bluuebunny/crossref_metadata_2025 huggingface dataset:
El proceso de securitización en la Triple Frontera del Paraná
Authors: Garcia Hernan Ezequiel
Published: November 2023

Este artículo tiene como objetivo reconstruir las transformaciones del proceso de securitización en la región de la Triple Frontera del Paraná desde fines de la década de 1970 hasta 2023. A partir de los estudios críticos de la seguridad y con el uso de la categoría de securitización se lleva a cabo un recorrido histórico para mostrar la construcción de la política argentina de seguridad fronteriza desde el retorno de la democracia hasta la práctica securitaria del cierre de fronteras debido a la pandemia. Mediante la adopción de una perspectiva etnográfica se incorporan hallazgos de tres estancias de trabajo de campo, el análisis documental de la normativa fronteriza argentina y regional, y el rastreo de noticias de medios de comunicación para mostrar que el proceso de securitización de las fronteras se ha ido transformando y reconfigurando según el momento histórico debido a que el miedo por las amenazas cambia a lo largo de las décadas.
SARS-CoV-2 Main Protease Inhibitors from Natural Product Repository as Therapeutic Candidates for the Treatment of Coronaviridae Infections
Authors: Khanfar Mohammad Abdalmoety , Saleh Mohammad Issa
Published: November 2023

Background:

The main protease (Mpro) is a crucial enzyme for the life cycle of
SARS-CoV-2 and a validated target for the treatment of COVID-19 infection. Natural
products have been a proper alternative for treating viral diseases by modulating different
steps of the life cycle of many viruses.

Objective:

This review article is designed to summarize the cumulative information of
natural-derived Mpro inhibitors that are validated by experimental biological testing.

Methods:

The natural-derived Mpro inhibitors of SARS-CoV-2 that have been discovered
since the emergence of the COVID-19 pandemic are reviewed in this article. Only natural
products with experimental validation are reported in this article. Collected compounds
are classified according to their chemical identity into flavonoids, phenolic acids, quinones,
alkaloids, chromones, stilbenes, tannins, lignans, terpenes, and other polyphenolic
and miscellaneous natural-derived Mpro inhibitors.

Conclusion:

These compounds could serve as scaffolds for further lead-structure optimization
for desirable potency, a larger margin of safety, and better oral activity.
Various Synthetic Methods and Diverse Therapeutic Potential of Substituted
Thiazine Derivatives
Authors: Asif Mohammad , Allahyani Mamdouh , Alsaiari Ahad Amer , Almehmadi Mazen Mohammed
Published: November 2023

Heterocyclic compounds are currently of great interest in pharmaceutical research.
Many natural products, including vitamins, hormones, and antibiotics, contain heterocyclic
compounds, and these substances have grown in importance. Heterocyclic thiazine derivatives
have numerous pharmacological actions, including anticancer, antimicrobial, antipsychotic,
anti-mycobacterial, anti-fungal, antiviral, antimycobacterial, antioxidant, analgesic,
antipyretic, anti-inflammatory activities, which is present in numerous substances. The N-CS
linkage in its scaffold and the ease and economy of its synthesis methods have been key
factors in the development of these molecules. Recently, numerous studies considering the
various biological actions of thiazines have been published. Thiazine, a six-membered heterocyclic
compound with nitrogen and sulfur in its ring system, has a wide range of chemical
possibilities, which has encouraged insistent research into their various synthesis processes. The current review
focuses on thiazine derivatives with potential biological activities.
A Comprehensive Review on Nanoparticles as a Targeted Delivery System for the
Treatment of Lung Cancer
Authors: Gupta Twinkle , Varanwal Avinash , Nema Priyanshu , Soni Sakshi , Iyer Arun Kumar , Das Ratnesh , Soni Vandana , Kashaw Sushil Kumar
Published: November 2023

The second most common type of cancer is lung cancer, impacting the human population. Lung cancer
is treated with a number of surgical and non-surgical therapies, including radiation, chemotherapy, and photodynamic treatment. However, the bulk of these procedures are costly, difficult, and hostile to patients. Chemotherapy is distinguished by inadequate tumour targeting, low drug solubility, and insufficient drug transport to the
tumour site. In order to deal with the issues related to chemotherapy, extensive efforts are underway to develop
and investigate various types of nanoparticles, both organic and inorganic, for the treatment of lung cancer. The
subject of this review is the advancements in research pertaining to active targeted lung cancer nano-drug delivery systems treatment, with a specific emphasis on receptors or targets. The findings of this study are expected to
assist biomedical researchers in utilizing nanoparticles [NPs] as innovative tools for lung cancer treatment, offering new methods for delivering drugs and reliable solid ligands.
Bioprospecting of Metabolites from Actinomycetes and their
Applications
Authors: Izhar Syed Khalida , Rizvi Shareen Fatima , Afaq Uzma , Fatima Faria , Siddiqui Saba
Published: November 2023

Actinomycetes are present in various terrestrial and aquatic habitats, predominantly
in the soil rhizosphere, encompassing marine and freshwater ecosystems. These
microorganisms exhibit characteristics that resemble both bacteria and fungi. Numerous
actinomycetes exhibit a mycelial existence and undergo significant morphological transformations.
These bacteria are widely recognized as biotechnologically significant microorganisms
utilized for the production of secondary metabolites. In all, over 45% of all
bioactive microbial metabolites are produced by actinomycetes, which are responsible for
producing around 10,000 of them. The majority of actinomycetes exhibit substantial saprophytic
characteristics in their natural environment, enabling them to effectively decompose
a diverse range of plant and animal waste materials during the process of decomposition.
Additionally, these organisms possess a sophisticated secondary metabolic system,
which enables them to synthesize almost two-thirds of all naturally occurring antibiotics.
Moreover, they can create a diverse array of chemical compounds with medical or agricultural
applications, including anticancer, antiparasitic, and antibacterial agents. This review
aims to provide an overview of the prominent biotechnological domains in which
actinobacteria and their metabolites demonstrate noteworthy applicability. The graphical
abstract provides a preview of the primary sections covered in this review. This paper
presents a comprehensive examination of the biotechnological applications and metabolites
of actinobacteria, highlighting their potential for patent innovations.
Enhancing Nutritional Status in Children with Cerebral Palsy: The Impact of Parental Feeding Rules Counseling and Special Spoon Utilization
Authors: Mansur Arif , Sulistyawati Nining , Sari Ira Mulya
Published: November 2023

The objective of this article is to evaluate the effect on Parental Feeding Rules Counseling and Utilization of Special Spoons on the Nutritional Status for children with cerebral palsy. Children with cerebral palsy (CP) experience nutritional deficiencies resulting from food intake challenges caused by brain and nervous impairments. However, parental implementation, such as counseling on feeding rules and the use of specialized spoons, needs to be improved. Method: A Pre Experimental design with a One Group Pretest-Posttest approach, namely counseling on feeding rules and the utilization of specialized spoons, on the food intake and nutritional status of children with cerebral palsy. The research was conducted at Griya Lare Utami and Special Need Schools 1 Bantul, with a minimum sample size of 18 parent-child pairs with cerebral palsy, selected through purposive sampling. Data analysis was performed using bivariate analysis with the Paired t-test. Result: Child weight and Stature have increase. Conclusion: The intervention programme seemed to increase in the weight and stature indicator, but there has been no change in the nutritional status of BMI-for-age and Length-for-age.
Étude de la variation dans la prononciation française contemporaine locale des toponymes hesbignons composés de Lens: Lens-Saint-Remy [W 48], Lens-Saint-Servais [W 49], Lens-sur-Geer [W 12] et Abolens [W 34]
Authors: Joassin Robin
Published: November 2023

This contribution focuses on the toponyms incorporating “Lens”, in the belgian local region of Hesbaye: Lens-Saint-Remy [W 48], Lens-Saint-Servais [W 49], Lens-sur-Geer [W 12] and Abolens [W 34]. It explores the contemporary local French pronunciations of these toponyms, highlighting the variation that exists in their pronunciation and establishing links between the speakers’ profile and their choice of variant. The study draws on a survey of 348 participants. Initially, the paper revisits some etymological considerations, showing what it has to contribute to the study of the etymology of Lens and proposing a hypothesis for that of “Abolens”: on the other hand, it explores a broader question: it sets out to identify the factors that determine the use of the determiner of a compound toponym in contexts of «language of immediacy».
Predisposing Factors of Nosocomial Infections in Hospitalized Patients in the United Kingdom: Systematic Review
Authors: Isigi Sharon Shivuli , Parsa Ali Davod , Alasqah Ibrahim , Mahmud Ilias , Kabir Russell
Published: November 2023

Background

Nosocomial infections are infections incubating or not present at the time of admission to a hospital and manifest 48 hours after hospital admission. The specific factors contributing to the risk of infection during hospitalization remain unclear, particularly for the hospitalized population of the United Kingdom.

Objective

The aim of this systematic literature review was to explore the risk factors of nosocomial infections in hospitalized adult patients in the United Kingdom.

Methods

A comprehensive keyword search was conducted through the PubMed, Medline, and EBSCO CINAHL Plus databases. The keywords included “risk factors” or “contributing factors” or “predisposing factors” or “cause” or “vulnerability factors” and “nosocomial infections” or “hospital-acquired infections” and “hospitalized patients” or “inpatients” or “patients” or “hospitalized.” Additional articles were obtained through reference harvesting of selected articles. The search was limited to the United Kingdom with papers written in English, without limiting for age and gender to minimize bias. The above process retrieved 377 articles, which were further screened using inclusion and exclusion criteria following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The retained 9 studies were subjected to critical appraisal using the Critical Appraisal Skills Programme (cohort and case-control studies) and Appraisal Tool for Cross-Sectional Studies (cross-sectional studies) checklists. Finally, 6 eligible publications were identified and used to collect the study findings. A thematic analysis technique was used to analyze data extracted on risk factors of nosocomial infections in hospitalized patients in the United Kingdom.

Results

The risk factors for nosocomial infections that emerged from the reviewed studies included older age, intrahospital transfers, cross-infection, longer hospital stay, readmissions, prior colonization with opportunistic organisms, comorbidities, and prior intake of antibiotics and urinary catheters. Nosocomial infections were associated with more extended hospital stays, presenting with increased morbidity and mortality. Measures for controlling nosocomial infections included the use of single-patient rooms, well-equipped wards, prior screening of staff and patients, adequate sick leave for staff, improved swallowing techniques and nutritional intake for patients, improved oral hygiene, avoiding unnecessary indwelling plastics, use of suprapubic catheters, aseptic techniques during patient care, and prophylactic use.

Conclusions

There is a need for further studies to aid in implementing nosocomial infection prevention and control.
Accuracy, Usability, and Adherence of Smartwatches for Atrial Fibrillation Detection in Older Adults After Stroke: Randomized Controlled Trial
Authors: Ding Eric Y , Tran Khanh-Van , Lessard Darleen , Wang Ziyue , Han Dong , Mohagheghian Fahimeh , Mensah Otabil Edith , Noorishirazi Kamran , Mehawej Jordy , Filippaios Andreas , Naeem Syed , Gottbrecht Matthew F , Fitzgibbons Timothy P , Saczynski Jane S , Barton Bruce , Chon Ki , McManus David D
Published: November 2023

Background

Atrial fibrillation (AF) is a common cause of stroke, and timely diagnosis is critical for secondary prevention. Little is known about smartwatches for AF detection among stroke survivors. We aimed to examine accuracy, usability, and adherence to a smartwatch-based AF monitoring system designed by older stroke survivors and their caregivers.

Objective

This study aims to examine the feasibility of smartwatches for AF detection in older stroke survivors.

Methods

Pulsewatch is a randomized controlled trial (RCT) in which stroke survivors received either a smartwatch-smartphone dyad for AF detection (Pulsewatch system) plus an electrocardiogram patch or the patch alone for 14 days to assess the accuracy and usability of the system (phase 1). Participants were subsequently rerandomized to potentially 30 additional days of system use to examine adherence to watch wear (phase 2). Participants were aged 50 years or older, had survived an ischemic stroke, and had no major contraindications to oral anticoagulants. The accuracy for AF detection was determined by comparing it to cardiologist-overread electrocardiogram patch, and the usability was assessed with the System Usability Scale (SUS). Adherence was operationalized as daily watch wear time over the 30-day monitoring period.

Results

A total of 120 participants were enrolled (mean age 65 years; 50/120, 41% female; 106/120, 88% White). The Pulsewatch system demonstrated 92.9% (95% CI 85.3%-97.4%) accuracy for AF detection. Mean usability score was 65 out of 100, and on average, participants wore the watch for 21.2 (SD 8.3) of the 30 days.

Conclusions

Our findings demonstrate that a smartwatch system designed by and for stroke survivors is a viable option for long-term arrhythmia detection among older adults at risk for AF, though it may benefit from strategies to enhance adherence to watch wear.

Trial Registration

ClinicalTrials.gov NCT03761394; https://clinicaltrials.gov/study/NCT03761394

International Registered Report Identifier (IRRID)

RR2-10.1016/j.cvdhj.2021.07.002
Accuracy, Usability, and Adherence of Smartwatches for Atrial Fibrillation Detection in Older Adults After Stroke: Randomized Controlled Trial (Preprint)
Authors: Ding Eric Y , Tran Khanh-Van , Lessard Darleen , Wang Ziyue , Han Dong , Mohagheghian Fahimeh , Mensah Otabil Edith , Noorishirazi Kamran , Mehawej Jordy , Filippaios Andreas , Naeem Syed , Gottbrecht Matthew F , Fitzgibbons Timothy P , Saczynski Jane S , Barton Bruce , Chon Ki , McManus David D
Published: November 2023

BACKGROUND

Atrial fibrillation (AF) is a common cause of stroke, and timely diagnosis is critical for secondary prevention. Little is known about smartwatches for AF detection among stroke survivors. We aimed to examine accuracy, usability, and adherence to a smartwatch-based AF monitoring system designed by older stroke survivors and their caregivers.

OBJECTIVE

This study aims to examine the feasibility of smartwatches for AF detection in older stroke survivors.

METHODS

Pulsewatch is a randomized controlled trial (RCT) in which stroke survivors received either a smartwatch-smartphone dyad for AF detection (Pulsewatch system) plus an electrocardiogram patch or the patch alone for 14 days to assess the accuracy and usability of the system (phase 1). Participants were subsequently rerandomized to potentially 30 additional days of system use to examine adherence to watch wear (phase 2). Participants were aged 50 years or older, had survived an ischemic stroke, and had no major contraindications to oral anticoagulants. The accuracy for AF detection was determined by comparing it to cardiologist-overread electrocardiogram patch, and the usability was assessed with the System Usability Scale (SUS). Adherence was operationalized as daily watch wear time over the 30-day monitoring period.

RESULTS

A total of 120 participants were enrolled (mean age 65 years; 50/120, 41% female; 106/120, 88% White). The Pulsewatch system demonstrated 92.9% (95% CI 85.3%-97.4%) accuracy for AF detection. Mean usability score was 65 out of 100, and on average, participants wore the watch for 21.2 (SD 8.3) of the 30 days.

CONCLUSIONS

Our findings demonstrate that a smartwatch system designed by and for stroke survivors is a viable option for long-term arrhythmia detection among older adults at risk for AF, though it may benefit from strategies to enhance adherence to watch wear.

CLINICALTRIAL

ClinicalTrials.gov NCT03761394; https://clinicaltrials.gov/study/NCT03761394

INTERNATIONAL REGISTERED REPORT

RR2-10.1016/j.cvdhj.2021.07.002
Security Implications of AI Chatbots in Health Care (Preprint)
Authors: Li Jingquan
Published: November 2023

UNSTRUCTURED

Artificial intelligence (AI) chatbots like ChatGPT and Google Bard are computer programs that use AI and natural language processing to understand customer questions and generate natural, fluid, dialogue-like responses to their inputs. ChatGPT, an AI chatbot created by OpenAI, has rapidly become a widely used tool on the internet. AI chatbots have the potential to improve patient care and public health. However, they are trained on massive amounts of people’s data, which may include sensitive patient data and business information. The increased use of chatbots introduces data security issues, which should be handled yet remain understudied. This paper aims to identify the most important security problems of AI chatbots and propose guidelines for protecting sensitive health information. It explores the impact of using ChatGPT in health care. It also identifies the principal security risks of ChatGPT and suggests key considerations for security risk mitigation. It concludes by discussing the policy implications of using AI chatbots in health care.
Using AI-Based Technologies to Help Nurses Detect Behavioral Disorders: Narrative Literature Review (Preprint)
Authors: Fernandes Sofia , von Gunten Armin , Verloo Henk
Published: November 2023

BACKGROUND

The behavioral and psychological symptoms of dementia (BPSD) are common among people with dementia and have multiple negative consequences. Artificial intelligence–based technologies (AITs) have the potential to help nurses in the early prodromal detection of BPSD. Despite significant recent interest in the topic and the increasing number of available appropriate devices, little information is available on using AITs to help nurses striving to detect BPSD early.

OBJECTIVE

The aim of this study is to identify the number and characteristics of existing publications on introducing AITs to support nursing interventions to detect and manage BPSD early.

METHODS

A literature review of publications in the PubMed database referring to AITs and dementia was conducted in September 2023. A detailed analysis sought to identify the characteristics of these publications. The results were reported using a narrative approach.

RESULTS

A total of 25 publications from 14 countries were identified, with most describing prospective observational studies. We identified three categories of publications on using AITs and they are (1) predicting behaviors and the stages and progression of dementia, (2) screening and assessing clinical symptoms, and (3) managing dementia and BPSD. Most of the publications referred to managing dementia and BPSD.

CONCLUSIONS

Despite growing interest, most AITs currently in use are designed to support psychosocial approaches to treating and caring for existing clinical signs of BPSD. AITs thus remain undertested and underused for the early and real-time detection of BPSD. They could, nevertheless, provide nurses with accurate, reliable systems for assessing, monitoring, planning, and supporting safe therapeutic interventions.
Identifying Depression Through Machine Learning Analysis of Omics Data: Scoping Review (Preprint)
Authors: Taylor Brittany , Hobensack Mollie , Niño de Rivera Stephanie , Zhao Yihong , Masterson Creber Ruth , Cato Kenrick
Published: November 2023

BACKGROUND

Depression is one of the most common mental disorders that affects >300 million people worldwide. There is a shortage of providers trained in the provision of mental health care, and the nursing workforce is essential in filling this gap. The diagnosis of depression relies heavily on self-reported symptoms and clinical interviews, which are subject to implicit biases. The omics methods, including genomics, transcriptomics, epigenomics, and microbiomics, are novel methods for identifying the biological underpinnings of depression. Machine learning is used to analyze genomic data that includes large, heterogeneous, and multidimensional data sets.

OBJECTIVE

This scoping review aims to review the existing literature on machine learning methods for omics data analysis to identify individuals with depression, with the goal of providing insight into alternative objective and driven insights into the diagnostic process for depression.

METHODS

This scoping review was reported following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) guidelines. Searches were conducted in 3 databases to identify relevant publications. A total of 3 independent researchers performed screening, and discrepancies were resolved by consensus. Critical appraisal was performed using the Joanna Briggs Institute Critical Appraisal Checklist for Analytical Cross-Sectional Studies.

RESULTS

The screening process identified 15 relevant papers. The omics methods included genomics, transcriptomics, epigenomics, multiomics, and microbiomics, and machine learning methods included random forest, support vector machine, k-nearest neighbor, and artificial neural network.

CONCLUSIONS

The findings of this scoping review indicate that the omics methods had similar performance in identifying omics variants associated with depression. All machine learning methods performed well based on their performance metrics. When variants in omics data are associated with an increased risk of depression, the important next step is for clinicians, especially nurses, to assess individuals for symptoms of depression and provide a diagnosis and any necessary treatment.
Research Trends in Magnetic Resonance Spectroscopy (MRS) in Schizophrenia: Bibliometric Analysis and Visualization (Preprint)
Authors: Zhang Lingfeng , Liu Zhongchun
Published: November 2023

BACKGROUND

Magnetic resonance spectroscopy (MRS) is a non-invasive imaging technique that measures metabolite concentrations in the brain. Schizophrenia is a complex psychiatric disorder characterized by hallucinations, delusions, and cognitive impairments. MRS can help elucidate the neurochemical changes underlying schizophrenia.

OBJECTIVE

This study aims to leverage bibliometric tools to analyze the trends of MRS application in schizophrenia research from 1997 to 2022, shedding light on its impact within academia and public interest.

METHODS

This study provides a synopsis of the Web of Science (WOS) Core Collection concerning the link between Magnetic Resonance Spectroscopy (MRS) and the molecular and biochemical alterations in Schizophrenia, covering the period from 1997 to 2022. The assembly and scrutiny of all data were facilitated using EndNote™ software. With the bibliometrics tool from the R package, our research accomplished data extraction and visualization. Keyword citation bursts were generated and rendered using CiteSpace. A map signifying the dispersion of countries and regions was sketched in SCImago. The Standard Competition Ranking method was employed for rankings. Co-authorship, co-citation, and co-occurrence were dissected using VOSviewer.
An examination of co-authorship revealed that 113 institutions were organized into 12 clusters, each representing a distinct country or region. The findings thereby underscore the need for enhanced intercontinental collaborations among these institutions. The section on core authors spotlighted shifts among the most prolific authors over time. A keyword analysis unveiled 25 suddenly prominent keywords. Moreover, co-citation analysis of references highlighted the frequency and centrality of citations pertaining to the cornerstone publications in the field.

RESULTS

After the exclusion of duplicate entries, book chapters, conference proceedings, and articles with undetermined age, 1,322 entries were selected for inclusion, while 192 were dismissed. A trend was noticed in the yearly publication pattern, with a swift rise in the number of publications from 1997 to 2022. The geographical distribution portrayed a substantial disparity in the number of publications between the United States, England, and other countries, with Europe and North American institutions predominantly leading in this domain.

CONCLUSIONS

The research on nuclear magnetic resonance spectroscopy analysis of schizophrenia has been in a hot spot since 1999. Our research results indicate that the United States and the United Kingdom are dominant. In addition, intercontinental cooperation should be strengthened, and future research hotspots may focus more on the hallucinatory symptoms and neurotransmitter metabolism of schizophrenia patients, as well as the in-depth exploration of new molecular biochemical mechanisms, such as iron death, copper death, and oxidative stress, which may provide a basis for further research.
Correction: Identifying Predictors of Nursing Home Admission by Using Electronic Health Records and Administrative Data: Scoping Review (Preprint)
Authors: Han Eunkyung , Kharrazi Hadi , Shi Leiyu
Published: November 2023

UNSTRUCTURED

REMOVE
PENGEMBANGAN MEDIA VIDEO ANIMASI BERBASIS POWTOON TERHADAP KEPERCAYAAN DIRI SISWA KELAS VIII MTS AL QODIRIYAH
Authors: Sandiani Sonia , Rukanda Nandang , Alawiyah Tuti
Published: November 2023

This research aimed to discover the appropriateness of powtoon-based animation videomedia on the MTS Alqodiriyah students’ confidence, who are in adolescence accordingtotheirage;thiseraiscrucialfortheteenagerstodeveloptheirconfidence.The research and development technique was employed in this study (RnD). The participants in this study were 7 eighth-grade MTS Alqodiriyah students. The validity product test was conducted byproduct experts, material experts, school practitioners, and students’ responses on thepowtoon-basedanimationvideomedia.The research's findings indicated that the creation of animated video media based on Powtoon obtained 96% of the results indicating that the product is appropriate and falls under the proper category, making it useful for the implementation of guidance and counseling services.
Ko. Fluid Practices.
Authors: Sergio Patricio
Published: November 2023

Ko = water in Mapundungun (Mapuche language).
The reflection revolves around how we divide the waters in time-based media practices in the current context of environmental emergency + war. The analysis begins inspired by the Mapuche people about interconnectedness with rivers and lakes, raising a question about art practices today. Ko's idea is based on how water flows from the sides (positions, political strategies, visions) and divides territories. How to make performance art sustainable? To answer this question, a capsule is presented around the ecology of time-based media as a fluid art practice. To understand in three steps this observation selected exponents from around the world and Austria helps to make a final selection of three performance artists living and working in Vienna, observed as different currents of one sea with leitmotiv and policy paths. The aim is to use this classification to speculate on how they could improve sustainability in the next decade. Ko speculates on how practices use these territories divided as a sea with currents. Where bodies could achieve the awareness needed especially in terms of water crisis scarcity and safe access. The final thought claims attention to fluid thinking to find solutions and build a sustainable community.
The weft. Time-based media arts and cross-art practices.
Authors: Sergio Patricio
Published: November 2023

The weft is an article that requests to hold time and attention about time-based art practices, especially the ones that rely on time as a medium with the usage of technology and multimedia formats to be presented live in the case of performance art, for example. The article is more than a dialogue of a theory, it is a speculation about the future of these practices in terms of cultural impact and sustainability. The questions and speculations posed a question about the status of these practices within the facilitation in educators and practitioners related to Time.
Improving the Livelihood of Poultry Farmers in India through Contract Farming: How Effective?
Authors:   New Frontiers LLC, Gunchinsuren Enkhtuvshin , Kiefer Manfred ,   Asian Development Bank, Abeleda Christian ,   Asian Development Bank
Published: November 2023

This brief explores how efficient private sector-led contract poultry farming—where a farmer produces exclusively for one contractor—can boost the livelihoods of small-scale Indian farmers and support sustainable rural development. Noting the rapid growth of India’s poultry sector, the brief looks at how contract farmers benefit from economies of scale, shorter poultry farming cycles, and higher labor and capital productivity. Drawing on data from farmers in Uttar Pradesh and Rajasthan, it analyzes the impact of the pandemic, looks at the barriers to working with a major producer, and shows how contract farming can reduce a poultry farmer’s risk exposure.
Functionalized carbon nanostructures as temozolomide carriers: Physicochemical and biopharmaceutical characterization
Authors: Milenkovska Radmila , Geskovski Nikola , Makreski Petre , Grozdanov Anita , Popovski Emil , Petrushevski Gjorgji , Simonoska-Crcarevska Maja , Mladenovska Kristina
Published: November 2023

In this study, temozolomide (TMZ), a drug used in the treatment of anaplastic astrocytoma and glioblastoma multiforme, was incorporated in multiwalled carbon nanotubes (MWCNTs) and hybrid carbon nanotubes with graphene (MWCNTs-G) functionalized by polyethylene glycol (PEG). The aim was to evaluate the potential of these nanocarriers for targeted delivery and sustained release of TMZ in brain tumor cells. Oxidized MWCNTs and MWCNTs-G were noncovalently functionalized with PEGs of different molecular weights and subsequently loaded with TMZ following standard procedures. Thorough physicochemical and biopharmaceutical characterization of the TMZ-loaded carbon nanocarriers pointed to high encapsulation efficacy (up to 67%) and drug loading (up to 18% out of 25% theoretical value) and homogeneous particle size distribution, with z-average (160 to 300 nm) and zeta potential (?31 to ?21 mV) of the particles adequate for crossing the blood-brain-tumor-barrier (BBTB) and entering into the tumor cells. Successful functionalization and TMZ loading were confirmed by SEM and TEM images, UV-Vis absorption, infrared and Raman spectroscopy, and TGA analyses. Sustained release of TMZ from the carbon nanocarriers was observed in vitro. The presented findings form a fundamental platform for further investigation of these formulations against different types of glioma cells and in adequate animal models.
High Doses of Exogenous Glucagon Stimulate Insulin Secretion and Reduce Insulin Clearance in Healthy Humans
Authors: Gray Sarah M. , Goonatilleke Elisha , Emrick Michelle A. , Becker Jessica O. , Hoofnagle Andrew N. , Stefanovski Darko , He Wentao , Zhang Guofang , Tong Jenny , Campbell Jonathan , D’Alessio David A.
Published: November 2023

Glucagon is generally defined as a counterregulatory hormone with a primary role to raise blood glucose concentrations by increasing endogenous glucose production (EGP) in response to hypoglycemia. However, glucagon has long been known to stimulate insulin release, and recent preclinical findings have supported a paracrine action of glucagon directly on islet β-cells that augments their secretion. In mice, the insulinotropic effect of glucagon is glucose dependent and not present during basal euglycemia. To test the hypothesis that the relative effects of glucagon on hepatic and islet function also vary with blood glucose, a group of healthy subjects received glucagon (100 ng/kg) during fasting glycemia or experimental hyperglycemia (∼150 mg/dL) on 2 separate days. During fasting euglycemia, administration of glucagon caused blood glucose to rise due to increased EGP, with a delayed increase of insulin secretion. When given during experimental hyperglycemia, glucagon caused a rapid, threefold increase in insulin secretion, as well as a more gradual increase in EGP. Under both conditions, insulin clearance was decreased in response to glucagon infusion. The insulinotropic action of glucagon, which is proportional to the degree of blood glucose elevation, suggests distinct physiologic roles in the fasting and prandial states.

Article Highlights
Critical Evaluation of Indices Used to Assess β-Cell Function
Authors: Cao Chao , Koh Han-Chow E. , Reeds Dominic N. , Patterson Bruce W. , Klein Samuel , Mittendorfer Bettina
Published: November 2023

The assessment of β-cell function, defined as the relationship between insulin secretion rate (ISR) and plasma glucose, is not standardized and often involves any of a number of β-cell function indices. We compared β-cell function by using popular indices obtained during basal conditions and after glucose ingestion, including the HOMA-B index, the basal ISR (or plasma insulin)-to-plasma glucose concentration ratio, the insulinogenic and ISRogenic indices, the ISR (or plasma insulin)-to-plasma glucose concentration areas (or incremental areas) under the curve ratio, and the disposition index, which integrates a specific β-cell function index value with an estimate of insulin sensitivity, between lean people with normal fasting glucose (NFG) and normal glucose tolerance (NGT) (n = 50) and four groups of people with obesity (n = 188) with 1) NFG-NGT, 2) NFG and impaired glucose tolerance (IGT), 3) impaired fasting glucose (IFG) and IGT, and 4) type 2 diabetes. We also plotted the ISR-plasma glucose relationship before and after glucose ingestion and used a statistical mixed-effects model to evaluate group differences in this relationship (i.e., β-cell function). Index-based group differences in β-cell function produced contradicting results and did not reflect the group differences of the actual observed ISR-glucose relationship or, in the case of the disposition index, group differences in glycemic status. The discrepancy in results is likely due to incorrect mathematical assumptions that are involved in computing indices, which can be overcome by evaluating the relationship between ISR and plasma glucose with an appropriate statistical model. Data obtained with common β-cell function indices should be interpreted cautiously.

Article Highlights
Transferensi dalam Proses Konseling
Authors: Saputra Indra , Hariko Rezki , Karneli Yeni
Published: November 2023

Transference can be an obstacle and help that counselors get from their clients. However, transference that is too strong from the client will also hinder the relationship in the counseling process. For this reason, a counselor must know what the causes and strategies are to resolve transference in the counseling relationship. Therefore, the purpose of this study is to find out how transference is in the counseling process, to obtain data regarding this purpose, the researcher uses a qualitative method with a descriptive narrative approach with online data collection. The results of this study are transference is a projection of feelings from the client to the counselor, this projection of feelings occurs because of the blurring of ethical standards or boundaries set by the counselor in the counseling process, for that we need several strategies to overcome them.
EXPRESSÕES AFETIVAS DE PROFESSORAS DA EDUCAÇÃO INFANTIL NO RETORNO AO ENSINO PRESENCIAL
Authors: Mota Bruno de Oliveira Sales , Santos Geandra Cláudia Silva
Published: November 2023

A Educação Infantil possui extrema importância como primeira etapa da Educação Básica, sendo grandemente prejudicada pela pandemia da covid-19. Diante disso, este trabalho objetiva investigar as expressões afetivas de professoras da Educação Infantil da rede de ensino público de um município cearense, no retorno às atividades presenciais após o período de isolamento pandêmico da covid-19. Trata-se de um Estudo de Campo de abordagem qualitativa, desenvolvido com dez professoras de Educação Infantil. Como resultados, percebeu-se por parte das professoras: uma coexistência de emoções e sentimentos diversos em relação ao retorno do ensino presencial; reflexões de caráter filosófico ou religioso sobre o sentido da vida, oriundas do período pandêmico; percepção de uma maior valorização da figura do professor por parte da família após o isolamento; conflito entre a natureza educativa da Educação Infantil e as limitações impostas pela covid-19; entendimento do domínio das tecnologias como momento de aprendizagem e superação profissional.
MOVIMENTO NA INFÂNCIA: desenvolvimento e Educação Infantil com enfoque teórico-prático
Authors: Matos Suellen Pammela Costa , Coelho Andréa Saldanha Pinheiro , Silva Susy de Sousa Canuto
Published: November 2023

A criança e o movimento são duas coisas indissociáveis. Essa relação é que possibilita ao indivíduo interagir com o meio em que vive, conhecer e experimentá-lo, relacionando-se e tornando-se parte dele. O artigo apresentado teve como objetivo analisar a importância do movimento para o desenvolvimento das crianças de zero a seis anos, fundamentando-se nos principais teóricos do desenvolvimento humano e como ele pode ser trabalhado através de vivências significativas na educação infantil. Percebeu-se que um bom desenvolvimento motor, sólido e bem explorado é parte fundamental para tornar as aprendizagens, sociais e escolares, mais dinâmicas, contextualizadas e prazerosas para as crianças.
PENGARUH BUDAYA ORGANISASI DAN MOTIVASI KERJA TERHADAP KINERJA PEGAWAI PADA DINAS PENDAPATAN DAERAH KABUPATEN LAMPUNG UTARA
Authors: Lubis Dharmawan
Published: November 2023

Abstrak

Penelitian ini bertujuan untuk mengetahui pengaruh secara sendiri maupun bersama-sama budaya organisasi dan motivasi kerja terhadap kinerja pegawai pada Dinas Pendapatan Daerah Kabupaten Lampung Utara. Jenis penelitian yang digunakan dalam penelitian ini merupakan penelitian survey dengan menggunakan pendekatan analisis kuantitatif dengan variabel bebas yaitu Budaya Organisasi (X1), Motivasi Kerja (X2) dan Kinerja Pegawai (Y). Metode pengumpulan data menggunakan daftar wawancara, lembar observasi, kuesioner dan studi kepustakaan, dengan populasi sebanyak 64 responden, yaitu pegawai Dinas Pendapatan Daerah Kabupaten Lampung Utara. Berdasarkan hasil penelitian maka diketahui baik secara partial atau sendiri-sendiri dan secara simultan atau bersamasama budaya organisasi dan motivasi kerja memiliki pengaruh terhadap kinerja pegawai di Dinas Pendapatan Daerah Kabupaten Lampung Utara. Kemudian diantara kedua variabel tersebut yang paling dominan mempengaruhi kinerja adalah motivasi kerja. Kata kunci: Budaya Organisasi , Motivasi Kerja, dan Kinerja Pegawai.
PENGARUH EMPLOYEE ENGAGEMENT DAN BUDAYA ORGANSASI TERHADAP KINERJA PEGAWAI PADA BADAN KESATUAN BANGSA DAN POLITIK KABUPATEN LAMPUNG TENGAH
Authors: Rozana Rozana , Mazni Afdal , Suhada Bambang
Published: November 2023

Tujuan penelitian ini adalah untuk memperoleh data dan mengetahui pengaruh positif employeeengagement dan budaya organisasi terhadap kinerja pegawai pada badan kesatuan bangsa dan politik kabupaten lampung tengah. Teknik pengambilan sampel yaitu accidental samplingdidapat 150 sampel. Metode yang digunakan adalah mix methoddengan pendekatan kuantitatif yaitu dengan wawancara atau kuesioner. Dalam penelitian ini alat analisis yang digunakan adalah analisis regresi linier berganda untuk mengetahui variabel dependen dan independen dengan alat bantu program SPSS 25 for windows.Hasil penelitian yang dilakukan oleh peneliti menunjukan bahwa ada pengaruh employeeengagaement dan budaya organisasi terhadap kinerja pegawai pada badan kesatuan bangsa dan politik kabupaten lampung tengah.. Berdasarkan analisis data diperoleh Fhitung42.855> 0,000 yang ditunjukan dengan regresi linier dengan koefisien determinasi (R2) 0,716 yang berarti kinerja pegawai dipengaruhi oleh variabel employeeengagement dan budaya organisasi kerja sebesar 71,6% dan sisanya 28,4% dipengaruhi oleh faktor lain.
PENGARUH BAURAN PEMASARAN TERHADAP KEPUTUSAN PELANGGAN DALAM MENGGUNAKAN LAYANAN TRANSPORTASI ONLINE GOJEK (Studi Kasus Pada Badan Kesatuan Bangsa dan Politik Kota Metro)
Authors: Asmariyana Asmariyana , Suharto Suharto , Suhada Bambang
Published: November 2023

Penelitian ini dilatar belakangi oleh keresahan masyarakat perkotaan yang terjebak dalam kemacetan lalu lintas yang begitu padat. Sebagian masyarakat perkotaan lebih banyak beraktivitas di luar rumah sehingga membutuhkan alat transportasi yang praktis dan cepat agar dapat terhindar dari kemacetan lalu lintas. Alat transportasi yang dimaksud adalah ojek. Dengan kemajuan teknologi informasi melalui aplikasi Gojek yang dibangun oleh PT Aplikasi Karya Anak Bangsa, Gojek memfasilitasi kebutuhan masyarakat untuk mendapatkan alat transportasi ojek secara online. Aplikasi ini mempertemukan antara driver dengan calon penumpang di tempat mereka memesan jasa angkutan ojek. Kesuksesan aplikasi Gojek dalam menjalankan bisnis layanan transportasi online sehingga diminati oleh konsumen merupakan gambaran keberhasilan dalam pemanfaatan strategi pemasaran. Setidaknya strategi pemasaran yang di gunakan adalah kombinasi dari bauran pemasaran (produk, harga, distribusi dan promosi). Tujuan penelitian ini adalah untuk mengetahui pengaruh variabel produk, harga, promosi, dan distribusi/tempat terhadap keputusan penggunaan aplikasi Gojek oleh pegawai pada Badan Kesatuan Bangsa dan Politik Kota Metro (Badan Kesbangpol). Populasi yang digunakan dalam penelitian ini adalah seluruh pegawai pada Badan Kesatuan Bangsa dan Politik Kota Metro yang berjumlah 30 orang. Pemilihan/penentuan sampel pada penelitian ini dilakukan dengan menggunakan metode sampel jenuh (saturation sampling), yaitu sebanyak 30 orang. Adapun teknik pengumpulan data yang digunakan dalam penelitian ini adalah wawancara dan survey. Instrumen penelitian yang digunakan dalam penelitian ini adalah kuesioner menggunakan skala likert 1 – 4. Jenis penelitian ini adalah penelitian kuantitatif. Desain penelitian yang digunakan adalah observasional analitik. Teknik analisis data berupa analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa variabel produk memliki pengaruh yang positif dan signifikan terhadap variabel keputusan penggunaan aplikasi Gojek (Sig. 0,014). Variabel harga memiliki pengaruh yang negatif dan signifikan terhadap variabel keputusan penggunaan aplikasi Gojek (Sig. 0,016). Variabel promosi memiliki pengaruh yang positif dan signifikan terhadap variabel keputusan penggunaan aplikasi Gojek (Sig. 0,003). Variabel tempat/distribusi memiliki pengaruh yang positif dan signifikan terhadap variabel keputusan penggunaan aplikasi Gojek (Sig. 0,004). Variabel produk, harga, promosi, dan tempat secara simultan (bersama) memiliki pengaruh yang signifikan terhadap variabel keputusan penggunaan aplikasi Gojek (Sig. 0,000).
PENGARUH SELF EFFICACY DAN KINERJA DENGAN PRODUKTIVITAS KERJA PEGAWAI NEGERI SIPIL PADA DINAS KOPERASI, USAHA KECIL MENENGAH DAN PERDAGANGAN KABUPATEN LAMPUNG TENGAH
Authors: Asmalia Desita , Suharto Suharto , Mazni Afdal
Published: November 2023

Sumber daya manusia tidak dapat dipungkiri merupakan salah satu aset terpenting bagi organisasi. Peranan sumber daya manusia bagi organisasi tidak hanya dilihat dari hasil produktivitas kerja tetapi juga dilihat dari kualitas kerja yang dihasilkan. Oleh karenanya kinerja pegawai merupakan hal yang patut mendapat perhatian penting dari pihak organisasi. Sumber daya manusia yang ada juga perlu dikelola dan dibina agar mereka merasa puas dalam melaksanakan pekerjaannya sehingga mampu berkontribusi untuk kinerja dan kemajuan organisasi tersebut. Kinerja yang diaktualisasi oleh pegawai juga didukung oleh beberapa faktor antara lain self esteem (keyakinan nilai sendiri berdasarkan evaluasi diri secara keseluruhan), self efficacy (keyakinan seseorang mengenai kemampuan dan peluangnya untuk berhasil mencapai tugas tertentu). Self esteem yang dimiliki seseorang akan menumbuhkan suatu kekuatan dalam melakukan yang terbaik dalam kinerjanya sesuai tugas dan tanggung jawabnya. Populasi sebanyak 92 pegawai dengan sampel yang digunakan sebanyak 91 responden. Pengambilan data ini dengan mengunakan quisioner sebagai alat bantu penelitian. Hasil analisis yang diperoleh dalam penelitian ini sebagai berikut: 1) Ada pengaruh signifikan antara self efficacy terhadap produktivitas kerja Pegawai Negeri Sipil Pada Dinas Koperasi, Usaha Kecil Menengah dan Perdagangan Kabupaten Lampung Tengah. 2) Ada pengaruh signifikan antara kinerja terhadap produktivitas kerja Pegawai Negeri Sipil Pada Dinas Koperasi, Usaha Kecil Menengah dan Perdagangan Kabupaten Lampung Tengah. 3) Berdasarkan hasil uji F dengan perhitungan SPSS dimana nilai F menunjukan terdapat pengaruh secara bersama-sama antara self efficacy dan kinerja terhadap produktivitas kerja Pegawai Negeri Sipil Pada Dinas Koperasi, Usaha Kecil Menengah dan Perdagangan Kabupaten Lampung Tengah. Koefisien nilai R menunjukan besar derajat keeratan pengaruh antaraself efficacy dan kinerja terhadap produktivitas kerja Pegawai Negeri Sipil Pada Dinas Koperasi, Usaha Kecil Menengah dan Perdagangan Kabupaten Lampung Tengah tergolong kategori sedang. Dengan simpulan bahwa hasil penelitian terdapat pengaruh self efficacy dan kinerja terhadap produktivitas kerja Pegawai Negeri Sipil Pada Dinas Koperasi, Usaha Kecil Menengah dan Perdagangan Kabupaten Lampung Tengah
PENGARUH BEBAN KERJA DAN KONFLIK KERJA TERHADAP KINERJA PEGAWAI DI SEKOLAH TINGGI AGAMA ISLAM (STAI) TULANG BAWANG LAMPUNG
Authors: Sepridayana Sepridayana , Suharto Suharto , Febriyanto Febriyanto
Published: November 2023

Tujuan penelitian ini adalah untuk menganalisis: (1) Pengaruh beban kerja terhadap kinerja pegawai di STAI Tulang Bawang Lampung; (2) konflik kerja terhadap kinerja pegawai di STAI Tulang Bawang Lampung; dan (3) Pengaruh beban kerja dan konflik kerja terhadap kinerja pegawai STAI Tulang Bawang Lampung. Populasi sebanyak 55 Pegawai dengan penarikan sampel menggunakan sampel jenuh.maka sampel penelitian ini sama dengan populasi adalah semua pegawai STAI Tulang Bawang sebanyak 55 pegawai. Hasil analisis yang diperoleh adalah (1) Terdapat pengaruh positif dan signifikan beban kerja terhadap kinerja pegawai di STAI Tulang Bawang Lampung. (2) Terdapat pengaruh positif dan signifikan konflik kerja terhadap  kinerja pegawai STAI Tulang Bawang Lampung. dan (3) Terdapat pengaruh positif dan signifikan beban kerja dan konflik kerja secara simultan terhadap kinerja pegawai STAI Tulang Bawang Lampung.. Hasil penelitian ini mengindikasikan bahwa Semakin banyak beban kerja dan konflik kerja maka akan semakin meningkat kinerja pegawai. Simpulan dari hasil penelitian ini adalah beban kerja secara parsial berpengaruh positif dan siginifikan terhadap kinerja pegawai, konflik kerja secara parsial ada pengaruhpositif dan signifikan terhadap kinerja pegawai dan secara simultan beban kerja dan konflik kerja berpengaruh positif terhadap kinerja pegawai Sekolah Tinggi Agama Islam Tulang Bawang Lampung.