bluuebunny/crossref_metadata_2025 huggingface dataset:
D2Former: Dual-Domain Transformer for Change Detection in VHR Remote Sensing Images
Authors: Zheng Huanhuan , Liu Hui , Lu Lei , Li Shiyin , Lin Jiyan
Published: June 2024

Computational intelligence technologies have been extensively applied for the interpretation of remote sensing imagery. Recently, the computational-intelligence-based Transformer change detection (CD) approach has attracted increasing attention. However, the current Transformer-based CD method can better capture global features, but there is no good solution for the loss of local detail information. For this reason, introducing semantic and frequency information from the perspective of a dual-domain can be beneficial for improving the representation of detailed features to improve CD performance. To overcome this limitation, a dual-domain Transformer (D2Former) is proposed for CD. Firstly, we adopt a semantic tokenizer to capture the semantic information, which promotes the enrichment and refinement of semantic change information in the Transformer. Secondly, a frequency tokenizer is introduced to acquire the frequency information of the features, which offers the proposed D2Former another aspect and dimension to enhance the ability to detect change information. Therefore, the proposed D2Former employs dual-domain tokenizers to acquire and fuse the feature representation with rich semantic and frequency information, which can refine the features to acquire more fine-grained CD ability. Extensive experiments on three CD benchmark datasets demonstrate that the proposed D2Former obviously outperforms some other existing approaches. The results present the competitive performance of our method on the WHU-CD, LEVIR-CD, and GZ-CD datasets, for which it achieved F1-Score metrics of 92.85%, 90.60%, and 87.02%, respectively.
SURE: Structure for Unambiguous Requirement Expression in Natural Language
Authors: Parrales-Bravo Franklin , Caicedo-Quiroz Rosangela , Barzola-Monteses Julio , Vasquez-Cevallos Leonel , Galarza-Soledispa María Isabel , Reyes-Wagnio Manuel
Published: June 2024

This study presents three structures for clearly expressing functional requirements (FRs) and quantitative non-functional requirements (qt-NFRs). Expressing requirements with these structures will allow the understanding of requirements by stakeholders and software developers. The first structure is the SURE format, which is composed of three main sections: a title, a short definition, and a detailed description. The second proposed structure is a template to facilitate the definition of the title and description of unambiguous FRs. It is based on the application of CRUD operations on a certain entity, calling it the “CRUDE” structure. Finally, the third structure serves as a template to make it easier to clearly define the description and title of qt-NFRs. It is based on the application of system properties to computer events or actions, calling it the “PROSE” structure. In this, it is very important to specify those metric values that are desired or expected by the stakeholder. To know how much the definition of FRs and qt-NFRs improved when the proposed structures were used, 46 requirement specification documents elaborated as homework by students of the “Requirement Engineering” course offered at the University of Guayaquil between 2020 and 2022 were evaluated by five experts with more than 10 years of experience in software development for Ecuadorian companies. The findings showed that students reduced the percentage of unambiguous FRs and qt-NFRs from over 80% to about 10%. In conclusion, the findings demonstrate how crucial the three structures proposed in this paper are to helping students develop the ability to clearly express requirements.
Hybrid State Estimation: Integrating Physics-Informed Neural Networks with Adaptive UKF for Dynamic Systems
Authors: de Curtò J. , de Zarzà I.
Published: June 2024

In this paper, we present a novel approach to state estimation in dynamic systems by combining Physics-Informed Neural Networks (PINNs) with an adaptive Unscented Kalman Filter (UKF). Recognizing the limitations of traditional state estimation methods, we refine the PINN architecture with hybrid loss functions and Monte Carlo Dropout for enhanced uncertainty estimation. The Unscented Kalman Filter is augmented with an adaptive noise covariance mechanism and incorporates model parameters into the state vector to improve adaptability. We further validate this hybrid framework by integrating the enhanced PINN with the UKF for a seamless state prediction pipeline, demonstrating significant improvements in accuracy and robustness. Our experimental results show a marked enhancement in state estimation fidelity for both position and velocity tracking, supported by uncertainty quantification via Bayesian inference and Monte Carlo Dropout. We further extend the simulation and present evaluations on a double pendulum system and state estimation on a quadcopter drone. This comprehensive solution is poised to advance the state-of-the-art in dynamic system estimation, providing unparalleled performance across control theory, machine learning, and numerical optimization domains.
Advancing Artificial Intelligence (AI) and Machine Learning (ML) Based Soft Sensors for In-Cylinder Predictions with a Real-Time Simulator and a Crank Angle Resolved Engine Model
Authors: Jane Robert , Rose Samantha , James Corey M.
Published: June 2024

In a previous research effort by this group, pseudo engine dynamometer data in multi-dimensional arrays were combined with dynamic equations to form a crank angle resolved engine model compatible with a real-time simulator. The combination of the real-time simulator and external targets enabled the development of a software-in-the-loop (SIL) environment that enabled near-real-time development of AI/ML and real-time deployment of the resulting AI/ML. Military applications, in particular, are unlikely to possess large quantities of non-sparse operational data that span the full operational range of the system, stove-piping the ability to develop and deploy AI/ML which is sufficient for near-real-time or real-time control. AI/ML has been shown to be well suited for predicting highly non-linear mathematical phenomena and thus military systems could potentially benefit from the development and deployment of AI/ML acting as soft sensors. Given the non-sparse nature of the data, it becomes exceedingly important that AI/ML be developed and deployed in near-real-time or real-time in parallel to a real-time system to overcome the inadequacy of applicable data. This research effort used parallel processing to reduce the training duration of the shallow artificial neural networks (SANN) and forest algorithms forming ensemble models. This research is novel in that the SIL environment enables pre-developed AI/ML to be adapted in near-real-time or develop AI/ML in response to changes within the operation of the applied system, different load torques, engine speeds, and atmospheric conditions to name a few. Over time it is expected that the continued adaptation of the algorithms will lead to the development of AI/ML that is suitable for real-time control and energy management.
Integrating Floating Photovoltaics with Hydroelectricity
Authors: Madeško Mirsad , Helać Vahid , Fejzić Ajdin , Konjicija Samim , Akšamović Abdulah , Grebović Selma
Published: June 2024

The transition process from fossil fuels to environmentally friendly renewable energy sources carries the risk of creating new environmental damages. Photovoltaic technology represents one of the alternatives with the least risk of harmful environmental impact. However, this technology has two important drawbacks: the significant land occupation for the installation of PV systems and the uncontrollability of production. By constructing floating photovoltaic plants on hydroelectric reservoirs, both of these problems can be reduced to an acceptable level. Some artificial reservoirs, originally built for hydroelectric power plants, have acquired a significant secondary function as recreational areas and fish breeding sites. Therefore, there is justified resistance from the local community to change the existing appearance and purpose of such reservoirs. This paper proposes a completely new concept of integrating the interests of the local community into such objects. In addition to preserving existing uses, the concept also offers new features. This can make the entire system environmentally friendly and sustainable. This paper details the technology behind the construction of floating photovoltaic power plants on artificial reservoirs and emphasizes their various advantages. These benefits include the non-utilization of cultivable land, the ease of assembly and construction, integration into existing power grids, and the potential to address electricity storage issues. For instance, Buško Lake, covering an area of 55.8 km2, may host 2.93 km2 of installed floating photovoltaic (FPV) facilities, enabling a total installed capacity of 240 MW. With an average of 5.5 h of daily sunshine, this totals 2007 annual hours, equivalent to a 55 MW thermal power plant. An analysis showed that, with losses of 18.2%, the average annual production stands at 302 GWh, translating to an annual production value of 18 million € at 60 €/MWh. The integration of this production into an existing hydroelectric power plant featuring an artificial reservoir might boost its output by 91%. The available transmission line capacity of 237 MW is shared between the hydroelectric power plant (HPP) and FPV; hence during the FPV maximum power generation time, the HPP halts its production. HPP Orlovac operates a small number of hours annually at full capacity (1489 h); therefore in combination with the FPV, this number can be increased to 2852 h. This integration maintains the lake’s functions in tourism and fishing while expanding its capabilities without environmental harm.
Development of the Polish Power Sector towards Energy Neutrality—The Scenario Approach
Authors: Gutowski Andrzej , Maciejczak Mariusz
Published: June 2024

This article discusses three scenarios for the transformation of the Polish power system leading to the achievement of climate neutrality through investment in renewable energy sources. The scenarios differ in terms of the role played by the selected energy technologies. The scenarios were developed using the balancing tool, the Simulator Polish Power System, which analyzed the development of the national power system in terms of optimal costs of achieving climate neutrality and the lowest possible price of electricity generation. The research shows that under Polish climatic conditions, 100% RES energy can be achieved in the balance, but ensuring the continuity of energy supply, which in future will be generated mainly from this type of source, requires the participation of controllable sources such as gas-fired power plants powered by biomethane and energy storage facilities. The scenarios assume balancing RES sources with 15–25 GW of available gas sources and 40 GWh in electricity storage. The article also discusses factors limiting the suggested scenarios, such as the availability of sustainable biomethane in Poland or limitations associated with the possibility of building onshore and offshore wind turbines.
The Trade-Off between Combustion and Partial Oxidation during Chemical Looping Conversion of Methane
Authors: Miccio Francesco , Mazzocchi Mauro , Boscherini Mattia , Storione Alba , Minelli Matteo , Doghieri Ferruccio
Published: June 2024

The chemical looping reforming and combustion of methane have attracted increasing interest as processes for clean energy and syngas production, with potential to reduce carbon dioxide emissions. Previous literature on the development of oxygen carriers evidenced the effects that oxygen availability exerts on the selectivity of the oxidation reaction. In the present paper, we evaluate the performance of chromite sand (Chro), cerium dioxide (CeO2), and mixed cerium–copper oxide (Ce–Cu) as oxygen carriers for either reforming or combustion according to their oxygen availability. The oxides are tested in 2 to 5 min reduction intervals in a CH4/N2 mixture (5, 10 and 20% vol.) followed by regeneration in O2/N2 (3, 5, or 21% vol.), with redox cycles conducted either at 850 °C or 950 °C. The obtained rank of selectivity towards complete CH4 combustion is Ce–Cu > CeO2 > Chro. Another relevant finding is the role of the degree of carrier conversion in promoting partial or total oxidation. In particular, the selectivity towards CO2 markedly decreases at increasing carrier conversion, disclosing new strategies for process design and optimization by controlling the carrier conversion degree.
Economic Optimal Scheduling of Integrated Energy System Considering Wind–Solar Uncertainty and Power to Gas and Carbon Capture and Storage
Authors: Zhang Yunlong , Zhang Panhong , Du Sheng , Dong Hanlin
Published: June 2024

With the shortage of fossil energy and the increasingly serious environmental problems, renewable energy based on wind and solar power generation has been gradually developed. For the problem of wind power uncertainty and the low-carbon economic optimization problem of an integrated energy system with power to gas (P2G) and carbon capture and storage (CCS), this paper proposes an economic optimization scheduling strategy of an integrated energy system considering wind power uncertainty and P2G-CCS technology. Firstly, the mathematical model of the park integrated energy system with P2G-CCS technology is established. Secondly, to address the wind power uncertainty problem, Latin hypercube sampling (LHS) is used to generate a large number of wind power scenarios, and the fast antecedent elimination technique is used to reduce the scenarios. Then, to establish a mixed integer linear programming model, the branch and bound algorithm is employed to develop an economic optimal scheduling model with the lowest operating cost of the system as the optimization objective, taking into account the ladder-type carbon trading mechanism, and the sensitivity of the scale parameters of P2G-CCS construction is analyzed. Finally, the scheduling scheme is introduced into a typical industrial park model for simulation. The simulation result shows that the consideration of the wind uncertainty problem can further reduce the system’s operating cost, and the introduction of P2G-CCS can effectively help the park’s integrated energy system to reduce carbon emissions and solve the problem of wind and solar power consumption. Moreover, it can more effectively reduce the system’s operating costs and improve the economic benefits of the park.
Energy Storage Improves Power Plant Flexibility and Economic Performance
Authors: Sarunac Nenad , Khalesi Javad , Khuda Mahfuja A. , Mancini Rick , Kulkarni Pramod , Berger Joel
Published: June 2024

Most existing coal-fired power plants were designed for sustained operation at full load to maximize efficiency, reliability, and revenue, as well as to operate air pollution control devices at design conditions. Depending on plant type and design, these plants can adjust output within a fixed range in response to plant operating or market conditions. The need for flexibility driven by increased penetration of variable and non-dispatchable power generation, such as wind and solar, is shifting the traditional mission profile of thermoelectric power plants in three ways: more frequent shutdowns when market or grid conditions warrant, more aggressive load ramp rates (rate of output change), and a lower minimum sustainable load, which provides a wider operating range and helps avoid costly plant shutdowns. Recent studies have shown that the flexibility of a coal-fired power plant can be improved by energy storage. The objective of this work was to analyze a set of energy storage options and determine their impact on the flexibility and economics of a representative coal-fired power plant. The effect of three energy storage systems integrated with a coal power plant on plant flexibility and economics was investigated. The results obtained in this project show that energy storage systems integrated with a thermal power plant improve plant flexibility and participation in the energy and ancillary services markets, which improves plant financial performance. The study was funded by the U.S. Department Office of Fossil Energy FE-1 under award number DE-FE0031903.
Autochthonous Conifers of Family Pinaceae in Europe: Broad Review of Morpho-Anatomical and Phytochemical Properties of Needles and Genetic Investigations
Authors: Nikolić Biljana M. , Ballian Dalibor , Mitić Zorica S.
Published: June 2024

Gymnosperms are a very old and small group of plants compared to angiosperms. Contemporary science recognizes about 650 extant conifers worldwide. This review focuses on species of the Pinaceae family found in Europe. There are 23 species from the genera Abies, Larix, Picea, and Pinus. Some of them are widespread in Europe, but others have fragmented and limited distribution and are classified as relic, endemic, or endangered. The aim of this review is providing cumulative information about the variability of needle morpho-anatomy, terpenes, and n-alkanes, as well as the genetics of the Pinaceae species, native to Europe. The first morpho-anatomical examinations of needles were conducted in the 19th century. A lot of species have been investigated up to now, but the population variability of many conifer species is still not known. The composition and abundance of terpenes differ between genera and families but also within the same genus, pointing to their taxonomic importance. n-Alkanes on the needle wax surfaces of conifers are sometimes very useful markers of species and population variability. The most abundant n-alkanes in Abies species are nonacosane (C29), hentriacontane (C31), or heptacosane (C27), whereas in Larix decidua and the majority of Picea species, C31 is predominant. C31 and C29 are the dominant n-alkanes in the genus Pinus. The most extensive population-genetic studies of European representatives of the Pinaceae family have focused on Abies alba, Picea abies, Pinus nigra, and Pinus sylvestris, but also examined endemic species such as Abies borisii-regis, A. cephalonica, A. nebrodensis, and Picea omorika. These studies hold significant practical value in assessing species’ evolutionary potential, devising strategies for long-term species conservation, identifying centers of diversity, detecting relict and ancestral populations, unveiling cryptic species and hybrids, and elucidating the taxonomic significance of species. These investigations are of great value not only on the biodiversity level, but also on the levels of ecology, physiology, taxonomy, and evolution.
Site-Level Modelling Comparison of Carbon Capture by Mixed-Species Forest and Woodland Reforestation in Australia
Authors: Kramer Koen , Bennett Lauren T. , Borelle Remi , Byrne Patrick , Dettman Paul , England Jacqueline R. , Heida Hielke , Galama Ysbrand , Haas Josephine , van der Heijden Marco , Pykoulas Anna , Keenan Rodney , Krishnan Vithya , Lindorff Helena , Paul Keryn I. , Nooijen Veronica , van Veen Jeroen , Versmissen Quinten , Asjes Arnout
Published: June 2024

Large areas of Australia’s natural woodlands have been cleared over the last two centuries, and remaining woodlands have experienced degradation from human interventions and anthropogenic climate change. Restoration of woodlands is thus of high priority both for government and society. Revegetation of deforested woodlands is increasingly funded by carbon markets, with accurate predictions of site-level carbon capture an essential step in the decision making to restore. We compared predictions of carbon in above-ground biomass using both the IPCC Tier 2 modelling approach and Australia’s carbon accounting model, FullCAM, to independent validation data from ground-based measurements. The IPCC Tier 2 approach, here referred to as the FastTrack model, was adjusted to simulate carbon capture by mixed-species forests for three planting configurations: direct seeding, tubestock planting, and a mix thereof. For model validation, we collected data on above-ground biomass, crown radius, and canopy cover covering an age range of 9–35 years from 20 plantings (n = 6044 trees). Across the three planting configurations, the FastTrack model showed a bias of 2.4 tC/ha (+4.2% of the observed mean AGB), whilst FullCAM had a bias of −24.6 tC/ha (−42.9% of the observed mean AGB). About two-thirds of the error was partitioned to unsystematic error in FastTrack and about one-quarter in FullCAM, depending on the goodness-of-fit metric assessed. Model bias differed strongly between planting configurations. For the FastTrack model, we found that additional canopy cover data estimated from satellite images obtained at different years can improve the carbon capture projections. To attain the highest accuracy of carbon projection at the site level, we recommend using a model with parameters calibrated for the specific planting configuration using local representative data.
Dual-Model GWAS Analysis and Genomic Selection of Maize Flowering Time-Related Traits
Authors: Fan Zehui , Lin Shaohang , Jiang Jiale , Zeng Yukang , Meng Yao , Ren Jiaojiao , Wu Penghao
Published: June 2024

An appropriate flowering period is an important selection criterion in maize breeding. It plays a crucial role in the ecological adaptability of maize varieties. To explore the genetic basis of flowering time, GWAS and GS analyses were conducted using an associating panel consisting of 379 multi-parent DH lines. The DH population was phenotyped for days to tasseling (DTT), days to pollen-shedding (DTP), and days to silking (DTS) in different environments. The heritability was 82.75%, 86.09%, and 85.26% for DTT, DTP, and DTS, respectively. The GWAS analysis with the FarmCPU model identified 10 single-nucleotide polymorphisms (SNPs) distributed on chromosomes 3, 8, 9, and 10 that were significantly associated with flowering time-related traits. The GWAS analysis with the BLINK model identified seven SNPs distributed on chromosomes 1, 3, 8, 9, and 10 that were significantly associated with flowering time-related traits. Three SNPs 3_198946071, 9_146646966, and 9_152140631 showed a pleiotropic effect, indicating a significant genetic correlation between DTT, DTP, and DTS. A total of 24 candidate genes were detected. A relatively high prediction accuracy was achieved with 100 significantly associated SNPs detected from GWAS, and the optimal training population size was 70%. This study provides a better understanding of the genetic architecture of flowering time-related traits and provides an optimal strategy for GS.
Post-Fire Coleoptera Fauna in Central Russian Forests after the 2021 Fires (Study Using Beer Traps)
Authors: Egorov Leonid V. , Ruchin Alexander B. , Fayzulin Alexander I.
Published: June 2024

Fires can significantly impact forest ecosystems. However, studies on the effects of fires on insect communities in post-fire plots in natural forests are rare. This study presents an analysis of the Coleoptera fauna in the forests of the Mordovia State Nature Reserve (European Russia) in 2022 and 2023 after a fire. Insects were sampled from burned plots (9) in 2010 and 2021, as well as unburned (control) plots (2), and alpha diversity was compared. After processing the material, we examined a total of 12,218 Coleoptera specimens from 38 families and identified 194 species. The families Nitidulidae, Cerambycidae, Elateridae, and Scarabaeidae were the most abundant across all plots. Cerambycidae, Elateridae, Nitidulidae, Staphylinidae, Coccinellidae, and Scarabaeidae exhibited the greatest species diversity. In total, 17 species were found on all plots, including Cetonia aurata, Protaetia cuprea volhyniensis, Trogoderma glabrum, Carpophilus hemipterus, Epuraea biguttata, Glischrochilus grandis, Glischrochilus hortensis, Glischrochilus quadripunctatus, Soronia grisea, Pediacus depressus, Chrysanthia geniculata, Anastrangalia reyi, Leptura quadrifasciata, Leptura thoracica, Lepturalia nigripes, Rhagium mordax, and Anisandrus dispar. Only five species exhibited preferences for certain plots. Maximum abundance and species diversity were observed on unburned (control) plots. The plots where fires occurred in 2010 and 2021 had the lowest total abundance values for Coleoptera. These fires destroyed almost all potential sites for beetle settlement, feeding, breeding, and shelter. Traps recorded a higher abundance of Coleoptera in the first year after fires compared to the second year. The Coleoptera fauna showed the greatest similarity on the control plots.
The Role of Different Medical Therapies in the Management of Adenomyosis: A Systematic Review and Meta-Analysis
Authors: Galati Giulia , Ruggiero Gianfilippo , Grobberio Alice , Capri Oriana , Pietrangeli Daniela , Recine Nadia , Vignali Michele , Muzii Ludovico
Published: June 2024

Background/Objectives: Adenomyosis is a benign condition characterized by the presence of endometrial tissue within the myometrium. Despite surgery being a valuable approach, medical options are considered as the first-line approach and have been investigated in the treatment of adenomyosis, although strong evidence in favor of these is still lacking. This study aims to gather all available data and determine the effectiveness of the aforementioned medical options in patients with associated pain and not currently seeking pregnancy, both in comparison to placebo and to one another. Methods: For this study, PubMed and EMBASE were used as data sources, searched up to January 2024. A systematic review and meta-analysis were performed in accordance to guidelines from the Cochrane Collaboration. The primary outcomes investigated were changes in dysmenorrhea, quantified by means of VAS scores, HMB in terms of number of bleeding days, and changes in uterine volume determined at ultrasound. Twelve eligible studies were selected. Results: The results highlighted that dienogest yields a reduction in dysmenorrhea that is significantly superior to that of the rest of the medical treatments investigated (p-value of <0.0002). On the other hand, GnRH agonists seem to play a more prominent role in reducing uterine volume (p-value of 0.003). While it was not possible to determine which medical treatment better decreased the number of bleeding days, it was observed that COC performed significantly worse than the other treatments studied (p-value of 0.02). Conclusions: While this meta-analysis provides valuable insights in the comparative efficacy of different treatments, the paucity of relevant studies on the topic might impact the reliability of some of the conclusions drawn.
Cough in Protracted Bacterial Bronchitis and Bronchiectasis
Authors: Wiltingh Hinse , Marchant Julie Maree , Goyal Vikas
Published: June 2024

Chronic cough in children is a common condition for which patients seek medical attention, and there are many etiologies. Of the various causes of chronic cough in children, protracted bacterial bronchitis (PBB) is one of the commonest causes, and bronchiectasis is one of the most serious. Together, they lie on different ends of the spectrum of chronic wet cough in children. Cough is often the only symptom present in children with PBB and bronchiectasis. This review highlights the role of cough as a marker for the presence of these conditions, as well as an outcome endpoint for treatment and research.
Pharmaceutical Modulation of Intracranial Aneurysm Development and Rupture
Authors: Crane Alex , Shanahan Regan M. , Hudson Joseph S. , Nowicki Kamil W. , Gersey Zachary C. , Agarwal Prateek , Jacobs Rachel C. , Lang Michael J. , Gross Bradley
Published: June 2024

Management of intracranial aneurysms (IAs) is determined by patient age, risk of rupture, and comorbid conditions. While endovascular and microsurgical interventions offer solutions to mitigate the risk of rupture, pharmacological management strategies may complement these approaches or serve as alternatives in appropriate cases. The pathophysiology of IAs allows for the targeting of inflammation to prevent the development and rupture of IAs. The aim of this review is to provide an updated summary of different pharmaceutical management strategies for IAs. Acetylsalicylic acid and renin-angiotensin-aldosterone system (RAAS) inhibitor antihypertensives have some evidence supporting their protective effect. Studies of selective cyclooxygenase-2 (COX-2) inhibitors, statins, ADP inhibitors, and other metabolism-affecting drugs have demonstrated inconclusive findings regarding their association with aneurysm growth or rupture. In this manuscript, we highlight the evidence supporting each drug’s effectiveness.
A Feasibility Open-Labeled Clinical Trial Using a Second-Generation Artificial-Intelligence-Based Therapeutic Regimen in Patients with Gaucher Disease Treated with Enzyme Replacement Therapy
Authors: Hurvitz Noa , Dinur Tama , Revel-Vilk Shoshana , Agus Samuel , Berg Marc , Zimran Ari , Ilan Yaron
Published: June 2024

Background/Objectives: Gaucher Disease type 1 (GD1) is a recessively inherited lysosomal storage disorder caused by a deficiency in the enzyme β-glucocerebrosidase. Enzyme replacement therapy (ERT) has become the standard of care for patients with GD. However, over 10% of patients experience an incomplete response or partial loss of response to ERT, necessitating the exploration of alternative approaches to enhance treatment outcomes. The present feasibility study aimed to determine the feasibility of using a second-generation artificial intelligence (AI) system that introduces variability into dosing regimens for ERT to improve the response to treatment and potentially overcome the partial loss of response to the enzyme. Methods: This was an open-label, prospective, single-center proof-of-concept study. Five patients with GD1 who received ERT were enrolled. The study used the Altus Care™ cellular-phone-based application, which incorporated an algorithm-based approach to offer random dosing regimens within a pre-defined range set by the physician. The app enabled personalized therapeutic regimens with variations in dosages and administration times. Results: The second-generation AI-based personalized regimen was associated with stable responses to ERT in patients with GD1. The SF-36 quality of life scores improved in one patient, and the sense of change in health improved in two; platelet levels increased in two patients, and hemoglobin remained stable. The system demonstrated a high engagement rate among patients and caregivers, showing compliance with the treatment regimen. Conclusions: This feasibility study highlights the potential of using variability-based regimens to enhance ERT effectiveness in GD and calls for further and longer trials to validate these findings.
Risk Factors for Transient Hypoparathyroidism after Total Thyroidectomy: Insights from a Cohort Analysis
Authors: Graceffa Giuseppa , Lopes Antonella , Orlando Giuseppina , Mazzola Sergio , Vassallo Fabrizio , Curione Francesco , Richiusa Pierina , Radellini Stefano , Melfa Giuseppina , Scerrino Gregorio
Published: June 2024

Background: Transient hypoparathyroidism (TH) is the main post-thyroidectomy complication, significantly impacting surgical outcomes, hospitalization length, and perceived perceived quality of life understood as mental and physical well-being. This study aims to identify possible associated risk factors. Methods: We analyzed 238 thyroidectomies (2020–2022), excluding instances of partial surgery, primary hyperparathyroidism, neck irradiation history, and renal failure. The variables considered were as follows: demographics, histology, autoimmunity, thyroid function, pre- and postoperative Vitamin D levels (where available), type of surgery, number of incidentally removed parathyroid glands (IRP), and surgeons’ experience (>1000 thyroidectomies, <500, in training). Univariate analysis applied: χ2, Fisher’s exact test for categorical variables, and Student’s t-test for continuous variables. Subsequently, logistic multivariate analysis with stepwise selection was performed. Results: Univariate analysis did not yield statistically significant results for the considered variables. The ‘No Complications’ group displayed a mean age of 55 years, whereas the TH group showed a mean age of 51 (p-value = 0.055). We considered this result to be marginally significant. Subsequently, we constructed a multivariate logistic model. This model (AIC = 245.02) indicated that the absence of incidental parathyroidectomy was associated with the age class >55 years, presenting an odds ratio (OR) of 9.015 (p-value < 0.05). Simultaneously, the age class >55 years exhibited protective effects against TH, demonstrating an OR of 0.085 (p-value < 0.01). Similarly, the absence of incidental parathyroidectomy was found to be protective against TH, with an OR of 0.208 (p-value < 0.01). Conclusions: Multivariate analysis highlighted that having “No IRP” was protective against TH, while younger age was a risk factor. Surgeon experience does not seem to correlate with IRP or outcomes, assuming there is adequate tutoring and a case volume close to 500 to ensure good results. The effect of reimplantation has not been evident in transient hypoparathyroidism.
Heart Rate Recovery: Up to Date in Heart Failure—A Literature Review
Authors: Cozgarea Andreea , Cozma Dragoș , Teodoru Minodora , Lazăr-Höcher Alexandra-Iulia , Cirin Liviu , Faur-Grigori Adelina-Andreea , Lazăr Mihai-Andrei , Crișan Simina , Gaiță Dan , Luca Constantin-Tudor , Văcărescu Cristina
Published: June 2024

The rising prevalence of cardiovascular disease underscores the growing significance of heart failure (HF). Pathophysiological insights into HF highlight the dysregulation of the autonomic nervous system (ANS), characterized by sympathetic overactivity and diminished vagal tone, impacting cardiovascular function. Heart rate recovery (HRR), a metric measuring the heart’s ability to return to its baseline rate post-exertion, plays a crucial role in assessing cardiovascular health. Widely applied across various cardiovascular conditions including HF, coronary artery disease (CAD), and arterial hypertension (HTN), HRR quantifies the difference between peak and recovery heart rates. Given its association with elevated sympathetic tone and exercise, HRR provides valuable insights into the perspective of HF, beyond effort tolerance, reaching toward prognostic and mortality indicators. Incorporating HRR into cardiovascular evaluations enhances our understanding of autonomic regulation in HF, offering potential implications for prognostication and patient management. This review addresses the significance of HRR in HF assessment, analyzing recently conducted studies, and providing a foundation for further research and clinical application.
Advances and Challenges in Minimally Invasive Spine Surgery
Authors: Wang Timothy Y. , Wang Michael Y.
Published: June 2024

Minimally invasive spine surgery continues to grow and develop. Over the past 50 years, there has been immense growth within this subspecialty of neurosurgery. A deep understanding of the historical context and future directions of this subspecialty is imperative to developing safe adoption and targeted innovation. This review aims to describe the advancements, and challenges that we face today in minimally invasive spine surgery.
Three Self-Adhesive Resin Cements and Their Influence on the Marginal Adaptation of Zirconia-Reinforced Lithium Silicate Single Crowns: An In Vitro Scanning Electron Microscope Evaluation
Authors: Shely Asaf , Nissan Joseph , Lugassy Diva , Rosner Ofir , Zenziper Eran , Egbaria Tharaa , Ben-Izhack Gil
Published: June 2024

Background: In everyday dentistry, monolithic single crowns can be cemented with self-adhesive resin cements. The aim of this in vitro study was to evaluate how the marginal adaptation of full monolithic zirconia-reinforced lithium silicate (ZLS) single crowns is influenced by three different self-adhesive resin cements. Methods: Forty-five typodont teeth fully prepared for full monolithic crowns were divided into three groups (fifteen each) for the use of three different self-adhesive resin cements. A fourth control group (Temp-bond) was created by taking five teeth from each group before cementation with self-adhesive resin cements. All forty-five abutments were scanned using a Primescan intra-oral scanner (IOS), followed by computer-aided design (CAD) and computer-aided manufacturing (CAM) of zirconia-reinforced lithium silicate (ZLS) full crowns using a four-axis machine. Initially, the crowns of the control group were fixed to the abutments using Temp-bond, and the marginal gap was evaluated using a scanning electron microscope (SEM). After removing the control group crowns from the abutments, fifteen crowns in each group were cemented using a different self-adhesive resin cement and observed under SEM for evaluation of the marginal gap. A Kolmogorov–Smirnov test was performed, indicating no normal distribution (p < 0.05), followed by Mann–Whitney tests (α = 0.05). Results: The total mean marginal gap of the temp-bond control group was significantly lower compared to all three groups of self-adhesive resin cement (p < 0.0005). The total mean marginal gap of the G-cem ONE group was significantly lower compared to the TheraCem group (p < 0.026) and RelyX U200 group (p < 0.008). The total mean marginal gap of the TheraCem group was significantly higher than the G-cem ONE group (p < 0.026) but showed no significant difference with the RelyX U200 group (p > 0.110). Conclusions: All four groups showed a clinically acceptable marginal gap (<120 microns). Although all three groups of self-adhesive resin cement showed a significant increase in the marginal gap compared to the temp-bond control group, they were within the limits of clinical acceptability. Regarding the marginal gap, in everyday dentistry, it is acceptable to use all three self-adhesive resin cements, although the G-cem ONE group exhibited the lowest marginal gap for ZLS single crowns.
Cardiac Adaptation in Power Athletes: Differential Impact of Judo and Weightlifting
Authors: Di Gioia Giuseppe , Ferrera Armando , Maestrini Viviana , Monosilio Sara , Squeo Maria Rosaria , Lemme Erika , Nenna Antonio , Calaciura Clarich Sofia , Crotta Simone , Pelliccia Antonio
Published: June 2024

Background: According to the ESC guidelines, sport disciplines are classified in relation to the predominant component (skill, power, mixed and endurance), including a wide range of disciplines with different isometric/isotonic exercises and exercise-induced heart remodeling. The aim of our study was to evaluate differences in morpho-functional cardiac adaptations in power athletes, comparing judokas with weightlifters. Methods: We enrolled 55 Olympic athletes (38 judokas, 17 weightlifters), aged 24.5 ± 3.8 years, 25 (45.4%) of whom were males, and they underwent a pre-participation evaluation, including a physical examination, ECG, transthoracic echocardiogram, and exercise stress test. Results: The judokas presented significant differences in cardiac adaptations, with larger left ventricle (LV) end-diastolic and end-systolic volumes indexed (LVEDVi, p = 0.002 and LVESVi, p = 0.004) and higher LVMass values indexed (p = 0.033), but similar LV wall thicknesses (p = 0.093) and LV ejection fractions (p = 0.981). Also, the left atrium (LA) dimension (p = 0.0002) and volume indexed (p < 0.0001) were higher in the judokas, as were the larger right ventricle (RV) areas. Finally, the judokas showed higher VO2max (p = 0.012), O2 pulse (p = 0.007), VE/O2 LT1 (p = 0.041) and VE/O2 LT2 (p = 0.036) values, with a lower resting heart rate (p = 0.031) and higher exercise capacity (p = 0.011). Conclusions: The judokas showed substantial differences in cardiac morpho-functional adaptations from the weightlifters, and, accordingly, judo should be more properly considered not a pure strength sport but more similar to mixed disciplines of the ESC classification.
Outcomes of Revascularisation for Treating Lifestyle-Limiting Intermittent Claudication in Aboriginal and Torres Strait Islander People and Non-Indigenous Patients from North Queensland: A Retrospective Cohort Study
Authors: Wong Shannon , Thanigaimani Shivshankar , Charles James , Whaleboat Donald , Golledge Jonathan
Published: June 2024

Background: This retrospective analysis of an ongoing prospective cohort study aimed to assess the outcome of revascularisation for treating lifestyle-limiting intermittent claudication caused by peripheral artery disease (PAD) in Aboriginal and Torres Strait Islander Peoples and non-Indigenous North Queenslanders. Methods: Consenting patients with PAD who underwent endovascular or open revascularisation procedures for treating lifestyle-limiting intermittent claudication were included. The primary outcome measure was major adverse limb events (MALEs), defined as major amputation or the requirement for repeat open or endovascular revascularisation. Results: Of the 378 included patients, 18 (4.8%) identified as Aboriginal and/or Torres Strait Islander Peoples. During a mean follow-up (standard deviation) of 6.0 (3.9) years, the incidence of MALE was similar in the Aboriginal and Torres Strait Islander People and non-Indigenous Australians (absolute percentage: 50.0% vs. 40.6%, log rank p = 0.59). In both unadjusted and adjusted analyses, Aboriginal and Torres Strait Islander Peoples and non-Indigenous Australians had similar risks of MALE (unadjusted hazard ratio, HR, 1.20, 95% confidence interval, CI, 0.61, 2.36; adjusted HR 1.02, 95%CI 0.50, 2.06). Conclusions: This study suggests that Aboriginal and Torres Strait Islander People are under-represented in the population of patients undergoing revascularisation to treat intermittent claudication. Due to small numbers it cannot be reliably concluded that Aboriginal and Torres Strait Islander People and non-Indigenous Australians have similar rates of MALE.
Anxiety, Depression, and Quality of Sleep Vary in Their Correlation to Postoperative Outcomes of Rotator Cuff Repair: A Prospective Study
Authors: Longo Umile Giuseppe , Marino Martina , Candela Vincenzo , Greco Alessandra , Piergentili Ilaria , Arias Claudia , de Sire Alessandro , D’Hooghe Pieter
Published: June 2024

Background/Objectives: Recent studies imply that psychological factors and sleep quality play a role in the outcomes of surgical procedures, including in orthopedic surgery. The aim of the present study is to evaluate possible correlations between preoperative depression, anxiety, and quality of sleep and functional 6-month postoperative scores in patients having undergone rotator cuff repair (RCR). Methods: All patients included in the study performed the Hospital Anxiety and Depression Scale (HADS) and Pittsburgh Sleep Quality Index (PSQI) questionnaires preoperatively and 36-item Short-Form Health Survey (SF-36), Oxford Shoulder Score (OSS), Shoulder Pain and Disability Index (SPADI), and PSQI questionnaires at the six-month postoperative follow-up. A total of 47 patients were included in the analysis. Results: Statistically significant differences between preoperative anxious and not-anxious groups were found in the postoperative SF-36 Physical Component Summary (PCS) and Mental Component Summary (MCS) scores and PSQI score. The correlation of the preoperative depression score to postoperative outcome measures revealed a strong positive correlation between the preoperative HADS-D score and the 6-month PCS, MCS, and OSS scores. The correlation of preoperative sleep quality to postoperative outcome measures revealed a strong positive correlation between the preoperative PSQI score and 6-month MCS score. Conclusions: Anxious patients had worse postoperative RCR outcomes. Depression may be influenced by factors related to RC pathology; however, there were no statistically significant correlations. Sleep quality generally improves postoperatively, and no significant association was found between bad preoperative sleepers and worse outcomes.
Long-Term Evaluation of Tooth Transplantation: An Umbrella Review
Authors: Jaber Mohamed , Prasad Prathibha , Akeil Mohammad , Moufti Abdulrahman , Al-Sammarraie Almustafa , Charaf Eddin Chuaeib
Published: June 2024

Aim/Objective: This umbrella review of systematic reviews aims to summarize the available data regarding both success and survival rates of tooth autotransplantation, in addition to analyzing the risk factors that are connected to those rates. Methods: This umbrella review was performed according to the evaluation of various meta-analyses and systematic reviews following AMSTAR2 guidelines. A systematic search of literature on PubMed, Scopus, MEDLINE, EMBASE, and the Cochrane Database. Six systematic reviews were included. Explicit inclusion and exclusion criteria were applied. It is registered in PROSPERO under the registration number (CRD-42023415623). Results: The studies reviewed were written from 2014 to 2018, which extracted the information from various studies spanning from 1968 to 2014. According to the selected studies regarding autotransplanted teeth in humans, they showed the following: A survival rate overall of 87.39% and a success rate overall of 90.29%. These factors were the most common in relation to the success of the autotransplanted teeth: age, gender, and stage of root development. On the other hand, common unfavorable results linked to the transplanted teeth in these studies were failure, ankylosis, and internal root resorption, followed by extraction and hypermobility. Conclusions: The wide body of evidence gathered illustrates that autotransplantation is an operation that dispenses high rates of survival and success. Furthermore, risk factors like root development stage, recipient site, and donor tooth type established a remarkable association with the negative outcomes of the procedure. For successful tooth autotransplantation, patient selection is crucial. Younger patients and those with donor teeth at an optimal stage of root development typically experience better outcomes. Preoperative planning should include comprehensive evaluations and advanced imaging techniques to accurately assess both the donor tooth and the recipient site. Nonetheless, on account of heterogeneity and the quality of the studies included in this investigation, caution should be taken when interpreting the mentioned results.
Functionalized Surface Coatings for Rigid Contact Lenses
Authors: Refaei Roeya , Lee Kyueui , Lee Goun Amy , Demian Paul , El Mansouri Fouad , Messersmith Phillip B. , Lamrani Mouad , Khaddor Mohamed , Allali Nabil
Published: June 2024

This research evolves into a comparative study of three different phenolic composites as coatings for rigid contact lenses, with a particular emphasis on enhancing their antifouling properties and hydrophobicity. The primary layer, comprised of diverse phenolic compounds, serves as a sturdy foundation. An exclusive secondary layer, featuring synthetic peptoids, is introduced to further minimize biofouling. Validated through X-ray photoelectron spectroscopy, the surface analysis confirms the successful integration of the polyphenolic layers and the subsequent grafting of peptoids onto the lens surface. The efficacy of the proposed coatings is substantiated through protein adsorption tests, providing definitive evidence of their antifouling capabilities. This research employs a nuanced assessment of coating performance, utilizing the quantification of fluorescence intensity to gauge effectiveness. Additionally, contact angle measurements offer insights into wettability and surface characteristics, contributing to a comprehensive understanding of the coating’s practicality.