bluuebunny/crossref_metadata_2025 huggingface dataset:
Emerging Role of Immune Checkpoint Inhibitors in Hepatocellular Carcinoma
Authors: Longo Vito , Brunetti Oronzo , Gnoni Antonio , Licchetta Antonella , Del Curatolo Sabina , Memeo Riccardo , Solimando Antonio Giovanni , Argentiero Antonella
Published: September 2019

Hepatocellular carcinoma is the most common primary liver cancer and the fourth leading cause of cancer death worldwide. A total of 70-80% of patients are diagnosed at an advanced stage with a dismal prognosis. Sorafenib has been the standard of care for almost a decade until 2018 when FDA approved an alternative first-line agent namely lenvatinib. Whereas FOLFOX4 results an alternative first-line treatment for the chinese clinical oncology guidelines. In addition to cabozantinib, regorafenib, and ramucirumab, two therapeutics against the PD-L1/PD1 axis have been recently approved for subsequent-line therapy, as nivolumab and pembrolizumab. However, similar to other solid tumors, the response rate of single-agent targeting PD-L1/PD1 axis is low. Therefore a lot of combinatory approaches are under investigation, including the combination of different immune checkpoint inhibitors, the addition of immune checkpoint inhibitors after resection or during locoregional therapy, immune checkpoint inhibitors in addition to kinase inhibitors, anti-angiogenic therapeutics, and others. This review focuses on the use of ICIs for the hepatocellular carcinoma with an attent evaluation of new ICIs based combinatory approaches.
Comparative Extraction Efficacy of Different Organic Solvents for Leaf Chlorophylls and Carotenoids in (Portulaca oleracea L.) Varying with Growth Behavior and Stress Type
Authors: Ahmadi Khadijeh , Omidi Heshmat , Mehrnia Mohsen , Ur Rehman Hafeez
Published: September 2019

The chlorophyll is one of the most important natural pigments used extensively in the food industry. Two important factors for the production of chlorophyll are the use of plants rich in chlorophyll and efficiency of extraction method. Present investigation was performed to compare the extraction of photosynthetic pigments by using solvents of different chemical nature. The purslane plants with different growth behavior viz. Scrollable and standing were grown under shade and sunshine stress condition. Different solvents including diethyl ether, 5% ethanol, pure acetone, 20% acetone, pure methanol and 10% methanol were used to extract chlorophyll and carotenoids from the purslane plant. The results indicated that stress, growth type and different solvents had a significant effect on the extraction of chlorophyll and carotenoids. Different trend was observed in extraction rate for chlorophylls and carotenoids. Among the solvents, pure methanol was the best for extraction of chl a. Methanol and acetone were appropriate solvents to achieve the highest amount of chlorophyll from plant tissues. Among different solvents, pure methanol for chl a, pure acetone and methanol for carotenoids were best solvent for purslane plant with a growing type scrollable of under shade.
Spatial Analysis of Curb-Park Violations and Their Relationship with Points of Interest: A Case Study of Tehran, Iran
Authors: Koohpayma Javad , Tahooni Amir , Jelokhni Mohammad reza , Jokar Arsanjani Jamal
Published: September 2019

Car parking is a challenging part of urban transportation and the traffic violations around it cause many problems for citizens. In recent years, due to the fast growth and development of urbanization, temporary and unauthorized stopping of cars along the streets, especially in large cities, has led to an increased traffic, urban disorders, dangers for citizens, and violation of rules. Studies have shown that there is a direct relationship between vehicle parking violations and urban places. GIScience capabilities and tools play an important role in analysing the spatial distribution of these violations. In this study, we investigated the spatial distribution of vehicle violations in a region of Tehran, Iran that is suffering from a heavy traffic load and heavily polluted air. Although two dissimilar urban segregations exist in the north and south of the study area, our analysis indicates a similar pattern of car parking violations. In both of the areas, about 70% of all curb parks are legal, while the remaining are illegal. Also, spatial analysis reveals a direct relationship between some POIs and the occurrence of car park violations so that the density of legal curb parks is high near some POIs, and less near some others and vice versa. For example, the number of vehicle park violation around the hospitals is more than the average of the study area. However, the number of park violations around the universities is less than the average. Our findings reveal that co-location of certain POIs, for instance a hotel and a supermarket will lead to an increase in the number of park violations. In other words, there is a strong correlation between the type of POIs and curb-parks violations. Our results also show that POIs have an impact radius that leads to violations occurring in that area. For example, the area of the impact of a hospital on the creation of car park violations was estimated at 125 meters. Our presented approach along with the discussed findings along with conclusions can be useful to a large range of stakeholders including urban planner, traffic police departments, local municipalities, law enforcement agencies, and environmentalists to have a better perspective of infrastructure planning.
A QUBO Model for the Traveling Salesman Problem with Time Windows for Execution on the D-Wave
Authors: Papalitsas Christos , Andronikos Theodore , Giannakis Konstantinos , Theocharopoulou Georgia , Fanarioti Sofia
Published: September 2019

This work focuses on expressing the TSP with Time Windows (TSPTW for short) as a quadratic unconstrained binary optimization (QUBO) problem. The time windows impose time constraints that a feasible solution must satisfy. These take the form of inequality constraints, which are known to be particularly difficult to articulate within the QUBO framework. This is, we believe, the first time this major obstacle is overcome and the TSPTW is cast in the QUBO formulation. We have every reason to anticipate that this development will lead to the actual execution of small scale TSPTW instances on the D-Wave platform.
The Protective Role of Toll-like Receptors Agonist Monophosphoryl Lipid A against Vaccinated Murine Schistosomiasis
Authors: Aly Ibrahim , Ibrahim Essam H. , Hamad Rabab S. , Sayed Hoda EL , Attiyah Sama M.N. , E-Komy Wafaa , Ghramh Hamed A. , Alshehri Ali , Alsyaad Khalid M. , Alshehri Mohammed , Kilany Mona
Published: September 2019

Schistosomiasis, a crippling ailment that afflicts over 220 million people worldwide. Yet or up till now, there is no vaccine for schistosomiasis, and chemotherapy relies heavily on a single drug, the praziquantel. The present study was undertaken to investigate the therapeutic effect of Monophosphoryl Lipid A (MPLA) as an adjuvant in soluble egg antigen (SEA) vaccinated mice against the deleterious pathological impacts induced in hepatic tissues of mice by Schistosoma mansoni infection. In addition, to study the associated parasitological, immunological and biochemical parameters. Parasitological parameters showed that intraperitoneal injection of MPLA into SEA-vaccinated and S. mansoni-infected mice was effective to a significant degree in reducing the worm and egg burden, granuloma count and diameter as well as the total area of infection in their livers versus SEA-untreated but infected ones. In addition, MPLA showed ameliorative action on the elevated liver oxidative stress marker, including malondialdehyde (MDA) and decrease in the level of the antioxidant enzymes, reduced glutathione (GSH) and catalase (CAT) which may have a role in the liver damage and fibrosis due to S. mansoni infection. In conclusion, treatment with MPLA has multi-functions in attenuating the deleterious impacts of S. mansoni infection in mice livers. Its effects are mediated through a reduction of ova count, worm burden, granuloma diameter and amelioration of antioxidant defense systems, and liver function biomarkers.
PENINGKATAN DAYA JUAL ANEKA PRODUK OLAHAN MAKANAN MELALUI TEKNIK PENGEMASAN PRODUK
Authors: Hidayat Yuniawan , Triharyanto Eddy
Published: September 2019

Desa Jendi dan Desa Keloran, Wonogiri merupakan desa yang
memproduksi aneka keripik hasil pertanian. Di Desa Jendi terdapat
Lembaga Pemberdayaan Kesejahteraan Keluarga (LPKK) Putri Mandiri
yang memproduksi berbagai keripik seperti keripik tempe dan keripik
singkong. Di Desa Keloran terdapat LPKK Sumber Rejeki yang
memproduksi keripik singkong yang telah dipresto terlebih dahulu.
Permintaan keripik singkong di kedua mitra semakin meningkat. Akan
tetapi, kemasan yang digunakan masih sangat sederhana. Kemasan saat
ini masih menggunakan plastik yang diberi label. Padahal untuk
menunjang pemasaran, kemasan harus dibuat semenarik mungkin.
Tujuan dari pengabdian ini adalah untuk meningkatkan kualitas
kemasan agar dapat dipasarkan di pusat oleh-oleh dan menjadi produk
unggulan Wonogiri serta melatih para anggota-anggota LPKK mengenai
pemasaran produk. Oleh karena itu, tim pengabdi memberikan solusi
berupa pemberian Teknologi Tepat Guna kepada kedua mitra. Teknologi
Tepat Guna tersebut adalah Hand Sealer, Cup Sealer, Spinner dan Dus
Kemasan. Selain pemberian TTG, dilakukan pula pelatihan inclass
mengenai manajemen keuangan, pengemasan dan manajemen
pemasaran.
PENGEMASAN PRODUK WISATA OLEH POKDARWIS SEBAGAI SALAH SATU MODEL PARIWISATA ALTERNATIF
Authors: Andiani Nyoman Dini , Widyastini Ni Made Ary
Published: September 2019

A Conscious Tourism Group in Indonesia called Kelompok Sadar Wisata (Pokdarwis) is one of the groups in society that has an important role and contribution in tourism development in a region. The existence of Pokdarwis in the tourist destination should get support and guidance either by the community itself, government, academy and investors. This is so that Pokdarwis can play a more effective role in helping to mobilize the community in realizing the environment and atmosphere that is conducive to the growth and development of tourism activities in tourist destinations. Buleleng District there are 12 Pokdarwis which in practice still needs to get attention from various parties. On this occasion, the Ipteks for Society (IbM) program, which is an annual program implemented by a university, can be a means of providing services to the community regarding issues that arise in the group. Through this IbM program, two Pokdarwis, such as Pokdarwis Tunjung Mekar and Pokdarwis Bhuana Shanti, have just developed physical potential, requiring assistance and training to maximize the potential of their village. In this case the two groups are not well understood for the package tour, so based on the condition, IbM's programme is a means to arrange the community to create package including marketing strategies. Understood the disadvantages of guiding guides that guide travelers who ask them to use a foreign language, then the IbM program is created guidebook in two languages and Indonesian. Through participatory approaches various forms of training and guidance on how to package tourism, holiday techniques and marketing strategies can be done well.

Keywords: Pokdarwis, Training, Package Tour, Tourist Guidelines Book, Marketing Strategy.
PENDIDIKAN DAN LATIHAN AKUNTANSI BAGI PELAJAR DAN MAHASISWA MELALUI PPUPIK PUSAT PELATIHAN AKUNTANSI UNIVERSITAS PGRI PALEMBANG
Authors: Zahruddin Zahruddin
Published: September 2019

Accounting education and training for students and college through PPUPIK,target this Accounting Training Center at the University of Palembang PGRI have 4,there are Senior high school / Islamic School students, vocational students, college and the general public. Accounting training is implemented in theory and practice, both accounting and computer accounting. The recognition system has been carried out by

involving college of Edu Accounting Ambassadors and Accounting Education study program by visiting schools and campuses in Palembang to promote and / or establish cooperation. The activities were also published in the mass media, online and newspapers. The implementation of the activities that have been done with two classes, morning study class at 08.00 a.m- 12.00 a.m., afternoon study class is 12.00 a.m- 16.00 p.m. Accounting training conducted is divided into 4 classes, there are service company accounting, trading company accounting, manufacturing accounting and computer accounting (MYOB and Accurate). In phase 1 (February - March 2018) there were 149 participants from Senior high school, vocational School and Islamic School students, on phase 2 (May - June 2018) the participants were students from various universities totaling 149 people and on phase 3 (August - September 2018) the participants were 50 Senior high school, vocational School and Islamic School students. After studying 12-16 meetings, the final examination is conducted for those who have passed the certificate given. For teacher, besides the lecturer in Accounting Education Study Program and lecturer in Accounting Study ProgramUniversity of PGRI Palembang, and also involves brainy alumni . Teachers who come from partners are Prospect accounting courses. Guest lecturers are invited to public lectures and supplements.
Keywords: Accounting, Training, Theory and Practice
PENGARUH VALUE CONGRUENCE DAN CORE SELF-EVALUATIONS TERHADAP JOB ENGAGEMENT DAN DAMPAKNYA PADA ORGANIZATIONAL CITIZENSHIP BEHAVIOR
Authors: Kurniawan Ignatius Soni
Published: September 2019

SMEs in Kasongan Bantul have a good reputation as SMEs that are able to penetrate in foreign markets. How OCB and Employee JE formed so that it can pull SMEs performance is the main issue being discussed in this research. Asking for 107 employees of SMEs in Kasongan craft industry bantul to fill in the questionnaire, this research can prove that value congruence directly or indirectly affects employee JE on OCB. Unfortunately, this research is unable to prove the effect of CSE on OCB direcly or indirecly.
Keywords: value congruence, core self-evaluations, job engagement, organizational citizenship behavior.
ALIH TEKNOLOGI PENGELOLAAN LIMBAH TERNAK BAGI UMKM MIKRO PETERNAK SAPI
Authors: Juli Rachmawatie Srie , Rachmawati Dewi Riana , Rosana Dewi Tria
Published: September 2019

There are still many cattle farmers in the village of Mayang who do not understand the importance of technology transfer to manage livestock waste in the form of solid and liquid. This should begin to be considered given the business location is in a densely populated area. Livestock waste in the form of liquid is still simply taken in the morning to be used as a pesticide, but the solid one is only thrown behind the cage location. Waste treatment is important because it can provide benefits for partners especially and surrounding communities. Technology transfer with degester is used as an alternative solution including biogas waste. Training on technology utilization and impact management is done so that people understand the importance of using technology facilities in the current era. Finally partners can enjoy the benefits provided in managing waste, namely biogas for the home industry and financial management. The repaired enclosure can be used effectively and efficiently because the waste enters the degester installation without needing to be cleaned traditionally and saves maintenance costs.
PERAN MEDIASI CAPAIAN FINANSIAL: PRAKTEK MANAJEMEN KEUANGAN DAN KEPUASAN FINANSIAL PEDAGANG BATIK DAN SOUVENIR DI PASAR BERINGHARJO YOGYAKARTA
Authors: Rinofah Risal , Sari Pristin Prima
Published: September 2019

This study aims to investigate the mediation role of financial experience on the link between financial management practice and financial satisfaction of Small Business Enterprise (SME) in Beringharjo Market in Yogyakarta. This study uses primary data and random sampling. This Study uses questionairre with likert scale. This study collects data to respondent in Beringharjo Market of Yogyakarta Special Region. The result of this study is financial experience can be mediator in the link between financial management practice and financial satisfaction. This study can be used to campaign financial management practice to small busniess entreprise (SME), to develop small business entreprise (SME), to make decision in business especially small business entreprise (SME).

Keyword : Financial management practice, financial experience, financial satisfaction, SME, Beringharjo Market
PROSPEK PENGEMBANGAN ES GABUS BUAH DAN SAYUR, CITA RASA JADUL KAYA VITAMIN
Authors: Mulya Astuti Zenita , Abdi Nusara Anindya , Vidya Anggraini Cisya , Wandhira Wimarnaya Viska , Fadhila Nurul , Yudhistira Bara
Published: September 2019

In this modern era, many snacks that are not safe for health are sold to children and they like them very much. This problem is very serious to note because it is related to children's health. To overcome or reduce this problem, created an innovation of healthy snacks that are rich in vitamins, namely Ice Cork Fruit and Vegetables from various types of vegetables such as carrots, mustard greens, and purple yams. Ice Cork Vegetables are made with the aim of increasing interest in vegetable consumption in children. The target is to attract the interest of children to eat delicious snacks, safe and healthy through EGAYUR (VEGE ICE). Because in general children like to eat snacks that are tasty and refreshing, cork ice for example. The method for realizing this idea is to create an entrepreneurial business program that produces EGAYUR (VEGE ICE). The first thing to do is to make an SOP for making EGAYUR (VEGE ICE). Then do the trial making of EGAYUR (VEGE ICE) products, do research on the taste variants that consumers like, then do the production process. In one production it will produce 75 products, which are done once a week for 4 months. So that the total production for one month is 75 products.

Keywords : ice cork, vegetables, vitamins 
Randomized controlled trial on the effect of YouTube surgical videos on procedural knowledge and perceived self-efficacy of surgery residents
Authors: Albarrak Abdullah Ahmed S , Alnefaie Faisal A , Almasoud Riyadh
Published: September 2019

Background Multiple factors have challenged the surgical training which led to the development of the instructional videos to hasten the proficiency in performing surgical procedures. However, their educational effect has not been objectively studied yet. This study aims at objectively assessing the effect of instructional videos along with the subjective assessment of the self-efficacy of the training residents. The videos used were selected from YouTube, which is a valuable resource currently because of its ubiquitous availability and cost effectiveness. Methods A stratified randomized controlled trial was performed using an objective assessment tool for the procedural knowledge along with a questionnaire to assess the effect of videos on the perceived self-efficacy of the residents. Results There was a significant positive effect of watching instructional videos on the procedural knowledge. Even though residents report positive experience with using the videos, there was no significant effect of videos on the self-efficacy scores as reported by the residents. Conclusion instructional videos improved the procedural knowledge of the residents. This positive observation of the use of the YouTube videos offers great opportunities for the educationalists to select from thousands of videos instead of making the videos themselves.
Effects of blended versus offline case-centered learning on academic performance and the development of critical thinking among undergraduate nursing students
Authors: Yu Zhenzhen , Shen Ling , Zhuang Jiayuan , Chen Yimin , Chen Meijing , Lin Yazhu , Hu Rong
Published: September 2019

Background Educational reform, especially methods of teaching, has been a focus among nursing educators. This study explored the impact of blended versus offline case-centered learning on academic performance and the development of critical thinking among undergraduate nursing students.Methods A total of 269 undergraduate nursing students in two classes were taught Medical Nursing for 1 year. The two classes were randomly allocated to the experimental group (151 students), which undertook blended learning, or the control group (118 students), which undertook offline learning. The primary outcomes were academic performance and critical thinking ability. The Critical Thinking Disposition Inventory-Chinese Version (CTDI-CV) was used.Results At baseline, the students in the control group exhibited superior performance to that observed in the experimental group regarding all seven Professional Basic courses. There was no significant difference in academic performance in the Medical Nursing course after applying the two teaching methods; however, the median score was slightly higher in the experimental group than in the control group. In addition, there was no significant difference in the development of critical thinking ability between the blended and offline learning groups. In the experimental group, there was significant improvement compared with baseline in one of the seven CTDI-CV dimensions: critical thinking self-confidence (p<0.05). In the control group, there was significant improvement compared with baseline in the total score (p<0.05) and two of the seven dimensions: truth-seeking (p=0.001) and systematicity (p=0.010).Conclusions Our study confirms the effectiveness of blended and offline learning (both based on case-centered learning) for academic performance and components of critical thinking among undergraduate nursing students. Blended and offline case-centered learning should be applied to other nursing subjects in future studies. Moreover, further efforts to improve teaching are warranted.
In silico Analysis of CadF epitope- based vaccine design against Campylobacter jejuni
Authors: Naseri Mona Mobalegh , Shams Saeed , Naseri Mohammad Moballegh , Bakhshi Bita
Published: September 2019

Background

To eradicate infectious diseases caused by microorganisms, vaccination is a popular strategy against them and can be an effective approach. Among vaccines, subunit vaccines have been used to be more effective against diseases. CadF protein of Campylobacter jejuni is one of the important antigens in the pathogenic process of the bacterium. So, the aim of this work was to do a bioinformatics study for the identification of epitope-based CadF vaccine, as a subunit vaccine.

Main body

CadF gene sequences were extracted from the NCBI database and suitable physic-chemical properties of CadF were evaluated by Protprom server. Some epitopes of the CadF protein with high affinity were detected by different servers, which were predicted based on MHC-peptide complex and B-cell epitopes. The results indicated that CadF is an antigenic and non-allergenic protein and provided a desirable structure for design vaccine. Among epitopes, LSDSLALRL was confirmed for the simulation of both of B and T cells. This 9-mers peptide was located in 135-143 sequences of CadF protein and interacted with HLA-A0101. The peptide isn’t allergen and has the ability to be an antigen for motivating immune system. Besides, the analysis implied that the epitope structure could allow designing a vaccine against C. jejuni.
Co-infection of Anaplasma and Ehrlichia in Hedgehogs from China.
Authors: Xiao Xiao , Han Hui-Ju , Qi Rui , Gong Xiao-Qing , Lei Si-Cong , Liu Jian-Wei , Qin Xiang-Rong , Zhou Chuan-Min , Fang Li-Zhu , Ma Xiao-Juan , Chu Min , Yu Xue-Jie
Published: September 2019

Hedgehogs ( Erinaceus amurensis ) is an insectivorous mammal frequently observed in the wild and around the residential areas. However, information about tick-borne diseases in this species is not well known. We investigated tick-borne rickettsial pathogens including Anaplasma , Ehrlichia, Candidatus . Neoehrlichia and Rickettsia in hedgehogs collected in central China. Hedgehogs were captured from Hubei and Jiangxi Province with living traps. PCR amplification and DNA sequencing showed that 26% (19/73) hedgehogs were positive to Anaplasma bovis, 20.5% (15/73) were positive to a tentative new Ehrlichia species; in addition, 13.7% (10/73) hedgehogs were positive to A. bovis and Ehrlichia simultaneously. Ca . Neoehrlichia and Rickettsia species was not detected among the 73 hedgehogs. We concluded that hedgehogs from central China were widely infected with Anaplasma and Ehrlichia , suggesting hedgehogs may play a role in the ecology of Anaplasma and Ehrlichia .
Biomarkers of early cardiovascular aging
Authors: Groznova O. S. , Miklashevich I. M. , Voinova V. Yu. , Shkolnikova M. A. , Tkacheva O. N. , Dudinskaya E. N. , Kovalev I. A.
Published: September 2019

Genetic aspects regulate the intensity and rate of aging (no toxic effects considered), their negative role depends on the pathogenicity of the mutation. The light variant of the genetic “defect” has no clinical signs which feature a certain known genetic syndrome, but it has the biochemical, immunological, vascular and other abnormalities leading to pathological aging. In the most severe case, e.g. progeria, pathological aging is the main phenotypic symptom that manifests already in childhood. The subject of the pathological aging research covers the whole range of intermediate states. The review focuses on aging in individuals without validated signs of disease: coronary heart disease, hypertension, diabetes or fasting hyperglycemia, hyperlipidemia, and others. The authors present the main searching directions of aging biomarkers (size and speed of telomere shortening, breaks in their terminal loops; expression of inflammatory proteins, synaptic interactions proteins and neurotrophic processes; mitochondrial biogenesis; endothelial dysfunction; DNA methylation activity).
Pre-eclampsia in a mother and programming of the child’s cardiovascular health
Authors: Kovtun O. P. , Tsyvian P. B.
Published: September 2019

The authors present a review of the literature devoted to the problem of programming the formation of the cardiovascular system structure and function in children born from mothers with preeclampsia. These children are at high risk of developing cardiovascular diseases. Pre-eclampsia is caused by the endothelium dysfunction, deregulation of the immune and inflammatory factors during pregnancy. Experimental studies identify these factors as key epigenetic factors programming the condition of the cardiovascular system of the offspring. The modern concept of intrauterine programming, describing this phenomenon, focuses on three main areas of research: experimental models simulating the intrauterine environment with preeclampsia; research of the pathological phenotype formation under the influence of these factors; epigenetic studies of the influence of preeclampsia on the cardiovascular system functioning. The article discusses the perspectives of epigenetic programming prevention.
Therapeutic effect of human umbilical cord-derived multipotent mesenchymal stromal cells in a patient with Crigler–Najjar syndrome type I
Authors: Sukhikh G. T. , Degtyareva A. V. , Silachev D. N. , Gorunov K. V. , Dubrovina I. V. , Ushakova L. V. , Degtyarev D. N.
Published: September 2019

The article presents the results of intravenous transplantation of allogeneic multipotent mesenchymal stromal cells, derived from a human umbilical cord, to a child with Crigler–Najjarsyndrome type I during the first 2 years of life. The therapy is aimed at reduction of the duration of phototherapy while maintaining a safe level of serum bilirubin.

In this study, a five-day-old child with the bilirubin level of 340 µmol/l was treated with phototherapy for 16–18 hours daily in the neonatal period. Then, phototherapy was reduced to 14–16 hours. The level of bilirubin varied from 329 to 407 μmol/l. At the age of 2 months, it was decided to use multipotent mesenchymal stromal cells with a significant decrease in the duration of phototherapy up to 2 hours a day. During the observation period (2 years at the time of writing this article) the child received 6 injections of multipotent mesenchymal stromal cells. A positive effect developed within 4–7 days after administration and persisted for 2–3 months. There were no side effects or complications during and after transplantation.

Thus, intravenous transplantation of multipotent mesenchymal stromal cells is an effective treatment of Crigler–Najjar syndrome type I; it reducesthe need for phototherapy,significantly improvesthe quality of life of the patients and prolongstheir life with native liver.
Features of the state of newborns born to underage mothers
Authors: Mikhailin E. S. , Ivanova L. A.
Published: September 2019

The purpose of this work was to determine the features of the state of newborns of underage mothers. The children of minor pregnant women were examined (n=483), who were observed and gave birth to the Maternity Hospital No. 10 in St. Petersburg in 2004–2014. [1 group – 13–15 years old (n=49); 2 group – 16–17 years old (n=434)]. The comparison group consisted of 110 children of women of medium reproductive age. Significant differences in the anthropometric characteristics of newborns between groups were not found. It was shown that in children of minors of both age groups the hypotrophy of the newborn was significantly more frequently observed, as well as inflammatory diseases specific to the perinatal period (neonatal infection of the skin, conjunctivitis). Minors 13–15 years old were significantly more likely than 16–17 year olds and women of medium reproductive age to have asphyxia during labor and cephalhematoma.
Psychological features of mothers who have given birth to premature infants
Authors: Korotaeva N. V. , Ippolitova L. I. , Nastausheva T. L. , Ivanova O. A. , Kogutnitskaya M. I. , Pershina E. S.
Published: September 2019

Psychological features of mothers who have given birth to premature babies present one of the most complex and insufficiently explored areas of modern perinatal psychology. The progressive increase of the children born before the term as well as the insufficient development of psychological care programs for mothers at the women's consultation and nursing departments of newborns dictate the urgency and necessity of this problem. Using psychological techniques, the authors comprehensively assessed the personality characteristics, motives for the pregnancy preservation, personal and situational anxiety of mothers of premature babies at Perinatal Center №.1. The assessment revealed that the mothers with premature low-birth-weight babies experienced a sharp increase in situational anxiety compared to personal anxiety, while the mothers of full-term babies with a normal weight tended to decrease the level ofsituational anxiety. In addition, the mothers of premature babiessufferfrom expressed and severe depression more often than the mothers of full-term babies(p<0.05).
Perinatal cardiology: the present and the future. Part II: cardiac arrhythmias and conduction
Authors: Bockerija E. L.
Published: September 2019

The article discusses the current state of the medical care for fetuses, newborns and children with cardiac rhythm and conduction disturbances. The authors discuss the features of prenatal diagnostics of arrhythmias and management of pregnancy and childbirth of women with this pathology of the fetus. They analyze the diagnostics and treatment issues of arrhythmias in children. The article substantiates the introduction of the perinatal cardiology concept and formulates the main issues of this stage of development.
Hypoxic syndrome in hereditary diseases of connective tissue
Authors: Yurieva E. A. , Vozdvizhenskaya E. S. , Kushnareva M. V. , Semyachkina A. N. , Kharabadze M. N. , Sukhorukov V. S.
Published: September 2019

Objective. To analyze the influence of clinical and biochemical markers on the diagnostic algorithm for hypoxic syndrome in children with genetic diseases of connective tissue.

Characteristics of children and methods. There were examined 60 children were examined: 50 children with Ehlers–Danlossyndrome and 10 children with Marfan syndrome.

Results. Constant fatigue, fast fatigue, low tolerance to physical exercises, pale skin, muscle hypotonia and headache are the most frequent symptoms of a hypoxic state in children with connective tissue dysfunction. At the biochemical level, hypoxic syndrome was characterized by signs of oxidative stress. The authors noted an decrease in pO2 , an increase in pCO2 in the circulating blood, an increase in the activity of anaerobic glycolysis with accumulation of lactate and pyruvate, a decrease in the synthesis of macroergs (ATP, ADP, AMP) and the activity of the mitochondrial respiratory enzymes, the emersion of mitochondrial insufficiency in the form of ripped red fibers (RRF) in myocytes , conglomerates of lipids, calcium, glycogen. There was an increased content of peroxidation products in the blood, urine and saliva.

Conclusion. Periodic use of antihypoxants, drugs with detoxifying and immunomodulatory effect is justified for the treatment of children.
Analysis of etiopathogenetic and clinical features for chronic recurrent aphthouse stomatitis in children with rheumatic diseases
Authors: Skakodub A. A. , Geppe N. A. , Admakin O. I. , Mamedov A. A. , Shpitonkova O. V.
Published: September 2019

The aim of the study was to increase the level of diagnosis and treatment of chronic recurrent aphthous stomatitis in children with rheumatic diseases. We carried out a dental examination and treatment of 316 children with rheumatic diseases, 67 of them had chronic recurrent aphthous stomatitis. In the course of the study the authors determined and analyzed the etiological, pathogenetic and clinical features of the course of chronic recurrent aphthous stomatitis in children with rheumatic diseases. The study describes the examples of aphthousstomatitis of varying severity. Chronic recurrent aphthousstomatitisis an integralsymptom of a somatic disease, itstreatment requires the interaction of many specialists: dentist, pediatrician, rheumatologist, gastroenterologist, otolaryngologist, etc.
Diabetes and family hypercholesterolemia in a child: is it real?
Authors: Galimova L. F. , Sadykova D. I. , Leontyeva I. V. , Slastnikova E. S. , Shaidullina M. R. , Krinickaya N. V. , Shakirova A. R. , Pecheritsa O. G.
Published: September 2019

Diabetes mellitus type 1 is one of the most common chronic diseases among children. It is a pathology of carbohydrate, fat and protein metabolism caused by insulin deficiency in the target tissue. Changes in the lipid profile can be both secondary and primary. The article describes a clinical case of a combination of diabetes mellitus type 1 and family hypercholesterolemia in a child. It presents the clinical and laboratory results of the examination of the child and his parents. Familial hypercholesterolemia is confirmed by mutation of the low density lipoprotein receptor gene (LDLR) in the heterozygous state. In addition, the proband has a polymorphism of the SLCO1B1 gene, which should be considered when prescribing therapy. The demonstrated clinical case shows that familial hypercholesterolemia can be an independent disease, aggravating the course of diabetes mellitus and requiring correction of the therapy.
Analysis of the perinatal risk causes and the structure of pathology in premature children in Chelyabinsk, born with extremely low and very low body weight
Authors: Uzunova A. N. , Onishcenko N. A.
Published: September 2019

The purpose of the study is to analyze the history and structure of the pathology of premature infants with extremely low body weight and very low body weight under dynamic follow up in the monitoring department for children of the perinatal risk group. Using the method of continuous sampling we analyzed observation maps of 95 premature infants with extremely low body weight and very low body weight of gestation age from 24 to 36 weeks.

All newborns have a low Apgar score at birth and at the 5th minute, and Apgar score was lower in  children with extremely low body weight as compared with children with very low body weight. All children had congenital anomalies of the organs and systems, marked signs of immaturity, with prevailing changes in  the cardiovascular system, passability of  the renal pelvis, and congenital deformity of thigh.

Among the conditions that occurred in the perinatal period, the authors diagnosed intraventricular hemorrhage in 50.5% of patients, 89.6% of them had hemorrhage of grade II – III, all children had respiratory distress syndrome. Bronchopulmonary dysplasia was diagnosed in 60% of premature infants, its moderate and severe forms in 1/3 of the patients. All children had anemia, and 13.7% of children had a neonatal syndrome from mothers with diabetes mellitus. 1/3 of premature infants had retinopathy; its frequency did not depend on the body weight at birth. All children had a combination of pathologies. Bronchopulmonary dysplasia was combined with respiratory distress syndrome and anemia in 100% of children. The combination of bronchopulmonary dysplasia with intraventricular hemorrhage was more often recorded in patients with extremely low body weight than in patients with very low body weight.
Analytical solution of a vibrational problem for visco-elastic plate with Kelvin type boundary conditions
Authors: Sharma Ashish Kumar , Dhiman Manoj Kumar , Bensal Silky
Published: September 2019

Within this time of science and technology, tapered plates with different geometry conditions are used as a for the construction of wings and blades of aeronautical as well as engineering structures. The main aim of current work is to analyze the vibration of rectangular structure tapered plate with thermal effect variation along x and y axis. Rayleigh-Ritz method is use for judgment the solution of frequency equation. Now for several values of thermal gradient, aspect ratio and taper constant are considered to calculate structural parameters such as logarithmic decrement, time period and deflection.
Statistical analysis on the removal of malachite green dye using active carbons of Achyranthes aspera and Allamanda blanchetii plants
Authors: Ravulapalli Sujitha , Kunta Ravindhranath
Published: September 2019

Activated carbons were prepared from the stem parts of Achyranthes aspera and Allamanda blanchetii plants and were investigated as adsorbents for the removal of malachite green dye from contaminated water. Various extraction conditions such as pH, initial concentration of dye, adsorbent dosage, temperature, agitation time and presence of co-ions were optimized for the maximum possible extraction of the dye. For analyzing the combined effect of these parameters on the removal efficiency of the adsorbents, statistical optimization modelling was adopted. The adsorbents developed were characterized and the adsorption abilities were observed to be 40.0 mg/g and 53.0 mg/g for the active carbons of Achyranthes aspera and Allamanda blanchetii plants respectively. The mechanism of adsorption was studied using various isotherm models and it was found that the Freundlich model describes well the adsorption process. Thermodynamic studies revealed the endothermic and spontaneous nature of physisorption. The kinetics of adsorption were well defined by the pseudo-second-order model. Desorption and regeneration studies of the spent adsorbents indicated that the percentage of extraction has not come down below 80.0% even after five regenerations for both the adsorbents. The validity of the methods developed are tested with real dye-polluted industrial effluent samples.
Research on the water level in a bending channel using a guide wall
Authors: Zhang Jing , Zhang Qinghua , Wang Tiantian , Yang Jinmeng , Li Xuemei
Published: September 2019

In order to study the water level at the convex and concave banks after installing a guide wall in a spillway chute bend, with the original condition that the Fr at the entrance of the channel bend is larger than 1.0 (supercritical flow) when there is no the guide wall, systematic experiments with the guide wall were conducted for three radii (2.4B, 3.2B and 4B; B is the width of the channel), bottom slopes (0.01, 0.005 and 0.02), and discharges (50, 100 and150 m3 h−1). Results show that, firstly, after installing a guide wall, the Fr becomes smaller and even lower than 1.0, which means the flow status changes from supercritical to subcritical in some conditions with the help of the guide wall. Secondly, the water depth at the convex bank decreases with the increase of the relative axial radius while this presents to be adverse at the concave bank. Thirdly, for water surface differences in cross-sections, the maximum value decreases with the increase of the relative axial radius, and increases with the increase of the discharge per unit width or the bottom slope. Additionally, a novel formula for calculating the maximum water surface difference was obtained in this article.
Constitutionalism and Political Culture in Imperial Russia (Late 19th – Early 20th Century)
Authors: Taranovski T.
Published: September 2019

This article analyzes the possibility of development of liberal constitutionalism in the Russian Empire during the post-reform period in the late 19th – early 20th century within the context of European history, of which Russia was an integral component. It argues that the Russian autocracy had the potential to transform itself into a constitutional monarchy during the period that followed the Great Reforms of the 1860s (1861–1881) and, second, during the Revolution of 1905–1906 and in its aftermath. This promising evolutionary process was cut short by World War I and rejected by the Soviet period of Russian history that followed. Obstacles to constitutional government were mostly objective in character, but perhaps the most significant problem was the fragmentation and insufficient development of Russian political culture, or better said, cultures that failed to produce the consensus required for effective creation and functioning of a constitutional regime. This failure was further exacerbated by an evolutionary radicalization of revolutions in modern European history that culminated in October 1917. The author concludes that the events of the late 1980s and the Revolution of 1991 changed the character of the Russian historical landscape and provided the potential for renewed development of a pluralistic political system and a strong civil society that is its precondition.
Comic book for improving the elementary school students' mathematical problem solving skills and self-confidence
Authors: Suryatin Suryatin , Sugiman Sugiman
Published: September 2019

The study aims at generating a product in the form of comic book and also displaying the feasibility and the effectiveness of the comic book in improving the mathematical problem-solving skills and the self-confidence of the Grade IV students in the Muhammadiyah Elementary School Condongcatur Yogyakarta. The study is a Research and Development initiative (R&) with reference to 10 stages that have been developed by Borg & Gall. During the conduct of the study, the subjects were the Grade IV students of Muhammadiyah Elementary School Condongcatur Yogyakarta. The results of the study show that: (1) a comic book-based learning media that meet the criteria of feasibility based on the validation results by the material expert, the media expert, the teacher response and the students response have been generated with “Good” category; and (2) the comic book-based learning media that have been generated are effective for improving the students’ mathematical problem-solving skills and also the students’ self-confidence.
Mass media and aspiration achievement of children on primary education
Authors: Gunartati Gunartati , Mokshein Siti Eshah
Published: September 2019

Child labor is the social phenomena that not only exist in Indonesia but also in other developing countries. These children work in several sectors including in the small industrial sector. As a young generation, they also must be able to compete in the work world. Therefore, aspiration achievement is an urgent matter and must be considered by stakeholder. On the other hand, the influence of globalization is increasingly global, especially in the field of communication. Representations from this field include on the mass media. Child labor who lives in the global era is also very familiar with the mass media. The study aimed to reveal the influence of information on radio, television and family environment on aspirations achievement of child labor at the leather industry handicraft center in Wukirsari, Imogiri, Bantul. The population of this study was child workers aged 10-14 years, who worked in the leather industry handicraft centers in Wukirsari, Imogiri, Bantul and were still taking study in school, which had a total of 119 child workers. Questionnaire instruments used to obtain data of all variable. The regression analysis technique used to test the hypothesis. The results of the study showed that there was a significant positive influence on the habit to follow information from the mass media and the family environment on the aspirations of child laborers at the leather industry handicraft center in Wukirsari.
Development an honesty and discipline assessment instrument in the integrated thematic learning at elementary school
Authors: Setiawan Ari , Fajaruddin Syarief , Andini Dinar Westri
Published: September 2019

Honest and discipline as learning outcomes need to be assessed. Many teachers have difficulty developing honesty and discipline assessments. The lack of honest and discipline assessment instruments require special attention in development. The purposes of this developmental research were to find out: (1) honest and discipline instrument indicators; (2) content validity of the instrument; (3) construct validity of the instrument; (4) instrument reliability and (5) instrument application for assessment. The research method used the development of affective instruments. The research subjects were 140 students of grade IV and V on the elementary school. The instrument used a peer-assessment model with a summative rating scale. Data analysis technique used content validity with Aiken index; construct validity with Exploratory Factor Analysis (EFA); reliability with Cronbach; and application of instrument with descriptive quantitative. The results of the study were indicators of honest assessment instruments and discipline of the peer-assessment model, consisted of 4, honest: convey the true information and do the examination independently. Discipline: come to school on time and obey the rules of the school. The content validity of the developed assessment instruments based on the theory had fulfilled and included in the high category. The construct validity for the developed instrument had fulfilled; means, all items were valid. Reliability of the developed instrument had met the requirements; means, the instruments were reliable. The developed instruments can be used for assessment and proved by the use of instruments for honest and disciplined assessment of elementary school students.