bluuebunny/crossref_metadata_2025 huggingface dataset:
Representaciones y estereotipos de la masculinidad en el cine boliviano contemporáneo
Authors: Virguetti Pablo
Published: December 2023

En este trabajo planteo el análisis de los diversos discursos e imaginarios de la masculinidad que aparecen en el cine boliviano contemporáneo. De manera más particular, mi estudio se centra en las películas Dependencia sexual de Rodrigo Bellot y Zona Sur de Juan Carlos Valdivia. Se presta una atención preponderante a la forma dominante de las expresiones de la masculinidad, es decir la virilidad, entendida como un constructo social que fuerza al hombre a demostrar constantemente su poder. Sin embargo, el estudio también subraya las formas en las que se pueden presentar otras versiones de la masculinidad y sus problemáticas. Finalmente, se busca tener una visión estructural de los imaginarios de la masculinidad como herramienta determinante en las negociaciones del contrato social.
Statistical Methods for Predicting of the Quality of Aluminum Ingots
Authors: Tschimpke Marco Johannes , Gerber Alexander , Neubert Steffen , Schreyer Manuela , Trutschnig Wolfgang
Published: December 2023

In recent years, methods from Data Science and Artificial Intelligence have become more and more important in various fields of economy and everyday life. Those methods are, for instance, used in context of driving assistance systems or queries in search engines. Our current works aims at developing and/or improving methods from statistics and machine learning to select relevant features concerning the product quality of aluminum ingots. During the production of aluminum, numerous process signals, such as temperature curves, are recorded. To quantify the dependency of the ingot-quality on different signals, existing statistical methods need to be adjusted and extended to the timeseries setting. The first problem tackled is the definition of a criterion numerically describing the quality of the ingots and therefore allowing to compare ingots with respect to their quality (independent of the final format of the product). A second, nontrivial challenge is to detect those process signals relevant for the ingot quality and account for possible interrelations. Our contribution sketches how timeseries information can be aggregated/discretisized and describes various candidate approaches for features selection.
Sustainability and Life Cycle Analysis of 3D Printing Industries
Authors: Tay Yi Wei Daniel , Tan Ming Jen
Published: December 2023

There has been a lot of interest in the sustainability aspects of 3D Printing, also known as Additive Manufacturing, due to its potential for resource conservation, localized production, and optimized and adaptive designs. However, quantifying these sustainability advantages has proven to be a challenging task. Several tools have been developed to address this endeavor, and this article provides an overview of some of these tools, focusing on their application in the Manufacturing and Building & Construction sectors. The most widely adopted studies are Life Cycle Assessments (LCAs), which help us understand the environmental impact through all stages of a product’s life, and are key to identifying best practices and opportunities for innovation. By exploring the sustainability dimensions of 3D printing through the lens of life cycle analysis, this article aims to shed light on the crucial role that LCAs play in assessing the environmental implications of 3D printing practices. Furthermore, it underscores the importance of leveraging this knowledge to drive sustainable practices, improve the efficiency of the 3D printing industry, and pave the way for a more sustainable future.
The UAF1–USP1 Deubiquitinase Complex Stabilizes cGAS and Facilitates Antiviral Responses
Authors: Yu Zhongxia , Tong Li , Ma Chenkai , Song Hui , Wang Jie , Chai Li , Wang Caiwei , Wang Mengge , Wang Chunying , Yan Rongzhen , Fu Yue , Jia Mutian , Zhao Wei , Zhao Chunyuan
Published: December 2023

Cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS) detects cytoplasmic microbial DNA and self-DNA from genomic instability, initiates innate immunity, and plays fundamental roles in defense against viruses and the development of various diseases. The cellular cGAS level determines the magnitude of the response to DNA. However, the underlying mechanisms of the control of cGAS stability, especially its feedback regulation during viral infection, remain largely unknown. In this study, we show that viral infection induces the expression of the UAF1–USP1 deubiquitinase complex in primary peritoneal macrophages (PMs) of C57BL/6J mice. UAF1–USP interacts with cGAS, selectively cleaves its K48-linked polyubiquitination, and thus stabilizes its protein expression in PMs and HEK293T cells. Concordantly, the UAF1–USP1 deubiquitinase complex enhances cGAS-dependent type I IFN responses in PMs. Uaf1 deficiency and ML323 (a specific inhibitor of UAF1–USP1 deubiquitinase complex) attenuates cGAS-triggered antiviral responses and facilitates viral replication both in vitro and in vivo. Thus, our study uncovers a positive feedback mechanism of cGAS-dependent antiviral responses and suggests the UAF1–USP1 complex as a potential target for the treatment of diseases caused by aberrant cGAS activation.
Mouse Trophoblast Cells Have Attenuated Responses to TNF-α and IFN-γ and Can Avoid Synergic Cytotoxicity of the Two Cytokines
Authors: Fendereski Mona , Ming Hao , Jiang Zongliang , Guo Yan-Lin
Published: December 2023

TNF-α and IFN-γ are two inflammatory cytokines that play critical roles in immune responses, but they can also negatively affect cell proliferation and viability. In particular, the combination of the two cytokines (TNF-α/IFN-γ) synergistically causes cytotoxicity in many cell types. We recently reported that mouse embryonic stem cells (ESCs) isolated from the blastocyst stage embryo do not respond to TNF-α and have limited response to IFN-γ, thereby avoiding TNF-α/IFN-γ cytotoxicity. The current study expanded our investigation to mouse trophoblast stem cells (TSCs) and their differentiated trophoblasts (TSC-TBs), the precursors and the differentiated cells of the placenta, respectively. In this study, we report that the combination of TNF-α/IFN-γ does not show the cytotoxicity to TSCs and TSC-TBs that otherwise effectively kills fibroblasts, similar to ESCs. Although ESCs, TSCs, and TSC-TBs are dramatically different in their growth rate, morphology, and physiological functions, they nevertheless share a similarity in being able to avoid TNF-α/IFN-γ cytotoxicity. We propose that this unique immune property may serve as a protective mechanism that limits cytokine cytotoxicity in the blastocyst. With molecular and cellular approaches and genome-wide transcriptomic analysis, we have demonstrated that the attenuated NF-κB and STAT1 transcription activation is a limiting factor that restricts the effect of TNF-α/IFN-γ on TSCs and TSC-TBs.
Ayurvedic management of Bipolar affective disorder: A case report
Authors: Thasni M. , Madhavan Jithesh , Aparna P. M.
Published: December 2023

Bipolar Affective Disorder (BPAD) is a recurrent and chronic disorder that is characterized by episodes of depression and elevated mood with intervening periods of normal mood. This disorder is associated with severely debilitating symptoms that hamper the quality of life of both patients and their caregivers as well. Bipolar disorder typically begins in adolescence or early adulthood and can have life-long adverse effects on the patient's mental and physical health, educational and occupational functioning, and also on interpersonal relationships. A 25-year-old female presented with primary concerns of frequent speech which was occasionally incoherent, elevated mood, wandering nature, increased social mingling, increased thoughts, increased anger, irritable nature and feeling that her mother is the “devil,” and thoughts of killing her repeatedly coming to her mind for six months. A detailed interview with her parents revealed the presence of similar symptoms and irritable nature most of the time. The observations were made in the level of affective and behavioral domains of BPAD I. In Ayurveda, the condition was diagnosed as Vatikonmada (~Vata predominant insanity) with Pittanubandha (~association of Pitta) based on the clinical symptoms. Shodhana (~purificatory therapies)-based treatment protocols including Virechana (~therapeutic purgation), Snehapana (~internal oleation), Vamana (~therapeutic emesis), Basti (~enema), and Nasya (~medication through nose) followed by Shamana (~palliative procedure) were planned and administered. Psychological supportive measures such as Satvavajaya (~psychotherapy) and Yoga therapy were also sought under the supervision of Manasa roga (~psychiatric disorder) experts and qualified yoga therapists, and the mental status of the patient was assessed using the Young Mania Rating Scale. The case showed considerable relief after the treatment with Shodhana and Shamana based therapies and the psychological supportive measures.
Ayurvedic management of Ekakushtha (Psoriasis): A case study
Authors: Yadav Ragini , Mishra Angkita , Yadav Vijay Singh , Sahu Girwar , Mandal Sisir Kumar
Published: December 2023

Ekakushtha, comparable to psoriasis, is a non-infectious, autoimmune, chronic inflammatory disease of the skin characterized by well-defined erythematous plaques with silvery scale occurring mainly on the extensor surface, scalp, and having a chronic course. It is relapsing in nature. It affects not only the physical state of the patient but also impacts mental and social life of the patient. A 17-year-old male patient presented to the Ayurveda outpatient department with complaints of itchy scaly lesions on the head, chest, abdomen, back, and bilateral upper and lower limbs from the past five years. He was diagnosed with Ekakushtha and Shamana chikitsa (~palliative procedures) was planned in the management. The Psoriasis Area Severity Index (PASI) score was used to assess the outcome. The PASI score has decreased from 21.8 to 0.8. The present case report illustrates the significance of Ayurvedic treatment in the management of Ekakushtha, and the outcome infers that chronic, non-communicable, auto-immune diseases can be managed with Ayurveda approaches successfully.
Comparative analysis of performance of AutoML algorithms: Classification model of payment arrears in students of a private university
Authors: Villarreal-Torres Henry , Ángeles-Morales Julio , Cano-Mejía Jenny , Mejía-Murillo Carmen , Flores-Reyes Gumercindo , Cruz-Cruz Oscar , Urcia-Quispe Manuel , Palomino-Márquez Manuel , Solar-Jara Miguel , Escobedo-Zarzosa Reyna
Published: December 2023

The impact of artificial intelligence in our society is important due to the innovation of processes through data science to know the academic and sociodemographic factors that contribute to late payments in university students, to identify them and make timely decisions for implementing prevention and correction programs, avoiding student dropout due to this economic problem, and ensuring success in their education in a meaningful and focused way. In this sense, the research aims to compare the performance metrics of classification models for late payments in students of a private university by using AutoML algorithms from various existing platforms and solutions such as AutoKeras, AutoGluon, HyperOPT, MLJar, and H2O in a data set consisting of 8,495 records and the application of data balancing techniques. From the implementation and execution of various algorithms, similar metrics have been obtained based on the parameters and optimization functions used automatically by each tool, providing better performance to the H2O platform through the Stacked Ensemble algorithm with metrics accuracy = 0.778. F1 = 0.870, recall = 0.904 and precision = 0.839. The research can be extended to other contexts or areas of knowledge due to the growing interest in automated machine learning, providing researchers with a valuable tool in data science without the need for deep knowledge.
Genomic Characteristics and Its Therapeutic Implications in Breast Cancer Patients with Detectable Molecular Residual Disease
Authors: Zhang Shu , Jiang Yan , Zhou Lu , Xu Jing , Zhang Gang , Shen Lu , Xu Yan
Published: December 2023

PurposeMolecular residual disease (MRD) is the main cause of postoperative recurrence of breast cancer. However, the baseline tumor genomic characteristics and therapeutic implications of breast cancer patients with detectable MRD after surgery are still unknown.Materials and MethodsIn this study, we enrolled 80 patients with breast cancer who underwent next-generation sequencing-based genetic testing of 1,021 cancer-related genes performed on baseline tumor and postoperative plasma, among which 18 patients had detectable MRD after surgery. ResultsBaseline clinical characteristics found that patients with higher clinical stages were more likely to have detectable MRD. Analysis of single nucleotide variations and small insertions/deletions in baseline tumors showed that somatic mutations in MAP3K1, ATM, FLT1, GNAS, POLD1, SPEN, and WWP2 were significantly enriched in patients with detectable MRD. Oncogenic signaling pathway analysis revealed that alteration of the Cell cycle pathway was more likely to occur in patients with detectable MRD (p=0.012). Mutational signature analysis showed that defective DNA mismatch repair and activation-induced cytidine deaminase (AID) mediated somatic hypermutation (SHM) were associated with detectable MRD. According to the OncoKB database, 77.8% (14/18) of patients with detectable MRD had U.S. Food and Drug Administration–approved mutational biomarkers and targeted therapy.ConclusionOur study reports genomic characteristics of breast cancer patients with detectable MRD. The cell cycle pathway, defective DNA mismatch repair, and AID-mediated SHM were found to be the possible causes of detectable MRD. We also found the vast majority of patients with detectable MRD have the opportunity to access targeted therapy.
Poster (Technology Innovation) ID 1970531
Authors: Barua Ujjoyinee , Holmes Jeffery , Loh Eldon , Teasell Robert , Sequeira Keith , Wolfe Dalton , Mehta Swati
Published: December 2023

Background/Objective

Spinal cord injuries (SCI) have a devastating effect on individuals incurring this life-changing event; however, it can also affect those integrally involved in their care. Family caregivers often experience negative outcomes, including high levels of burden, leading to decreased psychological well-being. Cognitive behavioural therapy is the most evidence-based treatment to help people identify and modify thoughts and behaviours contributing to their mental health concerns. However, several resource limitations exist. Guided internet-delivered cognitive behaviour therapy (ICBT) offers an evidence-based and accessible approach to psychosocial service delivery. ICBT improved psychosocial outcomes, including depression among persons with chronic health conditions. However, the efficacy of ICBT has yet to be evaluated among these caregivers.

Methods/Design

We present the protocol of the Well-being Care Partners Program, a 10-week clinician-guided ICBT program tailored for SCI caregivers to improve their well-being. The program was developed through participatory action research involving seven expert members (i.e., clinicians, people with lived experiences). We aim to recruit 30 participants to pilot this program. Participants will complete measures at baseline, post-intervention, and three months post-intervention. The primary outcome will be feasibility assessed through acceptability and limited efficacy (i.e., depression, anxiety, caregiver burden) as suggested by Bowen’s feasibility framework.

Discussion

This is one of the first pilot trials to test the feasibility, acceptability, and efficacy of a guided ICBT program for SCI caregivers. ICBT is designed to deliver an evidence-based intervention to overcome face-to-face therapy barriers and reach a wider group of patients, including those who might experience difficulties accessing health care.
Student Competition (Knowledge Generation) ID 1973368
Authors: Pei William , Fok Kai Lon , Tajali Shirin , Lee Jae Woung , Atputharaj Sharmini , Musselman Kristin , Masani Kei
Published: December 2023

Background

Individuals with an incomplete spinal cord injury (iSCI) have increased risk of falls during walking and standing. Our previous longitudinal pilot study demonstrated that a therapeutic system (FES+VFT system) using functional electrical stimulation (FES) and visual feedback training (VFT) improved the standing balance of individuals with iSCI.

Purpose

This study investigated the orthotic and acute therapeutic effects of FES in the FES+VFT system.

Participants

Fifteen individuals with iSCI will be recruited for this study. To date, four participants have completed the study.

Methods

The four participants completed three different sessions. In the first session, participants were evaluated for their balance, postural control and familiarized with the FES+VFT system. In the second and third sessions, the participant completed training sessions with the FES+VFT system with or without FES. Centre of pressure (COP) data were collected via force platforms. Before and after the training, the motor evoked potentials (MEP) of the soleus and tibialis anterior muscles were recorded.

Results

There was a greater increase in the total dynamic range of the COP with FES+VFT than VFT (Anterior posterior: increase of 17.5 ± 14.27mm, medial lateral: increase of 17.9 ± 19.45mm). Both the soleus and tibialis anterior muscles showed greater increases in MEP after FES+VFT than VFT (Soleus: 70.4 ± 31.1% vs 5.45 ± 29.1%; Tibialis Anterior: 115.3 ± 234.8% vs 11.0 ± 42.9%).

Conclusions

These findings suggest that FES improves the performance of VFT (positive orthotic effect) and increases the corticospinal connection (positive acute therapeutic effect) in individuals with iSCI.
Student Competition (Knowledge Generation) ID 1984525
Authors: Sequeira Nicholas , Craven Beverley C.
Published: December 2023

Background

Drug-induced myelopathy has been reported widely for heroin use, but less frequently for amphetamines or fentanyl. Hyperglycemia-induced acute myelopathy has not previously been described.

Methods

We present a case of toxic/metabolic myelopathy secondary to the aforementioned results in a patient presenting for tertiary inpatient rehabilitation.

Results

A 28-year-old man with Type 1 Diabetes without complications and polysubstance use (fentanyl and crystal methamphetamine) presented to hospital with quadriparesis and anesthesia. Patient reported he fell down a flight of stairs while using substances and remained on the ground for hours-days as he was acutely paralyzed when he awoke. Initial examination demonstrated a C5 motor level. Pan-CT demonstrated no intracranial or spinous abnormalities. MRI with gadolinium showed cord edema from C1-T4 and patchy enhancement from C4-C7 without cord compression. Diffusion restriction and hemorrhagic transformation were later seen in C4-C7. Initial blood glucose was 66 with no serum ketones. Serum toxicology was negative and urine toxicology was positive for amphetamines and fentanyl. Autoimmune and infectious workups were negative. He received 5 days of pulse steroids and 7 sessions of plasmapheresis with minimal functional or neurological improvement. He was admitted to rehabilitation as a C5 AIS-B and did not exhibit further improvement in motor or sensory function over 3 months of active inpatient rehab.

Conclusions

Given the pattern of cord enhancement with hemorrhagic transformation, this injury most likely represents acute myelitis induced by hyperglycemia and amphetamines/fentanyl. To our knowledge, this is the first case report where hyperglycemia may have contributed to acute myelopathy.
Poster (Technology Innovation) ID 1984794
Authors: Li Guijin , Balbinot Gustavo , Furlan Julio C. , Kalsi-Ryan Sukhvinder , Zariffa José
Published: December 2023

Background

Cervical spinal cord injury (SCI) can cause significant impairment and disability with an impact on individuals’ quality of life and independence. Surface electromyography (SEMG) is a sensitive and non-invasive technique to measure muscle activity and has demonstrated great potential in capturing the impact from SCI. The mechanisms of SCI damage on SEMG signal characteristics are multi-faceted and difficult to study in vivo.

Objective

Use validated computational models to characterize changes in SEMG signal after SCI and identify SEMG features that are sensitive and specific to the impact from different aspects of SCI.

Method

Starting from existing computational models for motor neuron pool organization and for motor unit action potential generation for healthy neuromuscular systems, we set up scenarios to model alterations in upper motor neurons, lower motor neurons, and the number of muscle fibers within each motor unit after SCI. After simulating SEMG signals from each scenario, we extracted time and frequency domain features and investigated the impact of SCI disruptions on SEMG features using the Pearson correlation between a feature and the extent of a given disruption.

Findings

Commonly used amplitude-based SEMG features cannot differentiate between injury scenarios. A broader set of features provides greater specificity to the type of damage present.

Conclusion

We demonstrated a novel approach to mechanistically relate SEMG features to different types of neuromuscular alterations after SCI. This work contributes to a deeper understanding and exploitation of SEMG in clinical applications, which will ultimately improve patient outcomes after SCI.
Student Competition (Knowledge Generation) ID 1985159
Authors: Okusanya Deborah O. , Porter Jane A. , Mann Darren J. , Karamzadeh Zahra , Hemakumara Sisuri G. , Barss Trevor S. , Mushahwar Vivian K.
Published: December 2023

Background

When we walk, we swing our arms in rhythm with our legs due to neural connections in the spinal cord. Currently, rehabilitation protocols primarily focus on leg training to improve walking function. However, past research has highlighted the importance of engaging the arms in rehabilitative interventions through arm and leg cycling following an incomplete spinal cord injury (iSCI).

Objectives

The objective of this study is to determine if the application of non-invasive transcutaneous spinal cord stimulation (tSCS) paired with arm and leg cycling can improve walking for individuals with an iSCI. It is hypothesized that the addition of tSCS will activate previously inaccessible neural circuits within the spinal cord to produce significant improvements in walking capacity.

Methods

Individuals with an iSCI underwent arm and leg cycling training that was assisted by functional electrical stimulation applied to the main extensor muscles of the leg. tSCS was applied over the cervical and lumbar regions of the spinal cord. Training consisted of 1 hour of cycling, 5 days/week for 12 weeks. A series of clinical and biomechanical assessments were performed to assess changes in functional mobility.

Results

Preliminary results in three participants showed increases in maximal walking speed on the 10-metre walk test, increases in walking endurance on the 6-minute walk test, and improved balance on the Berg Balance Scale. Preliminary biomechanical results suggested that the addition of tSCS may reduce left-right asymmetry.

Conclusions

Arm and leg cycling paired with tSCS offers tremendous potential for improvements in walking function following an iSCI.
Workshop (Knowledge Generation) ID 1985178
Authors: Chernesky John
Published: December 2023

Background

As more research funding agencies require grant applications to include an array of stakeholder expertise, a clear and well-thought-out Engagement Plan is necessary to ensure grant reviewers understand how projects will engage relevant stakeholders.

Objectives

Provide a comprehensive framework for drafting Engagement Plans for grant applications that will strengthen research proposals, help to mitigate tokenism and lead to more meaningful engagement in SCI research.

Overview

This presentation will describe in detail the key components you should include in your grant Engagement Plan, including tools you can utilize to select ideal project partners, develop an activity timeline, choose appropriate engagement methodologies, and prepare an accurate budget. Drawing on established best-practices in meaningful engagement, this presentation will guide delegates through the various components funding agencies expect to see in a thorough Engagement Plan. A novel framework will be shared that addresses common shortcomings in Engagement Plans and provides clear guidance on the elements to include in your grant submissions.

Conclusions

A detailed Engagement Plan clarifies to grant reviewers the steps you intend to take to ensure meaningful engagement in your proposed work, and will help set your application apart in the highly competitive research funding market.
Poster (Clinical/Best Practice Implementation) ID 1985182
Authors: Chase Andrea D. , Cordner Sharol E. , Duley Jennifer M. , Doupe Marty , Giurleo Charlie , Hong Julianne W. Y. , Kras-Dupuis Anna , Ventre Anellina , Watson Julie , Wolfe Dalton L. , Xia Nancy
Published: December 2023

Background

Persons with spinal cord injury (SCI) are at increased risk of developing pressure injuries throughout their lifetime. This significant yet preventable secondary complication can have a negative impact on one’s health and well-being. A key aspect of prevention is performing regular daily skin checks; however, a gap in knowledge is apparent among clinicians and patients on how exactly to perform them.

Objective

To develop a universal and widely available skin check video resource that supports clinicians and patients.

Methods

Clinicians across the SCI-IEQCC Network from Parkwood Institute, Hamilton Regional Reha-bilitation Centre, Ottawa Hospital Rehabilitation Center, Lyndhurst, Providence Care, and in partnership with SCIO, Cortree and persons with lived experiences, all contributed in an iterative manner to the development of a skin check video resource. Feedback from all relevant stakeholders was gathered after each round of edits to ensure the content would meet the educational needs of persons with lived experience and rehabilitation staff.

Results

This collaboration allowed for the development of an open-source skin check video resource for both clinicians and persons with lived experience. This video is in process of being integrated within patient skin check education of the various rehabilitation sites across Ontario. The video identifies key factors to consider when completing skin checks and demonstrates the technique on how to complete skin checks independently and with assistance.

Conclusion

While a successful skin check video resource was created, next steps will look to its sustainable implementation and dissemination at a local and provincial level.
Poster (Clinical/Best Practice Implementation) ID 1985364
Authors: Khorasheh Triti , Langford Lucie , Croosfernando Mariza , Richards Dawn , Craven Beverley Catharine
Published: December 2023

Background/objectives

The engagement of people with lived experience (PLEX) of spinal cord injury/disease (SCI/D) in rehabilitation research can lead to relevant questions and improved data collection, interpretation, knowledge translation, and research impact. We describe the process to create a toolkit which elaborates the roles that PLEX can play in rehabilitation research to ensure engagement is authentic and effective.

Methods

Five separate working groups were convened to each focus on a specific role of PLEX: research team member, peer reviewer, knowledge translator, decision-maker, and fundraising ambassador. The roles of PLEX in research, relevant training tools, and indicators to measure engagement were explored through 17 virtual meetings with 45 scientists, research staff, learners, and PLEX. Menti-meter and Survey Monkey were used to select training tools via consensus. A summative meeting was held with all participants to achieve consensus regarding the role descriptions. Meeting transcripts and survey data informed iterations of the materials prior to achieving consensus.

Findings

The Toolkit contains five role descriptions for PLEX as well as example activities, training requirements for scientists and PLEX, and specific indicators for each role. The Toolkit includes several best practice considerations and three practical tools for researchers to plan engagement, facilitate compensation, and implement/evaluate engagement.

Conclusions

The Toolkit can be used by researchers and research organizations to develop, implement, and evaluate engagement plans with PLEX in SCI/D rehabilitation research. This Toolkit can be used to transform the SCI/D rehabilitation research and advocacy agenda, and contribute to more relevant research with a greater impact.
Student Competition (Knowledge Generation) ID 1987548
Authors: Brockie S. , Zhou C. , Movahed M. , Hong J. , Fehlings M.G.
Published: December 2023

Background

Degenerative cervical myelopathy (DCM) is the most common form of spinal impairment worldwide and is caused by a series of degenerative changes that compress the spinal cord. DCM can be treated with surgical decompression (DEC), but recovery is impaired by secondary injury, such that 44% of patients who undergo DEC never regain lost function, and 9% experience persistent decline. The fractalkine receptor, CX3CR1, is expressed by monocyte-derived macrophages and CNS-resident microglia, where it mediates communication with neurons expressing its ligand, CX3CL1, and maintains phagocytic, migration, and injury response functions.

Objective

The purpose of this study is to determine the role of fractalkine in degeneration and post-surgical injury. We hypothesize that CX3CR1 expression is elevated by DCM and DEC and that inhibiting it may attenuate inflammation and improve functional outcomes.

Methods

To determine this, I am using a mouse model of C5-6 myelopathy in Cx3cr1-knockout and wildtype mice to produce functional degeneration and neuropathic pain across a 12-week period.

Results

Immunostaining of spinal tissue from myelo-pathic wildtype mice indicates upregulation of CX3CR1 throughout DCM and confirms this expression to be mediated by resident microglia. Inhibiting fractalkine signalling attenuates neuropathic pain across DCM progression. Following DEC, these benefits are reversed, and knockouts experience more pain up to 5 weeks post-surgery, suggesting a critical role for CX3CR1 in mediating secondary injury.

Conclusions

My findings thus far indicate a significant role played by fractalkine signaling in DCM and DEC recovery and posit microglia as a target for therapeutic intervention.
Workshop (Clinical/Best Practice Implementation) ID 1998666
Authors: Rockall Shannon , Hektner James , Donia Scott , Chernesky John , Noonan Vanessa
Published: December 2023

Background

Persons with lived experience of SCI (PLEX) living in rural areas have difficulty accessing optimal care and are required to travel long distances to access specialized services. Clinicians not affiliated with specialized urban centres recognize that developing knowledge and skills specific to SCI will improve care outcomes. Praxis has conducted multiple workshops on SCI topics throughout the BC Interior Health Region to improve clinician knowledge about SCI. Topics include pressure injuries, autonomic dysreflexia, specialized equipment, bowel and bladder, etc. Utilizing evidence-based information and PLEX experiences, these workshops have increased clinician confidence when working with clients with SCI.

This interactive workshop explores the development and implementation of the sessions, from the perspectives of a clinician, a PLEX, and a knowledge exchange expert.

Objectives

The goals of this workshop are to:

Conclusion

This workshop demonstrates the benefit of SCI knowledge exchange for clinicians working in rural areas. Furthermore, it highlights key factors in developing these workshops, and provides an opportunity to connect with other rural SCI initiatives and networks aimed at enhancing the care and well-being of PLEX.
Workshop (Knowledge Generation) ID 2001810
Authors: Mehta S , Nugent M , Prasad K , Upper R , Loh E , Teasell R , Sequeira K , Wolfe D , Titov N , Dear B , Hadjistavropoulos H.D
Published: December 2023

Background

Guided internet-delivered CBT (ICBT) offers an alternative approach for mental health service delivery in the community for those with spinal cord injury (SCI). However, there is a lack of evidence to support its use through large, controlled trials.

Study Objectives

The primary aim of the current study is to explore the efficacy of ICBT in reducing symptoms of depression and anxiety among persons with SCI compared to an online SCI Rehabilitation Education program.

Learning Objectives

Upon completing this workshop, attendees will: 1) understand the state of mental health among those post SCI; 2) explain the evidence behind guided ICBT among those post SCI; 3) apply cognitive behaviour therapy skills.

Overview

The presenters of this workshop will engage in lecture to provide current state of evidence for ICBT among those post SCI, conduct small-group discussions to apply CBT skills and examine barriers and facilitators of implementing the program.

Methods

Participants (n=122) endorsing symptoms of depression and/or anxiety related to SCI were randomized to an 8-week transdiagnostic ICBT program for those with SCI or an online SCI Rehabilitation Education program. Participants completed measures on depression, anxiety, self-efficacy, quality of life, and pain at pre-, post-, 3-months, and 6-months post-intervention.

Results

Significantly greater improvements in depression, anxiety, self-efficacy, quality of life, and pain interference were seen in the ICBT group compared to the Education group at post treatment and follow-up. Completion rates (∼90%) and satisfaction (>90%) were high in both groups.

Conclusions

The findings provide evidence for the superiority of ICBT over education in improving well-being among those with SCI.
Poster (Clinical/Best Practice Implementation) ID 2004605
Authors: Milligan James , Lee Joseph , Harrison Allison , MacGregor Kathleen
Published: December 2023

Background/Objectives

The Centre for Family Medicine Mobility Clinic strives to provide high quality primary care to persons living with spinal cord injury or other health conditions that affect mobility. The Mobility Clinic Resource Abilities Council (MC RAC) was established to serve in an advisory capacity, making recommendations on matters that impact the experience of patients with physical disabilities and their support persons at the Mobility Clinic.

Objectives

MC RAC provides feedback on, and ideas for initiatives and programs that support and enhance the model of person-centred care. It also advances collaborative patient engagement and person-centred care principles and practices within primary care for persons with physical disabilities

Methods/Overview

Members include individuals with lived experience with physical disability, their support persons, and Mobility Clinic staff. The council was established August 2022 and meets virtually once per month for approximately 90 minutes.

Results

MC RAC has successfully met nine times and has provided feedback on the following topics: Breast & Cervical Cancer screening Initiative for People with Physical Disabilities, Mobility Clinic website development, building pathways for advocacy with the KW4 OHT, Circulus Network webinar topics, Mobility Clinic organization and clinical flow. Feedback to be implemented into Mobility Clinic activities.

Conclusions

Patient and support persons involvement in decision-making processes improve care experiences and contribute to better health outcomes for patients. We will continue to work and develop our patient advisory council to better support the Mobility Clinic’s patients and their support persons.
Yaşlı bireyler için giyilebilir teknolojilerinin kullanımı ve değerlendirilmesi
Authors: TURGUT Zeynep Nur , DANIŞAN Tuğba , GÜVEN Emel , EREN Tamer
Published: December 2023

Teknolojinin gelişmesiyle günlük hayatta birçok alanda kullanılmaya başlayan giyilebilir teknolojiler; verileri toplayan, kullanıcı hareketlerini izleyen ve kullanıcının istekleri doğrultusunda özelleştirilebilen cihazlardır. Giyilebilir teknolojiler sayesinde bireylerin günlük yaşamda yaptıkları aktiviteleri ve sağlık verileri analiz edilebilmektedir. Günümüzde COVID-19 pandemi süreciyle birlikte en çok, kronik hastalığı olan ve yaşlı olan bireyler etkilenmiştir. Pandemi süreci devam ederken yaşlı bireyler hastaneye, doktorlara ve sağlık personellerine ulaşmakta zorluk çekmektedirler. Giyilebilir teknoloji ürünleri sayesinde izolasyon sürecinde, yaşlı bireylerin takibi gerçek zamanlı olarak incelenebilmektedir. Aynı zamanda sağlık kontrollerinin yapılması, acil durumlarda sağlık personellerine haber verme gibi özellikler de bulunmaktadır. Bu doğrultuda, “yaşlı bireyler için en uygun giyilebilir teknoloji ürünü hangisidir?” sorusuyla en uygun ürün seçimi yapılmıştır. Yapılan bu çalışmada yaşlı bireylerin günlük takibini sağlayan giyilebilir teknoloji ürününün seçilmesi ve değerlendirilmesi problemi ele alınmıştır. Problemin çözümünde AHP, TOPSIS ve PROMETHEE yöntemleri kullanılmıştır. Problem kapsamında belirlenen kriterler ise SOS(Acil Durum) araması, kullanım kolaylığı, fiyat, pil ömrü ve sensör adet sayısıdır. MobileHelp, MePACS Solo, Freedom 2.0, Galaxy Watch ve Apple Watch alternatifleri oluşturmaktadır. Belirlenen kriter ve alternatifler doğrultusunda, yaşlı bireyler için en uygun giyilebilir teknoloji ürününün seçimi amaçlanmaktadır.
Media image of corruption in the private sector
Authors:   Teaching Associate, University of Belgrade, Faculty of Security Studies, Marković Jana
Published: December 2023

Corruption has long existed as a all-around social phenomenon characterized by complexity and action that takes place "far from the public eye". Various forms of corrupt activity, regardless of whether they are manifested in the public or private sector, threaten the values of every society. Although originally associated with the state and (its) officials with public powers, there is more and more talk about corporate corruption that manifests itself in the private sector or the area of overlap between the public and private spheres. The author's premise is that the media plays a crucial role in combating corruption through the media discourse that shapes public perception and reality of this issue. The objective is to outline the characteristics of the media portrayal of corruption. The discussion focuses on the media's contribution to fighting corruption and also addresses the obstacles that hinder media coverage, resulting in a distorted representation of corruption.
THE EFFECTS OF REIMPLEMENTING A BIOMETRIC ATTENDANCE MONITORING SYSTEM IN THE ELECTRONICS ENGINEERING DEPARTMENT AT DON HONORIO VENTURA STATE UNIVERSITY
Authors:   Faculty of General Engineering, Holy Angel University, Pampanga, Philippines, Frigillana Katherine G. , Jocson Joefil C. ,   Faculty, Graduate School, Nueva Ecija University of Science and Technology, Nueva Ecija, Philippines, Muldong Roviel Manfre C. ,   Revit Specialist Manager, Joii Workstream-Homecorp Construction, Pampanga, Philippines, Natividad Lester O. ,   Faculty of Electronics Engineering, Don Honorio Ventura State University, Pampanga, Philippines, Tiongson Hazel T. ,   Faculty of General Engineering, Holy Angel University, Pampanga, Philippines
Published: December 2023

Monitoring the attendance of staff and employees holds paramount importance in organizational settings. This can be accomplished either manually, using logbooks and daily time records, or automatically through advanced technologies such as radio frequency identification, biometrics, and bar code scanners. Biometrics attendance monitoring systems, in particular, offer a range of benefits, including heightened security, accuracy, convenience, scalability, time efficiency, compliance, and accountability. This research paper elucidates the advantages of the biometric system, examining its impact on the employees of the Electronics Engineering Department at Don Honorio Ventura State University during the 1st Semester of the Academic Year 2023-2024. The Biometrics Attendance System proves to be exceptionally effective and efficient, gaining a consensus of 92% among participants regarding its positive impacts. Ratings consistently hover at 4 or 5 for efficiency, underscoring the streamlined processes. Accessibility earns a positive average score of 80%, and privacy measures receive an equally commendable average score of 82%. While the system generally contributes positively to managing absenteeism, an outlier score of 1 from a participant prompts further investigation. In conclusion, the Biometrics Attendance System excels in effectiveness, efficiency, and user satisfaction, positioning itself as a secure, accurate, and convenient solution. This becomes especially relevant as the Electronics Engineering Department integrates the biometric system, reaping benefits in terms of security, accuracy, and time efficiency. However, it's noteworthy that the implementation of the biometrics attendance system correlates with an increase in faculty absenteeism. Addressing specific concerns identified in the Manual Attendance System could guide targeted improvements for a more comprehensive and satisfactory attendance monitoring system overall.
Implementation of Machinery Breakdown Insurance at PT Semen Indonesia
Authors:   Faculty of Law, Wijaya Kusuma Surabaya University, Subagiyo Dwi Tatak , Setiawan Ahmad ,   Student Magister of Law, Faculty of Law, Wijaya Kusuma Surabaya University, Herlina Indah ,   Student Magister of Law, Faculty of Law, Wijaya Kusuma Surabaya University
Published: December 2023

This research relating to insurance for operational machines at PT Semen Indonesia raises problems, namely: What is the object of implementing Machinery Breakdown Insurance in practice at PT. Semen Indonesia, and how to settle claims contained in insurance at PT. Indonesian Cement. The research results stated that, In this case the object insured by PT. Semen Indonesia to PT. Jasindo is all damage and/or that is sudden and unexpected and is not excluded in the policy or the machines insured. Compensation guarantee in Machinery Breakdown Insurance between PT. Semen Indonesia with PT. Jasindo if a loss occurs, what PT Jasindo will pay to PT Semen Indonesia is based on the damage.In the event of an insurance claim for machine damage, PT Semen Indonesia must immediately notify PT Jasindo about the loss/damage within 7 (seven) calendar days and must assist PT Jasindo in conducting a survey to calculate the compensation that will be given. PT Jasindo’s responsibility is to compensate for losses due to the asset’s condition becoming its original condition, without taking into account profit or loss. In this case, PT Jasindo is responsible within 3 x 24 hours and beyond that time PT Jasindo is no longer responsible. If there is a dispute regarding Machine Damage Insurance between PT Semen Indonesia and PT Jasindo in terms of claims, then PT Semen Indonesia and PT Jasindo agree to take legal action, namely through arbitration or through the local District Court.
The Synergy between Business Process and Big Data
Authors:   Compliance Manager, Pharmaceutical Product Development, Duggineni Sasidhar
Published: December 2023

The synergy of Big Data and cloud computing has ushered in a new era of data-driven innovation, transforming the way organizations store, process, and derive insights from vast and complex datasets. This comprehensive overview delves into the intersection of Big Data and cloud computing, exploring key technologies, scalability, elasticity, data warehousing, NoSQL databases, distributed data processing, and the benefits they offer. By harnessing the power of cloud-based resources, organizations can efficiently manage their data resources, optimize performance, control costs, and gain a competitive edge in the data-centric landscape.
AI-Powered Recruitment The Future of HR Digital Transformation
Authors:   HR Digital Transformation Architect, US Foods Inc. Rosemont, IL USA, Nyathani Ramesh
Published: December 2023

In an era marked by rapid technological advancements, Human Resources (HR) digital transformation has become a strategic imperative for organizations seeking to stay competitive in talent acquisition and management. This paper delves into the evolution of HR digital transformation, emphasizing the pivotal role played by Artificial Intelligence (AI)-powered recruitment solutions. This paper provides a context for understanding the significance of AI in redefining traditional recruitment practices and the multifaceted role of AI in recruitment, highlighting its benefits such as efficiency gains, improved candidate matching, and enhanced candidate experiences. At the same time, it addresses the challenges associated with AI adoption, including data privacy concerns, fairness and bias issues, and barriers to implementation. The paper then examines various AI technologies deployed in recruitment, including chatbots, natural language processing (NLP), machine learning algorithms, predictive analytics, and video interviews. Furthermore, it presents best practices for organizations looking to implement AI in recruitment successfully, covering aspects like strategy development, data management, fairness considerations, and user adoption. The paper explores the future of AI-powered recruitment, highlighting emerging trends, potential integrations with other HR functions, and the evolving role of HR professionals in the AI era. Ethical considerations, including addressing bias and ensuring transparency, are also thoroughly examined to ensure responsible AI adoption. Through a comprehensive review of the current landscape and ethical considerations, this paper equips HR practitioners, organizational leaders, and researchers with valuable insights into the transformative potential of AI-powered recruitment. It underscores the importance of strategic AI adoption in HR digital transformation, offering a roadmap for organizations seeking to harness AI's capabilities for the future of talent acquisition and management
Journal of Engineering and Applied Sciences Technology
Authors:   Amazon.com, LLC, Amazon Music, City Seattle, State WA, USA, Vishnu Kadam Ashlesha
Published: December 2023

Voice assistants are finding adoption because of their ease and intuitiveness of use. While voice has been the dominant mode of interaction of humans with voice assistants, some embodiments of voice assistants also provide alternative modalities for interaction, popularly, via visual or touch interface. In this paper, the end-to-end working of a multi-modal voice assistant is provided, followed by a deep dive into the challenges associated specifically with multimodal voice assistants. This is followed by mitigation strategies for the challenges arising out of multimodal interaction scenarios. Next, architectural and design guidelines are provided that can provide a seamless user experience. Finally, future research areas have been identified