bluuebunny/crossref_metadata_2025 huggingface dataset:
Appraisal for multiple disease resistance in advanced breeding lines of tomato (Solanum lycopersicum L.)
Authors: Rane Omkar , Jindal S K , Dhaliwal M S , Sharma Abhishek , Kaur Sukhjeet , Gill Rupeet
Published: March 2023

The leaf curl disease (ToLCD), late blight (LB) and root knot nematode (RKN) are the major obstacles for rainy season tomato production all over the world. Several tactics are being considered for the management of these diseases. Reportedly, the most efficient ease of manage these multiple diseases is to adopt resistant cultivars. Though, work on development of resistant cultivars against multiple diseases are very confined due to non-availability of the resistant sources. In the present study, BC2F6population comprising 132 elite tomato lines were evaluated using different screening techniques including marker assisted selection (MAS) during 2019-2020 and 2020-2021. Punjab Chuhhara (check) was employed susceptible for all three diseases while PVB-4, LBR-10 and NR-14 were the resistant checks for ToLCD, LB and RKN, respectively. The lines which showed resistance and moderately resistance responses under field and artificial conditions were exposed for MAS of major resistant genes (Ty-1, Ty-2, Ty-3, Ph-2,Ph-3andMi-1.2). PDRT-104, PDRT-118, PDRT-122, PDRT-124 and PDRT-125 were found to be multiple disease resistant. There was significant correlation between the phenotypic and genotypic based screening. The resistant lines identified in the present evaluation can be utilized in commercial varieties for durable resistance to multiple diseases.
Immunophysiology of tambaqui fed with different levels of dietary protein in a biofloc system and a clear water system
Authors: FUGIMURA³ Michelle Midori Sena , de FREITAS¹ Thiago Mendes , GALLANI¹ Sílvia Umeda , Claudiano Gustavo da Silva , ONO Eduardo Akifumi , AFFONSO Elizabeth Gusmão , IZEL-SILVA Judá , de MEDEIROS Paulo Adelino , Santos Raphael Brito Dos
Published: March 2023

The present study evaluated the immunophysiological response in Colossoma macropomum fed with different levels of dietary protein in a biofloc system (BFS) and in clear water (CW) and under infection with Aeromonas jandaei. Juvenile tambaqui (9.20 ± 0.23 g) were fed isolipid feed with three levels of crude protein (CP) in the two production systems: BFS24, BFS28 and BFS32 and CW24, CW28 and CW32 with 24, 28 and 32% CP respectively, for 60 days. At the end of the experimental period, the physiological conditions (hematology, biochemistry, hormonal and oxidative stress) of the fish were analyzed. The results of erythrogram, cortisol, glycemia and serum biochemistry (p > 0.05) of the fish did not show significant differences between the breeding systems (BFS and CW) and the different protein levels. Tambaqui raised in the BFS showed monocytosis, thrombocytosis and higher respiratory activity of leukocytes, as well as higher glutathione (GSH) and lower malondialdehyde (MDA) values (p < 0.05). In the bacterial challenge, after induction of aeromonosis, caused by Aeromonas jandaei, greater survival of fish raised in the BFS was observed. The results suggest that, even at lower protein levels, tambaqui maintain physiological homeostasis and, therefore, it may be possible to use up to 24% CP in the diet in the biofloc system. In addition, after the bacterial infection, this system promoted greater immunological resistance in the fish.
On the effect of the variation of velocity fields in
pulsars
Authors: Du Shuang
Published: March 2023

Glitches are sudden spin-up events in pulsars and are usually thought to be induced by unpinning of neutron superfluid vortices in their crusts. Unpinning and repinning of superfluid vortices, and even thermoelectric effects induced by the deposited heat released during glitches, may vary the velocity fields in pulsars. We demonstrate that the generally invoked magnetic dipole fields of pulsars cannot remain stationary during the variation of the velocity fields and that multipole components must be generated. We argue that comparing the fine structures (i.e., spark frequencies) of periodic radio pulses before and after glitches can physically test the mathematical justification. Based on the effect of the variation of the velocity field on the magnetic field, the interpretations of pulse nulling, rebrightning of radio-quiet magnetars in the radio band, differences between Crab pulsar and Vela pulsar after glitches, and extra-galactic fast radio burst-like events from SGR 1935+2154 are presented.
Piaractus mesopotamicus is hypoxia tolerant and performs antioxidant adjustments after rapid reoxygenation at low temperature
Authors: Nitz Lilian Fiori , Pellegrin Lucas , Pinto Daniel , Monserrat José María , Copatti Carlos Eduardo , Garcia Luciano
Published: March 2023

This study aimed to evaluate the effects of the different temperature interactions and reoxygenation rates on parameters of antioxidant defense and oxidative stress in pacu (Piaractus mesopotamicus) juveniles. The fish were exposed to 12 h of hypoxia (~2 mg O2 L−1) with subsequent rapid or gradual reoxygenation (with a return to normoxic levels in 0.5 or 5 h, respectively) in interaction with three different temperatures (~18, ~23, and ~28ºC). A control group in normoxia (~7 mg O2 L−1) was also evaluated for each temperature, which was neither submitted to hypoxia nor reoxygenation, totaling nine treatments in triplicate. After 1 and 12 h of the end of the reoxygenation period, samples of gills and liver were collected to determine the total antioxidant capacity against peroxyl radicals (ACAP), lipid peroxidation (LPO), and protein thiol content (PSH). Results showed temporary changes in ACAP in both organs, where, in general, the lowest levels were found at 18 and 28oC at 1 and 12 h after recovery, respectively. A reduction of LPO levels in gills occurred in interactions between 18°C and rapid reoxygenation and 23oC and gradual reoxygenation after recovery (1 and 12 h). Liver LPO levels were higher at 23oC at 1 and 12 h after recovery. In general, gills PSH content was lower at 18 than at 23oC at 1 h after recovery. Liver PSH content was higher at 23°C after recovery (1 and 12 h). In conclusion, pacu juveniles are hypoxia tolerant and cope better with rapid reoxygenation at 18oC. Furthermore, the adjustments of the antioxidant system performed by the fish were sufficient for the partial resumption of homeostasis 12 h after recovery.
Complex topology of ubiquitin chains mediates lysosomal degradation of MrgC proteins
Authors: Yu Jiacheng , Li Dan , Liang Ying , Xie Mingming , Xie Jun , Wang Zhen , Gu Xiaoping , Ma Zhengliang , Sun Yu’e
Published: March 2023

BACKGROUND
Ubiquitin-mediated Mas-related G protein-coupled receptor C (MrgC) degradation contributes to development of agonist resistance. It has been shown that inhibition of ubiquitin-activating enzymes reduces the ubiquitination of MrgC. In this study we investigated the ubiquitin degradation pathway and ubiquitin chain type of MrgC.
METHODS
The degradation pathway of MrgC was studied by treating N2a cells with autophagy lysosome inhibitor and proteasome inhibitor. N2a cells were transfected with mutant ubiquitin plasmids to study the ubiquitin chain type of MrgC.
RESULTS
Autophagy lysosome inhibitors can inhibit the degradation of MrgC. Intracellular MrgC co-localized with lysosomes. MrgC proteins can link multiple types of ubiquitin chains.
CONCLUSION
Complex topology of ubiquitin chains mediates lysosomal degradation of MrgC proteins. Inhibition of ubiquitination degradation of MrgC may avoid agonist resistance of MrgC, maintaining its biological activity.
Human capital structure and export quality. The mediation of innovation capacity.
Authors: ChenyuWang  , XiaoweiZhou
Published: March 2023

This paper aims to research the direct and indirect effects of human capital structure on export quality at the firm level. The empirical analysis is carried out using firm-year data by matching three Databases based on specific rules. The Benchmark regression directly verifies the positive effect of human capital structure on export quality. Moreover, the intermediary effect test suggests that innovation capacity is a channel for the human capital structure to improve export quality. However, the mediating effect only accounts for 17% of the total effect that human capital structure plays on export quality. Additionally, this paper finds that the influence of local human resources on a firm's human capital structure varies by region, with firms in the eastern region having a significant impact on intermediation effects compared to those in the central and western regions.
Experimental study on microstructure and strength behaviors of cement and micro-silica-stabilized saline soil under freezing-thawing cycles
Authors: Li Shengang , Zhang Chaozhe , Zhang Tianbiao , Li Wentao , Jia Pengjiao
Published: March 2023

The authors have requested that this preprint be removed from Research Square.
The sine and cosine diffusive representations for Caputo fractional derivative: A matrix approach to multi-term fractional differential equations
Authors: Khosravian-Arab Hassan , Dehghan Mehdi
Published: March 2023

In the last decade, there has been a surge of interest in application of fractional calculus in various areas such as, mathematics, physics, engineering, mechanics and etc. So, numerical methods have rapidly been developed to handle problems containing fractional derivatives (or integrals). Due to the fact that all the operators which appear in fractional calculus are non-local, so, the classical linear multi-step methods have some diffculties from the point of view of (time/space) computational complexity. Recently, two newnon-classical methods or diffusive based methods have been proposed by the authors to approximate the Caputo fractional derivatives. Here, the main aim of this paper is to use these methods to solve linear multi-term fractional differential equations numerically. To reach our aim, an effcient matrix approach hasbeen provided to solve some well-known multi-term fractional differential equations.
Mathematics Subject Classifications (2000): 26A33; 65D30; 65D25; 65D32.
The positive impact of cancer genetic counseling on patients from an underserved region in Brazil
Authors: Coutinho Jessica Dayanna Landivar , Sales Lucas Amadeus Porpino , Timóteo Ana Rafaela Souza , Salha Daniella Regina Arantes Martins , Sales Sílvio Correia , Gonçalves Ana Elida Menezes Magalhães , Santos Ythalo Hugo Silva , Petta Tirzah Braz
Published: March 2023

Introduction: Genetic counseling (GC) has become a pivotal health service to manage high-risk patients with hereditary cancer. Brazil is a continental country with an admixture population that is suggested to have a high internal genetic variation. Here we describe the impact of GC in an underdeveloped area of Brazil which offered GC for hereditary cancer for the past 10 years.
Methods: Retrospective cohort study with patients seen at the CG service from 2009 to 2019. All patients have undergone genetic testing and Hospital Anxiety and Depression Scale (HADS) was applied to assess psychological symptoms after genetic testing. Associations between variables were verified using Fisher's Exact Test, and survival analysis was estimated by Kaplan–Meier.
Results: The GC service has included 139 patients, where 89.3% of patients had less than 60y, 63.3% had high-school graduate only, 91% had breast cancer as a primary diagnosis and 23.7% carries a germline pathogenic variant (PV) in high-risk genes. The 5 years overall survival was 88.6%, with no significant difference between patients with germline mutation (95% CI, p= 0.138). After GC, 68.7% and 55.6% of the patients had a normal score for depression and anxiety, respectively, regardless of age at diagnosis. Moreover, the decision of undergoing risk-reducing mastectomy (RRM) was not influenced by depressive or anxious symptoms, but by age, where 44% of women aged more than 60y did not present a willingness to undergo RRM. Among patients with PV, 91.7% could understand the meaning of germline mutation and the implications to health and 58% stated that the diagnosis of PV stimulated to modification of unhealthy habits. Low education level was significantly related to a limited understanding of the impact of carrying a PV.
Conclusion: These results reflect the positive impact of GC in an underserved region of Brazil and highlight the importance of communicating with patients with low education levels.
Risk Factors for Malignant Transformation of Oral Lichen Planus
Authors: Gómez-Armayones Sara , Tous Sara , Chimenos-Küstner Eduardo , Arranz Carlos , Marquez Sandra , Penín Rosa-Maria , Quirós Beatriz , Taberna Miren , Alemany Laia , Servitje Octavio , Mena Marisa
Published: March 2023

We aimed to identify factors for malignant transformation of oral lichen planus to oral cancer in order to inform the different specialists undertaking their clinical management. A retrospective cohort of biopsy-confirmed oral lichen planus consecutively diagnosed in 1995–2014 and followed-up until 2017 was selected. Demographic, clinical and follow-up information was collected. Multivariate Cox proportional-hazards models were performed to evaluate clinical and pathological factors associated with progression to oral cancer. The study included 257 oral lichen planus of which 5.4% progressed to oral cancer. Men and women differed in tobacco and alcohol consumption, and patients with and without described clinical aspect differed in diagnostic period, alcohol consumption and treatment. Alcohol consumption, tongue site, oldest diagnostic period and surgery as a type of treatment were independent prognostic factors for progression. This large non-selected retrospective cohort of oral lichen planus underscores the existing limitations of the current standard-of-care of such lesions. Well-designed, robust prospective studies and multidisciplinary treatment guidelines are warranted.
Exploring the Dilemmas of Leadership: Voices from the Field
Authors: Wesson Linda Hampton
Published: March 2023

Although women comprise a majority of the nation's public school teaching force, most school administrators are white males, and at the highest level in public school administration, the superintendency, there seems to be a great deal of resistance to gender and minority integration.
An Analyses of Federal Initiatives to Support Women's Upward Mobility in Educational Administration
Authors: Gupton Sandra Lee , Del Rosario Rose Marie
Published: March 2023

No person in the United States shall, on the basis of sex, be excluded from participation in, be denied the benefits of, or be subject to discrimination under any educational programs or activity receiving federal financial assistance. --From the preamble to Title IX of the Education Amendments of 1972
Education and Women's Resiliency: Exploring the Experiences of Successful Women from Disadvantaged Backgrounds
Authors: Lepage-Lees Pamela
Published: March 2023

While some research has explored the needs of minority women, very little research has focused on women who have faced other disadvantages beyond those associated with minority status.
Paradigm Shift: A Perspective on OmaniWomen in Management in the Sultanate of Oman
Authors: Al-Lamki Salma
Published: March 2023

Organizations need talented women in their core jobs, therefore, not only for reasons of social fairness, important though that is, but because many of those women will have the kinds of attitudes and attributes that the new flat flexible organizations need. If they screen out the women they will handicap their future. Charles Handy
Reflections of a Female School Executive
Authors: Gipson Willa
Published: March 2023

Women rising in school leadership positions is becoming more of a reality than in years past. I believe this accomplishment is attributed to women taking more control of their careers instead of acting in a passive role waiting to be selected or appointed.
Befriending (White) Women Faculty in Higher Education?
Authors: Thayer-Bacon Barbara J.
Published: March 2023

In this essay Thayer-Bacon explores the issue of a chilly climate in higher education that is generated by some women, in particular White women, and the destructive behavior they bring to higher education that damages their programs, as well as their working relationships with colleagues and students. The author seeks to find ways to befriend women in higher education, her sisters of color as well as her White sisters. Thayer-Bacon's focus here is on White women. Her approach is to use stories from the field to illustrate problems that are analyzed, using a narrative style of philosophical argument
Short Course Handouts Bundle for the Training of Trainers Course: Introductory course to facilitating social learning and stakeholder engagement in natural resource management contexts
Authors: Weaver Martin , Rosenberg Eureta , Cockburn J , Thifhulufhelwi R , Chetty P , Mponwana M , Mvulane P
Published: March 2023

This document is a compilation of the course handouts (materials) developed and produced for the “Training of Trainers” Short Course – the full title of which is the: “Introductory course to facilitating social learning and stakeholder engagement in natural resource management contexts”
Emotional branding e engajamento do consumidor em tempos de pandemia em redes sociais
Authors: Barreto Lucas Silva , Freitas Vérica , Paula Verônica Angelica Freitas de
Published: March 2023

É em momentos de adversidade, como a pandemia de Covid-19, em que alguns sentimentos, tais como o medo e a solidão, são comuns, as redes sociais se tornaram canais para a busca de afeto, aceitação e informações sociais. O apelo emocional surge como uma estratégia que busca estabelecer uma conexão profunda com os consumidores nessas redes. Nesse contexto, o presente artigo investiga as práticas de emotional branding e a sua relação com o engajamento dos usuários nas redes sociais, no contexto da pandemia de Covid-19. Por meio de mineração de textos, foi analisada a presença de sentimentos positivos e negativos em publicações de 2019 e 2020 no Facebook®, considerando-se três marcas de moda no Brasil. Foi constatada a adoção mais frequente dessas estratégias a partir da pandemia, destacando-se a utilização de textos relacionados aos sentimentos de “força”, “carinho”, “segurança” e “vivacidade” e a menor utilização de textos relacionados a “diversão” e “animação”. Foi identificada uma correlação positiva entre a presença de conteúdo relacionado a “solidariedade”, “força” e “tolerância” e o engajamento dos usuários a partir de 2020. Os resultados do estudo reforçam a importância da congruência entre as ações das marcas nas redes sociais e as necessidades emocionais dos usuários em períodos de crise.
CHARACTERISTICS OF ACUTE ISCHEMIC STROKE PATIENTS DUE TO SMALL VESSEL OCCLUSION
Authors: Suherlim Richard , Angga Krishna Pramana Nyoman , Tini Kumara , Bagus Kusuma Putra Ida , Ayu Sri Indrayani Ida
Published: March 2023

Background: Ischemic stroke account for about 87% of all stroke cases. This study will focus on ischemic stroke due to small vessel occlusion as one of the subtypes based on TOAST (trial of ORG 10172 in acute stroke treatment).
Objective: To determine the characteristics of ischemic stroke patients caused by small vessel occlusion and are expected to be used as a basis for further research.
Methods: A descriptive observational retrospective study regarding the characteristics of acute ischemic stroke patients due to small vessel occlusion at Sanglah Hospital. Secondary data were obtained from patient medical records.
Results: The total number of cases of small vessel occlusion was 338. The majority of the sample were men (64.5%) between 40-60 years old (53.6%). Most of the samples were patients who had experienced an ischemic stroke for the first time (75.1%) with NIHSS (National Institute of Health Stroke Scale) scores showing mild (48.2%) and moderate (51.5%) symptoms. Around half of them had a history of hypertension (60.1%), dyslipidemia (59.5%), and diabetes mellitus (44.1%). The most common location of infarction was in the anterior circulation (77.5%) with almost the same ratio of right and left hemisphere locations.
Conclusion: Ischemic stroke due to occlusion of small vessels at Sanglah Hospital Denpasar for 3 years was 35.2% of the total ischemic stroke cases. Half of the total sample had classic vascular risk factors. Further research is needed to determine another effective treatment strategy other than just secondary prevention such as life style moderation to prevent recurrency.
Introduction for factors of success and failure by using IoT in project management
Authors:   Civil Engineering School, Universiti Sains Malaysia, George Town, Malaysia, Ishak Md Sayuti , AlSalem Yazan Zuhair ,   Civil Engineering School, Universiti Sains Malaysia, George Town, Malaysia
Published: March 2023

The Internet is a relatively recent endeavor that has continued without conclusion for a considerable length of time, growing in importance to individuals, organizations, and governments everywhere until we finally settled on the term Internet of Things (IoT) to describe its ubiquitous application of multiple technologies across all spheres of human endeavor. In addition, the variety of IoT applications and use cases expands annually. There will be a need for this trend to grow substantially in order to satisfy the enormous amount of demand. Whether or not an IoT application is successful, simple to deploy, and user-friendly depends on a number of things. Based on research on the causes of success and failure in the implementation of IoT, it has become clear that most studies focus on either success factors alone or failure factors alone; this paper aims to bridge that gap by discussing the factors that contribute to the Internet of Things' success and the factors that lead to its failure, both of which aid in the technology's growth and dissemination and provide guidance to experts in the field.
Política De Seguridad Hsts O Seguridad De Transporte Http Estricta Y Su Implementacion En Entornos Web.
Authors: Flórez Anderson S , Chacón José G , Chía Renzo A , Flórez Albenis E , Rodriguez Johel E
Published: March 2023

Este articulo consiste en determinar y mejorar la seguridad en aplicaciones web, utilizando la política de seguridad estricta HSTS en un servidor web Apache, la cual permitirá a los usuarios mediante un navegador web solo visualizar páginas web con https, bloqueando las páginas que no posean la capa de seguridad SSL/TLS. Secure Sockets Layer (SSL capa de puertos seguro) y Transport Layer Security (TLS seguridad de la capa de transporte) en su protocolo web y a su vez proteger la información que el usuario dispone, de tal forma que los atacantes no podrán convertir la página web con el protocolo de seguridad https en una página sin protocolo de seguridad http, manteniendo así este bien preciado protegido de manera segura, brindándole al usuario la confidencialidad, integridad y disponibilidad de la información.
Apoyando los Procesos de Aprendizaje del Lenguaje en Jóvenes en Situación de Discapacidad Cognitiva Mediante el Desarrollo de Aplicación Móvil Interactiva
Authors: Salas Álvarez Daniel , Barrera Víctor , Quiñonez Wiliam
Published: March 2023

The main purpose of this study is to support young people with cognitive disabilities in the process of learning the language and social skills of children, through the design and implementation of a mobile and interactive application, which had the participation active teachers and parents; This application includes a set of activities with a metacognitive approach associated with the identification of vowels, videos of facial praxis that serve as exercises for the development of speech, in addition, it includes a set of animal sounds so that the student can identify them. Likewise, it incorporates a set of images linked to fruits so that the student completes the information and this is registered in the application, in addition to all the previous modules, it has evaluation mechanisms to assess the learning of the students and thus be able to determine the contribution to the educational process.
The results obtained from the application in a test scenario in the Julio Cesar Miranda Educational Institution, headquarters, Corazón de Jesús in the Municipality of San Antero, show the potential of the tool as support to the training processes, due to the motivation of students and the facilities it offers when comparisons were made between the traditional way of teaching the language and the use of the application.
Using Plastic Wastes to Exemplify Justice Dimensions of Extended Producer Responsibility
Authors: Steenmans Katrien , Malcolm Rosalind
Published: March 2023

Extended Producer Responsibility (EPR) places liability, physical, financial, and/or informative responsibility for a product throughout its life cycle on its producer. Implementing such schemes is expected to result in many environmental and social benefits. Yet, academic and practitioner discussions on the mechanisms focus on environmental impacts, whereas social dimensions of EPR are often side-lined. This short communication contributes to addressing this gap by establishing a research agenda for the justice dimensions of EPR. For this purpose, initial links between EPR and justice – specifically waste colonialism, procedural justice, recognition justice, distributive justice, intra- and intergenerational equity, waste justice, and corrective justice – are set out, including where it affects products in their life cycles and examples of which stakeholders may be impacted, with plastic waste used to provide examples.
Conversational Agent Interventions for Mental Health Problems: Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors: He Yuhao , Yang Li , Qian Chunlian , Li Tong , Su Zhengyuan , Zhang Qiang , Hou Xiangqing
Published: March 2023

Background

Mental health problems are a crucial global public health concern. Owing to their cost-effectiveness and accessibility, conversational agent interventions (CAIs) are promising in the field of mental health care.

Objective

This study aims to present a thorough summary of the traits of CAIs available for a range of mental health problems, find evidence of efficacy, and analyze the statistically significant moderators of efficacy via a meta-analysis of randomized controlled trial.

Methods

Web-based databases (Embase, MEDLINE, PsycINFO, CINAHL, Web of Science, and Cochrane) were systematically searched dated from the establishment of the database to October 30, 2021, and updated to May 1, 2022. Randomized controlled trials comparing CAIs with any other type of control condition in improving depressive symptoms, generalized anxiety symptoms, specific anxiety symptoms, quality of life or well-being, general distress, stress, mental disorder symptoms, psychosomatic disease symptoms, and positive and negative affect were considered eligible. This study followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Data were extracted by 2 independent reviewers, checked by a third reviewer, and pooled using both random effect models and fixed effects models. Hedges g was chosen as the effect size.

Results

Of the 6900 identified records, a total of 32 studies were included, involving 6089 participants. CAIs showed statistically significant short-term effects compared with control conditions in improving depressive symptoms (g=0.29, 95% CI 0.20-0.38), generalized anxiety symptoms (g=0.29, 95% CI 0.21-0.36), specific anxiety symptoms (g=0.47, 95% CI 0.07-0.86), quality of life or well-being (g=0.27, 95% CI 0.16-0.39), general distress (g=0.33, 95% CI 0.20-0.45), stress (g=0.24, 95% CI 0.08-0.41), mental disorder symptoms (g=0.36, 95% CI 0.17-0.54), psychosomatic disease symptoms (g=0.62, 95% CI 0.14-1.11), and negative affect (g=0.28, 95% CI 0.05-0.51). However, the long-term effects of CAIs for the most mental health outcomes were not statistically significant (g=−0.04 to 0.39). Personalization and empathic response were 2 critical facilitators of efficacy. The longer duration of interaction with conversational agents was associated with the larger pooled effect sizes.

Conclusions

The findings show that CAIs are research-proven interventions that ought to be implemented more widely in mental health care. CAIs are effective and easily acceptable for those with mental health problems. The clinical application of this novel digital technology will conserve human health resources and optimize the allocation of mental health services.

Trial Registration

PROSPERO CRD42022350130; https://tinyurl.com/mvhk6w9p
Quality, Usability, and Effectiveness of mHealth Apps and the Role of Artificial Intelligence: Current Scenario and Challenges
Authors: Deniz-Garcia Alejandro , Fabelo Himar , Rodriguez-Almeida Antonio J , Zamora-Zamorano Garlene , Castro-Fernandez Maria , Alberiche Ruano Maria del Pino , Solvoll Terje , Granja Conceição , Schopf Thomas Roger , Callico Gustavo M , Soguero-Ruiz Cristina , Wägner Ana M ,   WARIFA Consortium
Published: March 2023

The use of artificial intelligence (AI) and big data in medicine has increased in recent years. Indeed, the use of AI in mobile health (mHealth) apps could considerably assist both individuals and health care professionals in the prevention and management of chronic diseases, in a person-centered manner. Nonetheless, there are several challenges that must be overcome to provide high-quality, usable, and effective mHealth apps. Here, we review the rationale and guidelines for the implementation of mHealth apps and the challenges regarding quality, usability, and user engagement and behavior change, with a special focus on the prevention and management of noncommunicable diseases. We suggest that a cocreation-based framework is the best method to address these challenges. Finally, we describe the current and future roles of AI in improving personalized medicine and provide recommendations for developing AI-based mHealth apps. We conclude that the implementation of AI and mHealth apps for routine clinical practice and remote health care will not be feasible until we overcome the main challenges regarding data privacy and security, quality assessment, and the reproducibility and uncertainty of AI results. Moreover, there is a lack of both standardized methods to measure the clinical outcomes of mHealth apps and techniques to encourage user engagement and behavior changes in the long term. We expect that in the near future, these obstacles will be overcome and that the ongoing European project, Watching the risk factors (WARIFA), will provide considerable advances in the implementation of AI-based mHealth apps for disease prevention and health promotion.
The Priorities of End Users of Emergency Department Electronic Health Records: Modified Delphi Study (Preprint)
Authors: Yip Matthew , Ackery Alun , Jamieson Trevor , Mehta Shaun
Published: March 2023

BACKGROUND

The needs of the emergency department (ED) pose unique challenges to modern electronic health record (EHR) systems. A diverse case load of high-acuity, high-complexity presentations, and ambulatory patients, all requiring multiple transitions of care, creates a rich environment through which to critically examine EHRs.

OBJECTIVE

This investigation aims to capture and analyze the perspective of end users of EHR about the strengths, limitations, and future priorities for EHR in the setting of the ED.

METHODS

In the first phase of this investigation, a literature search was conducted to identify 5 key usage categories of ED EHRs. Using key usage categories in the first phase, a modified Delphi study was conducted with a group of 12 panelists with expertise in both emergency medicine and health informatics. Across 3 rounds of surveys, panelists generated and refined a list of strengths, limitations, and key priorities.

RESULTS

The findings from this investigation highlighted the preference of panelists for features maximizing functionality of basic clinical features relative to features of disruptive innovation.

CONCLUSIONS

By capturing the perspectives of end users in the ED, this investigation highlights areas for the improvement or development of future EHRs in acute care settings.
Гліобластома: огляд літератури
Authors: Chaulagain Dipak , Smolanka V. , Smolanka A. , Havryliv T.
Published: March 2023

Гліобластома є найбільш агресивним типом пухлини головного мозку, визначена як астроцитома 4-го типу відповідно до 5-го видання класифікації пухлин центральної нервової системи Всесвітньої організації охорони здоров’я. Це рак, що починається в гліальних клітинах, які є підтримуючими клітинами мозку. Гліобластома є рідкісним типом пухлини головного мозку і становить близько 15 % усіх цих пухлин. Найчастіше вона зустрічається в дорослих віком понад 50 років, причому в чоловіків розвивається частіше, ніж у жінок. Симптоми гліобластоми можуть відрізнятися залежно від локалізації пухлини в головному мозку. Загальні симптоми включають головний біль, нудоту, блювання та зміни зору. Іншими симптомами можуть бути судоми, зміни в поведінці або особистості, а також труднощі з мовою або рухами. Стандартом лікування гліобластоми є поєднання хірургічного втручання, променевої та хіміотерапії. Хірургічне втручання є першим кроком у лікуванні, метою якого є видалення якомога більшої частини пухлини. Променева та хіміотерапія зазвичай використовуються для знищення будь-яких залишкових ракових клітин. Однак, незважаючи на ці методи лікування, прогноз при гліобластомі, як правило, поганий, більшість пацієнтів живуть менше двох років після встановлення діагнозу. Загалом гліобластома є дуже агресивною пухлиною головного мозку з поганим прогнозом. Стандартне лікування передбачає поєднання хірургічного втручання, променевої та хіміотерапії. Останні дослідження були зосереджені на розробці нових методів лікування, таких як цільова терапія та імунотерапія, що показали обнадійливі результати в клінічних випробуваннях.
FIRST PREDATION RECORD ON THE INVASIVE LAGOMORPH Lepus europaeus (Leporidae) BY Boa constrictor (Boidae) IN A SOUTHERN BRAZILIAN CERRADO PROTECTED AREA
Authors: Vieira-Alencar João Paulo dos Santos , Furtado Luciana de Oliveira , Felicio Giovana , Pinto-Coelho Daniela , Carmignotto Ana Paula
Published: March 2023

Natural history observations are essential to uncover unknown aspects of snake diets. Herein we describe a chance predation event upon the invasive Lepus europaeus by the snake Boa constrictor. Understanding interactions between native and alien species might shed light on the ecological impacts of invasive species, especially in protected areas.
Review of Inflammatory Markers in Metabolic Syndrome
Authors: Kumari Dr.T.M.J.Santhosha , Dr.G.Revathy  , Dr.Prabha
Published: March 2023

The conditions included in the definition of metabolic syndrome typically include central obesity (excessive fat accumulation around the waist), insulin resistance, hyperglycemia (elevated blood sugar levels), dyslipidemia (abnormal levels of lipids in the blood), and hypertension (high blood pressure). Having any three or more of these conditions is considered to be indicative of metabolic syndrome. Metabolic syndrome (MetS) is emerging as a major public health problem with pro-inflammatory changes leading to Insulin Resistance and Cardiovascular Disease (CVD) at a very young age. Metabolic syndrome (MetS) is a global health concern; metabolic syndrome is becoming more common in our country. It is found to be a risk factor for insulin resistance and abnormal adipose tissue . Clinical symptoms of the syndrome could include abdominal obesity, hypertension, diabetes, hypertriglyceridemia, and low HDL cholesterol. So far various studies have been conducted on the effect of inflammatory markers like Serum Uric acid (UA), serum homocysteine, Leptin, Lp(a) etc. Most of them have reported a positive correlation between these inflammatory markers and the various components of (MetS) like abdominal obesity, elevated Blood pressure, Fasting blood Glucose and Lipid profile abnormalities like elevated Triglycerides (TAG) and low High Density Lipoprotein-Cholesterol (HDL-C). Various studies have reported a positive correlation between serum uric acid and Serum Homocysteine and Lp(a) in causing endothelial dysfunction and premature Cardiovascular events. Hence a review of the studies pertaining to the various inflammatory markers was done. There was an association of various inflammatory markers like uric acid, homocysteine, MDA, lipoprotein and others. More awareness must be created even at the high school level regarding the ill effects of sedentary lifestyle the likely hood of metabolic syndrome. An early identification of surging biomarker levels in high-risk children may find new cases at an earlier stage to prevent upcoming diabetes mellitus and its complications.
Kinetic modelling and process optimization of textile effluent treatment with bacterial gamma polyglutamic acid
Authors:   Department of Biotechnology, K. S. Rangasamy College of Technology, Tiruchengode-637 215, India, Mohanraj R. , Gnanamangai B.M. ,   Department of Biotechnology, K. S. Rangasamy College of Technology, Tiruchengode-637 215, India, Ramesh K. ,   amilnadu Water Investment Company Limited, Tiruppur-641 602, India, Ponmurugan P. ,   Department of Botany, Bharathiar University, Coimbatore-641 046, India
Published: March 2023

Aim: The present study aims to synthesize gamma poly glutamic acid from the optimized starch-based glutamate-dependent medium for wastewater treatment with kinetic studies for an effective decolorization process. Methodology: Microbial coagulant (γ-PGA) was synthesized from the optimized glutamate-dependent medium with sago as a substrate and Bacillus subtilis as fermenter. Synthesized γ-PGA was harvested by ethanol precipitation and lyophilization method. The presence of γ-PGA was determined by UV-visible spectrum and ninhydrin analysis and its flocculating activity was screened by ninhydrin assay. Harvested γ-PGA was treated with different types of wastewater samples (Textile, tannery, dairy and sewage) in the preliminary screening. Process optimization was performed to screen the maximal decolorization for textile effluent (light and dark color). The physical and chemical characterization of treated wastewater samples with kinetic studies was performed to improve the treatment process. Results: The synthesized γ-PGA weighed as 41.20 g l-1 from the fermented medium and its presence was confirmed by characterization techniques. The flocculating activity of synthesized γ-PGA was 40.56 and 58.78 % against the kaolin suspension. The maximal decolorization percentage was 59.58% for γ- PGA treatment against textile effluent. The significance of optimized parameters such as pH, temperature, rotation speed and contact time were determined in the treatment of textile effluents (light and dark color) with maximal reduction of solids profile COD and BOD concentration. Kinetic studies revealed that the isotherm Langmuir isotherm was fit for the experimental data with R2 as 0.9943, 0.9692 and Pseudo second order fitted with R2 as 0.9871 and 0.9594 respective to light and dark color effluent. Interpretation: This study confirmed the maximal yield of γ-PGA from a sago-based glutamate-dependent medium and revealed its effective flocculating and decolorization activity against textile effluent which suggest them as a better alternative coagulants. Key words: γ- PGA, Bacillus subtilis, Kinetic modelling, Process optimization
Deciphering variability for heat tolerance index in maize hybrids and identification of stress resilient heterotic combinations
Authors:   Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana-141 004, India, Sandhu S. , Yousuf N. ,   Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana-141 004, India, Singh G. ,   Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana-141 004, India, Kumar M. ,   Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana-141 004, India
Published: March 2023

Aim: High temperature at any critical stage for a prolonged duration is documented to negatively affect the growth and yield related processes in maize. Therefore, the present study was planned to identify resilience of different heterotic combinations to heat stress under field conditions. Methodology: A set of 20 parental lines were used as parents and 21 single cross hybrids raised in kharif 2020 using 16 lines as female parent and four lines as male parent along with three commercial checks using randomized block design under two regimes: Normal Sownin mid of February, i.e., timely sown condition (spring season crop) and late sown in mid of March (heat stress crop). Data was recorded for yield and its contributing traits. Results: Heat stress led to early onset of flowering, thus resulting in shortening of vegetative phase. Consequently, days to grain filling period was found to be reduced (84-106 days) under late sown as compared to 100-123 days under normal sown condition. Amongst the top performing six hybrids in both normal sown and late sown conditions, three hybrids were common viz., JH 20003, JH 20015 and JH 20018, though with different ranking, inferring their wider adaptability and tolerance to heat stress. Under late sown conditions, days to grain filling (r2=0.55) and thousand seed weight (r2 =0.50) showed significantly positive correlation with grain yield while as highly significant and negative association was observed between anthesis silking interval and grain yield (r2 = -0.76). Among the 21 hybrids, three hybrids (JH 20001, JH 20004, and JH 20015) showed greater potential under heat stress conditions on the basis of yield performance under stress, percent yield reduction and heat tolerance index. Interpretation: Based on multiple selection criteria, three hybrids viz., JH 20001, JH 20004, and JH 20015 were suggested for commercial utilization after validation. This study also led to identification of donor inbreds which can contribute to breeding for heat stress tolerance. Key words: Grain yield, Heat tolerance index, Heat stress, Maize, Percent yield reduction
Bioactive properties of brown seaweed, Sargassum wightii and its nutritional, therapeutic potential and health benefits: A review
Authors:   Section Zoology, School of Sciences, Maulana Azad National Urdu University, Hyderabad-500 032, India, Afreen A.B. , Rasool F. ,   Section Zoology, School of Sciences, Maulana Azad National Urdu University, Hyderabad-500 032, India, Fatima M. ,   Section Zoology, School of Sciences, Maulana Azad National Urdu University, Hyderabad-500 032, India
Published: March 2023

Seaweed, Sargassum wightii is a brown macroalgae (Phaeophyceae) rich in bioactive compounds such as fucoxanthin, flavonoids, sterols, sulfated polysaccharides, polyphenols, proteins and beta-carotene pigments. The purpose of the present review is to focus and discuss the usefulness of bioactive compounds of S. wightii to humans and animals as they exhibit diverse therapeutic activities like analgesic, anti-inflammatory, antioxidant, anti-cancer, anti-microbial, anti-tumor, immune-modulatory, anti-coagulant, hepatoprotective, anti-viral activities, etc. The present review clarifies the nutritional, therapeutic potential and health benefits of brown seaweed algae. Nowadays, attention is being paid on the use of seaweeds for human health, food, cosmetics, energy, fertilizer and in the field of aquaculture, poultry and other industries due to their nutritive value. It is being utilized in the wastewater treatments to reduce nitrogen and phosphorus-containing compounds. This review is an attempt to highlight the nutritional and commercial value of Sargassum wightii, due to its bioactive compounds related to health status and disease prevention in humans and animals. Key words: Bioactive compounds, Phaeophyceae, Seaweeds, Sargassum wightii
Potential application of fungal biosorption and/or bioaccumulation for the bioremediation of wastewater contamination: A review
Authors:   Centro de Investigación en Biotecnología Aplicada (CIBA), Instituto Politécnico Nacional. Tlaxcala, 90700, Mexico, Bibbins-Martínez M. , Juárez-Hernández J. ,   Centro de Investigación en Biotecnología Aplicada (CIBA), Instituto Politécnico Nacional. Tlaxcala, 90700, Mexico, López-Domínguez J.Y. ,   Polytechnic University of Puebla, Puebla, 72640, Mexico, Nava-Galicia S.B. ,   Centro de Investigación en Biotecnología Aplicada (CIBA), Instituto Politécnico Nacional. Tlaxcala, 90700, Mexico, Martínez-Tozcano L.J. ,   Centro de Investigación en Biotecnología Aplicada (CIBA), Instituto Politécnico Nacional. Tlaxcala, 90700, Mexico, Juárez-Atonal R. ,   Centro de Investigación en Biotecnología Aplicada (CIBA), Instituto Politécnico Nacional. Tlaxcala, 90700, Mexico, Cortés-Espinosa D. ,   Centro de Investigación en Biotecnología Aplicada (CIBA), Instituto Politécnico Nacional. Tlaxcala, 90700, Mexico, Díaz-Godinez G. ,   Research Center for Biological Sciences, Autonomous University of Tlaxcala. Tlaxcala, 90000, Mexico
Published: March 2023

The environment pollution or contamination is a serious problem, a great deal of research is being undertaken to combat contaminants such as xenobiotic and recalcitrant compounds, particularly heavy metals, dyes,phenolic compounds and other recalcitrant pollutants produced by a wide range of industrial activities. These compounds have an adverse impact on the environment, particularly when generated by industrial processes and then disposed off without adequate treatment. Mycoremediation is defined as the use of fungi for bioremediation, especially degradation or retention of contaminants. Biosorption and bioaccumulation are two of the mechanisms by which fungi remove contaminants through mycelium. In many cases, these processes involve metabolization and even mineralization of these contaminants, corresponding to a biological contaminant removal system with great potential for use in bioremediation processes. The present review describes the unique characteristics of fungal mycelium that make it a biomaterial with potential applications in various fields of biotechnology, specifically evaluating its biosorption/bioaccumulation properties and potential application for the bioremediation of different water-borne contaminants. This review focus on the researches conducted on the bioremediation of inorganic and organic pollutants, the mechanisms involved in the process, and the main environmental factors affecting it. Moreover, kinetics and equilibrium modeling of the removal efficiency achieved via biosorption/bioaccumulation is analyzed in order to better understand these processes and overcome some of the technical barriers to their large-scale application in the mycoremediation of wastewater. Key words: Bioaccumulation, Biosorption, Fungi, Mycoremediation, Xenobiotics
Ensino híbrido mão na massa: aprendizagem com alunos mais ativos
Authors: Valente José Armando
Published: March 2023

O ensino híbrido tem sido descrito desde o início dos anos 2000 como a combinação de atividades educacionais presenciais e on-line. No entanto, o foco das atividades online, está centrado no uso de vídeos que o professor disponibiliza e/ou em materiais digitais que o aluno encontra na internet. A questão a ser discutida é: como o ensino híbrido pode criar oportunidades para a construção de conhecimento? Este artigo tem como objetivo apresentar e discutir a abordagem do ensino híbrido mão na massa, que incorpora aos modelos do ensino híbrido o desenvolvimento de um produto. Além do produto construído pelo aluno, a proposta enfatiza atividades como curadoria, reflexão sobre o produto construído e aprofundamento conceitual. A metodologia é baseada em pesquisa documental e bibliográfica, bem como em dados coletados na participação da live FuturED – LiveZAÇO Maker. A análise dos artigos e dos dados coletados permitem concluir que somente criar um produto não necessariamente indica que o aluno construiu conhecimento. Assim, as atividades de curadoria, reflexão e aprofundamento são fundamentais para auxiliar o aluno no processo de construção de conhecimento conceitual a partir do saber fazer.