bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of Blood Glucose Levels, Blood Pressure, Heart Rate and Oxygen Saturation among Diabetic Patients undergoing General Anesthesia and Local Anesthesia with Sedation: A Cross-Sectional Study
Authors: Moradi Farsani Darioush , Moghimi Zahra , Naghibi Khosrou , Azarnoush Hamed
Published: June 2022

Background: Due to the rapidly increasing prevalence of diabetes mellitus (DM), the number of patients undergoing surgery and therefore requiring anesthesia has become higher than ever. In this study we aimed to compare blood glucose levels and hemodynamic parameters of patients with and without overt DM who have received general anesthesia and local anesthesia with sedation for cataract surgery.
Methods: In this cross-sectional study, 120 patients with DM and 120 patients without DM were included. Each of these patients was randomly assigned to receive general anesthesia or local anesthesia with sedation. blood glucose levels and hemodynamic parameters were measured before surgery, 30 minutes after surgery and six hours after surgery.
Results: There was no significant difference between the four groups in terms of age, gender and duration of surgery (P > 0.05). Blood glucose levels didn’t differ between non-diabetic patients receiving general and local anesthesia before or at any time after surgery (P > 0.05). Blood glucose levels were higher in diabetic patients compared to non-diabetics before or at any time after surgery (P < 0.001). 30 minutes and six hours after surgery, blood glucose levels of diabetic patients receiving general anesthesia were significantly higher than diabetic patients receiving local anesthesia with sedation (P < 0.001). No significant difference was noted regarding blood glucose changes during the study time frames in any of the 4 study groups. Diabetic patients receiving general anesthesia had higher blood glucose levels compared to non-diabetics and diabetic patients receiving local anesthesia with sedation (p < 0.001). Before surgery, the four study groups did not differ significantly in SBP, DBP, HR, RR and O2 sat (P > 0.05DBP, HR and RR were not different among the study groups 30 minutes after surgery (P > 0.05). SBP, DBP, HR and RR were not different among the study groups six hours after surgery (P > 0.05).
Conclusion: Patients receiving general anesthesia should be monitored more closely to prevent anesthesia-induced respiratory depression. Using local anesthesia with sedation instead of general anesthesia can help prevent the detrimental effects of perioperative hyperglycemia in diabetic patients undergoing cataract surgery.
Comparison of Various Analgesic Protocols for Control of Postoperative Pain Following Anorectal Surgery
Authors: Rahimi Mojgan , Shamsi Afzal , Abdulmajeed Hasan Alaa
Published: June 2022

Background: Anorectal pathology is commonly perceived it and handled in common surgical practitioners’ fistula and abscess, hemorrhoids, fissures, condyloma, and other pathological conditions. Because of the strong sensory innervations of the canal of anal, patients endure severe discomfort during anorectal surgery. It is generally most severe in the first twenty-four hours especially after excisional hemorrhoidectomy. the aim of this study is a comparison between different analgesic protocols used to relieve pain postoperative anorectal surgery.
Methods: PubMed, Embase, Medline, Science Gate, Scientific Report, Elsevier, Google Scholar, and Cochrane Evidence Based Medicine Reviews were used to conduct a review search. Review of newly released books and papers with regard to the topic, as well as manual searches (Comparison of various analgesic protocols for control of postoperative pain following anorectal surgery), was started at (May,2021). we searched the published studies from 2011 to the present date by the full text:(various analgesic protocols post anorectal surgery).
Results: Anorectal surgery is marked by excruciating discomfort after the procedure. Using the new technique during anorectal surgery as hemorrhoidectomy to avoid more excision of anal mucosa and the skin, putting the suture nearest to the dentate line and away from the internal anal sphincter, and good hemostasis to avoid the inserting of the anal pack are the most essential methods to lessen pain postoperatively regardless of the type of anorectal surgery performed or the instrument to use during it. We found more protocols using multimodality pain management for the relief of pain, topical drugs that produce direct relaxation of the internal anal sphincter, topical intervention as a pudendal nerve block, a method of surgery as surgical sphincterotomy, and technical tips to reduce pain as ligasure.
Conclusion: Multimodal pain treatment has been demonstrated to minimize pain intensity and opioid doses in various kinds of surgery. According to the highest degree of proof, using current technological procedures and tools as a ligasure with some topical agent as GTN glyceryl trinitrate ointment provided amazing excellent alleviation of postoperative pain following anorectal surgery.
Anaesthetic Challenges in Children with Pierre-Robin Sequence: A Case Series
Authors: Ramachandran Haripriya , Venkataramaiah Bhagya Dammaningala
Published: June 2022

Pierre Robin sequence is associated with a triad of micrognathia, glossoptosis and airway obstruction. Securing the airway is of utmost importance in these patients. Use of vagolytic premedication, nebulisation with lignocaine to obtund airway reflexes, use of other airway devices (SGA) and equipment to assist in different airway scenarios helps in anaesthetising the patients.
SVC Syndrome in ICU: The Need of a Multidisciplinary Approach
Authors: Sandill Surabhi , Krishna Bhavya , Kohli Santvana , Jaiswal Binita
Published: June 2022

Superior vena cava (SVC) syndrome, a potentially life threatening medical emergency, occurs due to SVC obstruction caused by extrinsic compression, intrinsic stenosis or thrombosis.  Malignant mediastinal tumours account for more than 80% of cases of SVC syndrome. We hereby report a case of SVC syndrome who came with clinical features suggestive of SVC syndrome with dyspnea managed and diagnosed in the Intensive Care Unit with a multidisciplinary approach.
What Does the Meta-Analysis Tell Us about Aspirin and COVID Survival?: Aspirin and COVID-19 Mortality.
Authors: Varpaei Hesam Aldin
Published: June 2022

This Article Abstract is not Available.
A New Specific DNA Target Sequence for Identification of Staphylococcus epidermidis using Modified Comparative Genomic Analysis
Authors: Khoshbakht Reza , Zare Hosna , Kakhki Reza Kamali , Neshani Alireza , Arfaatabar Maryam
Published: June 2022

Background: Staphylococcus epidermidis (S. epidermidis) is the most frequently isolated pathogen from prostheses infections in the body. Therefore, improving its diagnostic methods, including rapid Nucleic Acid Amplification Tests (NAAT), seems necessary. Since the first step in designing a NAAT is to find a specific sequence and all DNA targets that have been introduced so far are not completely specific, we introduced a new 100% specific DNA target sequence to identify S. epidermidis in this study.
Methods: Modified comparative genomic analysis was used to find the best specific target sequence to detect S. epidermidis. A PCR method was designed for the evaluation of this target. To determine the detection limit and analytical specificity, pure genomic DNA of 18 bacteria include 12 standard strains (one S. epidermidis and 11 non-S. epidermidis) and six clinical isolates (five S. epidermidis and one non-S. epidermidis) were used.
Results: The 400 bp sequence of S. epidermidis ATCC 14990 was identified as the most specific sequence (Se400), having a 100% sequence similarity to S. epidermidis genomes but not with other bacteria. The detection limit of Se400-PCR was 10 fg, equal to about 4 copies of S. epidermidis genomic DNA/μl. All pure DNA templates from S. epidermidis generated a detectable amplicon by 264 bp length, but the PCR test was negative for the non-S. epidermidis group.
Conclusion: The Se400 sequence can be considered as a specific target for detecting S. epidermidis, based on our findings.
Impact of Single Nucleotide Polymorphism in the ANKRD55 Gene on Occurrence and Clinical Characteristics of Rheumatoid Arthritis
Authors: Salehi Rasoul , Motaghi Mina , Salehi Amirhossein , Karimzadeh Hadi , Pakzad Bahram
Published: June 2022

Background: Rheumatoid Arthritis (RA) has multifactorial etiology and numerous genetic and environmental factors have been related to an increased risk of RA. Recently, Genome-Wide Association Studies (GWAS) suggested a large number of Single Nucleotide Polymorphisms (SNPs) loci affecting the susceptibility to RA. One of these loci is rs6859219 (C>A), a functional polymorphism in the ANKRD55 gene which was associated with the expression of ANKRD55 and IL6ST. In the current study, we evaluated the possible association between rs6859219 (intronic variant) in the ANKRD55 gene with RA risk in the Iranian population.
Methods: A case-control study using 118 RA patients and 115 healthy counterparts was undertaken in order to determine rs6859219 genotypes using real‑time polymerase chain reaction High‑Resolution Melting (HRM) method.
Results: There was a significant difference in the genotype and allele frequencies of rs6859219 between patients and controls (p<0.001). Logistic regression analysis demonstrates that CC genotype and C allele increased the risk of RA (OR for CC genotype= 7.12; 95%CI [3.51-15.05]/ OR for C allele=4.16; 95%CI [2.78-6.28]). Furthermore, regarding the dominant and recessive model of inheritance, RA patients indicated obvious association of the rs6859219 variant compared to healthy controls (p<0.001). Moreover, in the patient group, there was a significant correlation between C-Reactive Protein (CRP) concentration with rs6859219 polymorphism (p<0.001).
Conclusion: Our findings propose a substantial correlation between rs6859219 polymorphism and RA risk and clinical characteristics of this disease in the Iranian population.
Evaluation of Serum Levels of MicroRNA-200C and ACE2 Gene Expression in Severe and Mild Phases of Patients with COVID-19
Authors: Sodagar Hadi , Khadem Ansari Mohammad Hasan , Asghari Rahim , Alipour Shahriar
Published: June 2022

The role of microRNA (miR)200c-3p in regulating ACE2 gene expression in viral and bacterial respiratory diseases has been established. Since ACE2 reduces the acute inflammatory effects in lung diseases and acts as a coronavirus receptor to invade the lung cells, this study investigates the relationship between miR-200c-3p and ACE2 expression in COVID -19 patients.
In this study, COVID-19 patients were divided into two groups: mild phase (PCR-positive and mild symptoms) and severe phase (PCR-positive with acute pulmonary symptoms and inflammation). Then, the subjects' demographic, clinical, and paraclinical characteristics were recorded using a prepared checklist. Total RNA was isolated from all samples according to the Trizol kit protocol to evaluate gene expression. Subsequently, the extracted product was analysed for miR-200c expression and ACE2 target gene expression by real-time PCR.
The results of the checklist data showed that smoking, cough, and the factors ESR and HCT were statistically significant between the two groups of patients in the mild and acute phases. Also, the mean expression of the miR-200c gene in the mild and acute patients was 1.87±0.70 and 1.87±0.62, respectively, which was not statistically significant. Still, the mean expression of the ACE2 gene, which was 3.96±0.76 and 3.28±0.52 in the mild and acute disease groups, respectively, showed a significant difference between the two groups.
This study showed that the expression levels of ACE2 were significantly reduced in people with severe inflammation compared to people with mild inflammation.
Immunosuppressive Effects and Potent Anti-tumor Efficacy of mTOR Inhibitor Everolimus in Breast Tumor-bearing Mice
Authors: Rostamzadeh Davoud , Haghshenas Mohammad Reza , Samadi Mahdi , Mojtahedi Zahra , Babaloo Zohreh , Ghaderi Abbas
Published: June 2022

To investigate the effects of everolimus, a mechanistic/mammalian target of rapamycin (mTOR) inhibitor, on tumor growth and immune response in a mouse model of breast cancer.
Human hormone receptor-positive (HR+)/human epidermal growth receptor 2-negative (HER2-) MC4-L2 cell line was used to establish a mouse model of breast cancer. The inhibitory effects of high (10 mg/kg) and low (5 mg/kg) doses of everolimus were investigated on tumor growth. Additionally, the frequency of CD4+Foxp3+ regulatory T cells (Tregs), CD8+Foxp3+ Tregs, and CD4+ and CD8+ T cells expressing cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) was explored by flow cytometry in bone marrow, lymph nodes, and spleen.
Our results showed that both 10 mg/kg and 5 mg/kg doses of everolimus efficiently inhibited tumor growth, resulting in reduced breast tumor volume. In addition, it was revealed that everolimus-treated mice induced a higher frequency of CD4+Foxp3+ Tregs, CD8+Foxp3+ Tregs, and CD4+Foxp3+CTLA-4+ Tregs as well as CD4+ and CD8+ T cells expressing CTLA-4 in their bone marrow, lymph nodes, and spleen compared with standard control (vehicle-treated) in a dose-dependent manner. Furthermore, we found that everolimus treatment with 10 mg/kg and 5 mg/kg increased the frequency of Helios+Foxp3+ Tregs in the bone marrow of treated mice compared with the control group.
Our results indicate that treatment with everolimus not only inhibits tumor growth but also exerts an immunomodulatory effect by inducing Tregs in the lymphoid organs of breast cancer-bearing mice. The combination of therapy with other anti-cancer agents may negate immune suppression and improve the efficacy of mTOR-targeted breast cancer therapy.
The Effect of Age and Cell Culture Parameters on the Quantity and Function of Bone Marrow-derived Dendritic Cells
Authors: Golara Maryam , Amiri Mohammad Mehdi , Moazzeni Seyed Mohammad
Published: June 2022

Dendritic cells (DCs) are a group of bone marrow-derived cells that play a crucial role in innate and acquired immune responses. Bone marrow-derived dendritic cells (BMDC) are used in many studies, so the efficiency and purity of the differentiated cells are essential. This study aimed to investigate the effect of several parameters, including the age of mice, cell culture medium, and swirling of the culture plate, to increase the efficiency of the induced cells, considering the standard protocols.
Bone marrow-derived dendritic cells were induced from both juvenile and adult mice bone marrow cells. Then, the purity of CD11c+ cells was compared between juvenile mice BMDCs and adult mice BMDCs. Cells were cultured in an enriched and non-enriched medium, and some wells were swirled when changing the medium on the 3rd day. Then the effect of enriched medium and swirling before medium replacement were evaluated based on the expression of the CD11c marker.
The efficiency of DCs differentiation (CD11c+ cells) was higher when juvenile mouse bone marrow precursors were used compared to adult mice; using the enriched media with supplements and swirling the well before media replacement significantly affected the purity of immature CD11c+ cells.
Due to our results, using juvenile mice, an enriched culture medium, and physical removal of granulocyte cells could significantly improve the purity and efficiency of CD11c+ cells. Therefore, considering these three items in the production protocol of these cells can probably reduce the use of lymphocyte-removing antibodies and purification methods.
The Clinical Approach Toward Hereditary Persistence of Fetal Hemoglobin: A Case Report
Authors: Ghaderi Afshin , Bakhtiari Tahereh , Jokar Saeid , Eshraghi Abbas
Published: June 2022

Fetal hemoglobin is the principal hemoglobin in the human fetus, and the adult levels of fetal hemoglobin (HbF) are less than 1% of total hemoglobin. A steady increase of HbF in patients with hereditary persistence of fetal hemoglobin (HPFH) is associated with complications. The present report describes HPFH in a 26-year-old man with emphasis on its hemoglobin electrophoresis. The patient was admitted with complaints of recurrent weakness and lethargy, weight loss, abdominal pain, and dyspepsia. Splenectomy was planned due to massive splenomegaly and gastrointestinal complications. Ultimately,  electrophoresis confirmed the diagnosis of HPFH.
Clinical Manifestation and Epidemiological Finding of Trichomonas vaginalis Infection in Unusual Areas of Body in Neonates: A Systematic Review
Authors: Taheri Mahdiyeh , Ghasemikhah Reza
Published: June 2022

Background: This study intends to increase awareness on the clinical and laboratory diagnosis as well as health care of newborns with trichomoniasis from infected mothers, to introduce this organism as a respiratory pathogen with lower prevalence in other areas, and to outline its manifestations and symptoms.
Methods: All case report articles in English language regarding the presence of T. vaginalisin unusual areas among infants, which were available in Scopus, PubMed, Science Direct, Google scholar, and Web of Science published between 1980 and 2021 were searched and reported by two independent researchers. Titles and abstracts of all articles were reviewed for initial screening.
Results: After searching the articles and evaluating their quality, 9 full text articles were selected. All reported cases were from 8 different cities (4 countries) in the world. In most cases, the parasite was in the respiratory tract, but it was also reported in the brain and urogenital tract. The most common clinical symptom was respiratory distress.
Conclusion: Although the possibility of trichomoniasis infection in unusual areas such as genitals is low, according to the reports collected from around the world, this parasite can also be present outside the genitals. Perhaps, reviewing trichomoniasis along with other diagnoses in these cases may lead to early diagnosis and treatment of the affected neonates.
Effects of Herbal Medicines on the Prevention and Treatment of Contact Dermatitis: A Systematic Review
Authors: Rastegar Sedigheh , Heydarirad Ghazaleh , Aryanian Zeinab , Shekofteh Maryam , Shahbodaghi Azam , Fahimi Shirin , Goodarzi Azadeh , Poshtmahi Sanaz
Published: June 2022

Background: Contact dermatitis (CD) is a common inflammatory disease of the skin. CD has a complex and multifaceted treatment, and one of the main components of CD treatment is inflammation management. We summarized the clinical trials exploring the effects of herbal medicine on patients with CD.
Methods: A systematic review was performed by searching four databases. Clinical trials in English investigating the effect of herbal medicines on CD prevention and treatment published from 2010 to 2020 were reviewed. This study was conducted based on the PRISMA guidelines.
Results: Nine clinical trials examining the effects of herbs on CD were identified. A total of 450 patients participated in these studies. Herbal medicines used in the reviewed studies were in various forms. Almost all the studies showed that these herbs were useful in preventing and treating CD. Regarding the side effects of the herbal medicines, few complications such as erythema and papules as well as positive chronotropic effects were reported.
Conclusion: Evidence showed that herbal medicines were effective in preventing and treating CD by reducing the inflammation level and increasing antioxidant defense. However, the number of clinical trials was low to draw definitive conclusions. Moreover, the studies were not homogeneous and differed regarding methodology, evaluation tools, and quality. Also, in these studies, the interactions and safety of the herbal medicines were not considered adequately. Therefore, well-designed evidence is required to draw definitive conclusions in this regard.
Turmeric for Treatment of Irritable Bowel Syndrome: A Systematic Review of Population-Based Evidence
Authors: Jafarzadeh Emad , Shoeibi Shahram , Bahramvand Yaser , Nasrollahi Elham , Maghsoudi Armin Salek , Yazdi Fatemeh , KarkonShayan Sepideh , Hassani Shokoufeh
Published: June 2022

Background: Irritable bowel syndrome (IBS) is a highly prevalent disorder of the gut interaction characterized by abdominal discomfort and pain associated with altered bowel habits in the absence of structural abnormalities. In spite of IBS' high prevalence and disease burden across the globe, no explanations have been given as to its underlying pathophysiology. As for the treatment of IBS, there is no specific medication, and the most beneficial treatment is usually supportive therapy. Recent animal and human studies have demonstrated the therapeutic potential of curcumin or turmeric in the treatment of IBS.
Methods: We systematically reviewed all available evidence supporting curcumin and turmeric's therapeutic potential in relieving IBS symptoms in the present study. For this purpose, a database search was performed using curcumin, turmeric, and IBS and all their equivalents as of the search terms in Web of Science, PubMed, Scopus, Ovid, Embase, and Google Scholar from1990 up to Feb 2021. The investigation was then limited to clinical trials, and then nine articles were collected for data analysis.
Results: The findings of the included literature showed that curcumin and turmeric alone or in combination with other medications could improve the severity of IBS as well as the quality of life among people who suffer from IBS symptoms.
Conclusion: Overall, medications containing curcumin and turmeric extract due to these compounds' anti-inflammatory effects may improve IBS symptoms, particularly abdominal pain and life quality.
Graft and Patient Survival Rate among Iranian Pediatric Recipients of Kidney Transplantation: A Systematic Review and Meta-Analysis
Authors: Shajari Ahmad , Ashrafi MohammadMoein , Shajari Hamideh , Derakhshan Ali
Published: June 2022

Background: The End Stage Renal Disease (ESRD) is irreversible impairment of renal function, to the extent that the patient becomes permanently dependent on alternative therapies, especially in children. We aimed to evaluate the graft and patient survival rate among iranian pediatric recipients of kidney transplantation through a systematic review and meta-analysis.
Methods: National (SID, MagIran, IranMedex, IranDoc) and international (Cochrane, Embase, ScienceDirect, Scopus, PubMed, and Web of Science) databases of, were searched to find studies published electronically from 1985 until Nov 2019. Heterogeneity between the collected studies was determined using the Cochran’s test (Q) and I2. Meta-regression was used to investigate the factors affecting statistical heterogeneity in 1, 5, and 10-year survival of kidney transplantation in addition to subgroup analysis based on cities.
Results: Ten studies were qualified to enter the meta-analysis. The total participants in the study were 2673 people with an average age of 13.71±3.65 years. In the random-effects model, the survival rate of 1, 3, 5 and 10 yr of kidney transplantation were 91, 88, 81 and 70%, respectively.
Conclusion: By providing the documented and comprehensive evidence, can be the basis of many plans, policies, and decisions of various sectors of development. These sectors include the evaluation of treatment programs and health interventions in the pediatric kidney transplantation. The results of the present study can provide an acceptable estimate of the survival rate of transplanted children in Iran and will be useful for planning prevention and treatment programs.
The Association between Suicidal Ideation and Albuminuria in Korean Adults
Authors: Choi Soo Jung , Nam Taehyun , Hwang In Cheol
Published: June 2022

Background: Data on the association between suicide and kidney function in the general population are scarce. This study evaluated albuminuria across suicidal ideation in Korean adults.
Methods: We performed a cross-sectional study using data from the 2011 to 2013 Korean National Health and Nutrition Examination Survey. Overall, 14,101 adults were included in an examination of the amount of albuminuria associated with suicidal ideation. Suicidal ideation was measured using a self-reported questionnaire and albuminuria was assessed using the urinary albumin-to-creatinine ratio (ACR).
Results: Various factors, including suicidal ideation, were associated with ACR. Multivariate regression analyses were stratified by age group and type 2 diabetes due to their strong relation to ACR. In the non-diabetic young group, individuals with suicidal ideation presented ACR 11.4 mg/g higher than those without suicidal ideation (P=0.038).
Conclusion: In healthy young people, suicidal ideation is associated with increased albuminuria.
Effect of Dapagliflozin Combined with Cognitive Behavior Training on Quality of Life and Cognitive Function in Elderly Patients with Type 2 Diabetes Mellitus Complicated with Mild Cognitive Impairment
Authors: Zhao Ying , Zhang Rui , Wang Su
Published: June 2022

Background: To investigate the effect of dapagliflozin combined with cognitive behavior training on quality of life and cognitive function in elderly patients with type 2 diabetes mellitus (T2DM) complicated with mild cognitive impairment.
Methods: Ninety-six elderly patients with T2DM and mild cognitive impairment treated in Shenzhen People’s Hospital, Guangdong Province China from June 2019 to December 2020 were selected and equally randomized into control group (CG) and experimental group (EG). The CG received conventional intervention, while the EG received dapagliflozin combined with cognitive behavior training based on the CG. The clinical observation indexes of both groups were compared to assess the clinical intervention effect of dapagliflozin combined with cognitive behavior training on elderly patients with T2DM complicated with mild cognitive impairment.
Results: After intervention, the blood glucose levels of both groups decreased, and compared with the CG, the blood glucose level of the EG was markedly lower (P<0.05). The scores of C-DMSES, ADL and MMSE of both groups were higher than those before intervention, and compared with the CG, the scores of the EG were obviously higher (P<0.05). The QOL-AD scores of both groups gradually increased, and compared with the CG, the QOL-AD scores of the EG were higher at 3 and 6 months after intervention (P<0.05).
Conclusion: For elderly patients with T2DM complicated with mild cognitive impairment, dapagliflozin combined with cognitive behavior training intervention can obviously improve their cognitive function, self-efficacy of diabetes management and quality of life, which should be promoted in clinic.
Factors Associated with Non-Adherence to Glaucoma Treatment in a Korean Nationwide Survey
Authors: Hwang In Cheol , Suh Heuy Sun , Choi Seulggie
Published: June 2022

Background: Glaucoma is a main cause of blindness despite the effectiveness of treatments, and adherence to treatment is a critical aspect of glaucoma management. We aimed to identify the factors associated with non-adherence to treatment among Korean glaucoma patients.
Methods: Data were collected from 4,833 glaucoma patients during the Korea Community Health Survey (KCHS) in 2008 and 2011 regarding current treatment for glaucoma, demographics, comorbidities, perceived health status, and health-related behaviors were subjected to analysis. A multivariable regression model was applied to identify factors related to non-treatment for glaucoma.
Results: Approximately, half of the 4,883 patients failed to adhere to treatment. Compared to the treatment group, the non-treatment group had lower social status, fewer comorbid conditions, were more optimistic about their health statuses, and more likely to adopt unhealthy behaviors. Stepwise regression analysis showed that poor social status (low level of education and unmarried), self-perception of a satisfactory health status, and unhealthy behaviors (smoking and no flu-vaccination) were significantly associated with non-adherent to treatment.
Conclusion: More attention should be paid to glaucoma patients with low social status or that are overconfident about their health. Future prospective studies that more comprehensively assess treatment compliance, are needed to confirm our findings.
Association between Indoor Environment, Blood Trace Elements, and Immune Globulin among Workers from Vegetables Plastic Greenhouses in Yinchuan, China
Authors: Li Honghui , Li Jiangping , Sun Wei , Dong Lijun , Zhu Lingqin , Jiang Zhen , Yang Huifang
Published: June 2022

Background: To study the association between indoor environment (MiE), blood trace elements (BTE), and immune globulin (PRO) among workers from vegetables plastic greenhouse, and to assess the mediate effects on MiE and PRO by BTE.
Methods: Overall, 168 practitioner and corresponding sheds were included from cross-sectional study in 2016. BTE and PRO were determined by physical test and MiE data from field and laboratory measurement. The association was assessed using canonical correlation analysis. The direct and indirect effects between MiE, PRO and BTE were conducted by structural equation model. 5000 times bootstrap methods were performed to estimate coefficient and 95% confidence interval.
Results: MiE was moderately correlated with BTE (canonical coefficient = 0.439), and BTE was strongly correlated with PRO (canonical coefficient = 0.514 and 0.481). No statistical evidence was found for the overall impact of MiE on PRO, and BTE as an intermediary affecting its relevance was not confirmed. Only the path way of the BTE impact on PRO had a significant positive effect (P=0.012).
Conclusion: BTE was positively associated with PRO, therefore, reducing exposure in greenhouse is a pathway to remain blood trace elements, and further effect the immune protein in human body.
Forecasting of Daily Outpatient Visits Based on Genetic Programming
Authors: Liu Xiaobing , Gu Fulai , Bai Zhaoyang , Huang Qiyang , Ma Ge
Published: June 2022

Background: The forecasting of daily outpatient visits has significant practical implications in outpatient clinic operation management, not only contributing to guiding long-term resource planning and scheduling but also making tactical resolutions for short-term adjustments on special days such as holidays. We here in propose an effective genetic programming (GP)-based forecasting model to predict daily outpatient visits (OV) in a primary hospital.
Methods: In the GP-based model, the holiday-based distance outlier mining algorithm was used to determine the holiday effect. In addition, solar terms were applied as the smallest unit to more accurately determine the impact of a change in the climate on the outpatient volume. A segmental learning strategy also was used to predict the daily outpatient volume for the time series data.
Results: The GP-based prediction could more effectively extract depth information from a finite training sample size and achieve a better performance for predicting daily outpatient visits, with lower root mean square error (RMSE) and higher coefficient of determination (R2) values, than the seasonal autoregressive integrated moving average (SARIMA) model in the time range of holidays and the holiday effect.
Conclusion: GP-based model can achieve better prediction performance by overcoming the shortcomings of the SARIMA model. The results can be applied to support decision-making and planning of outpatient clinic resources, to help managers implement periodic scheduling of available resources on the basis of periodic features, and to perform proactive scheduling of additional resources.
The Determinants of Undiagnosed Hypertension among Urban Community of Kuala Lumpur, Malaysia
Authors: Ibrahim Ariff Azfarahim , Abdul Manaf Mohd Rizal , Ismail Noor Hassim
Published: June 2022

Background: The prevalence of undiagnosed hypertension in Malaysia is 17.2%, which is higher compared to the known case of hypertension (13.1%) reported in 2015. For every two people diagnosed with hypertension, there will be three persons with undiagnosed hypertension; the trend has not changed since 2011. This study aimed to determine the determinants of undiagnosed hypertension among urban community of Kuala Lumpur, Malaysia.
Methods: This was a cross-sectional study conducted among 206 participants in Kuala Lumpur, Malaysia from the ongoing Prospective Urban Rural Epidemiology (PURE) project. The samples with complete variable data were taken from the second year of follow-up, starting Jan 2014 till Dec 2015, through convenience sampling. Data were analyzed using descriptive analysis, simple logistic regression, and multivariable logistic regression.
Results: Multivariable logistic regression showed that only four determinants were associated with undiagnosed hypertension which were the age group of 35 to 49 yr old (aOR: 5.9, 95% CI: 1.8; 19.1), secondary education level (aOR: 2.3, 95% CI: 1.1; 4.6), normal BMI (aOR: 5.1, 95% CI: 1.5; 16.6), and non-diabetes mellitus (aOR: 5.5, 95% CI: 2.5; 12.0).
Conclusion: The determinants of undiagnosed hypertension in this study showed that low-risk groups of hypertension were highly underdiagnosed. The low-risk group of hypertension was easily approached at their working place. Thus, routine health screening and awareness campaigns should be emphasized substantially at the working place to detect undiagnosed hypertension. Early detection will be beneficial as early management can be initiated to prevent further complications.
Effect of Narrative Therapy-Based Group Psychological Counseling on Internet Addiction among Adolescents
Authors: Gong Yingying , Gong Ning , Zhang Zhihui , He Yang , Tang Haiou
Published: June 2022

Background: There are a large number of psychological problems caused by Internet addiction. We aimed to explore the intervention effect of narrative therapy in combination with Pilates exercise on Internet addiction among adolescents.
Method: From July 2021 to October 2021, 42 adolescents with Internet addiction selected from four communities in Yiyang City of China were randomly divided into the intervention and control groups with 21 members in each group. The intervention group participated in the intervention of narrative therapy in combination with Pilates exercise eight times, whereas the control group did not receive any intervention. The 12-item General Health Questionnaire, Self-rating Young’s Diagnostic Questionnaire of Internet Addiction, and Positive Affect Subscale were used to measure the psychological indexes of the adolescents before and after the intervention.
Results: Compared with those in the control group, the adolescents in the intervention group had an obvious decrease in the degree of Internet addiction with a statistically significant difference before and after the intervention (P < 0.001). After the intervention, the intervention group had significantly higher mental health scores and significantly lower scores for anxiety, depression, social dysfunction, and loss of interest than the control group. After the intervention, the intervention group showed an obvious increase in the score for positive affect with a statistically significant difference before and after the intervention (P < 0.001).
Conclusion: The intervention method proposed in this study could effectively solve the problem of Internet addiction among adolescents.
IL-4, IL-10, TNF-α and IFN-γ Cytokine Levels in Patients with Cystic Echinococcosis and Fascioliasis
Authors: Beyhan Yunus Emre , Albayrak Cuneyt , Guven Irem
Published: June 2022

Background: Cytokines are protein substances involved in immune response and inflammation regulation, cell growth, tissue repair and natural and adaptive immunity events such as hematopoiesis. Changes in Th1 and Th2 immune responses provide information on the clinical presentation, pathology and diagnosis of diseases.
Methods: This study was conducted on 142 patients, aged 18-95 yr and applied to Parasitology Laboratory of Van Yuzuncu Yil Hospital between Aug 2018 and May 2019. Fifty-one of the patients were serologically diagnosed with CE, 53 with a diagnosis of fascioliasis, and 38 as the control group. Serum samples were taken from patients and levels of IL-4, IL-10, TNF α and IFN γ parameters were investigated by ELISA method. Results were evaluated by spectrophotometer and observed which immunologic parameters increased in which infections. Cytokine results were also evaluated according to patient age groups and genders. Chi-square and/or Fisher's exact test were used to evaluate the results. IL-4 response was detected in 50.9%; IL-10 in 44.2%; TNF-α in 43.3% and IFN-γ in 43.3% of CE seropositive patients.
Results: IL-4, IL-10, TNF-α and IFN-responses detected in 50.9%, 44.2%, 43.3% and 43.3% of CE patients, and in 43%, 39.2%, 34.4% and 40.6% of fascioliasis patients, respectively. The presence of Th1 and Th2 responses were detected in both infections. There was a significant relationship between fascioliasis and IL-4 response and between CE and IL-4, IL-10 and TNF-α responses (P≤.05).
Conclusion: These cytokine levels may provide information about the immune response to infections, and may be useful for early detection of disease and recurrence and monitoring of treatment.
Indicators of Intellectual Thinking as Healthy Thinking and Its Relation with Health-Promoting Lifestyle: A New Perspective in Clinical Psychology and Public Health
Authors: Javidi Nasir , Ghanei Mostafa , Ahmadi Khodabakhsh , Ahmadizadeh Mohammad Javad , Ebadi Abbas
Published: June 2022

Background: Quality of life is determined by the lifestyle of individuals. If people have a healthy lifestyle, then they have a higher quality of life. What makes a person's lifestyle is the way he thinks. Therefore, if the thinking is healthy, the person's lifestyle will be healthy, and if the thinking is unhealthy, the person's lifestyle will also be damaged, which will reduce the quality of life.
Methods: The research method was mixed method in two quantitative and qualitative phases. The research method in the qualitative phase was customary qualitative content analysis, in which the data analysis process was based on the approach of Granheim and Ladman. In the quantitative phase, the psychometric properties of the research scale were measured. This research was conducted from 2016 to 2021 in Iran. The statistical population in the qualitative section was all scientific texts in the form of articles, books and dissertations that were extracted from scientific databases such as ScienceDirect, PubMed, Elsevier, Ebsco, Sid, Magiran.
Results: Indicators of intellectual thinking have been mentioned as research results, which are the main components of the new model of thinking. Moreover, the level of thinking was mentioned and Cognitive distortions, cognitive bias, and perceptual errors were mentioned as sources of harm and error.
Conclusion: Intellectual thinking has been mentioned as healthy thinking, which is the main factor of a health promotion lifestyle because healthy lifestyle improves the quality of life of people, which is one of the indicators of public health. Therefore, a higher quality of life can be achieved from the model of healthy thinking, which is a new perspective on promoting public health.
A Novel and Rapid Isothermal Nucleic Acid Based Detection Assay of Vibrio cholerae by Polymerase Spiral Reaction (PSR) in Emergency Situations
Authors: Louhrasby Vahid , Mirhosseini Seyed Ali , Golmohammadi Reza
Published: June 2022

Background: The purpose of this survey was to develop a novel and rapid isothermal nucleic acid based detection assay of Vibrio cholerae by polymerase spiral reaction (PSR) in emergency situations.
Methods: The current study was conducted in Baqiyatallah University of Medical Sciences, Tehran, Iran in 2021. The conserved ctxA gene sequence of V. cholerae was used as a target of designed two pairs of primers. Amplification of nucleic acids performed under isothermal temperature of 65 oC in 55 min by using Bst DNA polymerase. PSR amplified products were real-time visualized under UV transilluminator and also on agarose gel electrophoresis.
Results: Seven non- V. cholerae bacteria were negative for detection, which indicated the specificity of PSR assay was 100%. A 10- fold serial dilution of V. cholerae genomic DNA was subjected to conventional polymerase chain reaction (PCR) and real-time PCR to compare their sensitivities with PSR. The detection limit of PSR was 3 × 10-5 ng/ μL within 60 min, which 100-fold higher than that of PCR (3 × 10-3 ng/μL), but the sensitivity of real-time PCR was found as same as it.
Conclusion: The PSR assay developed in this study can provide a simple, cost-effective, rapid, and precise diagnosis technique in endemic cholera outbreaks, especially in low-income with limited access provinces.
Risk Factors of Osteoporosis in Females: A Hospital-Based Case-Control Study, Yazd, Iran
Authors: Askari Maryam , Lotfi Mohammad Hassan , Azimi Mohammad , Ostovarfar Maral , Fallahzadeh Hossein , Mehrabbeik Akram , Hamedi Andishe
Published: June 2022

Background: The aim of this study was to evaluate the predictors of osteoporosis in women in Yazd, Iran.
Methods: This hospital-based case-control study was performed on 270 women 35-65 yr old (135 case and 135 control) from Mar 2016 to Mar 2017. Case and control were matched in terms of age ± 2 (year) as a group matching. Osteoporosis is defined as a T-score of bone mineral density (BMD) below –2.5 SD. Data were analyzed using SPSS 20 software. Statistical tests included chi-square, student t test and Mann Whitney test .Multiple logistic regression (MLR) which forward method was used for modeling.
Results: Odds ratio (OR) of osteoprosis were menarche age>12 yr (OR=3.37, CI:2.29-15.89), history of hysterectomy (OR=13, CI:3.81-44.82), rheumatoid arthritis (RA) (OR=6.58, CI:2.29-18.91) calcium supplements (OR=0.14, CI:0.04-0.41), menopause age <40 (OR=11.84, CI:1.54-90), second smoking (OR=3.38, CI:1.16-9.81) and increase of weight (OR=0.86, CI:0.80-0.94).
Conclusion: Predictors of osteoporosis was menarche age >12 yr (3 times), history of hysterectomy (13 times), RA (6.5 times), menopause age <40 (12 times), second smoking (more than 3 times), calcium supplements and weight (protective).
The Effectiveness of Transdiagnostic Treatment Program on Clinical Symptoms and Emotion Regulation in Girls Adolescents with Premenstrual Syndrome
Authors: Ghasemzadeh Sogand , Naghsh Zahra , Gholami Fesharaki Mohammad
Published: June 2022

Background: Premenstrual Syndrome (PMS) is the experience of some physical and psychological symptoms periodically in the last days of the menstrual cycle that interferes with academic, social and family functioning. We aimed to evaluate the effectiveness of Transdiagnostic Treatment Program (TTP) on clinical symptoms and emotion regulation in girl’s adolescents with PMS.
Methods: This experimental trial study was carried out on 32 girls adolescents with PMS referred to two medical centers located in Tehran, Iran from Mar 21, 2019, to Oct. The patients randomized in 2 groups, 1-intervention (n=16, 8 sessions, 90-minute weekly‎) and 2-control (n=10).The PMS Screening Tool (PSST) and Emotion Regulation Questionnaire (ERQ) before and after treatment were filled out by participant. The SPSS software and P<0.05 considered for data analysis and as significant levels respectively.
Results: The study sample was 32 girls adolescents with PMS (mean age intervention and control were 16.30±2.02 and 16.40±1.6, P=0.915). The score of two questionnaires, PSST (symptom, effect) and ERQ (cognitive reappraisal, suppression) between two groups in before treatment were the same. After intervention the change of variable symptom (-1.05 vs -0.02, P<0.001), effect (-0.53 vs -0.04, P<0.001), cognitive reappraisal (0.67 vs 0.02, P<0.001) and suppression (-0.64 vs -0.07, P<0.001) were significant between two groups.
Conclusion: TTP is an effective technique for controlling clinical symptoms and emotion regulation in girl’s adolescents with PMS.
Evaluation of the Predictors of the Quality of Life in the Postpartum Period: A Cross-Sectional Study
Authors: Mokhtaryan-Gilani Tahereh , Kariman Nourossadat , Sharif Nia Hamid , Ahmadi Doulabi Mahbobeh , Nasiri Malihe , Mokhtarian Gilani Tayebeh
Published: June 2022

Background: It is necessary to study the predictors of life quality in the early postpartum period. Early diagnosis, timely care and intervention can improve the health of mother and baby. We aimed to evaluate the predictors of the quality of life in the postpartum period.
Methods: This cross-sectional study was conducted on 407 eligible women aged 18 to 47 yr, in the postpartum period, selected from clinics affiliated with Shahid Beheshti University of Medical Sciences, Tehran, Tehran, Iran in 2018. Data were collected using a demographic and obstetric questionnaire and Maternal Postpartum Quality of Life (MAPP-QOL) with Cronbach's alpha coefficients of 0.96 to assess personal details and postpartum quality of life. Data analyzed using SPSS. Linear regression analysis was performed to examine the relationship between maternal predictors and quality of life in the postpartum period.
Results: The postpartum quality of life had a significant relationship with income status (P<0.001), Number of Children (P=0.031), mother's education(P=0.009) and maternal complications (P<0.001).
Conclusion: This study confirmed the relationship between maternal predictors and the postpartum quality of life. It could facilitate clinicians and educators to improve the quality of life for postpartum women.
Sero-Epidemiological Study of Human Hydatidosis in Semnan and Sorkheh, Semnan Province, Iran
Authors: Hafezi Fatemeh , Mohammadzadeh Tahereh , Pazoki Ramin , Ahmadi Ranani Kazem , Sadjjadi Seyed Mahmoud
Published: June 2022

Background: To determine the seroprevalence of human cystic echinococcosis/hydatidosis which is one of the most important zoonotic diseases by ELISA using native antigen B in Semnan and Sorkheh, Semnan province, Iran, where no significant information about human infection exists.
Methods: Overall, 957 human serum samples were randomly prepared from Semnan, Sorkheh, and its 13 surrounding villages in different seasons from 2017 to 2018. Antigen B was prepared from native hydatid cyst fluid of domestic sheep. All serum samples were evaluated by ELISA while the suspected cases were rechecked. The cut-off was calculated as the X̄±2SD.
Results: Overall, 48(5%) out of 957 (422 males and 535 females) were positive for hydatidosis. The seropositivity based on sex showed 20(2.1%) out of 422 in males and 28(2.9%) out of 535 in females. The distribution of seropositive samples based on residence area showed 41 (4.3) out of 882 in urban and 7 (0.7) out of 75 in rural areas. The highest seroprevalence cases was among housewives (2.1%) followed by employers (1.5%). Based on education, source of drinking water, and age groups the highest seropositivity was observed in high school and less, in the plumping water consumers, and 50 to 59 yr old age group, respectively. There was a significant difference between seropositivity with occupation, literacy, and age group (P<0.05). Semnan with 4% seropositivity had the highest prevalence followed by Sorkheh, county.
Conclusion: High prevalence of the disease in this area emphasizes the importance of increasing people's awareness about hydatidosis.
Worst Socioeconomic Outcome Still Increase the Prevalence of Dental Caries in Pre-Schools of a Municipality of Great Port in the South Brazil
Authors: Bruzamolin Carolina Dea , Gaio Daniella Cristina , Paiva Bertoli Fernanda Mara de , De Souza Juliana Feltrin , Losso Estela Maris , Pizzatto Eduardo , Brancher João Armando
Published: June 2022

The Article Abstract is not available.
Sex Determination through 3D Analysis of the Maxillary Sinus
Authors: Jeon Eun-Young , Ahn Hyun-Na , Park Jong-Tae
Published: June 2022

The Article Abstract is not available.
Objective Assessment of Countries’ National Action Plans on Antimicrobial Resistance
Authors: Lee Jung Hun , Kim Tae Yeong , Jang Kyung-Min , Jeon Jeong Ho , Kim Young Bae , Jeong Byeong Chul , Lee Sang Hee
Published: June 2022

The Article Abstract is not available.
Response Comment on “Chlamydia Infection as a Risk Factor for Cervical Cancer: A Systematic Review and Meta-Analysis”
Authors: Pillai Anaanthan Bhuvanendran , Safian Nazarudin
Published: June 2022

The Article Abstract is not available.