bluuebunny/crossref_metadata_2025 huggingface dataset:
Preventing Bullying Behavior In Adolescents With Counseling And Roleplay At Smp Negeri 2 Palang, Palang District,Tuban Regency
Authors: TRI NINGSIH WAHYU , Titik sumiatin
Published: April 2022

Bullying merupakan salah satu perilaku berisiko pada remaja, bisa jadi merupakan fenomena gunung es karena perilaku bullying dikalangan remaja bukan hal yang baru. Perilaku negatif ini kemungkinan besar banyak dilakukan karena mereka pernah menjadi korban bullying dari seseorang yang lebih kuat, misalnya, orang tua, kakak kandung, kakak kelas, atau teman sebaya. Tujuan dari kegiatan pengabdian kepada masyarakat ini adalah untuk meningkatkan pengetahuan siswa tentang bullying, meningkatkan sikap siswa, dan menurunkan perilaku bullying siswa di SMPN 2 Palang, Kecamaan Palang, Kabupaten Tuban. Metode yang digunakan pada kegiatan ini adalah penyuluhan dan roleplay. Sasaran pengabdian masyarakat ini adalah siswa SMPN 2 Palang, Kecamatan Palang, Kabupaten Tuban berjumlah 80 orang. Media yang digunakan adalah modul, LCD, dan laptop. Hasil dari kegiatan ini adalah pengetahuan siswa mengalami peningkatan, sikap siswa semua menyatakan  perilaku bullying merupakan perilaku yang sangat negatif, dan  terjadi penurunan perilaku bullying. Kegiatan penyuluhan tentang bullying perlu dilakukan secara berkesinambungan dengan melakukan kerja sama lintas sektor dan melibatkan berbagai pihak sehingga  perilaku bullying dapat dicegah
High Synthetic Audio Compression Model Based on Fractal Audio Coding and Error-Compensation
Authors: Ali Ahmed Hussain , George Loay Edwar
Published: April 2022

This study presented a model for improving audio files quality using fractal coding specifically when a high compression ratio is required. The proposed high synthetic audio compression model which can be called (HSACM) is based on conventional fractal coding and lifting wavelet transform. Various lifting wavelet transform families and levels are used and their effects on the reconstructed audio files are discussed as well. Audio files from GTZAN dataset and standard measurements for data compression are used in the evaluation of the proposed model. The results reveal that using block length 50 samples which is the worst case, PSNR is increased, on average, from 34.1 to 44.8 dB and from 34.1 to 40.5 dB using lifting wavelet transform with 3 and 2 levels, respectively. Thus, the PSNR is improved by 10 and 5 dB with slightly reducing the compression ratio by 6.2 and 12.5%, respectively. Moreover, it can be noticed that adopting lifting wavelet transform with basis Haar, db1, db4, db5, cdf1.1 and cdf2.2 provide higher audio quality while db6, db8, sym7 and sym8 give the worst audio quality. Furthermore, the performance of HSACM is compared with that of existing work to highlight its performance.
Frecuencia del mantenimiento de elementos estructurales de puentes colgantes de cinco toneladas en Morona-Santiago
Authors: Berrezueta Torres Juan Carlos , Calle Castro Carlos Julio , Cárdenas Sánchez Andrés Eduardo
Published: April 2022

Introducción. Los puentes constituyen una parte principal de las obras de infraestructura vial de un País y por tanto los objetivos de la Ingeniería, son asegurar su conservación y funcionamiento con seguridad. La correcta gestión que pueda desarrollar un operador de infraestructura depende de la información que dispongan respecto al comportamiento de los elementos, su desgaste y el conocimiento de las patologías que puedan afectarlos. Sin embargo, en el ámbito local, dentro del Gobierno Autónomo Descentralizado Provincial de Morona-Santiago (GADPMS), Ecuador; no se ha logrado identificar ningún manual para la correcta operación de puentes colgantes. Metodología. Frente a este problema, se plantea una investigación a nivel descriptivo, en la que se busca medir, mediante observación recurrente, el porcentaje de daño presente en perfiles estructurales y péndolas de puentes colgantes carrozables que han sido sometidos a mantenimientos durante los años 2019 y 2020. Con el procesamiento de la información obtenida se busca proponer una planificación en la que se defina la frecuencia con la que se debe intervenir en el mantenimiento de elementos estructurales de puentes colgantes carrozables de Morona-Santiago con capacidad de carga igual o menor a cinco toneladas, para el período 2022-2023.
Análisis de cantidades de obra obtenidos mediante los métodos tradicionales de construcción versus metodología BIM
Authors: Chaca Guamán Iván Patricio , Ortega Castro Juan Carlos , Moscoso García Pedro Alex
Published: April 2022

El presente artículo realiza una comparación entre la metodología tradicional utilizada para obtener cantidades de obra en nuestro medio, versus la metodología digital BIM. Para lograr lo anteriormente mencionado se procede a recopilar información de tipo científica en repositorios digitales, como: Redalyc, Scielo, Scopus, Google académico y las leyes o normas utilizadas en los procesos de consultoría del Ecuador, con el objetivo de tener la información necesaria para generar esta comparación. Los datos se han obtenido de proyectos diseñados mediante la herramienta BIM y estos mismos proyectos fueron analizados mediante la metodología tradicional. Seguidamente se procede a analizar esta información de una manera comparativa y correlacional, en la cual se consideran 2 etapas, una al cuantificar las cantidades de obra y en la segunda etapa cuantifica el tiempo utilizado, la cantidad del personal y el conocimiento del mismo para cada uno de los métodos, se concluye que la metodología BIM, logra tener mayor exactitud, y, es más rápida de utilizar, sin embargo, necesita de profesionales mejor capacitados, lastimosamente, según las leyes del Ecuador, la metodología BIM no puede ser aplicada de manera eficiente.
DEVELOPING OF STORY WRITING TEACHING MATERIALS FOR ELEMENTARY SCHOOL IN THE INDEPENDENT ERA LEARNING SOCIETY 5.0 BASED ON LOCAL WISDOM
Authors: Setyowati Endang , Susilawati Lis
Published: April 2022

Given the swift currents of globalization and making it easier for foreign cultures to enter and influence the younger generation in Indonesia, especially children. In addition, teaching materials are also needed whose approach is in accordance with the times. Therefore, the researchers developed an elementary school teaching material that was in accordance with the independent era of learning society 5.0 based on local wisdom. The general objective of this research is to produce a product in the form of teaching materials for writing children's stories in the independent era of learning society 5.0 based on local wisdom. The specific objectives of this research are (1) to produce learning materials for writing children's stories in the independent era of learning society 5.0 based on local wisdom, and (2) describing the feasibility of teaching materials to write children's stories in the independent era of learning society 5.0 based on local wisdom that has been developed.The research model used is the Borg and Gall research model. The research model used by Borg and Gall is the Research and Development (R & D) approach. The results obtained from the validation carried out by content (material) experts, namely 87% with the validity level being quite valid with small revisions, and validation by learning media experts, namely 85% with the validity level being quite valid and requiring minor revisions. The results of the development of teaching materials for writing children's stories in the independent era of learning society 5.0 based on local wisdom for elementary school students, especially grades IV until VI in Malang is at 83%, which means that the teaching materials for writing children's stories are suitable for use.
STUDIES OF SOCIOLINGUISTICS: THEORY OF POLITENESS IN ENGLISH AS SECOND LANGUAGE
Authors: Gumartifa Asti
Published: April 2022

In the social study of language, linguistic politeness has played a central role. Politeness in speaking English is also part of sociolinguistic and pragmatic learning. Each country has a variety of cultures and language accuracy in communication. Unfortunately, most learners don’t speak English based on the sociolinguistics features and it is influenced by the culture, gender, language style, and domain. Therefore, there are still some issues to the practice of politeness linguistics to the English as a second language. The study of qualitative research was used in this study method. The purposes of this research are to inform eight theories of politeness application, the concept of face in politeness, and various types of politeness which are also explained by the division and classification of politeness.  To support the students’ information about politeness in linguistics, some existing research information is discussed in this research.
Prevalence and distribution of Renibacterium salmoninarum, causative agent of bacterial kidney disease, in wild trout fisheries in Colorado
Authors: Kowalski DA , Cordes RJ , Riepe TB , Drennan JD , Treble AJ
Published: April 2022

Detections of Renibacterium salmoninarum in Colorado USA fish hatcheries have become more frequent in recent years, including one disease outbreak that originated with a wild broodstock. Our objectives were to document the prevalence and distribution of R. salmoninarum in Colorado’s wild trout fisheries, investigate variables that influence that distribution, and evaluate the effectiveness of common testing methods on non-anadromous trout. We sampled wild trout across Colorado and tested kidney tissue with enzyme-linked immunosorbent assay (ELISA), quantitative polymerase chain reaction (qPCR), nested polymerase chain reaction (nPCR), and direct fluorescent antibody test (DFAT). Screening with ELISA showed high prevalence of R. salmoninarum among fish populations, but antigen levels were low. No clinical disease was observed in any of the fish sampled despite the antigen of R. salmoninarum being common. Antigen levels measured by ELISA increased in smaller streams with lower historic fish stocking rates. Brook trout Salvelinus fontinalis had the highest prevalence of the bacterium among fish species and highest ELISA antigen levels. The distribution of brook trout in the smallest streams may help explain the patterns of R. salmoninarum across the landscape. The most effective assays for screening wild trout were qPCR and ELISA; DFAT was inconsistent for bacterial levels encountered in wild trout and generally uninformative. Additionally, qPCR and ELISA can provide quantitative information about bacteria levels. The bacterium R. salmoninarum is ubiquitous in Colorado trout fisheries but is generally found at low levels. Active infections are rare and overt bacterial kidney disease appears more common in Colorado hatcheries than in wild fish.
Satellite tags describe movement and diving behaviour of blue sharks Prionace glauca in the southwest Pacific
Authors: Elliott RG , Montgomery JC , Della Penna A , Radford CA
Published: April 2022

The blue shark Prionace glauca is the most abundant, widely distributed and exploited pelagic shark species. Its population is declining in almost all major oceanic basins. Population management and conservation efforts have traditionally depended on fishery bycatch and observer data. Recent studies correlating animal distribution derived from satellite tags, with commercial fishery impacts, across multi-jurisdictional regions, have provided an improved data platform for population management. Here we present the first fishery-independent data of blue shark distribution in the southwest Pacific Ocean. Fifteen blue sharks were satellite tagged, adding to the global dataset of approximately 179 individuals successfully tracked using bolt-on satellite tags. Smart Position and Temperature (SPOT) tags transmitted between 66 and 505 d, and SPLASH tags between 200 and 343 d. Individual track lengths ranged from 3000 to 14559 km, spanning 10 exclusive economic zones, from latitudes 0.1° to 43.1°S, and longitudes 160.1°E to 150.8°W. Horizontal movements revealed age/sex segregation and large-scale horizontal migration patterns. Dive data collected with SPLASH tags showed fine-scale vertical habitat use at depths between 0 and 1364 m and temperatures of 5 to >30°C. Behavioural events, such as foraging, searching and travelling, were inferred from commonly repeated patterns in the retrieved dive profiles. This study provides a characterisation of critical habitat use in a region never before sampled, adding to the global understanding of blue sharks, and the fishery-independent database necessary to inform blue shark population management.
PELATIHAN DAN PENDAMPINGAN PENULISAN METODOLOGI PENELITIAN BAGI MAHASISWA TINGKAT AKHIR MELALUI DARING
Authors: Winadi Prasetyoning Tyas Ari Anggarani , Ummanah Ummanah
Published: April 2022

Metodologi Penelitian merupakan bagian terpenting dalam suatu pelaksanaan penulisan karya ilmiah, yang mana pemahaman akan metodologi penelitian ini sudah harus diperkenalkan sejak awal. Oleh karena itu, pada kegiatan pengabdian ini dilakukan Pelatihan untuk mahasiswa tingkat akhir yang sedang melaksanakan penelitian sebagai proyek akhir perkuliahannya. Hal ini dilakukan karena kurangnya tingkat pemahaman terhadap metodologi penelitian dan minimnya pengetahuan serta keahlian dalam proses analisis data.  Dengan memanfaatkan metode direct action, kegiatan pengabdian ini memiliki tujuan untuk memecahkan permasalahan tersebut dengan mengadakan kegiatan pelatihan serta pendampingan penulisan dan metodologi penelitian. Adapun Luaran yang diperoleh mahasiswa yaitu dalam bentuk proposal penelitian serta laporan penelitian yang menjadi bukti pemahaman mahasiswa terhadap metodologi penelitian serta analisis data.
PELATIHAN PENGGUNAAN UAV DALAM PENGAMBILAN GAMBAR PETA TOPOGRAFI PADA JURUSAN BKP SMKN 5 PEKANBARU
Authors: Djusar Syahtriatna , Fajrizal Fajrizal , Anggraini Keumala
Published: April 2022

Bisnis Konstruksi dan Properti merupakan salah satu program keahlian di SMK Negeri 5 Pekanbaru yang mempelajari seputar perkembangan bisnis bidang properti dan pembangunan. Untuk mendukung pencapaian salah satu keterampilan yang dapat menunjang kompetensi lulusan SMK Negeri 5 Kota Pekanbaru, yaitu pengunaan pesawat tanpa awak atau Unmanned Aerial Vehicle (UAV), maka Fasilkom Unilak melaksanakan kegiatan ini yang dilaksanakan dalam bentuk teori dan praktek. Kegiatan ini di ikuti oleh 15 orang siswa kelas XII SMKN 5 Pekanbaru dari program studi Bisnis Konstruksi dan Properti. Setelah dilakukan evaluasi pada akhir kegiatan, maka semua peserta mendapatkan peningkatan pengetahuan dan keterampilan terkait 9 materi pelatihan. Kesimpulan dari kegiatan ini, dengan adanya sarana dan sumber daya manusia pada perguruan tinggi, jika di kolaborasikan dengan sekolah, akan dapat mendukung dan menjembatani proses pembelajaran di sekolah.
GERAKAN SATU TITIK PENGABDIAN (G1TP) SEBAGAI WUJUD PENINGKATAN KETERAMPILAN TIK DAN LITERASI DIGITAL MASYARAKAT
Authors: Arianti Baiq Desi Dwi , Kholisho Yosi Nur , Wirasasmita Rasyid Hardi , Uska Muhammad Zamroni , Ismatulloh Kholida , Jamaluddin Jamaluddin , Kuswanto Heri , Lutfi Samsul , Fathoni Ahmad
Published: April 2022

Di era digital saat ini, kemampuan TIK dan literasi sangat dibutuhkan. Hal ini dikarenakan mudahnya masyarakat termakan berita bohong atau lebih dikenal dengan HOAX. Oleh karena itu, kegiatan Pengabdian ini bertujuan untuk mendampingi dan meningkatkan kemampuan TIK dan literasi digital bagi siswa siswi SMK dan MA di Desa Tembeng Putik. Metode yang digunakan yaitu melalui pelatihan dan praktik langsung, serta penyampain materi melalui ceramah dan diskusi. Materi pelatihan berupa Photoshop dasar, Micrososft Words dasar, instalasi komputer, dan pemanfaatan teknologi dalam literasi digital. Secara keseluruhan hasil yang didapatkan yaitu terbentuknya pemahaman dan kemampuan peserta dalam memanfaatkan TIK, baik penggunaannya dalam literasi digital, instalasi komputer, maupun dalam penggunaan perangkat lunak yang diajarkan. Hampir semua peserta mampu mengoprasikan aplikasi yang diajarkan, sehingga tujuan dari kegiatan ini tercapai.
Design of Web-Based Helpdesk Ticketing System at PT DENSO Indonesia
Authors: Wonohardjo Eduard Pangestu , Putra Annan Hutomo , Yossy Emny Harna
Published: April 2022

PT DENSO Indonesia currently has a helpdesk ticket system based on IBM Lotus Notes. The system is currently not being used optimally because it has limited features, depends on the platform provider, and the source code is difficult to develop. The company has also taken a policy this year not to continue the subscription process to the platform provider. The purpose of this study is to analyze the current business processes and propose a new system model that is computerized, as needed, reliable, and does not depend on a particular platform. The system was developed based on a website using the Extreme Programming (XP) method as a Software Development Life Cycle (SDLC), Unified Model Language (UML) notation as document design, and calculation of completion rate and time-based efficiency in measuring system effectiveness and efficiency. The website-based helpdesk ticketing system was successfully implemented as a new system model that runs independently and has easy-to-develop source code. The system also has a completion rate of 86% and a time-based efficiency of 0.00924 goal/sec based on a problem reporting scenario with 15 participants.
Two-Lift Concrete Pavements Constructed Under SHRP2 Project R21 Implementation Effort
Authors: Smith Kurt , Ram Prashant , Snyder Mark
Published: April 2022

Two-lift concrete pavements use two separate lifts of concrete that are placed in a wet-on-wet process to produce a monolithic structure. Although not new, two-lift concrete pavements are an innovative approach to optimizing the characteristics of each layer and, hence, the overall pavement structure. In 2014, the Federal Highway Administration (FHWA), working in collaboration with the American Association of State Highway and Transportation Officials (AASHTO), selected two-lift composite pavements for funding under the SHRP2 Implementation Assistance Program (IAP). Under that initiative, the design and construction of three composite pavement projects featuring two-lift concrete paving were sponsored. This paper summarizes some of the key design and construction details for each of these three projects, and also provides recommendations on the general applicability and selection of two-lift concrete pavements.
A Survey Method for Measuring Load Transmission Rates in Concrete Pavements Covered Using Asphalt
Authors: Ueta Tomotaka , Matsushita Ikuo , Takejiri Kenichi , Yamashita Atsuma , Koyanagawa Masashi
Published: April 2022

National Road No.17 starts from Nihonbashi (which means the name of Bridge in Tokyo) and connects the metropolitan area and Northwestern Region of Japan. Among them, Omiya Bypass which runs through the central area of Saitama Prefecture was started as concrete pavement in 1963. However, damage to concrete slabs and joints progressed due to increasing the large car traffics and deteriorations, at present, it has been changed to the overlaid structure with asphalt pavement on a concrete slab (3.25mx10m). In recent year, in Omiya Bypass, cracks on the road surface and vibrations become noticeable and repair work is being carried out from the high urgency area with priority.　From a large-scale research implemented in 2017, the cause of vibration is considered to be the impact of passing large vehicles and cracks occur on the road surface due to damage (break of Dowel bar, gap) near the joints of concrete plates that laid under asphalt. Surface cracks can be used to determine the damage status by road surface survey but joints in asphalt covered concrete slabs cannot be surveyed directly and the efficient investigation is required because the repair wide range extending. In this paper, in order to evaluate the soundness of the joints between asphalt covered concrete slabs we can describe the content of the method of efficiently investigating the load transfer rate which is one of the items to evaluate the joints.
Future Directions and Implementation Strategies for Concrete Pavement Design and Construction
Authors: Snyder Mark , Van Dam Thomas , Ram Prashant , Smith Kurth , Yu H. Thomas
Published: April 2022

The U.S. Federal Highway Administration (FHWA) hosted a ``Concrete Pavement Strategic Planning Meeting'' in August 2019 for the purposes of 1) identifying future needs and directions in concrete pavement design, and 2) the development of strategies to increase the implementation of long-life concrete pavement (LLCP) design and construction. The meeting was attended by an Expert Task Group (ETG) of knowledgeable concrete pavement experts and practitioners representing highway agencies, academia, industry partners and the Federal Highway Administration (FHWA). Many of the strengths and limitations of current concrete pavement design procedures were identified and discussed. It was recognized that AASHTOWare PavementME Design and other similarly sophisticated procedures represent a significant technological leap over empirical design procedures with which they compete (and often replace). However, there are concerns about performance model limitations, the cost-effectiveness of local calibration efforts, the emphasis on surface thickness design (often assuming, rather than designing, support conditions), and other issues. The potential service and economic benefits of LLCP were also discussed. The impetus for implementation (and benefits documented) by some agencies were described, as were the impediments to implementation for other agencies. Strategies were developed to help overcome the impediments identified and to facilitate broader use of LLCP. This paper summarizes key points raised on each of these issues and includes recommendations for future directions in concrete pavement design and increased implementation of LLCP.
Paste Curing Effectiveness with Contactless Sensing and 2D Wavefield Analysis
Authors: Tran Quang , Roesler Jeffery
Published: April 2022

The serviceability and performance life of concrete pavement are improved by temperature and moisture management during the initial cement reactions, which has been done successfully by various curing methods and compounds. However, the effectiveness of all curing compounds and methods has been difficult to measure spatially and rapidly in the field. In this paper, a new contactless ultrasonic testing system (UTS) and 2D wavefield analysis are introduced to evaluate the effectiveness of curing methods and compounds through monitoring of the near-surface damage of early-age hydrating paste. Cement paste specimens were cast and exposed to elevated drying conditions (23 C air temperature, 46% humidity, and 6.6 m/s wind speed) while subjected to no curing, plastic cover curing, and a wax- based compound. The UTS employed a fully contactless 50kHz ultrasonic transmitter and an array MEMS receivers. The paste specimens were monitored at ages 1, 4, 7 days after casting for the evolution of near-surface cracking. The non-contact UTS monitored the energy of leaky Rayleigh waves (LR-waves) signal over time and analyzed the frequency-wave number (f-k) domain to characterize the quantity of near-surface damage in the cement paste specimens. An ultrasonic surface damage index (USDI) was defined from f-k wavefield domain based on the ratio of the non- propagating and forwarding LR-waves. The contactless sensing and 2D wavefield analysis easily distinguished the specimen damage differences between the no curing surface, the plastic sheet cover cure, and the wax-based curing. Surfaces with low surface damage had little to zero non-propagating wave energy, which was seen in the wax-based curing specimens and the unexposed bottom surfaces of all cast specimens.
10+ Years of Experience in Concrete Slabs with Optimized Geometry
Authors: Covarrubias Juan Pablo , Del Rio B Pelayo , Binder Carlos
Published: April 2022

In 2005, a new concept in concrete pavements was developed, Concrete Slabs with Optimized Geometry. This technology is based on designing the concrete slabs so that no more than one wheel or set of wheels will be loading the same slab at any time. This causes the slabs to work in a different way than usual, decreasing stresses and allowing a reduction in thickness, when compared to a traditional concrete pavement design. All without reducing its lifespan and increasing its fatigue resistance. Since 2005 there have been important developments of this technology. With more than 129 million square feet (12 million square meters) in application, 200 projects across 10 countries, the technology has been used in many different climates and loading conditions. All this information has helped to calibrate and understand the behavior of this new system. This paper shows the most important things we have learned in the last 10+ years, also explanation of the development and protection for the technology.
Kinerja Karyawan Berbasis Etos Kerja Dan Disiplin Kerja Pada PT Global Edutek Solusindo di Tangerang Selatan
Authors: Meilinda Rineska , Sunarto Ading , Ellesia Nindie
Published: April 2022

The purpose of this study was to determine how much influence work ethic and work discipline had on employee performance at PT. Global Edutek Solusindo South Tangerang. The method used in this research is quantitative analysis with a population of employees of PT. Global Edutek Solusindo South Tangerang as many as 60 respondents or samples. with data collection techniques by distributing questionnaires. The data analysis methods used in this research are (validity test, reliability test and classical assumption test), quantitative descriptive analysis, simple and multiple regression analysis, and correlation and determination coefficient analysis, hypothesis testing (T and F test). The results of the research on the work ethic variable have a tcount value greater than ttable (6.145 > 2.002) and a significant value less than 0.05 (0.000 < 0.05). the results of research on work discipline variables. (F test) The results of this study the Fcount value of 66,221 is greater than Ftable of 3.15 (66,221 > 3.15) and the significance value of 0.000 is less than 0.05 (0.000 < 0.05). So it can be concluded that work ethic and work discipline have a positive and significant impact on the performance of PT. Global Edutek Solusindo South Tangerang was 0.689 or 68.9% while the rest was 0.311 or 31.1%.

Abstrak

Tujuan dari penelitian ini untuk mengetahui seberapa besar pengaruh etos kerja dan disiplin kerja terhadap kinerja karyawan pada PT. Global Edutek Solusindo Tangerang Selatan. Metode yang di gunakan dalam penelitian ini adalah analisis kuantitatif dengan populasi karyawan PT. Global Edutek Solusindo Tangerang Selatan sebanyak 60 responden atau sampel. dengan teknik pengumpulan data dengan cara penyebaran kuesioner. Metode analisis data yang digunakan dalam penelitian ini adalah (uji validitas, uji reliabilitas dan uji asumsi klasik), analisis deskriptif kuantitatif, analisis regresi sederhana dan berganda, dan analisis koefisien korelasi dan determinasi, uji hipotesis (uji T dan F). Hasil penelitian variabel etos kerja memiliki nilai thitung lebih besar dari ttabel (6.145 > 2.002) dan nilai signifikan lebih kecil dari 0,05 (0.000 < 0,05). hasil penelitian variabel disiplin kerja. (uji F) Hasil penelitian ini nilai Fhitung sebesar 66.221 lebih besar dari Ftabel sebesar 3.15 (66.221 > 3.15) dan nilai signifikansi sebesar 0.000 lebih kecil dari 0,05 (0.000 < 0.05). Maka dapat disimpulkan bahwa etos kerja dan disiplin kerja memberikan pengaruh positif dan signifikan tehadap kinerja karyawan PT. Global Edutek Solusindo Tangerang Selatan sebesar 0,689 atau 68,9% sedangkan sisanya sebesar 0,311 atau 31,1%.

Kata Kunci: Etos Kerja, Disiplin Kerja dan Kinerja Karyawan
Pengaruh Promosi dan Kualitas Produk Terhadap Keputusan Pembelian Pada PT Sinergia Beaute Indonesia Jakarta Pusat
Authors: Munarsih Munarsih , Matahari Sabila Aulia
Published: April 2022

The purpose of this research is to determine the effect of promotion and product quality partially or simultaneously on purchasing decisions at PT. Sinergia Beaute Indonesia, Central Jakarta. The method used is descriptive quantitative analysis method. The population in this research were consumers of PT. Sinergia Beaute Indonesia as many as 2.318 people. The sampling technique used non-probability sampling with purposive sampling type. The sample of this research was determined using the Slovin formula as many as 96 respondents. The data instrument test in this research used validity, reliability, and classical assumption tests. The data analysis technique used simple linear regression test, multiple linear regression test, determination test, and hypothesis test. The results of this research indicate that partially, promotion has a positive and significant effect on purchasing decisions. Product quality has a positive and significant effect partially on purchasing decisions. Promotion and quality product have a positive and significant effect simultaneously on purchasing decisions.

Abstrak

Tujuan penelitian ini untuk mengetahui pengaruh antara Promosi dan Kualitas Produk baik secara parsial maupun secara simultan terhadap Keputusan Pembelian pada PT. Sinergia Beaute Indonesia Jakarta Pusat. Metode yang digunakan adalah metode analisis deskriptif kuantitatif. Populasi pada penelitian ini adalah konsumen PT. Sinergia Beaute Indonesia sebanyak 2.318 orang. Teknik sampling menggunakan non probability sampling dengan jenis purposive sampling. Sampel penelitian ini ditentukan menggunakan rumus Slovin yaitu sebanyak 96 responden. Uji instrumen data pada penelitian ini menggunakan uji validitas, uji reliabilitas, dan uji asumsi klasik. Teknik analisis data menggunakan uji regresi linear sederhana, uji regresi linear berganda, uji determinasi, serta uji hipotesis. Hasil dari penelitian ini menunjukkan bahwa secara parsial, promosi berpengaruh positif dan signifikan terhadap keputusan pembelian. Kualitas produk berpengaruh positif dan signifikan juga secara parsial. Promosi dan kualitas produk berpengaruh positif dan signifikan secara simultan terhadap keputusan pembelian.

Kata Kunci: Promosi, Kualitas Produk, Keputusan Pembelian
Solar System Wave Function and its Achievements
Authors: Soltani Abolfazl
Published: April 2022

Pluto, Ceres and all planets of solar system except Neptune, with a high approximation, follow a law called Titius-Bode law (TBL) or Bode law, which can by no means be considered as a stochastic event. This law shows that the distance of the planets from the sun in Solar system is regulated. Here, we prove that the existence of a standing and cosine wave packet in solar system, with the wavelength λ = 0.6 AU (AU represents the distance of earth from the sun) and the phase constant ∅0=π/6, is the reason for TBL. Moreover, we prove that this huge wave packet belongs to the sun. In the following of the article, we will enter into the atomic field and arrive to a new atomic model that helps us to describe many phenomena such as the normal Zeeman Effect and atomic and molecular bonds.
PERAMALAN PERGERAKAN INFLASI DI JAWA TIMUR DENGAN MENGGUNAKAN METODE TRIPLE EXPONENTIAL SMOOTHING
Authors: Ramadanti Alvin Nuralif , Zulfa Elok Indana , Sunariadi Noviati Maharani , Novitasari Dian C. Rini
Published: April 2022

The economic growth of a nation is strongly influenced by inflation. Inflation is the continuous soaring price of goods or services. This study aims to predict the movement of inflation that will occur in East Java from January 2021 to December 2021. This study uses 48 data from the East Java Province inflation rate data from January 2017 to December 2020 sourced from the official website of BPS East Java. Predictions using the triple exponential smoothing method with forecasting evaluation using MAPE. Based on the analysis results, the parameters used are ⍺ = 0,01, β = 0,09 dan γ = 0,30 which produces a MAPE value of 1.619%, which is classified as very good. The results show that the inflation forecasting from January 2021 to December 2021 is estimated at -0.13 to 0.48, with an average of 0.087. Thus, the movement of inflation in East Java from January 2021 to December 2021 is classified as low inflation, so it shows that prices and services are still stable.
Effective Primary Prevention of Atopic Dermatitis in High-Risk Neonates via Moisturizer Application: Protocol for a Randomized, Blinded, Parallel, Three-Group, Phase II Trial (PAF Study)
Authors: Inuzuka Yusuke , Yamamoto-Hanada Kiwako , Pak Kyongsun , Miyoshi Takekazu , Kobayashi Tohru , Ohya Yukihiro
Published: April 2022

Background

Atopic dermatitis (AD) is a chronic and inflammatory skin disease that causes health-related burdens associated with pruritus and poor quality of life. Our previous study demonstrated that moisturizer (2e) application has a primary preventive effect on AD. However, this effect was not observed in recent randomized control trials. Thus, the ideal moisturizer type and application frequency for preventing AD development in infants remains unclear. We hypothesize that twice daily application of moisturizer is more effective than once daily application. We predict that applying sufficient amounts of high-quality moisturizer may be effective for preventing AD development in neonates and infants. Here, we describe a protocol for comparing the efficacy of twice daily and once daily application of Fam's Baby™ moisturizer and once daily application of 2e moisturizer for preventing AD in neonates.

Methods

This study is a single-center, three-parallel group, assessor-blind, superiority, individually randomized, controlled, phase II trial. Sixty newborns with at least one parent or sibling who has had AD is randomly assigned to application of Fam's Baby twice daily, Fam's Baby once daily, or 2e once daily in a 1:1:1 ratio until 32 weeks old. The primary outcome is the time to the first onset of AD during administration of the moisturizer.

Discussion

This is the first phase II randomized, controlled trial in Japan to estimate how effective the twice daily or once daily application of Fam's Baby moisturizer is in preventing AD compared to the once daily application of 2e moisturizer. In this study, we will use 2e once daily as a control to confirm the efficacy for primary prevention of AD as found in our previous trial. Based on the results of this study, we hope to conduct a phase III study to determine the optimal method for preventing AD via moisturizer application. Evaluation of application of moisturizers for preventing AD in this study is expected to contribute to a reduction in the prevalence of AD and a reduction in health care costs.

Trial registration

Japan Registry of Clinical Trials (jRCT); ID: jRCTs031200070.
Rank-Based Mixture Models for Temporal Point Processes
Authors: Chen Yang , Ma Yijia , Wu Wei
Published: April 2022

Temporal point process, an important area in stochastic process, has been extensively studied in both theory and applications. The classical theory on point process focuses on time-based framework, where a conditional intensity function at each given time can fully describe the process. However, such a framework cannot directly capture important overall features/patterns in the process, for example, characterizing a center-outward rank or identifying outliers in a given sample. In this article, we propose a new, data-driven model for regular point process. Our study provides a probabilistic model using two factors: (1) the number of events in the process, and (2) the conditional distribution of these events given the number. The second factor is the key challenge. Based on the equivalent inter-event representation, we propose two frameworks on the inter-event times (IETs) to capture large variability in a given process—One is to model the IETs directly by a Dirichlet mixture, and the other is to model the isometric logratio transformed IETs by a classical Gaussian mixture. Both mixture models can be properly estimated using a Dirichlet process (for the number of components) and Expectation-Maximization algorithm (for parameters in the models). In particular, we thoroughly examine the new models on the commonly used Poisson processes. We finally demonstrate the effectiveness of the new framework using two simulations and one real experimental dataset.
MSC in Tendon and Joint Disease: The Context-Sensitive Link Between Targets and Therapeutic Mechanisms
Authors: Roth Susanne Pauline , Burk Janina , Brehm Walter , Troillet Antonia
Published: April 2022

Mesenchymal stromal cells (MSC) represent a promising treatment option for tendon disorders and joint diseases, primarily osteoarthritis. Since MSC are highly context-sensitive to their microenvironment, their therapeutic efficacy is influenced by their tissue-specific pathologically altered targets. These include not only cellular components, such as resident cells and invading immunocompetent cells, but also components of the tissue-characteristic extracellular matrix. Although numerous in vitro models have already shown potential MSC-related mechanisms of action in tendon and joint diseases, only a limited number reflect the disease-specific microenvironment and allow conclusions about well-directed MSC-based therapies for injured tendon and joint-associated tissues. In both injured tissue types, inflammatory processes play a pivotal pathophysiological role. In this context, MSC-mediated macrophage modulation seems to be an important mode of action across these tissues. Additional target cells of MSC applied in tendon and joint disorders include tenocytes, synoviocytes as well as other invading and resident immune cells. It remains of critical importance whether the context-sensitive interplay between MSC and tissue- and disease-specific targets results in an overall promotion or inhibition of the desired therapeutic effects. This review presents the authors’ viewpoint on disease-related targets of MSC therapeutically applied in tendon and joint diseases, focusing on the equine patient as valid animal model.
Nanodiamond as a Cytokine Sponge in Infectious Diseases
Authors: Yoo Wonbeak , Lee Wonhwa , Kim Hong Nam , Jeong Jiyoung , Park Hee Ho , Ahn June Hong , Jung Dana , Lee Juheon , Kim Ji-su , Lee Seung Whan , Cho Wan-Seob , Kim Seokho
Published: April 2022

Cytokine release syndrome (CRS) is a systemic inflammatory response resulting in overexpression of cytokines in serum and tissues, which leads to multiple-organ failure. Due to rapid aggravation of symptoms, timely intervention is paramount; however, current therapies are limited in their capacity to address CRS. Here, we find that the intravenous injection of highly purified detonation-synthesized nanodiamonds (DND) can act as a therapeutic agent for treating CRS by adsorbing inflammatory cytokines. Highly purified DNDs successfully inactivated various key cytokines in plasma from CRS patients with pneumonia, septic shock, and coronavirus disease 2019 pandemic (COVID-19). The intravenous injection of the DND samples in a mouse sepsis model by cecal ligation and puncture significantly improved survival rates and prevented tissue damage by reducing the circulating inflammatory cytokines. The results of this study suggest that the clinical application of highly purified DND can provide survival benefits for CRS patients by adsorbing inflammatory cytokines.
SHIP1 Activator AQX-1125 Regulates Osteogenesis and Osteoclastogenesis Through PI3K/Akt and NF-κb Signaling
Authors: Xie Xudong , Hu Liangcong , Mi Bobin , Panayi Adriana C. , Xue Hang , Hu Yiqiang , Liu Guodong , Chen Lang , Yan Chenchen , Zha Kangkang , Lin Ze , Zhou Wu , Gao Fei , Liu Guohui
Published: April 2022

With the worldwide aging population, the prevalence of osteoporosis is on the rise, particularly the number of postmenopausal women with the condition. However, the various adverse side effects associated with the currently available treatment options underscore the need to develop novel therapies. In this study, we investigated the use of AQX-1125, a novel clinical-stage activator of inositol phosphatase-1 (SHIP1), in ovariectomized (OVX) mice, identifying a protective role. We then found that the effect was likely due to increased osteogenesis and mineralization and decreased osteoclastogenesis caused by AQX-1125 in a time- and dose-dependent manner. The effect against OVX-induced bone loss was identified to be SHIP1-dependent as pretreatment of BMSCs and BMMs with SHIP1 RNAi could greatly diminish the osteoprotective effects. Furthermore, SHIP1 RNAi administration in vivo induced significant bone loss and decreased bone mass. Mechanistically, AQX-1125 upregulated the expression level and activity of SHIP1, followed upregulating the phosphorylation levels of PI3K and Akt to promote osteoblast-related gene expressions, including Alp, cbfa1, Col1a1, and osteocalcin (OCN). NF-κB signaling was also inhibited through suppression of the phosphorylation of IκBα and P65 induced by RANKL, resulting in diminished osteoclastogenesis. Taken together, our results demonstrate that AQX-1125 may be a promising candidate for preventing and treating bone loss.
The Biological Functions and Regulatory Mechanisms of Fatty Acid Binding Protein 5 in Various Diseases
Authors: Xu Binyue , Chen Lu , Zhan Yu , Marquez Karl Nelson S. , Zhuo Lvjia , Qi Shasha , Zhu Jinyu , He Ying , Chen Xudong , Zhang Hao , Shen Yingying , Chen Gongxing , Gu Jianzhong , Guo Yong , Liu Shuiping , Xie Tian
Published: April 2022

In recent years, fatty acid binding protein 5 (FABP5), also known as fatty acid transporter, has been widely researched with the help of modern genetic technology. Emerging evidence suggests its critical role in regulating lipid transport, homeostasis, and metabolism. Its involvement in the pathogenesis of various diseases such as metabolic syndrome, skin diseases, cancer, and neurological diseases is the key to understanding the true nature of the protein. This makes FABP5 be a promising component for numerous clinical applications. This review has summarized the most recent advances in the research of FABP5 in modulating cellular processes, providing an in-depth analysis of the protein’s biological properties, biological functions, and mechanisms involved in various diseases. In addition, we have discussed the possibility of using FABP5 as a new diagnostic biomarker and therapeutic target for human diseases, shedding light on challenges facing future research.
Senescence State in Mesenchymal Stem Cells at Low Passages: Implications in Clinical Use
Authors: Alves-Paiva Raquel M. , Nascimento Sabrina do , De Oliveira Denise , Coa Larissa , Alvarez Kelen , Hamerschlak Nelson , Okamoto Oswaldo Keith , Marti Luciana C. , Kondo Andrea T. , Kutner Jose Mauro , Bortolini Maria Augusta Tezelli , Castro Rodrigo , Godoy Juliana A. Preto de
Published: April 2022

Mesenchymal stem cells (MSCs) are multipotent cells found in various tissues and are easily cultivated. For use in clinical protocols, MSCs must be expanded to obtain an adequate number of cells, but a senescence state may be instituted after some passages, reducing their replicative potential. In this study, we report a case where MSC derived from an elderly donor acquired a senescence state after three passages. The bone marrow was aspirated from a female patient submitted to a cell therapy for the incontinency urinary protocol; MSCs were cultivated with DMEM low glucose, supplemented with 10% autologous serum (AS) plus 1% L-glutamine and 1% antibiotic/antimycotic. Senescence analysis was performed by β-galactosidase staining after 24 and 48 h. Controls were established using BM-MSC from healthy donors and used for senescence and gene expression assays. Gene expression was performed using RT-PCR for pluripotency genes, such as SOX2, POU5F1, NANOG, and KLF4. MSC telomere length was measured by the Southern blotting technique, and MSCs were also analyzed for their capacity to differentiate into adipocytes, chondrocytes, and osteocytes. The patient’s MSC expansion using AS displayed an early senescence state. In order to understand the role of AS in senescence, MSCs were then submitted to two different culture conditions: 1) with AS or 2) with FBS supplementation. Senescence state was assessed after 24 h, and no statistical differences were observed between the two conditions. However, patients’ cells cultured with AS displayed a higher number of senescence cells than FBS medium after 48 h (p = 0.0018). Gene expression was performed in both conditions; increased expression of KLF4 was observed in the patient’s cells in comparison to healthy controls (p = 0.0016); reduced gene expression was observed for NANOG (p = 0.0016) and SOX2 (p = 0.0014) genes. Telomere length of the patient’s cells was shorter than that of a healthy donor and that of a patient of similar age. Osteocyte differentiation seemed to be more diffuse than that of the healthy donor and that of the patient of similar age. MSCs could enter a senescence state during expansion in early passages and can impact MSC quality for clinical applications, reducing their efficacy when administered.
Dysregulated Erythroid Mg2+ Efflux in Type 2 Diabetes
Authors: Ferreira Ana , Rivera Alicia , Wohlgemuth Jay G. , Dlott Jeffrey S. , Snyder L. Michael , Alper Seth L. , Romero Jose R.
Published: April 2022

Hyperglycemia is associated with decreased Mg2+ content in red blood cells (RBC), but mechanisms remain unclear. We characterized the regulation of Mg2+ efflux by glucose in ex vivo human RBC. We observed that hemoglobin A1C (HbA1C) values correlated with Na+-dependent Mg2+ efflux (Na+/Mg2+ exchange) and inversely correlated with cellular Mg content. Treatment of cells with 50 mM D-glucose, but not with sorbitol, lowered total cellular Mg (2.2 ± 0.1 to 2.0 ± 0.1 mM, p < 0.01) and enhanced Na+/Mg2+ exchange activity [0.60 ± 0.09 to 1.12 ± 0.09 mmol/1013 cell × h (flux units, FU), p < 0.05]. In contrast, incubation with selective Src family kinase inhibitors PP2 or SU6656 reduced glucose-stimulated exchange activation (p < 0.01). Na+/Mg2+ exchange activity was also higher in RBC from individuals with type 2 diabetes (T2D, 1.19 ± 0.13 FU) than from non-diabetic individuals (0.58 ± 0.05 FU, p < 0.01). Increased Na+/Mg2+ exchange activity in RBC from T2D subjects was associated with lower intracellular Mg content. Similarly increased exchange activity was evident in RBC from the diabetic db/db mouse model as compared to its non-diabetic control (p < 0.03). Extracellular exposure of intact RBC from T2D subjects to recombinant peptidyl-N-glycosidase F (PNGase F) reduced Na+/Mg2+ exchange activity from 0.98 ± 0.14 to 0.59 ± 0.13 FU (p < 0.05) and increased baseline intracellular Mg content (1.8 ± 0.1 mM) to normal values (2.1 ± 0.1 mM, p < 0.05). These data suggest that the reduced RBC Mg content of T2D RBC reflects enhanced RBC Na+/Mg2+ exchange subject to regulation by Src family kinases and by the N-glycosylation state of one or more membrane proteins. The data extend our understanding of dysregulated RBC Mg2+ homeostasis in T2D.