bluuebunny/crossref_metadata_2025 huggingface dataset:
Окислительная стойкость покрытия ZrSi2-MoSi2-ZrB2-ZrC НА C/C-SiC композите в скоростном высокоэнтальпийном потоке воздушной плазмы
Authors:   ФГБОУ ВО Московский авиационный институт (национальный исследовательский университет), г. Москва, Астапов А.Н. , Жестков Б.Е. ,   ФАУ «Центральный аэрогидродинамический институт им. Н.Е. Жуковского», г. Жуковский, Россия, Погодин В.А. ,   ФГБОУ ВО Московский авиационный институт (национальный исследовательский университет), г. Москва, Сукманов И.В. ,   ФГБОУ ВО Московский авиационный институт (национальный исследовательский университет), г. Москва
Published: July 2023

Исследована окислительная стойкость покрытия на подложке из C/C-SiC композита, сформированного методом обжигового наплавления слоев из порошковой смеси в системе ZrSi2-MoSi2-ZrB2-Si. Испытания окислительной стойкости проводили в условиях взаимодействия с высокоскоростным потоком воздушной плазмы вплоть до 2200оC. Работоспособность покрытия обеспечивается образованием и эволюцией в процессе эксплуатации гетерогенной оксидной пленки на основе боросиликатного стекла, модифицированного цирконием, которая является эффективным барьером для диффузии кислорода, что способствует пассивации процессов окисления. Увеличение рабочих температур свыше 1750-1800оС приводит к испарению стеклофазы с поверхности и образованию пористого термобарьерного слоя на основе ZrO2, содержащего вторичные фазы Mo/MoO2, Mo3Si и Mo5Si3. Градиент температуры, наблюдаемый по толщине покрытия, способствует частичному сохранению стеклофазы во внутренних слоях из-за снижения упругости пара, что приводит к замедлению диффузии кислорода вглубь материала. Определены температурно-временные пределы работоспособности, характеристики уноса массы, каталитической активности и излучательной способности покрытия, а также основные факторы, ограничивающие эффективность его защитного действия.
PHILOSOPHICAL FEATURES OF RESENTMENT IN THE CONDITIONS OF RUSSIAN ARMED AGGRESSION AGAINST UKRAINE
Authors:   Donetsk State University of Internal Affairs, Nikolenko K. V. , Kozynets A. O. ,   Donetsk State University of Internal Affairs
Published: July 2023

Objective. The objective of the article is to determine the ontological and socio-cultural features of resentment in the conditions of Russian armed aggression. Methods. A systematic method is used to study the main components of resentment; a concrete-historical method is applied when studying various historical and philosophical features of the study of resentment; the method of comparative analysis is used when considering resentment as a phenomenon and studying its Russian features; an economic method is applied for analyzing ways of production and their influence on the material level of Russian citizens; an axiological approach is applied to determine the consequences of moral and ethical issues of resentment; the moral and ethical method is valid when considering both resentment itself and for determining social consequences as a result of the full formation of resentment thinking. The scientific principles of the research are the principle of objectivity (when analyzing the results of the resentment process), determinism (used to study resentment as a phenomenon in general and used to analyze the social consequences of economic policy), systematicity (the general presentation of the material based on the holistic perception of resentment in the system of individual, social, international and cultural norms). Results. The study analyzes the features of the emergence, formation and specifics of the manifestation of resentment as an individual and social phenomenon. An attempt is made to analyze the initial factors of Russian resentment and its results in interaction with the international community. Therefore, modern military and social problems call for the research of resentment, for a deeper and systematic study of this phenomenon, in order to understand the configuration of the enemy of Ukraine, and the specifics of his behavior. The results may have prospects in the understanding of such concepts as the limits of aggression, the means of influencing the consciousness of the people, and the way of solving existing confrontations. In general, the philosophical analysis of resentment as a phenomenon provides an opportunity to realize its belonging and to determine its presence as one of the key features of the mass consciousness of the entire Russian people. The analyzed concepts demonstrate not just the essence of the phenomenon of resentment, but reveal the peculiarities of the formation of the idea of an external enemy for the Russian Federation, the motives of extreme actions and measures through a deep analysis of the formation of the phenomenon of resentment and the processes of its rooting in the minds of people, possible scenarios of the future to which the aggressor is capable of resorting.
AN UPDATE ON DOCKING ANALYSIS OF SOME PHARMACOLOGICAL ACTIVITY IN JAPANESE KNOTWEED LEAF COMPOUNDS
Authors: KALİYAPERUMAL Raja , K Dr.tharını
Published: July 2023

The proof of concept presents the results of molecular docking analysis in common Japanese knotweed leaf compounds compared to the four different proteases 4GQQ, 2B17, 2FW3 and 1ZB6 obtained from the Protein Data Bank. Several of these compounds show binding energy for the various proteases and according to our data compare favorably to a known antibacterial, anti-inflammatory, anti diabetic and antioxidant drugs. The advancement of improved docking techniques has also made it possible to more accurately predict the biological activity of substances. This paper provides compounds of a Japanese knotweed plant leaf to determine the result of gas chromatography-mass spectrometry to calculate binding energy compared to standardized drugs. The lowest amount of binding energy for good biological activity. The compound undecane had a higher negative binding energy than 2-hydroxyethyl cyclohexanecarboxylate. As we can see from the docking results, by comparing the values of the binding energies of the four proteins obtained from the protein data bank (PDB) (4GQQ, 2B17, 2FW3 and 1ZB6) we propose that the undecane molecule better is antibacterial, anti-inflammatory anti diabetic and antioxidant nature then cyclohexane carboxylic acid 2-hydroxyethyl ester compound. The DFT results HOMO-LUMO energy difference value (E=-0.44eV) indicated that the compounds more stability and reactivity. So energy difference minimum value of 2-hydroxyethyl clohexane carboxylate has good chemical stability and reactivity nature compared to other compound.
IN SILICO STUDY OF APTAMER SPECIFICITY FOR DETECTION OF ADENOSINE TRIPHOSPHATE (ATP) AS BIOSENSOR DEVELOPMENT FOR MITOCHONDRIA DIABETES DIAGNOSIS
Authors: RUSTAMAN Rustaman , RAFİ RAHMAWAN Rizky , MAKSUM Iman Permana
Published: July 2023

Diabetes Mellitus (DM) is characterized by increased blood glucose levels. It is generally caused by the pancreas' inability to produce insulin due to cell damage or insulin resistance. Due to the inhibition of adenosine triphosphate (ATP) production, which is essential for insulin secretion, one clinical pathology of this complication is insulin secretion dysfunction. Common methods of blood sugar diagnostics cannot distinguish mitochondrial diabetes and can lead to medication errors. Furthermore, an approach was developed through ATP biomarkers using an electrochemical biosensor with the help of an aptamer. However, it remains unknown precisely how and where the molecular interactions between the modified aptamer and ATP occur. Simulations were conducted in this study for 100 ns in silico using the amber18 computer program to determine the stability of the interaction and specificity between aptamer-ATP were compared to ADP and AMP. The results showed that the significant interactions are three hydrogen bonds between ATP and G7, G8, and A24. It was discovered that the aptamer-ATP complex had moderately good interaction and better potential for specificity than ADP and AMP. According to the RMSD, RMSF, and binding energy profiles, the system is still searching for the best conformation, necessitating a longer simulation time and additional studies to optimize the system. As a result, the system can reach a stable state and determine a more accurate energy calculation, hence, it is interpreted according to real applications.
Mimic toxicity of Beta-blocker drugs by structural base descriptors
Authors: TİWARİ Akshay
Published: July 2023

QSAR study has been carried out on the set of 35 Beta-blocker drugs for the modelling of toxicity (Ld50), using topological indices. The stepwise multilinear regression analysis method is used for modelling and the obtained models are critically discussed and examined by various types of cross validation parameters
In silico ADMET, toxicological analysis, molecular docking studies and Molecular dynamics simulation of Afzelin with potential antibacterial effects against Staphylococcus aureus
Authors: LANEZ Elhafnaoui , LANEZ Touhami , ZEGHEB Nadjiba
Published: July 2023

Afzelin has been designed and tested for its in silico antibacterial activity against DNA gyrase complex of Staphyloccocus aureus. The results of the toxicity study indicate that afzelin displayed moderate antibacterial potential against staphylococcus aureus with LD50 = 5000 mg/Kg, which is almost four times and a half weaker than that obtained for the commercial antibiotic chloramphenicol. The afzelin and the commercial antibiotic chloramphenicol were subjected to docking studies to understand their interaction with DNA gyrase complex of Staphyloccocus aureus. Results indicated a good affinity of afzelin to the chosen target with the formation of four hydrogen bonds and binding energy of 29.82 KJ/mol. ADME study shows that afzelin is not inhibitors of CYP450 IA2, 2C19, 2C9, 2D6, 3A4 isoenzymes which suggests a decrease in their plasma concentrations and a rapid elimination route. Molecular dynamics simulations were performed for 10 ns for afzelin using the gromacs package to assess the conformational stability of protein-ligand complexes during the simulation.
Discovery of Repurposable Drugs in the Combination Therapy of Breast Cancer: A Virtual Drug Screening Study
Authors: KIRMIZIAY Ebru , DEMİR Rümeysa , ÖĞÜTÇÜ Ceren , PORTAKAL Hüseyin Saygın
Published: July 2023

Cathepsin D (Cat D) is a lysosomal aspartic acid protease encoded by CTSD gene and has significant biological roles such as degradation of extracellular and intracellular proteins, regulation of apoptosis, hormone processing, antigen processing etc. Furthermore, it is overexpressed by breast cancer cells and it acts a role in many processes affecting the cancer prognosis such as metastasis, angiogenesis, invasion, and drug resistance through regulation of the metabolic pathways and digesting the extracellular matrix (ECM) proteins. Due to that there is no drug targeting Cat D in clinical trial phases, a virtual drug screening in order to reveal possible drugs with high Cat D inhibitory activity from a library composed of 12,111 ligands is carried out with this study. Results have demonstrated that ZINC000003922429 (Adozelesin), ZINC000012358610 (Phthalocyanine), ZINC000051951669 (Bemcentinib), ZINC000003786250 (YM022), and ZINC000150338819 (Ledipasvir) have high binding affinity to Cat D. Among these chemical ligands, YM022 from Drugs in Clinical Trials dataset has been evaluated as most promising one that might be repurposed in the treatment of breast cancer due to its high affinity, convenient ADME and Toxicity properties, and highest bioactivity profiles. However, the possible activity of YM022 should be analyzed with further molecular dynamics (MD) simulations, in vitro and in vivo studies.
Structural, Spectral, Antibacterial and Anticancer Investigations of Synthesized Isoxazole Derivatives
Authors: GÜNEY Elif , SAYİN Koray
Published: July 2023

Cancer is one of the most important diseases threatening human health today, and gastric cancer is among the top five in terms of mortality rate. Synthesized eight isoxazole derivatives were investigated in this study as computationally. Structural properties of them were examined in detail and chemical/electronic properties of these compounds are investigated using contour plot of HOMO/LUMO and molecular electrostatic potential (MEP) map. Anticancer properties of these compounds are investigated using molecular docking calculations against H. Pylori and VEGFR2. Additionally, the pharmacokinetics and pharmacology properties are investigated using ADME and p450 analyses Finally, it was found that compound 5a is the best inhibitor candidate.
A theoretical study of oleuropein derivatives as drugs
Authors: GÖKALP Faik , ERENLER Ramazan
Published: July 2023

Oleuropein is a natural product revealing a large variety of biological activity. The natural products are functionalized to increase the activity in the pharmaceutical industry. Theoretical calculations were carried out for oleuropein derivatives to display the target compound exhibiting the most biological effects. Hence, synthetic chemists are able to get inspired to synthesize the most active oleuropein derivatives. The chemical properties of oleuropein derivatives have been investigated theoretically. Gaussian method was used for quantum calculations of these compounds. The properties of compounds were presented and the utilization of these compounds in pharmaceutical industries was investigated. The quantum calculations revealed that 2H-oleuropein (3) and 4-aminobutyl-2-oleuropein (2) were unstable and were prone to react to the radical compounds.
THE EFFECT OF ORGANIZATIONAL CULTURE, INCENTIVE, AND WORK DISCIPLINE ON EMPLOYEE PERFORMANCE
Authors:   Widya Mandala Surabaya Catholic University, Sinaga Aprillia Lonny , Koesmono Teman ,   Widya Mandala Surabaya Catholic University, Junaedi Christofera Marliana ,   Widya Mandala Surabaya Catholic University
Published: July 2023

This research aims to identify the impact of work environment and career development on job performance. A questionnaire is distributed to administrative employees in Surabaya. The data collected and can be used in hypothesis testing are 101 respondent data. Hypothesis testing was carried out using multiple linear regression in the SPSS 23.0 program. The findings of this study support the research hypothesis, namely that work environment and career development significantly have a positive effect on the job performance of administrative employees in Surabaya.
THE INFLUENCE OF JOB SATISFACTION, WORK MOTIVATION, AND EMPLOYEE COMMITMENT ON EMPLOYEE PERFORMANCE
Authors:   Universitas Katolik Darma Cendika, Sanjaya Michael , Indrawati Lilik ,   Universitas Katolik Darma Cendika
Published: July 2023

Every organization carries out various activities to achieve predetermined goals, but in achieving these goals it often experiences obstacles because the employees they have do not have maximum performance. This research was conducted to determine the effect of job satisfaction, work motivation, and employee commitment on employee performance. The contribution of this research is expected to be able to add information at the theoretical or scientific level of human resource management and also have implications for human resource management in companies. The study used the survey method as a data collection technique, and a questionnaire as an instrument and was distributed to a sample of 138 employees. The data analysis technique used was multiple linear regression and the data processing method used SPSS version 25. The results showed that job satisfaction has a positive and significant effect on employee performance, work motivation has a positive and significant effect on employee performance, and employee commitment has a positive and significant effect on employee performance. For this reason, the importance of PT Salam Pacific Indonesia Lines company management in an effort to improve employee performance needs to pay attention to the factors of job satisfaction, work motivation, and employee commitment.
Persepsi Kepuasan Komunikasi Organisasi Orang Tua Murid Terhadap Pembelajaran Tahfidz Di Sdit Nur Al-Barkah Cibarusah Bekasi
Authors: Dewi Kurniasih  , Al Mukarromah
Published: July 2023

This study aims to provide an understanding related to the perception of satisfaction of parents' organizational communication on learning tahfidz in an Islamic educational institution. This study uses a type of field research (field research) and a descriptive qualitative approach. The technique used to analyze the data is by doing data reduction, data presentation, and drawing conclusions. As for the results of this study, there are 7 points including: first, the teacher's communication climate motivates parents and students in learning tahfidz very well because the teacher always gives enthusiasm and appreciation to students, second, teacher communication to parents, the teacher is always a good listener. good and always provide solutions to tahfidz problems, third, the tahfidz learning system is quite good because every information is conveyed as a whole, fourth, the quality of communication management is quite responsible enough, fifth, informal and horizontal communication between parents and teachers goes smoothly and does not awkward, sixth, communication between parents and teachers is good, parents always accept every instruction given by the teacher, seventh, teacher feedback is always giving praise to children who are successful, and giving advice and encouragement when there are children who have not reached the target of memorization .
KOMUNIKASI BUDAYA GOTONG ROYONG MASYARAKAT GORONTALO TERHADAP DAMPAK BANJIR DI MASA PANDEMI COVID-19
Authors: Yunita Umar
Published: July 2023

Saat pandemi Covid-19 melanda, bencana alam seperti banjir dan longsor terjadi di berbagai daerah di Indonesia, salah satunya di Provinsi Gorontalo. Sejumlah wilayah di sekitar Sungai Bone di Kabupaten Bone Bolango hingga sebagian Kota Gorontalo direndam banjir bandang.Dalam merespon permasalahan lingkungan tersebut, perlu adanya peningkatkan kepedulian dan peran masyarakat berdasarkan semangat kebersamaan, kekeluargaan dan kegotongroyongan. Penelitian ini bertujuan untuk mengetahui aspek budaya, komunikasi, kolaborasi (gotong royong), kesehatan (penyakit), dan ekonomi (permukiman dan potensi sumber daya alam) dari peristiwa banjir di Kabupaten Bone Bolango.Penelitian ini menggunakan metode kualitatif. Pengumpulan data dilakukan dengan observasi, wawancara dan penelaahan dokumen atau literatur. Hasil dari penelitian ini menunjukan bahwa masyarakat tidak hanya diam menghadapi banjir tetapi juga menyesuaikan diri dan sadar untuk melakukan usaha perbaikan atau membangun kesadaran komunikasi terhadap kondisi lingkungan. Komunikasi gotong royong warga terjadi pada saat banjir datang dan pascabanjir. Sementara para warga menunggu bantuan dan melakukan kerja bakti . Penyakit yang muncul di lokasi penelitian adalah penyakit batuk, diare, sakit kepala, kulit gatal dan demam. Kerusakan mulai dari infrastruktur jalan dan jembatan, fasilitas pendidikan, peribadatan, persawahan, perkebunan dan permukiman.
Strategi Guru Dalam Meningkatkan Perkembangan Sosial Anak Usia 5-6 Tahun Di Tk PGRI Dahlia Lombok
Authors: Bintang Shafa Masnaini. Z  , Nisa Ali  , Shafira Ramdhani  , Uswatun Hasanah
Published: July 2023

The purpose of this study was to determine the learning process, social development, teacher strategies in overcoming the problems of social development of children aged 5-6 years. This study uses a descriptive method and a qualitative approach. The data obtained in the form of words and pictures. The data sources consist of 2 teachers and 2 children in different classes. From the results of the study, it was found that in the learning process children aged 5-6 years with social development barriers were equated with children's learning in general, only adjustments were made in the use of learning tools and resources, materials and assessment of the child's condition. In the process of social development, children aged 5-6 years with social barriers tend to be selfish in playing and behaving, being less good at communicating, and causing more problems. The teacher's strategy in overcoming the problem of social development is that the teacher first overcomes it by being soothed with a loving hug, then the child is invited to talk calmly, and is helped to get to know the environment better.
Promoting Health Equity and Reducing Medical Disparities
Authors: Stannard Robin
Published: July 2023

IN A highly current, relevant, and consequential keynote lecture at the American Thoracic Society (ATS) International Conference 2023, Eliseo J. Pérez-Stable, National Institutes of Health (NIH), Bethesda, Maryland, USA, delved into the pervasive disparities in health equity that are seen both in the USA and across the globe. Pérez-Stable focused their lecture on the need for standardized measures and data sets to increase understanding of the socioeconomic factors that contribute to medical disparities. Using clinical examples of tobacco use behavior, asthma epidemiology, lung cancer management, and diversity of medical professionals, Pérez-Stable delved into the nuanced and significant challenge of health disparities.
Analisis Kesalahan Berbahasa Indonesia Youtuber Eropa pada Tataran Linguistik
Authors: Muzaki Helmi , Khusna Nudiyalista , Putri Elzahra Adelia , Putri Rizka Amalia , Melinda Sindi , Kanugrahan Awal Ciptaning , Larasati Auditiya Probo
Published: July 2023

Abstrak. Analisis kesalahan berbahasa pada penutur asing sangat penting untuk dilakukan karena dengan mengetahui kesalahan berbahasa bisa memahami proses pemerolehan bahasa kedua dan membantu memperbaiki kesalahan tersebut. Penelitian ini bertujuan menganalisis dan mendeskripsikan kesalahan penutur asing dari benua Eropa berdasarkan linguistik, yaitu fonologi, morfologi, sintaksis, dan semantik. Metode penelitian ini adalah deskriptif kualitatif. Teknik analisis dalam penelitian iniÂ Â Â  melalui 4 tahap yaitu:Â  (1) menentukan sampel, (2) mengidentifikasi kesalahan, (3) mendeskripsikan kesalahan, dan (4) menjelaskan kesalahanÂ  (Ellis, 1994)Â  Sumber data yang digunakan adalah video unggahan para penutur asing dari benua Eropa. Hasil penelitian ini menunjukkan adanya bervariasi kesalahan berbahasa penutur asing benua Eropa. Pada tataran fonologi, yaitu penambahan, penggantian, pengurangan serta penghilangan fonem di awal, tengah, dan akhir kata. Pada tataran morfologi, yaitu ketidaktepatan penggunaan prefiks, penghilangan prefiks, penghilangan konfiks, dan penghilangan kombinasi afiks. Pada tataran sintaksis, yaitu kesalahan penyusunan frasa, kalimat tidak berpredikat, penghilangan konjungsi, dan penjamakan ganda. Pada tataran semantik, yaitu pemilihan diksi yang kurang tepat. Hasil penelitian juga menunjukkan kesalahan berbahasa terbanyak yang dilakukan oleh penutur dari benua Eropa adalah kesalahan pada tataran fonologi.Â Kata kunci: kesalahan berbahasa, Bahasa Indonesia, Youtuber Eropa
Interferensi Bahasa Betawi Dalam Bahasa Indonesia Pada Tayangan "Obrolan Of The Day"
Authors: Azella Aldafa Nur , Rosalina Sinta
Published: July 2023

Abstrak. Â Penelitian ini bertujuan untuk mendeskripsikan bentuk interferensi bahasa Betawi dalam bahasa Indonesia pada tayangan â€œObrolan Of The Dayâ€ edisi 14 Desember 2020. Peristiwa interferensi dapat terjadi pada ragam lisan, pada tayangan â€œObrolan Of The Dayâ€ edisi 14 Desember 2020 menghadirkan bintang tamu yang merupakan seorang bilingual. Hal tersebut memberi peluang terjadinya peristiwa interferensi pada tuturan bintang tamu. Penelitian ini menggunakan pendekatan kualitatif dengan metode deskriptif. Metode deskriptif digunakan untuk menjelaskan data-data penelitian. Sumber data dalam penelitian ini diperoleh dari tayangan Obrolan Of The Dayâ€ edisi 14 Desember 2020 pada kanal youtube trans7. Teknik pengumpulan data dalam penelitian berupa teknik dokumentasi, simak bebas libat cakap (SBLC) dan catat. Teknik analisis data dilakukan dengan tiga tahap, yaitu reduksi data, penyajian data, dan pembuatan kesimpulan. Hasil dari penelitian ini menunjukan terjadinya interferensi bahasa Betawi dalam bahasa Indonesia. Interferensi terjadi pada bidang fonologi dengan jumlah 6 data, bidang morfologi dengan jumlah 3 data, dan bidang sintaksis dengan jumlah 11 data.Kata Kunci: bahasa betawi, interferensi, sosiolinguistik
Pengembangan Bahan Ajar BIPA dalam Perspektif Etnografi Komunikasi
Authors: Kusumo Galih , Dwi Hadiyanti Agnes Herlina
Published: July 2023

Abstrak. Dalam pengembangan bahan ajar BIPA, pengajar perlu juga melihat bagaimana bahasa tersebut digunakan dalam konteks lingkungan situasi sosial yang sesungguhnya. Bahasa menjadi inti dari komunikasi sekaligus sebagai pembuka realitas bagi manusia dan manusia membentuk kebudayaannya dan masyarakat melalui komunikasi. Untuk dapat mewujudkan hal-hal tersebut dalam bahan ajar, pengajar perlu memperhatikan beberapa faktor seperti analisis kebutuhan, perumusan tujuan pembelajaran, pelacakan latar belakang budaya siswa BIPA, dan identifikasi kemampuan berbahasa siswa BIPA. Dalam pemilihan bahan pembelaran, pengajar perlu memilih bahan-bahan yang otentik dan berorientasi pada budaya. Hal tersebut akan membantu siswa BIPA untuk mampu memahami dan mampu mempraktikkan berbagai pola komunikasi dalam suatu masyarakat dengan baik dan benar.Kata Kunci: Bahan Ajar, Etnografi Komunikasi, BIPA
Komik Digital Berbasis Keberagaman Budaya Indonesia Sebagai Media Literasi Siswa Sekolah Dasar
Authors: Nurjanah Ike , Mudopar Mudopar , Rahayu Ira
Published: July 2023

Abstrak. Penelitian ini bertujuan menyusun Â komik digital berbasis keberagaman budaya Indonesia sebagai media literasi siswa sekolah dasar. Hal ini dilakukan karena berdasarkan hasil analisis awal membuktikan bahwa media yang digunakan oleh guru masih tradisional. Guru hanya memanfaatkan media pembelajaran seadanya, seperti penggunaan media gambar atau media tradisional lainnya, bahkan tekadang dalam proses pembelajaran guru tidak menggunakan media. Kondisi tersebut menyebabkan siswa merasa jenuh dalam proses pembelajaran. Kejenuhan yang dialami oleh siswa berpengaruh juga terhadap hasil dan motivasi siswa dalam pembelajaran. Berdasarkan hal tersebut, peneliti merancang media pembelajaran berupa komik digital. Penelitian ini menggunakan jenis penelitian pengembangan (R&D) dengan model pengembangan ADDIE (Analysis, Design, Development, Implementation, and Evaluation). Data penelitian diperoleh dengan menggunakan angket. Adapun hasil validasi terhadap media komik digital mendapatkan skor rata-rata 93,96% dengan kategori sangat valid, dan hasil kelayakan yang dilakukan oleh validator materi terhadap materi komik digital yang terdiri 2 aspek penilaian yaitu mendapatkan skor rata-rata 98,07%. Validasi yang dilakukan oleh ahli media I mendapatkan skor 93,63%, validasi yang dilakukan oleh ahli media II mendapatkan skor 94,29, validasi yang dilakukan oleh ahli materiÂ  I mendapatkan skor 97,57%, validasi yang dilakukan oleh ahli materiÂ  II mendapatkan skor 98,57% Subjek dari penelitian ini yaitu siswa kelas IV sekolah dasar di SDN 1 Jatipiring. Hasil dari uji coba terbatas dengan penyebaran kuesioner mendapatkan tanggapan bahwa siswa menyatakan sangat setuju bahwa komik digital dapat memudahkan siswa memahami materi pembelajaran, meningkatkan minat baca dan keterampilan literasi siswa. Hasil respon guru terhadap penerapan komik digital berbasis Keberagamaan Budaya Indonesia pada siswa kelas IV SD mendapatkan skor rata-rata 88% dengan kategori sangat layak. Berdasarkan uraian di atas dapat disimpulkan bahwa media komik digital berbasis Keberagaman Budaya Indonesia sebagai media literasi pada siswa kelas IV layak digunakan untuk siswa Sekolah Dasar.Kata Kunci: Media Pembelajaran, Komik Digital, Literasi
Translating Gradiva: Research Notes
Authors: ffrench Patrick
Published: July 2023

In one of the fragments of the lover’s discourse translated by Timothy Matthews in this volume Barthes considers the figure of Gradiva, from Jensen’s tale, engaging thereby with Freud’s essay on ‘Delusions and Dreams in Jensen’s Gradiva’. Gradiva is a figure of a happy outcome, whereby Zoe Bertgang ‘gently’ eases Norbert Hanold out of the psychotic delusion of his amorous fascination. But these dynamics are not as straightforward as they seem; if, as Barthes suggests, the madness of love is all-encompassing, total, what are we to make of Zoe’s devotion, since she splits herself, between Gradiva and Zoe. This paradoxical tension, between loving and being in love, generates further aporia and tension in the translations enacted across the texts of Barthes, Jensen and Freud. These ‘research notes’ on Gradiva enumerate multiple indices of the ‘Gradiva dossier’, opened by Barthes.
PENGARUH CSR TERHADAP KEMAMPUAN INOVASI DAN KINERJA UMKM (STUDI KASUS PENYALURAN DANA CSR PT SPHC PADA UMKM BUNGA KOPENG)
Authors: NURHIDAYAH EVINTA AMALIA , Ni’am Infijarun
Published: July 2023

Penelitian ini bertujuan untuk memberikan bukti empiris mengenai pengaruh Corporate Social Responbility (CSR) terhadap Kemampuan Inovasi dan Kinerja UMKM di Kopeng dan juga untuk mengetahui jika kemampuan inovasi memediasi hubungan antara CSR dengan kinerja UMKM. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif dengan teknik pengambilan data menggunakan metode Purposive Sampling. Sampel yang diambil dan dijadikan sampel penelitian yaitu anggota koperasi Memayu Jogo Tonggo yang berprofesi sebagai penjual bunga. Teknik analisis data menggunakan analisis regresi berganda. Hasil dari penelitian CSR berpengaruh positif terhadap Kinerja UMKM, CSR berpengaruh positif  terhadap Kemampuan Inovasi, Kemampuan Inovasi tidak mempunyai pengaruh terhadap Kinerja UMKM. kemampuan Inovasi tidak memediasi hubungan antara CSR terhadap Kinerja UMKM.
Multicolor flow cytometry-based immunophenotyping for preclinical characterization of nanotechnology-based formulations: an insight into structure activity relationship and nanoparticle biocompatibility profiles
Authors: Newton Hannah S. , Zhang Jenny , Donohue Duncan , Unnithan Ragi , Cedrone Edward , Xu Jie , Vermilya Alison , Malys Tyler , Clogston Jeffrey D. , Dobrovolskaia Marina A.
Published: July 2023

Introduction

Immunophenotyping, which is the identification of immune cell subsets based on antigen expression, is an integral technique used to determine changes of cell composition and activation in various disease states or as a response to different stimuli. As nanoparticles are increasingly utilized for diagnostic and therapeutic applications, it is important to develop methodology that allows for the evaluation of their immunological impact. Therefore, the development of techniques such as immunophenotyping are desirable. Currently, the most common technique used to perform immunophenotyping is multicolor flow cytometry.

Methods

We developed two distinct multicolor flow cytometry immunophenotyping panels which allow for the evaluation of the effects of nanoparticles on the composition and activation status of treated human peripheral blood mononuclear cells. These two panels assess the presence of various lymphoid and myeloid-derived cell populations as well as aspects of their activation statuses—including proliferation, adhesion, co-stimulation/presentation, and early activation—after treatment with controls or nanoparticles. To conduct assay performance qualification and determine the applicability of this method to preclinical characterization of nanoparticles, we used clinical-grade nanoformulations (AmBisome, Doxil and Feraheme) and research-grade PAMAM dendrimers of different sizes (G3, G4 and G5) and surface functionalities (amine-, carboxy- and hydroxy-).

Results and Discussion

We found that formulations possessing intrinsic fluorescent properties (e.g., Doxil and AmBisome) interfere with accurate immunophenotyping; such interference may be partially overcome by dilution. In the absence of interference (e.g., in the case of dendrimers), nanoparticle size and surface functionalities determine their effects on the cells with large amine-terminated dendrimers being the most reactive.
Long non-coding RNA CASC2 regulates osteoblasts matrix mineralization
Authors: Freitas Jaime , Moura Sara Reis , Barbosa Mário Adolfo , Santos Susana G. , Almeida Maria Inês
Published: July 2023

Long non-coding RNAs (lncRNAs) are master regulators of gene expression and have recently emerged as potential innovative therapeutic targets. The deregulation of lncRNA expression patterns has been associated with age-related and noncommunicable diseases in the bone tissue, including osteoporosis and tumors. However, the specific role of lncRNAs in physiological or pathological conditions in the bone tissue still needs to be further clarified, for their exploitation as therapeutic tools. In the present study, we evaluate the potential of the lncRNA CASC2 as a regulator of osteogenic differentiation and mineralization. Results show that CASC2 expression is decreased during osteogenic differentiation of human bone marrow-derived Mesenchymal Stem/Stromal cells (hMSCs). CASC2 knockdown, using small interfering RNA against CASC2 (siCASC2), increases the expression of the late osteogenic marker Bone Sialoprotein (BSP), but does not impact ALP staining level nor the expression of early osteogenic transcripts, including RUNX2 and OPG. Although siCASC2 does not impact hMSC proliferation nor apoptosis, it promotes the mineralization of hMSC cultured under osteogenic-inducing conditions, as shown by the increase of calcium deposits. Mass spectrometry-based proteomic analysis revealed that 89 proteins are regulated by CASC2 at late osteogenic stages, including proteins associated with bone diseases or anthropometric and musculoskeletal traits. Specifically, the Cartilage Oligomeric Matrix Protein (COMP) is highly enhanced by CASC2 knockdown at late stages of osteogenic differentiation, at both transcriptional and protein level. On the other hand, inhibition of COMP impairs osteoblasts mineralization as well as the expression of BSP. The results indicate that lncRNA CASC2 regulates late osteogenic differentiation and mineralization in hMSC via COMP and BSP. In conclusion, this study suggests that targeting lncRNA CASC2 could be a potential approach for modulating bone mineralization.
Herbal medicine and its impact on the gut microbiota in colorectal cancer
Authors: Bu Fan , Tu Yifeng , Wan Ziang , Tu Shiliang
Published: July 2023

It is well-established that there are trillions of gut microbiota (GM) in the human gut. GM and its metabolites can reportedly cause cancer by causing abnormal immune responses. With the development of sequencing technology and the application of germ-free models in recent years, significant inroads have been achieved in research on GM and microbiota-related metabolites. Accordingly, the role and mechanism of GM in colorectal cancer (CRC) development have been gradually revealed. Traditional Chinese medicine (TCM) represents an important source of natural medicines and herbal products, with huge potential as anti-CRC agents. The potential application of TCM to target gut microbes for the treatment of colorectal cancer represents an exciting area of investigation.
Development of a rat model of lymphedema and the implantation of a collagen-based medical device for therapeutic intervention
Authors: Nguyen Dung , Dionyssiou Dimitrios , Zaitseva Tatiana S. , Zhou Anna T. , Sue Gloria , Deptula Peter , Moroz Maxim A. , Tabada Peter , Rockson Stanley G. , Paukshto Michael V. , Cheng Ming-Huei , Huang Ngan F.
Published: July 2023

Secondary lymphedema is a common condition among cancer survivors, and treatment strategies to prevent or treat lymphedema are in high demand. The development of novel strategies to diagnose or treat lymphedema would benefit from a robust experimental animal model of secondary lymphedema. The purpose of this methods paper is to describe and summarize our experience in developing and characterizing a rat hindlimb model of lymphedema. Here we describe a protocol to induce secondary lymphedema that takes advantage of micro computed tomography imaging for limb volume measurements and visualization of lymph drainage with near infrared imaging. To demonstrate the utility of this preclinical model for studying the therapeutic benefit of novel devices, we apply this animal model to test the efficacy of a biomaterials-based implantable medical device.
Cognitive emotion regulation and life satisfaction among students from Mainland China in Malaysian universities
Authors: Weidi Zhou , JeeChing Pang
Published: July 2023

This study investigates the relationship between cognitive emotion regulation and life satisfaction among students from Mainland China in Malaysian universities. It aims to determine the level of life satisfaction, the frequency of using cognitive emotion regulation, the correlation between the two variables, and the predictive factors of life satisfaction. Four hundred and ninety (490) participants were selected from 12 universities in Malaysia through random sampling; 102 for a pilot study and 388 for the final study. A quantitative research design was developed to conduct the investigation using two questionnaires; the Multidimensional Students’ Life Satisfaction Scale (MSLSS) and a Cognitive Emotion Regulation Questionnaire (CERQ). Data were analyzed using the statistical tools SPSS 26 and Smart PLS (SEM) 3.0. The findings showed that a high proportion of participants (72.4%) demonstrated a high level of life satisfaction among students from Mainland China in Malaysian universities and 48.7% of these students always used cognitive emotion regulation. 12.6% of students from Mainland China displayed a low level of life satisfaction and 13.4% rarely used cognitive emotion regulation. In conclusion, there was a significant relationship between cognitive emotion regulation and life satisfaction, in which positive reappraisal, positive refocusing, and refocusing on planning of cognitive emotion regulation had significant predictive powers for life satisfaction among students from Mainland China in Malaysian universities.
Taking equity-mindedness to the next level: the equity-minded organization
Authors: Liera Román , Desir Steve
Published: July 2023

University and college leaders have an espoused interest in racial equity. In recent years, university and college leaders have invested in diversity, equity, and inclusion (DEI) training that focuses on developing individual attributes that reflect equity-mindedness. For example, DEI training efforts have often been focused on helping faculty develop critical race consciousness by raising their awareness of systemic racism in their routine teaching, mentoring, and hiring practices. However, in many cases, DEI training and equity change efforts primarily focus on individual-level change without critically identifying, disrupting, and transforming organizational processes and policies that perpetuate structural racism. In this paper, we synthesized research on race, organizations, and equity-mindedness to argue that racial equity change efforts should aspire to transform universities and colleges into equity-minded organizations. At the organizational level, equity-mindedness has the potential to structure organizational behavior, shape policy development, and frame practitioner and leader understandings of organizational equity issues in ways that are more aligned with their commitments to equity and justice. Through an analysis of higher education equity change efforts, we introduce a framework for equity-minded organizations. Theorizing equity-mindedness at the organizational level creates opportunities for university leaders, stakeholders, and researchers to move beyond the traditional prose of commitments to DEI to the design of programs, policies, and practices that can lead to more lasting structural changes.
Engineering students’ justifications for their selections in structured learning diaries
Authors: Kivimäki Ville , Ketonen Elina E. , Lindblom-Ylänne Sari
Published: July 2023

Introduction

New digital tools such as structured learning diaries (SLD) can serve as both a measurement and intervention tool, at scale. However, we do not yet know how students use the SLD tool and justify their actions within it. Clickable items are easy to use, but do these diaries hold any deeper meaning for students? This study aims to explore the means of justification used by students to create SLD content, their profiles based on these justifications, their levels of reflection, and the relationship between the profiles and use of SLDs.

Methods

We interviewed a sample of first-year master’s-level engineering students to gather justifications and reflections related to the content of their SLDs. Rank- and median-based statistical tests were used to explore the connections between the interview-based profiles, and diary behavior was analyzed through log data.

Results and Discussion

Our findings revealed distinctive profiles with different characteristics related to the structured learning diary behavior, including differences in how changes of difficulty and emotion ratings were made in SLDs. This study opens up a new area for future research and encourages the development of structured learning diary tools as a means of monitoring changes in student thinking at scale.
Intelligent plantar pressure offloading for the prevention of diabetic foot ulcers and amputations
Authors: Hemler Sarah L. , Ntella Sofia Lydia , Jeanmonod Kenny , Köchli Christian , Tiwari Bhawnath , Civet Yoan , Perriard Yves , Pataky Zoltan
Published: July 2023

The high prevalence of lower extremity ulceration and amputation in people with diabetes is strongly linked to difficulties in achieving and maintaining a reduction of high plantar pressures (PPs) which remains an important risk factor. The effectiveness of current offloading footwear is opposed in part by poor patient adherence to these interventions which have an impact on everyday living activities of patients. Moreover, the offloading devices currently available utilize primarily passive techniques, whereas PP distribution is a dynamically changing process with frequent shifts of high PP areas under different areas of the foot. Thus, there is a need for pressure offloading footwear capable of regularly and autonomously adapting to PPs of people with diabetes. The aim of this article is to summarize the concepts of intelligent pressure offloading footwear under development which will regulate PPs in people with diabetes to prevent and treat diabetic foot ulcers. Our team is creating this intelligent footwear with an auto-contouring insole which will continuously read PPs and adapt its shape in the forefoot and heel regions to redistribute high PP areas. The PP-redistribution process is to be performed consistently while the footwear is being worn. To improve adherence, the footwear is designed to resemble a conventional shoe worn by patients in everyday life. Preliminary pressure offloading and user perceptions assessments in people without and with diabetes, respectively, exhibit encouraging results for the future directions of the footwear. Overall, this intelligent footwear is designed to prevent and treat diabetic foot ulcers while enhancing patient usability for the ultimate prevention of lower limb amputations.
Coffee intake and risk of diabetic nephropathy: a Mendelian randomization study
Authors: Fang Jiaxi , Song Kai , Zhang Di , Liang Yan , Zhao Huan , Jin Juan , He Qiang
Published: July 2023

Rationale and objective

A causal relationship concerning coffee intake and diabetic nephropathy (DN) is controversial. We conducted a Mendelian randomization study to assess the causal nature of these associations.

Methods

40 independent single nucleotide polymorphisms (SNPs) associated with coffee intake were selected from the UK Biobank study. Summary-level data for diabetic nephropathy were obtained from publicly available genome-wide association studies (GWAS) and the FinnGen consortium. Inverse variance weighted (IVW), MR-Egger, and weighted median (WM) methods were used to examine a causal association. Sensitivity analyses included Cochran’s Q test, the intercept of MR-Egger, MR-PRESSO, and the Outlier method. Leave-One-Out sensitivity analyses were also conducted to reduce the heterogeneity.

Results

Our current study demonstrated positive associations of genetically predicted coffee intake with diabetic nephropathy (OR=1.939; P = 0.045 and type 2 diabetes with renal complications (OR = 2.787, P= 0.047). These findings were robust across several sensitivity analyses.

Conclusions

This study found a positive correlation between coffee consumption and the risk of diabetic nephropathy using genetic data. For a more accurate and trustworthy conclusion, subgroup analysis on coffee intake, including preparing method, variety of coffee, and quantity, is required.
Predicting diabetic kidney disease for type 2 diabetes mellitus by machine learning in the real world: a multicenter retrospective study
Authors: Liu Xiao zhu , Duan Minjie , Huang Hao dong , Zhang Yang , Xiang Tian yu , Niu Wu ceng , Zhou Bei , Wang Hao lin , Zhang Ting ting
Published: July 2023

Objective

Diabetic kidney disease (DKD) has been reported as a main microvascular complication of diabetes mellitus. Although renal biopsy is capable of distinguishing DKD from Non Diabetic kidney disease(NDKD), no gold standard has been validated to assess the development of DKD.This study aimed to build an auxiliary diagnosis model for type 2 Diabetic kidney disease (T2DKD) based on machine learning algorithms.

Methods

Clinical data on 3624 individuals with type 2 diabetes (T2DM) was gathered from January 1, 2019 to December 31, 2019 using a multi-center retrospective database. The data fell into a training set and a validation set at random at a ratio of 8:2. To identify critical clinical variables, the absolute shrinkage and selection operator with the lowest number was employed. Fifteen machine learning models were built to support the diagnosis of T2DKD, and the optimal model was selected in accordance with the area under the receiver operating characteristic curve (AUC) and accuracy. The model was improved with the use of Bayesian Optimization methods. The Shapley Additive explanations (SHAP) approach was used to illustrate prediction findings.

Results

DKD was diagnosed in 1856 (51.2 percent) of the 3624 individuals within the final cohort. As revealed by the SHAP findings, the Categorical Boosting (CatBoost) model achieved the optimal performance 1in the prediction of the risk of T2DKD, with an AUC of 0.86 based on the top 38 characteristics. The SHAP findings suggested that a simplified CatBoost model with an AUC of 0.84 was built in accordance with the top 12 characteristics. The more basic model features consisted of systolic blood pressure (SBP), creatinine (CREA), length of stay (LOS), thrombin time (TT), Age, prothrombin time (PT), platelet large cell ratio (P-LCR), albumin (ALB), glucose (GLU), fibrinogen (FIB-C), red blood cell distribution width-standard deviation (RDW-SD), as well as hemoglobin A1C(HbA1C).

Conclusion

A machine learning-based model for the prediction of the risk of developing T2DKD was built, and its effectiveness was verified. The CatBoost model can contribute to the diagnosis of T2DKD. Clinicians could gain more insights into the outcomes if the ML model is made interpretable.