bluuebunny/crossref_metadata_2025 huggingface dataset:
The Analysis of Psychological Factors of Compliance to Treatment of Persons with the Kidney Stone Disease
Authors:   Saint Petersburg State University, Zaitseva D. V.
Published: December 2022

The issue of compliance to treatment is drawn a lot of attention to nowadays due to the shift to the bio-psycho-social paradigm. Multiple studies stress the role of psychological factors of compliance; in the clinic of the kidney stone disease though these factors are understudied. The study has found that at the hospital treatment stage persons have high and medium level of compliance to treatment. The factors influencing the level of compliance are the type of attitude to the disease and the level of health frustration. Thus, the patients with a high level of compliance tend to have adaptive reactions to a disease, while those with a medium level show maladaptive reactions. The patients with a high level of compliance show social frustration, which is significantly lower according to the indices of frustration of one’s own health and of socio-economic status.
The Process of Becoming Aware of a Meaning in the Light of the Positive and Negative Choice Conception as a Way to Resolve Some Inconsistencies in Models Based on the Activation Hypothesis Approach
Authors:   Saint Petersburg State University, Pilatova O. I.
Published: December 2022

Studies indicate that before some meaning of the incoming information has been cognized, many other possible interpretations are actualized but not cognized. Most models describing this process are based on the activation metaphor and the idea of cognitive threshold: activation of the meaning related to the context intensifies, while other meanings are deactivated and do not overcome the threshold. When summarizing findings of the experiments relevant to this issue, however, there are some inconsistencies logically conflicting with this mechanism. The article presents an alternative approach to understanding this process, according to which unconscious meanings retain their actualization after everything that occurs is cognized as well. They are actively kept from being cognized ensuring this way coherence of the context being cognized and specifying chosen meanings
Disability, Inclusion and Language-in-Education Policy in the Global South: The Colombian Context
Authors: David Rosa Dene , Brown Kimberley
Published: December 2022

This paper calls for a shift related to English language-in-education policy and inclusive education initiatives in Colombia to ensure that English language learners with disabilities receive equitable and inclusive classroom instruction that is context-appropriate. We call for English language initiatives and policies to draw from theories and practices from both the Global South and the Global North in order to teach towards inclusive education. Trends in both English language teaching and inclusive education have drawn upon the Global North for solutions, which cannot be systemised to fit one international standard. Instead, using the Colombian context as an example, the present paper suggests a localised approach to meeting the educational needs of English language learners that incorporates inclusive education at the institutional level. This model would favour the work of scholars within the region to ensure that all students receive equitable classroom instruction that builds in Global South epistemologies and localised ways of knowing.
Dyslexia and English as a Foreign Language in Norwegian Primary Education: A Mixed Methods Intervention Study
Authors: Flaten Jarsve Christopher , Tsagari Dina
Published: December 2022

Τhe current study explored the effect of specific teaching accommodations for English language learners with dyslexia in a Norwegian primary school. Specifically, this single group intervention project investigated the impact of a range of multisensory techniques on spelling skills and motivation. Participants included a special education teacher and five dyslexic pupils from the fifth and sixth grades. Pre- and post-tests were administered to observe development in spelling, while data were also collected via a pupil evaluation questionnaire and a teacher interview after the intervention. The findings revealed that the intervention was quite successful. The group exhibited substantial differences in mean scores between the pre- and post-test. However, there were individual differences in scores and comorbid disorders appeared to impact the effectiveness of the intervention. Nonetheless, all of the pupils reported gains in their motivation and improvement in their attitude towards learning English, which was confirmed by their special education teacher. The paper concludes by offering specific didactic suggestions regarding accommodations for English language learners with dyslexia.
Нечітке моделювання запиленості атмосфери в місті Києві
Authors: Божко Костянтин Михайлович , Морозова Ірина Володимирівна
Published: December 2022

На основі моделі нечіткої логіки розраховано індекс запиленості атмосферного повітря в місті Києві за результатами вимірювання концентрації твердих часток типу РМ1, РМ2.5 і РМ10 станціями екологічного моніторингу. Модель має 301-бальну шкалу, яка на своїх границях є сумісною зі шкалою визначення індексу якості повітря AQI від агенції ЕРА (США). Модель побудована за алгоритмом Мамдані, має три входи і один вихід із трьома функціями належності кожній. Вхідні дані є значеннями концентрації твердих часток типу РМ1, РМ2.5 та РМ10. База нечітких правил має 27 формул нечіткого виведення. Модель розроблена в пакеті MATLAB і може бути основою експертної системи з оцінювання рівня небезпеки для здоров’я людини за результатами вимірювання концентрації твердих часток, перш за все  фракцій із малою дисперсністю.
Вплив технології відпрацювання розвалу гірської породи на розміри та форму розвалу негабариту
Authors: Коробійчук Валентин Вацлавович , Підвисоцький Віктор Тодосійович , Шамрай Володимир Ігорович , Качуровський Михайло Валентинович , Соколовський Володимир Олегович
Published: December 2022

У публікації розглянуто дві схеми відпрацювання розвалу гірської породи механічною лопатою з об’ємом ківша 5 м3 в умовах Лезниківського кар’єру. Фотогранулометричний аналіз підірваної гірничої маси проводиться за допомогою програмного забезпечення WipFrag 2010 Advanced Tutorial. Розвал гірської породи розділявся на заходки і визначалася кількість негабариту, яка припадає на кожну заходку екскаватора. Середня ширина розвалу гірської породи становить 55–65 м. При торцевій схемі відпрацювання найменша кількість розпушеної породи припадає на першу заходку 12–18 %. На інші дві заходки припадає приблизно однакова кількість гірської породи (37–43 % та 42–49 %). Було встановлено залежність ширини розвалу гірської породи від ширини заходки екскаватора та положення цієї заходки. Також розглянуто панельний спосіб відпрацювання розвалу гірської маси, який застосовується при широких робочих майданчиках або при розробці невеликих за фронтом робіт кар’єрів. Ширина розвалу має форму в вигляді трапеції та змінюється залежно від відстані, на яку просунувся екскаватор вглиб вибою. При цьому радіус черпання не впливає на ширину розвалу негабариту. Було встановлено залежність ширини розвалу гірської породи від ширини заходки при панельному способі відпрацювання розвалу гірської породи.
Супутнє видобування блоків природного каменю в умовах щебеневого кар’єру
Authors: Коробійчук Валентин Вацлавович , Темченко Анатолій Георгійович , Шамрай Володимир Ігорович , Іськов Сергій Станіславович , Дубінчук Богдан Володимирович
Published: December 2022

Більшість щебеневих гранітних кар’єрів в Україні має ділянки із низькою тріщинуватістю, що дозволяє вести видобуток блоків природного декоративного каменю, при чому на деяких кар’єрах ці ділянки є значні за об’ємом, наприклад, як на Лезниківському кар’єрі. Перспектива супутнього видобутку блоків у щебеневих кар’єрах є економічно обґрунтованою, оскільки вартість одного куба щебню (8–10 дол. США) в десятки разів менше за вартість одного куба блока природного декоративного каменю (180–600 дол. США) при майже однакових затратах на видобуток. При супутньому видобуванні блоків можливо залучити існуюче видобувне обладнання щебеневого кар’єру, що зменшить витрати на технологічні комплекси гірничого підприємства. В публікації розроблена схема для роботи машини для різання каменю PILEMASTER RS15. Екскаватор з дисковою пилою може відпрацьовувати уступ як з підошви уступу, 1’ так і з покрівлі. Робочі параметри гідравлічних екскаваторів дозволяють розробляти уступи висотою до 10 м з підошви, вище 10 м з двох положень – з підошви та покрівлі уступу. Запропоновано технологічну схему супутнього видобутку блоків природного каменю на ділянках, які розміщені в межах робочої зони щебеневої дільниці кар’єру. У технологічній схемі А виїмки дисковою машиною природних блоків на стадії видобутку корисної маси з масиву закладено принцип поштучного оконтурювання блоків у виїмкових смугах уступу. Схема В за технологією відокремлення блоків з масиву така сама як схема А. Але роботи ведуться зверху вниз.
Застосування автоматизованих та інформаційних систем з цифровими зображеннями при відкритій розробці родовищ природного каменю
Authors: Подчашинський Юрій Олександрович , Кирилович Валерій Анатолійович , Лугових Оксана Олександрівна
Published: December 2022

У статті розглядаються можливості застосування автоматизованих та інформаційних систем з цифровими зображеннями для розв’язання практичних задач, що пов’язані з видобуванням та обробкою природного каменю. Комп’ютеризована обробка та аналіз зображень поверхонь природного каменю та промислових виробів з нього дозволяє вимірювати характеристики кольорової текстури цих поверхонь, а також геометричні розміри та кути виробів по зовнішньому контуру. Отримані результати будуть корисними для визначення механічних характеристик природного каменю на ділянках родовищ, що розробляються чи плануються до розробки, для дослідження фізико-механічних характеристик гірських порід, що обумовлені їх кристалічною будовою, для контролю якості лицьової поверхні і геометричних розмірів промислових виробів з природного каменю. Наведено приклад експериментальних досліджень та оцінки складу й будови зразків габроїдної породи. Наведено й систематизовано основні напрями використання автоматизованих та інформаційних систем з цифровими зображеннями для отримання вимірювальної інформації про характеристики зразків та виробів з природного каменю в гірничо-геологічній галузі. Це дозволяє підвищити ефективність гірничих робіт з відкритої розробки родовищ природного каменю, точність визначення характеристик зразків та виробів, підвищити якість та конкурентоспроможність промислової продукції підприємств з видобування й обробки блочного природного каменю.
Особливості торцевого фрезерування сплавів Ni-Ti з ефектом пам’яті форми
Authors: Балицька Наталія Олександрівна
Published: December 2022

У роботі представлено огляд сучасних наукових досліджень процесу механічного оброблення сплавів Ni-Ti (нітинолів). Ці функціональні матеріали зазнають мартенситних перетворень, які визначають їх особливі фізико‑механічні властивості (ефект пам’яті форми, надпружність, високу демпфуючу здатність та ін.). Описано фізико- та термомеханічні властивості сплавів Ni-Ti з ефектом пам’яті форми, а також явища, які супроводжують процес різання та обумовлюють низьку оброблюваність цих матеріалів. Проведено огляд раціональних інструментальних матеріалів, режимів різання та умов оброблення, які пропонуються сучасними практиками та дослідниками. Проаналізовано результати відомих робіт із визначення сил різання, температур, стійкості інструментів, шорсткості та мікротвердості оброблених поверхонь, глибини зміцненого шару та залишкових напружень. Обговорюються результати експериментальних досліджень процесу торцевого фрезерування нітинолів в умовах сухої, кріогенної обробки та обробки із мінімальним змащуванням. Виявлено недостатність ґрунтовних і масштабних досліджень процесів торцевого фрезерування сплавів Ni-Ti з ефектом пам’яті форми різних марок для призначення умов їх гарантовано ефективного оброблення. Обґрунтована необхідність подальших наукових пошуків перспективних шляхів підвищення ефективності торцевого фрезерування нітинолів із забезпеченням високої якості поверхневого шару виробів.
Автоматизована система керування сушильною камерою періодичної дії
Authors: Євсеєнко Олег Миколайович , Ольшевський Андрій Вікторович , Лещенко В’ячеслав Михайлович
Published: December 2022

Стаття присвячена пошуку рішень для впровадження алгоритмів керування температурою об’єктів у сушильній камері періодичної дії. Розроблені алгоритми керування вимагають апаратної платформи, на якій можливе впровадження та побудова програмних моделей. Аналіз літературних джерел показав, що тема сушіння деревини є актуальною в усьому світі через складну структуру об’єкта керування й потенційну можливість економії енергоресурсів. Через складність об’єкта керування та необхідність забезпечення безперервної та стабільної якості сушіння виникає потреба побудови автоматизованих систем для впровадження нових алгоритмів керування. Вимогами до побудови системи є: безпечність, можливість задання налаштувань, робота в різних режимах, діагностування несправностей. Неправильний процес сушіння може призвести до браку всієї партії деревини, а отже, і до економічних втрат. Серед пропонованих рішень – побудова математичних моделей, використання регуляторів з прогнозуванням, апаратні підходи. З’ясовано, що складність об’єкта керування обумовлена початковим рівнем вологості, пористою структурою, залежністю від типу деревини та розміру її поперечного зрізу. Для оцінки ефективності впроваджених алгоритмів керування орієнтуються на такі фактори: швидкість сушіння, відсутність дефектів, низьке споживання енергії.  Розроблено перелік вхідних-вихідних сигналів, який показав, що для побудови системи керування необхідні датчики температури, вологості, стану роботи виконавчих пристроїв та самі виконавчі пристрої. Проведено синтез обладнання та побудовано структурну схему підключення. Описано алгоритм роботи об’єкта управління, який складається з підготовчої частини, роботи в автоматизованому або ручному режимі. Окрему увагу приділено опису аварійних ситуацій, роботі системи під час їх виникнення та логуванню подій.
INFLUENCE OF PSYCHOLOGICAL FEATURES OF THE DESTINATION REGION POPULATION ONTO MIGRATORY PROCESSES IN RUSSIA
Authors:   Institute of Psychology of Russian Academy of Sciences, Sugonyaev Konsatantin V.
Published: December 2022

Despite growing interest to clarification of role of psychological factors in migratory processes, this domain is typically studied at the individual level. The current study examines the association between personality and intellect of the destination region in Russia on the one hand and migratory processes in this region. Given the lack of any preceding aggregate-level research of psychological characteristics in context of migratory processes in Russia, the study was explanatory in this part. The estimates of regional intelligence and personality were calculated using data collected during voluntary online testing of the male respondents representing all subjects of the Russian Federation, in 2012-19. Regional net migration indices were calculated on the basis of data from the Russian Federal Service of State Statistics «Regions of Russia» by means of averaging of annual indices for the same period. Seven regions were excluded for sound reasons and four subjects the Russian Federation were pooled by pairs. It reduced number of regions to 76 and number of respondents to 206,363. Correlation and stepwise multiple regression procedures were used to determine relations between net migration and the psychological variables. The results suggest that migration across regions is significantly related to differences in some psychological features of destination regions: the share of variance accounted for net migration by regression model based on five personality traits is about 45%. In spite of the fact that the intelligence significantly correlates with a net migration, its contribution to model did not reach significance. It is established that net migration is higher in regions where population is more assertive, self-controlled and less antagonistic in average; style of responding on questionnaire items in such regions tended to be more discriminative and open. Future research is needed to better understand and measure the impact of more diverse spectrum of aggregated psychological, social, economic and geographical features on migratory processes in regions.
TERRORISM IN SOCIETY AS AN OBJECT OF SOCIOLOGICAL RESEARCH AT THE BEGINNING OF THE XXI CENTURY
Authors:   Moscow State Linguistic University, Lapshov Valery A. ,   Security Problems Research Center of the Russian Academy of Sciences
Published: December 2022

The article examines the relevance of the study of terrorism at the beginning of the XXI century. When studying terrorism in society as an object of sociological research, the method of content analysis of articles posted in the Russian scientific electronic library eLIBRARY.RU and a number of foreign scientific journals was used, which was carried out in three stages. At the first stage, the objects of analysis were: domestic scientific journals included in the List of peer-reviewed scientific publications approved by the order of the Ministry of Education and Science of Russia dated February 12, 2019 No. 21-r; as well as international scientific journals on terrorism. In these sources, a search was carried out for documents containing in their title the semantic unit "terrorism", as well as semantic units related to various types of terrorist activities. As a result of the first stage, about 160 scientific journals were selected that publish materials related to the problem of terrorism as an object of research. At the second stage of the study, the data obtained were analyzed quantitatively and qualitatively. The main objectives of the second stage were the analysis and systematization of indicators and criteria of terrorism as an object of sociological research. To achieve the set goals from the general population formed at the first stage, scientific journals of a sociological orientation were selected, namely, one domestic — "Sociological Research", and three foreign — "Studies in Conflict and Terrorism", "Terrorism and Political Violence" and "Post-Soviet Affairs", which formed the basis of this study. At the third stage, about 1,500 articles containing the word “terrorism” and its synonyms in the title were analyzed in the selected journals, based on the methodology of qualitative content analysis. The system of semantic units can be presented in the form of two blocks. First, a complete list of words related to terrorism was compiled. Secondly, a preliminary analysis of the main synonyms for the word "terrorism as an object of sociological research" was made. From the entire general population obtained at the second stage of the study, publications were selected containing highlighted semantic categories in the titles of works. Thus, after analyzing all publications, about 20 scientific papers were selected that met the search criteria. This approach made it possible to reflect the idea of terrorism in society as an object of sociological research.
PERSONAL AND INTELLECTUAL CHARACTERISTICS OF THE REPUTATION OF AN EMPLOYEE IN THE CIVIL SERVICE AS AN ELEMENT OF HUMAN CAPITAL
Authors:   N.N. Zubov’s State Oceanographic Institute, Protsenko Sergey A. , Tsaplin Evgeny V. ,   Administration of Tyumen city
Published: December 2022

The article presents a study that examines the factors of intelligence and personality of employees that affect their reputation. Respondents: 1,047 municipal employees. Evaluation objects: 227 managers. The sociometry method was used to study the reputation of employees. The factors of intelligence were investigated by the method of "Standardized Intellectual Potential Test" (TIPS). Personal factors were investigated by the method of "11 personal factors" (11LF). The data were processed by the t-Student criterion. Differences in the severity of intellectual and personal factors among managers with different reputations were revealed. Recommendations on the introduction of reputation management technologies in the public service are given.
Main Directions of Medical and Psychological Rehabilitation of Combatants
Authors:   National University of Pharmacy, Department of Physiology and Pathological Physiology. 53, Pushkinska Str., Kharkiv 61002, Ukraine, Kotvitska A. A. , Kononenko N. M. , Chikitkina V. V.
Published: December 2022

The war in Ukraine actualized the problem of post-traumatic stress disorder. Comprehensive rehabilitation of combatants after the end of hostilities, that is, after the termination of the stressor, is of particular importance for society. Reducing the impact of the consequences of traumatic stress on somatic health and preventing psychosomatic pathology in these patients is an important task of medicine. The purpose of the study was to analyze the main directions of medical and psychological rehabilitation of combatants and measures to improve them. Materials and methods. A review of the literature in specialized publications and the Internet was carried out. Results and discussion. Medical and psychological rehabilitation of combatants should include several areas: diagnosis of the syndrome of socio-psychological maladaptation; psychological counseling; psychological correction; training in self-regulation skills; socio-psychological trainings; assistance in professional self-determination, career guidance for retraining and subsequent employment. The medical and psychological rehabilitation of combatants should be based on the main provisions of the integrative coping concept, according to which overcoming stress is a process in which an individual attempts to change or eliminate the problem, to reduce its intensity by changing their point of view on it, to ease its impact by distracting themselves from something or using other various coping methods. Conclusion. The results obtained clearly proved that today the rehabilitation of only the physical condition of patients is no longer relevant, since without taking into account the psychological status of the individual, its social adaptation, it is impossible to talk about the full functioning of the individual. All combatants will have to go through a period of social and psychological rehabilitation. The implementation of the Concept of the State Target Program for the physical, medical, psychological, social rehabilitation and professional readaptation of combatants requires the implementation of organizational and legal measures related to the conduct of targeted and coordinated actions on the part of government bodies, executive authorities, local governments, non-state institutions and organizations, and on a nationwide scale should provide medical, social and economic efficiency. The system of providing medical and psychological assistance and rehabilitation of combatants actions in terms of material, technical and personnel support should be considered as a component of the national security of the state
Evolution of Treatment Tactics for Patients with Trunk Lesions of Coronary Arteries
Authors:   National Institute of Cardiovascular Surgery named after MM Amosova NAMS, Department of X-ray Surgical Methods of Treatment of Heart and Blood Vessels Diseases. 6, Amosov St., Kyiv 03038, Ukraine, Levchyshyna O. V. , Aksyonov E. V. , Salo S. V.
Published: December 2022

Damage to the trunk of the left coronary artery is the most dangerous manifestation of coronary atherosclerosis. Mortality with this type of lesions occurs by 3–4 times more often compared to lesions of other segments of coronary arteries. On the basis of previous clinical studies demonstrating advantages of coronary artery bypass grafting over drug therapy in terms of patient survival, coronary artery bypass grafting has long been considered the gold standard for the treatment of these lesions. The purpose of the work was to study the literature data on the evolution and peculiarities of the choice of methods of surgical treatment of coronary heart disease in patients with severe lesions of the trunk of the left coronary artery. Results and discussion. Along with the improvement of endovascular instrumentation, stenting procedures, antithrombotic agents, as well as concomitant drug therapy, percutaneous coronary interventions for lesions of the left trunk are becoming more and more widespread and show favorable clinical results in these patients. This is evidenced by the data of many randomized multicenter studies (SYNTAX, EXCEL). Based on the results of these studies, ESC/EACTS approved the following guidelines for myocardial revascularization in 2018. Percutaneous coronary interventions are indicated in the case of damage to the left trunk with scores on the SYNTAX scale less than 22 – class I, scores on the SYNTAX scale 23–32 – class IIa, and scores on the SYNTAX scale greater than 32 – class III. However, it is worth noting that both the American and the European guidelines recommend a discussion by a team of endovascular surgeons, cardiologists and cardiac surgeons (Heart Team) when choosing a treatment strategy for coronary artery disease patients with lesions of the trunk of the left coronary artery. Since the data of many studies on the treatment of patients with lesions of the trunk of the left coronary artery remain quite contradictory and ambiguous. Conclusion. Current literature data have shown that left coronary artery stenting is a fairly safe procedure, with a high rate of immediate success, low mortality, and few complications, especially in low-risk surgical patients. The use of stents with medical coating made it possible to reduce the frequency of repeated interventions to 10–12%. A number of issues remain, the solution of which would allow optimizing the application of this technique. These include: development of indications for surgical or endovascular treatment of lesions of the left coronary artery trunk, optimization of stenting techniques, assessment of the significance of concomitant pathology in the effectiveness of treatment of patients with lesions of the left coronary artery trunk
The Effect of Polyphenols on Lipid Peroxidation and the Antioxidant System in the Submandular Salivary Glands during Combined Administration of Alcohol and S. typhi Lipopolysaccharide
Authors:   Petro Mohyla Black Sea National University. 10, 68 Desantnykiv Str., Mykolaiv 54003, Ukraine, Kozaeva R. S. , Klymenko M. O.
Published: December 2022

The purpose of the study was to study the effect of polyphenols (curcumin, epigallocatechin-3-gallate, and quercetin) on indicators of lipid peroxidation and antioxidant protection in the submandibular salivary glands of rats with alcohol damage against the background of lipopolysaccharide-induced systemic inflammatory response. Materials and methods. The studies were conducted on 35 rats of the Wistar line weighing 205–220 g, divided into 5 groups of seven animals in each: the 1st group (control) included animals receiving isotonic sodium chloride solution intragastrically twice a day; the 2nd group included rats exposed to alcohol (in a dose of 24 mg/kg intragastrically through gavage twice a day) for last 2 weeks during lipopolysaccharide-induced systemic inflammatory response; the rats of the 3rd, 4th and 5th groups were exposed to alcohol during lipopolysaccharide-induced systemic inflammatory response, which also received polyphenols, administered intragastrically: curcumin (diferuloylmethane, in a daily dose of 200 mg/kg), epigallocatechin-3-gallate (in a daily dose of 40 mg/kg), quercetin (in a daily dose of 200 mg/kg), respectively. The level of lipid peroxidation in the tissues of the submandibular salivary glands was assessed by the formation of compounds that react with thiobarbituric acid. The state of antioxidant protection was assessed by the increase in the concentration of thiobarbituric acid-active products during a 1.5-hour incubation in iron ascorbate buffer solution, as well as by the activity of superoxide dismutase. Results and discussion. When using curcumin under the experimental conditions, the concentration of thiobarbituric acid-reactants in the homogenate of submandibular salivary glands before and after incubation was 59.3 and 55.7% inferior to the corresponding results of the 2nd group, when prescribing epigallocatechin-3-gallate – by 55.7 and 51.2%, quercetin – by 67.0 and 61.0%, respectively. This was accompanied by a probable increase in the activity of superoxide dismutase in the tissues of the submandibular salivary glands. Conclusion. The use of curcumin and bioflavonoids (epigallocatechin-3-gallate and quercetin) under conditions of combined administration of 40% ethanol and S. typhi lipopolysaccharide significantly limits the development of lipid peroxidation in the tissues of the submandibular salivary glands, increases their antioxidant potential, superoxide dismutase activity
Nummular Headache (Clinical Observation, Discussion)
Authors:   Poltava State Medical University, Department of Neurological Diseases. 23, Shevchenka Str., Poltava 36011, Ukraine, Delva I. I.
Published: December 2022

The purpose of the study was to show the importance of using international diagnostic criteria of headache in neurological practice through description of clinical case of nummular headache. Materials and methods. Complaints, medical history, life history, results of objective and neurological examination, data of laboratory and instrumental research methods in a patient with nummular headache. Results and discussion. Patient G., 53 years old, complained of constant, dull, local, moderate pain in the right parietal area. The headache appeared gradually 5–6 months ago, without any evident triggers. Patient denied autonomic trigeminal signs, nausea, photo- and phonophobia. Painkillers intake was accompanied by a temporary slight decrease of headache intensity. At examination patient pointed to local pain area in the right parietal region that had diameter about 3 cm, rounded shape and clear borders. Neurological status – without abnormalities, except for hyperalgesia in the pain area. The skin and hair in the pain area were not changed, touching the skin in this place caused unpleasant feeling. General and biochemical blood tests, blood glucose, general urine analysis were within reference values; magnetic resonance imaging of the brain was without abnormalities; magnetic resonance imaging of the cervical spine showed osteochondrosis, protrusion of intervertebral discs C5-C6, C6-C7. Additional examination was recommended to the patient: computer tomography of the head (skull bones were unchanged), consultation of a dermatologist (no pathology was found). Finally, it was concluded that patient's condition, according to the international classification of headache disorders of the 3rd revision, corresponds to the diagnosis of “nummular headache”. Gabapentin was prescribed 300 mg per day, followed by increasing of the drug dose by 300 mg every 3 days to a daily dose of 1200 mg or until a significant reduction (disappearance) of headache occurred at the lower gabapentin doses. After 1 week of gabapentin taking, patient reported significant decrease in headache intensity at a daily dose of 600 mg with subsequent headache disappearance at a daily dose of 900 mg. It was recommended to continue gabapentin taking at a dose of 900 mg per day for the next 3 months. After 3 months, the patient reported no headache during the entire period of gabapentin usage. It was recommended to reduce the daily dose of gabapentin by 300 mg every 5 days until the headache recurs or until total discontinuation of drug intake. 1 month later the patient reported no headache since stopping gabapentin intake. Conclusion. Neurologists need to know and actively use in their practice the international diagnostic criteria of nummular headache, that is the basis of adequate management of this rare primary headache
Treatment of Stress-Induced Disorders in Women with Uterus Leiomyoma on the Background of Hormone Therapy during the Wartime
Authors:   State scientifically institution Scientifically-practical center prophylactic and clinical medicine State Governors President’s Affair. 5, Verkhnja St., Kyiv 01014, Ukraine, Doroga O. P. , Ovodyuk N. M. , Shestak N. V. , Hlabets S. P. , Matsyshyn V. S.
Published: December 2022

The purpose of the study was to assess psychosomatic changes and determine clinical and laboratory indicators in women with uterine fibroids under the conditions of using hormonal therapy and a drug with anxiolytic effect. Materials and methods. The study analyzed the results of 60 women with uterine fibroids who had anxiety disorder symptoms. The patients were divided into two groups: Group I – patients with uterine fibroids who took combined oral contraceptives (n=30); Group II – patients with uterine fibroids who took the anxiolytic medication fabomotizole concurrently with combined oral contraceptives (n=30). Results and discussion. The research established that patients with uterine fibroids had a change in their psycho-emotional state with a tendency to a high level of anxiety and depression. Treatment with combined oral contraceptives and fabomotizole demonstrated a more stable emotional background as compared to patients who took only combined oral contraceptives. The percentage of patients with the low level anxiety increased and the percentage of patients with the high level anxiety decreased. Among women who were treated with combined oral contraceptives only, there was still a considerable proportion of patients with high levels of anxiety and depression. It was found that the use of combined oral contraceptives in combination does not result in changes regrading the size of the tumor compared to the indicators of patients who did not take the drug with an anxiolytic effect. However, this group of patients demonstrated a tendency to stabilize the growth of nodes, to decrease clinical manifestations in the form of pain and intermenstrual bleeding in the first months of taking combined oral contraceptives. It should be noted that in patients who were not administered fabomotizole, the studied indicators remained at a lower level compared to the indicators of patients who were prescribed this drug. Probably, restoration of the psycho-emotional state in women with uterine fibroids under the influence of fabomotizole increases the effectiveness of hormonal therapy. Conclusion. The patients of both studied groups were shown to have developed pronounced anemia, which was confirmed by low values of hemoglobin in the blood, and the levels of ferritin and transferrin in the blood serum decreased. An increase in the studied indicators was observed after combined oral contraceptive treatment, and specifically after treatment with a combination of combined oral contraceptives and fabomotizole. However, the levels of ferritin and transferrin remained at a lower level compared to normal values
Structure of Anemic Syndrome in Patients with Chronic Forms of Coronary Artery Disease
Authors:   Bukovinian State Medical University, Department of Internal Medicine, Clinical Pharmacology and Occupational Diseases. 2, Theatralna Sq., Chernivtsi 58002, Ukraine, Pavliukovych N. D. , Pavliukovych O. V. , Shuper V. O.
Published: December 2022

The purpose of the study was to determine the incidence and characteristic features of anemia in elderly and senile patients with chronic forms of coronary artery disease. Materials and methods. 1,993 case reports of patients with chronic forms of coronary artery disease with comorbid anemia were analyzed retrospectively. All patients were diagnosed with chronic coronary artery disease (stable angina pectoris of II-III functional classes, diffuse or focal (post-infarction) cardiosclerosis). Average age of investigated patients was 79.5 ± 5.24. Comorbid anemia was diagnosed in case of hemoglobin level below 130 G/l in males and 120 G/l in females. The patients were randomized by gender, age and form of coronary artery disease. Results and discussion. Among all examined patients with coronary artery disease anemia is found in nearly 70% of cases, which coincides with the literature data. In people after 60 anemia is more common in men than in women, while in young and middle-aged patients anemic syndrome is more typical in females. Only in less than hundred case reports the diagnosis of anemia was recorded in the final clinical diagnosis during patients’ discharge from the hospital, in another cases low hemoglobin level was not taken into consideration by physicians. Approximately only one-third of all cases of severe anemia was not diagnosed in a hospital and no appropriate correction of hemoglobin level was performed. Incidence of anemia does not depend on the form of the chronic coronary artery disease (stable angina pectoris or cardiosclerosis). In most patients with coronary artery disease comorbid anemia is of normochromic and normocytic character. Along with progression of the severity of the comorbid anemia, statistically significant increase of the hospitalization period is observed. In patients with coronary artery disease and comorbid anemia the frequency of hospitalizations per year is also increased along with anemia degree of severity progressing. Conclusion. Chronic forms of coronary artery disease in elderly and senile patients in 69.89% of cases are complicated by comorbid anemia of different degrees of severity. In older patients with coronary artery disease, anemic syndrome is most often caused by respiratory diseases, stomach ulcer and duodenal ulcer, cancer of different localization. In most patients with coronary artery disease comorbid anemia is of normochromic and normocytic character. Comorbid anemia in patients with coronary artery disease contributes to the prolongation of the patients’ in-hospital treatment and increasing of the frequency of hospitalizations due to the main disease throughout the year
Dynamics of the Level of Endothelial Monocyte Activating Polypeptide-ІI in Patients with Acute Myocardial Infarction with Concomitant Diabetes Mellitus Type 2
Authors:   Kharkiv National Medical University, Department of Internal Medicine №2, Clinical Immunology and Allergology named after academician L.T. Malaya. 4, Nauky Ave., Kharkiv 61001, Ukraine, Feldman D. A.
Published: December 2022

The purpose of the study was to investigate the dynamics of endothelial monocyte activating polypeptide-ІІ in patients with acute myocardial infarction with concomitant diabetes mellitus type 2 six months after a coronary event. Materials and methods. 120 patients participated in the study: group 1 – patients with acute myocardial infarction with diabetes mellitus type 2 (n=70), group 2 – patients with acute myocardial infarction (n=50). The control group included 20 practically healthy people. All patients underwent laboratory and instrumental examination on the first day of acute myocardial infarction and 6 months after it. The level of endothelial monocyte activating polypeptide-ІІ was determined using the test system “Human Endothelial Monocyte Activating Polypeptide-ІІ ELISA KIT”. Results and discussion. The average level of endothelial monocyte activating polypeptide-ІІ on the first day of an acute myocardial infarction was: in patients who were part of the 1st group – 4.54 ± 0.331 ng/ml; 2nd – 2.74 ± 0.21 ng/ml; control group – 1.1 ± 0.037 ng/ml (р<0.05). In patients of the 1st group, half a year after acute myocardial infarction, the average level of endothelial monocyte activating polypeptide-ІІ was equal to 3.6 ± 0.11 ng/ml; 2nd – 2.28 ± 0.05 ng/ml (р<0.00001). Re-examination of patients, depending on treatment tactics, showed the following results: in patients with acute myocardial infarction with concomitant diabetes mellitus type 2 after cardiac ventriculography, the endothelial monocyte activating polypeptide-ІІ level was equal to 3.5 ± 0.04 ng/ml; in patients with acute myocardial infarction with concomitant diabetes mellitus type 2 after standard anticoagulant therapy it was 3.71 ± 0.03 ng/ml; in patients with isolated acute myocardial infarction after cardiac ventriculography – 2.24 ± 0.01 ng/ml; in patients with isolated acute myocardial infarction after standard anticoagulant therapy – 2.33 ± 0.04 (р<0.01). Conclusion. Endothelial monocyte activating polypeptide-ІІ is a marker of endothelial dysfunction that has prognostic properties in relation to comorbid pathology in the form of acute myocardial infarction with. diabetes mellitus type 2. In patients with an acute myocardial infarction in the presence of diabetes mellitus type 2, a higher level of endothelial monocyte activating polypeptide-ІІ was noted on the 1st day of a coronary event and 6 months after it, compared to patients with an isolated acute myocardial infarction and individuals of the control group (p<0.05). After cardiac ventriculography in patients, the level of endothelial monocyte activating polypeptide-ІІ was significantly lower compared to this indicator after standard anticoagulant therapy
Clinical Characteristics of the Oral Mucosa of Patients with Red Lichen Planus, Depending on the Anatomical Location
Authors:   Ivan Horbachevsky Ternopil National Medical University, Department of Therapeutic Stomatology. 7, Olena Teliga St., Ternopil 46001, Ukraine, Bozhyk S. S.
Published: December 2022

The purpose of the study was to state the clinical characteristics of the oral mucosa in patients with red lichen planus depending on the anatomical localization of the process. Materials and methods. Examinations and a complex of treatment measures were carried out on the basis of the department of Therapeutic Dentistry of the I. Horbachevsky Ternopil National Medical University and the licensed private dental clinic “DVM», Ternopil. 42 patients with red lichen planus were examined. The patients underwent a general clinical dental examination with the registration of indicators in the medical cards of the dental patient, form 043/y, and assessment of the state of oral hygiene according to J. C. Green, J. R. Wermillion, by objectifying the state of periodontal tissues based on index analysis in the modification of C. Parma. Results and discussion. The most typical places of lesions by this nosological unit are the cheeks along the line of teeth closure, the retromolar area. The papules are small silver-grey or white-grey in colour with a characteristic waxy sheen, which is most visible under side lighting conditions. Taking into account the regional features of the structure of the mucous membrane of the back of the tongue, the lesion elements are visualized in the form of plaques that merge into shapes and resemble rings and chains in appearance. When the process spreads to the gums, there is a tendency to an increase in the volume of the interdental gingival papillae and a change in the structure of the gums in the form of maceration and colour of the gums. Features of the clinical picture of the course of this disease on the red border of the lips in the form of a plaque reflect the regional anatomical and morphological features of the red border itself, namely the insignificant thickness of the epithelial plate and the submucosal base. The above-mentioned differences in the clinical picture of red lichen planus should be taken into account at the stage of applying the main clinical methods, as well as the topographic and morphological features of the structure of the mucous membrane at the stage of verification of the lesion elements by a dentist. Conclusion. It is advisable to take into account the visualized differences in the clinical picture of red lichen planus at the stage of application of the main clinical methods as well as the topographical and morphological features of the structure of the mucous membrane at the stage of verification of the lesion elements by a dentist. Thus, in this way, a wide variety of clinical manifestations, complex etiopathogenetic mechanisms of the development of red lichen planus, require a personalized, complex analysis based on an individual approach to each patient, taking into account the aetiology, clinic and regional features of the oral mucosa
The Influence of Occupational Therapy on Indications of the Sensory Profile of Children with Autism Spectrum Disorders
Authors:   National University of on Physical Education and Sport, Department of Рhysical Тherapy and Оccupational Тherapy. 1, Fizkultury St., Kyiv 03150, Ukraine, Vitomska M. V.
Published: December 2022

The purpose of the study is to assess the effectiveness of occupational therapy on the sensory integration indicators of children with autism spectrum disorders in early childhood. Materials and methods. 60 patients (from 3 to 5 years old), who received rehabilitation measures for 6 months, participated in the study. In the control group, children received a standard corrective program. Children of the main group 1 additionally went through occupational therapy sessions, which were addressed to developing self-care skills. In the main group 2, in addition to the main group 1 therapy, children received sensory integration therapy (imitation abilities, orientation in space, coordination, sensory perception, changing the sensory environment). The study used a short sensory profile. Evaluation was carried out by occupational therapists before the start of the intervention and after completion of the program. Results and discussion. Comparison of the three groups according to the initial results of the total sensory profile score did not establish statistical differences between the groups (χ²=2.594; p=0.273). The initial indicators of х̅ ± SD of the total score in the control group were 88.4 ± 4.11 points, in the main group 1 – 91.45 ± 7.12 points, and in the main group 2 – 89.7 ± 7.83 points. Comparison of the three groups according to the final results of the total sensory profile score established statistical differences (F=604.805; p<0.001). х̅ ± SD indicators in the control group were 100.5 ± 4.56 points, in the main group 1 – 158 ± 6.61 points, and in the main group 2 – 165 ± 7.73 points. A conducted posteriori test established the presence of statistical differences between the control group and other groups (p<0.001), between the main group 1 and the main group 2 (p<0.01). It should be noted that the increase in х̅ in the control group was 12.1 points, in the main group 1 – 66.55 points, and in the main group 2 – 75.3 points, which was 13.69%, 72.77% and 83.95% of the initial values, respectively in groups. Conclusion. The addition of occupational therapy sessions to a standard remedial program improved the effectiveness of the intervention on all item scores and the Short Sensory Profile total score. However, adding occupational therapy classes and sensory integration therapy to the standard correctional program had the best effect on sensory integrative indicators. The results obtained by us are a consequence of the fact that in the control group the changes were less shown than in other groups, and in the main group 2 they were the most shown. At the same time, in the main group 1 and main group 2, the comparison of the final and initial results established statistical changes in all points of the sensory profile