bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular genotypic detection of beta human papillomavirus DNA in the diagnosis of their association with certain skin epithelial neoplasias in immunocompromised and immunocompetent patients in the mode Real-Time
Authors: Korneva Lyubov V. , Snarskaya E. S , Nodelman E. K
Published: September 2020

Epidemiological and molecular biological data suggest that the beta human papillomavirus (HPV) can cause the development of a number of epithelial skin tumors, but this interconnection is currently not fully understood. Besides detection of beta HPV, it is necessary to measure and quantify the viral load, it is a new approach in the diagnosis of HPV infection. 52 patients were examined to identify the association of epithelial neoplasias beta human papilloma virus in immunocompromised and immunocompetent patients in the department of chronic hemodialysis and kidney transplantation of Moscow Regional Research and Clinical Institute. HPV detection was performed by polymerase chain reaction (PCR) with hybridization-fluorescence detection in real time (Real-Time). Amplification and detection were performed on the tool Rotor-Gene 3000 (“Corbett Research”, Australia). For quantification of beta HPV recombinant plasmid positive controls, as well as control plasmidfragment offi-globin human gene (FSIS CRIE Rospotrebnadzor) were used. In fibroepithelial polyp and in apparently healthy skin of immunosuppressive patients - renal transplant recipients (RPT) with a high frequency was detected beta HPV DNA - 64 and 54%, respectively, compared to healthy skin (47% of cases). In fibroepithelial polyp in 57% of immunosuppressive RPT mixed infection was revealed. Viral load in the fibroepithelial polyp was higher than that as in apparently normal skin and in donors skin. The high detection ofHPVDNA in RTP, as in the fibroepithelial polyp and in apparently healthy skin was found. Immunocompetent patients had high HPV DNA detection only in fibroepithelial polyp compared with apparently healthy skin.
Treatment of chronic spontaneous urticaria with high doses of antihistamines
Authors: Kosoukhova Olga A. , Kochergin N. G , Kolkhir P. V
Published: September 2020

Urticaria is a group of diseases, the main clinical symptoms of which are transient rashes characterized not only by itch but skin edema, erythema, arising in any area of the skin, andfull resolution up to 24 hours. Urticaria is observed at least once in life of the 15-25% of the population, 25% of this patients have the chronic form of the disease. The aim of our work was the optimization of treatment of chronic urticaria by the second-generation antihistamine levocetirizine in standard and high daily dosages (up to fourfold), the study of clinical, allergo-logical and immunological characteristics of the results. The study involved 60 patients between the ages of 18 to 73 years with confirmed clinical diagnosis of chronic urticaria. The study was conducted in the clinic of skin and venereal diseases of I.M. Sechenov First Moscow State Medical University. Clinical and anamnestic examination, laboratory tests, autologous serum skin test were performed. The study was conducted within 1 month and included diagnostic consultation period and 5 consultations every 7 days. The obtained data were used to generate optimized approaches to the treatment of patients with chronic urticaria with regard to the form and severity level of the disease. Optimally assigned differentiated dosages of antihistamines, based on individual performance autologous serum skin test and severity of the clinical picture of urticaria, equally lead to a reduction of clinical severity and improve quality of life of patients with chronic urticaria.
Clinical case scleroderma associated with Borrelia infection
Authors: Tarasenko Grigoriy N. , Bobrov A. N , Bogdanova T. V , Protiuc Oksana
Published: September 2020

Clinical case of skleroderma, associated with borrelia infection is presented. 64 year old patient complained about lesions on the skin of the trunk, in the form of consolidation with change of colour and shine. 5 years ago on a skin in the left calcaneal area stuck tick that has been independently removed, was found. First occurrences of dark stains on a trunk was noticed a year ago. On the basis of the anamnesis, clinical picture and histologic research the diagnosis of localized skleroderma was established. Successful treatment was performed.
PUVA AND INTERFERON Α COMBINED THERAPY IN PATIENTS WITH MYCOSIS FUNGOIDES
Authors: Olisova O. Yu , Smirnov K. V , Grekova Ekaterina Vladimirovna
Published: September 2020

The results of mycosis fungoides (MF) treatment using therapy that combines interferon α (IFNα) and PUVA-therapy are presented. We observed 16 patients with MF. The diagnoses were verified with histological, immunohictochemical methods and molecular analysis. The response to treatment was defined by the index of the modified assessment of the severity of skin lesions scale (mSWAT). In addition, the safety and tolerability of IFNα and PUVA-therapy were evaluated. In terms of the stage of the disease, patients were distributed as follows: IB-IB - 1 (6%), IIA - 3 (19%), IIB - 6 (38%), IIIA - 2 (12.5%), IIIB - 1 (6%), IVA - 2 (12.5%), IVB - 1 (6%). PUVA-therapy was performed four times a week with the initial dose of the irradiation 0.5-1.0 J/cm2. The course of therapy consisted of 40 ± 8 procedures. The total dose was 157 ± 45 J/cm2.IFNα was prescribed to patients (3 IU three times a week). The total dose was 96 ± 31 IU. After the therapy 12 (75%) patients with stage IB-IIIA, mSWAT index was reduced by 90-100%, which corresponded to complete clinical remission in the form of the disappearance of cutaneous manifestations and subjective sensations. 3 (19%) patients with stage IIIB-IVA had mSWAT index decreasing from 50 to 75%, i.e. partial remission was observed as decrease of the injury area and rash brightness, reduce scaling, itching. 1 (6%) patient with stage IVB had no effect of the therapy. Studies have shown that PUVA-therapy in combination with interferon α can be successfully used at patients with MF, regardless of the disease stages, however, more positive effect was in patients with stage IB-IIB MF.
CICATRICIAL PEMPHIGOID: AN INTERDISCIPLINARY PROBLEM
Authors: Tarasenko Grigoriy N. , Gladko V. V , Sysoeva A. N , Sviderskaya O. S , Kuzmina Yu. V , Tokmakova A. N
Published: September 2020

Clinical case of patient with rashes on mucous membrane of oral cavity with severe pain, edema, redness, deformation of eyelids on both eyes and decreased visual acuity is presented. After examination by several specialists (dentist, ophthalmologist and dermatologist) cicatricial pemphigoid with primary lesion of eyes was diagnosed. Authors point out doctors on danger of serious complications of this disease, which demand active involvement of doctors of other specialties.
TRUE ACANTHOLYTIC PEMPHIGUS FROM THE STANDPOINT OF PSYCHOSOMATIC MEDICINE: A REVIEW OF THE LITERATURE
Authors: Dorozhenok I. Yu , Teplyuk N. P , Katranova Daria G.
Published: September 2020

Today the problem of correlation of mental disorders and skin diseases is relevant in Russia. Psychosomatic disorders, comorbid true acantholytic pemphigus (pemphigus) and cases of affective disorders are described on this literature review. The relationship between manifestation and exacerbations of pemphigus with psychogenic disorders is shown. Studies investigating quality of life of patients with pemphigus are described. The literature was searched in the following databases: MedLine, PubMed, Concilium Medicum, SCOPUS, Web of Science, LILACS, PEPSIC, Russian State Library, the Sechenov central science medical library.
EXPERIENCE OF THE LONG-TERM USE OF ANTICYTOKINE THERAPY IN PSORIASIS
Authors: Kovtunova Violetta A. , Dumchenko V. V , Bakhmutova E. G , Tkachenko T. A , Yanchevskaya E. Yu , Mesnyankina O. A
Published: September 2020

Increasing the effectiveness of treatment and restoring the quality of life in patients with moderate to severe and severe forms of psoriasis is one of the most important trends in modern dermatology. The appearance of biological products in the late XXth century opened new opportunities in the treatment and control of the course of the disease in patients suffering from moderate and severe forms of psoriasis. Conducting maintenance system treatment with biological products reduces the severity of course of dermatosis, and in some cases prevents the occurrence of disease relapses. Despite the increasing popularity of anti-cytokine drugs, there are difficulties in the treatment of choice of the therapy in some cases. Among the main reasons for the lack of response to ongoing biological therapy are the genetic characteristics of the patient and the immunogenicity of the drugs. Failures in the use of biological therapy can also result a low concentration of the drug before the next administered dose. It has been proven that the combined use of methotrexate and infliximab inhibits the development of anti-drug antibodies that are associated with the development of a low therapeutic response. The article describes the clinical observation of a patient suffering for 20 years from a severe form of psoriasis and psoriatic arthritis. The experience of long-term (about 10 years) prescription of the biological preparation infliximab with sufficient clinical response without additional use of methotrexate is shown. The results of successful combined therapy of psoriatic erythroderma and psoriatic arthritis with infliximab and acitretin in order to reduce the immunogenicity of the tumor necrosis factor α blocker and avoid the ”escape” effect are described. The data of restoration of a good therapeutic response to systemic biological therapy with infliximab after administration of acitretin are presented.
MODERN VIEW OF THE ETIOPATHOGENESIS AND CLASSIFICATION OF ACNE SCARRING
Authors: Ostretsova Mariya N.
Published: September 2020

Acne vulgaris is a common chronic skin disease involving blockage and inflammation of pilosebaceous units. It has a genetic predisposition and sharply reduces the quality of patients’ life and the level of their social adaptation through the formation of conspicuous cosmetic defects in open areas of the skin. The processes of pathological scarring (atrophic, hypertrophic and keloid scars) is described in detail as one of the most severe consequences of acne vulgaris and its treatment. The problem is described from the modern point of view of the pathogenesis of acne vulgaris. Differential diagnosis between keloid and hypertrophic scars, as well as the most relevant approaches to classification and evaluation of severity of postacne scarring according to the valid international scales, are presented.
PSORIASIS IN HIV-INFECTED PATIENTS: CLINICAL AND LABORATORY EVALUATION, APPROACHES TO THERAPY
Authors: Evdokimov Evgeny Yu. , Sundukov A. V
Published: September 2020

Clinical and laboratory evaluation of the effectiveness of therapy of psoriasis vulgaris in 78 HIV-infected patients using the two treatment regimens is presented. Peculiarities of clinical course of psoriasis depending on the number of CD4+lymphocytes in the peripheral blood are shown. Histological and histochemical studies of biopsy samples from psoriatic skin lesions and apparently healthy skin in 15 people were performed. The dynamics before and after treatment of CD4+ and CD8+ lymphocytes in biopsies of skin and blood, their relationship with the index of severity of psoriasis (PASI) are presented. This study is of theoretical and practical interest in understanding the value and role of CD4+ and CD8+ lymphocytes in the formation of inflammatory reactions in the skin of patients with psoriasis as a possible option for treatment of psoriasis in HIV-infected patients.
PSORIASIS IN PATIENT WITH VITILIGO
Authors: Dubensky V. V , Nekrasova Elizaveta G. , Muraveva E. S , Alexandrova O. A , Gutyanskaya E. Yu
Published: September 2020

The case report of a rare form of combined autoimmune diseases in patient with psoriasis vulgaris (plaque form), non-segmental vitiligo and autoimmune thyroiditis was presented. This case may be of interest to dermatovenereologists, since it is an example of rare-associated dermatoses.
GLYCATION STRESS AND PHOTOAGING OF THE SKIN
Authors: Vavilova Ada A. , Gubanova E. I , Gladko V. V
Published: September 2020

The study of foreign researchers on glycation mechanisms and the effect of this non-enzymatic reaction on photodamaged skin are presented. The final products of enhanced glycation - AGEs and their pathogenetic role in skin aging are described. AGEs inhibiting substances, focusing on the prevention of the glycation process, are described.
NONNEOPLASTIC HYPERPIGMENTATION OF THE SKIN: MODERN VIEWS ON METHODS OF CORRECTION
Authors: Kruglova L. S , Ikonnikova Evgeniya V.
Published: September 2020

A brief literature review of the main methods of treatment of hyperpigmentation on the basis of modern scientific publications is presented. The overview reflects the main trends in the use of external treatment, laser and light therapy, and the possibility of a combination of some methods of treatment.
SKIN B-CELL LYMPHOMAS: 20 YEARS EXPERIENCE IN OBSERVATION AND TREATMENT
Authors: Lamotkin I. A , Rukavitsyn A. O , Gladko V. V , Tarasenko G. N , Volgin V. N , Tarasenko Yu. G
Published: September 2020

Authors observed 18 patients with cutaneous B-cell lymphomas (B-CLS): primary cutaneous follicle center lymphoma (PCFCL) (44,45%), primary diffuse large B-cell lymphoma (B-CLL) (44,45%), cutaneous marginal zone B-cell lymphoma (CMZL) (11,1%). Features of cutaneous marginal zone B-cell lymphoma are: appearance of multiple spots; identification of diagnosis in stages T2aN0M0; treatment - excision or laser destruction; frequent recurrence do not affect prognosis. Features of primary cutaneous follicle center lymphoma are: appearance of single node; identification of diagnosis in stages T1aN0M0 and T2aN0M0; treatment - excision, can be also combined with radiotherapy. Features of primary diffuse B-CLL are: appearance of multiple spots; identification of diagnosis in stages T3bN0M0, T1aN1M0 and T2bN2M0; disease is aggressive; treatment is a local radiotherapy, interferon alpha intralesional, chemotherapy according to schemes CHOP, COP and R-CHOP, photodynamic therapy is possible.
CHRONIC ACTINIC DERMATITIS AND PATHOLOGY OF THE DIGESTIVE TRACT
Authors: Konnov Pavel E. , Orlov E. V
Published: September 2020

Chronic actinic dermatitis (CAD) is characterized by itchy eczematous lesions on areas of skin exposed to sunlight. The disease affects men middle-aged and elderly. Three criteria was taken into account to diagnose CAD: the effects of the minimum erythemal doses of UVA and UVB, a persistent eczematous lesions in areas exposed to radiation and sometimes non-irradiated sites, and histopathological changes resembling chronic eczema. The eczematous process of the skin develops as a result of a number of factors that lead to sensitization of the organism, including in the pathology of the digestive tract and the hepatobiliary system. A correlation was found between the severity of eczematous skin lesions and the severity of the digestive tract disease. Material and methods. Under the care of the Department of dermatology and venereology Clinics of the Samara state medical University of Minzdrav of Russia were 65 men with CAD, among them 61 (93.9%) patients are over 40 years old. The pathology of the digestive tract and the hepatobiliary system was detected in 51 (78.6%) patients. Concomitant diseases of the digestive tract and the hepatobiliary system had a latent period and were identified for the first time due to a comprehensive survey in 37 (57%) patients. Results. In most cases, CAD on the background of the digestive system disease, there was a moderate and severe course of the eczematous process. The frequency of occurrence of reflux esophagitis, superficial and atrophic gastritis, duodenogastric reflux, as well as the combined pathology of the hepatobiliary system was maximal in patients with the most severe course of the eczematous process. The majority of patients without pathology of the digestive tract and hepatobiliary system had minimal skin manifestations of eczema.
USE OF AUTOLOGOUS PLATELET-RICH PLASMA WITH THROMBOCYTES IN DERMATOCOSMETOLOGY (REVIEW)
Authors: Karagadyan Ania D.
Published: September 2020

The literature review on use of the autologous platelet-rich plasma (auto-PRP) in dermatocosmetology is presented. The use of PRP is a very perspective method of correction of cosmetology problems associated with involutional skin changes, as well as in the treatment of dermal diseases, such as alopecia, psoriasis, eczema, palmar and plantar warts, photodermatoses, acne, cankers of the lower extremities, vitiligo and rosacea. The strategy of PRP use is to improve and accelerate the processes caused by the stimulating growth factors contained in platelets.
Subcorneal pustular dermatosis of Sneddon-Wilkinson: Сlinical case
Authors: Karacheva Yu. V , Smykova Anastasia Nikolaevna
Published: September 2020

A review of the etiology, pathogenesis, clinical manifestations and histological characteristics of a rare skin pathology -- dermatosis of the subcorneal pustular Sneddon-Wilkinson, is presented. The difficulties of differential diagnosis of this disease with pustular psoriasis, dermatitis herpetiformis Duhring, pyoderma and others are shown. A description of the clinical case of subcorneal pustular dermatosis Sneddon-Wilkinson in a man of 54 years is presented.
CLINICAL ASPECTS AND ALGORITHMS DIAGNOSTICS OF DIFFERENT TYPES OF ERYTHRODERMA
Authors: Olisova O. Yu , Zaslavsky D. V , Sidikov A. A , Chuprov I. N , Wenzel J. , Grekova Ekaterina V.
Published: September 2020

Erythroderma - the term used for the description intensive and usually widespread reddening of the skin which has arisen owing to activation of the previous inflammatory dermatosis. The aim is to study and compare clinical manifestations of various forms of an erythroderma and also to develop an algorithm of their diagnostics and therapy. We observed 133 patients with an erythroderma undergoing investigation and treatment on bases of dermatologic depatments: V.A. Rakhmanov Clinic of skin and veneral diseases I.M. Sechenov First Moscow State Medical University, Leningrad Regional centre of specialized types of a medical care, Skin-Venerologic Clinic of St. Petersburg and university clinic Bonn the period from 2001 to 2018. A prospective study was conducted at 51 patients, is retrospective - at 82 patients. From them were men - 83 persons and women - 50 people, whose average age was 49 years (in the range 26-85 years). The collecting of the anamnesis is carried out; clinical data are studied and for verification of the diagnosis are compared with results of a histological research. Clinical manifestations of all surveyed groups were similar. The most frequent symptoms were generalized reddening and a peeling of the skin, an itch of skin, different degree of expressiveness and a form of changes of nail plates, changes of palms and soles. Diagnosis on the basis of only clinical examination gave the chance to make the correct diagnosis in 77(58%), in comparison with the final diagnosis 112(84,1%) from 133 made on the basis of set of clinical, histological data and reaction to therapy. In particular, the diagnosis of a psoriatic erythroderma was made in 26(34,58%) from 133, an atopic eythroderma - 20(26,6%), the eythroderma caused by reception of drugs - 24(31,92%), an erythrodermic form of mycosis fungoides/Cezary syndrome - 7(9,31%) from 133 patients. The clinical diagnosis didn’t correspond to the final diagnosis in other 56(42%) from 133 patients. Thus, at diagnosis and definition of forms of an erythroderma important aspect is clinical examination and clinicopathologic correlation.
INCIDENCE OF PSORIASIS DEPENDING ON THE REGION OF THE RUSSIAN FEDERATION
Authors: Gudinova Zh. V , Okhlopkov V. A , Poleshchuk Ekaterina Ivanovna , Zhernakova G. N
Published: September 2020

The article presents the results of a study on assessment the differences of psoriasis incidence in adults in regions of the Russian Federation. The indicators of general and primary incidence of psoriasis were used as the material for a study according to the data from Central Research Institute of Health Organization and Informatics of the Ministry of Public Health of the Russian Federation for the period 2009-2013. The comparative results of psoriasis prevalence among adults population in various regions in Russia were presented. Higher incidence rate was detected in the northern and northeastern regions of the North-Western, Volga, Ural, and Far Eastern regions. The results of classification for the regions of the Russian Federation according to the data of primary and general morbidity were presented. In order to establish the peculiarities of pathology formation and assess the quality of information in the regions of the Russian Federation, a multidimensional classification of the incidence of psoriasis was carried out using the cluster analysis method, using the comparison of prevalence (general morbidity) with primary incidence data for the period 2009-2011. As a result of the cluster analysis, four classes of the country regions are distinguished, the differences between which are statistically significant for all classification characteristics. The average indices of both primary incidence and prevalence of psoriasis are registered in regions of Class 1 (27 subjects of the Russian Federation). The minimum indices of primary and general incidence of psoriasis were noted in class 2 (24 subjects of the Russian Federation), which comprised regions predominantly of the Central, Southern, Siberian FD. The highest rates of primary incidence and prevalence of psoriasis were found in the group of regions that made up Class 4 (14 subjects of the Russian Federation), in a third of the regions of this class - Orel and Sverdlovsk regions, Udmurt Republic, Komi Republic and Sakha (Yakutia), data, unsatisfactory dispensary observation of patients with psoriasis. A certain decrease in the availability of specialized dermatological care can be expected in Class 3 regions, where the primary incidence is low, and the prevalence is above the average (18 subjects of the Russian Federation).
Melanocortin 1 receptor MC1R as a genetic factor in the development of psoriasis
Authors: Galimova Elvira S. , Kõks Sulev , Kingo Külli , Khusnutdinova E. K
Published: September 2020

The CRH-POMC system in the skin coordinates pigmentation and the immune response. We performed the association study of single-nucleotide polymorphism SNPs of MC1R gene in a cohort ofpsoriasis patients of Tatar ethnic group from the Volga-Ural region of Russia. The results suggest that polymorphisms of the MC1R gene may contribute to the protection or development of psoriasis in Tatar population.
Modern trends in repeated disability due to diseases of the musculoskeletal system and connective tissue in retirement age citizens of the Russian Federation
Authors: Shurgaya Marina A.
Published: September 2020

The article presents results of the study ofproblems of the repeated disability due to diseases of the musculoskeletal system and connective tissue in retirement age citizens of the Russian Federation in the period of from 2005 to 2014. There were analyzed the number of this category of invalids, their specific weight among re-recognized as disabled cases with account of classes of diseases and the age, structure of the repeated disability in groups, the level of repeated disability and ranking places of subjects of the Russian Federation on this index in 2014. The results of the executed analysis indicate that only in the Russian Federation for 10 years (2005-2014) there were re-recognized as disabled due to diseases of the musculoskeletal system and connective tissue 487.1 thousand people from citizens of retirement age with distinct dynamics of the increase as their absolute number (from 22.1 thousand persons in 2005 to 69.3 thousand people in 2014) and the index of disability level (respectively from 7.6 to 20.5 per 10 thousand of the corresponding adult population). This pathology was established to determine a high level of repeated disability in this age group (20.5 per 10 thousand population). Comparative analysis by age revealed that in the Russian Federation in the structure of the repeated disability due to diseases of the musculoskeletal system and connective tissue in the adult population invalids of the retirement age prevail (42.8% in 2014). Along with diseases of the circulatory system (of rank 1) and malignant neoplasms (rank 2), diseases of the musculoskeletal system and connective tissue form the contingent of cases repeatedly recognized as disabled of retirement age (3th rank place). A ranking ofall subjects of the Russian Federation by the level of repeated disability of citizens of retirement age due to diseases of the musculoskeletal system and connective tissue allowed to select 70 ranking places, that with bearing in mind the present demographic situation, has a practical orientation for planning the organization of medical and social care for the given large category of the population.
The application of electrical myostimulation for the purpose of neuro-rehabilitation
Authors: Baklushina E. A , Yastrebtseva I. P
Published: September 2020

We undertook the review and analysis of the current literature publications of the leading national scientific schools and theforeign authors concerning the application of electrical myostimulation for the purpose of neuro-rehabilitation of the patients presenting with the stroke-associated locomotor disorders. The method is based on the electrical stimulation of the nerves and muscles by means of the application of a current with the pre-determined characteristics from the myostimulator through electrodes to the human body. The current thus triggers the sanogenetic mechanisms of the organism and thereby promotes the restoration of the lost function. At present, there is no universally accepted algorithm for the application of stimulation therapy. Therefore it was deemed appropriate to describe various approaches to the use of the above method together with the conflicting results obtained with the help of electrical myostimulation.
Physical rehabilitation of the patients during the early postoperative period after coronary artery bypass surgery
Authors: Bazylev V. V , Gal’tseva N. V
Published: September 2020

The purpose of the study. To estimate efficacy and safety of controlled cardio workouts on a treadmill in the early postoperative period for patients, who underwent coronary artery bypass surgery (CABS). Materials and methods. In the study there were109 patients having coronary artery disease and preserved systolic function of the left ventricle, who underwent coronary artery bypass surgery. The first group consisted of 59 patients who underwent not only standard cardiac rehabilitation activities in the early postoperative period, but also controlled cardio workouts on a treadmill. The second (control) group consisted of 50 patients with standard activities of physical rehabilitation. Cardio workouts with intensity of 3-6 MET were carried out on a running track before discharge of a patient from hospital, starting on the third-fourth day after surgery. At the same time thorough monitoring of blood pressure (BP), heart rate (HR), ECG were performed. At the end of the stationary phase of physical rehabilitation the patients in both groups filled the questionnaire «SF-36 Health Status Survey». The results. Initially, according to clinical and demographic and perioperative characteristics the compared groups did not differ authentically. At the end of the program of physical rehabilitation for the average value of the total post-operative bed day in the first (8,14 ± 0,99) and the second group (9,22 ± 1,64) statistically significant differences were obtained (р
Physical and rehabilitative medicine: fundamental principles and clinical practice
Authors: Ponomarenko Gennadiy Nikolaevich
Published: September 2020

This article was designed to present an overview of experimental and clinical studies making up a basis for the formulation of the fundamental principles of physical medicine. The analysis of the fundamental mechanisms of sanogenesis underlying medical rehabilitation has been undertaken which allowed to define the main lines of scientific and practical developments in physical and rehabilitative medicine as a new field of practical medicine concerned with the action of physical methods and factors on the human body when applied for the treatment and medical rehabilitation of the diseased and disabled subjects. The basic methodological approaches to this work are substantiated in the context of modern personalized and evidence-based medicine taking into consideration the totality of the currently available rehabilitative technologies and the prospects for their further development and introduction into the existing healthcare system applied in Russia.
THE GENDER-SPECIFIC FEATURES OF REHABILITATION OF THE PATIENTS PRESENTING WITH PAIN IN THE SPINE OF VERTEBROGENIC GENESIS
Authors: Bulakh O. A , Filatova Elena V. , Polkovnikova E. V , Privalova N. M
Published: September 2020

Comparative analysis of the effectiveness of different methods of physical therapy including hydrokinesitherapy and therapeutic gymnastics with the use of exercises on an unstable support (stabiloplatform) was made for a group of 72 patients suffering from pain in the spine of vertebrogenic genesis who had repeatedly received standard medical therapy, physiotherapy (magnetotherapy, laser therapy), and massage therapy before the onset of the study. The effectiveness of therapy was assessed based on the VAS scale, using the Schober’s test, Tomaier test, and Ott test as well as the summary index of health status. The pain intensity estimated based on the VAS scale was significantly reduced in all the patients after the completion of the treatment. Especially good results were obtained for the group of men making exercises on the stabiloplatform and in the group of women given hydrokinesitherapy in the water pool. The results of the present study of the psychoemotional state, vertebroneurological status, and spinal pain intensity in the patients presenting with dorsopathies lead to the conclusion that men and women respond differently to the rehabilitative treatment with the use of the static and dynamic methods of physical therapy.
SYSTEMIC THERAPY AND PHOTOTHERAPY OF PSORIASIS - THE POTENTIAL RISKS OF CANCER
Authors: Kulbiy D. S , Ponich E. S , Kruglova Larisa Sergeevna
Published: September 2020

The relevance of studying psoriasis and its treatment is conditioned by the ever increasing incidence of this condition and frequency of its severe forms. The recent studies on the complications of both psoriasis itself and its treatment have demonstrated the increased risk of associated carcinogenesis. The analysis and systematization of information accumulated to date gives evidence of the relationship between the development of cancer and the application of modern methods for the treatment of psoriasis Moreover, the available data suggest the enhanced risk of cancer in the patients suffering from this disease compared with that in the general population.
ROLE OF PHYSICAL LOADS AND DRINKING MINERAL WATER IN PREVENTION AND TREATMENT OF OBESITY - BASIS OF METABOLIC SYNDROME
Authors: Barieva Yu. B , Botvineva L. A , Kaysinova Agnessa Sardoevna , Samsonova N. A
Published: September 2020

The review is devoted to the topical issues of non-pharmacological treatment of metabolic syndrome, namely, fight against hypodynamia (the mechanism of sanogenetic action of Scandinavian walking) and insulin resistance (the effect of drinking mineral water on normalization of insulin secretion). Non-medicamentous measures aimed at reducing body weight, changing dietary stereotypes, quiting bad habits such as smoking and alcohol abuse, increasing physical activity. These changes contribute to the formation of healthy lifestyle, they are highly effective, increase oxygenation of tissues, improve functional state of the cardiovascular and respiratory systems and have a pathogenetically directed effect on all links of metabolic syndrome: abdominal obesity, dyslipidemia, violation of carbohydrate metabolism, hyperinsulinemia, insulin resistance, sympaticotonia, arterial hypertension.
COMPLEX APPLICATION OF POLYCHROMATIC INCOHERENT RADIATION AND SURFACE ENZYME-ACTIVE PUMP TISSUE PAM-T IN THE PURULENT PROCESSES OF THE MAXILLOFACIAL REGION
Authors: Ivanova Irina Ivanovna , Rodionov A. D
Published: September 2020

The results of complex application of polychromatic incoherent radiation and surface enzyme-active pump tissue PAM-T in purulent processes of the maxillofacial region are reflected. Studies were carried out on 120 patients with suppurative processes of the maxillofacial region. The authors proved that the complex of polychromatic incoherent radiation and PAM-T in purulent processes of the maxillofacial region has a pronounced anti-inflammatory, analgesic and anti-edematous effects, more pronounced compared with the use of polychromatic incoherent radiation and especially standard treatment, which is confirmed by the coping of all the main complaints and objective signs of the disease and the data of the clinic boron research.
EFFECTIVENESS OF VISUAL COLOR IMPULSE THERAPY IN REHABILITATION OF PATIENTS WITH CARDIOVASCULAR DISEASES WITH ASTENO-DEPRESSIVE SYNDROME
Authors: Lazarenko Nina Nikolaevna , Sekirin A. B , Prikuls V. F , Smirnova S. N , Supova M. V , Trunova O. V , Ostrovskiy E. I , Gerasimenko M. Yu , Soldatov A. A
Published: September 2020

It is known that neurotic disorders can be independent risk factors for the development of complications in patients with cardiovascular diseases. This requires the creation of new rehabilitation programs that include not only medicines but also physiotherapy. To this end, an analysis was made of the effect of complex treatment, including visual color impulse therapy, on the psychoemotional state of 80 patients with cardiovascular diseases, hypertensive disease and coronary heart disease, who also have asthenic-depressive symptoms. In this case, patients in two control groups received standard drug therapy, and in the two main groups received additional color pulse therapy from the «Mellon» apparatus. Dynamics of the psychoemotional state of patients was studied with the help of a test that determines the quantitative changes in the state of health, activity and mood, as well as the stress index that characterizes the regulation of the heart rhythm under stress. Prior to the start of treatment, functional disintegration of regulatory mechanisms was characteristic for all patients, which was accompanied by psychoemotional disorders that indirectly reflected the state of highly organized nervous processes in the cerebral cortex, which altered the values of SI stress index indicators and the «well-being, activity, mood» test. The regression statistical analysis was used in this work. As a result, the indications and contraindications to the use of this method of treatment were determined. After the course of complex treatment, including drug and visual color impulse therapy, positive dynamics in the patients’ state was revealed, which indicates an increase in the functional capabilities of their body, and also, given the good tolerability of visual color impulse therapy, the feasibility of including this method in complex treatment at any stage of rehabilitation.
PSYCHOCORRECTING EFFECT OF TRANSCRANIAL MAGNETIC EXPOSURES WITH SYNCHRONIZED OPHTALMOCHROMOTERAPY FOR PERIPHERAL DISTRIBUTIONS OF RIDGE AT THE SPORTSMEN OF FIGHTING SPORTS
Authors: Korchazhkina Natalia Borisovna , Katsnelson V. V , Drakon A. K
Published: September 2020

The results of application of transcranial magnetic influences and synchronized ophthalmic chromotherapy in the complex program of restorative treatment of 120 sportsmen of fighting sports with peripheral dystrophies of the retina are reflected in the article. The authors proved that the combined use of transcranial magnetic effects and synchronized ophthalmic chromotherapy lead to a greater extent than transcerebral low-frequency magnetotherapy as a monomethod, causes a pronounced psychocorrecting effect, which manifests itself in increasing emotional stability and resistance to stress and reducing anxiety (according to color Lusher’s test), as well as in improving the state of health of activity and mood (according to the SAN test).
FUNCTIONAL AND MOLECULAR-GENETIC REACTIONS UNDER CONDITIONS OF CONDUCTING HEALTH PROGRAMS IN PERSONS WITH EXCESSIVE BODY MASS
Authors: Lysenkov Sergey Petrovich , Korchazhkina N. B , Tkhakushinov R. A , Tuguz A. R
Published: September 2020

In a study of 116 healthy and obese patients (20-63 years), authors have made an assessment of the functional and molecular genetic effects of the health program, which included caloric restriction of food up to 1,000-1,200 calories per day, or a complete rejection of food within 19-21 days, intestinal cleansing, physical exercising in the way of walking 3-7 kilometers per day, laser therapy, body massage, infrared sauna, etc., educational lectures, sessions of spiritual music. The healthy course had been accompanied by loss of total and fat mass, normalization of hemodynamic parameters, cholesterol, leptin, insulin and glucose levels, decrease in insulin- and leptin-resistance. Molecular genetic studies have shown that genotype T23525T of FTO gene is the most unfavorable genotype for residents of the North Caucasus, increasing the risk of developing obesity 2.33-4.90 times. This genotype reliably correlated with the body mass index, weight, the initial fat mass, and the hip circumference. However, the presence of this genotype did not prevent the loss of body weight and fat during the process of health improvement measures. In addition, the phenomenon of transversion of nucleotides (A → T) was detected at the corresponding site of 23525 intron mutations (rs9939609). The established effect shows the possibility of targeted effects on the human genome through health programs. The mechanisms of transversion require explanations and further studies.
To choose the use of 2d or 3d images in rehabilitation: review
Authors: Kubryak O. V. , Kriklenko Elena Aleksandrovna
Published: September 2020

Different properties of displays, features of visual perception of three-dimensional images and other conditions, probably affect the effectiveness of motor rehabilitation when using a visual feedback channel and virtual reality technology. A brief review presents the latest publications on a choice of 2D or 3D displays. It is concluded that the presence of many features not only creates difficulties in comparing the effects of using various equipment, but also provides the potential for targeted display selection for a particular rehabilitation task.
The application experience of terahertz radiation for osteoarthritis of the knee
Authors: Kulikov A. G. , Ageeva Anna Ivanovna , Volovets S. A.
Published: September 2020

The aim of this work was to increase the effectiveness of treatment in patients with osteoarthritis of the knee by including in the treatment complex procedures of electromagnetic radiation of the terahertz range. This study was prospective and randomized. 65 patients were examined and treated. They were divided into 2 groups comparable to sex, age, disease type, and severity. All patients received basic therapy, including drugs and exercise therapy. In addition to the basic treatment, the patients of the main group underwent a course of terahertz therapy using the Emir device with a ceramic coating of the emitter. The study revealed that the procedures of terahertz therapy are well tolerated by patients, do not cause exacerbation and are combined with other methods of treatment of gonarthrosis. Repeated studies at the end of the course of treatment showed that the inclusion of terahertz radiation in the therapeutic complex has a positive effect on the main clinical symptoms of the disease, reducing the intensity of pain in the knee joints and improving their functional state, having a favorable effect on the state of local hemodynamics.
Therapeutic and rehabilitation complex for the treatment of patients with chronic generalized periodontitis and bruxism
Authors: Khaybullina Rasima R. , Gerasimova Larisa P. , Gilmutdinova Lira T. , Gerasimenko Marina Yu.
Published: September 2020

Background. The article discusses modern concepts of the relationship of periodontal disease and bruxism.
Aim: to study the efficiency of the proposed therapeutic and rehabilitation complex for patients with chronic generalized periodontitis and bruxism.
Methods. 73 patients aged 3045 years with a diagnosis of chronic generalized periodontitis of moderate severity and bruxism were examined. The control group consisted of 15 apparently healthy individuals of the same age to clarify the functional parameters of the norm. To assess the effectiveness of the proposed therapeutic and rehabilitation complex, clinical, Doppler flowmetric and electromyographic research methods were used.
Results. High efficiency of the therapeutic and rehabilitation complex in the treatment of chronic generalized moderate periodontitis and bruxism has been revealed. An analysis of changes in time of clinical symptoms revealed that when using this program, which includes basic therapy, laser phoresis, ozone irrigation of the gums, the intake of phyto-complex and local-mineral complexes, the use of dental pins with propolis and phytocomplex, physiotherapy exercises and fluctuorization, positive changes were pronounced. Under the influence of the course effect of therapeutic procedures, patients showed an increase in blood perfusion volume by 37.7% (p 0.05), blood flow perfusion rate by 58.2% (p 0.05) from the initial values. At the same time, a decrease by 51.82% (p 0.05) from the initial indices of bioelectric activity of the temporal muscle at rest was registered, as well as by 40.4% (p 0.05) with voluntary constriction, and a decrease in the bioelectric activity of the mastication muscle at rest by 47.4% (p 0.05), and with voluntary constriction by 35.12% (p 0.05).
Conclusion. The data obtained based on electromyography and laser Doppler flowmetry indicate that the developed treatment and rehabilitation complex is an effective method for correcting the microcirculation of periodontal vessels, the functional activity of the maxillofacial muscles.
THE SATISFACTION WITH MEDICAL SERVICES AS AN INDICATOR OF EFFICIENCY OF FUNCTIONING OF MEDICAL INSTITUTION
Authors: Shishkina E. A , Kuandykov G. B
Published: September 2020

The need in optimization of strategies of activities of various health care structures focuses scientific practical interest to studying a degree of satisfaction of patients with not only received medical care but psychological interactions with specialists, sanitary hygienic, organizational, sociocultural and other characteristics of curative institution. The purpose of study is targeted to corroborate a hypothesis about expediency of involvement of sociological surveys to medical care quality assessment in conditions of practical health care institutions. The article designates theoretical foundation of the problem and expounds results of applied study (questionnaire survey) targeted to evaluate competence and level of professionalism of specialists, benevolence of employees, diagnostic possibilities, sanitary hygienic conditions and also preventive, informational and organizational functioning of institution. On the basis of gender and age-related criteria differences in indices of requirements of respondents were established and their common needs in sphere of supporting physical and social health as well.
THE QUALITY OF MEDICAL CARE IN MEDICAL ORGANIZATIONS OF MOSCOW PUBLIC HEALTH CARE SYSTEM IN APPRAISALS OF PATIENTS AND PHYSICIANS
Authors: Tadjiev I. Ya , Belostotsky A. V , Budarin S. S
Published: September 2020

The article presents the analysis of results of complex medical sociological survey of effectiveness and efficiency of medical care as main criteria of its quality and accessibility. The survey comprised 1,737 patients of various social groups of population of Moscow and 203 physicians of polyclinics. At self-rating of health, 13.2% of respondents determined it as unsatisfactory, 45.1% as satisfactory and 31.3% as good. In all population groups, the most called-for proved to be polyclinic institutions. The high level of satisfaction of patients with quality of emergency medical care was established in all groups. The quality of medical care in polyclinics and hospitals was assessed significantly lower. The most negatively assessed criteria turned out transition to fee-for-service forms of medical support and time limits of waiting for all modes of medical care, except emergency medical care and district therapist. The evaluation by physicians of their own activity and present problems is characterized by their unanimity in need of increasing of salary (100%) and increasing of typical sectoral standards of time of reception of a patient (96.5%), decreasing of intensity of work of medical personal (92.3%) and reduction of some forms of record cards with the purpose of releasing of time and attention of physician for a patient (88.4%). The disrespectful attitude of patients to medical personnel was mentioned by 77.3% of physicians which is a new phenomenon testifying loss of confidence in patient-physician relationship. The quality of implemented work was assessed equally and rather high by both young and experienced physicians. The positive and negative aspects of reorganization of health care were analyzed. Two alternatives of problems were established to focus plans of development of system of Moscow health care to support accessible and qualitative medical care of population.
THE RESEARCH COMPETENCE OF PRACTICAL PHYSICIAN AS A FACTOR OF IMPROVEMENT OF PROFESSIONAL SELF-REALIZATION
Authors: Krasovsky V. S
Published: September 2020

The article presents the analysis of impact of research competence on the process of professional self-realization of practical physicians. The personal self-perception of physician from positioning of oneself as active subject of cognition, opened to new experience and ready for getting out of available scope of knowledge is considered as an indicator of availability and developness of research competence at the stage of post-graduate stage of profession genesis. The article presents a complex of qualities of subject needed to successful self-realization in profession in conditions of modern medicine. The questionnaire survey was applied to assess through physicians the process of receiving and application of experience of research activities in university and also of the course of professional self-realization. The questionnaire emphasized such research skills as scientific informational, methodological, theoretical, empirical, written speech and communicative speech ones. The testing was applied to compare self-rating of physicians in the area of research skills and real research knowledge and skills. The results testify an inadequate attention to development of research competence at pre- and post-graduation work stages of professional genesis. The cohort of young specialists is considered as a most perspective one for working in this direction in state structures.