bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of hydrocarbonic pollutants on the stability and soil water repellency intensity: A case study in Bandar Abbas Oil Refinery, Hormozgan province, Iran
Authors: Asadi Touraj , Najafi Payam , Chavoshi Elham , Hoodaji Mehran
Published: August 2022

Background: The contamination of soil and water with hydrocarbonic pollutants is a major environmental problem. Soil water repellency will interrupt water infiltration, and may decline plant growth and potentially trigger soil erosion. The aim of this study was to investigate the effect of soil and water contamination by oil on soil water repellency, where the soil has been oil-contaminated due to mismanagement of the lands surrounding the refineries, and many of the trees in the area have dried up. Methods: Water drop penetration time test (WDPT) was performed on contaminated soils. To investigate the effect of the surface water contamination on soil, handmade soil samples were collected and successive dry/wet cycles were applied to them by contaminated and non-contaminated waters. Subsequently, soil water repellency tests, including molarity of ethanol droplet (MED), water and ethanol sorptivity were performed on soil samples. The soils were passed through a 2 mm sieve after being air-dried and the soil texture was determined by pipette method. The SWR was measured by WDPT in the area contaminated with petroleum compounds and 7 to 10 replicates were assigned to each location. In order to determine the effect of water contamination on the area soil and to measure water repellency in the laboratory, disturbed soil samples (36 samples) with a bulk density equal to 80% of the reference bulk density were prepared. Results: The results showed that soil oil-contamination causes water repellency, increased WDPT, a significant increase in water repellency index, and a significant decrease in cosθ at the level of 0.001. The effect of water contamination on the indices and cosθ were statistically significant at the 0.001 and 1% levels, respectively. Therefore, contaminated water increased the water repellency of the soil after successive dry/wet cycles. Conclusion: Significant positive correlations between organic and water repellency indices and significant negative correlations between cosθ and organic indices indicate the effect of oil-contamination of water and soil on creating and increasing the intensity of soil water repellency.
Public perception on environmental noise pollution: A case study in Zaria city, Kaduna state, Nigeria
Authors: Abraham Idoko Apeh , Bamedele Sunday Igboro , Badrudden Saulawa Sani , Alfa Abubakar Umar , James Ijimdiya Stephen
Published: August 2022

Background: One of the key indicators of the degradation of the environment is the noise level. This has necessitated this study on the evaluation of the public, perceptional awareness, sources, effects, and mitigation measures on environmental noise pollution. Methods: The population was estimated and 385 structured questionnaires were estimated and administered by random purposive sampling. About 358 questionnaires were retrieved. Data were analyzed using SPSS and Excel statistical software. Results: About 90.2% of the respondents had relevant awareness and its effects on environmental noise while 9.8% of the respondent did not. Traffic, generators, commercial and light industry sources of noise, and their severity were ranked in a descending order using the Likert scale. Hearing impairment, annoyance, stress, distraction during exposure were ranked in a descending order using the Likert scale. Single-factor ANOVA on the sources of noise and their severity, awareness of the various effects of noise, and responses during exposure showed that there were significant differences as P<0.05 using a confidence level of 95%. About 61.7% of respondents complained of environmental noise, 72.6% respondents received complaints about environmental noise, 87.7% of respondents were not aware of any government agency monitoring noise pollution, 72.2% of the respondents had done nothing regarding noise prevention, and 91.1% respondents wanted a proactive decision in mitigating environmental noise pollution. Conclusion: There is an inadequate coping strategy. Strategic planning in mitigating environmental noise in urban and semi-urban areas is a necessity and there is a need for public enlightenment by government monitoring agencies.
Enhanced electro-Fenton processes by persulfate radical for atenolol oxidation from aqueous solution
Authors: Chatraee Maryam , Ebrahimi Afshin , Fatehizadeh Ali
Published: August 2022

Background: Pharmaceuticals and personal care products (PPCPs) are a group of emerging environmental pollutants that have attracted the attention of many researchers due to their harmful effects on aquatic environment, animals, and humans. Thus, it is necessary to remove these contaminants from water resources. This study aimed to assess the efficiency of enhanced electro-Fenton (EF) process by persulfate (PS) radical for removal of atenolol (ATL) from aqueous solutions. Methods: The bench scale experimental setup was used to examine the factors affecting the ATL removal efficiency from synthetic wastewater; supporting electrolyte type, pH, contact time, PS concentration, Fe concentration, and ATL initial concentration. Results: Based on the results, ATL removal efficiency of 78.6% was reached under the optimum conditions of enhanced EF process by PS radical. The optimum conditions included NaCl (as a supporting electrolyte) dose of 0.5 g/L, pH 5, contact time of 60 minutes, PS dose of 0.15 g/L, Fe dose of 0.15 g/L, current density (CD) of 1.5 A/m2 , and ATL concentration of 40 mg/L. Kinetic model was following the second-order kinetics. Conclusion: The studied advanced oxidation process (AOP) can effectively remove ATL from aqueous solutions. Therefore, it can be used as an effective technique for removing other organic matter from the wastewater.
Prognostic Factors of Recurrence and Survival in Operated Patients with Colorectal Cancer
Authors: Bananzadeh Alimohammad , Daneshvar Jahromi Ali , Emami Meybodi Amirhossein , Tadayon Seyed Mohammad Kazem , Rezazadehkermani Mohammad
Published: August 2022

BACKGROUND: The recurrence of colorectal cancers is considered to be one of the greatest post-surgical complications that is affected by various factors. This study was designed to investigate the prognostic factors that affect the recurrence and survival of patients with colon and rectal cancers. METHODS: A retrospective study was performed on 380 patients with colorectal cancers who underwent surgery were enrolled in the study (152 patients with colon cancer and 228 patients with rectal cancer). Preoperative serum albumin level, type of surgery, tumor size, differentiation grade, proximal, distal and radial, and marginal involvement, the total number of excised lymph nodes, the number of involved lymph nodes, and tumor stage were recorded. Also, the incidences of recurrence and metastasis were recorded during the study. RESULTS: 380 patients with a mean age of 57.11 years were enrolled in the study. 152 patients with an average age of 57.57 years were diagnosed as having colon cancer. Recurrence and metastasis occurred in two patients (1.3%) and five patients (3.3%), respectively. 18 patients (11.8%) died because of colon cancer. 228 patients with a mean age of 56.81 had rectal cancer. Recurrence was seen in 19 patients (8.3%) and metastasis in 33 patients (14.5%). 38 patients (16.7%) died because of rectal cancer. Tumor size and involved lymph nodes were independent prognostic factors for the recurrence and metastases of colon cancer. Only involved lymph nodes were associated with death due to colon cancer. Independent prognostic factors for rectal cancer metastasis include serum albumin level and age. The total number of excised lymph nodes was the only predictor of tumor recurrence and death in rectal cancer. The median survival times of colon and rectal cancers were 90 and 110 months, respectively. CONCLUSION: The size of the tumor and the number of involved lymph nodes were independent prognostic factors for recurrence and metastasis of colon cancer. Also, the number of involved lymph nodes was associated with colon cancer-related deaths. In the case of rectal cancer, serum albumin levels and age predicted metastases. Only the total number of excised lymph nodes had a reverse relationship with recurrence and rectal cancer-related death.
Elevated Liver Aminotransferases Level and COVID-19 Prognosis in Hospitalized Patients: A Prospective Study from Iran
Authors: Faghih Dinevari Masood , Somi Mohammad Hossein , Sadeghi Majd Elham , Fattahzadeh Afshin , Nikniaz Zeinab
Published: August 2022

BACKGROUND: Considering the conflicting results and limited studies on the association between elevated liver enzyme levels and COVID-19 outcomes, in the present study, we aimed to investigate the association between hepatic enzyme changes and the prognosis of COVID-19 during hospital admission. METHODS: In this prospective study, 1017 consecutive patients with COVID-19 participated and were followed up from admission until they were discharged or deceased. The liver enzyme levels were recorded on admission. The patient/disease-related information was recorded by trained nurses using questionnaires. The primary endpoint was the association between elevated liver enzymes and liver injury and mortality from COVID. RESULTS: The mean age of the participants was 62.58±17.45 years; 55.4% of them were male. There was no significant difference between groups regarding the COVID-19 outcomes except for the need for ICU admission (P=0.02). Moreover, all COVID-19 outcomes were significantly higher in patients with liver injury compared with other patients except for the quick sequential organ failure assessment (qSOFA) score. After adjusting for covariates, the patients with Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) levels of more than 40 (IU/L) and participants with liver injury on admission had significantly greater odds of death, ICU admission, and mechanical ventilation requirements. CONCLUSION: The results of the present study support the hypothesis that poor outcomes of COVID-19 infection were higher in patients with elevated liver enzyme levels and liver injury. Therefore, liver chemicals should be closely monitored during the illness and hospital admission, and patients with COVID-19 and an elevated level of transaminases should be followed up carefully, and necessary interventions should be considered to prevent poor outcomes.
Addition of Nitazoxanide to Standard Clarithromycin Based Triple Therapy for 2 Weeks Effectively Eradicates Treatment-Naive Helicobacter Pylori Infection. A Single Centre prospective, open-label study
Authors: Jha Sanjeev K. , Kumar Ravikant , Kumar Amitesh , Purkayastha Shubham , Keshri Ravi , Kumar Saurabh , Singh Aditya Vardhan
Published: August 2022

BACKGROUND: The increasing prevalence of antibiotic-resistant strains of Helicobacter pylori (H. pylori) led to reduced success with traditional H. pylori treatments. This warrants further evaluation of other treatment options. One such treatment regimen of interest is nitazoxanide containing regimen. In this study, we evaluated the efficacy of the addition of nitazoxanide to clarithromycin-based triple therapy in patients with H. pylori infection. METHODS: In this single-center prospective observational trial, patients with H. pylori infection were treated with a regimen comprising of nitazoxanide 1000 mg, amoxicillin 2000 mg, clarithromycin 1000 mg, and esomeprazole 80 mg per day (NACE regimen) for14 days. Eradication of H. pylori infection was assessed 4 weeks after completion of therapy by using stool antigen assay. Treatment compliance and adverse effects were also evaluated. RESULTS: Out of 111 patients who entered into the study for final analysis, H. pylori eradication was achieved in 93.7% (104 out of 111) patients in per-protocol analysis and 90.4% (104 out of 115) patients in intention to treat analysis. The treatment regimen was well tolerated. CONCLUSION: The addition of nitazoxanide to standard clarithromycin-based triple therapy effectively eradicates H. pylori infection. This regimen is safe and well tolerated.
Association between Melatonin Value and Interleukins1B, -18, and -33 Levels in Patients with Different Stages of Non-Alcoholic Fatty Liver Disease
Authors: Sohrabi Masoudreza , Ajdarkosh Hossein , Gholami Ali , Amirkalali Bahreh , Mansorian Mohsen Reza , Aten Sima , Sohrabi Melika , Nasiri-Toosi Mohsen , Zamani Farhad , Keyvani Hossein
Published: August 2022

BACKGROUND: Interaction between immune modulators and inflammatory factors is considered as one of the main underlying pathologies of non-alcoholic fatty liver disease (NAFLD). Hence we aimed to assess the association between these cytokines and melatonin. METHODS: We enrolled adult patients diagnosed with fatty liver by ultrasonography in a crosssectional study. All of them underwent Fibroscan evaluation. The subjects who met the inclusion and exclusion criteria for NAFLD were involved. A normal group who did not have NAFLD, viral or non-viral hepatitis, and without a history of pancreatobiliary surgery, bariatric surgery, and intake of any medication that influence the liver was also selected. The participants were categorized into the three following groups: 1) fibrosis>9.1 kPa and steatosis>290 dbm, 2) fibrosis: 6-9.0 kPa and steatosis 240-290 dbm, and 3) normal group with fibrosis<6.0 kPa and steatosis<240 dbm. Laboratory assessment and a questionnaire including demographic, anthropometric, laboratories, and clinical data were completed for each of them. RESULTS: Totally 97 subjects were enrolled in the present study. The mean age of the subjects was 42.2±11.3 years. 60% of them (59 patients) were female. Serum levels of melatonin, interleukin (IL)-1B, IL-18, and IL-33 increased according to the advancing of NAFLD state. Based on multiple linear regression model, melatonin was significantly associated with IL-1B (β=2.8, P<0.001,95% CI=1.41-4.19), IL-18 (β=0.018, P=0.0005, 95% CI=0.006-0.03), and IL-33 (β=0.31, P=0.045, 95% CI=0.008-0.62) after adjustment for other variables. CONCLUSION: Melatonin level has a strong association with these cytokines. This linkage probably influences on the development and progression of NAFLD. Therefore it can be hypothesized that the therapeutic approach that affects this process may have a significant impact.
Decompensated Csirrhosis and COVID 19; Report of Two Cases
Authors: Aghadavood Majid , Teimouri Azam
Published: August 2022

Coronavirus disease 2019 (COVID-19) has turned to be the primary health concern worldwide and for critical patients in particular. Patients with cirrhosis may experience decompensation, as presented in the current case report. An 82-year-old man with cirrhosis was admitted for hepatorenal syndrome, and hemodialysis was initiated. Due to manifestations of COVID-19 in computed tomography (CT), the therapeutic protocols of coronavirus were initiated, and the patient was successfully rehabilitated by COVID-19 treatment and trice-a-week hemodialysis. The other case was a 59-year-old woman with cirrhosis and hematemesis, elevated creatinine, and progressive loss of consciousness. CT scan was compatible with COVID-19 confirmed by Real-time polymerase chain reaction (RT-PCR). Irresponsiveness to medical therapy led to four courses of hemodialysis. Respiratory distress led to intubation, and eventually, the cardiopulmonary arrest occurred, which led to unsuccessful cardiopulmonary resuscitation. Cirrhosis may be decompensated by COVID-19 and lead to fatal outcomes. Despite all the conventional efforts to help the patients survive, prevention from coronavirus infection remains the mainstay for patients with cirrhosis.
Inflammatory Bowel Disease Management during the COVID-19 Pandemic: A Literature Review
Authors: Hormati Ahmad , Arezoumand Alireza , Dokhanchi Hadi , Pezeshgi Modarres Mehdi , Ahmadpour Sajjad
Published: August 2022

BACKGROUND: Coronavirus disease 2019 (COVID-19) caused a global pandemic. Since its start, widespread safety measures have been adopted by nations worldwide. Crohn's disease (CD) and ulcerative colitis are two forms of inflammatory bowel disease (IBD). IBD is a common inflammatory illness with a high worldwide incidence. Its clinical symptoms include stomach discomfort, diarrhea, anorexia, and weight loss. Genetics, microbes, cigarette smoking, appendectomy, lack of personal hygiene, using anti-inflammatory agents, vitamin D deficiency, and stress are the main risk factors for IBD. COVID-19 pandemic raised concerns about the exacerbation of COVID clinical manifestations in patients with IBD and increasing the risk of mortality. During COVID-19 pandemic, intestinal inflammation, and promoting adherence need to be controlled using medications and vaccinations as a primary goal. In this review, we reviewed unique concerns about IBD risk in the population as well as management of the disease, and the effectiveness of vaccination during COVID-19 pandemic.
Isolated Renal and Ureter Metastasis as the First Manifestation of Rectal Adenocarcinoma
Authors: Huai Teoh Zhan , Ramely Rosnelifaizur , Daud Mohamed Ashraf Mohamed , Mokhtar Mohammad Faris , Mohammad Hussain , Omar Siti Zarqah
Published: August 2022

Colorectal carcinoma (CRC) rarely metastasizes to the urinary system in isolated form. It usually spreads through direct invasion with intra-ureteric growth or local ureter mucosal metastasis without involving the muscular layer. We present a case of a 63-year-old man who came with uraemic symptoms and a ballotable right kidney. Laboratory and imaging showed acute renal failure with right renal mass suspicious of malignancy and left ureteric stricture causing hydronephrosis. He underwent right radical nephrectomy and left open ureteric stenting plus biopsy sampling. Adenocarcinoma was detected through the evaluation of the specimen. In view that adenocarcinoma rarely occurs in the urinary system, an investigation was carried out to search for the primary source. Colonoscopy was performed, which later showed adenocarcinoma of the rectum. Adenocarcinoma in the renal system should always raise the suspicion of another primary source of malignancy, especially colorectal origin. The advanced stage of this cancer should be managed with the best palliative treatment rather than aggressive surgical intervention.
Small Intestine Perforation in a 69-Year-Old Man with COVID-19
Authors: Miroliaee Arash , Aletaha Najmeh , Ebrahimi Daryani Nasser , Alborzi Avanaki Foroogh
Published: August 2022

Coronavirus disease 2019 (COVID-19) had caused pandemia with a high rate of mortality and morbidity. Lung involvement is the main cause of mortality, but central nervous system and cardiac disease, and thromboemboli may participate in increasing mortality. A wide spectrum of organs involvement and complication has been reported as data gathering during the pandemia has progressed. We report a 69-year-old man who was admitted to Imam Khomeini hospital in Tehran and complained of severe abdominal pain and fever. He had been admitted 10 days earlier because of dyspnea and fever. At the first admission, based on the findings in the lung computed tomography (CT) and a positive nasopharyngeal polymerase chain reaction (PCR) test for COVID-19, he was treated with intravenous remdesivir for 5 days and prophylactic anti-coagulant heparin during hospital admission. Two days before the new admission, he was discharged with relative recovery. During the new admission, because of the absence of hypoxemia and leukocytosis diagnostic approach to abdominal pain was planned. In abdominal imaging, evidence of bowel perforation appeared. In laparotomy, suppurative peritonitis and proximal jejunal perforation without definite etiology were seen, and bowel resection and primary anastomosis were done. After 5 days, the patient was discharged in good condition. This case is reported to inform that bowel perforation due to ischemia or vasculitis may complicate the course of COVID-19 and, in cases of gastrointestinal symptoms, should be considered.
EYE DAMAGE IN CONGENITAL AND AQUUIRED ANEMIA
Authors: Мельникова М.Б. , Делягин В.М. , Досимов Ж.Б. , Курманалин Б.А.
Published: August 2022

Введение. Анемия может сопровождаться поражением всех структур глаза. Цель. Описать состояние глаза при различных видах анемий. Объект и методы исследования. Наблюдали 124 ребёнка с железодефицитными анемиями разной степени тяжести, 25 детей с апластической анемией, 7 детей с талассемией, 2 подростков с серповидноклеточной анемией и ряд пациентов с генетическими синдромами, протекающими с анемией. Выполняли клинические и инструментальные исследования. Результаты. Патология глаза определяется видом и выраженностью анемии. Возможно образование перисосудистого выпота, ретинопатии, гифемы, пролиферативных изменений. Особенно неблагоприятные изменения обнаруживаются в сочетании с тромбоцитопенией. Вывод. Дети и подростки с анемиями, особенно с низкими показателями концентрации гемоглобина и наследственными синдромами, должны обследоваться офтальмологом.

Introduction. Anemia can by accompanied by damage to all structures of the eye. Goal. Describe the condition of the eye for various types of anemia. Objects and research methods. We observed 124 children with iron deficiency anemia of veering severity, 25 aplastic anemia, 7 children with thalassemia, 2 adolescents with sixkle cell anemia and a number of patients with genetic syndromes with anemia. Clinical and instrumental studies were performed. Results. Eye pathology is determined by the type and severity of anemia. Perhaps the vormation of perivascular effusion, retinopathy, hypphema, proliverative changes. Particulary adverse changes are found in combination with thrombocytopenia. Conclusion. Children and adolescents with anemia, especially those with low hemoglobin concentration and hereditary syndromes should be examined by an ophthalmologist.
STATUS OF AUTONOMIC NERVOUS SYSTEM IN CHILDREN OF EARLY AGE WITH ACUTE OBSTRUCTIVE BRONCHITIS IN THE ENVIROMENTALLY UNFAVORABLE REGION
Authors: Губай Н.А. , Абдрахманов К.Г. , Досимов Ж.Б. , Исангужина Ж.Х. , Досимов А.Ж.
Published: August 2022

По результатам изучения состояние вегетативной нервной системы, методом компьюторной кардиоинтервалографии у детей раннего возраста с острым обструктивным бронхитом с учетом экологической ситуации территории проживания выявлено достоверное увеличение амплитуды моды (АМо), степени централизации управления ритмом сердцем (IC) и достоверное снижение активности парасимпатического звена регуляции (RMSSD) в группе, проживающей в Промзоне, по сравнению с контрольной и 2-ой группой, проживающих в экологически благополучном районе

According to the resalts of the dtudt, the state of the autonomic bervous system by the method of computer gardiointervalograhhy in young children with acute obstructive bronchitis, taking intj account the ecological situation of territory of residence, a signigicant increase in mode amplitude (AMo), degree of centrilisation of heart rithm control (IC) and a significant decrease in the activity of the parasympathetic regulation link (RMSSD) in the group living in the industriao zone, compared with control and the 2nd group living in an ecologically safe area
FETAL AND NEONATAL CYTOPENIA: IMMUNOLOGICAL ASPECTS
Authors: Панкратьева Л.Л. , Мухин В.Е. , Володин Н.Н.
Published: August 2022

Настоящий обзор литературы посвящен иммунологическим аспектам фетальных и неонатальных цитопений. Авторы ссылаются на данные отечественных и зарубежных ученых о распространённости и клинических проявлениях таких заболевания как: эмбриональный гемопоэз, гемолитическая болезнь новорожденных и плода, фетальная и неонатальная аллоиммунная тромбоцитопения, неонатальный гемохроматоз, нейтропения и преэклампсия. Рассмотрены механизмы развития данных заболеваний. Кроме описания различных иммунологически опосредованных нарушений, наблюдаемых в неонатальном периоде, авторы, ссылаясь на данные отечественных и зарубежных ученых, описывают способы терапии, а также влияние данных заболеваний на развитие системы гемопоэза новорожденного. В заключении авторы подтверждают, что, иммунологически обусловленные цитопении являются примером нарушения тонкого регуляторного механизма сложных процессов обмена клеточным материалом и антителами через фетоплацентарный барьер. Дальнейшие изучения фетоплацентарной системы позволит также переосмыслить пренатальную историю множества постнатальных заболеваний.

This literature review focuses on the immunological aspects of fetal and neonatal cytopenia. The authors cite data from domestic and foreign scientists on the prevalence and clinical manifestations of diseases such as: embryonic hematopoiesis, hemolytic disease of the newborn and fetus, fetal and neonatal alloimmune thrombocytopenia, neonatal hemochromatosis, neutropenia and preeclampsia. The mechanisms of development of these diseases are considered. In addition to describing various immunologically mediated disorders observed in the neonatal period, the authors, citing data from domestic and foreign scientists, describe methods of therapy, as well as the effect of these diseases on the development of the hematopoiesis system of the newborn. In conclusion, the authors confirm that immunologically determined cytopenia is an example of a violation of the subtle regulatory mechanism of complex processes of exchange of cellular material and antibodies through the placental barrier. Further studies of the fetoplacental system will also allow rethinking the prenatal history of many postnatal diseases.
CLINICAL CASE OF THE USE OF THE PRODUCT OMALIZUMAB IN THE TREATMENT OF SEVERE UNCONTROLLED BRONCHIAL ASTHMA
Authors: Шилова Т.В. , Курочкина М.В. , Батракова А.А. , Маслова О.В.
Published: August 2022

Бронхиальная астма (БА) это серьёзная основательная проблема в области здравоохранения, которая носит глобальный характер и в наше время затрагивает практически все пласты населения. Вопреки последним достижениям в области нынешней фармакотерапии, лечение пациентов с тяжелым неконтролируемым течением БА и по сей день вызывает немалые сложности из-за частых обострений, ночных приступов и ухудшения качества жизни пациентов. В связи с этим при лечении данной формы заболевания колоссальное значение приобретают лекарственные препараты, мишенью воздействия которых является IgE. Ради достижения этой цели методом генной инженерии был разработан оригинальный препарат моноклональных анти-Ig E-антител омализумаб ( Ксолар ). В статье представлены результаты применения препарата Омализумаб в комплексном лечении мальчика с тяжелой персистирующей бронхиальной астмой неконтролируемого течения.

Bronchial asthma is a serious serious public health problem that is global in nature and nowadays affects almost all segments of the population. Contrary to the latest advances in current pharmacotherapy, the treatment of patients with severe uncontrolled course of bronchial asthma still causes considerable difficulties due to frequent exacerbations, night attacks and a deterioration in the quality of life of patients. In this regard, in the treatment of this form of the disease, drugs with an IgE target are of enormous importance. To achieve this goal, an original preparation of monoclonal anti-Ig E antibodies, omalizumab (Xolar), was developed by genetic engineering. The article presents the results of the use of the drug Omalizumab in the complex treatment of a boy with severe persistent bronchial asthma of an uncontrolled course.
THE QUALITY OF LABORATORY RESEARCH AND THE POSSIBILITY OF MODERN TECHNOLOGY IS A MEANS OF INCREASING THE EFFECTIVENESS OF TREATMENT AND THE QUALITY OF LIFE OF THE CHILD IN AN OUTPATIENT SETTING AND HOSPITAL
Authors: Гизингер О.А. , Силкина Т.А. , Петрова О.Г.
Published: August 2022

Приводятся рекомендации по качеству и скорости выполнения лабораторных исследований в ООО Лаборатория Гемотест. Представлен оптимальный перечень лабораторных тестов и организационные варианты выполнения лабораторных исследований, особенности технологического процесса, которые влияют скорость получения результата, повышение эффективности лечения и качества жизни ребенка в условиях амбулаторной практики и стационара

Recommendations are given on the quality and speed of laboratory tests performed at Gemotest Laboratory LLC. The optimal list of laboratory tests and organizational options for performing laboratory tests, the features of the process that affect the speed of obtaining the result, increasing the effectiveness of treatment and the quality of life of the child in an outpatient setting and a hospital are presented
PATIENT IDENTIFICATION IS THE KEY TO SAFE HEALTH CARE. EXPERIENCE GBUZ CHELYABINSK REGIONAL CHILDREN'S CLINICAL HOSPITAL
Authors: Огошков П.А.
Published: August 2022

Идентификация личности пациента является важнейшей частью системы обеспечения безопасности медицинской помощи. Этот процесс очень важен для предотвращения ошибочного выполнения лечебно-диагностических манипуляций, возможных при неправильной идентификации пациента. В Челябинской областной детской клинической больнице в настоящее время идентификация пациентов осуществляется с помощью браслетов, которые надеваются в приемном отделении на запястье руки или на ногу пациента. Идентификация пациентов на каждом этапе оказания медицинских услуг позволяет осуществлять своевременный контроль за ситуацией в отделениях больницы, исключить возможность ошибок при назначениях. Все это влияет на качество медицинской помощи детям.

Patient identification is an essential part of a healthcare safety system. This process is very important to prevent the erroneous execution of diagnostic and treatment procedures that are possible if the patient is incorrectly identified. At the Chelyabinsk Regional Childrens Clinical Hospital, patients are currently identified using bracelets that are worn in the ward or on the patients leg in the admissions department. Patient identification at each stage of the provision of medical services allows for timely monitoring of the situation in the hospital departments, eliminating the possibility of errors in appointments. All this affects the quality of medical care for children.
GARBAGE IN MODERN PHARMACOTHERAPY (REVIEW OF LITERATURE)
Authors: Кудрявцева Н.М. , Телегина Г.Ф.
Published: August 2022

Несмотря на современные возможности химического синтеза лекарственных препаратов, лечение многих заболеваний предусматривают использование препаратов, основой для производства которых служат растительные препараты. Растение барвинок является источником алкалоидов, входящих в сосудистые и базовые цитостатические препараты. Он давно и хорошо изучен, но еще продолжаются исследования с целью снижения токсических осложнений и повышению селективности терапевтического воздействия.

Despite the modern possibilities of the chemical synthesis of drugs, the treatment of many diseases involves the use of drugs, the basis for the production of which are herbal preparations. The periwinkle plant is a source of alkaloids included in the vascular and basic cytostatic preparations. It has long been well studied, but research is still ongoing to reduce toxic complications and increase the selectivity of therapeutic effects.
CLINICAL CASE OF ACUTE LEUKEMIA IN A CHILD WITH THALASSEMIA
Authors: Боталова И.В. , Никонова О.Е. , Рыскаль О.В.
Published: August 2022

Введение. Авторы описывают талассемию как группу генетически детерминированных болезней крови и возможные сочетания ее с другими заболеваниями, приводят данные найденных ими литературных источников по обсуждаемой тематике.Клинический случай. У пациентки с 3 лет с была диагностирована наследственная гемолитическая анемия – малая форма β-тассемии, а в 6 лет ребенок госпитализирован с острым лимфобластным лейкозом. Течение острого лейкоза не потребовало дополнительной гемотрансфузионной нагрузки по сравнению с другими пациентами. Была получена полная клинико-гематологическая ремиссия.Заключение. В статье представлен редкий случай развития острого лейкоза у ребенка, которому ранее был установлен диагноз талассемии. Нетяжёлая форма наследственной гемолитической анемии позволяет успешно справляться с проявлениями цитопенического синдрома при проводимой противоопухолевой терапии. Вопрос о характере связи развития лейкоза у ребенка с талассемией обсуждается в литературе с различных позиций.
DIE TO SURVIVE
Authors: Дмитриенко О.В.
Published: August 2022

В научной статье рассмотрены подвиги замечательного хирурга из Челябинска Георгия Федоровича Синякова. Великая Отечественная война оставила неизгладимый след в истории России. Свой вклад в достижение победы сделали тысячи людей, кто-то сражался в бою, кто-то трудился в тылу, а кто-то спасал жизни. За 75 лет накопилось огромное количество материалов о заслугах советских военных, рабочих, ученых и врачей. Целью работы были поиск и обобщение информации о жизни, работе и достижениях Г.Ф. Синякова. Материалами исследования служили публикации, интервью с участниками Великой Отечественной войны, документы Челябинского Музея медицины.

The scientific article describes the exploits of the remarkable Chelyabinsk surgeon Georgy Sinyakov. The Great Patriotic War left an indelible mark on the history of Russia. Thousands of people made their contribution to the victory, some fought in battle, some worked in the rear, and some saved lives. For 75 years, a huge amount of material has accumulated about the merits of the Soviet military, workers, scientists and doctors. The purpose of the work was to search for and summarize information about the life, work and achievements of G. F. Sinyakov. The research materials were publications, interviews with participants of the Great Patriotic War, documents of the Chelyabinsk Museum of medicine.
A CASE OF PETROL (HYDROCARBON) PNEUMONIA IN A 2-YEAR-OLD CHILD
Authors: Галышева О.В. , Каримова И.П. , Синицына Е.В. , Шилова Т.В. , Сокол Е.В. , Куликовская О.В. , Фокин А.В. , Лещева Т.Ю. , Франц Д.А. , Просеков В.А.
Published: August 2022

Бензиновая (углеводородная) пневмония рассматривается как вариант липоидной экзогенной пневмонии, развивается при ингаляции или аспирации нефтепродуктов (в том числе бензина, керосина) и относится к редко встречающимся заболеваниям органов дыхания. Определенные затруднения вызывает диагностика данного состояния, учитывая отсутствие характерных изменений в анализах крови, данных объективного статуса, разнообразие картины при лучевой диагностике. Наиболее информативным методом исследования при данной нозологии является цитологическое исследование бронхоальвеолярного смыва и гистологическое исследование биоптата легочной ткани. В настоящее время, в связи с небольшим количеством наблюдений доказанного способа лечения не существует. Однако отмечается рост бензиновой пневмонии, в том числе и у детского населения. В статье рассмотрен клинический случай углеводородной пневмонии у ребенка.
Improvement of the early diagnostic system and complex treatment elderly aged victims with severe traumatic brain injury of postoperative infectious-inflammatory complications
Authors: Щербук Ю.А. , Мадай Д.Ю. , Щербук А.Ю. , Донсков В.В. , Черепанова Е.В. , Тюрин Р.В. , Лейко Д.В.
Published: August 2022

Цель работы - усовершенствование системы ранней диагностики и комплексного лечения пострадавших пожилого возраста с тяжелой черепно-мозговой травмой (ЧМТ) и послеоперационными инфекционно-воспалительных осложнениями. Проведено обследование и лечение 94 пострадавших пожилого возраста, оперированных по поводу тяжелой ЧМТ в лечебных учреждениях Санкт-Петербурга. Обследование при выявлении воспалительных осложнений осуществляли с момента подъема температуры, оно включало лабораторные, ультрасонографические, рентгенологические исследования, в том числе КТ. Проведенные комплексные меры позволили снизить тяжесть и длительность течения травматической болезни у пострадавших с послеоперационными воспалительными осложнениями, сократить средний койко-день стационарного лечения в нейрохирургическом отделении с 42±6 до 33±5 сут. Вероятность развития инфекционно-воспалительных осложнений со стороны легких возрастала независимо от возраста у большинства пострадавших. В то же время, воспалительные осложнения со стороны мочевыводящих путей значительно чаще развивались у мужчин пожилого возраста, страдающих гиперплазией предстательной железы с нарушением мочеиспускания, в результате длительного использования уретральных катетеров. Ранние комплексные диагностические исследования позволили своевременно выявить возникшие послеоперационные осложнения и начать адекватное лечение.

Improve the system of early diagnostic and complex treatment of postoperative infectious - inflammatory complications in victims of elderly ages with severe cranial injury. Medical institutions of Saint-Petersburg provided examination and treatment to 94 victims of elderly ages who were operated due to severe cranial injury. Examinations to identify inflammatory complications were provided from the body temperature rising and included laboratory tests, ultrasonography, X-Rays, Computer Tomography. The complex measures taken allowed to reduce severity and duration of postoperative inflammatory complications, cut the average bed-day hospital treatment from 42±6 days to 33±5 days in victims located in the neurosurgery department. Probability of infectious - inflammatory pulmonary complications development increases regardless of age. At the same time inflammatory urine tract complications most often occur among elderly age men who suffer from prostate hyperplasia and malfunction of the urination process after a long time of using intraurethral catheters. Early complex diagnostic examination allows the timely diagnosis of postoperative complications, and to begin the adequate treatment of victims.
Clinical significance of CIRS-G comorbid status assessment in patients with localized prostate cancer
Authors: Невирович Е.С.
Published: August 2022

У мужчин одним из чаще всего встречающихся онкологических заболеваний является рак предстательной железы. Страдают данной патологией в основном пациенты старшей возрастной группы. На сегодняшний день современная медицина располагает большим количеством методов радикального лечения рака предстательной железы с хорошими показателями выживаемости. Однако пациенты пожилого и старческого возраста довольно сложны в лечении хирургическим путем ввиду наличия коморбидности. Любая сопутствующая патология должна быть вовремя компенсирована в предоперационном периоде для достижения максимально возможных положительных клинических результатов после операции.

Among the male population, one of the most common cancers is prostate cancer. The predominant number of patients suffering from this pathology are patients of the older age group. Today, modern medicine has a large number of methods of radical treatment of prostate cancer with good survival rates. However, elderly and senile patients are quite difficult to treat surgically due to the presence of comorbidity. Any concomitant pathology should be compensated in time in the preoperative period in order to achieve the maximum possible positive clinical results after surgery.
Effect of combined diabetic retinopathy and cataract on instrumental functional activity of patients
Authors: Агарков Н.М. , Лев И.В. , Османов Р.Э.
Published: August 2022

Потенциальным фактором, снижающим в значительной степени инструментальную функциональную активность людей старшего возраста, выступает нарушение зрения вследствие возраст-ассоциированных болезней глаза - катаракты и диабетической ретинопатии, доминирующих в указанной возрастной когорте. Цель исследования - изучение инструментальной функциональной активности пациентов старших возрастных категорий с диабетической ретинопатией и катарактой. По специальному опроснику проведено анкетирование 115 человек 60- 74 лет с сочетанной катарактой и диабетической ретинопатией и 102 человек 60-74 лет без офтальмологических заболеваний на базе Тамбовского филиала МНТК «”Микрохирургия глаза” им. академика С.Н. Федорова». Установлено, что средний балл инструментальной функциональной активности у больных катарактой и диабетической ретинопатией был статистически значимо ниже, составляя 3,10±0,08 балла против 5,38±0,09 балла у людей без офтальмопатологии. Основными причинами, снижающими инструментальную функциональную активность у больных с нарушением зрения, являются проблемы с совершением различных покупок и пользованием общественным или личным транспортом. Факторный анализ подтвердил, что вклад этих причин в снижение инструментальной функциональной активности наивысший и составляет, соответственно, 0,876 и 0,708. Поэтому рекомендуется повысить инструментальную функциональную помощь пациентам с катарактой и диабетической ретинопатией в решении проблем пользования транспортом и с покупкой различных товаров.

A potential factor that significantly reduces the social activity of older people is visual impairment due to age-associated eye diseases - cataracts and diabetic retinopathy, which dominate in this age cohort. The aim of the study was to study the social activity of elderly patients with diabetic retinopathy and cataracts. According to a special questionnaire, 115 people 60-74 years old with combined cataract and diabetic retinopathy and 102 people 60-74 years old without ophthalmological diseases were questioned based on the Tambov branch of the MNTK «Academician S.N. Fedorov Eye Microsurgery». It was found that the average score of social activity in patients with cataract and diabetic retinopathy is statistically significantly lower, amounting to 3,10±0,08 points, versus 5,38±0,09 points in people without ophthalmopathology. The main reasons that reduce social activity in patients with visual impairment are problems with making various purchases and using public or personal transport. Factor analysis confirmed that the contribution of these reasons to the decrease in social activity is the highest and amounts to 0,876 and 0,708, respectively. Therefore, it is recommended to increase social assistance to patients with cataracts and diabetic retinopathy in solving the problems of using transport and purchasing various goods.
Perioperative hemostatic therapy in geriatric patients in urology
Authors: Солуянов М.Ю. , Кочеткова М.В. , Хабаров Д.В. , Демура А.Ю. , Сюткина И.П. , Смагин А.А.
Published: August 2022

Цель исследования - оценка эффективности использования транексамовой кислоты в профилактике интраоперационных геморрагических осложнений у пациентов геронтологического профиля с биполярной трансуретральной резекцией простаты (БТУРП). Пациенты методом конвертов были разделены на две группы. Пациентам 1-й группы (контрольная, n =42) не проводили инфузию транексамовой кислоты. Пациентам 2-й группы (основная, n =42) прединтраоперационно проводили инфузию транексамовой кислоты в дозе 2 мг/кг. Всем пациентам была выполнена БТУРП на эндоскопическом оборудовании по стандартной методике под спинальной анестезией. Сравнение групп проводили по следующим критериям: объём интраоперационной кровопотери, уровень эритроцитов, тромбоцитов и гемоглобина, показатели гемостаза, тромбоэластография до и после операции. Установлено, что периоперационное применение транексамовой кислоты позволило достоверно уменьшить объем кровопотери при БТУРП. Метод тромбоэластографии за счет количественно-качественных характеристик способен выявить, почему достигается эффективность применения ингибитора фибринолиза.

The aim of the study was to evaluate the effectiveness of the use of tranexamic acid in the prevention of intraoperative hemorrhagic complications in geriatric patients with bioply transurethral resection of the prostate (BTURP). The patients were divided into 2 groups by the envelope method. Patients of the first group (control group, n =42) did not receive tranexamic acid infusion. Patients of the second group (main group, n =42) received pre-intraoperative infusion of tranexamic acid at a dose of 2 mg/kg. All patients underwent BTURP on endoscopic equipment according to the standard technique under spinal anesthesia. The groups were compared according to the following criteria: the volume of intraoperative blood loss, the level of erythrocytes, platelets and hemoglobin, indicators of hemostasis, thromboelastography before and after surgery. It was established that the perioperative use of tranexamic acid allowed to significantly reduce the volume of blood loss in BTURP. The method of thromboelastography, due to quantitative and qualitative characteristics, is able to assess how the effectiveness of the use of a fibrinolysis inhibitor is achieved.
THE EFFECT OF INVESTMENT OPPORTUNITY SET, INSTITUTIONAL OWNERSHIP, AND COMPANY SIZE ON THE QUALITY OF EARNINGS ON COMPANIES LISTED ON THE INDONESIA STOCK EXCHANGE (PERIOD 2018-2020)
Authors: Hidayat Imam , Utami Rika Dwi
Published: August 2022

This study aims to determine the effect of investment opportunity set, institutional ownership, and company size on earning quality. Of the 52 companies in the consumption sector, there are 22 sample companies and will be analyzed from 2018 to 2020. This type of research uses a quantitative approach with the panel data regression method, which is processed with EViews version 12. The result shows that investment opportunity set and institutional ownership has no positive and significant effect on earnings quality. Firm size has a positive effect and significant effect on earnings quality.
EFFECT OF EXECUTIVE COMPENSATION AND BOARD GOVERNANCEON QUALITY OF SUSTAINABILITY AND FINANCIAL REPORTING ON FINANCIAL INSTITUTIONS ON IDX
Authors: Ridaryanto Petrus , Marsudi Almatius
Published: August 2022

This study will examine the impact of executive compensation and board governance on the level of investment in sustainability practices and sustainability reporting quality and examine the relationship between sustainability reporting quality and financial reporting quality in financial services companies listed on the Indonesia Stock Exchange (IDX). The purpose of this study was to examine the effect of executive compensation and board governance on the quality of sustainability reporting in State-Owned Enterprises (BUMN) and financial institutions on the IDX. Observations will be made for the 2015-2019 period. The number of state-owned companies is around 120 companies and financial institutions are 95 companies. The total sample companies are 215 sample companies. The quality of sustainability reporting is measured by content analysis. This study will analyze all hypotheses using multiple regression. The results show that executive compensation and board governance have no effect on the quality of the sustainability report, and the quality of the sustainability report has a positive effect on the quality of financial reports
VALUE OF PANAI’ ON SOCIAL CAPITAL CONCEPTCULTURAL STUDY IN SOUTH SULAWESI
Authors: Usman Silviyana , Tenriwaru Tenriwaru
Published: August 2022

This study aims to determine how to determine the value of panai' in the Bugis-Makassar ethnic community in South Sulawesi. This study uses a qualitative method with an ethnographic approach with narrative analysis techniques. The ethnographic approach is a qualitative research strategy in which the researcher investigates culture in the natural environment for a sufficiently long period of time to collect data. The data of this study were obtained from primary and secondary data. The results showed that to determine the amount of panai' there were several factors, namely social status, education level, physical factors of the prospective bride, food prices and social capital. The position of the panai' money is very burdensome for the men if the panai' money requested is too expensive. Panai money should be a form of positive attitude shown by men who have to work hard to provide panai money in order to woo the desired lover. In accounting, transparency and accountability of panai' money is very necessary for both candidates to maintain trust because the amount of money given must be known by the nuclear family of the prospective bride and groom and in its management it must be used according to its function.