bluuebunny/crossref_metadata_2025 huggingface dataset:
A Model of Cross-Disciplinary Communication for Collaborative Statisticians: Implications for Curriculum Design
Authors: Samsa Gregory P. , LeBlanc Thomas W. , Locke Susan C. , Troy Jesse D. , Pomann Gina-Maria
Published: August 2018

The ability to bridge multiple disciplines is critical to the successful practice of collaborative statistics, yet theliterature on statistical education devotes relatively little attention to how this skill can be taught. Our goal here is todescribe a general conceptual framework within which a curriculum on communication and leadership couldultimately be organized.The primary research question pertains to whether an actionable model of cross-disciplinary communication forcollaborative statisticians can be developed, and our task here is to describe such a model and also to illustrate its use.Within this model most communications either share or request information. For example, statisticians might provideinformation about statistics (e.g., specific statistical approaches, general statistical principles), comment on theclinician’s understanding of statistics, share their understanding of clinical content, and request information (e.g.,about clinical content, the design and execution of the study being discussed, etc.). Clinical investigators contributean analogous set of components. In addition, a critical element to the interaction is the higher-level task ofdeveloping a mutually understood agreement about the work to be performed: in essence, proposing and negotiatingsuch an agreement.The model is illustrated using a case study, and general qualitative feedback from investigators who performed thecase study was obtained, commenting on both successful and unsuccessful interactions with statisticians.Implications for curriculum development are discussed.
Practical Recommendation for the Use of Big Data in Strategic Management: Case Study of a Kazakh Telecommunications Company
Authors: Karimova Gulnara Z. , Kim Yevgeniya
Published: August 2018

This study analyzes the dynamics in the development and use of new, innovative technologies based on big data as they allow companies to expand their range of services, using large amounts of data, which in turn enables them to obtain economic benefits. Big data is often used as a tool for undertaking managerial tactical decisions rather than strategic. Using the practices of a Kazakh telecommunications company as an example, this study demonstrates how the potential of big data is limited to the decision-making tool and suggests how big data technology can improve the efficiency of the strategic management.
Salivary VEGF - A Potential Breast Cancer Marker
Authors: Mondal Subhajit , Santra Sayantan , Ali Md Nasim , Mandal Syamsunder , Mukherjee Ramanuj , Adhikari Anjan , Chatterjee Amitava
Published: August 2018

Aims: To identify and estimate salivary VEGF of breast cancer patients using non invasive method. Methods: ELISA, Zymography, Immunoblot. Results: We observed that saliva of breast cancer patients express appreciably high VEGF compare to non breast cancer saliva samples. Conclusion: The findings indicate salivary VEGF as a potential breast cancer marker using non invasive method.
At Home with the Foreign
Authors: Gaffney Jennifer ,   Philosophy Documentation Center
Published: August 2018

This paper examines Hannah Arendt’s contribution to a conception of political life that remains vigilant of the foreignness that confronts us in our efforts to inhabit a shared world. To this end, I interpret Arendt’s less appreciated discourse on caritas, or love of the neighbor in Love and Saint Augustine, as a critical appropriation of Heidegger’s notion of care. In turning to caritas, I maintain that Arendt captures, perhaps more fully than Heidegger, the foreignness that care is destined to confront in its native desire to belong to something outside of itself. This, I argue, leads Arendt to insist that the responsibility to care is not foremost a matter of individual existence, but rather of politics, grasped precisely as an openness to the foreign in communal life.
The Substance-attributes Relationship in Cartesian Dualism
Authors: Monnoyeur Françoise ,   Philosophy Documentation Center
Published: August 2018

In their book on Descartes’s Changing Mind, Peter Machamer and J. E. McGuire argue that Descartes discarded dualism to embrace a kind of monism. Descartes famously proposed that there are two separate substances, mind and body, with distinct attributes of thought and extension (Principles of Philosophy). According to Machamer and McGuire, because of the limitations of our intellect, we cannot have insight into the nature of either substance. After reviewing their argument in some detail, I will argue that Descartes did not relinquish his favorite doctrine but may have actually fooled himself about the nature of his dualism. It is my contention that the problem with Cartesian dualism stems from the definition of mind and body as substances and the role of their respective attributes—thought and extension—in the definition of substances.
Por que cantam os passarinhos?
Authors: Palhares Juliana Mendonça
Published: August 2018

Tornar a narrativa de si a matéria estruturante para a reflexão e análise do meu próprio sujeito e de sua travessia como artista-professora-pesquisadora. Por que cantam os passarinhos? apresenta  a ação de investigar a minha própria história e dela extrair uma experiência significativa, primordial para o meu caminho de vida e escolha profissional. O ato de debruçar sobre a minha experiência e esmiuçá-la, procurando analisá-la e compreendê-la como um momento existencial vivido em completude, transforma o instante do presente e abre novas possibilidades de construção de sentidos. Num segundo momento do estudo, observei como a minha narrativa provocou o corpo-estético da criança e passou a ser também uma narrativa de outras infâncias.
Memórias docentes: os cheiros e as cores da arte
Authors: Alves Carla Juliana Galvão , Sabino Denise Batista Pinto
Published: August 2018

Este trabalho põe foco nas memórias afetivas de professores de Artes Visuais, com o objetivo de compreender o papel que desempenham na escolha profissional e na constituição de suas identidades docentes. O referencial teórico-metodológico adotado é o da Pesquisa Narrativa, fundamentado principalmente em Josso e Nóvoa. As reflexões apresentadas referem-se às experiências estéticas e/ou artísticas vividas por esses professores em suas trajetórias individuais, e são analisadas à luz de Dewey. A pesquisa evidenciou a importância de tais experiências tanto na educação escolar quanto na formação docente, uma vez que para a construção dos saberes e fazeres em arte implica em uma sensibilização que só é possível por meio de vivências e da elaboração de sentidos que se faz tanto de forma pessoal quanto de forma partilhada nos mais diversos espaços educativos.
“Você sabe ensinar, sim!” Experiência, narrativa e (auto)formação
Authors: Ferreira Luiz Carlos Pinheiro
Published: August 2018

O artigo contempla aspectos de uma investigação arqueológica de si, com ênfase no campo autobiográfico e narrativo, explicitando lembranças emblemáticas que impulsionaram o interesse pela docência em artes visuais. Evoca experiências presentes no processo de (auto)formação subjetiva, suscitando reflexões acerca dos caminhos percorridos durante a época de escolarização. A pergunta que impulsionou a produção desse movimento de escrita corresponde ao momento de enunciação da frase “Você sabe ensinar, sim!” proferida pela Professora Sueli Rezende, no contexto formativo da antiga quarta série do ensino fundamental.
Hebe de Carvalho: Educando os arte/educadores
Authors: Barbosa Ana Mae
Published: August 2018

Este ensaio faz parte de uma pesquisa mais ampla sobre Mulheres Arte Educadoras na década de 60 em Recife, Brasília e São Paulo . A intenção era buscar as marcas impressas deixadas por essas mulheres como artigos escritos por elas ou sobre elas, dissertações, teses, entrevistas , relatos , aulas , etc . Hebe de Carvalho se revela através de entrevista que deu a Carlos Triguis para sua dissertação de mestrado. Hebe foi professora nas mais arrojadas experiências culturais e educacionais de São Paulo como o Museu de Arte de São Paulo (MASP), a Fundação Armando Alvares Penteado(FAAP) ,o Ginásio Pluricurricular Experimental da Lapa  e a Escola Livre de Artes Plásticas  do Juqueri
Agora eu era o herói: imaginação e expressão artística na primeira infância
Authors: Albano Ana Angélica
Published: August 2018

Através de memórias, experiências como e com professores de arte e observações coletadas ao longo de 20 anos supervisionando estágios no curso de graduação em artes visuais da Unicamp, reflito sobre a potência das atividades com linguagem visual na educação infantil. Dialogo com poetas e artistas, procurando imagens que enfatizem a importância de incentivarmos a imaginação e a expressão artística na primeira infância.
Infâncias, quadrinhos e ruralidade: Quatro fragmentos das histórias que vivi para me tornar no que sou
Authors: Charréu Leonardo
Published: August 2018

Este é um artigo escrito na primeira pessoa e adopta uma perspectiva literária, essa mesmo tão defendida por Elliot Eisner, a partir da qual ele, tal como eu, acreditava ser também possível narrar ciência. Por isso, nem Eisner nem Max Van Manen, esse fenomenólogo da educação enquanto experiência vivida, aparecerão a pontuar o meu texto. Mas declaro solenemente que este texto é-lhes devedor da sua substância implícita. Consequentemente, é um texto limpo e vivo, sem vozes de teóricos mortos, que é o mesmo que dizer sem bibliografia. Logo, perigosamente, anti-acadêmico nesse sentido de ter que estar polvilhado de referências, citações e outras meta-narrativas para se considerar “científico”. Busca a coerência da originalidade e é precisamente consciente que a vida de cada um é única e irrepetível. E julgo ser na ligação entre estes fragmentos que se encontrará talvez a resposta ao desafio lançado pela Revista: como nos tornamos arte educadores.
No novelo da memória, atravessamentos do sensível: tornar-se
Authors: Ostetto Luciana Esmeralda
Published: August 2018

As histórias de vida e formação, como construções biográficas, são acessadas por meio de atos de memória e ganham nuanças peculiares no próprio processo de narrar-se, a medida em que o narrador caminha para si. Dentro de tal quadro compreensivo, o artigo é tecido com fragmentos de memórias que contam sobre itinerários de formação – ética, política, estética –, representativos da existencialidade da autora. Ao localizar atravessamentos sensíveis que contribuíram para a ampliação de seus repertórios artístico-culturais em diferentes temporalidades, dá visibilidade à formação estética como processo-projeto de elaboração de sentidos e produção da vida, na relação com a arte, a cultura e a natureza. Na fronteira entre educação e arte, trazendo à mostra traços de percursos singulares, desdobra-se em reflexão sobre a formação de professores.
Anatomia da madeira de três apocináceas da Floresta Estacional de Missiones, Argentina
Authors: Muñiz Graciela Ines Bolzon de , Marchiori José Newton Cardoso
Published: August 2018

The wood anatomy of Aspidosperma australe Müll. Arg., Aspidosperma polyneuron Müll. Arg. and Rauwolfia sellowii Müll. Arg. are described, based on samples collected in the province of Misiones, Argentina. The three species showed the most important anatomic features, cited in the literature for Apocynaceae. Aspidosperma australe is identified by its homogeneous and predominantly uniseriate rays. Aspidosperma polyneuron has mostly biseriate rays and sclerotic tyloses in vessel members. Rauwolfia sellowii shows larger rays and no tyloses in its vessel members.
Belerofontinas (Mollusca: Gastropoda) devonianos do estado do Paraná (formação Ponta Grossa, Bacia do Paraná): gênero Bucanella meek, 1871
Authors: Marchioro Angela , Kotzian Carla Bender , Simões Raquel Ilha
Published: August 2018

In this study, previous records of the genus Bucanella Meek, 1871 species in Devonian beds from Paraná State are revised. Redescriptions are presented to the four species studied: Bucanella laticarinata Knod, 1908, 8ucanella dereimsi Knod, 1908, 8ucanella hapsideus (Clarke, 1913) and 8ucanella quadrilobata (Salte r, 1856). To the last two, new combinations are proposed. 8. quadrilobata is recorded for the first time in the Ponta Grossa Formation. The status of Plectonotus and 8ucanella is discussed. Considerations about the affinities of gastropod taxocoenoses from the Ponta Grossa Formation are presented.
Essai sur le français parlé en Ontario : entre représentations et légitimité
Authors: Boissonneault Julie
Published: August 2018

Pour sa deuxième contribution, Julie Boissonneault, qui a précédemment analysé les contraintes institutionnelles qui entravent l’intention et la réalisation des études universitaires en français en Ontario, se penche ici sur la perception qu’on a de la langue des Franco-Ontariens. La langue française parlée en Ontario fait souvent l’objet d’un discours dépréciatif qui établit la compétence des Franco-Ontariens à l’aune de leurs manquements au français de référence. Or, ce discours, qui ne tient pas compte de l’enjeu de la variation interne de toute langue et des processus naturels d’évolution des parlers, nourrit des représentations à l’égard du parler qui sont souvent partielles ou fausses et qui, en retour, peuvent mener à un sentiment d’incompétence chez le locuteur franco-ontarien. Cet essai propose un regard critique sur la trialectique – « discours épilinguistique / représentation linguistique / sécurité-insécurité linguistique » – et met de l’avant la primauté de la description concertée, détaillée et critique de toute variété de langue dans son aménagement « formel ».
Régis Roy (1864-1944) ou la mise en vers de facéties du terroir
Authors: Pichette Jean-Pierre
Published: August 2018

Pour sa part, Jean-Pierre Pichette verse un nouveau chapitre au dossier de la transposition des récits oraux dans des oeuvres littéraires. À l’analyse des écrits destinés à la jeunesse de l’écrivaine Marie-Rose Turcot (Cahiers Charlevoix 3) et de l’ethnologue Marius Barbeau (Cahiers Charlevoix 4), il ajoute l’examen des « petits contes drolatiques » qu’un autre écrivain d’Ottawa, Régis Roy (1864-1944), a publiés entre 1906 et 1928. Cet auteur affirme avoir tiré « du terroir », donc lui-même entendu, les 132 récits brefs et amusants qu’il a mis en vers dans ses trois recueils. La rusticité de sa poésie découle nettement de la source populaire de son inspiration. Par la comparaison d’un échantillonnage de « petits monologues comiques en prose rimée » avec des variantes relevées dans la tradition orale canadienne-française, cette étude entend démontrer que les ingrédients de son humour sont vraiment les « bons mots du terroir ». En choisissant de mettre en vers des contes facétieux – fabliaux véritables fondés sur des sottises, ruses, quiproquos et calembours – Régis Roy s’est taillé une place originale dans le courant terroiriste de son temps.
La didactique clinique comme mode d’accès aux savoirs des enseignants en ÉPS : le cas de l’enseignement du judo
Authors: Loizon Denis
Published: August 2018

Cette étude à visée exploratoire et compréhensive met en évidence les savoirs personnels des enseignants transmis en cours d’ÉPS. La recherche présente trois vignettes didactiques cliniques d’enseignants spécialistes de judo. Les résultats montrent que ces savoirs personnels se sont construits pendant la pratique sportive du judo lorsque ceux-ci étaient de jeunes pratiquants. Le rôle du « déjà-là expérientiel » et ses effets sur les conceptions des professeurs sont mis en avant, en lien avec les savoirs personnels. Compte tenu des effets déterminants des « déjà-là expérientiels et conceptuels », nous proposons quelques pistes de travail pour la formation initiale des enseignants d’ÉPS.
Prendre en compte l’expérience des enseignants d’ÉPS débutants : enjeux épistémologiques, heuristiques et formatifs
Authors: Buznic-Bourgeacq Pablo
Published: August 2018

Notre contribution, dans cet article, propose de montrer comment l’expérience des enseignants d’ÉPS débutants peut être prise en compte au travers de trois approches, qui dépendent du mode d’appréhension de l’expérience subjective par le chercheur et qui conduisent à identifier spécifiquement leur professionnalité : l’expérience, comme conceptualisation en acte, comme persistance de l’éprouvé et comme dialectique de l’autoposition. Ces trois approches sont questionnées au travers de l’analyse de productions d’enseignants débutants en formation. Le croisement de ces approches conduit à trois projets : 1) épistémologique, identifier leurs contributions respectives à l’appréhension et la problématisation de l’expérience; 2) heuristique, circonscrire la professionnalité des enseignants d’ÉPS débutants et notamment préciser la centralité déjà connue du « contrôle »; 3) formatif, questionner le projet de développement des enseignants débutants sous le registre de l’autonomie.
Les représentations d’élèves du secondaire de la littérature à l’école : portrait de quatre profils distincts de lecteurs
Authors: Miquelon Alexie
Published: August 2018

Les enjeux entourant l’enseignement de la littérature sont multiples. Quels corpus enseigner, et pour quelles finalités? Qu’est-ce qui caractérise la lecture littéraire dans le cadre scolaire? Comment favoriser un rapport positif des élèves à la littérature? Pour connaitre1 les représentations des élèves du secondaire sur ces sujets, nous avons procédé par analyse de classes latentes. Quinze indicateurs de représentations ont été soumis aux participants (n=484). L’analyse de leurs réponses a permis de faire émerger quatre profils et d’identifier les facteurs associés à l’appartenance des participants à ceux-ci. Les résultats montrent la diversité des représentations des élèves et soulignent la pertinence de la valorisation de l’investissement subjectif ainsi que de la diversification des corpus littéraires scolaires.
Familles et dissidences dans l’ultra-orthodoxie isrélienne
Authors: Heymann Florence
Published: August 2018

À partir d’une recherche sur les changements dans les diverses communautés religieuses appartenant à la majorité juive d’Israël, je me suis intéressée aux personnes qui abandonnent l’ultra-orthodoxie, les « sortants vers la question », en étant bénévole au sein d’une association d’aide aux sortants, à Jérusalem. Après une présentation succincte du secteur religieux orthodoxe et ultra-orthodoxe en Israël, l’article présente les tensions et les évolutions qui traversent le monde ultra-orthodoxe et percent des failles dans son système d’enfermement. Le texte se poursuit avec l’analyse de la sortie de l’ultra-orthodoxie, qui s’accompagne toujours d’épreuves et d’expériences douloureuses. D’après les statistiques, 1 300 ultra-orthodoxes quitteraient leur milieu chaque année. Sur ce nombre, 20 % environ se font aider par des associations, les 80 % restants se fondent dans la société environnante et deviennent difficilement repérables. Cette « majorité invisible » relève de trois catégories principales : les dissidents de l’ultra-orthodoxie séfarade, les deuxièmes générations de ceux qui étaient « retournés à la religion », enfin les familles nucléaires, parents et enfants. L’article s’intéressera tout particulièrement à la troisième de ces catégories : les familles entières confrontées à des défis particuliers, qui les obligent bien souvent à mener une double vie.
Re-Making Kinship. From Community to Family
Authors: Roda Jessica
Published: August 2018

The Sephardic Jews living in France, who use Judeo-Spanish as their heritage language, are an assimilated diasporic group that has witnessed war, assimilation and marginalization. With the increase in genealogical research in Western Society, many Sephardim have experienced a process of revitalization of memory through kin relations with people of similar descent. This complex revitalization takes form within the structure of a community cultural centre which acts as a place for re-making kinship thanks to the emotional experience of sharing a specific musical heritage. This phenomenon forces us to examine the tension between « traditional » kinship systems — embodied in the matrilineal bloodline in the case of halakhic Jewish identity — and symbolic kinship anchored in the idea of a « chosen family », to rethink kinship as a mixture between biology and culture, as well as to reconsider current anthropological debates on religion thought beyond the strict religious practices.
« L’ancienne Alliance jamais révoquée » dans les interventions récentes des papes1
Authors: Duhaime Jean
Published: August 2018

Le 17 novembre 1980, au cours d’une rencontre avec les représentants de la communauté juive de Mayence en Allemagne, le Pape Jean-Paul II a décrit le dialogue entre juifs et catholiques comme une « rencontre entre le Peuple de Dieu de l’ancienne Alliance, jamais révoquée par Dieu, et le Peuple de Dieu de la nouvelle Alliance ». Que changeait cette remarque ? Quel a été son impact sur les interventions subséquentes de Jean-Paul II et celles de ses successeurs ? L’auteur présente les principaux textes du Nouveau Testament et des origines chrétiennes qui ont façonné la pensée traditionnelle de l’Église sur le peuple juif. Puis il examine les paroles et gestes de Jean-Paul II et de ses deux successeurs, Benoît XVI et le Pape François. Il signale en terminant la réception de cette déclaration dans divers milieux.
Dans mon parcours, rien ne me destinait à une carrière de traducteur
Authors: Anctil Pierre
Published: August 2018

Jusqu’à tout récemment, la plupart des francophones ignoraient l’existence à Montréal d’une littérature de langue yiddish. Dans cet article, l’auteur explique comment il a découvert les auteurs yiddish canadiens et comment il s’est mis à l’apprentissage de la langue pour traduire leurs oeuvres en français. Il s’attarde en particulier à la signification historique de ces écrits pour l’histoire de l’immigration à Montréal et décrit l’approche qu’il a employée pour réaliser ses premières traductions. Il s’arrête en particulier sur la figure de David Rome, l’archiviste du Congrès juif canadien qui lui a inspiré ses premiers efforts, et à l’oeuvre du poète montréalais Jacob-Isaac Segal qu’il a entrepris de traduire au début des années 1990. Ces travaux ont revêtu une signification symbolique particulière, car ils ouvraient la voie pour la première fois à une meilleure compréhension de la Grande Migration juive est-européenne du début duxxesiècle, et donnaient à lire un univers aux paramètres culturels très différents.
Six Viable Readings from Isaiah 1–39 in the Great Isaiah Scroll (1QIsaa)
Authors: Flint Peter W.
Published: August 2018

In order to illustrate the contribution of the Great Isaiah Scroll from Qumran (1QIsaa) to textual criticism, this paper presents six viable readings for Isaiah 1–39, i.e. variants that most likely represent the original Hebrew text. In assessing the cases of Isaiah 3 : 24 ; 9 : 16 [English 9 : 17] ; 18 : 7 ; 19 : 18 ; 21 : 8 ; 23 : 10, the author takes into account the textual character of the manuscript, the scribal habits of the copyist, the work of scholars and commentaries on the Book of Isaiah, recent translations of Isaiah, as well as the context and the overall sense of the passage. In all six instances — with the possible exception of Isa 19 : 18 — the reading in 1QIsaais found to be compelling. These readings and similar ones should therefore be included as part of the main text of Isaiah (not the apparatus) in future editions of the Hebrew Bible, and part of the main text of Isaiah in future translations (not the footnotes).
Paradigme cynégétique et archaïsme artistique
Authors: Demanze Laurent
Published: August 2018

Dans La Grande Beune (Lagrasse, Verdier, coll. « Jaune », 1996), Pierre Michon prolonge son parcours de la peinture occidentale entrepris depuis Vie de Joseph Roulin (Lagrasse, Verdier, coll. « Jaune », 1988) et achevé avec Les Onze (Lagrasse, Verdier, coll. « Jaune », 2009), mais en s’attachant cette fois aux fresques rupestres. Ce « presque roman » est marqué tout entier par une teneur préhistorique et archaïque, qui transforme le narrateur, un jeune instituteur dans les années 1960, en un chasseur et le récit en une traque érotique : c’est tout ensemble un récit d’éducation interrompu et une quête érotique, transfigurés en parcours cynégétique. Cet article s’attache à suivre ce motif cynégétique, pour en faire, à la suite des travaux de Carlo Ginzburg, le modèle même de la narration. Voilà sans doute pourquoi les figures de l’écriture et du récit graphique entrent pour ainsi dire en concurrence avec les représentations rupestres. Pas de peinture de chasse dans la grotte, mais à défaut, une multiplication de présences animales tout au long du récit.
Penser l’image sous le signe de la chasse
Authors: Cnockaert Véronique
Published: August 2018

Selon Frenhofer, le peintre génial du Chef-d’oeuvre inconnu de Balzac, la peinture, celle qui fait la vie, est un art de la démesure, du dépassement de la limite, du débordement. Nous retrouvons ici un des thèmes du mythe de Diane et Actéon : voir ce qui ne peut être vu, la déesse nue. Le peintre tout comme Actéon est un voyeur, et ce qu’il voit (ou montre) décide de son destin tragique. Cet article voudrait montrer que les enjeux entre le chasseur et le peintre ne sont pas si éloignés les uns des autres. La Belle Noiseuse, qui est le nom que Frenhofer donne à son oeuvre, tout comme la déesse, ne se laisse pas prendre, personne ne peut rendre compte de sa beauté, qui d’ailleurs ne semble exister que par le voile qui la recouvre.
La dernière tentation de saint Antoine
Authors: Lussier Alexis
Published: August 2018

À propos de La tentation de saint Antoine, Roger Caillois croyait reconnaître dans les toutes dernières pages du texte de Flaubert l’expression d’un mimétisme général, une généralisation et une tentation de l’espace. Il apparaît qu’en posant la question du mimétisme, comme il en serait d’un « trouble de la perception de l’espace », c’est-à-dire, en somme, en ramenant le regard au-devant de la question du mimétisme – y voir une pathologie du sensible hantée par la visualité même de l’espace –, revient non pas seulement à « anthropomorphiser » le phénomène, mais plutôt à construire, depuis la question du mimétisme, une certaine disposition subjective où la question du regard se pose en fonction d’un imaginaire de la prédation et de la dévoration. À la conception d’un saint Antoine lyrique devait s’ajouter, pour Caillois, la vision d’un saint Antoine psychasthénique, dont le drame se précise entre désir de disparition et identification à la matière, volonté d’assimilation par le dehors et tentation de faire corps avec l’espace. En même temps, c’est l’espace lui-même qui semble perçu comme une puissance dévorante, un « espace noir », capable de dévorer la personnalité même de celui qui ne se distingue plus du « noir », et dont il est lui-même la proie. Tel saint Antoine, l’animal mimétique, dont Caillois a pu rêver, s’abandonne à la tentation de n’être plus que semblable à la matière, bigarré sur fond bigarré, ou quelle que soit l’image qu’il cède, et qu’il abandonne, dans un espace prédateur où il n’est plus que la négation de lui-même.
« Passer le générique »
Authors: Cormier Landry Jean-Benoit
Published: August 2018

Sur la base d’un rappel de la réception particulière dont a bénéficié la parution, au mitan des années 1990, de Baise-moi (Paris, Florent Massot, 1994), le premier roman de Virginie Despentes, cet article propose une analyse de la dimension autoréflexive du roman avec pour point d’ancrage la scène, centrale dans l’oeuvre, du meurtre du personnage de l’architecte. Il a pour objectif de mettre en lumière les stratégies intertextuelles à l’oeuvre dans le texte qui, en s’articulant aux tactiques éditoriales et de mise en marché du livre au moment de sa parution, ancrent Baise-moi dans le champ des productions culturelles de son époque d’une manière oblique. Dans la perspective ouverte par l’analyse, Baise-moi apparaît, sur les plans esthétique, historique, tout comme sur celui des « politiques de la littérature », dans un fonctionnement dialectique où la surexposition brutale des corps sensibles, sexués et violents ne s’oppose plus à l’entreprise intellectuelle, où la négation forte d’un attachement à l’époque est indissociable d’une inscription complexe dans l’histoire (littéraire et plus largement culturelle) où sont consommés (détruits et assimilés) les codes, les frontières et les hiérarchies d’oeuvres, de médias et de pratiques qui sont ceux d’une modernité faussement porteuse d’émancipation et dont le roman de Despentes dresse un portrait lucide et violent, où ont part simultanément la destruction et l’hommage.
Le spectre de la noblesse
Authors: Martens David
Published: August 2018

Noble d’ancienne lignée, Villiers de l’Isle-Adam s’est volontiers présenté comme étranger à son siècle. Cette posture s’enracine dans un attrait pour la noblesse qui informe l’ensemble de son oeuvre. Ainsi en va-t-il de L’Ève future (1886), qui met en scène une relation problématique entre désir et artifice technologique et conduit à un dénouement occultiste qui conjugue les enjeux d’une poétique du surnaturel et d’un imaginaire nobiliaire. Cette méditation romanesque sur les rapports entre le spirituel et le technologique, mais aussi entre le métaphysique et l’idéologique, se conçoit comme un refus du deuil de l’identité aristocratique et du faisceau de valeurs dont elle est porteuse.
Comment définir le marxisme ?
:
Lecture de Qu’est-ce que j’entends par marxisme
?, d'Alain Badiou, paru aux Éditions sociales en 2016
Authors: Cadet Jean-Jacques
Published: August 2018

Cette lecture met en discussion la définition du marxisme proposée par Alain Badiou.
L’objectif est d'étudier la place de cette théorie dans son système philosophique, et la
manière dont il l’a différenciée du communisme. En définissant le marxisme comme une pensée,
Alain Badiou nous offre une délimitation conceptuelle dont l’interdisciplinarité est
centrale.
On the convergence of solutions to second-order neutral difference equations
Authors: Migda Małgorzata , Migda Janusz , Zdanowicz Małgorzata
Published: August 2018

A second-order nonlinear neutral difference equation with a quasi-difference is studied. Sufficient conditions are established under which for every real constant there exists a solution of the considered equation convergent to this constant.
The existence of consensus of a leader-following problem with Caputo fractional derivative
Authors: Schmeidel Ewa
Published: August 2018

In this paper, consensus of a leader-following problem is investigated. The leader-following problem describes a dynamics of the leader and a number of agents. The trajectory of the leader is given. The dynamics of each agent depends on the leader trajectory and others agents' inputs. Here, the leader-following problem is modeled by a system of nonlinear equations with Caputo fractional derivative, which can be rewritten as a system of Volterra equations. The main tools in the investigation are the properties of the resolvent kernel corresponding to the Volterra equations, and Schauder fixed point theorem. By study of the existence of an asymptotically stable solution of a suitable Volterra system, the sufficient conditions for consensus of the leader-following problem are obtained.
Assessing the capability of Fourier transform infrared spectroscopy in tandem with chemometric analysis for predicting poultry meat spoilage
Authors: Rahman Ubaid ur , Sahar Amna , Pasha Imran , Rahman Sajjad ur , Ishaq Anum
Published: August 2018

Background

Use of traditional methods for determining meat spoilage is quite laborious and time consuming. Therefore, alternative approaches are needed that can predict the spoilage of meat in a rapid, non-invasive and more elaborative way. In this regard, the spectroscopic techniques have shown their potential for predicting the microbial spoilage of meat-based products. Consequently, the present work was aimed to demonstrate the competence of Fourier transform infrared spectroscopy (FTIR) to detect spoilage in chicken fillets stored under aerobic refrigerated conditions.

Methods

This study was conducted under controlled randomized design (CRD). Chicken samples were stored for 8 days at 4 + 0.5 °C and FTIR spectra were collected at regular intervals (after every 2 days) directly from the sample surface using attenuated total reflectance during the study period. Additionally, total plate count (TPC), Entetobacteriaceae count, pH, CTn (Color transmittance number) color analysis, TVBN (total volatile basic nitrogen) contents, and shear force values were also measured through traditional approaches. FTIR spectral data were interpreted through principal component analysis (PCA) and partial least square (PLS) regression and compared with results of traditional methods for precise estimation of spoilage.

Results

Results of TPC (3.04–8.20 CFU/cm2), Entetobacteriaceae counts (2.39–6.33 CFU/cm2), pH (4.65–7.05), color (57.00–142.00 CTn), TVBN values (6.72–33.60 mg/100 g) and shear force values (8.99–39.23) were measured through traditional methods and compared with FTIR spectral data. Analysis of variance (ANOVA) was applied on data obtained through microbial and quality analyses and results revealed significant changes (P < 0.05) in the values of microbial load and quality parameters of chicken fillets during the storage. FTIR spectra were collected and PCA was applied to illuminate the wavenumbers potentially correlated to the spoilage of meat. PLS regression analysis permitted the estimates of microbial spoilage and quality parameters from the spectra with a fit of R2 = 0.66 for TPC, R2 = 0.52 for Entetobacteriaceae numbers and R2 = 0.56 for TVBN analysis of stored broiler meat.

Discussion

PLS regression was applied for quantitative interpretation of spectra, which allowed estimates of microbial loads on chicken surfaces during the storage period. The results suggest that FTIR spectra retain information regarding the spoilage of poultry meat.

Conclusion

The present work concluded that FTIR spectroscopy coupled with multivariate analysis can be successfully used for quantitative determination of poultry meat spoilage.
Critical reduction of the geographic distribution of Cyanocyclas (Cyrenidae: Bivalvia) in Uruguay
Authors: Clavijo Cristhian , Carranza Alvar
Published: August 2018

The South American endemic corbiculid genus Cyanocyclas comprises about 15 nominal species described from Uruguay. Of these, only two are at present considered valid species. Several authors have reported population declines of these species after the settlement and spread of the invasive genus Corbicula, and even the disappearance of Cyanocyclas populations from certain localities.

This article reviews the historical and present geographical distribution of Cyanocyclas spp. in Uruguay. Of the localities where Cyanocyclas spp. have been reported previously, 75% were re‐surveyed during 2009 and 2012, but Cyanocyclas spp. were found to be present in only five of these locations (7.1%).

In addition to Cyanocyclas limosa and Cyanocyclas paranensis, at least three morphotypes not attributable to any of these species were found; therefore, the reduction in range may be more severe than expected.

The putative effect of the invasive bivalve Corbicula fluminea and other stressors is briefly discussed.

The adequate management of the few extant populations is a key issue in ensuring the conservation of Cyanocyclas.
An investigation on additives for pelletizing highly torrefied biomass
Authors: Distler Tobias , Sitzmann Werner
Published: August 2018

The co‐firing of biomass with coal is usually done using white wood pellets. Compared to coal, white wood pellets come with several disadvantages in terms of lower energy density, higher energy required for milling, and less water stability. One possible measure to counteract these disadvantages is torrefaction. As (intensive) torrefaction leads to the destruction of the binding forces in the wood, the addition of a suitable additive for pelletization is required. The utilization of thermoplastics (LDPE, PP, PS, and EVA) as additives for pelletizing highly torrefied wood with an HHV (higher heating value) of 25.1 MJ kg−1 was tested in a laboratory and in pilot plant‐scale pellet mills. In a first step, the behavior of the single thermoplastics mixed with the torrefied biomass was evaluated. The thermoplastics partly led to lubricating effects and partly to retarding effects, and differed in their adhesive behavior. Based on this information, mixtures of thermoplastics were developed and tested. The best results in this study were achieved using an additive mixture containing 5 wt.% LDPE, 1 wt.% EVA, and 5 wt.% PS based on the mass of torrefied biomass. By using this additive mixture and Kahl's pellet mill 33‐390, the production of pellets complying with ISO/TS 17225‐8:2016 was achieved to a large extent. Only the results concerning pellet stability (PDI) did not fully meet the requirements. The pellets produced showed very good water stability and no visible leaching when immersed in water for 72 hours. The HHV of the torrefied biomass was increased due to the addition of high‐calorie additives from 25.1 to 26.8 MJ kg−1. © 2018 Society of Chemical Industry and John Wiley & Sons, Ltd
Enhanced Room‐Temperature Phosphorescence through Intermolecular Halogen/Hydrogen Bonding
Authors: Xiao Lu , Fu Hongbing
Published: August 2018

Room‐temperature phosphorescence (RTP) materials with high efficiency have attracted much attention because they have unique characteristics that cannot be realized in conventional fluorescent materials. Unfortunately, efficient RTP in metal‐free organic materials is very rare and it has traditionally been considered as the feature to divide purely organic compounds from organometallic and inorganic compounds. There has been increasing research interest in the design and preparation of metal‐free organic RTP materials in recent years. It has been reported that intermolecular interactions make a big difference to the photophysical behavior of organic molecules. In this regard, herein, the parameters that affect RTP efficiency are discussed, and a brief review of recent intermolecular halogen‐/hydrogen‐bonding strategies for efficient RTP in metal‐free organic materials are provided. The opportunities and challenges are finally elaborated in the hope of guiding promising directions for the design and application of RTP materials.
Safety and Efficacy of Ledipasvir–Sofosbuvir With or Without Ribavirin for Chronic Hepatitis C in Children Ages 6‐11
Authors: Murray Karen F. , Balistreri William F. , Bansal Sanjay , Whitworth Suzanne , Evans Helen M. , Gonzalez‐Peralta Regino P. , Wen Jessica , Massetto Benedetta , Kersey Kathryn , Shao Jiang , Garrison Kimberly L. , Parhy Bandita , Brainard Diana M. , Arnon Ronen , Gillis Lynette A. , Jonas Maureen M. , Lin Chuan‐Hao , Narkewicz Michael R. , Schwarz Kathleen , Rosenthal Philip
Published: August 2018

Currently, there are no interferon‐free treatments available for hepatitis C virus (HCV)–infected patients younger than 12 years. We evaluated the safety and effectiveness of the all‐oral regimen ledipasvir–sofosbuvir ± ribavirin in HCV‐infected children aged 6 to <12 years. In an open‐label study, patients aged 6 to <12 years received ledipasvir 45 mg–sofosbuvir 200 mg as two fixed‐dose combination tablets 22.5/100 mg once daily, with or without ribavirin, for 12 or 24 weeks, depending on HCV genotype and cirrhosis status. The primary efficacy endpoint was sustained virologic response 12 weeks after therapy (SVR12). Twelve patients underwent intensive pharmacokinetic sampling to confirm the appropriateness of the ledipasvir and sofosbuvir dosages. Ninety‐two patients were enrolled (88 genotype 1, 2 genotype 3, and 2 genotype 4), with a median age of 9 years (range, 6‐11). Most were perinatally infected (97%) and treatment‐naive (78%). Two were confirmed to have cirrhosis, while the degree of fibrosis was unknown in 55 patients. The overall SVR12 rate was 99% (91/92; 95% confidence interval, 94%‐100%). The single patient not reaching SVR relapsed 4 weeks after completing 12 weeks of treatment. The most common adverse events were headache and pyrexia. One patient had three serious adverse events, which were considered to be not related to study treatment: tooth abscess, abdominal pain, and gastroenteritis. The area under the concentration–time curve and maximum concentration values for sofosbuvir, its primary metabolite GS‐331007, and ledipasvir were within predefined pharmacokinetic equivalence boundaries (50%‐200%) compared to values in adults in phase 2/3 of the ledipasvir and sofosbuvir studies. Conclusion: Ledipasvir–sofosbuvir was well tolerated and highly effective in children 6 to <12 years old with chronic HCV.
Patient‐Reported Outcomes and the Economic Effects of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis: The Value Proposition
Authors: Younossi Zobair M.
Published: August 2018

Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) can progress to cirrhosis, hepatocellular carcinoma (HCC), death, or liver transplantation. NASH has also been associated with impaired health‐related quality of life and poses a significant economic burden. Due to the negative clinical and patient‐reported outcomes and economic burden of NAFLD, it is necessary to review this disease through the lens of value‐based care, in which value is proportional to clinical and quality outcomes and inversely proportional to the costs of delivering these outcomes. I review the components of outcomes measured for patients with NAFLD and NASH and relate them to the value proposition, with the aim to deliver optimal patient‐centered care.
Discovery and development of differentially methylated regions in human papillomavirus‐related oropharyngeal squamous cell carcinoma
Authors: Ren Shuling , Gaykalova Daria , Wang Jennifer , Guo Theresa , Danilova Ludmila , Favorov Alexander , Fertig Elana , Bishop Justin , Khan Zubair , Flam Emily , Wysocki Piotr T. , DeJong Peter , Ando Mizuo , Liu Chao , Sakai Akihiro , Fukusumi Takahito , Haft Sunny , Sadat Sayed , Califano Joseph A.
Published: August 2018

Human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (OPSCC) exhibits a different composition of epigenetic alterations. In this study, we identified differentially methylated regions (DMRs) with potential utility in screening for HPV‐positive OPSCC. Genome wide DNA methylation was measured using methyl‐CpG binding domain protein‐enriched genome sequencing (MBD‐seq) in 50 HPV‐positive OPSCC tissues and 25 normal tissues. Fifty‐one DMRs were defined with maximal methylation specificity to cancer samples. The Cancer Genome Atlas (TCGA) methylation array data was used to evaluate the performance of the proposed candidates. Supervised hierarchical clustering of 51 DMRs found that HPV‐positive OPSCC had significantly higher DNA methylation levels compared to normal samples, and non‐HPV‐related head and neck squamous cell carcinoma (HNSCC). The methylation levels of all top 20 DNA methylation biomarkers in HPV‐positive OPSCC were significantly higher than those in normal samples. Further confirmation using quantitative methylation specific PCR (QMSP) in an independent set of 24 HPV‐related OPSCCs and 22 controls showed that 16 of the 20 candidates had significant higher methylation levels in HPV‐positive OPSCC samples compared with controls. One candidate, OR6S1, had a sensitivity of 100%, while 17 candidates (KCNA3, EMBP1, CCDC181, DPP4, ITGA4, BEND4, ELMO1, SFMBT2, C1QL3, MIR129–2, NID2, HOXB4, ZNF439, ZNF93, VSTM2B, ZNF137P and ZNF773) had specificities of 100%. The prediction accuracy of the 20 candidates rang from 56.2% to 99.8% by receiver operating characteristic analysis. We have defined 20 highly specific DMRs in HPV‐related OPSCC, which can potentially be applied to molecular‐based detection tests and improve disease management.
Thyrocyte‐specific deletion of insulin and IGF‐1 receptors induces papillary thyroid carcinoma‐like lesions through EGFR pathway activation
Authors: Ock Sangmi , Ahn Jihyun , Lee Seok Hong , Kim Hyun Min , Kang Hyun , Kim Young‐Kook , Kook Hyun , Park Woo Jin , Kim Shin , Kimura Shioko , Jung Chan Kwon , Shong Minho , Holzenberger Martin , Abel E. Dale , Lee Tae Jin , Cho Bo Youn , Kim Ho‐Shik , Kim Jaetaek
Published: August 2018

Insulin and insulin‐like growth factor (IGF)‐1 signaling in the thyroid are thought to be permissive for the coordinated regulation by thyroid‐stimulating hormone (TSH) of thyrocyte proliferation and hormone production. However, the integrated role of insulin receptor (IR) and IGF‐1 receptor (IGF‐1R) in thyroid development and function has not been explored. Here, we generated thyrocyte‐specific IR and IGF‐1R double knockout (DTIRKO) mice to precisely evaluate the coordinated functions of these receptors in the thyroid of neonates and adults. Neonatal DTIRKO mice displayed smaller thyroids, paralleling defective folliculogenesis associated with repression of the thyroid‐specific transcription factor Foxe1. By contrast, at postnatal day 14, absence of IR and IGF‐1R paradoxically induced thyrocyte proliferation, which was mediated by mTOR‐dependent signaling pathways. Furthermore, we found elevated production of TSH during the development of follicular hyperplasia at 8 weeks of age. By 50 weeks, all DTIRKO mice developed papillary thyroid carcinoma (PTC)‐like lesions that correlated with induction of the ErbB pathway. Taken together, these data define a critical role for IR and IGF‐1R in neonatal thyroid folliculogenesis. They also reveal an important reciprocal relationship between IR/IGF‐1R and TSH/ErbB signaling in the pathogenesis of thyroid follicular hyperplasia and, possibly, of papillary carcinoma.
TERT promoter mutation subtypes and survival in stage I and II melanoma patients
Authors: Andrés‐Lencina Juan J. , Rachakonda Sivaramakrishna , García‐Casado Zaida , Srinivas Nalini , Skorokhod Alexander , Requena Celia , Soriano Virtudes , Kumar Rajiv , Nagore Eduardo
Published: August 2018

Mutations within the promoter of gene encoding telomerase reverse transcriptase subunit are frequent in many cancers including melanoma. Previously, the TERT promoter mutations were shown to associate with markers of poor outcome and reduced survival in patients with primary melanoma. In this study, we investigated the impact of the subtypes of TERT mutations on disease‐free and melanoma‐specific survival in 287 patients with stage I/II nonacral melanoma. Our results showed that of the three TERT promoter mutation subtypes, in multivariate models, the −138/−139 CC > TT tandem mutation associated with worst disease‐free and melanoma‐specific survival. In particular, in combination with BRAF/NRAS mutations, the −138/−139 CC > TT TERT promoter mutation associated with statistically significant poor disease‐free and melanoma‐specific survival with hazard ratios of 6.04 (95% CI 2.03–17.94, p = 0.001) and 12.59 (95% CI 2.18–72.70, p = 0.005), respectively. In contrast to the survival data, luciferase assays showed that the highest activity was observed in experiments with a promoter construct with −124 C > T mutation followed by the −138/−139 CC > TT and −146 C > T mutations, which showed similar activity. Based on previous reports, we speculate that the tandem mutation probably leads to greater genomic instability than the common TERT promoter mutations, hence the association with worst survival. However, the results from the study are only preliminary with limited patient data, therefore, require a cautious interpretation. The observations in this study, if confirmed, could have implications for melanoma patients treated with MAP‐kinase inhibitors.