bluuebunny/crossref_metadata_2025 huggingface dataset:
Transferable neuronal mini-cultures to accelerate screening in primary and induced pluripotent stem cell-derived neurons
Authors: Niedringhaus Mark , Dumitru Raluca , Mabb Angela M. , Wang Yuli , Philpot Benjamin D. , Allbritton Nancy L. , Taylor Anne Marion
Published: February 2015

The effort and cost of obtaining neurons for large-scale screens has limited drug discovery in neuroscience. To overcome these obstacles, we fabricated arrays of releasable polystyrene micro-rafts to generate thousands of uniform, mobile neuron mini-cultures. These mini-cultures sustain synaptically-active neurons which can be easily transferred, thus increasing screening throughput by >30-fold. Compared to conventional methods, micro-raft cultures exhibited significantly improved neuronal viability and sample-to-sample consistency. We validated the screening utility of these mini-cultures for both mouse neurons and human induced pluripotent stem cell-derived neurons by successfully detecting disease-related defects in synaptic transmission and identifying candidate small molecule therapeutics. This affordable high-throughput approach has the potential to transform drug discovery in neuroscience.
Prion Amplification and Hierarchical Bayesian Modeling Refine Detection of Prion Infection
Authors: Wyckoff A. Christy , Galloway Nathan , Meyerett-Reid Crystal , Powers Jenny , Spraker Terry , Monello Ryan J. , Pulford Bruce , Wild Margaret , Antolin Michael , VerCauteren Kurt , Zabel Mark
Published: February 2015

Prions are unique infectious agents that replicate without a genome and cause neurodegenerative diseases that include chronic wasting disease (CWD) of cervids. Immunohistochemistry (IHC) is currently considered the gold standard for diagnosis of a prion infection but may be insensitive to early or sub-clinical CWD that are important to understanding CWD transmission and ecology. We assessed the potential of serial protein misfolding cyclic amplification (sPMCA) to improve detection of CWD prior to the onset of clinical signs. We analyzed tissue samples from free-ranging Rocky Mountain elk (Cervus elaphus nelsoni) and used hierarchical Bayesian analysis to estimate the specificity and sensitivity of IHC and sPMCA conditional on simultaneously estimated disease states. Sensitivity estimates were higher for sPMCA (99.51%, credible interval (CI) 97.15–100%) than IHC of obex (brain stem, 76.56%, CI 57.00–91.46%) or retropharyngeal lymph node (90.06%, CI 74.13–98.70%) tissues, or both (98.99%, CI 90.01–100%). Our hierarchical Bayesian model predicts the prevalence of prion infection in this elk population to be 18.90% (CI 15.50–32.72%), compared to previous estimates of 12.90%. Our data reveal a previously unidentified sub-clinical prion-positive portion of the elk population that could represent silent carriers capable of significantly impacting CWD ecology.
Fast Super-Resolution Imaging with Ultra-High Labeling Density Achieved by Joint Tagging Super-Resolution Optical Fluctuation Imaging
Authors: Zeng Zhiping , Chen Xuanze , Wang Hening , Huang Ning , Shan Chunyan , Zhang Hao , Teng Junlin , Xi Peng
Published: February 2015

Previous stochastic localization-based super-resolution techniques are largely limited by the labeling density and the fidelity to the morphology of specimen. We report on an optical super-resolution imaging scheme implementing joint tagging using multiple fluorescent blinking dyes associated with super-resolution optical fluctuation imaging (JT-SOFI), achieving ultra-high labeling density super-resolution imaging. To demonstrate the feasibility of JT-SOFI, quantum dots with different emission spectra were jointly labeled to the tubulin in COS7 cells, creating ultra-high density labeling. After analyzing and combining the fluorescence intermittency images emanating from spectrally resolved quantum dots, the microtubule networks are capable of being investigated with high fidelity and remarkably enhanced contrast at sub-diffraction resolution. The spectral separation also significantly decreased the frame number required for SOFI, enabling fast super-resolution microscopy through simultaneous data acquisition. As the joint-tagging scheme can decrease the labeling density in each spectral channel, thereby bring it closer to single-molecule state, we can faithfully reconstruct the continuous microtubule structure with high resolution through collection of only 100 frames per channel. The improved continuity of the microtubule structure is quantitatively validated with image skeletonization, thus demonstrating the advantage of JT-SOFI over other localization-based super-resolution methods.
The molecular architecture of dihydropyrindine receptor/L-type Ca2+ channel complex
Authors: Hu Hongli , Wang Zhao , Wei Risheng , Fan Guizhen , Wang Qiongling , Zhang Kaiming , Yin Chang-Cheng
Published: February 2015

Dihydropyridine receptor (DHPR), an L-type Ca2+ channel complex, plays an essential role in muscle contraction, secretion, integration of synaptic input in neurons and synaptic transmission. The molecular architecture of DHPR complex remains elusive. Here we present a 15-Å resolution cryo-electron microscopy structure of the skeletal DHPR/L-type Ca2+ channel complex. The DHPR has an asymmetrical main body joined by a hook-like extension. The main body is composed of a “trapezoid” and a “tetrahedroid”. Homologous crystal structure docking and site-specific antibody labelling revealed that the α1 and α2 subunits are located in the “trapezoid” and the β subunit is located in the “tetrahedroid”. This structure revealed the molecular architecture of a eukaryotic Ca2+ channel complex. Furthermore, this structure provides structural insights into the key elements of DHPR involved in physical coupling with the RyR/Ca2+ release channel and shed light onto the mechanism of excitation-contraction coupling.
Near-infrared calibration transfer via support vector machine and transfer learning
Authors: Binfeng Yu , Haibo Ji
Published: February 2015

In this study, a new calibration transfer approach using the transfer learning technique is presented.
Oxidative methane activation over yttrium stabilised zirconia
Authors: Cooper C. S. , Oldman R. J. , Catlow C. R. A.
Published: February 2015

Mechanism of C–H bond cleavage, involving electron transfer to adsorbed oxygen on YSZ by electronic structure calculations.
Chiral recognition of Arg based on label-free PET nanochannel
Authors: Sun Zhongyue , Zhang Fan , Zhang Xiaoyan , Tian Demei , Jiang Lei , Li Haibing
Published: February 2015

A label-free nanochannel for enantioselective recognition of d-, l-Arg by adding BSA as chiral selector has been fabricated. Before adding BSA, the nanochannel cannot discriminate d- and l-Arg while with addition of BSA, this nanochannel displayed good enantioselectivity.
Investigation of prototypal MOFs consisting of polyhedral cages with accessible Lewis-acid sites for quinoline synthesis
Authors: Gao Wen-Yang , Leng Kunyue , Cash Lindsay , Chrzanowski Matthew , Stackhouse Chavis A. , Sun Yinyong , Ma Shengqian
Published: February 2015

A series of prototypal metal–organic frameworks (MOFs) consisting of polyhedral cages with accessible Lewis-acid sites, have been systematically investigated for Friedländer annulation reaction.
A reversible two-electron redox system involving a divalent lead species
Authors: Saito Masaichi , Nakada Marisa , Kuwabara Takuya , Minoura Mao
Published: February 2015

A reversible interconversion between Pb(ii) and its dianionic species bearing organic substituents is described.
Decoloration rates of a photomerocyanine dye as a visual probe into hydrogen bonding interactions
Authors: Ciampi Simone , Eggers Paul K. , Haworth Naomi L. , Darwish Nadim , Wagner Pawel , Coote Michelle L. , Wallace Gordon G. , Raston Colin L.
Published: February 2015

A visual marker for probing hydrogen-bonding effects in static and thin film fluidic systems.
Catalytic amounts of CBr4mediated dehydrogenative coupling of isochromans with aromatic ketones
Authors: Huo Congde , Wu Mingxia , Chen Fengjuan , Jia Xiaodong , Yuan Yong , Xie Haisheng
Published: February 2015

In the presence of catalytic amounts of CBr4(a metal-free mediator), an unexpected oxidative dehydrogenative coupling of isochromans with ketones occurred to construct new Csp3–Csp3bonds. The reactions were performed under simple solvent-free aerobic conditions.
Real-time analysis of multiple anion mixtures in aqueous media using a single receptor
Authors: Havel Vaclav , Yawer Mirza Arfan , Sindelar Vladimir
Published: February 2015

Bambusuril macrocycles allow qualitative and quantitative sensing of anion mixtures in water using 1H NMR spectroscopy.
A smart DNA–gold nanoparticle probe for detecting single-base changes on the platform of a quartz crystal microbalance
Authors: Li Hui , Xiao Shiyan , Yao Dongbao , Lam Michael Hon-Wah , Liang Haojun
Published: February 2015

A design of DNA–gold nanoparticle probe-fueled DNA strand displacements for detecting single-base changes on the platform of a quartz crystal microbalance with random sequences was developed.
Frenetic aspects of second order response
Authors: Basu Urna , Krüger Matthias , Lazarescu Alexandre , Maes Christian
Published: February 2015

A theoretical framework to compute the second order response around equilibrium is provided and the importance of the so called frenetic contribution is illustrated.
Unveiling the charge migration mechanism in Na2O2: implications for sodium–air batteries
Authors: Araujo Rafael B. , Chakraborty Sudip , Ahuja Rajeev
Published: February 2015

We systematically investigate the charge transport mechanism in sodium peroxide and explore the impact of charge carrier mobility on Na–O2 cell performance.
On the urea induced hydrophobic collapse of a water soluble polymer
Authors: Rodríguez-Ropero Francisco , van der Vegt Nico F. A.
Published: February 2015

Polymer collapse despite cosolvent binding: solvation of extended coil conformations is entropically penalized, therefore stabilizing compact globular conformations in the coil-globule equilibrium of poly(N-isopropylacrylamide) in aqueous urea solution.
Sailing into uncharted waters: recent advances in the in situ monitoring of catalytic processes in aqueous environments
Authors: Shi Hui , Lercher Johannes A. , Yu Xiao-Ying
Published: February 2015

This review presents recent advances inin situstudies of catalytic processes in the aqueous environment with an outlook of mesoscale imaging.
The role of weak hydrogen and halogen bonding interactions in the assembly of a series of Hg(ii) coordination polymers
Authors: Azhdari Tehrani Alireza , Morsali Ali , Kubicki Maciej
Published: February 2015

A series of eight new Hg(ii) complexes based on the L4-Xligands, where L is (E)-4-halo-N-(pyridin-4-ylmethylene)aniline, were synthesized and characterized and their supramolecular crystal structures were studied by different geometrical and theoretical methods.
Synthesis and characterization of an immobilizable photochemical molecular device for H2-generation
Authors: Braumüller Markus , Schulz Martin , Sorsche Dieter , Pfeffer Michael , Schaub Markus , Popp Jürgen , Park Byung-Wook , Hagfeldt Anders , Dietzek Benjamin , Rau Sven
Published: February 2015

The immobilizable photocatalyst (4) was synthesized and successfully applied in visible-light-driven hydrogen-generation experiments, supporting its applicability in photoelectrosynthesis cells.
Yb7Ni4InGe12: a quaternary compound having mixed valent Yb atoms grown from indium flux
Authors: Subbarao Udumula , Jana Rajkumar , Chondroudi Maria , Balasubramanian Mahalingam , Kanatzidis Mercouri G. , Peter Sebastian C.
Published: February 2015

Yb7Ni4InGe12is a new compound crystallizing from indium metal flux. Magnetic susceptibility and XANES data suggest mixed valent Yb atoms.
Processing of dielectric oxynitride perovskites for powders, ceramics, compacts and thin films
Authors: Masubuchi Y. , Sun S.-K. , Kikkawa S.
Published: February 2015

This perspective reviews recent studies on the fabrication of dielectric oxynitride perovskites for powders, ceramics, compacts and thin films.
Bulky metallocavitands with a chiral cavity constructed by aluminum and magnesium atrane-likes: enantioselective recognition and separation of racemic alcohols
Authors: Li Yingguo , Yu Dawei , Dai Zhongran , Zhang Jinjin , Shao Yongliang , Tang Ning , Wu Jincai
Published: February 2015

Novel tetranuclear metallocavitands with a chiral cavity were synthesized via self-assembly of aluminum/magnesium atrane-likes and were successfully applied to the chiral resolution of 2-butanol.
A simple and highly selective 2,2-diferrocenylpropane-based multi-channel ion pair receptor for Pb2+ and HSO4−
Authors: Wan Qian , Zhuo Ji-Bin , Wang Xiao-Xue , Lin Cai-Xia , Yuan Yao-Feng
Published: February 2015

A 2,2-diferrocenylpropane-based multi-channel ion pair receptor 1 was designed and structurally characterized. It was a “naked-eye-detectable” chemosensor towards Pb2+ and HSO4− with excellent selectivity and sensitivity.
Mono(boratabenzene) rare-earth metal dialkyl complexes: synthesis, structure and catalytic behaviors for styrene polymerization
Authors: Wang Xiufang , Leng Xuebing , Chen Yaofeng
Published: February 2015

Synthesis and structural characterization of mono(boratabenzene) rare-earth metal dialkyl complexes were achieved by using multi-substituted boratabenzene ligands, and the synthesized scandium complexes show high catalytic activities for syndiotactic styrene polymerization upon activation with cocatalysts.
Kinetic and multidimensional profiling of accelerated degradation of oil sludge by biostimulation
Authors: Dong Yijie , Lang Zhe , Kong Xian , Lu Diannan , Liu Zheng
Published: February 2015

Component variation and microbial ecology evolution during biostimulation treatment of oil sludge.
Mechano-electrochemistry effects due to deformation of copper oxide films
Authors: Kramer Denis , Wang Yikun , Wharton Julian
Published: February 2015

In an attempt to elucidate the relationship and underlying processes of metal oxidation under stress, we combined the electrochemical characterisation with Density-Functional-Theory (DFT) calculations to interrogate the (100) surface of copper. The oxidised (100) surface shows a missing-row reconstruction, which is believed to be driven by surface stress. Hence, additional mechanical stimuli might have a significant impact on the onset of Cu oxidation. We find that different surface sites respond differently to strain. Oads at the thermodynamically favoured high-coordination hollow site (O coordinated to four Cu) is stabilised by up to 130 meV by imposing 2% tensile strain onto the surface, while the low-coordination top site (O coordinated to one Cu) shows a markedly different sensitivity. By cramping into the hollow site, Oads induces compressive stress into the (100) surface, an effect that is largely absent for the adsorption at the top site. We also find that the thermodynamic advantage of reconstructive underpotential surface oxidation is diminished under tensile strain. Hence, imposing tensile stress counter-balances the oxygen induced surface stress, which might have an implication on the onset of bulk copper oxidation. Studying Cu(100) single crystal surfaces in perchloric acid using cyclic voltammetry, we were able to confirm sensitivity of the electrochemical response towards the elastic strain.
Microencapsulation of bioactives for food applications
Authors: Dias Maria Inês , Ferreira Isabel C. F. R. , Barreiro Maria Filomena
Published: February 2015

The potential of microencapsulation to protect bioactive compounds ensuring bioavailability maintenance is proved but requires further studies on its applicability and incentives by regulatory agencies.
An enzyme mimic ammonium polymer as a single catalyst for glucose dehydration to 5-hydroxymethylfurfural
Authors: Cao Xueqin , Teong Siew Ping , Wu Di , Yi Guangshun , Su Haibin , Zhang Yugen
Published: February 2015

An ammonium resin (PBnNH3Cl) was used as a single catalyst for the glucose and polysaccharide dehydration to 5-hydroxymethylfurfural (HMF) in high selectivity.
A urinary metabolomics study of rats after the exposure to acrylamide by ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry
Authors: Wang Sheng-Yuan , Wang Yue , Jin Xin-Wen , Zhang Yan , Chen Jia-Shu , Ma Wei-Wei , Wu Yong-Hui , Wang De-Cai
Published: February 2015

Acrylamide (ACR) is known to induce neurotoxicity in humans and occupational exposure to ACR has an effect on human health.
Controlling the morphology, composition and crystal structure in gold-seeded GaAs1−xSbxnanowires
Authors: Yuan Xiaoming , Caroff Philippe , Wong-Leung Jennifer , Tan Hark Hoe , Jagadish Chennupati
Published: February 2015

GaAs1−xSbxnanowires show zinc blende twin free structure at low TMSb flow while high TMSb flow results in inclined faults and nanowire kinking thanks to its surfactant role. Increase of wetting angle is observed, replying the change of surface energy.
Porous metallic MoO2-supported MoS2 nanosheets for enhanced electrocatalytic activity in the hydrogen evolution reaction
Authors: Yang Linjing , Zhou Weijia , Hou Dongman , Zhou Kai , Li Guoqiang , Tang Zhenghua , Li Ligui , Chen Shaowei
Published: February 2015

Porous metallic MoO2-supported MoS2 nanosheets exhibit excellent electrocatalytic activity for HER and robust electrochemical durability.
In situ visualization of metallurgical reactions in nanoscale Cu/Sn diffusion couples
Authors: Yin Qiyue , Gao Fan , Gu Zhiyong , Stach Eric A. , Zhou Guangwen
Published: February 2015

The Cu–Sn metallurgical soldering reaction in two-segmented Cu–Sn nanowires is visualized by in situ transmission electron microscopy.
Selective killing of hepatocellular carcinoma HepG2 cells by three-dimensional nanographene nanoparticles based on triptycene
Authors: Xiong Xiaoqin , Gan Lu , Liu Ying , Zhang Chun , Yong Tuying , Wang Ziyi , Xu Huibi , Yang Xiangliang
Published: February 2015

The distinct intracellular behaviors and ROS-mediated cytotoxicity are responsible for selective killing of HepG2 cells by three-dimensional nanographene nanoparticles.
Core–shell hybrid upconversion nanoparticles carrying stable nitroxide radicals as potential multifunctional nanoprobes for upconversion luminescence and magnetic resonance dual-modality imaging
Authors: Chen Chuan , Kang Ning , Xu Ting , Wang Dong , Ren Lei , Guo Xiangqun
Published: February 2015

A nitroxide radicals doped SiO2 was coated on upconversion nanoparticles to generate novel UCNP@TEMPO@SiO2 nanoprobes for dual-modality imaging.
Biodegradable polymeric micelle-encapsulated doxorubicin suppresses tumor metastasis by killing circulating tumor cells
Authors: Deng Senyi , Wu Qinjie , Zhao Yuwei , Zheng Xin , Wu Ni , Pang Jing , Li Xuejing , Bi Cheng , Liu Xinyu , Yang Li , Liu Lei , Su Weijun , Wei Yuquan , Gong Changyang
Published: February 2015

Doxorubicin (Dox) micelles showed improved anti-metastasis activity by killing circulating tumor cells (CTCs) in zebrafish and mouse models, which may have potential applications in cancer therapy.
BODIPY–BODIPY dyad: assessing the potential as a viscometer for molecular and ionic liquids
Authors: Kimball Joseph D. , Raut Sangram , Jameson Laramie P. , Smith Nicholas W. , Gryczynski Zygmunt , Dzyuba Sergei V.
Published: February 2015

The fluorescent lifetimes of the BODIPY–BODIPY dyad appear to correlate with the viscosity of the media, thus making this rotor a suitable small molecule viscometer.
An environmentally friendly approach to the green synthesis of azo dyes in the presence of magnetic solid acid catalysts
Authors: Safari Javad , Zarnegar Zohre
Published: February 2015

Fe3O4@SiO2-SO3H as a highly active catalyst for the rapid diazotization reaction and synthesis of azo-dyes under solvent-free conditions by a grinding method at room temperature is described.
Optimization of the theoretical photosynthesis performance and vision-friendly quality of multi-package purplish white LED lighting
Authors: Oh Ji Hye , Kang Heejoon , Park Hoo Keun , Do Young Rag
Published: February 2015

This study introduces the new figures of merit for photosynthesis and photo-pigmentation performance as well as vision performance for photosynthetically efficient, vision-friendly and tunable greenhouse LED lighting sources.
Sonication-induced effects on carbon nanofibres in composite materials
Authors: Gately Reece D. , Warren Holly , Scardamaglia Mattia , Romeo Tony , Bittencourt Carla , in het Panhuis Marc
Published: February 2015

The preparation, characterization and filling of carbon nanofibre–gellan gum composite materials is presented.
Hierarchical porous carbon based on the self-templating structure of rice husk for high-performance supercapacitors
Authors: Liu Dechen , Zhang Wenli , Lin Haibo , Li Yang , Lu Haiyan , Wang Yan
Published: February 2015

Hierarchical porous carbon based on the self-templating structure of rice husk was prepared for high-performance supercapacitors.
Synthesis of ZnO nanosheets decorated with Au nanoparticles and its application in recyclable 3D surface-enhanced Raman scattering substrates
Authors: Xiao Chuan-hai , Xiao Bing-xin , Wang Yu-da , Zhang Jian , Wang Shuang-ming , Wang Pan , Yang Tian-ye , Zhao Rui , Yu Hai , Li Zhi-fang , Zhang Ming-zhe
Published: February 2015

ZnO nanosheets decorated with Au nanoparticles by galvanic reduction method and its application in recyclable 3D surface-enhanced Raman scattering substrates.
[Et3NH][HSO4]-catalyzed eco-friendly and expeditious synthesis of thiazolidine and oxazolidine derivatives
Authors: Malla Ali Mohammed , Parveen Mehtab , Ahmad Faheem , Azaz Shaista , Alam Mahboob
Published: February 2015

Facile, sustainable and efficient synthesis of thiazolidine/oxazolidine derivatives.
Abnormal dielectric properties and phase transition in Bi0.783(Mo0.65V0.35)O4 scheelite-related structured ceramic
Authors: Zhou Di , Li Wen-Bo , Pang Li-Xia , Yue Zhen-Xing , Pang Guang-Sheng , Yao Xi
Published: February 2015

In the present work, an interesting phase transition at 150 °C in ordered scheelite structured Bi0.783(Mo0.65V0.35)O4 ceramic was observed for the first time.
Enhance protection of electronic appliances through multivariate modelling and optimization of ceramic core materials in varistor devices
Authors: Dorraj Masoumeh , Abdollahi Yadollah , Mohd Said Suhana Binti , Bin Mohd Sabri Mohd Faizul , Sairi Nor Asrina , Meng Woi Pei , Abouzari-lotf Ebrahim
Published: February 2015

E-waste comprises discarded low quality protected electronic appliances that annually accumulate a million tons of hazardous materials in the environment.
Improvement of crystallization and particle size distribution of boric acid in the processing of a boron carbide precursor
Authors: Gao Yong , Rafaniello William , Toksoy Muhammet Fatih , Munhollon Tyler , Haber Richard
Published: February 2015

Nano boric acid crystal fabrication from the combined effect of hexane and dispersant.
Fabrication and characterization of β-PbO2/α-PbO2/Sb–SnO2/TiO2nanotube array electrode and its application in electrochemical degradation of Acid Red G
Authors: Wu Jia , Xu Hao , Yan Wei
Published: February 2015

A novel β-PbO2/α-PbO2/Sb–SnO2/TiO2nanotube array electrode was fabricated and investigated for the treatment of Acid Red G (ARG) in aqueous solution.
Enhancing aerobic digestion of full-scale waste activated sludge using free nitrous acid pre-treatment
Authors: Wang Qilin , Yuan Zhiguo
Published: February 2015

A novel strategy based on free nitrous acid pre-treatment to enhance full-scale WAS degradation in aerobic digestion is presented.
Engineered graphene–nanoparticle aerogel composites for efficient removal of phosphate from water
Authors: Tran Diana N. H. , Kabiri Shervin , Wang Luoshan , Losic Dusan
Published: February 2015

The synthesis of a 3D self-assembled graphene–iron nanoparticle aerogel composite for the removal of phosphate is demonstrated with outstanding performance.
Near infrared photoluminescence of the univalent bismuth impurity center in leucite and pollucite crystal hosts
Authors: Romanov A. N. , Veber A. A. , Vtyurina D. N. , Fattakhova Z. T. , Haula E. V. , Shashkin D. P. , Sulimov V. B. , Tsvetkov V. B. , Korchak V. N.
Published: February 2015

The bismuth doped aluminosilicate phases leucite (KAlSi2O6), gallium leucite (KGaSi2O6) and pollucite (CsAlSi2O6) display broadband NIR photoluminescence.
Light sensitization of DNA nanostructures via incorporation of photo-cleavable spacers
Authors: Kohman Richie E. , Han Xue
Published: February 2015

Using light irradiation as a trigger, large-scale structural reconfiguration of DNA nanostructures is demonstrated.
Iron-catalyzed tandem cyclization of olefinic dicarbonyl compounds with benzylic Csp3–H bonds for the synthesis of dihydrofurans
Authors: Guo Li-Na , Wang Shun , Duan Xin-Hua , Zhou Shi-Liu
Published: February 2015

A novel iron-catalyzed radical cyclization of olefinic dicarbonyl compounds with benzyl hydrocarbons and simple alkanes has been developed. This protocol provides ready access to a variety of dihydrofurans containing a quaternary carbon center in moderate to good yields.
Unprecedented pseudo-ortho and ortho metallation of [2.2]paracyclophanes – a methyl group matters
Authors: Enders Mirja , Friedmann Christian J. , Plessow Philipp N. , Bihlmeier Angela , Nieger Martin , Klopper Wim , Bräse Stefan
Published: February 2015

The first example of a pseudo-ortho metallation on [2.2]paracyclophane is presented, giving easy access to enantiopure compounds of this type.
Integrated SnO2nanorod array with polypyrrole coverage for high-rate and long-life lithium batteries
Authors: Zhang Lei , Zhao Kangning , Xu Wangwang , Dong Yifan , Xia Rui , Liu Fengning , He Liang , Wei Qiulong , Yan Mengyu , Mai Liqiang
Published: February 2015

Conversion/alloying reactions, in which more lithium ions are involved, are severely handicapped by the dramatic volume changes.
Substrate channel evolution of an esterase for the synthesis of cilastatin
Authors: Luan Zheng-Jiao , Li Fu-Long , Dou Shuai , Chen Qi , Kong Xu-Dong , Zhou Jiahai , Yu Hui-Lei , Xu Jian-He
Published: February 2015

Error-prone PCR and site-directed mutagenesis around substrate channel were employed for improving an esterase (RhEst1) activity towards Cilastatin building block.RhEst1A147I/V148F/G254Ashowed 20 times higher activity than the native enzyme in whole cell biotransformation.
An anionic phosphenium complex as an ambident nucleophile
Authors: Stadelmann B. , Bender J. , Förster D. , Frey W. , Nieger M. , Gudat D.
Published: February 2015

Treatment of an N-heterocyclic chlorophosphine with Collman's reagent or K[HFe(CO)4]/NaH gave a unique anionic phosphenium complex which behaves as an ambident nucleophile.
Metallacyclic yttrium alkyl and hydrido complexes: synthesis, structures and catalytic activity in intermolecular olefin hydrophosphination and hydroamination
Authors: Kissel Alexander A. , Mahrova Tatyana V. , Lyubov Dmitry M. , Cherkasov Anton V. , Fukin Georgy K. , Trifonov Alexander A. , Del Rosal Iker , Maron Laurent
Published: February 2015

Yttrium complexes – efficient precatalysts for intermolecular olefin hydrophosphination and hydroamination.
Global transcriptional analysis of Escherichia coli expressing IrrE, a regulator from Deinococcus radiodurans, in response to NaCl shock
Authors: Zhao Peng , Zhou Zhengfu , Zhang Wei , Lin Min , Chen Ming , Wei Gehong
Published: February 2015

Improving the microbial tolerance to stresses is very important for bioprocesses.
Dumbbell-like Au-Fe3O4 nanoparticles: a new nanostructure for supercapacitors
Authors: Liu Sheng , Guo Shaojun , Sun Shouheng , You Xiao-Zeng
Published: February 2015

Monodispersed dumbbell-like Au-Fe3O4 nanoparticles (NPs) were synthesized and studied for supercapacitors. The NPs show Au/Fe3O4-size dependent capacitive behaviors with the best specific capacitance of 464 F g−1 at 1 A g−1. This capacitive enhancement is believed to arise from Au-induced increase in electron transfer across the NPs demonstrating a new strategy to enhance oxide NP capacitances.
Concise total syntheses of (±)-mesembrane and (±)-crinane
Authors: Das Mrinal Kanti , De Subhadip , Shubhashish Shubhashish , Bisai Alakesh
Published: February 2015

A unified approach to the Amaryllidaceae alkaloids having a cis-3a-aryloctahydroindole scaffold is developed via a key Eschenmoser–Claisen rearrangement of all-carbon quaternary stereocenters present in these alkaloids. Utilizing this strategy, a concise total synthesis of (±)-mesembrane and (±)-crinane is achieved.
An artificial heme-enzyme with enhanced catalytic activity: evolution, functional screening and structural characterization
Authors: Vitale Rosa , Lista Liliana , Cerrone Corinne , Caserta Giorgio , Chino Marco , Maglio Ornella , Nastri Flavia , Pavone Vincenzo , Lombardi Angela
Published: February 2015

The rational refinement of function into the heme-protein model Mimochrome VI (MC6) resulted in a new analogue, FeIII-E2L(TD)-MC6, with an improved peroxidase activity.
A novel AgNPs-based colorimetric sensor for rapid detection of Cu2+ or Mn2+via pH control
Authors: Wu Genhua , Dong Chen , Li Yonglong , Wang Zhuqing , Gao Yuexia , Shen Zheyu , Wu Aiguo
Published: February 2015

The AgNPs-based colorimetric sensor at pH 1.9 or 12.0 can respectively be used for rapid detection of Cu2+ or Mn2+.
Stability of hydrogenated graphene: a first-principles study
Authors: Yi Ding , Yang Liu , Xie Shijie , Saxena Avadh
Published: February 2015

Hydrogenated graphene becomes more stable when hydrogen atoms are adsorbed on graphene from both sides due to the increased carbon–carbon sp3 hybridization.
SAR studies of 3,14,19-derivatives of andrographolide on anti-proliferative activity to cancer cells and toxicity to zebrafish: an in vitro and in vivo study
Authors: Peng Yuran , Li Jingjing , Sun Yicheng , Chan Judy Yuet-Wa , Sheng Dekuan , Wang Kun , Wei Ping , Ouyang Pingkai , Wang Decai , Lee Simon Ming Yuen , Zhou Guo-Chun
Published: February 2015

Andrographolide is bestowed with an interesting pharmacophore and has attracted numerous studies on the design and synthesis of andrographolide derivatives.
Portable and quantitative evaluation of stem cell therapy towards damaged hepatocytes
Authors: Zhao Lifang , Wei Qin , Wu Hua , Li He , Li Dong , Mohapatra Shyam S.
Published: February 2015

Stem cell therapy has recently emerged as a breakthrough technology to treat a variety of diseases.
Bottom-up growth of Ag/a-Si@Ag arrays on silicon as a surface-enhanced Raman scattering substrate with high sensitivity and large-area uniformity
Authors: Liu Liwei , Jin Mingliang , Zhou Qingwei , Zhan Runze , Chen Huanjun , Gao Xingsen , Senz Stephan , Zhang Zhang , Liu Junming
Published: February 2015

Bottom-up growth of Ag/a-Si@Ag arrays on Si, which worked as a highly sensitive SERS substrate.
Flexible and enhanced thermal conductivity of a Al2O3@polyimide hybrid film via coaxial electrospinning
Authors: Xia Jianwen , Zhang Guoping , Deng Libo , Yang Haipeng , Sun Rong , Wong Ching-Ping
Published: February 2015

A core–shell Al2O3@PI fiber was prepared by coaxial electrospinning, which showed excellent properties of flexibility and in plane thermal conductivity.
Mn-doped ZnS quantum dots with a 3-mercaptopropionic acid assembly as a ratiometric fluorescence probe for the determination of curcumin
Authors: Zhao Xiaojuan , Li Fengxia , Zhang Qingyan , Li Zengbo , Zhou Yehong , Yang Jun , Dong Chuan , Wang Junping , Shuang Shaomin
Published: February 2015

Mn-doped ZnS quantum dots capped with 3-mercaptopropionic acid (MPA) were synthesized by a facile method in aqueous solution as a ratiometric fluorescent (I590 nm/I458 nm) probe for curcumin.
P34HB film promotes cell adhesion, in vitro proliferation, and in vivo cartilage repair
Authors: Fu Na , Xie Jing , Li Guo , Shao Xiaoru , Shi Sirong , Lin Shiyu , Deng Shuwen , Sun Ke , Lin Yunfeng
Published: February 2015

The management of chondral defects is a challenging topic of current interest for scientists and surgeons, which has a crucial impact on human cost.
Antimony sulfide as a light absorber in highly ordered, coaxial nanocylindrical arrays: preparation and integration into a photovoltaic device
Authors: Wu Yanlin , Assaud Loïc , Kryschi Carola , Capon Boris , Detavernier Christophe , Santinacci Lionel , Bachmann Julien
Published: February 2015

Functional ‘extremely thin absorber’ solar cells consisting of parallel, nanocylindrical, concentric p-i-n heterojunctions are prepared by atomic layer deposition.
Fabrication of pH- and temperature-directed supramolecular materials from 1D fibers to exclusively 2D planar structures using an ionic self-assembly approach
Authors: Gong Yanjun , Hu Qiongzheng , Cheng Ni , Wang Tao , Xu Wenwen , Bi Yanhui , Yu Li
Published: February 2015

Constructing multiple-response smart materials is a very interesting and challenging task in materials science.
Interplay between local environments and photoluminescence of Eu2+in Ba2Zr2Si3O12: blue shift emission, optimal bond valence and luminescence mechanisms
Authors: Zhang Yang , Li Xuejiao , Li Kai , Lian Hongzhou , Shang Mengmeng , Lin Jun
Published: February 2015

Tunable luminescence (from green to cyan) and an increased thermal stability have been obtained in a BZSO:Eu2+system through the cation substitutions of Ca2+/Sr2+for Ba2+.
Water as a colorful ink: transparent, rewritable photonic coatings based on colloidal crystals embedded in chitosan hydrogel
Authors: Du Xuemin , Li Tengyue , Li Lijun , Zhang Zhicheng , Wu Tianzhun
Published: February 2015

A rewritable and environmentally friendly paper using water as the ink is fabricated, and various colors can be achieved.
“It's Not Humanly Possible to Do Everything”: Perspectives on Intervention Decision-Making Processes of Parents of Children with Autism Spectrum Disorders
Authors: Finke Erinn , Drager Kathryn , Serpentine Elizabeth C.
Published: February 2015

Purpose

The purpose of this investigation was to understand the decision-making processes used by parents of children with autism spectrum disorder (ASD) related to communication-based interventions.

Method

Qualitative interview methodology was used. Data were gathered through interviews. Each parent had a child with ASD who was at least four-years-old; lived with their child with ASD; had a child with ASD without functional speech for communication; and used at least two different communication interventions.

Results

Parents considered several sources of information for learning about interventions and provided various reasons to initiate and discontinue a communication intervention. Parents also discussed challenges introduced once opinions of the school individualized education program (IEP) team had to be considered.

Conclusions

Parents of children with ASD primarily use individual decision-making processes to select interventions. This discrepancy speaks to the need for parents and professionals to share a common “language” about interventions and the decision-making process.
Chromatic‐dispersion‐free transmission using time‐reversal optical parametric amplifier
Authors: Ou Haiyan , Zhang Chi , Xu Xing , Lam Edmund Y. , Wong Kenneth K.Y.
Published: February 2015

A chromatic‐dispersion‐free transmission using a time‐reversal optical parametric amplifier (OPA) for 10 Gbit/s data over 25 km of standard single‐mode fibre is demonstrated. The time‐reversal was achieved using optical phase conjugation in the OPA. A pilot signal was first sent to estimate the optical channel, which would be reshaped by the OPA and then retransmitted with data through the same fibre. The dispersion is compensated automatically through the transmission. Experimental results showed that around 1 dB improvement can be obtained at a bit error rate of <10−9 compared to the traditional return‐to‐zero on–off keying link.
Wireless wearable range‐of‐motion sensor system for upper and lower extremity joints: a validation study
Authors: Kumar Yogaprakash , Yen Shih‐Cheng , Tay Arthur , Lee Wangwei , Gao Fan , Zhao Ziyi , Li Jingze , Hon Benjamin , Tian‐Ma Xu Tim , Cheong Angela , Koh Karen , Ng Yee‐Sien , Chew Effie , Koh Gerald
Published: February 2015

Range‐of‐motion (ROM) assessment is a critical assessment tool during the rehabilitation process. The conventional approach uses the goniometer which remains the most reliable instrument but it is usually time‐consuming and subject to both intra‐ and inter‐therapist measurement errors. An automated wireless wearable sensor system for the measurement of ROM has previously been developed by the current authors. Presented is the correlation and accuracy of the automated wireless wearable sensor system against a goniometer in measuring ROM in the major joints of upper (UEs) and lower extremities (LEs) in 19 healthy subjects and 20 newly disabled inpatients through intra (same) subject comparison of ROM assessments between the sensor system against goniometer measurements by physical therapists. In healthy subjects, ROM measurements using the new sensor system were highly correlated with goniometry, with 95% of differences < 20° and 10° for most movements in major joints of UE and LE, respectively. Among inpatients undergoing rehabilitation, ROM measurements using the new sensor system were also highly correlated with goniometry, with 95% of the differences being < 20° and 25° for most movements in the major joints of UE and LE, respectively.
DC link voltage balancing approach for cascaded H‐bridge active rectifier based on selective harmonic elimination‐pulse width modulation
Authors: Moeini Amirhossein , Iman‐Eini Hossein , Marzoughi Alinaghi
Published: February 2015

This study presents an improved voltage balancing strategy which can be employed on multilevel cascaded H‐bridge (CHB) rectifiers using low switching frequency. The proposed method balances the voltage of all DC links in a CHB rectifier to a predefined value, without increasing the number of switching transitions. The redundancy states which are available in the CHB rectifier to produce a voltage level are used to balance the DC links in each transition. Moreover, using the well‐known selective harmonic elimination‐pulse width modulation method, all current harmonic components up to 29th harmonic are eliminated in the three‐phase CHB rectifier, whereas the average switching frequency of each switch is limited to 150 Hz. The effectiveness and validity of the proposed strategy is verified by several simulations and experiments that are carried out on a 7‐level CHB rectifier.
Decoupling controller design for Z‐source inverter
Authors: Tsang Kai‐Ming , Chan Wai‐Lok
Published: February 2015

With the state‐space averaging model and the proposed pulse‐width modulation switching scheme, the Z‐source inverter has been decoupled into a primary boosting stage and a secondary bucking stage. Two double‐loop controllers are designed to handle the voltage regulation as well as the current regulation for the DC/DC and DC/AC conversion processes. The proposed scheme demands for two separate duty ratios and novel switching scheme has been derived to realise the combined duty ratios in one switching cycle. Power regulation, harmonics elimination and power factor correction control algorithms have also been derived for the Z‐inverter when it is connected to the supply grid. Finally, experimental results are included to demonstrate the effectiveness of the proposed switching and control schemes.
Analysis and simulation for broadening first‐order sea clutter spectrum in high frequency hybrid sky‐surface wave propagation mode
Authors: Ya‐jun Li , Yin‐sheng Wei , Yong‐peng Zhu , Ru‐jiang Guo , Zhuo‐qun Wang , Rong‐qing Xu
Published: February 2015

In high frequency (HF) hybrid sky‐surface wave radar, the first‐order sea clutter broadening is very severe under the influence of ionosphere and bistatic angle, which affects the detection of slow ship target. This study analyses and simulates the broadening first‐order sea clutter spectrum based on a modified first‐order ocean surface radar cross‐section (RCS) model using wide beam. The authors first introduce the working principle, range equation and positioning principle based on the newly‐developed integrated HF sky‐surface experimental system; and derive an expression for the first‐order Bragg frequency. Also presented is a modified RCS model of first‐order sea clutter, in which the HF sea clutter spectrum distribution characteristics and broadening mechanism are fully considered. Finally, the proposed broadening first‐order sea clutter spectrum model is examined by measured data. Simulation results indicate that the proposed first‐order sea clutter spectrum model can well describe the characteristics of measured sea clutter.
Unscented Kalman filter‐aided Gaussian sum filter
Authors: Gokce Murat , Kuzuoglu Mustafa
Published: February 2015

A non‐linear filter is developed for continuous‐time systems with observations/measurements carried out in discrete‐time. The filter developed can approximate the a priori and a posteriori probability density function (pdf) with weighted Gaussian sums inside specific search regions. To make the approximations, first, Gaussians are placed with equal intervals inside the search regions and deterministic sample points are chosen within the search regions. The pdf values are then calculated at sample points using numerical solution of the Fokker–Planck equation for the a priori pdf and using Bayes’ rule for the a posteriori pdf. These values are used to find the weights of Gaussians using least‐squares method. This process is similar to curve fitting with Gaussian radial basis functions. Inside the search regions, locations of the sample points and mean and covariance values of Gaussians are found by the help of a unscented Kalman filter (UKF). By adjusting the width of the search regions, all the parts, or the ones close to mean values of pdfs, can be approximated. The performance of the filter developed is analysed using a non‐linear system with a single‐state variable and two radar tracking applications. It is compared with particle filter, UKF and converted measurement Kalman filter for these cases.
Parameter estimation of manoeuvring targets based on segment integration and Lv's transform
Authors: Tian Jing , Cui Wei , Lv Xiao‐lei , Wu Shuang , Wu Si‐liang
Published: February 2015

In this paper, the received signal in a range cell is modelled as a multi‐component linear frequency‐modulated (LFM) signal after range compression and motion compensation, and a new method based on segment integration and Lv's transform (LVT) is introduced for parameter estimation of LFM signals over long observation interval. In this method, the LFM signals are firstly divided into segments and fast Fourier transform (FFT) is then applied within each signal segment. After that, the same frequency resolution bins of each segment are selected to construct new series and inter‐segment LVT is implemented to obtain the parameter estimates. The criteria to choose the number of segments, output signal‐to‐noise ratio, computational complexity and memory cost are analysed in detail for this new approach. This method is fast and able to obtain the accurate parameter estimates by using the complex multiplications and FFT. Comparisons with other popular methods, LVT, maximum‐likelihood estimation and fractional Fourier transform are performed. Experimental results demonstrate the proposed method is capable of obtaining the accurate parameter estimates with low computational burden and storage memory, making it suitable to be applied in memory‐limited and real‐time processing systems.
Accuracy assessment of airborne laser scanner dataset by means of parametric and non‐parametric statistical methods
Authors: Rodríguez‐Gonzálvez Pablo , González‐Aguilera Diego , Hernández‐López David , González‐Jorge Higinio
Published: February 2015

Parametric and non‐parametric statistical methods are compared and discussed for the accuracy assessment of digital surface models coming from airborne laser scanner. Such datasets are chosen from different types of areas: from the relatively favourable flat terrain to the complex built‐up areas and abrupt terrain zones with vegetation. For those complex sites, a reference ‘ground truth’ is established using a mobile mapping system, whereas flat terrain areas are checked through static ground surveying using global positioning system. The experimental results confirm that systematic errors and many outliers remain in the airborne laser scanner dataset corresponding to built‐up and abrupt terrain areas, and thus that nonparametric statistical methods are suitable for an accuracy assessment.
Recent Development in N-Auxilixary-Assisted Intramolecular Amination for Amine Substrates
Authors: Zhao Yingsheng , Wang Chao , Han Jian
Published: February 2015

Direct coupling of N–H with C–H has aroused great attention in the last decades; during which the directing-group-assisted intramolecular C–N bond formation via transition metal has been achieved significant progress. Herein, we highlight the recent development in the directing-group-assisted intramolecular amination for amine substrates to build the important N-containing heterocyclic compounds.

1 Introduction

2 Triflamide-Promoted Intramolecular Amination

3 Picolinamide-Assisted Intramolecular Amination

4 Palladium-Catalyzed Intramolecular Amination under Assistance of Oxalyl Amide

5 Conclusion
A Design Theory for Digital Platforms Supporting Online Communities: A Multiple Case Study
Authors: Spagnoletti Paolo , Resca Andrea , Lee Gwanhoo
Published: February 2015

This research proposes and validates a design theory for digital platforms that support online communities (DPsOC). It addresses ways in which digital platforms can effectively support social interactions in online communities. Drawing upon prior literature on IS design theory, online communities, and platforms, we derive an initial set of propositions for designing effective DPsOC. Our overarching proposition is that three components of digital platform architecture (core, interface, and complements) should collectively support the mix of the three distinct types of social interaction structures of online community (information sharing, collaboration, and collective action). We validate the initial propositions and generate additional insights by conducting an in-depth analysis of an European digital platform for elderly care assistance. We further validate the propositions by analyzing three widely used digital platforms, including Twitter, Wikipedia, and Liquidfeedback, and we derive additional propositions and insights that can guide DPsOC design. We discuss the implications of this research for research and practice.
Electronic and magnetic properties of zigzag silicene nanoribbons with Stone–Wales defects
Authors: Dong Haixia , Fang Dangqi , Gong Baihua , Zhang Yang , Zhang Erhu , Zhang Shengli
Published: February 2015

The structural, electronic, and magnetic properties of zigzag silicene nanoribbons (ZSiNRs) with Stone–Wales (SW) defects were investigated using first-principles calculations. We found that two types of SW defects (named SW-Ι and SW-ΙΙ) exist in ZSiNRs. The SW defect was found to be the most stable at the edge of the ZSiNR, independently of the defect orientation, even more stable than it is in an infinite silicene sheet. In addition, the ZSiNRs can transition from semiconductor to metal or half-metal by modifying the SW defect location and concentration. For the same defect concentration, the band structures influenced by the SW-Ι defect are more distinct than those influenced by the SW-ΙΙ when the SW defect is at the edge. The present study suggests the possibility of tuning the electronic properties of ZSiNRs using the SW defects and might motivate their potential application in nanoelectronics and spintronics.