bluuebunny/crossref_metadata_2025 huggingface dataset:
Adaptive Methods for Revenue Model learning of a Slice Broker in the Presence of Adversaries
Authors: Khan Md Muhidul Islam , Nencioni Gianfranco
Published: May 2023

In the Fifth Generation (5G) of mobile networks, Multi-Access Edge Computing (MEC) refers to the deployment of computing resources closer to the end-users for improved service delivery. In the context of 5G MEC, the slice broker plays a crucial role in managing the allocation of resources among the different network slices, which are logical networks on top of a shared infrastructure. The slice broker is a business entity that acts as an intermediary between the slice tenants and the infrastructure provider and is responsible for allocating resources (such as CPU, memory, and network bandwidth) required to set up the network. The slice broker must ensure that resources are allocated in a way that the revenue is maximized. In a dynamic environment, the slice broker must learn the revenue model adaptively and online. Adversaries can significantly reduce the revenue by misleading the system about the resources pretending to be selfish nodes or creating noise. The slice broker should learn the revenue model in the presence of adversaries. We apply cooperative deep reinforcement learning with consensus mechanism and consensus deep learning to learn the revenue model adaptively. We also compare our proposed methods with the reference solution. Simulation results show that our proposed methods, especially the cooperative version, outperform the reference solution.
Tissue-location specific transcription programs drive tumor initiation dependencies in colon cancer
Authors: Easwaran Hariharan , Yang Lijing , Tu Lei , Petkovich Daniel , Thursby Sara-Jayne , Bisht Shilpa , Mao Yiqing , Gabrielson Kathy , Yen Ray-Whay Chiu , Largent Tina , Brock Malcolm , Zahnow Cynthia , Baylin Stephen
Published: May 2023

It is unknown why cancers of the same tissue-type but in anatomically distinct locations exhibit different molecular dependencies for tumorigenesis. Proximal and distal colon cancers (CC) exemplify such characteristics, with BRAFV600E predominantly occurring in proximal CC along with increased DNA methylation phenotype. Using mouse colon organoids, we show that proximal and distal colon stem cells have distinct transcriptional programs regulating stemness and differentiation. The homeobox transcription factor, Cdx2, frequently silenced by DNA methylation in proximal colon cancers, was identified as a key mediator of the differential transcriptional programs. Cdx2-mediated proximal colon-specific transcriptional program is concurrently tumor suppressive, and its loss is critical for BRAFV600E-driven transformation of proximal colon stem cells. Human proximal CC with CDX2-downregulation showed similar transcriptional program as the mouse proximal organoids with Cdx2 loss. Our results suggest a model in which developmental transcription factors maintain tissue-location specific transcriptional programs that create tissue-type origin specific dependencies for tumor initiation.
Primordial and 244Pu-derived xenon missing from Earth's convecting mantle
Authors: Bekaert D.V. , Caracausi A. , Byrne D. J. , Caro G. , Broadley M.W. , Barry P.H. , Marty B. , Seltzer A.M.
Published: May 2023

Mantle-derived noble gases are exceptional recorders of the history of planetary volatile elements (C, N, water), which are key to the development of life on Earth1,2. For example, the relative proportions of 129Xe derived from radioactive-decay of extinct 129I and 136Xe from fission of extinct 244Pu as well as extant 238U provide crucial timestamps for mantle volatile loss and for the formation of a habitable surface environment3,4,5. However, the low abundance of heavy noble gases (Ar, Kr, Xe) in mantle-derived samples constitutes a major analytical challenge that has thus far precluded a comprehensive understanding of mantle volatile evolution6,7. Here, we employ dynamic mass spectrometry8,9 to measure convecting mantle-derived Ar-Kr-Xe isotopes in Mt. Etna (Sicily) and Eifel (Germany) volcanic gases at ultra-high precision. Our data reveal that the fractions of (i) total fissiogenic 136Xe from 244Pu-Xe (denoted 136XePu/136XeTF) and (ii) stable Kr and Xe from primordial (i.e., accretionary) sources are both significantly lower than previous estimates suggest. The latter point requires pervasive and almost complete overprinting by subduction-derived surface components. The large 129Xe excess from 129I decay implies that the lack of XePu cannot be ascribed to an extensive loss of short-lived radionuclide products via mantle degassing. Instead, missing XePu may require (i) a reevaluation of the initial (chondritic) Pu/U within Earth10 or (ii) significant fractionation of Pu/U during early Earth processes, both of which would have far-reaching implications for modeling of terrestrial Xe evolution11. Notably, quantitative incompatible element extraction to the Hadean crust and subsequent reintroduction of 238U via subduction (after 244Pu had become extinct, i.e., after ~ 500 Myr) could have contributed to lowering the ultimate 136XePu/136XeTF of the depleted upper mantle. This indicates that subduction quantitatively overprinted the compositions of both volatile (e.g., noble gases) and refractory (e.g., uranium) elements within Earth's mantle.
Evolution Characteristics and Its Driving factors of Production–Living–Ecological Space in typical hilly areas: A Case Study of Changshou District in China from 2000 to 2020
Authors: yang wen , Li Wei , Li Bin
Published: May 2023

In the context of sustainable territorial spatial development, the ecological functions of hilly areas are emphasized, and clarifying the evolutionary characteristics and drivers of production-living-ecology space (PLES) in hilly areas is important for optimizing regional development patterns and promoting environmental quality development. In this study, the current land use status and topographic data of typical hilly areas in southwest China (Changshou District, Chongqing) in 2000, 2010, and 2020 were selected, and the evolution characteristics of PLES and its driving factors were systematically studied by using land use transfer matrix, landscape index and geodetector. The results show that. (1) PLES shows a pattern of one decrease and two increases (production space decreasing year by year, living and ecology space increasing). (2) under the influence of hilly topography, the vertical variation of PLES is obvious with the threshold of 450m in elevation and 9° in slope. (3) PLES landscape diversity increases, dominance increases, and fragmentation increases. (4) Natural conditions, transportation location and socio-economics are important driving factors affecting the evolution of PLES patterns.
The Efficacy of HDDPiW-jSB Solution on Docetaxel-Induced Alopecia of Rats
Authors: Demir Bilgin , Demirci Buket , Tataroglu Canten , Barutca Sabri , Barutca Duygu
Published: May 2023

Objective: Chemotherapy induced alopecia (CIA) is one of the most common side effects in cancer patients, however; it doesn’t have an effective pharmacological treatment yet. In this study we aimed to research the protective effect of HDDPiW-jSB solution on docetaxel (DTX) -induced rat alopecia model.
Material and Methods: Docetaxel (10 mg/kg/week) was administered to the 6-8 months old rats for three weeks. HDDPiW-jSB solution was applied once or twice a week for 4 weeks beginning prior to one week before DTX. Rat hair follicles were evaluated with hematoxylin-eosin and immune-histochemical staining.
Results: In the first stage of this study, alopecia was successfully developed by DTX application. In the second stage, application of HDDPiW-jSB solution without DTX, didn’t change the study parameters significantly. In DTX-induced alopecic rat groups’ skin samples, the solution ameliorated the anagen hair follicle count and Bcl-2 values, especially when used as twice a week. Additionally, level of Caspase 3 was decreased. HDDPiW-jSB solution was safe when applied on the skin.
Conclusion: Topical HDDPiW-jSB solution could be effective and safe for the protection of DTX-induced alopecia in rat models.
Combined BBB-penetrant tyrosine kinase inhibitor and intracranial radiotherapy versus BBB-penetrant tyrosine kinase inhibitor alone for the treatment of EGFR-mutated non-small cell lung cancer patients with brain metastases
Authors: Chen You-Cong , Lee Cheng-Chia , Chiang Chi-Lu , Yang Huai-Che , Wu Hsiu-Mei , Chen Ching-Jen , Luo Yung-Hung , Hu Yong-Sin , Lin Chung-Jung , Chung Wen-Yuh , Shiau Cheng-Ying , Guo Wan-Yuo , Pan Hung-Chi , Lin Chun-Fu
Published: May 2023

Purpose
This study was to determine whether combining blood-brain-barrier-penetrant tyrosine kinase inhibitor (TKI), osimertinib, with intracranial radiotherapy (TKI + RT) would confer benefits exceeding those of osimertinib alone (TKI-alone) in terms of treatment outcomes among non-small cell lung cancer (NSCLC) patients with brain metastases and epidermal growth factor receptor (EGFR) mutation.
Methods
This single-center retrospective study focused on gamma-knife radiosurgery (GKRS) and whole brain radiotherapy (WBRT). Treatment outcomes included intracranial local tumor control, intracranial distant tumor control and overall survival (OS) rates.
Results
This study included 567 brain metastases in 69 patients: TKI-alone (n = 38) and TKI + RT (n = 31) including GKRS (n = 25) and WBRT (n = 6). Intracranial local tumor control at 36 months was significantly higher in the TKI + RT than in the TKI-alone (77% vs. 23%; p < 0.001). Intracranial distant tumor control was significantly higher in the TKI + RT than in the TKI-alone (median survival: 23.2 ± 1.5 vs. 8.7 ± 0.2 months; p < 0.001). We observed no difference between the two cohorts in terms of OS (p = 0.271). T790M point mutation (HR = 0.359, p = 0.008) and TKI + RT (HR = 0.396, p = 0.010) were positively correlated with intracranial local tumor control. The number of brain metastases was negatively correlated with intracranial distant tumor control (HR = 2.253, p = 0.034) and OS (HR = 2.049, p = 0.019).
Conclusions
The efficacy of osimertinib therapy for NSCLC patients with brain metastases and EGFR mutation was enhanced by combining this treatment with intracranial radiotherapy. Benefits were observed in terms of intracranial local control and distant control rates; however, no benefits were observed in terms of OS. Further prospective studies will be required to confirm these findings.
Valid-IoU: An Improved IoU-based Loss Function and Its Application to Detection of Defects on Printed Circuit Boards
Authors: Vakili Elnaz , Karimian Ghader , Shoaran Maryam , Yadipour Reza , Sobhi Jafar
Published: May 2023

A crucial component of quality control during printed circuit board (PCB) production is defect detection. The PCB should be inspected during the manufacturing process in order to minimize defects such as printing errors, incorrect component selections, and incorrect soldering. Convolutional neural networks (CNNs) have become widely used due to their high recognition power. One of the factors affecting the accuracy of CNNs is loss function. Intersection over union (IoU) based loss function and its variants such as IoU, generalized IoU (GIoU), distance IoU (DIoU), complete IoU (CIoU), and improved CIoU (ICIoU) are common metrics for bounding box regression. The IoU-based loss functions, such as ICIOU, achieve remarkable success but still have some main drawbacks such as inaccurate regression. The ICIoU performance is degraded under conditions between the ratio of the corresponding height or width of the predicated bounding boxes and the ground truth bounding box. In this paper, an improved IoU called VIoU is introduced to solve this problem. By incorporating VIoU loss into state-of-the-art YOLOv4 object detection algorithm, an average accuracy of 98.63% on the PCB defect detection is achieved which is an improvement compared to existing IoU models.
Spatial variation of aquifer permeability in the North China Plain from large magnitude earthquake signals
Authors: Gu Hongbiao , Xu Yirong , Lan Shuangshuang , Yue Mingxin , Wang Mingyuan , Sauter Martin
Published: May 2023

Permeability changes induced by earthquakes have been studied widely. However, basic questions still remain: What are the spatial differences in permeability changes induced by far-field earthquakes? Is there an inevitable relationship between seismic energy density, epicenter azimuth and permeability change? We try to answer the above questions by examining records of 11 years of groundwater hydrographs of 7 wells in the North China plain at large distance from the epicenters of 221 earthquakes during the period 2008 ~ 2018. The results shows permeability changes varied between the different wells, with the permeability variation of the JN well most sensitively responding to seismic events, while the least sensitive wells being SH, JZ and LK. We found that the azimuths of seismic waves can greatly influence the changes in permeability, i.e. mainly concentrated between 25° and 295°. The seismic density energy (SDE) value larger than approximately 10-9 J/m3 is likely to induce a change in permeability in the NCP aquifer materials. It is found that SDE is not a predictor of permeability change at a given well, by calculating the seismic energy density which did not cause permeability change. While the permeability change ratio before and after the earthquake can be considered as the ability of permeability respond to the dynamic stress and it shows a weak correlation with depth of aquifer. Thus, Factors that probably affect permeability responses changes would have implications for crustal geomechanics.
H-type indices with applications in chemometrics：h accuracy index (HAI) for evaluating and comparing errors in analytical chemistry
Authors: Xu Lu , Yang Qin , Bian Xihui
Published: May 2023

Inspired by the popular h-index in bibliometrics, an h-accuracy index (HAI) was suggested as a new indicator to evaluate and compare errors in analytical chemistry. HAI simultaneously considers the ‘trueness’ of analytical measurements and the frequency of measurements with high ‘trueness’. HAI was defined as: if the ‘trueness’ of at most M% of the total measurements is no less than M%, the value of HAI will be M%, where a specific definition of ‘trueness’ was given to compute HAI. The range of HAI was between 0 and 1. HAI was used in two problems: (1) as a new index of errors, to evaluate and compare the analytical results by different analytical methods; and (2) to evaluate and compare the prediction performances of different multivariate calibration models. Data analysis indicated that HAI was a reasonable, robust, easy-to-compute, and comprehensive index for evaluating and comparing errors in analytical chemistry.
O direito humano à moradia e a expansão das políticas habitacionais aplicados ao caso do Residencial Cristo Vive em Tucuruí (PA)
Authors: Amaro Correia Marília , Moreira Edma do Socorro Silva
Published: May 2023

Este artigo tem o objetivo de analisar como as políticas habitacionais no Brasil têm sido estabelecidas, sua eficácia e contradições no combate ao déficit habitacional e como elas têm respondido aos critérios de uma moradia adequada, em um contexto amazônico. A pesquisa foi desenvolvida por meio de estudo interdisciplinar entre o Direito e as Ciências Sociais, tendo por aparato teórico, além da literatura acerca do direito à cidade, financeirização da casa própria, e a atuação das políticas habitacionais, os documentos legais apensados ao processo de ocupação do Residencial Cristo Vive, localizado no município de Tucuruí, no Estado do Pará, que sofre os reflexos das políticas desenvolvimentistas de expansão do capital na Amazônia. Percebeu-se que as políticas habitacionais prestam-se a atender ao setor financeiro e imobiliário, invertendo-se os valores em relação aos direitos sociais e que a concentração da política habitacional apenas no foco da aquisição da propriedade privada acabou por dificultar o acesso das pessoas a uma moradia digna.
Trabalho infantil na contemporaneidade: A possibilidade de regulamentação dos influencers mirins à luz dos direitos infantojuvenis
Authors: Gomes Sarah Bianca Silva , Ribeiro Ferreira Façanha Josanne Cristina
Published: May 2023

Este estudo explora a possibilidade de regulamentação do trabalho dos influencers mirins diante da efetivação da proteção integral à criança e ao adolescente. Não se atentando à idade, novas formas de trabalho trazidas pela era digital estão sendo praticadas também por crianças e adolescentes sem haver uma regulação adequada para o seu exercício. Entende-se, assim, que embora o ordenamento jurídico preze pela proteção integral do público infantojuvenil, a legislação mantém-se omissa perante essa realidade que pode trazer consequências desastrosas para o público pueril a curto e a longo prazos. Outrossim, foi necessário apontar como o trabalho infantil se dá na Internet, que, dependendo do seu grau, pode causar consequências como as de cunho mental e social. Dessa forma, conclui-se pela necessidade de uma regulamentação nacional com a finalidade de dirimir eventuais questionamentos e permitir uma fiscalização efetiva. O trabalho exposto utiliza o modelo de pesquisa bibliográfica, buscando demonstrar a necessidade de legislação pertinente, no presente caso exploratória e descritiva, na qual se usa por base material já publicado, como teses e artigos, em caráter hipotético-dedutivo, em que foram realizadas entrevistas com profissionais da área, buscando maior engajamento com a problemática, a fim de promover a integração entre o conhecimento obtido e a sociedade.
THE ANALYSIS OF HADITS HERMENEUTICS BASED ON MUSTAFA AL-SIBA’I'S PERSPECTIVE
Authors: Sholihah Hidayatus , Zaenurrosyid Ahmad , Sarjuni Sarjuni
Published: May 2023

Mustafa Al-Siba’i is a warrior figure for the authenticity of Hadith. After Muhammad, as messenger of God, passed away, some orientalists have emerged who doubt the authenticity of the Hadith. Then Mustafa is one of the figures at the forefront of countering the orientalists who are trying to make Muslims doubt the authenticity of Hadits. This article aims to analyze how Hadith Hermeneutics in the perspective of Mustafa Al-Siba’i. Therefore, who is the figure of Al-Siba’i, what is his educational background and his works will be discussed, before analyzing his thoughts related to the authenticity of the Hadith to find out the style of his thinking. The method applied was library research or reviewing various existing literature, mainly sourced from various journals and books explore about Mustafa Al-Siba’i's thoughts. The results of the study of various literatures explain that Al-Siba’i is an extraordinary scholar and preacher who actively writes and produces various logical, systematic and monumental works. He has written various works to counter the efforts of orientalists or liberal figures to weaken the Muslim community's belief in Hadith. Al-Siba’i's works can influence Muslims to the authenticity of Hadith as Islamic law or the second reference for Muslims after the Qur'an.
MITOS PERNIKAHAN BELIK TARJHE DI DESA PACENTAN MADURA DALAM PERSPEKTIF ‘URF
Authors: Permadi Danur Putut
Published: May 2023

Manusia adalah makhluk unik yang menyandang status makhluk individual sekaligus makhluk sosial. Implikasinya sebagai makhluk sosial adalah dirinya dituntut untuk dapat berhubungan dengan manusia yang lainnya. Salah satu cara berhubungan dengan orang lain adalah menjalani sebuah ikatan pernikahan. Dalam Islam sendiri disebutkan bahwa menikah adalah hal penting dan wajib bagi pengikutnya. Di dalam hukum adat pernikahan ini bukan hanya sebuah ikatan suci antar dua orang, tetapi juga dianggap sebagai ikatan adat. Untuk itulah dalam sebuah adat diatur berbagai hal mengenai pernikahan. Salah satu mitos yang dijadikan sebuah aturan adat adalah mitos larangan pernikahan Belik Tarjhe yang berada di Desa Pacentan. Mitos ini melarang adanya pernikahan antara saudara ipar dengan ipar. Dalam konteks ‘Urf dikenal istilah ‘Urf Shahih dan ‘Urf Fasid. ‘Urf Shahih ini adalah ‘Urf yang diperbolehkan sebagai hukum Islam, sedangkan ‘Urf Fasid adalah ‘Urf yang bertentangan dengan hukum Islam. Dengan menggunakan metode penelitian kualitatif dapat diambil sebuah kesimpulan bahwa terdapat dua pandangan masyarakat dalam menanggapi mitos ini. Yaitu masyarakat yang masih mempercayai dengan kaku dan masyarakat yang moderat. Selain itu apabila ditinjau dari perspektif ‘Urf, mitos ini masuk ke dalam ‘Urf fasid. Hal ini dikarenakan mitos larangan pernkahan Belik Tarjhe bertentangan dengan hukum Islam serta menimbulkan banyak kerugian dalam kehidupan masyarakat setempat
RELEVANSI NILAI PENDIDIKAN ANAK DALAM AL-QUR’AN DI ERA MILENIAL
Authors: Srifariyati Srifariyati , Mamlakhah Mamlakhah
Published: May 2023

Penelitian ini diilhami dengan masih banyaknya anak yang terjerumus kepada pergaulan bebas, merokok, terjerat narkoba, tawuran antar sesama, berani kepada orang tua, dan berkata kotor. Era digital membuat orang mudah memenuhi kebutuhannya, dengan berbagai layanan dapat lakukan dengan mudah lewat internet. Semua keuntungan dan kemudahan tersebut tentunya harus berbanding lurus dengan pendidikan agama. Al-Qur’an banyak menyebutkan tentang nilai pendidikan terutama nilai pendidikan anak.Banyak ayat yang menyebutkan nilai pendidikan anak seperti dalam QS. Luqman ayat 13-15, QS. Al-Ahqaf ayat 15, QS. Al-Isra’ ayat 23-24. Ayat ayat tersebut mengandung perintah tidak boleh menyekutukan Allah, berbuat baik kepada orang tua hingga berbuat baik ketika orang tua  meninggal. Penelitian ini bertujuan untuk menjelaskan: (1) nilai pendidikan anak dalam Al-Qur’an; (2) relevansi nilai pendidikan anak dalam Al-Qur’an di era milenial. Metodologi Penelitian ini bersifat  library research. Subjek dalam penelitian ini adalah anak didik usia sekolah dasar kira-kira umur 7-12 tahun. Dengan menggunakan pendekatan tafsir maudhu’i, yaitu menghimpun seluruh ayat yang memiliki tujuan dan tema yang sama, kemudian kalau mungkin disusun berdasarkan kronologi turunnya dengan memperhatikan sebab-sebab turunnya.  Hasil Penelitian ini adalah (1) terdapat banyak ayat dalam Al-Qur’an tentang nilai pendidikan anak seperti tidak boleh menyekutukan Allah dan harus berbakti kepada kedua orang tua. (2) nilai pendidikan anak yang terkandung dalam Al-Qur’an di era milenial masih sangat relevan antara lain dengan cara menerapkan metode pendidikan keteladanan, pembiasaan, nasehat, perhatian dan pengawasan, dan pendidikan dengan hukuman.
NILAI MODERASI BERAGAMA PADA GAYA ARSITEKTUR MASJID AGUNG SOLO
Authors: Waluyo Waluyo , Dardiri Muhammad Amiruddin
Published: May 2023

Toleransi tidak berhenti pada pemaknaan saling menghargai dan menghormati agama lain akan tetapi dalam berbagai pemahaman dalam satu agama. Moderasi beragama tidak terbatas pada nilai-nilai yang tampak secara eksplisit, akan tetapi nilai implisit. Pemahaman nilai-nilai kontekstual dalam seni arsitektur akan membuka wawasan sehingga tidak sempit pemahaman. Pada satu sisi seni dibutuhkan dan merupakan fitrah manusia, pada sisi yang lain juga ada kelompok-kelompok walaupun sesungguhnya kelompok tersebut sangat sedikit yang berpendapat bahwa kesenian memiliki jumlah mudharat yang banyak, bahkan diantara mereka sampai mengharamkannya. Pelabelan bid’ah menurut peneliti banyak salah terminologi. Bid’ah sebagai obyek hukum bisa memiliki hukum wajib, sunnah, mubah dan haram. Artinya bukan pelabelan sesuatu yang baru, yang tidak ada contoh dari Nabi hukumnya bid’ah tetapi sesuatu yang baru itu bid’ah dan bid’ah memiliki beberapa hukum. Termasuk didalamnya pemaknaan simbol-simbol dan arsitektur masjid Agung Solo, bentuk dari ornamennya merupakan khazanah keilmuan yang memiliki nilai seni budaya dalam pendidikan Islam. Arsitektur masjid Agung Solo terdapat usaha-usaha mengimplementasikan nilai-nilai Islam melalui budaya. Penelitian ini dimaksudkan mengungkap misteri dan makna filosofis, sehingga makna dalam seni budaya arsitektur masjid Agung Solo tidak disalah artikan. Untuk mengungkap makna dasi sisi sejarahnya diperlukan pendekatan kajian historis, kemudian untuk mengungkapkan makna menggunakan telaah filosofis. Sehingga tujuan penelitian menjadi jelas dan terarah. Kurangnya pemahamannya akan latar belakang dari sisi histori dan filosofis nilai arsitektur bangunan, dengan mudah menjustifikasi dengan label bid’ah. Selain tujuan pendidikan Islam dalam nilai arsitektur membanguan nilai toleransi dalam beragama.
Pathogenetic and structural and functional changes in the kidneys after COVID-19
Authors: Kamyshnikova Lyudmila A. , Efremova Olga A. , Pisankina Daria S. , Gorbachevskaya Kristina S. , Pishchanskiy Alexander N. , Sviridova Maria S.
Published: May 2023

There is now a growing evidence of the long-term effects of COVID-19, affecting almost all human systems and organs, including the kidneys. The objective of this paper was to study pathogenetic and structural and functional changes in the kidneys in patients with COVID-19 infection. Materials and methods. Articles were searched in PubMed, Medline, Google Scholar, E-library, Clinical Trial databases using the keywords "post-COVID syndrome," "renal damage (kidney disease)," "COVID-19," "SARS-CoV-2," and "glomerulonephritis" in Russian and English. Databases reporting cases of detectable renal damage following a prior coronavirus infection published by September 28, 2022 were used. This review includes literature reviews, clinical cases, and original studies reporting the confirmed cases of detectable renal damage after confirmed prior COVID-19. The sources that focus only on renal damage during the acute period of coronavirus infection have been excluded. Results. Primary viral damage is carried out through the effect on the receptors of angiotensin-converting enzyme-2 (ACE-2). No less important mechanisms of viral damage are immunological and inflammatory reactions, dysfunctions of the complement system, leading to multiple organ failure. The long-term consequences of coronavirus infection on the kidneys were manifested in a decrease in the estimated glomerular filtration rate (eGFR), an increase in creatinine levels, proteinuria, and microhematuria. Dickkopf-3 protein (uDKK-3) may become a promising marker of kidney damage. Post-COVID renal disease can occur both de novo and with a previous renal complication of COVID-19. The most common morphological variants of kidney damage were tubular lesions and various morphological variants of glomerulonephritis. Conclusion. The association of COVID-19 and kidney damage in the post-COVID period is supported by common mechanisms of pathogenesis, including direct viral damage through ACE-2, inflammatory and immune reactions of the body. These data are confirmed by detectable markers of inflammation and damage to the renal tissue, the morphological picture of necrosis, fibrosis of the renal parenchyma in patients with COVID-19 infection.
Morphological and anatomical structure of flowers and fruits of Sisymbrium officinale (L.) Scop.
Authors: Drozdova Irina L. , Bogoslovskikh Daria D.
Published: May 2023

The genus Sisymbrium L. of Brassicaceae family has up to 90 species of single and perennial herbaceous plants growing in temperate regions of both hemispheres. In Russia there are up to 20 species, of which the most common is Sisymbrium officinale (L.) Scop. This species is widely used in traditional medicine around the world as an expectorant, restorative, diuretic, anthelmintic, for diseases of the digestive and respiratory systems. It is included in the Pharmacopoeia of France. However, it is not included in the State Pharmacopoeia of Russia; the pharmacopoeia article for medicinal plant raw materials has not been approved. The possibility of using a new species in scientific medicine makes it necessary to study the morphological and anatomical structure of the Sisymbrium officinale. Objective: to perform morphological (external) and anatomical (internal) analysis of the structural features of the reproductive organs (flowers and fruits) of the medicinal herb; to establish the signs by which it is possible to make a reliable diagnosis. Materials and methods. The study of morphological and anatomical features of reproductive organs (flowers and fruits) of Sisymbrium officinale was carried out in accordance with the articles of the State Pharmacopoeia of the Russian Federation of the XIV edition. Freshly harvested, dried and fixed raw materials were used for the study. Results. For the first time macro- and microdiagnostic signs of reproductive organs (flowers and fruits) of Sisymbrium officinale were described. Conclusion. For the first time macroscopic and microscopic signs of reproductive organs (flowers and fruits) of Sisymbrium officinale have been identified and described, which can be used to determine the authenticity of raw materials, as well as to develop sections «External signs» and «Microscopic signs» of modern regulatory documentation.
Teologia Johna Henry’ego Newmana i jej ekumeniczne skutki
Authors: Surowiec Paweł Robert
Published: May 2023

Problemem badawczym podejmowanym w artykule jest wpływ pism teologicznych Johna Henry’ego Newmana na anglikanów i katolików, a także skutki, jakie wywarła jego myśl eklezjologiczna na Kościół Anglii i rzymski katolicyzm. Celem artykułu jest przedstawienie ekumenicznego dziedzictwa, jakie wypływa z teologicznych pism Johna Henry’ego Newmana zwłaszcza w dziedzinie eklezjologii. W artykule wyszczególniono elementy tożsamościowe Kościoła, anglikańskie inspiracje Newmanem oraz soborowe odniesienia do jego pism.
Przygotowanie do sakramentu bierzmowania w Kościele w Polsce
Authors: Akonom Jakub
Published: May 2023

Przygotowanie do bierzmowania młodych ludzi staje się dziś jednym z najtrudniejszych wyzwań dla duszpasterstwa w Polsce. Wykorzystywany przez lata tradycyjny i nieco klerykalny model formacyjny można dziś uznać za nieaktualny. Reprezentanci młodego pokolenia, podejmując przygotowanie do sakramentu bierzmowania, dają dziś ostatnią szansę wspólnocie Kościoła. Może ona ją wykorzystać do skutecznej ewangelizacji, bądź też, ufając w klasyczne, nieaktualne metody i założenia formacyjne, wykazać indyferentyzm wobec promowanej przez Ojca Świętego Franciszka koncepcji nawrócenia pastoralnego, tracąc tym samym kontakt z młodymi ludźmi. Perspektywa efektywnego przekazu Dobrej Nowiny kandydatom do bierzmowania, a także wzmacnianie w nich fundamentów wiary jest wyzwaniem duszpasterskim, wymagającym zmiany dotychczasowej mentalności. Młodzi w poszczególnych wspólnotach parafialnych mogą doświadczyć działania Ducha Świętego i piękna żywego Kościoła. Aby tak się stało, należy porzucić formalistyczne myślenie, nastawione bardziej na budowę struktur niż na rozwój duchowy człowieka.
Technological Trends Involving Probiotics in the Treatment of Diabetic
Neuropathy: A Patent Review (2009-2022)
Authors: Silva  Santos Sthefane , de Souza Mariana Bastos , Sales  Lauria Pedro Santana , Lima  Juiz Paulo José , Flora  Villarreal Cristiane , Maurício  Viana Max Denisson
Published: May 2023

Background:

Diabetic neuropathy (DN) causes neuropathic pain, and current treatments
are unsatisfactory. Recently studies have demonstrated an assertive correlation between gut microbiota
and pain modulation.

Objective:

Considering the emerging search for new therapies for the control of DN and the growing
commercial interest in the probiotics market, this study aimed to provide patents on the use of
probiotics in the control of DN.

Methods:

This is a patent prospection performed in the Espacenet Patent database, using the association
of keywords and IPC related to probiotics in medical preparations and foods, from 2009 to
December 2022.

Results:

Results have shown that in 2020, there was a boom in patent filing in the area. Asian
countries accounted for more than 50% of all 48 inventions (n = 48), with Japan as the only applicant
in 2021. Products being developed in recent years point to effects that may represent an advancement
in DN treatment, such as reduced concentration of pro-inflammatory mediators, metabolites
and neurotransmitters release, and hypoglycemic potential. All effects were more related to
the Lactobacillus and Bifidobacterium genera, associated with more than one property mentioned.

Conclusion:

The mechanisms attributed to the microorganisms suggest the therapeutic potential of
probiotics in the non-pharmacological treatment of pain. New applications for probiotics have resulted
from great research interest by academia, but also reflect commercial interests despite the
paucity of clinical trials. Thus, the present work supports the evolution of research to explore the
benefits of probiotics and their clinical use in DN.
ACESSO A VAGAS EM CRECHES PÚBLICAS NO MUNICÍPIO DE RECIFE/PE:
Authors: Da Silva Renan Francelino , França Eduarda Peixoto da Cunha , Nóbrega Flavianne Fernanda Bitencourt
Published: May 2023

O objetivo deste artigo é investigar em que medida os processos estruturais podem servir ou não como uma alternativa para concretizar o direito ao acesso às vagas em creches públicas no município do Recife/PE, previsto nas metas 1.A e 1.B. do Plano Municipal de Educação do Recife. Desenvolve-se uma pesquisa empírica-qualitativa, por meio de estudo de caso. Para isso, elabora-se, inicialmente, uma revisão bibliográfica mediante textos sobre litígios estruturais e processos estruturais. Em seguida, realiza-se uma pesquisa empírica, com abordagem exploratória-descritiva, a partir de dados disponibilizados pelo IBGE e pelo INEP relacionados ao número de matrículas em creches públicas e à taxa de escolaridade no período de 2016 a 2019. Conclui-se que o não acesso às vagas em creches públicas está atrelado a um déficit de vagas em creches no Brasil, problema estrutural tanto no Recife quanto em outros Estados brasileiros; e que os processos estruturais são mecanismos que podem mitigar os efeitos desse déficit, bem como auxiliar na efetividade do direito a ele interligado.
SUPREMO TRIBUNAL FEDERAL DIANTE DA INEFICIÊNCIA PROPOSITAL
Authors: Casimiro Matheus , Braga Albuquerque Felipe
Published: May 2023

a democracia constitucional liberal enfrenta graves ameaças no início do século XXI. Em vez de golpes militares, há um processo de erosão democrática, no qual líderes eleitos utilizam mecanismos constitucionais e legais para minar os fundamentos do regime democrático. Uma das maneiras de promover a erosão é o Executive Underreach, ainda pouco estudado pela doutrina nacional e estrangeira. O artigo analisa o caso de Executive Underreach no Brasil, no contexto da pandemia de Covid-19. A pergunta central é: qual o papel do Supremo Tribunal Federal (STF) diante de casos de Executive Underreach? Mediante estudo bibliográfico e documental, bem como pelo estudo de dois casos relevantes – a proteção de grupos indígenas durante a pandemia e a constitucionalidade da vacinação obrigatória – identificam-se três importantes ações que o STF deve desempenhar: 1. Contribuir com a publicidade das decisões governamentais; 2. Exigir justificação adequada para as decisões do Executivo, que deve atuar pautado por razões públicas; 3. Proteger grupos vulneráveis, que podem sofrer maiores prejuízos com a deliberada ineficiência estatal.
De combinatie werk-gezin en het gebruik van formele kinderopvang bij vrouwen met een migratieachtergrond: een mixed methods-benadering
Authors: Wood Jonas , Majean Lore , Coene Vincent , Vanheeswijck Joost , de Smalen David , Ronda Thomas , Keizer Koen
Published: May 2023

Naar aanleiding van de stijgende vrouwelijke arbeidsmarktparticipatie gedurende de tweede helft van de 20ste eeuw, werd beleid ter ondersteuning van de combinatie werk-gezin in westerse landen geïntroduceerd en uitgebreid. Vanuit internationaal perspectief vertoont België een hoog aanbod aan formele kinderopvang. Niettegenstaande deze gunstige positie, wijst voorgaand onderzoek uit dat de vruchten van dit gesubsidieerde beleid ongelijk verdeeld zijn, met hoger gebruik voor groepen met hogere inkomens of opleidingsniveaus. Dit artikel presenteert een mixed methods-onderzoek naar de combinatie werk-gezin en het gebruik van formele kinderopvang naargelang migratieachtergrond. Kwantitatieve analyses testen verschillende verklaringsgronden voor het differentieel gebruik van formele zorg naar migratieachtergrond, terwijl kwalitatieve analyses retrospectieve levenslopen reconstrueren op vlak van onderwijs, arbeidsmarkt en de combinatie werk-gezin voor Antwerpse moeders van de tweede generatie van Marokkaanse origine. De resultaten laten zich samenvatten in twee conclusies. Ten eerste is bevolkingsheterogeniteit in het gebruik van formele kinderopvang in grote mate een vertaling van ongelijkheden in arbeidsdeelname en -opportuniteiten. De kwantitatieve analyses tonen aan dat deze factoren een aanzienlijk deel van de kloof in het gebruik van formele kinderopvang naar migratieachtergrond verklaren, terwijl de kwalitatieve analyses tal van institutionele, socio-economische en socio-culturele drempels identificeren op de arbeidsmarkt. De tweede conclusie is dat formele kinderopvang een van de componenten van een ruimere zorgstrategie is. De kwantitatieve analyses tonen aan dat informele zorg als alternatief of complement kan dienen ten aanzien van formele zorg. De kwalitatieve analyses duiden op gefaseerde strategieën waarbij het gebruik van (in)formele kinderopvang voorafgegaan wordt door eigen zorg, al dan niet in ouderschapsverlof.
“If you put in the effort, you will get ahead.”: een onderzoek naar de invloed van e-inclusie-initiatieven op burgerschap bij migranten in Antwerpen
Authors: Diels Elien
Published: May 2023

In the master’s thesis on which this article was based, the influence of e-inclusion initiatives on citizenship among migrants in Antwerp was investigated. The central research question is accordingly: What is the influence of e-inclusion initiatives on citizenship among migrants in Antwerp? In an attempt to answer this research question, a qualitative study consisting of 22 interviews with migrants who are former e-inclusion trainees was performed. Respondents who participated in the course five years ago were selected in order to be able to determine an influence of the course on their citizenship practices. The influence of the courses on practices of citizenship, namely employment, social networks and public participation was investigated. Moreover, the subjective experience of citizenship by migrants was investigated. The results of this research showed that respondents experience more opportunities in terms of employment and social networks after following the courses. Respondents also proved to be better in maintaining themselves in the bureaucratic system. The influence on community life turned out to be minimal. Anyhow, the respondents proclaimed that they consider themselves as a fully-fledged citizen of Antwerp. Based on the findings on each of these aspects, policy measures were proposed to improve the Antwerp e-inclusion policy.
Development and Validation of Food Frequency Questionnaire (FFQ) for Ultra-processed Food Consumption among Adults in Malaysia: A protocol study
Authors: Mohd Zawahid Balqis Sofeyya , Buhari Siti Sabariah , Ahmad Sharoni Siti Khuzaimah , Setiyaningrum Zulia
Published: May 2023

This study aims to develop and validate a food frequency questionnaire for ultra-processed food (FFQ-UPF) among Malaysian adults and will utilise a cross-sectional study design. Ultra-processed food items will be identified from the subjects’ three days 24-hour dietary recalls and a primary ultraprocessed food checklist. Frequency options and portion sizes will be determined from the literature review. Expert panels will validate the items’ validity and relevancy and the newly developed FFQ-UPF will be pilot tested to the target population. It will also be validated against three days of 24-hour diet recall and will be retested two weeks after criterion validation.
Estado del cultivo de cacao en La Cordillera nariñense con énfasis en la concentración de cadmio
Authors: Meneses Buitrago Diego Hernán , Lerma Lasso José Libardo , Guerrero Díaz Gissela Fernanda , Cortés Delgadillo Diego Leonardo , Martínez Pachón Eliana , Montenegro Andrea Constanza
Published: May 2023

El cacao es un importante producto de exportación para varios países de América del Sur (Brasil, Colombia, Ecuador, Perú y Venezuela). Dentro de ellos, Colombia ocupa el quinto lugar en producción y cuenta actualmente con el reconocimiento de la International Cocoa Organization (ICCO) por producir un cacao fino y de aroma. La producción de cacao en La Cordillera nariñense se da en diferentes zonas de vida con una amplia gama de ambientes agroecológicos, donde el cacao se adapta de forma diferencial. Esto implica adoptar prácticas adecuadas para la sostenibilidad de este cultivo en distintas áreas de la región, sin perder de vista los altos requerimientos de calidad e inocuidad exigidos por los mercados internacionales. En este sentido, la presencia de elementos como el cadmio constituye un problema de salud pública que amenaza la inocuidad del cacao y sus derivados. También es un factor importante a la hora de comercializar hacia países con normatividades exigentes que regulan y restringen los niveles de este contaminante. Por todo lo expuesto anteriormente, Agrosavia y la Fundación Ayuda en Acción, presentan en este manual las características de producción del cacao y abordan la presencia de este metal pesado con el fin de mejorar la sostenibilidad de este cultivo en la región y promover su comercialización.
Studies on HIV/AIDS Among Students: Bibliometric Analysis
Authors: Wang Na , Zhang Runxi , Ye Zeyan , Lan Guanghua , Zhu Qiuying , Chen Huanhuan , Zhang Xiangjun , Tan Shengkui , Ruan Yuhua , Lin Mei
Published: May 2023

Background

In recent years, HIV infection in students has been an ongoing concern worldwide. A large number of articles have been published; however, statistical analysis of the data presented in these publications is lacking.

Objective

This study aimed to detect and analyze emerging trends and collaborative networks in research on HIV/AIDS among students.

Methods

Research publications on HIV/AIDS among students from 1985 to 2022 were collected from the Web of Science Core Collection. A topic search was used for this study, and articles in English were included. CiteSpace was used to generate visual networks of countries/regions, institutions, references, and keywords. Citation analysis was used to discover milestones in the field and trace the roots of the knowledge base. Keyword analysis was used to detect research hotspots and predict future trends.

Results

A total of 2726 publications met the inclusion criteria. Over the past 38 years, the number of publications annually has been on the rise overall. The United States had the highest number of publications (n=1303) and the highest centrality (0.91). The University of California system was the core institution. The main target population of studies on HIV/AIDS among students were medical and university students. These studies focused on students’ knowledge, attitudes, risk behaviors, and education about HIV/AIDS. The recent bursting keywords (gay, sexual health, adherence, barriers, mental health, HIV testing, stigma, and antiretroviral therapy) revealed research trends and public interest on this topic.

Conclusions

This study identified countries/regions and institutions contributing to the research area of HIV/AIDS among students and revealed research hotspots and emerging trends. The field of research on HIV/AIDS among students was growing rapidly. The United States was at the center, and the University of California system was the core institution. However, academic collaboration should be strengthened. Future research may focus on exploring gay students, sexual health, adherence, barriers, mental health, HIV testing, stigma, and antiretroviral therapy.
ANALISIS PENGHITUNGAN BIAYA SATUAN (UNIT COST) TINDAKAN POLI GIGI KLINIK PRATAMA X MENGGUNAKAN METODE TIME DRIVEN ACTIVITY BASED COSTING
Authors: Erfandi Ahmad  , Diah Ayu Puspandari  , Anastasia Susty Ambarriani
Published: May 2023

Background: The high demand for dental and oral care in the community has led to an increase in Dental Poly visits to the PratamaX clinic. Determining the unit cost of polydental procedures is an important factor in clinic financing and increasing clinic revenue.Until now, the clinic owner has never evaluated the cost of dental poly surgery correctly and has not referred to the cost analysis ofthe service unit.Objective: To analyse the unit cost per Dental Poly procedure at Pratama X Clinic by using the Time Driven Activity Based Costing(TDABC) method.Methods: Descriptive observational study, using primary and secondary data from the clinic with the aim of obtaining a unit costcalculation of dental poly procedures. The design of this research was cross sectional and the type of data used was quantitative data.The results of the calculation and cost analysis to determine the unit costs of dental poly procedures in the form of tartar cleaning, dentalfillings with composite resin materials, tooth extraction and dental braces treatment (fixed orthodontics) by tracing costs related to thecost center of the procedure and other parts. that supports action. Results: Based on the unit cost calculation per procedure at thedental clinic, the Time Driven Activity Based Costing cost system imposed indirect costs in calculating unit costs at the Pratama XClinic. Because the Pratama X Clinic did not accurately classify direct and indirect costs, Pratama X Clinic was not accurate in allocating the costs, number and working hours of ineffective PratamaX Clinic employees.Conclusion: According to the data obtained, the application of Time Driven Activity Based Costing resulted in higher levels of dental care compared to the Pratama X Clinic, except for dental fillingswith small composite resin and dental orthodontics.
RESPONS TINDAK LANJUT REKOMENDASI AUDIT MATERNAL DI KABUPATEN BREBES DAN KABUPATEN BANYUMAS
Authors: Dessyana Iriani  , Eugenius Phyowai Ganap  , Dwi Handono Sulistyo
Published: May 2023

Background:

The number of cases of maternal deaths in several districts is still high and has increased as in Brebes and Banyumas districts. The Maternal Perinatal Audit Policy in the District / City as an effort to reduce the number of maternal deaths is felt to be

unsuccessful. In addition, the extent to which policy makers and implementers respond to or follow up on the results of maternal audit recommendations is still a big question.

Objective: To explore the responses and factors that influence the implementation of follow-up maternal audits recommendations in Brebes and Banyumas Districts.

Methods: This study used a qualitative design with a case study

research design. Data collection techniques through document review, in-depth interviews and focus group discussions with a total of 14 informants.

Results: The immediate response to the follow-up to the maternal audit in Brebes Regency was adequate and in Banyumas District good. Planned responses in both districts were not analyzed in this study because terms of reference for activities is not reviewed.

Based on the characteristics of the problems the Brebes Regency is difficult to control because there are still many problems in the field and Banyumas Regency is easy to control. Based on the Policy Characteristics of the two districts included in the good category and based on the environment the Brebes Regency has not supported

and the Banyumas Regency environment supports the implementation of the follow-up to the maternal audit recommendations.

Conclusion: The response of the regencies is very dependent on leadership to make decisions immediately. The immediate response to the follow-up of the maternal audit in Brebes Regency was sufficient and in Banyumas District was good. It is recommended that the District Health Offices need to make a follow-up SOP on recommendations to the implementation of monitoring and evaluation by adding a reward and punishment system and Brebes Regency should accelerate the process of adding PONEK Hospitals and pay more attention to the principles of response in MDSR.