bluuebunny/crossref_metadata_2025 huggingface dataset:
Curcumin alleviates osteoarthritis in mice by suppressing osteoclastogenesis in subchondral bone via inhibiting NF-κB/JNK signaling pathway
Authors: Ding Dong , Liu Guoqiang , Yan Jiangbo , Zhang Qingyu , Meng Fanding , Wang Limei
Published: September 2024

This study explored the mechanism of curcumin (CUR) suppressing osteoclastogenesis and evaluated its effects on osteoarthritis (OA) mouse. Bone marrow-derived macrophages were isolated as osteoclast precursors. In the presence or absence of CUR, cell proliferation was detected by CCK-8, osteoclastogenesis was detected by tartrate-resistant acid phosphatase (TRAP) staining, F-actin rings formation was detected by immunofluorescence, bone resorption was detected by bone slices, IκBα, nuclear factor kappa-B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways were detected using western blot, osteoclastogenesis-related gens were measured using quantitative polymerase chain reaction. A knee OA mouse model was designed by destabilizing the medial meniscus (DMM). Thirty-six male mice were divided into sham+vehicle, OA+vehicle, and OA+CUR groups. Mice were administered with or without CUR at 25 mg/kg/d from the first post-operative day until sacrifice. After 4 and 8 weeks of OA induction, micro-computed tomography was performed to analyze microstructure changes in subchondral bone, hematoxylin and eosin staining was performed to calculate the thickness of the calcified and hyaline cartilage layers, toluidine blue O staining was performed to assess the degenerated cartilage, TRAP-stained osteoclasts were counted, and NF-κB, phosphorylated Jun N-terminal Kinases (p-JNK), and receptor activator of nuclear factor κB ligand (RANKL) were detected using immunohistochemistry. CUR suppressed osteoclastogenesis and bone resorption without cytotoxicity. CUR restrained RANKL-induced activation of NF-κB, p-JNK and up-regulation of osteoclastogenesis-related genes. CUR delayed cartilage degeneration by suppressing osteoclastogenesis and bone resorption in early OA. The mechanism of CUR inhibiting osteoclastogenesis might be associated with NF-κB/JNK signaling pathway, indicating a novel strategy for OA treatment.
The Effect of Glibenclamide on the Functional Activity of КATP Channels of Cerebral Arteries in Rats with Streptozotocin Diabetes Mellitus
Authors: Sokolova I. B. , Lobov G. I.
Published: September 2024

BACKGROUND: In the treatment of diabetes mellitus (DM) for a persistent reduction in blood glucose levels it was widely used glibenclamide — a KATP channels blocker. However, its effects on cerebral circulation have been studied very little. A decrease in the functional activity of KATP channels due to their blocking by glibenclamide against the background of developed endothelial dysfunction may lead to impaired cerebral circulation (especially at the microcirculatory level) and promote remodeling of the vascular network.

AIM: To evaluate the effect of glibenclamide on the reactivity of cerebral arteries in rats with streptozotocin-induced diabetes mellitus (STZ-T2DM).

TASKS: 1. To study changes in the functional state of KATP channels of pial arteries in STZ-T2DM. 2. To evaluate the effect of glibenclamide on the participation of KATP channels in the formation of basal tone and endothelium-dependent dilatation of pial arteries.

MATERIALS AND METHODS: The study was performed on 54 male Sprague Dawley rats. Streptozotocin-induced diabetes mellitus (STZ-T2DM) was modeled by keeping animals on a high-fat diet and administering streptozocin (35 mg/kg). Using an installation for intravital study of pial vessels reactivity, 3 months from the beginning of the experiment, the diameter of the arteries was measured when the brain surface was irrigated with Krebs-Henseleit solution, acetylcholine, glibenclamide, pinacidil and acetylcholine against the background of the action of glibenclamide or pinacidil.

RESULTS: With modeling STZ-T2DM, rats developed glucose tolerance and insulin resistance. Compared to control animals, body weight was 1,3 times higher, the percentage of visceral fat was 3 times higher, and the blood glucose level was 3,2 times higher. It was shown that in STZ-T2DM the number of pial artery constrictions under the action of glibenclamide decreased by 1,3 — 1,9 times compared to intact rats. Glibenclamide did not block endothelium-dependent dilation.

CONCLUSION: In rats with streptozotocin diabetes, KATP channels take part in the formation of the basal tone of the pial arteries, but the contribution of these channels is reduced on average by 1.5 times compared to healthy rats.

The use of glibenclamide in STZ-T2DM does not affect endothelium-dependent dilatation of cerebral arteries.
Erratum: Insufficiency/deficiency of vitamin B12 in patients in the endocrinological practice (Diabetes mellitus. 2024;27(3). doi: 10.14341/DM13181)
Authors: Mokrysheva N. G. , Shestakova M. V. , Ametov A. S. , Antsiferov M. B. , Bakulin I. G. , Vavilova T. V. , Galstyan G. R. , Demidova T. Y. , Dzgoeva F. K. , Karonova T. L. , Lukina E. А. , Mkrtumyan A. M. , Petunina N. А. , Ponomaryov R. V. , Suponeva N. A. , Sukhareva O. Y. , Shamkhalova M. S.
Published: September 2024

An erratum on « Insufficiency/deficiency of vitamin B12 in patients in the endocrinological practice» by Natalya G. Mokrysheva, Marina V. Shestakova, Alexander S. Ametov, Mikhail B. Antsiferov, Igor G. Bakulin, Tatiana V. Vavilova, Gagik R. Galstyan, Tatiana Y. Demidova, Fatima K. Dzgoeva, Tatiana L. Karonova, Elena A. Lukina, Ashot M. Mkrtumyan, Rodion V. Ponomaryov, Natalia A. Suponeva, Olga Y. Sukhareva, Minara S. Shamkhalova (2024). Diabetes mellitus. 27(3). doi: 10.14341/DM13181

An error was made in the list of authors: Nina A. Petunina was not indicated as author of this article. The correct list of authors: Natalya G. Mokrysheva, Marina V. Shestakova, Alexander S. Ametov, Mikhail B. Antsiferov, Igor G. Bakulin, Tatiana V. Vavilova, Gagik R. Galstyan, Tatiana Y. Demidova, Fatima K. Dzgoeva, Tatiana L. Karonova, Elena A. Lukina, Ashot M. Mkrtumyan, Nina A. Petunina, Rodion V. Ponomaryov, Natalia A. Suponeva, Olga Y. Sukhareva, Minara S. Shamkhalova.

The identifier in the ORCID system for F.K. Dzgoeva was also indicated incorrectly. The correct link is: https://orcid.org/0000-0002-0533-7652.

The editorial board apologize for this error and state that this does not change the scientific conclusions of the article in any way.

The original article has been updated.
SMED-TLX-1 (NR2E1) Is Critical for Tissue and Body Plan Maintenance in Schmidtea mediterranea in Fasting/Feeding Cycles
Authors: Raška O. , Kostrouchová V. , Behenský F. , Yilma P. , Saudek V. , Kostrouch Z. , Kostrouchová Marta
Published: September 2024

Nuclear receptors (NRs), or nuclear hormone receptors (NHRs), are transcription factors that regulate development and metabolism of most if not all animal species. Their regulatory networks include conserved mechanisms that are shared in-between species as well as mechanisms that are restricted to certain phyla or even species. In search for conserved members of the NHR family in Schmidtea mediterranea, we identified a molecular signature of a class of NRs, NR2E1, in the S. mediterranea genome and cloned its complete cDNA coding sequence. The derived amino acid sequence shows a high degree of conservation of both DNA-binding domain and ligand-binding domain and a remarkably high homology to vertebrate NR2E1 and C. elegans NHR-67. Quantitative PCR detected approximately ten-fold higher expression of Smed-tlx-1 in the proximal part of the head compared to the tail region. The expression of Smed-tlx-1 is higher during fed state than during fasting. Smed-tlx-1 down-regulation by RNA interference affects the ability of the animals to maintain body plan and induces defects of brain, eyes and body shape during fasting and re-growing cycles. These results suggest that SMED-TLX-1 is critical for tissue and body plan maintenance in planaria.
Role of Transplanted Bone Marrow Cells in Response to Skeletal Muscle Injury
Authors: Čížková Dana , Vávrová J. , Mičuda S. , Filip S. , Brčáková E. , Brůčková L. , Mokrý J.
Published: September 2024

The recently discovered capacity of bone marrow cells (BMCs) to contribute to injury-induced skeletal muscle regeneration has brought new possibilities in the treatment of skeletal muscle diseases. However, a suitable method of BMC transplantation usable for such therapy has to be established. In this work, recipient mice were intramuscularly injected with cardiotoxin, then whole-body lethally irradiated to eradicate satellite cells in their injured tibialis anterior (TA) muscles and to suppress haematopoiesis, and subsequently intravenously transplanted with lacZ+ BMCs with the aim to investigate the role of exogenous BMCs in response to skeletal muscle injury. Seven to 33 days after grafting, recipient TA muscles were examined to detect donor-derived X-gal+ cells and analysed by quantitative PCR. In injured recipients’ muscles, X-gal positivity was identified 14 and 33 days after grafting in some infiltrating neutrophils and macrophages, infrequently in fibroblasts of endomysium, and in many large multinucleated cells (devoid of myogenic markers desmin and nestin) resembling foreign body giant cells situated in the vicinity of necrotic muscle fibres. qPCR confirmed the presence of transplanted lacZ+ BMCs in injured recipients’ muscles. Our results proved the ability of intravenously transplanted adult BMCs to settle in injured muscles and generate blood cells that infiltrated endomysium and took part in the cleaning reaction. After inhibition of endogenous myogenesis, BMCs were not able to participate in formation of new muscle fibres due to persisting necrosis of degenerated muscle fibres. Instead, BMCs attempted to resorb necrotic structures, which confirmed the indispensable role of bone marrow-derived macrophages in skeletal muscle regeneration.
Hepcidin Expression in the Liver of Mice with Implanted Tumour Reacts to Iron Deficiency, Inflammation and Erythropoietin Administration
Authors: Vokurka Martin , Krijt J. , Vávrová J. , Nečas E.
Published: September 2024

Cancer is known to be an important cause of anaemia due to several factors including iron deficiency and inflammation. Hepcidin, a key regulator of iron metabolism, is up-regulated by iron and inflammatory stimuli such as interleukin 6, and decreased by iron deficiency, enhanced erythropoiesis and hypoxia. It is supposed to play a crucial role in changes of iron metabolism in anaemia of chronic disease, which is characterized by sequestering iron in macrophages and decreasing its availability for red blood cell production. To study the effect of tumour growth on hepcidin expression, we implanted human melanoma cells into mice and studied the changes of the amount of liver hepcidin mRNA by real-time PCR. We observed development of anaemia, which correlated with the size of the tumour. Hepcidin expression significantly decreased with the anaemia development, but in late stages we observed an increase of its expression together with an increase of mRNA for interleukin 6. However, the increase of hepcidin expression could be inhibited by exogenous erythropoietin administration. In our model of tumour growth, hepcidin expression reflected anaemia development and iron deficiency, erythropoietin administration and inflammation, and we suppose that it could therefore serve as a useful marker of these clinical situations common in cancer patients and play a role in the pathogenesis of cancer-associated anaemia.
Evaluación de las propiedades psicométricas de las escalas de satisfacción con la vida, experiencia positiva y negativa, y prosperidad en población mexicana
Authors: Granillo Velasco Ana Daniela , Zepeda Goncen Georgina Daniela , Sánchez Aragón Rozzana
Published: September 2024

El bienestar subjetivo, que implica la autoevaluación de la experiencia de un conjunto de condiciones de la vida de una persona respecto a su funcionamiento óptimo, es un concepto multidimensional al cual se le han atribuido tres componentes —cognitivo-evaluativo, afectivo o hedónico, y eudaimónico—, y que se relaciona con variables como la salud, pues su presencia permite reducir tasas de mortalidad y conductas de riesgo. Para evaluar este concepto se han desarrollado diversas medidas, entre las que sobresalen la Escala de satisfacción con la vida (SWLS), la Escala de experiencias positivas y negativas (SPANE) y la Escala de prosperidad; no obstante, el análisis de sus propiedades psicométricas se ha centrado en resultados con estudiantes y fuera de México, por lo que en la presente investigación se tuvo como objetivos evaluar las propiedades psicométricas de estas tres escalas en población de la Ciudad de México, y determinar su grado de asociación con la variable salud como evidencia de validez. Se contó con la participación de 388 adultos con edades entre los 18 y los 62 años; y los resultados mostraron índices de confiabilidad (alfa de Cronbach) entre .84 y .89 en las tres escalas, así como un adecuado ajuste de los modelos (CMIN/DF < 3; GFI y CFI cercanos a 1; y RMSEA < .05), adecuada invarianza de medición, y que existen índices de correlación significativos (< .05) entre el bienestar subjetivo y la salud.
US-individualized infusion therapy in geriatric patients after emergency abdominal surgery: effect on the development of acute kidney injury
Authors: Momot N. V. , Tumanska N. V. , Vorotyntsev S. I.
Published: September 2024

In most elderly patients, prescribing the necessary volume of infusion therapy for the prevention of prerenal acute kidney injury (AKI) requires individualization. It is considered that ultrasound examination of the inferior vena cava (IVC) can be an effective additional method of assessing volemia in this category of patients.
The aim is to determine the effectiveness of infusion therapy based on ultrasound of the inferior vena cava for the prevention of AKI in geriatric patients after urgent abdominal surgery.
Materials and methods. A prospective single-center study included 50 patients (74.5 (68.0; 81.0) y. o.), divided into 2 groups: group A (n = 25, infusion therapy based on ultrasound of the IVC); group B (n = 25, infusion therapy based on changes in hemodynamic parameters and diuresis). The diameter of the IVC was determined using ultrasonography (ultrasound probe CN-6, SIEMENS, Acuson Antares), hemodynamic parameters were assessed using esCOO technology (Vismo PVM-2701K monitor, Nihon Kohden, Japan). The KDIGO classification was used to determine the presence and stage of AKI. Statistical analysis was performed using the program Statistica for Windows 13 (StatSoft Inc., No. JPZ804I382130ARCN10-J).
Results. The daily volume of infusion therapy in group A was 150 ml more than in group B (p = 0.049). Group A patients had 1.2 times higher CI (p = 0.016), by 6 mm Hg higher MAP (p = 0.012), 1.3 times greater SV (p < 0.001) than patients in group B. Also, they required 2 times less use of vasopressors (p = 0.026) and 2.8 times less use of diuretics (p = 0.008). Correlation between SV, CI, MAP and IVC diameter was weak but significant (r = 0.35, r = 0.25, r = 0.29, respectively, p ˂ 0.05). The incidence and severity of AKI did not differ between the study groups. In group A, the intensive care unit stay was 42 (35; 102) hours versus 80 (48; 176) hours in group B (p = 0.028) and survival rate was 88 % versus 40 %, respectively (p = 0.004).
Conclusions. Infusion therapy based on ultrasound of the inferior vena cava may be effective in geriatric patients after urgent abdominal surgery in the intensive care unit. The assessment of volemia based on the determination of the maximum diameter of the IVC is a good additional criterion for the individualization of the volume of postoperative infusion therapy aimed directly at the optimization of systemic hemodynamics and indirectly at the prevention of AKI.
Student views on how role-playing in a virtual hospital is distinctively relevant to medical education
Authors: Loke Swee-Kin , Blyth Phil , Swan Judith
Published: September 2024

Virtual worlds have the potential to enact the experiential learning of professional practices in simulated environments. The Otago Virtual Hospital (OVH) is one such virtual world where medical students role-playing as junior doctors make diagnoses and manage realistic clinical cases. To integrate the use of virtual worlds into existing curriculum, their distinctive relevance needs to be determined. A case study was conducted to find out how role-playing in the OVH is distinctively relevant to medical education. Following a trial involving 11 medical students completing the same scenario, three areas of relevance were identified: ?making the call?; self- organisation; and ?going through the whole process?. These areas can provide guidance to educators and staff developers who plan to recommend and sustain the use of virtual worlds in fields such as medical, legal, and management education.
Teaching Aboriginal Culture Online
Authors: Kutay Cat , Riley Lynette , Howard-Wagner Deirdre , Mooney Janet
Published: September 2024

This paper is an account of a research project being undertaken for an Australian Learning and Teaching Council grant to develop Indigenous On-Line Cultural Teaching & Sharing. The project is built on an existing face-to-face interactive presentation based on the theme of Australian Aboriginal Kinship systems, which has been designed for teaching university and school students and their teachers and describes the process used to develop web services that aim to provide more interactive and exploratory learning environments. We are collecting knowledge of the Aboriginal culture in relation to a theme and presenting this in a teaching framework that can be continually updated with community stories. We are consulting with Aboriginal and non-Aboriginal students and community members who attended interactive presentations to gather ideas for transferring the model to online format and presenting it with stories relevant to the specific professional areas of our students, such as sociology, law, education and social work. We present here the teaching framework developed in this project for Aboriginal cultural teaching online.
"Wherever, whenever" learning in Medicine
Authors: Koulias Marianna , Leahy Gregory , Scott Karen M. , Phelps Megan , Campbell Dianne
Published: September 2024

The increased availability of smartphones with Internet capabilities has led many educators to consider their potential for delivering mobile learning materials to students. In 2009 and 2010 three case-based scenarios were developed for mobile devices by staff at the University of Sydney and The Children's Hospital at Westmead. A trial of the pilot scenario was held with fourteen medical students in late 2009. The students were positive and made recommendations for improving the case scenarios. Their suggested changes were incorporated into phase two scenarios in 2010. Throughout 2011 evaluations were conducted with a total of 171 students and quantitative analysis of the data was performed. Results indicated that whilst students liked the mobile cases, they did not utilise them as mobile resources as anticipated. Some differences were also revealed between the digital immigrants' and digital natives' interactions with the case scenarios, as well as some variations between male and female students.
Designing evaluation and research into educational initiatives
Authors: Kelder Jo-Anne , Sondermeyer Juliet , Phillips Rob , Rothwell Anne
Published: September 2024

We describe the planning for evaluation research using a curriculum initiative project as a case study. The project was to design a generic Global Perspectives (GP) learning program to embed in first year units of study offered by the Faculty of Health Science. The pilot phase of the GP program delivery was used to explore and define an educational evaluation research (EER) plan that addresses, 1) the GP program design; 2) its implementation and ongoing refinement and, 3) the management of the project. The GP program is presented from an e-learning design perspective and its EER plan is based on the design framework in (Phillips, McNaught et al. 2012). The paper provides a high level view of the EER plan for the GP program over each stage of the design life cycle and for the evaluation of project management. The paper discusses the rationale for an EER plan, the book as a guide for research and practice in evaluating e-learning and the relationship of the GP program to learning, teaching and leading for the future.
Unsupervised Online Constructed-Response Tests
Authors: Johnson Genevieve , Davies Sharon
Published: September 2024

This paper reports a case study in which the Blackboard essay test tool was used to evaluate e- student learning. To promote student learning as well as maintain the integrity of test results, constructed-response items were randomly selected from a large pool of study questions and the time available to complete the tests was limited. The e-lecturer maintained a reflective journal and the e-students were invited, via email, to provide feedback on their perception of the value of the testing approach used in their e-class. Overall, students evaluated the use of the online tests positively, although issues of technology difficulties presented challenges for some students. The e-lecturer was particularly positive about the benefits of such as approach to online assessment citing ease of test management including student test submission, provision of feedback and grading. Unsupervised online constructed-response tests have the potential to enhance student learning while providing valid test scores.
Can Digital Natives Level-Up in a Gamified Curriculum?
Authors: De Byl Penny
Published: September 2024

The compulsion to include games and game related mechanism in education is great among educators who want to engage and motivate today?s students and the latest buzzword in this domain is gamification. However, without a thorough understanding of what a gamified curriculum looks like, how it can best be applied and why it might engross students, it cannot be effectively applied. This research examined a gamified course curriculum structure and evaluated its use in two university level subjects. The objective was to gauge student enjoyment and engagement with a heavily gamified curriculum and to understand the aspects that make the practice useful in education. Exploratory factor analysis of the dataset revealed the possibility of a six dimensional model of curriculum gamification worthy of future study.
Heutagogy and mobile social media
Authors: Cochrane Thomas , Antonczak Laurent , Gordon Averill , Sissons Helen , Withell Andrew
Published: September 2024

O'Reilly coined the term Web 2.0 seven years ago (O'Reilly, 2005), yet in the past seven years we have seen limited evidence of wide-spread impact of Web 2.0 on traditional higher education pedagogy. Seven years on, the social media landscape has changed and today?s school-leaving students are entering higher education within an increasingly post Web 2.0 society that is predominantly characterised by engagement with mobile social media. We argue that there is a need for higher education to engage with new pedagogies that are appropriate for an emerging post Web 2.0 society. We present a sustainable framework for preparing lecturers to engage with the challenge of post Web 2.0 pedagogies by experiencing the potential of mobile social media within authentic communities of practice.
Do Open Educational Resources represent additional challenges or advantages to the current climate of change in the Australian higher education sector?
Authors: Bossu Carina , Brown Mark , Bull David
Published: September 2024

This paper briefly reports on a number of Open Educational Resources (OER) initiatives in Australia, including some government programs and funding, then explores several of the challenges and advantages of adopting OER at institutional and individual (educators and learners) levels. This paper also discusses some of the preliminary findings of a centrally funded research project that investigates the state of play of OER in Australia. This project surveyed the higher education sector and interviewed key stakeholders. According to participants, the use of OER has the potential to lead to new pedagogical practices, can improve the quality of educational learning materials, and promote social inclusion across the Australian higher educational sector. However, there are still challenges to be overcome such as current academic culture, lack of awareness and issues related to finding quality materials. The above could represent additional challenges to the current climate of change faced by the higher educational sector in Australia.
ANU Campus Quest
Authors: Tutty Jodi , Leslie-McCarthy Sage
Published: September 2024

This paper outlines a new mobile application designed to assist student transition at the Australian National University (ANU). It briefly outlines the importance of addressing student transition in the current higher education climate, and explains why the ANU has decided to move into the mobile space in order to assist student transition to the geographical, social and institutional context of the university. The app is designed as an information-based scavenger hunt, informed by research into the social and learning utility of games. Students need to work in teams to devise strategies to approach the game, assisting them to make social connections, while the game itself takes students across campus to discover spaces and university cultures.
The design and development of a suite of online professional development resources for academic staff
Authors: Snell David , Terrell Jane
Published: September 2024

Professional development for teaching staff at Massey University has been comprehensively remodelled in order to foster teachers as “future makers”, exponents of models of teaching and learning that are suitable for effective 21st century knowledge creation and distribution. Given that the remodelling programme has strong support at significant levels of the university?s leadership, it has a high chance of succeeding in its aims. This paper traces the initial stages of one project in the programme: the production of a suite of online resources featuring successful academic staff discussing aspects of their teaching. Loosely modelled on other online teaching development videos, the videos in the suite were envisaged to provide staff new to teaching, and those wishing to improve their teaching practices, with a readily accessible, practical explanation of how some of Massey University?s leading practitioners operate. To help staff understanding at a deeper level, the suite included a series of brief information guides ("flyers") aimed at helping staff understand the theoretical terms underpinning the video discussions. This is an initial report on an on-going project.
Toward a framework for evaluating blended learning
Authors: Smythe Michael
Published: September 2024

Blended learning for some is the future of education itself (Brown & Diaz, 2010). However blended learning lacks a coherent body of research that unequivocally demonstrates learning benefits over traditional modes of instruction. Yet there is a growing volume of evidence to support the view that blended learning can result in improvements in student learning outcomes and enhance student satisfaction (Dziuban, Hartman, Cavanagh & Moskal, 2011; Garrison & Vaughan, 2008; Graham, 2006; Sharpe, Benfield, Roberts & Francis, 2006; Vaughan, 2007). The means to evaluate its effectiveness is frequently lacking since there are a relatively limited range of tools and methods that support staff in designing blended learning curricula. This paper describes one component of a possible framework for evaluating blended learning – the use of a course design rubric. A new rubric is outlined that attempts to represent a range of good practice in blended learning design derived from the literature and evidence-based research.
Early identification of students at risk of failing
Authors: Milne John , Jeffrey Lynn M. , Suddaby Gordon , Higgins Andrew
Published: September 2024

This paper outlines how teachers can use the learning management system (LMS) to identify at risk students in the first week of a course. Data is from nine second year campus based business courses that use a blend of face-to-face and online learning strategies. Students that used the LMS in the first week of the course were more likely to pass. For the rest of the course the pattern of usage is then largely similar for students who pass and those that do not pass. This paper identifies how a LMS can identify at risk students in the first week of the course and provides some strategies to motivate these students.
Relevant, current and sustainable digital strategies to prepare future teachers to lead e-learning
Authors: Mackey Julie , Davis Niki , Dabner Nicki
Published: September 2024

This paper describes how one teacher education programme integrates multiple strategies to ensure graduating teachers are prepared to lead e-learning in New Zealand classrooms. Contrary to recent criticism, initial teacher education (ITE) provides strong leadership in the innovative use of e-learning and digital technologies, and emphasises the digital capabilities, knowledge and confidence students need to succeed in their teacher preparation and beyond. This paper reports on the coherent range of strategies employed by one university that model good practice in blended online learning including: a social networking strategy to develop core digital skills; peer mentoring; the use of e-portfolios and Web 2.0 tools; as well as the integration of advanced e- learning pedagogies for course work. Evidence from several projects supports the claim that initial teacher education is developing essential e-learning leadership for future teachers and providing valuable professional leadership to the wider education sector.
Leading by Example
Authors: Huber Elaine , An Scarlet
Published: September 2024

This paper outlines the design of a study to investigate how a collection of example units was used as part of a wider training and support strategy during the transition between learning management systems. Example units can be thought of as a type of learning object or template from which innovative uses of learning technologies can be shared and used for professional development purposes in the design of online teaching spaces. Using a Developmental Evaluation approach, questions were asked about the authenticity and reusability of the example units to enhance their design in the next round of iterative planning. This paper will be of interest to Educational Developers and Academic staff interested in course design with technologies as well as co-ordinators of professional development strategies.
“It gave me a much more personal connection”
Authors: Forbes Dianne , Khoo Elaine , Johnson Marcia
Published: September 2024

This paper reports on a qualitative case study of an online initial teacher education class in New Zealand, exploring the potential of student-generated podcasts as a form of interactive formative assessment. Findings from interviews with teaching staff indicate that podcasting was useful for supporting multimodal learning valuing student voice and reflections. Podcasting enhanced the affective and relational connections in the online class, and empowered students to develop technical skills and confidence relevant in their teaching careers. As such, this study positions educators as future makers and as leaders in a climate of change. We suggest implications for student-generated podcasts in similar contexts.
Using a blogging tool to assess online discussions
Authors: Du Xinni , Daly Chris
Published: September 2024

This paper presents a summary of an experimental assessment design in a fully online undergraduate course. It details a task design relating to assessing discussion forum contributions and how lessons learnt from the original design have impacted on the current course design. From a task that often resulted in 2500 posts across a semester – impossible to read and assess in a fair and equitable manner to the combined design offered today. The task is equitable and manageable with the aim of building students’ capability as active learners.
Moodle Workshop activities support peer review in Year 1 Science
Authors: Cox Julian M. , Posada John Paul , Waldron Russell
Published: September 2024

Compulsory Science Faculty (SCIF) courses in various programs of study serve to provide students with a sense of belonging within their own cohort and with their professional future, as well as developing a range of skills relevant to that future. These aims are supported through completion of assessment tasks, which in turn are supported through the use of the Moodle learning management system. Specifically, the Workshop tool facilitates the practice of peer review, one of the processes in the course not only relevant to professional practice in the sciences but supporting active learning among students through noticing aspects of a range of tasks in which they can improve. This paper describes the use of the Workshop tool in its original form as well as modifications developed at the University of New South Wales (UNSW) to support the use of peer review and assessment processes associated with a range of assessment tasks.
Embedding eportfolios in teacher education
Authors: Allan Christopher , Cleland Ben
Published: September 2024

ePortfolios are being used in teacher education across Australia as a technology and as a process. They allow pre -and in-service teachers to showcase teaching practice against teaching standards and reflect on their practice throughout and after study. The University of Tasmania is implementing an eportfolio as an integral part of its Master of Teaching and Bachelor of Education programs to help with this process. This paper uses document analysis to describe the support strategies used in the previous two years of implementation of eportfolios at the university and outlines future plans for progressive implementation (including plans to change eportfolio technology and support implications). Some of the strategies used to implement eportfolios include: the use of a community of practice, the use of templates and scaffolds, support from L&T and IT infrastructure, embedding assessments in units; and modelling/building exemplars of effective portfolio practice.
Review It
Authors: Springett Ralph , Kirk Murray
Published: September 2024

Review It is a learner-led course evaluation tool providing advice from students to students who are finalising paper/offering choices as they progress through their study. Review It encourages reflection of the student’s learning experience, and asks what advice that student would give other students. Survey results are moderated and made public online. By directing students to consider how they engaged with the learning material and delivery of an offering, Review It provides prospective students insightful advice from a student perspective. Students may also choose commend a lecturer or offering. The Review It question line also captures student perceptions of weekly workload, how close the offering matched their expectations, and whether there were unforeseen additional costs in study materials and resources. The benefits of the survey extend both to students and the institution; students have access to first-hand course testimonials, while the institution benefits from the first hand reports of students’ satisfaction or dissatisfaction with their courses.
Building an Institutional Reporting Framework for Consensus Moderation Practices
Authors: Shapland Nicola D. , Nulty Duncan D.
Published: September 2024

This poster presents the initial findings from a two year Griffith University research project. The project entitled “Developing consensus moderation practices to support comprehensive Quality Assurance of Assessment Standards” is funded through a strategic Griffith Grant for Learning and Teaching, with ethical approval granted under reference number GIH/08/11/HREC. The poster describes the development of, and reports on the initial results from, applying a five level model of consensus moderation to assessment. Each level in the model describes a key stage in the assessment process, and a range of consensus moderation practices that would support quality assurance of assessment at that level. The reporting framework is imbedded in the University’s online Course Profile system and requires academics to report on their consensus moderation activities. Initial results confirmed this to be a meaningful reporting framework to gather and evaluate consensus moderation activities in use throughout the University.
Development of a framework for evaluating the impact and sustainability of mobile learning initiatives in higher education
Authors: Murphy Angela , Farley Helen
Published: September 2024

The field of mobile learning is becoming more capable of supporting high quality learning experiences and students are increasingly demanding greater mobility and flexibility. As a result, Higher Education Institutions are increasingly considering the implementation of institutional m- learning strategies. We present the aims and approach of a three year project to be conducted by the Australian Digital Futures Institute to develop an m-learning evaluation framework (MLEF) that will aid the selection and justification of m-learning initiatives. The framework will be encapsulated in an easy to use online evaluation toolkit which will consist of: a standardised evaluation framework, resources and guidelines; an m-learning maturity model; a database of m- learning exemplars; and an interactive mobile user model. The project is a collaborative initiative between USQ, ANU and UniSA and is supported through the Australian Government's Collaborative Research Networks (CRN) program. Participatory monitoring and evaluation (PM&E) methods will be used to develop outputs and deliverables.
Evaluation of lecture captures in mathematics and statistics for internal, hybrid and distance modes
Authors: Kemp Michael , Cullis Kerrie , Nielsen Sharon , Wood Robert
Published: September 2024

For several mathematics and statistics subjects we included a variety of video-based resources including lecture captures. We surveyed students and found they appreciated and felt they learnt from the videos. Additionally, we recorded usage data and found a positive relationship between number of lecture captures downloaded and exam performance.
Die ökonomische Politik Deutschlands gegenüber dem polnischen Königreich im ersten Weltkrieg
Authors: Łuczak Czesław
Published: September 2024

Die vom Deutschen Reich in der Anfangsphase des I. Weltkrieges an der Ostfront errungenen militärischen Siege und die als ihr Resultat erfolgte Besatzung eines Teiles des Polnischen Königreiches trugen zur Entwicklung der bereits vorhandenen und Entstehung neuer Germanisierungspläne der an die östliche Staatsgrenze Deutschlands anrainenden Gebiete bei. In diesen Plänen wurde vor allem die Gründung eines von den Deutschen besiedelten Grenzgebietes im westlichen Teil des Polnischen Königreiches postuliert. Es sollte die Polen der preußischen Besatzungszone von ihren im Polnischen Königreich wohnhaften Landsleuten trennen. Der territoriale Raum jenes Gebietes wurde in einzelnen Plänen unterschiedlich bestimmt, meistens wurde jedoch die Anlehnung an die Warthe, Narew, Biebrza und den Memel vorgesehen .
The circumstances surrounding the currency stabilisation in Poland in the years 1918-1993
Authors: Kowal Stefan
Published: September 2024

The necessity for stabilisation of the Polish currency after the First World War arose a number of times. Particular reasons accounting for the development of situations leading to déstabilisation were different and manifold depending on their timing. In the inter-war period, the reasons and the results of the destabilisation of currency in Poland and in some other European countries were characterised by similar features. Satisfying the conditions to be fulfilled on the way to stabilisation lay within the sovereign decisions of the Polish state and, in the main, did not extend beyond the boundaries of the domestic economic policy of the country. Under those circumstances, it was possible that the introduction of necessary changes or the correction of the economic policy to attain or maintain the desired state of the currency brought results more easily. External factors, though significant, were not decisive.
Representations of the Holocaust in the Jewish Museum in Kaliningrad
Authors: Leiserowitz Ruth
Published: September 2024

In November 2018, the reconstructed synagogue was inaugurated in Kaliningrad (Russian Federation) on the site of the house of worship destroyed on the night of the pogrom of 1938, Kristallnacht. Since 2022, a small Jewish Museum has also opened in the active synagogue, the centerpiece of which is a thematically conceptualized permanent exhibition. In the following article, the initial situation, mission, and thematic expectations for the creation of the permanent exhibition are described. It was desired that it should have an identity-forming and identity-promoting effect on the Jews of the Kaliningrad congregation and the entire region. Furthermore, it should be educational and entertaining for the population and tourists of the area, but also represent a place of remembrance of the former Jewish life and the Holocaust for the Jewish visitors of the region. Subsequently, the chosen exhibition media are described, as well as the selection of narratives and their respective media implementation. The text also sheds light on the object from the perspective of Jewish cultural heritage: The Kaliningrad region is one of the Eastern European post-displacement areas in which German traces (including German-Jewish traces) are regarded as a dissonant heritage. The authorized heritage discourse does not accept the consequences of the Holocaust here and ignores the city’s Jewish heritage. How can Jewish cultural heritage be made visible under these conditions? How can the new museum contribute to a change?
The Derivation of the Categories of Quantity
Authors: Haeck Levi
Published: September 2024

In this paper, I propose to resolve the controversy over the derivation of the categories of quantity by spelling out three claims: (1) the three quantitative functions/forms of judgment (universal-particular-singular), qua synthetic categories of quantity (unity-plurality-totality), lawfully direct the determination of sensible manifolds as singular totalities, which (2) brings to light a specifically categorial type of judgmental activity, distinguishable from but presupposed by empirical judgments. This calls for (3) pairing the category of totality with the singular judgment and the category of unity with the universal judgment (‘Order B’), rather than pairing the singular judgment with unity and the universal judgment with totality (‘Order A’). At stake in this controversy is our understanding of the categories’ normativity, their scope, and the division of labor between intuitions and categories in individuating objects.
Crystal structure of 1,1′,1″-(nitrilotris(ethane-2,1-diyl))tris(3-(4-(((E)-pyridin-2-ylmethylene)amino)phenyl)urea), C45H47N13O4
Authors: Li Jie , Dong Yinghan , Qiu Mengying , Han Haiwei , Pei Xiaoyan
Published: September 2024

C45H47N13O4, triclinic, P1̄ (no. 2), a = 10.242(6) Å, b = 14.766(15) Å, c = 15.503(8) Å, α = 70.91(2)°, β = 88.052(16)°, γ = 74.13(3)°, V = 2127(3) Å3, Z = 2, R

gt
(F) = 0.0411, wR

ref
(F
2) = 0.1059, T = 120(2) K.
The crystal structure of N-benzylquinoline-2-carbothioamide, C17H14N2S
Authors: Zhu Xiaoming , Ou Jiaqi , Luo Na , Deng Yuxuan , Nie Yuming , Xiang Jiafeng , Fang Shixin
Published: September 2024

C17H14N2S, Orthorhombic, P212121 (no. 19), a = 5.9687(10) Å, b = 8.4626(14) Å, c = 28.786(5) Å, V = 1454.0(4) Å3, Z = 4, R
gt(F) = 0.0315, wR
ref(F
2) = 0.0824, T = 296(2) K.
Neurobiological mechanisms in the kynurenine pathway and major depressive disorder
Authors: Bertollo Amanda Gollo , Mingoti Maiqueli Eduarda Dama , Ignácio Zuleide Maria
Published: September 2024

Major depressive disorder (MDD) is a prevalent psychiatric disorder that has damage to people’s quality of life. Tryptophan is the precursor to serotonin, a critical neurotransmitter in mood modulation. In mammals, most free tryptophan is degraded by the kynurenine pathway (KP), resulting in a range of metabolites involved in inflammation, immune response, and neurotransmission. The imbalance between quinolinic acid (QA), a toxic metabolite, and kynurenic acid (KynA), a protective metabolite, is a relevant phenomenon involved in the pathophysiology of MDD. Proinflammatory cytokines increase the activity of the enzyme indoleamine 2,3-dioxygenase (IDO), leading to the degradation of tryptophan in the KP and an increase in the release of QA. IDO activates proinflammatory genes, potentiating neuroinflammation and deregulating other physiological mechanisms related to chronic stress and MDD. This review highlights the physiological mechanisms involved with stress and MDD, which are underlying an imbalance of the KP and discuss potential therapeutic targets.
The Potential of Deleterious rhizobacteria to Control Primary Weed Echinochloa sp. on Rice
Authors: Hoesain Mohammad , Masnilah Rachmi , Nurchayanti Suhartiningsih Dwi , Pradana Ankardiansyah Pandu , Alfarisy Fariz Kustiawan , Sari Dwi Tirta , Ramadhan Farchan Mushal Al , Rismayani  , Tarigan Sri Ita
Published: September 2024

Deleterious rhizobacteria (DRB) is one of the rhizobacteria that can be used as a bioherbicide and can stimulate plant growth. The objectives that can be obtained from this study are to determine the potential of DRB on the growth of weeds Echinochloa crusgalli and Echinochloa colona on rice. Variables observed in this study were identification of secondary metabolites, measurement of weed sprouts, percentage effectiveness of bacterial isolates against weed seeds, normal sprouts, abnormal sprouts, fresh seeds that did not grow and dead seeds. The aim of this study is to explore biological agents that can be used to control the main weeds of rice crops. This candidate could be a recommendation for environmentally friendly controls. Exploration of the DRB group was obtained by collecting soil samples around the roots of rice crops. Then isolate it, identify as morphologically and physiologically, and test it in vitro studies. The results showed that DRB had the potential to control weed growth and could stimulate the growth of rice. The application of PFA and PFB isolates had a significant effect on inhibiting the length of weed roots and buds, the average percentage of control effectiveness > 80-90%. Novelty in this study could be found as candidate groups of DRB bacteria with specific locations to control the weed Echinochloa sp. on rice crops. For society, this research could be an alternative to reduce dependence on synthetic herbicides . DRB has the potential to be formulated into a bioherbicide  to control weeds.
Efecto de las emociones sobre la empatía en adolescentes vulnerables
Authors: Narváez Marín Mariela , Gómez Tabares Anyerson Stiths , Correa Duque María Cristina
Published: September 2024

Este estudio analiza el efecto de la autoeficacia emocional, la irritabilidad y la agresividad sobre la empatía en adolescentes vulnerables. Estudio cuantitativo, no experimental- transversal y alcance correlacional. Participaron 69 adolescentes, a quienes se les aplicó el Índice de Reactividad Interpersonal y las Escalas de Autoeficacia para la Regulación Emocional, Irritabilidad y Agresividad Física y Verbal. La empatía correlacionó directamente con la autoeficacia emocional e inversamente con irritabilidad y agresividad física y verbal. El análisis de rutas mostró que la autoeficacia emocional, irritabilidad, agresividad física y verbal aportaron un efecto predictor sobre la toma de perspectiva, preocupación empatía y malestar emocional.