bluuebunny/crossref_metadata_2025 huggingface dataset:
МОДЕЛЮВАННЯ ДВОСЕКТОРНОЇ ЕКОЛОГІЧНОЇ ЕКОНОМІКИ З УРАХУВАННЯМ СПЕЦИФІКИ ПОВЕДІНКОВИХ ФУНКЦІЙ У ВИРОБНИЦТВІ ТА СПОЖИВАННІ
Authors: Григорків В.С. , Григорків М.В.
Published: May 2022

Розкрито актуальність проблем екологізації виробництва, споживання та економіки у цілому.Обґрунтовано необхідність системного дослідження цих проблем з метою розробки сценаріївстановлення та розвитку екологічно та соціально збалансованої економіки. Запропоновано динамічнумодель двосекторної екологічної економіки, у якій один сектор займається виробництвом основноїагрегованої продукції, а інший – утилізацією продуктів забруднення, створених у виробництві кожногоіз секторів, а також під час споживання основної продукції. У теоретичному плані модель можеслужити для якісного аналізу концептуальних і методологічних підходів до формалізації динамічнихсистем, а також принципів їх моделювання, а у прикладному – вона призначена для дослідження урежимі комп’ютерної імітації траєкторій еколого-економічної динаміки та підтримки процесівприйняття управлінських рішень в економіці. Експериментальні дослідження з моделлю та їїмодифікаціями, крім аналізу особливостей поведінки еколого-економічних систем, дозволяють такожвдосконалити специфікацію моделі, ідентифікацію окремих її параметрів, зміст і можливостівідповідного інформаційного та програмного забезпечення для її апробації та застосування.
ЦИФРОВІЗАЦІЯ ЯК ІННОВАЦІЙНИЙ ПІДХІД ДО РЕАЛІЗАЦІЇ ФУНКЦІЙ УПРАВЛІННЯ СОЦІАЛЬНО-ЕКОНОМІЧНИМИ СИСТЕМАМИ
Authors: Мельник В.І. , Мазур В.Г. , Мазур Ю.С.
Published: May 2022

У статті розкрито питання цифровізації суспільства з позиції інноваційного підходу до реалізаціїфункцій управління соціально-економічними системами. Визначено аспекти функціонального впливудержавних органів влади в інноваційній сфері. Досліджено способи взаємодії в межах формуваннясоціально-економічних відносин через застосування інноваційних технологій. Обґрунтованофункціональну складову інновацій для забезпечення ефективної реалізації процесів управління соціально-економічними системами.
PERANCANGAN SISTEM DATA TAGIHAN JARINGAN INTERNET PADA BUMDES KARYA ABADI DESA NGETUK BERBASIS WEBSITE DAN MEMANFAATKAN CLOUD SMS GATEWAY
Authors: Hanafi Endri , Fiati Rina , Wijayanti Esti
Published: May 2022

Ngetuk Village Has a business unit, namely BUMDes Karya Abadi, one of the businesses owned by BUMDes is a Fiber Optic internet network unit, where this internet is used as internet access for Ngetuk Village by means of BUMDes channeling internet via Fiber Optic cables which are distributed to the homes of residents who want to subscribe. This business unit has been running in Ngetuk Village, but the processing of billing data is still manual, with the Design of a Website-Based Internet Network Billing Data System and Utilizing Cloude SMS Gateway. The system design uses the Waterfall method, uses the PHP programming language and mySQL database, with the creation of the system, it is hoped that it will make it easier for officers to record internet bills. The results obtained are the Design of Internet Network Billing Data System at BUMDes Karya Abadi Ngetuk Village Website-Based and Utilizing Cloud SMS Gateway.Keywords: BUMDes, Design, Website, Cloude SMS Gateway, PHP, mySQL
"Approaches to the relationship between communication and design in 21st century Mexico: understanding information design"
Authors:   ", Romero Lombardini Josefina ,   UNIVERSIDAD AUTÓNOMA METROPOLITANA UNIDAD CUAJIMALPA"
Published: May 2022

This book tries to be for the reader a space that allows to collect oxygen and reflect on the change and the need for a fundamental transformation in the teaching of communication and design under the protection of global conditions and demands in which they are inscribed today. The changes we are generating impact on the way in which we build information about reality, facilitating or preventing the way we understand them and reflect on how to adapt to them as a collectivity and as individuals. It is necessary to list some of these changes and events that are highly significant for the social, scientific and technological evolution that we are living in the second half of that century. This implies assuming a transformation also in the paradigms of design, since this is an essentially communicative product, specifically inscribed in communication.
LLVM Instruction Latency Measurement for Software-Hardware Interface for Multi-many-core
Authors: Mikami Hiro , Torigoe Kei , Inokawa Makoto , Edahiro Masato
Published: May 2022

The increasing scale and complexity of embedded systems and the use of multi-many-core processors have resulted in a corresponding increase in the demand for software development with a high degree of parallelism. The degree of parallelism in software and the accuracy of performance estimation in the early design stages of model-based development can be improved by estimating performance of blocks in models and utilizing the estimate for parallelization. Research is therefore being performed on a software performance estimation technique that uses the IEEE2804-2019 hardware feature description called software-hardware interface for multi-many-core (SHIM). In SHIM, each LLVM-IR instruction is associated with the execution cycle of the target processor. Because several types of assembly instruction sequences for the target processor are generated from a given LLVM-IR instruction, it is not easy to estimate the number of execution cycles. In this study, we propose a regression analysis method to estimate the execution cycles for each LLVM-IR instruction. It is observed that our method estimated the execution cycles within the target error of ±20% in experiments using a Raspberry Pi3 Model B+.
Hesitant Fuzzy Prime Ideal of Γ- ring
Authors: Karim Mazen Omran , Ghanim Rand Shafea
Published: May 2022

In this paper, we introduce the notions of hesitant fuzzy ideal, hesitant fuzzy prime ideal, hesitant fuzzy strongly prime ideal in gamma rings and hesitant 3-prime ideal. Also, we study the relation between the above concepts
SINIF ÖĞRETMENİ ADAYLARININ ÖZEL EĞİTİM UYGULAMA OKULUNDAKİ ÖĞRENCİLERLE OKUL DENEYİMİNE KATILMASININ ETKİLERİNE İLİŞKİN GÖRÜŞLERİN İNCELENMESİ
Authors: YAZICI Mahmut Serkan , CUMALI Damla
Published: May 2022

Günümüzde birçok sınıf öğretmeni kaynaştırma uygulaması kapsamında özel gereksinimli öğrenciler ile çalışmaktadır. Lisans eğitiminin öğretmenlik mesleki yeterliği açısından önemi düşünüldüğünde, sınıf öğretmeni adaylarının teorik bilgi kadar uygulamaya yönelik eğitim de alması bir ihtiyaçtır. Bu araştırma, sınıf öğretmeni adaylarının özel gereksinimli öğrencilerle okul deneyimine katılmasına ilişkin görüşlerinin incelenmesi amacıyla planlanmıştır. Çalışma, durum çalışması yöntemiyle gerçekleştirilmiştir. Araştırmanın örneklemini sınıf öğretmenliği ikinci sınıf öğrencisi olan 25 sınıf öğretmeni adayı ve özel eğitim uygulama merkezinde çalışmakta olan 11 öğretmeni (10 öğretmen ve 1 müdür yardımcısı) kapsamaktadır. Sınıf öğretmeni adaylarının özel gereksinimli öğrencilerle okul deneyimini katılmasına yönelik görüşlerinin alınmasında yapılandırılmamış gözlemin yanı sıra, okul deneyiminin öncesi ve sonrasında uygulanmak için geliştirilen anket formları kullanılmıştır. Okul deneyimi sürecinde sınıf öğretmeni adaylarıyla sürecin içerisinde olan öğretmenlerin görüşleri yarı yapılandırılmış görüşme yoluyla alınmıştır. Verilerin analizinde betimsel analiz kullanılmıştır. Araştırmanın sonucunda; sınıf öğretmeni adaylarının mesleğe başlamadan önce özel gereksinimli öğrencilerle okul deneyimine katılmalarının, kişisel ve mesleki gelişime fayda sağladığı sonucuna ulaşılmıştır. Bu noktada, sınıf öğretmeni adaylarının özel gereksinimli öğrencilere ve onlarla yürütülecek eğitime yönelik farkındalıklarında gelişim olduğu da belirtilmelidir. Bu araştırma kapsamında ayrıca, okul deneyiminin niteliğini arttırmaya yönelik katılımcı önerileri de yer almaktadır
ÖZEL ÖĞRENME GÜÇLÜĞÜ OLAN ÖĞRENCİLERİ TANILAMAYA YÖNELİK MODELLER VE TÜRKİYE’DEKİ DURUM
Authors: FIRAT Tahsin , BİLDİREN Ahmet
Published: May 2022

Öğrenme güçlüğü olan öğrencilerin erken ve doğru tanılanması ile ilgili problemler güncelliğini korumaktadır. Son 50 yıllık deneyimler öğrenme güçlüğü olan öğrencilerin tanılanmasında farklı bakış açılarının oluşmasına neden olmuştur. Bu süreç boyunca yaygın olarak IQ-Başarı Tutarsızlığı, Müdahaleye Yanıt ve Güçlü ve Zayıf Yönler Örüntüsü Modellerinin öğrenme güçlüğü olan öğrencileri tanılamada kullanıldığı görülmektedir. Kullanılan her bir modelin öğrenme güçlüğü olan öğrencileri tanılamada belirli avantajlarının ve dezavantajlarının olduğunu söylemek mümkündür. Bu modellerin özelliklerinin, avantajlarının ve dezavantajlarının ayrıntılı bir şekilde ortaya konulması öğrenme güçlüğü olan öğrencilerin doğru tanılanmasına katkı sağlayacaktır. Türkiye’nin öğrenme güçlüğü olan öğrencilerin tanılanmasındaki problemlerin üstesinden gelebilmesi için uluslararası alanyazında yer alan deneyimlerden faydalanması gerekmektedir. Bu doğrultuda öğrenme güçlüğü olan öğrencilerin tanılanmasında Hibrit olarak ifade edilen karma modeller önerilmektedir.
YETİŞKİNLERDE BENLİK SAYGISI VE AFFETME: MERHAMETİN ARACI ROLÜNÜN İNCELENMESİ
Authors: YILDIRIM Hacer , BATMAZ Hasan , ÖZYURT UYSAL Yazgülü Ayşe , KURTULUŞ Emin
Published: May 2022

Bu araştırmanın amacı, (a) yetişkinlerin benlik saygısı, affetme ve merhamet düzeyleri arasındaki ilişkileri, (b) benlik saygısı ile affetme arasında merhametin aracı rolünün olup olmadığını incelenmektir. Araştırmanın çalışma grubu, 17-45 yaş aralığında 216’sı kadın (%74,2) ve 75’i (%25,8) erkek olmak üzere toplam 291 kişiden oluşmaktadır. Araştırmada kolay ulaşılabilir örnekleme yöntemi kullanılmıştır. Öncelikle bütün değişkenlere ilişkin betimsel istatistikler hesaplanmış, değişkenler arası ilişkiler Pearson Çarpım Momentler Korelasyon analizi kullanılarak belirlenmiştir. Aracılık analizleri Preacher ve Hayes’in önerileri doğrultusunda gerçekleştirilmiştir. Dolaylı etkilerin anlamlılığını incelemek için Preacher ve Hayes’in bootstrapping prosedürü kullanılmıştır. Bu araştırmada 10000 bootstrap yapılarak bootstrap katsayısı ve güven aralıkları belirlenmiştir. Elde edilen bulgulara göre, benlik saygısı ile affetme arasındaki ilişkide merhametin kısmi aracı etkisinin olduğu saptanmıştır. Merhamet, benlik saygısının affetme üzerindeki etkisinin düşmesinde anlamlı bir etkiye sahiptir.
Tilt-Strain Changes Linked to a Jacking System Test
Authors: Gambino Salvatore , Falzone Giuseppe , Ferro Angelo , Laudani Giuseppe , Scuderi Luciano
Published: May 2022

A sector of the San Marco Hospital (Catania, Italy) was the subject of a jacking test in order to demonstrate the substitutability of the seismic isolator. A monitoring system, included tiltmeters and strain gauges, was applied to one column. Two distinct behaviours have been identified during the unloading stage, the first in which the column and the roof are still attached and a second in which the detachment takes place. The jacking system caused the column to return to its original position, induced by the building structure for thermoelastic causes.
Shear Strength Properties of Coarse-Grained Soils Determined Using Large-Size Direct Shear Test
Authors: Stacho Jakub , Sulovska Monika
Published: May 2022

The paper deals with an analysis of the shear strength behaviour of coarse-grained materials using large-sized direct shear apparatus. The shear strength curve of compacted coarse-grained material allows for determining the three typical shear strengths, i.e. the shear strength for a maximum density of the sample tested (shear strength at point A), the peak shear strength (shear strength at point P), and the critical shear strength achieved for a large horizontal movement (shear strength at point C). Professional laboratories usually apply for determining the critical shear strength two different methods. The first method considers the critical shear strength at point A and the second method considers the critical shear strength at point C. The aim of the article is not to critically evaluate both methods, but to analyze the results of shear tests of gravels. The results of a large series of tests showed that these stresses may differ from each other in some cases, especially for poorly graded materials. In the case of sandy soil, the shear strength at point A and at point C is equal. However, in the case of poorly graded gravel, the shear strength at point C is greater than the shear strength at point A. The greatest difference between these shear strengths was measured in the case of poorly graded medium gravels. The results showed that the ratio of shear strength at point C to the shear strength at point A increases with increasing the grain size of the material tested. The peak as well as the critical shear strength parameters of poorly graded gravels is better represented by a multi-linear or a nonlinear failure line.
Seismic Response Analysis of Shear Buildings Using Waves
Authors: Abdul Rahman Ammar A.
Published: May 2022

A method of using waves instead of modes for analyzing the seismic response of buildings is presented. Instead of using the general procedure of response spectra to quantify the seismic hazard of a building a wave response function is used. An important aspect of this approach is that the wave model can describe building response using only four parameters namely, the stiffness, wave speed, time delay, and normalized distance and are shown to be enough to describe the full building response. The method presented is limited to responses due to ground motions from earthquakes and the building response to be predominately in shear. The wave analysis method proposed can be used for variable structure stiffness with uniform and non-uniform damping cases. Comparison using response spectra for a typical shear building is presented and discussed. The strength of the wave function approach is that it provides more information about the response of the specific shear buildings than the response spectra approach. As one of the findings from the analysis using waves is that the maximum strain in a shear building with variable stiffness and non-zero damping is related to the maximum velocity of the ground motion and not the maximum acceleration.
U.S.-UK Voting Cohesion in the United Nations General Assembly: Important Votes (2001–2019)
Authors: Mamedova A. O.
Published: May 2022

The article analyzes US-UK voting cohesion in the United Nations General Assembly in 2001 – 2019 based on the annual lists of important votes drawn up by the US Department of State. Voting cohesion in the UNGA demonstrates the level of support for US policies in this representative international forum. Since most UNGA resolutions are not binding, countries have more room for maneuver compared to voting in the UN Security Council. Washington pays close attention to other countries’ voting behavior in the UNGA, especially when it comes to Israel-related issues. Whereas the Anglo-American Special Relationship has been extensively studied with the focus on the military and political aspects, US-UK interaction in international organizations, especially in the UN, deserves greater attention. Both countries use their permanent membership of the Security Council to promote their interests. Nevertheless, US-UK voting cohesion in the UNGA has not attracted much attention yet, although it can help to objectively assess the interaction of these powers in the world arena. Four groups of important resolutions were identified for comparison: human rights, Israeli-Palestinian conflict, nuclear non-proliferation and international security, as well as sanctions and development. In 2001 – 2019 U.S.-UK voting cohesion on important resolutions was relatively high. Nevertheless, under Republicans George W. Bush and Donald Trump it was lower than during Barack Obama’s presidency. Despite the special relationship, the UK often aligns itself with the EU countries when voting in the UNGA. We paid special attention to resolutions on which the countries diverged, although Washington did not vote in complete isolation. U.S.-UK cohesion was higher on non-proliferation and human rights. At the same time, there were differences regarding the Israeli-Palestinian conflict and development, especially in those cases when the US and the EU disagreed. Divergences were apparent when the US was prone to act unilaterally.
Strengthening Russia’s International Prestige during the Northern War: Russian Diplomatic Institutions and Instruments
Authors: Topychkanov A. V.
Published: May 2022

During the Northern War (1700-1721), the Russian government had to make great efforts to strengthen the anti-Swedish coalition. Peter the Great developed a broad foreign network of state representatives: employees of the diplomatic corps (envoys, ministers, residents, agents, etc.), trade commissioners, and correspondents. Peter the Great himself, his Cabinet, and the foreign policy department (Posolsky Prikaz, Collegia Inostrannykh Del) controlled these agents of influence. Peter’s diplomats fought for symbolic capital by taking part in official negotiations and unofficial meetings, in diplomatic and court ceremonies, in gift-exchanging, and organizing various festivities. This capital then was converted into the international prestige of the ruler, his title, honor, glory, and position in the hierarchy of European rulers. Considerable attention was paid to promptly inform Western partners about events in Russia’s foreign and domestic policy. Russian information policy emphasized the news that can strengthen Russia’s international prestige: dynastic, diplomatic, and military successes, political reforms, and court celebrations. The article examines the practice of news dissemination through Russian diplomatic missions and foreign diplomatic representatives in Russia. The practice reduced the negative effect of the spread of unofficial information, fake news, and false rumors. The war continued in the pages of print media. To limit the dissemination of information damaging Russia’s prestige, Russian diplomats began to use the same instruments of influence (newspapers, magazines, and pamphlets), which European diplomats used at that time: various methods of pressure and bribery, propaganda, and censorship. The successes of Russian diplomacy have led to the strengthening of Russia’s international prestige and contributed to creating a positive image of the country abroad. The Russian government transferred the gained experience into domestic policy. Peter the Great also demanded fighting against “reprehensible” information about “the person of his majesty, or his troops, as well as his state.”
Letters of Friedrich Christian Weber to John Robeson from Russia, 1718-1719
Authors: Fedyukin I. I. , Novikova A. D.
Published: May 2022

The article examines the correspondence of the Hanoverian resident in Russia Friedrich Christian Weber over the period from January 1718 to the spring of 1720. The set of letters includes over two hundred reports written by the diplomate in French and currently deposited in the French Manuscripts collection of the Bodleian Library of the University of Oxford. The goal of this article is to present this source to the scholarly audience and to offer its preliminary analysis. Although Weber was formally a Hanoverian resident, he represented the interests of England, because the Elector of Hanover, since 1714, was also the monarch of Great Britain. The addressee of Weber’s letters was John Robethon, George I's diplomatic secretary. The article examines various aspects of Weber's diplomatic activities, including the methods he used to collect information in Russia and send it to England, such as bribing Russian officials, resorting to secret agents, ciphers, sending dispatches “under the cover, and others. The letters also reflect the tasks set before him by his government, first of all, investigating the nature of relations between the Russian court and the Jacobites and monitoring the progress of the Congress of Åland, including the views of the Russian and Swedish courts regarding the prospects of a separate peace treaty between them. The article also considers Weber’s approach to the analysis of the international situation and the political situation in Russia. He concluded that a separate treaty between Russia and Sweden was highly unlikely and sought to convey this to his addressee. In spite of this the British government continued to view the ongoing negotiations at Åland as a threat. Beginning in May 1718, the Court of St. James repeatedly instructed Weber to find ways to disrupt Congress. The set of letters shed light on the history of Russian foreign policy at the final stage of the Great Northern War on the eve of the conclusion of the Peace of Nystad.
How could they feel good? The role of psychological needs satisfaction in the relationship between stressors and ill-being
Authors: Okros Norberth , Vîrgă Delia
Published: May 2022

Drawing on Job Demands-Resources and Self-Determination theories, this study investigates the relationship between two categories of environmental stressors (operational and organizational) and two indicators of ill-being (burnout and mental health complaints). It also studies the moderating role of psychological needs satisfaction in this relationship. The results showed that environmental stressors are positively related to burnout and mental health complaints in a sample of 345 Romanian correctional officers. Also, high needs for autonomy and relatedness moderated the relationship between stressors and ill-being. Satisfaction of the need for competence, in turn, did not moderate this relationship. This research demonstrates the essential role that satisfying psychological needs plays for the correctional officers' ill-being. The buffering roles of satisfaction of the needs for autonomy and relatedness in the stressor-strain relationship elicits a better understanding of the psychological resources that help maintain low levels of burnout and mental health complaints.
Interventions for the prevention of perceived unfairness in assessment contexts
Authors: Butucescu Andreea , Corbeanu Andreea , Zanfirescu Andrei Șerban , Mincu Cornel Laurențiu , Vîrgă Delia , Iliescu Dragos
Published: May 2022

Based on a posttest-only control group design, we analyzed the efficiency of three group-level interventions (i.e., cognitive reframing, mood induction, and instrumental interventions) on the fairness perceptions of 198 participants in an assessment context. Each intervention was derived from a conceptual framework (Gilliland’s theory, Cognitive-Behavioural Therapy, Affect-as-Information Perspective), which was empirically validated. Although the results are not extremely encouraging, as between the three experimental groups and the control one (no intervention) there were not large statistical differences, our study still highlights that the assessors need to focus on the participants if they wish to increase their perceptions of fairness, not only over its formal elements. A series of limitations and future research directions are presented.
Proactive strategies in work environments - precursors or outcomes of well-being and performance?
Authors: Vîrgă Delia
Published: May 2022

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Determination of the extraction frequency of green tea leaves by the antioxidant method
Authors: Maslov Oleksandr Yu. , Komisarenko Mykola A. , Kolisnyk Serhii V. , Golik Mykola Yu. , Tsapko Yevhen O. , Akhmedov Elshan Yu.
Published: May 2022

Aim. To determine the optimal extraction frequency of green tea leaves with 60 % ethanol by the antioxidant method.Materials and methods. Chun Myn green tea leaves were the object of the study, the raw material was collected in Anhui province (China) from March to April. Dry green tea leaves were standardized according to the European Pharmacopeia 9.0. Spectrophotometry was used to quantify biologically active substances. The antioxidant activity was determined by the potentiometric method. Potentiometric measurements were performed on a HANNA 2550 pH meter (Germany) with a combined platinum EZDO 50 PO electrode (Taiwan). A UV-1000 spectrophotometer (China) was used to measure the optical density.Results and discussion. The total content of phenolic compounds was 9.60 ± 0.17, 1.30 ± 0.03 and 0.12 ± 0.002 %, catechins – 9.20 ± 0.18, 1.20 ± 0.02 and 0.07 ± 0.002 %, flavonoids – 0.27 ± 0.005, 0.04 ± 0.001, 0.005 ± 0.001, hydroxycinnamic acids – 0.49 ± 0.01, 0.07 ± 0.002 and 0.007 ± 0.001 %, dry residue – 10.75 ± 0.11, 1.59 ± 0.02 and 0.15 ± 0.002 %, the antioxidant activity was 474.08 ± 9.48, 67.70 ± 1.35 and 7.01 ± 0.14 mmol-equiv mdry res-1 for the first, second and third extraction, respectively. According to the results obtained, the optimal number of extractions of the raw material with 60 % ethanol was found to be two.Conclusions. The dynamic of extractions of biologically active substances of green tea leaves has been studied by triple extraction of the raw material to find the optimal extraction frequency; for the first time, a method for determining the extraction frequency based on the antioxidant activity of the extracts has been developed and proposed. It has been found that the optimal extraction rate is 2 times. The results obtained will be used in the further production of herbal medicines, dietary supplements, and cosmetic products with a green tea extract.
Application of the enzymatic method for the quantitative determination of dequalinium chloride in lozenges
Authors: Blazheyevskіy Mykola Ye. , Koval’ska Olena V.
Published: May 2022

Aim. To develop a new kinetic spectrophotometric enzymatic method suitable for the quantitative determination of dequalinium chloride in lozenges.Materials and methods. An enzymatic kinetic spectrophotometric method for the quantitative determination of dequalinium chloride in lozenges  has been proposed. It is based on the ability of dequalinium chloride to inhibit the enzymatic hydrolysis reaction of acetylcholine by cholinesterase in the presence of the acetylcholine (AСh) excess and H2O2. The degree of inhibition was determined by the kinetic method using two conjugated reactions: ACh perhydrolysis (interaction with an excess of hydrogen peroxide) followed by oxidation with the peroxyacid formed. Peracetic acid formed in situ by the reaction between unreacted ACh and H2O2 interacts with p-phenetidine forming a product, which absorbs at λmax = 354 nm, in the phosphate buffer solution with pH 8.3 at room temperature.Results and discussion. The linear dependence of the calibration graph for the quantitative determination of dequalinium chloride was in the concentration range of 0.2 – 0.8 μg mL–1 (r = 0.999). LOD and LOQ were 0.01 × 10–6 and 0.03 × 10–6 mol L–1, respectively. For the quantitative determination of dequalinium chloride in lozenges, RSD ≤ 2.65 % (accuracy, δ = -1.10…+1.78 %).Conclusions. A new enzymatic kinetic spectrophotometric method has been developed, and its applicability to the quantitative determination of dequalinium chloride in lozenges has been shown. It does not require a complicated treatment of the analyte and a tedious extraction procedure. The method proposed is sensitive enough to determine a small amount of the active pharmaceutical ingredient. These advantages encourage the application of the method proposed in routine quality control of the drugs studied in analytical laboratories.
The quantitative determination of glutathione by the effect of the chemiluminescence inhibition in the catalytic oxidation reaction of luminol with hydrogen peroxide in the presence of hemoglobin
Authors: Blazheyevskіy Mykola Ye. , Bondarenko Nataliia Yu. , Mozgova Olena O.
Published: May 2022

Aim. To develop a method for the quantitative determination of reduced glutathione in a lyophilized powder for the preparation of “Hepaval®” solution for intravenous and intramuscular administration by the effect of inhibiting chemiluminescence in the luminol (H2L)–Н2О2–hemoglobin (Hb) system.Materials and methods. The study object was the reduced glutathione substance and lyophilized powder for the preparation of “Hepaval®” solution for injection, ampoules of 4 mL No. 10 manufactured by “Valartin pharma” (Italy). The glutathione content in powder was determined using the chemiluminescence method by the effect of inhibiting the luminol oxidation reaction with hydrogen peroxide in the presence of Hb as a catalyst. The analysis was performed by the standard addition method.Results and discussion. As a result of the studies, it has been found that under optimal conditions glutathione shows a noticeable inhibitory effect on chemiluminescence in the H2L–H2O2–Hb system. This phenomenon was used to develop a new procedure for the quantitative determination of glutathione in the substance and lyophilized powder for the preparation of “Hepaval®” aqueous solution for injection. The linear dependence of the integral chemiluminescence intencity (S) on the molar concentration of glutathione was maintained in the concentration range of (2 – 20) × 10–7 mol L-1. The graph equation was S = (–1.6 ± 0.2) × 107 × c + (198.9 ± 2.0), (r = 0.999). The relative standard deviation (RSD) was ±1.82 % (n = 7, P = 0.95). Conclusions. The method has been developed, and the possibility of the quantitative determination of glutathione in powder for the preparation of “Hepaval®” solution for injection by the method of the chemiluminescence inhibition of the H2L–Н2О2–Нb system has been shown. The content of glutathione in powder calculated with reference to dried substance was 91.49 % (against 90.8 % by the certificate). The accuracy was +0.76 %.
The results of grouping of the Ukrainian regions by epidemiological indicators for lung and bronchial cancer as an important component in the development of rational ways to finance the pharmaceutical component of state programs to combat cancer
Authors: Panfilova H. L. , Pulnyi Yu. Yu. , Tereshchenko L. V. , Chernukha V. M. , Iurchenko G. M.
Published: May 2022

Aim. To group the regions of Ukraine by the indicators of morbidity and mortality of the population from lung and bronchial cancer and identify the areas that require public attention and resource support from the state for the purpose of early detection of these pathologies and the organization of effective pharmaceutical provision of cancer patients.

Materials and methods. The data of the National Cancer Register for 2014-2019 by indicators of morbidity and mortality of the population from lung and bronchial cancer were analyzed. Both general theoretical (historical, analytical-comparative, system, graphical, logical, hypothetical-deductive) and applied (epidemiological, mathematical-statistical) research methods were used.

Results. It was found that the average values of morbidity and mortality of the population from lung and bronchial cancer in Ukraine in accordance with the sex and age structure were 66.78 ± 0.05 and 53.67 ± 0.03 per 100 thousand populations, respectively. There was a significant fluctuation in these indicators by regions. The lowest and highest values of morbidity and mortality were observed in the same regions, namely in Kyiv and the Kherson region, respectively. Thus, in the Kherson region, the average incidence of lung and bronchial cancer was 1.8 times, and the death rate was 1.9 times higher than in Kyiv. It was proven that most regions (45.84 % of their total number) of the country were included in the groups with an unfavorable (3 regions and Ukraine as a whole) and extremely unfavorable state of development of the oncoepidemiological situation (7 regions of the country). Concern about the high mortality rate from lung and bronchial cancer is caused by the situation that has developed in the Kharkiv, Khmelnytskyi and Mykolaiv regions. We believe that in the group of regions with an extremely unfavorable state of development of the oncoepidemiological situation for lung and bronchial cancer, special attention in the direction of early detection and effective medical and pharmaceutical support should be paid to areas with the highest rates of morbidity and mortality of patients. These are Dnipropetrovsk, Zaporizhia, Kirovohrad and Kherson regions.

Conclusions. The presence of significant fluctuations in morbidity and mortality rates of the population from lung and bronchial cancer in the regions of the country necessitates the development and implementation of regional programs for the early detection of these pathologies and the provision of cancer patients with affordable and effective anticancer drugs in accordance with the existing resource provision at the regional and local community level.
The study of modern trends in the development of digital logistics in the pharmaceutical industry
Authors: Lisna A. G. , Posilkina O. V. , Litvinova O. V. , Bratіshko Yu. S.
Published: May 2022

Aim. To analyze the current trends in the field of digitalization of pharmaceutical logistics and supply chain management in the context of the coronavirus pandemic and identify factors that hinder the introduction of digital technologies into the activities of pharmaceutical market entities.

Materials and methods. To achieve the goal of the study, an analysis of foreign and domestic scientific literature, an expert survey of managers and employees of pharmaceutical companies was conducted. The research methods were abstract-logical, monographic, system and content analysis, expert survey.

Results. The relevance of digitalization of pharmaceutical logistics and supply chain management in the context of the coronavirus pandemic has been substantiated. A review of the practice of implementing digital technologies in the activities of domestic pharmaceutical companies has been conducted. According to the expert survey, the problems of introducing digital technologies into the activities of pharmaceutical companies from the point of view of managers and the staff have been identified. The reasons that hinder the process of introducing modern digital technologies into the activities of the domestic pharmaceutical sector in the field of healthcare have been determined.

Conclusions. The use of digital technologies is a necessary element of restructuring the information and logistics support for all participants in pharmaceutical supply chains, improving the reliability and quality of their activities and protecting the chains from counterfeit products. This problem is especially relevant in a pandemic when a well-organized and uninterrupted pharmaceutical logistics becomes in many cases an important condition for preserving not only health, but also human life. Therefore, today it is necessary to implement a comprehensive system of measures aimed at increasing the level of digitalization of the pharmaceutical industry, which will contribute to increasing the efficiency of the functioning of pharmaceutical supply chains, as well as improving the reliability and continuity of drug supply to the population of Ukraine.
The marketing analysis of paracetamol and ibuprofen for the treatment of acute respiratory infections in Ukraine
Authors: Balitska О. P. , Zlahoda V. S. , Hryhoruk Yu. M. , Polischuk Yu. M. , Haiday О. D.
Published: May 2022

Aim. To conduct the marketing analysis of medicines registered in Ukraine with the international nonproprietary name (INN) – ibuprofen and paracetamol for the treatment of acute respiratory infections (ARI).

Materials and methods. The data of the State Register of Medicines of Ukraine, the data of the Register of wholesale and selling prices for medicines in Ukraine as of March 2021 were used. Bibliosemantic, marketing, analytical, graphic, frequency and descriptive analyses were applied.

Results. The marketing analysis of ibuprofen and paracetamol revealed their different drug forms, namely children’s forms were presented in the form of suspensions, syrups, suppositories, while adults forms – in the form of tablets, capsules, sachets, injectable dosage forms. It was found that ibuprofen was represented at the pharmaceutical market of Ukraine by 10 trade names (TN) in the form of tablets, 5 TN in the form of capsules. 7 TN of Paracetamol were presented in the form of a solution for injection at the pharmaceutical market of Ukraine, 10 TN were in the form of tablets, and 2 TN were in the form of suppositories. The cost of ibuprofen and paracetamol was studied: the cost of 1 package of children’s medicines ranged from 17.2 to 102.31 UAH, ibuprofen – from 16.2 to 150 UAH, paracetamol – from 15.09 to 980 UAH. The most expensive paracetamol was represented by the trade name Parafusiv (paracetamol, 10 mg/ml for inf., 100 ml vial, 10 mg/ml, No.10 (Portugal)).

Conclusions. The marketing research of ibuprofen and paracetamol has shown their diversity at the pharmaceutical market of Ukraine. These drugs are represented by a wide range of trade names, drug forms, manufacturers and a wide range of prices. The country-manufacturer of all drugs presented is Ukraine (73 %).
The study of the effect of adherence with modern recommendations on antihypertensive therapy on compliance of patients with arterial hypertension
Authors: Kireyev I. V. , Zhabotynska N. V.
Published: May 2022

Aim. To study the relationship between the adherence with modern recommendations on antihypertensive therapy using fixed combinations of drugs in a “single” tablet with patients’ compliance and suggest ways to improve compliance in patients with hypertension based on the data obtained. 

Materials and methods. Compliance of patients was assessed using the compliance scale of Hill-Bone arterial hypertension therapy; the nature of the antihypertensive therapy received was analyzed.

Results. Compliance of hypertensive patients was 63.64 %. No patients with low compliance and no compliance at all were found among the patients examined. Female patients had 1.32 times more compliance for treating hypertension than male patients. At the same time, only 36.11 % of patients received a fixed combination of drugs in a “single” tablet. It was found that in patients receiving monotherapy with an antihypertensive drug, compliance was 60 %; in patients receiving combination therapy with several drugs compliance was 68.75 %, while compliance of patients receiving fixed combinations of antihypertensives was 71.43 %.

Conclusions. The results obtained indicate a relatively low level of compliance in patients with hypertension. Also, against the background of insufficient adherence with current recommendations on antihypertensive therapy, a significantly higher compliance of patients treated with fixed combinations of antihypertensive drugs in a “single” tablet has been determined.
SUBSIDIARIEDAD Y SOBERANÍA DE LAS ESFERAS: LAS CONCEPCIONES CATÓLICA Y REFORMADA DEL PAPEL DEL ESTADO
Authors: Chaplin Jonathan
Published: May 2022

Traducción de Adolfo García de la Sienra
LA ESTRUCTURA DE LA TEORÍA EMPÍRICA Y EL REDUCCIONISMO
Authors: Meier Thomas
Published: May 2022

En este trabajo expondré la temática del reduccionismo dentro del campo de la filosofía de la ciencia. Para ello, abordaré primero la posición reduccionista clásica del positivismo lógico. Luego, discutiré de qué manera debemos aproximarnos al intento de representar formalmente las reducciones teóricas que de facto se pueden llevar a cabo entre teorías científica o de partes de ellas. Para ello, argumento, es indispensable hacer uso de un marco conceptual que hace uso de la lógica matemática y de sus herramientas. En una tercera parte discutiré si la posición de Ladyman, Ross, et. al. (2007) sobre el reduccionismo presenta una vía prometedora para posicionarse en el debate.
LEY Y SINDÉRESIS EN SANTO TOMÁS DE AQUINO
Authors: Morandín Ahuerma Fabio
Published: May 2022

En este artículo se plantean algunas consideraciones clásicas que Santo Tomás de Aquino formuló sobre la fundamentación de la ley como producto de la razón y su relación con las leyes de los hombres. Se analiza el papel de la sindéresis como vínculo del individuo con la ius naturae y se concluye que la vida buena tiene un referente en el "estado de derecho" y en la práctica de las virtudes morales.
MENTALIDAD HISPANOAMERICANA: SAMUEL RAMOS ANTE LA CONSTRUCCIÓN DEL CONCEPTO SITUADO DE HOMBRE
Authors: Morandín Fabio
Published: May 2022

El tema principal de este trabajo es rescatar la propuesta de Samuel Ramos para una antropología filosófica desde su nuevo humanismo. Se analizan dos problemas principales: la dicotomía mundo material-espiritual; y el sentido de complejidad que redimensiona al hombre como un ser ideal o identitario en respuesta a la pregunta kantiana: Was ist der Mensch?
Vida humana y vocación
Authors: Lasaga Medina José
Published: May 2022

Si comprendemos el núcleo del proyecto teórico de Ortega como el intento de pensar una filosofía más allá del idealismo, tendrá su experimentum crucis en el éxito o el fracaso a la hora de descubrir, más allá del yo-conciencia o subjetividad, una forma del yo que, sin negar la evidencia de que se da en primera instancia como conciencia de sí, descubra por detrás de esa constitución inicial, una realidad más compleja. Como ingrediente de la vida humana, en articulación con el mundo, es el yo un proyecto o programa de vida libre que se revela como vocación. Se trata de que nuestra vida, que “se nos da sin hacer”, debe, o mejor, tiene que adquirir una determinada figura de existencia. El imperativo de Píndaro, que preside la ética de Ortega, “llega a ser el que eres”, encierra ese mandato de ejecutar en la circunstancia la llamada que nos cursa nuestro destino, de dar vida al “personaje” ideal que cada cual lleva dentro.
Alcances de un concepto difuso: ¿Qué es y cómo opera la post-verdad? (Desde una perspectiva gnoseológico materialista)
Authors: Rabadán Fernández Eliseo
Published: May 2022

El asunto que analizamos implica una serie de Ideas y Conceptos- distinción esencial y de muy importante alcance para el análisis y la crítica - y un sistema para el análisis: el Materialismo Filosófico y una Teoría de las ciencias (Teoría del Cierre Categorial). Implica que entendemos que la Filosofía es por sí misma dialéctica, polémica, se hace siempre frente a otras alternativas, opuestas desde diversos puntos de análisis que inevitablemente se enfrentan, tanto a nivel de Filosofía mundana, como de la Académica.
La libertad: un método de unidad social en el concepto de Verdad
Authors: Zuluaga Salazar Sebastián
Published: May 2022

Este artículo se interesa en demostrar la necesidad que existe de llevar la libertad como fuente mediadora de las transciciones que existen en el sujeto y la unidad social como fundamento que subyace en el concepto de Verdad en los sistemas de Hegel y Pavel Florenski. Para ello, primero  se expone la confrontacion entre la libertad y la voluntad, que juegan un papel fundamental para la formacion sistemática de la contemplación de Dios como trinidad, que logra superar los rasgos finitos e infinitos del indviduo. Segundo, demostrar como a través de la libertad se llega a la unidad, porque la sociedad ha elevado su espiritu a través de determinaciones que establecen una autoconciencia y crecen socialmente para alcanzar la unidad en la Verdad. Por último, se presentará las consideraciones finales de la libertad.
The Community Empowerment in Kelapa Dua, Depok, through Hygiene Tempeh Production Training
Authors: Subali Dionysius , Hartanti Anastasia Tatik , Canti Meda
Published: May 2022

Many people from various communities still do not understand the value of tempeh as a healthy food item. Therefore, to improve the public knowledge about the nutritional values of tempeh, Atma Jaya Catholic University of Indonesia chose the community of Bhayangkari women from Ranting, Kelapa Dua, Depok, as the target partners in the community service program. This community, which consisted of housewives of police officers, was considered the right target because they had the role of providing healthy food for their families. In addition to providing knowledge about the importance of consuming tempeh as healthy food, the team also trained the community to produce hygienic tempeh. The activities included three stages, i.e., preparation, implementation, and monitoring and evaluation. The program preparation involved the registration of the participants, the preparation of the seminar materials, and the procurement of materials and tools for the tempeh production. Next, the implementation stage consisted of education and training activities conducted via WhatsApp (WA) and Zoom meetings. Finally, the monitoring and evaluation stage was conducted via WA to assess the tempeh production process. Through this community service program, it is evident that all the participants could be trained on how to make hygienic tempeh easily. The guidelines to produce tempeh were also easy to understand and readily available for public use. Overall, the participants became more aware of the health benefits of tempeh.
Educational Efforts to Improve Public Awareness about Greening and Healthy Lifestyle in Urban Areas
Authors: Aprillia Shereen , Budiono Jolene , Wijaya Meiliyana
Published: May 2022

Public awareness and concern about greening and healthy lifestyles in preserving the environment and improving health status are crucial despite the covid-19 pandemic. One approach to deal with this issue is by spreading the information and taking promotive actions which aim to increase public awareness of the importance of greening and healthy lifestyles in their daily lives. Various online educational activities for communities are needed to increase their knowledge and concern. In this regard, the Daerah Binaan (DABIN) unit and the Hazard Analysis and Critical Control Point (HACCP) of the Faculty of Medicine and Health Sciences at Atma Jaya Catholic University of Indonesia held a SEHATI challenge and an educational seminar "Evergreen: Go Green, Go Healthy." One of the topics raised through this online seminar was "Urban Farming in the Pandemic Period: Economical and Ecological," which discusses various benefits of growing hydroponic vegetables. In addition, the topic of promoting a healthy lifestyle includes the proper processing of fresh vegetables to avoid parasitic contamination and a healthy breakfast with the consumption of probiotics. As many as nine and 198 people attended the challenge competition and seminar. A pre-test and a post-test were held before and after the seminar to determine the participants' knowledge. The result showed that the participants' knowledge increased between 15% to 38%. The efforts to deliver periodic education about greening and healthy lifestyles action will continue to be carried out by DABIN and HACCP. These efforts aim to improve public awareness about the importance of this topic, reduce global warming, and improve the health status of an area.