bluuebunny/crossref_metadata_2025 huggingface dataset:
AVALIAÇÃO DAS DISFUNÇÕES OLFATIVAS NA COVID-19 LONGA
Authors: Paranhos Alna Carolina Mendes , Koury Gisele Vieira Hennemann , Dias Ápio Ricardo Nazareth , Launé Beatriz Freitas , Quaresma Juarez Antônio Simões , Falcão Luiz Fábio Magno , Souza Givago Silva
Published: May 2024

A Disfunção Olfativa (DO) afeta cerca de 20% da população
mundial, predominando em idades mais avançadas (Cavazzana et al., 2017). É caraterizada por uma capacidade reduzida de perceber qualitativamente e/ou quantitativamente os odores (hiposmia), podendo
haver a perda completa da função olfativa (anosmia) (Saltagi et al., 2021). Apresenta forte correlação com o sintoma disgeusia (distorção do paladar transitória ou permanente), ampliando seu impacto na saúde e segurança alimentar (Lopez-Leon et al., 2021; Saltagi et al., 2021).
USO DA COMUNICAÇÃO AUMENTATIVA E ALTERNATIVA EM INDIVÍDUO COM TCE EM NÍVEL III NA ESCALA RANCHO LOS AMIGOS: um relato de caso
Authors: Moura Ana Carolina Tavares , Rodrigues Luzimara Vieira , Almeida Maria Regina Cardoso de , Bentes Joubert Marinho da Silva
Published: May 2024

O Traumatismo Cranioencefálico (TCE) é caracterizado pelo
comprometimento do tecido cerebral devido a lesões que, por sua vez, impactam o funcionamento do sistema neurológico, resultando em alterações biológicas e/ou estruturais nessa região (Mao, 2023),
tratando-se, assim, de uma condição grave, associada a prognósticos desfavoráveis para a funcionalidade plena de um indivíduo e acarretando diversas comorbidades.
LOGISTICS OF MATERIAL FLOWS IN SHIP REPAIR PRODUCTION PROJECTS
Authors: Zaporozhets Iryna , Fateev Nikolai
Published: May 2024

A logistics system is a complexly organised, integrated economic system consisting of interconnected links in a single process of managing material and related flows. Project management in logistics systems uses the application of project management methods and models in the process of designing logistics systems and managing changes in them, as well as solving the problems of managing resource flows in logistics systems. The design, creation and management of logistics systems is accompanied by their presentation as an integral set of elements in certain relationships and connections between them. The logistics system should meet the goals of their design and management. The article outlines elements of the mechanism of logistics management of material costs of ship repair production. Efficient use of the company's resources is possible through the systematic development of a system of organisational and technical measures to reduce costs. All cost-cutting measures are closely interrelated and comprehensive, reflecting the relationship of each of them with the entirety of ship repair production elements. The paper substantiates the production features of a ship repair enterprise and analyses the factors that determine the level of costs. It identifies types of ship repair works and stages of preparation of vessels for repair, which makes it possible to plan costs for formation of the production programme. This text presents the production structure of a ship repair enterprise and discusses the peculiarities of product costing. Ship repair companies use planned, indicative, estimated (technical) and reporting costings. This makes it possible to develop a mechanism for managing the costs of ship repair projects and the production process of a ship repair company.
THE IMPACT OF FOREIGN INVESTMENT ON UKRAINE'S COMPETITIVENESS AFTER THE WAR
Authors: Kohut Maryana
Published: May 2024

The purpose of the paper is to critically analyse and understand how foreign investment can affect and potentially improve Ukraine's competitiveness in the global market after the war. Methodology. This study aims to analyse the various aspects and dimensions of foreign investment, in particular direct investment flows, and their impact on key sectors of the economy in Ukraine in the post-war period. In addition, it attempts to assess the challenges and opportunities that foreign investment creates in the context of rebuilding and modernising Ukraine's infrastructure, enhancing its technological and innovation potential, and strengthening its labour force and industrial base. The survey results showed that foreign investment has had a significant positive impact on Ukraine's economic growth in the post-war period, especially in the restoration of key industries and infrastructure. FDI plays an important role in attracting advanced technologies and expertise to Ukraine, thereby increasing its competitiveness. The document emphasises the need for policy reforms to create a more favourable investment climate, including improved legal protection for investors, anti-corruption measures and increased efficiency of the bureaucracy. The results of the study point to the existing challenges in attracting foreign investment, such as political instability, infrastructure deficit and unclear investment legislation. Finally, the publication forecasts the long-term impact of foreign investment on economic stability and growth trajectory in Ukraine, which leads to cautiously optimistic conclusions. Practical implications. The research aims to provide insights and recommendations on how Ukraine can effectively use foreign investment to rebuild its economy, increase its global competitiveness and ensure long-term sustainable development in the post-war period. The SWOT analysis in this article helps to identify strategic areas for improvement and capitalisation. It can help them formulate policies to improve the investment climate by focusing on strengthening strengths, mitigating weaknesses, seizing opportunities and protecting against threats. Value/Originality. The value and originality of the paper lies in its comprehensive and detailed study of how foreign investment can be a key factor in reforming and reviving Ukraine's economy after the war. The paper specifically examines the post-war economic landscape of Ukraine, a topic that has not been widely studied. It provides a fresh perspective on the challenges and opportunities for a country recovering from war.
Corporate Social Responsibility’s Hidden Power in context of Pakistan: Amplifying Firm Performance
Authors: Naeem Muhammad , Rehman Abdul , Mehboob Asim , Shah Abdali Ahmad
Published: May 2024

This research explores the impact of Corporate Social Responsibility on the performance of firms listed on the Pakistan Stock Exchange in the cement and sugar industries. This link is examined using panel data derived from financial reports from 2013 to 2022. The study includes generally used performance indicators, such as Return on Assets, Return on Equity, and Earnings per Share, by previous literature. The corporate social responsibility data is generated from information released by firms about philanthropic activities, contributions, and R&D projects. The study also takes into account other financial and control variables such as firm size, firm age, and leverage. The random sampling approach is used to create a sample of 28 non-financial listed organizations. Several statistical tests are used in the study, including panel data technology, correlation, random effect, and fixed effect models. According to the findings of this study, corporate social responsibility has a favorable impact on company performance. These findings are consistent with previous research done in developing nations and are relevant for Pakistani businesses, which operate in different economic environments than their Western counterparts. This study provides significant insights for organizations and regulatory agencies. Furthermore, the paper makes suggestions for future research, such as the assessment of context variables such as ownership structure, the consideration of other periods, and the investigation of other industrial sectors.
CSR Disclosure and Bank’s Financial Performance Nexus: Evidence from Pakistan.
Authors: Hafeez Bilal
Published: May 2024

Present research intends to evaluate the nexus among the corporate social responsibility (CSR) disclosure and financial effectiveness of banking industry in Pakistan. This investigation applies a quantitative research approach using panel data from a sample of Pakistan’s commercial banking institutions over timeframe limited from 2009 to 2020. The outcomes of mixed effect model visualize that there is inverse significant association among CSR disclosure ROE. Whereas no statistically significant linked in the context of short-term financial performance, by using a proxy of ROA. The results suggesting that the focus on CSR events and initiatives may have a detrimental effect on financial effectiveness. It is generally acknowledged that CSR offers numerous non-financial benefits, such as enhancing social media campaigns and luring ethical investors from both domestic and foreign markets. In developing countries context (i.e., Pakistan), we can conclude that the “cost of the CSR initiatives” and “shift of focus view” can affect the performance of banking industry. The lack of a positive correlation among corporate social responsibility (CSR) and financial performance in the Pakistani financial services sector can be attributed to a lack of interest and engagement in socially conscious investing. These findings indicate that the adoption of socially responsible investment has not gained significant cultural traction in Pakistan. The results emphasize the importance of banks, regulators, and stakeholders reassessing the balance between social responsibility and financial performance, considering the possible negative consequences of revealing CSR initiatives.
Role of an organizational psychologist in improving and accelerating work engagement
Authors: Tunio Samreen , Tunio Dr. Muhammad Nawaz
Published: May 2024

Purpose-. Work is an integral part of human life, where progress and productivity are more expected or demanded but an employee’s mental health is rarely considered a priority. Therefore, the purpose of this study is to highlight the significance of placing an organizational psychologist at the forefront of workplaces, to encourage the mutual wellbeing of individuals and organizations.
Approach- This is a conceptual paper that builds upon a thorough review of existing conventional management theories to identify key cracks in knowledge about the importance of organizational psychologists to deal with a diverse range of social and behavioral issues within organizations considering common psychological safety at work. We start by conducting a content analysis of a few articles in the field that discuss the ‘why’ for organizational psychologists under work climate and continue with the strategies that can help organizations in reducing work-related stressors and improving social working conditions, and training.
Findings- This study proposes a model that can be used to consider individual (employee) and situational (organizational) psychological wellness by underlining the direct interaction of organizational psychologists in managing human resources. The model of this study elucidates that collective wellbeing relies equally on organizational support teams (HR) and organizational psychologists through collective mindfulness.
Originality/Value- Many studies are conducted in different countries with different perspectives of the organization and HR, where the role and importance of the organizational psychologist or psychologist in the organizations were highlighted, yet the concept is still blurry in Pakistan, and thus, this study is a novel contribution in a geographical context.
Keywords- Psychology, Organizational psychologist, Employee wellbeing, Corporate wellness, Organizational development
Paper type- Conceptual Paper
The Effect of Solution-Focused Approach on Reducing Smartphone Addiction
Authors: Sağar Mehmet Enes
Published: May 2024

The aim of this study is to examine the effect of solution-focused group counseling on reducing smartphone addiction among university students. The research is an experimental study with experimental-control group with pre-test, post-test and follow-up measurement design. The study group of the research consisted of 22 university students (10 females and 12 males). 11 of these students are in the experimental group (5 females and 6 males) and 11 of them are in the control (5 females and 6 males) group. A solution-focused group psychological counseling program was applied to the experimental group to reduce smartp-hone addiction, consisting of six sessions (90-120 minutes once a week) developed by the researcher. Kontrol grubuna ise herhangi bir çalışma yapılmamıştır. In this study, "Smartphone Addiction Scale" and "Personal Information Form" were used as data collection tools. The data obtained from this study were analyzed using the Mann Whitney U Test and the Wilcoxon Signed-Ranks Test. The findings of the study revealed that the solution-focused group was more effective than the control group. In addition, it was observed that this effectiveness was preserved with the follow-up studies carried out at the end of three months
Pengaruh Profesional Identity pada Turnover Intention dengan Employee Enggagement dan Job Satisfaction sebagai Variabel Mediasi
Authors: Missye Missye , Hosen Chandra
Published: May 2024

 The high level of employee turnover intention is an important problem for companies. Companies to make efforts to increase job satisfaction and employee engagement in their work, so that it will have an impact on reducing turnover intentions. Research was conducted on employees to analyze the influence of professional identity on turnover intention with employee engagement and job satisfaction as mediation. This research uses a quantitative approach using a questionnaire filled out by 42 respondents who work at company.. techniques probability sampling with simple random sampling. The results show that professional identity, job satisfaction and work engagement have a negative influence on turnover intention. Meanwhile, professional identity has a positive effect on employee engagement and job satisfaction. Job satisfaction and employee engagement are able to mediate the influence of professional identity on turnover intention. In an effort to minimize employees turnover intention , companies need to improve their professional identity, which can have an impact on employee engagement and employee job satisfaction which will have the effect of lowering turnover intention.
Efek Mediasi Kompetensi Atas Pengaruh Proses Seleksi Pegawai Terhadap Persepsi Kinerja Pegawai
Authors: Sitorus Tigor , Ghozi Ali
Published: May 2024

This study aims to extend a model research empiric the influence of process selection of employee to employee performance mediated by Competency of employee. Population ini this study are employees at Inspectorate General of Ministry of Religion Affair. The sampel was used in this study are 112 respondents by sensus method. Data analysis was conducted by using Structural Equation Modeling (SEM) using AMOS 21.0 (Analysis of Moment Structures). The SEM analysis result has fulfilled Goodness of Fit Index Criteria, and has a high loading factor. The result shows that; (1) Process selection of employee has positive and significantly influence on the Competency of employee, (2) Process selection of employee has negative and significantly influence on the employee performance, (3) Competency of employee has positive and significantly influence on the employee performance. Therefore mediated effect of Competency of employee greater than direct effect process selection of employee to employee performance.
Keywords: Selection, Competency, Performance, Employee
Propuesta para el establecimiento de nuevas áreas de aviso por temperaturas máximas en la Región de Murcia (España)
Authors: Martí Talavera Javier , Moltó Mantero Enrique , Sánchez Díaz Germán , Sánchez Almodóvar Esther
Published: May 2024

Uno de los grandes problemas actuales que tienen las alertas meteorológicas en España es su escasa adaptabilidad a las particularidades climáticas y poblacionales de cada territorio, lo que repercute en la existencia de unos umbrales y unas áreas de avisos que, en ocasiones, son poco acordes a las condiciones de cada lugar. En este trabajo se emplean las temperaturas máximas como ejemplo para crear una nueva metodología que permita solventar esos problemas en la Región de Murcia. Se seleccionaron los datos de temperaturas máximas diarias durante el verano meteorológico en 84 observatorios en el periodo 2000-2019. Se calcularon para cada estación los percentiles 95, 97 y 99 y se generaron tres mapas interpolados usando kriging universal. Mediante un análisis de superposición se generaron las distintas áreas de aviso y se establecieron unos umbrales de temperatura máxima basados en tres niveles. Con esta propuesta metodológica, se han obtenido 19 áreas de aviso meteorológico basadas en la agregación de polígonos de códigos postales. Esta zonificación implica una mejor adecuación del aviso meteorológico en el territorio, y un mayor grado de eficiencia en el plano de la protección de la población y de la gestión de la preemergencia.
Síndrome de arteria mesentérica superior
Authors: Jaimes-González Claudia Viviana Jaimes-González , Pereira-Velásquez María José , Rodríguez-Fajardo Carlos Andrés , Unigarro-Villota Juan Pablo
Published: May 2024

El síndrome de la arteria mesentérica superior (SAMS), también conocido como síndrome de Wilkie, es una obstrucción intestinal alta ocasionada por la compresión vascular de la tercera porción del duodeno por la arteria mesentérica superior sobre la aorta abdominal 1,2 (Figura 1). Es una patología poco frecuente, con una incidencia del 0,2 %, más común en mujeres (2:1) entre los 10 y 30 años, principalmente en pacientes con pérdida de peso rápido, que conlleva alta morbimortalidad 3,4.
Razones para escribir y publicar artículos científicos
Authors: Petrone Patrizio , Mónica Bejarano
Published: May 2024

Existen razones para publicar. Al decir de Scott Fitzgerald, “no tienes que escribir porque quieres decir algo, tienes que escribir porque tienes algo que decir”. El continuo incremento en las obligaciones asistenciales, docentes y administrativas, sumado al poco reconocimiento de las instituciones y al escaso estímulo económico atentan contra el desarrollo académico de los cirujanos. Con esos argumentos, la gran mayoría de los cirujanos no consideran importante publicar, sin embargo, la productividad científica aumenta la reputación de los servicios de cirugía e incrementa la posibilidad de obtener recursos económicos. Por este motivo, el rol de las publicaciones científicas es cada vez más importante 1.
Inflammatory Bowel Diseases and the Efficacy of Probiotics as Functional Foods
Authors: Vitetta Luis , Oldfield Debbie , Sali Avni
Published: May 2024

Adverse intestinal microbiome profiles described as a dysbiotic gut are a complicit etiological operative factor that can progress and maintain inflammatory sequelae in the intestines. The disruption of the gut microbiome that ensues with intestinal dysbiosis is, for example, posited by decreases in the alpha-diversity of the gut microbiome, which is characterized by significant reductions in the abundance of bacterial members from the Bacteroidetes and Firmicutes phyla. Proteobacteria have often been recognized as gut microbial signatures of disease. For example, this happens with observed increases in abundance of the phyla Proteobacteria and Gammaproteobacteria, such as the adherent-invasive Escherichia coli strain, which has been significantly linked with maintaining inflammatory bowel diseases. Research on the administration of probiotics, often identified as gut-functional foods, has demonstrated safety, tolerability, and efficacy issues in treating inflammatory bowel diseases (IBDs). In this narrative review, we explore the efficacy of probiotics in treating IBDs with bacterial strain- and dose-specific characteristics and the association with multi-strain administration.
Plants-occurring Anthraquinones as Photosensitive Compounds for Photodynamic Method: A Critical Overview
Authors: Mantareva Vanya , Braikova Diana , Lazarova Irina , Genova Tsanislava
Published: May 2024

The review focuses on the recent knowledge on natural anthraquinones (AQs) of plant origin and their potential for application in an exclusive medicinal curative and palliative method named photodynamic therapy (PDT). Green approach to PDT is associated with photosensitizers (PS) from plants or other natural sources and excitation light in visible spectrum. The investigations of plants are of high research interests due to their unique health supportive properties as herbs and the high percentage availability to obtain compounds with medical value. Up-to-date many naturally occurring compounds with therapeutic properties are known and are still under investigations. Some natural quinones have already been evaluated and clinically approved as anti-tumor agents. Recent scientific interests are beyond their common medical applications but also in directions to their photo-properties as natural PSs. The study presents a systematic searches on the latest knowledge on AQ derivatives that are isolated from the higher plants as photosensitizers for PDT applications. The natural quinones have been recognized with functions of natural dyes since the ancient times. Lately, AQs have been explored due to their biological activity including the photosensitive properties useful for PDT especially towards medical problems with no other alternatives. The existing literature’ overview suggests that natural AQs possess characteristics of valuable PSs for PDT. This method is based on an application of a photoactive compound and light arrangement in oxygen media, such that the harmful general cytotoxicity could be avoided. Moreover, the common anticancer and antimicrobial drug resistance has been evaluated with very low occurrence after PDT. Natural AQs have been focused the scientific efforts to further developments because of the high range of natural sources, desirable biocompatibility, low toxicity, minimal side effects and low accident of drug resistance, together with their good photosensitivity and therapeutic capacity. Among the known AQs, only hypericin has been studied in anticancer clinical PDT. Currently, the natural PSs are under intensive research for the future PDT applications for diseases without alternative effective treatments.
Regulation of TAK–TAB Complex Activation through Ubiquitylation
Authors: Zhang Jie , Cao Lei , Lyu Lijuan , Qi Wenqian , Yang Wei , Ren Ruiqing , Kao Chunyu , Zhang Yun , Zhang Cheng , Zhang Meng
Published: May 2024

Transforming growth factor-β (TGF-β) activated kinase 1 (TAK1), also named mitogen-activated protein kinase 7 (MAPK7), forms a pivotal signaling complex with TAK1-binding proteins (TAB1, TAB2, and TAB3), orchestrating critical biological processes, including immune responses, cell growth, apoptosis, and stress responses. Activation of TAK1 by stimuli, such as tumor necrosis factor α (TNFα), interleukin-1β (IL-1β), and Toll-like receptors (TLRs), underscores its central role in cellular signaling. Given the critical role of the TAK1-binding protein (TAK1–TAB) complex in cellular signaling and its impact on various biological processes, this review seeks to understand how ubiquitination thoroughly regulates the TAK1–TAB complex. This understanding is vital for developing targeted therapies for diseases where this signaling pathway is dysregulated. The exploration is significant as it unveils new insights into the activity, stability, and assembly of the complex, underscoring its therapeutic potential in disease modulation.
Enhancing the Antibacterial Impact of Lipopeptide Extracted from Bacillus licheniformis as a Probiotic against MDR Acinetobacter baumannii
Authors: Hosseini Bafghi Mahdi , Ghanipour Farangis , Nazari Razieh , Aghaei Seyed Soheil , Jafari Parvaneh
Published: May 2024

Background: The antibiotic resistance of microorganisms is escalating rapidly. Infections caused by opportunistic pathogens in immunocompromised individuals have prompted researchers to seek for potent and safe antibacterial agents. The purpose of this investigation was to explore the suppression of virulence gene expression, specifically the pga operon genes responsible in biofilm formation in Acinetobacter baumannii, through the utilization of metabolites obtained from probiotic bacteria. Methods: To assess the antimicrobial properties, standard strains of five probiotic bacteria were tested against a standard strain of multidrug-resistant (MDR) A. baumannii employing the agar gel diffusion technique. Following the identification of the most potent probiotic strain (Bacillus licheniformis), the existence of its LanA and LanM genes was confirmed using the polymerase chain reaction (PCR) test. High-performance liquid chromatography (HPLC) and fourier-transform infrared spectroscopy (FTIR) techniques were employed to identify the intended metabolite, which was found to be a lipopeptide nature. The minimum inhibitory concentration (MIC) values and anti-biofilm activity of the targeted metabolite were determined using a dilution method in 96-well microplates and field emission scanning electron microscopy (FE-SEM). Real-time PCR (qPCR) was utilized for comparing the expression of pga operon genes, including pgaABCD, in A. baumannii pre- and post-exposure to the derived lipopeptide. Results: The MIC results indicated that the probiotic product inhibited the growth of A. baumannii at concentrations lower than those needed for conventional antibiotics. Furthermore, it was observed that the desired genes’ expression decreased due to the effect of this substance. Conclusions: This research concludes that the B. licheniformis probiotic product could be a viable alternative for combating drug resistance in A. baumannii.
The Role of PTEN in Nasopharyngeal Carcinoma
Authors: Chen Yan , Xu Shuli , He Yingchun , He Lan
Published: May 2024

Nasopharyngeal carcinoma (NPC) is an aggressive head and neck tumor that is influenced by a variety of molecular factors during its pathogenesis. Among these, the phosphatase and tensin homolog (PTEN) plays a crucial role in regulatory networks. This article systematically reviews the multifaceted functions of PTEN in NPC, including its roles in inhibiting cell proliferation, regulating migration and invasion, promoting autophagy and apoptosis, and influencing resistance to radiotherapy. Molecular factors such as long non-coding RNA, microRNA (miRNA), and circular RNA can modulate PTEN through various pathways, thereby impacting the biological behavior of NPC. In addition, PTEN is involved in regulating the tumor microenvironment of NPC, and its interaction with the Epstein-Barr virus has also recently become a focus of research. A comprehensive understanding of the PTEN regulatory network provides a foundation for future personalized and targeted therapeutic strategies. This study expands our understanding of the pathogenesis of NPC and suggests new directions in the field of tumor biology and NPC treatment.
Newly Isolated Limosilactobacillus reuteri B1/1 Modulates the Expression of Cytokines and Antimicrobial Proteins in a Porcine ex Vivo Model
Authors: Kiššová Zuzana , Štofilová Jana , Mudroňová Dagmar , Karaffová Viera
Published: May 2024

Background: The epithelia of the intestine perform various functions, playing a crucial role in providing a physical barrier and an innate immune defense against infections. By generating a “three-dimensional” (3D) model of cell co-cultures using the IPEC-J2 cell line and porcine blood monocyte-derived macrophages (MDMs), we are getting closer to mimicking the porcine intestine ex vivo.Methods: The effect of Limosilactobacillus reuteri B1/1 and Limosilactobacillus fermentum CCM 7158 (indicator strain) on the relative gene expression of interleukins (IL-1β, IL-6, IL-8, IL-18 and IL-10), genes encoding receptors for TLR4 and TLR2, tight junction proteins such as claudin-1 (CLDN1), occludin (OCLN) and important antimicrobial proteins such as lumican (LUM) and olfactomedin-4 (OLMF-4) was monitored in this model. Results: The results obtained from this pilot study point to the immunomodulatory potential of newly isolated L. reuteri B1/1, as it was able to suppress the enhanced pro-inflammatory response to lipopolysaccharide (LPS) challenge in both cell types. L. reuteri B1/1 was even able to up-regulate the mRNA levels of genes encoding antimicrobial proteins LUM and OLFM-4 and to increase tight junction (TJ)-related genes CLDN1 and OCLN, which were significantly down-regulated in LPS-induced IPEC-J2 cells. Conversely, L. fermentum CCM 7158, chosen as an indicator lactic acid bacteria (LAB) strain, increased the mRNA levels of the investigated pro-inflammatory cytokines (IL-18, IL-6, and IL-1β) in MDMs when LPS was simultaneously applied to basally deposited macrophages. Although L. fermentum CCM 7158 induced the production of pro-inflammatory cytokines, synchronous up-regulation of the anti-inflammatory cytokine IL-10 was detected in both LAB strains used in both cell cultures. Conclusions: The obtained results suggest that the recently isolated LAB strain L. reuteri B1/1 has the potential to alleviate epithelial disruption caused by LPS and to influence the production of antimicrobial molecules by enterocytes.
Transcriptional Regulation of the Lineage-Determining Gene PU.1 in Normal and Malignant Hematopoiesis: Current Understanding and Therapeutic Perspective
Authors: Korczmar Emilia A. , Bookstaver Anna K. , Ober Ellison , Goldfarb Adam N. , Tenen Daniel G. , Trinh Bon Q.
Published: May 2024

The ETS transcription factor PU.1 plays an essential role in blood cell development. Its precise expression pattern is governed by cis-regulatory elements (CRE) acting at the chromatin level. CREs mediate the fine-tuning of graded levels of PU.1, deviations of which can cause acute myeloid leukemia. In this review, we perform an in-depth analysis of the regulation of PU.1 expression in normal and malignant hematopoiesis. We elaborate on the role of trans-acting factors and the biomolecular interplays in mediating local chromatin dynamics. Moreover, we discuss the current understanding of CRE bifunctionality exhibiting enhancer or silencer activities in different blood cell lineages and future directions toward gene-specific chromatin-targeted therapeutic development.
Recent Development of Biodegradable Occlusion Devices for Intra-Atrial Shunts
Authors: Li Yi-Fan , Chen Ze-Wen , Xie Zhao-Feng , Wang Shu-Shui , Xie Yu-Mei , Zhang Zhi-Wei
Published: May 2024

Atrial septal defect (ASD) is the third most common type of structural congenital heart defect. Patent foramen ovale (PFO) is an anatomical anomaly in up to 25% of the general population. With the innovation of occlusion devices and improvement of transcatheter techniques, percutaneous closure has become a first-line therapeutic alternative for treatment of ASD and PFO. During the past few decades, the development of biodegradable occlusion devices has become a promising direction for transcatheter closure of ASD/PFO due to their biodegradability and improved biocompatibility. The purpose of this review is to comprehensively summarize biodegradable ASD/PFO occlusion devices, regarding device design, materials, biodegradability, and evaluation of animal or clinical experiments (if available). The current challenges and the research direction for the development of biodegradable occluders for congenital heart defects are also discussed.
Differentiation in Cognitive Abilities Beyond g: The Emergence of Domain-Specific Variance in Childhood
Authors: Bardach Lisa , Kalinowski Robert , Bailey Drew H
Published: May 2024

Understanding how the structure of cognitive abilities changes depending on age and ability (age and ability differentiation) has critical implications for cognitive ability assessments and cognitive developmental theories. Most differentiation research has focused on general intelligence; however, as children increasingly invest in specific domains and school-taught subjects, we argue that these investments should rather affect their domain-specific ability structures. Leveraging a representative longitudinal sample of 17,979 U.S. children who were assessed in mathematics, reading, science, working memory, and cognitive flexibility, we found that loadings on a general intelligence factor remained similar, whereas most domain-specific factor loadings increased over time. Hence, age and ability differentiation are conceptually distinct, with the former pertaining to specific abilities and the latter to general intelligence. We find some evidence that domain-specific abilities can compensate for lower general intelligence. Overall, our study motivates a nuanced understanding of children’s cognitive development.
The Political Economy of Industrial Policy
Authors: Juhász Réka , Lane Nathaniel
Published: May 2024

We examine the ways in which political realities shape industrial policy through the lens of modern political economy. We consider two broad “governance constraints”: i) the political forces that shape how industrial policy is chosen and ii) the ways in which state capacity affects implementation. The framework of modern political economy suggests that government failure is not a necessary feature of industrial policy; rather, it is more likely to emerge when countries pursue industrial policies beyond their governance capacity constraints. As such, our political economy of industrial policy is not fatalist. Instead, it enables policymakers to constructively confront the challenges of policy design.
Meta-judgment: Meta-theories and beliefs about good judgment across societies
Authors: Grossmann Igor , Eibach Richard
Published: May 2024

We introduce the concept of ‘meta-judgment’ to provide a framework for understanding folk standards people use to navigate everyday decisions. Defined as a set of meta-theories and beliefs about different types of judgment, meta-judgment serves as the guiding principle behind the selection and application of reasoning strategies in various contexts. We review emerging studies on meta-judgment to identify common dimensions, such as intuition versus deliberative reasoning and rationality versus reasonableness. These dimensions are examined across multiple societies. Our findings illuminate an apparent paradox: universal adaptive challenges produce largely consistent folk standards of judgment across cultures, whereas situational demands drive systematic within-person variability. Meta-judgment offers a comprehensive framework for understanding diverse reasoning patterns in individual and cross-cultural contexts, calling for greater attention to the ecologically-sensitive study of within-person judgmental variability.
Qualitative analysis of a patient’s experience of ketamine-assisted psychotherapy for substance use disorder: Empirical synergies with twelve-step programs.
Authors: Petrovitch Dan , Spinks Jacob , Yoo Hannah B , Kerr Lindsay , Willms Joshua , Jurek Mary Katherine , Wanzor-Box Rachel , Littlefield Andrew K. , McCauley Ben
Published: May 2024

Ketamine has demonstrated early promise for treating substance use disorder (SUD). However, ketamine is also a recreational substance, which raises concerns about its clinical applications to SUD. Despite the emerging evidence for ketamine-based approaches for SUD and these potential risks, little has been published on methods for integrating ketamine-assisted psychotherapy (KAP) with existing pharmacologic, psychosocial, and community-based treatment paradigms (e.g., 12-step programs). Here, we present the case of a 28-year-old female treated for SUD involving misuse of alcohol and prescription opioids. We executed an inter-clinic, collaborative treatment plan that involved a psychedelic, ketamine-based regimen in combination with extant psychosocial and 12-step-based treatments for SUD. Qualitative analysis of the patient’s lived experience suggested that ketamine played an important role in her self-reported experience of recovery, as she attributed psychological and spiritual changes to her ketamine treatments. Specifically, this report highlights the extent to which the patient’s ketamine-induced experiences overlapped with the 12 steps, which will be useful for clinicians treating other 12-step-involved SUD patients with ketamine. Additionally, we detail specific clinical practices that we implemented for managing the unique risks of ketamine interventions as SUD treatments.
The Impact of IMSI Catcher Deployments on Cellular Network Security: Challenges and Countermeasures in 4G and 5G Networks
Authors: Kareem Karwan Mustafa
Published: May 2024

IMSI catchers, also known as "Stingrays" or "cell site simulators," are rogue devices posing grave threats to cellular network security. With the evolution of 4G and 5G networks, these devices have grown more sophisticated, enabling unauthorized interception and manipulation of cellular communications. This paper outlines their impact on network security, including unauthorized data collection and potential privacy breaches. It highlights risks such as financial fraud and surveillance, and suggests countermeasures like signal analysis, encryption, and authentication mechanisms. However, the effectiveness of these measures in 4G and 5G environments is debated. The paper underscores the need for enhanced encryption, authentication, and detection techniques. It also stresses regulatory measures to govern IMSI catcher deployment and usage, safeguarding user privacy and security.
The Kids Are All Right: Futurity and Black German Childhood in SchwarzRund’s Biskaya (2017)
Authors: Layne Priscilla
Published: May 2024

SchwarzRund’s Biskaya (2017) is an “Afroqueer” novel that follows the travails of Tue, a queer Black German woman whose life is marked by the quotidian struggles of queer Black folx in Germany. However, Biskaya is also a work of fantasy, since SchwarzRund created an island (Biskaya) in the Bay of Biscay along the southern coast of Spain and France. In the novel Biskaya is home to African-descended people who have both voluntarily and involuntarily migrated to Europe as part of the labour market for centuries. In this article I examine the role of children in the novel’s discussions about Black German futurity. I argue that in Biskaya, SchwarzRund combines Afrofuturist aesthetics, Black feminist thought, and queer futurity to present us with a utopia that is not perfect but is in a state of becoming thanks to people like Tue, who realize the importance of being hopeful and working towards a better future. I focus on the role that kinship plays in this Black, queer futurity, because Tue’s relationships, both biological and non-biological, both with peers and with elders and juniors, are a key part of her transformation into being more hopeful about the future. While it is the importance of non-biological kinship ties in the novel that helps make it so queer, it is the intergenerational relationships that make the novel Afrofuturist. I look at how children in the novel allow SchwarzRund to pose several questions about futurity that can help unite Black Germans across genders, sexualities, and generations and empower all Black German folx to see themselves as agents of change.
Utopian Spaces and Their Everyday Traces in Thomas Stuber’s In den Gängen (2018)
Authors: McCarthy Margaret
Published: May 2024

This article examines utopian elements in Thomas Stuber’s 2018 film In den Gängen. Despite the neoliberal forces that constrain a group of supermarket shelf stackers in the former East Germany, the film’s characters exhibit congenial bonds in the face of alienated work. Strikingly, their encounters with machines also convey an other-directedness and improvised conviviality, or energy that enables them to devise bonds in fleeting moments. As much as the film presumes a foreclosed-on socialist utopia, it also depicts a range of contemporary challenges to neoliberalism, including practices of commoning, non-normative forms of relationality, and human-machine interactions that gesture towards a posthumanist selfhood. At the same time, the three main characters’ personal circumstances and histories necessarily impact their ability to benefit from these elements. Both age and gender play crucial roles in their individual fates, and not all of them thrive within their caring, other-directed community. Ultimately, In den Gängen suggests the possibility of mundane existences gesturing towards superlative futures.
ANALYSIS OF THE STATE AND TRANSFORMATIONS OF RETAIL: GLOBAL TRENDS AND THE UKRAINIAN SEGMENT
Authors: KOVALCHUK Svitlana
Published: May 2024

The article provides an analysis of the current state and transformations of the retail sector, particularly in the context of global trends and their impact on the Ukrainian segment. Retail undergoes significant transformations driven by both global trends and local challenges. The COVID-19 pandemic and the war in Ukraine have substantially influenced consumer behavior and market dynamics. The aim of the article is to investigate the current state and prospects of the retail sector's development considering global trends, the impact of the pandemic, and military aggression in Ukraine. Key aspects of changes in consumer demand, the evolution of retail store formats, and the influence of technological innovations and digital transformation on the retail market are explored. The author analyzes global trends and provides context for understanding their impact on the Ukrainian retail sector. The study also covers the prospects for development and opportunities for Ukrainian retail companies in the context of changes in the global economy. Retail is undergoing a period of transformations intensified by the pandemic and military aggression. Ukrainian retail faces numerous challenges but also has opportunities for adaptation and development. Retail adapts to changes in the world, and it is important to find a balance between sustainability, efficiency, digital technologies, and emotional connection with customers. The results of the analysis may be useful for managers and entrepreneurs interested in the retail business and its transformations both globally and locally.
Safeguarding Children's Rights: Ensuring Hearing and Consent in Family Cases Post-Parental Divorce with Recommendations
Authors: Abbasi Ghulam Nabi , Channa Sajjad Ali , Khokhar Ameer Ali
Published: May 2024

The lacunas and inadequacies present in the provisions with respect to a child's custody in Pakistan are featured in this research paper. It contends that flaws existing in the Guardian and Wards Act of 1890 provide the domestic courts to practice vast discretionary powers while entertaining the litigations related to custody of children, in this manner prompting contrary judgments. This paper contains the perusal of the provisions of the Act of 1890, and the judicial precedents, for the purpose of identifying loopholes and deficiencies. Besides, it also includes what other Islamic and Western developed countries give rights to the children in this matter. Some particular arrangements are proposed to harmonize existing fragmented practices. Other than this, some laws and remedies are proposed, which other developed countries of the world provide, to fill the lacunas and loopholes in the provisions of the Act of 1890 for the wellbeing of children.
Comparative analysis of Family Laws in Pakistan and Islamic Injuctions in this Regard
Authors: Tahir Muhammad , Shahid Muhammad
Published: May 2024

“No ination can ever be worthy of its existence that cannot take its women along with the men.” Mohammad Ali Jinnah, Founder of Pakistan” (Russell & Catharine, 2007).The legal status of Muslim women, especially in family relations, has been the subject of considerable international academic and media interest. The right to marital freedom is a constitutional right in Pakistan and demonstrates that in ia country in which women’s rights are notoriously and brutally violated, female divorce rights stand as a ray of light amidst the “darkness” of ithe igeneral legal status of Pakistani women. Contrary to the conventional wisdom construing Islamic law as opposed to women’s rights, the constitutionalization of Islam in Pakistan has proven to be a potent tool in the service of women’s interests.
Political and Public Discourse in the backdrop of 'Regime Change' in Pakistan (2022): A Thematic Analysis of the Facebook pages of PTI, PML-N and PPP
Authors: Ahmed Naseer , Ghauri Muhammad Junaid , Bukhari Syed Abid Ali
Published: May 2024

In today’s day and age, the social media platforms like Facebook and Twitter have converted a rather conventionally one way ‘political communication’ process into an effective and influential two-way communication process. This two-way communication process has an impact on the political communication phenomenon all around the world. Bearing in mind this aspect the researcher has attempted to explore how and to what extent the ‘public discourse’ matched or differed from the ‘political discourse’ regarding the political ‘regime change’ in Pakistan that took place in the first half of the April 2022. Employing the ‘Framing’ as theoretical basis the researcher has attempted to determine how the ‘regime change’ was framed in the political and public discourse. The researcher has employed thematic analysis as methodological tool in this study to identify, analyze and interpret the meanings within the political and public discourse in the backdrop of the ‘regime change’ appeared in the Facebook pages of the top three political parties in Pakistan i.e. Pakistan Tehreek-E-Insaaf (PTI), Pakistan Muslim League- Nawaz (PML-N) and Pakistan Peoples Party (PPP).
Daydreaming and Self-regulation among Fashion Designer Students: The Mediating Role of Creativity
Authors: Malik Muhammad Jawad Nasir , Naseem Zarghuna , Hanif Nimra
Published: May 2024

This research was done to explore the relationship between adaptive daydreaming, creativity, and self-regulation
among fashion design students. The study also explored the mediating role of creativity between adaptive daydreaming and self-regulation. The sampling was purposive for the collection of data. A sample (N=200) was collected from students of fashion designing from different universities. The participants (men =95, women =105) average age was 20.83 years. The questionnaire included three assessment measures: (i) short imaginal process inventory for measuring daydreaming (Antrobus, 2010), (ii) Runco ideational behavior scale for creativity (Runco & Plucker, 2001) (iii) and short form of self-regulation questionnaire (Brown et al., 1999). Results of this study highlighted a significant positive relationship between adaptive daydreaming, creativity, and self-regulation among fashion designer students. However, a significant inverse relationship between maladaptive daydreaming and self-
regulation was observed.
СОЦІАЛЬНО-ЕКОНОМІЧНА РОЛЬ ТА СПЕЦИФІКА ФУНКЦІОНУВАННЯ І РОЗВИТКУ РИНКУ СІЛЬСЬКОГОСПОДАРСЬКОЇ ПРОДУКЦІЇ
Authors: БАРНА Марта , ІВАНЮК Юрій
Published: May 2024

У статті акцентовано увагу на питаннях теоретико-методичних засад функціонування та розвитку ринку праці. Визначено соціально-економічну роль та специфіку функціонування ринку сільськогосподарської продукції. Метою статті визначено узагальнення теоретико-методичних засад соціально-економічної ролі та особливостей функціонування і розвитку ринку сільськогосподарської продукції. На підставі узагальнення теоретико-методичних засад дослідження ринку сільськогосподарської продукції встановлено, що в основу його сутнісно-змістової характеристики потрібно закладати складний багаторівневий механізм, що опосередковує процеси і відносини, які виникають в ході виробництва, розподілу, обміну та споживання сільськогосподарської продукції, а також забезпечує узгодження (через такі інститути, як попит і пропозиція, ціна тощо) соціально-економічних інтересів виробників сільськогосподарської продукції, суб’єктів логістики та торгово-посередницької ланки, споживачів (кінцевих та проміжного споживання) продукції сільського господарства, елементів ринкової інфраструктури та держави.