bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Marketing Mix on Perceived Value, Destination Image and Loyalty of Tourists (Case Study: Khalkhal City, Iran)
Authors: Esmaili Saeideh , Rezaei Nafiseh , Abbasi Reza , Eskandari Samane
Published: November 2017

This study examines the relationship between marketing mix with loyalty, perceived value, perceived quality and destination image. This is an applied descriptive study the aim of which is to determine the impact of marketing mix of services (Product, Pricing, Place, Promotion, People, Process and Physical Evidence) on perceived quality, loyalty, perceived value and destination image of the tourists in Khalkhal city, Iran. Population of the study included all the tourists visiting Khalkhal city from among whom 385 respondents participated in this study. A questionnaire was used for data collection. The conceptual model was analyzed based on linear regression analysis in SPSS software and model fitness was analyzed using LISERL software. Cronbach’s alpha of the questionnaire was equal to 0.791 that is higher than 0.7 and so reliability of the questionnaire was acceptable. Findings of the study showed that promotion, people and physical evidences had the highest effect on perceived value, destination image and perceived quality. Finally, some suggestions were provided for the managers of the tourism destinations to improve the perceived value and quality and also develop a proper destination image.
Kilka uwag o znajomości dzieła Jana Jakuba Rousseau „Emil, czyli o wychowaniu” w Polsce przełomu XVIII i XIX wieku
Authors: Żołądź-Strzelczyk Dorota
Published: November 2017

“Émile, in other words – about upbringing”, the work by J.J. Rousseau published in 1762 was read relatively soon in Poland, and for a long time in French. We can see traces of “Emil” both in the memoirs of the late eighteenth and early nineteenth centuries, as well as in novels. Among the former, particularly interesting are the memoirs of women – Henrieta z Działyńskich Błędowska and Wiridianna Fiszerowa. They describe the upbringing practices of their childhood and also how they brought up their own children. By analyzing these memories one can see that the attitude towards Rousseau’s concept of upbringing was different: some have used his recommendations, and others criticized them. In the second group of sources one should mention the works of Ignacy Krasicki, Dymitr Michał Krajewski, or Fryderyk Skarbek, in which there are also references to upbringing and the human model described in the work of Rousseau.
Jean-Jacques Rousseau and his ideas in the spectrum of the pressing challenges of our time: to the postulates of modern psychological and pedagogical interaction
Authors: Manokha Irina
Published: November 2017

The personality and creativity of Jean-Jacques Rousseau are multifaceted, sometimes difficult to structure and observe in modern humanistic theorizations, although the idea of a special social function of personal sovereignty and the idea of history as a meaningful synthesis of historical facts have not lost their relevance today, if we find the necessary range of review and ways of implementation. Another example – the idea of education as a system, which should be the very nature – the nature of the pupil, the “nature-loving” educator, and the natural educational process itself. If we consider the idea of following the natural pupil so as to create conditions for detection, disclosure, and facilitating the full deployment of the individual capacities of the pupil, this idea is at least highly relevant. This is an aspect of the modern psychological, pedagogical, and even – political – mainstream, the focus of what is most concerned about contemporary human society and its various institutions. If we consider that the idea of naturalness facilitates the educational process as a way of bringing it closer to some “maieutic” ideal – it is also one of the centrifugal issues of modern pedagogy and educational affairs in general, the question – how to make the process – non-violent, opening prospects, and not prevent them from forming the ability to independently explore the world and find ways of acting effectively in it. If we treat the idea of the “nature-loving” educator as subtly and carefully acting in relation to any of the manifestations of the pupil, thereby unleashing the potential of the tutor, is not this the way to pre-empt all types of “burn up” (both professional, and emotional) for the modern educator in the broad sense of the word – “sculptor of human souls”? In this article with the elements of an essay – the proposal is to make a fascinating excursion, full of unexpected discoveries into the world of Rousseau.
Le terme « dharma » (tib. chos) et son applicabilité dans le contexte du Dharmadharmatāvibhāga, texte bouddhique de l’Inde du ive siècle
Authors: Denis Diane
Published: November 2017

Cet article a pour objectif d’examiner le terme dharma (tib. chos) tel qu’utilisé dans un texte bouddhique de l’Inde du ive siècle, le Dharmadharmatāvibhāga. Les difficultés de traduction qu’ont eues les spécialistes jusqu’ici sont le symptôme d’un problème plus profond touchant à l’interprétation de cette notion ainsi qu’à sa fonction. On est ici devant un problème dans lequel la réflexion philosophique est en elle-même une pratique.
La naissance angoissée de l’Absolu : autour des Recherches sur l’essence de la liberté humaine et des Âges du monde de Schelling
Authors: Pelletier Étienne
Published: November 2017

Après la publication en 1809 de ses Recherches sur l’essence de la liberté humaine, Schelling s’attelle pendant plusieurs années à l’impossible projet des Âges du monde. Les deux démarches ont en commun une mise en récit de la naissance de l’Absolu hors de lui-même et l’angoisse qui l’accompagne. Après avoir exposé l’éternelle vie de l’Absolu, caractérisée par un désir angoissé vers l’être, je lie à l’angoisse la dimension narrative et l’anthropomorphisme assumé de ces écrits. Je termine en questionnant le statut mythique du récit que fait Schelling.
L’abandon chez Charles de Foucauld et Madame Guyon
Authors: Tanguay Félix
Published: November 2017

Le présent article s’interroge sur la notion d’abandon mise de l’avant dans plusieurs ouvrages de spiritualité. Plus précisément, il se penche sur l’acception du terme « abandon » chez deux mystiques chrétiens catholiques qui ont marqué l’histoire, soit Charles de Foucauld (1858-1916) et Madame Guyon (1648-1717). Par le biais de deux textes fondamentaux de ces deux auteurs et selon une grille d’analyse en trois volets (l’abandon selon la relation à soi, à Dieu et à l’autre), l’article permet de montrer que, loin d’être évidente, la notion d’abandon varie selon plusieurs facteurs et ne saurait se réduire à une seule définition. Par exemple, alors que, chez Foucauld, l’abandon tend à se traduire par une intense pratique extérieure et un appel à suivre l’exemple de Jésus, chez Guyon, l’abandon renvoie plutôt à une expérience intérieure et une volonté de partager cette expérience. La recherche permet également de déceler un trait d’union historique entre les deux mystiques, c’est-à-dire le livre L’abandon à la Providence divine. En conclusion, l’article suggère une piste de réflexion sur la notion contemporaine de l’abandon chez Alexandre Jollien.
Selected Topics on Complex Systems Informatics: Editorial Introduction to Issue 12 of CSIMQ
Authors: Sandkuhl Kurt
Published: November 2017

Modeling is an important contribution to dealing with complexity in development and engineering processes. A model is a generalized representation of a piece of reality, with only those real‐world properties included which are relevant to the purpose of modelling. Models don’t remove the complexity of the real world but help to understand it and to design and develop solutions. All articles in this issue are in some respect concerned with models or modelling.The articles in this issue also reflect recent trends in industry and society, such as digitization and industry 4.0, and show that these trends will not necessarily reduce complexity in systems but rather require the combination of proven approaches, such as modelling, and new methods for managing this complexity.
Human Performance-Aware Scheduling and Routing of a Multi-Skilled Workforce
Authors: Van Eck Maikel , Firat Murat , Nuijten Wim , Sidorova Natalia , Van der Aalst Wil
Published: November 2017

Planning human activities within business processes often happens based on the same methods and algorithms as are used in the area of manufacturing systems. However, human behaviour is quite different from machine behaviour. Their performance depends on a number of factors, including workload, stress, personal preferences, etc. In this article we describe an approach for scheduling activities of people that takes into account business rules and dynamic human performance in order to optimise the schedule. We formally describe the scheduling problem we address and discuss how it can be constructed from inputs in the form of business process models and performance measurements. Finally, we discuss and evaluate an implementation for our planning approach to show the impact of considering dynamic human performance in scheduling.
Organizational Learning Supported by Reference Architecture Models: Industry 4.0 Laboratory Study
Authors: Nardello Marco , Møller Charles , Gøtze John
Published: November 2017

The wave of the fourth industrial revolution (Industry 4.0) is bringing a new vision of the manufacturing industry. In manufacturing, one of the buzzwords of the moment is "Smart production". Smart production involves manufacturing equipment with many sensors that can generate and transmit large amounts of data. These data and information from manufacturing operations are however not shared in the organization. Therefore the organization is not using them to learn and improve their operations. To address this problem, the authors implemented in an Industry 4.0 laboratory an instance of an emerging technical standard specific for the manufacturing industry. Global manufacturing experts consider the Reference Architecture Model Industry 4.0 (RAMI4.0) as one of the corner stones for the implementation of Industry 4.0. The instantiation contributed to organizational learning in the laboratory by collecting and sharing up-to-date information concerning manufacturing equipment. This article discusses and generalizes the experience and outlines future research directions.
A Quality-Driven Methodology for Information Systems Integration
Authors: Zikra Iyad , Stirna Janis , Zdravkovic Jelena
Published: November 2017

Information systems integration is an essential instrument for organizations to attain advantage in today’s growing and fast changing business and technology landscapes. Integration solutions generate added value by combining the functionality and services of heterogeneous and diverse systems. Existing integration environments tend to rely heavily on technical, platform-dependent skills. Consequently, the solutions that they enable are not optimally aligned with the envisioned business goals of the organization. Furthermore, the gap between the goals and the solutions complicates the task of evaluating the quality of integration solutions. To address these challenges, we propose a quality-driven, model-driven methodology for designing and developing integration solutions. The methodology spans organizational and systems design details, providing a holistic view of the integration solution and its underlying business goals. A multi-view meta-model provides the basis for the integration design. Quality factors that affect various aspects of the integration solution guide and inform the progress of the methodology. An example business case is presented to demonstrate the application of the methodology.
Natural Model based Design in Context: an Effective Method for Environmental Problems
Authors: Kameni Eric , Van der Weide Theo , De Groot Wouter
Published: November 2017

Analyzing complex problem domains is not easy. Simulation tools support decision makers to find the best policies. Model-based system development is an approach where a model of the application domain is the central driving force when designing simulation tools. State-of-the-art techniques however still require both expert knowledge of the application domain and the implementation techniques as provided by ICT (such as multilevel agent technology). Domain experts, however, usually do not master ICT sufficiently. Modeling is more insightful for the domain expert when its goal is to formalize the language being used in that domain as a semi-natural language. At the meta level, this language describes the main concepts of the type of application domain. The model then is a concretization of this meta model. The main focus of this article is (1) to propose a natural-language-based approach to modeling application domains, (2) to show how these models can be transformed systematically into computational models, and (3) to propose the tool TiC (Tool in Context) that supports the domain expert when developing a model and generating a simulation tool. Our research methodology is based on Design Science. We verify our approach by describing the various transformation steps in detail, and by demonstrating the way of working via a sample session applying a real problem of Laf Forest Reserve deforestation in North Cameroon.
ANALYSIS OF ORE LOSSES AND DILUTION FACTORS IN BAUXITE UNDERGROUND EXPLOITATION
Authors: Majstorović Slobodan , Tošić Dražana
Published: November 2017

In this article are presented the analysis of ore losses in bauxite underground exploitation as well as the manner and possibility to increase recovery factor of ore deposit and exploitation with minimum of diluted ore with overburden. The largest losses of ore are the caracteristics of the mining process itself and the results of model studies of the ore losses and recovery for the various parameters of sublevel - transverse caving method are given in the article.
INFLUENCE OF VOLUME WEIGHT ON GABBRO UNIAXIAL COMPRESSION STRENGTH
Authors: Mandžić Kenan , Ibrahimović Adnan
Published: November 2017

Jablanica gabbro represents the highest quality architectural building stone in Bosnia and Herzegovina. Knowledge of the physical and mechanical characteristics of gabbro is an important prerequisite for the proper usage of this rock material. This paper presents a brief review of the geological characteristics Jablanica gabbro deposit, with distinct mines where exploration is performed. Paper presents the study of volume weight and uniaxial compressive strength of the standard samples, with a detailed statistical processing of the results. The obtained values of volume weight and uniaxial compressive strength are placed in correlation, in order to define the relationship between these two parameters. Correlation analysis did not produce the characteristic correlation, but pointed to the existence of dependence between these two parameters.
GEOTECHNICAL CONDITIONS FOR CREATION OF THE VERTICAL SHAFT FOR RECONSTRUCTION OF OIL PIPELINE FROM TERMINAL BROD TO CROATIAN BORDER ON SAVA RIVER
Authors: Đurić Neđo , Mitrović Petar
Published: November 2017

Reconstruction of share in an existing corridor of Terminal Brod to the Croatian border on the Sava River is part of the corridor, which continues to go across the river to Slavonski Brod. The existing corridor will be replaced on a part of Sava River, where is planned a production of a tunnel with two vertical shafts on the banks of the river. Research in the field of the shafts and tunnels are divided in two parts considering the border line between the countries Bosnia and Herzegovina and Croatia. On the right bank of the Sava River researches were conducted in the development of the vertical shaft.

The complexity of the geological structure and the proximity of of the Sava River require the development of the vertical shaft from the supporting structure of reinforced concrete (RC) midriffs. Also, the flow of water into the shaft is largely expected from its bottom, which requires manufacturing
AN EXAMPLE OF „MODERN CONSTRUCTION OF THE FACILITY“
Authors: Đurić Neđo
Published: November 2017

Today's building of facilities does not follow the study of the characteristics of the terrain on which the facility is constructed. The period of rapid construction, which can be called the "modern construction" does not follow the quality of constructed facilities. Usually it is the uncontrolled building, where is only important to build a facility without taking into account the conditions of its construction and safety during exploitation.Many steps before and during the construction of facilities are neglected, which is reflected in their safety, especially after its construction.

The paper gives an example of a negative construction of facilities, as well as an overview of what is within the geological research andstudies of the field that need to be done to adequately define the geological and geotechnical characteristics of the terrain, as the basis on which the facility is constructed. This example is just one of many negative examples today.
LOCAL PEOPLE'S ATTITUDES TOWARDS QUALITY OF ENVIRONMENT IN SERBIA – B&H CROSS-BORDER REGION
Authors: Bartula Mirjana , Radojević Uroš , Selmanagić Dragana , Zildović Erna , Nikolić Miloš
Published: November 2017

Public participation in environmental decision-making is nowadays accepted as an integral part of the sustainable development process and an important mean for improving quality, legitimacy and capacity of environmental assessment and decisions. When communities participate in the management of their resources in form of consultation or active involvement, there is a greater likelihood of success as people are more willing to obey their own regulations than those imposed upon them from outside. This paper presents results of a survey in Serbia-BiH cross border region that explored the attitudes of local people towards natural resources and environment quality, environmental priorities and efficiency of local government in solving environmental problems. Results were used as inputs for drafting “Action plan for sustainable use of cross border natural resource” contributing in this way to better acceptance and easier implementation of the plan at the community level.
BENTONITE/IRON OXIDE MAGNETIC COMPOSITES: CHARACTERIZATION AND APPLICATION AS Pb(II) ADSORBENTS
Authors: Danková Zuzana , Fedorová Erika , Bekényiová Alexandra
Published: November 2017

The natural clay bentonite (B) as adsorbent of lead cations was studied. To enhance its adsorption capacity, the coating by iron oxide particles, in two selected weight ratios: 2:1 (BM1) and 4:1(BM2), was used. The changes of the textural and surface parameters after the modification were studied by the low temperature nitrogen adsorption, XRD and SEM method, Mössbauer spectroscopy. The Pb(II) adsorption experiments were studied under the different conditions, such as pH of the model solutions, contact time and initial metal ion concentration. Higher adsorption rates of BM1 and BM2 samples were observed for lower initial metal ion concentrations.
THE ORIGIN OF MAGNESIUM IN THE GROUNDWATERS OF NORTHEASTERN BOSNIA
Authors: Srkalović Dado
Published: November 2017

The paper is based on 237 chemical analysis of groundwater, where the determination of magnesium origin in groundwatersof northeastern Bosnia were performed. The determination of magnesium origin in groundwaterswere carried through on the basis of Mandel & Shiftan classification. Based on the a distribution map of Mg2+ ions in groundwaters in northeastern Bosnia were drafted.
ENERGY SUSTAINABILITY OF RAMMED EARTH BUILDINGS
Authors: Hegediš Ivan , Karaman Golub , Čeh Arpad , Đurić Neđo , Kukaras Danijel , Vunjak Danilo
Published: November 2017

Earth construction has long tradition in our civilization with wide distribution in various ways and techniques of application. When combined with other natural materials it is the material for construction of comfortable space for people. Increased need for energy efficient houses actualizes this type of construction in modern conditions as a holistic solution for modern buildings. In addition to many uses of earth as a building material, rammed earth wall came to consideration since it allows us to observe most of the advantages and disadvantages of this type of construction. Finding solutions to remedy observed disadvantages will lead to improved construction of adobe, wattle-and-daub, unbaked bricks, etc. This paper is aimed at proving energy efficiency of rammed earth wall and it points out possible research directions into improvements while preserving existing benefits. The most important issue is preservation of cost efficiency of earth building while using other natural supplements into the soil mixture.
Transitioning to DNA genomes in an RNA world
Authors: Cojocaru Razvan , Unrau Peter J
Published: November 2017

The unexpected ability of an RNA polymerase ribozyme to copy RNA into DNA has ramifications for understanding how DNA genomes evolved.
Recalling the Past in Postcolonial Drama: From Counter-History to Sociopolitical Redress
Authors: Khawaldeh Imad M. , Bani-Khair Baker , Al-Khawaldeh Nisreen
Published: November 2017

Through examining the texts of Ama Ata Aidoo's  play Anowa (1970), Jack Davis's play Kullark (or Home)(1979), and Dennis Scott's play An Echo in the Bone (1974); this paper  shows how postcolonial drama functions as an effective means for exploring occluded pre-colonial and colonial periods through constructing alternative histories that both refract the official accounts of the colonialist history and redress or treat contemporary societal and political exclusions. To this end, the researchers argue that the counter-discursive/ counter-historical task of many historical postcolonial dramas is to reconstruct their histories in a way that confirms the essential socio-political function of such plays. In this sense, a conscious linkage is being made between contemporary post-colonial communities and their past pre-colonial and colonial histories.
Mechanisms of oat (Avena sativaL.) acclimation to phosphate deficiency
Authors: Żebrowska Ewa , Milewska Marta , Ciereszko Iwona
Published: November 2017

Background

Deficiency of available forms of phosphorus is common in most soils and causes reduction of crop plants growth and yield. Recently, model plants responses to phosphate (Pi) deficiency have been intensively studied. However, acclimation mechanisms of cereals like oat (Avena sativaL.), to low Pi stress remains not fully understood. Oat plants have been usually cultured on poor soils, with a low nutrient content, but their responses to such conditions are not well known, therefore the main goal of the study was to investigate the mechanisms that enable oat plants to grow under low Pi conditions.

Methods

Four oat cultivars (A. sativa, cv. Arab, Krezus, Rajtar and Szakal) were grown for three weeks in a nutrient media with various P sources: inorganic—KH2PO4(control), organic—phytate (PA) and with no phosphate (−P). The effects of Pi deficiency on the level of P, oat growth parameters, intensity of photosynthesis, plant productivity, root exudation ability, localization, activity and isoforms of acid phosphatases, enzymes involved in Pi mobilization, were estimated. In addition, the effect of mycorrhization on plant growth was also observed.

Results

All studied oat cultivars grown on Pi-deficient media had significantly decreased Pi content in the tissues. Pi deficiency caused inhibition of shoot growth, but generally it did not affect root elongation; root diameter was decreased, root/shoot ratios increased, whereas PA plants showed a similar growth to control. Photosynthesis rate and productivity parameters decreased under low Pi nutrition, however, sugar content generally increased. Studied oat cultivars did not respond to low Piviaincreased exudation of carboxylates from the roots, as pH changes in the growth media were not observed. Pi starvation significantly increased the activity of extracellular and intracellular acid phosphatases (APases) in comparison to the control plants. Three major APase isoforms were detected in oat tissues and the isoform pattern was similar in all studied conditions, usually with a higher level of one of the isoforms under Pi starvation. Generally no significant effects of mycorrhizal colonization on growth of oat cultivars were observed.

Discussion

We postulated that acid phosphatases played the most important role in oat cultivars acclimation to Pi deficiency, especially extracellular enzymes involved in Pi acquisition from soil organic P esters. These APases are mainly located in the epidermis of young roots, and may be released to the rhizosphere. On the other hand, intracellular APases could be involved in fast Pi remobilization from internal sources. Our study showed that oat, in contrast to other plants, can use phytates as the sole source of P. The studied oat cultivars demonstrated similar acclimation mechanisms to Pi deficiency, however, depending on stress level, they can use different pools of acid phosphatases.
Scaldiporia vandokkumi, a new pontoporiid (Mammalia, Cetacea, Odontoceti) from the Late Miocene to earliest Pliocene of the Westerschelde estuary (The Netherlands)
Authors: Post Klaas , Louwye Stephen , Lambert Olivier
Published: November 2017

Background

The family Pontoporiidae (Cetacea, Odontoceti, Inioidea) is currently represented in our oceans by just one species of diminutive dolphin (Pontoporia blainvillei,franciscana). AlthoughP. blainvilleiis limited to coastal waters of the South Atlantic along Brazil, Uruguay and Argentina, multiple Miocene and Pliocene fossils indicate the past presence of members of the family in the South Atlantic, South Paciifc and North Atlantic oceans. Our comprehension of the origin and diversity of this clade and of the relationships of its members with other inioids is hampered by the fact that part of the described fossil specimens, especially from the North Atlantic realm, are cranial fragments often associated to limited stratigraphic information.

Methods

Based on an almost complete fossil cranium of pontoporiid from the Westerschelde estuary, The Netherlands, whose preservation allows for detailed morphological observations, we describe a new genus and species. The latter is compared to other pontoporiids, as well as a few non-pontoporiid inioids. A phylogenetic analysis is performed to investigate the relationship of S. vandokkumiwith the best-known extinct and extant inioids. Palynological analysis of the sediment associated to the holotype is used to assess its geological age.

Results and discussion

The new genus and speciesScaldiporia vandokkumiis characterized among others by greatly thickened premaxillary eminences reaching the level of the antorbital notch. Palynologically dated from the late Tortonian—earliest Zanclean (7.6–5 Ma, Late Miocene—earliest Pliocene), this new pontoporiid confirms the surprising past diversity of marine inioids in the North Atlantic area. Finally the content of the pontoporiid subfamily Brachydelphininae is briefly discussed.
Analysis of the tendency of catch per unit effort in the mexican Pacific sailfish fishery
Authors: Macías-Zamora R , Vidaurri-Sotelo AL , Santana-Hernández H
Published: November 2017

Information from the logbooks of the longline fleet operating under Mexican flag from 1980 to 1990 was analyzed to determine the tendency of the catch per unit effort (CPUE) of the sailfish fishery. Multivariate analysis techniques (principal components analysis) were used to group the fishing units of this fleet. Time series methods were used to estimate the tendency of the CPUE as an abundance indicator, and this was compared to the behavior of the same index for sailfish sport fishing in Manzanillo, Colima, during this period. The results indicate that the resource is underutilized.
Biostratigraphy and paleoceanographic significance of the radiolarians from the protomouth of the Gulf of California
Authors: Molina-Cruz A
Published: November 2017

The presence of radiolarians in the diatomitic strata of subunit C of the Trinidad Formation (McCloy, 1984) in Baja California Sur, Mexico, is analyzed with a graphic-multivariate model in order to define a biostratigraphic frame and infer paleoceanographic events. Stichocorys peregrina and Didymocyrtis penultimus are the only index species present in the diatomites. Nevertheless, the total faunistic composition indicates that their deposition was principally promoted by upwelling processes which occurred approximately 8 to 5 million years ago, i.e., during the latest Miocene. As time elapsed in this stage, the California Current intensified until it was very evident in the protomouth of the Gulf of California. The age of the Trinidad Formation diatomites indicates that the Pacific Ocean invaded the gulf-mouth region before the tectonic processes (sea-floor accretion and spreading) were established, processes that have opened and outlined the present morphology of the Gulf of California; consequently, the basin which harbored said invasion can be called protomouth.
A retrospective chart review of opioid represcribing following nonfatal overdose at a Veterans Affairs hospital
Authors: Boyle Julia , Clement Cassandra , Atherton Abril , Stock Christopher
Published: November 2017

Introduction:

Opioid-related overdoses have risen despite extensive media coverage and apparent awareness of this public health crisis. Emergency department visits related to opioid use nearly tripled from 2004 to 2011. Patients with mental illness are more likely to be prescribed opioids and have higher rates of overdose. This retrospective chart review sought to determine if opioid represcribing occurred after patients were treated for a nonfatal opioid overdose (NFO) at a Veterans Affairs hospital.

Methods:

Patients who experienced an NFO between 2009 and 2013 were included and charts reviewed until January 1, 2016. Review of the electronic medical record (EMR) was performed to determine if and when opioids were again prescribed after NFO.

Results:

Fifty-six veterans met the inclusion criteria. A new opioid prescription was issued to 82% of patients within 3 months following the index NFO date. The average daily morphine equivalent dose prescribed before (122 mg) and after (120 mg) NFO did not differ. A subsequent opioid overdose event occurred in 25% of patients, and there was 1 fatal event. Only 1 patient had medication overdose on the problem list of their EMR.

Discussion:

Despite experiencing NFO, veterans continued to be prescribed opioids without significant changes in the drug or dose; some experienced repeated overdose events, possibly due to poor communication and documentation of NFO. Pharmacists can play a key role in clinical interventions and education of patients and prescribers.
Evaluation of process indicators of the prenatal and birth humanization program and stork network Avaliação dos indicadores de processo do Programa de Humanização no Pré-Natal e Nascimento e da Rede Cegonha
Authors: Maia Vivian Kecy Vieira , Lima Eliane de Fátima Almeida , Costa Leite Franciele Marabotti , Sousa Ana Inês , Primo Cândida Caniçali
Published: November 2017

Objetivo: Analisar os indicadores de processo do Programa de Humanização no Pré-natal e Nascimento (PHPN) e da Rede Cegonha a partir do sistema de informação de pré-natal. Método: Trata-se de um estudo epidemiológico descritivo, baseado em dados secundários do sistema de informação de pré-natal de um município da região sudeste do Brasil. Os indicadores da assistência pré-natal foram analisados utilizando-se os indicadores de processo do PHPN, da Rede Cegonha e do Manual Técnico da Atenção ao Pré-natal de Baixo Risco do Ministério da Saúde e, em seguida, foram avaliados em quatro níveis de qualidade, sendo classificados em adequada, inadequada e intermediária. Resultados: Verificou-se classificação da qualidade da assistência pré-natal insatisfatória para todos os níveis. Conclusão: São necessárias intervenções constantes pela gestão para melhoria da qualidade da assistência Pré-natal.
Experiencing feelings and weaknesses of care in schizophrenia: family caregivers vision Vivenciando sentimentos e fragilidades do cuidar em esquizofrenia: visão de familiares cuidadores
Authors: Lima Israel Coutinho Sampaio , De Andrade Lima Sérgio Beltrão
Published: November 2017

Objetivo: Compreender como se dá a sobrecarga do cuidar em esquizofrenia na visão de familiares cuidadores e analisar os sentimentos envolvidos no processo de cuidar. Métodos: Estudo do tipo qualitativo, descritivo, exploratório. Realizado no CAPS II em Teresina, Piauí, com nove familiares cuidadores, no mês de abril de 2011. Foi utilizado um roteiro de entrevistas semi-estruturado, os depoimentos foram gravados e transcritos na integra e analisados conforme Bardin. Com parecer favorável por meio do protocolo CAAE 0489.0.043.000-10 do CEP da UNINOVAFAPI. Resultados e Discussão: A categoria “Dos sentimentos as fragilidades que envolve a sobrecarga do cuidar em esquizofrenia”, demonstrou haver solidão, angustia e medo em decorrência da responsabilização do cuidar ser atribuída a um familiar exclusivo. Conclusão: Os profissionais poderão planejar melhor sua prática terapêutica, dando relevância para a vivência do cuidador, levando em considerações os sentimentos e as fragilidades que envolvem a sobrecarga do cuidado.
Quality of life and chronic renal failure Qualidade de vida e insuficiência renal crônica
Authors: Weykamp Juliana marques , Nunes Márcia Helena Baltassare , Cecagno Diana , De siqueira Hedi crecencia heckler
Published: November 2017

Objetivo: Conhecer a produção cientifica, no período de 2009 a2015, a respeito da qualidade de vida do portador de insuficiência renal crônica. Método: Revisão integrativa  realizada via online na Biblioteca Virtual em Saúde na base de dados da Literatura Latino-Americana e do Caribe em Ciências da Saúde, respeitando os  aspectos éticos em relação as autorias dos artigos. A amostra constituiu-se de 14 artigos científicos completos. Resultados e discussão: Apesar da Insuficiência Renal Crônica estar adquirindo importância no rol das doenças crônicas existe um número reduzido de artigos relacionados à temática, dentre estes, o destaque é para usuários em hemodiálise e, independente da abordagem, os estudos analisados evidenciam que várias dimensões do portador com insuficiência renal crônica são afetadas e essas influenciam na sua qualidade de vida. Conclusão: Recomenda-se novos estudos a respeito da qualidade de vida dos usuários em modalidades de tratamento como a diálise peritoneal e transplante renal.
Interrelationship of health education actions in the context of the family health strategy: nurses’ perceptions Inter-relação das ações de educação em saúde no contexto da Estratégia Saúde da Família: percepções do enfermeiro
Authors: De Sousa Vieira Francilene , Cardoso Portela Nytale Lindsay , Costa de Sousa Gleciane , Dos Santos Costa Ederson , Pinheiro Oliveira Deboráh Éllen , Lopes Mousinho Neiva Maria de Jesus
Published: November 2017

Objetivo: Conhecer as percepções do enfermeiro acerca da inter-relação das ações de educação em saúde no contexto da estratégia saúde da família. Método: Estudo de cunho qualitativo numa abordagem descritivo-exploratório com 15 enfermeiros da zona urbana de um município maranhense. O projeto foi aprovado pelo comitê de ética em pesquisa da Universidade Estadual do Maranhão através do parecer Nº 974.947. Resultados: Foram divididos em categorias: atividades educativas desenvolvidas na estratégia saúde da família; repercussão das ações sobre a comunidade; dificuldades e estratégias inerentes as ações educativas; autoavaliação do enfermeiro enquanto educador em saúde. Conclusão: A ação educativa se constitui em atividade inerente ao trabalho do enfermeiro, cujas ações estão inter-relacionadas em torno de um objetivo comum, a promoção da saúde da população. Descritores: Educação em Saúde, Estratégia Saúde da Família, Enfermeiras e Enfermeiros.
Hepatitis C and associated risks in prisons: an integrative review Hepatite C e riscos associados em presídios: uma revisão integrativa
Authors: Araújo Telma Maria Evangelista de , Pinheiro Daniella Mendes , Souza Antonio Tiago da Silva
Published: November 2017

O presente estudo teve como objetivo conhecer a produção científica atual sobre a prevalência de hepatite C e riscos associados nos presídios e publicados na literatura científica. Trata-se de uma revisão integrativa realizada nas bases de dados Web of Science, CINAHL e Lilacs, incluindo artigos nacionais e internacionais publicados entre 2009 a 2014. A partir dos critérios de inclusão e exclusão, foram selecionados 16 artigos. Predominaram os artigos descritivos (37,5%), transversais (50%). Todos apresentaram nível IV de evidência científica. A prevalência de Hepatite C foi variada e os principais fatores de risco associados à positividade para hepatite C foram o uso de drogas injetáveis, presença de tatuagem, idade. Por ser uma doença de longo curso assintomático, a hepatite C revela-se como um problema relevante no sistema prisional, exigindo mais atenção no sentido de produzir conhecimentos que orientem a adoção de medidas efetivas de controle e prevenção.
mPOS is a novel mitochondrial trigger of cell death – implications for neurodegeneration
Authors: Coyne Liam P. , Chen Xin Jie
Published: November 2017

In addition to its central role in energy metabolism, the mitochondrion has many other functions essential for cell survival. When stressed, the multifunctional mitochondria are expected to engender multifaceted cell stress with complex physiological consequences. Potential extra‐mitochondrial proteostatic burdens imposed by inefficient protein import have been largely overlooked. Accumulating evidence suggests that a diverse range of pathogenic mitochondrial stressors, which do not directly target the core protein import machinery, can reduce cell fitness by disrupting the proteostatic network in the cytosol. The resulting stress, named mitochondrial precursor overaccumulation stress (mPOS), is characterized by the toxic accumulation of unimported mitochondrial proteins in the cytosol. Here, we review our current understanding of how mitochondrial dysfunction can impact the cytosolic proteome and proteostatic signaling. We also discuss the intriguing possibility that the mPOS model may help untangle the cause–effect relationship between mitochondrial dysfunction and cytosolic protein aggregation, which are probably the two most prominent molecular hallmarks of neurodegenerative disease.
Significance of Northeast‐Trending Features in Canada Basin, Arctic Ocean
Authors: Hutchinson D. R. , Jackson H. R. , Houseknecht D. W. , Li Q. , Shimeld J. W. , Mosher D. C. , Chian D. , Saltus R. W. , Oakey G. N.
Published: November 2017

Synthesis of seismic velocity, potential field, and geological data from Canada Basin and its surrounding continental margins suggests that a northeast‐trending structural fabric has influenced the origin, evolution, and current tectonics of the basin. This structural fabric has a crustal origin, based on the persistence of these trends in upward continuation of total magnetic intensity data and vertical derivative analysis of free‐air gravity data. Three subparallel northeast‐trending features are described. Northwind Escarpment, bounding the east side of the Chukchi Borderland, extends ∼600 km and separates continental crust of Northwind Ridge from high‐velocity transitional crust in Canada Basin. A second, shorter northeast‐trending zone extends ∼300 km in northern Canada Basin and separates inferred continental crust of Sever Spur from magmatically intruded crust of the High Arctic Large Igneous Province. A third northeast‐trending feature, here called the Alaska‐Prince Patrick magnetic lineament (APPL) is inferred from magnetic data and its larger regional geologic setting. Analysis of these three features suggests strike slip or transtensional deformation played a role in the opening of Canada Basin. These features can be explained by initial Jurassic‐Early Cretaceous strike slip deformation (phase 1) followed in the Early Cretaceous (∼134 to ∼124 Ma) by rotation of Arctic Alaska with seafloor spreading orthogonal to the fossil spreading axis preserved in the central Canada Basin (phase 2). In this model, the Chukchi Borderland is part of Arctic Alaska.
Influence of Exsolved Volatiles on Reheating Silicic Magmas by Recharge and Consequences for Eruptive Style at Volcán Quizapu (Chile)
Authors: Degruyter W. , Huber C. , Bachmann O. , Cooper K. M. , Kent A. J. R.
Published: November 2017

The two most recent eruptions of Volcán Quizapu (southern Andes, Chile), only 85 years apart, were both triggered by magma recharge and extruded the same volume (about 5 km3) of the same volatile‐rich dacitic magma, but showed a remarkable shift from effusive (1846–1847) to explosive (1932) behavior. We demonstrate, using a newly developed model, that the presence or absence of an exsolved volatile phase in the reservoir strongly influences its mechanical and thermal response to new inputs of magma. We propose that, prior to the 1846–1847 effusive eruption, gas bubbles damped the build‐up of excess pressure and allowed recharge of a significant volume of magma before triggering the 1846–1847 eruption. The strong temperature increase that resulted enhanced syneruptive outgassing leading to an effusive eruption. In contrast, during the repose period between the 1847 and 1932 eruptions, new recharges found a much less compressible host reservoir as the exsolved gas phase was largely removed in response to the prior eruption, yielding rapid pressurization, minor reheating, and comparatively less syneruptive outgassing. The combination of these effects culminated in an explosive eruption.
The Geologic Exploration of the Bagnold Dune Field at Gale Crater by the Curiosity Rover
Authors: Chojnacki Matthew , Fenton Lori K.
Published: November 2017

The Mars Science Laboratory rover Curiosity engaged in a monthlong campaign investigating the Bagnold dune field in Gale crater. What represents the first in situ investigation of a dune field on another planet has resulted in a number of discoveries. Collectively, the Curiosity rover team has compiled the most comprehensive survey of any extraterrestrial aeolian system visited to date with results that yield important insights into a number of processes, including sediment transport, bed form morphology and structure, chemical and physical composition of aeolian sand, and wind regime characteristics. These findings and more are provided in detail by the JGR‐Planets Special Issue Curiosity's Bagnold Dunes Campaign, Phase I.
Photoredox Catalysis in C–S Bond Construction: Recent Progress in Photo‐Catalyzed Formation of Sulfones and Sulfoxides
Authors: Zhu Jie , Yang Wen‐Chao , Wang Xiao‐dong , Wu Lei
Published: November 2017

The emergence of radical chemistry as well as green chemistry in organic synthesis has initiated an interest in photochemistry over the past decade. With catalytic amounts of photoredox catalysts under light irradiation, high active radical species are produced, which could trigger the subsequent organic transformations smoothly. Among the various photoredox reactions, photo‐catalytic C–S bond formation continues to thrive, as the C–S bond is indispensable in many important biological and pharmaceutical compounds. Great attention has been devoted to this area as illustrated by the series of papers on sulfone and sulfoxide skeleton synthesis under irradiation published in the past years. This review summarizing the recent advances in photo‐catalyzed sulfones and sulfoxide formation is arranged by reaction type together with the sulfur source covering sulfonylation and sulfinylation reactions. It is intended to provide readers with a comprehensive understanding of photo‐catalytic C‐S bond formation and offer help for future research.

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Demographics and patient characteristics of 1209 patients with Gaucher disease: Descriptive analysis from the Gaucher Outcome Survey (GOS)
Authors: Zimran Ari , Belmatoug Nadia , Bembi Bruno , Deegan Patrick , Elstein Deborah , Fernandez‐Sasso Diego , Giraldo Pilar , Goker‐Alpan Ozlem , Lau Heather , Lukina Elena , Panahloo Zoya , Schwartz Ida Vanessa D. ,   on behalf of the GOS Study group
Published: November 2017

The Gaucher Outcome Survey (GOS) is an international Gaucher disease (GD) registry established in 2010 for patients with a confirmed GD diagnosis, regardless of GD type or treatment status, designed to evaluate the safety and long‐term effectiveness of velaglucerase alfa and other GD‐related treatments. As of February 25, 2017, 1209 patients had enrolled, the majority from Israel (44.3%) and the US (31.4%). Median age at GOS entry was 40.4 years, 44.1% were male, and 13.3% had undergone a total splenectomy. Most patients had type 1 GD (91.5%) and were of Ashkenazi Jewish ethnicity (55.8%). N370S/N370S was the most prevalent genotype, accounting for 44.2% of genotype‐confirmed individuals (n = 847); however, there was considerable variation between countries. A total of 887 (73.4%) patients had received ≥1 GD‐specific treatment at any time, most commonly imiglucerase (n = 587), velaglucerase alfa (n = 507), and alglucerase (n = 102). Hematological and visceral findings at the time of GOS entry were close to normal for most patients, probably a result of previous treatment; however, spleen volume of patients in Israel was almost double that of patients elsewhere (7.2 multiples of normal [MN] vs. 2.7, 2.9 and 4.9 MN in the US, UK and rest of world), which may be explained by a greater disease severity in this cohort. This analysis aimed to provide an overview of GOS and present baseline demographic and disease characteristics of participating patients to help improve the understanding of the natural history of GD and inform the overall management of patients with the disease.
Mutations of the integrin αIIb/β3 intracytoplasmic salt bridge cause macrothrombocytopenia and enlarged platelet α‐granules
Authors: Favier Marie , Bordet Jean‐Claude , Favier Remi , Gkalea Vasiliki , Pillois Xavier , Rameau Philippe , Debili Najet , Alessi Marie‐Christine , Nurden Paquita , Raslova Hana , Nurden Alan
Published: November 2017

Rare gain‐of‐function mutations within the ITGA2B or ITGB3 genes have been recognized to cause macrothrombocytopenia (MTP). Here we report three new families with autosomal dominant (AD) MTP, two harboring the same mutation of ITGA2B, αIIbR995W, and a third family with an ITGB3 mutation, β3D723H. In silico analysis shows how the two mutated amino acids directly modify the salt bridge linking the intra‐cytoplasmic part of αIIb to β3 of the integrin αIIbβ3. For all affected patients, the bleeding syndrome and MTP was mild to moderate. Platelet aggregation tended to be reduced but not absent. Electron microscopy associated with a morphometric analysis revealed large round platelets; a feature being the presence of abnormal large α‐granules with some giant forms showing signs of fusion. Analysis of the maturation and development of megakaryocytes reveal no defect in their early maturation but abnormal proplatelet formation was observed with increased size of the tips. Interestingly, this study revealed that in addition to the classical phenotype of patients with αIIbβ3 intracytoplasmic mutations there is an abnormal maturation of α‐granules. It is now necessary to determine if this feature is a characteristic of all mutations disturbing the αIIb R995/β3 D723 salt bridge.