bluuebunny/crossref_metadata_2025 huggingface dataset:
Innovation in the Philosophy of Education
Authors: Azam Begmatov , Yurievich Lozovoy Alexey
Published: May 2022

Abstract: The further development of civilization on the planet increasingly needs new ideas of preserving peace, coherence, mutual understanding and mutual support between peoples and government. New ideas are always the result of education. This task, in our opinion, will mainly be able to solve the scientifically based, practically directions of the new world education system. In this article we will try to talk about some new ideas that can form the basis of a new philosophy of education. Our goal is to introduce the reader for the first time to the idea of functional value analysis (FVA) to various phenomena, processes, objects and states of reality. Keywords: functional value analysis, hypothesis, philosophy of education, functions, education system.
Interventional surgery effectiveness in treatment of the cervical spine and shoulder joint chronic pain
Authors: Abakirov Medetbek D. , Chmutin Gennady E. , Al-Bawareed Omar A. , Panin Mikhail A. , Alenizi Abdel Rahman A. , Petrosyan Armenak S. , Aldin Mutaz Alm , Mayer Adam R.
Published: May 2022

Relevance. Degenerative diseases of the spine are among the most common pathologies that cause significant medical, social and economic losses. Thus, a retrospective analysis of the Humana database from 2008 to 2014 indicates a sharp increase in discogenic neurocompression lesions of the cervical spine, which is 42 %. Degenerative processes are characterized by metabolic and structural changes in the intervertebral discs (IVD), which lead to the loss of its properties. The aim of the study was to analyze the results of intervertebral disc nucleoplasty and radiofrequency denervation of the facet joints in patients with cervical joint hernias. Materials and Methods . Intervertebral disc nucleoplasty and radiofrequency denervation of the facet joints in patients with hernias of the cervical spine was performed in 55 patients aged 18 to 74 years (mean age 36.28 ± 2.19 years), of which 56.36 % (31 patients) were men and 43.64 % (24 people) were women. Results and Discussion. The results demonstrate a significant improvement (p0.001) in VAS and ODI in patients after treatment. The majority of patients (45.45 %) rated their health status as “good”, 41.82 % of respondents believe that after the intervention, their health status can be assessed as “excellent”. Only 3 patients (5.45 %) indicated an unsatisfactory condition, which may be due to individual psychological characteristics, comorbidities, or a reduced sensitivity threshold. Conclusion. Nucleoplasty of the intervertebral disc and radiofrequency denervation of the facet joints is an effective and safe method for the treatment of intervertebral hernias of the cervical spine.
Beck’s smallnodular sarcoid in dermatologist practice
Authors: Mesnyankina Olga A. , Ryabov Sergey K.
Published: May 2022

The low incidence of skin sarcoidosis in the practice of a dermatologist, numerous clinical manifestations, similarities with other dermatoses cause difficulties in timely diagnosis, lead to diagnostic errors, and, as a consequence, untimely therapy. The presented clinical observation demonstrates the important role of conducting a detailed differential diagnostic search in patients with suspected skin sarcoidosis. Cutaneous manifestations of the pathological process can be combined with lesions of the lymph nodes, respiratory system and other organs, precede them or be isolated, in this regard, each patient with a verified diagnosis of skin sarcoidosis should be examined to exclude systemic signs of the disease. It should be emphasized that sarcoidosis of the skin can have a paraneoplastic character, being a marker of lymphoproliferative processes, myelodysplastic syndrome, therefore, correct and timely verification of the skin process may be a prerequisite for early diagnosis of other, possibly subclinically occurring pathological processes in the patient.
Enhancing EFL students’ reading learning process in COVID-19 pandemic through Nearpod
Authors: Pupah Emmas Mas , Sholihah Umi
Published: May 2022

This research aims to enhance students’ reading learning process using a genre-based approach during the COVID-19 pandemic through Nearpod. Action research with four stages was applied as a research design. The qualitative data were collected through interviews and teacher’s field notes, while the quantitative data were obtained by students’ reading pre-test and post-test. The qualitative data were analyzed by assembling the data, coding the data, building interpretations, and reporting the outcomes. Meanwhile, the quantitative data were analyzed using descriptive quantitative analysis. Findings demonstrated that students learned how to determine the main idea, make an inference, and distinguish detailed information from the texts. They also considered Nearpod as an accommodating and encouraging tool in learning. The teacher addressed how to reinforce the students’ reading learning process by deep consideration, preparation, and reflection to ensure that Nearpod worked properly. The statistical report of students’ scores for the pre-test and post-test showed improvement from 64.7 to 84.8. The average students’ post-test score was greater than the pre-test. This study revealed that the Nearpod program successfully supported the reading learning process for students because of its user-friendliness and it enabled teachers to monitor students’ progress during the teaching process.
Konsep Mahabbah dalam Al-Qur’an
Authors: Zuherni Zuherni , Ilyas Raudhatul Jannah
Published: May 2022

Human love is nature from God. Mahabbah or love for fellow human beings in the form of love for parents, children, husband and wife and relatives is something that is natural, because of closeness and other emotional relationships. Moreover, love for them is based on love for Allah swt. However, all of this is forbidden if love for those closest to him turns him away from Allah, making him close his eyes in distinguishing between right and wrong. On the basis of this thought, it is necessary to study how to place the love of fellow human beings in accordance with the instructions of the Qur'an. The results of this paper indicate that love for fellow human beings both for parents, children, husband and wife and relatives in Islam is highly recommended, but if this love makes someone associate partners with Allah, commit immorality and disobey the Messenger of Allah, then love for fellow humans is not justified. Rasa cinta yang dimiliki manusia merupakan suatu fitrah dari Allah. Maḥabbah atau cinta sesama manusia berupa cinta kepada orang tua, anak, suami istri dan sanak saudara sesuatu yang alami, karena kedekatan dan hubungan emosional lainnya. Apalagi cinta kepada mereka didasari pada cinta kepada Allah swt. Akan tetapi, semua itu dilarang jika dengan cinta kepada orang-orang terdekat membuatnya berpaling dari Allah, membuat mata dia tertutup dalam membedakan antara yang benar dan yang salah. Atas dasar pemikiran inilah perlu dikaji bagaimana menempatkan cinta sesama manusia yang sesuai dengan petunjuk al-Qur’an. Hasil penulisan ini menunjukkan bahwa cinta sesama manusia baik kepada orang tua, anak, suami istri maupun sanak saudara di dalam Islam sangat dianjurkan, namun apabila cinta ini membuat seseorang menyekutukan Alah, berbuat maksiat serta ingkar kepada Rasulullah, maka rasa cinta kepada sesama manusia tidak dibenarkan.
Una aproximación teórica a la dominación simbólica a partir del Corpus Christi colonial cuzqueño (Siglo XVII)
Authors: Fiorani Agustina , Franco Francisco
Published: May 2022

El presente artículo pretende llevar a cabo una reconstrucción teórica de la dominación simbólica de la Corona española en los Andes Centrales. Consideraremos para ello cómo se presenta la imposición discursiva/simbólica española en la fiesta de Corpus Christi en Cuzco, entendiendo que en la misma se entrelaza una mixtura de elementos hispánicos y andinos de larga data, construidos, reconstruidos y reproducidos a través de la agencia de cada grupo participante en el festejo.
A importância do streaming para o documentário durante a pandemia da Covid-19: uma conversa com o cineasta Cristiano Burlan
Authors: Lemos Jr Urbano , Gosciola Vicente
Published: May 2022

A produção e a distribuição audiovisual foram seriamente comprometidas durante o período de isolamento decorrente das políticas de distanciamento social por causa da Covid-19. Com as salas de cinema fechadas, diversos realizadores tiveram que se adaptar e encontraram nas plataformas de transmissão a possibilidade de projetarem seus trabalhos. O streaming, que já se colocava como uma realidade para o cinema, assumiu protagonismo mostrando-se como uma alternativa com acesso gratuito; e distribuição mais democrática. A entrevista a seguir aponta para a importância do documentário no período da Covid-19 que encontrou no digital a sua permanência de representação do mundo em que vivemos. A conversa com o cineasta Cristiano Burlan traz os desafios em divulgar os filmes durante o período pandêmico e as possibilidades que os realizadores encontraram para que seus filmes fossem vistos e debatidos. Durante a entrevista, Burlan falou sobre a trilogia do luto, feminicídio e problemas sociais, temas bastante presentes nos seus filmes. Segundo o cineasta, por mais que haja uma motivação pessoal, o processo de criação se efetiva no encontro com o outro.
A (des)patologização de Jair Bolsonaro nas redes em tempos de pandemia de Covid-19 no Brasil
Authors: Borges Wilson Couto , Franklin Camila Fortes Monte
Published: May 2022

O presente artigo é parte de uma pesquisa maior e tem como objetivo identificar as estratégias narrativas e intenções textuais, como também a produção de sentidos sobre o processo de patologização e despatologização em torno de ações do presidente da República Jair Messias Bolsonaro nas redes sociais. Em tempos de pandemia de Covid-19 no Brasil, a partir de recortes temporais diferentes, é possível encontrar conexões entre tempos históricos distintos, que atualizam formas de se compreender os fenômenos sociais. Utilizando a Narratologia como abordagem teórico-metodológica, esse trabalho busca perceber a formação de processos simbólicos em postagens do Instagram que associam o presidente da República à loucura e a insanidade, produzindo sentidos que constroem efeitos de real.
Imprensa e Rádio no Bicentenário da Independência: O Discurso Jornalístico sobre o Rádio como Mídia Educativa e Cultural em Contexto Pandêmico na Bahia
Authors: Medeiros Magno , Souza Andrade Pricilla
Published: May 2022

O objetivo do artigo é propor uma investigação descritiva e analítica dos casos de utilização do rádio como mídia educativa no contexto da atual pandemia no estado da Bahia em duas matérias jornalísticas veiculadas pelos jornais O Correio da Bahia e A Tarde. Para isso, acredita-se que é imprescindível apontar a importância da imprensa escrita e do rádio no que se refere à história, memória e identidades que esses veículos suscitam ao atravessarem o Bicentenário da Independência do Brasil, enquanto experiência; a vida do povo brasileiro, e, no caso deste trabalho, especialmente dos baianos. No período pandêmico, surgiram relatos impressos de algumas experiências da utilização do rádio na região nordeste e, neste estudo, duas matérias extraídas dos dois jornais principais da capital baiana são analisadas. Elas suscitaram discussões relevantes acerca dos discursos sobre a efetiva participação do rádio, nos imaginários e identidades culturais e sociais, políticas e econômicas da população. O objetivo geral desse estudo é relacionar imaginários e identidade do bicentenário da Independência, com o surgimento da imprensa no Brasil. Posteriormente como este meio dialoga com o surgimento e papel do rádio no Brasil, observando como se apresentam os discursos que relatam as ações educativas com a utilização do rádio. Metodologicamente, são analisados trechos do discurso em duas matérias de Jornais que tratam da utilização ou reinvenção do rádio neste período pandêmico, sob a ótica de uma abordagem qualitativa, descritiva e analítica. Utiliza-se instrumentos da Análise do Discurso de linha francesa fundamentados pelos estudos que refletem história e memória.
Variability in venous gas emboli following the same dive at 3,658 meters
Authors:   Univ at Buffalo, Dept of Exercise and Nutrition Sciences, Center for Research and Education in Special Environments, Buffalo, New York U.S., Hess Hayden W. , Wheelock Courtney E. ,   Univ at Buffalo, Dept of Exercise and Nutrition Sciences, Center for Research and Education in Special Environments, Buffalo, New York U.S., St. James Erika ,   Univ at Buffalo, Dept of Exercise and Nutrition Sciences, Center for Research and Education in Special Environments, Buffalo, New York U.S.,   Univ at Buffalo, Dept of Emergency Medicine, Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York U.S., Stooks Jocelyn L. ,   Univ at Buffalo, Dept of Exercise and Nutrition Sciences, Center for Research and Education in Special Environments, Buffalo, New York U.S., Clemency Brian M. ,   Univ at Buffalo, Dept of Exercise and Nutrition Sciences, Center for Research and Education in Special Environments, Buffalo, New York U.S.,   Univ at Buffalo, Dept of Emergency Medicine, Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York U.S., Hostler David ,   Univ at Buffalo, Dept of Exercise and Nutrition Sciences, Center for Research and Education in Special Environments, Buffalo, New York U.S.,   Univ at Buffalo, Dept of Emergency Medicine, Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York U.S.
Published: May 2022

Update: originally posted in Vol 48 #2 Exposure to a reduction in ambient pressure such as in high-altitude climbing, flying in aircrafts, and decompression from underwater diving results in circulating vascular gas bubbles (i.e., venous gas emboli [VGE]). Incidence and severity of VGE, in part, can objectively quantify decompression stress and risk of decompression sickness (DCS) which is typically mitigated by adherence to decompression schedules. However, dives conducted at altitude challenge recommendations for decompression schedules which are limited to exposures of 10,000 feet in the U.S. Navy Diving Manual (Rev. 7). Therefore, in an ancillary analysis within a larger study, we assessed the evolution of VGE for two hours post-dive using echocardiography following simulated altitude dives at 12,000 feet. Ten divers completed two dives to 66 fsw (equivalent to 110 fsw at sea level by the cross correction method) for 30 minutes in a hyperbaric chamber. All dives were completed following a 60-minute exposure at 12,000 feet. Following the dive, the chamber was decompressed back to altitude for two hours. Echocardiograph measurements were performed every 20 minutes post-dive. Bubbles were counted and graded using the Germonpré and Eftedal and Brubakk method, respectively. No diver presented with symptoms of DCS following the dive or two hours post-dive at altitude. Despite inter- and intra-diver variability of VGE grade following the dives, the majority (11/20 dives) presented a peak VGE Grade 0, three VGE Grade 1, one VGE Grade 2, four VGE Grade 3, and one VGE Grade 4. Using the cross correction method for a 66-fsw dive at 12,000 feet of altitude resulted in a relatively low decompression stress and no cases of DCS.
Repetitive hyperbaric oxygen therapy for paroxysmal sympathetic hyperactivity after acute carbon monoxide poisoning
Authors:   Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Korea, Choi Sangchun , Kim Hyuk-Hoon ,   Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Korea, Beom Seong ,   Department of Emergency Medicine, Dankook University College of Medicine, Cheonan, Korea, Jung Yoon Seok ,   Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Korea
Published: May 2022

Delayed neuropsychological sequelae (DNS) are relatively common complications of acute carbon monoxide (CO)poisoning, and usually develop within several days to weeks after the initial clinical recovery from acute CO poisoning. DNS can consist of various symptoms such as memory loss, confusion, ataxia, seizures, urinary incontinence, fecal incontinence, emotional lability, disorientation, hallucinations, mutism, cortical blindness, psychosis, parkinsonism, gait disturbances, rigidity, bradykinesia, and other motor disturbances. Paroxysmal sympathetic hyperactivity (PSH) is a potentially life-threatening disease secondary to acute acquired brain injury. It is characterized by episodic and simultaneous paroxysmal increases in sympathetic and motor activities, not rare in patients with a severe traumatic brain injury. The term PSH is clinically more accurate than the previously used ones describing such conditions as non-stimulated tachycardia, hypertension, tachypnea, hyperthermia, external posturing, diaphoresis, and paroxysmal autonomic instability with dystonia. Development of PSH typically prolongs the length of hospital stay and potentially leads to a secondary brain injury or even death. To date, the occurrence of PSH in the DNS after acute CO poisoning has not been reported in the literature. Potential mechanisms underlying the development of DNS in the deep white matter of the brain are immune-related inflammation and vasodilatation. Repetitive hyperbaric oxygen therapy, combined with methylprednisolone administration, may inhibit DNS progression by inducing cerebral oxygenation, inhibiting inflammation, and reducing cerebral edema. Herein, we report three cases in which the patients recovered from the PSH as DNS after CO poisoning after receiving repetitive hyperbaric oxygen therapy.
Systematic Work with Speaking Skills and Motivation in Second Language Classes
Authors: Horverak May Olaug , Langeland Gerd Martina , Løvik Agnete , Askland Sigrunn , Scheffler Paweł , Wach Aleksandra
Published: May 2022

Learning a foreign language is more difficult for some students than others, and particularly speaking out loud in class may be a challenge. The aim of this study is to investigate the potential of a systematic approach to facilitate mastery, motivation and a supportive language learning environment, to limit foreign language anxiety. An intervention was carried out in different language learning contexts, including English classes in Norway and Poland and Spanish classes in Norway. The research material collected consists of student logs, student evaluations and self-reported data from a validated questionnaire on foreign language anxiety. The findings show that many students reported becoming more motivated and comfortable in class and that the method helped them work with strategies to overcome problems. Self-reported questionnaire data suggest that in two of three contexts, the foreign language anxiety level of the students decreased significantly during the intervention period. It may be difficult to generalise based on the findings presented here as the sample from each context is limited, the data is self-reported, the intervention period was limited and there is no control group. To strengthen the study’s findings, triangulation of multiple data sources was used. To conclude, the five-step method presented in this study may be a useful strategy to facilitate developing motivation and creating a supportive learning environment in the language classroom. However, more longitudinal and extensive studies are needed to investigate the potential of the approach presented here further.
The GoldList Notebook Method: A Study on L2 Vocabulary Learning
Authors: Duplice John
Published: May 2022

Vocabulary knowledge is of paramount importance when learning a second language. It requires effective and practical classroom vocabulary learning methods for long-term acquisition. Specific learning aspects helping the learner remember vocabulary such as spaced repetition and retrieval practice have shown efficacy but are often disconnected from practical in-class methods that can be used repeatedly. This study looked at data from 74 university students in Japan studying English vocabulary with the GoldList Notebook Method, which incorporates spaced learning and retrieval practice. The study was conducted over a nine-week period and consisted of a pre-test of target L2 idioms, a lesson teaching the idioms, the implementation of the GoldList Notebook Method, and a post-test on the target idioms. The data collected were analyzed through fixed effects with a generalized linear model in R version 4.0.3 and R Studio 1.2.5. In addition to quantitative data collected through the pre- and post-tests, qualitative observational data was compiled on the use of the GoldList Notebook Method in the classroom. The findings showed efficacy in using the method and found particular merit to spaced learning over two-week intervals. The study further addresses problems teachers may face implementing the method in the classroom and possible ways to alleviate the issues.
Facebook as a Flexible Ubiquitous Learning Space for Developing Speaking Skills
Authors: Mykytiuk Svitlana , Lysytska Olena , Melnikova Tetiana , Mykytiuk Serhii
Published: May 2022

he research studied the effectiveness of the integration of Facebook as a flexible ubiquitous learning space into the educational process for speaking skills development of undergraduate students learning English as a second language. For this purpose teaching was organised via a specially created and moderated Facebook group where various media resources, uploaded materials, links to different applications and other social networking opportunities were accumulated. It was designed to achieve the educational programme objectives and address the specifics of digital age learning. A set of specially designed materials posted on the Facebook platform for language input, structured output, and communicative output activities was applied in experimental teaching to develop talk as transition, talk as interaction and mediation, and talk as performance. The results of the quasi-experiment (students’ speaking performance) were assessed in the form of the post-test with the data being analysed and interpreted based on descriptive and inferential statistics (independent samples t-test) by means of SPSS. The results revealed higher achievement scores of the experimental group in comparison to the control group in terms of expanding vocabulary, increasing English grammar literacy, developing interactive skills, discourse management, and pronunciation. The survey administered to find out the learners’ impressions of the successfulness of the FB-assisted activities revealed their overall positive attitude to the new methodology and usefulness for the development of all speaking qualifications checked.
Reynold's equation in stochastic form for curved circular and rough porous flat plates accounting viscosity variation lubricated with conducting couple stress fluid and MHD
Authors: A Salma , N Hanumagowda B , K Sreekala C
Published: May 2022

A theoretical analysis of curved circular and rough porous flat plates
is studied for the case of conducting couple stress fluid accounting for
viscosity variation and MHD. By using Stochastic Reynold’s boundary
conditions, the equation for pressure distribution is derived. The
results reveal that viscosity variation, couple stress, roughness, MHD
increases the load carrying capacities and squeezing time while the
existence of a porous region decreases the above characteristics.
Resolution of severe cardiomyopathy after catheter ablation of an anteroseptal accessory pathway: A case report
Authors: Baqal Omar J. , Ladia Vatsal M. , Masry Hicham El
Published: May 2022

Background: In patients with non-sustained tachyarrhythmias,
left ventricular (LV) systolic dysfunction is uncommon. The role of
catheter ablation (CA) in asymptomatic patients with tachyarrhythmia
remains unclear. Case presentation: We report a 20-year-old
patient without sustained tachyarrhythmia with a left ventricular
ejection fraction of 20% who underwent radiofrequency catheter ablation
(RFCA) of anteroseptal accessory pathway. She achieved normalization of
left ventricular systolic function noted on echocardiography performed
at four weeks post-ablation. Conclusions: Our case highlights
significant improvement in LV systolic function after catheter ablation
of an “asymptomatic” ventricular preexcitation. Current guidelines do
not endorse ablating asymptomatic patients, but careful follow up with
serial echocardiograms might be warranted. Prophylactic ablation of
those patients with clear evidence of LV dyssynchrony or wide left
bundle branch pattern and persistent preexcitation is worth further
consideration.
Simultaneous profiling of oral and placenta microbiome in pregnant women with Preeclampsia: a cross-sectional study
Authors: Cooper Shontreal , Borgida Adam , Yuan Hanshu , Panier Hunter , Russell Jordan , Thacker Sejal , Hammer Erica , Hariharan Amirtha , Kuo Chia-ling , Blanck Nyle , Maas Kendra , Campbell Winston , Zhou Yanjiao
Published: May 2022

Objective: Preeclampsia (PE) is a leading cause of morbidity and
mortality in pregnancy. This observational study aims to determine
associations between oral and placental microbiome in women with and
without preeclampsia and periodontal disease (PD) and evaluate systemic
immune responses in patients with and without PE and PD. Population:
Fifty-four pregnant patients with and without PE and PD were recruited.
The microbiome profiles of both oral subgingival region and placenta
were characterized by V4 region of 16S rRNA gene sequencing. Systemic
inflammation markers tumor necrosis factor-alpha (TNF-α), C-reactive
protein (CRP), lipopolysaccharide binding protein (LBP), interleukins 6
& 8 (IL-6, IL-8) in blood were measured by ELISA. Results: PD
significantly increased the risk of PE after adjustments for age,
preterm delivery and smoking status (OR=2.26, 95% CI=1.14-4.48,
p=0.024). A group of oral associated bacteria Veilonella, Fusobacterium,
Haemophilus, Granulicatella, Streptococcus, Gemella and Neisseria in
placenta had significantly higher prevalence in women with PE compared
to women without PE (53.8% vs 19.0%, p=0.018), the highest prevalence
in patients with both PE and PD (58.8%). Relative abundances of
Haemophilus, Veillonella and Fusobacterium in oral samples were
significantly higher in patient with PE than those without PE.
Proinflammation cytokine analysis showed that PE patients with PD had
higher blood IL-8 levels than PE patients without PD (p=0.028).
Conclusion: Oral-like microbiome was identified in placenta more
frequently in patients with PE than those without PE. Placental
microbiome is associated with systemic inflammation. High abundances of
Haemophilus in oral cavity is associated with increased risk of PE.
Maternal Comorbidity and Adverse Perinatal Outcomes in Female Adolescent and Young Adult Cancer Survivors: a Cohort Study
Authors: Desai Milli , Zhou Beth , Nalawade Vinit , Gyamfi-Bannerman Cynthia , Veeravalli Nina , Henk Henry , Murphy James , Whitcomb Brian , Su H. Irene
Published: May 2022

Objectives: To evaluate risks of preterm birth and severe maternal
morbidity (SMM) in female adolescent and young adult cancer survivors;
assess maternal comorbidity as a potential mechanism; determine whether
associations differ by use of assisted reproductive technology (ART).
Design: Retrospective cohort Setting: Privately insured females in the
U.S. Sample: Female with live births from 2000 to 2019 within
OptumLabs®, a U.S. administrative health claims dataset Methods:
Log-binomial regression models estimated relative risks of preterm birth
and SMM by cancer status and tested for effect modification. Causal
mediation analysis based on a counterfactual approach evaluated the
proportions explained by maternal comorbidity. Main Outcome Measures:
SMM, preterm birth Results: Among 46,064 cancer survivors, 2,440
singleton births, 214 multiple births, and 2,590 linked newborns
occurred after cancer. In singleton births, preterm birth incidence was
14.8% in cancer survivors versus 12.4% in females without cancer (aRR
1.19, 95%CI 1.06-1.34); SMM incidence was 3.9% in cancer survivors
versus 2.4% in females without cancer (aRR 1.44, 95%CI 1.13-1.83).
Cancer survivors had more maternal comorbidities before and during
pregnancy; 26% of the association between cancer and preterm birth and
30% of the association between cancer and SMM was mediated by maternal
comorbidities. Associations between cancer and outcomes did not differ
between ART and non-ART births. Conclusion: Preterm birth and SMM risks
were modestly increased after cancer. Significant proportions of
elevated risks may be due to increased comorbidities. Prevention and
treatment of comorbidities provides an opportunity to improve perinatal
outcomes among cancer survivors.
Threatened species could be more vulnerable to climate change in tropical countries
Authors: Chowdhury Shawan
Published: May 2022

Insects are the most speciose group of animals and play a central role
in ecosystem processes and functioning, yet they are often overlooked in
conservation studies. Many studies have reported a dramatic decline of
insects globally, where climate change is considered a profound threat;
however, how climate change is impacting tropical insects is largely
unknown, given most studies are from the temperate region. Here, by
considering Bangladeshi butterflies as a case study, I developed
climatic suitability maps for 242 species and compared the suitability
under current and future (2081-2100) climatic conditions. Overall, the
projected future climate could impact 241 of 242 butterfly species
(except for Spindasis elima), where 42% species could experience range
contraction. Alarmingly, the impact could be significantly more severe
among threatened species. While the direction of shift in habitat
suitability could be multidimensional, about 65% of species might move
north. While the suitability range could expand for about 58%, most
threatened species (58%) could experience range contraction. The mean
elevation of the suitable habitat could increase by 238%, and again the
situation could be more severe for the threatened butterflies (from 42m
to 108m). The niche-overlap analysis indicates that about 54% of the
realised niche could be altered. Although there might be no significant
association between the shift in habitat suitability along the
elevational gradient, migratory species could experience a more
significant shift than non-migrants. I show that climate change could
have a severe impact on Bangladeshi butterflies – depending on
Socio-Economic Pathways (ssps), the future climatic condition could be
unsuitable for 2 (ssp126) – 34% (ssp585) species. To mitigate insect
decline globally, and therefore, to meet the Post 2020 Biodiversity
Framework targets, I urge immediate detection of climate change impact
on tropical insects and developing effective conservation strategies.
Heart-Type Fatty Acid Binding Protein for Early Diagnosis of Perioperative Myocardial Infarction After Off-pump Coronary Artery Bypass Graft Surgery: Diagnostic Value and Optimal Cut-off Point
Authors: Liu Zihou , Zhai Wenqian , Zhang Wei , Shi Yifei , Ma Xiaozhong , Chen Qingliang , Wang Qiang , Jiang Nan , Guo Zhigang , Liu Jianshi
Published: May 2022

Objectives: This study aimed to evaluate the early and rapid
diagnostic value and the cut-off value of Heart-type fatty acid-binding
protein (H-FABP) for the perioperative myocardial infarction (PMI)
diagnosis after off-pump coronary artery bypass grafting (OPCABG)
surgery. Method: 109 patients scheduled for first-time,
elective, and isolated OPCABG surgery were erolled in this
single-center, prospective and consecutive study. Serial samples for
measurement of H-FABP at pre-anesthesia induction (T0, baseline),
completion of last distal anastomosis (T1), on ICU admission (T2), and
at 2h (T3), 4h (T4), 8h (T5), 24h (T6), and 48h (T7) were taken to
analyze for H-FABP. CK-MB and cTnI were taken at T4, T5, T6, and T7.
Patients were first divided into three groups according to the level of
cTnI and ECG changes within the early 24 hours. Results: 44
patients served as a control group, 52 patients identified as myocardial
injury group, and 13 patients defined as myocardial infarction group.
The level of H-FABP released was significantly higher in the myocardial
infarction group than another two groups. Using a cut-off value of 20.53
ng/ml for H-FABP, the sensitivity was 84.62%, 92.31%, and 76.92%
immediately, 2 hours, and 4 hours after entering the ICU. The
sensitivity of combined H-FABP and cTnI was 92.31% and 84.62% at 4 and
8 hours after entering the ICU. Conclusions: With an optimal
H-FABP cut-off level of 20.53 ng/ml, H-FABP was the early and reliable
biomarker for PMI diagnosis after OPCABG.
Short Course Venetoclax with standard chemotherapy is effective in Early T cell precursor acute lymphoblastic leukemia
Authors: Borah Pronamee , Dayal Nitin , Pathak Sangeeta , Naithani Rahul
Published: May 2022

Early T cell precursor acute lymphoblastic leukemia is a relatively new,
high risk subgroup of acute lymphoblastic leukemia characterized by
unique immune-phenotype and disease biology. ETP ALL cells share
similarities with hematopoietic stem cells and myeloid progenitor cells.
These patients have lower rates of complete remission overall survival.
Venetoclax is an orally bioavailable BCL 2 inhibitor. We report the
treatment outcomes of 2 patients with ETP ALL who achieved MRD negative
remission with short course of venetoclax.
Human-tiger (Panthera tigris) conflict: status and trend in the Chitwan National Park, Nepal
Authors: Kandel Kshitiz , Sharma Chhatra Mani , Pokheral Chiranjibi
Published: May 2022

This study explores an understanding of human-wildlife conflict (HWC)
focused on tiger, particularly the status and trend of human-tiger
conflict (HTC), in three major areas of Chitwan National Park (CNP);
Ayodhyapuri, Patihani and Meghauli VDCs. A set of questionnaire survey
was conducted in 98 households [Ayodhyapuri (38), Patihani (30) and
Meghauli (30)]. Additionally, key informant interviews were conducted
and official records of CNP, National Trust for Nature Conservation
(NTNC) and Department of National Park and Wildlife Conservation (DNPWC)
during month of June- July, 2017 were referred. Records from 2003 to
2015 at CNP shows that highest HTC was recorded in the year 2003-2004
(235 cases), out of which human casualties were 22 (4 injured and 18
killed). The trend has declined thereafter with the lowest conflict
recorded in the year 2013-2014 (17 cases), out of which human casualties
were 6 (4 injured and 2 killed). A significantly higher human-tiger
interaction was recorded in Ayodhypuri compared to other two study sites
(χ2 = 7.88; d.f. = 2; p = 0.02). However, a contradictory trend was
obtained based on our survey owing to the long compensation procedure
(51.02%), less compensation (30.61%) and weak information flow
(18.36%). Besides, the development of dense community forest lured the
tigers to the nearby buffer zone causing conflicts with tigers.
Nevertheless, the perception of respondent relative to tiger
conservation was found to be positive. Conservation education, awareness
programs along with adequate and prompt compensation against damages
coupled with regular/timely monitoring of tigers may help to reduce
human-tiger conflicts. Keywords: Human-tiger conflict; Compensation;
Livestock depredation; Retaliation
Estudo de avaliabilidade do manual de diluição de medicamentos injetáveis de um hospital universitário
Authors: Souza Daiane , Chaves Sônia Cristina , Noblat Lúcia
Published: May 2022

Descreve-se a segunda etapa de Estudo de Avaliabilidade sobre o Manual de Diluição de Medicamento Injetáveis do Complexo HUPES. Após obtenção e validação do seu Modelo Teórico-Lógico (MTL) em etapa anterior, no estudo atual visou- -se avaliar preliminarmente o funcionamento do manual na prática, identificando-se áreas para sua melhoria; obter perguntas para avaliações completadas futuras; e emitir recomendações ao final do processo. Tratou-se de estudo de metodologia qualitativa realizado entre Fevereiro e Abril de 2020 no Complexo HUPES. Participaram 21 pessoas-chave (stakeholders), destas, duas farmacêuticas elaboradoras do manual de diluição institucional e 19 profissionais usuárias(os) do documento que atendem unidades assistenciais do adulto e pediátricas – Farmácia, Medicina, Enfermagem (Enfermeiras e Técnicas de Enfermagem). Entrevistas semiestruturas foram realizadas, confrontando-se o MTL preliminar com o entendimento prático dos profissionais sobre o manual. Construiu-se sistema de categorização baseado no corpus das entrevistas, com gerenciamento de dados por software Excel® (Pacote Microsoft Office 2007). A maioria dos participantes era profissional do sexo feminino, com tempo de atuação no Complexo HUPES de até cinco anos. Verificou-se que o manual é primeira fonte de consulta da maioria das(os) usuárias(os) e a maioria sabe acessá-lo; todos o consideram útil; a maioria já teve dificuldades em utilizá-lo e a principal necessidade de melhoria identificada foi a de realização de educação continuada. Perguntas avaliativas estão apresentadas. Ao final recomendou-se melhor respaldo e maior divulgação do manual de diluição nas políticas/normas institucionais e, apesar de aparentemente consolidado, treinamento sobre o manual de diluição mostra-se fundamental.
Application of renewable materials in energy saving of new building solar greenhouse
Authors: Li Xuan
Published: May 2022

This paper studies the application of renewable materials in the energy
saving of new building solar greenhouse, and analyzes the influence of
different building materials on the energy saving of solar greenhouse, it
can adjust the angle of the sunlight greenhouse roof manually to improve the
solar radiation into the room and adjust the fan system manually to increase
the heat storage of the back wall. The test greenhouse located in a modern
production base of a city was measured, and the test data under different
weather conditions in winter of 2020 were selected to analyze the
characteristics of temperature and light data indexes in the renewable
material solar greenhouse and common material solar greenhouse, and the
active lighting mechanism and active heat storage mechanism of the
renewable material new building solar greenhouse were theoretically
studied. The results show that the average light transmittance and indoor
illumination of the solar greenhouse with recycled materials are increased
compared with that of ordinary materials under different weather conditions
in winter. In winter solstice, cloudy days and sunny days, the light
transmittance of active daylighting and heat storage solar greenhouse was
61.17%, 58.26%, and 70.81%, respectively, which was 7.87%, 5.88%, and 11.45%
higher than that of ordinary energy-saving solar greenhouse, and the
corresponding indoor illumination was 15.42%, 11.73%, and 21.28% higher than
that of ordinary energy-saving solar green?house. In terms of temperature,
under different weather conditions in winter, the indoor temperature and
ground temperature of the solar greenhouse with active daylighting and heat
storage are significantly higher than those of the control material
energy-saving solar greenhouse. The temperature difference between indoor
and outdoor is above 27?C.
Enhancing and Updating Cohen, Dey, and Lys’s (2008) Methodological Framework to Re-Examine the Relation between Accrual-Based and Real Earnings Management after SOX
Authors: Pincus Morton , Wu Shijia
Published: May 2022

We respond to and rebut a number of comments in Daniel Cohen and Thomas Lys’s commentary (Cohen and Lys 2022) on our paper (Pincus et al. 2022), which re-examines and extends the research in Cohen, Dey, and Lys (2008), “(hereinafter CDL)”. Specifically, we rebut most of the claims Cohen and Lys (2022) make regarding the lack of a conceptual framework and research design limitations and clarify Cohen and Lys's (2022) misinterpretation on the inconsistency between our findings and prior published work. Cohen and Lys (2022) argue for the need to adjust the methodology that Cohen et al. (2008) employed but fail to acknowledge the enhancements we made to Cohen et al. (2008) methodological framework, which enabled us to separate the substitution effects associated with the pre-SOX and post-SOX periods.
Causal Graph Among Serum Lipids and Glycemic Traits: A Mendelian Randomization Study
Authors: Zhu Ziwei , Wang Kai , Hao Xingjie , Chen Liangkai , Liu Zhonghua , Wang Chaolong
Published: May 2022

We systematically investigated the bidirectional causality among HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), triglycerides (TGs), fasting insulin (FI), and glycated hemoglobin A1c (HbA1c) based on genome-wide association summary statistics of Europeans (n = 1,320,016 for lipids, 151,013 for FI, and 344,182 for HbA1c). We applied multivariable Mendelian randomization (MR) to account for the correlation among different traits and constructed a causal graph with 13 significant causal effects after adjusting for multiple testing (P < 0.0025). Remarkably, we found that the effects of lipids on glycemic traits were through FI from TGs (β = 0.06 [95% CI 0.03, 0.08] in units of 1 SD for each trait) and HDL-C (β = −0.02 [−0.03, −0.01]). On the other hand, FI had a strong negative effect on HDL-C (β = −0.15 [−0.21, −0.09]) and positive effects on TGs (β = 0.22 [0.14, 0.31]) and HbA1c (β = 0.15 [0.12, 0.19]), while HbA1c could raise LDL-C (β = 0.06 [0.03, 0.08]) and TGs (β = 0.08 [0.06, 0.10]). These estimates derived from inverse-variance weighting were robust when using different MR methods. Our results suggest that elevated FI was a strong causal factor of high TGs and low HDL-C, which in turn would further increase FI. Therefore, early control of insulin resistance is critical to reduce the risk of type 2 diabetes, dyslipidemia, and cardiovascular complications.
Effect of De-intensifying Diabetes Medications on Negative Events in Older Veteran Nursing Home Residents
Authors: Niznik Joshua D. , Zhao Xinhua , Slieanu Florentina , Mor Maria K. , Aspinall Sherrie L. , Gellad Walid F. , Ersek Mary , Hickson Ryan P. , Springer Sydney P. , Schleiden Loren J. , Hanlon Joseph T. , Thorpe Joshua M. , Thorpe Carolyn T.
Published: May 2022

Objective: Guidelines advocate against tight glycemic control in older nursing home (NH) residents with advanced dementia (AD) and/or limited life expectancy (LLE). We evaluated the effect of de-intensifying diabetes medications on all-cause emergency department (ED) visits, hospitalizations, and death in NH residents with LLE/AD and tight glycemic control.

Research Design and Methods: We conducted a national retrospective cohort study of 2,082 newly admitted non-hospice Veteran NH residents with LLE/AD potentially overtreated for diabetes (HbA1c ≤7.5% and ≥1 diabetes medication) in fiscal years 2009-2015. Diabetes treatment de-intensification (dose decrease or discontinuation of a non-insulin agent or stopping insulin sustained ≥7 days) was identified within 30 days following HbA1c measurement. To adjust for confounding, entropy weights were used to balance covariates between NH residents who de-intensified vs. continued medications. We used the Aalen-Johansen estimator to calculate the 60-day cumulative incidence and risk ratios (RR) for ED or hospital visits and deaths. 

Results: Diabetes medications were de-intensified for 27%. In the subsequent 60 days, 28.5% of all residents were transferred to the ED or acute hospital setting for any cause and 3.9% died. After entropy weighting, de-intensifying was not associated with 60-day all-cause ED visits or hospitalizations (RR = 0.99 [0.84, 1.18]) or 60-day mortality (RR = 1.52 [0.89-2.81]). 

Conclusion: Among NH residents with LLE/AD who may be inappropriately overtreated with tight glycemic control, de-intensification of diabetes medications was not associated with increased risk of 60-day all-cause ED visits, hospitalization, or death in NH residents with LLE/AD.
Targeting pancreatic islet NLRP3 improves islet graft revascularization
Authors: Wrublewsky Selina , Speer Thimoteus , Nalbach Lisa , Boewe Anne S. , Pack Mandy , Alansary Dalia , Roma Leticia P. , Hoffmann Markus D. A. , Schmitt Beate M. , Weinzierl Andrea , Menger Michael D. , Laschke Matthias W. , Ampofo Emmanuel
Published: May 2022

  

Hypoxia-induced islet cell death, caused by an insufficient revascularization of the grafts, is a major obstacle for successful pancreatic islet transplantation. Recently, it has been reported that the nucleotide-binding oligomerization domain (NOD)-like receptor protein (NLRP)3 inflammasome is expressed in pancreatic islets and its loss protects against hypoxia-induced cell death. Therefore, we hypothesized that the inhibition of NLRP3 in islets improves the survival and endocrine function of the grafts. The transplantation of Nlrp3-/- islets or WT islets exposed to the NLRP3 inhibitor CY-09 into mouse dorsal skinfold chambers resulted in an improved revascularization when compared to controls. An increased insulin release after NLRP3 inhibition caused the enhanced angiogenic response. Moreover, the inhibition of NLRP3 in hypoxic β-cells triggered insulin gene expression by inducing the shuttling of MafA as well as pancreatic and duodenal homeobox (PDX)-1 into the nucleus. This was mediated by a reduced interaction of NLRP3 with the thioredoxin-interacting protein (TXNIP). Transplantation of Nlrp3-/- islets or WT islets exposed to CY-09 under the kidney capsule of diabetic mice markedly improved the restoration of normoglycemia. These findings indicate that the inhibition of NLRP3 in isolated islets represents a promising therapeutic strategy to improve engraftment and function of the islets.
Variasi Nilai Tegangan Percik Arrester Akibat Pengaruh Kapasitas Trafo Daya dan Jarak Arrester
Authors: Oktaviani Wiwin A , Septiaji Rahmat , Taufik Barlian
Published: May 2022

The ability of each substation to withstand lightning and overvoltage affects the power distribution of the power system. In order to make the best operation of the substations, it is necessary to install Arresters which are used to protect the transformers in each substation from overvoltage caused by lightning surges. In this study, the effect of capacity on the placement distance of the arrester is discussed with 30 MVA and 60 MVA transformers. The purpose of this study was to determine the effect of the power transformer capacity of the four substations on the value of the arrester spark voltage and to obtain the optimal arrester installation technique at each substation using the Lagrange optimization method. Lagrange optimization method is used to determine the optimal distance between the arrester and the power transformer. The calculation results show that in a transformer with a capacity of 60 MVA, the Arrester spark voltage occurs at t = 20 microseconds with a voltage drop of 390.49 kV. Meanwhile, in a transformer with a capacity of 30 MVA, the Arrester spark time is at t = 13.9 microseconds with a voltage drop of 266.3 kV. This shows the capacity of the transformer that affects the magnitude of the Arrester's spark voltage and the spark time. Thus, the smaller the transformer capacity, the smaller the arrester spark time with the large voltage drop