bluuebunny/crossref_metadata_2025 huggingface dataset:
Campos minados (Literatura post-golpe en Chile) de Eugenia Brito (1990)
Authors: García Mendoza Francisco
Published: December 2023

La crítica literaria y poeta chilena, Eugenia Brito (1950), aparece hoy en día como una de las voces más relevantes a la hora de entender e interpretar las claves epistémicas de las producciones culturales a 50 años del quiebre de la democracia en Chile. Una de sus últimas contribuciones es la compilación antológica Cuerpos desiguales (2021), publicada bajo el sello editorial de la Universidad de Talca, que reúne la escritura poética de casi cuarenta mujeres chilenas en un recorrido cronológico que, como la misma Brito apunta, busca “[…] visibilizar las formas cómo opera el imaginario escindido de los textos de las poetas en el S.XX y en el S.XXI y de instalar los sentidos de sus producciones en la contemporaneidad” (16). Así, se puede reconocer en la labor crítica de la poeta un compromiso ineludible por leer y descifrar las producciones literarias desde un presente situado, actual y vigente, para, de ese modo, interrogar no solo las significaciones potenciales de la letra, sino que, además, del contexto histórico y social en que fueron concebidas. Similar labor es la que permite concebir la escritura y publicación de su primer libro de crítica literaria, publicado hace más de 30 años, y cuya relevancia es indiscutible en los espacios académico-literarios de hoy en día: Campos minados (Literatura post-golpe en Chile), de 1990. El libro comienza señalando los fundamentos para la revisión crítica de las escrituras de ciertas autoras y autores representativos del periodo revisado: “[…] el Golpe militar produjo un silencio y un corte horizontal y vertical en todos los sistemas culturales, entre ellos, específicamente, en la literatura” (11). En su investigación, Brito se propone descifrar las claves textuales y contextuales de las poéticas de Juan Luis Martínez, Raúl Zurita, Diego Maqueira, Diamela Eltit, Gonzalo Muñoz, Carmen Berenguer, Carla Grandi, Antonio Gil y Soledad Fariña, para sostener su hipótesis de lectura que apunta a que el Golpe militar
Linezolid-associated Hyponatremia in Section Guillain-Barré Syndrome Patients in Intensive Care unit: A Retrospective Analysis
Authors: Naik Shweta Suresh , Krishnakumar Mathangi , Mouleeswaran S , Ramesh VJ
Published: December 2023

Introduction: Guillain-Barré Syndrome (GBS) is a neurological disorder associated with ascending paralysis due to damage to the peripheral nerves by the immune system. Hyponatremia is the most common electrolyte disorder encountered in patients with GBS admitted to the Neurointensive Care Unit (NICU). Hyponatremia is associated with a poor outcome, prolonged hospital stay, and increased hospital cost. Linezolid is an oxazolidinone antibiotic used against gram-positive bacteria. The main adverse effect limiting its use is the development of myelo suppression; however, it can also cause hyponatremia. Aim: To investigate the incidence of hyponatremia in GBS patients treated with linezolid. Materials and Methods: This was a retrospective study conducted in a 14-bedded NICU at the National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India, over a period from January 2017 to January 2018. All patients with GBS who received linezolid therapy were included in the study. Out of 46 admitted patients, 16 received linezolid therapy. Final data were available for 12 patients. Hyponatremia was defined as sodium <134 mmol/L, and severe hyponatremia was defined as sodium <128 mmol/L. Descriptive statistics were used to characterise the data. The Wilcoxon signed-rank test was used to compare sodium levels before and after linezolid therapy. A p-value <0.05 was considered significant. Results: The incidence of hyponatremia was 9 out of 12 (75%). Five out of 12 patients had severe hyponatremia. There was a significant decrease of 11 (7-12) mmol/L in sodium level before and after linezolid therapy (p<0.001). The median days to develop hyponatremia were 3 (2-4) days after initiation of therapy. No mortality was observed in the study population. Conclusion: The incidence of hyponatremia is high in GBS patients treated with linezolid in the NICU. It is imperative to monitor sodium levels at frequent intervals in patients treated with linezolid to recognise and treat hyponatremia.
Comparison of Intrathecal Nalbuphine and Magnesium Sulphate for Prevention of Shivering in Caesarean Section: A Randomised Clinical Study
Authors: Angral Rajesh , Bhat Shagufta , Sheikh Tufail Ahmad , Saini Heena , Kalsotra Sanjay Kumar
Published: December 2023

Introduction: Nalbuphine and magnesium sulfate are commonly used drugs for the treatment of Perioperative Shivering (POS), but there is a paucity of comparative studies on their intrathecal use in Lower Segment Caesarean Section (LSCS) patients. LSCS is the most commonly performed obstetric surgery, and Spinal Anaesthesia (SA) is advantageous in LSCS. However, shivering has been found to be the most common side-effect of SA. Aim: To compare the effect of intrathecal injection of nalbuphine and magnesium sulfate on the prevention of postspinal anaesthesia shivering during LSCS. Materials and Methods: This randomised clinical study was conducted at the Department of Anaesthesiology, Government Medical College, Kathua, Jammu and Kashmir, India on 60 parturients between the ages of 20-40 years from September 2021 to January 2023. The participants had full-term gestation and an American Society of Anaesthesiologists (ASA) status of I or II, and were scheduled for LSCS under SA. The total sample was divided into two groups of 30 patients each. Group N (n=30) received 0.7 mg nalbuphine intrathecally, while Group M (n=30) received 25 mg of magnesium sulfate intrathecally, both with 0.5% bupivacaine (10 mg). Characteristics of spinal blockade, time to onset of shivering, severity of shivering, and side-effects such as nausea, vomiting, sedation, and hypotension were noted. Student’s t-test, Chi-square test, and Fisher’s exact test were used for data analysis. A p-value of <0.05 was considered statistically significant. Results: Both study groups were comparable in terms of age (p-value=0.081), height, weight (p-value=0.079), ASA grade (p-value=0.072), and duration of surgery (p-value=0.077). In group N, 5 patients (16.67%) had POS, while in Group M, 6 patients (20%) had POS, but the difference was not statistically significant. In Group N, 3 patients (10%) had a shivering score of 3 and 2 patients (6.67%) had a shivering score of 4, while in group M, 3 patients (10%) had a shivering score of 3 and 3 patients (10%) had a shivering score of 4. The difference was statistically insignificant. Perioperative complications (sedation, hypotension, nausea, and vomiting) were comparable in both groups with no statistically significant difference. Conclusion: Intrathecal injection of preservative-free 0.7 mg nalbuphine and 25 mg magnesium sulfate were both effective in reducing the incidence of postspinal shivering. Both drugs had comparable minimum perioperative complications. The intrathecal use of nalbuphine and magnesium sulfate for the prevention of postspinal shivering is encouraged, as both drugs are less expensive and readily available in the operation theaters.
Upper Labial Mucosa Schwannoma: A Rare Case Report
Authors: Yadahalli Roopa
Published: December 2023

An upper lip swelling, asymptomatic, and benign-looking lesion may be attributed to numerous aetiologies. About 25% to 45% of Schwannomas/Neurilemmomas occur in the head and neck region and are seldom seen in oral sites, accounting form only 1% of cases. Herein, the authors presented a case report of a 36-year-old female patient with a clinical appearance of upper labial mucosa swelling is mentioned, which mimicked a mucocele. It was a single, smooth, oval, fluctuant, and non tender swelling. Complete surgical excision was performed following proper protocol, and histological diagnosis revealed a well-outlined lesion enclosed within a fibrous capsule. The connective tissue mass of the tumour consisted predominantly of neural tissue arranged in Antoni A structures, characterised by a palisaded nuclear arrangement and the presence of distinctive eosinophilic Verocay bodies. Another area with a myxoid appearance, representing Antoni B structure, was also present, suggesting a Schwannoma/Neurilemmoma. During follow-up, complete healing with no recurrence of swelling was observed. Schwannomas/Neurilemmomas in the head and neck region are less common, particularly in the oral cavity. According to various studies, the occurrence of neurilemmomas in the intraoral aspect accounts for only 19.24% of cases, specifically involving the mucosa of the lip. Practitioners should consider this rare entity of Schwannoma/Neurilemmoma when evaluating an upper lip swelling routinely.
Assessment of Genetic Diversity in Sphenostylis stenocarpa (Hochst Ex. A Rich Harms) Using Morphological Markers
Authors: Edem U. L.  , Osuagwu A. N. , O. U. Udensi
Published: December 2023

African Yam Bean [Sphenostylis stenocarpa (L.)] as an unexploited, neglected and underutilized crop, calls for urgent attention for its breeding and improvement to avoid extinction. Fifty AYB seed samples from Idomi, Obubra, Ekoli-Edda, Abakaliki, Jos as well as IITA, Ibadan, Nigeria was assessed for genetic diversity using morphological and rbcL gene markers. Morphological characterization of AYB was carried out on twenty yield-related and yield traits. Analysis of Variance (ANOVA), Principal Component Analysis and Clustering Analysis were done using Genstat discovery Edition 4 and PASW version 20.0 software. The results revealed low genetic variations in morphological traits like pod weight, pod length, number of leaves, days to 50 % maturity, seed length and width and days to 50% flowering in different accessions investigated. Principal Component analysis generated eight principal components accounting for 57.47 % of the total variation while the hierarchical cluster analysis revealed two major clusters without traceable pattern of clustering. The relatively low genetic variation observed in the AYB accessions indicates inter-national germplasm exchange of AYB which has been a common practice among countries in Africa and Asia. Accessions from Ekoli-Edda in cluster 2 distantly clustered away from those from Abakaliki even when they were from same state. The Principal component analysis lend credence to the analysis of variance results and stems from the low degree of morphological diversity possibly due to an interaction of genetic and environmental factors. The traits which had large loading values (pod weight and length) in the first two principal component should be considered for selection in S. sternocarpa breeding programme. We conclude that there was very narrow genetic diversity in the AYB collections investigated.
Evaluation of Growth Characters of Various Genotypes of Tomato (Solanum lycopersicum L.) under Different Environment Conditions
Authors: Kaur Arshpreet , Singh Daljeet , Kamboj Prince , Singh Navdeep
Published: December 2023

The current investigation aimed to analyze growth and growth related attributes involving fifty tomato genotypes including three control varieties under low tunnel, paddy straw and open field conditions. The trial was carried out in Randomized Block Design (RBD) with three replications over two years 2020-2021 and 2021-2022 Rabi season at Faculty of Agriculture, Vegetable farm, Guru Kashi University, Talwandi Sabo, Bathinda. The analysis of variance depicted significantly high amount of variability among different genotypes for all the parameters. The maximum data for plant height was recorded in the genotype S-115 (220.54 cm) under low tunnel conditions. Maximum number of primary branches were recorded in S-115 (18.66). Days to first flowering was revealed in S-115 (33.21 days), days to first fruit set was observed in S-115 (72.56). Maximum value for days to first fruit harvest and last fruit harvest was observed in S-115 (102.56 days) and (177.24 days) respectively. The mean performances of genotypes depicted wide variations over various environments for all the parameters under research.
Quality Evaluation of Malted Pigeon Pea –Orange Fleshed Sweet Potato Flour Blends and Biscuits Using Albino (Wistar) Rats
Authors: Ayo, J. A.  , Ayo, V. I.  , Sosanya, M.  , Awogbenja, D.  , Ankel, J. A.  , Ogar, O. G.
Published: December 2023

The use of underutilized food crops and their fortification could add value to food products. Malted pigeon pea was produced and substituted into orange fleshed sweet potato at 0, 5, 10, 15, 20, and 100% to produce flour blends which was used to feed albino rats on addition of salt, bone meal, blood meal. The blend flour was also used to produce biscuits on addition of baking fat, sugar and salt. The biscuit was analysed for physical and sensory properties. The albino rat feed was analysed for nutrition and haematological qualities. The ash, protein and energy value content of the flour increased from 2.34 to 3.11, 4.64 to 13.27%, 379.83 to 384.19 Kcal/100g, respectively, with increase in added malted pigeon flour. The flavonoid, saponin, phenol, phytate, tannins contents increased from 2.11 to 3.43, 6.61 to 9.70, 0.03 to 0.07, 33.74 to 50.28, 0.04 to 0.08 mg/kg, respectively. The water absorption capacity and bulk density capacity decreased from 0.38 to 0.15% and 0.73 to 0.46 g, while the swelling, oil absorption and foam capacity increased from 1.60 to 3.65, 0.91 to 1.82 and 7.15 to 12.20%, respectively, with addition of malted pigeon pea. The highest break strength was observed in biscuit produced with 85:15 (85 % orange fleshed sweet potato, 15 % malted pigeon pea flour blends) (3000g). The Feed Efficient Ratio (FER) and the Protein Efficient Ratio (PER) of the feed albino  rats improved with addition of malted pigeon pea. The Haemoglobin (HB), Park Cell Volume (PCV), Total White Blood Cells (TWBC), White Blood Cells (WBC), Red Blood Cell (RBC) of the feed albino rats generally increased with increase in the quantity of malted pigeon pea over the three weeks feeding duration. All the blend flour biscuits were generally accepted; however, the 15% malted pigeon pea biscuit was the most preferred. Quality and acceptable biscuits can be produced from malted pigeon pea –orange fleshed sweet potato.
Yield Gap Analysis of Field Pea (Pisum sativum L.) through Cluster Front Line Demonstration under NFSM Pulses Scheme in Khowai District, Tripura, India
Authors: Sachan M. S. , Chakraborty A. , Dey D. , Shil S. , Das R. , Biswas S. C.
Published: December 2023

Enhancing the production potential and socio- economic level of farmers, altogether 325 front line demonstrations on field pea were laid out comprising 325 farmers covering the total area 160 ha with demonstration plots ranging from 0.20 to 1.0 ha during the year 2015- 16 to 2022- 23 in 14 different villages of Khowai district of Tripura to disseminate the production technology of improved varieties viz., Malviya Matar- 15 (HUDP- 15), Prakash (IPFD 1-10), Aman (IPF 5-19).  Field diagnostic visits, regular inspection, farmer’s trainings, group discussion, field days ensured application of balanced and optimum doses of nutrient, and timely plant protection measures. The productivity ranged from 11.50 to 13.50 q/ ha with average yield under demonstration recorded 12.21 q/ ha under improved technology on farmers field as against a yield ranged from 6.75 to 8.50 q/ ha with a mean of 7.52 q/ ha recorded under farmers practice. However, in the demonstration plot the yield enhancement due to technological intervention was 62.15% over the farmer’s practice. An average net returns of Rs 24,441/- at demonstrations plot, while the average net returns from farmers practice is Rs 7218. The additional cost of Rs 5440 gave additional net return of Rs. 17,223/ ha. The increased cost benefit ratio was also estimated; it ranged from 1.56 to 1.97 in recommended practices and 1.11 to 1.36 in farmers practice. An extension gap of 4.69 q/ ha was found between demonstrated technology and farmers practice, technology gap being observed 12.41 q/ ha, whereas technology index 49.87%. Therefore, cluster front line demonstration of field pea was effective for increasing the productivity of field pea and changing the knowledge, attitude and skill of the farmers. This created greater awareness and motivated the other farmers to adopt improved practices of field pea.
Impact of Capacity Building Programmes on Farmers of Hassan District of Karnataka, India
Authors: Shankara M. H. , Vasudevan S. N. , Shreenivasa K. R. , Kumar P. Naveen , Shashikiran A. S. , Desai Nagappa
Published: December 2023

The study was conducted in 5 villages of Channarayapattanataluk of Hassan district in Karnataka. The College of Agriculture, Hassan, Karnataka has conducted Rural Agricultural Work Experience Programme for the final year B.Sc (Hons.) Agriculture, B.Tech (Bio Technology) and B.Tech (Food Technology) in those 5 villages during the year 2021-22 for 3 months. The regular capacity building programmes were organized for the farmers by the students in the presence of scientists of the college. During the capacity building programmes such as training, method demonstration, exposure visits etc., the pre and post evaluation was also done to understand the knowledge and skill of the farmers about the bio agents and its application in crop production. The data was collected from 100 farmers to assessimpact of capacity building programmes on bio agentssuch as Trichoderma, Pseudomonas, Phosphate Solubilizing Bacteria etc. Thestudy reveals that, majority (78.00%) of the farmers were not aware about the availability of different bio agents in the market, 80.00 per cent of them were unaware about the importance of application of bio agents in crop production, around 89.00 per cent were not having knowledge about use of bio agents in different crops. Nearly 90.00 per cent of farmers were having poor knowledge and skill on how to use the bio agents in crop production practices. After the pre evaluation the different programmes like training programmes about the importance and application of bio agents, skill on demonstration about the bio agents treatment, exposure visits etc., were organized and conducted post evaluation also. The data from the study reveals that, there was increase in the knowledge level and skill in the application of bio agents to an extent of 25 to 30 per cent among the participants. During the year 2022, the study was conducted to assess the adoption level of farmers in the same villages about the importance and application of bio agents in their crop production practices. It was observed that, still farmers were using the bio agents in their farming practices and they were happy to share that, there was a good result in crop yield due to non incidence of pest and diseases and also due to reduced cost of pesticide application.
An Overview on (LDHs)
Authors: Sreshma C. K.
Published: December 2023

Layered Double Hydroxides are inorganic solid minerals with brucite-like structures. They are non-silicate minerals seen in the soil very rare in amount [1]. LDHs have brucite-like layers with an excess positive charge on their surface. The excess charges are balanced by anions that are present in the interlayer. Generally, LDHs are also known as Hydrotalcite-like compounds because Hydrotalcite is one of the LDHs seen commonly in soil. Due to their higher anion exchange capacity, they are also known by the name anionic clay. In nature, they generally occur as a clay mineral, but sometimes as the metabolic by-product of micro-organisms. Even humans can manufacture it at a low cost of production.
Evaluation of Induced Genetic Variability for Yield and Yield Contributing Traits in M4 Generation of Mungbean (Vigna radiata (L.) Wilczek)
Authors: Sofia S. , Reddy D. M. , Reddy K. H. P. , Latha P. , Reddy B. Ravindra , Devi M. Sreevalli
Published: December 2023

The goal of the current study was to determine how much genetic variability there was for yield and traits that contributed to yield in two different mungbean varieties, WGG-42 and LGG-460, following the induction of mutations through chemicals (ethyl methane sulphonate and sodium azide) and physical (gamma rays) mutagens. In Rabi, 2018-19, in RBD with three replications in M4generation, fifty-five mutant lines selected from M3 progenies (36 in WGG-42 and 19 in LGG-460) were assessed alongside the two parents. Number of primary branches per plant, number of clusters per plant and number of pods per plant all showed high GCV and PCV. All the characters under study have high heritability. High heritability coupled with high genetic advance as per cent of mean was recorded for plant height, number of primary branches per plant, number of clusters per plant, number of pods per plant, pod length and seed yield per plant indicating that the genetic variances for these characters are probably owing to their high additive gene effects. Our study  indicates promising avenues for future mungbean breeding programs to enhance these characteristics.
Role of Nutrients and Biofertilizers for Improved Tolerance of Tomato under Elevated Co2 Induced High Temperature Stress
Authors: Arunima A. S. , Manju R. V. , Viji M. M. , Roy S. , Sarada S. , Beena R.
Published: December 2023

The purpose of the study was to understand the role of different  nutrients and biofertilizers on the stress tolerance of the tomato variety Vellayani Vijai under elevated  CO2  induced  high  temperature condition. A pot culture study was done with  9 treatments included 50 ppm B + 50 ppm Zn + water spray (T1), 75 ppm B + 75 ppm Zn (T2), POP 150 ppm N + 125 ppm P+ 125 ppm K (T3), Azolla  (Soil application) (T4),  Azolla  biofertilizer  extract (20 %) (foliar application) (T5), Azolla biofertilizer extract (20%) (seed treatment) (T6), POP, KAU + PGPR1(T7), Control (water spray) (T8), Absolute control(T9). The application of 50% extra N and 25% extra P and K (T3) each than the recommended doses as per POP, KAU (Package of practices, Kerala Agricultural University) as well as foliar application of B and Zn at two different concentrations and foliar application of Azolla  biofertilizer  extract (20%) was found to be effective in inducing stress tolerance in tomato plants under elevated CO2 condition by improving the relative water content, cell membrane stability index and proline content.
Veterans with psychiatric disorders more prone to cannabis use disorder
Authors: Enos Gary
Published: December 2023

Newly published data indicates that within a military veteran population that has seen a rise in the prevalence of cannabis use disorder, individuals with comorbid psychiatric disorders are experiencing even greater increases. The most recent numbers show that older veterans have recently become more susceptible to cannabis use disorder than younger groups, reflecting broader national trends in cannabis use among the elderly.
Signs of recovery: Maine
Authors: de Miranda John
Published: December 2023

Recovery stuff is happening in Maine. Recent efforts described below may point the way for other states.
In Winthrop, unorthodox ways of helping drug users
Authors: Knopf Alison
Published: December 2023

A small coastal town with one road in and one road out, Winthrop, Massachusetts, is a place one might expect to be able to keep out methadone, said Winthrop Police Chief Terence Delehanty, speaking at the PAARI Summit (Police Assisted Addiction & Recovery Initiative) in Boston last week. Not so, he said.
The Grain Size Evolution Mechanism of A517Q Alloy Steel Fabricated by Laser and Wire Additive Manufacturing Assisted with Different Ultrasonic Vibration Treatments
Authors: Guo Chunhuan , Guo Dongsheng , Dong Tao , Jiang Fengchun , Qin Ruonan , Cao Mengxin , Cui Dongliang
Published: December 2023

Additive manufacturing (AM) usually leads to the epitaxial growth of columnar grains in the deposition layer along the construction direction, typically resulting in the decrease in mechanical properties. In this study, A517Q alloy steel was fabricated by laser and wire additive manufacturing (LWAM) assisted with ultrasonic vibration (UV) treatment. The microstructure characteristics of A517Q alloy steel under different UV affected were investigated by OM, XRD, SEM, and EBSD. Compared with the sample without UV, the percentage of equiaxed grains in samples with dual UV increased by 90%. Due to the optimization of grain structure, the tensile strength of the sample with dual UV increased by 29% and the elongation had also been improved. The results showed that due to the cavitation and acoustic flow effects of ultrasonic, the temperature gradient (G) of the molten pool reduced and the solidification rate (R) increased, thus promoting the transformation from columnar grains to equiaxed grains.
Molecular Engineering toward Robust Solid Electrolyte Interphase for Lithium Metal Batteries
Authors: Sun Yu , Li Jingchang , Xu Sheng , Zhou Haoshen , Guo Shaohua
Published: December 2023

Lithium‐metal batteries (LMBs) with high energy density are becoming increasingly important in global sustainability initiatives. However, uncontrollable dendrite seeds, inscrutable interfacial chemistry, and repetitively formed solid electrolyte interphase (SEI) have severely hindered the advancement of LMBs. Organic molecules have been ingeniously engineered to construct targeted SEI and effectively minimize the above issues. In this review, multiple organic molecules, including polymer, fluorinated molecules, and organosulfur, are comprehensively summarized and insights into how to construct the corresponding elastic, fluorine‐rich, and organosulfur‐containing SEIs are provided. A variety of meticulously selected cases are analyzed in depth to support the arguments of molecular design in SEI. Specifically, the evolution of organic molecules‐derived SEI is discussed and corresponding design principles are proposed, which are beneficial in guiding researchers to understand and architect SEI based on organic molecules. This review provides a design guideline for constructing organic molecule‐derived SEI and will inspire more researchers to concentrate on the exploitation of LMBs.
Electrospun‐SiO2‐Nanofiber‐Reinforced Cellulose Aerogel Loaded with ZIF‐67 for Air Filtration and Formaldehyde Adsorption
Authors: Shao Weili , Han Ruikai , Niu Jingyi , Wang Kai , Liu Simeng , Sun Ning , Li Xiang , Han Pengju , Cao Ying , Wang Yuwen , Zhang Hui , He Jianxin , Yu Hongqin , Liu Fan
Published: December 2023

Indoor air pollution, which is detrimental to the human respiratory, nervous, and cardiovascular systems, is of increasing concern because considerable time is spent indoors. Thus, there is an urgent need to develop improved methods for controlling indoor air pollution. In this study, electrospinning and freeze‐drying methods are used to prepare a cellulose–silica nanofiber (C‐SNF) aerogel loaded with zeolitic imidazolate framework‐67 (ZIF‐67) for use in indoor air purification systems. The C‐SNF aerogel doped with 0.75 wt.% SiO2 nanofiber (SNF) exhibits a maximum compressive stress of 8.7 MPa, which is higher than that (6.4 MPa) of a pure cellulose aerogel. The compressive modulus of the aerogel exceeds 85% of its original value after 100 compression cycles. The C‐SNF aerogel exhibits a filtration efficiency of 99.91% against 0.3 µm salt particles at 32 L min−1, which is higher than that of the pure cellulose aerogel (51.25%). Moreover, a stable removal efficiency of 99.92% toward 2.5 µm particulate matter (PM2.5) is observed after ten cycles. Notably, the addition of ZIF‐67 to C‐SNF (ZIF‐67@C‐SNF) aerogel by in situ growth method resulted in a porosity of 92.3% and formaldehyde removal of 93.75%. The ZIF‐67@C‐SNF aerogel can be used in various applications including indoor‐air and adsorptive‐filtration masks.
Patent ductus arteriosus and coarctation of the aorta in association with PRDM6 variants
Authors: Stanley Helen M. , White Brian R. , LaRosa Christopher J. , Cocalis Mark W. , Gaynor J. William , Strong Alanna , Gangaram Balram
Published: December 2023

Patent ductus arteriosus (PDA) and coarctation of the aorta (CoA) are relatively common congenital heart defects. Pathogenic variants in PRDM6, which encodes a smooth‐muscle‐cell‐specific transcription factor, have now been etiologically associated with non‐syndromic PDA. We present three patients with PDA and CoA found to harbor PRDM6 variants, including a novel, likely‐pathogenic variant.
Clinical audit of ultrasonography for detecting sialoliths in the submandibular gland in paediatric patients: A comparison to computed tomography and magnetic resonance imaging
Authors: Hosokawa Takahiro , Tanami Yutaka , Sato Yumiko , Adachi Nodoka , Asanuma Hiroshi , Oguma Eiji
Published: December 2023

Objectives

To compare the performance of ultrasonography with magnetic resonance imaging (MRI) and computed tomography (CT) for detecting submandibular sialoliths.

Methods

Thirteen patients with suspected submandibular sialoliths who underwent ultrasonography and CT or MRI were included. Sialoliths were diagnosed using CT (11 cases) or MRI (two cases). The submandibular duct was classified into distal and proximal ducts based on the point around the mylohyoid muscle. Sialoliths located in the proximal duct were difficult to differentiate from those located within the submandibular gland (SMG). Therefore, the location of the sialoliths was classified as follows: within the SMG/proximal duct and within the distal duct. The ultrasound results were compared with CT/MRI results.

Results

Of the 13 patients included, two had sialoliths in both the SMG/proximal duct and the distal duct, three had sialoliths in the SMG/proximal duct, and five had sialoliths in the distal duct on CT or MRI. In this small cohort, all five sialoliths in the SMG/proximal duct were detected by ultrasoonography; however, of the seven cases with sialoliths located in the distal duct, only three could be detected by ultrasonography.

Conclusions

The incidence of sialoliths in the distal duct was higher than that in the SMG/proximal duct. Ultrasonography showed a good performance compared with CT/MRI in the SMG/proximal duct but not in the distal duct.
Hearing loss and cognition: A protocol for ensuring speech understanding before neurocognitive assessment
Authors: Kolberg Elizabeth R. , Morales Emmanuel E. Garcia , Thallmayer Tara W. , Arnold Michelle L. , Burgard Sheila , Chisolm Theresa H. , Coresh Josef , Couper David , Hayden Kathleen M. , Huang Alison R. , Lin Frank R. , Mitchell Christine M. , Mosley Thomas H. , Gravens‐Mueller Lisa , Owens Tiffany A. , Pankow James S. , Pike James Russell , Reed Nicholas S. , Sanchez Victoria , Schrack Jennifer A. , Deal Jennifer A. , Goman Adele M. ,   for the ACHIEVE Collaborative Research Group
Published: December 2023

INTRODUCTION

Many neurocognitive evaluations involve auditory stimuli, yet there are no standard testing guidelines for individuals with hearing loss. The ensuring speech understanding (ESU) test was developed to confirm speech understanding and determine whether hearing accommodations are necessary for neurocognitive testing.

METHODS

Hearing was assessed using audiometry. The probability of ESU test failure by hearing status was estimated in 2679 participants (mean age: 81.4 ± 4.6 years) using multivariate logistic regression.

RESULTS

Only 2.2% (N = 58) of participants failed the ESU test. The probability of failure increased with hearing loss severity; similar results were observed for those with and without mild cognitive impairment or dementia.

DISCUSSION

The ESU test is appropriate for individuals who have variable degrees of hearing loss and cognitive function. This test can be used prior to neurocognitive testing to help reduce the risk of hearing loss and compromised auditory access to speech stimuli causing poorer performance on neurocognitive evaluation.
Poke And Delayed Drink Intertemporal Choice Task (POKE‐ADDICT): An open‐source behavioral apparatus for intertemporal choice testing in rodents
Authors: Moro Andrea Stefano , Saccenti Daniele , Seccia Alessia , Ferro Mattia , Malgaroli Antonio , Lamanna Jacopo
Published: December 2023

Advancements in neuroscience research present opportunities and challenges, requiring substantial resources and funding. To address this, we describe here “Poke And Delayed Drink Intertemporal Choice Task (POKE‐ADDICT)”, an open‐source, versatile, and cost‐effective apparatus for intertemporal choice testing in rodents. This allows quantification of delay discounting (DD), a cross‐species phenomenon observed in decision making which provides valuable insights into higher‐order cognitive functioning. In DD, the subjective value of a delayed reward is reduced as a function of the delay for its receipt. Using our apparatus, we implemented an effective intertemporal choice paradigm for the quantification of DD based on an adjusting delayed amount (ADA) algorithm using mango juice as a reward. Our paradigm requires limited training, a few 3D‐printed parts and inexpensive electrical components, including a Raspberry Pi control unit. Furthermore, it is compatible with several in vivo procedures and the use of nose pokes instead of levers allows for faster task learning. Besides the main application described here, the apparatus can be further extended to implement other behavioral tests and protocols, including standard operant conditioning. In conclusion, we describe a versatile and cost‐effective design based on Raspberry Pi that can support research in animal behavior, decision making and, more specifically, delay discounting.
Polyoxometalate Li3PW12O40 and Li3PMo12O40 Electrolytes for High‐energy All‐solid‐state Lithium Batteries
Authors: Guan De‐Hui , Wang Xiao‐Xue , Song Li‐Na , Miao Cheng‐Lin , Li Jian‐You , Yuan Xin‐Yuan , Ma Xin‐Yue , Xu Ji‐Jing
Published: December 2023

Solid‐state lithium (Li) batteries promise both high energy density and safety while existing solid‐state electrolytes (SSEs) fail to satisfy the rigorous requirements of battery operations. Herein, novel polyoxometalate SSEs, Li3PW12O40 and Li3PMo12O40, are synthesized, which exhibit excellent interfacial compatibility with electrodes and chemical stability, overcoming the limitations of conventional SSEs. A high ionic conductivity of 0.89 mS cm−1 and a low activation energy of 0.23 eV are obtained due to the optimized three‐dimensional Li+ migration network of Li3PW12O40. Li3PW12O40 exhibits a wide window of electrochemical stability that can both accommodate the Li anode and high‐voltage cathodes. As a result, all‐solid‐state Li metal batteries fabricated with Li/Li3PW12O40/LiNi0.5Co0.2Mn0.3O2 display a stable cycling up to 100 cycles with a cutoff voltage of 4.35 V and an areal capacity of more than 4 mAh cm−2, as well as a cost‐competitive SSEs price of $5.68 kg−1. Moreover, Li3PMo12O40 homologous to Li3PW12O40 was obtained via isomorphous substitution, which formed a low‐resistance interface with Li3PW12O40. Applications of Li3PW12O40 and Li3PMo12O40 in Li‐air batteries further demonstrate that long cycle life (650 cycles) can be achieved. This strategy provides a facile, low‐cost strategy to construct efficient and scalable solid polyoxometalate electrolytes for high‐energy solid‐state Li metal batteries.
P(VDF‐TrFE)‐based polymer nanocomposites comprising of reduced graphene oxide decorated with CoFe2O4@MCM 41 for efficient microwave absorption in X‐band
Authors: Anjana  , Chandra Amita
Published: December 2023

Lightweight polymer nanocomposites (PNCs) dispersed with nanofiller RGO/CoFe2O4@MCM41, namely RCM (using hydrothermal process), have been prepared and characterized. Using the solution cast technique, PNCs {(P(VDF‐TrFE)/LiTFSI/EMIMTFSI) + x wt% RCM, where x = 5, 7.5, and 10 in wt%} have been successfully synthesized. The synthesized PNCs possess good structural, thermal, mechanical, and magnetic properties because of the dispersed nanofiller within the polymeric matrix, which forms a 3‐dimensional interconnected conducting network. The optimized PFE15Li50IL7.5RCM polymer nanocomposite also exhibits total shielding effectiveness (SET) of ~19.88 dB at 9.2 GHz for a thickness of 1.18 mm corresponding to 89.07% effective absorption (Aeff) in the X‐band (8.2–12.4 GHz).
The influence and mechanism of elastomer types on electrical and mechanical properties of polypropylene insulation materials for high voltage cables
Authors: Li Xuejing , Chen Xiaolong , Liu Lu , Wei Yanhui , Hao Chuncheng , Li Shengtao , Li Guochang
Published: December 2023

Polypropylene (PP) becomes a superior candidate material for new environmentally friendly cable main insulation with its excellent heat resistance, electrical properties, and degradability. However, in practical application, PP material is aging and vulnerable and its toughness is poor. The mechanical properties of PP material can be improved by elastomer modification, but the effects of different elastomers on the comprehensive properties of composite specimens are quite different. In this paper, the electrical and mechanical properties of different types of elastomer‐modified PP composites are compared and analyzed by combining experimental and molecular simulation (MS) methods. The experimental results show that the SEBS/PP composite material has the lowest trap energy levels among all kinds of composite materials, its space charge accumulation is 1.96 × 10−9C, and the mechanical and rheological properties improvement of the composite is the most remarkable. Meanwhile, the volume resistivity is reduced by two orders of magnitude compared with pure PP. However, the breakdown strength of all kinds of composite materials decreases by different degrees after the modification. The solubility parameters (δ) and the free volume are further investigated by the molecular simulation, which shows that the δ of SEBS is similar to that of PP, which represents the best compatibility. Moreover, the SEBS/PP composite material has the strongest inter‐molecular force and the most excellent toughness improvement for PP. This work provides a theoretical basis for elastomer selection in PP modification.
Dearomative Intramolecular Diels–Alder/Sulfur Extrusion Reaction of Thiophenes with Alkynes Using peri‐Substituted Naphthalene as a Tether
Authors: Okitsu Takashi , Shinohara Yoshiki , Luo Haoran , Hatano Manabu , Yakura Takayuki
Published: December 2023

Dearomative intramolecular Diels–Alder/sulfur extrusion reaction of thiophenes with alkynes successfully afforded fluoranthenes in moderate to excellent yields. The proximity of both reactive sites fixed at the peri‐position of naphthalene would play an important role in the progress of this reaction. Tri(o‐tolyl)phosphine effectively suppressed the side reactions as a sulfur scavenger.
Green fluorescent carbon dots for sensing of quercetin and pH and cell imaging
Authors: Zhang Yaqing , Cheng Sijie , Zhang Yong
Published: December 2023

Green fluorescent carbon dots (G‐CDs) were fabricated from Coptis chinensis directly via one‐step hydrothermal treatment for the determination of quercetin (QCT) and pH sensing. The obtained G‐CDs have low cytotoxicity, good photostability and excellent water solubility. The optimal excitation wavelength and emission wavelength were 480 and 530 nm. A remarkable emission reduction displayed when QCT was added to the G‐CDs and the linear detection range is 0–200 μM, the limit of detection is 4.41 nM. The proposed method was applied to the determination of QCT in Haerbin beer products with satisfactory successful recovery. Furthermore, the G‐CDs exhibited sensitive changes to pH and two fluorescent pH sensors in the linear ranges of 2.0–6.0 and 6.0–11.0 were constructed based on this. They also provide a feasible method to measure the pH value of real water samples. Importantly, the fluorescent sensor has been extended to detect QCT in yeast cell, demonstrating the G‐CDs present potential biosensing application prospect.
Determination of flurbiprofen in rat plasma using ultra‐high performance liquid chromatography–tandem mass spectrometry and its application in a pharmacokinetic study
Authors: Zhao Xihong , Lv Chunjing , Chen Hong , Qin Feng , Lu Xiumei
Published: December 2023

A rapid and sensitive ultra‐high performance liquid chromatography–tandem mass spectrometry method was developed to determine flurbiprofen in rat plasma. A triple quadrupole tandem mass spectrometer equipped with an electrospray ionization (ESI) source was used in negative ion mode. Acetonitrile precipitation was selected to prepare samples. Flurbiprofen and internal standard flurbiprofen‐d5 were analyzed on an Acquity UPLC BEH C18 column with the mobile phase consisting of acetonitrile and water, and a gradient procedure was used for separation. The retention time of flurbiprofen was 0.67 min, and the whole running time was only 1.2 min. The detection was performed on a triple quadrupole tandem mass spectrometer using multiple reaction monitoring mode via an ESI source with optimized mass spectrometry parameters. The calibration curve was linear in the range of 25.0–1.00 × 104 ng/mL (r ≥ 0.99). The within‐run and between‐run relative standard deviations were not more than 13.9%. The within‐run and between‐run relative errors were from −9.0% to 3.4%. There was no significant matrix effect, and recovery was high. This method was fully validated, including whole blood stability in rat plasma, and successfully applied to the pharmacokinetic study in which 100% incurred sample reanalysis met the criteria.
Identification of AP002498.1 and LINC01871 as prognostic biomarkers and therapeutic targets for distant metastasis of colorectal adenocarcinoma
Authors: Wu Na , Chen Jingyi , Lin Tingru , Zhong Zhaohui , Li Mei , Yu Yimeng , Guo Jingzhu , Yu Weidong
Published: December 2023

Background

Increasing evidence suggests that lncRNA (Long non‐coding RNA, lncRNA)‐mediated ceRNA (competing endogenous RNA, ceRNA) networks are involved in the occurrence and progression of colorectal cancer (CRC). However, the roles of the lncRNA–miRNA–mRNA ceRNA network in distant metastasis of CRC are still unclear.

Methods

In this study, we constructed a specific ceRNA network to identify potential biomarkers and therapeutic targets for distant metastasis of CRC. Specifically, RNA‐Seq data from The Cancer Genome Atlas (TCGA) were used to screen for differentially expressed lncRNAs (DElncRNAs) and mRNAs (DEmRNAs) related to metastasis. After validation and selection by qRT–PCR and univariate and multivariate analysis of the metastasis‐ and prognosis‐related lncRNAs, the regulated microRNAs (miRNAs) and coexpressed mRNAs were used to construct a ceRNA network for distant metastasis of CRC.

Results

Two key distant metastasis‐related DElncRNAs, AP002498.1 and LINC01871, were identified by univariate and multivariate analysis in combination with analyses of clinical data and expression levels. Furthermore, lncRNA‐associated ceRNA subnetworks were constructed from the predicted miRNAs and 13 coexpressed DEmRNAs (SERPINA1, ITLN1, REG4, L1TD1, IGFALS, MUC5B, CIITA, CXCL9, CXCL10, GBP4, GNLY, IDO1, and NOS2). The AP002498.1‐ and LINC01871‐associated ceRNA subnetworks regulated the expression of the target genes SERPINA1 and MUC5B and GNLY, respectively, through the associated miRNAs.

Conclusion

The DElncRNA AP002498.1 and the LINC01871/miR‐4644 and miR‐185‐5p/GNLY axes were identified as being closely associated with distant metastasis and could represent independent prognostic biomarkers or therapeutic targets in colorectal adenocarcinoma.
Transcatheter mitral valve replacement with Mi‐thos system: First‐in‐human experience
Authors: Yang Ye , Chen Jinmiao , Dong Lili , Lu Yuntao , Lv Minzhi , Guo Kefang , Bagaber Ghufran , Yang Jian , Wang Chunsheng , Wei Lai
Published: December 2023

Background

Transcatheter mitral valve replacement (TMVR) has become an alternative for high‐risk patients with severe mitral regurgitation (MR). The aim of this study was to evaluate the safety and feasibility of the Mi‐thos TMVR system (NewMed Medical) for high‐risk patients with severe MR.

Methods

This was a prospective, two‐center, single‐arm early feasibility study. Baseline characteristics, procedural data and 30‐day follow‐up outcomes were collected and analyzed. The primary endpoint was intraoperative success rate of device implantation. The second endpoints were all‐cause mortality and major post‐procedural complications. Echocardiographic data were evaluated by an independent core laboratory. Clinical events were adjudicated by a clinical events committee.

Results

Ten high‐risk patients with severe MR were enrolled at two sites from August 2021 to November 2022. The median age was 70.5 years, and 60% of patients were female. The median Society of Thoracic Surgeons Predicted Risk of Mortality was 9.5%. The Mi‐thos TMVR system was successfully implanted via transapical access in all patients. There was no pericedural mortality or major postpericedural complications during the 30‐day follow‐up. All implanted prosthetic valves had no or trace valvular or paravalvular MR, and the median mitral valve gradient at 30 days was 2.0 mmHg (IQR: 2.0–3.0 mmHg). There was one mild left ventricular outflow tract obstruction.

Conclusions

The favorable short‐term outcomes of the Mi‐thos TMVR system demonstrated that it might be a feasible and safe therapeutic alternative for high‐risk patients with severe MR. Nevertheless, further evaluation of the Mi‐thos TMVR system is warranted.
Frailty and mini dental implants
Authors: Flanagan Dennis
Published: December 2023

Patients who have been diagnosed as frail and have atrochic jaws may have a dramatic increase of quality of life with mini implant treatment for retention of a mandibular complete denture.
A rare case of dual coronary cameral fistulae
Authors: Ozgur Sacide S. , Shamoon Yezin , Abboud Rachel , Shaqra Hussein , Shamoon Fayez
Published: December 2023

Key Clinical Message

Dual coronary cameral fistulae (CCFs) are rare abnormal connections between coronary arteries and heart chambers. Management of CCFs remains a topic of debate, emphasizing the need for individualized approach based on presentation.

We present a rare case of dual coronary cameral fistulae originating from the mid‐left anterior descending (LAD) and the mid‐right coronary artery (RCA) with drainage into the left ventricle, diagnosed incidentally during coronary angiography.
Spontaneous hemothorax caused by rivaroxaban treatment for pulmonary embolism: A case report
Authors: Al Hariri Bassem , Alharafsheh Ahmad Taher , Hassan Muad Abdi , Nashwan Abdulqadir J. , Mohamedali Mohamed Gaafar , Abusriwil Hatem Mabrouk
Published: December 2023

Key Clinical Message

Hemothorax is a rare and potentially fatal condition characterized by pleural effusion containing over 50% of the patient's hematocrit. A massive hemothorax involves blood loss exceeding 1.5 L. Common causes include chest trauma, invasive thoracic procedures, anticoagulant medications, vascular anomalies, malignancies, and hematologic abnormalities. Spontaneous hemothorax may be seen in conjunction with pulmonary infarction and spontaneous pneumothorax. Anticoagulation is a key therapeutic strategy for certain thromboembolic events, such as pulmonary embolism. Historically, these events were treated with vitamin K antagonists (VKAs), which have demonstrated variable plasma concentrations and an increased risk of hemorrhage. With the advent of direct oral anticoagulants (DOACs), treatment has become as effective as VKAs while significantly reducing the risk of hemorrhage. However, some researchers have speculated that hemorrhagic complications in certain cases could be worse with DOACs than with VKAs. In the case presented here, we identified a genuine association between the use of rivaroxaban and spontaneous hemothorax following the initiation of treatment for pulmonary embolism.