bluuebunny/crossref_metadata_2025 huggingface dataset:
FEATURES OF CHANGES IN CHEMICAL COMPOSITION OF DRINKING WATER AS A RESULT OF WATER TREATMENT (LOVOZERO, KOLA PENINSULA)
Authors: Mazukhina Svetlana I. , Drogobuzhskaya Svetlana V. , Sandimirov Sergey S. , Masloboev Vladimir A.
Published: November 2023

Link for citation: Mazukhina S.I., Drogobuzhskaya S.V., Sandimirov S.S., Masloboev V.A. Features of changes in chemical composition of drinking water as a result of water treatment (Lovozero, Kola Peninsula). Bulletin of the Tomsk Polytechnic University. Geo Аssets Engineering, 2023, vol. 334, no. 10, рр. 243-253. In Rus.
The relevance. Waste water and drinking water treatment is an important and relevant environmental problem faced by the industry. The analysis of scientific literature makes it possible to conclude that it is necessary to apply the methods of water purification and disposal or to develop a scheme for each specific water body, taking into account its physico-chemical characteristics and ionic composition. It is believed that the reagents introduced during water treatment do not change its chemical composition. However, lack of an extended chemical analysis casts doubt on water chemical composition immutability. The main aim of this work is to assess changes in the chemical composition of drinking water supply in Lovozero village (Murmansk region) as a result of water treatment using physico-chemical modeling (PC «Selector»). Objects of the research are samples of the waters of the Virma river and drinking waters of the central water supply (canteen, column) of Lovozero village, selected in November 2021. Methods: inductively coupled plasma mass spectrometry (ELAN 9000 DRC-e, Perkin Elmer, USA), potentiometry (Expert-001, Russia) and titrimetry. Thermodynamic calculations were performed using the method of physico-chemical (thermodynamic) modeling implemented in the software package (PC «Selector»). Results. With the help of monitoring and physico-chemical modeling (PC «Selector») of natural waters of the Virma river and the waters of the central water supply (Lovozero village, Murmansk region), the influence of reagents used as a result of water treatment on water chemistry is assessed. The paper shows the change in pH, Eh values, water chemical composition, newly formed phases composition, depending on the amount of reagents (coagulant, liquid chlorine, soda and sodium hypochlorite (NaOCl). The formation of cations and anions of rare-earth elements at different concentrations of liquid chlorine indicates the possibility of creating a selective method of water purification from rare-earth elements on sorbents of different types or using these properties in ore enrichment. The replacement of reagents with NaOCl solid salt simplifies water treatment, but does not bring water chemical composition closer to that of bottled water and does not make it more useful for macro components.
DETERMINATION OF OPTIMAL OBSERVATION NETWORK PARAMETERS FOR MAPPING PALEOCHANNEL BY THE ELECTRICAL RESISTIVITY TOMOGRAPHY METHOD BASED ON NUMERICAL AND PHYSICAL MODELING
Authors: Osipova Polina S. , Olenchenko Vladimir V. , Chekryzhov Andrey V.
Published: November 2023

Link for citation: Osipova P.S., Olenchenko V.V., Chekryzhov A.V. Determination of optimal observation network parameters for mapping paleochannel by the electrical resistivity tomography method based on numerical and physical modeling. Bulletin of the Tomsk Polytechnic University. Geo Аssets Engineering, 2023, vol. 334, no. 10, рр. 232-242. In Rus.
The relevance of the study is explained by the need to determine the methodological features of applying the electrical resistivity tomography method to map paleochannels when prospecting for placer gold. The main aim: to determine the necessary and enough parameters of the observation network for paleochannel mapping based on numerical and physical modeling. Object: electrical fields on the physical and numerical model of the paleochannel. Methods: electrical resistivity tomography, physical experiment, numerical simulation. Results. Electrical soundings by electrical tomography were carried out on a physical model of a river valley. In addition, a numerical experiment was performed on a three-dimensional model of a river valley fragment with a paleochannel. The unit of the survey scale is the distance between two electrodes, which in the experiment is 1 cm and is equivalent to 5 m in real field studies. The distance between the profiles varied from 2 to 12 cm with a step of 2 cm, which corresponds to different survey scales. In accordance with geological concepts, the authors formed a model of a river valley with a segmentally gently stage of channel formation. Three-dimensional inversion was carried out for the data set obtained at the maximum density of the observation network, and then for the data sparse to the desired scale. On the resistivity map, the paleochannel is recognized by a ribbon-shaped high-resistivity anomaly. The analysis of the maps showed that to determine the shape of the paleochannel in plan, it is necessary to use the observation network scale of 1:3000, at which the distance between the profiles is 30 m. The physical experiment results were confirmed by mathematical modeling. The scale should be reduced to 1:5000 with detailing in individual areas to improve the economic efficiency of geophysical research.
SECONDARY RESOURCES IN PRODUCTION OF COMPOSITE BUILDING MATERIALS BASED ON CEMENT
Authors: Kopanitsa Natalya O. , Demyanenko Olga V. , Kulikova Anzhelika A. , Tkach Evgenia V. , Shestakov Nikolai I. , Stepina Irina V.
Published: November 2023

Link for citation: Kopanitsa N.O., Demyanenko O.V., Kulikova A.A., Tkach E.V., Shestakov N.I., Stepina I.V. Secondary resources in production of composite building materials based on cement. Bulletin of the Tomsk Polytechnic University. Geo Аssets Engineering, 2023, vol. 334, no. 10, рр. 49-60. In Rus.
The relevance of the research is caused by the importance of the problem of rational use of natural resources in production of composite building materials. The possibility of partial replacement of natural non-renewable raw materials used in the production of multi-ton concrete and mortar mixtures based on cement with secondary products from the production of various industries will solve the problems of: resource saving, energy consumption and ecology. The construction industry is the largest consumer of by-products of mining enterprises: overburden and waste from mining and processing enterprises, which is hundreds of millions of tons per year. The most studied are the issues related to their use as fine and coarse aggregates in concrete and mortar mixtures for various purposes. The expansion of the possibility of using secondary products of mining enterprises in the production of composite building materials is associated with the production of active mineral additives, fillers in concrete and mortar mixtures, as well as energetically active nanomodifiers. The use of by-products of different chemical composition and dispersion makes it possible to control the processes of structure formation and hardening of composite materials based on cement and to obtain composite materials with the required performance properties. The main goal of the research is to scientifically substantiate and investigate the possibility of using waste from mining enterprises as components in concrete and mortar mixtures based on cement. Objects: modifying additives based on secondary products; composite materials with enhanced performance properties. Methods: determination of the mobility of mixtures, normal density, hardening time, flexural and compressive strength according to SS; thermal analysis; electron microscopy, x-ray phase analysis, colorimetry. Results. The paper introduces the results of studies necessary for the scientific substantiation, development and implementation in the construction industry of the technology for production of building mortar mixtures obtained using secondary products of mining enterprises as well as the comparative results of studies on the effect of a complex additive of microcalcite and nano-SiO2 on the properties of cement systems. It is shown that the introduction of a complex additive increases the compressive strength of cement stone, reduces the consumption of cement without reducing its standard characteristics and improves the performance properties of concrete.
ЭКОЛОГИЧЕСКИЙ РЕИНЖИНИРИНГ НА ПРЕДПРИЯТИЯХ СРЕДНЕГО УРАЛА: СПЕЦИФИКА СТАРОПРОМЫШЛЕННОГО РЕГИОНА
Authors: Стожко Наталия Юрьевна
Published: November 2023

Актуальность: в настоящее время, в условиях глобального экологического и экономического кризиса, особенно острой становится экологическая ситуация, складывающаяся в старопромышленных регионах (районах) страны. В силу высокой степени износа основных фондов промышленных предприятий и общего накопительного эффекта от загрязнения природной среды на протяжении десятилетий многие территории оказываются непригодными и опасными для проживания населения. В связи с этим главным субъектам хозяйственной деятельности – промышленным предприятиям таких регионов − предстоит экологическая модернизация своих производств. Тем самым экологический реинжиниринг становится средством, с помощью которого такая экологическая безопасность может быть обеспечена. Цель: на основе мониторинга экологической ситуации Уральского старопромышленного региона раскрыть ее специфику и определить основные направления и способы проведения экологического реинжиниринга. Методы: теоретические методы исследования (анализ фактических данных, синтез, обобщение), программно-целевой метод, контент-анализ. Результаты: выявлены особенности экологического состояния Уральского старопромышленного региона; определены перспективы использования «зеленых» технологий в экологическом реинжиниринге промышленных предприятий; сформулированы рекомендации в области развития экологического страхования, совершенствования экологической отчетности и экологической политики промышленных предприятий. Выводы: эффективное регулирование экологических рисков и экологической ситуации в старопромышленном регионе должно учитывать его специфику и строиться на превентивных и стимулирующих способах влияния, среди которых особое значение приобретают организационные изменения в осуществлении экологической политики самих хозяйствующих субъектов. В силу очевидного дефицита эффективных экономических инструментов регулирования экологической ситуации и их репрессивного характера осуществление экологического реинжиниринга на предприятиях и связанный с этим пересмотр приоритетных направлений внутреннего финансирования (самофинансирования), а также развитие системы обязательного экологического страхования обеспечат необходимые условия для перестройки всей экологической (природоохранной) работы хозяйствующих субъектов.
Tracking Racialized Gentrification-Induced Displacement of Indigenous African American Residents
Authors: Lee Eric P.
Published: November 2023

The disproportionate racial impact of gentrification-induced displacement is becoming more of a topic of debate because of the growing evidence and continued outcry of institutional and systemic racism from communities of color. The lack of research in tracking displacement requires new approaches to studying gentrification to address the challenges of investigating the impact on communities of color. In addition to studying the economic, political, and socially motivated reasons for gentrification, the application of a racism-centered framework can shed light on the role of white hegemony in community and urban development policies and practices. Social work researchers can significantly contribute to the body of literature regarding the impact of gentrification-induced displacement of African American residents by applying one of the many social work frameworks in research. Understanding the disproportionate racial impact of displacement on indigenous residents can inform social policies regarding community development strategies and propose interventions to mitigate the impact.
Moods, Emotions, and Engagement in a Music Ensemble Course: A Mixed Method Study with Brazilian Undergraduate Students
Authors: Toni Anderson
Published: November 2023

This study explores the self-reported perception of moods, emotions, and engagement of Brazilian undergraduate students enrolled in a music ensemble course. A mixed method approach was used through a convergent design. Sixteen Brazilian undergraduate students enrolled in a music ensemble course participated in this research. The Present Mood States List (PMSL) was used as a quantitative data collection instrument before and after 15 encounters (14 classes and a final concert). Analysis of quantitative data showed that 15 differences in the mood state values were statistically significant when considering all encounters and 22 differences were statistically significant in specific encounters. The qualitative data collection procedures were (1) the application of a questionnaire on emotions and musical engagement after each encounter and (2) a semi-structured group interview carried out after the fourteenth class. The qualitative data were grouped into four categories: didactics, music repertoire, moods, and data collection. According to the results, participants presented mostly positive mood states and emotions both before and after the encounters. In general, the students’ mood states and emotions seemed to influence their musical engagement, and, at the same time, their sense of musical engagement seemed to influence the presence of positive experiences.
High-Precision Temperature Compensation Method for Downhole Pressure Sensors in Oil and Gas Wells Based on the C-I-WOA-BP Neural Network
Authors: Wang Fei , Zhang Xing , Gao Guowang , Li Xintong , He Xuzhi
Published: November 2023

The Internet of Things (IoT) aims to connect all objects and facilitate data interchange, with data accuracy being paramount. While IoT has seen extensive adoption in conventional sectors, its application in the petroleum industry, especially with downhole equipment, poses challenges due to the extreme high-temperature and high-pressure conditions, making accurate measurements elusive. This Paper we aim to enhance the accuracy of downhole pressure measurements in slim-hole drilling parameter monitoring, mitigate the temperature influences on strain gauges, and surmount the intrinsic limitations of the traditional BP neural network, such as sluggish convergence speeds, high sensitivity to initial weights and biases, unstable learning rates, and a tendency to fall into local minima. This study introduces a temperature compensation model using a chaotic-initiated adaptive whale optimization algorithm (C-I-WOA) to optimize a BP neural network, which is henceforth referred to as the C-I-WOA-BP model. Initially, we harnessed chaotic mapping techniques to refine the initialization process of the whale optimization algorithm (WOA) population, thereby bolstering the heterogeneity of the algorithm. Subsequently, we integrated an adaptive weight recalibration mechanism, refined the encompassing methodology of the WOA, and bolstered its capabilities for expansive global scouting and meticulous local refinement in the solution arena. Subsequently, the WOA was used to optimize the weight coefficients of the BP neural network. Finally, we conducted a detailed comparative analysis by juxtaposing the performance metrics of the BP, C-WOA-BP, I-WOA-BP, and C-I-WOA-BP networks. The experimental results indicate that the C-I-WOA-BP model demonstrates faster convergence speed, superior global search capabilities, and enhanced local exploitation potential compared to the other models. Additionally, it provides a more stable and accurate reduction in temperature-induced errors in drilling pressure parameter measurements.
An Updated Review of Fossil Pollen Evidence for the Study of the Origin, Evolution and Diversification of Caribbean Mangroves
Authors: Rull Valentí
Published: November 2023

Recently, the evolutionary history of the Caribbean mangroves has been reconsidered using partial palynological databases organized by the time intervals of interest, namely Late Cretaceous to Eocene for the origin, Eocene-Oligocene transition for major turnover and Neogene to Quaternary for diversification. These discussions have been published in a set of sequential papers but the raw information remains unknown. This paper reviews all the information available and provides the first comprehensive and updated compilation of the abovementioned partial databases. This compilation is called CARMA-F (CARibbean MAngroves-Fossil) and includes nearly 90 localities from the present and past Caribbean coasts, ranging from the Late Cretaceous to the Pliocene. Details on the Quaternary localities (CARMA-Q) will be published later. CARMA-F lists and illustrates the fossil pollen from past mangrove taxa and their extant representatives, and includes a map of the studied localities and a conventional spreadsheet with the raw data. The compilation is the most complete available for the study of the origin, evolution and diversification of Caribbean mangroves, and is open to modifications for adapting it to the particular interests of each researcher.
Current Status of Nanomedicine in CNS Cancer Therapeutics in the Post-COVID-19 Era
Authors: aventurato Is
Published: November 2023

Central Nervous System (CNS) cancers pose a formidable challenge in the medical world, characterized by aggressive behaviors and limited therapeutic options. The emergence of nanomedicine has offered new hope in CNS cancer treatment. The COVID-19 pandemic has further accelerated the need for innovative therapeutic strategies, emphasizing the significance of nanomedicine in this era. This mini review explores the current status of nanomedicine in CNS cancer therapy, with a particular focus on the post-COVID-19 landscape. We discuss the unique challenges presented by CNS cancers, the potential of nanomedicine in overcoming these challenges, and the recent developments in the field. Additionally, we highlight the lessons learned from the pandemic and how they can be applied to improve CNS cancer therapeutics. We also shed light on the evolving regulatory landscape and the prospects of personalized nanomedicine in CNS cancer treatment. The integration of nanomedicine in CNS cancer therapy is becoming increasingly promising, and its role in the post-COVID-19 era is poised to shape the future of neuro-oncology.
Pengaruh Penggunaan Media Pembelajaran Quizziz Terhadap Kemampuan Membaca Pemahaman dan Minat Membaca Siswa Kelas V Sekolah Dasar
Authors: Eminarti Eminarti , Sulfasyah Sulfasyah , Rahmawati Rahmawati
Published: November 2023

Penelitian ini bertujuan untuk menganalisis pengaruh penggunaan media pembelajaran Quizizz terhadap kemampuan dan minat membaca pemahaman siswa kelas V secara parsial dan simultan. Jenis penelitian ini merupakan penelitian eksperimen semu dengan menggunakan desain non-equivalent control group. Populasi penelitian ini menggunakan seluruh siswa kelas V SD Gugus IV Makassar. Pengambilan sampel menggunakan teknik purposive sampling sehingga diperoleh sampel penelitian yaitu siswa kelas V SD Inpres Galangan Kapal I sebagai kelas eksperimen yang berjumlah 28 siswa dan seluruh siswa kelas V SD Inpres Galangan Kapal III sebagai kelas kontrol yang berjumlah 28 siswa. Instrumen penelitian berupa tes pemahaman bacaan dan angket minat baca. Data dianalisis menggunakan analisis statistik deskriptif dan statistik inferensial menggunakan aplikasi olah data IBM SPSS 25. Hasil analisis deskriptif menunjukkan bahwa kemampuan membaca pemahaman dan minat membaca siswa meningkat melalui penggunaan media pembelajaran Quizizz, dengan N Gain-score masing-masing sebesar 66,12%, dan 67% dengan kategori sedang. Pengujian hipotesis baik secara parsial maupun simultan menerima hipotesis alternatif. Berdasarkan sejumlah hasil analsis dapat disimpulkan bahwa penggunaan media pembelajaran Quizizz.
Persepsi Siswa terhadap Keefektifan Pembelajaran Daring Ditinjau dari Hasil Belajar Siswa Kelas IVA di SD Muhammadiyah 1 Purworejo Tahun Ajaran 2021/2022
Authors: Karuniawati Rahmah , Rokhmaniyah Rokhmaniyah , Suhartono Suhartono
Published: November 2023

Keefektifan pembelajaran daring dapat dilihat selama pembelajaran berlangsung, sikap siswa, penguasaan siswa terhadap materi, dan hasil belajar siswa. Keefektifan tersebut dapat diketahui dari sudut pandang atau persepsi siswa. Tujuan dari penelitian ini adalah untuk mendeskripsikan persepsi siswa terhadap keefektifan pembelajaran daring, menganalisis masalah yang dijumpai, dan menguraikan alternatif solusi untuk mengatasi masalah. Penelitian ini menggunakan triangulasi teknik dengan FGD, wawancara, dan analisis dokumen. Hasil penelitian menunjukkan bahwa persepsi siswa terhadap pelaksanaan pembelajaran daring belum efektif (ditunjukkan dari hasil belajar siswa). Masalah yang dijumpai yaitu: a) keterbatasan perangkat pembelajaran siswa, b) keterbatasan siswa dalam menerima materi pembelajaran, c) kenyamanan selama pembelajaran daring, dan d) tidak ada yang mengontrol kegiatan belajar siswa di rumah. Alternatif solusi yang dilakukan untuk mengatasi masalah-masalah yang ada meliputi: a) melaksanakan pembelajaran daring dengan waktu yang fleksibel, b) melakukan belajar secara mandiri atau les di luar sekolah, dan c) guru membuat grup bersama dengan orang tua siswa. Simpulan dari penelitian ini yaitu menurut siswa kelas IVA pembelajaran daring yang dilaksanakan belum efektif, hanya ada 39,67% siswa yang mendapatkan nilai di atas KKM.
Analisis Perilaku Sosial dan Emosional Siswa terhadap Pelaksanaan Pembelajaran Daring pada Siswa Kelas V SD Negeri 2 Klirong Tahun Ajaran 2021/2022
Authors: Ayuningtyas Widya Ayuningtyas , Suryandari Kartika Chrysti , Wahyudi Wahyudi
Published: November 2023

Perilaku sosial dan emosional memiliki kedudukan yang berpengaruh dalam perkembangan kognitif siswa. Tujuan penelitian ini yaitu: (1) menganalisis perilaku sosial siswa kelas V terhadap pelaksanaan pembelajaran daring; (2) menganalisis perilaku emosional siswa kelas V terhadap pelaksanaan pembelajaran daring. Metode yang digunakan dalam penelitian ini adalah kualitatif dengan pendekatan studi kasus. Teknik pengumpulan data melalui wawancara dan angket, diperkuat dengan pendapat peneliti melalui observasi terkait perilaku sosial dan emosional siswa kelas V dalam pembelajaran daring. Teknis analisis data pada penelitian ini yaitu reduksi data, penyajian data, dan verifikasi. Hasil penelitian ini menunjukan bahwa pada perilaku sosial siswa kelas V terhadap pelaksanaan pembelajaran daring meliputi: siswa mampu berinteraksi dengan guru dan teman, mampu menunjukan sikap interaktif ketika berdialog dengan orang lain melalui WhatsApp, mampu beradaptasi dengan perkembangan teknologi, mampu menunjukan sikap komunikatif, dan mampu menunjukan sikap kerjasama dengan tanggungjawab; pada perilaku emosional siswa kelas V terhadap pelaksanaan pembelajaran daring meliputi mampu menghibur teman yang sedih, menjaga lingkungan sekitar, menaati peraturan pembelajaran daring, menyesuaikan diri dengan kondisi dan situasi pembelajaran daring, mencari sumber belajar sendiri, memahami intruksi yang diberikan guru saat pembelajaran daring, dan menerapkan sikap hormat kepada orang lain.
Penerapan Model Quantum Teaching untuk Meningkatkan Hasil Belajar SBdP Materi Gambar Dekoratif pada Siswa Kelas III SDN Kembaran Tahun Ajaran 2021/2022
Authors: Windasari Desti Maya , Susiani Tri Saptuti , Wahyudi Wahyudi
Published: November 2023

Tujuan penelitian ini yaitu (1) mendeskripsikan langkah-langkah pada penerapan model Quantum Teaching untuk meningkatkan hasil belajar SBdP materi gambar dekoratif, (2) meningkatkan penerapan model Quantum Teaching untuk meningkatkan hasil belajar SBdP materi gambar dekoratif, (3) mendeskripsikan kendala dan solusi dalam penerapan model Quantum Teaching untuk meningkatkan hasil belajar SBdP materi gambar dekoratif. Penelitian tindakan kelas dilaksanakan tiga siklus. Subjek penelitian adalah siswa kelas III SDN Kembaran dengan jumlah 27 siswa. Data yang digunakan berupa data kualitatif dan kuantitatif. Sumber data dalam penelitian adalah siswa dan guru. Teknik pengumpulan data yang digunakan adalah observasi, wawancara, dan tes. Validitas data menggunakan triangulasi sumber dan teknik. Analisis data dilaksanakan melalui reduksi data, penyajian data dan penarikan kesimpulan. Hasil observasi guru siklus I = 86,39%, siklus II = 90,14%, siklus III = 92,78%. Hasil observasi siswa siklus I = 87,50%, siklus II = 91,25%, siklus III = 92,50%. Hasil belajar siklus I = 87,04%, siklus II = 90,74%, dan siklus III = 96,30%. Dapat disimpulkan bahwa penerapan model Quantum Teaching dapat meningkatkan pembelajaran SBdP materi gambar dekoratif pada siswa kelas III SDN Kembaran Tahun Ajaran 2021/2022.
Penerapan Model Problem Based Learning Moda Blended Learning Pada Pembelajaran Tematik Untuk Meningkatkan Hasil Belajar Siswa Sekolah Dasar
Authors: Indrapangastuti Dewi , Wahyudi Achmad Basari Eko , Wahyono Wahyono
Published: November 2023

Penelitian ini bertujuan untuk mengetahui pelaksanaan dan peningkatan hasil belajar pada pembelajaran tematik melalui penerapan model problem based learning moda blended learning pada siswa kelas VI SDN Wirogaten Kebumen tahun ajaran 2022/2023. Penelitian ini merupakan penelitian tindakan kelas dengan subyek penelitian berjumlah 37 siswa. Penelitian ini terdiri dari dua siklus dengan masing-masing siklus terdiri dari 2 kali pertemuan. Instrumen yang digunakan berupa lembar observasi, lembar angket, dan tes. Teknik analisis data menggunakan deskriptif kualitatif. Hasil penelitian menunjukkan bahwa: (1) pelaksanaan pembelajaran dapat terlaksana dengan baik; hal ini dibuktikan dengan data hasil pengamatan pembelajaran pada siklus 1 dan 2 bernilai baik, yaitu modus 4 (baik) dan data hasil tanggapan siswa pada siklus 1 dengan 67,6% setuju, menjadi 81,1% setuju pada siklus 2; dan (2) hasil belajar siswa meningkat dapat dilihat dari rata-rata nilai pos tes siswa pada siklus 1 sebesar 69,05, menjadi 81,24 pada siklus 2.
Analisis Kemampuan Berpikir Kreatif Matematis Dalam Menyelesaikan Open-Ended Problem Siswa Kelas V SD Negeri 4 Kutosari Tahun Ajaran 2019/2020
Authors: Noviana Nicken , Ngatman Ngatman , Hidayah Ratna
Published: November 2023

Penelitian[u1]  ini bertujuan untuk menganalisis proses berpikir kreatif matematis dan tingkat kemampuan berpikir kreatif matematis dalam menyelesaikan open-ended problem siswa kelas V SD Negeri 4 Kutosari. Di era globalisasi ini selain siswa dituntut untuk dapat berpikir kritis namun juga dapatlberpikir kreatif. Melalui berpikir kreatif, siswa mampu memperkayakcara berpikirkdengan alternatif jawaban berbagai ragam dan lebih luas.Metode yang digunakan adalah metode kualitatif dengan menggunakan teknik purposive sampling. Teknis analisis data yang digunakan yaitu reduksi data, penyajian data, dan verifikasi. Subjek penelitian ini adalah guru dan siswa kelas V. Tingkat kemampuan berpikir kreatif matematis akan diambil dari data angket, indikator yang digunakan untuk mengetahui tingkat kemampuan berpikir kreatif matematis tersebut dengan mengamati empat aspek yaitu: kemampuan berpikir lancar (fluency), kemampuan berpikir luwes (flexibility), kemampuan berpikir orisinil (originality), kemampuan terperinci (elaboration). Dari hasil penelitian di kelas V SD Negeri 4 Kutosari diperoleh hasil persentase sebanyak diperoleh hasil persentase sebanyak 44,18% termasuk kedalam TKBK 3i(Kreatif) dan TKBK 2i(Cukup Kreatif),  11,62% termasuk kedalam TKBK 1 (Kurang Kreatif). Namun pada tingkat TKBK 4 (Sangat Kreatif) daniTKBK 0 (Tidak Kreatif) tidak terdapat siswa yang berada pada tingkat tersebut. Berdasarkan simpulanhyang diperoleh dari penelitian ini maka dalam pembelajaran lebih mekankan pada proses penyelesaiannya daripada hasil yang diperoleh. Sehingga pembelajaran akan lebih bermakna dengan adanya pemberian soal open-ended problem.

 [u1]Tambah 1 kalimat mendeskripsikan latar belakang
Peningkatan Kemampuan Berpikir Kritis Siswa Kelas V Melalui Penerapan Model Problem Based Learning Berbantuan LKPD Interaktif
Authors: Sejati Agung Tri Pambudi , Suhartono Suhartono , Suryandari Kartika Crysti
Published: November 2023

Tujuan penelitian ini yaitu mendeskripsikan penerapan model PBL berbantuan LKPD interaktif, meningkatkan kemampuan berpikir kritis siswa tentang suhu dan kalor, dan mendeskripsikan dampak pembelajaran menggunakan model PBL berbantuan LKPD interaktif. Penelitian ini merupakan PTK kolaboratif yang dilaksanakan selama tiga siklus dengan subjek seorang guru dan 28 siswa kelas V SDN Wirogaten Tahun Ajaran 2022/2023. Hasil penelitian ini sebagai berikut. Pertama, penerapan model PBL berbantuan LKPD interaktif adalah mengorientasi masalah, mengorganisasi siswa, mengarahkan siswa dalam penyelidikan, mempresentasikan hasil karya, dan mengevaluasi pemecahan masalah dalam LKPD interaktif. Kedua, penerapan model PBL berbantuan LKPD interaktif dapat meningkatkan kemampuan berpikir kritis siswa terbukti dengan persentase ketuntasan hasil tes kemampuan berpikir kritis pada awal siklus 63% menjadi 86% diakhir siklus. Ketiga, dampak pembelajaran dalam penerapan model PBL berbantuan LKPD interaktif yaitu siswa semakin aktif dan kemampuan berpikir kritisnya meningkat. Kesimpulan penelitian ini yaitu penerapan model PBL berbantuan LKPD interaktif dapat meningkatkan kemampuan berpikir kritis siswa di kelas V SDN Wirogaten  Tahun Ajaran 2022/2023.
Penerapan Model Problem Based Learning Untuk Meningkatkan Keterampilan Proses dan Hasil Belajar IPA pada Siswa Kelas V SDN Ngampel Tahun Ajaran 2022/2023
Authors: Oktaviyanti Melli , Ngatman Ngatman , Suryandari Kartika Chrysti
Published: November 2023

The study aimed to improve process skills and natural science learning outcomes about heat transfer to fifth grade students through the implementation of Problem Based Learning. This class action research was conducted in three cycles. The subjects were teachers and students of fifth grade at SD Negeri Ngampel. The data were qualitative and quantitative. Data collection techniques were observation, interviews, and tests. Data validity used triangulation of source and triangulation of techniques. Data analysis included data reduction, data presentation, and drawing conclusions. Problem Based Learning improved the process skills and natural science learning outcomes. The percentages of process skills were 66.67% in the first cycle, 78.33% in the second cycle, and 86.67% in the third cycle. The passing grades on students' cognitive learning outcomes were 66.67% in the first cycle, 80.95% in the second cycle, and 90.47% in the third cycle. On the students’ scientific attitude, the average percentages were 66.67% in the first cycle, 77.78% in the second cycle, and 86.11% in the third cycle. It concludes that Problem Based Learning improves process skills and natural science learning outcomes to fifth grade students of SDN Ngampel in academic year of 2022/2023
Effectiveness of Non-Pharmaceutical Interventions for COVID-19 in USA
Authors: Liu Yuhang , Wang Weihao , Wong Weng-Kee , Zhu Wei
Published: November 2023

Worldwide, governments imposed non-pharmaceutical interventions (NPIs) during the COVID-19 pandemic to contain the pandemic more effectively. We examined the effectiveness of individual NPIs in the United States during the first wave of the pandemic. Three types of analyses were performed. First, a prototypical Bayesian hierarchical model was employed to gauge the effectiveness of five NPIs and they are gathering restriction, restaurant capacity restriction, business closure, school closure, and stay-at-home order in the 42 states with over 100 deaths by the end of the wave. Second, we examined the effectiveness of the face mask mandate, the sixth and most controversial NPI by counterfactual modeling, which is a variant of the prototypical Bayesian hierarchical model which allows us to answer the question what if the state had imposed the mandate or not. The third analysis used an advanced Bayesian hierarchical model to evaluate the effectiveness of all six NPIs in all 50 states and the District of Columbia, and thus provide a full-scale estimation of the effectiveness of NPIs and the relative effectiveness of each NPI in the entire USA. Our results reinforce earlier results on the general effectiveness of NPIs in arresting the spread of the disease.
Exploring Health Challenges: A Study of Golden Card Holders under PM-JAY in Kashmir
Authors: Mohsin Abdul , Muzaffar Sabahat
Published: November 2023

The Ayushman Bharat Pradhan Mantri Jan Arogya Yojana (AB PM-JAY) stands as a seminal government initiative within the public health landscape of India. Launched in September 2018, AB PM-JAY represents a visionary attempt to address the challenges of healthcare accessibility, affordability, and quality that have long plagued the country. Employing a phenomenological approach, the present research elucidates the complications patients face possessing golden cards in availing healthcare facilities. A purposive sampling technique was utilised to enlist a cohort of 20 seriously ill participants in the Kashmir region. Data acquisition was facilitated through the administration of a semi-structured interview schedule. The ensuing analysis was conducted per Colaizzi's method, yielding two salient thematic constructs: "Fraud and Abuse" and "Issues on Claims Processing and Timeliness." Additionally, a visible distinction between empanelled and un-empanelled healthcare facilities precipitated confusion and a confluence of social, economic, cultural, and psychological adversities for the patients.
Assembly of Interfacial Polyelectrolyte Complexation Fiber Bundles with Mineralization Gradient for Physiologically-inspired Ligament Regeneration
Authors: Wang Tzu-Wei , Liu Yu-Chung , Chen Shih-Heng , Kuan Chen-Hsiang , Chen Shih-Shien , Huang Wei-Yuan , Chen Hao-Xuan , Wu Hsi-Chin
Published: November 2023

Current synthetic grafts for ligament rupture repair often fail to integrate well with the surrounding biological tissue, leading to complications such as graft wear, fatigue, and subsequent re-rupture. To address this medical challenge, this study aims at advancing the development of a biological ligament through the integration of physiologically-inspired principles and tissue engineering strategies. In this study, we utilize interfacial polyelectrolyte complexation spinning technique, along with a custom-designed collection system, to fabricate a hierarchical scaffold mimicking native ligament structure. To emulate the bone-ligament interface and alleviate stress concentration, a hydroxyapatite mineral gradient is strategically introduced near both ends of the scaffold to enhance interface integration and diminish the risk of avulsion rupture. Biomimetic viscoelasticity is successfully displayed to provide similar mechanical support to native ligamentous tissue under physiological conditions. By introducing the connective tissue growth factor and conducting mesenchymal stem cells transplantation, we significantly amplify the regenerative potential of the synthetic ligament. This pioneering study offers a multifaceted solution combining biomimetic materials, regenerative therapies, and advanced techniques to potentially transform ligament rupture treatment.
Challenges and Solutions to Banning the Advertisement of Unhealthy Products: A Qualitative Study
Authors: Najafi Marziyeh , Mosadeghrad Ali Mohammad , Arab Mohammad
Published: November 2023

Unhealthy products (food, alcohol, tobacco) are among the main risk factors of non-communicable diseases. To discourage the consumption of these products, Iran has passed a law banning the advertisement of unhealthy products in all media and for all age groups. The purpose of the present study was to identify the challenges of this approach and provide evidence to facilitate the enforcement process and the participation of stakeholders. In this qualitative study participants were selected from the policymakers and experts involved in the banning of advertisements on unhealthy products in Iran. Semi-structured interviews were conducted with 24 specialists and experts. The participants were selected through purposive and snowball sampling. Identified challenges and solutions were divided into three categories and nine themes: external (political, social, and economic); interorganizational (mission and communication); and internal (planning, organization, leadership, and control). Banning the advertisement of unhealthy products involves many challenges due to the existence of key players with different roles and missions. If these challenges are not managed effectively, they will hinder the enforcement and success of this law. Therefore, it is necessary for policymakers and health system managers to take the necessary measures to remove these obstacles.
GWAS identifies genetic clusters of cardiometabolic risk factors in continental Africans
Authors: Fatumo Segun , Machipisa Tafazwa , Diawara Abdoulaye , Nakabuye Mariam , Soremekun Opeyemi , Toure Sounkou , Kamiza Abram , Wele Mamadou , Nashiru Oyekanmi , Pirie Fraser , Asimit Jennifer , Motala Ayesha , Chikowore Tinashe
Published: November 2023

Cardiometabolic risk factors (CMRFs) are a growing global health concern. Here, we set out to identify novel genetic loci associated with CMRFs in two continental African populations, Ugandans and South African Zulu’s. Thus, we conducted a multivariate meta-analysis with META-SCOPA; where six CMRFs comprising of waist circumference (WC), triglycerides (TG), high-density lipoprotein (HDL), systolic blood pressure (SBP), diastolic blood pressure (DBP), and glycated hemoglobin A1c (HbA1c) were used. META-SCOPA identified five novel loci and its Multi-marker Analysis of GenoMic Annotation (MAGMA) gene-set analysis showed an association with human histone acetyltransferase/male sex-lethal (MSL) complex. Fine-mapping, colocalization, tissue expression analyses, and phenome-wide association study (PheWAS) were also implemented to better understand the meta-analysis findings. Furthermore, as a supplement a principal component analysis (PCA) GWAS was also performed on the same six CMRFs. The first principal component denoted cardiometabolic_PC1 was driven mostly by DBP and SBP. Five novel, significant loci were identified after the meta-analysis. Ultimately, our novel loci and gene-sets offer fresh insights into the clustering of CMRFs and propose a unique link to the human histone acetyltransferase/MSL complex, as well as circulatory system processes in continental Africans. Additional large-scale efforts in Africa are needed to understand the clustering of CMRFs.
Classification of laryngeal diseases including laryngeal cancer, benign mucosal disease, and vocal cord paralysis by artificial intelligence using voice analysis
Authors: Kim Hyun-Bum , Song Jaemin , Park Seho , Lee Yong Oh
Published: November 2023

Voice change is often the first sign of laryngeal cancer, leading to diagnosis through hospital laryngoscopy. Screening for laryngeal cancer solely based on voice could enhance early detection. However, identifying voice indicators specific to laryngeal cancer is challenging, especially when differentiating it from other laryngeal ailments. This study presents an artificial intelligence model designed to distinguish between healthy voices, laryngeal cancer voices, and those of the other laryngeal conditions. We gathered voice samples of individuals with laryngeal cancer, vocal cord paralysis, benign mucosal diseases, and healthy participants. Comprehensive testing was conducted to determine the best mel-frequency cepstral coefficient conversion and machine learning techniques, with results analyzed in-depth. In our tests, laryngeal diseases distinguishing from healthy voices achieved an accuracy of 0.85 to 0.97. However, when multiclass classification, accuracy ranged from 0.74 to 0.83. These findings highlight the challenges of artificial intelligence-driven voice-based diagnosis due to overlaps with benign conditions but also underscore its potential.
Whole - Genome Sequence Analysis of Carbapenem Resistant Acinetobacter baumannii isolated from Medan, North Sumatera, Indonesia
Authors: Wiranto Edy , Soebandrio Amin , Paramita Rafika Indah , Kusumawati R Lia , Tania Tryna , Mutiara Mutiara , Severin Juli¨ette A.
Published: November 2023

Background
Acinetobacter baumannii, an opportunistic pathogen that is responsible for nosocomial infections globally, presents a formidable challenge owing to its ability to develop resistance against antibiotics. This resistance, which includes resistance to carbapenems, the last-resort antibiotics, has led to the emergence of Carbapenem-Resistant Acinetobacter baumannii (CRAB) strains. The distribution of these strains encompasses Indonesia, particularly in Medan. Investigation on its resistance can only be performed thoroughly using Whole Genome Sequencing (WGS) process.
Methods
The samples used in this study is 32 bacterial isolates from Murni Teguh Memorial Hospital in Medan, North Sumatra, collected between July – December 2022 and has been confirmed as A. baumannii using VITEK-2 system. Bacterial isolates are tested for carbapenem sensitivity using disc diffusion method. DNA isolation is performed using QIAamp DNA mini kit and ran through WGS process using Novaseq 6000 Illumina. Bioinformatics analysis is performed consisting of MLST, phylogenetic tree, identification of elements such as resistance genes, plasmids, insertion sequences, prophage sequences, and CRISPR/Cas system sequences.
Results
58 resistance genes and several mutations were identified. The majority of these genes exert their influence on resistance through efflux pump mechanisms. All the carbapenem-resistant isolates showing co-occurrence of blaOXA-23 and blaOXA-51 family genes. MLST analysis revealed that out of the 30 isolates, 27 were identified as A. baumannii and were further divided into 7 distinct Sequence Types (STs), with the majority belonging to ST 2 and ST 1. Furthermore, the analysis uncovered the presence of novel STs, specifically assigned as ST-Past 2456 and ST-Oxf 3213. Aside from resistance genes, 20 plasmids, 89 insertion sequences, 20 prophage sequences, and 1 CRISPR/Cas system identified in this research.
Conclusion
WGS analysis of A. baumannii isolates from Medan reveals the presence of several resistance determinants that can contribute to the high resistance levels observed in these isolates. Comparative analysis with global isolates indicates that the majority of isolates belong to globally recognized lineages with high resistance levels. Along with the discovery of the new ST in this study, the information obtained is expected to assist other researchers in further studies related to A. baumannii and its resistance to antimicrobials.
WITHDRAWN: Understanding the signalling pathway of the GnRH receptor: a molecular dynamics study
Authors: Paspali Elpiniki , Kubiak-Ossowska Karina , Ferro Valerie Anne , Mulheran Paul Alexander
Published: November 2023

The signalling mechanism of G-protein coupled receptors has been broadly studied, however, due to their structural complexity, details of the signalling pathway remain unclear. Here we present molecular dynamics (MD) simulations that reveal the conformational changes of the GnRH receptor (GnRH1R) induced by interaction with the gonadotropin-releasing hormone (GnRH). A comparison between the GnRH1R conformation in the absence and presence of GnRH reveals specific conformational differences that characterise an active and inactive state of the receptor. Furthermore, we describe a detailed cascade of ligand-induced conformational changes in the GnRH receptor that can lead to intracellular signal transmission. We observe that following the initial interaction of GnRH, the signal travels via a particular activation switch triad (Glu90-Lys121-Ser124). This acts as the driving force for an intracellular loop to reposition and expose the G-protein orthosteric pocket. In contrast, in the absence of GnRH, the receptor adopts an inactive conformation, where the activation switch residues are separated while the G-protein binding site is sterically blocked. These findings will aid the discovery of new pharmaceuticals targeting GnRH1R, and they broaden understanding of the signal transmission process and hence the functionality of G-protein coupled receptors in general.
Attentional Switching in Larval Zebrafish: The Attentive Leaky Integrator
Authors: Krishnan Kumaresh , Muthukumar Akila , Sterrett Scott , Pflitsch Paula , Fairhall Adrienne , Fishman Mark , Bahl Armin , Zwaka Hanna , Engert Florian
Published: November 2023

Decision making strategies in the face of conflicting or uncertain sensory input have been successfully described by a drift diffusion to bound model (DDM) in many different species. Here we analyze large behavioral datasets of larval zebrafish engaged in a ‘coherent dot’ optomotor assay and compare DDM performance with trial-to-trial variation in our experimental results. We find a clear discrepancy in the low-level structure of modeled and experimental data, which compels us to implement a critical extension to the classic DDM. To correct for the discrepancy, we propose to add an extra variable that explicitly controls the transition between an engaged and a disengaged state. This addition not only accurately captures the lower-level structure in our data, but also provides a framework to explain general behavioral switches between different tasks and contextual priorities. We use these insights to define two behavioral performance metrics for the zebrafish, labeled ‘focus’ and ‘competence’, which describe two orthogonal aspects of performance in a task. We further show that the extent of ‘focus’ is largely inherited from the parents, while ‘competence’ is influenced mainly by environmental context. This quantitative framework for analyzing decision making can be used to screen genetic perturbations for their impact on these two aspects of performance, and eventually help identify a genetic basis, and a neural mechanism for attention, that extends across organisms.
The Clinical Relevance of Different Antiphospholipid Antibody Profiles in Pediatric Rheumatology Patients
Authors: Pandya Jheel , Onel Karen , Erkan Doruk
Published: November 2023

Background: The clinical relevance of different antiphospholipid antibody (aPL) profiles, including low level anticardiolipin (aCL) and anti-β2-glycoprotein-I (aβ2GPI) antibodies, is ill-defined in the pediatric population. Our purpose is to describe the demographic, clinical, and laboratory characteristics of aPL positive pediatric patients based on different aPL profiles.
Findings: In this single center retrospective cohort study, based on the screening of our pediatric (age <18) rheumatology electronic medical records (2016-2022), we identified patients who had at least one “positive” aPL (lupus anticoagulant [LA], aCL IgG/M, or aβ2GPI IgG/M) result. Patients were grouped into high- (LA positive and/or aCL/aβ2GPI IgG/M > 40U [ELISA]) and low-risk (LA negative and aCL/aβ2GPI IgG/M 20-39U) aPL profiles; those with persistently positive aPL were descriptively analyzed for demographic and clinical characteristics.
Of 57 included patients, 34 (59%) had initial high- and 23 (40%) had initial low-risk profiles. Based on subsequent aPL results available in 42/57 (74%) patients, 25/27 (93%) in the high-, and 7/15 (47%) in the low-risk groups remained still positive. Of these 32 patients with persistently positive aPL, moderate-to-large vessel or microvascular thrombosis occurred in nine (28%) patients with high-risk and in none with low-risk aPL profiles; non-thrombotic aPL-related manifestations were reported in 15 (47%) patients with persistent aPL positivity.
Conclusion: An initial high-risk aPL profile was persistent in approximately 90% of our cohort, a third of whom had thrombosis, and half had non-thrombotic aPL manifestations. Our results underscore the need for a large-scale effort to better characterize aPL-related manifestations in pediatric patients with persistent high-risk aPL-profiles.