bluuebunny/crossref_metadata_2025 huggingface dataset:
The Association of Metabolic Syndrome and Psoriasis: A Systematic Review and Meta-Analysis of Observational Study
Authors: Choudhary Saumya , Pradhan Dibyabhaba , Pandey Anamika , Khan Mohd. Kamran , Lall Rohit , Ramesh V. , Puri Poonam , Jain Arun K. , Thomas George
Published: October 2019

Background:

Metabolic syndrome worsens complications in psoriasis patients by predisposing them to cardiovascular diseases. Psoriasis has been widely associated with metabolic syndrome; however, it has still not been proven owing to a limited number of studies and some of those reporting conflicting results.

Objective:

Psoriasis has reportedly been associated with metabolic syndrome; however, it has yet not been established beyond doubt owing to conflicting literature. The present meta-analysis of observational studies aims to evaluate the prevalence of metabolic syndrome in psoriasis patients and establish an inferring point that psoriasis patients are certainly susceptible to metabolic syndrome. The study will benefit clinicians to assess and monitor psoriasis patients for several associated comorbid conditions and in its treatment.

Methods:

A systematic web search for ‘Psoriasis’, ‘Metabolic Syndrome’, ‘Hypertension’, ‘Plasma Glucose’, ‘Dyslipidaemia’, ‘Waist Circumference’ was performed, collecting all original observational studies on humans up to April 30, 2018. Depending on the inclusion and exclusion criteria, articles were screened for eligibility. Due to the presence of significant heterogeneity, the Odds Ratio (OR) was calculated using a random-effect model with Der-Simonian and Laird method. The statistical heterogeneity was determined using I2 statistics. Comprehensive Meta-Analysis Software, Version 3 was used to perform all the analysis.

Results:

Sixty-three studies encompassing 15,939 psoriasis patients and 103,984 controls were included in this meta-analysis. Among them, 30.29 % of psoriasis patients were reported with metabolic syndrome in comparison to 21.70 % of subjects in the control group. The present study clearly indicates an increased prevalence of metabolic syndrome among psoriasis patients (OR: 2.077 [95% CI, 1.84 - 2.34]).

Conclusions:

The findings support the fact that psoriasis patients have a higher incidence of metabolic syndrome. Our study also recommends that psoriasis patients should be regularly monitored for metabolic syndrome complications and its associated risk factors such as hypertension, raised triglyceride, lowered HDL Cholesterol, increased fasting plasma glucose, and waist circumference.
Identification of Termites’s Hindgut Bacterial Symbionts (Coptotermes curvignathus Holmgren) and the Feasibility in Rice Straw Decomposting
Authors: Sembiring Marheni , Gusriani Yunda
Published: October 2019

Cellulotic bacteria can be used as breakers of cellulose bonds in rice straw, one of which is cellulotic symbiont bacteria found in the hindgut part of termite Coptotermes curvignathus Holmgren. The study aimed to characterize and identify bacterial isolates from the back intestine of C. curvignathus termites and test the ability of bacterial isolates to decomposition rice straw. The results of isolation on worker caste termites found one bacterial species that was successfully cultured in Carboxylmethil Cellulose (CMC) media. Biochemical test results for isolates, showed that, bacteria found in rod form (rod shape), aerobic, gram negative, motile and produced catalase enzyme. Sequencing of 16S rRNA genes in bacterial isolates showed similarities with Bacillus cereus. A dose of 10 ml symbiont starter, 50% in concentration, applied to 2 kg rice straw can shorten the decomposition time from 12 weeks to 4 weeks, reducing the required decomposition time which is about 75% of the normal time.
Selection and Inheritance of Tomato Resistance against Ralstonia solanacearum
Authors: Maulida Isna , Murti Rudi Hari , Arwiyanto Triwidodo
Published: October 2019

Ralstonia solanacearum is a plant pathogen causes wilting which is a major obstacle in the cultivation of tomato plants. In plant breeding, knowledge of the source of resistance genes and inheritance patterns is important in the development of bacterial wilt resistant varieties. This study aimed to obtain bacterial wilt resistant lines and to find out the inheritance pattern of tomato resistance to bacterial wilt. Selection of resistant plant involved the selected breeding lines from irradiation and crossing collections of the Genetic Laboratory, Faculty of Agriculture, Universitas Gadjah Mada. Introduced lines of H-7996 and F1 Permata and Timoti were used as a control. H-7996 as resistant parents and GM2 as susceptible parents, and their offspring include F1 GM2 x H-7996, F1 reciprocal, F2, Back Cross 1 (F1 x GM2), and Back Cross 2 (F1 x H-7996) used in testing inheritance patterns. Inoculation was carried out 1 week after planting by pouring 100 ml of water suspension of R. solanacarum (108  cfu/ml) on the roots. Completely Randomized Design (CRD) was used in this experiment. The scoring observation was carried out every week for one month. This study showed that Permata as a control was the most resistant, while Timoti and H-7996 were medium resistant. The CLN, G6, G8, and G7 lines were susceptible medium, yet only G8 and G7 with the smallest percentage of disease intensity and not significantly different than Timoti. The resistance gene to bacterial wilt on H-7996 was controlled by genes in the cell nucleus with additive-dominant gene action. Resistance to bacteria has a moderate level of heritability.
Detection and Identification of Banana-associated Phytoplasma Using Nested-PCR Method
Authors: Sibarani Saurma Mona Astrid , Joko Tri , Subandiyah Siti
Published: October 2019

Phytoplasma is known to be associated with plant diseases in about 300 plant species from various families. Information on the presence of phytoplasma in bananas as one of the pathogens that can cause disease in bananas in Indonesia has never been reported. This research was conducted with the aim to detect the presence of banana phytoplasma by the nested-PCR method and to identify phytoplasma obtained based on the sequence analysis of the 16S rRNA gene. Standard PCR was carried out using P1/P7 primary pairs, followed by nested-PCR using a pair of R16F2n/R16R2m23SR primers separately that could amplify the target 16S rRNA genes in a row at 1600 bp. BLAST analysis shows that the results of phylogenetic analysis of banana phytoplasmic nucleotide cv. manggala from Tasikmalaya and cv. Raja nangka from Banjar has a genetic relationship that is closer to lethal wilt oil palm Phytoplasma (Candidatus Phytoplasma asteris). This phytoplasma belongs to the 16SrI-B group (aster yellows).
Institutional Factors Influencing Acquisition of Vocational Skills by Trainees in Public Vocational Training Centers in Kakamega County-Kenya
Authors: Maingi Josephine M. , Obaki Samuel O. , Sang Anthony
Published: October 2019

Vocational Training Centers (VTCs) are anchored in the Technical Vocational Education and Training ACT (2013), which emphases on imparting vocational and technical skills in trainees. The purpose of this study was to determine the institutional factors influencing acquisition of vocational skills by trainees in public vocational training centres in Kakamega County. The study adopted a descriptive survey. The target population of the study was 1740 comprising of 60 county polytechnic, 60 county polytechnic principals, 480 instructors and 1200 second year finalist trainees. A sample size of 282 was picked consisting of 18 county polytechnic principals, 144 instructors and 120 second year finalist trainees as the respondents. Stratified random, purposive and simple random sampling was employed. Questionnaires were used to collect data from county polytechnic principals, instructors and trainees. Data were analyzed using both descriptive and inferential statistics. The study established that instructors were inadequate and the existing ones lacked in-service and industrial updates, financial resources were also inadequate to cater for training facilities and payment of more Board of Management instructors, tools and equipment were inadequate and not up to date and this forced instructors to use teacher-centered methods of instructing.
UNDERWRITING PERFORMANCE SHOCKS IN THE NON-LIFE NIGERIAN INSURANCE INDUSTRY AND MACROECONOMIC RISKS: A VECTOR AUTO REGRESSIVE APPROACH
Authors: Onafalujo Akinwunmi Kunle
Published: October 2019

Insurance company’s performance can be stymied by internal and external risks. Industry reports show 23 companies out of the 55 operating companies (about 42%) in Nigeria recorded net operating losses in 2015. Macroeconomic risks are external and may be quite significant in providing an (un)favourable environment for performance of the industry particularly in a developing economy like Nigeria. Reflecting on the contribution of insurance to the Nigerian economy which shows an abysmally low penetration, averaging below one percent of GDP when compared to African peers such as South Africa at 13% and Kenya above two percent; it is of essence to investigate how these risks affect its performance which by implication could adversely affect insurance penetration. Dynamic least square regression technique was employed to study the dynamics of macroeconomic risks (GDP, inflation rate, and interest rate) on underwriting performance over the period 1981-2015. Weighed against theoretical underpinnings and other studies particularly in western economies, the study has evidence that interest and inflation rate shock adversely underwriting performance. Also, real GDP does not have positive shock on premium growth and loss ratio.  Monetary policy should address inflation, and interest rates if the underwriting performance shocks in the non-life sector are to be mitigated in Nigeria. In the long term, government should focus on how to improve income per capita and reduce income inequality and dependency ratio so as to connect insurance consumption to real GDP growth.
DOMESTIC AND FOREIGN FINANCING SOURCES IMPACT ON THE ECONOMIC DEVELOPMENT OF THE REPUBLIC OF SERBIA
Authors: Radisavljević Goran , Milovanović Goran , Bjeletić Saša
Published: October 2019

The aim of the paper is to analyze the effects of selected sources of financing on the economic development of the Republic of Serbia in the period from 2012 to 2016 on the basis of systematized statistical data. First, the theoretical framework of domestic and foreign sources of financing and the impacts of these sources on economic development are presented from the perspective of contemporary theory. This is followed by the analysis of the impact of domestic sources of financing (domestic savings, state and private sector) on the economic development of the Republic of Serbia. Finally, the paper examines the relevance of foreign direct investment (FDI) for encouraging restructuring, competitiveness, growth, and development of the economy of the Republic of Serbia.
On Ultrasonic Control of the Thickness of Plasma Surfacing of Copper-Nickel Alloy on a Steel Cylindrical Surface
Authors: Uglov A. L. , Khlybov A. A. , Kolesnikov M. V. , Bystrukova T. V. , Bychkov A. L.
Published: October 2019

Известно, что для улучшения эксплуатационных характеристик металлических изделий широко применяются наплавки, в частности плазменные. В работе исследовалась плазменная наплавка из медно-никелевого сплава, нанесенная на стальную цилиндрическую поверхность. К наплавкам предъявляются повышенные требования: стабильность толщины покрытия, отсутствие макроскопических дефектов в виде трещин и непроваров как в толще наплавки, так и в зоне сплавления.Учитывая, что акустические свойства медно-никелевой наплавки и основного металла близки по своим характеристикам, обеспечить контроль качества наплавки существующими методиками (на базе акустических методов) достаточно сложно, особенно в условиях массового производства. В связи с этим возникает необходимость дальнейшего развития существующих методов и методик контроля толщины наплавок, акустические свойства которых близки к свойствам основного металла.Для решения данной проблемы были проведены исследования, которые показали, что можно использовать наклонный преобразователь поперечных волн с углом ввода, обеспечивающим контроль заданной толщины покрытия  с погрешностью 0,02 мм. Экспериментальные данные, полученные акустическим методом, подтверждены результатами химического травления. Также по результатам этих исследований предложен автоматический контроль толщины покрытия с выводом результатов контроля в базу данных и на экран монитора.
Evaluación de la educación superior en Brasil y sus mecanismos de accountability: el SINAES en foco
Authors: Do Nascimiento de Paula Alisson Silder
Published: October 2019

Este estudio busca analizar los mecanismos que conforman el SINAES (Sistema Nacional de Avaliação da Educação Superior), su vinculación con la noción de accountability y la definición de calidad adoptada por este sistema de evaluación. Se trata de una investigación cualitativa. El tipo de estudio corresponde al bibliográfico y documental. La técnica de análisis corresponde al análisis de contenido. De hecho, la evaluación de la educación superior en la historia reciente de Brasil ha experimentado y experimenta varias transformaciones, con avances y retrocesos desde el punto de vista operativo. El énfasis puesto en la ENADE y los marcos regulatorios que condicionan el modus operandi de las instituciones de educación superior en Brasil se expresan como un modelo de accountability.
“Ser femenina, ser delicada, ser madre”. Representaciones sociales de género del profesorado: un estudio cualitativo
Authors: Ramírez-Pereira Miriliana
Published: October 2019

Las Representaciones Sociales de Género, están relacionadas con los estereotipos y roles que interfieren en el desarrollo de las personas. El objetivo de esta investigación es comprender las representaciones sociales de género en profesores y profesoras de enseñanza primaria, en Santiago de Chile. La investigación es de tipo cualitativa desde un paradigma post positivista, se realizaron entrevistas en profundidad como método de recolección de datos a profesores, siguiendo la técnica de bola de nieve, las cuales fueron sometidas a análisis de contenidos. Dentro de los principales resultados destaca la reproducción de representaciones sociales diferenciado según sexo biológico y por otro lado el esfuerzo de profesores por promover igualdad de género al interior de las aulas.
The Poetics Of A Multiphonic Landscape
Authors: Torben Snekkestad
Published: October 2019

The project is an artistic research project focusing on the saxophone􏰁s ability to produce multiphonics (multiple sounds on an instrument considered monophonic). It is a personal artistic exploration into the process of unfolding the poetics of these complex sonics and a reflection over the process, methods and the creation of an album trilogy, consisting of acoustic solo music recorded during the research period.

The main question I have been asking myself during this project has been:

What happens if the raw musical material, in the creation of a set of solo saxophone works, is based on the multiphonics only and what this material in itself suggest – possibly independent of any stylistic affiliation?

 My main objective was to examine why the saxophone’s multiphonics have such a captivating effect on me. How could I possibly explore their intrinsic qualities and unfold the poetic potential in them? By the same token, my ambition was to find a suitable artistic context for this enamored relationship that so heavily has stirred the waves of my imagination.

In the reflection text on the project, I disclose how some unexpected paths during this pursuit revealed themselves. From sprouting interest toward underwater soundscapes, to the making of a hybrid instrument called reed-trumpet; and how my personal catalog of multiple sounds found its place, not in a public pdf-document or book release, but in a German wooden archive box.

I relay in what way I began to take on the intrinsic qualities of the multiphonics and the reason why an oscillation between artistic intention and action is so pivotal for an improviser. To make sure that the project had this focus at all time I sat up a dogma that contains a list of eight fundamental criteria that manifest the intentions and structure as well as sharpen the working methods.
Norma internacional de auditoría (NIA) 220: control de calidad para auditorías de información financiera histórica y el desempeño del auditor externo
Authors: Parrado Rincon Whiter Smith , Gutiérrez Ladino Edisson Leonardo , Rodríguez Ruiz Juan Carlos
Published: October 2019

En este artículo se aborda la Norma Internacional de Auditoría (NIA) 220 que hace relación al Control de Calidad de la Auditoría de Estados Financieros, mediante la cual se establecen las responsabilidades específicas del personal de la firma, respecto de procedimientos de control de calidad para auditorías de información financiera histórica. Su objetivo fue identificar el conocimiento que tienen los Contadores Públicos de la ciudad de Villavicencio, de la Norma Internacional de Auditoría (NIA) 220 que hace relación al Control de Calidad de la Auditoría de Estados Financieros. El método utilizado fue el cuantitativo, mediante el cual se analizó la información obtenida de Contadores Públicos de la Universidad Cooperativa de Colombia, Sede Villavicencio, obteniendo como resultados que existe desconocimiento por parte de los Contadores Públicos que ejercen como Auditores Externos especialmente en las responsabilidades que tiene el Socio de Trabajo dentro de su equipo, por lo que se concluye que este desconocimiento de la norma le impide asumir la responsabilidad de la calidad global de los trabajos que realiza su empresa.
Evidence of ferroelectric behaviour in CaCu3Ti4O12 thin films deposited by RF-sputtering
Authors: Foschini Cesar , Hangai Bruno , Ortega Paulo , Longo Elson , Cilense Mário , Simões Alexandre
Published: October 2019

The origin of abnormal ferroelectric and unusual piezoelectricity in the
polycrystalline CaCu3Ti4O12 (CCTO) thin films deposited by RF-sputtering on
Pt/Ti/SiO2/Si (100) substrates was explored. The CCTO thin films, deposited
at room temperature followed by annealing at 600?C for 2 h in a
conventional furnace, have a cubic structure with lattice parameter a =
7.379 ? 0.001 ? and without any secondary phases. No polarization loss up to
1010 switching cycles, with a switched polarization ?P of 30 ?C/cm2 measured
at 400 kV/cm was evidenced. The piezoelectric coefficient investigated by
piezoresponse force microscopy (PFM) was approximately 9.0 pm/V. This may be
the very first example of exploring the origin of ferroelectric behaviour
for a material that possesses space charge polarization with highly
resistive grain boundaries in the polycrystalline state.
Antitumor effect of mifepristone on human endometrial stromal cell line
Authors: Lukovic Jovan , Milosavljevic Zoran , Zecevic-Lukovic Tanja , Mitrovic Marina , Andjelkovic Marija , Zelen Ivanka , Stanojevic-Pirkovic Marijana , Nikolic Ivana
Published: October 2019

Background/Aim. The main cause for development of endometrial hyperplasia is unopposed effect of estrogen on endometrial cells. The aim of our study was to investigate and compare cytotoxic and apoptotic effects of mifepristone on human endometrial stromal cell line for the first time. Both percentage of cytotoxic and apoptotic cells were determined after 24 h treatment with different doses of mifepristone. Methods. The percentage of cytotoxic cell was evaluated by viability assay while the percentage of apoptotic cells was determined using flow cytometry. Determination of apoptotic effects was confirmed using immunofluorescence method determining expression and localization of active Bax and Bcl-2 proteins. Results. Our results indicated that mifepristone induced cytotoxic and apoptotic effect on human endometrial stromal cell line (ThESC) through changes in expression level of Bcl-2 and active Bax proteins. Conclusion. Cytotoxic and pro-apoptotic effects of mifepristone on human endometrial stromal cell line in vitro was investigated in this study for the first time. It is crucial to point out that mifepristone expressed both cytotoxic and pro-apoptotic effect on ThESC cell line. Our results may contribute to determination of localization and expression level of the crucial proteins involved in apoptosis in ThESC cell line after the treatment with the lowest cytotoxic doses of mifepristone.
A case report of an unusual kidney tumor: Mucinous tubular and spindle cell carcinoma
Authors: Lakic Tanja , Ilic Aleksandra , Zivojinov Mirjana , Ilic-Sabo Jelena , Jeremic Dimitrije , Grbic Dragan
Published: October 2019

Introduction. Mucinous tubular and spindle cell carcinoma of the kidney (MTSCC) is a rare and recently described subtype of renal cell carcinoma (RCC). As its name indicates, the tumor is composed of three morphological structures: tubules consisted of cuboidal cells, spindle cells, and extracellular mucus. Case report. A 59-year-old female patient was admitted to the Emergency Center of the Clinical Center of Vojvodina due to injuries sustained in a traffic accident. After diagnostic procedures, computer tomography (CT) revealed a large asymptomatic cyst of the upper pole of the left kidney as an incidental finding. Four months later, after recovering from traumatic injuries, a control CT confirmed a well-circumscribed tumor, 90 mm in diameter, confined to a kidney, and a radical nephrectomy was performed. Histopathological evaluation showed that the necrotic tumor mass consisted of tubules made of cuboidal cells and cords made of spindle cells separated by pale mucinous material in some areas, while other tumor parts were of dense cellularity without mucin. No atypia was found. Conclusion. MTSCC is a variant of papillary RCC, thus, it is usually mistaken with papillary RCC with sarcomatoid differentiation. Because of the same immunoprofile as papillary RCC, histomorphology is imposed as the gold standard for making the diagnosis. MTSCC is a tumor with a generally favorable prognosis, and complete surgical excision appears to be adequate treatment, but single cases with metastatic disease have been reported. In this case, there were no signs of the dis-ease one year after surgery.
PENGEMBANGAN BAHAN AJAR IPS BERBENTUK HANDOUT BERMUATAN KEARIFAN LOKAL BALI UNTUK MENINGKATKAN NILAI PEDULI SOSIAL DAN ETIKA LINGKUNGAN
Authors: Ramastuti Ni Wayan , Atmaja Nengah Bawa , Lasmawan I Wayan
Published: October 2019

Tujuan penelitian ini untuk mengetahui (1) mengembangkan bahan ajar IPS bermuatan kearifan lokal bali dalam pembelajaran IPS, (2) mengkaji efektivitas penggunaan bahan ajar IPS bermuatan kearifan lokal Bali terhadap nilai peduli sosial dan etika lingkungan siswa SMP Negeri 1 Marga. Penelitian ini menggunakan metode teknik analisis data yang sesuai dengan sifat dan jenis data. Untuk data yang bersifat kualitatif digunakan teknik analisa deskriptif secara logis. Populasi penelitian ini adalah kelas VII G. Pengumpulan data menggunakan observasi. Hasil penelitian menunjukkan bahwa (1) bahan ajar yang berupa handout dengan persetujuan kedua validator sehingga handout tersebut dinyatakan valid atau layak digunakan di lapangan dengan revisi. (2) Efektivitas penggunaan bahan ajar IPS bermuatan kearifan lokal Bali terhadap nilai peduli sosial siswa SMP Negeri 1 Marga sangat efektif setelah diberikan perlakuan (treatment) dengan bukti sikap siswa terkait nilai peduli sosial dan etika lingkungan mengalami peningkatan sebesar 33,49% dari rata-rata sebelum diberikan perlakuan dengan nilai yaitu 46,28 dan setelah diberikan perlakuan nilai tersebut menjadi naik hingga mencapai angka rata-rata 79,77. Kata Kunci: Handout, Kearifan Lokal, IPS
Pengaruh Model Make A Match Berbantuan Peta Pikiran Terhadap Sikap Sosial dan Kompetensi Pengetahuan IPS
Authors: Nia Wijayanti Ni Wayan , Gading I Ketut , Parmiti Desak Putu
Published: October 2019

Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran make a match berbantuan peta pikiran terhadap sikap sosial dan kompetensi pengetahuan IPS siswa kelas IV Sekolah Dasar. Penelitian ini merupakan penelitian eksperimen semu dengan rancangan non-equivalent pretest-posttest control group design. Populasi penelitian ini adalah seluruh siswa kelas IV SD di Gugus III Kecamatan Marga tahun pelajaran 2018/2019. Sampel penelitian diambil menggunakan teknik undian dengan memilih 2 kelas dari 8 kelas anggota populasi. Sampel penelitian ini berjumlah 60 orang siswa yaitu 34 orang siswa kelas IV SD Negeri 2 Kuwum sebagai kelompok eksperimen dan 26 orang siswa kelas IV SD Negeri 3 Marga sebagai kelompok kontrol. Instrumen pengumpulan data dalam penelitian ini adalah kuesioner sikap sosial dan tes kompetensi pengetahuan IPS. Data yang telah dikumpulkan dianalisis dengan uji MANOVA. Hasil uji hipotesis I menunjukkan bahwa F= 747,557; sig<0,05. Hasil uji hipotesis II menunjukkan bahwa F= 101,540;sig<0,05. Hasil uji hipotesis III menunjukkan bahwa F= 72,168;sig<0,05. Berdasarkan temuan di atas dapat disimpulkan bahwa model pembelajaran make a match berbantuan peta pikiran berpengaruh terhadap sikap sosial dan kompetensi pengetahuan IPS siswa kelas IV SD di Gugus III Kecamatan Marga tahun pelajaran 2018/2019.Kata kunci: make a match, kompetensi pengetahuan IPS, peta pikiran, sikap sosial
Pemanfaatan Koperasi Sekolah Sebagai Sumber Belajar IPS Pada SMP Negeri 3 Banjar
Authors: Laviani Kadek Devi , Haris Iyus Ahkmad , Tungga Admaja Ananta Wikrama
Published: October 2019

Penelitian ini dilaksanakan di SMP Negeri 3 Banjar dengan tujuan (1). menjelaskan nilai-nilai yang ditanamkan dalam koperasi sekolah sebagai sumber belajar IPS, (2). pemanfaatan koperasi sekolah dapat meningkatkan kreativitas siswa di SMP Negeri 3 Banjar, dan (3). koperasi sekolah bermanfaat sebagai sumber belajar IPS dalam pengembangan materi pembelajaran IPS kelas VII di SMP Negeri 3 Banjar. Penelitian ini merupakan penelitian pengembangan (Research and Development) dengan tahapan sebagai berikut Tahap Define, Design dan Develop. Hasil penelitian menunjukkan bahwa 1). Nilai-nilai perkoperasian sudah ditanamkan siswa di SMP Negeri 3 Banjar dalam proses pembelajaran IPS. 2) Hasil validasi draf produk menunjukkan bahwa bahan ajar yang disusun memiliki kelayakan dari ahli materi dan praktisi guru dengan persentase keseluruhan sebesar 77,27%. Berdasarkan hasil tersebut, pengembangan handout materi yang memanfaatkan koperasi sekolah sebagai sumber materi ajar IPS layak digunakan, dan 3). Hasil pengamatan dari keseluruhan indikator menunjukkan kreativitas siswa belum mencapai kriteria keberhasilan yang diinginkan dalam siklus 1. Hasil persentase yang diperoleh dari pengamatan kreativitas siswa masih kurang dari 76% yaitu 74,95%, sehingga belum mencapai kriteria keberhasilan yang diinginkan. Berdasarkan hasil observasi keaktifan siswa pada siklus II, menunjukkan bahwa pada setiap indikator kreativitas siswa pada setiap pertemuan sudah mengalami peningkatan dalam indicator keberhasilan yang telah ditetapkan sebesar ≥76%. Hasil persentase untuk keseluruhan indikator kreativitas menunjukkan rata-rata kreativitas siswa pada siklus II sebesar 87,81%.Kata kunci: Koperasi Sekolah, Sumber Belajardan Kreativitas
Structural condition of synovial medium of joint in patients with III stage coxarthrosis
Authors: Menshchikova Tatyana I. , Matveeva Elena L. , Lyneva Svetlana N. , Menshchikov Ilya N. , Spirkina Elena S.
Published: October 2019

Aim. To study peculiarities of synovial medium of a joint in patients with III stage coxarthrosis (CA) using methods of ultrasound and biochemical examination.
Materials and Methods. Ultrasound examination (US) of hip joints (n=18) and biochemical examination of synovial fluid (n=12) were conducted in patients with posttraumatic III stage CA. Echographic examination was carried out using diagnostic devices Voluson 730 PRO (Austria) and Hitachi (Japan) equipped with transductor with 7.5 MHz frequency. Total protein was measured in alkaline medium with copper sulfate. Protein fractions of synovial fluid were separated using a method of separation of a mixture of proteins to fractions or to individual proteins. The activity of catalase enzyme was determined by speed of degradation of hydrogen peroxide and of liberation of cell from its excess. Processes of peroxide oxidation of lipids (POL) were assessed by measurement of the content of the primary (diene conjugates, DC) and secondary (malondialdehyde, MDA) products of POL. Products of lipoperoxidation and of oxidative modification of proteins were presented as an estimated coefficient of sum and ratios. Lipid spectrum (cholesterol, triglycerides) was measu-red using a colorimetric method.
Results. There were revealed structural disorders in the synovial medium of the joint. US data showed thickening of synovial and fibrous membranes of the joint capsule by 60 and 40% of the age-related norm, separation of fibers of the fibrous membrane of the joint. Biochemical examination of synovial fluid revealed reduction in the activity of enzymes of antioxidant system and accumulation of peroxidation products which evidences development of a local oxidative stress in the joint medium. In development of destructive processes in the region of joints affected by arthrosis, the activity of free radical processes considerably increases which leads to decompensation of antioxidant mechanisms with development of imbalance in the anti-oxidant protection system.
Conclusion. In clinical practice, diagnosis of degenerative-dystrophic processes in the joint, along with X-ray data, should also include the results of biochemical and ultrasound methods of examination.
Expression of p63 protein in pulmonary adenocarcinomas as factor of poor prognosis
Authors: Byakhova Maria M. , Glazkov Alexey A. , Vinogradov Igor Yu. , Frank George A.
Published: October 2019

Aim. To study the spectrum of cellular molecular-biological markers and identify those of them that can be used as prognostic factors for the clinical course of pulmonary adenocarcinoma.
Material and Methods. In the given work archive material of 129 patients with confirmed diagnosis of pulmonary adenocarcinoma was used. In the work, histological, immunohistochemical, molecular-genetic and statistical methods were used.
Results. In 29 cases (47.5%) of pulmonary adenocarcinoma, focal cytoplasmic and/or nuclear expression of p63 protein was observed in different proportions of cells. With expression of p63 in tumor cells, relapse-free survival was on average 25.7±5.1 months, while in patients with no expression of р63 it was 26.1±2.8 months. This parameter did not influence the overall survival of patients which was on average 33.6±2.7 months.
Conclusion. A weak tendency to reduction of relapse-free survival of patients with p63-positive pulmonary carcinoma of lungs was revealed. Identification of p63 in pulmonary adenocarcinoma may be regarded as a factor of unfavorable prognosis and of risk of faster tumor progression, which requires further study to increase the statistical value of research.
Physiological ‘cost’ of activity of individuals with different effectiveness in dynamics of endosurgical training
Authors: Klimenko Aleksey V. , Pertsov Sergey S. , Yakovenko Igor. Yu. , Levkin Eugene I. , Samratov Timur U. , Gubenko Marina S.
Published: October 2019

Aim. The work was designed to study the physiological ‘cost’ of purposeful behavior on the model of endosurgical training.
Materials and Methods. The research was implemented on 87 men of 18-24 years of age. The volunteers per formed a number of exercises 30 minutes each according to the Basic Endosurgical Simulation Training and Attestation System (BESTA system) on a T5 Large RM box-trainer within 10 consecutive days. The total time and the number of mistakes were recorded. During the training sessions an electromyogram was recorded on a BIOPAC MP 36 device. ECG was recorded and processed using a Varicard 2.51 device before and after the training sessions. ECG was analyzed by evaluation of the average differences of spectral analysis of heart rate variability before and after training.
Results. It was shown that high-performance individuals were characterized by less energy spent on motor work in purposeful activity. Irrespective of the effectiveness of training, the purposeful behavior in conditions of psychoemotional stress was characterized by depletion of functional reserves of an organism. Low-performance subjects demonstrated a more evident weakening of parasympathetic (start of observations) and of sympathetic influences (end of observations) on the functional activity of the heart.
Conclusion. Specific features of physiological ‘cost’ of purposeful behavior in individuals with different effectiveness of the activity were revealed on the model of endosurgical training. Better results in the dynamics of purposeful activity were achieved on this model at a higher physiological ‘cost’.
Morphological status of students with different level of motor activity
Authors: Mikhailova Svetlana V. , Deryugina Anna V. , Syomova Svetlana G.
Published: October 2019

A study of the effect of motor activity on the health condition of students that generalizes peculiarities of the morphological status and of physical development on the whole, permits to identify mechanisms controlling health factors.
Aim. Determination of the peculiarities of the dynamics of morphological status of students with different levels of motor activity in the period of study at aninstitution of higher education (IHE).
Materials and Methods. A prospective study of physical health of 630 students of 17-22 years of age in the period from 2010 to 2018. In students, the body length, body mass, chest circumference and other parameters were measured and the somatotype was determined every year in the period of study at anIHE (5 years).
Results. It was found that in the period of study at anIHE, growth processes continued only in 51.9% of examined boys and gradually terminated at 21-22 years of age, and in 36.9 % of girls with termination at 21-22 years. In most students increment of the body mass and chest circumference was recorded, there were also found boys and girls with these parameters remaining unchanged during period of study at anIHE, and in some cases their decline was found. The increment of the body mass and chest circumference was demonstrated to slow down with termination of growth processes, but did not stop altogether which resulted in increase in the amount of students with excessive weight. This was also facilitated by reduction of the level of motor activity in senior years when physical culture classes are no longer included into the curriculum. The dependence of growth processes in boys and girls at the age of 17-22 years on the level of motor activity was revealed that influenced the speed and direction of increment of the total dimensions of the body and the type of body-build. According to our data, the majority of boys support a high level of motor activity to buildup the body mass, and girls lead an active way of life to decrease the body mass and to keep it on the optimal level.
Comparative characteristics of emissions priority carcinogens by stationary sources into the air atmosphere of areas of the Ryazan region
Authors: Dementyev Aleksej A. , Lyapkalo Aleksandr A. , Tsurgan Aleksandr M. , Bulychova Galina N. , Korshunova Elena P.
Published: October 2019

Aim. Evaluation of dynamics of emission of priority carcinogens by stationary sources in the regions of the Ryazan region in 2009 and 2016.
Materials and Methods. For analysis, official statistical data about volumes of pollutants emitted by stationary sources into the atmospheric air, were used. The priority was determined by calculation of equivalent emission with taking into account the slope factor of carcinogenic potential in inhalation entry (SFi). The dynamics of emissions of carcinogens was evaluated by the growth rate.
Results. The study showed that priority chemical carcinogens released into the atmospheric air of municipal units by stationary sources included: chromium (Cr) (VI), carbon (soot), benzol, petrol and formaldehyde. From 2009 to 2016 a 39.4% decline in the total equivalent emission of carcinogens was reported, especially of benzol, soot and formaldehyde which considerably changed the structure of emission – a significant increase in the share of Cr (VI) (up to 55.7%, 1.5-fold) and almost twice reduction in the share of benzol (to 23.3%). In the reported years more than 90% of the total equivalent emission of carcinogens in the Ryazan district were formed by stationary sources of Ryazan and Skopin towns, of Ryazan and Skopin districts.
Conclusion. In most municipal units of the Ryazan district a reduction of the total equivalent emission was noted except in Aleksandro-Nevsky, Miloslavskoye, Pronsk, Zakharovo and Shilovo districts where emission increased. In Ryazan, against the background significant reduction of emission of soot and benzol by 81.7 and 69.4%, respectively, a 37.4% increase in the emission of formaldehyde into the atmosphere was recorded.
Assessment of effectiveness of training of respiratory musculature in patients with chronic obstructive pulmonary disease and obesity
Authors: Ovsyannikov Evgeniy S. , Budnevsky Andrey V. , Shkatova Yanina S.
Published: October 2019

Aim. To assess the influence of training of respiratory musculature on the expressiveness of symptoms, tolerance to physical loads, spirometric parameters and quality of life of patients with chronic obstructive pulmonary disease (COPD) and obesity.
Materials and Methods. The study included 52 patients with COPD (clinical group D) and obesity, of them 42 men and 10 women with the mean age 65.4±6.8 years and body mass index 33.6±2.9 kg/m2. The patients were divided to 2 groups: the main group with training of respiratory musculature (TRM) within 12 months using a respiratory exerciser, and the control group with simulation of TRM using the same exerciser, but with minimal load.
Results. In 12 months the patients of the main group showed a reliable reduction of dyspnea on mMRC scale (Modified Medical Research Council), improvement of health related quality of life on St. George’s Respiratory Questionnaire (SGRQ), increase in forced expiration volume in 1 second and in forced vital capacity of lungs, increase in the covered distance in 6-minute walk test, reduction of the average duration of hospitalization for exacerbation of COPD.
Conclusion. Taking into account the obtained data, TRM can be considered as an effective component of the lung rehabilitation program in patients with COPD.
Operations on working heart in lesion of left main coronary artery in acute coronary syndrome
Authors: Staroverov Ilia N. , Staroverov Ivan N. , Churakov Stanislav O. , Lonchakova Oksana M.
Published: October 2019

Aim. To study safety and effectiveness of operations on the working heart in patients with damage to the left main coronary artery (LMCA) and with acute coronary syndrome (ACS), to determine the optimal time for operation.
Materials and Methods. The work was based on the analysis of examination and treatment of 62 patients with damage to LMCA. Patients were divided to 2 groups depending on the kind of surgery: in the first group of patients (n=31) the operation was performed under cardiopulmonary bypass (CPB), in the second group (n=31) – on the working heart. The groups were comparable by the main clinico-demographic parameters. The risk for unfavorable outcome was determined on EuroSCORE II scale.
Results. Operation on the working heart in patients with damage to LMCA and ACS permitted to reduce the time of operation (253.44±36.84 against 188.13±45.37 min, p=0.0001), blood loss in postoperative period (607.00±432.34 ml against 413.21±167.08 ml, р=0.03), frequency of use of blood preparations (47.62% against 18.18%, р=0.04). However, the revascularization efficiency was higher in the group operated under CPB (2.93±0.8 against 2.29±0.82, р=0.005). Operations under CPB performed at later time (14-30 days) were associated with increased lethality. In operations on the working heart no lethal outcomes were reported.
Conclusion. Operations on the working heart are safe and effective in the early period after development of ACS. The optimal operation time under CPB is 7-14 days. Lethality and postoperative complications in operation on the working heart before 7 days, within 7-14 days, and after 14 days did not differ.
Analysis of regeneration mechanisms in auto ransplantation
Authors: Pronina Elena A. , Maslyakov Vladimir V. , Ivanov Aleksej N. , Stepanova Tat`jana V. , Popyhova Jera B.
Published: October 2019

Search for effective and available methods of stimulation of regenerative processes is a priority task of restorative medicine. Of high interest is a kind of biostimulation that induces activation of metabolic and reparative processes in the whole organism.
Aim. Generalization of the relevant literature data concerning possible mechanisms of biostimulation in transplantation of self tissues of an organism. The results of literature survey showed that there still remain many debatable questions concerning cellular and molecular mechanisms that underlie intermolecular interactions in the stage of regeneration. Stimulating effects of an autotransplant both in the zone of the transplant or in an organism in whole may be caused by mediators and signal molecules released in destruction of the autotransplant tissues and of its perifocal region, and also by bioactive substances produced by immune-competent and stem cells.
Conclusion. Tissue transplants may be used as inductors of production of biologically active substances and activators of immune and/or stromal cells. The latter, in turn, are producers of a number of chemical mediators required for large-scale regeneration. Therefore, a promising method of stimulation of regenerative processes is transplantation of self tissue. This method is characterized by simplicity, effectiveness and availability which evokes special interest and requires further study.
Clinical observation of paroxysmal atrioventricular reciprocal tachycardia in intermittent Wolff–Parkinson–White syndrome
Authors: Pavlova Natalya P. , Artemova Nina M. , Maksimtseva Elena A. , Uryasiev Oleg M.
Published: October 2019

Aim. To present potentials of electrocardiographic (ECG) research method in the diagnosis of paroxysmal tachycardia, as well as in the presence of additional conduction pathways (DPP). To demonstrate potentials of a trivial method for identification of the type of arrhythmia, the mechanism of occurrence, and topics of the additional conduction pathway in Wolf-Parkinson-White syndrome on a clinical example.
Conclusion. A widely available routine method of the ECG allows to determine the nature of arrhythmia, to choose the treatment tactics, to assess the prognosis of the disease, prior to performing complex invasive procedures.
OBTAINING CANDIDATE SALT TOLERANT WHEAT MUTANT LINES DERIVED FROM COMBINATION OF SODIUM AZIDE MUTAGENESIS AND SOMATIC EMBRYOGENESIS
Authors: ŞEN Ayşe , SARSU Fatma
Published: October 2019

Plant mutants are important bio-resources for crop breeding and functional gene studies. In the present study, conventional chemical mutagenesis technique was combined with somatic embryogenesis to obtain candidate salt tolerant mutant wheat lines. For this purpose, 0-5 mM Sodium Azide (NaN3) was applied for 30 minutes to embryonic calli under in vitro conditions to produce genetic variations in the bread wheat (Triticum aestivum L. cv. Adana 99). Treated and non-treated calli were put in somatic embryo induction media, and 3 and 4 mM NaN3 were determined as optimum mutation doses for somatic embryo induction. The obtained somatic embryos from these optimum mutagen doses were then screened for tolerance in regeneration media containing 125 mM NaCl to be used to improve tolerance to salt stress. In NaN3 treatment, 14 mutants with moderate salt tolerance were obtained. The results suggest that the in vitro technique in combination with chemical mutagenesis may be a useful approach for accelerating breeding strategies to create enough genetic variation in populations and to get fourth generation putative salt tolerant wheat mutant lines it less than 1.5 years.
Ethnopolitical Relations And Their Regulation In The Border Regions Of Russia (On The Example Of Krasnodar Region)
Authors:   Kuban State University, Baranov Andrey Vladimirovich , Skorobogatov Victor Viktorovich ,   Kuban State University
Published: October 2019

The work reveals the state and development trends of ethnopolitical relations in the conditions of the border regions of Russia (based on materials about the Krasnodar Territory). The analysis of the ques-tionnaires results and expert surveys (2016–2019), including multi-ethnic youth, is carried out. The au-thors reveal the disposition specifics of the ethno-politics subjects in the Krasnodar Territory, that is consisting in the increased influence of the Cos-sacks and national-cultural associations, in the terri-torial asymmetry of the influence of various ethnic groups. The causes of the relative stability of inter-ethnic relations, foreign policy and intra-regional risks of conflicts are reviewed. There is established the influence of international and interregional mi-gration on the development of ethno-political rela-tions in the region. Attention is paid to institutions and methods of regulating interethnic relations in the political sphere and conflict prevention. Rec-ommendations how to improve state national policy in the border regions of Russia are given.
The Perspectives Of 1c Soft Usage In Human Resources Departments Work
Authors:   Law and HR Department, Kuban State Technological University, Kurakova Tatiana Valerievna , Kurakova Sofia Viktorovna ,   Kuban State Technological University
Published: October 2019

The work touches upon opportunities that HR spe-cia-lists get while working with software ‘1C: Salary and HR-management’. The authors reveal the possi-bilities of using ‘1C: Salary and personnel manage-ment’ in the work of the personnel service or HR, namely in personnel processes documentation. The purpose of the work is to analyze the current needs of the personnel service, determine the extent that ‘1C: Salary and Personnel Management’ program satisfies them, and offer recommendations to im-prove 1C capabilities in the framework of personnel process management. The authors did not aim to provide a technical or technological solution for ‘1C: Salary and personnel management’. There is noted the importance of software for combining account-ing and personnel accounting. The authors exam-ined the forms of documents that the program al-lows to gene-rate, its shortcomings are also re-vealed. There were developed recommendations to improve program ‘1C: Salary and Human Resource Management’ to make the automation and quality of management of personnel processes better in the organizations.
The Category Of «Good Faith» In Law And The Criteria For Its Determination In The Fulfillment Of Contractual Obligations In Business
Authors:   Kurgan State University, Mayboroda Tatyana Yuryevna , Khramtsova Natalya Gennadyevna ,   Kurgan State University
Published: October 2019

The paper discusses the problems of determining the criteria of good faith in the fulfillment of contrac-tual obligations in entrepreneurship, attempts to understand this category and substantiates the conclusion about the need to specify this concept in legal science for its more precise application in prac-tice in entrepreneurial activities. The purpose of the work is to identify the main characteristics of the criteria of good faith in entrepreneurial activities, necessary to determine the place and role of the analyzed category in legal science and business practice. The authors used theoretical methods of formal and dialectic logic, historical and comparative legal methods. Based on the results of the study, it is proposed to amend and supplement the legisla-tion on entrepreneurial activities. It is noted that the criteria for distinguishing the category of good faith should be abided when characterizing it in the theo-ry of law and use in judicial practice. Those are the unity of the objective and subjective, the accentua-tion of moral and ethical principles.