Introduction: The association of depressive and apathetic symptoms after lesions in the frontal region in the territory of the anterior cerebral artery is described, presumably due to interruption of complex subcortical frontal circuits. Objectives: Illustrate and discuss a bilateral frontal syndrome resulting from stroke in the territory of the anterior cerebral artery, as well as, the possible confusion between functional and organic conditions presenting the same symptoms. Results: 61-year-old man complaining of falls and left lower limb weakness. Moreover, had been interned due to suicide attempt recently. He is hypertensive and was addicted to alcohol and illicit drugs. Two years before, he had a left anterior cerebral artery ischemic that led to right lower limb paresis. At admission, he had poor interaction and presented hyperreflexia and Babinski sign at the right lower limb while normoreflexia at left. Computed tomography (CT) of the skull showed left frontal encephalomalacia. It was discarded metabolic and infectious disturbance as well as no signs of trauma from reported falls or high-risk lesions for new stroke. Psychiatric evaluations identified depression related to social, and economic factors. Pharmacological and behavioral measures were instituted. However, the condition worsened with the onset of mutism, akinesia, and abulia, which was attributed to the wors ening of depression. Antidepressant regimen was adjusted again and new brain CT was performed. It disclosed a new stroke of the right anterior cerebral artery. Initially, the symptoms were attributed to a functional condition and no organic justification was found. Nevertheless, the worsening of the basal status evolved to a catatonic manifestation, in parallel to a new frontal stroke. Previous contralateral frontal stroke might have turned the patient vulnerable to this condition. Nonetheless, the course of time eased by pharmacological strategy used (lithium, amitriptyline, and risperidone), was able to reverse the condition, except for left leg monoplegia evidenced after the restoration of spontaneous motricity. Conclusion: The case illustrates the clinical-anatomical correlations of anterior cerebral artery stroke, but also highlights the interface between neurology and psychiatry.
Authors: Poton André Rodrigues , Ferreira Ana Carolina Andorinho de Freitas , Goldschmidt Leila Delorme , Dalla Maria Fiorot , Amorim Barbara França , Patroclo Cristiane Borges 
Published: July 2023

Introduction: The association of depressive and apathetic symptoms after lesions in the frontal region in the territory of the anterior cerebral artery is described, presumably due to interruption of complex subcortical frontal circuits. Objectives: Illustrate and discuss a bilateral frontal syndrome resulting from stroke in the territory of the anterior cerebral artery, as well as, the possible confusion between functional and organic conditions presenting the same symptoms. Results: 61-year-old man complaining of falls and left lower limb weakness. Moreover, had been interned due to suicide attempt recently. He is hypertensive and was addicted to alcohol and illicit drugs. Two years before, he had a left anterior cerebral artery ischemic that led to right lower limb paresis. At admission, he had poor interaction and presented hyperreflexia and Babinski sign at the right lower limb while normoreflexia at left. Computed tomography (CT) of the skull showed left frontal encephalomalacia. It was discarded metabolic and infectious disturbance as well as no signs of trauma from reported falls or high-risk lesions for new stroke. Psychiatric evaluations identified depression related to social, and economic factors. Pharmacological and behavioral measures were instituted. However, the condition worsened with the onset of mutism, akinesia, and abulia, which was attributed to the wors ening of depression. Antidepressant regimen was adjusted again and new brain CT was performed. It disclosed a new stroke of the right anterior cerebral artery. Initially, the symptoms were attributed to a functional condition and no organic justification was found. Nevertheless, the worsening of the basal status evolved to a catatonic manifestation, in parallel to a new frontal stroke. Previous contralateral frontal stroke might have turned the patient vulnerable to this condition. Nonetheless, the course of time eased by pharmacological strategy used (lithium, amitriptyline, and risperidone), was able to reverse the condition, except for left leg monoplegia evidenced after the restoration of spontaneous motricity. Conclusion: The case illustrates the clinical-anatomical correlations of anterior cerebral artery stroke, but also highlights the interface between neurology and psychiatry.