bluuebunny/crossref_metadata_2025 huggingface dataset:
Differential Expression and Distribution of Slco4a1 and Slco1b2 in an
Internal Environment Disorder-induced Hepatocellular Carcinoma Mouse
Model
Authors: Luo Haoxuan , Xie Yang , Huang Shan , Zhang Yu
Published: January 2025

Objective:

This study aims to enhance the understanding of underlying mechanisms and potential therapies of the solute carrier organic anion (SLCO) transporter family in internal environment
disorder (IED)-induced hepatocellular carcinoma (HCC). This could lead to new therapeutic strategies
and offer new directions for the creation of new patents for HCC treatment products.

Methods:

The orthotopic transplantation (OT), IED and IED-based OT (IED-OT) mouse models were
established. Expression patterns of Slco4a1 and Slco1b2 were determined using reverse transcriptionquantitative polymerase chain reaction (RT-qPCR), western blotting (WB) and immunohistochemistry
(IHC) in various tissues, including lung, stomach, liver, spleen, kidney, colon, small intestine, HCC tissues and adjacent non-cancerous tissues.

Results:

Animals exhibited symptoms, including weight loss, lethargy, chills, dyspnea, altered hair texture, and gastrointestinal disturbances, confirming the successful establishment of the IED model. The
analysis demonstrated differential expression and tissue-specific distribution of Slco4a1 and Slco1b2,
which are associated with IED-induced changes. These alterations potentially disrupt organ transport
functions, thereby promoting the development of HCC. Additionally, they suggest a role in rebalancing
the tumor microenvironment and mitigating damage resulting from abnormal substance accumulation.

Conclusions:

Changes in SLCO expression and distribution induced by IED may play pivotal roles in
the development of HCC. These findings contribute insights that could inform novel therapeutic strategies against HCC.
Design and Evaluation of 5-Oxo-1,2,4-triazole-3-carboxamide Compounds as Promising Anticancer Agents: Synthesis, Characterization, In vitro Cytotoxicity and Molecular Docking Studies
Authors: Balavanthapu Rajitha , Sastry Vedula Girija
Published: January 2025

Background:

Cancer presents a significant global health challenge, necessitating effective treatment
strategies. While chemotherapy is widely employed, its non-specific nature can induce adverse effects on normal
cells, prompting the exploration of targeted therapies. The 1,2,4-triazole scaffold has emerged as a promising
element in anticancer drug development due to its structural diversity and potential to target cancer cells.

Objective:

This study aims to synthesize and evaluate novel derivatives derived from the 1,2,4-triazole scaffold
for their potential as anticancer agents. Molecular docking techniques are employed to investigate the interactions
between the designed derivatives and specific cancer-related targets, providing insights into potential underlying
mechanisms.

Methods:

The synthesis involves a three-step process to produce 5-oxo-1,2,4-triazole-3-carboxamide derivatives.
Various analytical techniques, including NMR and HRMS, validate the successful synthesis. Molecular docking
studies utilize X-ray crystal structures of EGFR and CDK-4 obtained from the Protein Data Bank, employing the
Schrödinger suite for ligand preparation and Glide's extra-precision docking modes for scoring.

Results:

The synthesis yields compounds with moderate to good yields, supported by detailed characterization.
Molecular docking scores for the derivatives against EGFR and CDK-4 revealed diverse affinities influenced by
distinct substituents. Compounds with hydroxyl, and halogen, substitutions exhibited notable binding affinities,
while alkyl and amino substitutions showed varying effects. The 1,2,4-triazole derivatives demonstrated potential
for targeted cancer therapy.

Conclusion:

The study highlights the successful synthesis of 5-oxo-1,2,4-triazole-3-carboxamides and their diverse
interactions with cancer-related targets. The findings emphasized the potential of these derivatives as candidates
for further development as anticancer agents, offering insights into structure-activity relationships. The
1,2,4-triazole scaffold stands out as a promising platform for advancing cancer treatment with enhanced precision
and efficacy.
Selected Metal (Au, Ag, and Cu) Complexes of N-heterocyclic Ligands as Potential Anticancer Agents: A Review
Authors: Alshamrani Meshal
Published: January 2025

Nitrogen-based organic heterocyclic compounds are an important source of therapeutic agents. About
75% of drugs approved by the FDA and currently available in the market are N-heterocyclic organic compounds.
The N-heterocyclic organic compounds like pyridine, indole, triazoles, triazine, imidazoles, benzimidazoles,
quinazolines, pyrazoles, quinolines, pyrimidines, porphyrin, etc. have demonstrated significant biological activities.
These heterocyclic organic compounds also coordinate with various metal ions and form coordination compounds.
Most of them have shown improved biological activities. The research on the metal complexes of these
compounds reported their significant biological activities. N-heterocyclic-based metal complexes showed outstanding
anticancer activities against different cancer cell lines, including VEGFR-2, HT-29, MDA-MB-231,
MCF-7 K562, A549, HepG2, HL60, A2780, WI-38, Colo-205, PC-3, and other cancer cell lines. Some of these
compounds showed better anticancer activity than cisplatin. In this review, we summarized the anticancer properties
of N-heterocyclic-based gold (Au), silver (Ag), and copper (Cu) complexes and explored the mechanisms of
action and potential structure-activity relationships (SAR) of these complexes. Our goal is to assist researchers in
designing highly potent N-heterocyclic-based Au, Ag, and Cu complexes for the potential treatment of various
cancers.
Anti-metastasis Effects and Mechanism of Action of Curcumin Analog (2E,6E)-2,6-bis(2,3-dimethoxybenzylidene) Cyclohexanone (DMCH) on the SW620 Colorectal Cancer Cell Line
Authors: Che Rahim Nurul Fattin , Hussin Yazmin , Aziz Muhammad Nazirul Mubin , Masarudin Mas Jaffri , Abd Gani Shafinaz , Akhtar Muhammad Nadeem , Nik Abd. Rahman Nik Mohd Afizan , Alitheen Noorjahan Banu
Published: January 2025

Background:

Colorectal cancer (CRC) is the second-leading cause of cancer-related deaths. Curcumin
has been reported to have suppressive effects in CRC and to address the physiological limitations of curcumin, a
chemically synthesized curcuminoid analog, known as (2E,6E)-2,6-Bis (2,3-Dimethoxy benzylidine) cyclohexanone
(DMCH), was developed and the anti-metastatic and anti-angiogenic properties of DMCH in colorectal cell
line, SW620 were examined.

Methods:

The anti-metastatic effects of DMCH were examined in the SW620 cell line by scratch assay, migration,
and invasion assay, while for anti-angiogenesis properties of the cells, the mouse aortic ring assay and Human
Umbilical Vein Endothelial Cells (HUVEC) assay were conducted. The mechanism of action was determined
by microarray-based gene expression and protein analyses.

Results:

The wound healing assay demonstrated that wound closure was decreased from 63.63 ± 1.44% at IC25
treatment to 4.54 ± 0.62% at IC50 treatment. Significant (p<0.05) reductions in the percentage of migrated and
invaded cells were also observed in SW620, with values of 36.39 ± 3.86% and 44.81 ± 3.54%, respectively.
Mouse aortic ring assays demonstrated a significant reduction in the formation of tubes and microvessels. Microarray
and protein profiler results revealed that DMCH treatment has modulated several metastases, angiogenesisrelated
transcripts, and proteins like Epidermal Growth Factor Receptor (EGFR), TIMP-1 (TIMP Metallopeptidase
Inhibitor 1) and Vascular Endothelial Growth Factor (VEGF).

Conclusion:

DMCH could be a potential anti-cancer agent due to its capability to impede metastasis and angiogenesis
activities of the SW620 colorectal cancer cell line in vitro via regulating genes and protein in metastases
and angiogenesis-related signalling pathways.
Exploring the Impact of Extended Amino Acid Supplementation on Body Composition and Psychopathology in Patients with Eating Disorders Undergoing Psycho-Nutritional Rehabilitation
Authors: Napolillo Michela , Ragione Laura Dalla , Iaco Giulia De , Mococci Tania , Sacco Roberto , Marucci Simonetta
Published: January 2025

Background:

Eating disorders are frequently linked to protein-energy malnutrition, resulting
from chronic energy intake reduction, and leading to reduced body weight and altered
body composition. A nutritional approach based on the supplementation with a mixture of essential
amino acids has proven effective in conditions characterized by reduced dietary intake and increased
degradation of endogenous proteins and might also contribute to correct the amino acid deficiency
possibly involved in the pathogenesis of eating disorders.

Objective:

This study aimed to explore the effects of amino acid supplementation in conjunction
with a standard psycho-nutritional rehabilitation program on body composition, symptoms and
psychopathology status in 30 female patients with eating disorders hospitalized at the Residenza
Palazzo Francisci in Todi, Italy.

Methods:

Enrolled patients were divided in two groups receiving amino acid supplementation for
45 and 90 days, respectively. Each patient underwent bioelectrical impedance analysis at baseline,
after 45 days and after 90 days. Validated psychometric tests were administered at study entry and
study end to all enrolled patients.

Results:

Results from bioelectrical impedance analysis suggest that amino acid supplementation
contributes to restoring nutritional and metabolic balance, with effects proportional to the duration
of administration. Conversely, interpreting the effects on psychopathologic state and symptoms
was challenging, probably due to the small sample size and short observation period.

Conclusions:

Prolonged amino acid supplementation may play a role in the management of patients
with eating disorders, favoring the correction of the catabolic state and possibly contributing
to improvement of the psychopathologic state.
The Impact of Climate Change on the Reinforcement Durability of Concrete Bridge Structures
Authors: Alsultani Riyadh , Saber Qahtan Adnan , Al-Saadi Ahmed Ashor , Mohammed Omran I , Abed Sabah Mohammed , Naser Raghda Ali , Hussein Alaa , Muslim Fatima , Fadhil Haneen , Karim Ibtisam R. , Khassaf Saleh I.
Published: January 2025

Background

Climate change poses significant challenges to the durability of concrete bridge structures, particularly regarding the corrosion of reinforcement. Iraq, due to its geographical location, is particularly vulnerable to greenhouse gas emissions, with carbon dioxide (CO2) being the most prominent. The country's heavy reliance on energy resources like coal, gas, and oil exacerbates air pollution, further compounding environmental concerns. Corrosion of reinforcement in concrete infrastructure, including bridges, is primarily driven by the presence of atmospheric CO2. The risk of corrosion increases with rising CO2 levels associated with global warming, leading to potentially catastrophic damage that is costly to repair.

Methods

This study employs a probabilistic technique to predict the damage potential of concrete infrastructure exposed to carbonation resulting from elevated temperatures and CO2 concentrations.

Results

The findings reveal a significant increase in the risk of damage from carbonation in certain regions of Iraq, with potential rises exceeding 400% by 2100. Additionally, rising temperatures elevate the likelihood of chloride impact by up to 15% over the same period. However, these assessments do not consider changes in ocean acidity in marine exposure, which could further exacerbate the effects of climate change on concrete infrastructure.

Conclusion

The results underscore the urgent need for proactive measures to mitigate the impact of rising atmospheric CO2 levels on the durability of bridge structures in the face of climate change.
Micromorphological Features, DNA Barcoding and Nutraceutical Compounds of Two Edible Flowers: Petunia × Hybrida and Verbena Bonariensis
Authors: Copetta Andrea , Marchioni Ilaria , Najar Basma , Bazzicalupo Miriam , Frigerio Jessica , Betuzzi Federica , Ruffoni Barbara , Pistelli Luisa , Cornara Laura , Pistelli Laura
Published: January 2025

Introduction

Petunia × hybrida and Verbena bonariensis are two herbaceous taxa with edible flowers originating from South America. Despite the well-known ornamental value of these taxa, their potential as a food source remains underexplored.

Methods

Therefore, in our study, the flowers of P. × hybrida and V. bonariensis obtained from plants grown organically in a greenhouse were identified via DNA barcoding analysis and investigated to characterize the micromorphological features, composition in nutrients, nutraceutical compounds, and spontaneous emission of volatile compounds. P. × hybrida flowers exhibited greater levels of crude proteins, carotenoids, and antioxidant activity. In contrast, V. bonariensis had a higher content of total soluble sugars, total polyphenols, total flavonoids, and ascorbic acid. The DNA sequences obtained from both taxa returned maximum identity and were submitted to GenBank.

Results

Both taxa displayed characteristic anthocyanin patterns and taxon-specific glandular trichomes, rich in secondary compounds such as terpenoids, mucilages, and polyphenols. The fragrance and flavor detected for these edible flowers were also dependent on taxon-specific VOCs patterns: P. × hybrida VOCs were rich in non-terpene compounds, predominantly comprising esters (61.6%), especially methyl nonadecanoate (21.7 ± 0.3%) and methyl benzoate (12.7 ± 0.3%); V. bonariensis was characterized by terpenoids, particularly the monoterpene hydrocarbon (E)-β-Ocimene (47.6 ± 2.0%).

Conclusion

Our interdisciplinary study provides the first data for the authentication of these taxa. These data underline the high nutraceutical value of these edible flowers and will also be useful in the case of commercial exploitation.
A Mechanistic Review on the Anti-inflammatory Effects of
β-caryophyllene
Authors: Guo Wanyi , Zhang Chuanhai , Yang Xiaonan , Lin Zhongxiao , Huang Huixue , Shu Yongkang , Shentu Jinjun , Xu Youhua
Published: January 2025

Beta(β)-caryophyllene (BCP) is a naturally occurring bicyclic sesquiterpene widely present in essential oils from various spices, fruits, and both medicinal and ornamental plants. This
mini-review primarily covers research progress over the past 20 years (2004-2024) regarding the
anti-inflammatory activities and mechanisms of BCP, focusing on its antioxidant, immunomodulatory, analgesic, and neuroprotective properties. Experimental studies have documented a variety of
pharmacological activities associated with BCP, including anti-inflammatory, antioxidant, analgesic, immunomodulatory, cardioprotective, intestinal protective, neuroprotective, and nephroprotective effects. BCP has shown significant therapeutic potential in treating diabetes, cardiovascular
diseases, inflammatory bowel diseases, ischemia/reperfusion injury, inflammatory disorders, and
neurodegenerative diseases.
Updates on the Anticancer Profile of Lycopene and its Probable Mechanism Against Breast and Gynecological Cancer
Authors: khurana Suman , Sharma Shrestha , Goyal Parveen Kumar
Published: January 2025

Natural substances are gaining interest as anticancer agents nowadays due to the adverse
effects of synthetic drugs. Among various natural substances, lycopene has emerged as a strong antioxidant
agent and has been found to be effective against prostate, breast, colon, ovarian, liver, endometrial
cancers, etc. This article reviews the therapeutic potential and proposed mechanism of action
of lycopene against breast and gynecological cancer from 2005 to now. Experimental studies suggest
that lycopene can inhibit tumor growth by regulating various signaling pathways for cell growth,
arresting the cell cycle, and inducing cell apoptosis. Lycopene is reported to combat breast cancer
specifically via mechanisms, such as regulation of expression of p53 and Bax, suppression of cyclin
D, inhibiting the activation of ERK and Akt signaling pathway, and gynecological cancer via various
signaling pathways such as STAT3, Nrf2, and NF- κB, down-regulation of ITGB1, ITGA5, FAK,
MMP9, and EMT markers, etc.
AeroGlan: A Smart and Sustainable Plant Species Estimator For Organic And Localized Air Filtering
Authors: Mishra Sushruta , Biswas Reetam , Sharma Vandana , Alkhaldi Nora , Saraee Mo , Khan Surbhi Bhatia
Published: January 2025

Introduction:

Human health is significantly compromised by air pollution, especially
by local air quality. The majority of our society spends their lives in a confined geographical location,
which if subjected to air pollution can expose them to long-term air contamination. It is also
possible that poor air quality can pose serious health risks, especially to susceptible individuals
thereby impacting their lifestyle. Air quality can be improved with appropriate plantation, but they
are underutilized. Various air purification devices have been developed in response to the everincreasing
air pollution level.

Method:

However, artificial means of air purification are not very viable in terms of cost, accessibility
to society, and reliable tools to purify air. This research integrates traditional solutions with
modern technology to counter air purification by selectively using plant species and placing them
in desired locations suitable for urban settings. The study aims to measure the constituents of various
air pollutants spanning across regions to identify and accumulate pollution data using IoTbased
smart devices, remit, and feed this information to cloud-based storage for further processing.
In addition, advanced predictive intelligence is utilized to determine the plant species that
can suffice the need for air purification through organic means in a given geographical zone resulting
in enhancement of Air Quality (AQ), with minimal cost, prolonged shelf life, future proof
and non-detrimental consequences.

Results:

Implementation outcome gives a promising outcome. Accurate readings of various air
pollutants are aggregated. Suitable trees are identified to tackle these pollutants and their absorbing
capacity is determined. Various predictive methods are employed and the random forest model
recorded the best results. The sensory units of the model successfully captured the pollutant data
and any major fluctuations were reported. The prediction pipeline recorded a mean precision, recall,
and f-score value of about 0.95, 0.92, and 0.94 respectively while the mean accuracy of 0.965
was also noted. The observed training and validation accuracy with our model were 0.96 and 0.93
respectively.

Conclusion:

Hence, the proposed ‘AeroGlan’ model may be locally applied as an air pollutants
monitoring device and also to suggest suitable plant species required to counter air contamination
in that locality.
Energy Optimization Dispatch for Multiple Interconnected Microgrids with a Low-Carbon Economy Objective
Authors: Jiang Haoyu , Yang Jun , Lu Tao , Wang Jiang , Luo Yashuai
Published: January 2025

Background:

The multi-microgrid interconnection system is an effective method to
solve the problem of distributed energy consumption, enhance the stability and reliability of the
power grid, connect multiple microgrids with the main power grid, and achieve energy sharing
and exchange, thereby improving energy utilization and reducing transaction costs.

Objective:

Develop advanced multi-microgrid energy optimization scheduling strategy, which can
better integrate and utilize renewable energy, reduce carbon emissions, obtain more economic energy
scheduling scheme, and reduce operation and maintenance costs.

Methods:

It achieves a three-layer scheduling strategy by coordinating microgrids with the main
grid, microgrids with other microgrids, and distributed power sources within microgrids. It first
satisfies the maximum consumption of renewable energy in multi-microgrid systems, and then
satisfies the economic scheduling between multi-microgrids and the main grid, thus achieving the
goal of low-carbon economic operation. When scheduling, priority should be given to coordinating
the energy flow among microgrids. When the distributed power sources within a microgrid
cannot satisfy the electricity demand, or when the electricity demand is too low, resulting in the
energy storage system (ESS) being fully charged and leading to an excess of renewable energy,
the interconnection scheduling between microgrids and the main grid should be initiated to
achieve optimal energy sharing scheduling.

Results:

To validate the effectiveness of the proposed model, a case study involving three interconnected
microgrids was conducted. A comparison is made between the proposed optimized dispatch
model and the scenario where microgrids are not interconnected. The results indicate a total
cost reduction of 128.1 CNY and an environmental governance cost reduction of 13 CNY.

Conclusion:

The results demonstrate that the proposed economic dispatch model for interconnected
microgrids reduces both operational and environmental governance costs, enhances the
utilization of renewable energy, decreases pollutant emissions, and aligns with the operational
goals of a low-carbon economy. The feasibility and effectiveness of this method for energy
scheduling in multi-microgrid interconnected systems are verified.
The Role of the Glymphatic System
Authors: Wang Gaiqing , Chen Haiyun , Yang Juan , Wang Jing , Yan Bo , Chen Minglei
Published: January 2025

The glymphatic system, a recently identified waste clearance pathway in the
brain, is crucial for removing waste products and maintaining brain homeostasis.
Similar to the lymphatic system in the body, the glymphatic system operates uniquely
within the brain. Its main role is to clear various waste products, such as metabolites,
proteins, and toxins, from the brain. AQP4 plays a pivotal role in facilitating the
function of this system.
The Target Therapeutic Approach for the BBB
Authors: Wang Gaiqing , Chen Haiyun , Yang Juan , Wang Jing , Yan Bo , Chen Minglei
Published: January 2025

The blood-brain barrier (BBB) is crucial for maintaining the
microenvironment needed for proper neuronal function. BBB breakdown can lead to
immune cell infiltration and uncontrolled movement of molecules and ions,
contributing to neurodegenerative diseases. Repairing the BBB is a key therapeutic
strategy for treating neurological disorders, utilizing methods such as
glucocorticosteroids (GCs) and mesenchymal stromal cells (MSCs). GCs can restore
BBB integrity by regulating tight junction proteins (TJs), while MSCs show potential
in promoting angiogenesis and BBB repair. Although these strategies are promising,
further research is needed to determine their safety and effectiveness for clinical use.
The Regulatory Mechanism for Astrocyte Polarization
Authors: Wang Gaiqing , Chen Haiyun , Yang Juan , Wang Jing , Yan Bo , Chen Minglei , Liang Chuntian
Published: January 2025

Astrocyte polarization is a multifaceted process governed by various
mechanisms such as developmental and environmental cues, transcription factors,
signaling pathways, epigenetic modifications, and interactions with other cells. Gaining
insights into these regulatory mechanisms is vital for unraveling the significance of
astrocytes in brain development and overall brain function.
A Review of Literary Exchange between Joseonand Qing in the 19th Century : Focusing on the Flow of Literary Exchange
Authors:   The Association of DaeDong-Hanmun, Li Chunji
Published: January 2025

This paper examines the overall flow of literary exchanges between Joseon and Qing by reviewing the body of research conducted so far, following Professor Kim Myung-ho’s “Two Paths Theory.” First, the research on 19th-century Joseon-Qing literary exchange has significantly expanded the scope of study, revealing the unprecedentedly active and equal interactions between the two nations. The literary exchanges were primarily shaped by academic and personal networks. In the case of exchanges involving Kim Jeong-hui and the Chusa school literati, academic networks in both Joseon and China naturally facilitated the interactions. Through these exchanges, research shows that Joseon scholars quickly adopted new trends from the Qing literary circles. This included contributing to the development of epigraphy(金石學) in Joseon and introducing mainstream Qing painting styles(正統派畫風), which briefly became popular in Joseon. Next, the exchanges among scholars following the tradition of the Buk-hak school(北學派) started from familial ties in Joseon and attempted to extend these networks into China. Although these efforts did not yield substantial results, they created new human networks that maintained literary ties(文緣) and preserved their tradition. This tradition left behind captivating anecdotes of friendship, which, according to the research, became legendary and served as a medium for confirming mutual affection among literary figures. These interactions inspired new literary creations, sustaining the tradition of literary exchange.
In contrast to previous studies, which primarily focused on the early and mid-19th century, this study highlights the significance of literary exchanges during the late 19th century, particularly those that took place in Joseon during the Imo Incident(壬午軍亂). These interactions are notable for occurring on Joseon soil rather than in Beijing, filling a research gap on the late 19th century. The study also touches on the necessity of expanding research on “minor tributaries”(群小支流), which appear sporadic and isolated. While these require broader investigation, research has thus far focused on prominent figures in the mainstream, thereby broadening the scope of literary exchange studies. Such research underscores the essence of literary exchange, transcending distinctions between China(華) and non-China(夷), as well as barriers of social status and class. This highlights the human connection and true friendship as the foundation of literary exchange. While the study categorizes research for convenience and does not exhaustively review all results, it identifies a common thread across all streams of research: the efforts to continue the exchange traditions established by earlier Buk-hak scholars.
Catalytic Performance of CO:Ni Mixed Oxide Based Catalyst for Green Fuel Synthesis from Biomass Derived Citrullus Colocynthis Oil
Authors: Shrivastava Piyush , Gupta Jharna , Bhatt Rushil , Vetal Aditi S.
Published: January 2025

This study aimed to synthesize nickel oxide (NiO) and cobalt oxide (Co3O4) based catalysts for synthesizing biodiesel from Citrullus colocynthis oil. Cobalt-nickel mixed oxide catalysts made by co-precipitation technique with different Cobalt to Nickel ratios and named Co:Ni (50:50), Co:Ni (67:33), and Co:Ni (33:67). The Characterization of these synthesized catalysts was performed by XRD and SEM analysis. The transesterification process checked the catalytic activity of these catalysts, and it was found that Co:Ni (33:67) gave the maximum yield, i.e., 90%. The experimental conditions for the maximum yield of biodiesel were 65°C temperature, the Molar ratio of methanol to oil to be 9:1, the time required for reaction taken to be 2.5 h, and catalyst loading of 3.5 wt%. Co:Ni (33:67) exhibits strong catalytic activity and stability, making it a viable heterogeneous catalyst for biodiesel synthesis. Five recyclability studies were conducted in the present study. This research's novelty is synthesizing heterogeneous catalysts with varying ratios of cobalt to nickel and comparing their catalytic performance in biodiesel production.
Toward Personalized Digital Experiences to Promote Diabetes Self-Management: Mixed Methods Social Computing Approach
Authors: Singh Tavleen , Roberts Kirk , Fujimoto Kayo , Wang Jing , Johnson Constance , Myneni Sahiti
Published: January 2025

Background

Type 2 diabetes affects nearly 34.2 million adults and is the seventh leading cause of death in the United States. Digital health communities have emerged as avenues to provide social support to individuals engaging in diabetes self-management (DSM). The analysis of digital peer interactions and social connections can improve our understanding of the factors underlying behavior change, which can inform the development of personalized DSM interventions.

Objective

Our objective is to apply our methodology using a mixed methods approach to (1) characterize the role of context-specific social influence patterns in DSM and (2) derive interventional targets that enhance individual engagement in DSM.

Methods

Using the peer messages from the American Diabetes Association support community for DSM (n=~73,000 peer interactions from 2014 to 2021), (1) a labeled set of peer interactions was generated (n=1501 for the American Diabetes Association) through manual annotation, (2) deep learning models were used to scale the qualitative codes to the entire datasets, (3) the validated model was applied to perform a retrospective analysis, and (4) social network analysis techniques were used to portray large-scale patterns and relationships among the communication dimensions (content and context) embedded in peer interactions.

Results

The affiliation exposure model showed that exposure to community users through sharing interactive communication style speech acts had a positive association with the engagement of community users. Our results also suggest that pre-existing users with type 2 diabetes were more likely to stay engaged in the community when they expressed patient-reported outcomes and progress themes (communication content) using interactive communication style speech acts (communication context). It indicates the potential for targeted social network interventions in the form of structural changes based on the user’s context and content exchanges with peers, which can exert social influence to modify user engagement behaviors.

Conclusions

In this study, we characterize the role of social influence in DSM as observed in large-scale social media datasets. Implications for multicomponent digital interventions are discussed.
Implementation of Brief Submaximal Cardiopulmonary Testing in a High-Volume Presurgical Evaluation Clinic: Feasibility Cohort Study
Authors: Carr Zyad James , Agarkov Daniel , Li Judy , Charchaflieh Jean , Brenes-Bastos Andres , Freund Jonah , Zafar Jill , Schonberger Robert B , Heerdt Paul
Published: January 2025

Background

Precise functional capacity assessment is a critical component for preoperative risk stratification. Brief submaximal cardiopulmonary exercise testing (smCPET) has shown diagnostic utility in various cardiopulmonary conditions.

Objective

This study aims to determine if smCPET could be implemented in a high-volume presurgical evaluation clinic and, when compared to structured functional capacity surveys, if smCPET could better discriminate low functional capacity (≤4.6 metabolic equivalents [METs]).

Methods

After institutional approval, 43 participants presenting for noncardiac surgery who met the following inclusion criteria were enrolled: aged 60 years and older, a Revised Cardiac Risk Index of ≤2, and self-reported METs of ≥4.6 (self-endorsed ability to climb 2 flights of stairs). Subjective METs assessments, Duke Activity Status Index (DASI) surveys, and a 6-minute smCPET trial were conducted. The primary end points were (1) operational efficiency, based on the time of the experimental session being ≤20 minutes; (2) modified Borg survey of perceived exertion, with a score of ≤7 indicating no more than moderate exertion; (3) high participant satisfaction with smCPET task execution, represented as a score of ≥8 (out of 10); and (4) high participant satisfaction with smCPET scheduling, represented as a score of ≥8 (out of 10). Student's t test was used to determine the significance of the secondary end points. Correlation between comparable structured surveys and smCPET measurements was assessed using the Pearson correlation coefficient. A Bland-Altman analysis was used to assess agreement between the methods.

Results

The mean session time was 16.9 (SD 6.8) minutes. The mean posttest modified Borg survey score was 5.35 (SD 1.8). The median patient satisfaction (on a scale of 1=worst to 10=best) was 10 (IQR 10-10) for scheduling and 10 (IQR 9-10) for task execution. Subjective METs were higher when compared to smCPET equivalents (extrapolated peak METs; mean 7.6, SD 2.0 vs mean 6.7, SD 1.8; t42=2.1; P<.001). DASI-estimated peak METs were higher when compared to smCPET peak METs (mean 8.8, SD 1.2 vs mean 6.7, SD 1.8; t42=7.2; P<.001). DASI-estimated peak oxygen uptake was higher than smCPET peak oxygen uptake (mean 30.9, SD 4.3 mL kg–1 min–1 vs mean 23.6, SD 6.5 mL kg–1 min–1; t42=7.2; P<.001).

Conclusions

Implementation of smCPET in a presurgical evaluation clinic is both patient centered and clinically feasible. Brief smCPET measures, supportive of published reports regarding low sensitivity of provider-driven or structured survey measures for low functional capacity, were lower than those from structured surveys. Future studies will analyze the prediction of perioperative complications and cost-effectiveness.

Trial Registration

ClinicalTrials.gov NCT05743673; https://clinicaltrials.gov/study/NCT05743673
Capturing Everyday Parental Feeding Practices and Eating Behaviors of 3- to 5-Year-Old Children With Avid Eating Behavior: Ecological Momentary Assessment Feasibility and Acceptability Study
Authors: Pickard Abigail , Edwards Katie , Farrow Claire , Haycraft Emma , Blissett Jacqueline
Published: January 2025

Background

The wide use of smartphones offers large-scale opportunities for real-time data collection methods such as ecological momentary assessment (EMA) to assess how fluctuations in contextual and psychosocial factors influence parents’ feeding practices and feeding goals, particularly when feeding children with high food approaches.

Objective

The main objectives of this study were to (1) assess parents/caregivers’ compliance with EMA procedures administered through a smartphone app and (2) estimate the criterion validity of the EMA to capture children’s eating occasions and parents’ feeding practices. Participant adherence, technological challenges, and data quality were used to provide an overview of the real-time dynamics of parental mood, feeding goals, and contextual factors during eating occasions.

Methods

Parents in the United Kingdom with a child aged 3 to 5 years who exhibit avid eating behavior were invited to participate in a 10-day EMA study using a smartphone app. Of the 312 invited participants, 122 (39%) parents initiated the EMA study, of which 118 (96.7%) completed the full EMA period and the follow-up feasibility and acceptability survey.

Results

Of those parents who completed the EMA study, 104 (87.4%) parents provided at least 7 “full” days of data (2 signal surveys and 1 event survey), despite 51 parents (43.2%) experiencing technical difficulties. The parents received notifications for morning surveys (69.9% response rate), 3 daily mood surveys (78.7% response rate), and an end-of-day survey (84.6% response rate) on each of the 10 days. Over the EMA period, a total of 2524 child eating/food request surveys were self-initiated by the participants on their smartphones, an average of 2.1 times per day per parent (SD 0.18; min=1.7, max=2.3). The majority of parents felt that the surveys made them more aware of their feelings (105/118, 89%) and activities (93/118, 79%). The frequency of daily food requests estimated by parents at baseline was significantly correlated with the frequency of food requests reported daily during the EMA period (r=0.483, P<.001). However, the number of daily food requests per day estimated at baseline (mean 4.5, SD 1.5) was significantly higher than the number of food requests reported per day during the EMA period (mean 3.7, SD 1.1), (t116=18.8, P<.001).

Conclusions

This paper demonstrates the feasibility of employing EMA to investigate the intricate interplay between parental mood, feeding goals, contextual factors, and feeding practices with children exhibiting an avid eating behavior profile. However, the use of EMA needs to be carefully developed and tested with parents’ involvement to ensure successful data collection.
Virtual Reality-Based Framework for ADHD and Comorbid Symptom Assessment: A Pilot Study (Preprint)
Authors: Jeong Harim , Kang Minjoo , Sorenson Kennet , Moore Jacob , Blair Robert James , Leibenluft Ellen , Newcorn Jeffrey H. , Krone Beth , Jeong Singi , Kim Donghee , Hwang Soonjo
Published: January 2025

BACKGROUND

As Virtual Reality (VR) technology becomes increasingly prevalent, its potential for collecting objective behavioral data in psychiatric settings has been widely recognized. However, the lack of standardized methodologies limits reproducibility and data integration across studies, particularly in assessing attention deficit hyperactivity disorder (ADHD) and associated behaviors such as irritability and aggression.

OBJECTIVE

This study examines the utility of VR-based movement data to operationalize core ADHD symptoms (hyperactivity and inattention) and comorbid disruptive behaviors (irritability and aggression), aiming to identify reproducible and clinically actionable metrics.

METHODS

Forty-five children (mean age = 9.06 years, SD = 2.11; 14 female) participated, including 28 diagnosed with ADHD and 17 controls. Seven VR-derived movement variables were analyzed: average speed, acceleration, total distance, area occupied, distance between hands and head, frequency of movement, and time spent still. Correlation and regression analyses identified which variables best predicted ADHD symptoms and comorbid behaviors.

RESULTS

Total distance emerged as the strongest predictor of hyperactivity (β = 0.52, p < 0.01), while average speed was inversely associated with inattention (β = -0.45, p < 0.05) and positively correlated with aggression (β = 0.38, p < 0.05). More frequent but less intense movements predicted lower irritability (β = -0.41, p < 0.05) and aggression (β = -0.36, p < 0.05). These findings highlight consistent patterns, underscoring the potential of VR-derived movement variables as standardized metrics.

CONCLUSIONS

This study emphasizes the importance of standardized VR methodologies to enhance reproducibility and data integration in psychiatric research. By identifying specific movement variables that reliably predict ADHD and comorbid behaviors, the findings establish a foundation for developing scalable VR tools for clinical assessment and intervention.
TANTANGAN PENERAPAN REKAM MEDIS ELEKTRONIK UNTUK UNIT RAWAT JALAN DI RUMAH SAKIT
Authors: Endah Rusdiana  , Guardian Yoki Sanjaya
Published: January 2025

Latar belakang: Penerapan RME dapat mempermudah pekerjaan, mempercepat pencarian data, dan memudahkan pertukaran informasi.      Untuk mencapai manfaat jangka panjang dari sistem RME, rumah sakit perlu memperhatikan faktor utama yaitu manusia sebagai pengguna, organisasi, dan teknologi.
Tujuan: Mengevaluasi penerapan Rekam Medis Elektronik di unit Rawat Jalan RSU Purbowangi, dan potensi permasalahan yang dihadapi dengan mempertimbangkan faktor manusia, organisasi dan teknologi.
Metode: Penelitian ini menggunakan metode kualitatif dengan pendekatan studi kasus. Kerangka HOT Fit digunakan untuk mengevaluasi penerapan RME rawat jalan di RSU Purbowangi pada bulan Mei-Juni 2024. Penelitian ini melibatkan 18 orang staf pengguna RME di rumah sakit secara purposif. Data diperoleh melalui wawancara mendalam, observasi, dan studi dokumentasi terkait penerapan Rekam Medis Elektrronik.
Hasil: Hasil penelitian menunjukkan bahwa      penerapan RME belum sepenuhnya meningkatkan kualitas layanan, belum dapat dimanfaatkan untuk pelaporan dan evaluasi kualitas pelayanan, serta belum dapat meningkatkan efisiensi dan patient safety. Masih terdapat beberapa hambatan antara lain tingkat penggunaan masih kurang, belum ada tata kelola organisasi IT, sarana dan prasarana yang belum memadai, dan pengembangan fitur belum maksimal.
Kesimpulan: RME belum optimal digunakan di rumah sakit. Strategi dan perencanaan yang menyeluruh sangat dibutuhkan untuk meningkatkan penggunaan RME terutama pada pemenuhan infrastruktur, pelatihan, dan pembentukan unit IT agar manfaat dari RME dapat dimaksimalkan.
Exploring Disability Narratives: The Interplay of Mythology, Realism, and Representation in Literature and Media
Authors: Singh Dr. Smriti
Published: January 2025

Disability narratives serve as a bridge between myth and realism, offering a profound lens through which to examine human diversity and societal constructs. While mythological depictions often reduce disability to symbolic archetypes—representing moral flaws, divine punishment, or extraordinary wisdom—realist narratives ground disability in the lived experiences of individuals, highlighting systemic injustices and cultural biases. This evolution in representation dismantles stereotypes, portraying disabled individuals as complex, multifaceted members of society. Works like Dickens’ Bleak House or Harper Lee’s To Kill a Mockingbird challenge reductive tropes, fostering empathy and broader understanding. Disability narratives thus underscore the importance of inclusivity, revealing how race, class, and gender intersect with disability. By engaging with these stories, literature not only critiques societal norms but also champions equity and dignity. In doing so, disability narratives inspire a reevaluation of cultural values, enriching both literary discourse and social consciousness.
Volver a las leyes del inca y asentar el buen gobierno; a propósito del Parecer cerca de la perpetuidad y buen gobierno de los indios del Perú y aviso de lo que deben hacer los encomenderos para salvarse (1563)
Authors: Morong-Reyes German , Gloël Matthias
Published: January 2025

In 1563, and in the middle of the debate on the perpetuity if the encomiendas in Peru (1560-1570), a formal opinion was sent to the president con the Council of the Indies, Juan Sarmiento (ca. 1518-1564). This writing with the title Parecer cerca de la perpetuidad y buen gobierno de los indios del Peru y aviso de lo que deben hacer los encomenderos para salvarse –which’s author remains unknown– constitutes a theoretical elaborated answer, contrary to the reports and formal opinions of the dominican friars that promoted the end of the encomienda system, since they were directly responsible for the abuses, exploitations and misery of the Indigenous. In this article we analyze this document within the context it was written in, in order to weigh the need to maintain the privileges and traditions of the natives for the exercise of good government. Our main hypothesis states that this text, together with a considerable set if official secular and religious texts, at the service of good government and the establishment of christian policy in the Peruvian kingdoms, is part of a general discourse, which during the decade from 1560 to 1570 emphasized in a positive way the practices of Inca government.
Arguing About Arguing with Arguments
Authors: Siegel Harvey
Published: January 2025

Abstract: I am most grateful to the editors of Informal Logic for their willingness to publish my absurdly long paper (Siegel 2023a) in its entirety, and for organizing the four commentaries published along with it. I am grateful as well to Bart Garssen, Andrew Aberdein, Paula Olmos and Christoph Lumer for their insightful and challenging discussions. In what follows I respond to their criticisms and suggestions in the order in which they appear in the journal.
 
Résumé: Je suis très reconnaissant aux éditeurs d’Informal Logic pour leur volonté de publier mon article absurdement long (Siegel 2023a) dans son intégralité et pour avoir organisé les quatre commentaires publiés avec lui. Je suis également reconnaissant à Bart Garssen, Andrew Aberdein, Paula Olmos et Christoph Lumer pour leurs discussions perspicaces et stimulantes. Dans ce qui suit, je réponds à leurs critiques et suggestions dans l’ordre dans lequel elles apparaissent dans la revue.
Jornada de innovación curricular y buenas prácticas pedagógicas 2024: XI versión
Authors:   Vicerrectoría Académica. Unidad de Gestión y Desarrollo Docente
Published: January 2025

Este libro es una recopilación de prácticas pedagógicas innovadoras desarrolladas por académicas y académicos de la Universidad de Valparaíso, quienes, en el marco del nuevo Modelo Educativo, han contribuido al fortalecimiento de la enseñanza universitaria. Las experiencias recogen el espíritu colaborativo y transformador de la comunidad docente, destacando su compromiso con el aprendizaje significativo y el bienestar integral de la comunidad universitaria. La estructura del libro se organiza en torno a cuatro ejes principales: desarrollo y evaluación de experiencias didácticas para un aprendizaje significativo, bienestar de la comunidad universitaria, integración de la inteligencia artificial en el proceso de enseñanza y aprendizaje y mejoramiento continuo y seguimiento curricular.
ANALISIS FIKIH MUAMALAH TERHADAP POTENSI JUDI DALAM TRADING SAHAM DI BURSA EFEK INDONESIA
Authors: Zuinan Nisa  , Azka Amalia Jihad
Published: January 2025

This article aims to analyse stock trading activities on the Indonesia Stock Exchange (IDX) according to muamalah jurisprudence. The research method used is qualitative with a descriptive-analytical approach, which focuses on an in-depth understanding of the phenomenon by emphasizing its meaning and implications. This study explores the concept of muamalah jurisprudence, relevant sharia principles, and how the principles can be applied in the mechanism of stock trading in the capital market. The results of this study indicate that conducting trading practices using only technical analysis can be classified as gambling behaviour. This is because the practice contains elements of gambling and speculation which are strictly prohibited in Islam. This gambling element arises because decisions taken in trading are based on short-term price movements without considering the real conditions of the company, so that it is more similar to a game of chance. Therefore, to avoid elements of gambling and speculation that are not in accordance with sharia principles, capital market players are advised to combine technical analysis with fundamental analysis. Thus, they can understand the condition of the company more comprehensively, including financial aspects, performance and business prospects, so that the decisions taken become more rational and orderly. This step not only minimizer potential losses, but also ensures that trading activities remain within the corridor of sharia which is ethical, fair and responsible.
Limitations of Observation: Luhmann and the Problem of Paradoxes in Cognition
Authors: Sapan I. E.
Published: January 2025

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Where Myths Are Born. Book Review of: Shnirelman V.A. (2024) In pursuit of ancestors: Ethnogenesis and politics, Moscow; St. Petersburg: Nestor-History
Authors: Verkhovtsev D. V.
Published: January 2025

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