bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Perspectives in Radioactive Iodine Theranostics: Current Redifferentiation Protocols for Mis-Differentiated Thyroid Cancer
Authors: Gulec Seza A. , Benites Cristina , Cabanillas Maria E.
Published: June 2024

Thyroid cancer molecular oncogenesis involves functional dedifferentiation. The initiating genomic alterations primarily affect the MAPK pathway signal transduction and generate an enhanced ERK output, which in turn results in suppression of the expression of transcription of the molecules of iodine metabolomics. The clinical end result of these molecular alterations is an attenuation in theranostic power of radioactive iodine (RAI). The utilization of RAI in systemic therapy of metastatic disease requires restoration of the functional differentiation. This concept has been accomplished by modulation of MAPK signaling. Objective responses have been demonstrated in metastatic disease settings. RAI-refractoriness in “differentiated thyroid cancers” remains a clinical problem despite optimized RAI administration protocols. Functional mis-differentiation and associated RAI-indifference are the underlying primary obstacles. MAPK pathway modulation offers a potential for reversal of RAI-indifference and combat refractoriness. This review presents the latest clinical experience and protocols for the redifferentiation of radioiodine-refractory mis-differentiated thyroid cancer, providing a comprehensive overview of the current protocols and intervention strategies used by leading institutions. Timing and techniques of imaging, thyrotropin (TSH) stimulation methods, and redifferentiation agents are presented. The efficacy and limitations of various approaches are discussed, providing an overview of the advantages and disadvantages associated with each of the protocols.
Introduction to a New Open Access Journal by MDPI: Journal of Dementia and Alzheimer’s Disease
Authors: Tsolaki Magda
Published: June 2024

We are delighted to introduce a new journal dedicated to exploring various forms of dementia, with a specific focus on Alzheimer’s disease [...]
Pulsatile Ventilation Flow in Polychaete Alitta succinea Burrows
Authors: Murphy Elizabeth A. K. , Reidenbach Matthew A.
Published: June 2024

In aquatic sediments, active ventilation of burrows is an important component of sediment metabolism, transporting solutes across the sediment–water interface. Within a burrow, the temporal and spatial structure of the flow velocity can dictate the flux of solutes across the burrow walls. However, it is difficult to measure the fine-scale flow dynamics within a burrow due to the opacity of marine sediments. Here, we allowed a nereid polychaete Alitta succinea, a cosmopolitan deposit feeder found in brackish to marine soft sediments, to construct burrows in a transparent, elastic sediment analog. This allowed the measurement of the temporal velocity structure of flow in the burrow using particle tracking velocimetry. We find that the flow within the burrow of this piston-pumping polychaete is unsteady and that oscillations in flow velocity are damped with distance along the tube. We also show that the flow velocity in a tube scales with worm size. Conversely, neither the unsteadiness of flow oscillations nor the stroke frequency of the worm pump scale with worm size.
The Wave Amplification Mechanism of Resonant Caisson
Authors: Hao Jiawei , Ding Dietao , Li Jiawen , Huang Ji
Published: June 2024

Previous studies have introduced a resonant caisson designed to enhance wave energy extraction in regions with low wave energy density; however, its operational mechanism remains poorly understood. This paper seeks to elucidate the operational mechanism of the resonant caisson by leveraging Star-CCM+ for Computational Fluid Dynamics (CFD) simulations, focusing on the influence of guides and their dimensions on the water levels, flow velocities, and vortex dynamics. The findings demonstrate the remarkable wave-amplification capabilities of the resonant caisson, with the maximum amplification factor reaching 2.31 at the calculated frequency in the absence of guides. Incorporating guides and expanding their radii substantially elevate the flow rates, accelerate the water currents, and alter the vortex patterns, thereby further enhancing the amplification factor. This study will provide a reference for optimizing the design of resonant caissons and wave energy converters based on resonant caissons, thus promoting the effective use of wave energy resources.
Research and Application of Panoramic Visual Perception-Assisted Navigation Technology for Ships
Authors: Wang Chiming , Cai Xiaocong , Li Yanan , Zhai Runxuan , Wu Rongjiong , Zhu Shunzhi , Guan Liangqing , Luo Zhiqiang , Zhang Shengchao , Zhang Jianfeng
Published: June 2024

In response to challenges such as narrow visibility for ship navigators, limited field of view from a single camera, and complex maritime environments, this study proposes panoramic visual perception-assisted navigation technology. The approach includes introducing a region-of-interest search method based on SSIM and an elliptical weighted fusion method, culminating in the development of the ship panoramic visual stitching algorithm SSIM-EW. Additionally, the YOLOv8s model is improved by increasing the size of the detection head, introducing GhostNet, and replacing the regression loss function with the WIoU loss function, and a perception model yolov8-SGW for sea target detection is proposed. The experimental results demonstrate that the SSIM-EW algorithm achieves the highest PSNR indicator of 25.736, which can effectively reduce the stitching traces and significantly improve the stitching quality of panoramic images. Compared to the baseline model, the YOLOv8-SGW model shows improvements in the P, R, and mAP50 of 1.5%, 4.3%, and 2.3%, respectively, its mAP50 is significantly higher than that of other target detection models, and the detection ability of small targets at sea has been significantly improved. Implementing these algorithms in tugboat operations at ports enhances the fields of view of navigators, allowing for the identification of targets missed by AISs and radar systems, thus ensuring operational safety and advancing the level of vessel intelligence.
Revealing Brownish Mycena Diversity in China: New Discoveries and Taxonomic Insights
Authors: Wei Renxiu , Ge Yupeng , Qi Liangliang , Han Menghui , Zeng Hui , Hu Yaping , Zou Li , Cheng Xianhao , Wu Xiaoming , Na Qin
Published: June 2024

Within the genus Mycena, species exhibiting brownish basidiomata present considerable challenges in identification due to similar coloration. This study underscores the significance of pileipellis types and cheilocystidia characteristics as critical in delimiting brownish Mycena species. To clarify the principal taxonomic characters and their utility in distinguishing between brownish Mycena species, a morphological taxonomy and phylogenetic analysis were performed. Five new species from China were introduced and characterized through a comprehensive morphological anatomy and phylogenetic substantiation: M. campanulatihemisphaerica sp. nov., M. digitifurcata sp. nov., M. kunyuensis sp. nov., M. limitis sp. nov., and M. oryzifluens sp. nov. Discussions of these taxa are supplemented with morphological illustrations. The phylogenetic relationships were inferred using Bayesian Inference and Maximum Likelihood methods based on sequences from the internal transcribed spacer and the large subunit regions of nuclear ribosomal RNA. With the addition of these five new species, the worldwide count of brownish Mycena increases to 94, and a key to the 29 known species of brownish Mycena from China is presented.
Anatomical Reference of the Femur after Distal Resection Is Reliable for Rotational Alignment in Total Knee Arthroplasty
Authors: Kim Seong Hwan , Park Yong-Beom , Choi Gil-Won , Lee Han-Jun
Published: June 2024

The rotational alignment of the femoral component in total knee arthroplasty (TKA) is considered an important factor, but it is still difficult to assess intraoperatively. This study was conducted to identify anatomical parameters for femoral rotational alignment. A total of 204 patients who underwent primary TKA between 2015 and 2019 were enrolled. The femoral lateral (FLAP) and femoral medial anteroposterior (FMAP) lengths were measured as the widest lengths in the anteroposterior (AP) axis after distal femoral resection. The difference between FLAP and FMAP was defined as dFAP. The concordance correlation coefficient (CCC) was assessed for agreement between the cTEA-PCA and the value of femoral rotation using the linear regression analysis equation. HKA, FLAP, FMAP, and dFAP were significantly associated with femoral rotational alignment. The prediction equation combining the novel intraoperative anatomical references showed improved association with rotational alignment. If dFAP was 6.0 mm, the femoral rotation angle was calculated as 4.9° using this univariate regression equation. The CCC was 0.483, indicating moderate agreement. The dFAP showed an association with distal femoral rotational alignment. A 6 mm dFAP could be a reference for around 5° of femoral rotation. The equation developed in this study may be a reliable tool for intraoperative distal femoral rotational alignment.
Genetic Variation in ABCB1, ADRB1, CYP3A4, CYP3A5, NEDD4L and NR3C2 Confers Differential Susceptibility to Resistant Hypertension among South Africans
Authors: Katsukunya Jonathan N. , Jones Erika , Soko Nyarai D. , Blom Dirk , Sinxadi Phumla , Rayner Brian , Dandara Collet
Published: June 2024

Resistant hypertension (RHTN) prevalence ranges from 4 to 19% in Africa. There is a paucity of data on the role of genetic variation on RHTN among Africans. We set out to investigate the role of polymorphisms in ABCB1, ADRB1, CYP3A4, CYP3A5, NEDD4L, and NR3C2, on RHTN susceptibility among South Africans. Using a retrospective matched case–control study, 190 RHTN patients (cases: blood pressure (BP) ≥ 140/90 mmHg on ≥3 anti-hypertensives or BP < 140/90 mmHg on >3 anti-hypertensives) and 189 non-RHTN patients (controls: <3 anti-hypertensives, BP < 140/90 or ≥140/90 mmHg), 12 single nucleotide polymorphisms were genotyped using polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP), quantitative PCR and Sanger sequencing. Genetic association analyses were conducted using the additive model and multivariable logistic regression. Homozygosity for CYP3A5 rs776746C/C genotype (p = 0.02; OR: 0.44; CI: 0.22–0.89) was associated with reduced risk for RHTN. Homozygous ADRB1 rs1801252G/G (p = 0.02; OR: 3.30; CI: 1.17–10.03) and NEDD4L rs4149601A/A genotypes (p = 0.001; OR: 3.82; CI: 1.67–9.07) were associated with increased risk for RHTN. Carriers of the of ADRB1 rs1801252—rs1801253 G–C haplotype had 2.83-fold odds of presenting with RHTN (p = 0.04; OR: 2.83; CI: 1.05–8.20). These variants that are associated with RHTN may have clinical utility in the selection of antihypertensive drugs in our population.
Is an Elevated Preoperative CRP Level a Predictive Factor for Wound Healing Disorders following Lumbar Spine Surgery?
Authors: Pinchuk Anatoli , Luchtmann Michael , Neyazi Belal , Dumitru Claudia A. , Stein Klaus Peter , Sandalcioglu Ibrahim Erol , Rashidi Ali
Published: June 2024

Postoperative wound infections are a prevalent concern among the hospital-associated infections in Europe, leading to prolonged hospital stays, increased morbidity and mortality, and substantial patient burdens. Addressing the root causes of this complication is crucial, especially given the rising number of spine surgeries due to aging populations. Methods: A retrospective analysis was conducted on a cohort of 3019 patients who underwent lumbar spine surgery over a decade in our department. The study aimed to assess the predictors of wound healing disorders, focusing on laboratory values, particularly inflammatory parameters. Results: Of the 3019 patients, 2.5% (N = 74) experienced deep or superficial wound healing disorders, showing the significant correlation between C-reactive protein (CRP) levels and these disorders (p = 0.004). A multivariate analysis identified several factors, including age, sex, hypertension, diabetes, cardiac comorbidity, surgical duration, dural injury, and blood loss, as being correlated with wound healing disorders. Conclusion: Demographic factors, pre-existing conditions, and perioperative variables play a role in the occurrence of adverse effects related to wound healing disorders. Elevated CRP levels serve as an indicator of increased infection risk, though they are not a definitive diagnostic tool for wound healing disorders.
Precision Workforce Management for Radiographers: Monitoring and Managing Competences with an Automatic Tool
Authors: Lastrucci Andrea , Wandael Yannick , Orlandi Giovanni , Barra Angelo , Chiti Stefano , Gigli Valentina , Marletta Massimo , Pelliccia Davide , Tonietti Barbara , Ricci Renzo , Giansanti Daniele
Published: June 2024

Optimizing work shifts in healthcare is crucial for maintaining high standards of service delivery and fostering professional development. This study delves into the emerging field of skill-oriented work shift optimization, focusing specifically on radiographers within the healthcare sector. Through the development of Skills Retention Monitoring (SRH), this research aims to enhance skill monitoring, workload management, and organizational performance. In this study, several key highlights emerged: (a) Introduction of the SRH tool: The SRH tool represents a resource-efficient solution that harnesses existing software infrastructure. A preliminary version, focusing on the radiographers’ professional profile, was released, and after several months of use, it demonstrated effectiveness in optimizing work based on competency monitoring. (b) The SRH tool has thus demonstrated the capacity to generate actionable insights in the organizational context of radiographers. By generating weekly reports, the SRH tool streamlines activity management and optimizes resource allocation within healthcare settings. (c) Application of a Computer-Assisted Web Interviewing (CAWI) tool for pre-release feedback during a training event. (d) Strategic importance of a maintenance and monitoring plan: This plan, rooted in a continuous quality improvement approach and key performance indicators, ensures the sustained effectiveness of the SRH tool. (e) Strategic importance of a transfer plan: Involving professional associations and employing targeted questionnaires, this plan ensures the customization of the tool from the perspective of each profession involved. This is a crucial point, as it will enable the release of tool versions tailored to various professions operating within the hospital sector. As a side result, the tool could allow for a more tailored and personalized medicine both by connecting the insights gathered through the SRH tool with the right competencies for healthcare professionals and with individual patient data. This integration could lead to better-informed decision making, optimizing treatment strategies based on both patient needs and the specific expertise of the healthcare provider. Future directions include deploying the SRH tool within the Pisa hospital network and exploring integration with AI algorithms for further optimization. Overall, this research contributes to advancing work shift optimization strategies and promoting excellence in healthcare service delivery.
Clinical and Molecular Traits of a Novel SPECC1L-ALK Fusion in a Patient with Advanced Non-Small Cell Lung Cancer
Authors: Centonza Antonella , Mazza Tommaso , Trombetta Domenico , Sparaneo Angelo , Petrizzelli Francesco , Castellana Stefano , Centra Flavia , Fabrizio Federico Pio , Di Micco Concetta Martina , Benso Federica , Tabbò Fabrizio , Righi Luisella , Merlini Alessandra , Graziano Paolo , Muscarella Lucia Anna
Published: June 2024

Anaplastic lymphoma kinase (ALK) fusions account for 5–7% of non-small cell lung cancer (NSCLC) patients, the therapeutic approaches for which have significantly evolved in the last few years. However, the response to target therapies remains heterogeneous, partially due to the many different ALK fusion variants reported to date. Rare fusion variants have also been discovered, but their role in influencing responses to ALK inhibitors (ALKis) remains poorly elucidated. Laboratory investigation at both the tissue and protein levels, and a molecular profile by next-generation sequencing (NGS) were performed on a lung biopsy sample from one patient with poorly differentiated adenocarcinoma. An in silico prediction model using ColabFold software v1.5.5 was used to model and predict the entire structure of the chimeric aberrant ALK protein. Here, we report a case of a former smoker, a 60-year-old man, diagnosed with NSCLC and undergoing ALK translocation. He received first-, second- and third-generation ALK protein inhibitors (ALKis), showing a clinical benefit for about 4 years. IHC analysis and the molecular examination of the tissue biopsy indicated a positive staining for ALK and a novel ALK gene fusion variant, involving the sperm antigen with calponin homology and coiled-coil domain 1-like (SPECC1L) gene with an unreported breakpoint in exon 7. The novel SPECCL1::ALK fusion was identified using Anchored Multiplex PCR (AMP)-NGS technology and was predicted to retain the Pkinase_Tyr domain at the carboxy-terminal region of the resulting chimeric protein. To the best of our knowledge, this is the first case of an ALK-positive NSCLC patient carrying the SPECC1L exon 7 fusion breakpoint and one of the few reports about clinical outcomes related to SPECC1L::ALK fusion. The in silico hypothesized biological role of this newly identified fusion variant corroborates the observed clinical response to multiple ALKis. The molecular findings also reinforce the utility of AMP-based NGS technology as a valuable tool for the identification of rare chromosomal events that may be related to the variability of patient outcomes to different ALKis treatments.
Capital Structure and Financial Performance of Moroccan Agricultural Small- and Medium-Sized Enterprises: Moderating Effects of Government Subsidies
Authors: Nassim Imad , Benraïss Bouchra
Published: June 2024

In the context of implementing the new agricultural strategy, “Generation Green 2020–2030”, Moroccan agricultural SMEs are benefiting from specific lines of credit and significant financial incentives. This study focuses on assessing how the capital structure influences the financial performance of these medium-sized enterprises, based on an analysis of a sample of 30 agricultural SMEs over a period of 4 years from 2019 to 2022. This examination delves into the effects of debt, government subsidies, and their combined impact on the return on equity and assets of these SMEs. The findings reveal a significant negative correlation between capital structure and the financial performance of agricultural SMEs. This underscores the importance of advocating for self-financing in line with the pecking order theory, as debt appears to significantly diminish asset returns. Additionally, although government subsidies alone do not significantly influence enterprise profitability, their interplay with capital structure—especially long-term debt—exhibits a detrimental moderating effect on asset returns. This suggests that subsidies play a significant role in moderating the relationship between capital structure and SME financial performance, albeit with an adverse effect.
Assessing Industrial Past and Cultural Changes in Industrial Lands along the Hangzhou Section of the Grand Canal in China
Authors: Cao Furan , Zhu Bin , Huang Lingyan , Liu Chao
Published: June 2024

The Grand Canal has been fundamental in supporting Chinese industrialization, as evidenced in the great changes witnessed across industrial lands, but few studies have approached this issue from a cultural perspective. After an extensive industrial recession in the early 21st century, canal cities like Hangzhou have seen changes in the cultural functions of industrial lands, relocating, transforming, and demolishing factories and other constructions to develop new cultural spaces and products. A deep analysis of these cultural changes is, therefore, quite helpful to appreciate the features of and reasons for Chinese national policy setting in the cultural sections of the Grand Canal, such as the UNESCO World Heritage-recognized purpose of the Grand Canal, etc. Therefore, by focusing on the Hangzhou section of the Canal, and via the integration of high-resolution Google Earth images with a 1.5 spatial resolution, we dynamically monitored the land use of the 10 specifically selected industrial lands and interpretated the various uses of the areas from 2000 to 2020. Then, with archival data from 1950 to 2024 and fieldwork conducted over 1 year, and in consultation with major experts, we designed a mark sheet with factors and scores to comprehensively assess cultural changes in those lands. Consequently, the history of industrialization along the Hangzhou section was thoroughly analyzed with these investigations and data, and the reasons for and influence of cultural changes were presented in detail; subsequently, the outstanding problems were addressed, and suggestions were offered. This study contributes to a better understanding of Chinese cultural policy regarding cities along the Canal after the industrial decline, especially the critical implication of cultural loss within these cities. In addition, it also provides novel perspectives for cultural research, heritage conservation, and urban planning of canals or waterfront spaces for world heritage.
Residential Satisfaction of Subsidized Housing Estates in Post-Reform China: Roles of the Built and Social Environments
Authors: Tang Qijing , Wei Zongcai , Huang Shaoqi
Published: June 2024

Residential satisfaction has been heavily discussed worldwide amid the increasing emphasis on the social dimension of sustainability. However, consensus has not been reached regarding its determinants, and little research has focused on the subsidized housing estates (SHEs) in post-reform China. Using data collected from field observations in Guangzhou, this study developed a conceptual framework on the basis of the ACSI and Campbell’s models and employed structural equation modeling to investigate what and how factors pertaining to both the built and social environments influenced residential satisfaction of SHEs. Generally, SHE residents were moderately satisfied with their housing estates, although challenges persisted in estate management and security, suggesting that the performance of China’s subsidized housing policies were acceptable. Echoing existing arguments, this empirical investigation revealed the substantial positive roles played by both the built and social environments in shaping residential satisfaction. Specifically, the livable built environment characterized by large housing size and well-equipped neighborhoods, coupled with the friendly social environment marked by intimate neighborly relationships and diverse community activities, correlated with an elevated level of residential satisfaction of SHEs. Importantly, residents’ subjective perceptions of the built environment emerged as the most influential factor, which acted a significant mediating role, linking both objective attributes and individual expectations to residential satisfaction. This underscored the necessity of integrating public opinions into the planning process to meet SHE residents’ actual desires. These findings not only extended the scholarly discourse on residential satisfaction, especially among disadvantaged groups in low-income housing estates, but also advanced urban sustainable development by providing references for enhancing SHE performance.
The Contribution of Saline-Alkali Land to the Terrestrial Carbon Stock Balance: The Case of an Important Agriculture and Ecological Region in Northeast China
Authors: Chang Lei , Ju Tianhang , Liu Huijia , Li Yuefen
Published: June 2024

Saline-alkali land is an important component of terrestrial ecosystems and may serve as a carbon sink but its net contribution to the overall terrestrial carbon sink is unknown. Using methods recommended by the IPCC, this study evaluates the impacts of interconverting saline-alkali and non-saline-alkali land on terrestrial carbon stocks by measuring two major carbon pools (soil organic carbon and vegetation carbon) in the saline-alkali land of China’s Songnen Plain. Distinct phases in the evolution of the region’s terrestrial carbon stock were delineated, factors contributing to transitions between phases were identified, and the effects of changes in the saline-alkali land carbon stock on the overall terrestrial carbon sink were estimated. Between 2005 and 2020, the region’s saline-alkali land carbon stock initially increased, then declined, and finally increased again. However, the overall terrestrial carbon stock decreased by 0.5 Tg (1 Tg = 1012 g), indicating that the increase in the saline-alkali land carbon stock was due primarily to expansion of the saline-alkali land area. The conversion of non-saline-alkali land to saline-alkali land was a carbon-emitting process; consequently, in areas undergoing saline-alkali land change, the lower carbon density bound was equal to the carbon density of unconverted saline-alkali land and the upper bound was equal to the carbon density of unconverted non-saline-alkali land. In general, changes in the carbon stock of saline-alkali land correlated negatively with changes in the overall terrestrial carbon stock. The conversion of saline-alkali land into grassland and cropland through biochar improvement and the planting of saline-tolerant crops (Leymus chinensis, salt-tolerant rice) has a positive effect on promoting the enhancement of terrestrial carbon stocks.
Butyrate- and Beta-Hydroxybutyrate-Mediated Effects of Interventions with Pro- and Prebiotics, Fasting, and Caloric Restrictions on Depression: A Systematic Review and Meta-Analysis
Authors: Breuling Marian , Tomeva Elena , Ivanovic Nevena , Haslberger Alexander
Published: June 2024

To examine the butyrate- and beta-hydroxybutyrate (BHB)-modulated effects of pre- and probiotic interventions, fasting, and caloric restriction interventions, a systematic literature review was carried out with a subsequent meta-analysis. Three pre-and probiotic intervention randomized control trials (RCTs) were included in the meta-analysis. A significant increase in butyrate (standardized mean difference (SMD) [confidence interval (CI)] 0.34; [0.02–0.67]) and an improvement in depression scores (SMD [CI] 0.15, [−0.35–0.70]) through pre- and probiotic interventions were shown in the meta-analysis. The intervention duration of the included studies ranged from three days to four weeks, with the examined population being healthy adults. Butyrate was measured in either plasma or feces, and the depression score was obtained under the Swedish core affect scale, the hospital anxiety and depression scale (HADS), or the depression, anxiety, and stress scale—21 items (DASS-21). In addition to butyrate, the total SCFA concentration also seems to be positively associated with pre- and probiotic administration (SMD [CI] 0.55 [0.15–0.95]). Despite the significant short-chain fatty acid (SCFA) and butyrate concentration changes, no significant correlation between butyrate and depression or between SCFAs and depression could be shown through linear regression models. Nevertheless, the regression coefficient b1 = 1.57 (p = 0.17) for butyrate suggests a strong, positive connection between butyrate and depression. Additionally, three studies were qualitatively analyzed, examining fasting as an intervention and revealing a connection between fasting, BHB, and depression. The association between fasting, BHB, and depression or mood elevation appeared to be related to BHB concentrations, which may be due to the similar biochemical properties of BHB and butyrate. Furthermore, caloric restrictions as alternatives to fasting were proposed as potential long-term interventions.
Effect of Harmful Bearing Currents on the Service Life of Rolling Bearings: From Experimental Investigations to a Predictive Model
Authors: Schneider Volker , Krewer Marius , Poll Gerhard , Marian Max
Published: June 2024

This study investigates the effects of harmful bearing currents on the service life of rolling bearings and introduces a model to predict service life as a function of surface roughness. Harmful bearing currents, resulting from electrical discharges, can cause significant surface damage, reducing the operational lifespan of bearings. This study involves comprehensive experiments to quantify the extent of electrical stress caused by these currents. For this purpose, four series of tests with different electrical stress levels were carried out and the results of their service lives were compared with each other. Additionally, a novel model to correlate the service life of rolling bearings with varying degrees of surface roughness caused by electrical discharges was developed. The basis is the internationally recognized method of DIN ISO 281, which was extended in the context of this study. The findings show that the surface roughness continues to increase as the electrical load increases. In theory, this in turn leads to a deterioration in lubrication conditions and a reduction in service life.
Extracting Interpretable Knowledge from the Remote Monitoring of COVID-19 Patients
Authors: Tziomaka Melina , Kallipolitis Athanasios , Menychtas Andreas , Gallos Parisis , Panagopoulos Christos , Vassiliou Alice Georgia , Jahaj Edison , Dimopoulou Ioanna , Kotanidou Anastasia , Maglogiannis Ilias
Published: June 2024

Apart from providing user-friendly applications that support digitized healthcare routines, the use of wearable devices has proven to increase the independence of patients in a healthcare setting. By applying machine learning techniques to real health-related data, important conclusions can be drawn for unsolved issues related to disease prognosis. In this paper, various machine learning techniques are examined and analyzed for the provision of personalized care to COVID-19 patients with mild symptoms based on individual characteristics and the comorbidities they have, while the connection between the stimuli and predictive results are utilized for the evaluation of the system’s transparency. The results, jointly analyzing wearable and electronic health record data for the prediction of a daily dyspnea grade and the duration of fever, are promising in terms of evaluation metrics even in a specified stratum of patients. The interpretability scheme provides useful insight concerning factors that greatly influenced the results. Moreover, it is demonstrated that the use of wearable devices for remote monitoring through cloud platforms is feasible while providing awareness of a patient’s condition, leading to the early detection of undesired changes and reduced visits for patient screening.
A Fuzzy Entropy Approach for Portfolio Selection
Authors: Bonacic Milena , López-Ospina Héctor , Bravo Cristián , Pérez Juan
Published: June 2024

Portfolio management typically aims to achieve better returns per unit of risk by building efficient portfolios. The Markowitz framework is the classic approach used when decision-makers know the expected returns and covariance matrix of assets. However, the theory does not always apply when the time horizon of investments is short; the realized return and covariance of different assets are usually far from the expected values, and considering additional factors, such as diversification and information ambiguity, can lead to better portfolios. This study proposes models for constructing efficient portfolios using fuzzy parameters like entropy, return, variance, and entropy membership functions in multi-criteria optimization models. Our approach leverages aspects related to multi-criteria optimization and Shannon entropy to deal with diversification, and fuzzy and fuzzy entropy variants provide a better representation of the ambiguity of the information according to the investors’ deadline. We compare 418 optimal portfolios for different objectives (return, variance, and entropy), using data from 2003 to 2023 of indexes from the USA, EU, China, and Japan. We use the Sharpe index as a decision variable, in addition to the multi-criteria decision analysis method TOPSIS. Our models provided high-efficiency portfolios, particularly those considering fuzzy entropy membership functions for return and variance.
Dynamic Credible Spectrum Sharing Based on Smart Contract in Vehicular Networks
Authors: Li Qinchi , Wang Qin , Zhao Haitao , Chang Tianshui , Yang Yuting , Xia Sisi
Published: June 2024

With the rapid development of the Internet of Vehicles (IoV), the demand for wireless spectrum resources has significantly increased. Dynamic spectrum sharing technology is regarded as a key solution to alleviate the shortage of spectrum resources. However, during the spectrum sharing process, security issues and a low utilization of the shared spectrum may arise. This study designs a consortium blockchain for trustworthy dynamic spectrum sharing in IoV environments. An improved asynchronous byzantine fault-tolerant algorithm is also designed to address the instability of signals in this scenario, and the allocation and management of spectrum resources between vehicles and base stations are further optimized using the Stackelberg game, ultimately deployed automatically through smart contracts. Simulation results show that our method not only significantly improves the system’s response time but also ensures communication quality and can maintain efficient operation under high network delay and complex scenarios.
Comparison of the Effects of Multiple Frailty and Nutritional Indexes on Postoperative Outcomes in Critically Ill Patients Undergoing Lung Transplantation
Authors: Lee Sang-Wook , Lee Donghee , Choi Dae-Kee
Published: June 2024

Background and Objective: Lung transplantation is the only life-extending therapy for end-stage pulmonary disease patients, but its risks necessitate an understanding of outcome predictors, with the frailty index and nutritional status being key assessment tools. This study aims to evaluate the relationship between preoperative frailty and nutritional indexes and the postoperative mortality rate in patients receiving lung transplants, and to determine which measure is a more potent predictor of outcomes. Materials and Methods: This study reviewed 185 adults who received lung transplants at a single medical center between January 2013 and May 2023. We primarily focused on postoperative 7-year overall survival. Other outcomes measured were short-term mortalities, acute rejection, kidney complications, infections, and re-transplantation. We compared the predictive abilities of preoperative nutritional and frailty indicators for survival using receiver operating characteristic curve analysis and identified factors affecting survival through regression analyses. Results: There were no significant differences in preoperative nutritional indicators between survivors and non-survivors. However, preoperative frailty indicators did differ significantly between these groups. Multivariate analysis revealed that the American Society of Anesthesiologists Class V, clinical frailty scale, and Charlson Comorbidity Index (CCI) were key predictors of 7-year overall survival. Of these, the CCI had the strongest predictive ability with an area under the curve of 0.755, followed by the modified frailty index at 0.731. Conclusions: Our study indicates that for critically ill patients undergoing lung transplantation, frailty indexes derived from preoperative patient history and functional autonomy are more effective in forecasting postoperative outcomes, including survival, than indexes related to preoperative nutritional status.
Impact of Modified Diet, Swallowing Exercises, and Electrostimulation on Quality of Life of Older Patients Suffering from Oropharyngeal Dysphagia
Authors: Rugaitienė Margarita , Lesauskaitė Vita , Ulozienė Ingrida , Smičius Lukas , Damulevičienė Gytė
Published: June 2024

Background and Objectives: Oropharyngeal dysphagia is defined as a swallowing disorder in which it becomes difficult to form a bolus and move food from the mouth to the proximal part of the esophagus. Several factors can cause this disorder in geriatric patients. With oropharyngeal dysphagia, the patient’s social isolation and the risk of depression increase, while the quality of life deteriorates. Materials and Methods: In this study, oropharyngeal dysphagia was suspected based on the EAT-10 questionnaire and diagnosed with the water drink test and endoscopic swallowing evaluation, which assesses the aspiration risk by using an eight-point Penetration–Aspiration scale. Patients with oropharyngeal dysphagia received complex treatment: exercises to strengthen the swallowing muscles, electrostimulation of the swallowing muscles, and a modified diet. The quality of life of 64 patients was assessed by using the DHI, SWAL-QoL, and EAT-10 questionnaires before complex treatment and after treatment. The results show that the quality of life improved after the complex treatment of oropharyngeal dysphagia. Results: The mean age of patients was 77.8 (9.1) years, and 56.3% of patients were women. At baseline, mild oropharyngeal dysphagia was found in 18.8% of patients; moderate—in 51.6%; and severe—in 29.7%. Aspiration risk was low in 28.1% of patients; medium—in 39.1%; and high—in 32.8%. The severity of oropharyngeal dysphagia and aspiration risk significantly decreased after treatment (p = 0.002). The EAT-10 score mean was 15.23 (8.92) points before treatment and decreased to 11.50 (6.12) points after treatment (p < 0.001). Before treatment, the DHI physical score was 15.75 (6.813), the DHI functional score was 14.56 (8.659), and the DHI emotional score was 11.06 (7.848) (p < 0.001), and after complex treatment, the DHI physical score was 14.56 (8.659), the DHI functional score was 9.74 (7.165), and the DHI emotional score was 7.94 (6.588) (p < 0.001). The total SWAL-QoL score mean was 132.71 (34.392) points before treatment and increased to 152.42 (30.547) points after treatment (p < 0.001). Conclusions: Complex treatment of oropharyngeal dysphagia plays an important role in improving the quality of life and reducing aspiration risk in older people affected by this condition.
Factors Associated with False Positive Breast Cancer Results in the Real-Time Sonoelastography Evaluation of Solid Breast Lesions
Authors: Eremici Ivana , Borlea Andreea , Dumitru Catalin , Stoian Dana
Published: June 2024

Background and Objectives: Breast cancer is one of the most widespread cancers among the female population around the world and is curable if diagnosed in an early stage. Consequently, breast cancer screening imaging techniques have greatly evolved and adjusted over the last decades. Alongside mammography, sonoelastography became an important tool for breast cancer detection. However, sonoelastography still has its limitations, namely, there is still a high occurrence of false positive results in the BIRADS 4 category. The aim of our study is to identify potential false positive predictors and to ascertain the factors influencing the quality of strain ultrasound elastography for the evaluation of suspicious solid breast lesions categorized as BIRADS 4B, 4C, and 5. Materials and Methods: We conducted a retrospective study in a single private medical center in Timisoara between January 2017 and January 2022 analyzing 1625 solid breast lesions by the sonoelastography strain using a standardized BIRADS-US lexicon. Results: Our study showed that most sonoelastography factors linked to incorrect and overdiagnosis were due to a nodule dimension (OR = 1.02 per unit increase), posterior acoustic shadowing (OR = 12.26), reactive adenopathy (OR = 6.35), and an increased TES score (TES3 OR = 6.60; TES4 OR = 23.02; TES5 OR = 108.24). Regarding patient characteristics, age (OR = 1.09 per unit increase), BMI, (OR = 1.09 per unit increase), and breastfeeding history (OR = 3.00) were observed to increase the likelihood of false positive results. On the other hand, the nodules less likely to be part of the false positive group exhibited the following characteristics: a regular shape (OR = 0.27), homogenous consistency (OR = 0.42), and avascularity (OR = 0.22). Conclusions: Older age, high BMI, patients with a breastfeeding history, and those who exhibit the following specific nodule characteristics were most often linked to false positive results: large tumors with posterior acoustic shadowing and high elasticity scores, accompanied by reactive adenopathy. On the other hand, homogenous, avascular nodules with regular shapes were less likely to be misdiagnosed.
Preparation and Characterization of Duplex PEO/UV-Curable Powder Coating on AZ91 Magnesium Alloys
Authors: Florczak Łukasz , Pojnar Katarzyna , Kościelniak Barbara , Pilch-Pitera Barbara
Published: June 2024

Magnesium alloys, because of their excellent strength-to-weight ratio, are increasingly used in many industries. When used in external elements, the key factor is to provide adequate anticorrosion protection. High-temperature, cured-powder coatings are widely used to protect most metals, but their use on magnesium alloys is difficult as a result of the instability of the magnesium substrate at elevated temperatures. Another problem is ensuring the proper adhesion of the organic coating to the magnesium substrate. This paper presents the procedure for the synthesis of a duplex coating on AZ91 magnesium alloy. The topcoat was a powder coating based on acrylic resin, the main ingredient of which was glycidyl methacrylate. Because of the presence of epoxy groups, the coating was cured using ultraviolet (UV) radiation (low-temperature technology). The conversion subcoating was produced by plasma electrolytic oxidation (PEO) in an alkaline silicate electrolyte. The synthesized coating system was tested, among others, for microscopic (SEM), adhesive (mesh of cuts), and anticorrosion (EIS). The duplex PEO/UV-curable powder coating showed very good adhesion to the metal and increased the anticorrosion properties of the magnesium substrate, compared to the powder coating produced directly on the magnesium alloy and on an alternative conversion coating (synthesized in the process of chemical zircon phosphating).
Thermomechanical Behavior of CuAlMn SMA Cellular Structures Obtained by Rapid Investment Casting
Authors: Alves Railson M. N. , Silva Paulo C. S. , Cavalcante Danielle G. L. , Oliveira Danniel F. , De Araújo Carlos J. , Delgado João M. P. Q. , Lima Antonio G. B.
Published: June 2024

Shape memory alloy (SMA) bidimensional cellular structures (CSs) have a great potential application in attenuation of vibrations due to reversible martensitic phase transformations induced by thermal or mechanical loading. This work aims to produce a thermal and mechanical characterization of CuAlMn SMA CSs produced by rapid investment casting (RIC). Structures with different unit cell geometries and thicknesses of 0.5 mm and 1 mm were manufactured by centrifugal RIC. Compression tests at different temperatures were performed on the CS to verify its thermomechanical behavior. We observed that a CS with a thickness of 0.5 mm presents greater mechanical strength and lower levels of maximum force at the end of each 5% compression cycle, ranging from approximately 1/10 to 1/3, compared to structures with a thickness of 1 mm. Among all the CS configurations, the re-entrant structure exhibited higher levels of force, with higher secant stiffness and dissipated energy. The structures resisted the application of compressive forces that varied between 125 N and 500 N for the 0.5 mm CS and between 500 N and 5500 N for the 1 mm CS. Therefore, the results showed that all CuAlMn SMA CSs produced by RIC exhibited sufficient strength to attain strain levels of up to 5% at different temperatures, and that the unit cell geometry can be used to tune the mechanical properties.
Effect of Ag and Cu Content on the Properties of Zn-Ag-Cu-0.05Mg Alloys
Authors: Jara-Chávez Gloria , Amaro-Villeda Adrián , Campillo-Illanes Bernardo , Ramírez-Argáez Marco , González-Rivera Carlos
Published: June 2024

Zn-Ag-Cu alloys have recently attracted attention as alloy candidates for biomedical applications, but, to date, they have not achieved the required mechanical properties. To improve the mechanical properties of Zn-Ag-Cu-base alloys, in this work, the effects of the presence of increasing amounts of Ag and Cu as alloying elements on the properties of four 0.05% Mg-micro-alloyed Zn-Ag-Cu base alloys are explored. The alloys were manufactured in an electric furnace with a protective atmosphere using increasing amounts of Ag and Cu as alloying agents, and were cast in a metallic mold. The samples obtained were thermomechanically processed by hot extrusion. Three of the four alloys under study presented increasing amounts of the second phase (Ag, Cu)Zn4, high mechanical properties, a microstructure and mechanical behavior characteristic of heteromaterials with a heterogeneous lamella-structure, and met the requirements of the mechanical properties, corrosion rate, antibacterial properties against S. aureus, and the cytotoxicity required for biomedical applications. It seems possible to tune the properties of the ZnAgCu-0.05% Mg alloys by changing the Ag and Cu contents.
Effects of the Menstrual Cycle and Hormonal Contraceptive Use on Metabolic Outcomes, Strength Performance, and Recovery: A Narrative Review
Authors: Cabre Hannah E. , Gould Lacey M. , Redman Leanne M. , Smith-Ryan Abbie E.
Published: June 2024

The effects of female sex hormones on optimal performance have been increasingly recognized as an important consideration in exercise and sport science research. This narrative review explores the findings of studies evaluating the effects of menstrual cycle phase in eumenorrheic women and the use of hormonal contraception (oral contraceptives and hormonal intrauterine devices) on metabolism, muscular strength, and recovery in active females. Ovarian hormones are known to influence metabolism because estrogen is a master regulator of bioenergetics. Importantly, the menstrual cycle may impact protein synthesis, impacting skeletal muscle quality and strength. Studies investigating muscular strength in eumenorrheic women report equivocal findings between the follicular phase and luteal phase with no differences compared to oral contraceptive users. Studies examining recovery measures (using biomarkers, blood lactate, and blood flow) do not report clear or consistent effects of the impact of the menstrual cycle or hormonal contraception use on recovery. Overall, the current literature may be limited by the evaluation of only one menstrual cycle and the use of group means for statistical significance. Hence, to optimize training and performance in females, regardless of hormonal contraception use, there is a need for future research to quantify the intra-individual impact of the menstrual cycle phases and hormonal contraceptive use in active females.