bluuebunny/crossref_metadata_2025 huggingface dataset:
The Development of Social Capital during the Process of Starting an Agritourism Business
Authors: Khazami Nesrine , Lakner Zoltan
Published: February 2022

The role of social capital in the early phases of development of a family business is well documented, but the dynamism of the entrepreneur’s social capital in the agritourism business remains a relatively lesser-studied area. The current research, on an inductive, exploratory, and qualitative basis, aims to uncover the place and role of social capital in the establishment of agritourism enterprise, from concept formation to stabilization. The results of the study highlight the importance of governmental help in finance and networking for launching an enterprise, especially in remote areas where these additional activities are relatively lesser-known. The role of a network is relatively weak in the risk analysis of the business. This fact enhances the vulnerability of enterprises.
In Silico Approach Gives Insights into Ig-like Fold Containing Proteins in Vibrio parahaemolyticus: A Focus on the Fibrillar Adhesins
Authors: Wang Dan , Wang Haoran
Published: February 2022

Immunoglobulin-like (Ig-like) fold domains are abundant on the surface of bacteria, where they are required for cell-to-cell recognition, adhesion, biofilm formation, and conjugative transfer. Fibrillar adhesins are proteins with Ig-like fold(s) that have filamentous structures at the cell surface, being thinner and more flexible than pili. While the roles of fibrillar adhesins have been proposed in bacteria overall, their characterization in Vibrio parahaemolyticus has not been established and, therefore, understanding about fibrillar adhesins remain limited in V. parahaemolyticus. This in silico analysis can aid in the systematic identification of Ig-like-folded and fibrillar adhesin-like proteins in V. parahaemolyticus, opening new avenues for disease prevention by interfering in microbial interaction between V. parahaemolyticus and the host.
Conserved Residues Adjacent to ß-Barrel and Loop Intersection among Enterovirus VP1 Affect Viral Replication: Potential Target for Anti-Enteroviral Development
Authors: Huang Ya-Ling , Huang Sheng-Wen , Shen Chun-Yu , Cheng Dayna , Wang Jen-Ren
Published: February 2022

Enterovirus genus has over one hundred genotypes and could cause several kinds of severe animal and human diseases. Understanding the role of conserved residues in the VP1 capsid protein among the enterovirus genus may lead to anti-enteroviral drug development. The highly conserved residues were found to be located at the loop and ß-barrel intersections. To elucidate the role of these VP1 residues among the enterovirus genus, alanine substitution reverse genetics (rg) variants were generated, and virus properties were investigated for their impact. Six highly conserved residues were identified as located near the inside of the canyon, and four of them were close to the ß-barrel and loop intersection. The variants rgVP1-R86A, rgVP1-P193A, rgVP1-G231A, and rgVP1-K256A were unable to be obtained, which may be due to disruption in the virus replication process. In contrast, rgVP1-E134A and rgVP1-P157A replicated well and rgVP1-P157A showed smaller plaque size, lower viral growth kinetics, and thermal instability at 39.5°C when compared to the rg wild type virus. These findings showed that the conserved residues located at the ß-barrel and loop junction play roles in modulating viral replication, which may provide a pivotal role for pan-enteroviral inhibitor candidate.
The Impact of Dietary Berberine Supplementation during the Transition Period on Blood Parameters, Antioxidant Indicators and Fatty Acids Profile in Colostrum and Milk of Dairy Goats
Authors: Ghavipanje Navid , Fathi Nasri Mohammad Hasan , Farhangfar Seyyed Homayoun , Ghiasi Seyyed Ehsan , Vargas-Bello-Pérez Einar
Published: February 2022

The objective of this study was to investigate the effect of berberine (BBR) supplementation on productivity, antioxidant markers, and the fatty acid (FA) profile in the colostrum and milk of goats. Twenty-four primiparous Saanen goats were supplemented with 0, 1, 2, and 4 g/d (per goat) of BBR in control (CON), BBR1, BBR2, and BBR4 groups (n = 6 per group), respectively, from 21 days before expected kidding to 21 days after parturition. Blood sampling was carried out at −21, −14, −7, 0, 7, 14, and 21 d relative to delivery. Colostrum was collected within the first and second milking (d 1 of lactation), and milk was harvested weekly after kidding. Both BBR2 and BBR4 increased dry matter intake (DMI) (p ≤ 0.05) and energy balance (EB) as well as colostrum and milk production. Both BBR2 and BBR4 decreased (p ≤ 0.05) plasma levels of cholesterol, haptoglobin, and ceruloplasmin, while elevating the plasma albumin and paraoxonase (p ≤ 0.05), which may indicate that BBR mitigates inflammation during the transition period. BBR reduced (p ≤ 0.05) malondialdehyde (MDA) and increased (p ≤ 0.05) total antioxidant capacity (TAC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in blood, colostrum, and milk. Concentrations of de novo fatty acid in colostrum and milk were increased (p ≤ 0.05) with both BBR2 and BBR4. Free fatty acid (FFA) concentration in colostrum and milk fat were lower (p ≤ 0.05) in BBR2 and BBR4 compared to CON. The concentration of saturated fatty acids (SFAs) in colostrum and milk fat increased (p ≤ 0.05) with BBR2 and BBR4, while unsaturated fatty acids (USFAs) decreased (p ≤ 0.05) in milk. In summary, supplementation with at least 2 g/d BBR may enhance the EB and antioxidant status of dairy goats.
Chemometric Evaluation of WWTPs’ Wastewaters and Receiving Surface Waters in Bulgaria
Authors: Mihaylova Veronika , Yotova Galina , Kudłak Błażej , Venelinov Tony , Tsakovski Stefan
Published: February 2022

Wastewater treatment plant (WWTP) installations are designed and operated to reduce the quantity of pollutants emitted to surface waters receiving treated wastewaters. In this work, we used classical instrumental studies (to determine chemicals and parameters under obligations put with Directive 91/271/EEC), ecotoxicological tools (Sinapis alba root growth inhibition (SA-RG) and Heterocypris incongruens mortality (MORT) and growth inhibition (GRINH)) and multivariate statistical analysis to gain information on feature profiles of WWTPs’ effluents and the possible burden of surface water bodies receiving treated wastewaters in eleven locations of Bulgaria. Initial screening of results has shown that only phosphorus content exceeds the admissible level in 5 out 11 WWTP effluents, while As, Cr, Cu, Mn, and Zn show exceedance at several locations. The multivariate statistical analysis reveals the discriminating water quality parameters and outlines the ability of Heterocypris incongruens to evaluate the ecotoxicological potential of different groups of waters.
Soil Conservation Measures on Degraded Land in the Hilly Region of Eastern Romania: A Case Study from Puriceni-Bahnari Catchment
Authors: Niacsu Lilian , Bucur Daniel , Ionita Ion , Codru Ionut-Costel
Published: February 2022

Land degradation through erosion processes is probably the most restrictive issue regarding the sustainable agricultural use of land resources in contemporary Romania. The socio-economic changes that occurred in Romanian society after 1990 resulted in a sharp decline in the implementation of conservation practices along with an increase in intensity of land degradation. Consequently, the present paper firstly aims to analyse the actual spread and intensity of land degradation in the Puriceni-Bahnari catchment, representative area in terms soil erosion within Moldavian Plateau of Eastern Romania. Secondly, the achievement of a dedicated project at the level of the entire basin regarding the implementation of land conservation practices is the most suitable solution for the sustainable agricultural use of this fragile natural resource. The results prove the severe degradation state of the agricultural land, with a mean value of annual soil loss of 15.46 t·ha−1·yr−1 (13,500 t·yr−1). Furthermore, 460 ha of agricultural lands (72.7% of total) falls within the category that exceeds the limit of admissible erosion of 7 t·ha−1·yr−1. As a solution to the existing land use pattern, we designed a map of proposed conservation measures and works on agricultural land for the whole catchment that can be relatively easily implemented and conserve soil and water. The main issues of the proposed land use pattern are: (1) the entire cropland must be reduced and changed to a strip-cropping system; (2) the quality of the pastures should be improved; (3) the forested area must be substantially extended, especially on account of unproductive land, and (4) the agricultural road network must be halved and entirely reshaped. In conclusion, the large-scale implementation of conservation practices on degraded agricultural land is the only rational solution for sustainable development of poor local communities in the hilly areas from eastern Romania.
Agricultural Pollution and Waterways on the Island of Ireland: Towards Effective Policy Solutions
Authors: Attorp Adrienne
Published: February 2022

In the UK, Ireland and Europe generally, much attention has been devoted to understanding how the agri-food sector has leveraged disproportionate focus and support through its influence in the policymaking area. What has received less focus is how power is distributed within the agriculture sector, i.e., why/how some agricultural industries are more ‘successful’ or receive more focus than others, and what this means for policy. Researchers typically treat ‘farmers’ as a monolith, for example, focusing on the power of the ‘farming lobby’ versus that of other interest groups such as environmentalists. This tells us only part of the picture; power distributions within the agriculture industry itself also have implications for policy. Using empirical qualitative research (interviews, focus groups) conducted on the island of Ireland, this paper shows how some agri-food sectors (e.g., dairy) hold more power than others meaning they can resist important regulation such as water pollution initiatives. This renders such regulation ineffective. Meanwhile, other sectors (e.g., beef and sheep) are left out of the conversation, which compromises potential policy solutions. It argues that for future policies to adequately address the challenge of agriculture-related environmental degradation and support the resilience of the ecosystems upon which food production depends, agri-food system governance must become more equitable and nuanced, allowing for tangible consideration of the challenges that different agriculture sectors face.
Philosophical aspect of culturological study of cinema
Authors:   State Institute of Art Studies of the Ministry of Culture of the Russian Federation, Khrenov N.A. , Khrenov A.N. ,   Research Sector of the Academy of Media Industry
Published: February 2022

This article focuses on the issue of developing a separate trend in cinema studies — the philosophy of cinema. The experience of the auteur cinema, related to direct visualization of the philosophical underones in films, and its relation to such philosophical movements as the philosophy of life, existentialism, postmodernism, etc, creates a neccessity to develop such a trend. The article underlines some specific problems of cinema that require philosophical research. This is, first, the problem of the cinematic experience that the authors put under scrutiny discussing the collective monograph “Cinematic experience. History — theory — practice”, produced by the philosophers from St. Petersburg. Secondly, it is the specifics of time in cinema, for the discussion of which the authors address the concepts of A. Bergson, M. Heidegger and G. Deleuze. Thirdly, the article raises the question of corporeality, this topical philosophical problem today — here it is discussed in relation to cinema. The intrusion of technology into the communication of cinema with the mass audience noticeably destroys the existing connection between the rational and the sensual, the spiritual and the corporeal principles in thinking and in the perception of art.
Semantics of metamorphosis in the motive of magical flight
Authors:   V.I. Abayev North Ossetian Institute of Humanitarian and Social Research — Branch of the Federal State Budgetary Institution of Science of the Federal Scientific Center “Vladikavkaz Scientific Center of the Russian Academy of Sciences”, Takazov F.M.
Published: February 2022

The article considers a typological series of plots with a motive for magical flight. The object of the analysis was metamorphoses of objects that the fugitive threw in front of the pursuer. The motive for magical flight is widespread in folklore of the peoples of the Caucasus, Europe, Asia, Africa and America. The material for the research was Caucasian (Abkhaz, Adyghe, Ingush, Ossetian, Balkarian), Slavic (Russian, Ukrainian, Polish, Bulgarian) and European (Spanish, Swedish) tales. The author drew attention to the initiating nature of the subjects of fairy tales considered. The semantics of metamorphosis of thrown objects were determined. The character's throwing of three objects symbolizing the upper, middle and lower worlds reproduces the creation of three worlds. The pursuer, as a rule, stops or dies when trying to overcome the water barrier that symbolizes the lower world. With a victory over the lower world, the hero completes the initiation path and goes on to a new status, the manifestation of which is the marriage of the character.
EFFECT OF TPS STRATEGY ON STUDENTS’ LISTENING SKILLS USING POLAROID SONG AT PERGURUAN BUDDHIS BODHICITTA JUNIOR HIGH SCHOOL
Authors: Hongko HONGKO
Published: February 2022

The effect of TPS Strategy particularly in listening is very important in the study of English language because listening skills are often considered critical in building communication. It provides a new technique which can be applied in listening.

This research, however, is to find out whether TPS Strategy significantly affects students’ listening skills at PERGURUAN BUDDHIS BODHICITTA JUNIOR HIGH SCHOOL. The result shows that both pre-test and post-test were accumulated in to two different class groups namely, experimental (using TPS Strategy) and controlled group (not using TPS Strategy). The experimental group in pre-test has resulted 58.5 in average while the post-test has resulted 75.5 in average. On the other hand, the controlled group in the pre-test has resulted 52.8 in average  whereas the post-test has resulted 62.2 in average. From the result, it was clear that the use of TPS Strategy (experimental group) gave significant effect on students listening skills.

Key Words: Effect, TPS Strategy, Listening Skills
Analysis of Code Mixing Used by Teacher
Authors: Manalu Agustinus
Published: February 2022

ABSTRACT

This thesis was aimed to find the type of code mixing used by teacher during classroom interaction. The study used descriptive qualitative method. Each sentence from the teacher and students conversation was identified to determine its code mixing type according to Hoffman’s theory (1991). The data of the study is utterances which code mixing is included in it. The technique of the data collections used is documentary technique. It is found that there were three types of code mixing used during the class according to Hoffman theory namely : (1) intra-sentential, (2) intra-lexical, (3) involving change of pronunciation. From those types, intra-sentential was most frequently used by the teacher during the process of teaching and learning. The teacher`s reasons for applying code mixing were to overcome the communication barriers that occur between the teacher and the students to help the students understand and memorize the material more accessible. The result of the interview also showed that the students had a good perception of the implementation of code mixing used by the teacher in the classroom.

Keyword : code mixing, intra-sentential, classroom interaction, teacher
AN ANALYSIS STUDENT’S ABILITY IN WRITING PROCEDURE TEXT BY USING PICTURE SERIES AT SMP TELADAN MEDAN
Authors: LTP ELTP , Tarigan Sri Ninta , Ginting Lisnawaty br
Published: February 2022

Abstract

 

This research purposed to know the students‟ ability in writing procedure text . The location of this research was in SMP Teladan Medan.The time that was spend in this research was two days. This research was applied by qualitative content analysis. The subject of the research was the students at grade EIGHTH GRADE OF SMP TELADAN MEDAN . Students consist of 26 students. The instruments that used in this research was a test of writing procedure text, interview. The test was asking the students to write the procedure text by using picture series  well. Based on the result of the research, the students‟ ability in writing procedure text was low. From this research, there are two instruments in examining their ability including vocabulary,style,mechanism,grammar. It is hoped that by the finding of these trouble, there will be future research on this subject so that there will be some method or strategy that enable to overcome these troubles.

engl

Key words: ability, writing, procedure text, picture series
MORAL VALUE AND CHARACTER-BUILDING EDUCATION IN FOLKLORE: SI GALE GALE
Authors: Jannah Nur , Br Surbakti Sri Karolina , Tarigan Aryani Monita , Gulo Achida Niasti Veronica
Published: February 2022

In character building education and moral values there are significant things that are writtenin the meaning of folklore as a characteristic of a culture. The aim of this study is to describefolklore as a way to build character education and increasing moral values into an education.SIGALE-GALE PEOPLE'S STORIES FROM TAPANULI UTARA as source of data in thisresearch. After analyzing and recording important points in the story through a qualitativedescriptive method, several things can be obtained that contain character building educationand moral values in the SIGALE-GALE story: individual, social, and religious moral values.Which can be applied in attitudes and behaviors in character building education.This research uses the technique of content analysis, which is a research analysis that revealsthe ideas of the author or creator, both manifestly and latently. There for, it can be concludedthat the SIGALE-GALE folklore apart from being an education to build character and moralvalues can also be a means of getting to know ancestors and their stories for futuregenerations.Keywords: character buiding education, moral value, folklore, SIGALE-GALE.
DEFINING FRIENDSHIP THROUGH THE FILM ALADDIN (2019)
Authors: Sinabutar2 Dwita Oktaviani , Tampubolon Three Debora E. , Yunus Lesly , Siregar Mariana , Rudy Rudy
Published: February 2022

Abstract

 

As one of the important things in human life, friendship is an essential discussion because it is experienced by almost all people. Moreover, the portrait of friendship has been frequently shown in films. Therefore, this study aims to identify how friendship is depicted in the film Aladdin (2019) and to analyze the significance of friendship for people. It is expected that this study can contribute in the form of theory development in social and cultural studies and help people understand the value of friendship. The picture of friendship that appears in the film in the form of dialogs was used as the main data to be analyzed in this study. By applying representation theory as a semiotic approach, film dialogs were treated as symbols that could be interpreted. The result of analysis reveals that the representation of friendship in the Aladdin can be seen through the three main concepts – the sense of care, mutuality and solidarity which are considered significant in friendship. Furthermore, the result also reveals that everyone can interpret friendship based on their experience. This also affects the purpose of friendship.

 

Keywords: friendship, representation of friendship, care, mutuality, solidarity
ANALISIS TINDAK TUTUR DIREKTIF ANAK USIA 4-5 TAHUN PADA BAHASA DI TK HARAPAN BARU MEDAN
Authors: Girsang Jans Linson , Purba Christin Agustina
Published: February 2022

Penilitian   Mendeskripsikan bentuk tindak tutur di rektif yang digunakan anak 4-5 Tahun TAMAN Kanak kanak ( TK Harapan Baru Medan ) untuk mengetahui jenis tindak tutur direksi yang  sering di gunakan  anak usia 4-5 tahun  Di Perguruan TK Harapan Baru 3 Medan. Penelitian ini menggunakan metode dengan desain penelitian Kualitatif  dimana desaain penelitian ini  menggunakan teknik pengmpulan data denga menggunakan metode observasi langsung dan wawancara di lapangan. Dengan populasi dalam penelitian ini adalah peser ta  didik  berusia 4-5  Tahun  bentuk tindak tutur meminta secara langsung dan tidak langsung. Sedangkan bentuk mengizinkan secara lansung dan tidak langsung dan mengusulkan secara langsung  Selain itu faktor - faktor intensitas munculnya ketiga tuturan tersebut lebih  sering di bandingkan tindak tutur mengusulkan dan mengigizinkan dalam kehidupan. Hasil dari penelitian ini

 

Kata kunci : tindaktutur,  bahasa anak
CHARACTER VALUE EXPLORE IN LASKAR PELANGI AS A STRENGTHENING OF STUDENTS’ CHARACTER BUILDING
Authors: Rumapea Resti , Tambunan Berlian , Pardosi Winda Yuliani
Published: February 2022

Abstract

 

This study aims to determine the character values of students, examine whether the good characters in the Laskar Pelangi film can be applied in teaching and learning life, and apply moral values that can be used with qualitative descriptive methods. And reading which was used in collecting data, it was found that Laskar Pelangi is a film that teaches very good norms and moral values that can be expected for educational activities, especially teaching and learning. We hope that this research can make readers more motivated and make this research one of the teaching resources that can be applied in student character education.

Keywords: Character building, Film, Character value
Case of Surgical Treatment of Ectopic Pupil because of Traumatic Injury of Cornea with Prolapse of Iris
Authors: Каплич Л.Л.
Published: February 2022

Цель. Продемонстрировать случай хирургического лечения эктопии зрачка в исходе проникающего ранения. Материалы. Пациент Л., 34 года, получил травму в детстве, в результате которой произошла эктопия зрачка, что привело к снижению зрения и косметическому дефекту. Результаты. Была проведена реконструкция зрачка. Спустя 2 месяца проведена лазерная дисцизия задней капсулы хрусталика. Устранили косметический дефект, повысились зрительные функции.

Purpose. The purpose of the work is demonstration of the case of surgical treatment ectopia of the pupil in the outcome of a penetrating injury. Materials. Patient L., 34 years old, suffered an injury in childhood, the outcome of which occurred ectopia of the pupil, which led to a decrease in vision and a cosmetic defect. Results. The pupil was reconstructed. After 2 months, a laser discission of the posterior capsule of the lens. Dropped out cosmetic defect, increased visual function.
Negative Symptoms and Problem Alcohol Drinking in People with Schizophrenia
Authors: Хмара Н.В. , Скугаревский О.А.
Published: February 2022

Работа посвящена не достигающему критериев зависимого поведения потреблению алкоголя, влияющему на проявление негативных симптомов у лиц с шизофренией. Использованы психометрические инструменты оценки: шкала-скрининг ASSIST - для выявления употребления алкоголя и шкала PANSS - для формализованной оценки степени выраженности негативных симптомов. В исследовании приняли участие 123 пациента, проходивших стационарное лечение в Гомельской областной клинической психиатрической больнице с диагнозами «шизофрения» и «острые полиморфные психотические расстройства шизофренического спектра». В ходе исследования получены следующие данные: различный уровень выраженности потребления алкоголя (шкала ASSIST) находится в сопряженных отношениях с уровнем социальной дезадаптации, негативными симптомами. Группа с «низким риском» имела менее выраженные негативные симптомы за счет показателей: «уплощение аффекта», «эмоциональная отстраненность», «недостаточный раппорт», «стереотипность мышления». Группа с проблемным потреблением алкоголя в сравнении с контрольной группой не имела статистически значимых различий.

This article is devoted to those who do not reach the criteria of the dependent behavior of alcoholconsumption for manifestation of negative symptoms in persons with schizophrenia. The followingpsychometric assessment tools were used: the ASSIST screening scale for detecting alcohol consumptionand the PANSS scale for formalized assessment of the severity of negative symptoms. The study involved123 patients undergoing inpatient treatment at the Gomel Regional Clinical Psychiatric Hospitalwith diagnoses of schizophrenia and acute polymorphic psychotic disorders of the schizophrenicspectrum. The following data were obtained: different levels of alcohol consumption (ASSIST scale)are in connection with the level of social maladjustment, negative symptoms. The group with “lowrisk” had less pronounced negative symptoms due to the following indicators: “flattening of affect”,“emotional detachment”, “insufficient report”, “stereotyped thinking”. The group with problematic alcoholconsumption in comparison with the control group did not have statistically significant differences.
New Opportunities in Pharmacotherapy of Anxiety Disorders
Authors: Ассанович М.А.
Published: February 2022

Тревожные расстройства относятся к распространенным психическим расстройствам. Генерализованное тревожное расстройство (ГТР) и социофобия оказывают выраженное негативное влияние на повседневное функционирование, существенно снижают качество жизни, требуют длительной терапии. Препаратами первого выбора в терапии ГТР и социофобии являются антидепрессанты СИОЗС и СИОЗСН, при необходимости бензодиазепиновые транквилизаторы. Однако эффективность антидепрессантов не превышает 75%, часто возникают побочные эффекты, бензодиазепины не подходят для длительного приема вследствие нежелательных эффектов. Новые возможности в фармакотерапии тревожных расстройств связаны сназначением новых препаратов. Перспективным препаратом является прегабалин. Анксиолитический механизм действия прегабалина основан на блокировании потенциал-зависимых кальциевых каналов, что приводит к ингибированию секреции тревожных нейротрансмиттеров. Прегабалин не действует на другие рецепторы, имеет линейную фармакокинетику, не имеет значимых лекарственных взаимодействий, хорошо переносится пациентами, позволяет регулировать дозировки в широком диапазоне, полностью подходит как для длительного приема, так и для купирования ситуационной тревоги. Начальная доза составляет 150 мг/сут. Рекомендуемая эффективная дозировка: 300-600 мг/сут 2-3 раза в день. Терапевтический эффект проявляется на первой неделе приема. Прегабалин может использоваться совместно с антидепрессантами СИОЗС и СИОЗСН либо в виде монотерапии как препарат первого выбора.

Anxiety disorders are common mental disorders. Generalized anxiety disorder (GAD) and socialphobia have a pronounced negative effect on daily functioning, significantly reduce quality oflife, and require long-term therapy. Medicines of the first choice in treatment of GAD and socialphobia are antidepressants SSRIs and SNRIs, if necessary, benzodiazepine tranquilizers. However,effectiveness of antidepressants does not exceed 75%, side effects often occur, and benzodiazepinesare not suitable for long-term use due to unwanted effects. New opportunities in pharmacotherapyof anxiety disorders are associated with prescription of new drugs. Pregabalin is a promising drug.Anxiolytic mechanism of action of pregabalin is based on blocking the voltage-gated calciumchannels, which leads to inhibition of secretion of anxious neurotransmitters. Pregabalin does notaffect other receptors, has linear pharmacokinetics, does not have significant drug interactions, iswell tolerated by patients, allows dosage adjustment in a wide range, and it is fully suitable for bothlong-term use and relief of situational anxiety. The initial dose is 150 mg/day. The recommendedeffective dosage is 300–600 mg/day 2–3 times a day. Therapeutic effect is manifested during thefirst week of administration. Pregabalin can be used in conjunction with antidepressants SSRIs andSNRIs or as monotherapy (the first choice drug).
Cardiovascular Manifestations and Complications in Marfan, Loyes - Dietz, Ehlers - Danlos Syndromes
Authors: Трисветова Е.Л.
Published: February 2022

Диагностика наследственных нарушений соединительной ткани основывается на оценке фенотипа, клинических признаках и результатах молекулярно-генетического исследования. Для синдромов Марфана, Лойеса - Дитца и Элерса - Данло характерными являются поражения сердечно-сосудистой системы, влияющие на качество и прогноз жизни. Один из основных клинических признаков при синдроме Марфана - расширение/аневризма грудной аорты, который постепенно прогрессирует и без хирургического лечения приводит к осложнениям в виде разрыва или диссекции сосуда. Поражение артериальных сосудов и аорты при синдроме Лойеса - Дитца протекает агрессивнее по сравнению с синдромом Марфана, и незначительное расширение или патологическая извитость являются показанием для раннего оперативного лечения, поскольку быстро приводят к разрыву сосуда и серьезным осложнениям. При синдроме Элерса - Данло, преимущественно при сосудистом типе, появляются аневризмы и диссекция артериальных сосудов среднего калибра и/или расширение/аневризма грудной аорты, оперативное лечение которых без учета характера изменения соединительной ткани часто неэффективно. Своевременное распознавание синдромов, инструментальная диагностика сердечно-сосудистых проявлений позволят определить оптимальную тактику лечения и предупредить осложнения.

Diagnosis of hereditary disorders of connective tissue is based on the assessment of the phenotype, clinical signs, and results of molecular genetic research. For the syndrome of Marfan, Loyes - Dietz, and Ehlers - Danlos, the lesions of the cardiovascular system are typical, affecting the quality and prognosis of life. One of the main clinical signs in Marfan syndrome is the expansion/aneurysm of the thoracic aorta, which gradually progresses and without surgical treatment leads to complications in the form of rupture or dissection of the vessel. The lesion of the arterial vessels and aorta in Loyes-Dietz syndrome is more aggressive than in Marfan syndrome, and slight dilatation or pathological tortuosity is an indication for early surgical treatment, because it quickly leads to rupture of the vessel and serious complications. In Ehlers-Danlos syndrome, mainly in the vascular type, the aneurysms and dissection of medium-sized arterial vessels and/or expansion/aneurysm of the thoracic aorta appear, the surgical treatment of which without taking into account the nature of changes in the connective tissue is often ineffective. Timely recognition of syndromes, instrumental diagnostics of cardiovascular manifestations will help to determine the optimal treatment tactics and prevent complications.
Blood Infections Caused by Enterobacteria in Patients with Acute Leukemia: Current State of the Problem and Results of a Clinical Study
Authors: Большова Н.А. , Стома И.О. , Искров И.А.
Published: February 2022

Одним из важных механизмов устойчивости энтеробактерий является продукция β-лактамаз расширенного спектра (БЛРС), цефалоспориназ AmpC и карбапенемаз. Распространенность этих β-лактамаз увеличивается во всем мире, включая европейские страны. Рост количества резистентных микроорганизмов и связанное с ними влияние на смертность во всем мире составляет острую необходимость как в дополнительных терапевтических вариантах, так и в усилении контроля над применением антимикробных препаратов. Клиническую эффективность в отношении этих энтеробактерий могут сохранять ингибитор-защищенные β-лактамы, однако наиболее надежным режимом антибактериальной терапии считают применение карбапенемов, что способствовало их значительному увеличению потребления во всем мире и может быть частично связано с последующим распространением устойчивости к карбапенемам. Одним из способов преодоления резистентности, обусловленной продукцией β-лактамаз, является использование комбинаций β-лактамных антибиотиков с ингибиторами β-лактамаз. Появление новых ингибиторов β-лактамаз, в частности авибактама, активного против нескольких групп ферментов, не чувствительных к действию «классических» ингибиторов, представляет собой существенное достижение антимикробной терапии. Целью исследования явились определение возбудителей инфекций кровотока у пациентов с острыми лейкозами и оценка эффективности стартовых режимов антибактериальной терапии, используемых в условиях гематологического стационара.

One of the important mechanisms of enterobacterial resistance is the production of extended spectrum β-lactamases (ESBL), AmpC cephalosporinases, and carbapenemases. The prevalence of these β-lactamases is increasing throughout the world, including European countries. The increase of the number of resistant microorganisms and the associated impact on mortality worldwide is an urgent need for both additional therapeutic options and increased control over the use of antimicrobial drugs. Inhibitor-protected β-lactams may retain clinical efficacy against these enterobacteria, but carbapenems are believed to be the most reliable antibiotic regimen, which has contributed to a significant increase of carbapenem consumption worldwide and may be partly related to the subsequent spread of carbapenem resistance. One of the ways to overcome the resistance caused by the production of β-lactamases is the use of combinations of β-lactam antibiotics with β-lactamase inhibitors. The emergence of new inhibitors of β-lactamases, in particular avibactam, which is active against several groups of enzymes that are not sensitive to the action of“classical”inhibitors, represents a significant achievement in antimicrobial therapy. The aim of the study was to determine the causative agents of bloodstream infections in patients with acute leukemia and to evaluate the effectiveness of antibiotic therapy regimens used in a hematological hospital.
Diagnostic Significance of Ultrasonography of the Knee Joints in Patients with Hemophilia
Authors: Аверьянов Е.В. , Семеняка В.И. , Асса А.В.
Published: February 2022

Гемофилическая артропатия возникает вследствие частых кровоизлияний в синовиальные суставы и сопровождается развитием синовита. Установление активности синовита имеет ключевое значение для определения интенсивности и тактики лечения. В данной работе рассматривается диагностическая ценность ультрасонографии для визуализации структур сустава и определения активности синовита. Было обследовано 106 пациентов с тяжелой формой гемофилии и 25 практически здоровых лиц. У пациентов с гемофилией была диагностирована гемофилическая артропатия разных стадий. Высокочувствительное сонографическое сканирование КС выполняли в режиме реального времени с помощью аппарата «Aloka 4000» (Япония), используя линейный датчик с частотой 7,5 МГц. Установлено, что ультрасонография позволяет выявлять ранние признаки хронического прогрессирующего синовита разной активности, оценить интенсивность накопления выпота и степень гипертрофии синовиальной оболочки, определить уровень дегенерации суставного хряща. Показано, что ультрасонография может быть использована как один из методов для дифференциальной диагностики активно прогрессирующего и медленно прогрессирующего синовита у пациентов с гемофилией.

Hemophilic arthropathy occurs as a result of frequent hemorrhages in the synovial joints and is accompanied by the development of synovitis. Establishing the activity of synovitis is of key importance for determining the intensity and tactics of treatment. This article discusses the diagnostic value of ultrasonography for visualizing joint structures and determining the activity of synovitis. We examined 106 patients with severe hemophilia and 25 apparently healthy individuals. Patients with hemophilia were diagnosed with hemophilic arthropathy of various stages. Highly sensitive sonographic scanning of the knee joints was performed in real time using an Aloka-4000 apparatus (Japan) and a linear transducer with a frequency of 7.5 MHz. It was found that ultrasonography allows detecting early signs of chronic progressive synovitis of different activity, assessing the intensity of effusion accumulation and the degree of synovial hypertrophy, and determining the level of degeneration of the articular cartilage. It has been shown that ultrasonography can be used as one of the methods for the differential diagnosis of active and slowly progressing synovitis in patients with hemophilia.
Android service to interface mosquitto messaging broker (MQTT)
Authors: Gallardo Paredes Cristian Mauricio , Rodríguez Fiallos Patricia del Rocío , Galora Silva Francisco Javier
Published: February 2022

Real-time messages are used at a high level by different computer applications, there are different servers, protocols, etc. that can be used and are available on the Internet, however, these are created in such a way that the consumption of computational resources is very high and would only be optimal if we use a server with great features. This research work aims to develop a service on Android service to interface mosquitto messaging broker (MQTT) and provide a suitable mechanism to receive requests from an Android application at the same time also notify that some data has arrived, data are stored in the SQLite manager, which uses few computational resources and is suitable for small applications, which are testing protocols and messaging servers. The experimental results show that the service meets the initial objectives of the work, allowing to create of a messaging system based on publishers and subscribers for the Android platform.
Reportaje a Ánfora
Authors: Cúneo Claudio
Published: February 2022

"Participantes: Ignacio Blaconá (IB), Leo Villarruel (LV), y Entrevistadoras (E) Gisela Santanocito, Lorena Figueras..."
SISTEM INFORMASI LAYANAN ADMINISTRASI KEPENDUDUKAN PADA DESA MALIAYA BERBASIS WEB
Authors: Padli Padli , Sarjan Muhammad , Qashlim Akhmad
Published: February 2022

Pengembangan Pencatatan dan pengolahan data penduduk merupakan tanggung jawab pemerintah desa, dimana pelaksanaan nya di awali dari kelurahan atau desa selaku awal pendaftaran penduduk. Pelayanan tersebut perlu dilakukan dengan cepat dan tepat untuk mendapatkan suatu informasi. Dalam meningkatkan pendataan penduduk dan laporannya kepada kantor kecamatan, maka diperlukannya suatu perancangan sistem pada pendataan penduduk. Desa Maliaya mempunyai jumlah penduduk sekitar 2000 jiwa, selama ini sistemnya masih manual menggunakan Microsoft excel. Hal ini menimbulkan beberapa kendala yang cukup merepotkan, terutama pada ketidak validan dan ketidak cocokan data. Sering pula terjadi kendala pada saat pencarian informasi tentang penduduk baru, Pengaduan masyarakat terkait terhadap Pemda adalah mengenai penundaan berlarut-larut. Terutama berkaitan pengurusan administrasi seperti KTP (Kartu Tanda Penduduk), akta kelahiran, dan surat tanah, dan perizinan maupun penduduk yang pindah dari desa tersebut. penelitian ini adalah metode kuantitatif. Penelitian kuantitatif pada dasarnya  merupakan suatu pengamatan yang melibatkan suatu ciri tertentu, berupa teknik observasi, wawancaara mendalam. Hasil penelitian ini adalah sebuah sistem informasi layanan kependuduk pada desa maliaya berbasis website serta menggunaan bahasa pemrograman PHP dan MYSQL .
Sistem Pencarian Penyebaran Media Online Di Media Sosial Menggunakan Metode Levenshtein Distance Berbasis Web
Authors: Handayani Fitri , Qashlim Akhmad , Syarli Syarli
Published: February 2022

Informasi menjadi kebutuhan pokok masyarakat saat ini karena dengan informasi masyarakat dapat mengetahui segala peristiwa yang terjadi di dunia. Permasalahan dalam media sosial di Indonesia adalah ditemukan banyaknya media online yang beredar. Permasalahan dalam media sosial di Indonesia adalah ditemukan banyaknya media online yang beredar. Solusi yang ditawarkan adalah sebuah sistem pecarian dengan sistem ini akan mempermudah pengguna media sosial mengetahui berita apa saja yang pernah tersebar di media facebook. Hasil penelitian ini adalah sebuah system pencarian media online yang bertujuan untuk membantu pengguna sosial media agar mengetahui informasi yang tersebar di media facebook.
SISTEM INFORMASI LAPORAN SURATPERINTAH TUGAS PADA DINAS PENDIDIKAN KABUPATEN MAMASA BERBASIS WEBSITE
Authors: Goa Lindayani Arruan , Sarjan Muhammad , Qashlim Akhmad
Published: February 2022

Salah satu indikator penting untuk mengetahui kinerja APBN adalah dengan mengukur tingkat penyerapan anggaran dalam pelaksanaan anggaran. Besaran bagi anggaran yang dapat direalisasikan dapat mencerminkan berjalannya fungsi-fungsi pemerintahan antara lain mendorong pertumbuhan ekonomi, distribusi yang semakin merata dan stabilitas perekonomian yang makin terjaga. Mengingat pentingnya penyerapan anggaran dalam menggerakkan perekonomian bangsa, maka perlu dilakukan berbagai langkah untuk mendorong percepatan penyerapan anggaran. Peneliti melakukan beberapa observasi terhadap penyusunan atau pengimputan data yang berjalan, penyusunan laporan surat perintah tugas bendahara pengeluaran di Kantor ini dan hasil observasi yaitu masalah yang dihadapi oleh petugas kantor dinass tersebut adalah pada penyusunan laporan Surat Perintah Tugas Perkembangan teknologi informasi semakin mempermudah pekerjaan seseorang yang sebelumnya secara manual, berkat dukungan tekniolgi komputer hal ini dibuktikan dengan mekanisme kerja yang panjang menjadi lebih efektif dan efisien. Baik dalam sumber daya hardware (perangkat keras), software (perangkat lunak) dan brainware (manusia). Berdasarkan latar belakang tersebut maka peneliti mencoba untuk membuat laporan Surat Perintah Tugas dengan menggunakan visual studio. “sistem informasi laporan surat perintah tugas pada dinas pendidikan kabupaten mamasa berbasis website”
Sistem Pendukung Keputusan Pemilihan Menu Makanan Pada Rumah Makan Menggunakan Metode AHP
Authors: Ismanto Juni , Sarjan Muhammad , Qashlim Akhmad
Published: February 2022

Pemilihan menu makanan pada rumah makan yang baik merupakan faktor yang perlu di perhatikan untuk mengoptimalkan perkembangan rumah makan. Dalam hal ini peran pemilik rumah makan sangat dibutuhkan dalam pemilihan menu makanan pada rumah makan. Penentuan menu makanan pada rumah makan di butuhkan beberapa poin seperti kebutuhan pasar (makanan yang lagi tren ), bahan makanan, harga makanan, daya tarik makanan, dan waktu proses pembuatan, seperti halnya yang di lakukan beberapa rumah makan yang ada di Kab.polewali mandar. Tujuan dilakukannya penelitian ini untuk merancang sebuah Sistem Penunjang Keputusan Pemilihan Menu Makanan pada rumah makan menggunakan Metode ANALITYCAL HIERARCHY PROCESS (AHP) berbasis WEB pada warung makan yang ada di KAB. Polewali Mandar. Hasil penelitian ini adalah sebuah sistem yang dapat membantu pihak pemilik rumah makan dalam menentukan jenis menu makanan berdasarkan beberapa kriteria yang telah disebutkan pada bahan penelitian. Dengan adanya sistem pendukung keputusan pemilihan menu makanan pada rumah makan diharapkan dapat membantu pemilik rumah makan dalam memilih menu makanan yang akan di gunakan secara cepat.dan akurat pada rumah makan miliknya.
SISTEM PRESENSI YANG TERINTEGRASI DENGAN PROSES PENGGAJIAN
Authors: Musdalifa Musdalifa , Tamin Rosmawati , Muztazam Andi Emil
Published: February 2022

Melihat perkembangan teknologi yang ada, di Universitas Al Asyariah Mandar tepatnya dibagian keuangan yang aktivitasnya melakukan kegiatan penggajian kepada karyawan atau staf dituntut untuk lebih teliti dalam melakukan perhitungan gaji karyawan. Sistem penggajian yang dilakukan masih menggunakan Ms. Excel untuk menghitung gaji karyawan, dan merekap data-data Karyawan penerima gaji Mesti Detail. Sehingga, di butuhkan system aplikasi berbasis WEB yang bertujuan agar lebih mudah saat melakukan penggajian. Pada tugas penelitian ini dirancang system Program Absensi Yang Terintegrasi Dengan Proses Penggajian menggunakan bahasa pemrograman Javascript, Python dan Firebase berbasis computer agar lebih memudahkan pihak keuangan dalam melakukan penggajian kepada karyawan. Hasil Akhir dari penelitian ini yaitu berupa Slip Penerima Gaji.
penerapan sistem internet of things (IOT) monitoring pada kendaraan
Authors: Rahman Rahman , Syarli Syarli , Burhanuddin Burhanuddin
Published: February 2022

Pertumbuhan Jumlah kendaraan bermotor di Indonesia utamanya yang ada di Kab Polman, Prov Sulawesi Barat, karna padatnya pertumbuhan kendaraan maka sering terjadi pelarian/pencurian kendaraan maka di butuhkan sebuah sistem untuk memonitoring lokasi kendaraan dengan istilah IOT (Internet Of Things). IOT merupakan suatu jaringan internet yang dimana menyediakan, mentransfer dan mengolah informasi digital yang di peroleh dari peralatan sensor seperti Arduino uno R3, GPS Ublox dan Modul GSM 800L. Adapun hasil dari penelitian ini adalah sebuah perangkat yang dapat memonitoring kendaraan melalui GPS dan titik koordinatnya di kirim ke perangkat smarphone.
Model-Model Regresi untuk Mengatasi Masalah Overdipersi pada Regresi Poisson
Authors: Rahayu Ayu
Published: February 2022

Model Regresi Poisson merupakan model standar yang digunakan untuk menganalisis data yang memuat variabel dependen berupa diskrit (count data). Pada regresi Poisson terdapat asumsi yang harus dipenuhi yaitu kesamaan antara nilai mean dan variansinya. Akan tetapi, pada analisis data diskrit yang menggunakan regresi Poisson sering terjadi overdispersi (overdispersion) yaitu keadaan nilai variansnya lebih besar dari nilai meannya. Salah satu penyebab terjadinya overdispersi adalah terdapat kelebihan nilai nol pada variabel dependennya. Adanya overdispersi dalam data menyebabkan nilai prediksi menjadi tidak tepat sehingga distribusi Poisson tidak layak digunakan. Model-model regresi alternatif yang dapat digunakan untuk mengatasi masalah overdispersi adalah dengan menggunakan model regresi Generalized Poisson (GP), Zero Inflated Poisson (ZIP), dan Zero Inflated Generalized Poisson (ZIGP). Dengan membandingkan nilai AIC, Log-likelihood, Pearson Chi Square/DB maka model ZIP lebih baik digunakan untuk mengatasi masalah overdispersi yang disebabkan oleh kelebihan nilai nol pada varaibel dependennya dibandingkan dengan model GP dan ZIGP.
Faktor Yang Berhubungan Dengan Penggunaan Jamban Di Rumah Sakit Umum Daerah Polewali Mandar Kabupaten Polewali Mandar
Authors: Novitasari Dinda , Abidin Urwatil Wusqa , Liliandriani Andi , Nengsi Sri
Published: February 2022

Jamban merupakan bagian terpenting dalam lingkungan manusia, jamban yang tidak sesuai standar badan kesehatan nasional dapat menjadi sumber datangya berbagai penyakit akibat pencemaran lingkungan dari tinja. Penelitian ini bertujuan untuk mengetahui faktor hubungan pengetahuan, kontruksi jamban, kebersihan jamban, dan ketersediaan air bersih dengan penggunaan jamban di Ruang Poli Klinik Rumah Sakit Umum Daerah Polewali Mandar Tahun 2020. Penelitian ini menngunakan jenis penelitian observasional sedangkan pendekatan penelitiannya menggunakan Cross Sectional Study yaitu mengetahui faktor yang Berhubungan dengan Penggunaan Jamban di Ruang Poliklinik UmumRumah Sakit Umum Daerah Polewali Mandar yang diamati pada priode yang sama. Hasil pada penelitian ini menunjukkan dimana ada hubungan faktor pengetahun dengan penggunaan jamban di Ruang Poli Klinik Rumah Sakit Umum Daerah Polewali Mandar dimana nilai P 0,01 < 0,05, Ada Hubungan Faktor Kontruksi Jamban dengan Penggunaan Jamban dimana nilai P 0,040< 0,05, Ada Hubungan Faktor Sanitasi Jamban dengan Penggunaan Jamban dimana nilai P 0,029< 0,05. Serta Ada Hubungan Faktor Ketersediaan Air Bersih dengan Penggunaan Jamban di Ruang Poli klinik Rumah Sakit Umum Daerah Polewali Mandar dimana nilai p 0,002 < 0.05. Kata kunci: Jamban, Rumah Sakit, Faktor, Hubungan