bluuebunny/crossref_metadata_2025 huggingface dataset:
A bibliometric analysis: Current status and frontier trends of Schwann cells in neurosciences
Authors: Wang Yan , Zhang Shiwen , Zhi Jincao , Huang Meiling , Pei Fei
Published: January 2023

Background

This review aims to present a comprehensive bibliometric analysis related to Schwann cells (SCs) in neurosciences from 2012 to 2021.

Methods

We used the Web of Science core collection database to obtain publications on SCs in the field of neurosciences from 2012 to 2021. The obtained data were further visually analyzed by using CiteSpace, VOSviewer, and an online bibliometric platform.

Results

We retrieved a total of 1,923 publications related to SCs in neurosciences. The number of publications in this field fluctuates steadily each year, and the number of citations is increasing year by year. The United States is leading the field, with LERU and the University OF London as influential institutions, Jessen KR and Feltri ML as the most representative authors, and GLIA and JOURNAL OF NEUROSCIENCE as authoritative journals in the field. Meanwhile, we predict that a more in-depth study of autophagy and phagocytosis functions of SCs and the key regulator c-Jun will probably be a hot spot for future research.

Conclusion

This study summarizes the current research results and predicts research trends for further research, which will facilitate researchers in quickly understanding the current state of research in the field while referring to new research directions.
Real time monitoring and evaluation of the inhibition effect of fucoxanthin against α-amylase activity by using QCM-A
Authors: Yin Shipeng , Siahaan Evi Amelia , Niu Liqiong , Shibata Mario , Liu Yuanfa , Hagiwara Tomoaki
Published: January 2023

The main symptoms of diabetes are hyperglycemia and insulin resistance. The inhibition of the starch digestion enzymes could effectively regulate starch digestion and glucose absorption, thereby slowing or treating the symptoms of postprandial hyperglycemia. Herein, we used fucoxanthin isolated from Undaria pinnatifida stems, as α-amylase inhibitor, and monitored the interactions of both biomolecules by using quartz crystal microbalance-admittance (QCM-A) instrument. All the processes of α-amylase hydrolysis of starch were also dynamically tracked by using amylose-immobilized QCM technology. In our work, we found that the kinetic parameter (koff, kon, and kcat) values obtained by the QCM-A analysis were relatively consistent compared to the kinetic parameter values obtained by the conventional Michaelis–Menten analysis. For the inhibitory reactions, the results showed that fucoxanthin significantly reduced the activity of α-amylase in a dose-dependent manner. The QCM-A technology shown to be an excellent approach in obtaining comprehensive and accurate kinetic parameters, thereby providing real and accurate data for kinetic studies. It is helpful to clarify the mechanism of action of fucoxanthin on α-amylase, which further proved the potential of fucoxanthin to improve and treat postprandial hyperglycemia.
Case report: Severe hepatic fibrosis induced by chronic cholestasis of congenital biliary dilation treated by laparoscopic surgery after immunonutrition support– An infantile case
Authors: Sugita Koshiro , Onishi Shun , Muto Mitsuru , Nishida Nanako , Nagano Ayaka , Murakami Masakazu , Harumatsu Toshio , Yamada Koji , Yamada Waka , Kawano Takafumi , Ieiri Satoshi
Published: January 2023

Introduction

In some patients with congenital biliary dilation (CBD), biliary cirrhosis has been reported to rapidly progress from the neonatal period to the infantile period. We herein report an infantile case of CBD that showed severe biliary cirrhosis at the diagnosis, which was treated by laparoscopic surgery.

Case presentation

A 16-month-old girl underwent conservative therapy for liver dysfunction and cholangitis on a remote island of our prefecture. She was transferred to our hospital after the detection of a huge dilated common bile duct on imaging at the previous hospital. Contrast-enhanced computed tomography showed a dilated common bile duct (maximum diameter: 5 cm), thus suggesting CBD. However, her laboratory data on admission showed a poor nutritional status and severe liver dysfunction (Alb, 2.5 mg/dl; AST, 79 IU/L; ALT, 43 IU/L; γ-GTP, 491 mg/dl; D-bil, 0.3 mg/dl; CHE, 90 IU/L; NH3, 123 μg/dl). We initially performed laparoscopic exploration and bile drainage via the gallbladder, noting severe hepatic fibrosis resembling end-stage liver cirrhosis. After placing a drainage tube in the gallbladder, cholangiography was performed. Cholangiography showed Todani type IVa CBD with pancreaticobiliary maljunction. Contrast agent flowing into the duodenum could not be confirmed. The patient received liver-supporting therapy and nutritional support for 7 weeks before definitive surgery. Following the improvement of the hepatic synthetic capacity (Alb, 4.0 mg/dl; AST, 82 IU/L; ALT, 78 IU/L; γ-GTP, 157 mg/dl; D-bil, 0.2 mg/dl; CHE, 232 IU/L; NH3, 75 μg/dl), we performed extrahepatic bile duct excision and hepaticojejunostomy laparoscopically. Laparoscopic surgery was successfully performed along with liver biopsy. Histopathologically, the liver specimen showed chronic hepatitis and fibrosis (F3A2). Biliary scintigraphy showed good bile excretion at postoperative day 15. The postoperative course uneventful, and the patient was discharged on the 23rd day after surgery. A needle liver biopsy six months later showed mild improvement of chronic hepatitis and fibrosis (F2-3A1). The patient was regularly followed at the outpatient clinic.

Conclusions

Severe liver fibrosis was suspected to be continuous cholestasis of CBD after birth. CBD with severe liver fibrosis may avoid liver transplantation by two-stage surgery with hepatoprotection therapy and immunonutritional support.
Panax ginseng C.A. meyer alleviates benign prostatic hyperplasia while preventing finasteride-induced side effects
Authors: Park Ja Yeon , Park Woo Yong , Song Gahee , Jung Se Jin , Kim Beomsu , Choi Minji , Kim Sang Hee , Park Jinbong , Kwak Hyun Jeong , Ahn Kwang Seok , Lee Jun Hee , Um Jae-Young
Published: January 2023

Panax ginseng C.A. Meyer, a widely used traditional medicine in East Asia, shows many beneficial effects on immune function, male erectile dysfunction, cancer, excessive oxidants, and aging issues. However, its effect on benign prostatic hyperplasia (BPH) and its potential in the treatment of side effects related to finasteride (Fi), an FDA-approved drug for BPH, are less known. This study aimed to verify the therapeutic effects of a water extract of P. ginseng (PGWE) on BPH in testosterone propionate (TP)-induced BPH rats and TP-treated RWPE-1 human epithelial cells, and the inhibitory potential on the Fi-induced side effects is also explored. In the TP-induced BPH rat model, PGWE alleviated the pathological markers of BPH such as weight and epithelial thickness of the prostate, and the serum level of dihydrotestosterone. PGWE downregulated androgen-related BPH factors such as 5α-reductase 2 and androgen receptor. PGWE also showed prostatic cell apoptosis accompanied by increased expression of Bax and decreased expression of Bcl-xL and cleaved-caspase 3, respectively, in addition to increasing mitochondrial dynamics in both in vivo and in vitro BPH models. Notably, reduced sperm count, one of the serious side effects of Fi, in the epididymis of BPH rats was recovered with PGWE treatment, suggesting less toxicity to sperm development by PGWE. PGWE also protected against Fi-induced sperm loss when PGWE was administered in combination with Fi without compromising the therapeutic effects of Fi on BPH. Based on these findings, we propose that PGWE could be an alternative therapeutic agent for BPH.
Locally resonant metasurface for low-frequency transmissive underwater acoustic waves
Authors: Chen Zhong , Guan Shenghong , Xie Qiang , Li Zheng , Gao Zhongmei , Negahban Mehrdad
Published: January 2023

Introduction: Acoustic metasurfaces for underwater wave manipulation have great potential use, but the strong solid-fluid interaction caused by impedance closeness between the structure and water brings design difficulty, especially in the low-frequency range.

Methods: Here a locally resonant metasurface for transmissive underwater acoustic waves is proposed using finite element method for which each metasurface unit consists of one channel and three subunits. Each subunit has one plate and two rubber spacers to form a resonator. By changing the height ratio of the plate over the subunit, arbitrary phase shifts within the full 2π coverage can be obtained at will with transmission ratio always higher than 60%.

Results: Three applications, including asymmetric transmission, self-bending, and source illusion, are chosen to validate the design methodology.

Discussion: Compared with previous transmissive type underwater metasurface, this design has the advantage of low frequency and simple fabrication. This work provides a novel paradigm of modulating waves for ocean exploration, underwater communication, and submarine stealth and antidetection.
Effects of prolonged local vibration superimposed to muscle contraction on motoneuronal and cortical excitability
Authors: Pfenninger Clara , Grosboillot Nathan , Digonet Guillaume , Lapole Thomas
Published: January 2023

Introduction: Acute effects of prolonged local vibration (LV) at the central nervous system level have been well investigated demonstrating an altered motoneuronal excitability with a concomitant increase in cortical excitability. While applying LV during isometric voluntary contraction is thought to optimize the effects of LV, this has never been addressed considering the acute changes in central nervous system excitability.

Materials and Methods: In the present study, nineteen healthy participants were engaged in four randomized sessions. LV was applied for 30 min to the relaxed flexor carpi radialis muscle (VIBRELAXED) or during wrist flexions (i.e. intermittent contractions at 10% of the maximal voluntary contraction: 15 s ON and 15 s OFF; VIBCONTRACT). A control condition and a condition where participants only performed repeated low-contractions at 10% maximal force (CONTRACT) were also performed. For each condition, motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation and cervicomedullary evoked potentials (CMEPs) elicited by corticospinal tract electrical stimulation were measured before (PRE) and immediately after prolonged LV (POST) to investigate motoneuronal and corticospinal excitability, respectively. We further calculated the MEP/CMEP ratio as a proxy of cortical excitability.

Results: No changes were observed in the control nor CONTRACT condition. At POST, CMEP decreased similarly in VIBRELAXED (−32% ± 42%, p < .001) and VIBCONTRACT (−41% ± 32%, p < .001). MEP/CMEP increased by 110% ± 140% (p = .01) for VIBRELAXED and by 120% ± 208% (p = .02) for VIBCONTRACT without differences between those conditions.

Discussion: Our results suggest that LV to the flexor carpi radialis muscle, either relaxed or contracted, acutely decreases motoneuronal excitability and induces some priming of cortical excitability.
Association between intimate partner psychological violence and psychological distress among nurses: The role of personality traits and social support
Authors: Huang Wentao , Zhang Fan , Sun Xibin , Yu Qing , Huang Jingxin , Su Yunhui , Lan Yutao
Published: January 2023

Aim

This study proposes investigating the risk and protective factors of intimate partner (IP) psychological violence and psychological distress to better promote psychological wellbeing for nurses and health outcomes for patients.

Design

A cross-sectional study.

Method

This cross-sectional study was carried out chiefly in Guangdong, Hunan, and Shaanxi provinces, in the east, central, and west of the Chinese economic areas, respectively. It was conducted in October 2021 using convenience sampling. A total of 843 nurses were eligible for the final analysis. Single-factor linear regression models were used to identify potential factors associated with IP psychological violence and psychological distress. In addition, the structural equation model was used to explore the role of personality traits and social support in the association between IP psychological violence and psychological distress.

Results

The predictors for the score of IP psychological violence among nurses were participants' married status, contact frequency with a partner, perceived past-year psychological and physical violence experience, the alcohol consumption of partners, and personality traits and social support of partners. Moreover, the alcohol consumption of participants, the past-year experience of IP psychological violence, the score of psychological violence, personality traits, social support, and the personality traits of partners were associated factors affecting the psychological distress of nurses. In the structural model, the personality trait of partners had a direct pathway to psychological violence and social support. The results demonstrated that psychological violence significantly increased psychological distress.

Conclusion

Personality traits and social support are essential factors influencing the relationship between IP psychological violence and psychological distress.

Impact

The findings of this study emphasize the possibility and importance of identification and intervention for reducing IP psychological violence based on personality traits and social support.
School counselors’ perceptions of virtual counseling in Lebanon: A qualitative study
Authors: Jaber Fatima , Al-Hroub Anies
Published: January 2023

Virtual counseling has become an increased necessity as a result of the current pandemic as well as the need for methods that comply with the continuous changes and advancements. Studies conducted have shown that the perceptions of counselors of the benefits and barriers reflect whether or not the counseling service will be successful. This study is a descriptive research design following a qualitative approach. The study aimed to explore (a) the school counselor’s perceptions of the benefits and barriers they encounter when using virtual counseling, (b) the perceived differences between conducting virtual counseling and in-person counseling, and (c) whether participation in virtual counseling differs as a result of students’ characteristics in the perception of school counselors. Five private schools in the Beirut region were contacted as they were known to have virtual counseling programs. Both the schools and counselors were purposively chosen. Seven in-depth semi-structured interviews and one focus group discussion (FGD) were carried out with the study participants. Interpretational analysis was carried out to assess and analyze the obtained data. The results showed that through these experiences, counselors were able to develop new methods with regard to technology and other practices to limit the effects of obstacles faced. Counselors’ communication tools were also fine-tuned since they had to rely on unorthodox methods to understand students and deal with them better. Results showed that the benefits also have to do with time and method flexibility, the main barriers were issues of privacy, change in workplace dynamics, and lack of usage of tools. The findings were discussed in relation to four main themes: (a) service delivery adaptation, (b) working with technology, (c) counselor’s practices in delivering virtual counseling, and (d) preparation and training for virtual counseling. Being that it is qualitative research, the interpretational analysis was carried out to assess the obtained data. The results showed that the main benefits have to do with time and method flexibility, and the main barriers were issues of privacy and change in workplace dynamics. The results showed that the new changes and the counselor’s experience, along with the personal attributes of counselors and students, all influenced the efficiency of the counseling sessions.
What is the burden of tinnitus?
Authors: Pryce Helen , Dauman Nicolas , Burns-O’Connell Georgina
Published: January 2023

Introduction

Tinnitus is a complex experience that often occurs alongside other health conditions, including hearing loss. In the UK, as in other western countries, patterns of health are changing with a rise in multi-morbidity and complexity of health conditions. As we age, we can expect to live with multiple health conditions. Burden of illness has long been recognised. Less well recognised is the burden that accumulates from the treatment of health conditions.

Methods

This qualitative thematic analysis of patient accounts described the cumulative burdens of tinnitus, both the experience of hearing the tinnitus and from the treatments undertaken. Between 2017-8 we conducted interviews with 38 participants who were help-seekers in a range of contrasting UK clinical services (Physician led, Audiology led and Hearing Therapy led). We examined these interview data using reflexive thematic analysis methods to identify and explore the cumulative burdens for those who live with and seek help for their tinnitus. Specifically, we used six phased approach to determine and group themes.

Results

The themes provide a coherent description of the nature of the burden that people with tinnitus experience.

Discussion

In tinnitus, as with most chronic health conditions, the largest treatment workload is devolved to the patient. Patients are required to implement treatments, learn about tinnitus and find new ways of coping. Yet this work happens invisibly, without recognition from clinicians who measure outcomes but not the efforts made to achieve outcomes. Patient-centred care depends upon the recognition of the cumulative burdens that patients experience.
Barriers and facilitators to the implementation of workplace health promotion programs: Employers' perceptions
Authors: Campmans Jennifer M. D. , Smit Denise J. M. , van Oostrom Sandra H. , Engels Josephine A. , Proper Karin I.
Published: January 2023

Background

Workplace health promotion programs (WHPPs) can benefit the lifestyle and health of employees. However, not all WHPPs have been successful in their implementation, and thus their effectiveness. This study aimed to identify the barriers and facilitators to implementing an integrated WHPP, which targets multiple lifestyle factors at different levels (individual and organizational), from an employer's perspective.

Methods

Data were collected by two online focus groups among 18 representatives of eight different organizations. Data from the focus group discussions were transcribed verbatim and analyzed using thematic analysis. Data were coded both inductively and deductively, using the Consolidated Framework for Implementation Research (CFIR) consisting of the following five domains: (1) intervention characteristics, (2) outer setting, (3) inner setting, (4) characteristics of individuals, and (5) process. Ratings were performed to indicate the positive or negative influence and strength of a construct regarding the implementation of WHPPs.

Results

Barriers and facilitators in all domains of the CFIR were found. Regarding characteristics of the WHPP, complexity and costs hindered implementation, while high adaptability facilitated it. An organization that met the needs of employees (the outer setting) facilitated implementation. Available resources, access to knowledge, leadership involvement, and continuity of communication were facilitators within the inner setting. Barriers were different approaches to implementation within one organization and the perceived interference with employees' lives. For the implementation process, the involvement of key stakeholders, including employees, was identified as an important facilitator.

Conclusion

Various barriers and facilitators in different domains play a role in the implementation of integrated WHPPs, according to employers. Strategies that tackle the identified barriers and incorporate the facilitators will likely contribute to the successful implementation of integrated WHPPs.
Evaluating the impact of community health worker certification in Massachusetts: Design, methods, and anticipated results of the Massachusetts community health worker workforce survey
Authors: Nielsen Victoria M. , Ursprung W. W. Sanouri , Song Glory , Hirsch Gail , Mason Theresa , Santarelli Claire , Guimaraes Erica , Marshall Erica , Allen Caitlin G. , Lei Pei-Pei , Brown Diane , Behl-Chadha Bittie
Published: January 2023

Background

Professional certification of community health workers (CHWs) is a debated topic. Although intended to promote CHWs, certification may have unintended impacts given the grassroots nature of the workforce. As such, both intended effects and unintended adverse effects should be carefully evaluated. However, there is a lack of published literature describing such effective evaluations with a robust methodology. In this methods paper, we describe a key component of evaluating CHW certification in Massachusetts-the Massachusetts CHW Workforce Survey.

Methods

Design of the surveys was informed by a program theory framework that delineated both positive and negative potential impacts of Massachusetts CHW certification on CHWs and CHW employers. Using this framework, we developed measures of interest and preliminary CHW and CHW employer surveys. To validate and refine the surveys, we conducted cognitive interviews with CHWs and CHW employers. We then finalized survey tools with input from state and national stakeholders, CHWs, and CHW employers. Our sample consisted of three frames based on where CHWs are most likely to be employed in Massachusetts: acute care hospitals, community-based organizations, and ambulatory care health centers, primarily community health centers and federally qualified health centers. We then undertook extensive outreach efforts to determine whether each organization employed CHWs and to obtain CHW and CHW employer contact information. Our statistical analysis of the data utilized inverse probability score weighting accounting for organizational, site, and individual response.

Anticipated results

Wave one of the survey was administered in 2016 prior to launch of Massachusetts CHW certification and wave two in 2021. We report descriptive statistics of the three sample frames and response rates of each survey for each wave. Further, we describe select anticipated results related to certification, including outcomes of the program theory framework.

Conclusions

The Massachusetts CHW Workforce Survey is the culmination of 5 years of effort to evaluate the impact of CHW certification in Massachusetts. Our comprehensive description of our methodology addresses an important gap in CHW research literature. The rigorous design, administration, and analysis of our surveys ensure our findings are robust, valid, and replicable, which can be leveraged by others evaluating the CHW workforce.
eSexualHealth: Preferences to use technology to promote sexual health among men who have sex with men and trans and gender diverse people
Authors: Abraham Esha , Chow Eric P. F. , Fairley Christopher K. , Lee David , Kong Fabian Y. S. , Mao Limin , Goller Jane L. , Medland Nicholas , Bavinton Benjamin R. , Sudarto Budiadi , Joksic Stefan , Wong Jessica , Phillips Tiffany R. , Ong Jason J.
Published: January 2023

Objectives

Gay, bisexual and other men who have sex with men (GBMSM) and trans and gender diverse (TGD) people are disproportionately affected by poorer sexual health outcomes compared to heterosexual populations. We aimed to explore the preferences of GBMSM and TGD for using eHealth for sexual health (eSexualHealth).

Methods

We distributed an anonymous online survey from April to August 2021among the lesbian, gay, bisexual, transgender, intersex, queer and other people of diverse sexuality or gender (LGBTIQA+) community in Australia. The survey collected data on sociodemographic characteristics and sexual behaviors, their preferences for app/website functions and preferred HIV and sexually transmitted infection (STI) testing reminders. We used descriptive statistics to summarize the characteristics of the study population. Free-text responses were thematically analyzed.

Results

Of 466 participants included, most identified as cisgender males (92.7%). The median age was 48 [interquartile range (IQR): 37–56]. For accessing sexual health-related information, 160 (34.6%) would use either a website or an app, 165 (32.7%) would prefer a website, 119 (25.8%) would prefer an app, and 33 (7.1%) would not use either platform. There was no significant difference between GBMSM and TGD people. Participants were most interested in information about STI clinics, HIV/STI hotspots, and sexual health education. Participants stressed the need for privacy and anonymity when using eHealth. Regarding reminders to test for HIV/STIs, receiving regular SMS was most popular (112/293, 38.2%), followed by regular emails (55/293 18.8%) and a reminder function on their phone (48/293, 16.4%).

Conclusion

Our study suggests a promising future for eHealth among GBMSM and TGD people. Sexual health is still a stigmatized area, and eHealth may circumvent barriers this population faces.
Heavy metals and trace elements contamination risks in peri-urban agricultural soils in Nairobi city catchment, Kenya
Authors: Ahogle Arcadius Martinien Agassin , Letema Sammy , Schaab Gertrud , Ngure Veronica , Mwesigye Abraham R. , Korir Nicholas K.
Published: January 2023

Introduction

With urbanization and industrialization in the developing world, urban and peri-urban agriculture is increasingly contributing to urban food systems, employment, and income generation opportunities. However, urbanization and industrialization may release harmful pollutants, including heavy metals and trace elements into agricultural soils, posing ecological, environmental and public health concerns. This paper assessed the potential risks of soil contamination with heavy metals and trace elements in peri-urban farmlands in Nairobi city catchment in Kenya.

Methods

A total of 60 soil samples were collected from ten vegetable farming zones (S1-S10) and processed following standard protocols. The concentrations of As, Cd, Co, Cr, Cu, Fe, Hg, Mn, Ni, Pb, V and Zn were analyzed in the samples using inductively coupled plasma-mass spectrometry (ICP-MS).

Results and discussion

Results revealed that the soil samples have elevated concentrations of As, Cd, Co, Cr, Cu, Fe, Hg, Mn, Ni, Pb, V and Zn, with some elements including As (1.7%), Cd (13.3%), Mn (80%), Pb (1.7%) and Zn (11.7%) exceeding the permissible thresholds for agricultural soils. The spatial distribution of the elements exhibited three similar distribution patterns with slight variations between the hotspot sites of the different elements: (i) Co and Mn, (ii) Cu and Cr and (iii) As, Cd, Fe, Hg, Pb and Zn, while Ni and V exhibited singular spatial distributions compared to other elements. Elements such as As, Cd, Co, Fe, Hg, Mn, Pb and Zn appeared to be of anthropogenic enrichment, while Cr, Cu, Ni and V appeared to originate mainly from lithogenic and natural sources. The elements As, Cd, Hg and Pb exhibited high ecological risks, with Cd contributing about 46-66% of the overall ecological risk. The sampling sites S1, S5, S7, S9 and S10 depicted the highest ecological risks of 145, 103, 146, 121 and 146, respectively. The findings call for proper zoning of suitable agricultural areas and sound waste management protocols in urban and peri-urban landscapes. Further, remediation of contaminated soils and farmers’ sensitization are recommended for ecological and public health risk alleviation.
Industrial symbiosis and agri-food system: Themes, links, and relationships
Authors: Hamam Manal , Spina Daniela , Raimondo Maria , Di Vita Giuseppe , Zanchini Raffaele , Chinnici Gaetano , Tóth József , D'Amico Mario
Published: January 2023

Industrial symbiosis is an eco-innovative system concept that is based on a circular economy and industrial ecology ideas. This process comprises the movement of materials, energy, and skills across enterprises located within eco-industrial parks, and strives to provide economic, environmental, and social competitive advantages for all the involved parties. Considering that the agri-food system creates a vast quantity of by-products along the supply chain, it is a sector that has huge potential within material and energy recovery systems and fits well into eco-industrial parks. The current study is a literature review that aims to evaluate the interest exhibited so far by scientific research in the topic of industrial symbiosis in the agri-food sector and to highlight the primary analytical techniques that have been used for this topic. Using the paradigm of multiple correspondence analysis, a content analysis was conducted from which the major themes of the researched phenomena emerged. The results indicate that the topic areas are unrelated and somewhat distant from each other. The analyzed case studies have revealed that the authors had neglected the communicative and collaborative elements among stakeholders, and instead focused on the potential use of some tools and approaches. Furthermore, it has been hypothesized that the hiding of information within a supply chain prevents industrial symbiosis procedures from being implemented. This research suggests the necessity of creating communication and cooperation platforms among stakeholders, which would promote the introduction of new techniques and tools for the development of circular production systems.
Co-application of biochar and compost with decreased N fertilizer reduced annual ammonia emissions in wetland rice
Authors: Ferdous J. , Mumu N. J. , Hossain M. B. , Hoque M. A. , Zaman M. , Müller C. , Jahiruddin M. , Bell R. W. , Jahangir M. M. R.
Published: January 2023

Ammonia (NH3) emission from rice fields is a dominant nitrogen (N) loss pathway causing negative impacts on farm profitability and the environment. Reducing N fertilizer application to compensate for N inputs in organic amendments was evaluated for effects on N lossviavolatilization, rice yields and post-harvest soil properties in an annual irrigated rice (Boro) – pre-monsoon rice (Aus) – monsoon (Aman) rice sequence. That experiment was conducted using the integrated plant nutrition system (IPNS; nutrient contents in organic amendments were subtracted from the full recommended fertilizer dose i.e., RD of chemical fertilizers) where six treatments with four replications were applied in each season: (T1) no fertilizer (control), (T2) RD, (T3) poultry manure biochar (3 t ha−1; pyrolyzed at 450°C) + decreased dose of recommended fertilizer (DRD), (T4) rice husk ash (3 t ha−1) + DRD, (T5) compost (3 t ha−1) + DRD, and (T6) compost (1.5 t ha−1)+ biochar (1.5 t ha−1) + DRD. The N lossviavolatilization varied twofold among seasons being 16% in irrigated rice and 29% in the pre-monsoon rice crop. In irrigated rice, T6had significantly lower NH3emissions than all other treatments, except the control while in pre-monsoon and monsoon seasons, T6and T3were alike. Pooling the three seasons together, biochar (T3) or biochar plus compost (T6) reduced NH3lossviavolatilization by 36-37% while compost alone (T5) reduced NH3loss by 23% relative to RD. Biochar (T3) and biochar plus compost mixture (T6) reduced yield-scaled NH3emissions by 40 and 47% relative to the RD of chemical fertilizer (T2). The organic amendments with IPNS reduced the quantity of N fertilizer application by 65, 7, 24, and 45% in T3, T4, T5, and T6treatments, respectively, while rice yields and soil chemical properties in all seasons were similar to the RD. This study suggests that incorporation of biochar alone or co-applied with compost and decrease of N fertilizer on an IPNS basis in rice-based cropping systems can reduce N application rates and NH3emissions without harming yield or soil quality.
Methods Matter: A Comparative Review of Health Risk Assessments for Ambient Air Pollution in Switzerland
Authors: Castro Alberto , Röösli Martin , de Hoogh Kees , Kappeler Ron , Kutlar Joss Meltem , Vienneau Danielle , Künzli Nino
Published: January 2023

Objectives: Air pollution health risk assessments (AP-HRAs) provide a method to quantify health effects for entire populations. In Switzerland, AP-HRAs are included in Swiss assessments for Transport Externalities (STEs), ordered by public authorities since the 1990s. This study aimed to describe the differences among national and international AP-HRAs for Switzerland.

Methods: We compared input data, approaches and results across AP-HRAs over time. Results and input data for each AP-HRA were expressed as a ratio compared to the most recent STE (in most cases STE-2010).

Results: Substantial variation across AP-HRAs was found. For all-cause adult mortality attributed to particulate matter (the most frequent outcome-pollutant pair), the ratio in HRAs oscillated from 0.40 to 2.09 (times the STE-2010 value). Regarding input data, the ratio ranged from 0.69 to 1.26 for population exposure, from 0 to 1.81 for counterfactual scenario, from 0.96 to 1.13 for concentration-response function and from 1.03 to 1.13 for baseline health data.

Conclusion: This study demonstrates that methods matter for AP-HRAs. Transparent and possibly standardized reporting of key input data and assumptions should be promoted to facilitate comparison of AP-HRAs.
Effect of Irrigation Management and Water Quality on Soil and Sorghum bicolor Payenne Yield in Cape Verde
Authors: Palacios-Diaz María del Pino , Fernández-Vera Juan Ramón , Hernández-Moreno Jose Manuel , Amorós Regla , Mendoza-Grimón Vanessa
Published: January 2023

Treated water use for agriculture will promote sustainable irrigation development and food sovereignty. The aim of this study is to assess the feasibility of subsurface drip irrigation (SDI) compared to drip irrigation (DI) and of reclaimed water (RW) versus conventional groundwater (CW), to produce forage sustainably in a warm arid region. A sorghum experiment was conducted in a field on Santiago Island (Cape Verde). A forage yield of 200 t fresh matter·ha−1·year−1, irrigated by RW, was obtained. Considering Cape Verde regulations, it is possible to irrigate sorghum using a drip system and RW without adding fertilizers. Soil fertility (OM and Ntot) increased, while risk parameters (EC, nitrate, and Na) returned to their initial values after the rainy season. The best irrigation water use efficiency was obtained by RWSDI (200 L·kg−1 DM) compared to RWDI, which needed 34% more water. According to the results, a high nitrate elimination rate in treatment plants might not be desirable if agricultural reuse is planned to irrigate high-N-demanding species. Establishing new salinity tolerance levels under reuse conditions with SDI, and irrigating in rainy months to promote the lixiviation of salts in arid regions are also necessary.
Infection Biology of Bipolaris oryzae in Rice and Defence Responses in Compatible and Less Compatible Interactions
Authors: Thuy Tran Thi Thu , Lübeck Mette , Smedegaard-Petersen Viggo , de Neergaard Eigil , Jørgensen Hans J. L.
Published: January 2023

The infection biology of Bipolaris oryzae and the defence responses of its host rice were studied using the rice cv. MTL 189 inoculated with two isolates of B5 (highly compatible with MTL 189) and K2 (less compatible). In the former interaction, the hyphal progress was accompanied by tissue degradation and extensive sporulation after 8 days, whereas in the latter interaction, only very limited tissue degradation and sporulation was observed. Quantitative microscopy of the infection showed that the percentages of conidia and appressoria causing penetration and fluorescent epidermal cells (FEC) were lower for isolate K2 than for isolate B5 at 12 and 24 hours after inoculation (hai). Fluorescent papillae (FP) were only seen in the less compatible interaction and the percentage of conidia causing single FEC was highest in the less compatible interaction at 12 hai, but not at 24 hai. Qualitative examination of other defence responses showed that H2O2 started to accumulate at 4 hai in the less compatible interaction, whereas it appeared in the compatible interaction only at 12 hai. The level of H2O2 was generally higher in the less compatible than in the compatible interaction. Cross sections of leaves showed that H2O2 accumulated in the outer walls of epidermal cells. Likewise, accumulation of callose and polyphenolic substances was most pronounced in the less compatible interaction and occurred at the same places as H2O2. To our knowledge, this is the first report implicating H2O2 as an early defence response against the hemibiotrophic pathogen B. oryzae during early infection stages in rice. Understanding defence reactions may aid in resistance breeding.
Beneficial Effects of Opuntia humifusa (Korean Cheonnyuncho) on Human Health Based on Antioxidant Properties: Systematic Review and Meta-Analysis
Authors: Ngoc Le Thi Nhu , Moon Ju-Young , Lee Young-Chul
Published: January 2023

In this study, a systematic review and meta-analysis are conducted to evaluate the medical applications of Opuntia humifusa (OH). A total of 171 articles are peer-reviewed; however, only 15 individual studies were included after the manual screening to eliminate unnecessary studies. A comparative standardized means difference (SMD) between the OH and control groups is used as a parameter to demonstrate the beneficial effects of OH for skin aging, cancer, and diabetes treatments based on its antioxidant activities. The OH treatment exhibits positive results in improving collagen synthesis and demonstrates that it is nontoxic to normal human cells without analytical heterogeneity (SMD = 1.18 [0.11, 2.26] and I2 = 0%). Moreover, the results confirm the effectiveness of OH treatment on downregulatory cancers in terms of decreased cancer cell proliferation and tumor weight and increased numbers of cancer cells in the apoptosis phase (pooled SMD = −1.17 [−1.72, −0.62]). However, this comparison does not yield a statistically significant result (I2 = 69%). Additionally, the OH treatment is found to reduce the symptoms of diabetes in diabetic rats, particularly by lowering glucose and triglyceride levels and increasing high-density lipoprotein cholesterol levels. This study suggests that OH extracts are helpful for the prevention of human diseases and might be potential candidates for future medicines.
Mitochondria-Targeted Triphenylphosphonium-Hydroxytyrosol Prevents Lipotoxicity-Induced Endothelial Injury by Enhancing Mitochondrial Function and Redox Balance via Promoting FoxO1 and Nrf2 Nuclear Translocation and Suppressing Inflammation via Inhibiting p38/NF-кB Pathway
Authors: Liu Xuyun , Gao Jing , Yan Yizhen , Georgiou Eleftheria A. , Lou Jing , Feng Mengya , Zhang Xing , Gao Feng , Liu Jiankang , Kostakis Ioannis K. , Zhao Lin
Published: January 2023

Hyperlipidemia results in endothelial dysfunction, which is intimately associated with disturbed mitochondrial homeostasis, and is a real risk factor for cardiovascular diseases (CVDs). Triphenylphosphonium (TPP+)-HT, constructed by linking a mitochondrial-targeting moiety TPP+ to hydroxytyrosol (HT), enters the cell and accumulates in mitochondria and is thus an important candidate drug for preventing hyperlipidemia-induced endothelial injury. In the present study, we found that TPP-HT has a better anti-inflammatory effect than HT. In vivo, TPP-HT significantly prevented hyperlipidemia-induced adverse changes in the serological lipid panel, as well as endothelial and mitochondrial dysfunction of the thoracic aorta. Similarly, in vitro, TPP-HT exhibited similar protective effects in palmitate (PA)-induced endothelial dysfunction, particularly enhanced expression of the mitochondrial ETC complex II, recovered FoxO1 expression in PA-injured human aorta endothelial cells (HAECs) and promoted FoxO1 nuclear translocation. We further demonstrated that FoxO1 plays a pivotal role in regulating ATP production in the presence of TPP-HT by using the siFoxO1 knockdown technique. Simultaneously, TPP-HT enhanced Nrf2 nuclear translocation, consistent with the in vivo findings of immunofluorescence, and the antioxidant effect of TPP-HT was almost entirely blocked by siNrf2. Concomitantly, TPP-HT’s anti-inflammatory effects in the current study were primarily mediated via the p38 MAPK/NF-κB signaling pathway in addition to the FoxO1 and Nrf2 pathways. In brief, our findings suggest that mitochondria-targeted TPP-HT prevents lipotoxicity induced endothelial dysfunction by enhancing mitochondrial function and redox balance by promoting FoxO1 and Nrf2 nuclear translocation.
Mitochondria in Cell-Based Therapy for Stroke
Authors: Monsour Molly , Gordon Jonah , Lockard Gavin , Alayli Adam , Borlongan Cesar V.
Published: January 2023

Despite a relatively developed understanding of the pathophysiology underlying primary and secondary mechanisms of cell death after ischemic injury, there are few established treatments to improve stroke prognoses. A major contributor to secondary cell death is mitochondrial dysfunction. Recent advancements in cell-based therapies suggest that stem cells may be revolutionary for treating stroke, and the reestablishment of mitochondrial integrity may underlie these therapeutic benefits. In fact, functioning mitochondria are imperative for reducing oxidative damage and neuroinflammation following stroke and reperfusion injury. In this review, we will discuss the role of mitochondria in establishing the anti-oxidative effects of stem cell therapies for stroke.
Investigation of Angle Measurement Based on Direct Third Harmonic Generation in Centrosymmetric Crystals
Authors: Li Kuangyi , Lin Jiahui , Zhang Zhiyang , Sato Ryo , Shimizu Hiroki , Matsukuma Hiraku , Gao Wei
Published: January 2023

This paper proposed angle measurement methods based on direct third harmonic generation (THG) in centrosymmetric crystals. The principles of the intensity-dependent and the wavelength-dependent angle measurement methods were illustrated. In this study, three prospective centrosymmetric crystals and two different phase-matching types were investigated in a wavelength range from 900 nm to 2500 nm. For the intensity-dependent method, a dispersion-less wavelength range was found from 1700 nm to 2000 nm for α-BBO and calcite. Compared with rutile, α-BBO and calcite had relatively better measurement performance based on the angle measurement sensitivity calculation. The wavelength-dependent method was considered in a dispersive range of around 1560 nm. The results suggested that α-BBO and calcite were also suitable for wavelength-dependent measurement. In addition, the effects of focusing parameters were considered in the simulation, and the optimized focal length (f = 100 mm) and the focused position (in the center of the crystal) were determined.
Reliability of Scores Computed by a Commercial Virtual Reality System and Association with Indices of Cognitive Performance in Male Elite Rugby Players
Authors: Vachon Adrien , Dupuy Olivier , Le Moal Corentin , Bosquet Laurent
Published: January 2023

Purpose: To examine the reliability of scores calculated from virtual reality (VR) games and their association with inhibitory control and cognitive flexibility in young elite rugby players. Methods: Following a familiarization session, seventeen rugby union players completed a session of a modified Stroop test and two sessions of three VR games consisting of (1) memorizing moving targets (Tracker Master); (2) selecting moving targets while avoiding pitfalls (Beat Master—Never Stop); and (3) selecting moving targets with an increasing frequency of appearance (Beat Master—Turbo). Results: The reliability of Beat Master—Never Stop was poor to moderate (0.41 < intraclass coefficient correlation [ICC] < 0.62; 3.2% < standard error of measurement [SEM] < 26.1%), while it was good to very good for Beat Master—Turbo (0.77 < ICC < 0.87; 3.2% < SEM < 18.2%). Regarding Tracker Master, reliability was considered as low to moderate (0.22 < ICC < 0.60; 2.2% < SEM < 6.0%). We found strong associations between Tracker Master and Stroop flexibility scores (−0.55 < r < −0.64), as well as strong to very strong associations between Beat Master—Never Stop scores and the Stroop inhibition score (0.52 < ∣r∣ < 0.84). Conclusions: Considering their metrological properties and their association level with inhibition and flexibility, the sensibility scores of the Beat Master—Never Stop and Tracker Master games should be preferred for monitoring training load, provided at least two familiarization sessions precede them.
Analysis of EMC Factors on Electronic Devices Using PLS-SEM Method: A Case Study in Vietnam
Authors: Duc Minh Ly , Bilik Petr
Published: January 2023

Electronic equipment is indispensable in the industrial 4.0 era. Electromagnetic Compatibility issues with electronic devices are increasingly concerning. The phenomenon of electromagnetic field compatibility is getting higher and higher. The operating quality of electronic equipment is more and more adversely affected, such as by the phenomenon of hesitation in operation for the operating structures, the generation of fire and explosion of electrical equipment, the loss of information, and many other negative effects. This paper discusses the relationship between Electromagnetic Compatibility (EMC) scoring, Electromagnetic Interference (EMI) scoring, and Electromagnetic Susceptibility (EMS) scoring with the performance quality of electronic devices (QUA). We perform reviews on regulatory institutions governing Electromagnetic Compatibility on electronic devices. To evaluate the proposed Electromagnetic Compatibility structure and its relationship to electronic devices, we proposed to use the Partial Least Squares Structural Equation Modeling (PLS-SEM) method. The research results of the model show that the electronic device layout conditions and the lack of systematic conditions have a negative impact on the operating quality of the electronic equipment, while the conditions on equipment techniques, scientific and technological resources have positive and significant impacts.
Formation Mechanism and Control Technology of an Excavation Damage Zone in Tunnel-Surrounding Rock
Authors: Fu Hongxian , Guan Xiaoming , Chen Chun , Wu Jianchun , Nie Qiqiang , Yang Ning , Liu Yanchun , Liu Junwei
Published: January 2023

Loosened rock circle is formed around the tunnel when the tunnel is constructed by the drilling and blasting method. The size of the loosened rock circle around the tunnel and the degree of internal rock fragmentation has an important influence on the support parameters, durability, and safety of the tunnel. Firstly, referencing an existing tunnel project, blasting tests using nonelectronic and electronic detonators were carried out to determine the influence of blasting construction on the scope of the rock loose circle and the degree of rock fragmentation. Then, a numerical simulation was used to study the contribution of the blasting impact and surrounding rock stress redistribution on the loosened rock circle around the tunnel. The results showed that the range of the loosened rock circle around the tunnel generated by the normal blasting of nonelectronic detonators was 1.5~2.3 m, and the wave velocity of the rock mass in the loosened rock circle around the tunnel decreased to 23~36%. The size of the loosened rock circle around the tunnel generated by the blasting impact was 0.66 m, accounting for 33% of the range of the loosened rock circle around the tunnel. The range of the loosened rock circle around the tunnel produced by electronic detonator blasting was 0~1.4 m. The wave velocity of the rock mass in the loosened rock circle around the tunnel decreased to 12~17%. The range of the loosened rock circle around the tunnel was approximately 60~76% of that of detonator blasting, and the broken degree of the surrounding rock in the loosened rock circle around the tunnel was small. The research results can provide a reference for the optimization design of preliminary support parameters of tunnels, such as anchors and steel arches in blasting construction.