bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of packaging material and postharvest calcium treatment on weight loss, decay and biochemical quality of strawberry fruits during storage
Authors: Kumar Rakesh , Antil R. S. , Ali Angrej
Published: December 2021

Strawberry (Fragaria x ananassa Duch.) fruits are highly perishable which lose their marketability within a short period of time, resulting in considerable loss of fruits after harvest. In present study, the packaging materials treatment i.e. polypropylene terephthalate (PET) Punnet and High density polythene (HDPE) crates and calcium compounds (CaCl2 and Ca(No3)2) were examined for the storability and biochemical quality of strawberry (cv. Winter Down) fruits in cold condition (3±1 °C) in comparison to the untreated control fruit in ambient storage for 3, 6 and 8 days storage period. Results revealed that physiological loss in weight (PLW) and fruit decay increased with the advancement of the storage period irrespective of the treatments. Fruits treated with CaCl2 (2%), packed in PET Punnets and stored in cold condition (3±1 °C) showed significantly minimum PLW (6.55, 11.12 and 15 34 %) and fruit decay (7.29, 17.71 and 34.38 %) at 3, 6 and 8 days storage, respectively. Non-treated control fruits at ambient conditions could not maintain their marketability even 3 days of storage and showed relatively high decay losses (25.00, 62.21 and 91.67 % at 3, 6 and 8 days of storage, respectively). Packaging and calcium treatment did not affect the fruit total soluble solids (TSS) and total sugars but was found effective to slow down the decrease of ascorbic acid and acidity contents of the fruit during storage. PET Punnets packaged fruits treated with CaCl2 (2%) under cold conditions retained better shelf-life with better biochemical quality of fruits during storage while untreated control fruits deteriorated rapidly.
A comparison of mutagenic potential of Aji-no-Moto with a traditional chemical mutagen on microsporogenesis in barley (Hordeum vulagre L.)
Authors: Singh Vivek
Published: December 2021

Aji-no-Moto or Mono Sodium Glutamate (MSG) is a flavour enhancer being used extensively in South East Asian cuisine. The Federation of American Societies for Experimental Biology for the United States Food and Drug Administration (FDA) has concluded that MSG is safe when "eaten at customary levels" but there is still great confusion regarding its toxicity at higher concentrations. Therefore, it was decided to assess the mutagenic efficacy of MSG on a plant system and present the findings as a model for probably similar effects in the animal model. For this, a traditionally popular genus for genetic studies, Hordeum vulgare L. or winter barley, was used as the model system. The studies of microsporogenesis were done in order to see the long term effect. The sets were compared with experimental sets of plants grown from seeds treated with a traditional chemical mutagen Ethyl Methane Sulphonate (EMS). The study revealed that MSG does not induce much genotoxic effects at lower doses and the chromosomal damages induced were very few. However, at higher doses, it almost equals the effects of EMS in terms of heritable genetic damage. The work is significant as MSG continues to be one of the most popular flavouring agents and does not face any challenge to its biosafe status. However, the clastogenic and chromotoxic effects of higher doses of MSG as observed in the study are in total contradiction to the popular belief.
Sulphur fertilization on biochemical constituents of cabbage (Brassica oleracea var. capitata. L) in non-calcareous soil of Coimbatore district, Tamil Nadu
Authors: Roshini S. , Jegadeeswari D. , Chitdeshwari T. , Sankari A.
Published: December 2021

Sulphur is the fourth most important plant nutrient after nitrogen, phosphorus, and potassium, and it is becoming increasingly crucial in high-quality crop production (Bhoyar., 2019). Since limited work has been carried out regarding different sulphur sources on cabbage production in the Coimbatore district, the present study was undertaken to investigate the sulphur sources and levels on various biochemical constituents of cabbage. Hence a  field experiment was conducted in the farmer’s field at Viraliyur village, Thondamuthur block of Coimbatore district, Tamil Nadu to assess the effect of sulphur fertilization on improving the biochemical constituents of cabbage hybrid Saint. There were four different S sources (Elemental sulphur, Potassium sulphate, Gypsum, Single super phosphate) applied at five levels (0, 20, 40, 60 and 80 kg ha-1) and replicated thrice in a factorial randomized block design. The crop was fertilized with a  Soil Test Crop Response-prescribed dose of NPK (200:125:25 kg ha-1). The crop was harvested on 90th day and cabbage heads were analysed for various biochemical constituents like ascorbic acid, total soluble solids (TSS), titratable acidity (TA), chlorophyll content, glucosinolates (GLs), total phenol content (TPC), sulphur containing amino acid (methionine) and antioxidant enzyme activity (peroxidase). The influence of S fertilizers on biochemical constituents increased significantly with increasing levels of sulphur fertilization up to 80 kg S ha-1 excluding ascorbic acid content. The pooled data showed that gypsum applied at 80 kg ha-1 registered the maximum GLs (69.0 µmol g-1), TPC (31.9 mM 100g-1), methionine (32.3%), peroxidase activity (0.70 units min-1mg-1), TSS (7.64 0Brix), TA (0.64%), ascorbic acid (61.4 mg 100g-1) and total chlorophyll (1.21 mg g-1) in cabbage head. The lowest content of biochemical constituents viz., GLs (34.1 µmol g-1), TPC (8.10 mM 100g-1), methionine (17.6%) and peroxidase (0.31 units min-1mg-1) were observed in control applied NPK alone. There were positive and significant changes in the biochemical constituents of cabbage due to S application which confirms the improvement in the quality of cabbage head. The study concluded that gypsum was  the better sulphur source for improving the quality of cabbage.
Study of potential activity of clove oil 10 % emulsifiable concentrate formulation on Two-spotted spider Mite Tetranychus urticae Koch (Acari: Tetranychidae)
Authors: Abd-Alla Hisham I. , Hamouda Saad E. S.
Published: December 2021

Clove oil is reported to have a great range of biological activities against many species of pests; termites, cockroaches, aphids, weevils and moths, and many different usages such as perfume and food flavoring agent. This study aimed to determine the acaricidal activity of clove oil emulsifiable concentrate new formulation against two-spotted spider mites Tetranychus urticae. Clove oil was formulated as 10 % emulsifiable concentrate (EC). The new formula passed successfully all physical and chemical tests reported for emulsifiable concentrates. It was then tested biologically on the individuals of two-spotted spider mite T. urticae Koch (Acari: Tetranychidae) on two host plants beans and squash under laboratory conditions. In both cases, there were a direct relationship between the increase in the concentration of the formulation and the percentage of inhibition on the individuals of the two-spotted spider mite, after 72 hours of treatment, at concentrations of 20, 40, and 80 mg/ml the new formulation showed 10.30, 44.8, and 75 percent inhibition, respectively in case of beans, while squash at the same concentrations and for the same period of treatment showed 33.3, 40.7, and 51.9 percent inhibition, but the effect in case of beans was greater than that in case of squash as its EC50 value was lower than that in case of squash. In the case of the former, it was 39.81 mg/ml, whereas in the case of the latter, it was 79.43 mg/ml. Therefore, the new clove oil formulation can be used to combat the two-spotted spider mite.
A IMPORTÂNCIA DA ROTINA NA EDUCAÇÃO INFANTIL E SUA INFLUÊNCIA NA APRENDIZAGEM COGNITIVA
Authors: Fardin Covre Edna Sidineia
Published: December 2021

A rotina é a base da vida diária. E o diário constitui nosso sentido do tempo, da história e do futuro tanto pessoal como coletivo. A vida cotidiana é a situação mais próxima e mais estável para os seres humanos especialmente se são crianças. No espaço de cada dia, no ritmo e onde ocorre ao longo de cada jornada é onde se realiza seu desenvolvimento, com suas necessidades e desejos, sentimentos e emoções, e também com tudo o que ocorre em seu ambiente e com as descobertas e experiências que ela vive. Hoje em dia estamos imersos numa sociedade de mudança e muitas vezes, carente de valores. Por esta razão, com este trabalho pretende-se enfatizar a possibilidade e a importância de seu tratamento desde as idades mais precoces, e em coordenação com toda a comunidade educativa. A partir da perspectiva pedagógica, a vida cotidiana é um dos grandes recursos educativos com os quais se pode e se deve contar o educador desta etapa, facilitando aos pequenos a aquisição de bons hábitos pessoais e sociais. Este artigo trata da importância da rotina na educação infantil e sua influencia na aprendizagem cognitiva indicando como trabalhar com crianças, o conhecimento de si mesmo e a autoestima, evitando preconceitos e aprendendo a colaborar.
Artificial intelligence in the diagnosis and detection of heart failure: the past, present, and future
Authors: Yasmin Farah , Shah Syed Muhammad Ismail , Naeem Aisha , Shujauddin Syed Muhammad , Jabeen Adina , Kazmi Sana , Siddiqui Sarush Ahmed , Kumar Pankaj , Salman Shiza , Hassan Syed Adeel , Dasari Chandrashekhar , Choudhry Ali Sanaullah , Mustafa Ahmad , Chawla Sanchit , Lak Hassan Mehmood
Published: December 2021

Artificial Intelligence (AI) performs human intelligence-dependant tasks using tools such as Machine Learning, and its subtype Deep Learning. AI has incorporated itself in the field of cardiovascular medicine, and increasingly employed to revolutionize diagnosis, treatment, risk prediction, clinical care, and drug discovery. Heart failure has a high prevalence, and mortality rate following hospitalization being 10.4% at 30-days, 22% at 1-year, and 42.3% at 5-years. Early detection of heart failure is of vital importance in shaping the medical, and surgical interventions specific to HF patients. This has been accomplished with the advent of Neural Network (NN) model, the accuracy of which has proven to be 85%. AI can be of tremendous help in analyzing raw image data from cardiac imaging techniques (such as echocardiography, computed tomography, cardiac MRI amongst others) and electrocardiogram recordings through incorporation of an algorithm. The use of decision trees by Rough Sets (RS), and logistic regression (LR) methods utilized to construct decision-making model to diagnose congestive heart failure, and role of AI in early detection of future mortality and destabilization episodes has played a vital role in optimizing cardiovascular disease outcomes. The review highlights the major achievements of AI in recent years that has radically changed nearly all areas of HF prevention, diagnosis, and management.
Aspek Penilaian dalam Transaksi Pengalihan Hak atas Tanah dan/atau Bangunan
Authors: Irawan Ferry , Benu Ferdy Subaga
Published: December 2021

This research aims to review the implementation of the appraisal in the transaction of transferring rights to land and/or buildings at the Ciawi Small Tax Office (STO) and identify the constraints that arise in the field during the appraisal process. This study uses a descriptive qualitative approach in order to capture the process of valuation. The results showed that implementation of the appraisal in the transaction of transferring rights to land and/or buildings at the Ciawi Small Tax Office (STO) is carried out in six steps. These steps are: (1) identification of the problem, (2) data collection, (3) data analysis, (4) application of the approaches to value, (5) final opinion of value, and (6) report of defined value.

Keywords: Property Valuation, Transfer of Rights to Land and or Building, Valuation
Analisis Persepsi Manfaat Evaluasi Belanja K/L pada Satker Mitra Kerja KPPN Kediri
Authors: Suliantoro Irwan , Deviyani Auxiliadora Monica
Published: December 2021

Evaluasi terhadap belanja negara yang  dilakukan oleh satker dilaksanakan melalui Evaluasi Kinerja Anggaran  (menggunakan aplikasi SMART Ditjen Anggaran) dan eMonev (Bappenas). Kedua aplikasi tersebut mempunyai tujuan utama yang sama, yaitu  memberikan masukan  dalam rangka mendukung pengambilan kebijakan untuk peningkatan/perbaikan  kinerja. Kedua aplikasi tersebut digunakan oleh unit eselon 1 pusat dan oleh satker daerah. Namun demikian, terdapat perbedaan karakteristik pada unit eselon 1 pusat dengan satker daerah. Unit eselon 1 pusat merupakan entitas pembuat kebijakan, sedangkan satker daerah merupakan entitas pelaksana dari kebijakan yang dibuat oleh unit eselon 1 pusat. Dengan perbedaan karakteristik tersebut, maka perlu dilakukan survei bagaimana persepsi satker daerah terhadap manfaat Monev belanja K/L. Survei dilakukan pada satker-satker mitra kerja KPPN Kediri. Dari hasil survei, diketahui bahwa sebagian satker  mempunyai persepsi bahwa pengisian data Monev belanja K/L sebagai beban tambahan dan tidak/kurang dirasakan manfaatnya. Untuk meningkatkan persepsi manfaat Monev belanja K/L, maka perlu dibedakan kebutuhan informasi untuk unit eselon 1 pusat dengan satker daerah pada aplikasi SMART dan eMonev.
The Effect of Government Bonds, Inflation, And Exchange Rate in Achieving SDGs
Authors: Bakri Muhammad Rafi , Utami Anastasya
Published: December 2021

This study aims to examine the effect of bonds, inflation rates, and exchange rates on economic growth to achieve Indonesia's 2030 sustainable development goals, namely reducing government and poverty. This study uses a quantitative regression analysis method with a path analysis approach to determine the direct or indirect effect between variables. The variables used are published values, inflation, exchange rates, economic growth, poverty rates, and poverty in Indonesia in 2016-2020. Based on the path analysis, the coefficient of determination of 60.72% indicates that the diversity of the data of 60.72% can be explained in the model. Government Bonds have a direct and significant effect on the economic growth of -1,243. Government obligations indirectly affect the level of movement and mission of 1,098 and 1,128, respectively. The inflation rate directly affects the rate of economic growth of 0.712. The inflation rate has no direct effect on the movement level and poverty of -0.6294 and -0.6644. The exchange rate has no significant direct or indirect effect on economic growth, movement, and poverty. This study concludes that the government needs to control inflation and inflation so that the economy can be achieved and reduce inflation and poverty.
Keywords: Government Bond, Inflation Rate, Exchange Rate, Economic Growth, SDG’s
Evaluation of the effectiveness of diet therapy in the elderly with obesity and non-alcoholic fatty liver disease
Authors: Lapik I. A. , Chekhonina Y. G. , Korotkova T. N. , Gapparova K. M.
Published: December 2021

The aim of the study was to evaluate the effectiveness of a standard reduced-calorie diet in elderly subjects with obesity and nonalcoholic fatty liver disease (NAFLD).

Materials and Methods: 60 women with I-III degree obesity and NAFLD were examined. Metabolic status was assessed by indirect calorimetry and body composition indices using bioimpedance spectroscopy. Biochemical indices in blood serum were determined on a biochemical analyzer “KONELAB Prime 60i”. SPSS Statistics 23.0 program was used for statistical data processing.

Results and Discussion: It was found that resting energy expenditure was significantly higher in middle-aged women (1896.8±46.5 kcal/d) with obesity and NAFLD than in elderly women (1691.6±34.2 kcal/d). Fat oxidation rate was significantly lower in elderly women (66.8±7 g/day) than in middle-aged women (70.8±9 g/day). The elderly patients received a variant of the standard diet with reduced caloric content for 10 days. Against the background of diet therapy, a significant decrease in glucose, total cholesterol, LDL, triglycerides, as well as fat mass, total fluid and visceral fat area was observed in elderly patients with obesity and NAFLD. However, the use of a standard reduced-calorie diet resulted in a slight elevation of serum uric acid levels and a significant decrease in muscle mass.

Conclusions: the selection of specialized diets is recommended for elderly patients with obesity and NAFLD when prescribing diet therapy, which will not only prevent the decrease of muscle mass and increase of uric acid but also improve the effectiveness of treatment measures in obesity by preventing the development and progression of its complications.
Thyrotoxic hepatitis during pregnancy (clinical case)
Authors: Aparkina A. V. , Kashkina E. I. , Markova A. A. , Azarkina K. S. , Darbinayn V. O.
Published: December 2021

A rare clinical case of thyrotoxic hepatitis detected in a pregnant woman is presented. A diagnostic search was carried out to clarify the cause of hepatitis, during which the pathology of the thyroid gland was revealed. The patient was prescribed adequate therapy with a thyrostatic drug, which in a short time allowed to achieve a significant decrease in the activity of the hepatic pathological process, which made it possible to prolong pregnancy.
Non-alcoholic fatty liver disease as an independent factor of cardiometabolic risk of cardiovascular diseases
Authors: Garbuzenko D. V. , Belov D. V.
Published: December 2021

Non-alcoholic fatty liver disease (NAFLD) is a pressing public health problem affecting up to a third of the world's adult population. The main reasons for its high mortality rate are cardiovascular diseases. They are caused by subclinical atherosclerosis characteristic of NAFLD, venous thromboembolic complications, functional and structural myocardial disorders, calcification of heart valves, heart rhythm and conduction disturbances. At the same time, NAFLD can serve as an independent factor of the cardiometabolic risk of their development, which is associated with atherogenic dyslipidemia, as well as the release of numerous pro-inflammatory mediators both from the pathologically altered liver and as a result of systemic endotoxemia, which is the result of disturbance of the intestinal microbiota, accompanied by a decrease in intestinal microbial gene richness., a change in its composition and function, followed by bacterial translocation. Considering that most patients with NAFLD die from cardiovascular complications, it becomes obvious that exclusively “liver-oriented” principles of their treatment cannot be sufficient, but require a multidisciplinary team approach involving cardiologists, cardiac surgeons and doctors of other related specialties.
The effect of non-alcoholic fatty liver disease on the functional state of the kidneys in patients with chronic heart failure
Authors: Statsenko M. E. , Turkina S. V. , Fabritskaya S. V. , Shilina N. N. , Titarenko M. N. , Kosivcova M. A. , Ryndina Yu. A. , Radzabova A. A.
Published: December 2021

Aim: to study the functional state of the kidneys in patients with chronic heart failure (CHF) and non-alcoholic fatty liver disease (NAFLD).

Materials and methods. 144 patients with CHF aged 45-70 years were divided into two groups: group 1 — persons with CHF and NAFLD, group 2 — CHF without NAFLD. A clinical examination was performed, the indices of FLI steatosis and NFS liver fibrosis were calculated, the functional state of the kidneys and the adipokine status were evaluated.

Results. The main group of patients with CHF and NAFLD is mainly represented by people with grade I obesity (73 (84%) vs 5 (9%), p<0.05). Among patients with CHF and NAFLD, a clinically significant decrease in GFR<60 ml/min/1.73 m2 was significantly more often detected compared to patients with CHF without NAFLD (37% vs 21% in groups 1 and 2, respectively). The level of albuminuria was significantly higher in the group of patients with CHF and NAFLD (200.7±22.3 [54.7;390] vs 92.6±23.4 [10.2;188.7] mg/g in groups 1 and 2, respectively). The percentage of individuals with an AU/CR. urine ratio >30 mg/g was statistically significantly higher in group 1 compared to group 2 (82.1 vs 51.1% in groups 1 and 2, respectively). The level of serum leptin was significantly higher and the concentration of serum adiponectin was significantly lower compared to group 2 in the main group of patients with CHF and NAFLD compared to the control group. There was a significantly higher occurrence of insulin resistance in patients with CHF and NAFLD. Correlation analysis revealed the presence of statistically significant associations between the parameters characterizing the functional state of the kidneys and the indices of FLI, NFD, adipokines, and the severity of insulin resistance.

Conclusion. In patients with CHF and NAFLD, a significant deterioration in the functional state of the kidneys was found, in comparison with patients with “isolated” CHF with comparable FC.
The value of the triglyceride-glucose index in the diagnosis of insulin resistance in early forms of non-alcoholic fatty liver disease
Authors: Shipovskaya A. A. , Larina N. A. , Kurbatova I. V. , Dudanova O. P.
Published: December 2021

The goal. To determine the value of the triglyceride glucose index (TGI) for the diagnosis of insulin resistance (IR) in early forms of non-alcoholic fatty liver disease (NAFLD).

Materials and methods. 99 patients with NAFLD were examined: 38 (38.4%) with liver steatosis (LS) and 61 (61.6%) with steatohepatitis (SH). TGI was determined by the formula — In [fasting TG (mg / dl) × fasting glucose (mg / dl) / 2], patients with LS and SH were divided into quartiles (Q1-Q4) by increasing TGI levels with an assessment of liver tests, insulin levels (“Insulin TEST System”, Monobind Inc., USA), HOMA-IR, fragments of cytokeratin-18 (FCK-18) ("TPS ELISA, Biotech”, Sweden) and TNF-α (“Human TNFα Platinum” ELISA, eBioscience, Austria).

Results. In patients with LS with a TGI increase from Q1 to Q4, HOMA-IR increased from 1.12 ± 0.48 to 6.02 ± 3.15 (p <0.05), a direct relationship was found between these indicators — r = 0.52 (p = 0.03). TGI also correlated with waist circumference — r = 0.81 (p = 0.01), cholesterol — r = 0.51 (p = 0.002), alkaline phosphatase — r = 0.41 (p = 0.02). In patients with SH, from Q1 to Q4, HOMA-IR increased from 3.15 ± 1.8 to 6.2 ± 3.04 (p <0.05), but there was no significant correlation between HOMA-IR and TGI. The levels of FCK-18 increased from Q1 to Q4-139.82 ± 72.45 to 359.75 ± 189.03 U / L (p <0.05) and TNF-α — from 6.38 ± 1.25 pg / ml up to 7.75 ± 1.09 pg / ml (p <0.05). There was a connection between TGI and the level of a marker of hepatocyte apoptosis — FCK-18 — r = 0.43 (p = 0.004).

Conclusion. In liver steatosis, TGI has demonstrated its diagnostic role as a surrogate marker of insulin resistance, correlating with HOMA-IR. In steatohepatitis, TGI reflected the degree of hepatocytic apoptosis, correlating with fragments of cytokeratin-18.
Comorbidity: non-alcoholic fatty liver disease and psoriasis
Authors: Nemchaninova O. B. , Sklyanova E. Yu. , Lykova S. G. , Makhnovets E. N. , Pozdnyakova O. N. , Reshetnikova T. B. , Khryanin A. A.
Published: December 2021

Non-alcoholic fatty liver disease (NAFLD), being a marker of significant changes in the hepatobiliary system against the background of metabolic syndrome and other endocrine pathologies, has a significant impact on the course of psoriatic disease. The presence of common mechanisms in the pathogenesis of these diseases suggests a very close relationship between them. This requires a multidisciplinary approach to studying the mechanisms of the pathogenesis of psoriasis and NAFLD, which will improve the methods of diagnosis and treatment of both diseases.
The role of hepatocellular death and systemic inflammation in the development of acute kidney injury in acute decompensation of alcoholic liver cirrhosis
Authors: Rodina A. S. , Shubina M. E. , Kurbatova I. V. , Topchieva L. V. , Dudanova O. P.
Published: December 2021

The aim of the study was to assess the role of hepatocellular death and systemic inflammation in the development of acute kidney injury (AKI) in acute decompensation of alcoholic liver cirrhosis (AD ALC).

Materials and methods. 125 patients with ALC were examined: 20 (16.0%) (group I) with signs of hepatorenal syndromeacute kidney injury (HRS-AKI) at the age of 57.13 ± 9,08 years, 13 men (65.0%) and 105 (84.0%) patients (group II) without such a syndrome at the age of 56.30 ± 9.6 years., 62 men (59.0%). Along with liver tests, a markers of hepatocyte apoptosis and cytokines were determined by ELISA: fragments of cytokeratin-18 (FCK-18) ("Biotech" Sweden), cytokines — TNF-α, IL-1β, IL-4, IL-6, IL-8 (“Vector-Best”, Russia). Grade and index of acute on chronic liver failure (ACLF) were determined using an on-line calculator (www.efclif.com/scientific-activity/score-calculators/clif-c-aclf).

Results. The hepatocellular death indicators were significantly higher in patients of group I with HRS-AKI compared with patients of group II without HRS-AKI: FCK-18-1609.44 ± 542.79 U / l versus 975.77±607.59 U / l, bilirubin — 242.64 ± 98.14 pmol/l versus 145.09 ± 79.35 pmol/l, inflammation indicators — TNF-α — 9.28 ± 3,11 pg/ml versus 6.59 ± 2.21 pg/ml, IL-6-54.79 ± 17.7 pg/ml versus 36.71 ± 18.05 pg/ml, CRP — 49.68 ± 23.23 mg/l versus 22.07 ± 20.40 mg/l, leukocytes — 12.23 ± 3.28x109/l versus 8,66 ± 2,31x109/l (everywhere p <0.05). ACLF developed in all (100.0%) patients of group I, its grade was 2.73±0.76 and score — 56.33 ± 4.01; ACLF developed only in 37 (35,2%) patients of group II, its grade was1.05±0.24 (p<0,05) and score was 47.45 ± 4,80 (p <0.05).

Conclusion. The development of HRS-AKI in patients with acute decompensation of ALC was associated with significantly higher rates of hepatocytic apoptosis, hyperbilirubinemia, systemic inflammation, frequency and severity of ACLF.
Recognizing and Implementing International Human Rights Standards in Domestic Legislation: An Exposure Under Ukrainian Law
Authors: Serohin Vitalii Oleksandrovych , Serohina Svitlana Hryhorivna , Gryshko Liliya Mykolayivna , Danicheva Kateryna Petrivna
Published: December 2021

Everything about human right is inalienable void of violation from the human race. It is therefore that responsibility of the international community in ensuring the effective preservation and respect of these rights without any threat of violations. In ensuring its recognition and implementation, international standards have been established where there is the need of States parties to these international human right treaties in ensuring its incorporation in its various domestic legislations. The content and specific features of the introduction of international human rights standards into national legislation have been analyzed in the article. The methodological basis of research is a set of general scientific and special methods, in particular, dialectical, historical-legal, epistemological, comparative-legal. International standards for the protection of human rights have been defined as principles and norms enshrined in international regulatory legal acts that define fundamental human rights and freedoms, the obligation of the State to respect them, to assist in their realization, preservation and protection against unlawful encroachments, and to establish liability for their violations and methods of protection. It has been clarified that the procedure of implementation of international human rights standards into national legislation includes the following stages: (i) recognition of human rights by the State and their enshrinement in national legislation; (ii) institutionalization of the standard of human rights protection; (iii) bringing the current legislation in line with the international human rights standard and interpreting the latter; (iv) establishment of measures and means of protection and defense of human rights; (v) determining the procedure for the realization of the enshrined right; (vi) control over the observance of the international human rights standard.
ANTIVIRAL ACTIVITY OF AMINOCAPROIC ACID AGAINST INFECTIOUS BRONCHITIS CORONAVIRUS IN VITRO
Authors: Dziublyk I. V. , Trokhimenko O. P. , Soloviov S. O. , Gumeniuk G. L. , Dziublyk O. Ya. , Gumeniuk N. I. , Yakovenko O. K.
Published: December 2021

I. V. Dziublyk, O. P. Trokhimenko, S. O. Soloviov, G. L. Gumeniuk, O. Ya. Dziublyk, N. I. Gumeniuk, O. K. Yakovenko Abstract The aim of the study is a preclinical evaluation of the antiviral activity of aminocaproic acid (ACA) against the prototype strain IBV (Infectious bronchitis virus) of Coronavirus family in vitro. Material and methods. During the research, modern methods were used to determine the cytotoxic effect of the evaluation on a monolayer of BHK-21 cell culture in vitro; cultivation, accumulation and determination of the infectious titer of IBV by cytopathic action on a monolayer of cell cultures; assessment of the antiviral effect of the drug — the establishment of the inhibitory concentration and the chemotherapeutic index (CTI) of ACA in various modes of drug administration: 2 hours before infection, simultaneously with infection and 2 hours after infection. Results. With the introduction of ACA 2 hours before infection, a decrease in the infectious titer of the IBV virus was not established. The antiviral activity of ACA was detected when the drug was added in 2 modes: simultaneously and 2 hours after infection. The introduction of ACА into the medium for cell cultivation at non-toxic concentrations of 7.91–15.82 mg / ml led to a decrease in the infectious titer of the virus by 1.4–2.0 lg TCD50 / 0.1 ml. The CTI of the ACA was 6 in the indicated concentrations and modes, which is an indicator of its promising potential for further studies of antiviral activity in vivo, including clinical studies. Conclusions. The direct antiviral effect of ACA against the prototype H-120 virus strain from the Coronaviridae family in vitro was revealed. The suppression of viral reproduction with an established low toxicity of the drug, a decrease in the infectious titer of IBV by 1.4–2.0 lg TCD50 / 0.1 ml and with a CTD equal to 6.0, indicate the prospects for further study of the antiviral properties of ACA in clinical trials. Key words: aminocaproic acid, coronavirus, antiviral activity.
PECULIARITIES OF CLINICAL MANAGEMENT OF ASTHMA DURING CORONAVIRUS DISEASE (COVID-19) PANDEMIC
Authors: Konopkina L. I.
Published: December 2021

PECULIARITIES OF CLINICAL MANAGEMENT OF ASTHMA DURING CORONAVIRUS DISEASE (COVID-19) PANDEMIC L. I. Konopkina Abstract The review is dedicated to the problem of interrelations between asthma (A), COVID-19 and inhaled corticosteroid (ICS) therapy. According to Global Initiative for Asthma (GINA) long-term treatment with systemic corticosteroids may lead to significant immunosuppression. Potentially, this is associated with higher risk of incidence and severity of viral infections. That was the reason why WHO in the beginning of 2020 had not granted recommendation for using systemic corticosteroids in COVID-19 patients if not indicated for other causes (including A and COPD exacerbations, usually requiring short course of oral corticosteroids). In Spring 2021 GINA renewed its recommendations on COVID-19 in A patients considering the grade of A symptoms control. It was demonstrated that patients with well-controlled A (mild to moderate) were neither at higher risk of COVID-19 occurrence nor of its more severe course. The risk of death from COVID-19 was also not increased in patients with well-controlled A. Moreover, in A patients 50 years of age and older, regularly taking ICS and admitted to hospital due to COVID-19, the mortality rate was lower than in other hospitalized patients. Today, it is important to debate whether ICS may interfere with the possibility of getting infected by coronavirus. It is well known that budesonide is one of most often prescribed ICS molecule. Budesonide in vitro has demonstrated a potential antiviral effect against different types of SARS-CoV-2. There are several ongoing studies in vivo: NCT04416399 (Great Britain; completed), NCT04355637 (Spain), NCT04193878, NCT04377711 (USA), NCT04331470 (Iran), NCT04330 (South Korea). The results of STOIC study, organized and conducted by Oxford university scientists, are of special interest. It was demonstrated that outpatient use of budesonide in COVID-19 patients reduced the risk of hospitalization and emergency care utilization by 90 %. There was a statistically significant reduction in symptoms intensity and time to clinical cure. Interim results of PRINCIPLE study suggested that early treatment with inhaled budesonide shortetens recovery time by a median of three days (comparing with usual care). In Budesonide Turbohaler group 32 % patients reached sustain recovery within 14 days of randomization (comparing with 22 % of patients in usual care group). Conclusion. Despite interim character of presented clinical trials data in this review, use of inhaled budesonide in COVID-19 patients, from our point of view, may be considered in particular clinical cases after a obligatory discussion with the patient.
OJK dan Sistem Moneter Indonesia
Authors: Yazid Sitti Amani
Published: December 2021

Dalam rangka memenuhi tugas matakuliah Ekonomi Moneter Islam, kami dari kelompok 7 akan membahas mengenai “OJK dan Sistem Moneter Indonesia”. Sistem keuangan merupakan suatu hal yang sangat penting dan memiliki peran yang prinsipil dalam perekonomian dan kehidupan. Sistem keuangan sendiri merupakan tatanan perekonomian dalam suatu negara yang berperan dan melakukan aktivitas dalam berbagai jasa keuangan yang dilakukan oleh lembaga keuangan, yang memiliki tugas dan fungsi utama adalah menyalurkan dana.Oleh sebab itu, suatu perekonomian harus memiliki kestabilan sistem keuangan dalam pengalihan dana tersebut agar berjalan dengan baik sehingga perekonomian dapat tumbuh dan meningkatkan standar kehidupan, karena dengan tidak stabilnya sistem keuangan akan berdampak pada menurunnya perekonomian bahkan dapat menyebabkan terjadinya krisis. Oleh karena itu, diperlukan adanya lembaga keuangan yang berperan sebagai lembaga intermediasi keuangan dan menjalankan sistem keuangan.
Pamali untuk Restorasi Ekosistem
Authors: Cahyana Gede H
Published: December 2021

Restorasi Ekosistem (Ecosystem Restoration) adalah tema peringatan Hari Lingkungan Sedunia 5 Juni 2021. Ekosistem adalah sistem ekologi, yaitu hubungan timbal balik antara makhluk hidup dengan makhluk hidup lainnya dan dengan makhluk tak hidup (abiotik). Restorasi memiliki makna pemulihan, perbaikan, menjadikan seperti sedia kala. Restorasi ekosistem adalah upaya memulihkan kerusakan tempat hidup tumbuhan, hewan, manusia dan saling kebergantungannya menjadi lebih baik (seperti semula).
Analisis Laporan Keuangan
Authors: K Khelvin.
Published: December 2021

Pihak-pihak yang memiliki kepentingan terhadap perkembangan suatu perusahaan sangatlah perlu untuk mengetahui kondisi keuangan suatu perusahaan. Laporan keuangan yaitu suatu media informasi yang digunakan oleh suatu perusahaan untuk melaporkan keadaan dan posisi keuangan perusahaan kepada pihak-pihak yang berkepentingan yaitu pihak internal dan eksternal perusahaan yang bermanfaat bagi pihak tersebut dalam pengambilan keputusan secara ekonomi.
PEMBELAJARAN DASAR-DASAR ALGORITMA DAN PEMROGRAMAN
Authors: Mulyani Rizky
Published: December 2021

Algoritma ialah suatu langkah-langkah yang tersusun dalam menyelesaikan sebuah permasalahan yang disusun secara runut dan tersusun. Algoritma adalah langkah-langkah komputasi yang terartikan dengan baik dengan menggunakan beberapa nilai untuk input dan menciptakan beberapa nilai yang dikenal dengan keluaran. Jadi, algoritma ialah urutan langkah-langkah komputasi yang mengubah data masukan menjadi keluaran. Dalam konsep dasar algoritma pemograman ini,mudah bagi orang untuk mulai belajar algoritma pemograman.Karena seseorang akan lebih dulu mengetahui apa-apa saja hal-hal dasar dalam konsep dasar algoritma yang terdapat dalam algoritma pemograman.
Tone Probe Paradigm (the dot probe paradigm's forgotten ancestry)
Authors: Halkiopoulos Christos
Published: December 2021

This is my BSc dissertation completed at, and submitted to, UCL's Psychology Department in 1981. It reports on my attentional probe paradigm initially used by myself in the auditory modality to demonstrate attentional biases in the processing of threatening information by participants with identifiable personality characteristics. A group of researchers at St. George's (University of London), introduced to this paradigm by M. W Eysenck, applied my attentional probe paradigm in the visual modality (dot probe paradigm). This dissertation is hand-written, rather hurriedly put together, but still easy to read. The experimental work which introduced the attentional probe paradigm appears towards the end of the dissertation.
Manajemen Sumber Daya Manusia
Authors: Jannah Miftahul
Published: December 2021

Sumber daya manusia sebagai salah satu sumber daya yang ada dalam organisasi memegang peranan yang penting dalam keberhasilan pencapaian tujuan organisasi. Sumber daya manusia menggunakan sumber daya lain yang dimiliki oleh organisasi dalam rangka mencapai tujuan. Mesin-mesin berteknologi canggih sekalipun tidak akan ada artinya, jika sumber daya manusia yang menjalankannya tidak berkualifikasi untuk mengerjakannya. Demikian juga dengan sumber dayainformasi. Sebaik dan selengkap apa pun informasi yang diterima oleh organisasi, tidak akan berarti apa-apa, jika kualitas sumber daya manusia yang ada tidak mampu menerjemahkannya menjadi informasi yangberguna bagi perkembangan dan kemajuan organisasi.
Tugas Makalah Kelompok 13 SISKOM "Komunikasi Melalui Teknologi dan Media Sosial"
Authors: Nurhayati  , Annisa Nurul , Ap Fitriani putri
Published: December 2021

Teknologi komunikasi adalah suatu sistem yang dilakukan oleh masyarakat modern untuk saling berhubungan satu dengan yang lain untuk melakukan pertukaran pesan lewat panca indera sebagaimana fungsi komunikasi dalam manajemen logistik. Sedangkan Media sosial adalah platform digital yang memfasilitasi penggunanya untuk saling bersosial, baik itu berkomunikasi atau membagikan konten berupa tulisan, foto dan video. Segala konten yang dibagikan tersebut akan terbuka untuk publik secara realtime. Media sosial adalah fenomena populer yang menarik banyak perhatian.
ECONOMIC VALUATION OF MANGROVE FOREST IN TONGAS DISTRICT, PROBOLINGGO REGENCY, EAST JAVA
Authors: Idzatilangi Wening Ila , Pasau Charistoper Romeo
Published: December 2021

It is a literature review study and was undertaken from 1 December to 15 December 2021. This research aims to identifying the economic value of mangrove forest in Tongas District, Problonggo Regency, East Java. The object being researched was the mangrove forest in Tongas District. The study conducted by objectifying mangrove wood as furniture and other materials, while the mangrove ecosystem is a place to maintain the hydrological cycle and quality, as well as a tourist attraction. The economic valuation will be given from the prices in the marketplaces including the online one. The result of this research showed that the yearly benefits of the ecosystem of mangrove area at Tongas District can be grouped into: (1) direct benefit of IDR 6.638.421; (2) indirect benefits of IDR 3.651.710.094.700; and (3) optional benefits of IDR 325.000. With the total value is IDR. 3.651.717.058.121 per year. With indirect values occupy the highest. So, it can be said, if the role of Mangrove forests as environmental providers is very high. It indicates if there is high need to protect the forest.
KOMUNIKASI BISNIS PADA PERUSAHAAN UMUM DAN PERUSAHAAN SYARIAH
Authors: Ali Annisya Wahdania , Putri Miyati Diana , Rafly Andi
Published: December 2021

Komunikasi diperlukan dalam berbagai bidang kehidupan manusia, salah satunya adalah di sektor ekonomi yaitu bisnis maupun disebuah perusahaan. Melihat kondisi ekonomi di bidang bisnis yang serba kompetitif terutama di era globalisasi, pengusaha bisnis diharapkan dapat menempatkan dan mempertahankan posisinya diantara berbagai persaingan. Pengusaha bisnis yang tidak dapat mempertahankan posisinya di masyarakat, akan kalah bersaing dan jatuh dalam waktu cepat atau lambat. Sejalan dengan semakin pesatnya pertumbuhan dan perubahan ekonomi dan kegiatan bisnis yang berjalan, pengusaha membutuhkan strategi dan konsep komunikasi yang tepat dalam menjaga keberlangsungan hidup dari usahanya, terutama dalam mencapai tujuan yang diinginkan yaitu untuk mendapatkan konsumen agar usahanya tetap berjalan. Hal ini seperti yang diungkapkan oleh Purwanto (2011: 5) yaitu komunikasi bisnis merupakan komunikasi yang digunakan dalam dunia bisnis yang mencakup berbagai macam bentuk komunikasi, baik komunikasi verbal maupun nonverbal untuk mencapai tujuan tertentu.Perkembangan bisnis yang begitu pesat mempengaruhi perkembangan komunikasi yang cukup signifikan, salah satunya adalah komunikasi bisnis. Komunikasi memegang peranan penting dalam keberhasilan suatu usaha atau perusahaan. Dalam kegiatan komunikasi bisnis, pesan hendaknya tidak hanya sekedar informatif, yaitu agar pihak lain mengerti dan tahu, tetapi juga haruslah Persuasif, agar pihak lain bersedia menerima suatu paham atau keyakinan atau melakukan suatu perbuatan atau kegiatan.Dengan melakukan komunikasi bisnis, seseorang dapat meraih keuntungan dengan meningkatkan jualannya. Tanpa komunikasi, maka produk yang dijual tidak akan dikenal oleh konsumen. Komunikasi dilakukan baik- secara langsung maupun melalui media promosi untuk meningkatkan keuntungan.
Menerapkan Pembelajaran Campuran dalam Kursus Algoritma dan Pemrograman Untuk Meningkatkan Kemandirian Siswa
Authors: Ginting Selly Madela Br
Published: December 2021

Pelajaran ini akan menunjukkan kepada Anda cara menggunakan Google Classroom untuk menerapkan pembelajaran campuran dan meningkatkan kemandirian siswa. Metode survei dengan deskripsi kuantitatif. Partisipan dalam penelitian ini berjumlah 126 mahasiswa semester ganjil tahun 2020. Peralatan penelitian menggunakan angket skala likert. Dengan menerapkan blended learning berdasarkan hasil penelitian ini, siswa dapat belajar lebih mandiri. Hasil untuk masing-masing indikator meliputi independensi 81,23% dan keyakinan 74,98%. 80, 41% perilaku disiplin, 79,52% tanggung jawab. Perilaku terjadi secara spontan pada 80% dan 76%.Latihan 79,72% pengendalian diri. Berdasarkan hasil tersebut, blended learning berpotensi menjadi alternatif pendidikan yang cocok untuk meningkatkan kemandirian belajar siswa.
Hikmah Covid-19 Bagi Literasi
Authors: Cahyana Gede H
Published: December 2021

Virus Corona baru (novel Coronavirus) penyebab wabah Covid-19 mengubah kehidupan manusia. Belajar, bekerja, bersekolah, beribadah, berdagang, bersikap dan berperilaku juga berubah. Muncul gaya hidup baru. Gaya hidup baru ini berlaku minimal selama pandemik atau selama vaksinnya belum ditemukan. Hingga akhir September 2020 belum bisa dipastikan oleh ahlinya kapan vaksin Covid-19 dinyatakan siap diberikan kepada manusia. Sambil menunggu kehadiran vaksin tersebut tentu semua aktivitas hidup manusia harus terus berlangsung tetapi dengan perubahan. Dunia pendidikan misalnya, sudah berubah. Murid dan mahasiswa disuruh belajar di rumah masing-masing. Begitu juga guru dan dosen disuruh mengajar dari rumah. Hanya dalam kasus khusus saja guru dan murid boleh bertemu di sekolah dan wajib melaksanakan protokol baku kesehatan untuk Covid-19. Ada positifnya, yaitu guru, dosen, murid, dan mahasiswa menjadi makin akrab dengan internet. Akrab dengan e-mail, WA, Telegram, Zoom, Google Meet, Youtube, website, dan blog. Murid dan mahasiswa mengerjakan tugas dari guru dan dosen dengan bantuan platform media komunikasi dunia maya tersebut.
The COVID States Project #75: Attitudes toward COVID-19 boosters before and after Omicron
Authors: Perlis Roy , Baum Matthew , Trujillo Kristin Lunz , Lazer David , Safarpour Alauna , Druckman James , Ognyanova Katherine , Santillana Mauricio , Quintana Alexi , Uslu Ata , Green Jon , Pippert Caroline H , Lin Jennifer , Shere Anjuli , Qu Hong
Published: December 2021

Recognizing that the protection conferred by COVID-19 vaccines may wane over time, the US Centers for Disease Control and Prevention (CDC) has encouraged adults in the United States to receive booster shots that can augment their immunity to the virus. While the Biden administration sought to encourage all adults to receive boosters, the CDC initially authorized the shots only for higher-risk individuals. Subsequently, authorization was broadened to all adults, although only higher-risk individuals were encouraged to pursue boosters. Most recently, after substantial criticism, the CDC changed its language to encourage all adults to receive boosters.But regardless of the language, are US adults sufficiently convinced to seek booster shots? Will the same factors that contributed to COVID-19 vaccine hesitancy and vaccine resistance impact booster shots? The answers may have profound public health implications as the US enters the season during which respiratory viruses typically have the greatest impact, and the highly-transmissible Omicron variant rapidly becomes the dominant form of COVID-19, after being labeled a variant of concern by the World Health Organization on November 26th.Between November 3rd and December 3rd, 2021, the COVID States Project asked 22,277 adults in all 50 US states and the District of Columbia about their attitudes and behaviors regarding COVID-19. In particular, we asked about whether people are vaccinated or intend to be vaccinated, and whether they had sought booster shots or intend to seek a booster shot. In this brief report, we examine attitudes toward COVID-19 booster shots, and whether they differ across particular groups of people. Since the survey was ongoing when news about Omicron emerged in the US, we also take an initial look at whether these attitudes have begun to shift along with perceptions of the threat posed by COVID-19 subsequent to the November 26th announcement.
Pressure sensor chip utilizing electrical circuit of piezosensitive differential amplifier with negative feedback loop (PDA-NFL) for 5 kPa
Authors: Mikhail
Published: December 2021

High sensitive (S = 11.2 ± 1.8 mV/V/kPa with nonlinearity error 2KNL = 0.15 ± 0.09%/FS) small-sized (4.00x4.00 mm2) silicon pressure sensor chip utilizing new electrical circuit for microelectromechanical systems (MEMS) in the form of differential amplifier with negative feedback loop (PDA-NFL) for 5 kPa differential was developed. The advantages are demonstrated in the array of output characteristics, which prove the relevance of the presented development, relative to modern developments of pressure sensors with Wheatstone bridge electrical circuit for 5 kPa range.
Religiusitas dan Kepercayaan Dalam Hukum Adat Lontara
Authors: SUSASTRA ANDI ANDRA
Published: December 2021

Sistem kepercayaan dimaksudkan adalah bayangan manusia terhadap berbagai perwujudan yang berada di luar jangkauan akal dan pikiran manusia, keberagamaan dan kepercayaan orang Bugis-Makassar yang identik dengan Islam masih sarat dengan praktik sinkretisme antara ajaran Islam dan pra-Islam.
Fiscal policies to promote environmentally sustainable food production and consumption: A scoping review protocol
Authors: Bell Brooke Marie , Nyhan Kate , Dubrow Robert , Bell Michelle , Irwin Melinda L. , Ferrucci Leah M.
Published: December 2021

The objective of this scoping review is to examine food taxes and subsidies and their environmental outcomes by incorporating evidence from the peer-reviewed literature and evidence from the non-peer-reviewed or ‘grey’ literature, including policy documents/briefs, research reports, and white papers. The scoping review questions are:1. What food taxes and subsidies have been studied in the context of environmentally sustainable food production or consumption?2. What types of environmental outcomes were reported?3. At what various levels (e.g., food production-, food outlet-, consumer-level) were the policies implemented?This is the final version of the scoping review protocol, published as a preprint to create full transparency about the scoping review process.
E-CRM E business
Authors: Beverly Louis
Published: December 2021

E crm e business 2101714585