bluuebunny/crossref_metadata_2025 huggingface dataset:
Analyzing movement behavior of zebrafish in different sized confined areas
Authors: Quach Kha Quang , Nguyen Quoc Anh
Published: November 2022

Movement behavior of zebrafish (Danio rerio) was analysed according to different sizes of observation arena (four sizes:and ). The observation arena was separated into corner, boundary and central areas based on experimental data. The results showed that the shapes of the corner, boundary and central areas were accordingly different in different sizes of the arena. Individuals stayed in the boundary zone for a substantial proportion (approximately 55-58 %) of the observation period while in the corner zone they stayed for the shortest time period (approximately 12-14 %). Movement parameters (speed, acceleration, etc.) of each individual varied in different areas on different sizes and speed was highest in the size of while acceleration was highest in the size of . These reveal that the movement behaviors of zebrafish were affected by different sizes of arenas, at larger sizes they move more actively compared to smaller sizes. However, Transition probability matrices (TPMs) of moving between different areas in the observation were stable. These findings imply that there is a stereotypic inner state that maintains basic behaviors in animals. Information from this work would provide backgrounds of real-life process mechanism and would be useful for monitoring in response to environmental changes in practical aspect and be applicable to a wide range of fields including pharmacology, neurology, and genetics.
Numerical simulation for determination of temperature field and residual stress of stainless steel butt joints with and without clamping
Authors: Nguyen Tien Duong
Published: November 2022

Many welded structures are fabricated from stainless steels because these steels have good mechanical properties and good corrosion resistance. It is necessary to predict the residual stress after welding in order to evaluate the performance of the welded joint. In this paper, the butt welded joint of AISI 316L stainless steel plates is studied. The Metal Inert Gas (MIG) welding process is selected for this material. A SYSWELD software based on the Finite Element Method (FEM) is used to determine the temperature field and residual stresses of two stainless steel plates. The welding simulation includes a sequential coupled thermomechanical analysis. The elemental generation and death technique is utilized to simulate metal deposition in welding. The double ellipsoidal heat source model is used for the heat input of the MIG welding process. The temperature distribution for various time steps at some important points is presented. Cooling times and cooling rates over a temperature range of 800 oC to 500 oC at these points are determined. The residual stress distribution in the longitudinal and transverse direction in two cases with and without clamping is obtained and compared. Obtained results show that: the temperature field in the case of clamping is the same as in the case of no clamping; only the longitudinal stress and transverse stress components are important, the other stress components are not important; the longitudinal stress at the middle of weld line is very high; the transverse stress in the case of clamping is greatly increased, so it is necessary to limit clamping to reduce residual stress after welding
Exploring antibacterial and cytotoxic potential of endophytic Streptomyces isolated from the medicinal plant Litsea cubeba (Lour.) Pers
Authors: Quach Ngoc Tung , Vu Thi-Hanh-Nguyen , Nguyen Thi Thu An , Bui Thi Lien , Le Thi Thanh Xuan , Phi Quyet-Tien
Published: November 2022

In the past decades, researchers and scientists have paid increasing attention to discover novel antibiotics and anticancer agents in combating infection and cancer diseases. It is believed that endophytic actinomycetes from medicinal plants provide a resourful niches for new compounds with significant bioactive properties. In the present study, we for the first time assessed antibacterial and cytotoxic activities of endophytic actinomycetes associated with Litsea cubeba (Lour.) Pers. A total of 25 endophytic actinomycetes were isolated from Litsea cubeba (Lour.) Pers collected at Lai Chau province, Vietnam, with the maximum number of isolates obtained from roots (44.4%), followed by stems (35.5%), and leaves (20.1%). Among them, 3 isolates LCL08, LCL25, LCL28 showed broad spectrum antibacterial activity against six pathogenic bacteria, which were subsequently identified as Streptomyces albogriseolus LCL08, S. olivaceus LCL25, and S. cavourensis LCL28 by using 16S rRNA sequence analysis. This is the first report of S. alborgriseolus isolated as endophyte. Ethyl acetate extracts from 3 strains exhibited strong antibacterial activity against 6 tested pathogens with the minimum inhibitory concentration value ranging from 2-64 μg/ml. Moreover, these extracts showed remarkable cytotoxic effects against Hep3B human hepatoma, MCF-7 breast cancer, and A549 lung cancer cell lines with the recorded viability of tested cancer cells ranging from 13.87 to 65.69%. These findings suggest that Streptomyces spp. recovered from Litsea cubeba (Lour.) Pers are an excellent source of natural antibacterial and cancer compounds that could be promising for further research.
Nature-derived Ultrahigh-performance Aromatic Bioplastics
Authors: Nag Aniruddha , Kaneko Tatsuo
Published: November 2022

Biomass, a renewable carbon source which can be processed using biorefinery system as an alternative of the conventional petroleum-based refineries. Aromatic precursor molecule synthesis involves chemical synthesis of fossil-fuel-based starting materials, such as benzene and xylene. These energy-intensive processes are usually producing many byproducts along with the desired molecule. If aromatic molecules can be extracted from natural resources involving minimum chemical conversions, that can be advantageous. Most of the reported approaches are expensive in nature and the outcomes with lower yield. Microbial fermentation of the lignocellulosic derivatives are ideal to establish sustainable society. In this chapter, we will focus on the aromatic building block preparations starting from nonedible feedstock such as kraft pulp. Aromatic aminobenzoic acid (3-amino-4-hydroxybenzoic acid) preparation from renewable resources and its use in various polymer preparations, such as polyaniline, polyester, and polybenzazole will be discussed here.
Comprehending Rationality as a Way of Spiritual Existence
Authors:   Yuri Gagarin State Technical University of Saratov, Dovgalenko Natalya
Published: November 2022

The actualization of the topic of rationality is caused not only by the scientization of the spheres of knowledge, life and activity, the emergence of techno-scientific reality on their basis, but also by the formation of a special type of consciousness on its basis. The author carries out a philosophical rethinking of the topic through the connection of rationality with the Greco-Roman doctrine of logos and the discovery of the image of the "subject". In this he is helped by two strategies of philosophy, founded by A. Badiou in the 21st century. The first one reveals the ratio structure, which is defined through the clarity of the boundaries of reflection (R. Descartes), the "doctrinal tradition" (M. Foucault), the "disciplinary matrix" (R. Rorty). Within these limits, spirit is subordinated to the system, regulations, being brought up through mentoring, transfer of meanings, values, methods. The second strategy links ratio with a radical transformation of a personality, "a complete reversal of existence," following not a strict hierarchy of learning, knowledge, but to the internal and external dialogue of a personality. The spiritual world of a man, within which rationality is grounded, changes by the 16th – 17th centuries as follows: 1) the self is transformed into subjectivity (sovereignty); 2) the practice of thinking, reading, writing (self-alienation, reflection) is established; 3) the process of cognition, existence is expressed through the procedure of domination (summing up under the ratio). Modo ("relevance"), which is revealed in the act of the subject's collision with himself as a "hypokemenon" – the basis through which all understanding and action is carried out, acquires a special significance. The type of consciousness based on rationality begins to reveal itself in activity, action, will. These methods substantiate a new inner selfunderstanding, a spiritual transformation of a person, not yet fully realized by modern culture.
Formation and Development of the Institutional System for Ensuring the Cultural Security of the Region
Authors:   Platov South Russian State Polytechnic University, Vodenko Konstantin
Published: November 2022

The purpose of the article is to study the cultural security of the South Russian region, taking intoaccount the relevance of this issue in the context of internal and external challenges in Russian society. The article contains conclusions about cultural security as an organic component of national and social security in the Russian regional space. It is noted that in the conditions of the need for social and political consolidation, the influence of risks in the field of culture increases as containing hidden conflict, but having the property of converting into social and political risks. The South of Russia as a multicultural education actualizes the model of cultural security at the level of preservation of cultural and historical heritage, continuity of traditions and innovations and prevention of cultural extremism. In the aspect of national security, the conflictogenic potential of cultural pluralism is noted, which is not only true for Western multicultural societies, but also has resonance in Russian regions, when cultural risks become obvious, determined by the closeness of cultural forms on the basis of the preservation, equivalence and immutability of cultural values, the main argument in favor of which is tradition. The institutional system of ensuring the cultural security of the South Russian region in a situation of internal and external challenges needs to mobilize the resources of state and public institutions. This is necessary to create a special platform that includes cooperation and dialogue, strengthening the forms of civil identity of the population based on the mechanisms of cultural heritage of historical memory. An equally important conclusion is that, as a consequence, it is necessary to block the channels of informal reproduction of cultural risks and imbalances, but this can be done through access to socio-informational and cultural resources of active groups of the population for whom associations of interests in the field of culture become the starting point in approving the goals of cultural security in the South Russian region.
“Precisamos de conocimientos para la vida, una universidad libre de colonialismo”.
Authors: Cariño Trujillo Carmen
Published: November 2022

El presente documento reflexiona en torno a la descolonización del saber y de las universidades a partir de la re­flexión del papel de las Conferencias como espacios de descolonización. Se reflexiona colocando en el centro el reconocimiento del lugar de enunci­ación de quien escribe y desde ahí se senti-piensa en torno a la importancia y urgencia de trabajar por la descoloni­zación más allá de las Conferencias y más allá de las Universidades. Se par­te de la idea de que la descolonización más que un discurso o una metáfora es una apuesta por la vida y con los pies en la Tierra. El colonialismo es hoy en día una realidad cotidiana y permanente que enfrentamos con más violencia los integrantes de pueblos racializados, pero es también desde esos lugares de resistencia donde están surgiendo reflexiones y acciones importantes hacia la descolonización. En este tex­to se analiza también el papel de lxs académicxs provenientes de pueblos indígenas y la crítica a la Universidad como lugar hegemónico de construcción del conocimiento.
Metadaten von Verlagen in Repositorien : eine Analyse und Auswertung der Datenlieferungen des Open-Access-Lieferdienstes DeepGreen
Authors:   , Stutz Sabrina
Published: November 2022

Open-Access-Publikationen gewinnen in Bibliotheken eine immer größere Bedeutung. Bibliotheken haben aufgrund verschiedener Lizenzierungsmodelle die Möglichkeit diese Publikationen auf ihren Repositorien zweit zu veröffentlichen. Um diesen Veröffentlichungsvorgang zu vereinfachen, bibliothekarische Bestände zu erweitern und die Arbeit der Bibliotheken zu automatisieren, gibt es den Open-Access-Lieferdienst DeepGreen. Er beliefert über 60 verschiedene Repositorien mit den Publikationen von mehreren Verlagen. Zur Weiterentwicklung des Lieferdienstes soll die Metadatenqualität verbessert werden, um den Aufwand für die beteiligten Repositorien weiter zu verringern. Die vorliegende Arbeit soll einen Einstieg für die Verbesserung der Metadatenqualität bieten. Neben einer Umfrage unter den DeepGreen Beteiligten werden auch die bisher vorliegenden Metadaten genauer beleuchtet. Hieraus werden Handlungsempfehlungen für die zukünftige Entwicklung der Metadatenqualität im Rahmen von DeepGreen erarbeitet.
Prevalência de uso de medicamentos em população rural brasileira
Authors: Mendes Samila Breder Emerich , Petarli Glenda Blaser , Cattafesta Monica , Zandonade Eliana , Bezerra Olívia Maria de Paula Alves , Mill José Geraldo , Salaroli Luciane Bresciani
Published: November 2022

Resumo Introdução Apesar da vulnerabilidade social existente na população rural brasileira, o uso de medicamentos entre agricultores é um tema ainda pouco estudado no país. Objetivo Analisar o uso de medicamentos e sua associação com características sociodemográficas, laborais, comportamentais e autoavaliação do estado de saúde em agricultores. Método Estudo epidemiológico transversal com 790 agricultores de 18 a 59 anos, de ambos os sexos, do município de Santa Maria de Jetibá. Os medicamentos foram agrupados segundo o Sistema de Classificação Anatômico-Terapêutico-Químico (ATC) nos níveis 1 e 2. Foram realizadas análise descritiva (frequências absolutas e relativas) e associações entre as variáveis e o uso de medicamentos pelo teste de qui-quadrado. As variáveis que se mostraram associadas com o desfecho com nível de significância de 5% no teste de qui-quadrado foram testadas por regressão logística binária. Resultados A prevalência de uso de medicamentos foi de 44,2%, sendo menor no sexo masculino (30,3%) do que no feminino (59,4%). Após a análise ajustada, o uso de medicamentos esteve associado ao sexo feminino, à faixa etária de 40 anos ou mais e à pior autoavaliação do estado de saúde. A prevalência de polifarmácia foi de 6,6%. Os medicamentos mais utilizados foram os anti-hipertensivos (19,3%). Conclusão O estudo evidenciou a importância de se avaliar populações rurais a fim de subsidiar políticas e recursos em saúde pública.
A necessidade de cuidado na percepção de pessoas idosas em processo de fragilização
Authors: Souza Gislaine Alves de , Giacomin Karla Cristina , Firmo Josélia Oliveira Araújo
Published: November 2022

Resumo Introdução Com o envelhecimento populacional faz-se necessário conhecer a percepção e experiência de pessoas idosas em processo de fragilização acerca de seu processo de cuidado. Objetivo Objetivou-se compreender a percepção de pessoas idosas em processo de fragilização sobre a necessidade de ajuda de terceiros para seu próprio cuidado. Método Trata-se de uma pesquisa qualitativa, ancorada na Antropologia Médica. A coleta dos dados ocorreu com participantes do estudo multicêntrico FIBRA (Fragilidade em Idosos Brasileiros), do polo de Belo Horizonte, Minas Gerais. Entrevistaram-se, no domicílio, 22 pessoas idosas em processo de fragilização, que tinham, em média, 79 anos. A análise êmica foi guiada pelo modelo dos Signos, Significados e Ações. Resultados Os signos evidenciam a inevitabilidade de depender dos outros: “não aguentar”, “não dar conta”, “não poder mais fazer”. Como indicativo da necessidade de ajuda surge: “ter que se limitar”, “ter que ter ajuda”, “ter que ter um acompanhante”. Assim, depender do outro aparece como um suporte essencial e se revela algo doloroso, invasivo, controlador, prenunciando a finitude. Diante disso, as pessoas idosas tentam adaptar-se às mudanças para manter certo grau de autonomia e independência, para sentir-se úteis, lançam mão de tratamentos diversos e têm fé. As desigualdades sociais influenciam as ações realizadas por esse público. Conclusão Observa-se a necessidade da solidariedade social e de políticas públicas comprometidas com o cuidado com a pessoa idosa em processo de fragilização, enquanto um sujeito sociocultural.
Effects of remote home-based exercise program on functional capacity and perceived loneliness in older adults during COVID-19 lockdown
Authors: Pontes Júnior Francisco Luciano , Villar Rodrigo , Santos Gabriela Ferreira dos , Zago Anderson Saranz , Beltrame Thomas , Bocalini Danilo Sales
Published: November 2022

Abstract Objective to determine the effects of a simple home-based exercise program on functional capacity and perceived loneliness of older adults in lockdown due to the COVID-19 pandemic. Method Twenty-nine volunteers were randomly divided into two groups: (1) control group (CG); and (2) home-based exercise group (HBEG). Lower limb muscle strength, functional capacity, and perceived loneliness were assessed at baseline (pre-test), 4 weeks, and 8 weeks (post-test) using the Chair Standing Test (CST), Gait Speed Test (GST), Timed Up and Go test (TUG), and Perceived Loneliness Scale (PLS). Results The number of repetitions on the CST differed statistically between the groups (CG vs. HBEP, p=0.006) and among timepoints (Pre vs. 4W vs. 8W, p=0.043.). In the CG group, TUG test completion time was statistically lower at baseline than at 8 weeks (p=0.021) (pre 12.0±5.9 s vs. 8W 12.7±6.5 s). There was no statistical difference in TUG time in the HBEG. No statistical differences were found on the GST and PSL between groups or among timepoints. Conclusion The home-based exercise program improved general functional capacity after 8 weeks of training, but perceived loneliness and gait speed were unchanged in the older adults experiencing lockdown due to the COVID-19 pandemic.
Perfil audiológico de indivíduos com síndrome de Cornelia de Lange: revisão integrativa da literatura
Authors: Santos Nayara Pereira , Silva Liliane Aparecida Fagundes , Kim Chong Ae , Matas Carla Gentile
Published: November 2022

RESUMO Objetivo: descrever o perfil audiológico de pacientes com Síndrome de Cornelia de Lange (SCdL), por meio de uma revisão integrativa da literatura. Métodos: após formulação da pergunta, realizou-se uma busca em seis bases de dados (Embase, ISI of Knowledge, Lilacs, Medline/PubMed, Scielo e Scopus), e fontes de informação (Google Acadêmico, OpenGrey e Proquest), com os descritores: audiologia, perda auditiva, surdez, transtornos da audição e Síndrome de Cornelia de Lange. Esta revisão foi cadastrada no Próspero, sob número CRD42020191481. Foram considerados para análise, estudos nacionais e internacionais, utilizando o direcionamento do acrônimo PECO. Para análise do risco de viés dos estudos, utilizou-se os protocolos do Instituto Joanna Briggs. Após isso, os estudos foram descritos e analisados. Resultados: dos 1.080 artigos encontrados, 12 atenderam aos critérios de inclusão. Nos resultados audiológicos, constatou-se que indivíduos com SCdL podem apresentar perda auditiva, sendo que o comprometimento pela perda auditiva condutiva foi o mais frequente, correspondendo a 49,20% dos indivíduos com SCdL avaliados, seguido pela perda auditiva neurossensorial (13,49%). O grau de perda auditiva variou de leve à profundo. Conclusão: indivíduos com SCdL frequentemente apresentam perda auditiva, decorrente principalmente de alterações de orelha média, com graus variando de leve a profundo.
Round multiprofissional com checklist: associação com a melhoria na segurança do paciente em terapia intensiva
Authors: Maran Edilaine , Matsuda Laura Misue , Magalhães Ana Maria Muller de , Marcon Sonia Silva , Oliveira João Lucas Campos de , Cavalcanti Alexandre Biasi , Haddad Maria do Carmo Fernandez Lourenço , Reis Gislene Aparecida Xavier dos
Published: November 2022

RESUMO Objetivo Verificar a associação entre round multiprofissional com uso de checklist e práticas de segurança do paciente por profissionais de saúde de uma unidade de terapia intensiva. Método Estudo de método misto, delineado pela abordagem sequencial explanatória, realizado em um hospital do sul do Brasil. Os dados quantitativos foram analisados por meio de regressão de Poisson e os dados qualitativos, pela análise de conteúdo. Fez-se a análise integrada por meio da combinação explicada/conectada. Resultados No período pós-implementação dos rounds com uso sistemático de checklist houve melhora significativa da profilaxia de tromboembolia venosa, sedação leve, redução dos dias de uso de ventilação mecânica, cateter venoso central e de sonda vesical de demora. Conclusão O round multiprofissional com uso sistemático de checklist, associado com a melhoria nas práticas de segurança do paciente, foi considerado como uma estratégia que assegura melhores cuidados em terapia intensiva e favorece a satisfação no trabalho.
Direito do Negro à Cidade: de uma Formação Socioespacial Racista à Utopia Lefebvriana
Authors: Rezende Ana Flávia , Andrade Luís Fernando Silva
Published: November 2022

Resumo O direito à cidade se manifesta como forma superior de direitos na participação e apropriação dos espaços urbanos. No presente texto, argumentamos que a população negra, tanto homens como mulheres, enquanto indivíduos e coletividade com uma cidadania mutilada, manifesta desvantagens cumulativas que a impede de exercer uma cidadania plena e disputar a cidade. Tal situação não aparece como fatalismo, uma vez que a resistência do povo negro é amplamente discutida na literatura de movimentos sociais. O objetivo deste artigo é propor desdobramentos entre o direito à cidade de Henri Lefebvre e a questão racial. Para tanto, apresentamos tópicos em que tratamos de direito à cidade e utopia, raça e interseccionalidade no contexto brasileiro e racialização do direito à cidade no Brasil. Concluímos que considerar a dimensão de raça, e sua intersecção com classe e gênero, no direito à cidade é espacializar a questão racial, uma vez que contemplar uma cidade lida a partir do viés racial apresenta não apenas relevância do ponto de vista acadêmico, mas enquanto exercício de desvelamento de realidades opressoras e parte do próprio contraespaço que é o direito à cidade.
Experiences and Social Processes of High School Students’ School Occupations in São Paulo
Authors: Ramos Rubia de Araujo
Published: November 2022

ABSTRACT In this paper we review the school occupation movements of São Paulo from the study of the discursive and action repertoires of the relevant players who were against the educational reform policy announced by the São Paulo State government in 2015. It aims to understand the struggle experience of the young players and part of their social processes. The article is divided into two parts: 1) a brief analysis of the educational policy and students’ disapproval and the support of public opinion, using the paradigm of communicative action; 2) reflection on intersecting themes such as feminism and gender equity issues, for example, that emerged within the social movement. The conclusion indicates that the experience of the occupations resulted in a greater complexity of the movement and its agendas.
Conectando Gestos e Imagens com Conceitos em Geometria
Authors: Leivas José Carlos Pinto , Mathias Carmen Vieira , Silva José Anchieta da
Published: November 2022

RESUMO A pesquisa teve como objetivo analisar como os estudantes identificaram conceitos, propriedades e relações de entes geométricos euclidianos, por meio de gestos com o uso de um jogo. A investigação caracteriza-se, quanto aos procedimentos técnicos, como uma pesquisa participante com abordagem qualitativa e foi realizada com alunos do Ensino Médio em uma escola privada. As análises realizadas, via categorização dos gestos utilizados, indicaram que os alunos produzem gestos de forma mais eficiente quando possuem uma imagem mental do ente geométrico a ser representado. A pesquisa também evidenciou que, aqueles que desempenham o papel de observadores no jogo, identificam o gesto produzido quando possuem conhecimento do conceito atrelado a ele.
Connecting Gestures and Images with Concepts in Geometry
Authors: Leivas José Carlos Pinto , Mathias Carmen Vieira , Silva José Anchieta da
Published: November 2022

ABSTRACT The research aimed to analyze how students identified concepts of Euclidean geometric entities, their properties, and relations, through gestures with the use of a game. The investigation is characterized, regarding technical procedures, as participant research with a qualitative approach and was carried out with high school students in a private school. The analyses performed, via categorization of the gestures used, indicated that students produce gestures more efficiently when they have a mental image of the geometric entity to be represented. The research also showed that those who play the role of observers in the game, identify the gesture produced when they have knowledge of the concept attached to it.
Educação Musical Escolar em Tempos de Militarização e Barbárie
Authors: Santos Micael Carvalho dos
Published: November 2022

RESUMO Este artigo discute o avanço do projeto de militarização nas escolas públicas brasileiras, contextualizando as implicações na educação musical escolar. Analisa-se o Programa Nacional das Escolas Cívico-Militares (PECIM) e apresenta-se os dados do Ministério da Educação para compreender o seu quadro, articulado com outras políticas educacionais. O artigo objetiva analisar o PECIM no contexto da educação musical escolar e suas perspectivas no contexto da formação humana. Assim, dialoga sobre a educação musical nesse cenário de organização escolar, destacando sua abordagem no currículo e possibilidades para o ensino de música nas escolas públicas. A educação musical escolar aberta e em consonância com o desenvolvimento humano pode contribuir para a compreensão da formação social e histórica da diversidade cultural existente no Brasil.
Parrhesiastic Aufklärung as Democratic Government of Self
Authors: Dalbosco Claudio Almir , Rossetto Miguel da Silva , Dutra Delamar José Volpato , Bertotto Claudio
Published: November 2022

ABSTRACT The dispute between modernity and postmodernity calls into question the emancipatory potential of reason and, to escape extremist positions on this, we argue that Foucault’s reading of the Kantian question of Aufklärung offers not only principles to critically mark out the advances and limits of modernity but also arguments to think about the human formation inherent to Aufklärung. For Foucault, the Greco-Roman heritage of the Kantian Aufklärung shows that his own historical ontology is a tributary of the philosophical-practical tradition linked to parrhesia-libertas, which posits culture and education beyond the negation of modernity as a whole. Therefore, formation implies understanding the world in which one lives and the dual human condition of minority and majority.
New Secondary Education: full-time schools policy analysis
Authors: Wathier Valdoir Pedro , Cunha Célio da
Published: November 2022

ABSTRACT This paper analyzes the Policy of Promoting Full-Time Secondary Schools, which prompts the Brazilian New Secondary Education to identify possibilities for ecosystemic education. Its theoretical basis is plural, based on complexity and governance. Methodology includes document analysis, survey with schools, and immersion in a school in the Brazilian Federal District. Based on critical discourse analysis, it concluded that there is room for self-eco-organization of local policies, indicating that reform does not take place in norms or resources but in people’s actions, in the context of practice. Failure to allocate financial resources and information can compromise sustainability.
Multi-objective calibration of Tank model using multiple genetic algorithms and stopping criteria
Authors: Gutierrez Juan Carlos Ticona , Caballero Cassia Brocca , Vasconcellos Sofia Melo , Vanelli Franciele Maria , Bravo Juan Martín
Published: November 2022

ABSTRACT Calibration of hydrologic models estimates parameter values that cannot be measured and enable the rainfall-runoff processes simulation. Multi-objective evolutionary algorithms can make the calibration faster and more efficient through an iterative process. However, the standard stopping criterion used to stop the iterative process is to reach a pre-defined number of iterations defined by the modeller. Alternatively, the Ticona stopping criterion is based on the minimum number of iterations required to achieve a determined number of non-dominated solutions in the Pareto front, resulting in a reduction of the computational time without losing performance during the calibration processes. We evaluated the Ticona stopping criterion in the Tank Model calibration. The calibration processes were performed using data from two river basins, with three genetic algorithms and two objective functions. The Ticona stopping criterion required a computational time 27.4% to 44.1% lower than using the standard stopping criterion and were obtaining similar results in simulated streamflow time series and similar values of the best set of parameters.
“The fight is ours”: the experience of caregivers of children with congenital zika syndrome
Authors: Junqueira Cora Coralina dos Santos , Collet Neusa , Vaz Elenice Maria Cecchetti , Bezerra Iolanda Carlli da Silva , Reichert Altamira Pereira da Silva
Published: November 2022

The study analyzed the experience of caregivers of children with congenital zika syndrome, both in family and social context. It is a qualitative study with ten caregivers of children with congenital zika virus syndrome, in a Pernambuco referral service for children with disabilities, from November 2018 to March 2019. Data were collected through semistructured interviews and interpreted by thematic analysis. Caregivers, especially mothers, dedicate themselves entirely to their syndromic children’s care, facing daily struggles in search of better living conditions, abandoning dreams, jobs, studies and facing financial difficulties as well as for the care of other children. Thus, health actions focused on the uniqueness of families are necessary to enable the offer and / or strengthening of support networks as well as to expand the possibilities for better living conditions for both women and their children with the syndrome.
Assessment of properties of ultra-high performance cementitious composites with glass powder waste
Authors: Soares Silvete Mari , Freitas Taís Oliveira Gonçalves , Oliveira Júnior Adalberto , Ferreira Fernanda Giannotti da Silva , Salvador Filho José Américo Alves
Published: November 2022

Abstract Novel developments on concrete technology such as high and ultra-high-performance concrete (HPC and UHPC) are notorious by its high consumption of Portland cement. Supplementary cementitious materials have been used as partial replacement of Portland cement aiming to minimizing clinker content, optimizing the use of binders, reducing CO2 emissions, and increasing durability. Waste glass powder could be an alternative due to its silica-rich nature and wide availability. This work aims to assess the influence Portland cement substitution by finely ground waste glass powder in contents of 10%, 20%, 30% and 50% on physical and mechanical behavior of ultra-high-performance cementitious composites (UHPCC). Results indicates the use of glass powder as substitution up to 50% of Portland cement does not significantly affect the analyzed properties at 28 days.
The Novel Diagnostic Index Based on HLA-DRB1 Genotype and PD-L1 Expression can Predict Severe irAEs in Patients with Metastatic Melanoma Taking Immune Checkpoint Inhibitors. The Results of the Pilot Study
Authors: Zhukova N. , Orlova R. , Malkova Anna , Kaledina E. , Demchenkova A. , Naimushina P. , Nazarov V. , Mazing A. , Lapin S. , Belyak N. , Shoenfeld Y.
Published: November 2022

Immune-related adverse events (irAEs) occur in up to 50% of patients treated with an anti-CTLA-4 antibody and 30% of patients treated with PD-1/PD-L1 antibodies. Severe forms of toxicity are observed in 3% of patients and require systemic steroid therapy and constant monitoring. One of the considered predictor biomarkers of irAEs development is HLA-genotypes. This research aims to evaluate the diagnostic significance of HLA-DRB1 genotypes and other clinical and laboratory parameters to predict the development of irAEs. The study involved 28 patients with metastatic melanoma taking checkpoint inhibitors therapy [nivo 53.6%, Ipi+nivo 32.1%, other (pembro, prolgo) 14.3%]. The PD-L1 expression and HLA-DRB1 genotype were evaluated. After 2-3 months the development of irAES was assessed. The complications of 3-4 grade or multi-organ damage were termed as severe irAEs. Various IrAEs developed in 57.1% (16/28) of patients, while severe irAEs occurred in 35.7% (10/28). Among all patients, HLA-DRB1 genotypes associated with the risk of autoimmune diseases were found in 78.5% (22/28). The PD-L1 expression was detected in 60.7% (17/28) of individuals. Combination treatment increases the risk of toxicity, p = 0.0028, with a diagnostic sensitivity of 56% and a diagnostic specificity of 100% (RR = 2.71, OR = 31.67). An index based on the parameters studied (HLA-DRB1, absence of PD-L1 expression, and type of treatment) was created. It allows assuming the risk of developing severe irAES (p = 0.0126). When comparing this indicator between irAEs 1-2 and irAEs 3-4, the presence of an index value of more than 2 gives a sensitivity for predicting severe toxicity of 40.00% and a specificity of 83.33%.
SOLAR TECHNOLOGY FOR METALLURGICAL WASTE PROCESSING
Authors: Paizullakhanov Mukhammad S. , Parpiev Odilhuja R. , Akbarov Rasuljan Yu. , Holmatov Abdurashid A. , Karshieva Nilufar H. , Cherenda Nikolai N.
Published: November 2022

The possibilities of solar installations based on mirror-concentrating systems for processing of waste materials in a stream of concentrated high-density solar radiation are analyzed. It is proposed to use mobile compact solar installations located near metallurgical plants for processing mining and metallurgical waste. The geometric and optical-energy parameters of the concentrator for processing are calculated in order to extract metals from mining wastes. It is shown that a system of mirrors consisting of a heliostat (100 m2) and a paraboloid-shaped concentrator with a diameter of 10 m can focus a solar radiation flux with a density sufficient to melt metallurgical waste from the Almalyk Mining and Metallurgical Plant (AMMP). It is shown that ultrasonic treatment of waste materials stimulates an increase in the amount of copper containing phase in the melt by 8 times compared to the initial state of the material.
The Macroeconomic Implications of CBDC: A Review of the Literature
Authors: Kim Kyungmin , Tetlow Robert J. , Infante Sebastian , Orlik Anna , Silva André F.
Published: November 2022

This paper provides an overview of the literature examining how the introduction of a CBDC would affect the banking sector, financial stability, and the implementation and transmission of monetary policy in a developed economy such as the United States. A CBDC has the potential to improve welfare by reducing financial frictions in deposit markets, by boosting financial inclusion, and by improving the transmission of monetary policy. However, a CBDC also entails noteworthy risks, including the possibility of bank disintermediation and associated contraction in bank credit, as well as potential adverse effects on financial stability. A CBDC also raise important questions regarding monetary policy implementation and the footprint of central banks in the financial system. Ultimately, the effects of a CBDC depend critically on its design features, particularly remuneration.
ESTIMATION OF NEUTRON AND PROMPT PHOTON DOSE RATE DISTRIBUTION IN TMSR-500 USING MCNP6
Authors: Pradana Luqman Satria , Utari Utari , Suharyana Suharyana , Khakim Azizul
Published: November 2022

Thorium Molten Salt Reactor-500 (TMSR-500), one of the Generation IV nuclear reactors, is designed by Thorcon International, Pte. Ltd, which is projected to be built in Indonesia. The reactor core is radially surrounded by B4C shielding, but not the upper part. As the silo hall sits above the reactor core and is accessible by reactor personnel, the dose rate must be calculated in the area to ensure the workers receive an annual dose below the acceptable limit. The dose rate from neutrons and photons as the result of fission reactions are the only sources to be calculated in this research, without taking the source from fission products into account. This research aims to obtain the dose rate distribution of neutrons and prompt photons using Monte Carlo code MCNP6. The reactor was assumed to operate at a nominal thermal power of 557 MWth. Dose rate calculation was obtained from flux Tally F4 and converted into dose rate using Dose Energy Dose Function (DEDF) factor. Conversion factors of flux to the dose were based on ICRP-21 and ANSI/ANS-6.1.1 1977. The result of the calculations showed that the distribution of neutron and prompt photon fluxes does not reach the silo hall.
PEMODELAN DINAMIK PENDINGINAN BAHAN BAKAR NUKLIR BEKAS REAKTOR RISET SECARA NATURAL KONVEKSI PADA PROTOTIPE DRY CASK STORAGE
Authors: Istavara Arifin , Ratiko Ratiko , Pratama Hendra Adhi , Nasruddin Nasruddin
Published: November 2022

PEMODELAN DINAMIK PENDINGINAN BAHAN BAKAR NUKLIR BEKAS REAKTOR RISET SECARA NATURAL KONVEKSI PADA PROTOTIPE DRY CASK STORAGE. Penelitian ini secara khusus bertujuan untuk menguji kelayakan desain dry cask storage dan secara umum memberikan solusi penyimpanan Bahan Bakar Nuklir Bekas (BBNB) di Indonesia. Karena keterbatasan ruang penyimpanan pada penyimpanan tipe basah, maka penelitian ini bertujuan untuk merancang, melakukan eksperimen  dan mensimulasikan secara simultan. Pengujian desain canister memvariasikan tegangan heater 50 V sampai dengan 125 V dengan kondisi tertutup untuk mengetahui respon canister terhadap tegangan yang sebanding dengan panas peluruhan BBNB. Eksperimen dengan menggunakan ventilasi dry cask storage memvariasikan tegangan 100 V sampai dengan 175 V bertujuan untuk menguji dry cask storage terhadap pendinginan canister secara natural konveksi. Perhitungan secara teori dan simulasi menggunakan software juga dilakukan sebagai pembanding hasil dari eksperimen dari segi pendinginan secara natural konveksi dan hambatan termal. Hasil eksperimen menunjukkan respon desain canister berfungsi dengan baik yaitu semakin besar tegangan listrik yang diberikan, maka temperatur canister bertambah tinggi, yaitu 50 V sampai 125 V merespon 33,4°C sampai 56,6°C. Pengujian pendinginan canister secara natural konveksi menunjukkan hasil yang baik, yaitu antara lain dengan metode buka dan tutup ventilasi dry cask menunjukkan penurunan temperatur canister pada tegangan 100 Volt  sebesar  16,1°C dan 14,8°C pada 125 Volt. Hasil nilai komparasi antara eksperimen, perhitungan teori dan simulasi pada 175 V temperatur canister yaitu 44,9°C, 49,7°C dan 65°C secara berurutan, untuk air velocity yaitu 0,20 m/s, 0,25 m/s dan 0,39 m/s secara berurutan. Hasil perhitungan teori dan simulasi sedikit lebih tinggi dari eksperimen, ini mungkin disebabkan adanya kehilangan panas ke lingkungan saat eksperimen berlangsung. Hasil simulasi diperoleh kontur temperatur dan perilaku aliran natural konveksi didalam air gap menunjukkan desain dry cask storage berfungsi dengan baik.Kata kunci : Bahan bakar nuklir bekas, natural konveksi, canister, dry cask storage.
Capacidad hospedante de tres especies de solanáceas de la sección Lasiocarpa al nematodo agallador de la raíz Meloidogyne incognita
Authors: Castro Quezada Patricio , Díaz Granda Lourdes , Pacheco Atariguana Luis
Published: November 2022

El nematodo del nudo de la raíz Meloidogyne incognita es una de las especies más peligrosas y comunes que afectan a las solanáceas, entre ellas la naranjilla Solanum quitoense. El objetivo de este trabajo fue evaluar el potencial reproductivo de un aislamiento de M. incognita en tres especies de Solanaceas en invernadero: Solanum sessiliflorum, Solanum hirtum (reportada anteriormente como resistente) y S. quitoense (susceptible). Plantas de las tres especies fueron sembradas en maceta y a las cuatro semanas fueron inoculadas con 2500 huevos más juveniles en estado 2 (J2). El inóculo inicial se obtuvo de raíces infestadas de plantas de S. quitoense recolectadas en huertos comerciales de naranjilla. Se utilizó un diseño experimental completamente aleatorizado. Las variables evaluadas a los 80 días después de la inoculación fueron: índice de agallas (GI), factor de reproducción de nematodos (RF), peso seco del área foliar, altura de la planta y diámetro del tallo. Se encontró que las tres especies mostraron agallamiento, pero S. sessiliflorum y S. hirtum mostraron el menor número de nudos de raíz con valores de 33,73 y 34,73. Además, S. sessiliflorum y S. hirtum presentaron una categoría de resistente/hipersensitivo con factores de reproducción de 0,94 y 0,85 (RF > 1) respectivamente, mientras que S. quitoense fue susceptible con un valor de 1,56. En términos de rendimiento de follaje (peso seco), altura de la planta y diámetro del tallo se observó una respuesta de tolerancia en S. sessiliflorum y S. hirtum en relación a S. quitoense.
Extended infusion of cephalosporins, penicillins and carbapenems: a cost-effective point-of-view and critical appraisal of Surviving Sepsis Campaign guidelines
Authors: Decker Sérgio Renato da Rosa , Marzzani Lucas Emanuel , Ferreira Pedro Rotta de
Published: November 2022

Narrative/ introduction. In the last edition of the Surviving Sepsis Campaign guidelines - SSC guidelines -   recommendations regarding the optimization of antibiotics pharmacokinetics and pharmacodynamics (PK/PD) were made. Among these, the use of extended infusion of beta-lactams (penicillins, cephalosporins and carbapenems), are proposed to improve clinical and microbiological outcomes. However, according to the authors, studies of the economic implications of extended infusion – cost-effectiveness studies – are needed for these recommendations.
Caveats. Sepsis represents a huge economic burden around the world due to the need for hospital and ICU beds, qualified staff and therapies for the treatment of the pathology, whereas it is known that antibiotics are the mainstay therapy. The basic research question for cost-effectiveness studies is to understand the superiority of a new and more expensive intervention over the "standard" therapy and, then, the implications of this in a health system and time perspective. However, extended infusion of antibiotics has shown a benefit in clinical outcomes and its use can reduce direct costs since is less expensive than the standard approach, considering that smaller amounts of the antibiotic are needed to reach the same PK/PD and clinical effect. Moreover, additional costs to do an extended infusion would not be significant, and more effective therapy could also reduce the indirect economic burden on the health systems. Therefore, it is beyond the scope of cost-effectiveness analyses, and should be incorporated by health systems.
Parallel detection of multiple effector functions in live T cells using a short coculture assay v1
Authors: Molvi Zaki
Published: November 2022

Assays measuring T cell effector function are powerful tools for determining the antigenic specificity of T cells. Conventional flow cytometric detection of cytokine production by T cells via intracellular staining necessarily compromises cell viability. In contrast, the use of a TNFa converting enzyme (TACE) inhibitor paired with monensin enables detection of both TNFa production and degranulation (CD107a/b) in viable T cells, enabling isolation of activated T cells by MACS or FACS for downstream applications such as cell culture or transcriptomic analysis. Herein, we describe the use of this assay to perform antigen rechallenge experiments in human T cells previously sensitized to antigen ex vivo.
Arabic lexicon in Sundanese language: An ethnolinguistic study on the pilgrimage ceremony of the indigenous people in Dukuh village
Authors: Qodim Husnul , Rohandy Fajar , Kurniawan Eri
Published: November 2022

The fact that a large number of Arabic loanwords exist in Indonesian-type languages has been public knowledge; however, the number of studies about the types of Arabic lexical items, and their meaning shifts particularly in the Sundanese language is surprisingly scant. To occupy such an empirical void, the present study explores the use of Arabic lexicon in Sundanese language variety spoken by the indigenous people of the Dukuh Village in Cikelet District, Garut Regency, Indonesia. Embracing an ethnolinguistic lens, this study sought to specifically examine the use of their Arabic lexicon, lexical meanings, contextual meanings, and cultural phenomena surrounding the use. A corpus from daily spoken interactions involving ten informants and monologs from elderlies in the Dukuh community serves as the data to be qualitatively analyzed. The results demonstrate that the Arabic loanwords appear in a relatively significant amount of their Sundanese language, 7.37% of the total words in the corpus. Some of the Arabic lexicons retain their meanings identical to those in the source language. However, some have been contextualized so that their meanings somewhat deviated from those of the source language. The Arabic words are evidently found in three main cultural phenomena, i.e., ideas, activities, and artifacts.
COMPLEX CHARACTERISTICS OF GEOLOGICAL/GEOTOURISTIC OBJECTS OF THE SKOLE BESKYDS AS INDICATORS OF TECTONIC-SEDIMENTARY PROCESSES IN THE OUTER CARPATHIANS
Authors:   Institute of Geology and Geochemistry of Combustible Minerals of the NAS of Ukraine, Lviv, Ukraine, Hnylko О. , Bogdanova М. ,   Lviv National University of Ivan Franko, Lviv, Ukraine, Bozhuk Т. ,   Ternopil Volodymyr Hnatiuk national pedagogical university, Ternopil, Ukraine
Published: November 2022

A description of the geological/geotouristic "weekend" excursion from Lviv to the nearest part of the Carpathians is presented with an overview of the exposed deposits of the Western European platform and the Skole Beskyds on the route Lviv - Mykolaiv - Verkhnye Synyovydne - Kamyanka - Lviv. A comprehensive outline of the geological position of the route area is given. The main geological objects and observation points (stops) along the route are described. The proposed route will allow you to get acquainted with the whole complex of the sediments on both the Tethys Paleocean margin and the ancient Paratethys Sea, to trace some indicators of the beginning of growth of the Carpathian Mountains, as well as to see the main oil-generating strata of the entire Carpathian arc. In observation points 1 and 2 near Mykolayiv, we observe Miocene shallow-water sandy formations of Paratethys. Point 3 is the Uhersk gas field located in the Carpathian Foredeep. In point 4 (Verkhnye Synyovydne) the lithofacies of the transition link between the Tethys and Paratetys deposits are exposed, and the Paratetys deposits here are expressed by the Menilite Formation (Oligocene) - the main oil-generating stratum of the Carpathians. In points 5 and 6 (Kamyanka Stream) we observe the deepest-water sedimentary formations of the Outer Carpathian segment of the Tethys – the products of catastrophic (including turbidite) currents and background (hemi)pelagic sedimentation.