bluuebunny/crossref_metadata_2025 huggingface dataset:
Functionalized Morpholine-thiazole Scaffold: Synthetic Strategies and
Applications
Authors: Ali Tarik E. , Assiri Mohammed A. , Alqahtani Maha N.
Published: July 2023

The thiazole derivatives as important members of heterocyclic compounds have attracted much synthetic interest due to their different biological properties. In recent years, studies on the syn-thesis of morpholine compounds have increased because of the properties of this core. In particular, the hybrid structures in which the thiazole ring is linked to morpholine nuclei in one molecular frame have gained popularity. The presented review is an attempt to summarize a huge volume of data on morpholinothiazoles being a widely studied class of these molecules used in modern organic and me-dicinal chemistry. The manuscript covers the approaches to the synthesis of the morpholinothiazoles derivatives. The synthetic strategies of the target compounds depend on one-pot or multistage reac-tions or the transformation of other related heterocycles. Additionally, we covered the biological ac-tivities and other applications of certain morpholinothiazoles. The information on these compounds made special consideration of medicinal chemists to yield a combinatorial library and carry out thor-ough efforts in the search of morpholinothiazoles.
Nutritional and Herbal Supplements for Weight Loss Management:
A Review
Authors: Nannar Ajay R. , Shendge Raosaheb S. , Salunkhe Kishor S.
Published: July 2023

Millions of dollars have been spent on nutritional and herbal supplements, which are
used by many overweight people to lose weight. However, there are concerns about the effectiveness
and safety of several supplements. By boosting energy expenditure, satiety, fat oxidation, inhibiting
dietary fat absorption, moderating carbohydrate metabolism, raising fat excretion, increasing
water elimination, and improving mood, supplements are thought to aid in weight reduction.
This study provides an overview of the present status of the research on a few particular dietary
supplements, herbal combinations, and combination products, as this field is evolving quickly.
More studies on numerous supplements are required to verify their efficacy because they have not
been examined in randomised controlled trials. Nutritionists and medical experts should go through
dietary supplement use with patients and notify the FDA of any negative side effects. Additional
rules would be required for the manufacture, sale, and marketing of these supplements.
Nontuberculous Mycobacterial Infection Mimicking Lung Cancer in a Patient
with Usual Interstitial Pneumonia Pattern Interstitial Lung Disease: A Case
Report
Authors: Lee Chaebin , Park Jongsoo , Lim Jae-Kwang , Park Jongmin , Park Byunggeon
Published: July 2023

Background:

It has been reported that structure damage in the parenchymal lung disease such as idiopathic pulmonary fibrosis (IPF) is associated with high susceptibility to nontuberculous mycobacterial (NTM) infection. Radiologic features of NTM lung disease in destructive lung parenchyma can be atypical, which can cause confusion with other diseases including malignancy. Prompt and accurate identification of newly developed lesions in the follow-up computed tomography (CT) of IPF patients is challenging but crucial.

Case Report:

We reported a case of an NTM infection in a patient with IPF, manifested as a mass-like consolidation with cavitation on chest CT, mimicking lung cancer.

Conclusion:

Being aware of the unusual radiologic features of NTM lung disease in IPF patients can be useful in the differential diagnosis of newly detected lesions.
Tizanidine Induced Hypotension: Report of a Case and Review of the
Literature
Authors: Mahajan Roopali , Kalita Jayantee
Published: July 2023

Introduction:

Spasticity is a common sequelae of stroke, and often these patients receive
anti-spastic drugs such as baclofen or tizanidine. Stroke patients have multiple co-morbidities
such as hypertension, diabetes, and seizure. Tizanidine is an α2 and imidazole receptor agonist at a
spinal and supraspinal level resulting in reduced central sympathetic outflow and causing hypotension
rarely, especially in those receiving beta-blockers or angiotensin-converting enzyme inhibitors.

Case Presentation:

We report a 56-year-old hypertensive male presenting with altered sensorium
who had recurrent intracerebral hemorrhage with left spastic hemiplegia and focal seizures.
He was on amlodipine, atenolol, telmisartan and oxcarbazepine. After 3 doses of tizanidine 2mg,
his blood pressure dropped from 140/90 to 80/40 mmHg and pulse from 82 bpm to 44 bpm. His
blood counts, serum chemistry, procalcitonin, and Trop I were normal. ECG revealed sinus
bradycardia. After 8 hours of withdrawing tizanidine, his blood pressure became 110/70 mmHg,
and on the next day, it became 140/82 mmHg. His attendants were taught physiotherapy to minimize
spasticity.

Conclusion:

This patient highlights the need for close monitoring of patients receiving tizanidine
co-medication with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers.
These drugs have a synergistic effect on reducing the renin-angiotensin-aldosterone system, thereby
hypotension and bradycardia.
Study of the Analgesic Potential of the Ethanolic Extract of Moroccan
Cistus ladanifer L.
Authors: Adadi Imad , Ayadi Rachida El , Hajji Lhoussain , Eddouks Mohamed , Ibaoui Hamid El
Published: July 2023

Aims:

The study aimed to analyze the analgesic activity of Cistus ladanifer L.

Background:

Cistus ladanifer L. is a fragrant shrub of the Cistaceae family widespread in the Mediterranean
basin, it has various biological activities, including antidiabetic and antihypertensive effects.

Objective:

The objective of this work was to study the phytochemical profile, the acute toxicity and
the analgesic power of the ethanolic extract of the species Cistus ladanifer L. (C. ladanifer) collected
in Northern Morocco.

Methods:

The evaluation of antinociceptive activity in mice was performed using two validated
models, the formalin-induced paw-licking model and the acetic acid-provoked writhing test.

Results:

According to the results, five phenolic compounds were identified in the ethanolic extract
by HPLC-MS/MS. As regards the acute toxicity study, the results showed no mortality or clinical
symptoms in mice treated to compare the control group at doses up to 5,000 mg/kg BW. Regarding
the analgesic effect, the ethanolic extract at the doses of 400 and 800 mg/kg, BW showed a statistically
significant (p <0.05) and dose-dependent analgesic effect in two nociceptive tests. On the other
hand, in the syrup of ethanolic extract at the dose of 800 mg/kg, BW expressed the most superior
pain-inhibiting effect in both tests, producing an analgesic effect equivalent to that of the reference
drug (indomethacin).

Conclusion:

These findings provide pharmacological justification that might aid in the development
of a natural anti-nociceptive medication as an alternative to chemical analgesic drugs.
Research on Typical Fault Diagnosis of Gear based on GHM Multiwavelet
Transform and MCKD Algorithm
Authors: Zhang Hongxin , Ji Zhongshu , Song Ruijin
Published: July 2023

Background:

Gear is the key part of the transmission part of mechanical equipment, which has a high failure rate under complex working conditions or long-term operation, directly affecting the reliability of mechanical equipment. To realize online monitoring of gears and predict gear faults, whether the diagnosis of typical gear faults is accurate and timely is a key link, so it is necessary to study the diagnosis of typical gear faults.

Objective:

This paper aims to propose a method that can effectively diagnose typical faults of gears and is easy to program, which is beneficial to realize online monitoring of rotating machinery equipment faults.

Method:

A typical gear fault diagnosis method based on GHM multiwavelet transform and maximum correlation kurtosis deconvolution algorithm (MCKD) is proposed in this paper. The measured vibration signal is decomposed into components with multiple scale spaces and frequency bands through the GHM multiwavelet transform. Then, the MCKD algorithm is run to suppress the noise of GHM multiwavelet transform coefficients, and the periodic components containing fault information are retained and reconstructed. The typical faults such as gear pitting and broken teeth are tested.

Results:

GHM multiwavelet transform combined with MCKD algorithm can accurately locate the frequency band containing fault information from the vibration signal with multiple modulations, double sideband, and multi-frequency interference and effectively extract the fault frequency and its frequency multiplication. The root means a square error of the extracted fault frequency is 0.08. This method has a good noise suppression effect and high accuracy in extracting fault frequency.

Conclusion:

The method proposed in this paper is helpful in realizing automatic programming of gear fault diagnosis and is of great significance in realizing real-time monitoring and online diagnosis of rotating machinery equipment faults. More related patents will appear in the future.
DoE Enabled Development and In-Vitro Optimization of Curcumin-tagged Cilostazol Solid Nano Dispersion
Authors: Rawat Aruna , Jhawat Vikas , Dutt Rohit
Published: July 2023

Background:

Diabetes is a prevailing disease worldwide and its complications are also hazardous including nephropathy. Drug available to treat Diabetic Nephropathy (DN) faces bioavailability issues related to solubility and absorption of drugs. Cilostazol (CLT) is a BCS class II drug that is poorly water-soluble which affects its therapeutic efficacy. CLT reduces reactive oxy-gen species (ROS) increased in DN. Curcumin (Cur) is also hydrophobic but Cur has many therapeutic efficacies like anti-inflammatory and antioxidant properties that help for the treatment of DN.

Objective:

The objective of the current study was to develop and optimize the Cilostazol Solid Dis-persion Nanoparticle (SDN) to improve the bioavailability of the drug by tagging it with Cur by us-ing PVP VA S 630 as polymer and Poloxamer 407 as surfactant.

Method:

Different formulations were developed using the emulsion solvent evaporation method, PVP VA S 630 as the hydrophilic polymer, and Poloxamer 407 as a surfactant. Two-factor, three-level Box-Behnken Design (BBD) was used for statistical analysis of the selected process variable's main effect and interactive effect on the response. Curcumin tagging was also done for the entire batches. Nanoparticles were characterized by FT-IR spectroscopy, DSC, Particle size, Zeta poten-tial, Drug entrapment efficiency, Solubility, and % CDR studies.

Results:

Among the 17 different formulations (CLT1-CLT 17), with a solubility of 39.5 μg/ml, a % CDR of 99.55, a typical particle size of 219.67 nm with a PDI of 0.258, entrapment efficiency of 73.47%, and a -10.6 mV of Zeta potential, CLT-15 was optimized. To determine CLT and curcu-min, the simultaneous UV calibration method was created. Overall, the DSC study indicated the amorphous nature of the Nano Dispersion, which in turn means the successful entrapment of the CLT in the Nano Dispersion matrix. TEM images also confirmed the spherical nanoparticles. The optimized batch of drugs tagged with curcumin was compared with the plain drug Solid Dispersion Nanoparticles.

Conclusion:

Together with the molecules of curcumin, the solid nano dispersion of CLT was pro-duced, which will add to the benefits of the management of Diabetic Nephropathy. In the current study, we underline the importance of utilising both API and phytochemicals in the treatment of Di-abetic Nephropathy, and we anticipate further basic research or clinical trials to support innovative treatments. It is possible to use these matrix-forming polymers for active ingredients with poor sol-ubility, whether they are natural or synthetic. It has also been demonstrated that these carriers (PVP VA S 630 & Poloxamer) increase the dissolution rate (in-vitro).
Exploring the Traditional System of Medicine With Special Emphasis on the Indigenous Practice of Herbal Remedy by the Tribals of North-East India
Authors: Kumar Suman , Kushari Susankar , Sarma Himangshu , Laloo Damiki
Published: July 2023

The tribal people of India consider North-East India to be a hotspot. It contains eight states: Arunachal Pradesh, Assam, Manipur, Mizoram, Meghalaya, Nagaland, Tripura and Sikkim, and it borders international boundaries with Bhutan, Tibet, China, Burma and Bangladesh. The Indo-Burma biodiversity hotspot, which is home to a broad spectrum of unusual flora, fauna and microorganisms, is located in the Northeast Region. The region has the evergreen forest of the Brahmaputra River valley, wide leaf forest, dense bamboo and pine forest and the world's wettest location (Cherrapunji and Mawsynram), all of which help to maintain the region's unique biodiversity. North East region is the inhabitant of more than 145 significant tribal communities with the most dominating primitive societies, including the Abor, Mishing, Rabha, Khasi, Kuki, Naga, Meitei, Apatani, etc. Most of these communities are culturally and linguistically diverse. The NER's tribal population is literate compared to other parts of the country, and it's worth noting that the literacy rates in Mizoram, Meghalaya, Nagaland, Sikkim and Manipur are all higher than the national average. Despite their high literacy rate, India's North-Eastern states continue to have poor transportation, power and medical services. The healthcare system is in bad shape, with only a few hospitals and nursing homes. As a result, the people residing in this area rely exclusively on a traditional system of medicines made by traditional healers from plants, animals and mineral resources. It was stated that medicinal herbs are prepared using traditional methods, such as maceration, decoction, and infusion, either alone or in combination with other plants. The key species of medicinal plants often employed by the traditional healers of the region are Acorus calamus, Aegle marmelos, Asparagus racemosus, Averrhoa carambola, Bryophyllum calycinum, Costus speciosus, Euphorbia neriifolia, Justicia adhatoda, Melia azadarachta, Plumeria acutifolia, Sida cordifolia, Sida rhombifolia and Swertia chirata. This extensive work will aid the researcher in locating previously unknown medicinal plants in order to build a new therapeutic method for isolating new chemical entities that are safe, pharmacologically active, and cost-effective.
Ethnobotanical use of Ayurveda to Treat COVID-19-Induced Respiratory Disorders
Authors: Pathak Manish , Kumar Pandey Rupesh , Kumar Sokindra , Singh Lubhan , Prasad Mishra Ganesh , Kumar Amit , Dubey Swati , Shankar Shukla Shiv , Kumar Pandey Ravindra
Published: July 2023

Respiratory tract infections are a major health problem in the entire world,
especially due to corona epidemic in late 2019. Coronavirus spread-out throughout the
world, and it causes the death of millions of people due to the precipitation of severity
in respiratory disorders like respiratory neuromuscular, pulmonary vascular, and lung
parenchymal disorders. All are the characteristic features of COVID-19 infection. The
aim of the present review work was to summarize all existing ethnobotanical data on
ayurvedic medicinal plants used in the treatment or management of respiratory
disorders. Many known plant species are traditionally used to treat respiratory disorders
& some plant species have been investigated for their therapeutic efficacy with positive
results. This present study explored various offline & online databases for the literature
on ayurvedic medicinal plants used worldwide to treat & manage respiratory disorders.
A total number of 205 ayurvedic plant species used to treat & manage respiratory
disorders worldwide has been documented. Most of the plants belong to Solanaceae,
Asteraceae, Amaryllidaceae, Lamiaceae & Malvaceae.
A Comprehensive Review on Anticancer and Antitumor Potentials of Indigenous Plants Found in North East India
Authors: Medhi Arundhati , Malakar Rupshikha , Bhuyan Birina , Deka Sawrajyoti , Adhikary Kalyani
Published: July 2023

Cancer is a malign disease that accounts for about 9.6 million deaths around
the world and is the second largest leading cause of death after cardiovascular disease.
Chemotherapeutic drugs administered to treat cancer show great potency but falter,
causing many severe side effects. Hence, the paradigm of cancer drug research has
shifted towards plant and plant-derived natural compounds as they are reported to
deliver maximal effectiveness with lesser side effects. Indigenous plants and their
derivatives have been an integral part of ethnomedicine in India. The traditional
knowledge of utilizing medicinal plants has been used to treat numerous metabolic
disorders and diseases since immemorial. Indigenous plants have also been shown to
possess high potency in the treatment of cancer as well. The natural landscape of
northeast India has some of the most diverse and unique plant species, which have been
traditionally used in ethnomedicine and have been studied for their anticancer and
antitumor potentials. The aim of the present review is to highlight some of the natural
and indigenous plant species of Northeast India that have been reported to have anti-cancer and anti-tumor effects identified either in-vivo or in-vitro.
Chitosan-Based Nanoparticles in Tissue Regeneration
Authors: Katas Haliza
Published: July 2023

Chitosan is a unique polymer owing to its cationic property that allows
interactions with various biological entities and is subsequently produced into novel
functional products for biomedical applications, including tissue regeneration. Its
cationic nature is conferred by amino groups present in its structure that are also
responsible for various properties, including antibacterial activity. Chitosan is a
biomaterial that has been extensively used in tissue engineering due to its ability to
facilitate three-dimensional (3D) cell growth and proliferation as well as organize the
deposition of collagen, the important processes in wound healing. Moreover, chitosan
is a biocompatible and biodegradable polymer, making it an outstanding material for
tissue engineering applications. Besides, chitosan possesses biological or
pharmacological activities such as hemostatic, antioxidant, antimicrobial, and anti.inflammatory, further expanding its biomedical applications. In tissue engineering,
chitosan has been developed as scaffolds in the form of membranes, sponges,
nanofibers, and hydrogels for treating various tissue damages. They are used to provide
a suitable environment for supporting the growth of cells. In combination with
nanotechnology, chitosan is converted into nanoparticles that possess unique properties
and hence, they have been utilised in wound healing, cartilage, and bone regeneration.
This chapter highlights the roles of chitosan-based nanoparticles in tissue regeneration
along with their recent developments.
Wound Healing Utilizing Electrical Stimulation Technique: Towards Application of Dielectrophoresis
Authors: Mohd Maidin Nur Nasyifa , Deivasigamani Revathy , Ramdzan Buyong Muhamad , Mohd Som Nor Aina , Mohamed Mohd Ambri
Published: July 2023

Diabetes is a metabolic disorder characterised by long-term hyperglycemia
caused by insulin resistance [1]. According to scientific studies, the number of people
with diabetes climbed from 30 million in 1985 to 177 million in 2000 and is expected
to increase to 552 million by 2030 [2, 3]. Diabetic patients suffer from impaired or
delayed wound healing due to a few factors leading to the development of chronic
wounds. Chronic wound management is becoming an economic burden on the
healthcare system. With the rising prevalence of chronic diabetic wounds, finding
effective treatment strategies and advancing therapy are critically important. Although
the exploration of electrostimulation therapy for wounds is only very recent, it is a
promising approach to expedite wound healing. With recent advancements in wearable
device technology, a new treatment strategy that integrates electrical stimulation and
biomaterial dressing has been adopted.
Nanobio-Inspired Materials for Tissue Engineering
Authors: Bidyaleima Chanu Naorem , Ningthoujam Rina , Jayasekhar Babu Punuri , Disco Singh Yengkhom
Published: July 2023

The utilization of nanoscale biomaterials in various fields of modern science
has shown great change and benefits in this present era. Due to their unlimited
potential, many researchers have focused on further studies, and today, they play a
good role in human health improvement programmes. Accordingly, it is true that the
use of nanomaterials in tissue engineering is one of the most advanced technologies in
medical care. The technology which integrates materials science and engineering with
biology in order to improve the induction of tissue regeneration is called tissue
engineering. This technology helps in controlling the cellular combined with
synthetically engineered materials and is used for various treatments. One of its main
functions is the treatment of structurally degenerated organs in the human body. Tissue
engineering techniques can be upgraded with distinct properties of nanomaterials like
better adaptability, good response, delivery potential, and better controllability.
Moreover, unlike other materials, they are highly efficient, reliable, and easily
decompose. Depending on the type of application, different kinds of nanomaterials are
used, such as polymers, metals, ceramics, and their various compositions.
Consequently, it can be assumed that the approaches of incorporating nanomaterials in
tissue engineering will enhance the disciplines of tissue regeneration.
A Use of Nonlinear Coefficients in Ordinary Differential Equations of Mathematical Models of Electrical Devices Describing Inductance vs Current or Magnetic Flux Linkage Relationships
Authors: Pustovetov Mikhail , Shukhmin Konstantin
Published: July 2023

When mathematical models of electromagnetic devices are described by
ordinary differential equations, then the magnetization curves of their cores are often
expressed with a help of nonlinear coefficients. Sometimes such an approach is
considered questionable, and therefore, the purpose of this chapter is to prove its
admissibility. 
Starting Mode Computer Simulation of Auxiliary Induction Motor Onboard of an AC Electrical Locomotive Equipped with a Capacitive Phase Splitter
Authors: Pustovetov Mikhail , Shukhmin Konstantin
Published: July 2023

This chapter discusses the start-up simulation results of auxiliary drives of
fan and piston-type air-compressor driven by three-phase induction motors. The
computer model described in this chapter simulates a relay-contactor type system of
auxiliary machines powered from the secondary winding of the traction transformer
through the capacitive phase-splitter. The authors make an analytical comparison of the
start-up process at different values of the grid voltages. Comparative assessments of the
simulation-based and experimental oscillograms of voltages, currents and the rotational
speed of the motor-fan and motor compressor during the start-up process are described. 
Anatomical Attributes of the Tooth
Authors: Chowdhry Aman , Kapoor Priyanka
Published: July 2023

Anatomical variations in the human species can be attributed to interactions
between genetic influences and environmental factors. These variations also permeate
dental morphology, and dental morphological traits are of value for understanding
variations among populations. Dental anthropologists have cataloged this diversity, and
these traits have been used in various disciplines.
To establish population-based data, both metric and nonmetric dental trait frequencies
are required. These anatomical attributes have applications in forensic odontology and
archaeological contexts. Both nonmetric and metric traits are being used in the fields of
dental profiling (assessing age, sex and ethnicity) and bite mark analysis.
A trait that is higher in number in one population may be considered normal in the
population. In contrast, if a trait is found at a low frequency, it could inadvertently be
considered an anomaly. It can help in determining the relationship with ancestry, which
justifies the significance of data pools of dental traits in human forensic identification.
Although numerous studies of dental anatomical landmarks and peculiarities have been
carried out in search of population patterns worldwide, India has yet to establish a
database for its population. This highlights the need for an area-specific, gender- and
ethnicity-based database of dental traits for the population of the Indian continent,
which does not exist at present.
Dental Age Estimation in Forensics
Authors: Kapoor Priyanka , Chowdhry Aman
Published: July 2023

Dental age estimation is important in both comparative and reconstructive
forensic identification, where chronological age is either unknown or deliberately
hidden or forged due to criminal, civil or legal disputes. Age estimation is possible
right from prenatal life to early postnatal, childhood, adolescent and adult age, but the
methods or principles differ in implementation. While the developmental stages of
teeth are important to assess age in a young life, the morphologic changes after the
complete development of teeth or third molar indices become important in adulthood.
This chapter classifies different methods used in dental age determination, including
visual, radiographic, physical, histologic, biochemical, and morphologic changes, in
different age groups and gives a diagrammatic representation for ease of understanding.
The evolution of atlas/chart methods for developing teeth has been explained in detail,
including the conventional Schour and Massler chart to the contemporary London atlas
method. Additionally, an overview of the more objective scoring methods, including
Demirjian and its modifications, comprehensive DAEcc charts, Camariere methods,
etc., is also given. This chapter also entails the most recent advances in age estimation
techniques, including 3-D CBCT/micro-CT volumetric assessments and automated age
estimation programs, along with the current use of artificial intelligence (AI) in the
segmentation of radiographic images of teeth for greater accuracy and automation. The
comprehensiveness of this chapter is established by the inclusion of dental age
estimation in special situations of craniofacial abnormalities, archeology or fossil
evidence. Towards the end, it also highlights the importance of using more than one
age estimation method while preparing a forensic age estimation report or in research,
also mentioning the error rate in each method.
“Dental Anomalies”: A Key to Personal Identification
Authors: Kumar Gyanendra , Malik Dutta Shilpa , Rehman Ferah
Published: July 2023

Despite the fact that the world is a lovely spot to live, violations, brutality,
mishaps, and fiascos happen on a regular basis. Being that as it may, distinguishing and
bringing the guilty party(s) to discipline and carrying comfort to the family members of
the person in question or the deceased by recognizing the perished is the best equity we
can manage, and criminological medication assumes a significant part in it. A forensic
examination team might include law implementing authorities- criminological
pathologists, measurable odontologists, legal anthropologists, serologists, criminalists,
and different experts relying upon the conditions. Singular ID may in like manner be
expected to recognize both a lost live presenting with amnesia and the liable gatherings
doing incorrectly doings.
Propagation of supersonic soliton in carbon nanotubes of armchair type
Authors: Shunaev V. V.  , Chetverikov A.P.  , Glukhova O. E.
Published: July 2023

The propagation of a localized ring nonlinear wave in carbon nanotubes (CNTs) of armchair type has been explored using the MD/DFTB method. It is unambiguously shown that the considered localized waves are soliton-type. Herewith, the higher a velocity of an initial perturbation, the higher a steady-state velocity of the considered soliton. It is established that at a high initial excitation energy in a time period of 0.1-0.2 ps the soliton moves at the speed in the range of 245-270 Angstrem/ps, which is approximately in 1.22-1.35 times higher than the speed of sound in CNTs (200 Angstrem/ps). It is shown that the soliton velocity practically does not change with increasing CNT radius Keywords: molecular dynamics, carbon nanotubes, soliton, supersonic wave.
Optimization of gas mixtures of multiband excilamps
Authors: A.M. Boichenko  , Klenovskii M. S.  , E.A. Sosnin  , Tarasenko V. F.
Published: July 2023

The paper considers the problem of optimizing gas-discharge sources of multiband UV radiation --- excilamps. A method is proposed for estimating the ratio of partial pressures of the components of a gas mixture, which makes it possible to simplify the process of developing a multiband excilamp with the desired power ratio of the emission bands. It is shown that the optimization of a multiband excilamp on a mixture of one noble gas with several halogen carriers can be reduced to the problem of optimizing an excilamp on a two-component mixture. If, in addition to the radiation of exciplex molecules, the radiation of excimer molecules is of importance, then the method makes it possible to control the relative contribution of the powers emitted by these molecules. Keywords: gas discharge, sources of ultraviolet radiation, kinetics of plasma-chemical processes, excimer and exciplex molecules.
Computer resonance dynamics of a glycine molecule in an infrared electric field
Authors: Nepomnyashchaya E.K.  , Baranov M.A.  , Tsybin O.Yu.
Published: July 2023

The supercomputer software-computer complex of molecular dynamics is supplemented with an external alternating electric field. Along with nonresonant influences, the mode of resonant excitation of normal vibration modes in the molecules of the amino acid glycine was studied when an electric field was set in the form of a symmetrical meander in the IR frequency range. The technique expands the possibilities of studying the structure, dynamics, and functions of biomolecules, as well as methods for developing hybrid micro and nanoelectronic devices. Keywords: biomolecules, molecular modeling, electronics, molecular vibrations.
Effect of sudden constriction of a flat duct on forced convection in a turbulent droplet-laden mist flow
Authors: Pakhomov M. A.  , Terekhov V. I.
Published: July 2023

Numerical modeling of the flow structure and heat transfer in a gas-droplet turbulent flow in a duct with forward-facing step is carried out. The two-dimensional RANS equations are used in the numerical solution. The Eulerian two-fluid approach is used for describing the flow dynamics and heat transfer in the gaseous and dispersed phases. The turbulence of the carrier phase is described using an elliptical Reynolds stress model with taking the presence of dispersed phase. It is shown that finely-dispersed droplets are involved in the separation recirculation motion of the gas phase. The addition of evaporating droplets to a single-phase turbulent flow in the forward-facing step leads to a significant intensification of heat transfer (more than 2 times) compared to a single-phase air flow, all other parameters being equal. This effect is enhanced with an increase in the initial mass fraction of the water droplets. Keywords: Numerical simulation, Reynolds stress transport model, forward-facing step, droplet evaporation, turbulence, heat transfer enhancement.
Impedance of a thin-film lithium-ion battery Si@O@Al|LiPON|LiCoO-=SUB=-2-=/SUB=- at temperatures from -20-=SUP=-o-=/SUP=-C to +50-=SUP=-o-=/SUP=-C
Authors: Rudy A. S.  , Kurbatov S. V.  , Mironrenko A. A.  , Naumov V. V.  , EgorovaYu. S.
Published: July 2023

The results on measuring the impedance of a solid-state thin-film lithium-ion battery of the Si@O@Al-LiPON-LiCoO2 electrochemical system in the temperature range from -20oC to +50oC are presented. A structural model is proposed and the parameters of its elements, providing the best fit for the experimental Nyquist diagrams, are calculated. It is shown that the main contribution to the internal resistance is made by the LiPON-LiCoO2 interface. Based on the temperature dependence of the LiPON solid electrolyte conductivity the activation energy of lithium is determined, which is in good agreement with the literature data. Keywords: Nanocomposite, lithium-ion battery, impedance spectroscopy, structural model, ionic conductivity.
Prácticas sostenibles para la conservación de suelos en sistemas productivos ganaderos de trópico alto
Authors: Bautista-Montealegre Luis G. , Benavides-Cruz Juan C. , Cardona William A. , Criollo-Campos Paola J. , Torres-Cuesta Daniel R. , Albarracín-Arias Luis O. , Bolaños-Benavides Martha M.
Published: July 2023

Livestock in Colombia is carried out in large areas, in 2022 about 633.841 farms and 29.301.392 animals were reported. Traditional systems with low technology generate a negative impact on soils, affecting physical and chemical conditions. Therefore, it is important to implement management alternatives that guarantee sustainability and profitability. Through an alliance between FAO and AGROSAVIA, the effect of the three systems was evaluated during two periods of time: silvopastoral with an arrangement in a strip-grazing pasture (SPS), silvopastoral with grasslands renewal (GRS), and traditional grazing on grasslands (TS), on physical and chemical properties of the soil. A split-plot experimental design was used, a two-way multivariate analysis of variance (two-way MANOVA) was applied (productive system and sampling time), and an analysis of variance (ANOVA) with a 5% Tukey's test. Using the ArcGIS® Pro 2.9.0 (ESRI®) software, the results of the previously georeferenced samplings were interpolated, using the inverse distance weighting technique (IDW) and the Moran's Index, to verify the type of distribution of the variables influenced by the factors. The MANOVA indicated that individual factors had a significant effect on electrical conductivity (EC), Na, and P, and interaction of factors on Fe, Cu, Mn, particle density (PD), and moisture retention (MR). On the other hand, through the ANOVA, significant differences were identified, registering higher EC, P, MR, and lower PD in SPS, higher content of Fe and Mn in GRS and Cu in TS.
Hongos micorrícicos arbusculares y Trichoderma en Capsicum annuum disminuyen el daño inducido por Meloidogyne incognita
Authors: Basto Pool Carolina Isabel , Herrera Parra Elizabeth , Cristóbal Alejo Jairo , Zavala León Manuel Jesús
Published: July 2023

Consortia of native species of arbuscular mycorrhizal fungi (AMF) and Trichoderma (TRI) strains were evaluated in a greenhouse to control the sedentary endoparasitic nematode, Meloidogyne incognita (Mi) on Capsicum annuum. Plants inoculated with AMF and TRI consortia were inoculated with Mi, and eight treatments were evaluated: i) AMF, ii) TRI, iii) AMF+ TRI, iv) AMF + Mi, v) TRI + Mi, vi) AMF + TRI + Mi, vii) Oxamil nematicide + Mi and viii) Control, with 15 replicates arranged in a completely randomized experimental design. After 166 days, the AMF + Mi treatment resulted in the lowest galling index (53%). The lowest number of eggs was obtained with TRI + Mi and AMF +TRI + Mi with reductions of 68 and 55% with respect to control, and 54 and 37% to Oxamil + Mi. Reduction of females was achieved with treatments AMF + Mi in 11%, TRI + Mi in 42% and AMF + TRI in 61% with respect to control. Treatments without Mi inoculation presented healthy roots and a higher average of agronomic variables. The AMF + Mi, AMF + TRI + Mi treatments, which included nematode inoculation, promoted greater plant growth, with effects equal to those obtained with Oxamil + Mi. The consortia promoted plant growth and exerted antagonistic control effects against M. incognita greater than the nematicide.
Panificación con harinas compuestas de trigo y ahuyama (Cucurbita moschata Duchesne)
Authors: Valdes Restrepo Magda , Londoño Hernández Liliana , Ortiz Grisales Sanín
Published: July 2023

There is a range of processed foods that satisfy hunger, but do not nourish, causing a progressive decline in human health; however, bread enriched with micronutrients has a beneficial effect on health, contributing to the functioning of the organism. The objective of this research was to develop a functional bakery product based on wheat and butternut squash flours from two cultivars; An experimental work with six T0 treatments was proposed: 100% wheat flour (WF) – 0% butternut squash flour (BSF); T1: 80% WF – 20% BSF; T2: 85% WF – 15% BSF; T3: 90% WF – 10% BSF; T4: 95% WF – 5% BSF; T5: 97% WF – 3% BSF and three repetitions per treatment, under a completely randomized design, the chemical, physical and organoleptic properties were evaluated in each treatment by cultivating; for sensory testing, the sensory test was performed. The results indicated that all the treatments have a protein content between 9.59 - 9.78% and total carotenoids between 18.60 - 26.44 µg./g. on a dry basis; the sensory test Friedman established that the best treatment using flour from the Abanico 75 cultivar was T3 for flavor and color characteristics, and T4 for palatability, and when using flour from the Dorado cultivar for the same characteristics, the best treatment was T3 with 10% of butternut squash flour.
Efficacy of In-person and Telepractice Versions of Lee Silverman Voice Treatment on Dysarthria and Dysphagia in Adults with Cerebral Palsy (Preprint)
Authors: Park SangAh , Kim Kyung Min , Hwang Seong Hye , Park Alyssia , Hwang Jihye , Kim HyangHee , Cho Sung-Rae
Published: July 2023

BACKGROUND

The Lee Silverman Voice Treatment (LSVT) has been demonstrated in multiple studies to improve the symptoms of dysphagia and dysarthria in Parkinson’s disease (PD) and other neurological disorders through the process of motor learning and intensive intervention.

OBJECTIVE

Efficacy of intensive voice therapy in improving speech and swallowing functions was investigated in adults with cerebral palsy (CP).

METHODS

Lee Silverman Voice Treatment (LSVT), a speech-behavior therapy, was performed on 16 subjects with CP (men:women= 9:7; mean age= 43.4±10.43 years) via an in-person program of an extended version of LSVT (LSVT-X), and a telepractice program of LSVT-X (LSVT e-LOUD-X). Maximum phonation time (MPT), voice intensity, diadochokinetic rate (DDK), Voice Handicap Index (VHI), swallowing-quality of life (SWAL-QOL), and Videofluoroscopic Dysphagia Scale (VDS) were analyzed before and after the LSVT treatments.

RESULTS

Speech function significantly improved in MPT (P = .006), voice intensity (P = .004), DDK /puh/ (P = .043), and DDK /puh-tuh-kuh/ (P = .031). Swallowing function significantly improved in pharyngeal phase on the VDS. Quality of life was also improved in physical (P = .003), emotional (P = .000), total score of VHI (P = .001), fear (P = .031), sleep (P = .013), fatigue (P = .003), and total score of SWAL-QOL (P = .019). Such improvements were observed in both LSVT-X and LSVT e-LOUD-X groups.

CONCLUSIONS

LSVT-X and LSVT e-LOUD-X are equally effective in improving speech and swallowing functions and related quality of life measures in adults with CP.

CLINICALTRIAL

This study was approved by the Institutional Review Board (No. 4-2021-1009).
SCADA Sistem Pengisian dan Pengepakan Kemasan Multigrain Rice Berisi 2-3 Macam Biji-bijian
Authors: Setiyani Theresia Prima Ari , Kristoforus Adrian , Maretyana Yashinta
Published: July 2023

The process of packing food products manually raises many problems, including inefficiency, quality of hygiene, changing the composition according to market demand, and monitoring, that are difficult to do remotely in real-time. This research builds SCADA for filling and packing Multi-grain rice packages containing 2-3 kinds of grains.The composition of the grain be filled in the package through the HMI. The conveyor moves to carry the packing bags and stops at each grain container. The rotary vane feeder of the container will rotate so that the packaging bag will be filled with grains and then glued together. The position of the packaging bag is detected by 3 pairs of photosensors. The actuator control uses a Schneider M221 PLC via ethernet port. The communication system between the I/O devices and the PLC uses a cable, while the communication between the PLC and the HMI is via the internet network.The system is capable of filling the material according to the desired composition, sealing, and packing to the number of packages. HMI feeds composition input to the system, displays animations correctly, raises an alarm when the material in the tub is running low, and  record production as a daily report.
Educación sexual, familia y escuela
Authors: Contreras Contreras Johana , Rodríguez Parra Mery
Published: July 2023

El profesorado cumple un papel central en la educación sexual integral y muchas veces no tiene la formación necesaria. Adicionalmente, quienes ejercen la docencia se enfrentan a cuestionar sus concepciones sobre la sexualidad y a superar las tensiones con las familias de sus estudiantes. Esta investigación aborda las representaciones sociales de docentes chilenos/as sobre su rol, el de la escuela y la familia en materia de educación sexual. Con una metodología cualitativa, se realizaron entrevistas a 18 docentes pertenecientes a escuelas con características sociodemográficas diferentes. Mediante análisis estructural del discurso fue posible describir las representaciones sobre tres tópicos: el rol de la escuela y la familia en educación sexual; los tipos de educación sexual en función de la relación familia-escuela; y el rol y la formación docente en educación sexual. En la discusión final se interpretan estos resultados y se realizan proyecciones para la investigación y política educativa.
El afrontamiento del COVID-19 en los centros educativos rurales en España (curso 2020-2021)
Authors: Álvarez-Álvarez Carmen , Lavín-Aja Rosana
Published: July 2023

Este estudio trata de conocer cómo han vivido los líderes escolares la incidencia del COVID-19 en los centros educativos rurales en España, dado que todas las escuelas tuvieron que replantear su funcionamiento y organización para afrontar el curso académico 2020-2021. Se diseñó un cuestionario online que fue respondido por 252 miembros de equipos directivos que ejercen actualmente en una escuela rural. Los resultados muestran un gran esfuerzo por parte de toda la comunidad educativa para superar con éxito este curso escolar y adaptarse a los cambios producidos en la forma de trabajar, relacionarse y comunicarse. Algunos aspectos característicos de la escuela rural, como la baja ratio, facilitaron los cambios, pero otros, como las dificultades en las conexiones, han dificultado la actividad educativa en el medio rural.
El proceso de (des)institucionalización de la educación en derechos humanos en Brasil
Authors: Cardoso Fernando da Silva , Tavares Celma
Published: July 2023

This text presents the process of consolidating human rights education (HRE) and its recent de-institutionalization due to the elimination of the National Committee for Human Rights Education in Brazil. To achieve this, we have carried out a theoretical study and an analysis of historical data, documents, and specialized bibliography. We address the historical, political, and regulatory frameworks related to education in this field. Secondly, we present some of the premises upon which the Christian-conservative and neoliberal proposal of bolsonarism is founded. This proposal seeks to prohibit overarching themes around HRE. Based on this analysis, we have concluded that the de-institutionalization of HRE in Brazil has impaired the construction and dissemination of practices and policies geared towards affirming the concept of differences and diversity within various levels of education.
EV Bike
Authors: Shelar Saish , Chikane Prasad , Jadhav Aditya , Warekar Shubham , Chavan Shreya
Published: July 2023

Abstract: The E-bike is trial for converting a machine powered vehicle to an electrically powered vehicle. In this case, a bike is considered. It focuses on converting a readily available machine powered moped in the request and also streaking the machine drive and introducing an electric drive for propulsion. The new electric drive comprises of BLDC motor, battery pack, ECM. The body design and frame will remain same as the manufacturer has handed. The design and implementation of electric drive is the purpose. The purpose of E-Bike is to introduce an electric and affordable interpretation of bike which has no adverse effect on nature and doesn't use any carbon- grounded energy. The ideal is to achieve same specification as those are observed in machine driven vehicle.
Optimization of Biocompatible Ceramics for Cutting Edge Medical Equipments
Authors: M Surya Kumar
Published: July 2023

Abstract: The search for a ceramic material with the ideal composition that is completely biocompatible is of paramount importance in the field of medical applications. Achieving a perfect balance between mechanical properties and biocompatibility is essential for successful integration with living tissues and long-term implant success. In this study, we present the use of DAK TL PROBE machine to analyze the composition of each developed ceramic mold. The DAK TL PROBE machine offers a nondestructive and precise method to measure thermoluminescence (TL) signals emitted by the ceramic samples, providing valuable insights into their radiological properties and overall biocompatibility. Through this analysis, we gain a deeper understanding of the ceramics' radiation responses, allowing us to identify the most biocompatible composition for potential medical applications. This research contributes to the advancement of tailored ceramics that can be effectively utilized in diverse medical scenarios, offering improved patient outcomes and enhancing the overall field of medical materials.
Comparative Study on Seismic Analysis of Multistorey Building Using STAD Pro - A Review
Authors: Raut Shruti Diliprao , Sapate Prof. Vishal
Published: July 2023

Abstract: This literature review provides a comprehensive analysis of the behavior of buildings with concave corners in earthquake-prone areas. The study emphasizes the impact of irregularities in building planning, particularly in concave corners, on the structural performance during seismic events. Findings from various research studies highlight the necessity for detailed and comprehensive analyses, including both linear and non-linear dynamic analyses, to accurately understand the behavior and response of such structures. The research underscores the significance of regular building configuration to enhance earthquake resilience, especially in regions susceptible to seismic activity. Buildings with concave corners are found to be more vulnerable to earthquake damage compared to structures with regular configurations. Additionally, larger structures and longer overhangs are shown to result in increased stress and pressure on the reentrant corner region. Overall, the literature review emphasizes the importance of further research in the field of concave corner irregularities to develop effective seismic design and mitigation strategies. A deeper understanding of the behavior and response of buildings with concave corners will contribute to the development of safer and more resilient structures in earthquake-prone areas. Comprehensive and advanced analyses are recommended to accurately assess the performance of such buildings and to establish guidelines for their proper design and construction.