bluuebunny/crossref_metadata_2025 huggingface dataset:
SICOPOLIS-AD v1: an open-source adjoint modeling framework
for ice sheet simulation enabled by the algorithmic differentiation
tool OpenAD
Authors: Logan Liz C. , Narayanan Sri Hari Krishna , Greve Ralf , Heimbach Patrick
Published: August 2019

Abstract. We present a new capability of the ice sheet model SICOPOLIS that enables flexible adjoint code generation via source transformation using the open-source algorithmic differentiation (AD) tool OpenAD. The adjoint code enables efficient calculation of sensitivities of a scalar-valued objective function or quantity of interest (QoI) to a range of important, often spatially varying model input variables, including initial and boundary conditions, as well as model parameters. Compared to earlier work on adjoint code generation of SICOPOLIS, our work is based on several important advances: (i) it is embedded within the up-to-date trunk of the SICOPOLIS repository – accounting for one and a half decades of code development and improvements – and is readily available to the wider community; (ii) the AD tool used, OpenAD, is an open-source tool; (iii) the adjoint code developed is applicable to both Greenland and Antarctica, including grounded ice as well as floating ice shelves, and with an extended choice of thermodynamical representations. A number of code refactorization steps were required. They are discussed in detail in an Appendix as they hold lessons for application of AD to legacy codes at large. As an example application, we examine the sensitivity of the total Antarctic Ice Sheet volume to changes in initial ice thickness, summer precipitation, and basal and surface temperatures across the ice sheet. Simulations of Antarctica with floating ice shelves show that over 100 years of simulation the sensitivity of total ice sheet volume to the initial ice thickness and precipitation is almost uniformly positive, while the sensitivities to surface and basal temperature are almost uniformly negative. Sensitivity to summer precipitation is largest on floating ice shelves from Queen Maud to Queen Mary Land. The largest sensitivity to initial ice thickness is at outlet glaciers around Antarctica. Comparison between total ice sheet volume sensitivities to surface and basal temperature shows that surface temperature sensitivities are higher broadly across the floating ice shelves, while basal temperature sensitivities are highest at the grounding lines of floating ice shelves and outlet glaciers. A uniformly perturbed region of East Antarctica reveals that, among the four control variables tested here, total ice sheet volume is most sensitive to variations in summer precipitation as formulated in SICOPOLIS. Comparison between adjoint- and finite-difference-derived sensitivities shows good agreement, lending confidence that the AD tool is producing correct adjoint code. The new modeling infrastructure is freely available at www.sicopolis.net under the development trunk.
BESS-STAIR: a framework to estimate daily, 30-meter, and allweather crop evapotranspiration using multi-source satellite data for the U.S. Corn Belt
Authors: Jiang Chongya , Guan Kaiyu , Pan Ming , Ryu Youngryel , Peng Bin , Wang Sibo
Published: August 2019

Abstract. With increasing crop water demands and drought threats, mapping and monitoring of cropland evapotranspiration (ET) at high spatial and temporal resolutions becomes increasingly critical for water management and sustainability. However, estimating ET from satellite for precise water resources management is still challenging due to the limitations in both existing ET models and satellite input data. Specifically, the process of ET is complex and difficult to model, and existing satellite remote sensing data could not fulfill high resolutions in both space and time. To address the above two issues, this study presented a new high spatiotemporal resolution ET mapping framework, i.e., BESS-STAIR, which integrates a satellite-driven water-carbon-energy coupled biophysical model BESS (Breathing Earth System Simulator) with a generic and fully-automated fusion algorithm STAIR (SaTallite dAta IntegRation). In this framework, STAIR provides daily 30-meter multispectral surface reflectance by fusing Landsat and MODIS satellite data to derive fine-resolution leaf area index and visible/near-infrared albedo, all of which, along with coarse-resolution meteorological and CO2 data, are used to drive BESS to estimate gap-free 30-m resolution daily ET. We applied BESS-STAIR from 2000 through 2017 in six areas across the U.S. Corn Belt, and validated BESS-STAIR ET estimations using flux tower measurements over 12 sites (85 site-years). Results showed that BESS-STAIR daily ET achieved an overall R2 = 0.75, with RMSE = 0.93 mm d−1 and relative error = 27.9 % when benchmarked with the flux measurements. In addition, BESS-STAIR ET estimations well captured the spatial patterns, seasonal cycles, and interannual dynamics in different sub-regions. The high performance of the BESS-STAIR framework is primarily resulted from: (1) the implementation of coupled constraints on water, carbon, and energy in BESS, (2) high-quality daily 30-m data from STAIR fusion algorithm, and (3) BESS’s applicability under all-sky conditions. BESS-STAIR is calibration-free and has great potentials to be a reliable tool for water resources management and precision agriculture applications for the U.S. Corn Belt, and even for worldwide given the global coverage of its input data.
Review of fragility analyses for major building types in China
with new implications for intensity-PGA relation development
Authors: Xin Danhua , Daniell James Edward , Wenzel Friedemann
Published: August 2019

Abstract. The evaluation of the seismic fragility of buildings is one key task of earthquake safety and loss assessment. Many research reports and papers have been published over the past four decades that deal with the vulnerability of buildings to ground motion caused by earthquakes in China. We first scrutinized 69 papers and theses studying building damage for earthquakes occurred in densely populated areas. They represent observations where macro-seismic intensities have been determined according to the Chinese Official Seismic Intensity Scale. From these many studies we derived the median fragility functions (dependent on intensity) for four damage limit states of two most widely distributed building types: masonry and reinforced concrete. We also inspected 18 publications that provide analytical fragility functions (dependent on PGA) for the same damage classes and building categories. Thus, a solid fragility database based on both intensity and PGA is established for seismic prone areas in mainland China. A comprehensive view of the problems posed by the evaluation of fragility for different building types is given. Necessary comparison with international projects with similar focus is conducted. Based on the newly collected fragility database, we propose a new approach in deriving intensity-PGA relation by using fragility as the bridge and reasonable intensity-PGA relations are developed. This novel approach may shed light on new thought in decreasing the scatter in traditional intensity-PGA relation development, i.e., by further classifying observed macro-seismic intensities and instrumental ground motions based on difference in building seismic resistance capability.
Non-Gaussian statistics in global atmospheric dynamics: a study with a 10 240-member ensemble Kalman filter using an intermediate atmospheric general circulation model
Authors: Kondo Keiichi , Miyoshi Takemasa
Published: August 2019

Abstract. We previously performed local ensemble transform Kalman filter (LETKF)
experiments with up to 10 240 ensemble members using an intermediate
atmospheric general circulation model (AGCM). While the previous study
focused on the impact of localization on the analysis accuracy, the present
study focuses on the probability density functions (PDFs) represented by the
10 240-member ensemble. The 10 240-member ensemble can resolve the detailed
structures of the PDFs and indicates that non-Gaussianity is caused in those
PDFs by multimodality and outliers. The results show that the spatial
patterns of the analysis errors are similar to those of non-Gaussianity.
While the outliers appear randomly, large multimodality corresponds well
with large analysis error, mainly in the tropical regions and storm track
regions where highly nonlinear processes appear frequently. Therefore, we
further investigate the life cycle of multimodal PDFs, and show that they
are mainly generated by the on–off switch of convective
parameterization in the tropical regions and by the instability associated
with advection in the storm track regions. Sensitivity to the ensemble size
suggests that approximately 1000 ensemble members are necessary in the
intermediate AGCM-LETKF system to represent the detailed structures of
non-Gaussian PDFs such as skewness and kurtosis; the higher-order
non-Gaussian statistics are more vulnerable to the sampling errors due to a
smaller ensemble size.
Seismic attenuation and dispersion in poroelastic media with fractures of variable aperture distributions
Authors: Lissa Simón , Barbosa Nicolás D. , Rubino J. Germán , Quintal Beatriz
Published: August 2019

Abstract. Considering poroelastic media containing periodically distributed parallel fractures, we numerically quantify the effects that fractures with variable aperture distributions have on seismic wave attenuation and velocity dispersion due to fluid pressure diffusion (FPD). To achieve this, realistic models of fractures are generated with a stratified percolation algorithm which provides statistical control over geometrical fracture properties such as density and distribution of contact areas. The results are sensitive to both geometrical properties, showing that an increase in the density of contact areas as well as a decrease in their correlation length reduce the effective seismic attenuation and the corresponding velocity dispersion. Moreover, we demonstrate that if equivalent physical properties accounting for the effects of contact areas are employed, simple planar fractures can be used to emulate the seismic response of fractures with realistic aperture distributions. The excellent agreement between their seismic responses was verified for all wave incidence angles and wave modes.
The Interaction of Market Risk and Idiosyncratic Risk on Equity Mutual Fund Returns
Authors: Murugesu John , Sakaran Chandra
Published: August 2019

This study examines the importance of idiosyncratic and systematic risks in explaining equity fund returns in Malaysia. The level of market and idiosyncratic risk in a mutual fund depends on what asset class it invests in. Equity type asset classes are exposed to both systematic and idiosyncratic risk but research generally suggest that only systematic risk is relevant in mutual fund selection since idiosyncratic risk can be reduced through fund diversification. This study attempts to expand the insights of the risk-return relationship by providing additional evidence on the direct and indirect effects of investment risk on equity mutual fund returns. Employing partial least squares structural equation modelling (PLS-SEM), we also explore if idiosyncratic risk moderates the relationship between market risk and mutual fund returns. A sample of 150 Malaysian domestic equity mutual funds comprising of large, mid & small-cap equity funds were selected from the Morningstar website.  The results indicate that market risk does not influence mutual funds returns but idiosyncratic risk has a significant and positive effect. Idiosyncratic risk is proxied by fund characteristics comprising of size, age, expenses and fund manager ability. This study shows that fund size, age or expenses are not significant and only the fund alpha which measures fund manager ability is relevant in predicting fund returns. The study also finds that the fund alpha moderates the influence of market risk on returns by changing the nature of the relationship from positive to negative.
Os Odontoideum in Children
Authors: Hedequist Daniel J. , Mo Andrew Z.
Published: August 2019

Os odontoideum is a rare entity of the second cervical vertebra, characterized by a circumferentially corticated ossicle separated from the body of C2. The ossicle is a distinct entity from an odontoid fracture or a persistent ossiculum terminale. The diagnosis may be made incidentally on imaging obtained for the workup of neck pain or neurologic signs and symptoms. Diagnosis usually can be made with plain radiographs. MRI and CT can assess spinal cord integrity and C1-C2 instability. The etiology of os odontoideum is a topic of debate, with investigative studies supporting both congenital and traumatic origins. A wide clinical range of symptoms exists. Symptoms may present as nondescript pain or include occipital-cervical pain, myelopathy, or vertebrobasilar ischemia. Asymptomatic cases without evidence of radiologic instability are typically managed with periodic observation and serial imaging. The presence of atlantoaxial instability or neurological dysfunction necessitates surgical intervention with instrumentation and fusion for stability.
Eerder verbindend dan visionair
Authors: Bastiaans Ineke , Karsten Niels
Published: August 2019

Bridging and bonding rather than visionary – An analysis of mayors' considerations in the use of their executive powers of the 'Damocles Law'

Several authors fear that the expansion of Dutch mayors’ executive powers in the field of safety and security will harm their position as non-partisan and consensus-oriented leaders. Empirical research into how mayors use their powers, however, is still rare. From a leadership perspective, the current article analyzes how mayors in the region of South East Brabant in Netherlands use their administrative power to close homes involved in drug-related crime. Drawing on Fischer’s framework of discursive practices, we analyze mayors’ considerations in terms of the argumentation they provide for closing homes. Our analysis, which draws on interviews and document analysis, covers 27 cases from the police region of South-East Brabant and includes 120 considerations. Our findings indicate that mayors vindicate home closures mostly through policy-derived technical and situational argumentations. Vindications that aspire a particular societal effect, such as the reduction of criminal activity, or ideological motivations are rarer, which is indicative of a non-decisive leadership style. In addition, mayors mostly respect the local closure policies. As such, they show very little decisive and individualistic leadership. And, to the extent that they deviate from agreed-upon regional policies, their motivation is to be able to take into account unique local circumstances. In the use of their administrative powers mayors, thus, show mostly situational and adaptive leadership, which, rather than as visionaries, positions them as caretakers. The leadership style of Dutch mayor in the use of this administrative power is, thus, much more in accordance with their traditional bridging-and-bonding leadership style than some authors suspect. Some of the limitations of our study are that we have analyzed closure decisions from one region only and that real-life decisions are susceptible to contextual influences. At the same time, our study provides a rare insight into real-world mayoral leadership in the Netherlands in the field of safety and security.
Rede Neural Convolucional para o Diagnóstico de Leucemia
Authors: Vogado Luis H. S. , Veras Rodrigo M. S. , Araujo Flavio H. D. , Silva Romuere R. V. , Aires Kelson R.T.
Published: August 2019

A leucemia é um tipo de câncer que afeta a produção de células san- guíneas na médula óssea o que dificulta a coagulação do sangue e o combate a infecções. Nesse trabalho propomos um método para o diagnóstico automático de leucemia utilizando Redes Neurais Convolucionais (CNNs). Nós utilizamos CNNs pré-treinadas e técnicas de transferência de aprendizagem na constru- ção do método proposto. Empregamos a técnica Deeply Fine Tuning Modi- fied (DFTM) combinada com operações de aumento de dados para refinar um modelo pré-treinado. Para treinar e testar o método proposto, utilizamos um conjunto de 2304 imagens de 14 bases diferentes. O método proposto atingiu acurácia de 98,84% e quando comparado com outros trabalhos, observamos maior robustez e consistência nos resultados. Ao final, concluímos que o ajuste fino é mais robusto a classificação de imagens heterogêneas quando comparado com a extração de características através de CNNs.
Um Modelo Sensı́vel ao Contexto para Avaliação da Saúde Mental por meio da Variabilidade da Frequência Cardı́aca
Authors: Bavaresco Rodrigo Simon , Barbosa Jorge Luis  Victória
Published: August 2019

O método tradicional de avaliação da saúde mental, realizado nor- malmente por um psicoterapeuta, mostra ı́ndices de imprecisão relevantes. Este trabalho apresenta o modelo RevitalMe, que analisa a frequência cardı́aca a fim de contribuir ao método tradicional. O modelo proporciona ao psicoterapeuta informações do dia a dia do indivı́duo, estabelecendo uma correlação entre a saúde mental e os lugares frequentados, por meio da sensibilidade ao contexto. A avaliação do modelo foi realizada com a implementação e uso de um protótipo aplicado ao estresse, que apresenta F1-Score de 88% na classificação do estado do indivı́duo entre “estressado” e “não estressado”. A utilidade percebida do modelo é de 83% de acordo com 5 psicoterapeutas.
Estudo e Implementação de um Sistema Customizável para Controle Laboratorial para o Processo de Tipificação HLA
Authors: Silva Marcio N.P. , Pôrto Luís Cristóvão M. S. , Marzulo Leandro A.J. , Sena Alexandre  C.
Published: August 2019

Uma compatibilidade favorável entre doador/receptor diminui con- sideravelmente a chance de rejeição em transplantes. Nos humanos o grupa- mento gênico do DNA responsável pelo sistema imune é denominado HLA. Tes- tes laboratoriais foram desenvolvidos para identificar esse grupamento e um deles é a tipificação HLA. Essas avaliações precisam ser realizadas por labo- ratórios especializados e nesse contexto o Laboratório de Histocompatibilidade e Criopreservação da Universidade do Estado do Rio de Janeiro (HLA-UERJ) tem posição de destaque no setor. O processo como um todo é complexo e ex- tenso, envolvendo diversas equipes e setores do laboratório, com uma intensa troca de informações. Os dados tratados são extremamente importantes o que demanda um rı́gido controle para garantir a rastreabilidade e confiabilidade dos resultados. Nesse contexto, o objetivo deste trabalho é mapear todo o pro- cesso de tipificação HLA e apresentar e implementar um sistema customizável para gerenciamento de processos laboratoriais.
Utilizando Análise Espacial na Identificação dos Territórios de Unidades Básicas de Saúde e sua Correlação com Casos de Hanseníase
Authors: Baia Marcos J.S. , Conde Guilherme A. B. , Conde Valney Mara G.
Published: August 2019

Objetivo deste trabalho foi realizar a correlação entre a cobertura e abrangência das Unidades Básicas de Saúde (UBS), com a distribuição espacial dos casos de hanseníase no município hiperendêmico de Santarém região oeste do estado do Pará. A metodologia utilizada para a realização deste estudo, foi o mapeamento das coberturas territorial das UBS, da sua abrangência, ou seja, a área de atuação dos Agentes Comunitários de Saúde (ACS) e os casos de Hanseníase do período de 2003 a 2013, para isso utilizou- se um Sistema de Informação Geográfica (SIG) para a visualização da distribuição espacial dos casos de hanseníase em relação à cobertura e abrangência da UBS no município. Tivemos como resultado os desenvolvimentos de shapefiles da cobertura e abrangência da UBS e a distribuição dos casos de hanseníase. Por meio do uso da análise espacial foram identificadas as áreas descobertas pelas UBS, bem como a distribuição espacial dos casos de Hanseníase.
Balanceamento Automático de Metas para Estabilização de Indicadores de Saúde na Atenção Básica
Authors: Veras Nécio De Lima , Viana Windson , Da Silva Mizael Lima , Júnior Ely Bezerra Silva
Published: August 2019

O planejamento de serviços orientados por metas para indicadores de saúde promove a melhoria do acesso e da qualidade da oferta desses serviços. Um balanceamento automático de metas objetiva melhorar a aproximação dos indicadores em relação ao valor originalmente planejado em cenários incons- tantes. Neste contexto, este artigo formaliza o balanceamento automático de metas, incorporando-o em uma ferramenta capaz de simular cenários contin- gentes que desviam de um plano inicial. Os resultados estatı́sticos do uso da proposta, a partir de simulações inspiradas em cenários realistas, são satis- fatórios e ofereceram valores positivos (p < 0, 05), sugerindo que a abordagem poderia funcionar corretamente em um ambiente real.
HealthDash: Monitoramento remoto de pacientes utilizando programação baseada em fluxo de dados
Authors: Celestrini Jordano R. , Rocha Renato N. , Santos Celso A. S. , Mota Vinícius F. S. , Filho José G. Pereira , Andreão Rodrigo V.
Published: August 2019

Neste artigo, propomos o HealthDash, um arcabouço para o desen- volvimento de soluções IoT para saúde. O HealthDash emprega o paradigma de programação orientado a fluxo de dados, desde camada cloud à borda da rede (camada fog), unificando tecnologias de desenvolvimento em todas as ca- madas, isto é, dos dispositivos de borda à tomada de decisão. Para validar a proposta, foi conduzido um experimento que simulou a transmissão de da- dos de pacientes crônicos monitorados em domicı́lio, considerando dois modos de envio: transmissão contı́nua de dados e transmissão de dados baseada em eventos. O experimento mostrou que a solução proposta fornece infraestrutura flexı́vel, consumindo menos largura de banda e menos tempo de resposta.
Projeto QuizTEA - Desenvolvendo Quiz Digitais para Indivı́duos Portadores do Transtorno do Espectro Autista
Authors: Gomes Victória O. , Aguiar Ellen C. , Sarinho Victor T.
Published: August 2019

O Transtorno do Espectro Autista (TEA) prejudica a transmissão de conhecimento de seus portadores, transformando o aprendizado dos mesmos em um processo demorado e laborioso. Assim, para dar suporte ao desenvol- vimento de aspectos sociais e da linearidade de acontecimentos de portadores do TEA, este trabalho apresenta o desenvolvimento do QuizTEA. Trata-se de jogo digital que será desenvolvido no formato de quiz digital, onde, após ouvir uma história, o jogador deverá responder as perguntas de forma a ordenar os quadrinhos que contam a história ouvida.
Methods for Breathing Rate Measurement through Mobile Platform: a Review
Authors: Lemos Diego O. , Siebra Clauirton A.
Published: August 2019

Breathing rate is a vital sign that can indicate someone’s health status and even detect early diseases. Mobile health applications might become the main tool for estimating breathing rate out of the clinical environment. In this research, a review of the literature is conducted, aiming at finding out the most recent researches that have been proposed as solutions for respiratory measurement or monitoring using mobile devices. We discuss and compare their methods, highlighting pros and cons regarding ubiquity and feasibility. The results indicate that the combination of methods is a key aspect to improve measurements.
Aedes na Mira 2.0 - Um Jogo Baseado em Realidade Virtual para Prevenção e Combate ao Mosquito Aedes Aegypti
Authors: Miguel Álan B. R. , Sarinho Victor T.
Published: August 2019

A população brasileira vem sofrendo continuamente com o quadro de pessoas infectadas por doenças provenientes do mosquito Aedes aegypti, as quais apresentam alternâncias de surtos e epidemias de difı́cil combate, tendo levado a óbito centenas de pessoas ano após ano. Este trabalho apresenta os resultados obtidos com o desenvolvimento do Aedes na Mira 2.0, um jogo que aplica mecânicas e dinâmicas de realidade virtual em um cenário capaz de proporcionar um contexto de aprendizagem na prevenção e no combate ao res- pectivo mosquito.
On Using Image Processing Techniques for Evaluation of Mammography Acquisition Errors
Authors: Moran Maira B. H. , Conci Aura , Rêgo Salete De J.F. , Fontes Cristina A. P. , Faria Marcelo D. Brito , Bastos Luciana Freitas , Giraldi Gilson A.
Published: August 2019

A mamografia é um exame extremamente importante, considerando a alta incidência de doenças relacionadas à mama, uma vez que ajuda a detectar várias anormalidades. Erros na aquisição podem mascarar possı́veis proble- mas. O objetivo deste estudo é aplicar técnicas de processamento de imagens para detectar automaticamente alguns erros muito comuns. As visualizações dos mamogramas craniocaudais (CC) e oblı́quos mediolaterais (MLO) fo- ram avaliadas considerando aspectos como: (1) posicionamento simétrico da mama, (2) correto perfilamento e centralização dos mamilos e (3) localização adequada do músculo peitoral. As técnicas de processamento de imagem utili- zadas baseiam-se na esqueletização da Morfologia Matemática, transformação de Hough e limiarização após uma etapa de pré-processamento. Os resultados obtidos são muito bons, especialmente na determinação da posição do mamilo.
SemanticSUS: Um Portal Semântico baseado em Ontologias e Dados Interligados para Acesso, Integração e Visualização de Dados do SUS
Authors: Da Cruz Matheus Mayron Lima , Avila Caio Viktor Silva , Vidal Vânia Maria Ponte , Arruda Junior Narciso Moura
Published: August 2019

Esta demo apresenta SemanticSUS, um portal semântico para acesso, análise e visualização de grande quantidade de dados do Sistema Único de Saúde (SUS). O Portal SemanticSUS é baseado em um enfoque que combina on- tologias e Dados Interligados para enfrentar os desafios no desenvolvimento de aplicações onde existe a necessidade de integrar fontes de dados heterogêneas. O SemanticSUS tem como principal objetivo oferecer uma camada ontológica, conectada semanticamente aos dados, e que permita o acesso integrado aos dados. A plataforma disponibiliza também o serviço de integração semântica baseado na abordagem “pay-as-you-go”, o que garante flexibilidade e exten- sibilidade suficientes para que novas fontes de dados possam ser adicionadas ao portal. Outra facilidade do portal é a ferramenta “Mashup Buider”, a qual permite a construção de Mashup de Dados de forma simples e automática.
STH – Sistema Teleatendimento Holográfico: Um sistema de videoconferência para o Sistema de Saúde Holográfico da UFF
Authors: Fonseca André Luis De Oliveira , Fernandes Natalia Castro , Carrano Ricardo Campanha
Published: August 2019

Este artigo apresenta a ferramenta de controle e gerência desenvol- vida para o sistema de telepresença por videocolaboração para teleintercon- sultas médicas com holografia da UFF. O principal foco do sistema é prover atendimento médico especializado a locais remotos através de transmissão bi- direcional com streaming de áudio e vídeo, seja meio físico terrestre ou via satélite, dependendo da infra-estrutura disponível. A ferramenta desenvolvida é adaptada ao ambiente com projeção holográfica e amigável para a completa operação do sistema pelas equipes de saúde. Com sua arquitetura modular, per- mite a inserção de novos sensores médicos de forma simples, além de atender aos requisitos impostos pela legislação, com relação à transmissão e ao armaze- namento seguro dos dados. O sistema foi testado com diferentes especialidades médicas, tendo sido muito bem aceito pelos profissionais de saúde.
SÊNTIMUS: um Jogo Digital Musical para Crianças com Hipersensibilidade Sonora e Caracterı́sticas dos Transtornos do Neurodesenvolvimento
Authors: Gomes Débora Line , Loureiro Cybelle , Prates Raquel
Published: August 2019

Este trabalho apresenta a pesquisa envolvida no projeto e avaliação do Sêntimus: um Jogo Digital Musical para Crianças com Hipersensibilidade Sonora e Caracterı́sticas dos Transtornos do Neurodesenvolvimento. Para sua elaboração identificamos na literatura princı́pios relevantes para o tratamento de ambas as patologias. As avaliações foram realizadas com 5 musicotera- peutas e com 3 crianças com Transtornos do Neurodesenvolvimento e Hiper- sensibilidade Sonora. Nosso trabalho traz contribuições para a pesquisa sobre jogos sérios, e também de natureza prática, uma vez que o Sêntimus pode ser apropriado para o apoio ao tratamento da população alvo.
Uma Proposta de Incubadora Multissensorial para Neonatos: Das Práticas Médicas com o Robô Premature Anne às Possibilidades de Transformação em Produto de Baixo Custo
Authors: Reche Letícia De Almeida , Dos Santos Junior João Benedito , Soares Júlia Pereira , Da Silveira Norma Ávila , Maia Núbia Samara , Bonfim Thatia Regina , De Oliveira Mayra Loures
Published: August 2019

Este trabalho apresenta uma proposta de protótipo de Incubadora Neonatal Multissensorial, para fins acadêmicos e eventual uso em ambiente hospitalar. No caso de uso em ambientes acadêmicos, pretende-se melhorar a qualidade do aprendizado de estudantes de Medicina e demais cursos da área de Saúde, oferecendo um ambiente bastante realístico, quando comparado ao ambiente que muitos médicos encontram nas situações cotidianas de atendimento a recém-nascidos. No caso de uso em ambientes hospitalares, pretende-se chegar à construção de um equipamento de baixo custo, porém eficiente e confiável, que possa ser aplicado para reduzir o déficit de incubadoras para recém-nascidos existente no Brasil. O protótipo é desenvolvido de forma multidisciplinar, com alunos e professores dos cursos de Medicina e Ciência da Computação, usufruindo dos recursos e funcionalidades de simulação oferecidos pelo robô-manequim Premature Anne.
Diet and hair loss: effects of nutrient deficiency and supplement use
Authors: Guo Emily L. , Katta Rajani
Published: August 2019

Patients presenting with hair loss should be screened by medical history, dietary history and physical exam for risk factors for nutrient deficiency. If warranted, laboratory studies may be performed. In patients with no risk factors, further laboratory evaluation searching for nutritional deficiencies is not warranted. For patients with nutritional deficiencies, it is clear that those deficiencies should be corrected. Further research is required to determine whether any benefit exists for nutrient supplementation in the absence of documented deficiency. At this time, patients must be informed that such research is lacking and that in fact some supplements carry the risk of worsening hair loss or the risk of toxicity.
Onychoscopy: an observational study in 237 patients from the Kashmir Valley of North India
Authors: Bhat Yasmeen Jabeen , Mir Muzafar Ahmad , Keen Abid , Hassan Iffat
Published: August 2019

Background: Nail disorders comprise approximately10% of all dermatological conditions. Because diagnosis is not always possible by clinical means alone, additional diagnostic procedures may be required at times. Dermoscopy of nails (onychoscopy) has shown promising results in diagnosing various nail disorders and also avoids time-consuming investigations such as culture and biopsy.

Objective: To study the dermoscopic features of various nail disorders to determine the correlation between KOH examination and onychoscopic patterns in patients with the clinical suspicion of onychomycosis, and to differentiate benign pigmented lesions from malignant ones.

Methods: An open, observational and cross-sectional study of 237 patients was conducted. All patients underwent clinical examination and the affected nails were examined with a dermatoscope. The onychoscopic patterns were identified and recorded.

Results: The study included 237 patients with the following diagnoses: 81 onychomycosis, 63 psoriasis, 27 lichen planus, 30 longitudinal melanonychia, 24 connective tissue disorders, 5 onychophagia and nail tics, 3 subungual verrucae, 2 glomus tumor, 1 Darier disease, and 1 enchondroma. The most common onychoscopic findings were spiked pattern in cases of onychomycosis, dilated and tortuous capillaries in cases of psoriasis, longitudinal streaks and nail fragmentation in cases of lichen planus, and enlarged capillaries in cases of connective tissue diseases.

Limitations: The study was only observational and did not compare the results to biopsy and culture.

Conclusions: Onychoscopy may be used as an important diagnostic tool when evaluating nail disorders. It should be used to aid in the diagnosis of various nail disorders and to avoid unnecessary and time-consuming investigations.
The Verbal-Kinesic Enactment of Contrast in North American English
Authors: Hinnell Jennifer ,   Semiotic Society of America
Published: August 2019

In this paper, I explore the linguistic and kinesic expression of contrast—the pitting of one position, object, or idea, against another. The archetype utterance for the embodied expression of contrast in English is the bipartite construction On the one hand . . . . On the other hand . . . . in which hand gestures are often performed sequentially along the sagittal axis (first on one side and then on the other side of the body) to depict the two options. However, English speakers have a variety of other linguistic means available to them for expressing contrast. Using data from naturally occurring discourse, I describe a range of linguistic resources that mark contrast and examine the semiotic relationships at play in the dynamic, multimodal signs (i.e. speech / gesture constructions) that accompany them. I demonstrate that, far from being ad hoc, when analyzed across the propositional, cognitive, and discursive domains, the way in which contrast is marked in the body can be viewed on a continuum of highly imageable to more schematically iconic kinesic movements. By placing the primary focus on the multimodal sign, this paper makes clear how speakers of North American English build semiotic environments around the construal of contrast.
Teaching Critical Thinking Virtues and Vices
Authors: Hanscomb Stuart ,   Philosophy Documentation Center
Published: August 2019

In the film and play Twelve Angry Men, Juror 8 confronts the prejudices and poor reasoning of his fellow jurors, exhibiting an unwavering capacity not just to formulate and challenge arguments, but to be open-minded, stay calm, tolerate uncertainty, and negotiate in the face of considerable group pressures. In a perceptive and detailed portrayal of a group deliberation a ‘wheel of virtue’ is presented by the characters of Twelve Angry Men that allows for critical thinking virtues and vices to be analysed in context. This article makes the case for (1) the film being an exceptional teaching resource, and (2), drawing primarily on the ideas of Martha Nussbaum concerning contextualised detail, emotional engagement, and aesthetic distance, its educational value being intimately related to its being a work of fiction.
Grants
Authors: Library Association American
Published: August 2019

Grants
Acquisitions
Authors: Thompson Hugh
Published: August 2019

Acquisitions
Management options for addressing the persistent and unresolved CITES issue of Madagascar’s rosewood stocks and stockpile
Authors: Wilmé Lucienne , Innes John L. , Schuurman Derek , Ramamonjisoa Bruno , Langrand Marion , Barber Charles V. , Butler Rhett A. , Wittemyer George , Waeber Patrick O.
Published: August 2019

Stocks and stockpiles of CITES (the Convention on International Trade in Endangered Species of wild fauna and flora) listed wildlife, including animal and plant-derived products, remain a complex, unresolved issue. The biggest challenges lie in the prevention of further illegal sourcing of—and trade in—products originating from wild populations of threatened species. Stocks can function as a buffer during lean periods or as a mechanism used for speculation. As we outline in this paper, the current situation in Madagascar precludes non-detriment findings intended to enable sustainable use of standing rosewood populations. Backed by the World Bank, the previous Malagasy government was in the process of promoting the sale of massive stocks and stockpiles of confiscated precious woods in order to reach a zero stocks goal, this being ostensibly to halt the illegal sourcing and trafficking of rosewood. We propose and analyse four potential options for stocks management by presenting a framework linking forest management with socio-economic objectives and comparative risks. Destruction (burning) of the known stocks would send out a strong conservation message and has the strongest chance of halting further sourcing, which happens mostly in protected areas and is therefore illegal. National trade is the option in which a precious timber sector would process the woods in stocks. This option is the most beneficial for development. Opening the stocks for exportation through international trade achieves the smallest number of objectives in relation to both forests and socio-economic indicators, but comes with the highest risks in terms of curbing further illegal logging. Banking represents a fourth option, which essentially postpones any decision related to stocks management by storing the stocks for extended periods. None of the four management options is able to ensure a sustainable solution that can resolve the issues surrounding the precious timber stocks. The approaches put forward are either just ‘more good’, or ‘less good’. If a country is seriously interested in conserving its biodiversity, any government has to ensure that no other sectorial changes will counteract, or potentially undermine, the efforts to protect the environment. Stocks management will be on agenda at the upcoming COP18 in Geneva, 17–28 August 2019.
From Interior to Interiority: Locating Key Historical Moments in the Relationship between Spaces and Individuals
Authors: Cruz Petit Bruno
Published: August 2019

We spend increasingly more time in architectural interiors, spaces that can give us quality of life and interesting scenarios for the growth of identity and interiority. However, both spatial interior and psychological interiority faces difficulties inherent to contemporary life. This text proposes a critical review of the literature on the socio-spatial archeology of the subject in order to see possible paths of realisation of interiority in the present. The document presents several stages in the sociocultural evolution of an interior space that needs to be described with different adjectives (spiritual, hedonistic, promiscuous) and groups the most relevant contributions of the literature according to this proposal.
Interiority: At the Threshold
Authors: Atmodiwirjo Paramita , Yatmo Yandi Andri
Published: August 2019

Being at the threshold offers an ambiguous spatial experience. The idea of threshold is relevant to the discourse of interiority, as it expands our understanding of the opposing condition of inside-outside, or interior-exterior, which have become the recurring themes in many discussions on interiority. This issue of Interiority attempts to address what actually occurs at the threshold – the occupation and the experience of the threshold. The contributors in this issue address the emergence of spatial ideas that define the new relationship between inside and outside, between interior and architecture.
Pressure-driven release of viral genome into a host nucleus is a mechanism leading to herpes infection
Authors: Brandariz-Nuñez Alberto , Liu Ting , Du Te , Evilevitch Alex
Published: August 2019

Many viruses previously have been shown to have pressurized genomes inside their viral protein shell, termed the capsid. This pressure results from the tight confinement of negatively charged viral nucleic acids inside the capsid. However, the relevance of capsid pressure to viral infection has not been demonstrated. In this work, we show that the internal DNA pressure of tens of atmospheres inside a herpesvirus capsid powers ejection of the viral genome into a host cell nucleus. To our knowledge, this provides the first demonstration of a pressure-dependent mechanism of viral genome penetration into a host nucleus, leading to infection of eukaryotic cells.
Identification of crucial genes based on expression profiles of hepatocellular carcinomas by bioinformatics analysis
Authors: Liu Ze-Kun , Zhang Ren-Yu , Yong Yu-Le , Zhang Zhi-Yun , Li Can , Chen Zhi-Nan , Bian Huijie
Published: August 2019

Hepatocellular carcinoma (HCC) is one of the most heterogeneous malignant cancers with no effective targets and treatments. However, the molecular pathogenesis of HCC remains largely uncertain. The aims of our study were to find crucial genes involved in HCC through multidimensional methods and revealed potential molecular mechanisms. Here, we reported the gene expression profile GSE121248 findings from 70 HCC and 37 adjacent normal tissues, all of which had chronic hepatitis B virus (HBV) infection, we were seeking to identify the dysregulated pathways, crucial genes and therapeutic targets implicated in HBV-associated HCC. We found 164 differentially expressed genes (DEGs) (92 downregulated genes and 72 upregulated genes). Gene ontology (GO) analysis of DEGs revealed significant functional enrichment of mitotic nuclear division, cell division, and the epoxygenase P450 pathway. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that the DEGs were mainly enriched in metabolism, cell cycle regulation and the p53 signaling pathway. The Mcode plugin was calculated to construct a module complex of DEGs, and the module was mainly enriched in cell cycle checkpoints, RHO GTPase effectors and cytochrome P450. Considering a weak contribution of each gene, gene set enrichment analysis (GSEA) was performed, revealing results consistent with those described above. Six crucial proteins were selected based on the degree of centrality, including NDC80, ESR1, ZWINT, NCAPG, ENO3 and CENPF. Real-time quantitative PCR analysis validated the six crucial genes had the same expression trend as predicted. Furthermore, the methylation data of The Cancer Genome Atlas (TCGA) with HCC showed that mRNA expression of crucial genes was negatively correlated with methylation levels of their promoter region. The overall survival reflected that high expression of NDC80, CENPF, ZWINT, and NCAPG significantly predicted poor prognosis, whereas ESR1 high expression exhibited a favorable prognosis. The identification of the crucial genes and pathways would contribute to the development of novel molecular targets and biomarker-driven treatments for HCC.
Genome-wide identification, characterization and expression analysis of the HD-Zip gene family in the stem development of the woody plant Prunus mume
Authors: Li Lulu , Zheng Tangchun , Zhuo Xiaokang , Li Suzhen , Qiu Like , Wang Jia , Cheng Tangren , Zhang Qixiang
Published: August 2019

The homeodomain-leucine zipper (HD-Zip) gene family, a group of plant-specific transcriptional factors (TFs), participates in regulating growth, development, and environmental responses. However, the characteristics and biological functions of HD-Zip genes in Prunus mume, which blooms in late winter or early spring, have not been reported. In this study, 32 HD-Zip genes, named PmHB1–PmHB32 based on their chromosomal positions, were identified in the genome of P. mume. These genes are distributed among seven chromosomes and are phylogenetically clustered into four major groups. Gene structure and motif composition were mostly conserved in each group. The Ka/Ks ratios showed that purifying selection has played a leading role in the long-term evolution of the genes, which maintained the function of this family. MicroRNA target site prediction indicated that the genes of the HD-Zip III subfamily may be regulated by miR165/166. Expression pattern analysis showed that the 32 genes were differentially expressed across five different tissues (leaf, flower bud, stem, fruit, and root) and at different stages of stem and leaf-bud development, suggesting that 10 of the genes may play important roles in stem development. Protein–protein interaction predictions showed that the subfamily III genes may regulate vascular development and shoot apical meristem (SAM) maintenance. Promoter analysis showed that the HD-Zip III genes might be involved in responses to light, hormones, and abiotic stressors and stem development. Taken together, our results provide an overview of the HD-Zip family in P. mume and lay the foundation for the molecular breeding of woody ornamental plants.
Bathymetric Survey and Topography Changes Investigation of Part of Badagry Creek and Yewa River, Lagos State, Southwest Nigeria
Authors: Temitope Badejo, Olusegun , Kehinde Adewuyi, Gbola
Published: August 2019

Bathymetry survey of Part of Badagry Creek and Yewa River was conducted with the aim of investigating the topography changes in depth between two epoch dataset by calculating the volume of sediment and dredged material between the two periods. Depth sounding at 100m interval, data grid of 100 m interval, constant vessel speed of 2.2 m/secs (8Km/hr) for data capture, data storage at interval of 30 Secs was ensured at both the creek and the river. Seabed topography changes of Part of Badagry Creek and Yewa River was investigated. The two dataset investigated was the data acquired in September 2008 and November 2015. Data acquisition was done using digital echo sounder SDE28, Handheld Real time Kinematic (RTK) Global Positioning System (GPS) in acquiring the spatial coordinates (x, y) and water depth (z). Six (6) wrecks (Shipping Boat) were determined along both the creek and the river. The initial processing was carried out with the use of HYPACK 2008 software for data sorting. ArcGIS 10.2.1 was used for data analysis as well as graphics design. The processed depths were presented in form of tables, map/plan and charts. The result showed that In 2008, the depth observed ranges from (-0.5 to 10.4) m while in 2015, the depth observed ranges from (-0.32 to 10.85) m which implies that some area have been cut.  Also, the results of the volume of deposited sediments and dredged material are computed as 10.55 x 106 m3 and 7.24 x 106 m3. It showed from the result that volume of accreted sediment is greater than volume of the material dredged. Increase in volume of sediment deposited could be as a result of the adjoining river Yewa flowing into the larger river (tributaries) of the Badagry Creek. Therefore, further studies need to carry out in order to know the source of accreted mass through integrated coastal management plan.
Assessment of Effective Operational Parameters on Removal of Amoxicillin from Synthetic Wastewater Using Electrocoagulation Process
Authors: Balarak Davoud , Chandrika Kethineni , Attaolahi Marzieh
Published: August 2019

In this study, efficiency of electrocoagulation (EC) process with aluminum electrodes for treatment of Amoxicillin (AMO) from synthetic solution has been studied and concluded. This experiment was conducted in a batch system with a volume of 1 L that had been equipped with four aluminum electrodes. The effect of operating parameters, such as voltage, time of reaction, initial AMO concentration, KCl concentration and pH on the AMO removal efficiency was investigated. In optimum condition (pH 7, voltage 60 V, electrolysis time 75 min, KCl concentration 3 g/L), electrocoagulation method was able to remove 98.8% of AMO antibiotics from synthetic solution.  In addition, it is found that an increase in the applied voltage the speed of the treatment significantly. However, simultaneous increase of electrode and energy consumption was observed. The method was found to be highly efficient and relatively fast compared to conventional existing techniques and also, it can be concluded that the electrocoagulation process has the potential to be utilized for the cost-effective removal of AMO from water and wastewater.