bluuebunny/crossref_metadata_2025 huggingface dataset:
A Comparative Study of Proteolytic Mechanisms during Leaf Senescence of Four Genotypes of Winter Oilseed Rape Highlighted Relevant Physiological and Molecular Traits for NRE Improvement
Authors: Girondé Alexandra , Poret Marine , Etienne Philippe , Trouverie Jacques , Bouchereau Alain , Le Cahérec Françoise , Leport Laurent , Niogret Marie-Françoise , Avice Jean-Christophe
Published: December 2015

Winter oilseed rape is characterized by a low N use efficiency related to a weak leaf N remobilization efficiency (NRE) at vegetative stages. By investigating the natural genotypic variability of leaf NRE, our goal was to characterize the relevant physiological traits and the main protease classes associated with an efficient proteolysis and high leaf NRE in response to ample or restricted nitrate supply. The degradation rate of soluble proteins and D1 protein (a thylakoid-bound protein) were correlated to N remobilization, except for the genotype Samouraï which showed a low NRE despite high levels of proteolysis. Under restricted nitrate conditions, high levels of soluble protein degradation were associated with serine, cysteine and aspartic proteases at acidic pH. Low leaf NRE was related to a weak proteolysis of both soluble and thylakoid-bound proteins. The results obtained on the genotype Samouraï suggest that the timing between the onset of proteolysis and abscission could be a determinant. The specific involvement of acidic proteases suggests that autophagy and/or senescence-associated vacuoles are implicated in N remobilization under low N conditions. The data revealed that the rate of D1 degradation could be a relevant indicator of leaf NRE and might be used as a tool for plant breeding.
Exploring Heterogeneous Preference for Farmland Non-market Values in Wuhan, Central China
Authors: Yang Xin , Burton Michael , Cai Yinying , Zhang Anlu
Published: December 2015

The research question for this study is estimating the public’s willingness to pay for the public goods generated by farmland, and exploring respondents’ heterogeneity in their preferences for these goods. The approach used is a choice experiment, using respondents from the city of Wuhan, China. Six attributes representing public good values (farmland area, farmland fertility, water quality, air quality, species richness, and recreational value) and the level of private cost are selected in this study. A heteroscedastic conditional logit model is used to analyze the respondents’ willingness to pay for improvements in these public goods, accounting for systematic heterogeneity in public preferences. The results show the public are willing to pay to preserve the non-market values generated by farmland, with air quality valued most and followed by farmland fertility, farmland area, water quality, species richness and recreational value. In addition, respondents with higher income, and who are aware of the non-market values of farmland and have a willingness to pay for it have a smaller error variance, i.e., these respondents are more consistent in their choices. This study may help decision makers improving more differentiated farmland protection policies.
The Evolution of River–Lake and Urban Compound Systems: A Case Study in Wuhan, China
Authors: Wang Wei , Pilgrim Melissa , Liu Jinan
Published: December 2015

The process of urbanization takes up a lot of wetlands, profoundly changing the natural connection of surrounding river–lake systems, all the while causing serious damage to the environment of connected catchments. Urban systems and river–lake systems are not isolated and static, there is a relation between them which is constantly changing. Based on the idea of system research, the urban system is simplified into four subsystems: environment, infrastructure, social, and economic. These four components interact together, influencing the river–lake system to form a compound system. This paper aims to reflect the features and evolution laws of the compound system, by building a Collaborative Development Model to study the changing of the compound system in Wuhan, China over a 10-year period. The results show that by implementing the Donghu Lake Ecological River Network Engineering Project, the damaged river–lake system in Wuhan showed some improvement. However, in order to improve the sustainability of the compound system in Wuhan, the status of the river–lake system, social system and environment system, which are still comparatively substandard, should be constantly improved. The Collaborative Development Model could also be used in other cities and regions, to provide the basis for sustainable development.
Anthrax Susceptibility: Human Genetic Polymorphisms Modulating ANTXR2 Expression
Authors: Zhang Zhang , Zhang Yan , Shi Minglei , Ye Bingyu , Shen Wenlong , Li Ping , Xing Lingyue , Zhang Xiaopeng , Hou Lihua , Xu Junjie , Zhao Zhihu , Chen Wei
Published: December 2015

Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax toxin receptor 2) are strongly correlated with anthrax toxin susceptibility. Previous studies found that ANTXR2 transcript abundance varies considerably in individuals of different ethnic/geographical groups, but no eQTLs (expression quantitative trait loci) have been identified. By using 3C (chromatin conformation capture), CRISPR-mediated genomic deletion and dual-luciferase reporter assay, gene loci containing cis-regulatory elements of ANTXR2 were localized. Two SNPs (single nucleotide polymorphism) at the conserved CREB-binding motif, rs13140055 and rs80314910 in the promoter region of the gene, modulating ANTXR2 promoter activity were identified. Combining these two regulatory SNPs with a previously reported SNP, rs12647691, for the first time, a statistically significant correlation between human genetic variations and anthrax toxin sensitivity was observed. These findings further our understanding of human variability in ANTXR2 expression and anthrax toxin susceptibility.
Newcastle Disease Virus: Potential Therapeutic Application for Human and Canine Lymphoma
Authors: Sánchez Diana , Pelayo Rosana , Medina Luis , Vadillo Eduardo , Sánchez Rogelio , Núñez Luis , Cesarman-Maus Gabriela , Sarmiento-Silva Rosa
Published: December 2015

Research on oncolytic viruses has mostly been directed towards the treatment of solid tumors, which has yielded limited information regarding their activity in hematological cancer. It has also been directed towards the treatment of humans, yet veterinary medicine may also benefit. Several strains of the Newcastle disease virus (NDV) have been used as oncolytics in vitro and in a number of in vivo experiments. We studied the cytolytic effect of NDV-MLS, a low virulence attenuated lentogenic strain, on a human large B-cell lymphoma cell line (SU-DHL-4), as well as on primary canine-derived B-cell lymphoma cells, and compared them to healthy peripheral blood mononuclear cells (PBMC) from both humans and dogs. NDV-MLS reduced cell survival in both human (42% ± 5%) and dog (34% ± 12%) lymphoma cells as compared to untreated controls. No significant effect on PBMC was seen. Cell death involved apoptosis as documented by flow-cytometry. NDV-MLS infections of malignant lymphoma tumors in vivo in dogs were confirmed by electron microscopy. Early (24 h) biodistribution of intravenous injection of 1 × 1012 TCID50 (tissue culture infective dose) in a dog with T-cell lymphoma showed viral localization only in the kidney, the salivary gland, the lung and the stomach by immunohistochemistry and/or endpoint PCR. We conclude that NDV-MLS may be a promising agent for the treatment of lymphomas. Future research is needed to elucidate the optimal therapeutic regimen and establish appropriate biosafety measures.
Exploring the Determinants of e-Commerce by Integrating a Technology–Organization–Environment Framework and an Expectation–Confirmation Model
Authors: Song Sung Mi , Kim Eojina , Tang Rebecca (Liang) , Bosselman Robert
Published: December 2015

An increasing number of lodging businesses utilize online third-party intermediaries (OTPIs) for distribution services on the internet. The purpose of the study was to investigate the decision-making processes of lodging firms in the adoption of OTPIs. The study developed and tested
a conceptual model by strategically combining a technology–organization–environment framework (TOE) and an expectation–confirmation model (ECM). The results showed that, with regard to TOE, technology and organization have significant impacts on confirmation in ECM. Furthermore,
the environment aspect of TOE significantly influences satisfaction in ECM, and both confirmation and satisfaction are antecedents of continuance intention. The study contributes to the knowledge body of TOE and ECM, and provides industry practitioners with strategies for the communications
and decision-making processes of lodging businesses and OTPIs.
Prospects and Challenges in the Study of New Age Tourism: A Critical Commentary
Authors: Pernecky Tomas , Poulston Jill
Published: December 2015

The New Age phenomenon is a marginal unknown in tourism studies, despite its inclusion under the broader umbrella of religious tourism, and various attempts to conceptualize it as a form of New Age tourism. It offers an opportunity for researchers in the field to study a large part
of a society that is neither separate from, nor necessarily included in, categories of religion. In this review article, Pernecky and Poulston challenge typical tourism approaches to segmenting markets into discrete groups, and work with the premise that if approached through an understanding
of social, cultural, political, and spiritual contexts, New Age is a fertile capping term for a phenomenon that shapes the global mind change, shifting values, understandings, and behaviors in the world. To address broader concerns, the authors provide both a critical review of existing definitions
and conceptualizations of the New Age phenomenon and an historical foundation for both the phenomenon and the term. Pernecky and Poulston also highlight potential pitfalls in the study of the New Age concept, and present a complex set of challenges for tourism researchers, students, and practitioners
who may be tempted by etic framings of the subject. In that light, the authors emphasize the need for emic approaches, that is, those which painstakingly and demonstrably acknowledge the perspectives, viewpoints, and experiences of the actors involved, which they argue are more
richly suited for understanding “New Agers.” Importantly, the review article presents the New Age movement and concept not only as a singular “special interest group,” but as a context of noteworthy conceptual value, as touristic objects, places, and experiences indeed
play a vital role in the constitution of meaning and interpretation—that is, in the worldmaking processes of our time. (Abstract by Reviews Editor)
The Gut in Older Patients on Peritoneal Dialysis
Authors: Setyapranata Stella , Holt Stephen G.
Published: December 2015

Age-related changes in gastrointestinal symptoms need to be considered in peritoneal dialysis (PD) patients. A diminishing appetite is associated with aging and may be exacerbated by renal failure and PD treatment, meaning that attention to dietary adequacy is important in the older patient. Constipation and its treatment may increase the risk of peritonitis, but is important for comfort as well as trouble-free dialysis. Diverticulosis increases with age, and whilst there may be ethnic differences in the patterns of this condition, there is conflicting evidence regarding the risks of peritonitis associated with asymptomatic disease. Hernias, urinary incontinence, and prolapse are also common and made worse by PD, so it is important to know about these issues prior to starting. Whilst data around these topics are scant and some studies conflicting, further understanding these issues and considering mitigation strategies may improve technique survival and quality of life.
Geriatric Assessment, Falls and Rehabilitation in Patients Starting or Established on Peritoneal Dialysis
Authors: Jassal Sarbjit Vanita
Published: December 2015

Individuals aged over 70 years at the time of starting dialysis have a varied and often challenging existence on dialysis. Canadian data suggest those starting dialysis between the ages of 75 and 79 years will have an average life expectancy of 3.2 years, while based on US data, patients can expect an average life expectancy of 25 months. A substantial proportion of these patients will, however, experience transient or permanent loss of personal independence within the first few months to years on dialysis. Preliminary data from patients recently started on peritoneal dialysis (PD) suggest patients and families adapt, but that the adaptation often involves limiting activities and altering the social role the patient has within the family. As data emerge, it will be possible to hypothesize whether this adaptation is beneficial in the long term, or whether these adaptations are permissive, allowing the patient to play a sick role leading to an accelerated transition to frailty and possibly death. Future research will hopefully inform us whether the functional dependency can be identified early and whether it is preventable. In the interim, repair rather than prevention is possible through rehabilitation. We therefore advocate that programs providing PD care consider the integration of protocols whereby patients may undergo formal evaluation to identify those who would benefit from walking or personal care aids, rehabilitation interventions, and, when needed, personal support.
THE ELLIPTICITY DISTRIBUTION OF AMBIGUOUSLY BLENDED OBJECTS
Authors: Dawson William A. , Schneider Michael D. , Tyson J. Anthony , Jee M. James
Published: December 2015

Using overlapping fields with space-based Hubble Space Telescope and ground-based Subaru Telescope imaging we identify a population of blended galaxies that are blended to such a large degree that they are detected as single objects in the ground-based monochromatic imaging, which we label “ambiguous blends.” For deep imaging data, such as the depth targeted with the Large Synoptic Survey Telescope (LSST), the ambiguous blend population is both large (∼14%) and has a distribution of ellipticities that is different from that of unblended objects in a way that will likely be important for weak lensing measurements. Most notably, for a limiting magnitude of i ∼ 27 we find that ambiguous blending results in a ∼14% increase in shear noise (or an ∼12% decrease in the effective projected number density of lensed galaxies; n
eff) due to (1) larger intrinsic ellipticity dispersion, and (2) a scaling with the galaxy number density N
gal that is shallower than

For the LSST Gold Sample (i < 25.3) there is a ∼7% increase in shear noise (or ∼7% decrease in n
eff). More importantly than these increases in the shear noise, we find that the ellipticity distribution of ambiguous blends has an rms that is 13% larger than that of non-blended galaxies. Given the need of future weak lensing surveys to constrain the ellipticity distribution of galaxies to better than a percent in order to mitigate cosmic shear multiplicative biases, if it is unaccounted for, the different ellipticity distribution of ambiguous blends could be a dominant systematic.
IGR J12580+0134: THE FIRST TIDAL DISRUPTION EVENT WITH AN OFF-BEAM RELATIVISTIC JET
Authors: Lei Wei-Hua , Yuan Qiang , Zhang Bing , Wang Daniel
Published: December 2015

Supermassive black holes (SMBHs) can capture and tidally disrupt stars or substellar objects orbiting nearby. The detections of Sw J1644+57-like events suggest that at least some TDEs can launch a relativistic jet beaming toward Earth. A natural expectation would be the existence of TDEs with a relativistic jet beaming away from Earth. The nearby TDE candidate IGR J12580+0134 provides new insights into the jet phenomenon. Combining several constraints, we find that the event invokes a 8−40 Jupiter mass object tidally disrupted by a

SMBH. Recently, a bright radio transient was discovered by Irwin et al. in association with IGR J12580+0134. We perform detailed modeling of the event based on a numerical jet model previously developed for the radio emission of Sw J1644+57. We find that the radio data of IGR J12580+0134 can be interpreted within an external forward shock model in the Newtonian regime. Using Sw J1644+57 as a template and properly correcting for its luminosity, we argue that the observed X-ray flux in early times is too faint to allow an on-beam relativistic jet unless the Lorentz factor is very small. Rather, the X-ray emission is likely from the disk or corona near the black hole. From various constraints, we find that the data are consistent with an off-beam relativistic jet with a viewing angle of

and an initial Lorentz factor of

a few. This scenario can readily be tested in the upcoming very long baseline interferometry observations.
Le sexuel infantile dans le rêve chez l’enfant et l’adulte
Authors: Gérard Christian
Published: December 2015

L’auteur reprend certaines interrogations des deux rapporteurs sur les traces et la transformation de la sexualité infantile retrouvées chez l’adulte. Il propose d’argumenter le débat avec deux éléments : « la mémoire du rêve élargie » incluant les éléments les plus précoces du vécu du sujet et l’apport du rêve chez l’enfant pour mieux entendre l’adulte en analyse.
La Peña Camasía (y sus diablos): ¿un lugar recuperado?
Authors: Simonatti Selena
Published: December 2015

El artículo estudia las ocurrencias y el significado del sintagma peña Camasía, íntimamente conectado con la expresión diablo de la peña (Camasía), y sus variaciones léxicas en algunos textos literarios del Siglo de Oro. Se examina el fenómeno de su difracción lingüistica y se explora el origen histórico-cultural de su implantación en el habla popular.
L’espace domestique au Bronze final et au premier âge du Fer dans le sud de la Corse
Authors: Peche-Quilichini Kewin , Delvaux Simon , Lachenal Thibault , Grevey Anne-Laure , Amici Simone , De Lanfranchi François , Bartoloni Gilda , Milletti Matteo , Bergerot Laurent , Mottolese Chiara , Biancifiori Elisa , Volpi Alessandro , Colomba Carraro Carmen
Published: December 2015

El objetivo de este artículo es ofrecer un acercamiento sintético a las formas de hábitat en Córcega entre el Bronce final (BF) y la primera Edad del Hierro (F1), a escala de la microrregión montañosa de la Alta Rocca, ubicada en el sur de Córcega en el corazón de la cuenca occidental del Mediterráneo. La problemática de estudio de los asentamientos protohistóricos sin fortificar es reciente en la isla, sin embargo, en los últimos años los estudios se han multiplicado y dan cuenta de la complejidad estructural y evolutiva de los espacios habitados, permitiendo así un primer análisis comparativo. El razonamiento se apoya esencialmente en la aportación de las excavaciones del gran hábitat de Cuciurpula, iniciadas en 2008 y todavía en curso, así como en la explotación de los poblados de Puzzonu y de Nuciaresa, sondeados en 2012. La cronología de los sectores estudiados permite abarcar un arco cronológico completo entre el siglo XII y el siglo VI a.C., y por tanto aprehender los fenómenos evolutivos, tanto en términos de organización general como a nivel del espacio interno y de la arquitectura de las viviendas.

[fr] L’objectif de cet article est de fournir une approche synthétique sur les formes de l’habitat en Corse au Bronze final (BF) et au premier âge du Fer (F1), à l’échelle de la microrégion montagneuse de l’Alta Rocca, située dans le sud de la Corse, au coeur du bassin occidental de la Méditerranée. La problématique d’étude des sites protohistoriques non fortifiés est jeune sur l’île, mais les travaux se sont récemment multipliés et rendent compte de la complexité structurelle et évolutive des espaces habités, permettant ainsi une premiére analyse comparative. Le raisonnement s’appuie essentiellement sur l’apport des fouilles du grand habitat de Cuciurpula, initiées en 2008 et toujours en cours, ainsi que sur l’exploitation des villages de Puzzonu et de Nuciaresa, sondés en 2012. La chronologie des secteurs étudiés permet d’embrasser un arc chronologique complet entre le XIIe et le VIe siécle av. J.-C., et donc d’appréhender les phénoménes évolutifs, tant en termes d’organisation générale qu’au niveau de l’espace interne et de l’architecture des habitations.
Gruta Nova da Columbeira (Bombarral, Portugal): un modelo de ocupación en cueva durante el Paleolítico Medio. Resultados del estudio del registro de macromamíferos
Authors: Fernández-Laso M. Cristina , Brugal Jean-Phillipe , Raposo Luis
Published: December 2015

Gruta Nova da Columbeira es uno de los conjuntos del Paleolítico medio más relevantes de la Estremadura Portuguesa y uno de los pocos yacimientos portugueses con restos de neandertal. En este trabajo se presentan los resultados del análisis zooarqueológico y tafonómico de los restos óseos de los macromamíferos recuperados en los niveles 6, 7, 8 y 9 de la excavación arqueológica llevada a cabo en 1962. Este estudio aporta información sobre el uso de la cavidad, el tipo de ocupación y las actividades desarrolladas en la misma. La cueva fue utilizada indistintamente por homínidos y carnívoros. Además, se han identificado otros agentes tafonómicos no antrópicos que han intervenido en la formación del registro óseo. Estos datos junto con los resultados de las dataciones aportadas por Zilhão y otros (2011) nos lleva a considerar que no es posible mantener que Gruta Nova sea uno de los últimos vestigios de la permanencia de los neandertales en el sur de la Península Ibérica, como se ha venido haciendo hasta ahora.
Primeras dataciones directas de 14C AMS para la orfebrería protohistórica del Noroeste de la Península Ibérica
Authors: Armada Xosé-Lois , García-Vuelta Óscar
Published: December 2015

En este artículo se dan a conocer las primeras dataciones radiocarbónicas directas para la orfebrería castreña del noroeste de la Península Ibérica, obtenidas a partir de tres muestras procedentes de una masa de fundición y de un lingote plano-convexo de los conocidos “tesoros” de Recouso (Oroso, A Coruña) y Calvos de Randín (Ourense). Los trabajos realizados han incluido el análisis mediante pFRX de las piezas de ambos conjuntos y la identificación de muestras de carbón, que permiten una mejor valoración de los resultados. Las dataciones apuntan a un momento avanzado de la II Edad del Hierro para ambos conjuntos y constituyen las primeras referencias cronológicas directas para esta rica tradición orfebre tras más de 100 años de investigación, abriendo una línea de trabajo que ofrece interesantes perspectivas de futuro.
Role of CrkII Signaling in RANKL-Induced Osteoclast Differentiation and Function
Authors: Kim Jung Ha , Kim Kabsun , Kim Inyoung , Seong Semun , Nam Kwang-Il , Lee Seoung Hoon , Kim Kyung Keun , Kim Nacksung
Published: December 2015

Rac1, a member of small GTPases, is a key regulator of osteoclast differentiation and function. The Crk family adaptor proteins, consisting of Src homology (SH) 2 and SH3 protein-binding domains, regulate cell proliferation, migration, and invasion through Rac1 activation. In this study, we examined the role of CrkII in osteoclast differentiation and function. Retroviral overexpression of CrkII in osteoclast precursors enhanced osteoclast differentiation and resorptive function through Rac1 activation. The knockdown of CrkII in osteoclast precursors using small interfering RNA inhibited osteoclast differentiation and its resorption activity. Unlike wild-type CrkII, overexpression of the three SH domains in mutant forms of CrkII did not enhance either osteoclast differentiation or function. Phosphorylation of p130 Crk-associated substrate (p130Cas) by osteoclastogenic cytokines in preosteoclasts increased the interaction between p130Cas and CrkII, which is known to be involved in Rac1 activation. Furthermore, transgenic mice overexpressing CrkII under control of a tartrate-resistant acid phosphatase promoter exhibited a low bone mass phenotype, associated with increased resorptive function of osteoclasts in vivo. Taken together, our data suggest that the p130Cas/CrkII/Rac1 signaling pathway plays an important role in osteoclast differentiation and function, both in vitro and in vivo.
Temperature Dependence of High Dielectric Strength Potting Materials for Medium Voltage Power Modules
Authors: O'Neal Chad B. , Feurtado Matthew , Stabach Jennifer , McNutt Ty , Passmore Brandon
Published: December 2015

Voltage insulation inside power modules is paramount for functional and reliable operation. Dielectric potting materials are stressed as the overall size of these modules is reduced due to size, weight, and cost considerations while the operating voltage of these modules continue to increase. In particular, voltage ratings of silicon carbide (SiC) device technologies will continue to increase above 6.5 kV into the tens of kilovolts in the future. SiC devices are also often operated at higher junction temperatures to take advantage of the high-temperature capabilities of the material. As the module temperature increases, the dielectric strength of insulating materials in the module tends to decrease, which is a serious concern for a compact power module operating at many kilovolts. A plurality of high-temperature-rated, high dielectric strength potting materials was tested for voltage breakdown and leakage current up to 30 kV and 250°C. A range of different materials, both conventional and novel, were tested, including silicones and Parylene. Materials were selected with a dielectric strength >20 kV/mm, an operating temperature range of 200°C or higher, and low hardness and modulus of elasticity with the intent of demonstrating the capability of blocking 20 kV or more in a reasonable thickness. A custom test setup was constructed to apply the voltage to test samples while measuring the breakdown voltage and simultaneously recording the leakage current. Test coupons were designed to provide a range of dielectric thicknesses over which to test the dielectric strength. Although voltage isolation may increase with increased dielectric thickness, the volt per millimeter isolation rate often decreases. The performance degradation of these materials over temperature is plotted, and insulation thicknesses are suggested for use with medium voltages at operating temperatures above 175°C.
Acute Acalculous Cholecystitis by Epstein-Barr virus Infection: A Rare Association
Authors: Branco Liliana , Vieira Maria , Couto Cristiana , Coelho Maria D. , Laranjeira Carla
Published: December 2015

Acute acalculous cholecystitis (AAC) is a rare complication of Epstein Barr virus (EBV) infection, with only a few cases reported among pediatric population. This clinical condition is frequently associated with a favorable outcome and, usually, a surgical intervention is not required. We report a 16-year-old girl who presented with AAC following primary EBV infection. The diagnosis of AAC was documented by clinical and ultrasonographic examination, whereas EBV infection was confirmed serologically. A conservative treatment was performed, with a careful monitoring and serial ultrasonographic examinations, which led to the clinical improvement of the patient. Pediatricians should be aware of the possible association between EBV and AAC, in order to offer the patients an appropriate management strategy.
Rhabdomyolysis induced by co-administration of fluvastatin and colchicine
Authors: Sarullo Filippo M. , Americo Luigi , Di Franco Antonino , Di Pasquale Pietro
Published: December 2015

A case of fluvastatin-induced rhabdomyolysis after coadministration of colchicine is reported. A 77 year old man with ischemic heart disease, chronic pericardial effusion, diabetes mellitus, dyslipidemia, arterial hypertension, chronic renal failure (stage 2 of classification of chronic kidney disease of National Kidney Foundation) and chronic gout presented with a generalized muscle pain. The patient had been taking 80 mg/day of fluvastatin for 4 years, and, for four weeks before presentation, he had also been taking a dose of colchicine (1.0 mg daily) for an exacerbation of gout. Investigations confirmed the diagnosis of rhabdomyolysis. Discontinuation of fluvastatin and colchicine therapy and adequate fluid administration resulted in the resolution of clinical and biochemical features of rhabdomyolysis. Although neuromuscular adverse effects of fluvastatin and colchicine are well recognized, rhabdomyolysis is rare, making this is only the second case reported of fluvastatin and colchicine co-administration induced rhabdomyolysis in literature.
Anabolic/Catabolic Imbalance in Chronic Heart Failure
Authors: Cittadini Antonio , Bossone Eduardo , Marra Alberto Maria , Arcopinto Michele , Bobbio Emanuele , Longobardi Salvatore , Cevara Carmine , Di Michele Sara , Saccà Luigi
Published: December 2015

A metabolic imbalance between anabolic drive and catabolic forces is commonly observed in chronic heart failure (CHF) patients, with the latter prevailing over anabolic hormones. Moreover, anabolic deficiencies are independent markers of poor prognosis. This finding represents a solid background for the implementation of therapeutic trials based on replacement therapy. The somatotropic axis (GH/IGF-1) is the most powerful anabolic axis of the body and its decline is related with a poor outcome and a worse clinical status. Growth hormone (GH) administration may enter the therapeutic arena as adjunctive treatment in patients affected by CHF and GH/IGF-1 deficiency. The T.O.S.CA. project aims at investigating the relationship between CHF and hormonal deficiency.
Job strain predicts recurrent events after a first acute myocardial infarction: The Stockholm Heart Epidemiology Program
Authors: Domenico Del Forno e Valentina Battimiello Commento bibliografico di
Published: December 2015

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Meconium pseudocyst associated with congenital CMV infection
Authors: Vlok Sucari , Du Plessis Vicci
Published: December 2015

Meconium pseudocyst is a rare complication of fetal bowel perforation in utero, following extravasation and localised containment of meconium within the intra-peritoneal cavity.
Heterotaxy syndrome: This is the left, right?
Authors: Huang Lili , Mitchell Belinda J. , Andronikou Savvas , Lockhat Zarina I. , Suleman Farhana
Published: December 2015

Heterotaxy syndrome is a rare and complex disorder of the chest and abdominal organ arrangements, and presents a diagnostic challenge to the radiologist. This article describes the morphological characteristics of heterotaxy and situs abnormalities, in particular left and right atrial isomerism, and suggests an approach in evaluating the spectrum of abnormalities associated with heterotaxy syndromes, using appropriate imaging modalities.
Sample Preparation of Eggs from Laying Hens Using QuEChERS Dispersive Extraction for the Simultaneous Determination of Melamine and Cyromazine Residues by HPLC-DAD
Authors: Tsartsali Niki , Samanidou Victoria F.
Published: December 2015

A quick, easy, cheap, effective, rugged, and safe (QuEChERS) dispersive extraction method is proposed herein for the isolation and cleanup of melamine and cyromazine from chicken egg yolk. Analytes are determined by high-performance liquid chromatography using photodiode array detector after separation on a LiChroCART® (250 × 4 mm)–-LiChrospher® RP-8e, 5 µm analytical column using a mobile phase of 0.1% trifluoracetic acid and methanol (80:20 v/v) delivered isocratically at a flow rate of 1 mL/minute. Extraction of isolated compounds was achieved by methanol and acetonitrile mixture (1:1 v/v). Recovery rates ranged between 74.5% and 115.8%. The method was validated in terms of 657/2002/EC decision. The within-laboratory reproducibility, expressed as a relative standard deviation, was <11%. Decision limits (CCalfa) were 2.56 mg/kg for melamine and 0.22 mg/kg-1 for cyromazine, and the corresponding results for detection capability (CCbeta) were 2.8 mg/kg for melamine and 0.24 mg/kg for cyromazine. Ruggedness was estimated according to the Youden approach studying egg yolk mass, sorbent mass, centrifugation time, organic solvents volume, evaporation temperature, and vortex time.
Sequence Analysis and Evolutionary Studies of Reelin Proteins
Authors: Manoharan Malini , Muhammad Sayyed Auwn , Sowdhamini Ramanathan
Published: December 2015

The reelin gene is conserved across many vertebrate species, including humans. The protein product of this gene plays several important roles in early brain development and regulation of neural network plasticity of a matured brain structure. With an extended structure of 3461 amino acid sequences, consisting of eight reelin repeats, the human reelin sequence stands out as an exceptional model for evolutionary studies. In this study, sequence analysis of the human reelin and its homologues and reelin sequences from 104 other species is described in detail. Interesting sequence conservation patterns of individual repeats have been highlighted. Sequence phylogeny of the reelin sequences indicates a pattern similar to the evolution of the species, thereby serving as a highly conserved family for evolutionary purposes. Multiple sequence alignment of different reelin domain repeats, derived from homologues, suggests specific functions for individual repeats and high sequence conservation across reelin repeats from different organisms, albeit with few unusual domain architectures. A three-dimensional structural model of the full-length human reelin is now available that provides clues on residues at the dimer interface.
Homology-Based Prediction of Potential Protein-Protein Interactions between Human Erythrocytes and Plasmodium falciparum
Authors: Ramakrishnan Gayatri , Srinivasan Narayanaswamy , Padmapriya Ponnan , Natarajan Vasant
Published: December 2015

Plasmodium falciparum, a causative agent of malaria, is a well-characterized obligate intracellular parasite known for its ability to remodel host cells, particularly erythrocytes, to successfully persist in the host environment. However, the current levels of understanding from the laboratory experiments on the host-parasite interactions and the strategies pursued by the parasite to remodel host erythrocytes are modest. Several computational means developed in the recent past to predict host-parasite/pathogen interactions have generated testable hypotheses on feasible protein-protein interactions. We demonstrate the utility of protein structure-based protocol in the recognition of potential interacting proteins across P. falciparum and host erythrocytes. In concert with the information on the expression and subcellular localization of host and parasite proteins, we have identified 208 biologically feasible interactions potentially brought about by 59 P. falciparum and 30 host erythrocyte proteins. For selected cases, we have evaluated the physicochemical viability of the predicted interactions in terms of surface complementarity, electrostatic complementarity, and interaction energies at protein interface regions. Such careful inspection of molecular and mechanistic details generates high confidence on the predicted host-parasite protein-protein interactions. The predicted host-parasite interactions generate many experimentally testable hypotheses that can contribute to the understanding of possible mechanisms undertaken by the parasite in host erythrocyte remodeling. Thus, the key protein players recognized in P. falciparum can be explored for their usefulness as targets for chemotherapeutic intervention.
Patterns of Local and Systemic Cytokines in Bacterial Meningitis and its Relation with Severity and Long-Term Sequelae
Authors: Perdomo-Celis Federico , Torres Miguel A. , Ostos Henry , Gutierrez-Achury Javier , Molano Victor , Durán Luis F. , Gonzalez Guillermo , Narváez Carlos F.
Published: December 2015

Bacterial meningitis (BM) is a pyogenic infection present in the subarachnoid space, potentially fatal and frequently associated with neurological sequelae. During BM, cytokines (CTs) are locally produced. We sought to determine the CTs’ clinical role as disease severity predictors in adults, which is not completely clear. Using a bead-based flow cytometric assay, levels of six CTs were determined in cerebrospinal fluid (CSF) and plasma from 18 adult BM patients and 19 uninfected controls. Long-term neurological sequelae were evaluated using the Glasgow Outcome Scale (GOS). All evaluated CTs were higher in CSF than in plasma, and the levels of CSF interleukin (IL)-6, IL-8, IL-10, IL-1β, and tumor necrosis factor-α and plasma IL-10 and IL-12p70 were significantly higher in patients with severe sepsis than with sepsis, suggesting an association with clinical severity. There was a strong negative correlation between CSF IL-6 and plasma IL-12p70 with GOS score, supporting the possible role of these CTs in the development of neurological long-term sequelae. These findings could be helpful to identify candidates to receive neuroprotective treatments and early physiotherapy schemes.
Simulation of the Protein-Shedding Kinetics of a Fully Vascularized Tumor
Authors: Frieboes Hermann B. , Curtis Louis T. , Wu Min , Kani Kian , Mallick Parag
Published: December 2015

Circulating biomarkers are of significant interest for cancer detection and treatment personalization. However, the biophysical processes that determine how proteins are shed from cancer cells or their microenvironment, diffuse through tissue, enter blood vasculature, and persist in circulation remain poorly understood. Since approaches primarily focused on experimental evaluation are incapable of measuring the shedding and persistence for every possible marker candidate, we propose an interdisciplinary computational/experimental approach that includes computational modeling of tumor tissue heterogeneity. The model implements protein production, transport, and shedding based on tumor vascularization, cell proliferation, hypoxia, and necrosis, thus quantitatively relating the tumor and circulating proteomes. The results highlight the dynamics of shedding as a function of protein diffusivity and production. Linking the simulated tumor parameters to clinical tumor and vascularization measurements could potentially enable this approach to reveal the tumor-specific conditions based on the protein detected in circulation and thus help to more accurately manage cancer diagnosis and treatment.
Symmetries of quasiplatonic Riemann surfaces
Authors: Jones Gareth A. , Singerman David , Watson Paul D.
Published: December 2015

We state and prove a corrected version of a theorem of Singerman, which relates the existence of symmetries (anticonformal involutions) of a quasiplatonic Riemann surface

\mathcal S

(one uniformised by a normal subgroup

N

of finite index in a cocompact triangle group

\Delta

) to the properties of the group

G=\Delta/N

. We give examples to illustrate the revised necessary and sufficient conditions for the existence of symmetries, and we relate them to properties of the associated dessins d'enfants, or hypermaps.
A Born approximation from backscattering data for live loads in Lamé system
Authors: Barceló Juan Antonio , Folch-Gabayet Magali , Pérez-Esteva Salvador , Ruiz Alberto , Cruz Vilela Mari
Published: December 2015

We will study the inverse scattering problem for the Lamé equation in elasticity with live loads. We give the definition of a Born approximation of the load from backscattering data. We will see that in 2D, for non-smooth load matrices the main singularities of the matrices are in fact contained in their Born approximations. The singularities are measured in the scale of Sobolev spaces.
Nonautonomous Dynamics with Discrete Time and Topological Equivalence
Authors: Barreira Luis , Popescu Liviu Horia , Valls Claudia
Published: December 2015

For evolution families with discrete time, we show that any exponential dichotomy is topologically equivalent to a certain normal form, in which the exponential behavior along the stable and unstable directions are multiples of the identity. We consider the general case of a generalized exponential dichotomy in which the usual exponential behavior is replaced by an arbitrary growth rate. In addition, we show that the topological equivalence between two evolution families with generalized exponential dichotomies can be completely characterized in terms of a notion of equivalence between the growth rates.
El diseño periodístico como actor fundamental en los modelos de prensa popular. Una aproximación a las causas del cierre del diario Claro
Authors: González Diez Laura , Puebla Martínez Belén , Birkner Thomas , Pérez Cuadrado Pedro
Published: December 2015

Este trabajo pretende demostrar la importancia del diseño periodístico a la hora de establecer una clasificación de los diarios impresos y de su vertiente popular/sensacionalista, donde los elementos formales  cobran un protagonismo fundamental. Se pretende acotar uno de los escasos intentos de consolidar en España un diario importante de información sensacionalista. En 1991, una extraña alianza de editores alemanes (Axel Springer) y españoles (Prensa Española, editora de Abc) pone en circulación el diario Claro, con la idea de conseguir un producto de difusión masiva. Metodología: Se plantea un trabajo de campo basado en el análisis de los elementos gráficos y tipográficos que –con una muestra íntegra de todos los ejemplares publicados– definen la estructura de la portada de un diario de esta índole y alertan del protagonismo de los recursos visuales implícitos a este modelo de prensa. Resultados y conclusiones: Claro se inscribe de lleno en los modelos de prensa sensacionalista de corte europeo, no sólo por el tipo de información que se ofrece sino, sobre todo, por la estructura y soporte que maneja y que lo convierten en ejemplo representativo del ámbito de la prensa popular más pura.
Addressing Medication Errors Involving HIV-Positive Inpatients: Development of a Clinician’s Guide to Assessing Antiretroviral Therapy
Authors: Pittman Elliot S , Li Emily H , Foisy Michelle M
Published: December 2015

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Should the Postgraduate Year 2 (PGY-2) Residency Be Focused on Advanced Pharmacy Practice Training?
Authors: Loewen Peter , Mills Allan , Harder Curtis , Walus Ashley N , Woloschuk Donna M M
Published: December 2015

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Effect of feed restriction and different crude protein sources on the performance, health status and carcass traits of growing rabbits
Authors: Uhlířová L. , Volek Z. , Marounek M. , Tůmová E.
Published: December 2015

We evaluate the effect of the crude protein source (CP) in combination with 2 feeding strategies (AL: ad libitum or R: restricted) on the performance, health status and carcass traits of growing-fattening rabbits (between 33 and 75 d of age). Two experimental diets were formulated; the first containing soybean meal (SBM: 70 g/kg) as the main CP source and the second containing white lupin seeds (WLS: 105 g/kg) as the main CP source. A total of 160 weaned Hyplus rabbits (774±10 g live weight) were randomly allocated to the experimental groups, combination of feeding strategy and diet (AL SBM, R SBM, AL WLS and R WLS; 40 rabbits per group with 4 rabbits per cage), for 42 d. The feeding programme was applied as follows: both the AL SBM and AL WLS rabbits were fed ad libitum for the entire fattening period, whereas the R SBM and R WLS rabbits were subjected to feed restriction between 33 and 47 d of age (75% of the ad libitum intake). Afterwards, all restricted rabbits were fed ad libitum until 75 d of age. Regardless of the CP source, the feed restriction reduced the final live weight by 83 g, chilled carcass weight by 65 g, and dressing out percentage by 0.9 percentage points (P<0.05). There was a higher chilled carcass weight (+114 g; P=0.001) and reference carcass weight (+91 g; P=0.001) in rabbits fed with WLS diet than in rabbits fed with SBM diet. No dead or morbid rabbits were observed in restricted rabbits during the restriction period. There was no effect of the diet on the health of rabbits. However when the rabbits of AL SBM and AL WLS group were compared did we observe a lower number of rabbits at sanitary risk in AL WLS group (2 vs. 12 rabbits, P=0.006). In conclusion, the growth performance was not affected by the crude protein source, and no interaction between dietary CP source and feeding regime was observed. Feed restriction regime did not improve sanitary risk index throughout the entire period.
Composite Resin Stamping Technique using a Translucent Hot Melt Adhesive
Authors: Dimashkieh Reda Mohiddin
Published: December 2015

Restoring a complex occlusal morphology of the posterior teeth is tremendously difficult when direct composite resin restorative materials are used because carving of the solid polymerized mass is accomplished mechanically using rotary instruments. The preoperative occlusal morphology of the tooth provides for the preparation of an ideal index of the esthetic and functional anatomy in cases where the carious lesion is confined within a shell of undermined yet intact enamel, and is registered using a transparent hot melt adhesive (HMA) material. The registration is then used as an index to reproduce the occlusal morphology in the final incremental restorative layer during the composite resin restoration, which also allows for the photopolymerization of the restoration through the translucent index.

How to cite this article

Dimashkieh RM. Composite Resin Stamping Technique using a Translucent Hot Melt Adhesive. Int J Prosthodont Restor Dent 2015;5(3):63-67.
The Relationship between Palatal Displacement of Upper Canines and Incisors Widths in a Syrian Sample of Patients with Uncrowded Arches
Authors: Mahaini Luai
Published: December 2015

The aim of this study investigates mesiodistal crown size of the maxillary and mandibular incisors of patients with palatally impacted canines (PDC). Pretreatment dental casts of orthodontic patients with PDC of one or both maxillary canines (N: 33) were collected. This PDC sample was matched according to age and sex with pretreatment dental casts from unaffected orthodontic patients. For the PDC and matched control samples, maximum mesiodistal crown diameters were recorded for the four incisors on the right side only. The results showed that, on average, the mesiodistal crown diameters for the maxillary and mandibular incisors measured smaller in the PDC sample than in the control sample. These findings of statistically significant tooth-size reductions associated with PDC occurrence indicate a generalized pattern of reduced tooth size as a characteristic associated with the PDC anomaly. Further, the presence of generalized tooth-size reduction in cases with palatally displaced canines help explain why most orthodontic treatment plans for PDC patients are of the nonextraction type.

How to cite this article

Mahaini L. The Relationship between Palatal Displacement of Upper Canines and Incisors Widths in a Syrian Sample of Patients with Uncrowded Arches. J Contemp Dent Pract 2015;16(11):873-875
Wikipedia: the difference between information acquisition and learning knowledge
Authors: Ochola J. Evans , Persson Dorothy M. , Schumacher Lisa A. , Lingo Mitchell D.
Published: December 2015

This paper attempts to define Wikipedia in an information literacy context by providing an analysis of learning knowledge and Wikipedia’s structure. The distribution of learning in the digital information age is a core topic for scholarly communication. It is highly relevant to students, citizens and instructors in their roles as users of content and as creators of content. Even though it appears to be far removed from traditional publishing in the print world, many students, citizens and instructors use digital information tools to share aspects of their works in a way that is defined as publishing. Understanding the difference between information acquisition and learning knowledge are essential in educational settings.