bluuebunny/crossref_metadata_2025 huggingface dataset:
Reflections on Norheim (2018), Disease Control Priorities Third Edition Is Published Comment on "Disease Control Priorities Third Edition Is Published: A Theory of Change Is Needed for Translating Evidence to Health Policy"
Authors: Nugent Rachel
Published: May 2019

The publication of Disease Control Priorities, 3rd edition (DCP3) is a major milestone in the global health world. DCP3 reviews and summarizes high quality health intervention effectiveness and cost-effectiveness evidence relevant to low- and middle-income countries and is freely available to users. This Commentary summarizes Norheim’s (2018) assessment of DCP3’s role in country health priority-setting and offers reflections on what DCP3 can continue to offer countries seeking to improve their purchasing of health.
Relevance of a Toll-Free Call Service Using an Interactive Voice Server to Strengthen Health System Governance and Responsiveness in Burkina Faso
Authors: Lechat Lucie , Bonnet Emmanuel , Queuille Ludovic , Traoré Zoumana , Somé Paul-André , Ridde Valéry
Published: May 2019

Background: In Africa, health systems are poorly accessible, inequitable, and unresponsive. People rarely have either the confidence or the opportunity to express their opinions. In Burkina Faso, there is a political will to improve governance and responsiveness to create a more relevant and equitable health system. Given their development in Africa, information and communication technologies (ICTs) offer opportunities in this area. Methods: This article presents the results of an evaluation of a toll-free call service coupled with an interactive voice server (TF-IVS) tested in Ouagadougou, Burkina Faso, to assess its relevance for improving health systems governance. The approach consisted of a 2-phased action research project to test 2 technologies: recorded messages and touch keypad. Using a concurrent mixed approach, we assessed the technological, social, and instrumental relevance of the service. Results: The call service is available everywhere, 24 hours per day, seven days per week. The equipment and its physical location were not adequately protected against technological hazards. Of the 278 days of operation, 49 were non-functional. In 8 months, there were 13 877 calls, which demonstrated the popularity of ICTs and the ease of access to telephone networks and mobile technologies. The TF-IVS was free, anonymous, and multilingual, which fostered the expression of public opinion. However, cultural context (religion, ethnic culture) and fear of reprisals may have had a negative influence. In the end, questions remained regarding people’s capacity to use this innovative service. In the first trial, 49% of callers recorded their message and in the second, 48%. Touch key technology appeared more relevant for automated and real-time data collection and analysis, but there was no comprehensive strategy for translating the information collected into a response from healthcare actors or the government. Conclusion: This study showed the relevance and feasibility of implementing a TF-IVS to strengthen health system responsiveness in one of the world’s poorest countries. Public opinion expressed through data collected in real-time is helpful for improving system responsiveness to meet care needs and enhance equity. However, the strategy for developing this tool must take into account the implementation context and the activities needed to influence the mechanisms of social responsibility (eg, information provision, citizen action, and state response).
Political Ideology and Stigmatizing Attitudes Toward Depression: The Swedish Case
Authors: Löve Jesper , Bertilsson Monica , Martinsson Johan , Wängnerud Lena , Hensing Gunnel
Published: May 2019

Background: Stigmatizing attitudes toward persons with mental disorders is a well-established and global phenomenon often leading to discrimination and social exclusion. Although previous research in the United States showed that conservative ideology has been related to stigmatizing attitudes toward mental disorders, there is reason to believe that this mechanism plays a different role in the context of a universal welfare state with a multi-party system such as Sweden. Furthermore, "mental disorders" may signify severe psychotic disorders, which may evoke more negative attitudes. This suggests the importance of specific studies focusing on the more common phenomenon of depression. This paper investigates the relationship between political ideology and stigmatizing attitudes toward depression in Sweden. Methods: This study is part of the New Ways research program. Data were collected by the Laboratory of Opinion Research (LORE) at the University of Gothenburg in 2014 (N = 3246). Independent variables were political ideology and party affiliation. The dependent variable was the Depression Stigma Scale (DSS). Data were analyzed with linear regression analyses and analyses of variance. Results: More conservative ideology (B = 0.68, standard error [SE] = 0.04, P<.001) and more conservative party affiliation (F(8 2920) = 38.45, P<.001) showed more stigmatizing attitudes toward depression. Item-level analyses revealed a difference where the supporters of the conservative party differed (P<.05) from supporters of the liberal party, with a higher proportion agreeing that "people could snap out of " depression if they wanted to; the populist right-wing party differed from the conservative party with a higher proportion agreeing on items displaying people with depression as "dangerous" and "unpredictable." Even self-stigma was highest among the populist right-wing party with 22.3% agreeing that "if I had depression I wouldn’t tell…." Conclusion: Political ideology was associated with stigmatizing attitudes toward depression in Sweden. The results also confirm the need to distinguish between different forms of conservatism by observing social distance as being a more important driver among voters for the populist right-wing party compared with personal agency and responsibility among voters for the more traditional conservative party.
A Crisis of Humanitarianism: Refugees at the Gates of Europe
Authors: Fotaki Marianna
Published: May 2019

Having initially welcomed more than a million refugees and forced migrants into Europe between 2015 and 2016, the European Union’s (EU’s) policy has shifted toward externalising migration control to Turkey and Northern Africa. This goes against the spirit of international conventions aiming to protect vulnerable populations, yet there is widespread indifference toward those who remain stranded in Italy, Greece and bordering Mediterranean countries. Yet there are tens of thousands living in overcrowded reception facilities that have, in effect, turned into long-term detention centres with poor health and safety for those awaiting resettlement or asylum decisions. Disregard for humanitarian principles is predicated on radical inequality between lives that are worth living and protecting, and unworthy deaths that are unseen and unmarked by grieving. However, migration is on the rise due to natural and man-made disasters, and is becoming a global issue that concerns us all. We must therefore deal with it through collective political action that recognises refugees’ and forced migrants’ right to protection and ensures access to the health services they require.
Nonlinear Elastic Effects on High-Strength Concrete Stress Invariants
Authors: Nogueira Carnot L.
Published: May 2019

Computational modeling of concrete behavior and most failure criteria for concrete strongly rely on the use of invariants of stress. These invariants allow a straightforward geometric interpretation of stress states and concrete failure surfaces in the three-dimensional Haigh-Westergaard stress space. Although second-order linear elastic relations have been traditionally applied to evaluate stresses in concrete, the magnitudes of concrete third-order parameters based on finite deformation theory—Murnaghan parameters l, m, n—are such that, if nonlinear stress-strain relations are considered, the stress invariants’ magnitudes are directly affected. In this work, acoustoelastic stress-strain relations for a general triaxial stress state and ultrasonically calculated second- and third-order elastic parameters are used in the evaluation of three high-strength concrete mixtures with compressive strengths: f′c = 43.0, 44.8, and 56.0 MPa (6.2, 6.5, and 8.1 ksi, respectively). The results demonstrate that nonlinear elastic effects introduce anisotropy when uniaxial stresses are applied and the magnitudes of concrete elastic and shear moduli change because of the applied stress field. When triaxial loads are considered, all stress invariants—first (I1), second (I2), and third (I3)—also undergo variations in their magnitudes. The stress-induced anisotropy due to uniaxial loading application and also the changes in the stress invariants’ magnitudes calls attention to the importance of considering nonlinear third-order effects in cement-based materials’ stress-strain relations and failure criteria.
Experimental Analysis on Creep Properties of Frozen Silty Mudstone Considering Conservation of Energy
Authors: Liu Xiaoyan , Liu Lulu , Li Zhe , Yao Zhaoming
Published: May 2019

The artificial ground freezing method is a dominant technique during the construction of massive coal mines and tunnels. The comprehensive understanding of creep properties, especially the accelerating creep process of frozen soft rock, can provide significant guidance regarding the excavation of the soft rock layer. In this article, a series of uniaxial compression tests and creep tests of silty mudstone samples was conducted. In conjunction with the experimental data, the creep properties of frozen silty mudstone at transient, steady, and accelerating creep stages are discussed in detail. Furthermore, based on the conservation of energy, a winding element is introduced to modify the classical Nishihara model, which reveals that the modified Nishihara model not only presents the creep-damage properties of frozen silty mudstone at the accelerating creep stage but also describes the primary and stationary creep stages accurately. Moreover, the fitted results using the modified Nishihara model are in good agreement with the test results. Ultimately, the results of sensitivity analyses corroborate that small changes in the stress level can cause large changes in the failure time. At the accelerating creep stage, the axial strain rate increases more rapidly when the coefficient winding element is small, causing a shorter time to approach failure. This modified creep model can present a theoretical basis for further revealing the objective law of rock creep and can provide an important reference for the safety assessment of coal mine and tunnel construction using the artificial ground freezing method.
Vehicular Light Weighting by Finite Element Simulation of E Glass–Based Composite Automotive Seat
Authors: Sinha Medhavi , Tyagi R. K.
Published: May 2019

The automobile industry has demonstrated itself to be one of the most quickly growing industries. However, the growth in the automotive industry has direct implications for fossil fuel reserves. The vigorously depleting fossil fuel reserves, the eminently increasing petroleum prices, the constant increase in pollution levels, and the hazardous effects of atmospheric environmental degradation are the driving forces for gravitation toward vehicular light weighting. The current article discuses the process of lightening the weight of front car seats, which is one of the most indispensable components of the automobile. This article demonstrates the feasibility of replacing metal automotive seats with E-Glass–based fiber-reinforced polymer (FRP) composite automotive seats. Various types of investigations and comparative analyses, such as analysis for displacement, force, force-to-weight ratio, maximum and minimum stresses, and unit cost of fiber composites, are performed on the conventional car seat composed of steel alloy 4340 and that composed of FRP composites. It can be demonstrated from the various analyses that a substantial weight reduction of front car seat is obtained with respect to alloy steel when FRPs are used as substitutional materials. The weight of the steel alloy front car seat is reduced by 79.76 % with the utilization of carbon fiber composite as an alternative material, whereas the component weight was reduced by 57.27 and 70.31 % with the utilization of glass fiber composite and Kevlar materials, respectively. A cost analysis is also performed, and it is determined that the costs of carbon fiber composite, glass fiber composite, and Kevlar are quite a bit higher than that of alloy steel. The stress analysis for alloy steel and fiber composites exhibits that the maximum stresses of glass fiber composite, carbon fiber composite, and Kevlar are about 1.95, 2.96, and 2.40 times higher than alloy steel.
Análise linguística integrada à leitura: contribuições para a prática docente em língua portuguesa
Authors: De Souza Liliane Vanilde , Alano Natassia D’Agostin , Dias Sabatha Catoia
Published: May 2019

Este artigo tem como objetivo discutir a importância da análise linguística integrada ao ensino e à aprendizagem de leitura nas aulas de Língua Portuguesa no contexto de escolas de Educação Básica. As bases teórico-epistemológicas e metodológicas que sustentam este artigo são a perspectiva bakhtiniana em diálogo com estudos sociocognitivistas. A discussão decorre de uma preocupação com o tradicional trabalho de análise gramatical ainda presente em aulas de Língua Portuguesa, pautado em leituras descontextualizadas de textos, na maioria das vezes, fragmentados. Nosso propósito, desse modo, é contribuir, em alguma medida, com a prática docente no que diz respeito à análise da língua em articulação com a leitura de textos em gêneros do discurso diversos, de modo a delinear possibilidades ao trabalho escolar.
Do vídeo à denúncia: representação do estupro coletivo no Twitter e estratégias discursivas
Authors: Resende Viviane De Melo , Rabelo Nair
Published: May 2019

Com base na abordagem teórico-metodológica da Análise de Discurso Crítica (ADC), este artigo propõe investigação acerca de discursos sobre violência contra mulheres, manifestos na rede social Twitter. Assim, propomos análise de textos referentes a um caso particular: o estupro coletivo de uma adolescente no Rio de Janeiro, em 21 de maio de 2016. Causando comoção no país, o caso se tornou conhecido por meio de um vídeo gravado pelos agressores registrando o estupro. São tomadas como corpus postagens de dois ambientes de fala: uma organização da sociedade civil de enfrentamento à violência contra mulheres e dois perfis oficiais do poder público executivo federal. Buscamos analisar como os crimes foram representados; como a jovem agredida foi representada; como a organização não governamental expandiu o debate; se houve mudanças na abordagem do caso ao longo do tempo; como páginas ligadas ao poder público executivo federal responderam à extremada violência e à repercussão social.
Descriptive Analysis of Student’s Self Efficacy in The Discovery Learning Processes
Authors: Mufida Husna Noor , Linuwih Suharto , Sugianto Sugianto
Published: May 2019

This research aims to describe the state of self efficacy on the application of learning discovery learning model on harmonic vibration topic. In addition to reveal the factors that influence the increase or decrease of students' self efficacy with the application of discovery learning model. This research is a qualitative descriptive analysis research. Discovery learning model is implemented in 38 students class X MIPA 2 of SMA 1 Bae Kudus. Data collection was done by giving questionnaires, observation, and interview. Questionnaire of student’s self efficacy also has been given to determine the condition of self efficacy of students before and after the learning process implemented. The results showed that the initial self efficacy condition of students who had low initial increase although not significant. The condition of early efficacy of students before the learning process determines the level of student success in the learning process. Analysis of the first time self efficacy of students with the low category can be used as an anticipation or prevent the final learning outcomes of students do not become low.
The Effectiveness of Physics Teaching Materials on The Theme of “Global Warming Symptoms” based on Scientific Literacy to Increase The Students’ Cognitive Abilities
Authors: Purwiyantini Yeni , Rusilowati Ani , Astuti Budi
Published: May 2019

The purpose of this research is to develop teaching materials based on scientific literacy with categories of scientific literacy that isbalanced, feasible to use, easy to understand, and improve students’ cognitive ability. The study used pre-test and post-test control group design. Based on the results of the research, the ratio of the content of scientific literacy in the teaching materials developed with the ratio of 40%: 20%: 20%: 20%. Teaching materials are considered feasible to use with an average score of 91.67% eligibility score and legibility with an average score of 89.47%. The improvement of scientific literacy ability of students using scientific-based literacy materials was 0,51 while the students who used teaching materials circulating in school was 0,26. In the experimental class had increased of cognitive learning outcomes and the average of affective and psychomotor learning outcomes were higher than control class. This shows the literacy-based materials science material symptom of Global Warmingcould improve the ability of scientific literacy.
Development of Interactive Media-Based Wave Teaching Materials to Improve Students' Problem and Performance Capability
Authors: Ahsani Muh Syukri , Yulianto Agus , Sarwi Sarwi
Published: May 2019

This study aims to produce teaching materials to improve problem-solving skills that are feasible to use as a class XII physics learning media on sound wave material. In addition, it is also to find out the response of students to teaching materials developed in terms of meeting the standards of usability and quality. This research is R & D research with design according to Borg including: needs analysis, product planning and development, product development, product evaluation, and final products. The instructional materials developed have been implemented in 63 students of class XII SMAN 5 Semarang. Data collection is done by giving a validation sheet to the senior teacher. Data on students 'problem solving abilities were obtained from the results of the pretest and posttest while the students' performance was seen from the observation of practical activities in the laboratory. Students are also given a questionnaire to provide input on the teaching materials that have been developed. The results of the study indicate that the product of development is declared feasible based on expert judgment. Implementation of teaching materials in physics learning in sound wave material is able to improve problem solving skills and student performance.
EJE AWARD 2019: New diagnostic approaches for patients with polyuria polydipsia syndrome
Authors: Christ-Crain Mirjam
Published: May 2019

Diabetes insipidus (DI), be it from central or nephrogenic origin, must be differentiated from secondary forms of hypotonic polyuria such as primary polydipsia. Differentiation is crucial since wrong treatment can have deleterious consequences. Since decades, the gold standard for differentiation has been the water deprivation test, which has limitations leading to an overall unsatisfying diagnostic accuracy. Furthermore, it is cumbersome for patients with a long test duration. Clinical signs and symptoms and MRI characteristics overlap between patients with DI and primary polydipsia. The direct test including vasopressin (AVP) measurement upon osmotic stimulation was meant to overcome these limitations, but failed to enter clinical practice mainly due to technical constraints of the AVP assay. Copeptin is secreted in equimolar amount to AVP but can easily be measured with a sandwich immunoassay. A high correlation between copeptin and AVP has been shown. Accordingly, copeptin mirrors the amount of AVP in the circulation and has led to a ‘revival’ of the direct test in the differential diagnosis of DI. We have shown that a baseline copeptin, without prior thirsting, unequivocally identifies patients with nephrogenic DI. In contrast, for the differentiation between central DI and primary polydipsia, a stimulated copeptin level of 4.9 pmol/L upon hypertonic saline infusion differentiates these two entities with a high diagnostic accuracy and is superior to the water deprivation test. Close sodium monitoring during the test is a prerequisite. Further new test methods are currently evaluated and might provide an even simpler way of differential diagnosis in the future.
Neuromedin B receptor disruption impairs adipogenesis in mice and 3T3-L1 cells
Authors: de Paula Gabriela Silva Monteiro , Wilieman Marianna , Silva Karina Ribeiro , Baptista Leandra Santos , Boudina Sihem , de Souza Luana Lopes , Bento-Bernardes Thais , Asensi Karina Dutra , Goldenberg Regina Coeli dos Santos , Pazos-Moura Carmen Cabanelas
Published: May 2019

Neuromedin B, a bombesin-like peptide, and its receptor, are expressed in white adipose tissue with undefined roles. Female mice with disruption of neuromedin B receptor (NB-R) exhibited partial resistance to diet-induced obesity leading to our hypothesis that NB-R is involved in adipogenesis. Here, we showed that adipose stem/stromal cells (ASC) from perigonadal fat of female NB-R-knockout mice, exposed to a differentiation protocol in vitro, accumulated less lipid (45%) than wild type, suggesting reduced capacity to differentiate under adipogenic input. To further explore mechanisms, preadipocytes 3T3-L1 cells were incubated in the presence of NB-R antagonist (PD168368) during the first 3 days in culture. Cells were analyzed in the end of the treatment (Day 3) and later when fully differentiated (Day 21). NB-R antagonist induced lower number of cells at day 3 and 21 (33–39%), reduced cell proliferation at day 3 (−53%) and reduced lipid accumulation at day 21 (−86%). The mRNA expressions of several adipocyte differentiation markers were importantly reduced at both days: Cebpb and Pparg and Fabp4, Plin-1 and Adipoq, and additionally Lep mRNA at day 21. The antagonist had no effect when incubated with mature 3T3-L1 adipocytes. Therefore, genetically disruption of NB-R in mice ASC or pharmacological antagonism of NB-R in 3T3-L1 cells impairs adipogenesis. The mechanisms suggested by results in 3T3-L1 cells involve reduction of cell proliferation and of early gene expressions, leading to decreased number of mature adipocytes. We speculate that NB-R antagonism may be useful to limit the increase in adiposity due to pre-adipocyte differentiation.
The Prophylactic Effect of Proton Pump Inhibitors Combined with Enteral Nutrition for Preventing Gastrointestinal Hemorrhage after Cardiovascular Surgery in High-Risk Patients
Authors: Chen Mei-Fang , Lin Yong , Chen Liang-Wan
Published: May 2019

Background: Gastrointestinal hemorrhage (GH) is one of the most serious complications after cardiovascular surgery. The aim of the study was to provide an optimal therapeutic strategy for preventing postoperative GH in high-risk patients. Methods: This retrospective case-control study included 188 adult patients at high risk of postoperative GH. These patients were divided into two groups based on a strategy for preventing postoperative GH: Group A (n = 97) received continuous intravenous infusion of proton-pump inhibitor (PPI) combined with early enteral nutrition, and Group B (n = 91) received a bolus intravenous infusion of PPI combined with late enteral nutrition. The clinical features of the groups were examined.
Results: The incidence of postoperative GH in the patients of group A was significantly lower than the patients in group B. The duration from the end of surgery to eating for the first time in the patients of group A was significantly shorter than in the patients of group B. A descending trend in 30-day mortality was observed in the patients of group A compared with group B, but no significant difference was found between the two groups.
Conclusion: Continuous intravenous infusion of PPI combined with early enteral nutrition could effectively prevent GH and reduce 30-day mortality after cardiovascular surgery in high-risk patients.
Predictors of In-Hospital Mortality in Isolated Total Anomalous Pulmonary Venous Connection
Authors: Elamry Eslam , Alkady Hesham Mostafa , Menaissy Yasser , Abdalla Osama
Published: May 2019

Background: We assessed risk factors for early mortality in isolated total anomalous pulmonary venous connection over a modern era excluding emergent cases to eliminate the influence of associated factors on surgical outcome. 
Methods: 70 patients with isolated total anomalous pulmonary venous connection who were repaired electively between January 2013 and February 2018 were included.
Results: In-hospital mortality was encountered in 4 patients (5.7%). Upon univariate analysis, low age (P = .003) and weight (P = .001) at surgery, preoperative pulmonary venous obstruction (P = .010), preoperative low oxygen saturation (P = .031), long cardiopulmonary bypass (P = .001) and aortic cross clamp (P = .003) times, long duration of mechanical ventilation (P = .001), chest infection (P = 0.041), postoperative low CO syndrome (P < .001) and long postoperative inotropic support (P = .015) were significant predictors of in-hospital mortality. In multivariate analysis postoperative low cardiac output syndrome (OR: 1.060; 95% CI: 1.008-1.116) and prolonged postoperative mechanical ventilation (OR: 1.772; 95% CI: 1.141-2.751) were independent factors of in-hospital mortality.
Conclusion: Surgical repair of TAPVC is now performed with acceptable results. According to our study, postoperative low cardiac output syndrome and prolonged postoperative mechanical ventilation were the most significant predictors for early mortality.
Single-Copy Knock-In Loci for Defined Gene Expression inCaenorhabditis elegans
Authors: Silva-García Carlos G , Lanjuin Anne , Heintz Caroline , Dutta Sneha , Clark Nicole M , Mair William B
Published: May 2019

We have generated a single-copy knock-in loci for defined gene expression (SKI LODGE) system to insert any DNA by CRISPR/Cas9 at defined safe harbors in the Caenorhabditis elegans genome. Utilizing a single crRNA guide, which also acts as a Co-CRISPR enrichment marker, any DNA sequence can be introduced as a single copy, regulated by different tissue-specific promoters. The SKI LODGE system provides a fast, economical, and effective approach for generating single-copy ectopic transgenes in C. elegans.
EL SISTEMA DE GESTIÓN DE RIESGOS Y SU IMPACTO EN LA INFORMACIÓN CONTABLE DEL SISTEMA BANCARIO
Authors: Paillacar Silva Carlos , Hidalgo Tupia Manuel Alberto , Orellano Antunez Juan Carlos
Published: May 2019

Objetivo: El articulo se enfoca en determinar la relación que hay entre una adecuada aplicación del sistema de gestión de riesgos bancarios incluida en las normas de la Superintenencia de Banca, Seguros y Administradoras de Fondos de Pensiones del Perú con la aplicación de las normas de formulación de la información contable en el sistema bancario. Método: Se trata de investigación correlacional, transversal y aplicativa. Para probar la relación se utilizó una encuesta aplicada a expertos, debido a que los bancos no brindaron información directa. Se determinaron asimismo los factores que afectan la adecuada aplicación de la gestión de riesgos; aplicándose el índice de correlación R de Pearson. Resultados: Se demostró con un índice de 96,7%, con un nivel de significancia del 95%, que la pertinencia del sistema de gestión de riesgos bancarios contenida en la normativa de la regulación bancaria tiene un impacto en la calidad de la información contable midiendo en cada caso su impacto. Conclusiones: La pertinencia del sistema de gestión de riesgos bancarios contenida en la normativa de la regulación bancaria tiene un impacto en la calidad de la información contable del sistema bancario en el Perú.
CUMPLIMIENTO NORMATIVO SOBRE IMPUESTO A LAS GANANCIAS REPORTADOS POR EMPRESAS BURSÁTILES BAJO NIIF
Authors: Vilchez Olivares Percy Antonio
Published: May 2019

Objetivo: Evaluar el nivel de cumplimiento normativo de las NIIF respecto a la aplicación de la NIC 12 Impuesto a las ganancias en la información financiera que reportan y publican las empresas con cotización bursátil en la Bolsa de Valores de Lima por el período terminado el 2016. Método: Es una investigación de tipo práctica, descriptiva, cuantitativa y no experimental, con procesamiento de data numérica a través de análisis estadístico. Resultados: La muestra fue de 52 empresas de los estratos industriales, mineras y de servicio público, a quienes se les revisó las frecuencias de cumplimiento de información financiera bajo NIIF determinándose que las empresas que reportan no cumplen al 100% con las regulaciones planteadas por la NIC 12 Impuesto a las ganancias. Conclusiones: La información financiera preparada bajo NIIF y reportadas por las empresas industriales, mineras y de servicio público posee una alta propensión al cumplimiento de los criterios normativos de la NIC 12 Impuesto a las ganancias respecto a la presentación y revelación de información sobre impuesto a las ganancias.
Long QT Syndrome Modelling with Cardiomyocytes Derived from Human-induced Pluripotent Stem Cells
Authors: Sala Luca , Gnecchi Massimiliano , Schwartz Peter J
Published: May 2019

Long QT syndrome (LQTS) is a potentially severe arrhythmogenic disorder, associated with a prolonged QT interval and sudden death, caused by mutations in key genes regulating cardiac electrophysiology. Current strategies to study LQTS in vitro include heterologous systems or animal models. Despite their value, the overwhelming power of genetic tools has exposed the many limitations of these technologies. In 2010, human-induced pluripotent stem cells (hiPSCs) revolutionised the field and allowed scientists to study in vitro some of the disease traits of LQTS on hiPSC-derived cardiomyocytes (hiPSC-CMs) from LQTS patients. In this concise review we present how the hiPSC technology has been used to model three main forms of LQTS and the severe form of LQTS associated with mutations in calmodulin. We also introduce some of the most recent challenges that must be tackled in the upcoming years to successfully shift hiPSC-CMs from powerful in vitro disease modelling tools into assets to improve risk stratification and clinical decision-making.
A Review of Driving Restrictions in Patients at Risk of Syncope and Cardiac Arrhythmias Associated with Sudden Incapacity: Differing Global Approaches to Regulation and Risk
Authors: Margulescu Andrei D , Anderson Mark H
Published: May 2019

The ability to drive is a highly valued freedom in the developed world. Sudden incapacitation while driving can result in injury or death for the driver and passengers or bystanders. Cardiovascular conditions are a primary cause for sudden incapacitation and regulations have long existed to restrict driving for patients with cardiac conditions at high risk of sudden incapacitation. Significant variation occurs between these rules in different countries and legislatures. Quantification of the potential risk of harm associated with various categories of drivers has attempted to make these regulations more objective. The assumptions on which these calculations are based are now old and less likely to reflect the reality of modern driving. Ultimately, a more individual assessment of risk with a combined assessment of the medical condition and the patient’s driving behaviour may be appropriate. The development of driverless technologies may also have an impact on decision making in this field.
Monomorphic Ventricular Arrhythmias in Athletes
Authors: Hsu Jeffrey J , Nsair Ali , Aboulhosn Jamil A , Horwich Tamara B , Dave Ravi H , Shannon Kevin M , Boyle Noel G , Shivkumar Kalyanam , Bradfield Jason S
Published: May 2019

Ventricular arrhythmias are challenging to manage in athletes with concern for an elevated risk of sudden cardiac death (SCD) during sports competition. Monomorphic ventricular arrhythmias (MMVA), while often benign in athletes with a structurally normal heart, are also associated with a unique subset of idiopathic and malignant substrates that must be clearly defined. A comprehensive evaluation for structural and/or electrical heart disease is required in order to exclude cardiac conditions that increase risk of SCD with exercise, such as hypertrophic cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy. Unique issues for physicians who manage this population include navigating athletes through the decision of whether they can safely continue their chosen sport. In the absence of structural heart disease, therapies such as radiofrequency catheter ablation are very effective for certain arrhythmias and may allow for return to competitive sports participation. In this comprehensive review, we summarise the recommendations for evaluating and managing athletes with MMVA.
Implantable Cardiac Electronic Devices in the Elderly Population
Authors: Lim Wei-Yao , Prabhu Sandeep , Schilling Richard J
Published: May 2019

The use of cardiac implantable electronic devices in the management of patients with heart rhythm conditions is well established. As the population ages, the use of cardiac implantable electronic devices in the elderly is likely to increase. This review provides a summary of the indications, implantation considerations and pragmatic advice on how to approach the use of these devices in this group of patients.
Acquired Long QT Syndrome and Electrophysiology of Torsade de Pointes
Authors: El-Sherif Nabil , Turitto Gioia , Boutjdir Mohamed
Published: May 2019

Congenital long QT syndrome (LQTS) has been the most investigated cardiac ion channelopathy. Although congenital LQTS remains the domain of cardiologists, cardiac electrophysiologists and specialised centres, the much more frequently acquired LQTS is the domain of physicians and other members of healthcare teams required to make therapeutic decisions. This paper reviews the electrophysiological mechanisms of acquired LQTS, its ECG characteristics, clinical presentation, and management. The paper concludes with a comprehensive review of the electrophysiological mechanisms of torsade de pointes.
Expanding the geographical distribution of Rhynchocypris czekanowskii (Dybowski, 1869) (Cypriniformes, Cyprinidae) in the basin of the Yenisei River, Eastern Siberia, Russia
Authors: Zuev Ivan Vladimirovich , Chuprov Sergei Mikhailovich , Zueva Anastasiya Vyacheslavovna
Published: May 2019

The currently known geographical distribution of Chekanovskii’s Minnow, Rhynchocypris czekanowskii (Dybowski, 1869), is limited only by the lower reaches of the arctic river basins in which this species lives. We report R. czekanowskii from the small water bodies of middle part of Yenisei river basin, expanding its distribution to the south of the river basin to 55°51ʹ41ʺ N latitude, more than 100 km south from previously known occurrences of this species.
70 Anos da Declaração Universal dos Direitos Humanos: Perspectivas Críticas – Entrevista com José J. Queiroz
Authors: De Oliveira Adelino Francisco , Bragion Alexandre Mauro
Published: May 2019

Professor emérito da Universidade Católica de São Paulo (PUC-SP) e um dos nomes mais celebrados no campo da pós-graduação em “Ciência da Religião”,José J. Queiroz foi também um militante contumaz na luta pelos Direitos Humanos no Brasil. Sua trajetória docente, religiosa, militante e de vida constitui-se numa constelação de ações marcantes e inspiradoras na seara da valorização da vida humana e do respeito à diversidade em todos os seus matizes. Em especial, sua trajetória profissional relacionada à defesa dos direitos humanos, às vicissitudes desses direitos no mundo atual e à importância da educação para que os direitos humanos sejam entendidos, respeitados e praticados é hoje uma trilha a ser estudada e melhor conhecida por quem atua também nessa mesma senda humanista. Ao lado de outros líderes também devotados à luta pelos direitos dos seres humanos, como o também celebrado religioso Dom Paulo Evaristo Arns, José J. Queiroz dedicou-se ainda a refletir e a escrever sobre o contemporâneo – seus símbolos, sua complexidade e idiossincrasias. Doutor em Direito Canônico pela PontificiaStudiorumUniversitas A. S. Thoma Aq. im Urbe, mestre em Teologia e graduado em Direito e Filosofia, a produção teórica de José J. Queiroz aborda ainda, e como não poderia deixar de ser, a ética – ou a falta dela – no contemporâneo. Seus livros “A Ética no Mundo de Hoje,”“A Educação Popular nas Comunidades Eclesiais de Base” e “A Religiosidade do Povo” – todos publicados pelas Edições Paulinas – são hoje, dentre outros livros de sua autoria, leitura obrigatória a todos os que, ocupados e preocupados com a educação popular e com a educação para os Direitos Humanos, dedicam-se a conhecer com mais profundidade essa importante temática.  Nesta entrevista que ora se apresenta ao leitor, José J. Queiroz nos expõe um pouco mais de perto o que pensa sobre o contemporâneo e sobre o respeito ao Direitos Humanos no Brasil e no mundo, à medida que – também – nos instiga e nos anima a seguir lutando sempre por eles e por aqueles que, na contemporaneidade, deles mais necessitam – os oprimidos.
A organização político-social do proletariado e a prefiguração dos Direitos Fundamentais
Authors: Araújo Neto Adalberto Coutinho , Oliveira Vítor Medina dos Santos
Published: May 2019

Este artigo discute a relação entre os Direitos Humanos e as reivindicações e atuação do movimento operário, internacional e brasileiro, em fins do século XIX. A perspectiva é a da prefiguração dos direitos sociais e políticos presentes na Declaração Universal dos Direitos Humanos nas reivindicações operárias internacionais e brasileiras, em particular e sua correspondência. Tomamos como objeto principal as vertentes do movimento operário orientadas e dirigidas pelos socialistas.
Educação em direitos humanos na pós-graduação: um relato de experiência discente
Authors: Gutierrez Elaine Cristina , Barros Nayara Natalia de , Lima Filho Nivaldo Guidolin de , Almeida Raimunda Ferreira de
Published: May 2019

O objetivo geral deste artigo é realizar um relato de experiência a respeito das visões, perspectivas e pretensões dos discentes da primeira oferta do curso de Pós-Graduação Lato Sensu em Educação em Direitos Humanos do IFSP, Câmpus Piracicaba. Este texto é produzido no contexto do aniversário de 70 anos da aprovação da Declaração Universal dos Direitos Humanos e em tempos de retrocessos na garantia dos direitos na sociedade brasileira. Acredita-se que esse panorama histórico e nacional influencia as respostas obtidas nos questionários semiabertos autoaplicados ao conjunto dos alunos de diferentes trajetórias profissionais e áreas do conhecimento, que participam da especialização. Com esses dados, buscamos compreender as motivações individuais para o ingresso no curso e identificar possíveis pontos de convergência entre os distintos campos de atuação dos discentes. Os resultados apontam para um movimento que parte da prática em direção à busca pela teoria, para a formalização de conhecimentos cotidianos e de senso comum, a respeito da temática dos direitos humanos e da educação – formal e não formal.
Ultrasonographic evaluation of the fetal central nervous system: review of guidelines
Authors: Milani Hérbene José Figuinha , Barreto Enoch Quindere de Sá , Araujo Júnior Edward , Peixoto Alberto Borges , Nardozza Luciano Marcondes Machado , Moron Antonio Fernandes
Published: May 2019

Abstract Central nervous system malformations constitute the second most common group of anomalies in fetuses. Such malformations have assumed clinical importance because of their association with high rates of perinatal morbidity and mortality. Therefore, it is extremely important to assess the fetal central nervous system during the prenatal period, in order to identify any changes in its development and thereby gain sufficient information to advise parents about pregnancy follow-up, options for fetal therapy, and the timing/type of delivery, as well as the postnatal treatment and prognosis. The objective of this review was to describe the ultrasonographic evaluation of the fetal central nervous system as per the guidelines of the International Society of Ultrasound in Obstetrics and Gynecology.
Avaliação da acurácia do exame ultrassonográfico em pacientes portadores de hérnia inguinal.
Authors: Duarte Bárbara Henriqueta Ferreira , Iamarino Ana Paula Marconi , Gabor Silvio , Favaro Murillo de Lima , Juliano Yara , Novo Neil Ferreira , Ribeiro Júnior Marcelo Fontenelle
Published: May 2019

RESUMO Objetivo: avaliar a acurácia da ultrassonografia no diagnóstico de hérnia inguinal no pré-operatório de pacientes submetidos à herniorrafia inguinal. Métodos: estudo retrospectivo descritivo, analítico, baseado em dados obtidos dos prontuários de pacientes submetidos à herniorrafia inguinal entre janeiro de 2016 e dezembro de 2017 e que realizaram ultrassonografia no período pré-operatório. A amostra foi composta por 232 pacientes e foram comparados os resultados da ultrassonografia com as queixas, exame físico e achados intraoperatórios desses pacientes. Resultados: a ultrassonografia apresentou concordância com a queixa de hérnia inguinal em 52% dos pacientes (p=0,019). Houve discordância entre a porcentagem de pacientes que apresentaram hérnia ao exame físico não confirmada pelo exame ultrassonográfico (28,57%) e a porcentagem de hérnias identificadas somente ao exame complementar (8,93%), com significância estatística (p=0,0291). Quando comparados os resultados ultrassonográficos com achados intraoperatórios, 32,70% dos pacientes que apresentavam hérnia tinham ultrassonografia normal com significância estatística para discordância (p=0,001). Conclusão: a ultrassonografia mostrou-se método não confiável para auxiliar no diagnóstico em casos duvidosos de hérnia inguinal e dispensável quando o diagnóstico era confirmado por queixas típicas e exame físico compatível.
As elasticidades setoriais das exportações brasileiras:uma análise empírica para o período 1999-2013
Authors: Casagrande Dieison Lenon , Feistel Paulo Ricardo , Hidalgo Álvaro Barrantes , Azevedo André Filipe
Published: May 2019

Resumo O objetivo deste estudo é analisar o desempenho das exportações brasileiras de produtos básicos e manufaturados para os blocos de países da Ásia, do NAFTA (Tratado Norte-Americano de Livre Comércio),da União Europeia e do Mercosul (Mercado Comum do Sul) entre os anos de 1999 e 2013. A partir do Modelo de Substitutos Imperfeitos de Goldstein e Khan (1978), foi utilizado o Modelo de Correção de Erros (ECM) para a determinação das elasticidades de curto e de longo prazo. Os resultados obtidos apontam que no comércio com esses blocos de países os produtos básicos são mais sensíveis à renda externa do que para as outras variáveis consideradas. Quanto aos produtos manufaturados, os resultados apontam maior sensibilização à variável renda, exceto para o bloco de países da Ásia, onde a variável preço relativo parece ser o determinante mais importante e que as suas exportações são mais sensíveis a mudanças na taxa de câmbio do que as exportações de produtos básicos.
Desenvolvimento, sofisticação produtiva, valor-trabalho e salários
Authors: Bresser-Pereira Luiz Carlos
Published: May 2019

Resumo Este trabalho discute o conceito histórico (não o normativo) do desenvolvimento econômico, distingue-o de desenvolvimento humano, reafirma sua identificação com industrialização ou mudança estrutural ou sofisticação produtiva; argumenta que o aumento dos salários faz parte integrante do conceito de crescimento e oferece três explicações para isso: (a) os salários são parte da demanda efetiva, (b) os salários podem aumentar com a produtividade, enquanto a taxa de lucro tende a ser constante no longo prazo, (c) e no processo de crescimento, o valor-trabalho do trabalho aumenta porque o custo social da reprodução do trabalho se eleva à medida que aumentam a sofisticação produtiva e a necessidade de educação e treinamento dos trabalhadores e dos tecnoburocratas; afirma que o aumento da produtividade do trabalho devido à transferência de mão de obra de setor de baixo valor adicionado per capita para de alto valor adicionado é mais importante do que o seu aumento no mesmo setor. Finalmente, argumenta que as relações entre crescimento e distribuição, bem como entre crescimento e proteção do meio ambiente, são mais positivas do que negativas.
Produção e emprego industrial nos estados brasileiros: evidências de desindustrialização
Authors: Souza Iago Emidio Lutz de , Veríssimo Michele Polline
Published: May 2019

Resumo Este artigo investiga a hipótese de desindustrialização nos estados brasileiros no período 1996-2014 e se o processo está atrelado às políticas econômicas (taxa de juros e abertura comercial) implementadas no país e ao contexto cambial e de preços favoráveis aos produtos primários. Para isso, analisa indicadores de produção e de emprego da indústria de transformação dos estados e estima modelos com dados em painel. Em síntese, os indicadores de desempenho industrial sinalizam um possível processo de desindustrialização em curso para alguns estados. Ademais, os resultados econométricos sugerem a relevância do contexto cambial e dos preços das commodities para explicar a menor capacidade da indústria de transformação estadual em gerar produto e emprego, evidenciando a hipótese de desindustrialização via doença holandesa.
As mudanças nas formas de gestão escolar no contexto da nova gestão pública no Brasil e em Portugal
Authors: Oliveira Regina Tereza Cestari de
Published: May 2019

RESUMO O artigo tem como objetivo analisar, no contexto de redefinição do papel do Estado, as mudanças nas formas de gestão escolar que foram sendo incorporadas na legislação educacional no Brasil e em Portugal, nas últimas décadas. São países com trajetórias distintas quanto à função do Estado na garantia do direito à educação, às políticas de democratização da educação e à institucionalização da gestão democrática nas escolas, no entanto são países que experimentaram longos períodos de regimes autoritários. A investigação apoia-se na literatura nacional e internacional sobre o tema e em fontes documentais, tomando-se como referência a Lei de Diretrizes e Bases da Educação Nacional (LDB) de 1996, no Brasil, e a Lei de Bases do Sistema Educativo (LBSE) de 1986, em Portugal. O pressuposto é que essas mudanças nos normativos legais provocam uma ruptura no princípio da gestão democrática instituído na Constituição da República Federativa do Brasil de 1988 e na Constituição da República Portuguesa de 1976, com a ascensão de um modelo de gestão escolar centrado na eficácia e na eficiência, com fundamento na Nova Gestão Pública.
História, historiografia e pesquisa em educação histórica
Authors: Martins Estevão C. de Rezende
Published: May 2019

RESUMO O pensamento histórico, cuja articulação produz a consciência histórica, conduz todo agente racional humano a produzir sobre si e sobre seu meio ambiente uma narrativa histórica, fator de identidade (própria e social) e feitora de cultura. A cultura histórica como meio ambiente intelectual envolvente da educação histórica esteia-se, ao menos desde a cientificização da História a partir de meados do século 19, em dois pilares: a narrativa histórica em geral e a narrativa historiográfica em particular. A relevância para a pesquisa em educação histórica da interação e do diálogo entre essas narrativas e de sua interdependência é argumentada neste artigo.