bluuebunny/crossref_metadata_2025 huggingface dataset:
“Mission of Serving the Homeland”: Review of the Monograph “At the Crossroads of Times and Destinies”
Authors: Ivanova Tatiana
Published: February 2023

The article analyzes a new monograph about Moscow Pedagogical State University, which celebrated its 150th anniversary in 2022. The authors state the uniqueness of this university, which initiated higher education for women in Russia, became the first pedagogical university in the USSR, the flagship of pedagogical science development and alma mater for prominent representatives of national science and culture. The creative goal set by the team of authors in the book is to compose a collective biography of the University as a social institution and as a living academic community, examining its history at several levels (sociopolitical, discursive, institutional, material, sociocultural and spatial) has been quite successfully realized. The fundamentality of the analyzed sources and literature, the thoroughness of the chronologically problematic method of presentation, the multilateral coverage of the history of the university make it possible to refer the new monograph to the best examples of university studies in our country.
Modeling of spontaneous emission in presence of cylindrical nanoobjects: the scattering matrix approach
Authors:   Submicron Heterostructures for Microelectronics Research and Engineering Center of the Russian Academy of Science, Nikolaev V.V. , Girshova E.I. ,   Submicron Heterostructures for Microelectronics Research and Engineering Center of the Russian Academy of Science, Kaliteevski M.A. ,   ITMO University
Published: February 2023

We propose a method of analysis of spontaneous emission of a quantum emitter (an atom, a luminescence center, a quantum dot) inside or in vicinity of a cylinder. At the focus of our method are analytical expressions for the scattering matrix of the cylindrical nanoobject. We propose the approach to electromagnetic field quantization based of eigenvalues and eigenvectors of the scattering matrix. The method is applicable for calculation and analysis of spontaneous emission rates and angular dependences of radiation for a set of different systems: semiconductor nanowires with quantum dots, plasmonic nanowires, cylindrical hollows in dielectrics and metals. Relative simplicity of the method allows obtaining analytical and semi-analytical expressions for both cases of radiation into external medium and into guided modes.
Destrukcyjna siła resentymentu – Byk Szczepana Twardocha
Authors: Dąbrowska Dorota
Published: February 2023

Artykuł stanowi próbę analizy i interpretacji dramatu Byk Szczepana Twardocha oraz jego inscenizacji w reżyserii Roberta Talarczyka oraz Szczepana Twardocha (Teatr Studio, 2022). Zaprezentowana w artykule perspektywa badawcza jest skoncentrowana na refleksji nad ujawniającym się w utworze wątkiem śląskiej tożsamości oraz jego zależnością wobec problematyki resentymentu. Autorka artykułu odwołuje się do rozumienia tej kategorii zawartej w eseistyce Ewy Thomspon, a zatem do namysłu nad dwojakiego rodzaju rolami, przyjmowanymi przez członków społeczeństw krajów postkolonialnych. Analiza tekstu Twardocha w tej perspektywie pozwala na refleksję nad przenikaniem się wątków narodowych, klasowych i psychologicznych.
HETEROSIS AND INBREEDING DEPRESSION IN GRAIN SORGHUM HYBRIDS
Authors: SANTOS CRISLENE VIEIRA DOS , MENEZES CICERO BESERRA DE , SILVA KARLA JORGE DA , TUMA E SILVA CELSO HENRIQUE , REIS IASMIN MARRONY DAMASCENO , MIRANTE PAULA SILVA , TARDIN FLÁVIO DESSAUNE , BORÉM ALUÍSIO
Published: February 2023

This study aimed to estimate the heterosis, heterobeltiosis, and inbreeding depression in grain sorghum hybrids. Twenty-five hybrids were evaluated in two seasons. The evaluated traits were days to flowering (FL), plant height (PH), grain yield (GY), and thousand grains mass (M1000). The contrast tested were F1 hybrids vs. check cultivars, F1 hybrids vs. parental lines, and F1 hybrids vs. F2 hybrids. The hybrids 1167048, 1099044, 1170017, and 1169054 had a five-day less flowering time than their parental lines. The hybrid 1170017 had a high grain yield (6.23 t ha-1) with 43.55% of heterobeltiosis. The diversity between lines was narrow. However, hybrids with higher grain yield, heterosis, and heterobeltiosis showed higher genetic distances from their parental lines. The inbreeding depression between F1 vs. F2 was 30%, indicating that using F1 hybrids seeds is worthwhile.
Nowe technologie na rynku nieruchomości – w poszukiwaniu zrównoważonego rozwoju
Authors: Bartkowiak Piotr , Górska Anna , Koszel Maciej , Mazurczak Anna , Strączkowski Łukasz , Kinelski Grzegorz
Published: February 2023

Monografia podejmuje aktualną i istotną tematykę wykorzystania nowoczesnych technologii, w tym innowacyjnych produktów technologicznych i biznesowych w działalności podmiotów aktywnych na rynku nieruchomości mieszkaniowych, głównie na rynku pierwotnym. Jest to słabo rozpoznany do tej pory obszar badawczy wykorzystujący innowacyjne technologie z grupy PropTech, które oddziałują na zrównoważony rozwój lokalnych rynków mieszkaniowych w Polsce, a także funkcjonowanie miast i aglomeracji (w szerszym zakresie). Autorów interesuje oddziaływanie nowoczesnych technologii na społeczeństwo, w tym społeczności lokalne, środowisko naturalne, ład korporacyjny, gospodarkę lokalną, w tym rynek pracy. Zasadniczym celem monografii jest przedstawienie teoretycznych i praktycznych aspektów PropTech w odniesieniu do działalności deweloperów mieszkaniowych na lokalnym rynku nieruchomości. Autorzy dokonali krytycznego przeglądu literatury oraz przeprowadzili badania własne wśród przedsiębiorstw deweloperskich na wybranym lokalnym (poznańskim) rynku mieszkaniowym.
The effects of low-dose sorafenib on epithelial-mesenchymal transition and multidrug resistance markers in HepG2 cell line
Authors: DÖNMEZ ÇAKIL Yaprak , AKBULUT Zeynep , DEMİREL Gamze , GÜLHAN Ranan , OZUNAL Zeynep
Published: February 2023

Objectives: Sorafenib is an orally administered tyrosine kinase inhibitor in hepatocellular cancer. Low sorafenib concentrations are attained during pharmacotherapy due to pharmacokinetic profile and patient inadherence. Resistance to treatment is a limitation to improving survival. Underlying mechanisms include epithelial-mesenchymal transition. The aim of the study was to evaluate epithelial-mesenchymal transition and multidrug resistance-related parameters in HepG2 cells following low-dose and short-term sorafenib treatment.
Methods: Epithelial-mesenchymal transition and multidrug resistance-related markers were examined by quantitative PCR, flow cytometry, and confocal laser scanning microscopy.
Results: An increase in epithelial marker E-cadherin and downregulation of mesenchymal markers Vimentin and Snail1 were detected by gene expression analysis. While P-glycoprotein expression increased, multidrug resistance protein 1, and breast cancer resistance protein mRNA levels did not alter after sorafenib treatment. The accumulation of the ABC transporter substrate rhodamine 123 in the cells increased following the treatment, corresponding to a less efficient efflux of rhodamine 123 and a possible effect on other transporters and mechanisms.
Conclusions: The results indicate a protective effect of sorafenib against epithelial-mesenchymal transition and upregulation in P-glycoprotein expression, which is, however, not sufficient to cause less intracellular rhodamine 123 accumulation. The effects of low-dose and short-term sorafenib on epithelial-mesenchymal transition and multidrug resistance-related markers might contribute to enlightening new treatment strategies in hepatocellular cancer.
Edukasi fesyen muslim: Upaya meningkatkan kreativitas melalui hijab masker di tengah pandemi
Authors: Fadlullah Hana Kharis , Miranti Ajeng Rizki , Hasanah Uswatun
Published: February 2023

This Community Service activity aims to educate the public about the opportunities for hijab masks amid a pandemic. As Participatory Action Research, this community service was carried out through online seminars, online discussions, and online assistance through Whatsapp groups. This activity has been conducted in Kudus regency. The participants are the millennial community who is the potential to develop hijab masks for their economic recovery. This service provided a positive response for the community so that they are more aware of efforts to be more creative amid a pandemic. They were equipped with education from well-known hijab activists in providing understanding to create attractive fashion designs and have branding. This service recommendation can provide direct follow-up assistance through the blended method to make it more effective.

(Kegiatan Pengabdian Kepada Masyarakat ini bertujuan untuk memberikan edukasi kepada masyarakat tentang peluang hijab masker di tengah pandemi. Metode PAR ini dilaksanakan melalui seminar online, diskusi online dan pendampingan online melalui Whatsapp grup. Kegiatan ini dilaksanakan di kota Kudus dengan peserta masyarakat milenial yang memiliki potensi mengembangkan hijab masker untuk pemulihan ekonomi mereka. Hasil pengabdian ini memberikan respon posisif bagi masyarkat sehingga lebih sadar akan upaya untuk lebih kreatif di tengah pandemi. Mereka dibekali edukasi dari pegiat hijab ternama untuk memberikan pemahaman untuk membuat desain fesyen yang menarik dan memiliki branding. Rekomendasi pengabdian ini dapat memberikan pendampingan lanjutan secara langsung melalui metode blended agar lebih efektif.)
Pemanfaatan potensi bambu sebagai pemberdayaan ekonomi masyarakat berbasis Asset Based Community Development di Desa Bringsang Giligenting
Authors: Yuli Firdaus Nabila , Usriyah Nasidatul , Muqoddas Najwa , Farisya Nurul Huda , Nathifah Orisa Sativa , Syah Muhammad Reza Ali , Mujiburrohman Mujiburrohman , Fauzi Noer Moh Bahrul , Astuti Ria
Published: February 2023

Bamboo is a very useful plant for the community's economic life. Traditionally, generally, bamboo can be used for various purposes, such as household utensils, handicrafts, and foodstuffs. Currently, the potential in the form of bamboo is abundant but still needs to be utilized by the community in Bringsang Village. Giligenting District, Sumenep Regency. This service-based research aims to carry out training and mentoring programs for the community regarding the utilization of bamboo assets as souvenirs with high economic value. The approach in this study uses the Aset Based Community Development (ABCD) method, which focuses on local assets, potential and domestic strengths. This research starts with production training, product branding training, and online and offline Marketing Training. This service-based research succeeded in creating souvenirs from bamboo in the form of key chains, decorative lights, figures, food plates, and drinking bottles with the branding "BAMBRING" Souvenirs typical of Bringsang. Through the role of Karang Taruna as a local group, this production process has the full support of the village government and other stakeholders. This product can be an alternative livelihood for the local community so that it can create products that have an impact on increasing mutual welfare.(Bambu merupakan tanaman yang sangat bermanfaat bagi kehidupan ekonomi masyarakat. Secara tradisional, umumnya bambu dapat digunakan untuk berbagai keperluan seperti peralatan rumah tangga, kerajinan tangan, dan bahan makanan. Saat ini, Potensi berupa bambu jumlahnya sangat melimpah namun masih belum dimanfaatkan oleh masyarakat di Desa Bringsang. Kec. Giligenting, Kab. Sumenep. Penelitian berbasis pengabdian ini bertujuan untuk melaksanakan program pelatihan dan pendampingan kepada masyarakat mengenai pemanfaatan aset bambu menjadi kerajinan souvenir bernilai ekonomi tinggi. Pendekatan pada penelitian ini menggunakan metode Aset Based Community Development (ABCD) yang berfokus pada aset, potensi dan kekuatan lokal domestik. Penelitian ini dimulai dari pelatihan produksi, pelatihan branding produk, dan Pelatihan Pemasaran secara online dan offline. Penelitian berbasis pengabdian ini berhasil menciptakan souvenir dari bambu berupa gantungan kunci, lampu hias, figura, tepak makan, dan botol minum dengan branding “BAMBRING” Souvenir khas Bringsang. Melalui peran Karang Taruna sebagai local group, proses produksi ini mendapat dukungan penuh dari pemerintah desa dan stakeholders lainnya. Produk ini dapat menjadi alternatif mata pencaharian masyarakat setempat sehingga dapat menciptakan produktifitas yang berdampak pada peningkatan kesejahteraan bersama).
Lithological characteristics of the pre-Greben' regional unconformity of the Sizimcelebeyshor Creek of the Chernov Uplift
Authors: Danshchikova I. , Ulnyrov I. , Maydl T.
Published: February 2023

A lithological description of natural outcrops of Upper Silurian rocks in the section of the Sizimcelebeyshor creek of the Chernov uplift has been presented. Based on the results of the studies, the sedimentation gap at the end of Gerd'yu superhorizon is characterized. We consider breccias and interlayers of red-green plastic eluvial clays associated with the unconformity as occurrences of the Silurian paleocarst. This factor should be taken into account in the local forecast of zones with improved reservoir properties for carbonate rocks. The conducted studies allow significantly replenishing the sedimentological and chronostratigraphic characteristics of this area of work, which in the future can contribute to solving problems of regional correlation, paleofacial reconstructions and optimization of geological exploration.
Preliminary mineralogical assessment of the Kuznetskaya coal preparation plant wastes
Authors: Chikisheva T. , Komarova A. , Prokopyev S. , Prokopyev E.
Published: February 2023

A preliminary assessment by the optical-mineralogical analysis can often be sufficient to solve production tasks, to study the raw composition, and to choose a processing method at the initial stages of technological researches. Such an assessment will also help to determine the vector of further studies. The material for the primary mineralogical assessment was a waste sample from the Kuznetskaya Central Processing Plant. We used the method of optical-mineralogical analysis during the mineralogical study. Factory wastes are related to the technogenic mineral raw of the first group. We have shown that it is necessary to involve coal mining wastes in the comprehensive recycling with the obligatory mineralogical and technological assessment to determine methods of preparing raw for processing and technology of its enrichment. Our conclusion is that gravity processing methods can be used for the primary concentration of coal from tailings.
Apresentação do Dossiê Patrimônio Alimentar e Agrobiodiversidade
Authors: Fachini Cristina , Basso Rafaela
Published: February 2023

Esse editorial discorre sobre os sete artigos que integram o Dossiê sobre Patrimonio Alimentar e Agrobiodiversidade que compõe a edição contínua do volume 17 dessa Revista.
Hepatocellular carcinoma after treatment of hepatitis C with direct-acting antivirals: a critical re-appraisal
Authors: Kouroumalis Elias , Tsomidis Ioannis , Voumvouraki Argyro
Published: February 2023

Soon after introducing direct-acting antiviral agents (DAAs) for chronic hepatitis C treatment, there began a debate over the possibility of hepatocellular carcinoma (HCC) after viral clearance. Although several reports suggested that the question has been answered negatively, other reports suggested the opposite. The present review presents data in favor and against the null hypothesis and analyzes the scientific background of the possible participation of DAAs in HCC development. The reasons for the discrepancy among studies are presented. These include heterogeneity of patient selection, the nature of the studies, and the tumors themselves are responsible for varying results. Exogenous factors like alcohol consumption or metabolic syndrome confound these findings and suggest the need for statistical adjustments. The need for careful attention to the statistical details is exemplified, and the significant points of almost universal agreements are identified. The conclusion is that the definitive study is impossible for ethical and scientific reasons, and the physician should not ignore even simple personal observations and screening of all patients with extensive fibrosis in HCC, irrespective of sustained virologic response, until a robust, reliable prognostic model can be invented.
Analysis of supply chain management system using lean six sigma: Balanced scoredcard parameters approach
Authors: Prasetyo Wahyu Eko
Published: February 2023

The potential development of the beauty product industry in Indonesia is considered very attractive. The beauty products industry and trade in Indonesia is projected to increase by USD 7.5 billion with a growth of 6.5% annually for the next five years. The huge potential in the cosmetics retail business is considered to trigger the emergence of competition, especially in the supply chain system which has implications for product affordability to consumers. So that this becomes an interesting condition for research to be carried out as well as efforts to provide certain improvement treatments so that there is an improvement in the flow of the supply system in the object company. In this study, 3 layers of the research process will be carried out, namely observing and describing the existing supply chain system in the research object company, improving and treating the supply chain system using a lean six sigma model with stages of define, measure, analyze, improve, control (DMAIC), and make observations as well as measure the results of improvement using 4 (four) balanced scoredcard performance indicators. Data mining using observation methods, interviews, scoring key performance indicators in each perspective, and study of company operational administration data. Based on the results of study, the supply system based on 4 balanced scoredcard indicators still has shortcomings, namely in the value of debt-to-equity ratio, quantity and customer quality, internal business organization, and personnel accountability. The recommendation is that this study can have an improving effect on the object company and also be a reference for other companies specifically with the same segmentation.
The effect of Covid-19 pandemic on regional financial performance in Indonesia: Meta-analysis
Authors: Altin Darus , Vebtasvili Vebtasvili , Eprianto Idel
Published: February 2023

This meta-analysis aims to analyze the impact of the Covid-19 pandemic on regional financial performance in Indonesia. The research method used by reviewing, summarizing data and analyzing some research results that have been published on google scholar and the ministry of education and culture's Sinta page with the keywords Covid-19 and regional financial performance. From the 45 articles collected, 18 articles were selected for further analysis according to this research topic. This type of research is a meta-analysis research where the steps taken include: data collection, coding, calculation of improving problem-solving ability and identifying the presence or absence of average differences, and drawing conclusions. Our findings show that Covid-19 pandemic in Indonesia has been shown to have an impact on regional financial performance in Indonesia. Although there are several provinces in Indonesia, it does not have an impact on its financial performance. Financial performance is measured from the regional financial independence, the ratio of local tax to paid allowance, the ratio of operational solvency of local governments, the ratio of pad effectiveness and capital expenditure. There is a budget policy from the central government to focus on handling the Covid-19 pandemic so that it impacts regional financial performance. Future research contributions are expected to be an opportunity for the development of research methodologies, especially in the aspect of data collection through questionnaires and data analysis techniques using PLS (Partial Least Square), Data Panel Analysis and Symbolic Interaction methods.
A Study on Code Smell Detection with Refactoring Tools in Object Oriented Languages
Authors:   Research Scholar, Bharathiar University, Coimbatore,Tamil Nadu, India, Felix S.James Benedict , Vinod Viji ,   Professor & Head, Department of Computer Applications,Dr.MGR Educational and Research Institute University,Chennai , India
Published: February 2023

A code smell is an indication in the source code that hypothetically indicates a design problem in the equivalent software. The Code smells are certain code lines which makes problems in source code. It also means that code lines are bad design shape or any code made by bad coding practices. Code smells are structural characteristics of software that may indicates a code or drawing problem that makes software hard to evolve and maintain, and may trigger refactoring of code. In this paper, we proposed some success issues for smell detection tools which can assistance to develop the user experience and therefore the acceptance of such tools. The process of detecting and removing code smells with refactoring can be overwhelming.
Detection of Node Activity and Selfish & Malicious Behavioral Patterns using Watchdog � Chord Monitoring
Authors:   PG Scholar, Dept. of CSE,Archana Institute of Technology., MS M.Vanishree , MR R.Arun ,   Assistant Professor,Dept. of ECE,Sri Venkateswaraa College of Technology
Published: February 2023

Mobile ad-hoc networks(MANETs) assume that mobile nodes voluntary cooperate in order to work properly. This cooperation is a cost-intensive activity and some nodes can refuse to cooperate, leading to a selfish node behaviour. Thus, the overall network performance could be seriously affected. The use of watchdogs is a well-known mechanism to detect selfish nodes. However, the detection process performed by watchdogs can fail, generating false positives and false negatives that can induce to wrong operations. Moreover, relying on local watchdogs alone can lead to poor performance when detecting selfish nodes, in term of precision and speed. This is especially important on networks with sporadic contacts, such as delay tolerant networks (DTNs), where sometimes watchdogs lack of enough time or information to detect the selfish nodes. Thus, We apply chord algorithm to identify behavior pattern of one shelf by two neighborhood nodes and themselves. Servers will finally categories nature of node.
ПРИЛИВНОЕ УСКОРЕНИЕ В СФЕРИЧЕСКИ-СИММЕТРИЧНОЙ МЕТРИКЕ НА ОСНОВЕ МОДИФИЦИРОВАННОГО УРАВНЕНИЯ ДЕВИАЦИИ ГЕОДЕЗИЧЕСКИХ
Authors:   Лаборатория теоретической физики им. А. А. Фридмана, Расулова Анна ,   ИНОЗ РАН - СПбФИЦ РАН
Published: February 2023

В данной статье проводится анализ модифицированного уравнения девиации геодезических линий в искривлённом пространстве-времени Шварцшильда. Основным отличием обобщённого уравнения девиации от классического является то, что тестовые частицы могут находиться на любом расстоянии друг от друга, т. е. геодезические не являются бесконечно близкими. Для простоты решения было принято, что одна частица имеет только радиальную компоненту 4-скорости, а вторая - только круговую. В результате анализа было выявлено, что в зависимости от расстояния и скорости тестовых частиц знак приливных сил может меняться.
ИССЛЕДОВАНИЕ УЗКИХ ПОТОКОВ СУБАВРОРАЛЬНЫХ ИОННЫХ ДРЕЙФОВ ВО ВРЕМЯ ГЕОМАГНИТНОЙ АКТИВНОСТИ НА ОСНОВЕ СПУТНИКОВЫХ ДАННЫХ
Authors:   ИКИ РАН, Синевич Александр , Чернышов Александр , Чугунин Дмитрий
Published: February 2023

Субавроральная область ионосферы на сегодняшний день является актуальным предметом исследования, так как многие явления, происходящие в ней, изучены не до конца. Одно из таких явлений - поляризационный джет. Исследование параметров поляризационного джета до настоящего времени проводилось с помощью измерений наземных станций и спутниковых приборов с максимальной частотой опроса 1-5 Гц. Учитывая, что поляризационный джет обычно имеет небольшие пространственные размеры, для исследования его мелкомасштабной структуры необходимы измерения со значительно большей частотой опроса. В настоящей работе представлены результаты измерений параметров плазмы внутри поляризационного джета с номинальной частотой опроса 1 кГц, проведённых установленной на спутнике NorSat-1 системой зондов Ленгмюра. В результате исследования установлено наличие неоднородностей температуры и концентрации электронов внутри поляризационного джета с пространственными размерами в десятки-сотни метров. Подтверждены известные ранее особенности развития поляризационного джета, а также обнаружено, что с развитием геомагнитной активности распределение температуры электронов внутри него разделяется на два выраженных пика.
ИССЛЕДОВАНИЕ ВОЗМОЖНОСТИ ИЗУЧЕНИЯ ПОЛИГОНОВ ТВЁРДЫХ БЫТОВЫХ ОТХОДОВ С ПОМОЩЬЮ СПУТНИКОВЫХ ДАННЫХ ВЫСОКОГО РАЗРЕШЕНИЯ
Authors:   ИКИ РАН, Смолина Алина
Published: February 2023

Для получения более полной информации о пространственных масштабах и протекающих процессах на полигонах твёрдых бытовых отходов (ТБО) были проанализированы спутниковые изображения на примере полигонов ТБО «Кучино», «Торбеево» и «Тимохово» за 2016 и 2019 гг. Изучались изображения в видимом и инфракрасном диапазонах (Landsat-8, OLI, TIRS; Sentinel-2A/B, MSI), а также радиолокационные данные (Sentinel-1A/B, SAR-C). Результаты косвенно свидетельствуют о наличии тепловых потоков, возникающих из-за складирования отходов.
СРАВНЕНИЕ МОРФОМЕТРИЧЕСКИХ ХАРАКТЕРИСТИК ОЗЁР ДЛЯ РАЗЛИЧНЫХ ВОДНЫХ ИНДЕКСОВ
Authors:   ИНОЗ РАН – СПбФИЦ РАН, Шмакова Виктория
Published: February 2023

Данные дистанционного зондирования позволяют получить информацию о пространственно-временных параметрах поверхности Земли, в том числе и о водных объектах. Основная задача работы состоит в отделении водной поверхности на спутниковых снимках и анализе точности полученных результатов. В рамках настоящей работы была составлена программа для расчёта водных индексов на основе платформы Google Earth Engine для коллекции спутниковых снимков Sentinel-2, Landsat-8 и MODIS. В результате анализа полученных изображений были выявлены различия между водными масками, рассчитанными для разных водных индексов на основе снимков с различных спутников.
Abortion-Related Laws and Concurrent Patterns in Abortion Incidence in Indiana, 2010–2019
Authors: Moseson Heidi , Smith Mikaela H. , Chakraborty Payal , Gyuras Hillary J. , Foster Abigail , Bessett Danielle , Wilkinson Tracey A. , Norris Alison H.
Published: February 2023

Objectives. To analyze abortion incidence in Indiana concurrent with changes in abortion-related laws.

Methods. Using publicly available data, we created a timeline of abortion-related laws in Indiana, calculated abortion rates by geography, and described changes in abortion occurrence coincident with changes in abortion-related laws between 2010 and 2019.

Results. Between 2010 and 2019, Indiana’s legislature passed 14 abortion-restricting laws, and 4 of 10 abortion-providing clinics closed. The Indiana abortion rate decreased from 7.8 abortions per 1000 women aged 15 to 44 years in 2010 to 5.9 in 2019. At all time points, the abortion rate was 58% to 71% of the Midwestern rate and 48% to 55% of the national rate. By 2019, nearly 1 in 3 (29%) Indiana residents who obtained abortion care did so outside the state.

Conclusions. Access to abortion in Indiana over the past decade was low, required increases in interstate travel to obtain care, and co-occurred with the passage of numerous abortion restrictions.

Public Health Implications. These findings preview unequal abortion access and increases in interstate travel as state-level restrictions and bans go into effect across the country. (Am J Public Health. 2023;113(4):429–437. https://doi.org/10.2105/AJPH.2022.307196 )
Posttraumatic Patellar Osteomyelitis due to Raoultella ornithinolytica
Authors: Graham George D. , Jeray Kyle J.
Published: February 2023

Case:

A 59-year-old woman sustained a comminuted patellar fracture after a fall from standing. The injury was treated with open reduction and internal fixation 7 days from initial injury. Seven weeks postoperatively, she developed a swollen, painful, and draining knee. Workup demonstrated Raoultella ornithinolytica. She underwent surgical debridement and antibiotic treatment.

Conclusion:

This is an unusual presentation of patellar osteomyelitis with R. ornithinolytica. Early identification, treatment with appropriate antimicrobial therapy, and consideration of surgical debridement are important in patients presenting with pain, swelling, and erythema after surgery.
Pectoralis Major Muscle Belly Rupture in a 17-Year-Old Female Softball Player
Authors: Kuechly Henry A , Figueras Jorge H , Figueras Jorge , Gordon Garrett , Johnson Brian M , West Justin W , Grawe Brian M
Published: February 2023

Case:

We report the case of a healthy 17-year-old female softball player with a subacute full-thickness intramuscular tear of the pectoralis major (PM) muscle. A successful muscle repair was obtained using a modified Kessler technique.

Conclusions:

Despite initially being a rare injury pattern, the incidence of PM muscle rupture is likely to increase as interest in sports and weight training increases, and although this injury pattern is more common in men, it is becoming more common in women as well. Furthermore, this case presentation provides support for operative treatment of intramuscular ruptures of the PM muscle.
Epidemiology of Hand and Wrist Injuries in Outdoor Recreational Activities
Authors: Weis Jamie L. , Matullo Kristofer S.
Published: February 2023

Introduction:

With participation in outdoor and remote activities rising, it is essential for wilderness medicine clinicians to be aware of the hand, wrist, and forearm injuries that commonly occur. From mountain biking to rock climbing to dog walking, hand and wrist injuries are ubiquitous, and knowledge of them can improve preparedness.

Methods:

This was a retrospective study that evaluated hand, wrist, and forearm injuries, sustained during recreational outdoor activities, that then presented to orthopaedics. Data were recorded over the course of 1 calendar year for activity, body part, injury type, sex, age, and the need for surgery. This was then analyzed to highlight trends.

Results:

Of 436 hand, wrist, and forearm injuries, the wrist was the most frequently injured upper extremity body part with 253 injuries. The most common type of injury was fracture with 336, and of these fractures, 170 were of the distal radius. Biking, skateboarding, and dog walking were the most common causes of injury, and the most frequently injured patients were young men and older women.

Conclusion:

This study underscores the importance of clinician preparation for evaluation and management of hand, wrist, and forearm injuries, including distal radius fractures. It also highlights the importance of recognizing patients at risk for osteoporosis. Having knowledge of the leading injuries, most common mechanisms, and most at-risk patients helps with clinician training, provider and kit preparedness, and participant education.
O impacto da pandemia da COVID-19 nos exames de rastreamento do câncer no Brasil: um estudo comparativo dos cânceres de mama, próstata e colo de útero
Authors: Oliveira Isabela , Mandel Manuela , Holtz Luciana , Santos André , Barbosa Marcus Vinícius , Carloni Marcelo , Clark Otávio Augusto
Published: February 2023

Objetivo: Analisar a influência da pandemia da COVID-19 na execução dos exames de rastreamento e diagnóstico dos cânceres de próstata, mama e colo uterino na população brasileira. Métodos: Estudo analítico transversal e quantitativo com levantamento do número desses exames realizados pelo SUS (Sistema Único de Saúde). Os dados foram extraídos do Datasus nos períodos de pré-pandemia (março/2019 a fevereiro/2020) e pandemia (março/2020 a fevereiro/2021). Foram extraídos os números de exames realizados mês a mês e comparados os períodos pré-pandemia com o de pandemia. Foi realizada uma análise estatística descritiva, e as médias mensais de exames realizados nos dois períodos foram comparadas usando o teste t de Student. Resultados: Na comparação entre os períodos pré-pandemia e de pandemia, houve diminuição de média de 45,2% no número de exames citopatológicos, (194.978 exames por mês a menos; p < 0,00001), de 44,4% nos exames de mamografia (142.015 mamografias a menos por mês; p < 0,00001) e de 24,4% nos exames de antígeno prostático específico (PSA) (148.815 exames a menos por mês; p = 0,0012). Conclusão: A influência da pandemia gerou uma diminuição considerável no número de exames de rastreamento, mamografia, dosagem de PSA e citopatológico, o que deverá se traduzir em aumento nos casos de doença avançada, com graves consequências negativas para os pacientes e para o sistema de saúde.
Approximating local solution of the IVPs of nonlinear first order ordinary integrodifferential equations
Authors: Dhage Janhavi B. , Dhage Bapurao C.
Published: February 2023

In this paper, we prove a couple of approximation results for local existence and uniqueness of the solution of a IVP of nonlinear first order ordinary hybrid integrodifferential equations by using the Dhage monotone iteration method based on a hybrid fixed point theorem of Dhage (2022) and Dhage et al. (2022). An approximation result for the Ulam-Hyers stability of the local solution of the considered hybrid differential equation is also established. Our main abstract results are also illustrated with a couple of numerical examples. 2010 MSC: 47H10, 34A12, 34A34.
Novel Fuzzy Entropy Based Leaky Shufflenet Content Based Video Retrival System
Authors: R Kavitha A , Simon Michael Dinesh , Sumathy G
Published: February 2023

Developing Content-Based Video Retrieval (CBVR) for large-scale videos is a major challenge due to the enormous growth of video content on the internet. One of the major downfalls associated with CBVR is high search response time and low accuracy. In this paper, a Novel Fuzzy entropy based Leaky ShuffleNet CBVR system has been proposed to reduce the search response time and for high accuracy. The proposed system has three major phases i) Data Processing, ii) Feature Extraction and iii) Feature selection and iv) Similarity search. Initially, the video is processed using Apache storm to convert video into keyframes. Consequently, facial landmarks, head pose, and eye gaze, edges are extracted using various feature extraction techniques. The most relevant features are selected in the feature selection phase by using the Fuzzy entropy measure. Finally, based on the selected features Leaky ShuffleNet retrieve the relevant videos based on the user query. Experiments were performed on two different datasets such as Hollywood2 and UCF50 in three different setups (Single Node, Vertical Scaling, Horizontal Scaling). Several metrics were analyzed to measure the effectiveness of the suggested strategy, including recall, specificity, accuracy, precision, and the F-measure. According to experimental results, the proposed system has a search reaction time of 0.75 seconds, which is lower than the existing methods. The proposed method improves the overall accuracy by 1.2%, 2.5%, and 3.2% better than the existing ECBVR-ACNN, FALKON, and EE-CBVR respectively.
Comparative physiology and transcriptome analysis to identify the important coding and non-coding RNAs imparting tolerance to salinity stress in alfalfa (Medicago sativa L.)
Authors: Yu Rugang , Li Zhengyan , Rong Mengru , Yang Gaimei , Xu Xian , Wang Guoliang , Xu Zhiming , Du Xueling , Zhang Qiting
Published: February 2023

Background: Salinity is among the most harmful agents that impacts alfalfa’s productivity. However, little is known regarding how salinity tolerance trait is regulated by lncRNAs in alfalfa. To evaluate the mRNAs and lncRNAs associated with tolerance to salinity stress in alfalfa, the root transcriptomics of two alfalfa cultivars differing in salinity tolerance, i.e., GN5 (tolerant to salinity) and GN3 (sensitive to salinity), were investigated under 0 and 150 mM NaCl treatments.
Results: A total of 172,986 mRNAs and 117,677 lncRNAs were identified, of which 2288 mRNAs and 1466 lncRNAs were significantly differentially expressed in four comparisons (GN5-150 vs. GN5-0, GN3-150 vs. GN3-0, GN5-0 vs. GN3-0, and GN5-150 vs. GN3-150). Based on GO and KEGG pathway analysis, the expression levels of several osmotic and ionic stress-related genes, including HPCA1-LRR, PP2C60, PP2C71, CRK1, APX3, HXK2, BAG6, and ARF1, were higher in GN5 than in GN3. CNGC1 was significantly downregulated by NaCl treatment in GN5. The co-expressed network analysis indicated that TCONS_00113549, TCONS_00399794, TCONS_00297228, TCONS_00004647, TCONS_00033214 and TCONS_00285177 in alfalfa roots regulated 66 genes including the four genes mentioned above. Therefore, the above nine genes and six lncRNAs might contribute to the difference in salinity tolerance between GN5 and GN3.
Conclusions: We discovered a broad survey of mRNAs and lncRNAs associated with the difference of salinity tolerance between GN5 and GN3. These findings would be useful for further functional analysis as potential targets to improve resistance to salinity stress via genetic engineering.
Citrullinated and MMP-degraded vimentin is associated with chronic pulmonary diseases and genetic variants in PADI3/PADI4 and CFH in postmenopausal women: an observational study
Authors: Bager Cecilie Liv , Blair Joseph P. M. , Tang Man-Hung Eric , Mortensen Joachim Høg , Bay-Jensen Anne-Christine , Frederiksen Peder , Leeming Diana , Christiansen Claus , Karsdal Morten Asser
Published: February 2023

Background
Citrullinated vimentin has been linked to several chronic and autoimmune diseases, but how citrullinated vimentin is associated with disease prevalence and genetic variants in a clinical setting remains unknown. The aim of this study was to obtain a better understanding of the genetic variants and pathologies associated with citrullinated and MMP-degraded vimentin.
Methods
Patient Registry data, serum samples and genotypes were collected for a total of 4369 Danish post-menopausal women enrolled in the Prospective Epidemiologic and Risk Factor study (PERF) Circulating citrullinated and MMP-degraded vimentin (VICM) was quantified using -a well-established biomarker assay. Genome-wide association (GWAS) with serum levels of VICM and Phenome Wide Association (PheWAS) with the identified polymorphisms were performed.
Results
High levels of VICM was significantly associated with the prevalence of chronic pulmonary diseases and death from respiratory and cardiovascular diseases (CVD). GWAS identified 33 single nucleotide polymorphisms (SNPs) with a significant association to VICM. These variants were in the peptidylarginine deiminase 3/4 (PADI3/PADI4) and Complement Factor H (CFH)/ KCNT2 gene loci on chromosome 1.
Conclusion
Serum levels of VICM, a marker of citrullinated and MMP-degraded vimentin, were associated with chronic pulmonary diseases and genetic variance in PADI3/PADI4 and CFH/ KCNT2. This points to the potential for VICM to be used as an activity marker of both citrullination and inflammation identifying responders to targeted treatment and patients likely to experience disease progression.
Resonance assignments of the PUB domain of the RNF31 protein
Authors: Song Lanlan , Zhong Fumei , Zhang Jiahai , Tu Xiaoming
Published: February 2023

RNF31 is identified in human proteins and is involved in activities of the linear ubiquitin chain assembly complex (LUBAC) and cell growth. RNF31 plays an important role in LUBAC-mediated ubiquitination. Here, we report the backbone and side-chain resonance assignments of the PUB domain of RNF31 and study the backbone relaxation of the domain. These studies will contribute to further understanding of the structure and function relationship of the RNF31 protein.
CircAkt3 participates in bone cancer pain progression in rats by modulating MAPK signalling pathway
Authors: Chen Lvlv , Zhang Xiaoxia , Su Yuqi , Tang Tianying , Chen Hanwen , Alam Azeem , Kamath Priyanka , Chen Qian , Zhao Hailin , Zhang Yiwen
Published: February 2023

Background: Cancer-induced bone paincaused by advanced tumor bone metastasis remains a clinical challenge, and the underlying mechanisms of BCP remain unknown. This study aimed to screen the expression profile of circular RNAs in a BCP rat model and provide a new theoretical basis for the role of circular RNA in the occurrence and development of BCP.
Methods: We established a BCP rat model. The top four differentially expressed circRNAs (DECs) in the model were validated by agarose gel electrophoresis and Sanger sequencing between the BCP group and sham group. A circRNA-miRNA-mRNA network was constructed based on the interactions among circRNAs, microRNA (miRNA), and mRNA, which were predicted by TargetScan. mRNA and circRNA expression levels were detected by quantitative RT-PCR. In addition, Western Blot was performed to identify the protein levels of p-ERK, ERK, and Col8a1.
Results: CircRNA parent genes were mainly enriched in MAPK and neurodevelopmental signalling pathways. CircAkt3 and circMap4k1 were significantly up-regulated in the BCP group. CircaAkt3 may increase p-ERK expression by upregulating Col8a1, which may further activate the MAPK pathway.
Conclusions: The circAkt3 pathway may influence the development of bone cancer pain by activating the MAPK signaling pathway. This study provided important targets for the development of therapeutic strategy against BCP.
Intraradicular diameter, remnant dentin thickness, and endodontic post-to-dentin distanc: An investigation using CBCT and microscopy
Authors: Souza Júlio C. M. , Soares Catarina , Fernandes Valter , Carvalho Oscar , Silva Filipe , Özcan Mutlu , Henriques Bruno
Published: February 2023

The objective of this work was to measure the tooth root canals’ diameter, remnant dentin thickness, and the endodontic post-to-dentin distance after three types of root canal preparation. Thirty extracted human premolars were endodontically treated and groups of specimens were divided according to the cementation with two different endodontic post as follow: A) Fibio Fiberglass Post™, Anthogyr, France; B) multi-filament GFRC (Rebilda GT™, VOCO, Germany). Cone beam computed tomography (CBCT) and conventional x-ray analyses were performed before and after the endodontic post cementation. After cementation, specimens were cross-sectioned and inspected by optical microscopy and scanning electron microscopy at magnification from x30 up to x2000. The shape variation of the root canal preparation caused a decrease in the thickness of the remnant tooth tissues. CBCT and microscopic analyses also revealed a clear variation of resin-matrix cement around all the endodontic GFRC posts. A multi-filament GFRC post provided a distribution of filaments although the resin-matrix cement revealed a high volume among the filaments. An increase in thickness and volume of resin-matrix cement was noticed at the coronal third since the fitting was compromised due to anatomic variations and root canal preparation. Defects such macro-scale pores, cracks, and voids were also detected by microscopic analyses. The root canal preparation can promote a decrease in the thickness of the remnant tooth tissues that can increase the risks of clinical failures by fracture. The thickness and volume of resin-matrix cement varied around both GFRC posts. Additionally, that increased from the apex up to the coronal third due to the lack of fitting. Clinical significance: The root canal preparation of teeth is the first step the fitting of glass fiber-reinforced composite (GFRC) post. However, the tooth tissues must be preserved to maintain the mechanical integrity of the restored tooth. An adequate fitting of the GFRC post along the intracanal regions can promote a well-distribution of the resin-matrix cement volume that decreases the risks of defects such as voids and cracks.
The effect of triage training using the WebQuest method on the knowledge level of nursing students in patient triage
Authors: Saeedi Maryam , Panahi Marzieh
Published: February 2023

Background: In conventional educational programs, learners are passive during instruction and are rarely given the opportunity to think. One of the student-centered educational methods that causes deep learning in students is the WebQuest method. which can create an important transformation in learners. Considering the limited studies in this field, the present study was conducted with the aim of comparing the effectiveness of lecture and web quest methods on the knowledge of nursing students in patient triage at Saveh University of Medical Sciences.
Method: This research is an interventional and semi-experimental study. The present study was conducted in Saveh University of Medical Sciences between 2021 and 2022. The participants included Sixty-eight nursing students of the fifth semester who were randomly assigned to intervention and control groups. The control group was trained by the instructor and the intervention group was trained by the 6-step web quest method. The triage Knowledge questionnaire was taken as a pre-test and post-test. Then the scores were analyzed using the Wilcoxon, Mann-Whitney and independent t-tests.
Results: The average score of students' knowledge about triage in the control and intervention groups, before the intervention, did not have a statistically significant difference (P=0.89). But after the intervention, the average score of students' knowledge about triage in the control and intervention groups had a statistically significant difference (P<0.001).
Conclusion: The results of this research showed that teaching triage using the web quest method causes enables students to learn more than the lecture method. Therefore, it is recommended to use the WebQuest method as one of the effective methods in triage training.
Sleep loss diminishes hippocampal reactivation and replay
Authors: Giri Bapun , Kaya Utku , Maboudi Kourosh , Abel Ted , Diba Kamran
Published: February 2023

Memories benefit from sleep, and sleep loss immediately following learning has a negative impact on subsequent memory storage. Several prominent hypotheses ascribe a central role to hippocampal sharp-wave ripples (SWRs), and the concurrent reactivation and replay of neuronal patterns from waking experience, in the offline memory consolidation process that occurs during sleep. However, little is known about how SWRs, reactivation, and replay are affected when animals are subjected to sleep deprivation. We performed long duration (~12 h), high-density silicon probe recordings from rat hippocampal CA1 neurons, in animals that were either sleeping or sleep deprived following exposure to a novel maze environment. We found that SWRs showed a sustained rate of activity during sleep deprivation, similar to or higher than in natural sleep, but with decreased amplitudes for the sharp-waves combined with higher frequencies for the ripples. Furthermore, while hippocampal pyramidal cells showed a log-normal distribution of firing rates during sleep, these distributions were negatively skewed with a higher mean firing rate in both pyramidal cells and interneurons during sleep deprivation. During SWRs, however, firing rates were remarkably similar between both groups. Despite the abundant quantity of SWRs and the robust firing activity during these events in both groups, we found that reactivation of neurons was either completely abolished or significantly diminished during sleep deprivation compared to sleep. Interestingly, reactivation partially rebounded upon recovery sleep, but failed to reach the levels characteristic of natural sleep. Similarly, the number of replays were significantly lower during sleep deprivation and recovery sleep compared to natural sleep. These results provide a network-level account for the negative impact of sleep loss on hippocampal function and demonstrate that sleep loss impacts memory storage by causing a dissociation between the amount of SWRs and the replays and reactivations that take place during these events.