bluuebunny/crossref_metadata_2025 huggingface dataset:
MANAGEMENT OF INCLUSIVE TOURISM AT THE REGIONAL LEVEL
Authors: Yakymenko-Tereshchenko Natalia , Kholodok Valentyna
Published: December 2023

The key place of inclusive tourism in the structure of the social tourism organization system is determined. Theoretical principles were defined and practical experience of management of inclusive tourism as a key direction of social and economic development of Kharkiv region was studied. The main reasons that hinder the development of inclusive tourism in the regions are: insufficient developed infrastructure of the region; lack of conditions of access to establishments of accommodation and food of tourists; lack of possibility to visit museums, historical buildings, architectural monuments; lack of information on accessible tourist places and facilities for people with disabilities; lack of qualified staff to service people with disabilities. The state, regional and territorial levels of management of inclusive tourism are defined. The focus is on the role of each level of management and the main attention is paid to the activities of regional tourism centers. The leading experience of solving problems of development of inclusive tourism in the regions was demonstrated on the example of activity and implemented projects of Kharkiv organizational and methodical center of tourism. The implemented measures was established: dissemination of information on availability of a tourist destination; determination of availability of tourist objects with the purpose of their further inclusion in routes; participation in organization and conducting annual festivals on problems of inclusion in tourism; tourist service of socially disadvantaged groups; accompanying improvement of the inclusive field. Overcoming the problems of establishment and development of inclusive tourism depends on consolidation of efforts of all participants of the tourist sphere, including in the direction of creation of unique tourist routes for persons with special needs.
DEVELOPMENT OF ECONOMIC MONITORING SYSTEMS OF BUSINESS PROCESSES OF COMMERCIALIZATION OF INTELLECTUAL PROPERTY
Authors: Shaulska Larysa , Dyuzhev Viktor , Dolyna Irina
Published: December 2023

The article shows that special attention is currently being paid to the problems of monitoring business processes of intellectual property commercialization. The nationalization of many indicators of innovative activity, the creation of national, sectoral, regional and corporate statistical databases, the determination of data sources and the methodology of their management, accounting, calculation and consumption is a priority of state policy, especially in times of crisis, when enterprises need to improve production efficiency, raise the level competitiveness and implementation of effective forms of management in production management. An important role in the implementation of this task is assigned to the monitoring of the state of the commercial potential of enterprises, since it is one of the most effective methods of diagnosing the industrial, economic and commercial activity of enterprises. Analytical materials prepared during the monitoring process help to carry out a comprehensive analysis and forecast of the company's financial condition and, thereby, to obtain a real assessment of the company's capabilities. It is substantiated that the monitoring of business processes of intellectual property commercialization is one of the most important functions of management in assessing (analyzing) the availability, placement and use of resources of an industrial enterprise. Monitoring is a mechanism for monitoring the most important current results of commercial and intellectual and innovative activities of an industrial enterprise in the conditions of constantly changing market conditions. When forming a system for monitoring business processes of commercialization of intellectual property, it is necessary to select a monitoring object for the purpose of monitoring its current and prospective state, and a monitoring entity that will directly monitor and evaluate the results. The proposed system of indicators for monitoring business processes of commercialization of intellectual property of strategic companies, which should be carried out at the state level, will allow to reduce the risk of insolvency, bankruptcy of these companies, and most importantly - the risk of a negative impact of the deterioration of the commercial and intellectual and innovative state of strategic enterprises on the country's economy as a whole. In this regard, the monitoring of business processes of commercialization of intellectual property of strategic companies will contribute to the timely detection of signs of significant deviations from normal economic development and, thereby, will provide a real opportunity for the government and the management of business structures to take the necessary measures to prevent the emergence and development of crisis situations.
RESULTS OF FORCED «UPGRADE» OF ELECTRONIC COMMERCE
Authors: Litvynenko Mariia , Miroshnik Marija
Published: December 2023

The article examines the transformation of e-commerce, which has become an integral part of the global retail system over the past five years. Challenges looming for this area of business have been identified, as consumers have become more cautious in their spending due to inflation, the effects of the war in Ukraine, supply chain disruptions and a general sense of uncertainty. It is noted that business structures, trying to survive in the existing conditions, transform into new business forms and look for new forms of product promotion. The work shows that in practice these actions are not always effective. The «upgrade» of the Prom.ua trading platform was studied in detail – the innovative ProSale catalog, which is a tool for displaying and promoting goods on Prom and whose main goal is to attract buyers and increase sales. Prom's developers are shown to have required all but industrial customers to use the CPA Model, which assumes a single sales payout rate that is the same for all products in a given category. And most importantly, the client lost influence over the frequency and priority of issuing their goods in the ProSale Catalog. According to the data of the authors' own research, it was established that the number of customers registered on the marketplace after the forced «upgrade» decreased by 6% only in June-July. Of course, this happened under the combined influence of various factors, but the study showed that changes in the promotion of goods on Prom have a significant impact on this, and customers selling on Prom experienced a sharp decrease in the number of impressions (issues in categories) in the ProSale Catalog. The situation is shown when the seller got into a circle from which it is very difficult to get out. An explanation has been provided as to why: it is the store rating that now plays an important role in issuing ProSale Catalog products for both new sellers and «advanced» sellers on the platform. Recommendations for the Prom marketplace have been developed: bring back CPS advertising and thereby create healthy competition between sellers on the platform. Expected: value for the platform – increase in profit due to the purchase of accommodation packages, increase in spending among users on advertising services; value for the seller – increased sales and a corresponding increase in profit; value for buyers – a reduction in the prices of goods and, accordingly, the opportunity to make a larger number of purchases.
DIAGNOSTICS OF THE EFFICIENCY OF ANTI-CRISIS MARKETING AT THE ENTERPRISE
Authors: Larka Ludmila
Published: December 2023

The necessity of applying the principles of anti-crisis marketing in modern conditions and diagnosing the effectiveness of its application within the concept of anti-crisis management is substantiated. The need to analyze the effectiveness of the marketing management subsystem in relation to other functional management subsystems is emphasized: production management, personnel management, financial management, innovation management. Indicators of the effectiveness of marketing activity are systematized, which are expedient to use when diagnosing the effectiveness of anti-crisis marketing at the enterprise. A form of semantic differential has been developed for evaluating the effectiveness of the implementation of anti-crisis marketing functions at the enterprise. Zones of marketing security and marketing threats are allocated in accordance with the likely results of the assessment. Correspondence of anti-crisis marketing functions to "zones" of marketing activity is determined. It is proposed to determine the effectiveness of anti-crisis marketing in three directions: the effectiveness of preventive marketing, the effectiveness of crisis marketing, and the effectiveness of post-crisis marketing. A system of indicators is proposed for evaluating the marketing stability of the enterprise within the framework of diagnosing the effectiveness of anti-crisis marketing. The block of quantitative indicators includes the level of profitability of the enterprise's marketing activities, the dynamics of changes in market share, the consumer satisfaction index, the consumer loyalty index, and the evaluation of the client's efforts. The block of quality indicators includes the speed, accuracy and timeliness of diagnosing crisis phenomena in the field of marketing, the effectiveness of using the marketing potential of the enterprise, the effectiveness of the implementation of anti-crisis marketing functions, the effectiveness of preventive marketing, the effectiveness of crisis marketing, the effectiveness of post-crisis marketing.
STUDY OF THE CURRENT STATE AND DETERMINATION OF PROSPECTS FOR THE FUNCTIONING OF TOURISM AND HOSPITALITY INDUSTRY OF UKRAINE
Authors: Strygul Larysa , Aleksandrova Viktorija , Zhadan Tetiana
Published: December 2023

The article analyzes the current state and determines the prospects for the functioning of the tourism and hospitality industry of Ukraine. It has been proven that the problem of post-war revival and development of processes in the field of tourism and hotel and restaurant business of our state is quite urgent, based on its financial, economic and social importance for the reconstruction of the economy of our country. The level of destruction experienced by the country as a whole and the field of hospitality in particular was studied. The expediency of creating a single universal mechanism for increasing the effectiveness of measures and means of countering the impact of crisis phenomena on the functioning of the hospitality industry, taking into account new challenges and prerequisites, was determined. The level of damage to infrastructure from the destruction caused by Russia's military aggression against Ukraine is analyzed. The level of taxes received by the state budget from the tourism and hospitality industry during the period of military aggression was studied. The picture of business relocation across the country as a whole and various spheres of activity, tourism business and especially the hospitality sphere is reflected. It has been proven that the sphere of hospitality and tourism functions only partially, even in those regions where there are no active hostilities. The occupancy level of hotels was studied, taking into account the specifics of the client base, price categories and services. It has been proven that culture, sports and tourism suffered significant losses as a result of military operations, not only in terms of their size in the total part of losses, but also in terms of moral value. The problems faced by the sphere of tourism and hospitality as a result of Russia's military aggression are singled out, and it is proved that they are a valid basis for determining the aspects, directions and prospects of its post-war functioning. It was concluded that an important stage of its restoration will be the formation of new concepts of memorialization of certain places in Ukraine and the creation of memory routes, which will allow to expand the existing great historical and cultural heritage of our state and increase tourist flows, taking into account the crazy interest of the entire civilized world in the Ukrainian people. The cultural sphere is a special part of the national identity, and therefore the restoration of damaged cultural institutions and objects will occupy an important place in the process of rebuilding the country in the post-war period.
INTELLECTUAL PROPERTY AS AN OBJECT OF MANAGEMENT
Authors: Maslak Mariya
Published: December 2023

The article proves that the most important component of the intellectual capital of an industrial enterprise is intellectual property. An essential condition for increasing the competitiveness of intellectual capital is the commercialization and effective management of intellectual property objects. Under the concept of intellectual property management, it is proposed to understand an integrated system of preparation and provision of different levels of management for effective planning, control and management decision-making regarding intellectual property objects. It is designed to ensure coordination, interaction and consistency of individual management elements to achieve the strategic goals of the enterprise and its effective operation. The author recommends considering the intellectual property management process as a set of a number of stages. The first stage is the process of creating an object of intellectual property, the effective implementation of which allows the enterprise to become their right holder. At the second stage, a number of actions should be taken, thanks to which the right holder will be able to protect the intangible asset from illegal encroachments. It is proposed to consider the turnover of intellectual property objects as the third stage of management. It provides for the actual monetization of intellectual property, in particular, its use in the activities of the enterprise itself. The fourth stage involves ensuring the relevance of law enforcement documents on the results of intellectual activity. The main task of management at this stage is to maintain security documents in force. The fifth stage is one of the most important stages of the management of intellectual property rights - it is the prevention and termination of violations of the company's exclusive rights and the collection of compensations and fines from violators, that is, the protection of one's intellectual property. Actions within the framework of this stage are carried out in two main directions: monitoring the use of the appropriate company's intellectual property and claim work with violators of its rights; protection of intellectual property rights in court, if such a need becomes urgent. An important stage of management is the registration of an object of intellectual property in other countries. It is important to note that during the development of the enterprise and the introduction of products to the international market, it may be necessary to obtain legal protection in accordance with the legislation of other countries. The process of alienation of the object of intellectual property can also be called a separate stage of management. These stages should not be carried out in this order at all. As a rule, this is a complex process in which the creation, registration, monetization, control and protection of rights are carried out in parallel and regularly
A Sarcoma Masquerading as a Pseudotumor After Total Hip Arthroplasty
Authors: Kayani Babar , Clarkson Paul , Ng Tony , Masri Bassam A.
Published: December 2023

Case:

There is an increasing emphasis on adverse reactions to metal debris around prosthetic hip implants. We present a case report of a patient with increasing pain around a previous total hip arthroplasty and magnetic resonance imaging findings consistent with a pseudotumor. Serum metal ion levels were not elevated and initial biopsy findings inconclusive. The patient was diagnosed with an extraskeletal chondrosarcoma after revision total hip arthroplasty and subsequently underwent external hemipelvectomy with negative margins.

Conclusion:

This report highlights the importance of remaining vigilant for malignant sarcomas presenting as pseudotumors around hip replacements, particularly in the absence of abnormal metal ion levels or definitive biopsy results.
Treatment of Glenoid Wear with the Use of Augmented Glenoid Components in Total Shoulder Arthroplasty
Authors: Contreras Erik S. , Kingery Matthew T. , Zuckerman Joseph D. , Virk Mandeep S.
Published: December 2023

» Treatment of glenoid bone loss continues to be a challenge in total shoulder arthroplasty (TSA). Although correcting glenoid wear to patient's native anatomy is desirable in TSA, there is lack of consensus regarding how much glenoid wear correction is acceptable and necessary in both anatomic and reverse TSA.

» Use of augmented glenoid components is a relatively new treatment strategy for addressing moderate-to-severe glenoid wear in TSA. Augmented glenoid components allow for predictable and easy correction of glenoid wear in the coronal and/or axial planes while at the same time maximizing implant seating, improving rotator cuff biomechanics, and preserving glenoid bone stock because of off-axis glenoid reaming.

» Augmented glenoid components have distinct advantages over glenoid bone grafting. Glenoid bone grafting is technically demanding, adds to the surgical time, and carries a risk of nonunion and graft resorption with subsequent failure of the glenoid component.

» The use of augmented glenoid components in TSA is steadily increasing with easy availability of computed tomography–based preoperative planning software and guidance technology (patient-specific instrumentation and computer navigation).

» Although different augment designs (full wedge, half wedge, and step cut) are available and a particular design may provide advantages in specific glenoid wear patterns to minimize bone removal (i.e. a half wedge in B2 glenoids), there is no evidence to demonstrate the superiority of 1 design over others.
One Village, One Family: Social Cohesion in Rural Slovakia
Authors: Uhrin Michal , Horák Miroslav
Published: December 2023

This article is focused on mechanisms associated with social cohesion of Roman-Catholics in rural Slovakia. The article presents an analysis of ethnographic data gathered during field research in a municipality situated in White Carpathian mountains from June 2017 to July 2019. The data was collected from 38 residents of the selected denomination during semi-structured interviews. The primary aim of the article is to identify factors that help maintain social cohesion and factors that cause its disruption in concrete rural community in Slovakia. The data analysis based on the Grounded Theory method was performed in Atlas.ti. It showed that it is the help of friends, family, and neighbours, as well as family gatherings, religious tolerance, and baptism that contribute to the maintenance of social cohesion. The social cohesion is distorted by divorces, mobility of local inhabitants, ongoing industrialization, consumerism, and transformation of traditions.
Precious Metals in the Holocene Sediments of the Chukchi Sea
Authors: Astakhova N.V. , Kolesnik O.N. , Astakhov A.S. , Shi X. , Hu L. , Alatortsev A.V.
Published: December 2023

––We studied the distribution of gold, silver, and platinum group elements (Pd, Pt, Rh, Ir, and Ru) in two bottom sediment cores of the southern Chukchi Sea. It is shown that the Holocene pelite–silty sediments with an age of up to 4.0 ka BP are significantly enriched in these elements, except for Ru and Rh, relative to their clarkes. Native silver minerals were found in all samples by probe microanalysis, whereas gold minerals were revealed only in the surface layer of the sediment core closest to the Chukchi Sea coast. Multicomponent statistical analysis of the chemical composition and grain size of the sediments and the content of organic matter in them has led to the conclusion about the accumulation of clastogenic and chemogenic forms of precious metals. The abnormally high content of gold (0.3 ppm) in the recent sediments near the Chukchi Peninsula coast might be due to its additional removal from the continent as a result of the placer mining there.
Digital Transformation of Bank Syariah Indonesia Services and Its Impact on Financial Inclusion
Authors: Abdulloh Muhamad
Published: December 2023

Islamic financial inclusion is the openness of providing access and use of a variety of convenient and affordable financial services by sharia. In supporting the realization of the Sharia financial inclusion target and the Indonesian Sharia Banking Development Roadmap (RPSI) for 2020-2025, Bank Syariah Indonesia strives for customer convenience and comfort by providing access to various products and services digitally. The research method uses a type of qualitative descriptive research with a library research method. The types of data used are primary data and secondary, primary data obtained from BSI's official website and result reports, secondary data obtained from other people's research, documentation data, and studies relevant to this study. The purpose of the study was to determine 1) the level of financial literacy index and Islamic financial inclusion index in Indonesia. 2) to recognize Bank Syariah Indonesia's efforts in seeking Sharia financial inclusion targets and the Indonesian Sharia Banking Development Roadmap (RPSI) for 2020-2025. The results showed that the level of Islamic financial literacy and inclusion index in 2022 increased to 9.14% and 12.12% from the previous 8.93% and 9.10%
Synthesized Innovative Graphite with Nanostructure and Unique Properties. Increases Energy and Power of Lithium Batteries
Authors: Shembel Elena , Pustovalov Yuri , Kaszuba David , Polishchuk Yuliya , Redko Vlad , Pastushkin Timothy , Sknar Yuriy , Markevich Aleksander , Sknar Irina , Zaderey Nelya , Sagirov Igor
Published: December 2023

Nanostructured graphite –INT are developed and manufactured by INT Sp. z o.o Company, Poland. Hereinafter referred to as nanographite-INT. These powders have unique properties to organize and modify the structure of anode and cathode without binder, and catalytic properties of lithium battery electrodes. Nanographite-INT have a special set of properties, which fundamentally differ from all materials known to us of this class. Therefore are the basis of the next generation of batteries, fuel cells, solar cells and other application. Technologies of for the synthesis of nanostructured carbon materials include: isolation of the required fraction of the initial carbon material, oxidative treatment of synthesized graphite, heat treatment, mechanical processing, separation into fractions, additional mechanical processing, additional heat treatment, mixing of various fractions. The synthesis has been developed and the industrial production of unique nanographites INT was organized.
Retinal vasculature changes after 0.125% atropine treatment in children with myopia measured using OCT angiography
Authors: Liu Chun-Fu , Huang Yao-Chi , Chuang Lan-Hsin , Yeung Ling , Chen Hung-Chi , Tsai Tsung- Hsien , Chang Po-Chun , Hwang Yih-Shiou , Wu Wei-Chi , Lai Chi-Chun
Published: December 2023

BACKGROUND/OBJECTIVES: The study assessed the microvascular changes in the retina after the use of 0.125% atropine in children with myopia and the association between retina microvascular changes and the effects of myopia treatment.
PATIENTS/METHODS: In this prospective cohort study, children with myopia aged 5–18 years were given 0.125% atropine for myopia control. Retina microvascular parameters were measured during the follow-up and included vessel density of the superficial vascular plexus (SVP) and deep vascular plexus. The effect of 0.125% atropine on the change in the retina microvasculature was analysed using a linear mixed model. Pearson’s correlational analysis was used to examine the relationship between the change in axial length (AL) and microvascular changes.
RESULTS: A total of 64 eyes of 36 patients were included. A significant decrease in parafoveal vessel density of the SVP was observed in the first 3 months (p = 0.032). The change in parafoveal vessel density of the SVP in the first 3 months correlated negatively with the change in the AL after 1 year (r = –0.430, p = 0.028).
CONCLUSIONS: These results suggest that 0.125% atropine may induce changes in the retina vasculature in children with myopia and that these changes may be a potential predictor of myopia progression.
Protein production dynamics and physiological adaptation of recombinant Komagataella phaffii at near-zero growth rates
Authors: Corinna Rebnegger , Coltman Benjamin L. , Kowarz Viktoria , Peña David A. , Mentler Axel , Troyer Christina , Hann Stephan , Schöny Harald , Koellensperger Gunda , Mattanovich Diethard , Gasser Brigitte
Published: December 2023

Background
Specific productivity (qP) in yeast correlates with growth, typically peaking at intermediate or maximum specific growth rates (µ). Understanding the factors limiting productivity at extremely low µ might reveal decoupling strategies, but knowledge of production dynamics and physiology in such conditions is scarce. Retentostats, a type of continuous cultivation, enable the well-controlled transition to near-zero µ through the combined retention of biomass and limited substrate supply. Recombinant Komagataella phaffii (syn Pichia pastoris) secreting a bivalent single domain antibody (VHH) was cultivated in aerobic, glucose-limited retentostats to investigate recombinant protein production dynamics and broaden our understanding of relevant physiological adaptations at near-zero growth conditions.
Results
By the end of retentostat cultivation, doubling times of approx. two months were reached, corresponding to µ = 0.00046 h− 1. Despite these extremely slow growth rates, the proportion of viable cells remained high, and de novo synthesis and secretion of the VHH were observed. The average qP at the end of the retentostat was estimated at 0.019 mg g− 1 h− 1. Transcriptomics indicated that genes involved in protein biosynthesis were only moderately downregulated towards zero growth, while secretory pathway genes were mostly regulated in a manner seemingly detrimental to protein secretion. Adaptation to near-zero growth conditions of recombinant K. phaffii resulted in significant changes in the total protein, RNA, DNA and lipid content, and lipidomics revealed a complex adaptation pattern regarding the lipid class composition. The higher abundance of storage lipids as well as storage carbohydrates indicates that the cells are preparing for long-term survival.
Conclusions
In conclusion, retentostat cultivation proved to be a valuable tool to identify potential engineering targets to decouple growth and protein production and gain important insights into the physiological adaptation of K. phaffii to near-zero growth conditions.
Monte Carlo Markov Chain and General Orthogonal Regression to Investigate the Relationship of Earthquake Magnitudes
Authors: Firoozeh Zahra , Taran Somayeh , Asaadi Nazila , Safari Hossein
Published: December 2023

Due to the saturation of the body (mb) and surface (MS ) earthquake magnitudes, the moment magnitude (MW ) is a more convenient parameter for representing earthquake energies. We use the HRVD including 12015 earthquakes recorded from 1976 January 1 to 2001 December 31 for five regions on the Earth (Middle East-Oceania, Europe, Africa, North America, and South America), to
investigate the relationship between the body-Wave (4.6 ≤ mb ≤ 7.4), surface-Wave (2.4 ≤ MS ≤ 8.3), and moment magnitudes (4.8 ≤ MW ≤ 8.4) via Monte Carlo Markov chain (MCMC). Applying the MCMC approach, we obtain a linear relationship between mb and MW magnitudes with slopes slightly varying in the range of 0.89 to 11.02 for five regions. Also, we find a linear dependency of MW and MS with a slope ranging from 0.63 to 0.69 for the areas. We also use parameters of the linear relations of the magnitudes and the general orthogonal
regression(gor) method to estimate magnitudes’ upper and lower limits of error magnitudes.
Keywords: magnitude, earthquake, body-Wave, surface-Wave, moment magnitude
Improvement of Radiation Oncology Standardized Residency Training Systems in Different Hospital Settings
Authors: Xiaohua Wu , Hui Li , Yang Yu , Xinyi Huang , Nanxi Hu , Xueqing Zhang , Chao Li , Jinluan Li
Published: December 2023

This research investigates the evaluation of radiation oncology standardized residency training (SRT) residents regarding the final examinations and training process in different types of hospitals (cancer and general) in Fujian Province between 2021 and 2023. This study explored strategies for improving the quality of SRT. Questionnaires administered to residents participating in the final training examination for radiation oncology residents in 2021 and 2023 were thoroughly analyzed. The results show that residents from general hospitals were less satisfied with theoretical and hands-on teaching than residents in cancer hospitals in 2023 (P<0.05). Compared with 2021, 2023 residents believed the exams were more difficult and conformed less to training (P<0.05). Nevertheless, there were no significant differences in the evaluations of teaching quality or hands-on opportunities. Teachers’ qualifications for SRT, especially in general hospitals, should be further enhanced to guarantee homogenization and training quality. Offline teaching should be prioritized as indispensable, whereas online teaching can serve as a supplementary method to support resident learning.
Integrative Single-Cell Analysis: Dissecting CD8+ Memory Cell Roles in LUAD and COVID-19 via eQTLs and Mendelian Randomization
Authors: Wu Jintao , Mao Xiaocheng , Liu Xiaohua , Mao Junying , Yang Xianxin , zhou Xiangwu , Tianzhu Lu , Ji Yulong , Li Zhao , Xu Huijuan
Published: December 2023

Lung adenocarcinoma exhibits high incidence and mortality rates, presenting a significant health concern. Concurrently, the COVID-19 pandemic has emerged as a grave global public health challenge. Existing literature suggests that T cells, pivotal components of cellular immunity, are integral to both antiviral and antitumor responses. Yet, the nuanced alterations and consequent functions of T cells across diverse disease states have not been comprehensively elucidated.We gathered transcriptomic data of peripheral blood mononuclear cells from lung adenocarcinoma patients, COVID-19 patients, and healthy controls. We followed a standardized analytical approach for quality assurance, batch effect adjustments, and preliminary data processing. We discerned distinct T cell subsets and conducted differential gene expression analysis. Potential key genes and pathways were inferred from GO and Pathway enrichment analyses. Additionally, we implemented Mendelian randomization to probe the potential links between pivotal genes and lung adenocarcinoma susceptibility.Our findings underscored a notable reduction in mature CD8+ central memory T cells in both lung adenocarcinoma and COVID-19 cohorts relative to the control group. Notably, the downregulation of specific genes, such as TRGV9, could impede the immunological efficacy of CD8+ T cells. Comprehensive multi-omics assessment highlighted genetic aberrations in genes, including TRGV9, correlating with heightened lung adenocarcinoma risk.Through rigorous single-cell transcriptomic analyses, this investigation meticulously delineated variations in T cell subsets across different pathological states and extrapolated key regulatory genes via an integrated multi-omics approach, establishing a robust groundwork for future functional inquiries. This study furnishes valuable perspectives into the etiology of multifaceted diseases and augments the progression of precision medicine.
Auto-ICell: An Automated and Cost-Effective Integrated Droplet Microfluidic Platform for Real-Time Analysis of Single-Cell Morphology and Apoptosis
Authors: Wei Yuanyuan , Lin Meiai , Luo Shanhang , Abbasi Syed Muhammad Tariq , Tan Liwei , Cheng Guangyao , Bai Bijie , Ho Yi-Ping , Yuan Wu , Ho Ho-Pui
Published: December 2023

Existing single-cell analysis methods based on droplet microfluidics face challenges related to high chip costs and the lack of accurate, time-efficient, and high-throughput analysis techniques. To address these limitations, we present the Auto-ICell, a cost-effective droplet microfluidic system that integrates a 3D-printed microfluidic chip with automated image analysis algorithms. The Auto-ICell enables the generation of uniform droplet reactors and real-time analysis of single-cell morphology and apoptosis. With a throughput of 1,500 droplets per minute and droplet diameters ranging from 70 to 240 μm, the system employs colour-based and deep-learning-enabled algorithms for the analysis of droplet encapsulation and cell morphology, respectively. The Auto-ICell achieves an accuracy of over 91% and processes images in less than 0.03 seconds, eliminating the need for specialized facilities or trained operators. Its versatility extends to applications in cell culture, microreactors, drug carriers, assays, synthetic biology, and diagnostics. This study showcases the potential of the Auto-ICell system in advancing biological research and personalized disease treatment.
Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging
Authors: Yamada Hidetada , Toko Megumi , Nakamori Masahiro , Ueno Hiroki , Aoki Shiro , Sugimoto Tomohiro , Yasutomi Hiroko , Nakamichi Kazuo , Maruyama Hirofumi
Published: December 2023

Progressive multifocal leukoencephalopathy (PML) rarely occurs in patients with systemic lupus erythematosus (SLE). This report presents a patient who developed PML due to SLE-associated lymphocytopenia. A 60-year-old woman diagnosed with SLE undergoing multiple immunosuppressive therapies, including azathioprine, presented with cerebral cortical symptoms, lymphocytopenia, and vitamin B12 deficiency and was subsequently diagnosed with SLE-associated PML. We evaluated the cause and disease activity of PML, focusing on the longitudinal assessment of lymphocytopenia, JC virus (JCV) DNA copy number in the cerebrospinal fluid, and magnetic resonance imaging (MRI) findings. Immunosuppressive therapy contributes to lymphocytopenia and PML; discontinuing azathioprine and initiating alternative immunosuppressive treatments (with intramuscular vitamin B12 injections) affected lymphocytopenia and disease management. The large hyperintense and punctate lesions observed on the fluid-attenuated inversion recovery images exhibited varying behaviors, indicating fluctuating PML disease activity. In addition, prominent hypointense signal rims were evident on susceptibility-weighted imaging during the late stages, particularly when JCV DNA copies were low. Clinicians should be meticulous when assessing the underlying pathology of lymphocytopenia owing to the multifactorial causes of PML due to SLE. This case’s time-dependent changes in lymphocytopenia, JCV DNA copy number, and MRI findings could provide clinicians with valuable assessment support.
Ocean Tides on Planets Orbiting Low-mass Stars
Authors: Yang Jun , Shi Jiaru , Abbot Dorian , LIU Yonggang , Kang Wanying , Lin Yufeng , Hu Yongyun
Published: December 2023

Planets in the liquid-water habitable zone of low-mass stars experience large tidal forces, 103 to 104 times those on Earth, due to the small distance between the habitable zone and the host star. Here, for the first time, we perform global ocean tide simulations and show that ocean tides on the planets with large eccentricities can reach 100-1000 m in height and ~10 m s-1 in flow speed. Interactions between tide and bottom topography can induce large energy dissipation, 10-100 W m-2 in global mean. This tidal energy dissipation can strongly accelerate orbital evolution by 1-2 orders, from ~1010 to 109 or 108 Earth years. Through global climate simulations, we further show that this level of tidal dissipation can strongly warm the surface, melt sea ice, and even push the system into a catastrophic runaway greenhouse state, within which the existence of life is impossible. For planets with small eccentricities, the ocean tides are much weaker.
Psychological impact of acne and post inflammatory hyperpigmentation among Sudanese women
Authors: Abdelgadir Hiba Salah , Abdelgadir Hind Salah , Ahmed Mosab Abdelgadir
Published: December 2023

Background:
Acne vulgaris is a chronic inflammatory disorder of the skin which often causes a negative impact on a woman's psychological state and quality of life. This study seeks to provide basic data and information about the psychological impact of acne on Sudanese women.
Materials and methods:
A cross-sectional questionnaire-based study was conducted during the period from June 2022 to January 2023. A total of 400 females aged 15 years and above were included in this study. These are Sudanese women who had suffered from acne in their lives, and who responded to the online study questionnaire. Cardiff Acne Disability Index (CADI) was used to assess the psychological effect of acne.
Results:
Seventy one percent of respondents had active acne. Acne scars were observed in (74.8%) of participants, while post-acne hyperpigmentation was observed in (71.3%). Facial acne was the most common, as it was observed in (75.8%) of the respondents. The mean age at acne onset was 15.66 years and ranged between 10 and 36 years. Mild and moderate acne were the most common types, accounting for (37.0%) and (41.5%) of cases, respectively. Acne was found to affect the psychological state of the vast majority of the respondents (89%). Cosmetics or makeup were used by (42.3%) of the respondents to conceal acne and scars. Late onset of acne treatment was reported in (42%) of the cases. Most respondents (72.5%) visited doctors to treat acne. The mean Cardiff Acne Disability Index (CADI) score was 4.55, which reflects mild effects of acne on the quality of life of most of the respondents.
The adverse psychological impact was found to be significantly associated with increased acne severity, scarring, and hyperpigmentation as well as with university educated respondents.
Conclusion:
It was found that acne has mild effects on the quality of life of Sudanese women. Late onset of acne treatment resulted in widespread scarring and post-inflammatory hyperpigmentation in most participants, which was associated with the psychological impact of acne. There is an urgent need to encourage early treatment of acne to reduce the physical sequalae of acne to reduce the psychosocial consequences associated with the disease and the risk of scarring and hyperpigmentation on Sudanese women. Sudanese health authorities and Sudanese doctors can address this issue through education and awareness programs.
Effect of pretreatment with a small dose of esketamine on sufentanil-induced cough during anesthesia induction: A randomized controlled trial
Authors: GAO Liangliang , Zhang Zhuoliang , Zhu Yi , Lu Xinyu , Tian Yue , Wei Lei
Published: December 2023

Background
Sufentanil-induced cough is common during the induction of anesthesia. The objective of this study was to determine whether pretreatment with a small dose of esketamine is effective in treating sufentanil-induced cough.
Methods
220 patients were screened, and 200 patients who had scheduled elective surgery and were between 18 and 70 years old were randomly divided into two groups. Before sufentanil was administered, group K was injected with 0.15 mg/kg esketamine at 5 s, and group C was administered with the same volume. Within 1 minute after sufentanil(0.4ug/kg) injection during induction, cough incidence and severity were evaluated. After sufentanil was injected, we recorded its hemodynamic changes and side effects.
Results
In the group K and group C, there was an incidence of cough of 5 and 34%, respectively. The K group had a significantly lower incidence and severity of cough compared to the C group immediately after sufentanil injection (P < 0.05). MAP and HR did not differ significantly between the two groups during three different times of general anesthesia induction (P > 0.05).
Conclusion
In our study, we found that sufentanil-induced cough was significantly reduced by pretreatment with 0.15mg/kg esketamine, but with no significant changes in the hemodynamic status.
Trial registration:
Chinese Clinical Trial Registry (ChiCTR2200063821, registered date: 17/09/2022), http://www.chictr.org.cn
Stable Isotopes as a Predictor for Organic or Conventional Classification of Berries and Vegetables
Authors: Zhu-Barker Xia
Published: December 2023

As organic agriculture spreads globally, promising enhanced food quality and soil health, the challenge lies in verifying the authenticity of organic practices, notably in developing countries with limited oversight. This study offers a solution by examining the elemental composition of carbon (C) and nitrogen (N), particularly their stable isotopes (δ13C and δ15N), in seven crops grown under organic or conventional methods across various countries. Our findings reveal that, while total C and N content showed no significant differences across production methods or regions, the N stable isotope (δ15N) levels were markedly distinct between organic and conventional crops. This difference allows us to propose a δ15N threshold to reliably distinguish between organic and conventional raspberries and strawberries, with a very low error rate. These thresholds, backed by an extensive dataset (n = 791), hold promise as effective tools for confirming organic authenticity, providing a new standard for future validation of organic farming practices.
Orbital-scale Dynamics of the Eastern Asian Summer Monsoon
Authors: Sinha Nitesh , Timmermann Axel , Lee Sun-Seon , Jo Kyoung-Nam , Wassenburg Jasper , Cleary Daniel , Yun Kyung-Sook
Published: December 2023

Due to multiple factors influencing orbital-scale variability of the East Asian Summer monsoon (EASM), the interpretation of speleothem-based climate reconstructions from this region has remained challenging. Using a 130,000-year accelerated astronomically-forced simulation conducted with the isotope-enabled Community Earth System Model, we determine the drivers of orbital-scale EASM variability in oxygen isotopes (δ18O). Indian summer monsoon (ISM) and associated moisture transport changes control the strong precipitation-δ18O variability in the western part of the EASM domain on timescales of 21,000 years. In the eastern part of the EASM region, including Korea and Japan, the interactions between ISM, western North Pacific Subtropical High, and westerlies control precipitation-δ18O. Thus, precessional variability in precipitation-δ18O is suppressed by the compensating effects of oceanic and continental moisture sources.
The influence of dual filial piety consciousness on mental health in Chinese youths is moderated by mobility and mediated by bidirectional intergenerational support
Authors: Zhou Jingjing , Zhao Qian , Zhang Huahua
Published: December 2023

Background: Previous studies have found the influence on mental health by filial piety (FP) among young people; however, there has been a lack of attention to the interactions between their dual FP (authoritarian vs. reciprocal) consciousness, bidirectional intergenerational support, and mental health. In the Chinese context, it is also unclear whether these interactions vary according to youth mobility (local vs. migrant). This study therefore explored the triple interactions between dual FP consciousness, bidirectional intergenerational support, and mental health in young people, and studied the mediating effect of bidirectional intergenerational support and the moderating effect of youth mobility therein.
Methods: Using the 2017 Chinese General Social Survey statistics, we defined young people as those aged 15-44 years. The final effective sample consisted of 1,400 individuals. Software SPSS v22.0 was used to organize the data and to conduct descriptive and correlation analyses, and SPSS PROCESS Macro v3.4.1 to test the mediating and moderating effects.
Results: With such variables as gender, age, ethnicity, education level, marital status, household registration type, personal annual income, and number of children controlled, we found that young people’s dual FP (authoritarian vs. reciprocal) consciousness and mental health were positively correlated (r = 0.281, p < 0.01; r = 0.406, p < 0.01, respectively). Higher dual FP consciousness corresponded to better mental health, and the influence of dual FP consciousness on mental health was mediated by bidirectional intergenerational support and moderated by mobility.
Conclusions: Our findings provide theoretical insights and practical pointers for improving the youth mental health. First, theoretical propaganda and practical activities should be combined to strengthen the publicity of the filial culture. Second, the role of family members should be given full play, because intergenerational mutual support helps maximize the interests of the family as a whole. Finally, young migrants should be guided vigorously to participate in community activities themed on “FP and respect for the elderly” to improve their FP consciousness. By forging harmonious intergenerational relationships, their mental health can be expected to improve.
WITHDRAWN: A Meta-Heuristic Based Approach for Optimal Fake News Detection Using Supervised Learning
Authors: Jaiswal Arunima , Verma Himika , Sachdeva Nitin , Wary Alongbar , Indra Gaurav , Brahma Daniel Kr.
Published: December 2023

The rapid dissemination of fake news in the digital age has raised concernsregarding the authenticity and credibility of online information. In this study, we propose an innovative approach for detecting fake news by combining the power of RoBERTa, a state-of-the-art language model, with the Firefly Optimization Algorithm (FOA) and Long Short-Term Memory (LSTM) neural networks. Our model leverages RoBERTa’s contextual understanding of text to extract informative features from news articles, including content, user engagement, and source characteristics. The FOA is employed to optimize the selection of these features, enhancing the model’s ability to discern between genuine and deceptive news. The selected features are then used as inputs to an LSTM network, which learns the temporal dependencies within the data for accurate classification. To validate the effectiveness of our approach, we conduct experiments using benchmark datasets such as ISOT and fakenewsnet specifically designed for fake news detection tasks. The experimental results demonstrate that our proposed model outperforms existing methods in terms of accuracy and other performance metrics. By integrating RoBERTa, FOA, and LSTM, our model effectively combines contextual understanding, feature selection optimization, and sequence modeling, enabling accurate identification of fake news articles. This research contributes to the advancement of fake news detection techniques and offers a promising solution to address the challenges associated with online misinformation, ultimately fostering trust and reliability in the digital information landscape.