bluuebunny/crossref_metadata_2025 huggingface dataset:
Machine Advice with a Warning about Machine Limitations: Experimentally Testing the Solution Mandated by the Wisconsin Supreme Court
Authors: Engel Christoph , Grgić-Hlača Nina
Published: January 2021

The Wisconsin Supreme Court allows machine advice in the courtroom only if accompanied by a series of warnings. We test 878 US lay participants with jury experience on fifty past cases where we know ground truth. The warnings affect their estimates of the likelihood of recidivism and their confidence, but not their decision whether to grant bail. Participants do not get better at identifying defendants who recidivated during the next two years. Results are essentially the same if participants are warned in easily accessible language, and if they are additionally informed about the low accuracy of machine predictions. The decision to grant bail is also unaffected by the warnings mandated by the Supreme Court if participants do not first decide without knowing the machine prediction. Oversampling cases where defendants committed violent crime does not change results either, whether coupled with machine predictions for general or for violent crime. Giving participants feedback and incentivizing them for finding ground truth has a small, weakly significant effect. The effect becomes significant at conventional levels when additionally using strong graphical warnings. Then participants are less likely to follow the advice. But the effect is counterproductive: they follow the advice less if it actually is closer to ground truth.
One Size Does Not Fit All: Relationships between Size of Family Forest Holdings and Owner Attitudes and Behaviors
Authors: Butler Brett J , Caputo Jesse , Robillard Amanda L , Sass Emma M , Sutherland Chris
Published: January 2021

An estimated 10 million families, individuals, trusts, and estates own 39 percent of the forestland in the United States, excluding interior Alaska. Using segmented regression, the relationships between size of forest holdings and the attitudes and behaviors of these family forest ownerships were tested using data from the 2018 iteration of the USDA Forest Service’s National Woodland Owner Survey. All 16 variables tested have significant relationships with size of forest holdings, and 13 have one or more breakpoints, ranging from 40 to 5,854 ac, where the relationships between the variables change. Timber as a reason for owning, timber harvesting activities, management plan, advice received, land certified, tax program participation, cost share, recreation, land tenure, recreation, taxes and heirs as concerns, land transfer, and income from forestland have positive relationships with size of forest holdings; resident ownership has a negative relationship; and wildlife as a reason for owning and owner age have mixed relationships.
PIV test of the flow field of a centrifugal pump with four types of impeller blades
Authors: Shi Baocheng , Zhou Kaili , Pan Jianpeng , Zhang XingKai , Ying Ruomeng , Wu Lijuan , Zhang Yindi
Published: January 2021

Flow fields for various impellers were measured using water and a two-phase liquid–solid mixture with a particle image velocimetry system in a centrifugal rotating frame in controlled conditions. After measuring absolute velocity vectors in impeller passages, the vectors were decomposed based on the triangle speed principle and the distribution of relative velocity vectors within the impeller was obtained. Then, the distribution of particles and their influence on the performance of different impellers were analyzed. The following conclusions were made from the comparison of relative velocity vector field: first, the wear on the outlet of blades can be mitigated effectively by reducing the outlet angle of impeller blades; second, the pump with a double-arc-shaped profile had a more uniform and stable flow field distribution and higher performance than that with a single-arc profile; and finally, the “jet–wake” structure can be improved significantly by using impellers with long and short blades, resulting in a remarkable reduction in energy loss and improvement in pump efficiency. We also found that solid particles were mainly distributed at the outlet of the impeller and volute wall, while the concentration distribution of large particles tended to match the pressure surface. This research can provide some theoretical guidance for the design and optimization of two-phase flow centrifugal pumps.
Postural orthostatic tachycardia syndrome following open thoracoabdominal aortic aneurysm repair
Authors: Manuel Lucy , Fong Laura S , Mamo Andrew , Varcoe Ramon , Saw Wilfred , Grant Peter
Published: January 2021

Postural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular autonomic disorder characterised by an excessive heart rate on standing and orthostatic intolerance. We present a rare case of a 38-year-old man who underwent open repair of a thoracoabdominal aortic aneurysm for a chronic Stanford type B aortic dissection whose recovery was complicated by POTS. He received blood transfusions and was commenced on metoprolol, fludrocortisone and ivabradine with significant improvement in his symptoms. Correct assessment of postoperative tachycardia including postural telemetry is the key to identifying this condition and its successful management.
Systems-based Strategies Improve Positive Screening Fecal Immunochemical Testing Follow-up and Reduce Time to Diagnostic Colonoscopy
Authors: Sadowski Brett W , Bush Allison M , Humes Ross , Cullen Priscilla , Hopkins Ida , Chen Yen-Ju , McCarthy John , Tritsch Adam M , Laczek Jeffrey T
Published: January 2021

Introduction

Fecal immunochemical testing (FIT) is the most commonly used colorectal cancer (CRC) screening tool worldwide and accounts for 10% of all CRC screening in the United States. Potential vulnerabilities for patients enrolled to facilities within the military health system have recently come to light requiring reassessment of best practices. We studied the impact of a process improvement initiative designed to improve the safety and quality of care for patients after a positive screening FIT given previously published reports of poor organization performance.

Methods

During a time of increased utilization of nonendoscopic means of screening, we assessed rates of colonoscopy completion and time to colonoscopy after positive FIT after a multi-faceted process improvement initiative was implemented, compared against an institutional control period. The interventions included mandatory indication labeling at the time of order entry, as well as utilization of subspecialty nurse navigators to facilitate rapid follow-up even the absence of a referral from primary care.

Results

Preintervention, 34.8% of patients did not have appropriate follow-up of a positive FIT. Those that did had a variable and prolonged wait time of 140.1 ± 115.9 days. Postintervention, a standardized order mandating test indication labeling allowed for proactive gastroenterology involvement. Colonoscopy follow-up rate increased to 91.9% with an average interval of 21.9 ± 12.3 days.

Conclusion

The addition of indication labels and patient navigation after positive screening FIT was associated with 57.1% absolute increase in timely diagnostic colonoscopy. Similar highly reliable systems-based solutions should be adopted for CRC screening, and further implementation for other preventative screening interventions should be pursued.
Magnetic field geometry and magnetospheric environment of the strongly magnetic Of?p star NGC 1624-2
Authors: Järvinen S P , Hubrig S , Schöller M , Küker M , Ilyin I , Chojnowski S D
Published: January 2021

NGC 1624-2 is an O7f?p star with a reported probable polar magnetic field strength ≥20 kG, which is the strongest magnetic field ever measured in an O-type star. We study the variability of the mean longitudinal magnetic field 〈Bz〉 and the mean field modulus 〈B〉 to obtain constraints on its field geometry. Only one magnetic pole is observable over the rotation cycle. The approximately sinusoidal variation of 〈Bz〉 and the ratio of the values of the extrema of 〈B〉 indicate that there is an important component of the field that is dipolar. The 〈Bz〉 values measured over the rotation cycle are in the range from −0.2 to 4.5 kG, whereas the values for 〈B〉 vary between 9 and 12 kG. The 〈Bz〉 values obtained using the O iii λ7455 emission line are in the range from 0.4 to 2.3 kG and show a variability pattern similar to that detected for the absorption lines. The fact that the phase of the 〈Bz〉 minimum coincides with the phase of the 〈B〉 maximum, indicates that the field structure must significantly depart from a centred dipole. Further, we discuss the nature of the observed variable Stokes V profiles corresponding to a longitudinal field of negative polarity detected in the emission He i lines and present the first magnetohydrodynamical numerical simulations of the gas flow in the magnetosphere of this star.
Mapping the tilt of the Milky Way bulge velocity ellipsoids with ARGOS and Gaia DR2
Authors: Simion Iulia T , Shen Juntai , Koposov Sergey E , Ness Melissa , Freeman Kenneth , Bland-Hawthorn Joss , Lewis Geraint F
Published: January 2021

Until the recent advent of Gaia Data Release 2 (DR2) and deep multi-object spectroscopy, it has been difficult to obtain 6D phase space information for large numbers of stars beyond 4 kpc, in particular towards the Galactic Centre, where dust and crowding are significant. We combine line-of-sight velocities from the Abundances and Radial velocity Galactic Origins Survey (ARGOS) with proper motions from Gaia DR2 to obtain a sample of ∼7000 red clump stars with 3D velocities. We perform a large-scale stellar kinematics study of the Milky Way bulge to characterize the bulge velocity ellipsoids in 20 fields. The tilt of the major-axis of the velocity ellipsoid in the radial-longitudinal velocity plane, or vertex deviation, is characteristic of non-axisymmetric systems and a significant tilt is a robust indicator of non-axisymmetry or bar presence. We compare the observations to the predicted kinematics of an N-body boxy-bulge model formed from dynamical instabilities. In the model, the lv values are strongly correlated with the angle (α) between the bulge major-axis and the Sun-Galactic centre line of sight. We use a maximum likelihood method to obtain an independent measurement of α, from bulge stellar kinematics alone, performing a robust error analysis. The most likely value of α given our model is α = (29 ± 3)○, with an additional systematic uncertainty due to comparison with one specific model. In Baade’s window, the metal-rich stars display a larger vertex deviation (lv = −40○) than the metal-poor stars (lv = 10○) but we do not detect significant lv−metallicity trends in the other fields.
Analysis of galaxy kinematics based on Cepheids from the Gaia DR2 Catalogue
Authors: Bobylev V V , Bajkova A T , Rastorguev A S , Zabolotskikh M V
Published: January 2021

To construct the rotation curve of the Galaxy, classical Cepheids with proper motions, parallaxes and line-of-sight velocities from the Gaia DR2 Catalogue are used in large part. Our working sample formed from literature data contains about 800 Cepheids with estimates of their age. We determined that the linear rotation velocity of the Galaxy at the solar distance is V0 = 240 ± 3 km s−1. In this case, the distance from the Sun to the axis of rotation of the Galaxy is found to be R0 = 8.27 ± 0.10 kpc. A spectral analysis of radial and residual tangential velocities of Cepheids younger than 120 Myr showed close estimates of the parameters of the spiral density wave obtained from data both at the present time and in the past. Therefore, the value of the wavelength λR, θ is in the range [2.4–3.0] kpc, the pitch angle iR, θ is in the range [−13○, −10○] for a four-arm pattern model, and the amplitudes of the radial and tangential perturbations are fR ∼ 12 km s−1 and fθ ∼ 9 km s−1, respectively. Velocities of Cepheids older than 120 Myr currently give a wavelength λR, θ ∼ 5 kpc. This value differs significantly from the one we obtained from samples of young Cepheids. An analysis of the positions and velocities of old Cepheids, calculated by integrating their orbits backward in time, made it possible to determine significantly more reliable values of the parameters of the spiral density wave: wavelength λR, θ = 2.7 kpc and amplitudes of radial and tangential perturbations fR = 7.9 km s−1 and fθ = 5 km s−1, respectively.
The effects of drift and winds on the propagation of Galactic cosmic rays
Authors: AL-Zetoun A , Achterberg A
Published: January 2021

We study the effects of drift motions and the advection by a Galactic wind on the propagation of cosmic rays in the Galaxy. We employ a simplified magnetic field model, based on (and similar to) the Jansson–Farrar model for the Galactic magnetic field. Diffusion is allowed to be anisotropic. The relevant equations are solved numerically, using a set of stochastic differential equations. Inclusion of drift and a Galactic wind significantly shortens the residence time of cosmic rays, even for moderate wind speeds.
Phylogenomics of the Maverick Virus-Like Mobile Genetic Elements of Vertebrates
Authors: Barreat Jose Gabriel Nino , Katzourakis Aris
Published: January 2021

Mavericks are virus-like mobile genetic elements found in the genomes of eukaryotes. Although Mavericks encode capsid morphogenesis homologs, their viral particles have not been observed. Here, we provide new evidence supporting the viral nature of Mavericks and the potential existence of virions. To this end, we conducted a phylogenomic analysis of Mavericks in hundreds of vertebrate genomes, discovering 134 elements with an intact coding capacity in 17 host species. We reveal an extensive genomic fossil record in 143 species and date three groups of elements to the Late Cretaceous. Bayesian phylogenetic analysis using genomic fossil orthologs suggests that Mavericks have infected osteichthyans for ∼419 My. They have undergone frequent cross-species transmissions in cyprinid fish and all core genes are subject to strong purifying selection. We conclude that vertebrate Mavericks form an ancient lineage of aquatic dsDNA viruses which are probably still functional in some vertebrate lineages.
Arjun Appadurai
Authors: Hancock Mary , Weigler Elizabeth
Published: January 2021

Arjun Appadurai (b. 1949), currently Goddard Professor of Media, Culture, and Communication at New York University, is an interdisciplinary scholar whose work draws on the methods and theories of anthropology, history, political economy, and cultural studies. His scholarship, while originally rooted in area studies of South Asia, encompasses programmatic work aimed at formulating conceptual rubrics and questions to guide comparative and critical cultural studies of globalization, development, politics, and economy. He writes for audiences of scholars, creative practitioners, and activists, and for a broader public. A central intervention has been his framing of globalization in ways that privilege the work of imagination and futurity in its constituent processes and institutions; to this end, he has emphasized the mobility of ideas, images, finance, and persons and the durable domains of translocal interaction (e.g., ethnoscapes, finanscapes) that such mobility produces, while downplaying the territorial and cultural fixity of nation-states and localities. A signature rubric, “public culture,” advanced in his own work and especially in the journal of that name, co-founded and co-edited with his late wife, Carol Breckenridge, captures the malleable, contested, and multiply mediated notion of culture that underlies this understanding of globalization. This conception of culture is also meant to signal how hope and aspiration may be articulated with everyday worlds of meaning and action. Over the past four decades, his published work has encompassed books and edited collections, journal articles, chapters, and commentaries. Much of that work has derived from collaborative projects involving both original research and editorial activities, several associated with the journal, Public Culture, and with the Cultures of Finance Working Group, based at New York University. Appadurai also co-founded, with Carol Breckenridge, PUKAR (Partners for Urban Knowledge, Action, and Research), a Mumbai-based research collective that works with urban Indian communities who are grappling with local impacts of urbanization and globalization. Appadurai’s ideas about culture, globalization, development, commodification, identity politics, and postcolonialism have influenced scholarship in many fields, from his own core disciplines to media and communications studies, postcolonial studies, architecture, urban studies, and political theory.
John Hardyng
Authors: Peverley Sarah
Published: January 2021

The English chronicler John Hardyng (b. 1378–d. c. 1465) had a colorful career before settling down to write his two versions of British history in the 1450s and 1460s. Born in Northumberland, he served in the household of Sir Henry Percy (b. 1364–d. 1403) from the age of twelve, where he learnt the art of warfare and fought in numerous battles, including the Battle of Shrewsbury (1403). Later, he served Sir Robert Umfraville, fighting alongside him in Scotland and in the first years of Henry V’s French campaign (1415–1416). In 1418 Henry V sent Hardyng to Scotland to survey the topography of the realm and seek out evidence of English overlordship. Promised a substantial gift for his espionage, Hardyng returned after three and a half years, but Henry V’s untimely death deprived him of his prize. He remained unrewarded until the 1440s, when Henry VI honored the late king’s promise and granted Hardyng an annuity. By this time Hardyng’s patron, Sir Robert, was dead and Hardyng had taken up residence in the Augustinian Priory at Kyme, Lincolnshire. It was here that he began writing his first account of British history in Middle English verse. Surviving in a single manuscript, which was presented to Henry VI and his family in 1457 along with a map of Scotland and several of the Scottish documents recovered for Henry V, Hardyng’s Chronicle draws primarily on Geoffrey of Monmouth’s Historia Regum Britanniae, Robert Mannyng’s Chronicle, and a Latin Prose Brut to give an account of British and English affairs from the mythical founding of Britain by Brutus to 1437. Using the historical issue of English hegemony over Scotland as an ideological touchstone to unite divided Englishmen, the Chronicle sought to promote unity amidst the social, economic, and political instability that precipitated the Wars of the Roses. Within a few years of presenting the work and receiving another reward for his service, Hardyng began revising the text for Henry VI’s political rival, Richard, duke of York. The second Chronicle rewrote history to explain York’s superior claim to the throne, but it retained Hardyng’s call for unity among Englishmen and continued to use the issue of Scottish independence as a means of rallying his peers against a common foreign enemy. When the duke of York died in December 1460, Hardyng continued revising his text for York’s son, Edward IV, who took the throne from Henry VI in March 1461. Though Hardyng died before completing his revised narrative, numerous copies of the near-complete chronicle circulated in and around London in the 1460s and 1470s, helping to explain the Yorkist pedigree. It was the second version of the Chronicle that influenced Sir Thomas Malory’s Morte Darthur and which was later taken up by the Tudor printer Richard Grafton, who issued two prints in 1543 because of its relevance to the Anglo-Scottish wars in his own time. Grafton’s prints ensured the popularity of the Chronicle among Tudor historiographers and its influence on later writers, such as Shakespeare, Spenser, and Milton.
Strategy Implementation
Authors: Wohlgezogen Franz
Published: January 2021

Research on strategy implementation seeks to understand what activities organizations and their constituents engage in to put a formulated strategy into practice, what prompts a particular set and sequence of implementation activities, and what effect they have on the realization of a strategy and on organizational outcomes. Strategy scholars generally agree that deliberate and coordinated efforts to guide the translation of strategy from abstract plan and policy to organizational and behavioral reality are an integral aspect of strategic management and crucial for a strategy to improve an organization’s performance. Many also recognize that implementation is a dynamic and complex process that requires a degree of flexibility and iterative adjustment to respond to feedback or pushback from internal and external stakeholders. The strategy implementation literature is loosely held together by a shared phenomenological interest, and it has attracted an eclectic set of contributions from or made reference to diverse management subdisciplines beyond strategy, including organization studies, human resource management, operations management, accounting, and project management. Overall, theoretical advancement has been slow, and many of the frameworks and guidelines for implementation that are common in the practitioner literature have limited empirical evidence to support them. Likewise, many of the conceptual ambiguities, such as the demarcation between strategy formulation and implementation, and methodological challenges, such as the measurement of implementation outcomes, have not prompted systematic agendas or programs of research. This is a research area that offers plenty of opportunity for scholarly contributions. Please note that for a select few management techniques (e.g., total quality management, lean management, kaizen) and strategic vehicles (e.g., strategic alliances, mergers and acquisitions) specialized implementation research has accumulated. However, this article focuses on the nonspecialized domain, that is, on research that aims to develop a general body of knowledge related to implementation that is applicable for a wide range of strategies. Research from specialized domains is only selectively cited.
Electronic referrals to the tobacco Quitline: implementation strategies in a large health system to optimize delivery of tobacco cessation to patients
Authors: Khanna Niharika , Klyushnenkova Elena , Rao Vibha , Siegel Neil , Wolfe Sara
Published: January 2021

Electronic referrals provide an efficient solution for clinicians to connect patients to free tobacco cessation services, such as the tobacco Quitline. However, strategic planning is necessary for the successful adoption of this method across the health care system. The purpose of this study was to develop an implementation strategy for electronic referrals to the tobacco Quitline in a large health system. A clinical decision support tool created a closed-loop e-referral pathway between the electronic health record system and the Quitline. Multilevel strategies were developed to implement the e-referral process across the entire health system, including leadership buy-in, Epic tip sheets, newsletters, training for practice champions and staff, physician educator, patient-focused advertisements, and video clips distribution by the Maryland Department of Health Center for Tobacco Prevention and Control. The implementation of a system-wide e-referral pathway for tobacco cessation involved continuous clinician education and training, systematic quality control, and engaging “champion” clinicians. Postimplementation data analysis revealed that 1,790 e-referrals were received by the Quitline in 2018–2019, of which 18% accepted follow-up services, 18% declined, and 64% were not reached after multiple attempts. Among 322 patients who accepted Quitline services, 55% requested nicotine replacement therapy. Overall, 282 clinicians referred patients, including 107 primary care physicians and 175 specialists; 62 clinicians e-referred 72% patients, thereby emerging as “tobacco champions.” The e-referral process is an efficient method for tobacco users to receive a cessation referral from clinicians. Sustainability can be achieved through leadership buy-in, physician ease of use, patient motivation, information technology supports, and reminders.
Feasibility of an mHealth self-management intervention for children and adolescents with sickle cell disease and their families
Authors: Phillips Shannon , Kanter Julie , Mueller Martina , Gulledge Amy , Ruggiero Kenneth , Johnson Mary , Kelechi Teresa J
Published: January 2021

Sickle cell disease (SCD) is an inherited hemoglobinopathy that leads to blood vessel occlusion and multiorgan complications, including pain, that may be experienced daily. Symptom management often begins at home, and tools are needed to support self-management strategies that can be implemented by children with SCD and families. The purpose of this study was to assess the feasibility of the mHealth self-management intervention (application) Voice Crisis Alert V2 for children with SCD and families. Feasibility assessment was guided by the Reach, Efficacy, Adoption, Implementation, and Maintenance framework. Data were collected with 60 dyads (children with SCD/caregivers) at four time points. Self-management data were collected via application use, and postintervention interviews were conducted. Analyses included descriptive statistics and constant comparison with directed content analysis. Recruitment was completed in 28 weeks, with 82% retention at end-of-intervention. Mobile Application Rating Scale scores and interview data indicated high satisfaction. From baseline to mid-intervention, 94% of dyads used the application (75% of total use); 45% used the application from mid-intervention to the end-of-intervention. Dyads made 2,384 actions in the application; the most commonly used features were recording health history and recording and tracking symptoms. Few reported issues with the application; most issues occurred early in the study and were corrected. After the intervention period was completed, 37% continued to use the application. Feasibility was confirmed by meeting recruitment and retention goals, high adoption of the application, and high reported satisfaction with the application. Challenges with sustained use were encountered, and areas for improvement were identified.
Physical distancing ≠ physical inactivity
Authors: Meyer Stefanie M , Landry Matthew J , Gustat Jeanette , Lemon Stephenie C , Webster Collin A
Published: January 2021

During this time of global health crisis, physical distancing, along with mask wearing, has emerged as the sine qua non social practice to protect ourselves and others from COVID-19. But as physical distancing ensues and all eyes remain fixed on the novel coronavirus, another, albeit careworn, pandemic rages on. Physical inactivity, the world’s fourth leading cause of death, may indeed be exacerbated by physical distancing measures, such as sheltering at home and closing or limiting access to recreation and exercise facilities. The purpose of this paper is to urge public health and medical professionals not to forget the importance of physical activity to whole-person health, recognize the importance of physical activity as a potential COVID-19 mitigation strategy and to serve as advocates for promoting active lifestyles. It is imperative that the national call for physical distancing not be interpreted as a call for physical inactivity.
Behavioral Deficits in Mice with Postnatal Disruption ofNdel1in Forebrain Excitatory Neurons: Implications for Epilepsy and Neuropsychiatric Disorders
Authors: Gavrilovici Cezar , Jiang Yulan , Kiroski Ivana , Sterley Toni-Lee , Vandal Milene , Bains Jaideep , Park Sang Ki , Rho Jong M , Teskey G Campbell , Nguyen Minh Dang
Published: January 2021

Dysfunction of nuclear distribution element-like 1 (Ndel1) is associated with schizophrenia, a neuropsychiatric disorder characterized by cognitive impairment and with seizures as comorbidity. The levels of Ndel1 are also altered in human and models with epilepsy, a chronic condition whose hallmark feature is the occurrence of spontaneous recurrent seizures and is typically associated with comorbid conditions including learning and memory deficits, anxiety, and depression. In this study, we analyzed the behaviors of mice postnatally deficient for Ndel1 in forebrain excitatory neurons (Ndel1 CKO) that exhibit spatial learning and memory deficits, seizures, and shortened lifespan. Ndel1 CKO mice underperformed in species-specific tasks, that is, the nest building, open field, Y maze, forced swim, and dry cylinder tasks. We surveyed the expression and/or activity of a dozen molecules related to Ndel1 functions and found changes that may contribute to the abnormal behaviors. Finally, we tested the impact of Reelin glycoprotein that shows protective effects in the hippocampus of Ndel1 CKO, on the performance of the mutant animals in the nest building task. Our study highlights the importance of Ndel1 in the manifestation of species-specific animal behaviors that may be relevant to our understanding of the clinical conditions shared between neuropsychiatric disorders and epilepsy.
Chlorogenic acid abates oxido-inflammatory and apoptotic responses in the liver and kidney of Tamoxifen-treated rats
Authors: E Owumi Solomon , K Olusola Joseph , O Arunsi Uche , K Oyelere Adegboyega
Published: January 2021

Plant-derived phenolics are utilized as chemopreventive agents to abate adverse toxic responses associated with drug-induced damages. Tamoxifen (TAM)—a chemotherapeutic agent—is used in managing all stages of hormone-dependent breast cancer. Notwithstanding TAM’s clinical side effect—including hepatic toxicity—its use is commonplace. The present study investigates the effect of Chlorogenic acid (CGA: 25 and 50 mg kg−1; per os (p.o)) reported to exhibit various beneficial properties, including antioxidative effect against TAM (50 mg/kg; p.o.)-induced hepatorenal toxicities in rats treated as follows: Control, CGA, or TAM alone, and rats co-treated with CGA and TAM for 2 weeks. Biomarkers of hepatorenal function, oxido-inflammatory stress, and hepatorenal histopathology were performed. We observed that TAM alone decreased relative organ weights (ROW), marginally impacted rat’s survivability, and significantly (P < 0.05) increased hepatorenal toxicities and reactive oxygen and nitrogen species (RONS). TAM decreased (P < 0.05) antioxidant, anti-inflammatory cytokine (IL-10), besides increase in (P < 0.05) lipid peroxidation (LPO), pro-inflammatory cytokines (IL-1β, TNF-α), nitric oxide (NO), xanthine oxidase (XO), myeloperoxidase (MPO), and apoptotic caspases (Casp-3 and -9) levels. These biochemical alterations were accompanied by morphological lesions in experimental rats’ liver and kidney. Conversely, that CGA dose-dependently relieved TAM-mediated toxic responses, restored antioxidants capacities, reduced oxidative stress, pro-inflammatory cytokines levels, and Casp-3 and -9 activities in experimental rats. Furthermore, CGA protected against lesions observed in the liver and kidney of rats treated with TAM alone. Overall, CGA blocked TAM-mediated hepatorenal injuries associated with pro-oxidative, inflammatory, and apoptotic mechanisms. CGA may serve as a chemoprotective agent boosting patients prognosis undergoing TAM chemotherapy.
Assessing Opportunities for Solar Lanterns to Improve Educational Outcomes in Off-Grid Rural Areas: Results from a Randomized Controlled Trial
Authors: Stojanovski Ognen , Thurber Mark C , Wolak Frank A , Muwowo George , Harrison Kat
Published: January 2021

Solar lanterns are promoted across rural Sub-Saharan Africa as a way to improve educational outcomes. A randomized controlled trial in Zimba District, Zambia, evaluates whether solar lanterns help children study and improve academic performance. The research design accounts for potential income effects from receiving a lantern and also “blinds” participants to the study's purpose. There is no relationship detected between receipt of a solar lantern and improved performance on key examinations. Impacts on self-reported study habits are also not observed. A cost-effectiveness analysis suggests that solar lanterns are not an efficient way to improve educational outcomes in developing countries relative to other available options. Two phenomena, both of which are likely observed in other developing regions, may explain these results. First, flashlights have become the dominant lighting source in rural Zambia, so solar lanterns may have only limited appeal for prospective users who no longer rely on traditional lighting options like kerosene lamps. Second, improved energy access – whether through solar lanterns or other technologies – appears to be a relatively unimportant educational input in settings like Zimba.
Suggestions for Improvement in Psychometric Corrections in Meta-analysis and Implications for Research on Worker Age and Aging
Authors: Oh In-Sue , Schmidt Frank L
Published: January 2021

As a vital tool for advancing cumulative science and guiding evidence-based practice, meta-analysis has advanced many research fields of the behavioral and social sciences, including worker age and aging. Nonetheless, there is still room for improvement, particularly in terms of meta-analytic methods and procedures. In this article, we overview some influential meta-analyses on worker age and aging concerning their psychometric correction methods and procedures, identify potential controversies and issues, and offer suggestions for improvement, particularly in corrections for two major methodological artifacts (i.e., range variation and measurement error). We also debunk some myths that both researchers and journal reviewers may encounter regarding how to conduct psychometric meta-analyses and discuss implications and agendas for future research on worker age and aging. We hope this article will help researchers in the field of age and aging and beyond to conduct a psychometric meta-analysis while harnessing the benefits of psychometric corrections and meta-analysis.
Cortical Restricted Diffusion From Arrest to Mad Cow: A Clinicoradiologic Approach
Authors: Tork Craig A. , Cloran Francis J.
Published: January 2021

Diffusion-weighted imaging (DWI) is a powerful tool in MRI of the brain. DWI assesses the ability of water molecules to freely move within tissues through Brownian motion. Water that is extracellular has rapid diffusivity, whereas water within an intracellular compartment has decreased diffusivity. DWI assesses the ease with which these water molecules diffuse from the intracellular to extracellular compartments and out of the region of interest through phase and refocusing gradients, and imaging will demonstrate a hyperintense signal when the molecules are unable to freely diffuse.
Systematic Review of Autonomic Nervous System Functioning in Pediatric Chronic Pain
Authors: Gibler Robert C. , Jastrowski Mano Kristen E.
Published: January 2021

Objectives:

Chronic pain is a common and debilitating health problem that impacts up to one third of children and adolescents. The pathophysiological mechanisms of chronic pain are complex, but considerable research links dysfunction of the autonomic nervous system (ANS) and chronic pain in adults. No review of ANS functioning has been conducted in pediatric chronic pain. We systematically reviewed studies examining ANS activity among youth with primary chronic pain conditions.

Methods:

A systematic search of PsycINFO, PubMed, and CINAHL was conducted using specific search terms. Articles were included if studies measured heart rate, blood pressure, heart rate variability, galvanic skin responses, or pupillometry among children or adolescents with a chronic pain condition. Studies examining these factors in the context of a specific disease-related pain condition were excluded.

Results:

Of the 1304 articles screened, 15 studies met the criteria for inclusion in this review. All included studies were cross-sectional and primarily included youth with abdominal pain. Results revealed preliminary evidence of reduced parasympathetic activity among youth with pain as measured by heart rate variability. However, results were mixed across ANS indices. Measurement and procedural differences, in addition to a lack of control groups in some studies, limit the interpretability of the reviewed findings.

Discussion:

Additional studies with larger and more diverse samples of youth with various chronic primary pain conditions are needed to delineate possible relationships among ANS functioning and the development and maintenance of chronic pain in children and adolescents. Clinical implications and avenues for future research are discussed.
Acetabular Coverage Decreases at the End of Skeletal Growth: A 3DCT Study of Healthy Hips
Authors: Herman Max , Krivoniak April , Ruh Ethan , Thakrar Darshit , Bosch Patrick , Wylie James D. , Ghodadra Anish , McClincy Michael P.
Published: January 2021

Background:

Abnormalities in size and position of the acetabulum have been linked to both developmental dysplasia of the hip and femoroacetabular impingement. Owing to its 3-dimensional (3D) complexity, plain radiography and cross-sectional studies [computed tomography (CT) and magnetic resonance imaging] have limitations in their ability to capture the complexity of the acetabular 3D anatomy. The goal of the study was to use 3D computed tomography reconstructions to identify the acetabular lunate cartilage and measure its size at varying ages of development and between sexes.

Methods:

Patients aged 10 to 18 years with asymptomatic hips and a CT pelvis for appendicitis were reviewed. Patients were stratified by sex and age: preadolescent (10 to 12), young adolescent (13 to 15), and old adolescent (16 to 18) in equal proportions. Materialise 3-matic was used to generate a 3D pelvic model, and the acetabular lunate cartilage surface area was calculated. The lunate cartilage was divided into anatomic segments: superior (11:00 to 1:00), anterior (1:00 to 4:00), and posterior (8:00 to 11:00). The femoral head surface area was calculated to control for patient size. Mixed effects models were generated predicting segment size where side was treated as a repeated measure. Absolute and relative (lunate cartilage to femoral head) models were generated.

Results:

Sixty-two patients (124 hips) were included. Females showed a significant decrease in femoral head coverage as age increased overall and in the 3 subsegments. The majority of changes occurred between the preadolescent and young adolescent groups. Males did not show an overall change, but the superior and anterior anatomic subgroups showed a significant decrease in coverage between the young and old adolescent groups. Male lunate cartilages were absolutely, but not relatively, larger than females. No clinically significant side-to-side differences were noted.

Conclusions:

The relative femoral head coverage by the acetabular lunate cartilage reduced with increasing age, suggesting the growth of the femoral head outpaces the acetabular lunate cartilage’s growth. This was more prominent in females. This study has important implications for expected acetabular coverage changes in the latter aspects of pediatric and adolescent development.

Level of Evidence:

Level III—diagnostic study.
The Five-item Modified Frailty Index is Predictive of 30-day Postoperative Complications in Patients Undergoing Spine Surgery
Authors: Pierce Katherine E. , Naessig Sara , Kummer Nicholas , Larsen Kylan , Ahmad Waleed , Passfall Lara , Krol Oscar , Bortz Cole , Alas Haddy , Brown Avery , Diebo Bassel , Schoenfeld Andrew , Raad Micheal , Gerling Michael , Vira Shaleen , Passias Peter G.
Published: January 2021

Study Design.

Retrospective cohort study.

Objective.

This study aimed to evaluate the utility of the modified frailty index (mFI-5) in a population of patients undergoing spine surgery.

Summary of Background Data.

The original modified frailty index (mFI-11) published as an American College of Surgeons National Surgical Quality Improvement Program 11-factor index was modified to mFI-5 after variables were removed from recent renditions.

Methods.

Surgical spine patients were isolated using current procedural terminology codes. mFI-11 (11) and mFI-5 (5) were calculated from 2005 to 2012. mFI was determined by dividing the factors present by available factors. To assess correlation, Spearman rho was used. Predictive values of indices were generated by binary logistic regression. Patients were stratified into groups by mFI-5: not frail (NF, <0.3), mildly frail (MF, 0.3–0.5), severely frail (SF, >0.5). Means comparison tests analyzed frailty and clinical outcomes.

Results.

After calculating the mFI-5 and the mFI-11, Spearman rho between the two indices was 0.926(P < 0.001). Each index established significant (all P < 0.001) predictive values for unplanned readmission (11 = odds ratio [OR]: 5.65 [2.92–10.94]; 5 = OR: 3.68 [1.85–2.32]), post-op complications (11 = OR: 8.56 [7.12–10.31]; 5 = OR: 13.32 [10.89–16.29]), and mortality (11 = OR: 41.29 [21.92–77.76]; 5 = OR: 114.82 [54.64–241.28]). Frailty categories by mFI-5 were: 83.2% NF, 15.2% MF, and 1.6% SF. From 2005 to 2016, rates of NF decreased (88.8% to 82.2%, P < 0.001), whereas MF increased (9.2% to 16.2%, P < 0.001), and SF remained constant (2% to 1.6%, P > 0.05). With increase in severity, postoperative rates of morbidities and complications increased.

Conclusion.

The five-factor National Surgical Quality Improvement Program modified frailty index is an effective predictor of postoperative events following spine surgery. Severity of frailty score by the mFI-5 was associated with increased morbidity and mortality. The mFI-5 within a surgical spine population can reliably predict post-op complications. This tool is less cumbersome than mFI-11 and relies on readily accessible variables at the time of surgical decision-making.

Level of Evidence: 3
MicroRNA-196b promotes gastric cancer progression by targeting ECRG4
Authors: Chen Liao , Tang Huirong , Liu Guobin , Xiao Shufeng , Liang Daoming , Ma Jun , Yang Yanlong , Luo Haibo , Zhu Yong , Xie Fujia , Cheng Xi , Chi Junlin , Wu Xuesong
Published: January 2021

Gastric cancer is one of the most common malignant tumors. MicroRNA-196b (miR-196b) has been demonstrated to play important roles in human cancers. However, its functions in gastric cancer progression were still largely unknown. In this study, the expression of miR-196b was determined by quantitative real-time PCR. Esophageal cancer-related gene 4 (ECRG4) level was examined by western blot assay and immunohistochemistry staining assay. Cell proliferation was evaluated by Cell Counting Kit-8 (CCK-8) assay and colony formation assay. Cell migration and invasion were analyzed by transwell assay. The association between miR-196b and ECRG4 was analyzed by dual-luciferase reporter assay. The functional role of miR-196b in vivo was analyzed by murine xenograft assay. As a result, we found the expression of miR-196b was elevated and the protein expression of ECRG4 was reduced in gastric cancer tissues and cells. MiR-196b inhibition suppressed gastric cancer cell proliferation, migration and invasion. ECRG4 was a target of miR-196b and its protein expression was negatively regulated by miR-196b. Moreover, ECRG4 overexpression showed similar effects with miR-196b inhibition on the malignant behaviors of GC cells and ECRG4 knockdown reversed the effects of miR-196b inhibition on gastric cancer cell proliferation, migration and invasion. In addition, miR-196b inhibition suppressed tumor volume and weight in vivo. In conclusion, downregulation of miR-196b inhibited gastric cancer progression by modulating ECRG4 expression, indicating that miR-196b might be a potential therapeutic target for gastric cancer.
Identification of the antidepressive properties of C1, a specific inhibitor of Skp2, in mice
Authors: Li Fu , Huang Chao , Lu Xu , Xiang Haitao , Wang Dan , Chen Zhuo , Chen Jinliang , He Haiyan , Yuan Xiaomei
Published: January 2021

We have reported that SMIP004, an inhibitor of S-phase kinase-associated protein 2 (Skp2), displays antidepressant-like activities in stress-naïve and chronically stressed mice. Here, we investigated the antidepressant-like effect of C1, another inhibitor of Skp2, in mouse models following acute or chronic drug administration at different doses and treatment times by using the tail suspension test (TST), forced swimming test (FST), and social interaction test (SIT). The time- and dose-dependent results showed that the antidepressant-like effect of C1 occurred 8 days after the drug treatment, and C1 produced antidepressant-like activities at the dose of 5 and 10 but not 1 mg/kg in male or female mice. C1 administration (5 mg/kg) also induced antidepressant-like effects in stress-naïve mice in a three-times administration mode within 24 h (24, 5, and 1 h before the test) but not in an acute administration mode (1 h before the test). The C1 and fluoxetine co-administration produced additive effect on depression-like behaviors in stress-naïve mice. The antidepressant-like effect of C1 was not associated with the change in locomotor activity, as no increased locomotor activity was observed in different treatment modes. Furthermore, the long-term C1 treatment (5 mg/kg) was found to ameliorate the depression-like behaviors in chronic social defeat stress-exposed mice, suggesting that C1 can produce antidepressant-like actions in stress conditions. Since C1 is a specific inhibitor of Skp2, our results demonstrate that inhibition of Skp2 might be a potential strategy for the treatment of depression, and Skp2 may be potential target for the development of novel antidepressants.
Multimodal Radiofrequency Application for Lower Face and Neck Laxity
Authors: Dayan Erez , Rovatti Paolo , Aston Sherell , Chia Christopher T. , Rohrich Rod , Theodorou Spero
Published: January 2021

Background:

Nonexcisional facial skin tightening has long been an elusive goal in aesthetic surgery. The “treatment gap” includes cases who are not “severe” enough for excisions surgery but not “mild” enough for most traditional noninvasive aesthetic modalities. In this retrospective review, we present the largest evaluation to date of radiofrequency (RF) skin tightening technology combination including bipolar RF (FaceTite; InMode) and fractional bipolar RF (Fractora modified to Morpheus8; InMode).

Methods:

A multicenter retrospective study was conducted between January 2013 and December 2018 using a combination of bipolar RF and fractional bipolar RF for the treatment of facial aging. Data collection included demographic information, Baker Face/Neck Classification, amount of energy used, adverse events, and patient satisfaction. Four cadaver dissections were also conducted to correlate the underlying neuromuscular anatomy with RF treatment of the lower face and neck.

Results:

Two hundred forty-seven patients (234 women and 13 men) were included in the study. Average age was 55.1 years (SD, ±8), body mass index was 24.3 (±2.4), and 9% (23/247) of patients were active smokers at the time of treatment. Patients had an average Baker Face/Neck Classification score of 3.1 (SD, ±1.4). The procedure was performed under local anesthesia in 240/247 cases (97.2%). Patients objectively improved their Baker Face/Neck Classification score by 1.4 points (SD, ±1.1). Ninety-three percent of patients indicated that they were pleased with their results and would undergo the procedure again. Complications recorded for our cohort included prolonged swelling >6 weeks (4.8%, 12/247), hardened area >12 weeks (3.2%, 8/247), and marginal mandibular neuropraxia (1.2%, 3/247), which all resolved without further intervention. When considering possible control variables, age seems to be a significant factor. That is, older patients were more likely to benefit from a larger magnitude of the treatment effect (as demonstrated by a decrease in the Baker rating from pre- to posttreatment) when compared with younger patients. However, both groups did demonstrate significant improvements across time.

Conclusion:

While this combination RF treatment (FaceTite bipolar RF and fractional bipolar RF) does not aim to replace a facelift/necklift in appropriate candidates, it does broaden the plastic surgeons’ armamentarium to potentially fill a treatment gap.