bluuebunny/crossref_metadata_2025 huggingface dataset:
An analysis of the services provided by Community Health Workers within an urban district in South Africa: a key contribution towards universal access to care.
Authors: Thomas Leena Susan , Buch Eric , Pillay Yogan
Published: February 2021

Introduction: Community health worker teams are potential game-changers in ensuring access to care in vulnerable communities. Who are they? What do they actually do? Can they help South Africa realize universal health coverage? As the proactive arm of the health services, community health workers teams provide household and community education, early screening, tracing and referrals for a range of health and social services. There is little local or global evidence on the household services provided by such teams, beyond specific disease-oriented activities such as for HIV and TB. This paper seeks to address this gap.Methods: Descriptive secondary data analysis of community health worker team activities in the Ekurhuleni health district, South Africa covering approximately 280 000 households with one million people. Results: Study findings illustrated that community health workers in these teams provided early screening and referrals for pregnant women and children under five. They distributed condoms and chronic medication to homes. They screened and referred for hypertension, diabetes mellitus, HIV and TB. The teams also undertook defaulter and contact tracing, the majority of which was for HIV & TB clients. Psychosocial support provided was in the form of access to social grants, access to child and gender-based violence protection services, food parcels and other services.Conclusion: Community Health Workers form the core of these teams and perform several health and psychosocial services in households and poor communities in South Africa, in addition to general health education. The teams studied provided a range of activities across many health conditions (mother & child related, HIV & TB, non-communicable diseases), as well as social services. These teams provided comprehensive care in a large-scale urban setting and can improve access to care.
Predicting Future Mutations To Inform Vaccine Design
Authors: Chattopadhyay Ishanu , Li Jin , Li Timmy , Esser-Kahn Aaron
Published: February 2021

Influenza viruses constantly evolve, and mismatches between predicted and circulating strains impact vaccine effectiveness. A barrier to predicting the season-specific dominant strains is the limited ability to predict future mutations, or estimate the numerical likelihood of specific future strains. Here, we introduce a biology-aware sequence similarity metric based on deep pattern recognition of evolutionary constraints, that calculate the odds of future mutations, outperforming WHO recommended flu vaccine compositions almost consistently over the two decades.
Bacteriophage cocktail supplementation improves growth performance, gut microbiome and production traits in broiler chickens
Authors: Upadhaya Santi Devi , Ahn Je Min , Cho Jae Hyoung , Kim Jin Young , Kang Dae Kyung , Kim Sung Woo , Kim Hyeun Bum , Kim Inho
Published: February 2021

Background: Effective antibiotic alternatives are urgently needed in the poultry industry to control disease outbreaks. Phage therapy mainly utilizes lytic phages to kill their respective bacterial hosts and can be an attractive solution to combating the emergence of antibiotic resistance in livestock. Methods: Five hundred and four, one-day-old broilers (Ross 308) were allotted to 1 of 4 treatment groups in a completely randomized design. Treatments consisted of CON (basal diet), PC (CON + 0.025% Avilamax®), BP 0.05 (CON + 0.05% bacteriophage), and BP 0.10 (CON + 0.10 % bacteriophage). Results: A significant linear effect on body weight gain (BWG) was observed during day 1-7, day 22-35, and cumulatively in bacteriophage (BP) supplemented groups. The BWG tended to be higher (P = 0.08) and the feed intake (FI) was increased (P = 0.017) in the PC group over CON group. A greater (P = 0.016) BWG and trends in increased FI (P = 0.06) were observed in the experiment in birds fed PC than CON diet. At the genus level, the relative abundance of Lactobacillus was decreased in PC (65.28%), while it was similar in BP 0.05 and BP 0.10 (90.65%, 86.72%) compared to CON (90.19%). At the species level, the relative abundance of Lactobacillus salivarus was higher in BP 0.05 (40.15%) and BP 0.10 (38.58%) compared to the CON (20.04%) and PC (18.05%). A linear reduction in the weight of Bursa of Fabricus (P = 0.022) and spleen (P = 0.052) was observed in birds fed graded level of BP and an increase (P = 0.059) in the weight of gizzard was observed in birds fed PC over BP diets. Linear and quadratic responses were observed in redness of breast muscle color in birds fed graded level of BP. Conclusions:The inclusion of the 0.05% and 0.1% BP cocktail linearly improved broiler weight during the first 7 days, 22-35 days and cumulatively, whereas 0.05% BP addition was sufficient for supporting immune organs, bursa and spleen as well as enhancing gut microbiome, indicating the efficacy of 0.05% BP as a substitute antibiotic growth promoter in broiler diets.
Neuropsychiatric, cognitive and sexual impairment in mastocytosis patients
Authors: Jendoubi Fatma , Severino-Freire Maella , Negretto Mathilde , Arbus Christophe , Paul Carle , Livideanu Cristina Bulai
Published: February 2021

Background: Mastocytosis is a rare disease characterised by the accumulation and/or proliferation of abnormal mast cells (MCs) in one or several organs. It may present with a number of different symptoms that involve various organ systems. The current study aims to assess the prevalence of MC mediator-related symptoms in a cohort of mastocytosis patients with a specific focus on neurological, psychiatric, cognitive and sexual symptoms. We also assessed the impact of the disease on patients’ professional lives.Patients were administered a validated multidimensional questionnaire to collect information on patients’ perception of the severity of their symptoms. From the questionnaires we extracted the neurological, cognitive, psychiatric and sexual symptoms and the impact of the disease on patients’ professional lives as well as their grading. The affective status was assessed using the 17-item version of the Hamilton Depression Rating Scale. Results: We included 139 patients. Mastocytosis was classified as systemic in 113 patients and cutaneous in 26 patients. The prevalence of MC mediator-related systemic symptoms was as follows: cutaneous (71%), gastro-intestinal (48%), cardio-vascular (36%), musculoskeletal (26.6%), fatigue (24%), urinary (14.4%) and respiratory (10%). Headaches and vertigo were noted in respectively 55% and 32% of patients. Irritability, episodes of memory loss and difficulty concentrating were reported in 54%, 52% and 40% of cases, respectively. Sexual impairment was noted in 24% of patients. No associations were found between neuropsychiatric/cognitive impairment and age, gender, diagnostic delay, disease form, the presence of cutaneous lesions, the level of serum and bone marrow tryptase and the presence of KIT mutation in bone marrow and/or skin. Depression was noted in 49% of patients. One in four patients reported a negative impact of the disease on their professional lives.Conclusions: This current study provides some insights regarding symptoms related to mastocytosis and their impact on patients’ professional lives.
Optimization of iron removal in water by nanobubbles using response surface methodology
Authors: Sun Cuizhen , Wang Guoxiu , Sun Caijuan , Liu Rupeng , Zhang Zhibin , Marhaba Taha , Zhang Wen
Published: February 2021

Iron contamination, causing staining, discoloration and bad taste, is a worldwide water problem. It is necessary to focus on iron oxidation from the water. This work aims to develop nanobubbles (NBs) technology to remove iron (Fe2+) from aqueous solutions. In batch experiments, the effects of initial Fe2+ concentration, pH, and aeration pressure on the Fe2+ oxidation efficiency were carried out. The results showed that initial concentrations, pH and aeration pressure are significant parameters influencing Fe2+ oxidation. On the basis of single factor experiments, the Box–Behnken design was used to optimize the Fe2+ oxidation conditions with NBs using three parameters (Fe2+ concentration, pH, and aeration pressure) under the response surface methodology. The optimal Fe2+ oxidation was achieved when the initial concentration was 13.7 mg·L−1, pH = 9, and the aeration pressure was 290 kPa. The regression model of Fe2+ oxidation rate under optimized test conditions is accurate and effective. The results showed that the combination of single factor test and response surface optimization can be used to optimize the Fe2+ oxidation process with NBs. It is concluded that NBs technology is promising for Fe2+ oxidation from water.
Reposition of the Fungicide Ciclopirox for Cancer Treatment
Authors: Huang Zhu , Huang Shile
Published: February 2021

Background:

Ciclopirox (CPX), a broad-spectrum fungicide, has been widely used to
treat fungal infection on the skin and nails for decades. Recent preclinical and clinical studies have
shown that CPX also possesses promising anticancer activity.

Objective:

The objective of this study is to summarize the patents, the pharmacological and toxicological
properties, the anticancer activity, and the mechanisms of action of CPX and its derivatives
as anticancer agents.

Methods:

PubMed and Google using the keywords “ciclopirox”, “cancer or tumor” and “patent”
were searched, and the identified literature was reviewed.

Results:

Pharmacological and toxicological profiles from preclinical and clinical studies support
that systemic administration of CPX and its derivatives is feasible and safe for cancer treatment.
CPX exerts its anticancer activity by inhibiting cell proliferation, inducing apoptosis, suppressing
cell migration and invasion, and inhibiting angiogenesis and lymphangiogenesis. Mechanistically,
CPX impacts the expression or activities of multiple signaling molecules or pathways, such as ribonucleotide
reductase, Myc, DJ-1, Wnt/β-catenin, DOHH/eIF5A/PEAK1, VEGFR-3/ERK1/2,
ATR/Chk1/Cdc25A, and AMPK/TSC/mTORC1. Most of these effects are attributed to iron chelation
by CPX. Five patents have been retrieved: four patents on the development of CPX prodrugs
to improve the water solubility and bioavailability of CPX, and one patent on the methods of bladder
cancer treatment with CPX, CPX-O, or a CPX prodrug.

Conclusion:

CPX has a great potential to be repositioned for cancer therapy.
Withdrawal Notice: Role of Zinc Oxide Nanoparticles Synthesized by Fenugreek Seeds Extract as Anticancer Agent: In Vitro and In Vivo Studies
Authors: Radwan Aliaa M. , Aboelfetoh Eman F. , Kimura Tetsunari , Mohamed Tarek M. , El-Keiy Mai M.
Published: February 2021

The article has been withdrawn on the recommendation of the Editor-in-Chief of the journal Anti-Cancer Agents in Medicinal Chemistry; due to some inconsistencies in the content of the article.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

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The Beneficial Effect of Rice Bran Extract Against Rotenone-Induced Experimental Parkinson’s Disease in Rats
Authors: Kumar Sachin , Kumar Puneet
Published: February 2021

Background:

Neurodegenerative diseases have become an increasing cause of various disabilities worldwide, followed by aging, including Parkinson’s disease (PD). Parkinson’s disease is a degenerative brain disorder distinguished by growing motor & non-motor failure due to the degeneration of medium-sized spiked neurons in the striatum region. Rotenone is often employed to originate the animal model of PD. It is a powerful blocker of mitochondrial complex-I, mitochondrial electron transport chain that reliably produces Parkinsonism-like symptoms in rats. Rice bran (RB) is very rich in polyunsaturated fatty acids (PUFA) and nutritionally beneficial compounds, such as γ-oryzanol, tocopherols, and tocotrienols and sterols are believed to have favorable outcomes on oxidative stress & mitochondrial function.

Objective:

The present study has been designed to explore RB extract’s effect against rotenone-induced neurotoxicity in rats.

Methods:

In the present study, Rotenone (2 mg/kg, s.c) was administered systemically for 28 days. The hexane extract of RB was prepared using Soxhlation. Hexane extract (250 & 500 mg/kg) was administered per oral for 28 days in rotenone-treated groups. Behavioral parameters (grip strength, motor coordination, locomotion, and catalepsy) were conducted on the 7th, 14th, 21st, and 28th day. Animals were sacrificed on the 29th day for biochemical estimation in the striatum and cortex.

Result:

This study demonstrates significant alteration in behavioral parameters, oxidative burden (increased lipid peroxidation, nitrite concentration, and decreased glutathione, catalase, SOD) in rotenone-treated animals. Administration of hexane extract of RB prevented the behavioral, biochemical alterations induced by rotenone. The current research has been sketched to inspect RB extract’s effect against rotenone-developed neurotoxicity in rats.

Conclusion:

The findings support that PD is associated with impairments in motor activity. The results also suggest that the nutraceutical rice bran that contains γ-oryzanol, Vitamin-E, ferulic acid etc., may underlie the adjuvant susceptibility towards rotenone-induced PD in experimental rats.
Evaluation of Microbial Profile of Milk and Some Dairy Products in Ilam, West of Iran
Authors: Bastam Mahsa Morovati , Jalili Mahsa , Sadeghifard Nourkhoda , Pakzad Iraj , Taherikalani Morovat , Ghafourian Sobhan
Published: February 2021

Background:

Food-borne diseases can cause many problems and harm consumers and societies. Dairy products are an important part of the food pyramid. In addition, dairy products provide many nutritional needs to humans and can also be contaminated with bacteria and cause gastrointestinal diseases and food poisoning.

Objective:

The purpose of the present research was to evaluate bacterial contamination rate in cheese, raw and pasteurized milk.

Methods:

For this purpose, 100 samples, including 35 samples of raw milk samples, 35 samples of pasteurized milk and 30samples of cheese, were evaluated. Cultures, biochemical and phenotypic tests were performed. Finally, statistical analysis was performed.

Results:

Our finding demonstrates that Enterococcus spp was the highest rate in cheese samples, E.coli was the highest rate in raw milk samples, and citrobacter freundii, klebsiella oxytoca and enterococcus spp were of the same rate in pasteurized milk samples.

Conclusion:

The results obtained in this study demonstrated that some dairy products in Ilam province, were contaminated. So, we suggested that the pasteurized milk and dairy products be done with complete care and raw dairy products should not be used.
In-silico Design of Multi-epitope Vaccine against Nipah Virus using Immunoinformatics Approach
Authors: Raju Suraj , Sahoo Debasish , Bhari Vikas Kumar
Published: February 2021

Nipah virus is a pleomorphic virus that causes high mortality with unpredictable outbreaks. The virus also shows high zoonotic potential with long term neurological damage after recovery further adding to the disease burden. An in-silico epitope-based vaccine offers a promising solution to supplement wider efforts to control the viral spread. This is achieved through immunoinformatics approach using a plethora of servers available. We derived cytotoxic T-cell, T-Helper, B-cell and IFN-γ targeting epitopes from surface glycoprotein G. Cytotoxic T-cell specific epitopes, HLA-B*4402, chimeric multiepitope vaccine structures were prepared using homology modelling method. The structures were validated using various methods and docking simulation was performed between epitopes and HLA-B*4402. Similarly, the vaccine construct was docked to Toll like receptor-4 and a molecular dynamics simulation was performed to assess stability of interaction. Both the docking simulations showed stable interactions with their respective receptors. Immune-simulation was carried out to validate the efficacy of vaccine candidate which showed elevated levels of antibodies such as IgM and IgG due to increase in active B cell population. Both in-vitro and in-vivo serological analysis is required for confirmation of vaccine potency. To facilitate this effort, codon optimization was undertaken to remove existing codon bias. The optimized gene sequence was cloned into the PUC19 vector to express in Escherichia coli K12 strain. Additionally, a poly histidine (6xHis) tag was added at the C-terminal end to ease the purification step. The immune-informatics approach hopes to accelerate vaccine development process to reduce the risk of attenuation while increasing the success rates of pre-clinical trials.
El papel de la comunicación de la ciencia en la pandemia actual
Authors: Sánchez Mora María del Carmen , Crúz-Mena Javier , Sánchez Mora Ana María
Published: February 2021

Ante la pandemia actual, y en vista de la ola de desinformación, de información incierta, incorrecta o alterada, es conveniente discutir si la comunicación de la ciencia, cuyos objetivos son en principio diferentes a los de una campaña, pudiera intervenir para contrarrestar en alguna medida esta problemática.
Structure and microhardness of binding for diamond tools based on tungsten carbide obtained by impregnation of iron-carbon melt
Authors: Sharin P. P. , Akimova M. P. , Yakovleva S. P. , Popov V. I.
Published: February 2021

In this work, an experimental modeling of the technology for producing a matrix by sintering a diamond-containing briquette with a filler of tungsten monocarbide powder impregnated with a Fe-C eutectic melt in a vacuum is carried out. The microstructure, elemental and phase compositions of the products formed in the process of sintering a diamond-containing matrix with impregnation with a Fe-C eutectic melt in vacuum have been studied by scanning electron microscopy, X-ray spectral and X-ray phase analyzes, and Raman spectroscopy. It was found that the matrix consists of 61.0% tungsten carbide phases, 17.0% of iron carbide, 16.5% of α-Fe, and 5.5% of graphite. The eutectic Fe-C alloy, which serves as a matrix binder, consists of a ferrite-pearlite metal base with graphite inclusions. It is shown that at the diamond - matrix interface, graphite inclusions are formed not as a continuous layer, but as discontinuous areas along the perimeter of diamond grains. The microhardness of the WC-based matrix impregnated with the Fe-C melt is ~ 11 GPa, which is more than 3 times higher than the microhardness of the WC-Co-Cu hard alloy matrix obtained by sintering with copper impregnation.The research results can be used in the development of technology for the manufacture of wear-resistant matrices of diamond tools of a wide class used in the processing of materials with a high level of hardness.
Nutritional Profiling and Heavy Metal Analysis of Withania Somnifera Based Polyherbal Formulation- Aswagandhadi Lehyam
Authors: Ben Raj  , S.R Madhan Shankar
Published: February 2021

Aswagandhadi lehyam, is one of the most popular formulations prescribed as Rasayana (tonic) in the traditional medical system of India, Ayurveda.  As like other lehyam  formulations,  Aswagandhadi  lehyam  prepared  as per the avaleha Kalpana in ayurveda. The formulation received its name from its major ingredient, Ashwagandha (Withania somnifera). Even though the Aswagandhadi lehyam used generally as rasayana, its major ingredient Ashwagandha has various medical benefits. Ashwagandha  is  compared  well  with  Eleutherococcus  senticosus  (Siberian  Ginseng)  and  Panax  Ginseng  (Chinese  /  Korean Ginseng) in its adaptogenic  properties,  and hence it is popularly known as Indian  Ginseng. Since it is used as majorly as rasayana,  in  addition  to its  pharmacological  studies  and chemical  standardisation  its  nutritional  profiling  also  needs  to be studied. In the present study the nutritional profiling of the Aswagandhadi lehyam is studied, which will provide a better idea regarding  the nutritional  values while consumed generally  for increasing physical strength, endurance,  stamina, vitality and vigor. It is also important to have an understanding regarding the heavy metal contamination of the formulation. Heavy metal analysis  of  the  formulation  is  done  in  Inductively  coupled  plasma  mass  spectrometry  (ICP-MS).  The  aswagandhadi  lehyam prepared as per avaleha kalpana and Sahasrayogam, is regarded as the industrial working standard, and is considered for the study.. The organoleptic analysis reported - as smooth, dark brown sweet product, pleasant aroma and creamy texture. Nutritional profiling results evidenced the health benefits of the formulation including ~389 kCal of energy value, 2.1% fibre content etc. Heavy metal contamination study done with ICPMS reported the presence of trace elements like Mercury (Hg), Arsenic (As), Lead (Pb), and Cadmium (Cd) in a range of 0.02-0.39 ppm.
PEMBERDAYAAN PEREMPUAN MELALUI PELATIHAN PEMANFAATAN KAIN PERCA SEBAGAI AKSESORIS MELALUI MEDIA YOUTUBE DI BENING SAGULING
Authors: Zakiya Tsaniatu
Published: February 2021

The Bening Saguling is located on Jl. Babakan Cianjur, Kec. Cihampelas, Kab. West Bandung. Most of the people are housewives who do not work, with varying degrees of education, but most of them are junior and senior high school graduates. This is due to limited funds to continue to higher school levels, besides that there are other factors, namely the social structure factor that urges women to marry immediately at a young age which provides a great opportunity for women to become unproductive and only fully depend on their husbands who work as laborers. in a big city. The Bening Saguling NGO is a forum for the surrounding community to get training so that the community is able to improve the quality of life at large while still adhering to environmental preservation. The purpose of this research is to describe in more detail about women's empowerment through training on the use of patchwork as accessories through Youtube media in Bening Saguling. This study uses a descriptive method with a qualitative approach, which is the subject of this study, namely one training manager and 10 housewives. While the data collection technique is by means of observation, interview and documentation. The result of this training is to provide patchwork skills for low-educated women, providing a skill that can be of personal use and of sale value. The benefits of this activity are that the work can be sold so that it is expected to be able to improve the standard of living of the community and fill women's spare time with more useful activities.
IMPLIKASI PELATIHAN MASSAGE TERHADAP KETERAMPILAN HIDUP TUNANETRA DI MASA PANDEMI COVID-19
Authors: Mulyani Sri
Published: February 2021

Penelitian ini dilatar belakangi oleh keterbatasan penglihatan, tunanetra tidak segan untuk memiliki keterampilan massage. Penelitian ini bertujuan agar stigma yang ada di masyarakat, bahwa tunanetra hanya bisa mengemis dan mengamen dapat dirubah dengan adanya pelatihan massage yang memberikan keterampilan hidup untuk dijadikan mata pencaharian. Metode yang digunakan adalah pendekatan kualitatif dengan menggunakan metode deskriptif melalui teknik wawancara. Hasil dari penelitian ini menunjukkan bahwa pelatihan massage sebagai salah satu alternative dalam membentuk karakter tunanetra menjadi mandiri dan terampil. Pembahasan mengemukakan pelatihan massage yang mana pelaksanaanya terhambat oleh pandemic covid-19, akan tetapi tidak menyurutkan balai untuk menghentikan semua kegiatan pelatihan, tetap berupaya dengan berbagai media untuk menyampaikan materi serta praktek. Walaupun peserta kesulitan dalam proses pelatihan tidak mematahkan semangatnya untuk memiliki keterampilan hidup. Kesimpulan dari penelitian ini yaitu keterampilan hidup merupakan hal yang penting bagi setiap manusia tidak terkecuali usia maupun jabatan, pelatihan massage menjadi salah satu bukti bahwa dengan adanya balai memberikan pelatihan mampu memberikan dampak positif terhadap para tunanetra.
A study of cointegration of gold market of the emerging and developed economies
Authors: Sidana Ajay , Sidana Neeru , Sood Rohit
Published: February 2021

Gold, which is considered to be the most precious metal (Bilal, Talib, Haq, Khan, & Naveed, 2013), from ancient times has been considered as a very conservative investment. Studies examining the utility of gold have found evidence in favour of gold as a source of the hedge (Narayan, Narayan, & Zheng, 2010; Bampinas & Panagiotidis, 2015), diversification (Ibrahim, 2012; Hoang, Lean, & Wong, 2015), as well as a safe haven in times of adverse market movements (Ciner, Gurdgiev, & Lucey, 2013; Bredin, Conlon, & Potì, 2015). This paper attempts to study how global gold price trends impact domestic gold prices and domestic gold price trends contemplate in international gold markets. The study has been based on 3157 observations of daily data recorded over a period of 13 years – from March 2005 to December 2018 – to show the relationship between the USA and India’s gold market. This paper fills the need for empirical evidence for the short and long-term interrelation between India and USA gold markets and the results show no evidence of a long-term association between Indian and COMEX gold spot prices.
Harvesting can stabilize population fluctuations and buffer the impacts of climate change
Authors: Peeters Bart , GrØtan Vidar , Gamelon Marlène , Veiberg Vebjørn , Lee Aline Magdalena , Fryxell John , Albon Steve , Sæther Bernt-Erik , Engen Steinar , Loe Leif , Hansen Brage
Published: February 2021

Harvesting can magnify the destabilizing effects of environmental
perturbations on population dynamics and, thereby, increase extinction
risk. However, population-dynamic theory predicts that impacts of
harvesting depend on the type and strength of density-dependent
regulation. Here, we used population models for a range of life
histories and an empirical reindeer case study to show that harvesting
can actually buffer populations against environmental perturbations.
This occurs because of density-dependent environmental stochasticity,
where negative environmental impacts on vital rates are amplified at
high population density due to intra-specific resource competition.
Simulations from our population models show that even low levels of
proportional harvesting may prevent overabundance, thereby dampening
population fluctuations and reducing the risk of population collapse and
quasi-extinction induced by environmental perturbations. Thus, depending
on the species’ life history and the strength of density-dependent
environmental drivers, harvesting can improve population resistance to
increased climate variability and extreme weather expected under global
warming.
What can we learn from outliers in Cardiac Surgery?
Authors: Salmasi Mohammad , Jarral Omar , Athanasiou Thanos
Published: February 2021

At a time where delivering the best quality of care is the raison d’être
of the health service, outliers can pose a serious challenge to both
clinicians and policy makers. Methods of outlier detection are highly
variable. The collection and assimilation of outcome variables can also
be very challenging. Despite this, the publication of surgeon specific
data has brought the concept of outliers into the public eye and the
consequent punitive action affected upon surgeons can be deleterious to
clinician psychology and patient perception. Simultaneously, positive
outliers are rarely mentioned and never rewarded. Moving forward, the
use of more objective outcomes, including novel biomarkers and
patient-centred data, as well as innovative statistical strategies and
management cultures, can positively evolve the healthcare paradigm for
the future.
Editorial
Authors: Dobric Silva
Published: February 2021

nema
IMPLEMENTING PEDAGOGICAL CONDITIONS OF FORMATION OF FUTURE PILOTS’ READINESS TO INTERCULTURAL INTERACTION
Authors: Martynenko Nadiia
Published: February 2021

The need to prepare future pilots for intercultural interaction is related to globalization and integration processes, the requirements of international organizations and the factor of flight safety. It is stated that in flying institutions of higher education insufficient attention is paid to preparation for intercultural interaction, therefore it is necessary to develop purposeful pedagogical measures on formation of future pilots’ readiness to intercultural interaction. This article reveals the problem of preparing future pilots for intercultural interaction. The aim of the research is to define various methods of implementing pedagogical conditions of formation future pilots’ readiness to intercultural interaction. To achieve the purpose of the researching we have used the methods of analysis, synthesis, comparison and generalization of native and foreign psychological and pedagogical sources on the problem of forming future pilots’ readiness to intercultural interaction. The theoretical analysis of scientific research made it possible to identify the following pedagogical conditions for the formation of readiness of future pilots for intercultural interaction: the formation of value orientations through the creation of a positive psychological climate; team work organization in the process of learning professionally oriented disciplines; integration of the culturological aspect into professionally oriented disciplines; stimulating of reflexive attitude to the process of formation of intercultural interaction qualities. To implement the pedagogical conditions of future pilots’ readiness to intercultural interaction, we offer the introduction of various methods, such as: interactive methods, projects, video games, ice-breaking exercises, training, case study, role-playing games, brainstorming.
Literature and History: Rethinking Representations of the Regimes of Juan Manuel de Rosas and Juan Domingo Perón
Authors:   , Morgan Rachel
Published: February 2021

For many decades, Argentina’s former populist President Juan Domingo de Perón has been frequently compared with the infamous nineteenth-century Federalist dictator Juan Manuel de Rosas. The official liberal historical perspective postulates that the Perón government was the ‘second tyranny’, the first being the notorious Rosas regime, but this assertion is problematic. Despite the evident parallels to be drawn, both men’s zealous supporters and archenemies use the similarities to reinforce their own political agendas. This thesis explores the plausible comparisons between Argentina’s most polemical political leaders, focusing on the literary representations of both figures in a series of nineteenth and twentieth-century fictional and historical works. Studying Rosas and Perón is even more significant in view of the striking similarities between their wives, who were instrumental in elevating their husbands to long-term political supremacy. Both women assumed unofficial roles in their spouses’ administrations and one, namely Eva Perón, is arguably Argentina’s most celebrated political icon. The parallels between both men and women have – strangely – never undergone literary treatment. This study provides the first comprehensive analysis of the four most controversial political figures who have influenced much of the historiography of Argentina.
Examen de la représentativité à l’échelle municipale de la cohorte de l’Étude longitudinale canadienne sur le vieillissement (ELCV) : une analyse des données de référence des participants de Calgary
Authors: Norberg Samantha J. , Toohey Ann M. , Jones Sian , McDonough Raynell , Hogan David B.
Published: February 2021

Introduction

L’Étude longitudinale canadienne sur le vieillissement (ELCV) est une ressource riche, représentative de la population à l’échelle nationale et utilisable à de multiples fins. Même si les municipalités pourraient vouloir utiliser les données de l’ELCV pour répondre à certains besoins stratégiques locaux, on ne sait pas dans quelle mesure les cohortes de l’ELCV sont représentatives des populations à l’échelon municipal. Calgary, ville située en Alberta, étant l’un des 11 sites de collecte de données de l’ELCV, nous avions comme objectif d’examiner dans quelle mesure l’échantillon sur Calgary tiré de l’ELCV était représentatif de la population générale de cette ville en ce qui concerne certaines variables sociodémographiques.

Méthodologie

Les caractéristiques de référence (le sexe, l’état matrimonial, l’origine ethnique, le niveau de scolarité, le statut vis-à-vis de la retraite, le revenu, le statut vis-à­vis de l’immigration, la migration interne) des participants à l’ELCV du site de collecte des données de Calgary entre 2011 et 2015 ont été comparées à des profils analogues tirés des ensembles de données de l’Enquête nationale auprès des ménages (ENM) de 2011 et du recensement de 2016, qui couvrent les années pendant lesquelles les données sur les participants à l’ELCV ont été recueillies.

Résultats

Les participants de Calgary à l’ELCV étaient représentatifs de la population de Calgary pour ce qui est de l’âge, du sexe et de l’identité autochtone. Des écarts de plus de 5 % par rapport à l’ENM ou au recensement de 2016 ont cependant été observés en ce qui concerne l’état matrimonial, les éléments associés à la diversité ethnique (c.­à­d. le statut vis­à­vis de l’immigration, le lieu de naissance, la langue non officielle parlée à la maison), la migration interne, le revenu, la situation vis-à-vis de la retraite et le niveau de scolarité.

Conclusion

Les responsables des études volontaires ont de la difficulté à recruter des cohortes véritablement représentatives. Les collectivités qui choisissent d’utiliser les données de l’ELCV à l’échelle municipale, que ce soit à Calgary ou dans les 10 autres sites de collecte de données, devraient être prudentes lorsqu’elles interprètent les résultats de ces analyses car les participants à l’ELCV pourraient ne pas être parfaitement représentatifs de la population locale en ce qui concerne certaines caractéristiques d’intérêt.
Kajian Paket Dosis Semi Organik terhadap Sifat Tanah dan Hasil Tanaman Padi (Oryza sativa L)
Authors: NARKA I WAYAN , DIBIA I NYOMAN , ATMAJA I WAYAN DANA
Published: February 2021

The study of packages of semi-organic fertilization on soil properties, and yield of rice (Oryza sativa L). The aim of this study was to know the effect of semi organic fertilization doses on soil properties and yield of rice. The Randomized block design (RBD), with 3 replications and 9 treatments was used in this study. P0 (without fertilizer), P1 (25 tons of organic fertilizer ha-1), P2 (300 kg of Urea ha-1, 150 kg SP36 ha-1 and 75 kg KCl ha-1), P3 (biourin liquid fertilizer) P4 (½ P1 + ½ P2), P5 (½ P1 + ½ P3, P6 (½ P2 + ½ P3), P7 (2/3P1 + 1/ 3 P2) and P8 (2/3P3 + 1/3P2). The results showed that the application of semi-organic fertilizer on soil properties such as soil salinity, C-organic content, P-available and Nitrogen content of soil significantly affected by the treatment, while potasium_available and soil pH is not significantly affected by the treatment.  Yield of rice had a very significant effected by treatment. The semi-organic fertilizer P4 (combination of 50 % anorganic + 50 % organic compost) and P6 (combination of 50 % inorganic + 50 % biourine) can produce oven dry grain 33.35 g per bushel and 32.63 g per bushel respectively or increased 57.91 % and 54.50 % of controls.
Kinerja Teknologi Budidaya Jagung Hibrida di Indonesia
Authors: HASTINI TRI , NOVIANA IRMA
Published: February 2021

The performance of hybrid maize cultivation technology in Indonesia. Maize is the most important crop after rice. Beside as a food, maize has other functions as forage and raw material of bioethanol. In Indonesia, the need of maize increases every year. To fulfil the need, an appropriate breakthrough that can increase maize production significantly,  is required. The  most  popular  breakthrough  is the  use  of hybrid variety, that is the first generation derived from two or more pure lines crossing. This review discusses the results of hybrid maize researchs and assessments at various types of agroecosystem. Maize hybrid variety planting accompanied by the appropriate location specific technologies could increase maize productivity significantly.
INVITACIÓN A LA OSCURIDAD Y A LO SUBTERRÁNEO
Authors: Cabrera Daniel H.
Published: February 2021

El presente ensayo constituye una reconsideración de las significaciones sociales desde la importancia de los significados abandonados y olvidados. Se sugiere la posibilidad de apostar a dos metáforas —oscuridad y subterráneo— como forma de repensar la metafórica lumínica con la que se habla del pensamiento desde antiguo.
LA PERSISTENCIA DEL YO. IDENTIDAD PERSONAL E INMORTALIDAD
Authors: Guerra López Rodrigo
Published: February 2021

En la presente investigación se busca ofrecer una hipótesis sobre una de las cuestiones fundamentales del ser humano: la posibilidad de la existencia del yo personal aún después de la muerte corporal. Através de una serie de argumentaciones estrictamente acordes a los datos de la experiencia, y al margen de fe religiosa alguna, se demuestra que el yo posee una fuente de unidad que porta una naturaleza que no puede ser explicada por la simple materia. El yo posee una razón de persistencia metaempírica y unidad indivisible que le permite unificar y trascender los múltiples cambios que se dan en su sustancia manteniendo así su identidad personal.
RÉPLICA A “LA PERSISTENCIA DEL YO” DE RODRIGO GUERRA
Authors: García de la Sienra Adolfo
Published: February 2021

En su artículo “La persistencia del yo: ensayos sobre la inmortalidad del alma” (en este volumen) RodrigoGuerra presenta una serie de argumentos en favor de la inmortalidad del alma. Esta réplica asevera que dichos argumentos son convincentes sólo para aquellos para quienes las premisas son admisibles. Como la admisibilidad de las premisas depende del motivo religioso que anima al escucha, se concluye que los argumentos carecen de efectividad apologética.
LA CIUDAD SUSTENTABLE COMO ENTORNO CLAVE DE LA TECNOSFERA DE LA SOCIEDAD DEL CONOCIMIENTO
Authors: Hernanz Moral José Antonio , Winfield Reyes Fernando Noel
Published: February 2021

El espacio antropológico típico de la sociedad del conocimiento es el urbano tanto por ser el que acumula la mayor parte de la población humana como por ser el más propicio para una economía y una política basadas en el conocimiento. Precisamente por ello, uno de los retos más relevantes para el urbanismo contemporáneo es el diseño y realización de ciudades sustentables. Ahora bien, la idea de una ciudad sustentable es solidaria con un cierto tipo de concepción de la relación cultural entre biosfera (naturaleza) , noosfera (pensamiento) y tecnosfera (acción humana) ; por todo ello, en este artículo se explora la caracterización de la idea de sustentabilidad dentro de la perspectiva más amplia de la tecnosfera de la sociedad del conocimiento.
¿ES POSIBLE UNA FUNDAMENTACIÓN DE LA ÉTICA?
Authors: Aizpún Bobadilla Teresa
Published: February 2021

En todas la épocas antropología y cosmología, es decir la interpretación que la ciencia hace del hombre con la interpretación del cosmos están en corcondancia. Este trabajo está actualmente por hacer. Las llamadas ciencias naturales han avanzado de forma espectacular en el último siglo, pero la antropología sigue anclada en los conceptos del racionalismo positivista de la Modernidad. La adecuación es una asignatura pendiente.
Introducción
Authors: García de la Sienra Adolfo , Lorenzano Pablo
Published: February 2021

Introducción
¿PUEDE LA NEUROTEOLOGÍA SER CONSIDERADA UNA DISCIPLINA CIENTÍFICA?
Authors: Martín Gaitán Leandro
Published: February 2021

En el presente artículo se procura definir el estatuto científica de la "neuroteología". Las razones más importantes por las que se plantea dicho problema :son a) las dificultades que entraña su objeto de estudio; b) su supuesta evocación de la frenología; c)los objetivos que persigue, y d) sus limitaciones metodológicas. No obstante, se sugiere que la neuroteología, a pesar de las lagunas e inconsistencias propias de una disciplina emergente, tiene bases epistémicas suficientemente definidas para ser tipificada como "ciencia".
¿DEMUESTRA SÓCRATES LA INDEPENDENCIA DE LA MORAL EN EL EUTIFRÓN?
Authors: Baumann Pierre
Published: February 2021

Este trabajo arguye que la famosa demostración de Sócrates en el Eutifrón de la no-identidad de lo piadoso y lo amado por los dioses no es filosóficamente convincente, aunque sí es lógicamente correcta; aunado a esto, se formaliza el argumento de Sócrates y se identifican varios problemas con sus premisas principales.
AFECTIVIDAD Y COGNICIÓN. HACIA UNA NUEVA IDEA DE AGENTE EPISTÉMICO
Authors: Ponce Miotti Ana Luisa
Published: February 2021

En el ámbito de la epistemología, la manera de entender el vínculo entre efectividad y cognición ha sufrido transformaciones importantes a partir de las cuales lo central ya no es la racionalidad de la efectividad sino la afectividad de lo racional. Nuestra propuesta busca incormporarse a estos trabajos y tiene como objetivo esbozar la manera en que creemos se establece este vínculo entre afectividad y cognición.Para esto, en un primer momento expondremos, de manera general, qué entendemos por afectos, estableciento una cierta analogía entre afectividad y percepción. A partir de este primer desarrollo, consideremos la manera en que la afectifividad interactua con otros estados cognitivos, en particular, con las  creencias.Este tratamiento otorgará, como resultado último, una visión particular de los procesos cognitivos, los cuales son ejercidos por un agente complejo y situado en una determinada práctica epistémica.
LA HERMENÉUTICA ANALÓGICA COMO TEORÍA DE LA ACCIÓN HUMANA
Authors: Quesada Julio
Published: February 2021

En este texto, se expone una comprensión del trabajo de Mauricio Beuchot, Tratado de hermenéutica, en el que, contrastándolo con el trabajo y pensamiento de Heidegger, brinda una aproximación a lo que se conoce como Analogía Hermenéutica. Con esto, se muestra lo evidente de los alcances de la conciencia filosófica liberal humanista y que a su vez han desintegrado diversos cortes antifilosóficos gestados en el siglo XX. Nociones de identidad e interpretación del otro como paradigma de interconexiones para construir nuestra propia cultura. También se evidencian las faltas o errores en la interpretación de la obra de Heiidegger por diferentes autores, que lo asumieron como deconstructor siendo en realidad un destructor. Finalmente, se presenta a la Hermenéutica Analógica como un nuevo panorama de pensamiento en el que tiene como cimientos a la verdad, la libertad y la felicidad, para demostrar que el mundo sí tiene sentido.
Lo absoluto hegeliano como condición de posibilidad del pensamiento puro. libertad, autoconciencia y experiencia en Hegel
Authors: Gutiérrez Pozo Antonio
Published: February 2021

Este artículo muestra cómo el pensar que se piensa a sí mismo de Aristóteles se realiza plenamente en la idea hegeliana del espíritu como absoluto. La conciencia es autoconciencia si el sujeto de esa conciencia es un sujeto absoluto, el pensamiento puro del espíritu que disuelve toda oscuridad. Sólo este pensar puro es libre, absolutamente independiente. La experiencia de la conciencia como manifestación del espíritu es su movimiento de autoconocimiento y autorrealización. Esta fenomenología del espíritu es el ser del espíritu y el despliegue de lo absoluto. El verdadero ser del espíritu se realiza en su saberse a sí mismo. Por eso lo absoluto y el saber de lo absoluto es lo mismo. El absoluto no es un ser trascendente sino que sólo existen en nosotros, en la autoconciencia intersubjetiva.
En principio era el Verbo. Una aproximación a las relaciones entre Literatura y Filosofía, con la Crítica de la razón práctica y Crimen y castigo como pretexto.
Authors: Gómez Cabia Fernando
Published: February 2021

El presente ensayo parte de las relaciones cercanas que siempre se han dado entre la filosofía y la lteratura, para ello se estableceran una serie de correspondencias entre dos obras universales de la filosofía y la literatura: la Crítica a la razón práctica de Kant y Crimen y castigo deDostoyevski, porque la filosofía y la literatura, en definitiva, son herramientas para cavar distintos sectores de la misma huerta, la del desasosiego del Hombre.
Metafísica rosminiana y “metafísicas” contemporáneas
Authors: Tadini Samuele
Published: February 2021

El ensayo busca evidenciar el objetivo de la metafísica rosminiana y la importancia de su configuración en el contexto de un diálogo crítico con algunas posiciones contemporáneas. El renacimiento del interés por el pensamiento metafísico en estos años y, también, la marginalidad a la que se ha relegado la Teosofia rosminiana, son los puntos fundamentales desde los cuales partir para proponer el discurso metafísico en el centro del debate internacional.
RANDOM COMMODITY FORM OF EXCHANGE: BARGAINING
Authors: Ishunov Vjacheslav
Published: February 2021

A distinctive feature of the random form of trade is the absence of external prices. Determining the zero cost on their own, economic actors put benefits in it only for themselves. As a result, in the act of exchange, its participants had to take into account the interests of the counterpart. The process of harmonization of interests proceeded in the form of bargaining. Possession of the zero-value equation for both exchange participants makes it possible to scan the bargaining process in detail and identify all potential options for the exchange ratio.