bluuebunny/crossref_metadata_2025 huggingface dataset:
HISTO-PATHOLOGICAL SPECTRUM OF SKIN LESIONS IN TERTIARY CARE CENTRE: A THREE YEAR STUDY
Authors:   Junior Resident, Department of Pathology, Shridevi Institute Of Medical Sciences And Research Hospital Tumkur 572106., C.M Vandhana , V. Achalkar Gireesh ,   Professor and HOD Department of Pathology, Shridevi Institute of Medical Sciences and Research Hospital Tumkur 572106.
Published: May 2023

Introduction: The largest sensory organ of human body is the skin, which accounts for about 15% of total body weight. It is a complex organ having multiple functions. Primarily it acts as a barrier against various harmful environmental agents (1).Skin diseases affect all age groups and are much common in developing countries. In the field of dermatology, 2000 different skin diseases are well known(2) Objectives: The objectives of the study were as follows: (1) To estimate the prevalence of various non-neoplastic and neoplastic skin lesions in our tertiary care hospital. (2) To study the age and sex-wise distribution of non-neoplastic and neoplastic skin lesions. Methods: The present study comprised a total of 102 skin biopsies of non-neoplastic lesions and neoplastic skin lesions, relevant data like age, sex, and sites of skin lesion were obtained from request forms provided to histopathology section. Specimens received were fixed in 10% formalin. Biopsy bits were submitted as whole and processed in automated tissue processor for routine paraffin embedding. Results: Out of 102 biopsies that were analyzed, most belonged to 21- 60years with slight male predominance with a total of 85 cases being Non-Neoplastic skin lesions, of which Chronic dermatitis 18 (28.5%) was the most common histopathological diagnosis, followed by Hansens disease 21(24.7%) among granulomatous skin disease, and a total of 17 cases of neoplastic skin lesions were identified of which dermatofibroma 2(11.8%) and eccrine spiradenoma 2(11.8%) were the benign variants , and Squamous cell carcinoma 3(17.6%) was the most common malignant variant. Conclusion: Histopathological evaluation of skin biopsies holds gold standard technique for diagnosing various skin lesions and their microscopic evaluation helps in assessing variegated morphological features of different types of skin lesions.
COVID ET QT : ETAT DES LIEUX
Authors:   Service De Cardiologie, CHU Mohammed VI Marrakech., Ztati M. , Karimi S. El ,   Service De Cardiologie, CHU Mohammed VI Marrakech., Elhattaoui M. ,   Service De Cardiologie, CHU Mohammed VI Marrakech.
Published: May 2023

Introduction During the current COVID-19 pandemic, there has been increased interest in using off-label medications for treatment of the novel coronavirus (SARS-CoV-2), including drugs with a propensity for QT prolongation such as hydroxychloroquine and azithromycin.(1) to evaluate and manage the QT interval in patients undergoing therapy Materials and methods: A prospective study of 156 Covid patients In all department of the Mohammed VI university hospital in Marrakech during the period from 1 April 2020 to 15 April 2020. RÃ©sultats: Conclusion: Les theÌrapies pour COVID-19 peuvent entraiÌ‚ner des effets indeÌsirables cardio- vasculaires aÌ€ la phase aigueÌˆ potentiellement graves et neÌcessitant une surveillance rapprocheÌe surtout de l interval QT par l electrocardiogramme.
AGRICULTURE URBAINE: POURVOYEUSE DE DENREES ALIMENTAIRES ET SOURCES DE NUISANCES SANITAIRES AU QUARTIER SODEPRA A KORHOGO (NORD DE LA COTE DIVOIRE)
Authors:   Maitre-Assistant, Departement de Geographie, Universite Peleforo GON COULIBALY, Korhogo, Cote dIvoire., Moussa COULIBALY
Published: May 2023

Urban agriculture is an activity that is developing more and more throughout the city of Korhogo, more specifically in the Logokaha district. Undeveloped areas and low-lying areas in the heart of the neighborhood are being invaded by farmers. The objective of this study is to show the impact of urban agriculture on food production and the health of farmers.To achieve this objective, the methodology was based on documentary research and field survey. The field survey was conducted among 81 farmers using the snowball method.The results show that urban agriculture is generally practiced by women (85.19%) without any level of education (71.61%) who squat the spaces. To improve production, farmers use various types of fertilizers (chemical and biological) and pesticides. The time between two consecutive applications is not respected by the farmers. The packaging of chemical products used is thrown away in the immediate environment by 59.26% of farmers. The products of this agriculture are intended for consumption and sale. Despite its contribution to the empowerment of farmers, it exposes farmers to health problems such as fatigue (53.09%), injuries (25.92%), skin burns (11.11%) and pathologies (dry coughs and colds (32.10% of respondents), and diarrheal diseases (19.75%).In order to increase production and reduce health risks, a resilient, healthy and sustainable production system must be put in place, which requires the involvement of all actors (producers, traders and consumers).
HAND HYGIENE AUDIT TO STUDY ADHERENCE TO HAND HYGIENE IN A TERTIARY CARE HOSPITAL
Authors:   PG Student, Department of Microbiology, Apollo Institute of Medical Sciences and Research, Hyderabad., B. Swathi , G. Pavani ,   Professor, Department of Microbiology, Apollo Institute of Medical Sciences and Research, Hyderabad., Dass S. Manick ,   Professor& HOD, Department of Microbiology, Apollo Institute of Medical Sciences and Research, Hyderabad.
Published: May 2023

Introduction:Hands are the main pathways of germ transmission during health care. Regular monitoring of adherence to Hand hygiene is very important to prevent hospital acquired infections. Direct observation method for WHOs 5 moments of hand hygiene is still the gold standard to provide qualitative & quantitative information about when and why failures in hand hygiene occur. Material & Methods:A Prospective observational study was conducted from September 2022 to January 2023. Adherence to Hand hygiene was observed in 33 areas of a tertiary hospital. A total of 500 Health care workers are included in the study. Each area was observed for 5 days in a month for 1 hour. Hand hygiene complete adherence rate & partial adherence rate was calculated & analysed .Compliance to WHO moments of hand hygiene was also observed. Results: Hand hygiene complete adherence rate(HHCAR) was 52%, Hand hygiene partial adherence rate( HHPAR )was 30.5% & non adherence rate was 17.5%. Adherence to WHO moments 1 & 5 was 30.2 & 33.6%. Adherence to moments 2,3,4 was 40.7%, 45.6% & 42.9% respectively. Conclusion:Despite adequate hand hygiene facilities, Hand Hygiene compliance remains low in student nurses and interns.Regular training programmes on Hand hygiene in hospitals should focus on WHO moments 1 & 5 in particular.
Legal Protection Urgency for MSMEs Actors as well as Partnership Program which are Regulated according to Law Number 11 of 2020 on Job Creation
Authors: Nida Salwa
Published: May 2023

The constitution (UUD 1945) gives recognition of human rights to develop themself and exists legal protection of the rights. This article attempts to provide a normative-juridical explanation about how Micro, Small, and Medium Enterprise (MSMEs) gets legal protection through omnibus law and government regulation supporting it. Law number 11 of 2020 about job creation, familiar with omnibus law, is formed to improve and to expand the economic sector. One of the omnibus law aims is to give ease of licensing to MSMEs to enrol the business activities. MSMEs are considered very helpful to create jobs, leading to the rising national economy. Therefore, MSMEs is given the opportunity to be a legal person and to be a private enterprise. The other protections of omnibus law for MSMEs are services of legal aid and legal protection in expanding the business activities by partnership programs with big enterprises. There are about 10 partnership programs among MSMEs and big enterprises. Looking from this form of written laws, this omnibus law is the part of legal protection for MSMEs, either business actors or business enterprises.Undang-Undang Dasar Tahun 1945 memberikan pengakuan terhadap hak warga negara untuk mengembangkan dirinya serta perlindungan hukum atas hak tersebut. Artikel ini berusaha memaparkan secara normatif-yuridis terkait bagaimana UMKM mendapat perlindungan hukum melalui UU Cipta Kerja serta peraturan pemerintah yang mendukungnya. Undang-Undang No 11 Tahun 2020 tentang Cipta Kerja atau yang dikenal dengan omnibus law dibentuk dengan tujuan untuk memperbaiki dan memperluas sektor ekonomi. Salah satunya ialah dengan memberikan kemudahan perizinan bagi UMKM dalam mendaftarkan kegiatan usahanya. UMKM dinilai sangat membantu terciptanya lapangan pekerjaan sehingga meningkatkan perekonomian negara. Oleh karena itu, UMKM juga diberikan peluang untuk berbadan hukum dan menjadi perseroan perorangan. Perlindungan lain yang diberikan dari undang-undang ini adalah adanya layanan bantuan hukum bagi UMKM dan perlindungan hukum dalam memperluas kegiatan usaha UMKM melalui program kemitraan, ada sekitar 10 program kemitraan UMKM Bersama usaha besar. Melihat dari bentuk aturannya yang tertulis, maka undang-undang cipta kerja ini adalah bagian dari perlindungan hukum bagi pelaku usaha dan badan usaha UMKM. Artikel ini berusaha memaparkan secara normatif-yuridis terkait bagaimana UMKM mendapat perlindungan hukum melalui UU Cipta Kerja serta peraturan pemerintah yang mendukungnya.
Animal Abuse in the Perspective of Positive Legal and Islamic Criminal Law
Authors: Sahira Inka , Rosyid Maskur
Published: May 2023

Massive cases of animal abuse occur and are left unchecked, requiring more attention. This article aims to analyze cases of dog abuse in the perspective of positive law in Indonesia and Islamic criminal law. This article is qualitative with a normative juridical legal research method and is presented descriptively. Field case data were obtained through interviews with dog lover’s communities, police, and former dog slaughterers in Yogyakarta. This article finds that the criminal act of molesting dogs at slaughterhouses in Yogyakarta has fulfilled the criminal element of violating Law no. 41 of 2014 concerning Amendments to Law No. 18 of 2009 concerning Livestock and Animal Health and Government Regulation no. 95 of 2012 concerning Veterinary Public Health and Animal Welfare. Mistreatment of dogs has fulfilled the elements of an act called jarīmah and is subject to ta'zīr whose punishment provisions are the authority of the government. So that according to both perspectives, animal abuse is a criminal act and deserves punishment. The omission of the case proves that the law is not implemented properly. This article recommends all parties to participate in guarding and monitoring the welfare and safety of animals from acts of abuse.Kasus penganiayaan hewan yang massif terjadi dan terbiarkan, membutuhkan perhatian lebih. Artikel ini bertujuan untuk mengalisis kasus penganiayaan anjing dalam perspektif hukum positif di Indonesia dan hukum pidana Islam. Artikel ini bersifat kualitatif dengan metode penelitian hukum yuridis normatif dan disajikan secara deskriptif. Data kasus lapangan didapatkan melalui wawancara dengan komunitas pecinta anjing, Polsek Pundong, dan mantan jagal anjing di Yogyakarta. Artikel ini menemukan bahwa tindak pidana penganiayaan anjing di rumah jagal di Yogyakarta telah memenuhi unsur pidana melanggar UU No. 41 Tahun 2014 tentang Perubahan Atas UU No. 18 Tahun 2009 tentang Peternakan dan Kesehatan Hewan dan PP No. 95 Tahun 2012 tentang Kesehatan Masyarakat Veteriner dan Kesejahteraan Hewan. Penganiayaan anjing telah memenuhi unsur-unsur suatu perbuatan disebut jarīmah dan dikenakan ta’zīr yang ketentuan hukumannya menjadi wewenang pemerintah. Sehingga menurut kedua perspektif, tindakan penganiayaan hewan merupakan tindakan pidana dan layak mendapatkan hukuman. Pembiaran kasus membuktikan bahwa hukum tidak terlaksana dengan baik. Artikel ini merekemondasikan kepada semua pihak untuk ikut serta mengawal dan mengawasi kesejahteraan dan keamanan hewan dari tindakan penganiayaan.
Relevance of the Position of the Victims in Indonesian Positive Law and Islamic Criminal Law
Authors: Royani Yayan Muhammad
Published: May 2023

The position of the victim in the criminal justice system is not considered as a subject or object. These problems are inseparable from the understanding that criminal law only regulates the relationship between the state and individuals. Positive laws governing the position of victims are contained in the Criminal Code and Criminal Procedure Code as well as regulations outside the criminal justice system. The regulation is very limited to the victim as a legal object, not a determinant. In the perspective of Islamic law, the position of the victim is regulated in the crime of qisas and takzir. Victims get the right to determine punishment for criminals by implementing qisas, forgiveness or diyat. In the takzir crime, the ruler or judge can determine to compensate the victim as a forgiving or reducing crime. This research is a normative juridical research with a comparative approach. The results of the study indicate that there are similarities and differences in the regulation regarding the position of victims in positive law and Islamic law. Equality lies in the types of rights received by victims in the form of material compensation, compensation, restitution and rehabilitation except in takzir in the form of a decision to marry a rape victim. The difference lies in the position of the victim in positive law which does not include the victim as part of the criminal justice system, while in Islamic law as in qisas, the victim is an inseparable part of the criminal justice system.Kedudukan korban dalam sistem peradilan pidana tidak dianggap sebagai subjek ataupun objek. Permasalahan tersebut tidak terlepas dari pemahaman bahwa hukum pidana hanya mengatur hubungan antara negara dan individu. Hukum positif yang mengatur tentang kedudukan korban terdapat dalam KUHP dan KUHAP serta regulasi di luar sistem peradilan pidana. Pengaturannya sangat terbatas kepada korban sebagai objek hukum bukan penentu. Dalam perspektif hukum Islam kedudukan korban diatur dalam tindak pidana qisas dan takzir. Korban mendapatkan hak sebagai penentu hukuman bagi pelaku tindak pidana dengan pelaksanaan qisas, pemaafan atau diyat. Pada tindak pidana takzir penguasa atau hakim dapat menentukan mengganti kerugian korban sebagai pemaaf atau pengurang tindak pidana. Penelitian merupakan penelitian yuridis normatif dengan pendekatan perbandingan. Hasil penelitian menunjukkan bahwa terdapat persamaan dan perbedaan pengaturan tentang kedudukan korban dalam hukum positif maupun hukum Islam. Persamaan terletak pada jenis hak yang diterima korban berupa pengganti kerugian materi, konpensasi, restitusi dan rehabilitasi kecuali dalam takzir berupa putusan untuk menikahi seorang korban perkosaan. Perbedaan terletak pada kedudukan korban dalam hukum positif yang tidak memasukan korban bagian dalam sistem peradilan pidana, sedangkan dalam hukum Islam sebagaimana qisas, korban merupakan bagian yang tidak terpisahkan dari sistem peradilan pidana
Опыт использования интерактивных кейсов при изучении курса нормальной физиологии в медицинском вузе
Authors: Ткаченко П. В. , Белоусова Н. И. , Петрова Е. В.
Published: May 2023

В статье представлен опыт кафедры нормальной физиологии Курского государственного медицинского университета по применению кейс метода (case study) при обучении. Показаны этапы решения поставленных задач, отмечены положительные моменты использования современных цифровых дистанционных технологий в формировании компетенций и освоении практических умений и владений будущего специалиста-врача.
Изучение факторов, влияющих на практическое применение интерактивных технологий в обучении студентов МФК КГМУ
Authors: Ивлева Е.В. , Котова Д.В. , Кустова В.В.
Published: May 2023

В статье представлены результаты исследования (выявленные факторы применения интерактивных форм, проблемы и пути решения), которые можно использовать в дальнейшем в процессе обучения преподаваемых дисциплин.
Проектная деятельность в образовании: на примере реализации национальной программы образования (Узбекистан)
Authors: Абдурахманова А.Т.
Published: May 2023

В статье представлены результаты теоретического анализа проектной деятельности, ее этапов, а также результатов внедрения проектной деятельности в образовательный процесс. На примере национальной программы образования Узбекистана описан успешный опыт реализации проектной деятельности – создание и реализация проекта «Школа лидеров».
Ресурс краеведческих исследований в обучении студентов медицинского вуза: опыт поиска краеведческой информации по истории медицины
Authors: Зверева Е.Е. , Зяблицкая Е.Ю. , Кутя С.А.
Published: May 2023

В статье охарактеризована польза краеведческих исследований на медицинскую тематику для обучения студентов медицинских вузов. Историческое наследие дает почву для патриотического воспитания студентов, поскольку акцентирует их внимание на известных и забытых именах врачей-соотечественников, которые оставили значительный вклад в развитие медицины. Описан опыт проведения краеведческого поиска силами не профессионалов-историков и краеведов, а преподавателями и студентами кафедры в Крыму. Крым имеет богатое историко-культурное наследие и огромный потенциал для краеведческой работы. Отмечена тенденция популяризации краеведческих знаний, проведения тематических экскурсий, как профессиональными историками, так и краеведами-любителями. В работе отмечены методики, которые оказались эффективными и позволили собрать массив исторической информации. Описаны результаты работы и указаны способы применения и внедрения их в образовательный процесс кафедры. В настоящее время на базе найденных фактов ведется формирование музейного экспозиционного социокультурного пространства. Краеведческие исследования по истории медицины имеют значительный потенциал для патриотического и нравственного воспитания будущих врачей.
THE FIRST PUBLICATION IN THE PUBLICATIONS OF THE RUSSIAN SCIENCE CITATION INDEX DATABASE: METHODOLOGICAL GUIDANCE FOR STUDENTS
Authors: Garaev T.K. , Yakupov Z.Y. , Galimova R.K. , Gizitdinova E.A.
Published: May 2023

Considering trending attraction of young candidates to scientific research work a brief guide is presented to assist them in preparation of completed work in the shortest possible time, in selection of the appropriate journal, and in publication of the results in journals of the Russian Science Citation Index (RSCI).
STUDENTS’ DESTRUCTIVE BEHAVIOURS AND SOLUTIONS TO OVERCOME IT
Authors: Binti Mohd Hasnafiah S. , Filippovich M.S.
Published: May 2023

The article is devoted to highlight some destructive behaviours among students of the medical universities.
Metodologias Ativas no Ensino-Aprendizagem de Práticas Antirracista na Enfermagem
Authors: Silva Luciana Silvério Alleluia Higino da , Tavares Claudia Mara de Melo , Paiva Laís Mariano de , Silva Thiago Nogueira , Ferreira Matheus Marques
Published: May 2023

Introdução: Falar sobre racismo na enfermagem é um desafio, pois é uma profissão que se construiu sob a ótica europeia, branca e cristã. No que concerne à formação, se percebe duas barreiras de acesso à educação antirracista – a primeira seria a baixa abordagem de temática nos espaços formativos e a segunda indica as resistências em reconhecer que a estrutura é racista e por isso as pessoas negras têm dificuldade em se inserir nos espaços de formação. Neste sentido, as metodologias ativas podem indicar uma oportunidade de aprendizado vivo para reflexões em ato da experiência vivida. Método: Trata-se de um relato de experiência sobre o uso de metodologias ativas para aprendizagem de práticas antirracistas na enfermagem. Resultados: A expressão “somos todos iguais” não contempla a existência da igualdade racial. É preciso que os docentes criem estratégias de inclusão e discussão sobre racismo, multirracialidade e igualdade racial além de apresentar a ética profissional essencial no cuidado de enfermagem. Discussão: Existe a necessidade de aporte teórico que sustente práticas que valorize a pessoa a ser cuidada, respeitando sua singularidade racial, cultural e social. Participantes relataram que a falta de discussões como esta, dificulta uma formação completa. Considerações finais: O uso das metodologias ativas para ensinar práticas antirracistas colabora com práticas mais humanas e fortalece a dimensão política e social além de evitar problemas de ética para os futuros profissionais.
Palavras-Chave: Racismo Institucional; Educação em Enfermagem; Aprendizagem Baseada em Problemas.
Introduction of Novel Drug Targets against Staphylococcus aureus and Proposing
Putative Inhibitors against Adenine N1 (m1A22)-tRNA Methyltransferase (TrmK)
using Computer-aided Drug Discovery
Authors: Beig Masoumeh , Ebrahimi Tahereh , Goodarzi Narjes Noori , Fereshteh Sepideh , Habibi Mehri , Badmasti Farzad
Published: May 2023

Background:

Nowadays, the emergence of methicillin-resistant Staphylococcus aureus (MRSA) and
vancomycin-resistant S. aureus (VRSA) strains has dramatically restricted the treatment options against this
microorganism.

Aim:

In this study, we aimed to discover new drug targets and inhibitors against S. aureus.

Methods:

This study consists of two major sections. In the upstream evaluation, after a comprehensive coreproteome
analysis, essential cytoplasmic proteins with no similarity to the human proteome were selected. Then the
S. aureus metabolome-specific proteins were selected, and novel drug targets were identified using the DrugBank
database. In the downstream analysis, a structure-based virtual screening approach was performed to reveal potential
hit compounds against adenine N1 (m1A22)-tRNA methyltransferase (TrmK) using the StreptomeDB library
and AutoDock Vina software. The compounds with a binding affinity > -9 kcal/mol were analyzed based on ADMET
properties. Finally, the hit compounds were selected based on Lipinski’s rule of five (RO5).

Results:

Three proteins, including glycine glycosyltransferase (FemA), TrmK, and heptaprenyl pyrophosphate
synthase subunit A (HepS1), were selected as feasible and promising drug targets based on PDB file availability
and their essential role in the survival of the S. aureus. Finally, seven hit compounds, including Nocardioazine_
A, Geninthiocin_D, Citreamicin_delta, Quinaldopeptin, Rachelmycin, Di-AFN_A1 and Naphthomycin_
K were introduced against the binding cavity of TrmK, as a feasible drug target.

Conclusion:

The results of this study provided three feasible drug targets against S. aureus. In the following,
seven hit compounds were introduced as potential inhibitors of TrmK, and Geninthiocin_D was identified as
the most desirable agent. However, in vivo and in vitro investigations are needed to confirm the inhibitory effect
of these agents on S. aureus.
Impact of Cannabinoid Receptors in the Design of Therapeutic Agents
against Human Ailments
Authors: Kumar Ankush , Gupta Ojasvi , Bhatia Rohit , Monga VikramDeep
Published: May 2023

The cannabinoid (CB) signalling cascade is widely located in the human body and is as-sociated with several pathophysiological processes. The endocannabinoid system comprises canna-binoid receptors CB1 and CB2, which belong to G-protein coupled receptors (GPCRs). CB1 recep-tors are primarily located on nerve terminals, prohibiting neurotransmitter release, whereas CB2 are present predominantly on immune cells, causing cytokine release. The activation of CB system con-tributes to the development of several diseases which might have lethal consequences, such as CNS disorders, cancer, obesity, and psychotic disorders on human health. Clinical evidence revealed that CB1 receptors are associated with CNS ailments such as Alzheimer’s disease, Huntington’s disease, and multiple sclerosis, whereas CB2 receptors are primarily connected with immune disorders, pain, inflammation, etc. Therefore, cannabinoid receptors have been proved to be promising targets in therapeutics and drug discovery. Experimental and clinical outcomes have disclosed the success sto-ry of CB antagonists, and several research groups have framed newer compounds with the binding potential to these receptors. In the presented review, we have summarized variously reported heter-ocycles with CB receptor agonistic/antagonistic properties against CNS disorders, cancer, obesity, and other complications. The structural activity relationship aspects have been keenly described along with enzymatic assay data. The specific outcomes of molecular docking studies have also been highlighted to get insights into the binding patterns of the molecules to CB receptors.
Exploring the Bioactivity of Soil Streptomyces sp. BACSAS14: An In Vitro
and In Silico Approach
Authors: Agarwal Sonal , Vivekanandan Swathika , Mooventhan Hemalatha , Vaithilingam Mohanasrinivasan , Chandrasekaran Subathra Devi
Published: May 2023

Background:

Discovery of novel anti-cancer drugs from natural origin has increased
tremendously due to the resistance of multiple chemotherapeutic drugs in breast cancer therapy and
its high toxicity to undesirable side effects.

Objective:

The aim of the study was to investigate the bioactivity of secondary metabolites derived
from Actinobacteria sp. BACSAS14 isolated from a vegetable farm in Vellore, Tamil Nadu, and
India.

Methods:

Five actinomycetes strains were isolated and screened for antagonistic activity by the
agar well diffusion method. Out of which, Actinobacteria sp. BACSAS14 exhibited potency, and
its crude extract was tested for anti-inflammatory, anti-microbial, anti-cancer, and antioxidant potential.
The Actinobacteria sp. BACSAS14 ethyl acetate extract was analyzed by Gas chromatography-
mass spectrometry, Fourier-transform infrared spectroscopy, and Thin Layer Chromatography
to determine the bioactive compounds. A drug interaction study with the anti-inflammatory
protein COX-2, anti-oxidant protein lipoxygenase, and anti-cancer protein MT1-MMP was done by
molecular docking analysis.

Results:

Maximum activity was found against Pseudomonas aeruginosa (19 mm) at a concentration
of 500 μL. Maximum inhibitory activity was 98.8±0.98 % at a concentration of 5 mg/mL with
an IC50 value of 417.58 μg/mL. Maximum antioxidant activity was 67.87 ± 0.59% at a concentration
of 5 mg/mL. At an extract concentration of 500 μg/mL, cell viability was found to be 31.62 ±
0.79 with an IC50 value of 365.23 μg/mL. The compound with the lowest binding energy was observed
to be sulfurous acid, cyclohexylmethyl isohexyl ester. In-silico studies of sulfurous acid,
cyclohexylmethyl isohexyl ester revealed promising anti-inflammatory, anti-oxidant and anticancer
potential.

Conclusion:

The current study reported that the bioactive secondary metabolites of Actinobacteria
sp. BACSAS14 retains anti-inflammatory, anti-cancer, and antioxidant properties. This is the first
report stating the production of the metabolite sulfurous acid, cyclohexylmethyl isohexyl ester from
Actinobacteria sp. BACSAS14.
Identification of miRNA-mRNA Regulatory Networks Associated with
Diabetic Retinopathy using Bioinformatics Analysis
Authors: Xu Weihai , Liang Ya , Zhuang Ying , Yuan Zhilan
Published: May 2023

Introduction:

Diabetic retinopathy (DR) is a major complication of diabetes and a lead-ing cause of visual loss. This study aimed to explore biomarkers for DR that may provide additional reference to DR pathogenesis and development.

Methods:

The differentially expressed genes (DEGs) between the DR and control samples in the GSE53257 dataset were identified. Logistics analyses were performed to identify DR-associated miRNAs and genes, and correlation analysis was performed to determine the correlation between them in GSE160306.

Results:

A total of 114 DEGs in DR were identified in GSE53257. Three genes, including ATP5A1 (down), DAUFV2 (down), and OXA1L (down), were differentially expressed between DR and con-trol samples in GSE160306. Univariate logistics analysis identified that ATP5A1 (OR=0.007, p=1.40E-02), NDUFV2 (OR=0.003, p=6.40E-03), and OXA1L (OR=0.093, p=3.08E-02) were DR-associated genes. ATP5A1 and OXA1L were regulated by multiple miRNAs, of which hsa-let-7b-5p (OR=26.071, p=4.40E-03) and hsa-miR-31-5p (OR=4.188, p=5.09E-02) were related to DR. ATP5A1 and OXA1L were closely correlated with each other in DR.

Conclusion:

The hsa-miR-31-5p-ATP5A1 and hsa-let-7b-5p-OXA1L axes might play novel and important roles in the pathogenesis and development of DR.
Matrix Inverse-based Highly Payload Novel Approach for Covert Transmission
Authors: Saini Ravi , Joshi Kamaldeep , Nandal Rainu , Yadav Rajkumar , Kumari Deepika
Published: May 2023

Background:

The necessity for data security is demanding in the digital age. The main
technique for achieving data security is Steganography. The technique of camouflaging the secret
object behind another cover object is known as Steganography. A novel, robust, high payload, and
imperceptible image steganography approach using matrix inverse in the spatial domain are proposed
in this manuscript. The basic idea is to devise a robust novel approach against various image
processing attacks, like cropping, compression, filters, and noise.

Objectives:

The study's objective is to develop a novel data-hiding approach that increases imperceptibility
and payload capacity and is robust against various image processing attacks, like filters,
compression, cropping, and noise.

Methods:

The matrix inverse procedure is used for the insertion and extraction of data. The symmetry
feature of the matrix inverse makes the task of insertion of data simple and efficient. It also
increases the hiding capacity while maintaining a finer level of imperceptibility and robustness.
MATLAB is used for the implementation of the new technique and results analysis.

Results:

The proposed method's robustness has been analyzed against image processing assaults
such as the inclusion of various noises, cropping, a variety of filters, and compression assaults.
The imperceptibility of the approach has been tested successfully using PSNR, BER, and NCC
metrics. The proposed method has been compared with the other two techniques. The experimental
and comparison results depict that the proposed approach provides high hiding capacity,
finer robustness, and imperceptibility.

Conclusion:

A novel, robust and imperceptible approach has been developed in this manuscript.
The proposed method has been compared with the methods developed by Jung & Yoo and Joshi
& Gill. The experimental findings show that the proposed technique offers better resilience, payload
capacity, and finer imperceptibility.
A Comparative Study on Approval of Follow-on Version of Sevelamer
Carbonate and Glatiramer Acetate (GA) in US, EU
Authors: Sankhwar Nisha , Shukla Vikesh Kumar
Published: May 2023

Many non-biological drugs, different in terms of their structure and mode of action,
pharmacological classification, and therapeutic indication, have a common factor of structural
complexity and are grouped as non-biological complex drugs (NBCDs). When an innovator drug
nears the time of off-patent, different manufacturers attempt to produce its subsequent version, so
the patients will have a cost-effective therapeutic equivalent. Since the innovator molecule is complex,
its follow-on drug can be called its true generic version, if its bioavailability, bioequivalence
and therapeutic equivalence to the innovator drug are demonstrated. However, it is observed that a
case-to-case basis approach is implemented by European Medicines Agency (EMA) and Food and
Drug Administration, US (USFDA) in the approval of such drugs and there is no uniformity observed
between the two.

:

In this study, an attempt is made to study the complexity of molecules compare and understand the
data requirements, and procedures adopted for the review and approval of such complex products.
Therefore, drug sevelamer carbonate and glatiramer acetate are selected for the study. A methodical
approach was followed. European assessment reports and drug approvals available in the orange
book database of the former two regulatory agencies were studied. It is observed that the generic
version of glatiramer acetate is approved as an abbreviated new drug application (ANDA) by
Food and Drug Administration whereas the same was approved as the hybrid application by European
Medicines Agency requiring the applicant to generate and submit more data. Thus, harmonization
of the regulatory requirements for the approval of follow-on versions of such complex drugs
is essential for better understanding, predictability of the regulatory process, and acceleration of the
drug approval process, in the interest of patients. This will help the faster access of the drugs to the
patients and allow interchangeability of the innovator drugs with its cost-effective generic version.
effect of knowledge management on work achievement PT. MDA Travel Manado
Authors: Malalantang Drevy Dallesandry
Published: May 2023

This study used a survey method by conducting research on Travel staff of MDA Travel Manado. The method of describing, analyzing and explaining the relationship between each variable. The proof was done statistically using SPSS 24.00 00 where the results obtained were Y = 63.756 + 0.361x. This means that each increase of one score or the addition of numbers in variable X, namely Knowledge Management, will have an effect on variable Y, namely Work Performance of 0.361x. The result of the correlation coefficient is 0.448, meaning that variable X (Knowledge Management) has a significant correlation with variable Y (Job Performance). The determinant coefficient is 0.201. It can be concluded that Knowledge Management has an effect of 20.0% on MDA Travel Manado's Travel staff Work Performance, while 80% is influenced by other variables. Through calculations for hypothesis testing based on tcount> ttable value where 3.179?2.021. This means that H0 is rejected and h1 is accepted, or in other words it proves that variable X or Knowledge Management affects variable Y or MDA Travel Manado Travel Staff Job Performance.
DEHUMIDIFIER DRYING OF SEAGRASS SIMPLICIA AT LOW TEMPERATURE FOR ANTIOXIDANT AND PHENOLIC PRESERVATION
Authors: Susilo Bambang , Jabbar Filayati Mukhammad Abdul , Bagus Hermanto Mochamad , Damayanti Retno , Akbar Yurisdanto Adamas , Rohim Abd.
Published: May 2023

Syringodium isoetifollium is seagrass a marine plant which is mostly found in Indonesian sea waters. Phenol is a kind of sensitive heat compound which will damage at high temperatures. This research aimed to study the effect of temperature using a dehumidified drying machine on the quantity of phenol content and testing of this antioxidant activity and the evaluation of drying characteristics of seagrasses such as decrease of moisture content, the distribution of temperature drying relative humidity, and energy consumption. In this research, the independent variaable were tempeartures (30 °C, 40 °C, and 50 °C) and the independent variable were the content of phenol and antioxidant activity of the seagrasses. The phenol content of each extract was measured with a microplate reader using a Follin-Ciocalteu reagent. The antioxidant activity was measured with the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. The result showed that the highest content of phenolic compounds (80.42766 ± 0.409a) and antioxidant activity (88.4185 ± 32.0709a) was found in the dehumidified dryer at a temperature of 40 °C. There were significant differences between temperatures of 30 °C and 50 °C. Dehumidifier drying at 30 °C, 40 °C, and 50 °C required 13 hours, 12 hours, and 7.5 hours to reach the final moisture content of seagrass 18-20% from the initial moisture content of 89.4% ± 0.04% (wb). The total phenol content and antioxidant activity with a temperature treatment of 40 °C dehumidifier drying machine showed the best results compared to temperatures of 30 °C, 50 °C, and oven at 40 °C. Based on the same temperature treatment, dehumidifier drying requires a faster time (12 hours) than oven drying (17 hours). The appropriate temperature and time of drying can produce the optimal total phenol and antioxidant activity.
Genocide in Kashmir: Right of Self-Determination, UNSC Resolutions and Holding India To Account Under International Humanitarian Law
Authors: Akthar Zia
Published: May 2023

Kashmir has been a flashpoint of conflict since independence from British rule in 1947 and the partition of India into two states. These two countries, India, and Pakistan, have both claimed the land on the northern most sector of the Subcontinent the focal point of which is the Valley of Kashmir. The conflict is not a domestic dispute or a regional issue between the two protagonists but engages international law because of the human rights violations and the atrocities committed that has engaged international humanitarian law.  The occupation by India of Kashmir was controversial from the start as it went against the aspirations of the population who had close affinity and kinship with Pakistan. The United Nations Security Council mandated a referendum to decide the future of the territory divided by a Line of Control, a military boundary, but India has refused to implement the resolutions. The Indian army has cracked down on the population under the Special Powers Act 1958 and various other opaque ordinances that oppress the population. The final act in this de facto occupation was transformed into de jure control by the Indian Parliament when it revoked Article 370 and Article 35 of the Constitution and annexed Kashmir. The Valley has been placed under lockdown and the population disfranchised with all political activity banned and demographic changes underway by a government appointed by India. The pogroms committed by the Security forces and the gross abuses of human rights have been catalogued in two UN Human Rights Council reports that implicate the Indian forces. The argument of this paper is that there should be rigorous application of international law and war crimes tribunals should be invested to prosecute the Indian officials for breaches of human rights established in the conduct of non-international conflicts (NIC).
Caracterización de actores en la minería del oro en Buriticá y el Bajo Cauca antioqueño
Authors: Bonilla-Calle Daniel
Published: May 2023

La explotación aurífera en Antioquia no solo ha incentivado la circulación de capital, sino el establecimiento de un orden social propio. Este artículo caracteriza las prácticas e interacciones de los distintos actores involucrados en la minería del oro en el municipio de Buriticá y la subregión del Bajo Cauca antioqueño entre 2016 y 2022. La metodología utilizada para el desarrollo de la investigación fue una combinación de técnicas cualitativas que incluyó la observación de campo, más de setenta entrevistas a profundidad y la consulta de múltiples fuentes documentales. Uno de los principales hallazgos es que agentes estatales y grupos criminales actúan en connivencia para el recaudo de rentas, no solo de la minería, sino de otras fuentes de financiación estatal y productivas, lo que impacta desfavorablemente a las comunidades locales.
Improving Mathematical Critical Thinking Ability Through Realistic Mathematics Learning In JHS Students
Authors: Sutarni Sri , Gatiniggsih Rustiwi
Published: May 2023

Critical thinking is a structured way of thinking in making decisions and solving problems. Because the critical thinking ability in junior high school students is low, realistic mathematics learning is considered to be able to improve students' critical thinking ability. The purpose of the research in this article is to describe the improvement of mathematical critical thinking ability through realistic mathematics learning reviewed from indicators and the averages increase each cycle. This type of research is Class Action Research that is carried out in 2 cycle. The research subjects consisted of mathematics teachers and 16 students of class VIII Muhammadiyah 5 Junior High School Surakarta. The data analysis technique in this study is qualitative descriptive to identify students and teachers during the mathematics learning process. The results of student work, data analysis are done by giving a score on each indicator. Score 1 if correct and score 0 if wrong. The results showed that the application of realistic mathematics learning improving the ability to think critically of mathematics. The average increase in mathematical critical thinking ability is 23.75% in pre-cycle, 71.25% in cycle I, and 85% in cycle II.
Development of trigonometry module based on PBL that oriented to high school students' concept of understanding
Authors: Bazuri Ahmad , Arliani Elly
Published: May 2023

This study aims to produce a problem-based learning module on trigonometry oriented towards the ability to understand concepts for grade X high school students and to describe the quality of the validity, practicality, and effectiveness of the module. This is a research and development with the ADDIE model, which includes five stages: analysis, design, development, implementation, and evaluation. The implementation of product development was conducted at the State Senior High School 1 Magelang, involving 36 students from class X MIPA 2. This research resulted in a trigonometry module based on problem-based learning syntax. The module is declared valid with an average assessment of experts' content of 4.24 (valid) and media experts of 4.45 (valid). The module was said to be practical, with the average student response questionnaire result of 3.93 (sufficient), the teacher's response questionnaire of 4.00 (practical), and the percentage of learning implementation of 95.24. With Minimum Completeness Criteria of 70, the module is declared effective with an average score of 80.72 for students' concept understanding, which is high, and the percentage of completeness is 87.88, which is good. Based upon the hypothesis test with a significance level of 0.05, it shows that the average understanding of students' concepts is more than 70.
How do mathematics teachers design tasks to assess students’ creative thinking ability?
Authors: Wijayanti Pradnyo , Siswono Tatag Yuli Eko , Juniati Dwi , Abadi Abadi , Hartono Sugi
Published: May 2023

This study aims to describe teachers' understanding of designing mathematical tasks to assess students' creative thinking abilities. The descriptive study involved 23 mathematics teachers in a city in East Java, Indonesia. The research Instrument is a task that reveals teachers' understanding of the notion of creative thinking, mathematics' problem of assessing students' creative thinking, some criteria to assess students' creative thinking, and examples of questions designed by the teacher. Data were analyzed descriptive-quantitatively and qualitatively with an iterative method consisting of data condensation, data display, and data verification. The study results indicate that teachers' understanding of creative thinking is still lacking, how to assess, and assessment criteria, their abilities still need to be improved
Effects of the WeChat mini program-based positive psychology intervention on psychological and health behavior motivation outcomes in patients with coronary heart disease (Preprint)
Authors: yang fang , liu jinxu , lei shanyan
Published: May 2023

BACKGROUND

Psychological problems are highly prevalent among patients with coronary heart disease and cause poor health behavior. WeChat mini program-based positive psychology intervention may improve psychological problems and health behavior.

OBJECTIVE

The purpose of this study was to preliminarily assess the feasibility and acceptability of the WeChat mini program-based positive psychology intervention and its efficacy on psychological and health behavior motivation outcomes in patients with coronary heart disease compared with a control group.

METHODS

Participants with coronary heart disease in the experimental group completed weekly positive psychology exercises delivered through the WeChat mini program for 6 weeks, while those in the control group received routine health education. Feasibility and acceptability were firstly evaluated of this study in a pilot study that recruited some participants in the experimental group. The Chinese version of Index of Well-being scale and Positive and Negative Affect Scale were used to assess the effect of the intervention on psychological outcomes and the Treatment Self-Regulation Questionnaire were used to assess the effect of the intervention on health behavior motivation outcomes.

RESULTS

Twenty-eight participants completed all the exercises during the intervention period. Compared to the control condition, the WeChat mini program-based positive psychology intervention improved the subjective well-being (t=-2.755, P=0.008), positive affect (t=-2.489, P=0.013), no-smoking motivation (t=-2.051, P=0.045), regular exercise motivation (Z=-2.410, P=0.016), and healthy diet motivation (Z=-2.007, P=0.045) of the patients with coronary heart disease and reduced their negative affect (t=2.338, P=0.023).

CONCLUSIONS

These preliminary findings showed that the WeChat mini program-based positive psychology intervention was feasible, acceptable, and associated with improvements in subjective well-being, affect, and health behavior motivation. Larger randomized controlled trials are needed to examine this intervention’s impact on health behavior adherence and other important outcomes.

CLINICALTRIAL

This study is registering with ClinicalTrials.gov.
CEO Type and Earnings Management to Avoid Loss or Earnings Decreases: Evidence from South Korea
Authors: Na Kyunga , Lee Yun-jeong , Yu Hagyeong
Published: May 2023

This study examines the relations between the CEO type (owner CEO vs. professional CEO) and earnings management over 9,266 firm-years from 2011 to 2020 in Korea. Two earnings management measures, accrual management and real activity management (abnormal cash flow from operations, abnormal production cost, and abnormal discretionary expense), are considered as means to avoid reporting losses or earnings decreases. We partition the sample into two groups based on the type of CEO (owner CEO vs. professional CEO) and investigate whether earnings management is used for achieving earnings targets (small profit or small earnings increases) for each group. We find all earnings management measures are significant at the 5% level or better in the direction of aggressive earnings management in the owner CEO sample, while all but one measure (abnormal production cost) are insignificant in the professional CEO sample. Our findings suggest that an owner CEO is more likely to manage earnings to achieve small profit or small earnings increases compared to a professional CEO.
Text To Speech with Custom Voice
Authors: Poojary Nigam R , Ashish K H
Published: May 2023

Abstract: The Text to Speech with Custom Voice system described in this work has vast applicability in numerous industries, including entertainment, education, and accessibility. The proposed text-to-speech (TTS) system is capable of generating speech audio in custom voices, even those not included in the training data. The system comprises a speaker encoder, a synthesizer, and a WaveRNN vocoder. Multiple speakers from a dataset of clean speech without transcripts are used to train the speaker encoder for a speaker verification process. The reference speech of the target speaker is used to create a fixed-dimensional embedding vector. Using the speaker embedding, the synthesizer network based on Tacotron2 creates a mel spectrogram from text, and the WaveRNN vocoder transforms the mel spectrogram into time-domain waveform samples. These waveform samples are converted to audio, which is the output of our work. The adaptable modular design enables external users to quickly integrate the Text to Speech with Custom Voice system into their products. Additionally, users can edit specific modules and pipeline phases in this work without changing the source code. To achieve the best performance, the speaker encoder, synthesizer, and vocoder must be trained on a variety of speaker datasets.