bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh model project based learning terhadap berpikir kritis peserta didik
Authors: Wirawan Ghina Faridah , Rintayati Peduk , Chumdari Chumdari
Published: August 2024

One important skill that must be developed through school is critical thinking. The use of project-based learning strategies is one technique for improving critical thinking skills. This research seeks to determine the impact of the project-based learning model on students' critical thinking abilities, as well as the effect of implementing the model on these abilities. In addition, this research aims to determine the extent of the influence of the project-based learning model on students' critical thinking abilities at SD Gugus 3 Laweyan Surakarta. This research uses a quasi-experimental design and quantitative methodology. This research uses a pretest-posttest control group design as the research methodology. There are two classes that are the research sample, namely Class 5 and Class 6.
Pengembangan media e-book interaktif ankor (anti korupsi) pada penguatan P5 di kelas IV SDN 1 Sojomerto
Authors: Puspitasari Dewi Sri
Published: August 2024

Penelitian ini bertujuan untuk mengembangkan e-book anti korupsi, kelayakam,
serta kepraktisannya. Latar belakang dari penelitian ini yaitu implementasi P5 yang masih

kurang, selain itu juga pendidikan anti-korupsi terdapat keterbatasan pemahaman guru dan

media pembelajaran untuk diajarkan kepada peserta didik. Kelebihan dari buku ini adalah

penyajian materi yang jelas dan sederhana sehingga mudah untuk dipahami dan dicerna siswa.

Model ADDIE (Analysis, Design, Development, Implementation, and Evaluate) adalah model

yang digunakan dalam penelitian ini. Berdasarkan dari lima tahapan tersebut, pengembangan e-

book anti korupsi menghasilkan persentase dari kedua validator sebesar 85% kategori Layak.

Persentase kepraktisan dari uji respon siswa sebesar 99,25% kategori Sangat Praktis, dan uji

respon guru sebesar 98% kategori Sangat Praktis. Berdasarkan hasil tersebut, e-book anti

korupsi dinyatakan layak dan praktis untuk diterapkan di siswa kelas IV SDN 1 Sojomerto,

Kabupaten Kendal.
Implementasi profil pelajar pancasila dimensi gotong royong dalam pembelajaran IPAS kelas V di sekolah dasar
Authors: Agatha Sherlina Oktavia , Winarni Retno , Supianto Supianto
Published: August 2024

This research aims to describe the implementation of the Pancasila student profile dimension of mutual cooperation in science and science learning for class 5B at elementary school Kestalan Surakarta. This research is analytical descriptive qualitative research. The implementation of the mutual cooperation dimension using the STAD cooperative model in science and science learning for class 5B at elementary school Kestalan Surakarta, which was carried out over three lessons, has been implemented very well by teachers who obtained an average percentage of 81.4%. The teacher has implemented all aspects and indicators of the STAD type cooperative learning model in science learning from opening to closing. The students' mutual cooperation attitude appeared to be very good with an average percentage of 82.68%. All aspects of the mutual cooperation dimension which includes aspects of collaboration, caring and sharing have emerged when researchers conducted observations on students. However, there are still less visible indicators. Thus, further efforts are needed, such as teachers in implementing the mutual cooperation dimension using the STAD cooperative model, should be more innovative and provide more in-depth assistance during group learning. Students should have high motivation, so that they are more serious and actively involved when discussing in groups.
Improved Class of Regression Type Mean Estimators in Simple Random Sampling Using Concomitant Variable: An Application in T-20 International Cricket
Authors: Hussain Mujeeb , Syed Habib Shah  , Azam Sumayyia , Ikram Ullah  , Irshad Muhammad , Nisar Ullah
Published: August 2024

In sample surveys, the information on supplementary variables is usually used to improve the efficiency of the estimators. The ratio, product, and regression estimators are examples. This study proposes new regression estimators for population mean estimation under simple random sampling using the data of Twenty20 (T-20) International Cricket. The estimators are proposed with the help of non-conventional location parameters of concomitant variable which includes Tri-Mean, Mid-Range, and coefficient of quartile deviation. The bias and mean squared error (MSE) of new estimators have been theoretically derived up to the first-order approximation. The theoretical findings were then compared with the existing estimators numerically through simulation study and real-life data. The numerical results reveal that the suggested estimators are more efficient than the estimators in the literature in all conditions.
Time Series Modeling and Forecasting of the Patients’Inflow and Admission in the Hospitals: A cases study of LUMHS Hospital Jamshoro Pakistan
Authors: Sakina Kamboh  , Mir Ghulam Hyder Talpur  , Nawab Khan Chand  , Liaquat Ali Zardari  , Abdul Wasim Shaikh  , Shakeel Ahmed Kamboh
Published: August 2024

The patients’ crowding in the hospitals is an international phenomenon that demands much attention to avoid harm to the lives of patients. The quantitative based models have been successfully investigated to predict the crowding of patients. Thus, the main objective of this study is to probe a statistically feasible forecasting model capable of estimating the crowding of patients (patients’ inflow and patients’ admission specifically). As a case study, the Liaquat University of Medical and Health Sciences (LUMHS) Hospital Jamshoro was chosen. The patients’ secondary data was collected form hospital and commercial computational software MATLAB was used to carry out all the calculations and manipulations by writing a concise user defined program (code). The Autoregressive Integrated Moving Average (ARIMA) modeling approach is adopted to investigate the best forecasting model. It is found that among the various six combinations of ARIMA (p,d,q) the ARIMA (1,0,1) are the best fit models for the patients’ inflow and the patients’ admission respectively; having the lowest AIC, BIC and p-values. Since the forecast accuracy contains minimal contains minimal errors thus forecast trends show very good results. The presented procedure can be helpful to manage the patients’ volume in the hospitals and can also predict the future trend of patients’ inflow and patients’ admission with good accuracy.
Анализ динамики эпидемического процесса COVID-19 в мире за неделю с 24.08.2024 г. по 30.08.2024 г.
Authors: Зимирова Анастасия , Поспелов Михаил , Иванова Александра , Дмитриева Людмила , Чумачкова Елена , Карнаухов Игорь , Щербакова Светлана , Кутырев Владимир
Published: August 2024

В обзоре представлен анализ эпидемиологической ситуации в странах мира по COVID-19 за неделю с 24.08.2024 г. по 30.08.2024 г.
Efektivitas Bimbingan Klasikal Metode Game Based Learning Berbasis Digital dalam Meningkatkan Efikasi Diri Siswa
Authors: Nisa Farihatun , Ris Sumaryani  , Sigit Hariyadi
Published: August 2024

This study aims to determine the effectiveness of classical guidance services using digital-based game-based learning methods to improve students' self-efficacy. This study is an action research on guidance and counseling. The subjects of the study were students of class VIII H of SMP Negeri 31 Semarang. Students' self-efficacy was measured using a self-efficacy scale which was then analyzed using descriptive analysis. The results of this study indicate that in the pre-cycle, the percentage of self-efficacy was 56%, then given action in cycle I, self-efficacy increased to 62%, and then followed up in cycle II, there was also an increase in the level of student self-efficacy to 67%. Thus, it can be concluded that classical guidance using digital-based game-based learning methods is effective in improving students' self-efficacy
Kontrol Diri dan Kematangan Emosi Siswa
Authors: Adelia Ela , Nur Budiono Arifin
Published: August 2024

Education at junior high school level has an important role in shaping students' character and emotional development. One aspect that can influence emotional maturity is self-control. The aim of this research is to determine the relationship between self-control and emotional maturity of class VIII students at SMPN 3. This type of research is quantitative research, this type of research is correlational. The subjects of this research were class VIII students of SMPN 3 TANGGUL for the 2023-2024 academic year. The instrument used was a self-control and emotional maturity questionnaire. Data were analyzed using product moment correlation techniques. The research results show a positive correlation between emotional maturity and self-control of 3.272505. Meanwhile, the r table with degrees of freedom (df 108-2 106) at a significance level of 0.05 obtained a t table value of 1.65936. which means the correlation in the research is significant.
PENGARUH PENGEMBANGAN KARIR, PEMBERDAYAAN KARYAWAN DAN DUKUNGAN ORGANISASI TERHADAP KEPUASAN KERJA KARYAWAN PT. SELECTA BATU
Authors: Virna Nurvitasari Faridhatul , Sedyastuti Kristina , Suryaningtyas Dianawati
Published: August 2024

Kepuasan kerja merupakan salah satu faktor yang penting untuk meningkatkan produktivitas kerja karyawan. Untuk meningkatkan kepuasan kerja diperlukan beberapa faktor. Oleh karena itu penelitian ini mencoba meneliti pengaruh pengembangan karir, pemberdayaan karyawan, dan dukungan organisasi terhadap kepuasan kerja. Pendekatan ini bersifat kuantitatif, dengan sampel 100Â  karyawan menggunakan rumus slovin dan menggunakan teknik proportionate stratified random sampling. Data di analisis menggunakan teknik analisis regresi linier berganda. Hasil penelitian antara lain: sistem pengembangan karir yang optimal juga pemberdayaan organsiasi terhadap karyawan dan dukungan organisasi yang diberikan secara merata memberikan pengaruh terhadap kepuasan kerja karyawan PT.Selecta Batu baik secara parsial atau secara simultan. Saran bagi penelitian selanjutnya sebaiknya menggunakan perusahaan dengan kategori yang berbeda, mempertimbangkan variabel lain yang belum diteliti atau menambahkan variabel lain.
PENGARUH MOTIVASI, KOMITMEN ORGANISASI, DAN KOMUNIKASI TERHADAP KINERJA PEGAWAI BADAN PERTANAHAN NASIONAL KABUPATEN MALANG
Authors: Fajaruddin M , Nu Graha Andi , Wilujeng Sri
Published: August 2024

Penelitian ini bertujuan untuk mengetahui pengaruh motivasi, komitmen organisasi, dan komunikasi terhadap kinerja pegawai Badan Pertanahan Nasional Kabupaten Malang. Populasi di dalam penelitian ini adalah 38 pegawai tetap. Teknik sampling yang digunakan adalah teknik sampling jenuh adapun data yang diperoleh melalui penyebaran kuesioner terhadap responden. Teknik analisis data yang digunakan dalam penelitian ini yaitu regresi linier berganda menggunakan SPSS. Hasil dari penelitian ini menyatakan bahwa secara simultan motivasi, komitmen organisasi, dan komunikasi berpengaruh secara signifikan terhadap kinerja pegawai. adapun hasil secara parsial motivasi kerja berpengaruh secara signifikan, sedangkan komitmen organisasi dan komunikasi tidak berpengaruh secara signifikan. Berdasarkan penelitian ini perlu adanya peningkatan dalam diri pegawai untuk memiliki kemauan agar mengusahakan kepentingan organisasi tercapai dan pegawai maupaun pimpinan harus melakukan komunikasi dengan menyampaikan tugas kepada pegawai dengan bahasa yang baik dan mudah dimengerti agar tidak terjadi miss communication.
PENGARUH HARGA, CITRA RASA, KUALITAS PELAYANAN DAN PROMOSI TERHADAP KEPUASAN PELANGGAN SEBLAK MAMANG NDUT KOTA MALANG
Authors: Kristina Ola , Rusno Rusno , Wahyu Hidayat Candra
Published: August 2024

Tujuan dari riset ini yaitu untuk menganalisis pengaruh harga,citra rasa,kualitas pelayanan dan promosi terhadap kepuasan pelanggan. Penelitian dilakukan dengan pendekatan kuantitatif serta sampel yang didapatkan didasarkan pada Teknik purposive sampling yaitu Teknik pengambilan sampel sesuai dengan ketentuan yang telah ditetapkan sebelumnya. Analisis menggunakan metode regresi linier berganda. Berdasarkan hasil analisis dibuktikan variabel harga, cita rasa, kualitas pelayaan dan promosi secara stimultan dan signifikan berpengaruh positif terhadap kepuasan pelanggan, serta secara parsial berpengaruh positif dan signifikan terhadap kepuasan pelanggan. Hal yang sama juga terjadi pada variabel cita rasa dan kualitas pelayanan yang secara parsial berpengaruh positif secara signifikan terhadap kepuasan pelanggan. Begitu pula dengan promosi sebagai variabel yang memiliki pengaruh yang positif terhadap kepuasan pelanggan.
PENGARUH CUSTOMER EXPERIENCE, PROMOSI DAN KUALITAS PELAYANAN TERHADAP KEPUASAN PELANGGAN PADA CHALLISTA BEAUTY SALON DI KOTA MALANG
Authors: Indrawati Teresia , Nurfarida Iva Nurdiana , Puspitosari Arien Anjar
Published: August 2024

Penampilan menarik menjadi keinginan banyak individu di era saat ini, terutama melalui perawatan di salon kecantikan. Challista beauty Salon, salah satu salon unisex di Kota Malang, berupaya mempertahankan pelanggan dengan menawarkan pengalaman positif dan memberikan pelayanan yang berkualitas kepada konsumennya. Kepuasan pelanggan adalah prioritas utama, karena mempengaruhi kinerja dan reputasi bisnis. Penelitian ini bertujuan untuk menentukan apakah Customer Experience, Promosi dan Kualitas Pelayanan berpengaruh terhadap Kepuasan Pelanggan Challista Beauty Salon di Kota Malang. Customer Experience, Promosi dan Kualitas Pelayanan adalah variabel bebas dalam penelitian ini dan kepuasan Pelanggan sebagai variabel terikat. Jenis penelitian ini yaitu explanatory research Pelanggan Challista Beauty Salon adalah subjek dalam penelitian yang dilakukan di Kota Malang. Teknik pengambilan sampel yang digunakan adalah teknik Probability Sampling dimana jenis pengambilan sampel ini tidak acak, dan informasinya diperoleh melalui pertimbangan tertentu. Studi ini menggunakan analisis Regresi linear berganda dan mendapatkan hasil bahwa secara secara bersamaan (uji F) variabel bebas berpengaruh terhadap variabel terikat dan juga secara parsial (uji T) memiliki pengaruh dari ketiga variabel bebas terhadap kepuasan pelanggan baik itu secara positif maupun secara signifikan.
PENGARUH MARKETING MIX TERHADAP KEPUASAN PELANGGAN PADA CV. MAXIMA GLOBAL MALANG
Authors: Ardianto Sofi , Nurfarida Iva Nurdiana , Hidayat Candra Wahyu
Published: August 2024

ABSTRAK : Persaingan di Indonesia semakin meningkat karena penjualan di negara ini tumbuh lebih cepat. Namun, masih ada permintaan dari pelanggan dalam jumlah tertentu. Oleh karena itu, meskipun tidak mengabaikan tugas-tugas bisnis lainnya, fungsi pemasaran kini memegang peranan yang semakin besar dalam operasi perusahaan. Semua bisnis, bahkan yang bergerak dalam penjualan produk, dapat memperoleh manfaat dari penggunaan strategi pemasaran berdasarkan analisis bauran pemasaran. Empat faktor yang membentuk bauran pemasaran: sistem distribusi, struktur harga, produk, dan aktivitas promosi. Karena keempat komponen bauran pemasaran saling bergantung dan berdampak satu sama lain, maka perlu dilakukan upaya untuk mengembangkan strategi pemasaran yang meningkatkan kepuasan pelanggan dan keberhasilan layanan. Tujuan penelitian ini adalah untuk mengetahui bagaimana bauran pemasaran mempengaruhi kebahagiaan konsumen. Penelitian untuk penelitian ini dilakukan di CV.Maxima Global Malang. Dengan menggunakan pengambilan sampel analisis faktor, 105 responden diidentifikasi sebagai sampel, yang jumlahnya setidaknya empat atau lima kali lipat dari jumlah variabel. Kuesioner menggunakan skala likert untuk pengukurannya. Temuan penelitian menunjukkan bahwa kepuasan pelanggan CV dipengaruhi secara bersamaan oleh produk, harga, distribusi, dan promosi. Maxima Internasional. Produk berdampak signifikan dan menguntungkan terhadap kepuasan pelanggan CV. Global Maxima Malang. Kepuasan pelanggan pada CV dipengaruhi secara positif dan signifikan oleh harga. Global Maxima Malang. Kepuasan pelanggan pada CV dipengaruhi secara positif dan signifikan oleh distribusi. Global Maxima Malang. Kepuasan pelanggan pada CV dipengaruhi secara positif dan signifikan oleh promosi. Global Maxima Malang. Hal ini dimaksudkan agar dunia usaha atau manajemen perusahaan mempertimbangkan temuan penelitian ini ketika mengambil keputusan, terutama dalam hal strategi bauran pemasarannya.
PENGARUH LEVERAGE, UKURAN PERUSAHAAN DAN PROFITABILITAS TERHADAP NILAI PERUSAHAAN (STUDI EMPIRIS PADA PERUSAHAAN MAKANAN DAN MINUMAN YANG TERDAFTAR DI BEI PERIODE 2020-2022)
Authors: Mollu Katrina Baba , Asna Asna , Tyasari Irma
Published: August 2024

Penelitian ini bertujuan untuk menguji pengaruh leverage, ukuran perusahaan dan profitabilitas terhadap nilai perusahaan. Leverage diukur dengan Debt to Equity Ratio (DER), ukuran perusahaan menggunakan Ln total aset, profitabilitas diukur menggunakan Return On Asset (ROA) dan nilai perusahaan diukur menggunakan Price Book Value (PBV). Jenis penelitian ini adalah menggunakan metode kuantitatif. Populasi dalam penelitian ini yaitu perusahaan makanan dan minuman yang terdaftar di Bursa Efek Indonesia (BEI) periode 2020-2022. Teknik pengambilan sampel ialah metode purposive sampling, sehingga diperoleh sebanyak 57 amatan perusahaan makanan dan minuman yang telah memenuhi kriteria-kriteria yang telah ditetapkan dengan jumlah data yang digunakan. Sumber data yang digunakan  ialah  data  sekunder  berupa annual  report yang  diperoleh  dari Bursa Efek Indonesia. Dalam penelitian ini, teknik analisis data yang digunakan   yaitu   analisis   regresi   linear   berganda. Hasil penelitian menunjukkan bahwa Leverage, Ukuran Perusahan dan Profitabilitas secara bersama-sama berpengaruh terhadap nilai perusahaan. Secara parsial menunjukkan bahwa Leverage berpengaruh terhadap nilai perusahaan, sedangkan ukuran perusahan dan profitabilitas tidak berpengaruh terhadap nilai perusahan.
PENGARUH STORE ATMOSFER, KUALITAS PELAYANAN DAN HARGA TERHADAP PEMBELIAN IMPULSIF PADA PRODUK 3SECOND MATOS KOTA MALANG
Authors: Nor D. Ahmad Affaniy , Rusno Rusno , Sarwoko Endi
Published: August 2024

Sebelum melakukan pembelian, pembeli terlebih dahulu berniat membeli barang yang dibutuhkannya. Ada kalanya proses pembelian pembeli terjadi begitu saja tanpa persiapan sebelumnya. Pengadaan seperti ini disebut dengan drive purchase. Banyak elemen yang dapat mempengaruhi dorongan pembelian di kalangan pelanggan, salah satunya adalah lingkungan toko, kualitas pelayanan, dan biaya. Maksud dari penjajakan ini adalah untuk menambah konsentrasi terkait dampak iklim toko, kualitas pelayanan, dan biaya tanpa terlalu memikirkan pembelian produk Matos 3Second Kota Malang. Strategi dalam pemeriksaan ini adalah dengan menggunakan eksplorasi kuantitatif, ilmuwan mengambil objek pemeriksaan barang 3Second Matos di Kota Malang dan menjadikan pembeli sebagai subjek pemeriksaan dan masyarakat. Dengan menggunakan prosedur pemeriksaan kebetulan, jumlah contoh adalah 160 responden, yang kemudian diselidiki menggunakan SPSS'22 dengan strategi relaps langsung yang berbeda. Hasil penelitian ini menunjukkan adanya pengaruh yang timbul karena faktor suasana toko(store atmosphere), kualitas pelayanan dan biaya atau yang biasa disebut harga terhadap pembelian impulsif baik secara bersamaan maupun sendiri-sendiri.
PENGARUH MOTIVASI KERJA TERHADAP KINERJA PEGAWAI DIMEDIASI OLEH KEPUASAN KERJA (DI KANTOR DINAS LINGKUNGAN HIDUP KOTA MALANG)
Authors: Emon Venansius Yunus , Sarwoko Endi , Suryaningtyas Dianawati
Published: August 2024

Dalam mengetahui bagaimana kepuasan kerja, motivasi, dan kinerja pada Dinas Lingkungan Hidup Kota Malang saling berhubungan satu sama lain merupakan tujuan dari penelitian ini. Pendekatan penelitian yang digunakan dalam penelitian ini adalah deskriptif kuantitatif. Dari dua ratus pegawai Dinas Lingkungan Hidup Kota Malang, enam puluh tujuh orang dipilih sebagai sampel penelitian. Perangkat lunak SPSS digunakan sebagai bagian dari pendekatan analisis data dalam penelitian, yang disebut sebagai “jalur analisis”. Penelitian menunjukkan bahwa motivasi kerja mempunyai pengaruh yang baik terhadap kinerja karyawan. Kinerja karyawan dan metrik kepuasan kerja berkorelasi positif. Hubungan antara kinerja pegawai dengan motivasi kerja dimediasi oleh variabel kepuasan kerja.
PENGARUH HARGA, FASILITAS, DAN LOKASI TERHADAP KEPUASAN PENGUNJUNG DI TAMAN SAFARI II PRIGEN PASURUAN
Authors: Manajer Jurnal
Published: August 2024

Penelitian ini bertujuan untuk mengetahui pengaruh harga, fasilitas, dan lokasi terhadap kepuasanpengunjung yang ada di Taman Safari II Pasuruan. Populasi dalam penelitian ini adalah pengunjung Taman Safari II. Contoh yang digunakan adalah 112 responden. Strategi Penelitian menggunakan teknik kuantitatif. Hasil pengujian juga menunjukkan bahwa uji coba variabel harga, fasilitas, dan lokasi secara bersama-sama mampu memberikan dampak yang signifikan pada kepuasanpengunjung yang ada di Taman Safari II Prigen Pasuruan.
PEMODELAN PREDIKSI KUANTITAS PENJUALAN MAINAN MENGGUNAKAN LightGBM
Authors: Febriantoro Erfan , Setyati Endang , Santoso Joan
Published: August 2024

Ciri khas utama industri mainan adalah perubahan dan ketidakpastiannya yang cepat. Permintaan yang dipengaruhi oleh tren tertentu, dapat berubah secara mendadak dan tiba-tiba menghilang saat produk viral berikutnya menguasai pasar. Inovasi produk yang konstan, siklus hidup yang pendek, dan tingkat kanibalisasi yang tinggi berpotensi mengeluarkan biaya relatif lebih tinggi dibandingkan dengan industri lain dalam hal persediaan usang, kehilangan penjualan, dan penurunan harga. Berdasarkan permasalahan tersebut maka dilakukan penelitian untuk memprediksi penjualan mainan menggunakan model algoritma LightGBM dalam bentuk time-series dengan dataset penjualan 460 item mainan yang diklasifikasikan menjadi 14 kategori dalam rentang waktu 1.353 hari dengan periode prediksi 1, 3, dan 6 bulan. Penelitian ini menghasilkan 42 model berdasarkan kategori produk dan periode prediksi, dengan nilai RMSE terbaik 0.0042 pada model mainan KARTU, dan 3 model untuk semua kategori berdasarkan periode prediksi dengan nilai RMSE terbaik 0.0380 pada periode prediksi 1 bulan.
Sorghum Entrepreneur Marketplace Using K-Medoid Clustering
Authors: Saurina Nia , Noerhartati Endang , Revitriani Marina
Published: August 2024

Marketplace is a virtual market where the market is a meeting place for buyers and sellers to make transactions. Wijaya Kusuma University Surabaya has established an Entrepreneurship Sorghum Unit (UES) starting in 2009 and is collaborating with Sorghum Entrepreneurs in several areas in East Java. The objectives of this research are: (1) creating a marketplace for Sorghum Entrepreneurs who have joined UES, (2) Classifying using the K-Medoid method to group Sorghum Entrepreneurs based on the income that has been obtained by UES, (3) Conducting mapping based on clustering results so that UES can provide assistance to sorghum entrepreneurs. From the results of the questionnaire, obtained data on the level of desire for UES for each variable from 35 sorghum entrepreneurs as respondents. Quantitative data obtained is then entered and then proceed with the clustering stage. The data is divided into several clusters based on the type of sorghum, products sold and sales results. After that, the cluster performance calculation is carried out by calculating the k-fold value. analysis of the results of testing the effect of the k-fold value is the best percentage found in the k-fold value = 6 with an accuracy value of 34.597%.
Subclinical Mastitis Dynamics in Response to the Use of Autogenous Vaccine
Authors: Faria Ana Cláudia Fagundes , Campos Carla , Dutra Paulo César Franco , Zanforlin Felipe , França Roberta Tomaz Botta , Borges Isabela Pacheco , de Paula José William Maluf , Santos Ricarda Maria dos
Published: August 2024

The objective was to evaluate subclinical mastitis dynamics and clinical mastitis monthly rate in response to use of an autogenous vaccine. Lactating dairy cows were enrolled into two groups: Vaccinated (n = 300) and Control (n = 300). To identify the herd mastitis microbiological profile, CMT test were conducted, and positive milk samples were submitted to microbiological culture. Corynebacterium bovis, Escherichia coli, Staphylococcus chromogenes, Streptococcus agalactiae, Streptococcus dysgalactiae and Streptococcus uberis showed a high isolation rate and were used in autogenous vaccine manufacturing. The first vaccination occurred in March 2022 and the booster 30 days later. Blood samples from 10% of each group were collected every 30 days for seroconversion analysis by ELISA. Data of monthly clinical mastitis and individual SCC were evaluated by T-test (GraphPad Prism; P < 0.05). Vaccination stimulated the cows’ immune system to produce specific antibodies against vaccine bacteria. The individual monthly SCC average were lower for Vaccinated than in Control group. In subclinical mastitis dynamics, Vaccinated group showed a higher number of healthy and cured cows, and a lower number of cows with new infections and chronic cows. No difference was observed in clinical mastitis rate among groups. In conclusion, autogenous vaccine appropriately stimulates immune system, reduces the individual monthly SCC average, increases the number of healthy and cured cows and reduces the number of cows with new infections and chronic cows in a crossbred dairy herd.
WITHDRAWN: LC-HRMS based metabolite profiling of black wheat rawa idli incorporated panner whey powder reveals key bioactive compounds
Authors: Aggarwal Ankur , Verma Tarun
Published: August 2024

The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Surface Potential as the Parameter of the Effective Control of Sorption Properties of Zeolites
Authors: Badalyan Hamlet , Sargsyan Hovhannes , Harutyunyan Lusine , Harutyunyan Romik
Published: August 2024

The natural sorbents are undergoing physical and chemical modification for the improvement of their sorption and ion-exchange properties. In the presented paper the effect of physical modification on the sorption ability of zeolites has been studied and the methodology of the evaluation of the sorption ability of physically modified zeolites has been suggested based on the value of surface potential. The physical modification of zeolites has been carried out by the influence of infrared, ultraviolet, X-ray waves and by the beam of electrons. It has been established that for sorption of metals’ ions-isotopes the more effective is modification by the beam of electrons. By the computer simulation it has been shown that the surface potential of the sorbent is the summary parameter for the evaluation of the modification effectiveness and the sorption ability of zeolites and that it is related to topography of the distribution of thepotential on the surface.
Exploring the mechanisms of Shenmai injection against Chronic Obstructive Pulmonary Disease based on network pharmacology and molecular docking validation
Authors: LIU Xiaolin , GONG Jingru , Chen Yang , Lu Yi , Dan Qu , LU Huiping
Published: August 2024

Background Chronic obstructive pulmonary disease (COPD) is a common respiratory disease with high morbidity and mortality. The conventional therapies remain palliative and have various undesired effects. Shenmai injection (SMI) has shown positive effects on COPD, but its molecular mechanisms are still unclear. This study aims to investigate the bioactive ingredients and underlying mechanisms of SMI in treating COPD based on network pharmacology analysis and molecular docking validation.
Methods Active ingredients in SMI were sourced from the TCMSP, SymMap, and BATMAN-TCM databases, with their targets predicted using Swiss target prediction. Potential COPD targets were obtained from the GeneCards, OMIM and GEO databases. Cytoscape software was employed to construct the candidate component-target network for SMI in treating COPD. Furthermore, the functions and signaling pathways of shared targets between SMI and COPD were enriched by GO and KEGG analyses. Finally, molecular docking studies of key active ingredients and hub targets were performed using Autodock vina software.
Results A total of 28 active components were identified, corresponding to 606 targets, including 341 common targets shared by the active components and COPD. The top 10 hub targets were screened, namely STAT3, SRC, EGFR, HSP90AA1, AKT1, IL6, TNF, BCL2, JUN and CCND1. GO enrichment analysis yielded 127 entries for biological processes (BP), 32 for cellular components (CC), and 33 for molecular functions (MF). The significantly enriched iterms in BP, CC, and MF enrichment were associated with response to xenobiotic stimulus, plasma membrane, and protein serine/threonine/tyrosine kinase activity, respectively. KEGG enrichment analysis identified 189 significantly enriched pathways, primarily including pathways in cancer, PI3K-Akt signaling pathway and chemical carcinogenesis- receptor activation. These pathways play roles in the effect of SMI on treating COPD. Molecular docking results demonstrated the effective binding of the primary active ingredients (Ophiopogonanone A, Ruscogenin, Stigmasterol) to their respective targets (EGFR, AKT1, HSP90AA1).
Conclusion SMI treats COPD through a multi-component, multi-target, and multi-pathway synergistic network, providing a basis for further exploration of SMI's mechanisms in COPD treatment.
The snake-venom-nerve growth factor-inspired custom peptide downregulates two novel miRNAs (cel-miR-8207-3p and cel-miR-57-3p) for neuroprotection against paraquat-induced toxicity in Caenorhabditis elegans
Authors: Madhubala Dev , Khan Mojibur R. , Mukherjee Ashis K.
Published: August 2024

Parkinson's disease (PD) represents a significant global health challenge influenced by environmental factors and the accumulation of alpha-synuclein. MicroRNAs (miRNAs), crucial regulators of gene expression, play pivotal roles in neurodegenerative processes. This study is structured into two primary investigations. Firstly, miRNA microarray analysis in Caenorhabditis elegans treated with mouse 2.5 S-NGF and custom peptide (HNP) revealed distinct expression profiles, notably upregulating miR-1-3p and miR-255-3p compared to controls. Pathway analysis implicated these miRNAs in neuroprotective mechanisms, including PI3K, Wnt/β-catenin, and TGF signalling, while downregulated miRNAs were associated with apoptosis, p53, and innate immunity pathways. These results underscore the neuroprotective roles of NGF and HNP through miRNA-mediated mechanisms in C. elegans. Secondly, a comparative analysis of global miRNA profiles between paraquat-induced PD model worms and NGF/HNP-treated worms identified novel miRNAs and revealed inverse expression patterns indicative of miRNA profile restoration by NGF/HNP pre-treatment. Principal component and correlation analyses demonstrated distinct miRNA regulation profiles across treatments. Gene network analysis identified target mRNAs involved in diverse cellular processes, highlighting potential therapeutic roles of NGF and HNP in neurodegenerative diseases like Parkinson's, mainly through regulation of miR-4813-3p associated with α-synuclein clearance. These findings underscore the promise of NGF and HNP as therapeutic strategies targeting neurodegenerative mechanisms mediated by miRNAs.
High-Content Graphitic-N Self-Doped Porous Carbon Catalyst Derived from Seaweed for Efficient Oxygen Reduction Reaction
Authors: Zhang Junjie , Xia Maosong , Wang Jilong , Wu Chao , Li Shixin , Liu Long , Wei Wuguo
Published: August 2024

Academic interest in fuel cell technology is steadily increasing due to the demand for developing an affordable and effective biomass-derived catalyst for oxygen reduction reaction (ORR) to replace Pt-based catalysts. Nine groups of graphitic-N and pyridinic-N models are designed and analyzed using density functional theory (DFT). These results reveal that the ORR energy barriers for high-content graphitic-N models are only 0.10 eV and 0.11 eV, significantly lower than the 0.88 eV and 0.96 eV for pyridinic-N models, indicating that high-content graphitic-N structures are theoretically advantageous. High-protein seaweed is screened as a precursor to synthesize directionally high-content graphitic-N (3.56 at%) self-doped porous carbon ORR catalyst (S-850). The graphitic-N content of S-850 exceeds that of previously reported biomass-derived carbon-based ORR catalysts. Compared to 20% Pt/C (0.862 V and 5.60 mA cm− 2), S-850 (0.843 V and 5.24 mA cm− 2) exhibits only a 19 mV decrease in half-wave potential and a 0.36 mA cm− 2 decrease in limiting diffusion current density. S-850 also demonstrates superior stability and tolerance to methanol and CO compared to 20% Pt/C. Guided by DFT calculations, this study conducted the directional synthesis of high-performance, low-cost biomass-derived carbon-based ORR catalysts, offering a paradigm for future research.
Association of insufficiency fruits and vegetables consumption and cardiovascular diseases risk among beverage industrial workers and their spouses in Rwanda
Authors: Nsanzabera Charles , Bizumuremyi Colombe , Ndabihawenimana Désirée
Published: August 2024

Background
Cardiovascular diseases risk and premature death have been associated with low fruits and vegetables intake. Around 5.6 to 7.8 million of global premature deaths were declared due to insufficient intake of fruits and vegetables. The objective of this study was to assess the association between fruits and vegetables intake and fatal and non-fatal cardiovascular disease (CVD) risk.
Methods
Employing a cross-sectional analytical design, 440 study participants aged between 30 and 75 years participated in this study using Cochrane sample size formula and stratified random sampling combined with simple random sampling. Stepwise questionnaire, clinical forms and biological blood samples were used to get socio-demographic, fruits, and vegetables(F&V) data and prior information for predicting the cardiovascular risk with cox regression analysis through Framingham general risk score. Chi-square and logistic regression statistical analysis were used to assess the association between F&V intake and categorized cardiovascular diseases risk (low CVD risk:<10% and elevated CVD risk > = 10%). The significance threshold was set at p < 0.05 and 95%CI.
Results
The findings of this study revealed that the mean age was 44.92 years with interquartile range of IQR: 45(38-51.75). Around 75.9% of study participants consumed vegetables for two days and fewer in a typical week, and 79.8% of participants were found to consume less than one serving. Additionally, consuming vegetables below three days in a typical week was associated with elevated cardiovascular disease risk ( > = 10%) with AOR: 5.869, 95% CI: 2.710-12.714, p < 0.001. Having less than one serving of vegetables or consuming none were associated with a twofold increase in elevated cardiovascular disease risk ( > = 10%) with AOR: 2.135, 95% CI: 1.136–4.010, p = 0.01. Moreover, consuming less than one serving of fruits was associated with a fourfold increase in elevated cardiovascular disease risk ( > = 10%) with AOR: 4.41, 95% CI: 1.938–10.042, p < 0.001.
Conclusion
This study concludes that consuming a low quantity of servings and infrequent intake of fruits and vegetables in a typical week is associated with an elevated risk of cardiovascular diseases ( > = 10%).
The Critical Role of Valuation in Supporting Phu Quoc's Tourism Revenue
Authors: Ngo-Hoang Dai-Long
Published: August 2024

Phu Quoc, a large island in Vietnam's Southwest Sea, holds a strategic position in terms of economics, politics, defense, and security. The island is endowed with a favorable climate, diverse terrain, and rich biological resources, which have made tourism a key driver of local development. This study aims to estimate the economic value generated by tourism activities on Phu Quoc Island, thereby emphasizing the potential for ecotourism. The research employs the Zonal Travel Cost Method (ZTCM) to assess this value, utilizing data from the People's Committee of Phu Quoc district and a sample of survey respondents. The findings reveal the significant economic contributions of ecotourism, demonstrating the island's capacity to generate substantial tourism revenue. The study concludes that Phu Quoc has immense potential for generating tourism welfare, provided that infrastructure is well-developed, recreational activities are diversified, and the ecological environment is sustainably protected. These insights offer valuable guidance for policymakers in planning and managing the sustainable development of ecotourism on Phu Quoc Island.
Role-Playing Game in Developing Foreign Language Skills in Preschool Children
Authors:   Baranovichi State University, Shovgenya Margarita M.
Published: August 2024

The formation of foreign language skills in preschool children with the help of story-role play is of high relevance and importance due to the fact that knowledge of foreign languages becomes an important skill that helps to successfully adapt in society and in the labor market. The role-playing game allows children to get involved in communication in a foreign language, to apply the acquired skills in practice and to learn new vocabulary and grammar. The novelty of the research is determined by characterizing the functions of the story-role play in early foreign language teaching, describing the role of the story-role play in the process of formation of foreign language speech skills in preschool children, creating with its help an artificial language environment in the classroom. The specifics of using the speech and communicative approach in teaching foreign languages to preschool children are described. The diagnostic table of formation of foreign language communicative competence of preschool children in the story-role play is developed. The author considers the factors that determine the choice of methods and approaches to early foreign language teaching. The author describes the peculiarities of the development of the emotional-volitional sphere, the sphere of self-conscious-ness, cognitive and speech development. Conversation in a foreign language is one of the main exercises in learning. The author has analyzed the functions of the story-role play in early learning a foreign language, types of motivation, attributes of creating an artificial language environment. The use of story-role-play in the creation of artificial language environment is characterized. The process of realizing the components of foreign language communicative competence is described. In the process of research such research methods as generalization of research results in the field of early foreign language teaching methodology and finding general regularities by processing and interpreting these results, analysis of components of foreign language communicative competence are used. The prospect of the research the author designates in studying the development of foreign language speech skills of preschool children in situations of communication in an artificial language environment in the classroom in the process of using a role-playing game.
Interdisciplinary Connections: An Integrative Foreign Language Learning Environment at a Civil Engineering University
Authors:   Moscow State University of Civil Engineering, Metelkova Liliia A. , Khrisanova Elena G. ,   Chuvash State Pedagogical University I. Ya. Yakovlev, Root Evelina V. ,   Moscow State University of Civil Engineering
Published: August 2024

At present, the interaction between different areas of knowledge is becoming an integral part of our life, which has resulted in the research interest in interdisciplinarity in the system of higher professional education. The interdisciplinary approach to teaching foreign languages in higher education makes it possible to combine knowledge and skills from various fields to solve complex problems that students will face in their future professional environment. The next factor that determines the relevance of the problem under study is the specific character of the “Foreign Language” discipline. Professionally oriented foreign language instruction involves close interaction between the participants of the educational process beyond linguistic aspects. The study represents a theoretical stage and considers the problem of creating an integrative foreign language learning environment at NR Moscow State University of Civil Engineering. An analysis of domestic and foreign pedagogical and methodological literature on the research topic has been carried out through theoretical (analysis of methodological literature, synthesis, generalization) and practical (questioning of students and teachers) methods. Identifying interdisciplinary connections is considered a necessary condition for creating an integrative foreign language learning environment. Domestic and foreign studies of the teachers and methodologists demonstrate the depth and sufficient elaboration of specific issues of the interdisciplinary approach. However, practical teaching experience shows that some theoretical aspects do not correspond to the real educational environment. This imbalance is based on the conditions that are considered in the study. Based on the analysis, recommendations for successful implementation of the interdisciplinary approach to professionally oriented language instruction at the civil engineering university have been developed: integration of educational materials on construction; project-based learning, cross-cultural learning; use of interactive technologies; cooperation with the teachers of engineering disciplines; educational and methodological seminars for teachers.
Alternative Methodology for Retrospective Analysis of the “Children`s Movement” Phenomenon in Russia late 19 th – early 21 st centuries
Authors:   Herzen State Pedagogical University of Russia, Onishchenko Eleonora V.
Published: August 2024

The article in the genre of scientific notes considers the main stages of genesis of the phenomenon of “children’s movement” of the late XIX – early XXI centuries. in Russia. The assessment of the design and development of this socio-cultural phenomenon is offered as part of the approbation of paradigm methodology. A retrospective analysis of the peculiarities of the “children’s movement” is given in the context of presentation of a consistent change of 3 conceptual paradigms: “pedocentrist”, “sociocentrist”, “institutocentric”, characteristic for the historiogenesis of sociokinetics, as a special scientific field. These models have different, inherently universal orientations, determined by the need to take into account the alternative needs of its various actors – the children’s or professional-pedagogical community itself (as leading educators as a basic social institution). Characteristic features of such models transformation in terms of modernization of the dominant ideological position in Russia in relation to childhood and its subculture have been declared. A brief description of the procedure of initiation and creation of diverse in content and forms of organization of activities of children’s associations in the context of substantiation of the possibility of using the results of the analysis for their practical reconstruction during the Training for future teachers. The novelty of retrospective analysis is connected with the fact that the historical experience of the registration of the children’s movement (as a special scientific direction – sociokinetics) is considered from the point of view of activation of involvement of children and youth in sociocultural activity in modern conditions, as well as the potential prospects of its modern reassessment and interpretation.
Formation of Universal Educational Actions of Younger Students in Scientific and Aesthetic Knowledge
Authors:   Transbaikal State University, Kurganskaya Alla V.
Published: August 2024

The article is devoted to identifying universal educational actions that contribute to more successful aesthetic knowledge by younger students. The relevance of the study lies in the fact that in modern pedagogical science and in the federal state educational standards of primary general education, an approach to understanding universal educational actions as well as actions in the field of scientific knowledge is presented, which does not correspond to the formation of universal educational actions of younger students in the field of aesthetic knowledge. The purpose of the article is to identify universal educational actions that contribute to a more successful aesthetic knowledge of younger students. To achieve this goal, such methods as analysis, systematization, generalization are used. The author notes that the universal educational actions of younger schoolchildren are formed mainly in the process of scientific knowledge, and in the lessons of the aesthetic cycle (literary reading, visual arts, music) it is necessary to form universal educational actions that contribute to the formation of skills in younger schoolchildren to analyze, interpret a work of art, identify the author’s attitude and his own to the work. The author correlates the formed universal educational actions of younger schoolchildren in the process of scientific and aesthetic knowledge. It is revealed that universal educational actions of scientific knowledge do not always contribute to the full communication of younger schoolchildren with works of art. The author defines the universal educational actions of younger students in the field of aesthetic cognition: perception of visual and expressive means of the language of art, knowledge of their functions in a work of art; recreating pictures of life created by the author of a work of art; establishing casual relations, analyzing the logic of action development in a work of art; holistically perceiving the image in a work of art; determining the author’s position in a work of art; comprehending the artistic idea of a work of art.