bluuebunny/crossref_metadata_2025 huggingface dataset:
Behaviour typologies in ukrainian children and adolescents at the implementation of quarantine measures during COVID-19 pandemic
Authors:   State Institution ", Yelizarova O.T. ,   O.M. Marzіeiev Institute for Public Health of the NAMSU", Polka N.S. ,   State Institution "O.M. Marzіeiev Institute for Public Health of the NAMSU", Hozak S.V. ,   State Institution "O.M. Marzіeiev Institute for Public Health of the NAMSU", Parats A.M. ,   State Institution "O.M. Marzіeiev Institute for Public Health of the NAMSU", Lynchak O.V. ,   State Institution "O.M. Marzіeiev Institute for Public Health of the NAMSU", Stankevych T.V. ,   State Institution "O.M. Marzіeiev Institute for Public Health of the NAMSU"
Published: December 2020

For the effective and safe implementation of quarantine measures for the prevention of infectious diseases, it is necessary to a create the conditions for the maintenance of physical and mental health of the population, especially of the children and adolescents, the most vulnerable part of it. The monitoring of quarantine conditions, as well as a lifestyle of children with the identification of possible negative factors affecting the health of schoolchildren, is a prerequisite of it. Objective: We assessed the living conditions of school-age children during the COVID-19 pandemic lockdown. Materials and methods: We analyzed the results of the online survey of the parents of 920 children and adolescents from all regions of Ukraine (497 boys and 432 girls). All respondents signed informed consent. Data were collected from April 17 to June 5, 2020. We applied STATISTICA 8.0 for statistical analysis. Results: Only (59.4±1.7)% of urban and (33.1±4.3)% of rural families with school-age children adhered to quarantine rules (p<0.001). The probability of the deviation from the quarantine rules is 1.7 times higher in rural regions than in urban ones (RR=1.65; CI 1.42-1.92; p<0.001), and 1.4 times higher in the parents with secondary education than in the parents with higher education (RR = 1.41; CI 1.22-1.62; p<0.001). (25.0±1.4)% of school-age children were determined not to leave their homes during the lockdown. About 60% of school-age children went for a walk 1-7 times a week (10-60 min/day). Proportion of children and adolescents with walk duration of more than 60 min/day with a frequency of 5-7 times a week during quarantine made up only (10.3±1.0)%, while before quarantine - 48.5%. Conclusions: Revealed trends demonstrate a need for the development and promotion of the measures for the rise of the population awareness on the importance of compliance with quarantine rules, taking into account demographic and social characteristics. It is necessary to develop ways to achieve optimal duration of outdoor walk for children.
Hyperhomocysteinemia in children and forest fires in the Chоrnobyl exclusion zone
Authors:   Ecology and Health Coordination and Analytical Centre, Ivankiv, Bandazhevsky Yu.I. , Dubova N.F. ,   P. L. Shupyk National Medical Academy for Post-Graduate Education, Kyiv
Published: December 2020

Objective: We determined a role of folate metabolism genotypes in the occurrence of hyperhomocysteinemia in children after a forest fire in the Chоrnobyl exclusion zone (ChEZ). Material and methods: In the study, we applied immunochemical, Real-time PCR, mathematical and statistical methods. Results: A survey of 84 adolescents from the Poliske district, Kiev region revealed changes in their metabolic processes in the form of increased homocysteine production in connection with a forest fire in the ChEZ which was recorded during April 26-29, 2015. A comparative analysis of the specific gravity of the folate cycle genotypes in the subgroups of the children with hyperhomocysteinemia before and after a forest fire showed that an endogenous factor in the form of a genetic apparatus, controling synthesis of folate cycle enzymes, was not involved in this phenomenon. Сonclusions: Forest and peat fires in the Chernobyl exclusion zone are one of the main causes for the elevation in blood homocysteine levels in children from the adjacent districts, regardless of the state of folate metabolism genetic system. Monitoring of the blood homocysteine levels in children and adults living under conditions of the exposure to wood combustion gases, containing radioactive elements, is a key component of the programmer for the prevention of cancer and cardiovascular diseases.
DENYS MYKOLAIOVYCH KALIUZHNYI IS AN EXCELLENT SCIENTIST-HYGIENIST OF THE XX CENTURY (In commemoration of 120th Anniversary)
Authors:   STATE INSTITUTION “O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH” NAMSU, Serdiuk A.M. , Savina R.V. ,   STATE INSTITUTION “O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH” NAMSU
Published: December 2020

This work is dedicated in commemoration of 120th anniversary of Kaliuzhnyi D. M. – an excellent scientist-hygienist of the twentieth century, director of the State Institution "IPH NAMNU" 1956-1970 and covers the main stages of his life and research.
RESULTS OF OBSERVATIONS ON THE INDICATORS OF THE DNIPRO WATER, WHICH INTENSIFY ITS "BLOOMING", AND RECOMMENDATIONS OR PREVENTIVE MEASURES
Authors:   STATE INSTITUTION “O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH” NAMSU, Zorina O.V. , Prokopov V.O. ,   STATE INSTITUTION “O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH” NAMSU, Antomonov M.Y. ,   STATE INSTITUTION “O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH” NAMSU
Published: December 2020

Objective. Analysis of the results of systematic observations of the indicators that characterize the "blooming" of the water of the Dnieper River in space-time aspect, and providing recommendations for its prevention. Materials and methods. To assess the water quality of the Dnieper River, an array of data from the State Agency of Water Resources "Dnieper Basin Water Resources Management" (2015–2017, 906 samples), the State Water Cadastre (2016), "UNHC Ministry of Health" on the state of water in Ukraine (1992–1994), “National Report on Drinking Water Quality and the State of Drinking Water Supply in Ukraine” (2005–2016), Lithuanian Waste Management Regulation (2006), Council Directive 91/271/ЄEC. Methods were used for data processing: analytical, statistical, correlation, mathematical modeling. Results and conclusions. A high content of phosphates and organic substances in the water of the Dnipro river in the spatial-and-temporal section is demonstrated, which indicates a natural and anthropogenic contamination and will lead to the potential problems with the contamination of tap drinking water made of the Dnipro water. It is proved that one of the priority tasks today should be to reduce the content of organic matter, phosphorus and nitrogen in surface waters, which can be achieved by establishing coastal strips and provided by law, as well as the use of modern technologies for industrial and domestic wastewater treatment, this requires regulation. Further harmonization of Ukraine’s water legislation with European legislation will help prevent water-related morbidity.
ON THE INFLUENCE OF THE COMBINATION OF THE COMBINED ACTION OF ELECTROMAGNETIC RADIATION AND NOISE ON THE STATE OF MORPHOLOGICAL ELEMENTS OF BLOOD
Authors:   STATE INSTITUTION “O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH” NAMSU, Tomashevskaya L.A. , Kravchun T.E. ,   STATE INSTITUTION “O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH” NAMSU, Nikitina N.G. ,   STATE INSTITUTION “O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH” NAMSU, Didyk N.V. ,   STATE INSTITUTION “O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH” NAMSU, Chubuk T.A. ,   STATE INSTITUTION “O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH” NAMSU
Published: December 2020

The aim. Study of hematological parameters under conditions of combined action on the body of experimental animals. Subject and methods. The effect of electromagnetic radiation on the state of morphological elements of the blood. Hematological, statistical methods. Results. A two-month experiment was performed on white rats exposed to EMR at the levels of 100, 500 and 2500 μW/cm2 and acoustic noise of 85 dBA. The structure of the leukogram changed due to changes in the absolute number of leukocytes (increase), lymphocytes (decrease), monocytes (decrease) and granulocytes (decrease). Since lymphocytes belong to immunocompetent cells and assessing the nature of their changes during 60 days of the experiment, we can assume that there is an increase in regenerative processes in the lymphocyte population and activation of the immune system by damaging factor, followed by gradual depletion of compensatory mechanisms and suppression of suppressor mechanisms. Decreased hemoglobin levels and a decrease in the average concentration of hemoglobin in erythrocytes may indicate low blood O2 saturation and the development of anemia, with the subsequent development of dysfunction of all organs and systems of the body. Conclusions. The nature of changes in hematological parameters during the experiment may be a manifestation of mobilization of functional systems and the formation of adaptive responses aimed at maintaining the stability of homeostasis in the studied factors with possible prolongation of their further disruption, suppression of regenerative processes in the blood and depletion of compensators, or the development of various reparation reactions that provide protective - restorative functional systems to maintain the dynamic balance of the organism with the environment.
COMMUNICATION STRATEGIES FOR INFORMATION ABOUT RADON RISKS
Authors:   STATE INSTITUTION “O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH” NAMSU, Aksenov N. , Fryziuk M. ,   STATE INSTITUTION “O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH” NAMSU, Pavlenko T. ,   STATE INSTITUTION “O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH” NAMSU, Fedorenko O. ,   STATE INSTITUTION “O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH” NAMSU, Mykhailenko O. ,   STATE INSTITUTION “O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH” NAMSU
Published: December 2020

The article analyzes and determines the most effective directions of communication strategies and specific approaches to the choice of ways to inform the population about radon risks. Communicating with the public about radon risks is an integral part of the national radon action plan, and radon risk communication is a specific requirement of the IAEA's Basic Safety Standards. An effective risk communication strategy provides for a multi-stakeholder information flow involving stakeholders (all stakeholders) - representatives of communities living at risk, regulators, experts, radiation safety inspectors, and should focus on informing different audiences and recommending appropriate protective measures. It is also very important to take into account both the demographic and socio-economic context of the population and the use of quantitative and qualitative approaches to information. National and regional departments, local health authorities and non-profit organizations should work together to share knowledge, experience, resources and ideas that will stimulate radon measurements and protective actions. An effective component of a radon risk communication campaign is to identify target audiences that need to be informed and persuaded to take the necessary protection measures, and raising public awareness of the need to reduce radon levels in homes should be a key communication strategy. In the process of risk communication, an important aspect is the approach to the choice of ways of informing and developing the content of information messages. The effectiveness of communications will increase significantly if you join existing other information campaigns, such as energy efficiency, smoking control, labor protection and the like. Communication should be an ongoing process and should be carried out at all stages of the implementation of the radon action plan.
ANALYSIS OF DETERMINANTS OF PRIMARY SCHOOL CHILDREN’S PHYSICAL ACTIVITY INCLUDING INTERNATIONAL EXPERIENCE
Authors:   STATE INSTITUTION “O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH” NAMSU, Hozak S.V. , Yelizarova O.T. ,   STATE INSTITUTION “O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH” NAMSU, Stankevich T.V. ,   STATE INSTITUTION “O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH” NAMSU, Parats A.M. ,   STATE INSTITUTION “O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH” NAMSU
Published: December 2020

The aim of research was to fulfill an analytical review of original scientific publications including foreign experience that determine the factors of influence on physical activity level of children of primary school age. Methods. Structural and logical analysis method, semantic bibliography method. Results. It was found that only an integrated approach can significantly affect the increase on the level of children`s physical activity. Both modifying public policy and the environment for children with intervention through the involvement of the media space, parents and collaboration of specialists from different related areas can really contribute to the active lifestyle of primary school children.
Kriteria Desain Dinding Penahan Pada Tanah Campuran
Authors: Apriani Dyah Wahyu , Hadid Muhammad
Published: December 2020

Retaining wall is one of the reinforcing techniques used to control soil movement. Reinforcement with retaining walls is relatively expensive so an efficient design is needed. Unfortunately, the guidelines for planning a retaining wall are limited. Analysis of design criteria was carried out on silt clay soil taken in the area of the Karang Joang Kalimantan Institute of Technology (ITK) area based on the dimension guide given by Hardiyatmo (2010) and Nakazawa, et al (1980) for safe slope height based on the type of retaining wall. The minimum criteria for cantilever type retaining walls with a slope height of 2-3 meters is the width of the TOE (A) = B / 3 meters, the base width retaining wall (B) = minimum of 0.7 H meters, the width of the upper wall (C) = 0.2 meters and wall thickness (D) = H / 10-H / 12 meters, while for slopes with a height of 4- 5 meters the safe dimension range is TOE (A) width = A / 3, slope width (B) is designed to be a minimum of 0.9 H meters, width of the wall (C) = minimum 0.2 meters and wall thickness (D) = H / 10-H / 12 meters. Gravity retaining wall has design criteria for slopes as high as 2-3 meters of A = D / 2-D meters, B is taken to a minimum of 0.7 H meters, a minimum C value of 0.3 m and D of H / 8 - H / 6 meters for slopes with a height of 2-3 meters, meanwhile for slopes with a height of 4-5 meters, B to a minimum of 0.9 H meters, with a value of A = D / 2-D meters, the C value is designed to be a minimum of 0.3 meters and D = H / 8 - H / 6 meters.
PEMODELAN PENGARUH PEMOMPAAN SUMUR PRODUKSI PADA AKIFER DENGAN MUKA AIR TANAH MIRING
Authors: Ramli Muhammad , Idris Muhram Sula , Wihdah Wihdah , Almuqarram Aswad , Khaerunnisa Hamdana
Published: December 2020

The main issue in the utilization of ground water is always related to the decrease in water table or piezometric level. The decreasing of groundwater level is often accompanied by number of environmental impacts such as; subsidence, sea water intrusion, or reduced water from residents' wells and surface water bodies. Therefore, an experimental and numerical study was carried out to learn phenomena of cone depression resulted by groundwater production well. The experimental study of physical modeling used the S12-MKII Hydrology Study System equipment, and numerical modeling used Groundwater Modeling Software - Modflow. The modeling results were verified by analytical estimation. The results indicated that the groundwater withdrawn obtained with physical model and numerical simulation is bigger than estimated by analytical equation, particularly in estimating groundwater divide to a well.
STUDI EKSPERIMENTAL KERUNTUHAN RANGKA KUDA-KUDA BAJA RINGAN PADA ATAP RUMAH DAN SEKOLAH
Authors: Utomo Adityo Budi , Satyarno Iman , Muslikh Muslikh
Published: December 2020

Increasingly expensive price of quality woods and difficulties of workmanship, it makes people switch from wood to lightweight steel as a roof truss. The use of lightweight steel as truss becomes popular because of the fast workmanship dan durability of the material. Many cases show that lightweight steel truss at school and house collapsed and caused a fatality. This lightweight steel truss study was carried out on a full scale with a span of 6 m and a slope of 300, while the loading test pattern at the placement points of battens was like truss in the community. The goals of this study to measure and observe several parameters including weight, maximum capacity, stiffness, ductility, price, length of work, and failure pattern. From testing, the result shows that lightweight steel truss has dead weight, maximum capacity, stiffness value, ductility value, price, working time, and failure pattern respectively of 21,3 kg,734 kg, 91,18 kg/mm, 2,97, Rp 1.740.000, 2 days, and failure pattern is buckling on the diagonal top chord. The result of this research indicates that lightweight steel truss can be used in the community with the limitation of using metal roof coverings instead of concrete or ceramic and the distance between the truss max 1,2 m.
Millî Mücadele Yıllarında Anadolu’da Yeni Gün Gazetesinde Cumhuriyet, Cihan İnkılabı ve Millî Komünizm Meseleleri
Authors: Canpolat Mukaddes
Published: December 2020

Anadolu’da Yeni Gün gazetesi Milli Mücadele yıllarında Hakimiyet-i Milliye gazetesinden sonra TBMM’nin sözcülüğünü yapmış Ankara’daki ikinci gazetedir. Gazete, Yeni Gün adıyla Yunus Nadi (Abalıoğlu) Bey yönetiminde 2 Eylül 1918’de İstanbul’da yayın hayatına başlamıştır. 10 Ağustos 1920’den itibaren Ankara’da Anadolu’da Yeni Gün adıyla yayını sürdürmüş, 8 Mayıs 1924’ten itibaren ise İstanbul’da Cumhuriyet adıyla yayımlanmıştır. Anadolu’da Yeni Gün gazetesi Ankara’daki yayın hayatı boyunca bazı ana temalar üzerinde odaklanmıştır. Bu temaların başında halk idaresi, halk hükümeti ve Cumhuriyet kavramları gelmektedir. Gazete bu temaları destekleyen bir yayın çizgisi izlemiştir. Bir diğer temel tema Milli Mücadele yıllarında BMM ve Sovyet Rusya arasında yakınlaşan ilişkiler nedeniyle Bolşeviklik, milli komünizm olmuş ve gelecekte Türk devletinin benimseyebileceği anlayış olarak “Şark Menşevikliği” kavramı önerilmiştir. Şark Meselesi, Anadolu’da Yeni Gün’de öne çıkan bir diğer temadır.
Habilidades de comunicação interpessoal entre casais: Contribuições da terapia cognitivo comportamental
Authors: Pantoja Josicleia da Silva , Martins Maria das Graças Teles
Published: December 2020

Casais, vez por outra, vivem conflitos conjugais cotidianos, porém, a grande questão está na forma como esses conflitos são resolvidos por eles. Entende-se que a comunicação habilidosa entre casais poderá proporcionar satisfação conjugal e melhor resolução nos problemas que surgem. O objetivo deste estudo foi investigar as habilidades sociais de comunicação na relação conjugal e as contribuições da Terapia Cognitivo Comportamental – TCC. Buscou-se ainda, identificar as formas positivas e deficitárias de comunicação no relacionamento conjugal. A metodologia utilizada foi a pesquisa de campo de caráter quanti-qualitativo e exploratório. Os instrumentos aplicados foram o Inventário de Habilidades Sociais Conjugais – IHSC, em 20 (vinte) pessoas casadas formalmente ou não, integrantes de uma instituição religiosa da cidade de Macapá-AP. Os resultados indicam que as mulheres apresentam maior déficit em autocontrole proativo e os homens maior dificuldade em conversação assertiva. As considerações finais refletem que: As habilidades sociais, treino de comunicação, assertividade e resolução de problemas são componentes técnicos utilizados pela TCC que podem ajudar na forma de comunicação de casais, para que os mesmos possam adquirir estratégias que amenizem seus conflitos. O terapeuta cognitivo comportamental buscará favorecer ao casal, por meio de técnicas e estratégias cognitivo-comportamentais, as habilidades necessárias para uma comunicação positiva. Poderá proporcionar acordos entre os pares para mudança cognitiva, afetiva e comportamental pois, a intervenção na TCC objetiva o estabelecimento do equilíbrio na relação, reduzindo conflitos e distorções cognitivas que permeiam as relações do casal.
La evolución histórica de la Salud Pública
Authors: Neto Daniel Carlos , Dendasck Carla , Oliveira Euzébio de
Published: December 2020

Se encuentra en los primeros registros históricos, la búsqueda constante del hombre para la búsqueda de la cura de sus enfermedades. Uno de los primeros registros que uno tiene con respecto al ejercicio de la medicina a través de la Biblia misma, donde además menciona la búsqueda de individuos para curar sus enfermedades. Conocer la evolución histórica de la Salud, especialmente la salud pública, es fundamental para entender los fenómenos que forman parte del marco contemporáneo, buscando así, a través de este reconocimiento extraer lecciones que permitan estrategias administrativas y/o resolutivas para lo que se considera la “crisis del sistema de salud”.
The Benefits of Implementing Supervisory Board in the Healthcare System of Kazakhstan
Authors:   Medical Expert of the Medical Center Hospital of President’s Affairs Administration of Republic of Kazakhstan, Independent medical accredited expert of the Non-governmental Organization “Association of Independent Medical Experts of Nur-Sultan”, Saiynov Muratbek , Dyussengalieva Gulbarshyn ,   Pediatrician of the City polyclinic No.13
Published: December 2020

In order to increase the competitiveness and efficiency of medical organizations, is the implementation of the OECD Corporate Governance Principles. At the moment, most of the medical organizations of Kazakhstan are transferred to state enterprises on the basis of economic management with supervisory boards. Key words: medical organization, corporate governance, state-owned enterprises on the right of economic management, supervisory board, rating score, levels of assessment of corporate governance.
Prospects for Planning Development of a Reception and Diagnostic Department of a Children’s Hospital
Authors:   Surgeon of the admission and diagnostic department of the Multidisciplinary Children’s Hospital No.2 of Nur-Sultan city, Mussirov Nurlan , Sultanbekova Galiya ,   Financial Director of CAICC LLP, Professor of Almaty Management University
Published: December 2020

This article discusses the current state of children’s medical organizations on the example of the reception and diagnostic center of the city children’s hospital in Nur-Sultan. The main goals and objectives of planning the development of children’s medical institutions are also presented. In addition, measures are shown to improve the work of the children’s clinic. Improving the efficiency of health care in Kazakhstan is carried out within the framework of government programs developed to improve the key indicators of the country’s health care. Key words: healthcare, medical institutions, children’s hospital, Kazakhstan.
About the experience of creating a triage training zone at the Department of Simulation Technologies of Semey Medical University
Authors:   Head of the Department of Simulation Technologies, Semey Medical University, Mukanova Dinara , Kovylina Regina ,   Lecturer of the Department of Simulation Technologies, Semey Medical University
Published: December 2020

The first training zone of triages in Kazakhstan was opened in the Training and Clinical Center of the State Medical University of Semey (Department of Simulation Technologies of Semey Medical University). The functional design of the emergency medical care unit is an innovation in education and healthcare, modernization of the educational process in accordance with modern requirements. This innovation is aimed at reducing the congestion of the reception rooms by patients who are forced to wait for a long time to see a doctor, as well as providing a qualitative assessment of the severity of the emergency condition in patients.
Quimiorradioterapia no doente idoso com cancro do pulmão, onde nos encontramos? – O retrato de um centro
Authors:   Serviço de Radioterapia do Instituto Português de Oncologia de Lisboa, Varela Raquel , Travancinha Catarina ,   Serviço de Radioterapia do Instituto Português de Oncologia de Lisboa, Ferreira Filipa ,   Serviço de Oncologia Médica do Hospital São Francisco Xavier, CHLO, Americano Pedro ,   Serviço de Pneumologia do Centro Hospitalar Universitário do Algarve, Labareda Miguel ,   Serviço de Radioterapia do Instituto Português de Oncologia de Lisboa, Almodovar Maria ,   Serviço de Pneumologia do Instituto Português de Oncologia de Lisboa
Published: December 2020

Introdução: O cancro do pulmão (CP) é a neoplasia com maior incidência em todo o mundo e a primeira causa de morte por doença oncológica a nível mundial. O atual standard of care para o CP estádio III é a radioterapia (RT) concomitante com quimioterapia (QT) com dupleto de platina. Apesar da idade média ao diagnóstico ser cerca de 70 anos, o tratamento ideal nos idosos neste estádio, não está ainda completamente estabelecido, por se tratar de um subgrupo de doentes raramente incluídos em ensaios clínicos. Assim, o valor da quimioradioterapia (QRT) nos idosos é ainda pouco claro. Objectivos: Caracterização dos doentes com CP submetidos a QRT, comparação dos subgrupos com idade <65 (grupo A) e ≥65 anos (grupo B) com análise de fatores de prognóstico, sobrevivência global (SG) e sobrevivência livre de progressão (SLP). Material e métodos: Estudo retrospectivo, observacional e unicêntrico que incluiu os doentes com CP submetidos a QRT num hospital português durante 10 anos (2007 -2017). Análise estatística efetuada no programa SPSS v25, utilizando o teste de Kaplan‑Meier para análise de sobrevivência. Valores de p≤0.05 foram considerados estatisticamente significativos. Resultados: Foram incluídos 97 doentes (idades 39 -78 anos), 57 no grupo A e 40 no B. Não foram registadas diferenças estatisticamente significativas entre os grupos a nível de género, performance status, subtipo histológico, estadiamento TNM, comorbilidades, fracionamento e dose de RT, número de ciclos de QT e toxicidade à terapêutica. A única diferença constatada foi relativamente aos fármacos utilizados (p=0.0387), predominando a utilização de cisplatina e vinorrelbina no grupo A (59.6%) e carboplatina e paclitaxel no B (60.0%). Houve ainda diferença na SG (37.1 vs. 27.2 meses; p=0.0449), mas não ao nível da SLP (25.2 vs. 17.2 meses; p=0.0899). Quando avaliado o valor prognóstico, nenhum dos fatores se revelou significativo no grupo B, registando -se apenas uma tendência no número de ciclos de QT (p=0.056). Conclusão: A QRT pode ser uma opção segura e eficaz nos doentes idosos com bom performance status. São necessários estudos que incluam doentes idosos e a sua avaliação de forma dirigida, nomeadamente através dos instrumentos geriátricos desenvolvidos para o efeito.
Sissoo, its Pathogenic Constraints and their Management in Nepal: A review
Authors: Timilsina Sachin , Bhattarai Rajeev , Miya Mahamad Sayab , Gautam Deepak
Published: December 2020

Sissoo (Dalbergia sissoo) is a deciduous tree, native to Nepal and the Indian subcontinent. The tree is traditionally used for making furniture, fodder and herbal medicine. It is also used as shelter-wood, and in conserving soil in degraded areas. This review focuses on the health management practices against pathogenic constraints in sissoo. Literature published till June 2020 was considered to understand the biology of the tree species and associated pathogens apart from understanding the management practices to treat the diseases. Despite the massive significance of this tree, available publications on the pathogenic risks and the strategies to cope with them are unnoticed so far. This article expects to bring together information on sissoo tree’s biology, pathogen attacks and its management. Of various fungal diseases in sissoo, this article deals with only two of the fungal diseases, Fusarium solani and Ganoderma lucidum, which cause dieback and root rot in sissoo, respectively. The findings highlighted can further reinforce the current sissoo management and pathogen control strategies and improve its health to augment high quality timber.
PROCEDURE, RULES FOR OBTAINING AND PROCESSING DOCUMENTS IN CONSTRUCTION
Authors: Cherkun V. , Leshchenko M. , Zyhun A. , Avramenko Y.
Published: December 2020

The resolution of many disputable situations that occur during the construction and operation of buildings and structures is carried out in court by the appointment of a forensic construction and technical expertise. As result of the activity of forensic examination, there is a need to study the design and estimate documentation, determine the types, scope, quality and cost of construction and repair work performed; establishing compliance of their characteristics with the requirements of special codes and rules governing the processes of design, construction, operation, reconstruction during repair, dismantling and disposal of buildings and structures.

The objects of research of construction and technical examination are: buildings, structures, engineering and other equipment and documentation to it, in particular, technical passports, inventory; working projects and working documentation; specifications, explanatory notes to the project; conclusions of the state complex examination; local estimates; general information on resources; agreements or contracts; additional agreements; acts of performed contract works; certificates on performed contract works; reports on regulatory write-off of materials; acts of inspection of hidden works; calendar plans or network schedules; work logs; commissioning acts.

Carrying out construction and technical expertise in this way there is own characteristics and requires constant improvement of methodology. The expert builder must have a thorough knowledge of the regulatory framework for such work and the procedure for maintaining appropriate documentation to determine the type of construction and repair work.

The paper considers the main points of implementation of documents before construction, registration of documentation during construction and documents during the commissioning of the construction object, as well as which regulations provide requirements for their execution.
Reseña: Pablo Boczkowski y Zizi Papacharissi. (Eds). Trump and the Media. Cambridge: The MIT Press (2018)
Authors: Abreu Colombri José Antonio
Published: December 2020

Propuesta de reseña.
Effect of Parents' Characteristics and Perceptions on Basic Immunization in Children at Dr. Zainoel Abidin Banda Aceh
Authors: Susanti Octavina , Thaib T.M. , Andid Rusdi , Yusuf Sulaiman , Anidar Anidar , Ismy Jufitriani , Darnifayanti Darnifayanti
Published: December 2020

Immunization is a form of health intervention that is effective in reducing infant and under-five mortality rates. In Indonesia Aceh is the province with the lowest immunization coverage, where only 20% of Acehnese children receive complete basic immunization. M e n g analysis of the influence of parents' characteristics and perceptions of primary immunization in children in the General Hospital Dr. Zainoel Abidin Banda Aceh. This type of research is descriptive analytic with approach cross sectional using a questionnaire as a research instrument to the parents of the patients in the wards and child polyclinic period from June to July 2020. A sample of 51 people with methods Consecutive sampling. Data analysis used Chi-square test and Fisher exact test. Based on the results of the analysis of the relationship between parental perceptions and completeness of basic immunization, the results were obtained ( p > 0.05 ), for the assessment of the relationship between parental characteristics in the form of age, monthly income level and number of children with completeness of basic immunization in children, the results were obtained ( p > 0.05). , while the characteristics of the level of parental education with completeness of basic immunization in children obtained hacil ( p <0.05). There is an influence of parental characteristics, namely the level of education with completeness of basic immunization in children, while other variables, namely parents' perceptions, parental age, monthly income and number of children in one family do not affect the completeness of basic immunization in children at Dr. Zainoel Abidin Banda Aceh.
Uso de aditivos em dietas para leitões em fase de creche: uma revisão
Authors: Lima Marcelo Dourado de , Lopes Idael Matheus Góes , Silva Kariny Fonseca da , Miranda Hemille Antunes Ferreira , Almeida Anna Christina de , Duarte Eduardo Robson
Published: December 2020

O uso de aditivos em dietas para leitões desmamados na suinocultura industrial tem como intuito diminuir o uso de antimicrobianos na produção suinícola, além de melhorar a saúde intestinal e desempenho produtivo dos animais. Portanto, neste estudo teve-se como objetivo elaborar uma revisão bibliográfica sobre os principais aditivos utilizados em dietas para leitões na fase de creche.  Os aditivos atuam como probióticos e prebióticos, sendo estes essenciais na fase de creche devido aos desafios sanitários que os animais são submetidos, visto que promovem benefícios para a saúde dos animais. O sucesso na utilização dos aditivos na fase de creche está relacionado com a dosagem a ser utilizada e principalmente com o nível de desafio sanitário ao qual os animais são expostos. Alguns resultados de pesquisas nessa área indicam que os aditivos são mais eficientes em animais mais desafiados, o que justifica a variabilidade de resultados encontrados na literatura. Alguns estudos demonstram que o mecanismo de ação dos aditivos pode reduzir o uso de antimicrobianos nas dietas de leitões em fase de creche, além de agregar melhores resultados de desempenho zootécnico. De acordo com a revisão realizada, conclui-se que a utilização de aditivos em dietas de leitões em período de creche, pode garantir melhores índices produtivos dos animais, além de se apresentarem como boas alternativas frente ao uso de antibióticos.
Effects of Mutagens on Morphological traits of Psoralea corylifolia-A Medicinally
Important Plant
Authors: Chaudhari Ajey Karan , Singh Anand Prakash , Chaudhary B R
Published: December 2020

Mutation breeding like in other plants can significantly strengthen medicinal plants breeding programs and help to produce novel varieties with higher yield potential and improved yield quality. The dry and healthy seeds of P. corylifolia IC 111228 were subjected to mutagenic treatments namely ethyl methane sulphonate (EMS) and sodium azide (SA). The treatment concentrations 15mM, 30mM, 45mM and 60mM of EMS and 1mM, 2mM, 3mM and 4mM of SA were chosen to evaluate the mutagenic potential in either case. The morphological traits were evaluated in M1 generation viz. plant height, days to flowering
initiation, seed yield/plant and 100-seed weight. In EMS treatment 15 mM increased the plant height and seed yield, while in SA treatment 4 mM increased the seed yield/plant and 100-seed yield.
Use of Clove extract against the larvae of Aedes (Culicidae: Diptera) mosquitoes
Authors: Baghel C.L. , Gupta M.K. , JHA A.K.
Published: December 2020

Insecticides have been commonly used to vector control. The current study has been made to evaluate the effect of Syngium aromaticum (clove oil) against the larvae of Aedes for their biocidal activity. The oil can be used in domestic container due to its biodegradable and unharmful nature. The toxicity of insecticides affects the environment. Antilarval activities were studied using clove oil with methanol and ether separately in different concentrations. The bioassay has been made against the third / early fourth stage larvae of Aedes mosquito. These were exposed with control and clove oil concentrations of 20ppm, 30ppm and 50ppm. The bioassay test has been made or the first time to know the efficacy of clove oil against mosquito larvae and check the mortality within 24 hrs.
DESAIN MODEL STEM-FC PADA PERKULIAHAN GEOSAINS
Authors: Ardianto Didit , Permanasari Anna , Firman Harry , Ramalis Taufik Ramlan
Published: December 2020

Artikel ini membahas tentang desian STEM-FC yang dikembangkan pada perkuliahan geosains bagi mahasiswa calon guru. Pengembangan dilakukan dengan menggunakan metode developmental research. Namun, pada artikel ini tidak membahas secara keseluruhan tahapan pengembangan. Pembahasan difokuskan pada tahap developing yang menitik beratkan pada uji coba model. Partisipan yang terlibat yaitu 25 mahasiswa calon guru SD yang sedang mengikuti perkuliahan ilmu bumi dan antariksa. Desain STEM-FC yang dikembangkan mampu memfasilitasi mahasiswa untuk belajar secara aktif. Selain itu desain perkuliahan yang dikembangkan juga membuat mahasiswa menjai antusias dalam belajar geosains.
The incidence of public security policies on political risk
Authors: Hernández-Gutiérrez José-Carlos
Published: December 2020

The aim of this work is to make explicit the relationship between political risk
and public security policies. The theory through which such a link is established
is the theory of dangerous places. These places are characterized by high levels
of unemployment, poverty, high demographic density, etc. These phenomena
are also threats to security. That there are territories that have such characteristics
is, in a way, the responsibility of governments. Thus, they are also responsible
for the thousands of companies that annually incur millions in losses due
to business victimization. For this reason, it seems essential to take into account
the current or future governments’ crime prevention public policy approaches,
since their decisions can minimize the losses borne by the victimized companies.
Mechanical and Physical Regulation of Fibroblast–Myofibroblast Transition: From Cellular Mechanoresponse to Tissue Pathology
Authors: D'Urso Mirko , Kurniawan Nicholas A.
Published: December 2020

Fibroblasts are cells present throughout the human body that are primarily responsible for the production and maintenance of the extracellular matrix (ECM) within the tissues. They have the capability to modify the mechanical properties of the ECM within the tissue and transition into myofibroblasts, a cell type that is associated with the development of fibrotic tissue through an acute increase of cell density and protein deposition. This transition from fibroblast to myofibroblast—a well-known cellular hallmark of the pathological state of tissues—and the environmental stimuli that can induce this transition have received a lot of attention, for example in the contexts of asthma and cardiac fibrosis. Recent efforts in understanding how cells sense their physical environment at the micro- and nano-scales have ushered in a new appreciation that the substrates on which the cells adhere provide not only passive influence, but also active stimulus that can affect fibroblast activation. These studies suggest that mechanical interactions at the cell–substrate interface play a key role in regulating this phenotype transition by changing the mechanical and morphological properties of the cells. Here, we briefly summarize the reported chemical and physical cues regulating fibroblast phenotype. We then argue that a better understanding of how cells mechanically interact with the substrate (mechanosensing) and how this influences cell behaviors (mechanotransduction) using well-defined platforms that decouple the physical stimuli from the chemical ones can provide a powerful tool to control the balance between physiological tissue regeneration and pathological fibrotic response.
Proteomic Reveals Reasons for Acquired Drug Resistance in Lung Cancer Derived Brain Metastasis Based on a Newly Established Multi-Organ Microfluidic Chip Model
Authors: Xu Mingxin , Wang Yingyan , Duan Wenzhe , Xia Shengkai , Wei Song , Liu Wenwen , Wang Qi
Published: December 2020

Anti-tumor drugs can effectively shrink the lesions of primary lung cancer; however, it has limited therapeutic effect on patients with brain metastasis (BM). A BM preclinical model based on a multi-organ microfluidic chip has been established proficiently in our previous work. In this study, the BM subpopulation (PC9-Br) derived from the parental PC9 cell line was isolated from the chip model and found to develop obvious resistance to antineoplastic drugs including chemotherapeutic agents (cisplatin, carboplatin, pemetrexed) and tyrosine kinase inhibitors (TKIs) which target epidermal growth factor receptor (EGFR); this suggested that the acquisition of drug-resistance by brain metastatic cells was attributable to the intrinsic changes in PC9-Br. Hence, we performed proteomic and revealed a greatly altered spectrum of BM protein expression compared with primary lung cancer cells. We identified the hyperactive glutathione (GSH) metabolism pathway with the overexpression of various GSH metabolism-related enzymes (GPX4, RRM2, GCLC, GPX1, GSTM4, GSTM1). Aldehyde dehydrogenases (ALDH1A1, ALDH3A1) were also found to be upregulated in BM. What's more, loss of EGFR and phosphorylated EGFR in PC9-Br gave reasons for the TKIs resistance. Collectively, our findings indicated potential mechanisms for the acquirement of drug resistance occurred in BM, providing new strategies to overcome therapeutic resistance in lung cancer BM.
Elucidating the Role of Virulence Traits in the Survival of Pathogenic E. coli PI-7 Following Disinfection
Authors: Sivakumar Krishnakumar , Lehmann Robert , Rachmadi Andri Taruna , Augsburger Nicolas , Zaouri Noor , Tegner Jesper , Hong Pei-Ying
Published: December 2020

Reuse and discharge of treated wastewater can result in dissemination of microorganisms into the environment. Deployment of disinfection strategies is typically proposed as a last stage remediation effort to further inactivate viable microorganisms. In this study, we hypothesize that virulence traits, including biofilm formation, motility, siderophore, and curli production along with the capability to internalize into mammalian cells play a role in survival against disinfectants. Pathogenic E. coli PI-7 strain was used as a model bacterium that was exposed to diverse disinfection strategies such as chlorination, UV and solar irradiation. To this end, we used a random transposon mutagenesis library screening approach to generate 14 mutants that exhibited varying levels of virulence traits. In these 14 isolated mutants, we observed that an increase in virulence traits such as biofilm formation, motility, curli production, and internalization capability, increased the inactivation half-lives of mutants compared to wild-type E. coli PI-7. In addition, oxidative stress response and EPS production contributed to lengthening the lag phase duration (defined as the time required for exposure to disinfectant prior to decay). However, traits related to siderophore production did not help with survival against the tested disinfection strategies. Taken together, the findings suggested that selected virulence traits facilitate survival of pathogenic E. coli PI-7, which in turn could account for the selective enrichment of pathogens over the non-pathogenic ones after wastewater treatment. Further, the study also reflected on the effectiveness of UV as a more viable disinfection strategy for inactivation of pathogens.
ATR Kinase Is a Crucial Player Mediating the DNA Damage Response in Trypanosoma brucei
Authors: Marin Paula Andrea , Obonaga Ricardo , Pavani Raphael Souza , da Silva Marcelo Santos , de Araujo Christiane Bezerra , Lima André Arruda , Avila Carla Cristi , Cestari Igor , Machado Carlos Renato , Elias Maria Carolina
Published: December 2020

DNA double-strand breaks (DSBs) are among the most deleterious lesions that threaten genome integrity. To address DSBs, eukaryotic cells of model organisms have evolved a complex network of cellular pathways that are able to detect DNA damage, activate a checkpoint response to delay cell cycle progression, recruit the proper repair machinery, and resume the cell cycle once the DNA damage is repaired. Cell cycle checkpoints are primarily regulated by the apical kinases ATR and ATM, which are conserved throughout the eukaryotic kingdom.Trypanosoma bruceiis a divergent pathogenic protozoan parasite that causes human African trypanosomiasis (HAT), a neglected disease that can be fatal when left untreated. The proper signaling and accuracy of DNA repair is fundamental toT. bruceinot only to ensure parasite survival after genotoxic stress but also because DSBs are involved in the process of generating antigenic variations used by this parasite to evade the host immune system. DSBs trigger a strong DNA damage response and efficient repair process inT. brucei, but it is unclear how these processes are coordinated. Here, by knocking down ATR inT. bruceiusing two different approaches (conditional RNAi and an ATR inhibitor), we show that ATR is required to mediate intra-S and partial G1/S checkpoint responses. ATR is also involved in replication fork stalling, is critical for H2A histone phosphorylation in a small group of cells and is necessary for the recruitment and upregulation of the HR-mediated DNA repair protein RAD51 after ionizing radiation (IR) induces DSBs. In summary, this work shows that apical ATR kinase plays a central role in signal transduction and is critical for orchestrating the DNA damage response inT. brucei.
Earthquake Source Characteristics and S-Wave Propagation Attenuation in the Junction of the Northwest Tarim Basin and Kepingtage Fold-and-Thrust Zone
Authors: Wang Hongwei , Wen Ruizhi
Published: December 2020

We separated the propagation path attenuation and source spectra from the S-wave Fourier amplitude spectra of the observed ground motions recorded during 46 small-to-moderate earthquakes in the junction of the northwest Tarim Basin and Kepingtage fold-and-thrust zone, mainly composed of two Jiashi seismic sequences in 2020 and 2018. Slow seismic wave decay was observed as the distance increased, while the quality factor regressed as 60.066f0.988for frequencyf= 0.254–30 Hz reflects the strong anelastic attenuation in the study region. We estimated the stress drops for the 46 earthquakes under investigation from the preferred corner frequencies and seismic moments by fitting the inverted source spectra and the theoretical ω-square model. The relationship between seismic moment and corner frequency and the dependence of the stress drop on the moment magnitude reveal the breakdown of earthquake self-similar scaling for the events in this study. The temporal variation in stress drops indicates that the mainshock plays a short-term role in the source characteristics of the surrounding earthquakes. Aftershocks immediately following the mainshock show a low stress release and then gradually recover in a short time. The healing process for the fractured fault in the mainshock may be one reason for the stress drop recovery of the aftershock. The foreshock with the low stress release occurring in the high-heterogeneity fault zone may motivate the following occurrence of the largest magnitude mainshock with a high stress drop. We inferred that the foreshock-mainshock behavior, including several moderate events, may be predisposed to occur in our study region characterized by an inhomogeneous crust.