bluuebunny/crossref_metadata_2025 huggingface dataset:
MODEL PENGELOLAAN DANA DESA MELALUI PRINSIP AKUNTABILITAS PUBLIK DAN TRANSPARANSI DI KABUPATEN BANDUNG
Authors: Lilis Saidah Napisah  , Cecep Taufiqurachman
Published: December 2020

Penelitian ini bertujuan untuk mengetahui pengaruh akuntabilitas publik dan transparansi terhadap pengelolaan dana desa. Akuntabilitas publik dan transparansi merupakan independen serta pengelolaan dana desa merupakan variable dependen. Metode yang digunakan dalam penelitian ini deskriptif dan verifikatif. Data yang digunakan adalah data primer, data diperoleh dari penyebaran kuesioner pada perangkat desa dan masyarakat desa. Sampel penelitian ini menggunakan sampel jenuh. Metode analisis yang digunakan adalah analisis regresi linear berganda dengan program yang digunakan menggunakan SPSS 23.00. Hasil penelitian menunjukan bahwa secara parsial akuntabilitas publik berpengaruh signifikan terhadap pengelolaan dana desa, dan transparansi berpengaruh signifikan terhadap pengelolaan dana desa. Secara simultan akuntabilitas publik dan transparansi berpengaruh secara signifikan positif terhadap pengelolaan keuangan sebesar 38,3% sedangkan sisanya 61,7% dipengaruhi variable lain yang tidak diteliti dalam penelitian ini.
Long- and Short-term Variability of Galactic Cosmic-Ray Radial Intensity Gradients between 1 and 9.5 au: Observations by Cassini, BESS, BESS-Polar, PAMELA, and AMS-02
Authors: Roussos Elias , Dialynas Konstantinos , Krupp Norbert , Kollmann Peter , Paranicas Christopher , Roelof Edmond C. , Yuan Chongjing , Mitchell Donald G. , Krimigis Stamatios M.
Published: December 2020

Spatial gradients of galactic cosmic-ray (GCR) fluxes are important for studying charged particle transport in the heliosphere. Little is known so far about how these gradients evolve with time. Here we present how the radial gradient (G

r
) evolves between 2006 January and 2017 September using Cassini measurements of >300 MeV protons, which we combine with proton spectra obtained by advanced observatories at Earth (BESS, BESS-Polar, PAMELA, and AMS-02). All gradient calculations were performed for a nearly constant heliocentric distance of Cassini from Earth’s orbit and near the ecliptic, thus revealing only how G

r
changes with time. The variability patterns of G

r
are well established as they rely on a single data set for ∼9.5 au and accurately cross-calibrated GCR spectra for Earth at 1 au. We show that over solar-cycle timescales, G

r
is regulated by both the polarity of the solar magnetic field and the solar-cycle phase. During the negative-polarity phase (A < 0, 2006–2014), gradients are stronger and more stable with an average of G

r
 = 3.5 ± 0.3%/au and with evidence of a minimum around the 2009 solar minimum. The gradient peaks at ∼4%/au around the solar maximum and subsequently experiences a gradual drop to ∼2%/au in the A > 0 phase (2014–2017). Regular G

r
enhancements over yearly or biennial timescales are also observed, in phase with quasi-biennial oscillations in GCR intensity. While all aforementioned results are based on Cassini measurements that are integral in energy, they are most representative for GCR protons in the low gigaelectronvolt range.
Insulin Resistance and Contrainsular Response in Type 2 Diabetes Mellitus Patients with Acute Coronary Syndrome
Authors: Sheryazdanova Dinara , Laryushina Yelena M. , Muravlyova Larissa , Turgunova Lyudmila  G. , Alina Assel  R. , Vassilyeva Natalya V. , Turmukhambetova Anar A.
Published: December 2020

BACKGROUND: The number of patients with diabetes mellitus (DM) is progressively increasing all over the world. Over the past three decades, the global burden of diabetes has increased from 30 million in 1985 to 382 million in 2015, and current trends indicate that the prevalence of diabetes grows progressively. The phenomenon of insulin resistance established in the majority of type 2 DM (T2DM) patients. T2DM is associated with β-cell deficiency, α-cell resistance to insulin, and reduced effects of incretin. However, the role of insulin and glucagon in the process of cardiovascular complications in diabetic patients is a matter of debate.
AIM: Our study aims to estimate insulin resistance and the contrainsular response in patients with T2DM and acute coronary syndrome (ACS).
METHODS: The 104 T2DM patients aged 18–70 years participated in the observational study carried out in the Karaganda regional cardiosurgery hospital and ambulatory. The first group included 37 patients hospitalized for ACS in the first 24 h of admission. The second group included 67 patients without ACS. Determination of insulin resistance and contrainsular response was provided using a multiplex immunological assay with XMap technology on Bioplex 3D.
RESULTS: During the research, we have discovered a decreased level of glucagon and increased homeostasis model assessment of insulin resistance (HOMA-IR) in patients with T2DM diabetes and ACS. Evaluation of traditional correlation interactions of HOMA-IR and indicators of carbohydrate metabolism showed a positive correlation with fasting plasma glucose in both study groups (Group 1: R = 0.47, p = 0.003; Group 2: R = 0.41, p = 0.024). Glucagon-like peptide (GLP)-1 has a weak positive correlation with HOMA-IR only in the first group (R = 0.32, p = 0.006). Increased insulin resistance was associated with high GLP-1 levels and low glucagon. The logistic regression model established that an increased HOMA-IR index rises the chance of ACS by 10.6% (OR = 1.106 [95% CI 1.105–1.206], p = 0,021). The logistic regression model, reflecting the relation between glucagon and ACS, shows that increased glucagon reduces the ACS odds (OR = 0.989 [95% CI 0.979–0.999], p = 0.026). The adjusted regression model showed no significant influence of early presented factors on the probability of ACS.
CONCLUSION: There is a trend toward elevated HOMA-IR insulin resistance index and decreased level of glucagon in diabetic patients with ACS.
Unstable Education System Inducing Mental Stress in COVID-19 Lockdown
Authors: Singh Gurjant
Published: December 2020

Coronavirus disease or COVID-19 caused by SARS-CoV-2 has triggered a respiratory tract infection claiming more than 3 lakh lives worldwide with 4.5 million cases and still counting. This is the worst hit of the 21st century which has made it to be announced as a pandemic by WHO on March 11, 2020. It is not possible at the time to comment if the virus has appeared all of a sudden or its gradual emerging in a short or long time with information passed lately. However, the virus has adjourned the life of humans in almost every aspect with most of the countries, including India announcing nationwide lockdowns. The news of progress over medicine or vaccine over days is no doubt giving hope to the stressed-out humanity which is being striked out again by some higher health officials warning that the coronavirus may never go away. Such news is always creating panic and claiming mental peace, building more stress in individuals. Amidst all these crisis, there is a field which took everyone’s attention, that is the education of the students. However, Indians are always known to emerge out stronger in challenges, so did they, when it was the matter of future of the students. Although Indian education system is not much familiar to such measures, it was the call and need of the situation to clasp to a different mode of education effectively and efficiently. Even with this much dedication, there seem to be some points on which the education system is breaking down gradually without the awareness of many. This article has focused on a few of such challenges imposed by the COVID-19 lockdown on the education system in India.
The Role of Mesenchymal Stem Cells in Decreasing Interleukin-12 Human Systemic Lupus Erythematosus
Authors: Munir Delfitri , Lubis Rodiah Rahmawaty , Darlan Dewi Masyithah , Putra Agung , Allif Iffan
Published: December 2020

BACKGROUND: Systemic lupus erythematosus (SLE) disease is characterized by a loss of self-tolerance leading to a local tissue inflammation up to a massive systemic organ-spesific inflammation. Mesenchymal stem cells (MSCs) present immunomodulatory properties to control the over-activating immune responses in SLE through several mechanisms. However, the capability of MSCs to decrease interleukin (IL)-12 production in in vitro remains unclear.
AIM: The aim of this study was to investigate the role of MSCs in decreasing the level of IL-12 derived from peripheral blood mononuclear cells (PBMCs) of SLE patients.
METHODS: This study used a post-test control group design using a coculture of PBMCs from SLE and healthy patients with MSCs as the subjects. This study included five groups: sham (Sh), control (C), and treatment groups (T) treated by a co-culture MSCs with PBMCs at ratio dose of 1:1 (T1), 1:25 (T2), and 1:50 (T3), respectively, for 72 hours of incubation. The IL-12 levels was analysed by cytometric bead array (CBA) of flow cytometry.
RESULTS: This study showed a significant decrease of IL-12 levels (p < 0.05) in T1 and T2 after 72 hours incubation of co-culture MSCs with PBMCs from SLE patient.
CONCLUSION: MSCs could decrease the level of IL-12 in PBMCs of human SLE to control the inflammation of SLE disease.
Effect of 0.2% Hyaluronic Acid Gel Topical Application on Healing Period of Oroantral Fistula Treated with Buccal Flap
Authors: Mohammed Nawres Bahaa , Alsaadi Malath Azeez , Sultan Safaa Sahib Naji , Aliakbar Adil
Published: December 2020

BACKGROUND: Oroantral fistula (OAF) is a pathological communication between maxillary sinus and oral cavity, which treated by various surgical methods including buccal flap and associated with post-operative discomfort and relatively long healing period.
AIM: The objective of the study was to evaluate the effect of 0.2% hyaluronic acid (HA) gel on the healing period after surgical buccal flap treatment of OAF.
METHODS: The records of 20 patients of both genders included and reviewed retrospectively. Ten patients treated with topical 0.2% HA gel while the other 10 patients treated without it. Patients healing process followed up for suture removal appointment.
RESULTS: Statistically significant p ≤ 0.05 decreases in healing period when we compare patients treated with topical HA gel and those without topical HA gel.
CONCLUSION: The use of topical HA gel may have advantages for soft-tissue healing and decrease healing period for patients has OAF treated with surgical buccal flap.
Coronavirus Disease-19 Quarantine Experience in the Middle East Region: Emotional Status, Health Patterns, and Self-efficacy Survey
Authors: Hussien Rasha , Shahin Mahmoud Abdul Hameed
Published: December 2020

BACKGROUND: The coronavirus disease (COVID)-19 pandemic can provoke anxiety, stress, sadness, and fear; therefore, the timely assessment of individual psychological health status is urgently necessary for society.
AIM: The aim of the study was to assess the emotional states (depression, anxiety, and stress), functional health patterns, and self-efficacy among individuals from Egypt, Jordan, and Saudi Arabia during the home quarantine experience associated with COVID-19.
METHODS: A descriptive and cross-sectional research design was applied to a convenience sample that included 704 participants from Egypt, Jordan, and Saudi Arabia. Data collection was performed in April 2020, using a self-administered questionnaire that consisted of a sociodemographic data sheet, the Depression, Anxiety, Stress Scale (DASS), a functional health pattern survey, and the General Self-Efficacy Scale (GSES).
RESULTS: Overall, the sample was found to have mild-level DASS scores, with significantly higher scores identified for Egyptian participants compared with those from other countries. In contrast, participants from Egypt presented significantly reduced GSES scores than those from other countries. Higher mean DASS scores were identified among females, participants who reported inappropriate housing conditions and participants who were unemployed, young, widowed, and school-educated. A high mean DASS score was significantly associated with reported disturbances in sleep, sexuality, and social communication, work schedule changes, the inability to concentrate on positive thoughts, the inability to empty their brains of daily thoughts, and not caring about regular interactions with family. Increased mean GSES scores were significantly associated with males, participants who reported appropriate housing conditions, participants who live alone, are older, married, hold higher education degrees, and who are employed with sufficient incomes, whereas lower mean GSES scores were significantly associated with participants who reported engaging in regular exercise, experiencing disturbances in sexuality and social communications, and reduced appetites. However, a significant inverse correlation was detected between the mean DASS and GSES scores, with significant positive correlations among the DASS.
CONCLUSION: The COVID-19 quarantine was associated with a mild level of depression stress and normal anxiety levels, with higher psychological distress and lower self-efficacy identified among participants from Egypt. The emotional status of individuals during the COVID-19 pandemic should be explored further, and awareness programs, designed to address the psychological effects of quarantine, should be promoted, through mass media and other means, with consideration of the effects on the general population, COVID-19 cases, individuals with close contacts with COVID-19 cases, and health-care professionals.
The Emotional State and Physical Condition of Indonesian College Students: An Emerging Situation during the Coronavirus Disease-19 Crisis in Indonesia
Authors: Arundhana Andi Imam , Iqbal Muhammad , Maharani Siti Annisa , Syam Aminuddin
Published: December 2020

BACKGROUND: Since the first cases in Wuhan China have been reported, the Coronavirus disease (COVID)-19 cases increased exponentially over the world. This disease might affect physical and mental well-being.
AIM: This study was aimed to examine the emotional state and physical condition of college students during the COVID-19 pandemic in Indonesia.
METHODS: The study used a cross-sectional survey design in April 2020. The participants of the survey were adult that currently enrolled at one of the universities in Indonesia from diploma-1 to master’s degree. Information from a total of 1044 participants could be obtained. We used the developed self-reported questionnaire to collect information regarding socio-demographic, personal hygiene and healthy lifestyle, anthropometric measurement data, and depressive symptoms. Pearson Chi-square and Fisher’s exact test were performed using SPSS v.24 with a significant level of P < 0.05.
RESULTS: This study found that 31.1% of participants are possible depressed. Of 1044 students, 35.3% were malnourished (16.5% underweight and 18.8% overweight/obese). Factors associated with depressive symptoms are sleep longer than usual, gathering with family members, and working (for income-generating).
CONCLUSION: The COVID-19 probably affected the majority of Indonesian college students, especially for emotional and physical condition. The government should not neglect this group by providing clinical and social supports for their well-being.
Correlation between Interleukin-4 Gene Promoter Polymorphisms with Thyrotropin Receptor Antibody and Transforming Growth Factor-β
Authors: Raveinal Raveinal , Darwin Eryati , Decroli Eva , Jamsari Jamsari
Published: December 2020

AIM: The aim of this study was to determine the correlation between interleukin-4 (IL-4) gene promoter polymorphisms with thyrotropin receptor antibody (TRAb) and transforming growth factor-β (TGF-β).
METHODS: This study was conducted from August 2015 until December 2015 in the internal medicine department in Dr. M. Djamil Hospital, Padang, West Sumatera, Indonesia. Graves’ disease was confirmed by measuring free thyroxine, thyroid-stimulating hormone, and TRAb. We examined that IL-4 promotor gene polymorphism was examined with a polymerase chain reaction. Graves’ disease serum patients will be used to check levels of TGFβ and TRAb antibodies using the enzyme-linked immunoassay method.
RESULTS: There are 15 patients in this study. The average of age in patients group is 40.87 (11.23) years. The number of female patients in this study is more than male patients, with the percentage of women are 73.3%, and men are 26.7%. The sequencing examination on IL-4 gene promoter resulted in 2 single nucleotide polymorphism motifs, which are rs2243250 and rs2070847. The mean TRAb level in wild type and mutant group is 6.77 (5.73) IU/L and 4.66 (3.91) IU/L, respectively. The mean TGF-β levels in wild type and mutant group are 1168.89 (438.91) pg/mL and 1114.79 (296.02) pg/mL, respectively. Statistical tests showed no association between IL-4 gene promoter polymorphisms with TRAb and TGF-β levels (p > 0.05).
CONCLUSION: There is no correlation between IL-4 gene promoter polymorphisms with TRAb and TGF-β.
A global meta-analysis of ITS rDNA sequences from material belonging to the genus Ganoderma (Basidiomycota, Polyporales) including new data from selected taxa
Authors: Fryssouli Vassiliki , Zervakis Georgios , Polemis Elias , Typas Milton A.
Published: December 2020

GanodermaP. Karst. is a cosmopolitan genus of white-rot fungi which comprises species with highly-prized pharmaceutical properties, valuable biotechnological applications and of significant phytopathological interest. However, the status of the taxonomy within the genus is still highly controversial and ambiguous despite the progress made through molecular approaches. A metadata analysis of 3908 nuclear ribosomal internal transcribed spacer (ITS) rDNA sequences obtained from GenBank/ENA/DDBJ and UNITE was performed by targeting sequences annotated asGanoderma, but also sequences from environmental samples and from material examined for the first time.Ganodermataxa segregated into five main lineages (Clades A to E). Clade A corresponds to the core of laccate species and includesG. shanxienseand three major well-supported clusters: Cluster A.1 (‘G. lucidumsensu lato’) consists of taxa from Eurasia and North America, Cluster A.2 of material with worldwide occurrence includingG. resinaceumand Cluster A.3 is composed of species originating from all continents except Europe and comprisesG. lingzhi. Clade B includesG. applanatumand allied species with a Holarctic distribution. Clade C comprises taxa from Asia and Africa only. Clade D consists of laccate taxa with tropical/subtropical occurrence, while clade E harbours the highest number of non-laccate species with a cosmopolitan distribution. The 92Ganoderma-associated names, initially used for sequences labelling, correspond to at least 80 taxa. Amongst them, 21 constitute putatively new phylospecies after our application of criteria relevant to the robustness/support of the terminal clades, intra- and interspecific genetic divergence and available biogeographic data. Moreover, several other groups or individual sequences seem to represent distinct taxonomic entities and merit further investigation. A particularly large number of the public sequences was revealed to be insufficiently and/or incorrectly identified, for example, 87% and 78% of entries labelled asG. australeandG. lucidum, respectively. In general, ITS demonstrated high efficacy in resolving relationships amongst most of theGanodermataxa; however, it was not equally useful at elucidating species barriers across the entire genus and such cases are outlined. Furthermore, we draw conclusions on biogeography by evaluating species occurrence on a global scale in conjunction with phylogenetic structure/patterns. The sequence variability assessed in ITS spacers could be further exploited for diagnostic purposes.
Are Farming and Animal Exposure Risk Factors for the Development of Granulomatosis With Polyangiitis? Environmental Risk Factors Revisited: A Case-control Study
Authors: Lindberg Hanna , Colliander Caroline , Nise Lena , Dahlqvist Johanna , Knight Ann
Published: December 2020

Objective.

To investigate the possible association between animal exposure and risk for granulomatosis with polyangiitis (GPA).

Methods.

Patients with GPA at the Department of Rheumatology, Uppsala University Hospital, between January 1, 2011, and December 31, 2018, were consecutively included. All patients filled in a questionnaire on possible environmental exposures: occupation, hobbies, and animal contact. As controls we included 128 patients with rheumatoid arthritis (RA) and 248 population controls collected from the Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study, matched for age, sex, and geographical area of residence. The controls filled out a questionnaire on current and past contact with farming and animals, at the time of the RA patient’s diagnosis.

Results.

A total of 62 patients with GPA, 128 patients with RA, and 248 population controls were included in the study. GPA was significantly associated with horse exposure, with a 2- to 3-fold increased risk compared with RA (OR 3.08, 95% CI 1.34–7.08) and population controls (OR 2.61, 95% CI 1.29–5.29). Borderline increased risks were found for any animal contact, but no association was found when analyzing contact with cats/dogs only. A significant association was found between GPA and farming compared to the population controls (OR 7.60, 95% CI 3.21–17.93).

Conclusion.

This study has identified for the first time, to our knowledge, a significant association between exposure to specific animals, namely horses, and the development of GPA. The results also support previous studies reporting an association between farming and GPA, underscoring the possibility of exogenous factors as initiators in the development of GPA.
Predicting Macrophage Activation Syndrome in Childhood-onset Systemic Lupus Erythematosus Patients at Diagnosis
Authors: Gerstein Maya , Borgia R. Ezequiel , Dominguez Daniela , Feldman Brian M. , Liao Fangming , Levy Deborah M. , Ng Lawrence , Abdelhaleem Mohamed , Silverman Earl D. , Hiraki Linda T.
Published: December 2020

Objective

Macrophage activation syndrome (MAS), a life-threatening inflammatory complication, is increasingly recognized in childhood-onset systemic lupus erythematosus (cSLE). It can be a challenge to differentiate active cSLE from MAS. We generated decision rules for discriminating MAS from active cSLE in newly diagnosed patients.

Methods

We conducted a retrospective cohort study of consecutive, newly diagnosed, active cSLE patients with fever, requiring hospital admission to The Hospital for Sick Children from January 2003 to December 2007 (cohort 1) and January 2008 to December 2013 (cohort 2). All patients met ≥ 4 American College of Rheumatology or Systemic Lupus International Collaborating Clinics criteria, and were steroid-naïve and infection-free. MAS was diagnosed based on expert opinion. Recursive partitioning was applied to each cohort to derive a decision rule based on clinical and laboratory features, distinguishing MAS from non-MAS cSLE. Each decision rule was applied to the alternate, independent cohort. Sensitivity and specificity of these decision rules were compared to existing criteria.

Results

Cohort 1 (n = 34) and cohort 2 (n = 41) each had 10 patients with MAS. Recursive partitioning in cohort 1 identified ferritin ≥ 699 μg/L as the sole best discriminator between MAS and non-MAS patients (R2 = 0.48), and in cohort 2, ferritin ≥ 1107 μg/L was the best discriminator for MAS, followed by lymphocytes < 0.72 × 103/mm3 (R2 = 0.52). Cross-validation of our decision rules maintained 90–100% sensitivity and 65–85% specificity.

Conclusion

Our decision rule demonstrated improved performance compared to preliminary guidelines for MAS in cSLE from the Lupus Working Group of the Paediatric Rheumatology European Society and familial hemophagocytic lymphohistiocytosis diagnostic criteria. Validation in independent cohorts is required.
Evaluation of the Effect of Diabetes on Rheumatoid Arthritis–related Outcomes in an Electronic Health Record–based Rheumatology Registry
Authors: Yun Huifeng , Xie Fenglong , Chen Lang , Yang Shuo , Ferri Leticia , Alemao Evo , Curtis Jeffrey R.
Published: December 2020

Objective.

Patients with rheumatoid arthritis (RA) who also have diabetes mellitus (DM) might have worse clinical outcomes and adverse events compared to patients with RA who do not have DM. We evaluated the effects of DM on Health Assessment Questionnaire (HAQ) changes and outpatient infection rates in patients with RA.

Methods.

Using the American College of Rheumatology’s Rheumatology Informatics System for Effectiveness (RISE) electronic health record–based registry, we identified patients with RA who had ≥ 1 rheumatologist visit with a HAQ measured in 2016 (index visit), ≥ 1 previous visit, and a subsequent outcome visit with the same HAQ measured at 12 months (± 3 months). We identified DM by diagnosis codes, medications, or laboratory values. Outpatient infection was defined by diagnosis codes or antiinfective medications. We calculated mean HAQ change and incidence rate (IR) of outpatient infections among patients with and without DM. Generalized linear models and Cox regression were used to calculate the adjusted mean HAQ change and HRs.

Results.

We identified 3853 RA patients with DM and 18,487 without DM. The mean HAQ change between index and outcome visit among patients with DM was 0.03 and without DM was 0.002 (P< 0.01). We identified 761 outpatient infections for patients with DM with an IR of 22.6 (95% CI 21.0–24.2) per 100 person-years and 3239 among patients without DM with an IR of 19.8 (95% CI 19.1–20.5). The adjusted HR of outpatient infections among patients with DM was 0.99 (95% CI 0.91–1.07), compared to patients without DM.

Conclusion.

Patients with RA with concomitant DM had greater worsening, or less improvement, in their functional status, suggesting additional interventions may be needed for RA patients with DM to optimize treatment and management of other comorbidities.
Metaanalysis Reveals Genetic Correlates of Osteoporosis Pathogenesis
Authors: Hasan Laith K. , Aljabban Jihad , Rohr Michael , Mukhtar Mohamed , Adapa Nikhil , Salim Rahaf , Aljabban Nabeal , Syed Saad , Syed Sharjeel , Panahiazar Maryam , Hadley Dexter , Jarjour Wael
Published: December 2020

Objective.

Osteoporosis is a growing healthcare burden. By identifying osteoporosis-promoting genetic variations, we can spotlight targets for new pharmacologic therapies that will improve patient outcomes. In this metaanalysis, we analyzed mesenchymal stem cell (MSC) biomarkers in patients with osteoporosis.

Methods.

We employed our Search Tag Analyze Resource for the Gene Expression Omnibus (STARGEO) platform to conduct a metaanalysis to define osteoporosis pathogenesis. We compared 15 osteoporotic and 14 healthy control MSC samples. We then analyzed the genetic signature in Ingenuity Pathway Analysis.

Results.

The top canonical pathways identified that were statistically significant included the serine peptidase inhibitor kazal type 1 pancreatic cancer pathway, calcium signaling, pancreatic adenocarcinoma signaling, axonal guidance signaling, and glutamate receptor signaling. Upstream regulators involved in this disease process includedESR1, dexamethasone,CTNNβ1, CREB1, andERBB2.

Conclusion.

Although there has been extensive research looking at the genetic basis for inflammatory arthritis, very little literature currently exists that has identified genetic pathways contributing to osteoporosis. Our study has identified several important genes involved in osteoporosis pathogenesis includingESR1, CTNNβ1, CREB1, andERBB2. ESR1has been shown to have numerous polymorphisms, which may play a prominent role in osteoporosis. The Wnt pathway, which includes theCTNNβ1gene identified in our study, plays a prominent role in bone mass regulation. Wnt pathway polymorphisms can increase susceptibility to osteoporosis. Our analysis also suggests a potential mechanism forERBB2in osteoporosis through Semaphorin 4D (SEMA4D). Our metaanalysis identifies several genes and pathways that can be targeted to develop new anabolic drugs for osteoporosis treatment.
Feminization of the Rheumatology Workforce: A Longitudinal Evaluation of Patient Volumes, Practice Sizes, and Physician Remuneration
Authors: Widdifield Jessica , Gatley Jodi M. , Pope Janet E. , Barber Claire E.H. , Kuriya Bindee , Eder Lihi , Thorne Carter , Ling Vicki , Paterson J. Michael , Ahluwalia Vandana , Marks Courtney , Bernatsky Sasha
Published: December 2020

Objective.

To compare differences in clinical activity and remuneration between male and female rheumatologists and to evaluate associations between physician gender and practice sizes and patient volume, accounting for rheumatologists’ age, and calendar year effects.

Methods.

We conducted a population-based study in Ontario, Canada, between 2000 to 2015 identifying all rheumatologists practicing as full-time equivalents (FTEs) or above and assessed differences in practice sizes (number of unique patients), practice volumes (number of patient visits), and remuneration (total fee-for-service billings) between male and female rheumatologists. Multivariable linear regression was used to evaluate the effects of gender on practice size and volume separately, accounting for age and year.

Results.

The number of rheumatologists practicing at ≥ 1 FTE increased from 89 to 120 from 2000 to 2015, with the percentage of females increasing from 27.0% to 41.7%. Males had larger practice sizes and practice volumes. Remuneration was consistently higher for males (median difference of CAD $46,000–102,000 annually). Our adjusted analyses estimated that in a given year, males saw a mean of 606 (95% CI 107–1105) more patients than females did, and had 1059 (95% CI 345–1773) more patient visits. Among males and females combined, there was a small but statistically significant reduction in mean annual number of patient visits, and middle-aged rheumatologists had greater practice sizes and volumes than their younger/older counterparts.

Conclusion.

On average, female rheumatologists saw fewer patients and had fewer patient visits annually relative to males, resulting in lower earnings. Increasing feminization necessitates workforce planning to ensure that populations’ needs are met.
Producción científica del Ecuador en el ámbito agropecuario: caso del Instituto Nacional de Investigaciones Agropecuarias, periodo 2014-2019
Authors: Viera-Arroyo William , Sánchez-Arizo Víctor , Merino-Toro Jorge , Domínguez-Andrade Juan
Published: December 2020

La producción científica en Ecuador ha seguido un patrón similar a la evolución de otros países latinoamericanos, existiendo escasa generación de documentos indexados; pero en los últimos años se ha incrementado. El INIAP ha plasmado los resultados de sus investigaciones en publicaciones técnicas, dípticos, guías, manuales, entre otros. Desde el año 2014 ha tenido un aumento sostenido en su producción científica, debido a nueva reglamentación de acreditación e incentivos a investigadores. El objetivo de la presente investigación fue realizar un análisis de la producción científica del INIAP durante el periodo 2014-2019. Los resultados mostraron un aumentó 3,1 veces durante el periodo analizado, superando el crecimiento latinoamericano en ese mismo tiempo. Se determinó que más del 54% de las publicaciones del INIAP tienen colaboración internacional y el 62% de publicaciones están indexadas en revistas con índice SJR. Estos resultados indican que INIAP ha incrementado su producción y calidad científica en investigación agropecuaria.
Revistas iberoamericanas de comunicación a través de las bases de datos Latindex, Dialnet, DOAJ, Scopus, AHCI, SSCI, REDIB, MIAR, ESCI y Google Scholar Metrics
Authors: Gonzalez-Pardo Rafael , Repiso Rafael , Arroyave-Cabrera Jesús
Published: December 2020

El presente trabajo es un análisis de las revistas de Comunicación iberoamericanas, sus características y presencias en Latindex, Dialnet, DOAJ, Scopus, AHCI, SSCI, REDIB, MIAR, ESCI y Google Scholar Metrics - GSM. Se analizan las revistas presentes en estos productos, comparando su cobertura, características, representatividad por países, periodicidad de las cabeceras, antigüedad y producción medida en artículos. El objetivo de este trabajo es identificar las revistas científicas de Comunicación en el ámbito iberoamericano para posteriormente estudiar su presencia en las principales bases de datos de revistas. Se analizan elementos sustanciales como la nacionalidad, naturaleza de las instituciones editoras, periodicidad, producción y antigüedad. Se encuentra que la mayor parte de las revistas provienen de instituciones educativas y con una periodicidad semestral. Latindex es la que mayor número de publicaciones tiene seguida por GSM. Las revistas que pertenecen SSCI y Scopus, son las que mayoritariamente están presentes en las bases de datos de revistas.
Les réformes récentes du code du travail au Brésil et en France : une analyse comparée
Authors: Leite Marcia de Paula
Published: December 2020

Partant de la discussion sur les tendances actuelles du capitalisme au niveau international, cet article analyse les récentes réformes du travail mises en place au Brésil et en France. Le texte met en lumière le recul des acquis sociaux, les changements dans les modalités d’embauche, les transformations au niveau de la négociation entre capital et travail et la fragilisation larvée des syndicats, tout en soulignant les similitudes et les différences dans les deux cas. Cette étude a été menée dans les deux pays sur la base d’une analyse bibliographique et documentaire et d’entretiens avec des chercheurs et des syndicalistes.
Apple Leaf Disease Identification Based on Optimized Deep Neural Network
Authors: Anitha Ruth J.  , Uma R.  , Meenakshi A.
Published: December 2020

Apples are the most productive fruits in the world with a lot of medicinal and nutritional value. Significant economic losses occur frequently due to various diseases that occur on a huge scale of apple production. Consequently, the effective and timely discovery of apple leaf infection becomes compulsory. The proposed work uses optimal deep neural network for effectively identifying the diseases of apple trees. This work utilizes a convolution neural network to capture the features of Apple leaves. Extracted features are optimized with the help of the optimization algorithm. The optimized features are utilized in the leaf disease identification process. Here the traditional DNN algorithm is modified by means of weight optimization using adaptive monarch butterfly optimization (AMBO) algorithm. The experimental results show that the proposed disease identification methodology based on the optimized deep neural network accomplishes an overall accuracy of 98.42%.
Polynomials on the Sierpiński gasket with respect to different Laplacians which are symmetric and self-similar
Authors: Loring Christian , Ogden W. Jacob , Sandine Ely , Strichartz Robert S.
Published: December 2020

We study the analogue of polynomials (solutions to

\Delta u^{n+1}u=0

for some

n

) on the Sierpiński gasket (SG) with respect to a family of symmetric, self-similar Laplacians constructed by Fang, King, Lee, and Strichartz, extending the work of Needleman, Strichartz, Teplyaev, and Yung on the polynomials with respect to the standard Kigami Laplacian. We define a basis for the space of polynomials, the monomials, characterized by the property that a certain “derivative” is 1 at one of the boundary points, while all other “derivatives” vanish, and we compute the values of the monomials at the boundary points of SG. We then present some data which suggest surprising relationships between the values of the monomials at the boundary and certain Neumann eigenvalues of the family of symmetric self-similar Laplacians. Surprisingly, the results for the general case are quite different from the results for the Kigami Laplacian.
Aproximaciones a la antropología filosófica de Juan Abugattás Abugattás
Authors: Rengifo Vela Saúl
Published: December 2020

En lo que sigue, intentaremos una primera aproximación a los escritos antropológicos de Juan Abugattás a partir de losensayos reunidos por la Oficina de Coordinación Universitaria del Ministerio de Educación bajo el título La búsqueda deuna alternativa civilizatoria (Lima, 2005). Dejaremos para un momento posterior el análisis y comentario de otros textosque, desperdigados, se encuentran como valiosas colaboraciones en libros y revistas diversas, a la espera de una labor deedición de la obra en su conjunto del ilustre maestro sanmarquino.

El texto que ahora nos interpela, La búsqueda de una alternativa civilizatoria, se compone de una docena de ensayos,aproximadamente, recopilados temáticamente y siguiendo un orden cronológico, que fueron agrupados en tres secciones opartes: la primera, con el título “Las fuerzas del presente y las posibles formas del futuro: indagaciones filosóficas”, agrupamás de media docena de ensayos; la segunda parte, con el título “Reflexionar sobre el Perú: retos y posibilidades de laacción colectiva”, reúne tres ensayos; y la última sección, “El sentido de la educación en el Perú”, con un par de ensayos.
Intervención educativa de enfermería sobre quemaduras en escolares de una población mexiquense.
Authors: Jilote Sánchez Mariela , Rosales González Berenice Yocelin , Álvarez Orozco María Eugenia , Gutiérrez Rodríguez Cristina Polet , Jaimes Cortés Diana
Published: December 2020

Evaluar las intervenciones educativas de enfermería en quemaduras sobre escolares de 8 a 10 años con una población mexiquense. Investigación cuantitativa, no experimental tipo transversal y descriptivo. De 185 alumnos, se determinan 95 alumnos como muestra a partir de una fórmula de matrices con poblaciones finitas. Se utilizó un cuestionario de 11 ítems dividido en dos partes, contiene preguntas con respuestas de opción múltiple (5 respuestas en su mayoría), 64% de la población conoce que es una quemadura, 51% la forma correcta de clasificar su nivel de gravedad, cifra que coincide con quienes identifican las quemaduras del tipo I (53%). Pero solo 35% sabe como tratarlas.
Predictores de riesgo antropométricos y bioquímicos para enfermedades no transmisibles en estudiantes de enfermería.
Authors: Bueno Brito Cornelio , Brito Delgado Hugo Cesar , Delgado Delgado Josefina , Dávila Hernández Gabriela , Petatan Mendoza Silverio , Pérez Castro Eduardo , Rojas Gil Norma
Published: December 2020

La investigación permitió conocer el riesgo poblacional sobre las posibilidades de desarrollar enfermedades cardiovasculares, diabetes mellitus, síndrome metabólico y otras. El objetivo fue identificar predictores de riesgo antropométricos y bioquímicos para desarrollar enfermedades no transmisibles en estudiantes universitarios de enfermería. Se realizó estudio transversal y participaron 222 estudiantes. La información se obtuvo mediante un instrumento tipo cuestionario anónimo. Se recolectaron datos relacionados con predictores de riesgo antropométricos: peso, talla, índice de masa corporal y circunferencia de cintura; asimismo, predictores de riesgo bioquímicos: glucosa, colesterol, triglicéridos. Los resultados de dichos indicadores revelaron elevadas proporciones de sobrepeso y obesidad; además, niveles significativos de glucosa y triglicéridos, que de manera global indican riesgo potencial cardiometabólico.
Evaluation of antioxidant, anticoagulant and
fibrinolytic activity of medicinal plant extract of
ricinus communis
Authors: Dr. Dhinek A and Dr. Sowmia C
Published: December 2020

The study is aimed to evaluate Phytochemical and antioxidant, anticoagulant and fibrinolytic activity of
ricinus communis. The herb plays a major role in the management of various liver disorders through the
traditional medical practices, followed throughout the world. It is better to use a poly herbal formulation than
a single herb. Alkaloids and Glycosides were present in higher amounts in all extract. Flavonoids and
Steroids were present in higher amounts in ethanol, methanol, aqueous and acetone extract. Carbohydrates,
Tannis and saponins were present in higher amounts in ethanol, methanol and aqueous extract. Phenols and
proteins were present in methanolic extract of ricinus communis. Ascorbic acid- non enzymatic antioxidant
was present in higher amounts in T1 which contained 1ml of extract and lesser amount was present in T2
which contained 0.5ml of the extract. The present study revealed that aqueous, methanol and acetone
extract of ricinus communis shows no hemolysis and have more anticoagulant activity. The ethanol extract
have only mild anticoagulant activity.
Müslümanların Seyahat Motivasyonları: Pozitif Psikoloji Perspektifinden Bir Değerlendirme
Authors: GÜLMEZ Çiğdem
Published: December 2020

Turizm olgusu, farklı ekonomik sınıflara, kültürlere, inanç biçimlerine, yaşam tercihlerine sahip kitleri ilgilendiren çok boyutlu bir faaliyettir. Bu nedenle, turizm interdisipliner bir araştırma konusudur ve psikoloji bilimi bakımından da oldukça önemlidir. Özellikle pozitif psikoloji insanların turizm deneyimleriyle yakından ilgilenmekte, insanların psikolojik iyi oluşları ve turizm deneyimleri arasındaki ilişkiye odaklanmaktadır. Pozitif psikolojinin turizm motivasyonlarına ilişkin ulaştığı sonuçlar Müslüman turistler açısından oldukça önemlidir. Bu çalışmanın temel amacı Müslüman turistlerin seyahat motivasyonlarını pozitif psikoloji perspektifinden değerlendirmektir. Çalışma daha önce yapılmış araştırmalar, geliştirilmiş teoriler çerçevesinde mantıksal çözümlemeler yapan kuramsal bir çalışmadır. Çalışmada öncelikle pozitif psikoloji ve turizm ilişki üzerinde durulmuş, ardından tarihsel olarak Müslümanların seyahatleri ve günümüz Müslümanlarının turizm motivasyonları hedonik ve eudaimonik motivasyonlar temelinde değerlendirilmiştir. Pozitif psikolojiye göre temelinde hedonik turizmin mutluluk üzerine etkisi kısa süreli, eudaimonik turizmin ise daha uzun sürelidir. Pozitif psikolojinin turizm araştırmalarındaki çıktılar ve Kur’an’ın Müslümanları bilgilenmeye, tefekkür etmeye, öğüt almaya, ders çıkarmaya, başkalarıyla ilişki kurmaya, Allah’ın yarattığı düzeni görüp takdir etmeye teşvik eden seyahatle ilgili ayetleri göz önüne alındığında Müslüman turistlerin seyahatlerinin altındaki itici gücün daha çok eudaimonik olması gerektiği söylenebilir.
Street Crime during Covid-19 Pandemic in Perspective of Routine Activity Law Theory and it Influence on Indonesian Criminal Law
Authors: Ida Hasan  , Holy One Singadimedja  , Yogi Yasa Wedha  , Sara Ida Magdalena Awi  , Edy Nurcahyo
Published: December 2020

The initial prediction is that the condition of covid-19 pandemic will shake people's lives in all aspects, and this condition has a great potential for rising crime. With all of its character, it is very interesting to discuss how street crime developed during the Covid-19 pandemic. This study use a mixed research method, where data is collected from facts in the field, legal sources or applied regulations, associated with legal materials obtained from literature review research and overall data obtained from both primary data and secondary data. The conclusion from this research is that street crime during the Covid-19 Pandemic cannot be stated expressly decreased or increased for each region has dynamics that differ from one another according to the characteristics of the region. The correlation of PSBB policy during the Covid-19 Pandemic with the level of street crime in the perspective of routine activity theory can be seen from several street crimes that change the type and location of their objects / targets as well as the increasing number of drug and cybercrime cases that are striking. PSBB conditions during Pandemic Covid-19 against crimes that require a new system that is integrated with the internet, a pattern of punishment with massive amounts of assimilation to reduce the density of prison and a virtual court examination system that should be a part of the criminal justice system in Indonesia
Cacería de puercoespines: políticas públicas para países de renta media
Authors: Cerrilla Mariana , Gaya Luis Andrés
Published: December 2020

La economía creativa es considerada como estratégica para el desarrollo de los países. Su impacto va más allá de un aspecto cultural, contribuyendo de manera importante al valor agregado, empleo y comercio exterior de las economías. A pesar de lo anterior, muchos países en desarrollo no han implementado políticas públicas que lleven al desarrollo de las industrias culturales y creativas. El presente estudio busca analizar la regulación aplicable a la economía creativa en diez países de renta media, con el fin de determinar si ésta influye en la contribución económica que tienen estas industrias en el Producto Interno Bruto y empleo de un país.
КЛИЕНТООРИЕНТИРОВАННОЕ ОБСЛУЖИВАНИЕ КАК СТРАТЕГИЧЕСКИЙ ПРИОРИТЕТ В ДЕЯТЕЛЬНОСТИ ОРГАНИЗАЦИИ СФЕРЫ УСЛУГ
Authors: Никитина Д.Д. , Беклемешева Е.В.
Published: December 2020

В статье рассматриваются основные положения и концепция

клиентоориентированного обслуживания в сфере услуг на примере салона красоты

«А-Студио»: оценка работы салона по результатам опроса по модели SERVQUAL; выявлены

слабые стороны и разработан план мероприятий для внедрения клиентоориентированного

обслуживания.
Mindset Shift in Cyber Pedagogy: A Teacher's Strategy upon Learning from Home
Authors: Kodrat Denny
Published: December 2020

As Covid 19 pandemic hits Indonesia, teaching-learning activities change dramatically. Learning from home becomes the only alternative in conducting distance education. From the earlier, this cyber pedagogy is assumed as an emergency step taken by the government. Consequently, teachers hold the learning process without clear objectives. Many complaints have occurred, and some improvements are proceeded to reinvent the quality of education. As a radical response toward the chaotic situation, this article is aimed at investigating two significant issues. The first is the requirement of mindset shift as the way to solve the cyber pedagogical problem. The second is the teachers' strategy in doing online learning. Theories about distance learning and quality are referred to as library research does. A descriptive qualitative approach was carried out, and in-depth interviews with parents, students, and teachers were taken. The result of the discussion is the mindset shift in teachers, parents, and stakeholders is required. The creative teachers who have good literacy in information technology are needed in running e-learning and conduct interactive learning from home.