on maternal demographic characteristics, transvaginal cervical length and funnelling during 20–24 weeks were extracted. The prediction model was constructed with independent variables determined by multivariate logistic regression analyses. After applying specified exclusion criteria, an algorithm with maternal and biophysical factors was developed based on 88 twin pregnancies with a preterm birth < 32 weeks and 639 twin pregnancies with a delivery ≥ 32 weeks. It was then evaluated among 34 pregnancies with a preterm birth < 32 weeks and 252 pregnancies with a delivery ≥ 32 weeks in a second tertiary centre without specific training. The model reached a sensitivity of 80.00%, specificity of 88.17%, positive predictive value of 50.33% and negative predictive value of 96.71%; ROC characteristics proved that the model was superior to any single parameter with an AUC of 0.848 (all P < 0.005). We developed and validated a dynamic nomogram model to predict the individual probability of early preterm birth to better represent the complex aetiology of twin pregnancies and hopefully improve the prediction and indication of interventions.
Higher cMET dependence of sacral compared to clival chordoma cells: contributing to a better understanding of cMET in chordoma
Authors: Lohberger Birgit , Scheipl Susanne , Heitzer Ellen , Quehenberger Franz , de Jong Danielle , Szuhai Karoly , Liegl-Atzwanger Bernadette , Rinner Beate
Published: June 2021

Chordomas are rare slow growing, malignant bone tumors of the axial skeleton with no approved medical treatment. As the majority of chordomas express cMET and its ligand, HGF, and crosstalks between EGFR and MET-signaling exist, we aimed to explore cMET activity in chordoma cell lines and clinical samples. We investigated nine chordoma patients and four chordoma cell lines for cMET expression. Two clival and two sacral chordoma cell lines were tested for chromosomal abnormalities of the MET gene locus; we studied the influence of HGF on the autocrine secretion and migration behavior, as well as protein expression and phosphorylation. Two MET/ALK inhibitors were investigated for their effects on cell viability, cell cycle, cyclin alterations, apoptosis, and downstream signaling pathways. Moderate and strong expression of membrane and cytoplasmic cMET in chordoma patients and cell lines used, as well as concentration-dependent increase in phospho cMET expression after HGF stimulation in all four chordoma cell lines was shown. U-CH2, MUG-Chor1, and UM-Chor1 are polysomic for MET. Chordoma cell lines secreted EGF, VEGF, IL-6, and MMP9 upon HGF-stimulation. Sacral cell lines showed a distinct HGF-induced migration. Both inhibitors dose-dependently inhibited cell growth, induce apoptosis and cell-cycle arrest, and suppress downstream pathways. Heterogeneous responses obtained in our in vitro setting indicate that cMET inhibitors alone or in combination with other drugs might particularly benefit patients with sacral chordomas.
Design of a miniaturized ultrawideband and low scattering antipodal vivaldi antenna array
Authors: Liu Jia , Xu Chengxiang , Yu Hang , Su Jianxun
Published: June 2021

This paper presents a miniaturized ultra-wideband (UWB) antipodal Vivaldi antenna (AVA) array with low-scattering characteristics integrated a hybrid diffusive-absorptive metasurface. Periodic elliptical slots at the outer edges and a dielectric lens are utilized for antenna element to improve performances including miniaturized size, wide bandwidth, and high gain. The optimized element is fabricated and measured, the results demonstrate that the − 10 dB impedance bandwidth is 4.5–50 GHz with a ratio bandwidth (fH/fL) of 11.1:1, and the maximum gain at 35 GHz is 12.7 dBi, which are in good agreement with simulation. By loading an optimized Minkowski-shaped metasurface as the ground reflector, which combines the multielement phase cancellation (MEPC) and EM absorption technology, the 4 × 4 array realizes a low radar cross section (RCS) without the radiation performance degradation. Simulated and measured results show that the proposed low-scattering array has a 10-dB RCS reduction band ranging from 5 to 50 GHz at normal incidence for both polarizations. Furthermore, the array structure shows extremely low-observable capability, which is larger than 15 dB of the RCS reduction from 7.1 to 50 GHz with a ratio bandwidth of 7.0:1. The results verify the feasibility of improving the performance of antenna and the UWB low-scattering functionality.
Jejunal mucosa proteomics unravel metabolic adaptive processes to mild chronic heat stress in dairy cows
Authors: Koch Franziska , Albrecht Dirk , Görs Solvig , Kuhla Björn
Published: June 2021

Climate change affects the duration and intensity of heat waves during summer months and jeopardizes animal health and welfare. High ambient temperatures cause heat stress in dairy cows resulting in a reduction of milk yield, feed intake, and alterations in gut barrier function. The objectives of this study were to investigate the mucosal amino acid, glucose and lactate metabolism, as well as the proteomic response of the small intestine in heat stressed (HS) Holstein dairy cows. Cows of the HS group (n = 5) were exposed for 4 days to 28 °C (THI = 76) in a climate chamber. Percentage decrease in daily ad libitum intake of HS cows was calculated to provide isocaloric energy intake to pair-fed control cows kept at 15 °C (THI = 60) for 4 days. The metabolite, mRNA and proteomic analyses revealed that HS induced incorrect protein folding, cellular destabilization, increased proteolytic degradation and protein kinase inhibitor activity, reduced glycolysis, and activation of NF-κB signaling, uronate cycling, pentose phosphate pathway, fatty acid and amino acid catabolism, mitochondrial respiration, ATPase activity and the antioxidative defence system. Our results highlight adaptive metabolic and immune mechanisms attempting to maintain the biological function in the small intestine of heat-stressed dairy cows.
Yet Another Automated Gleason Grading System (YAAGGS) by weakly supervised deep learning
Authors: Mun Yechan , Paik Inyoung , Shin Su-Jin , Kwak Tae-Yeong , Chang Hyeyoon
Published: June 2021

The Gleason score contributes significantly in predicting prostate cancer outcomes and selecting the appropriate treatment option, which is affected by well-known inter-observer variations. We present a novel deep learning-based automated Gleason grading system that does not require extensive region-level manual annotations by experts and/or complex algorithms for the automatic generation of region-level annotations. A total of 6664 and 936 prostate needle biopsy single-core slides (689 and 99 cases) from two institutions were used for system discovery and validation, respectively. Pathological diagnoses were converted into grade groups and used as the reference standard. The grade group prediction accuracy of the system was 77.5% (95% confidence interval (CI): 72.3–82.7%), the Cohen’s kappa score (κ) was 0.650 (95% CI: 0.570–0.730), and the quadratic-weighted kappa score (κquad) was 0.897 (95% CI: 0.815–0.979). When trained on 621 cases from one institution and validated on 167 cases from the other institution, the system’s accuracy reached 67.4% (95% CI: 63.2–71.6%), κ 0.553 (95% CI: 0.495–0.610), and the κquad 0.880 (95% CI: 0.822–0.938). In order to evaluate the impact of the proposed method, performance comparison with several baseline methods was also performed. While limited by case volume and a few more factors, the results of this study can contribute to the potential development of an artificial intelligence system to diagnose other cancers without extensive region-level annotations.
Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons
Authors: Sanchez Carlos G. , Acker Christopher M. , Gray Audrey , Varadarajan Malini , Song Cheng , Cochran Nadire R. , Paula Steven , Lindeman Alicia , An Shaojian , McAllister Gregory , Alford John , Reece-Hoyes John , Russ Carsten , Craig Lucas , Capre Ketthsy , Doherty Christian , Hoffman Gregory R. , Luchansky Sarah J. , Polydoro Manuela , Dolmetsch Ricardo , Elwood Fiona
Published: June 2021

Aggregates of hyperphosphorylated tau protein are a pathological hallmark of more than 20 distinct neurodegenerative diseases, including Alzheimer’s disease, progressive supranuclear palsy, and frontotemporal dementia. While the exact mechanism of tau aggregation is unknown, the accumulation of aggregates correlates with disease progression. Here we report a genome-wide CRISPR screen to identify modulators of endogenous tau protein for the first time. Primary screens performed in SH-SY5Y cells, identified positive and negative regulators of tau protein levels. Hit validation of the top 43 candidate genes was performed using Ngn2-induced human cortical excitatory neurons. Using this approach, genes and pathways involved in modulation of endogenous tau levels were identified, including chromatin modifying enzymes, neddylation and ubiquitin pathway members, and components of the mTOR pathway. TSC1, a critical component of the mTOR pathway, was further validated in vivo, demonstrating the relevance of this screening strategy. These findings may have implications for treating neurodegenerative diseases in the future.
Cubic spline-based depth-dependent localization of mitochondria-endoplasmic reticulum contacts by three-dimensional light-sheet super-resolution microscopy
Authors: Sun Yucheng , Lee Seungah , Kang Seong Ho
Published: June 2021

The contact distance between mitochondria (Mito) and endoplasmic reticulum (ER) has received considerable attention owing to their crucial function in maintaining lipid and calcium homeostasis.
Three-dimensionally printable shear-thinning triblock copolypeptide hydrogels with antimicrobial potency
Authors: Murphy Robert , Kordbacheh Shadi , Skoulas Dimitrios , Ng Simon , Suthiwanich Kasinan , Kasko Andrea M. , Cryan Sally-Ann , Fitzgerald-Hughes Deirdre , Khademhosseini Ali , Sheikhi Amir , Heise Andreas
Published: June 2021

Block sequence controlled triblock copolypeptides comprising a lysine or glutamic acid central block flanked by cysteine and tyrosine blocks combine exceptional hydrogel printability with antimicrobial properties.
Photodegradable avidin-biotinylated polymer conjugate hydrogels for cell manipulation
Authors: Yamaguchi Satoshi , Ohashi Noriyuki , Minamihata Kosuke , Nagamune Teruyuki
Published: June 2021

Photodegradable avidin-biotinylated polymer conjugate hydrogels achieved cell elongation through peptide decoration and selective cell release by light.
Highly selective two-photon fluorescent off–on probes for imaging tyrosinase activity in living cells and tissues
Authors: Cui Yixin , Park Sang Jun , Wu Xiaofeng , Wang Rui , Qi Sujie , Kim Hwan Myung , Yoon Juyoung
Published: June 2021

A two-photon fluorescent probe with high selectivity and sensitivity has been developed and applied to image tyrosinase activity in cells and tissues.
Luminescent cluster-organic frameworks constructed from predesigned supertetrahedral {Ln4Zn6} secondary building units
Authors: Ge Rui , Liu Jin-Hua , Li Xin-Hao , Li Ling-Yun , Sun Yan-Qiong , Li Zhikai , Li Xin-Xiong , Zheng Shou-Tian
Published: June 2021

A new type of 3d–4f supertetrahedral cluster has been introduced for the first time as a secondary building unit to construct luminescent cluster-organic frameworks with tunable emission, demonstrating a promising strategy for new optical materials.
Infrared spectroscopic measurements of the structure of organic thin films; furfural on Pd(111) and Au(111) surfaces
Authors: Bavisotto Robert , Hopper Nicholas , Boscoboinik Alejandro , Owen Quintus , Tysoe Wilfred T.
Published: June 2021

This work demonstrates the use of reflection–adsorption infrared spectroscopy for continually monitoring the structure of organic thin films as a function of thickness and temperature to complement diffraction methods.
Unprecedented copper(ii) coordination induced nucleophilic cleavage of a quinoxaline heterocycle: structural and computational studies
Authors: Bandopadhyay Nilaj , Joshi Mayank , Armaković Stevan , Armaković Sanja J. , Das Hari Sankar , Roy Choudhury Angshuman , Biswas Bhaskar
Published: June 2021

This research work deals with the unprecedented copper(ii) induced nucleophilic cleavage of a quinoxaline heterocycle with spectroscopic, structural and computational studies.
Hydrated cation–π interactions of π-electrons with hydrated Li+, Na+, and K+ cations
Authors: Mu Liuhua , Yang Yizhou , Liu Jian , Du Wei , Chen Jige , Shi Guosheng , Fang Haiping
Published: June 2021

We give two molecular pictures of hydrated cation–π interactions: graphene sheets interact directly with K+ and Na+ cations, denoted water–cation–π, while graphene sheets interact indirectly with Li+ cation, denoted cation–water–π.
Recent advances and prospects in the iron-catalyzed trifluoromethylation reactions
Authors: Vaishak Thottuvazhiyil Balakrishnan , Soumya Puthukudichola Krishna , Saranya Padinjare Veetil , Anilkumar Gopinathan
Published: June 2021

The development of effective methods to create a C–CF3 bond has attracted great attention in organofluorine chemistry and also in homogeneous catalysis.
Oxidative coupling of methane over sodium zirconate catalyst
Authors: Siritanaratkul Bhavin , Lundin Sean-Thomas B. , Takanabe Kazuhiro
Published: June 2021

Previously only known for CO2absorption and CO oxidation, Na2ZrO3is shown to be a selective catalyst for the oxidative coupling of methane (OCM) by detailed kinetic measurements and kinetic analysis.
Asymmetric azidohydroxylation of styrene derivatives mediated by a biomimetic styrene monooxygenase enzymatic cascade
Authors: Martínez-Montero Lía , Tischler Dirk , Süss Philipp , Schallmey Anett , Franssen Maurice C. R. , Hollmann Frank , Paul Caroline E.
Published: June 2021

A one-pot enzymatic cascade for the asymmetric azidohydroxylation of styrenes leads to chiral 1,2-azido alcohols with up to two stereocenters.
Designing water-quenching resistant highly luminescent europium complexes by regulating the orthogonal arrangement of bis-β-diketone ligands
Authors: Li Mei , Zhou Yanyan , Yao Yuan , Gao Ting , Yan Pengfei , Li Hongfeng
Published: June 2021

The mutually orthogonal arrangement of two bis-β-diketones around the metal center effectively decreases the quenching of Eu3+ ion luminescence caused by water molecules.
Unique interplay between Zn2+ and nZnO determined the dynamic cellular stress in zebrafish cells
Authors: Sun Anqi , Tang Ben Zhong , Tsim Karl Wah-Keung , Wang Wen-Xiong
Published: June 2021

Nano-ZnO with low extracellular dissolution stimulates high lysosomal accumulation and ROS production and exhibits greater cytotoxicity than dissolved Zn2+.
Inhibition of NLRP3 inflammasome activation and pyroptosis with the ethyl acetate fraction ofBungeanumameliorated cognitive dysfunction in aged mice
Authors: Zhao Meihuan , Dai Yuan , Li Ping , Wang Jie , Ma Tengyun , Xu Shijun
Published: June 2021

A schematic illustration of the research. The ethyl acetate active fraction of Bungeanum ameliorated cognitive deficits in aged mice, and its effects may be related to ameliorating oxidative stress and suppressing the NLRP3 inflammasome pathway and GSDMD-mediated pyroptosis.
Multi-elemental analysis of solder using ETV-ICPOES for applications in forensic science
Authors: MacConnachie Margaret , Moghadam Kate , Beauchemin Diane
Published: June 2021

ETV-ICPOES allows the accurate direct analysis of solder in 85 s and matching of melted solder to non-melted one.
An ultrasensitive fluorescent paper sensor for fast screening of berberine
Authors: Guo Lingling , Wang Zhongxing , Xu Xinxin , Xu Liguang , Wang Zhengyou , Kuang Hua , Xu Chuanlai
Published: June 2021

Berberine (BBR) is a highly effective animal feed additive, but it also has adverse side effects on animals and causes potential food safety issues. Based on BBR antibody preparation, fluorescent immunochromatography assay was established for quantitative detection of BBR in feed samples.
Brønsted acid catalysed chemo- and ortho-selective aminomethylation of phenol
Authors: Tang Zhiqiong , Li Dongdong , Yue Yidi , Peng Dan , Liu Lu
Published: June 2021

A Brønsted acid catalysed highly ortho-selective functionalization of free phenols with readily available N,O-acetals under mild conditions has been developed.
Discs, dumbbells and superdiscs: molecular and supermolecular architecture dependent magnetic behavior of mesogenic Blatter radical derivatives
Authors: Kapuściński Szymon , Szczytko Jacek , Pociecha Damian , Jasiński Marcin , Kaszyński Piotr
Published: June 2021

A series of isomeric supermolecular bi-and tri-radicals, in which “half disc” mesogens are connected 1,4- and 1,3,5-through benzene, respectively, are investigated for liquid crystalline and magnetic properties.
Application of the synergistic flame retardant europium hydrotalcite/graphene oxide hybrid material and zinc borate to thermoplastic polyurethane
Authors: Qian Yi , Zheng Jinying , Li Long , Qiao Peng , Li Ying , Duan Yinghui , Chang Guozhang
Published: June 2021

Eu3+ was added to a hydrotalcite laminate to prepare Eu-LDH and was then electrically assembled with GO to prepare an Eu-LDH/GO hybrid material. The flame retardant and smoke suppression properties of the hybrid material mixed with ZB in TPU can be greatly improved.
Disulfide–yne reaction: controlling the reactivity of a surface by light
Authors: Li Yuwen , Li Sen , Du Xin , Gu Zhongze
Published: June 2021

The interesting disulfide–alkyne chemistry provides the kinetics of the widely used thiol–alkyne chemical reaction.
Viscosity effect on the strategic kinetic overgrowth of molecular crystals in various morphologies: concave and octapod fullerene crystals
Authors: Song Kwangjin , Koo Jin Young , Choi Hee Cheul
Published: June 2021

A kinetic overgrowth allowing organic molecular crystals in various morphologies is induced by temperature-dependent viscosity change of crystallization solution.
Metal oxide/CeO2 nanocomposites derived from Ce-benzene tricarboxylate (Ce-BTC) adsorbing with metal acetylacetonate complexes for catalytic oxidation of carbon monoxide
Authors: Cai Dongren , Chen Bin , Huang Zhongliang , Zeng Xiaoli , Xiao Jingran , Zhou Shu-Feng , Zhan Guowu
Published: June 2021

Herein, a series of metal oxide/CeO2 (M/CeO2) nanocomposites derived from Ce-benzene tricarboxylate (Ce-BTC) adsorbing with different metal acetylacetonate complexes were prepared for CO oxidation.
Development of a structure-based computational simulation to optimize the blocking efficacy of pro-antibodies
Authors: Huang Bo-Cheng , Lu Yun-Chi , Liao Jun-Min , Liu Hui-Ju , Hong Shih-Ting , Hsieh Yuan-Chin , Chuang Chih-Hung , Chen Huei-Jen , Liao Tzu-Yi , Ho Kai-Wen , Wang Yeng-Tseng , Cheng Tian-Lu
Published: June 2021

The pro-Ab blocks the Ag binding site using an Ab lock. We designed a method which uses structure-based computational simulation (MSCS) to predict the cover rate of Ab locks with various linkers and select the suitable linker for each Ab.
Ion-pairing π-electronic systems: ordered arrangement and noncovalent interactions of negatively charged porphyrins
Authors: Sasano Yoshifumi , Tanaka Hiroki , Haketa Yohei , Kobayashi Yoichi , Ishibashi Yukihide , Morimoto Tatsuki , Sato Ryuma , Shigeta Yasuteru , Yasuda Nobuhiro , Asahi Tsuyoshi , Maeda Hiromitsu
Published: June 2021

π-Electronic ion pairs comprising porphyrin-based π-electronic anions have exhibited characteristic assembling modes and resulting electronic properties such as solid-state absorption and photoinduced electron transfer.
Multi-stimuli-responsive luminescent MCM48 hybrid for advanced anti-counterfeiting applications
Authors: de Azevedo Leandro A. , Gamonal Arturo , Maier-Queiroz Rosely , Silva Carolina S. , Ferro Jamylle N. S. , Oliveira Petrus d’Amorim S. C. , Barreto Emiliano O. , da Luz Leonis L. , Alves Júnior Severino
Published: June 2021

Two lanthanide complexes supported on MCM48 type silica have been synthetized to introduce a new concept of multi-stimuli responsive materials for anti-counterfeiting applications.
Correlated load forecasting in active distribution networks using Spatial‐Temporal Synchronous Graph Convolutional Networks
Authors: Yu Qun , Li Zhiyi
Published: June 2021

Load forecasting becomes increasingly challenging as power distribution networks evolve towards active distribution networks with high‐penetration renewables. In the context of active distribution networks, the load can be principally referred to as a mixture of power consumption devices as well as renewables‐based distributed energy resources behind the meters. Accordingly, more hidden information (e.g., correlations) should be mined from historical load observations to relieve the significant challenges resulting from behind‐the‐meter renewables. Here, a novel spatial‐temporal graph representation method is proposed to characterise and present spatial and temporal correlations of historical load observations. The graph‐structured data is then fed into a model denoted as Spatial‐Temporal Synchronous Graph Convolutional Network (STSGCN) for performing load forecasting by extracting the inherent spatial‐temporal features of historical load observations. Finally, numerical experiments are performed on a real‐world load dataset. The results show that the proposed method manages to capture spatial‐temporal correlations of load observations in the forecasting process while outperforming the state of the art in terms of overall forecasting accuracy.
Numerical simulation and experimental study of aeolian sand load under aeolian sand environment
Authors: Jia Ying , Yang Xueru
Published: June 2021

Concrete structures in a sandstorm environment suffer from sandstorm erosion for a long time, which reduces the durability of concrete buildings, and then threatens the safety of buildings. Therefore, it is of great practical significance to study the aeolian sand load under the aeolian sand environment. In this paper, by numerical simulation of the sand load on the surface of bridge and simulation test of the sand load on the surface of the concrete in the sand environment, the variation law of the sand load under different sand parameters is studied. Through comparative analysis, it is concluded that the variation law of aeolian sand load in numerical simulation and test tends to be consistent with the variation of aeolian sand velocity and sand content ratio.
Application of Ion Exchange Resin in the Advanced Treatment of Condensate Water
Authors: Li Xiaodan , Wu Shikun , Kan Chunlei , Zhang Ye , Liang Yingbin , Cui Guangzhi , Li Jiandong , Yang Songlin
Published: June 2021

The advanced treatment of condensate water is important for efficient reuse of water resources, especially in confined space. In this work, a novel integrated process of ion exchange resins and activated carbon is proposed to remove various pollutants in condensate water. A fixed bed column of pre-treated basic anion exchange resin, acidic cation exchange resin, mixed ion exchange resins and modified activated carbon was applied to remove ionic pollutants, organic pollutants and adjust the pH value of output water. The effects of the types, amount ratios and the sequence of ion exchange resins were investigated using two types of condensate water. The results showed that the output water of the fixed bed column had an average TOC of 30~70 ppm, conductivity under 5 μS/cm, pH value of 5~8, which could meet the requirements of sanitary water. The saturated adsorption capacities of the basic anion exchange resin and the acidic cation exchange resin were calculated to be 0.87 mol/L and 1.82 mol/L, respectively. Under the actual operating conditions, continuous dynamic test was carried out over a condensate water treatment module consisting of two adsorption columns and four exchange columns to evaluate its real service life.
Study on catalytic removal of toluene by metal oxides derived from hydrotalcite
Authors: Liu Hongbo , Huang Zhiyong
Published: June 2021

Hydrotalcite (HT) precursor was synthesized by coprecipitation method, and the surface of HT precursor was modified. The mixed metal oxide (MO) catalyst was prepared by calcination of HT precursor, which was used to remove toluene from VOCs assisted by NTP technology. The catalytic performance of MO catalyst was investigated. The results show that the MO catalyst with good structure can be obtained after calcination of HT precursor before and after modification. The results of catalytic performance test showed that the initial concentration of toluene was 700 ppm, the gas flow rate was 600 mL/min, and the reaction time was 30 min, SIE of NTP was above 3.0 kJ/L, the toluene conversion rate reached above 90%. MO assisted NTP had better catalytic performance with lower energy consumption. The toluene treatment capacity per unit energy consumption increased from 15.3% to 20.6%, which had an increase of 34.6%.
Simulation and Analysis of Building Energy Consumption in Port passenger Stations
Authors: Zheng Xuejing , Sun Qihang , Yang Xueqing , Liu Huzhen , Hu Fangshu , Sun Leizhai
Published: June 2021

Port passenger station buildings (PPSD) are an important part of transportation buildings in China, which is characterized by large human flow, long operating time, high load of equipment and lighting. The characteristics and functions of PPSD lead to the high energy consumption. However, the energy consumption analysis of PPSD was deficient. In this paper, the characteristics of energy consumption of port passenger stations in cold regions and hot summer and warm winter regions in China were analyzed. Based on eQUEST, the building models of port passenger stations are established. The influencing factors of the building energy consumption were analyzed through orthogonal experiment with SPSS. Results show that the factors such as summer indoor design temperature, heat source form, air conditioning form, window to wall ratio and lighting control mode are the key factors affecting the energy consumption of port passenger station.
Influence of different surface treatment on water penetration resistance of concrete
Authors: Li Tianlun , Wu Yonggen
Published: June 2021

Concrete is easily affected by all kinds of erosive substances during its use. Surface treatment is a simple method to improve the surface compactness and water permeability resistance of concrete. In this paper, silicate infiltration agent, nano-SiO2 and ethyl silicate are selected as concrete surface treatment material. The results of water permeability test showed that all the three treatments can effectively improve the water resistance. Silicate infiltration agent and nano-SiO2 were the most effective, which greatly reduced the penetration depth of water from 66 mm to 34mm and 32 mm, while ethyl silicate was reduced to 50 mm. Through the water permeability test curve, we can see that the water entered the concrete under a certain pressure, and the result showed the shape of high, middle and low edge.
Discussion on Calculation Method of Shear Bearing Capacity of HSC Beams Without Web Reinforcement under Concentrated Loads
Authors: Li Qingfu , Zhou Huade
Published: June 2021

In order to investigate the main influencing factors and development rules of the shear performance of high strength concrete (HSC) beams without web reinforcement under concentrated loads, analyze and compare the rationality of the China and American Code formulas and Zsutty formula, in this paper, 303 sets of experimental data about the shear test of HSC beams without web reinforcement at home and abroad were selected, based on these experimental data, the calculation method of the shear capacity of HSC beams without web reinforcement was discussed. The results showed that the measured shear bearing capacity of HSC beams without web reinforcement gradually increases with the decrease of the shear-span ratio. The nominal shear stress of HSC beams without web reinforcement gradually increases with the increase of concrete strength, the increase of longitudinal reinforcement ratio and the decrease of section height. The shear bearing capacity formula proposed by Zsutty is the most accurate prediction than other formulas. Based on the experimental data and considering the influence of the longitudinal reinforcement ratio on the shear bearing capacity of structure, a new calculation formula for the shear bearing capacity of HSC beams without web reinforcement under concentrated loads was obtained by regression analyze, and this formula is more comprehensive than the other three calculation formulas, moreover, the calculation results are more reasonable.
Discussion On The Optimization of Circumferential Distance Of The System Bolt In A Highway Tunnel
Authors: Wang Kun , Yu Shun , Pan Yong , Wang Lushi
Published: June 2021

The setting of circumferential distance of system anchor rod in highway tunnel is related to the safety of tunnel structure, and also affects the project cost. The “code for design of highway tunnels” issued in 2018 also adjusted the circumferential spacing arrangement of the system bolts of the tunnel. Based on a highway tunnel project, the circumferential spacing of system bolts in deep buried section of grade V surrounding rock is adjusted from 0.8m to 1.2m, and the numerical simulation and comparative analysis before and after the optimization of bolt spacing are carried out. The field monitoring and measurement data show that the surrounding rock deformation after adjustment has little effect, and the cavern is stable as a whole, which can guide the optimization implementation of subsequent sections.
Analysis on the Settlement of Adjacent Buildings Caused by the Underpassing Construction of the Biased Tunnel
Authors: Zhang Xu , Wang Dong , Wu Tong , Shi Zhenyue , Li Shaobo , Tian Yuanyuan , You Hongyue
Published: June 2021

Through the simulation analysis of the settlement and deformation law of the surface buildings caused by the construction of the biased tunnel, the following points are obtained: (1) The Peak formula is revised, and the influence range of the biased tunnel is predicted based on the formula. (2) It is concluded that when the tunnel is biased, the position of maximum deformation caused by ground settlement is generally in a parallel area 0.5 times the buried depth from the center line of the tunnel. (3) Through the double-layer verification of simulation analysis and monitoring measurement data, prior to the construction of buildings with similar weak foundations, their foundations should be reinforced in advance. (4) In the process of this simulation, the complicated influence of water pressure on tunnel excavation was not considered, which can be further optimized in the later stage.
Research on the Influence of Corporate Credit Culture on Corporate Financing Constraints--Panel data analysis based on A-share listed companies
Authors: Liu Zhiqiang , Zhou Lu
Published: June 2021

This paper takes China’s A-share listed companies from 2009 to 2019 as a sample, uses the mixed ols model and the two-way fixed effects model to conduct empirical analysis, and finds that when the corporate integrity culture is strong, the financing constraints faced by the company are lower. This conclusion remains robust after considering endogenous issues. This research not only explores ways to alleviate corporate financing constraints from a new perspective, but also has important practical significance for improving corporate governance and promoting the effective allocation of financial market resources.
Recent advances in novel functional nanomaterials-based oil/water separation techniques
Authors: Li Sen , Ji Yunzhe , Li Xiaojing , Wang Xiaojie
Published: June 2021

The increasing amount of oily wastewater discharges caused major challenges for current environmental issues, such as oil-water purification and separation [1-6]. Thus, the development of new functional materials for the efficient treatment of oil-water is imperative [7-11]. This paper reviewed the recently developed oil-water separation technologies, which were based on novel functional nanomaterials, and presented representative works in detail. Finally, the challenges and future research directions of this area were briefly discussed.
Academic leadership commences by self-leadership
Authors: Hamdoun Ali
Published: June 2021

Enhancing leaders and leadership are major elements when pursuing improvement of learning and teaching in the higher education sector. This study was conducted to investigate the self-leadership skills of the academic staff in the Lebanese higher education sector. It is stated that “an effective academic leader must be able to lead oneself effectively before he or she can lead others within and outside the classroom”. Through a survey, academic staff (instructors) were asked to rank selfleadership skills that they believe they possess and apply. This survey also presented questions that allowed the researcher to identify whether academics have a clear comprehension of this concept in Lebanese universities and what prevents them from attaining and applying them. The data collected was analyzed using SPSS. The findings indicated that the skills of self-leadership were not being applied effectively and the concept was not clearly comprehended by the Lebanese higher education institutions. Thus, it is recommended to train the academic staff to improve their knowledge, attitudes and skills regarding the concept of selfleadership and it presented potential strategies that facilitated sharing innovations to effectively apply such leadership and promote the importance of quality teaching experiences.
The Solar Activity Monitor Network – SAMNet
Authors: Erdélyi Robertus , Korsós Marianna B. , Huang Xin , Yang Yong , Pizzey Danielle , Wrathmall Steven A. , Hughes Ifan G. , Dyer Martin J. , Dhillon Vikram S. , Belucz Bernadett , Brajša Roman , Chatterjee Piyali , Cheng Xuewu , Deng Yuanyong , Domínguez Santiago Vargas , Joya Raúl , Gömöry Peter , Gyenge Norbert G. , Hanslmeier Arnold , Kucera Ales , Kuridze David , Li Faquan , Liu Zhong , Xu Long , Mathioudakis Mihalis , Matthews Sarah , McAteer James R.T. , Pevtsov Alexei A. , Pötzi Werner , Romano Paolo , Shen Jinhua , Temesváry János , Tlatov Andrey G. , Triana Charles , Utz Dominik , Veronig Astrid M. , Wang Yuming , Yan Yihua , Zaqarashvili Teimuraz , Zuccarello Francesca
Published: June 2021

The Solar Activity Magnetic Monitor (SAMM) Network (SAMNet) is a future UK-led international network of ground-based solar telescope stations. SAMNet, at its full capacity, will continuously monitor the Sun’s intensity, magnetic, and Doppler velocity fields at multiple heights in the solar atmosphere (from photosphere to upper chromosphere). Each SAMM sentinel will be equipped with a cluster of identical telescopes each with a different magneto-optical filter (MOFs) to take observations in K I, Na D, and Ca I spectral bands. A subset of SAMM stations will have white-light coronagraphs and emission line coronal spectropolarimeters. The objectives of SAMNet are to provide observational data for space weather research and forecast. The goal is to achieve an operationally sufficient lead time of e.g., flare warning of 2–8 h and provide many sought-after continuous synoptic maps (e.g., LoS magnetic and velocity fields, intensity) of the lower solar atmosphere with a spatial resolution limited only by seeing or diffraction limit, and with a cadence of 10 min. The individual SAMM sentinels will be connected to their master HQ hub where data received from all the slave stations will be automatically processed and flare warning issued up to 26 h in advance.
Dosismanagement – Neue Aufgaben für MTRA
Authors: Singer Julian
Published: June 2021

Auf Grundlage der Strahlenschutzgesetzgebung müssen umfassende Dosisdokumentationen vorgehalten werden. Moderne Dosismanagementsysteme unterstützen die Dokumentation und Analyse von medizinischen und beruflichen Strahlenexpositionen, um den rechtlichen Pflichten Folge zu leisten. Dieses zusätzliche Tätigkeitsfeld bietet MTRA neue Chancen zur beruflichen Weiterentwicklung und eine Flexibilisierung des Berufsalltags.
Quench im MRT: ein Phänomen der Kryophysik
Authors: Kühnast Wolfgang
Published: June 2021

Dieser Artikel beschreibt eine kryophysikalische Besonderheit der supraleitenden Magnete – den Quench – mit dem Ziel, dieses Phänomen besser zu verstehen. Idealerweise können die Ursachen, die zu einem Quench führen, vermieden werden. Für den Fall, dass es zu einem Quench kommen sollte, werden Tipps gegeben die richtigen Maßnahmen einzuleiten, um größere Beeinträchtigungen sowohl des Patienten als auch an der Technik zu vermeiden.
Radiopraxis - Verband der Radiologietechnologinnen und -technologen Österreichs Organ der VMTB, Vereinigung der Medizinisch-Technischen Berufe in der DRG
Authors: Knabl Michaela
Published: June 2021

Auch wenn uns alle die Pandemie voll im Griff hat, steht die Welt um uns herum nicht still.

Fortbildung ist ein wesentlicher Faktor in unserem Beruf und wird auch oft von der Medizintechnik getrieben. Gerade die Berufe der Radiologietechnologie sind ständigen Herausforderungen unterworfen – egal in welchem Staat – und daher ist es den Berufsverbänden ein großen Anliegen Fortbildung zu gestalten und zu ermöglichen.
Einsatz von PSMA-PET/CT beim Prostatakarzinom
Authors: Langbein Thomas , Eiber Matthias
Published: June 2021

In den letzten Jahren hat die PSMA-Liganden-PET vielversprechende Ergebnisse gezeigt und so enorm an Bedeutung bei der Versorgung von Prostatakarzinompatienten gewonnen. Dieser Beitrag soll einen Überblick zur PSMA-PET/CT in unterschiedlichen klinischen Situationen geben und auf aktuelle prospektive Studienergebnisse eingehen, welche den Stellenwert der PSMA-vermittelten Hybridbildgebung in den kommenden Jahren noch weiter steigern werden.
Multiparametrische quantitative Magnetresonanztomografie bei Lebererkrankungen
Authors: Haimerl Michael , Stroszczynski Christian , Senk Karin
Published: June 2021

Die MRT wird routinemäßig bei Patienten mit einer Erkrankung der Leber zum Ausschluss oder zur Verlaufskontrolle einer strukturellen Parenchymveränderung eingesetzt. Durch spezielle MRT-Sequenzen und -Techniken lassen sich Eigenschaften der Leber bezüglich Funktion, Fibrosestadium, Fett- und Eisengehalt quantifizieren. Die MRT hilft sowohl bei der ersten Diagnostik eines Krankheitsbildes als auch bei der überprüfung des Therapieansprechens.
Management des Vorhofflimmerns: Prognoseverbesserung nach Pulmonalvenenisolation?
Authors: Hartmann Jens , Gunawardene Melanie , Jularic Mario , Eickholt Christian , Willems Stephan
Published: June 2021

Vorhofflimmern ist die weltweit häufigste, anhaltende Herzrhythmusstörung. Trotz des
Fortschritts und der Innovationen im Management der betroffenen Patienten bleibt
Vorhofflimmern mit einer signifikanten Morbidität und Mortalität, bedingt durch das Auftreten
von unter anderem thrombembolischen Ereignissen, Herzinsuffizienz, kardiovaskulären
Ereignissen und plötzlichem Herztod, vergesellschaftet. Es konnte kürzlich gezeigt werden,
dass eine frühzeitige rhythmuserhaltende Therapie das Risiko für einen Tod durch
kardiovaskuläre Ursache, Schlaganfälle und Hospitalisierungen aufgrund von Herzinsuffizienz
reduzieren kann. Die Katheterablation von Vorhofflimmern ist zwar effektiver in der
Wiederherstellung und Erhaltung von Sinusrhythmus als eine medikamentöse Therapie, aber
lediglich in spezifischen Patientengruppen, die von Herzinsuffizienz und Vorhofflimmern
betroffen sind, konnte die Ablationsbehandlung mit einer Reduktion der Gesamtmortalität und von
Hospitalisierungen assoziiert werden.
Antikoagulation nach Pulmonalvenenisolation bei Patienten mit CHA2DS2-Vasc von ≤ 2: nur passager oder dauerhaft?
Authors: Kochhäuser Simon , Riesinger Lisa
Published: June 2021

Die Verhinderung von thrombembolischen Ereignissen durch eine risikoadjustierte Antikoagulation ist eine der wichtigsten Säulen in der Therapie von Vorhofflimmern. Durch eine Katheterablation kann in einer zunehmenden Anzahl von Fällen eine langfristige Beschwerdefreiheit erzielt werden und die Häufigkeit und Dauer von Vorhofflimmerepisoden stark gesenkt werden oder sogar komplett unterdrückt werden. Trotzdem konnte bislang keine signifikante Senkung des Schlaganfallrisikos durch eine Katheterablation nachgewiesen werden. Daher besteht weiterhin die eindeutige Empfehlung auch nach einer erfolgreichen Katheterablation, die Antikoagulation in Abhängigkeit vom individuellen Risiko dauerhaft fortzusetzen. Aktuell laufende Studien und neue Technologien werden es in Zukunft möglicherweise erlauben, Patienten mit einem niedrigen Schlaganfallrisiko nach Ablation zu identifizieren, bei denen eine Beendigung der Antikoagulation sicher ist.