bluuebunny/crossref_metadata_2025 huggingface dataset:
Newer-generation antihistamines and the risk of adverse events in children: a systematic review
Authors: Miligkos Michael , Dakoutrou Maria , Statha Eleni , Theochari Nikoletta , Mavroeidi Ilektra Antonia , Pankozidou Ιoanna , Papaconstadopoulos Irene , Papadopoulos Nikolaos
Published: December 2020

Background: H1-antihistamines (AHs) are widely used for the treatment of
allergic diseases, being one of the most commonly prescribed classes of
medications in Pediatrics. Newer-generation AHs are associated with
fewer adverse effects compared to first-generation. However, their
relative harms in the pediatric population still need scrutiny. Methods:
We performed a systematic review of randomized controlled trials (RCTs)
which included comparisons of safety parameters between an orally
administered newer-generation AH with another AH (first- or second-
generation), montelukast or placebo in children aged≤12 years. We
searched MEDLINE and CENTRAL, independently extracted data on study
population, interventions, adverse events (AEs) and treatment
discontinuations, and assessed the methodological quality of the
included RCTs using the Cochrane’s risk of bias tool. Results:
Fourty-five RCTs published between 1989 and 2017 met eligibility
criteria. The majority of RCTs included school-aged children with
allergic rhinitis and had a follow-up period of up to a month. Four RCTs
reported serious AEs in patients receiving a newer-generation AH, but
only two patients experienced a possibly drug-related serious AE. The
occurrence of AEs, drug-related AEs and treatment discontinuations due
to AEs varied between RCTs. Most AEs reported were of mild intensity.
Indirect evidence indicates that cetirizine is more sedating than the
other newer-generation AHs. Conclusion: Our findings confirm that
newer-generation AHs have a favorable safety and tolerability profile.
However, we could not draw firm conclusions regarding the comparative
safety profile of the newer-generation AHs due to the paucity of
head-to-head RCTs, variation in definitions and reporting of AEs, and
short follow-up duration.
Innate and Adaptive Immune Responses to SARS-CoV-2 in Humans: Relevance to Acquired Immunity and Vaccine Responses
Authors: Jordan Stanley
Published: December 2020

The factors responsible for the spectrum of COVID-19 disease severity
and the genesis and nature of protective immunity against COVID-19
remain elusive. Multiple studies have investigated the immune responses
to COVID 19 in various populations, including those without evidence of
COVID 19 infection. Information regarding innate and adaptive immune
responses to the novel SARS-CoV-2 has evolved rapidly. Here, data are
accumulating defining disease phenotypes that aid in rational and
informed development of new therapeutic approaches for the treatment of
patients infected with SARS-CoV-2 and the development of novel vaccines.
In this article, we summarize data on important innate immune responses
including cytokines, specifically IL-6 and complement, and explore
potential treatments. We also examine adaptive immune responses and
derivative therapeutics such as monoclonal antibodies directed at spike
proteins. Finally, we explore data on real-time assessments of adaptive
immune responses which include CD4+/CD8+ T-cells, NKT-cells, memory
B-cells, and T-follicular cells with specificities for COVID-19 peptides
in infected individuals and normals. Data of two novel vaccines have
been released, both showing >95% efficacy in preventing
SARS-CoV-2 infection. Analysis of humoral and cellular responses to the
vaccines will determine the robustness and durability of protection. In
addition, long-term assessment of SARS-CoV-2 memory B and T-cell
mediated immune responses in patients recovering from an infection or
those with cross-reactive immunologic memory will help to define risk
for future SARS-CoV infections. Finally, patients recovering from
SARS-CoV-2 infection may experience prolonged immune activation likely
due to T-cell exhaustion. This will be an important new frontier for
study.
VIP-HL: Semi-automated ACMG/AMP variant interpretation platform for genetic hearing loss
Authors: Peng Jiguang , Xiang Jiale , Jin Xiangqian , Meng Junhua , Song Nana , Chen Lisha , Tayoun Ahmad Abou , Peng Zhiyu
Published: December 2020

The American College of Medical Genetics and Genomics, and the
Association for Molecular Pathology (ACMG/AMP) have proposed a set of
evidence-based guidelines to support sequence variant interpretation.
The ClinGen hearing loss expert panel (HL-EP) introduced further
specifications into the ACMG/AMP framework for genetic hearing loss.
This study developed a tool named VIP-HL, aiming to semi-automate the HL
ACMG/AMP rules. VIP-HL aggregates information from external databases to
automate 13 out of 24 ACMG/AMP rules specified by HL-EP, namely PVS1,
PS1, PM1, PM2, PM4, PM5, PP3, BA1, BS1, BS2, BP3, BP4, and BP7. We
benchmarked VIP-HL using 50 variants where 83 rules were activated by
the ClinGen HL-EP. VIP-HL concordantly activated 96% (80/83) rules,
significantly higher than that of by InterVar (47%; 39/83). Of 4948
ClinVar star 2+ variants from 142 deafness-related genes, VIP-HL
achieved an overall variant interpretation concordance in 88.0%
(4353/4948). VIP-HL is an integrated online tool for reliable automated
variant classification in hearing loss genes. It assists curators in
variant interpretation and provides a platform for users to share
classifications with each other. VIP-HL is available with a
user-friendly web interface at http://hearing.genetics.bgi.com/.
Impact of early life geohelminths on wheeze, asthma, and atopy in Ecuadorian children at 8 years.
Authors: Cooper Philip , Ster Irina Chis , Chico Martha , Vaca Maritza , Oviedo Yisela , Maldonado Augusto , Barreto Maurício , Platts-Mills Thomas , Strachan David
Published: December 2020

Background: Early-life exposures to geohelminths may protect against the
development of wheeze/asthma and atopy. Objective: Study effect of
maternal geohelminths and infections in children during the first 5
years of life on atopy, wheeze/asthma, and airways
reactivity/inflammation at 8 years. Methods: Birth cohort of 2,404
neonates followed to 8 years in rural Ecuador. Data on wheeze/asthma
were collected by questionnaire and atopy by skin prick test (SPT)
reactivity to 9 allergens. We measured airways reactivity to
bronchodilator, fractional exhaled nitric oxide (FeNO), and nasal
eosinophilia. Stool samples were examined for geohelminths by
microscopy. Results: 1,933 (80.4%) children were evaluated at 8 years.
Geohelminths were detected in 45.8% of mothers and in 45.5% of
children to 5 years. Frequencies of outcomes at 8 years were: wheeze
(6.6%), asthma between 5 and 8 years (7.9%), SPT (14.7%), airways
reactivity (10%), and elevated FeNO (10.3%) and nasal eosinophilia
(9.2%). Any maternal geohelminth was associated with reduced prevalence
of SPT (OR 0.72). Childhood T. trichiura infections were associated with
reduced wheeze (OR 0.57) but greater parasite burdens with A.
lumbricoides were associated with increased wheeze (OR 2.83) and asthma
(OR 2.60). Associations between maternal geohelminths and wheeze/asthma
were modified by atopy. Parasite-specific effects on wheeze/asthma and
airways reactivity and inflammation were observed in non-atopic
children. Conclusions: Our data provide novel evidence for persistent
effects of in utero geohelminth exposures on childhood atopy but
highlight the complex nature of the relationship between geohelminths
and the airways. Registered as an observational study (ISRCTN41239086).
Astragaloside IV Protects Against Diabetic Nephropathy by Inhibiting Pyroptosis Based on NOX4/TXNIP/NLRP3 Pathway
Authors: Zhang Yudi , Tao Chunhe , Du Donglin , Xuan Chen , Cao Wenfu
Published: December 2020

Background and Purpose: Diabetic nephropathy (DN) is a common and severe
chronic complication in diabetes mellitus. The purpose of this study was
to explore the effect and mechanism of Astragaloside IV (AS-IV) on renal
pyroptosis in DN. Experimental Approach: High-fat diet and a small dose
of streptozotocin were used to establish the DN model. Rats were treated
with vehicle or AS-IV (20-, 40- and 80-mg/kg/day) or valsartan
(30mg/kg/day) by gavage. After 12 weeks, animals were euthanized;
samples of urine and blood were collected to examine biochemical
indicators, advanced glycation end products (AGEs), inflammatory
cytokines; kidney tissues were collected for histological observation,
TUNEL staining, AGEs, inflammatory cytokines, redox indicators, western
blot, and immunohistochemistry. Key Results: Biochemical results showed
that AS-IV could significantly alleviate the degree of clinical symptoms
and the levels of blood glucose, HbA1C, TG, MDA, AGEs, Interleukin
(IL)-1β, and IL-18 while improving the activity of SOD and the secretion
and sensitivity of insulin. Histological examination and TUNEL staining
indicated that AS-IV attenuated the damage of tissues and cells in the
kidney from DN rats. Western blot results revealed that AS-IV relieved
the activation of NOX4/TXNIP/NLRP3 pathway and the expression of
collagen IV and fibronectin in DN rats. Immunohistochemistry results
showed that AS-IV attenuated collagen IV and fibronectin in the kidney
from DN rats. Conclusion and Implications: The NOX4/TXNIP/NLRP3 pathway
mediated renal pyroptosis could play a crucial role in kidney damage and
DN development in rats. Restoration of renal pyroptosis by AS-IV be a
potential therapeutic strategy against DN.
Advancement of Epigenetics in Stroke Research
Authors: Ghosh Dipritu , Peng Jianhua , Yin Shigang , Jiang Yong
Published: December 2020

With the advancement of epigenetic tools and technologies associated
with intervention medicine, stroke research has entered into a new
fertile, dynamic era of epigenetic studies, a wide plethora of
intervention procedure, administration of tissue plasminogen activator,
the introduction of mechanical thrombectomy, clinical studies, and drug
developments over the last decennium. Against this vivid background of
newly emerging pieces of knowledge, there is little to none advancement
in the overall outcome of the disease. The stroke involves an
overabundance of inflammatory responses arising in part due to the
body’s immune response to brain injury. Neuroinflammation contributes to
significant neuronal cell death and the development of functional
impairment and death in stroke patients. Recent studies demonstrated
epigenetic plays a key role in the overall outcome of the disease. In
this review, we summarize the progress of epigenetics which provides an
overview of recent advancements on the emerging key role of epigenetics
over the last decade contributing to the regulation of neuroinflammation
in stroke, potential epigenetic targets that might be key factors in the
development of stroke therapies and their relation in respect to
clinical practice.
Does the RECOVERY dexamethasone improve COVID-19 mortality?
Authors: Kelleni Mina
Published: December 2020

On the same day the results of the RECOVERY study was published; July
17, 2020, we have submitted a letter to New England Journal of Medicine
(NEJM, ID 20-25534) representing some concerns about this study and its
status was with editor until November 29, 2020 on which a withdrawal
request has been sent to NEJM and was promptly accepted on the following
day. Notably, four emails were sent to NEJM, once every month wondering
about this unprecedent delay in publishing a short letter and the
response was that the editor has been contacted on multiple occasions
but he/she is busy because of the large number of COVID-19 related
submissions.
Oplus-g-Radical Supplemented Modules
Authors: Nebiyev Celil , Özdemir Hilal
Published: December 2020

In this work oplus-g-radical supplemented modules are defined and some
properties of these modules are investigated. It is proved that the
finite direct sum of oplus-g-radical supplemented modules is also
oplus-g-radical supplemented.
Do Abnormal IPO Audit Fees Signal IPO Audit Quality and Post-IPO Performance? A Principal-Agent Analysis Based on Evidence from China
Authors: Chan K. Hung , Mo Phyllis Lai Lan , Zhang Weiyin
Published: December 2020

We assess the unexplained information content of abnormal audit fees using a sample of initial public offering (IPO) audits in China. We find that abnormal IPO audit fees are positively associated with manipulation of pre-IPO real activities, suggesting lower audit quality for IPO financial statements. We further find that abnormal IPO audit fees are negatively associated with post-IPO financial performance. These results suggest a strong alignment of interests between the principal (pre-IPO shareholders), whose main interest is to gain listing status, and its agent (the auditor), who is willing to cooperate with the principal for extra economic rents (abnormal audit fees). Our findings that abnormal IPO audit fees are associated with lower audit quality and can help predict post-IPO financial performance have important implications for audit regulators, IPO market participants, and the applicability of agency theory in the context of IPO audits.

JEL Classifications: M43; M49.
Phenological phenomena in the life of plants in Zhiguli Nature Reserve in the changing climate (using the example of Laser trilobum and Euphorbia zhiguliensis)
Authors: Kiseleva Darya S.
Published: December 2020

Phenological processes of two rare species, Laser trilobum and Euphorbia zhiguliensis, in Zhiguli Reserve, and their changes associated with climate change during more than 38 years of observations are discussed. Long-term weather condition phenorhythms in the reserve were summarized, and the behavior of the plants in the changing environment was studied..
A renewed search for meaning?
Authors: Stensaker Bjørn
Published: December 2020

Book review: The responsible university – exploring the Nordic context and beyond (2019). Sørensen,Mads, Geschwind, Lars, Kekäle, Juoni & Pinheiro, Rómulo (Eds.) PalgraveMacmillan(Open access). https://10.1007/978-3-030-25646-3
Balansert målstyring som økonomistyringsverktøy i norske foretak: Utviklingstendenser i perioden 2015–2018
Authors: Johanson Daniel , Madsen Dag Øivind , Stenheim Tonny
Published: December 2020

Tidligere forskning har vist at norske foretak benytter ulike typer styringsverktøy. I dette kapitlet fokuserer vi på et spesifikt styringsverktøy, balansert målstyring (BMS). og ser nærmere på utviklingstendenser knyttet til spredningen, bruken og effektene av BMS i praksis i perioden 2015–2018. Studien bruker data fra to elektroniske spørreundersøkelser av bruken av BMS i norske foretak gjennomført i 2015 og 2018. Undersøkelsen fra 2015 omfattet bare store foretak, mens den fra 2018 omfattet både store og mellomstore foretak. Resultatene viser at BMS er et utbredt styringsverktøy blant store og mellomstore norske foretak. Selv om flertallet bruker BMS som et relativt enkelt prestasjonsmålingssystem, er det en tendens at bruken blir mer avansert. Disse funnene blir diskutert i lys av den internasjonale forskningslitteraturen om BMS spesielt og økonomistyringsverktøy generelt.
Investigation on modeling and simulation BLDC motor fed universal actuation system
Authors: Murali M. , Arulmozhiyal R.
Published: December 2020

This paper deals with mathematical modeling of Permanent magnet brushless DC (BLDC) motor in MATLAB-SIMULINK environment. Modeling of BLDC motor carried in transfer function, transfer equations and state space model to verify the performance as actuators. Mathematical switches to control electronic commutation of BLDC motor based on signals of Hall Effect position sensor using three-phase inverter drive. Performance of the simplified mathematical inverter fed BLDC motor under steady state and dynamic conditions analyzed. Due to the switching losses during PWM generation generates low ripple content in torque of BLDC motor which described and eliminated through state space model. Comparison made of proposed modeling of BLDC motor with motor parameters like back-EMF, stator current and speed of BLDC motor, proposed work suggests the state space modeling holds a superior method for design of BLDC motor during high dynamic load performance and operating ranges.
Civilizational Approach in Political Prognostics and the Borders of the Secular World
Authors: Rastorguev Valery N. 
Published: December 2020

The article considers the illusory nature of secularism and the concept of “secular priesthood” as a minority, replacing sacred authority through the use of constitution to implement political ideologies. The circle of problems included into the framework of the “post-secular” is determined. A civilizational approach is proposed to solve the problem of preserving the state identity in post-secular world
The Political Identity of the Japanese: A Hybrid of Religious and Secular
Authors: Chugrov Sergey V.
Published: December 2020

The article analyzes the specifics of Japanese religious syncretism, which managed to adapt with great efficiency the norms of the Buddhist-Confucian complex and the autochthonous religion of Shinto. Japan is a vivid example of the harmonization of national identity, based not only on the high level of homogeneity of society, but also on the high degree of tolerance and ability to adapt and to adopt. In the political sphere, the Japanese post-secular system demonstrates the capacities of the Komeito party (Party of Pure Politics), which was created on the basis of Soka Gakkai Buddhist organization, which professes the humanistic ideas of Nichiren (1222–1282), set forth in the Lotus Sutra. Now the Komeito party plays an important role in shaping Japanese politics, coalescing with the dominant Liberal Democratic Party. The Komeito party, in particular, is effectively advocating the preservation of the 9th ‘pacific’ article of the constitution. The movement of laic Buddhists Soka Gakkai International (SGI), operating in 93 countries around the world, is widely known for cultural and educational activities and its struggle to ban nuclear weapons. Thus, Japan provides a pointed example of the combination of humanistic philosophy of human dignity and empowerment with political activity, which determines the nature of Japanese post-secular society.
“Approaching the Issues of Faith with Maximum Care…”: the Policy of North-West Region “Parish” Russification and the Vilna Governor-General Prince P.D. Sviatopolk-Mirsky*
Authors: Krot Maxim N.
Published: December 2020

The nationalist issue was one of the most difficult problems faced by the Russian Empire at the turn of the 19th and 20th centuries. The policy of depolonization, actively pursued by the imperial authorities in the northwestern outskirts of the country, mainly by administrative and police methods, did not bring tangible positive results, causing discontent and resistance of the local population, which threatened to destabilize the situation in the region. Restrictions in the religious sphere and attempts to forcibly propagate Orthodoxy in the region by expanding the network of parish schools, which were actively opposed by the local Catholic Church, were especially painful for the local Polish, Lithuanian and Belarusian population. The article examines the transformation of the imperial policy in the educational and enlightening spheres in the Northwestern Territory during the tenure of Prince P.D. Sviatopolk-Mirsky, who adhered to the new model of managing the national outskirts, taking into account the needs and interests of the local population. The Governor-General considered it necessary to abandon the forcible propagation of Orthodoxy among the local population and the use of the parish school as the instrument of Russification policy, advocating the spread of state secular education, freedom of religion and the use of national languages ​​and writing in teaching the local population.
Uniate Issue in the Russian Government Police in Galicia in the Period of the First World War
Authors: Polunov Alexander Yu.
Published: December 2020

The article examines the aspects of the confessional policy in the territory of Galicia in the period of its occupation by the Russian army in the end of 1914 and the beginning of 1915. The author pays attention to the factors of confessional policy development related to the activities of the Russophile (“Moscow-phile”) party in Galicia and the initiatives of Russian social and church circles sympathizing with pro-Russian Galicians. The author believes that Galicia’s place in the public conscience was largely determined by the symbolic significance of that region, - the last part of the East-Slavic area that was not a part of Russia by the beginning of the 20th century. Relying on the attitude of the Galician “Russophiles”, the nationally-oriented Russian church and public circles counted on the quick spreading of the Orthodoxy and Russian culture in the annexed areas. Most of those expectations did not come true, both due to the terroristic campaign against “Russophiles” conducted by the Austrian administration just after the break o the war, and due to the interdepartmental contradictions complicated by the activity of the Russian authorities.
Russian Conservative Romanticism Concept of Andrzej Walicki
Authors: Maslin Mikhail A. , Volkonskaya Alena A.
Published: December 2020

The present article gives a review of the book “In the Circle of Conservative Utopia. Structure and Metamorphoses of Russian Slavophilism” by the world-known historian of Russian thought and member of the Polish Academy of Sciences Andrzej Walicki, that was published in Russian translation one year before the death of its author. The book is based on the original author’s conception of Russian conservatism reflecting the national peculiarities of Russian philosophy in the 18th and 19th centuries. According to Walicki, the essence of conservatism consists not in the legitimism and protection of the existing social and state order, but in the certain worldview and thinking style that oppose liberalism and rationalistic philosophy of the Enlightenment represented as various concepts of conservative philosophic romanticism. Those concepts were reflected in the ideas of the Slavophils A. Grigoriev, V. Odoevsky, K. Leontiev, A. Herzen, V. Soloviev and others.
Creative Writing Special Edition Introduction
Authors: Wilson Jani
Published: December 2020

Iti te kupu, nui te kōrero (Few words have huge meaning): Writing (in) Māori Shorts.

Introduction to this special edition.
Sobre Roberto Domínguez Cáceres y Víctor Gayol (coords.), El imperio de lo visual. Imágenes, palabras y representación
Authors: Garone Gravier Marina
Published: December 2020

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A Multi-Phase 20th-Century Military Landscape Near Shipton Bellinger, Salisbury Plain
Authors: Beach Stephen , Clarke Bob , Mepham Lorraine A
Published: December 2020

The investigation of a World War I (WWI) practice trench system on Salisbury Plain has revealed a wealth of detail about the construction and use of this military landscape. The archaeological works has also led to the recognition of at least three later periods of activity on the site,
all connected with aspects of conflict, including World War II (WWII) and the Korean War. Finds comprising a mixture of issued equipment and personal objects from the excavations provide evidence of the conditions experienced by personnel while in training on Salisbury Plain. A particularly
interesting find is a copper alloy cane finial marked O. T. C. (Officer Training Corps) and embellished with the coat of arms of William of Wykeham, the founder of Winchester College. The examination of aerial photographs further complements the excavation results available, allowing for the
construction of a complex narrative for this corner of Hampshire.
Espacios de resistencia
Authors: Pires Catarina
Published: December 2020

Las prácticas artísticas activistas son un medio importante de contestación e imponen desafíos al discurso hegemónico. En este artículo analizamos la subversión como estrategia de resistencia, que opera transformando el espacio institucional en una arena cultural, donde se cuestiona la hegemonía y se confrontan diferentes perspectivas. Como estudio de caso, presentamos la obra Subsidy del artista Joshua Schwebel, cuyo enfoque es la realidad laboral del sector artístico en el capitalismo contemporáneo.
Debatir la historia
Authors: Lucero María Elena
Published: December 2020

Este artículo plantea un debate sobre los modos tradicionales que la Historia del Arte ha implementado para el ordenamiento y la lectura de las imágenes. Se analizarán dos curadurías que problematizaron la relación entre historia y producción visual. La primera corresponde a la exhibición «El tiempo del arte. Obras siglos XVI al XXI» en Fundación PROA (2009), organizada con base en tópicos que impregnaron los movimientos artísticos. En segundo lugar, se analizará Verboamérica (2016), inaugurada en el Museo de Arte Latinoamericano de Buenos Aires. En este caso se instauraron ocho ejes a partir de los cuáles se agruparon artistas de la colección del museo. La investigación describe de qué manera estos itinerarios visuales socavaron los límites cronológicos de la tradición occidental.
La politización de la música en la experiencia estética
Authors: Marchiano María , Martínez Isabel Cecilia
Published: December 2020

Walter Benjamin acuñó el concepto de politización del arte a partir de dos fenómenos emergentes de la reproducción técnica de la imagen: la subversión de la ontología de la obra de arte tradicional y el uso del cine como propaganda política del fascismo. En este artículo analizamos las ontologías de la música en diálogo con los planteos de Benjamin sobre las artes visuales, para luego desarrollar el concepto de politización de la música. Concluimos que la politización de la música es un fenómeno que se articula en la experiencia que las personas tienen con la obra y no solo en la obra misma, planteo que se sustenta solo desde una ontología de la música como experiencia.
Desenvolvimento e utilização de recursos educacionais abertos no grupo PET Saúde/ Interprofissionalidade - Redes de atenção da UFPR
Authors: Gritten Marcel Pereira , Signorini Liana , Souza Maria Gabriela Rodrigues de , Heiden Nicolle Boell , Rosa Leandra , Lima Allan Kardec de , Lourenço Rafaela Gessner
Published: December 2020

Introdução: Os Recursos Educacionais Abertos (REA) são definidos como materiais de ensino, pesquisa e extensão, publicados sob licença aberta ou em domínio público. Por isso, são caracterizados como um bem comum, com pouca ou nenhuma limitação de direito autoral. Visam promover a equidade na educação, tornando-a inclusiva e de qualidade, mediante colaboração e compartilhamento de conhecimento de forma gratuita1. Objetivo: relatar a experiência da criação de dois materiais educativos publicados como Recursos Educacionais Abertos no Repositório Digital da Universidade Federal do Paraná. Metodologia: trata-se de um relato de experiência de natureza descritiva. Resultados: Os REAs foram desenvolvidos nos meses de abril e junho de 2020 e orientados pelos princípios de colaboração e interatividade dos meios digitais. O primeiro REA, elaborado em formato de cartilha e intitulado “Manual de Tubos de Coleta de Sangue”, foi criado como proposta de intervenção em um dos equipamentos de saúde do município de Curitiba em que se desenvolvem atividades de preceptoria do grupo PET Saúde/Interprofissionalidade – Rede de Atenção. Esse REA contempla os principais tubos de coleta de sangue utilizados na rotina ambulatorial, abordando a finalidade e importância de cada um, para garantir a viabilidade das amostras e a qualidade dos resultados laboratoriais. Esse material atingiu, até agosto de 2020, 161 visualizações, sendo 70% (112) delas de alcance internacional2. O segundo REA, em formato de cartilha, “Diagnóstico Laboratorial do Coronavírus (Sars-Cov-2) (agente etiológico da COVID-19)”, mostra os princípios, vantagens e as principais diferenças entre os dois principais métodos laboratoriais utilizados para o diagnóstico da COVID-19: o teste molecular (RT-PCR em tempo real) e o teste sorológico (teste rápido). Com impacto semelhante, tal publicação obteve 179 visualizações, sendo a maioria delas 84% (150) realizadas em outros países3. Esse material objetiva oferecer suporte a acadêmicos, profissionais de saúde e à comunidade externa sobre temática relevante da atualidade. Considerações Finais: A utilização da modalidade de Educação Aberta apresenta vantagens como, o custo reduzido, promoção da ampliação do acesso à educação e o alcance global das publicações, conforme foi observado nos REA produzidos e disponibilizados pela equipe do PET Redes de Atenção da UFPR. Dessa forma, além de priorizar a difusão do conhecimento produzido em suas atividades, a equipe buscou novas maneiras de contribuir para o debate e intercâmbio entre diferentes teias da produção científica.

Palavras-chave: Educação Continuada. Educação Interprofissional. Materiais de Ensino.
KONTEKS PENGUBURAN KOMPLEKS MAKAM KUNO SUTAN NASINOK HARAHAP
Authors: Nasoichah Churmatin , Restiyadi Andri , Oetomo Repelita Wahyu , Susilowati Nenggih , Soedewo Ery , Khairunnisa Nfn , Karina Purba Ivonne Visse
Published: December 2020

The form of burial in the ancient tomb complex of Sutan Nasinok Harahap is in the form of a mound of land bordered by flat stones. The problem is what the burial context and the characteristics of the tomb in the Sutan Nasinok Harahap Ancient Tomb Complex?. The purpose of this study is to determine the context of burial and recognize the complex characteristics of the tomb. This study uses an inductive reasoning model. Judging from the characteristics, the characteristics of the tomb have not yet been seen, only the orientation of the tomb indicates the absence of Islamic influence. Related to the burial context, the tomb is located far from the river, on a high place (dolok) and is in the banua partoru zone while Lobu Gunung Tua Batang Onang is in banua tonga which is adjacent to the banua parginjang zone (close to the river). Bentuk penguburan di Kompleks Makam Kuno Sutan Nasinok Harahap berupa gundukan tanah yang pada bagian tepiannya dibatasi oleh batu-batu pipih. Permasalahannya adalah bagaimanakah konteks penguburan serta karakteristik makam di Kompleks Makam Kuno Sutan Nasinok Harahap?. Tujuan dari penelitian ini adalah untuk mengetahui konteks penguburan dan mengenali karakteristik kompleks makam tersebut. Penelitian ini menggunakan model penalaran induktif. Dilihat dari karakteristiknya, belum terlihat karakteristik makamnya, hanya orientasi makam yang menunjukkan belum adanya pengaruh Islam. Terkait konteks penguburannya, makam berada di lokasi yang jauh dari sungai, tinggi (dolok) dan berada dalam zona banua partoru sedangkan Lobu Gunung Tua Batang Onang berada di banua tonga yang berdekatan dengan zona banua parginjang (dekat dengan sungai).
PERBANDINGAN KINERJA RUAS JALAN AKIBAT ZONA SELAMAT SEKOLAH (ZoSS) DI KOTA DENPASAR
Authors: Kariyana I Made , Aryastana Putu
Published: December 2020

Kota Denpasar merupakan pusat kegiatan ekonomi, pendidikan, kesehatan dan pemerintah di Provinsi Bali. Kota Denpasar memiliki jumlah penduduk tertinggi dibandingkan dengan kabupaten lainya. Peningkatan jumlah penduduk menyebabkan kebutuhan sarana pendidikan juga semakin meningkat. Pemenuhan sarana pendidikan tentunya akan membebani jaringan jalan, seperti fasilitas Zona Selamat Sekolah (ZoSS) yang fungsinya untuk menjaga keamanan anak masuk dan pulang sekolah. Penelitian ini bertujuan untuk menganalisis kinerja ruas jalan sebelum ZoSS dan di kawasan ZoSS. Survey volume lalu lintas pada 3 sekolah dasar di Denpasar dilakukan pada jam puncak pagi dan siang hari. Analisis kinerja ruas jalan menggunakan panduan Manual Kapasitas Jalan Indonesia (MKJI) 1997. Hasil penelitian menunjukan bahwa, derajat kejenuhan sebelum ZoSS SDN 5 Pedungan 0,83 sedangkan dikawasan ZoSS 0,85, derajat kejenuhan sebelum ZoSS Sekolah Harapan 0,72 sedangkan dikawasan ZoSS 0,81 dan derajat kejenuhan sebelum ZoSS SDN 3 Peguyangan 0,68 sedangkan dikawasan ZoSS 0,71.
Vertical shift of submerged body moving near the free surface
Authors: Zemlyak Vitalyov L. , Kozin Viktor M. , Vasiliev Aleksey S.
Published: December 2020

Object and purpose of research. The object of the research is model tests of the submerged body motions near the free surface in test basin. The purpose of the study is to determine how the magnitude of the relative vertical shift of the submerged body depends on its speed. Materials and methods. The material for research is the modeling technique, technology and the results of model experiments in the test basin. Numerical modeling was performed using the ANSYS software package. Main results. Model tests and numerical experiments were carried out to determine the magnitude of the vertical displacement of the submerged body moving near the free surface and the forces acting on it. Conclusion. The results obtained are useful for horizontal stabilization of submerged body moving near free surface at different speeds.
Petrography and Physicomechanical Characteristics of Iyuku Granite, Southwestern Nigeria
Authors: Ugbe Felix Chukwuka
Published: December 2020

Petrography and physicomechanical characteristics of Iyuku granite from southwestern Nigeria were investigated. Rock and aggregate samples were obtained from five different quarry sites for thin-sectioning and physical and mechanical tests. The rock slides were subjected to petrographic analysis, while the aggregates were tested for the parameters of specific gravity (S.G), water absorption, aggregate impact value (AIV), aggregate crushing value (ACV), Los Angeles abrasion value (LAAV), and flakiness and elongation indices in accordance with the British Standards (B.S), American Standards for Testing Materials (ASTM) and Federal Ministry of Works Standards (FMWS). The petrographic, physical, and mechanical characteristics were described by bar charts and linear graphs. The results revealed that the rocks are of medium to coarse interlocking grains, with no evidence of weathering influences, and quartz content ranging from 17% to 35%. The aggregates showed appreciable high S.G. values, very low water absorption values and low maximum permission limits for AIV, ACV and LAAV when compared with different standards. All the aggregates are adjudged to be generally strong and durable for road construction, but those with higher quartz contents are more preferable. Significant statistical correlations were established among both physical and mechanical tests conducted.
Guru profesional di era new normal: Review peluang dan tantangan dalam pembelajaran daring
Authors: Jamilah Jamilah
Published: December 2020

Saat ini pemerintah memberlakukan kebijakan pembelajaran daring  untuk memperlambat penyebaran virus corona di Indonesia. Guru merupakan pihak yang harus mengikuti pola kebijakan yang dikeluarkan oleh pemerintah tersebut.  Artikel ini bertujuan untuk mereview bagaiamana guru professional di era new normal antara peluang dan tantangannya dalam pembelajaran daring. Penelitian ini merupakan studi literatur  atau pustaka tentang informasi guru professional di era new normal.  Data primer diambil dari tulisan atau artikel tentang guru di era new normal. Analisis datanya menggunakan content analysis. Hasil review ini menujukkan bahwa guru mengikuti kebijakan pemerintah dalam pembelajaran daring. Peluang dari pembelajaran tersebut guru dituntut untuk lebih menguasai teknologi dan bisa menyesuaikan dengan keadaan apapun. Tantangannya adalah kemampuan guru tersebut dalam menguasai teknologi, sumber daya manusia, sarana prasarana yang dapat mendukung proses pembelajaran daring. Untuk itu rekomendasi yang harus dilakukan adalah membangun kemitraan anatara orang tua, guru dan stakeholder secara berkelanjutan. Serta perlu adanya evaluasi terhadap proses pembelajaran daring agar tujuan dan hasilnya bisa tercapai secara optimal.
STRATEGI PENINGKATAN PERTUMBUHAN DANA ZAKAT PADA BADAN AMIL ZAKAT NASIONAL KABUPATEN BENGKALIS
Authors: Sulistyandari
Published: December 2020

Penelitian ini bertujuan untuk mengetahui strategi dalam meningkatkan pertumbuhan dana zakat di Kabupaten Bengkalis. Penelitian  dilakukan dengan pendekatan kualitatif dengan metode deskriptif yang datanya diperoleh melalui  wawancara, observasi, dokumentasi dan literature review. Hasil penelitian menunjukkan bahwa strategi yang dipakai oleh Badan Amil Zakat Nasional Kabupaten Bengkalis untuk meningkatkan pengumpulan dana zakat adalah  dengan peningkatan kerjasama dengan berbagai instansi termasuk instansi pemerintah; menambah frekuensi sosialisasi melalui pelaksanaan seminar dan workshop zakat; meningkatkan kompetensi SDM amil, UPZ dan relawan serta mengembangkan sistem ICT dalam pengelolaan zakat. Sedangkan yang menjadi hambatan adalah kurangnya pemahaman masyarakat tentang zakat dan kurangnya kepercayaan masyarakat kepada Badan Amil Zakat Nasional Kabupaten Bengkalis. Adapun solusi yang diterapkan oleh BAZNAS Kabupaten Bengkalis untuk mengatasi hambatan diantaranya adalah transparansi pengelolaan; modernisasi pengelolaan dan publikasi.
A STUDY OF THE ALKYLPROPARGYL RADICAL ELECTRON STRUCTURES IN THE FRAMEWORK OF QTAIM
Authors: Чернова Елена Михайловна , Репин Андрей Анатольевич , Туровцев Владимир Владимирович , Орлов Юрий Димитриевич
Published: December 2020

Методом DFT B3LYP/6-311++G(3df,3pd) найдено распределение электронной плотности соединений гомологического ряда пропаргильных радикалов. В рамках квантовой теории атомов в молекуле (QTAIM) проведено исследование их электронного строения, выделен радикальный центр и отмечена делокализация спиновой плотности по значительному объему радикалов, что можно объяснить в рамках классической теории как суперпозицию структур.

The electron density of the homologues of the propargyl radical series were found by DFT B3LYP/6-311++G(3df, 3pd) method. Within the “quantum theory of atoms in a molecules” (QTAIM) their electron structures were studied, radical centres were specified and it was shown that the spin density was delocalized over a significant volume of radicals. This phenomenon can be explained in the framework of classical theory as a superposition of structures.
浅谈水利水电工程施工中的防水截渗技术
Authors: 孙 昱
Published: December 2020

随着中国社会不断发展，经济实力不断提高，人民的生活水平越来越好，水利水电工程也在蓬勃发展中。水利水电工程是一项非常复杂、技术性很高的工作，这关系到国家和人民的安全，所以水利水电工程的安全问题非常重要。论文对水利水电工程施工中的防水截渗技术进行研究和分析。
老挝南俄5水库大坝加高方案可行性初步探讨
Authors: 陈 志超
Published: December 2020

南俄5水电站大坝加高不能解决水库流域来水不足的问题，改变水库特性，通过电站调频调峰，可以增加发电收益。但是只改变水库特性而增高大坝，建设成本较高。论文基于南俄5水电站水文资料，探讨不增加工程投入的前提下提高电站的调频调峰能力的方法，通过科学调度解决水库来水不足的问题。
房产测绘技术与测绘质量的控制探究
Authors: 孙 彬
Published: December 2020

目前，社会在不断进步，路网也一直在优化和增加，建筑行业也在快速发展。在这样的大环境下，工程测绘行业对工程质量要求也一直在提升。中国在测绘工程质量的合格率方面与别的国家相比有着很显著的优势，并且中国测绘企业有自己的科学运作方法和非常完善的理论模型和技术体系。测量工作是建筑工程项目中的基础工作，其质量与建筑工程质量、使用寿命存在密切关联。论文主要针对测绘新技术的应用进行分析，阐述测绘技术在建筑工程测量中的质量控制，以期为建筑工程测量质量及工程测绘质量的提高提供理论支持。
浅析工程测绘中的GPS测绘技术
Authors: 周 华朔
Published: December 2020

随着城镇化进程的不断加快，各种建设项目不断增加，只有保证工程建设安全，才能推动城市发展。工程测绘精准程度决定了工程的安全性与稳定性，传统测绘技术主要依靠人工来完成，往往会出现一些误差。现代技术的创新发展，推动了 GPS 技术民用历程。可以说，GPS 技术在很多领域都已经在发挥了作用，全面的深入到人们生活生产各个层面，工程测绘也离不开GPS 的应用。论文通过 GPS 技术重要性阐述，全面分析了工程测绘中 GPS 应用。
农业面源污染的现状及防治对策
Authors: 曹 宁
Published: December 2020

面源污染，主要是指固体的污染物，或者可溶于水的污染物，在一定程度的地面降水或者在地表径流的影响下，扩散并进入水体，最终致使地表水遭受污染。农业面源污染，则是指因农业生产活动所存在的特性，使农药、化肥以及禽畜粪便等在农业生产过程中所产生的污染物为主要污染物，并在农业区域由一定方式最终对农业生产所需的水体产生污染。此外，农村生活中所产生的日常生活垃圾的随意丢弃以及农业污物的滥堆滥放也会造成农业面源污染。农业面源污染不仅会导致农业生产水体中的富营养化程度增高，使有害微量元素增加，不利于农户健康和农业生产进一步发展，同时还会破坏整个农村生态系统的平衡，威胁整个生态圈的和谐。农业面源污染的治理是乡村生态振兴的重要举措，农户是农业生产中最基本的决策单位，也是导致农业面源污染的重要微观主体，通过剖析农户生产行为选择及其与农业面源污染之间的关系，充分认识农户生产行为对农业面源污染影响的成因，以便提出合理的政策措施，为农业面源污染的防治提供切实可行的政策建议。
МЕСТО И ЗНАЧЕНИЕ ДИЛЕРСКИХ КОМПАНИЙ В АВТОМОБИЛЬНОМ РЫНКЕ РОССИИ
Authors: Рожкова Надежда Константиновна
Published: December 2020

Цель работы. В статье проанализирована роль сети дилерских организаций, сложившаяся на российском автомобильном рынке. Метод проведения работы. Системный подход к статистическому анализу структуры рынка автомобилей. Результаты. Дилерская компания представляет собой коммерческую организацию, которая занимает промежуточное место при продаже автомобилей, образуя последовательную цепь: производитель автомобиля – дилерская компания – конечный покупатель. Кроме того, дилерская компания оказывает прочие услуги, основой которых являются работы по поведению автомобиля до товарного вида. В результате анализа рынка автомобилей в России за ряд лет было доказано, что эффективность работы дилерских компаний находится в тесной зависимости от определенных факторов, таких как объем производства, марка автомобиля, производитель и т. п. На основании статистических данных автомобильного рынка России приведены доказательства того, что на деятельность как дилерской организации, так и дилерских центров оказывает достаточно значительное влияние конкуренция. Область применения результатов. Результаты данного исследования целесообразно применять для изучения рынка автомобилей как в России, так и за рубежом. Выводы. Проведенный анализ автомобильного рынка России показал его глобальность и зависимость как от макроэкономических показателей, так и от элементарного спроса на выпускаемую продукцию.
ТЕХНИКО-ТЕХНОЛОГИЧЕСКАЯ СОСТАВЛЯЮЩАЯ КОНКУРЕНТОСПОСОБНОСТИ АПК ПРОМЫШЛЕННОГО РЕГИОНА (НА МАТЕРИАЛАХ КЕМЕРОВСКОЙ ОБЛАСТИ)
Authors: Лубкова Эльмира Миннулловна
Published: December 2020

Цель работы. В статье проведено исследование технико-технологической составляющей конкурентоспособности АПК промышленного региона. Методы или методология работы. На основе статистических данных выявлены изменения в обеспеченности сельхозпроизводителей промышленного региона (на примере Кемеровской области) техникой в разрезе муниципальных образований. Дана оценка инфраструктуры крестьянских (фермерских) хозяйств и индивидуальных предпринимателей объектами инфраструктуры. Результаты. Установлены тенденции, которые позволяют определить основные направления и динамику развития технико-технологической составляющей конкурентоспособности АПК промышленного региона. Обеспеченность муниципальных образований техникой за исследуемый период имеет различные тенденции. С одной стороны, это обусловлено спецификой деятельности организаций в отдельно взятом муниципальном образовании (специализация на добывающей и/или обрабатывающей промышленности), с другой стороны, связано с уровнем инвестиций в АПК. Такая направленность и динамика позволяют сделать вывод, что для повышения конкурентоспособности АПК промышленного региона основным направлением становится развитие АПК на основе создания высокотехнологичных производств. Область применения результатов. Результаты проведенного исследования могут быть использованы при разработке или корректировке Стратегий развития АПК промышленных регионов, а также при формировании карт локализации и размещении высокотехнологичных производств, которые позволят производить продукцию глубокой переработки. Выводы. Конкурентоспособность АПК промышленных регионов напрямую зависит от его технико-технологического состояния. Дальнейшее развитие АПК и повышение его конкурентоспособности во многом обусловлено дополнительными инвестициями в глубокую переработку и производства инновационного типа.
КОНЦЕПТУАЛЬНЫЕ ОСНОВЫ УПРАВЛЕНИЯ НАЛОГОМ НА ИМУЩЕСТВО ОРГАНИЗАЦИЙ
Authors: Бушинская Татьяна Владимировна , Булдыгин Павел Александрович , Артемова Анастасия Игоревна
Published: December 2020

В статье показано, что российская модель налогово-бюджетного федерализма ограничивает реализацию фискальной и регулирующей функций налога на имущество организаций, что негативно сказывается на уровне доходов региональных бюджетов. Цель работы. Обосновать необходимость разработки концептуальных основы управления налогом на имущество организаций с учетом рыночной специализации хозяйства региона, выявить инструменты управления налогом на имущество организаций, адекватные для каждого типа региона, не выходящие за пределы компетенции органов власти субъектов РФ и не влекущие рост налоговой нагрузки. Метод и методология проведения работы. На основе системного и территориально-отраслевого подхода, методов анализа и синтеза делаются выводы о необходимости формирования комплексного механизма управления налогом на имущество организаций, обеспечивающего снижение зависимости региональных бюджетов от межбюджетных трансфертов. Механизм управления налогом на имущество организаций авторы рассматривают как элемент более сложной системы управления налогообложением в регионе. Эмпирической основой представленного исследования являются труды отечественных ученых по вопросам формирования налоговой политики. Информационной основой работы являются официальные данные Росстата, Федерального казначейства, Федеральной налоговой службы Российской Федерации. Результаты. Авторами проанализирован вклад налога на имущество организаций в формирование доходов бюджетов старопромышленных регионов Центрального федерального округа, проведена оценка качества налогового планирования на основе анализа отклонений фактических поступлений налога от плановых, оценка эффективности контрольно-надзорной деятельности, исходя из уровня и динамики задолженности по налогу, исследованы отраслевая структура поступлений налога на имущество организаций в бюджет, итоги перехода к расчету налога на имущество организаций, исходя из кадастровой стоимости имущества, особенности и результаты применения льгот. Выводы. В результате проведенного исследования выявлены и обоснованы группы мероприятий в системе управления налогом на имущество организаций, которые соответствуют инструментам налогового механизма, адекватны рыночной специализации региона и могут обеспечить рост доходов бюджета без увеличения налоговой нагрузки.
THE FORMATION OF READINESS OF FUTURE MANAGERS OF GENERAL EDUCATION INSTITUTIONS TO USE INNOVATIVE PEDAGOGICAL TECHNOLOGIES IN PROFESSIONAL ACTIVITIES: THE RESULTS OF THE EXPERIMENT
Authors: Miskevych Liudmyla
Published: December 2020

The article is devoted to the results of the pedagogical experiment, checking the effectiveness of the Optional course "Formation of preparedness of future managers of general educational establishments to use innovative pedagogical technologies in professional activities". Quantitative and qualitative indicators of the data obtained during the study showed a positive impact of the proposed optional course on the formation of preparedness of future managers of general educational establishments to use innovative pedagogical technologies in professional activities. The article highlights the results of a study conducted among students of the second level of higher education, specialty 073 "Management", educational program "Management of the educational institution". The study used a questionnaire to determine the level of knowledge about innovative pedagogical technologies of future managers of general educational establishments (author’s development), a questionnaire to study the abilities of the individual to creative self-development (I. V. Nikishyn) and a questionnaire to determine the motivation of vocational training V. G. Katasheva. The generalized dynamics of levels of preparedness of future managers of general educational establishments to use innovative pedagogical technologies in professional activities before and after formative experiment in the form of diagrams is presented. In order to assess the statistical significance of the dynamics of changes in the levels of preparedness of future managers of general educational establishments to use innovative pedagogical technologies in professional activities and to assess the differences between the indicators of control and experimental groups as a results of experimental work, the methods of mathematical statistics was used – Pearson criterion χ2 ("chi-square test").