bluuebunny/crossref_metadata_2025 huggingface dataset:
Avaliação do Potencial Cardiotóxico do Vp-16 Através de um Modelo Experimental Utilizando Ratas Albinas: Discussão de Achados Anátomo-Patológicos
Authors: Schvvartsmann Gilberto , Silva Carmem Lúcia Oliveira da , Teixeira Lucas P. , Rangel Luiza , Gurski Richard R. , Segal Fábio , Coutinho Ligia B. , Marques Maria
Published: August 2023

A existência de relatos ocasionais de cardiotoxicidade pelo VP-16 motivou os autores a realizarem este estudo. Para tal, um modelo experimental utilizando dois grupos de ratas Albinas (grupo A e grupo B) foi idealizado. Os animais do grupo A foram divididos em sub-grupos de 10 (G1, G2, G3, G4 e G5), sendo tratados com VP-16-213 5mg/kg de peso por via intrapetorineal em ciclos semanais pelo prazo de oito ciclos. O grupo B recebeu solução de cloreto de sódio isotônico (0,9%) pelo mesmo espaço de tempo. Os animais do grupo A foram sacrificados a intervalos de 14 dias, segundo a ordem dos sub-grupos tratados. Os animais do grupo B foram sacrificados ao término do experimento. A avaliação anatomopatológica dos corações de animais do grupo A não diferiu significativamente entre os sub-grupos, a despeito das doses crescentes da droga. Quando estes achados foram confrontados com os do grupo B, não foram detectadas diferenças significativas entre as amostras (P menos de 0.05). Isto permite aos autores concluir pela ausência de cardiotoxicidade pela droga, o que sugere que as descrições prévias de literatura devam decorrer de fatores não-associados ao uso de droga.
Apoio Emocional a Pacientes com Doença de Hodgkin: Notas sobre uma Experiência
Authors: Farias Sérgio Luis , Camargo Sérgio Silveira
Published: August 2023

Durante um ano, uma vez por mês, um oncologista e um psicoterapeuta se reuniram com pacientes com Doença de Hodgkin com uma dupla proposta: informar os pacientes sobre sua doença e permitir que eles expusessem livremente seus sentimentos e anseios em relação à experiência de ter um tumor maligno. Pacientes com Doença de Hodgkin foram escolhidos porque, em geral, são jovens, mais diferenciados que a média, altamente curáveis e o tratamento é difícil e pode resultar em seqüelas importantes como castração. Este artigo mostra os resultados desta troca de informações, onde o ensinar e aprender se misturaram de tal forma que acabou em uma única e mesma experiência.
Pengaruh Independensi Komite Audit Dalam Memoderasi Karakteristik CEO Terhadap Kualitas Pelaporan Keuangan
Authors: Kelly Kelly , Mardianto Mardianto
Published: August 2023

This research aims to prove the influence of audit committee independence in moderating the CEO characteristics' impact on the quality of financial reporting in companies listed on the Indonesia Stock Exchange (IDX) during the period from 2018 to 2022. The sample used in this study consists of 1945 data points obtained through purposive sampling method. The research methodology employed is a quantitative approach utilizing statistical data, employing panel regression analysis, and processed using Eviews10 software. The research results indicate that audit committee independence is capable of moderating the relationship between CEO tenure and real earnings management, resulting in a negative coefficient on financial reporting quality. However, it is unable to moderate the relationship between CEO expertise and CEO ownership.
МЕТОДИ ПІДВИЩЕННЯ ПРОДУКТИВНОСТІ ПРОГРЕСИВНОГО ВЕБЗАСТОСУНКУ БІБЛІОТЕКИ НА ОСНОВІ МОДЕЛІ RAIL
Authors: БОЛЮБАШ Надія , ОЛІЙНИК Михайло
Published: August 2023

У статті розглянуто напрями цифрової трансформації бібліотечної сфери та обгрунтовано підходи, спрямовані на оптимізацію продуктивності електронних бібліотек. Метою статті є дослідження методів підвищення продуктивності прогресивного вебзастосунку бібліотеки у процесі його розробки з використанням орієнтованої на користувача моделі оптимізації продуктивності RAIL. Методи дослідження. Використано загальнонаукові методи аналізу та синтезу, методи розробки прогресивних вебзастосунків та методи оптимізації їх продуктивності, що базуються на оцінці архітектурних рішень з точки зору їх впливу на швидкість роботи застосунку. Наукова новизна дослідження полягає у виявленні в умовах сучасної цифрової трансформації бібліотечної сфери методів підвищення продуктивності вебзастосунку бібліотеки, адаптованого до роботи на різних апаратних та програмних платформах – прогресивного вебзастосунку, який поєднує у собі властивості вебзастосунку та нативного застосунку. Висновки. Використання сучасних цифрових систем обробки інформації вимагає перегляду підходів до вибору архітектур вебзастосунків, які бібліотеки використовують як платформи для взаємодії з читачами, та до визначення їх продуктивності. Для забезпечення кросплатформеності та можливості роботи із бібліотечними ресурсами у режимі offline виявлено доцільність розробки вебзастосунку бібліотеки з використанням тезнології PWA, архітектура якого включає маніфест застосунку, Service Workers та Application Shell. Дослідження методів підвищення продуктивності прогресивного вебзастосунку бібліотеки дозволило визначити стратегію застосуваня у процесі його розробки методів оптимізації продуктивності відповідно до вимог моделі RAIL: стиснення розміру зображень та задання їх розмірів явним способом через атрибути; зменшення JavaScript коду – оптимізуючи функції та розділивши тривалі завдання на завдання з тривалістю не більшою за 50 мс шляхом впровадження асинхронного коду; реалізація плавної анімації за допомогою CSS5 із обробкою кожного кадру до 10 мс; групування завдань, які виконуються у фоновому режимі, у блоки, не більші за 50 мс.
“Como é trabalhar aí?”: os afetos que circulam nas empresas produtoras de mensagens
Authors: Picchiai Daniela de Queiroz , Santos Rogério da Costa
Published: August 2023

Este artigo analisa as opiniões e impressões das relações de trabalho entre profissionais de agências e produtoras de mensagens, tendo como fonte de pesquisa a planilha “Como é trabalhar aí?” Trata-se de uma planilha disponibilizada nas redes sociais para recolher impressões de trabalho dos profissionais das áreas de comunicação, marketing, publicidade e propaganda. Os dados considerados na planilha foram aqueles inseridos entre os anos de 2016 e 2020. O objetivo da presente pesquisa foi extrair dos depoimentos dos profissionais suas percepções das relações de trabalho e os sentimentos mobilizados nos ambientes produtores de comunicação, buscando compreender, a partir daí, quais afetos circulam nesses locais. O artigo levanta questões pouco abordadas nesse campo de trabalho, uma vez que busca observar a comunicação a partir da experiência emocional dos profissionais que estão envolvidos com sua produção. Para contribuir para tal entendimento, o artigo vale-se de alguns autores como Baruch Spinoza, Maurizio Lazzarato, Franco Berardi e Judith Butler.
ЦИФРОВІ РЕПУТАЦІЙНІ ПЕРСПЕКТИВИ УКРАЇНИ ЯК ФАКТОР ЄВРОІНТЕГРАЦІЇ В УМОВАХ ІННОВАЦІЙНОЇ ЕКОНОМІКИ
Authors: Мельник Леонід , Карінцева Олександра , Калініченко Людмила , Розгон Юлія , Чорток Михайло
Published: August 2023

У статті обговорюється важливість конкурентоспроможності України в процесі її євроінтеграції як фактору переходу до інноваційної економіки. Особлива увага приділяється ролі інформаційних технологій (ІТ) у сучасному світі, їх впливу на розвиток економіки та позицію країни в глобальному контексті. Розвиток ІТ-освіти є важливим фактором підвищення конкурентоспроможності країни. Якісна підготовка ІТ-фахівців сприяє залученню та розвитку високотехнологічних компаній, інноваційного бізнесу та стимулює перехід до інноваційної економіки. Розвиток української молоді в ІТ-секторі є перспективним, але вимагає постійного вдосконалення та фокусу на розвитку ключових навичок, таких як англійська мова, практичні вміння роботи з новітніми технологіями та здатність безперервно навчатися та адаптуватися до змін у галузі. Розвиток якісної вищої освіти, наукових досліджень і інфраструктури в галузі ІТ є критичними для успішної євроінтеграції країни. Високорейтингові університети та наукові інститути в сфері ІТ привертають талановитих фахівців і забезпечують підготовку висококваліфікованих кадрів. Компетентність ІТ-фахівців в створенні нових технологій та інноваційних продуктів є ключовим фактором для інноваційного розвитку країни. Сильна ІТ-індустрія має багато переваг, таких як створення нових робочих місць, залучення іноземних інвестицій і сприяння економічному зростанню. Це також сприяє розвитку інноваційного середовища, що в свою чергу забезпечує стійку інтеграцію в європейський економічний простір. Для досягнення цих цілей важливо постійно вдосконалювати освітні програми, створювати сприятливі умови для бізнесу та інновацій, інвестувати у розвиток ІТ-інфраструктури і встановлювати стратегічні партнерства.
БІОЕКОНОМІКА: ПЕРСПЕКТИВИ РОЗВИТКУ АГРОПРОМИСЛОВОГО КОМПЛЕКСУ УКРАЇНИ ДЛЯ ПОДОЛАННЯ ПРОДОВОЛЬЧОЇ КРИЗИ
Authors: Будякова О.Ю. , Дьяконов І.О.
Published: August 2023

Людство стикається з глобальними проблемами, включаючи зміну клімату, продовольчу кризу та ін. Біоекономіка готова відігравати центральну роль у вирішенні цих проблем. У продовольчому секторі стратегія «Від лану до столу» використовує сталі та екологічно чисті практики, які передбачають значне зменшення використання хімічних пестицидів, добрив та антибіотиків. Метою цієї стратегії є зменшення впливу пестицидів на продукти харчування на навколишнє середовище. Зараз, коли Україна перебуває у стані війни, зростає дефіцит продовольства та зростає занепокоєння щодо продовольчої безпеки в усьому світі. Війна, яка триває в Україні, загострила проблему продовольчого забезпечення не лише в ЄС, але й в інших регіонах. Крім того, величезна кількість забруднення ґрунту, води та повітря, спричинена несталим виробництвом продуктів харчування, призводить до втрати біорізноманіття та сприяє зміні клімату. На інтенсифікацію втрати біорізноманіття в ЄС значною мірою впливають інтенсифікація сільського господарства через високі обсяги застосування добрив і пестицидів. Для підтримки довгострокової сталості як природи, так і сільського господарства, стратегія ЄС з біорізноманіття до 2030 року працює в тандемі зі стратегією «Від лану до столу», які передбачають вжити заходів для скорочення на 50% загального використання хімічних пестицидів і ризиків, пов'язаних з ними, до 2030 року.
СУЧАСНІ ТЕНДЕНЦІЇ РОЗВИТКУ ДЕРЖАВНИХ БАНКІВ В УКРАЇНІ
Authors: Матвійчук Н.М.
Published: August 2023

Метою дослідження є визначення основних тенденцій розвитку банків з державною участю в 2020-2023 рр. З’ясовано, що розвинута мережа відділень, приналежність до об’єктів критичної інфраструктури, підтримка з боку держави та довіра населення зумовлюють особливу важливість державних банків для забезпечення стабільності економіки та національної безпеки держави у воєнний та післявоєнний періоди. Проаналізовано місце банків з державним капіталом в банківській системі за активами, кредитним та депозитним портфелем. Здійснено оцінку фінансових результатів діяльності державних банків упродовж 2020-2023 рр., обгрунтовано причини прибутковості та збитковості в різні періоди. Виокремлено основні проблеми функціонування державних банків: висока частка NPL, зменшення кількості діючих відділень, нижчі показники ефективності у порівнянні з приватними та іноземними банками, надто висока частка держави у банківському капіталі тощо.
Effect of implementation of irrigation on raptor and corvid populations in a Mediterranean agrosystem
Authors: Villanúa D. , Cabodevilla X. , Ardaiz J. , Lizarraga A. , Zufiaurre A.
Published: August 2023

We analyzed changes in the composition of the community of birds of prey and corvids in a rainfed agrosystem after the transformation of 37.2 % of the sampled area into irrigated land between 2005 and 2020. We sampled 57 transects (372 km per year) and fitted generalized linear mixed models (GLMM) to study changes in species occurrence. Our results showed that specific richness and the Shannon index did not vary significantly between rainfed and irrigated transects, but there was a certain positive trend when comparing the years 2005 and 2020. Regarding the differences detected for each species, the occurrence of Montagu’s harrier Circus pygargus, hen harrier Circus cyaneus, Eurasian short-toed eagle Circaetus gallicus, griffon vulture Gyps fulvus and carrion crow Corvus corone was significantly lower in irrigated land than in rainfed land, while magpie Pica pica, Western marsh harrier Circus aeruginosus, common kestrel Falco tinnunculus and black kite Milvus migrans showed a significantly higher occurrence in the irrigated transects. In addition, our findings confirm a significant decrease in occurrence between 2005 and 2020 both in rainfed and irrigated areas for Montagu’s harrier, hen harrier and magpie, while Western marsh harrier, golden eagle Aquila chrysaetos, common buzzard Buteo buteo, red kite Milvus milvus, griffon vulture Gyps fulvus, red-billed chough Pyrrhocorax pyrrhocorax and Western jackdaw Coloeus monedula were detected significantly more frequently in 2020 than in 2005. These results suggest that assessment of the impact of a new irrigation system should focus on the most characteristic species of rainfed agrosystems because the apparently positive effect on other species, equally protected but more generalist, may mask the real effect on conservation.
Analisis Isu Islamophobia Di Jerman: Studi Kasus Muhammadiyah Sebagai Organisasi Gerakan Islam Modernis Indonesia
Authors: Agustari Agustari , Ulinnuha Roma
Published: August 2023

The case of Islamophobia is one of the cases that is often reported in the German media, which is closely related to the failure of multiculturalism politics which has an impact on the emergence of a negative stigma against Islam. Being a Western country with the largest Muslim population in Europe with a total of approximately 5.3 to 5.6 million people, based on data from the Federal Office for Migration and Refugees (BAMF) in 2021, the German government's policy towards Muslim immigrants is very exclusive and limited. Despite the many negative stigmas, Islam has been transformed into one of the major entities whose existence is considered. Muhammadiyah is one of the Islamic organizations in Indonesia that has diasporaized the "Modernist Islam" missionary movement in Germany. Through the modernist Islamic diaspora, Muhammadiyah seeks to explore the issue of Islamophobia by developing a da'wah movement through real programs to raise the positive image of Islam in German society. The method used in this research is a descriptive qualitative approach, which involves conducting a literature review, where all the data used in this study uses secondary data, which includes books, theses, theses, articles, journals, and various news related to this research. The results of this study illustrate that the modernist Muhammadiyah Islamic diaspora in Germany has had quite a positive impact in efforts to minimize the negative stigma of Islamophobia in Germany.
Compulsive Buying-Shopping Disorder Associated with Recurrent Depressive Disorder: A Case Report
Authors: Puiu Maria Gabriela , Dionisie Vlad , Manea Mihnea Costin
Published: August 2023

Compulsive buying – shopping disorder remains an incompletely defined and controversial pathology to our days. However, in the last years, progress has been made in establishing diagnostic criteria and developing new assessment instruments. In the absence of inclusion in the main diagnostic systems and without a largely accepted diagnostic criteria, compulsive buying shopping disorder is rarely recognized and diagnosed in clinical practice. In this context, we present the case of a 61-year-old female with compulsive buying–shopping disorder associated with recurrent depressive disorder. Our patient's symptoms met almost completely the set of criteria proposed by Müller et al. Even though the diagnosis of this disorder in our patient was not followed by a successful pharmacological intervention, we believe it brought a better understanding of the case, which may lead to a more successful approach in the future.
Cálculo de radios geocéntricos por grados de latitud
Authors: Tovar Cabañas Rodrigo , Villanueva Hernández Hipólito , Vazquez Espinosa Shany Arely
Published: August 2023

El objetivo del presente ejercicio es hacer frente a la pérdida de cognición y por ende pericia para realizar transformaciones geométricas de modelos esféricos a modelos elipsoidales dentro de la enseñanza de la geografía a nivel licenciatura. Se postula que los sistemas satelitales de navegación global basados en elipsoides de referencia aún son concebidos como sistemas esféricos por muchos alumnos debido a la ausencia de ejemplos prácticos que ayuden a su comprensión pedagógica. Para cubrir dicha laguna en este trabajo se calcularon la excentricidad, la latitud geocéntrica y el radio geocéntrico de los 90 principales paralelos del elipsoide de referencia WGS84. Metodológicamente se trabajó sobre un universo de estudio superior a los 324 mil segundos de latitud. De los cuales sólo se muestran los 90 casos principales. Con un criterio analógico se determinó el radio geocéntrico para los puertos de Salina Cruz, Oaxaca, Tampico, Tamaulipas y Ensenada, Baja California. Como resultados se exhibe que la distancia al centro de la Tierra entre Salina Cruz, y Ensenada hay una diferencia de 4 kilómetros.
Sobre justificaciones en matemática: cuantificadores, implicaciones y equivalencias
Authors: Carena Marilina
Published: August 2023

Este trabajo tiene como fin analizar algunas justificaciones acerca de los valores de verdad de proposiciones matematicas básicas que contienen cuantificadores o implicaciones. En particular, se hace enfasis en las formas incorrectas de hacerlo, puesto qué muchas de ellas persisten aun en estudiantes avanzados de carreras de grado. Esto se abordará, principalmente, desde lo coloquial para ser aplicado luego en ejemplos matemáticos básicos
Analisis Korelasi antara Kecemasan dan Kejadian Preeklamsia pada Ibu Hamil
Authors: Saddam Muhammad , Saharuddin Saharuddin , Yunus Purnamaniswaty , Fitriani Rini , Galib M.
Published: August 2023

Latar belakang: Preeklamsia masih menjadi tiga besar penyebab kematian ibu dalam bidang obstetri. Preeklamsia menduduki peringkat dua sebagai penyebab kematian langsung pada ibu hamil dan mengalami peningkatan setiap tahunnya. Kecemasan merupakan unsur kejiwaan yang menggambarkan perasaan, keadaan emosional yang dimiliki oleh seseorang pada saat menghadapi kenyataan atau kejadian dalam hidupnya. Hal ini meningkatkan eksresi hormon vasoaktif atau neuroendokrin lainnya yang dapat meningkatkan risiko hipertensi dan juga memicu perubahan pembuluh darah sehingga menyebabkan terjadinya preeklamsia.

Metode: Metode yang digunakan dalam penelitian ini yaitu analitik korelatif, dengan pendekatan cross sectional sebanyak 93 responden (1:2) yang dikumpulkan secara purposive sampling.

Hasil: Hasil uji statistik diperoleh P-value ≤ 0,05 dan PR = 4,646 (95% CI 1,824-7,288).

Kesimpulan: Pada penelitian ini terdapat hubungan yang signifikan antara kecemasan dengan kejadian preeklamsia di Rumah Sakit Khusus Daerah Ibu dan Anak Pertiwi Makassar.
Tatalaksana Syok Sepsis Akibat Community Acquired Pneumonia dengan Penyulit Acute Kidney Injury
Authors: Bachrun Tamsil , Muchtar Faisal , Salam Syamsul Hilal , Palinrungi Ari Santri
Published: August 2023

Latar Belakang: Sepsis merupakan disfungsi organ yang mengancam jiwa akibat disregulasi respons tubuh terhadap infeksi. Pneumonia  merupakan  penyebab  utama  lebih  dari  50%  angka  kejadian  sepsis  pada  pasien  di Intensive  Care  Unit (ICU).

Isi: Laporan kasus ini membahas pasien laki-laki usia 36 tahun dengan penurunan kesadaran dan gelisah, sesak napas disertai tidak ada produksi urin sejak 1 hari sebelumnya. Dari pemeriksaan fisis, laboratorium dan pemeriksaan penunjang pasien didiagnosis dengan syok sepsis yang disebabkan penumonia komunitas, edema paru karena paru uremik dan cedera ginjal akut pada penyakit ginjal kronik akibat nefropati diabetik.Pada pasien dilakukan pemberian ventilasi mekanik, vasopressor, pemasangan monitor invasif, sedasi dan analgetik, antibiotik empirik spektrum luas dan dilakukan continuous renal replacement therapy (CRRT) selama 4 hari.

Kesimpulan: Telah dilaporkan sebuah kasus keberhasilan dan keamanan penerapan CRRT pada pasien pneumoni komunitas dengan penyulit syok sepsis dan cedera ginjal akut di ICU. Terapi ini dapat dipertimbangkan sebagai salah satu pilihan pada pasien dengan masalah yang sama.
Penatalaksanaan Drowning: Review Article
Authors: Rusydi Muhammad Ammar , Farehan A Anggia Viona , Ashlihan Baiq Rulia , Olivia Fadila , Febrian Haldy Dwi
Published: August 2023

Latar belakang: Drowning atau tenggelam didefinisikan sebagai masuknya cairan yang cukup banyak ke dalam saluran nafas atau paru-paru. Dalam kasus tenggelam, terendamnya seluruh tubuh dalam cairan tidak diperlukan. Yang diperlukan adalah adanya cukup cairan yang menutupi lubang hidung dan mulut sehingga kasus tenggelam tidak hanya terbatas pada perairan yang dalam seperti laut, sungai, danau, atau kolam renang, tetapi mungkin pula terbenam dalam kubangan atau selokan di mana hanya bagian muka yang berada di bawah permukaan air.

Isi: Ketika seseorang tenggelam, air yang masuk ke mulut bisa saja tertelan atau dimuntahkan. Ketika dorongan inspirasi terlalu tinggi untuk dilawan, air dapat tertelan ke saluran udara dan batuk terjadi sebagai respons refleks. Cairan yang diaspirasi dapat menyebabkan washout dan disfungsi surfaktan, peningkatan permeabilitas kapiler, kolaps alveolar, dan ketidaksesuaian rasio ventilasi- perfusi. Hal ini dapat menyebabkan keluhan pernapasan ringan hingga hingga edema paru non- kardiogenik fulminan, dengan gambaran klinis yang mirip dengan sindrom gangguan pernapasan akut atau dewasa (ARDS).

Kesimpulan: Near drowning atau keadaan hampir tenggelam merupakan suatu kondisi seseorang hampir mati karena tidak bisa bernapas atau tercekik di bawah air. Prinsip utama penatalaksanaan dalam kasus drowning adalah mempertahankan oksigenasi yang adekuat, mencegah aspirasi dari lambung, dan menstabilkan suhu tubuh. Berdasarkan hal ini, tatalaksana kegawatdaruratan yang dapat dilakukan yaitu berupa resusitasi jantung paru (RJP). Manajemen jalan napas yang baik menjadi aspek kunci dalam mendapatkan prognosis yang baik. Pasien near-drowning yang mengalami hipotermia ditatalaksana dengan prinsip rewarming baik aktif mau pun pasif.
Analisis Penggunaan Antibiotik Pasien Demam Tifoid dengan Komplikasi dan Tanpa Komplikasi yang Dirawat di Rumah Sakit
Authors: Idrus Hasta Handayani , Utami Nurfika , Rahmawati Rahmawati , Daeng Kanang Indah Lestari , Musa Inna Mutmainnah , Rasfayanah Rasfayanah
Published: August 2023

Latar belakang: Demam tifoid disebabkan oleh bakteri Salmonella enterica reservoir typhi, juga dikenal sebagai salmonella typhi (S. typhi). Tujuan dari penelitian ini untuk mengetahui bagaimana efek penggunaan antibiotik pada pasien demam tifoid yang komplikasi dan tanpa komplikasi.

Metode: Jenis Penelitian ini adalah deskriptif kualitatif, menggunakan  pendekatan Cross Sectional Study. Desain Cross Sectional  Study digunakan karena proses pengambilan data dilakukan dengan menggunakan data yang telah ada sebelumnya di RSUD I Lagaligo Luwu Timur pada tahun 2021. Kriteria inklusi semua pasien yang terdiagnosis demam tifoid dengan dan tanpa komplikasi dengan analisis data menggunakan SPSS.

Hasil: Karakteristik penderita demam tifoid dengan komplikasi dan tanpa komplikasi berdasarkan terapi perawatan, diperoleh terapi perawatan paling banyak menggunakan ceftriaxon pada penderita dengan komplikasi sebanyak 21 orang (26,3%) dan tanpa komplikasi 22 orang (27,5%).

Kesimpulan: Terapi kausatif yang paling banyak digunakan pada penderita demam tifoid adalah penggunaan antibiotik golongan sefalosporin yaitu ceftriaxone dengan lama perawatan 1-14 hari.
Karakteristik Pasien Sirosis Hepatis
Authors: Amalia Mutiara , Hidayati Prema Hapsari , Eka Yanti Andi Kartini , Vitayani Sri , Gayatri Sri Wahyuni
Published: August 2023

Latar belakang:. Berdasarkan data dari World Health Organization (WHO) pada tahun 2016 sekitar 51,1% laki laki dan 27,1% perempuan dari 100.000 populasi meninggal akibat sirosis hepatis. Di Indonesia data mengenai sirosis hepatis masih kurang oleh karena itu diperlukan penelitian mengenai karakteristik sirosis hepatis. Tujuan : Penelitian ini bertujuan untuk mengetahui karakteristik pasien sirosis hepatis di Rumah Sakit Ibnu Sina Makassar Tahun 2018-2021.

 Metode: Desain penelitian yang digunakan yaitu deksriptif observasional. dengan menggunakan data sekunder dari rekam medik pasien sirosis hepatis di Rumah Sakit Ibnu Sina Makassar tahun 2018-2021. Hasil: Pada penelitian ini didapatkan usia terbanyak pada kelompok 51-60 tahun (45,5%) dan sebanyak 36 pasien (65,5%) berjenis kelamin laki laki. Dengan tingkat Pendidikan terakhir setara SMP/Sederajat (36,4%), dan berstatus tidak bekerja (41,8%). Penyebab sirosis terbanyak adalah hepatitis B (54,5%), dengan komplikasi terbanyak adalah asites (38,2%). Sekitar 29 pasien (52,7%) memiliki klasifikasi child pugh B dan sebagian besar sirosis hepatis dekompensata (46%).

Kesimpulan:. Pasien sirosis hepatis di RS. Ibnu Sina Makassar paling banyak ditemukan pada kelompok usia 51-60 tahun, laki laki, pendidikan terakhir SMP/Sederajat, dan tidak bekerja. Penyebab tersering hepatitis B dengan komplikasi asites, klasifikasi child pugh B, dan merupakan sirosis hepatis dekompensata.
EDUCATION FROM THE SYSTEMIC POINT OF VIEW: THE CONTEXT OF (NON) - CONSTANT TRANSFORMATIONS
Authors: Lamanauskas Vincentas
Published: August 2023

It is generally undeniable that education is a complicated and complex system. Moreover, it is an integrated and integral system of teaching and learning at different levels and in different contexts. In the public academic educational discourse, the need to search for modern teaching and learning methods is constantly expressed so that educational institutions can better respond to the changing educational needs of learners and society. However, there is no unequivocal answer to what is “modern”. Complex knowledge of education systems (and education as a system) guarantees effective educational changes in them. If we are talking about scientific knowledge of educational phenomena, it cannot be otherwise. Based on this point of view, most educational phenomena and processes can be called systems.
Bioactive Secondary Metabolites to Combat Diabetic Complications: Evidenced from in Silico Study
Authors: Hasnat Hasin , Shompa Suriya Akter , Richi Fahmida Tasnim , Islam Md Mirazul , Suman Mehedi Hasan , Ahmed Nazim Uddin , Ashrafi Sania , Zaman Anika , Saha Tanoy , Islam Md Ashraful , Alam Safaet
Published: August 2023

Diabetes mellitus (DM) is a condition characterized by excessive blood sugar levels, which have recently reached the level of a pandemic. There are various side effects of each drug to treat this condition. Molecular docking is a modern concept for computer-aided drug designing. Using this technique several potential antidiabetic phytocompounds are evaluated against three target receptors including GLUT-3, PPARγ and α-amylase related to DM. These compounds' ADMET and drug-likeliness characteristics have also been assessed to determine potential drug candidacy. Most of the compounds exhibited magnificent binding affinity against these targets, especially compounds 30 and 27 have shown great affinity against GLUT-3 with values of -11.2 and -10.2 Kcal/mol respectively. Where compound 37 has the highest binding affinity (-9.1 Kcal/mol) against PPARγ. Also, with values of -11.6 and -10.8 Kcal/mol respectively compounds 38 and 12 notably bind with α-amylase. Moreover, all of these compounds have magnificent results on ADMET and drug-likeliness studies, in particular, compound 29 has shown high affinity against all of these receptors, explored 0.55% bioavailability score, no toxicity and high absorptivity. Although these compounds have undergone a preliminary drug discovery study, more research must be done to determine their precise mechanism of action against DM.
Bangladesh Pharmaceutical Journal 26(2): 167-184, 2023 (July)
The Development of Critical Thinking Skills Assessment Instrument Based on Nearpod in Junior High School Science Learning
Authors: Maghfiroh Rohmatul , Wahyuni Sri , Ridlo Zainur Rasyid
Published: August 2023

Critical thinking skills are one of the skills needed in the 21st century, where to be able to assess critical thinking skills, assessment instruments are required. The aim of the research is development critical thinking skills instrument based on nearpod in junior high school science learning that meets valid, reliable, difficult, and practical criteria as well as critical thinking skills analysis. This research is a Research and Development research (R&D) with the GLAI model. The validity of the product is assessed by three validators consisting of one lecturer and two science teachers. Testing of assessment instruments was carried out on 125 grade VII students. The average product validity assessment of the three validators was 81.70% with valid criteria.  Based on the field tests conducted, it is known that 10 items are valid with a reliability score of 0.602. At the difficulty level, the product has 1 easy item, 8 sufficient items, and 1 difficult item. In practicality, 97.66% was obtained with very practical criteria. In the analysis of critical thinking skills,  the results of interpretation were obtained by 28.68% (very low), analysis by 31.20% (very low), inference by 43.44% (very low), and explanation by 47.80  % (low).  So it is known that the critical thinking skills instrument based on nearpod in junior high school science learning was developed was valid, reliable, difficult levels, practical, and effective in measuring critical thinking skills.
Analysis of High School Students' Mathematical Problem-Solving Ability Based on Mathematics Anxiety and Gender
Authors: Putri Cinthia Venita , Miatun Asih
Published: August 2023

The purpose of this study was to analyze the mathematical problem-solving abilities (KPMM) of high school students based on math anxiety and gender. The methodology use in this study is qualitative, specifically using a case study approach. The study utilized students from SMA Negeri 31 Tangerang Regency, who were in the 11th grade and studying arithmetic sequences and series. The research subjects were six people, two from each category of math anxiety, chosen through purposive sampling using Winstep and based on an analysis of the person map table. The instruments used were a six-item math problem-solving ability test and a 27-item math anxiety questionnaire that had been validated by expert lecturers and mathematics teachers and was therefore feasible to use. Reduction, categorization, synthesis, and a conclusion were all used to analyze the data in this study. Based to the study's results, gender did not have a significant impact on students' mathematical problem-solving abilities. However, what distinguished them was the category of math anxiety. Male and female students with high levels of anxiety in maths were only able to fulfil one KPMM indicators, but those with moderate and low levels of anxiety were able to fulfil three.
The Effect of The GeoGebra-Based Project Based Learning (PjBL) Model on the Creative Thinking Ability of Junior High School Students
Authors: Wiyanti Adella Irma , Hadi Windia
Published: August 2023

The PjBL model provides opportunities for individuals to work freely, which fosters genuine individual creativity and the ability to think creatively using media such as GeoGebra. GeoGebra media is able to visualize in a realistic manner, allowing individuals to understand it effectively. This study aims to determine the effect of the GeoGebra-based Project Based Learning (PjBL) model on the creative thinking skills of junior high school students. This is quantitative research using a quasi-experimental approach with a posttest-only control design. The sample of this study are 70 seventh-grade students, particularly 35 students for the ability to think creatively in the GeoGebra-based PjBL model and 35 for the Non-GeoGebra-based PjBL model. The instrument employed consisted of a 5-question essay test on the ability to think creatively, with earlier phases of the validation of expert and from the eighth-grade students in various schools. The results of data analysis using the Mann Whitey Non-Parametric test were obtained at 0.118 (P Value > 0.05 significant level). According to the findings of the analysis, the GeoGebra-based PjBL model does not significantly convert the creative thinking abilities of the students, despite it gives an impact of the influence of junior high school students' abilities.
Designing Interactive Learning Application Using Markerless Augmented Reality on Evolution of Atomic Theory Material
Authors: Fanmita Zhafira , Guspatni Guspatni
Published: August 2023

To increase student understanding and enrich the learning experience, research was conducted with the aim of designing a interactive learning application using markerless augmented reality as an interesting solution. This is because learning applications use augmented reality in evolution of atomic theory material into a form of education that combines innovative technology with personalized learning, so that it can help create a generation that is technologically skilled and ready to face future challenges. This research includes educational design research using Plomp development model, including preliminary research stage by doing the needs and context analysis, literature review, and theoretical framework and prototyping stage, including initial plan and self evaluation. For the results based on preliminary research data and the prototyping phase, it can be concluded that the design of learning applications using Plomp development model which produces prototype II that has been successfully run as expected according to the design based on the results of analysis in preliminary research. This application prototype is hoped to be continued to produce learning applications that can be used in schools to support chemistry learning.
The Effect of Couple Card Media on Elementary School Students’ Science Learning Outcomes in Class IV MIN 8 Medan City
Authors: Rahmawati Indi , Safran Safran
Published: August 2023

The reason for conducting research is based on several problems in the form of teaching activities whose center is still on the teacher (teacher centered), on the other hand the students' learning outcomes are still low and the teaching process has not been able to fully improve student outcomes in their learning. The aim of the research is to find out the effect of Couple Card media on Elementary School Students’ Science Learning Outcomes in Class IV MIN 8 Medan City. The research method used was in the form of an experiment through a quasi-experimental design in the form of a nonequivalent control group, which acted as research subjects, consisting of 40 students of class IV. In analyzing the data, the researcher conducted a normality test accompanied by the Wilcoxon test due to not normally data distribution. Based on the Wilcoxon signed rank results, it can be seen that Asymp.Sig.(2-tailed) has a value of 0.001. Because the value of 0.000 is smaller than 0.05 (0.000 < 0.05) it is understood that there are differences in learning outcomes with these differences being significant both in the pretest and post-test when learning is not carried out using couple card media. Through the use of media in the form of couple cards it is known that there is an influence on the learning outcomes passed by students so that it was concluded that the media in the form of couple cards provided an increase in student results in their learning.
Correlation of Self Efficacy with Entrepreneurial Attitudes of Science Teacher Candidates
Authors: Wazni M. Khairul , Muliadi Agus
Published: August 2023

This study aims to determine the correlation of self-efficacy with student attitudes in the field of entrepreneurship. This study is a descriptive exploratory study with 35 biology education students as subjects. The research instrument used was a closed questionnaire with degraded answers according to a Likert scale that had been validated by experts and declared valid. Analysis of the research data used is descriptive statistics and inferential statistics with a product moment (rxy) correlation test at a significance level of 5%. The study results show that (1) students' perceptions about self-efficacy has an average score of 3.12 in the Good category and an entrepreneurial attitude of 3.06 in the Good category; (2) there is a significant relationship between self-efficacy and student attitudes in the field of entrepreneurship with a significance value of 0.000 which is smaller than the alpha testing value of 0.05 (<0.05); (3) the value of the correlation coefficient is 0.803, which means that the relationship is very strong between self-efficacy and student attitudes in the field of entrepreneurship.
A Research on Burn Relief Antibacterial Ointment
Authors: Singh Supriya , Chouhan Ashwin Singh , Suthar Deepak , Panwar Susheela
Published: August 2023

Burning is a mishap that can occur anytime with anyone. Burns that are superficial or partial-thickness often recover within two weeks, excluding complications such infections or chronic conditions. Topical creams are frequently used to treat superficial and partial thickness burn in order to maintain a moist wound environment, reduce pain, and stop bacterial infection. Severe burns require attention of special kind and may also end up requiring hospitalization. In this research work, we focused on preparing burn relief ointment with the help of neosporin, amoxicillin, lignocaine and petroleum jelly. Neosporin and amoxicillin act as antibacterial agents, lignocaine acts as local anesthetic agent and petroleum jelly has been used as ointment base.
Redesigning Concept of the UIN Raden Intan Lampung’s Student Dormitory
Authors: Jajuli Ahmad , Munawaroh Ai Siti , Hartabela Dadang
Published: August 2023

The existence of a dormitory in the UIN Raden Intan Lampung is one of the supporting activities for lectures. Plus, the number of students who come from outside the city of Bandar Lampung makes the dormitory a very interesting place to live. Meanwhile, the dormitory capacity is still very limited. Therefore, it is necessary to redesign so that capacity can be increased, and student activities can be accommodated. This study aims to redesign the current student dormitory. The research method is carried out by documentation at the site location, analyzing the problems and resulting the concept. The results showed that there were three main concepts in redesigning the student dormitory of UIN Raden Intan Lampung, namely: site and environmental, building user and the building itself.
Revitalization of Moderation Messages in the Madinah Charter: Religious Development Communication Studies
Authors: Al-Mujtahid Nazil Mumtaz , Sazali Hasan
Published: August 2023

This paper aims to determine the role of the Medina charter as a role model in the Indonesian context. The Medina Charter and the Constitution in force in Indonesia both have the function of regulating a heterogeneous society. However, the results of the implementation of the two are very contradictory. The rise of religious problems in Indonesia has led to the assumption that the constitution is unable to accommodate the interests of the whole society. This type of research uses qualitative methods with data collection techniques in the form of interviews and virtual observations. For secondary data used is a literature review approach by comparing various reading materials. This approach is able to provide arguments and reveal problems in a scientific and actual way. The results of the research show that the construction of messages in the Medina charter is oriented towards social and cultural values so that it creates synergy between religious communities. The message of moderation contained in the Medina charter places the principles of humanity with religion as a moral force.
IMPROVING STUDENT COMPETENCE THROUGH LEARNING MANAGEMENT OUTCOME BASED EDUCATION
Authors: Husna Khotimatul , Mundiri Akmal , Agus R Abu Hasan
Published: August 2023

The era of the industrial revolution 4.0 really needs human resources who have excellence in the fields of communication and knowledge, where higher education as a place for building student character has an important role in improving the quality and competence of students in the results-based domain. This OBE-based learning can be the main way for students to develop the competencies that each student has that they cannot express when they are students. This competence and results-based learning does not only focus on learning using methods but also in conducting field work practices. Writing this scientific paper has a very significant goal in realizing student competency in improving the quality of results-based learning. The research approach used is a qualitative approach with a case study type. In order to obtain data, researchers used observation and interview techniques. The results of the study show that the management of learning based on outcome base education in order to improve quality and competence is carried out in the form of; Internships and work practices, serving students, teaching campuses and student exchanges.
INCREASING STUDENT RESPONSIBILITY THROUGH THE APPLICATION OF NUMBERED HEAD TOGETHER BASED ON STUDENT WORKSHEET
Authors: Sitorus Monika Yosevin , Soesanto Robert Harry
Published: August 2023

Student responsibility is one of the attitudes that is expected to exist in students in carrying out learning. The attitude of responsibility will be seen in how students carry out their duties and obligations optimally the responsibility of students in learning is still a problem. In a study conducted on grade 8 students in a private school in the Tangerang area, it was found that student responsibility was low. This study uses a qualitative approach with a type of case study. The research results show that numbered head together model carries student-centered learning by applying 4 stages. The planning and numbering stage is the stage that supports the next stage. At the stage of thinking together, students have discussions in groups so that there is an increase in responsibility to be active in discussions. At this stage, students work on worksheets with focus and caution so that students’ responsibilities in doing assignments carefully also increase. In the answering stage, students will be randomly selected based on the numbers on their respective worksheets so that students are ready to be called because students are already responsible for completing the assigned tasks on time. This research is expected to provide real solutions to the problem of student responsibility.
Open Your Ears, Paris Dada! Where Is Your Music Coming From?
Authors: Dayan Peter
Published: August 2023

The historical record tells us that music of many kinds was played at Paris Dada events. There was piano music from the contemporary high art tradition; there was jazz; and there was also ‘anti-music’, later described (not entirely credibly) by its composer Georges Ribemont-Dessaignes. None of this music finds an audible echo in the Paris Dada manifestos of Tristan Tzara. Music is central to his discourse on Dada; but it is music as incarnated, out of time, by the physical musical instrument, not music as it was played in live performance and received by an audience in real time. The reason is the Dada refusal to see art as anything that can be defined, or as the communication of a message sent by a human agent. The instrument, as a physical object, cannot, in Dada, be seen through to the art or the artist beyond. This is in many ways a logically untenable position, because we never cease to believe that the music we hear is something more than the instrument on which it is played. Lies have to be told in order for Dada to occupy that untenable position. But Tzara assumes those lies, and the necessity for them; and so do I.
The Effectiveness of Settlement of Criminal Acts of Minors Through Non-Litigation Efforts at the Gorontalo District Court
Authors: Amiri Ismiaty
Published: August 2023

Abstract: This Reaserch aims at finding out  (1) to what extent the efficacy of non-litigation, especially diversion in settlement of crimes involving children, in Gorontalo district court and (2) factors hindering the non-litigation process against crimes involving children in Gorontalo district court. The research method employs a normative and ampirical approach.Finding indicate that the implementation of non-litigation in settlement of crimes involving children in Gorontalo district court is less effective. This is due to the externalities existing on the child who is referred to as a perpetrator or victim’s parent/guardian. Hence, a thorough education outreach needs to be conducted to the family and the children regarding the objectives and the benefits of the diversion. Key words : Crimes Involving children, Non-Litigation, Diversion
Effectiveness of Impeachment Against Deputy Regent of Gorontalo Regency
Authors: Lasimpala Luksiana , W. Badu Lisnawaty , M. Nggilu Novendri
Published: August 2023

The purpose of this research is to know and analyze the Legal Regulation of The Impeachment of Regional Heads and/or Deputy Heads of Regions according to The Provisions of Law No. 23 of 2014 on Local Government and the effectiveness of impeachment against the deputy Regent of Gorontalo Regency. The type of research used by researchers in the preparation of this study is to use normative research types that are supported by the existence of field data (empirical) using   2 (two) approaches, namely the Legislative And Case Approach.  The results of this study show that the effectiveness of impeachment against the deputy Regent of the Gorontalo Regency is influenced by 3 (three)factors that affect the effectiveness of dismissal against the deputy Regent of the Gorontalo Regency, namely: the legal factor.   alone, where there is no normative framework that regulates the law of dismissal events in the head of the region, second, law enforcement factors, namely regarding the competence of judges in the break the case and the unclear involvement of legal counsel (advocate), third, the legal culture factor characterized by the disobedience of the Ministry of Home Affairs to the deadline which has been made imitatively in Law 23 of 2014 concerning Local Government.
Effectiveness Of Traffic Operations On Increasing Helmet Use In Gorontalo City
Authors: Nusi Ayis
Published: August 2023

This study aims to determine the effectiveness of the implementation of traffic operations to increase compliance with helmet use for motorcyclists in the city of Gorontalo. The type of research used in this research is empirical legal research. This research is located at the Gorontalo City Police Traffic Unit. The data used in this study were obtained using observation and interview techniques. The results of this study indicate that there are still many violations of the use of helmets so that the implementation of traffic operations to increase compliance with using helmets for motorbike riders in the city of Gorontalo has not been effective, other efforts need to be made by the Satlantas Polres Gorontalo City, namely: Police friends of children, school security patrols , Provide socialization and traffic education, Install billboards containing the rules and the importance of helmets, Cooperate with agencies.