bluuebunny/crossref_metadata_2025 huggingface dataset:
ENGAGEMENT GURU UNTUK PENINGKATAN KREATIVITAS DI MTS KOTA MADIUN DENGAN ANALISIS SITOREM
Authors: Rais Sasli , Ropiqi Moh. Abdul
Published: November 2024

The research aims to find strategies and ways to improve creativity, by testing the strength of the relationship between teacher engagement and creativity. The study uses a quantitative approach with a correlational research method, with data collection through surveys. Data analysis techniques, using correlational analysis and SITOREM analysis. The research sample was 114 teachers, from a population of 160 teachers at MTs Kota Madiun. Determination of the sample using the Taro Yamane formula, selected using proportional random sampling techniques. The results of the study indicate that there is a positive and significant relationship between teacher engagement and creativity. This means that strengthening teacher engagement will be able to increase their creativity. The results of the SITOREM analysis show that there are indicators of teacher engagement that are a priority to be improved, namely: the job is important, interest in organizational goals, having competence, opportunities for self-development, and high performance for self-esteem. Indicators that need to be maintained/developed are actively participating in their work.
KREATIVITAS GURU DALAM EVALUASI HASIL BELAJAR PENDIDIKAN AGAMA ISLAM PADA SISWA DI UPT SPF SD INPRES MALLENGKERI BERTINGKAT I
Authors: Jannah Miftahul , Abdullah Ahmad , Sijal Mutakallim
Published: November 2024

The purpose of this study was to determine the learning outcomes of Islamic religious education in students and the creativity of Islamic religious education teachers in evaluating Islamic religious education learning outcomes at UPT SPF SD Inpres Mallengkeri Bertingkat I as well as the factors that hinder and support the creativity of PAI teachers in evaluating Islamic religious education learning outcomes. The type of research used is descriptive qualitative method. Data collection techniques in this research are observation, interview, and documentation. The data sources in this research are primary and secondary data sources. While the object of this research is the Islamic Religious Education teacher of UPT SPF SD Inpres Mallengkeri Bertingkat I. The results showed that the learning outcomes of Islamic Religious Education at the school were not significant. The results showed that the PAI learning outcomes at UPT SPF SD Inpres Mallengkeri Bertingkat I were quite good because the scores obtained by students were able to achieve scores above the predetermined passing standard of 70-75. Teachers' creativity in evaluating learning outcomes obtained confirmation that creativity is determined by the factor of choosing the right method such as the use of effective methods and good class management, while the factors that hinder creativity are the lack of student awareness of the importance of evaluation and factors that support creativity are good school conditions and teachers who always provide guidance before the evaluation
PERAN ORANG TUA DALAM MENGATASI KENAKALAN REMAJA STUDI KASUS DI KELURAHAN LETTE KECAMATAN MARISO KOTA MAKASSAR
Authors: Soekarno  , Bahtiar Abd. Rahman , Ridha Abdul Azis
Published: November 2024

The purpose of this study was to determine the role of parents in providing guidance on efforts to overcome juvenile delinquency in Lette Village, Makassar City. The research method uses qualitative with data collection techniques used, namely observation, interviews, and documentation. After that the collected data is analyzed with the stages of data reduction, data presentation and verification or drawing conclusions. The results of this study show that the problems studied are related to the role of parents in overcoming juvenile delinquency. It was found that the role of parents in overcoming juvenile delinquency includes participating in youth religious activities in Lette Village, sports lessons to avoid juvenile delinquency activities at night. The main supporting factors are good communication between parents and children, a harmonious and stable family environment. Various obstacles often hinder the role of parents in overcoming juvenile delinquency in this area. One of the main inhibiting factors is the lack of time between parents and children, the factor of peers who behave badly, the surrounding environment is not good, and the factor of people who have low human resources.
PENGARUH PENERAPAN SISTEM FULL DAY SCHOOL TERHADAP MOTIVASI BELAJAR PESERTA DIDIK DI SMPN 1 BEKASI
Authors: Rasyidin Muhammad , Aldiansyah Muhammad , Shiddiq Noviandana Baihaqi , Putra Purnama
Published: November 2024

The full day school system is a system that can encourage increased learning motivation and character building of students at school, because learning can be done in a longer time. However, through interviews conducted with several teachers and students of SMPN 1 BEKASI, several opinions were found that were against this system. In fact, the various benefits obtained through the implementation of the full day school system still cannot eliminate some of these counter opinions. This study aims to determine the effect of the Full Day School System on learning motivation and student character building at SMPN 1 BEKASI. This study uses a quantitative method with a sample of 29 ninth grade students. So that the filled questionnaire must be 29 data according to the number of samples. This study uses simple regression analysis techniques to test the variable fullday school system on learning motivation. The results stated that there was no significant effect on the implementation of the full day school system on student learning motivation. In many cases, students actually feel exhausted or less focused when school hours are extended without any significant changes in the learning approach or a more conducive learning atmosphere.
A pszichiátria a történelem szellemi áramlataiban
Authors: Tringer László
Published: November 2024

Az emberi közösségek életét zavaró deviáns viselkedésmódok problémája egyidős a történelemmel. A szélsőséges magatartásmódok értelmezése és társadalmi megoldása vallási, orvosi vagy rendészeti jellegű közösségi reakciókat eredményezett. E három beszédmód végigkíséri az emberiség történetét, és jelentőségük, egymáshoz viszonyított súlyuk változó. Az orvosi értelmezési keret viszonylag későn önállósodott, és napjainkban ismét visszaszorulóban van. Az orvosi szolgáltatások szinte finanszírozhatatlan fejlődése következtében a kormányzatok korlátokat állítanak, amely korlátok a mentális betegekkel kapcsolatos intézményeket különösen is érintik. Ugyanakkor a mentális problémák rendészeti vagy szociális jellegű kezelése a társadalmakat az orvosi ellátásnál nagyobb költségekkel terheli.
Elementality and the Politics of Light
Authors: Sallis John
Published: November 2024

The essay begins by recalling the words of Homer that to live is to behold the light of the sun. For it is the ‘elementals’ of sky, sun, and light that give all things to mortal beings, including time itself, beginning with the daily alternation between day and night. But contemporary commercial and scientific projects threaten to change all this. Whether it be through the launching of tens of thousands of communication satellites to fill the night sky or the creation of a sulfuric blanket in the atmosphere to block the sun’s rays to combat global warming, what is threatened is our very relationship to the sun and to light. The essay thus argues that what is today needed is a new ‘politics of light’, one that would guard the clarity of the sky. Needed as well is a philosophy that attends to things beyond the human life-world, to the elementals of sun, sky, and light, but also to the invisibility at the heart of light itself. Appealing to some of the most recent scientific discoveries regarding the hyper-giganticness of the cosmos, the essay concludes that philosophy must attend to ‘phenomena’ whose nature is precisely to remain concealed, phenomena such as black holes, dark matter, and dark energy that are today thought to comprise an astonishing 95% of the matter and energy of the universe. Turned in this direction, the essay concludes, philosophy can perhaps reawaken the wonder that is at its very origin.
Notes on Jean-Luc Nancy's Acosmology
Authors: Schuback Marcia Sá Cavalcante
Published: November 2024

This essay engages with the question of how to open a sense of the world that would be capable of de-totalizing the world’s totalization. It discusses the works of Jean-Luc Nancy on the end of the sense of the world today and on the way this end and the void it exposes existence to are already an open sense, the open sense of existence existing—transitively—every single existence. The void of sense demands the distinction between sense and signification or meanings, proposing sense as the praxis of transitive existence. It opens an open sense of the open itself by reconsidering the difference between world and cosmos and by showing the urgency of thinking today an acosmic cosmology or a acosmology that would correspond to this praxis of transitive existence.
The Space Before the World: Spacing, Archi-texture, and Other Questions of Sexual Difference
Authors: Londoño-Becerra Maria-Victoria
Published: November 2024

This paper investigates the intersection of architecture, philosophy, and sexual difference in Plato’s notion of khōra as it appears in the Timaeus. By engaging first with Jacques Derrida's deconstruction of Plato’s khōra, the paper shows how the interplay between architecture and philosophy not only reflects but also perpetuates patriarchal structures. Khōra, sometimes solely described as a passive receptacle, stages a complex relationship with femininity that challenges traditional notions of space and identity. Drawing on the works of feminist theorists such as Julia Kristeva and Fanny Söderbäck, the paper examines how khōra serves as a foundational moment in the construction of sexual difference within philosophical discourse. Ultimately, this exploration calls for a reimagining of khōra as a site of resistance and transformation—one that, while existing before the architect-demiurge created the universe, nonetheless conditions his work.
Paul de Man’s Rigour and Marcel Proust’s Metaphors
Authors: Normandin Shawn
Published: November 2024

Paul de Man’s interpretation of Proust’s metafigural argument is fundamentally correct. Both critics of this interpretation and some of de Man’s defenders have misunderstood how metaphor functions in Proust’s reminiscence of summer, which uses resemblance to evoke reconciliatory totalities. Proust’s passage contains classical metaphors—not synecdoches that merely resemble metaphors. But de Man’s attempts to justify his interpretation are unpersuasive. Indeed, they are so unpersuasive that they become allegorical: though he claims that there is an undoing of metaphor by metonymy in Proust’s text, de Man’s own text relies on metaphor. Detractors like John Guillory are wrong about Proustian metaphor, but they discern some of the genuinely aberrant features of de Man’s discourse. Allegories of Reading allegorically subverts claims made for de Man’s rigour, which is a dead metaphor susceptible to the kind of rhetorical reading he performs on Proust.
Ar. Th. H. 61. Artesanía, sexo y crítica literaria en la Comedia Aristofánica
Authors: Labiano Ilundain Mikel
Published: November 2024

El verso Ar. Th. 61
Household fuel use, smoking and prevalence of self-reported allergic rhinitis in university students in Palestine: a cross-sectional study
Authors: El Sharif Nuha , Hnaihen Lana
Published: November 2024

Purpose

In Palestine, few studies investigated the prevalence of allergies and the factors associated with their occurrence. An online survey was conducted on health complex University students in Jerusalem to determine the prevalence of allergy rhinitis (AR) and its relationship with indoor environmental exposures.

Methods

This study employed a modified online Google form of the Global Asthma Network's Adult Questionnaire. The data were reported as frequency and percentage. The chi-square test of independence was performed to investigate the association between AR diagnosis and other factors. Multivariable models were used to identify the independent risk factors for AR after adjusting for potential confounders.

Results

Data was collected from a total of 819 participants. The mean age of the participants was 20 ± 2 years and 78.1% (n = 640) were females. The AR diagnostic rate was 10.3%. In addition, having asthma and eczema were found to be substantially associated with AR. Additionally, a family history of AR and other allergens were major predictors of AR. The findings revealed that utilizing animal dung for heating increased the likelihood of AR fourfold (AOR = 4.870, p-value = 0.004), whereas e-cigarette vaping increased the possibility of AR by 2.5 times. However, using natural gas for cooking was not significantly associated with AR, and participant age was only slightly associated with AR diagnosis.

Conclusions

Our study found that the AR prevalence rate is low when compared to the same population in other countries. Genetics, biomass fuel consumption, and e-smoking are all significant risk factors for AR in Palestine. An awareness campaign must be developed to educate university students and the general public about the risks of smoking, indoor air pollution, respiratory disorders, and AR. Longitudinal research is required to discover whether these associations are only transient.
Solution analysis for non-linear fractional differential equations
Authors: Kebede Shiferaw Geremew , Guezane Lakoud Assia , Yesuf Haider Ebrahim
Published: November 2024

In this research study, two new types of fractional derivatives, the Caputo-Fabrizio derivative that does not involve a singular kernel (like the Riemann–Liouville derivative), which helps in eliminating some drawbacks, such as non-locality, and the Atangana–Baleanu–Caputo (ABC) derivative that uses a non-singular and non-local kernel, offering different characteristics from other fractional derivatives and often leading to more accurate models in certain physical systems, are used. The primary goal of the research is to analyze a non-linear fractional differential equation involving the fractional derivatives of Caputo–Fabrizio and ABC admit at least one solution. Fixed point theory is a fundamental tool in mathematical analysis used to prove the existence of solutions to various equations. Hence, in this study, to achieve the desired results, we employ a novel fixed point theory known as the F-contraction type. The study also includes required conditions and inequalities that need to be satisfied to ensure that a solution exists. One of these conditions is based on the Lipschitz hypothesis. Therefore, we provide the required conditions and inequalities, based on the Lipschitz hypothesis, to show that solutions to our problem exist. Furthermore, we provide two illustrative examples to support our primary findings.
Protein trans-splicing: optimization of intein-mediated GFP assembly as a model for the development of gene therapy
Authors: Brovin Andrew , Minskaia Ekaterina , Sabantsev Matvei , Chuvpilo Sergey , Karabelsky Alexander
Published: November 2024

Adeno-associated virus (AAV)-based gene therapy has become one of the key directions of modern translational medicine geared towards treatment of hereditary disorders by means of gene replacement. At the moment, about 5,000 different syndromes are associated with mutations in large genes, which presents a great problem due to the AAV packaging capacity of 5 kilobases. The main strategies for overcoming this obstacle were the creation of truncated gene versions, overloading the viral vector, and separate delivery of partial genetic material to restore the whole gene at the level of DNA, RNA, or protein. At present, genome editing via prime editors, most effectively delivered by AAV, relies on the intein pair used to restore the protein complex. The amazing integration speed of intein-based protein trans splicing technology makes it a versatile tool for a variety of applications, albeit not always successful on the first attempt. This study discusses the key points of working with Ssp, Npu, and Ava inteins of the DnaE group, known as the most effective for assembly of large proteins. Using green fluorescent protein (GFP) as a model, we demonstrate that the successful protein assembly requires not only cysteine at position C+1 but also certain aminoacid residues on either side in its immediate environment. Furthermore, the conformation of extein-intein composition, difficult to predict by computer modeling, has an additional effect, as demonstrated by experimental tests of the three split sites optimal in amino acid composition. The NpuDnaE variant demonstrated the highest kinetics of interaction between the N and C parts in the DnaE group of inteins. Optimization of conditions using NpuDnaE intein led to GFP assembly in 80% of transfected HEK293 cells and in 55% of AAV5-transduced cells, as demonstrated by flow cytometry. The efficiency of GFP assembly post-plasmid DNA transfection or AAV transduction of the HEK293 cell line was 15% higher than that of the ARPE19 cell line. We hope that the obtained data will facilitate the development of gene therapies for the treatment of hereditary disorders caused by mutations in large genes.
Application of tight membrane extraction for amines separation
Authors: Salvador Cob Sara , De Sitter Kristien , Buekenhoudt Anita
Published: November 2024

Chiral amines are very valued constituents of many important pharmaceutical compounds and their intermediates. However, the production of a chiral amine encounters some challenges, like the use of harsh conditions and the unfavorable thermodynamic equilibrium. In this research the possibilities of tight membrane extraction (ME) for amines separation has been investigated to improve the reaction equilibrium. A specific transaminase reaction was selected for the study in which product amine 1-methyl-3-phenylpropylamine (MPPA) or methyl benzylamine (MBA) needs to be separated from the donor amine isopropylamine (IPA). Tight ME is an innovative separation process in which the membrane is not only an interface, but also a way to add extra selectivity to the process. In the present work, we thoroughly discuss the main factors influencing this novel technique by evaluating the extraction efficiency and extraction rates for the different amines. Then we also determine the optimal parameters for the selected reaction. Supported liquid membrane extraction (SLM), as well as pressure driven filtration, more specifically, nanofiltration (NF), were also studied as benchmark technologies, showing that tight ME has a greater advantage over the two in this specific case, due to the extra affinity factor offered by the membrane. The selectivity of MPPA/IPA in tight ME for the optimized parameters was significantly higher than for SLM and NF.
The tigecycline resistance mechanisms in Gram-negative bacilli
Authors: Wang Zhiren , Li Henan
Published: November 2024

Tigecycline, hailed as a pivotal agent in combating multidrug-resistant bacterial infections, confronts obstacles posed by the emergence of resistance mechanisms in Gram-negative bacilli. This study explores the complex mechanisms of tigecycline resistance in Gram-negative bacilli, with a particular focus on the role of efflux pumps and drug modification in resistance. By summarizing these mechanisms, our objective is to provide a comprehensive understanding of tigecycline resistance in Gram-negative bacilli, thereby illuminating the evolving landscape of antimicrobial resistance. This review contributes to the elucidation of current existing tigecycline resistance mechanisms and provides insights into the development of effective strategies to manage the control of antimicrobial resistance in the clinical setting, as well as potential new targets for the treatment of tigecycline-resistant bacterial infections.
Catheter ablation for atrial tachycardia in pediatric patients: a single-center experience
Authors: Chen Ruoyu , Xu Xin , He Shuang , Liu Qian , Liu Lin , Zhang Qin , Lu Tiewei
Published: November 2024

Purpose

Atrial tachycardia is an uncommon supraventricular tachycardia in children. It is often drug-resistant and likely to occur concomitantly with tachycardia-induced cardiomyopathy, making radiofrequency catheter ablation the preferred treatment. The aim of this study was to assess the feasibility, safety, and effectiveness of radiofrequency catheter ablation for the treatment of different types of atrial tachycardia in children, particularly in those with drug-resistant and tachycardia-induced cardiomyopathy.

Methods

A total of 28 children with atrial tachycardia (including focal atrial tachycardia and atrial flutter) who underwent atrial radiofrequency ablation at the Children's Hospital Affiliated to Chongqing Medical University from May 2018 to December 2023 were included. The baseline characteristics, preoperative medication, surgical information, and postoperative follow-up data of these children were analyzed statistically.

Results

The mean age patients at ablation was 10.24 ± 3.40 years. A total of 78.6% of the patients (22/28) who received preoperative pharmacological treatment had intermittent or persistent atrial tachycardia. Of the 28 children who underwent radiofrequency ablation, 24 (85.7%) were diagnosed with focal atrial tachycardia, three (10.7%) with atrial flutter, and one (3.6%) with both. No postoperative complications occurred in any patient. The immediate ablation success rate in the 25 patients with focal atrial tachycardia was 96.0% (24/25). After 26.89 ± 18.17 months of follow-up, only three patients had recurrence. The ablation difficulty of focal atrial tachycardia originating in the appendage was higher than that originating in the non-atrial appendage (44.4% vs. 6.3%, p = 0.01). The success rate of ablation for atrial flutter was 100%, except in one child with underlying cardiomyopathy who experienced recurrence. Final success was achieved in 25 of the 28 patients (89.2%) at the end of the follow-up period. In addition, eight children (28.6%) in this study were diagnosed with tachycardia-induced cardiomyopathy, with significantly increased ejection fraction and shortening rate after radiofrequency ablation (p < 0.01), whereas the left ventricular end-systolic diameter were not significantly reduced during the follow-up period (p > 0.05).

Conclusion

Radiofrequency catheter ablation is safe and effective for the treatment of atrial tachycardia in children in the short- and long-term.It can be used as the first treatment option for children with medically refractory atrial tachycardia and tachycardia-induced cardiomyopathy.
Salvage of cardiopulmonary collapse caused by ethanol sclerotherapy for vascular malformations: clinical experience at a single center and literature review
Authors: Su Lixin , Zhao Yan , Shen Yuchen , Fan Xindong , Wang Zhenfeng , Wang Deming , Li Qingyang
Published: November 2024

Objective

This review aims to summarize the salvage experience of cardiopulmonary collapse occurring as a result of absolute ethanol sclerotherapy for vascular malformations.

Methods

In total, we reviewed three cases of cardiopulmonary collapse induced by ethanol sclerotherapy for vascular malformations and described the details of the salvage procedure. Saturation of pulse oxygen (SpO2), end-tidal CO2, and invasive arterial pressure were the routine monitors for ethanol injection patients. Cardiopulmonary resuscitation, epinephrine, norepinephrine, and deoxyepinephrine were mainly used to correct circulation parameters. Manually ventilated via endotracheal intubation with 100% O2, increased respiratory rate were mainly used to correct Respiratory parameters.

Results

All three cases were successfully salvaged without major complications. When cardiopulmonary collapse occurred, manual ventilation via endotracheal intubation with 100% O2, increased ventilation frequency and external cardiac compression were the emergency treatments. Epinephrine, norepinephrine, deoxyepinephrine infusion solely or combined were crucial to maintaining the basic vital signs.

Conclusion

Despite the severity of cardiopulmonary collapse caused by ethanol sclerotherapy, it can be detected by close observation and reversed with timely treatment.
Predictors of beginning teachers’ teaching performance
Authors: Bacus Remedios C. , Picardal Marchee T. , Perez Noremay B. , Balo Vincent Theodore M.
Published: November 2024

Introduction

Quality education hinges on teacher quality. The multifaceted nature of teachers’ roles and their teaching performance necessitates a comprehensive exploration of factors influencing overall education quality.

Methods

This study employed a regression research design, utilizing an expert-validated survey questionnaire completed by 2,680 beginning teachers from the Department of Education across 16 regions in the Philippines. The study aimed to identify personal, educational, and professional characteristics that predict teaching performance as measured by the Results-based Performance Management System (RPMS).

Results

The analysis revealed that among various characteristics, socioeconomic status (personal), grade point average (educational), and both the grade level taught and length of service (professional) were significant predictors of teaching performance.

Discussion

The findings underscore the need for teacher education institutions to adapt curricular delivery in a manner that reflects the practical realities of teaching and acknowledges situated learning. Recommendations include the development of quality assurance mechanisms, academic coaching and mentoring programs, and initiatives to strengthen financial literacy among pre-service teachers to enhance their future teaching performance.
Personalized nutrition in type 2 diabetes remission: application of digital twin technology for predictive glycemic control
Authors: Shamanna Paramesh , Joshi Shashank , Thajudeen Mohamed , Shah Lisa , Poon Terrence , Mohamed Maluk , Mohammed Jahangir
Published: November 2024

Background

Type 2 Diabetes (T2D) is a complex condition marked by insulin resistance and beta-cell dysfunction. Traditional dietary interventions, such as low-calorie or low-carbohydrate diets, typically overlook individual variability in postprandial glycemic responses (PPGRs), which can lead to suboptimal management of the disease. Recent advancements suggest that personalized nutrition, tailored to individual metabolic profiles, may enhance the effectiveness of T2D management.

Objective

This study aims to present the development and application of a Digital Twin (DT) technology—a machine learning (ML)-powered platform designed to predict and modulate PPGRs in T2D patients. By integrating continuous glucose monitoring (CGM), dietary data, and other physiological inputs, the DT provides individualized dietary recommendations to improve insulin sensitivity, reduce hyperinsulinemia, and support the remission of T2D.

Methods

We developed a sophisticated DT platform that synthesizes real-time data from CGM, dietary logs, and other biometric inputs to create personalized metabolic models for T2D patients. The intervention is delivered via a mobile application, which dynamically adjusts dietary recommendations based on predicted PPGRs. This methodology is validated through a randomized controlled trial (RCT) assessing its impact on various metabolic markers, including HbA1c, metabolic-associated fatty liver disease (MAFLD), blood pressure, body weight, ASCVD risk, albuminuria, and diabetic retinopathy.

Results

Preliminary data from the ongoing RCT and real-world study demonstrate the DT’s capacity to generate significant improvements in glycemic control and metabolic health. The DT-driven personalized nutrition plan has been associated with reductions in HbA1c, enhanced beta-cell function, and normalization of hyperinsulinemia, supporting sustained T2D remission. Additionally, the DT’s predictions have contributed to improvements in MAFLD markers, blood pressure, and cardiovascular risk factors, highlighting its potential as a comprehensive management tool.

Conclusion

The DT technology represents a novel and scalable approach to personalized nutrition in T2D management. By addressing individual variability in PPGRs, this method offers a promising alternative to conventional dietary interventions, with the potential to improve long-term outcomes and reduce the global burden of T2D.
A case report of hemosuccus pancreaticus: the cause of upper gastrointestinal bleeding demystified after 9 months of episodic bleeding
Authors: Mukanumviye Marie Solange , Nyampinga Dyna , Ingabire Zainab , Kwitonda Cedric , Shikama Felicien , Rutaganda Eric , Redae Berhane , Aberra Hanna , Musabende Marcellin , Crook Peter , Mbanzabugabo Jean de Dieu , Getaneh Ferehiwot Bekele , Nshizirungu Jean Jacques
Published: November 2024

Hemosuccus pancreaticus is a rare but potentially fatal cause of upper gastrointestinal (GI) bleeding. It is defined as bleeding from the pancreatic duct with blood draining into the duodenum through the ampulla of Vater. In patients with pancreatitis, peri-pancreatic blood vessels may be inflamed by pancreatic enzymes and form a pseudoaneurysm which can rupture and bleed into the pancreatic duct. We report a case of a 43-year-old man who presented with episodic upper GI bleeding of unclear etiology over 9 months without a clear documented history of pancreatitis. The etiology remained elusive even after multiple upper and lower endoscopies. Computed tomography angiography of the abdomen and pelvis during an acute episode detected a pseudoaneurysm of the gastroduodenal artery (GDA) with contrast extravasation into the dilated pancreatic duct. The pseudoaneurysm was treated with coil embolization, resulting in a persisting resolution of the patient’s symptoms. Clinicians should consider abdominal angiography when diagnosing obscure GI bleeding.
The spatiotemporal changes of crab community in the Yangtze River Estuary after the fishing ban
Authors: Yang Zuchang , Feng Guangpeng , Yang Gang , Zhang Tao , Zhao Feng , Geng Zhi , Li Xia , Tan Qingyuan
Published: November 2024

The Yangtze River Estuary is the traditional habitat of fishery resources in China and also one of the crab fishing sites, but nowadays the crab resources have been seriously affected by high-intensity anthropogenic disturbance. To understand the composition and diversity of crab community following the fishing ban, six surveys were conducted from August 2022 to November 2023 using the single-bag trawl method. This study examined the crab community composition, biodiversity, resource density, spatiotemporal distribution patterns, and main influencing factors. Results indicated that a total of 14 crab species lived in the Yangtze River Estuary. Matuta planipes and Portunus trituberculatus were dominant crabs in summer 2022. P. trituberculatus, Eriochier leptognathus, and Charybdis japonica were dominant crabs in autumn 2022. Then, E. leptognathus and Eriocheir sinensis were dominant crabs in winter 2023. Notably, the largest numbers of dominant crabs appeared in spring 2023, including M. planipes, P. trituberculatus, E. leptognathus, C. japonica, and E. sinensis. Three same dominant crabs (M. planipes, P. trituberculatus, C. japonica) were identified in the summer and autumn of 2023. Thereinto, P. trituberculatus was the most dominant crab. The abundance and biomass trends of estuary crabs were winter< spring< autumn< summer. The community diversity index, evenness index, and richness index were winter< summer< autumn< spring, indicating the seasonal changes in abundance, biomass, and biodiversity. Correlation and redundancy analysis revealed that dissolved oxygen and salinity were the most critical environmental factors, which affect the changes in crab community in the estuary. This study revealed the changing characteristics of crab resources in the Yangtze River Estuary after the fishing ban, and provided the essential data and scientific basis for resource conservation and management decisions.
Use of isotopic and elemental fingerprints for seahorse species discrimination and traceability of geographic origin
Authors: Cabral Ana Elisa , Calado Ricardo , Palma Jorge , Ricardo Fernando , Ferreira da Silva Eduardo , Patinha Carla , Planas Miquel
Published: November 2024

Seahorses (Hippocampus spp.; Family Syngnathidae) are mainly targeted by Traditional Chinese Medicine, curio and ornamental trade, as dried or live specimens. Traceability tools may help fill the gaps on supply chains, securing information on geographic origin and identification of traded specimens. Fin-clipping, a non-lethal and well-established method in seahorse research, offers a potential approach to trace the geographic origin and certify the aquaculture of these flagship species. As such, this study aimed to investigate the existence of differences in isotopic profiles of four seahorse species cultured at research centers located in southern Portugal and northern Spain, as well as between cultured Hippocampus guttulatus sourced from two research centers, and between wild and cultured specimens of this species. This research also evaluated the potential of combining isotopic and elemental fingerprints for seahorse species discrimination, through inductively continuous-flow isotope ratio mass spectrometry (IR-MS) and plasma mass spectrometry (ICP-MS). Species cultured at the same research centers exhibited similar stable isotope composition (δ13C and δ15N), except in the case of temperate H. guttulatus from northern Spain, which differed significantly from tropical species H. kuda and H. reidi. These differences could be due to phylogenetic dissimilarities and differences in seawater temperature. The δ15N composition allowed to discriminate between cultured H. guttulatus from the two research centers and between cultured and wild specimens. While dorsal fin isotopes alone did not prove to be a reliable tool for the discrimination of different cultured species, combining them with elemental profiles from seahorses’ whole-body allowed to successfully discriminate between H. kuda and H. reidi. This preliminary research demonstrates the potential of stable isotope and elemental analyses for tracing seahorses’ geographic origin and species identification. However, further research should be performed to validate these findings for wild specimens, particularly those from illegal, unreported and unregulated (IUU) fisheries and trade.
Effects of oyster shell addition on shrimp aquaculture and the dynamic succession of surface biofilm microbial communities
Authors: Huang Xianke , Xiao Guoqiang , Zhang Xiang , Teng Shuangshuang , Li Min , Cai Yilong , Chen Ran , Huang Xiaolin
Published: November 2024

Introduction

In the context of Litopenaeus vannamei aquaculture, the incorporation of oyster shells has proven beneficial for enhancing water quality and the growth conditions of the shrimp. Nonetheless, the specific effects of in-situ water treatment using oyster shells on water quality and shrimp growth, along with the composition and succession dynamics of the microbial community within oyster shell biofilms, have yet to be thoroughly investigated.

Methods

This study established control, low-concentration, and high-concentration oyster shell addition groups to emulate the in-situ water treatment environment with oyster shells, with the objective of elucidating the impacts of oyster shell addition on the aquaculture setting.

Results

The results showed that the addition of oyster shells could significantly improve the length (F = 12.248, P = 0.005), weight(F = 138.234, P < 0.001), and survival rate (F = 15.248, P < 0.001) of shrimp, while there were no significant differences in the length (F = -1.233, P = 0.267) and survival rate (F = -2.143, P = 0.076) between the high and low concentration groups. Additionally, oyster shell addition resulted in elevated phosphate levels (F = 74.92, P < 0.001 in Day 70), diminished nitrite levels (F = 5.276, P = 0.031 in Day 56), and increased nitrate concentrations (F = 9.421, P = 0.006 in Day 70). Within the biofilms, the relative abundances of Ruegeria, Tenacibaculum, BD2- 11_terrestrial_group, and Kapabacteriales exhibited significant declines over time, whereas the relative abundance of Nitrospira demonstrated a marked increase, ultimately emerging as the predominant bacterium (Relative abundance 31.8%) in the biofilms during the latter stages of the experiment. Nitrospira also exhibited a notably higher relative abundance in the microbial community of the experimental water group relative to the control group (F = 2.265, P = 0.001).

Discussion

The biofilm provided conditions for the proliferation of Nitrospira, thereby accelerating the transformation of nitrite into nitrate in the aquaculture system, which subsequently improved the shrimp farming conditions. This research offers valuable insights for the application of oyster shells in shrimp farming and contributes to the theoretical underpinnings necessary for advancing our understanding of the mechanisms through which oyster shell biofilms enhance water quality and foster shrimp health.
Incidence and predictors of mortality among patients admitted to adult intensive care unit at public hospitals in Western Ethiopia: a retrospective cohort study
Authors: Kebede Fetene , Mosisa Getu , Yilma Mekdes
Published: November 2024

Introduction

In resource-constrained countries, the incidence of mortality among patients admitted to adult intensive care units is higher than that in developed countries, which has a physical, economic, and emotional impact on the lives of patients and their families. However, there is limited evidence on factors related to nursing care that can potentially contribute to predicting and reducing mortality rates in intensive care units. Therefore, this study aimed to assess the incidence of mortality and its predictors in patients admitted to an adult intensive care unit.

Methods

A retrospective cohort study was conducted among 403 patients admitted to the adult intensive care unit from 1 January 2021 to 31 December 2021. The collected data were entered into Epi Data Manager v4.6.0.6 and exported to SPSS version 24 for analysis. Binary logistic regression was used to identify the predictors of mortality. Variables with a p-value less than 0.25 in bivariable logistic regression were selected for multivariable logistic regression. A p-value <0.05 was used to indicate a significant association in multivariable analysis. Finally, the adjusted relative risk (RR) with 95% CI was calculated.

Results

A total of 403 patients were included in the analysis. The cumulative incidence of death was 40.9% (95% CI 36, 45.9%). Mortality was significantly associated with the need for mechanical ventilation (adjusted RR = 1.45; 95% CI: 1.04, 1.85), the Glasgow Coma Scale score < 8 (adjusted RR, 3.52; 95% CI: 2.90, 4.05), presence of comorbidity (adjusted RR, 1.47; 95% CI: 1.09, 1.83), length of stay in ICU < 24 h (adjusted RR, 1.84; 95% CI: 1.37, 2.04), oxygen saturation level, and Feeding, Analgesia, Sedation, Thrombosis prophylaxis, Head elevation, Ulcer prophylaxis, and Glucose control (FASTHUG) treatment received were significantly associated with mortality.

Conclusion

The study found a high incidence proportion of death. The need for mechanical ventilation, length of stay, comorbidity, and the Glasgow Coma Scale score were significantly associated with mortality. Therefore, close monitoring and evaluation of patients are essential to improve treatment outcomes.
Application of ventriculoscopy in granulomatous amoebic encephalitis: a case report in China and literature review
Authors: Zheng Zequan , Chen Fajun , Qin Lulu , Lu Aili , Xu Haoyou , Zhao Min , Zhao Yuanqi
Published: November 2024

Balamuthia mandrillaris is a kind of brain-eating amoeba leading to granulomatous amoebic encephalitis (GAE) with a high mortality rate and limited effective treatment options. Its underlying pathological mechanisms are still poorly understood. Here, we presented a 58-year-old man with Balamuthia mandrillaris meningoencephalitis, who died 33 days after onset. In this unique case, we introduced the use of ventriculoscopy in the treatment of B. mandrillaris meningoencephalitis. Through ventriculoscopy, we observed that the inflammatory response triggered by the disease was diffuse and extensive throughout the ventricles and meninges, not limited to the region of parasite invasion. Furthermore, under the precise guidance of ventriculoscopy, we implemented drug lavage therapy and intraventricular drainage, which, to a certain extent, managed to mitigate the progression of hydrocephalus and intracranial hypertension. Despite the unfortunate outcome of the patient’s death due to brainstem hemorrhage, we reiterate the crucial role that surgical intervention plays in both diagnosing and managing amoebic encephalitis. This underscores the need for continued research and innovation in surgical techniques to enhance patient outcomes and combat this challenging neurological condition.
Poor treatment outcomes of acute exacerbations of chronic obstructive pulmonary disease and their associated factors among admitted patients in East Gojjam, 2023
Authors: Getnet Melaku Tadele , Afenigus Abebe Dilie , Gete Menberu , Emrie Ambaw Abebaw , Tsegaye Dejen
Published: November 2024

Background

Acute exacerbation of chronic obstructive pulmonary disease (COPD) poses a significant public health challenge globally, resulting in considerable health and economic burden. To date, there has been insufficient research in Ethiopia regarding poor treatment outcomes associated with these acute exacerbations.

Objective

This study aims to assess the poor treatment outcomes of acute exacerbations of chronic obstructive pulmonary disease and identify the associated factors among admitted patients in East Gojjam in 2023.

Design

An institutional-based cross-sectional study design was employed.

Methods

The institutional-based cross-sectional study was conducted from 7 April 2023 to 7 May 2023, involving 384 participants selected through simple random sampling. Data were extracted from patient charts and registers. Data entry was performed using EpiData, and the analysis was conducted using IBM SPSS Statistics version 26 software. Binary logistic regression analysis was used to identify the association between dependent and independent variables. Variables with a p-value of <0.25 in the bivariable logistic regression analysis were considered candidates for multivariable logistic regression. Variables with a p-value of <0.05 were considered statistically significant.

Results

Out of a total of 346 patients, 99 (28.6%) (95% CI, 23.9–33.3) developed poor treatment outcomes following exacerbations of chronic obstructive pulmonary diseases. Poor treatment outcomes were significantly associated with the following variables: age 65 or older (AOR = 3.9; 95% CI: 1.57–9.71), presence of comorbidities (AOR = 2.6; 95% CI: 1.287–5.20), a hospital stay longer than 7 days (AOR = 3.9; 95% CI: 1.97–7.70), and low oxygen saturation (<88%) (AOR = 9.0; 95% CI: 4.43–18.34).

Conclusion

Approximately one-third of the patients treated for acute exacerbations of chronic obstructive pulmonary disease at the Debre Markos Comprehensive Specialized Hospital experienced poor treatment outcomes. There is a significant association between poor treatment outcomes of acute exacerbation of chronic obstructive pulmonary disease and age ≥ 65 years, having comorbidities, prolonged hospital stay, and low oxygen saturation.
Unveiling the efficacy of paroxetine and gabapentin in ulcerative colitis patients in remission with co-existing IBS-like symptoms: a single-blinded randomized clinical trial
Authors: Safaei Farahnaz , Shahrokh Shabnam , Naderi Nosratollah , Rastegar Reyhaneh , Shamsi Alireza
Published: November 2024

Introduction

This clinical trial is designed to explore the efficacy of paroxetine and gabapentin in alleviating functional gastrointestinal symptoms, anxiety, depression, and quality of life in patients with ulcerative colitis during the remission stage.

Methods

The study enrolled 97 patients with ulcerative colitis in remission who had reported functional gastrointestinal symptoms. Patients were measured in terms of quality of life, anxiety, depression, and IBS severity. One group received paroxetine at a dosage of 20 mg/day, and the other group received gabapentin at a dosage of 100 mg/day in the first month and 300 mg/day in the second and third months. The patients were followed up for 3 months.

Results

Anxiety (p < 0.001), depression (p = 0.012), and severity score levels (p = 0.045) among patients in the paroxetine group were significantly lower compared to the gabapentin group following the intervention. Paired evaluation in each treatment group revealed a significant reduction in the paroxetine group, while changes in the gabapentin group were not significant. Quality-of-life scores among patients in the paroxetine group were significantly higher compared to the gabapentin group following the intervention (p < 0.001).

Conclusion

The rate of improvement in gastrointestinal functional symptoms, anxiety, depression, and quality of life is significantly superior with paroxetine compared to gabapentin.

Clinical trial registration

https://irct.behdasht.gov.ir/trial/69397, identifier RCT20220417054557N1.
The impact of COVID-19 on women’s reproductive system
Authors: Dong Shixiang , Liu Xia , Wang Yankui
Published: November 2024

The coronavirus disease 2019 (COVID-19) pandemic has been a major global focus since 2019. However, drug development and vaccination have been unable to stop the rise in the number of COVID-19 infections. As a result, almost everyone has been infected with COVID-19. As the COVID-19 pandemic nears its end, it is important to explore whether contracting COVID-19 has any irreversible effects on the female reproductive system. This article aims to review the effects of COVID-19 on the female ovary and reproductive system and examine whether these effects are permanent. In conclusion, we can state that COVID-19 has not caused any long-lasting effects on the reproductive health of most women, with the exception of a few cases where premature ovarian failure has been observed. These temporary effects, such as menstrual disturbances and temporary fertility loss, tend to diminish and eventually disappear over time.
Impact of the COVID-19 pandemic on surgical education and training programs in Latin America: a systematic review
Authors: Loza Hernandez Felipe , Ochoa Lantigua Pamela , Puga Rosero Vanesa , Jara Jimenez Sebastian , Carrera Cajamarca Mateo , Leon-Rojas Jose E.
Published: November 2024

Background

The COVID-19 pandemic posed challenges to surgical training, demanding a balance between theoretical and practical knowledge, especially in Latin American countries. Therefore, our aim was to characterize the challenges faced by surgical education in these countries.

Methods

A systematic search was conducted on PubMed, Scopus, and the Virtual Health Library on March 23, 2022, yielding 2,838 articles. Articles were filtered by two independent reviewers focusing on the effect of the pandemic in surgical education.

Results

A total of 31 articles were selected; 54.83% of surgical programs reported a reduction in surgical involvement by trainees. First-year residents were the most affected, with some surgical residency programs forced to shift their residents to take care of COVID-19 patients; additionally, in 67.74% of cases, online courses and virtual simulation was implemented. Most of the residents had a positive opinion regarding virtual lectures but considered that their surgical skills were affected.

Conclusion

The development of surgical skills was hindered by changes in surgery prioritization, techniques, and a decrease in caseload. The pandemic also caused a reliance on virtual formats for education and patient care. This shift created irregularities in training but increased opportunities for alternate activities.