bluuebunny/crossref_metadata_2025 huggingface dataset:
Pancreaticoduodenectomy in multivisceral surgeries: clinical experience of two institutions
Authors: Egorov V. I. , Kotelnikov A. G. , Patyutko Yu. I. , Podluzhny D. V. , Akhmetzyanov F. Sh. , Ruvinsky D. M. , Kudashkin N. E. , Polyakov A. N. , Kantieva D. M. , Bazin I. S.
Published: December 2024

Aim. To describe the experience of multivisceral surgeries involving pancreaticoduodenectomy for tumors of various localizations, performed in two Russian medical institutions.

Materials and methods. A retrospective study was conducted on the outcomes of 251 multivisceral surgeries with pancreaticoduodenectomy performed in two medical institutions from January 2011 to April 2024.

Results. Tumors of pancreatic head, duodenum and large papilla of duodenum were detected in 180 cases (71.7%); colorectal tumors in 36 cases (14.3%); gastric tumors in 24 cases (9.6%); extrahepatic bile duct and gallbladder tumors in 7 cases (2.8%); renal tumors in 3 cases (1.2%); retroperitoneal tumor in 1 case (0.4%). In 107 cases, the surgery was combined with liver resection, including hemihepatectomy in 7 cases. Pancreaticoduodenectomy was combined with colorectal resection in 95 cases. Despite the extreme variability in the extent of multivisceral surgeries with pancreaticoduodenectomy, the complication rate and mortality amounted to 65.7% and 7.2%, respectively.

Conclusion. The structure of multivisceral surgeries with pancreaticoduodenectomy appears to be extremely heterogeneous in terms of localization, tumor histogenesis, and the volume of surgical interventions. The frequency of postoperative complications and mortality indicates acceptable tolerability of such surgeries.
Modern strategies for the treatment and prevention of bleeding from gastric
Authors: Kotiv B. N. , Dzidzava I. I. , Dzhafarov A. A. , Bugaev S. A. , Soldatov S. A. , Alent’yev S. A. , Bartoshinskaya V. V. , Gusarova P. A.
Published: December 2024

Aim. To analyze the results of modern prevention and treatment strategies applied for bleeding from gastric varices in patients with portal hypertension syndrome.

Materials and methods. The study enrolled 276 patients with portal hypertension, including 187 cases of liver cirrhosis and 89 cases of extrahepatic portal hypertension. 24% of the patients with liver cirrhosis were classified as Child-Turcotte-Pugh Class A, 50% as Class B, and 26% as Class C. The portal vein thrombosis was confirmed in 80% of extrahepatic portal hypertension cases, while isolated splenic vein thrombosis was observed in 20%. Varices GOV1 (Sarin classification) were identified in 126 patients (45.7%), GOV2 in 110 patients (39.8%), and IGV-1 in 40 patients (14.5%). The following interventions were performed: endoscopic ligation, endoscopic sclerotherapy, endovascular techniques (transjugular intrahepatic portosystemic shunt, balloon-occluded retrograde transvenous obliteration), laparoscopic gastric devascularization, and distal splenorenal anastomosis.

Results. Following endoscopic procedures, recurrence of gastric varices was noted in 20% of cases, and bleeding occurred in 7%. The efficacy of endoscopic treatment amounted to 71%; endoscopic ligation for bleeding from GOV1 varices appeared effective in 94.4% of cases. Early recurrence of bleeding developed in 29.4% of patients. The efficacy of endoscopic sclerotherapy for bleeding from GOV2/IGV1 varices comprised 96.7% with early recurrence occurring in 12.9% of patients. The secondary prevention involved multiple endoscopic interventions that led to complete eradication of gastric varices in 34% of cases with recurrent bleeding noted in 9.3% of patients, while persistent recurrence of gastric varices was observed in 66%. A splenorenal anastomosis provided reliable prevention of recurrent bleedings. No shunt thrombosis or mortality was recorded; however, the incidence of post-shunt encephalopathy comprised 16.5%. Transjugular intrahepatic portosystemic shunt facilitated a significant reduction in portal pressure and the enlargement of esophageal and gastric varices. Post-shunt encephalopathy occurred in 48.6% of patients. In the long-term follow-up, a recurrence of esophagogastric bleeding was recorded in one patient. Laparoscopic azygoportal disconnection contributed to the regression of varices in the esophagus and stomach; however, a recurrence of gastric varices developed in 30% of cases and a recurrence of bleeding in 12.5%.

Conclusion. Current medicine obtains a sufficient arsenal of modern methods for the treatment and prevention of bleeding from gastric varices. The choice of treatment and prevention strategies for bleeding in portal hypertension necessitates a differentiated approach, taking into account the etiology and degree of disease decompensation.
Ontology of the subject’s identity in the philosophy of Emmanuel Levinas
Authors:   Lomonosov Moscow State University, Bulanov Stanislav M.
Published: December 2024

This study presents an ontological analysis of the conception of the subject’s identity proposed by Emmanuel Levinas. The topic appears to be relevant due to the interest of the humanities to the category of the subject’s identity increasing over past decades. The paper deals with Levinas’s criticism of the classical model of the subject’s identity, in which the subject is comprehended as selfsame. The study has found it to be related to Hegel’s interpretation of totality, which is understood as sublation of the other by the same, and also to Husserl’s phenomenology. The author notes a significant drawback of the classical conception of the identity of the subject — its incapacity to provide a final selfsameness of the subject, which results in the suppressing of otherness in the subject. The study analyzes Levinas’s attempt to present the face of the Other as an expression of the transcendental, which subverts totality and opens up a possibility of constructing an alternative model of the subject’s identity. Levinas’s conception of identity as responsibility is reconstructed, its ethical consequences are outlined. The article states that Levinas’s model of the subject’s identity is formed around the responsibility of the subject, which is understood simultaneously as responsibility of the subject to the Other for itself and responsibility of the subject to itself for the Other. The author concludes that Levinas’s conception is capable to ensure a balance in the subject between selfsameness and otherness through the idea of responsibility as the central category in constructing the model of the subject’s identity. The paper demonstrates that Levinas’s model of the subject’s identity not only contributes to resolving the problems created by the classical model but also appears to be its reliable alternative.
Creativity out of nothing and polyphony-2: Chekhov’s philosophical anthropology through the prism of ideas of Lev Shestov and Leonid Heifetz
Authors:   Lomonosov Moscow State University, Kon Vyacheslav A. , Markov Alexander V. ,   Russian State University for the Humanities
Published: December 2024

Lev Shestov’s essay Creativity Out of Nothing is relevant as an anthropological experience: the philosopher considers how creative self-realization is possible that each time points out the absence of the grounds for creation. Creation appears as a form of reflection on the primary situation of art for art’s sake: Chekhov’s social pathos only becomes radical when it returns to this primordial setting. This is why Shestov reads Chekhov in two ways: on the one hand, from the viewpoint of existential philosophy, where the very situation of being ejected into the world proves to be the primary motive and condition for creative work, the horizon of all conventions; on the other hand, from the perspective of irony, where the very preconditions of creation are defamiliarized. Shestov’s method allows us to introduce the term polyphony-2 for Chekhov’s work in order to distinguish it from Dostoevsky’s polyphony-1. In his TV film version of The Cherry Orchard (1976), Leonid Heifetz attempted to reunite the existential situation and irony, but within a performative effort aiming to show the transition from the ideals of the Soviet intelligentsia of the 1960s to the disappointments of the 1970s. The penetration of the Russian into the Soviet in film based on Chekhov is the permeation of discursivity into performativity: Heifetz sees Chekhov not as a creator of ambiguous dialogues, but as a master of discursive statements. Thereby, he continues Lev Shestov, but abandons his supra-historical paradoxalism, creating a kind of cult of the history of the past. Such an analysis of Chekhov’s legacy through a double prism allows us to clarify both the peculiarities of passéisme, the cult of the noble past, among Soviet intellectuals and the performative potential of Chekhov’s entire oeuvre (including not only his dramatic works), which may be in demand today.
The relationship between anxiety experiences and attention disorders in the digital age: a review of research
Authors:   Perm State University, Merzlyakov Dmitry E.
Published: December 2024

The article presents a review of studies on the impact of media content on an individual’s adaptive potential. It examines the relationship between anxiety levels and attention disorders in the context of digital reality. The influence of media content is analyzed through mechanisms such as media multitasking and media dependency. The literature analysis has revealed two patterns. First: media content consumption is linked to the experience of anxiety, which shapes selective attention to stimuli — individuals avoid information causing their anxiety. Due to this selectivity, individuals increasingly turn to subjectively approved content, ignoring negative materials, including news, which reduces their awareness. Second: individuals tend to incorporate approved content into their daily activities, for example, through combining work processes with watching videos. This reduces attention stability due to constant switching between different information sources. As a result, individuals shift their attention to negative information more often, which increases their anxiety. Thus, uncontrolled media consumption negatively affects an individual’s mental health and, in the long term, leads to symptoms of attention deficit hyperactivity disorder and the development of anxiety disorders. Therefore, the author emphasizes the importance of awareness and management of media consumption for maintaining mental health and enhancing an individual’s adaptive potential.
Tane Heterojenitesi ve Farklı Anaçların Papazkarası Üzüm Çeşidi Tane Özelliklerine Etkisi
Authors: Bahar Elman , Korkutal Ilknur , Erişken Semih
Published: December 2024

Deneme Kırklareli ili Pınarhisar ilçesinde İrem Çamlıca Bağcılık ve Şarapçılık Ltd. Şti. bağında yürütülmüştür. Bitkisel materyal olarak on yaşında olan; Papazkarası/1103P, Papazkarası/110R ve Papazkarası/420A aşı kombinasyonu omcaları seçilmiştir. Çalışmada farklı anaçlara aşılı Papazkarası üzüm çeşidi salkımlarından alınan tanelerin özellikleri belirlenmiştir. Diğer amaç ise tane heterojenitesinin tane özelliklerini nasıl etkilediğinin ortaya konmasıdır. Bu amaçla, hasat edilen salkımlardan alınan taneler boyutlarına göre sınıflanmıştır; ≤12 mm (B2); 12,01-14,00 mm (B3); 14,01-16,00 mm (B4); 16,01-18,00 mm (B5) ve ≥18 mm (B6). Ayrıca Kontrol (B1) boyut grubu toplam tane sayısının tane boyutlarına dağıtılmasıyla oluşturulmuştur. Tane özelliklerini ortaya koymak için; tane eni-boyu, tane yaş ve kuru ağırlığı, 100 tane ağırlığı, tane hacmi ve 100 tane hacmi kriterleri incelenmiştir. Ayrıca; tane özkütlesi, % kuru ağırlık, TKA/TH, şeker konsantrasyonu, tanede şeker miktarı, 1g tanede şeker miktarı ile verim belirlenmiştir. Sonuç olarak, düşük vigora sahip 420A anacının tane özellikleri açısından şaraplık çeşitlerde istenilen en düşük değerlere sahip olduğu; öte yandan tane özkütlesi, % kuru ağırlık ve TKA/TH değerlerinin de yüksek olması sebebiyle öne çıktığı belirlenmiştir. Tane boyutları açısından da en yüksek tane sayısının 12,01 mm ile 18,00 mm arasında yer alan boyut gruplarında olduğu saptanmıştır. Üzüm kalitesi açısından bu boyutlar arasındaki taneler, yüksek kaliteli olmamakla birlikte şarap üretimi için idealdir. Öte yandan B2 (≤12,00 mm) ve B6 (≥18,00 mm) boyut gruplarında istenilen tane sayısına erişilememiştir.
A New Water Mite Species (Acariformes, Hydrachnidia) for the Fauna of Türkiye
Authors: Boyacı Yunus Ömer , Kabadayı Yıldırım Sera Övgü
Published: December 2024

This study provides the first record and morphological description of the freshwater mite genus Tartarothyas Viets, 1934 and Tartarothyas micrommata Viets, 1934, from Aksu Stream in Isparta Province, Türkiye. The results of this study are expected to contribute significantly to a better understanding of the water tick fauna in Turkey. The findings emphasize the importance of comprehensive morphological reassessments and DNA analyses to better understand the species' evolutionary relationships.
Looking Back to Better Understand Today’s Education: A Review of The Project Method – The Use of the Purposeful Act in the Educative Process by William Heard Kilpatrick
Authors: Kozan Kadir
Published: December 2024

The Project Method – The Use of the Purposeful Act in the Educative Process by William Heard Kilpatrick is a very informative book or article, in the author’s words, providing some of the earliest insights into the concept of project and project-based learning. The author’s purpose is to attempt to explain the latent concept that is fundamental to the term project and claim that the underlying concept should be a part of the way in which we think about education. The reading is eye-opening since what it means by a project has certain features some of which are shared with other instructional approaches, thus suggesting a certain level of intertwined relationships among them and having an eclectic approach to project-based learning. For instance, according to the author, a learner’s making a dress or building a kite with a clear purpose and intention in a social context are projects that would remind the reader of constructionism or social constructionism. To this end, the reading gets the reader to question the origins of some instructional approaches and/or interconnections among them as well as their evolution over time. Finally, the reading also highlights the main features of a project: purposefulness, learners’ willingness to do it, and happening in a social environment or context. In other words, the reading provides strong lenses to view project-based learning, other relevant instructional approaches, and the interrelationships among them thus making looking back at the past or origins of instructional approaches a precious tool to better understand today’s educational context.
Análise de alternativas de sistemas de esgotamento sanitário para instituição de ensino e pesquisa em Rio Verde, Goiás
Authors: Alves Vanessa Petronília , Silva Júnior Edio Damásio da , Carmo Devaney Ribeiro do
Published: December 2024

Among basic sanitation services, sewage collection and treatment are important for health. It is the responsibility of collective enterprises to implement and maintain sewage systems within their property. The IFGoiano Rio Verde campus has had little updating of its sewage system over the years and has an old ceramic network and rudimentary pits which contain cracks and degradation and are possibly contaminating the soil. There are some possible alternatives for upgrading the campus sewage system. One of them is to establish a new collection network that will be interconnected to the city's existing public network. Another option would be to sector sewage into decentralized systems with the joint application of septic tanks and wetlands.  Therefore, this work aims to analyze the economic viability of each proposed alternative for adapting the campus's sewage system, and it was possible to observe that the centralized network is a system with greater user reliability, however, more costly, totaling a execution cost of R$ 1,849,549.35. The decentralized network is a system that is not yet as popular, but less expensive, totaling an execution cost of R$ 1,382,480.23. In addition to these values, the centralized network has an estimated operating and maintenance cost of R$ 13,187,424.57 over 20 years, which makes the choice for this alternative unfeasible, as the operating and maintenance costs of the decentralized network are of R$ 44,697.60.
Teaching on the Edge: TPACK and Professional Identity Formation in a Remote Island of Indonesia
Authors: Taopan Lita Liviani , Fitriati Sri Wuli , Mudjiyanto Januarius , Sakhiyya Zulfa
Published: December 2024

Becoming a teacher is a challenging decision for many individuals, as the teaching profession is inherently complex. Furthermore, the challenges increase significantly when one chooses to teach in rural areas. The study aims to explore the experiences of six novice English teachers from rural Indonesia on how TPACK framework has helped them shape their professional teacher identity. Using a narrative inquiry approach, data were collected through in-depth interviews and observations. The narratives were analysed based on the predetermined themes that covers novice English teachers’ career, their TPACK implementation, and how TPACK shape their professional identity. The analysis reveals that TPACK plays a significant role in the development of teacher identity, with each of its elements contributing significantly to different aspects of teaching. The findings indicate that a strong teacher identity emerges from a proportional understanding and effective implementation of the TPACK framework. Furthermore, the study highlighted the essential role of teacher education programs in providing pre-service teachers with comprehensive knowledge and experiences to foster identity formation. The relationship between the TPACK framework and teacher identity is found to be interconnected and complementary. Future research should explore the long-term impact of TPACK implementation on teaching practices and examine its effects in a more diverse and complex setting to obtain a broader understanding.
Systematic Literature Review: The Effectiveness of Technology-Assisted Project-Based English Language Learning
Authors: Rochimah Heni , Japar Muhammad , Solihatin Etin
Published: December 2024

The problem with learning English lies in the need for updated instructional methods. Project-based learning, a contemporary model suited for the 21st century, fosters collaboration to ignite students' enjoyment of learning. The increasing use of technology in learning is establishing a new effectiveness learning model. This research aims to determine the influence of technology-assisted and project-based learning (TPjBL) on English language acquisition, analyze factors that influence the TPjBL on English language learning, and analyze media used in implementing TPjBL in English language learning. The research methods involved a systematic literature review, analyzing 23 (twenty-three) articles selected through the PRISMA process from 2015 to 2023. The data analysis technique utilized a predetermined review protocol containing three main aspects, including bibliography, research details, as well as focus and content of the article. Based on the consequences of the analysis using protocol review, it was found that the positive influence of TPjBL on English learning was 91%, with influencing factors including student conditions, technology features, authentic projects, group communication and collaboration, teacher conditions, as well as the most widely used media of social media and web. These three parties can benefit from the results of this study. Teachers must be able to create good learning plans (project planning, technology selection), preliminary activities and appropriate assessment principles. For schools and governments, curriculum adjustments, technological facilities, such as computers, and the availability of internet access must be reviewed if determining to implement TPjBL in English learning.
The Effect of Metacognitive Awareness of Reading Strategies and Reading Comprehension Self-Efficacy Perception on Reading Motivation
Authors: Baki Yasemin
Published: December 2024

The aim of this study is to determine the impact of fifth grade students' reading strategies, metacognitive awareness, and reading comprehension self-efficacy perceptions on their motivation to read texts, and to determine how these variables predict each other and to what extent their explanation rates are. The research group of the study is identified by simple random sampling method, one of the random sampling methods; the participants are 304 middle school students from a school in a province in northern Türkiye. The collected data is analyzed in accordance with structural equation modelling. In the research, hypothesis models established based on the literature were tested and all models are found to be valid. Five of the twelve hypotheses created regarding the models were supported by the data, and the other seven hypotheses are rejected. In models related to text types, reading strategies have a direct and high impact on metacognitive awareness and self-efficacy perception in reading comprehension in all text types. On the other hand, the direct effect of text types on the effect of metacognitive awareness of reading strategies and self-efficacy perception of reading comprehension on reading motivation is insignificant. As a result of the research, it is determined that metacognitive awareness of reading strategies do not have a direct effect on reading motivation, while the perception of reading comprehension self-efficacy has a direct and high effect on reading motivation.
Tokenism Perception Scale: Validity and Reliability Study
Authors: Özdemir Tuncay Yavuz , Gürbüz Oğuz , Doğan Abdulvahap
Published: December 2024

Tokenism can be defined as the activity of opening the way for numerical minority individuals to become visible, in order to demonstrate the existence of a perception of diversity and inclusion in organizations and to help that organization appear tolerant or inclusive. The concept of tokenism; previously, emerged only from the disadvantages of being a woman, but with ongoing research, it has been determined that many different variables cause this perception within the organization. In this research, it was aimed to develop a valid and reliable measurement tool that can determine the level of teachers' perception of tokenism. In this research, an exploratory sequential design was used, combining both qualitative and quantitative research designs. The study group of the research consists of 304 teachers working in Malatya during the Exploratory Factor Analysis (EFA) phase and 306 teachers working in Elazig province during the Confirmatory Factor Analysis (CFA) phase. While creating the item pool, a literature review was conducted and the scale items were created based on this literature. These items were submitted to expert opinion to ensure content validity. As a result of EFA conducted to determine construct validity, a 3-factor structure consisting of 14 items was obtained. This structure was tested in a different sample group. As a result of CFA, it was determined that the fit values were at an acceptable level. In light of these data, it has been determined that the Tokenism Perception Scale is a valid and reliable measurement tool.
The Mediating Role of Digital Literacy between Lifelong Learning Tendency and 21st Century Skills
Authors: Yılmaz Fatih , Yılmaz Özelçi Serap , Çelebi Celalettin
Published: December 2024

The rapid growth of technology accompanied new requirements in all aspects of life. The constant flow of information and the irresistible rise of technology gave rise to 21st-century skills, digital literacy, and lifelong learning concepts which are all in the spotlight of several organizations, policymakers, and researchers. Due to the increasing accessibility of technology, people, each day, feel the need to adapt to this new pace of life. Thus, teachers not only should be aware of their students’ needs but also be equipped with the qualifications the current age entails. With this in mind, in this paper, the researchers studied the mediating role of digital literacy between teachers' lifelong learning tendency and their 21st-century skills. The sample consists of 273 randomly selected teachers. The researchers used three different multifactor data collection tools. In addition to the acceptable validity and reliability results, the findings indicate varying degrees of positive correlations among the factors of the data collection tools. The outputs also indicate that participants’ lifelong learning tendencies were at a low, but digital literacy and 21st-century skills were at a medium level. Moreover, while lifelong learning tendency directly affects 21st-century skills, ethics and responsibility act as a mediator between lifelong learning tendency and 21st-century skills.
hUC-MSC extracellular vesicles protect against hypoxic-ischemic brain injury by promoting NLRP3 ubiquitination
Authors: Xiao Shanshan , Lv Ying , Hou Xuejing , Qu Shuqiang
Published: December 2024

Hypoxic-ischemic brain injury (HIBD) is a major cause of neonatal mortality and long-term neurological deficits, with limited treatment options. Extracellular vesicles (EVs) from human umbilical cord mesenchymal stem cells (hUC-MSC-EVs) have shown promise in neuroprotection, but the mechanisms remain unclear. This study explores how hUC-MSC-EVs protect neonatal rats from HIBD. hUC-MSC-EVs were isolated, characterized, and administered to neonatal rats subjected to HIBD. Behavioral reflexes and brain infarction were assessed, along with cellular and molecular analyses of hippocampal tissue. An in vitro oxygen–glucose deprivation/reoxygenation (OGD/R) model was used to simulate ischemic conditions in rat primary microglia. Results demonstrated that hUC-MSC-EVs significantly improved neurological outcomes, reduced brain infarction, and decreased microglial activation and pyroptosis. These effects were linked to the inhibition of NLRP3 inflammasome activation and enhanced ubiquitination via the protein kinase A (PKA) pathway. Blocking PKA partially reversed these protective effects. Here we highlight that hUC-MSC-EVs provide neuroprotection by regulating the NLRP3 inflammasome, offering a potential therapeutic strategy for HIBD. These findings expand the understanding of EV-mediated neuroprotection and suggest broader applications for ischemia-related conditions, with potential for clinical translation.
The Impact of Systemic Conditions on the Durability and Success of Dental Implants
Authors: Ilan Hudson Gomes de Santana , Anderson Jara Ferreira , Camila Coêlho Guimarães , Erick Andres Alpaca Zevallos , Paola de Cassia Spessato Schwerz , Karolayne Dutra Félix , Maria Eduarda Batista Henriques , Dárcio Brito da Cunha , Darfany Talita Brito Santos , Mayara Rebeca Martins Viana , Felipe Germóglio C Macêdo
Published: December 2024

Objective: To critically analyze the literature on the impact of diabetes and autoimmune diseases on the success and durability of dental implants, discussing strategies aimed at improving clinical management for these patients.
Background: Systemic conditions such as diabetes mellitus and autoimmune diseases pose significant challenges in implant dentistry, influencing osseointegration and the long-term success of implants. Addressing these challenges is critical to ensuring optimal patient outcomes.
Materials and methods: A search was conducted in PubMed, Scielo, and ScienceDirect, focusing on articles published in the last ten years that address the implications of systemic conditions on dental implants. Relevant clinical articles, systematic reviews, and meta-analyses were selected.
Results and discussion: Uncontrolled diabetic patients showed a higher risk of complications, but glycemic control and bioactive implant surfaces mitigate these risks. Autoimmune patients face increased infection risks and impaired healing; strategies such as drug dosage adjustments and biomaterials improve outcomes. A multidisciplinary approach is essential to personalize treatment.
Conclusion: Systemic conditions require personalized approaches in implant dentistry. Advances in biomaterials and evidence-based practices offer promising prospects, but further studies are needed to consolidate these approaches.
Hyphascope: Do-it-yourself assembly and application of an imaging device for hyphae in soil v1
Authors: Schaefer Holger
Published: December 2024

This protocol describes the do-it-yourself assembly and application of a low-cost high-resolution imaging device for hyphae in soil, called Hyphascope. The imaging device's design was adopted froma 3D printer, with a digital microscope camera(DMC) replacing the filament extruder. The application of the imaging device yields soil profile images at an imaging resolution of up to 0.52 μm px-1 (49000 dpi) within an observable volume of 70 × 210 × 1.5 mm. Repeated imaging of a soil profile following the protocol enables researchers to observe and quantify changes in the amount, distribution, and morphology of hyphae in soil.
Trending Themes on the Nature of Science in Science Education: A Bibliometric Analysis with VOSviewer
Authors: Kara Serpil
Published: December 2024

This study aimed to identify themes that indicate trends in the nature of science (NoS) in science education. The Web of Science (WoS) database was used for this purpose. A bibliometric approach was adopted, and the VOSviewer software was used to identify and systematically map research trends in the field of scientific innovation and to identify intellectual relationships in this network. In this context, the study covered the years 2013-2023. The categories “Education & Educational Research” and “Education Scientific Disciplines” were selected in the WoS database, and only article-type studies were included by excluding other publication categories obtained in the breakdown of the results. Finally, 263 articles were analyzed . According to the findings, the “Education Educational Research” WoS category is at the forefront. The publications made according to the years show alternating trends of increase and decrease. Lederman, N.G. is the author with the highest number of citations. Erduran, S. is the author with the highest number of studies and the highest total link strength. The majority of publications were in the journal “Research In Science Education.” The words “scientific literacy” and “history of science” were used most frequently after “nature of science” and “science education” among the keywords. The most frequently repeated words in the abstracts of the articles were "questionnaire" and "interview". Finally, the countries ranked in the top three in terms of total link strength and the most cited countries were the USA, England, and Türkiye, respectively.
A Research on Transformation Geometry: Answered and Unanswered Questions
Authors: Akarsu Murat , İler Kübra
Published: December 2024

This study synthesizes the current state of knowledge in geometric transformation research and suggests directions for future study. Specifically, we address the following five questions:
(1) What is geometric transformation?
(2) Why is geometric transformation important in school mathematics?
(3) What do we know about understanding geometric transformation?
(4) How can technology be used in geometric transformation activities?
(5) How are geometric transformation activities included in mathematics textbooks?
Each of these questions presents a fertile research area within the realm of geometric transformations. Following an overview of the existing knowledge in this domain, we proceed to examine, for each question, related unanswered issues that warrant additional consideration from the research community.
ASSERTIVENESS IN GIFTED PERSONAL RESOURCES SYSTEM IN DIFFICULT LIFE SITUATIONS
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Korolov D. K.
Published: December 2024

Difficult life situations shift the emphasis from creativity to adaptation, create a threat of giftedness wasting. Gifted individuals struggle with these situations using personal resources conceptualized as psychological resilience, hardiness, ability to recover, ego strength, self-efficacy, coping strategies, assertiveness. The first three concepts are descriptive and partially overlapping, but they do not reveal the ultimate sources and mechanisms of gifted people’s adverse life situations surviving. Ego strength, self-efficacy, productive coping strategies, assertiveness are intrinsically connected with the giftedness psychological structure and personality dynamics what developed by such people to overcome obstacles in realizing their potential.
There is complex relationship between assertiveness and giftedness. Communicative assertiveness can be considered as a tool for gifted people to promote their achievements, to ensure social recognition of the creative activity products. In other case insufficient assertiveness prevents recognition, does not allow a person to be considered as a realized gifted. It is possible what communicative assertiveness have unequal weight in giftedness different types. It may be that assertiveness is more deeply or somewhat in other forms integrated into the psychological structure of social and athletic giftedness.
Another facet of assertiveness – life assertiveness what maintains one’s own value regulation of activity and social interaction in which giftedness and talent manifest, develop, and gain recognition. In this way, assertiveness allows not to mask giftedness, not to stop its development.
Ulusal Kurtuluş Ordusu, Kolombiya’da Barışın Tesisi ve Sürdürülebilirliği
Authors: Ağkaya Onur
Published: December 2024

Kolombiya’daki iç savaş 60 yıldır süregitmektedir. Günümüz itibariyle savaşan gruplar arasında, Latin Amerika’nın aktif en eski gerilla örgütü Ejército de Liberación Nacional (ELN-Ulusal Kurtuluş Ordusu) bulunmaktadır. ELN, Kolombiya’daki birçok gerilla örgütünden farklılıklar arz eden bir oluşumdur. Bu çalışmada, öncelikli olarak ELN’nin, diğer örgütlerden farklılıklarının Kolombiya’da barış süreçlerini etkileyip etkilemeyeceği araştırma sorusuna yanıt aranmaktadır. Bu soruya yanıt verilebilmesi için, ELN’nin ortaya çıkışından bu yana tarihsel gelişimi, yapısı ve eylem repertuarı ele alınmakta ve Kolombiya’da barışın tesisine ve muhtemel geleceğine dair bir analiz sunulmaktadır. Araştırma sorusuna bağlı olarak, metodolojik olarak tarihsel-sosyolojik yorumlayıcı bir perspektifin benimsendiği çalışma, ELN ve Kolombiya örneklerini ele alarak Türkiye’de yapılan çatışma çözümü ve barış çalışmalarına katkı sağlamayı hedeflemektedir. Bu doğrultuda, yapılan analiz sonucunda, ELN’nin farklı bir yapı olduğu, bu örgütle müzakerelerin diğer gerilla örgütlerinden farklı bir şekilde daha kapsayıcı ajanda ve yaklaşımı gerektirdiği savunulmaktadır. Son olarak, çalışmada ELN’nin silah bırakmayı kabul etse bile Kolombiya’da barışın en azından kısa vadede ulaşılabilir ve sürdürülebilirlikten uzak olduğu öne sürülmektedir.
Green Synthesıs Of Cosmetıc Soaps Obtaıned From Laurel Nobılıs
Authors: Yağmur Hatice , Baykara Kübra , Sönmez Seyithan
Published: December 2024

In this study, Laurel nobilis oil was obtained from Laurel nobilis fruits. Qualitative analysis of Laurel fixed oil was performed by GC-MS. Additionally, saponification value (SV), acid value (AV), free fatty acid value (% FFA) and peroxide value (PV) values of bay Laurel oil were determined as 140.0 mg KOH/g, 26.5 mg KOH/g, 13.25 mg KOH/g, and 10.28 meq O2/kg, respectively. Activated carbon was obtained as a result of carbonization of the Laurel fruit seeds, which were waste as a result of oil extraction, at 500 oC. Activated carbon was characterized by FT-IR, BET, SEM and TGA. Soap is made of different fatty acid salts, either sodium or potassium. The obtained Laurel fruit oil and activated carbon were used in the preparation of solid soaps with peeling effect by the cold process method. pH, foam test, total alkaline test, and total fatty matter determination (TFM) of the prepared soaps were determined. Thus, the synthesis of activated carbon with peeling effect, which has good cleaning and foaming properties, was carried out.
Micromorphology of the proboscis sensilla of Maniola jurtina (Linnaeus, 1758) (Nymphalidae: Satyrinae)
Authors: Seven Çalışkan Selma , Mengi Yağmur , Candan Selami
Published: December 2024

Lepidoptera is the most suitable insect order to comprehend the connections between nutrition and mouthparts. The proboscis, which is typically tightly coiled between the labial palps, is a flexible organ used by most adult butterflies for extracting flower nectar and other liquids. We examined the proboscis structure and sensilla of Maniola jurtina Linn. by scanning electron microscope (SEM) in order to contribute to the relationship between food selection and proboscis structure in Satyrinae Sensilla chaetica (s. trichodea) of various lengths is the most common species along the proboscis. Sensilla styloconica is of pluricarinate type. It is densely located only in the distal region and is in rows. It has a long quill with 6 ribs (flat protrusions) and a relatively short nail. In the study, sensilla lengths were compared with the sensilla lengths of some other lepidopteran species.
Optimization of tillage roller parameters based on field research results
Authors: Proshkin Vyacheslav E. , Kurdyumov Vladimir I. , Bogatsky Roman V. , Proshkin Evgeny N.
Published: December 2024

BACKGROUND: Rolling, as a technology used after sowing, is widely used in agriculture in our country. The study of existing methods of surface tillage has revealed that one of the main components of these methods of operations is rolling, which improves the contact of seeds with the soil and positively affects the germination and subsequent development of crops.
OBJECTIVE: Improvement of the quality of surface tillage based on the development of a highly efficient spring-wave roller, which meets the agriculture requirements, ensures reduction of operating costs and increase of crop yields.
METHODS: A new design of the tillage roller capable of rolling the soil in compliance with agrotechnical requirements is proposed.
RESULTS: As a measure that determines the effectiveness of soil compaction during sowing with subsequent rolling by tillage rollers during the research, the kd density coefficient, which evaluates the quality of soil rolling relative to the reference density values set by agricultural requirements, was used.
Based on the obtained graphical interpretations of the models, it was determined that the best rolling quality is achieved at the velocity of the developed tillage roller in the range from 10.75 km/h to 25 km/h, two additional springs at the compactor and a ballast weight of 35...45 kg, which ensures the specific pressure of the spring-wave roller on soil of 1450,4...1515,7 N/m. At the same time, the kd values range from 0.875 to 0.9, which is 20% of the entire response surface.
CONCLUSIONS: As a result of the research, it was revealed that the proposed tillage roller ensures the best quality of soil rolling. The maximal value of the kd of soil equals to 0.9 and is achieved when treated with a tillage roller at a unit velocity of v = 11 km/h, a specific pressure on the soil of 1450.4 N/m and two additional springs at the compactor (C = 2 pcs.). This kd value is 30.4% higher compared to the density coefficient value achieved using the most common tillage rollers and 40.6% higher compared to a smooth water-filling roller.
Simulation of operating modes of electric power storage devices in AC traction power supply systems
Authors: Bakanova Elena I. , Nezevak Vladislav L. , Sidorov Oleg A.
Published: December 2024

Aim. Improving the efficiency of AC traction power supply systems. Solving challenges in testing technical and technological solutions using simulation modeling of their operating modes.
Methods and Materials. The research is based on a simulation model designed to test algorithms for regulating the operation of electric power storage devices within the traction power supply system. The tasks are solved using the following methods: system method, analytical method, and statistical modeling method.
Results. The proposed simulation model enabled the testing of an algorithm regulating an electric power storage device. The simulation provided results for active power regulation using the voltage levels in the contact network. The results included calculated oscillograms and voltages, along with their effective values for both charge and discharge modes.
Conclusion. The results obtained can be used to compare the effectiveness of different methods for regulating electric power storage devices in AC traction power supply systems.
Hemorrhagic bullous pemphigoid developing after linagliptin
Authors: Şimşek Salih Denis , Derviş Mert Adnan , Polat Mustafa , Zortuk Ökkeş
Published: December 2024

Linagliptin, a dipeptidyl peptidase IV inhibitor used to treat diabetes mellitus, has been associated with increased blood urea levels, increased lipase levels, arthralgia, dermatological reactions, heart failure and hypersensitivity reactions. A 68-year-old female patient presented to the emergency department with pruritic, raised, and hemorrhagic bullous eruptions on the skin. The patient's medical history included diabetes mellitus, hypertension and renal failure, and it was noted that she had started linagliptin therapy three weeks previously. The patient's complete blood count and biochemistry were unremarkable. Physical examination revealed fluid-filled lesions on the neck, back of the neck, trunk and both thighs. Examination of the oral and genital mucosa was normal. The patient had erosive haemorrhagic bullae and the Nikolsky sign was negative. After consultation with the dermatology department, a skin biopsy was planned, and after consultation with the internal medicine department, it was suggested that the current clinical condition was linagliptin-dependent and discontinuation of the medication was recommended. Bullous lesions are often associated with autoimmune etiologies and are observed between two weeks and five months. However, in subepidermal cases, the prognosis of haemorrhagic clinical features is more fatal and morbid compared to non-haemorrhagic ones. Various dermatological symptoms and bullous pemphigus have been reported in the literature following the use of linagliptin, whereas our case was a haemorrhagic bullous pemphigus.
Coffin-Lowry syndrome: two novel variants in RPS6KA3 gene
Authors: Karaer Derya , Durak Taner , Karaer Kadri
Published: December 2024

We present two novel mutations of RPS6KA3 in two Turkish boys with CLS. As reported in previous publications, growth and developmental delay and phenotypic appearance were typical in our cases.
Long-term outcomes of the patients with Cushing syndrome after endocrine remission
Authors: Akkuş Gamze , Aksoydan Ülcaz Perihan , Odabaş Fulya , Şengöz Coşkun Nur Sinem , Tetiker Bekir Tamer , Sert Murat
Published: December 2024

Purpose: The study aimed to evaluate metabolic parameters and bone density measurements during the active phase and after long-term remission, as well as to present long-term follow-up results of patients with Cushing Syndrome.
Materials and Methods: In 20 patients with Cushing Syndrome, weight, waist circumference, fasting plasma glucose, lipid parameters, blood pressure and bone mineral density were evaluated during the active disease and after endocrine remission.
Results: All patients were female, premenopausal with mean age of 35±9.5 (range 27-45). During the long-term follow-up (median 60 months), weight (87.6±21.2 vs 71.1±18.8) and waist circumference (98.02±11.5,) were decreased significantly compared to baseline measurements. While total cholesterol and triglyceride values were similar between before and after remission, LDL cholesterol (143.6±35.8 vs 127.7±37.06) was decreased significantly in all patients. During the hormonal remission, 63.6% of patients’ antihypertensive medication was discontinued. Bone mineral density in lumbar spine was increased compared to the baseline values of all patients.
Conclusion: Metabolic parameters and bone status were improved during the long-term follow-up time in patients with Cushing syndrome. Age, gender and duration of hypercortisolism or following time can influence the recovery of these comorbidities.
Association between aspirin resistance and indices of inflammation and platelet activity in patients with acute coronary syndrome
Authors: Aksoy Fatih , Bağcı Ali , Savran Mehtap , Aşçı Halil , Altınbaş Ahmet
Published: December 2024

Purpose: Aspirin resistance (AR) has been linked to increased cardiovascular morbidity and mortality in patients with acute coronary syndrome (ACS). Both ACS and AR have also been associated with enhanced platelet activity and inflammatory responses. This study aimed to evaluate the power of the levels of uric acid (UA), non-high-density lipoprotein (non-HDL) cholesterol, high-sensitivity C-reactive protein (Hs-CRP), and gamma-glutamyltransferase (GGT) and the mean platelet volume (MPV), to predict AR in patients with ACS.
Materials and Methods: This study included543 patients with ACS. AR was identified by whole blood aggregometry. Predictors of AR were determined through multivariate regression analyses and the receiver operating characteristic (ROC) curve analysis.
Results: The levels of UA, GGT, non-HDL cholesterol, MPV, and Hs-CRP were significantly higher in patients with AR compared to those without AR (5.6±1.5 vs.6.8±3.1, 20 vs 34 (median), 162.3±43.2 vs. 143.2±37.1, 8.2 ±0.9 vs. 8.9 ±1.1, 5.0 vs 14.7 (median)). A multivariate regression analysis identified MPV, UA, Hs-CRP and presence of clopidogrel resistance as independent predictors of AR.
Conclusion: In patients with ACS, AR was found to be associated with elevated platelet activity and inflammation, suggesting that these factors might contribute to the development of AR or might be underlying mechanisms of AR. These findings highlight potential benefit of a routine workup to assess the oxidative status, inflammation, and thrombogenicity that may help risk stratification and treatment decision-making in clinical Practice, in patients with AR.
Hispidulin can improve lipid parameters in the HepG2 cell line with metabolic dysfunction-associated steatotic liver disease
Authors: Aslan Bircan , Kaplan Davut Sinan , Ulusal Hasan , Tarakçıoğlu Mehmet
Published: December 2024

Purpose: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a significant health issue. Although its pathogenesis remains unclear, insulin resistance, steatosis, and inflammation play crucial roles. Research on alternative treatment agents is ongoing. This is the first study to investigate the effect of hispidulin, a flavonoid, in a MASLD model.
Materials and Methods: Non-toxic concentrations of hispidulin and oleic acid were determined using the MTT cytotoxicity assay. Cells were first treated with hispidulin, followed by the addition of oleic acid two hours later. The cells were incubated for 24 hours to induce lipolysis. The intracellular lipids were demonstrated both qualitatively and quantitatively using Oil Red O staining. Triglyceride and total cholesterol levels, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, and adenosine monophosphate-activated protein kinase (AMPK) and sirtuin 1 (SIRT1) levels were measured.
Results: Hispidulin at 40 µM significantly reduced triglyceride levels by 67%, total cholesterol levels by 53%, ALT levels by 66%, and AST levels by 36%. However, no increase in AMPK or SIRT1 levels was observed compared to the model group.
Conclusion: Hispidulin can reduce cellular lipid accumulation, improve lipid parameters, and lower aminotransferase enzyme levels in MASLD. However, this effect may not occur via the AMPK-SIRT1 pathway but rather through other mechanisms. Further studies are needed to elucidate the mechanisms of hispidulin's action in MASLD.