bluuebunny/crossref_metadata_2025 huggingface dataset:
Une expérience pédagogique musicale en Grande Section Maternelle et Cours Préparatoire
Authors: Guilloret Marie-Renée
Published: June 2021

Au cours d’une expérience pédagogique menée en Grande Section Maternelle et en Cours Préparatoire, les élèves ont composé leurs propres musiques. Mon interrogation porte sur la nature des processus mobilisés. Je me réfère à la conception vygotskienne selon laquelle la culture serait le foyer de zones proximales de développement, permettant à un apprenant d’agir avec un autre plus expert. Ce qui me guide vers l’identification de processus de recours aux ressources. Je repère alors comment les élèves font appel aux musiciens, à leurs pairs, et plus largement aux ressources du dispositif. Puis je prends en compte le décalage entre intention, ressources et production finalisée, jusqu’à formaliser la mise en œuvre de processus d’ajustement. Ces processus sont présentés comme les indicateurs d’une dynamique créative, opérant dans un dispositif qui favorise la mutualisation des ressources et leur appropriation mutuelle.
La mère, la directrice, la pédagogue et la lectrice : de l’utilisation du sexe comme variable pédagogique chez Pauline Kergomard
Authors: Kolly Bérengère
Published: June 2021

L’éducation maternelle dans l’école témoigne d’une proposition pédagogique nouvelle entendant puiser au sein de la famille, auprès des gestes maternels et des habitudes domestiques, des principes nouveaux pour l’école des tout-petits. Pauline Kergomard prend ainsi acte d’une circulation nécessaire entre famille et école, tout en établissant différenciation entre modèle réel et modèle philosophique : c’est en distance avec la mère réelle, mais ancrée dans le « génie maternel » que la directrice construit un type d’école nouveau. Cette distorsion entre réel et imaginaire révèle une particularité dans l’utilisation du sexe féminin, ici comme variable pédagogique. L’appartenance au sexe féminin de la mère, de la directrice, de la pédagogue elle-même et de ses lectrices, parce que comprise comme une variable historique et non biologique, peut ainsi devenir un levier d’innovation et de création, dans les conceptions et les pratiques pédagogiques.
Review article on Alternanthera philoxeroides (Mart.) Griseb (alligator weed); an invasive plant species in Sri Lanka and its control measures
Authors: Dissanayake N. P.
Published: June 2021

Alligator weed (Alternanthera philoxeroides (Mart.) Griseb) is an invasive weed in different countries of South America, North America, Australia and Asia. It can grow in range of habitats from aquatic to terrestrial environments. It is one of the non- native plants which was invading natural and agricultural eco systems in Sri Lanka and has recorded as a threat to the native species and thereby to the plant bio diversity. It was an accidental introduction to Sri Lanka due to misidentification as a commonly cultivated leafy vegetable A. sessilis (Mukunuwenna). So it is highly possible to include A. philoxeroides in the market samples of leafy vegetables due to this similarity. A. philoxeroides can propagate through vegetative fragmentation and these vegetative propagules can be dispersed by water in aquatic habitats. An over view of all aspects of A. philoxeroides including its geographical distribution and spread in the world, morphology and ecological aspects, environmental impacts, success of the management options used and present status of this weed in Sri Lanka is presented by this article. Management of alligator weed through chemical, biological, and mechanical means are effective up to some extent in Sri Lanka but it is still a problem in many areas Therefore well-planned, long-term mechanism to evaluate the role of different factors which is responsible for rapid infestation is essential to control the weed. Future research should be focused more on integration weed management approaches in both natural and agricultural ecosystems and to identify the weed from its congener, A. sessilis.
Sustainability and Well-being in Geriatrics: proposing a performance-based approach for the implementation of geriatric care activities
Authors: Mazza Liliana , Ievoli Riccardo
Published: June 2021

The evaluation and measurement of Sustainable Development and Well-being represent a widespread emerging theme in healthcare, especially concerning, among others, the concepts of social equity and universality of health from an intergenerational perspective. To achieve such goals, Geriatrics would play a prominent role, especially considering the growing portion of the senior population in developed countries. This work intends to explore the possibility to connect Sustainable Development Goals and dimensions of Well-being to a set of performance indicators which are representative of geriatric activities in different settings of care. To this purpose, a pattern of indicators from Emilia- Romagna Region (RER) in Italy is considered. Furthermore, a range of Transitional Care interventions is discussed and proposed in order to ameliorate (or keep stable) the performance.
Scopoletin and Umbelliferone from Cortex Mori as Protective Agents in High Glucose-Induced Mesangial Cell as in vitro Model of Diabetic Glomerulosclerosis
Authors: Liang Yijun , Zeng Xuxin , Guo Jialiang , Liu Hui , He Bao , Lai Renyu , Zhu Quan , Zheng Zhaoguang
Published: June 2021

Two known coumarins, scopoletin (SP) and umbelliferone (UB), were isolated from Cortex Mori (CM). Their structures were elucidated by various spectroscopic analyses. Then, their effects on rat glomerular mesangial cells (RGMCs, HBZY-1) proliferation, hypertrophy, extracellular matrix (ECM) proliferation, expression of fibronectin, transforming growth factor-beta (TGF-β), and connective tissue growth factor (CTGF) induced by high glucose were studied in vitro model of diabetic glomerulosclerosis. The results show that, CM, SP, and UB can inhibit the RGMCs proliferation to attenuate the ECM proliferation and cell hypertrophy, reduced the accumulation of ECM protein fibronectin, and lowered the expression of the key fibrosis factor TGF-β and CTGF to inhibit the kidney fibrosis and thereby improved diabetic glomerulosclerosis. The two coumarins show great potentialities on treating diabetic glomerulosclerosis, but the animal experiment and mechanism is strongly needed for further proof.
Facile Synthesis of a Pt(IV) Prodrug of Cisplatin and Its Intrinsically 195mPt Labeled Analog
Authors: Sharma K. Shitaljit , Vimalnath K. V. , Phadnis Prasad P. , Chakravarty Rubel , Chakraborty Sudipta , Dash Ashutosh , Vatsa Rajesh K.
Published: June 2021

Background, Aims and Objectives:

Cisplatin is extensively used in chemotherapy for treatment of a broad range of cancers. But its undesired side reactions with biomolecules that lead to severe side effects especially on kidney and nervous system, are limiting its clinical utility. To reduce its side effects, the kinetically inert Pt(IV) prodrug was recognized as an alternative approach from satisfactory results of preliminary experiments. But, its approval as anticancer drug for clinical use requires detailed investigations of its anticancer action and pharmacological pathways by employing its analogue which can be traced by a suitable technique. As a step closer towards translation of Pt(IV)-based prodrug from research to clinical level, a protocol for efficient synthesis of 195mPt-radiolabeled Pt(IV) prodrug was devised.

Materials and Methods:

In order to achieve the aim, we started synthesis from elemental platinum avoiding lengthy steps. The synthesis protocol was standardized on its cold analogue, as [PtCl2(NH3)2(OCOCH2CH2COOH)2] which has been characterized with nuclear magnetic resonance (1H, 13C{1H} and 195Pt{1H}) spectroscopy, microanalyses and cyclic voltammetry. Also, cytotoxicity of [PtCl2(OCOCH2CH2COOH)2(NH3)2] was evaluated against MCF-7 human breast cancer cell lines using cisplatin as test control.

Results:

Intrinsically, 195mPt-labeled analogue of prodrug was obtained with high radionuclidic and radiochemical purity. It was confirmed by chromatography and γ-ray spectrometry.

Conclusion:

The 195mPt-radiolabeled prodrug was synthesized in a facile manner. It can be utilized in evaluating the mechanism of anticancer action and pharmacokinetics by enabling synergistic use of molecular imaging and targeted drug delivery.
Renal Cell Carcinoma Mimicking with Peritoneal Carcinomatosis and Krukenberg Tumor
Authors: Kumar Navin , Lata Kanak , Tripathy Sarthak , Shamim Shamim Ahmed , Ray Mukur Dipi
Published: June 2021

Krukenberg tumor (KT) is a rare clinical entity with a mysterious origin. It originates most commonly from adenocarcinoma of the stomach. We present an interestingly rare case of this entity in renal cell carcinoma, revealed by 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) scan. Ovarian cancers with diffuse peritoneal metastasis were considered the differential diagnosis of the disease, based on PET/CT. The potential efficacy of this functional imaging for KT is still in the exploratory phase, but its applications in diagnosis, disease prognostication, therapeutic response monitoring, and follow-up recurrence detection are superior than other imaging modalities.
In-House Preparation and Quality Control of Ac-225 Prostate-Specific Membrane Antigen-617 for the Targeted Alpha Therapy of Castration-Resistant Prostate Carcinoma
Authors: Thakral Parul , Simecek Jakub , Marx Sebastian , Kumari Jyotsna , Pant Vineet , Sen Ishita Barat
Published: June 2021

Purpose:

Ac-225 labeled with prostate-specific membrane antigen (PSMA-617), a transmembrane glycoprotein which is highly expressed in prostate carcinoma cells, is presently being considered a promising agent of targeted alpha therapy for the treatment of patients suffering from metastatic castration-resistant prostate cancer. In the present study, we report an optimized protocol for the preparation of therapeutic dose of Ac-225 PSMA-617 with high yield and radiochemical purity (RCP).

Methods:

Ac-225 PSMA-617 was prepared by adding the peptidic precursor-PSMA-617 (molar ratios, Ac-225: PSMA-617 = 30:1) in 1 ml ascorbate buffer to Ac-225 and heating the reaction mixture at 90°C for 25 min to obtain the radiopeptide with high RCP and yield. The radiolabeled peptide was administered in patients who met the eligibility criteria and posttherapy assessment was done.

Results:

Ten batches of Ac-225 PSMA-617 were prepared following this protocol. The radiopeptide was obtained with an adequate yield of 85%–87% and RCP of 97%–99%.

Conclusion:

The current protocol allows single-step, successful, routine inhouse radiolabeling of Ac-225 with PSMA-617 with high yield and RCP.
IgG4 Related Kidney Disease with Extra-Renal Involvement Demonstrated on FDG PET/CT
Authors: Chandra Piyush , Nath Satish
Published: June 2021

Immunoglobulin G4 (IgG4)-related kidney disease is a relatively rare clinical entity and usually occurs as an extra-pancreatic manifestation of IgG4-related autoimmune pancreatitis. We describe here the imaging findings of a patient who presented with recurrent multiorgan IgG4-related disease, involving bilateral kidneys/ureters, proximal small bowel, and multiple abdominal and extra-abdominal lymph nodes.
Advantage of Hybrid 18F-Fluoride Positron Emission Tomography/Computed Tomography to Diagnose Malignant Rib Invasion by Pleural Metastasis in a Background of Reactive Periostitis
Authors: Santhosh Sampath , Jeeva Godwin
Published: June 2021

Diffuse osteoblastic activity in the ribs on bone scan is seen in association with pleural thickening. Irrespective of the pleural pathology, this represents benign finding caused by pleural hyperemia or reactive periostitis, with preserved cortical integrity. However, malignant involvement of the ribs can occur by local invasion of pleural malignancy causing cortical lysis. Herein, we describe the 18F-fluoride positron emission tomography/computed tomography findings of reactive periostitis of the ribs in pleural metastasis and emphasize the advantage of hybrid imaging in detecting local malignant tumor invasion superimposed in such condition.
Metastatic Thyroid Cartilage Lesion from Prostatic Adenocarcinoma on 68Ga-Prostate-Specific Membrane Antigen Positron Emission Tomography-Computed Tomography Scan
Authors: Gupta Nitin , Verma Ritu , Belho Ethel Shangne
Published: June 2021

Prostate cancer usually metastasizes to regional lymph nodes and bone. Laryngeal cartilage metastases are very rare and only few cases have been published so far describing thyroid cartilage metastatic lesions from prostate cancer. Here, we describe 5 cases of carcinoma prostate, 3 staging and 2 follow-up, where 68Ga-prostate-specific membrane antigen positron emission tomography/computed tomography (PET/CT) scan revealed multiple skeletal lesions along with thyroid cartilage metastasis. Initially, laryngeal cartilage metastases remain asymptomatic and in later stages patients present with symptoms. These metastatic lesions to thyroid cartilage are rare entities and can often easily be missed on conventional imaging. PET-CT imaging has overcome this diagnostic problem due to its ability to provide for both anatomical and functional imaging.
Myeloid Sarcoma of the Prostatic Tissue Diagnosed on 18F-FDG PET/CT in Treated Case of Acute Myeloid Leukemia
Authors: Gosavi Atul Yashwant , Puranik Ameya , Agrawal Archi , Purandare Nilendu C , Shah Sneha , Rangarajan Venkatesh , Thomas Ann
Published: June 2021

Myeloid sarcoma is a rare extramedullary manifestation of acute myeloid leukemia (AML) that often presents during remission or disease relapse. The most common site of relapse being, however, many rare sites has been reported in the existing literature. We are herewith presenting the case of a 27-year-old patient of AML who showed an unusual site of relapse on fluorodeoxyglucose positron emission tomography/computed tomography scan.
Critical appraisal of journal article by psychiatry PG residents using a new module
Authors: Bhat Pookala Shivaram , Chail Amit , Srivastava Kalpana
Published: June 2021

Background:

A gap exists from evidence-based medicine (EBM) to clinical practice and there is a felt need to bridge this. Critical appraisal of scientific articles during Journal club by postgraduate (PG) residents will help them to understand and apply the scientific evidence into best clinical practice. Hence, a new module of critical appraisal of journal articles was used for Psychiatry Residents in a Medical College and its impact was assessed.

Materials and Methods:

Nine psychiatry PG residents from three academic batches participated in the study after informed consent and Institutional ethical committee clearance. They were trained in the Colorado Psychiatry EBM Examination Test module. Subsequently, three consecutive journal article presentations of them were assessed under seven Subtests of the module.

Results:

There was gradual increase in the assessment scores of all PG residents with each journal article presentation. They also expressed satisfaction of the assessment method and felt confident of applying the principles of critical appraisal in their clinical practice in future.

Conclusion:

This study evaluated the impact of a new module of critical appraisal of journal article by psychiatry PG residents. It was found to be acceptable by residents and improved their competency to apply literature-based EBM into their clinical practice. It is recommended for further multicentric evaluation on a larger sample.
Psychiatric morbidity in patients with idiopathic Parkinson's disease
Authors: Kumar Santhosh , Avasthi Ajit , Modi Manish , Grover Sandeep
Published: June 2021

Objective:

To evaluate the prevalence of psychiatric comorbidities in patients with idiopathic Parkinson's disease (IPD).

Methodology:

Two hundred and thirty-nine patients with IPD were evaluated on Mini-International Neuropsychiatric Interview PLUS (MINI-PLUS). In addition, patients found to have depression as per the MINI-PLUS were evaluated on Beck Depression Inventory.

Results:

One hundred and thirty-five (56.5%) patients had a current psychiatric diagnosis and 59.8% had a lifetime psychiatric diagnosis. As per MINI-PLUS, about two-fifth (39.7%) of patients had suicidality. In 18.8% of patients, suicidality was present in the absence of axis-I psychiatric diagnosis. Among the various psychiatric disorders, the most common disorders included depressive disorders (current: 17.5%; lifetime: 23.8%), anxiety disorders (current: 17.5%; lifetime: 17.5%), and psychotic disorders (current: 11.3%; lifetime: 11.7%).

Conclusions:

More than half of the patients with Parkinson's disease have psychiatric disorders. High prevalence of psychiatric morbidity calls for close liaison between the neurologist and the psychiatric disorders.
A Case of Extrapulmonary Tuberculosis Presenting as Multiple Pleural Nodules and Esophageal Ulcer
Authors: Chakkamadathil Jesin Kumar , Chetambath Ravindran , Shivashankaran Sanjeev , Girija C. , Mathew Christopher
Published: June 2021

Tuberculosis (TB) can affect various organs besides the lungs. Among the extrapulmonary sites, pleura and gastrointestinal tract are the second- and sixth-most common sites, respectively. Pleural involvement usually occurs in the form of pleural effusion, and the sites most commonly involved in gastrointestinal TB are the peritoneum and ileocecal area. Here we present an interesting case of a 23-year-old female who presented to the gastroenterologist with symptoms of dysphagia, regurgitation of food, and weight loss. Esophagogastro duodenoscopy showed an esophageal ulcer which was confirmed to be due to TB. Incidentally, this patient also had multiple pleural nodules due to TB. This case is unique since there is a simultaneous occurrence of two different sites of occurrence of extrapulmonary TB.
Association of Pattern of Mandibular Invasion in MDCT with Recurrence in Oral Cancers
Authors: Thakker Vishal , Arora Manali , Thakkar Nisarg
Published: June 2021

Background:

Mandibular invasion has been a long-debated criterion for predicting prognosis in oral cancers. Though the American Joint Committee on Cancer (AJCC) marks cortical erosion in oral lesions as T4 disease, it is often challenged that mere superficial bony erosion should not be used to demark T4 disease.

Aim:

This study aimed to evaluate the association of pattern of mandibular erosion in preoperative Multi-Detector CT (MDCT) of oral cancers with the presence of recurrent loco-regional malignant disease.

Materials and Methods:

A retrospective study was done in the Department of Radio-Diagnosis of a tertiary center in Western India. MDCT Neck findings in 56 consecutive postoperative patients clinically suspected for recurrent oral carcinoma over a period of 1 year were assessed. Preoperative MDCT of all patients was evaluated for presence and pattern of mandibular involvement by primary malignancy. These patterns were compared with the presence of recurrent disease in the postoperative scan. Association between two findings was tested by Fisher's exact test.

Results:

Forty-eight patients showed features of recurrent malignancy on MDCT confirmed by biopsy; of which 10 patients had shown no bony invasion in the preoperative scan, 14 had shown cortical erosion and 24 showed medullary invasion. P value for association of recurrence and bony invasion pattern was found to be 0.6705 (insignificant) for cortical erosive lesions and 0.0469 (significant) for medullary infiltrative lesions.

Conclusion:

Only medullary infiltrative lesions of the mandible have a statistically significant association with recurrent disease and may be used as a prognostic factor. Cortical erosions are statistically insignificant in predicting recurrence similar to no bone invasions.
Analysis of Fractal Dimension and Radiomorphometric Indices of Mandible on Panoramic Radiographs in End-Stage Renal Disease at a Tertiary Care Centre in South India
Authors: Redhu Anju , Suman B.
Published: June 2021

Background and Objectives:

Chronic kidney disease (CKD), especially, end-stage renal disease (ESRD), is associated with endocrinal and metabolic alterations that negatively affect the skeletal system, and can result in renal osteodystrophy (ROD) and secondary osteoporosis. These changes can affect the mandibular density and thus can be reflected in mandible on panoramic radiographs (PR), which are frequently assessed by oral physicians. This study attempted to evaluate these mandibular skeletal alterations using radiomorphometric indices (RI) and fractal dimension (FD) analysis, in patients with ESRD, thereby aiding in their appropriate management for the dental treatment.

Material and Methods:

Retrospective data (including digital PRs) of 30 patients with CKD (ESRD) who were above 18 years of age were retrieved and 30 age and sex-matched healthy individuals having met the selection criteria were selected. Digital PR were used to assess the mandibular cortical index (MCI), mental index (MI), panoramic mandibular index (PMI), and FD by using ImageJ program.

Results:

No statistically significant difference was noted among the study groups and controls for the mean values of PMI, FD, and distribution of MCI category (P > 0.05). However, the mean value of MI was significantly reduced among the kidney patients as compared to the controls (P < 0.05). No significant correlation was noted between duration of diseases, RI (MCI, MI, PMI) and FD.

Conclusion:

MI values of patients with ESRD were found to be lower than those in control subjects. This finding suggests that MI analysis might be a promising, simple, and cost-effective tool for evaluating cortical bone structure in this high-risk population and any signs of osteoporosis could be withheld at the earliest stage with a prompt referral.
Comparative Evaluation of the Efficacy of Gabapentin and Gabapentin in Combination with Nortriptyline in the Management of Pain-Related Temporomandibular Disorders
Authors: Tak Mohsin Muzaffar , Chalkoo Altaf Hussain , Bhat Tariq Ahmad , Jan Tauseefa
Published: June 2021

Background:

Temporomandibular disorders (TMDs) are considered the most common orofacial pain conditions of nonodontogenic origin. The current perspective regarding TMD is multidimensional. If the pain becomes chronic, it can have a great impact on the social and emotional behavior of the patient.

Materials and Methods:

A total of 40 patients between the age groups of 18 and 45 years were included in the study. These patients were divided into two groups comprising 20 patients each. Group I was prescribed gabapentin and was advised to take the medicine twice daily. Group II was prescribed gabapentin along with nortryptyline twice daily. Patients in each group were evaluated at the end of every week using a visual analog scale (VAS) score for pain, maximum interincisal mouth opening, and several muscle tenderness sites for 3 weeks, and a comparison was made.

Results:

The age range in group I was 19–45 years, whereas in group II it was 18–45 years with a P value of 0.711. Female predominance was observed in both groups as 65% of patients were females in group I and 60% were females in group II and P value obtained was 0.74. VAS score decreased more rapidly in group II than group I. The P value obtained was <0.001 at the end of the third week. Comfortable moth opening shows a more effective increase in group II than group I. The P value (0.003) shows significance at the end of the third week. The mean number of muscle tenderness sites at the end of 3 weeks in group I and group II reduced to 1.15 and 0.40, respectively.

Conclusion:

The combination therapy of gabapentin with nortryptyline was found to be more effective than gabapentin alone.
Pneumosinus Dilatans
Authors: Ramani Priya , Nithya V. R. , SreeDevi J. , Vinod Kumar A. C.
Published: June 2021

Pneumosinus dilatans is a rare entity that is documented only by a few reports. It is an abnormal expansion of the aerated frontal sinus, with sinus walls of normal thickness. The bone expansion is focal. A case was reported in our dental college; a 28-year-old male complaining of prominence on his forehead and it has an unknown cause and no functional problems. Computed tomography shows extension pneumatization and expansion of frontal sinus, which is extended from one side of the skull to the other side. It is benign and found to be asymptomatic. No evidence of pathological changes and no bone destruction seen. We discuss this case of etiology, clinical features, and radiological features.
Effect of mobile voice calls on treatment initiation among patients diagnosed with tuberculosis in a tertiary care hospital of Puducherry
Authors: Majella MG , Thekkur P , Kumar AM , Chinnakali P , Saka VK , Roy G
Published: June 2021

Objective:

In India, about one third of tuberculosis (TB) patients diagnosed at tertiary hospitals are missed during a referral to peripheral health institutes for treatment. To address this, we assessed whether mobile voice call reminders to TB patients after diagnosis at a tertiary hospital decrease the proportion of “pretreatment loss to follow-up” (PTLFU), compared with the conventional paper-based referral.

Design:

A two-group parallel-arm randomized controlled trial was conducted.

Setting:

The study was conducted in a tertiary care hospital at Puducherry, South India.

Participants:

All newly diagnosed TB patients, both pulmonary and extrapulmonary, who were referred for treatment from the selected tertiary care hospital and possessed a mobile phone were eligible to participate. The participants were enrolled between March 2015 and June 2016 and were randomized to study groups using the block randomization with allocation concealment.

Intervention:

The participants in the intervention arm received standardized mobile voice calls reminding them to register for anti-TB treatment on the second and seventh day after referral in addition to the conventional paper-based referral received by the control group.

Primary outcomes:

Patients not started on anti-TB treatment within 14 days of referral were considered as PTLFU. The outcome of PTLFU was ascertained through phone calls made on the 14th day after referral. The intention-to-treat analysis was used, and the proportion of PTLFU in the study groups and the risk difference with 95% confidence interval (CI) were calculated.

Results:

Of the 393 patients assessed for eligibility, 310 were randomized to the intervention (n = 155) and control (n = 155) arms. In the intervention arm, 14 (9%) out of 155 were PTLFU compared with 28 (18%) of the 155 patients in the control arm. The absolute risk difference was 9% (95% CI [1.5, 16.6], P = 0.01).

Conclusion:

Mobile voice call reminder to patients is a feasible intervention and can reduce PTLFU among referred TB patients.
Severe Combined Immunodeficiency
Authors: Sinha Sajan , Nandi Sayantani , Das Mrinal Kanti , Basu Suprit
Published: June 2021

5 month old female baby presented with cough followed by respiratory distress and not gaining weight. There was no history of fever, diarrhea or recurrent infections. Her elder brother died due to respiratory illness at the age of 8 months. There was accelerated reaction at BCG site. Repeated peripheral blood examination showed absolute lymphopenia. Thymus shadow was absent in X-ray. Patient was evaluated and diagnosed as Severe combined immune deficiency (T-, B+, NK-).
Severe Thrombocytopenia from Acute Levamisole Toxicity in a Nigerian child
Authors: Daniel Apollos , Garba Nuhu Abubakar , Ahmadu Ibrahim , Abubakar Muhammad shakur , Yejide Opeyemi Jegede , Obiagwu Patience , Asani Mustafa O. , Aliyu Ibrahim
Published: June 2021

Levamisole-induced thrombocytopenia and vasculitis are rare entities in children. Here, we report a 5-year-old male who presented with complaints of purpuric rashes and nasal and gum bleeding for 24 h following intake of single high-dose levamisole for presumptive treatment of helminthiasis. No preceding symptoms of viral infection or bleeding into closed spaces were noted. He was clinically stable except for maculopapular and patchy purpuric rashes on the face, neck, and trunk. No hepatosplenomegaly or lymphadenopathy was observed. Full blood count and blood film showed severe thrombocytopenia of 6.00 × 109/L and platelets left shift with dysplastic neutrophils. He was commenced on prednisolone and transfused with fresh whole blood. The patient improved remarkably and showed reversal of hematological parameters within 48 h. Further, full blood count examination showed reactive thrombocytosis. Levamisole induces reversible thrombocytopenia by immune-mediated cytotoxic destruction of the platelets and white blood cells.
Donath-Landsteiner Hemolytic Anemia with Erythrophagocytosis and Platelet Phagocytosis in Peripheral Smear
Authors: Basit Momin Majed Abdul , Aluri Anamika , Bhaskar P. M. Bala
Published: June 2021

The Donath-Landsteiner (DL) hemolytic anemia or paroxysmal cold hemoglobinuria (PCH) is a rare subtype of autoimmune hemolytic anemia (AIHA). We report here a case of a 22-year-old young female who presented with acute onset shortness of breath. Routine hematological investigation revealed erythrophagocytosis and platelet phagocytosis by monocytes in peripheral blood smear, which are rarely reported in AIHA, especially the DL. The unusual blood smear findings directed the pathologists to initiate workup for hemolytic anemia that yielded positive results in direct Coombs test C3d (Complement) and direct DL test. The findings confirmed the case as DL hemolytic anemia. To the best of our knowledge, this is the first report of both erythrophagocytosis and platelet phagocytosis in peripheral blood smear in PCH.
Radiation-Induced Ocular Surface Disorders and Retinopathy: Ocular Structures and Radiation Dose-Volume Effect
Authors: Akagunduz Ozlem Ozkaya , Yilmaz Suzan Guven , Tavlayan Emin , Baris Mine Esen , Afrashi Filiz , Esassolak Mustafa
Published: June 2021

Purpose This study aimed to evaluate the radiation-induced adverse effects on ocular structures in head and neck cancer patients and investigate the radiation dose-volume effects on the cornea, lacrimal gland, retina, optic nerve and chiasm.Materials and Methods A total of 38 eyes of 19 patients were included in this prospective, cohort study. All patients underwent complete ophthalmological examination in addition to contrast sensitivity, visual field and visual evoked potentials (VEP) tests. Ophthalmological examinations and psychophysical tests were performed in 6th, 12th, 18th, 24th months and in the last visit. The relationship between the ophthalmologic findings, and the radiation doses below and above the cut-off values was evaluated.Results Contrast sensitivity decrease and visual field deterioration were observed in 42% of the patients in the last visit (median 26 months) whereas a prolonged latency and decreased amplitude of P100 wave in VEP was observed in 58% and 33% of the eyes, respectively at 24th month. Totally 16 patients (84.2%) developed dry eye disease and eight of them received radiotherapy below tolerance doses and had mild to moderate dry eye findings. Radiation-induced retinopathy was observed in three of the eyes in eight patients who received radiation above tolerance dose.Conclusion Head and neck cancers treated with radiotherapy, resulted in various ophthalmic complications. All patients who are treating with radiotherapy should be evaluated by an ophthalmologist in terms of anterior and posterior segment damage, even if the radiation dose is below the tolerance limit.
Complex interpolation of Besov-type spaces on domains
Authors: Zhuo Ciqiang
Published: June 2021

Let

\Omega\subset\mathbb{R}^d

(

d\geq 2

) be a bounded Lipschitz domain. In this article, the author mainly studies complex interpolation of Besov-type spaces on the domain

\Omega

, namely, we investigate the interpolation

[B_{p_0,q_0}^{s_0,\tau_0}(\Omega),B_{p_1,q_1}^{s_1,\tau_1}(\Omega)]_\Theta = B_{p,q}^{\diamond s,\tau}(\Omega)

under certain conditions on the parameters, where

B_{p,q}^{\diamond s,\tau}(\Omega)

denotes the so-called diamond space associated with the Besov-type space. To this end, we first establish the equivalent characterization of the diamond space

B_{p,q}^{\diamond s,\tau}(\mathbb{R}^d)

in terms of Littlewood–Paley decomposition and differences. Via some examples, we also show that this interpolation result does not hold under some other assumptions on the parameters or when

\Omega=\mathbb{R}^d

.
Heavy Metal Loading in Surface Sediments along the Kawere Stream, Tarkwa, Ghana
Authors: Ndur S. A. , Nyarko S. Y. , Quaicoe I. , Osei L. B.
Published: June 2021

Sediment contamination by heavy metals resulting from anthropogenic activities is increasingly becoming a global concern due to the risk it poses to human well-being and ecological integrity at large. The purpose of this study was to assess the heavy metals loading in sediment along the Kawere stream. Ten sediment samples were collected, acid digested and analysed for copper (Cu), lead (Pb), cadmium (Cd), manganese (Mn), zinc (Zn), nickel (Ni), chromium (Cr), cobalt (Co) and iron (Fe) using a Varian AA240FS Atomic Absorption Spectrometer (AAS). The Australian and New Zealand Environment and Conservation Council (ANZECC) guidelines for freshwater sediment quality was used as the benchmark against which the measured metal concentrations were compared. Nemerow’s pollution and potential ecological risk indices were used to evaluate the pollution status and ecological risk levels of the heavy metals in the stream. The results obtained indicated that, except Cu which exceeded the ANZECC trigger value of 65 mg/kg at three sampling sites (K01=171.29 mg/kg, K05=170.83 mg/kg and K07=113.31 mg/kg), all other measured heavy metals concentrations were below their corresponding ANZECC values. Heavy metal pollution assessment showed that three samples (K01, K05 and K07) were slightly polluted, suggesting the likelihood of posing a health threat to the aquatic organisms and humans. Calculated Ecological Risk Index (RI) ranged from 3.229 to 19.750 (RI < 150), representing a low ecological risk. As such, the metals, Cu, Ni, Cd, Pb, Cr, and Zn pose a low ecological risk to the aquatic ecosystem. Although the ecological risk is low based on the current results, constant monitoring of the stream quality is recommended due to the increasing human activities along the stream as well as the sediments ability to accumulate and remobilise heavy metals back into the water column and possibly transferring them through the food chain.

 

Keywords: Heavy Metals, Sediment, Ecological Risk Assessment, Pollution, Stream
Dimensions of User Experience - from the Product Design Perspective
Authors: Bongard-Blanchy Kerstin , Bouchard Carole
Published: June 2021

The UX domain has so far been strongly associated with software development. However, its methods are finding their way intodomains like Product and Service Design. Product Designers now need competencies far beyond classical form-giving. The objective of thispaper is to show Product Designers which design dimensions they need to attend to when designing for UX. The paper gives an overview ofdesign dimensions that potentially impact how users’ experience products. These dimensions are brought together from theories ofCognitive Science, models of Human-Computer Interaction and findings from Design Research. They are presented under four categories:dimensions of human perception, dimensions of products, dimensions of the context of use and the temporal dimension. In the final part, theidentified dimensions are connected into a schema, illustrating their interplay and therefore the journey of UX between a user and a product,in a certain context over a certain time.

Le domaine EU (Expérience Utilisateur) a été étroitement lié au développement des logiciels. Les méthodes UX trouventcependant de plus en plus d’applications dans le Design de Produits. Aujourd’hui le Designer Produit doit mettre en oeuvre des compétencesqui vont bien au-delà de la seule définition de l’apparence. L’objet de cet article est de mettre en lumière ces dimensions du design que lesDesigners Produit soucieux de concevoir dans le respect de l’UX ne sauraient ignorer. L’article apporte ainsi une vue globale sur lesdimensions susceptibles d’impacter l’UX. L’identification des dimensions pertinentes puise à la fois dans les théories de la psychologiecognitive, dans les modèles d’interaction homme-machine, ainsi que dans les résultats de la recherche en design. Ces dimensions sontensuite regroupées sous quatre catégories : les dimensions de la perception humaine, du produit et du contexte de l’utilisation, ainsi que ladimension temporelle. Enfin, ces dimensions sont mises en relation dans un schéma qui illustre le cours de l’expérience entre un utilisateuret un produit, dans un contexte et avec sa temporalité.
Sandviç Kompozit ve Metal Plakalar ile Oluşturulan Tek Bindirmeli Yapıştırma Bağlantılarının Mekanik Özelliklerinin Deneysel ve Nümerik Yaklaşım ile Belirlenmesi
Authors: ERBAYRAK Engin
Published: June 2021

Bu çalışmada, farklı malzemeler kullanılarak oluşturulan tek bindirmeli yapıştırma bağlantılarının mekanik özellikleri deneysel ve nümerik yaklaşım ile belirlenmiştir. Tek bindirmeli yapıştırma bağlantılarında plaka malzemesi olarak çelik, alüminyum ve alüminyum sandviç kompozit malzeme, yapıştırıcı olarak ise Araldite 2015 epoksi yapıştırıcı kullanılmıştır. Aynı malzemeye sahip plakalar kullanılarak elde edilen yapıştırma bağlantılarının yanı sıra, farklı malzemelere sahip plakalardan oluşan yapıştırma bağlantıları da bu çalışma kapsamında incelenmiştir. Deneysel yaklaşımda çekme testleri 1 mm/dak çekme hızında gerçekleştirilmiştir. Deneysel yaklaşım sonunda her bir yapıştırma bağlantısının gerilme-birim şekil değiştirme grafikleri belirlenmiştir. Ayrıca, plaka malzemesi olarak kullanılan alüminyum sandviç kompozit malzeme de yer alan polietilen polimerinin XRD testi ile karakterizasyonu yapılmıştır. Nümerik yaklaşımda, deneysel yaklaşımda kullanılan tek bindirmeli yapıştırma bağlantı geometrisi Ansys sonlu elamanlar programında oluşturulmuştur. Model oluşturulurken yapıştırıcı ile plakalar arasında non-lineer kontak kurulmuş ve deney şartlarını karşılayan sınır şartları uygulanmıştır. Bindirme bağlantılarının non-lineer modellenmesi, doğru sınır koşullarının uygulanması ve doğru temas tipinin seçilmesi nedeniyle nümerik sonuçların deneysel sonuçlarla benzer bir eğilim gösterdiği görülmüştür.
Manajemen Emosi di Masa Pandemi
Authors: Jatmiko Bakhoh , Kawengian Sherly Ester E. , Kapoyos Kapoyos
Published: June 2021

Pandemi Covid-19 telah menggoncang peradaban manusia di abad ini. Hampir semua sektor kehidupan terdampak dan nyaris dilumpuhkan olehnya. Tak pelak, pandemi ini menghadirkan berbagai persoalan-persoalan kehidupan yang serius, termasuk bagi kejiwaan manusia. Berbagai riset yang telah dilakukan menemukan bahwa tingkat stres dan gangguan kejiwaan meningkat di masa pandemi ini. Oleh karena itu, kajian ini dilakukan untuk menemukan prinsip Alkitabiah tentang pengelolaan emosi yang diakibatkan oleh situasi sulit ini. Penulisan ini menggunakan metode kualitatif dengan pendekatan deskreptif yang berfokus pada kajian tektual dari Mazmur 56. Penulisan juga dilakukan dengan menggunakan berbagai literatur dan dokumen serta data pendukung. Kajian di dalam artikel ini menemukan bahwa persoalan emosi yang meningkat dapat diatasi ketika prinsip manajemen emosi yang dilakukan Daud juga diterapkan oleh orang percaya. Di dalam pengalaman bergumul emosi negatif  sebagai respon terhadap dituasi yang dihadapi, orang percaya perlu mengembangkan sikap jujur terhadap apa yang dirasakan, mengubah perspektif terhadap kesulitan dan mengembangkan sikap positif.
An Old/New Vision of Europe. National Responsibility and Cultural Otherness in Emine Sevgi Özdamar’s Play Perikizi
Authors: Pelloni Gabriella
Published: June 2021

Emine Sevgi Özdamar’s play Perikizi (2010) is a particularly significant migration story because of its shrewd exploration of European integration, specifically in Germany. The protagonist is a girl who undertakes an adventurous journey from Turkey to Europe in order to realize her dream of becoming an actress. The play thus delves into the problem of integration in Europe from both the internal and external perspective of a young woman from a country whose culture and history are deeply intertwined with Europe’s, but are exotic enough to represent the cultural ‘other’ in the eyes of every European. I focus on an issue that is a golden thread throughout the play: the connection between genocide, nationalism and xenophobia, a thematic complex told from the perspective of a character who discovers the chance for change on her journey from East to West. I demonstrate that Perikizi’s journey highlights some structural parallels between East and West with respect to these issues. The play opens up a space in which national responsibility and the relationship with cultural otherness are problematized through different aesthetic strategies. At the end, it depicts a vision of Europe that is an alternative to a past, and a present, of nationalist and racist crimes.
Migration Experiences in Selected Works by Stanislav Struhar
Authors: Šilhavá Gabriela
Published: June 2021

Stanislav Struhar, nowadays one of the most productive contemporary Austrian authors, has published 12 works so far. The main themes of his works include the integration of a migrant who loses and finds his home, the associated language change, the search for happiness in the new home or the conscious rejection of the traumatic past. This also corresponds to the fact that the main characters in almost all of his prosaic works are migrants or their descendants. Stanislav Struhar also shows that love and language are of particular importance for the integration of migrants into the foreign milieu. The article analyzes the ambivalent character of migration experiences and the positioning of migrants in foreign society using the example of the novels Das Manuskript (2002), Eine Suche nach Glück (2005) and the volume of short stories Fremde Frauen (2013). In the first work the main characters are confronted with physical violence, in other two works it is more about the migrants’ feelings of foreignness, stereotypes and prejudices, with which they are confronted. In this context, the attitude of the protagonists towards the language, both the foreign language and their mother tongue, should also be emphasized.
Medication review, polypharmacy and deprescribing: Results of a pilot scoping exercise in undergraduate and postgraduate education
Authors: Barnett Nina Lee , Jubraj Barry , Grant Daniel , Reddy Bhavana , Stevenson Jennifer M
Published: June 2021

Background: As part of tackling polypharmacy, effective medication review and safe deprescribing are key to World Health Organisation’s (WHO) 3rd Global Patient Safety Challenge. There is little information about whether this occurs consistently in pharmacy and medicine courses in England.
Objective: To create a snapshot of medication review, polypharmacy and deprescribing educational activity in a small number of university courses for medicines, pharmacy and non-medical prescribing.
Method: The authors undertook a pilot scoping exercise by emailing colleagues in schools of pharmacy and medicine across England about course inclusion of medication review and deprescribing. 11 universities, describing 17 programmes, responded (eight undergraduate pharmacy, four undergraduate medicine, four postgraduate medicine, one non-medical prescribing course). Data were categorised as: programme content, tools to support deprescribing, learning outcomes, and future intentions for deprescribing teaching.
Results: The results suggested variation in what was being taught.
Conclusion: In order to address both national and international agenda, the authors suggest that inclusion of training in this area and consistency of curricula are crucial to adequately equipping our future workforce to be fit for purpose.
Factors affecting academic self-efficacy and learning experiences of pharmacy students: Insights from a qualitative study in Zambia
Authors: Kalungia Aubrey Chichonyi , Chigunta Micheal , Sichone James , Apampa Bugewa , Marshall Sarah , May Claire , Mulundu Georgina , Mwila Chiluba , Banda Sekelani Stanley
Published: June 2021

Background: Factors influencing how pharmacy students learn and experience pharmaceutical education have not been elucidated in Zambia.      Aim: To elucidate contextual factors affecting academic self-efficacy and learning experiences among undergraduate pharmacy students at a public university in Zambia.     Methods: A qualitative study utilising focus group discussions was conducted at the University of Zambia. Thirty-two undergraduate pharmacy students participated in four focus group discussions. Qualitative data were thematically analysed.       Results: Four themes and eight sub-themes emerged from the data. Notional time management, learning style, and motivation; educational programme-related factors such as course load, the pace of teaching; the learning environment; and assessment practices affected undergraduate pharmacy students’ self-efficacy and learning experiences. Conclusion: Addressing the student-related, educational programme-related, and the learning environment factors identified in this study will contribute to the improvement of undergraduate pharmacy students’ learning experiences. This is premised to improve their educational outcomes and future practice of pharmaceutical care.
Driving Assistance System with Lane Change Detection
Authors: Sheu Jia-Shing , Tsai Chun-Kang , Wang Po-Tong
Published: June 2021

In this study, a simple technology for a self-driving system called “driver assistance system” is developed based on embedded image identification. The system consists of a camera, a Raspberry Pi board, and OpenCV. The camera is used to capture lane images, and the image noise is overcome through color space conversion, grayscale, Otsu thresholding, binarization, erosion, and dilation. Subsequently, two horizontal lines parallel to the X-axis with a fixed range and interval are used to detect left and right lane lines. The intersection points between the left and right lane lines and the two horizontal lines can be obtained, and can be used to calculate the slopes of the left and right lanes. Finally, the slope change of the left and right lanes and the offset of the lane intersection are determined to detect the deviation. When the angle of lanes changes drastically, the driver receives a deviation warning. The results of this study suggest that the proposed algorithm is 1.96 times faster than the conventional algorithm.
Design Philosophy for Buildings’ Comfort-Level Performance
Authors: Wariyatno Nanang Gunawan , Lie Han Ay , Hsiao Fu-Pei , Gan Buntara Sthenly
Published: June 2021

The data reported by Japan Meteorological Agency (JMA) show that the fatal casualties and severe injuries are due to heavy shaking during massive earthquakes. Current earthquake-resistant building standards do not include comfort-level performance. Hence, a new performance design philosophy is proposed in this research to evaluate the quantitative effect of earthquake-induced shaking in a building. The earthquake-induced response accelerations in a building are analysed, and the response accelerations related with the characteristic property of the building are used to evaluate the number of Seismic Intensity Level (SIL). To show the indispensability of the newly proposed comfort-level design philosophy, numerical simulations are conducted to evaluate the comfort level on different floors in a building. The results show that the evaluation of residents’ comfort levels should be considered in the current earthquake-resistant building design codes.