bluuebunny/crossref_metadata_2025 huggingface dataset:
A Customized Open Journal System for the University of the Immaculate Conception
Authors: Emberda Eric John G.
Published: February 2016

With the continuous improvement of its research capabilities, the University of the Immaculate Conception (UIC) is taking a step higher in the advancement of its tools for research, specifically the implementation of the Open Journal System (OJS). This system allows UIC to have its research journals be published online, indexed, and able to comply with international standards. Although OJS is a free and open source tool that is readily implementable, it still needs for customization to match the university’s LW3 system to ensure the consistency of user records and avoid redundancy of data between the two systems. This action research was undertaken to custom-fit OJS for UIC for proper implementation. It followed the Rational Unified Process (RUP) in the customization process which is a proven process model created by IBM. Its stages involved Inception, Elaboration, Construction, and Transition. In the elaboration stage, an analysis of the structure of OJS was made where classes in the Model-View-Controller (MVC) architecture of OJS were identified to have the need for modifications. This was developed in the construction stage. A series of testing was done in the transition stage. Despite the difficulties encountered in matching LW3 and OJS, it was still successfully integrated in the system.
 

Keywords:  Customized Open Journal System, constructive research approach, research journal, University of the Immaculate Conception, Philippines

 
Knowledge and Attitude on HIV and AIDS: Standpoint of College Students of the University of the Immaculate Conception
Authors: Galindo Maribeth Q.
Published: February 2016

HIV/AIDS has been a global concern. According to UNAIDS, the Philippines is one of the seven countries in the world and the only country in Southeast Asia which reported an increasing trend in the number of people infected with HIV. Thus, this investigation determined the knowledge and attitude of college students of the University of the Immaculate Conception on Human Immunodeficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS). This is a correlation study which examined whether their knowledge on HIV/AIDS has something to do with their attitude towards it, basing on the premise that the more informed a person is on matters related to HIV/AIDS, the more appropriate his or her attitude towards it is formed. A survey using an adapted questionnaire was conducted to 380 randomly selected college students of the University of the Immaculate Conception, Davao City, Philippines. Findings of the study revealed a high level of knowledge on HIV/ AIDS and a moderately positive attitude towards all the aspects involved in dealing with these health issues. Subjecting the data to Pearson r analysis, it was found that there is a significant moderate relationship between the knowledge and attitude on HIV/AIDS from the standpoint of the college students.

 

Keywords: Health education, knowledge, attitude, HIV/AIDS, correlation study, University of the Immaculate Conception, Davao City, Philippines

 
Features of the state of health and physical development of school students of St. Petersburg
Authors: Suslova Galina Anatolyevna , Lvov Sergey Nikolayevich , Zemlyanoy Dmitriy Alekseyevich
Published: February 2016

In article are given the results of research of a state of health and physical development of school students. It’s revealed that 59.9 % of schoolboy have harmonious physical development. Power opportunities of every third school student lie within values “below an average”. Dependences of physiometric indicators on a sex and age are analyzed.
MOLECULAR DIAGNOSTICS OF TUBEROUS SCLEROSIS
Authors: Yanus Grigoriy Arkadyevich , Suspitsyn Yevgeniy Nikolayevic , Dorofeyeva Marina Yuryevna , Imyanitov Yevgeniy Naumovich
Published: February 2016

Tuberous sclerosis is a hereditary disease of phakomatoses group, characterized by the development of multiple hamartomas of brain, eyes, skin and visceral organs. Diagnostics of tuberous sclerosis requires identification of pathogenic mutations within TSC1 or TSC2 genes. Here we present a description of clinical case of tuberous sclerosis followed by detection of the causative mutation.
Some features of staged treatment of cataract in children
Authors: Nikitina Tatyana Nikolayevna
Published: February 2016

25 patients 5–17 years old after primary and secondary implantation of intraocular lenses were examined. The least reactive course of the postoperative period, in combination with the best functional result, was received using intraocular lenses AcrySof (Alcon). The best functional results (visual acuity and binocularity) were received at secondary implantation of the intraocular lenses, executed to children over 7 years old with aphakia who received active pleoptic treatment before and after operation.
Сomparative effect of artificial tear drug usage in patients with «dry eye» syndrome and chronic blepharitis
Authors: Prozornaya Lyudmila Petrovna , Brzheskiy Vladimir Vsevolodovich
Published: February 2016

During recent years, the problem of treatment «dry eye» syndrome in patients with chronic blepharitis is very important. But until there are no rational standards how to treat such patients. We investigated group of 44 adults with the chronic blepharitisand concomitant dry eye syndrome. In present article, рresented are the treatment results of artificial tear drug usage in patient with «dry eye» syndrome and chronic blepharitis.
Characteristics of clinical manifestations of Marfan syndrome in childrenand complications of surgical treatment of lens luxation
Authors: Toshpulatova Arofat Ziyavutdinovna
Published: February 2016

The most common ocular clinical signs of Marfan syndrome are lens luxation (46.16 %) and cataract (26.92 %), which during their progression are complicated by secondary glaucoma, lenticular myopia and strabismus. Discussed information indicates to the need to improve the traditional methods of surgery in children with ocular manifestations of Marfan syndrome in order to reduce the risk of intraand postoperative complications.
CHARACTERISTICS OF RESPIRATORY SUPPORT IN ANESTHESIA OF ENDOLARYNGEAL OPERATIONS
Authors: Kolotilov Leonid Vadimovich , Pavlov Vladimir Yevgenyevich
Published: February 2016

The article presents the practical aspects of jet ventilation (JV) methods usage during the anesthesiological support of endolaryngeal operations. The recommendations for the selection of JV methods and regimes subject the form of pathologic object, degree of its manifestation, localization, and also mode of endosurgical operation are given. The possibilities of JV complications prevention are discussed.
Singularities of haemorrhagic syndrome in children with native and acquired deficiencies of von Willebrand factor
Authors: Pshenichnaya Kseniya Ivanovna , Lyugayev Yegor Viktorovich , Golovina Olga Georgiyevna
Published: February 2016

Deficiencies of content in blood and activity of von Willebrand factor can be inborn or acquired with diseases of different nature. Acquired deficiencies of von Willebrand factor or acquired von Willebrand syndrome in children have been described in several clinical studies. This research paper contains data on clinical manifestation and dynamics of haemorrhagic syndrome in 30 children between 13 months and 18 years of age with acquired von Willebrand factor, suffering from different types of pathology. Similarly, clinical manifestations and dynamics of angiostaxis have been studied in 33 children with von Willebrand disease. It has been determined that clinical manifestations of microcirculatory angiostaxis are the same for children from both groups; however, children with acquired von Willebrand syndrome showed dominating limited numbers of haemorrhagical symptoms that were shorter in duration and less intense. Besides, hematomic component of haemorrhagic syndrome was absent. Eventually, accompanied by positive dynamic of the underlying disease, relapses of haemorrhagic syndrome cease, which does not happen in case of the patients with von Willebrand disease.
The state of the blood flow in patients with the adenomyosis
Authors: Arutyunyan Arutyun Felixovich , Gaidukov Sergey Nikolaevich , Kostushov Yevgeniy Vasilevich
Published: February 2016

The purpose of this study was to evaluate the specific features of uterine blood flow during adenomyosis to select appropriate treatment. 59 women were observed, among whom 49 suffered adenomyosis and 10 were healthy. Out of the 49 women in 34 was confirmed adenomyosis II–III degree of postoperative morphological studies, and in 15 patients — first degree adenomyosis after biopsy. In patients with first grade adenomyosis observed low-resistant uterine blood flow. However, in patients with adenomyosis II–III degree — high-resistant blood flow in uterine arteries and in vessels of the myometrium.
Genetic and Epigenetic Aspects of Obessity and Metabolic Syndrom in Child
Authors: Tyrtova Ludmila Viktorovna , Parshina Natalja Vladimirovna , Skobeleva Kristina Vladimirovna
Published: February 2016

In a review article analyzes the role of heredity in the occurrence of obesity and metabolic syndrome. Debut of hyperphagia and severe obesity from early childhood are typical for monogenic forms and syndromes. Many nonspecific candidate-genes in combination form a polygenic basis for the accumulation of excess body fat, especially under the influence of irrational diet and low physical activity. Examined the role of epigenetic factors in the individual genetic variants in fetus, predisposing to obesity and metabolic syndrome after birth. Discuss the possibilities of early prevention of obesity and metabolic syndrome.
System enzyme therapy for the children and teenagers
Authors: Sternin Yuriy Igorevich , Mikhailov Igor Borisovich
Published: February 2016

One of the perspective treatment methods in pediatric practice is system enzyme therapy. The action mechanism of system enzyme therapy (Wobenzyme) was represented, such as inflations on the inflammatory process, immune system, vascular thrombocyte homeostasis. Separately examine the problems of Wobenzyme and antibiotic interaction, and also clinical researches of several diseases in pediatrics.
Peculiarities of the syndrome of ‘‘dry eye’’ in children with congenital glaucoma
Authors: Vorontsova Olga Anatolievna , Brzheskiy Vladimir Vsevolodovich
Published: February 2016

Authors analyze the results of examination of 33 children with congenital glaucoma in the age from 3 till 17 years old. Two groups were sorted out. Children of the first group were treated with 0.5 % timolol maleat, the minimal duration of treatment was 6 months (6 months–7 years). The second group included patients with congenital glaucoma without conservative treatment. The control group included 226 healthy children in the age from 3 till 17 years old without complaints and symptoms of dry eye. The decrease of tear break-up time was revealed in all children with congenital glaucoma. In patients receiving β-blocking treatment the decrease of basal tear secretion was also detected.
PATHOGENETIC MECHANISMS OF STRESS CARDIOMYOPATHY IN HIGH-QUALIFIED SPORTSMEN
Authors: Vasilenko Vladimir Stanislavovich , Semenova Yuliya Borisovna
Published: February 2016

Hormonal and immune disturbances were investigated in high-qualified sportsmen during different periods of training cycle. Changed correlation of cortisol and testosterone levels was revealed. This fact is directly associated with significant immune dysfunction of Tand B-systems which leads to progression of cellular and humoral autoimmune reactions. These changes occure in the transitional period of the training cycle. It was confirmed that autoimmune reactions may be considered as the earliest markers of stress cardiomyopathy. Those sportsmen who develop these reactions must be classified as a risk-group.
Clinical features and rehabilitation of children with protein-energy malnutrition from socially disadvantaged families
Authors: Sokolova Margarita Ivanovna , Akimov Alexandr Anatolievich , Shishkina Yuliya Albertovna , Novozhilova Marina Valentinovna , Alekhina Galina Gennadievna
Published: February 2016

Conducted research to identify the frequency and the main causes of protein-energy malnutrition in children without parental care. Investigated the state of the vital systems (nervous, cardiovascular, digestive). Presented the efficiency of rehabilitation of children with malnutrition using probiotic Laminolakt “Chernichka”, confirmed the safety of its use.
FEATURES OF DIAGNOSTICS AND TREATMENT OF CHRONIC INFECTIOUS-INFLAMMATORY DISEASES OF DIFFERENT LOCALIZATION
Authors: Grigoreva Olga Pavlovna , Savenkova Nadezhda Dmitrievna , Losovskaya Marina Eduardovna
Published: February 2016

In the article are presented peculiarities of the course of kidney disease in children infected with Mycobacterium tuberculosis. Discussed in detail issues of tubulointerstitial nephropathy, AA-amyloidosis, nephrotic syndrome in children with tuberculosis infection. Presents modern concepts on the mechanism of nephrotoxicity of different groups of anti-TB drugs.
Prolonged low-grade fever in children: modern aspects of diagnostic search
Authors: Khramtzova Elena Georgievna , Muraveva Nataliya Nikolaevna , Kliorina Tatyana Alexandrovna , Akimov Alexandr Anatolievich
Published: February 2016

The lecture presents modern representations about etiopathogenesis and classification of the protracted subfebrile fever in children, the main features of the methodology of children examination are taken up. There are described the mechanisms of thermoregulation in early chidhood. The consecutive algorithm of diagnostic search is presented in order to determine the reasons of the protracted subfebrile fever. These reasons correlates with background microsemiology and age of the child. In the separate block there are presented the short description and methods of diagnostics of the endemic diseases. The separate block of the general anamnestic risk factors of the protracted subfebrile fever in childhood is allocated. In the separate block there are presented the short description and methods of diagnostics of the endemic diseases. Diagnostic search of the reasons of the protracted subfebrile fever in children surely should come to an end with the diagnosis, which is present in the international classification of diseases of the X revision.
New aspects of the mechanisms of development and treatment of irritable bowel syndrome
Authors: Tipikina Mariya Yuryevna , Korniyenko Yelena Aleksandrovna
Published: February 2016

In 121 children with irritable bowel syndrome (IBS) a complex evaluation of the values of volum threshold sensitivity (VTS) of the rectum, intestinal microbiota according to the findings of feces analysis and lactulose hydrogen test, and also of the activation of inflammation according to endoscopy, histology, stool calprotectin testing and proinflammatory cytokines in the colonic mucosa was performed. The estimation of these parameters before and after treatment with probiotics, trimebutin, combination therapy of pro-and prebiotics, combination therapy trimebutin and probiotics for 1 month. The control group were children receiving placebo. In all patients with IBS enhanced VTS was noted. Signs of inflammation were detected according to the findings of endoscopy in 66.9 %, of histology – in 97.5 %, enhanced levels of calprotectin were found in 27.3 %, enhanced levels of IL-8 — 45 at %, INF-γ — 90 %. In all patients with IBS have disbiotic disorders of the colon, sings of bacterial overgrowth syndrome were detected in 85.1 % of children. Probiotics effective in reducing the VTS, improving of clinical data,microbiological indices, and coping with of inflammatory disorders in the intestines. Are the most effective of treatment with both trimebutin and probiotics, or probiotics and prebiotic lasting at least one month.
Current conception of the link of obesity and intestinal microbiota
Authors: Korniyenko Yelena Aleksandrovna
Published: February 2016

More than 500 million people in the world are overweight, this “epidemic” covers all countries, including Russia, and there is both in adults and in children. This is usually attributed to a change in lifestyle and diet of modern people, that also may influence at intestinal microbiota. Microbiota takes part in the energy and fat metabolism, which has been proven in germ-free animals. Transplantation of microflora from overweight animals to germ-free ones contributed to the development of obesity, regardless of diet. Obesity is accompanied by mild chronic inflammation, it can be a result of changing of intestinal microbiota. Lipopolysaccharides (LPS) of Gram (–) intestinal bacteria via activation of TLR-4 are the main cause of this inflammation. Intestinal microbiota of obese and slim is different. Obesity increases the number of Clostridia and Gram (–) Proteobacteria, reduced number of Bacteroides and Bifidobacteria. Recent works showed the positive influence of probiotics, particularly infant Bifidobacteria strains, on metabolic syndrome, in particular, the level of glucose, insulin, cholestero
Metabolic syndrome and morphofunctional state of pancreas in children: clinical and pathogenetic relationship
Authors: Bokova Tatyana Alekseyevna
Published: February 2016

The aim of the study: evaluation of pancreatic morphofunctional state of children with metabolic syndrome (MS). 48 children were examined with different shapes and degrees of obesity, ranging in age from 6 to 15 years old (23 males and 25 females). 2 selected groups: core group-31 child with MS, the comparison group-17 children with obesity without signs of MS. Decrease the postprandial response of the pancreas, which indicates lower adaptive capacity and high risk of development of chronic pancreatitis in children with MS. The interrelation between the overall size of the gland before and after food load with violations of carbohydrate and lipid metabolism. The results indicate the need for in-depth surveys of children with a view to the correction of excretory and endocrine functions of the pancreas decrease in risk of formation of MS
Mucopolysaccharidosis type I: genetic variants and enzyme replacement therapy experience in Saint-Petersburg
Authors: Buchinskaya Natalya Valeryevna , Kalashnikova Olga Valeryevna , Dubko Margarita Fedorovna , Kostik Mikhail Mikhaylovich , Chasnyk Vyacheslav Grigoryevich
Published: February 2016

In this article we describe a 5th years experience of enzyme replacement therapy (ERT) of mucopolysaccharidosis (MPS) type I, an autosomal recessive disease caused by deficienty of α-L- iduronidase. ERT by Aldurazyme (BioMarin, Genzyme, USA) used for patients with proved MPS I. The drug was intravenously administered in a dose 100 U/kg or 0,58 mg/kg per week. Also we evaluate the prevalence of genetic variants and first symptoms of the disease on a base of results of clinical examination and therapy children with MPS I in 2007—2012 years in 3rd pediatric department of State Pediatric Medical University. Composed recommendations for early diagnostic MPS I for specialists and parents
SOME ASPECTS OF THE MUKOAKTIV THERAPY OF ACUTE RESPIRATORY DISEASES IN THE CHILDREN
Authors: Soroka Natalya Dmitriyevna
Published: February 2016

The article presents the data on acute respiratory infections in children, defined the characteristics of the modern trends, gives a brief clinical characteristics of protracted variants of acute respiratory disease. The reasonability of mykoaktive therapy in the treatment of acute respiratory diseases. Presents data post marketing study of efficacy and safety of mykoaktive preparation Prospan (Manufacturer Engelhard Arzneimittel, Germany). Prospan marked by a high secretolytic, bronchospasmolytic effects and safety of dry extract of leaves of ivy of the treatment of acute respiratory diseases, including children of early age, as well as the opportunity to personalize the application of various medicinal forms preparation and ways of delivery to the organism of a sick child.
RESULTS OF EARLY SURGICAL TREATMENT OF OSTEOCHONDRITIS DISSECANS OF THE KNEE JOINT IN CHILDREN
Authors: Baindurashvili Alexey Georgievich , Sergeev Sergey Vladislavovich , Moskalenko Alexey Vitalievich , Pozdeeva Nina Anatolievna
Published: February 2016

The results of surgical treatment of osteochondritis dissecans (OCD) of a knee joint in children were studied. Three groups of monitoring were formed: arthroscopic treatment of early stages — 31 children, arthroscopic treatment of late stages — 14 children, arthrotomic treatment of late stages — 14 children. Immediate results are comparable in all the groups. The best long-term results were observed in groups of arthroscopic treatment, especially in early stages. Simultaneous application of bone marrow stimulation techniques and symptomatic treatment is more effective.
Diseases of a neurotic range at children with night enuresis
Authors: Chutko Leonid Semenovich , Surushkina Svetlana Yurievna , Nikishena Inna Sergeevna , Yakovenko Yelena Alexandrovna , Anisimova Tatyana Igorevna , Bykova Yulia Leonidovna
Published: February 2016

The article is devoted to the study of nocturnal enuresis and frequency of comorbid anxiety disorders in children with this disease. The authors present the results of a survey of 70 children aged 7 to 10 years with primary enuresis. In the study, anxiety disorders were found in 44 children with this pathology (62.9 %). Analysis of the identified symptoms showed that more of the study group are generalized anxiety disorder (31.8 %) and phobic anxiety disorder (40.9 %).
The differential diagnosis algorithms of hypertrophic cardiomyopathy and hypertrophic cardiomyopathy syndromes
Authors: Turalchuk Marina Vitalyevna , Novik Gennadiy Ayzikovich , Goodkova Aleksandra Yakovlevna
Published: February 2016

The differential diagnosis in HCM patients is discussed. Literature data and results of 98 hypertrophic cardiomyopathy patients examination are given. The differential diagnosis algorithms for HCM and HCM syndromes are proposed.
The results of using automated system of prophylactic examination of children in Yakutsk
Authors: Yevseyeva Sardana Anatolevna , Dranaeva Galina Gavrilovna , Kontorusova Svetlana Vasilievna , Chasnykh Vyacheslav Grigoryevich , Burtseva Tatyana Egorovna , Shadrin Victor Pavlovich , Avrusin Sergey Lvovich
Published: February 2016

In this article the results of introduction of technology AKDO are presented to out-patient and policlinic service and possibilities of optimum use of this technology in school and preschool offices, in an office of the school doctor are offered.
Specials clinical symptoms the local and general forms of surgical infection of soft tissues on the children’s age
Authors: Barhatova Natalia Anatolievna
Published: February 2016

In article include results of analyses specials clinical and laboratories manifestations the local and general forms of infection on the soft tissues at the children in different age. Were revealed the most significant factors of risk development general form of infection in the children´s age. Also were determined clinical specials of systemic inflammatory response syndrome in dependent of the character inflammatory reaction of soft tissues, time of hospitalization and time of surgical intervention. Were revealed the most typical combinations symptoms of systemic inflammatory response syndrome on the child in different age. It´s allow improve early clinical diagnostic of sepsis on the child and shorten time of start equivalent therapy of general forms of infection.
The role and place of modern educational technologies in medical school
Authors: Levanovitch Vladimir Viktorovich , Suslova Galina Anatol’evna , Gostimsky Alexander Vadimovich
Published: February 2016

This article reviews aspects of the organization of the educational process in medical school using advanced simulation technologies. It contains a brief historical background of the origin and development of simulation technologies.The necessity of introducing simulation in graduate and post-graduate training of students and doctors is justified. The problems of modern medical education and methods of their solutions with the phantom simulation classes are described.The aspects of the optimal organization of phantom simulation classes and learning process, based on the experience of the Center of Modern Educational Technologies in Saint-Peterburg State Pediatric Medical University are addressed.It presents modern concepts and methods of new educational technologies in the educational process.
Nonalcoholic fatty liver disease in childhood
Authors: Kornienko Elena Aleksandrovna , Vlasov Nikolai Nikolayevich , Chistyakova Alexandra Vladimirovna
Published: February 2016

In recent years the non-alcoholic fatty liver disease (NAFLD) has become one of the most common liver disease in children and adolescents. This phenomenon is explained by the sharp rise in obesity among the population worldwide, including children, and increased co-morbidities associated with obesity. There is sufficient evidence that age and gender are important determinants of the risk for the development of fatty liver disease in children. There is reason to believe that an important role in the pathogenesis of NAFLD in children may play a hormonal profile in adolescents, family history, the state of insulin sensitivity and the level of adipocytokines. However, these studies are still limited to a small number of observations. Liver biopsy remains the standard for the diagnosis and staging of NAFLD. At the same time, children in some cases observed morphological pattern, which is not typical for adults. There is a need for the development of alternative non-invasive methods of diagnosis of NAFLD and imaging of hepatic steatosis . Clinically, the disease occurs in children is diverse and can be malignant, but the natural history and prognosis are still to be determined. Also the necessary lifestyle changes in NAFLD in children are not determined reliably, and a multi-center randomized clinical trials on the drug therapy are not compleated.
Autoimmune gastritis in children with autoimmune diseases
Authors: Zvyagin Aleksandr Alekseyevich
Published: February 2016

The results of inspection of 70 children for autoimmune gastritis are represented. Children with blood serum antibodies to stomach parietal cells were selected for more profound investigation. It was shown, that autoimmune gastritis in the childhood is one of the components of multiorgan autoimmune pathology in 0-33 % of patients and is characterized by minimum clinical, morphological and endoscopic data, combination with Helicobacter pylori.
Regional Features of Saint-Petersburg Schoolchildren Level of Health
Authors: Zemlyanoy Dmitry Alexeevich , L’vov Sergey Nikolaevich
Published: February 2016

The article presents the results of the study of three grades schoolchildren health level. The authors have revealed that the percentage of children of the 1st health group does not exceed 13 %. It has been determined that educational process intensification does not take into account the features of modern schoolchildren health status. Reliable growth of children of the 2nd and 3rd health groups (in dynamics of health indicators over the training period) including ophthalmic, musculoskeletal and nervous systems disorders has been detected. According to the analysis of the database, coming generation health protection is one of priority directions among educational and medical institutions activities.
Surgical treatment of diffuse toxic goiter in children. A review of the literature
Authors: Gostimsky Alexander Vadimovich , Peredereev Sergey Sergeevich
Published: February 2016

Diffuse toxic goiter (DTG) is an autoimmune disease, to which there is a genetic predisposition. In children DTG is less common than in adults. Manifestation of graves‘ disease in childhood has a number of peculiarities. During the DTG in children is usually manifested thyrotoxicosis, requiring long-term treatment to achieve euthyroid, tendency to relapse and more frequently than adults, accompanied by ophthalmopathy and the large size of goiter. Diagnosis of graves‘ disease is based on the clinical picture of thyrotoxicosis, the existence of which is confirmed by the level of thyroid hormones and TSH in the blood. There are three types of treatment of patients DTG: medical, radioactive iodine therapy and surgery. There is no а single glance at the choice of the volume of operations in children.
The history of recurrent laryngeal nerve research
Authors: Vabalayte Kristina Victorovna , Romanchishen Anatoly Philippovich
Published: February 2016

A. Burns described thyroid cancer in 1811. History of surgical treatment of thyroid cancer is presented in the article. N. I. Pirogov was the first in the world who performed thyroid resection under general anesthesia in 1847. A. A. Bobrov was the first who started to perform thyroid operations under recurrent nerves visual control since 1893. V. I. Razumovsky was the first who described anaplastic and medullary thyroid carcinomas in 1903. Tactics in thyroid cancer treatment in different country are presented.
The attitude to children, their right for life and development in Russia (X cent.-beginning of the XVIII cent.)
Authors: Mikirtichan Galina Lvovna
Published: February 2016

The article discusses the problem of treatment of children and care for them during the period of Kiev and Moscow Rus and Russia at the beginning of the XVIII century. The basic legislative acts and documents reflecting the situation with children and their legal status, relationships between parents and children are analyzed. The basic principle of relations within the family was lawlessness, unquestioning obedience children to parents which was maintained by both oral reprimands and corporal punishment. Peter I had a systematic program of little-year-olds’ charity on the state level. A number of his decrees aimed to stop infanticide , to change the system of orphans’ protection and help, to alleviate the fate of illegitimate children (including the organization of hospitals for “bastards” and wet nurses service), to create conditions for upbringing and education of children, to reduce beggary. Speed, pragmatism, brutal methods of his reforms splitted the Russian society which was not ready for the new, including the state regulation of orphans’ charity, so the fulfillment of his decrees met great difficulties.
Physiological Scientific Pedagogical Schools of the Leningrad Pediatric Medical Institute - Saint Petersburg State Pediatric Medical University
Authors: Lytayev Sergey Aleksandrovich
Published: February 2016

This paper is presented to leading representatives of physiological schools of pediatric medical institute since 1925 to present time. Achievements in the field of physiology are connected with such remarkable names, as M. S. Maslov, A. F. Tur, A. G. Ginetsinsky, D. G. Kvasov, V. D. Glebovsky, J. P. Pushkarev, etc. The article opens the contribution of scientists to development of a physiological science at Russia and abroad, and also a role of physiologists in preparation of physicians-pediatrists.
Analysis of Independent Components for ERPs from ADHD patients of various ages
Authors: Pronina Marina Vladimirovna , Ponomarev Valeriy Aleksandrovich , Müller Andreas , Kropotov Yuriy Dmitriyevich
Published: February 2016

We investigated the characteristics of independent components for event-related potentials in adolescents (11- 17 years old) and adults (18-30 years old) with attention deficit hyperactivity disorder (ADHD), compared to the normative database. In both age groups was found significant decrease in the amplitude of the two independent components generated (according to sLORETA) in the left posterior temporal and premotor cortex and presumably associated with the processing of visual stimuli and the action suppression. In the teenage group, moreover, was broken component generated in the cingulate cortex in the adult group - another component, the source of which is localized in the premotor cortex.
Particular Features of the Sonograms of the Ligamentum Arteriosum and Para-Aortic Arterial Calcifications in Children Suffering From Tuberculosis of Intrathoracic Lymph Nodes
Authors: Sinitsyna Anastasiya Vyacheslavovna , Sinelnikova Yelena Vladimirovna , Krivokhizh Valentin Nikolayevich , Krasnogorskaya Olga Leonidovna , Nasyrov Ruslan Abdullayevich , Gavrilov Pavel Vladimirovich , Zharov Yevgeniy Viktorovich
Published: February 2016

The paper presents the results of a study aimed to check the assumption that there is disparity in interpretation of X-ray and ultrasound images of Ductus arteriosus in children supposed to have tuberculosis. In total the images of 230 children with ambiguous Mantoux tuberculin skin test and with calcification adjusted to aortic window described in terms of regular X-ray were investigated. It is stated that multispiral computer tomograms are usually falsely interpreted as presenting calcifications in cases when ultrasound scans reveal only tissue heterogeneity near former Ductus arteriousus.
The systemic arterial pressure waveform management by means of the study of peripheral vessels
Authors: Pugovkin Andrey Petrovich , Verlov Nikolay Aleksandrovich , Landa Sergey Borisovich , Yerkudov Valeriy Olegovich
Published: February 2016

The systemic arterial pressure waveform was reconstructed from peripheral pulse curve measured dy volume-clump method with sphygmoarteriorhythmograph SACR-2 by means of specially designed transfer function. The restored pulse curve was compared with that obtained from peripheral pulse curve measured with appliqué gauge and software of the Sphygmocor cardiovascular system. The comparative study revealed the identity of results obtained via both approache.
Prenatal effects of buspirone and stress on behavioral reactions in rat pups of different sexes during period of ontogeny with low level of brain serotonin
Authors: Butkevich Irina Pavlovna , Shimarayeva Tatyana Nikolayevna , Mikhaylenko Viktor Anatolyevich
Published: February 2016

Previously we revealed for the first time pain response exacerbation caused by inflammation in rats born to dams exposed to stress during pregnancy (prenatal stress). The present study is devoted to tinvestigation of prenatal stress effects on psychoemotional and tonic pain reactions in rat pups during the individual development period that is characterized with a dramatic reduction of the brain serotonin level. Effects of maternal buspirone before stress during pregnancy on functional indices of psychoemotional and tonic pain systems in the offspring were also investigated. Prenatal stress increased the number of pain patterns (flexing + shaking) during different phases of the time-course of formalin-induced pain in females and males to a greater extent in males. Prenatlly stressed rat pups of both sexes failed to show reliable changes in the index of psychoemotional behavior in the forced swim test. With the aim to decrease pain response exacerbation found in prenatally stressed offspring, pregnant dams were exposed to chronic injections of serotoninergic anxiolytic and antidepressant buspirone which is an agonist of 5-HT1A receptors; prenatal effect of buspirone on psychoemotional behavior in prenatally stressed rat pups was also evaluated. Maternal buspirone normalized pain behavior and decreased considerably the time of immobility, the index of depressive behavior in the forced swim test. The present results indicate analgesic and antidepressive effects of maternal buspirone in prenatally stressed 10-day old rat pups and demonstrate sexual dimorphism in effects of prenatal stress on the time-course of formalin-induced pain. Differences in effects of prenatal influences on pain respone during the interphase in males and females indicate earlier maturation of the descending serotonergic inhibitory system of afferent pain signals modulation in males than in females and demonstrate that 5-HT1A receptors are involved in this process.
Adaptive capabilities under extreme conditions, depending on motivational orientation of Anesthesiologist
Authors: Ironosov Vaycheslav Yevgen’evich , Lytayev Sergey Aleksandrovich , Gordeev Vladimir Ilich
Published: February 2016

The aim is to identify the level of adaptive capacity anesthesiologists depending on the motivational orientation. Presented survey data 149 anesthesiologists. Testing was conducted on a multi-level personality questionnaire «Adaptability» and on the test Kuhl. The results showed that most physicians have high adaptive capacity, which is highly correlated with the motivational oriented under extreme conditions. The necessity of developing a program of psychological support to the development of non-motivational deficit.
Formation and development of Berck-sur-mer children resort in the 2nd half of the 19th and in the beginning of the 20th century
Authors: Ponomareva-Soenen Elena Vladimirovna
Published: February 2016

The article presents a review of a former fishing village in the north of France, which became a national climatic resort that influenced a lot the sanatorium movement in Russia; it also portrays doctors and other leaders that played the crucial part in this process; a variety of factors with the following historic and medical analysis is given. Both climatic factors and the social background of the changes in the infrastructure that took place in the 2nd half of the 19th and in the beginning of the 20th century are appraised.
Genetic markers of celiac disease: modern concern
Authors: Zakharova Irina Nikolayevna , Borovik Tatyana Eduardovna , Roslavtseva Yelena Aleksandrovna , Kasatkina Yelena Nikolayevna , Dmitriyeva Yuliya Andreyevna
Published: February 2016

According to the results of recent scientific studies there is a strong evidence to characterize celiac disease as genetic disorder associated with antigens of major histocompatibility complex (MCH II) HLA-DQ2 and HLA-DQ8. Different loci of HLA molecules are encoded by specific alleles and their combination determines the individual risk of celiac disease formation. In this article authors discuss data on structure of DQ2 and DQ8 molecules, the frequency of different alleles detection in celiac patients and possible classification of genetic risk of celiac disease formation according to HLA-DQ genotype.
At the origins of Saint-Petersburg state pediatric medical university: the contribution by an outstanding pediatrician K. A. Rauchfuss
Authors: Levanovich Vladimir Viktorovich , Mikirtichan Galina Lvovna , Savina Irina Aleksandrovna
Published: February 2016

Based on archival and published materials, the article describes the activity of an outstanding pediatrician and one of the founders of pediatrics in Russia K. A. Rauchfuss (1835-1915). His contribution to clinical pediatrics, training of pediatricians and the development of new children’s hospitals with regard to the age-related pathology, as well as the style of his management and principles of building relationship with colleagues, patients and their relatives is consi-dered. The role of K. A. Rauchfuss in the organization of the Children’s Hospital in Memory of Sacred Coronation of their Imperial Majesties (Saint-Petersburg, 1905) and his idea to open the Institute for the Protection of Motherhood and Infancy are highlighted. At present, the Saint-Petersburg State Pediatric Medical University is taking steps to commemorate the name of K. A. Rauchfuss, particularly to restore the memorial plaque that was put on the wall of one of the pavilions in 1909.
Features of surgical treatment of nasolacrimal duct stenoses in children
Authors: Brzheskiy Vladimir Vsevolodovich , Chistyakova Margarita Nikolayevna , Kalinina Irina Vyacheslavovna
Published: February 2016

42 children at age from 1 to 15 years (36 - with relapse of congenital nasolacrimal duct (NLD ) stenosis and 6 - with canalicular stenosis) bougienage NLD was done with Ritleng stent intubation. The control group included 25 children 1-5 years old with relapsed congenital stenosis of the NLD, the treatment of which was limited to probing the NLD. In the first group full functional effect was observed in 21 children (58.3 %), in 9 (25.0 %) - was light epiphoria, in 1 (2.8 %) - moderate, and in 5 (13.9 % ) treatment was not effective. In the second group a full functional effect was obtained for each child. In the control group lacrimal drainage was restored fully in 16 (64.0 %) children, in 2 (8.0 %) - moderate and in 7 (28.0 %) - severe epiphora was remained. Using of silicone intubation with the Ritleng lacrimal system allows to continuously retain their foramen in stenotic site without causing an inflammatory response and bedsores lacrimal punctum and canaliculus.
Methods of integrated diagnostics attention deficit hiperactivity disorderes (ADHD) in children
Authors: Fesenko Yuriy Anatolyevich , Fesenko Yelena Vladimirovna
Published: February 2016

It was proved by cross-correlational analysis of EEG of the cohort children of 3-11 years with attention deficit/hyperactivity disorder (ADHD), called minimal brain dysfunction (MDM). On the basis of comprehensive diagnostics, including - for the cross-correlation analysis of EEG computer (QEEG) in normal and ADHD construct therapeutic tactics in the treatment of children with this syndrome. Using QEEG data, the authors confirm the violations of interaction between structures of the cerebral cortex with ADHD compared to the norm, especially between the frontal and parietal-occipital region, as well as between the right parietal-occipital region with all the other departments of the cortex.
The possibility of the conscious decreasing in heaviness of the bradyenteria in medical students
Authors: Yurov Andrey Yuryevich , Shemerovskii Konstantin Aleksandrovich
Published: February 2016

The possibility in principle of the conscious psychophysiological decreasing of the circadian rhythm disorders was researched in the example of intestinal tract evacuation function. The investigation was fulfilled in medical students by the way of additional informing them about chronophysiological regularity importance of defecation rhythm. It is shown that getting them this information promotes three basic effects: increasing the frequency of morning defecation rhythm; diminution the risk of the bradyenteria heavy-stage occurrence due increased probability of its modifying into more easy stages; significant elevation of the sleeping gratification.
CNS defeat in early congenital syphilis
Authors: Melashenko Tamara Vladimirovna , Milyavskaya Irina Romanovna , Gorlanov Igor Aleksandrovich , Leina Larisa Mikhaylovna
Published: February 2016

Early congenital syphilis, in 60 % of cases, accompanied by a specific lesion of the central nervous system. Clinical manifestations of neurosyphilis in newborns are usually absent. Diagnosis is based on serological examination of cerebrospinal fluid and MRI. The paper presents two cases of early syphilis with central nervous system.
Individual and group peculiarities of adaptation in ontogeny (review and problem statement)
Authors: Khaitsev Nikolai Valentinovich , Vasiliev Andrey Glebovich , Trashkov Aleksandr Petrovich
Published: February 2016

А complex of biochemical, hematologic and physiologic parameters determine individual variability that should correlate with general resistance of the organism. Hypoxia, a universal pathologic process is recommended as a model for studying individual adaptation in ontogeny. Hypophysis-adrenals system (HAS) activity may produce decisive effect upon the organism’s response reactions’ trend. HAS activity changes with age. Parallel to these changes resistance to hypoxia also alters. This process is gender-dependant. Individual and group peculiarities of resistance to acute hypoxia at various ontogenic periods should be compared to HAS functional state at respective periods separately for males and females. These correlations would facilitate better understanding of resistance variability general mechanisms characteristic of individual and group levels.
Infections in mother, fetus and newborn infant
Authors: Savicheva Alevtina Mikhailovna
Published: February 2016

The article reviews some major problems of diagnosis, prophylaxis and treatment of infections in mother, fetus and newborn infant and discusses possible ways of solving them. It is emphasized that there is a need in standardized approaches to management of pregnant women with infections imposing a risk of adverse effects on fetus or newborn infant, which can be achieved by development and implementation of national guidelines on management of perinatal infections.
Gastrointestinal microflora of full-term newborn infants with different modes of delivery
Authors: Rybina Yelena Vladimirovna , Kenbayeva Kamila Gabitovna , Savicheva Alevtina Mikhailovna
Published: February 2016

The study aimed to investigate the microflora of the gastrointestinal tract in infants born via vaginal delivery or Cesarean section. In the first hours postpartum, microbial colonization of the gastrointestinal tract occurred in 78 % of the infants born via vaginal delivery, and in 27 % of the infants born via Cesarean section. The effects of antibiotics and probiotics, which were administered to the women during pregnancy and labor, on the composition of gastrointestinal micro-flora in infants were studied. In the infants born to mothers receiving antimicrobials lactobacilli in gastric aspirate and meconium were not detected. Using probiotics during pregnancy did not have any effect on lactobacilli detection in the infants.
Application of quantitative multiplex real-time polymerase chain reaction for identification of causative agents of urinary tract infections in pregnancy
Authors: Khusnutdinova Tatyana Alekseyevna , Savochkina Yuliya Anatolyevna , Gushchin Aleksandr Yevgenyevich , Shipitsyna Yelena Vasilyevna , Savicheva Alevtina Mikhailovna
Published: February 2016

Urinary tract infections (UTIs) represent the most common bacterial infections and often complicate pregnancy. UTIs in pregnancy are classified by site of bacterial proliferation as follows: asymptomatic bacteriuria, cystitis, pyelonephritis. Screening for asymptomatic bacteriuria is a standard of obstetrical care and is included in most international guidelines. The urine microbiologic culture is considered the gold standard for laboratory diagnosis of UTIs. Molecular methods enable to rapidly detect, identify and quantitate causative agents of UTIs in urine and are effective alternative to traditional bacteriological methods.
Morphological facial features of people with the reduced height of the gnathic part of the face
Authors: Fishchev Sergey Borisovich , Sevastyanov Arkadiy Vladimirovich , Orlova Irina Viktorovna
Published: February 2016

The work contains the characteristics of the morphological facial features of people with reduced height of the gnathic part of the face. The work shows the morphological features of the gnathic part of the face depending on the form of its lowering - dentoalveolar, gnathic, or complex. The obtained data can be used to define the approach for both the orthodontic and prosthetic care of patients who suffer from the tooth alignment defects combining with occlusion anomalies.
Experience Reduce TB in children with routine immunization in Republic of Belarus
Authors: Shmeleva Natalya Dmitriyevna , Turpakova Tatyana Genadyevna
Published: February 2016

General characteristic of the epidemic process in Tuberculosis in the Republic of Belarus for the period 1997 to 2013. Relative incidence active Tuberculosis of the total population compared with similar mental data registered in children aged 0-17 years. The tendency of morbidity compared modified as common approaches to immunization against tuberculosis of those observed in the study period. The article also provides an analysis of mass tuberculin, conducted routinely in children during the study time frame.