bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of CFTR modulatory therapies on liver function and fibrosis indices in cystic fibrosis patients: a retrospective analysis from two Romanian medical centers
Authors: Moiceanu Elena-Simona , Stan Iustina Violeta , Moșescu Simona Elena , Leucuța Daniel-Corneliu , Iacobescu Maria , Nițescu Gabriela Viorela , Vivisenco Iolanda Cristina , Petran Elena Mădălina , Dumitrașcu Dan Lucian
Published: October 2024

Background. Patients with cystic fibrosis (CF) frequently require modulatory therapies such as Lumacaftor/Ivacaftor (LI) and Elexacaftor/Tezacaftor/Ivacaftor (ETI) to manage their condition. Given the potential hepatic complications associated with CF, it is critical to understand the impact of these therapies on liver function and fibrosis indices. This study aimed to evaluate the changes in liver function markers and fibrosis indices in CF patients undergoing LI and ETI therapies, with a specific focus on the influence of underlying hepatic disease.
Methods. In this retrospective analysis, liver function markers and fibrosis indices were assessed in CF patients receiving ETI (n=24), LI (n=4), or a combination of both (LI/ETI, n=8). Key liver function markers, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, platelet count, and fibrosis indices (APRI and FIB-4), were measured at baseline and at various time points up to 12 months.
Results. In patients receiving LI therapy, ALT and AST levels demonstrated a slight but non-significant decrease over six months, accompanied by significant fluctuations in total bilirubin levels. Among those receiving ETI therapy, ALT and AST levels initially increased but stabilized over time, while total bilirubin levels significantly increased from baseline to 12 months. No significant differences were observed in liver function markers between patients with and without hepatic disease under ETI therapy. Trends in fibrosis indices (APRI and FIB-4) were modest and largely non-significant across both therapies.
Conclusions. ETI therapy appears to be safe for CF patients, including those with pre-existing hepatic disease, with no significant deterioration in liver function over a 12-month period. However, the observed fluctuations in bilirubin levels underscore the necessity for ongoing monitoring. Further research is warranted to investigate the long-term hepatic effects of LI and ETI therapies.
Online teaching-learning at university level education from psychological perspective and consequences: A post-COVID scenario
Authors:   Indira Gandhi National Open University, Patel Jainish , Patel Prittesh ,   Uka Tarsadia University
Published: October 2024

Present study focused on exploring the impact and consequences of online teaching and learning at the university level from the psychological standpoint using an interpretive questionnaire and a barrage of qualitative literature. Of the 143 student enrolled from India, 72.7% preferred the offline/physical classroom learning mode against only 27.3% that preferred the online. 43.8% students think that online teaching is not as effective as the offline that has been in use since over the years. Obtaining the impact of online teaching, only 25.6% agreed that online teaching had made positive impact on their mind, while 33.6% stated no impact. These results suggest that student believe their diligence to education yields more outcomes with traditional learning environments than with online education.
Evaluation of different methods for reference evapotranspiration assessment: A case study for Ukraine
Authors: Lykhovyd P. V. , Averchev O. V. , Bidnyna I. O. , Avercheva N. O. , Nikitenko M.
Published: October 2024

The paper presents the results of the study devoted to the examination of the accuracy and reliability of the temperature-based approach of the ‘Evapotranspiration Calculator (Ukraine)’ application for the reference evapotranspiration assessment in Ukraine. The objective of the study was to determine the level of reliability and accuracy of modern alternative temperature-based algorithms for the reference evapotranspiration assessment in Ukraine compared to internationally recognized methods. The study was carried out for the territories of Ukraine, based on the meteorological data for the period 2021–2023. The basic methodology was compared to the standard Penman-Monteith method and the method of Hargreaves. The comparison was performed using the values of MAPE, RMSE, and correlation coefficient. Statistical analysis testified that there is a strong correlation and subtle difference between the Hargreaves method and the ‘Evapotranspiration Calculator (Ukraine)’ application, with an average MAPE of 30.3%, the correlation coefficient of 0.92, and RMSE of 1.46 mm. The difference between the Penman-Monteith method and the studied methodology was greater, as the MAPE averaged 41.0%, the correlation coefficient was 0.87, and the RMSE value was 2.05 mm. However, the high variation of the results by the regions of the country and the years of the study did not allow us to draw solid conclusions on whether the methodology embedded in the ‘Evapotranspiration Calculator (Ukraine)’ application is inferior to the method of Penman-Monteith. Further studies are required to clarify this issue through the improvement in the dataset, involvement of in-field reference evapotranspiration measurements, and application of adjustment guidelines for the ‘Evapotranspiration Calculator (Ukraine)’ application.
Serum TNF-α and IL-10 levels during chronic carrageenan inflammation with thrombin inhibitor administration in rats
Authors: Shevchenko V. O. , Pavlova O. O.
Published: October 2024

Inflammatory cytokines are key mediators involved in the activation of the blood coagulation system, influencing various coagulation mechanisms, while activated coagulation proteases, physiological anticoagulants, and fibrinolytic system components can, conversely, modulate inflammation through specific cellular receptors. This study investigated the impact of the thrombin inhibitor dabigatran etexilate on a rat model of secondary chronic aseptic inflammation induced by an intramuscular injection of 10 mg of λ-carrageenan in 1 mL of isotonic saline into the right thigh of rats. Dabigatran etexilate was administered intragastrically via gavage at a dose of 15 mg/kg/day in 1 mL of isotonic saline daily for 28 days. Peripheral blood samples were collected on days 0, 1, 7, 14, 21, and 28 to determine serum TNF-α and IL-10 levels. During the natural course of secondary chronic carrageenan-induced inflammation, serum TNF-α levels increased until day 14 and subsequently decreased gradually towards day 28. Serum IL-10 levels during the natural course rose until day 21, followed by a slight drop on day 28. The administration of dabigatran etexilate modulated these cytokine dynamics, leading to a reduction in TNF-α levels compared to the natural course, particularly on days 14 and 21. Notably, IL-10 levels were significantly higher from day 1 to day 21 during dabigatran etexilate administration and exhibited a biphasic response, with a significant peak on day 7 and the highest levels observed on day 21. These distinct TNF-α and IL-10 level dynamics suggest a strong interaction between proinflammatory and anti-inflammatory processes. Dabigatran etexilate influenced the cytokine profile during chronic inflammation, potentially mitigating the inflammatory response as evidenced by the altered TNF-α and IL-10 levels. These findings highlight the potential of thrombin inhibitors, specifically dabigatran etexilate, in modulating inflammatory responses, warranting further investigation into its therapeutic mechanisms. Future research should focus on exploring the specific mechanisms through which dabigatran etexilate, and potentially other thrombin inhibitors, exert their anti-inflammatory effects, including their influence on humoral mediators relevant to the pathogenesis of chronic inflammation.
Assessment of cystatin C and CCL14 as predictive and diagnostic biomarkers for contrast-induced nephropathy
Authors: Mahmood K. A. , Ewadh M. J. , Al-Saad S. F.
Published: October 2024

Contrast-induced nephropathy (CIN) is kidney dysfunction caused by radiocontrast agents, occurring 48–72 hours after their administration. The early prediction of CIN would be valuable in order to limit the damage caused by this condition. The present study aimed to evaluate the serum levels of chemokine (C-C) motif ligand-14 (CCL14), insulin-like growth factor-binding protein-7 (IGFBP7), cystatin C, and creatinine as novel biomarkers that predict contrast-induced nephropathy. This study aimed to assess the predictive value of cystatin C and CCL14 biomarkers for CIN development. The ELISA test was used to quantify serum levels of CCL14, IGFBP7, and cystatin C 2 days after exposure to contrast media in 44 patients with normal renal function before being scheduled to undergo coronary angiography (control group) and 2 days after exposure to contrast media in the contrast-induced nephropathy (CIN) group, and all data were compared. Levels of serum creatinine in CIN and control groups were also compared. The levels of the three biomarkers at 2 days after exposure to contrast media in the CIN group were significantly higher than those in the control group, while the level of serum creatinine was significantly higher than that in the control group. Moreover, the levels of CCL14, IGFBP7, and cystatin C were positively correlated with serum creatinine at 2 days after exposure to contrast media in the CIN group. This study demonstrated that the serum levels of CCL14, IGFBP7, and cystatin C could be potential predictors for CIN.
Geração de ondas irregulares realísticas através da metodologia WaveMIMO
Authors: Paiva Maycon da Silveira , Mocellin Ana Paula Giussani , Oleinik Phelype Haron , Santos Elizaldo Domingues dos , Rocha Luiz Alberto Oliveira Rocha , Isoldi Liércio André , Neves Machado Bianca Neves
Published: October 2024

Dentre as diversas fontes renováveis de energia que podem ser exploradas, têm-se a energia contida nas ondas do mar. A metodologia WaveMIMO é utilizada para a geração numérica de ondas irregulares baseadas em estados de mar realísticos e consiste em tratar dados espectrais para a obtenção de perfis de velocidade orbital de propagação das ondas, que são impostos como condição de contorno (CC) em um canal de ondas numérico. Nesse sentido, o presente estudo avalia parâmetros para a aplicação desta metodologia, onde se investigou a discretização da região de imposição da CC de velocidade prescrita, a sensibilidade de malha na região da superfície livre, o passo de tempo empregado e, por fim, a localização do vetor de velocidades em cada segmento da região de imposição da CC de velocidade prescrita. Para tanto, foram considerados dados realísticos referentes a um ponto próximo à costa do município de Mostardas, no estado do Rio Grande do Sul, obtidos do modelo espectral TOMAWAC. Os resultados indicaram que, comparando o melhor e o pior caso avaliado, obteve-se melhorias de 6,58% e 7,60% nas métricas consideradas nas avaliações dos resultados.
Seismic demand evaluation of reinforced-concrete buckling-restrained braces for precast concrete frames
Authors: Oh Shane , Mohle Jon , Pearson Lily A. , Manning Mark P. , Weldon Brad D. , Kurama Yahya C.
Published: October 2024

This paper reports on an evaluation of two models for calculating the shear strength of prestressed ultra-high-performance concrete (UHPC) beams. Calculations from these models, referred to as the eCPCI and FHWA (Federal Highway Administration) models, were compared to a database of experimental test results compiled from the literature. Identifying comparable UHPC material properties from the published literature was a challenge because different testing programs used different material tests. Accordingly, UHPC localized tensile strength was estimated based on the available data and approximate ratios. In addition to the experimental database, a machine-learning prediction model was developed to generate a simulation database used for further evaluation of the eCPCI and FHWA models. On average, the FHWA model resulted in shear capacity estimates that were 17% lower than the eCPCI method. However, the analyses show that shear strength predictions from both the FHWA and eCPCI models were typically conservative relative to data from the experimental and simulated databases. In addition, both models were observed to produce less-accurate estimates for larger-sized specimens than for smaller specimens.
Oscillometric method: what is it and is it suitable for measuring blood pressure in all patients?
Authors: Posokhov I. N. , Maroz-Vadalazhskaya N. N.
Published: October 2024

The oscillometric method, which is gradually replacing the traditional auscultatory method, is attractive to practitioner due to the possibility of automating blood pressure (BP) measurements. However, there is little literature information about its limitations. The purpose of this review is to address such issues. For this purpose, the main modern information on the maximum amplitude algorithm for BP measurement and location features, in which it is possible to obtain an oscillometric waveform, are preliminarily considered. In addition, the limitations and disadvantages of the method associated with both the equipment and the characteristics of various population groups are analyzed. The list of groups in which blood pressure measuring devices may be inaccurate has expanded significantly in the 2020s compared to the previous decade. This suggests that the reliability of the interpretation of data obtained by the oscillometric method in a certain part of patients is limited.
Cardiopulmonary exercise testing in patients with precapillary pulmonary hypertension with an unfavorable prognosis
Authors: Berezina A. V. , Zlobina I. S. , Goncharova N. S. , Simakova M. A. , Lapshin K. B. , Moiseeva O. M.
Published: October 2024

Aim. To compare clinical and hemodynamic parameters with survival of incident patients with idiopathic pulmonary arterial hypertension (IPAH) and chronic thromboembolic pulmonary hypertension (CTEPH) with a prognostically unfavorable pattern of cardiopulmonary exercise testing (CPET) parameters.

Material and methods. The study included 48 incident cases with a verified diagnosis of IPAH (n=18) and CTEPH (n=30). All patients were examined in accordance with the European Society of Cardiology and the European Respiratory Society guidelines (2015). The inclusion criterion was the ventilatory equivalent for carbon dioxide (CO2) according to the CPET (VE/VCO2) >44, indicating an unfavorable prognosis for patients.

Results. VE/VCO2 in the examined patients with IPAH and CTEPH averaged 70,6±0,8 and did not differ in the study groups. Hemodynamic parameters of patients with IPAH and CTEPH also indicated a high risk of adverse events as follows: cardiac index — 1,9±0,1 and 1,8±0,1 l/min/m2, respectively (p=0,3). Peak oxygen consumption, anaerobic threshold level, oxygen delivery to work performed were reduced in both groups. However, patients with IPAH did not have a decrease in dead space ventilation and desaturation severity during exercise was greater than in patients with CTEPH. Patients with CTEPH had better survival compared to patients with IPAH: 1 year — 89 vs 83%, 3 years — 84 vs 65%, 5 years — 73 vs 35%, 7 years — 55 vs 36%.

Conclusion. Among patients with IPAH and CTEPH who have an unfavorable prognosis, patients with IPAH demonstrate a more pronounced decrease in cardiovascular and respiratory reserves, which negatively affects patient survival. CPET may be a valuable non-invasive method for death risk stratification in patients with IPAH and CTEPH.
Dietary habits and all-cause mortality risk in the adult population. Results of a 6-year prospective follow-up of the ESSE-RF study cohort
Authors: Karamnova N. S. , Kapustina A. V. , Kutsenko V. A. , Shvabskaia O. B. , Balanova Yu. A. , Evstifeeva S. E. , Imaeva A. E. , Kotova M. B. , Maksimov S. A. , Muromtseva G. A. , Kulakova N. V. , Kalachikova O. N. , Chernykh T. M. , Belova O. A. , Artamonova G. V. , Grinshtein Yu. I. , Libis R. A. , Rotar O. P. , Trubacheva I. A. , Efanov A. Yu. , Shalnova S. A. , Drapkina O. M.
Published: October 2024

Dietary habits affect the risk of all-cause mortality (ACM) in the adult population according to prospective studies.

Aim. To assess the effect of dietary habits on the ACM risk in the Rus­sian population.

Material and methods. The prospective cohort included represen­ta­tive samples of 10 Russian regions (n=17175, 6767 men and 10408 wo­men aged 25-64 years), examined in 2012-2014 as part of the ESSE-RF study. Dietary habits were studied based on the consumption rate of the main food groups. The vital status of the cohort was updated every 2 years. The follow-up period was 6 years. Kaplan-Meier curves were used to analyze overall survival (OS). Cox proportional hazards model was used to assess the ACM risk.

Results. In the Russian population, an increase in OS is associated with daily consumption of vegetables/fruits, dairy products (milk, kefir, yogurt, cottage cheese, and cheese), and the presence of the Heal­thy Eating Model (HEM) in the diet. A decrease in OS is associated with excess salt intake (ESI) in the diet, the habit of adding salt to pre­pared foods, and daily consumption of pickles (p<0,05). Among men, an increase in OS is observed with daily consumption of fruits/ve­ge­tables, cheese, and HEM, while a decrease is observed with daily consumption of pickles, general ESI, and the habit of adding salt to foods (p<0,05). In women, daily consumption of red meat, liquid dairy products, cheese, and sweets is associated with an increase in OS (p<0,05). The risk of ACM in the general population and among men increases with ESI — relative risk (RR)=1,31 [1,06-1,61] (p=0,012) and 1,41 [1,06-1,87] (p=0,017), respectively, adding salt to food — RR=1,34 [1,09-1,65] (p=0,006) and 1,5 [1,13-1,98] (p=0,005) and daily consumption of pickles — RR=1,48 [1,02-2,14] (p=0,039) and 1,5 [1,01-2,54] (p=0,045). In women, regular consumption of red meat — RR=0,7 [0,49-0,99] (p=0,043), liquid dairy products — RR=0,68 [0,5-0,93] (p=0,015) and cheese — RR=0,64 [0,46-0,9] (p=0,011) were associated with an ACM decrease.

Conclusion. An ACM risk increase in the general population and among men is associated with excess salt intake, and a decrease in ACM risk in women is associated with the regular inclusion of red meat and dairy products in the diet.
«… fordi skolen skal jo hjelpe deg i fremtiden.»
Authors: Røise Petra , Skovhus Randi Boelskifte
Published: October 2024

Formålet med artikkelen er å gi innsikt i hvilken betydning ungdomsskoleelever tillegger utplasseringsaktiviteter, og hvordan dette er forbundet med betingelser knyttet til utplassering. Artiklens empiri består av fire fokusgrupper med totalt 24 ungdomsskoleelever som har deltatt i utplasseringsaktiviteter. Det teoretiske fundament er kritisk psykologi og kritisk pedagogikk. Med dette rammeverket analyseres frem fem temaer, nemlig: 1) at elever har ulike begrunnelser for hva de tillegger betydning ved utplassering; 2) refleksive og relasjonelle dimensjoner kan styrke betydningen av utplassering; 3) elevenes forventninger til arbeid og betingelser for å kunne utføre arbeidet; 4) hvis utplassering skal bidra til utdanningsvalg, ønsker elevene innsikt i hele yrke; og til slutt, 5) at mange elever ønsker mer utplassering, men ikke under alle betingelser. Det diskuteres hvordan studiens funn kan bidra til utvikling av karriereundervisning og didaktisk forståelse i faget utdanningsvalg i Norge, med særlig fokus på utplasseringsaktiviteter.
Análise da situação vacinal contra a Mpox em pessoas vivendo com HIV/Aids: estudo ecológico
Authors: Tavares Núbia Vanessa da Silva , Santos Amuzza Aylla Pereira dos , Carvalho Mariana Maria Pereira Cintra Farias , Melo Kariane Omena Ramos Cavalcante de , Oliveira Hillary Gabriela dos Santos , Bernardo Thaís Honório Lins , Calheiros Selma Sabrina de Albuquerque , Santos José Augustinho Mendes
Published: October 2024

RESUMO Objetivos: analisar a situação vacinal contra a Mpox em pessoas vivendo com HIV/Aids no Brasil. Métodos: estudo ecológico sobre a situação vacinal contra a Mpox das pessoas vivendo com HIV/Aids (PVHA) no Brasil. Os dados foram coletados em abril de 2023 através de informações do Ministério da Saúde, denominada “Microsoft app Power BI”, de acesso público. Resultados: a análise dos dados revelou que foram administradas, no Brasil, 2.978 doses da vacina MVA-BN Jynneos Mpox em PVHA, correspondendo a uma cobertura vacinal de 18,3%, sendo as regiões sul e sudeste as que apresentaram a menor e maior cobertura vacinal, respectivamente. A avaliação por sexos mostrou maior proporção de vacinados do sexo masculino. Conclusões: identificamos baixas coberturas vacinais em todas as regiões do Brasil, expondo a necessidade de intensificação nas atividades de vacinação, sobretudo para as PVHA.
Navigating the Landscape of Periodontitis Nonsurgical Treatment: A Metatrend Study of The Scientific Production and Trends From 2001-2020
Authors: Abdo Victoria L , Dini Caroline , Borges Maria Helena R , Domingues Danilo V A P , Sanchez Kamily A C C , Martins Rodrigo , Retamal-Valdes Belen , Barão Valentim A R , Souza Joāo Gabriel S
Published: October 2024

Abstract Nonsurgical therapies have been recommended and employed as a less invasive and cost-effective modality in managing periodontitis. In this context, different therapeutic protocols have been tested in the last decades. Therefore, mapping the scientific trends and patterns provides critical insights into the state of research in the field, which has not been explored for overall nonsurgical periodontitis treatment studies. Articles from 2001 to 2020 were retrieved from the Web of Science database using appropriate terms and keywords. Article selection and data extraction were performed by calibrated examiners. All articles focusing on nonsurgical periodontitis treatment were included. Descriptive, bivariate, and multivariate logistic regression analyses were conducted. 1,519 articles were included. Randomized clinical trials (RCTs) were the most used design (44.1%), and professional biofilm control was the topic most studied (35.6%). Europe published the most significant number of articles (41.1%). The USA was the country that collaborated more with other countries. Asia (p<0.001), South America (p=0.004), and Oceania/Africa (p=0.016) showed a lower chance to have international collaboration. Studies from North America were more likely to be RCTs than studies from Europe (p=0.050); studies focusing on professional biofilm control (p<0.001) and other topics (p<0.001) were less likely to be evaluated by RCTs. The nonsurgical periodontitis treatment field mainly conducted RCTs, and the topic most explored by all studies was professional biofilm control. International collaboration and conduct of RCTs in this field occurred mainly among high-income countries. Decentralizing scientific resources, making integrative connections globally, and evaluating new topics may improve evidence-based periodontology.
Management of Infected Tissues Around Dental Implants: A Short Narrative Review
Authors: Alghamdi Hamdan , Leventis Minas , Deliberador Tatiana
Published: October 2024

Abstract Dental implants have become the most effective treatment option for replacing missing teeth, worldwide. The popularity and demand for dental implants are continually increasing. Nevertheless, its complications are undeniable. Peri-implant diseases, including peri-implant mucositis and peri-implantitis, are a multifaceted clinical condition. Therefore, it is in the best interest to optimize the management of peri-implantitis, and there are still numerous methods to treat and manage infections in the vicinity of dental implants. The main goal of peri-implantitis treatment is to arrest disease progression, eliminate infection, and reconstruct damaged tissues around the implant. The clinical evidence on treating peri-implantitis that is available in PubMed was reviewed. Additionally, we presented the most comprehensive management strategies. As a result, numerous clinical trials recommended mechanical debridement and local administration of antimicrobial agents as well as topical oxygen therapy to mitigate bacterial biofilm and manage infection. The regenerative (bone grafting) approach for the treatment of peri-implantitis is another effective method. Finally, implant surface engineering can address high antibacterial efficacy and site-specific biofilm reduction.
Response of rural landscape disturbance changes to human activities in karst mountainous areas
Authors: Han Huiqing , Zhu Jian , Liu Yue , Zhang Yingjia
Published: October 2024

ABSTRACT: Landscape patterns in mountainous areas with rapid economic development are strongly affected by multiple human activities. However, the changes in landscape disturbances across karst mountainous areas attributed to complex human activities remain unclear. Research on the degree of landscape disturbance in mountainous areas under the influence of human activities is of great significance to the conservation and scientific management of mountainous landscapes. We selected rural zones with four typical small-scale landform types in karst mountainous areas as the research objects and analyzed the response of changes in rural landscape disturbance to human activity in these areas. Our results revealed that the landscape disturbance degree and human activity influence index increase in the majority of karst mountainous areas. The changes in human activity and landscape disturbances are generally observed in the low terrain relief region. High-intensity land use associated with rapid economic development has a serious negative impact on the degree of landscape disturbance, while ecological restoration projects exert a positive impact. Accelerating the implementation of the grain for green project and regulating the unregulated expansion of production and living land are crucial measures for the ecological management in karst mountainous areas. Future ecological management strategies should focus on relatively flat terrain areas. Our findings contributed to the landscape management and human activity regulation of different small-scale landform types in karst mountainous areas.
Yield and nutritional composition of sweet potatoes storage roots in response to cultivar, growing season and phosphate fertilization
Authors: Nunes Jason Geter da Silva , Leonel Magali , Fernandes Adalton Mazetti , Nunes Jesion Geibel da Silva , Figueiredo Ricardo Tajra de , Silva Jéssica Aparecida da , Menegucci Nathane Colombo
Published: October 2024

ABSTRACT: Sweet potato is an important food security crop, and the world market for this root is on the rise. Based on the physiological changes in plants in response to climatic conditions and fertilization, this study evaluated the effects of the growing season (rainy and dry season) and P2O5 doses (0, 50, 100, 200 and 400 kg ha-1) on total yield, marketable classes yields, as well as chemical composition of storage roots of two sweet potato cultivars. The storage roots yield was greater in the rainy season. The optimum agronomic and economic doses were 128 and 95 kg ha-1 P2O5 for the cultivar Canadense. Cultivar Uruguaiana did not respond to phosphate fertilization, but its storage roots had higher contents of dry matter, lipids, fibers, total and reducing sugars, and starch. Sweet potato cultivation in the rainy season with doses up to 100 kg ha-1 P2O5 increase root yield in marketable size classes in higher economic value and with higher carbohydrate contents. The results can help producers schedule the planting and harvesting of sweet potatoes throughout the year and contribute to the seasonal management of phosphate fertilizer application.
Calidad de vida, percepción de la salud, motivación para el aprendizaje y comportamiento de adolescentes en una institución educativa
Authors: Fernandes Graziela Nunes Alfenas , Lemos Stela Maris Aguiar
Published: October 2024

Objetivo: analizar variables sociodemográficas, calidad de vida, autopercepción de la salud, motivación para el aprendizaje y comportamiento de adolescentes en 2018 y 2021. Método: estudio transversal observacional con 124 adolescentes en 2018 y 68 en 2021. Para la recolección de datos se utilizó un formulario para las variables sociodemográficas, Cuestionario de Calidad de Vida Pediátrica, instrumento de Autopercepción de la Salud, Escala de Motivación para el Aprendizaje y Cuestionario de Capacidades y Dificultades. La recolección de datos se realizó mediante formularios en Google Forms . Para el análisis se utilizó estadística descriptiva y regresión logística. Resultados: la mayoría de los participantes pertenecían a la clase A. En la comparación entre 2018 y 2021, hubo un empeoramiento en la evaluación de la autopercepción de la salud. En la evaluación de la CV por parte de los padres, hubo diferencia estadísticamente significativa entre las puntuaciones de las dimensiones social y psicosocial. Entre los adolescentes, hubo diferencias entre las puntuaciones de la CV en las dimensiones física y psicosocial. Conclusión: el adolescente con mejor evaluación de la salud mental tuvo mayores posibilidades de tener una mejor calidad de vida en los períodos investigados (OR=5,35 y OR=5,51). Los estudiantes más jóvenes mostraron una mayor motivación para aprender, aumentando la posibilidad de mejorar su calidad de vida hasta 9,75 y 5,02 veces en los dos periodos, respectivamente.
Quality of life, health perception, learning motivation and behavior of adolescents in an educational institution
Authors: Fernandes Graziela Nunes Alfenas , Lemos Stela Maris Aguiar
Published: October 2024

Objective: to analyze sociodemographic variables, quality of life, self-perceived health, learning motivation and behavior of adolescents in 2018 and 2021. Method: observational cross-sectional study with 124 adolescents in 2018, and 68 in 2021. A Form for sociodemographic variables, Pediatric Quality of Life Inventory, Self-Perceived Health instrument, Learning Motivation Scale and Strengths and Difficulties Questionnaire were used to collect data. Data collection was carried out using forms on Google Forms. For the analysis, descriptive statistics and logistic regression were used. Results: the majority of participants belonged to class A. In the comparison between 2018 and 2021, there was a worsening in the assessment of self-perceived health. In the assessment of QoL by parents, there was a statistically significant difference between the scores of the social and psychosocial dimensions. Among adolescents, there were differences between QoL scores in the physical and psychosocial dimensions. Conclusion: the adolescent with a better mental health assessment had a greater chance of having a better quality of life in the periods investigated (OR=5.35 and OR=5.51). Younger students showed greater motivation to learn, increasing the chance of improving their quality of life by up to 9.75 and 5.02 times in the two periods, respectively.
Qualidade de vida, percepção de saúde, motivação para aprendizagem e comportamento de adolescentes em instituição de ensino
Authors: Fernandes Graziela Nunes Alfenas , Lemos Stela Maris Aguiar
Published: October 2024

Objetivo: analisar as variáveis sociodemográficas, qualidade de vida, autopercepção de saúde, motivação para aprendizagem e comportamento de adolescentes em 2018 e 2021. Método: estudo transversal observacional com 124 adolescentes em 2018 e 68 em 2021. Utilizou-se para a coleta de dados um Formulário para as variáveis sociodemográficas, Questionário Pediátrico de Qualidade de Vida, instrumento de Autopercepção de Saúde, Escala de Motivação para a Aprendizagem e Questionário de Capacidades e Dificuldades. A coleta dos dados foi realizada por formulários no Google Forms . Para a análise, utilizou-se estatística descritiva e regressão logística. Resultados: a maioria dos participantes pertencia à classe A. Na comparação entre 2018 e 2021, houve piora da avaliação de autopercepção de saúde. Na avaliação da QV pelos pais, houve diferença estatística significativa entre os escores das dimensões social e psicossocial. Entre os adolescentes, houve diferenças entre os escores da QV nas dimensões física e psicossocial. Conclusão: o adolescente com melhor avaliação da saúde mental teve maior chance de ter melhor qualidade de vida nos períodos investigados (OR=5,35 e OR=5,51). Estudantes mais novos apresentaram maior motivação para aprender, sendo que aumentaram em até 9,75 e 5,02 vezes a chance de melhoria da qualidade de vida nos dois períodos, respectivamente.
Uso de la Teleenfermería en el tratamiento conservador de pacientes con insuficiencia renal crónica: revisión de alcance
Authors: Biancamano Aline de Oliveira , Camacho Alessandra Conceição Leite Funchal , Cortez Elaine Antunes , Menezes Harlon França de , Almeida Yasmin Saba de , Rocha Cristiele Costa da Matta
Published: October 2024

Objetivo: mapear la evidencia del uso de la teleenfermería en la adherencia al tratamiento y promoción del autocuidado en pacientes con insuficiencia renal crónica en tratamiento conservador. Método: estudio de revisión de alcance, con selección de documentos indexados en ocho bases de datos y dos catálogos de tesis y disertaciones. Además, se consultaron las listas de referencias de los estudios seleccionados. La selección y análisis de los estudios se realizó mediante el software Rayyan por medio investigación doble, independiente y ciega. Resultados: se encontraron 56 publicaciones elegibles y se seleccionaron diez para componer el estudio. Entre las intervenciones de teleenfermería se destacaron: aplicaciones para celulares, sitios web , plataforma digital, atención telefónica y teleconferencias. Conclusión: se evidenció que el uso de la Telesalud por parte de Enfermería es relevante para el sector de la salud, pero aún poco explorado en la literatura nacional e internacional, representando un vacío de conocimiento a ser llenado en futuras investigaciones. Estudios han demostrado que su implementación ayuda y apoya a los profesionales de la salud, brindando inferencias y orientaciones para una asistencia rápida, segura y eficaz, incluso a distancia. La teleenfermería se presenta como una estrategia capaz de promover la adherencia al tratamiento y al autocuidado en pacientes con insuficiencia renal crónica en tratamiento conservador.
Use of Telenursing in the conservative treatment of patients with chronic renal insufficiency: scoping review
Authors: Biancamano Aline de Oliveira , Camacho Alessandra Conceição Leite Funchal , Cortez Elaine Antunes , Menezes Harlon França de , Almeida Yasmin Saba de , Rocha Cristiele Costa da Matta
Published: October 2024

Objective: to map the evidence of the use of telenursing in adherence to treatment and promotion of self-care in patients with chronic renal insufficiency undergoing conservative treatment. Method: scoping review study, with selection of documents indexed in eight databases and two catalogs of theses and dissertations. Additionally, the reference lists of selected studies were consulted. Selection and analysis of studies were carried out using Rayyan software through double, independent and blind investigation. Results: 56 eligible publications were found and ten were selected to compose the study. The following stand out among telenursing interventions: cell phone applications, websites, digital platform, telephone support and teleconferencing. Conclusion: it was evident that the use of Telehealth by Nursing is relevant to the health sector, but still little explored in national and international literature, representing a gap in knowledge to be filled in future research. Studies have shown that its implementation helps and supports healthcare professionals, providing inferences and guidance for quick, safe and effective assistance, even remotely. Telenursing presents itself as a strategy capable of promoting adherence to treatment and self-care in patients with chronic renal insufficiency undergoing conservative treatment.
Usability of the “Systematic Review Support” computer system: a methodological study
Authors: Escaldelai Fernanda Martins Dias , Escaldelai Leandro , Bergamaschi Denise Pimentel
Published: October 2024

Objective: to evaluate the usability of the “Systematic Review Support” computer system. Method: methodological study involving 21 students who evaluated the computer system in a remote and synchronous usability test. Two activities were carried out, containing 21 tasks simulating the initial steps of a review study, proposals for eliminating duplicate references, selecting studies and resolving disagreements between evaluators. At the end, participants answered the System Usability Scale questionnaire. The measures used were: completion rate with assistance (effectiveness) and time to complete the task (efficiency). The data was described in a table using the mean, standard deviation, minimum and maximum values. Results: in a total of 21 tasks, the participants had an assisted completion rate of 9% and an average time of 55.1 minutes (the expected time being 60 minutes). The average score provided by the System Usability Scale instrument was 82.4 (considering a score from 0 to 100), median 85; minimum value 35 and maximum 97.5. Conclusion: the computer system has the effectiveness and efficiency parameters required of a computer review tool. It has a usability score of 82.4 on a scale of 0 to 100 assessed by the System Usability Scale instrument. The version presented incorporates the adjustments identified in the test in use.
Uso de smartphone por pessoas idosas no processo de envelhecimento saudável: uma teoria fundamentada nos dados
Authors: Gallo Adriana Martins , Araujo Juliane Pagliari , Baccon Wanessa Cristina , Marques Francielle Renata Danielli Martins , Salci Maria Aparecida , Carreira Lígia
Published: October 2024

Objetivo: compreender os sentimentos e reconhecimentos de pessoas idosas ao experienciarem o uso do smartphone no cotidiano, bem como as implicações no processo de envelhecimento saudável. Método: pesquisa qualitativa, utilizando Unified Theory of Acceptance and Use of Technology ; Senior Technology Acceptance & Adoption Model e o referencial metodológico Teoria Fundamentada nos Dados, na vertente Construtivista. Recrutou-se intencionalmente pessoas com 60 anos ou mais; usuários de smartphones ; participantes há seis meses ou mais de um projeto de extensão, sem comprometimento cognitivo, determinados por amostragem teórica. Um roteiro semiestruturado orientou a coleta de dados. A análise comparativa constante e concomitante seguiu os passos de codificação inicial e focalizada, com apoio de memorandos, até a saturação teórica. O diagrama de Sankey integrou a análise dos dados, utilizando o software Atlas.ti. Resultados: 37 participantes foram alocados em dois grupos amostrais. Apresenta-se a categoria “Experimentando a evolução tecnológica durante o processo de envelhecimento” e duas subcategorias: “Experimentando sentimentos ao envelhecer frente ao desenvolvimento tecnológico”; “Usando o smartphone e reconhecendo novas experiências”. Conclusão: ao experienciar o uso do smartphone , pessoas idosas compreendem e reconhecem a busca por competências digitais partindo de suas necessidades de utilidade e aplicabilidade das Tecnologias de Informação e Comunicação em seu cotidiano, integrando ao processo de envelhecimento saudável.
Exploring the metaverse in the education of healthcare students: A scoping review
Authors: Bernardes Andrea , Gardim Lucas , Araújo Agostinho A C , Jensen Rodrigo , Motta Raquel Acciarito , Almeida Denise Maria de , Lima Roberta Rubia de , Peres Heloísa Helena Ciqueto
Published: October 2024

Objective: to map the literature on the incorporation of the metaverse in the education of undergraduate healthcare students. Method: scoping review following the recommendations of the JBI and Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR), performed on Web of Science, Medical Literature Analysis and Retrieval System Online (MEDLINE) via PubMed, Embase, Scopus, Cumulative Index to Nursing and Allied Health (CINAHL), Latin American and Caribbean Health Sciences Literature (LILACS) and ProQuest. Results: a total of 23 records were included, published between 2020 and 2023, and developed in 10 countries. The metaverse allows the simulation of hypothetical cases, making education interactive and attractive. However, it faces limitations, including the possibility of depersonalizing students, concerns about data security and privacy, and the high cost of implementing and maintaining its infrastructure. Conclusion: the metaverse enables the development of clinical competencies that support the construction of students’ professional identity. However, it may not be equitable, as it requires resources and knowledge from educators to implement it, contributing to increasing inequality in the education of healthcare students.
Entrenamiento de los músculos del piso pélvico en hombres con incontinencia urinaria post prostatectomía: revisión de alcance
Authors: Santos Jackelline Evellin Moreira dos , Brasil Virginia Visconde , Azevedo Cissa , Izidoro Lívia Cristina de Resende , Batista Anna Julia Guimarães , Ferreira André Carlos Santos , Mata Luciana Regina Ferreira da
Published: October 2024

Objetivo: mapear los protocolos de ejercicios para los músculos pélvicos disponibles en la literatura para el tratamiento de la incontinencia urinaria post prostatectomía. Método: esta es una revisión de alcance realizada en seis bases de datos. La recuperación de información se realizó mediante un instrumento específico, que incluye: título, autoría, año de publicación, revista, objetivo, diseño del estudio y descripción del contenido de los protocolos. Resultados: se incluyeron 24 estudios en total, de los cuales se obtuvieron diferentes protocolos. Las recomendaciones más frecuentes fueron: tres sesiones por día, con una frecuencia de seis a 15 contracciones por sesión; realizar los ejercicios en posición acostada, sentada y de pie. Las orientaciones más citadas en los protocolos fueron las contracciones del esfínter anal y del músculo bulbocavernoso. Todos los protocolos siguieron el principio de contracción regular de los músculos del piso pélvico, pero no hubo consenso sobre el inicio del protocolo, la duración del tratamiento, el tiempo de contracción/relajación y la intensidad de la fuerza de contracción. Conclusión: se encontraron diferentes orientaciones en los protocolos de entrenamiento de los músculos del piso pélvico para la incontinencia urinaria post prostatectomía, fundamentalmente sobre el tiempo de contracción, tiempo de relajación, número de contracciones por sesión, posición de entrenamiento y tiempo de duración del protocolo. Se adoptaron diferentes conceptos para definir la continencia urinaria en los protocolos. Es necesario desarrollar guías consensuadas que definan claramente los parámetros de los protocolos de entrenamiento.
Availability of residents and preceptors for interprofessional practices: mixed methods study
Authors: Maffissoni André Lucas , Martini Jussara Gue , Lazzari Daniele Delacanal , Vendruscolo Carine , Sanes Marina da Silva , Bresolin Paula
Published: October 2024

Objective: to evaluate the level of availability of residents and preceptors for interprofessional practices. Method: mixed methods study of the concurrent triangulation type, carried out with residents and preceptors of a hospital Multiprofessional Residency in Health. Results: more than 90% (n=186) of participants are highly available for interprofessional practices. However, practices instituted during undergraduate studies and the professional profile of those involved, especially with regard to the lack of communication between professions and openness to dialogue, were indicated as difficulties in implementing interprofessionality in the scenario investigated, which may negatively influence the availability of residents and preceptors. Conclusion: although residents and preceptors have high availability for the development of interprofessionality, certain factors make its implementation difficult, hindering collaborative work.
Fishing for the gonadotropin releasing hormone from the genome of Salminus brasiliensis (Characiformes: Bryconidae)
Authors: Graciano R. C. D. , Oliveira R. S. , Yazbeck G. M.
Published: October 2024

Abstract The technological development of tools that enable the spawning of different native species is paramount to enable ex situ conservation initiatives, as well as providing means for commercial hatchery of threatened fish which, in turn, relieve fisheries pressure over wild stocks. Neotropical migratory freshwater fish depend on hormonal induction for spawning in hatcheries, through expensive methods of limited efficiency. Salminus brasiliensis is one of the largest Neotropical freshwater fish, a piscivorous top-predator, prized in angling, highly valued in the market, and appreciated in gastronomy. Teleost fish have either, two or three GnRH paralogous genes: GnRH1, GnRH2 and the GnRH3. The expression products of these paralogous isoforms consist of a larger prepro-GnRH polypeptide, which undergoes post-translational proteolytic processing to yield the active decapeptide hormone. There is increasing interest in characterizing and understanding these neuropeptides, because of its practical application in hatchery spawning. We present the characterization of GnRH1’s coding sequence for the prepro-GnRH1 polypeptide of S. brasiliensis. An annotation from a genomic assembly was used for searching for GnRH paralogues, based on data from anonymous predicted transcripts. The sequence retrieved for GnRH1 was then used as a query for searching the uncharacterized GnRH paralogues from full genomes of Characiformes deposited at NCBI. The S. brasiliensis GnRH1 gene sequence retrieved was targeted for PCR and submitted to Sanger sequencing, allowing for its confirmation. It spans 423 bp (exon 1: 128 bp; intron: 161 bp; and exon 2: 1134 bp), with open reading frames coding for 264 and 88 amino acids, respectively. The different variants retrieved for the prepro-GnRH (1, 2 and 3) from Characiformes genomes and deposited sequences from NCBI grouped in three distinct clades in a neighbor joining tree, each forming a monophyletic branch and with the S. brasiliensis sequences nested within the expected groups. Here we observed a variation at a proteolytic site (GKR→GRR), reported as highly conserved in vertebrates up to now, that can potentially alter the cleavage site and modify the peptide topology. This work has characterized, for the first time, the sequence of the GnRH1 coding for its prepro-GnRH peptide, for a member of the Charaficormes order. This will help to promote research and development of tools for broodstock spawning and environmental management of S. brasiliensis and related migratory fish.
Neusa Amato e suas contribuições para as pesquisas em raios cósmicos no Brasil
Authors: Santos Laura Sued Brandão , Silva Indianara
Published: October 2024

Este artigo investiga a trajetória e as contribuições de Neusa Amato para a física brasileira em diálogo com os estudos de gênero e ciência. Neusa Amato, uma das pioneiras na pesquisa com emulsões nucleares no Brasil, teve um papel fundamental na institucionalização da física no país, especialmente no estudo de raios cósmicos e física de partículas. Utilizando uma metodologia baseada em levantamento de literatura secundária, bem como uma entrevista concedida por Neusa ao Centro Brasileiro de Pesquisas Físicas (CBPF), construímos uma narrativa histórica que destaca a importância de suas publicações e sua liderança no Laboratório de Emulsões Nucleares do CBPF e na Colaboração Brasil-Japão (CBJ). A análise também enfoca os desafios enfrentados por Neusa como mulher cientista em um campo dominado por homens, sublinhando as barreiras de gênero que marcaram sua carreira. Este trabalho contribui para uma historiografia da ciência no Brasil ao trazer à luz a relevância das contribuições de Neusa Amato para a institucionalização da física brasileira.