bluuebunny/crossref_metadata_2025 huggingface dataset:
Prinsip Sistemik Lembaga Perdamaian PKPU Untuk Mencapai Nilai Keadilan
Authors: Suci Ivida Dewi Amrih , Shubhan M. Hadi , Poesoko Herowati , R. Murjiyanto  , Zahir Mohd Zamre Mohd , Sudiyana
Published: June 2024

Systemic principles serve as the basic basis for thought and action processes, representing interconnected elements that contribute to the formation of a comprehensive whole. Bankruptcy law is a special and special law, regulated in Articles 222 to 294 of the Bankruptcy Law and PPU, PKPU is a legal peace institution whose operational elements include deciding judges, administrators, supervisory judges, debtors, creditors, and additional elements in the PKPU institution that are guarantors if provided. Systemically, these elements are interrelated both within their own elements and with theoretical elements, namely the Ideal elements (about meaning) and the actual elements. According to Article 287 of the Bankruptcy Law and PKPU Jo Article 282 of the Bankruptcy Law and PKPU, PKPU has a final and binding decision, but it is limited, and its decision is only related to the minutes of the meeting. The verdict still has legal consequences if violated. The author’s motivation is to analyze systemic principles in the legal framework of PKPU peace institutions with the aim of upholding the principle of justice. The analysis methodology used is the legal system theory developed by Kees Schuit, focusing on the Ideal, Operational, and Actual elements. In addition, it incorporates three basic principles outlined by Gustav Radbruch – Certainty, Benefit, and Justice. The results of this study contribute prescriptive value to the field of law, especially in bankruptcy law.
KENT KÜLTÜRÜNDE AÇIK HAVA REKLAMCILIĞI, DUVAR İLAN VE AFİŞLERİNİN ÇAĞDAŞ SANATA ETKİLERİ
Authors: Sevindik İlyas
Published: June 2024

Günümüz tüketim kültürü içerisinde insanlara ulaşmanın farklı yollarından birisi de görsel
bir iletişim aracı olan; açık hava reklamcılığı, duvar ilan ve afişleridir. İnsanları bilgilendirme
amaçlı bu iletişim araçları, insan eliyle değişimleri, doğal etki ve deformasyonlarla,
estetik ve görsel bir dil olarak çağdaş resim sanatına katkı sunmaktadır. Açık hava reklam,
duvar ilanı ve afişlerin kent kültürü içerisinde sanatsal olguya dönüşümünde sanatçılar,
yaşamış oldukları dönem özelliklerine de vurgu yaparak, kendilerinden sonraki sanatçılarda
toplumsal farkındalık oluşturmayı amaçlamışlardır. Sanatçılar, plastik ve estetik
deneyimlerin ötesinde, gündelik yaşamın görsel imajları olan bu unsurları, kent kültürü
içerisinde atık malzeme vurgusu ile ele almışlardır. Yine sanatçıların farklı bir bakış açısıyla
çevre bilinci, ele aldıkları dönemin kültür, sanat, siyaset, ekonomi, tüketim çılgınlığı ve
toplumsal farkındalık gibi konulara göndermeler yapmaları araştırmayı önemli kılmaktadır.
Bu çalışmada özellikle kent kültürüne vurgu yapılarak, açık hava reklamcılığı duvar
ve ilanlarının çağdaş sanata olan etkileri nelerdir? sorusuna cevap aranmıştır. Betimsel
tarama yöntemiyle ele alınan çalışmada, elde edilen veriler doküman analizi şeklinde bir
araya getirilmiştir. Sanatçılar eserlerinde, alışılmış plastik değerler dışında, kent kültürüne
gönderme yaptıkları ve bir kent kültürü arşivi oluşturdukları sonucuna ulaşılmıştır.
EXAMPLES OF BAG DESIGN FROM WASTE LEATHER PARTS AS MATERIAL WITHIN THE SCOPE OF SUSTAINABILITY
Authors: Koparan Yasemin , Harmankaya Hatice
Published: June 2024

Problems such as ineffective use of limited natural resources, pollution of natural water
resources, global warming, pollution of soil and air necessitate the research of renewable,
sustainable and usable alternative resources and techniques. Leather is a healthy, long-lasting,
timeless material used in clothing, shoes, accessories and lifestyle products. Undesirable
environmental wastes emerge due to the fact that leather businesses have liquid, gas
and solid wastes, and the excessive use of chemicals and resources such as energy and water
while transforming rawhides into leather products. Environmental wastes have increased
the effective use of resources and the need for usable alternatives of waste materials in
industrial areas in terms of sustainability. In the study in which the qualitative research
method was used, an action research was conducted. Within the scope of the study, 8 bags
were designed and produced from waste leather pieces. During the planning stage of the
designs, the sketches of the bag forms were drawn at first. In the development of the designs,
the general forms of the bags, the sizes, types and colors of the leather pieces were taken into
consideration, and the patterns for creating the surface were studied. Colored waste Nappa
leathers sized between 1.5 mm and 2 mm were used for bags. The tessellation method, one
of the zero-waste design techniques, was used to obtain products from leather pieces in the
study. The study aimed to contribute to both the environmental and economic aspects of
sustainability with bag designs made with waste leather.
ART IN PARTNERSHIP WITH HUMAN AND ARTIFICIAL INTELLIGENCE: CREATIVITY AND ALGORITHM
Authors: Öztürk Özgül , Balaban Yüksel
Published: June 2024

Art has been the most creative form of humans’ self-expression since time immemorial and
has taken many different forms over the years. Furthermore, digitalization in all aspects of
life has foreshadowed radical changes in art in accordance with the opportunities provided
by technology. In this study, the possibility of transferring all the characteristics of an artist
defining his art to artificial intelligence (AI) has been discussed, and whether the re-evaluation
of art production with the developments in AI and the artist’s being alive for the
continuity of his art are essential or not has been examined. With the distinguished group
study carried out in this scope, it has been aimed to explore beyond traditional approaches,
putting people at the centre of the creative process, and has greatly benefited from the expertise
of three contemporary artists working at the meeting point of art and AI in Istanbul,
Turkey. In this context, the in-depth interview method as a qualitative research method
has been conducted in the study, the opinions of the interviewed artists on the topic have
been evaluated, and the related questions of the arguments have been analysed. All things
considered, two conclusions have been drawn: an artist’s work or a particular section of an
art movement might be reproduced using possibilities created by digital art, and given the
current opportunities and conditions of this age, AI systems are unlikely to replace artists
and generate art instead of them.
GELENEKSEL TÜRK KADIN GİYSİLERİNDE SIFIR ATIK TASARIM YAKLAŞIMI
Authors: Aktaş Ceren , Özkavruk Adanır Elvan
Published: June 2024

Türklere ait geleneksel giysilerin kökeni Avrasya’da yaşamış atalarının kıyafet kültürüne
uzanmaktadır. Türkler yaşadıkları iklime, coğrafyaya ve kültürlerine uyumlu, çok katlı,
dikişli ve hareket serbestliği sağlayan giysiler giymişler, dar enli dokunan kumaşlardan verimi
en çok sağlayan kalıp yöntemlerini kullanmışlardır. Türk geleneksel giysilerinin kesim
özellikleri kumaşı ekonomik kullanmak ve fire oluşturmamak üzerine temellenmiş, günlük
hayatta ve özel günlerde kullanılan, belli bir sırada üst üste giyilen giysilerde bu yöntem
uygulanmıştır. Günümüzde kumaş atıkları büyük bir sorun haline geldiğinden sıfır atık
ve sürdürülebilir moda kavramlarıyla çözümler üretilmeye çalışılmaktadır. Bu anlayışın
yeni bir olgu olduğu düşünülse de tarihi giysiler incelendiğinde sıfır atık tasarım yaklaşımının
yüzyıllar öncesinden uygulandığı söylenebilir. Bu çalışmada, Osmanlı İmparatorluğu
döneminde 19. yüzyıl ve 20. yüzyıla tarihlenen geleneksel kadın giysilerinde kalıp ve
kesim açısından sıfır atık tasarım yaklaşımının uygulanışı ele alınmıştır. İzmir Etnografya
Müzesi’nde bulunan üç etek, cepken ve şalvardan oluşan toplam otuz sekiz adet giysi incelenmiştir.
Sonuçlar geleneksel Türk giysilerinde sıfır atık kalıp ve kesim yöntemlerinin
kullanıldığını bu sayede fire oranının önemli ölçüde azaldığını göstermektedir. Geleneksel
giysilere ait üretim süreçlerinin derinlemesine incelendiği bu çalışmayla gelecekte sıfır atık
yöntemi ile yapılacak tasarımlara kaynak oluşturması hedeflenmiştir.
Faster, higher, stronger: the evolution of clinical perspectives on pan-TB
Authors: Fu Liang , Deng Guofang , Lu Hongzhou
Published: June 2024

The landscape of tuberculosis (TB) treatment is evolving rapidly, especially in the face of drug-resistant strains. This review explores the historical and contemporary developments in drug-susceptible TB (DS-TB) and multidrug-resistant TB (MDR-TB) therapies, with a focus on the emerging role of pan-TB strategies. Using a non-systematic literature review method, we analyzed peer-reviewed articles, clinical trial reports, and studies on DS-TB, MDR-TB, and pan-TB approaches published from January 2000 to December 2023. Our findings highlight significant advancements in TB therapies, including the WHO-endorsed four-month regimen for DS-TB and the all-oral BPaL/M regimen for MDR-TB. Pan-TB initiatives, such as the BPMZ regimen by TB Alliance and the Project to Accelerate New Treatments for Tuberculosis (PAN-TB), aim to develop universal regimens for both DS-TB and MDR-TB, showing promise in enhancing treatment efficacy and patient adherence. Continuous innovation and adaptable strategies are crucial in the fight against TB. Pan-TB approaches have the potential to effectively address both DS-TB and MDR-TB, and recent advancements underscore their importance. Future research should focus on extensive clinical trials to validate these strategies and explore innovative methods to improve treatment adherence and efficacy. This review provides valuable insights for clinicians and researchers, emphasizing the importance of developing and implementing effective, universally applicable pan-TB treatments, which are critical for improving patient outcomes and advancing global TB control efforts.
Longitudinal biomarker evaluation in Fabry disease patients receiving lentivirus-mediated gene therapy
Authors: Auray-Blais Christiane , Lavoie Pamela , Martineau Tristan , Rupar C. Anthony , Barber Dwayne L. , Keating Armand , Foley Ronan , Khan Aneal , West Michael L. , Medin Jeffrey A.
Published: June 2024

Aim: In 2016, a team of Canadian researchers initiated the world’s first gene therapy clinical trial for Fabry disease. The study, aiming to determine the safety and toxicity of lentivirus α-galactosidase A transduced autologous CD34+ cells in adult males with Fabry disease (n = 5), was conducted at three Canadian centers. The objective of the present work was to evaluate a profile of Fabry disease-related biomarkers in five participants during a 5-year surveillance period, as part of the evaluation of this novel therapy.

Methods: Sixteen globotriaosylceramide (Gb3) isoforms and eight globotriaosylsphingosine (lyso-Gb3) analogues were measured by LC-MS/MS in plasma and urine at numerous time points before and after gene therapy. Plasma and peripheral blood leukocyte α-galactosidase A activity were also measured.

Results: Levels of urine and plasma lyso-Gb3 and analogues, and urine Gb3 were lower after gene therapy and while treated with enzyme replacement therapy (ERT) compared to baseline (before gene therapy) in participants treated with ERT only. Three participants chose to cease ERT treatment at some point after gene therapy. Two of these patients had lower levels of urine and plasma lyso-Gb3 and analogues compared to baseline, whereas one participant had higher levels of these biomarkers compared to baseline. An increase in urine Gb3 was observed when ERT treatment ceased after gene therapy (P < 0.05) in all three participants.

Conclusion: The evaluation of this complete glycosphingolipid biomarker profile was useful in monitoring the biochemical response to gene therapy in this cohort of five patients with Fabry disease.
ABİDİN PAŞA’DA TERAKKİ VE SAADET TASAVVURU
Authors: İbanoğlu Fulya
Published: June 2024

Türkçede umumiyetle “fertlerin ve cemiyetlerin manevi yükselişleri” manasında kullanılan terakki 18. yüzyıl sonrasında çizgisel ilerleme manasındaki progress kelimesiyle benzer manalar kazanmıştır. İlerleyen toplumların daha mutlu olduğu inancı kelimenin muhtevasına dahil olmuştur. Bu durum terakki kelimesinin Türkçede iki farklı manaya işaret etmesiyle neticelenmiştir: Maddi ve manevi terakki.

Terakki kelimesinin farklı devirlerde, meşrep ve meslek bakımından farklı isimlerin metinlerinde kullanımı, kadim literatürdeki manalarıyla benzerliklerinin, ayrıldıkları noktaların tespiti hem daha iyi anlaşılmasına hem de bunu metinlerinde kullanan isimlerin entellektüel biyografilerine katkı sağlayacaktır. Nitekim sufi meşrep bir bürokrat olan Abidin Paşa’nın Devr-i Hamidî’de tefsir ve ahlak sahasında yazdığı eserlerinde terakki kelimesini kullanımı, saadet deyince ne anladığı dikkate değer bir örnektir.

Bu çalışmada, Abidin Paşa’nın maddi terakkiyi teknik-teknoloji, manevi terakkiyi İslam’ın hakkıyla tatbik edilmesi neticesinde görülen ahlaki terakki olarak tasavvur etmesine dikkat çekilmiş; terakki kelimesine yüklediği manalar ve saadetle kurduğu irtibat tespit ve tahlil edilmiştir.
Perlindungan Hukum Bagi Konsumen Perumahan Atas Tidak Terpenuhinya Standar Mutu Bangunan Berdasarkan Undang-Undang Nomor 8 Tahun 1999 Tentang Perlindungan Konsumen (Studi Putusan Nomor 7/Pdt.Sus-Bpsk/2020/PN Lht)
Authors: Azizah Lia , Suyadi Suyadi , Hastuti Wiwik Yuni
Published: June 2024

Konsumen berpeluang besar mengalami kerugian dalam jual beli sehingga harus ada jaminan hukum perlindungan konsumen. Jual beli rumah antara Pelaku Usaha dengan Konsumen berpotensi menimbulkan kerugian Konsumen akibat standar mutu pembangunan yang tidak dipenuhi Pelaku Usaha. Konsumen berhak mendapat ganti rugi jika kerugiannya akibat kesalahan Pelaku Usaha. Tujuan penelitian ini adalah untuk mengetahui bagaimana Perlindungan Hukum terhadap Konsumen Perumahan dalam Putusan Nomor 7/Pdt.Sus-BPSK/2020/PN Lht berdasarkan Undang-Undang Nomor 8 Tahun 1999 Tentang Perlindungan Konsumen.Penelitian ini menggunakan pendekatan yuridis normatif dengan spesifikasi penelitian deskriptif analitis. Sumber data yang digunakan merupakan data sekunder, terdiri dari bahan hukum primer, sekunder, dan tersier yang dikumpulkan melalui studi kepustakaan. Data tersebut kemudian diolah serta dianalisis menggunakan metode normatif kualitatif dan disajikan dalam bentuk teks naratif.Berdasarkan hasil penelitian dan pembahasan, dapat disimpulkan bahwa PT Lahat Maju Jaya selaku Pelaku Usaha melanggar kewajiban Pelaku Usaha Pasal 7 huruf d dan f, Pasal 8 ayat (1), serta Pasal 25 ayat (1) UUPK, sehingga dapat dikenai sanksi pidana berdasarkan Pasal 62 ayat (1) UUPK, dan sanksi administratif berdasarkan Pasal 60 UUPK. Berdasarkan Pasal 4 huruf h, Pasal 7 huruf f dan Pasal 19 UUPK, PT Lahat Maju Jaya wajib bertanggungjawab memberikan ganti rugi kepada Konsumen. Namun, Ira Agustriana selaku Konsumen belum mendapatkan haknya atas ganti rugi sebab Putusan BPSK Kota Lubuklinggau yang telah mengabulkan gugatan Konsumen dinyatakan batal demi hukum oleh Majelis Hakim Pengadilan Negeri Lahat, akibat tidak berwenang memeriksa, mengadili, dan memutus perkara berdasarkan Pasal 17 huruf b Keputusan Menteri Perindustrian dan Perdagangan Nomor 25 Tahun 2011.
Immune system effectors as biomarkers of prognosis after acute burns in a case-control study
Authors: Ferrari Alejandro , Croce Lorena Di , Saavedra Sabrina , Hartwig Marisel , Perrone Omar , Guzmán María Alejandra
Published: June 2024

Burns are a global health problem due to frequent complications, which lead to systemic inflammation, acute respiratory distress syndrome, multiorgan dysfunction, and death. Following the initial injury, it has been demonstrated that the immune system plays a key role in early inflammation, tissue regeneration, and the response against pathogens. In this study, the performance of laboratory determinations as biomarkers of prognosis in acute burned patients was evaluated in a retrospective case-control protocol. Laboratory determinations were immunoglobulin G (IgG), immunoglobulin M (IgM), C-reactive protein (CRP), complement C4 protein (C4), total serum protein (TP), albumin, prealbumin, cholesterol (CHOL), pseudocholinesterase activity (CHE), and transferrin. Patients in the deceased group (DG) showed lower initial IgG levels (p < 0.05) than patients in the survivor group (SG), with a negative predictive value (NPV) of 0.86, and this difference persisted during the hospitalization period. Furthermore, DG patients showed a decrease in CHOL and CHE during the hospitalization period (NPV of 0.86), a tendency that was not observed for the SG. Albumin, TP, C4, and transferrin showed lower initial values in DG than the SG, with a strong correlation with the total burned surface area (TBSA). These results indicate that IgG, CHOL, and CHE measurement might provide useful information for medical intervention independently of the TBSA and suggest that the measurement of TBSA-linked parameters might help to estimate the severity of burns more objectively. In this paper, the causes and implications of the alteration of effector molecules of the immune system are discussed.
Exploring the role of HPV - from Sexually Transmitted Infection to Oropharyngeal Carcinoma
Authors: Srinivasan Rajsri Kritika , Rao Vaishnavi , Vardhman Sonaj
Published: June 2024

Human papillomavirus (HPV), a DNA virus, causes one the most common sexually transmitted infections (STI), spreading through direct sexual contact to the anogenital and oropharyngeal regions. Although most infected individuals may be asymptomatic and naturally undergo viral clearance, in some individuals HPV causes carcinogenesis of the infected epithelia. HPV now accounts for over 70% of oropharyngeal carcinomas (OPC). More than 90% of these OPC are associated with HPV 16, one of the 14 high-risk subtypes. In recent years, HPV positive (HPV+) OPC has been one of the most rapidly rising cancers, by new cancer incidence rates, especially among men. The HPV driven OPCs present some unique infection driven cellular and molecular features, constituting distinct preventive, therapeutic and prognostic strategies, in contrast to HPV negative (HPV-) OPC. In this manuscript, we drive through the role of HPV, from a sexually transmitted infection to malignancy transformation landscape, while parsing through the significant immune response environment. In this comprehensive review we collate key literature around transmission and epidemiology of HPV, while addressing the current state of clinical management, diagnosis, prevention and screening strategies, that can help shed light on this critical area.
Strategic Dimensions of Eco-Innovation Adoption in Manufacturing SMEs in the Context of Mexico City
Authors: Barragán-Hernández Andrés David , Aguilar-Fernández Mario
Published: June 2024

This paper investigates the strategic dimensions influencing the adoption of environmental inno-vations (EIs) in small and medium-sized manufacturing enterprises (SMEs) in Mexico City. The study aims to understand the fundamental strategic dimensions defining eco-innovation and ex-amine how SMEs manage the complexities of incorporating these practices. Employing a mixed methods approach with documentary analysis and expert interviews; the study identifies key factors influencing EI adoption through causal maps and the Viable System Model. Findings high-light the significance of external and internal factors such as competitive pressure, economic con-straints, technological capabilities, political support, and social influence. This integrative approach emphasizes the importance of adaptability and responsiveness, presenting eco-innovation as a source of sustainable competitive advantage for SMEs.
Advancing Sustainable Healthcare Technology Management: Developing a Comprehensive Risk Assessment Framework with Fuzzy AHP, Integrating External and Internal Factors in the Gulf Region
Authors: Mahmoud Tasneem , Balachandran Wamadeva , Altayyar Saleh
Published: June 2024

In the context of healthcare technology management (HTM) in Saudi Arabia and the Gulf region, this study addresses a significant gap by exploring both external and internal risk factors affecting HTM performance. Previous research has primarily focused on modeling or predicting failures in medical devices, mostly examining internal (endogenous) factors that impact device performance and the development of optimal service strategies. However, a comprehensive investigation of external (exogenous) factors has been notably absent. This research introduces a novel hierarchical risk management framework, designed to accommodate the broad array of healthcare technologies, not limited to medical devices. It significantly advances the field by thoroughly investigating and validating a comprehensive set of 53 risk factors and assessing their influence on HTM. Additionally, this study embraces the perspective of enterprise risk management (ERM) and expands it to identify and incorporate a wider range of risk factors, offering a more holistic and strategic approach to risk assessment in healthcare technology management. The findings reveal that several external and internal factors previously underexplored significantly impact HTM performance. Notably, the Fuzzy AHP survey identified “design risk” under facility and environmental risks as the highest risk for HTM in the region. Furthermore, the study reveals that three out of the top ten risks are related to “facility and internal environmental” factors, six are related to technological endogenous factors, and only one is related to managerial factors. This distribution underscores the critical areas for intervention and the need for robust facility and technology management strategies.
In conclusion, this research not only fills a critical void by providing a robust framework for healthcare technology risk assessment but also broadens the scope of risk analysis to include a wider array of technologies, thereby enhancing the efficacy and safety of healthcare interventions in the region. Additionally, the proposed hierarchy provides insights into the underlying risk factors for healthcare technology management, with potential applications extending beyond the regional context to a global scale. Moreover, the equation we propose offers a novel perspective on the key risk factors involved in healthcare technology management, presenting insights with far-reaching implications applicable not only regionally but also on a global level. This framework also supports sustainability goals by encouraging the efficient and responsible utilization and management of healthcare technologies, essential for ensuring the long-term economic and environmental sustainability of medical technology use.
Unignorable Factors in Carbon Stocks Assessment of Tropical Forests: Buttress Roots
Authors: Wang Xu , Li Zhaojia , Mwangi Brian , Zhao Houben , Qiu Zhijun , Zhou Guangyi , Yang Mengmeng , Wu Zhongmin , Li Yuelin
Published: June 2024

Assessing carbon stocks in tropical forests is crucial for understanding their role in mitigating climate change. (1) Background: However, existing assessments have underestimated certain factors that can substantially influence carbon dynamics. (2) Methods: This study focuses on one such factor - buttress roots from a tropical forest. (3) Results: Our findings reveal that a significant proportion of trees (69.57%) had 3 to 5 buttress roots per tree. The total biomass of the buttress roots and the aboveground portion of the trees with buttress roots were calculated to be 8.5 tonnes/ha and 10.7 tonnes/ha respectively. The buttress root biomass accounted for 16.18% of the total tree biomass. It was observed that the presence of buttress roots during both the rainy and dry seasons increased the soil organic carbon content by an average of 20.8% in the upslope areas with buttress roots. During the rainy season, the presence of buttress roots did not affect the heavy fraction organic carbon in the soil layers in a statistically significant way. Regardless of the season, the soil respiration rate in the areas without buttress roots was higher than that in the areas with buttress roots. The presence of buttress roots had a positive effect on soil nutrient concentration in all seasons, creating a healthier environment for trees. Tree species with buttress roots had on average 20% higher organic carbon content during both the wet and dry seasons. (4) Conclusions: These findings highlight the importance of considering buttress roots in carbon stock assessments and forest management strategies. By integrating buttress roots into carbon accounting models, we can obtain more accurate estimates of carbon stock potential and develop more effective conservation and restoration strategies for tropical forests.
Return to Work After Breast Cancer. A One-Year Mixed-Method Study
Authors: Magnavita Nicola , Meraglia Igor , Terribile Daniela Andreina
Published: June 2024

Breast cancer (BC) is the most common invasive neoplasm and affects many women of working age. The return to work (RTW) of female survivors (BCSs) is associated with a better quality of life and longer survival. A tailored intervention to promote RTW was launched in 2022. A year later, the women were contacted to find out if RTW had occurred regularly and what their health conditions were compared to baseline. BCSs reported excessive fatigue, poor sleep quality, anxiety, depression and reduced work ability; these parameters had not improved significantly compared to baseline. Thematic analysis of the interviews confirmed the presence of personal, company and societal factors that could hinder or favor RTW. The interviews demonstrated that, even in an economically developed country that has provided numerous benefits for BCSs, protection is not always effective. Personalized intervention seems necessary to complete the process of reintegrating BCSs into their future working careers.
Surgical Outcomes of Modified Intraocular Lens Suturing With Forceps-Assisted Haptics Extraction: A Clinical and Basic Evaluation
Authors: Sotani Yasuyuki , Imai Hisanori , Kishi Maya , Yamada Hiroko , Matsumiya Wataru , Miki Akiko , Kusuhara Sentaro , Nakamura Makoto
Published: June 2024

Background/Objectives: Postoperative intraocular lens (IOL) is a risk associated with IOL scleral fixation. However, the cause of IOL tilt during IOL suturing remains unclear. Therefore, this study aimed to evaluate the surgical outcomes of a modified IOL suturing technique and investigate the factors contributing to postoperative IOL tilt and decentration. Methods: We included 25 eyes of 22 patients who underwent IOL suturing between April 2018 and February 2020. A modified IOL suturing technique that decreased the need for intraocular suture manipulation was used. Factors contributing to IOL tilt and decentration were investigated using an intraoperative optical coherence tomography (iOCT) system. Results: The mean postoperative best-corrected visual acuity improved from 0.15 ± 0.45 to -0.02 ± 0.19 (p = 0.02). The mean IOL tilt angle at the last visit after surgery was 1.84 ± 1.28 degrees. The study revealed that the distance of the scleral puncture site from the corneal limbus had a stronger effect on IOL tilt; while, the suture position of the haptics had a greater effect on IOL decentration. Conclusions: The modified IOL suturing technique, which avoids intraocular suture handling, had favorable surgical outcomes with improved postoperative visual acuity and controlled IOL tilt and decentration. Accurate surgical techniques and careful measurement of distances during surgery are crucial for preventing postoperative IOL tilt and decentration.
Vascular Ring Surgical Repair: Re-implantation of the Left Subclavian Artery into the Left Carotid Artery in a Pediatric Patient.
Authors: Rodríguez Brilla María Alejandra , Kausen Kevin Daniel , Ali Aboozar T , Paudel Govinda , Bautista-Hernandez Victor
Published: June 2024

Vascular rings are a rare congenital anomaly of the aortic arch in which a ring-shaped structure forms surrounding the trachea and/or esophagus, potentially causing compression. We describe the case of a 14-month-old female patient with failure to thrive secondary to dysphagia, and a vascular ring formed by a right aortic arch, an aberrant left subclavian artery, and a left liga-mentum arteriosum. Surgical repair involved ligamentum arteriosum division, Kommerell’s di-verticulum obliteration, and left subclavian artery re-implantation into the left carotid artery. Endoscopy and EndoFLIPTM evaluated intraoperative improvement in esophageal narrowing and impedance, respectively. Postoperative period was uneventful and follow-up visits demonstrated dysphagia resolution and a patent re-implanted left subclavian artery.
Quantitative Trait Loci Mapping and Candidate Gene Analysis for Fiber Quality Traits in Upland Cotton
Authors: Jia Xiaoyun , Zhao Hongxia , Zhu Jijie , Wang Hantao , Wang Shijie , Li Miao , Wang Guoyin
Published: June 2024

Superior fiber quality is one of the most important objectives in cotton breeding. To detect the genetic basis underlying fiber quality, an F2 population containing 413 plants was constructed by crossing Jifeng 914 and Jifeng 173, both of which have superior fiber quality, with Jifeng 173 being better. Five fiber quality traits were investigated in the F2, F2:3, F2:4, and F2:5 populations. Quantitative trait loci (QTL) mapping was conducted based on a high-density genetic map containing 11,488 single nucleotide polymorphisms (SNPs) and spanning 4,202.12 cM in length. Transgressive segregation patterns and complex correlations in the five tested traits were observed. A total of 108 QTLs were found, including 27 for fiber length (FL), 16 for fiber strength (FS), 24 for micronaire (MC), 17 for fiber uniformity (FU), and 24 for fiber elongation rate (FE). Chromosome A7 contained 12 QTL, ranking the first. No QTL was found on chromosome D1 and D11. Each QTL contributed 1.98%–21.45% to the phenotypic variation (PV), including 13 major effect QTLs that contributed more than 10% toward PV. Two QTLs could be repeatedly detected in three populations, including qFL-D3-2 in F2, F2:4, and F2:5 with 9.18%–21.45% of PV, qFS-A11-1 in F2:3, F2:4 and F2:5 with 6.05%–10.41% of PV. Another seven stable QTLs could be detected in two populations, including four major effect QTLs: qFL-A12-3, qFS-D10-2, qMC-D6-2, and qMC-D8-1. Fourteen QTL-overlapping regions were found, which might explain the complex correlations among the five phenotypic traits. Four regions on chromosome A11, D3, D6, and D10 covered by both stable and major effect QTLs are promising for further fine mapping. The genomic regions of the two QTLs detected in three populations and the four major effect QTLs contain 810 genes. Gene functional analysis revealed that the annotated genes are mainly involved in protein binding and metabolic pathways. Fifteen candidate genes in the qFL-D3-2 region are highly expressed in fiber or ovules during fiber initiation, elongation, secondary cell wall thickening, or maturation stages. qRT-PCR revealed that Ghir_D03G005440.1 and Ghir_D03G011310.1 may play a role in promoting fiber initiation, Ghir_D03G006470.1 may be beneficial for promoting fiber elongation. This study provides more information for revealing the molecular genetic basis underlying cotton fiber quality.
Long-Read Sequencing Unlocks New Insights into the Amphidinium carterae Microbiome
Authors: Judd Miranda , Wira Jens , Place Allen R , Bachvaroff Tsvetan
Published: June 2024

Dinoflagellates are one of the largest groups of marine microalgae and exhibit diverse trophic strategies. Within these niches, dinoflagellates can produce secondary metabolites that are known to be toxic, which can lead to ecologically harmful blooms. Amphidinium carterae is one species of dinoflagellate that produces toxic compounds and is used as a model for dinoflagellate studies. The extent to which the microbiome surrounding A. carterae affects its growth and secondary metabolite synthesis is still being assessed, as well as the impact of bacterial data on sequencing and assembly. An antibiotic cocktail was previously shown to eliminate 16S amplification from the dinoflagellate culture. Even with drastically reduced bacterial numbers, bacterial populations are likely to be present. In this experiment we used novel Nanopore long-read sequencing techniques on A. carterae cultures to assemble 15 full bacterial genomes ranging from 2.9-6.0 Mb and found that the use of antibiotics decreased the percentage of reads mapping back to bacteria. We also identified shifts in the microbiome composition and identified a potentially deleterious bacterial species arising in the absence of the antibiotic-treatment. Multiple antibiotic-resistance genes were identified, as well as evidence that the bacterial population do not contribute to toxic secondary metabolite synthesis.
Experimental and Theoretical Analysis of Rayleigh and Leaky-Sezawa Waves Propagating in ZnO/Fused Silica Substrates
Authors: Caliendo Cinzia , Benetti Massimiliano , Cannatà Domenico , Laidoudi Farouk
Published: June 2024

Piezoelectric c-axis oriented zinc oxide (ZnO) thin films, from 1.8 up to 6.6 µm thick, have been grown by radio frequency magnetron sputtering technique onto fused silica substrates. A delay line consisting in two interdigital transducers (IDTs) with wavelength λ = 80 µm was photolith-ographically implemented onto the surface of the ZnO layers. Due to the IDTs split finger con-figuration and metallization ratio (0.5), the propagation of both the fundamental, third and nineth harmonic Rayleigh waves is excited; also, three leaky surface acoustic waves (SAWs) were detected travelling at velocity close to that of the longitudinal bulk wave in SiO2. The acoustic waves propagation in ZnO/fused silica was simulated by using 2D finite-element method (FEM) tech-nique to identify the nature of the experimentally detected waves. It turned out that, in addition to the fundamental and harmonic Rayleigh waves, also high-frequency leaky surface waves are ex-cited by the harmonic wavelengths; such modes are identified as leaky-Sezawa (LS) waves under cut-off. The velocity of all the modes was found in good agreement with the theoretically calcu-lated values. The existence of a low-loss region for the Sezawa wave below the cut off was theo-retically predicted and experimentally assessed.
Animal Models of Autistic-Like Behavior: Is the Time for a Scoring System with More Accurate Definitions?
Authors: Ornoy Asher , Echefu Boniface , Becker Maria
Published: June 2024

Appropriate animal models of human diseases are a cornerstone in the advancement of science and medicine. To create animal models of neuropsychiatric and neurobehavioral diseases such as ASD necessitates the development of sufficient neurobehavioral measuring tools to translate human behavior to expected measurable behavioral features in animals. Indeed, at least in rodents, adequate neurobehavioral and neurological tests have been developed. Since ASD is characterized by a number of specific behavioral trends with significant severity, animal models of autistic-like behavior have to demonstrate the specific characteristic features, namely impaired social interactions, and communication, restricted, repetitive behavioral patterns with association to several additional impairments such as somatosensory, motor and memory impairments. Thus, an appropriate model must show behavioral impairment of a minimal number of neurobehavioral characteristics using an adequate number of behavioral tests.
The proper animal models enable the study of ASD like-behavior from the etiologic, pathogenetic and therapeutic aspects. From the etiologic aspects, models have been developed by the use of immunogenic substances like polyinosinic-polycytidylic acid (PolyIC), Lipopolysaccharide (LPS) and propionic acid or other well-documented immunogens or pathogens, like mycobacterium tuberculosis. Another approach is the use of chemicals like valproic acid, Polychlorinated biphenyls (PCBs), organophosphate pesticides - chlorpyrifos (CPF) and others. These substances were administered either prenatally, generally after the period of major organogenesis, or, especially in rodents, during the early postnatal life. In addition, using modern genetic manipulation methods, genetic models have been created of almost all human genetic diseases that are manifested by autistic like behavior (i.e. fragile X, Rett syndrome, SHANK gene mutation Neuroligin genes and others). Ideally, we should not only evaluate the different behavioral modes affected by the ASD-like behavior but also assess the severity of the behavioral deviations by an appropriate scoring system, as applied to humans.
Comparative Study for DC-DC Converter Output Bank’s Reliability Evaluation using Prediction Standards MIL-HDBK-217F vs. TelcordiaSR-332
Authors: Butnicu Dan
Published: June 2024

In the last decade, a higher level of reliability became a compulsory demand when it comes to modern DC-DC converters. This work addresses the main reliability metrics: the failure rate λλ and MTBF of an output capacitor bank used within a high current low voltage buck converter due to many studies have shown that the output capacitor bank was demonstrated being the most critical component within the converter. Many authors treated this issue, usually by doing reliability predictions. The majority of the papers use only one specific Standard Prediction to solve the problem. Herein calculation was done using both the older standard MIL-HDBK-217 and the latest one Telcordia SR-332, providing a benchmark comparison between the two which is a helpful tool for the output capacitor selection in the early stage design. Military standard was well accepted for decades in order to reliability prediction even on industrial electronics and is still used today under a critical manner because no more update after the latest version MIL-HDBK-217F - Notice 2 released in 1995. Since then, newer prediction standards had appeared in the electronics reliability market. Over time, this standard was mostly used but it does not accurately model the reliability because lack of taking account of mission profile. The above-mentioned newer standard – i.e., Telcordia SR-332 is trying to compensate also the lack of the newest component technology in the older standard (which is the first standard released on the market) supplying useful design data for design engineers who use the so-called “design with the reliability in mind” concept. Within the paper were established the environmental condition for the passive components by means of a PoL (Point of load) buck converter that is used for both calculation methods. The influence of temperature and several specific concepts like reference conditions, operating conditions, ripple, and internal self-heating were taking account in order to display the results. The temperature for the capacitor’s capsule needed in πT stress factor calculation was derived by PSPICE simulation. High fidelity and dedicated SPICE models provided by the manufacturer were used for MOSFETs, polymer electrolytic, and MLCC capacitors that compose the converter.
An Insight into Perfusion Anisotropy within Solid Murine Lung Cancer Tumors
Authors: Martino Antonio , Terracciano Rossana , Milićević Bogdan , Milosevic Miljan , Simić Vladimir , Fallon Blake C. , Carcamo-Bahena Yareli , Royal Amber Lee Rose , Carcamo-Bahena Aileen Ayme , Butler E. Brian , Willson Richard C. , Kojić Miloš , Filgueira Carly Sue
Published: June 2024

Blood vessels are essential for maintaining tumor growth, progression, and metastasis, yet the tumor vasculature is under a constant state of remodeling. Since the tumor vasculature is an attractive therapeutic target, there is a need to predict the dynamic changes in intratumoral fluid pressure and velocity which occur across the tumor microenvironment (TME). The goal of this study is to get insight into perfusion anisotropy within lung tumors. To achieve this goal, we used the perfusion marker Hoechst 33342 and vascular endothelial marker CD31 to stain tumor sections from C57BL/6 mice harboring Lewis Lung Carcinoma tumors on their flank. Vasculature, capillary diameter, and permeability distribution were extracted at different time points along the tumor growth curve. A computational model was generated applying a unique modeling approach based on the smeared physical fields (Kojic Transport Model, KTM). KTM predicts spatial and temporal changes in intratumoral pressure and fluid velocity within the growing tumor. Anisotropic perfusion occurs within two domains - capillary and extracellular space. Anisotropy in tumor structure causes nonuniform distribution of pressure and fluid velocity. These results provide insights regarding local vascular distribution for optimal drug dosing and delivery to better predict distribution and duration of retention within the TME.
Net Zero Agrivoltaic Arrays for Agrotunnel Vertical Growing Systems: Energy Analysis and System Sizing
Authors: Asgari Nima , Jamil Uzair , Pearce Joshua M.
Published: June 2024

To control the volatility and reduce the electricity costs for indoor farming, the agrivoltaics agrotunnel introduced here uses: 1) high insulation for a building dedicated to vertical growing, 2) high-efficiency LED lighting, 3) heat pumps (HPs), and 4), solar photovoltaics (PV) provide known electric costs for 25 years. In order to size the PV array, this study develops a thermal model for agrotunnel load calculations and validates it using the Hourly Analysis Program and measured data so the effect of plants’ evapotranspiration can be included. HPs are sized, plug loads (i.e., water pump energy needed to provide for the hybrid aeroponics/hydroponics system, DC power running the LEDs hung on grow walls, and dehumidifier assisting in moisture condensation in summer) are measured/modeled. Ultimately, all models are combined to establish an annual load profile for an agrotunnel that is then used to model the necessary PV to power the system throughout the year. The results find that agrivoltaics to power an agrotunnel range from 40 to 50kW and make up an areas from 3.2 to 10.48 m²/m² of an agrotunnel footprint. Net zero agrotunnels are technically viable although future work is needed to deeply explore the economics of localized vertical food growing systems.
Dynamic and Energetic Aspects of Carotenoids In-and-Around Model Lipid Membranes Revealed in Molecular Modelling
Authors: Pasenkiewicz-Gierula Marta , Hryc Jakub , Markiewicz Michal
Published: June 2024

In the introductory part of this review, the relevant results of mostly the latest experimental studies on carotenoid absorption and availability in the human body are briefly presented. The subsequent parts summarise such topics as carotenoid carriers, body transport and tissue delivery, before finally reporting on molecular-level studies of carotenoid binding by membrane receptors. The main message of the review is contained in the section describing computational investigations of carotenoid intercalation and dynamic behaviour in lipid bilayers. The relevance of these computational studies lies in showing the direct link between the microscopic behaviour of molecules and the characteristics of their macroscopic ensembles. Furthermore, studying the interactions between carotenoids and lipid bilayers, and certainly proteins, on the molecular- and atomic-level using computational methods facilitates interpretation and explanation of the macroscopic properties of these systems and, hopefully, helps to better understand the biological functions of carotenoids.
Molecular Dynamics Study on Wear Resistance of High Entropy Alloy Coatings Considering the Effect of Temperature
Authors: Zhang Xianhe , Yang Zhengrong , Deng Yong
Published: June 2024

High entropy alloys have excellent wear resistance, so they have great application prospects in the fields of wear resistance and surface protection. In this study, the wear resistance of FeNiCrCoCu high entropy alloy coating was systematically analyzed by molecular dynamics method. FeNiCrCoCu high entropy alloy was used as a coating material to adhere to the surface of Cu matrix. The friction and nano indentation simulation of this coating material were carried out by controlling the ambient temperature. The influence of temperature on its friction properties was analyzed from five aspects: lattice structure, dislocation evolution, friction coefficient, hardness and elastic modulus. The results show that with the increase of temperature, the disorder of the lattice structure increases, which leads to the increase of the tangential force and the friction coefficient in the friction process. At 300K and 600K, the ordered lattice structure of the high entropy alloy coating material is basically the same, and thus their hardness is basically the same. However, the dislocation density at 600K is significantly reduced compared with that at 300K, resulting in the increase of the elastic modulus of the material from 173GPa to 219GPa. At the temperatures of 900K and 1200k, lattice disorder take place rapidly, and dislocation density also decreases significantly, resulting in a significant decrease in the hardness and elastic modulus of the material. When the temperature reaches 900K, the wear resistance of the FeNiCrCoCu high entropy alloy coating decreases sharply. This work is of great value to the analysis of wear resistance of high entropy alloy at high temperature.
High-Throughput Sequencing Reveals New Viroid Species in Opuntia in Mexico
Authors: Ortega-Acosta Candelario , Ochoa-Martínez* Daniel L. , Rodríguez-Leyva Esteban
Published: June 2024

In the main prickly pear (Opuntia ficus-indica) producing region in the State of Mexico, fruit production (tunas) occupies the largest cultivated area with 15,800 ha, while 900 ha are cultivated for fresh consumption (“nopal” or “nopalitos”). Two composite samples consisting of prickly pear cactus cladodes (n=6) and another of nopal vegetable (n=6) showing virus-like symptoms were collected. Both sample sets were subjected to high-throughput sequencing (HTS) to identify the viruses and viroids present. The HTS results were verified using RT-PCR and Sanger sequencing. Subsequently, 86 nopal samples (nopal vegetable, prickly pear cactus, xoconostle and wild) were analyzed via RT-PCR with specific primers for the viruses and viroids previously detected via HTS. Three viruses were discovered [Opuntia virus 2 (OV2), cactus carlavirus 1 (CCV-1), and Opuntia potexvirus A (OPV-A)], along with a previously reported viroid [Opuntia viroid 1 (OPVd-1)]. Additionally, two new viroid species were identified, provisionally named Mexican opuntia viroid (genus Pospiviroid) and Opuntia viroid 2 (OVd-2). Phylogenetic analysis, pairwise identity comparison, and conserved structural elements analysis confirmed the classification of these two viroids as new species within the Pospiviroidae family. This is the first report of a pospiviroid and two apscaviroids infecting prickly pear in the world. Overall, this study enhances our understanding of the virome associated with nopal in Mexico.