bluuebunny/crossref_metadata_2025 huggingface dataset:
Predicting Role of Preoperative Computed Tomography Features on Invasiveness of Thymic Neoplasms
Authors: Kumbasar Ulaş , Taydaş Onur , Uysal Serkan , Dikmen Erkan , Yılmaz Mustafa , Demircin Metin , Doğan Rıza , Arıyürek Macit
Published: January 2021

Purpose: The anterior mediastinal masses are composed of neoplasms from many different groups, thymic epithelial tumors (TET) being the most common type. Histologic subtype, tumor stage and completeness of resection are considered to be the most important prognostic factors in thymic malignancies. The aim of this study is to evaluate the association between the preoperative CT characteristics and the histological types, mostly focusing on thymic neoplasms.

Methods: Preoperative CT features and pathologic data of 40 patients who underwent surgery due to an anterior mediastinal mass were retrospectively analyzed. Patients are grouped as thymomas, thymic carcinomas and others.

Results: CT characteristics such as shape, contour, necrosis, lymph node enlargement, surrounding organization, pathologic invasion pattern, internal density, presence of cystic component, pleural/pericardial effusion and calcification were compared with histologic subtypes. Among these parameters solely pathologic invasion and surrounding organization were statistically different between the groups (p<0.001 and p=0.001, respectively). Correlation between the CT and pathologic tumor sizes among histologic subtypes was also analyzed and no statistically significant difference between CT and pathologic tumor sizes was detected (p>0,05).

Conclusion: According to the results of our study, CT imaging has a limited role in predicting stage and malignant potential particularly for thymic neoplasms and anterior mediastinal masses.
Importance of The Medical History in The Diagnosis of Hypersensitivity Pneumonitis: A Case Report
Authors: Ecin Seval Müzeyyen , Sandal Abdulsamet , Koyuncu Adem , Öz Şerife Gül
Published: January 2021

Introduction: Hypersensitivity pneumonitis, most frequent types are those related to farming and bird breeding. In this paper, a patient with occupational exposure to metal dusts and welding fumes but diagnosed with HP thanks to the guidance of detailed anamnesis revealing inhalational exposure to pigeon antigens both at home and in workplace Case: 32-year-old male. He applied with shortness of breath, dry cough. He has been working production of kitchen equipment made from stainless steel. When environmental exposures questioned, he declared that he bred up to ten pigeons at the basement of his house and up to fifteen pigeons at a coop next to workplace building. Spirometry revealed restrictive pattern. In patient’s chest X-ray, bilateral increased reticular densities were observed. Computed tomography of thorax revealed radiological findings supporting subacute hypersensitivity pneumonitis such as bilateral diffuse millimetric centrilobular ground-glass nodules which are coalescing in some areas, mosaic perfusion and air trapping in basal areas. Bronchoalveolar lavage cytology revealed percentages of lymphocytes as 85%. Discussion: Detailed anamnesis revealing environmental and occupational inhalational exposures guides the physician in diagnosis of HP. After initial suspicion, supporting laboratory and radiologic findings confirm the diagnosis to provide appropriate management.
The Way to a More Integrated Territorial State Administration. The Aims and Causes Behind the Renewal of Hungarian Mid-Level State Administration
Authors: Barta Attila
Published: January 2021

This study focuses primarily on the territorial bodies of mid-level state administration. Hungarian territorial state administration has been under constant transformation since 1989–1990. As other studies have already researched the key steps of this transformation extensively, this paper focuses solely on the major developments of the 2016/2017 calendar years (primarily due to the manuscript deadline). The study is mostly based on the analysis of the relevant Hungarian legislation, but also contains an international outlook. In summary, the paper concludes that in recent years the number of Hungarian territorial administrative organisations have been greatly reduced, the importance of the capital and county government offices have been greatly increased, the system of the district-level offices have been differentiated, and the customer relationship solutions have seen a notable renewal. The aforesaid conclusions will also offer a system-level interpretation of this Neo-Weberian Hungarian transformation.
valor del perdón para fomentar la cultura de una sana convivencia en venezuela en el marco de la paz y la vida.
Authors: Chinchilla María
Published: January 2021

La educación en Venezuela exige cada día innovaciones debido a las exigencias y diferencias que se presentan en la sociedad. Al respecto, se presenta el siguiente plan de acción: el valor del perdón  para fomentar la cultura de una sana convivencia en Venezuela en el marco de la paz y la vida, proyecto que se organizó para ser ejecutado en ocho semanas es decir, cuarenta días. Mediante el currículo bolivariano se permite la flexibilidad que se construyan aprendizajes significativos, que van en beneficio de una sociedad. En tal sentido, se plantearon los objetivos de la investigación, entre ellos tenemos: Determinar la importancia de los valores mediante la práctica del perdón como medio para fomentar la cultura de una sana convivencia en Venezuela en el marco de la paz y la vida. La metodología aplicada fue una investigación cualitativa bajo la modalidad de la investigación acción participante según Pérez (1990). Tomando como espacio de estudio la Escuela Nacional, E.B. "Alfredo Pietri" de Boquerón, municipio autónomo Carlos Arvelo del Estado Carabobo, Caracas-Venezuela. Se aplicó la técnica de la observación participante y la entrevista para recolectar los datos, de igual manera como técnica de análisis la categorización y la triangulación. Se llevó un registro de experiencia de los cuarenta días, siendo de impacto en el ámbito escolar, familiar y social.
PengaruhUtangdan PerputaranModalKerjaTerhadapProfitabilitasPerusahaan(Studi Kasus Pada PT Bumi Sekar Tbk Periode 2013-2018)
Authors: Saprudin Saprudin , Hartono Bayu
Published: January 2021

This study aims to determine how much influence the debt, working capital turnover has on the profitability of PT Sekar Bumi Tbk. Debt is proxied by DER, working capital turnover is proxied by WCT, while profitability is proxied by ROA. Based on the nature of the data used in this study is a type of quantitative research. Samples were taken, namely PT Sekar Bumi Tbk with the objectof research of 2013-2018 financial statements. Linear regression analysis was used in this study, with the help of SPSS software for Windows 20.0. The results of this study explain that partially DER has a significant effect on ROA, and has a very strong relationship of 83.9%. WCT has no significant effect on ROA, and has a very weak relationship of 18.4%. However, simultaneously DER and WCT has a significant effect with a contribution of 70.8% to ROA. So companies need to pay attention and consider how much effective the use of debt as a source of funding for the company.
PENINGKATAN KEMAMPUAN ARTIKULASI DAN PENGUASAAN KOSA KATA MELALUI METODE TUTOR SEBAYA PADA SISWA SDLB KELAS TUNARUNGU
Authors: Bajeri Darwina , Waspodo Muktiono , Herawati Herawati
Published: January 2021

Penelitian ini adalah penelitian tindakan kelas (PTK). Subjek penelitian adalah peserta didik Sekolah Dasar dengan hambatan pendengaran di SLB Bina Mandiri Kota Bogor sebanyak 8 siswa. Subjek dalam penelitian ini memiliki hambatan pada pendengaran, hal ini berdampak rendahnya kemampuan artikulasi, dan rendahnya penguasaan kosakata peserta didik.Desain PTK menggunakan model Kemmis dan Taggart yang meliputi tahap perencanaan, pelaksanaan, pengamatan, dan refleksi. Teknik pengumpulan data menggunakan wawancara, observasi dan tes. Instrumen yang digunakan yaitu panduan wawancara, lembar observasi kemampuan artikulasi peserta didik serta tes penguasaan kosakata benda. Teknik analisis yang digunakan yaitu statistik deskripstif kuantitatif dan kualitatif.Hasil penelitian menunjukan adanya perbaikan pada proses pembelajaran Pengembangan Komunikasi Persepsi Bunyi dan Irama yang meningkatan kemampuan artikulasi dan penguasaan kosakata pada peserta didik melalui metode tutor sebaya. Perbaikan proses terlihat dari aktivitas peserta didik sebagai tutor bagi temannya yang kemampuannya lebih rendah, yaitu peserta didik menunjukan perhatian, ketertarikan dan respon yang baik dalam proses pembelajaran. Adapun hasil kemampuan artikulasi dan peguasaan kosakata peserta didik saat pra tindakan yaitu nilai terendah pada  yaitu 22,5, siklus I menjadi 29 dan siklus II menjadi 55, nilai tertinggi pada pra-siklus yaitu 58, siklus I menjadi 68, dan siklus II menjadi 91, dengan nilai rata-rata pada pra-siklus yaitu 37,31 (sangat kurang), siklus I menjadi 50,12(kurang), dan siklus II menjadi 70,25 (baik).
The Gel Soap with Raw Materials of Lerak Fruit (Sapindus rarak DC)
Authors: Wijayanti Fitria , Sari Mayang , Suprayitno Roni , Aminin Dian
Published: January 2021

Lerak (sapindus rarak DC) is one of the plants that is often used as a noble metal washer, facial cleanser as a remover for acne and as an insecticide, especially earthworms. In this study the manufacture of soap gel by using Lerak plants. Lerak fruit (Sapindus rarak DC) is one of the natural ingredients that can be used as an alternative in soap raw materials. Lerak fruit (S. rarak) contains several secondary metabolites. The most dominant secondary metabolite is saponin. These saponins act as raw material for making soap. The purpose of this study is the use of natural materials, especially Lerak fruit as raw material for gel soap Tests conducted on soap are foam test, soap quality with experiments on several stains and organoleptic soap tests. The results obtained Lerak fruit can be used as raw materials for soap. The foam test results on the soap found that the soap foaming durability was longer. The results of soap quality testing on several stains namely charcoal stains, soy sauce stains and sauces prove the soap can clean stains well. The organoleptic results get a distinctive aroma, odor, and average of density are 1.01.
The Sintesis dan Karakterisasi Komposit Fe3O4/Kitosan/Kaolin Bangka
Authors: Julianti Eva , Fabiani Verry Andre , Asriza Ristika Oktavia
Published: January 2021

Sintesis dan karakterisasi komposit Fe3O4/kitosan/kaolin Bangka telah dilakukan. Sintesis komposit dilakukan dengan memvariasikan komposisi kaolin (0; 0,25; 0,5; dan 1 gr). Pada komposisi Fe3O4 95 mg dan kitosan 1 gr. Karakterisasi komposit Fe3O4/kitosan/kaolin dilakukan dengan analisis XRD, FTIR/, uji porositas, derajat pengembangan, dan uji adsorpsi pada ion Cu2+. Hasil analisis XRD menunjukkan adanya puncak difraksi kaolin dan Fe3O4 pada 2θ= 8,92o, 29,57o, dan 45,61o (kaolin) serta 35,64o, dan 45,61o (Fe3O4). Hasil analisis FTIR menunjukkan adanya pita serapan yang khas dari kitosan, kaolin, dan Fe3O4 pada hasil analisis FTIR menunjukkan ada pita serapan pada daerah 3825, 3689, 2103, dan 1425 cm-1 (kitosan), 1028, dan 884,41 cm-1 (kaolin), 791,11 cm-1 (kitosan), dan 696,95 cm-1 (Fe3O4). Nilai porositas tertinggi yaitu 1,547% tanpa penambahan kaolin, derajat pengembangan tertinggi yaitu 754,63 % juga tanpa penambahan kaolin. Uji adsorpsi terhadap ion Cu2+ menunjukkan nilai efisiensi adsorpsi sebesar 72,41% pada penambahan kaolin 1 gr.
Távoktatás másként
Authors: Benedek András
Published: January 2021

Magyarországon a legnagyobb távoktatási hallgatói létszám a Budapesti Műszaki és Gazdaságtudományi Egyetem pedagógus szakirányú továbbképzéséhez kapcsolódik. Jelen írás érzékelteti, hogy a távoktatás iránt elkötelezetteket, a képzés fejlesztőit és szervezőit, milyen váratlanul értek azok a hírek, melyek március elején világszerte jelezték, hogy az oktatási rendszereknek a távolléti oktatásra történő gyors átállás kihívásával kell szembenézniük. Az elmúlt negyed században mintegy 27 ezer hallgató végzett programjainkon, melyeket korszerű oktatási keretrendszerben, kiváló szakmai konzulensekkel, innovatív oktatási formákban és módszerekkel valósítunk meg. Március 10-én az elsők között döntöttünk arról, hogy az online oktatásra történő átállás forgatókönyvét kidolgozzuk, májusban ennek eredményeként az elektronikus keretrendszer alkalmazásával sikeresen szigorlatoztak 44 tankörben 596-an. Június első két hetében pedig eredményesen záróvizsgáztak 375-en, teljesítve mindazon képzési követelményeknek, melyek az adott végzettségek - közoktatási vezető, mentortanár, mérés-értékelés szakértő, mestervezető - szakképesítés megszerzéséhez előírtak. In Hungary, it is the further training in pedagogical specialization at the Budapest University of Technology and Economics that has the highest number of students in distance education. This paper presents how unexpectedly those devoted to distance education, the developers and organizers of the training, were affected by the news that, at the beginning of March, indicated that the education systems had to face the challenges of rapid shift to remote learning all over the world. During the latest 25 years, about 27 thousand students have completed our educational programs that have been implemented in an up-to-date educational framework system, with excellent vocational consultants and using innovative educational forms and methods. On March 10th, we were one of the first to decide about elaborating the schedule of shifting over to online education, and as a result, in May, 596 persons in 44 learning groups successfully took their comprehensive examinations by applying the electronic framework system. During the first two weeks of June, 375 persons took their final exams, meeting all the training requirements that were prescribed to get the relevant qualifications (leader in public education, mentor teacher, expert of measuring and evaluation and master leader).
Tourism and COVID-19: Social and Lateral marketing to the rescue
Authors: Zerva Konstantina
Published: January 2021

The beginning of 2020 has been marked by the COVID-19 pandemic and its socio-economical effect at a global scale. One of the most negatively influenced sectors is tourism since in a time of limited mobility and lock downs, seems unable to continue producing and offering most of its products and services. Traditional marketing is put aside by the need of two particular types of marketing, that is, social marketing and lateral marketing, which call for the behavioral change of the consumer side, and the creative reaction of the production side, respectively. This essay tries to highlight the importance of these strategies in times of crisis.
建筑工程机电设备安装施工中的技术与质量管理
Authors: 邢 春光
Published: January 2021

近年来，我国社会经济在多方面利好因素的影响下，整体水平得到了显著的提升，从而为各个领域的发展壮大带来了诸多的机遇，有效的促进了民众生活水平的快速提升，在这种形势下，人们对生活环境提出了更高的要求。一个完整的建筑工程结构要想切实的满足人们生活、工作、娱乐、学习等多个层面的实际需要，那么最为重要的就是需要合理的运用机电安装施工技术提升整个建筑工程的综合性能。鉴于此，这篇文章主要围绕建筑工程机电设备安装施工中机遇与质量管理工作展开全面深入的研究分析，希望能够对我国建筑工程行业的持续稳定发展有所帮助。
浅谈如何做好农村饮水安全工程的建后运行管理
Authors: 孙 涛
Published: January 2021

水资源是人类赖以生存和发展的重要基础，所以切实的保证水资源的安全性对于推动人类社会稳定持续发展能够起到积极的影响。但是就现如今实际情况来说，在我国一些偏远地区，因为地理环境的问题，使得饮用水安全问题十分的严重。社会的发展带动了人们思想意识的不断进步，人们对于农村安全饮水工程建设工作越发的重视，这样就为农村安全饮水工程提出了更高的要求。全面落实农村安全饮水工程建设工作，能够有效的保证农村地区民众的饮用水的质量。但是在农村饮水安全工程建设工作全面实施的过程中，使得诸多运行和管理工作中所存在的问题越发的凸现出来，部分工程单位对于建设工作十分关注，对于管理工作较为忽视，再加上运行管理专业工作人员数量无法满足工作实际需要，维修保养费用不充足等诸多问题，使得农村饮水安全工程在正式投入使用之后无法将其应有作用切实的发挥出来。针对上述问题，要想切实的加以解决，那么最为重要的就是需要全面的落实运行管理工作，促使工程收益的不断提升。
生态护坡技术在河道治理中的应用研究
Authors: 刘 国霞
Published: January 2021

生态建设已经成为当前城市建设中非常重要的一项内容，社会各界也逐渐加大了对生态环境的关注。在治理河道过程中，护坡建设是非常关键的内容，通常采用砌石方式将河道结构稳定性提升。虽然当前该技术能够将河道结构稳定性提升，但是这不利于河道生态环境的保护，此时，生态护坡技术应运而生。应当在明确生态护坡技术的前提下，就生态护坡技术的应用原则进行总结，并且采取有效的护坡方式。
水利工程施工现场安全管理浅议
Authors: 孙 建乐
Published: January 2021

我国进行水利工程建设，对国民有较大生产、生活意义，水利工程可借助自然界中的地表水、地下水等水系资源，来完成工程建设目标，从而为防洪防涝、农业、工业等渠道取得较高应用成效。水利工程其建设难度较高，为保持其建设中的完整系统性、技术性，建设施工阶段应进行高效的现场安全管理措施，以此来避免质量安全隐患。本文分析水利工程的现场安全管理其应用意义，并结合实际管理案例，提出安全管理各项可行性思考，最终探讨在实际应用中的各项安全管理措施，提升水利工程新时期建设质量。
电力物联网传感器技术在电力设备在线监测中的应用
Authors: 占 建根
Published: January 2021

在社会快速发展的带动下，使得我国科学技术水平得到了显著的提升，促使大量的新型科学技术被人们研发出来，并在实践运用过程中起到了十分重要的影响作用。在当前科学技术飞速发展的形势下，互联网的出现使得人们的工作和生活发生了巨大的变化，为人类社会的稳定健康发展带来了良好的机遇。这篇文章主要针对电力物联网传感器技术在电力设备在线监测工作中的实践运用展开全面深入的研究分析，希望能够对我国综合国力的不断提升起到积极的辅助作用。
基于电力营销抄核收自动化应用的分析
Authors: 范 海明
Published: January 2021

自从电力系统建立后，人民的生活发生了翻天覆地的变化，居民生活水平获得了巨大提高，极大程度上为生活提供了便利。电力系统与其他生产行业是不同的，在对经济发展的影响方面，电力系统更加具有影响力，对国家经济发展有重要的意义。随着科学技术与经济的共同发展，我国建立企业市场也开始向着自动化运营的道路上发展，各种新技术与新手段正在不断进入行业发展中，其中在电力营销抄核收工作方面，许多新技术为其发展做出了巨大贡献。当前我国电力企业的同行竞争情况比较多，并且还有许多亟待解决的行业发展问题，想要打破这种困境，就需要提高对抄核收工作的重视，努力解决当下的问题，逐渐改善不合理的现实问题，提高工作人员自身素质，降低事故发生的可能性，确保电力企业健康良性发展。
配电网三相换相开关换相策略研究
Authors: 顾 栋杰
Published: January 2021

配电网电力负荷的三相不平衡导致了配电网线路损耗、配电变压器寿命下降等问题。在换相开关式、电容器式、电力电子式三种主流的三相不平衡治理方式中，换相开关以其独特的处理方式和特点从而具有很好的处理效果。为了满足换相开关式三相不平衡治理技术的应用可靠性，文章深入研究了三相换相开关的换相技术原理以及深入分析了负载功率因数对于三相换相开关换相策略的影响。提出了一种能够提升和改善三相换相开关运行可靠性的技术方法，从而使其更好的应用于配电网，改善配电网负荷三相不平衡的现状，提升终端用户的用电质量。
水利水电施工中筑坝工程的关键工艺分析
Authors: 阮 对平
Published: January 2021

在社会经济飞速发展的带动下，使得各个领域都得到了全面的发展壮大，从而使得社会发展以及民众的生活对水利水电能源的需求量在不断的增加，这样就对水利水电工程施工工作提出了更高的要求。在科学技术快速发展的带动下，促进了水利水电工程施工技术整体水平得到了显著的提升，为我国社会经济的良好发展起到了积极的辅助作用。在整个水利水电工程结构之中，水石坝施工工作是水利水电工程施工工作中较为重要的一项工作，筑坝施工技术水平往往与工程施工效率和质量存在直接的关联，怎样对施工工艺加以切实的把控，促进工程施工效率的不断提升，从根本上对施工质量加以保证，是确保筑坝工程施工工作实现既定的目标的重要基础。筑坝施工工作对施工技术水平要求相对较高，施工工作具有明显的复杂性，施工技术水平与工程施工质量密切相关，并且也与施工周期和工程成本存在直接的关联。
水利工程水闸施工技术及管理探讨
Authors: 张 敏
Published: January 2021

近年来，在各个行业快速发展的过程中，使得水资源匮乏的问题越发的凸现出来，为了有效的缓解这一问题，各个地区都在积极的建造水利工程项目。在整个水利工程结构中，水闸结构是其中较为重要的一个部分，整个水闸结构包括低压和中压液压部件，利用挡板结构来实现储水和排水的目的。水闸结构最为重要的作用就是对水源进行调解，避免发生严重的水患灾害。建造水利工程能够对我国社会经济的发展起到积极的影响作用，水利工程中水闸施工管理的整体效果往往会与施工质量密切相关。水闸结构的建造在整个水利工程施工工作中的作用是非常巨大的，在实际开展水闸施工管理工作的时候，需要综合实际施工情况来编制工程施工方案，从各个细节入手来保证工程整体施工质量。
Drama-in-Education for Critical Historical Thinkers: A Case Study in the Greek Context
Authors: Kosti Katerina , Papaioannou Theodora
Published: January 2021

The case study presented in this article refers to the connection of drama-in-education and critical thinking in history, in order to highlight the importance of drama for the teaching of history in primary schools in Greece. The research plan adopted is quantitative and qualitative, and the research strategy applied is that of case study. For the purposes of this study, four scenarios based on drama-in-education techniques were designed and applied on a sample of forty-three primary students. The analysis of the findings show that the students’ understanding of historical contexts and objectives of historically active subjects was encouraged by drama-based instruction.
The Public Procurement and the Quality of Services: The Case of Moscow Hospitals
Authors: Kravtsova Margarita  V.
Published: January 2021

The work is devoted to the search for answers to the question: “Are there any differences in the public procurement of customers who provide services of different quality?”. The article identifies the stages of the hospital procurement process in the contract system and highlights the main customer strategies used in the auction. The results of an independent quality assessment are examined and comparative hospital characteristics with low and high quality rating are conducted. The hospital needs according to the types of purchases and their annual volumes of contracts are analyzed. The advantages of competitive procedures are determined and the key factors affecting the level of competition with possible risks of unreliable execution of contracts are identified. The empirical study is based on the database which includes 5390 contracts of 2 hospitals in Moscow for years of 2011–2017. Using the methods of econometric analysis, in particular, the method of least squares and the difference in the average, the hypothesis is tested the high competition has a positive effect on the quality of medical services. The constructed regression models show that the customer providing high quality services has low competition and small rebates at the auction. At the same time there are more contract terms, delays in the supply of goods and services as compared with the customer providing low quality services. Thus it was found that the underestimation of competition at the auction indicates the desire of the hospital to guarantee a higher quality of medical services to patients while as aggressive bids of participants lead to the supply of poor purchases. The results of the study may be useful for the competent authorities in the development of legal acts for the participants of the contract system in the field of health procurement.
Human Capital of the Enterprise in the Context of System Economy
Authors: Zhdanov Dmitry A.
Published: January 2021

One of the key factors that determine the success of the company and ensure its ongoing development, adaptation to the requirements of the digital economy, is the human capital (HC) of the enterprise. In this regard, the purpose of the study is designated as identifying ways to support the integral and sustainable growth of a company based on the development of its human capital. Since an enterprise is an open socio-economic system, the methodological basis of the work is the systems economic theory, which made it possible to present the company's activities as the interaction of object, environmental, process and project systems. Based on this concept and taking into account the objectives traditionally pursued by the company, four basic functional complexes have been identified that ensure the stability and reproductive capabilities of the enterprise, the challenges that need to be overcome within such capabilities were identified, the requirements for the knowledge, skills and abilities of personnel were established. Comparison of the human resources of the enterprise and the features of the corporate tasks solved with their help made it possible to group the elements of the company's HC in a new way – depending on the impact on the noted basic subsystems that determine the integrity of the company. This systematization demonstrated the interconnection of individual elements of the enterprise's HC and the performance of the corresponding complexes. Thus, the probable personnel reasons for the lag in certain areas of the company's activity and the possibilities of their reorganization by targeted impact on the required elements of the HC were identified. Since the implementation of the proposed approach requires the determination of the status of the corporate HC, and the reliability of such a procedure traditionally raises criticism due to the objective difficulties of measurement, the article proposes a methodology to streamline the process of assessing the state of the parameters under study. The methodology is based on the ranking of HC indicators depending on the accuracy of displaying the parameters of the object. The proposed approach made it possible to determine the tools for monitoring the selected categories of human capital, ways to step them up and remedy the situation.
Strategies for the Creation of Social and Economic Development Centers at the Mesolevel
Authors: Agafonov Vladimir A.
Published: January 2021

At the present stage of social and economic development of our country, the task of developing the institute of strategic planning is extremely urgent. The most important component of this institute is the system of strategic management at the regional level. The formation of regional development centers is an important factor in the sustainable development of regions and problems. The aim of this study is the principles and methods of implementation into the management system of procedures for the development and implementation of the strategy for the formation of regional development centers. The subject of the study are the principles and prerequisites for the development of a strategy for their formation. The basic provisions of general system theory are used as a methodological basis. The results of the study can be used in the development of regional development strategies and targeted programs.
Educação a distância, mídia e indivíduo na sociedade pós-moderna: reflexões sobre educação e cultura mediatizada pelo consumo
Authors: Seeger Fabiano Dutra , Ghisleni Taís Steffenello , Bortoluzzi Valéria Iensen
Published: January 2021

Nos últimos dez anos a Educação a distância tem ganhado destaque no contexto social da Educação no Brasil, principalmente pelo significativo aumento do total de alunos de ensino superior matriculados nesta modalidade. O papel da mídia e as características contemporâneas da sociedade podem expor fatores substanciais para a formação de uma cultura voltada para o consumo, interferindo nos modos de pensar, agir e consumir dos indivíduos, inclusive no campo da Educação. Para tanto, foi realizada uma pesquisa bibliográfica por meio escrito e eletrônico. Entre os meses de abril e junho de 2020, nas pesquisas eletrônicas, foram acessadas as bases de dados do Google Acadêmico, Google tradicional, Scielo e Lilacs, indicadas na metodologia deste estudo. E diante deste tema, o presente estudo visou caracterizar subsídios referentes a seguinte questão: qual o papel da mídia e das características da atual sociedade (pós-moderna) nas mudanças da educação de ensino superior brasileira diante de uma cultura mediatizada pelo consumo? A realização deste evidenciou que a influência da mídia, e das características sociais atuais, é determinante na relação dos indivíduos com o consumo, inclusive no âmbito da educação. Através do consumo, o sujeito busca sua personalização.
PEMBERDAYAAN MASYARAKAT MELALUI KELOMPOK SWABANTU DALAM MENGELOLA SAMPAH MENJADI APE ANAK USIA DINI
Authors: ERMAN KURNIAWAN ERMAN WICAKSONO
Published: January 2021

Waste in the most common problem in the world, not only in developin countries but also in developed countries. Waste has always been a major problem. Good knowledge of waste management followed by the attitude of parent’s who support waste management as an educational game tool is one ay to solve the waste problem. Community empoerment activities in managing waste are very helpful in overcoming waste volume accumulation. Knowing the effect of community empowerment through self-help groups on the knowledge and attitudes of parents in waste management becomes an Educational Game Tool. The study used a pre-experimental design with one group pre-test and postest approaches given to 24 respondent. The level of knowledge and attitudes in managing waste into an educational game was obtained by e questionnaire. The statistical test used Wilcoxon. The results of the bivariate analysis obtained p=0.002 which showed that there is an effect of community empowerment through self-help groups on the knowledge and attitudes of parents in processing waste into educational games. This study shows that before the waste management extension intervention was carried, 3 respondents were categorized as sufficient in attitude. And after being given the intervention, 24 respondent got a god category in knowledge, and 21 respondent were in a good category in attitude. Counseling on waste management (recycling) should be carried out regularly to assist the community in reducing waste accumulation, knowledge and attitudes in managing waste
HUBUNGAN KETERBUKAAN STATUS HIV DENGAN STIGMA DIRI PADA ORANG DENGAN HIV/AIDS
Authors: Pujilestari Nurullah Ika
Published: January 2021

Latar Belakang: Respon ODHA setelah mengetahui bahwa dirinya terkena HIV/AIDS ialah syok, cemas, takut, khawatir, rasa bersalah, dan menyalahkan diri sendiri. ODHA masih mempunyai ketakutan untuk mengungkapkan status penyakitnya karena adanya stigma negatif terhadap diri sendiri mengenai HIV/AIDS.Tujuan: Mengetahui hubungan keterbukaan status HIV dengan stigma diri pada ODHA di Jombang Care Center Plus (JCC+) Kabupaten Jombang.Metode Penelitian: Desain penelitian adalah survey analitik korelasi dengan pendekatan Cross-Sectional. Teknik sampel yaitu Purposive Sampling dengan jumlah sampel 55 responden ODHA di Jombang Care Center (JCC+). Instrumen penelitian menggunakan kuesioner Self Disclosure Scale dan kuesioner skala stigma Selected Berger Scale. Analisa data menggunakan uji Korelasi Pearson.Hasil Penelitian: Hasil analisis data menunjukkan besarnya koefisien korelasi r= 0,200 dengan taraf signifikan p=0,143 (p>0,05), artinya tidak ada hubungan yang bermakna antara keterbukaan status HIV dengan stigma diri pada ODHA di Jombang Care Center Plus (JCC+) Kabupaten Jombang.Kesimpulan: Dapat d simpulkan bahwa tidak ada hubungan antara keterbukaan status HIV dengan stigma diri pada ODHA di Jombang Care Center Plus (JCC+) Kabupaten Jombang.Saran: ODHA lebih mengembangkan konsep diri positif seperti mencoba bersosialisasi dengan orang lain dengan cara bergabung dengan orang-orang yang dapat memberikan dukungan dan semangat pada ODHA
Glutathione Reductase Is Inhibited by Acetaminophen-glutathione
Conjugate In Vitro
Authors: Roušar T , Pařík P , Kučera O , Bartoš M , Červinková Z
Published: January 2021

The aim of the present work was to investigate a new
mechanism likely contributing to the toxic action of
acetaminophen, especially to explore the possible inhibition of
glutathione reductase through an acetaminophen-glutathione
conjugate (APAP-SG). APAP-SG conjugate was synthesized by
organic synthesis and purified by column chromatography. The
inhibitory effect of the conjugate on two types of glutathione
reductase (from yeasts and rat hepatocytes) was tested spectrophotometrically. We found that the enzyme activity was reduced
similarly after the treatment with 2.96 mM acetaminophenglutathione conjugate in both yeast and hepatocyte glutathione
reductases (GR); the enzyme activity was inhibited to
52.7±1.5 % (2.4±0.3 mU/ml) in yeast GR (control activity was
5.6±0.3 mU/ml) and to 48.1±8.8 % (2.2±0.2 mU/ml) in rat
hepatocytes lysate GR (control activity was 5.2±0.2 mU/ml). In
addition, the enzyme activity (from hepatocytes lysate) was
decreased to 79±7 %, 67±2 % and 39±7 %, in 0.37, 1.48 and
3.7 mM concentration of the conjugate, respectively. We found
that glutathione reductase, the essential enzyme of the
antioxidant system, was dose-dependently inhibited by the
product of acetaminophen metabolism – the conjugate of
acetaminophen and glutathione.
The state of phytoplankton in the Taganrog Bay and factors determining its development in 2017
Authors: Korneva Lyudmila G. , Glushchenko Galina Yu.
Published: January 2021

The work presents the results of a study of phytoplankton in Taganrog Bay of the Sea of Azov and the downstream reaches of the Don River (January, April – November 2017). During the study was identified the modern taxonomic composition (210 species of eukaryotic algae and cyanobacteria). Ecological and geographical analysis was showed the stability of the general structure of the plankton algoflora of the studied area compared with previous years of the study (1980s to early 2000s). The work also presents a characteristic of the seasonal dynamics of taxonomic, size structures, and coenotic composition of phytoplankton. During the study was noted the temporary and qualitative changes in composition of phytoplankton, which are indicate a high level of organic matter in the studied reservoirs and an increase in the heterotrophic component in the functioning of the Lower Don ecosystem. It was found that in the studied water bodies the important factor in the formation of composition and the structure of phytoplankton is salinity.
Extracts from healing without
Authors: Mathews Timothy
Published: January 2021

In a fine example of how critique can cast itself as lyrical essay (see also, on this, the interview with David Shields in this number of CounterText) – and, thereby too, of evolving forms of what is now recognised through the term ‘creative criticism’ – Tim Mathews reflects in this piece on Antony Gormley's exhibition at the Royal Academy of Art in the autumn of 2019. The focus is on how Gormley's sculptures invite and stage awareness of individual and community reflection on, and participation in, art. Both wide-ranging and intimate, it valuably reflects on the relatability of Gormley's work and on the responsibilities distinct in the gaze (both one's own and others’) upon art's dimensioning of the human – and the experientiality of that.
FORMS AND METHODS OF INTERSTATE EXCHANGE OF SCIENTIFIC AND TECHNOLOGICAL INFORMATION: RUSSIAN AND FOREIGN EXPERIENCE
Authors:   Russian Research Institute of Economics, Politics and Law in Science and Technology, Vasileva Irina , Pokrovskii Dmitriy , Rebrova Tatyana
Published: January 2021

Introduction. The purpose of this study is to analyse the forms and methods of interstate exchange of scientific and technical information (STI), in particular, to study the current status of the Russian Federation State STI System (SSTIS RF) as well as bodies responsible for the implementation of the STI system (incl. the CIS Interstate Coordination Council for Scientific and Technical Information (ICCSTI)) and the course of development of interstate cooperation in the exchange of scientific and technical information to ensure the innovative development of Russia. The analysis of international experience in the development of scientific and technical information systems, including the trends in the context of which this development takes place, can help identify possible areas for improvement and determine inconsistencies and development issues for the SSTIS RF. Methods. To assess the interstate exchange of scientific and technical information, a description of the Russian and international practices of information exchange and a general description of the features characteristic of the two systems were prepared. In the framework of the study, the methods of synthesis and analysis were used to generalise and identify the most significant characteristics of cooperation between countries in the exchange of scientific and technical information. Results and Discussion. This study analyses the peculiarities of the forms and methods of interstate STI exchange in Russia and abroad. The operation specifics of the domestic STI system and its structure, supported by the system of standards on information, librarianship and publishing (SIBID), were considered in the context of Russian experience. The peculiarities of the operation of the International Centre for Scientific and Technical Information (ICSTI), which is engaged in the development of international digital information infrastructure in many countries, including Russia, were considered. In terms of international experience of interstate exchange of STI, approaches to standardisation of information exchange are described, in particular, the Information for All programme; the programmes of the EU regional partnership were also considered. This paper also identifies the main tools for national STI systems that enter the global information space. Conclusion. An analysis of the historical aspects and the current state of STI exchange in Russia and abroad revealed shortcomings inherent in the STI system of the Russian Federation: low degree of optimisation in the system, low level of digitalisation and integration of the Russian STI system with systems of other countries. The paper proposes a number of measures for the development of interstate information exchange and cooperation in the field of STI.
SIMULATING THE IMPACT OF DIGITAL TECHNOLOGIES ON THE EDUCATION QUALITY METRICS
Authors:   State Academic University of Humanities, Dubinina Marina
Published: January 2021

Introduction. Digital technologies have become an integral part of the educational process in the modern world. The coronavirus pandemic accelerated their spread, allowed their new features to be tested, their advantages to be assessed and bottlenecks identified. It is thus relevant to develop regulatory measures to timely address the negative effects of global distance education and to take advantage of all its positive aspects. Methods. The study was conducted using regression analysis techniques. The monitoring data of the Programme for International Student Assessment (PISA) for 2009, 2012 and 2018 were used as a source of information (The PISA 2018 survey is currently the most recent one). These data were used to investigate the impact of the spread of digital technologies on the education quality metrics (reading literacy and numeracy) of students aged 15–16. To assess the spread of digital technologies, the following metrics were applied: the time spent by students on the Internet in an educational institution (2012 and 2018), the number of personal computers per student (2009 and 2012) and the share of students having a PC or a laptop at home (2009, 2012 and 2018). The share of spending per student in total public expenditure (2009 and 2012) and the share of teachers who have completed professional development courses in the last 3 months (2018) were also used for the analysis. Results and Discussion. The regression models constructed reflected the dual impact of digital technology on the quality of education. On the one hand, the use of PCs and laptops contributed to the higher levels of literacy and numeracy of students; on the other hand, the time spent on the Internet in school and at home during the school week had a negative impact on these indicators. In addition, a significant positive impact of the share of government spending per student in GDP per capita and teacher qualifications on testing results was established. Conclusion. Digital technologies and new devices have radically changed modern education. They help students develop technological skills, use their learning gains and share their knowledge. However, it is important to take into account that the quality of education may deteriorate due to the impact of digital technologies and to take timely governmental regulatory measures to prevent this.
Alpinia oxyphylla Miq. and Its Active Compound P-Coumaric Acid Promote Brain-Derived Neurotrophic Factor Signaling for Inducing Hippocampal Neurogenesis and Improving Post-cerebral Ischemic Spatial Cognitive Functions
Authors: He Yacong , Chen Shuang , Tsoi Bun , Qi Shuhua , Gu Bing , Wang Zhenxing , Peng Cheng , Shen Jiangang
Published: January 2021

Alpinia oxyphylla Miq. (AOM) is a medicinal herb for improving cognitive functions in traditional Chinese medicine for poststroke treatment, but its efficacies and underlying mechanisms remain unknown. In the present study, we tested the hypothesis that AOM could induce adult hippocampal neurogenesis and improve poststroke cognitive impairment via inducing brain-derived neurotrophic factor (BDNF) signaling pathway. In order to test the hypothesis, we performed both in vivo rat experiments using transient middle cerebral artery occlusion (MCAO) model and in vitro neural stem cell (NSC) experiments using oxygen–glucose deprivation plus reoxygenation. First, AOM treatment significantly up-regulated the expression of BDNF, tropomycin receptor kinase B (TrkB), and phosphorylated AKT (p-AKT) in the hippocampus, enhanced adult hippocampal neurogenesis, and improved the spatial learning/memory and cognitive functions in the post-MCAO ischemic rats in vivo. Next, in vitro studies confirmed p-coumaric acid (P-CA) to be the most effective compound identified from AOM extract with the properties of activating BDNF/TrkB/AKT signaling pathway and promoting NSC proliferation. Cotreatment of BDNF/TrkB-specific inhibitor ANA12 abolished the effects of P-CA on inducing BDNF/TrkB/AKT activation and the NSC proliferation. Finally, animal experiments showed that P-CA treatment enhanced the neuronal proliferation and differentiation in the hippocampus, improved spatial learning and memory functions, and reduced anxiety in the transient MCAO ischemic rats. In conclusion, P-CA is a representative compound from AOM for its bioactivities of activating BDNF/TrkB/AKT signaling pathway, promoting hippocampal neurogenesis, improving cognitive functions, and reducing anxiety in post–ischemic stroke rats.
Osteogenic Differentiation of Renal Interstitial Fibroblasts Promoted by lncRNA MALAT1 May Partially Contribute to Randall’s Plaque Formation
Authors: Zhu Zewu , Huang Fang , Xia Weiping , Zeng Huimin , Gao Meng , Li Yongchao , Zeng Feng , He Cheng , Chen Jinbo , Chen Zhiyong , Li Yang , Cui Yu , Chen Hequn
Published: January 2021

Background

The current belief is that Randall’s plaques (RP) constitute a nidus for the formation of idiopathic calcium oxalate stones, but the upstream events in RP formation remain unclear. The present study aimed to investigate whether RP formation shares similarities with biomineralization and to illustrate the potential role played by the lncRNA MALAT1 in osteogenic differentiation of human renal interstitial fibroblasts (hRIFs).

Materials and Methods

Biomineralization and MALAT1 expression were assessed in RP, and hRIFs were isolated and induced under osteogenic conditions for further experiments. The transcription initiation and termination sites in MALAT1 were identified by 5′ and 3′ RACE. RNA immunoprecipitation assays and luciferase assays were used to validate the interactions among MALAT1, Runx2 and miRNAs.

Results

Upregulated expression of osteogenic markers and MALAT1 was observed in RP and hRIFs induced with osteogenic medium. Biomineralization in RP and calcium phosphate (CaP) deposits in induced hRIFs were further verified by electron microscopy. Furthermore, overexpression of MALAT1 promoted the osteogenic phenotype of hRIFs, while treatment with a miR-320a-5p mimic and knockdown of Runx2 significantly suppressed the osteogenic phenotype. Further analysis showed that MALAT1 functioned as a competing endogenous RNA to sponge miR-320a-5p, leading to upregulation of Runx2 and thus promoting osteogenic differentiation of hRIFs.

Conclusion

Ectopic calcification and MALAT1 partially contributed to the formation of RP, in which MALAT1 might promote Runx2 expression to regulate osteogenic differentiation of hRIFs by sponging miRNA-320a-5p. The current study sheds new light on the lncRNA-directed mechanism of RP formation via a process driven by osteogenic-like cells.
Crosstalk Between Retinoic Acid and Sex-Related Genes Controls Germ Cell Fate and Gametogenesis in Medaka
Authors: Adolfi Mateus C. , Herpin Amaury , Martinez-Bengochea Anabel , Kneitz Susanne , Regensburger Martina , Grunwald David J. , Schartl Manfred
Published: January 2021

Sex determination (SD) is a highly diverse and complex mechanism. In vertebrates, one of the first morphological differences between the sexes is the timing of initiation of the first meiosis, where its initiation occurs first in female and later in male. Thus, SD is intimately related to the responsiveness of the germ cells to undergo meiosis in a sex-specific manner. In some vertebrates, it has been reported that the timing for meiosis entry would be under control of retinoic acid (RA), through activation of Stra8. In this study, we used a fish model species for sex determination and lacking the stra8 gene, the Japanese medaka (Oryzias latipes), to investigate the connection between RA and the sex determination pathway. Exogenous RA treatments act as a stress factor inhibiting germ cell differentiation probably by activation of dmrt1a and amh. Disruption of the RA degrading enzyme gene cyp26a1 induced precocious meiosis and oogenesis in embryos/hatchlings of female and even some males. Transcriptome analyzes of cyp26a1–/–adult gonads revealed upregulation of genes related to germ cell differentiation and meiosis, in both ovaries and testes. Our findings show that germ cells respond to RA in a stra8 independent model species. The responsiveness to RA is conferred by sex-related genes, restricting its action to the sex differentiation period in both sexes.
The Complex Roles and Therapeutic Implications of m6A Modifications in Breast Cancer
Authors: Wei Min , Bai Jing-Wen , Niu Lei , Zhang Yong-Qu , Chen Hong-Yu , Zhang Guo-Jun
Published: January 2021

Accumulating evidence indicates that N6-methyladenosine (m6A), which directly regulates mRNA, is closely related to multiple biological processes and the progression of different malignancies, including breast cancer (BC). Studies of the aberrant expression of m6A mediators in BC revealed that they were associated with different BC subtypes and functions, such as proliferation, apoptosis, stemness, the cell cycle, migration, and metastasis, through several factors and signaling pathways, such as Bcl-2 and the PI3K/Akt pathway, among others. Several regulators that target m6A have been shown to have anticancer effects. Fat mass and obesity-associated protein (FTO) was identified as the first m6A demethylase, and a series of inhibitors that target FTO were reported to have potential for the treatment of BC by inhibiting cell proliferation and promoting apoptosis. However, the exact mechanism by which m6A modifications are regulated by FTO inhibitors remains unknown. m6A modifications in BC have only been preliminarily studied, and their mechanisms require further investigation.
Identification of the Myogenetic Oligodeoxynucleotides (myoDNs) That Promote Differentiation of Skeletal Muscle Myoblasts by Targeting Nucleolin
Authors: Shinji Sayaka , Umezawa Koji , Nihashi Yuma , Nakamura Shunichi , Shimosato Takeshi , Takaya Tomohide
Published: January 2021

Herein we report that the 18-base telomeric oligodeoxynucleotides (ODNs) designed from the Lactobacillus rhamnosus GG genome promote differentiation of skeletal muscle myoblasts which are myogenic precursor cells. We termed these myogenetic ODNs (myoDNs). The activity of one of the myoDNs, iSN04, was independent of Toll-like receptors, but dependent on its conformational state. Molecular simulation and iSN04 mutants revealed stacking of the 13–15th guanines as a core structure for iSN04. The alkaloid berberine bound to the guanine stack and enhanced iSN04 activity, probably by stabilizing and optimizing iSN04 conformation. We further identified nucleolin as an iSN04-binding protein. Results showed that iSN04 antagonizes nucleolin, increases the levels of p53 protein translationally suppressed by nucleolin, and eventually induces myotube formation by modulating the expression of genes involved in myogenic differentiation and cell cycle arrest. This study shows that bacterial-derived myoDNs serve as aptamers and are potential nucleic acid drugs directly targeting myoblasts.
Sensing R-Loop-Associated DNA Damage to Safeguard Genome Stability
Authors: Rinaldi Carlo , Pizzul Paolo , Longhese Maria Pia , Bonetti Diego
Published: January 2021

DNA transcription and replication are two essential physiological processes that can turn into a threat for genome integrity when they compete for the same DNA substrate. During transcription, the nascent RNA strongly binds the template DNA strand, leading to the formation of a peculiar RNA–DNA hybrid structure that displaces the non-template single-stranded DNA. This three-stranded nucleic acid transition is called R-loop. Although a programed formation of R-loops plays important physiological functions, these structures can turn into sources of DNA damage and genome instability when their homeostasis is altered. Indeed, both R-loop level and distribution in the genome are tightly controlled, and the list of factors involved in these regulatory mechanisms is continuously growing. Over the last years, our knowledge of R-loop homeostasis regulation (formation, stabilization, and resolution) has definitely increased. However, how R-loops affect genome stability and how the cellular response to their unscheduled formation is orchestrated are still not fully understood. In this review, we will report and discuss recent findings about these questions and we will focus on the role of ATM- and Rad3-related (ATR) and Ataxia–telangiectasia-mutated (ATM) kinases in the activation of an R-loop-dependent DNA damage response.