bluuebunny/crossref_metadata_2025 huggingface dataset:
Design and Applications of Parathyroid Hormone Analogues
Authors: Morley Paul , F. Whitfield James , Willick Gordon E.
Published: April 2022

The endocrine parathyroid hormone (PTH) is the major regulator of serum calcium levels. In contrast, the autocrine/paracrine parathyroid hormone-related peptide (PTHrP) has been associated with organism development. Both are secreted as much larger molecules but have their major functions associated with their N-terminal 34 residues. They share a
common receptor expressed in organs critical to PTH function - bone, kidney, and intestine. PTH and PTHrP receptor activation stimulates adenylyl cyclase (AC), phospholipase C (PLC), and phospholipase D (PLD) in target cells. It has been possible to separate the AC-stimulation from that of PLC. AC-stimulation requires at least the N-terminal 28 residues of PTH and PLC­ stimulation requires a minimum of residues 29-32-NH2 . Intermittent administration of PTH
stimulates bone growth and requires AC-stimulation. The shortest linear sequence of hPTH with
essentially full anabolic activity for bone growth-stimulation is hPTH(1-31)NH2. Two applications are postulated for PTH and PTHrP-based pharmaceuticals - treatment of bone loss due to osteoporosis and reversal of the hypercalcemic effect of malignancy. PTHrP analogues which strongly inhibit PTHrP AC-stimulation showed promise for the treatment of malignancy­ associated hypercalcemia in animal trials but failed in human ones. However, both animal and
human trials of hPTH have shown significant bone growth-stimulating effects. New deletion,
substitution and cyclized analogues of PTH show great promise both for greater in vitro activity and possibly for improved delivery and greater specificity as agents for restoration of bone loss in osteoporosis.
The Palmitoylethanolamide and Oleamide Enigmas: Are These Two Fatty Acid Amides Cannabimimetic?
Authors: Lambert Didier M. , Di Marzo Vincenzo
Published: April 2022

Palmitoylethanolamide (PEA) and oleamide are two fatty acid amides which 1) share some cannabimimetic actions with L.9-tetrahydrocanna­
binol, anandamide and 2-arachidonoylglycerol, and 2) may interact with proteins involved in the biosynthesis, action and inactivation of endocannabinoids.

Palmitoylethanolamide (PEA) and oleamide are two fatty acid amides which 1) share some cannabimimetic actions with L.9-tetrahydrocanna­
binol, anandamide and 2-arachidonoylglycerol, and 2) may interact with proteins involved in the biosynthesis, action and inactivation of endocannabinoids.

Due to its pharmacological actions and its accumulation in damaged cells, PEA may have a physio-pathological role as an analgesic, anti-oxidant and anti-inflammatory mediator. However, its mechanism of action is puzzling. In fact, PEA does not bind to CB1 and CB2 receptors transfected into host cells, but might be a ligand for a putative CBn receptor present in the RBL-2H3 cell line. On the other hand, the analgesic effect of PEA is reversed by SR144528, a CB2 antagonist. PEA may act as an "entourage" compound for endocannabinoids, i.e. it may enhance their action for example by inhibiting their inactivation.

Oleamide is a sleep inducing lipid whose mechanism of action is far from being understood. Although it does not bind with high affinity to CB1 or CB2 receptors, it exhibits some cannabimimetic actions which could be explained at least in part by 'entourage' effects. It is likely that oleamide and anandamide have common as well as distinct pathways of action. The 5-HT2A receptor appears to be a target for oleamide but the possibility of the existence of specific receptors for this compound is open. The biosynthesis and tissue distribution of oleamide remain to be assessed in order to both substantiate its role as a sleep-inducing factor and
investigate its participation in other physiopathological situations.
Synthesis and Biological Evaluation of Hydroxypropyl Ester of Mefenamic
Acid as a Promising Prodrug
Authors: Jarrar Qais , Ayoub Rami , Moshawih Said , Jarrar Yazun , Jilani Jamal
Published: April 2022

Background:

The free carboxylic acid group in the mefenamic acid (MFA) structure plays a
potential role in developing various neuromuscular side effects after MFA administration. In this study,
the hydroxypropyl promoiety was added to the carboxylic acid group of MFA in an attempt to reduce the
neuromuscular side effects of MFA and improve its therapeutic effects.

Methods:

Hydroxypropylester of MFA (HPEMA) was synthesized and subjected to various in vivo investigations
compared to MFA. The neuromuscular toxicity was conducted following high doses administration
in mice and was evaluated at various measuring parameters, such as the percentage of catalepsy,
clonic-tonic seizure, and death. In addition, the anti-inflammatory and anti-nociceptive effects of HPEMA
were evaluated in the carrageenan-induced paw edema test and acetic acid-induced writhing test, respectively.

Results:

The findings of this study reveal that the percentage of catalepsy, clonic-tonic seizure, and death
is significantly lower in mice treated with HPEMA than in those treated with equimolar doses of MFA. In
addition, treatment with HPEMA caused a comparable anti-inflammatory activity in the carrageenaninduced
paw edema test and a significantly higher anti-nociceptive effect in the acetic acid-induced writhing
test than the MFA treatment.

Conclusion:

This study’s findings suggest that HPEMA is a promising prodrug for MFA.
State of the Art in Industrial Application of Amino-1,2,4-Triazoles
Authors: Nazarov Valerii , Miroshnichenko Denis , Ivakh Oleksandra , Pyshyev Serhiy , Korchak Bohdan
Published: April 2022

The review summarizes information on the industrial use of 3- and 4-amino-1,2,4-triazoles, the basic raw material for the industry of fine organic synthesis. A description of the existing production methods for the synthesis of 3- and 4-amino-1,2,4-triazoles and some methods of obtaining in laboratory conditions is given. Three main areas of use of these amines and their derivatives have been identified: agriculture, medicine, high-energy substances and gas-generating compositions. It has been shown that one of the earliest areas of widespread use of 3- and 4-amino-1,2,4-triazoles is the production of plant protection products. On their basis, the mass production of various insecticides, fungicides, plant growth regulators, retardants and inhibitors of nitrification of nitrogen fertilizers has been organized. The use of these amines in medicine consists in the production of known drugs on their basis, such as furazonal, thiotriazoline and cardiotril, which have hepatoprotective, antioxidant and anti-ischemic activity. The industrial processing of 3- and 4-amino-1,2,4-triazoles into explosives, solid propellants, propellants, and gas-generating compositions is a third well-known field of application. An explanation is given for the high reactivity of amines and the variety of areas of their use. A significant place in the review is occupied by the analysis of less known directions of use of the indicated aminotriazoles. These are: obtaining new types of salts and electrically conductive ionic liquids, corrosion inhibitors of non-ferrous metals and catalysts for the curing of epoxy resins. The results of recent studies are discussed, and the prospects for the use of 3- and 4-amino-1,2,4-triazoles as raw materials for the production of new reagents in analytical chemistry, proton-exchange membranes, and new condensed nitrogen-containing heterocycles are shown.
Odyssey of Deep Eutectic Solvents as Sustainable Media for Multicomponent Reactions: An Update
Authors: Chaudhary Ankita
Published: April 2022

Deep eutectic solvents (DESs) are frequently defined as binary or ternary mixtures of compounds that are able to associate mainly via hydrogen bonds. As the interest in green sustainable solvent’s spread over the entire scientific community, DESs find applications as alternative solvents and/or catalysts for organic transformations. Advantages such as easy reproducible preparation, low cost, environmentally benign nature, wide liquid range, excellent thermal stability, negligible vapour pressure, recyclability, and tunable properties render DESs as a sustainable candidate of catalyst/solvent for futuristic transformations involving multicomponent strategy. In view of the escalating demand for green synthetic approaches, this paper retrospects the advances made in the application of DES in multicomponent reactions since 2018.
Reinventing Plantain as a Functional Food: A Processing Based Approach
Authors: Rasane Prasad , Arora Mehak , Singh Jyoti , Kaur Sawinder , Bakshi Manish , Kaur Jaspreet
Published: April 2022

Plantains are termed as ‘culinary bananas’ due to the fact that they are only consumed
after cooking or other forms of processing. Providing good nutritional value and versatility in diet,
it is considered an important commercial crop and an efficient dietary staple in Africa. However,
irrespective of geographical locations and economic status of diverse ethnic groups, plantains
are consumed extensively due to their easy availability and preparation. They are prepared
and consumed in numerous forms between the green and yellow stages of maturity and ripeness.
The nutritional composition of plantains provides several health benefits and therapeutic applications,
making it preferable for consumption. They are processed for the further development of a
variety of products like biscuits, baby foods, bread, etc. The present review aims to enlist various
traditional dishes and the value-added products prepared from plantains after processing. It also
highlights other diverse uses of plantain where all the parts of the crop are functional and demonstrate
its potential in future scope.
A Concise Review on Tyrosine Kinase Targeted Cancer Therapy
Authors: Shah Ashish , Patel Chhagan , Parmar Ghanshaym , Patel Ashish , Jain Manav
Published: April 2022

The tyrosine kinase (TK) family is considered one of the important family members of the kinase family due to its important role in various cellular processes like cell growth, cell differentiation, apoptosis, etc. Mutation, overexpression, and dysfunction of tyrosine kinase receptors lead to the development of malignancy; thus, they are considered as one of the important targets for the development of anti-cancer molecules. The tyrosine kinase family is majorly divided into two classes; receptor and non-receptor tyrosine kinase. Both of the classes have an important role in the development of tumour cells. Currently, there are more than 40 FDA-approved tyrosine kinase inhibitors, which are used in the treatment of various types of cancers. Tyrosine kinase inhibitors mainly block the phosphorylation of tyrosine residue of the corresponding kinase substrate and so activation of downstream signalling pathways can be inhibited. The promising results of tyrosine kinase inhibitors in solid tumours provide a revolution in oncology research. In this article, we had summarized the role of some important members of the tyrosine kinase family in the development and progression of tumour cells and the significance of tyrosine kinase inhibitors in the treatment of various types of cancer.
Emerging Therapeutic Role of Chondroitinase (ChABC) in Neurological
Disorders and Cancer
Authors: Kolathur Kiran Kumar , Kumar Akshara , Biswas Aishi , Bojja Sree Lalitha , Volety Subrahmanyam M.
Published: April 2022

Proteoglycans are essential biomacromolecules that participate in matrix structure and organization,
cell proliferation and migration, and cell surface signal transduction. However, their roles
in physiology, particularly in CNS, remain incompletely deciphered. Numerous studies highlight the
elevated levels of chondroitin sulphate proteoglycans (CSPGs) in various diseases, like cancers, and
neurological disorders, like spinal cord injury (SCI), traumatic brain damage, neurodegenerative diseases,
and are mainly implicated to hinder tissue repair. In such a context, chondroitinase ABC
(ChABC), a therapeutic enzyme, has shown immense hope to treat these diseases in several preclinical
studies, primarily attributed to the digestion of the side chains of the proteoglycan chondroitin sulphate
(CS) molecule. Despite extensive research, the progress in evolution of the concept of therapeutic
targeting of proteoglycans is still in its infancy. This review thus provides fresh insights into the
emerging therapeutic applications of ChABC in various diseases apart from SCI and the underlying
mechanisms.
Promising Novel Biomarkers and Candidate Drugs or Herbs in Osteoarthritis:
Evidence from Bioinformatics Analysis of High‐throughput Data
Authors: Qiao Linghui , Han Jie , Wang Guancheng , Yuan Tao , Gu Yanglin
Published: April 2022

Background:

The most common joint illness is osteoarthritis (OA). The goal of this study
was to find changes in gene signatures between normal knee joints and OA tissue samples and look for
prospective gene targets for OA.

Methods:

The gene expression profiles of GSE12021, GSE51588, and GSE55457 were downloaded
from Gene Expression Omnibus (GEO). A total of 64 samples (40 OA and 24 standard control samples)
were used. The limma program was used to find differentially expressed genes (DEGs) in OA versus
NC. Functional annotation and protein-protein interaction (PPI) network construction of OA-specific
DEGs were performed. Finally, the candidate drugs and herbs as potential drugs to treat OA were predicted
in the DGIdb and TCMIO databases.

Results:

A total of 19 upregulated and 27 downregulated DEGs between OA and NC samples were
identified. DEGs, such as PTN, COMP, NELL1, and MN1, have shown a significant correlation with
OA and are expected to become new biomarkers. Cellular senescence, positive regulation of ossification,
and Vascular endothelial growth factor (VEGF) were significantly enriched for OA‐specific DEGs.
In cell composition analysis, DEGs were also found to be highly enriched in the cytosol. We identified a
total of 68 types of drugs or molecular compounds that are promising to reverse OA-related DEGs.
Honeycomb and cinnamon oil have the possibility of treating OA.

Conclusion:

Our findings suggest new biomarkers that can be used to diagnose OA. Furthermore, we
tried to find drugs and traditional Chinese medicine that may improve the progress of OA. This research
may improve the identification and treatment of these uncontrollable chronic diseases.
The Impact of Bioactive Compounds Derived from Marine Fish on Cancer
Authors: Mirunalini S. , Maruthanila V.L.
Published: April 2022

Cancer persists as the world's leading cause of mortality, thereby making it a compelling condition to research and potentially develop prevention options. Anticancer therapies such as chemotherapy, surgery and radiation therapy are becoming highly futile and tend to have achieved a clinical deficit, due to massive side effects, toxicities, and limited specificity. Anticancer agents from natural sources, such as aquatic fishes, terrestrial mammals, animal venoms, and amphibians, have mainly been focused on in recent researches. Edible marine fishes contain high contents of fatty acids, vitamins, and proteins, also having bioactive compounds. Fish derivatives are naturally having the potential to target cancer cells while being less hazardous to normal tissues, making them a better choice for cancer prevention and therapy. In this review, we mainly focused on the bioactive compounds identified from marine fishes which have significant biological properties including anticancer effects, also discuss the mechanism of action.
The Impact of the Coronavirus (COVID-19) Infection on the Drug-
Metabolizing Enzymes Cytochrome P450s
Authors: Elfaki Imadeldin
Published: April 2022

Coronaviruses cause disease in humans and animals. In 2019 a novel coronavirus was
first characterized in Wuhan, China causing acute respiratory disease and designating the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or COVID-19. The COVID-19 spread to
all cities of China and in 2020 to the whole world. Patients with COVID-19 may recover without
medical treatment. However, some patients need medical care. The Cytochrome p450s (CYP450s)
are a large superfamily of enzymes that catalyze the metabolism of endogenous substrates and
xenobiotics. CYP450s catalyze the biotransformation of 80% of the drug in clinical use. The
CYP450 is present in liver, lungs, intestine and other tissues. COVID-19 has been reported to decrease
the activity of certain isoforms of CYP450s in an isoform specific manner. Furthermore, the
COVID-19 infection decreases the liver functions including the drug clearance or detoxification
medicated by the CYP450s. The healthcare providers should be aware of this disease-drug interaction
when prescribing drugs for the treatment of COVID-19 and other comorbidities.
Preparation and Characterization of Stattic-Loaded Albumin Nanoparticles
for Antimetastatic Cancer Treatment
Authors: Kwa Yee Chu , Anasamy Theebaa , Foo Yiing Yee , Leo Bey Fen , Chung Ivy , Kiew Lik Voon , Chung Lip Yong
Published: April 2022

Background:

Stattic offers a unique inhibitory effect on the STAT3 signaling pathway, a crucial mechanism in the progression of metastatic cancer. However, the development of Stattic has been impeded by its hydrophobicity and lack of specificity. To overcome these limitations, encapsulation of Stattic with polymeric micelles was previously attempted, which led to a significant increase in the potency of Stattic on breast cancer cell lines. The presence of albumin was believed to contribute to such enhancement, as the protein corona layer formation helps to retain the micellar structure before eventual uptake by the cells. Moreover, a previous study had reported the unique affinity of Stattic towards albumin molecule.

Objective:

This study aimed to explore the integration of Stattic in albumin-based nanoparticles and to assess the in vitro effects.

Method:

Albumin/Stattic nanoparticles were prepared by crosslinking with glutaraldehyde.

Results:

The yielded nanoparticles were 150.0 ± 6.6 nm in size, with ~53% entrapment efficiency. The cumulative release of Stattic in a tumoric acidic environment (pH 5.3; 59%) was 2.6-fold more than neutral environment (pH 7.4; 23%). In blood plasma, 7% cumulative release was observed. The mathematical modeling of the release kinetics revealed that the albumin/Stattic nanoparticles in phosphate buffer saline and plasma followed Korsmeyer-Peppas and Higuchi model, respectively. Among the two cell lines tested, metastatic MDA-MB-231 cells were more sensitive to entrapment of Stattic with albumin nanoparticles, as the IC50 value decreased by 2.5-fold compared to free Stattic.

Conclusion:

This study reports the formation of low immunogenic and cost-efficient albumin nanoparticles to improve the delivery of Stattic.
DoE-based Optimization of Oral In-situ Gel containing Dandelion Leaf
Extract
Authors: Patel Dinal V. , Dholakia Mansi , Chauhan Harshida , Suhagia Bhanubhai N.
Published: April 2022

Aim:

The present study developed an oral in-situ gel containing the leaf extract of Tarax-acum officinale (T.O.) using an experimental design.

Background:

Peptic ulcer disease was an epidemic in the 19th and early 20th centuries. The applica-tion of herbal drugs for peptic diseases is an attractive area for research and implementation as compared to the allopathic system in the recent era. From the number of plants, the antioxidant effect of an aqueous extract of Taraxacum officinale, which is the dandelion leaf, was proven by an animal study in previous literature. However, most of the marketed preparations consist of root ex-tract primarily used for the detoxification of the liver in comparison to the leaf extract having a non-specific application. Hence, the aqueous extract of dandelion leaf was taken as the active ingredient in the formulation. Over the past 30 years, greater attention has been given to the development of controlled and sustained drug delivery systems. The development of in situ gel systems has received considerable attention over the past few years due to the number of advantages.

Objective:

By considering the merits of herbal ingredients with drug delivery technology, herbal in-situ gel was developed using statistical analysis.

Methods:

Herbal in-situ oral gel was developed using a factorial design. The concentration of sodi-um alginate, xanthan gum, and HPMC K15 M was taken as the factors, and viscosity and drug re-lease (total phenol content) in 10 h were selected as the responses. By evaluating the designed batches, the optimized batch was chosen as the promising formulation for curing the peptic ulcer.

Results:

The batch consisting of 1.711% w/v sodium alginate, 0.727% w/v xanthan gum, and 0.869% w/v HPMC K15M was selected as the optimized batch, as per the software, and the viscosi-ty and % drug release in 10 h were found to be 299.5 cps and 70.2%, respectively. Other evaluation parameters such as gelling capacity, floating parameters, and stability were also found to be good for the designed batches.

Conclutions:

The improved in-situ gel was found to be effective for extending the floating of the drug incorporated into the formulation as well as the residence time in the stomach for sustained drug release.
Efficacy of Propyl Selenoethers Against Peroxyl Radical Induced Protein
Damage: Effect of Functional Group Substitution
Authors: Gandhi Vishwa V. , Das Ram P. , Singh Beena G. , Kunwar Amit
Published: April 2022

Background:

Proteins are the critical bio-molecules for cellular function and are also considered
to be highly susceptible to reactive oxygen species (ROS)-induced oxidative damages.

Methods:

The present study aimed to evaluate some simple water-soluble aliphatic organoselenium
compounds bearing different functional groups but of similar carbon chain (propyl) length for a protective
effect against 2,2’-azobis-(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative
damage using mitochondria as an in vitro model.

Results:

The results indicated that APPH (20 mM) treatment of mitochondrial fraction induced protein
carbonylation, leading to inactivation of redox enzymes and electron transport chain (ETC) and, ultimately
the mitochondrial dysfunction. On the other hand, treatment with 0.5 mM of monoselenobutyric
acid (SeBA) and monoselenopropyl alcohol (SePOH) significantly prevented APPH-induced protein
carbonylation in mitochondrial fraction and restored activities of mitochondrial proteins. On the
contrary, monoselenopropyl amine (SePAm) treatment at identical concentrations did not show significant
protection to mitochondrial activity from AAPH-induced oxidative damages. The above results
concur with the reported peroxyl radical scavenging activities of the above molecules.

Conclusion:

In conclusion, SeBA and SePOH are potential candidate molecules to protect proteins
from oxidative damage and, therefore, can be useful for managing oxidative stress in cellular models.
Conductivity Study on Proton-Conducting Nanocomposite Plasticized Polymer Electrolytes: A Review
Authors: Kumar Rajiv , Sharma Shuchi , Pathak Dinesh , Dhiman Naresh , Prashar Kamlesh Kumar , Kahol Manoj , Arora Narinder , Sharma Viney
Published: April 2022

This paper reviews proton-conducting polymer electrolytes comprising different polymers, salts, and acids. The ionic conductivity of plasticized polymer electrolytes has been found to increase with the addition of plasticizers due to the dissociation of ion aggregates or undissociated salt/acid present in the electrolytes, i.e., σ (plasticized polymer electrolytes) > σ (unplasticized polymer electrolytes). Proton-conducting nonaqueous nanocomposite plasticized polymer electrolytes containing poly(vinylidene fluoride-co-hexafluoropropylene) (PVdF-HFP), polymethylmethacrylate (PMMA), polyethylene oxide (PEO) polymers; different ammonium salts and acids as proton conductors; ethylene carbonate (EC), propylene carbonate (PC), dimethylformamide (DMF), dimethylacetamide (DMA), dimethyl carbonate (DMC), diethyl carbonate (DEC) as plasticizers; fumed silica and alumina as nano-fillers have been discussed in details. Conductivity studies (effect of salt/acid, effect of plasticizers, effect of nano-fillers, and effect of temperature), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetry/thermal gravimetric analysis (DSC/TGA) studies for these electrolytes have been discussed and reported in the paper. Nanocomposite plasticized polymer electrolytes showed high ionic conductivity (in the order of 10-1 to 10-2 S/cm) at room temperature along with good thermal and mechanical stability due to the simultaneous addition of both plasticizers and nano-fillers. These nanocomposite polymer electrolytes are the best candidates for use in various electrochemical devices like solid-state batteries, fuel cells, supercapacitors, sensors, separators, and other electrochromic devices.
EFEKTIVITAS JAMINAN PENDIDIKAN DAERAH (JPD) DALAM MENURUNKAN ANGKA PUTUS SEKOLAH DI KOTA YOGYAKARTA
Authors: Kusuma Dwi Widiawati Wijaya
Published: April 2022

This research aims to determine the effectiveness of the Regional Education Grant in reducing dropout rates in the City of Yogyakarta. The author explored the effectiveness of the Regional Education Grant on its role in reducing dropout rates, so the author explores Regional Education Grant rights in their role in reducing dropout rates for the last 5 years (2015-2019). This research adopted a descriptive quantitative research, this research described the situation that occurred, without testing the hypothesis with secondary data analysis methods which were complemented by the interview method. The population in this research were dropout rates in the city of Yogyakarta during the last 5 years. The data analyses used the regression coefficient analysis and the determination coefficient analysis. The result of this research is that the education security program can not be said to be effective, especially in reducing the dropout rates. The tendency causes were the problems of achievement program that were not maximized yet, especially due to the external factors such as the achievement of Regional Education Grant goals unsupport by public. For example, there was a missunderstanding information, which lead to the highest reason for dropping out rates in the City of Yogyakarta. It was actually triggered by a lack of motivation to learn so that the students were reluctant to go to school, with a percentage of 29.70%.
KULTUR SEKOLAH DALAM MEWUJUDKAN PENDIDIKAN BERBASIS KEUNGGULAN LOKAL BATIK DI SMA NEGERI 1 SOKARAJA
Authors: Abiyoga Berlian Bima
Published: April 2022

This research aimed to describe school culture in the realization of Batik local content based education in 1 Sokaraja State Senior High School. The focuses of this study were deep explaination of school culture which was Batik local content based education and how to realize it. This research used descriptive qualitative approach. Data were collected using observation, interview, and documentation. Data analysis was done using interactive analysis model by Miles and Huberman namely data condensation, data presentation, and drawing conclusion. The data were validated using technique and source triangulations. The results of this study indicated that physically and behaviorally 1 Sokaraja State Senior High School has supported the school culture of Batik local content based education. Three basic layers of school culture were assumptions, values, and artifacts. The assumptions of the founders of Batik local content based education at 1 Sokaraja State Senior High School who strongly wanted to elevate the local culture of Banyumas Batik underlie the formation of  Batik local content based education. The values that applied were the value of cleanliness, the value of discipline, the culture of courtesy, the value of achievement, and the cultivation of local values. Then, the artifacts were in the forms of supporting facilities, efforts, and programs that support the Batik local content based education.Keywords: School Culture, Local Content based Education, Batik
PENANAMAN NILAI DALAM PENGUATAN PENDIDIKAN KARAKTER DI SMP NEGERI 8 YOGYAKARTA
Authors: Pratiwi Eka
Published: April 2022

The purpose of this research is to describe the inculcating value in strengthening character education in SMP Negeri 8 Yogyakarta. This research is a descriptive qualitative research. The subjects in this research were the principal, educators, students and parents/ guardians of students. Data collection techniques were using observation, interviews, and documentation. The data analysis technique used the Milles and Huberman model, namely using the data condensation step, presenting the data, and drawing conclusions. Test the validity of the data in this research using triangulation. The research results showed that: (1) Guidelines in inculcating values with the 2013 curriculum, syllabus and document books (rules of conduct). (2) The process of inculcating character values at SMP Negeri 8 Yogyakarta uses three ways, namely by providing understanding / knowledge, through habits, and through good examples conducted by school principals and educators. (3) The values implanted are religious, nationalist, independent, mutual assistance and integrity values. (4) The supporting factors are the culture of the school, facilities and infrastructure, good relationship with the school community. The inhibiting factor is the understanding of different school members about character education, so it takes patience and hard work from the school in an effort to equalize perceptions so that the implementation of character education is as expected, educators who have not maximally provided understanding, and low parental understanding.   Keywords: Inculcating Value, PPK
TREN ANGKA PARTISIPASI PENDIDIKAN MENENGAH DAN PERENCANAAN KEBIJAKAN PARTISIPASI PENDIDIKAN DI PROVINSI JAWA TENGAH
Authors: Fiana Rob
Published: April 2022

Tujuan penelitian ini adalah: 1) mengetahui prediksi ketercapaian APK/APM Pendidikan Menengah di Provinsi Jawa Tengah, 2) mengetahui prediksi ketercapaian APK/APM Pendidikan Menengah kabupaten/kota di Provinsi Jawa Tengah, 3) mengidentifikasi kebijakan dan program yang diberlakukan oleh Pemerintah Jawa Tengah dalam meningkatkan angka partisipasi pendidikan menengah, dan 4) menganalisa kebijakan berdasarkan hasil prediksi APK/APM untuk meningkatkan angka partisipasi pendidikan menengah. Penelitian ini merupakan penelitian campuran. Analisis data kuantitatif menggunakan tren model kuadrat terkecil  dan data kualititatif menggunakan model interaktif. Hasil penelitian menunjukkan bahwa: 1) APK Pendidikan Menengah di Jawa Tengah diprediksi dapat mencapai target PMU 97% pada tahun 2025 dan diprediksi mencapai 97,957%, sedangkan APM hingga tahun 2030 belum bisa mencapai 100% dan diprediksi mencapai 84,624%. 2) Berdasarkan hasil perhitungan Analisis Tren APK/APM Pendidikan Menengah Kabupaten Temanggung, Kabupaten Wonosobo, Kabupaten Blora, dan Kabupaten Jepara menunjukkan peningkatan, sedangkan Kota Surakarta dan Kota Semarang mengalami penurunan. 3) Pemerintah Jateng membagi kebijakan dalam aspek operasional kelembagaan, personal siswa, peningkatan akses, dan mutu dalam meningkatkan partisipasi Pendidikan Menengah. 4) Dinas Pendidikan dan Kebudayaan Provinsi Jawa Tengah menindaklanjuti hasil tren dengan cara mempertahankan dan meningkatkan partisipasi pendidikan menengah.Kata kunci: tren, angka partisipasi, pendidikan menengah, rencana kebijakan.
GENDER EQUALITY IMPACT ANALYSIS ON ACADEMIC OF SINGLE PARENTS CHILREN
Authors: Pratiwi Alifah Indah
Published: April 2022

This study aims to describe the application of gender equality in single parent families in the Spinmotion Yogyakarta community and the impact of gender equality on the academic achievement of children in the Spinmotion Yogyakarta community. Descriptive qualitative research, conducted in the Special Region of Yogyakarta. The research subjects are single parents who are members of the Yogyakarta Spinmotion community. Data collection techniques used are observation, interviews, and documentation. The data were analyzed from the informant's point of view with data collection techniques, data condensation, data presentation, and drawing conclusions. The validity of the data was tested by triangulation of sources and increasing persistence. The results of this study: (1) The theoretical meaning of gender is still understood as a gender difference but in the application of gender roles and work it does not refer to gender. The single parent family of the Spinmotion Yogyakarta community has implemented gender equality for their children. (2) Most of the single parent children who are members of the Yogyakarta Spinmotion community have not experienced any changes in learning at school, especially in academic achievement.Keywords: Gender Analysis, Gender Equality, Single Parents,Academic Achievement
KEBIJAKAN SEKOLAH DALAM PENDIDIKAN KARAKTER DENGAN KEGIATAN SENI MUSIK ANGKLUNG DI SD ISLAM TERPADU AL – KHAIRAAT
Authors: Fatmawati Erna
Published: April 2022

AbstrakPenelitian ini bertujuan untuk mendeskripsikan dan mengetahui kebijakan sekolah dalam pendidikan karakter dengan kegiatan seni musik angklung di SD Islam Terpadu Al–Khairaat, yang meliputi 1) kebijakan sekolah dalam pendidikan karakter dengan kegiatan seni musik angklung 2) nilai-nilai karakter yang dihasilkan dalam kegiatan seni musik angklung 3) dampak kebijakan sekolah dalam pendidikan karakter dengan kegiatan seni musik angklung. Penelitian ini merupakan penelitian kualitatif dengan pendekatan studi kasus. Teknik analisis data menggunakan model Miles dan Huberman yaitu dengan langkah reduksi data, penyajian data, verifikasi dan penegasan kesimpulan. Uji keabsahan data pada penelitian ini menggunakan triangulasi teknik dan triangulasi sumber.. Hasil penelitian menunjukkan bahwa. (1) Kebijakan sekolah dalam pendidikan karakter dengan kegiatan seni musik angklung diimplementasikan merujuk empat aspek yaitu: komunikasi, sumberdaya, sikap dan struktur birokrasi, (2) Nilai – nilai karakter yang dihasilkan dalam kegiatan seni musik  angklung ada lima nilai yaitu disiplin, bersahabat, tanggungjawab, peduli sosial, dan cinta tanah air (3) Dampak kebijakan sekolah dalam pendidikan karakter dengan kegiatan seni musik angklung yaitu berdampak pada perubahan perilaku positif pada siswa. Kata kunci: kebijakan sekolah, pendidikan karakter, seni musik, dan angklung AbstractThis research aims to describe and understand the school's policy in character education with angklung music art in the SD Islam Terpadu Al – Khairaat, which includes 1) school policies in character education with art activities angklung music 2) character values are produced in the activity of angklung music art 3) The impact of school policy in character education with angklung music art activities. This research is a qualitative study with a case study approach. Data analysis techniques using the Miles and Huberman models are data reduction steps, data presentation, verification and conclusion confirmation. Test the legality of data on this study using triangulation techniques and triangulation resources. The results showed that. (1) The policy of school in character education with the activities of Angklung music is implemented to refer to four aspects namely: communication, resources, attitudes and bureaucracy structure, (2) value-the value of the character produced in the art of music activities  angklung There are five values that are discipline, friendly, responsibility, social care, and love of Homeland (3) Impact of school policy in character education with the activities of Angklung music art that affects the change of positive behaviour in students.Keywords: school policy, character education, music art, and angklung
Design of a Vaccine Passport Validation System Using Blockchain-based Architecture: Development Study
Authors: Lee Hsiu An , Wu Wei-Chen , Kung Hsin-Hua , Udayasankaran Jai Ganesh , Wei Yu-Chih , Kijsanayotin Boonchai , Marcelo Alvin B , Hsu Chien-Yeh
Published: April 2022

Background

COVID-19 is an ongoing global pandemic caused by SARS-CoV-2. As of June 2021, 5 emergency vaccines were available for COVID-19 prevention, and with the improvement of vaccination rates and the resumption of activities in each country, verification of vaccination has become an important issue. Currently, in most areas, vaccination and reverse transcription polymerase chain reaction (RT-PCR) test results are certified and validated on paper. This leads to the problem of counterfeit documents. Therefore, a global vaccination record is needed.

Objective

The main objective of this study is to design a vaccine passport (VP) validation system based on a general blockchain architecture for international use in a simulated environment. With decentralized characteristics, the system is expected to have the advantages of low cost, high interoperability, effectiveness, security, and verifiability through blockchain architecture.

Methods

The blockchain decentralized mechanism was used to build an open and anticounterfeiting information platform for VPs. The contents of a vaccination card are recorded according to international Fast Healthcare Interoperability Resource (FHIR) standards, and blockchain smart contracts (SCs) are used for authorization and authentication to achieve hierarchical management of various international hospitals and people receiving injections. The blockchain stores an encrypted vaccination path managed by the user who manages the private key. The blockchain uses the proof-of-authority (PoA) public chain and can access all information through the specified chain. This will achieve the goal of keeping development costs low and streamlining vaccine transit management so that countries in different economies can use them.

Results

The openness of the blockchain helps to create transparency and data accuracy. This blockchain architecture contains a total of 3 entities. All approvals are published on Open Ledger. Smart certificates enable authorization and authentication, and encryption and decryption mechanisms guarantee data protection. This proof of concept demonstrates the design of blockchain architecture, which can achieve accurate global VP verification at an affordable price. In this study, an actual VP case was established and demonstrated. An open blockchain, an individually approved certification mechanism, and an international standard vaccination record were introduced.

Conclusions

Blockchain architecture can be used to build a viable international VP authentication process with the advantages of low cost, high interoperability, effectiveness, security, and verifiability.
Reforming the Tourism Promotion Board for an Effective Tourism Promotion in Indonesia: A Legal Perspective
Authors: Santosa Anak Agung Gede Duwira Hadi , Utami Putu Devi Yustitia , Wijaya I Made Marta
Published: April 2022

The Indonesia/Regional Tourism Promotion Board (or I/RTPB) is an agency having duties to assist the development of the tourism sector. Since its establishment, it has not been able to play an optimal role in performing its duties and responsibilities. The purpose of this study is to find out and understand the institutional arrangements for the I/RTPB in the current legislation and to find out and formulate the ideal form of the I/RTPB in accelerating its functions especially for the recovery of the tourism sector in the post-pandemic context. This article uses a doctrinal research method with a statutory approach. The study shows the problem of the provisions on the I/RTPB in the Tourism Law in Chapter X from Article 36 to Article 49. To properly function for the economic recovery after the pandemic, there is a need to restructure the I/RTPB as an independent body with a mandate in the field of tourism promotion.
Indigenous Peoples in Regional Institutions: A Comparative Perspective between ASEAN and the Arctic Council
Authors: Mahendra Muhammad Dwiki
Published: April 2022

The study of Indigenous People is a vast subject and it is continuously growing. Indigenous Peoples often lack formal recognition over their lands, rights, and at worst, their identities hence they are often undermined by the government and international law. Such things were possible since the recognition of Indigenous Peoples is varied and depends on each national or regional perspective. Within Southeast Asia’s regional organization, the Association of Southeast Asian Nations (ASEAN), no reference to the Indigenous Peoples was made on its founding document. This paper focuses on the issue of Indigenous Peoples by comparing the position of Indigenous Peoples within the framework of ASEAN to Arctic Council. By qualitatively analyzing relevant references on ASEAN, Arctic Council, and Indigenous Peoples, this article aims to understand the stark differences of how ASEAN and Arctic Council recognize the Indigenous Peoples within each region. Such understanding is necessary to drives ASEAN and its member states to accommodate broader rights to Indigenous Peoples.
Sijori-GT Economic Cooperation for Three Decades: Examining Malaysia’s and Singapore’s FDI Commitments to Riau Islands
Authors: Nazaruddin La Ode , Aulia Qisthina
Published: April 2022

The Singapore-Johor-Riau Growth Triangle (Sijori-GT) was initiated by the government of Singapore, Malaysia, and Indonesia in 1989. It took the advantages of complementarities among the involved regions. The peripheral regions were expected to reap benefits and gain spillovers from the extended metropolitan region of Singapore.  In the age of 30 years of the growth triangle, many scholars found great progress and challenges of the subregional economic cooperation such as unbalanced development and allegedly weak commitment of the participating countries in Riau Islands. This research has the aim to investigate the tenable commitments of Singapore’s and Malaysia’s Foreign Direct Investment (FDI) in Riau Islands. Using statistical data from Indonesia’s Ministry of Investment from 1990 to 2020, this study compared FDI in Riau Islands by origin, and Singapore's and Malaysia's FDI by sector and subsector. The data was analyzed using the independent sample t-test for two-variable comparison and analysis of variance (post-hoc test) for multiple-variable comparison. Finally, this study found that: firstly, investment of Singapore was larger than that of Malaysia in Riau Islands; secondly, Singapore specialized its investment in manufacturing sector having better comparative advantage while Malaysia specialized its investment in non-manufacturing sector with potential assumed capabilities in halal-related sectors. The implication of this research is the importance of provision of competitive policies on industrial land estate prices to attract more investment in Riau Islands and to improve halal-related services to take advantage of domestic halal market and cross-border halal trade.
Políticas e implementación de estrategias para la educación en línea. Reseña del 12º Coloquio Nacional de Educación Media Superior a Distancia
Authors: Rivera Martínez Lucila , Hernández Pérez Romy
Published: April 2022

Desde hace 12 años, la Red de Bachilleratos Universitarios Públicos a Distancia de México organiza un Coloquio Nacional con la finalidad de fortalecer y promover un espacio de diálogo e intercambio de experiencias entre los agentes que intervienen en la educación media superior a distancia. En este documento se presenta una reseña muy general sobre lo abordado en dicho Coloquio.
La evolución del primer bachillerato con un currículum de recursos abiertos
Authors: Tonks DeLaina
Published: April 2022

Se presenta el origen y evolución de Mountain Heights Academy, en Utah, Estados Unidos, que constituye el primer bachillerato en el mundo basado en un currículum de recursos abiertos y cuenta con un educación individualizada y centrada en el estudiante. Desde el inicio se definió que el desarrollo de los cursos se basaría en recursos educativos abiertos. Se establecieron políticas, procedimientos e infraestructura para garantizar la apertura sólida y exitosa de la escuela en 2009. Seis años después se hizo una revisión y alineamiento de su misión, visión, metas y objetivos que permitió un crecimiento de la matrícula, así como una mayor tasa de egreso, entre otros cambios positivos. El artículo describe detalles importantes de la gestión escolar y del trabajo de los profesores de este bachillerato totalmente en línea.
Programas de extensión en los niveles preescolar a bachillerato y su impacto en tutores pares universitarios
Authors: Diaz Joe , Wagh Aditi , Urrea Claudia , DeLong Kirky
Published: April 2022

Las actividades prácticas, de aprender al hacer, resultan fundamentales para la experiencia educativa de tipo ingenieril tanto a nivel de estudiantes de pregrado como de posgrado. Sin embargo, está bien documentado que esta forma de aprender puede ser, y a menudo es, increíblemente efectiva con los estudiantes más jóvenes. En muchas instituciones, la cultura de brindar servicios de extensión a los estudiantes en los grados preescolar a bachillerato se ha vuelto cada vez más común. Si bien estos varían en cuanto a la práctica, las disciplinas y la forma, muchas ofertas y programas han sido diseñados por profesores, estudiantes universitarios y personal y, a menudo, comparten puntos en común al ser atendidos por estudiantes universitarios, lo que les permite no solo compartir el conocimiento adquirido en el aula, sino también desarrollar habilidades de tutoría, al aportar orientación sobre carreras y decisiones de vida para audiencias más jóvenes. Estas oportunidades tienen un claro beneficio para los niños que participan. Sin embargo, pueden ser menos evidentes los impactos que la tutoría tiene en los estudiantes universitarios que eligen participar y, como resultado, aprenden sobre las prácticas de orientación. Considerar los caminos que se pueden tomar para expandir los esfuerzos existentes y establecer conexiones más sólidas con mentores universitarios que trabajan con poblaciones de preescolar a bachillerato puede, en última instancia, aumentar el impacto en los estudiantes de muchas edades y brindar oportunidades de crecimiento para los estudiantes universitarios que participan en estos programas.
Entrevista al doctor Juan Pablo Arroyo Ortiz, subsecretario de Educación Media Superior de la Secretaría de Educación Pública (SEP) de México
Authors: Vadillo Guadalupe
Published: April 2022

En esta entrevista, el Subsecretario de Educación Media Superior de México presentó algunos elementos fundamentales del nuevo Marco Curricular Común para dicho nivel educativo. Subrayó la importancia de contar con transversalidad de los contenidos, incluir el componente socio-emocional, trabajar las ciencias sociales como un conjunto y promover la cultura digital. Comentó, también, la posibilidad de tener movilidad entre modalidades en el caso de Prepa en Línea de la SEP.
La educación virtual y a distancia como estrategia para garantizar la cobertura en Educación Media Superior. Entrevista al doctor Marcial Rodríguez Saldaña, secretario de Educación del estado de Guerrero
Authors: Bonilla Gómez Felicidad del Socorro
Published: April 2022

En una charla abierta y amena, el secretario de Educación de Guerrero, Dr. Marcial Rodríguez Saldaña, expuso las estrategias que la dependencia a su cargo busca implementar para mejorar los indicadores educativos en la entidad, particularmente la cobertura en educación media superior, que representa el eslabón más débil del sistema educativo, tanto a nivel local como nacional.
Arte y poder, las armas de Mariano Riva Palacio, un mecenas nacionalista del siglo XIX mexicano
Authors: Pérez Cárdenas Irma Yolanda
Published: April 2022

Mariano Riva Palacio fue un importante mecenas del arte en la segunda mitad del siglo XIX mexicano. Desde el poder patrocinó monumentos públicos de los héroes de la independencia con una retórica política que promovía un sentimiento nacionalista, el cual respondía a las necesidades de consolidación y legitimación del gobierno de ese momento: la república restaurada. En este escrito sólo citaré algunas de sus obras más importantes, sin entrar en el análisis iconográfico o procesual. Sólo pretendo, a través de documentos, especialmente de su archivo personal, mostrar su constante actividad como patrono, sus intenciones políticas y cómo se comenzaron a construir las imágenes visuales públicas de los próceres del nuevo panteón cívico.