bluuebunny/crossref_metadata_2025 huggingface dataset:
THE EFFECT OF QUR'AN MUROTAL THERAPY ON INCREASING LEARNING CONCENTRATION IN SCHOOL AGE CHILDREN IN SINDANG PANON RESIDENCE HOUSING, TANGERANG REGENCY
Authors: Kusuma Gita Septiyani , Yuliani
Published: June 2022

Introduction: Concentration is a way of focusing the mind on something by putting aside other things that are not related. Students who concentrate on learning can be seen from some of their behavior during the teaching and learning process. Methods: This study uses a quantitative descriptive method using a quasi-experimental research design. Sampling in this study used a time series design, by comparing the post-test and pre-test scores with the number of respondents 30 school-age children who were in the Sindang Panon residence. Results: The results in the pre-test and post-test control groups obtained an average value of 102.07 with a standard deviation (pre-test) of 10.215 and (post-test) of 9.903. In the experimental group, the pre-test got an average value of 67.47 with a standard deviation of 9.862, the post-test got a value of 97.73 with a standard deviation of 13,541. In this study, a p value of 0.000 was obtained which can be concluded that there is an influence between learning concentration before and after being given murotal Qur'an therapy. Conclusions: In this study, it was explained that the administration of murotal Al-Qur'an therapy had an effect which was found in the experimental group of students who did not have a low level of concentration, as well as in the control group most of the students had a high level of concentration currently.
THE EFFECT OF HEALTH EDUCATION ON FAMILY'S ABILITY LEVEL IN GANGRENE WOUND CARE AT DIABETES MELLITUS PATIENTS IN TURI COMMUNITY HEALTH CENTERS, LAMONGAN
Authors: Umam Khotibul , Habibah Mita Nur , Lutfiandini Cherlys Tin , Medawati Riris
Published: June 2022

Introduction: Diabetes Mellitus causes neuropathy and abnormalities in blood vessels that cause changes in the skin and muscles, making it easier for gangrene to occur. Gangrene wounds that are left untreated or treated inappropriately can spread and increase the risk of amputation and death. Proper gangrene wound care is needed to speed up the healing process and prevent the wound from getting worse. Diabetes mellitus patients with wound gangrene need the help of other people (family) to carry out independent care at home. So that, the ability of the family to carry out proper care is needed. Methods: The design in this study used an analytical pre-experimental design with a one-group pre-test and post-test approach. The sampling of this study was total sampling used the Paired Sample T-Test. The population in this study was family who caring for family members with gangrene wounds at the Turi Community Health Center which met the inclusion criteria namely 25 respondents. Results: The results of this study showed that T = -3.361 means that there is an influence between the level of family ability in gangrene wound care before and after being given Health Education about Gangrene Wound Treatment. Conclusions: Health Education has a significant effect on the Family's Ability Level in gangrene wound care.
Development of higher education final judgment management information system using user-centered design method
Authors: Supriyadi Didi , Meiah Ngafidin Khairun Nisa , Lasama Jerry , Ramadhani Rafian
Published: June 2022

Final Judgment is a process of consideration to declare a student has met the academic and administrative requirements to hold a scholarship academic degree from the college. The Final Judgment management process business in universities involves many processes and stakeholders. Based on the result of observations and interviews, it is known that Final Judgment Management at the Informatics Faculty of ITTP is currently done manually by filling out the registration form and takes a long time for its processing. This study aims to develop Information Systems using User-Centered Design (UCD) methods that can meet the users' needs in implementing and managing Final Judgment processes. The developed system was tested for usability using a questionnaire to users with the Nielsen Attribute Usability (NAU) method. The method consists of five criteria, they are Learnability, Memorability, Efficiency, Errors, and Satisfaction. Usability test results showed: Learnability rate of 3.60, Memorability of 3.35, Efficiency of 3.90, Errors of 3.12, and Satisfaction of 3.63. Therefore, the average usability level of the Final Judgment system is 3.52. The user agrees that the developed Final Judgment information system has met the expected functional needs and is considered more effective and efficient.
Optimization of Mechanosensitive Cross-talk between Matrix Stiffness and Protein Density: Independent Matrix Properties Regulate Spreading Dynamics of Myocytes
Authors: Brock Judith , Erhardt Julia , Eisler Stephan A. , Hörning Marcel
Published: June 2022

Cells actively sense differences in topology, matrix elasticity and protein composition of the extracellular microenvironment and adapt their function and morphology. In this study, we focus on the cross-talk between matrix stiffness and protein coating density that regulate morphology and proliferation dynamics of single myocytes. For this, C2C12 myocytes were monitored on L-DOPA functionalized hydrogels of 22 different elasticity and fibronectin density compositions. Static images were recorded and statistically analyzed to determine morphological differences and to identify the optimized extracellular matrix (ECM). Using that information, selected ECMs were used to study the dynamics before and after cell proliferation by statistical comparison of distinct cell states. We observed a fibronectin density independent increase of the projected cell area until 12 kPa. Additionally, changes in the fibronectin density led to an area optimum at about 2.6 μg/cm, which was confirmed by an independent F-actin analysis, revealing a maximum actin filament to cell area ratio of 7.5 %. The proliferation evaluation showed an opposite correlation between cell spreading duration and speed to the matrix elasticity and protein density, which did not affect the cell cycle duration. In summary, we identified an optimized ECM composition, while independent matrix properties regulate distinct cell characteristics.
Assessing the Accuracy of Deformation Time Series Using an Automated InSAR Pipeline
Authors: Olsen Kelly M. , Calef Matthew T. , Agram Piyush S.
Published: June 2022

InSAR and associated analytic methods can measure surface deformation from low earth orbit with a claimed accuracy of centimeters to millimeters. The realized accuracy depends on the area being measured and on the choice of analytic method, suggesting one choose a method in response to the area being measured. Here we consider a specific fixed analytic method and compare the results it produces to measurements gathered from other means in a variety of settings. In particular we compare Sentinel-1 InSAR with GPS at the Kilauea volcano around the 2018 eruption, with GPS in the city of Arica, Chile, and with public survey data at a decommissioned tailings mine. In addition, we compare two independent Sentinel-1 InSAR analyses for a railway station in Oslo, Norway. Our goal is estimate the accuracy of a fully automated Sentinel-1 InSAR pipeline in various settings. Our conclusions are that centimeter level accuracy is a reasonable claim in many, but not all settings, and that accuracy is typically not lost by using an automated pipeline, instead of hand-selecting and tuning parameters.
Clinical Research in Ayurveda - Can Statistics as A Scientific Discipline Help the Cause?
Authors: Mahajan Vinay , Sanker MK Vivek , Mathur Aswhini
Published: June 2022

Ayurveda as a healthcare system has survived for thousands of years but continues to be dogged by reported lack of efficacy of the treatments in clinical trials. The reported lack of efficacy could be due to a real lack of efficacy (which then contradicts the survival of Ayurveda as a functional medical system enjoying considerable public patronage) or could be attributed to inadequacies in the efforts towards evidence generation or in a larger context the overall scientific conduct of research in Ayurveda. In an effort towards better evidence generation, there is an immediate need for standardizing the design, conduct and reporting of clinical trials of Ayurveda but it is a daunting task. For this effort to benefit the scientific endeavors of Ayurveda researchers, it should allow the researchers to be able to apply Ayurveda’s multi-component, individualized and inherently holistic approach. Statistical principles can benefit this effort. Statistical hypothesis testing (SHT) is central to these statistical principles and also aligns well with conventional scientific principles of evidence generation. Although there are challenges with SHT, good practitioners engaged in it do much more than just apply the mathematical theory behind it. As a particular example, lot of time in clinical trial designing is spent in addressing biases and designing trials prudently by minimizing the effect of such biases. SHT can benefit such an effort objectively. There is a need for Ayurveda researchers to engage deeply and mindfully about biases in study design in order to gain scientific validity and acceptability. The article highlights issues that arise in Ayurveda research, and discusses few ways of dealing with these issues using statistical principles.
Sustainable Consumption Pattern for Increased Food Security – Case Study Romania
Authors: Balan Ioana Mihaela , Gherman Emanuela Diana , Gherman Remus , Brad Ioan , Pascalau Raul , Popescu Gabriela , Trasca Teodor Ioan
Published: June 2022

Food security is a matter of global interest, as the provision of food resources is the primary determinant of human existence. Food is one of the basic needs, ensuring the survival of the species. The trend of globalization and development of the global economy has shifted the responsible local consumption patterns to an increased homogeneity of diets, food products being disconnected from their source. This disconnection led to two major results: (1) increased global consumption, with seasonal foods now available throughout the year, and a decrease in food prices on the global market, and (2) increased uncertainty in the supply chain, susceptible to disruptions, as was the case during the Covid-19 pandemic. The present study, based on the research and analysis of third-party data on food security, sustainable diets, consumption patterns and recommended actions to change the current unsustainable consumer behaviour towards a careful approach to food, environment and personal health, aims to identify consumption patterns that have the potential to increase the sustainability of the food system and a positive correlation with food security. Adopting sustainable dietary patters, based on short supply chains and mindful consumption, has great potential in restoring food security and resilience to adversity.
Development Book Based on Constructivism for Basic Education in Primary School Teacher Education Program
Authors: Mariyani Anna , Ula Wahyu Rikha Rofikhatul
Published: June 2022

The objectives of this research are: 1) to develop of book for basic education in the constructivism-based; (2) to investigate the feasibility of book for basic education in the constructivism-based; and (3) the effectiveness of book for basic education in the constructivism-based for the students’ achievement STKIP Muhammadiyah of Blora Central Java. The research used the Research and Development (R&D) method, which referred to the model claim by Thiagarajan (4D), namely: (1) Define; (2) Design; (3) Development; (4) Disseminate. The respondents of book for basic education included field testing respondents consisting 2 validators and 2 practitioners, limited scale main field testing respondents consisting 10 students, and operational field testing respondents consisting of 30 students in class existing learning. The data of research through questionnaire, observation, in-depth interview, and test. The data analysed by using the descriptive qualitative method.
The economic impact of digitalization and the creation of digital products on the development of the state
Authors:   Platinum Software Development Company, Dziatkovskii Anton , Hryneuski Uladzimir ,   Platinum Software Development Company, Dudov Aleksandr ,   Platinum Software Development Company, Krylova Aleksandra ,   Platinum Software Development Company
Published: June 2022

The main components of the development of the digital economy as the next stage in the formation of a modern model of the production, technological and social system of society based on the results of the Fourth Industrial Revolution are regulatory regulation, infrastructure, network security (cybersecurity), training of professionals and the formation of technological platforms. This is exactly what the function of the state in partnership with business should be aimed at, the implementation of which requires an appropriate investment policy. The government must continue to strengthen the digital foundations by attracting investment in scalable, smart, and secure infrastructure capable of accelerating the pace of digital development. When implementing an investment strategy, it is important to identify sources in the field of investment - public and private, whose shares should be regulated by a special program «Digital Economy» and pay attention not only to large businesses that are interested in developing all aspects of the digital economy but also to small investors who are mainly represented by Portfolio Investment. An important component is to encourage investment in digitalization. To do this, in the field of investment activity to ensure the support of investment projects, it is necessary to form general rules for creating and evaluating special investment regimes: a list of new approaches to obtaining tax benefits, reducing insurance premiums for both private investors and investment companies implementing various projects, the development of specific measures of state support in one of the following forms: providing benefits for project financing; provision of benefits for the payment of property tax and land tax; compensation of investor investments through various tax revenues from the investment project, stabilization of regulatory and tax conditions. Scientific novelty. The article examines the digital economy as an emerging phenomenon of the annual increase in the share of the world economy, in comparison with the raw materials and commodity part of it. The article considers the latest technologies and their impact on the traditional economy of various countries of the world. The purpose of the article is to study the basic principles of digitalization of the economy, which allow the digital economy to become a full-fledged part of the globalized world.
Agricultural market of the Republic of Kazakhstan: trends, problems and prospects for development
Authors:   Kostanay branch of Chelyabinsk State University, Mishulina Olga , Lilimberg Svetlana ,   Kostanay branch of Chelyabinsk State University, Panina Galina ,   Kostanay branch of Chelyabinsk State University, Baranova Natalya ,   Kostanay branch of Chelyabinsk State University, Zhaparov Temirlan ,   Kostanay branch of Chelyabinsk State University
Published: June 2022

We consider the main issues of the agricultural section development in the Republic of Kazakhstan. Current trends that are set in the agricultural market and possible solutions are presented, as well as the prospects for the development of the agricultural market. The article discusses the prospects of creating conditions for the production and sale of competitive goods in the agricultural sector of the Republic of Kazakhstan, the international experience in creating effective mechanisms for moving towards sustainable development of the society based on modern agriculture, the progress and employing of sustainable development indicators in the formation and selection of priorities, as well as the strategy for achieving them.
University website as an Internet marketing tool: a case study of Kazakhstan
Authors:   Almaty Management University, Abuova Ainel , Assanbayev Mukhit ,   Abai Kazakh National Pedagogical University, Assanbayeva Alua ,   Al-Farabi Kazakh National University, Kilybayev Talgat ,   Abai Kazakh National Pedagogical University, Basmurzin Talgat ,   Varna Free University
Published: June 2022

Today, more than ever, a university’s website is critical for the promotion of its mission, academic programs and services. Its communications with its target markets must be organized, professional and creative. A successfully created website design attracts visitors and, of course, should increase enrollment. A well-designed and clearly written university website will allow readers to receive all the needed and required information for them to make the proper decisions. Accordingly, research aimed at analyzing various issues of creating an effective university website is gaining significant relevance. The article discusses both the theoretical and practical issues of website activities. A selection of university websites has been analyzed and the issues and challenges discussed.
Risk management practices in the insurance industry with regard to supply chain management
Authors:   MIREA - Russian Technological University (RTU MIREA), Budovich Lidia
Published: June 2022

Today, fierce competition between manufacturers, increasing the level of innovation and reducing the life cycle of products have led to the design, production and marketing of products with various goals and a variety of risks in macro designs for supply chains. The purpose of this study is to design a strategic supply chain risk management system with a systematic approach to assess and control risks in the insurance industry. This article is an applied research and descriptive, correlational, and multiple regression analysis and path analysis techniques have been used to determine the factors affecting supply chain risk. This research is one-time cross-sectional taken place in 2021. The participant cases were 150, which resulted in 110 samples using Cochran’s sampling formula. Risk assessment and rating determines the superiority of each risk based on relevant indicators and thus provides the opportunity to provide an appropriate response to each risk. In this research, by presenting a comprehensive and hierarchical model for risk assessment, while identifying the main risks of the supply chain by relying on the method of risk failure structure and determining measurement criteria, a comprehensive questionnaire has been prepared based on the relative importance of each risk in the insurance industry. It has been determined as a case study using analytical method.
Objective and imperative meaning of financial policy at micro level
Authors:   Russian State University of Tourism and Service, Bokareva Elena , Silaeva Anna ,   Russian State University of Tourism and Service, Sanginova Lola ,   Financial University under the RF Government, Boboshko Vladimir ,   Moscow University of the RF Ministry of Internal Affairs, Boboshko Natalia ,   Moscow University of the RF Ministry of Internal Affairs
Published: June 2022

Nowadays, financial policy is a form of ideology and goal-setting implementation in the financial issues at any management levels (interstate formation, national economy, region, business entity, household), including the methods of financial resource mobilization, income, and expense structuring, legal regulations, assessing the impact of the controlled object on the economy. Financial policy is an enterprise goal-setting implementation concerning the micro-level (the level of business entities), including generating income and expenses, structuring, internal regulations, and assessments. The study aims to analyze the objective and imperative content of financial policy at the micro-level in the year 2020. With this purpose, we employ techniques and tools of economic and logical analysis, the methods of comparison, and groupings. We have made several proposals for policies to improve economic growth, including: avoidance of policies for economic cycles, especially in times of shock to macroeconomics, guide prices at the macroeconomic level, especially interest rates and exchange rates to support development goals, pursue trade and industrial policies to create increasingly profitable economic activities, Improve financial development and efficient and effective use of international relations.
Saliva Crystallization Features in Young People with Different Levels of Physical Activity
Authors: Martusevich Andrew K , Sinitsyna Tatyana P , Surovegina Alexandra V , Bocharin Ivan V , Kosyuga Svetlana Yu
Published: June 2022

The aim of the study was to estimate the features of dehydration structuring of saliva in untrained people. Methods and Results: The study included 35 untrained students (Group 1) and 38 people who regularly exercise (Group 2), who do not have any chronic diseases. The mean age of participants was 17-18 years. The crystallogenic activity and initiatory potential were evaluated for each sample of biological fluid. The crystallization of mixed saliva was studied using the method of classical crystalloscopy, and the initiating properties were studied by the method of comparative tezigraphy. A 0.9% sodium chloride solution was used as the base substance in the tezigraphic test. The conducted crystalloscopic studies have demonstrated significant differences in the crystallogenic and initiating properties of mixed saliva in people who regularly engage in physical training, compared with untrained individuals. They manifest themselves in a significant qualitative and quantitative transformation of the crystalloscopic picture of the biological fluid, including single-crystalline and dendritic components, as well as in the representation of amorphous bodies in micro-preparations of the biological medium. In the tezigraphic test, it was found that the initiatory potential of mixed saliva also undergoes significant shifts. These shifts are realized in the activation of the initiating ability of biological fluid and optimization of textural characteristics of tezigrams (reduction of cellular density and increase in uniformity) in combination with a decrease in the degree of destruction of structural picture elements and a moderate expansion of the marginal zone of micro-preparations.
Results of Evaluation of the Physical and Mechanical Properties of a New Suture Material with Miramistin Coating
Authors: Mosolova Anastasia V , Sukovatykh Boris S , Zatolokina Maria A , Mishina Ekaterina S , Tishkov Denis S , Sozykin Alexander A
Published: June 2022

Background: The imperfection of surgical sutures, from the point of view of insufficient prevention of microbial contamination in the area of suturing, is one of the urgent problems in modern practical healthcare. In this connection, one of the promising areas at the present time is the study of suture material under conditions of its coating with various antiseptics. This study aimed to evaluate the physical and mechanical properties of the suture material impregnated with miramistin for further application in experimental studies on animals. Methods and Results: By applying a two-layer polymer coating on absorbable polyglycolide threads, the threads were given antimicrobial properties. In the amount of 10% or 20% by weight of the polymer, miramistin was introduced into both coatings. The breaking load and elongation data in the surgical suture knot were evaluated by immersing the samples in a phosphate buffer solution (pH=7.4), maintaining a constant temperature of 37°C by a thermostat. Threads from the solution were extracted on Days 1, 3, 7, 14, and 21 of the experiment. Further, the studied samples of the suture material were subjected to stretching to rupture on a universal tensile testing machine of the domestic company Metrotest. Physical and mechanical properties were evaluated by the dynamics of the breaking load and elongation at a break in the node after being in a phosphate buffer solution. Coating of polyglycolide thread, which is a suture material, with miramistin at a concentration of 10% and 20% does not lead to loss of strength even in the long term of the experimental study, which, in turn, meets the standards for suture material. Conclusion: The results obtained allow us to recommend a suture material impregnated with miramistin for further research, the ultimate goal of which will be the possibility of active use of this material in practical medicine, in particular in surgery to prevent microbial contamination in the area of suturing and infection of wounds.
Optimizing intra-facility crowding in Wi-Fi environments using continuous-time Markov chains
Authors: Mizuno Shinya , Ohba Haruka
Published: June 2022

Recently, increased measures are being devised to reduce crowdedness as a countermeasure for the spread of COVID-19. In this study, we propose a solution to reduce intra-facility crowdedness based on the usage of Wifi networks. This study maximizes the Wi-Fi logs that are continually generated in vast quantities in the ever-expanding Wi-Fi network environment to calculate the transition probabilities between nodes and the mean stay time at each node. Then, we model this data as a continuous-time Markov chain to obtain the variance of the stationary distribution, which we use as a metric of intra-facility crowdedness. Therefore, to minimize intra-facility crowdedness, we solved the optimization problem using stay rate as a parameter and demonstrated a numerical solution. In the optimization results, we succeeded in reducing intra-facility crowding by approximately 30%. This solution is a realistic approach for reducing intra-facility crowdedness as it makes adjustments to people’s stay times without any changes in their movements. We used the k-means method to categorize Wi-Fi users into a set of classes and documented the behavioral characteristics of each class, which helped implement class-specific measures to reduce intra-facility crowdedness. This enables facility managers to implement fine-grained countermeasures against crowdedness according to circumstances. Herein, we describe our computing environment and workflow for the basic analysis of vast quantities of Wi-Fi logs. Because the data we used are general-purpose, we believe that this research will be useful for both analysts and facility operators.
The crop residue conundrum: maintaining long-term soil organic carbon stocks while reinforcing the bioeconomy, compatible endeavors?
Authors: Andrade Christhel , Clivot Hugues , Albers Ariane , Zamora-Ledezma Ezequiel , Hamelin Lorie
Published: June 2022

Crop residues are key for supplying renewable carbon to the bioeconomy without interfering with food security. However, residue removal represents a challenge for soil organic carbon (SOC) stocks maintenance. This study demonstrates that the crop residues potential for the bioeconomy is spatially differentiated and depends on the conversion technology and the available recalcitrant carbon return to soils. We considered coproduct returns from five bioeconomy pathways: pyrolysis, gasification, hydrothermal liquefaction, anaerobic digestion, and lignocellulosic ethanol. Long-term SOC changes from these scenarios were compared against a reference where crop residues are unharvested. We developed an original framework by coupling a SOC model with a bioeconomy module, applicable to any site. The framework was tested and applied to the entire France, for 2020 – 2120, simulating more than 60,000 cropland units. It revealed an additional crop residue potential of 60 – 191 PJ (use-dependent) without SOC decreases, compared to the often used 31.5% removal limit.
The effect of group reflection on the development of Communication Skills in undergraduate nursing students
Authors: Abadi Fozieh , Bagheri Maryam , Abadi Faezeh , pelarti akram mohammadi , karimi shahnaz
Published: June 2022

BACKGROUND
Communication skills are one of the main capabilities expected from nursing students and the core of nursing care. This study was conducted with the aimed of the effect of group reflection on the development of communication skills.
Methods
The study was a two-group quasi-experimental pre-test-post-test that was conducted at Fasa University of Medical Sciences in the south-west of Iran. The study population consisted of 48 second-semester nursing students enrolled in clinical fundamental of nursing course in February 2018. Group reflection based on Borton's Development Framework was used in learning communication skills to the test groups for 6 sessions. Conventional method was used for control groups.
Results
The mean score of communication skills among students in both control and test groups, before and after the group reflection sessions, indicated a significant difference (P < .0.001).
CONCLUSION
This study suggests that employing a reflection group can be a basis for developing students' communication skills in clinical education.
Establishing a multi-dimensional methodology to analyse pigments on sandstone sculptures: Exploratory investigations of an Antonine Wall Distance Sculpture
Authors: Campbell Louisa , Smith Margaret
Published: June 2022

The Antonine Wall was commissioned by the Roman Emperor Antoninus Pius around 142 CE and stretches for c. 37 miles across the central belt of Scotland, marking the Empire’s most north-western frontier. This vanguard research reports on the materials used during the 16th century in the redecoration of an iconic Distance Sculpture that was once embedded into the frontier. Portable non-invasive technologies, including pXRF and in-situ microphotography were deployed. These techniques are supplemented by micro-sampling for SEM/EDS, FTIR-ATR and microscopy of cross-sections.
Biorationals an important non chemical alternative to pesticides for management of two spotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae) on parthenocarpic cucumber grown under protected conditions
Authors: Ghongade Dilip Shriram , Sangha K.S.
Published: June 2022

The use of chemical pesticides to control two spotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae) in various crops leads to the development of various problems viz., residue in sprayed crop, pest resistance, pest resurgence and environmental pollution. It was necessary to find some microbial biorationals may represent an effective alternative management tactic which is environmentally safer option also. So, during this study entomopathogenic fungi (EPF) and botanical pesticides were tested at different concentrations for the management of eggs and active stages of T. urticae infesting parthenocarpic cucumber grown under polyhouse. Among these biorationals, spray of Neem Baan at 10 and 15 ml/l resulted in significantly higher level of reduction on two spotted spider mite population (88.5 to 91.8% in egg and 86.6 to 90.9% in active stage of mites after 3rd spray, respectively) than with EPF. Among the EPF, Lecanicillium lecanii (Zimmerman) Viegas and Beauveria bassiana Balsamo (Vuillemin) (at 10 & 15 ml/l (82.0 to 87.0% in egg and 79.2 to 84.1% in active stage of mites)) was found to be more effective than Metarhizium anisopliae (Metschnikoff) Sorokin (at 10 & 15 ml/l (77.0 to 82.4% in egg and 76.4 to 80.4% in active stage of mites after third spray, respectively)) in reducing different life stages of T. urticae on cucumber. Results suggest, as Neem Baan 1% spray was found to increase growth and yield of sprayed plant along with controlling T. urticae, it can act as a good alternative for the pesticide spray because spray of pesticide majority time leads to residue problem, pest resistance and pest resurgence problem.
Anticancer activities of Saudi Juniperus procera extracts and their effects on the regulatory mechanisms in controlling growth of human cancerous cells
Authors: Al-Zahrani Ateeq , Ibraheem Farag , El-Senduny Fardous F.
Published: June 2022

Cancer is one of the most distributed diseases in the world, which has been associated with a high number of mortalities compared to other diseases. Compared to traditional cancer treatment methods such as chemotherapy and radiotherapy, anti-cancer medicinal plants are mor safer due to their minimum side effects. The Juniperus procera plant is one of medicinal plants used in traditional Saudi medicine, and its extract is used to treat many diseases including cancer. In this study, we investigated the anticancer impacts of J. procera extracts and their potential anticancer activities on breast, ovarian and liver cancers with the focus on the first type. Phytochemical analysis revealed that the fruit extract had higher amount of total phenolics while the leaf extract was richer in flavonoids. The fruit extract showed more antioxidant and cytotoxicity activities against breast, ovarian, and liver cancers. MCF-7 and MDA-MB-231, breast cancer cell lines were further investigated using the fruit extract. Both cell lines were arrested in S phase and G1 phase, respectively. Nuclear fragmentations and apoptosis were triggered in both cell lines. ROS was increased and the cell migration was inhibited. PI3K/Akt/mTOR pathway was down regulated. Aromatase gene expression was decreased in MCF-7 and increased in MDA-MB-231. Both extracts were selective toward cancer cells rather than the normal cells (SI > 2). Fruit and leaf extracts have significant antitumor activities, and such activity was more pronounced in the fruit extract than leaf extract. This study highlights the importance of J. procera leaf and fruit as an anti-cancer.
The Relationship Between Menopausal Syndrome and Gut Microbes
Authors: Liu Yaqian , Zhou Ying , Huang Yanmei , Liang Jingtao , Zhu Min , Yao Peixun , Zong Yun , Lang Jianying , Zhang Yingxuan
Published: June 2022

Purpose
The association between gut microbes dysbiosis and menopause syndrome (MPS) is poorly understood. The aim of this study was to explore the relationship between MPS and gut microbes.
Methods
77 MPS patients (P group) and 24 menopausal healthy women (H group) were recruited in this study. Participants were collected their stool specimen and clinical parameters (including demographic data, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), et al ). We looked at the differences in gut microbiota between two groups by 16S ribosomal RNA gene sequencing. LEfSe was used to identify bacteria with varying abundances in different groups. Clinical parameters and microbial species Spearman correlation coefficients were calculated. PICRUSt was used to predict the potential KEGG Ortholog functional profiles of microbial communities.
Results
The abundance of 14 species differed substantially between the MPS and menopausal healthy women (LDA significance threshold > 2.0) according to LEfSe analysis. Using Spearman's correlation analysis, it was discovered that Aggregatibacter segnis, Bifidobacterium animalis, Acinetobacter guillouiae were enriched in menopausal healthy women, with a positive correlation with the E2 and a negative correlation with the FSH and LH (p ༜ 0.05); the abundances of species had a close correlation with the other clinical parameters, including the KI score, hot flash, et al. KEGG L3 metabolic pathways relevant to cardiovascular disease and carbohydrate metabolism were also enriched in the MPS (p ༜ 0.05), according to functional prediction by PICRUST and analyzed by Dunn test.
Conclusion
There were gut microbes dysbiosis in MPS, which is reflected in the deficiency of the abundance of Aggregatibacter segnis, Bifidobacterium animalis and Acinetobacter guillouiae related to the level of sex hormones. In MPS individuals, species with altered abundances and unique functional pathways were found.
Development of a program to determine optimal settings for robotic-assisted rehabilitation of the post-stroke paretic upper extremity: a simulation study
Authors: Takebayashi Takashi , Uchiyama Yuki , Okita Yuho , Domen Kazuhisa
Published: June 2022

Background: Robot-assisted therapy can effectively treat upper extremity (UE) paralysis in patients who experience stroke. Presently, UE, as a training item, is selected according to the severity of the paralysis, which is based on a clinician’s experience. The possibility of objectively selecting robot-assisted training items based on the severity of paralysis was simulated using the item response theory (IRT).Methods: Sample data were generated using Monte Carlo method with 300 random cases. In this simulation, sample data (categorical data with three difficulty values of 0, 1, and 2 [0: too easy, 1: adequate, and 2: too difficult]) with 71 items per case were analyzed. First, the most appropriate method was selected to ensure local independence of the sample data necessary to use IRT. The method was to exclude: items with low response probability (maximum response probability) within a pair in the Quality of Compensatory Movement Score (QCM) 1-point item difficulty curve, items with low item information content within a pair in the QCM 1-point item difficulty curve, and items with low item discrimination. Second, 300 cases were analyzed to determine the most appropriate model (one-parameter or two-parameter item response therapy) to be used and the most favored method to establish local independence. We also examined whether robotic training items could be selected according to the severity of paralysis based on the ability of the person (θ) in the sample data as calculated by IRT.Results: To ensure local independence, excluding items with low response probability (maximum response probability) in a pair in the categorical data 1-point item difficulty curve was effective.Additionally, to ensure local independence, the number of items should be reduced to 61 from 71, indicating that the two-parameter model IRT was an appropriate model. The ability of the person (θ) calculated by IRT suggested that seven training items could be estimated from 300 cases according to severity.Conclusion: From this simulation, it seemed possible to objectively estimate the training items according to the severity of paralysis in a sample of approximately 300 cases using this model.
Differences of professionalism perception on social networking sites between doctors of medicine and dental medicine: Development of e-professionalism assessment compatibility index (ePACI)
Authors: Viskić Joško , Marelić Marko , Poplašen Lovela Machala , Rukavina Tea Vukušić
Published: June 2022

Background:Social networking sites (SNS) have penetrated all aspects of our professional and private life. A new term e-professionalism has emerged which combines traditional values with this new dynamic online environment for health care professionals. Medicine and dental medicine are similar, yet diverging professions. SNS offer valuable tools to reach out to patients on an educational and promotional level for both professions, but bring many dangers to professionalism. The aim of this study was to examine the SNS prevalence, usage habits, and perception of e-professionalism of medical doctors (MDs) and doctors of dental medicine (DMDs) in Croatia. Additionally, to develop an e-professionalism assessment compatibility index (ePACI) and explore differences and shifts in index values of these groups.Methods:A quantitative cross-sectional study on the use of SNS and attitudes about e-professionalism of MDs and DMDs was conducted via email to all MDs and DMDs members of respective chambers. Using the SMePROF rubric for assessment of unprofessional content on Facebook principal component analysis was conducted. ePACI was designed to measure not only perception in line with the expected answer, but also the direction of the shift.Results:Of the 1013 gathered responses, 753 were valid SNS users for further analysis. Facebook (91.6%) and Instagram (63.1%) were the predominant SNS used. Both groups have a good understanding of e-professionalism, however, DMDs are less sensitive to view visual depictions of patients on SNS (χ21=32.119, p<0.001), and endorsements from pharmaceutical companies without conflict-of-interest disclosure (χ21=19.354, p<0.001) as unprofessional.The newly developed ePACI shifts lightly to the conservative side for both for MDs (t=19.033, df=506, p<0.001) and DMDs (t=12.991, df=245, p<0.001). Statistically significantly more conservative ePACI values have health care professionals who are older (r=0.308, p<0.001), who have fewer SNS profiles (rs= -0.142, p<0.001), and who access their profiles less frequently (r= -0.166, p<0.001).Conclusions:MDs and DMDs are heavy SNS users and have an understanding of e-professionalism. The development of the ePACI and subsequent usage in further research, has a direct influence in gathering comparable data and can steer on where efforts in oversight, regulation and education should be pointed.
Seven pediatric Cases with Familial hypomagnesemia with hypercalciuria and nephrocalcinosis
Authors: Aydın Zehra , Cayci Fatma Semsa , Inozu Mihriban , Sahin Ibrahim , Konrad Martin , Bayrakci Umut Selda
Published: June 2022

Purpose: Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare autosomal-recessive renal tubular disorder. FHHNC is characterized by renal wasting of magnesium (Mg) and calcium (Ca), which subsequently leads to bilateral nephrocalcinosis, renal stones, and chronic renal failure. Here, we report seven patients with FHHNC. Methods: We retrospectively analyzed pediatric cases of FHHNC between 2010-2020. Results: A total of 7 patients, 5 girls (71.4 %) and 2 boys (28.5 %) with a median age of 4 years (min:4 months, max:13 years) and a mean follow-up time of 4.4±3.5 years were included. 3 patients had been diagnosed incidentally. All of the patients had nephrocalcinosis, hypercalciuria and high PTH level. One patient had hypocalcemia and one patient had normal serum magnesium level. All patients had high urine FEMg. Five patients had CLDN 16 mutation, and two patients had CLDN19 mutation. None of them had ocular findings. Three patients had chronic renal failure at the end of the follow-up.Conclusions: We want to draw attention to the FHHNC in children with nephrocalcinosis. FHHNC should be considered in children with normal serum magnesium levels since a normal serum magnesium level does not rule out FHHNC, and high FEMg levels are more significant for the diagnosis.
Relationship between the diffusing capacity of the lung for carbon monoxide (DLCO) and lung adenocarcinoma patterns: new possible insights
Authors: Ventura Luigi , Gnetti Letizia , Milanese Gianluca , Rossi Maurizio , Leo Ludovica , Cattadori Sara , Silva Mario , Leonetti Alessandro , Minari Roberta , Bocchialini Giovanni , Silini Enrico Maria , Tiseo Marcello , Sverzellati Nicola , Carbognani Paolo
Published: June 2022

PURPOSE: This study aimed to evaluate a potential relationship between the diffusing capacity of the lung for carbon monoxide(DLCO) and the aggressiveness of lung adenocarcinoma(ADC).METHODS: Patients who underwent radical surgery for lung ADC between 2001 and 2018 were retrospectively reviewed. DLCO values were dichotomized into DLCOlow(<80% of predicted) and DLCOnormal(≥80%).Relationships between DLCO and ADC histopathological features, clinical features, as well as with overall survival (OS), were evaluated. RESULTS: Four hundred and sixty patients were enrolled, of which 193(42%) were included in the DLCOlow group. DLCOlow was associated with smoking status, low FEV1, micropapillary and solid ADC, tumour grade 3,high tumour lymphoid infiltrate and presence of tumour desmoplasia. In addition, DLCO values were higher in low-grade ADC and progressively decreased in intermediate and high-grade ADC(p=0.024). After adjusting for clinical variables, at multivariable logistic regression analysis, DLCOlow still showed a significant correlation with high lymphoid infiltrate(p=0.017), presence of desmoplasia(p=0.065), tumour grade 3(p=0.062),micropapillary and solid ADC subtypes(p=0.008).To exclude the association between non-smokers and well-differentiated ADC, the relationship between DLCO and histopathological ADC patterns was confirmed in the subset of 377 former and current smokers(p=0.021).At univariate analysis, gender, DLCO, FEV1, ADC histotype, tumor grade, stage, pleural invasion, tumour necrosis, tumour desmoplasia, lymphatic and blood invasion were significantly related with OS. At multivariate analysis, only gender(p<0.001), tumour stage(p<0.001) and DLCO(p=0.050) were significantly related with the OS. CONCLUSIONS: We found a relationship between DLCO and ADC patterns as well as with tumour grade, tumour lymphoid infiltrate and desmoplasia, suggesting that lung damage may be associated with tumour aggressiveness.
Role of umbilical cord blood procalcitonin in the noninvasive diagnosis of fetal inflammatory response syndrome: a pilot study
Authors: Cui Xuewei , Shi Yongyan , Sun Tong , Fu Jianhua
Published: June 2022

Purpose: To evaluate the diagnostic effect of umbilical cord blood procalcitonin (PCT) on fetal inflammatory response syndrome (FIRS). Methods: This prospective study assessed preterm infants (100 with FIRS and 124 controls) with gestational age <32 weeks. The groups were compared in terms of the incidence of complications associated with preterm birth. To identify whether FIRS was an independent risk factor for complications of preterm birth, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by multivariable logistic regression models. Finally, we clarified the diagnostic efficiency by receiver operating characteristic curves. Results: Univariate analysis showed that the incidence of natural delivery, premature rupture of membranes (PROM) > 18h, antenatal antibiotic usage, chorioamnionitis, umbilical cord blood PCT, gestational age (GA), small for gestational age (SGA), bronchopulmonary dysplasia (BPD), early-onset sepsis (EOS), necrotizing enterocolitis (NEC), white matter injury (WMI), retinopathy of prematurity (ROP), and mortality were higher in the case group than the control group (p < 0.05). Multivariable analysis confirmed a significant association between FIRS and complications of preterm birth. The level of umbilical cord blood PCT of preterm infants could be used as a noninvasive diagnostic index for FIRS (cut-off value: 0.276 ng/ml). Conclusions: Umbilical cord blood PCT may be a reliable noninvasive diagnostic biomarker for FIRS. Chorioamnionitis, natural delivery, and the level of umbilical cord blood PCT are independent risk factors for FIRS in preterm infants, while GA was a protective factor for FIRS. FIRS is an independent risk factor for BPD, EOS, NEC, WMI and ROP.
Trends in adherence to recommended physical activity and its effects on cardiovascular risk factors in US adults with cardiovascular disease: a cross-sectional study
Authors: Cheng Yuhong , Mou Lin , Li Zhiliang
Published: June 2022

Background: Being physically active is important for cardiovascular health. This study aimed to examine the trend in adherence to the Physical Activity Guidelines (PAG) for aerobic activity among US adults with a history of cardiovascular disease (CVD) and quantified its association with cardiovascular risk factors.Methods: We studied participants from the National Health and Nutrition Examination Survey 2007-08 to 2017-18. Regression models were used to evaluate the significance of the trend and the association between adherence to the PAG with cardiovascular risk factors.Results: A total of 3638 participants were reported to have a history of CVD. The proportion of adherence to PAG significantly increased from 41.5% in 2007-08 to 54.3% in 2017-18. Male had a higher proportion of adherence compared to the female, while the trend in adherence was only significant in females. Adherence to the PAG was significantly associated with decreased levels of waist circumference, body mass index, hemoglobin A1c, and triglycerides.Conclusions: There is a significant increase in the proportion of adherence to the PAG among US adults with a history of CVD from 2007-08 to 2017-18, and adherence to the PAG was associated with better cardiovascular health.