MEDICAL MANAGEMENT OF THE COMPLICATIONS OF EARLY PREGNANCY WITH MISOPROSTOL
Authors: Nuzhat Amin  , Himasa Gull  
Published: June 2024

OBJECTIVE: The study’s goal was to ascertain if misoprostol is beneficial for people who have early pregnancycomplications. And to prevent these individuals from undergoing surgical evacuation.METHODOLOGY: Between 2015 and 2017, an experimental investigation was carried out at the MardanMedical Complex Hospital in Mardan at the Department of Obstetrics and Gynecology, Unit A. For misoprostoltherapy, 200 women with early pregnancy problems were included. Patients with early pregnancy problems who werehemodynamically stable and had a gestational age of fewer than 15 weeks met the inclusion criteria. Patients having ahistory of ectopic pregnancy, gestational trophoblastic illness, hemodynamic instability, uterine rupture, hypersensitivityto prostaglandin, and hemoglobin levels below 9 g were excluded. The ability to successfully resolve miscarriages withoutthe need for surgery was the primary outcome measure. Incidence of discomfort, vaginal bleeding, infection, pyrexia,and adverse gastrointestinal symptoms were secondary outcomes. The research included 200 women in total. They wereprimigravida to grand multigravida, ranging in age from 16 to 45. Thirty (15%) had an embryonic pregnancy, 88(44%) had an incomplete abortion, and 82 (41%) had an early fetal death. When misoprostol was the only medicationused for therapy, 140 (or 70%) women entirely expelled the conceptual products; nevertheless, 60 (30%) patients neededsurgery since their conceptual products had not been fully expelled and they were bleeding excessively. The average timebetween induction and expulsion was 16 hours. The most common adverse effects reported were diarrhea, vomiting,pyrexia, discomfort, and nausea. In 14 individuals, more than one side event was reported. For individuals with earlypregnancy difficulties, misoprostol is an appropriate and effective treatment for early pregnancy loss. It may be kept atroom temperature and is inexpensive and heat stable.RESULTS: The study concerned a diverse institution of women, starting from primigravida to grand multigravida,and spanning a while sixteen to 45. The distribution of pregnancy headaches covered 15% with embryonic pregnancy,44% with incomplete abortion, and 41% with early fetal demise. Out of the 2 hundred girls, one hundred forty (70%)effectively expelled the conceptual products solely through misoprostol therapy. However, 30% of sufferers requiredsurgical operation because of incomplete expulsion and excessive bleeding. The common time between misoprostolinduction and complete expulsion changed into reported as sixteen hours.The look at additionally referred to notunusual adverse consequences, such as diarrhea, vomiting, pyrexia, pain, and nausea. In some instances, a couple ofside impact became reported, affecting 14 people.CONCLUSION: The observe contributes treasured insights into the scientific management of early pregnancycomplications using misoprostol. It emphasizes the effectiveness of misoprostol in resolving miscarriages without theneed for surgery in a significant proportion of instances. The documented negative consequences, while present, shouldbe weighed towards the blessings of averting surgical processes.KEYWORDS: Misoprostol, medical treatment, miscarriage.