bluuebunny/crossref_metadata_2025 huggingface dataset:
РЕЗУЛЬТАТЫ КРАТКОСРОЧНОГО МОНИТОРИНГА СОДЕРЖАНИЯ ГЕЛИЯ И ОБОБЩЕННЫХ ПОКАЗАТЕЛЕЙ В ПОДЗЕМНЫХ ВОДАХ ГОРНОГО АЛТАЯ
Authors: Дутова Екатерина Матвеевна , Кац Валентина Елизаровна , Шитов Александр Викторович , Сурнин Алексей Иванович , Драчев Сергей Сергеевич
Published: October 2022

Актуальность работы обусловлена необходимостью совершенствования методов мониторинга характеристик подземных вод и их изменений в сейсмоактивных районах Республики Алтай. Подземные воды являются индикатором сейсмических процессов и реагируют на изменения напряженно-деформированного состояния горных пород в зонах очагов предстоящих тектонических землетрясений. Целью: выявление краткосрочных изменений содержания гелия и обобщенных гидрогеохимических показателей в высоко динамичных объектах мониторинга подземных вод Республики Алтай для поиска предвестников сильных сейсмических событий. Методы. В основу работы положены результаты ежесуточного мониторинга подземных вод на территории Республики Алтай, который осуществлялся в январе–феврале 2021 г. на пунктах наблюдения за температурным режимами и качественным составом подземных вод – скважина и колонка – Горно-Алтайского отделения «Сибирского регионального центра Государственного мониторинга состояния недр». Результаты. Впервые на территории Горного Алтая было проведено изучение динамики гидрогеохимических характеристик и содержания гелия в подземных водах и показаны кратковременные (1–3 сутки) изменения данных характеристик в связи с землетрясениями. Для проведения данных исследований были взяты две точки мониторинга подземных вод, расположенные в г. Горно-Алтайске (колонка) и с. Старый Бельтир (скважина), удаленные друг от друга на расстояние более 200 км. Данные точки мониторинга были выбраны в связи с тем, что там было зафиксировано существенное изменение характеристик подземных вод при подготовке и протекании сейсмических событий в регионе. В работе дана характеристика сейсмического режима Алтае-Саянского региона в период мониторинга. Для выявления динамики содержания гелия и гидрогеохимических характеристик подземных вод нами было начато изучение этих характеристик в период 14.01–23.02.2021 г. Показано, что точка мониторинга Старый Белтир, расположенная в разломной зоне вблизи эпицентральной зоны Чуйского землетрясения (2003 г.) характеризуется высокой чувствительностью изменения не только гидрогеохимических характеристик подземных вод, но и высоким реагированием динамики содержания гелия на землетрясения. В результате исследований было выявлено, что Монгольское землетрясение (2021 г.) не оказало влияния на гидрогеохимический состав изучаемых пунктов мониторинга, расположенных на территории Горного Алтая, в то же время в представленных пунктах мониторинга подземных вод отражаются ближайшие к ним сейсмические события. Выбранные пункты мониторинга в ряде случаев не перекрывают друг друга и реагируют в основном на ближайшие к ним землетрясения, в том числе и на слабые. Наиболее динамичная реакция на землетрясения отмечена у гелия, pH, Eh, температуры.
Morphometry of Hip Joint in German Shepherd Dogs with Hip Dysplasia vis-a-vis Normal Hip
Authors: Kataru Jagan Mohan Reddy , Podarala Veena , Venkata Suresh Kumar Rayadurgam , Mukku Shanthi Lakshmi , Jampala Veda Samhitha
Published: October 2022

Background: Data on measurements of the proximal femur, acetabulum with special reference to CHD in GSD is relatively limited. The present study recorded the complete canine femoral geometry of healthy as well as dysplastic hip joint in young dogs of GSD breed. Methods: All the dogs were subjected to radiographic evaluation to measure hip joint morphometric parameters using the CARESTREAM vita flex CR system with added IMAGE SUITE software version 4.0. Result: In dogs below 6 months of age and with CHD, measurements like AW, HD were higher in CHD where as ND, FIA values were lower. AA, EAA values were higher and AHI was lower in CHD. Indices like DI and SI were higher whereas PC and NA were lower in CHD. In healthy hip, HNI and PC values were higher in male dogs where as FNALa, ND values were higher in female dogs. In CHD, FSC, HD, TW, FSD, FIA were higher in female dogs where as HAL value was higher in male dogs. In dogs between 6 to 12 months age and with CHD, FNALa, FNALb values were higher, where as AW, ND, FSD, FIA values were lower in CHD. AA, EAA values were higher, where as AHI, PC were lower in CHD. Indices like DI and SI were higher, whereas PC and NA were lower in CHD. In dogs with healthy hip, FNALa, FNALb, TW, AHI values were higher in male dogs where as AW, AHI values were higher in female dogs. In CHD, AW, TW were higher in female dogs where as HAL, FSC, ND, FSD values were higher in male dogs.
Tingkat Pencemaran Berdasarkan Angka Lempeng Total Bakteri pada Limbah Peternakan Babi di Kabupaten Badung, Bali
Authors: Ximenes Zelia , Suada I Ketut , Sukada I Made
Published: October 2022

Usaha peternakan babi telah menjadi sumber pendapatan bagi masyarakat pedesaan.Limbah kotoran ternak babi dapat menimbulkan masalah pencemaran lingkungan jika tidak dikelola dengan baik. Kontaminasi mikrobapada lingkungan ternak merupakan salahsatu ancaman bagi kesehatan dan kehidupan hewan yang paling besar selama periode pemeliharaan. Tujuan dari penelitian ini adalah untuk mengetahui jumlah Angka Lempeng Total Bakteri (ALTB) yang terdapat pada limbah babi di wilayah Kabupaten Badung. Penelitian ini merupakan penelitian observasional serta pemilihanlokasi peternakan dilakukansecara purposive sampling. Lokasi pengambilan sampel di Kabupaten Badung terdiri atas Kecamatan Mengwi, Kecamatan Petang, Kecamatan Abiansemal dan Kecamatan Kuta Utara. Jumlah peternakan yang disampling di setiap kecamatan adalah tiga peternakan. Volume sampel yang diambil disetiap peternakan sebanyak 500 mL, kemudian dari tiga peternakan tersebut dilakukan komposit menjadi satu sampel. Metode yang digunakan untuk menumbuhkan bakteri pencemar yaitu menggunakan metode tuang (pour platemethod).Analisis data dalam penelitian ini dilakukan secara deskriptifkualitatif.Hasil penelitian menunjukkan bahwa terdapat Angka Lempeng Total Bakteri dalam limbah peternakan babi di Kabupaten Badung dengan jumlah bakteri pada peternakan babi di Kecamatan Mengwi sebesar 290 x 109CFU/mL, Kecamatan Petang 282 x 109CFU/mL, Kecamatan Abiansemal 245 x 109CFU/mLdan Kecamatan Kuta Utara 186 x 109CFU/mL. Berdasarkan hasil penelitian ini dapat disimpulkan bahwaair limbah peternakan babi di empat kecamatan di Kabupaten Badung mengandung bakteri pencemar dalam jumlah besar.
Laporan Kasus: Penanganan Ancylostomiosis pada Anjing Pomeranian Betina Berumur Tujuh Bulan
Authors: Widyaningsih Putu Oka , Suartha I Nyoman , Batan I Wayan
Published: October 2022

Ancylostomiosis adalah penyakit parasit yang menyebar luas pada anjing yang disebabkan oleh cacing Ancylostoma spp.Parasit ini umumnya terdapat padausus halus anjing. Seekor anjing pomeranianbetinaberumur tujuhbulan memilikikeluhan adanya diare berdarah, muntah, penurunan nafsu makan dan penurunan aktivitas fisik. Hasil pemeriksaan klinis menunjukkan kondisi anjing lemas, membran mukosa dan konjungtiva mata pucat, pemeriksaan turgorkulit lambatserta waktu pengisian kapiler (capillary refill time)yang bertambahlama.Hasil pemeriksaan hematologi rutin menunjukkan anemia mikrositik hipokromik, trombositopenia dan granulositosis. Hasil pemeriksaanmikroskopis feses secara natif menunjukkan adanya telur cacing Ancylostoma sppdiidentifikasi dengan bentuk lonjong, bercangkang tipis dengan empatmorula. Berdasarkan pemeriksaan tersebut,anjing kasus didiagnosismengalami ancylostomiosis.Terapi yangdiberikan yaitu antelmintikdengan pyrantel pamoate5 mg/kg BBq24 jamselamatigahari berturut-turut peroral (PO) dan diulangi pada hari ke-7 dan hari ke-10. Injeksi antibiotikcefotaxime20 mg/kgBBq12 jamsecara intravena(IV)selamatujuhhari. Injeksi metronidazole10 mg/kgBBq12 jam selama tujuh harisecara IV. Terapi simptomatis dengan pemberian antiemetik yaitu ondansetron 0,5 mg/kg BBq12 jamselama limaharisecara IV. Pemberian kaolin pektin sebagai gastrointestinal protectant2,5mLq12 jam selama limahariPO.Pemberian terapi cairan dengan ringer laktat30 mL/kg/jamsecara IVuntuk mengganti kekurangan cairan akibat muntah dan diare. Pada hari ke-5 pengobatan anjing kasus menunjukkan perbaikan kondisi berupa perubahan tingkah laku menjadi lebih aktif dan peningkatan nafsu makan.
Kajian Pustaka: Gambaran Diagnostik dan Penanganan Obstruksi Esofaguspada Ternak Kerbau
Authors: Prasetyawan Putu  Angga , Lewinsky Monica , Nafis Abdul , Yustisia Anggia , Mirahsanti Ni Putu Nicky , Tiasnitha Ni Made Wirani Ari , Batan I Wayan
Published: October 2022

Obstruksi esofagus adalah suatu kondisi abnormal akibatterjadi penyumbatan pada esofagus. Umumnya kerongkongan tersumbatinijarang terjadi pada ruminansia besarseperti kerbau. Penyumbatan pada esofagus dapat disebabkan oleh tertelannya benda asing, striktura, maupun massajaringan. Penyumbatan esofagus yang telah lama terjadi dapat menyebabkan bloatpada penderita karena hewansulit untuk melakukan eruktasi gas yang umum dilakukan ruminansia besar. Tandaklinis yang diderita hewan berbeda-beda berdasarkan penyebabnya, namun tandaklinis yang umum ditemukanialah hewan terlihat hipersalivasi, menjulurkan lehernya, regurgitasi pakan melalui lubanghidung, penurunan nafsu makan hingga anoreksia.Tiga dari enam kasus kerbau yang dibahas, peneguhan diagnosis dilakukan dengan pemeriksaan radiografi.Hasil pemeriksaan radiografi umumnya adalah adanya massa obstruktif di daerah servikalisesofagus. Penanganan pada kasus obstruksi esofagus adalah mendorong massa obstruktifsecara manual dengan alat probang atau dengan pembedahan. Pada keenam kasus yang dilaporkan,penanganandilakukan dengan pembedahan. Pengobatan pascaoperasi, pasien diberikan antibiotik sepertienrofloxacilin, streptopenicillin, serta meloxicam.
Laporan Kasus: Batu Kantung Kemih (Cystolithiasis) yang Menimbulkan Kencing Berdarah pada Anjing Peranakan Corgy Betina Dewasa
Authors: Mariyana Lilik Dwi , Takariyanti Dzikri Nurma'rifah , Erawan I Gusti Made Krisna , Suartha I Nyoman
Published: October 2022

Cystolithiasis merupakan adanya urolith atau kalkuli di dalam kantung kemih. Cystolithiasis terjadi pada 0,4-2% dari populasi anjing. Seekor anjing peranakan Corgy betina berusia tujuh tahun, bobot badan 13,8 kg diperiksa di Healthy Pet Veterinary Clinic, dengan keluhan urin disertai darah (hematuria) namun tidak intens selama dua minggu. Pada pemeriksaan sistem urogenital menunjukkan adanya distensi abdomen dan ketika dipalpasi anjing menunjukkan respons nyeri pada bagian abdomen. Pemeriksaan ultrasonografi menunjukkan adanya urolith seperti butiran pasir dan penebalan dinding kantung kemih. Pada pemeriksaan penunjang hematologi rutin menunjukkan hasil leukositosis, limfositosis, anemia normositik normokromik dan penurunan hematrokit. Pemeriksaan mikroskopis sedimentasi urin mengkonfirmasi adanya kristal struvit. Anjing didiagnosis menderita cystolithiasis akibat struvit. Anjing kasus diterapi dengan antibiotik Ciprofloxacin HCL 10 mg/kg BB, q24h selama tujuh hari, anti radang Meloxicam 0,2 mg/kg BB, q24h selama tujuh hari, dan kapsul kejibeling satu kapsul, q24h selama tujuh hari. Setelah pengobatan selama tujuh hari, kondisi anjing mulai membaik, saat urinasi tidak adanya indikasi rasa nyeri dan tidak adanya hematuria.
Online listening strategy instruction in teaching Turkish as an L2
Authors: SEFER Ayşegül , BENZER Ahmet
Published: October 2022

Listening strategies are enacted plans that one can use to better understand, learn, remember, and comprehend a target language. The present study aims to examine how the process of listening strategy instruction may be implemented in the teaching of Turkish to L2 learners. The study was a qualitative one, conducted with the action research method on an online platform, Zoom. Five Turkish L2 learners participated in the study. The results show that students used the listening strategies in various frequencies and combinations during the implementation process. Throughout the implementation process, the least used strategies were relating with prior information, performance evaluation, monitoring, and inferencing, while the most frequently used strategies were note-taking, determining keywords, translating, and prediction. The students stated that prediction, note-taking, and planning were the most useful strategies for them during the implementation process. Also, the use of authentic videos in online listening strategy instruction lessons contributed to students' learning in diverse areas of interest, particularly learning new vocabulary, and thus motivate them.
Mathematical Creativity Test (MCT) development for middle school students
Authors: BAL SEZEREL Bilge , SAK Uğur
Published: October 2022

This study presents the development of a mathematical creativity test and exploration of its psychometric properties. The study was conducted in six public schools and a high ability center between 2015 and 2018. The sample of the study included 1129 middle school students. The Mathematical Creativity Test (MCT) consists of problem posing, making conjecture, and proof subtests. Each test has two items. The scores of the MCT are composed of fluency, flexibility, and creativity quotient. For construct validity, EFA yielded a 3-factor solution, namely, problem posing, making conjecture, and proof subtests. CFA confirmed the 3-factor solution, and all fit indices were found to be good. For criterion validity, one-way ANOVA for independent samples was conducted in different classes, and it showed that there was a significant difference, and Pearson's correlation coefficient was investigated between MCT scores and the report card grades of the mathematics lesson. There was a strong and positive correlation between the two variables. The internal consistency and the interrater reliability of the test scores were high.
Como o Estado fortalece ou destrói políticas públicas?
Authors: Pinho Carlos Eduardo Santos
Published: October 2022

No cenário de crise da democracia liberal, o propósito do artigo é analisar comparativamente a política embrionária de planejamento estatal do governo Joe Biden (EUA) e o projeto deliberado de destruição de políticas públicas sob o governo de Jair Bolsonaro. Para alicerçar nosso argumento foi mobilizada a literatura e foi realizada coleta de evidências em jornais e relatórios. Ainda que em fase de negociação com o Congresso, Biden vem promovendo um plano trilionário de investimentos em infraestrutura atrelado à redefinição da matriz produtiva, com sustentabilidade socioambiental e taxação dos mais ricos para o financiamento do Estado de bem-estar social. Por outro lado, desprovido de qualquer visão de planejamento estratégico de longo prazo, Bolsonaro se vale de uma lógica imediatista e de um ativo intervencionismo estatal para destruir legados institucionais de políticas públicas em diversas áreas, promove completa militarização da máquina pública federal e ataca as instituições do Estado Democrático de Direito. Sem mecanismos efetivos de controle e transparência, Bolsonaro entregou o orçamento do governo federal nas mãos de um bloco de parlamentares fisiológicos (o chamado “Centrão”) em troca de apoio político. O resultado parece ser a gradual deterioração das políticas sociais universais no Brasil.
Análise estatística multivariada para estudo da percepção socioambiental em um núcleo metropolitano
Authors: Rodrigues Júnior Jocimar Coutinho , Santos Ester Milena dos , Rocha Daniella
Published: October 2022

Dentre as diversas necessidades das áreas urbanas, tem-se o acesso ao saneamento básico, que deveria ser uma das prioridades no que se refere ao planejamento urbano. Os impactos ambientais ocasionados em decorrência das deficiências de saneamento colocam em risco diversas pessoas em uma determinada localidade. O Grande Rosa Elze consiste no maior núcleo urbano do município de São Cristóvão e constitui-se como uma área que enfrenta problemas em serviços de saneamento básico em razão do desenvolvimento inadequado relacionado com a irregular prestação desses serviços. Diante dessa situação, este trabalho tem como objetivo analisar a percepção dos moradores do Grande Rosa Elze, a fim de constatar as relações das ações envolvendo os serviços de saneamento com os possíveis impactos ocasionados na área. O método utilizado para explicar esta relação consiste na ferramenta de estatística multivariada, análise de agrupamentos, que realiza a hierarquização das problemáticas apontadas. Os resultados mostraram que a falta de acesso à rede de esgotamento sanitário influencia diversos problemas na concepção da população, principalmente, problemas de alagamentos em períodos chuvosos. Diante deste estudo, é possível perceber que é de significativa importância a aplicação de mitigações que melhorem o acesso aos serviços de saneamento básico, bem como a correção prioritária de ações que ocasionam as problemáticas apontadas.
Análise da expansão urbana de Marília, São Paulo: um olhar sobre os remanescentes florestais ciliares periurbanos
Authors: Ribas Eduardo Campanhã , Biondi Daniela , Lopes Iran Jorge Corrêa , Reis Allan Rodrigo Nunho dos , Oliveira Thiago Gomes de Sousa
Published: October 2022

Devido à sua localização, a cidade de Marília, SP, encontra-se em uma região importante para o abastecimento hídrico do oeste paulista, e sua área urbana avança sobre as nascentes, sendo necessário preservar as florestas ciliares já degradadas e fragmentadas. Assim, o objetivo foi analisar temporalmente a paisagem nas regiões de interesse hídrico, com vistas a avaliar o potencial de conservação dos fragmentos florestais responsáveis por este recurso. Foi realizada uma análise temporal nos anos 1989, 1999, 2009 e 2019, a partir de imagens dos satélites Landsat 5, 7 e 8, com 30 m de resolução espacial. No programa ArcMap 10.3, o uso do solo foi agrupado em seis classes: formação florestal, plantio florestal, formação natural não florestal, agricultura, áreas não vegetadas e água. Para todo o município, foram calculadas as métricas de paisagem CA (cobertura da terra) e PLAND (proporção de cobertura da terra) para as seis classes de uso do solo. Foi realizada uma análise da cobertura florestal a partir de um buffer de 5 km no entorno da área urbana, sendo calculadas mais cinco métricas de área, borda e forma. O software Patch Analyst versão 5.2.0.16 foi utilizado para o cálculo das métricas de paisagem. As classes que mais se destacaram em tamanho de área foram agricultura (93.962,07 ha; 80,27%), formação florestal (15.682,97 ha; 13,40%) e áreas não vegetadas (5.220,63 ha; 4,46%). Os maiores aumentos proporcionais foram de plantio florestal (0,11 para 1,27 ha), água (0,02 para 0,05 ha) e áreas não vegetadas (2,17 para 4,45 ha), enquanto a agricultura perdeu área (85,73 para 80,27 ha). Houve aumento das áreas florestadas nos últimos 30 anos a partir do surgimento de fragmentos pequenos e morfologicamente frágeis; além disso, com o aumento da área urbana, aumentam-se os conflitos com os remanescentes florestais mais próximos.
CHARACTERISTICS OF CTEV PATIENTS AT ORTHOPEDIC AND TRAUMATOLOGY OUTPATIENT CLINIC IN DATU BERU GENERAL HOSPITAL TAKENGON CENTRAL ACEH PERIOD AUGUST 2018-JULY 2022
Authors: Ongko Setunggal Wibowo  , Thaib Subhan
Published: October 2022

Background: In the past decade, the endoscopic technique has been applied as a feasible and less invasive approach to orthopedic surgeries. Minimally invasive, full-endoscopic surgery has gained considerable attention in managing air gun injuries to the spine. Sacrum injuries among air gun wounds are rare and few have been published in case reports. Here, we present the management of air gun-bullet injury to the pediatric spinal spine in a 5-year-old child using endoscopic surgical intervention.Case Report: A 5-year-old girl was accidentally shot in the lower back with an air gun. The CT scan imaging shown a retained projectile in the pedicle of S1 vertebrae without vascular injury or unstable vertebral fracture. A minimally invasive, full-endoscopic surgical technique was applied to remove the bullet in this patient. On post-surgical follow-up, the patient was in a good recovery state.Discussion: Surgical intervention is needed for decompression, stabilization, and diminished risks of lead toxicity. The percutaneous endoscopic approach is the least invasive intervention performed to ensure a targeted approach through the anatomical openings of the spine and through intervertebral discs and bone structures, thereby further reducing spinal instability, blood loss, and infection risk.Conclusion: The endoscopic operation of minimally invasive surgical techniques is an effective operative approach not only limited in spinal stenosis cases, but also in air gun injuries.
GIANT CELL TUMOR OF THE PROXIMAL PHALANX OF THE INDEX FINGER OF THE HAND: A RARE CASE REPORT
Authors: Edward Mouli , Mahyudin Ferdiansyah , Basuki Muhammad Hardian , Bari Yunus Abdul , Bimoseno Caesar Haryo
Published: October 2022

Background: Giant cell tumor (GCT) of bone is a relatively common type of benign tumor involving the epiphyseal region of tubular bones, but GCT rarely occurs at hand (1–4% of all GCT). GCT within the hand tends to be more aggressive and recurs more rapidly in hand than in other locations. Most authors prefer curettage or resection with reconstruction to maintain anatomical and functional integrity.Case Report: A 27-year-old man with a chief complaint of an enlarged lump and pain in the index finger of his left hand. These lumps appeared three months ago. Plain radiographs showed lytic, eccentric, geographic lesions with well-defined borders and narrow transition zones. Magnetic resonance imaging (MRI) showed a primary aggressive bone tumor with extension to the surrounding soft tissue. Fine Needle Aspiration Biopsy (FNAB) revealed the lesion as a Bone Giant Cell Tumor. The patient then underwent local resection and reconstruction using an allograft. Range of movement (ROM) measurements and DASH scores were evaluated.Discussion: Radiographic and MRI examinations showed characteristic cortical breach, and FNAB showed multinucleated giant cell spread. After treatment, the patient was found to be pain-free, have an improved ROM, and reduced disability. There was no recurrence observed. Conclusion: Despite the tendency for hand GCT to be more aggressive, local resection and reconstruction using an allograft with adjuvant hydrogen peroxide can reduce recurrence and disability.
The Theory of Quantum Uncertainties and Quantum Measurements
Authors: Anand Harsh
Published: October 2022

1) We shall discuss what modern interpretations say about the Heisenberg's uncertainties. These interpretations explain that a quantity begins to 'lose' meaning when a conjugate property begins to 'acquire' definite meaning. We know that a quantity losing meaning means that it has no fixed value and has an uncertainty . In this paper we look deeper into this interpretation and the outcome reveals more evidence of the quantity losing meaning. Newer insights appear. 2) We consider two extreme cases of hypothetical processes nature undergoes, without interference by a measurement: One, a system collapses to an energy eigenstate under the influence of a Hamiltonian instantaneously at a time $t$. This is thus what would happen if we would measure the system's energy. Next, when a particle becomes localised to a point at a time $t_0$ under the influence of a Hamiltonian. This is thus what would happen if we would measure the system's position. We shall prove that both these situations cannot arise under ordinary circumstances and thus measurement processes cannot be modelled by physical Hamiltonians.
Tracing the Food Web of Changing Arctic Ocean: Trophic Status of Highly Abundant Fish, Gasterosteus aculeatus (L.), in the White Sea Recovered Using Stomach Content and Stable Isotope Analyses
Authors: Genelt-Yanovskaya Anna S. , Polyakova Natalia V. , Ivanov Mikhail V. , Nadtochii Ekaterina V. , Ivanova Tatiana S. , Genelt-Yanovskiy Evgeny A. , Tiunov Alexei V. , Lajus Dmitry L.
Published: October 2022

Studies of dietary preferences of migratory species are of great importance as these species connect food webs of habitats across the migration route and thus represent trophic relationships between the spatially disjointed communities. Here we describe dietary preferences of threespine stickleback G. aculeatus in the White Sea during the spawning season using stable isotope and stomach content analyses. Both analyses indicated that during the spawning season, when sticklebacks spend most of the time in the inshore, their diet significantly consist of benthic species in contrast to the start of the spawning season when fishes migrating from the offshore are feeding on zooplankton. Also, we show that stickleback eggs contribute greatly to the diet of both male and female fishes. Using Bayesian mixing modelling we show that dietary preferences in females were broader than in males, and more variable during the spawning season. Males fed on eggs almost while guarding their nests. Both stomach contents and isotope signatures demonstrate that by the end of the spawning season sticklebacks again increase consumption of plankton, and isotope analysis proved to be more reliable tool to trace this change than stomach content analysis. Our results show that stable isotope and stomach content analyses well supplement each other in understanding of seasonal changes in dietary composition of stickleback.
Point-of-Care Testing, Spatial Care Paths, and Enhanced Standards of Care – Preparing Island Communities for Global Warming and Rising Oceans
Authors: Kost Gerald , Fuzery Anna , Carataro Louie , Tinsay Samantha , Zadran Amanullah , Ybanez Adrian
Published: October 2022

Abstract: Our goal is to create point-of-care (POC) strategies that accelerate decision making, increase efficiency, improve outcomes, and enhance standards of care in island communities faced with global warming, rising oceans, population migration, and intensifying weather disasters. We assessed needs in the Bantayan Archipelago and mainland Cebu Province, Visayas Islands, Philippines, to map POC diagnostics, rescue times, and spatial care paths. Significant deficiencies were lack of cardiac troponin testing for rapid diagnosis of acute myocardial infarction, absence of blood gas and pH testing for support of critically ill patients, and geographic gaps prolonging patient transfers and delaying treatment. Strengths comprised primary care that can be facilitated by POC testing, logical inter-island transfers for which decision making and triage could be accelerated with onboard diagnostic testing, and healthcare small-world networks amenable to POC advances, such as pre-hospital testing, that avoid overloading emergency rooms. Healthcare resources must be distributed to archipelago islands, not concentrated in large metropolitan areas inaccessible for emergency interventions. We conclude that a point-of-need focus will help improve public health, decrease disparities in mortality among rural islanders versus urban dwellers, and pave the way for heightened resilience in anticipation of the adverse impact of global warming on vulnerable coastal areas.
Monogeneans from Catfishes in Lake Tanganyika. II: New Infection site, New Record, and Additional Details on the Morphology of the Male Copulatory Organ of Gyrodactylus transvaalensis Prudhoe and Hussey, 1977
Authors: Mushagalusa Mulega Archimède , Van Steenberge Maarten , Kmentová Nikol , Muterezi Bukinga Fidel , Rahmouni Imane , Masilya Pascal Mulungula , Benhoussa Abdelaziz , Pariselle Antoine , Vanhove Maarten P.M.
Published: October 2022

: The ichthyofauna of Lake Tanganyika consists of 12 families of fish of which five belong to Siluriformes (catfishes). Studies on siluriforms and their parasites in this lake are very fragmentary. The present study was carried out to help fill the knowledge gap on the monogeneans parasitizing the siluriform fishes of Lake Tanganyika in general and more particularly Clarias gariepinus. The gills of a specimen of Clarias gariepinus (Clariidae) were examined for ectoparasites. We identified the monogenean Gyrodactylus transvaalensis (Gyrodactylidae). This is the first time this parasite was found infecting gills. We are the first to observe a large spine in the male copulatory organ of this species, and to provide measurements of its genital spines; this completes the description of the male copulatory organ which is important in standard monogenean identification. This is the first monogenean species reported on C. gariepinus at Lake Tanganyika and the third known species on a representative of Siluriformes of this lake. It brings the total number of species of Gyrodactylus recorded in Lake Tanganyika to four. Knowing that other locations where this species has been reported are geographically remote from Lake Tanganyika, we propose a “failure to diverge” phenomenon for G. transvaalensis.
Leveraging Computer Vision Application in Visual Arts: A Case Study on the Use of Residual Neural Network to Classify and Analyze Baroque Paintings
Authors: Kvak Daniel
Published: October 2022

With the increasing availability of large digitized fine art collections, automated analysis and classification of paintings is becoming an interesting area of research. However, due to domain specificity, implicit subjectivity, and pervasive nuances that vaguely separate art movements, analyzing art using machine learning techniques poses significant challenges. Residual networks, or variants thereof, are one the most popular tools for image classification tasks, which can extract relevant features for well-defined classes. In this case study, we focus on the classification of a selected painting 'Portrait of the Painter Charles Bruni' by Johann Kupetzky and the analysis of the performance of the proposed classifier. We show that the features extracted during residual network training can be useful for image retrieval within search systems in online art collections.
The Tumor Microenvironment in Tumorigenesis and Therapy Resistance Revisited
Authors: Dzobo Kevin , Senthebane Dimakatso , Dandara Collet
Published: October 2022

Tumorigenesis is a complex and dynamic process involving cell-cell and cell-extracellular matrix (ECM) interactions that allow tumor cell growth, drug resistance and metastasis. This review provides an updated summary of the role played by the tumor microenvironment (TME) components and hypoxia in tumorigenesis and highlight various ways through which tumor cells reprogram normal cells including into phenotypes that are pro-tumorigenic including cancer associated- fibroblasts, -macrophages and -endothelial cells. Tumor cells secrete numerous factors leading to transformation of a previously anti-tumorigenic environment into a pro-tumorigenic environment. Once formed, solid tumors continue to interact with various stromal cells including local and infiltrating fibroblasts, macrophages, mesenchymal stem cells, endothelial cells, pericytes, and secreted factors and the ECM within the tumor microenvironment (TME). The TME is key to tumorigenesis, drug response and treatment outcome. Importantly, stromal cells and secreted factors can initially be anti-tumorigenic but over time promote tumorigenesis and induce therapy resistance. To counter hypoxia, increased angiogenesis leads to formation of new vascular networks in order to actively promote and sustain tumor growth via supply of oxygen and nutrients whilst removing metabolic waste. Angiogenic vascular network formation aid in tumor cell metastatic dissemination. Successful tumor treatment and novel drug development require the identification and therapeutic targeting of pro-tumorigenic components of the TME including cancer-associated- fibroblasts (CAFs) and -macrophages (CAMs), hypoxia, blocking ECM-receptor interactions, in addition to targeting of tumor cells. Re-programming of stromal cells and the immune response to be anti-tumorigenic is key to therapeutic success. Lastly, this review highlights potential TME- and hypoxia-centred therapies under investigations.
Impact of Metabolic Stress on BeWo Syncytiotrophoblast Function
Authors: Rogers Lisa , Huggins Marissa , Doster Ryan , Omage Joel , Eastman Alison , Aronoff David M.
Published: October 2022

Background: During placental formation, cytotrophoblasts (CTBs) fuse into multinucleate, microvilli-coated syncytiotrophoblasts (STBs), which contact maternal blood, mediating nutrient, metabolite, and gas exchange between mother and fetus, and providing a barrier against fetal infection. Trophoblasts remodel the surrounding extracellular matrix through the secretion of matrix metalloproteinases (MMPs). Maternal obesity and diabetes mellitus can negatively impact fetal development and may impair trophoblast function. We sought to model the impact of metabolic stress on STB function by examining MMP and hormone secretion. Methods: The BeWo CTB cell line was syncytialized to STB-like cells with forskolin. Cell morphology was examined by electron microscopy and immunofluorescence; phenotype was further assessed by ELISA and RT-qPCR. STBs were exposed to a metabolic stress cocktail (MetaC: 30 mM glucose, 10 nM insulin, and 0.1 mM palmitic acid). Results: BeWo syncytialization was demonstrated by increased secretion of HCGβ and progesterone, elevated syncytin gene expression (ERVW-1 and ERVFRD-1), loss of tight junctions, and increased surface microvilli. MetaC suppressed HCGβ and progesterone and altered both MMP-9 and MMP-2. Conclusions: Metabolic stress modeling diabetes and obesity altered BeWo STB hormone and MMP production in vitro. These results compel further study into the potential impact of metabolic stress on trophoblast formation and function.
Effect of Electron-Beam Induced Nanostructuring on Surface Properties and Radioluminescence of ZnS:Cu,Br Phosphors
Authors: Zelenina Elena Vladimirovna , Bakhmetyev Vadim , Sychov Maxim Maximovich
Published: October 2022

Electron beam treatment of ZnS:Cu,Br (Cu activator content 0…0.6%wt.) radioluminescent phosphors as well as charge mixture with the electron energy 900 keV and absorbed dose of 600 kGy resulted in a enhancement of brightness up to 80%. The increased brightness is due to increase of content of wurtzite phase relative to sphalerite one with formation of wurtzite/sphalerite nanocomposite structure. Transformation of crystal structure is accompanied with corresponding change in content of active surface centers characteristic for sphalerite and wurtzite phases. A model describing surface centers of ZnS:Cu,Br radioluminescent phosphor is suggested.
An Overlooked Hepcidin-cadmium Connection
Authors: Płonka Dawid , Wiśniewska Marta D. , Peris-Díaz Manuel D , Krężel Artur , Bonna Arkadiusz M. , Bal Wojciech
Published: October 2022

Hepcidin (DTHFPICIFCCGCCHRSKCGMCCKT), an iron regulatory hormone is a 25 amino acid peptide with 4 intramolecular disulfide bonds, circulating in blood. Its hormonal activity is indirect and consists of marking ferroportin-1 (an iron exporter) for degradation. Hepcidin biosynthesis involves N-terminally extended precursors prepro-hepcidin and pro-hepcidin, processed by peptidases to the final 25-peptide form. A sequence-specific formation of disulfide bonds and export of the oxidized peptide to the bloodstream follows. In this study we considered the fact that prior to export, reduced hepcidin may function as an octathiol ligand bearing some resemblance to the N-terminal part of α-domain of metallothioneins. Consequently, we studied its ability to bind Zn(II) and Cd(II) ions using the original peptide and a model for prohepcidin, extended N-terminally with a stretch of five arginine residues (5R-hepcidin). We found that both form equivalent mononuclear complexes with two Zn(II) or Cd(II) ions saturating all eight Cys residues. The average affinity at pH 7.4, determined from pH-metric spectroscopic titrations, is 1010.1 M-1 for Zn(II) ions, the Cd(II) ions bind with affinities of 1015.2 M-1 and 1014.1 M-1. Using mass spectrometry and 5R-hepcidin we demonstrated that hepcidin can compete for Cd(II) ions with metallothionein-2, a cellular cadmium target. These studied empowered us to conclude that hepcidin binds Zn(II) and Cd(II) sufficiently strongly to participate in zinc physiology and cadmium toxicity under intracellular conditions.
Phenylbenzohydrazides Obtained from Isatoic Anhydride Present Anti-Inflammatory Activity in Vivo and in Vitro
Authors: Paiva João Pedro Barros de , Cordeiro Millena Santos , França Patricia Ribeiro de Carvalho , Branco Luiz Octavio Pereira , Santos Isabela Souza dos , Reis Nanashara Figueiredo , Pimentel Patrick Pedro , Giorno Thais Biondino Sardella , Lima Evanoel Crizanto de , Fernandes Patricia Dias
Published: October 2022

Background: Despite the existence of a wide variety of anti-inflammatory drugs, the vast majority are classified as steroidal or non-steroidal. Both classes with many side effects that limit usage. Thus, the search for new molecules with anti-inflammatory potential is still important. Methods: Five phenylbenzohydrazides were synthetized and evaluated in pre-clinical models of acute inflammation in vivo and in vitro. Results: Substances significantly reduced cell migration induced by carrageenan. It was also observed an intense inhibition in protein extravasation and cytokines (IL-6, IL-1β, and TNF-α) production as well as nitric oxide reduction. INL-11 demonstrated to be the most potent since the reduction was significant even when compared with dexamethasone. In vitro INLs also reduced cytokines and NO production and iNOS activity. INL-11 was the most effective in reducing cell migration in vitro. Conclusions: our data suggest that these substances are suitable for further development to new series of compounds that could lead to new hits and future drug prototypes for anti-inflammatory conditions.
Increasing Evidence of Impaired Team Mindfulness in Online Academic Meetings Intended to Reduce Burnout
Authors: Nash Carol
Published: October 2022

Burnout, a negative job-related psychological state particularly associated with the health professions, equates to a loss of valuable research in healthcare researchers. Team mindfulness, recognized to enhance personal fulfilment through work engagement, represents one important aspect found effective in reducing burnout. In a specific series of diverse membership academic meetings intended to reduce research burnout—employing writing prompts, doodling and continuous developmental feedback to do so—team mindfulness was demonstrated when conducted in person. Therefore, determining if team mindfulness is evident when holding such academic meetings online is relevant. When COVID-19 limitations required moving these academic meetings online, it was previously noted and reported that team mindfulness was affected in no longer being present during the first eighteen months of restrictions. To discover if this result persisted, question asking, doodles submitted and feedback responses were analyzed of the following year’s academic meetings for the same group, both quantitively and qualitatively. In finding the team mindfulness of these meetings additionally compromised the second full year, online practices actually found successful at creating and supporting team mindfulness—online games—are identified and considered. Concluding implications are noted and recommendations made regarding team mindfulness in reducing burnout for future online academic meetings.
Temporal Dissection of Altered Pathways during the Evolution of Cancer
Authors: Ahrenfeldt Johanne , Christensen Ditte S. , Sokač Mateo , Kisistók Judit , McGranahan Nicholas , Birkbak Nicolai J.
Published: October 2022

: Cancer metastasis is the lethal developmental step in cancer, responsible for the majority of cancer deaths. To metastasize, cancer cells must acquire the ability to disseminate systemically and to escape an activated immune response. Here, we endeavoured to investigate if metastatic dissemination reflects acquisition of genomic traits that are selected for. We acquired mutation and copy number data from 8,332 tumours representing 19 cancer types acquired from The Cancer Genome Atlas and the Hartwig Medical Foundation. A total of 827,344 non-synonymous mutations across 8,332 tumour samples representing 19 cancer types were timed as early or late relative to copy number alterations, and potential driver events were annotated. We found that metastatic cancers had significantly higher proportion of clonal mutations and a general enrichment of early mutations in p53 and RTK/KRAS pathways. However, while individual pathways demonstrated a clear time-separated preference for specific events, the relative timing did not vary between primary and metastatic cancers. These results indicate that the selective pressure that drives cancer development does not change dramatically between primary and metastatic cancer on a genomic level, and is mainly focused on alterations that increase proliferation.
High Seroprevalence of Anti-SARS-CoV-2 Antibodies in Children in Vietnam: An Observational, Hospital-based Study
Authors: Tran Dien Minh , Vu Uyen Tu , Hoang Canh Ngoc , Nguyen Ha Thu Thi , Nguyen Phu Huy , Tran Mai Chi Thi , Chu Anh Ngoc , Phan Phuc Huu
Published: October 2022

Background: The robustness of sero-surveillence has delineated the high burden of SARS-CoV-2 infection in children; however, these existing data showed wide variation. This study aimed to identify the serostatus of antibodies against SARS-CoV-2 and associated factors among children following the fourth pandemic wave in Vietnam. Methods: A cross-sectional study was conducted at Vietnam National Children’s Hospital (VNCH) between March 13 and April 3, 2022. 4,032 eligible children seeking medical care for any medical condition not related to acute Covid-19 infections was tested for IgG SARS-CoV-2 Antibodies by ADVIA Centaur® SARS-CoV-2 IgG (sCOVG) assay using the residuals of routine blood samples. Results: The median age of enrolled children was 39 (IQR=14-82) months. The overall seropositive prevalence was 59.2%, and the median antibody titer was 4.78 [IQR 2.38-9.57] UI/mL. The risk of seropositivity and the median antibody titer was not related to gender (58.6% versus 60.1%, 4.9 versus 4.6 UI/mL, all p>0.05). Among age groups, the highest seroprevalence was reported in the children aged 13 to <36 months old. Children aged ≤12 months were likely to be seropositive compared to children aged 36 to <60 months (59.2% versus 57.5%, p=0.49) and those aged ≥144 months (59.2% versus 65.5%, p=0.16). Children aged ≥144 months exhibited a significantly higher titer of protective COVID-19 antibodies than other age groups (p <0.001). In multivariate logistic regression, we observed independent factors associated with SARS-CoV-2 seropositivity, including the age 13 to <36 months (OR=1.29, 95%CI=1.06-1.56, p=0.01), 60 to <144 months (OR=79, 95%CI=0.67-0.95, p=0.01), ≥144 months (OR=1.84, 95%CI=1.21-2.8, p=0.005), the presence of infected household members (OR=2.36, 95%CI=2.06–2.70, p<0.001), participants from Hanoi (OR=1.54, 95%CI=1.34-1.77, p<0.001), underlying conditions (OR=0.71, 95%CI=0.60-0.85, p<=0.001), and using corticosteroids or immunosuppressants (OR=0.64, 95%CI=0.48-0.86, p=0.003). Conclusions: This study highlights a high seroprevalence of antibodies against SARS-CoV-2 among children seeking medical care for non-COVID-19-related conditions in a tertiary children’s hospital in Hanoi, Vietnam. In the context of reopening in-person schools and future emerged COVID-19 variants, this point will also be a key message about the necessity of “rush-out” immunization coverage for children, especially those under the age of three years.
What is the Role of T.E.A Concept Between Positive Recommendation and Behavioural Intention to Purchase in Social Media?
Authors: Tun Phyo Min
Published: October 2022

Research Aims: This study explores the antecedents of customers’ behavioural intention to purchase on the social media platform. In addition, the T.E.A concept, the group of consequences of positive recommendation (PR), is developed by amalgamating trust (T), easiness (E), and amusement (A). Design/Methodology/Approach: The data was collected from 260 random social media users from Myanmar. Both exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were employed to examine the observed variables, and structural equation modelling (SEM) techniques were used to estimate the hypotheses in AMOS software. Research Findings: The results disclose that the T.E.A concept is fully mediating between positive recommendation and customers’ purchase intention. Theoretical Contribution/Originality: This study gives clear direction for future research studies, notably, in the online shopping context by providing the T.E.A concept. Managerial Implication in the South East Asian Context: The retailers on social media develop effective marketing strategies based on T.E.A concept to attract more customers, especially from South East Asian countries. Research Limitations & Implications: The vivid limitation of this study is focusing on only the positive recommendation as an antecedent of the T.E.A concept and the findings of this study implicate both theoretically and practically the future research studies about customers’ behaviour in the online shopping context.
The Role of Leaders' Motivation, Entrepreneurial Leadership, and Organisational Agility in Social Enterprise Sustainability
Authors: Jan Brian Karno , Maulida Mira
Published: October 2022

Research Aims: Expand the insights for social enterprises (SEs) to sustain their economic and social performance, considering the impact of leader’s motivation, entrepreneurial leadership, organisational agility, and competitive advantage. Design/Methodology/Approach: The dataset was obtained from a survey of 102 SE strategic leaders in Indonesia, which was processed using PLS and SEM to test the hypothesis. Research Findings: Motivation has a positive effect on entrepreneurial leadership but not on organisational agility. Entrepreneurial leadership has tridirectionally relationships with organisational agility, competitive advantage, and social firm performance. Organisational agility has bidirectional relationships with competitive advantage and economic firm performance, whereas competitive advantage only positively affects social firm performance. Theoretical Contribution/Originality: Illuminated a way for SEs to improve economic and social performance by making several variables as a unit. So that SEs know where to put their focus and the impact of the decisions and steps they take. This study also paved the way for researchers to determine future research topics that must be explored. Managerial Implication in the South East Asian Context: As insights for SE leaders in making decisions and finding solutions to the challenges or problems they face while contributing to the development of organisational performance in terms of economic and social. Research Limitations & Implications: This study is a descriptive, cross-sectional study that only analyses Indonesian SEs. Therefore, this study's results only represent SE conditions at the specific time of this research.
The Effect Of Teacher Stress On Teacher Well-Being In Teachers Who Teach On Inclusive Elementary School
Authors: Issom Fitri Lestari , Fachrurozzy
Published: October 2022

This research aims to find effects of teachers’ stress on teacher well-being in teachers of inclusive elementary schools. This is a quantitative research with one predictor linear regression analysis. Samples in this research were 117 inclusive elementary schools collected using the accidental sampling. Variable of teachers’ stress was measured using Teacher Stress Inventory (TSI) developed by Collie and variable of teacher well-being was measured using Teacher Well-Being Scale (TWBS) developed by Firman & Fastenau. The research results showed significance value (ρ) OG 0.000, which was smaller than 0.5, and it was found that F-count was 29.795 and F-table was 3.92. It meant that teachers’ stress provided significant effects on teacher well-being in teachers of inclusive elementary schools. This study concluded that if teachers experience high levels of stress, it will reduce their level of teacher well-being.  In addition, it was found that R-square was 0.206, which meant that teachers’ stress provided effect of 20.6% on teacher well-being in teachers of inclusive elementary schools.