bluuebunny/crossref_metadata_2025 huggingface dataset:
Methodology for Designing Analytical Information Systems for Administrative Management
Authors: TROFYMCHUK O. , NESTERENKO O. , NETESIN I.
Published: August 2022

Introduction. In the field of administrative management, the intensity of management activities and the amount of information that needs to be processed for decision-making are constantly growing. In these conditions, the use of new information technologies in the analytical information activities of administrative bodies and the construction of appropriate automated systems is of particular importance.Problem Statement. There is an urgent need for a new approach to solving problems related to the develop ment of analytical information activities and the automation of administrative activities of the authorities. Such an approach should be based on information, consider the modern idea of information as an intellectual product, i.e. knowledge, and as a resource of society, and ensure the complexity of solutions.Purpose. The purpose of this research is to develop a methodology for designing analytical systems based on the integration of concepts, models, methods and information technologies, given the requirements for the comp lexity of solutions.Materials and Methods. The methodology is based on concepts, models, methods, and information technologies, given the requirements for complexity, support for management decisions based on knowledge-oriented tools, their comprehensive information support, support for document processing, information and cybersecurity, as well as the integration of analytical information systems with interoperability.Results. Based on the study, an example of methodology for building a typical information and analytical system of administrative bodies has been proposed. It can be used in the construction of automated systems in various governments, in particular regional government.Conclusions. The theoretical foundation is the regulations for the processing of document flows in the administrative authorities, based on the requirements of the policy of enforcement. The practical significance of the obtained results is the creation of a scientific and methodological framework for building analytical information systems in various areas of administrative management.
Retromolar Canal Diagnosed by Cone-Beam Computed Tomography and its Influence in Inferior Alveolar Nerve Block
Authors: Costa Eliana Dantas , Fortes João Henrique Parise , Cruvinel Pedro Bastos , Gaêta-Araujo Hugo , Mendonça Lucas Moreira , De Freitas Bruna Neves , Pedrazzi Vinícius , Oliveira-Santos Christiano , Tirapelli Camila
Published: August 2022

The aim of this study was to observed the anesthetic efficacy of the alveolar nerve block on nine patients that CBCT diagnosed unilateral retromolar canal on a double-blind, split-mouth approach. The assessments of patient response to thermal (pulp vitality test) and pressure (compression of soft tissue) stimuli were carried out before and 5 minutes after the inferior alveolar nerve block procedure, using both visual analog scale (VAS) and Mc Gill pain questionnaires (McG). The mean percentage of patient response decreased after alveolar nerve block, according to both VAS and McG, and was statistically similar among hemi mandibles with and without retromolar canal (Wilcoxon>0.05); however, those without retromolar canal presented greater reduction in patient response in 6 out of 9 cases. Therefore, the retromolar canal is not a determinant factor of inferior alveolar nerve block failure.
The features of coronavirus disease in pregnant women and the frequency of perinatal complications depending on the severity of the course of this disease
Authors:   Shupyk National Healthcare University of Ukraine, Kyiv, Balan A.V. ,   CNE «Kyiv City Center for Reproductive and Perinatal Medicine», Ukraine
Published: August 2022

Purpose - to analyze clinical and laboratory changes in women with mild to moderate coronavirus disease, the frequency of gestational complications depending on the course of the disease. Materials and methods. 120 pregnant women of the main group with coronavirus disease were involved in the clinical and laboratory examination. The control group consisted of 40 women with gestational age from 22 to 41 weeks, whose pregnancy was not complicated by coronavirus disease. The course of the disease and the impact of coronavirus infection on the course of pregnancy were evaluated by the results of general - clinical, laboratory and instrumental examinations. Results. The surveyed women underwent treatment in the period from 2021 to 2022 at the Communal Non-profit Enterprise «Kyiv City Center for Reproductive and Perinatal Medicine». The mild course of disease had 48 (40%) pregnant women, the course of coronavirus disease of moderate severity had 72 (60%) pregnant women. Symptoms of coronavirus disease observed in pregnant women: hyperthermia - body t≥37.0oC (85 (70.8%) women), general weakness (103 (85.8%) women), loss of smell and taste (27 (22.5%) women), catarhal phenomena (69 (57.5%) women). Decrease in saturation to 92-94% was noted at 18 (15%) pregnant women. The following complications of pregnancy were observed: the threat of premature birth, oligohydramnios, polyhydramnios, fetal growth retardation, structural changes in the placenta according to ultrasound examination of the fetus, violation of fetal-placental blood flow I-II centuries. Conclusions. Given the data of the analysis, it is possible to identify certain features of clinical and laboratory manifestations of coronavirus disease. The most common clinical manifestations are hyperthermia and general weakness. Features of changes in laboratory blood parameters are as follows: leukopenia, lymphocytopenia, increased C-reactive protein and D-dimer, decreased activated partial thromboplastin time, increased prothrombin time, increased total fibrinogen. The most common complications in pregnant women with mild to moderate coronavirus disease: the risk of premature birth, structural changes of the placenta and oligohydramnios. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of all participating institutions. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the author. Keywords: coronavirus disease, pregnant women, extragenital pathology, complications of pregnancy.
Myocardial dysfunction as a component of multiple organ discrepancy with neonatal sepsis
Authors:   Bukovynian State Medical University, Chernivtsi, Ukraine, Kretsu N.М. , Koloskova О.К. ,   Bukovynian State Medical University, Chernivtsi, Ukraine, Shakhova О.О. ,   Bukovynian State Medical University, Chernivtsi, Ukraine
Published: August 2022

The formation of myocardial dysfunction in neonatal sepsis remains a topical issue in current neonatal practice. Myocardial dysfunction with neonatal sepsis is found to promote a double increase of neonatal loss rate, and maintenance of an adequate cardiac output is very important predictor for survival of patients with neonatal sepsis. Purpose - to study clinico-paraclinical markers of myocardial dysfunction in case of an alternative term of neonatal sepsis debut for timely verification and rational correction of cardiovascular disorders. Materials and methods. Considering various terms of neonatal sepsis manifestation with its early and late variants, a comparative analysis of clinical-paraclinical markers of generalized infectious-inflammatory process was made in 26 neonates at the stage of obstetrical aid (retrospective analysis) and in the intensive care departments for neonates and their resuscitation (prospective follow-up). According to the results of the analysis of medical records of newborns, the diagnosis of early neonatal sepsis was established in 14 (53.8%) newborns who were included in the clinical group I of the study, and the diagnosis of late neonatal sepsis was established in 12 (46.2%) newborns who were included in the clinical group II. Results. After birth general condition of patients from the group I was assessed as of moderate severity - in 1 (7.1%) and severe - in 13 (92.9%) neonates; in the group II the 2 neonates (16.7%) were in the condition of moderate severity (р>0.05) and 10 (83.3%) neonates were in severe condition (р>0.05). Assessment of cardiovascular constituent in the neonatal groups of comparison according to the constellation scale nSOFA in the means values did not differ reliably, though it was indicative of a tendency to deeper disorders in case of late neonatal sepsis. Conclusions. Sepsis-induced myocardial dysfunction is manifested by increase in the content of cardio-specific markers (creatine phosphokinase, МВ fraction, troponin I). An increased content of troponin I in the blood higher than that of the norm in case of late neonatal sepsis possesses a high inclination (83.3%) to the formation of myocardial dysfunction. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors. Keywords: neonates, neonatal sepsis, myocardial dysfunction.
Appendicular cancer: relevance, diagnosis, treatment, prognosis. Results of an in-house clinical observation
Authors:   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv, Dronova V.L. , Dronov O.I. ,   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv,   Bogomolets National Medical University, Kyiv, Ukraine,   Kyiv Regional Clinical Hospital No.10, Ukraine, Mokryk O.M. ,   SI Institute of Pediatrics of Obstetrics and Gynecology named after academician O.М. Lukyanova of the NAMS of Ukraine, Kyiv, Bakunets P.P. ,   SI Institute of Pediatrics of Obstetrics and Gynecology named after academician O.М. Lukyanova of the NAMS of Ukraine, Kyiv,   Bogomolets National Medical University, Kyiv, Ukraine,   Kyiv Regional Clinical Hospital No.10, Ukraine, Bakunets Y.P. ,   SI «Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine», Kyiv,   Bogomolets National Medical University, Kyiv, Ukraine,   Kyiv Regional Clinical Hospital No. 10, Ukraine, Tesluk R.S. ,   SI «Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine», Kyiv
Published: August 2022

The article is devoted to cancer of the appendix, which is extremely rare. The incidence of worm cancer is 0.5% of all forms of colon cancer. According to the histological classification there are 7 forms of this malignant pathology: neuroendocrine tumor, mucinous cystadenoma, mucinous cystadenocarcinoma, adenocarcinoma of the colon, goblet cell cancer, ring cell adenocarcinoma, paraganglioma. The article highlights the risk factors for appendicular cancer. Clinical manifestations, diagnostic criteria and treatment tactics of this type of colon neoplasm are described in detail. Data on 5-year survival and prognosis in this type of oncological pathology are given. The results of the patient’s own clinical observation of worm cancer are described in detail. Purpose - in view of the rare occurrence of apendicularis cancer to make a clinical case of its treatment in the department of operative gynecology of SI «Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine» for the formation of alertness of physicians to this pathology. There were outlined risk factors of apendicular cancer development. There were described in detail clinical manifestations, diagnostic criteria and treatment tactics of this type of colon cancer. There were given the data of 5-year survival rate and prognosis of this kind of oncologic pathology. Separately, there were described in detail the results of the in-house clinical monitoring of cancer of the worm gastrointestinal tract in a female patient. The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors. Keywords: cancer of the appendicular process, 5-year survival, prognosis, risk factors.
Hoax News and Technology Literacy from the Qur’anic Perspective
Authors: Yusuf Muhammad Yusuf
Published: August 2022

The development of media technology and freedom of releasing news led to fake news or hoaxes spread to form a public opinion in order to get particular interests which are used to attack each other, accuse, slander, and generate stereotypes, even to claim that a specific group or religion is superior to others. This study takes under scrutiny the Qur'anic perspective about hoaxes and technology literacy to help provide context for an effort to combat fake news. Using a thematic and an anthropological approach to the Qur’an, this study has found that the Qur’an narrates that hoaxes have existed since the first humans, Adam and Eve, to test the true faith as well as pretense. The Qur’an gives a sign that the eternal enemy of honesty is a hoax. Tabayyun is a crucial concept for fighting hoaxes, and qalam is the medium.
PÚBLICO-PRIVADO NO FINANCIAMENTO DA EDUCAÇÃO ESPECIAL: QUEM GANHA E QUEM PERDE NO MERCADO DA BENEMERÊNCIA?
Authors: Nunes Lorrana Oliveira , Rodrigues Ana Cláudia da Silva
Published: August 2022

Este artigo objetiva analisar o jogo de disputas e negociações pelo fundo público entre as parcerias público-privadas no financiamento da educação especial. As discussões derivam da revisão bibliográfica e documental de escritos alinhados ao objetivo eleito, e estão sustentadas nos pressupostos teóricos do materialismo histórico-dialético (MARX, 1985). Na análise das fontes consultadas, verificou-se que no contexto de desoneração do Estado em relação às políticas sociais, as parcerias público-privadas ganham a disputa no mercado da benemerência em detrimento ao público-alvo da educação especial, e buscam os recursos do fundo público e a participação nos direcionamentos das políticas educacionais. Evidenciou-se ainda, que a parceria entre o Estado e o setor privado contribuiu para precarizar o ensino público, alimentar tensões entre os direitos conquistados e os direitos efetivados, e para descumprir as metas do PNE 2014-2024 e dos pactos firmados entre o Brasil e os organismos internacionais, como a Declaração de Salamanca (1994). Por outro lado, os achados revelaram algumas saídas para combater o apartheid social e educacional, que tem sido disseminado pela classe empresária na saga da disputa pelo fundo público: desenvolver a capacidade de organização, de acesso à informação e de comunicação interna para garantir os investimentos públicos; superar a gestão centralizada nos espaços escolares; e fortalecer o controle social por meio da participação social e popular.
DESIGNING OF DIFFERENT TYPES OF GYROID SCAFFOLD ARCHITECTURE TO ACHIEVE PATIENT-SPECIFIC OSSEOINTEGRATION FRIENDLY MECHANICAL ENVIRONMENT
Authors: Gupta Abhisek , Rana Masud , Mondal Nitesh , Das Apurba , Karmakar Amit , Chowdhury Amit Roy
Published: August 2022

Porous three-dimensional scaffolds provide a favorable environment for the regeneration of tissues and organs to recover the injured tissue in terms of structure and biological function. Proper design of scaffold architecture is a crucial factor for tissue engineering. The mechanical properties and performance of the scaffold depend on the scaffold architecture, material, and geometry. In this study, numerical analysis is performed on four types of gyroids to see the variation of effective elastic modules in three different directions. The fluid flow induces wall shear stress (WSS), considering the Newtonian fluid is also investigated. Initially, the WSS is evaluated through computational fluid dynamics simulation and compared to previous literature. A good agreement between the results of published literature and those initial works encourages dealing with several cases by varying different parameters. The effect of scaffold architecture, pore size, and flow direction on WSS is studied using 16 different gyroid models. A significant reduction of scaffold stiffness can be achieved with porosity, and WSS increases with a decrease in pore size. Inlet flow direction also has a good influence on WSS. Fluid flow perpendicular to the gyroid cross-sectional area gives maximum WSS and gradually decreases with an increase in direction angle. The present study can be used to reference a specific scaffold design in tissue engineering.
A Novel Mouse Model of Idiopathic Nephrotic Syndrome Induced by Immunization with the Podocyte Protein Crb2
Authors: Hada Ichiro , Shimizu Akira , Takematsu Hiromu , Nishibori Yukino , Kimura Toru , Fukutomi Toshiyuki , Kudo Akihiko , Ito-Nitta Noriko , Kiuchi Zentaro , Patrakka Jaakko , Mikami Naoaki , Leclerc Simon , Akimoto Yoshihiro , Hirayama Yoshiaki , Mori Satoka , Takano Tomoko , Yan Kunimasa
Published: August 2022

Significance Statement

The cause of podocyte injury in idiopathic nephrotic syndrome (INS) remains unknown. Although clinical evidence points to an autoimmune origin, currently available animal models are not mediated by autoimmunity, limiting further research on the mechanisms leading to INS. We developed a mouse model mimicking human INS, induced by immunization with the podocyte foot process protein Crb2. Mice developed anti-Crb2 autoantibodies and heavy proteinuria, mimicking pathological features of minimal change disease or FSGS in humans. The results indicate that autoantibodies against podocyte proteins can injure the cells, causing nephrotic syndrome in mice. Crb2 immunization could be a useful model to study the full immune pathogenesis of human INS.

Background

The cause of podocyte injury in idiopathic nephrotic syndrome (INS) remains unknown. Although recent evidence points to the role of B cells and autoimmunity, the lack of animal models mediated by autoimmunity limits further research. We aimed to establish a mouse model mimicking human INS by immunizing mice with Crb2, a transmembrane protein expressed at the podocyte foot process.

Methods

C3H/HeN mice were immunized with the recombinant extracellular domain of mouse Crb2. Serum anti-Crb2 antibody, urine protein-to-creatinine ratio, and kidney histology were studied. For signaling studies, a Crb2-expressing mouse podocyte line was incubated with anti-Crb2 antibody.

Results

Serum anti-Crb2 autoantibodies and significant proteinuria were detected 4 weeks after the first immunization. The proteinuria reached nephrotic range at 9–13 weeks and persisted up to 29 weeks. Initial kidney histology resembled minimal change disease in humans, and immunofluorescence staining showed delicate punctate IgG staining in the glomerulus, which colocalized with Crb2 at the podocyte foot process. A subset of mice developed features resembling FSGS after 18 weeks. In glomeruli of immunized mice and in Crb2-expressing podocytes incubated with anti-Crb2 antibody, phosphorylation of ezrin, which connects Crb2 to the cytoskeleton, increased, accompanied by altered Crb2 localization and actin distribution.

Conclusion

The results highlight the causative role of anti-Crb2 autoantibody in podocyte injury in mice. Crb2 immunization could be a useful model to study the immunologic pathogenesis of human INS, and may support the role of autoimmunity against podocyte proteins in INS.
Impact of the flipped classroom approach in engineering education: A course analysis
Authors: K Arulkumar , M Vaigundamoorthy , Prabaharan Natarajan , Subramaniam Umashankar
Published: August 2022

Abstract: The main purpose of the paper is to present a course analysis on the use of the flipped classroom. The objective is to explore the advantages and challenges for students and instructors. The impact of flipped classroom learning is analyzed with a set of students in the classroom. Student perceptions of lecture based learning and flipped classroom is compared to explore and promote active learning methodologies. The challenges of implementing a flipped classroom were identified and addressed using a variety of student-related activities. Mobile app learning methods, scale-up classroom and effective laboratory courses were implemented for a set of students. The significance of the flipped classroom model is noted. It was found that it promotes a deeper, broader perspective on learning, improves critical thinking capabilities and team work skills needed for a successful engineering career. Keywords: flipped classroom, scale-up classroom, active learning, learning outcomes
Fuzzy AHP-TOPSIS approaches to prioritize teaching solutions for Intellect Errors
Authors:   Chitkara University Institute of Engineering and Technology, Chitkara University, Punjab, India., Kukreja Vinay
Published: August 2022

Abstract: The teaching fraternity and intellects play an important role in students’ careers as they make students industry-ready. During their teaching, they make different types of errors. One of the neglected aspects during teaching is intellect errors and these directly or indirectly impact students learning capabilities. The scattered literature shows that there are twelve types of intellect errors like ‘error of coincidence’, ‘senses error’, ‘analogy error’, ‘subjectivity error’, etc. To minimize these errors, six solutions have been identified like ‘selection of right instruments’, ‘developmeand least rated intellect errors respectively. Thent of critical thinking in the students’, ‘aware about knowledge engineering development’ etc. This study aims to identify and prioritize the solutions to overcome the errors of the intellect that has been the ignored aspect of the teaching till now. A hybrid approach of fuzzy AHP (Analytical Hierarchy Process) and Fuzzy TOPSIS (Technique for Order of Preference by Similarity to Ideal Solution) has been proposed to rank the solutions that minimize the intellect errors. Fuzzy AHP is used to compute the weights for intellect errors by doing the pairwise comparison and fuzzy TOPSIS is used to rank the identified solutions with the help of generated weights of fuzzy AHP. The results show that “error of proximity” and “senses error” are the highest topmost rated solution to handle errors of the intellect is “development of critical thinking in the students”. Keywords: Intellect errors, fuzzy AHP, fuzzy TOPSIS, industry-ready
Design and Validation of the Academic Research Aptitude Scale
Authors: Mathew Jain , Elangovan N , Sheeba Sridevi Nair , . Bhaskar , Yadav Preksha
Published: August 2022

Abstract :Universities across the world have now started focusing on creating and nurturing academic researchers. While the importance and benefits of a strong research mindset have been understood, the process of identifying and developing researchers lacks a sense of structure. The current study attempts at filling this gap by proposing and testing the Academic Research Aptitude Scale. The scale was created and tested using the DeVellis (2016) method. The initial pool of items consisted of 29 items that were generated in the course of a brainstorming session. The discussion with experts and literature review resulted in a 22-item instrument which was then reduced to 21 items, post the item analysis. The analysis was carried out on a sample of 303 research scholars and researchers. The exploratory factor analysis helped in the identification of the dimensions and the same was then checked using confirmatory factor analysis. The scale fulfilled the validity requirements and showed high reliability, as shown by Cronbach's alpha score. The final scale consists of 21 items. Keywords: researchers; research scholars; academics; India
Redesign of Digital Circuits course for enhanced learning
Authors:   School of ECE, KLE Technological University, Hubballi, India, Budihal Suneeta , Salunke Minal ,   Department of ENE, KLE Technological University, Hubballi, India, Kinnal Bhagyashree ,   School of ECE, KLE Technological University, Hubballi, India, Iyer Nalini ,   School of ECE, KLE Technological University, Hubballi, India
Published: August 2022

Abstract: The paper presents the restructuring of course design and delivery, to attain the enhanced learning in Digital Circuits course through pedagogic practices and hands on experience in laboratory. The objective of the paper is to enhance the understanding of the course beyond the class room teaching. The traditional approach of course design, course delivery and course assessment provide less scope for better learning of courses. To address the limitations of traditional approaches, an Outcome Based Education (OBE) proposes many pedagogical practices. The paper proposes a framework to restructure the Digital Circuits course w.r.t.. to content delivery in the class, course projects and the reframing the laboratory experiments. The contents delivery is supported by expert lecture through videos, course project is aided by concept/prototype development and the lab is formulated to exercise multiple problems on a single topic. The students' attainment is measured and analyzed through examination results and feedback. The technical and professional outcomes are achieved through the proposed framework. Keywords: Digital Circuits, alternate design, OBE, course design, course project, simulation.
Defining Vocational Teacher Competencies in Industry 4.0 from the Perspective of Teachers and Lecturers
Authors:   Departemen Pendidikan Kesejahteraan Keluarga, Universitas Pendidikan Indonesia, Jl. Dr. Setiabudhi No. 229 Bandung,  Indonesia, Ana A. , Kustiawan Iwan ,   Departemen Pendidikan Teknik Elektro, Universitas Pendidikan Indonesia, Jl. Dr. Setiabudhi No. 229 Bandung, Indonesia, Ahman Eeng ,   Prodi Pendidikan Ekonomi, Universitas Pendidikan Indonesia, Jl. Dr. Setiabudhi No. 229 Bandung, Indonesia, Zakaria S. ,   Departemen Pendidikan Seni Rupa, Universitas Pendidikan Indonesia, Jl. Dr. Setiabudhi No. 229 Bandung, Indonesia, Muktiarni M. ,   Departemen Pendidikan Kesejahteraan Keluarga, Universitas Pendidikan Indonesia, Jl. Dr. Setiabudhi No. 229 Bandung,  Indonesia, Dwiyanti Vina ,   Prodi Pendidikan Teknik Logistik, Universitas Pendidikan Indonesia, Jl. Dr. Setiabudhi No. 229 Bandung, Indonesia, . Saripudin ,   Politeknik TEDC, Jl. Pesantren No.KM.2, Cibabat, Kec. Cimahi Utara, Kota Cimahi, Indonesia7Prodi Pendidikan, Khoerunnisa Indah ,   Teknologi Agroindustri, Universitas Pendidikan Indonesia, Jl. Dr. Setiabudhi No. 229 Bandung, Indonesia
Published: August 2022

Abstract: The purpose of this study was to analyze the competence of vocational teachers needed in implementing the independent learning policy based on the opinions of teachers and lecturers. The research method uses quantitative methods on 356 teachers and lecturers. The results showed the priority of vocational teacher competency indicators from pedagogical competence, social competence, personality competence, and professional competence. The pedagogic competency indicator that is needed by vocational teachers is the ability to motivate students. An indicator of social competence that is needed by vocational teachers is having a polite and polite attitude. Personality competency indicators that are needed by vocational teachers are having an honest personality, and indicators of professional competence that are needed by vocational teachers are the ability to transfer knowledge and technology. Keywords: competence, competence of teachers, vocational teachers, independent learning, teachers, lecturers
A Hybrid Facilitation Model For Inexperienced Students Via Integration of Teacher-Centred and Student-Centred Roles
Authors:   Faculty of Technical and Vocational Education, Universiti Tun Hussein Onn Malaysia, Malaysia, Masek Alias , Salleh Kahirol Mohd ,   Faculty of Technical and Vocational Education, Universiti Tun Hussein Onn Malaysia, Malaysia, Alias Maizam ,   Faculty of Technical and Vocational Education, Universiti Tun Hussein Onn Malaysia, Malaysia
Published: August 2022

Abstract: Inadequate experience in handling Student- Centred Learning (SCL) approaches may hinder teachers from demonstrating the full spectrum of the facilitation as proposed in the Heron facilitation model. Therefore, this study was undertaken to investigate the utility of the Heron facilitation model in SCL among teachers and students of higher educational institutions who are relatively inexperienced in SCL. The participants were 177 teachers from a higher engineering educational institution, and a survey using questionnaires was carried out to gauge their experience with the SCL facilitation methods. The results obtained by using the Exploratory Factor Analysis (EFA) indicate the presence of four new dimensions instead of six, as proposed in the Heron model, namely planning, shared decision-making, flexible teamwork, and shared outcome. The first construct indicates teacher-empowered teaching, while the other three indicate students’ empowered learning. The finding provides a set of new guidelines for novice teachers in planning the facilitation of SCL. Keywords: dimension of facilitation, facilitator, heron facilitation model, higher education, mode of facilitation, student-centred learning
Students’ Participation and Motivational Factors in Student-Centered Learning: A Case of Two Malaysian Vocational Institutes
Authors:   Institut Kemahiran MARA Johor Bahru, Aziz Azlihan Abd , Masek Alias ,   Faculty of Technical and Vocational Education, Universiti Tun Hussein Onn Malaysia, Mohamad Norsuhaidah ,   Faculty of Technical and Vocational Education, Universiti Tun Hussein Onn Malaysia
Published: August 2022

Abstract: The development of a country closely relates to how its national education system is enhanced to address current challenges. Despite an increasing interest in improving the quality of academic-oriented education in Malaysia, research on enhancing the learning quality of Technical and Vocational Education (TVET) remains lacking. Surveying the involvement of TVET students in Student-Centered Learning (SCL), this quantitative study identifies the level of students’ learning motivation and some contributing factors to their involvement in SCL activities. The methodology of the study was a quantitative survey design using questionnaires. Respondents were students of Diploma in Electrical Engineering Technology at Institut Kemahiran MARA (IKM) and Kolej Kemahiran Tinggi MARA (KKTM). A total of 296 responses were received and data analysis was performed using descriptive analysis and inferential statistics. In this study, students participated and were highly motivated while working and learning in an SCL environment. There is a strong positive relationship between students’ participation or involvement factors and students’ motivation. It can be concluded that the implementation of SCL among TVET students requires support from parents and classmates. Therefore, the study provides some recommendations on how to improve the quality of TVET graduates by strengthening these involvement and motivational factors. Keywords: learning participation, learning motivation, SCL, Student-centered learning, TVET
Sexual and reproductive health during Covid: a global systematic review of health system responses and service delivery adaptations v2
Authors: not provided hlconyers
Published: August 2022

The COVID-19 pandemic is on-going and continues to challenge the delivery of SRH services across the globe. The impact has created imbalances in healthcare provision, disruptions of routine essential services and, in most settings, require redeployment of scarce healthcare personnel across SRH services. Additionally, health system disruptions such as supply chain and procurement challenges, distribution and lockdown restrictions have previously and continue to affect SRH service provision. The reduction in the access, use, quality of health services significantly and disproportionately affect populations in humanitarian settings, which makes MISP preparedness and comprehensive implementation even more challenging, specifically so a result of the COVID-19 pandemic. Adaptive and innovative solutions allow for healthcare systems and providers to continue to effectively deliver SRH services, maintaining a high standard of care.
Adult mouse pancreas cell dissociation (on ice) v2
Authors: Potter Andrew
Published: August 2022

Note: In testing several different enzymes to dissociate pancreas tissue on ice, Collagenase Type 4 appeared to be most effective. However, the results of the dissociation have been variable, with significant debris in some preps, and cell type representation has not validated using 10X or flow; further optimization may be needed with this protocol. This procedure is used to dissociate adult (10 wk.) mouse pancreas into single cells. The procedure is carried out on ice in order to maintain a more authentic gene expression profile. It is a two-layered dissociation, with each layer consisting of 5 mg/mL type 4 collagenase. The yield is 4400 cells/mg with 94% viability.
Automated procedure for estimation of methylation levels in MS-HRM analysis v1
Authors: Samsø Mathiasen Sally
Published: August 2022

Testing for disease-related DNA methylation changes provides clinically relevant information in personalized patient care. Methylation-Sensitive High-Resolution Melting (MS-HRM) is a method used for measuring methylation changes and has already been used in diagnostic settings. This method utilizes one set of primers that initiate the amplification of both methylated and non-methylated templates. Therefore, the quantification of the methylation levels using MS-HRM is hampered by the PCR bias phenomenon. Some approaches have been proposed to calculate the methylation level of samples using the high-resolution melting (HRM) curves. However, limitations of the methylation calculation using MS-HRM have not been evaluated systematically and comprehensively. We used the Area Under the Curve (AUC), a derivative of the HRM curves, and least square approximation (LSA) to establish a procedure that allowed us to infer methylation levels in an MS-HRM experiment and assess the limitations of that procedure for the assays’ specific methylation level measurement. The developed procedure allowed, with certain limitations, estimation of the methylation levels using HRM curves.
Our Radiotherapy Results in Patients with Primary Non-Small Cell Lung Cancer with Brain Metastases
Authors: KARACA Feryal , MENTEŞ Selahattin , ARSLAN Ali , SARAÇ Mustafa Emre , KESKİN Sıddık , ÇİL Timuçin
Published: August 2022

Objective: Lung cancer is the most common cancer worldwide and is among the leading causes of cancer death. The aim of this study is to examine the survival of patients who received radiotherapy for the brain metastases, whose primary is non-small cell lung cancer, and also determine the factors that are like to affect the survival and to examine the results of radiotherapy in these patients as well.
Materials and Methods: This study included 99 patients with primary non-small cell lung cancer. All patients with brain metastases received radiotherapy. The patients were grouped and compared according to the number of brain metastases, whether surgery was performed for brain metastasis, gender, pathology and stage of the primary focus, visceral organ involvement, and ECOG performance status after brain metastasis developed.
Results: The change in survival rate according to the number of brain metastases at the time of diagnosis was found statistically significant (p<0.01). When the stages and survival of the patients at the time of diagnosis were compared, it was statistically significant (p<0.01). Similarly, the differences among the ECOG/PS status was also statistically significant (p<0.01). When patients with visceral organ metastases were divided into two groups as to groups as dead and alive, it was observed that the number of exitus that most of the patients were lost to their metastatic state (p<0.001).
Conclusion: Age, gender, the number of brain metastases the number of brain metastases brain metastasis, surgery, ECOG/PS, chemotherapy, radiotherapy and visceral organ metastasis were found to be factors affecting survival in patients with brain metastases.
sujeto no es (sin) el cuerpo: reflexiones en torno a los tratamientos “On-line”
Authors: García Valenzuela Fabian Yesid
Published: August 2022

A partir del interrogante por el estatuto del cuerpo en las relaciones virtuales, se abre el debate sobre la pertinencia, necesidad y eficacia del psicoanálisis a distancia (o psicoanálisis online, o teleanálisis). Se abordan los argumentos que deslegitiman dicha práctica, entre los que se encuentran: la rigurosidad del setting y algunas lecturas “materialistas” de la enseñanza de Lacan. Se hace un repaso por el uso del cuerpo del analista desde la perspectiva de Winnicott, poniéndolo en tensión frente a la propuesta de Lacan, en la que se invita al analista a ocupar la posición del semblante, propuesta en la que se define al sujeto como sustancia gozante y cuya materialidad es significante. En conclusión, entendiendo la voz y la mirada como dos formas del cuerpo, es posible pensar que están dadas las condiciones para llevar adelante el trabajo analítico, siendo el encuentro virtual una herramienta que posibilitará el psicoanálisis en escenarios que antaño eran impensables.
Genç Voleybolcularda Elastik Bantla Yapılan Bench Press ve Squat Egzersizlerinin Kuvvet ve Sıçrama Performansına Etkisi
Authors: SUSAM Kaan , HARBİLİ Erbil , HARBİLİ Sultan
Published: August 2022

Bu çalışmanın amacı, genç erkek voleybolcularda elastik bantla yapılan bench press ve squat egzersizlerinin kuvvet ve dikey sıçrama performansına etkilerini araştırmaktır. Araştırmada 24 sporcu rastgele geleneksel antrenman grubu (GKG, 16.75±1.28 yıl, n=12) ve elastik bant antrenman grubu (EBG, 17.83±1.46 yıl, n=12) olarak ikiye ayrıldı. Voleybolculara sekiz hafta süreyle haftada 2 gün 48 saat arayla sadece bench press ve squat egzersizlerinin elastik bantla yapıldığı yedi kuvvet hareketi içeren antrenman programı uygulandı. Çalışmada squat sıçrama (SS), aktif sıçrama (AS), smaç sıçrama (SMS) yükseklikleri, bench press ve squat hareketlerinin bir tekrar maksimal kuvveti (1 TM), sağlık topu fırlatma mesafesi (STF) ve vücut kompozisyonu ölçüldü. Vücut kütlesi ve vücut kütle indeksi GG’nda EBG’dan daha yüksekti (p<0.05). GG ve EBG karşılaştırıldığında, bench press ve squat 1 TM kuvveti ve sağlık topu fırlatma değerleri arasında anlamlı fark bulunmadı (p>0.05). SS yüksekliği elastik bant antrenman grubunda geleneksel kuvvet antrenman grubundan daha yüksekti (p<0.05), ancak AS ve SMS yüksekliğinde her iki antrenman yönteminin etkisi benzerdi (p>0.05). Sonuç olarak, geleneksel kuvvet antrenmanının vücut kütlesi, yağsız vücut kütlesi ve vücut kütle indeksinde elastik bant antrenmanından daha etkili bir yöntem olduğu görüldü. Bench press ve squat 1 TM kuvveti, sağlık topu fırlatma, AS ve SMS performansında antrenman yöntemlerinin etkilerinin benzer olduğu, elastik bantla kuvvet antrenmanının SS performansında geleneksel kuvvet antrenmanına göre daha etkili olduğu görüldü.
Tecnologia educacional digital sobre HIV/AIDS para adolescentes e jovens: protocolo de revisão de escopo
Authors: Piran Camila Moraes Garollo , Fonseca Beatriz Souza da , Dias Jhenicy Rubira , Shibukawa Bianca Machado Cruz , Rissi Gabrieli , Higarashi Ieda Harumi , Merino Maria de Fátima Garcia Lopes , Furtado Marcela Demitto
Published: August 2022

Objetivo: mapear as evidências científicas acerca do uso de tecnologia educacional digital em saúde relacionada ao HIV/AIDS, direcionada a adolescentes e jovens adultos. Método: trata-se de um protocolo de revisão de escopo, estruturado conforme diretrizes metodológicas do Instituto Joanna Briggs (JBI). Serão utilizadas seis bases de informação, com emprego dos descritores de saúde. O processo de busca, identificação e avaliação de artigos será realizado por dois avaliadores independentes, norteado pelos pressupostos estabelecidos pelo JBI, buscando responder à seguinte questão norteadora: “Quais as evidências científicas encontradas acerca do uso de tecnologia educacional digital em saúde relacionada ao HIV/AIDS, direcionada a adolescentes e jovens adultos?” Serão incluídos artigos publicados no idioma inglês, português ou espanhol, de domínio público e privado, e com diferentes abordagens metodológicas. Os resultados serão apresentados conforme as orientações do Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. O protocolo foi registrado na Open Science Framework (OSF), sob registro nº 10.17605/OSF.IO/QK2G7.
Reading Literary Texts as a Technique to Build Critical Thinking Skills in Linguistics Majors
Authors:   Taras Shevchenko National University of Kyiv, Nesterenko Nataliia , Drahinda Olha ,   Taras Shevchenko National University of Kyiv
Published: August 2022

Background: Radical changes of the present day life challenge the higher educational community to help the student develop into a personality ready to actively and creatively perceive information, to optimally apply the necessary type of mental activity, to analyze information, to have independent opinion and to defend it, to apply the acquired knowledge. This research investigates the efficiency of reading literary texts critically with the purpose of building critical thinking skills of students. Purpose: The article aims at defining ‘critical thinking, specifying the distinctive features of literary texts the criteria applied to select the texts to be an effective tool in building critical thinking skills and suggest a sample set of assignments to help students improve their critical thinking skills. Methodology relies on the critical analysis of the available research on the topic as well as of the authors’ experience in using literary texts to teach critical thinking. Results and discussion: Reading literary text has proved to build students’ critical thinking skills, help develop both personally and professionally. The authors of the article offer a practical set of assignments to build students’ critical thinking skills through reading literary texts. These tasks are based on the critical thinking model by Lindsay Clandfield and correspond to the traditional stages resorted to when working with the text (Before reading, While reading and After reading). Each of the defined stages focuses on utilising some of the six levels of Bloom’s taxonomy of cognitive learning objectives through activities that promote these cognitive processes.In further research, it is necessary to experimentally verify the effectiveness of the critical reading of the literary texts to build critical skills with university language students.
Toxicity profile of the new compound XC221GI from pre-clinical studies
Authors: Suhanova Svetlana A. , Proskurina Oksana V. , Jain Ekaterina A. , Globenko Aleksander A. , Bagaeva Madina I. , Rydlovskaya Anastasia V. , Nebolsin Vladimir E.
Published: August 2022

The major feature of COVID-19 is intensive virus-induced inflammation in vital body organs and spatiotemporal dysregulation of pro- and anti-inflammatory cytokines and chemokines synthesis. All this leads to unpredicted clinical progression and high risk of "cytokine storm" development. The "cytokine storm" is the pathogenetic basis for further development of life-threatening complications. Thus, there is a huge need to select effective and safe approaches that allow to control virus-induced inflammation as a part of preventive anti-inflammatory therapy.
This article presents toxicological characteristics of the original low-molecular compound XC221GI (1-[2-(1-methylimidazole-4-yl)-ethyl]perhydroazin-2,6-dione) from pre-clinical studies.
The obtained results demonstrate that the XC221GI does not have any toxic effect in repeated long-term administration. The compound was well tolerated by all animals. The no-observed-adverse-effect level (NOAEL) was 30 mg/kg per day for dogs and 450 mg/kg per day for rats. There were no effects of XC221GI on blood count, hematopoiesis and hemostasis. As well as no cytotoxic, mutagenic, genotoxic, carcinogenic properties or anaphylactogenic and immunotoxic activity were revealed for XC221GI. All known data enable to classify XC221GI as a low toxic compound and consider its safety profile as reasonably favorable.
sílaba na Libras
Authors: Silva Ione Barbosa de Oliveira , Pacheco Vera , Lessa-de-Oliveira Adriana Stella Cardoso
Published: August 2022

O presente trabalho objetiva investigar a estrutura silábica da libras, a partir de pressupostos estabelecidos sobre as línguas orais e sobre as línguas de sinais, especialmente sobre a American Sign Language (ASL). Para tanto, na tentativa de apontar aspectos relevantes que corroboraram a compreensão da sílaba em libras, retoma-se importantes trabalhos sobre a sílaba nessa língua, como o de Cunha (2011) e o de Aguiar (2013). Neste trabalho, todavia, a base metodológica para tal análise segue o modelo fonológico MLMov (Mão-Locação-Movimento), proposto por Lessa-de-Oliveira (2012; 2019), que estabelece que a estrutura articulatória dos sinais da libras é constituída em quatro níveis hierárquicos. Objetiva-se ainda identificar o núcleo da unidade silábica da libras e descrever se há ou não funcionalidade no Princípio da Sonoridade para identificação desse núcleo. Verifica-se que um critério funcional que dê conta de identificar o núcleo silábico não seria a sonoridade, mas a obrigatoriedade. Como resultados, aponta-se que uma sílaba em libras se constitui de uma unidade MLMov, que poderá ter as seguintes combinações em sua estrutura interna: [MLMov], [ML], [MMov] ou [M]. Dessa forma, compreende-se, por fim, que o segmento presente em todas as unidades MLMov componentes de sinais é Mão, sendo esse, portanto, o núcleo silábico nessa língua.
Frecuencia de mordida abierta en niños de 6 a 12 años en escuelas públicas de Gran Asunción en el año 2019
Authors: Romero-Guirland Adelaida , Invernizzi-Mendoza Carlos Rafael , Valdez-Godoy Lourdes , Benítez Gabriela , Martínez Gricelda , Benítez-Torres Petrona , Sánchez Araceli
Published: August 2022

La mordida abierta se define como aquella situación de la oclusión en la que uno o más dientes superiores o inferiores, no alcanzan el plano de la oclusión por no hacer contacto con los antagonistas. El objetivo fue determinar la frecuencia de mordida abierta en niños entre 6 a 12 años de escuelas públicas de Gran Asunción. Estudio descriptivo observacional, de corte transversal que abarcó 1095 niños de ambos sexos, de 6 a 12 años, de escuelas públicas de Gran Asunción- Paraguay en el 2019 que cumplían con los criterios de inclusión. Se realizaron evaluaciones odontológicas para determinar por medio de observación la presencia de mordida abierta y los datos fueron asentados en planillas Excel para su posterior análisis. Del total de 1095 alumnos, 242 presentan mordida abierta (22,1%). El 57,8% presentó mordida abierta anterior, el 35,5% presenta mordida abierta posterior y un 6.6% mordida abierta completa. Los datos que aporta esta investigación contribuyen para implementar y promover tratamientos a edades tempranas, lo que es de vital importancia por las múltiples consecuencias negativas de este tipo de maloclusiones en el niño, debido a que no sólo afecta a la boca, sino también a la funcionalidad de todo el sistema en el cuerpo humano.
Feedback on-line na formação inicial de professores de línguas: estado da arte
Authors: Zocaratto Bruna Lourenção , Quevedo-Camargo Gladys
Published: August 2022

Este artigo tem como objetivo investigar os efeitos da prática de feedback on-line na formação inicial de professores de línguas, sob a ótica dos licenciandos, tanto no Brasil quanto no exterior. Para isso, baseamo-nos em uma pesquisa de estado da arte, cuja temporalidade foi o período de 2001 a 2021. Os dados revelaram a necessidade de equilíbrio entre feedback geral e personalizado, seu uso com finalidade formativa, além da importância de vivenciá-lo durante seu processo de formação e estudá-lo de modo aprofundado, a fim de conseguirem oferecê-lo com mais consistência e plausibilidade.