bluuebunny/crossref_metadata_2025 huggingface dataset:
Gastroesophageal Adenocarcinomas With Defective Mismatch Repair: Current Knowledge and Clinical Management
Authors: Strickland Matthew R. , Lander Eric M. , Gibson Michael K. , Ilson David H. , Ajani Jaffer A. , Klempner Samuel J.
Published: March 2024

Esophageal, gastroesophageal junction, and gastric adenocarcinomas, referred to collectively as gastroesophageal adenocarcinomas (GEAs), are a major cause of global cancer-related mortality. Our increasing molecular understanding has led to the addition of biomarker-directed approaches to defined subgroups and has improved survival in selected patients, such as those with HER2 and Claudin18.2 overexpression. Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer, including GEA, but biomarkers beyond PD-L1 expression are lacking. Mismatch repair deficiency and/or high microsatellite instability (dMMR/MSI-H) is observed in 8% to 22% of nonmetastatic GEA, and 3% to 5% of patients with metastatic disease. dMMR/MSI-H tumors are associated with more favorable prognosis and significant benefit from ICIs, although some heterogeneity exists. The activity of ICIs in advanced dMMR/MSI-H cancer is seen across lines of therapy and should be recommended in the frontline setting. In patients with nonmetastatic dMMR/MSI-H cancer, increasing evidence suggests that perioperative and adjuvant chemotherapy may not provide benefit to the dMMR/MSI-H subgroup. The activity of perioperative chemotherapy-free immune checkpoint regimens in patients with nonmetastatic dMMR/MSI-H cancer is highly promising and underscores the need to identify this unique subgroup. We recommend MMR/MSI testing for all patients with GEA at diagnosis, and review the key rationale and clinical management implications for patient with dMMR/MSI-H tumors across disease stages.
Relationship between physical exercise load and return-to-work in female breast cancer survivors
Authors: Carrión Gilabert Hector , Arbós Figueras Judith , Matas Sergi , Anzano Antoni , Mas-Alòs Sebastià
Published: March 2024

Introduction: Evidence has shown physical exercise leads health benefits in breast cancer survivors, for example reducing return-to-work (RTW) time. However, what exercise component has (if any) the greatest impact on the recovery time after breast cancer. The aim of this study is to determine the exercise load variables (type, frequency, intensity, exercise time, volume, density and progression) that are best associated with recovery time in female breast cancer survivors (measured as time off work). Methods: In this systematic review, we included experimental, cohort, and observational studies of female breast cancer survivors engaging in physical exercise programs. We searched PubMed, Web of Science, Sport Discus, and Scopus (Sep 2021-Sep 2022) using the PICOS strategy and PRISMA 2020 guidelines. Studies were independently screened and data extracted into a database, focusing on exercise variables association with return-to-work time. Methodological quality was assessed using ROB 2.0, considering study design, intervention details, and bias risk. Results: Following screening, seven studies were included in this review, with five defining a minimum of one exercise component. Two studies specified frequency and density, while three defined the type, frequency, volume, intensity, density, and progression of interventions. No study found a direct correlation between exercise components and RTW time. Conclusions: In the literature reviewed in this systematic review, it is not possible to identify which exercise variable(s) have the strongest correlation with RTW outcomes. The existing studies demonstrate a lack of comprehensive intervention descriptions, limiting our understanding of the distinct exercise components and their potential effects on RTW results.
Aspiring for More: Deeper Partnerships for Sustainable Teacher Residencies
Authors: Paull Zachary , Mansukhani Divya , DeMoss Karen
Published: March 2024

Sharing partnership-focused learning across 12 teacher residency partnership sites during the 2019-2020 school year, Prepared To Teach reports on the development and co-constructed activities facilitated in its National Learning Network. These include highlights in six areas: sustainability, partnership development, program redesign, supporting school improvement, mentor development, and resident learning.
The Challenge of Cultural Diversity in Regional Integration: A Comparative Analysis of the EU and ASEAN
Authors: Wang Caiyan
Published: March 2024

With the trend towards globalisation and increasing economic, political and cultural interconnectedness, the need for regional integration has become more pressing. However, cultural differences between member states, including differences in ethnicity, background and values, often pose an obstacle to regional integration. The European Union (EU) and the Association of Southeast Asian Nations (ASEAN) are two very important regional organisations, although they both aim to promote regional integration and thereby develop regional economies and provide the region with international competitiveness. However, the different historical backgrounds, economic structures and political formations between the two regions have led to different models and objectives for regional integration, and thus the challenges of cultural diversity are similar as well as different in many ways. With the trend towards globalisation and the prominence of cultural diversity issues in the region, comparing the challenges and opportunities of cultural diversity in the regional integration process between the EU and ASEAN, both regions, helps to provide a more comprehensive understanding of the different models of regional integration and why policies related to cultural diversity need to be tailored, rather than copied, to the local context.
Pemberian Edukasi Pertolongan Pertama pada Luka Bakar di RW 08 Kelurahan Sepanjangjaya Kota Bekasi
Authors: Arabta Malem Peraten Pelawi  , Dinda Nurfajri Hidayati Bunga  , Ernauli Meliyana  , Roulita  , Baltasar Dedu  , Mardinata
Published: March 2024

Luka bakar telah menjadi masalah kesehatan masyarakat global yang menyababkan kematian sekitar 180.000 orang per tahun yang diakibatkan oleh luka bakar. Angka kejadian pada tahun 2012 sejumlah 1.187 kasus, pada tahun 2013 menurun menjadi 1.123 kasus dan meningkat pada tahun 2014 terdapat 1.209 kasus. Pravelensi tertinggi luka bakar terdapat di provinsi Papua (2.0%) dan Bangka Belitung (1.4%). Hasil penelitian ada perbedaan sebelum dan sesudah dilakukan kesehatan hasil analisa dengan menggunakan paired sampel t-test dalam hasil P value (0,000) < alpha (0,05). Dapat disimpulkan ada pengaruh setelah dilakukan pendidikan kesehatan terhadap pengetahuan masyarakat tentang pertolongan pertama pada luka bakar.
Mewujudkan Generasi Emas dengan Optimalisasi Bounding Attachment Melalui Pijat Bayi oleh Ibu & Kader Posyandu di Kelurahan Sepanjang Jaya Kecamatan Rawalumbu, Bekasi
Authors: Wiwit Desi Intarti  , Evi Nur Akhiriyanti  , Lenny Irmawaty  , Puri Kresna Wati  , Farida Simanjutak  , Renince Siregar  , Hainun Nisa  , Tetty Rina Aritonang  , Marni Br. Karo  , Riyen Sari Manullang  , Friska Junita  , Rupdi Lumban Siantar  , Dewi Rostianingsih  , Maslan Pangaribuan  , Siti Munawaroh  , Siti Munawaroh
Published: March 2024

Pertumbuhan dan perkembangan anak merupakan hal yang sangat penting dan salah satu aspek yang harus diperhatikan secara serius sejak usia dini. Upaya yang dapat dilakukan dalam mengoptimalkan di samping nutrisi yang diberikan oleh ibu dan salah satu cara lain perlu adanya rangsangan stimulus pijat bayi. Metode kegiatan pengabdian masyarakat dilakukan dengan cara melakukan pendidikan kesehatan dan praktik mengajarkan  pijat bayi untuk optimalisasi bounding attachment ibu dan bayi serta ketrampilan seputar pijat bayi dan memberikan edukasi mengenai manfaat pijat bayi. Bertempat di Kelurahan Sepanjang Jaya Kecamatan Rawalumbu dan waktu pelaksanaan bulan Desember 2022. Hasil kegiatan terjadi peningkatan Pengetahuan Ibu sebelum dan sesudah Pendidikan Kesehatan dan Mempraktikan Pijat Bayi Optimalisasi Bounding Attachment. Pengetahuan definisi, tujuan dan manfaat pijat bayi hasil pretest sebanyak 60% peserta menyatakan jawaban benar, hasil posttest sebanyak 100% peserta menyatakan benar. Pengetahuan tentang indikasi dan kontraindikasi pijat hasil pretest sebanyak 36,7% peserta menyatakan jawaban benar, hasil posttest sebanyak 96,5% peserta menyatakan benar. Pengetahuan persiapan yang dilakukan pijat bayi hasil pretest sebanyak 53,3% peserta menyatakan jawaban benar, kemudian hasil postest sebanyak 97% peserta menyatakan benar. Pengetahuan prosedur dan tata cara pijat bayi hasil 33,3% peserta menyatakan jawaban benar, kemudian hasil posttest 100% peserta menyatakan benar. Pijat bayi sebagai aplikasi stimulasi sentuhan, karena dalam pijat bayi terdapat unsur sentuhan berupa kasih sayang, perhatian, suara atau bicara, pandangan mata, gerakan, dan pijatan.
Kombinasi Aromaterapi Jahe dan Akupresur Titik P6 dalam Mengurangi Emesis Gravidarum
Authors: Melati Dwi Putri  , Rupdi Lumban Siantar  , Tetty Rina Aritonang  , Farida Simanjuntak  , Maslan Pangaribuan  , Marni Br Karo
Published: March 2024

Selama kehamilan, mual di pagi hari merupakan gejala umum yang dialami  banyak ibu. Gejala ini biasanya muncul pada trimester pertama kehamilan dan bisa terjadi kapan saja, meski seringnya terjadi di pagi hari. Upaya pencegahan dengan menggunakan pengobatan tradisional atau menggunakan terapi komplementer seperti aromaterapi jahe dan akupresur  P6. Tujuan dari kegiatan pengabdian masyarakat yang dilakukan adalah Meningkatkan pengetahuan masyarakat mengenai manfaat aromaterapi jahe dan akupresure P6. Pengabdian masyarakat dilakukan dengan metode penyampaian materi menggunakan powerpoint dan pembagian leaflet pada sasaran penyuluhan dan diikuti dengan sesi tanya jawab serta melakukan demonstrasi pemberian aromaterapi jahe dan pemijatan akupresur pada titik P6. Hasil uji pearson menunjukan hasil nilai P > 0,05 berdasarkan hasil analisis antara pengetahuan dan sikap tidak ada hubungan terhadap emesis gravidarum. Disarankan untuk dilakukan promosi kesehatan secara berkelanjutan oleh para kader setempat sehingga semakin banyak warga yang memahami tentang emesis gravidarum dan berupaya untuk melakukan pencegahan hiperemesis gravidarum.
Menjadi Wanita yang Berkualitas, Sehat Organ Reproduksi dengan Memanfaatkan Metode Komplementer di Puskesmas Karang Mulya Kabupaten Bekasi
Authors: Pangaribuan Maslan , Br Karo Marni , Hainun Nisa  , Wiwit Desi Intarti  , Lenny Irmawaty Sirait  , Farida Simanjuntak  , Riyen Sari Manullang  , Dewi Rostianingsih  , Renince Siregar  , Tetty Rina Aritonang  , Puri Kresnawati  , Rupdi Lumban Siantar  , Friska Junita
Published: March 2024

Menjaga kesehatan organ reproduksi merupakan hal yang penting karena terkait dengan bagaimana kita menjamin keberlangsungan hidup manusia dari generasi ke generasi. Masalah kesehatan reproduksi perlu mendapat sosialisasi yang luas agar para calon ibu mengetahui persoalan reproduksi yang akan dialaminya  serta mendapatkan jalan keluar dari persoalan tersebut. Salah satu masalah kesehatan yang menjadi fokus pemerintah dalam    penanggulangan anemia pada remaja putri. Anemia pada masa remaja bisa berakibat hingga masa kehamilan, yang menyebabkan ibu hamil mengalami banyak keluhan selama masa kehamilan seperti timbulnya keluhan ketidaknyamanan. Salah satu latihan yang dapat dilakukan oleh ibu hamil untuk mengurangi rasa kurang nyaman pada tubuh adalah prenatal yoga. Hasil penelitian ada perbedaan sebelum dan sesudah dilakukan pendidikan kesehatan hasil analisa dengan menggunakan paired sample t-test dalam hasil P value (0,000) < alpha (0,05). Dapat disimpulkan ada pengaruh setelah dilakukan pendidikan kesehatan terhadap pengetahuan masyarakat tentang prenatal yoga.
CORRELATIONS BETWEEN FAMILY SUPPORT AND COMPLIANCE LEVELS UNDERGOING INDEPENDENT ISOLATION AS AN EFFORT FOR COVID-19 RECOVERY IN THE WORK AREA OF THE PERWIRA HEALTH CENTER IN 2022
Authors: Uji Awaludin  , Rotua Suriany Dinda Nur Fajri , Rotua Suriany
Published: March 2024

Background: quarantine patients must comply with health protocols. If you don't comply, you can transmit the virus, the isolation period will be longer and the situation will get worse. 211 people who do self-isolation in RW 13 Kelurahan officer. The problem found was in the form of transmission from the accompanying family due to the lack of implementing Health protocols. Family moral or material support is useful so that the patient is not lonely, accepting, enthusiastic and optimistic that he can recover. Good family support can affect the readiness of Covid-19 patients during quarantine so that patients are disciplined. Methods: This study is a quantitative analytical observational study with a cross-sectional approach and purposive sampling technique and uses direct and online questionnaires via googleform to 69 respondents in RT 002, 003, and 008. The chi square test was used to determine the existence of a correlations. Results: Based on the results of the Chi Square test analysis, the p value = 0.000 was obtained. This means that H0 is rejected and H1 is accepted. Conclusion: There is a correlations between family support and the level of compliance with self-isolation in the work area of ​​the Perwira Health Center in 2022.
RISK FACTORS FOR THE OCCURRENCE OF COVID-19 IN PEOPLE WITH TYPE 2 DIABETES MELITUS IN THE COMMUNITY RT 006/002 TELUK JAYA, VILLAGE JAYA, DISTRICT IN 2022
Authors: Sapitri  , Dinda Nur Fajri Hidayati Bunga  , Hilda Meiryandah Agil
Published: March 2024

Background: Based on data from the International Diabetes Federation 2020, the number of diabetics continues to increase in various countries, including Indonesia. The prevalence of diabetes in Indonesia still reaches 6.2 percent with 10,681,400 cases. Diabetes Melitus (DM) is a metabolic disorder disease that affects the work of insulin in glucose absorption. Factors related to the occurrence of COVID-19 in a person with type 2 diabetes Melitus include characteristics consisting of gender, age and Activity Of Daily Living as well as foods that can increase high levels of sugar in the body, this is reviewed from the results of other studies conducted by Smith (2021) in the journal (Apin, 2021).
Research Objectives: This study has a general objective, namely to determine the Risk Factors for the Occurrence of Covid-19 in People with Type 2 Diabetes Melitus in the RT community. 006/002 Teluk Jaya Village, Jaya District, in 2022.
Research Method: The design in this study uses Observational Analytics with a Cross Sectional research design, the sampling technique used in this study is a total sampling with a total sample of 50 respondents in accordance with the inclusion criteria, measured using a digital questionnaire and carried out statistical tests using Chi Square.
Results: Based on the results of the chi square statistical test output obtained.. It can be concluded that the Value of Asymp Significance (0.000) < the value of α (0.05), this indicates that H0 is rejected. Thus, it can be concluded that there is a relationship between ADL and the confirmation of COVID-19 in the COMMUNITY RT006/002 Teluk Jaya Village, Jaya District, Karawang Regency.
Conclusion: Risk Factors for the Occurrence of Covid-19 in People with Type 2 Diabetes Melitus in the RT community. 006/002 Teluk Jaya Village, Jaya District, in 2022.
CORELLATION BETWEEN KNOWLEDGE LEVEL WITH HIV/AIDS PREVENTION BEHAVIOR AT YADIKA 8 JATIMULYA VOCATIONAL SCHOOL IN 2022
Authors: Desnitamutia Desnita Mutia Sari , Rotua Suriany Simamora  , Nurti Y. K. Gea
Published: March 2024

Background: The HIV/AIDS epidemic is a problem in Indonesia which is the 5th most at risk of HIV/AIDS in Asia, reports of HIV cases have increased every year since it was first reported in 1987, the most spike in increase was in 2016 compared to 2015 namely of 10,315 cases.
Researcher's Objective: To find out the relationship between knowledge level and HIV/AIDS prevention behavior in Yadika 8 Jatimulya Vocational High School in 2022
Research Method: This research method is quantitative by using a cross sectional design. The population in this study were 110 teenagers at SMK Yadika 8 Jatimulya consisting of grades 10, 11 and 12 majoring in Accounting, Administration and Computer and Network Engineering. by using simple random sampling technique.
Researcher results: Based on the results of research conducted by researchers at SMK Yadika 8 Jatimulya, the results of data processing using SPSS obtained Chi Square statistical test results, namely the Asymp Significance value (0.000) < value (0.05), this indicates that H0 is rejected. this shows that H0 is rejected. Thus, it can be concluded that there is a relationship between the level of knowledge and HIV/AIDS prevention behavior at SMK Yadika 8 Jatimulya in 2022.
Conclusion: There is a relationship between the level of knowledge with HIV/AIDS prevention behavior in SMK Yadika 8 Jatimulya.
THE RELATIONSHIP BETWEEN WATCHING STRUCTURED CARTOON FILM WITH TODDLER CHILDREN'S SPEECH ABILITY AT RT. 003 RW. 001 CIBITUNG SUB-DISTRICT, WANASARI SUB-DISTRICT YEAR 2023
Authors: Sandia Tiara , Kristiani Gea Nurti Yunika , Simamora Rotu Suriany
Published: March 2024

Background: Age 1-3 years, children at this age have several characteristics in common with the previous period. Physically the child is still experiencing rapid growth. Speech and language skills in early childhood are very important because they are not only a means of communication but also for the growth and development of children. children who since childhood are trained and guided to speak well. Watching structured cartoon films can affect children's speech development. So from watching movies that are structured with sufficient time limits, children will quickly grasp the language in cartoons because these cartoons are interesting spectacles for children. Research Objectives: Knowing the Relationship between Watching Structured Cartoon Films and Speaking Ability of Toddlers in Rt 003 Rw 001 Cibitung District, Wanasari Village Research Methods: The research method used is quantitative, with a research design that is observational analytic and uses a cross sectional approach. The population in this study were toddlers who had good speech skills in Rt 003 Rw 001, Cibitung District, Wanasari Village with a total of 80 children. The data collection technique uses simple random sampling. Research Results: It was found that with a significant level of 95% or an α value of 5% (0.05) the results of the Ci Square test obtained a p value (0.000) <α value (0.05). This shows that H0 is rejected. Conclusion: There is a relationship between watching structured cartoon films and the speaking ability of toddlers in RT 003 RW 001, Cibitung District, Wanasari Village. Keywords: Watching Structured Cartoon Movies, Speaking Ability
THE CORRELATION BETWEEN THE FAMILY SUPPORT WITH ADHERENCE TO A LOW-SALT DIET IN PEOPLE WITH HYPERTENSION AT WAY PANJI PUBLIC HEALTH CENTER IN 2022
Authors: Sonia Ni Wayan Soniawati , Simamora Rotua Suriany , Pelawi Arabta M. Peraten
Published: March 2024

Hypertension is one of the non-communicable diseases that is the most important health problem in Indonesia because of its high prevalence. Management of hypertension can be done by undergoing adherence to a low-salt diet. One of the factors that influence the success of a low-salt diet is the presence of family support. This study aims to determine the family support with adherence to a low-salt diet in people with hypertension at Way Panji Public Health Center, in 2022. The research method used is quantitative with cross-sectional analytic research. The population in this study were people with hypertension 20-70 years old at Way Panji Public Health Center totaling 90 people. The data collection technique used type of simple random sampling based on the inclusion criteria and obtained the number of samples as many as 73 respondents. The results showed that with a significant level of 95% or α value of 5% (0,05) the results of the Chi Square obtained p-value (0,000) < α (0,05). This show that H0 is rejected. The conclusion of the study is a the family support with adherence to a low-salt diet in people with hypertension at Way Panji Public Health Center in 2022.
The Relationship Between Motivation And Application Of Therapeutic Communication By Nursing Students Of Stikes Medistra Indonesia In 2022
Authors: Ghaziah Siti , Simamora Rotua Suriany , Bunga Dinda Nur Fajri Hidayanti
Published: March 2024

Motivation is an impulse from within students to improve their performance and fulfill their needs. One of the basic nursing skills that must be mastered by nursing students is therapeutic communication. Therapeutic communication is a consciously planned communication with its goals and activities focused on healing the patient. There are still many nursing students in taking action the nurse does not introduce themselves first, when measuring vital signs the nurse does not ask the patient's identity first, in administering medication the nurse does not explain what drug will be given to the patient, unless the patient asks. This study aims to determine the relationship between motivation and the application of therapeutic communication by nursing students at STIKes Medistra Indonesia in 2022. The research used is quantitative with cross sectional. The population is 8th semester nursing students of STIKes Medistra Indonesia in 2022 totaling 131 students. Data collection technique using simple random sampling. It was found that with a significant level of 95% or a value of 5% (0.05) the p value (0.004) < value (0.05). There is a Relationship between Motivation and Application of Therapeutic Communication by Nursing Students of STIKes Medistra Indonesia in 2022. There is a Relationship between Motivation and Application of Therapeutic Communication by Nursing Students of STIKes Medistra Indonesia in 2022. Therapeutic communication, motivation and application of therapeutic communication.
Government expenditure and economic growth nexus: How valid is Wagner’s law in the Nigeria situation?
Authors: Joshua Udi , Umar Aishat Princess , Owolabi Ayobami Temitope
Published: March 2024

This study specifically aims at verifying if Wagner’s law is consistent with the Nigerian situation by adopting the ARDL method. Findings from the estimation prove that Wagner’s law is a fallacy in Nigerian experience. In contrast, the Keynesian theory of national income is applicable to the economy of Nigeria, as demonstrated by the strong positive impact of government expenditure on economic growth. Equally important, FDI inflows demonstrate a strong positive relationship with the economic growth of Nigeria. Note that Nigeria went into recession recently and is now going through the recovery stage. This, in line with the findings, calls for the adoption of an expansionary fiscal policy in order to stimulate aggregate demand and, by implication, improve output performance in the economy. Most importantly, the increased government spending should be tailored toward viable sectors with close monitoring to avoid diversion of resources through corruption. Efforts should also be made to attract foreign companies to invest in the economy.
Public and private healthcare administration priorities in new electronic age
Authors: Lordkipanidze Revaz
Published: March 2024

The work defines the such priorities of healthcare administration as creation of free-tax medical town-campuses and reduction of costs for accessibility of medical services, increase in service speed and improvement in the quality, constant process of improving the qualification, wide-regional network management, combination of public and private insurance, essential increase in healthcare costs of GDP, striving for the highest standards of technical level, ensuring the non-profitability of medical organizations, combining various stages of medical services, electronic transparency and direct communication of financial reporting with some needful maintaining of commercial secrets and bank accounts, usage of wide outsourcing practices.
Identifying and prioritizing supply chain risks using the ANP and Dematel Model Process (including case study)
Authors: Tabariyan Hojatollah Shakeri , Taghipour Mohammad
Published: March 2024

Uncertainty is one of the most important challenges in the supply chain that can affect its goals. Therefore, identifying and evaluating risks is of particular importance. If the importance of risks in any industry can be identified, there can be specific measures against them, and the organization can be protected from their damage. Chain risk management can also be a useful approach in organizational and management due to its dynamic nature and the role of the main business functions. Given that the car industry in any country is one of the indicators of development because of its value and special place in industrial production and the after-sales service network, and in terms of its extensive connection to the chains of the previous and later industries, it is a key industry. And it has a high potential for employment and an effective role in economic growth and development. Therefore, this study was devoted to a case study on the supply chain of Iran Khodro Company. The goal is to identify and prioritize the supply chain risks for this company. In this regard, after identifying the effective risks in the supply chain of Iran Khodro Company, according to experts, we used the Dematel-ANP Combined Approach to rank the identified risks and apply the importance of each risk strategy and responsive programs appropriate to them.
Social business, artificial intelligence, and sustainability: An integrated approach for the future
Authors: De Andreis Federico , Comite Ubaldo , M. Gallo Alba , M. Andone Diana , Ciaschi Giacomo
Published: March 2024

The paper scrutinizes the social business model in light of current and impending challenges within the capitalist system. It emphasizes the integration of this model into a civil economy oriented toward public well-being, illustrating how it effectively addresses environmental, social, and economic issues while ensuring economic sustainability. The strategic utilization of Artificial Intelligence (AI) to optimize resources and enhance production efficiency is explored as a pivotal element in achieving sustainable development goals. The article then presents a case study—Madri Leone, a winery in Puglia, Italy—run by two sisters. This case study serves as a concrete example of success, combining family tradition, social commitment, and sustainable practices. In summary, the primary objective of this contribution is to demonstrate the compatibility of the social business model with the current and future socio-economic context. It highlights the model’s potential to contribute significantly to the resolution of social and environmental challenges while maintaining economic sustainability.
Divestment of foreign direct investment and domestic investment in developing countries agriculture
Authors: Badu-Prah Charlotte , Srofenyoh Francis Yao , Gidiglo Ferguson Korbla , Agyeiwaa-Afrane Akua , Agyei-Henaku Kofi Aaron Aboa-Offei , Djokoto Justice Gameli
Published: March 2024

Divestment of foreign direct investment has accompanied foreign direct investment. The literature on the interface of foreign direct investment and domestic investment in the agricultural sector is limited. None of these addressed the effect of agricultural foreign divestment on agricultural domestic investment. This paper filled this gap by assessing the direction and extent of the effect of agricultural foreign divestment on agricultural domestic investment in developing countries. The panel data of 50 countries, covering 1995 to 2020 and making up 619 observations, was fitted to fixed and random effects as well as generalised estimation equation estimators. We found agricultural foreign divestment crowded out agricultural domestic investment in developing countries. Economic managers in developing countries must work towards strong macroeconomic indicators, as these have collateral benefits for enhancing agricultural domestic investment.
The Socio-Economic Impact of Judicial Verdicts
Authors: Bhattacharya Arindam
Published: March 2024

The socio-economic impact of judicial verdicts is a critical area of inquiry within contemporary legal scholarship and governance discourse. This research paper delves into the intricate dynamics surrounding judicial decisions, aiming to unravel their implications for economic development, social cohesion, and democratic governance. Grounded in interdisciplinary dialogue and empirical analysis, the study offers insights that extend beyond academic inquiry to inform policy deliberations and practical interventions.
Against the backdrop of rapid globalization and evolving legal frameworks, understanding the complexities of judicial verdicts assumes paramount importance. This research endeavors to comprehensively explore the socio-economic dimensions underpinning judicial decisions, shedding light on disparities in access to justice, economic repercussions, and societal implications. Through a systematic examination of diverse legal systems and socio-cultural contexts, the study elucidates the multi-faceted nature of judicial impact on society.
The objectives of the research are structured to address critical gaps in understanding the socio-economic impact of judicial verdicts and to contribute meaningfully to scholarly discourse and policy deliberations in the field of law and governance. These objectives encompass examining socio-economic dimensions, identifying disparities in access to justice, assessing economic consequences, exploring social dynamics and public perceptions, and providing actionable policy recommendations and implications.
The significance of this research lies in its potential to generate knowledge, inform policy change, and foster inclusive governance practices that uphold principles of justice, equity, and human rights. By advancing interdisciplinary dialogue, empirical rigor, and policy relevance, the study serves as a catalyst for positive transformation within legal systems and societal institutions, contributing to the advancement of a more just, equitable, and democratic world.
While the research acknowledges certain limitations, including geographical and jurisdictional constraints, data availability and reliability, interdisciplinary complexity, and temporal constraints, it seeks to provide valuable insights and contributions to scholarly discourse and policy deliberations. Through rigorous analysis and engagement with international standards of scholarly inquiry, the research aims to foster informed decision-making and inclusive governance practices at the intersection of law, society, and governance.
Learning to Fiddle in a Community of Practice
Authors: Landry Rachelle , Stark Jody
Published: March 2024

This article explores some of the specific dynamics and processes experienced by Canadian old-time fiddlers as they learn to fiddle in a community of practice (CoP). Based on an analysis of interviews with several fiddlers at the Kenosee Lake Kitchen Party fiddling camp, we explore two elements of fiddling that the fiddlers identified as crucial to the development of expertise as an old-time fiddler: a danceable quality and personalizing a tune. Danceability allowed for historical continuity of the community’s practices, while making a tune your own provided a way to introduce new ideas and practices into the CoP, resulting in growth and change.
Preparation of high-performance large-area perovskite solar cells by atomic layer deposition of metal oxide buffer layer
Authors: Qu Zi-Han , Zhao Yang , Ma Fei , You Jing-Bi ,   Laboratory of Semiconductor Physics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China,   Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
Published: March 2024

Perovskite solar cells have been widely recognized as the most promising new-type photovoltaic device due to its power conversion efficiency rapidly increasing from 3.8% to over 26% in merely fifteen years. However, the high performances are achieved mainly on small area cells with an active area lower than 0.1 cm2. When enlarging the active area of perovskite solar cells, the efficiency falls dramatically. So, how to reduce the gap between performances of small area cells and large area cells gradually becomes a critical point in the path towards the commercialization of perovskite photovoltaic technology. Herein, a strategy of pre-growing thin layer of TiO2 on a rough FTO substrate by atomic layer deposition method before spin-coating SnO2 nanoparticles is proposed. Due to the inherent conformal film growth mode of atomic layer deposition, the FTO substrate can be completely covered by TiO2, thus preventing the direct contact between local protrusions of FTO and perovskite layer and impeding the current leakage phenomenon, which can be verified by the measurements from X-ray photoelectron spectroscopy, scanning electron microscopy, and atomic force microscopy, and further proved by the dark current measurement. By using this method, the repeatability and consistency of the small area cell fabrication technology on the same substrate are improved obviously. The improved electron transport process revealed by photoluminescence results and incident light management process revealed by external quantum efficiency results also brings about better solar cell performances. More importantly, highly efficient 0.5 cm2 large area perovskite solar cells are fabricated through optimization of TiO2 thickness. When growing 200 cycles TiO2 (~9 nm in thickness) by using atomic layer deposition technology, the champion large area perovskite solar cell possesses a power conversion efficiency as high as 24.8% (certified 24.65%). The device performances also show excellent repeatability between different fabrication batches. The perovskite solar cell with TiO2 buffer layer grown by the atomic layer deposition method can still retain over 95% of its initial efficiency after having been stored in a nitrogen atmosphere for 1500 h. The technique proposed in this paper can be helpful in manufacturing perovskite solar cell modules in the realistic photovoltaic market and can be extended to the large area fabrication of other perovskite optoelectronic devices such as light emitting diode, laser and detector.
Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease
Authors: Zhang Kejia , Eldin Patrick , Ciesla Jessica H. , Briant Laurence , Lentini Jenna M. , Ramos Jillian , Cobb Justin , Munger Joshua , Fu Dragony
Published: March 2024

Nonstructural protein 5 (Nsp5) is the main protease of SARS-CoV-2 that cleaves viral polyproteins into individual polypeptides necessary for viral replication. Here, we show that Nsp5 binds and cleaves human tRNA methyltransferase 1 (TRMT1), a host enzyme required for a prevalent post-transcriptional modification in tRNAs. Human cells infected with SARS-CoV-2 exhibit a decrease in TRMT1 protein levels and TRMT1-catalyzed tRNA modifications, consistent with TRMT1 cleavage and inactivation by Nsp5. Nsp5 cleaves TRMT1 at a specific position that matches the consensus sequence of SARS-CoV-2 polyprotein cleavage sites, and a single mutation within the sequence inhibits Nsp5-dependent proteolysis of TRMT1. The TRMT1 cleavage fragments exhibit altered RNA binding activity and are unable to rescue tRNA modification in TRMT1-deficient human cells. Compared to wildtype human cells, TRMT1-deficient human cells infected with SARS-CoV-2 exhibit reduced levels of intracellular viral RNA. These findings provide evidence that Nsp5-dependent cleavage of TRMT1 and perturbation of tRNA modification patterns contribute to the cellular pathogenesis of SARS-CoV-2 infection.
Conformational dynamics of a nicotinic receptor neurotransmitter binding site
Authors: Singh Mrityunjay , Indurthi Dinesh C. , Mittal Lovika , Auerbach Anthony , Asthana Shailendra
Published: March 2024

Agonists turn on receptors because they provide net favorable binding energy to active versus resting conformations of their target sites. We used simulations to explore conformational dynamics of the weak→strong binding transition at the
Torpedo
α–δ nicotinic acetylcholine receptor orthosteric site. Using 4 agonists, the alternative site conformations were identified in trajectories generated from a single starting structure by matching binding energies calculated
in silico
with those measured experimentally
in vitro
. The weak→strong transition starts with a rotation of the agonist about its cationic center (‘flip’), followed by a downward displacement of loop C that repositions αY190 (‘flop’), followed by formation of H-bonds between the ligand, a structural water and the δ subunit loop E backbone (‘fix’). The result is a compact, hydrophobic and stable pocket with higher affinity for agonists. The simulations reveal a transient intermediate state in the weak→strong transition.
Tgfbr1 regulates lateral plate mesoderm and endoderm reorganization during the trunk to tail transition
Authors: Lozovska Anastasiia , Nóvoa Ana , Kuo Ying-Yi , Jurberg Arnon D. , Martins Gabriel G. , Hadjantonakis Anna-Katerina , Mallo Moises
Published: March 2024

During the trunk to tail transition the mammalian embryo builds the outlets for the intestinal and urogenital tracts, lays down the primordia for the hindlimb and external genitalia, and switches from the epiblast/primitive streak to the tailbud as the driver of axial extension. Genetic and molecular data indicate that
Tgfbr1
is a key regulator of the trunk to tail transition.
Tgfbr1
has been shown to control the switch of the neuro mesodermal-competent cells from the epiblast to the chordo-neural hinge to generate the tail bud. We now show that Tgfbr1 signaling also controls the remodeling of the lateral plate mesoderm (LPM) and of the embryonic endoderm associated with the trunk to tail transition. In the absence of
Tgfbr1
the two LPM layers do not converge at the end of the trunk, extending instead as separate layers enclosing the celomic cavity until the caudal embryonic extremity, and failing to activate markers of primordia for the hindlimb and external genitalia. However, this extended LPM, does not exhibit the molecular signatures characteristic of this tissue in the trunk. The vascular remodeling involving the dorsal aorta and the umbilical artery leading to the connection between embryonic and extraembryonic circulation was also affected in the
Tgfbr1
mutant embryos. Similar alterations in the LPM and vascular system were also observed in
Isl1
null mutants, indicating that this factor acts in the regulatory cascade downstream of
Tgfbr1
in LPM-derived tissues. In addition, in the absence of
Tgfbr1
the embryonic endoderm fails to expand to form the endodermal cloaca and to extend posteriorly to generate the tail gut. We present evidence suggesting that the remodeling activity of
Tgfbr1
in the LPM and endoderm results from the control of the posterior primitive streak fate after its regression during the trunk to tail transition. Our data, together with previously reported observations, place
Tgfbr1
at the top of the regulatory processes controlling the trunk to tail transition.
Prolactin-mediates a lactation-induced suppression of arcuate kisspeptin neuronal activity necessary for lactational infertility in mice
Authors: Hackwell Eleni C.R. , Ladyman Sharon R. , Clarkson Jenny , McQuillan H. James , Boehm Ulrich , Herbison Allan E. , Brown Rosemary S.E. , Grattan David R.
Published: March 2024

The specific role that prolactin plays in lactational infertility, as distinct from other suckling or metabolic cues, remains unresolved. Here, deletion of the prolactin receptor (Prlr) from forebrain neurons or arcuate kisspeptin neurons resulted in failure to maintain normal lactation-induced suppression of estrous cycles. Kisspeptin immunoreactivity and pulsatile LH secretion were increased in these mice, even in the presence of ongoing suckling stimulation and lactation. GCaMP6 fibre photometry of arcuate kisspeptin neurons revealed that the normal episodic activity of these neurons is rapidly suppressed in pregnancy and this was maintained throughout early lactation. Deletion of Prlr from arcuate kisspeptin neurons resulted in early reactivation of episodic activity of kisspeptin neurons prior to a premature return of reproductive cycles in early lactation. These observations show dynamic variation in arcuate kisspeptin neuronal activity associated with the hormonal changes of pregnancy and lactation, and provide direct evidence that prolactin action on arcuate kisspeptin neurons is necessary for suppressing fertility during lactation.
Emerging role of oncogenic ß-catenin in exosome biogenesis as a driver of immune escape in hepatocellular carcinoma
Authors: Dantzer Camille , Vaché Justine , Brunel Aude , Mahouche Isabelle , Raymond Anne-Aurélie , Dupuy Jean-William , Petrel Melina , Bioulac-Sage Paulette , Perrais David , Dugot-Senant Nathalie , Verdier Mireille , Bessette Barbara , Billottet Clotilde , Moreau Violaine
Published: March 2024

Immune checkpoint inhibitors have produced encouraging results in cancer patients. However, the majority of ß-catenin mutated tumors have been described as lacking immune infiltrates and resistant to immunotherapy. The mechanisms by which the oncogenic ß-catenin affects immune surveillance remain unclear. Herein, we highlighted the involvement of ß-catenin in the regulation of the exosomal pathway and in the immune/cancer cell communication in hepatocellular carcinoma (HCC). We showed that mutated ß-catenin represses
SDC4
and
RAB27A
expression, two main actors of exosome biogenesis, in both liver cancer cell lines and HCC patient samples. Using nanoparticle tracking analysis and live-cell imaging, we further demonstrated that activated ß-catenin represses exosome release. Then, we demonstrated in 3D spheroid models that activation of β-catenin promotes a decrease of immune cell infiltration through a default in exosome secretion. Taken together, our results provide the first evidence that oncogenic ß-catenin plays a key role in exosome biogenesis. Our study gives new insight into the impact of ß-catenin mutations on tumor microenvironment remodeling, which could lead to the development of new strategies to enhance immunotherapy response.
Tead1 reciprocally regulates adult β-cell proliferation and function to maintain glucose homeostasis
Authors: Lee Jeongkyung , Liu Ruya , Kim Byung S. , Zhang Yiqun , Li Feng , Jagannathan Rajaganapti , Yang Ping , Negi Vinny , Danvers Joseph , Perez-Garcia Eliana Melissa , Saha Pradip K. , Sabek Omaima , Creighton Chad J. , Coarfa Cristian , Huising Mark O. , Shih Hung-Ping , Bottino Rita , Ma Ke , Moulik Mousumi , Yechoor Vijay K.
Published: March 2024

Proliferative quiescence in β-cells is required to maintain functional competence. While this presents a significant hurdle in regenerative therapy for diabetes, the molecular underpinnings of this reciprocal relationship remain unclear. Here, we demonstrate that TEAD1, the transcription effector of the mammalian-Hippo pathway, drives developmental stage-specific β-cell proliferative capacity in conjunction with its functional maturation. TEAD1 promotes adult β-cell mature identity by direct transcriptional control of a network of critical β-cell transcription factors, including,
Pdx1, Nkx6.1, and MafA,
while its regulation of
Cdkn2a
maintains proliferative quiescence. Consequently, mice with either constitutive or inducible genetic deletion of
TEAD1
in β-cells developed overt diabetes due to a severe loss of secretory function despite induction of proliferation. Furthermore, we show that TEAD1 has a similar regulatory role in human β-cells. Consistent with this function in β-cells, variants in
TEAD1
have been associated with c-HOMA-B in American Indians. We propose that TEAD1 is an essential intrinsic molecular switch coordinating adult β-cell proliferative quiescence with mature identity and its differential modulation may be necessary to overcome the challenge of inducing proliferation with functional competence in human beta cells.
Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer
Authors: Yue Fei , Ku Amy T. , Stevens Payton D. , Michalski Megan N. , Jiang Weiyu , Tu Jianghua , Shi Zhongcheng , Dou Yongchao , Wang Yi , Feng Xin-Hua , Hostetter Galen , Wu Xiangwei , Huang Shixia , Shroyer Noah F. , Zhang Bing , Williams Bart O. , Liu Qingyun , Lin Xia , Li Yi
Published: March 2024

ZNRF3 and RNF43 are closely related transmembrane E3 ubiquitin ligases with significant roles in development and cancer. Conventionally, their biological functions have been associated with regulating WNT signaling receptor ubiquitination and degradation. However, our proteogenomic studies have revealed EGFR as the most negatively correlated protein with
ZNRF3/RNF43
mRNA levels in multiple human cancers. Through biochemical investigations, we demonstrate that ZNRF3/RNF43 interact with EGFR via their extracellular domains, leading to EGFR ubiquitination and subsequent degradation facilitated by the E3 ligase RING domain. Overexpression of
ZNRF3
reduces EGFR levels and suppresses cancer cell growth
in vitro
and
in vivo
, whereas knockout of
ZNRF3
/
RNF43
stimulates cell growth and tumorigenesis through upregulated EGFR signaling. Together, these data highlight ZNRF3 and RNF43 as novel E3 ubiquitin ligases of EGFR and establish the inactivation of ZNRF3/RNF43 as a driver of increased EGFR signaling, ultimately promoting cancer progression. This discovery establishes a connection between two fundamental signaling pathways, EGFR and WNT, at the level of cytoplasmic membrane receptor, uncovering a novel mechanism underlying the frequent co-activation of EGFR and WNT signaling in development and cancer.
Bidirectional fear modulation by discrete anterior insular circuits in mice
Authors: Park Sanggeon , Huh Yeowool , Kim Jeansok J. , Cho Jeiwon
Published: March 2024

The brain’s ability to appraise threats and execute appropriate defensive responses is essential for survival in a dynamic environment. Humans studies have implicated the anterior insular cortex (aIC) in subjective fear regulation and its abnormal activity in fear/anxiety disorders. However, the complex aIC connectivity patterns involved in regulating fear remain under investigated. To address this, we recorded single units in the aIC of freely moving mice that had previously undergone auditory fear conditioning, assessed the effect of optogenetically activating specific aIC output structures in fear, and examined the organization of aIC neurons projecting to the specific structures with retrograde tracing. Single-unit recordings revealed that a balanced number of aIC pyramidal neurons’ activity either positively or negatively correlated with a conditioned tone-induced freezing (fear) response. Optogenetic manipulations of aIC pyramidal neuronal activity during conditioned tone presentation altered the expression of conditioned freezing. Neural tracing showed that non-overlapping populations of aIC neurons project to the amygdala or the medial thalamus, and the pathway bidirectionally modulated conditioned fear. Specifically, optogenetic stimulation of the aIC-amygdala pathway increased conditioned freezing, while optogenetic stimulation of the aIC-medial thalamus pathway decreased it. Our findings suggest that the balance of positive and negative neuronal activity in the aIC and the distinct efferent circuits interact collectively to modulate fear behavior.