bluuebunny/crossref_metadata_2025 huggingface dataset:
Profiling Intangible Cultural Heritage Visitors through Multilayer Perceptron’s model
Authors: Castaño-Prieto Lucía , Solano-Sánchez Miguel Ángel , Hidalgo-Fernández Amalia , López-Guzmán Tomás
Published: January 2025

UNESCO’s Intangible Cultural Heritage elements are perceived as valuable tourist resources by the various governments and local entities responsible for managing destinations. Consequently, from a tourism perspective, this recognition confers a competitive advantage to the destination. This research seeks to determine the variations in the socio-demographic profile (gender, age, educational level and income) of tourists interested in Intangible Cultural Heritage elements. The study is based on the development of an artificial neural network. This approach allows the construction of potential “identikits” or estimated profiles of tourists participating in the Fiesta de los Patios (Cordoba, Spain) based on the answers incorporated into the artificial neural network as customisable inputs. This is especially useful for elaborating products and services adapted to tourists interested in the different elements, customs and traditions registered as Intangible Cultural Heritage. While this methodology has been applied to the tourism sector, it has yet to be applied to tourists interested in Intangible Cultural Heritage. This research aims to address this gap in the literature. It can be deduced that to attract a particular profile with a high income, which would have a more significant effect on the economic development of a destination, it is necessary to promote accessibility and public transport, especially on the days that the event takes place. To address the issue of overcrowding, a ‘per-entry’ fee is proposed for the patios, or a tourist tax to be imposed in the city of Cordoba.
Determining the Accuracy and Interobserver Agreement of 4 Ultrasound Scores in Crohn's Disease Assessment: Correlations With Endoscopy
Authors: Qin Jing , Ma Li , Zhou Meng-Yuan , Li Wen-Bo , Xiao Meng-Su , Niu Zi-Han , Yang Hong , Zhu Qing-Li
Published: January 2025

INTRODUCTION:

Gastrointestinal ultrasound (GIUS) is recommended for monitoring Crohn's disease (CD). GIUS scores are used to quantify CD activity. Among them, International Bowel Ultrasound Segmental Activity Score (IBUS-SAS), Bowel Ultrasound Score (BUSS), Simple Ultrasound Score, and Simple Ultrasound Score for Crohn's Disease are most commonly used. The aim of this study was to compare and correlate the performance of such indicators with endoscopic activity and to calculate interobserver agreement.

METHODS:

Consecutive patients with CD at our hospital between June 2015 and July 2021 were retrospectively enrolled. All patients underwent ileocolonoscopy after medical treatment. GIUS was performed within 2 weeks, and 4 GIUS scores were independently calculated. Receiver operating characteristic curve analyses were used to determine a cutoff value. Cohen kappa (κ) coefficient was calculated to estimate the agreement between GIUS findings.

RESULTS:

A total of 106 patients with CD were enrolled. 80.2% (85/106) were endoscopic active (Simple Endoscopic Score for Crohn's disease ≥3), and 8.49% (9/106) were severe cases (Simple Endoscopic Score for Crohn's disease ≥9). All GIUS features (bowel wall thickness, color Doppler signs, bowel wall stratification, inflammatory signals at the mesentery) were statistically significant in assessing CD activity (P < 0.05). IBUS-SAS showed the highest area under the curve (0.98; 95% CI: 0.96–1.00) and specificity (95.2%) for a cutoff value of 46.50. However, IBUS-SAS had only moderate agreement (Cohen κ = 0.427; P < 0.001). BUSS had substantial interobserver agreement (Cohen κ = 0.947; P < 0.001), with a similar diagnostic value (sensitivity, 100.0%; accuracy, 95.3%; area under the curve of 0.96 [95% CI: 0.91–1.00] for a cutoff value of 4.58).

DISCUSSION:

GIUS score is an efficient and reliable method to assess CD activity. BUSS achieved a high accuracy and excellent interobserver agreement, which is more suitable for treatment assessment.
Aprendizaje y servicio en Ciencias de la Actividad Física y del Deporte: «Nadando hacia nuevas oportunidades»
Authors: Martín-López Isabel M. , García-Taibo Olalla
Published: January 2025

El Aprendizaje-servicio (ApS) es una metodología educativa que integra el compromiso social con el aprendizaje académico, permitiendo a los estudiantes desarrollar competencias en contextos reales. Se ha implementado en diversas áreas, incluyendo la Educación Física, con beneficios tanto para los estudiantes como para la comunidad. Teniendo en cuenta que son pocos los estudios que se han centrado en evaluar el efecto del ApS sobre los receptores del servicio, el objetivo del presente estudio fue mejorar las habilidades acuáticas de personas en riesgo de exclusión social y mejorar la competencia prosocial del alumnado universitario. Se utilizó un diseño cuasiexperimental con medición pre-post sin grupo control. La muestra incluyó a 21 estudiantes y 13 participantes pertenecientes a Cáritas Mallorca. Se evaluaron las habilidades acuáticas de los participantes y las competencias ciudadanas, prosociales e inclusivas del alumnado mediante cuestionarios y escalas pre y post programa. El programa consistió en 16 sesiones de familiarización en el medio acuático durante 8 semanas. Se observó una mejora¡ significativa en las habilidades acuáticas de los participantes. Sin embargo, no se encontraron diferencias significativas en las competencias ciudadanas, prosociales e inclusivas del alumnado entre la evaluación pre y post programa. La satisfacción del alumnado fue positiva, destacándose el aprendizaje y las competencias profesionales adquiridas. Se recomienda mejorar la planificación del programa y la participación en los procesos de evaluación para futuras implementaciones. El ApS se destaca como una metodología eficaz en Ciencias de la Actividad Física y Deporte (CAFYD), proporcionando beneficios tanto para la sociedad como para la formación profesional de los estudiantes.
Celebrando 20 anos de JCDR: avanços e legado na Periodontia e Implantodontia
Authors: Araújo Maurício
Published: January 2025

﻿Há 20 anos, recebi o honroso convite para assumir a posição de Editor-chefe da Revista Dental Press de Periodontia e Implantodontia (atual JCDR), um marco significativo na minha trajetória profissional. Recordo-me vividamente do nosso primeiro entrevistado, o ilustre Prof. Jan Lindhe. Que maneira extraordinária de iniciar a revista! Um momento realmente auspicioso e de grande importância. O Prof. Lindhe sempre enfatizou que, embora muitas coisas na Odontologia possam mudar com o tempo, uma verdade permanece inabalável: a necessidade do controle de placa como elemento fundamental...
Primary exploration of the One Science integrated curriculum system construction
Authors: Pan Linmin , Gu Yabei , He Feng
Published: January 2025

Under the background of the explosion of knowledge, the rapid development of new technologies, and the new trend of globalization, the reform and development of college education and teaching courses are facing new challenges. The exploration of the top-notch innovative talent cultivation model based on the integrated One Science curriculum system urgently awaits reform. The One Science integrated curriculum system focuses on the integration of disciplines, breaking down disciplinary barriers, and aiming at cultivating students’ general understanding abilities and the innovative capabilities of future scientists. This paper introduces the necessity and reform practice exploration of the One Science integrated curriculum system, and further discusses the challenges and prospects of the integrated curriculum system reform.
Clinical manifestations and molecular genetics of seven patients with Niemann–Pick type-C: a case series with a novel variant
Authors: Kara Cemre , Köse Engin , Eminoğlu Fatma Tuba
Published: January 2025

Objectives

Niemann–Pick type C (NPC) is a rare, autosomal recessive, neurodegenerative disorder caused by biallelic pathogenic variants in the NPC1 or NPC2 genes, leading to lysosomal lipid accumulation. NPC has an incidence of 1 in 100,000 live births and presents with a wide range of symptoms affecting visceral organs and the central nervous system. We aim to describe the diverse clinical presentations of NPC through case studies.

Case presentation

We report seven NPC patients from five families, showcasing the variability in clinical manifestations. The most common finding was hepatosplenomegaly (70 %), followed by prolonged jaundice (57 %) and neonatal cholestasis. Pulmonary alveolar proteinosis (PAP) was observed in three patients with biallelic pathogenic variants in the NPC2 gene. Neurological symptoms, including vertical gaze palsy and epilepsy, were noted in patients with juvenile onset form. Genetic analyses identified a novel homozygous c.315del (p.Thr106ProfsTer5) variant in the NPC2 gene, associated with early infantile onset.

Conclusions

NPC presents with diverse clinical findings across ages. Early hepatic symptoms in infants and neuropsychiatric issues in older patients warrant a high index of suspicion for NPC in such cases. A multidisciplinary approach is crucial for patient management, and further research is needed to clarify genotype–phenotype relationships in NPC.
Selective HDAC8 inhibition by PCI-34051 attenuates inflammation and airway remodeling in asthma via miR-381-3p-TGFβ3 axis
Authors: Bai Shiyao , Su Xinming , Kong Delei , Feng Chenye , Zhang Xiaochun , Pan Ying , Zhao Jieyu , Sun Jiamin , Li Wenyang
Published: January 2025

Background and Objectives

Histone deacetylase (HDAC) families regulate various physical processes and the development of several diseases. The role of HDACs in asthma development and progression worths further investigation. This study aims to evaluate the effect of HDACs in a mouse model of asthma.

Methods

HDAC8 selective inhibitor PCI-34051 was administered to a mouse model of ovalbumin-sensitized and challenged asthma. Airway responsiveness, serum cytokines, histological changes of the airway, and expression levels of α-SMA, β-actin, VEGFR, VEGF, GAPDH, HDAC8, TGF-β3, CD 105, p-ERK 1/2, ERK 1/2, PI3K, p-AKT, AKT, and PDK1 were evaluated. The miR-381-3p level was also measured.

Results

All classic histologic and cellular changes of asthma in inflammation and airway remodeling were altered by HDAC8 inhibitor PCI-34051 via regulation of the miR-381-3p level and its downstream gene, TGF-β3. Inhibition of TGF-β3 further reduced the activation of ERK, PI3K, AKT, and PDK1.

Conclusion

In a mouse model, HDAC8 inhibitor PCI-34051 exhibits comprehensive control of asthmatic changes, including inflammation and airway remodeling.
A Notch signaling pathway-related gene signature: Characterizing the immune microenvironment and predicting prognosis in hepatocellular carcinoma
Authors: Shi Qingmiao , Jiang Shuwen , Zeng Yifan , Yuan Xin , Zhang Yaqi , Chu Qingfei , Xue Chen , Li Lanjuan
Published: January 2025

Background and Objectives

Prior studies have highlighted an escalating global burden of hepatocellular carcinoma (HCC). The Notch signaling pathway regulates the initiation and development of HCC and determines the HCC prognosis.

Methods

The expression data of genes related to the Notch signaling pathway were acquired from public databases. To filter prognostic gene signatures and establish the risk model, the analyses of consensus clustering, least absolute shrinkage and selection operator (LASSO), and multivariate Cox were conducted. Subsequently, the risk stratification was optimized using a decision tree and nomogram. The immune landscapes were revealed utilizing the single-sample gene set enrichment analysis, and tumor immune dysfunction and exclusion score.

Results

According to the mRNA expression profile of Notch signaling pathway-related genes, HCC patients were stratified to three clusters, which have different survival probability and immune infiltration characteristic. Subsequently, we developed a risk model based on five prognostic Notch signaling-related gene signatures (SPP1, SMG5, HMMR, PLOD2, and CFHR4). The model demonstrated an accurate estimation of overall survival, revealing alterations in immune status and immunotherapy sensitivity among HCC patients with different risk scores.

Conclusions

This study constructed a Notch signaling pathway-related prognostic model, offering valuable insights for the assessment of immune characteristics and immunotherapy responses in HCC patients.
Chinese guidelines for the diagnosis and treatment of rheumatoid arthritis: 2024 update
Authors: Tian Xinping , Wang Qian , Jiang Nan , Zhao Yan , Huang Cibo , Liu Yi , Xu Huji , Chen Yaolong , Wu Lijun , Xu Jian , Li Hongbing , Lu Liangjing , Lin Jin , Dai Lie , Li Fen , Jiang Zhenyu , Zheng Zhaohui , Shuai Zongwen , Xu Shengqian , Zhao Dongbao , Zhang Miaojia , Sun Yunlin , Liu Shengyun , Li Caifeng , Yang Pingting , Li Mengtao , Zeng Xiaofeng
Published: January 2025

Rheumatoid arthritis (RA) is an autoimmune disease with destructive arthritis as its main clinical manifestation, which is a major cause of disability. It is very important to formulate and update a guideline for the diagnosis and treatment of RA that adhere to international guideline development standards and can be applied to clinical practice in China. This guideline is endorsed and developed by the National Clinical Research Center for Dermatologic and Immunologic Diseases, collaborated with Rheumatologists Branch of Chinese Medical Doctor Association, Rheumatology Rehabilitation Branch of Chinese Association of Rehabilitation Medicine, Rheumatology Branch of Chinese Research Hospital Association, and Rheumatology Branch of Beijing Association of Holistic Integrative Medicine, based on grading of recommendations assessment, development and evaluation (GRADE) and reporting items for practice guidelines in healthcare (RIGHT). Evidence-based recommendation were developed for 10 clinical scenario that are most relevant to Chinese rheumatologists, aiming to improve and standardize the diagnosis and treatment of RA in China, which may finally improve the quality of life and prognosis of patients.
Common Neocortical and Hippocampal Correlates of Performance Errors in a Timing Task
Authors: Gielow Matthew R. , Headley Drew B. , Herzallah Mohammad M. , Paré Denis
Published: January 2025

We aimed to identify the neuronal correlates of performance errors in a difficult timing task. Male rats were trained to seek rewards and avoid shocks depending on the position of photic conditioned stimuli (CS-R and CS-S, respectively). Then, they were exposed to conflict trials where they had to time the interval between the CS-R and CS-S to obtain rewards while avoiding footshocks. There were pronounced individual differences in behavioral strategies on conflict trials. When presented with a CS-S, some rats quickly left the shock sector, forsaking the option of earning a reward, and rarely got shocked. Others earned rewards by delaying avoidance based on the interval between the CS-R and CS-S but were shocked more often. The probability rats would fail a given trial was not stable across trials as rats engaged in incorrect trial runs that were longer than expected by chance. Since this finding suggested that rats shift between two quasi-stable processing modes, we next examined the neuronal correlates of errors. Incorrect trials coincided with reduced firing rates in CA1 and sensory cortical neurons. Moreover, trial-to-trial variations in the firing rates of simultaneously recorded neurons were more strongly correlated on error than correct trials. Last, the power of low-frequency local field potential oscillations was higher during incorrect trials. The finding that the neuronal correlates of correct and error trials are similar in the hippocampus and neocortex lead us to hypothesize that they depend on changes in the activity of common afferents, such as neuromodulatory inputs.
Highly-densified panels from hyun aspen (Populus alba × glandulosa) wood with different delignification levels using alkaline hydrogen peroxide pretreatment
Authors: Pe III Justin Alfred , Mun Ji Sun , Mun Sung Phil
Published: January 2025

Defect-free, highly-densified panels without springback were prepared from Hyun aspen (Populus alba × glandulosa) wood with different delignification levels by alkaline hydrogen peroxide (AHP) pretreatment. The AHP concentrations were adjusted to 3%, 7%, 10%, while the temperature (100 °C), time (3 h), pH (11), liquor ratio (6.25), and stabilizer (0.5% EDTA) remained constant. The delignification of Hyun aspen wood panels was indirectly quantified by analyzing the UV absorbance of the spent liquor after AHP treatment, wherein delignification ranged from 12% to 58% depending on the AHP concentration. To achieve highly-densified panels, the densification conditions, such as pressure, temperature, and time, were examined. Panels subjected to cold-pressing (25 °C) at 30 MPa for 1 h, followed by hot-pressing (105 °C) at 30 MPa for 6 h, then immediately removed after heating, resulted in durable, highly-densified panels with no springback or cracks.
Prediction of L-type mitered joint behavior with linear elastic fracture mechanics: Experimental and numerical modeling
Authors: Abdolzadeh Hamideh
Published: January 2025

Numerical modeling was used for mitered joints prepared with wood-based composite members (poly(furfuryl alcohol)) using Linear Elastic Fracture Mechanics (LEFM). The aim was to understand the joint performance under outdoor conditions. Analysis of fracture mechanics properties of wood-based composite is necessary to obtain a good understanding of joint behavior and to predict the reasons for its fracture. The fracture stiffness of furfurylated wood under mixed mode (I/II) was investigated. In both crack systems, the distribution trends of KIC/KIIC with furfurylation changed. The results of corner mitered joints showed that the mixed mode I/II was the effective fracture mode under diagonal compression (DC) and tension (DT) load. Based on the results obtained from fracture mechanics, the structural performance of mitered joints increased with increasing furfurylation level. The model results confirmed the experimental results.
"Influence of Elettaria cardamomum L. and Myristica fragrans Houtt. seeds on the thermal properties and flammability of poly(lactic acid)
Authors: Majka Tomasz M.
Published: January 2025

Pharmaceutical studies have reported for many years that plants containing antioxidants have many health-promoting properties, mainly due to organic compounds capable of scavenging free radicals. In this work, the activity of two representative plant families was tested: Elettaria cardamomum L. (EC) and Myristica fragrans Houtt. (MF). Results indicate that the antioxidants contained in them decompose into gaseous products at temperatures up to about 640 K. The introduction of EC and MF to the biopolymer matrix resulted in a decrease in the thermal stability of the obtained composites. The resulting char residues acted as a local thermal insulator, which led to reduced flammability of poly(lactic acid) (PLA) composites. As a result, the use of 10 wt% EC and 7.5 wt% MF reduced flammability by 37% and 29%, respectively.
Multi-response optimization of antioxidant and total phenols-flavonoids content of polyherbal extract drink from turmeric, java tea, and seed-under-leaf
Authors: Hamad Alwani , Hartanti Dwi
Published: January 2025

The research aimed to evaluate quality profiles, optimize the antioxidant activity, and total phenolic and flavonoid content in a mixture of three crude drug: turmeric, java tea, and seed-under-leaf, using the Simplex Lattice Mixture Design. Ultimately, a quadratic model was used, as it best adjusted to the experimental behavior. It predicted the optimal composition of herbal mixtures antioxidant activity, determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and Ferri Reducing Antioxidant Power (FRAP) techniques, also in Total Phenolic Content (TPC) and Total Flavonoid Content (TFC). The crude drugs were of good quality according to selected pharmacognostic quality parameters of the official Malaysian herbal monograph (MHM). The optimum responses with the highest synergistic effect were composed of 5% (w/w) of turmeric, 40% (w/w) of Java tea, and 55% (w/w) of seed-under-leaf. The values were 1796 mM TE/g, 2230 mM TE/g, 355 mg GAE/g, and 177 mg QE/g for DPPH, FRAP, TPC, and TFC, respectively. The greatest contribution of antioxidant activity was shown in that mixture as potential as a functional beverage.
Effect of particle size and loading of cherry tree branch fillers on the mechanical and viscoelastic properties of polypropylene composites
Authors: Öncül Mustafa , Sever Kutlay
Published: January 2025

Lignocellulosic fillers derived from pruned cherry tree branches were studied relative to the mechanical and viscoelastic properties of polypropylene (PP) composites. Tree branches were collected from the orchard after pruning and the wood and bark parts were separated from each other. Both materials were processed into particles of different sizes (below 100 µm and between 100 and 250 µm) and filled into PP at different weight percentages (5%, 10%, 15%, and 20%). The mechanical performances of the biocomposites were evaluated through tensile tests, while their viscoelastic behavior was analyzed using dynamic mechanical analysis (DMA). Results revealed a decline in tensile strength with increasing filler content, which was attributed to poor interfacial adhesion between the PP matrix and fillers. However, tensile modulus increased with increasing filler content, with the highest values were observed at 20% filler loadings. The DMA showed enhanced storage and loss moduli, indicating improved stiffness and energy dissipation. Scanning electron microscopy (SEM) confirmed the presence of voids and filler agglomeration, further explaining the mechanical property reductions. These results demonstrate the potential of cherry tree pruning waste as a bio-filler for sustainable biocomposites with improved stiffness.
Análisis espacio temporal y determinación de la concentración de metales pesados en la laguna Yanamate, Cerro de Pasco, Perú
Authors: Cholan Edison , Menacho Ernesto
Published: January 2025

The Yanamate lagoon was used for acid water discharge from 1981 to 2021, due to the mining activity of the Cerro S.AC mine, located in the province of Pasco, Pasco region. The objective of this research was to analyze the spatio-temporal variation of the water mirror of the Yanamate lagoon and to determine heavy metal concentrations. From Landsat 5 TM, Landsat 7 ETM+, Landsat 8 OLI, Landsat 9 OLI satellite images, the modified normalized difference water index (MNDWI) and the automated water extraction index without shading (AWEI_nsh) were calculated. These indices were used to analyze the spatiotemporal variation of the water mirror surface of the Yanamate lagoon, between the years 1985 and 2022, using the threshold segmentation method. Inductively coupled plasma mass spectrometry (ICP-MS) was used to determine the concentration of heavy metals in the Yanamate lagoon, comparing the concentrations determined with the threshold values of the environmental quality standards (ECA). The spatio-temporal analysis determined an irreversible decrease in the surface area of the Yanamate lagoon's water mirror.  High concentrations of heavy metals were found in water and soil samples analyzed by ICP-MS, exceeding environmental quality standards (ECA). The soils and water analyzed are not suitable for agricultural use or for drinking by animals.
Improvement of reproductive indices in ewes using MAP and eCG hormones
Authors: Mamani-J. I. Jhon , Pérez G. Harold , Fernández R. Eliseo , Rodríguez H. Francisco , Chui B. Heber , Pérez A. Katia , Yabar M. Percy , Roque H. Octavio
Published: January 2025

El objetivo del estudio fue evaluar el efecto del acetato de medroxiprogesterona (MAP) y gonadotropina coriónica equina (eCG) sobre la tasa de fertilidad, natalidad y prolificidad en ovejas criollas en época no reproductiva (anestro: ausencia de celo aparente) en condiciones de crianza familiar en la región Puno ubicada a 3905 msnm. Se utilizaron 40 primerizas y 40 multíparas, a las cuales se colocaron esponjas intravaginales (60 mg de MAP) durante 14 días. Al retiro de las esponjas se administró 500 UI de eCG a la mitad de los animales y las otra 20 quedaron como control (sin eCG). Las ovejas fueron inseminadas vía cervical con semen fresco de carnero Corriedale a las 48 h del retiro de las esponjas. La tasa de fertilidad (preñez) fue de 85 y 57.5% para ovejas con y sn eCG, respectivamente (p<0.001). la tasa de prolificidad en ovejas con y sin eCG fue de 185.3 y 100%, respectivamente. Se concluye que el uso de eCG en el protocolo de sincronización de celo tiene efectos positivos en el aumento de la tasa de natalidad y prolificidad en ovinos en condiciones de comunidades campesinas de la región andina.
Persistencia de anticuerpos maternales contra el virus de Influenza A de campo en porcinos de una granja tecnificada de Lima, Perú
Authors: Quispe Garay Elizabeth , Jurado Pucllas Jessica , Flores Lava Lucero , Navarro Mamani Dennis , Ramírez Velásquez Mercy
Published: January 2025

El objetivo del estudio fue determinar la persistencia de los anticuerpos maternales contra el virus de Influenza A (VIA) de campo en porcinos de una granja tecnificada de Lima. Se identificó una granja porcina multisitios con antecedentes de problemas respiratorios y positiva al VIA por RT-PCR en tiempo real. Se tomaron 342 muestras de sangre de 38 porcinos en 9 periodos de muestreo (21, 35, 55, 72, 85, 102, 117, 131 y 144 días de edad). Se utilizó un kit comercial de ELISA de bloqueo para la detección de anticuerpos contra la nucleoproteína del VIA. Se detectaron anticuerpos derivados de la madre (MDA) en 18.4% (7/38) de los lechones a los 21 días y en 10.5% (4/38) a los 35 días de edad, no detectándose estos anticuerpos desde el tercer hasta el noveno muestreo (55 a 144 días). De los 7 animales seropositivos a los 21 días de edad, 4 continuaron seropositivos en el segundo muestreo.
Modelos de Arquitectura de Big Data para identificar riesgos financieros en los bancos: Una Revisión Sistemática de la Literatura
Authors: Melgarejo-Zelaya Gustavo , Santisteban José , Rivera Luis
Published: January 2025

The financial sector faces difficulties in managing risks due to the increasing volume of structured and unstructured data, which complicates the identification of financial risks such as payment defaults. Traditional models are insufficient to address this problem, prompting the exploration of Big Data solutions. This study aims to review how Big Data architecture models can enhance the prediction and management of financial risks in banks. A systematic literature review was conducted, analyzing 32 relevant studies published between 2019 and 2023. The results indicate that various Big Data frameworks and architectures, such as those utilizing technologies like Apache Spark and Apache Storm, effectively process large data volumes in real-time. Additionally, data analysis techniques like machine learning were highlighted to improve accuracy in risk identification. This study concludes that implementing Big Data and advanced techniques can improve decision-making in financial risk management, although challenges remain in integrating these models into existing banking infrastructures.
Predicción de Fallos Cardiacos usando Machine Learning: Una revisión sistemática de la literatura
Authors: Senmache Ly Jesús Sebastian , Quiñones Nieto Yamil Alexander
Published: January 2025

El desarrollo de la Inteligencia Artificial (IA), hoy está en su auge, y eso despierta el interés de la comunidad científica para hacer estudios usando Machine Learning (ML) una de sus ramas de la IA, que mediante algoritmos o modelos entrenados se puede predecir fallos cardiacos. Según la búsqueda de literatura que se realizó, se encontró que en los estudios se utilizan variables para predecir fallos cardiacos las más utilizadas es la edad, el sexo, la glucosa en ayunas, la presión arterial sistola y el colesterol LDL. Así mismo se realiza un preprocesado de datos, el cual tiene fases y las más usadas son el Reescalamiento, Limpieza de datos, Agrupamiento, Codificación de datos, Detección de valores atípicos. También se ha visto que la mayoría de los estudios proponen sus metodologías y las fases más empleadas son el Preprocesamiento, Aplicación de modelos, Análisis de resultados, Train-test, Clasificación de datos, Selección de modelo o algoritmo.
Invalid Vaccine Doses Among Children Aged 0 to 35 Months: 2011 to 2020
Authors: Albers Alexandria N. , Michels Sarah Y. , Daley Matthew F. , Glanz Jason M. , Newcomer Sophia R.
Published: January 2025

BACKGROUND AND OBJECTIVES

Vaccine doses provided outside the Advisory Committee on Immunization Practices for minimum and maximum ages of vaccination and minimum intervals between doses are considered invalid. Our objective was to quantify the prevalence of and factors associated with invalid doses among US children aged 0 to 35 months.

METHODS

We analyzed provider-verified vaccination records from the nationally representative 2011–2020 National Immunization Survey–Child. We quantified the number of children with at least 1 invalid vaccine dose overall, by survey year, and by vaccine type. Among children who received vaccine doses before the minimum age or minimum dose interval, we quantified the prevalence of receiving extra doses such that series were completed with the recommended number of valid doses. We used logistic regression models to identify factors associated with receipt of an invalid vaccination.

RESULTS

Of 161 187 children, 22 209 (weighted percent: 15.4%, 95% CI, 15.0%–15.8%) had an invalid vaccine dose. Of children with a minimum age or minimum interval invalid dose, 44.9% (95% CI, 43.2%–46.6%) received extra doses and completed the series. The highest prevalence of invalid doses was for 3-dose rotavirus (n = 5733, 4.4%), with the first dose being administered after the maximum age (n = 3996, 3.1%). Overall, the percentage of children with an invalid dose decreased from 2011 (16.9%) to 2020 (12.5%). Children who moved across state lines vs not (adjusted odds ratio: 1.5 [95% CI, 1.4–1.6]) had higher odds of an invalid vaccine dose.

CONCLUSIONS

Although invalid vaccine doses have decreased over time, many children with invalid doses lacked the doses necessary to complete a vaccine series.
Körkép és kórkép a hazai vezetők kompetenciáiról
Authors: Durugy András , Durugy Anna , Szabó Edina , Gál Dóra , Kővágó Pál , Kollár Péter
Published: January 2025

Háttér és célkitűzések: A vezetői kompetenciák vizsgálata alulkutatott terület, a rendelkezésre álló szakirodalom sokkal inkább a vezetői személyiségdimenziókra fókuszál, kevéssé a vezetői kompetenciákra. Hasonlóképpen kevés forrás áll rendelkezésünkre a köz- és versenyszféra vezetőivel kapcsolatosan. Jelen vizsgálatban arra vállalkoztunk, hogy összehasonlítsuk a közép- és felső vezetők, valamint a köz- és versenyszféra vezetőinek kompetenciáit. Feltételeztük, hogy a versenyszféra vezetői nagyobb önállósággal jellemezhetőbbek, míg a közszféra vezetőire inkább végrehajtó kompetenciák jellemzőek. Módszer: Vizsgálatunkban 303 felső és középvezető adatait elemeztük 19 szervezetnél (11 a versenyszférában, 8 a közszférában működik). A vezetői kompetenciák mérésére a CAPTain Analízis & Szubjektív Kompetenciatesztet használtuk, amelynek 11 kompetenciadimenziója mentén hasonlítottuk össze a vezetői szint és a szféra közötti különbségeket. Eredmények: Szignifikáns különbséget találtunk a felső és középvezetők között Önállóság, Vezetői stílus, Delegálás, Befolyásolás, Aktuális vezetői képesség, valamint az Önbizalom kompetenciadimenzióiban. A felsorolt dimenziókban a felső vezetők magasabb pontszámot értek el. Szignifikáns különbségeket találtunk a köz- és versenyszféra vezetői közötti is: a versenyszféra vezetői magasabb Önállóság, Delegálás, Befolyásolás, Aktuális vezetői képesség és Önbizalom kompetencia-pontszámokat értek el, mint a közszféra vezetői. Következtetések: Eredményeink alapján elmondható, hogy a felső vezetőkre jellemzőbb, hogy munkájukat általánosabb irányelvek mentén, magabiztosabban végzik, míg a középvezetők nagyobb igényt mutatnak a konkrét instrukciókra. A versenyszféra vezetőire hasonló profil jellemző, ráadásul párhuzam vonható a versenyszféra közép- és a közszféra felső vezetői között.
Navigating the Competitive Landscape: A Comprehensive Model to Evaluate Competitiveness for Enterprises in Electromechanical Systems Engineerings
Authors: Amer Abdallah D.A. , Korshunova Elena , Saady Wesam Al , Wang Heru
Published: January 2025

The competitiveness of enterprises in the electromechanical systems engineering sector plays a crucial role in driving economic growth and innovation. This study aims to design a comprehensive index for evaluating enterprise competitiveness, focusing on operational efficiency, strategic positioning, and the international environment. Employing an exploratory factor analysis, data was collected through a questionnaire administered to 280 enterprises in Moscow, Russia. The proposed index allows for a dynamic assessment of competitiveness, enabling the analysis of key indicators over time and predicting changes in competitiveness. The findings reveal critical factors contributing to competitiveness in the sector, enabling decision-makers to formulate strategies for improving their competitive position. This research provides valuable insights for policymakers, industry practitioners, and academic researchers in enhancing the competitiveness of electromechanical systems engineering enterprises and fostering sustainable economic development. The study’s contributions to the literature and its practical relevance make it a valuable resource for academic and industry audiences alike.
“Caricature of the 90s” or Parable of Revolution? The Film Narrative about L. D. Trotsky in his 1993 Biopic: the Transition from Repressive Forgetting to Selective Forgetting
Authors:   European University at Saint Petersburg, Fisiukov V. A.
Published: January 2025

The article explores the representation of the pivot points of L. D. Trotsky's biography in his biopic of 1993 – the first Russian fiction film dedicated to the fate of the once “enemy № 1”. With the help of G. Korte's film analysis methods, the author highlighted narrative features and visual images in the film. Then on the material of reviews the ways of decoding the meanings contained in it are summarized, and on the basis of interviews of the film's creators their vision of the film is determined. A. Assman's conceptual apparatus is used to analyze the obtained results: forms of repressive forgetting, i.e., destruction of references to a person or event, and selective forgetting, selective remembrance of the past, natural for any society. The historical inaccuracies of the film narrative are accounted for as derivatives of the technique of “palimpsest” – symbolic rewriting generated by interpretations and reinterpretations of past events. Themes not presented or weakly articulated in the film are seen as manifestations of “covert silence” (V. Vinitzky-Seroussi & C. Teeger). The author concludes that the methods of constructing images and clichés in the representation of L. D. Trotsky, highlighted in the film narrative, partially “normalize” him as a historical figure and allow us to call the film an element of the transition to selective forgetting.
The Concept of Great Power at the Service of the Revived Cossacks
Authors:   European University at Saint Petersburg, Kamentsev A. A.
Published: January 2025

The idea of great power is central for the self-identification of the contemporary Cossacks' majority, building up a scheme: the revival of the Cossacks contributes to the revival of Russia as a great power, which lost this status as a result of the collapse of the USSR. A significant part of neo-Cossacks since the early 1990s have defined their essence through the idea of serving the Fatherland, which by default should be great, implying military and political power. At the same time, a part of Cossack nationalists had a negative attitude to the mandatory involvement of the Cossacks in state service, promoting only ethno-cultural revival with possible local autonomy and criticizing the imperial great-power aspirations of the other part of the Cossacks. However, it was the model of state patriotism that proved to be the most stable, supported by the authorities and dominating the public discourse.
Social network for guardians of transgender children and adolescents
Authors: Abreu Paula Daniella de , Valença Ana Beatriz Marques , Leal Gilberto da Cruz , Silva Diogo Henrique Mendes da , Palha Pedro Fredemir , Araújo Ednaldo Cavalcante de , Ballestero Jaqueline Garcia de Almeida , Almeida Sandra Aparecida de , Nogueira Jordana de Almeida , Monroe Aline Aparecida
Published: January 2025

ABSTRACT Objective To analyze the social network of mothers, fathers or guardians of transgender children or adolescents. Methods This was a qualitative study, based on the theoretical framework of social network, with a focus on the primary network. The study was conducted in Brazil through online interviews between August and October 2021. A total of 30 mothers, two fathers and one grandmother of transgender children or adolescents participated in the study. The thematic content analysis was performed using IraMuTeQ software. Results The theme “The family as the center of the network and the challenges in achieving transgender autonomy” emerged from the analyses. The family was identified as the first network, bearing the greatest responsibility. Weak and conflicted ties with relatives, friends, classmates and neighbors, highlighting the role of men. Conclusion The networks showed limitations in providing support and the need for strengthening. The analysis is an important tool for improving care, structuring policies and developing transgender-specific care pathways.
Pessoas trans e travestis em situação de rua em Salvador: estudo descritivo sobre o perfil sociodemográfico e de acesso aos serviços socioassistenciais e de saúde, 2021 e 2022
Authors: Dias Wiler de Paula , Nunes Thayane Silva , Nascimento Igor Myron Ribeiro , Abade Erik Asley Ferreira , Dultra Lua Sá , Marinho Milena Lemos , Ribeiro Guilherme de Sousa , Nery Joilda Silva
Published: January 2025

RESUMO Objetivo Descrever o perfil sociodemográfico e de acesso aos serviços socioassistenciais e de saúde entre pessoas trans e travestis em situação de rua em Salvador. Métodos Trata-se de estudo transversal com 24 (4,5%) participantes que se autoidentificaram como pessoas trans ou travestis do total de 529 pessoas, com idade igual ou superior a 18 anos, presentes em logradouros públicos ou unidades de acolhimento institucional incluídas no inquérito. Os dados foram coletados entre 2021 e 2022, por meio de questionários estruturados. Resultados Chegou-se à amostra majoritariamente composta por mulheres trans e travestis (n=18), jovens (n=13), negras (n=22), solteiras (n=18) e com ocupações informais (n=23), nas quais relataram sofrer violência (n=17). Foram encontradas dificuldades de acesso aos serviços de saúde e socioassistenciais frequente (n=15), devido à ausência de documentação, demora no atendimento e discriminação social/racial. Conclusão Observa-se a vulnerabilização acentuada de pessoas trans e travestis em situação de rua, submetidas a múltiplas formas de discriminação e exclusão social.
Design optimisation and performance evaluation of single and multiple tuned mass dampers controlling multiple degrees of freedom structures
Authors: Allani Anissa , Bel Hadj Ali Nizar
Published: January 2025

Structures with high flexibility and low inherent damping are susceptible to dynamic excitations such as traffic, wind and earthquakes. To ensure their stability, vibration control systems such as tuned mass dampers (TMDs) are used to reduce excessive vibrations. In this paper, a novel numerical optimisation criterion is proposed for identifying the appropriate TMD parameters, specifically stiffness and damping, to improve vibration attenuation. The first part focuses on the optimisation of single TMDs, where the proposed numerical criterion is compared with three established optimisation approaches from the literature. The optimum analytical parameters of three approaches for single degree of freedom (SDOF) structures are extended to multiple degrees of freedom (MDOF) systems through modal transformation. Results show that the proposed criterion takes into account the main structure’s higher modes, enabling reduction of the total response instead of targeting a single mode's response. The second part extends the analysis to multiple TMDs for MDOF systems. Results show that using multiple TMDs enhances the ability to tune frequencies to different structural vibration modes, significantly improving energy dissipation and vibration control. The performance of optimally tuned multiple TMDs was assessed with real earthquake records, showing their effectiveness in dissipating energy and reducing vibrations.
Determination of insecticide resistance levels of Leptinotarsa decemlineata (Say, 1824) (Coleoptera: Chrysomelidae) in potato fields of Niğde, Konya, and Afyonkarahisar provinces
Authors: Mülayim Orhan , Çetin Hüseyin
Published: January 2025

In our research, acetamiprid, spinosad, and deltamethrin resistance levels were determined in Leptinotarsa decemlineata (Say, 1824) (Coleoptera: Chrysomelidae) populations collected from two different locations in potato cultivation areas of Niğde, Afyonkarahisar, and Konya provinces, where 34.8% of the amount was produced. The insecticides were applied using a spray tower at different concentrations. 3-4th instar larvae were subjected to residual effect tests. The susceptible population was obtained from Niğde Ömer Halisdemir University. Field populations were collected starting from June 2023. In the residual effect tests, at the end of the 24-hour exposure period, the LC50 values obtained from the susceptible population, Sandıklı, Şuhut, Konaklı, Çiftlik, Çumra, Selçuklu populations were determined as 1.507, 111.964, 89.617, 81.977, 73.563, 38.062, 7.409 mg ai l-1 for acetamiprid; 1.105, 21.035, 16.218, 11.982, 15.841, 8.183, 8.945 mg ai l-1 for deltamethrin and 4.738, 104.224, 96.404, 70.211, 64.147, 56.863, 37.639 mg ai l-1 for spinosad, respectively. The highest resistance rate was detected in the Sandıklı population as 74.30-fold, 19.04-fold, and 22-fold for acetamiprid, deltamethrin, and spinosad, respectively. Considering insecticide resistance, it is important to give priority to insecticides to which the pest has developed less resistance in chemical control of L. decemlineata.
Abundance and diversity of natural enemies of aphids (Hemiptera: Aphidomorpha) on different host trees in forest habitats
Authors: Oğuzoğlu Şükran , Avcı Mustafa
Published: January 2025

Forests are ecosystems with high biological diversity, where various groups of organisms live. In the province of Isparta, during the years 2019-2020, systematic sampling in forest areas yielded data on aphids and their natural enemies. The tree species studied included [Pinus nigra Arnold. subsp. pallasiana (Lamb.) Holmboe., Pinus brutia Ten., Cedrus libani A. Rich., Abies cilicica (Antoine & Kotschy) Carrière (Pinaceae), Juniperus spp. (Cupressaceae), Quercus spp. (Fagaceae), and Robinia pseudoacacia L. (Leguminosae)]. The study identified 34 aphid species and 42 natural enemy species across 14 host tree species. The distribution of these species among orders was as follows: 54% Coleoptera, 15% Neuroptera, 13% Hemiptera, 13% Hymenoptera, 3% Diptera, and 3% Raphidioptera. The most abundant natural enemy species were Oenopia lyncea (Olivier, 1808) (19.0%), Harmonia quadripunctata (Pontoppidan, 1763) (11.3%), and Adalia decempunctata (L., 1758) (9.2%) in 2019 and H. quadripunctata (14.3%), Coccinula quatuordecimguttata (L., 1758) (12.5%), and Hippodamia variegata (Goeze, 1777) and Stethorus gilvifrons (Mulsant, 1850) (8.9%) in 2020. The tree species with the highest number of aphid species were P. nigra (15 species) and C. libani (13 species). In total, 123 interactions were identified among the 34 aphid species and 42 natural enemy species across 14 host tree species, representing tri-trophic levels.
Determination of plant-parasitic nematode fauna and evaluation of soil quality in apple orchards of Çanakkale province (Türkiye)
Authors: Arslan Enes Ceyhun , Gözel Uğur
Published: January 2025

In September 2023, a total of 130 soil samples were collected from five different districts in the province of Çanakkale (Türkiye) and its surroundings to identify plant-parasitic nematode communities in apple orchards and to create distribution maps of these species. The density and distribution of nematode communities were examined. In total, 14.090 nematode individuals were analyzed, and 30 genera were identified. The nematodes were classified into six different orders, with the order Rhabditida standing out as the most dominant (53.87%). The order Tylenchida ranked second (23.22%). Among the most common plant-parasitic nematodes identified in the study were Paratylenchus spp. Micoletzky, 1922 (Tylenchida: Tylenchulidae) (3.46%), Merlinius spp. Siddiqi, 1970 (Tylenchida: Dolichodoridae) (3.36%), and Pratylenchus spp. Filipjev, 1936 (Tylenchida: Pratylenchidae) (3.02%). The results of the study indicate that the c-p 2 group is prevalent under disturbed soil conditions, and the dominance of the p-p 2 and p-p 3 groups poses a significant threat to apple orchards. These findings highlight that nematode c-p series are important bioindicators in the assessment of soil quality, and such analyses should be expanded through regional studies.
Influence of intestinal dysbiosis on the course of authistic spectrum: literature review
Authors: Grigoryants E. O. , Chervinets Yu. V. , Chervinets V. M. , Rumyantseva E. S.
Published: January 2025

The article presents a review of studies elucidating the mechanisms by which the gut microbiota, its metabolites, and the brain interact to influence the pathogenesis and clinical presentation of autism spectrum disorders. A deeper understanding of gut-brain axis interactions could provide the basis for new therapies aimed at alleviating symptoms in children with autism spectrum disorders.
Microorganisms and peculiarities of the course of the postoperative period in patients with infective endocarditis and COVID-19
Authors: Petrova O. V. , Tverdokhlebova D. K. , Shashin S. A. , Nikulina D. M. , Kolesnikov V. N.
Published: January 2025

In patients with infective endocarditis, the type and genus of microorganisms influence the course of the postoperative period. Objective – to study the structure of microorganisms isolated from blood in patients with acute infective endocarditis associated with COVID-19 and its relationship with the development of early postoperative complications. We retrospectively analyzed the case histories of 14 patients (11 men and 3 women) with acute infective endocarditis associated with COVID-19. On admission to the hospital, all patients underwent 3-fold blood sampling for microbiological studies, which were performed on bacteriological analyzers. The frequency of microorganisms’ isolation amounted to 28.57 %. The detected pathogens were represented by Gram-positive (Enterococcus faecalis) and Gramnegative bacteria (Klebsiella pneumonia and Escherichia coli). In all patients with isolated microflora the postoperative period was complicated by pneumonia and sepsis against the background of progressive cardiac and respiratory failure, its outcome was unfavorable. When comparing our own data with literature data, it was found that the frequency of microorganism’s isolation in our patients was 28.57 %, in foreign authors – 100 %; gram-positive and gram-negative bacteria were isolated in our patients, in foreign literature – gram-positive bacteria; in our patients with positive culture in 100% of cases the postoperative period was unfavorable, in foreign authors – in 40 % of cases.