bluuebunny/crossref_metadata_2025 huggingface dataset:
Urine-HILIC: Automated Sample Preparation for Bottom-Up Urinary Proteome Profiling in Clinical Proteomics
Authors: Govender Ireshyn Selvan , Mokoena Rethabile , Stoychev Stoyan , Naicker Previn
Published: September 2023

Urine provides a diverse source of information related to a patient’s health status and is ideal for clinical proteomics due to its ease of collection. To date, most methods for the preparation of urine samples lack the throughput required to analyze large clinical cohorts. To this end, we developed a novel workflow, urine-HILIC (uHLC), based on an on-bead protein capture, clean-up, and digestion without the need for bottleneck processing steps such as protein precipitation or centrifugation. The workflow was applied to an acute kidney injury (AKI) pilot study. Urine from clinical samples and a pooled sample was subjected to automated sample preparation in a KingFisher™ Flex magnetic handling station using the novel approach based on MagReSyn® HILIC microspheres. For benchmarking, the pooled sample was also prepared using a published protocol based on an on-membrane (OM) protein capture and digestion workflow. Peptides were analyzed by LCMS in data-independent acquisition (DIA) mode using a Dionex Ultimate 3000 UPLC coupled to a Sciex 5600 mass spectrometer. The data were searched in Spectronaut™ 17. Both workflows showed similar peptide and protein identifications in the pooled sample. The uHLC workflow was easier to set up and complete, having less hands-on time than the OM method, with fewer manual processing steps. Lower peptide and protein coefficient of variation was observed in the uHLC technical replicates. Following statistical analysis, candidate protein markers were filtered, at ≥8.35-fold change in abundance, ≥2 unique peptides and ≤1% false discovery rate, and revealed 121 significant, differentially abundant proteins, some of which have known associations with kidney injury. The pilot data derived using this novel workflow provide information on the urinary proteome of patients with AKI. Further exploration in a larger cohort using this novel high-throughput method is warranted.
Kaempferol Enhances Sperm Post-Thaw Survival by Its Cryoprotective and Antioxidant Behavior
Authors: Baňas Štefan , Benko Filip , Ďuračka Michal , Lukáč Norbert , Tvrdá Eva
Published: September 2023

This study examined the effects of three selected doses of kaempferol (KAE; 12.5, 25 or 50 μM) on bovine sperm motility and oxidative profile directly related to cold storage. We also elucidated the effect of KAE on the expression profiles of heat shock proteins (HSPs) 70 and 90 as well as the pro-apoptotic BCL2-associated X (BAX) protein and the anti-apoptotic B-cell lymphoma 2 (Bcl-2) protein. Frozen samples supplemented with KAE were compared with a native control (fresh spermatozoa) and a cryopreserved control, frozen in the absence of KAE. Our results demonstrate that the administration of all KAE doses led to a higher degree of sperm motility (p < 0.05) when compared with the cryopreserved control. The highest levels of protection of sperm DNA (p < 0.05), lipids (p < 0.05) and proteins (p < 0.05) were detected in samples exposed to 25 μM KAE when compared with samples frozen without KAE. Administration of 25 μM KAE led to a significant increase in HSP70 and HSP90 (p < 0.05) when compared with the unsupplemented frozen control. No significant differences were observed in the expression patterns of BAX; however, a significant up-regulation of Bcl-2 protein was observed in the frozen samples enriched with 25 μM KAE when compared with the cryopreserved control (p < 0.05). In summary, we may consider KAE as an effective agent in stabilizing the sperm membranes by preventing reactive oxygen species (ROS) overproduction in the mitochondria and subsequent oxidative damage to molecules critical for a proper sperm architecture and function. These protective properties of KAE may lead to higher post-thaw sperm activity and viability.
Evaluating Expressway Safety Based on Fuzzy Comprehensive Evaluation with AHP–Entropy Method: A Case Study of Jinliwen Expressway in Zhejiang Province, China
Authors: Zhang Shunfeng , Yu Xinlian , Mao Haijun , Yao Hua , Li Peiqing
Published: September 2023

To mitigate potential safety hazards during expressway operation, safety evaluation plays a crucial role. This study develops a fuzzy comprehensive evaluation model to assess the safety of expressway operations. First, an expressway operation safety risk assessment index system consisting of four criteria-layer indicators and 10 sub-criteria layer indicators is established. Then, the comprehensive weight of each evaluation index is calculated based on the combined AHP and entropy methods. Finally, the expressway safety level is obtained by converting qualitative indicators into fuzzy sets and defining corresponding membership functions to describe their degree of membership. The evaluation model is applied to the Jinliwen Expressway in a mountainous area in Zhejiang Province, China. The results show that the method could quantitatively and comprehensively evaluate the safety status of expressways and identify the weak links of operational safety management, which can effectively improve the safety level of expressway operations. The research findings will assist decision-makers in gaining a better understanding of the safety issues of expressways and, thus, using corresponding measures to enhance the safety level of the expressway.
Heat–Cool: A Simpler Differential Scanning Calorimetry Approach for Measuring the Specific Heat Capacity of Liquid Materials
Authors: Wada Brandon , Baldwin Oliver , Van Hecke Gerald
Published: September 2023

Specific heat capacity at constant pressure cp (J K−1 g−1) is an important thermodynamic property that helps material scientists better understand molecular structure and physical properties. Engineers control temperature (through heat transfer) in physical systems. Differential Scanning Calorimetry (DSC) is an analytical technique that has been used for over fifty years to measure heat capacities with milligram size samples. For existing procedures, such as ASTM E1269−11 (2018), the accuracy of molar heat capacity measurements is typically ±2–5% relative to the literature values, even after calibration for both heat flow and heat capacity. A comparison of different DSC technologies is beyond the scope of this paper, but the causes of these deviations are common to all DSC instruments, although the magnitude of the deviation (observed and accepted) varies with instrument design. This paper presents a new approach (Heat–Cool) for measuring more accurate and reproducible specific heat capacities of materials. In addition to better performance, the proposed method is faster and typically requires no additional calibration beyond the routine calibration of temperature and heat flow, with melting point standards common to all applications of DSC. Accuracy, as used throughout this paper, means deviation from the literature. The estimated standard deviation of repeated measurements of the cp values obtained with the Heat–Cool technique typically falls in the ±1–2% range.
Impact of Tracer Dose Reduction in [18 F]-Labelled Fluorodeoxyglucose-Positron Emission Tomography ([18 F]-FDG)-PET) on Texture Features and Histogram Indices: A Study in Homogeneous Tissues of Phantom and Patient
Authors: Vogel Jonas , Seith Ferdinand , Estler Arne , Nikolaou Konstantin , Schmidt Holger , la Fougère Christian , Küstner Thomas
Published: September 2023

Background: Histogram indices (HIs) and texture features (TFs) are considered to play an important role in future oncologic PET-imaging and it is unknown how these indices are affected by changes of tracer doses. A randomized undersampling of PET list mode data enables a simulation of tracer dose reduction. We performed a phantom study to compare HIs/TFs of simulated and measured tracer dose reductions and evaluated changes of HIs/TFs in the liver of patients with PETs from simulated reduced tracer doses. Overall, 42 HIs/TFs were evaluated in a NEMA phantom at measured and simulated doses (stepwise reduction of [18 F] from 100% to 25% of the measured dose). [18 F]-FDG-PET datasets of 15 patients were simulated from 3.0 down to 0.5 MBq/kgBW in intervals of 0.25 MBq/kgBW. HIs/TFs were calculated from two VOIs placed in physiological tissue of the right and left liver lobe and linear correlations and coefficients of variation analysis were performed. Results: All 42 TFs did not differ significantly in measured and simulated doses (p > 0.05). Also, 40 TFs showed the same behaviour over dose reduction regarding differences in the same group (measured or simulated), and for 26 TFs a linear behaviour over dose reduction for measured and simulated doses could be validated. Out of these, 13 TFs could be identified, which showed a linear change in TF value in both the NEMA phantom and patient data and therefore should maintain the same informative value when transferred in a dose reduction setting. Out of this Homogeneity 2, Entropy and Zone size non-uniformity are of special interest because they have been described as preferentially considerable for tumour heterogeneity characterization. Conclusions: We could show that there was no significant difference of measured and simulated HIs/TFs in the phantom study and most TFs reveal a linear behaviour over dose reduction, when tested in homogeneous tissue. This indicates that texture analysis in PET might be robust to dose modulations.
Long Term Follow-Up Study of a Randomized, Open-Label, Uncontrolled, Phase I/II Study to Assess the Safety and Immunogenicity of Intramuscular and Intradermal Doses of COVID-19 DNA Vaccine (AG0302-COVID19)
Authors: Nakagami Hironori , Matsumoto Tetsuya , Takazawa Kenji , Sekino Hisakuni , Matsuoka Osamu , Inoue Satoshi , Furuie Hidetoshi , Morishita Ryuichi
Published: September 2023

Pharmacological studies have demonstrated antibody production and infection prevention with an intradermal coronavirus disease 2019 (COVID-19) DNA vaccine (AG0302-COVID-19). This clinical trial aimed to investigate the safety and immunogenicity of high doses of AG0302-COVID19 when injected intramuscularly and intradermally. Healthy adults were randomly divided into three intramuscular vaccination groups (2 mg, three times at 2-week intervals; 4 mg, twice at 4-week intervals; and 8 mg, twice at 4-week intervals) and two intradermal groups (1 mg, three times at 2-week intervals or twice at 4-week intervals). After a one-year follow-up, no serious adverse events were related to AG0302-COVID-19. At Week 52, the changes in the geometric mean titer (GMT) ratios of the anti-S antibodies were 2.5, 2.4, and 3.2 in the 2, 4, and 8 mg intramuscular groups, respectively, and 3.2 and 5.1 in the three times and twice injected intradermal groups, respectively. The number of INF-γ-producing cells responsive to S protein increased after the first dose and was sustained for several months. AG0302-COVID-19 showed an acceptable safety profile, but the induction of a humoral immune response was insufficient to justify progressing to a Phase 3 program.
The Synergic Role of Emerging and Endemic Swine Virus in the Porcine Respiratory Disease Complex: Pathological and Biomolecular Analysis
Authors: Burrai Giovanni Pietro , Hawko Salwa , Dei Giudici Silvia , Polinas Marta , Angioi Pier Paolo , Mura Lorena , Alberti Alberto , Hosri Chadi , Hassoun Georges , Oggiano Annalisa , Antuofermo Elisabetta
Published: September 2023

Porcine respiratory disease complex (PRDC) represents a significant threat to the swine industry, causing economic losses in pigs worldwide. Recently, beyond the endemic viruses PRRSV and PCV2, emerging viruses such as TTSuV, PCV3, and PPV2, have been associated with PRDC, but their role remains unclear. This study investigates the presence of PCV2 and PRRSV and emerging viruses (PCV3, TTSuV, and PPV2) in the lungs of swine belonging to different age groups by histopathology and real-time PCR. The prevalent lung lesion was interstitial pneumonia with increased severity in post-weaning pigs. PRRSV was detected in 33% of piglets’ lungs and in 20% of adults and post-weaning pigs with high Ct, while PCV2 was found in 100% of adult pigs, 33% of post-weaning pigs, and 22% of piglets, with low Ct in post-weaning pigs. PCV3 was present in all categories and coexisted with other viruses. TTSuV was detected in all swine in combination with other viruses, possibly influencing the disease dynamics, while PPV2 was detected in 100% of adults’ and 90% of piglets’ lungs. The detection of TTSuV, PCV3, and PPV2 in affected pigs prioritizes the need for comprehensive approaches in implementing appropriate control measures and minimizing economic losses associated with PRDC.
Integrative Transcriptomics and Proteomics Analysis Reveals Immune Response Process in Bovine Viral Diarrhea Virus-1-Infected Peripheral Blood Mononuclear Cells
Authors: Zhang Kang , Zhang Jingyan , Wang Lei , Liang Qiang , Niu Yuhui , Gu Linlin , Wei Yanming , Li Jianxi
Published: September 2023

Bovine viral diarrhea virus (BVDV) causes bovine viral diarrhea-mucosal disease, inflicting substantial economic losses upon the global cattle industry. Peripheral blood mononuclear cells (PBMCs) are the central hub for immune responses during host-virus infection and have been recognized as crucial targets for BVDV infection. In order to elucidate the dynamics of host-BVDV-1 interaction, this study harnessed RNA-seq and iTRAQ methods to acquire an extensive dataset of transcriptomics and proteomics data from samples of BVDV-1-infected PBMCs at the 12-h post-infection mark. When compared to mock-infected PBMCs, we identified 344 differentially expressed genes (DEGs: a total of 234 genes with downregulated expression and 110 genes with upregulated expression) and 446 differentially expressed proteins (DEPs: a total of 224 proteins with downregulated expression and 222 proteins with upregulated expression). Selected DEGs and DEPs were validated through quantitative reverse transcriptase-polymerase chain reaction and parallel reaction monitoring. Gene ontology annotation and KEGG enrichment analysis underscored the significant enrichment of DEGs and DEPs in various immunity-related signaling pathways, including antigen processing and presentation, complement and coagulation cascades, cytokine-cytokine receptor interaction, and the NOD-like receptor signaling pathway, among others. Further analysis unveiled that those DEGs and DEPs with downregulated expression were predominantly associated with pathways such as complement and coagulation cascades, the interleukin-17 signaling pathway, cytokine-cytokine receptor interaction, the PI3K-Akt signaling pathway, the tumor necrosis factor signaling pathway, and the NOD-like receptor signaling pathway. Conversely, upregulated DEGs and DEPs were chiefly linked to metabolic pathways, oxidative phosphorylation, complement and coagulation cascades, and the RIG-I-like receptor signaling pathway. These altered genes and proteins shed light on the intense host-virus conflict within the immune realm. Our transcriptomics and proteomics data constitute a significant foundation for delving further into the interaction mechanism between BVDV and its host.
Vibration Minimisation of Moving Flexible Slender Structures Based on Time-Parameterised B-Spline
Authors: Riboli Marco , Manconi Elisabetta , Fusai Dario , Silvestri Marco , Aimi Alessandra
Published: September 2023

Vibration mitigation of moving flexible structures is a key issue in many applications. Examples include antennas, solar arrays, radar reflectors, and manipulator arms, especially in the aerospace sector. These structures typically consist of inter-connected slender and flexible elements moved by external actuators to reach specific configurations and positions. The movements excite vibrations, which lead to the risk of structural and fatigue failures; once in position, residual vibrations can be further amplified by structure lightness, causing bad performance and malfunctioning of onboard sensors. This paper proposes an effective technique to minimise the vibration of moving flexible structures by calculating the control points of a time-parametrised B-spline representing the shape of the motion law. A testing case of a rotating cantilever beam is considered. Validation using multi-flexible-body simulation software has shown the method’s effectiveness in minimising residual vibrations.
Manejo de residuos sólidos para el cuidado del medioambiente: una necesidad para la calidad de vida
Authors: Sumarriva-Bustinza Liliana Asunción , Zela-Payi Nelly Olga , Ticona-Arapa Haydee Clady , Chambi Condori Nancy , Chávez-Sumarriva Nadia Lys
Published: September 2023

Los residuos generados por el hombre siempre han existido, como problema ambiental es un fenómeno actual a nivel mundial, la actitud hacia el cuidado del medioambiente es un concepto global que se adapta a las necesidades de la sociedad la que es importante poner en práctica el manejo de los residuos sólidos. El objetivo de la investigación fue determinar la frecuencia de manejo de residuos sólidos para el cuidado del ambiente en docentes del Cono Sur de Lima. La investigación fue de tipo explicativo. La población estuvo conformada por 113 docentes. Llegando a los siguientes resultados sólo el 48.4% no conocen los tachos de reciclaje a nivel de colores y por tanto no hacen uso del manejo de residuos sólidos y sólo un 41.6% si conoce, por otro lado 62.9% sólo algunas veces cuidan el medio ambiente seguido por 30.9% casi nada y el 6.2% si lo hacen con frecuencia. Concluyendo que con los datos detallados aún queda por sensibilizar y poner en práctica el cuidado del medio ambiente y por ende el manejo de residuos sólidos a través de la responsabilidad, la honestidad, el compromiso en todos los agentes educativos las que recolectan y separan en diferentes depósitos aptos para este fin (orgánicos e inorgánicos)
Rule-based budgeting and the financial stability – the European solution
Authors: Kovács Árpád
Published: September 2023

From the perspective of his twelve years of service at the Fiscal Council of Hungary (Fiscal Council, FC, Council), the author reviews the so-called rule-based budgeting practices that have been in use in some sixty countries around the world for decades, and their role in creating and maintaining financial stability. The article refers to the possibilities of contribution of institutions overviewing the enforcement of fiscal rules while strengthening resilience to economic crises. It presents the links between EU and Hungarian legislation, and the main ideas that emerged in the preparation of the professional-political decisions for the further development of the system in order to better enforce fiscal responsibility. It proves that the framework and the body that enforces it have become a useful and indispensable part of the fiscal policy and, as its annual implementation, of the Hungarian budgetary practice.
Integration of financial institutions supported with data asset development – Magyar Bankholding case study
Authors: Vajda Gábor , Martzy Antal , Lovász Zoltán , Zéman Zoltán
Published: September 2023

Magyar Bankholding was created as a result of the integration of three large banks, where digitisation and data centricity, including also the creation of efficient data asset management, were emphasised from the very beginning. Our study investigates, as a case study, whether a survey and preparation work based on the maturity assessment method can shorten the implementation time of a data asset, estimated at 1 to 1.5 years, to 7 months in a complex bank integration process. The results were backtested one year after the work was completed, so all the effects could be evaluated. It can be concluded that the application of the methodology described in the study has had a positive impact not only on time requirements, but also on business, digitalisation and technological objectives.
Euro area economic growth between 2010 and 2019 in the light of secular stagnation theory
Authors: Tatay Tibor , Kazinczy Eszter
Published: September 2023

Achieving economic growth remains an important issue for economic policy today. Growth in developed economies has slowed considerably in recent decades. In our study, we examine economic growth in the euro area between 2010 and 2019 in the light of secular stagnation theory. The concept of secular stagnation was developed by Hansen after the Great Depression of 1929-33. According to this theory, the cauSes of secular stagnation are low population growth and weak technological development. The concept was brought back into the economic discourse after 2010 by Summers.
Heading Towards Third World Status? The Decline of the U.S. As A Global Economic Power
Authors: Petrikat Douglas , Tian Chan Claire Yi
Published: September 2023

There is an expectation that China will surpass the U.S. economy, around the year 2035. However, this development will involve more than Americans just moving to the number two spot in the world pecking order. The U.S. is undergoing a political and cultural transformation in which it is taking on characteristics and practices associated with developing nations of the third world. If this trend continues Americans could experience a lower standard of living, a shrinking military, and a loss of political and cultural influence. We could witness the decline of the U.S, as a major power, losing its competitive edge, to the extent that its role in international affairs will significantly diminish. Political and social conflict within the U.S., along with increasing instability, could lead to the breakup of the nation into several North American states. This paper will discuss and analyze developments in the U.S. which could lead to the end of its status as a first world global power.

Keywords: Third World Status, Global Economic Power, Economy.
Do the Characteristics of Family or Non-family Businesses Matter in Explaining Earnings Quality?
Authors: Karyawati Purba Golrida , Natasha Surya Audrey , Lal Joshi Prem , Tyagi Anshu
Published: September 2023

This study examines whether the characteristic of family or non-family businesses matters in explaining earnings quality. This study analyzed 312 firms listed on the Indonesia Stock Exchange (IDX) for the period 2016–2020. To obtain robust results on the relationship between FB/NFB characteristics and earnings quality, this study measures earnings quality comprehensively, including measurements of available opportunities for earnings management, earnings management practices, earnings persistence, earnings restatement, and investor responsiveness to earnings quality. The regression analysis panel is employed to examine the effect of FB and NFB characteristics on earnings quality. Overall, the results prove that FB earnings quality is better than NFB earnings quality. The results of this study extend the implementation of socioemotional wealth theory in explaining the characteristics of FB, in which the characteristics of FB and non-FB have an impact on earnings quality. The results of this study are useful for financial statement analysts in interpreting earnings quality based on the characteristics of FB and NFB. The results of this study are also useful for investors in understanding financial statements as part of the fundamental analysis of investment decisions.

Keywords: Earnings Quality, Family Business (FB), Non-family Business (NFB), Socioemotional Wealth Theory
The Effect of Overall E-Service Quality to Online Customer Satisfaction After Covid-19
Authors: Suthia Hayu Rina , Sutanpri  , Sahputra Heldi , Hermice Nopi
Published: September 2023

E-commerce companies such as Tokopedia during the Covid-19 outbreak are vying to provide the best service for consumers. For example, they try to provide free shipping promos,discount, give away, quizzes with prizes and so on, they even still use this strategy until now entering the Post-Covid-19 Pandemic period.However, in providing promotional offers to attract consumers to visit e-commerce This is not a major factor in determining whether consumers will buy the products or service offered, because many other similar platforms also do the same thing and maybe it will be even more tempting for consumer. Therefore, it will be better for e-commerce to focus more on providing satisfaction that can lead to purchasing decisions and make them loyal (Tobagus, 2018). Providing quality service to satisfy consumers is what all e-commerce aims for, because if the consumer is satisfied with the product purchased and the service obtained it will bring profit to the e-commerce and can survive in today's increasingly fierce competition. So, it is hoped that in the future it will provide profound contributions and benefits related to influence Overall E-service Quality to Online Customer Satisfaction on the Tokopedia marketplace which was researched and reviewed after the Covid-19 Pandemic. From the results of this research later, it is expected to emerge new indicators which will open the researcher's discourse regarding variables of E-service quality and Online Customer Satisfaction on online shopping platforms. Researchers estimate that there will be demands for different service standards when shopping using Tokopedia E-commerce before the Pandemic and after the Covid-19 Pandemic.

Keywords: Covid-19, E-Commerce, Overall E-Service Quality, Customer Satisfaction
The Impact of Technologies on Value Co-Creation in the Music Industry: Blockchain, Augmented Reality and ChatGPT - OpenAI
Authors: Irina Lazăr (Negrea) , Gheorghe Epuran , Bianca Tescașiu
Published: September 2023

The new information technologies changed the communication paradigm and brought new elements in the way the newly created value is perceived. The possibilities of co-creating value in the music field are growing strongly in the context of the development of technological applications such as Blockchain, Augmented Reality and, more recently, ChatGPT. They open new horizons in the creation, distribution and promotion of musical works by artists and producers (Centorrino at al., 2023), with the benefits for end users being ever greater. Through new technologies and applications, businesses in the music industry acquire new facets and dimensions, where passionate users, (music lovers, artists and other interested parties interact), thus contributing to the co-creation of value. The purpose of this research is to establish how and to what extent Blockchain, Augmented Reality and Chat GPT technologies contribute to added value through co-creation in the music industry.

Keywords: value co-creation, music, Blockchain, Augmented Reality, ChatGPT.
Corporate Political Activism as a Potential Role of Corporations
Authors: Katona Klára
Published: September 2023

Traditionally economic theory, or political economy, distinguished between the private, the economic, and the political spheres of society. Charity and other kind of benevolent actions were relegated to the private sphere as moral duties, or to government policies as political duties. But if we consider the activity, donations of time and money by natural persons as an evident manifestation of the civil sector, as an accepted form of socio-economic division of labor, why do we consider similar activities by legal persons as illegitimate? The answer to this question is usually that corporations are neither voters nor democratically empowered to carry out such activities.

Keywords: CEOs capitalism, corporate capitalism, corporate citizenship, corporate political activism, CSR
The mediating effect of knowledge sharing and usage on Human Resource Practices and Innovative Behavior: Developing vs. countries of crisis
Authors: Sayegh Niveen
Published: September 2023

Purpose: As the work context and the national setting of countries are dynamically evolving, enhancing managerial human resource practices (HRP) is critical, to augment and enrich employee innovative behavior (IB) while promoting positive knowledge usage (KU) and sharing (KS). Henceforth, this paper examines their latent ambidexterity as a consequence of HRP and strategies. Design/methodology/approach: After a thorough literature review revealing evidence of relationship that adjoins HRP and IB as a result of the mediations between KS and KU. A quantitative questionnaire is designed and the data are analyzed via the SPSS software, taking into account that the data focused on respondents from Lebanon and GCC region. Correlations between the variables and the mediators is thoroughly examined and investigated. Findings: There is a direct relationship between HRP and IB through a partial sequential mediation of KS and KU in GCC region. On the other hand, it is identified that the effects of HRP and IB are significant solely upon the verdict of a sequential mediations between the mediators. Originality/value: This study yields a profound apprehension of the correlation between HRP and IB in the workplace along with the mediating roles of KS and KU on the relationship. Contributing in highlighting the role of effective HRP in organizations, while inculcating managers to the proper way of utilizing KS and KU according to the macroenvironment of the organization. Which in this study focused on Lebanon a country facing a revolutionary crisis and the GCC region that are witnessing unprecedently prosperity and wealth. This relationship is uniquely designed to study the relationship between the variables at hand, examining the outcome of the study prototypically in Lebanon and the GCC region.

Keywords: HRM practices, Innovation, Knowledge usage, Knowledge sharing, Crisis
Kentsel Dönüşümde Toplumsal Mekânsal Adaletin Boyutlarının Değerlendirilmesi: Ankara İmrahor Vadisi, Güneypark Kentsel Dönüşüm Projesi Örneği
Authors: TIĞLI Emine , TUNCER Mehmet
Published: September 2023

Kentsel dönüşüm kentin eskiyen kısımlarının yenilenmesi, yeniden geliştirilmesidir. Genellikle kentin merkezinde yer alan, mülk sahipleri ve farklı kullanıcıları bulunan kentsel dönüşüm alanlarında mülkiyet hakkı, barınma hakkı gibi temel haklara müdahaleler gerçekleştirilmektedir. Bu sebeple kentsel dönüşüm alanlarında sosyal ve mekânsal adaletin sağlanması tüm dünyada büyük önem arz etmektedir. Bu çalışmada, Ankara İli, İmrahor Vadisi, Güneypark Kentsel Dönüşüm Projesi incelenmiştir. Araştırmanın amacı kentsel dönüşüm alanlarında mekânsal toplumsal adaletin boyutlarının sürdürülebilir kalkınma anlayışı çatısı altında seçilen proje üzerinden tartışılmasıdır. Araştırmayı özgün kılan yaklaşımdan ilki, toplumsal mekânsal adaletin boyutlarının Gündem 2030 çerçevesindeki sürdürülebilir kalkınma amaçlarına dayandırılarak belirlenmesidir. İkincisi ise şemqlaştırılan sürdürülebilir kentsel dönüşümün süreç adımları sistematiği içerisinde araştırma sahasındaki verilerin tartışılmasıdır. Böylece toplumsal mekânsal adalet gibi soyut bir kavram, kentsel dönüşüm gibi kapsamlı bir uygulama içerisinde analiz edilerek, çalışmanın bulgularıyla ve yöntem yaklaşımıyla literatüre katkı sağlanmıştır.
Assessment of personal, interpersonal and social factors related to resocialisation of convicted individuals
Authors: Zlokazov Kirill
Published: September 2023

Abstract: Introduction. The research is aimed at studying the difficulties of convicts’ resocialisation as well as individuals subjected to administrative supervision. The relevance of the study is based on the social significance of countering recidivism, reducing the level of offences, as well as the necessity to gain new scientific knowledge concerning the resocialisation factors. The problem of the study is in the lack of a comprehensive understanding of resocialisation factors, diverse ideas about personal and interpersonal characteristics, and social factors disrupting resocialisation process. Research methods include theoretical methods of cognition: generalisation, categorisation and systematisation of information regarding the factors contributing to the resocialisation of convicted individuals; empirical methods of cognition: questionnaire, mathematical and statistical analysis - descriptive statistics, exploratory factor analysis, comparative analysis – Mann–Whitney U-criterion. Results of the study. The diverse socio-psychological causes of resocialisation disorders were generalised in the form of a three-component model describing personal characteristics, interpersonal relations and social conditions. The empirical study of perceptions of the causes of resocialisation was carried out. The sample included individuals serving sentences in correctional institutions of the Federal Penitentiary Service of Russia, individuals under administrative supervision (n = 252) and law enforcement officers (n = 232). Conclusions. The theoretical model of resocialisation difficulties has been verified. Differences in the perception of the reasons causing resocialisation failures in the group of convicted individuals and law enforcement officers have been established. Recidivists are characterised by the desire to blame the social environment, underestimation of their own negative personal characteristics and social conditions. These include alcohol and other addictions, their manipulation of others, retention of a criminal lifestyle, idleness and hedonism. Law enforcement officers are characterised by increased attention to the conditions of social functioning and negative personal characteristics of ex-convicts. The results broaden and clarify scientific ideas about the factors that impede resocialisation, and the tools developed in the course of the study have been tested and are applicable for the practical study of a set of socio-psychological problems of integration of convicted individuals into the community.
Prevention activities by transport police agencies toward administrative offences in the sphere of illegal exploitation of aquatic biological resources
Authors: Panfilova Ol'ga , Demchenko Nikolay
Published: September 2023

Abstract: Introduction. The fundamental goal of our state in the sphere of the use and protection of aquatic biological resources is the comprehensive enforcement of thelegislation not only by economic entities, but also by all parties concerned, aimed at conservation of biological natural resources. Fishingfor some small northern peoples of Russia is their means of existence, and for example, in the coastal regions of Kamchatka, Primorsky and Sakhalin Territory and some others, fishing is the main type of employment for the population living there. Despite this, it should not be forgotten that biological resources as alimentary raw materials are restored under conditions of their rational use and control by the state. Ill-considered and irrational use of biological resources will ultimately lead to the complete disappearance of aquatic biological resources. In recent years, a significant increase in offenses related to the use of aquatic biological resources has been recorded in the Russian Federation. In this regard, law enforcement agencies, state control and supervision bodies in the sphere of protection of aquatic biological resources jointly carry out many preventive measures to counter such offenses and to identify the causes and conditions of their commission. Methods. Working on the paper, we used the research method, methods of analysis of the current legislation, as well as available statistical indicators of the activities of territorial bodies of the Ministry of Internal Affairs of Russia on transport and othergovernment institutions exercising supervision, control and protection of aquatic biological resources. Results.This article discusses administrative offenses inthe sphere of illegal harvesting of aquatic bioresources and preventive measures taken bytransport police agencies to hinder the violations in question. The statistics of preventive measures carried outbyterritorial law enforcement bodies on transport and other government institutions exercising supervision, control and protection of aquatic biological resourcesare analyzed. The main areas of activity and measures taken by the relevant authorities to prevent offenses in the sphere of illegal harvesting of aquatic biological resources are also highlighted.
PARAPHARYNGEAL SPACE PLEOMORPHIC ADENOMA PRESENTING AS PERITONSILLAR ABSCESS.
Authors: Dogra Priya , Singh Yogendra
Published: September 2023

The parapharyngeal space tumors are one of the most challenging head and neck tumors for diagnosis and treatment. The most common tumor
arising from PPS is pleomorphic adenoma. The tumor mostly has female predilection. The usual presentation is slowly progressive asymptomatic
swelling in this region. In this case report, patient presented with oropharyngeal mass. Aim of this case report is the atypical presentation of the
tumor as peritonsillar abscess and its line of diagnosis and treatment. Surgical excision of tumor forms main stay of treatment.
MRI EVALUATION OF ABNORMAL FEMALE PELVIS: A CASE SERIES OF TWELVE PATIENTS IN A TERTIARY INSTITUTE IN CHEVELLA (RANGAREDDY)
Authors: Pallavi N , D Sravya , Aironi Vyankatesh , Kotha Reddy Preethi , Venkateshwar Reddy D , Teja Reddy Timira
Published: September 2023

Background MRI evaluation of female pelvis is well established imaging modality of choice because of its excellent soft tissue contrast resolution,
providing high contrast images of abnormality in pelvis along with excellent visualization of soft tissue planes in and around abnormal tissue 1, 4 &
5. Especially in the pelvic female masses, the multiplanar imaging capability of MRI and high inherent soft tissue contrast details help in
establishing correct tissue-specic diagnosis, differentiation between malignant and benign lesions, thereby directing clinician to decision making
as to operate or give conservative treatment 1, 4, 5 & 6. It helps also in pre-surgical road-mapping in case surgery is necessary & contemplated for 1,
4, 5 & 6. This case series highlights excellent diagnostic imaging capability of MRI diagnostic tool in such diverse variety of pelvic abnormalities in
female patients. In our present retrospective case series of twelve abnormal female pelvis Methods , which we evaluated on state-of-the-art 1.5
Tesla MRI scanner, we came across a different & diverse case spectrum of abnormal female pelvis involving uterus, ovaries & lower abdominal
wall. The study was done in the Department of Radio-diagnosis, Dr. Patnam Mahender Reddy Institute of Medical Sciences and Hospital, Chevella
(Rangareddy, Telangana state, India) in the month of June, July & August 2023. The age group of patients included in this series range from 16 years
to 70 years, including patients of reproductive age group and also post-menopausal age group. W Results e found ve uterine conditions including
multiple broids, adenomyomatosis of uterus & Caesarean scar abnormalities. Other 6 cases were of ovarian pathology like simple follicular
ovarian cysts, serous cystadenomas and ovarian endometriosis. One case of right para-uterine pelvic collection secondary to infected hernial mesh
along the lower abdominal incisional scar was seen with Caesarean scar adhesions of uterus with both urinary bladder and abdominal incisional
scar site. One other case revealed adenomyotic bulky uterus adherent to the LSCS abdominal wall scar along with scar endometriotic cystic lesions
in the lower anterior abdominal wall for which surgical excision were done later. No malignant lesion was found in our case series. Conclusions
The specic diagnosis provided just on plain MR studies, lead to decision to go ahead with surgical management in few of rare situations such as
Caesarean scar endometriosis adherent to adenomyotic bulky uterus and another case of infected hernial mesh along Caesarean surgical scar with
pelvic collection. Ovarian endometriosis was treated conservatively. Surgery is being planned for cases of large ovarian cystadenomas, uterine
broids & Adenomyomatosis of uterus.
BLOOD DONOR DEFERRALS DURING COVID PANDEMIC- A RETROSPECTIVE OBSERVATIONAL STUDY.
Authors: Sharma Ankit , Singh Meena Bheem , Chaudhary Muskan
Published: September 2023

Background and Objectives Blood donor deferral has been an essential tool for blood safety. The COVID-19 pandemic has affected blood
transfusion services mainly its impact on donor deferral rate,donations considerably compromised due to the non availability of blood donors.
Materials and Methods The retrospective observational study was done based on our annual collection of 2021- 2022 .All the deferred donors
were divided into different categories: (1) medical causes, (2) surgical causes, (3) drugs and vaccination, (4) risk of transfusion-transmitted
diseases, (5) miscellaneous causes and (6) u-like symptoms covering COVID-related deferrals, donor demography were analysed by SPSS
software version 25. The donor deferral rate was 12.84% during COVID periods. During the pre-COVID Results period, Category 1 and 3
deferrals and during COVID period, Category 6 deferrals were signicantly higher. Category 1 deferral was more in middle-aged adults as
compared to young and old adults (p < 0.05). COVID-19 signicantly affected the donor pool changing Conclusion the pattern of donor deferral.
The study helped in identifying targeted donor populations and planning donor recruitment strategies in future pandemic crises.
ASSOCIATION OF BENIGN BREAST DISEASES WITH HYPOTHYROIDISM AND ESTIMATION OF TSH LEVELS
Authors: Saran Paras , Srivastava Vaibhav , Chaurasiya Vinay , Varma Kachnar
Published: September 2023

Aims And Objectives : Estimation of TSH levels in patients of Benign Breast Diseases and to nd out the association of Benign Breast Diseases
with Hypothyroidism. Materials And Methods The present study was carried out in P.G. Department of surgery, S.R.N. Hospital associated with
M.L.N Medical college, Prayagraj from October 2021 to September 2022 after approval from the ethical committee and after obtaining written and
informed consent from the patient. Study Design: Case - Control Study. Sampling method was time bounded Universal sampling. Sample size of
112 cases and 112 controls were selected for the study. Among the participants, Cases were patients with Benign BBDs & Controls were patients
without BBDs. Result In our study it was found that Hypothyroidism was more common in cases (25/112 cases i.e., 22.3%) than in controls (13/112
controls i.e., 11.6%). Hypothyroidism was found more in the cases group, and statistically signicant relationship was found in between
Hypothyroidism and BBDs when compared to the controls group. Conclusion The study demonstrated an increased prevalence of hypothyroidism
in cases of BBDs that presented at our centre when compared to the selected controls. The nding being statistically signicant, it can be concluded
that there is an association between BBDs and Hypothyroidism. Hence screening of Hypothyroidism should be advocated in all the patients of
BBDs to screen for undiagnosed/subclinical hypothyroidism.
HISTOMORPHOLOGICAL SPECTRUM OF CUTANEOUS TUBERCULOSIS IN TERTIARY CARE HOSPITAL- A CASE SERIES
Authors: Vinayak Agale Shubhangi , Shripad Dhawle Manjusha , Ali Pirosha Arva , Vinodkumar Rathi Vanita
Published: September 2023

Introduction- Cutaneous tuberculosis constitutes 1-1.5% of all extra-pulmonary tuberculosis. Cutaneous tuberculosis reveals diverse clinical
presentation ranging from papules, pustules, papulonecrotic, painful nodules, verrucous lesions, panniculits, plaques, ulcers, sinuses, scars and
may mimic other inammatory skin diseases hence clinicopathological correlation is necessary for early diagnosis of cutaneous tuberculosis.
Histopathology is gold standard for diagnosis of cutaneous tuberculosis; however ancillary tests such as Mantoux test, mycobacterial culture, gene
expert studies and amplication of mycobacterial DNA by PCR (Polymerase Chain Reaction) are necessary for conrmation of diagnosis. 1. AimsTo study clinico-pathological correlation and histological features of various morphological subtypes of cutaneous tuberculosis 2. To record
incidence, age-gender distribution and common histological subtype of cutaneous tuberculosis. We studied various Material And Methods -
morphological subtypes in 12 patients with strong clinical suspicion of cutaneous tuberculosis, out of 602 total skin biopsies received in
histopathology department from January 2022 to December 2022. On histopathology, 3 cases of Lupus V Results- ulgaris (25%) followed by 2
cases of Lichen Scrofulosorum (16.16%), Erythema Induratum of Bazin (16.16%), Papulonecrotic Tuberculid (16.16%), Erythema Nodosum
(16.16%) each and 1 case of Scrofuloderma (8.33%) were diagnosed. Incidence of cutaneous tuberculosis was found to be 1.99%. Age group of the
present study ranged from 15-52 years. Most cases occurred in the age group of 20-30 years with female predominance. Most commonly involved
site was the lower extremities. Cutaneous tuberculosis is an uncommon condition which is ass Conclusions- ociated with signicant morbidity.
Diagnosis of cutaneous tuberculosis can be challenging due to varied clinical presentation and wide range of differential diagnoses. Early and
expeditious diagnosis is important for effective management of patient.
ANGIOGRAPHIC PREVALENCE AND PATTERN OF MYOCARDIAL BRIDGE IN PATIENTS UNDERGOING CORONARY ANGIOGRAPHY AT TERTIARY CARE CENTRE IN RAJASTHAN
Authors: Prasad Sinha Ramanand , Thakur Manas , Wardhan Harsh
Published: September 2023

Myocardial bridge (MB) is a congenital coronary anomaly, diagnosed in many patients on routine coronary angiography. We evaluated the
prevalence, pattern and incidence of associated coronary artery disease (CAD) and mode of revascularisation among them. Material And
Methods: This was retrospective, open labelled, single centre, observational based study. Systolic compression and diastolic normalisation of
coronary arteries are diagnosed as myocardial bridge. MB associated with signicant CAD is diagnosed when coronary artery diameter ,
narrowing (>70 %) is seen in diastole. Over the period of 5 years (2018 -2022), 6428 patients we Result: re enrolled out of which MB was
diagnosed in 51 patients. It was present only in Left anterior descending artery (LAD).The prevalence varies from 0.5-1.2 %. 8 patients were
associated with signicant CAD and in all of them, CAD was present from proximal to bridge segment. All of them were advised for coronary
revascularisation and 3 patients underwent coronary angioplasty with stent. MB are Conclusion: not uncommon, and patients who were taken for
coronary angiography, must be carefully analysed for MB. Almost all were present in LAD.Signicant CAD was present from proximal to bridge
segment. We need further large,multi-centre database for its treatment as per the guidelines.
LOW GRADE APPENDICEAL MUCINOUS NEOPLASM – A RARE CASE REPORT
Authors: K Kavithamani , K Bhavani , J Prabhavathy
Published: September 2023

Low-grade appendiceal mucinous neoplasm (LAMN) is a rare mucinous tumour of appendix with low grade cytologic atypia. Patients presents
with variable symptoms depending on the clinical manifestations. They can be often misdiagnosed as acute appendicitis or as retroperitoneal
tumour. The most frequent complication of LAMN is Pseudomyxoma peritonei (PMP) which leads to mucin implants in the adjacent peritoneum.
They are treated surgically with complete resection of the appendix, when it is non – metastatic. We report an unusual case of a 60-year-old male
found to have LAMN status post elective appendectomy, six months after being treated for an appendiceal abscess.