bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical, immunological features and follow up of 20 patients with dedicator of cytokinesis 8 (DOCK8) deficiency
Authors: Haskologlu Sule , Kostel Bal Sevgi , Islamoglu Candan , Aytekin Caner , Guner Sukru , Sevinc Selin , Keles Sevgi , Kendirli Tanil , Ceylaner Serdar , Dogu Figen , Ikinciogullari Aydan
Published: February 2020

Biallelic mutations in the dedicator of cytokinesis 8 gene (DOCK8) cause a progressive combined immunodeficiency (CID) characterized by susceptibility to severe viral skin infections, atopic diseases, recurrent respiratory infections, and malignancy. Hematopoietic stem cell transplantation (HSCT) is only curative treatment for the disease. However, there is limited information about long‐term outcome of HSCT and its effect to protect against cancer development in DOCK8‐deficient patients. In this study, we retrospectively evaluated clinical and immunologic characteristics of 20 DOCK8‐deficient patients and outcome of 11 patients who underwent HSCT. We aimed to report the experience of our center and the result of the largest transplantation series of DOCK8 deficiency in our country. Median follow‐up time is 71 months (min‐max: 16‐172) in all patients and 48 months (min‐max: 5‐84) in transplanted patients. Atopic dermatitis (18/20), recurrent respiratory tract infections (17/20), and food allergy (14/20) were the most frequent clinical manifestations. Failure to thrive (13/20), liver problems (12/20), bronchiectasis (11/20), chronic diarrhea (10/21), and autism spectrum disorders (3/20) were remarkable findings in our series. Elevated IgE level (20/20) and eosinophilia (17/20), low IgM level (15/20), and decreased CD3+ T (10/20) and CD4+ T (11/20) cell count were prominent laboratory findings. HSCT was performed in 11 patients. All patients achieved adequate engraftment and showed improvement in their clinical and immunologic findings. Atopic dermatitis and food allergies improved in all patients, and their dietary restriction was stopped except one patient who was transplanted recently. The frequency of infections was decreased. The overall survival is 91% in HSCT‐received patients and 80% in all. HSCT at the earliest possible period with most suitable donor‐ and patient‐specific appropriate conditioning regimen and GvHD prophylaxis is lifesaving for DOCK8 deficiency cases.
Special management considerations for propranolol use in breastfed infants of mothers taking antihypertensives
Authors: Aizman Leora , Van Den Anker John , Tender Jennifer , Krishnan Anita , Kirkorian Anna Yasmine
Published: February 2020

Propranolol is approved for treatment of infantile hemangiomas (IH). IH proliferation coincides with the time when most women are breastfeeding, yet there are no reports describing the clinical effects on infants treated with propranolol while being nursed by mothers on oral antihypertensive medications. We describe two cases of breastfed infants, with mothers taking multiple antihypertensives of different drug classes, who were initiated on propranolol for IH treatment and discuss the theoretical risk of propranolol use in this setting.
Adjuvants that Empower the Action of Photodynamic Therapy
Authors: Ortel Bernhard , Jabeen Shakeela , Greer Alexander
Published: February 2020

Compounds have been devised whose supportive actions make them important adjuvants in the priming of photosensitization to selectively target cancer cells. Here, we highlight the paper by Maytin and Hasan in this issue of Photochemistry & Photobiology, which describes adjuvants methotrexate, 5‐fluorouracil, vitamin D and its analogs leading to improved photodynamic therapy outcome. These small molecule adjuvants act by different mechanisms to enhance the cytotoxicity in tumor cells and the therapeutic effect in cancers. These findings add to the list of strategies for enhancement of photodynamic therapy.
Nickel potentiates soybean resistance against infection by Phakopsora pachyrhizi
Authors: Einhardt Andersom Milech , Ferreira Sandro , Hawerroth Caroline , Valadares Samuel Vasconcelos , Rodrigues Fabricio Ávila
Published: February 2020

Asian soybean rust (ASR), caused by the fungus Phakopsora pachyrhizi, causes significant yield losses worldwide. Nickel (Ni) plays a key role in the metabolism of some profitable crops, such as soybeans, because it is a constituent of several biomolecules and is required for the catalytic process of several enzymes. This study investigated the effect of foliar Ni treatment on the potentiation of soybean cultivar TMG 135 resistance to P. pachyrhizi infection at the microscopic, biochemical, and molecular levels. The severity of ASR decreased by 35% in plants treated with Ni. The malondialdehyde concentration, an indicator of cellular oxidative damage, was high in the leaves of plants that were not treated with Ni and was linked to ASR severity and the extensive colonization of the palisade and spongy parenchyma cells by fungal hyphae. The lignin concentration, β‐1,3‐glucanase activity, and expression of the URE gene and the defence‐related genes PAL1.1, PAL2.1, CHI1B1, and PR‐1A were up‐regulated in Ni‐treated plants infected with P. pachyrhizi. The information provided by this study shows the great potential of Ni to increase the basal level of soybean resistance to ASR and to complement other control methods within the context of sustainable agriculture.
Reasoning's relation to bodily action
Authors: Jenkins David
Published: February 2020

Recent philosophical work on the relation between reasoning and bodily action is dominated by two views. It is orthodox to have it that bodily actions can be at most causally involved in reasoning. Others have it that reasoning can constitutively involve bodily actions, where this is understood as a matter of non‐mental bodily events featuring as constituents of practical reasoning. Reflection on cases of reasoning out‐loud suggests a neglected alternative on which both practical and theoretical reasoning can have bodily actions as constituents, where such bodily actions themselves amount to contentful mental events. Furthermore, the natural lines of resistance to this view trade on type‐token errors, or on a questionable common‐factor assumption.
Framing Agri‐Digital Governance: Industry Stakeholders, Technological Frames and Smart Farming Implementation
Authors: Higgins Vaughan , Bryant Melanie
Published: February 2020

Meso‐scale actors – such as farm advisors and other extension agents – are increasingly recognised as playing a critical role in managing farmer uncertainty associated with smart farming implementation. However, there has been limited research to date on how these actors navigate smart farming implementation within specific industries or commodity sectors. This article applies theoretical insights from the technological frames literature to investigate how meso‐scale actors in the Australian rice industry frame smart farming technology implementation, and the ways in which relationships between frames variously afford and/or constrain industry sovereignty over implementation of technological change. Through analysis of our data, we reveal a complex relationship between participants’ technological frames involving frame incongruence, frame ambivalence and frame switching. We argue that while development of a more integrated approach to enhancing the digital capacities of meso‐scale actors advocated in the literature provides a way of addressing frame incongruence, more flexible strategies may be needed to address frame ambivalence and switching. Furthermore, we contend that those frame relationships supporting industry sovereignty – namely frame ambivalence and switching – may not always be conducive to the promotion of digital agency among meso‐scale actors, and could in fact impose limits on smart farming implementation.
Effects of Time-Varying Mass on Stability of High-Voltage Conductor in Rain–Wind Condition
Authors: Zhou Chao , Yin Jiaqi
Published: February 2020

Although unanticipated low-frequency vibrations frequently happen on high-voltage conductors under the simultaneous occurrence of wind and rain, the source of these vibrations is not well known. Many studies focus on the impact of rain loads on the high-voltage conductor but very few examine the effects of time-varying mass. Raindrops hitting high-voltage conductors may partially stay on their surface and form rivulets or ridges. As the adhered raindrops may be blown or shaken off, the mass of the rivulets will vary with time. In order to investigate how the time-varying mass of the rivulets affects conductor motion, an analytical model with time-varying mass is established, which leads to the statement of an instability criterion. The vibration characteristics and instability of a high-voltage conductor with fixed and movable rivulet are discussed. The results show that the time-varying mass ratio may affect the peak vibration amplitude, and the unstable zone of the conductor with moveable upper rivulet is much wider than that with fixed upper rivulet, and the rain–wind-induced vibration occurs more easily than Den Hartog galloping. Such comparative studies may prove valuable as they enhance the understanding of the mechanism of the rain–wind induced instability of the high-voltage conductors.
Effects of Electropulsing Treatment on the Element Diffusion Between Ti6Al4V and Commercially Pure Titanium
Authors: Li Xia’nan , Xu Zhutian , Huang Jihui , Peng Linfa , Guo Ping
Published: February 2020

Previous studies show that the phase transition temperature of Ti6Al4V can be effectively reduced by electropulsing treatment, which may be related to the promotion effect of current on element diffusion. In order to verify the above conjecture, the diffusion experiments of the Ti6Al4V-pure titanium system under the action of electropulsing and heat treatment are carried out. The results show that the current can effectively improve the diffusion coefficients of aluminum and vanadium, and the promotion effect has no relationship with the direction of the current. Considering the inhomogeneity of the Joule heat distribution of the microscopic scale of the material, the hypothesis of “local hot spot” is proposed to explain the experimental phenomena. It is found that the hypothesis can make effective predictions of diffusion coefficients and explain the promotion effect of electropulsing on Ti6Al4V phase transition reasonably.
Nonlinear Dynamic Analysis of a Trochoid Cam Gear
Authors: Yang Ronggang , Han Bo , Li Fengping , Zhou Yuqing , Xiang Jiawei
Published: February 2020

A trochoid cam gear (TCG) is a kind of precise transmission device with high performance, such as non-backlash, high-precision, low noise, etc. However, the nonlinear dynamics has not been studied. In the present paper, the nonlinear dynamic differential equation of the TCG is constructed. First, the trochoid equation and the tooth profile equation are deduced to satisfy the conditions of the continuous transmission. Second, a pure torsional nonlinear dynamic model is established to further construct the nonlinear model of the TCG according to a Lagrange equation. Finally, the dynamic characteristics of the TCG are investigated. For the short amplitude coefficient K, break of quasiperiodic torus is the main reason for the chaotic vibration. By increasing K, the performance of TCG can be improved to maintain stable motion.
Mechanical Design and Performance Analysis of a Novel Parallel Robot for Ankle Rehabilitation
Authors: Li Jianfeng , Zuo Shiping , Zhang Leiyu , Dong Mingjie , Zhang Zikang , Tao Chunjing , Ji Run
Published: February 2020

As the population ages, increasingly more individuals experience ankle disabilities caused by stroke and cerebral palsy. Studies on parallel robots for ankle rehabilitation have been conducted under this circumstance. This paper presents a novel parallel ankle rehabilitation robot with the key features of a simple configuration and actuator nonredundancy. The mechanical design is determined, and a prototype is built. Additionally, inverse position solution is addressed to calculate the workspace of the parallel robot. Jacobian matrices mapping the velocity and force from the active joint space to the task space are derived, and kinetostatic performance indices, namely, motion isotropy, force transfer ratio, and force isotropic radius are defined. Moreover, the inverse dynamic model is presented using the Newton–Euler formulation. Dynamic evaluation index, i.e., dynamic uniformity, is proposed according to the derived Jacobian matrix and inertia matrix. Based on the workspace analysis, the parallel robot demonstrates a sufficient workspace for ankle rehabilitation compared with measured range of motion of human ankle joint complex. The results of the kinetostatic and dynamic performance analysis indicate that the parallel robot possesses good motion isotropy, high force transfer ratio, large force isotropic radius, and relatively uniform dynamic dexterity within most of the workspace, especially in the central part. A numerical example is presented to simulate the rehabilitation process and verify the correctness of the inverse dynamic model. The simplicity and the performance of the proposed robot indicate that it has the potential to be widely used for ankle rehabilitation.
New Insight on Motor Behavior: The Link Between the Hopping Task and the Tracing Performance as Hint of Gross and Fine Motor Functions
Authors: Bondi Danilo , Di Sano Sergio , Verratti Vittore , Neri Giampiero , Aureli Tiziana , Pietrangelo Tiziana
Published: February 2020

The gross motor coordination tasks are thought to be likely not linked to the fine motor coordination tasks. The authors aimed to investigate this matter through a network analysis linking graphomotor (by tablet PC tracing), gross coordination (by Körperkoordinationstest für Kinder items), and strength (by handgrip) parameters in school children. Interestingly, the authors found that “Hopping” was the strongest central node, with linkages to “Quality” and “Speed” on tracing test. Handgrip strength did not link to gross coordination and graphomotor parameters, except with “Pressure.” Graphomotor performances suggested substantial peculiarities in developmental trajectories. Sport participation did not influence gross coordination nor graphomotor performances. The authors suggest considering the functional link between hopping and graphomotricity both in planning physical education and in understanding coordination impairments, through the developmental trajectories.
Insecticidal Activity of Doxycycline against the Common Bedbug
Authors: Pietri Jose E. , Liang Dangsheng
Published: February 2020

There is an ongoing need for safe and effective anti-bedbug compounds. Here, we tested the toxicity of three antimicrobial agents against bedbugs when administered orally. We reveal that doxycycline has direct insecticidal activity at 250 μg/ml (0.025%) that is particularly strong against immature bedbugs and appears to be independent of antimicrobial activity. Future studies to determine the mechanisms behind this property could be useful for the development of orally active insecticides or anti-bedbug therapeutics.
Endovascular repair of spontaneous popliteal artery pseudoaneurysm
Authors: Belczak Sergio Quilici , Góes Leonardo Garcia , Stefaniak Vanessa
Published: February 2020

Popliteal artery pseudoaneurysms are rare and are generally associated with local trauma, such as orthopaedic surgery or expansile bone lesions in the popliteal fossa. The authors describe a case of popliteal artery pseudoaneurysm in a 24-year-old man. A thorough workup revealed no history of trauma, invasive procedures, vasculitis or any other factors that could constitute a probable cause of the pseudoaneurysm. However, as the patient practices running, it is not possible to rule out minor previous trauma that has not been noticed.
Intractable pleural effusion in Kaposi sarcoma following antiretroviral therapy in a Caucasian female infected with HIV
Authors: Tajarernmuang Pattraporn , Fiset Pierre-Olivier , Routy Jean-Pierre , Beaudoin Stéphane
Published: February 2020

We report the case of a 57-year-old Caucasian woman with AIDS-related disseminated Kaposi sarcoma (KS) characterised by the combination of several unusual features. The chylous nature of the pleural effusions, the documented parietal pleural involvement at thoracoscopy and the marked clinical worsening through an immune reconstitution syndrome following antiretroviral therapy initiation represent several rare situations that occurred in the same female patient. In addition, the use of indwelling pleural catheters for dyspnoea palliation also represents a rare therapeutic intervention. This case is a reminder of the possibility of AIDS-related pleural KS, now uncommon in the era of antiretroviral therapy.
Outcome measurement in functional neurological disorder: a systematic review and recommendations
Authors: Pick Susannah , Anderson David G , Asadi-Pooya Ali A , Aybek Selma , Baslet Gaston , Bloem Bastiaan R , Bradley-Westguard Abigail , Brown Richard J , Carson Alan J , Chalder Trudie , Damianova Maria , David Anthony S , Edwards Mark J , Epstein Steven A , Espay Alberto J , Garcin Béatrice , Goldstein Laura H , Hallett Mark , Jankovic Joseph , Joyce Eileen M , Kanaan Richard A , Keynejad Roxanne C , Kozlowska Kasia , LaFaver Kathrin , LaFrance, Jr. W Curt , Lang Anthony E , Lehn Alex , Lidstone Sarah , Maurer Carine W , Mildon Bridget , Morgante Francesca , Myers Lorna , Nicholson Clare , Nielsen Glenn , Perez David L , Popkirov Stoyan , Reuber Markus , Rommelfanger Karen S , Schwingenshuh Petra , Serranova Tereza , Shotbolt Paul , Stebbins Glenn T , Stone Jon , Tijssen Marina AJ , Tinazzi Michele , Nicholson Timothy R
Published: February 2020

Objectives

We aimed to identify existing outcome measures for functional neurological disorder (FND), to inform the development of recommendations and to guide future research on FND outcomes.

Methods

A systematic review was conducted to identify existing FND-specific outcome measures and the most common measurement domains and measures in previous treatment studies. Searches of Embase, MEDLINE and PsycINFO were conducted between January 1965 and June 2019. The findings were discussed during two international meetings of the FND-Core Outcome Measures group.

Results

Five FND-specific measures were identified—three clinician-rated and two patient-rated—but their measurement properties have not been rigorously evaluated. No single measure was identified for use across the range of FND symptoms in adults. Across randomised controlled trials (k=40) and observational treatment studies (k=40), outcome measures most often assessed core FND symptom change. Other domains measured commonly were additional physical and psychological symptoms, life impact (ie, quality of life, disability and general functioning) and health economics/cost–utility (eg, healthcare resource use and quality-adjusted life years).

Conclusions

There are few well-validated FND-specific outcome measures. Thus, at present, we recommend that existing outcome measures, known to be reliable, valid and responsive in FND or closely related populations, are used to capture key outcome domains. Increased consistency in outcome measurement will facilitate comparison of treatment effects across FND symptom types and treatment modalities. Future work needs to more rigorously validate outcome measures used in this population.
Understanding the musculoskeletal injury risk of women in combat: the effect of infantry training and sex on musculoskeletal injury incidence during British Army basic training
Authors: O'Leary Thomas J , Wardle S L , Rawcliffe A J , Chapman S , Mole J , Greeves J P
Published: February 2020

Introduction

Until recently, women were excluded from British combat roles. Their risk for musculoskeletal injury during basic training is two to three times higher than men. To better understand the musculoskeletal injury risk of women in British Army infantry basic training, we compared injury incidence between (1) men in standard entry training and men in infantry training, to assess the risk of infantry training; and (2) men and women in both standard entry and officer basic training, to assess the risk in women compared with men.

Methods

The incidence of musculoskeletal injury was determined from defence medical records for all men entering infantry training, and for all men and women entering standard entry and officer training, between April 2015 and March 2016.

Results

7390 men (standard entry, n=4229; infantry, n=2683; officer, n=478) and 696 women (standard entry, n=626; officer, n=70) entered basic training. Men in infantry training had a lower incidence of musculoskeletal injury (391 vs 417 per 1000 personnel, OR 0.90 (95% CI 0.81 to 0.99), p=0.028) and a higher incidence of stress fracture (14 vs 5 per 1000 personnel, OR 2.80 (95% CI 1.64 to 4.80), p<0.001) than men in standard entry training. Women had a higher incidence of musculoskeletal injury than men in standard entry training (522 vs 417 per 1000 personnel, OR 1.53 (95% CI 1.29 to 1.81), p<0.001) and a higher incidence of stress fracture than men in officer training (114 vs 19 per 1000 personnel, OR 6.72 (95% CI 2.50 to 18.07), p<0.001).

Conclusion

Women in infantry training may be at similar risk for musculoskeletal injury, but at higher risk for stress fracture, compared with their non-infantry counterparts. Women in infantry training may be at higher risk for musculoskeletal injury and stress fracture compared with men in infantry training.
Dental anatomy of the apex predator Sinraptor dongi (Theropoda: Allosauroidea) from the Late Jurassic of China
Authors: Hendrickx Christophe , Stiegler Josef , Currie Philip J. , Han Fenglu , Xu Xing , Choiniere Jonah N. , Wu Xiao-Chun
Published: February 2020

The dental morphology of the holotype of the theropod Sinraptor dongi from the Jurassic Shishugou Formation of China is comprehensively described. We highlight a combination of dental features that appear to be restricted to Sinraptor: (i) crowns with denticulated mesial and distal carinae extending from the root and an irregular surface texture on the enamel; (ii) a D- to salinon-shaped cross-sectional outline at the crown base in mesialmost teeth; (iii) mesial crowns with mesial carinae spiraling mesiolingually and lingually positioned longitudinal groove adjacent to the mesial carina; and (iv) particularly labiolingually compressed lateral teeth with weakly labially deflected distal carinae, flat to concave basocentral surfaces of the labial margins of the crowns, and horizontally elongated distal denticles showing short to well-developed interdenticular sulci. Using cladistic, multivariate, discriminant, and cluster analyses, we demonstrate that the dentition of Sinraptor is relatively similar to that of ceratosaurids, megalosauroids, and other allosauroids and is particularly close to that of Allosaurus. The dental anatomy of Sinraptor and Allosaurus, which differs mainly in the labiolingual compression of the lateral crowns and in the number of premaxillary teeth, shows adaptations towards a predatory lifestyle, including premaxillary teeth capable of enduring tooth-to-bone contact and crowns with widely separated mesial and distal carinae capable of inflicting widely open wounds.
Linking hydrocarbon biodegradation to greenhouse gas emissions from oil sands tailings and its impact on tailings management
Authors: Siddique Tariq , Kuznetsova Alsu
Published: February 2020

Microbial research for maintaining soil productivity, health, and environment as well as for ecosystem function has been one of the main research focuses in the Department of Renewable Resources (formerly Department of Soil Science) during the last 100 yr. In recent years, microbial research has been expanded to effectively reclaim disturbed land, remediate contaminated sites, and manage soft sediments such as huge volumes of oil sands tailings. This article highlights the microbial processes in tailings ponds that can affect strategies to manage growing inventory of oil sands tailings and reduce associated environmental footprint. Enormous volumes of fluid fine tailings produced during bitumen extraction from oil sands are retained in tailings ponds. Some tailings streams contain residual labile hydrocarbons originated from the hydrocarbon solvents used in the extraction process. Indigenous microorganisms acclimated to the pond environment metabolize certain fractions of the fugitive labile hydrocarbons into biogenic greenhouse gases (GHG) such as methane (CH4) and carbon dioxide (CO2). Long-term (1–7 yr) biodegradation studies conducted using mature fine tailings (MFT) collected from different tailings ponds reveal that the microorganisms sequentially and preferentially biodegrade hydrocarbons under methanogenic conditions. The stoichiometric mathematical model developed on these biodegradation studies can predict GHG emissions from tailings ponds. Production of biogenic gases also affects the porewater and solid-phase chemistry of MFT and accelerates their de-watering and consolidation during active methanogenesis, which is beneficial for recovery of porewater for reuse in the bitumen extraction process and for effective reclamation of consolidated material.
Comprehensive and Systematic Study on the Fault Tolerance Architectures in Cloud Computing
Authors: Mohammadian Vahid , Navimipour Nima Jafari , Hosseinzadeh Mehdi , Darwesh Aso
Published: February 2020

Providing dynamic resources is based on the virtualization features of the cloud environment. Cloud computing as an emerging technology uses a high availability of services at any time, in any place and independent of the hardware. However, fault tolerance is one of the main problems and challenges in cloud computing. This subject has an important effect on cloud computing, but, as far as we know, there is not a comprehensive and systematic study in this field. Accordingly, in this paper, the existing methods and mechanisms are discussed in different groups, such as proactive and reactive, types of fault detection, etc. Various fault tolerance techniques are provided and discussed. The advantages and disadvantages of these techniques are shown on the basis of the technology that they have used. Generally, the contributions of this research provide a summary of the available challenges associated with fault tolerance, a description of several important fault tolerance methods in the cloud computing and the key regions for the betterment of fault tolerance techniques in the future works. The advantages and disadvantages of the selected articles in each category are also highlighted and their significant challenges are discussed to provide the research lines for further studies.
Layered-tunnel structured cathode for high performance sodium-ion batteries
Authors: Zan Feng , Yao Yao , Savilov Serguei V. , Suslova Eugenia , Xia Hui
Published: February 2020

Sodium-ion batteries (SIBs) are promising candidates for large-scale energy storage applications. High-performance cathode material with high-energy density and long cycle life is of great interest. Here, an F-doped Nax[Formula: see text]Fy with layered-tunnel intergrowth structure is synthesized by a facile solid-state reaction method. The microstructure and composition of prepared material was confirmed by X-ray diffraction, field emission scanning electron microscope and transmission electron microscopy. The aim of the structure design is to combine the complementary features of high capacity from P2 phase and excellent structural stability from tunnel phase, as well as to improve rate performance by F doping. When investigated as high-rate and long-life cathode materials for Na-ion batteries, the layered-tunnel intergrowth structure exhibits synergistic effect including high discharge capacity (194.0[Formula: see text]mAh[Formula: see text][Formula: see text]), good rate capability (86[Formula: see text]mAh[Formula: see text][Formula: see text] at 15 C) as well as good cycling stability (81.2% capacity retention after 100 cycles). The as-prepared layered-tunnel intergrowth Nax[Formula: see text]Fy provides new insight into the development of intergrowth electrode materials and their application in rechargeable SIBs.
Intelligent Intersection
Authors: Huang Xiaohui , He Pan , Rangarajan Anand , Ranka Sanjay
Published: February 2020

Camera-based systems are increasingly used for collecting information on intersections and arterials. Unlike loop controllers that can generally be only used for detection and movement of vehicles, cameras can provide rich information about the traffic behavior. Vision-based frameworks for multiple-object detection, object tracking, and near-miss detection have been developed to derive this information. However, much of this work currently addresses processing videos offline. In this article, we propose an integrated two-stream convolutional networks architecture that performs real-time detection, tracking, and near-accident detection of road users in traffic video data. The two-stream model consists of a spatial stream network for object detection and a temporal stream network to leverage motion features for multiple-object tracking. We detect near-accidents by incorporating appearance features and motion features from these two networks. Further, we demonstrate that our approaches can be executed in real-time and at a frame rate that is higher than the video frame rate on a variety of videos collected from fisheye and overhead cameras.
Large-Scale Question Tagging via Joint Question-Topic Embedding Learning
Authors: Nie Liqiang , Li Yongqi , Feng Fuli , Song Xuemeng , Wang Meng , Wang Yinglong
Published: February 2020

Recent years have witnessed a flourishing of community-driven question answering (cQA), like Yahoo! Answers and AnswerBag, where people can seek precise information. After 2010, some novel cQA systems, including Quora and Zhihu, gained momentum. Besides interactions, the latter enables users to label the questions with topic tags that highlight the key points conveyed in the questions. In this article, we shed light on automatically annotating a newly posted question with topic tags that are predefined and preorganized into a directed acyclic graph. To accomplish this task, we present an end-to-end deep interactive embedding model to jointly learn the embeddings of questions and topics by projecting them into the same space for a similarity measure. In particular, we first learn the embeddings of questions and topic tags by two deep parallel models. Thereinto, we regularize the embeddings of topic tags via fully exploring their hierarchical structures, which is able to alleviate the problem of imbalanced topic distribution. Thereafter, we interact each question embedding with the topic tag matrix, i.e., all the topic tag embeddings. Following that, a sigmoid cross-entropy loss is appended to reward the positive question-topic pairs and penalize the negative ones. To justify our model, we have conducted extensive experiments on an unprecedented large-scale social QA dataset obtained from Zhihu.com, and the experimental results demonstrate that our model achieves superior performance to several state-of-the-art baselines.
Endogenous Opioids at the Intersection of Opioid Addiction, Pain, and Depression: The Search for a Precision Medicine Approach
Authors: Emery Michael A. , Akil Huda
Published: February 2020

Opioid addiction and overdose are at record levels in the United States. This is driven, in part, by their widespread prescription for the treatment of pain, which also increased opportunity for diversion by sensation-seeking users. Despite considerable research on the neurobiology of addiction, treatment options for opioid abuse remain limited. Mood disorders, particularly depression, are often comorbid with both pain disorders and opioid abuse. The endogenous opioid system, a complex neuromodulatory system, sits at the neurobiological convergence point of these three comorbid disease states. We review evidence for dysregulation of the endogenous opioid system as a mechanism for the development of opioid addiction and/or mood disorder. Specifically, individual differences in opioid system function may underlie differences in vulnerability to opioid addiction and mood disorders. We also review novel research, which promises to provide more detailed understanding of individual differences in endogenous opioid neurobiology and its contribution to opioid addiction susceptibility.
Suitability of the Hanging Meniscus RDE for the Electrochemical Investigation of Ionic Liquids
Authors: Wippermann K. , Suo Y. , Korte C.
Published: February 2020

Employing the oxygen reduction reaction (ORR) exemplarily, the suitability of the hanging meniscus RDE (HMRDE) technique for viscous electrolytes—in particular for ionic liquids—was examined. RDE and HMRDE experiments were carried out using polycrystalline Pt disks in contact with either concentrated phosphoric acid, N,N-diethylmethylammoniumtriflate ([Dema][TfO]) or 2-sulfoethylmethyl-ammoniumtriflate ([2-Sema][TfO]). RDE measurements revealed Levich factors of the oxygen transport close to the theoretical value, even if the thickness of the hydrodynamic layer was about ⅔ of the disk diameter. HMRDE experiments showed a pronounced scattering of the Levich factors, which means a significant error in the determination of the mass transport parameters. In contrast, reliable Tafel factors of ORR were obtained from HMRDE experiments with viscous mixtures of [2-Sema][TfO] and water. The thickness of the perturbed layer δ
pl near the edge of the HMRDE was found to be virtually independent of the viscosity of the respective electrolyte. In the case of viscous electrolytes like ionic liquids, the HMRDE technique is particularly suitable for investigating the kinetic parameters of electrochemical processes at elevated temperatures >100 °C, whereas a more precise determination of mass transport properties will only be possible once the experimental error can be significantly reduced.
Plastic Crystals Utilising Small Ammonium Cations and Sulfonylimide Anions as Electrolytes for Lithium Batteries
Authors: Yunis Ruhamah , Al-Masri Danah , Hollenkamp Anthony F. , Doherty Cara M. , Zhu Haijin , Pringle Jennifer M.
Published: February 2020

Organic ionic plastic crystals (OIPCs) are increasingly promising as a class of solid-state electrolyte for developing safer lithium batteries. However, their advancement relies on expanding the range of well-characterised cation/anion combinations. Here, we report the synthesis and characterization of OIPCs utilising small ammonium cations tetramethylammonium ([N1111]+), triethylmethylammonium ([N1222]+) and tetraethylammonium ([N2222]+), chosen to encourage significant rotational and translational motion, with the charge-diffuse and electrochemically stable bis(fluorosulfonyl)imide ([FSI]ˉ) and bis(trifluoromethanesulfonyl)imide ([NTf2]ˉ) anions. To investigate the physico-chemical properties of the OIPCs, the free volume was measured by positron annihilation spectroscopy (PALS) and correlated with the ionic conductivity and thermal analysis (DSC). Solid-state NMR analysis of the salts, is also reported. The salts with the less symmetric cation, [N1222][FSI] and [N1222][NTf2], were identified as the most promising electrolyte materials, and thus the electrochemical properties after mixing with 10 and 90 mol% lithium bis(fluorosulfonyl)imide (LiFSI) or lithium bis(trifluoromethanesulfonyl)imide (LiNTf2), respectively, were investigated. This study demonstrates the efficacy of these OIPC materials as new quasi-solid state electrolytes with advantageous properties such as high conductivity, good thermal and electrochemical properties, the ability to incorporate high lithium salt concentrations and support efficient lithium electrochemistry.
Review—Recent Advances in Electrochemical Impedance Spectroscopy Based Toxic Gas Sensors Using Semiconducting Metal Oxides
Authors: Balasubramani V. , Chandraleka S. , Rao T. Subba , Sasikumar R. , Kuppusamy M. R. , Sridhar T. M.
Published: February 2020

Electrochemical Impedance Spectroscopy (EIS) in the past few years has been used to design gas sensors. EIS based gas sensing has been considered as an ultra-sensitive technique to identify and measure different toxic gases. Their sensing performance has been superior when compared to other conventional techniques. Impedance makes it possible to investigate the finer changes occurring on the surface of sensing layers leading to the identification of the target gases such as H2S. The measurements are carried out by scanning the electrode surface with a mixture of frequencies from 1 Hz to 10 MHz and recording the response as Nyquist and Bode plots. From these plots, the results can be used to elucidate the electrochemical phenomena. The acquired impedance data can be fitted into equivalent circuits and this is further modeled to obtain information about the interfacial phenomena like grain bulk resistance, grain boundary resistance, interface between electrode and sensing film resistance. These phenomena support the sensing of toxic gases from ppm - ppb level. This article focuses on impedance spectroscopy and its relevance to sensors, challenges in detecting toxic gases on the electrode surfaces prepared using semiconducting metal oxides, doped metal oxides and graphene based composites along with the research gaps, current innovations and future directions. EIS based gas sensors have high selectivity, sensitivity, reproducibility, long term stability and they also assist prediction of the electrochemical mechanisms for the analyte gases.
Power Ultrasonic Additive Manufacturing: Process Parameters, Microstructure, and Mechanical Properties
Authors: Gujba Abdullahi K. , Medraj Mamoun
Published: February 2020

Additive manufacturing (AM) for fabricating 3D metallic parts has recently received considerable attention. Among the emerging AM technologies is ultrasonic additive manufacturing (UAM) or ultrasonic consolidation (UC), which uses ultrasonic vibrations to bond similar or dissimilar materials to produce 3D builds. This technology has several competitive advantages over other AM technologies, which includes fabrication of dissimilar materials and complex shapes, higher deposition rate, and fabrication at lower temperatures, which results in no material transformation during processing. Although UAM process optimization and microstructure have been reported in the literature, there is still lack of standardized and satisfactory understanding of the mechanical properties of UAM builds. This could be attributed to structural defects associated with UAM processing. This article discusses the effects of UAM process parameters on the resulting microstructure and mechanical properties. Special attention is given to hardness, shear strength, tensile strength, fatigue, and creep measurements. Also, pull‐out, push‐out, and push‐pin tests commonly employed to characterize bond quality and strength have been reviewed. Finally, current challenges and drawbacks of the process and potential applications have been addressed.
Nε-Carboxymethyl-Lysine Negatively Regulates Foam Cell Migration via the Vav1/Rac1 Pathway
Authors: Bao Zhengyang , Zhang Lili , Li Lihua , Yan Jinchuan , Pang Qiwen , Sun Zhen , Geng Yue , Jing Lele , Shao Chen , Wang Zhongqun
Published: February 2020

Background. Macrophage-derived foam cells play a central role in atherosclerosis, and their ultimate fate includes apoptosis, promotion of vascular inflammation, or migration to other tissues. Nε-Carboxymethyl-lysine (CML), the key active component of advanced glycation end products, induced foam cell formation and apoptosis. Previous studies have shown that the Vav1/Rac1 pathway affects the macrophage cytoskeleton and cell migration, but its role in the pathogenesis of diabetic atherosclerosis is unknown. Methods and Results. In this study, we used anterior tibiofibular vascular samples from diabetic foot amputation patients and accident amputation patients, and histological and cytological tests were performed using a diabetic ApoE-/- mouse model and primary peritoneal macrophages, respectively. The results showed that the atherosclerotic plaques of diabetic foot amputation patients and diabetic ApoE-/- mice were larger than those of the control group. Inhibition of the Vav1/Rac1 pathway reduced vascular plaques and promoted the migration of macrophages to lymph nodes. Transwell and wound healing assays showed that the migratory ability of macrophage-derived foam cells was inhibited by CML. Cytoskeletal staining showed that advanced glycation end products inhibited the formation of lamellipodia in foam cells, and inhibition of the Vav1/Rac1 pathway restored the formation of lamellipodia. Conclusion. CML inhibits the migration of foam cells from blood vessels via the Vav1/Rac1 pathway, and this process affects the formation of lamellipodia.
An Improved Equation for Predicting Compressive Stress in Posttensioned Anchorage Zone
Authors: Park Young-Ha , Kim Moon-Young , Park Jong-Myen , Jeon Se-Jin
Published: February 2020

Validity of the approximate equation for predicting compressive stress in the posttensioned anchorage zone presented in the AASHTO LRFD Bridge Design Specifications was investigated in this study. Numerical analysis based on the finite element method (FEM) and theoretical analysis showed that the AASHTO formula gives relatively accurate stress values when the effect of duct holes is neglected. However, it was found that the formula can significantly overestimate the stresses in the actual prestressed concrete member with spaces occupied by ducts. Therefore, an improved equation was proposed for the existing AASHTO equation to consider the effect of the duct holes on the stress distribution. This resulted in relatively accurate prediction of the distribution and magnitude of the compressive stresses even with the presence of the duct holes. The proposed equation was also validated by comparing with the stresses measured in the test of a posttensioned full‐scale specimen. This study is expected to contribute to the design of the anchorage zone in prestressed concrete structures by suggesting a more reasonable way to assess the appropriateness of anchorage devices.
Oncological Treatment Considerations Differ across Surgical Subspecialties Treating Malignant Peripheral Nerve Sheath Tumors: An International Survey
Authors: Martin Enrico , Slooff Willem-Bart M. , van Houdt Winan J. , van Dalen Thijs , Verhoef Cornelis , Coert J. Henk
Published: February 2020

Background. Malignant peripheral nerve sheath tumors (MPNSTs) are rare and aggressive soft tissue sarcomas (STS) that, because of their origin, are operated by several surgical subspecialties. This may cause differences in oncologic treatment recommendations based on presentation. This study investigated these differences both within and between subspecialties. Methods. A survey was distributed among several (inter)national surgical societies. Differences within and between subspecialties were analyzed by χ2-tests. Results. In total, 30 surgical oncologists, 30 neurosurgeons, 85 plastic surgeons, and 29 “others” filled out the survey. Annual caseload, tumor sites operated, and fellowship training differed significantly between subspecialties. While most surgeons agreed upon preoperative use of MRI, the use of radiological staging and FDG-PET use differed between subspecialties. Surgical oncologists agreed upon core needle biopsies as an ideal type of biopsy while other subspecialties differed in opinion. On average, 53% of surgeons always consider preservation of function preoperatively, but 42% would never perform less extensive resections for function preservation. Respondents agreed that radiotherapy should be considered in tumor sizes >10 cm, microscopic, and macroscopic positive margins. A preferred sequence of radiotherapy administration differed between subspecialties. There was no consensus on indications and sequence of administration of chemotherapy in localized disease. Conclusion. Surgical oncologists generally agree on preoperative diagnostics; other subspecialties do not. Considering the preservation of function differed among all subspecialties. Surgeons do agree on some indications for radiotherapy, yet the use of chemotherapy in localized MPNSTs lacks consensus. A preferred sequence of multimodal therapy differs between and within surgical subspecialties, but surgical oncologists prefer neoadjuvant radiotherapy.
Morphology of the Vasculature and Blood Supply of the Brown Adipose Tissue Examined in an Animal Model by Micro‐CT
Authors: Mrzilkova J. , Michenka P. , Seremeta M. , Kremen J. , Dudak J. , Zemlicka J. , Musil V. , Minnich B. , Zach P.
Published: February 2020

We performed micro‐CT imaging of the vascular blood supply in the interscapular area of the brown adipose tissue in three mice with the use of intravascular contrast agent Aurovist™. Resulting 3D data rendering was then adapted into 2D resolution with visualization using false color system and grayscale images. These were then studied for the automatic quantification of the blood vessel density within this area. We found the highest most occurring density within arterioles or venules representing smaller blood vessels whereas with the increase of the vessel diameters a lower percentage rate of their presence was observed in the sample. Our study shows that micro‐CT scanning in combination with Aurovist™ contrast is suitable for anatomical studies of interscapular area of brown adipose tissue blood vessel supply.
The Inverse Solution Algorithm and Trajectory Error Analysis of Robotic Arm Based on MQACA-RBF Network
Authors: Cheng Xu , Zhao Ming
Published: February 2020

In order to improve the position accuracy and trajectory accuracy of a 6R robotic arm, a robot arm inverse solution algorithm based on the MQACA- (improved quantum ant colony-) RBF network is proposed. This algorithm establishes the prediction model through the neural network and uses the quantum ant colony algorithm to optimize the output weight. In order to solve the problem that the quantum ant colony algorithm has low convergence precision and easy to fall into the local optimal solution in the inverse solution algorithm of the multifreedom robotic arm, improved measures such as 2-opt local optimization and maximum minimum pheromone limit and variation are adopted. By comparing the simulation results of the 6R robotic arm simulation results and the simulation results based on ACA, QACA, and RBF neural networks on the position and motion trajectory of the space point, the advantages in precision are obvious. This proves the feasibility and effectiveness of the scheme.