bluuebunny/crossref_metadata_2025 huggingface dataset:
Arrhythmogenic left ventricular cardiomyopathy
Authors: Mirmomen Seyedeh Mojdeh , Bradley Andrew Jay , Arai Andrew Ernest , Sirajuddin Arlene
Published: October 2019

Arrhythmogenic ventricular cardiomyopathy (AVC) is a heritable heart muscle disorder characterized by fibrofatty infiltration of the myocardium. Intramyocardial fat deposition is considered arrhythmogenic and predisposes patients to life-threatening arrhythmias and sudden cardiac death. The classic subtype of AVC is characterized by fibrofatty replacement of the right ventricular myocardium (i.e. arrhythmogenic right ventricular cardiomyopathy). In advanced cases of arrhythmogenic right ventricular cardiomyopathy, the left ventricle may be involved as well. Predominantly left ventricular involvement by AVC is exceedingly rare and lack of specific diagnostic criteria as well as its potential cardiotoxic effect make its diagnosis challenging and of high importance.
Alterations of signaling pathways in response to chemical perturbations used to measure mRNA decay rates in yeast
Authors: Eshleman Nichole , Luo Xiangxia , Capaldi Andrew , Buchan J. Ross
Published: October 2019

Assessing variations in mRNA stability typically involves inhibiting transcription either globally or in a gene-specific manner. Alternatively, mRNA pulse-labeling strategies offer a means to calculate mRNA stability without inhibiting transcription. However, key stress-responsive cell signaling pathways, which affect mRNA stability, may themselves be perturbed by the approaches used to measure mRNA stability, leading to artifactual results. Here, we have focused on common strategies to measure mRNA half-lives in yeast and determined that commonly used transcription inhibitors thiolutin and 1,10 phenanthroline inhibit TORC1 signaling, PKC signaling, and partially activate HOG signaling. Additionally, 4-thiouracil (4tU), a uracil analog used in mRNA pulse-labeling approaches, modestly induces P-bodies, mRNA–protein granules implicated in storage and decay of nontranslating mRNA. Thiolutin also induces P-bodies, whereas phenanthroline has no effect. Doxycycline, which controls “Tet On/Tet Off” regulatable promoters, shows no impact on the above signaling pathways or P-bodies. In summary, our data argues that broad-acting transcriptional inhibitors are problematic for determining mRNA half-life, particularly if studying the impacts of the TORC1, HOG, or PKC pathway on mRNA stability. Regulatable promoter systems are a preferred approach for individual mRNA half-life studies, with 4tU labeling representing a good approach to global mRNA half-life analysis, despite modestly inducing P-bodies.
The Technology of Planning Elective Courses in Mathematics While Training Students for the Unified State Exam with the Aim of Developing Their Probabilistic Style of Thinking
Authors: Щербатых Сергей , Shcherbatykh Sergey , Лыкова Ксения , Lykova Kseniya
Published: October 2019

In today’s rapidly changing socio-economic conditions, people often have to face the problems, the solution of which is non-standard. A potentially possible means of the creative problem solving is a probabilistic style of thinking, which implies a departure from stereotypes. It is often connected with a refusal to act according to strictly determined rules, and a deviation of the negative attitude to the randomness of many phenomena and processes of the world. The order is born out of chaos as a result of self-organization. The article proposes a solution to the problem of achieving the quality and productivity of education through the development of schoolchildren’s probabilistic thinking style while training them for the Unifi ed State Examination in mathematics of the profi le level. A substantial component of the elective course “Probabilistic nature of mathematical problems of the Unifi ed State Exam” in mathematics in the system of general education is proposed. A group of tasks is presented which are done with the use of operations: the analysis and synthesis, combination, transposition, evaluation. The actualization of the components of the probabilistic style of thinking is aimed at improving the effi ciency of the learning process, improving the entire holistic system of development and self-development of the student’s personality. The main task of the informative fi lling of the elective course in mathematics in general education is to form a unifi ed scientifi c picture of the world in students, to develop a new culture of thinking, to identify interdisciplinary connections and to combine diff erent activities in the learning process. The reported study was funded by RFBR according to the research project № 18-313-20002 “Theoretical and methodical ensuring the fractal formation and development of the probabilistic style of thinking in the conditions of global informatization of education (on the example of teaching mathematics)”.
Training in the System of Further Vocational Teacher Education
Authors: Кашицына Ю. , Kashicyna Yu. , Гурулева Т. , Guruleva T.
Published: October 2019

The article discusses some aspects of improving the system of continuing education of teachers. The importance of the methods of active learning and interactive technologies in the formation of communicative, psychological and pedagogical competencies of teachers is shown. Particular attention is paid to socio-psychological training. The training learning process is described. The article is addressed to teachers and teachers, students of pedagogical universities, methodologists, directors of educational organizations.
DIÁLOGOS ENTRE MUSEU E ESCOLA: RELAÇÕES POSSÍVEIS NO CENÁRIO DE PESQUISA ATUAL.
Authors: Cagliari Angela Zanotelli , Zucolotto Andréia Modrzejewski
Published: October 2019

Este estudo tem como objetivo conhecer e analisar artigos científicos que discorrem sobre as relações entre museu e escola. O presente texto trata-se de uma revisão bibliográfica baseada na literatura especializada recente, dentro do período temporal de 2007a 2017, na qual procurou-se identificar, descrever e analisar as produções científicas em formato de artigo mais atuais disponíveis em língua portuguesa. Os artigos analisados buscam interlocuções teóricas e práticas entre museu e escola, a partir de diferentes vieses. Esta revisão mirou publicações que articulassem o espaço museológico e o espaço escolar na expectativa de desvendar o atual contexto de investigação científica relativo à educação formal e seus possíveis diálogos com a museologia. Conclui-se que ainda há poucos estudos realizados na área e o principal foco das pesquisas abordadas está no museu enquanto locus social, logo educativo. Destaca-se a importância de realizar outras investigações em idioma português sobre o tema a fim de colaborar para o desenvolvimento da área de museologia associada à educação.
UMA PROPOSTA DE ENSINO A PARTIR DA HISTÓRIA DA FÍSICA
Authors: Pereira Nádia Vilela , Araújo Mauro Sérgio Teixeira de
Published: October 2019

A História da Física é um recurso capaz de contribuir para tornar o ensino de Física mais crítico, revelando uma preocupação em favorecer um melhor entendimento da realidade. Conhecer a História da Física, o seu desenvolvimento e o processo de aceitação e consolidação de teorias científicas podem ajudar a frisar a não linearidade do desenvolvimento dos conhecimentos da Física e as diferentes leituras que dela podemos ter. Ao longo de vinte aulas envolvendo três turmas do 3º ano do Ensino Médio Integrado (EMI), do IFTO - Campus Palmas, utilizamos uma estratégia didática fundamentada em cinco eixos: apresentação de filme, apresentação de PowerPoint, leitura e discussão de textos históricos, um experimento simples baseado na construção de um eletroscópio de folhas e uma atividade avaliativa escrita. Os resultados obtidos mostraram que houve uma evolução na aprendizagem dos conceitos físicos e também uma maior motivação por parte dos alunos durante as aulas, permitindo salientar a relevância de se abordar a Física contextualizada em sua História e a importância da História da Física para os processos de ensino e aprendizagem.
CAROLINA: MARIAS QUE NÃO SE CALAM
Authors: Muniz Ana Guimarães Corrêa Ramos , Soares Alexsandro Rosa , Callai Cristiana
Published: October 2019

Neste artigo contextualizamos a vida e as obras de Carolina Maria de Jesus, bem como cortejamos as suas palavras encharcadas do cotidiano vivido, inscritas no livro Quarto de Despejo: diário de uma favelada, publicado em 1960. Carolina é uma personalidade feminina importante da Literatura Brasileira por se contrapor aos arquétipos estabelecidos pelo âmbito social, em relação às personalidades literárias tidas como canônicas. A obra foi inspiração para que alunos do Ensino Médio, impactados pela vida de Carolina, traçassem suas histórias em escritas.
PERCEPÇÕES DA EQUIPE TÉCNICA ESCOLAR E DAS FAMÍLIAS DOS EDUCANDOS NUMA ESCOLA DE REFERÊNCIA DO RIO DE JANEIRO SOBRE BULLYING E O PAPEL DA ORIENTAÇÃO EDUCACIONAL
Authors: Martins Ana Carolina Hyer de Faria da Silva , Barreiros Cláudia Hernandez
Published: October 2019

Este artigo foi construído a partir da pesquisa de mestrado que resultou na elaboração da dissertação intitulada “‘Nem sempre o adulto resolve’: o serviço de orientação educacional e as práticas de bullying no primeiro segmento do ensino fundamental.”.  O recorte elaborado destaca 1) as percepções da equipe escolar e dos responsáveis de educandos sobre o bullying em uma escola de referência do Rio de Janeiro; 2) o papel da orientação educacional e da equipe escolar nas práticas de prevenção e enfrentamento do bullying. Por meio de uma pesquisa qualitativa na qual foram utilizados, como instrumentos de coleta de dados, a entrevista semi-estruturada e a sondagem de opinião, foi possível analisar as formas de bullying presentes na instituição, sua relação com o preconceito e as práticas pedagógicas/ funções de cada agente participante da pesquisa no processo de manutenção, prevenção e enfrentamento do bullying.
EFFECTS OF IGNEOUS INTRUSION ON THE MINERALOGICAL CONTENT OF IRATI FORMATION, PARANÁ BASIN, IN SAPOPEMA (PR), SOUTHERN BRAZIL
Authors: Holanda Werlem , Costa dos Santos Anderson , Nogueira Camila Cardoso , Bertolino Luiz Carlos , Bergamaschi Sérgio , Rodrigues René , Felipe da Costa Diego
Published: October 2019

Igneous intrusions in sedimentary basins are commonly related with mineralogical association changes in host-rock. At Sapopema region (Paraná State, southern Brazil), an extensive diabase sill (associated to Serra Geral Formation) was emplaced in pelitic-carbonate succession during post-Triassic. The sedimentary host-rock association includes mostly shale, siltstone and carbonate of the Permian Irati Formation. X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) data revealed that heat transfer was not enough to cause modifications in mineral assemblage of the Taquaral Member (quartz + albite + muscovite + illite + kaolinite + chlorite). However, mineralogical content from Assistência Member presented changes probably caused by the intrusion of diabase sill (talc + pyrophyllite + calcite). Talc and calcite were formed due to the reaction between dolomite and quartz, while pyrophyllite was the product of reaction between kaolinite and quartz. EFEITOS DA INTRUSÃO IGNEA NA COMPOSIÇÃO MINERALÓGICA DA FORMAÇÃO IRATI, BACIA DO PARANÁ, SAPOPEMA (PR), SUL DO BRASIL ResumoAs intrusões ígneas em bacias sedimentares dão origem em geral a alterações mineralógicas da rocha hospedeira. Na região de Sapopema (Estado do Paraná, sul do Brasil), uma extensa soleira de diabásio (associada à Formação Serra Geral) pós-Triássica, foi intrudida numa sucessão sedimentar constituída por pelitos e carbonatos. A associação de rochas sedimentares hospedeiras, era principalmente constituída por folhelho, siltito e carbonato da Formação Irati, do Permiano. Dados de difração de raios X (DRX), microscopia eletrônica de varredura (MEV) e espectroscopia de energia dispersiva (EDS) revelaram que a transferência de calor não foi suficiente para causar modificações na composição mineralógica do membro Taquaral (quartzo + albita + moscovita + ilita + caulinita + clorita). No entanto, o conteúdo mineralógico do Membro Assistência apresentou alterações, provavelmente causadas pela intrusão do diabásio (talco + pirofilita + calcita). O talco e a calcita foram formados devido à reação entre dolomita e quartzo, enquanto a pirofilita foi o produto da reação entre a caulinita e o quartzo. Palavras-chave: Bacia Sedimentar. Intrusões Ígneas. Metamorfização de sedimentos. Reações mineralógicas. XRD. SEM / EDS.
Deprescribing in end-of-life care
Authors: Gardner Emma
Published: October 2019

The aim of deprescribing in end-of-life care is to improve the patient's quality of life by reducing their drug burden. It is essential to engage the patients and enable them to make choices about medications by discussing their preferences and implement a pharmacy management plan. Withdrawing medications during the end stages of life is extremely complex because the period of care varies substantially. The aim of this article is to address polypharmacy within end-of-life care. It will review which medications should be stopped by examining the non-essential and essential drugs. The intention is to encourage an approach to care which provides an equal balance between treatment and patient expectation.
Managing sickness absence and declared disabilities in a district nursing team
Authors: Duncan Monica
Published: October 2019

Sickness absence in the NHS is around 2.3% higher than in the rest of the economy. Although policies and guidelines are in place to manage this problem, stress-related illness is on the rise. Managing sickness, absence and declared disabilities in district nursing teams is an issue that must be handled by staff members, team managers and the wider organisation. Occupational health services are a crucial component in both preventing and managing staff sickness and absence, but these may well not have adequate resources to cope with increased stress-related illness. Ensuring that occupational health services are adequately resourced and able to respond appropriately to both the needs of staff in need of their support and managers is part of the organisational responsibilty. This article aims to guide managers in caring for their staff properly and meeting service demand, a difficult balancing act.
ReadyWrap®: case studies in practice
Authors: Schofield Alison
Published: October 2019

The cost that chronic wound care imposes on both patients and health services worldwide is well recognised. Most patients with venous leg ulcers require compression therapy over the long term, for both treatment as well as to prevent recurrence of these wounds. Caring for patients with chronic wounds makes up a large part of the workload for district and community nurses, and encouraging self-management among patients is a worthwhile effort to limit the costs and resources directed for this purpose. The present article describes the practical use of the ReadyWrap range of compression garments, which are available in various different styles, and aid patients, their families and carers in the self-management of venous leg ulcers. These products are designed with their long-term use in mind, and, as described in the case studies in this article, patients show good concordance to compression therapy involving ReadyWrap.
Bone Health in Relation to Vitamin-D Status and Serum Adipokines in Obese Egyptian Children
Authors: A. El Wakeel Maged , A. Shehata Manal , M. El-Kassas Ghada , H. Mostafa Hend , M. Galal Essam , Refat El-Zayat Salwa , Abd EL Ghaffar Mohammed3 Nagwa
Published: October 2019

Childhood obesity has been linked to an increase in fracture risk, so the impact of obesity on bone metabolism is becoming a focus of attention to identify factors that may affect bone health in obese children. Therefore, this study aimed to examine the association between serum 25-Hydroxy vitamin D [25(OH) D], adipokines and bone status in obese children. This case control study was executed in the Child Health Clinic in Medical and Scientific Centre of Excellence, National Research Centre (NRC), 100 obese and 80 non-obese age- and sex-matched children were enrolled in our study with mean age of (10.12±2.34 & 9.62±1.67 years) respectively. Anthropometric measurements, femoral neck bone mineral density (BMD) and its Z-score, bone mineral content (BMC) were measured using dual-energy X-ray absorptiometry (DXA) in relation to body weight (kg), we also determined serum 25(OH) D, adiponectin, leptin and lipid profile. HOMA-IR was calculated to assess insulin resistance. It was found that BMC and BMD Z-score adjusted for weight were significantly lower in obese children as compared to controls (all p<0.05). Obese children had lower levels of 25(OH) D and adiponectin (P<0.01), while higher levels of leptin, total cholesterol (TC) and triglycerides (TG) compared to controls (P<0.01). Both BMC and BMD Z-score showed positive association with 25(OH) D and adiponectin (P<0.01) and negative association with HOMA-IR, TG and TC (P<0.05). Linear regression analysis showed that 25(OH) D was the most effective factor predicting BMD Z-score and BMC in obese children. It is concluded that, obesity is negatively related to bone health in childhood. Those obese children are at increased risk for vitamin D insufficiency, which shows an obvious relationship to lower bone mass, raising the question of supplementation to prevent the deleterious effect of its deficiency on bones and reducing future risk of fracture and osteoporosis.
Comparative Study on the Efficacy of Losartan and Amlodipine in Reducing Microalbuminuria in Patients with Primary Hypertension, a Randomized open Label Parallel Group Study
Authors: P Sowmya , c Balaji , Amutha Elizabeth Arul , Punnagai Punnagai
Published: October 2019

Majority of the cardiovascular and renal diseases has been associated with Hypertension Primary hypertension also called as essential or idiopathic hypertension tends to be familial and the prevalence increases with age. Microalbuminuria has been correlated with microvascular damage in hypertension patients.To Compare the Efficacy of Losartan and Amlodipine in reducing microalbuminuria in patients with primary hypertension.An open labeled parellel group cross sectioned study was conducted in Sree Balaji medical college and hospital, Department of General Medicine Chrompet during the period of March 2015 to December 2015. In our research study suggested that there are major differences between Angiotensin receptor blockers and calcium chaneel blockers in reducing microalbuminuria in essential hypertension. After 6-month of losartan treatment, the reduction in urine albumin level is statistically highly significant (p<0.01) 71.17±66.04**. compared with baseline101.95±94.70. After 6 months of Amlodipine treatment group resulted in statistically not significant (p>0.05) in urine albumin excretion level 99.85±96.35 compared with baseline 101.11±95.28 in essential hypertensive patients .Hence this study shows that losartan after administration for 6 months ,conferred significant advantages over amlodipine in terms of reduction of urinary albumin levels levels in hypertension patients
Ratio of coral reefs to macroalgae: An ecosystem approach management
Authors: Ahmad Aditiyawan , Fahrudin Achmad , Boer Mennofatria , Wardiatno Yusli , Kamal Mohammad Mukhlis
Published: October 2019

Abstract. The decline in the quality of coral reef ecosystems is not only caused by human activities but also caused by competition in ecosystems, including competition for space and nutrients. Research on the comparison of coral reefs with macroalgae is one of the determinants of coral reef health which is the basis for the management of coral reefs with an ecosystem approach. The purpose of this study was to analyze the comparison of coral reef cover with macroalgae. The research method used is Line Intercept Transect (LIT), the research location is 13 stations divided into 3 locations, namely north, centre, and south from Ternate Island in North Maluku. The results showed that the condition of coral reefs ranged from 24 – 86.60%, based on the condition categories of 13 observation locations, the coral reefs of Ternate Island were in very good condition at 15.38%, good conditions at 46.16%, adequate conditions at 30.77%, and damaged conditions 7.69%, while the condition of macroalgae cover ranged from 0 - 30.60% in the area of coral reef ecosystems. The ratio of the of coral reefs to algae ranges from 0 to 1.117, based on the ratio value, it is classified as low, medium to high, spread in the coral reef ecosystem of Ternate Island. Coral reef management strategies on Ternate Island include a continuous monitoring program for coral reef ecosystems, education on coral reef ecosystems, creating a conscious community of waste, and limiting the capture and restoking of herbivorous fish in coral reef areas.Keywords: Coral reef, ecosystem approach management, macroalgae, Ternate Island
Recombinant adenoviral vaccine encoding the spike 1 subunit of the Middle East Respiratory Syndrome Coronavirus elicits strong humoral and cellular immune responses in mice
Authors: Ababneh Mustafa , Alrwashdeh Mu'men , Khalifeh Mohammad
Published: October 2019

Background and Aim: Middle East respiratory syndrome coronavirus (MERS-CoV) has rapidly spread throughout the Middle East since its discovery in 2012. The virus poses a significant global public health threat with potentially devastating effects. In this study, a recombinant adenoviral-based vaccine encoding the spike 1 (S1) subunit of the MERS-CoV genome was constructed, and its humoral, and cellular immune responses were evaluated in mice.

Materials and Methods: Mice were immunized initially by intramuscular injection and boosted 3 weeks later by intranasal application. Expression of the S1 protein in the lungs and kidneys was detected using conventional polymerase chain reaction (PCR) and immunohistochemistry (IHC) targeting specific regions within the S1 subunit at weeks 3, 4, 5, and 6 after the first vaccination. Antigen-specific humoral and cellular immune responses were evaluated in serum and in cell culture following in vitro stimulation with a specific 9-mer epitope within the S1 protein (CYSSLILDY).

Results: S1 protein expression was only detected by IHC in the kidneys of the Ad-MERS-S1 group at week 6 from first immunization, and in both lungs and kidneys of Ad-MERS-S1 group by conventional PCR at weeks 3 and 5 post-prime. The vaccine elicited a specific S1-immunoglobulin G antibody response, which was detected in the sera of the vaccinated mice at weeks 4 and 6 from the onset of the first immunization. There was a significant increase in the amount of Th1-related cytokines (interferon-γ and interleukin [IL] 12), and a significant decrease in the Th2-related cytokine IL-4 in splenocyte cell culture of the vaccinated group compared with the control groups.

Conclusion: The results of this study suggest that this recombinant adenovirus vaccine encoding the S1 subunit of MERS-CoV elicits potentially protective antigen-specific humoral and cellular immune responses in mice. This study demonstrates a promising vaccine for the control and/or prevention of MERS-CoV infection in humans.
Vidéki egyetemek harmadik missziós tevékenysége: a társadalmi tudásmegosztás hatásai
Authors: Sitku Krisztina
Published: October 2019

Tanulmányomban a doktori kutatási témámhoz legközvetlenebbül kapcsolódó felsőoktatáskutatási fogalmak és jelenségek összefoglaló bemutatására vállalkozok az általam eddig megismert hazai szakirodalom alapján. Ebben a magyarországi vidéki egyetemek helyi-regionális közösségi elköteleződése jegyében indított harmadik missziós tevékenységeinek céljait, megvalósításuk módját, eredményeit és nehézségeit, valamint az érdekhordozókra kiváltott hatásait kívánom majd megvizsgálni néhány kiválasztott intézmény és cél, különös tekintettel a hallgatói létszámnövelés tekintetében. Ezért tanulmányomban ismertetem a harmadik misszió fogalmát, stratégiai fontosságúvá válásának okait és változatos céljait, a működési keretét nyújtó négyes- és ötös spiráll modelljeit, valamint a vállalkozói egyetem és elkötelezett egyetem koncepcióját. A társadalmi beágyazódás fontosságának növekedése kapcsán körbejárom az egyetemi társadalmi felelősségvállalás fogalmát és megvalósításának lehetőségeit a három küldetésen keresztül, ami rávilágít arra, hogy a társadalmi elköteleződés és szerepvállalás a harmadik misszión belül, de felett is értelmezendő. Majd a gyakorlati megvalósulást példákkal is illusztrálom röviden bemutatva néhány magyarországi egyetem harmadik missziós, ill. egyetemi társadalmi felelősségvállás szellemében a közelmúltban végzett tevékenységét. Végül a harmadik misszió és a társadalmi innováció mérési lehetőségeit ismertetem a hazai szakirodalom eredményei alapján, majd felvetem a téma kutatásának nehézségeit és lehetséges további irányait. Mindez azt mutatja, hogy az egyetemek társadalmi elköteleződése stratégiailag egyre hangsúlyosabb, és egyre bővülő körű tevékenységekben realizálódik célközönségei, a helyi-regionális társadalom, ill. hallgatóik irányába. Szükséges alapjai viszont intézményesülésük, fenntarthatóságuk biztosítása, az érintettekkel való hatékony és folyamatos együttműködés, valamint az eredmények mérése. Hatásai megnyilvánulhatnak a régió gazdaságfejlődésében, társadalmi kihívásainak kezelésében, a kulturális-, sport- és tudományos élet felpezsdülésében, valamint az egyetemek regionális jellegének erősödésében és felsőoktatáspiaci súlyuk növekedésében.
La politesse que donne l'usage du monde
Authors: Gilot Christian
Published: October 2019

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Citation : Christian Gilot, "La politesse que donne l'usage du monde", lieuxdits#1, juin 2011, pp.22-23.

Bibliographie

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Entre les choses, ménager la relation
Authors: Dath Fabienne , Gorza Gildo
Published: October 2019

L’expérience forte et prégnante de la vie et du travail mené au coeur de la tradition vernaculaire du M’Zab a été déterminante, par la suite, tant dans la pratique de l’architecture que dans l’enseignement à son propos. La question qui a surgi et qui reste première dans nos esprits d’architecte et d’enseignant : comment déployer le vide entre les choses pour assurer la vie du groupe humain et des lieux à construire en relation avec leur milieu. Comment alors définir ses limites et leur matérialité de manière cohérente et mesurée.
Analyse de références architecturales en Flandres
Authors: Roose Marie-Clotilde , Ghestem Antoine , Leduc Constance
Published: October 2019

Cette publication comporte une introduction au séminaire de « Critique architecturale contemporaine » tenu par 3 enseignants avec 3 volets méthodologiques distincts. Il est suivi par les articles rédigés par 2 étudiants, Antoine Ghestem et Constance Leduc, lors des visites en Flandre pour leurs études de cas, intégrant ces 3 outils.
Du carré au cube
Authors: Claeys Damien , Raucent Marie-Christine
Published: October 2019

Cet article présente un dispositif pédagogique s’adressant aux étudiants en architecture de première année. Par l’expérimentation en maquette d’une structure en bois, l’étudiant acquière une méthode de travail empirique passant par la formulation d’hypothèses de travail, l’expérimentation directe des idées sur la maquette, une succession d’essais et d’erreurs jusqu’à la proposition d’un projet consistant.
ESTRUTURAÇÃO DE UM SERVIÇO DE INFORMAÇÕES SOBRE MEDICAMENTOS (SIM) EM UM HOSPITAL DO RIO GRANDE DO NORTE, BRAZIL
Authors: Nascimento Martins Álex Brunno , Mariz Batista Almária
Published: October 2019

Centros/Serviços de Informações sobre Medicamentos são importantes e úteis, pois contribuem para o uso racional de medicamentos. O objetivo deste estudo foi avaliar as informações prestadas pelo Serviço de Informações sobre Medicamentos do Hospital Regional Dr. Mariano Coelho em Currais Novos, RN. Para tanto, foi realizado um estudo observacional a partir do banco de dados do Serviço, cujas solicitações de informação foram recebidas entre abril de 2017 e novembro de 2018. As informações foram avaliadas a partir de média mensal de solicitações de informação, temas das perguntas, meio pelo qual foi recebida, perfil do solicitante, fontes de informação utilizadas e classificação farmacológica dos medicamentos envolvidos. Durante o período, foram recebidas 31 solicitações (1,6 solicitações/mês), a maioria tinha como tema a indicação de uso de medicamentos (22,6%) e foi solicitada pessoalmente (71,0%) por residentes multiprofissionais (45,2%). Bases de dados eletrônicas foram as fontes de informações mais utilizadas para responder às solicitações (40,0%); e os antibióticos de uso sistêmico os medicamentos mais presentes nas solicitações (23,7%). Depreende-se que este Serviço foi potencialmente útil para se evitar uso irracional de medicamentos. Em relação ao perfil de solicitações de outros centros/serviços, este apresentou perfil pouco semelhante aos demais.
A PROFISSÃO FARMACÊUTICA SOB A PERSPECTIVA DE ESTUDANTES DO ENSINO MÉDIO EM SAMAMBAIA, BRASÍLIA, DF, BRASIL
Authors: De Almeida Amanda Da Conceição , Da Silva Wallisson Luan Leoncio , Da Silva Izabel Cristina Rodrigues , Barreto Lívia Cristina Lira de Sá
Published: October 2019

Os cursos de graduação em Farmácia no Brasil permitem a inserção no mercado de um profissional com caráter generalista que domina a composição e produção dos medicamentos, alimentos e cosméticos, presta assistência farmacêutica, possui formação em análises clínicas e toxicológicas, com perfil humanista, ético, técnico e científico. Apesar da capacitação complexa e importante para a saúde, os ingressantes nos cursos de Farmácia desconhecem, na maioria das vezes, a totalidade das áreas de atuação e impactos benéficos. Dessa maneira, o presente estudo visou a aplicação de metodologia ativa para a disseminação de conhecimento acerca da profissão farmacêutica. Para tanto, o estudo foi realizado com 24 acadêmicos do ensino médio em Samambaia-DF. Um questionário foi aplicado aos voluntários antes da exposição de um material audiovisual contendo entrevistas, textos e imagens sobre a profissão farmacêutica, e um outro questionário disponibilizado após visualização. O primeiro questionário avaliou o perfil do voluntário, suas expectativas de atuação no mercado de trabalho e interesse na área da saúde. O segundo questionário estimou a apropriação de conhecimento acerca da profissão farmacêutica e interesse pela Farmácia. O estudo permitiu mensurar o desejo pela graduação em Farmácia de possíveis ingressantes no ensino superior e evidenciou o desconhecimento da importância do Farmacêutico para a saúde da comunidade.
Report on the 8th National Scientific Conference in the “Education Yesterday, Today and Tomorrow” series. Adam Mickiewicz University in Poznań, 24 May 2018
Authors: Klimek Daria
Published: October 2019

Sprawozdanie
Two new letters from Michael Boym, SJ in Europe (1656; 1658), and the editorial dossier of his various European works on China
Authors: Golvers Noël
Published: October 2019

Golvers Noël, Two new letters from Michael Boym, SJ in Europe (1656; 1658), and the editorial dossier of his various European works on China (Dwa listy Michała Boyma SJ do Europy (1656; 1658) i edytorskie dossier jego rozmaitych prac powstałych w Europie na temat Chin).Both items, now in Munich but originally from the library of Jacob Golius in The Hague, represent two so far unknown autograph letters of Michael Boym (1656; 1658). The contents reveal his initiatives to get his manuscripts (Atlas; Medicus Sinicus and a so far unknown title on moxibustion) printed. Both letters are also the first documents which shed a clear light on the network between Rome and the Amsterdam printer Blaeu, in which were involved Jacob Golius, his brother in Rome, the Carmelite Caelestinus a Sancta Lidwina, and the Antwerp hagiographers Bollandus and Henschenius; this was the same network as the one behind the printing process of Martini’s Novus Atlas Sinensis.
Controlling a motorized electric wheelchair based on face tilting
Authors: Qassim Hassan M. , Eesee Abdulrahman K. , Osman Omar T. , Jarjees Mohammed S.
Published: October 2019

Disability, specifically impaired upper and/or lower limbs, has a direct impact on the patients’ quality of life. Nowadays, motorized wheelchairs supported by a mobility-aided technique have been devised to improve the quality of life of these patients by increasing their independence. This study aims to present a platform to control a motorized wheelchair based on face tilting. A real-time tracking system of face tilting using a webcam and a microcontroller circuit has been designed and implemented. The designed system is dedicated to control the movement directions of the motorized wheelchair. Four commands were adequate to perform the required movements for the motorized wheelchair (forward, right, and left, as well as stopping status). The platform showed an excellent performance regarding controlling the motorized wheelchair using face tilting, and the position of the eyes was shown as the most useful face feature to track face tilting.
Chemical characterisation of polymerised extractives in bleached birch kraft pulp
Authors: Smeds Annika I. , Vähäsalo Lari , Rahkila Jani , Eklund Patrik C. , Willför Stefan M.
Published: October 2019

The main aim of this study was to chemically characterise the polymeric fraction of birch pulp extractives. We showed that 70–96% of the material in extracts of fully bleached birch kraft elemental chlorine-free (ECF) pulp from three Finnish mills consists of compounds that are undetectable by conventional gas chromatography (GC) analysis, i.e. high-molar mass (HM) material. There were small variations in the extractive content and composition between the three mills, but the overall trend was the same. The HM material was present mainly in the acetone extracts, and the molar mass was shown to range between ca. 1000 and 10 000 Da. Alkaline hydrolysis of the hexane and acetone extracts released fatty acids (FAs) especially, but also sterols and triterpenoids. The dominating FAs were palmitic and stearic acids. Pyrolysis and thermally assisted hydrolysis and methylation (THM)-GC-mass spectrometry (MS) analyses confirmed that the HM material consists mainly of FA units, and additionally of sterol, triterpenoid and aromatic units. Nuclear magnetic resonance (NMR) analysis further confirmed the presence of FAs containing aromatic groups, but also glycerol units. The FA chains seemed to be linked to each other by ester linkages mainly, although ether linkages were also present. The FA oligomers and polymers may have a suberin-like structure.
Self-esteem and motivation with adherence of people living with HIV/AIDS (PLWHA) in Indonesia with antiretroviral therapy: a cross-sectional study
Authors: Purwaningsih Purwaningsih , Asmoro Candra Panji , Prastiwi Yenis Anggi
Published: October 2019

Introduction

Antiretroviral therapy (ART) helps reduce the amount of human immunodeficiency virus (HIV) that enters the body in order to avoid acquired immune deficiency syndrome (AIDS) and prevents the occurrence of opportunistic infections and complications. This study aims to describe the correlation between self-esteem and motivation with adherence of people living with HIV/AIDS (PLWHA) in ART.

Methods

This cross-sectional study involved 91 PLWHA who joined a non-government organization (NGO) support group, determined through a purposive sampling technique. The demography, and questionnaires about self-esteem, motivation and adherence to ART were employed to collect the raw data. The data were then analyzed using Spearman’s rho test with the degree of significance at p < 0.05.

Results

The result showed that self-esteem (p = 0.000, r = 0.445) and motivation (p = 0.019, r = 0.246) had correlation with adherence of PLWHA with ART.

Conclusion

PLWHA can increase self-esteem and motivation so that they can improve ART adherence. Further research is expected to use an instrument more objectively as a measurement tool for ART adherence in addition to a questionnaire so as to obtain more accurate and specific results.
Application of calcium carbonate nanocarriers for controlled release of phytodrugs against Xylella fastidiosa pathogen
Authors: Baldassarre Francesca , De Stradis Angelo , Altamura Giuseppe , Vergaro Viviana , Citti Cinzia , Cannazza Giuseppe , Capodilupo Agostina L. , Dini Luciana , Ciccarella Giuseppe
Published: October 2019

Calcium carbonate-based hollow or porous particles are one of the preferred carriers for fabrication of drug delivery systems. We have developed an eco-friendly method to produce calcium carbonate nanocrystals, which have shown biocompatibility and optimal capacity to across cell membrane in human cell lines providing new tools in cancer therapy. The success of drug delivery systems has paved the way for the development of systems for controlled release of agrochemicals. In this work, we exploited calcium carbonate nanocrystals as carriers for targeted release of phytodrugs investigating a potential control strategy for the pathogen Xylella fastidiosa. This pathogen is the causal agent of the Olive Quick Decline Syndrome that is an unprecedented emergency in Italy and potentially in the rest of Europe. We studied nanocrystals interactions with bacteria cells and the application in planta to verify olive plants uptake. Ultrastructural analysis by electron microscopy shown an alteration of bacteria wall following nanocrystals interaction. Nanocrystals were adsorbed from roots and they translocated in plants tissues. Calcium carbonate carriers were able to encapsulate efficiently two types of antimicrobial substances and the potential efficacy was tested in experiment under greenhouse conditions.
Using human epidemiological analyses to support the assessment of the impacts of coal mining on health
Authors: Cortes-Ramirez Javier , Sly Peter D. , Ng Jack , Jagals Paul
Published: October 2019

The potential impacts of coal mining on health have been addressed by the application of impact assessment methodologies that use the results of qualitative and quantitative analyses to support their conclusions and recommendations. Although human epidemiological analyses can provide the most relevant measures of risk of health outcomes in populations exposed to coal mining by-products, this kind of studies are seldom implemented as part of the impact assessment methods. To review the use of human epidemiological analyses in the methods used to assess the impacts of coal mining, a systematic search in the peer review literature was implemented following the PRISMA protocol. A synthesis analysis identified the methods and the measures used in the selected publications to develop a thematic review and discussion. The major methodological approaches to assess the impacts of coal mining are environmental impact assessment (EIA), health impact assessment (HIA), social impact assessment (SIA) and environmental health impact assessment (EHIA). The measures used to assess the impacts of coal mining on health were classified as the estimates from non-human-based studies such as health risk assessment (HRA) and the measures of risk from human epidemiological analyses. The inclusion of human epidemiological estimates of the populations exposed, especially the general populations in the vicinity of the mining activities, is seldom found in impact assessment applications for coal mining. These methods rather incorporate HRA measures or other sources of evidence such as qualitative analyses and surveys. The implementation of impact assessment methods without estimates of the risk of health outcomes relevant to the potentially exposed populations affects their reliability to address the environmental and health impacts of coal mining. This is particularly important for EIA applications because these are incorporated in regulatory frameworks globally. The effective characterization of the impacts of coal mining on health requires quantitative estimates of the risk, including the risk measures from epidemiological analyses of relevant human health data.
Arsenic exposure with reference to neurological impairment: an overview
Authors: Sharma Anupama , Kumar Sunil
Published: October 2019

Arsenic (As) toxicity has become a public health and environmental problem, which is a serious issue in certain parts of the world. Many people are exposed to As through contaminated drinking water, food and soil, through occupation, etc. Chronic As exposure is linked to various hostile health effects including skin problems, cancer, diabetes, cardiovascular disease, reproductive and developmental and neurological problems in exposed subjects. Experimental existing data indicate that chronic As exposure affects the nervous system by impairing the nerve and brain tissues of the exposed animals, and clinical studies indicate that As exposure leads to both central nervous system and peripheral nervous system impairments and also causes depression, memory impairment and difficulty in problem solving, affects body coordination, etc. Various prenatal and postnatal studies with respect to As exposure also suggest that developing offspring and young children are susceptible to As exposure. The only solution to this serious health problem is to stop occupational As exposure and provide As free drinking water to the affected population.
Photocurrent Recombination Through Surface Segregation in Al–Cr–Fe–O Photocathodes
Authors: Stein Helge S. , Zhang Siyuan , Li Yujiao , Scheu Christina , Ludwig Alfred
Published: October 2019

Chemical surface segregation is a design variable in the optimization of phocathodes but has largely been investigated through surface passivation or decoration. In this study a long charge carrier lifetime material, Al–Cr–Fe–O, exhibiting strong photocurrent recombination is investigated for its atomic scale crystallographic and chemical inhomogeneity. Combined scanning transmission electron microscopy and atom probe tomography unveils that insulating Al- and Cr-rich surface layers form during processing. These are discussed to be the primary reason for experimentally observed charge carrier recombination. This study highlights the importance of processing in the design, discovery and optimization of new light absorber materials for photoelectrochemical water splitting.
Closing the loop: An evaluation of student-led module feedback at one UK higher education institution
Authors: Tschirhart Cecile , Pratt-Adams Simon David
Published: October 2019

This article describes how a Student-Led Module Feedback (SLMF) scheme was initiated at one UK University to enhance staff-student relationships and to improve student outcomes. The scheme was developed by academics in partnership with the Students Union (SU) and students. The SLMF aimed to enhance the student experience at a granular level in “real time” during 30 week-long teaching modules. The article defines the SLMF within the research context of the Scholarship of Teaching and Learning and describes how the theme of student-staff partnership runs across the scheme, including during the project management and evaluation phases. It critically reflects on how the scheme has been instrumental in making inroads to improving the experience of students and staff across the university. It analyses the way in which the SLMF is being used by staff and students to co-create action plans to initiate pedagogical changes and thus close the loop of the feedback cycle.
Exploring the impact of The Students Assessing Teaching and Learning Program
Authors: Signorini Adriana , Pohan Cathy
Published: October 2019

The Students Assessing Teaching and Learning (SATAL) Program at the University of California, Merced offers assessment support for faculty and program leads while engaging diverse, cross-program undergraduates in students-as- partners experiences in a work setting. Grounded in the Students as Partners (SaP) principles of respect, responsibility, and reciprocity (Cook-Sather, Bovill, & Felten, 2014), our assessment of the SATAL program reveals benefits for both students and faculty acting as co-creators of teaching and learning. Using the SATAL program as an example, we offer readers a logic model to guide the development of student-faculty-staff partnerships and assess the impact of these programs in a more meaningful and consequential manner. We also provide lessons learned from our evolving SATAL program to support others interested in designing sustainable student assisted assessment partnerships.
The access network: Supporting the construction of social justice physics identities through student partnerships
Authors: Reinholz Daniel Lee , Corrales Adriana , Stone-Johnstone Amelia
Published: October 2019

This paper explores the intersections of Students as Partners (SaP) and identity development. While identity and sense of belonging are known to be key factors for predicting success and persistence in STEM, less is known about how student partnerships can provide space for students to develop their identities. To explore this space, we focus on the Access Network, a coalition funded by the National Science Foundation (NSF) of student-run programs that aims to improve equity in the physical sciences. Qualitative interviews with six student participants showed how SaP created opportunities for students to develop social justice physics identities, which allowed them to bridge traditional notions of what it means to be a physicist with their own social justice commitments. This paper contributes to the rapidly growing SaP literature by studying student partnerships at the scale of a national network of institutions, which contrasts studies that focus on more localized contexts, such as teaching and learning in a single classroom.
Mechanical Evaluation of Concrete Bridge Deck Pavement Systems
Authors: Raab Christiane , Partl Manfred N.
Published: October 2019

Asphalt pavement systems for concrete bridge decks must not only comply with requirements from traffic and environmental exposure but also provide protection of the concrete structures against corrosive attacks from water or deicing agents. These multifunctional expectations are major challenges not only from the material side but also from the experimental side as to the evaluation of the right test methods for assessing the mechanical behavior of the whole multilayer pavement system. In this article, the results of a research project comparing different asphalt pavement systems for alpine regions are presented. These systems consist of hot rolled and mastic asphalt for wearing and protection layers placed on waterproofing systems with polymer bitumen sheets, liquid polymer, and mastic asphalt. The study revealed both the mechanical differences between the different systems and the weaknesses or strengths of different mechanical tests, clearly demonstrating that one has to be careful in interpreting seemingly contradictory results of different test methods. In particular, it was interesting to see that the rutting assessment for some systems differs between cyclic compression tests and rutting tests conducted with a model mobile load simulator.
Paradoxo de Sorites: uma reflexão semântica sobre vagueza
Authors: Behle Nanashara Fagundes
Published: October 2019

No cotidiano, usamos palavras e expressões vagas sem muitas vezes pensarmos sobre isso ou causarmos estranheza em nossos interlocutores. São predicados de vagueza, nos quais a propriedade de ser vago pode não ser tão explícita. Esses predicados são casos incertos ou com a fronteira semântica limítrofe, o que dificulta a clareza da extensão do predicado em si. O objetivo principal deste trabalho, é avaliar os encadeamentos soríticos em uma interface entre a linguística e a lógica. Visto que a vagueza é observada nessas duas áreas do conhecimento. Na lógica, esse tipo de predicado possibilita o desenvolvimento do chamado paradoxo de Sorites, cujo argumento pode ser construído por encadeamento das premissas ou por indução matemática. Usamos, nesse trabalho, o estudo filosófico da vagueza e do paradoxo (PETRILLO, 2005) e, também, o estudo linguístico, em uma semântica de condições de verdade (CHIERCHIA; MCCONNELL-GINET, 1990), para refletirmos sobre como a vagueza é tratada na linguagem.