bluuebunny/crossref_metadata_2025 huggingface dataset:
El concepto de diversidad biológica y la protección del medio ambiente marino en el Sistema Interamericano de Derechos Humanos
Authors: Abello-Galvis Ricardo , Arévalo-Ramírez Walter , Cuartas Ocampo Natalia
Published: April 2024

Este capítulo tiene como objeto analizar la Opinión Consultiva n.º 23 de 2017, de la Corte Interamericana de Derechos Humanos (Corte IDH), como uno de los avances más significativos en la protección del derecho al medio ambiente sano, reconociendo no solo su justiciabilidad como derecho autónomo, sino desarrollando el alcance de las obligaciones ambientales que se derivan de los deberes generales de respeto y garantía de los derechos a la vida y a la integridad personal. Específicamente, el presente capítulo analiza el rol esencial del concepto de diversidad biológica en la opinión consultiva y otras decisiones para la protección del medio ambiente en su conexión con las obligaciones internacionales del Estado en la protección de los derechos humanos.
Recreación como experiencia de ocio y gestión del tiempo libre
Authors: Rincón Cruz Carlos Andrés , Torres Murcia Yenny Paola , Vélez Almonacid Jesús Germán
Published: April 2024

El presente capítulo se ha construido a semejanza del desarrollo de un torneo recreativo y sus secciones están planteadas según las rondas por las que transita un equipo. En ese orden de ideas, la primera ronda hace una aproximación a los conceptos de tiempo libre y ocio; en la segunda ronda se reconstruye la experiencia de la Jefatura de Deportes y se describen las actividades realizadas en los últimos cinco años, enfocadas en la generación de ocio y la promoción del uso programado del tiempo libre. Se cierra con lo que se denomina ronda de clasificación, en la que se muestra las actividades realizadas durante la nueva normalidad.
On Customer (Dis-)Honesty in Unobservable Queues: The Role of Lying Aversion
Authors: Estrada Rodriguez Arturo , Ibrahim Rouba , Zhan Dongyuan
Published: April 2024

Queues where people misreport their private information to access service faster are everywhere. Motivated by the prevalence of such behavior in practice, we construct a queueing-game-theoretic model where customers make strategic claims to reduce their waiting time and where the manager decides on the static scheduling policy based on those claims to minimize the expected delay cost in the system. We develop a lying-aversion model where customers incur both delay and lying costs. We run controlled experiments to validate our modeling assumptions regarding customer misreporting behavior. In particular, we find that people do incur lying costs, and we find that their misreporting behavior does not depend on changes in waiting times but rather, on the scheduling parameters. Based on the validated lying-aversion model, we study the equilibrium that arises in our game. We find that under certain conditions, the optimal policy is to use an honor policy where service priority is given according to customer claims. We also find that it may be optimal to incentivize more honesty by means of an upgrading policy where some customers who claim to not deserve priority are upgraded to the priority queue. We find that the upgrading policy deviates from the celebrated cµ rule.

This paper was accepted by Elena Katok, operations management.

Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.04036 .
Sharpen Your Sword for Litigation: Incumbent Strategic Reaction to the Threat of Entry
Authors: Conti Annamaria , Ortega Leonardo , Sung Elie
Published: April 2024

While patents have been shown to play a role as barriers to entry, they also reveal information about incumbent strategies and risk being invalidated. We examine the trade-off incumbents face between using their patents ex ante as entry deterrents or ex post once competitors have revealed their moves. Leveraging the unique characteristics of the pharmaceutical sector, in which it is possible to observe exactly when a competitor entry threat materializes, and exploiting exogenous variation in that timing, we show that incumbents intentionally fragment and delay the full disclosure of their intellectual property rights through continuation patents. They disproportionately reveal continuation patents after a competitor entry threat becomes concrete, tailoring their response to the threat they have received and successfully delaying competitor entry through litigation. The detected incumbents’ reaction is stronger when their attacked drugs are valuable and when the patents listed at the Food and Drug Administration approval of a drug are relatively narrow in scope.

This paper was accepted by Alfonso Gambardella, business strategy.

Funding: A. Conti acknowledges funding from E4S. E. Sung acknowledges funding from the HEC Foundation [Grant 9B82F1905+] and the U.S. National Science Foundation [Grant 1759991].

Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2023.00900 .
Equilibrium Portfolio Selection for Smooth Ambiguity Preferences
Authors: Guan Guohui , Liang Zongxia , Xia Jianming
Published: April 2024

This paper investigates the equilibrium portfolio selection for smooth ambiguity preferences in a continuous-time market. The investor is uncertain about the risky asset’s drift term and updates the subjective belief according to the Bayesian rule. A verification theorem is established, and an equilibrium strategy can be decomposed into a myopic demand and two hedging demands. When the prior is Gaussian, we provide an equilibrium solution in closed form. Moreover, a puzzle in the numerical results is interpreted via an alternative representation of the smooth ambiguity preferences.

Funding: This work was supported by the National Key R&D Program of China [Grant 2020YFA0712700], the National Natural Science Foundation of China [Grants 11871036, 11901574, 12071146, 12271290, and 12371477], and the MOE Project of Key Research Institute of Humanities and Social Sciences [Grant 22JJD910003].
Early Period Assessment of the Nutritional Status of Child Patients in the Earthquake Zone
Authors: İnce Yunus Emre , Yüzdemir Hasan Salih
Published: April 2024

Objective:The objective of this study was to investigate the impact of earthquakes on the nutritional status and infection rates of children in the early stages of post-earthquake recovery.

Material and Methods: Following the earthquakes on February 6, 2023, 80 out of 504 patients who presented to the pediatric examination tent in Hatay province were included in the study. Reasons for patient visits and weight loss compared to pre-earthquake measurements were examined.

Results: A total of 80 patients were examined across three different age groups [1 month-5 years (29 patients), 5-10 years (34 patients), and 10-18 years (17 patients)]. In all three age groups, a statistically significant decline was observed in body weights, weight percentiles, and age-specific standard deviations when compared to their pre-earthquake measurements (p<0.001). Besides, frequently occurring illnesses were respiratory tract infections (51.25%) and acute gastroenteritis (38.75%).

Conclusion: Ensuring appropriate and adequate nutrition for children in the aftermath of a disaster is of critical importance for sustaining normal growth and preventing of diseases. Therefore, emergency plans should include expert pediatricians and prioritize children.
Epistemolgias moventes: processo de uma pesquisa como dança
Authors: Da Rosa Carolina Cony Dariano
Published: April 2024

O presente artigo apresenta o processo artístico de uma pesquisa de mestrado em educação, fundamentada numa epistemologia movente, sobre a qual desliza, também, a escrita. Os elementos de composição e as ferramentas artísticas da dança, como a improvisação, possibilitam outros modos de fazer, acolhendo o movimento, como fundamento de uma pesquisa com arte.
Monólogo para um artista aprendiz
Authors: Vinhosa Luciano
Published: April 2024

Neste ensaio apresento, em linhas gerais, algumas considerações que balizam minhacompreensão do fazer artístico como forma de pensar, tanto do ponto de vista teórico como dosprocedimentos operacionais.
Mediação em arte
Authors: Prado Lopes Ana Tereza , Queiroz Tania
Published: April 2024

Entrevista com Wendy Woon realizada no SESC, Rio de Janeiro, 11 de novembro de 2022.
Nem arte, nem educação
Authors: Camnitzer Luis
Published: April 2024

Tradução publicada no livro ARTEVERSA: arte, docência e outras invenções / (Orgs.) Luciana Gruppelli Loponte, Cristian PolettiMossi. – São Paulo: Pimenta Cultural, 2023. p.30-37.
Treatment-induced neuroendocrine prostate cancer and de novo neuroendocrine prostate cancer: Identification, prognosis and survival, genetic and epigenetic factors
Authors: Wishahi Mohamed
Published: April 2024

Neuroendocrine prostate cancer (NEPC) shows an aggressive behavior compared to prostate cancer (PCa), also known as prostate adenocarcinoma. Scanty foci in PCa can harbor genetic alternation that can arise in a heterogeneity of prostate cancer. NEPC may arise de novo or develop following androgen deprivation therapy (ADT). NEPC that arise following ADT has the nomenclature “treatment-emerging/induced NEPC (t-NEPC)”. t-NEPC would be anticipated in castration resistant prostate cancer (CRPC) and metastatic PCa. t-NEPC is characterized by low or absent androgen receptor (AR) expression, independence of AR signaling, and gain of neuroendocrine phenotype. t-NEPC is an aggressive metastatic tumor, develops from PCa in response to drug induced ADT, and shows very short response to conventional therapy. t-NEPC occurs in 10%-17% of patients with CRPC. De novo NEPC is rare and is accounting for less than 2% of all PCa. The molecular mechanisms underlying the trans-differentiation from CRPC to t-NEPC are not fully elucidated. Sphingosine kinase 1 plays a significant role in t-NEPC development. Although neuroendocrine markers: Synaptophysin, chromogranin A, and insulinoma associated protein 1 (INSM1 ) are expressed in t-NEPC, they are non-specific for diagnosis, prognosis, and follow-up of therapy. t-NEPC shows enriched genomic alteration in tumor protein P53 (TP53 ) and retinoblastoma 1 (RB1 ). There are evidences suggest that t-NEPC might develop through epigenetic evolution. There are genomic, epigenetic, and transcriptional alterations that are reported to be involved in development of t-NEPC. Knock-outs of TP53 and RB1 were found to contribute in development of t-NEPC. PCa is resistant to immunotherapy, and at present there are running trials to approach immunotherapy for PCa, CRPC, and t-NEPC.
Establishment and evaluation of a prognostic model for patients with unresectable gastric cancer liver metastases
Authors: Chang Zheng-Yao , Gao Wen-Xing , Zhang Yue , Zhao Wen , Wu Di , Chen Lin
Published: April 2024

BACKGROUND

Liver metastases (LM) is the primary factor contributing to unfavorable outcomes in patients diagnosed with gastric cancer (GC). The objective of this study is to analyze significant prognostic risk factors for patients with GCLM and develop a reliable nomogram model that can accurately predict individualized prognosis, thereby enhancing the ability to evaluate patient outcomes.

AIM

To analyze prognostic risk factors for GCLM and develop a reliable nomogram model to accurately predict individualized prognosis, thereby enhancing patient outcome assessment.

METHODS

Retrospective analysis was conducted on clinical data pertaining to GCLM (type III), admitted to the Department of General Surgery across multiple centers of the Chinese PLA General Hospital from January 2010 to January 2018. The dataset was divided into a development cohort and validation cohort in a ratio of 2:1. In the development cohort, we utilized univariate and multivariate Cox regression analyses to identify independent risk factors associated with overall survival in GCLM patients. Subsequently, we established a prediction model based on these findings and evaluated its performance using receiver operator characteristic curve analysis, calibration curves, and clinical decision curves. A nomogram was created to visually represent the prediction model, which was then externally validated using the validation cohort.

RESULTS

A total of 372 patients were included in this study, comprising 248 individuals in the development cohort and 124 individuals in the validation cohort. Based on Cox analysis results, our final prediction model incorporated five independent risk factors including albumin levels, primary tumor size, presence of extrahepatic metastases, surgical treatment status, and chemotherapy administration. The 1-, 3-, and 5-years Area Under the Curve values in the development cohort are 0.753, 0.859, and 0.909, respectively; whereas in the validation cohort, they are observed to be 0.772, 0.848, and 0.923. Furthermore, the calibration curves demonstrated excellent consistency between observed values and actual values. Finally, the decision curve analysis curve indicated substantial net clinical benefit.

CONCLUSION

Our study identified significant prognostic risk factors for GCLM and developed a reliable nomogram model, demonstrating promising predictive accuracy and potential clinical benefit in evaluating patient outcomes.
Yiwei Xiaoyu granules for treatment of chronic atrophic gastritis with deficiency syndrome of the spleen and stomach
Authors: Chen Wan-Qun , Fan Qing-Feng , He Yuan-Jun , Li Fei , Wu Xin , Li Yan-Ping , Yang Xiao-Jun
Published: April 2024

BACKGROUND

The Correa sequence, initiated by Helicobacter pylori (H. pylori ), commonly progresses to gastric cancer through the stage of chronic atrophic gastritis (CAG). Although eradication of H. pylori only reduces the risk of gastric cancer, it does not eliminate the risk for neoplastic progression. Yiwei Xiaoyu granules (YWXY) are a commonly used composite preparation in Chinese clinics. However, the pursuit of excellence in clinical trials and the establishment of standardized animal experiments are still needed to contribute to full understanding and application of traditional Chinese medicine in the treatment of CAG.

AIM

To demonstrate the effectiveness of YWXY in patients with CAG and spleen-stomach deficiency syndrome (DSSS), by alleviating histological scores, improving response rates for pathological lesions, and achieving clinical efficacy in relieving DSSS symptoms.

METHODS

We designed a double-blind, randomized, controlled trial. The study enrolled seventy-two H. pylori -negative patients (mean age, 52.3 years; 38 men) who were randomly allocated to either the treatment group or control group in a 1:1 ratio, and treated with 15 g YWXY or 0.36 g Weifuchun (WFC) tablet combined with the respective dummy for 24 wk. The pre-randomization phase resulted in the exclusion of 72 patients: 50 participants did not meet the inclusion criteria, 12 participants declined to participate, and 10 participants were excluded for various other reasons. Seven visits were conducted during the study, and histopathological examination with target endoscopic biopsy of narrow-band imaging was requested before the first and seventh visits. We also evaluated endoscopic performance scores, total symptom scores, serum pepsinogen and gastrin-17.

RESULTS

Six patients did not complete the trial procedures. Treatment with YWXY improved the Operative Link on Gastric Intestinal Metaplasia Assessment (OLGIM) stage, compared with WFC (P < 0.05). YWXY provided better relief from symptoms of DSSS and better improvement in serum gastric function, compared with WFC (P < 0.05).

CONCLUSION

YWXY compared with WFC significantly reduced the risk of mild or moderate atrophic disease, according to OLGIM stage, significantly relieved symptoms of DSSS, and improved serum gastric function.
Airway management of a patient with linear immunoglobulin A bullous dermatosis: A case report
Authors: Nin Olga C , Hutnik Robert , Chheda Neil N , Hutchinson David
Published: April 2024

BACKGROUND

There is limited literature on managing the airway of patients with linear immunoglobulin A (IgA) bullous dermatosis, a rare mucocutaneous disorder that leads to the development of friable bullae. Careful clinical decision making is necessary when there is a risk of bleeding into the airway, and a multidisciplinary team approach may lead to decreased patient morbidity during these high-risk scenarios, especially when confronted with an unusual cause for bleeding.

CASE SUMMARY

A 45-year-old African American female presented to our ambulatory surgical center for right corneal transplantation due to corneal perforation after blunt trauma in the setting of cicatricial conjunctivitis and diffuse corneal neovascularization from linear IgA bullous dermatosis. The diagnosis of IgA dermatosis was recent, and the patient had been lost to follow-up. The severity of the disease and extent of airway involvement was unknown at the time of the surgery. Significant airway bleeding was noticed upon intubation and the otorhinolaryngology team had to be called to the operating room. The patient required transfer to the intensive care unit where a multidisciplinary team was involved in her case. The patient was extubated on postoperative day 4.

CONCLUSION

A multidisciplinary approach to treating this disease is the best course of action before a surgical procedure. In our case, key communication between the surgery, anesthesia, and dermatology teams led to the quick and safe treatment of our patient’s disease. Ambulatory surgery should not be considered for these cases unless they are in full remission and there is no mucous membrane involvement.
Atypical presentation of a posterior fossa tumour: A case report
Authors: Narotam Alisha , Archary Mikara , Naidoo Poobalan , Naidoo Yeshkhir , Naidu Vanesha
Published: April 2024

BACKGROUND

We described a case of a patient with a meningioma in the posterior fossa presenting atypically with an isolated unilateral vocal cord palsy causing severe respiratory distress. This is of interest as the patient had no other symptomatology, especially given the size of the mass, which would typically cause a pressure effect leading to neurological and auditory symptoms.

CASE SUMMARY

This case report described a 48-year-old male who was married with two children and employed as a car guard. He had a medical history of asthma for the past 10 years controlled with an as-needed beta 2 agonist metered dose inhaler. He initially presented to our facility with severe respiratory distress. He reported a 1-wk history of shortness of breath and wheezing that was not relieved by his bronchodilator. He had no constitutional symptoms or impairment of hearing. On clinical examination, the patient’s chest was “silent.” Our initial assessment was status asthmaticus with type 2 respiratory failure, based on the history of asthma, a “silent chest,” and the arterial blood gas results.

CONCLUSION

A posterior fossa meningioma of such a large size and with extensive infiltration rarely presents with an isolated unilateral vocal cord palsy. The patient’s chief presenting feature was severe respiratory distress, which combined with his background medical history of asthma, was misleading. Clinicians should thus consider meningioma as a differential diagnosis for a unilateral vocal cord palsy even without audiology involvement.
Hand and Wrist trauma: Antimicrobials and Infection Audit of Clinical Practice (HAWAII ACP) protocol
Authors: Shafi Shiraz Q. , Yoshimura Ryo , Harrison Conrad J. , Wade Ryckie G. , Shaw Abigail V. , Totty Joshua P. , Rodrigues Jeremy N. , Gardiner Matthew D. , Wormald Justin C. R.
Published: April 2024

Aims

Hand trauma, consisting of injuries to both the hand and the wrist, are a common injury seen worldwide. The global age-standardized incidence of hand trauma exceeds 179 per 100,000. Hand trauma may require surgical management and therefore result in significant costs to both healthcare systems and society. Surgical site infections (SSIs) are common following all surgical interventions, and within hand surgery the risk of SSI is at least 5%. SSI following hand trauma surgery results in significant costs to healthcare systems with estimations of over £450 per patient. The World Health Organization (WHO) have produced international guidelines to help prevent SSIs. However, it is unclear what variability exists in the adherence to these guidelines within hand trauma. The aim is to assess compliance to the WHO global guidelines in prevention of SSI in hand trauma.

Methods

This will be an international, multicentre audit comparing antimicrobial practices in hand trauma to the standards outlined by WHO. Through the Reconstructive Surgery Trials Network (RSTN), hand surgeons across the globe will be invited to participate in the study. Consultant surgeons/associate specialists managing hand trauma and members of the multidisciplinary team will be identified at participating sites. Teams will be asked to collect data prospectively on a minimum of 20 consecutive patients. The audit will run for eight months. Data collected will include injury details, initial management, hand trauma team management, operation details, postoperative care, and antimicrobial techniques used throughout. Adherence to WHO global guidelines for SSI will be summarized using descriptive statistics across each criteria.

Discussion

The Hand and Wrist trauma: Antimicrobials and Infection Audit of Clinical Practice (HAWAII ACP) will provide an understanding of the current antimicrobial practice in hand trauma surgery. This will then provide a basis to guide further research in the field. The findings of this study will be disseminated via conference presentations and a peer-reviewed publication.

Cite this article: Bone Jt Open 2024;5(4):361–366.
CDH2-microRNA Axis Provides Insights into Sustained Breast Cancer Dormancy in the Bone Marrow Niche
Authors: Sinha Garima , Conaty Peter , Patel Shyam A. , Yehia Ghassan , Vemula Sai , Rameshwar Pranela
Published: April 2024

Despite long-term remission of breast cancer (BC), cancer resurgence remains a clinical issue. This issue is mostly due to BC cells (BCCs) being able to survive in dormancy for decades. This is particularly relevant to the bone marrow (BM) where the dormant BCCs survive as cancer stem cells (CSCs). The BM niche maintains BCCs in dormancy, and also mediates dedifferentiation of BCCs to CSCs. Since dormancy can occur at any time during the disease, including decades before clinical diagnosis, it is important to understand how these cells survive to allow for the development of safe treatments. Dormant BCCs establish gap junctional intercellular communication (GJIC) with BM niche such as fibroblasts and mesenchymal stem cells (MSCs). GJIC requires connexin 43 (Cx43) but cannot be a safe target since this connexin is also important for hematopoietic function. This study focused on N-cadherin (CDH2) because it facilitates Cx43-mediated GJIC between BCCs and BM niche cells. We found Cx43 and CDH2 mutually regulated their gene expression. Cloning of the 5′ regulatory regions of CDH2 unraveled DNA sequences as possible elements of repressor and activator transcription. We identified potential transcription factors (TFs) that could regulate CDH2 and showed how miRNAs that could cross GJIC might be responsible for regulating the TFs. The axis developed by CDH2 and miRNAs provide insights into how CDH2 is maintained at low level to sustain BC dormancy. The findings, together with previous findings, provide avenues for therapeutic intervention to safely reverse and target dormant BCCs in the BM niche.
Advances in Stem Cell and Regenerative Therapies in Autoimmune and Metabolic Diseases: Implications for Healthy Longevity
Authors: Lakey Jonathan R. T. , Alexander Michael , Chan Mike K. S. , Nalapko Yuriy , Wong Michelle B. F. , Cox Desiree C. T.
Published: April 2024

Type 1 diabetes (T1D) is an important autoimmune disease characterized by the destruction of insulin-secreting β-cells in pancreatic islets of Langerhans resulting in hyperglycemia. More than 1.3 people in United States are suffering from T1D, and current treatments have failed to offer a lasting cure. T1D management requires lifelong daily injections of exogenous insulin to control blood sugar levels and secondary complications of this progressive disease, unless receiving pancreas or islet transplant with its associated risks from immunosuppression.
Peptide therapy aims to alter the response of cells by inducing or reducing cellular responses appropriate to the type of peptides used. The aim of this study was to investigate the protective effect on autoimmunity of Mito Organelle (MO) Peptides on the function and survival of peptides on pancreatic β-cells in non-obese diabetes (NOD) mice model. MO peptide product (Biopep Inc) is a mixture of organ-specific cellular extracts that were extracted from organ specific cells, homogenized, filtered, and sterilized.
MO Peptides administered twice-weekly (IM) over 17-week period in NOD mice model were able to prevent the progression of autoimmune-mediated β–cell destruction and the onset of hyperglycemia (blood glucose >300 mg dL) as compared to the saline treated control mice.
These studies will help understand the mechanisms of immunological protection in T1D and may serve as a model for other autoimmune disorders with peptides.
What Could Explain Delay for Age-Reversal Clinical Trials?
Authors: Faloon William
Published: April 2024

This is a commentary article using data reported by the United States Drug Approval (FDA) system for clinical trials. The text surmised reasons for this delay. The data show continued delay to impact drugs reaching patients. Instead of increasing drug approval, the statistics showed a trend of increased numbers of drug on hold. The reason for these delays need to be evaluated, and perhaps to apply new technologies to evaluate the data.
Parábolas y razonamiento intuitivo: una experiencia piloto apoyada en la Didáctica de las Matemáticas
Authors: Sousa Renata Teófilo de , Alves Francisco Régis Vieira
Published: April 2024

Existen lagunas en la formación del profesorado de matemáticas sobre la parábola y un escaso abordaje del tema en la Educación Básica y Superior brasilera, especialmente con el uso de la tecnología. Así, nos preguntamos: ¿Cómo puede la Teoría de las Situaciones Didácticas proporcionar la construcción de un modelo didáctico para enseñar el concepto de parábola? Este trabajo es el resultado de una experiencia piloto en un curso de maestría que aborda la parábola desde diferentes puntos de vista. El objetivo es identificar posibles obstáculos didácticos en su enseñanza a partir de un análisis de manifestaciones intuitivas en una situación didáctica con apoyo del GeoGebra. Utilizamos la Teoría de las Situaciones Didácticas en la estructuración de la sesión de enseñanza y las Categorías del Razonamiento Intuitivo para el análisis de los datos recolectados. La metodología fue la Ingeniería Didáctica, la cual fue experimentada con un alumno de la Licenciatura en Matemáticas. La observación y la recolección de datos nos proporcionaron elementos para el análisis a posteriori y la validación del experimento, en el que verificamos la necesidad de discutir la parábola, articulando sus visiones geométrica, algebraica y analítica, así como el uso de la tecnología en su enseñanza.
Escape Game para mejorar las competencias y habilidades de los futuros docentes de Educación Primaria. Una experiencia didáctica
Authors: Eusebio Hermira Sonia
Published: April 2024

Analizamos la influencia de la gamificación, y en concreto del Escape Game, en el aprendizaje y la adquisición de competencias generales, transversales y específicas del Grado de Educación Primaria, así como en el desarrollo de habilidades de comprensión, expresión, interacción y mediación. Asimismo, se determinan las características que deben cumplir las tareas del Escape Game para que puedan ser efectivas en el desarrollo de competencias y habilidades y se evalúan las mecánicas y dinámicas específicas que pueden ser más efectivas para el aprendizaje y la evaluación en el contexto de la Educación Primaria. Los resultados ofrecen una base sólida para el diseño y la implementación de prácticas pedagógicas innovadoras y efectivas en el ámbito de la gamificación para la mejora de la formación de los futuros maestros de Educación Primaria.
Prohibir la tecnologia en un context digital. Els mòbils a l’aula
Authors: Gisbert Cervera Mercè
Published: April 2024

Editorial nº 15.
Redescobrir l'esperit salvatge
Authors: Ferrando Stefania
Published: April 2024

El plaer femení té una relació especial amb la llibertat. Però, de quina llibertat es tracta? És la mateixa llibertat que està en joc quan es renuncia al plaer clitòric? L’article treballa sobre aquestes qüestions, proposant donar un significat específic a la paraula llibertat quan acompanya i sosté el plaer femení. El text proposa primer una reflexió sobre el concepte de llibertat i troba una tradició alternativa a la de la filosofia acadèmica. Prossegueix dialogant amb els escrits de María-Milagros Rivera Garretas, Barbara Verzini i Carla Lonzi. Una de les apostes importants és pensar en la possibilitat de relacions amoroses, fins i tot amb homes, en què no hi hagi renúncia al plaer, ni renúncia a si mateixa, ni subterfugi o fugida de si mateixa o de la relació.
"Statues Made of Sugar": Martí, Monuments, and Hemispheric Ventriloquism
Authors: Hooker Juliet
Published: April 2024

Abstract: Monuments speak; they shape citizens' political imaginations. Drawing on an essay by the Cuban intellectual José Martí about Confederate commemoration, I argue that his Confederate solidarities were the result of hemispheric ventriloquism. Widely lauded as an anti-imperial and anti-racist thinker, Martí's hemispheric ventriloquism was driven by: 1) fears of US imperial expansion; 2) a need to rebut critiques of republics as inherently unstable forms of government in light of post-independence civil strife in Latin America; and 3) his hopes for Cuban national unity post-independence. Martí's hemispheric ventriloquism illustrates the dangers of downplaying racist commemoration in the name of liberal pluralism or national unity.
Deleuze and Guattari on the French Revolution: Problems, Universal Minority, and the Bourgeoisie
Authors: Underwood Alex
Published: April 2024

Abstract: This article explores Deleuze and Guattari's theory of revolution in light of their comments on the French Revolution and intersection with the work of Marx. I argue that Deleuze associates revolution with a reformulation of the "problems" that condition experience, something Deleuze and Guattari then complicate through their insistence that institutional practice remain subject to the unfolding of an "indeterminate" yet collective revolutionary identity. I argue that the most important aspect of their theory for contemporary political thought is its argument for the necessity of uniting disparate forms of political experimentation without introducing institutions grounded in general conceptions of the subject, and conclude by discussing the emphasis they place on overcoming the "cogito of communication," a discursive "subject in general" essential to contemporary capitalist democracies.
Hybrid meta/refractive lens design with an inverse design using physical optics
Authors: Shih Ko-Han , Renshaw C. Kyle
Published: April 2024

Hybrid lenses are created by combining metasurface optics with
refractive optics, where refractive elements contribute optical power,
while metasurfaces correct optical aberrations. We present an
algorithm for optimizing metasurface nanostructures within a hybrid
lens, allowing flexible interleaving of metasurface and refractive
optics in the optical train. To efficiently optimize metasurface
nanostructures, we develop a scalar field, ray-wave hybrid propagation
method. This method facilitates the propagation of incident and
derived adjoint fields through optical elements, enabling effective
metasurface optimization within the framework of adjoint gradient
optimization. Numerical examples of various lens configurations are
presented to illustrate the versatility of the algorithm and showcase
the benefits offered by the proposed approach, allowing metasurfaces
to be positioned beyond the image space of a lens. Taking a F/2, 40°
field-of-view, midwave infrared lens as an example, the lens exhibits
an average focusing efficiency of 38% before the integration of
metasurfaces. Utilizing the new algorithm to design two
metasurfaces—one in the object space and one in the image
space—results in significant enhancement of the average focusing
efficiency to over 90%. In contrast, a counterpart design with both
metasurfaces limited to the image space yields a lower average
focusing efficiency of 73%.
Measuring the radius of curvature of spherical surfaces with actively tunable Fizeau and Twyman-Green interferometers
Authors: Kim Minjae , Imeri Arjent , Reza Syed Azer
Published: April 2024

Accurate and repeatable measurement of the radius of curvature (RoC) of
spherical sample surfaces is of great importance in optics. This
importance lies in the ubiquitous use of spherical optical elements
such as curved mirrors and lenses. Due to a high measurement
sensitivity, interferometric techniques are often deployed for
accurate characterization of the sample surface RoC. One method by
which a typical commercial Fizeau or Twyman-Green (TG) interferometer
measures surface RoC is via scanning between two principal
retroreflective optical configurations—namely, the confocal and
catseye configurations. Switching between these two configurations is
typically achieved by moving an optical head along the axis of the
propagating laser beam and the RoC is estimated by measuring the
magnitude of mechanical motion to switch between the two principal
configurations. In this paper, we propose a motion-free
catseye/confocal-imaging-based sample RoC measurement system. The
necessity of bulk motion to switch between the two configurations is
circumvented via the use of an actively controlled varifocal lens. We
demonstrate the usefulness of the proposed innovation in RoC
measurements with either the TG or the Fizeau interferometer.
Furthermore, we convert a commercial motion-based Zygo RoC measurement
system into a motion-free one by introducing a tunable lens inside the
apparatus and using it to accurately characterize the RoC of different
test samples. We also compute the wavefront aberrations for all
spherical sample surfaces from the recorded measurement data.
Fabry-Pérot laser diode spectrum switching by controllable self-injection locking to a high-quality-factor optical microresonator
Authors: Galkin Maxim L. , Chermoshentsev Dmitry A. , Pavlov Vladislav I. , Shitikov Artem E. , Lonshakov Evgeny A. , Lobanov Valery E. , Bilenko Igor A.
Published: April 2024

We propose a technique for automatic search and identification of possible generation regimes of a commercial multimode Fabry-Pérot laser diode self-injection locked to a high-quality-factor whispering gallery mode microresonator. Such a technique provides the potential for controllable switching between regimes with different wavelengths and with a specific number of lasing modes.
Doubly resonant metal-free electro-optic microwave receiver in aluminum nitride
Authors: Lipkowitz Steven T. , Berk Warren P. , Grutter Karen E. , Murphy Thomas E.
Published: April 2024

This paper demonstrates a passive, integrated electro-optic receiver for detection of free-space microwave radiation. Unlike a traditional microwave receiver, which relies on conductive antennas and electrical amplifiers, this receiver uses only passive, optically probed elements with no electrodes or electronic components. The receiver employs two co-resonant structures: a dielectric resonator antenna (DRA) to concentrate incoming microwave radiation and an integrated aluminum nitride (AlN) racetrack resonator to resonantly enhance the optical carrier. The microwave field of the DRA modulates the built-up optical carrier in the resonator via the electro-optic response of AlN. We successfully detected 15 GHz microwave radiation through co-resonant electro-optic up-conversion, without the need for any conducting electrodes, amplifiers, or electronic components.
Distribution of telecom entangled photons through a 7.7 km antiresonant hollow-core fiber
Authors: Antesberger Michael , Richter Carla M. D. , Poletti Francesco , Slavík Radan , Petropoulos Periklis , Hübel Hannes , Trenti Alessandro , Walther Philip , Rozema Lee A.
Published: April 2024

State of the art classical and quantum communications rely on standard
optical fibers with solid cores to transmit light over long distances.
However, recent advances have led to the emergence of antiresonant
hollow-core optical fibers (AR-HCFs), which, due to the novel fiber
geometry, show remarkable optical guiding properties, which are not as
limited by the material properties as solid-core fibers. In this
paper, we explore the transmission of entangled photons through a
novel 7.7 km AR-HCF in a laboratory environment at 1550 nm, presenting
the first successful demonstration of entanglement distribution via a
long AR-HCF. In addition to showing these novel fibers are compatible
with long distance quantum communication, we highlight the low latency
and low chromatic dispersion intrinsic to AR-HCF, which can increase
the secure key rate in time-bin-based quantum key distribution
protocols.
The interplay between climate change and ageing: A systematic review of health indicators
Authors: Figueiredo Teodora , Midão Luís , Rocha Pedro , Cruz Sara , Lameira Gisela , Conceição Paulo , Ramos Rui J. G. , Batista Luísa , Corvacho Helena , Almada Marta , Martins Ana , Rocha Cecília , Ribeiro Anabela , Alves Fernando , Costa Elísio
Published: April 2024

Climate change and rapid population ageing pose challenges for communities and public policies. This systematic review aims to gather data from studies that present health indicators establishing the connection between climate change and the physical and mental health of the older population (≥ 65 years), who experience a heightened vulnerability to the impacts of climate change when compared to other age cohorts. This review was conducted according to the PICO strategy and following Cochrane and PRISMA guidelines. Three databases (PubMed, Scopus and Greenfile) were searched for articles from 2015 to 2022. After applying inclusion and exclusion criteria,nineteen studies were included. The findings indicated that various climate change phenomena are associated with an elevated risk of mortality and morbidity outcomes in older adults. These included cardiovascular, respiratory, renal, and mental diseases, along with physical injuries. Notably, the impact of climate change was influenced by gender, socioeconomic status, education level, and age—vulnerability factors. Climate change directly affected the health of older adults through ambient temperature variability, extreme and abnormal temperatures, strong winds, sea temperature variability, extreme El Niño-southern Oscillation (ENSO) conditions and droughts, and indirectly by air pollution resulting from wildfires. This review presents further evidence confirming that climate change significantly impacts the health and well-being of older adults. It highlights the urgency for implementing effective strategies to facilitate adaptation and mitigation, enhancing the overall quality of life for all individuals.
Fecal DNA metabarcoding helps characterize the Canada jay’s diet and confirms its reliance on stored food for winter survival and breeding
Authors: Sutton Alex O. , Strickland Dan , Lachapelle Jacob , Young Robert G. , Hanner Robert , Brunton Daniel F. , Skevington Jeffrey H. , Freeman Nikole E. , Norris D. Ryan
Published: April 2024

Accurately determining the diet of wild animals can be challenging if food items are small, visible only briefly, or rendered visually unidentifiable in the digestive system. In some food caching species, an additional challenge is determining whether consumed diet items have been previously stored or are fresh. The Canada jay (Perisoreus canadensis) is a generalist resident of North American boreal and subalpine forests with anatomical and behavioural adaptations allowing it to make thousands of arboreal food caches in summer and fall that are presumably responsible for its high winter survival and late winter/early spring breeding. We used DNA fecal metabarcoding to obtain novel information on nestling diets and compiled a dataset of 662 published and unpublished direct observations or stomach contents identifications of natural foods consumed by Canada jays throughout the year. We then used detailed natural history information to make informed decisions on whether each item identified to species in the diets of winter adults and nestlings was best characterized as ‘likely cached’, ‘likely fresh’ (i.e., was available as a non-cached item when it appeared in a jay’s feces or stomach), or ‘either possible’. Of the 87 food items consumed by adults in the winter, 39% were classified as ‘likely cached’ and 6% were deemed to be ‘likely fresh’. For nestlings, 29% of 125 food items identified to species were ‘likely cached’ and 38% were ‘likely fresh’. Our results support both the indispensability of cached food for Canada jay winter survival and previous suggestions that cached food is important for late winter/early spring breeding. Our work highlights the value of combining metabarcoding, stomach contents analysis, and direct observations to determine the cached vs. non-cached origins of consumed food items and the identity of food caches, some of which could be especially vulnerable to degradation through climate change.
PCA-Chain: A Novel Medical Image Retrieval Blockchain
Authors: Yadav Abhay Kumar , Vishwakarma Virendra P.
Published: April 2024

For decades data security has remained a challenging task for researchers. The unrivaled immutability of blockchain data and the decentralized nature of its ledger have been put forward as potential solutions to the issue. Blockchain has been proven to be effective in securely storing textual data, however, it is unable to store image files. Researchers are now focusing on implementing blockchain for storing and securing image data as images contain a large amount of sensitive data and are prone to data tampering attacks. The proposed PCA-Chain is a novel approach to providing a secure image- based blockchain using Principal Component Analysis (PCA) to compress digital leukemia images and propagate them on blockchain via simple hash functions and retrieve them back to their original size without major compression losses. Performance evaluation was conducted using MSE, PSNR and SSIMs performance parameters. PCA-Chain provides lossless compression and can be used for the storage of medical images.
Az iskolai önakadályozást befolyásoló tényezők fiatal felnőttek körében
Authors: Horányi Virág , Jámbori Szilvia
Published: April 2024

Az önakadályozás egy olyan nem tudatos védekezési mechanizmus, melyet teljesítményhelyzetek előtt használhatunk. Megvédi énünket és társas megítélésünket azáltal, hogy elhomályosítja a teljesítményünk és a képességeink közötti kapcsolatot. Kutatásunkban arra a kérdésre kerestük a választ, hogy az iskolai önakadályozás milyen összefüggést mutat a mindset, az énhatékonyság, a célorientáció és a társas támogatás mértékével a magyar fiatal felnőttek körében. A vizsgálatban összesen 120 fő vett részt a 18 és 28 év közötti korosztályból (M = 21,82, SD = 2,05 év). A vizsgálati személyek öt kérdőívet töltöttek ki online, kényelmi mintavételi módszerrel. Ezek az SHS-H Önakadályozás skála, a Mindset kérdőív, a Célorientációs kérdőív, az Énhatékonyság kérdőív és a Multidimenzionális Észlelt Társas Támogatás kérdőívek voltak. Eredményeink azt mutatták, hogy a társas támogatás, az énhatékonyság és a teljesítménykereső elsajátítási célok megléte szignifikánsan negatív kapcsolatot mutat az önakadályozás használatával. Ezzel szemben a teljesítménykerülő elsajátítási célok szignifikánsan pozitív összefüggést mutattak az önakadályozással. A célorientáció másik két típusa, valamint a fejlődési és az rögzült mindset esetében nem volt látható szignifikáns összefüggés.
Edpidemiology, Clinical Profile and Short- Term Outcome of Hypertensive Crisis in N'Djamena (Chad)
Authors: Temoua Naibé Dangwe , Urbain Houba Dallah Tchimby , Zacharia Zakaria Abdelmadjid , Estelle Djangde Ndarwadjigue , Amine Adjougoulta Koboy Allah , Lucien Allawaye , Ahmat Adam Ali , Oumar Mahamat-Azaki , Dikoua Binwe , Narcisse Douné , Hiby Langtar Mianrho , Nahodjide Djimadoum , Joel Bamouni , Mouanodji Mbaissouroum , Patrice Zabsonré
Published: April 2024

Objective
Hypertensive crisis is an increasingly frequent medical condition in our context. Its management in medical emergencies is a real challenge for physicians. Few data on hypertensive crisis are available in Chad. The aim of this study was to investigate the epidemiological, clinical and prognostic characteristics of hypertensive crisis in the medical emergency department of Reference National Teaching Hospital in N'Djamena.

Patient and methods
This was a prospective cohort study running from 1er March 2020 to October 31 2020. Patients presenting with a sudden and severe rise in blood pressure (systolic ≥ 180 mmHg and/or diastolic ≥ 110 mmHg) with or without acute target-organs damage, had been consecutively included and followed up over a period of one (01) month. Epidemic and clinical characteristics on admission, and morbidity and mortality parameters during the course of the disease were collected. The Kaplan-Meier method and the Cox model were used to analyze survival and factors associated with death, with a significance level of p<0.05.

Results
Of the 3978 hypertensive patients admitted to medical emergencies, 252 had a hypertensive crisis, i.e. a prevalence of 6.3%. Two hundred and seventeen (217) patients were included in the study, divided into 149 cases (69%) of hypertensive emergency and 67 cases (31%) of hypertensive hypertensive urgencies. The mean age of the patients was 55.2 ± 14 years (20 and 80 years) and 67% were male. Hypertension was known in 138 patients (64%). At least one complication was present on admission in 69% of patients. Complications were classified as cardiac (50.7%), neurological (38.2%), kidney impairment (46.5%) and ocular (46.1%). The average number of antihypertensive drugs used was 2 ± 0.83 1, 4. Calcium antagonists (86.5%), diuretics (35.5%), converting enzyme inhibitors or angiotensin II receptor antagonists (33.3%) and betablockers (18%) were the pharmacological classes prescribed. Good compliance during follow-up was observed in 124 patients. One-month survival was 84% for all patients, with a 16% mortality rate. Factors associated with death were the duration of hypertension, and the occurrence of cardiovascular, renal dysfunction and ocular disease (p < 0.05).

Conclusion
Hypertensive crisis is a frequent pathology in sub-Saharan Africa, with high morbidity and mortality. Prevention requires early detection and effective management of hypertension.
Autoficção, filosofia e cultura literária: intervenções do Ecce homo, de Friedrich Nietzsche, e do Testo junkie, de Paul B. Preciado
Authors: Herkenhoff Coelho Moura Gabriel
Published: April 2024

Este artigo objetiva discutir o tema da autoficção e apresentar a possibilidade de utilizá-lo para a interpretação de obras filosóficas, destacadamente o livro Ecce homo de Friedrich Nietzsche e, secundariamente, Testo junkie de Paul B. Preciado. Para tanto, primeiro, abordarei a relação entre filosofia e literatura no contexto que alguns pensadores contemporâneos têm nomeado cultura literária. Em um segundo momento, traçarei uma breve história da formação da noção de autoficção e da consolidação do termo para demarcar um subgênero literário. Em seguida, apresentarei elementos de Ecce homo que me parecem permitir enquadrá- lo no campo da autoficção. Na última parte, serão retomadas as articulações entre literatura e filosofia, analisando- se brevemente um exemplar de autoficção no pensamento contemporâneo, Testo junkie, para sugerir que a aproximação de tal subgênero contribui para a compreensão tanto do lugar da filosofia na cultura literária quanto aspectos de nosso tempo.