bluuebunny/crossref_metadata_2025 huggingface dataset:
ФАРМАКОЕКОНОМІЧНІ АСПЕКТИ ПОТЕНЦІЙНОГО СПОЖИВАННЯ ЛІКАРСЬКИХ КОСМЕТИЧНИХ ЗАСОБІВ ТА КОСМЕТИЧНИХ ЗАСОБІВ, ДО СКЛАДУ ЯКИХ ВХОДИТЬ САЛІЦИЛОВА КИСЛОТА
Authors: Кілєєва Ольга Павлівна , Бушуєва Інна Володимирівна
Published: February 2024

Лікування і профілактика акне повинні бути індивідуалізованими і враховувати форму, локалізацію, поширеність та наявність запальних елементів. Найбільш ефективним є консервативне лікування у комплексі з лікарськими косметичними засобами (ЛКЗ) і косметичними засобами (КЗ) [1; 2]. Перевага комплексної терапії під час застосування лікарських косметичних засобів та косметичних засобів полягає у тому, що креми та гелі швидко вбираються, насичують клітини шкіри кератином, нормалізують аномальний ріст клітин, знімають почервоніння, свербіж і печіння, допомагають домогтися тривалої ремісії захворювання. Для догляду за шкірою варто використовувати легкі, нежирні пом’якшувальні та зволожуючі засоби без запаху, без додавання барвників, консервантів та емульгаторів. Згідно з науковими працями, прослідковується закономірність, що чим меншу кількість інгредієнтів містять лікарські косметичні засоби і косметичні засоби, тим меншою буде вірогідність виникнення реакцій підвищеної чутливості, алергії та погіршення перебігу вугрової хвороби [3; 4]. Проведено дослідження щодо стану і сучасних тенденцій розвитку фармацевтичного ринку ЛКЗ і КЗ для вирішення дерматологічних патологій (а саме акне), що дало змогу визначити значний потенціал його розвитку. Визначено показники стійкості асортименту препаратів цієї групи, їхньої конкуренто- та платоспроможності для подальшого вивчення доступності цього переліку препаратів і можливості задоволення потреб населення у лікуванні названої патології [5]. Установлено, що асортимент лікарських косметичних засобів та косметичних засобів, що містять саліцилову кислоту, для профілактики та лікування акне є стійким. Досліджено уніфіковані клінічні протоколи первинної, вторинної (спеціалізованої), третинної (високоспеціалізованої) медичної допомоги (УКПМД) щодо надання фармацевтичної допомоги при акне [6]. Практичне значення дослідження полягає у подальшому вдосконаленні фармацевтичної допомоги у загальній системі забезпечення медичними послугами у разі лікування та профілактики звичайних вугрів.
РОЛЬ КАТЕСТАТИНУ ТА РЕЛАКСИНУ-2 У ДІАГНОСТИЦІ ГІПЕРТОНІЧНОЇ ХВОРОБИ ТА ЦУКРОВОГО ДІАБЕТУ 2 ТИПУ: РЕЗУЛЬТАТИ СПОСТЕРЕЖЕННЯ УПРОДОВЖ 12 МІСЯЦІВ
Authors: Панкова Олена Андріївна , Корж Олексій Миколайович
Published: February 2024

Мета – дослідити частоту розвитку несприятливих серцево-судинних подій у пацієнтів з гіпертонічною хворобою (ГХ) залежно від рівнів катестатину (КТС) та релаксину-2 (РЛН-2) у плазмі крові упродовж 12 місяців спостереження. Матеріали та методи. До дослідження залучено 136 учасників дослідження: 106 пацієнтів з ГХ та 30 практично здорових добровольців. Залежно від наявності супутнього цукрового діабету 2 типу (ЦД2т) пацієнти з ГХ були розподілені на 2 групи: 1 група – 55 пацієнтів з ГХ та ЦД2т, 2 група – 51 пацієнт з ГХ без супутнього ЦД2т. Усім учасникам дослідження проведено комплексне клінічне обстеження, лабораторні та інструментальні дослідження на візиті скринінгу з подальшим спостереженням упродовж 12 місяців щодо розвитку кінцевих точок: смерть із серцево-судинних причин, ішемічний інсульт, гострий інфаркт міокарду, гостра серцева недостатність. Концентрації КТС та РЛН-2 у плазмі крові визначено за допомогою імуноферментного аналізу. Статистичний аналіз даних виконано за допомогою статистичної програми SPSS 25.0. Результати. У пацієнтів з ГХ зареєстровані випадки серйозних серцево-судинних ускладнень, тоді як у учасників контрольної групи не виявлено розвитку кінцевих точок. Спостерігалась дещо вища частота розвитку кінцевих точок у пацієнтів з ГХ та ЦД2т, проте відмінність була статистично незначимою (p>0,05). У пацієнтів з концентраціями КТС<5,44 нг/мл встановлена достовірно вища частота розвитку кінцевих точок (p=0,01), тоді як не виявлено відмінностей щодо розвитку серцево-судинних ускладнень залежно від рівнів РЛН-2 (p=0,37). Висновки. ГХ приводить до підвищення ризику смертності із серцево-судинних причин та нелетальних серйозних серцево-судинних ускладнень. Встановлений підвищений ризик розвитку несприятливих серцево-судинних подій у пацієнтів з ГХ з нижчими концентраціями КТС свідчить про зв’язок рівнів КТС з характером перебігу захворювання та його потенціал у діагностиці ГХ.
Pengaruh Komunikasi dan Kerjasama Tim Terhadap Produktivitas Kerja (Studi pada Puskesmas Karangpucung 2 Kabupaten Cilacap)
Authors: Makmur Hidayat Adi , Budianto Apri , Herman Ferey
Published: February 2024

Penelitian  ini dilatarbelakangi oleh adanya beberapa masalah yang berhasil diidentifikasi sebagai berikut: Produktivitas kerja pegawai Puskesmas Karangpucung II Kabupaten Cilacap  dilihat dari aspek efektivitas masih belum efektif. Produktivitas kerja pegawai Puskesmas Karangpucung II Kabupaten Cilacap  dilihat  dari aspek ketepatan waktu pegawai dalam menyelesaikan pekerjaan masih kurang tepat. Produktivitas kerja pegawai Puskesmas Karangpucung II Kabupaten Cilacap  dilihat dari aspek capaian hasil kerja pegawai yang sesuai dengan target yang telah ditentukan masih kurang. Produktivitas kerja pegawai Puskesmas Karangpucung II Kabupaten Cilacap  dilihat dari efesiensi biaya yang di gunakan masih belum optimal. Komunikasi antara pegawai  dengan pegawai masih belum optimal. Komunikasi antara pegawai dengan atasan dapat di katakan masih belum optimal. Masih ada beberapa pegawai yang sulit untuk di ajak kerjasama dalam menyelesaikan pekerjaan. Kerjasama yang terdiri dari banyak orang menuntut adanya kesamaan ide dan gagasan yang sulit untuk di wujudkan Dengan demikian maka tujuan penelitian ini adalah untuk mengetahui dan mendeskripsikan pengaruh komunikasi  terhadap  produktivits kerja pada Puskesmas Karangpucung 2 Kabupaten Cilacap. Untuk mengetahui dan mendeskripsikan pengaruh kerjasama tim terhadap  produktivits kerja pada Puskesmas Karangpucung 2 Kabupaten Cilacap?. Untuk mengetahui dan mendeskripsikan pengaruh komunikasi  dan kerjasama tim terhadap  produktivits kerja pada Puskesmas Karangpucung 2 Kabupaten Cilacap.Metode yang digunakan adalah deskriptif survey. Hasil penelitian menunjukkan bahwa Komunikasi  cenderung baik dan produktivitas kerja pegawai  cenderung baik, sehingga komunikasi  berpengaruh positif dan signifikan terhadap produktivitas kerja pegawai. Artinya, semakin baik komunikasi, maka akan semakin baik produktivitas kerja pegawai. Kerjasama tim  cenderung baik dan produktivitas kerja pegawai  cenderung baik, sehingga Kerjasama tim  berpengaruh positif dan signifikan terhadap produktivitas kerja pegawai. Artinya, semakin baik Kerjasama tim, maka akan semakin baik produktivitas kerja pegawai. Komunikasi dan kerjasama tim  secara serentak berpengaruh terhadap produktivitas kerja pegawai . Pengaruh komunikasi  dan kerjasama terhadap produktivitas kerja pegawai  termasuk kategori tinggi.
Pengaruh Motivasi, Komitmen Pegawai Dan Kompetensi Terhadap Kinerja Pegawai (Studi pada Dinas Pengendalian Penduduk Keluarga Berencana Pemberdayaan Perempuan dan Perlindungan Anak Kabupaten Ciamis)
Authors: Herawati Sri , Budianto Apri , Herman Ferey
Published: February 2024

Penelitian ini melakukan sebuah riset penelitian dalam menilai pengaruh motivasi, komitmen dan kompetensi terhadap kinerja pegawai. Rumusan masalah yang diajukan dalam penelitian ini yaitu sebagai berikut:  1) Bagaimana pengaruh Motivasi tehadap kinerja pegawai pada DP2KBP3A Kabupaten Ciamis?; 2) Bagaimana pengaruh komitmen pegawai tehadap kinerja pegawai pada DP2KBP3A Kabupaten Ciamis; 3) Bagaimana pengaruh kompetensi terhadap kinerja pegawai pada DP2KBP3A Kabupaten Ciamis. 4) Bagaimana pengaruh Motivasi, komitmen pegawai dan kompetensi terhadap kinerja pegawai pada DP2KBP3A Kabupaten Ciamis? Metode penelitian yang digunakan adalah metode kuantitatif deskriptif dengan metode penyebaran kusioner atau angket. Teknik pengumpulan data dalam penelitian ini adalah studi pustaka dan studi lapangan. Sedangkan teknis analisis data yang digunakan penulis dalam penelitian ini yaitu dengan penyebaran kusioner Dari penelitian bahwa dapat diperoleh: 1) Hasil dari penelitian di DP2KBP3A Kabupaten Ciamis berpengaruh positif terhadap kinerja petugas dan berpengaruh signifikan, artinya apabila motivasi, komitmen dan kompetensi yang sangat tinggi maka akan berpengaruh terhadap kinerja petugas. Jadi motivasi, komitmen dan kompetensi adalah factor utama dalam meningkatkan kinerja petugas pada Dinas Pengendalian Penduduk Keluarga Berencana Pemberdayaan Perempuan dan Perlindungan Anak Kabupaten Ciamis akan meningkat pula.
The Effect of Customer Satisfaction, E-Word of Mouth, and Initial Trust on Livin's Mobile Banking Adoption Interest
Authors: Komara Edi , Tri Utami Dina
Published: February 2024

This research aims to investigate the impact of positive Electronic Word of Mouth (eWOM) on the adoption of Mobile Banking. In this study, it was found that Argument Quality, Valence, and Customer Satisfaction have a positive influence on Initial Trust, which in turn affects the intention to adopt Mobile Banking. This study uses a descriptive research design approach with empirical data collected through an online survey of PT Bank X's customer respondents in East Jakarta. The collected data was subsequently analyzed using the Partial Least Square (PLS) analysis method with the aid of smartPLS 4.0 software. The results of this study, there is no positive impact from Consistency and Volume Review on Initial Trust. The findings of this study provide recommendations to banks to leverage positive eWOM to encourage customers to adopt Mobile Banking. These findings emphasize the importance of Customer Satisfaction in enhancing Initial Trust, which contributes to the usage of Mobile Banking applications and Customer Satisfaction
Image Enhancement for the Improved Extraction of Local Image Features Using Image Offsets
Authors: Psaila Jonathan
Published: February 2024

In this thesis, an algorithm for improved feature extraction is presented using enhancement offsets that are created dynamically with adaptive parameter selection. The algorithm operates by analyzing an input image and building image offsets to improve colour contrast, non-uniform illumination and lack of detail which allows for additional keypoints to be detected by numerous different detectors. Comparative keypoint detection testing on the enhanced images is conducted to test if more keypoints can be extracted using the method. Keypoint strength experiments are also conducted as well as quality assessment experiments to test the validity of the proposed algorithm as an image enhancement method. Image matching experiments though SIFT and SURF are also conducted. It is quantitatively shown that the proposed algorithm results in visual improvements, as well as in additional, stronger keypoints being detected in all images irrespective of the detector used. Matching experiments are conducted using the Webcam, Heinly, and Oxford/EF datasets wherein the proposed algorithm consistently outputs more correct matches and achieves higher or similar matching accuracy compared with related enhancement algorithms using SIFT and SURF.
Successive Approximation Analog-to-Digital Converters In Time-Mode Signal Processing
Authors: Siddiqui Rashed
Published: February 2024

The need for Time-Mode Signal processing is discussed. A background for Analog-To-Digital Converters is reviewed. Different approaches and key building blocks of Time Mode Analog-to-Digital conversion are discussed. A new approach for Successive Approximation Register (SAR) Time-to-Digital Converter (TDC) which is called Double Edge SAR TDC is presente. A 4-bit implementation of the Double Edge SAR TDC is done in 65nm TSMC technology and compared against a standard implementation. The new 4-bit design is the Double Edge SAR TDC is able to achieve an ENOB of 3.91 bits and is able to achieve 24% power saving over the classic architecture. The Double Edge SAR TDC is then integrated in a 7-bit two-step Time Domain ADC which was able to achieve an ENOB of 5.312 bits and FOM of 173.5 fJ/conv.
AI Empowered Computing Resource Allocation in Vehicular Ad-Hoc Networks
Authors: Saleh Ayat Hama
Published: February 2024

The vehicular ad hoc network (VANET) has emerged as a heterogeneous network with no fixed infrastructure. In VANET, vehicles are the mobile nodes that communicate with one another and with the infrastructure. One of the major challenges in VANET is to allocate resources efficiently due to environmental characteristics such as highly mobile vehicles, latency-sensitive and short connection times. The conventional resource management mechanisms are not very effective in such an environment. The data-driven Artificial Intelligence (AI) based techniques are a very efficient alternative to traditional statistical techniques. This project proposes an AI-empowered task offloading and computing resource allocation model which can dynamically organize the computing resources in VANET. The model is divided into two layers. First, the task offloading layer, where the Random Forest (RF) algorithm is used to determine whether the vehicle’s computing tasks should be offloaded to the cloud computing (CC) server or mobile edge computing (MEC) server or to be processed locally (in-vehicle computing). Second, the resource allocation layer, where the deep deterministic policy gradient (DDPG) algorithm is used to determine the computing platform again when the task is determined to be offloaded to either MEC servers or the cloud servers. To evaluate the performance of the RF classifier, we applied the model to a real-world driving trajectory dataset then compared the results with a different set of machine learning algorithms namely, K-nearest neighbour (KNN), Multilayer Perceptron (MLP) and Support Vector Machine (SVM). The results show the RF model outperformed other models in classification accuracy score of 99.83% for task offloading decision, where the KNN, MLP and SVM achieved 98%, 94.81% and 90.94%, respectively. Moreover, the DDPG based resource allocation scheme converges within 150 episodes. Thus, the proposed model can find the optimal offload decision and the computational resource allocation simultaneously and achieves a high delay to quality-of-service (QoS) satisfaction ratio.
Deep Learning based Prediction of Vehicular Speed, Flow and Traffic Congestion using Real World Data
Authors: Shah Syed Ammad Ali
Published: February 2024

Accurate traffic congestion and flow prediction plays a crucial role in designing intelligent transport system (ITS) for vehicles in heterogeneous mobile networks. Traffic speed, flow and congestion prediction is a challenging task if limited attributes are used as input to predictive models or the prediction is done too late to take any appropriate action. Although several deep learning and machine learning approaches have been deployed to predict different traffic conditions, these approaches are based on the traffic observations at target location or its adjacent regions. Complex road networks, large data sets with multiple traffic features and analysis of spatial temporal dependencies of traffic data are not yet exploited in detail. In this study, a workflow consists of data acquisition, analysis, and exploitation of real-world time series traffic data is developed. We study number of data driven models namely, the long short-term memory (LSTM), gated recurrent unit (GRU) and hybrid CNN-LSTM model to predict traffic and compare it with the linear regression (LR) model. The deep learning models are capable of handling both spatial and temporal dependencies as well as the sudden changes in traffic speed and flow predicting the vehicular traffic accurately over long periods. The models are trained using the six months and three months of traffic flow, speed and occupancy data provided by the California Department of Transportation (Caltrans). The deep learning models outperform traditional linear regression method. Moreover, an architectural study of deep learning models is carried out for traffic prediction to discover the best structure for traffic congestion prediction. The performance of the models is evaluated using MSE and MAE metrics. It is concluded that the performance of deep learning models vary with the amount of historical data and sliding window size used for the traffic prediction. It is observed that a complex hybrid model like CNN-LSTM is not required for accurate prediction of the spatial and temporal tendencies when the training period is longer (six months). The GRU with much simpler architecture does not need to store road network and temporal information for long term in its memory, outperforms the LSTM and CNN- LSTM models. However, as the data size is reduced CNN-LSTM model out- performs the LSTM and GRU models for traffic congestion prediction.
Are Canadian and U.S. Based Direct-to-Consumer Genetic Testing Companies Complying with the ‘Accuracy Principle’ Outlined in PIPEDA?
Authors: Felice Victoria Di
Published: February 2024

The websites of 26 Direct-to-Consumer Genetic Testing (DTC-GT) companies based in the United States and or Canada selling health-related genetic testing services to Canadian residents were analyzed to determine whether the companies are complying with the ‘Accuracy Principle’ outlined in the ‘Personal Information Protection and Electronic Documents Act’ (PIPEDA). The main web pages of the DTC-GT companies’ websites along with their Privacy Policies and Terms of Service were examined to assess the statements made about the clinical and analytical validity of their genetic tests. The findings show that the majority of the DTC-GT companies’ websites (17 of 26) made contradictory statements relating to the accuracy of their genetic tests on one or more of their website tabs as compared to their Privacy Policies and Terms of Service. The results indicate that DTC-GT companies are not clearly articulating the limits to the requirement for accuracy, and their genetic tests are not sufficiently accurate for the purposes for which they are to be used, contrary to the requirements of Principles 4.6, 4.6.1 and 4.6.3 of the ‘Accuracy Principle’ outlined in PIPEDA.
Modelling and Energy Management Control Study for a Net Zero Energy Home
Authors: Caputo Diego
Published: February 2024

This study analysis an energy model developed for a net zero energy (NZE) home based on the building characteristics of the Archetype Sustainable House (ASH), located in Toronto (Ontario, Canada). The model presents a complete energy consumption profile which includes space heating/cooling, domestic hot water heating (DHWH), appliance/lighting, mechanical ventilation and electric-vehicle (EV) battery charging. The house heating and cooling demand was evaluated against actual heating and cooling load targets and the energy consumption over a full year was determined to have been modelled with 90.73% accuracy. Energy production was then introduced in the model and the distribution of energy consumption and generation over summer and winter solstice days were compared with a similar study. The results indicated that the net energy consumption and production deviation was approximately -18% for the summer season and 18% for the winter season. Lastly, a control study was developed to evaluate the energy performance achieved by implementing a rule-based (RB) control strategy, with traditional optimization, based on peak-load shedding, GHG emissions and TOU energy cost (EC). Battery utilization (BU) was analogised with control strategies performance and a correlation was identified. The results obtained from the altered energy consumption profiles showed a 79.8% and 21.5% improvement in peak load shedding, 2.35% and 7.63% increase in GHG emissions and 8.35% and 61.14% reduction in EC for the summer and winter seasons respectively.
Review of Thermal Energy Harvesting Opportunities in Buildings
Authors: Pinto Michael De
Published: February 2024

The building sector has a substantial energy demand for the requirements of hot water, space heating, ventilation, and air conditioning. Thermal energy is thus, a fundamental requirement thoroughly relied upon by the building sector. By exploiting thermodynamic principles, building science and freely available environmental energy, mechanical systems which synchronize with the natural environment can be implemented to efficiently, source and service thermal energy to the building environment.

Each employed mechanical system, purposed to harvest thermal energy will have a unique means of operation and feasibility. Estimation of practical efficiencies, alongside the results of energy simulation modelling can provide foresight on mechanical building system performance. With appropriate case studies, thermal energy harvesting, storage and recovery solutions can be verifiably implemented to achieve significant energy and greenhouse gas savings.
Grain Refinement of AZ91 Magnesium Alloy with a Novel Aluminum-Graphite Inoculant
Authors: Rinaldi Michael
Published: February 2024

Magnesium is a lightweight metal with a high strength-to-weight ratio, making it an ideal material for improving fuel efficiency. However, its poor mechanical properties necessitate the need for researchers to find ways of improving them for this material to find wider acceptance in industry. This study examines the grain refinement capabilities of an aluminum-carbon (graphite) composite in cast AZ91E magnesium alloy. With increasing carbon addition, ultimate tensile strength (UTS) and ductility improved, while yield strength (YS) remained largely unchanged. The fracture mechanism also remained unchanged with increasing carbon addition, showing mixed-mode fracture in samples of highest and lowest ductility. The nucleation mechanism was determined to be duplex nucleation of Al4C3 and Al8Mn5. X-ray diffraction analysis confirmed that the Al-C inoculant contained Al4C3 after sintering; however, most Al4C3 was formed in-situ during the melting and casting process.
Predicting Bicycle-on-Board Transit Choice in a University Environment
Authors: Rybarczyk Greg , Shaker Richard Ross
Published: February 2024

Bicycles-on-board (BoB) transit is a popular travel demand management (TDM) tool across many U.S. cities and universities, yet research on this mode within a university environment remains minimal. The purpose of this research is to investigate how personal and neighborhood factors influence this travel choice in a university setting. Relying on attitudinal data from a stated preference survey, this study examined the effect of personal characteristics and seven key neighborhood conditions on the willingness to utilize BoB for the “first mile” of the journey to campus. The study used exploratory spatial data analysis (ESDA), a discrete choice modeling framework, and geovisualizations to understand the likelihood of choosing this mode among a university population in Flint, Michigan, USA. The results revealed that the majority of constituents were not interested in BoB, aside from a cluster near the commercial business district. Also of note was that long commutes, and reduced access to parks and bicycle facilities dissuaded people from choosing this mode. Surprisingly, a neighborhood’s walkability or bikeability had no effect on respondent’s interest in using BoB. Lastly, the geovisualizations showcased where localized interventions may effectively increase this mode choice in the future.
Transfusion of ever-pregnant donor red blood cells and mortality of male patients
Authors: Valk Sarah J. , Caram-Deelder Camila , Groenwold Rolf. H.H. , Evers Dorothea , De Vooght Karen M.K. , Van de Kerkhof Daan , Wondergem Marielle J , Péquériaux Nathalie C.V. , Hudig Francisca , Zwaginga Jaap Jan , Middelburg Rutger A. , Van der Bom Johanna G.
Published: February 2024

Previous studies found exposure to red blood cell transfusions from female donors who have been pregnant reduces survival in male patients compared to exposure to male donor products, but evidence is not consistent. We postulate the previously observed association is modified by offspring sex, with an expected increased mortality risk for male patients receiving units from female donors with sons. Here, marginal structural models were used to assess the association between exposure to units from ever-pregnant donors, ever-pregnant donors with sons and ever-pregnant donors with daughters, and mortality. Clinical data were collected on first-ever transfusion recipients in the Netherlands and donor data were supplemented with information about offspring sex and date of birth. In this analysis, 56,825 patients were included, of whom 8,288 died during follow-up. Exposure to red blood cell units from everpregnant donors with sons was not associated with increased all-cause mortality risk among male transfusion recipients (hazard ratio [HR] 0.91, 95% confidence interval 0.83-1.01). Exposure to ever-pregnant donors, irrespective of offspring sex, was associated with mortality in male patients aged between 18 and 50 years (ever-pregnant donors: HR 1.81, 95% CI 1.31-2.51) compared to male donor units, but was protective in female patients. This study suggests that the observed increased mortality risk for exposure to red blood cell units from parous female donors does not depend on offspring sex. The increased risk of mortality seen in younger adult male patients is consistent with previous observations, but the underlying biological mechanism could not be identified in this study.
IELSG38: phase II trial of front-line chlorambucil plus subcutaneous rituximab induction and maintenance in mucosa-associated lymphoid tissue lymphoma
Authors: Stathis Anastasios , Pirosa Maria Cristina , Orsucci Lorella , Feugier Pierre , Tani Monica , Ghesquières Hervé , Musuraca Gerardo , Rossi Francesca Gaia , Merli Francesco , Guièze Romain , Gyan Emmanuel , Gini Guido , Marino Dario , Gressin Remy , Morschhauser Franck , Cavallo Federica , Palombi Francesca , Conconi Annarita , Tessoulin Benoît , Tilly Hervé , Zanni Manuela , Cabras Maria Giuseppina , Capochiani Enrico , Califano Catello , Celli Melania , Pulsoni Alessandro , Angrilli Francesco , Occhini Ubaldo , Casasnovas René-Olivier , Cartron Guillaume , Devizzi Liliana , Haioun Corinne , Liberati Anna Marina , Houot Roch , Merli Michele , Pietrantuono Giuseppe , Re Francesca , Spina Michele , Landi Francesco , Cavalli Franco , Bertoni Francesco , Rossi Davide , Ielmini Nicoletta , Borgo Elena , Luminari Stefano , Zucca Emanuele , Thieblemont Catherine
Published: February 2024

The IELSG38 trial was conducted to investigate the effects of subcutaneous (SC) rituximab on the complete remission (CR) rate and the benefits of SC maintenance in patients with extranodal marginal zone lymphoma (MZL) who received frontline treatment with chlorambucil plus rituximab.
Study treatment comprised an induction phase with chlorambucil 6 mg/m2/day orally on weeks 1-6, 9-10, 13-14, 17-18, and 21-22, and rituximab 375 mg/m2 intravenously on day 1 of weeks 1-4, and 1400 mg SC on weeks 9, 13, 17, and 21. Then, a maintenance phase followed with rituximab administered at 1400 mg SC every two months for two years.
Of the 112 patients enrolled, 109 were evaluated for efficacy. The CR rates increased from 52% at the end of the induction phase to 70% upon completion of the maintenance phase. With a median follow-up of 5.8 years, the 5-year event-free, progression-free, and overall survival rates were 87% (95% CI, 78-92), 84% (95% CI, 75-89), and 93% (95% CI, 86-96), respectively. The most common grade ≥3 toxicities were neutropenia (33%) and lymphocytopenia (16%). Six patients experienced treatment-related serious adverse events, including fever of unknown origin, sepsis, pneumonia, respiratory failure, severe cerebellar ataxia, and fatal acute myeloid leukemia.
The trial showed that subcutaneous rituximab did not improve the complete remission rate at the conclusion of the induction phase, which was the main endpoint. Nevertheless, SC maintenance might have facilitated long-term disease control, potentially contributing to enhanced event-free and progression-free survival.
A predictive classifier of poor prognosis in transplanted patients with juvenile myelomonocytic leukemia: a study on behalf of the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire
Authors: Meyran Déborah , Arfeuille Chloé , Chevret Sylvie , Neven Quentin , Caye-Eude Aurélie , Lainey Elodie , Petit Arnaud , Rialland Fanny , Michel Gérard , Plantaz Dominique , Jubert Charlotte , Theron Alexandre , Gandemer Virginie , Ouachée-Chardin Marie , Paillard Catherine , Bruno Bénédicte , Buchbinder Nimrod , Pochon Cécile , Calvo Charlotte , Fahd Mony , Baruchel André , Cavé Hélène , Dalle Jean-Hugues , Strullu Marion
Published: February 2024

Juvenile myelomonocytic leukemia (JMML) is an aggressive pediatric myeloproliferative neoplasm requiring hematopoietic stem cell transplantation (HSCT) in most cases. We retrospectively analyzed 119 JMML patients who underwent first allogeneic HSCT between 2002 and 2021. The majority (97%) carried a RAS-pathway mutation, and 62% exhibited karyotypic alterations or additional mutations in SETBP1, ASXL1, JAK3 and/or the RAS pathway. Relapse was the primary cause of death, with a 5-year cumulative incidence of 24.6% (95%CI: 17.1-32.9). Toxic deaths occurred in 12 patients, resulting in treatmentrelated mortality (TRM) of 9.0% (95%CI: 4.6-15.3). The 5-year overall (OS) and event-free survival were 73.6% (95%CI: 65.7-82.4) and 66.4% (95%CI: 58.2-75.8), respectively. Four independent adverse prognostic factors for OS were identified: age at diagnosis >2 years, time from diagnosis to HSCT >6 months, monocyte count at diagnosis >7.2x109/L, and the presence of additional genetic alterations. Based on these factors, we proposed a predictive classifier. Patients with three or more predictors (21% of the cohort) had a 5-year OS of 34.2%, whereas those with none (7%) had a 5-year OS of 100%. Our study demonstrates improved transplant outcomes compared to prior published data, which can be attributed to the synergistic impacts of a low TRM and a reduced yet still substantial relapse incidence. By integrating genetic information with clinical and hematological features, we have devised a predictive classifier. This classifier effectively identifies a subgroup of patients who are at a heightened risk of unfavorable post-transplant outcomes who would benefit novel therapeutic agents and post-transplant strategies.
The unexpected and unresolved roles of PDGFRA and PDGFRB in T-cell acute lymphoblastic leukemia
Authors: Verhoeft Krista , Cools Jan
Published: February 2024

Not available.
Aleteo auricular: caso clínico
Authors: Banegas Santos Evelyn Johanna , Mendoza Rivas Rodrigo José , Yunga Corte Aida Marlene
Published: February 2024

Introducción.  El aleteo auricular es una enfermedad que no pone en peligro la vida y puede ser muy sintomática debido a las altas frecuencias ventriculares que normalmente ocurren. El diagnóstico es fácil porque solo se requiere un ECG de 12 derivaciones. En pacientes que no pueden revertir o prevenir el aleteo, se puede intentar con éxito la resección del nódulo aurícula ventricular y la implantación de un marcapasos permanente. Las técnicas de ablación por radiofrecuencia ahora son muy exitosas para revertir el aleteo auricular y prevenir su inducibilidad y recurrencia. Objetivo: Determinar el manejo de la patología aleteo auricular para presentar aspectos nuevos o instructivos de la enfermedad. Metodología: estudio de caso clínico de tipo descriptiva, retrospectivo. La técnica que se utilizó para la recolección de la información del caso fue mediante la revisión de historia clínica y para la descripción de la patología será mediante la recopilación de artículos extraídos de bases de datos reconocidas como: Scopus, PorQuest, Pubmed, web of science, lilacs. Como criterio de inclusión: artículos publicados en los últimos 5 años, en español e inglés. El caso cuenta con el consentimiento informado del paciente para dar cumplimiento a lo establecido por Bioética. Resultados: Se identificaron las principales causas, síntomas y signos, el diagnóstico, tratamiento y prevención del aleteo auricular, como personal de salud es de vital importancia adquirir nuevos conocimientos sobre esta patología que afecta con más frecuencia a adultos. Conclusiones: El mayor riesgo de desarrollar aleteo auricular son los hombres, los ancianos y las personas con insuficiencia cardíaca preexistente o enfermedad pulmonar obstructiva crónica es por ello que nuestro estudio fue aplicable el tratamiento con antiarrítmicos, además de anticoagulantes. Área de estudio general: medicina. Área de estudio específica: cardiología. Tipo de estudio: Casos clínicos.
Estenosis Mitral: Caso Clínico
Authors: Cárdenas Álvarez Adriana Marisela , Salas Contreras Francy Hollminn , Moyano Brito Edisson Gustavo
Published: February 2024

Introducción. La estenosis y la insuficiencia pulmonar, son patologías que ocasionan alteraciones en el flujo de sangre dentro de las cavidades derechas del corazón. Se presentan mayoritariamente como defectos congénitos, pero en una gran cantidad de pacientes no son diagnosticadas sino hasta llegar a la edad adulta; debido a la poca sintomatología que usualmente presentan y debido al gran periodo de latencia que tienen de forma asintomática. Objetivo. Determinar las principales manifestaciones clínicas y los métodos diagnósticos de las patologías de la válvula pulmonar a través de un caso clínico, con el fin de ayudar a facilitar sus diagnósticos tempranos. Metodología.  Estudio de caso clínico de tipo descriptivo, retrospectivo. La recolección de la información del caso se realizará mediante la revisión de la historia clínica. La expectativa del siguiente trabajo de investigación es identificar las principales causas, síntomas y signos, el diagnóstico, tratamiento y prevención de la estenosis e insuficiencia pulmonar. Resultados. Presentamos el caso de una femenina de 34 años edad con antecedente de valvulopatía pulmonar en la infancia y 24 horas de evolución de disnea más dolor retroesternal. Se realizan los exámenes complementarios y se diagnostica una estenosis con insuficiencia pulmonar. Se Realiza una cirugía de reemplazo valvular y es dada de alta con buen pronóstico. Conclusión. La principal manifestación de las enfermedades de la válvula pulmonar son manifestaciones características de insuficiencia cardiaca derecha y retención de líquidos. El principal estudio diagnóstico de las enfermedades de la válvula pulmonar es la ecocardiografía más estudio Doppler. El tratamiento de elección en estenosis e insuficiencia pulmonar cuando los síntomas son graves es el reemplazo valvular. Las enfermedades valvulares pulmonares cuando son diagnosticadas correctamente e intervenidas a tiempo, suelen tener una remisión muy buena y el pronóstico es favorable. Área de estudio general: medicina. Área de estudio específica: cardiología. Tipo de estudio: Casos clínicos.
Diversity of Plant Species in Moringa-Based Homestead of Jaintiapur Upazila in Sylhet District
Authors: Prova S J , Ahsan Talucder Mohammad Samiul , Uddin Md Sharaf
Published: February 2024

Homestead agroforestry is crucial for food, fiber, and other necessities which are required outside the conventional forests. Thus, homestead agroforestry meets the criteria for a sustainable forest management scheme, providing a better way for biodiversity conservation. Moringa based homestead agroforestry in Sylhet has an opportunity to encourage species diversity for its various structural properties. This paper explores the plant species diversity of Moringa based homestead area at Jaintiapur upazila in Sylhet. Personal interviews were conducted from June 2022 to September 2022 with 40 randomly selected respondents who were involved in Moringa-based homestead agroforestry. Shannon-Wiener Diversity Indices (SWDI) was used to explore the plant species diversity index. In the study area identified plant species were 50.0% fruits, 26.3% vegetables, 15.8% timber and 7.9% medicinal plants. Among all the plant species, the higher diversity was found in fruit species followed by timber species, vegetable species and medicinal species. Most of plant species were found in boundary side of homestead area. Vegetable plant diversity was found high (Hʹ = 0.94-0.72), fruit species was also high (Hʹ = 0.99-0.69), medicinal species was medium to high (Hʹ = 0.62-0.97) and timber plant species was high (Hʹ =0.86-0.94) in different homestead areas. It may be concluded that plant species diversity as observed in Moringa based homestead area could be a good option for biodiversity conservation in Sylhet area of Bangladesh.
SAARC J. Agric., 21(2): 119-129 (2023)
Impacts of COVID-19 on Livestock Production in Sudur Paschim Province of Nepal: Assessing Government Interventions and Lessons Learned
Authors: Sedai Dilli Ram , Bhatta K L , Bhattrai M , Techato K A , Yuangyai U
Published: February 2024

This study examines the influence of COVID-19 pandemic on livestock sectors in Sudur Paschim Province (far western province) of Nepal with a focus on the government's response. Analyzing provincial interventions in the livestock sector, we present findings from a primary survey and interviews with livestock farmers, agri-business traders, market agents, and key stakeholders across Kanchanpur, Kailali, Doti, and Achham districts. These districts represent the diverse agro-climatic conditions of far western Nepal. Using mixed methods, we combine qualitative and quantitative data to analyze the impact on livelihoods, business performances, employment, and income for livestock farmers and traders compared to the pre-pandemic scenario of 2019. The pandemic significantly disrupted the livestock and fresh meat production system due to supply chain disruptions, affecting all stakeholders – farmers, producers, suppliers, traders, agro-businesses, and consumers. The repercussions varied among these actors. Dairy farmers experienced a 50-60 percentage income loss, while poultry farmers had to sell birds at half price. The dairy, poultry, and fish sub-sectors were particularly hard-hit. Despite government support, assistance primarily reached well-off farmers and larger businesses rather than smallholders. This study not only underscores lessons learned for Nepal in managing the pandemic and similar disasters but also offers insights for other countries in South Asia facing comparable constraints and opportunities. By investigating the pandemic's repercussions and government interventions in Nepal, this research contributes to better preparedness and response strategies for future crises in livestock and agriculture.
SAARC J. Agric., 21(2): 217-226 (2023)
Genetic variability, correlation and path analysis for yield and its contributing traits in Barley (Hordeum vulgar L.)
Authors: Kobir MS , Rashid MHO , Halder D , Rahman M , Akter MS , Hossain MS , Nasim FA , Paul S , Ahammad KU
Published: February 2024

In breeding programs, direct selection based on crop yields is paradoxical due to its complex polygenically inherited nature, that is impacted by its component traits. To determine the degree of relationship between yield and yield components and other traits in nine barley varieties, a field experiment was carried out at the Regional Agricultural Research Station, Jashore during Rabi 2021–2022. For plant height, disease and insect reaction, and grain yield, substantial heritability together with strong genetic progress as a percentage of mean were detected, indicating a prevalence of additive gene action in the expression of these traits. At both the genotypic and phenotypic levels, the correlation coefficient between grain yield was shown to be positively correlated with plant height and thousand grain weight, indicating that an increase in these traits will boost grain production. Both genotypic and phenotypic analysis of the path coefficient demonstrated that plant height and thousand grain weight had a direct positive impact on grain production, highlighting the significance of these parameters as the primary contributors to yield. For the purpose of genetically improving barley yield, a genotype with a higher extent of these qualities could be chosen as a parent from among genotypes that already exist.
SAARC J. Agric., 21(2): 15-25 (2023)
Fatores associados à morbimortalidade da Síndrome da Imunodeficiência Adquirida (AIDS) em pessoas privadas de liberdade
Authors: Magalhães Maria Vitória Frota , Vicente Andressa Gonçalves , Gomes Geicimara Emanuele da Silva , Del Bianco Débora , Palhares Carlos Vinícius Teixeira , Ruela Guilherme de Andrade
Published: February 2024

Objetivo: Avaliar os fatores associados à morbimortalidade da síndrome da imunodeficiência adquirida (AIDS) em pessoas privadas de liberdade. Metodologia: Trata-se de uma revisão integrativa da literatura, com buscas nas bases de dados: Scientific Electronic Library Online (SciELO), Medical Literature Analysis and Retrieval System Online (Medline) e Literatura Latino-Americana e do Caribe em Ciências da Saúde (Lilacs). Os descritores utilizados consistiram em "Acquired Immunodeficiency Syndrome" e "Prison", combinados com o operador booleano AND. Os critérios de inclusão consideraram estudos referentes ao período entre 2018 e 2023, disponíveis na íntegra. Artigos não relacionados ao tema proposto foram excluídos. Resultados: Considerando os critérios dispostos, foram selecionados 11 artigos, dentre os 58 encontrados. Discussão: Destacaram-se aspectos de saúde, enfatizando a associação entre a morbidade da AIDS e variáveis como hepatite, tuberculose, abuso de drogas e coinfecções. Fatores sociais, econômicos e educacionais também foram abordados, indicando o impacto de prisões superlotadas, baixo nível socioeconômico e falta de educação sexual. A análise da literatura selecionada ressalta a vulnerabilidade dos indivíduos encarcerados e a necessidade de atenção específica para prevenir a disseminação do HIV. Conclusão: A morbimortalidade por HIV em prisões está relacionada a fatores de saúde, econômicos e sociais, incluindo práticas de risco como tatuagens e compartilhamento de seringas. Destaca-se a necessidade de pesquisas adicionais que visem compreender o perfil epidemiológico.
Cartografia no contexto da Estratégia Saúde da Família: Caminhos possíveis a partir do georreferenciamento
Authors: Sampaio Daniela Márcia Neri , Pires Vilara Maria Mesquita Mendes , Cairo Gabriel Magalhães
Published: February 2024

Objetivo: relatar a experiência de uma oficina sobre cartografia no contexto da Estratégia Saúde da Família, que utilizou o georreferenciamento como ferramenta prática. Métodos: Trata-se de um estudo qualitativo, descritivo, do tipo relato de experiência, que ocorreu em um município baiano, com encontros semanais durante o mês de novembros 2021, com 39 participantes. Foi utilizado o método Problem Based Learning (PBL) e um momento de prática para a construção dos mapas inteligentes para cada equipe, com base no manual Qualifica APS: Tutorial para georreferenciamento da APS através da ferramenta Google Maps. Resultados: A oficina possibilitou trabalhar conceitos como territorialização na Atenção Básica, mapeamento, cartografia e georreferenciamento, com críticas e reflexões sobre a importância do trabalho em equipe, em uma perspectiva Interprofissional e colaborativa, que propiciou também estimular a criatividade dos participantes. Conclusão: A oficina desvelou que o uso da tecnologia pode ser uma barreira, mas o desenvolvimento do trabalho colaborativo pode trazer leveza na implementação do trabalho em saúde. Fez perceber que ao adotar o uso dos mapas inteligentes poderá propiciar um processo contínuo de atualização do trabalho na Estratégia Saúde da família.
Sobre os desenhos de usuários de uma emergência psiquiátrica
Authors: Coelho Junior Leconte de Lisle
Published: February 2024

Dentre as diversas formas de prescrutar a mente humana, o desenho é das mais antigas e, portanto, válido para compreender a subjetividade. A partir das pistas que a arte intramuros apresenta, cabe aos profissionais de saúde buscar meios de diluir o sofrimento psíquico e ajudar a estabilizar o usuário. Este estudo derivou de um projeto de extensão realizado em uma ala de emergência psiquiátrica de uma instituição hospitalar pública paraibana. Sendo assim, o objetivo deste manuscrito é refletir sobre os desenhos dos usuários daquele serviço. Durante diversas atividades, foram produzidos um total de 219 escorços, sendo 160 obras gráficas pré-produzidas, 53 desenhos dos próprios utentes, e, 6 colagens, provenientes de cerca de 61 usuários. Como resultado, se pode compreender que os desenhos desempenham uma forma daquelas pessoas expuserem suas histórias pessoais, a história da doença e também traços de sintomas psicopatológicos. Cabe aos profissionais da saúde mental, entre eles os psicólogos, criar formas de manejo que direcionem os usuários à reabilitação psicossocial tendo os desenhos como base para as orientações cabíveis.
Treatment of complicated bacterial pneumonia in children
Authors: Freire Tayná de Freitas , Souza Emanuelle Cordova de , Jucá Neto José de Ribamar Barroso , Silva Manuella Mendonça da , Morais Pedro Iughetti , Sousa Yasmim Cavalcante , Rocha Caio César Otôni Espíndola
Published: February 2024

Introduction: Community-acquired pneumonia (CAP) is one of the most common infectious diseases in pediatrics, and may be related to the direct occurrence of local complications such as empyema, necrotizing pneumonia, lung abscess or pleural effusion, which are directly related to worsening of the clinical aspect and prolongation of the hospitalization period. Methodology: A narrative review of the literature was carried out in the PUBMED database, using the following keywords: “Bacterial pneumonia in children”, “Complicated Pneumonia” and “Treatment”, with the time filter for the last 5 years (2019-2023). Results: From the research carried out, 408 articles were identified, of which, after applying inclusion and exclusion criteria, 12 were selected for analysis. Discussion: The main complications are related to specific complementary exams and assertive surgical or antimicrobial therapies that seek to avoid mortality, exacerbation of other complications and reduce hospitalization time and associated morbidities. Conclusion: Knowledge about the complications of community-acquired pneumonia, particularly its course of development and its propaedeutic approach, helps to alleviate the difficulties of the clinical context and provide more security to the doctor in his/her healthcare assistance to the patient.
EFEKTIVITAS METODE MENDONGENG UNTUK MENUMBUHKAN MINAT BACA ANAK USIA DINI
Authors: Siska Marini Raden , Rosita Rosita
Published: February 2024

The purpose of this study was to find out how effective the storytelling method was to increase early childhood interest in reading. This research is a library research. The description of the data in this study is in the form of a record of all findings regarding the effectiveness of storytelling activities in any research discussion obtained in the literature and sources, also the latest findings regarding increasing early childhood reading interest. The results of this study indicate that the effective storytelling method for increasing interest in reading in early childhood because it is based on the results of the analysis of language development theories and theories of children's brains. Storytelling is a fun activity that can develop children's imagination curiosity. So when children have a high curiosity. Then the child will seek knowledge one of them through reading.