bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacological Strategies for Enzyme Inhibition in Disease Therapeutics:
A Comprehensive Review
Authors: Verma Garima , Bhushan Bharat , Singh Geetanjali , Singh Kuldeep , Kumar Shivendra , Garg Akash , Rajput Pankaj
Published: December 2023

Enzyme inhibition is a crucial pharmacological approach for treating various diseases as it
targets enzymes involved in disease pathogenesis. This review explores the fundamental concepts of
enzyme inhibition, including reversible and irreversible mechanisms, and the various types of enzymes,
such as proteases, kinases, and polymerases, and their contributions to different disease states.
The review discusses the design and production of enzyme inhibitors using methods like structurebased
drug design, high-throughput screening, and rational drug design. The review also discusses
the challenges and successes encountered in discovering and optimizing potent and selective enzyme
inhibitors. Examples of enzyme inhibition's therapeutic benefits include protease inhibitors in
HIV/AIDS therapy, kinase inhibitors in cancer treatment, and acetylcholinesterase inhibitors in Alzheimer's
disease management. The review also examines possible side effects and limits of enzyme
inhibition, focusing on ways to reduce off-target effects and make drugs more specific. At the end of
the review, new trends and future possibilities in enzyme inhibition for treating diseases are talked
about. These include personalized medicine, combination therapies, and new ways to get drugs into the
body. By shedding light on the latest developments, challenges, and future directions, the review aims to
contribute to the advancement of this vital field and revolutionize disease treatment modalities.
The Pattern of Morbidity and Access to Healthcare Service in the Riverine Flood-prone Villages of Assam, India
Authors: Saha Jayanti
Published: December 2023

Background:

Floods are considered one of the common phenomena causing substantial death, morbidity, and damage to infrastructure as well as economic conditions across the world. India receives 75% of its total rainfall in the monsoon season, as a result, annually on average 8 million people are affected by the floods. The Brahmaputra valley of Assam is one of the worst flood-affected regions in the country. This study focuses on understanding the pattern of morbidity, health service utilization, and challenges faced to access healthcare services in the riverine flood-prone villages of Assam.

Methods:

A mixed method study was followed to conduct the study. Primary data have been collected through interview schedules from 83 households. Descriptive statistics of both frequency and percentage were shown for categorical as well as continuous variables. Qualitative data were analyzed using a thematic framework.

Results:

The research findings indicate that in the flood-prone villages people face difficulty in accessing healthcare. However, the challenges intensify during flood times. It was identified that illnesses like fever, skin infection, diarrhea, and dysentery are linked to floods. Three themes were identified from the qualitative analysis i.e., lack of transportation facilities, non-functional sub-centres, and lack of money. The transportation facilities and the non-functional sub-centers were some of the causes along with the financial constraint to avail the health care facilities.

Conclusion:

It can be concluded that to improve the health service condition in the flood-prone areas, there is an urgent need to improve both the quality and quantity of the sub-centres infrastructures and the manpower. Other public health interventions such as providing food, water, and shelter, especially during floods need to be developed. Encouraging early flood preparedness and public health awareness programs through community participation would also help to reduce the damage to these people.
Comprehensive Characterization of Graphene-zinc Oxide-silica
Nanocomposites for Enhanced Conductive Applications
Authors: Kumar Rajesh , Sinha Sanjeet Kumar
Published: December 2023

Background:

The applications of nanocomposite materials require stable and high
electrical performance for the potential conductive applications.

Objectives:

This study aimed to present the effect of introducing different compositions of nanomaterials and to obtain the highly conductive composite composition and its relative analysis.

Methods:

The XRD, SEM, and TEM tests were conducted to study different characteristics
related to the characterization and composition of the nanomaterials.

Results:

The laboratory results show that the conductivity test revealed that Sample-6 (Rk-6)
exhibited the lowest impedance value of 15.26 Ω, indicating its superior conductivity among the
samples tested. These findings significantly contribute to the field of graphene research, providing valuable insights into the potential of GZS nanocomposites for applications that require enhanced conductivity.

Conclusion:

With the proposed composition of the synthesis of GZS nanocomposites using
graphene, zinc oxide, and silica, the study successfully demonstrated improved storage capabilities and can be well suited for low-power applications in the fabrication of nanorods, polymers,
and polyester resin.
Advancement in Opioid Abuse-deterrent Formulation Technologies and Regulatory Expectation
Authors: Patel Jayendrakumar , Patel Rakesh
Published: December 2023

Chronic pain is a byproduct of many diseases and conditions. Along with long-term
opioid medication use in chronic pain management, misuse of this vital medication has been a
topic of much debate over the last two decades. Abuse-deterrent formulations play a critical role
in comprehensive opioid risk management strategies, limiting the attractiveness and drug-liking
qualities of an opioid drug by limiting their bioavailability, making abuse of the tampered opioid
medication less appealing or rewarding, or impeding the extraction of the opioid drug and
thus impeding the administration of the opioid formulation via alternative routes. The present
article covers various regulatory actions, expectations in abuse-deterrent formulation approval,
and emerging opioid abuse-deterrent formulation strategies, such as incorporating physical barriers,
chemical barriers, aversion agents, pH modulating release properties, novel delivery systems,
agonist/antagonist combinations, and prodrugs, as potential approaches to encountering
the crisis of the opioid abuse epidemic. Looking at the severity of the opioid crisis across the
globe now is the right time for various regulatory agencies to come under one roof to save society
from the opioid epidemic, define the policy on how and when to prescribe opioid formulations
to patients, perform abuse risk assessments, and make more efforts to approve only abusedeterrent
opioid medication.
Estimating the Teacher Gap and Funding Requirements for all Education
Levels in Eastern and Southern Africa
Authors: Cummins Matthew
Published: December 2023

Background::

The socioeconomic impacts of COVID-19 added to the learning challenges
across Eastern and Southern Africa (ESA) and significantly increased the resources required
to deliver on basic education goals.

Objective::

This article makes the case for greater budgetary allocations to the education sector
by quantifying the annual funding needs for 20 governments in ESA to achieve different classroom
size targets for all levels of education by 2030.

Methods::

Building on earlier estimation techniques, it develops a teacher costing and affordability
model based on macroeconomic and demographic projections as well as education sector
performance indicators from global databases.

Results::

To meet goals around education and learning, governments in ESA need to pay for
more than five million additional teachers by 2030. When compared to affordability estimates,
which reflect the latest teacher compensation spending trends, the funding shortfall is nearly 50
percent. While there is variation across countries, the compounding shortage of teachers is a
serious risk to improving learning across the region.

Conclusion::

The findings underscore the need to invest more resources in teachers and education
systems more generally. If governments can progressively increase their investment in education
to reach six percent of GDP in 2030, which is in line with the most ambitious target in the
Incheon Declaration, they could recruit an additional three million teachers, which partially
closes the gap. However, to achieve basic learning goals, most governments will need to invest
much more, including up to eight percent of GDP.
Liquid Biopsy: Insights Into Monitoring Tumor Dynamics and Response to Therapy in Patients with Breast Cancer
Authors: Rygiel Katarzyna
Published: December 2023

 The ability to identify the molecular features of metastatic breast cancer
(BC) provides a unique insight into a patient's therapeutic options and the opportunity
to follow the BC progress over time. A classical tissue biopsy remains the standard
procedure to describe tumor biology and guide treatment choices.
However, a liquid biopsy, which can provide medical practitioners with the
opportunity to detect genomic mutations and monitor therapeutic effects, can play a
prominent role in the diagnosis, therapy, and prognosis of patients with different
malignancies, including metastatic BC. In fact, the liquid-biopsy-based therapeutic
interventions led to the approval of alpelisib (a PI3K inhibitor) in patients with
hormone receptor (HR)-positive, human epidermal growth factor receptor2
(HER2)-negative, advanced or metastatic BC, in whom BC had progressed on or
after therapy with an aromatase inhibitor (AI).
This chapter describes a liquid biopsy in BC. It explores its potential for clinical
applications in early diagnosis, monitoring treatment response, detecting minimal
residual lesions, predicting risk of progression or recurrence, and estimating
prognosis. It compares a liquid biopsy with a tissue biopsy, and outlines the benefits
and limitations of each of these procedures, focusing on patients with metastatic BC.
Moreover, this chapter analyses the results from recent studies relevant to liquid
biopsies in BC (e.g., circulating tumor cells (CTCs) and circulating tumor DNA
(ctDNA)).
Teaching the Brain How to Counteract Distress: Practical Lessons About the Stress and Relaxation Responses for Women with Triple-Negative Breast Cancer
Authors: Rygiel Katarzyna
Published: December 2023

In spite of a very difficult situation, women with triple-negative breast
cancer (TNBC) need to realize that some consequences of the cancer-related distress
can be alleviated. Moreover, it is possible to counteract, to some degree, the damaging
effects of this distress. In particular, the relaxation response, as the opposite,
“calming version“ of the “typical” stress response can be achieved by a given patient
with cancer, with some simple, intentional, and conscious efforts.
In fact, modern stress management offers a whole armamentarium of tools and
strategies that are necessary to reduce negative results of stress-related reactions. Since
many warning signs of stress are connected with certain activities of the autonomic
nervous system (ANS), it should be beneficial to patients to learn some basic
information about the ANS functions.
This chapter will explain how to elicit the relaxation response as the “common
denominator” to counterbalance the “typical” stress response. It will also teach how to
use diaphragmatic breathing, and the most feasible to adopt elements of the
mindfulness-based interventions, as well as cognitive-behavioral approaches, to
more effectively combat distress daily.
The Self-kindness Component of Mindfulness Meditation: A Helpful Strategy to Enhance Emotion Regulation and Reduce the Depression and Distress Symptoms in Women with Breast Cancer
Authors: Rygiel Katarzyna
Published: December 2023

It has been demonstrated that one of the components of mindfulness
meditation, called self-kindness, plays a prominent role in alleviating distress
perception, and reducing depressive symptoms, especially among younger women
with breast cancer (BC), who represent a particularly vulnerable patient population,
often struggling not only with a serious illness but also with numerous family and
work-related obligations.
This chapter will describe in detail self-kindness as a technique to help ease distress,
anxiety, and depressive feelings, as well as enhance resilience and establish objective
health-related expectations or goals for patients with cancer, including women with
an aggressive subtype of BC, such as triple-negative breast cancer (TNBC).
The Management of Metastatic Triple-Negative Breast Cancer: An Integrated and Expeditionary Approach
Authors: Rygiel Katarzyna
Published: December 2023

This comprehensive reference is a timely exploration of two vital aspects of triple-negative breast cancer. The book offers a holistic perspective that helps readers to navigate the challenges of managing triple-negative breast cancer (TNBC) with knowledge and confidence.

Understanding Ethnic Disparities and Targeted Therapies: This section provides a critical overview of the ethnic disparities and the latest targeted therapies available for patients facing advanced or metastatic triple-negative breast cancer (TNBC).

Empowering Patients and Enhancing Communication: This section dives into the essential role of patient education, empowerment, effective communication with medical teams, and psychological or supportive approaches, providing invaluable insights into managing advanced or metastatic breast cancer (BC).

Key Features:

Introduces a groundbreaking perspective on the TNBC journey, encouraging patients to view their battle with the disease as an opportunity to leverage modern pharmacological advancements and psychological support for improved outcomes.

Bridges the gap between clinical or research-related aspects of BC management and the personal needs and expectations of patients, promoting a more holistic approach.

Invites perspectives from a wide range of medical professionals, from oncologists and cardiologists to psychologists and nurses, to engage in open dialogues with patients, offering practical education and crucial support.

Provides a wealth of helpful resources (including an appendix) for both patients and their medical caregivers, fostering a comprehensive and supportive approach to managing TNBC.

This book is an informative resource for medical professionals, researchers, and patients, who want to understand the complexities of triple-negative breast cancer and apply current knowledge in their clinical and caregiving practice.
Computational Toxicology Studies of Chemical Compounds Released from Firecrackers
Authors: Lawrence Alfred J. , Tiwari Nikita , Khan Tahmeena
Published: December 2023

Customary firework burning during different festivals and occasions have
been reported from different parts of the world. The pollutants emitted from fireworks
exert toxicological effects on human health and the environment. A virtual study was
performed to assess the extent of binding of sixteen important components of fireworks
including Al2O3
, Ba(NO3
)2
, C6H6
, CO, Ethylbenzene (C8H10) Fe2O3
.H2O, KClO3
, KClO4
,
KNO3
, Na2C2O4, NH3
, NO, o-Xylene (C8H10), SO2
, Sr(NO3
)2
and Toluene (C7H8
) with
human superoxide dismutase (SOD), human serum albumin (HSA), and estrogen
related receptor gamma (ERR-gamma) proteins. AutoDock 4.2.6 was employed to
perform rigid docking. Against HSA, NH3
exhibited the least binding energy i.e. -5.19
kcal/mol. Against ERR-gamma, Al2O3
showed the least binding energy i.e., -4.08
kcal/mol. With SOD, ethylbenzene exhibited binding energy of -4.62 kcal/mol. A
molecular dynamics simulation of 10 ns was performed on the ERR-gamma-o-xylene
complex at 300K at the molecular mechanics level using GROMACS 5.1.2., showing
conformational changes within the protein due to the o-xylene binding. The average
Root Mean Square Fluctuation of the complex was 0.0821 nm. The results can be
further elaborated and may guide future research for the intervention of protein targets
for chemical toxins.
Quality of e-government services at the population and civil registration office Biak Numfor District
Authors: Yamin Muh Nur , Edyanto Edyanto , Haerul Haerul , Tabo Sarfan
Published: December 2023

This study aims to examine the quality of e-government services provided by the Population and Civil Registration Office of Biak Numfor Regency. This research is expected to provide valuable input for local governments and can be used as a basis for improving and optimizing services. This research was conducted at the Population and Civil Registration Office of Biak Numfor Regency. The type of research used in this study is qualitative research with a descriptive approach. Data sources in this study are primary data sources and secondary data sources. The informants in this study were service users from the Population and Civil Registration Office of Biak Numfor Regency. Informants from the Population and Civil Registration Office of Biak Numfor Regency were chosen because they had an important role in the service process. As for community informants, service users are chosen because they have information that is about the research topic and can provide more accurate ones. The selection of informants is carried out through purposive sampling techniques.
Barth on ‘Preaching Toward Truth’
Authors: Laubscher Martin
Published: December 2023

Karl Barth’s doctrine on “Jesus Christ, the True Witness,” in Church Dogmatics IV/3, is an extremely rich and complex text which – strangely enough – still awaits proper reception within both systematic theology and homiletics. Therefore, this paper introduces Barth anew to us, and then in essence explores this well-kept secret in Barth’s oeuvre. In doing so, it provides a few important keywords which may reveal some deeper truth(s) in Barth’s doctrine of reconciliation and the question of preaching toward truth.
Distributed Data Proceeding Systems Architectures Resource Efficiency Improvement on the Basis of Apriory Data about the Jobs Late Completion Times
Authors: Klimenko A. B.
Published: December 2023

Purpose of research. The purpose of this study is to develop a method for improving the efficiency of distributed architectures of data processing systems operating in the fog and edge layers of the network. In conditions of high dynamics of both the network infrastructure and the load, the task of forming the architecture of data processing systems is solved regularly (migration of virtual machines, horizontal scalingб etc.) At the same time, the issue of the consumption of the residual resource of computing nodes is practically not considered, while the often used devices have relatively low capacity, and their high workload leads to a reduction in the service life. Therefore, the creation of methods for forming an architecture of a computing device system that is effective in terms of saving a computing resource is an urgent task.

Methods. The main scientific methods used in this study are domain analysis, operations research methods, optimization methods and computer modeling, confirming the feasibility of the main aspects of the developed method. To improve the efficiency of placing computational tasks on the nodes of a network fragment, this paper formulated a multicriteria optimization problem, where each element of the vector objective function corresponds to an individual value of the probability of failure-free operation of a computing device. To obtain estimated values of the cost function, a priori estimates of the late completion of the solution of computational problems by nodes are used, since the resource allocated for solving depends on the allocated time, and the time for solving the problem, respectively, on the allocated computing resource. The value of the cost function is calculated on the basis of approximate a priori estimates, which leads to a positive effect in terms of the consumption of computing resources of devices.

Results. The result of the study is a developed method for improving the efficiency of distributed architectures of data processing systems operating in the fog and edge layers of the network.

Conclusion. The method proposed in this work allows to choose such a load distribution in order to reduce the workload of devices and thus reduce the consumption of computing resources of the devices.
Effectiveness of a Continuous Remote Temperature Monitoring Program to Reduce Foot Ulcers and Amputations: Multicenter Postmarket Registry Study
Authors: Shih Chia-Ding , Scholten Henk Jan , Ripp Gavin , Srikanth Kirthana , Smith Caileigh , Ma Ran , Fu Jie , Reyzelman Alexander M
Published: December 2023

Background

Neuropathic foot ulcers are the leading cause of nontraumatic foot amputations, particularly among patients with diabetes. Traditional methods of monitoring and managing these patients are periodic in-person clinic visits, which are passive and may be insufficient for preventing neuropathic foot ulcers and amputations. Continuous remote temperature monitoring has the potential to capture the critical period before the foot ulcers develop and to improve outcomes by providing real-time data and early interventions. For the first time, the effectiveness of such a strategy to prevent neuropathic foot ulcers and related complications among high-risk patients in a real-world commercial setting is reported.

Objective

This study aims to evaluate the effectiveness of a real-world continuous remote temperature monitoring program in preventing neuropathic foot ulcers and amputations in patients with diabetes.

Methods

In this retrospective analysis of a real-world continuous remote temperature monitoring program, 115 high-risk patients identified by clinical providers from 15 geographically diverse private podiatry offices were analyzed. Patients received continuous remote monitoring socks as part of the program. The enrollment was based on medical necessity as decided by their managing physician. We evaluated data from up to 2 years before enrollment and up to 3 years during the program. The primary outcome was the rate of wound development. Secondary outcomes included amputation rate, the severity of the foot ulcers, and the number of visits to an outpatient podiatry clinic after enrolling in the program.

Results

We observed significantly lower rates of foot ulceration (relative risk reduction [RRR] 0.68; 95% CI 0.52-0.79; number needed to treat [NNT] 5.0; P<.001), less moderate to severe ulcers (RRR 0.86; 95% CI 0.70-0.93; NNT 16.2; P<.001), less amputations (RRR 0.83; 95% CI 0.39-0.95; NNT 41.7; P=.006), and less hospitalizations (RRR 0.63; 95% CI 0.33-0.80; NNT 5.7; P<.002). We found a decrease in outpatient podiatry office visits during the program (RRR 0.31; 95% CI 0.24-0.37; NNT 0.46; P<.001).

Conclusions

Our findings suggested that a real-world continuous remote temperature monitoring program was an effective strategy to prevent foot ulcer development and nontraumatic foot amputation among high-risk patients.
Antioxidant and Antiaging Potential of Salak Fruit Extract (Salacca zalacca (Gaert.)Voss)
Authors: Widowati Wahyu , Dani Dani , Vera Vera , Yuninda Viranda Andria
Published: December 2023

Natural skin aging is indicated by a loss of skin structure and integrity caused by external factors including UV exposure. This exposure causes oxidative stress on skin cells, initiates aging, and degradation of extracellular matrix (ECM) structure which is composed of many proteins, including collagen and elastin. ECM degradation is caused by the increased activity of proteolytic enzymes, one of which is elastase (closely related to wrinkling). To inhibit oxidative stress during the photoaging process, the skin needs antioxidant compounds. Salak (Salacca zalacca (Gaert.)Voss) is a fruit that is rich in antioxidants because it contains flavonoid, phenolic, and polyphenolic compounds, including chlorogenic acid. The purpose of this study is to demonstrate the antioxidant activity and antiaging properties of salak fruit extract (SFE) as a candidate for active ingredients in the prevention of aging. To determine the antioxidant activity of SFE, 2,2-diphenyl-1-picrylhydrazil (DPPH) scavenging and ferric reducing antioxidant power (FRAP) assays were performed, while elastase assays were performed to determine the anti-aging properties of SFE. The IC50 values for DPPH scavenging and FRAP activity of SFE were 107.52 μg/mL and 16.82 μg/mL with the highest activity at 68.79% and 97.96%, at concentrations of 200 and 50 μg/mL, respectively. Meanwhile, the anti-aging properties determined through the elastase assay showed an IC50 value of 19.71 μg/mL with the highest inhibition 72.50% at a concentration of 66.67 μg/mL. SFE has the potential as an active ingredient in preventing aging through its antioxidant activity and anti-aging properties.
Kompetisi dan Posisi Tubuh Perempuan dalam Iklan Rokok: Analisis Wacana Kritis Pada Novel “Gadis Kretek” Karya Ratih Kumala
Authors: Indriani Laillia Dhiah
Published: December 2023

Using women's bodies in product marketing advertisements is nothing new. The female body is deliberately presented as a marketing strategy. In practice, it is not uncommon for women to be categorized into three trinities, namely, girl, wife, and entertainer. What's worse, this is justified and reproduced by various media. The Gadis Kretek novel is a literary work that juxtaposes the female body with cigarette advertisements. This research was conducted to uncover how women's bodies are selected, used, and displayed for marketing activities of cigarette products that are attached to men by society and become a symbol of masculinity. The method that will be used as a data analysis tool is Norman Fairclough's critical discourse analysis, which focuses on aspects of linguistic practice, discursive practice, and social practice. The results of this study indicate that in product promotion, the female body is used as a desire production machine that will attract potential buyers. Women in ad frames are also categorized based on the Girl-Wife-Entertainer trinity, where the three of them have their own identities but are still presented as complements to men. From this research, it can be seen that literary works also commodify discourses on beauty and the female body. The female body seems to be an affirmation of the construction of masculinity.
Effectiveness of Nurse-led Educational Interventions on Glycemic Control and Self-care Behaviors of Type 2 Diabetics: A Systematic Review
Authors: Shi Yi , Liang Xueqing
Published: December 2023

Background: Blood glucose control is challenging for patients with diabetes and is often associated with self-care behaviors. The effectiveness of nurse-led educational interventions for glycemic control and self-care behaviors in patients with type 2 diabetes is unclear.Objective: To determine effectiveness of nurse-led educational intervention on glycemic control and self-care behaviors in patients with type 2 diabetes.Design: Mixed methods systematic review.Data Sources: A comprehensive search in Medline, CINAHL and Scopus was conducted in February 2023 to identify peer-reviewed papers published between 2003 and 2023.Review Methods: The review was guided by the Joanna Briggs Institute systematic review manual. Data were extracted and assessed by two evaluators using a standardized checklist. Due to the high level of heterogeneity between studies, the data were analyzed using Popay et al.'s (2006) conduct of narrative synthesis in systematic reviews.Results: Ten randomized controlled trials met the inclusion criteria. Studies described nurse-led educational interventions delivered either face-to-face or online. The outcomes of the educational interventions and the measurement tools used were diverse, with many studies reporting attrition. Most studies reported that nurse-led educational interventions improved outcomes for patients with type 2 diabetes.Conclusions: The evidence identifies that nurse-led educational interventions are effective for glycemic control and self-care behaviors in patients with type 2 diabetes. This review demonstrates evidence of approaches that could inform future practice and research to support all adult populations of patients with type 2 diabetes to improve glucose control and self-care behaviors. Future research would benefit from well-designed clinical trials that use common outcome measures to provide more information about the effectiveness as well as the sustainability of such interventions.
MOTHERS KNOWLEDGE TOWARDS WOUND CARE IN THE GREATER BANDUNG AREA
Authors: OKTAVIANI DEDE JIHAN , ZUHROTUN ADE , BARKAH CECEP SAFA'ATUL
Published: December 2023

Objective: Proper wound care is essential to prevent complications and worsening of the injured patient. Everyone in the family needs to possess wound care knowledge, especially the mother, who plays a role in making decisions about health care and family health behaviors. This study aims to evaluate mothers' knowledge towards wound care in the Greater Bandung Area.

Methods: This cross-sectional study involved 100 participants with varied backgrounds and had met the inclusion criteria. The study was conducted using questionnaires distributed online to the mother community living in the Greater Bandung Area, West Java, then data processing and analysis were carried out.

Results: The results showed that mothers in the Greater Bandung Area had a good level of knowledge (27%), average (52%), and less (21%). In addition, plasters with wound care solutions were still the mothers' main choice in wound care. Nevertheless, there are many choices of pharmaceutical dosage forms for wound care that have been developed today to optimize the wound healing process.

Conclusion: Most of the mothers already have an average level of knowledge to good. However, there are still quite a lot of mothers who have a lack of knowledge related to wound care. Therefore, educational programs must be developed to raise awareness about wound care and management, as well as knowledge about pharmaceutical dosage forms for wound care.
FORMULATION AND EVALUATION OF HAND AND BODY LOTION FROM PURPLE SWEET POTATO (IPOMOEA BATATAS L.) PEEL EXTRACT AND ITS ANTIOXIDANT ACTIVITY
Authors: NARSA ANGGA CIPTA , FRIDAYANTI ADITYA , GAMA SABANIAH INDJAR , MUTA’ALI MUHAIMIN , WATHONI NASRUL
Published: December 2023

Objective: This study aims to investigate the antioxidant activity of purple sweet potato (Ipomoea batatas L.) peel extract. The goal is to determine the levels of antioxidant activity in hand and body lotion formulas that use purple sweet potato peel extract as an antioxidant agent and to evaluate the formulas to identify the one with the best physical stability.

Methods: The antioxidant activity was assessed using the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical inhibition method. Physical stability of the hand and body lotion formula was evaluated within 4 w storage at room temperature, the evaluation was based on measurements of various lotion characteristics such as organoleptic properties, pH, homogeneity, viscosity, phase separation, and spreadability.

Results: The results of this study showed that the purple sweet potato peel extract exhibited antioxidant activity, with an IC50 value of 44.582±1.19 ppm. The antioxidant activity of the hand and body lotion formulas had IC50 values of 83.319±1.01, 63.181±0.97, and 24.107±0.63 ppm for formulas containing 1,3, and 5% extracts, respectively. The hand and body lotion formula containing 3% extract demonstrated the best physical stability, as it remained physically stable after being stored at room temperature for 4 w.

Conclusion: The extract of purple sweet potato peel presented very strong antioxidant activity and has great potential for use in hand and body lotion formulas as an antioxidant agent.
Text Generation: Using Markov Model & LSTM Networks to Generate Realistic Text
Authors: Chary Podakanti Satyajith
Published: December 2023

Abstract: Text generation plays a crucial role in various natural language processing applications, ranging from creative writing to chatbots. This research delves into the realm of text generation by exploring and comparing two distinct techniques: Markov models and Long Short-Term Memory (LSTM) networks. The study focuses on their ability to generate realistic text within specific styles or genres, providing valuable insights into their respective strengths and limitations. Markov models, rooted in probability theory, and LSTM networks, a type of recurrent neural network, represent contrasting approaches to text generation. The research employs these techniques on a carefully curated dataset, evaluating their performance based on coherence, style, and contextual relevance. The comparison aims to elucidate the nuanced differences in how these models capture dependencies within the data and their effectiveness in simulating authentic linguistic patterns. Through rigorous experimentation, this research investigates the intricacies of both Markov models and LSTM networks, shedding light on their individual contributions to the task of text generation. The examination extends beyond mere algorithmic efficacy, considering the impact of these techniques on the quality and diversity of the generated text. Additionally, the study explores the influence of hyperparameters, such as temperature in the context of LSTM networks, on the output's richness and variability.
Rainfall Intensity Variations at Different Metrological Stations of Kashmir Valley
Authors: Pandit Dr. Bashir Ahmad
Published: December 2023

Abstract: Rainfall being an important source of water and natural source of recharge for ground water, lakes and rivers etc., its variation forms an important subject of Study. The variation of rainfall has a direct influence on the output of agriculture, occurrence of floods and design of hydraulic structures. Earlier the variation of rainfall could not be studied with precision but the developments in the metrology science have, however, rendered the study possible and precise. The present work study involves study of temporal and spatial variation of monthly seasonal and annual rainfall data of six stations of Kashmir valley for the period 1991 to 2020, which has been used for the determination of various rainfall-time graphs. The rainfall time curves been further used to determine the trend of pattern in temporal and spatial variation and precipitation forecasting and to determine the periods of maximum and minimum rainfall and also stations of maximum and minimum rainfall. The study also involves frequency analysis of rainfall data which forms the basis for flood forecasting and design of hydraulic structures.
Survei Jentik Nyamuk Aedes aegypti Di Wilayah Kerja Puskesmas Pasirkaliki, Kecamatan Cimahi Utara
Authors: Nany Djuhriah  , Neneng Yetty Hanurawati  , Mimin Karmini  , Sadono Setioko
Published: December 2023

Background: Hemorrhagic fever disebabkan oleh virus dengue yang ditularkan melalui gigitan nyamuk Aedes aegypi. Penyakit ini meningkat setiap tahunnya dan dapat menyerang semua kelompok umur. Tujuan pengabdian ini adalah mengukur kepadatan jentik di wilayah RW 03 Desa Pasirkaliki Kecamatan Cimahi Utara. Metode: Mitra dalam kegiatan ini adalah RW 01 yang meliputi RT:01, RT 02, RT 04 dengan metode survei dan observasi. Hasil: RT 01: House Index: 44,4 %, Container Index 24,6%, RT 02: House Index 22,2 %, Container Index: 18,4 %, RT 04: House Index 14,4 %, Container Index 29,7 %, RT 05: House Index: 22,7 %, Container Index: 2,5 %. Density Figure 6 dengan nilai 69,4%. Kesimpulan: Breteau Index (BI) RW 03 dengan Density Figure (DF) 6, karena memiliki nilai 69,4% termasuk dalam kategori tinggi.
Pelatihan Komputer bagi Guru-Guru Anak Usia Dini di PAUD Kasih Ibu
Authors: Angkur Maria Fatima Mardina , Maria D.V. Bangggur  , Beta Palmin
Published: December 2023

Background: Persoalan yang ditemukan pada Mitra adalah yang berkaitan dengan kemampuan guru dalam menggunakan komputer masih rendah. Hal ini terjadipada guru-guru di PAUD Kasih Ibu yang memiliki jumlah guru sebanyak 4 orang guru.Untuk meningkatkan kemampuan guru dalam menggunakan computer. Metode: Metode pelaksanaan kegiatan pelatihan ini dilaksanakan dalam empat tahap yaitu tahap perencanaan dimana tim pelaksana melakukan komunikasi bersama pihak sekolah terkait dengan jadwal pelaksanaan kegiatan serta tim PkM juga mempersiapkan segala hal yang dibutukan seperti modul dan materi untuk dipresentasikan. Tahap kedua adalah pelaksanaandimana tim PkM melaksanakan kegiatan bersama dengan guru-guru PAUD serta tahap yang ketiga adalah tahap evaluasi dimana tim PkM melakukan evaluasi terkait hasil dari kegiatan pelatihan. Evaluasi diberikan dengan tim PkM mengajukan pertanyaan kepada guru-guru. Hasil: Kegiatan pengabdian kepada masyarakat ini dilaksanakan selama satu hari yakni pada tanggal 25 Februari 2023. Berdasarkan hasil diskusi bersama dengan guru-guru anak usia dini di PAUD Kasih Ibu maka diputuskan bahwa kegiatan pelatihan difokuskan pada pelatihan membuat tabel. Hal ini dikarenakan guru-guru masih mengalami kesulitan dalam membuat tabel kususnya yang berkaitan dengan penyusunan perangkat pembelajaran. Kesimpulan:Dari hasil evaluasi diperoleh data bahwa guru-guru PAUD Kasih Ibu telah memahami alur pembuatan tabel dengan baik
Faktor-faktor yang Memengaruhi Kelelahan Kerja di Line Painting PT X Jakarta
Authors: Mirza Kirana Maulidya  , Farhana Syahrotun Nisa Suratna  , Yeremia Rante Ada'
Published: December 2023

Background: Kelelahan menjadi penyakit pembunuh nomor dua setelah penyakit jantumg. Survei disebuah negara maju menyatakan setiap harinya terdapat 10-15% penduduknya yang mengalami kelelahan saat bekerja. Kelelahan kerja menjadi salah satu persoalan krusial yang perlu ditanggulangi karena dapat menyebabkan kondisi kesehatan menurun sehingga dapat memicu kecelakaan kerja, dan produktivitas serta prestasi kerja menurun. Penelitian ini bertujuan untuk melihat faktor-faktor yang memengaruhi kelelahan kerja. Metode: Penelitian dilakukan di PT X Jakarta menggunakan metode cross-sectional dengan populasi 60 pekerja pada line painting. Teknik sampling yang digunakan adalah total sampling, sehingga seluruh populasi menjadi sample. Hasil: Uji korelasi dilakukan menggunakan rank spearman dengan hasil sebagai berikut: 1) usia dengan kelelahan kerja p value = 0,000 (p < 0,05) dan r = 0,825; 2) masa kerja dengan kelelahan kerja p value = 0,000 (p < 0,05) dan r = 0,843; 3) shift kerja dengan kelelahan kerja p value = 0,007 (p < 0,05) dan r = 304; 4) status gizi dengan kelelahan kerja p value = 0,000 (p < 0,05) dan r = 0,449. Selanjutnya uji regresi logistic ordinal menyatakan bahwa usia, masa kerja, shift kerja, dan status gizi secara bersama-sama memberikan kontribusi sebesar 29,3% terhadap kelelahan kerja. usia menjadi variabel yang paling berpengaruh terhadap terjadinya kelelahan kerja dengan p value = 0,003 (p < 0,05) dan nilai OR sebesar 7,72. Kesimpulan: Terdapat hubungan antara usia, masa kerja, shift kerja, dan status gizi dengan kelelahan kerja. Faktor yang paling berpengaruh terhadap terjadinya kelelahan kerja adalah usia.
Sosialisasi Penerapan Kepemimpinan Situasional Berbudaya Organisasi untuk Meningkatkan Kinerja Perawat
Authors: Heryyanoor Heryyanoor , Restu Pertiwi Melinda , Hardiyanti Diana
Published: December 2023

Latar Belakang: kesalahan penerapan gaya kepemimpinan bagi manajer keperawatan berdampak pada kinerja dan produktivitas kerja perawat. Dampak lain juga mempengaruhi kepuasan dan loyalitas pelanggan serta kualitas pelayanan kesehatan. Tujuan dari kegiatan pengabdian masyarakat ini adalah mensosialisasikan penerapan gaya kepemimpinan situasional berbudaya organisasi untuk meningkatkan kinerja perawat di rumah sakit. Metode: Kegiatan utama yang dilakukan adalah penyampaian materi sosialisasi yang dilanjutkan dengan kegiatan FGD (Focus Group Discussion) yang dilakukan di awal dan akhir kegiatan dengan menggunakan formulir diskusi situasi kondisi staf sebagai bahan evaluasi dengan 8 pernyataan kepada 18 manajer keperawatan. Hasil: Terdapat perubahan sikap dan kesamaan persepsi responden tentang penerapan gaya kepemimpinan situasional berbudaya organisasi untuk meningkatkan kinerja perawat sebelum dan sesudah dilakukan sosialisasi. Kesimpulan: kegiatan sosialisasi dapat diterima, diapresiasi, dan dapat diterapkan oleh pengelola keperawatan sebagai upaya peningkatan kinerja perawat di rumah sakit dengan pedoman penelitian dan modul pembelajaran yang telah disampaikan.
Pelatihan Guru SD Dalam Pembelajaran STEM Menggunakan IoT Berbasis Canva
Authors: Fida Rahmantika Hadi  , Liya Atika Anggrasari  , Endang Sri Maruti
Published: December 2023

Background: Pelatihan guru dalam Program Pendampingan Pembelajaran STEM menggunakan IoT berbasis Canva merupakan inisiatif yang inovatif untuk memberikan guru alat yang efektif dalam merancang dan menyajikan materi pembelajaran yang menarik, visual, dan mudah dipahami. Dengan demikian, guru akan mampu menghasilkan materi pembelajaran yang dapat merangsang minat dan partisipasi siswa dalam bidang STEM melalui pengalaman praktis dan visual yang mengesankan. Metode: Metode pelaksanaan pada pelatihan ini yaitu koodinasi dengan guru menegenai program pelaksanaan pendampingan program dan evaluasi. Penelitian dilakukan pada guru-guru di SDN 01 Kanigoro Madiun. Hasil: Hasil pelatihan ini menunjukkan bahwa program ini memberikan guru pengetahuan dan keterampilan yang diperlukan untuk mengintegrasikan konsep STEM dan IoT ke dalam desain pembelajaran yang kreatif dan menarik menggunakan platform Canva. Kesimpulan: Integrasi pembelajaran STEM menggunakan IoT berbasis Canva memberikan cara baru yang efektif dan menarik dalam mengajarkan konsep-konsep STEM kepada siswa.
Developing Effective Procedures for Public Participation in Spatial Planning Regulation in Indonesia: Lesson Learned from Australia
Authors: Widiatedja I Gusti , Ranawijaya Ida , Purwani Sagung , Atmaja Bima
Published: December 2023

Public participation is a crucial aspect of spatial planning, serving to achieve sustainable development objectives. The Indonesian government has recognized this fact andincorporated public participation in its spatial planning lawsand regulations. However, procedures for involving the public have been criticized for lacking genuine participation, highlighting opportunities for public input only being offeredformally. Meanwhile, public participation is considered a significant component of spatial planning regulation in Australia, particularly in Victoria. The government has involved the public in various stages of the planning process, including creating a planning scheme, issuing planning permits, and completing planning agreements. Based on the established procedures under current Australian legislation, this study aims to provide a practical solution by examining and contrasting the role of public participation in spatial planning regulation between Indonesia and Australia. This study concluded that Indonesia might consider adopting Australia's strategy and setting up planning panels to regulate spatial planning. Planning agreements can also be advantageous, particularly for large-scale or mega projects that significantly negatively impact the environment and local communities.
All-on-4 Konseptinde Altyapı ve Bruksizmin Biyomekanik Etkisi: Sonlu Elemanlar Analizi
Authors: SEZER Taygun , KILIÇ Kerem , ESİM Emir
Published: December 2023

Bu çalışma, iki farklı yükleme kuvveti altında farklı protetik altyapılara sahip maksiller all-on-4 konseptlerindeki stres dağılımını sonlu elemanlar analizi kullanarak incelemeyi amaçlamıştır. Krom-kobalt, polietereterketon, titanyum ve zirkonya olmak üzere 4 farklı protetik altyapı materyali ile all-on-4 modeller tasarlandı (Sırasıyla model 1, model 2, model 3, model 4). Sağlıklı ve bruksist bireylerin ısırma kuvvetlerini temsil eden iki farklı yükleme koşulu altında kemik doku, implant elemanları ve protetik elemanlar üzerindeki stresler değerlendirildi. Peri-implant kemik, implant elemanları ve kronlar üzerindeki stresler model 2>model 3>model4>model 1 olarak sıralandı. Bruksist yükleme altında tüm modellerdeki ve sağlıklı yükleme altında model 2' deki kortikal kemikte oluşan baskı stresleri aşırı yükleme sınırını aştı. Kortikal kemikte oluşan gerilme stresi ve dayanaklardaki von Mises stres bruksist yükleme altındaki model 3’ te aşırı yükleme sınırını aştı. Model 2’ de, her iki yükleme koşulunda kortikal kemikte oluşan gerilme stresi ve bruksist yükleme altında implantlar, dayanaklar ve kronlardaki von Mises stresler aşırı yükleme sınırını aştı. Altyapılardaki stresler model 2>model 1>model 4>model 3 olarak sıralandı. Bruksist bireylerde all-on-4 konsepti planlanırken bu çalışmadaki kortikal kemikte oluşan aşırı yüklemeler göz önünde bulundurulmalıdır. PEEK altyapı kemik doku ve çevreleyen yapılar üzerinde polimerik olmayan altyapılara göre daha fazla stres oluşturduğundan polimerik olmayan altyapılar all-on-4 konsepti için daha uygun olabilir
Generalization despite overfitting in quantum machine learning models
Authors: Peters Evan , Schuld Maria
Published: December 2023

The widespread success of deep neural networks has revealed a surprise in classical machine learning: very complex models often generalize well while simultaneously overfitting training data. This phenomenon of benign overfitting has been studied for a variety of classical models with the goal of better understanding the mechanisms behind deep learning. Characterizing the phenomenon in the context of quantum machine learning might similarly improve our understanding of the relationship between overfitting, overparameterization, and generalization. In this work, we provide a characterization of benign overfitting in quantum models. To do this, we derive the behavior of a classical interpolating Fourier features models for regression on noisy signals, and show how a class of quantum models exhibits analogous features, thereby linking the structure of quantum circuits (such as data-encoding and state preparation operations) to overparameterization and overfitting in quantum models. We intuitively explain these features according to the ability of the quantum model to interpolate noisy data with locally "spiky" behavior and provide a concrete demonstration example of benign overfitting.
Zur Darstellung der Phraseologie im russisch-deutschen phraseologischen Lexikon
Authors: Eckert Rainer
Published: December 2023

Der vorliegende Artikel befasst sich mit der historischen Phraseologie des Russischen im Russisch-deutschen und deutsch-russischen Wörterbuch (1774–1779) von Christoph Schmidt. Es wird aufgezeigt, dass die Phraseologie bereits vor 200 Jahren relevanter Bestandteil bei der Erstellung eines zweisprachigen Wörterbuches war und sich mit Problemen wie phraseologischer Varianz oder auch der Rektion phraseologischer Wendungen auseinandergesetzt wurde. Abschließend geht der Artikel die Entwicklung der Phraseologie als linguistische Teildisziplin ein und beschreibt die Entwicklungen innerhalb der Russistik an der Universität Leipzig.
Ieskats priedēkļverbos Kristofa Fīrekera vārdnīcā
Authors: Frīdenberga Anna
Published: December 2023

Rakstā aplūkoti priedēkļverbi Kristofa Fīrekera latviešu-vācu vārdnīcā. Kopumā abos vārdnīcas manuskriptos ir apmēram 100 verbi, kuriem ir doti vairāki prefiksālie atvasinājumi. Vārdnīcā lietoti visi latviešu valodas verbu prefiksācijā izmantojamie 11 priedēkļi, kā arī tiem līdzīgais komponents caur. Redzamas ievērojamas atšķirības vārdnīcas norakstos – 2. manuskripts atšķiras gan ar to, ka bieži pie verba ir piezīme, ka tam raksturīgi saliktie verbi (proti, priedēkļverbi), gan ar priedēkļverbu vai priedēkļu biežo uzskaitījumu. Atšķirības starp manuskriptiem ir lielākas, nekā līdz šim domāts. Lielāka uzmanība priedēkļverbiem pievērsta vārdnīcas otrajā norakstā, kur verbi papildināti ar tiem priedēkļiem, kuri 1. manuskriptā nav minēti, dažkārt pat it kā cenšoties aizpildīt visu attiecīgo priedēkļverbu vārddarināšanas ligzdu. Katram priedēklim ir kāda tipiskākā nozīme, kas parādās biežāk, un arī gadījumos, kad vārdnīcā minēts priedēkļu uzskaitījums, izmantotas šīs, domājams, tipiskākās, nozīmes. Lai gan priedēkļverbiem var konstatēt raksturīgas nozīmju grupas, tomēr katrs gadījums ir aplūkojams individuāli.