bluuebunny/crossref_metadata_2025 huggingface dataset:
Kronik spontan ürtikerde omalizumab tedavisinin etkinliği: Retrospektif bir çalışma
Authors: YILDIRIM Fatmaelif
Published: December 2020

Amaç: Bu çalışmada tedaviye dirençli kronik spontan ürtiker (KSÜ) nedeni ile omalizumab tedavisi kullanan hastaların klinik ve demografik özelliklerinin yanısıra omalizumab etkinliği ile yan etkilerinin geriye dönük olarak değerlendirilmesi amaçlanmıştır.

Gereç ve Yöntemler: Kliniğimizde 2014-2017 yılları arasında H1-antihistaminiklere direnç nedeni ile 300 mg/ay subkutan omalizumab başlanan KSÜ hastalarının kayıtlı bilgisayar verileri taranarak retrospektif olarak incelendi. Hiç ürtikeryal plağı ve kaşıntısı olmayanlar tam yanıtlı, tedavi başlangıcına göre hayat kalitesi artan ve semptomlarında belirgin iyileşme olanlar kısmi yanıtlı, semptomlarında hiç iyileşme olmayanlar yanıtsız olarak kabul edildi.

Bulgular: Tedaviye dirençli KSÜ nedeniyle omalizumab verilen 71 (41 K, 30 E) hasta çalışmaya dahil edildi. Bu hastaların ortalama hastalık süresi 54.6±52.9 (min-maks:8-360) ay olup, yaş ortalaması 43.6±16.4 (min-maks: 14-83) yıl idi. Omalizumab tedavisi 3. ayı sonunda hastaların yapılan değerlendirilmesinde, 14 (19.7%) hastada tam yanıt, 36 (50.7%) hastada kısmı yanıt görülürken, 21 (%29,6) hastada yanıt alınamadı. Başlangıç total IgE ve CRP düzeyleri, hastalık süresi, hasta yaşı, cinsiyeti, astım öyküsü ve immünsupresif kullanım öyküsü açısından 3. ay sonu omalizumab tedavisi yanıt grupları arasında herhangi bir istatistiksel farklılık tespit edilmedi (p>0.05). Hastalarda ciddi bir yan etki saptanmadı.

Sonuç: Bu çalışmada, KSÜ nedeniyle takip edilip omalizumab kullanılan hastalarda, omalizumab tedavisinin etkin ve güvenilir olduğunu tespit ettik.
Prisoner-of-war stories in the movies (the case of Andrzej Munk’s Eroica)
Authors: Matuchniak-Mystkowska Anna
Published: December 2020

This paper analyses Polish feature films which deal with the subject of POW camps during World War II, especially the so-called oflags (German: Offizierslager), i.e. Wehrmacht camps for officers. In Poland, nearly 200 feature films about World War II and the Nazi occupation were made in 1945–1999, with only eight raising the topic of POW camps. Eroica directed by Andrzej Munk is one of the first examples, and the best-known one. It depicts the social world of the oflags in a grotesque and ironic light, which was acclaimed by film experts but criticised by historians. The theoretical and methodological approach used in the sociology of art and in historical sociology can be invoked to analyse all the elements of the communication system: the creator, the work, and the audience in their social and historical context. The sociological analysis presented here only concerns the content of the film (the juxtaposition of “the truth of time” and “the truth of the screen”) and its social reception among different categories of viewers, each with their specific competences. The theoretical concepts developed by S. Ossowski, A. Kłoskowska, P. Francastel, E. Panofsky and P. Bourdieu are used here, alongside historical and sociological analyses of POW camps (D. Kisielewicz, A. Matuchniak-Mystkowska). The paper presents a certain research idea and describes methods that can be used to pursue it.
CHAMADA PÚBLICA nº. 02/2017 - O Império e as Prová­ncias: configurações do estado nacional brasileiro no século XIX
Authors: Cavalcante Anissa Ayala
Published: December 2020

A Revista Outros Tempos, do Curso de História da Universidade Estadual do Maranhão (UEMA), torna pública a chamada de  nº 02/2017, para seleção de Artigos, Resenhas e Estudo de Caso, que comporão o volume 15 número 26,  do mês de  julho/dezembro de 2018, para o dossiê temático ”O Império e as Prová­ncias: configurações do estado nacional brasileiro no século XIX”, sob organização de  Wilma Peres Costa, professora da Universidade Federal de São Paulo (UNIFESP/Brasil) e  Marcelo Cheche Galves, professor da Universidade Estadual do Maranhão (UEMA/Brasil).
CHAMADA PÚBLICA n. 04/2019 - Dossiê: ”História Antiga pra quê?” Questões antigas para problemas contemporá¢neos”
Authors: Cavalcante Anissa Ayala
Published: December 2020

A Revista Outros Tempos, do Curso de História da Universidade Estadual do Maranhão (UEMA), torna pública a chamada de nº 04, para seleção de Artigos, Resenhas e Estudo de Caso, que irão compor o volume 16, número 28, jul./dez., 2019, para o dossiê temático: ”História Antiga pra quê?” Questões antigas para problemas contemporá¢neos”, sob organização de:  Ana Livia Bomfim Vieira, professora da Universidade Estadual do Maranhão (UEMA/Brasil)
CHAMADA PÚBLICA 06/2019 - Submissão de propostas de Dossiês: edições 2020.2 e 2021.1
Authors: Cavalcante Anissa Ayala
Published: December 2020

A Revista Outros Tempos, do Curso de História da Universidade Estadual do Maranhão (UEMA), torna pública a chamada nº 06/2019, com o objetivo de selecionar propostas de dossiês temáticos na área de História para publicação no volume 17, número 30 (2020.2) e volume 18, número 31 (2021.1).
[ARTIGO TRADUZIDO] IDEOLOGY AND TRADITION OF DRUG USERS IN THE COLONIAL AMAZONIA
Authors: AVELAR LUCAS ENDRIGO BRUNOZI
Published: December 2020

Abstract: In this text, we seek to indicate how the bearers of a religious ideology of medieval origin described the drunkenness of the indigenous peoples in the 18th century Amazon. We privileged the analysis of the accounts of the work ”Tesouro Descoberto no Máximo Rio Amazonas” by the Portuguese Jesuit, João Daniel. Highlighting the contradictions and approximations established between, on the one hand, a colonization based on the production and commerce of drugs and Catholic food tradition based on wine and bread, and on the other hand, an ideology of abuse elaborated to account for the indigenous tradition of drinks ingestion and substances extracted from the forest.  Keywords: Colonial Amazon. Drunkenness. Drugs. Missionaries.
Genetic diversity of enteroaggregative Escherichia coli
Authors: Makarova M. A. , Kaftyreva L. A.
Published: December 2020

Studied 74 E. coli strains isolated from stool samples (60) and urine samples (14) of patients examined for clinical indications. Molecular methods included: PCR with electrophoretic detection of genes associated with diarrheal E. coli pathogroup EAgEC (aggR, aaf, aap, aatA, pet, ast, aai) and ExPEC pathogroup UPEC (pap, sfa, afa, kpsMT II, iutA, hlyA, cnf), MLST typing, whole genome sequencing. Strains isolated from stool samples were significantly more likely (88.3%, p > 0.05) to be typical EAgECaggR+ compared to atypical EAgECaggR-. Strains isolated from urine samples, significant differences between typical and atypical EAgEC were not detected (p > 0.05). Genes associated with ExPEC were present in all strains isolated from urine samples and in 45 strains (75%) isolated from stool samples. Coproisolates belonged to 10 serogroups and 13 serovars: O3:H2, O11:H10, O16:H48, O51:H30, O55:H21, O73:H18, O73:H33, O86:H2, O86:H10, O92:H33, O140:H2, O159:H10. Two strains had unique nucleotide sequences of genes encoding O-antigens that were missing from the SerotypeFinder database. 80% of EAgEC isolated from feces and urine was characterized by an enteroaggregative/uropathogenic genotype (EAgEC/UPEC). Most of the strains isolated from urine belonged to the virulent clone of high-risk epidemic spread ST 38 associated with hybrid strains of UPEC / EAgEC.
Apport Des NÃ©gro-Africains Au DÃ©veloppement De La GÃ©omancie Et De La MathÃ©matique
Authors: Mayer Raoul Ã‰tonguÃ©
Published: December 2020

Les impressions et les interprÃ©tations d'artefacts archÃ©ologiques dÃ©pendent en grande partie de l'expÃ©rience personnelle. Elles ne font appel Ã  aucune autoritÃ© dogmatique, car elles adhÃ¨rent Ã©troitement Ã  la vÃ©ritÃ© recherchÃ©e par les scientifiques qui veulent expliquer les palÃ©o environnements en fonction de lâ€™expÃ©rience des donnÃ©es recueillies. Dans le cas prÃ©sent, l'analyse des donnÃ©es et les conclusions ont permis de confectionner ce que l'on pourrait, par exemple, appeler le discours des os d'Ishango. L'objectif de ce travail est d'amÃ©liorer la comprÃ©hension du petit os d'Ishango en confrontant le dÃ©chiffrement de ses caractÃ©ristiques et une feuille de ponctuation d'un thÃ¨me gÃ©omantique. La mÃ©thode gÃ©omantique qui consiste Ã  faire une sÃ©rie de petites lignes verticales a alors Ã©tÃ© appliquÃ©e Ã  la lecture et Ã  l'analyse du symbolisme du petit os dâ€™Ishango. La lecture visuelle de la morphologie structurale du petit os d'Ishango a Ã©tÃ© rÃ©alisÃ©e en utilisant le corpus Ã©sotÃ©rique des connaissances de la religion universelle transmises dans le secret initiatique depuis la nuit des temps. Les analogies confirment un lien fort entre les connaissances occultes, la gÃ©omancie et les mathÃ©matiques dans la conception des os d'Ishango qui a eu lieu aux confins des Grands lacs africains il y a au moins 25 ka.
Impressions and interpretations of archeological artefacts are drawn largely from peopleâ€™s personal experience not appealing to any dogmatic authority, but because they closely adhere to the truth, adamantly hunted by scientists who want to explain paleo environments based on gathered evidence. Analysis of evidence, and findings worked out a set of assumptions what might for instance, be called the discourse of the Ishango bones. The objective of this paper is to improve the understanding of smaller Ishango bone by confronting the deciphering of its strokes and a punctuation sheet of a geomantic theme. Geomantic method of making a series of strokes is applied to the analysis of the symbolism of smaller Ishango bone. Consequently, a visual reading of the structural morphology of smaller Ishango bone was used based on esoteric corpus of knowledge related to the universal religion of the ancient and prehistoric world. Analogies confirm a strong tie between occult knowledge, geomancy and mathematics in the designing of the Ishango bones that took place on the edge of African Great Lakes at least 25 ka ago.
¿Qué sucederá con la internacionalización de la educación superior y la movilidad estudiantil después del COVID-19?
Authors: Gómez López Pamela
Published: December 2020

La internacionalización es un proceso que se lleva a cabo en las instituciones de educación superior con diferentes objetivos, y con su implementación se busca integrar una mirada internacional e intercultural en las funciones de las universidades. Este proceso se compone de diversas estrategias, y, entre las más conocidas, se encuentra la movilidad estudiantil. En las últimas décadas la internacionalización ha cobrado más relevancia, sin embargo, es un proceso que aún carece de un entendimiento integral y se realiza de acuerdo con las intenciones y recursos de las instituciones. Con la llegada de la enfermedad COVID-19, la internacionalización y la movilidad estudiantil se encuentran ante un futuro incierto, ante la urgencia de resolver otras necesidades en las instituciones, por lo que se comienzan a explorar otras formas de implementarla.
Optimización del avance lineal en las labores de exploración y desarrollo de la Unidad Minera Santa María - Compañía Minera Poderosa S.A. con la aplicación de los criterios fundamentales de la ingeniería de la voladura
Authors:   ,   Universidad Peruana de Ciencias Aplicadas (UPC), Diaz Bustamante Gianlucas Wanderley , Sotelo Molero Cesar David
Published: December 2020

En la presente tesis se estudia la aplicación de los principios matemáticos de Holmberg y sus colaboradores. Dichos principios se encuentran descritos en el libro Rock blasting and explosives engineering que tiene como finalidad demostrar de manera práctica la importancia de realizar un adecuado diseño de la malla de perforación y voladura. Esto se llevó acabo, en primer lugar, con el mapeo geomecánico (RMR), el análisis del arranque a utilizar, así como la longitud de barrenos y el explosivo óptimo para el cebo y la columna de carga. Esta investigación se realizó en la Unidad Minera Santa María de Compañía Minera Poderosa S.A., donde se demostró que el cambio de diámetro en los taladros de alivio del arranque de 38 mm a 64 mm y el uso adicional de barrenos de 8 pies para la sección de 2.5 m x 2.7 m, contribuye a ser eficientes en cada disparo. En esta misma instancia, se demostró que, aplicando de manera óptima los principios matemáticos utilizados se puede reducir notablemente la cantidad del uso de explosivos, viéndose reflejado en un ahorro económico por disparo. Los resultados obtenidos con el nuevo diseño son: el factor de potencia pasó de 1.23 a 1.15 kg/t reduciendo un 6.8 %, el avance por disparo de 1.51 a 2.10 m aumentando un 39.2 % y el factor de carga lineal de 23.24 a 21.02 kg/m reduciendo un 9.6 %; lo cual se traduce en un ahorro mensual por frente de trabajo de S/. 21,421.12.
Modelo Tecnológico de Reconocimiento Facial para la Identificación de Pacientes en el Sector Salud
Authors:   ,   Universidad Peruana de Ciencias Aplicadas (UPC), La Madrid Arroyo Diego Alonso , Barriga Rivera Martín Humberto
Published: December 2020

El fraude médico y los ciberataques en el sector sanitario son fenómenos en aumento. La suplantación de identidad es una modalidad de fraude que tiene como propósito asumir la identidad de otra persona en una institución médica para obtener bienes y servicios médicos a las aseguradoras presentando reclamaciones falsas obteniendo un beneficio económico. Por lo tanto, afecta a la población asegurada ya que involucra un monto invertido, tiempo y servicio brindado. Sólo es necesario presentar documentos de identidad para ser atendido, la cual puede ser una medida de verificación y validación de alto riesgo para el paciente si se trata de algún fraude, debido a que cuando una persona usa la identidad médica de la víctima para obtener servicios médicos o medicamentos con receta, esa información se incorpora a la historia clínica electrónica de la víctima y puede complicar su atención médica en el futuro. Identificar al paciente de forma segura e inequívoca es de vital importancia para el paciente, impidiendo que nadie pueda suplantar su identidad. El presente proyecto detalla el desarrollo de un modelo tecnológico que tiene como objetivo la identificación de pacientes mediante un servicio cognitivo de reconocimiento facial en Cloud computing para cubrir la necesidad que tienen los sectores de salud de prevenir la suplantación de identidad. Además, en caso de emergencias, se alerta a los parientes del paciente identificado el estado de salud en el que se encuentra mediante un mensaje de texto. Se espera que el modelo les permita a los pacientes ser atendidos sin la necesidad de contar con un documento de identidad en caso se encuentren en estado de emergencia y prevenir fraudes como las suplantaciones de identidad. Finalmente, se definirá un plan de continuidad que contenga mecanismos de respaldo en tiempo real para la disponibilidad y confiabilidad. Asimismo, se contará con recursos a nivel de software, los cuales serán detallados en base a características, especificaciones y uso.
Modelo para la evaluación del riesgo crediticio para los clientes de las microfinancieras del Perú
Authors:   ,   Universidad Peruana de Ciencias Aplicadas (UPC), Alarcón Morales Eduardo Manuel , Mora Ramos Brian Javier
Published: December 2020

El riesgo crediticio es un problema que viene afectando a las microfinancieras desde su nacimiento debido a que existe una probabilidad de que el cliente no termine de pagar el préstamo llegando inclusive al cierre de alguna de estas instituciones. En el Perú, la totalidad de empresas financieras utilizan el índice de morosidad como un indicador para medir el porcentaje de créditos no pagados con respecto a la totalidad de colocaciones, siendo en las microfinancieras el doble de la banca regular. Por este motivo, en la presente investigación se diseña un modelo de predicción que permite una mejor toma de decisiones al momento de evaluar al prestatario, utilizando variables estándares y comunes, herramientas y algoritmos modernos que permitan una mejor evaluación de las variables con respecto a la información brindada. El resultado de la investigación muestra las variables y los porcentajes de predicción de pago con la información brindada por una microfinanciera aplicando el algoritmo de redes bayesianas. Para esto, este proyecto demostró la eficacia del modelo planteado como un medio para obtener una fuente fidedigna con respecto a la evaluación de los créditos de consumo de manera objetiva. El modelo cuenta con 5 etapas: 1. Los elementos de entrada; 2. El proceso de evaluación y el análisis; 3. Las regulaciones estandarizadas; 4. La arquitectura tecnológica; 5. Los elementos de salida. Como resultados se obtuve una predicción promedio de las prestatarios de un 63%; así mismo, se evaluaron otros factores del modelo como la sensibilidad y la especificidad que ayudaron a la construcción del mismo.
AfCTA and the Trajectory of Industrialisation and Development Sustainability in Africa
Authors: Sibanda Omphemetse S.
Published: December 2020

In 2018 the African Union Commission launched the first Africa Industrialisation Week to promote regional value chains development in Africa, to provide A Pathway for Accelerating Africa’s Structural Transformation, Industrialisation and Pharmaceutical Production. This paper will investigate the trajectory and key elements of Africa’s industrialisation. In particular, the paper will look into how the industrialisation will promote and enhance its sustainable development. Considered also will be harmonisation and regional integration; economic strategies beneficial for African countries; appropriate regulatory and policy regime; and issues structural transformation including reallocation of economic activities from less productive to more productive industrial sectors.
Apitherapy and Health
Authors: ÖZDEMİR Gökçe , ERSÖZ Elmas , DİLEK Nazik
Published: December 2020

Apitherapy is a word derived from the Latin word apis, meaning bee. Apitherapy application dates back hundreds of years. There are documents showing that physicians in Ancient Egypt and China used some bee products 4 thousand years ago. Apitherapy is used as an effective method for maintaining health and treating diseases. The main products used in this method are honey, apilarnil, propolis, royal jelly and perga. These products used in apitherapy are generally known to have very important effects such as antibacterial, antioxidant, anti-inflammatory, vasodilating and antitumor effects. In addition to its positive effects, studies have shown that the use of some apitherapy products may cause an allergic reaction. As a result, the use of these nutrients obtained from reliable sources has beneficial effects on health.
Przestępstwo przyjęcia zlecenia zabójstwa (art. 148a § 1 k.k.) w ujęciu nowelizacji kodeksu karnego z 13 czerwca 2019 roku
Authors: Kokot Rajnhardt
Published: December 2020

Opracowanie podejmuje problematykę nowego, wprowadzonego mocą nowelizacji kodek-su karnego z 13 czerwca 2019 roku, przestępstwa odpłatnego przyjęcia zlecenia zabójstwa (art. 148a § 1 k.k.). Nie ulega wątpliwości, że jest to rozwiązanie bezprecedensowe, nadające zasadzie ochrony życia i jej zakresowi zupełnie nowego znaczenia. Wyprowadza ono ochronę życia z dotychczaso-wych ram zachowań zabronionych chroniących to dobro, przesuwając ją na płaszczyznę zachowań, które nigdy dotąd nie były karalne, bardzo oddalonych od wystąpienia zamierzonego przez sprawcę skutku. Przestępstwo to, na co zwrócono uwagę już w toku prac nad nowelizacją ustawy karnej w licznych opiniach formułowanych przez przedstawicieli środowiska karnistycznego, budzi wiele wątpliwości, w tym takie, które wiążą się z poszanowaniem przez tę ustawową konstrukcji funda-mentalnych zasad prawa karnego. Kryminalizacja zachowań na tak odległym przedpolu naruszenia dobra prawnego może być w szczególności źródłem kontrowersji w kontekście gwarancyjnej funkcji prawa karnego. Przeprowadzona analiza ma na celu zwrócenie uwagi na kilka najistotniejszych kwestii dotyczących tego przestępstwa, między innymi jego charakteru prawnego, uzasadnienia jego typizacji, konstrukcji jego ustawowych znamion, możliwych przypadków zbiegu przepisów czy przestępstw, w których może pozostawać, trudności, jakie nowa konstrukcja może nieść dla praktyki wymiaru sprawiedliwości, a także samej potrzeby wprowadzenia omawianej „modyfikacji granic” prawnokarnej ochrony życia człowieka.
Wpływ działalności uchwałodawczej NSA na wykładnię i stosowanie prawa
Authors: Kozicka Beata
Published: December 2020

W pracy przedstawiono zagadnienie charakteru i roli uchwał Naczelnego Sądu Admini-stracyjnego, zwłaszcza na etapie stosowania prawa. Zaprezentowano pozycję i uprawnienia NSA do podejmowania uchwał mających na celu wyjaśnienie przepisów prawnych, których stosowanie spowodowało rozbieżności w orzecznictwie sądów administracyjnych. Podjęto przy tym rozważania na temat ich prawotwórczej roli.
Ewolucja polityki etnicznej w Polsce w latach 1944–1989
Authors: Szczepański Andrzej
Published: December 2020

This article is devoted to the issue of politics of ethnicity in Poland in the period 1944–1989, which is a consequence of post-war changes in the ethnic structure of the country and its national homogenization. The attitude of state authority toward its non-Polish residents, on the one hand, enabled them to maintain their own limited identity, but on the other hand, meant that they were deliberately assimilated in order to integrate with the rest of society. In particular periods, these activities were conducted with different intensification levels and with different tools.
Partycypacja obywatelska na poziomie lokalnym — przykład miasta Opola
Authors: Daniel Katarzyna
Published: December 2020

The issue of citizen participation at the local level becomes important in the practice of Polish cities. However, it should be noted that the initiatives on participation in social consultations undertaken in this area are of an optional nature. The experiences of individual urban centres regarding the involvement of residents in this type of political participation are probably very diverse. The participation of the local community enables real recognition and taking into account the needs and expectations of the residents regarding shaping their immediate environment. Thus, it influences the improvement of the quality of life and the optimization of the urban offer. Bad experiences from participation may result in weakening the willingness to continue (both by local authorities and residents). To promote good practices, it is therefore necessary to systematize knowledge in the field of research in question. The aim of the article is at least partially to fill the gap in the presented research area, while the research perspective narrows down to the administrative borders of the city of Opole. Due to the diversity of participation categories referring to the term “civic participation”, it should be noted that the content of this article focuses only on two of them, namely the involvement of Opole’s residents in public consultations and the civic budget.
Szarmata sebészi trepanációk a Kárpát-medencében
Authors: BERECZKI Zsolt , MADÁCSY Tamara , KIRÁLY Kitti , SÓSKUTI Kornél , PAJA László
Published: December 2020

Despite the abundance of written resources and bioarcheological remains from the era, very few trephined skulls have been unearthed so far from the territory of the Roman Empire. In the territory of today Hungary, more than 130 surgically trephined skulls have come to light, with the earliest evidence deriving from the Neolithic period. However, the Hungarian literature does not mention any unequivocal Roman finds from the province of Pannonia (today Western Hungary). Earlier publications and osteological researches of the last fifteen years, however, have already yielded 6 possible cases of trepanation from Barbaricum, the Sarmatian territory partly enclosed by Roman provinces (today Eastern Hungary). The authors wish to re-examine these 6 cases, evaluate and justify their inclusion as Sarmatian trepanations, and put forward a possible explanation of the controversy between the written resources and the osteological evidence.
A nazomaláris szög és szimotikus húr alkalmazása metrikus alapú taxonómiai osztályozási feladatokban
Authors: SZENICZEY Tamás
Published: December 2020

Ancestry can be estimated in a probabilistic framework using facial morphological signatures of the different population histories. While the assessment of qualitative traits requires more experience, the measurement of the most distinctive quantitative characters usually demands anthropological tools seldom available. However, some of the facial measurements related to ancestry can be easily recorded with a caliper. The study aims to present the efficiency of simotic chord (SC) and nasomalar angle (M77) in ancestry estimation by applying supervised and unsupervised algorithms to classify skulls with European and Asian ancestry. Linear discriminant analysis and Gaussian Mixture models were applied to a subset of the Howells’ craniometric dataset comprised of individuals with European and Asian ancestry. Prediction of ancestry was carried out on a set of craniometric traits describing height, length and width parameters of the crania and then repeated on this set supplemented with M77 and SC measurements. An increased percentage of true positive prediction of ancestry was achieved by involving the M77 and SC measurements.
Bilinguism and other manifestations of the functioning of the Language System in light of Brain Plasticity
Authors: Alexandrova Nina Sh.
Published: December 2020

The work is devoted to the biological basis of bilingualism. The manifestations of the functioning of the language system — mastering the native language in a monolingual environment, natural bilingualism, artificial bilingualism, written speech and the functioning of the language system in pathology — are analyzed in the light of ideas about the plasticity of the brain, the differences in the processes of forgetting the language material are discussed. Issues of practical importance are discussed: who can be called bilingual and when a child can become bilingual. The concept of natural bilingualism as a biological adaptation, which occurs when it is necessary to understand two languages, is substantiated. This adaptation is impossible until the moment the child's understanding of the language is formed, i.e. bilingualism is impossible in infancy.
Adaptation of Personal Names: Transliteration, Transcription or Renomination?
Authors:   Peoples’ Friendship University of Russia, Krasina Elena A. , Aleksandrova Oksana I.
Published: December 2020

Lexical-and-semantic class of personal names is characterized with a number of specific properties and functions. Synchronically, without appealing to etymology, those individual (individualized) names fulfil a secondary nomination function due to their semiotic function, which makes it possible interpret personal names as symbolic cultural codes belonging to national linguistic worldviews. Still, in course of cross-cultural communication, linguistic contacts demand personal names be translated from one language to another one. The aim of the article is to demonstrate the possibility of adaptation of personal names conserving their own semiotic and national identity while being globally transposed both into various languages and linguistic worldviews, including the general global linguistic worldview. As is generally acknowledged, due to the intranslatability of personal names, though languages of the European area reveal some correlations, the principle method to adapt them in literary and mass-media texts as well as in course of colloquial communication is the transformation of their exterior sound-and-letter form, so the foreground is made by the norms and rules of transliteration on the basis of the so-called “ideal” Latin alphabet and “practical” transcription which are closely interconnected and fixed as standard ones in the documents of international associations, e.g., ISO, MFO, etc. However, the alphabets and pronouncing norms of national languages are realized controversially which inevitably leads to developing variations and the necessity to revise the established standards. The implicitly positive result of personal names adaptation is the unification of transliteration, considering that even for languages using the hieroglyphic or letter-syllabic writing systems, special alphabets are developed, e.g., pingyin for Chinese or hangul for Korean, which have to provide the conventional communication in the intersection of languages and culture.
Symbiosis of “national language models” in I. Babel’s “Konarmia” and methods of its analysis
Authors:   South Ural State Pedagogical University, Podobriy Anna V. , Lukinykh Natalya V. ,   Academic Lyceum No. 95, Chelyabinsk
Published: December 2020

Isaak Babel has always been a “mystery” for researchers. Russian Russian Russian literature and language, he created different images of national worlds: Russian, Polish, Cossack, Jewish. Moreover, these worlds did not exist separately from each other, they were included in the dialogue, thus embodying the “patchwork” of the world of a new social culture, built on the ruins of the Russian Empire. “Konarmiya” showed the possibilities of such a dialogue, and the huge selection of artistic means used to create it makes the author an object of special interest both from literary critics and linguists.
Ontological Prerequisites for the Study of Creolized Text’s Semantic Perception
Authors:   Russian Institute of Theatre Arts — GITIS, Kosenko Viktoria S. , Sinyachkin Vladimir P. ,   Peoples’ Friendship University of Russia
Published: December 2020

With this paper we try to comprehend the phenomenon of creolized text as a semiotic complex existing in the unity of verbal and non-verbal components. Creolized texts, combining the verbal part with visual fragments, make up most of the texts that function in the media and virtual data. Therefore, scientific information that reveals the influence of the verbal and non-verbal parts of a creolized text on its semantic perception has pragmatic value. The term “creolized text” is analyzed in our work from the point of view of its inclusion in the paradigm of semantically close definitions: “linguo-visual complex”, “polycode text”, “complex semiotic whole”. The main stages of the study of creolized text in world and Russian science are presented in a diachronic sequence. The basic parameters of perception of the creolized text are considered. The research is intended to acquaint the reader with the main milestones in the history of the study of this phenomenon and to provide its detailed terminological definition.
ARIA 2019: Um Percurso Assistencial Integrado para a Rinite Alérgica em Portugal
Authors: Fonseca João , Taveira-Gomes Tiago , Pereira Ana Margarida , Branco-Ferreira Manuel , Carreiro-Martins Pedro , Alves-Correia Magna , Correia de Sousa Jaime , Costa Elísio , Lourenço Olga , Morais-Almeida Mário , Morête Ana , Regateiro Frederico , Todo Bom Ana , Bachert Claus , Pfaar Oliver , Wallace Dana , Bedbrook Anna , Czarlewski Wienczyslawa , Bousquet Jean
Published: December 2020

A iniciativa Allergic Rhinitis and Its Impact on Asthma (ARIA) teve início há mais de 20 anos e tem elaborado e disseminado orientações baseadas em evidência, e desenvolvido projetos na área da rinite alérgica. Esta iniciativa está atualmente focada em proporcionar orientações centradas no doente que contribuam para um percurso integrado entre os vários níveis de cuidados e que tirem partido de soluções digitais, tendo sido recomendada a introdução na prática clínica de percursos assistenciais integrados. Neste artigo descrevemos a adaptação para Portugal do documento ARIA Integrated Care Pathways. Após breve revisão sobre a epidemiologia e o impacto da rinite alérgica em Portugal e das atividades realizadas em Portugal no âmbito da iniciativa ARIA, é descrito o conjunto alargado de conhecimento utilizado para o desenvolvimento das recomendações para o tratamento farmacológico da rinite alérgica, recomendações essas baseadas na metodologia GRADE, evidência do mundo real adquirida por tecnologia móvel (mHealth) e resultante de estudos de câmara de exposição alergénica. Em seguida, são resumidos os percursos assistenciais integrados para imunoterapia com alergénios produzidas em 2019. Considera-se a imunoterapia com alergénios um exemplo de medicina de precisão e em que a utilização de tecnologias mHealth permitirá melhorar a estratificação para seleção dos doentes e monitorização da resposta. Estas recomendações foram consideradas como ‘boas práticas’ dos cuidados integrados centrados no doente apoiados por sistemas digitais da DG Santé (Direção Geral de Saúde e de Segurança Alimentar da União Europeia) e representam a estratégia de gestão da mudança da fase 4 do ARIA.
valorização da sociobiodiversidade na alimentação escolar
Authors: Brito Tayrine Parreira , Rocha Luiz Carlos Dias da , Hirata Aloísia Rodrigues , Raimundo Rogério Robs Fanti , Galvão Lívia Oliveira
Published: December 2020

O objetivo do trabalho foi investigar a realidade da inserção dos alimentos da sóciobiodiversidade na alimentação escolar das escolas públicas do estado de Minas Gerais e sua relação com as questões ambientais. Tratou-se de uma pesquisa documental de abordagem qualitativa e os materiais de investigação foram as sistematizações elaboradas pelo CECANE IFSULDEMINAS no produto das Oficinas Regionais realizadas em 2018. As oficinas foram realizadas em diferentes regiões do estado, nos municípios de Lavras, Boa Esperança, Bambuí, Uberlândia e Pompéu. Foi constatado um total de 73 itens alimentares diferentes, destes 15 são considerados nativos dos biomas brasileiros e seis Plantas Alimentícias Não Convencionais (PANCs). O resultado do levantamento feito nas oficinas demonstrou pouca diversidade alimentar nos cardápios escolares, sendo que 26 itens foram citados em todas oficinas. Este padrão alimentar é preocupante do ponto de vista ambiental, uma vez que está restrito a poucas espécies de plantas. Por outro lado, o Brasil é um país de grande riqueza biológica, com muitas espécies consideradas propícias para a alimentação humana, onde a simbiose entre homem e natureza acontece nos processos de sociobiodiversidade, um potencial a ser valorizado, em que a escola aparece como um mecanismo estratégico de incentivo.
A Transição de Carreira de Executivos Seniores para Carreira Empreendedora
Authors: Neves Mônica Maria , Trevisan Wilson , Petrokas Leandro Augusto
Published: December 2020

A proposta deste artigo foi verificar se há relação entre a decisão de empreender do executivo sênior com a âncora de carreira criatividade empreendedora, uma das oito “Âncoras de Carreira” propostas por Schein (1996). Foi utilizada uma amostra intencional de indivíduos que passaram por um processo de orientação de carreira pela empresa de consultoria DBM e tomaram a decisão de empreender. O estudo fundamentou-se na dificuldade que o profissional sênior, acima de 50 anos, encontra para se recolocar no mercado formal de trabalho, fazendo com que ele avalie outras opções de carreira, dentre elas o empreendedorismo. Por meio da análise dos resultados das “Âncoras de Carreira” destes indivíduos, obtidas por ocasião do processo de orientação de carreira na consultoria DBM, foi avaliada a convergência de opiniões em relação às oito âncoras e se houve incidência maior na âncora que avalia a criatividade empreendedora. Os resultados mostraram que há predomínio da âncora criatividade empreendedora para os profissionais que optaram por negócio próprio e também da âncora técnica funcional e gerência geral o que pode indicar a influência do ambiente corporativo na trajetória profissional destes indivíduos.
GESTÃO DE PESSOAS POR COMPETÊNCIAS: AVALIAÇÃO DE UM MODELO IMPLEMENTADO NUMA ORGANIZAÇÃO DO SETOR PETROQUÍMICO
Authors: Santos Heliani Berlato dos , Costa Luciano Venelli , Hipólito José Antonio Monteiro , Guedes Simone
Published: December 2020

Este artigo propõe-se a estudar o caso de uma empresa brasileira do setor petroquímico, que implementou um modelo de gestão por competências no ano de 2001. O objetivo do estudo foi avaliar em que grau as mudanças no ambiente da indústria petroquímica, implicaram na necessidade de substituição ou revisão do modelo, bem como analisar sua eficácia na gestão de carreiras – dimensão central na operacionalização de um modelo de gestão por competências. A pesquisa baseou-se em levantamento de dados por fontes secundárias e entrevistas semi-estruturadas com dez funcionários da empresa, nos níveis de coordenação, gerência, diretoria e também da área de Recursos Humanos. Em linhas gerais, pôde-se constatar que o modelo continua adequado para o período atual, porém há a necessidade de ajustes pontuais para adequá-lo às mudanças organizacionais. Merece destaque a importância da capacitação dos funcionários e gestores para o melhor aproveitamento do modelo e das oportunidades de desenvolvimento existentes. Os resultados obtidos com este estudo podem ser úteis para consolidar o entendimento sobre a aplicação do modelo de gestão por competências, bem como para subsidiar a reflexão de organizações em cenários similares sobre os pontos de atenção na consolidação de novos modelos de Gestão de Pessoas.
THE USE OF CATEGORIES AS INDICATORS OF ORGANIZATIONAL CLIMATE IN BRAZILIAN COMPANIES
Authors: Dutra Joel Souza , Fischer André Luiz , Nakata Lina Eiko , Pereira Julio Cesar Rodrigues , Veloso Elza Fátima Rosa
Published: December 2020

In order to analyze employees’ perception of the work environment, companies with a well-established people management structure periodically conduct organizational climate surveys. These surveys are meant to offer an understanding of how employees view the quality of the relationships they experience in the company. One of the characteristics of this type of survey, identified both in the relevant literature and empirically in practice, is the use of categories or indicators to direct development of the research instrument, data analysis, and later intervention as needed according to the results of the survey. This article seeks to propose a categorization of organizational climate dimensions directed at the Brazilian corporate reality, analysing its internal consistency and its construct validity. To that end, we used the results of a wide-ranging data sample collected from 123,445 respondents of 491 organizations in various regions of Brazil. The proposed analysis categories – identity, satisfaction and motivation, learning and development, and leadership – were reviewed based on theories of organizational behavior and then submitted to a focus group composed of human resources professionals employed by prominent Brazilian corporations.
Dissecting the Roles of Cuticular Wax in Plant Resistance to Shoot Dehydration and Low-Temperature Stress in Arabidopsis
Authors: Rahman Tawhidur , Shao Mingxuan , Pahari Shankar , Venglat Prakash , Soolanayakanahally Raju , Qiu Xiao , Rahman Abidur , Tanino Karen
Published: December 2020

Cuticular waxes are a mixture of hydrophobic very-long-chain fatty acids and their derivatives accumulated in the plant cuticle. Most studies define the role of cuticular wax largely based on reducing non-stomatal water loss. The present study investigated the role of cuticular wax in reducing both low-temperature and dehydration stress in plants using Arabidopsis thaliana mutants and transgenic genotypes altered in the formation of cuticular wax. cer3-6, a known Arabidopsis wax-deficient mutant (with distinct reduction in aldehydes, n-alkanes, secondary n-alcohols, and ketones compared to wild type (WT)), was most sensitive to water loss; while dewax, a known wax overproducer (greater alkanes and ketones compared to WT), was more resistant to dehydration compared to WT. Furthermore, cold-acclimated cer3-6 froze at warmer temperatures, while cold-acclimated dewax displayed freezing exotherms at colder temperatures compared to WT. GC-MS analysis identified a characteristic decrease in the accumulation of certain waxes (e.g. alkanes, alcohols) in Arabidopsis cuticles under cold acclimation, which was additionally reduced in cer3-6. Conversely, the dewax mutant showed a greater ability to accumulate waxes under cold acclimation. FTIR spectroscopy also supported observations in cuticular wax deposition under cold acclimation. Our data indicate cuticular alkane waxes along with alcohols and fatty acids can facilitate avoidance of both ice formation and leaf water loss under dehydration stress, and are promising genetic targets of interest.
Mitophagy and the Brain
Authors: Swerdlow Natalie , Wilkins Heather
Published: December 2020

Stress mechanisms have long been associated with neuronal loss and neurodegenerative diseases. The origin of cell stress and neuronal loss likely stems from multiple pathways. These include (but are not limited to) bioenergetic failure, neuroinflammation, and loss of proteostasis. Cells have adapted compensatory mechanisms to overcome stress and circumvent death. One mechanism is mitophagy. Recent studies have implicated mitophagy in several neurodegenerative diseases and clinical trials are underway which target mitophagy pathways. Here, we review mitophagy pathways, the role of mitophagy in neurodegeneration, potential therapeutics, and the need for further study.
Multivariate Analysis of Structural and Functional Neuroimaging Can Inform Psychiatric Differential Diagnosis
Authors: Stoyanov Drozdstoy , Kandilarova Sevdalina , Aryutova Katrin , Paunova Rositsa , Todeva-Radneva Anna , Latypova Adeliya , Kherif Ferath
Published: December 2020

In order to overcome this problem our group designed a novel machine learning technique, multivariate linear method (MLM) which can capture convergent data from voxel-based morphometry, functional resting state and task-related neuroimaging and the relevant clinical measures. In this paper we report results from convergent cross-validation of biological signatures of disease in a sample of patients with schizophrenia as compared to depression. Our model provides evidence that the combination of the neuroimaging and clinical data in MLM analysis can inform the differential diagnosis in terms of incremental validity to reach 90 % accuracy of the prediction.
Ligand Docking Methods to Recognize Allosteric Inhibitors for G-protein Coupled Receptors
Authors: Harini K , Jayashree S , Tiwari Vikas , Vishwanath Sneha , Sowdhamini Ramanathan
Published: December 2020

G-protein coupled receptors (GPCRs) are large protein families known to be important in many cellular processes. They are well known for their allosteric activation mechanisms. They are drug targets for several FDA-approved drugs. We have investigated the diversity of the ligand binding site for these class of proteins against their cognate ligands using computational docking, even if their structures are known in the ligand-complexed form. The cognate ligand of some of these receptors dock at allosteric binding site, with better score than the binding at the conservative site. Further, ligands obtained from GLASS database, which consists of experimentally verified GPCR ligands, also show allosteric binding to GPCRs. The allosteric binders show strong affinity to the binding site, though the residues at the binding site are not conserved across GPCR subfamilies.
Monolithic Solvers for Incompressible Two-Phase Flows at Large Density and Viscosity Ratios
Authors: EL OUAFA Mohamed , vincent stephane , Le Chenadec Vincent
Published: December 2020

In this paper, we investigate the accuracy and robustness of three classes of methods for solving two-phase incompressible flows on a staggered grid. Here, the unsteady two-phase flow equations are simulated by finite volumes and penalty methods using implicit and monolithic approaches (such as the augmented Lagrangian and the fully coupled methods), where all velocity components and pressure variables are solved simultaneously (as opposed to segregated methods). The interface tracking is performed with a Volume-of-Fluid (VOF) method, using the Piecewise Linear Interface Construction (PLIC) technique. The home code Fugu is used for implementing the various methods. Our target application is the simulation of two-phase flows at high density and viscosity ratios, which are known to be challenging to simulate. The resulting strategies of monolithic approaches will be proven to be considerably better suited for these two-phase cases, they also allow to use larger time step than segregated methods.
Web-based Tools for Computational Enzyme Design
Authors: Marques Sérgio M. , Planas-Iglesias Joan , Damborsky Jiri
Published: December 2020

Enzymes are on high demand for very diverse biotechnological applications. However, natural biocatalysts often need to be engineered for fine-tuning their properties towards the end applications, such as the activity, selectivity, stability to temperature or co-solvents, and solubility. Computational methods are increasingly used in this task, providing predictions that narrow down the space of possible mutations significantly and can enormously reduce the experimental burden. Many computational tools are available as web-based platforms, making them accessible to non-expert users. These platforms are typically user-friendly, contain walk-throughs, and do not require deep expertise and installations. Here we describe some of the most recent outstanding web-tools for enzyme engineering and formulate future perspectives in this field.
Clinical Trial on Solid 2nd Generation Platelet-Concentrates in the Management of the Chronic Osteomyelitis: A Advanced Regenerative Surgeries
Authors: Crisci Alessandro , D'Adamo Raffaele , Crisci Michela
Published: December 2020

The supposition is that the usage of fibrin rich in leukocytes and platelets advanced (A-PRF) in ulcerative osteomyelitis of the diabetic foot allows rehabilitation from this critical illness. In this investigation, the focus was to normalize the use of PRF in patients with osteomyelitis not amputated, to use this second generation platelet concentrate as a regeneration enabler. The researchers submitted and utilized A-PRF membranes (1300 g × 8 min) in 7 patients (all diabetics) with osteomyelitis and cutaneous injury for 6 months. The membranes, in combination with the supernatant fluid produced by stress, have been integrated into the skin lesion down to the bone after surgical debridement. The advancement of the lesions after some period of time has been analyzed. All seven subjects had a Probe-to-Bone positive assay; MRI indicated a cortico-periosteal coagulation and/or foci of cortico-spongeous osteolysis contiguous to the lesion. Gram-positive bacterium were identified in our procedures in 52% of cases. Gram+ Cocci, for example, S. Aureus (15.6%), S. Hemolytic (12.1%), S. Viridans (7.1%), and Gram-negative Bacteria, for example, Pseudomonas (10.6%), Proteus (7.8%), Enterobacter (5.7%) are present. Candida Albicans is active in 2.8%. The blood count shows no relevant differences. To date, cutaneous lesions have cured in 6 of the seven subjects treated (one patient for more than five years) without any evidence of infection or recurrence. The results obtained on our subjects indicate that PRF membranes may be a therapeutic option in this problematic disease.