bluuebunny/crossref_metadata_2025 huggingface dataset:
Cyp24a1 Attenuation Limits Progression of BrafV600E-Induced Papillary Thyroid Cancer Cells and Sensitizes Them to BRAFV600E Inhibitor PLX4720
Authors: Zou Minjing , Baitei Essa Y. , BinEssa Huda A. , Al-Mohanna Futwan A. , Parhar Ranjit S. , St-Arnaud René , Kimura Shioko , Pritchard Catrin , Alzahrani Ali S. , Assiri Abdullah M. , Meyer Brian F. , Shi Yufei
Published: February 2017

CYP24A1, the primary inactivating enzyme for vitamin D, is often overexpressed in human cancers, potentially neutralizing the antitumor effects of calcitriol, the active form of vitamin D. However, it is unclear whether CYP24A1 expression serves as a functional contributor versus only a biomarker for tumor progression. In this study, we investigated the role of CYP24A1 on malignant progression of a murine model of BrafV600E-induced papillary thyroid cancer (PTC). Mice harboring wild-type Cyp24a1 (BVECyp24a1-wt) developed PTC at 5 weeks of age. Mice harboring a homozygous deletion of Cyp24a1 (BVECyp24a1-null) exhibited a 4-fold reduction in tumor growth. Notably, we found the tumorigenic potential of BVECyp24a1-null-derived tumor cells to be nearly abolished in immunocompromised nude mice. This phenotype was associated with downregulation of the MAPK, PI3K/Akt, and TGFβ signaling pathways and a loss of epithelial–mesenchymal transition (EMT) in BVECyp24a1-null cells, associated with downregulation of genes involved in EMT, tumor invasion, and metastasis. While calcitriol treatment did not decrease cell proliferation in BVECyp24a1-null cells, it strengthened antitumor responses to the BRAFV600E inhibitor PLX4720 in both BVECyp24a1-null and BVECyp24a1-wt cells. Our findings offer direct evidence that Cyp24a1 functions as an oncogene in PTC, where its overexpression activates multiple signaling cascades to promote malignant progression and resistance to PLX4720 treatment. Cancer Res; 77(8); 2161–72. ©2017 AACR.
Dionysius of Halicarnassus on Rome’s Greek Musical Heritage
Authors: Barker Andrew
Published: February 2017

Dionysius tells us that his main objective in writing theAntiquitates Romanae, his massive history of Rome, was to convince his fellow-Greeks that the Romans were by origin Greeks themselves, that in their customs they preserved central features of the noble Greek culture they had inherited, and that the people under whose regime the Greeks now lived were therefore not to be despised or resented as barbarians. This paper examines some of the allusions to music scattered through the text, considering the extent and nature of the support they give to this thesis, and asking whether there is anything to be learned from them about the characteristics of the culture which Dionysius regards as both admirable and essentially Greek, and which he represents as manifesting itself among the Romans from the earliest times and persisting among them to the present day.
Contribution to the Uropodina mites of Peru (Acari: Mesostigmata)
Authors: KONTSCHÁN JENŐ , FRIEDRICH STEFAN
Published: February 2017

Soil dwelling Uropodina mites were collected from a primary lowland rainforest in Amazonian Peru. The species found belong to three different families. A new diagnosis and the type genus of Tetrasejaspidae fam. nov. are given, and the family is recorded from Peru for the first time on the basis of Tetrasejaspis sellnicki Hirschmann, 1973. Two rotundabaloghid mites were collected (Rotundabaloghia (Circobaloghia) magna Hirschmann, 1992 and Rotundabaloghia (Circobaloghia) iquitosensis Hirschmann, 1992), both already reported from Peru. A new species (Origmatrachys peruensis sp. nov.) from the family Trachyuropodidae was collected in large numbers from soil, and is described on the basis of females, males, nymphs and larvae. This is the first description of the protonymphs and larvae of Origmatrachys. The new species differs from the previously described ones in the basis of sculptural pattern of dorsal, ventral, sternal shields and the length of the setae in the central part of the dorsal shield. A new key to the known adults and deutonymphs of Origmatrachys is given.
A combined screening and discussion clinic for fingolimod▾: results of a patient satisfaction survey
Authors: Coulhoun Samantha , Lessiter Sharon , Roberts Megan
Published: February 2017

The multiple sclerosis (MS) nurse team at Queen Elizabeth Hospital, Birmingham routinely seek service user feedback. This article discusses the implementation of the fingolimodt pathway and the establishment of a one-stop screening and information clinic as part of this. Patients who attended were surveyed to find out whether the service was meeting their needs. The patient feedback for the new service has been very positive and the clinical outcomes encouraging. The results are reported here. The service continues to evolve and to put service users at the heart of its development.
Safeguarding vulnerable adults
Authors: Griffith Richard
Published: February 2017

In this article Richard Griffith sets out nurses’ duty to safeguard vulnerable adults from abuse and, with adult abuse continuing to increase, how nurses are well placed to identify and act to safeguard the vulnerable
Mastering maths starts with a great deal of talking
Authors: Chilvers Di
Published: February 2017

Following the success of the Talk for Reading partnership, the natural progression was to look at how working in clusters of schools and settings can help to improve our mathematics provision for children.
What does child-centred really mean?
Authors: Campbell-Barr Verity
Published: February 2017

Child-centred is a construct that has a rich history. This has resulted in different interpretations that can be both complementary and contradictory for those who work in early education and care, giving rise to the question – what does it mean to be child-centred?
The most important phase of all
Authors: Cowley Sue
Published: February 2017

We are always told, in passing, or when the government is under fire, that the early years is the most crucial phase of a child's life, and yet the reality is that the sector is viewed very much like the poor cousin.
Trying hard to reach out
Authors: James Karen
Published: February 2017

This four-part series of articles will explore ways of making Early Years Pupil Premium work for children and settings. Karen James explains how ‘hard to reach’ parents were targeted in Hertfordshire.
Streaming dreams into the realm of what is possible
Authors: Clarke Jenni
Published: February 2017

Jenni Clarke continues her exploration of interconnecting building bricks in relation to different aspects of learning. This month's focus is on how playing with these bricks helps children to be more creative.
Research roundup
Authors: Costello John
Published: February 2017

Synopses of a selection of recently published research articles of relevance to palliative care.
Research Roundup
Authors: Winter George
Published: February 2017

George Winter provides an overview of recently published articles that may be of interest to practice nurses. Should you wish to look at any of the papers in more detail, a full reference is provided.
CPD article - Feeding ferrets
Authors: Bourne Debra
Published: February 2017

Ferrets are small obligate carnivores. Even more than cats they are designed for a meat diet, and their short digestive system leads to rapid food throughput. Ferrets need to be fed high-quality diets with high levels of animal-origin protein, given little and often, with stashed food removed before it spoils. A varied diet is recommended to avoid the ferret's food preference becoming fixed. Feeding of inappropriate sweet, high-carbohydrate and high-fibre foods should be avoided. Feeding provides an excellent opportunity for environmental enrichment, which should be used as much as possible.
Approach to the companion animal cancer patient: current therapies
Authors: Adams Vicki J
Published: February 2017

As one of the most treatable of all the chronic diseases, a diagnosis of cancer ultimately leads to a discussion of treatment options, including therapy directed at the cancer as well as any associated pain or other clinical signs, including paraneoplastic disease, and any comorbidity. The goal of treatment is to achieve as good a quality of life as possible for as long as possible. Given that curative-intent definitive treatment is not always an option, palliative treatment is available and can make the animal comfortable during the latter part of life. The aim of this article is to describe the various cancer therapies available, focusing on the role the veterinary nurse can play in facilitating communication between owner and veterinary surgeon about treatment options and quality of life of the animal.
Update on canine obesity: the One Health approach
Authors: Linder Deborah
Published: February 2017

The One Health approach to weight loss considers the aspects of the human–animal bond that can be harnessed to achieve physical benefits for both the pet and their owner.
Undercover fear of elderly people in nursing homes: Death anxiety and depression
Authors: Bektaş Hicran , Körükcü Öznur , Kabukcuoğlu Kamile
Published: February 2017

Aim: To find out the level of death anxiety and depression level among Turkish elderly people.Methods: This research was carried out on 106 elderly people aged 60 years and older from three different nursing homes. Descriptive statistics, one-way ANOVA, t-test, Cronbach’s alpha coefficient, and correlations were used for the analyses.Results: The 25.4% of elderly were between 65-69 years old, and included most of the elderly who were male (83%), single (92.5%) and retired (35.8%).The overall mean on depression was 14.43, and the death anxiety was 7.57.  Mild depression was found in 69.8%, and no symptoms of depression were reported by 16% of the subjects. A positive correlation was found between total score of GDS and TDAS (r: 0.304, p<0.01).Conclusion: Healthcare professionals working with elderly people in nursing homes should be aware about death anxiety of the elderly.
Successful Antecedents of Women Entrepreneurs: A Case of Underdeveloped Nation
Authors: Batool Hira , Ullah Kalim
Published: February 2017

Women as the emergent economic power influence the shape of the global economy. For the prosperity of the nation, it is important that women should be involved in the job creation activities rather than providing with the job opportunities, as businesses are more time flexible than being an employee especially for women; where they are playing multiple roles at a time. In order to work on the efficiency and efficacy of the entire women, this paper studied the relationship between successful antecedent such as motivation, personality trait, creativity, access to finance, family factors and success of women entrepreneurial endeavors was being assessed. For this purpose data were collected from women entrepreneurs through a purposive sampling technique by using five likert scale questionnaire. Analysis of the study revealed that antecedents plays a positive role in the success of women entrepreneurial endeavors, however family support also appears to have a strong mediation effect on the success of women entrepreneurial endeavors but a negative value of beta indicates that women in under-developed society generally are not warmly encouraged by the family to opt for entrepreneurial endeavors. So, there is a need to work on this aspect in order to encourage other female participation in the economic growth.
Quality Uncertainty Erodes Trust in Science
Authors: Vazire Simine
Published: February 2017

When consumers of science (readers and reviewers) lack relevant details about the study design, data, and analyses, they cannot adequately evaluate the strength of a scientific study. Lack of transparency is common in science, and is encouraged by journals that place more emphasis on the aesthetic appeal of a manuscript than the robustness of its scientific claims. In doing this, journals are implicitly encouraging authors to do whatever it takes to obtain eye-catching results. To achieve this, researchers can use common research practices that beautify results at the expense of the robustness of those results (e.g., p-hacking). The problem is not engaging in these practices, but failing to disclose them. A car whose carburetor is duct-taped to the rest of the car might work perfectly fine, but the buyer has a right to know about the duct-taping. Without high levels of transparency in scientific publications, consumers of scientific manuscripts are in a similar position as buyers of used cars – they cannot reliably tell the difference between lemons and high quality findings. This phenomenon – quality uncertainty – has been shown to erode trust in economic markets, such as the used car market. The same problem threatens to erode trust in science. The solution is to increase transparency and give consumers of scientific research the information they need to accurately evaluate research. Transparency would also encourage researchers to be more careful in how they conduct their studies and write up their results. To make this happen, we must tie journals’ reputations to their practices regarding transparency. Reviewers hold a great deal of power to make this happen, by demanding the transparency needed to rigorously evaluate scientific manuscripts. The public expects transparency from science, and appropriately so – we should be held to a higher standard than used car salespeople.
Acute mesenteric ischemia and hepatic infarction after treatment of ectopic Cushing’s syndrome
Authors: Takayasu Shinobu , Murasawa Shingo , Yamagata Satoshi , Kageyama Kazunori , Nigawara Takeshi , Watanuki Yutaka , Kimura Daisuke , Tsushima Takao , Sakamoto Yoshiyuki , Hakamada Kenichi , Terui Ken , Daimon Makoto
Published: February 2017

Patients with Cushing’s syndrome and excess exogenous glucocorticoids have an increased risk for venous thromboembolism, as well as arterial thrombi. The patients are at high risk of thromboembolic events, especially during active disease and even in cases of remission and after surgery in Cushing’s syndrome and withdrawal state in glucocorticoid users. We present a case of Cushing’s syndrome caused by adrenocorticotropic hormone-secreting lung carcinoid tumor. Our patient developed acute mesenteric ischemia after video-assisted thoracoscopic surgery despite administration of sufficient glucocorticoid and thromboprophylaxis in the perioperative period. In addition, our patient developed hepatic infarction after surgical resection of the intestine. Then, the patient was supported by total parenteral nutrition. Our case report highlights the risk of microthrombi, which occurred in our patient after treatment of ectopic Cushing’s syndrome. Guidelines on thromboprophylaxis and/or antiplatelet therapy for Cushing’s syndrome are acutely needed.

Learning points:

The present case showed acute mesenteric thromboembolism and hepatic infarction after treatment of ectopic Cushing’s syndrome.

Patients with Cushing’s syndrome are at increased risk for thromboembolic events and increased morbidity and mortality.

An increase in thromboembolic risk has been observed during active disease, even in cases of remission and postoperatively in Cushing’s syndrome.

Thromboprophylaxis and antiplatelet therapy should be considered in treatment of glucocorticoid excess or glucocorticoid withdrawal.
“Popular” Social Work In Extremis: Two case studies on collective welfare responses to social crisis situations
Authors: Lavalette Michael , Ioakimidis Vasilios
Published: February 2017

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Kurianti tėvystė - motinystė ir šiandienė bevaikystės kultūra
Authors: Vaitoška Gintautas
Published: February 2017

Klausimas „Ar verta turėti vaikų“, pasak prancūzų filosofo Gabrielio Marcelio, Vakarų visuomenėje yra naujas. Turėdamas laisvę paneigti prigimtinę gyvenimo duotybę – jungtuvinį žmogaus ir gyvenimo ryšį – individas ir visuomenė patiria nuobodulį – egzistencinę tuštumą. Ši problema tiksliau aprašoma kognityvaus, ne moralinio trūkumo terminu: gyvename gyvenimo vertės eklipsės laikais. Šis pasaulio spalvos pritemimas nulemtas daugelio priežasčių, tačiau viena iš svarbiausių yra savęs bei vyro ir moters santykio nuskurdinimas iki seksualumo – termino, kuriame vyrauja utilitarinė dimensija. Kad vyro ir moters galią pradėti gyvybę tiksliau yra vadinti „generatyvumu“ (arba „gimtiškumu“), sutaria tokios palyginti skirtingos pažiūrų sistemos, kaip antai klasikinė tomistinė antropologija, Rytų žmogaus supratimas (Vydūnas) ir psichoanalizė (Erikias Eriksonas). Kad tokia antropologija yra adekvati – Jono Pauliaus II – terminas, parodo ir skaitlingi pastarųjų dešimtmečių neurobiologiniai tyrimai, moters grožį aiškiai susiejantys su jos vaisingumu. Tačiau pastarojo vertės suvokimą apsunkina, pasak Dawsono, Vakarų moksle įsigalėjusi pozityvistinė tradicija; vaisingumą suvokiant remiantis biologijos žiniomis ir medicinos tyrimais, vyrauja „biologijos“ semantika, kuri „nebepamena“, kad moters grožis susijęs su jos potencialu atverti ar uždaryti gyvenimo vartus. Atvirumas vaikams praturtina pačius tėvus „ego ribų išplėtimu“, o vaikų ir, vadinasi, visos visuomenės vystymuisi pirmieji metai kuria emocinės sistemos pamatus, kuriuos vėliau galima sustiprinti tik investuojant daug lėšų į pedagogines, medicinos ir socialines paslaugas to pamato neturintiems. Suvokti ir paremti motinystę ir tėvystę per pirmąjį jaunos šeimos gyvenimo dešimtmetį yra vienintelė valstybės politika, kurią būtų galima pavadinti tikrai pragmatiška
Effect of two low doses of prostaglandin F2α on luteolysis in dairy cows
Authors: Liu Tsung-Ching , Ho Chia-Yu , Chan Jacky Peng-Wen
Published: February 2017

In this preliminary study, we determined the effect of a modified method involving the administration of two low doses of prostaglandin F2α (PGF2α) at an interval of 24 h on luteolysis in dairy cows, and compared it with the standard single-dose method. Twenty-six cows were assigned to three groups treated with two low doses (TLD group, n = 10), one standard dose (SD group, n = 10), and one low dose (OLD group, n = 6) on day 9 to 10 of the oestrous cycle (day 0 = the day of PGF2α administration). Their serum progesterone (P4) levels and corpus luteum (CL) sizes were measured daily from day 0 to 4 to assess CL regression. The results indicated that the proportion of complete luteolysis, indicating a P4 value ≤ 1 ng/mL on day 3, was higher in the TLD group (100.0%) than in the SD (60.0%) and OLD (66.7%) groups. Ultrasonically detected changes in the CL area correlated with the shifts in the P4 values in both the TLD and the SD groups. The remaining CL area was significantly smaller in the TLD group (17.8% ± 3.3%) than in the SD or OLD group on day 4. Thus, we concluded that the proportion of luteolysis in cows was increased with two low doses of PGF2α as compared to a single PGF2α dose, indicating the necessity of the second dose of PGF2α. However, further studies with larger sample sizes in the field are required.
Sensitivity of the meiotic stage to hyperthermia during in vitro maturation of porcine oocytes
Authors: Nishio Katsutoshi , Yamazaki Mado , Taniguchi Masayasu , Besshi Kazuhiko , Morita Fumio , Kunihara Toshiki , Tanihara Fuminori , Takemoto Tatsuya , Otoi Takeshige
Published: February 2017

The present study was conducted to clarify whether the meiotic stage of porcine oocytes has the highest sensitivity to hyperthermia during in vitro maturation by evaluating meiotic competence and DNA damage. Oocytes were exposed to 41 °C for 12 h at various intervals during 48 h of maturation culture. When the oocytes were exposed to 41 °C from 12 to 24 h of the maturation culture, the proportion of oocytes reaching metaphase II (MII) decreased as compared to the control oocytes cultured at 38.5 °C (P < 0.05). Moreover, the proportions of DNA fragmentation in all oocytes exposed to 41 °C in each culture period after 12 h from the start of maturation culture were significantly higher (P < 0.05) than for the control oocytes. When the meiotic stage of oocytes cultured at 38.5 °C between 12 and 24 h was examined, the majority of oocytes remained at the germinal vesicle (GV) stage at 12 h and approximately half of the oocytes reached metaphase I (MI) at 24 h. These results indicate that the meiotic stage of porcine oocytes having the highest sensitivity to hyperthermia during in vitro maturation is a transition period from the GV stage to the MI stage.
DUGAAN UPWELLING BERDASARKAN ANALISIS KOMPARATIF CITRA SEBARAN SUHU PERMUKAAN LAUT DAN KLOROFIL-A DI TELUK TOMINI
Authors: Amri Khairul , Suwarso Suwarso , Herlisman Herlisman
Published: February 2017

Penelitian dugaan upwelling di perairan Teluk Tomini berdasarkan pada analisis komparatif citra satelit telah dilakukan pada 2003 sampai dengan 2004.
PENDUGAAN POLA DISTRIBUSI SPASIO-TEMPORAL TARGET STRENGTH IKAN PELAGIS DENGAN METODE AKUSTIK DI PERAIRAN TELUK TOMINI
Authors: Wudianto Wudianto , Arnaya I Nyoman , Natsir Mohammad , Herdiana Dian
Published: February 2017

Penelitian pola distribusi target slrerglh ikan pelagis di perairan Teluk Tomini dilakukan pada bulan Juli sampai dengan Agusfus 2003. Hasil penelitian menunjukkan nilai target strength ikan pelagis berkisar antara - 60 sampai dengan -30 dB, dengan nilai dominan antara -60 sampai dongan -54 dB.
Composition of Fatty Acids in Evaluation of Sea Cucumber Potency for Nutraceutical Product Development
Authors: Susilowati Rini , Pratitis Asri , Januar Hedi Indra
Published: February 2017

Unsaturated fatty acid in food has an effect to improve human health, while saturated fatty acid has the opposite impact. Ratio between both types of fatty acids is important to evaluate the biological material for nutraceutical product development. This paper aimed to evaluate the nutraceutical potency of sea cucumber from Kendari Bay Waters, South East Sulawesi, based on their fatty acids composition. The analysis was conducted by the 1H-NMR (Hidrogen-Nuclear Magnetic Resonance) method. Several species within 4 genera (Holothuria, Bohadschia, Actinopyga, and Stichopus) were selected as the subject of the study. Comparison of fatty acid composition has been done in genera level, the preliminary study found that variation between species among the same genera was insignificant (p >0.05). Results of the study detected that Holothuria contained with an even ratio of Poly Unsaturated Fatty Acids (PUFA) and Saturated Fatty Acids (SFA), but Actinopyga was detected with low PUFA/SFA ratio. It may suggest that Holothuria from this region is the most potential raw material for nutraceutical product development. Meanwhile, precaution is needed for genera that contained with low PUFA/SFA ratio. Furthermore, comparison with other studies detected that fatty acids composition is not morphological specific, but vary, according to food viability, environmental and geographic location. Therefore, preliminary screening is important in evaluation of sea cucumber material for nutraceutical product development.
Bioassay-Guided Isolation of an Antibacterial Compound from the Indonesian Soft Coral
Authors: Putra Masteria Yunovilsa , Saparhadi Ahmad , Karim Firmansyah , Murniasih Tutik , Swasono Respati Tri
Published: February 2017

With the aim of searching for new antibacterial compound from marine soft corals, the investigation had been conducted on antibacterial activity of an extract from soft corals Sarcophyton trocheliophorum in the n-hexane, ethyl acetate, n-butanol, and aqueous fractions. The antibacterial activity was tested against two Gram-positive bacteria, viz. Bacillus subtilis (ATCC 6633) and Staphylococcus aureus (ATCC 25923), and two Gram-negative bacteria, viz. Escherichia coli (ATCC 25922) and Vibrio cholerae (ATCC 14035) using the agar disc diffusion assay. Among them, the n-hexane fraction was the most active against three tested bacteria, viz. Bacillus subtilis, Staphylococcus aureus and Vibrio cholerae at the concentration 125 µg/ml, with inhibition zone 14.2, 18.2, 13.8 mm, respectively. Isolation and purification of the active component from the n-hexane fraction led to a known cembranoid-type diterpene, sarcophytoxide. The chemical structure of the isolated compound was determined by IR, MS and NMR, as well as compared to data from the literature. Sarcophytoxide showed moderate activity against B. subtilis, S. aureus and V. cholerae, with a minimum inhibitory concentration (MIC) of 125, 100, 125 mg/ml, respectively.
Precipitation trends and a daily precipitation concentration index for the mid-Eastern Atlantic (Canary Islands, Spain)
Authors: Máyer P. , Marzol M.V. , Parreño J.M.
Published: February 2017

This paper pursues two objectives: first, to determine the trends of seasonal and annual precipitation in the Canary Islands and, second, to identify trends in the daily precipitation concentration index (CI). For the first objective, we used data from 1970-2013 of 23 rainfall stations located on different islands, after verifying the homogeneity of their series. For the second, the sample was reduced to eleven series since deficiencies in data records of less than 1 mm of daily precipitation were appreciated. We used the nonparametric Mann-Kendall test to determine whether the series showed linear trends in annual and seasonal precipitation and in the values of CI. The seasonal results showed negative trends in spring and winter in almost all the time series considered, especially in the north of Gran Canaria and Tenerife. Conversely, 78% of the series in autumn recorded an increase in the precipitation. The annual balance indicated a decline of rainfall in most of the locations, because of the high concentration of precipitation in winter. Finally, the majority of the time series exhibited a trend toward a greater concentration of daily rainfall, in particular those series located in areas where the main towns are settled, which is an important issue to consider because of severe flooding and other geomorphological processes.
The potential nephrotoxic effect of single tablet of 15 mg primaquine in G6PD deficient Hadoti region population of India
Authors: Khandelia Vikash , Pyarsabadi Pavankumar , Nama Umashankar , Chittora Saurabh , Swami Yogesh , Richariya Hemant
Published: February 2017

Primaquine is used in prevention of relapse of plasmodium vivax and ovale. It is known to cause haemolysis induced acute kidney injury in patients with glucose-6-phosphate dehydrogenase (G-6-PD) enzyme deficiency. Primaquine is widely used in the remote areas of Hadoti region of India by many non-registered practitioners for treatment of febrile illnesses without prior testing of G-6-PD status. Due to this practice, many patients land up with the grave consequences with significant health care burden. We report 8 such cases, which were referred to our hospital, New hospital medical college, Kota, Rajasthan, India. Our study included a series of 8 cases which were referred to our hospital with significantly deranged renal function test due to use of primaquine without prior testing of G-6-PD status. Routine blood investigations including renal function tests and G-6-PD status were measured. In our study, we found that patients with febrile illness and G-6-PD deficiency developed acute kidney injury even with a single tablet of 15 mg of primaquine. The use of even a single dose of 15 mg primaquine may not be safe in population of Hadoti region of India. Hence they should not be exposed to primaquine without prior G-6-PD testing.
Reliability of clinical methods in evaluating patellofemoral pain syndrome with malalignment
Authors: R. H. H. Arjun , Kishan Rama , M. S. Dhillon , Chouhan Devender
Published: February 2017

Background: Diagnosis of patellofemroal pain syndrome has been challenging due to lack of clinical test with better sensitivity and specificity, axial imaging has been considered as the standard modality for evaluation. Patients with anterior knee pain because of patellofemoral pain syndrome can be sub-grouped as those with or without radiological positive parameter for patellar maltracking.  The aim of the present study was to evaluate reliability of clinical tests in two subgroups of patients presenting with patellofemoral pain syndrome.

Methods: 45 knees with anterior knee pain without any episode of patellar instability were evaluated clinically using four standard tests (patellar apprehension test (PAT), eccentric step test (EST), active instability test (AIT) and Waldron’s test. On the basis of CT scan finding (at least one positive radiological parameter of instability) 28 knees were categorized in Group A (potential patellar instability group) and 17 knees in Group B (PFPS).

Results: All patients with 3 or more than three clinical test positive were cases with potential patellofemroal instability except two. Whereas other true patellofemroal pain patients all except 2 were have less than 3 positive clinical tests.

Conclusions: Clinical test have more diagnostic accuracy in evaluating anterior knee pain due to potential patellofemroal instability in comparison to patellofemroal pain without radiological instability.
Instance-Based Ontology Matching For Open and Distance Learning Materials
Authors: Cerón-Figueroa Sergio , López-Yáñez Itzamá , Villuendas-Rey Yenny , Camacho-Nieto Oscar , Aldape-Pérez Mario , Yáñez-Márquez Cornelio
Published: February 2017

The present work describes an original associative model of pattern classification and its application to align different ontologies containing Learning Objects (LOs), which are in turn related to Open and Distance Learning (ODL) educative content. The problem of aligning ontologies is known as Ontology Matching Problem (OMP), whose solution is modeled in this paper as a binary pattern classification problem. The latter problem is then solved through the application of our new proposed associative model. The solution proposed here allows the alignment of two different ontologies —both in the Learning Objects Metadata (LOM) format— into a single ontology of LOs for ODL in LOM format, without redundant objects and with all inherent advantages for handling ODL LOs. The proposed model of pattern classification was validated through experiments, which were done on data taken from the Ontology Alignment Evaluation Initiative (OAEI) 2014 campaign, as well as on data taken from two known educative content repositories: ADRIADNE and MERLOT. The obtained results show a high performance when compared against some of the classifier algorithms present in the state of the art.
Development of alternating current circuit simulation as essential learning support for senior high school student
Authors: Trisniarti Mayang Dwinta , Pujayanto Pujayanto
Published: February 2017

In this study an interactive simulation of Alternating Current circuit was developed by using Articulate Storyline 2 and Adobe Flash CS 6 programs. The aim of this study was providing a computer interactive simulation as essential learning support for Senior High School student. One of the most important features of AC circuit simulation is the easily and continuous material to attain learning objectivity and interest toward students. This AC circuit simulation is built to create real-time sine wave graphs so that student could compare the result if the variable were changed gradually. The validation is held through several experts and reviewers due to get obtained through questionnaires. The results of this research could be concluded that AC circuit simulation for Senior High School Physics have good criteria based on user interface, i.e. 50% of respondents rated enough, 16.67% of respondents rated good, and 33.33% of respondents rated very good. Based on maintenance, i.e. 50% of respondents rated enough, 20% of respondents rated good, and 30% of respondents rated very good. Then based on usability, i.e. 6.67% of respondents rated good and 93.33% rated very good. Furthermore, based on understanding, i.e. 6.67% of respondents rated enough, 30% of respondents rated good, and 73.33% of respondents rated very good. The use of AC circuit simulation could improve the senior high school students’ cognitive ability on the Physics’s course, i.e. with the average score increased from 68.67 to 80.5 based on 30 students.
Preferensi Sumber Informasi Inovasi Pengolahan Kotoran Ternak Menjadi Kompos pada Kelompok Peternak Sapi Potong di Kabupaten Bantul
Authors: Anggriyani Emiliana , Haryadi F Trisakti , Triatmojo Suharjono
Published: February 2017

The aim of this study was to analyze the sources of information of innovation in processing manure into compost. The respondents used in this study were the members of Sido Rejo and Sido Mulyo groups in Bantul who had already obtained information about the innovation of compost. This research was conducted by census through interviews of the object of research to obtain primary data. The preference of the information source of compost innovation was analyzed by descriptive method.
The results of the research showed that most respondents from Sido Rejo and Sido Mulyo group preferred the personal information source. The study came to a conclusion that the personal information source was preferred by most respondents from Sido Rejo and Sido Mulyo groups.

Key words: preference, source of information, innovation, compost
Analisis Kandungan Zat Pengawet Boraks Pada Sampel Jajanan Bakso di Desa Jatipurno Kabupaten Wonogiri
Authors: Swastike Winny , Emawati Shanti , Sari Ayu Intan
Published: February 2017

Wonogiri an area that is well known as an area where people are dominated by traders meatballs. Type meatballs offered vary from meatballs served with noodles in the form of soup or meatballs are sold singly or known as grilled meatballs. Things are very concerned about is the use of borax in meatballs often functioned as chewing of food. Borax poisoning can occur through food, one of which is meatballs as one type of food that is very familiar. This study aimed to analyze the content of borax in food, especially meatballs in Jatipurno village, Wonogiri. This type of research is descriptive laboratory with laboratory tests are qualitative and quantitative methods of flame with acid-base titration method. The population is all hawker meatballs in Jatipurno village, Wonogiri. Sample was taken by purposive sampling of each meatball sellers. The experimental results on samples compound identification borax meatballs with flame method, note that of the 50 samples tested meatballs did not produce a green flame which means not detected borax content in the samples. The final conclusion is that the meatballs were analyzed by flame proving that the sample was circulated in Jatipurno village, Wonogiri is not identified free of borax and borax content. Not to do quantitative research to determine levels of borax meatballs snacks for the qualitative research produces a negative value (does not contain borax).

 

Keywords: Food Additives, meatball snacks, borax
Dietary Energy Utilization in Ongole Grade and Ongole Grade x Limousin Young Bulls Fed Napier Grass and Concentrate
Authors: Rianto E.
Published: February 2017

ABSTRACT
 

            An experiment was carried out to investigate the efficiency of dietary energy utilisation in Ongole Grade (OG) and OG x Limousin (OGL) young bulls under intensive feeding regime. This experiment used 4 OG and 4 OGL young bulls (about 6 months old). The initial body weight of OG was 78±4.69 kg (CV=6.01%), and that of OGL was 91.25±12.62 kg (CV=13.80%). This experiment used “Independent Sample Comparison” method. Parameters observed were energy intake, energy digestibility, energy metabolisability, live weight gain and energy conversion. The results showed that dry matter (DM) intake of  OG PO (26.87 g/ kg BB) was lower (P<0.05) than that of OGL (33.05 g/ kg BB/d); so that energy intake of OG (0.43 MJ/kg BB/d) was also lower (P<0,05) than that of OGL (0.55MJ/kg BB/d). However, were not significant difference (P>0.05) between the two breeds in all other parameters observed. Dietary energy digestibility’s in OG and OGL were 52.60 and 52.20%, respectively. Energy metabolisability’s in OG and OGL were 44.30 and 42.90%, respectively. Live weight gain of were 0.325 and 0.412 kg/d in OG and OGL, respectively Energy conversions in OG and OGL were 46.44 and 55.90 MJ per kilogram live weight gain. It was concluded that OG and OGL young bulls under intensive feeding regime had similar performance in energy utilisation.  

 

Key words: cattle, breed, energy metabolism
Massive Corrections to Entanglement in Minimal E8 Toda Field Theory
Authors: Castro-Alvaredo Olalla
Published: February 2017

In this letter we study the exponentially decaying corrections to
saturation of the second Rényi entropy of one interval of length
\ellℓ
in minimal E_8E8
Toda field theory. It has been known for some time that the entanglement
entropy of a massive quantum field theory in 1+1 dimensions saturates to
a constant value for m_1\ell\gg 1m1ℓ≫1
where m_1m1
is the mass of the lightest particle in the spectrum. Subsequently,
results by Cardy, Castro-Alvaredo and Doyon have shown that there are
exponentially decaying corrections to this behaviour which are
characterized by Bessel functions with arguments proportional to
m_1\ellm1ℓ.
For the von Neumann entropy the leading correction to saturation takes
the precise universal form -\frac{1}{8}K_0(2m_1\ell)−18K0(2m1ℓ)
whereas for the Rényi entropies leading corrections which are
proportional to K_0(m_1\ell)K0(m1ℓ)
are expected. Recent numerical work by Pálmai for the second Rényi
entropy of minimal E_8E8
Toda has identified next-to-leading order corrections which decay as
e^{-2m_1\ell}e−2m1ℓ
rather than the expected e^{-m_1\ell}e−m1ℓ.
In this paper we investigate the origin of this result and show that it
is incorrect. An exact form factor computation of correlators of branch
point twist fields reveals that the leading corrections are proportional
to K_0(m_1 \ell)K0(m1ℓ)
as expected.
Crónicas psicosociales: todos tenemos una historia en común
Authors: Holguín Osorio Henry
Published: February 2017

Las comunidades son complejas, tienen un sistema social de raíz que se hace diferenciable en el seno de una sociedad, en el que se construyen situaciones, características e intereses compartidos por sus miembros. Los actores de estos escenarios sociales desarrollan relaciones y lazos horizontales, se generan los vínculos interpersonales, la cohesión social y los sentidos de pertenencia. Lo que no entiendo, y me crea complejidad de comprensión, es ¿cómo se construyen esas percepciones sociales, esas actitudes, esas creencias y la forma tan enmarañada de interpretar esa realidad?
¿Qué hacer con mis orgasmos?
Authors: Arias Castrillón Juan Camilo
Published: February 2017

Todos los seres humanos atravesamos por una fase en nuestra vida, normalmente en la temprana infancia, en la que nos preguntamos a nosotros mismos: ¿de dónde me viene a mí el placer? ¿Cómo gozo? Y en búsqueda de esa respuesta, los hombres, desafortunados, bajamos la cabeza, fijamos la mirada en nuestra entrepierna y allí encontramos ese apéndice que se levanta orgulloso entre dos bolitas y nos responde la pregunta, nos baja la angustia, que después volverá por el temor a perder ese placer; pero en ese momento simplemente nos entrega la tranquilidad de una pregunta respondida. Las mujeres, por otro lado, fueron más afortunadas. Al bajar la cabeza y mirar entre sus piernas, solo encontró un agujero, un hueco, una nada. Su angustia se disparó inmediatamente, pero la angustia promueve la búsqueda. Y pronto se da a la tarea de encontrar eso con lo que goza, explorando colores, sabores, olores, caricias, etc. Hasta encontrar eso que le satisface.
La responsabilidad del sujeto en asuntos de acoso escolar
Authors: Vergara Medina Cruz Elena
Published: February 2017

Para quienes trabajamos con niños y adolescentes, bien sea en el escenario educativo o en consulta psicológica o psicoanalítica particular, no es raro escuchar que los niños se pelean, discuten, se tratan mal y hasta pasan a los golpes. Tampoco es raro encontrar que muchas veces las familias de estos chicos se comporten de igual manera. Pero lo que si se hace “raro”, no en el sentido de escaso, sino raro en la vía de lo no esperado, es que algunos maestros avalen esta actitud, y más aun, la vivencien entre ellos mismos. Quizás no al extremo de pasar a los golpes, pero si, en la palabra, en los gestos, y en la hostilidad del trato a sus alumnos o a pares.
Renovación sináptica y evolución: el eje de la plasticidad cerebral
Authors: Parra Bolaños Juliana
Published: February 2017

El famoso Psicólogo estadounidense William James, fue el primero en hablar de plasticidad hacia el año de 1890, para describir la modificación de las redes neuronales. Autores como Santiago Ramon y Cajal, Arenander, de Vellis, Clark C. Speidel, entre otros aportaron igualmente al estudio de la sinaptogénesis, su evolución y su renovación; gracias a ellos se ha podido dar cabida y ampliación, a este fenómeno de supervivencia del cerebro. El estudio de la neuroplasticidad constituye uno de los aportes más importantes, que se está dando a la educación en los últimos tiempos. Se trata de una capacidad del cerebro, que le permite aumentar o disminuir el número de ramificaciones neuronales y de sinapsis, a partir del estímulo sobre el córtex cerebral (Acharya, Shukla, Mahajan & Diwan, 2012). Así es como se comprende que la neuroplasticidad sea la base estructural del aprendizaje, porque existe una estrecha relación entre estímulos internos y externos recibidos, y el proceso de transformación del cerebro a lo largo de toda la vida.
Psicología y posconflicto: un acercamiento a la psicología de la paz
Authors: Bonilla Montenegro Daniel Andrés
Published: February 2017

Colombia atraviesa una de las coyunturas más interesantes de los últimos tiempos gracias a los procesos de negociación de la paz. En esta medida, se hace necesario que la psicología identifique su lugar dentro de los procesos de transición hacia la paz. El texto hace una reflexión sobre la importancia de la psicología, en especial de la psicología de la paz, para preparar a los profesionales frente a las demandas de intervención acordes al momento por el que transita el país. Además de esto, se propone la necesidad de orientar los conocimientos psicológicos hacia la coyuntura.
Literatura y cuidado del alma
Authors: Molina Velásquez David Ignacio
Published: February 2017

¿Por qué se considera tan importante el relato para la vida psíquica? ¿Qué implicaciones tiene para el alma el "érase una vez" del cuento de hadas? ¿Cuál es la relación entre el mito tradicional y el así llamado "mito personal? ¿Cómo puede hacerse un uso clínico de estos materiales?
Declaración sobre la medición de la calidad académica de las publicaciones propias de las humanidades
Authors: De Literatura Revista Chilena
Published: February 2017

Declaración sobre la medición de la calidad académica de las publicaciones propias de las humanidades.
Normal y anormal: clínica del trastorno o clínica de lo humano
Authors: Mosquera Jiménez Juan Esteban
Published: February 2017

La delgada línea entre lo subjetivo, la realidad, lo aparente, lo ético; se ve reflejada en los conceptos cambiantes que conciernen lo normal y su antítesis: lo anormal; asunto que toma fuerza dentro de «las psicologías » en función directa de la psicopatología como instrumento ideal del interés capitalista, en tanto se busca en los sujetos una adaptación «condenándolos» a no ser responsables de su goce en muchos casos; más no en todos: se reconoce que la psiquiatría debe intervenir para ayudar cuando la mente se torna incontrolable y es adecuado para la seguridad del sujeto y su entorno; más, en general, una mente crítica, investigativa e inquisitiva, nota que la psiquiatría – para bien o para mal – alimenta con gran potencia la industria farmacéutica como un tentáculo entre muchos del kraken del mundo neoliberal.
Subjetividad y las transformaciones de la temporalidad laboral: contribuciones a la psicología
Authors: Braz de Aquino Cássio Adriano , Nascimento Silva Vanessa , De Sousa Oliveira Thiago , Paiva Martins David
Published: February 2017

El texto tiene carácter teórico y reflexiona sobre las principales evidencias de las transformaciones del trabajo en la contemporaneidad y sus consecuencias sobre la producción subjetiva de los trabajadores. En su construcción el texto privilegia la vinculaciones del tiempo como mediador del orden social y su implicación para la formulación de la subjetividad.
De oralidades, expresiones y vacilaciones: ¿Cómo matar pasiones?
Authors: Rodríguez Bustamante Alexander
Published: February 2017

“Mata pasiones” es una expresión que muy posiblemente todos hemos escuchado o dicho alguna vez, empleada para hacer referencia a algún ser, hombre o mujer, que se deja ver, sentir o escuchar en circunstancias, para nada agradables y mucho menos seductoras. Según el Diccionario de la Real Academia de la Lengua Española, en su vigésima segunda edición, el término “pasión” proviene del latín: passĭo, -ōnis, y este calco del griego. πάθος) y tiene varias acepciones o significados, la primera de las cuales está dada como: Acción de padecer. Escrita con mayúscula inicial, se refiere a la Pasión de Jesucristo. También se define como lo contario a la acción, al estado pasivo del sujeto y a la perturbación o afecto desordenado del ánimo. Para nuestro propósito conviene acogerse al significado siguiente: “Inclinación o preferencia muy vivas de alguien a otra persona”.
Colombia, hacia la construcción de una Psicología Comunitaria
Authors: Ng Henao Daniel Mateo
Published: February 2017

Este ensayo trata sobre los orígenes y la evolución de la psicología comunitaria en Colombia. Inicialmente se hará un recorrido por la época de la colonización española, seguidamente nos ocuparemos del periodo de industrialización, luego se resaltaran sucesos importantes en la historia de nuestro país, como la muerte de Gaitán y el Bogotazo, entre otros eventos históricos.
La violencia en las barras de fútbol. Una aproximación desde la etología y el psicoanálisis
Authors: Uribe Nicolás Ignacio , Castaño Guillermo
Published: February 2017

En pasadas ocasiones hemos dicho que para estudiar los fenómenos de violencia entre los miembros de las barras del futbol en Colombia utilizamos algunos conceptos y teorías de los autores que han abordado los fenómenos de violencia, desde el vasto campo de la Psicología de las masas. Sin embargo, en esta ocasión vamos a retomar conceptos y teorías de la Etología, para articularlos con algunos que hemos tomado de nuestro recorrido por la psicología de las masas, y así establecer correspondencias teóricas (semejanzas pero también diferencias) que permitan triangular datos con la información que hemos obtenido de forma directa  en la investigación de los fenómenos de violencia ya indicados.
Identidades de jóvenes en situación de protección
Authors: Vianchá Pinzón Mildred Alexandra
Published: February 2017

Esta investigación de tipo cualitativo asumió el enfoque comprensivo de la metodología fenomenológica (Creswell, 1998) con el fin comprender la construcción de identidades de 5 jóvenes en situación de protección en la ciudad de Sogamoso-Boyacá. Los relatos de estos jóvenes evidencian la necesidad permanente de buscar en su edad adulta protección en otro tipo de instituciones y dificultad en la consolidación de sus proyectos de vida.
El psicoanálisis es una experiencia de palabra
Authors: Bernal Zuluaga Hernando Alberto
Published: February 2017

Para el psicoanálisis se hace importante tener en cuenta la estructura de la comunicación en el lenguaje y distinguirla del signo natural. Es la misma diferencia que se puede establecer entre la comunicación humana y los códigos en el ámbito de la comunicación animal. Mientras que los elementos de un lenguaje son los «significantes», los elementos de un código son los «índices». El índice es un signo que tiene una relación existencial con el objeto que representa; por ejemplo, el humo es índice del fuego. Para Lacan (1981), índice y significante son opuestos. Lacan concibe el índice como un «signo natural», en el cual hay una correspondencia unívoca fija entre signo y objeto; entre un índice y su referente hay una relación fija, biunívoca, a diferencia del significante, que no tiene ningún vínculo fijo con el significado.