bluuebunny/crossref_metadata_2025 huggingface dataset:
C1GALT1 expression is associated with galactosylation of IgA1 in peripheral B lymphocyte in immunoglobulin A nephropathy
Authors: Xing Yue , Li Lina , Zhang Yaru , Wang Fanghao , He Dandan , Liu Youxia , Jia Junya , Yan Tiekun , Lin Shan
Published: September 2019

Background

More and more studies demonstrated that genetic variation at C1GALT1 influences Gd-IgA1 level in IgAN. However, whether the expression of β1, 3-galactosyltransferase (β1, 3Gal-T) was influenced may provide insights into how Gd-IgA1 levels are controlled in IgAN.

Methods

Thirty IgAN patients diagnosed in Tianjin Medical University General Hospital from April to September 2018 and 30 healthy volunteers whose age and gender matched with patients were enrolled in this study. Total Gd-IgA1 levels in plasma were determined by ELISA and C1GALT1 levels were determined by RT-PCR. Four databases (PubMed, EMBASE, CNKI, WanFang Medical Network) were searched to identify eligible studies that evaluated a difference in the expression of C1GALT1 in IgAN patients compared with total controls (non-IgAN and health controls). The C1GALT1C1 expression levels, which was indispensable to β1, 3Gal-T of IgA1, was also been compared.

Results

Gd-IgA1 levels were remarkable higher in IgAN patients compared with healthy control. The expression levels of C1GALT1 gene were remarkably down-regulated in IgAN patients compared with healthy control. And the mRNA level of C1GALT1 was inversely correlated to Gd-IgA1 levels. In meta-analysis, six articles including 316 participants that analyzed the expression of β1, 3Gal-T were met inclusion criteria. There was no significant difference in the expression of C1GALT1 between IgAN patients compared with controls. And we found patients with IgAN had lower levels of C1GALT1 gene expression in the B cells compared to controls. The C1GALT1C1 levels in the IgAN patients were not different from the levels in the control group, which were unchanged no matter according to different ethnic population, different control group and different cell source. Two studies including 46 persons compared enzymatic activity of β1, 3Gal-T in B cells, and the result showed the β1, 3Gal-T activity was decreased in B cells.

Conclusions

We found expression levels of C1GALT1 were remarkably downregulated in IgAN patients and negatively correlated with higher levels of Gd-IgA1. Subsequent meta-analysis validated the low expression and activity of β1, 3Gal-T in B cells in patients with IgAN. However, there was no apparent disparity in the aspect of C1GALT1C1 expression between IgAN and control groups.
Factors associated with unintended pregnancy in Ethiopia; further analysis of the 2016 Ethiopian demographic health survey data.
Authors: Bekele Yibeltal Alemu , Fekadu Gedefaw Abeje
Published: September 2019

Background Unintended pregnancy is an important public health problem in Ethiopia. It causes adverse physical, mental, social and economic outcomes. Identifying factors associated with unintended pregnancy may help to reduce unintended pregnancy and hence adverse outcomes. There are few studies about the prevalence and associated factors of unintended pregnancy in Ethiopia. But these studies were based on few sample size and fragmented. Therefore, this analysis was done to identify factors associated with unintended pregnancy in Ethiopia based on nationally representative data.Methods The study used the 2016 Ethiopian demographic and health survey data. The data was downloaded from The DHS program with permission. A total of 1135 women were included in the final model. Data was weighted to consider disproportionate sampling and non-response. Multivariable logistic regression was used to identify factors associated with unintended pregnancy among women.Result About 30% (95% CI: 25.33 -34.39) pregnancies were unintended. Married women (AOR; 0.34; 95% CI: 0.01- 0.14), woman living in developing regions (AOR; 0.14; 95% CI: 0.07- 0.27) and women who reported distance not a big problem to get medical care (AOR 0.59; 95% CI: 0.36 - 0.99) had lower odds of unintended pregnancy. On the other hand, multi-para (AOR; 3.77; 95% CI: 1.71 - 8.33), grand multi-para (AOR; 6.72; 95% CI: 2.74 - 16.49) women and women who ever used contraceptives (AOR; 1.86 95% CI: 1.06 - 3.26) had higher odds of unintended pregnancy.Conclusion Although high,the magnitude of unintended pregnancy in Ethiopia was lower compared to the global level. Marital status, region, perceived distance to seek medical care, parity and history of contraceptive use were found significant predictors of unintended pregnancy in Ethiopia.
Clinical utility of PEG-G-CSF for preventing severe neutropenia in metastatic colorectal cancer patients treated with FOLFOXIRI plus bevacizumab: A single centor retrospective study
Authors: Yusuke Kitagawa , Osumi Hiroki , Shinozaki Eiji , Ota Yumiko , Nakayama Izuma , Suzuki Takeshi , Wakatsuki Takeru , Ogura Mariko , Ooki Akira , Takahari Daisuke , Suenaga Mitsukuni , Chin Keisho , Yamaguchi Kensei
Published: September 2019

Background: This study aimed to evaluate in clinical practice the efficacy and safety of polyethylene glycol conjugated granulocyte colony-stimulating factor (PEG-G-CSF) for preventing neutropenia in metastatic colorectal cancer (mCRC) patients that received fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) plus bevacizumab (Bev). Methods: We retrospectively analyzed mCRC patients who received FOLFOXIRI plus Bev between December 2015 and December 2017. We evaluated the efficacy of PEG-G-CSF for treating neutropenia, the overall response rate (ORR) according to the Response Evaluation Criteria in Solid Tumors version 1.1, progression free survival (PFS), overall survival (OS), and adverse events of FOLFOXIRI plus Bev based on the Common Terminology Criteria for Adverse Events version 4.0. Results: A total of 26 patients (median age 53.5 years) were included. The ORR rate was 65.3%, the median PFS was 9.6 months (7.2–16.9), and the median OS was 24.2 months (13.6–NA). Grade 3 or 4 neutropenia occurred in 53.8% of the patients and febrile neutropenia occurred in 7.7%. PEG-G-CSF was given to 77.0% of the patients, including prophylactically (n = 9) and after the development of grade 3 or 4 neutropenia (n = 11). No patients experienced grade 3 or higher neutropenia after the administration of PEG-G-CSF. In seven of the nine patients who received PEG-G-CSF prophylactically (77.7%), no dose adjustment was required.Conclusions: PEG-G-CSF was useful in preventing severe neutropenia in mCRC patients treated with FOLFOXIRI plus Bev.
Electrochemical oxidation treatment of coal tar wastewater with lead dioxide anodes
Authors: Zhao Qiang , Wei Feng , Zhang Liman , Yang Yang , Lv Shuang , Yao Yingwu
Published: September 2019

In this study, coal tar wastewater was treated by electrochemical oxidation technology using lead dioxide anodes. The influence of operating parameters, including applied current density, electrode gap and initial pH value, on the removal ratio of chemical oxygen demand (COD) was investigated. The results demonstrated that the COD removal ratio reached 90.5% after 3.5 h electrolysis with the current density at 3 A dm−2 and electrode gap at 1.0 cm. Correspondingly, the COD decreased from 5,125 mg L−1 to 487 mg L−1, which fitted the wastewater discharge standards of China, and the specific energy consumption (SECCOD) was 35.3 kWh kgCOD−1. Not only was the COD removal ratio only 77.1% after 2 h electrolysis but the BOD5/COD ratio of the wastewater reached 0.44, which could be biochemically treated, and the SECCOD decreased by 34.3%. Moreover, the main composition of pristine wastewater before and after 2 h electrolysis was analyzed by GC-MS, and the disappearance of macromolecules (such as ethyl-2-pyrenemethanol) and the production of small molecules (such as propane-1,3-diol) could improve the biodegradability of the wastewater. Therefore, electrochemical oxidation for 2 h is a promising alternative for pretreatment of coal tar wastewater prior to biological treatment.
Naturally Occurring Organic Acid-catalyzed Facile Diastereoselective Synthesis of Biologically Active (E)-3-(arylimino)indolin-2-one Derivatives in Water at Room Temperature
Authors: Kaur Gurpreet , Singh Arvind , Bala Kiran , Devi Mamta , Kumari Anjana , Devi Sapna , Devi Rekha , Gupta Vivek Kumar , Banerjee Bubun
Published: September 2019

A simple, straightforward and efficient method has been developed for the synthesis
of (E)-3-(arylimino)indolin-2-one derivatives and (E)-2-((4-methoxyphenyl)imino)-
acenaphthylen-1(2H)-one. The synthesis of these biologically-significant scaffolds was
achieved from the reactions of various substituted anilines and isatins or acenaphthaquinone,
respectively, using commercially available, environmentally benign and naturally
occurring organic acids such as mandelic acid or itaconic acid as catalyst in aqueous medium
at room temperature. Mild reaction conditions, energy efficiency, good to excellent
yields, environmentally benign conditions, easy isolation of products, no need of column
chromatographic separation and the reusability of reaction media are some of the significant
features of the present protocol.
Lipid-based Vehicles for siRNA Delivery in Biomedical Field
Authors: Li Tianzhong , Huang Linfeng , Yang Mengsu
Published: September 2019

Background:

Genetic drugs have aroused much attention in the past twenty years. RNA interference
(RNAi) offers novel insights into discovering potential gene functions and therapies targeting
genetic diseases. Small interference RNA (siRNA), typically 21-23 nucleotides in length, can specifically
degrade complementary mRNA. However, targeted delivery and controlled release of siRNA
remain a great challenge.

Methods:

Different types of lipid-based delivery vehicles have been synthesized, such as liposomes,
lipidoids, micelles, lipoplexes and lipid nanoparticles. These carriers commonly have a core-shell
structure. For active targeting, ligands may be conjugated to the surface of lipid particles.

Results:

Lipid-based drug delivery vehicles can be utilized in anti-viral or anti-tumor therapies. They
can also be used to tackle genetic diseases or discover novel druggable genes.

Conclusion:

In this review, the structures of lipid-based vehicles and possible surface modifications
are described, and applications of delivery vehicles in biomedical field are discussed.
Combination of Mechanical and Chemical Methods Improves Gene Delivery in Cell-based HIV Vaccines
Authors: Soleymani Sepehr , Hadi Amin , Asgari Fatemeh , Haghighipour Nooshin , Bolhassani Azam
Published: September 2019

Objective:

Novel vaccination approaches are required to control human immunodeficiency
virus (HIV) infections. The membrane proximal external region (MPER) of Env gp41 subunit and the
V3/glycans of Env gp120 subunit were known as potential antigenic targets for anti-HIV-1 vaccines. In
this study, we prepared the modified dendritic cells (DCs) and mesenchymal stem cells (MSCs) with
HIV-1 MPER-V3 gene using mechanical and chemical approaches.

Methods:

At first, MPER-V3 fusion DNA delivery was optimized in dendritic cells (DCs) and mesenchymal
stem cells (MSCs) using three mechanical (i.e., uniaxial cyclic stretch, equiaxial cyclic stretch
and shear stress bioreactors), and two chemical (i.e., TurboFect or Lipofectamine) methods. Next, the
modified DCs and MSCs with MPER-V3 antigen were compared to induce immune responses in vivo.

Results:

Our data showed that the combination of equiaxial cyclic stretch loading and lipofectamine
twice with 48 h intervals increased the efficiency of transfection about 60.21 ± 1.05 % and 65.06 ± 0.09
% for MSCs and DCs, respectively. Moreover, DCs and MSCs transfected with MPER-V3 DNA in
heterologous DC or MSC prime/ peptide boost immunizations induced high levels of IgG2a, IgG2b,
IFN-γ and IL-10 directed toward Th1 responses as well as an increased level of Granzyme B. Indeed,
the modified MSCs and DCs with MPER-V3 DNA could significantly enhance the MPER/V3-specific
T-cell responses compared to MPER/V3 peptide immunization.

Conclusion:

These findings showed that the modified MSC-based immunization could elicit effective
immune responses against HIV antigen similar to the modified DC-based immunization.
Effect of Filler Content and Waiting time Before Light-Curing on Mechanical Properties of Dual-Cured Cement
Authors: Oliveira Ana C. de Assunção , Griza Sandro , de Moraes Rafael R. , Faria-e-Silva André L.
Published: September 2019

Objective::

To investigate the effect of filler content and the time spent before light-curing
on mechanical properties of dual-cured cement.

Methods::

Experimental dual-cured resin cements were formulated with 60, 65 or 68wt% of filler.
The viscosity of experimental cement was measured using a digital viscometer. Bar-shaped specimens
(25 x 2 x 2 mm) were fabricated, while the light-curing was started immediately or 5 minutes
after the insertion of cement into the mold (n = 7). A three-point bending test was performed and the
values of flexural strength and elastic modulus were measured. The Vickers hardness of fractured
specimens was measured on the surface of the cement. Data from viscosity were submitted to oneway
ANOVA, while the data from mechanical properties were analyzed by two-way ANOVA. All
pair-wise comparisons were performed using Tukey’s test (α = 0.05).

Results::

The experimental cement with 68wt% of filler showed the highest viscosity and those with
60wt% showed the the lowest viscosity. Irrespective of the time spent before light-curing, the cement
with 65wt% of filler presented the highest values of flexural strength and elastic modulus. The
addition of 60wt% of filler resulted in the lowest elastic modulus, while 68wt% of filler resulted in
lowest flexural strength. Regarding the hardness, the cement with 68wt% of filler showed the highest
values, while there was no difference between 60 and 65wt% of filler.

Conclusion::

Filler content affected the mechanical properties of the experimental cement and this
effect did not depend on the waiting time before the light-curing procedure.
A critical review of Garbhini Ksheerapakas mentioned in Ayurvedic texts of Kerala
Authors: Meghna PP , Surendran Emy , Sumedhan Varsha J. , Sinimol TP
Published: September 2019

Pregnancy is an important phase in a woman’s life. Health of the pregnant woman has a major role in reducing adverse pregnancy outcomes. Sahasrayoga and Arogyakalpadruma are two important Ayurveda texts of Kerala origin which has references on ante natal care. Both these texts advocates the intake of Ksheerapakas of various drugs, throughout the pregnancy period. It is also a traditional practice to use these medications during antenatal period in many parts of Kerala. This paper aims to review the drugs used for Ksheerapaka and to assess their possible benefits in pregnancy.
Prediksi Prognosis Penderita Trauma Kapitis Berdasarkan Gambaran CT scan Kepala
Authors: Husnah Kurniawati , Murtala Bachtiar , Asriyani Sri , Zainuddin Andi Alfian , Mustamir Nasrullah , Latief Nikmatia
Published: September 2019

Trauma kapitis memiliki penyebab, patologi, tingkat keparahan dan prognosis yang berbeda-beda sehingga diperlukan prediktor terpercaya untuk menilai luaran pasien. CT scan berperan penting dalam mengevaluasi kerusakan struktural pada fase akut trauma kapitis. Penelitian ini bertujuan menilai gambaran CT scan kepala dalam memprediksi prognosis penderita trauma kapitis. Penelitian ini merupakan penelitian retrospektif terhadap 444 penderita trauma kapitis ringan sampai berat yang dilakukan pemeriksaan CT scan kepala di RSUP Dr. Wahidin Sudirohusodo Makassar selama periode Januari-Juni 2018. Peneliti mengidentifikasi gambaran CT scan yang berpengaruh terhadap mortalitas pasien. Hasil penelitian menunjukkan bahwa status sisterna basalis (compressed, OR=31.690, absent, OR=11.092, p<0.0001), midline shift (OR=2.889, p<0.0001), dan pendarahan subarachnoid atau intraventrikel (OR=6,977, p<0.0001) merupakan prediktor independen mortalitas penderita trauma kapitis.
Dukungan Keluarga meningkatkan Kepatuhan Minum Obat pada Penderita Tuberkulosis Paru di Kabupaten Tapanuli Utara
Authors: Siregar Idawaty , Siagian Parluhutan , Effendy Elmeida
Published: September 2019

Salah satu penyakit yang masih menjadi permasalahan kesehatan di dunia termasuk Indonesia adalah tuberkulosis (TB) yang disebabkan oleh kuman Mycobacterium tuberculosis (M. tuberculosis). Keberhasilan pengobatan TB memerlukan kepatuhan penderita dalam minum obat anti tuberkulosis (OAT). Dukungan keluarga seperti pengawasan dan memberi motivasi kepada penderita TB merupakan faktor yang berperan dalam kepatuhan penderita. Penelitian ini dilakukan untuk mengetahui hubungan dukungan keluarga dengan kepatuhan minum obat pada penderita TB paru di Kabupaten Tapanuli Utara. Desain penelitian ini adalah cross sectional dengan responden 60 penderita TB paru kategori 1 dan 2 yang mendapat pengobatan minimal 1 bulan serta tinggal bersama keluarga. Penelitian dilaksanakan di Puskesmas Pangaribuan, Puskesmas Situmeang Habinsaran, dan Puskesmas Hutabaginda di Kabupaten Tapanuli Utara pada bulan Juni-September 2017. Responden diwawancarai dengan menggunakan pertanyaan kuesioner untuk mengumpulkan data. Hasil penelitian ini menunjukkan terdapat hubungan antara dukungan keluarga dengan kepatuhan minum obat pada penderita TB paru di Puskesmas Tapanuli Utara (p=0,002). Pada penelitian ini, dukungan keluarga yang baik meningkatkan kepatuhan penderita TB untuk minum obat anti tuberkulosis (OAT).
Pengaruh Pembelajaran dan Penilaian Keterampilan Klinis di Kepaniteraan Umum terhadap Tingkat Kesiapan Mahasiswa Kedokteran Melakukan Keterampilan Klinis di Tahap Profesi
Authors: Riskawati Yhusi Karina , Novita Khuznita Dasa , Pangestuti Dwiretno , Indradmojo Christyaji , Septiani Nila Dwi , Tanesa Gita , Syamsiatin Salis Zainah
Published: September 2019

Pembelajaran keterampilan klinis selama tahap akademik dan Objective Structural Clinical Examination (OSCE) dengan metode simulasi berbeda dengan situasi yang nyata terhadap pasien pada tahap Profesi. Penelitian ini bertujuan membuktikan pengaruh pembelajaran dan penilaian keterampilan klinis yang dinilai menggunakan perubahan persepsi kesiapan melakukan keterampilan klinis sebelum dan sesudah menjalani kepaniteraan umum dibandingkan ketika menjalani tahap Profesi. Studi Kohort dilakukan dengan menggunakan kuisioner persepsi tingkat kesiapan mahasiswa melakukan keterampilan klinis yang diberikan sebelum, setelah Panum dan saat awal Profesi. Jumlah responden dalam penelitian ini 126 mahasiswa Program Studi Profesi Dokter Universitas Brawijaya tahun ke-4. Hasil menunjukkan peningkatan kesiapan mahasiswa dalam melakukan keterampilan klinis sebelum dengan sesudah kepaniteraan umum/Panum (35,45,5 dan 39,26,0; p<0,05), namun tidak terjadi peningkatan ataupun penurunan kesiapan sesudah Panum dengan kesiapan di awal tahap Profesi (39,26,0 dan 39,26,1; p>0,05). Tidak ada hubungan signifikan nilai OSCE Panum dengan kesiapan mahasiswa dalam melakukan keterampilan klinis di tahap Profesi melalui uji korelasi Spearman-Rho (p>0,05). Proses pembelajaran keterampilan klinis di kepaniteraan umum berpengaruh positif meningkatkan kesiapan melakukan keterampilan klinis sebelum menjalani tahap Profesi hingga awal tahap Profesi. Tidak terdapat hubungan yang bermakna antara nilai OSCE Panum dengan kesiapan mahasiswa dalam melakukan keterampilan klinis di awal tahap Profesi. Perlu di lakukan modifikasi model pembelajaran keterampilan klinis untuk meningkatkan kesiapan mahasiswa dalam melakukan keterampilan klinis pada tahap Profesi.
Kinerja Kader dalam Pencegahan Stunting: Peran Lama Kerja sebagai Kader, Pengetahuan dan Motivasi
Authors: Afifa Irma
Published: September 2019

Salah satu upaya penanganan stunting melalui keterlibatan kader posyandu. Tujuan penelitian untuk menguji peranan pengetahuan dan motivasi sebagai variabel mediasi pengaruh lama menjadi kader terhadap kinerja kader dalam program pencegahan stunting di wilayah Puskesmas Pagelaran dan Gedangan. Metode penelitian menggunakan observasional analitik dengan pendekatan cross sectional. Populasi penelitian adalah dua puskesmas (705 kader), dengan sampel125 kader pada masing-masing puskesmas diambil secara proportional cluster random sampling. Kriteria responden yaitu kader posyandu yang aktif bekerja di wilayah Puskesmas Pagelaran atau Gedangan. Instrumen penelitian menggunakan kuesioner. Analisis uji beda Independet Sample T-Test digunakan untuk membandingkan lama menjadi kader, pengetahuan, motivasi, dan kinerja kader antara dua puskesmas. Analisis jalur digunakan untuk mengetahui pengaruh lama menjadi kader terhadap kinerja kader yang dimediasi pengetahuan dan motivasi kader pada masing-masing wilayah puskesmas. Transformasi data terlebih dulu dilakukan untuh merubah data ordinal menjadi interval dan dilakukan uji kesetaraan pada karakteristik responden meliputi usia, pendidikan, dan pekerjaan. Hasil penelitian menunjukkan pengetahuan dan kinerja kader terbukti berbeda signifikan, sedangkan lama menjadi kader dan motivasi kader tidak berbeda signifikan di kedua wilayah Puskesmas. Berdasarkan hasil analisis jalur pengetahuan dan motivasi kader tidak terbukti menjadi variabel mediasi lama menjadi kader terhadap kinerja kader serta lama menjadi kader tidak berpengaruh terhadap kinerja kader di kedua wilayah. Meskipun demikian, motivasi kader berpengaruh dominan terhadap kinerja kader di kedua wilayah Puskesmas.
Herpetofauna de la Estación Forestal Experimental Zoquiapan (EFEZ), México: Análisis de su diversidad en tres hábitats distintos
Authors: Pérez-Roblero Claudia Yaniris , Sánchez-Trejo Rubén , Corcuera Pablo , Zavala-Hurtado José Alejandro , Zárate-Hernández Rocío
Published: September 2019

Se analizaron los patrones de diversidad de anfibios y reptiles en tres hábitats distintos de un ambiente templado: Pino, Pino-Aile y Pino-Oyamel de la Estación Forestal Experimental Zoquiapan (EFEZ), en el área natural protegida Parque Nacional Iztaccíhuatl-Popocatépetl-Zoquiapan. Se realizaron muestreos sistemáticos de la herpetofauna en transectos en banda de 1,000 m de largo por 10 m de ancho, de 2015 (mayo-julio y septiembre-noviembre) a 2016 (enero-marzo). Se registró un total de 4,762 individuos correspondientes a siete familias, diez géneros y 15 especies (cinco anfibios y diez reptiles). Las familias con más especies y abundancia fueron Phrynosomatidae y Pletodontidae. La riqueza de especies fue mayor (15 especies) en el hábitat Pino-Aile, mientras que la abundancia fue significativamente más alta ( = 70.18 ind./ha) en el hábitat Pino. El hábitat Pino-Oyamel presentó la menor riqueza (13 especies) y abundancia ( = 36.66 ind./ha). La mayor diversidad (1D = 5.16) se registró en Pino-Aile, seguido por Pino-Oyamel (1D = 4.01) y Pino (1D = 3.84). La distribución de abundancias de las especies se ajustó a la serie logarítmica de Fisher. Las especies más comunes en los tres hábitats fueron Sceloporus grammicus y Pseudoeurycea leprosa, mientras que todas las serpientes se consideraron especies raras. El 86.7% de las especies son endémicas a México, de las cuales 69.2% son endémicas a la Faja Volcánica Transmexicana. El 33.3% de las especies están amenazadas y el 26.7% sujetas a protección especial en la NOM-059-2010. Cuatro de ellas están categorizadas por la IUCN, de las cuales 6.7% está en peligro, 13.3% es vulnerable y 6.7% está casi amenazada. En términos de la relación especies-área, la riqueza de especies de anfibios y reptiles, y la presencia de endemismos en la EFEZ son altas. Este estudio contribuye a un conocimiento sobre la riqueza, abundancia, distribución y diversidad de anfibios y reptiles de los hábitats templados de la estación, que sentará precedentes para el desarrollo de estrategias futuras de conservación de la biodiversidad y en particular de la herpetofauna.
PESQUISAS PÓS-CRÍTICAS EM EDUCAÇÃO: NOTAS METODOLÓGICAS PARA INVESTIGAÇÕES COM CURRÍCULOS DE GOSTO DUVIDOSO
Authors: Maknamara Marlécio , Paraíso Marlucy Alves
Published: September 2019

Este trabalho tem o objetivo de destacar algumas notas teórico-metodológicas em torno de pesquisas em educação que se pretendem pós-críticas. Inicia destacando algumas características de teorizações pós-críticas em educação. Em seguida, explicita motivos a partir dos quais é produtivo investigar, numa perspectiva pós-crítica, os ensinamentos de músicas. Adiante, considerando a produtividade de discursos musicais na constituição de posições de sujeito, destaca alguns procedimentos afeitos a pesquisas pós-críticas em educação que empregam análises discursivas segundo inspiração de Michel Foucault. Por fim, traz algumas considerações finais referentes ao compromisso de pesquisar e de tentar escrever pós-criticamente em educação, sobretudo em se tratando de investigar discursos musicais.
Learning Latent Space Representations to Predict Patient Outcomes: Model Development and Validation (Preprint)
Authors: Rongali Subendhu , Rose Adam J , McManus David D , Bajracharya Adarsha S , Kapoor Alok , Granillo Edgard , Yu Hong
Published: September 2019

BACKGROUND

Scalable and accurate health outcome prediction using electronic health record (EHR) data has gained much attention in research recently. Previous machine learning models mostly ignore relations between different types of clinical data (ie, laboratory components, International Classification of Diseases codes, and medications).

OBJECTIVE

This study aimed to model such relations and build predictive models using the EHR data from intensive care units. We developed innovative neural network models and compared them with the widely used logistic regression model and other state-of-the-art neural network models to predict the patient’s mortality using their longitudinal EHR data.

METHODS

We built a set of neural network models that we collectively called as long short-term memory (LSTM) outcome prediction using comprehensive feature relations or in short, CLOUT. Our CLOUT models use a correlational neural network model to identify a latent space representation between different types of discrete clinical features during a patient’s encounter and integrate the latent representation into an LSTM-based predictive model framework. In addition, we designed an ablation experiment to identify risk factors from our CLOUT models. Using physicians’ input as the gold standard, we compared the risk factors identified by both CLOUT and logistic regression models.

RESULTS

Experiments on the Medical Information Mart for Intensive Care-III dataset (selected patient population: 7537) show that CLOUT (area under the receiver operating characteristic curve=0.89) has surpassed logistic regression (0.82) and other baseline NN models (<0.86). In addition, physicians’ agreement with the CLOUT-derived risk factor rankings was statistically significantly higher than the agreement with the logistic regression model.

CONCLUSIONS

Our results support the applicability of CLOUT for real-world clinical use in identifying patients at high risk of mortality.

CLINICALTRIAL
Healthy Dietary Patterns and Incidence of CKD
Authors: Bach Katrina E. , Kelly Jaimon T. , Palmer Suetonia C. , Khalesi Saman , Strippoli Giovanni F. M. , Campbell Katrina L.
Published: September 2019

Background and objectives

Whether a healthy dietary pattern may prevent the incidence of developing CKD is unknown. This study evaluated the associations between dietary patterns and the incidence of CKD in adults and children.

Design, setting, participants, & measurements

This systematic review and meta-analysis identified potential studies through a systematic search of MEDLINE, Embase and references from eligible studies from database inception to February 2019. Eligible studies were prospective and retrospective cohort studies including adults and children without CKD, where the primary exposure was dietary patterns. To be eligible, studies had to report on the primary outcome, incidence of CKD (eGFR<60 ml/min per 1.73 m2). Two authors independently extracted data, assessed risk of bias and evidence certainty using the Newcastle–Ottawa scale and GRADE.

Results

Eighteen prospective cohort studies involving 630,108 adults (no children) with a mean follow-up of 10.4±7.4 years were eligible for analysis. Included studies had an overall low risk of bias. The evidence certainty was moderate for CKD incidence and low for eGFR decline (percentage drop from baseline or reduced by at least 3 ml/min per 1.73 m2 per year) and incident albuminuria. Healthy dietary patterns typically encouraged higher intakes of vegetables, fruit, legumes, nuts, whole grains, fish and low-fat dairy, and lower intakes of red and processed meats, sodium, and sugar-sweetened beverages. A healthy dietary pattern was associated with a lower incidence of CKD (odds ratio [OR] 0.70 (95% confidence interval [95% CI], 0.60 to 0.82); I
2=51%; eight studies), and incidence of albuminuria (OR 0.77, [95% CI, 0.59 to 0.99]; I
2=37%); four studies). There appeared to be no significant association between healthy dietary patterns and eGFR decline (OR 0.70 [95% CI, 0.49 to 1.01], I
2=49%; four studies).

Conclusions

A healthy dietary pattern may prevent CKD and albuminuria.
THE IMPACT OF CASSYTHA FILIFORMIS BUTANOL FRACTION TO THE PREGNANCY AND FETAL DEVELOPMENT ON MICE
Authors: NAZAR ARMENIA , AYUNING FIRLICIA , AHMADIN ALMAHDY
Published: September 2019

The impact of Cassytha filiformis butanol fraction to the pregnancy and fetal development had been conducted. The fertilized mice were treated withbutanol fraction of C. filiformis at doses of 2.5; 5; 10; and 20 mg/kg of body weight (BW) orally for 5 consecutive days during first, second, and thirdperiods of pregnancy. Parent BW was monitored and the fetal number, BW, death and/or resorptive site and defect were measured. ANOVA followedby Duncan multiple range test (significance at p<0.05) was performed to analyze data. The parent weight was reduced according to fraction doseand the period of pregnancy and the interaction of those factors (p<0.01). Only one mouse treated during the first period became pregnant with lessfetus number (p<0.05) but all of treated during the second and third period but death, resorptive site and underdeveloped fetus were found. Theseindicated the butanol fraction of C. filiformis produced infertility and slowed pregnancy development and produce fetal defect on mice.
SYNTHESIS AND ANTIOXIDANT EVALUATION OF 3-BROMO-FLAVONE
Authors: MASYITA AYU , YULIANTY RISFAH , RIFAI YUSNITA
Published: September 2019

Objective: The objective of the study was to obtain a flavone derivative compound through N-bromosuccinimide (NBS) reducing the reaction. Theantioxidant activity of the synthetic compound was then assayed by the 2,2-diphenyl-1-picrylhydrazyl method.Methods: Chalcone (3 mmol) as intermediate precursor was suspended with dimethyl sulfoxide and reacted with NBS (3 mmol), stirred at roomtemperature for 25 min and diluted in cold water. The synthesis of flavone derivatives resulted in yellow crystalline powder, freely soluble in methanoland ethanol, renamed 60% with a melting point of 87.7°C. Detection by thin-layer chromatography using hexane:chloroform (2:1) showed single spotwith Rf = 0.38 which is different from the Rf value of the starting compound (chalcone, 0.66 and 0.78).Results: The results of the characterization of the synthesized compound using ultraviolet-visible and Fourier transform-infared showed the groupcharacteristic containing C=C (1604.77 and 1639.49 cm-1), C=O (1681.93 cm-1), C-O-C (1242.16 cm-1), Ar-H (3032.1 and 3062.96 cm-1), and C-Br(663.51 cm-1) at maximum absorption of wavelength 253 nm.Conclusion: The synthesis of flavone using NBS resulted in 3-bromo-flavone with a weak antioxidant activity.
Crisis de la modernidad: un asalto a la razón
Authors: Careaga Gabriel
Published: September 2019

La idea de progreso nace en el siglo xvi y es el resultado de la visión optimista del mundo en el Renacimiento: la modernidad. El siglo xix es el triunfo de la teoría del progreso en sus dos versiones: liberalismo y marxismo. El siglo XX, con el gran desarrollo de la ciencia y la técnica, encuentra los límites de la razón: el hombre empieza a desconfiar de la inteligencia como instrumento de interpretación del mundo. Reflexiones sobre estos límites, sobre la irracionalidad del mundo actual, la necesidad de una crítica social de los sistemas políticos y económicos y de la discusión sobre la democracia, el poder y la libertad, rescatando la utopía.
De rerum natura y la búsqueda
Authors: Hajduk T.
Published: September 2019

Tadeusz Hajduk, Notas de una búsqueda perenne, Buenos Aires, E. Hastinapura, 1985.
Fe cristiana, religiones y esoterismo
Authors: Mendoza Alvarez Op. Carlos
Published: September 2019

Breve ensayo en tomo a la fe cristiana y su diferencia con algunas corrientes esotéricas que promueven una experiencia de espiritualidad. Las categorías teológicas de lo sagrado y lo santo; la “transmisión” de la sabiduría y el conocimiento sobre Dios; el esoterismo judeo-cristiano.
Posgrado y desarrollo en América Latina
Authors: Delgadillo Ibarra Ana Lilia
Published: September 2019

Reseña del libro de Abelardo Villegas, compilador, Posgrado y desarrollo en América Latina, México, Unión de Universidades de América Latina, Colección UDUAL, 1992.
La política de salud de la OMS: propuesta para los países en "vías de desarrollo”
Authors: Jablonska Alejandra
Published: September 2019

La congruencia de la propuesta de política de salud de la Organización Mundial de la Salud (OMS) en sus planteamientos básicos acerca de la sociedad, sus relaciones internas, el papel del Estado, así como elementos que influyen en el proceso salud-enfermedad, permiten conocer mejor su orientación e implicaciones. Un análisis de los planteamientos centrales de la legislación mexicana en este campo revela que la problemática de salud es abordada por las autoridades mexicanas desde la misma óptica y, por lo tanto, con propósitos análogos: legitimar al régimen político, solucionar los niveles mínimos de demandas sociales y asegurar condiciones mínimas de productividad, todo ello sin alterar las relaciones de producción existentes y sin hacer mayores erogaciones en los servicios de salud.
Reflexiones sobre los paradigmas contemporáneos de análisis del movimiento obrero
Authors: Trentín Bruno
Published: September 2019

Conferencia dictada el día 14 de abril de 1994 y organizada por la Coordinación de Sociología de la División de Estudios de Posgrado.
Año XXIV (1978): núm. 91, 92 y 93-94
Authors: Autor Sin
Published: September 2019

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Año XXXVI (1991): núm. 143, 144, 145 y 146
Authors: Autor Sin
Published: September 2019

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Canadá: la federación más descentralizada del mundo
Authors: Castro Rea Julián
Published: September 2019

En Canadá, la manera en que se dividen las competencias entre los gobiernos provinciales y federal es estructuralmente conflictiva. Las instituciones de ese país favorecen dicho conflicto, y alimentan las tendencias centrífugas del poder. Por ello, Canadá se ha convertido en el sistema federal en el que las unidades subnacionales tienen más poder que en ningún otro Estado del mundo. Aun así, las provincias no cesan de reclamar más facultades y beneficios del gobierno federal.
 La actual conformación del Parlamento federal y la elección de un partido con un claro programa independentista al gobierno de Quebec son desafíos de talla que la federación canadiense deberá enfrentar a corto plazo.
La democracia hegemónica, ¿hegemonía de la democracia?
Authors: Rodríguez Ledesma Xavier
Published: September 2019

El artículo parte de la premisa de que la noción específica del concepto de democracia afianzada a lo largo de este siglo, debe ser explicada de manera histórica para evidenciar el sentido político y cultural de la hegemonía, y ello sobre todo por el derrumbe del mundo socialista. Debido a que los fenómenos sociales específicos del mundo moderno atenían contra el espíritu de la justicia, la libertad y la igualdad que pareciera normarlos, es necesario pensar en las distintas acepciones que el concepto de la democracia pueda tener.
Democratización y cultura en México. Modernización, identidad nacional y resistencia cultural
Authors: Casas Pérez Ma. De la Luz
Published: September 2019

El presente artículo explora las relaciones entre los conceptos de modernización e identidad nacional, especialmente a la luz del reacomodo de fuerzas sociales y políticas que se dan en México a partir de 1994. Las premisas en tomo a las cuales gira la argumentación del presente trabajo son que en el proceso se han dado nuevos mecanismos de recomposición de la identidad; que la identidad nacional ha venido a ser reemplazada por nuevas formas de identidad conectadas a procesos culturales autónomos; y que éstas han venido a transformarse en mecanismos de resistencia cultural vinculados a estructuras emergentes de democratización.
Presentación
Authors: Nombre Sin
Published: September 2019

Presentación del n. 168 de la RMCPS
La universidad pública: esencia, misión y crisis
Authors: Kaplan Marcos
Published: September 2019

En este artículo, el autor se cuestiona sobre qué tipo de universidad queremos ser, cómo y por qué. En primer lugar, aclara, tenemos que recordar que la universidad es resultado de un complejo proceso histórico que involucró a todos los sectores sociales (económicos, religiosos, culturales, políticos, etcétera). En segundo lugar, la universidad es en sí misma una fuerza transformadora que promueve cambios en la sociedad con el poder del conocimiento.
 El autor concluye que la noción de autonomía universitaria debe significar libertad de cátedra y pensamiento, rechazando cualquier idea de exclusión o discriminación. Después de todo, la universidad es un producto social y como tal debe interactuar con su realidad inmediata y mediata: de las ideas a las acciones sólo hay un paso, pero este paso debe darse prudentemente.
Pendapatan Non Halal Perbankan Syariah di Indonesia: Analisis Sumber dan Penggunaannya
Authors: Hartanto Rudy , Pramono Irena Paramita , Purnamasari Pupung
Published: September 2019

The existence of the regulation for Islamic banking causes it to conduct their activities by the guidance of Islamic principles which avoid some non-halal sources of income. On the other hand, the transactions between Islamic banking and conventional banking are unavoidable because conventional financial institutions still dominate all transactions in each country. Means that non-halal sources of income cannot be avoided, by the way of the transaction is done. This research aims to analyze the sources of income and its distribution of the non-halal funds of Islamic Banks in Indonesia. This research is quantitative. The method of collecting data documentation uses data from 2015-2017 with a total sample of 102 Islamic banks. The results show that there were differences in the average non-halal funds of Islamic Commercial Banks with Islamic Business Unit Bank. In addition, this study shows that Islamic commercial bank tends to have non-halal funds bigger than Islamic Business Unit Bank. On the other hand, the result shows that non-halal funds sources in the banking industry are dominated by interest income from another conventional bank and the using of non-halal funds is dominated by social activities.
Estimación de los gases efecto invernadero generados por las plantas de tratamiento de aguas residuales ubicadas en la cuenca del río Bogotá
Authors: Cristancho Montenegro Diana Lucía , Gámez Posada Wilson , Guerra Alfaro Jorge Armando , Dueñas Escudero María Fernanda
Published: September 2019

El presente estudio contiene un análisis de datos que relaciona la carga orgánica presente en las plantas de tratamiento de aguas residuales (PTAR) de la cuenca del río Bogotá y su incidencia en la generación de gases efecto invernadero (GEI) durante el proceso de depuración. Dentro del análisis se recopiló una serie de consideraciones técnicas relacionadas con la generación de GEI de las diferentes PTAR que hacen parte de la cuenca. De acuerdo con las características del sistema empleado en el tratamiento de las aguas residuales, se determina cuál proceso genera mayor aporte de emisiones, teniendo en cuenta el estado actual de cada planta. Para ello, se emplea la metodología nivel 1 del Grupo Intergubernamental de Expertos sobre el Cambio Climático (IPCC) para los inventarios de GEI. Con base en los resultados obtenidos, se identifica cuáles sistemas de tratamiento empleados en las PTAR inciden en mayor proporción en la emisión de GEI.
Propuesta de mejora de procesos software basada en PSP para contextos de teletrabajo
Authors: Giraldo Fáber D. , Villegas Arias Mónica Michelle
Published: September 2019

En este artículo se presenta una propuesta de especificación de mejora en el proceso software para contextos de teletrabajo basada en el framework Personal Software Process (PSP) del Software Engineering Institute (SEI). La propuesta describe una especificación de un proceso software, para que los desarrolladores que inician su trabajo en la modalidad de teletrabajo, y que no tengan este proceso definido, mejoren la forma de realizar los desarrollos. Tradicionalmente, un profesional de software, al incursionarse en el modo del teletrabajo, está ausente de un entorno laboral usual y se somete a sus propias maneras de llevar a cabo un desarrollo, por lo cual, se puede presentar que el profesional no tenga un proceso específico para desarrollar software o que no conozca alguno en particular. La propuesta en este artículo se enfoca en brindar una mejora para que pueda tener un proceso software base por el cual pueda abordar los retos particulares del teletrabajo.
Does higher longevity harm economic growth?
Authors: Sirag Abdalla , Nor Norashidah , Law Siong
Published: September 2019

This study contributes to economic growth literature by providing new evidence on the relationship between life expectancy and economic growth utilising the recently developed dynamic panel threshold estimator. The sample of this study contains a total of 112 developed and developing countries covering the period from 1981 to 2010. The findings indicate the existence of a non-linear relationship between life expectancy and economic growth. In particular, life expectancy is useful for economic growth but only up to a certain threshold level; any further increase in longevity above the threshold would adversely affect growth. These findings emphasise the role of demographic transition in explaining the relationship between health and economic growth.
Reduction in Glycated Hemoglobin and Daily Insulin Dose Alongside Circadian Clock Upregulation in Patients With Type 2 Diabetes Consuming a Three-Meal Diet: A Randomized Clinical Trial
Authors: Jakubowicz Daniela , Landau Zohar , Tsameret Shani , Wainstein Julio , Raz Itamar , Ahren Bo , Chapnik Nava , Barnea Maayan , Ganz Tali , Menaged Miriam , Mor Naomi , Bar-Dayan Yosefa , Froy Oren
Published: September 2019

OBJECTIVE

In type 2 diabetes, insulin resistance and progressive β-cell failure require treatment with high insulin doses, leading to weight gain. Our aim was to study whether a three-meal diet (3Mdiet) with a carbohydrate-rich breakfast may upregulate clock gene expression and, as a result, allow dose reduction of insulin, leading to weight loss and better glycemic control compared with an isocaloric six-meal diet (6Mdiet).

RESEARCH DESIGN AND METHODS

Twenty-eight volunteers with diabetes (BMI 32.4 ± 5.2 kg/m2 and HbA1c 8.1 ± 1.1% [64.5 ± 11.9 mmol/mol]) were randomly assigned to 3Mdiet or 6Mdiet. Body weight, glycemic control, continuous glucose monitoring (CGM), appetite, and clock gene expression were assessed at baseline, after 2 weeks, and after 12 weeks.

RESULTS

3Mdiet, but not 6Mdiet, led to a significant weight loss (−5.4 ± 0.9 kg) (P < 0.01) and decreased HbA1c (−12 mmol/mol [−1.2%]) (P < 0.0001) after 12 weeks. Fasting glucose and daily and nocturnal glucose levels were significantly lower on the 3Mdiet. CGM showed a significant decrease in the time spent in hyperglycemia only on the 3Mdiet. Total daily insulin dose was significantly reduced by 26 ± 7 units only on the 3Mdiet. There was a significant decrease in the hunger and cravings only in the 3Mdiet group. Clock genes exhibited oscillation, increased expression, and higher amplitude on the 3Mdiet compared with the 6Mdiet.

CONCLUSIONS

A 3Mdiet, in contrast to an isocaloric 6Mdiet, leads to weight loss and significant reduction in HbA1c, appetite, and overall glycemia, with a decrease in daily insulin. Upregulation of clock genes seen in this diet intervention could contribute to the improved glucose metabolism.
Improving the Quality of Human Resources in Indigenous Village Institutions Through Work Culture Based on "Catur Marga" in Bali Aga Village, Buleleng Regency
Authors: Ningsih Luh Kartika , Yudi Prastiwi Ni Luh Putu Eka
Published: September 2019

This study aims to determine the improvement of human resources quality of the Village Institution through Catur Marga-based Work Culture in Bali Aga Village, Buleleng Regency. A quantitative approach will be used in this study. The data analysis technique used in this study was SEM PLS Version 3.0. The sample is 135 people with t-table values for the significance level α = 0.05 of 1.960. The results showed that there was a positive and significant result in all relationships where the Effect of Catur Marga-based Work Culture on HRM was 4.477. Likewise, the Effect of Catur Marga-based Work Culture on Work Productivity was 31.010, and the relationship of Human Resource Management to Work Productivity was 7.338. From the results, it can be concluded that Catur Marga- based culture work has a positive role because it can provide good results for improving the Quality of Human Resource Management and Work Productivity.
Makna Stylish di Kalangan Mahasiswa Universitas Negeri Padang
Authors: Oktialista Yovi , Erianjoni Erianjoni
Published: September 2019

Penelitian ini bertujuan untuk mengetahui makna stylish di kalangan mahasiswa Universitas Negeri Padang yang memeiliki berbagai kriteria penampilan stylish ketika ke kampus. Teori yang digunakan untuk menganalisis penelitian ini ialah teori interaksionisme simbolik yang dikemukakan oleh Herbert Blumer yaitu interaksi individu menggunakan simbol-simbol dan memiliki makna. Metode yang digunakan dalam penelitian ini ialah pendekatan kualitatif yang bersifat deskriptif dengan jenis penelitian studi kasus serta teknik pemilihan informan purposive sampling. Dalam pengumpulan data dilakukan dengan cara observasi, wawancara, dan dokumentasi dengan teknik analisis data dari Miles dan Huberman. Hasil penelitian ini menemukan bahwa makna stylish di kalangan mahasiswa UNP terdapat 3 makna yaitu, (1). Makna percaya diri; (2). Makana keren dan; (3). Makna daya tarik. Kriteria stylish yang sering digunakan mahasiswa UNP adalah pakaian dengan style casual.