bluuebunny/crossref_metadata_2025 huggingface dataset:
Broken Machines or Active Bodies? Part 1. Ways of Talking About Health and Why It Matters
Authors: Bunzli Samantha , Taylor Nicholas F. , O'Brien Penny , Wallis Jason A. , Caneiro J.P. , Woodward-Kron Robyn , Hunter David J. , Choong Peter F. , Dowsey Michelle M. , Shields Nora
Published: April 2023

SYNOPSIS: This editorial series raises awareness among clinicians about how ways of talking about orthopaedic conditions can influence what people who are seeking health care (1) think about their health and (2) what they do to manage their health. In part 1, we introduce you to ways of talking about health, using osteoarthritis as a case study. In part 2, we describe 2 contrasting ways of talking about osteoarthritis and how changing the way you share information and ideas with people seeking care may impact clinical decisions. In part 3, we offer strategies to help you shift the way you communicate with people with osteoarthritis to promote uptake of best practice recommendations and support healthy, active lifestyles. J Orthop Sports Phys Ther 2023;53(5):236–238. doi:10.2519/jospt.2023.11879
Post–COVID-19 Syndrome Clinical Pathway for the US Veterans Health Administration
Authors: Campos Claudia , Nguyen Cristina , Crothers Kristina , Awan Omar , Miller Francis , Sedillo Courtney , Vachachira Johnson , May Carrie , Gustavson Allison , Lindheimer Jacob
Published: April 2023

The Department of Veterans Health Affairs (VHA) has launched 22 multispecialty post–COVID-19 clinics across the US for the growing number of veterans experiencing long-term sequelae after acute COVID-19 infection. While evidence-based treatments for this syndrome are under investigation, there is a critical need to establish and disseminate clinical pathways (CPWs) based on knowledge and experience gained in those clinics. This VHA CPW is intended to guide primary care clinicians who care for patients experiencing dyspnea and/or cough during post–COVID-19 syndrome (PCS), which includes symptoms and abnormalities persisting or present beyond 12 weeks of the onset of acute COVID-19. This effort will help guide and standardize the care of veterans across the VHA, improve health outcomes, and effectively utilize health care resources. This article summarizes our stepwise diagnostic approach for patients presenting with PCS dyspnea and/or cough in primary care; it also highlights teleconsultation and telerehabilitation as opportunities to reach those in rural areas or with transportation barriers and improve reach for specialized services.
Patient Perspectives About Cancer Clinical Pathways and Care Coordination
Authors: Collyar Deborah
Published: April 2023

While health care leaders may ultimately want to create better care for patients, systemic goals can be at odds with individual patient needs. Before finalizing clinical pathways, patient needs must be intentionally assessed to en­sure pathways that work for providers can also deliver flexible and effective pa­tient care for the entire spectrum of patients and their families. Tools should en­compass the entire patient experience, from ways to avoid cancer, how to obtain a diagnosis and biomarker testing, and participation in clinical trials, to treatment decisions, survivorship plans, and end-of-life support. This article discusses how patients feel through their cancer experience and suggests ways to incorporate important components like social determinants of health; diversity, equity, and inclusion strategies; and cost considerations so patients can live full lives.
THE INFLUENCE OF THE DISPERSION OF CRUSHED SANDSTONE OVERBURDEN OF COAL MINING ON THE PROPERTIES OF THERMAL INSULATION MATERIAL
Authors: Кара-сал Б.К. , Стрельников А.Н. , Натпит-оол А.А. , Саая Б.О.
Published: April 2023

Показана возможность получения пористого теплоизоляционного материала в виде гранул из песчаниковых вскрышных пород угледобычи, как альтернативное алюмосиликатное сырье техногенной основы. Выявлено, что на основе шихты, состоящий из 75% песчаника, 20% кальцинированной соды и 5% известняка получены гранулы с объемной насыпной массой 310–480 кг/м3 и прочностью при сжатии 2,1–3,2 МПа. Установлено, что на спекание, расплавление и вспенивание массы влияет дисперсность измельченного материала, где с уменьшением размера частиц повышается химическая активность компонентов.

The possibility of obtaining a porous thermal insulation material in the form of granules from sandstone overburden rocks of coal mining as an alternative aluminosilicate raw material of technogenic basis is shownin the article. It was revealed that on the basis of a charge consisting of 75% sandstone, 20% soda ash and 5% limestone, granules with a volumetric bulk mass of 310–480 kg/m3 and a compressive strength of 2.1–3.2 MPa were obtained. It is established that the sintering, melting and foaming of the mass is affected by the dispersion of the crushed material, where the chemical activity of the components increases with a decrease in the particle size.
Specifications Grading at Scale: Improved Letter Grades and Grading-Related Interactions in a Course with over 1,000 Students
Authors: McKnelly Kate J. , Howitz William J. , Thane Taylor A. , Link Renée D.
Published: April 2023

In our previous work we piloted a specifications grading system in an organic chemistry laboratory course with 37 students. Our current work describes the scale up of that specifications grading system to a course with over 1,000 students. Strategies used for keeping the system manageable and mitigating the time commitment required to do so are described. We found that the time necessary to grade student work and manage the specifications grading implementation of the course was not any greater than for the previous, points-based course, that grade-related interactions were more positive, and that student letter grades increased. Despite the increase in final letter grades, we encountered some resistance to the grading system from students and graduate teaching assistants. Here, we explore their concerns and address the difficulty of alternative grading methods in overcoming habituation to traditional points-based grading systems. Future work is needed to evaluate student and graduate teaching assistant buy-in, to assess potential improvement in student work, and to address questions regarding equity in specifications grading systems.
Chloromethyl boryl-N-tosylhydrazone as a versatile synthetic building block
Authors: Miyazaki Ryuya , Muto Kei , Yamaguchi Junichiro
Published: April 2023

Chloromethylboryl-N-tosylhydrazone (CMBT) has been synthesized as a reagent to generate a diverse range of molecular skeletons. CMBT can undergo a series of transformations involving nucleophilic substitution of the chloride, coupling of the N-tosylhydrazones, follwed by boryl group functionalization. We further demonstrated that this CMBT reagent could enable a diverisity-oriented synthesis.
Unraveling the Structural and Property Differences Between Highly Similar Chiral and Racemic Crystals Composed of Analogous Molecules
Authors: Ishizaki Kazuki , Takagi Daisuke , Asahi Toru , Kuramochi Masahiro , Taniguchi Takuya
Published: April 2023

The structural differences between chiral and racemic crystals of enantiomers have piqued interest, as exemplified by the classical Wallach's rule. However, the mechanical and thermal disparities between these materials have not been thoroughly investigated. This study reports the structural and mechanical differences between chiral and racemic crystals of two analogous molecules. The similarity of molecular and crystal structures between the two analogs was validated through comparison with known chiral-racemic crystal pairs. The Young's moduli of the four crystals revealed larger values for racemic crystals than their chiral counterparts, consistent with the intermolecular interaction energies projected along the loading direction. The thermal response of crystals plays a significant role in their elastic behavior, and the temperature dependence of interaction energies along [001] direction was found to agree with the temperature dependence of lattice dynamics for all four crystals.
Mechanistic Studies on on Rh-Catalyzed Ligand-Controlled Chemoselective Hydrothiolation of Cyclopropenes
Authors: Tang Dingyi , Chen Zhizheng , Su Xiaoxi , Qu Shuanglin
Published: April 2023

Recently, it has been reported that Rh-catalyzed ligand-controlled hydrothiolation of cyclopropenes leads to cyclopropyl or allylic sulfides with high regiocontrol. However, there has yet to be any previous research investigating the detailed mechanism of this reaction. Therefore, density functional theory calculations were performed to provide mechanistic insight into the hydrothiolation of cyclopropenes. The study results show that when L5 is the ligand, cyclopropyl sulfide 3 is the main product, and reductive elimination is the rate-determining step. However, allylic sulfide 4 becomes the primary product when L8 is employed. The reaction follows the carbene formation pathway instead of the initially proposed cyclopropene π bond activation pathway. The chemoselectivity is determined by the competition with Rh−Cγ insertion and reductive elimination. When L5 as the ligand, the origin of the chemoselectivity can be attributed to the electronic effect, steric hindrance effect, and C–H…π interaction. Additionally, the distortion/interaction analysis shows that the allylic sulfide originated predominantly due to the lower distortion energy of the substrate fragment in the reductive elimination transition state under the L8 ligand.
Unraveling the Phase Behavior, Mechanical Stability, and Protein Reconstitution Properties of Polymer-Lipid Hybrid Vesicles
Authors: Muller Wagner , Beales Paul , Muniz André , Jeuken Lars
Published: April 2023

Hybrid vesicles consisting of natural phospholipids and synthetic amphiphilic copoly- mers have shown remarkable material properties and potential for biotechnology, com- bining the robustness of polymers with the biocompatibility of phospholipid mem- branes. To predict and optimize the mixing behavior of lipids and copolymers, as well as understand the interaction between the hybrid membrane and macromolecules like membrane proteins, a comprehensive understanding at the molecular level is essen- tial. This can be achieved by a combination of molecular dynamics simulations and experiments. Here, simulations of POPC and PBd22-b-PEO14 hybrid membranes are shown, uncovering different copolymer configurations depending on the polymer-to- lipid ratio. High polymer concentrations created thicker membranes with an extended polymer conformation, while high lipid content led to the collapse of the polymer chain. High concentration of polymer further correlated with a decreased area com- pression modulus and altered lateral pressure profiles, hypothesized to result in the experimentally-observed improvement in membrane protein reconstitution and resis- tance towards destabilization by detergents. Finally, simulations of a WALP peptide embedded in the bilayer showed that only membranes with up to 50% polymer con- tent favored a transmembrane configuration. These simulations correlate with previous and new experimental results and provide a deeper understanding of the properties of lipid-copolymer hybrid membranes.
A pilot study of the intrauterine non-ablative erbium laser effectiveness in the endometrium preparation for cryopreserved embryo transfer in women with a history of implantation failures
Authors: Pustotina Olga A. , Gashenko Anfisa A. , Ustinova Elena I. , Lishova Ekaterina A. , Lopatina Anna V. , Techiieva Zhanna S. , Vizintin Zdenko
Published: April 2023

Background. Embryo implantation failure remains an urgent issue of assisted reproductive technologies (ART).
Aim. To determine the effect of intrauterine irradiation with a non-ablative erbium laser on the endometrium state using the histological and immunohistochemical examination and to evaluate its effectiveness in ART cryo-protocols.
Materials and methods. The study enrolled 25 women aged 2645 with 1 to 5 failed implantations who were planning a pregnancy in a cryopreserved embryo transfer protocol. On days 610 of the menstrual cycle, all patients underwent a single procedure of intrauterine irradiation of the endometrium and cervical canal mucosa with an erbium laser in a non-ablative mode using Fotona SP Dynamis laser system (Slovenia). The histological and immunohistochemical data of the endometrium before and 12 months after the procedure and the pregnancy rate with subsequent transfer of the cryopreserved embryo were assessed.
Results. Intrauterine irradiation with a non-ablative erbium laser increased the proliferative activity of the endometrium (p=0.029), the expression of vascular endothelial growth factor (p=0.029), reduced the sclerosis lesions in the spiral arteries and endometrial stroma, increased the expression of progesterone and estrogen receptors, thus significantly increasing the effectiveness of the ART cryo-protocols (p=0.013).
Effect of Incentive Spirometry in Subjects with Snoring
Authors: Rana Amar , Aaron Pravin
Published: April 2023

Introduction Snoring is the vibratory sound generated from the upper airway due to partial upper airway obstruction resulting from narrowing that occurs during sleep. Snoring if not addressed leads to obstructive sleep apnea which thereby increases the risk of cardiovascular diseases.Objective To evaluate the effect of incentive spirometry in subjects with snoring.Materials and Method Thirty subjects both male and female with snoring within age group of 20 to 60 years performed incentive spirometry exercise with 10 repetitions four times a day for four weeks. The outcome measures overnight recording of pulse oximeter and SOS Snore Outcome Survey questionnaire were recorded at the start and the end of the entire session.Result Paired t-test t1.425 was carried out to compare the mean and SDs of pre-test and post-test scores and were found to be non-significant pgt0.05. Wilcoxon test z4.065 was carried out to compare the mean and standard deviations of pre-test and post-test scores which was found to be highly significant plt0.001.Conclusion This study concluded that the effect of incentive spirometry in subjects with snoring was not statistically significant but clinically significant. In subjects with less severe snoring no significant effects were noticed in the overnight oxygen saturation. However the patient reported outcome measure i.e. SOS questionnaire showed significant improvement after the practice of incentive spirometry exercise for four weeks.
FEATURES OF DIRECT DEMOCRACY IN SWITZERLAND: POLITICAL AND LEGAL ANALYSIS
Authors: Denysiuk Svitlana
Published: April 2023

The tools of realization of direct democracy in Switzerland are considered. The Swiss political system, levels of government and distribution of powers between institutions are analyzed. Emphasis is placed on the fact that direct democracy allows the population to directly influence important decisions at all levels. Swiss citizens have the opportunity to vote on their own through a popular initiative and a referendum, which is optional and mandatory. The historical principles of development of instruments of direct democracy are considered.

Assumptions are made about possible risks and shortcomings in the process of implementing direct democracy. The point is that extreme right-wing forces may abuse the instruments of democracy to amend existing legislation. The goal is to promote politicians' own interests. With the help of political technologies, in particular the use of populist slogans, inaccurate statistics and false facts, the leaders of radical parties manipulate the opinion of citizens, inciting them to put forward certain projects to national referendums. The assumption is substantiated that the vote of citizens can lead to the tyranny of the majority. Legislation and responsibility of citizens minimize the risk of such a scenario.

The political and legal bases for the use of direct democracy in Switzerland are analyzed.

Comparing the advantages and risks of decision-making with such a system, it is concluded that it is optimal for today. The focus of Switzerland's direct democracy is a compromise dialogue between citizens and the authorities.

The draft law «On Local Referendum» № 5512 was considered. Its purpose is to return to the citizens of Ukraine the constitutional right to independently resolve issues of local significance by the territorial community by direct vote. Suggestions for improving the content of this bill have been formulated. We are talking about: the expediency of dividing referendums into types; analysis of the percentage of turnout when considering issues of local importance, increasing the number of questions for voting, etc. It is noted that in order to successfully use the Swiss experience in Ukrainian society, these proposals require broad discussion with the involvement of political scientists and lawyers, awareness of their own responsibility to politicians and the public.
The effects of tempe protein isolate from non-germinated and germinated
soybean on oxidative stress in diabetic rats
Authors: Rachmawati N.A. , Astawan M. , Wresdiyati T. , Yoshari R.M.
Published: April 2023

Diabetes mellitus (DM) patients tend to be more susceptible to the COVID-19 virus.
Evidence suggests that infection with the COVID-19 virus leads to increase reactive
oxygen species (ROS) production. Moreover, hyperglycaemic conditions also produce
excess ROS. Those can lead to oxidative stress in DM patients. This study aimed to
prevent oxidative stress by using innovative functional food called tempe protein isolates,
which were isolated from both non-germinated soybean (TPIN) and germinated soybeans
(TPIG). TPIN, TPIG and commercial soy protein isolate (CSPI) were given 900 mg/kg
BW to DM rats for 28 days. The DM rats were modelled by inducing an alloxan dose of
110 mg/kg BW intraperitoneally. Results showed there were no significant differences
(p>0.05) in feed intake and blood profile. TPIN significantly prevented excessive weight
loss and reduced blood glucose (p<0.05) better than TPIG and CSPI. TPIN and TPIG
significantly (p<0.05) prevent the formation of MDA in the kidney, increase the activity
of the SOD enzyme in both liver and kidney tissues and increase Cu,Zn-SOD antioxidant.
This study concluded that the administration of TPIG and TPIN could prevent liver and
kidney tissue damage by free radicals. Furthermore, TPIN has better potential than TPIG
to prevent oxidative stress.
Amylase, protease, and lipase-producing microbes of local origin as potential
starter cultures for low-salt moromi fermentation
Authors: Devanthi P.V.P. , Wardhana Y.R. , Pratiwi G. , Surjawan I.
Published: April 2023

High salt concentration (18%-22% NaCl) is essential for halophilic microbes to grow and
develop aroma during soy sauce fermentation. Due to health concerns, recent efforts have
focused on reducing salt during fermentation by introducing novel yeast species.
However, the natural fermentation of soy sauce involves a more complex microbial
community essential for achieving optimal sensory qualities. This study aimed to select
potential bacterial and fungal species from traditional soy sauce factories in Indonesia for
use in low-salt fermentation. Isolates that showed positive enzymatic activities at 20%, as
well as 5% NaCl, were subjected to growth profile characterisation in tryptic soy broth
(TSB) with different salt concentrations (0%, 5%, and 20%) and pH (4.0, 5.0, and 6.0). A
total of 47 bacterial and 39 fungal isolates were obtained. Fourteen bacterial and 12 fungal
isolates demonstrated positive enzymatic activities at 20% and 5% NaCl. The majority of
bacterial strains were identified as Bacillus subtilis, while most of the fungal isolates
belonged to the Aspergillus genus (Aspergillus oryzae and Aspergillus tamarii). The
majority of Bacillus isolates performed rapid growth in 5% NaCl and relatively low pH
(5.0), indicating their potential application in low-salt soy sauce production.
The production process of tempe protein isolate from germinated soybeans and
its potential as an antidiabetic
Authors: Yoshari R.M. , Astawan M. , Prangdimurti E. , Wresdiyati T.
Published: April 2023

Physical activity limitations during the COVID-19 pandemic have the potential to be a
community-wide risk factor for type 2 diabetic mellitus (DM). Tempe, an indigenous
Indonesian food, can be developed into protein isolate for DM treatment. The protein
isolates that were used in this study were tempe protein isolate from germinated soybeans
(GTPI), tempe protein isolate from non-germinated soybeans (NGTPI), and commercial
soybean protein isolate (CSPI) as a control. This study aimed to evaluate the effect of the
soybean germination process on the production of tempe protein isolate (TPI) and
antidiabetic potency of TPI by assessing amino acid composition, aglycone isoflavone
level, and in vivo hypoglycaemic assays. The results showed that the production of GTPI
requires a higher extraction pH (11.6-12.6) and a lower pI (3.6-4.2) than the manufacture
of NGTPI. In vivo tests showed that GTPI has a better hypoglycaemic ability than NGTPI
and CSPI. The hypoglycaemic ability of GTPI is supported by the higher content of
arginine and isoflavone aglycones (daidzein and genistein) in GTPI compared to NGTPI
and CSPI. These findings indicated that the germination process might increase bioactive
compounds in soybean, which had a strong association with tempe protein isolate's
antidiabetic effectiveness.
Promoting the Personal Development of Children Through Art Education
Authors: Zheng Yang
Published: April 2023

With the arrival of the new era, the development of society changes with each passing day, innovative ability and creative thinking skills are increasingly valued by society. The development of innovative ability should start with children. The emergence of new educational concepts requires the school to cultivate students in a comprehensive way. In this case, art and music, which were once considered unimportant, are gradually changing the educational field and are returning to the public eye. Studies have shown that art education plays an important role in promoting personal development of children. Therefore, art education should not be neglected, and we should see that art education plays a certain role in improving children’s innovative abilities. However, there are still many problems in art education for children, which affects its role in promoting their personal development. Therefore, it is important to focus on how to promote children’s personal development through art education. This paper analyzes the problems faced in children’s art education and how to effectively maximize its role of art education to promote the development of children’s art education.
Private Equity Investment: Friend or Foe to Applied Behavior Analysis
Authors: Litvak Sara Gershfeld
Published: April 2023

Private equity firms are increasingly investing in U.S. healthcare, specifically applied behavior analysis. Although supporters argue it can increase innovation, access-to-care, and reimbursement rates, critics say that it can harm clinical practices and reduce the quality of care. Healthcare regulations and laws prevent private equity firms from harming patients to earn a profit, however, quality care is required beyond just the safety of a patient. This paper explores the dynamics emerging from the entry of private equity, the potential concerns, and benefits, and provides some suggestions to mitigate potential drawbacks.
The results of evaluation of adaptability of corn parental lines
Authors: Gorbacheva Anna Grigorievna , Orlyanskaya Natalya Alekseevna , Vetoshkina Irina Anatolievna , Chebotarev Dmitry Sergeevich
Published: April 2023

Information about the adaptability of corn parental lines helps to optimize hybrid seed production. The purpose of this article is to evaluate the plasticity and stability parameters of nine corn inbreds that were used to produce new hybrids. We conducted the research in 2019-2021 in two areas which include the foothill of the North Caucasus (Pyatigorsk) and the forest-steppe of the Central Black Earth Region (Voronezh). There were diverse environments in the areas: nonlimiting conditions were in Voronezh in 2019 (Ij=1.75) and 2020 (Ij=0.02) and limiting conditions were in Voronezh in 2021 (Ij=-1.07) and in Pyatigorsk in 2019-2021 (Ij=-0.03…-0.38). The most prevailing factor which influenced corn grain yield was the environmental conditions (50.13%) but genotype (25.60%) and GEI (21.16%) were less influential. We found a significant variation in the inbred grain yield across the years (22.0–47.2%). The research shows that the KL 6, RGS 201, RG 218 and RG 266 lines had high coefficients of adaptability (Ka=1.04–1.40) in diverse environments. The KL 6 and RG 218 lines had high adaptable potential according to a ranking system (sum of ranks 6.4 and 6.7) and we recommended them for breeding programs to develop adaptable corn hybrids. It is better to grow the KL 6, RGS 201, RG 218 and RG 266 lines in a wide range of environments. The RS 201, DA 27-11 and AG 1712 lines are suitable for nonlimiting conditions and the RV 197 and RG 297 lines can be grown in unfavorable conditions.
Increased activity of the pro/antioxidant system of potato microplants by rhizospheric bacterias in aeroponics conditions
Authors: Tkachenko Oksana Viktorovna , Evseeva Nina Vasilievna , Kargapolova Kristina Yurievna , Denisova Alena Yurievna , Pozdnyakova Natalia Nikolaevna , Kulikov Artem Aleksandrovich , Burygin Gennady Leonidovich
Published: April 2023

The improvement of plants in in vitro culture is an obligatory stage of potato seed production. Plant-growth-promoting rhizobacteria contribute to an increase in plant resistance to stress factors, including at the stage of adaptation of microplants to ex vitro conditions. The purpose of this investigation was to study the mechanisms of antioxidant protection of potato microclones during inoculation with rhizobacteria in the process of their adaptation to ex vitro conditions in an aeroponic installation. In experiments, microplants of potato Nevsky and Condor cultivars inoculated in vitro with rhizobacteria Azospirillum baldaniorum Sp245 and Ochrobactrum cytisi IPA7 were used. In the process of adaptation in aeroponics conditions, microplants were analyzed for morphometric and biochemical parameters for 21 days. It was found that the bacterization of microplants contributed to the regulation of the pro/antioxidant system, leading to a decrease in oxidative stress and better and faster survival of plants ex vitro.
Theoretical aspects of production of sprinkler nozzles with a rotating deflector
Authors: Rusinov Dmitry Alekseevich , Kravchuk Alexey Vladimirovich , Kolganov Dmitry Aleksandrovich
Published: April 2023

In the materials of the article, the theoretical question of creating sprinkler nozzles with a rotating deflector cone is considered. Mathematical dependences describing the design and technological parameters of the sprinkler nozzle are presented. The process of raindrops falling created by a rotating deflector cone is considered. The results of laboratory studies are presented, during which it was proved that the irrigation radius increased by an average of 25.2% with a rain nozzle having a rotating deflector cone compared with a smooth non-rotating deflector cone. This will allow the sprinkler nozzles to be installed on the sprinkler machine pipeline at a greater distance from each other, which will reduce the cost of the sprinkler machine.
Critical Race Theory and Mixed Methods in Educational Research: A Scoping Review
Authors: Bagwell Dawn , Hall Nicole R. , Worsley Ti’Era , Neblett Debra A.
Published: April 2023

As educational researchers respond to the current debate around critical race theory (CRT) playing out in legislation across the United States, the debate is challenging mixed methods researchers to imagine new ways of conducting inquiry. In this scoping review, we examine current educational research that uses both a CRT theoretical framework and a mixed methods research (MMR) design to demonstrate the potential that a combined approach must leverage participants’ voices and experiential knowledge to provide more concrete ways in which institutions might challenge dominant ideologies and adopt a more transformative stance. We found that when researchers were able to both purposefully (and indistinguishably) integrate CRT within the MMR design (Hammersley, 2018) and highlight the underlying distinctions between quantitative and qualitative in their methodological choices (Morgan, 2018), they advanced the field by providing richer, more detailed road maps for dismantling systemic inequities. Our findings expose the ways in which well-defined, intentional methodological approaches more fully embrace praxis to foster more equitable outcomes.
PATHOLOGY OF THE URINARY SYSTEM AND ITS FREQUENCY IN CHILDREN WITH COVID-19
Authors: Yarovaya Darya , Bashkina Ol'ga , Krasilova Elena , Samotrueva Marina , Kasymova Ekaterina
Published: April 2023

This review presents data on endothelial dysfunction and the mechanisms of its development in coro-navirus disease. The possible pathology of the urinary system and its frequency in children against the background of COVID-19, which is mainly due to endothelial dysfunction, is described. Displayed studies on the frequency of urinary tract infections in children and adolescents during a pandemic, which depended on the level of quarantine measures, which in turn affect the neuro-psychological causes of bladder dysfunction, limited timely access to medical care, etc. A systematic review of stud-ies published in English from 2000 to 2019 was performed (with predominant inclusion (84,6 %) of data for the last 2 years) using PubMed, ScienceDirect, ProQuest, GoogleScholar, Cochrane, Medline, AMED databases., EMBASE, CINHAL, SportDiscus, Scopus and PEDro. The review included review articles, meta-analyses, qualitative studies, retrospective and prospective studies.
¿Qué impacto tiene el uso de las TIC en el desempeño de empresas de turismo en Nuevo León, México?
Authors: Avilez Pineda María Elena , Chunga Liu Zeidy , Martínez Zúñiga Mirna Guadalupe
Published: April 2023

Se busca demostrar en esta investigación el impacto que el uso de las tecnologías de la información y comunicación tienen sobre el desempeño en las empresas de servicios turísticos en Nuevo León, México, partiendo de las premisas teóricas de García, Díaz y Arias-Pérez, 2017; Díaz y Montenegro, 2010, y Cantero, 2011) entre otros, conforme a una investigación cuantitativa, descriptiva, bajo un diseño de campo, no experimental y transversal. La población la conforman 131 gerentes, a quienes se les administró una encuesta mediante un cuestionario de12 ítems, validado por expertos, la confiabilidad se calculó por el coeficiente de Cronbach. Como resultado del análisis de las preguntas formuladas se tiene que, en opinión de los encuestados, la empresa casi siempre logro un uso adecuado de las tecnologías de la información y comunicación, lo cual es derivado de la situación presentada con la pandemia del COVID-19. Una vez procesados los datos, se procedió a la representación gráfica, entre los que se evidencia que la computación o informática y las redes comunicacionales, presentan similar tendencia pues ambas convergen siendo indispensables para el desempeño. Entre sus conclusiones se destacan: que el uso de las tecnologías de la información y comunicación como herramienta tecnológica en sus componentes, la computación o informática, y redes comunicacionales, casi siempre influyen en el desempeño; los softwares se deben actualizar en la medida que la productividad aumente, esto a fin de ser más competitivas.
Agaricus bisporus Ekstraktı Kullanılarak ZnO Nanopartiküllerinin Yeşil Sentezi: Yapısal Karakterizasyonu ve Biyolojik Aktivitelerinin İncelenmesi
Authors: BEKEM Ravza , DURMUŞ Sefa , DALMAZ Aslıhan , DULGER Gorkem
Published: April 2023

Nanoteknolojinin ilginç yönlerini keşfetmek adına son yıllarda birbirinden farklı birçok çalışma yapılmaktadır. Nanomalzeme üretiminin hızlı gelişimi, çok çeşitli alanlarda metal oksit (ZnO) uygulamalarını da beraberinde getirmiştir. Çinko oksit nanopartikülleri (ZnO NP), ticari kullanım için mekanik veya kimyasal olarak elde edilebilir. Ancak, bu tekniklerin ortaya çıkardığı çevre sorunları bir hayli dikkat çekmiştir. Günümüzde, ZnO NP’nin yeşil sentezi, çevre sorunlarını azaltmayı amaçlayan araştırma alanında özellikle ilgi görmektedir. Bu yeşil yaklaşımda, bitki özü, mikroorganizma, mantar ve alg gibi doğal bazlı malzemeler, biyoaktif fitokimyasallardaki zenginleşmeleri nedeniyle biyo-indirgeyici ve biyo-stabilizatör olarak kullanılmaktadır. Bu çalışmada, ZnO NP farklı çinko tuzları ile doğal bir ürün olan mantar ekstraktı (Agaricus bisporus) kullanılarak sentezlenmiştir. Elde edilen ZnO NP X-ışını kırınımı (XRD), Fourier dönüşümü kızılötesi spektroskopisi (FT-IR), Taramalı elektron mikroskobu (SEM) analizi, Enerji dağılımlı X-ışını analizi (EDX) ile karakterize edildi. Son olarak ZnO NP’nin bakteri ve funguslara karşı antimikrobiyal aktiviteleri kuyu difüzyon yöntemi ile ölçülerek sonuçlar kaydedildi.
Sulu Çözeltilerden Pb2+ İyonlarının Uzaklaştırılmasında Atık Portakal Kabuklarının Kullanılması: Kinetik ve Termodinamik Çalışmalar
Authors: ALTUNKAYNAK Yalçın , CANPOLAT Mutlu , YAVUZ Ömer
Published: April 2023

Bu çalışmada, Pb2+ iyonlarının sulu çözeltilerden uzaklaştırılmasında atık portakal kabuğunun (APK) etkin bir şekilde değerlendirilmesi ve geri dönüşüme kazandırılması anlatılmaktadır. Adsorpsiyon verimliliği için; metal iyonu başlangıç derişimi, temas süresi, pH etkisi gibi farklı parametrelerin sonuçları incelendi. Pb2+ iyonunun uzaklaştırılmasında en uygun çalışma koşulları; metal iyonu başlangıç derişimi 800 mg/L, temas süresi 90 dakika ve çözelti pH'ı 4,32 olarak belirlendi. APK’nın yüzey özellikleri, Fourier dönüşümlü kızılötesi spektroskopisi (FTIR), taramalı elektron mikroskobu (SEM) ve enerji dağılım spektroskopisi ile araştırıldı. Elde edilen veriler (izoterm verileri) incelendiğinde, işlemin olası tersinmezliğine ve kimyasal adsorpsiyona karşılık gelen Langmuir izoterm modeline uygun olduğunu gösterdi. 298, 308 ve 318 K'de Pb2+ iyonu için adsorpsiyon kapasitesi sırasıyla 35,842, 35,714 ve 35,087 mg/g olarak hesaplandı. En iyi kinetik veriler, Pb2+ adsorpsiyonu için en yüksek regresyon katsayısına sahip yalancı ikinci dereceden denklem ile tanımlandı. Termodinamik çalışmalar, APK kullanılarak Pb2+ iyonlarının uzaklaştırılması işleminin doğal ve endotermik bir süreç olduğunu gösterdi. APK 'nın yüksek uzaklaştırma kapasitesi, kolay bulunması ve ucuz olması nedeniyle sulu ortamdan Pb2+ iyonlarının uzaklaştırılmasında etkili ve umut verici bir malzeme olduğu tespit edildi.
A New Greedy Algorithm for the Curriculum-based Course Timetabling Problem
Authors: COŞAR Batuhan Mustafa , SAY Bilge , DÖKEROĞLU Tansel
Published: April 2023

This study describes a novel greedy algorithm for optimizing the well-known Curriculum-Based Course Timetabling (CB-CTT) problem. Greedy algorithms are a good alternative to brute-force and evolutionary algorithms, which take a long time to execute in order to find the best solution. Rather than employing a single heuristic, as many greedy algorithms do, we define and apply 120 new heuristics to the same problem instance. To assign courses to available rooms, our proposed greedy algorithm employs the Largest-First, Smallest-First, Best-Fit, Average-weight first, and Highest Unavailable course-first heuristics. Extensive experiments are carried out on 21 problem instances from the benchmark set of the Second International Timetabling Competition (ITC-2007). For 18 problems with significantly reduced soft-constraint values, the proposed greedy algorithm can report zero hard constraint violations (feasible solutions). The proposed algorithm outperforms state-of-the-art greedy heuristics in terms of performance.
Gömülü sistemlerde kaotik haritalar kullanılarak gerçek zamanlı görüntü şifreleme uygulaması
Authors: CANDAN Cagri , ŞAHİN Muhammet Emin
Published: April 2023

Teknolojinin ilerlemesi, multimedya ve iletişim araçlarının genişlemesinde veri aktarımı sürecini hızlandırmaktadır. Dijital görüntüler, veri aktarımlarında en sık kullanılan veri türlerinden biridir. Bu görüntüler kişisel ve gizli bilgiler içerebilir. Görüntülerin genel bir ağ üzerinden gönderildiğinde, alıcı tarafa şifreli olarak iletilmesi bilgi güvenliği açısından çok önemlidir. Kaos tabanlı yöntemler en yaygın olarak kullanılan görüntü şifreleme teknikleridir. Bu çalışmada, Henon ve Tent kaotik haritaları kullanılarak Jetson Tx2 ve Jetson Nano gömülü sistemler üzerinde gerçek zamanlı olarak karıştırma ve yayılma tabanlı bir görüntü şifreleme yöntemi tasarlanmış ve uygulanmıştır. Uygulanan görüntü şifreleme sisteminin performansını değerlendirmek için literatürde en sık kullanılan yöntemler histogram analizi, korelasyon analizi ve anahtar duyarlılık analizi gibi güvenlik testlerine tabi tutulmaktadır. Ayrıca önerilen sistem, iki farklı gömülü sistemin şifreleme ve şifre çözme süreleri karşılaştırılarak değerlendirilmiştir. Sonuçlar, önerilen görüntü şifreleme sisteminin oldukça güvenli olduğunu açıkça göstermektedir.
The Path of the Internal Public Debt and its Potential to Influence the Money Supply Iraq Case Study for the Period (2016-2020)
Authors: Eyal Alaa Kadhem , Al-Khikani Nazar Kadhem , Mohammed Aliya Jassam
Published: April 2023

This research focuses on the effects of the internal public debt, whether direct or indirect, in Iraq, and in view of the rentierism that characterizes the Iraqi economy, and in financial crises, especially when prices drop, it remains interested in its budgets to finance the increasing public spending through the internal public debt ,The greater the size of that debt, the greater the public spending, and the role of the internal public debt in the money supply in Iraq comes through the government financing the public budget deficit through some internal public debt instruments, especially bonds and treasury transfers. The researchers reached the existence of such a relationship in Iraq, but it was in a state of fluctuation, due to the presence of other variables that prevent it, and to achieve the goals sought by the researchers, the research included three sections, the first focused on a review of the most important concepts for the research variables, and the second was about analyzing Those variables, and in the last section included an analysis of the relationship between the internal debt instruments and the money supply in Iraq for the period (2016-2020).
Pengembangan Lembar Kerja Peserta Didik (LKPD) Berbasis POE (Predict Observe Explain) Pada Mata Pelajaran IPS di SDN 2 Lendang Kunyit
Authors: Aulia Nurul , Tahir Muhammad , Indraswati Dyah
Published: April 2023

Pendidikan tidak terlepas dari kegiatan belajar mengajar di sekolah yang membutuhkan metode pembelajaran yang efektif serta perangkat pembelajaran yang inovatif. LKPD adalah salah satu dari perangkat pembelajaran yang yang harus dipegang guru pada kegiatan belajar mengajar. Penelitian ini bertujuan untuk menghasilkan suatu produk Lembar Kerja Peserta Didik (LKPD) berbasis POE (Predict Observe Explain) yang telah diuji kelayakannya dan mengetahui bagaimana respon siswa terhadap produk tersebut. Penelitian ini menggunakan jenis pendekatan penelitian dan pengembangan (R&D) model ADDIE, metode pengumpulan data yaitu wawancara dan angket yang terdiri dari angket validasi ahli media dan ahli materi serta angket respon peserta didik. Teknis analisis data menggunakan deskriptif kuantitatif. Subyek dalam penelitian ini adalah peserta didik kelas IV SDN 2 Lendang Kunyit dan objek penelitian adlah LKPD berbasis POE. Hasil penelitian menunjukkan bahwa kelayakan LKPD dari ahli media adalah 84% dan kelayakan dari ahli materi adalah 86% serta hasil respon peserta didik pada kelompok kecil adalah 90 % dan kelompok besar 92%. Hasil ini didapatkan melalui angket validasi ahli materi dan ahli media serta angket respon peserta didik.
PERCEPÇÕES SOBRE A TERRA PRETA INDÍGENA NO SÍTIO ARQUEOLÓGICO DONZA, RO.
Authors: Gomes Zelília Almeida
Published: April 2023

Este estudo monográfico teve como objetivo dar visibilidade aos remanescentes indígenas relacionados aos dois locais de coleta de sedimento (unidade e perfil do barranco), no Sítio arqueológico Donza (sítio com presença de terra preta arqueológica), localizado nas margens do Rio Madeira, Porto Velho, Brasil, a partir da metodologia de flotação. Os dois locais destacados foram selecionados para flotação a fim de analisar quantitativamente e qualitativamente o material arqueológico encontrado junto ao sedimento coletado (em campo), visando a identificação, quantificação e verificação da presença de materiais arqueológicos, relacionando-os aos níveis arqueológicos e camadas escavadas in situ, associando os resultados das análises das evidências do solo (flotação) nos dois locais.
APLICAÇÃO DAS TÉCNICAS DA BIOLOGIA MOLECULAR COMO MÉTODO DE DIAGNÓSTICO DAS DERMATOFITOSES: REVISÃO DE LITERATURA
Authors: BEZERRA FELIPE GONÇALVES , SANTANA LARAH DOMINGOS ALVES , SANTOS AMANDA DE OLIVEIRA
Published: April 2023

OBJETIVO: O atual estudo, propôs descrever, por meio de um levantamento bibliográfico de revisão literatura, aplicar técnicas da biologia molecular como método de diagnóstico das dermatofitoses. METODOLOGIA: Para tanto, as informações foram obtidas na seleção de artigos dos últimos 5 anos. O instrumento utilizado para coleta de dados incluiu-se a utilização de consulta na base de dados do Bireme, PubMed e Scielo nos idiomas português e inglês de forma gratuita. RESULTADOS E DISCUSSÃO: Os resultados aqui descritos, evidenciaram três técnicas moleculares (PCR, PCR-RFLP e Multiplex PCR) que foram utilizadas em combinação com as técnicas convencionais na identificação de dermatófitos, e que, cada uma delas, apresentaram ser mais sensíveis, específicas e rápidas em comparação as técnicas usadas na rotina laboratorial. CONCLUSÃO: Nesse sentido, conclui-se que as técnicas da biologia molecular, podem ser um meio mais preciso no diagnóstico das dermatofitoses.

Palavras-chave: Dermartomicoses; Infecção por Dermatófitos; Técnicas de Diagnóstico Molecular.
DIAGNÓSTICO E TERAPÊUTICA FRENTE A LUXAÇÃO DA ATM
Authors: BARBOSA MAYARA MARTINS , MELO ANDRÉS MIRANDA MACHADO DE , MOREIRA CARLOS LEONE FARIA , MARTINS SABRINA FERNANDES , URBANO EDUARDO STEHLING
Published: April 2023

A luxação da articulação temporomandibular (ATM) ocorre quando o côndilo da mandíbula se desloca da fossa glenóide e falha ao retornar à sua posição anatômica original. Esse evento pode ser recorrente ou acontecer de forma espontânea, é indicada como recidivante quando pelo menos três episódios consecutivos acontecem em um período de até seis meses. Clinicamente, a luxação da ATM apresenta-se como dificuldade de fechar a boca, sialorréia, tensão nos músculos mastigatórios e muita dor na região da articulação. A etiologia da luxação da ATM é multifatorial, podendo incluir: cavidade glenóide pouco profunda, frouxidão do ligamento temporomandibular ou da cápsula articular e excessiva atividade do músculo pterigóideo lateral e dos músculos infra-hioídeos devido uso de medicamentos ou alguma patologia. A presença de um ou mais desses fatores somados ao simples ato de bocejar, rir, falar ou comer podem desencadear em um processo de luxação e comprometer o bem-estar do indivíduo. O objetivo do presente trabalho é relatar o processo diagnóstico e terapêutico no tratamento da luxação da ATM. Diante disso, foi realizada uma pesquisa nas bases de dados: SciELO, Biblioteca Regional em Saúde (BVS), Periódicos Capes e Google Acadêmico e 14 artigos foram selecionados a partir dos critérios de inclusão e exclusão. O diagnóstico é essencial para elaboração de um tratamento ideal para cada caso. Um paciente que sofre um episódio de luxação tende a apresentar principalmente dificuldade de abrir a boca, deflexão e sialorréia. O tratamento irá depender das características clínicas do paciente e pode incluir tratamentos não invasivos e a redução manual ou tratamentos cirúrgicos. O tratamento não invasivo é sempre o primeiro a ser indicado e a Hemartrocentese é a primeira escolha por possuir bons resultados, mas também pode ser utilizado a injeção de toxina botulínica no pterigóideo lateral e a injeção de agentes esclerosantes. O tratamento cirúrgico é em último caso e a Eminectomia é a cirurgia com melhores resultados.
Palavras-chave: Articulação temporomandibular; Luxação; Terapia; Diagnóstico.
SÍNDROME DE BURNOUT EM ENFERMEIRAS QUE TRABALHAM EM UNIDADES DE TERAPIA INTENSIVA: REVISÃO INTEGRATIVA
Authors: SANTOS NAYANE GOMES MOURA , OLIVEIRA LAVÍNIA DOS SANTOS , BELENS MAÍRA DE JESUS , SILVA ELAINE DA CONCEIÇÃO CHAGAS , BANDEIRA ANNY KAROLINY DAS CHAGAS , ABREU PAULO DE TÁSSIO COSTA DE , SOUZA SIMONE SANTOS
Published: April 2023

A síndrome de Burnout (SB) é conceituada como a síndrome do esgotamento profissional, que é um distúrbio psíquico causado pela exaustão extrema relacionada ao trabalho, e está diretamente ligada ao acúmulo de estresse, a tensão emocional e de trabalho. Este trabalho possui como objetivo: descrever a partir da literatura, como a Síndrome de Burnout afeta as enfermeiras que atuam em unidades de terapia intensiva. Metodologia: Revisão integrativa da literatura, a coleta de dados ocorreu em agosto de 2022, através do Banco de Dados da Biblioteca Virtual em Saúde (BVS), no recorte temporal entre os anos de 2017 a 2022, com os seguintes critérios de inclusão: artigos completos, disponíveis gratuitamente em português, totalizando o corpus de 5 publicações. Resultados e discussão: Os artigos encontrados responderam à pergunta de pesquisa e favoreceu o conhecimento quanto a Síndrome de Burnout que afeta as enfermeiras que atuam em unidades de terapia intensiva. Os resultados principais foram sobre os fatores associados a prevalência de enfermeiros com SB como altos níveis de exaustão emocional, baixo nível de realização profissional; alguns fatores sociodemográficos; condições de trabalho na Unidade de Terapia Intensiva (UTI); efeitos da atuação na linha de frente da COVID-19 na saúde mental de enfermeiras. Considerações finais: A maioria dos achados salientaram que a SB é decorrente dos transtornos mentais que se iniciam de forma peculiar, a partir da exaustão da sobrecarga de trabalho. Destacou-se que a enfermeira tem sido alvo da SB no setor de UTI devido a fatores de cunho estressor que favorecem o adoecimento decorrente do labor. Algumas nuances foram destacadas como as questões do exercício profissional durante os adventos da pandemia, com o favorecimento dos sintomas estressores e o desenvolvimento da SB através do cansaço físico e mental excessivo, que influenciaram na qualidade de vida e na saúde física e mental destas profissionais.

Palavras-chave: Enfermagem; Esgotamento profissional; Unidades de terapia intensiva.