Acceptability of oral liquid pharmaceutical products in older adults: palatability and swallowability issues
Authors: Belissa Emilie , Vallet Thibault , Laribe-Caget Sandra , Chevallier Alain , Chedhomme François-Xavier , Abdallah Fattima , Bachalat Nathalie , Belbachir Sid-Ahmed , Boulaich Imad , Bloch Vanessa , Delahaye Anne , Depoisson Mathieu , Wojcicki Amélie Dufaÿ , Gibaud Stéphane , Grancher Anne-Sophie , Guinot Caroline , Lachuer Celia , Lechowski Laurent , Leglise Patrick , Mahiou Abdel , Meaume Sylvie , Michel Corinne , Michelon Hugues , Orven Yann , Perquy Ines , Piccoli Matthieu , Rabus Maïté , Ribemont Annie-Claude , Rwabihama Jean-Paul , Trouvin Jean-Hugues , Ruiz Fabrice , Boudy Vincent 
Published: December 2019

Background

In institutional care, oral liquid pharmaceutical products are widely prescribed for older patients, especially for those with swallowing disorders. As medicines acceptability is a key factor for compliance in the older population, this study investigated the acceptability of oral liquid pharmaceutical products in this targeted population.

Methods

An observational, multicenter, prospective study was conducted in eight geriatric hospitals and eight nursing homes in France. Observers reported several behaviours/events describing the many aspects of acceptability for various pharmaceutical products’ uses in patients aged 65 and older. Acceptability scores of oral liquid pharmaceutical products were obtained using an acceptability reference framework (CAST - ClinSearch Acceptability Score Test®): a 3D-map summarizing the different users’ behaviors, with two clusters defining the positively and negatively accepted profiles materialized by the green and red zones, respectively.

Results

Among 1288 patients included in the core study and supporting the acceptability reference framework, 340 assessments were related to the administration of an oral liquid pharmaceutical product. The mean age of these patients was 87 (Range [66-104y]; SD = 6.7), 68% were women and 16% had swallowing disorders. Globally, the oral liquid pharmaceutical products were classified as “positively accepted,” the barycenter of the 340 assessments, along with the entire confidence ellipses surrounding it, were positioned on the green zone of the map. Sub-populations presenting a different acceptability profile have also been identified. For patients with swallowing disorders, the oral liquid pharmaceutical products were classified as “negatively accepted,” the barycenter of the 53 assessments along with 87% of its confidence ellipses were associated with this profile. A gender difference was observed for unflavored oral liquids. In women, they were classified “negatively accepted,” the barycenter of the 68 assessments with 75% of its confidence ellipses were located in the red zone, while they were classified “positively accepted” in men.

Conclusion

This study showed that oral liquid pharmaceutical products are a suboptimal alternative to solid oral dosage forms in patients with swallowing disorders. To ensure an optimal acceptability, prescribers should also consider the presence of a taste-masker in these oral liquids. As highlighted herein, palatability remains crucial in older populations, especially for women.