bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of Hepatocellular Carcinoma in Men and the Contribution of
Androgen and its Receptor in Pathogenesis and Therapy
Authors: Abdel-Hamid Nabil Mohie , Al-Quzweny Rawaa Muayad
Published: October 2022

Background:

Hepatocellular carcinoma (HCC) is a solid cancer with high predominance
in males. Liver tissue of both genders has saturable specific oestrogen receptors. Androgen and its
receptor (AR) have been suggested to contribute to the predominance in men. Anti-oestrogens, like
tamoxifen may reduce the expression of oestrogen receptors, sustaining cellular in HCC. In vitro
and human, studies confirmed that both testosterone and dihydrotestosterone (DHT) enhanced the
growth and proliferation of hepatic normal and tumour cells. Although the activity of AR is escalated
by the chemical induction of hepatocarcinogenesis; clinical trials with AR-targeted agents alone
failed to generate survival benefits.

Purpose:

This review will outline the possible pathophysiological mechanisms by which both androgen
and AR contribute to hepatocarcinogenesis and to which extent this pathway can be responsible
for the male prevalence and if they could be pharmacological targets in HCC management.

Conclusion:

Influencing factors that seem to be responsible for male prevalence include testosterone,
dihydrotestosterone and androgen receptors, as well as, proteomic deficiency of DNA packaging,
nuclear proteins and homeostasis-related functional proteins. Understanding the reasons for
males, rather than females the HCC prevalence may help in suggesting new approaches by improving
the anti-AR therapies through co-targeting of AR and protein kinase B (Akt)/mammalian target
of rapamycin (mTOR) pathway.
Revisión sistemática sobre tipos de sustratos utilizados en la propagación de orquídeas bajo invernadero
Authors: Bello Castañeda Natali , Coy Barrera Carlos Andrés , Perez María Mercedes
Published: October 2022

Las orquídeas son una familia de plantas que se distinguen por la complejidad, la belleza de sus flores, las interacciones ecológicas con hongos y polinizadores, por su adaptabilidad en diferentes ambientes y por su amplia diversidad. Existen más de 25 000 especies se han reportado a escala mundial, y Colombia es uno de los países que cuenta con el mayor número de especies de orquídeas: se considera que hay 4 400 especies agrupadas en 274 géneros. El aumento en la demanda comercial legal e ilegal de orquídeas como productos ornamentales ha dado como resultado un mayor interés en el desarrollo de métodos de propagación masiva no solo para su comercialización, sino para su conservación. Por ello, resulta interesante identificar cuáles son los tipos de sustratos utilizados en invernadero para la producción de orquídeas provenientes de cultivo in vitro, a través del análisis de estudios en los cuales se caracterizan los materiales utilizados de acuerdo con el porcentaje de supervivencia de las plantas en el proceso de aclimatación y endurecimiento, etapa en la cual se realiza el trasplante de laboratorio a condiciones de invernadero, así como las implicaciones que presentan a nivel de metabolismo secundario durante diferentes etapas de desarrollo.
Sistematización de experiencias de jornadas de limpieza de playas en un área marina protegida como estrategia de educación ambiental
Authors: Henao Castro Alejandro , Vives Hutado Martha Patricia , Valcárcel Castellanos Camilo Alberto , Salcedo Oviedo Claudia Patricia , Torres Amaranto Daisy , López Paternina Guido , Cely Herrera Cesar Andrés
Published: October 2022

En el Parque Nacional Natural Los Corales del Rosario y de San Bernardo, se identificaron amenazas que afectan la biodiversidad de sus ecosistemas, destacando la acumulación de residuos sólidos plásticos en litoral de playa arenosa. Por tanto, desde hace más de una década se realizan jornadas de limpieza como estrategia de educación ambiental en articulación con diferentes actores locales. Basado en lo anterior, este estudio se propuso sistematizar las experiencias de ocho jornadas de limpieza de litoral con el fin de identificar aprendizajes adquiridos, sensibilización y concienciación hacia la conservación, así como las lecciones aprendidas en la organización de estas. La sistematización se realizó a partir de un análisis documental, entrevistas semiestructuradas y relatos de experiencia de participantes en las jornadas. Los resultados muestran los aportes que generan las jornadas de limpieza en la conciencia ambiental, sin embargo, es indispensable que sean constantes y se articulen con otras actividades educativas para generar procesos de cambio de actitudes y una cultura ambiental.
Efecto de la solarización en patógenos fungosos que afectan al Eucalipto (Eucalyptus urograndis) en condiciones de vivero
Authors: Ruiz Díaz Mariana , Campo Arana Rodrigo Orlando , Royet Barroso Jhoandys De Jesús
Published: October 2022

Eucalyptus es el género de árboles de madera dura más cultivado mundialmente, valorado por su rendimiento y la calidad de la madera para múltiples usos; sin embargo, los patógenos como Rhizoctonia y Cylindrocladium ponen en riesgo el establecimiento del cultivo, debido a que causan muerte de plántulas en vivero. Dentro de las estrategias de manejo se recomienda la desinfección del sustrato, siendo la solarización una alternativa eficaz para el manejo de hongos del suelo. El objetivo de esta investigación fue verificar la sobrevivencia de Rhizoctonia spp. y Cylindrocladium spp. en un sustrato de vivero sometido a solarización. El sustrato fue inoculado con dos aislamientos fúngicos (Rhizoctonia spp. y Cylindrocladium spp.) a tres profundidades (5, 10 y 15 cm), y tratados con tres métodos de solarización (Libre exposición, solarización y solarización + dazomet). Se midió la sobrevivencia de los patógenos en el sustrato a los 15, 30 y 55 días después de la inoculación, y la temperatura a 10 y 15 cm de profundidad. La solarización por sí sola no tuvo efecto sobre la mortalidad de los patógenos. La solarización más dazomet disminuyó la presencia de los hongos en un 100% en todos las profundidades y tiempos de evaluación. Los tratamientos solarizados aumentaron la temperatura del sustrato en 49 y 40°C a 10 y 15 cm de profundidad, respectivamente, con un incremento de 10 y 7°C respecto al testigo. Por tanto, la solarización más la aplicación de dazomet puede emplearse como método de desinfección de sustratos en vivero de Eucalipto.
The Effects of Virtual Reality in Maternal Delivery: Systematic Review and Meta-analysis
Authors: Xu Nuo , Chen Sijing , Liu Yan , Jing Yuewen , Gu Ping
Published: October 2022

Background

Extreme labor pain has negative effects; pharmacologic analgesic modalities are effective but are accompanied by adverse effects. Virtual reality (VR) works as a distracting nonpharmacologic intervention for pain and anxiety relief; however, the effects of VR use in laboring women is unknown.

Objective

Our study aimed to determine the safety and effectiveness of VR technology during labor and delivery and investigate whether it impacts labor and patient satisfaction.

Methods

In all, 7 databases (PubMed, Embase, Web of Science, the Cochrane Library, CINAHL, China National Knowledge Infrastructure, and Wan-Fang Database) were systematically searched for randomized controlled trials of VR use in pregnancy and childbirth from the time of database construction until November 24, 2021. Two researchers extracted data and evaluated study quality using the Cochrane Risk of Bias tool 2.0. Outcome measures were labor pain, anxiety, duration, satisfaction, and adverse events. Meta-analyses were performed where possible.

Results

A total of 12 studies with 1095 participants were included, of which 1 and 11 studies were rated as “Low risk” and “Some concerns” for risk of bias, respectively. Of the 12 studies, 11 reported labor pain, 7 reported labor anxiety, and 4 reported labor duration. Meta-analysis revealed that VR use could relieve pain during labor (mean difference –1.81, 95% CI –2.04 to –1.57; P<.001) and the active period (standardized mean difference [SMD] –0.41, 95% CI –0.68 to –0.14; P=.003); reduce anxiety (SMD –1.39, 95% CI –1.99 to –0.78; P<.001); and improve satisfaction with delivery (relative risk 1.32, 95% CI 1.10-1.59; P=.003). The effects of VR on the duration of the first (SMD –1.12, 95% CI –2.38 to 0.13; P=.08) and second (SMD –0.22, 95% CI –0.67 to 0.24; P=.35) stages of labor were not statistically significant.

Conclusions

VR is safe and effective in relieving maternal labor pain and anxiety; however, due to the heterogeneity among studies conducted to date, more rigorous, large-scale, and standardized randomized controlled trials are required to provide a higher-quality evidence base for the use of VR technology in maternal labor, with the aim of improving experience and outcomes.

Trial Registration

PROSPERO CRD42021295410; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=295410
Underestimated Prevalence of HIV, Hepatitis B Virus (HBV), and Hepatitis D Virus (HDV) Triple Infection Globally: Systematic Review and Meta-analysis
Authors: Chen Sisi , Ren Feng , Huang Xiaojie , Xu Ling , Gao Yao , Zhang Xiangying , Cao Yaling , Fan Zihao , Tian Yuan , Liu Mei
Published: October 2022

Background

Hepatitis delta virus (HDV) is a satellite RNA virus that relies on hepatitis B virus (HBV) for transmission. HIV/HBV/HDV coinfection or triple infection is common and has a worse prognosis than monoinfection.

Objective

We aimed to reveal the epidemiological characteristics of HIV/HBV/HDV triple infection in the global population.

Methods

A systematic literature search in PubMed, Embase, and the Cochrane Library was performed for studies of the prevalence of HIV/HBV/HDV triple infection published from January 1, 1990, to May 31, 2021. The Der Simonian-Laird random effects model was used to calculate the pooled prevalence.

Results

We included 14 studies with 11,852 participants. The pooled triple infection rate in the global population was 7.4% (877/11,852; 95% CI 0.73%-29.59%). The results of the subgroup analysis showed that the prevalence of triple infection was significantly higher in the Asian population (214/986, 21.4%; 95% CI 7.1%-35.8%), in men (212/5579, 3.8%; 95% CI 2.5%-5.2%), and in men who have sex with men (216/2734, 7.9%; 95% CI 4.3%-11.4%). In addition, compared with people living with HIV, the HIV/HBV/HDV triple infection rate was higher in people with hepatitis B.

Conclusions

This meta-analysis suggests that the prevalence of HIV/HBV/HDV triple infection in the global population is underestimated, and we should focus more effort on the prevention and control of HIV/HBV/HDV triple infection.

Trial Registration

PROSPERO CRD42021273949; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=273949
How Face Masks Affect the Use of Echolocation by Individuals With Visual Impairments During COVID-19: International Cross-sectional Online Survey
Authors: Kreidy Chantal , Martiniello Natalina , Nemargut Joseph Paul , Wittich Walter
Published: October 2022

Background

Although a critical safety measure, preliminary studies have suggested that the use of a face mask may pose a problem for some users with disabilities. To date, little is known about how the wearing of a traditional face mask may pose a barrier to individuals with visual impairments who draw on auditory cues and echolocation techniques during independent travel.

Objective

The goal of this study was to document the difficulties, if any, encountered during orientation and mobility due to the use of a face mask during the COVID-19 pandemic and the strategies used to address these barriers.

Methods

In total, 135 individuals aged 18 years and older who self-identified as being blind, being deafblind, or having low vision and who could communicate in either English or French completed an anonymous cross-sectional online survey between March 29 and August 23, 2021.

Results

In total, 135 respondents (n=52, 38.5%, men; n=83, 61.5%, women) between the ages of 18 and 79 (mean 48.22, SD 14.48) years participated. Overall, 78 (57.7%) self-identified as blind and 57 (42.3%) as having low vision. In addition, 13 (9.6%) identified as having a combined vision and hearing loss and 3 (2.2%) as deafblind. The most common face coverings used were cloth (n=119, 88.1%) and surgical masks (n=74, 54.8%). Among the barriers raised, participants highlighted that face masks made it more difficult to locate people (n=86, 63.7%), communicate with others (n=101, 74.8%), and locate landmarks (n=82, 60.7%). Although the percentage of those who used a white cane before the pandemic did not substantially change, 6 (14.6%) of the 41 participants who were guide dog users prior to the pandemic reported no longer working with a guide dog at the time of the survey. Moreover, although guide dog users reported the highest level of confidence with independent travel before the pandemic, they indicated the lowest level of confidence a year after the pandemic began.

Conclusions

These results suggest that participants were less able to draw on nonvisual cues during independent travel and social interactions due to the use of a facemask, contributing to a reduction in perceived self-confidence and independence. Findings inform the development of evidence-based recommendations to address identified barriers.
A Telerehabilitation Program for Maintaining Functional Capacity in Patients With Chronic Lung Diseases During a Period of COVID-19 Social Isolation: Quasi-Experimental Retrospective Study
Authors: Miozzo Aline Paula , Camponogara Righi Natiele , Yumi Shizukuishi Maria Luiza , Marques Ferreira Aguilar Hérica , Florian Juliessa , da Costa Machado Scheila , Schardong Jociane , Della Méa Plentz Rodrigo
Published: October 2022

Background

Pulmonary diseases represent a great cause of disability and mortality in the world, and given the progression of these pathologies, pulmonary rehabilitation programs have proven to be effective for people with chronic respiratory diseases. During the COVID-19 pandemic, telerehabilitation has become an alternative for patients with such diseases.

Objective

The aim of this study was to compare the outcomes (ie, functional capacity and quality of life) of telerehabilitation to those of usual care among patients who previously participated in face-to-face pulmonary rehabilitation programs.

Methods

We conducted a quasi-experimental retrospective study from April 2020 to August 2021. A total of 32 patients with chronic lung diseases were included and divided into the control and intervention groups. The intervention group performed telerehabilitation synchronously twice per week and was supervised by a physical therapist during breathing, strengthening, and aerobic exercises. Changes in the degree of dyspnea and leg discomfort were assessed based on changes in Borg scale scores. The control group did not perform any activities during the period of social isolation. Functional capacity was assessed with the 6-minute walk test, and quality of life was assessed with the Medical Outcomes Study 36-item Short Form Health Survey.

Results

The telerehabilitation group’s mean 6-minute walk distance decreased by 39 m, while that of the control group decreased by 120 m. There was a difference of 81 m between the groups’ mean 6-minute walk distances (P=.02). In relation to the quality of life, telerehabilitation was shown to improve the following two domains: social functioning and mental health.

Conclusions

Telerehabilitation programs for patients with chronic lung diseases can ease the deleterious effects of disease progression, be used to maintain functional capacity, and improve aspects of quality of life.
This is test MS 12 Oct 2022 (Preprint)
Authors: Test Test
Published: October 2022

UNSTRUCTURED

This is test MS 12 Oct 2022
A Trainable Open-Source Machine Learning Accelerometer Activity Recognition Toolbox: Deep Learning Approach (Preprint)
Authors: Wieland Fluri , Nigg Claudio
Published: October 2022

BACKGROUND

The accuracy of movement determination software in current activity trackers is insufficient for scientific applications, which are also not open-source.

OBJECTIVE

To address this issue, we developed an accurate, trainable, and open-source smartphone-based activity-tracking toolbox that consists of an Android app (HumanActivityRecorder) and 2 different deep learning algorithms that can be adapted to new behaviors.

METHODS

We employed a semisupervised deep learning approach to identify the different classes of activity based on accelerometry and gyroscope data, using both our own data and open competition data.

RESULTS

Our approach is robust against variation in sampling rate and sensor dimensional input and achieved an accuracy of around 87% in classifying 6 different behaviors on both our own recorded data and the MotionSense data. However, if the dimension-adaptive neural architecture model is tested on our own data, the accuracy drops to 26%, which demonstrates the superiority of our algorithm, which performs at 63% on the MotionSense data used to train the dimension-adaptive neural architecture model.

CONCLUSIONS

HumanActivityRecorder is a versatile, retrainable, open-source, and accurate toolbox that is continually tested on new data. This enables researchers to adapt to the behavior being measured and achieve repeatability in scientific studies.
Extraction of Radiological Characteristics From Free-Text Imaging Reports Using Natural Language Processing Among Patients With Ischemic and Hemorrhagic Stroke: Algorithm Development and Validation (Preprint)
Authors: Hsu Enshuo , Bako Abdulaziz T , Potter Thomas , Pan Alan P , Britz Gavin W , Tannous Jonika , Vahidy Farhaan S
Published: October 2022

BACKGROUND

Neuroimaging is the gold-standard diagnostic modality for all patients suspected of stroke. However, the unstructured nature of imaging reports remains a major challenge to extracting useful information from electronic health records systems. Despite the increasing adoption of natural language processing (NLP) for radiology reports, information extraction for many stroke imaging features has not been systematically evaluated.

OBJECTIVE

In this study, we propose an NLP pipeline, which adopts the state-of-the-art ClinicalBERT model with domain-specific pretraining and task-oriented fine-tuning to extract 13 stroke features from head computed tomography imaging notes.

METHODS

We used the model to generate structured data sets with information on the presence or absence of common stroke features for 24,924 patients with strokes. We compared the survival characteristics of patients with and without features of severe stroke (eg, midline shift, perihematomal edema, or mass effect) using the Kaplan-Meier curve and log-rank tests.

RESULTS

Pretrained on 82,073 head computed tomography notes with 13.7 million words and fine-tuned on 200 annotated notes, our HeadCT_BERT model achieved an average area under receiver operating characteristic curve of 0.9831, F1-score of 0.8683, and accuracy of 97%. Among patients with acute ischemic stroke, admissions with any severe stroke feature in initial imaging notes were associated with a lower probability of survival (P<.001).

CONCLUSIONS

Our proposed NLP pipeline achieved high performance and has the potential to improve medical research and patient safety.
TYPE II DIABETES MELLITUS AND MANAGEMENT OF ISOLATED HYPERGLYCEMIA: A REVIEW
Authors: TELLO JUAN DIEGO CAYO , MORETTA DIANA ELIZABETH SÁNCHEZ , HERNÁNDEZ GABRIELA JENNIFER VARGAS , HERNÁNDEZ MEDINA LUIS SANTIAGO
Published: October 2022

Type II Diabetes mellitus (T2DM) is the most common of two types of Diabetes disease. T2DM is a metabolic disease characterized mainly by insulin resistance, reduction of insulin secretion, and hyperglycemia. T2DM is a major public health cause of concern not only by the increase in morbidity and mortality associated with patients with the disease, but also by the significant reduction in quality of life and productivity among the economically active population. Isolated hyperglycemia refers to patients with T2DM with normal fasting plasma glucose and no ketoacidosis. With the rise of T2DM and the presence of hidden symptoms, it is vital to determine a diagnostic sequence, blood-glucose control with sulfonylureas or insulin, and diet and exercise.
Correlation between Alcoholic beverage Consumption and Levels of Violence in the Neighborhoods of the city of Guajará-Mirim, Border with Bolivia
Authors: Cavalcante Fabio Robson Casara , Dias Bruna Darlen Pereira , Paraguassú-Chaves Carlos Alberto , Cavalcante Ana Maria Morais da Fonseca , Trindade Carla Dolezel , Filho Simão Aznar , Smith Ruy Drummont , Aznar Simão Dolezel , Almeida Fabrício Moraes de
Published: October 2022

Alcohol consumption is a prehistoric habit. There is archaeological evidence of its use in celebrations, rites or simple crowds of individuals. With the civilizing process, the consumption of alcoholic beverages was incorporated into acceptable social standards. Several scholars have concluded that alcohol is the substance most linked to behavioral changes caused by psychopharmacological effects that result in violence. Despite all the empirical evidence that reveals that alcohol is the most significant substance in the articulation with different forms of violence. The focus of this work is to know the scenario of alcohol consumption (beer) and violence in Guajará-Mirim. Thus, this paper aims to analyze the correlation between the consumption of alcoholic beverages in Guajará-Mirim, through the survey of the volume marketed by the existing distributors in the city, in relation to drug trafficking, theft, traffic accidents and physical aggression. The research method was inductive. The methodology was based on primary research to survey field data at Guajará-Mirim neighborhood level and secondary research to build the theoretical and methodological basis. The result shows a high positive correlation between the consumption of alcoholic beverages (beer) and some aspects of violence studied, which is consistent with other studies in this line of approach.
A Comparative Study in Different Topology to Design Push Pull Amplifier for Wide Band Application for Radio and Wireless Communications Systems
Authors: Tripathi Arunendra Nath , Tiwari Rajkumar , Tiwari Monika
Published: October 2022

Abstract: In this paper we present a comparative study of three topology to design push pull amplifier for wide band amplification, and also analysis among these and verify who is best for wide band application is use of radio & wireless communications, we examine topology at different parameters like frequency band width, transients’ analysis, power consumption’s, noise figure temperature stability etc and their uses.
From the Editors
Authors: Informal Logic
Published: October 2022

In the issue, Michael Gilbert first considers the history and development of his theory before Leo Groarke helpfully clarifies the differences and affinities between multi-modal and multimodal argumentation. Then, each of Gilbert’s modes is explored in a separate critical study, with David Godden attending to the logical mode, Linda Carroza to the emotional, Claudio Duran the visceral, and Christopher Tindale the kisceral. A final paper by Marko Novak applies the theory (particularly the kisceral mode) to the field of law. Together, these papers offer readers an opportunity to review the range of ideas associated with Gilbert’s model, and set the grounds for continuing research on this important theory.
Gilbert as Disrupter
Authors: Groarke Leo
Published: October 2022

Michael Gilbert’s multi-modal theory of argument challenges earlier accounts of arguing assumed in formal and informal logic. His account of emotional, visceral, and kisceral modes of arguing rejects the assumption that all arguments must be treated as instances of one “logical mode.” This paper compares his alternative modes to other modes proposed by those who have argued for visual, auditory, and other “multimodal” modes of arguing. I conclude that multi-modal and multimodal (without the hyphen) modes are complementary. Collectively, they represent an important attempt to radically expand the scope of informal logic and the argumentation that it studies.
On the Kisceral Mode of Argumentation
Authors: Tindale Christopher
Published: October 2022

Of the different modes that characterize Michael Gilbert’s multi-modal theory of argumentation, the kisceral is in many ways the most challenging to understand and employ. It appears to bypass the processes of reason that have dominated accounts in the Western tradition, diverting us toward the private worlds of hunches and gut reactions. This paper explores the nature of kisceral arguments, comparing them to the way intuition operates in William James’ examination of mystical experience. Having provided an account of kisceral arguments and their operation, the discussion turns to the even more challenging issue of how such arguments should be evaluated.
Reflections on the Physical or Visceral Mode of Argumentation in Michael Gilbert’s Theory of Multi-Modal Argumentation and its Relation to Gesture Studies and The Embodied Mind
Authors: Duran Claudio
Published: October 2022

In this paper I question the primacy of argumentation relying solely on logic by showing how the body and mind are deeply connected and as a result how communication and argumentation are a product of this mind/body connection. In particular, I explore the physicality of argumentation through the research and writings on gestures and the embodied mind. Michael Gilbert’s theory of multi-modal argumentation provides the general approach for this elaboration.
Analysis of The Safety and Efficacy of Different Types of Anesthesiological Support During Aesthetic Interventions For The Breast Glands In Ukraine
Authors: Kuchyn Iurii , Sazhyn Dmytro , Patlazhan Gennadiy
Published: October 2022

In the prevailing era, mammoplasty is prevalent among women. Undeniable benefits of the method are the preservation of most anatomical structures and skin, and also better psychological status of patients after intervention. Hence, the present study intends to examine the features of aesthetic and reduction surgical interventions on the mammary glands in Ukraine. Materials and methods. The study was conducted by analyzing the inpatient ambulatory cards of 320 patients. Anesthesia was provided by propofol (n=130), sevoflurane (n=140) and combined use of sevoflurane and nalbuphine (n=50). The results of the study. It was found that usage of combined inhalation analgesia of sevoflurane with opioids was characterized by 41.9% less recovery time. It was found that 8 hours after surgery, the individual assessment of pain was lower in the group of combined analgesia with opioids relative to intravenous anesthesia with propofol (87.5%, p<0.05) and inhalation anesthesia with sevoflurane (71, 3%, p<0.05). After 24 hours all patients reported about pain below 1.0 point, however, in groups where sevoflurane and nalbuphine were used, the level of pain self-esteem was 2.61 and 3 times lower than after intravenous propofol. It was found that within 1 hour after surgery, the average cognitive score on the Montreal scale decreased in the group of intravenous propofol by 5.0% (p<0.05) and by 1.7% under inhalation anesthesia with sevoflurane. Under combined anesthesia the cognitive score remained at 12.0 points. The frequency of postoperative nausea was the highest level in the group of inhalation anesthesia - 16.7%. The addition of nalbuphine to sevoflurane significantly reduced the risk of postoperative nausea (? 2=7.250; p=0.007). Conclusions. Combined anesthesia with opioids is a highly effective anesthetic choice for aesthetic and reconstructive interventions on the mammary glands.
The procedure for legalizing foreign public documents after the Apostille Convention accession: A statutory approach study
Authors: Crisindiana Maretha , Trihastuti Nanik
Published: October 2022

This research was based on the national efforts to simplify the procedure for the legalization of foreign public documents to improve the investment climate. This research focuses on the implementation of the legalization of foreign public documents after the accession of the Apostille Convention in Indonesia. The main basis for examination was Presidential Regulation No. 2 of 2021 on the Accession of the Convention of Abolishing the Requirement of Legalization for Foreign Public Documents, also known as the Apostille Convention. The method used is a normative juridical research method. This research emphasizes library research by using secondary data sources such as statutory provisions, legal theory, and scientific works (Suteki & Taufani, 2020). The statutory approach is carried out by analyzing the statutory provisions related to the legal issues being studied (Marzuki, 2016). Furthermore, an analysis of legal materials is carried out using qualitative analysis described in sentences without mathematical calculations or statistics as an analytical tool. The results showed that the implementation of the Apostille Convention does not necessarily render the current legalization of public documents invalid, but rather replaces it with a simpler procedure, namely the issuance of an apostille certificate, which functions as a statement of the validity of the document. The conclusion highlighted the need for ratifying the Apostille Convention comes into force, especially in ASEAN member countries to enhance the foreign direct investment in this association.
Protocol for expediting drug targets search in S . Typhi through subtractive genomics and the identification of lead-based novel small molecules
Authors: Hassan Syed Shah , Salman Muhammad , Morel Carlos M. , Afzal Muneeba , sohail saman , Camps Ihosvany , Khan Yasmin , Basharat Zarrin , Karim Asad , Aurongzeb Muhammad , Irfan Muhammad
Published: October 2022

Typhoid fever is transmitted by ingestion of polluted water,
contaminated food, and stool of typhoid-infected individuals, mostly in
developing countries with poor hygienic environments. To find novel
therapeutic targets and inhibitors, the complete genomes of eight
Salmonella Typhi strains were primarily subjected to the EDGAR
tool to predict the core genome (n=3207). Human non-homology (n=2450)
was followed by essential genes identification (n=37). The STRING
database predicted maximum protein-protein interactions, followed by
cellular localization. The virulent/immunogenic ability of predicted
genes were checked to differentiate drug and vaccine targets.
Furthermore, the 3D models of the identified putative proteins encoded
by the respective genes were constructed and subjected to druggability
analyses where only “highly druggable” proteins were selected for
molecular docking and simulation analyses. The putative targets include
ATP-dependent CLP protease proteolytic subunit, Imidazole glycerol
phosphate synthase hisH, 7,8-dihydropteroate synthase folP and
2,3-bisphosphoglycerate-independent phosphoglycerate mutase gpmI. A ZINC
drug-like library (n=12000) was screened against each identified targets
and top hits were selected based on H-bonds, RMSD and energy scores.
Finally, the ADMET properties for novel inhibitors ZINC19340748,
ZINC09319798, ZINC00494142, ZINC32918650 were optimized followed by
binding free energy (MM/PBSA) calculation for ligand-receptor complexes.
The findings of this work are expected to aid in expediting the
identification of novel protein targets and inhibitors in combating
typhoid Salmonellosis, in addition to the already existing therapies.
Plant diversity and soil legacy independently affect the plant metabolome and induced responses following herbivory
Authors: Ristok Christian , Eisenhauer Nico , Weinhold Alexander , Dam Nicole van
Published: October 2022

Plant and soil biodiversity can have significant effects on herbivore
resistance mediated by plant metabolites. Here, we disentangled the
independent effects of plant diversity and soil legacy on constitutive
and herbivore-induced plant metabolomes of three plant species in two
complementary microcosm experiments. First, we grew plants in sterile
soil with three different plant diversity levels. Second, single plant
species were grown on soil with different plant diversity-induced soil
legacies. We infested a subset of all plants with Spodoptera exigua
larvae, a generalist leaf-chewing herbivore, and assessed foliar and
root metabolomes. Neither plant diversity nor soil legacy had
significant effects on overall foliar, root, or herbivore-induced
metabolome composition. Herbivore-induced metabolomes, however, differed
from those of control plants. We also detected 139 significantly
regulated metabolites by comparing plants grown in monocultures with
conspecifics growing in plant or soil legacy mixtures. Moreover,
plant-plant and plant-soil interactions regulated 141 metabolites in
herbivore-induced plants. Taken together, plant diversity and soil
legacy independently alter the concentration and induction of plant
metabolites, thus affecting the plant’s defensive capability. This is a
first step towards disentangling plant and soil biodiversity effects on
herbivore resistance, thereby improving our understanding of the
mechanisms that govern ecosystem functioning.
Early childhood education instructors’ teaching practice and perceptions of distance learning
Authors:   The Korea Associantion For Early Childhood Education Administration, Choi Il-Sun , Lee Seong-Yeon , Lee Jin-Wha
Published: October 2022

The purpose of this study was to investigate the teaching practice and perceptions of distance learning among early childhood education instructors who have implemented online-based distance learning due to COVID-19. For this purpose, 139 instructors who taught early childhood education courses participated an online survey. The collected data were analyzed by frequency and percentage.
The results of this study are as follows. First, about 76% of early childhood education instructors had no experience of distance learning before COVID-19, and the training experience of distance learning was high at about 82%. The early childhood education instructors utilized the combination of real-time interactive classes and video content classes the most, and the frequency of using materials developed by them was high. Second, the early childhood education instructors recognized that the combination of real-time interactive classes and video content classes was the most effective and perceived the effect of non-face-to-face classes and face-to-face classes to be different, and a main reason of the difference was in the interaction between instructors and learners. As the advantages of distance learning, more than 90% of the instructors chose no time and space constraints and convenience due to non-contact. In order to increase the effectiveness of distance learning, they recognized that various improvements were needed, and among them, strengthening learners’ participation was the most necessary. More than 70% of the instructors answered that they are willing to continue at least some of the distance learning after COVID-19. For high-quality distance learning, they perceived that the instructors should develop interaction skills with learners and competencies related to distance learning, while universities should support instructors’ competencies for distance learning and make technical improvements. These results suggest the need to prepare a support system that reinforce instructor’s competencies for distance learning.
The Parallel Multiple Mediating Effect of Child Care Teacher's Teacher Efficacy in the Relationship Between Self-Care and Burnout
Authors:   The Korea Associantion For Early Childhood Education Administration, Lim Joung-Won , Cha Mi-Suk
Published: October 2022

The purpose of this study was to analyze the parallel multiple mediating effect of child care teacher’s teacher efficacy in the relationship between self-care and burnout. The survey was conducted on 276 teachers of 3 to 5 year classroom from daycare centers in Seoul and Gyeonggi-do. Participants responded to questionnaires that measured burnout, self-care, and teacher efficacy. The collected data was analyzed by descriptive statistics, correlation analysis using SPSS 26.0. Furthermore, the parallel multiple mediating effect was analyzed using the PROCESS Macro for SPSS version 3.5 (Model 4) and the statistical significance of the meditating effect was examined by bootstrapping. The results were as follow. First, self-care, burnout, and teacher efficacy of child care teacher were found to be correlated. Second, only classroom management in the subfactors of teacher efficacy was found to have the partial mediating role in the relationship between self-care and burnout. The results of this study emphasize the importance of self-care and teacher efficacy for child care teacher’s burnout. These findings can serve resources to develop programs for child care teacher’s burnout.
The mediated effect of teacher efficacy on the relationship between adult attachment and teacher-child interaction
Authors:   The Korea Associantion For Early Childhood Education Administration, Sohn Soo-Min
Published: October 2022

The purpose of this study is to investigate the mediating effect of teacher efficacy on the adult attachment and the interaction relationship between teachers and children. To achieve the research goal, this study analyzes data collected from 201 teachers who work in the 3 to 5 year old classes of the kindergartens and daycare centers located in Seoul and Gyeonggi-do, South Korea from April. 18th to June 1st, 2022. For data analysis, IBM/SPSS 26.0 and Process Macro programs are used to check the descriptive statistics and internal consistency and conduct correlation analysis and mediating regression analysis. The analyzed data show the following results. First, teachers' adult attachment has negative correlation with teacher efficacy, but it has positive correlation with teacher-child interaction. Second, the partial mediating effect of teacher efficacy is found in the effect of adult attachment on the interaction between teachers and children. This research outcomes imply that teacher efficacy is the influential factor that enhances high-quality teacher-child interactions and diminishes the negative effect of adult attachment. The implications and suggestions for follow-up studies are provided based on the research outcomes.
Wpływ możliwych zmian struktury i poziomu intensywności produkcji na produkcyjność roślin i siłę oddziaływań środowiskowych w perspektywie 2030 roku
Authors: Kolpiński Jerzy , Smagacz Janusz , Stalenga Jarosław
Published: October 2022

W pracy dokonano oceny zmian w strukturze produkcji roślinnej i poziomu intensywności nawożenia mineralnego NPK oraz bilansu azotu brutto w latach 2012-2020 i w perspektywie roku 2030. W opracowaniu przyjęto szereg założeń prognostycznych uwzględniających możliwość realizacji celów koncepcji EZŁ w uwarunkowaniach przyrodniczo-produkcyjnych polskiego rolnictwa. Z analizy wynika, że w perspektywie 2030 roku należy oczekiwać obniżenia intensywności nawożenia i całkowitej produkcji roślinnej, przy wzroście powierzchni upraw ekologicznych, z jednoczesną poprawą efektywności wykorzystania składników nawozowych, co powinno prowadzić do zmniejszenia presji ze strony biogenów (azotu) na środowisko.
Modular teaching of russian to chinese students
Authors: Wang Yameng
Published: October 2022

In this article, we will examine the characteristics of a model of teaching Chinese students, which is built on two key components. These are the Confucian attitudes of a collectivist society, which contribute to such characteristic traits as respect for the teacher, hierarchical social structure, and the importance of saving face. Second is the peculiarity of the Chinese educational system, which is focused on taking tests and memorizing ready-made answers. In this situation, it is necessary to consider the specifics of working with Chinese students. This article analyzes the learning strategies of Chinese students, as well as historical, political, economic and cultural factors in their formation. English teachers need to pay more attention to the use of communicative methods in their work in order to intensify the learning.
Features of business planning of innovation activities in scientific and educational organizations
Authors: Mukhamedshin Irik Sabirzhanovitch , Pyataeva Olga Alexeevna , Korneev Pavel Sergeevitch , Borisova Maria Sergeevna , Evdokimova Maya Igorevna
Published: October 2022

The purpose of the article is to summarize existing approaches to business planning, to define the structure of the business plan, to emphasize the difference between business planning of scientific organizations in higher education institutions and the corresponding process in commercial organizations, and Make recommendations on the organization and implementation of the planning procedure for the Russian education and scientific development sector. The article presents the main stages of the innovation process, the specificity of the innovation process, and its two-stage nature (where the first stage is completed with the creation of «novation» and the second - «innovation»). The authors present a business planning process and emphasize the peculiarities of its development in institutions scientific and educational organizations. Based on such analysis, the authors make recommendations for business plan developing for such types of organizations.
Psychological conditions for the development of the communicative culture of students
Authors: Goverdovskaya Elena V. , Dokhoyan Anna M. , Tatarintseva Ekaterina A.
Published: October 2022

The article examines the issues of the development of professional communicative culture among pedagogical university students. The importance of introducing active teaching methods in the learning process is stressed. The goal of the study is to describe and analyze the experience in the development of students’ communicative culture relevant for the system of higher pedagogical education. The contradictions between the growing demands on professional mastery and business communication skills and the insufficient qualification of teachers constitute the basis of the problem of the study: what are the psychological conditions for the development of students’ communicative culture in the process of professional training at university? The authors conduct an empirical study using qualitative and quantitative data analysis methods and emphasize the role of elective courses, programs, and specialized disciplines as a psychological condition for the development of students’ communicative culture.
Conceptual approaches to the interaction of labor market entities and educational institutions in the Russian Federation within the ecosystem based on neural network mechanisms
Authors: Alenina Elena Eduardovna , Ziulina Vera Vitalievna , Alenin Ilya Aleksandrovich , Bolotnikov Sergey Vladimirovich , Redin Dmitry Vladimirovich , Borodacheva Lyubov Viktorovna
Published: October 2022

The purpose of the study: to develop and describe, the process of functioning of a neural network system of expert justification of management decisions in the field of preparation of educational programs for promising activities using graphical modeling methods. Results: conceptual approaches to ensuring the interaction of labor market entities and educational organizations of the Russian Federation within the information and communication ecosystem based on neural network mechanisms described in the BPMN 2.0 notation have been proposed. The main subjects of the system have been characterized through the "pool" and "swimline" tools, their interaction through the "flow", "messages flows" tools, the main operations displayed through private processes data mining, IDSS, communication driven and document driven interaction. The scientific novelty of the study: the concept of strategic interaction between the subjects of the labor market and educational institutions of the Russian Federation based on automation of communication and the use of neural network mechanisms has been proposed.
The impact of innovative stem education technologies on the quality of learning of educational material
Authors: Grunina Yulia Alexandrovna , Malenkova Aksinia Avenirovna , Gasanbekov Sergey Kurbanovich , Maslennikova Elena Gennadievna , Solovyanenko Nina Ivanovna
Published: October 2022

The peculiarity of professionally oriented training of applicants for higher education based on STEM technologies is the need to take into account interdisciplinary connections as a manifestation of integrative processes of penetration of fundamental disciplines (physics), natural and mathematical knowledge into the cycle of subjects of professionally oriented training of students, which is provided not only by basic physical, mathematical and technical competencies of the 21st century but also by key methodological knowledge taking into account applied aspects. These connections play a leading role in improving the quality of professionally oriented training of future specialists. The purpose of the article is to determine the impact of innovative technologies of STEM education on the quality of learning of educational material through a physical experiment. The article experimentally substantiates the effectiveness of using the STEM approach when performing laboratory work to form the studied physical concepts in comparison with traditional teaching methods. It has been shown that the use of the STEM approach improves the level of assimilation of concepts in comparison with traditional teaching methods. In the case of using the STEM approach, the number of students with a high level of assimilation of concepts increases significantly, while the number of students with a low level decreases, which proves the effectiveness of using the STEM approach for the formation of high-level knowledge and skills. The article highlights the features of the formation of the STEM component in teaching in the innovative educational and scientific environment of the technical university, as well as the features of the teaching methodology taking into account STEM-learning technologies. It has been concluded that the use of the STEM approach significantly improves the level of assimilation of physical concepts in comparison with traditional teaching methods.
The Influence of Professional Commitment and Rationalization-Discrediting Interventions on Unethical Audit Decisions
Authors: Lowe D. Jordan , Reckers Philip M. J. , Sauciuc Ashley K.
Published: October 2022

Individuals often engage in a rationalization process to self-justify questionable conduct. However, as “gatekeepers” to the market, it is vitally important for professional auditors to avoid such practices. Recognizing that some individuals may be more prone to rationalize than others, we first identify an important subset of professional auditors that we expect is more susceptible to rationalizing unethical behavior: those with low professional commitment. We then examine whether rationalization-discrediting interventions can mitigate such behavior among this auditor subset. Specifically, we developed interventions geared toward discrediting some of the most commonly-used rationalizations found in practice in order to promote a more ethical mindset and reduce unethical behavior. Using professional auditor participants, our results confirm that auditors with low (high) professional commitment are more (less) likely to accede to unethical requests from superiors. Further, among those with low professional commitment, our rationalization-discrediting interventions were effective in reducing unethical intentions.