bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of Perovskite (MACl)0.33FA0.99MA0.01Pb(I0.99Br0.01)3 Solar Cells via n-Octylammonium Iodide Surface Passivation
Authors: Osman M. M. , El-naggar A. M. , Alanazi A. Q. , Aldhafiri A. M. , Albassam A. A.
Published: April 2023

The influence of n-octylammonium iodide (OAI, passive layer) on the types of phases formed in a (MACl)0.33FA0.99MA0.01Pb(I0.99Br0.01)3 perovskite film was studied using X-ray diffraction. Using UV spectrophotometric techniques, it was determined how varied OAI additive layer ratios affected the linear and nonlinear optical characteristics of glass substrates/FTO/compact TiO2/mesoporous TiO2/(MACl)0.33FA0.99MA0.01Pb(I0.99Br0.01)3 films. All films’ direct optical bandgap energies were determined to be 1.54 eV. The effects of OAI addition on the films’ photoluminescence intensity and emitted colors were also investigated. For the fabricated perovskite solar cells (PSCs) without an OAI passivation layer, the corresponding power conversion efficiency (PCE), open-circuit voltage (VOC), short-circuit current density (JSC), and fill factor (FF) values were 18.8%, 1.02 V, 24.6 mAcm−2, and 75%, respectively. When the concentration of OAI reached 2 mg, the maximum obtained values of PCE, VOC, JSC, and FF were 20.2%, 1.06 V, 24.2 mAcm−2, and 79%, respectively. The decreased trap density and increased recombination resistance were responsible for the improvement in solar cell performance.
The Clinical Phenotype of Binge Eating Disorder among Postmenopausal Women: A Pilot Study
Authors: Hooper Savannah C. , Espinoza Sara E. , Marshall Victoria B. , Kilpela Lisa S.
Published: April 2023

Binge eating disorder (BED), a form of overnutrition, may impact healthy aging for postmenopausal women. In community samples, 12–26% of older women (ages 60+) engage in binge eating. In younger adults, BED is comorbid with physical and psychological morbidities. However, little is known regarding the clinical phenotype, including medical and psychiatric comorbidities, of BED in postmenopausal women. This pilot study sought to identify psychosomatic, cardiometabolic, body composition, and physical function characteristics of postmenopausal, older adult (age ≥60 years) women with BED. Participants (N = 21, ages 60–75) completed a battery of physical assessments and surveys assessing psychosomatic health. Overall, 62% of women reported BE onset during peri- or post-menopause. Rates of comorbid depression, anxiety, sleep problems, and a history of severe menopausal symptoms were high. Cardiometabolic health was poor, and 42.9% met the criteria for metabolic syndrome. Additionally, 71.4% met the BMI criteria for obesity, and 40% of this sample met the criteria for sarcopenic obesity. Almost half of the sample presented with at least one mobility limitation; 85.7% had poor endurance. Evidence suggests that BED is highly comorbid with other chronic health conditions and may complicate treatment of these conditions, warranting further investigation and increased attention from healthcare providers serving postmenopausal women.
Targeting Wnt/β-Catenin Pathway by Flavonoids: Implication for Cancer Therapeutics
Authors: Pandey Pratibha , Khan Fahad , Seifeldin Sara A. , Alshaghdali Khalid , Siddiqui Samra , Abdelwadoud Mohamed Elfatih , Vyas Manish , Saeed Mohd , Mazumder Avijit , Saeed Amir
Published: April 2023

The Wnt pathway has been recognized for its crucial role in human development and homeostasis, but its dysregulation has also been linked to several disorders, including cancer. Wnt signaling is crucial for the development and metastasis of several kinds of cancer. Moreover, members of the Wnt pathway have been proven to be effective biomarkers and promising cancer therapeutic targets. Abnormal stimulation of the Wnt signaling pathway has been linked to the initiation and advancement of cancer in both clinical research and in vitro investigations. A reduction in cancer incidence rate and an improvement in survival may result from targeting the Wnt/β-catenin pathway. As a result, blocking this pathway has been the focus of cancer research, and several candidates that can be targeted are currently being developed. Flavonoids derived from plants exhibit growth inhibitory, apoptotic, anti-angiogenic, and anti-migratory effects against various malignancies. Moreover, flavonoids influence different signaling pathways, including Wnt, to exert their anticancer effects. In this review, we comprehensively evaluate the influence of flavonoids on cancer development and metastasis by focusing on the Wnt/β-catenin signaling pathway, and we provide evidence of their impact on a number of molecular targets. Overall, this review will enhance our understanding of these natural products as Wnt pathway modulators.
A Scoping Review of the Relationship between Intermittent Fasting and the Human Gut Microbiota: Current Knowledge and Future Directions
Authors: Popa Alina Delia , Niță Otilia , Gherasim Andreea , Enache Armand Iustinian , Caba Lavinia , Mihalache Laura , Arhire Lidia Iuliana
Published: April 2023

Intermittent fasting (IF) has been promoted as an alternative to dietary caloric restriction for the treatment of obesity. IF restricts the amount of food consumed and improves the metabolic balance by synchronizing it with the circadian rhythm. Dietary changes have a rapid effect on the gut microbiota, modulating the interaction between meal timing and host circadian rhythms. Our paper aims to review the relationships between IF and human gut microbiota. In this study, the primary area of focus was the effect of IF on the diversity and composition of gut microbiota and its relationship with weight loss and metabolomic alterations, which are particularly significant for metabolic syndrome characteristics. We discussed each of these findings according to the type of IF involved, i.e., time-restricted feeding, Ramadan fasting, alternate-day fasting, and the 5:2 diet. Favorable metabolic effects regarding the reciprocity between IF and gut microbiota changes have also been highlighted. In conclusion, IF may enhance metabolic health by modifying the gut microbiota. However additional research is required to draw definitive conclusions about this outcome because of the limited number and diverse designs of existing studies.
Association between Nutrition and Health Knowledge and Multiple Chronic Diseases: A Large Cross-Sectional Study in Wuhan, China
Authors: Wang Shanshan , Wu Yating , Shi Mengdie , He Zhenyu , Hao Liping , Wu Xiaomin
Published: April 2023

Nutrition and health knowledge (NHK) is linked to people’s dietary behavior and health outcomes. However, studies on the associations between NHK and chronic diseases are limited. This study aimed to examine the association of NHK with five specific chronic diseases (diabetes/hyperglycemia, hypertension, dyslipidemia, coronary heart disease (CHD), and stroke) in central China. Individual NHK and disease status were investigated using a self-reporting questionnaire. We further added up the number of chronic diseases and used this as a secondary outcome. A total of 21,559 adults were enrolled in this cross-sectional study. NHK score was significantly inversely associated with diabetes/hyperglycemia, hypertension, CHD, and stroke (all p-trends < 0.001). Moreover, an inverse association was found between NHK and the number of chronic diseases, especially among responders with three or more chronic diseases. Stratified analyses showed that the above association was more likely to be stronger among younger, female, highly educated, and inner-city residents. However, NHK was negatively associated with dyslipidemia in less educated people and positively correlated with dyslipidemia in highly educated people. NHK showed an inverse relationship with specific chronic diseases and the number of chronic diseases. Improving NHK might be a key strategy for easing the global burden of chronic diseases.
Inadequate Energy Delivery Is Frequent among COVID-19 Patients Requiring ECMO Support and Associated with Increased ICU Mortality
Authors: Schneeweiss-Gleixner Mathias , Scheiner Bernhard , Semmler Georg , Maleczek Mathias , Laxar Daniel , Hintersteininger Marlene , Hermann Martina , Hermann Alexander , Buchtele Nina , Schaden Eva , Staudinger Thomas , Zauner Christian
Published: April 2023

Background: Patients receiving extracorporeal membrane oxygenation (ECMO) support are at high risk for malnutrition. There are currently no general nutrition guidelines for coronavirus disease 2019 (COVID-19) patients during ECMO therapy. Methods: We conducted a retrospective analysis of COVID-19 patients requiring venovenous ECMO support at a large tertiary hospital center. Nutrition goals were calculated using 25 kcal/kg body weight (BW)/day. Associations between nutrition support and outcome were evaluated using Kaplan–Meier and multivariable Cox regression analyses. Results: Overall, 102 patients accounted for a total of 2344 nutrition support days during ECMO therapy. On 40.6% of these days, nutrition goals were met. Undernutrition was found in 40.8%. Mean daily calorie delivery was 73.7% of calculated requirements, mean daily protein delivery was 0.7 g/kg BW/d. Mean energy intake of ≥70% of calculated targets was associated with significantly lower ICU mortality independently of age, disease severity at ECMO start and body mass index (adjusted hazard ratio: 0.372, p = 0.007). Conclusions: Patients with a mean energy delivery of ≥70% of calculated targets during ECMO therapy had a better ICU survival compared to patients with unmet energy goals. These results indicate that adequate nutritional support needs to be a major priority in the treatment of COVID-19 patients requiring ECMO support.
The Role of the Mediterranean Diet in Breast Cancer Survivorship: A Systematic Review and Meta-Analysis of Observational Studies and Randomised Controlled Trials
Authors: Chen Ge , Leary Sam , Niu Jizhao , Perry Rachel , Papadaki Angeliki
Published: April 2023

Female breast cancer is the most frequently diagnosed cancer. The long-term survival rates for this disease have increased; however, the unique demand for high-quality healthcare to improve breast-cancer survivorship are commonly unmet. The Mediterranean diet (MD) is associated with reduced breast-cancer risk and various health-related benefits in the general population, but its effect on breast-cancer survivors remains uncertain. The objective of this systematic review and meta-analysis was to assess current evidence from randomised controlled trials (RCTs) and observational studies (cohort, cross-sectional and case-control) regarding the effect of the MD on survival, quality of life (QoL) and health-related outcomes in female breast-cancer survivors. MEDLINE, EMBASE, Web of Science and the Cochrane library were searched for studies published before and including April 2022. Two reviewers independently screened the literature and completed the data extraction and risk-of-bias assessment. Eleven studies (fifteen reports) were included, including two RCTs, four cohort and five cross-sectional studies. The meta-analysis of the cohort studies showed strong evidence of an inverse association between high adherence to the MD and all-cause mortality (hazard ratio (HR) 0.78, 95% confidence interval (CI) 0.66–0.93, I2: 0%, Grading of Recommendations Assessment, Development and Evaluation (GRADE) = low certainty of evidence) and non-breast-cancer mortality (HR 0.67, 95% CI 0.50–0.90, I2: 0%, GRADE = very low certainty of evidence). The associations between high adherence to the MD and QoL and health-related parameters were not consistent. These findings highlight the potential of adherence to the MD to reduce the risk of mortality. Future research with better study designs, as well as more consistent measurements of QoL and MD adherence, taking into account changes in MD adherence over time and population subgroups, is needed to provide more robust evidence on the survival, QoL and health-related outcomes in BC survivors.
Citrulline, Intestinal Fatty Acid-Binding Protein and the Acute Gastrointestinal Injury Score as Predictors of Gastrointestinal Failure in Patients with Sepsis and Septic Shock
Authors: Tyszko Maciej , Lemańska-Perek Anna , Śmiechowicz Jakub , Tomaszewska Paulina , Biecek Przemyslaw , Gozdzik Waldemar , Adamik Barbara
Published: April 2023

Gastrointestinal (GI) failure can be both a cause of sepsis and a consequence of the systemic pro-inflammatory response in sepsis. Changes in biomarkers of enterocyte damage, citrulline and I-FABP (intestinal fatty acid binding protein), may indicate altered intestinal permeability and damage. The study group consisted of patients with sepsis (N = 28) and septic shock (N = 30); the control group included patients without infection (N = 10). Blood samples were collected for citrulline and I-FABP and a 4-point AGI score (acute GI injury score) was calculated to monitor GI function on days 1, 3, 5, 7, and 10. Citrulline concentrations in the study group were lower than in the control. Lower values were also noted in septic patients with shock when compared to the non-shock group throughout the study period. I-FABP was higher in the septic shock group than in the sepsis group only on days 1 and 3. Citrulline was lower in patients with GI failure (AGI III) when compared to AGI I/II, reaching significance on days 7 (p = 0.034) and 10 (p = 0.015); moreover, a higher AGI score was associated with an increased 28 day mortality (p = 0.038). The results indicate that citrulline measurements, along with the AGI assessment, have clinical potential in monitoring GI function and integrity in sepsis.
Hydroxypropyl-β-Cyclodextrin Depletes Membrane Cholesterol and Inhibits SARS-CoV-2 Entry into HEK293T-ACEhi Cells
Authors: Alboni Silvia , Secco Valentina , Papotti Bianca , Vilella Antonietta , Adorni Maria Pia , Zimetti Francesca , Schaeffer Laurent , Tascedda Fabio , Zoli Michele , Leblanc Pascal , Villa Erica
Published: April 2023

Vaccination has drastically decreased mortality due to coronavirus disease 19 (COVID-19), but not the rate of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Alternative strategies such as inhibition of virus entry by interference with angiotensin-I-converting enzyme 2 (ACE2) receptors could be warranted. Cyclodextrins (CDs) are cyclic oligosaccharides that are able to deplete cholesterol from membrane lipid rafts, causing ACE2 receptors to relocate to areas devoid of lipid rafts. To explore the possibility of reducing SARS-CoV-2 entry, we tested hydroxypropyl-β-cyclodextrin (HPβCD) in a HEK293T-ACE2hi cell line stably overexpressing human ACE2 and Spike-pseudotyped SARS-CoV-2 lentiviral particles. We showed that HPβCD is not toxic to the cells at concentrations up to 5 mM, and that this concentration had no significant effect on cell cycle parameters in any experimental condition tested. Exposure of HEK293T-ACEhi cells to concentrations of HPβCD starting from 2.5 mM to 10 mM showed a concentration-dependent reduction of approximately 50% of the membrane cholesterol content. In addition, incubation of HEK293T-ACEhi cells with HIV-S-CoV-2 pseudotyped particles in the presence of increasing concentrations of HPβCD (from 0.1 to 10 mM) displayed a concentration-dependent effect on SARS-CoV-2 entry efficiency. Significant effects were detected at concentrations at least one order of magnitude lower than the lowest concentration showing toxic effects. These data indicate that HPβCD is a candidate for use as a SARS-CoV-2 prophylactic agent.
Exploring the Association between Citrus Nutraceutical Eriocitrin and Metformin for Improving Pre-Diabetes in a Dynamic Microbiome Model
Authors: Cesar Thais , Salgaço Mateus Kawata , Mesa Victoria , Sartoratto Adilson , Sivieri Katia
Published: April 2023

Pre-diabetes is recognized as an altered metabolic state, which precedes type 2 diabetes, and it is associated with great dysfunction of the intestinal microbiota, known as dysbiosis. Natural compounds, capable of reducing blood glucose without side effects and with a beneficial effect on the microbiota, have been studied as substitutes or adjuvants to conventional hypoglycemic agents, such as metformin. In this work, the effect of the nutraceutical Eriomin®, a mixture of citrus flavonoids (eriocitrin, hesperidin, naringin, and didymin), which reduces glycemia and increases glucagon-like peptide-1 (GLP-1) in pre-diabetic patients, was tested in the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), inoculated with pre-diabetic microbiota. After treatment with Eriomin® plus metformin, a significant increase in acetate and butyrate production was observed. Furthermore, sequencing of the 16S rRNA gene of the microorganisms showed that Eriomin® plus metformin stimulated the growth of Bacteroides and Subdoligranulum genera. Bacteroides are the largest fraction of the intestinal microbiota and are potential colonizers of the colon, with some species producing acetic and propionic fatty acids. In addition, Subdoligranulum species are associated with better host glycemic metabolism. In conclusion, Eriomin® associated with metformin improved the composition and metabolism of the intestinal microbiota, suggesting a potential use in pre-diabetes therapy.
An mRNA-Based Multiple Antigenic Gene Expression System Delivered by Engineered Salmonella for Severe Fever with Thrombocytopenia Syndrome and Assessment of Its Immunogenicity and Protection Using a Human DC-SIGN-Transduced Mouse Model
Authors: Park Ji-Young , Hewawaduge Chamith , Sivasankar Chandran , Lloren Khristine Kaith S. , Oh Byungkwan , So Mi Young , Lee John Hwa
Published: April 2023

Currently, there are no commercial vaccines or therapeutics against severe fever with thrombocytopenia syndrome (SFTS) virus. This study explored an engineered Salmonella as a vaccine carrier to deliver a eukaryotic self-mRNA replicating vector, pJHL204. This vector expresses multiple SFTS virus antigenic genes for the nucleocapsid protein (NP), glycoprotein precursor (Gn/Gc), and nonstructural protein (NS) to induce host immune responses. The engineered constructs were designed and validated through 3D structure modeling. Western blot and qRT-PCR analyses of transformed HEK293T cells confirmed the delivery and expression of the vaccine antigens. Significantly, mice immunized with these constructs demonstrated a cell-mediated and humoral response as balanced Th1/Th2 immunity. The JOL2424 and JOL2425 delivering NP and Gn/Gc generated strong immunoglobulin IgG and IgM antibodies and high neutralizing titers. To further examine the immunogenicity and protection, we utilized a human DC-SIGN receptor transduced mouse model for SFTS virus infection by an adeno-associated viral vector system. Among the SFTSV antigen constructs, the construct with full-length NP and Gn/Gc and the construct with NP and selected Gn/Gc epitopes induced robust cellular and humoral immune responses. These were followed by adequate protection based on viral titer reduction and reduced histopathological lesions in the spleen and liver. In conclusion, these data indicate that recombinant attenuated Salmonella JOL2424 and JOL2425 delivering NP and Gn/Gc antigens of SFTSV are promising vaccine candidates that induce strong humoral and cellular immune responses and protection against SFTSV. Moreover, the data proved that the hDC-SIGN transduced mice as a worthy tool for immunogenicity study for SFTSV.
Accelerated Production of Biopharmaceuticals via Microwave-Assisted Freeze-Drying (MFD)
Authors: Härdter Nicole , Geidobler Raimund , Presser Ingo , Winter Gerhard
Published: April 2023

Recently, attention has been drawn to microwave-assisted freeze-drying (MFD), as it drastically reduces the typically long drying times of biopharmaceuticals in conventional freeze-drying (CFD). Nevertheless, previously described prototype machines lack important attributes such as in-chamber freezing and stoppering, not allowing for the performance of representative vial freeze-drying processes. In this study, we present a new technical MFD setup, designed with GMP processes in mind. It is based on a standard lyophilizer equipped with flat semiconductor microwave modules. The idea was to enable the retrofitting of standard freeze-dryers with a microwave option, which would reduce the hurdles of implementation. We aimed to collect process data with respect to the speed, settings, and controllability of the MFD processes. Moreover, we studied the performance of six monoclonal antibody (mAb) formulations in terms of quality after drying and stability after storage for 6 months. We found drying processes to be drastically shortened and well controllable and observed no signs of plasma discharge. The characterization of the lyophilizates revealed an elegant cake appearance and remarkably good stability in the mAb after MFD. Furthermore, overall storage stability was good, even when residual moisture was increased due to high concentrations of glass-forming excipients. A direct comparison of stability data following MFD and CFD demonstrated similar stability profiles. We conclude that the new machine design is highly advantageous, enabling the fast-drying of excipient-dominated, low-concentrated mAb formulations in compliance with modern manufacturing technology.
The Pillars for Renal Disease Treatment in Patients with Type 2 Diabetes
Authors: Kearney Jessica , Gnudi Luigi
Published: April 2023

The diabetes epidemic and the increasing number of patients with diabetic chronic vascular complications poses a significant challenge to health care providers. Diabetic kidney disease is a serious diabetes-mediated chronic vascular complication and represents a significant burden for both patients and society in general. Diabetic kidney disease not only represents the major cause of end stage renal disease but is also paralleled by an increase in cardiovascular morbidity and mortality. Any interventions to delay the development and progression of diabetic kidney disease are important to reduce the associated cardiovascular burden. In this review we will discuss five therapeutic tools for the prevention and treatment of diabetic kidney disease: drugs inhibiting the renin–angiotensin–aldosterone system, statins, the more recently recognized sodium-glucose co-transporter-2 inhibitors, glucagon-like peptide 1 agonists, and a novel non-steroidal selective mineralocorticoid receptor antagonist.
Prospects for the Use of Metal-Based Nanoparticles as Adjuvants for Local Cancer Immunotherapy
Authors: Naletova Irina , Tomasello Barbara , Attanasio Francesco , Pleshkan Victor V.
Published: April 2023

Immunotherapy is among the most effective approaches for treating cancer. One of the key aspects for successful immunotherapy is to achieve a strong and stable antitumor immune response. Modern immune checkpoint therapy demonstrates that cancer can be defeated. However, it also points out the weaknesses of immunotherapy, as not all tumors respond to therapy and the co-administration of different immunomodulators may be severely limited due to their systemic toxicity. Nevertheless, there is an established way through which to increase the immunogenicity of immunotherapy—by the use of adjuvants. These enhance the immune response without inducing such severe adverse effects. One of the most well-known and studied adjuvant strategies to improve immunotherapy efficacy is the use of metal-based compounds, in more modern implementation—metal-based nanoparticles (MNPs), which are exogenous agents that act as danger signals. Adding innate immune activation to the main action of an immunomodulator makes it capable of eliciting a robust anti-cancer immune response. The use of an adjuvant has the peculiarity of a local administration of the drug, which positively affects its safety. In this review, we will consider the use of MNPs as low-toxicity adjuvants for cancer immunotherapy, which could provide an abscopal effect when administered locally.
The Prevalence and Impact of Evidence-Based Medications on Cardiovascular and Cerebrovascular Outcomes in Patients with Acute Coronary Syndrome Post-Revascularization in Oman
Authors: Al-Hadithy Dalia Ahmed , Al-Maqbali Juhaina Salim , Al-Riyami Adil , Al Za’abi Mohammed , Al-Zakwani Ibrahim
Published: April 2023

Objectives: International cardiovascular guidelines recommend prescribing a combination of five evidence-based medications (EBM) for acute coronary syndrome (ACS) patients post-revascularization. This study aims to assess the prevalence and impact of prescribing the full (five medications) versus partial (four medications or fewer) EBM combination on major adverse cardiovascular and cerebrovascular events (MACCE) in patients with ACS post-revascularization. Methods: Data from patients with ACS who had revascularization between January 2016 and September 2021 were collected retrospectively. Patients were then followed up until March 2022 for MACCE. Results: The full EBM combination was prescribed to 70% of the patients. However, after taking into account the presence of contraindications and clinical factors, the actual adherence to the guidelines was 95%. Patients who received the full EBM combination were younger (58 versus 62 years; p = 0.0 and 3) and had lower rates of chronic kidney disease (11% versus 41%; p < 0.001) and heart failure (9% versus 20%; p = 0.012) when compared to patients who received the partial EBM. Compared to the partial EBM group, the full EBM group was associated with lower MACCE rates (54% versus 37%, p = 0.012). After employing the propensity score technique utilizing the 1:1 nearest neighbor matching method without replacement, the univariate findings were further re-affirmed with those on full EBMs (compared to those on partial EBMs) associated with a significant reduction in the MACCE rate (average treatment effect of −25%; 95% confidence interval: −10–−40%; p = 0.001). Conclusions: The full EBM utilization was significantly high in our setting and in line with international guidelines. The full EBM combination was predominantly prescribed in younger and less comorbid patients and was associated with lower MACCE rates. The findings were further reaffirmed by the propensity score matching method.
Response of Superoxide Dismutase (SOD) to Homogeneous and Heterogeneous Food Sources in Bumblebees (Bombus terrestris) and Honeybees (Apis mellifera)
Authors: Ludewig María José , Götz Klaus-Peter , Romero-Oliva Claudia S. , Landaverde Patricia , Chmielewski Frank-M.
Published: April 2023

The conception of “floral strips” is a strategy to provide more and different food sources for pollinators. The impact of “homogeneous” Phacelia tanacetifolia (“Phacelia”) and “heterogeneous” (flower mix) food sources on the enzyme activity of bumblebees (Bombus terrestris) and honeybees (Apis mellifera) under urban conditions has not been reported. Organisms responding to challenging environmental conditions are known to exhibit increases in oxidative stress parameters which in turn affect both physiological and metabolic parameters. A field study was conducted in Berlin-Dahlem, Germany, using the response of the “marker” enzyme superoxide dismutase (SOD) on food sources for assessment. SOD data is also shown from the wild bee Megachile rotundata (Fabricius 1787), obtained from three different locations in the federal state Brandenburg, Germany. The results demonstrate that the enzyme activity of SOD significantly increased in bumblebees visiting the flower mix compared to the Phacelia. The experimental approach had individual effects at the level of the species, bumblebees and honeybees, respectively. The activity of the biomarker SOD could be successfully used to assess the effects of the compositions of homogeneous and heterogeneous flower fields.
Role of the Dietary Phytochemical Curcumin in Targeting Cancer Cell Signalling Pathways
Authors: Mishra Abhay Prakash , Swetanshu  , Singh Pratichi , Yadav Shikha , Nigam Manisha , Seidel Veronique , Rodrigues Celia Fortuna
Published: April 2023

The diarylheptanoid curcumin [(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione] is one of the phenolic pigments responsible for the yellow colour of turmeric (Curcuma longa L.). This phytochemical has gained much attention in recent years due to its therapeutic potential in cancer. A range of drug delivery approaches have been developed to optimise the pharmacokinetic profile of curcumin and ensure that it reaches its target sites. Curcumin exhibits numerous biological effects, including anti-inflammatory, cardioprotective, antidiabetic, and anti-aging activities. It has also been extensively studied for its role as a cancer chemopreventive and anticancer agent. This review focusses on the role of curcumin in targeting the cell signalling pathways involved in cancer, particularly via modulation of growth factors, transcription factors, kinases and other enzymes, pro-inflammatory cytokines, and pro-apoptotic and anti-apoptotic proteins. It is hoped that this study will help future work on the potential of curcumin to fight cancer.
Vernonia britteniana Root Phytochemical Studies, In Vitro Cercaricidal Activity on the Larval Stage of Schistosoma mansoni and Antioxidant Activities
Authors: Valente Maria dos Anjos , Ferreira Pedro , Lima Katelene , Moreira da Silva Isabel B. , Nobre Paula , Neto Isabel , Pires Mavilde , Braz Berta São , Serrano Rita , Belo Silvana , Silva Olga
Published: April 2023

Vernonia britteniana Hiern. (Asteraceae) is a medicinal plant used in traditional Angolan medicine against schistosomiasis. Our study aimed to investigate the phytochemical composition and the cercaricidal and antioxidant activities in vitro of a traditional herbal preparation (Water-Vbr) and a 70% hydroethanolic extract (EtOH70%-Vbr) prepared with this medicinal plant. The activity of the extracts against Schistosoma mansoni cercariae was assessed at different extract concentrations (500, 438, and 125 µg/mL) and at different time intervals, and the phytochemical profiles were obtained by LC-UV-ESI/MS-MS. In addition, the major chemical classes of the identified metabolites were quantified by colorimetry, and the antioxidant potential was assessed using the DPPH and FRAP methods. After 30 min, 100% cercarial mortality was observed at a concentration of 500 μg/mL after exposure, and after 120 min, an LC50 of 438 μg/mL was observed for both extracts. Phenolic acid derivatives (chlorogenic acid, caffeic acid; 3,4-di-O-caffeoylquinic acid; 3,5-di-O-caffeoylquinic acid; and 4,5-di-O-caffeoylquinic acid) and triterpenoids (stigmastane-type steroidal saponins; vernoamyoside D and vernonioside D1; vernoamyoside B; and vernoniamyoside A and C) were identified as the main secondary metabolites. The Water-Vbr extract showed the highest antioxidant activity—DPPH: IC50 = 1.769 ± 0.049 µg/mL; FRAP: mean = 320.80 ± 5.1325 µgAAE/g.
Thermal Conductivities of Uniform and Random Sulfur Crosslinking in Polybutadiene by Molecular Dynamic Simulation
Authors: Alamfard Tannaz , Lorenz Tommy , Breitkopf Cornelia
Published: April 2023

Thermal conductivities of polybutadiene crosslinked with sulfur as a function of the heat flux autocorrelation function by using an equilibrium molecular dynamic (EMD) simulation were investigated. The Green–Kubo method was used to calculate thermal conductivities. All simulations were performed by applying the LAMMPS software (version 3 Mar 2020) package. The united-atom force field (OPLS-UA) from the Moltemplate software (version 2.20.3) was applied in the simulations. The influence of uniform and random distributions of sulfur in polybutadiene on the final value of thermal conductivities was studied by polymeric model structures with similar and variable degrees of crosslinking. The results showed that for identical degrees of crosslinking, the distribution of crosslinkers in the polymeric model structures significantly influenced the final value of thermal conductivity. Moreover, the influence of the crosslinking degree on the final value of thermal conductivity was studied by considering polymeric model structures with different degrees of crosslinking. The results demonstrate that by having a random distribution of sulfur, the thermal conductivity will be enhanced. However, by increasing the degree of crosslinking to the higher percentage in random crosslinked model structures, the value of thermal conductivity drops significantly due to possible higher crystallization of the model structures, which decrease the degree of freedom for phonon contributions.
Microstructural Dynamics of Polymer Melts during Stretching: Radial Size Distribution
Authors: Hsieh Ming-Chang , Tsao Yu-Hao , Sheng Yu-Jane , Tsao Heng-Kwong
Published: April 2023

The transient elongational viscosity ηe(t) of the polymer melt is known to exhibit strain hardening, which depends on the strain rate ε˙. This phenomenon was elucidated by the difference of chain stretching in the entanglement network between extension and shear. However, to date, the microscopic evolution of polymer melt has not been fully statistically analyzed. In this work, the radial size distributions P(Rg,t) of linear polymers are explored by dissipative particle dynamics during the stretching processes. In uniaxial extensional flow, it is observed that the mean radius of gyration R¯g(t) and standard deviation σ(t) remain unchanged until the onset of strain hardening, corresponding to linear viscoelasticity. Both R¯g and σ rise rapidly in the non-linear regime, and bimodal size distribution can emerge. Moreover, the onset of strain hardening is found to be insensitive to the Hencky strain (ε˙Ht) and chain length (N).
Reinforced Polymer Composites III
Authors: Tcherdyntsev Victor V.
Published: April 2023

The development of modern technology requires the development of new materials with improved operational and technological properties [...]
Enhancing the Toughness of Free-Standing Polyimide Films for Advanced Electronics Applications: A Study on the Impact of Film-Forming Processes
Authors: Zhao Ruoqing , Wu Hao , Dong Xuan , Xu Manzhang , Wang Zhenhua , Wang Xuewen
Published: April 2023

High-quality and free-standing polyimide (PI) film with desirable mechanical properties and uniformity is in high demand due to its widespread applications in highly precise flexible and chip-integrated sensors. In this study, a free-standing PI film with high toughness was successfully prepared using a diamine monomer with ether linkages. The prepared PI films exhibited significantly superior mechanical properties compared to PI films of the same molecular structure, which can be attributed to the systematic exploration of the film-forming process. The exploration of the film-forming process includes the curing procedures, film-forming substrates, and annealing treatments. Additionally, the thickness uniformity and surface homogeneity of free-standing films were crucial for toughness. Increasing the crystallinity of the PI films by eliminating residual stress also contributed to their high strength. The results demonstrate that by adjusting the above-mentioned factors, the prepared PI films possess excellent mechanical properties, with tensile strength and elongation at break of 194.71 MPa and 130.13%, respectively.
The Methods and Characteristics of the Electrochemical Oxidation Degradation of HMX
Authors: Qian Yishi , Jing Xiaosheng , Yan Wei , Xi Peng
Published: April 2023

Octagon (HMX) is a typical organic pollutant of explosives in the surrounding environments of military factories, and it is widely regarded as a carcinogen which may enter the human body through wastewater and atmospheric exposure, resulting in potential health risks. Therefore, this paper studies the degradation of HMX by electrochemical oxidation. In this study, an electrochemical system was built using a copper plate as the cathode and a Ti/PbO2 electrode as the anode. The effects of various process variables, such as the initial pH value, the current density, and the distance between the electrodes, were investigated in relation to HMX degradation. Following this, performance optimization and intermediate analysis were carried out, along with an estimation of the energy consumption of HMX deterioration in various operating situations. The experimental results in this paper show that when the electrolyte concentration is 0.25 mol/L, the current density is 70 mA/cm2, the electrode spacing is 1.0 cm, and the initial pH is 5.0. Electrochemical oxidation has a better treatment efficiency for pollutants, and the removal rate reaches 81.2%. The findings of kinetic research reveal that the electrochemical oxidation degradation process of HMX follows quasi-first-order kinetics, and protein stress and Deoxyribo Nucleic Acid (DNA) loss stress are significantly different from other stress types throughout the whole degradation process. HMX degradation solution causes damage to protein transcription or expression. However, some genes of oxidative stress are continuously up-regulated, because H2O2 and OH produced by electrochemical oxidation cause a strong response to oxidative stress in cells. The research findings in this report offer crucial guidance and suggestions for the industrialization of HMX wastewater treatment.
A Stoic Reading of Internal Obedience in Romans 1:18–2:29
Authors: Wilson Laurie A. , Blois Isaac D.
Published: April 2023

Romans 1:18-2:29 connects with Stoic philosophy in a way that would be unmistakable to a Gentile audience. While acknowledging the Hellenistic tone of the passage, this paper focuses on the Stoic elements of natural law that were broadly recognized in Rome. Particularly, Cicero’s speeches, rhetorical handbooks, and philosophical treatises provide a comprehensive account of the connections between Hellenistic philosophy and Roman law and declamation. Although no direct evidence exists to show that Paul had read Cicero, these texts reveal the culture of the Roman Christians to whom Paul was writing. Key concepts of natural law appear in Romans that contextualize Paul’s message on internal obedience in 2:27-29, although he reworks them. Paul emphasizes spirit ‘πνεῦμα’ as the generating force of obedience. Two interpretations of πνεῦμα echo Stoic perspectives as the intent opposed to the letter of the law and as the inward motivation of the person obeying the law. The third interpretation as a foreshadowing of the Holy Spirit would be new for Paul’s Roman audience. This paper demonstrates that by incorporating Stoic elements on natural law, Paul presents the central significance of internal obedience in a way that would be understandable to his Christ-believing auditors and readers in Rome.
Christianity and Its Impact on the Lives of Kallars in Tamil Nadu Who Embraced the Faith, in Comparison to Those Who Did Not: Special Reference to Kallar Tamil Lutheran Christians in Tamil Nadu
Authors: Murthy Jayabalan
Published: April 2023

The German and Swedish Lutheran Mission was a major and pioneering Protestant mission society that started its mission work in Tamil Nadu. The Halle Danish, Leipzig mission, and Church of Sweden mission societies had a larger mission field in Tamil Nadu. Tamil Evangelical Lutheran Christians are intimately associated with the German Lutheran Mission and Swedish Mission. The first German Lutheran missionaries, Bartholomäus Ziegenbalg and Heinrich Plütschau, came to India in 1706. From then on, many Lutheran missionaries came to Tamil Nadu. Afterwards Tamil Nadu became a thriving Christian center for decades, with a strong Christian congregation, church, and several institutions. The majority of these Christians are descendants of Dalits (former untouchable Paraiyars) and Kallars who embraced Christianity. From a life of near slavery, poverty, illiteracy, oppression, and indignity, conversion to Christianity transformed the lives of these people. Tamil Evangelical Lutheran Dalits and Kallars found liberation and have made significant progress because of the Christian missionaries of the Church of the German and Swedish Mission. Both the German and Swedish Mission offered the Gospel of a new religion to not only the subaltern people but also the possibility of secular salvation. The history of Lutherans needs to be understood as a part of Christian subaltern history (Analysing the Indian mission history from the native perspective). My paper will mainly focus on Tamil Lutheran Dalit and Kallar Christians. In this paper, I propose to elucidate the role of German and Swedish Lutheran missionaries in the social, economic, educational, and spiritual life of Tamil Lutheran Dalits and Kallars. Due to the page limit, I am going to mainly focus on Swedish Mission and Kallar Lutheran Christians.
Automatic Detection of Daytime Sea Fog Based on Supervised Classification Techniques for FY-3D Satellite
Authors: Wang Yu , Qiu Zhongfeng , Zhao Dongzhi , Ali Md. Arfan , Hu Chenyue , Zhang Yuanzhi , Liao Kuo
Published: April 2023

Polar-orbiting satellites have been widely used for detecting sea fog because of their wide coverage and high spatial and spectral resolution. FengYun-3D (FY-3D) is a Chinese satellite that provides global sea fog observation. From January 2021 to October 2022, the backscatter and virtual file manager products from CALIPSO (Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation) were used to label samples of different atmospheric conditions in FY-3D images, including clear sky, sea fog, low stratus, fog below low stratus, mid–high-level clouds, and fog below the mid–high-level clouds. A 13-dimensional feature matrix was constructed after extracting and analyzing the spectral and texture features of these samples. In order to detect daytime sea fog using a 13-dimensional feature matrix and CALIPSO sample labels, four supervised classification models were developed, including Decision Tree (DT), Support Vector Machine (SVM), K-Nearest Neighbor (KNN), and Neural Network. The accuracy of each model was evaluated and compared using a 10-fold cross-validation procedure. The study found that the SVM, KNN, and Neural Network performed equally well in identifying low stratus, with 85% to 86% probability of detection (POD). As well as identifying the basic components of sea fog, the SVM model demonstrated the highest POD (93.8%), while the KNN had the lowest POD (92.4%). The study concludes that the SVM, KNN, and Neural Network can effectively distinguish sea fog from low stratus. The models, however, were less effective at detecting sub-cloud fog, with only 11.6% POD for fog below low stratus, and 57.4% POD for fog below mid–high-level clouds. In light of this, future research should focus on improving sub-cloud fog detection by considering cloud layers.
Sea Surface Moving Target Detection Using a Modified Keystone Transform on Wideband Radar Data
Authors: Chang Jiayun , Fu Xiongjun , Zhao Congxia , Feng Cheng
Published: April 2023

The echoes collected by wideband radar systems provide abundant information on target scatterers, which is beneficial to target detection, classification, and recognition. However, as the radar range resolution increases, range cell migration (RCM) during the coherent integration (CI) period happens much easier, which may cause a degradation of target detection probability. In addition, due to the target’s orientation and structure relative to the radar, the distribution characteristics of the target scatterers in high-resolution range profiles (HRRPs) and the detection window length may vary from pulse to pulse, which may reduce the performance of traditional energy integration (EI) detectors. To solve those problems, moving range-spread target (RST) detection combining the modified keystone transform (MKT) and improved EI (IEI) is proposed in this paper. Firstly, based on waveform entropy minimization, MKT using hunter–prey optimization (HPO) is introduced to reduce the CI gain loss. The target Doppler ambiguity factor is estimated using such an effective optimization technique. Then, the IEI detector optimized by the adaptive threshold and detection window is utilized to achieve target detection, which minimizes the sensitivity of the traditional EI detector to the detection window length. The proposed method significantly improves the performance of moving RSTs in sea clutter without prior knowledge of the target Doppler ambiguity factor. Experiments are conducted by comparing the proposed method with other competing methods on both simulation data and real sea clutter data. The results demonstrate that the proposed method can obtain the CI more efficiently and has a higher detection probability.
Shifted Global Vegetation Phenology in Response to Climate Changes and Its Feedback on Vegetation Carbon Uptake
Authors: Fang Husheng , Sha Moquan , Xie Yichun , Lin Wenjuan , Qiu Dai , Tu Jiangguang , Tan Xicheng , Li Xiaolei , Sha Zongyao
Published: April 2023

Green vegetation plays a vital role in energy flows and matter cycles in terrestrial ecosystems, and vegetation phenology may not only be influenced by, but also impose active feedback on, climate changes. The phenological events of vegetation such as the start of season (SOS), end of season (EOS), and length of season (LOS) can respond to climate changes and affect gross primary productivity (GPP). Here, we coupled satellite remote sensing imagery with FLUXNET observations to systematically map the shift of SOS, EOS, and LOS in global vegetated area, and explored their response to climate fluctuations and feedback on GPP during the last two decades. The results indicated that 11.5% of the global vegetated area showed a significantly advanced trend in SOS, and that only 5.2% of the area presented significantly delayed EOS during the past two decades, resulting in significantly prolonged LOS in 12.6% of the vegetated area. The climate factors, including seasonal temperature and precipitation, attributed to the shifts in vegetation phenology, but with high spatial and temporal difference. LOS was positively and significantly correlated with GPP in 20.2% of the total area, highlighting that longer LOS is likely to promote vegetation productivity. The feedback on GPP from the shifted vegetation phenology may serve as an adaptation mechanism for terrestrial ecosystems to mitigate global warming through improved carbon uptake from the atmosphere.
Atmospheric CW S-Lidars with Si/InGaAs Arrays: Potentialities in Real Environment
Authors: Agishev Ravil , Wang Zhenzhu , Liu Dong
Published: April 2023

The article proposes a methodology for analyzing the performance of S-lidars (S comes from Scheimpflug) as a new class of environmental remote sensors operating under conditions of wide variability of optical weather and sky background brightness. The novelty of the problem statement, the methods used and the results obtained are determined by their application to laser sensing systems with unconventional design principles and the consequent need to revise the traditional ways of assessing their potential capabilities. The research method is based on a dimensionless-parametric approach, which allows comparing phenomena and systems of different scales and combining complementary characteristics and parameters. Effects of the dimensionless optical weather factor on lidar potential are shown being investigated under various environmental conditions, from the clear atmosphere through haze and mist to fog when probing in Vis/SWIR spectral bands and using Si/InGaAs detector arrays. It is shown exactly how and to what extent the significant differences in their spectral sensitivity and internal noise parameters are susceptible to the wide spectral and energy variability of the sky background brightness observed at very different angles to the Sun. A detailed analysis of the two most important influencing factors within the system, “S-Lidar instrument + Optical weather + External background source”, taking into account their wide variability, allowed us to describe their joint nonlinear influence and, thus, to anticipate the imposed limitations. The proposed dimensionless-parametric concept for predicting the potential capabilities of S-lidars with Si/InGaAs arrays is aimed at expanding applications of this rapidly developing class of remote sensors in a wide variety of environments.