bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy and feasibility of Intradialytic Plantar Electrical Stimulation in patients with diabetes: A Randomized Double-Blind Controlled Trial
Authors: Lee Myeounggon , Hamad Abdullah , Azarian Mehrnaz , Beom Jaewon , Ouattas Abderrahman , Dehghan Rouzi Mohammad , Rodriguez Naima , Quach Nhi , Ibrahim Rania , Mathew Mincy , Talal Talal , Al‑Ali Fadwa , Najafi Bijan
Published: September 2024

OBJECTIVE

This study investigates the efficacy and feasibility of electrical stimulation (E-Stim) on sensory fibers of the plantar region during hemodialysis (HD) sessions, aiming to improve mobility in diabetes patients by providing a connection between electrical stimulation and enhanced mobility with minimal patient effort required.

RESEARCH DESIGN AND METHODS

Participants 18 and above, undergoing HD in the diabetes patients, and able to walk at least 10 meters with or without aid, were recruited and divided into an intervention group (IG) receiving 1-hour intradialytic E-Stim 3 times/week, and a control group (CG) using an identical non-functional device, for 12-week. Gait, physical activity, patient-reported outcomes, and the technology acceptance model were assessed to evaluate the intervention's effectiveness and acceptance.

RESULTS

Out of 117 initial participants, 97 completed the study. Significant improvements were observed in the IG compared to the CG in gait performance (stride time at dual-task and fast walking), physical activity (stand-to-walk and sit-to-stand), quality of life, plantar numbness, and cognitive function after 12-week. The IG showed magnitude of improvements on gait performance and physical activity metrics are associated with enhancements on quality of life and cognitive function, respectively. The IG also reported higher 'usefulness' and 'usage satisfaction', with a greater willingness to continue using E-Stim at home.

CONCLUSIONS

The 12-week intradialytic E-Stim intervention is a feasible and effective method to enhance gait performance, physical activity level, cognitive function and other patient-reported outcomes in HD patients, representing a practical, low-risk therapy option for those unable to engage in traditional exercise programs.
Exploring Patients’ Perceptions of One-step Surgery for Primary Cutaneous Melanoma: A Qualitative Study
Authors: Lim Margueritte , Kervarrec Thibault , Mourtada Youssef , Chaput Laura , Lebeau Jean-Pierre , Machet Laurent
Published: September 2024

High-frequency ultrasonography (> 20 MHz) has allowed for preoperative measurement of melanoma thickness and thus a one-step surgery strategy. The potential benefits of one-step surgery to patients remain unexplored. From June 2022 to August 2023, 2 dermatologists conducted semi-structured individual interviews with patients who had undergone HFUS examination allowing the choice for one-step surgery (group A) and with patients who had had standard two-step surgery (group B). Analysis of interviews with 21 patients (age range 31–81 years) revealed 5 main themes: (a) understanding the diagnosis, highlighting the significance of clear and comprehensive medical explanations; (b) personal factors considered in treatment decisions, including preferences for minimizing surgical procedures; (c) making choices, bearing responsibility, thus showcasing different levels of patient involvement in decision-making; (d) high- frequency ultrasonography reassurance emphasizing the role of medical reassurance, and (e) patient satisfaction, discussing surgical outcomes and the decision-making process. The majority of participants expressed a clear preference for one-step surgery, perceived as a pragmatic and fast surgical strategy while minimizing interventions. In conclusion, the results emphasize the importance of patient-centred care. These insights can guide improved preoperative consultations and enhance shared decision-making between healthcare professionals and patients regarding melanoma treatment strategies.
Non-protuberant Lesions and Diagnostic Delays in Dermatofibrosarcoma Protuberans: A Single Institutional Retrospective Analysis
Authors: Akome Jun , Ishitsuka Yosuke , Tanemura Atsushi , Kubo Tateki , Fujimoto Manabu
Published: September 2024

Abstract is missing (Short communication)
Enhancing upper extremity muscle strength in individuals with spinal cord injury using low-intensity blood flow restriction exercise
Authors: Shadgan Babak , Nourizadeh Mehdi , Saremi Yekta , Baktash Leila , Lazarevic Stefan
Published: September 2024

Objectives: This study explores the feasibility and effects of low-intensity blood flow restriction exercise on forearm muscle strength and function in individuals with spinal cord injury.
Study design: Pilot randomized clinical trial.
Patients and methods: Ten male and female adult participants with chronic cervical and thoracic spinal cord injury underwent an 8-week low-intensity blood flow restriction exercise programme that targeted forearm muscles. Each participant’s contralateral forearm served as the control. Grip strength was the primary outcome measure, and participants also provided qualitative feedback on their experiences.
Results: The study revealed a significant increase in participants’ forearm muscle strength on the experimental side engaged in low-intensity blood flow restriction training, with an average strength gain of 7.5 ± 0.36 kg after 16 exercise sessions (Cohen’s d = –6.32, 95% CI –8.34, –6.68). In comparison, the control side, following a conventional high- intensity exercise regimen without BFR, showed a more modest strength increase of 4.4 ± 0.67 kg. A mean Patient’s Global Impression of Change score of 2.2 reflected overall improvements in participants’ daily activities and health status.
Conclusion: This study highlights the feasibility and effectiveness of low-intensity blood flow restriction exercise as a safe and promising approach to enhancing forearm muscle strength in individuals with spinal cord injury. The observed positive outcomes, coupled with a high level of participant satisfaction, underscore the potential of this innovative method to significantly improve limb muscle strength, thereby contributing to greater functional independence in this population.
In vitro assessment of antifungal activity of cinnamon leaves extract against the Colletotrichum sp. causes of anthracnose on tomato
Authors: Sudirga Sang Ketut , Darmadi Anak Agung Ketut , Saka Wijaya I Made , Yulihastuti Dwi Ariani
Published: September 2024

Tomato is a horticultural plant widely cultivated in Bali. Over the three years, the productivity and quality of this plant have tended to decrease due to pathogen-derived diseases, such as anthracnose caused by Colletotrichum sp. Until recently, control of this pathogenic fungus has relied on chemical-based fungicides, which lead to many long-term complications, including pathogen resistance, environmental pollution, the extinction of non-target microorganisms, and negative impacts on human health. Therefore, alternative methods for plant disease control are urgently needed to combat these pathogen attacks. The use of plant-derived active compounds has been intensively researched worldwide as a more environmentally friendly alternative. The main objective of this research was to investigate the effectiveness of Cinnamomum burmanii acetone extract in inhibiting the growth of Colletotrichum sp., the causative agent of anthracnose in tomatoes, through an in vitro approach. A non-factorial randomized complete design was applied in the experiment. The results showed that the crude extract of cinnamon leaves inhibited the growth of the Colletotrichum sp. with an MIC value of 0.9%, an inhibition zone of 2.55 mm, and an optimal inhibitory concentration of 2%, producing an inhibition zone of 11.10 mm. A GC-MS analysis was conducted to identify the active compounds in the cinnamon leaf extract. Sixteen active compounds were identified, nine of which are known to have antimicrobial activity.
Assessment of Risk Factors for Women with Iron Deficiency Anemia During Pregnancy
Authors: Muhsen Maha Abdulredha , Hamad Dheya Shinyar
Published: September 2024

Background: Globally, iron insufficiency is the most common nutrient deficiency and the primary cause of anemia. Iron deficiency can result in maternal anemia and decreased infant iron reserves due to increased iron demand during pregnancy.
Objective: The study was designed to assess the risk factors encountered during pregnancy among pregnant women with iron deficiency anemia.
Materials and Methods: The study was conducted on one hundred pregnant women enrolled on the health care centers who were diagnosed as anemic. The data were obtained from all through direct interviews using a special questionnaire covering the sociodemographic characteristics, diet habits, and supplements taken during pregnancy. The one-way ANOVA test analysis was done to see the association of each variable with the anemia severity. The probability value <0.05 was considered statistically significant.
Results: The results indicated that there was no statistically significant relation between iron deficiency anemia and all the socio-demographic characteristics which included; age, parity, educational level, occupation, family size, and gestational age. While there is a highly statistically significant relation between iron deficiency anemia and diet habit of pregnant women regarding the frequency of intake of meats, fishes, vegetables, and fruits at p-value = 0.001, intake pulse at p-value = 0.012, intake of nuts at p-value = 0.021, and drinking tea at p-value = 0.001.
Conclusion: Educating pregnant women to eat iron-rich foods may be useful as a strategy for reducing iron deficiency anemia during pregnancy, also using of iron supplements, folic acid and vitamin B12 is regarded as a successful way to treat anemia.
Assessing the Impact of Hyperthermic Intraperitoneal Chemotherapy on Anastomotic Integrity after Cytoreductive Surgery in Gastrointestinal Malignancies
Authors: Meneses do Rêgo Amália Cinthia , Araújo-Filho Irami
Published: September 2024

Peritoneal carcinomatosis (PC) from gastrointestinal malignancies, particularly colorectal and gastric cancers, represents a significant therapeutic challenge due to the diffuse nature of tumor spread. The combination of cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has emerged as a promising treatment modality, offering potential survival benefits by targeting residual microscopic disease. However, this aggressive approach is associated with a heightened risk of gastrointestinal anastomotic leaks, one of the most severe complications of gastrointestinal surgery. These leaks result from a complex interplay of factors, including hyperthermia-induced ischemia, chemotherapy-induced cytotoxicity, and a pro-inflammatory cytokine cascade involving IL-6, TNF-α, and IL-1β, which impair tissue healing. Furthermore, dysbiosis of the intestinal microbiota induced by HIPEC contributes to local inflammation and an increased risk of infection, exacerbating the likelihood of anastomotic failure. The duration and temperature of the HIPEC procedure, the extent of surgery, and the patient’s performance status and tumor burden further influence the risk of leaks. Preventive strategies such as preoperative nutritional optimization, meticulous surgical technique, intraoperative reinforcement of anastomoses, and selective use of protective ileostomies are critical for minimizing these risks. Early detection and prompt management of leaks are essential for reducing morbidity and mortality, improving both short-term and long-term outcomes. This review comprehensively examines the multifactorial causes of anastomotic leaks in the setting of CRS and HIPEC and highlights potential strategies for prevention and improved management.
Improving the Accuracy of Manual Control of an Automatic Guided Vehicle (AGV) Robot by Applying the Proportional Integral Derivative (PID) Algorithm
Authors: Apsada Satria , Risfendra Risfendra
Published: September 2024

Robot Automated Guided Vehicle (AGV) pada umumnya dapat bergerak secara autonomous dan manual. Kendali manual robot Automated Guided Vehicle (AGV) dibutuhkan ketika kendali autonomous sedang tidak digunakan. Kebutuhan untuk kontrol manual pada AGV dapat disebabkan oleh kegagalan sistem otomatis atau untuk situasi di mana operator perlu intervensi langsung untuk keamanan atau tugas yang memerlukan keputusan manusia. Tetapi dalam pengendalian manual robot memiliki nilai deviasi terhadap gerak lurusnya, sehingga mempengaruhi kinerja robot dan menjadikannya semakin sulit dikendalikan. Tujuan penelitian ini untuk meningkatkan performa sistem kontrol manual robot Automated Guided Vehicle (AGV) dengan menggunakan algoritma PID (Proportional Integral Derivative) metode Ziegler Nichlos I atau metode kurva reaksi yang mampu menghasilkan nilai tuning dengan praktis sehingga robot AGV dapat melakukan gerak lurus dengan akurasi yang lebih baik. Penelitian ini terdiri dari tahapan analisis, pengodean dan pengujian robot. Pada penelitian ini menggunakan sensor rotary encoder dengan motor DC PG45 dan dikendalikan mikrokontroler Arduino Atmega 2560 serta kontroler joystick wireless. Penggunaan kendali manual digabungkan dengan Algoritma PID metode Ziegler-Nichols I dengan nilai Kp=0,45; Ki=0,3 dan Kd=0 untuk Motor 1 dan Motor 2 dengan nilai Kp=0,5; Ki=0,15 dan Kd=0 yang dikombinasikan dengan sensor rotary encoder. Hasil pengujian menunjukkan peningkatan kinerja kendali robot AGV dengan nilai ketepatan jarak tempuh dari 3(tiga) meter menjadi 12(dua belas) meter gerak dapat mendekati lintasan lurus.
Analysis of 5G Capacity in Line-Of-Sight Condition of Urban Macro (UMa) Using 3.5 GHz Frequency
Authors: Yaser Muhammad
Published: September 2024

This study is projected to be the initial design for the implementation of 5G technology, particularly in the Urban Macro (UMa) scenario, with a frequency of 3.5GHz and a bandwidth of 100 MHz. 3GPP (3rd Generation Partnership Project) TR 38.901 recommends performing performance analysis with line-of-sight (LOS) situations using the propagation model urban macro (uMa). In this study, 100 users are distributed at random distances to examine system capacity using the frequency reuse factors K = 1/3 and K = 1/7. According to the calculation results, this study demonstrates that system capacity is dependent on user distribution arrangement and the frequency reuse factor approach used. A high frequency reuse factor increases bandwidth efficiency and yields more optimum capacity. Furthermore, distributing users near the base station will boost capacity.
Research trends of digital transformation in healthcare systems: A bibliometric approach
Authors: Zulkifli Zarina
Published: September 2024

This study aims to guide future research by examining trends and structures in scholarly publications about digital transformation in healthcare. We analyzed English-language, open-access journal articles related to this topic from the Scopus database, irrespective of publication year. Using tools like Microsoft Excel, VOSviewer, and Scopus Analyzer, we found a growing research interest in this area. The most influential article, despite being recent, has been cited 836 times, indicating its impact. Notably, both Western and Eastern countries contribute significantly to this field, with research spanning multiple disciplines, including computer science, medicine, engineering, business, social sciences, and health professions. Our findings can help policymakers allocate resources to impactful research areas, prioritize multidisciplinary collaboration, and promote international partnerships. They also offer insights for technology investment, implementation, and policy decisions. However, this study has limitations. It relied solely on Scopus data and didn’t consider factors like author affiliations. Future research should explore specific collaboration types and the ethical, social, policy, and governance implications of digital transformation in healthcare.
Syn vivo encrustation of Porambonites Pander, 1830 (Brachiopoda) by craniid brachiopods in the Late Ordovician of Estonia
Authors: Vinn Olev , Isakar Mare , Almansour Mansour I. , Farraj Saleh Al , Hedeny Magdy El
Published: September 2024

Two new brachiopod–brachiopod symbiotic overgrowths have been discovered from the Kukruse Regional Stage (Sandbian, Ordovician) of Estonia. Both the Philhedra rivulosa–Porambonites sp. and the Petrocrania sp.–Porambonites sp. overgrowths were beneficial to the encrusting craniid and might have been slightly harmful to the host brachiopod. The craniids could have been facultative kleptoparasites. Our data show that craniids significantly preferred the smooth shells of Porambonites sp. over the coarsely ribbed shells of Platystrophia sp. and the moderately ribbed shells of Cyrtonotella sp. and Glossorthis sp. This suggests that, at least against craniids, having strong ribs could have been a successful antifouling strategy.
The influence of the metal phase of novel Al2O3/TiO2/TiAl2O5 composites obtained via a slip casting method
Authors: Wachowski Marcin , Zygmuntowicz Justyna , Kosturek Robert , Śnieżek L. , Piotrkiewicz P. , Żurowski Radosław , Korycka Karolina
Published: September 2024

This study aims to analyze the ceramic-metal composite Al2O3/TiO2/TiAl2O5 obtained using the slip-casting method. Samples containing 50% vol. of the solid phase and 2% vol. and 4% vol. fractions of the metallic phase were examined. Rheological investigations were performed. Measurements of shrinkage and density of the composites produced were determined. The phase composition of the obtained composite was investigated using SEM/EDS and XRD techniques. Stereological analysis was performed as well. The slip-casting method enables the production of the proposed composite, reinforced by the presence of TiO2 and TiAl2O5. With the increase in the content of the metallic phase in the composite, the thialite phase content increases, but the relative density and volumetric shrinkage of the obtained composites decrease. Thialite grains are characterized by a size in the range of 4 µm to 15 µm, which leads to a low density of the samples. The results revealed that no significant effect of changing the metal phase content of the slurries used for fabricated composites was observed on the limiting grain growth of alumina during the sintering process of slip-casting composites. This finding is important as it suggests that the increase in metallic phase content does not lead to undesirable grain coarsening, which could degrade mechanical properties.
Metadiscursive Boosting in Russian Courtroom Discourse: Enhancing Persuasiveness in Defense Speeches
Authors: Boginskaya O. A.
Published: September 2024

Recent studies are revealing new aspects of courtroom discourse, examining its generation and applying novel analytical methods. Yet, despite their significance and complexity, the use of metadiscursive tools remains scarce. These tools offer substantial promise for analyzing discursive practices, increasingly seen as not just informative but also interactive and impactful. The inherently interactive and persuasive nature of courtroom discourse underscores the need for metadiscourse as a potent analytical instrument. Such an instrument encompasses mechanisms for expressing attitudes toward the propositional content and for drawing the recipient into a dialogue with the speaker. This article addresses the metadiscursive dimension of defense speeches as a distinct genre within courtroom discourse. The study uses quantitative analysis on a corpus of Russian-language courtroom texts, innovatively applying metadiscursive analysis to identify linguistic elements that enhance the persuasiveness of defense speeches, with a focus on the technique of boosting. Throughout the study, five types of boosters were identified – markers of certainty, evidentiality, intensity, solidarity, and superiority – each serving one of five pragmatic functions: to show the speaker’s confidence in the truth of their assertions, to point to the credibility and reliability of the source, to amplify the emotional impact of the statement, to denote the upper bounds of a continuum, and to reference commonly known facts or shared experiences of events or situations. The study reveals that boosting at the lexical level is predominantly achieved through the use of evidential verbs and nouns, adverbs of measure, degree, and time, as well as superlative adjectives. Additionally, the frequent use of first-person plural pronouns was observed. The findings suggest that adept use of boosters in courtroom discourse is indicative of a lawyer’s pragmatic competence and is crucial for effective communication with the court and the jury.
Contribution to Threat Management Through the Use of AI-Based IDS
Authors: Saadi Chaimae , Belghiti Imane Daha , Atbib Souad , Radah Tarek
Published: September 2024

Objectives: This paper aims to enhance cybersecurity through the integration of Artificial Intelligence (AI) in Intrusion Detection Systems (IDS), addressing the limitations of traditional IDS in detecting evolving cyber threats.
 
Theoretical Framework: The study builds on existing research in cybersecurity, focusing on AI techniques such as decision trees and linear regression to improve the accuracy and effectiveness of AI-based IDS.
 
Method: A comprehensive review of current AI-IDS methodologies is conducted, alongside an exploration of machine learning algorithms applied to datasets like KDD99 and NSL-KDD. The proposed architecture utilizes supervised machine learning to predict anomalies in network traffic.
 
Results and Discussion: The findings indicate that AI-IDS can significantly reduce false positives and enhance detection of zero-day attacks through adaptive learning. The results highlight the importance of quality data and continuous model refinement.
 
Research Implications: This research underscores the necessity for ongoing exploration of AI techniques in cybersecurity, suggesting future studies focus on real-time adaptive systems to further improve threat detection.
 
Originality/Value: This paper contributes to the field by providing insights into the practical application of AI in IDS, offering a structured approach that combines theoretical knowledge with empirical evidence, thus paving the way for future innovations in cybersecurity.
Оценка влияния технологических параметров процесса распылительной грануляции эмульсий в псевдоожиженном слое на физические характеристики гранул на примере производственного процесса получения кормового витамина А
Authors: Марченок Максим Валерьевич , Рочин Егор Олегович , Пентехина Юлия Константиновна , Сенотрусова Тамара Алексеевна , Сидоренко Андрей Владимирович , Куприянов Николай Алексеевич
Published: September 2024

The paper describes the results of experiments on determining the dependencies between the technological parameters of the spray drying process and the physical characteristics of granules during the process of producing encapsulated vitamin A feed. During the work, the influence of the parameters of the emulsion feed rate and the spray nozzle rotation speed on the size and residual moisture content of the granules was revealed. It was found that the parameters of the air temperature supply intensity significantly affect the residual moisture content and bulk density of the granules. Among the studied parameters, the parameter of the technological air temperature has the greatest impact on the morphology and structure of the granules: increased air temperature leads to swelling and disruption of the proper structure of the granules.
Assessing psychological implications in children with delayed verbal communication and vocabulary development: a systematic review
Authors: Aloudah Muneera
Published: September 2024

Background: Delayed verbal communication and vocabulary development can significantly impact children's emotional well-being, social interactions, and overall psychological development. This systematic review aims to synthesize existing research on the psychological effects associated with these delays, focusing on how they affect children's emotional health, social skills, and cognitive functioning.
Methodology: This review systematically analyzed studies that investigated the psychological consequences of delayed verbal communication and vocabulary development in children. The studies included were diverse in design, including cross-sectional, longitudinal, and mixed-method approaches. Key measures across studies included assessments of depressive and anxiety symptoms, social-emotional functioning, language skills, and cognitive abilities. The analysis synthesized findings from a range of populations, including children with developmental language disorders (DLDs), specific language impairment (SLI), and autistic spectrum disorders (ASDs).
Results: The review found that children with delayed verbal communication and vocabulary development are at increased risk for a variety of psychological issues. These include higher levels of anxiety and depression, difficulties in social interactions, and cognitive challenges. Specifically, children with DLD and SLI were more likely to experience emotional difficulties, such as depressive symptoms and anxiety, compared to their peers. Pragmatic language difficulties were found to be particularly associated with later psychotic experiences and depressive symptoms. Peer problems, bullying, and socioemotional challenges were prominent among youth with language impairments. Additionally, deficits in higher order language skills and cognitive abilities were linked to greater emotional and social difficulties.
Conclusion: The psychological impacts of delayed verbal communication and vocabulary development are profound, affecting children's emotional well-being, social interactions, and cognitive development. Interventions should address both language difficulties and associated emotional and social challenges.
Stolen gametes and mereorganic continuity
Authors:   Lomonosov Moscow State University, Morozov K. E.
Published: September 2024

The article is a commentary on the work of Roman Kochnev Teletransporter and Other Troubles, which is a critical remark on the work of Alexey Kardash Teletransporter and Origami. First, the article reconstructs Kardash’s argument against survival in Parfit’s teletransporter, as well as Kochnev’s criticism. Next, the principle of mereorganic continuity proposed by Kardash is defended as a condition for the survival of the person. To answer Kochnev’s criticism, examples of stolen gametes are simulated, which demonstrate that mereorganic continuity is a detector of causal relationships necessary for the survival of the person. The article concludes by addressing the problem of the implicit dualism inherent in Parfitian views on survival in teletransporter.
Prisoners of World War I in the Omsk Irtysh region: names, statuses, memory
Authors:   Institute of History and Archeology of the Ural Branch of the Russian Academy of Sciences, Surzhikova N. V.
Published: September 2024

The publication does not simply review the inter-fonds name index of prisoners of World War I mentioned in the metric books of churches in the Omsk region (1914–1920). It is shown how formalized information from metric records can be interpreted from the point of view of both nominative and statistical approaches. It is emphasized that in the light of the data of the reviewed publication, the fate of captured foreigners in Russia ceases to look like non-alternative and predetermined, and the prisoners themselves — only victims of war, victimized objects. The participation of prisoners of war in the life of host communities allows specifying the degree of impact of captivity on the institutions and practices common in provincial Russia, as well as considering captured foreigners as people whose destinies turned out to be decisive for the destinies of thousands of other people who lived yesterday and live today.
O impacto sistêmico das alterações da microbiota intestinal em doenças autoimunes
Authors: Cabeda Rafaela , Gadini Ana Clara Bosa , Fauth Bruno Vinícius , Fucina Carolina Radaelli , Lorenzatto Estela Anzolin , Schneider Gabriele de Oliveira , Andreola Isabele Karkow , Poglia Manuela Loeff , Kolling Maria Eduarda , Alves Gabriel Cabeda Spalding
Published: September 2024

Objetivo: Elucidar as repercussões que as alterações da microbiota intestinal acarretam no processo fisiopatológico das doenças autoimunes. Revisão bibliográfica: A microbiota é o conjunto de microorganismos que vivem nos intestinos humanos, representada por trilhões de bactérias, figurando número 10 vezes maior do que a quantidade de células humanas que compõem o corpo humano. Essa entidade estabelece complexas relações com o organismo humano, seja produzindo substâncias diversas; seja competindo por recursos, contra potenciais patógenos; ou seja, interagindo com o sistema imunológico. Nesse contexto, alterações dessa microbiota podem causar desequilíbrios nessas complexas interações, podendo trazer prejuízo ao organismo, sendo demonstrado, neste artigo, sobre o pano de fundo de doenças como diabetes mellitus tipo 1, artrite reumatóide, esclerose múltipla, lúpus eritematoso sistêmico e doença celíaca. Considerações finais: Investigar e compreender melhor essas relações entre microbiota e doenças autoimunes abre caminho para novas estratégias de tratamento e de prevenção de doenças, potencialmente melhorando a qualidade de vida dos pacientes afetados por essas condições complexas.
Therapeutic agents for Hailey-Hailey disease: A narrative review
Authors: Sardana Kabir , Bansal Abhinav , Muddebihal Aishwarya , Khurana Ananta
Published: September 2024

Hailey–Hailey disease (HHD) is an autosomal dominant genetic disorder of keratinocyte adhesion. It occurs due to mutations in ATP2C1, a gene on chromosome 3q21-24 which encodes human secretory pathway Ca2+/Mn2+ ATPase isoform 1, a calcium pump on the Golgi apparatus membrane. Recently, there has been a focus on certain pro-inflammatory cytokines such as IL-6 and IL-8 which play a role in HHD. Various triggers include excessive heat, menstruation, pregnancy, sweating, friction, exposure to sunlight and superﬁcial infections. The therapy of the disorder is better understood by the varied pathogenetic steps and we aimed to comprehensively search for the various medical therapies used in HHD and align them with the existing knowledge on the pathogenesis and delineate them according to their major mode of action.
Analysis of battery-like and pseudocapacitive ion intercalation kinetics via distribution of relaxation times
Authors: Malik Yoga Trianzar , Braig Michael , Simon Patrice , Zeis Roswitha , Fleischmann Simon
Published: September 2024

Improving the kinetics of electrochemical ion intercalation processes is of interest for realizing high-power electrochemical energy storage. This includes classical battery-like intercalation and pseudocapacitive intercalation processes with a capacitor-like electrochemical signature. Electrochemical methods are needed to probe the kinetics of such complex multistep processes in detail. Here, we present the use of the Distribution of Relaxation Times (DRT) analysis of electrochemical impedance data to identify the kinetic limits of intercalation reactions. We study the lithium intercalation reaction in TiS2 from organic and aqueous electrolytes as a model system. The material can exhibit both battery-like and pseudocapacitive intercalation regimes depending on the potential range, variable diffusion lengths by adjusting its particle size, and a tunable degree of solvent cointercalation by choosing the electrolyte solvent. Using DRT, we can distinguish between the kinetic limitations imposed by solid-state ion diffusion, interfacial ion adsorption and transport, and ion desolvation processes. Thus, DRT analysis can complement existing methods, such as voltammetry or 3D-Bode analysis, to better understand the kinetics of intercalation reactions.
DFT-Informed Stereo-Differentiating Asymmetric Rh(I)-Catalyzed Pauson−Khand Reaction: An Approach to Thapsigargin Stereoisomers.
Authors: Haghighi Fatemeh , Jesikiewicz Luke , Stahl Corrinne , Nafie Jordan , Ortega-Vega Amanda , Liu Peng , Brummond Kay
Published: September 2024

We report a stereo-differentiating dynamic kinetic asymmetric Rh(I)-catalyzed Pauson–Khand reaction, which provides access to an array of thapsigargin stereoisomers. Using catalyst-control, a consistent stereochemical outcome is achieved at C2—for both matched and mismatched cases—regardless of the allene-yne C8 stereochemistry. The stereochemical configuration for all stereoisomers was assigned using vibrational circular dichroism (VCD) and 13C NMR. DFT computational results corroborate experimentally observed stereoselectivity, and the corresponding transition state structures identify key stabilizing and destabilizing interactions between the chiral ligand and allene-yne PKR substrates. The robust nature of our catalyst-ligand system places the total synthesis of thapsigargin and its stereoisomeric analogs within reach.
Realization of a photoelectrochemical cascade for the generation of methanol, a liquid solar fuel
Authors: Chan Thomas , Kong Calton J. , Rome Grace A. , Collins Darci , King Alex J. , Prabhakar Rajiv R. , Collins Sarah A. , Young Michelle S. , Wilson Mickey J. , Steiner Myles A. , Tamboli Adele C. , Warren Emily L. , Kubiak Clifford P. , Ager Joel W. , Greenaway Ann L.
Published: September 2024

Biochemical networks use reaction cascades to achieve selectivity, suggesting a route to improve selectivity of photoelectrochemical carbon dioxide reduction (PEC CO2R). We report the co-design and implementation of a two-step photoelectrochemical cascade to a liquid solar fuel: reduction of CO2 to CO and subsequent reduction of CO to methanol. The potentials required were generated using custom-made III-V-based three-terminal tandem (3TT) solar cells. Cobalt phthalocyanine immobilized on multi-walled carbon nanotubes catalyzed both reactions. The champion integrated photocathode produced methanol with 3.8% Faradaic efficiency (FE), with tested photocathodes having 0.7-3.8% methanol FE. Methanol production ceased when the 3TT subcell driving CO reduction was deactivated, supporting the assignment of a cascade mechanism. The low methanol yield is attributed to insufficient CO flux to, and CO2 depletion at, the methanol-producing subcell. Prospects for increasing product yields are discussed. This work develops the basic science principles underlying the PEC CO2R cascade, demonstrates the co-design of a 3TT-based photoelectrode to produce carbon-based fuels, and finally discusses routes for the further development of this concept.
Historia y memoria del puente de Piedra, Lima
Authors: Aguirre Diana
Published: September 2024

La gestión del patrimonio histórico inmueble de la ciudad de Lima, en especial de su Centro Histórico, ha tomado gran relevancia en las últimas décadas, sobre todo a partir de la dación de normativa local alineada con instrumentos legales internacionales suscritos previamente por nuestro país. En ese sentido, la elaboración de planes de gestión o planes maestros establecen lineamientos y estrategias con el fin de preservar, conservar y gestionar de manera sostenible el patrimonio cultural. Es allí donde la investigación histórica desempeña un papel fundamental en la elaboración de estos documentos de gestión, puesto que se convierte en un componente clave para comprender la evolución, valores y características del patrimonio cultural a lo largo del tiempo, asegurando su conservación a largo plazo y su adaptación a las necesidades contemporáneas sin comprometer su identidad histórica y cultural. Siguiendo esta línea, el presente artículo testimonia los cambios que ha sufrido una de las edificaciones emblemáticas de la ciudad de Lima, el puente de Piedra, conocido también como el puente de Montesclaros o puente Trujillo, que conecta a las zonas monumentales de Lima y el Rímac en el Centro Histórico de nuestra capital.
FORMULATION AND EVALUATION COMBINATION OF CARBOPOL/HPMC POLYMER GELS CONTAINING OFLOXACIN FOR OCULAR DRUG DELIVERY SYSTEM
Authors: Ramesh Yerikala , Penabaka Venugopalaiah , Reddy Bommalapuram Veerendra , Raani Chigili Jansi , Ramya Perugumi , Shahistha Syed , Umadevi Vadlapalli , Chandra YadalaPrapurna
Published: September 2024

The current research focuses on assessing hydrochloride/HPMC polyethylene blends for uveitis drug delivery. Processes involving polypropylene (PP) matrices have shown similar behavior to solid lipid nanoparticles, with fluid sub-assemblies playing a larger role. Nanoemulsions, with long-chain structures, link drug dispersibility and rheology. The correct combination of polymer matrices is essential for designing an effective ocular drug delivery system.Further studies suggest that polypropylene enhances self-organization, while HPMC K100 improves drug dissolution and viscosity, particularly in formulations involving narcotics. A blend of three polymers has demonstrated effects on drug dissolution, dispersibility, and viscosity.Nanoemulsion-based formulations have shown the best results for drug dissolution and decent rheological properties. Cultured cell investigations indicate that higher levels of specific plastics improve dosage forms. Overall, this research emphasizes the importance of polymer selection and formulation in optimizing drug delivery for uveitis treatment.
Indictment: current issues of form and content
Authors:   Institute of State and Law RAS, Rossinsky S. B.
Published: September 2024

The results of the next stage of the author’s scientific research, devoted to indictments as law enforcement acts that complete pre-trial proceedings in criminal cases and predetermine their referral to the courts for consideration on the merits, are summed up. Attention is drawn to rather destructive approaches to the form and content of indictments that have emerged due to a number of reasons, which complicate the law enforcement practice of preliminary investigation bodies, lead to an imbalance of procedural functions, and an unreasonable balance of investigative, prosecutorial and judicial powers. In addition, it is said that these approaches do not correspond to the true purpose of indictments, and therefore attention is drawn to the need for the development, introduction to the subject of criminal procedural regulation and the gradual introduction into law enforcement practice of new approaches to the preparation of these documents.
Macroprudential regulation in the EU and the EAEU: an organizational and legal mechanism
Authors:   Moscow State Institute of International Relations (University) of the Ministry of Foreign Affairs of the Russian Federation, Valiev T. M.
Published: September 2024

The comparative legal analysis is focused on the system of legal regulation of macroprudential regulation and supervision of the European Union (the “EU”) financial system and the regulation of coordinated macroeconomic policy in the Eurasian Economic Union (the “EAEU”). The significance of the research is explained by the increasing systemic risks in the presence of the structural changes in the international economy. The subject of the research is the key norms of the primary and secondary law of integra-tion associations, which define the key elements of macroprudential (macroeconomic) supervision of integration associations. There is defined the similarity of European regulation with international legal regulation of financial stability, and there are speci-fied similarities and differences of the organizational mechanism of the EU and the EAEU and its capabilities in the context of soft law.
The history of the development of the legal concept “digital state” in Russia
Authors:   Irkutsk Law Institute (branch) of the University of the Prosecutor’s Office of the Russian Federa-tion, Shabaeva O. A.
Published: September 2024

It was established that it was the USSR that was the leader in the development of the theory and practice of the digital state and the digital economy. The “Red Book” projects and the National Automated System were the world’s first projects to create a digi-tal state. It was revealed that the development of the theory and practice of the digital state is based on a powerful foundation laid by Soviet scientists, in the first row of which are A. I. Kitov and V. M. Glushkov. Their projects “Red Book” and OGAS, work on the theory and practice of creating computers, programming, mathematical modeling and the use of computers in various fields of activity, laid the foundations for the development of the digital state and the digital economy and ensured the leadership of the USSR in this area. It is concluded that the concept of the digital state is constantly developing and supplemented by scientists and practitioners. The creation of a digital state in Russia and other countries continues on new technological foundations using new and emerging digital technologies, such as artificial intelligence, big data, blockchain, new production technologies, Internet of things and industrial Internet, virtual and augmented reality, neurotechnology, robotics, sensing, wireless communication, quan-tum technologies. Based on the analysis of the development of the legal concept of the “digital state’ in Russia, a proposal is made to distinguish the following periods: pre-revolutionary (until 1917); Soviet (1918–1992); post-Soviet (1993–2006); modern (2007 – present).
THE IMPACT OF COGNITIVE STIMULATION IN OLDER ADULTS WITH DEMENTIA
Authors: Teixeira Carla M. , T. Ribeiro Paula A. , Vasconcelos-Raposo José
Published: September 2024

This study evaluated the impact of a cognitive stimulation program on older adults diagnosed with dementia. The sample comprised 22 participants aged 73-95, randomly assigned to an experimental group (N = 12) and a control group (N = 10). While no statistically significant decreases were observed in the studied dimensions, clinically relevant gains were noted: 41.70% in cognition, 41.60% in quality of life, and 8.3% in functional skills. Although no therapeutic interventions have successfully reversed dementia, healthcare providers reported improvements in participants’ social interactions, behaviors, and engagement in daily institutional routines. These observations suggest tangible benefits from program participation. It’s important to note that staff working closely with these patients daily observed these improvements despite the lack of statistically significant results. This discrepancy highlights the potential limitations of relying solely on quantitative measures to assess such interventions’ effectiveness. In conclusion, the cognitive stimulation program shows promise as a potential tool for slowing dementia-associated degenerative processes, particularly in areas that standard quantitative assessments may not fully capture. Further research with larger sample sizes and more sensitive measures may be warranted to fully understand the program’s impact.
Cinclidotus pachylomoides Bizot (Bryophyta) Ekstraktının Antidiyabetik Etkisi
Authors: Değirmenci Ulaş , Ezer Tülay
Published: September 2024

Tip 2 diyabet (T2D), 21. yüzyılda tüm uluslarda en önemli halk sağlığı sorunlarından biri olarak kabul edilmektedir. Diyabetin kronik hiperglisemisi, çeşitli organların uzun vadeli hasarı, işlev bozukluğu ve yetmezliği ile ilişkilidir. Postprandiyal hiperglisemi esas olarak bağırsakta glikozun hızlı emiliminden kaynaklanır ve burada α-glukozidaz diyetle alınan karbonhidratların hidrolizinde önemli bir rol oynar. Tip 2 diyabetin tedavisinde α-glukozidaz inhibisyonu etkili bir yaklaşım olarak kabul edilmektedir. Briyofitler, bitkiler aleminin ikinci büyük taksonomik grubu olup biyoçeşitliliğin ayrılmaz bir parçasıdır. Son zamanlarda ciğerotlarından ve karayosunlarından çok sayıda farklı biyoaktif madde izole edilmiştir. Bu çalışmada da GK/KS yöntemiyle ilk kez karakterizasyonu yapılan karayosunu türü Cinclidotus pachylomoides Bizot (Bryophyta) ekstraktının α-glukozidaz enzim inhibisyon etkisi araştırılmış olup orta düzeyde α-glukozidaz enzim inhibisyon etkisi olduğu tespit edilmiştir.
On the Road to Electoral Democracy? Erosion of the Free and Fair Elections Standard in the Era of the Polish Constitutional Crisis after 2015
Authors: Mistygacz Michał
Published: September 2024

This article attempts to diagnose the state of democracy in Poland, remaining in the era of constitutional crisis and following the erosion of the free and fair elections standard, which determines the criteria for distinguishing an electoral democracy from a liberal democracy. For this purpose, the individual elements constituting this concept are analyzed, both having a procedural dimension and referring to the course of the three phases of the electoral process itself (the period before election day, on election day and after election day), as well as referring to the standards of honesty, reliability, the real possibility of alternative power or equal opportunities. The conclusions drawn at individual stages of the deliberations, including an indication of the destabilisation of electoral law, the erosion of guarantees regarding the reliability of elections, disproportion in the access of political party representatives to public media, lead to a thesis on the formation of electoral democracy in Poland, which can be described as a democratic system devoid of liberal values. It is characterised by restrictions on freedom of association, freedom of speech and academic freedom, electoral distortions, unequal access of representative political parties to the public media and judicial guarantees related to the electoral process.
The Object Protected by the Criminalization of Insult to a Human Corpse in Polish Law
Authors: Najman Michał
Published: September 2024

The insult of a human corpse is one of the oldest crimes. The guarantee of the inviolability of a human body after death, as well as the cult of the deceased are considered a precursors of religious faith. In the early periods of social development, the protection of corpses and burial sites stemmed from the prevailing religious beliefs among community members. Hence, in legal orders, it was religion, religious feelings, worship of the deceased, and others that were the main objects protected by the criminalization of insulting a corpse. To date, such a position remains popular and widely accepted. However, with the progress of civilization, more attention is beginning to be paid to the fact that the legal protection of human corpses is independent of religion. The purpose of the article is to point out the multiplicity of definitions of the object protected by the criminalization of insulting a corpse and thereby make the reader aware that both the law and the values cultivated in society are dynamic institutions. This will make lawyers aware that their activity should not only focus on passive acceptance and repetition of the established truths and values, but also prompt them to figure out new ones or to search for new justifications that are more suitable in the current reality.
Essential Elements of the Democratic Rule of Law as an Expression of Constitutional Identity in the Czech Constitution
Authors: Tomoszek Maxim
Published: September 2024

The present article consists of two parts. The first part focuses on the concept of constitutional identity in a general comparative perspective and its connection with constitutional philosophy. In the second part, these premises are applied to the Constitution of the Czech Republic, specifically its core values denominated by the Czech Constitution as the essential elements of the democratic rule of law in order to analyze whether they can be used to define Czech constitutional identity and what specific principles constitute the constitutional identity of the Czech Constitution.