bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of a Virtual Noncalcium Dual-Energy CT Application in the Detection of Bone Marrow Edema in Peripheral Osteomyelitis
Authors: Yan Yet Yen , Ouellette Hugue A. , Saththianathan Mayuran , Munk Peter L. , Mallinson Paul I. , Sheikh Adnan
Published: January 2022

Purpose: To determine the sensitivity and specificity of dual-energy CT (DECT) virtual noncalcium images (VNCa) with bone and soft tissue reconstructions in the diagnosis of osteomyelitis. Materials & Methods: Between December 1, 2014 to December 1, 2020, 91 patients who had 99 DECT performed for a clinical indication of osteomyelitis with corresponding MRI, triphasic bone scan and/or white blood cell scintigraphy with CT/SPECT performed either 2 weeks before or 1 month after the DECT were retrospectively identified. The presence or absence of osteomyelitis was established using a second imaging test, bone biopsy or surgery. Two radiologists interpreted VNCa images alone and with bone and soft tissue reconstructions for osteomyelitis. Fleiss k statistics was used to assess inter-level agreement. Results: Osteomyelitis was present in 26 cases (26.2%), of which 4 cases (4%) had co-existing septic arthritis. DECT was performed at the following sites: ankle/foot (n = 59), calf (n = 12), knee (n = 3), thigh (n = 7), hip (n = 9), pelvis (n = 6), wrist/hand (n = 1), and shoulder (n = 2). Sensitivity with VNCa images alone was 53.8% and 73.1% and specificity was 84.9% and 71.2%. Sensitivity with VNCa images and bone and soft tissue reconstructions was 80.8% and 80.8% and specificity was 80.8% and 72.6%. Interobserver agreement was 76.7% (76 of 99 cases), for VNCa images alone (k = .487), and 66.7% (66 of 99 patients) for bone and soft tissue reconstructions with VNCa images together (k = .390). Conclusion: When VNCa images were combined with bone and soft tissue reconstructions, there is improved sensitivity in the diagnosis of osteomyelitis.
The Growth of Palliative Practice and End of Life Care in an Academic Teaching Intensive Care Unit
Authors: King Daniel , Schockett Erica , Rizvi Ghazi , Fischer Daniel , Amdur Richard , Benjenk Ivy , Yamane David , DelPrete Benjamin , Davison Danielle , Seneff Michael
Published: January 2022

Objective

Dying in the intensive care unit (ICU) has changed over the last twenty years due to increased utilization of palliative care. We sought to examine how palliative medicine (PM) integration into critical care medicine has changed outcomes in end of life including the utilization of do not resuscitate (no cardiopulmonary resuscitation but continue treatment) and comfort care orders (No resuscitation, only comfort medication). Design: Retrospective observational review of critical care patients who died during admission between two decades, 2008 to 09 and 2018 to 19. Setting: Single urban tertiary care academic medical center in Washington, D.C. Patients: Adult patients who were treated in any ICU during the admission which they died.

Interventions and Measurements

We sought to measure PM involvement across the two decades and its association with end of life care including do not resuscitate (DNR) and comfort care (CC) orders. Main Results: 571 cases were analyzed. Mean age was 65 ± 15, 46% were female. In univariate analysis significantly more patients received PM in 2018 to 19 (40% vs. 27%, p = .002). DNR status increased significantly over time (74% to 84%, p = .002) and was significantly more common in patients who were receiving PM (96% vs. 72%, p < 0.001). CC also increased over time (56% to 70%, p = <0.001), and was more common in PM patients (87% vs. 53%, p < 0.001). Death in the ICU decreased significantly over time (94% to 86%, p = .002) and was significantly lower in PM patients (76% vs. 96%, p < 0.001). The adjusted odds of getting CC for those receiving versus those not receiving PM were 14.51 (5.49-38.36, p < 0.001) in 2008 to 09 versus 3.89 (2.27-6.68, p < 0.001) in 2018 to 19. Conclusion: PM involvement increased significantly across a decade in our ICU and was significantly associated with incidence of DNR and CC orders as well as the decreased incidence of dying in the ICU. The increase in DNR and CC orders independent of PM over the past decade reflect intensivists delivering PM services.
America’s First Memorial Honoring Survivors of Sexual Violence
Authors: Sardina Alexa , Fox Nicole
Published: January 2022

Over the past two decades, America taken part of a broader global trend of “memorial mania” in which memorials dedicated to remembering injustice have exploded into public space. Memorials that facilitate the centering of marginalized narratives of violence hold significant power for social change. This article focuses on one such space: The Survivors Memorial in Minneapolis, Minnesota. The Survivors Memorial opened in October 2020 and is the first public memorial honoring survivors of sexual violence. Despite the progress of the anti-rape and feminist movements as well as a variety of legal interventions designed to address sexual violence and empower, many survivors are left without a sense of justice or institutional or community recognition. Drawing on 21 in-depth, qualitative interviews with individuals involved in all aspects of the memorial project, this article documents how one community mobilized to create a space for survivors whose voices are often overlooked, disbelieved and silenced by the criminal justice system, practitioners, and communities. In focusing on how participants narrate the significance and meaning of the Survivors Memorial, this article uncovers how social, political, and local circumstances coalesced to make the Memorial possible. These factors include local leadership, the prevalence of sexual violence, the unique structure of the Minneapolis park structure, and the rise of the #MeToo movement. Interviews illuminate that participants worked to intentionally construct the Memorial as an accessible and visible space that centers on providing all sexual violence survivors with public acknowledgment of their experiences, while simultaneously engaging community members in dialogs about sexual violence, ultimately, laying the foundation for sexual violence prevention efforts.
Employee Incentive ESOPs: An Equity Tool to Promote Engagement and Performance
Authors: Gilmore Trevor J.
Published: January 2022

Employee stock ownership plans (ESOPs) are experiencing renewed interest in America. In recent years, new ESOP formation was largely driven by the aging of the Baby Boomer generation (widely defined as those born between 1946 and 1964), and their desire to liquify their ownership in closely held businesses while rewarding their employees. There are other new forces driving this trend—the quest for equitable solutions for the growing divide between have and have-nots, the need for employers to retain and reward employees in a competitive talent market, and succession planning. In this article, I will discuss how an Employee Incentive ESOP can be used to promote performance and engagement in a broad-based manner.
Response to Linda Woodhead's Paper: ‘Truth and Deceit in Institutions’
Authors: Bone Amra
Published: January 2022

At the 2021 conference of the Society for the Study of Christian Ethics, Linda Woodhead presented a paper entitled ‘Truth and Deceit in Institutions’. Amra Bone was then invited to deliver a response to this paper drawing on her knowledge of Islamic traditions and culture. This article is her response. The article highlights the importance the Qur’anic scripture gives to justice and neither distorting nor refusing to give testimony. It then briefly explores the Arabic term Kufr found in the Qur’an. Whilst more commonly interpreted to mean disbelief, this term literally means hiding or covering up truth. Dishonesty can therefore be equated to disbelief which makes it a very serious matter for Muslims. Therefore ethics determine that the road to greater institutional honesty must be adopted. In Islamic Law the end does not justify the means; rather the outcome rests with God alone and the responsibility given to men and women is to act honestly and ethically. For any institution or society to develop positively, every individual must play their part and take this responsibility seriously and not to rely on a few courageous individuals.
Energy and exergy analysis of a downstream single-row air washer at different droplet diameters for air cooling application
Authors: Huang Minhua , Wang Haiqiao , Tian Feng , Huang Junxin , Chen Shiqiang , Jiang Jiachuan , Liu Ruihong
Published: January 2022

This study proposes a downstream single-row air washer for air cooling. The theoretical energy and exergy balance models were established at different droplet diameters and verified by the experimental data. Based on the abovementioned theoretical relationship, the single performance indicator of heat exchange efficiency (HEE) and exergy efficiency was quantitatively analyzed; a comprehensive analysis method of two indicators was proposed, combining HEE and exergy efficiency, and a numerical simulation was carried out. Results show that the smaller the droplet diameter and the larger the water–air ratio, the lower the dry-bulb temperature of the outlet air and the higher the HEE and exergy flux destruction. When the droplet diameter is less than 440 μm, the droplet diameter does not affect exergy efficiency and dry-bulb temperature. When the droplet diameter is larger than 440 μm, the droplet diameter is positively correlated with the air outlet dry-bulb temperature and exergy efficiency; in contrast, the water–gas ratio is negatively correlated with the air outlet dry-bulb temperature. An engineering case reveals that when the air outlet temperature is less than 34°C, the critical water–gas ratio can be set as 2.6 (mass ratio). At this time, the HEE is more than 90%, the exergy efficiency is more than 60%, and the critical value of droplet diameter is 440 μm. The research results provide an essential theoretical basis for the optimization of engineering design calculation.
Important powertrain dynamics for developing models for control of connected and automated electrified vehicles
Authors: Hemmati Sadra , Yadav Rajeshwar , Surresh Kaushik , Robinette Darrell , Shahbakhti Mahdi
Published: January 2022

Connected and Automated Vehicles (CAV) technology presents significant opportunities for energy saving in the transportation sector. CAV technology forecasts vehicle and powertrain power needs under various terrain, ambient, and traffic conditions. Integration of the CAV technology in Hybrid Electric Vehicles (HEVs) provides the opportunity for optimal vehicle operation. Indeed, Hybrid Electric Vehicle powertrains present high degrees of flexibility and possibility for choosing optimum powertrain modes based on the predicted traction power needs. In modeling complex CAV powertrain dynamics, the modeler needs to consider short-time scale powertrain dynamics, such as engine transients, and hysteresis of mode-switching for a multi-mode HEV. Therefore, the powertrain dynamics essential for developing powertrain controllers for a class of connected HEVs is presented. To this end, control-oriented powertrain dynamic models for a test vehicle consisting of full electric, hybrid, and conventional engine operating modes are developed. The resulting powertrain model can forecast vehicle traction torque and energy consumption for the specified prediction horizon of the test vehicle. The model considers different operating modes and associated energy penalty terms for mode switching. Thus, the vehicle controller can determine the optimum powertrain mode, torque, and speed for forecasted vehicle operation via utilizing connectivity data. The powertrain model is validated against the experimental data and shows prediction error of less than 5% for predicting vehicle energy consumption. The model is used to create energy penalty maps that can be used for CAV control, for example fuel penalty map for engine torque changes (10–40 Nm) at each engine speed. The results of model-based optimization show optimum switching delays ranging from 0.4 to 1.4 s to avoid hysteresis in mode switching.
Effects of plate contouring quality on the biomechanical performance of high tibial osteotomy fixation: A parametric finite element study
Authors: Hayatbakhsh Zahra , Farahmand Farzam
Published: January 2022

Locking plates have threaded holes, in which threaded-head screws are affixed. Hence, they do not need to be in intimate contact with underlying bone to provide fixation. There are, however, reports that a large distance between the plate and the bone might cause clinical complications such as delayed union or nonunion, screw pull out, and screw and plate breakage. Considering the diversity in the capabilities and costs of different plate customization techniques, the purpose of this study was to investigate the effect of the plate contouring quality on the biomechanical performance of high tibial osteotomy (HTO) fixation. A finite element model of proximal tibia was developed in Abaqus, using the QCT data of a cadaver. The model was then subjected to open-wedge HTO (correction angle 12°) with TomoFix plate fixation. The sagittal curvature of the plate was changed parametrically to provide certain levels of geometrical fit, and the biomechanical performance parameters of fixation were assessed. Results indicated 5%, 9% and 38% increase in the stiffness of the construct, and the von Mises stress in the plate and locking screw just above the osteotomy site, respectively, when the level of fit of plate changed from 0% (initial non-contoured initial shape) to 100% (fully adapted shape). The same change decreased the pressure at the lateral hinge of the osteotomy by 61%, and the mean of the tensile stress on the screw shaft by 12%. It was concluded that the level of fit has conflicting effects on the biomechanical parameters of the HTO fixation system, that is, the structural stiffness, the pressure at the lateral hinge, the stresses in the plate and screws, and the pull out resistance of the screws. In particular, for HTO patients with high quality bone, the optimal level of fit should provide a tradeoff between these parameters.
Validation of wearable inertial sensor-based gait analysis system for measurement of spatiotemporal parameters and lower extremity joint kinematics in sagittal plane
Authors: Patel Gunjan , Mullerpatan Rajani , Agarwal Bela , Shetty Triveni , Ojha Rajdeep , Shaikh-Mohammed Javeed , Sujatha S
Published: January 2022

Wearable inertial sensor-based motion analysis systems are promising alternatives to standard camera-based motion capture systems for the measurement of gait parameters and joint kinematics. These wearable sensors, unlike camera-based gold standard systems, find usefulness in outdoor natural environment along with confined indoor laboratory-based environment due to miniature size and wireless data transmission. This study reports validation of our developed (i-Sens) wearable motion analysis system against standard motion capture system. Gait analysis was performed at self-selected speed on non-disabled volunteers in indoor ( n = 15) and outdoor ( n = 8) environments. Two i-Sens units were placed at the level of knee and hip along with passive markers (for indoor study only) for simultaneous 3D motion capture using a motion capture system. Mean absolute percentage error (MAPE) was computed for spatiotemporal parameters from the i-Sens system versus the motion capture system as a true reference. Mean and standard deviation of kinematic data for a gait cycle were plotted for both systems against normative data. Joint kinematics data were analyzed to compute the root mean squared error (RMSE) and Pearson’s correlation coefficient. Kinematic plots indicate a high degree of accuracy of the i-Sens system with the reference system. Excellent positive correlation was observed between the two systems in terms of hip and knee joint angles (Indoor: hip 3.98° ± 1.03°, knee 6.48° ± 1.91°, Outdoor: hip 3.94° ± 0.78°, knee 5.82° ± 0.99°) with low RMSE. Reliability characteristics (defined using standard statistical thresholds of MAPE) of stride length, cadence, walking speed in both outdoor and indoor environment were well within the “Good” category. The i-Sens system has emerged as a potentially cost-effective, valid, accurate, and reliable alternative to expensive, standard motion capture systems for gait analysis. Further clinical trials using the i-Sens system are warranted on participants across different age groups.
The moderating role of informal economy on financial development induced ekc hypothesis in turkey
Authors: Memduh Eren Baris , Katircioglu Salih , Gokmenoglu Korhan K.
Published: January 2022

This study conducts an empirical investigation about the moderating role of the informal economy on Turkey's environmental performance by employing advanced econometric techniques that account numerous structural breaks in series. In this extent, we created three interaction variables by captivating the impact of informal economic activities on CO2 emissions through income, energy use, and financial sector development. Besides, we built a main effect model without the interaction variables to assess the direct effects of our variables on global environmental degradation. The outcomes of the carried analyses produced supporting evidence toward the confirmation of the Environmental Kuznets Curve (EKC) assumption. Obtained findings shown that energy use, financial development and the informal economy in Turkey transmit a deteriorating impact on environmental well-being. Furthermore, the moderating role of the informal economy was found to be statistically significant factor in terms of both economic and environmental efficiency.
Vitamin D levels in Greek patients with systemic lupus erythematosus
Authors: Athanassiou Lambros , Kostoglou-Athanassiou Ifigenia , Tsakiridis Pavlos , Devetzi Eirini , Mavroudi Maria , Fytas Pantelis , Koutsilieris Michael , Athanassiou Panagiotis
Published: January 2022

Objectives

Vitamin D deficiency has been observed in autoimmune rheumatic diseases, such as rheumatoid arthritis. The aim was to study vitamin D in patients with systemic lupus erythematosus (SLE) and its relationship with disease activity.

Methods

In a cohort of 45 patients with SLE, 41 females and 4 males, aged 47.07 ± 2.17 years (mean ± SEM), and range = 21–79 years, 25(OH)D3 levels were determined by electrochemiluminescence. C3 and C4 levels were also analyzed. SLE disease activity was estimated by SLEDAI-2K. Observations were also performed in a control group matched for age and sex.

Results

In this cohort of SLE patients, 25(OH)D3 levels were 40.36 ± 2.41 nmol/L (mean ± SEM) as opposed to 60.98 ± 4.28 nmol/L in the control group ( p < 0.001, Student’s t test). Vitamin D levels were related to C3 ( p < 0.001, linear regression analysis), correlation coefficient 0.106, r2 = 0.011, and C4 ( p < 0.001); correlation coefficient 0.316 and r2 = 0.100; and inversely related to disease activity ( p < 0.001), correlation coefficient −0.572 and r2 = 0.327. 25(OH)D3 levels were 17.73 ± 1.20 nmol/L and 12.24 ± 0.93 nmol/L, in the groups without and with renal involvement, respectively ( p = 0.001, Student’s t test).

Conclusions

Vitamin D levels are low in SLE patients and are inversely related to disease activity. Routine screening for vitamin D levels should be performed in SLE patients.
Evaluation of Kraft pulp yield and syringyl/guaiacyl ratio from standing trees (Eucalyptus camaldulensis, E. urophylla, Leucaena leucocephala and Casuarina junghuhniana) using portable near infrared spectroscopy
Authors: Ramadevi Payyavula , Kamalakannan Rathinam , Suraj Ganapathy P , V Hegde Deepak , Varghese Mohan
Published: January 2022

Measurement of pulpwood traits from a standing tree has considerable advantage when screening large populations for tree selection. It reduces time and also eliminates requirements of transport, powdering, and storing the sample. This study describes estimation of Kraft pulp yield (KPY) in Eucalyptus camaldulensis, E. urophylla, Leucaena leucocephala, and Casuarina junghuhniana by portable NIR spectroscopy of standing trees. Calibration models were developed for KPY estimation using portable NIR spectroscopy for the four species, along with a calibration model for syringyl/guaiacyl (S/G) ratio in E. camaldulensis. The calibration models for KPY showed R2 values ranging from 0.93 ( E. camaldulensis) to 0.83 ( L. leucocephala), and 0.95 for S/G ratio. The developed calibration models for E. camaldulensis and L. leucocephala were compared with laboratory NIR models, and a variation of <±2.0% was found between both methods. The models were validated by both external and cross validation which showed <2.0% RMSEP (root mean square error of prediction) and <2.0% RMECV (root mean square error of cross validation) in external and cross validations, respectively.
Through the Looking Glass: How the COVID-19 Pandemic Changed International Branch Campuses’ Academic Experience and Home Campus Relationship
Authors: Merola Rachael H. , Coelen Robert J. , Hofman W. H. A. , Jansen Ellen P. W. A.
Published: January 2022

This study examines how the COVID-19 pandemic has impacted the academic experience at international branch campuses (IBCs) and has changed the relationship between the IBC and the home campus. Semi-structured interviews with 26 leaders, academic staff, and students at seven IBCs in Malaysia revealed that the COVID-19 pandemic has changed the experience at IBCs in unique ways, including collaboration and communication with the home campus; increasing campus-specific resources for student wellbeing; and playing a larger role in student enrollment, recruitment, and mobility initiatives. Findings provide useful insights for higher education institutions (HEIs) engaged in transnational education (TNE).
Unpacking Transnational Social Capital and its Effects: Insights from an International Study Experience in Belgium
Authors: Holvoet Nathalie , Dewachter Sara
Published: January 2022

This paper studies (trans)national social capital gained through an international study experience in Belgium. Drawing upon a multi-method alumni study, we explore different types of (inter)national networks of male and female graduates, the extent to which different networks remained after graduation as well as effects on personal and professional development and organizational performance. Findings show that graduates have particularly gained networks with non-co-nationals which evolve from bridging relations at the outset to bonding relations while particularly networks with the host population remain limited. After returning home, bonding social interaction relations remain most important, irrespective of the nationality of the graduates, whereas information sharing and collaboration networks survive better among co-nationals, particularly when these are triggered through national alumni chapters. Our study finds network effects on individual's intercultural skills, knowledge and attitudes, their professional career and organizational performance, with intercultural gains being particularly high for networks with non-co-nationals from other continents.
Is music listening an effective intervention for reducing anxiety? A systematic review and meta-analysis of controlled studies
Authors: Harney Cristina , Johnson Judith , Bailes Freya , Havelka Jelena
Published: January 2022

Anxiety is the most commonly diagnosed mental health disorder in the EU and 18% of the US population experiences an anxiety disorder at any one time. However, only 20% of individuals experiencing anxiety receive a formally administered intervention, highlighting a need for evidence-based interventions that can be self-administered. Music listening can be flexibly self-administered and may be useful for anxiety reduction, but further evidence is needed. The current paper addressed this by conducting the first systematic review and meta-analysis of controlled studies testing music listening interventions for naturally occurring state anxiety. A protocol was registered on PROSPERO ID: CRD42018104308. Searches were carried out of the Cochrane Library, Ovid MEDLINE, PsycINFO, Embase, Web of Science and CINAHL databases, yielding 6208 records. After screening for eligibility, 24 controlled studies were included in the review and 21 were included in the meta-analysis. Results of the meta-analyses showed that music listening had an overall significant large effect on alleviating anxiety ( d = −0.77 [95% CI = −1.26, −0.28], k = 21). It was concluded that music listening is effective for reducing anxiety in a range of groups. Further research should focus on clinical groups with diagnosed mental health problems.
Phlegmonous gastritis in 2 yearling horses
Authors: Engiles Julie B. , Uzal Francisco A. , Navarro Mauricio A. , Reef Virginia B. , Bender Susan J.
Published: January 2022

Phlegmonous gastritis was diagnosed in 2 yearling fillies that were presented with a 1-wk history of fever, lethargy, and hypoproteinemia, associated with a previous diagnosis of equine proliferative enteropathy based on clinical signs and PCR assay detection of Lawsonia intracellularis in fecal samples. Abdominal ultrasound revealed enlargement of the stomach and expansion of its submucosal layer with hypoechoic fluid, as well as thickened hypomotile small intestinal segments. Given the poor prognosis and poor response to treatment, both horses were euthanized, one on the day of presentation and the other after 3 wk of intensive medical management including a combination of antimicrobials, analgesics, and intravenous colloids. At autopsy, acute mural gastritis characterized by severe submucosal edema with suppurative inflammation (i.e., phlegmonous gastritis) and necroulcerative enteritis compatible with the necrotizing form of equine proliferative enteropathy were identified in both horses. The gastric inflammation was associated with thrombosis and mixed bacterial populations, including Clostridium perfringens, that were confined to the submucosa without evidence of mucosal involvement; toxin genes compatible with C. perfringens type C were identified in one case. Human phlegmonous gastritis is an uncommon, often-fatal pyogenic infection that is often associated with mucosal injury, bacteremia, or immunocompromise. Our finding of this unusual gastric lesion in 2 horses with similar signalment, clinical disease, and spectrum of postmortem lesions suggests a similar etiopathogenesis that possibly involves local, regional, or distant hematogenous origin, and should be considered a potential complication of gastrointestinal mucosal compromise in horses.
Numerical investigation of sensing and energy harvesting performance of 0-3 and triply periodic minimal surface-based K0.475Na0.475Li0.05(Nb0.92Ta0.05Sb0.03)O3 and polyethylene piezocomposite: A comparative study
Authors: Karmakar Saptarshi , Kiran Raj , Vaish Rahul , Chauhan Vishal Singh
Published: January 2022

The present paper is devoted to conducting a comparative study on the sensing and energy harvesting performance of a 0-3 and triply periodic minimal surface (TPMS)-based piezocomposite with [Formula: see text] ( KNLNTS) material as piezoelectric inclusions and polyethylene as the matrix material. Different types of TPMS are reported in literature like Neovius, Fischer-Koch S, Schwarz CLP, Schoen Gyroid, Schoen IWP, Schwarz Primitive, etc. In the present study, Schwarz primitive TPMS is considered. Representative volume elements (RVEs) with four different volume fractions are generated and the finite element simulations are performed to compute the effective elastic and piezoelectric properties. The homogenization technique is used to calculate the effective properties. The calculated values of the effective properties are further used to calculate the sensing voltage between the electrodes and harvested power across the resistance. The effective elastic and piezoelectric properties increase with an increase in volume fraction of the piezoelectric inclusions resulting in a higher sensing voltage and power. Significant improvement in the effective elastic and piezoelectric properties of TPMS-based piezocomposite was observed. TPMS-based piezocomposite exhibited superior performance as compared to their 0-3 counterparts.
Uncertainty analysis of galloping based piezoelectric energy harvester system using polynomial neural network
Authors: Dash Rakesha Chandra , Sharma Narayan , Maiti Dipak Kumar , Singh Bhrigu Nath
Published: January 2022

This paper deals with the impact of uncertain input parameters on the electrical power generation of galloping-based piezoelectric energy harvester (GPEH). A distributed parameter model for the system is derived and solved by using Newmark beta numerical integration technique. Nonlinear systems tend to behave in a completely different manner in response to a slight change in input parameters. Due to the complex manufacturing process and various technical defects, randomness in system properties is inevitable. Owing to the presence of randomness within the system parameters, the actual power output differs from the expected one. Therefore, stochastic analysis is performed considering uncertainty in aerodynamic, mechanical, and electrical parameters. A polynomial neural network (PNN) based surrogate model is used to analyze the stochastic power output. A sensitivity analysis is conducted and highly influenced parameters to the electric power output are identified. The accuracy and adaptability of the PNN model are established by comparing the results with Monte Carlo simulation (MCS). Further, the stochastic analyses of power output are performed for various degrees of randomness and wind velocities. The obtained results showed that the influence of the electromechanical coefficient on power output is more compared to other parameters.
Effects of Camera Placement on Undergraduates’ Peer Teaching Reflection
Authors: Buonviri Nathan O. , Paney Andrew S.
Published: January 2022

We investigated whether camera placement affects peer teachers’ focus of attention during reflection. Preservice music teachers ( N = 14) reflected on peer teaching videos that had been recorded simultaneously from a head-mounted camera and a tripod-mounted camera at the back of the classroom. Participants completed the teaching reflection cycle twice, providing their observation comments in response to open-ended prompts. Responses were coded, with a single sentence as the unit of analysis, and a three-way repeated measures analysis of variance (ANOVA) revealed a significant difference in comment frequencies according to comment type (student-focused or teacher-focused) but not according to camera placement or trial. Our results corroborate previous research indicating that undergraduate peer teachers focus more on themselves than on their peers, and suggest that placing the camera in a position that shows the students, rather than the teacher, does not seem to affect this tendency. We discuss the implications for peer teaching experiences in teacher education courses.
Sinonasal Hamartomas: From Nasal Chondromesenchymal Hamartoma to Respiratory Epithelial Adenomatoid Hamartoma. Report of six Cases and Review of the Literature
Authors: Li Rongying , Saluja Karan , Lin Mei , Hu Zhihong , Cai Zhenjian , Zhu Hui
Published: January 2022

Sinonasal hamartomas are uncommon lesions of nasal and sinus cavities. Based on indigenous cellular components and characteristic histologic features, they are further classified into four entities: respiratory epithelial adenomatoid hamartoma (REAH), seromucinous hamartoma (SH), chondro-osseous and respiratory epithelial hamartoma (CORE), and nasal chondromesenchymal hamartoma (NCH). REAH, SH, and CORE are seen in adult patients, while NCH predominantly occurs in newborns and infants. Morphologically REAH and SH are composed of respiratory epithelium and seromucinous glands, CORE is related to REAH but with additional feature of chondroid and/or osseous tissue, and NCH is composed of chondroid and stromal elements but devoid of epithelial component. All four lesions can present as sinonasal mass lesions and with associated obstructive symptoms. Given the rarity of these lesions, diagnosis can be challenging, especially in unusual clinical scenario. In this study, we report six cases of sinonasal hamartoma, including one case of NCH, one case of CORE, two cases of SH, and two cases of REAH. All cases were from adult patients including four men and two women. We also review the literature of the clinical and pathologic features of these rare lesions.
Risk Factors for the Diagnosis of Colorectal Cancer
Authors: Lewandowska Anna , Rudzki Grzegorz , Lewandowski Tomasz , Stryjkowska-Góra Aleksandra , Rudzki Sławomir
Published: January 2022

Background

Colorectal cancer defined as cancer of the colon or rectum, is the third most frequently diagnosed cancer in men and the second in women, and, according to the World Health Organization database GLOBOCAN, it accounts for nearly 1.4 million new cases annually worldwide. The occurrence of colorectal cancer is associated with nonmodifiable risk factors, including age and hereditary factors, as well as with modifiable environmental and lifestyle factors.

Methods

The study included 800 patients, 400 diagnosed with colorectal cancer and 400 within the control group, who gave their written informed consent to participate in the study. Patients with cancer other than colorectal cancer were randomly selected for control group I, and patients with no cancer diagnosis were selected for control group II. The method used was a case-control study – an observational and analytical study with a control group, conducted among patients of the Clinical Oncology Centre and the Provincial Hospital in the years 2019–2020. The study comparing the exposure was carried out in a group of people who developed the endpoint, that is colorectal cancer, with the exposure in a well-matched group of controls who did not reach the endpoint. Assessment of activity and BMI was used according to WHO recommendations, as well as the expert system. The data were tested for the distribution and the homogeneity of variance was validated before applying the parameter tests. Comparison of quantitative variables between groups was performed using ANOVA.

Results

The mean age of the patients was 64.53 ± 8.86 years, of the control group I – 59.64 ± 9.33 and the control group II – 57.5 (7.83). There was a strong positive association between the incidence of ulcerative colitis and the risk of colorectal cancer ( P < .01). Among obese subjects, the risk of developing colorectal cancer was 1.27 (95% CI, 1.06–1.53) compared with nonobese subjects. A strong positive relationship was found between low physical activity converted to metabolic equivalent of MET effort per week and the risk of colorectal cancer ( P < .001). The relative risk for current smokers was 2.17 (95% CI 1.79–2.66). There was an association between higher fat consumption and higher red meat consumption and the risk of developing colorectal cancer ( P < .01).

Conclusions

Obesity, low physical activity, active and passive smoking and high salt and red meat consumption have been associated with an increased risk of colorectal cancer. These findings provide further evidence of the importance of maintaining a healthy lifestyle.
Immunogenicity of the COVID-19 Two-Vaccination Series Among Hematologic Malignancies: Report of Three Cases of Breakthrough Infection
Authors: Pasikhova Yanina , Morrison Austin R. , Katzman Ju Hee , Syed Misbahuddin
Published: January 2022

Data is limited on the immunogenicity of the COVID-19 two-vaccination series among patients with hematologic malignancies and current guidelines do not recommend routine monitoring for post-vaccine antibodies. However, we describe three patients who developed severe or critical COVID-19 infections six months after vaccination. This highlights the importance of routine testing of COVID-19 IgG Spike, semi-quantitative antibodies post-vaccination, particularly among immunocompromised patients.
Vorapaxar for Prevention of Major Adverse Cardiovascular and Limb Events in Peripheral Artery Disease
Authors: Morrison Justin T. , Govsyeyev Nicholas , Hess Connie N. , Bonaca Marc P.
Published: January 2022

Peripheral artery disease (PAD) is a severe manifestation of atherosclerosis. Patients with PAD are at heightened risk for atherothrombotic complications, including myocardial infarction and stroke (MACE); however, there is also an equal or greater risk of major adverse limb events (MALE), such as acute limb ischemia (ALI) and major amputation. Therefore, there is a need for effective medical therapies to reduce the risk of both MACE and MALE. Recent trials have demonstrated the role of thrombin inhibition in reducing the risk of MACE and MALE in PAD patients. One such medical therapy, vorapaxar, is a potent inhibitor of protease activated receptor-1 which mediates the cellular effects of thrombin. Vorapaxar, used in addition to aspirin, has demonstrated robust reductions in MACE and MALE in PAD patients. In this article, we provide a contemporary review of the current state of PAD and the role of antithrombotic medications in the treatment of PAD, as well as the current clinical data on vorapaxar and strategies to integrate vorapaxar into contemporary medical management of peripheral artery disease.
A Review of Pulmonary Arterial Hypertension Treatment in Extracorporeal Membrane Oxygenation: A Case Series of Adult Patients
Authors: Torbic Heather , Hohlfelder Benjamin , Krishnan Sudhir , Tonelli Adriano R.
Published: January 2022

Background:

Little data is published describing the use of medications prescribed for pulmonary arterial hypertension (PAH) in patients receiving extracorporeal membrane oxygenation (ECMO). Even though many patients with PAH may require ECMO as a bridge to transplant or recovery, little is reported regarding the use of PAH medications in this setting.

Methods:

This retrospective case series summarizes the clinical experience of 8 patients with PAH receiving ECMO and reviews medication management in the setting of ECMO.

Results:

Eight PAH patients, 5 of whom were female, ranging in age from 21 to 61 years old, were initiated on ECMO. Veno-arterial (VA) ECMO was used in 4 patients, veno-venous (VV) ECMO and hybrid ECMO configurations in 2 patients respectively. Common indications for ECMO included cardiogenic shock, bridge to transplant, and cardiac arrest. All patients were on intravenous (IV) prostacyclin therapy at baseline. Refractory hypotension was noted in 7 patients of whom 5 patients required downtitration or discontinuation of baseline PAH therapies. Three patients had continuous inhaled epoprostenol added during their time on ECMO. In patients who were decannulated from ECMO, PAH therapies were typically resumed or titrated back to baseline dosages. One patient required no adjustment in PAH therapy while on ECMO. Two patients were not able to be decannulated from ECMO.

Conclusion:

The treatment of critically ill PAH patients is challenging given a variety of factors that could affect PAH drug concentrations. In particular, PAH patients on prostacyclin analogues placed on VA ECMO appear to have pronounced systemic vasodilation requiring vasopressors which is alleviated by temporarily reducing the intravenous prostacyclin dose. Patients should be closely monitored for potential need for rapid titrations in prostacyclin therapy to maintain hemodynamic stability.
Dynamic analysis of Sitar: A comparative study of operational and experimental modal analysis
Authors: Limkar Beena , Chandekar Gautam
Published: January 2022

Dynamic analysis of Sitar, an Indian string instrument, is important for better understanding of the instrument behavior during performance. Sitar has complex geometry, and most of its components have anisotropic material properties, which generate a lot of challenges in performing numerical modal analysis. Considering this, an experimental approach of operational modal analysis (OMA) is performed on Sitar to extract its natural frequencies using the Stochastic Subspace Identification method. Hammer or shaker excitation required for conventional experimental modal analysis (EMA) has huge limitations of using harder hammer tips and high magnitude force as the instrument is delicate. However, to validate OMA results, EMA is performed with extreme care using an instrumented hammer with soft tip and with a very low excitation force. PolyMAX algorithm is used in EMA. It is observed that most of the correlated OMA and EMA modes lie in the audible frequency range. The maximum absolute percent error observed for these frequencies is 2.14%. All the modes obtained in OMA are significant as the string excitation simulate close to the real-life performing situation. Most of these modes map to musical note frequencies. Considering the detrimental effect of excitation required for EMA, OMA is a recommended method for extracting modal characteristics of Sitar.
Functionally graded viscoelastic core characteristics on vibroacoustic behavior of double-walled cylindrical shells in a subsonic external flow
Authors: Reaei Shohreh , Talebitooti Roohollah
Published: January 2022

The present study is concerned with an analytical solution for calculating sound transmission loss through an infinite double-walled circular cylindrical shell with two isotropic skins and a polymeric foam core. Accordingly, the two-walled cylindrical shell is stimulated applying an acoustic oblique plane wave. The equations of motion are derived according to Hamilton’s principle using the first-order shear deformation theory for every three layers of the construction. Additionally, by the aid of employing the Zener mathematical model for the core of polymeric foam, mechanical properties are determined. To authenticate the results of this study, the damping of the core layer goes to zero. Therefore, the numerical results in this special case are compared with those of isotropic shells. The results prove that the presented model has high accuracy. It is also designated that decreasing the power-law exponent of the core leads to improving the sound transmission loss through the thickness of the construction. Besides, in addition to probe some configurations versus alterations of frequencies and dimensions, the convergence algorithm is provided. Consequently, it is realized that by increasing the excitation frequency, the minimum number of modes to find the convergence conditions is enhanced. The results also contain a comparison between the sound transmission loss coefficient for four different models of a core of a sandwiched cylindrical shell. It is comprehended that the presented model has a transmission loss coefficient more than the other types of the core at high frequencies.
Integrating Power and Gradual Institutional Change in Public Relations History: The Case of the People’s University in North Carolina After the Civil War
Authors: Lee Tae Ho
Published: January 2022

Drawing on the theory of gradual institutional change, this study analyzed the post-Civil War college reform efforts in North Carolina, integrating power with public relations history. Reformers worked under harsh institutional circumstances where resident elites held high veto power, while reformers had a low level of discretion for interpreting college education. Notwithstanding, reformers adopted layering tactics, introducing new rules of education for all alongside existing ones of education as legacy, for gradual institutional change. Specifically, reformers maintained a calm and objective tone, focusing on the universal value of education, both publicly and through anonymous publications in hostile press venues.
Waiting for Geotropic Forces: Bergsonian Duration and the Ecological Sympathies of Biodesign
Authors: Williams Nina
Published: January 2022

Biodesign disrupts the traditional temporalities of expectation and demand in wider design economies because designers are not selecting from a range of prefabricated samples from which they manufacture a product. Instead, they are plunged into the durations of other organisms for the simple reason that they must wait for something to grow. Situated in this context, this article considers how we might conceptualize these events of “waiting” such that we intensify their importance for ecological thought. In the philosophy of Henri Bergson, events of waiting are important as a mode of intuiting a register of movement beyond human habits of perception, what he refers to as duration. In this article, I suggest that thinking events of waiting in biodesign via Bergson intervenes in debates surrounding posthuman creativity, not because it multiplies creative agents but because it cultivates a sympathy for temporal ecologies from which human perception is alienated.
Nivolumab induced hypophysitis in an advanced RCC patient
Authors: Korkmaz Yilmaz Merve , Gulturk Ilkay , Tacar Seher Yildiz , Yilmaz Mesut
Published: January 2022

Introduction

Immune checkpoint inhibitors (ICIs) are being commonly used to treat solid tumours such as renal cell carcinoma. Hypophysitis is an acute or chronic inflammation of the pituitary gland and nivolumab or pembrolizumab induced hypophysitis is markedly lower compared to ipilimumab.

Case report

We present a novel case of a patient with mRCC who was diagnosed with nivolumab induced hypophysitis based on clinical suspicion due to his hormonal profile and a range of symptoms that he developed during nivolumab immunotherapy.

Management and outcome

He was treated with high dose of hydrocortisone administered intravenously, subsequently changed to the oral route and physiologic dose.

Discussion

Nivolumab induced hypophysitis is a rare condition that usually presents with fewer symptoms. High degree of clinical suspicion and a multidisciplinary team required to diagnose and treat such cases.
Early Development of ADHD and ODD Symptoms from the Toddler to Preschool Years
Authors: Brown Hallie R. , Laws Holly B. , Harvey Elizabeth A.
Published: January 2022

Objective:

ADHD and ODD are commonly co-occurring, but often studied individually. This study evaluated common trajectories of these disorders and explored how they co-develop in early childhood.

Method:

Community parents ( N = 273) completed online surveys about their 2-year-old. Children’s inattention, hyperactivity/impulsivity, and oppositional defiant disorder symptoms over 2 years were examined using latent class, dual trajectory, and cross-lagged analyses.

Results:

Most children followed low symptom trajectories. A small portion showed high, moderate, or increasing trajectories. The hyperactive/impulsive domain of ADHD showed a declining symptoms group. Children in high ODD groups were likely to be in high ADHD symptom groups; the converse was true but probabilities were lower. Hyperactive/impulsive symptoms predicted ODD symptoms across time, more than vice versa.

Conclusion:

The study extends the small body of literature assessing early development of ADHD and ODD. Findings suggest that earlier intervention for symptoms of ADHD may mitigate risk of developing ODD.
Rethinking Social Relationships in Adulthood: The Differential Investment of Resources Model
Authors: Huxhold Oliver , Fiori Katherine L. , Windsor Tim
Published: January 2022

Empirical evidence about the development of social relationships across adulthood into late life continues to accumulate, but theoretical development has lagged behind. The Differential Investment of Resources (DIRe) model integrates these empirical advances. The model defines the investment of time and energy into social ties varying in terms of emotional closeness and kinship as the core mechanism explaining the formation and maintenance of social networks. Individual characteristics, acting as capacities, motivations, and skills, determine the amount, direction, and efficacy of the investment. The context (e.g., the living situation) affects the social opportunity structure, the amount of time and energy available, and individual characteristics. Finally, the model describes two feedback loops: (a) social capital affecting the individual’s living situation and (b) different types of ties impacting individual characteristics via social exchanges, social influences, and social evaluations. The proposed model will provide a theoretical basis for future research and hypothesis testing.