bluuebunny/crossref_metadata_2025 huggingface dataset:
Voices behind the Statistics: A Systematic Literature Review of the Lived Experience of Rheumatic Heart Disease
Authors: Haynes Emma , Mitchell Alice , Enkel Stephanie , Wyber Rosemary , Bessarab Dawn
Published: February 2020

In Australia, Aboriginal children almost entirely bear the burden of acute rheumatic fever (ARF) which often leads to rheumatic heart disease (RHD), a significant marker of inequity in Indigenous and non-Indigenous health experiences. Efforts to eradicate RHD have been unsuccessful partly due to lack of attention to voices, opinions and understandings of the people behind the statistics. This systematic review presents a critical, interpretive analysis of publications that include lived experiences of RHD. The review approach was strengths-based, informed by privileging Indigenous knowledges, perspectives and experiences, and drawing on Postcolonialism and Critical Race Theory. Fifteen publications were analysed. Nine themes were organised into three domains which interact synergistically: sociological, disease specific and health service factors. A secondary sociolinguistic analysis of quotes within the publications articulated the combined impact of these factors as ‘collective trauma’. Paucity of qualitative literature and a strong biomedical focus in the dominant narratives regarding RHD limited the findings from the reviewed publications. Noteworthy omissions included: experiences of children/adolescents; evidence of Indigenous priorities and perspectives for healthcare; discussions of power; recognition of the centrality of Indigenous knowledges and strengths; and lack of critical reflection on impacts of a dominant biomedical approach to healthcare. Privileging a biomedical approach alone is to continue colonising Indigenous healthcare.
Association of Formal and Informal Social Support With Health-Related Quality of Life Among Chinese Rural Elders
Authors: Lu Shan , Wu Yupan , Mao Zongfu , Liang Xiaohui
Published: February 2020

Objectives: To explore the association of formal and informal social support with health-related quality of life (HRQOL) among Chinese rural elders and further investigate the influence of quantity and quality of social support on their HRQOL. Methods: The sample of 4189 Chinese rural elders over 60 years old was acquired from the 2015 China Health and Retirement Longitudinal Study (CHARLS). The HRQOL was evaluated by EQ-5D-3L questionnaire. The social support assessment was mainly based on the social support rating scale (SSRS), and Tobit regression analysis was used to explore the impact of social support on HRQOL. Results: The average EQ-5D index score (0 to 1) of the Chinese rural elders was 0.78 ± 0.16. Participants who were male or with better education were found to have higher scores. Those elders living alone, suffering from chronic diseases or disabled acquired lower scores. As for formal social support, higher medical or pension insurance and more social activities statistically significantly possessed higher scores. As for informal social support, higher number of offspring had a significant association with lower scores, while more contact with children and financial support from family were shown to be statistically significantly associated with higher scores after controlling for sociodemographic characteristics. The quality of social support is more important than its quantity. An interesting finding was that the EQ-5D index scores did not support the Chinese traditional belief that ‘the more children, the more blessings’. Conclusions: The EQ-5D index scores of the rural elders in China is above the median level based on the scores of EQ-5D. Social support is significantly associated with elderly peoples’ quality of life. The results would be significant for accurately improving the life quality of Chinese rural elders from the perspective of social support.
OmixLitMiner: A Bioinformatics Tool for Prioritizing Biological Leads from ‘Omics Data Using Literature Retrieval and Data Mining
Authors: Steffen Pascal , Wu Jemma , Hariharan Shubhang , Voss Hannah , Raghunath Vijay , Molloy Mark P. , Schlüter Hartmut
Published: February 2020

Proteomics and genomics discovery experiments generate increasingly large result tables, necessitating more researcher time to convert the biological data into new knowledge. Literature review is an important step in this process and can be tedious for large scale experiments. An informed and strategic decision about which biomolecule targets should be pursued for follow-up experiments thus remains a considerable challenge. To streamline and formalise this process of literature retrieval and analysis of discovery based ‘omics data and as a decision-facilitating support tool for follow-up experiments we present OmixLitMiner, a package written in the computational language R. The tool automates the retrieval of literature from PubMed based on UniProt protein identifiers, gene names and their synonyms, combined with user defined contextual keyword search (i.e., gene ontology based). The search strategy is programmed to allow either strict or more lenient literature retrieval and the outputs are assigned to three categories describing how well characterized a regulated gene or protein is. The category helps to meet a decision, regarding which gene/protein follow-up experiments may be performed for gaining new knowledge and to exclude following already known biomarkers. We demonstrate the tool’s usefulness in this retrospective study assessing three cancer proteomics and one cancer genomics publication. Using the tool, we were able to corroborate most of the decisions in these papers as well as detect additional biomolecule leads that may be valuable for future research.
Overexpression of ABCB1 Transporter Confers Resistance to mTOR Inhibitor WYE-354 in Cancer Cells
Authors: Wang Jingqiu , Yang Dong-Hua , Yang Yuqi , Wang Jing-Quan , Cai Chao-Yun , Lei Zi-Ning , Teng Qiu-Xu , Wu Zhuo-Xun , Zhao Linguo , Chen Zhe-Sheng
Published: February 2020

The overexpressing ABCB1 transporter is one of the key factors leading to multidrug resistance (MDR). Thus, many ABCB1 inhibitors have been found to be able to overcome ABCB1-mediated MDR. However, some inhibitors also work as a substrate of ABCB1, which indicates that in order to achieve an effective reversal dosage, a higher concentration is needed to overcome the pumped function of ABCB1, which may concurrently increase the toxicity. WYE-354 is an effective and specific mTOR (mammalian target of rapamycin) inhibitor, which recently has been reported to reverse ABCB1-mediated MDR. In the current study, 3-(4,5-dimethylthiazolyl)-2,5-diphenyltetrazolium bromide (MTT) assay was carried out to determine the cell viability and reversal effect of WYE-354 in parental and drug-resistant cells. Drug accumulation was performed to examine the effect of WYE-354 on the cellular accumulation of chemotherapeutic drugs. The ATPase (adenosine triphosphatase) activity of the ABCB1 transporter in the presence or absence of WYE-354 was conducted in order to determine the impact of WYE-354 on ATP hydrolysis. Western blot analysis and immunofluorescence assay were used to investigate the protein molecules related to MDR. In addition, the interaction between the WYE-354 and ABCB1 transporter was investigated via in silico analysis. We demonstrated that WYE-354 is a substrate of ABCB1, that the overexpression of the ABCB1 transporter decreases the efficacy of WYE-354, and that the resistant WYE-354 can be reversed by an ABCB1 inhibitor at a pharmacological achievable concentration. Furthermore, WYE-354 increased the intracellular accumulation of paclitaxel in the ABCB1-mediated MDR cell line, without affecting the corresponding parental cell line, which indicated that WYE-354 could compete with other chemotherapeutic drugs for the ABCB1 transporter substrate binding site. In addition, WYE-354 received a high score in the docking analysis, indicating a strong interaction between WYE-354 and the ABCB1 transporter. The results of the ATPase analysis showed that WYE-354 could stimulate ABCB1 ATPase activity. Treatment with WYE-354 did not affect the protein expression or subcellular localization of the ABCB1. This study provides evidence that WYE-354 is a substrate of the ABCB1 transporter, implicating that WYE-354 should be avoided for use in ABCB1-mediated MDR cancer.
Effect of Low Temperature on Chlorophyll Biosynthesis and Chloroplast Biogenesis of Rice Seedlings during Greening
Authors: Zhao Yuqing , Han Qiaohong , Ding Chunbang , Huang Yan , Liao Jinqiu , Chen Tao , Feng Shiling , Zhou Lijun , Zhang Zhongwei , Chen Yanger , Yuan Shu , Yuan Ming
Published: February 2020

Rice (Oryza sativa L.) frequently suffers in late spring from severe damage due to cold spells, which causes the block of chlorophyll biosynthesis during early rice seedling greening. However, the inhibitory mechanism by which this occurs is still unclear. To explore the responsive mechanism of rice seedlings to low temperatures during greening, the effects of chilling stress on chlorophyll biosynthesis and plastid development were studied in rice seedlings. Chlorophyll biosynthesis was obviously inhibited and chlorophyll accumulation declined under low temperatures during greening. The decrease in chlorophyll synthesis was due to the inhibited synthesis of δ-aminolevulinic acid (ALA) and the suppression of conversion from protochlorophyllide (Pchlide) into chlorophylls (Chls). Meanwhile, the activities of glutamate-1-semialdehyde transaminase (GSA-AT), Mg-chelatase, and protochlorophyllide oxidoreductase (POR) were downregulated under low temperatures. Further investigations showed that chloroplasts at 18 °C had loose granum lamellae, while the thylakoid and lamellar structures of grana could hardly develop at 12 °C after 48 h of greening. Additionally, photosystem II (PSII) and photosystem I (PSI) proteins obviously declined in the stressed seedlings, to the point that the PSII and PSI proteins could hardly be detected after 48 h of greening at 12 °C. Furthermore, the accumulation of reactive oxygen species (ROS) and malondialdehyde (MDA) and cell death were all induced by low temperature. Chilling stress had no effect on the development of epidermis cells, but the stomata were smaller under chilling stress than those at 28 °C. Taken together, our study promotes more comprehensive understanding in that chilling could inhibit chlorophyll biosynthesis and cause oxidative damages during greening.
New Insights into the Role of Glutathione in the Mechanism of Fever
Authors: Wrotek Sylwia , Sobocińska Justyna , Kozłowski Henryk M. , Pawlikowska Małgorzata , Jędrzejewski Tomasz , Dzialuk Artur
Published: February 2020

Glutathione is one of the most important and potent antioxidants. The development of pharmacological compounds that can either increase or decrease glutathione concentrations has allowed investigation into the role of glutathione in various biological processes, including immune responses. Recent findings have shown that glutathione not only affects certain factors involved in immunological processes but also modifies complex immune reactions such as fever. Until recently, it was not known why some patients do not develop fever during infection. Data suggest that fever induction is associated with oxidative stress; therefore, antioxidants such as glutathione can reduce pyrexia. Surprisingly, new studies have shown that low glutathione levels can also inhibit fever. In this review, we focus on recent advances in this area, with an emphasis on the role of glutathione in immune responses accompanied by fever. We describe evidence showing that disturbed glutathione homeostasis may be responsible for the lack of fever during infections. We also discuss the biological significance of the antipyretic effects produced by pharmacological glutathione modulators.
Integrative Analysis of Circulating Metabolite Profiles and Magnetic Resonance Imaging Metrics in Patients with Traumatic Brain Injury
Authors: Thomas Ilias , Dickens Alex M. , Posti Jussi P. , Mohammadian Mehrbod , Ledig Christian , Takala Riikka S. K. , Hyötyläinen Tuulia , Tenovuo Olli , Orešič Matej
Published: February 2020

Recent evidence suggests that patients with traumatic brain injuries (TBIs) have a distinct circulating metabolic profile. However, it is unclear if this metabolomic profile corresponds to changes in brain morphology as observed by magnetic resonance imaging (MRI). The aim of this study was to explore how circulating serum metabolites, following TBI, relate to structural MRI (sMRI) findings. Serum samples were collected upon admission to the emergency department from patients suffering from acute TBI and metabolites were measured using mass spectrometry-based metabolomics. Most of these patients sustained a mild TBI. In the same patients, sMRIs were taken and volumetric data were extracted (138 metrics). From a pool of 203 eligible screened patients, 96 met the inclusion criteria for this study. Metabolites were summarized as eight clusters and sMRI data were reduced to 15 independent components (ICs). Partial correlation analysis showed that four metabolite clusters had significant associations with specific ICs, reflecting both the grey and white matter brain injury. Multiple machine learning approaches were then applied in order to investigate if circulating metabolites could distinguish between positive and negative sMRI findings. A logistic regression model was developed, comprised of two metabolic predictors (erythronic acid and myo-inositol), which, together with neurofilament light polypeptide (NF-L), discriminated positive and negative sMRI findings with an area under the curve of the receiver-operating characteristic of 0.85 (specificity = 0.89, sensitivity = 0.65). The results of this study show that metabolomic analysis of blood samples upon admission, either alone or in combination with protein biomarkers, can provide valuable information about the impact of TBI on brain structural changes.
Molecular Recognition and Advances in Antibody Design and Antigenic Peptide Targeting
Authors: Houen Gunnar , Trier Nicole
Published: February 2020

Molecular recognition, the specific interaction between molecules by a combination of physical forces, has been a subject of scientific investigation for decades [...]
Neuromuscular Diseases Due to Chaperone Mutations: A Review and Some New Results
Authors: Sarparanta Jaakko , Jonson Per Harald , Kawan Sabita , Udd Bjarne
Published: February 2020

Skeletal muscle and the nervous system depend on efficient protein quality control, and they express chaperones and cochaperones at high levels to maintain protein homeostasis. Mutations in many of these proteins cause neuromuscular diseases, myopathies, and hereditary motor and sensorimotor neuropathies. In this review, we cover mutations in DNAJB6, DNAJB2, αB-crystallin (CRYAB, HSPB5), HSPB1, HSPB3, HSPB8, and BAG3, and discuss the molecular mechanisms by which they cause neuromuscular disease. In addition, previously unpublished results are presented, showing downstream effects of BAG3 p.P209L on DNAJB6 turnover and localization.
Brain Metastases in Lung Cancers with Emerging Targetable Fusion Drivers
Authors: Tan Aaron C. , Itchins Malinda , Khasraw Mustafa
Published: February 2020

The management of non-small cell lung cancer (NSCLC) has transformed with the discovery of therapeutically tractable oncogenic drivers. In addition to activating driver mutations, gene fusions or rearrangements form a unique sub-class, with anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) targeted agents approved as the standard of care in the first-line setting for advanced disease. There are a number of emerging fusion drivers, however, including neurotrophin kinase (NTRK), rearrangement during transfection (RET), and neuregulin 1 (NRG1) for which there are evolving high-impact systemic treatment options. Brain metastases are highly prevalent in NSCLC patients, with molecularly selected populations such as epidermal growth factor receptor (EGFR) mutant and ALK-rearranged tumors particularly brain tropic. Accordingly, there exists a substantial body of research pertaining to the understanding of brain metastases in such populations. Little is known, however, on the molecular mechanisms of brain metastases in those with other targetable fusion drivers in NSCLC. This review encompasses key areas including the biological underpinnings of brain metastases in fusion-driven lung cancers, the intracranial efficacy of novel systemic therapies, and future directions required to optimize the control and prevention of brain metastases.
Comparative Proteomic Analysis of Wild-Type Physcomitrella Patens and an OPDA-Deficient Physcomitrella Patens Mutant with Disrupted PpAOS1 and PpAOS2 Genes after Wounding
Authors: Luo Weifeng , Komatsu Setsuko , Abe Tatsuya , Matsuura Hideyuki , Takahashi Kosaku
Published: February 2020

Wounding is a serious environmental stress in plants. Oxylipins such as jasmonic acid play an important role in defense against wounding. Mechanisms to adapt to wounding have been investigated in vascular plants; however, those mechanisms in nonvascular plants remain elusive. To examine the response to wounding in Physcomitrella patens, a model moss, a proteomic analysis of wounded P. patens was conducted. Proteomic analysis showed that wounding increased the abundance of proteins related to protein synthesis, amino acid metabolism, protein folding, photosystem, glycolysis, and energy synthesis. 12-Oxo-phytodienoic acid (OPDA) was induced by wounding and inhibited growth. Therefore, OPDA is considered a signaling molecule in this plant. Proteomic analysis of a P. patens mutant in which the PpAOS1 and PpAOS2 genes, which are involved in OPDA biosynthesis, are disrupted showed accumulation of proteins involved in protein synthesis in response to wounding in a similar way to the wild-type plant. In contrast, the fold-changes of the proteins in the wild-type plant were significantly different from those in the aos mutant. This study suggests that PpAOS gene expression enhances photosynthesis and effective energy utilization in response to wounding in P. patens.
Redox Components: Key Regulators of Epigenetic Modifications in Plants
Authors: R. M. Saravana Kumar , Wang Yibin , Zhang Xiaopan , Cheng Hui , Sun Lirong , He Shibin , Hao Fushun
Published: February 2020

Epigenetic modifications including DNA methylation, histone modifications, and chromatin remodeling are crucial regulators of chromatin architecture and gene expression in plants. Their dynamics are significantly influenced by oxidants, such as reactive oxygen species (ROS) and nitric oxide (NO), and antioxidants, like pyridine nucleotides and glutathione in plants. These redox intermediates regulate the activities and expression of many enzymes involved in DNA methylation, histone methylation and acetylation, and chromatin remodeling, consequently controlling plant growth and development, and responses to diverse environmental stresses. In recent years, much progress has been made in understanding the functional mechanisms of epigenetic modifications and the roles of redox mediators in controlling gene expression in plants. However, the integrated view of the mechanisms for redox regulation of the epigenetic marks is limited. In this review, we summarize recent advances on the roles and mechanisms of redox components in regulating multiple epigenetic modifications, with a focus of the functions of ROS, NO, and multiple antioxidants in plants.
Evaporation Modeling of Water Droplets in a Transonic Compressor Cascade under Fogging Conditions
Authors: Seck Adrian , Geist Silvio , Harbeck Janneck , Weigand Bernhard , Joos Franz
Published: February 2020

High-fogging is widely used to rapidly increase the power outputs of stationary gas turbines. Therefore, water droplets are injected into the inflow air, and a considerable number enter the compressor. Within this paper, the primary process of droplet evaporation is investigated closely. A short discussion about the influential parameters ascribes a major significance to the slip velocity between ambient gas flow and droplets. Hence, experimental results from a transonic compressor cascade are shown to evaluate the conditions in real high-fogging applications. The measured parameter range is used for direct numerical simulations to extract evaporation rates depending on inflow conditions and relative humidity of the air flow. Finally, an applicable correlation for the Sherwood number in the form of S h ( R e 1 / 2 S c 1 / 3 ) is suggested.
Sensitivity of Planaria to Weak, Patterned Electric Current and the Subsequent Correlative Interactions with Fluctuations in the Intensity of the Magnetic Field of Earth
Authors: Hossack Victoria , Persinger Michael , Dotta Blake
Published: February 2020

Some species of fish show highly evolved mechanisms by which they can detect exogenous electric and magnetic fields. The detection of electromagnetic fields has been hypothesized to exist in humans, despite the lack of specialized sensors. In this experiment, planaria were tested in a t-maze with weak electric current pulsed in one arm to determine if the planaria showed any indication of being able to detect it. It was found that a small proportion of the population seemed to be attracted to this current. Additionally, if the experiment was preceded by a geomagnetic storm, the planaria showed a linear correlation increase in the variability of their movement in response to the presence of the weak electric field. Both of these results indicate that a subpopulation of planaria show some ability to respond to electromagnetic fields.
A Methodology to Parameterize Wire + Arc Additive Manufacturing: A Case Study for Wall Quality Analysis
Authors: Dahat Shubham , Hurtig Kjell , Andersson Joel , Scotti Americo
Published: February 2020

The objective of this work was the development of a methodology to parametrize wire + arc additive manufacturing (WAAM), aiming dimension repeatability, and tolerances. Parametrization of WAAM is a difficult task, because multiple parameters are involved and parameters are inter-dependent on each other, making overall process complex. An approach to study WAAM would be through operational maps. The choice of current (Im) and travel speed (TS) for the desirable layer width (LW) determines a parametrization that leads to either more material or less material to be removed in post-operations, which is case study chosen for this work. The work development had four stages. First stage, named ‘mock design’, had the objective of visualizing the expected map and reduce further number of experiments. At the second stage, ‘pre-requisite for realistic operational map’, the objective was to determine the operating limits of TS and Im with the chosen consumables and equipment. Within the ‘realistic operational map’ stage, a design for the experiments was applied to cover a parametric area (working envelope) already defined in the previous stage and long and tall walls were additively manufactured. Actual values of LW (external and effective layer width) were measured and an actual operating envelope was reached. According to the geometry-oriented case study, a surface waviness index (SWindex) was defined, determined, and overlapped in the envelope. It was observed that the walls with parameters near the travel speed limits presented higher SWindex. This operational map was further validated (fourth stage) by selecting a target LW and finding corresponding three parametric set (covering the whole range of operational map) to produce walls on which geometry characterization was carried out. After geometry characterization, obtained LW was compared with the target LW (the maximum values were very tied, with deviations from +0.3 to 0.5 mm), with a SWindex deviation at the order of 0.05. Both results evidence high reproductivity of the process, validating the proposed methodology to parametrize WAAM.
A Comprehensive Review of Corporate Bankruptcy Prediction in Hungary
Authors: Kristóf Tamás , Virág Miklós
Published: February 2020

The article provides a comprehensive review regarding the theoretical approaches, methodologies and empirical researches of corporate bankruptcy prediction, laying emphasis on the 30-year development history of Hungarian empirical results. In ex-socialist countries corporate bankruptcy prediction became possible more than 20 years later compared to the western countries, however, based on the historical development of corporate bankruptcy prediction after the political system change it can be argued that it has already caught up to the level of international best practice. Throughout the development history of Hungarian bankruptcy prediction, it can be tracked how the initial, small, cross-sectional sample and classic methodology-based bankruptcy prediction has evolved to today’s corporate rating systems meeting the requirements of the dynamic, through-the-cycle economic capital calculation models. Contemporary methodological development is characterized by the domination of artificial intelligence, data mining, machine learning, and hybrid modelling. On the basis of empirical results, the article draws several normative proposals how to assemble a bankruptcy prediction database and select the right classification method(s) to accomplish efficient corporate bankruptcy prediction.
Investigation of Penetration Performance of Zr-based Amorphous Alloy Liner Compared with Copper
Authors: Cui Ping , Wang Deshi , Shi Dongmei , Gao Xinbao , Xu Jingqing , Zhen Jianwei
Published: February 2020

Zr-based amorphous alloy is a new type of metastable energetic material, which has been exploringly used to design shaped charge (SC) liners by scholars of the military industry. In order to know well how the stand-off distance influences jet penetration performance of liners made by such energetic materials against metal targets, SC static explosion tests were conducted under the same initiation and target conditions but different stand-off distances compared with copper liners. Test results indicate that the jet depth of penetration (DOP) of Zr-based amorphous alloy liners firstly increases slowly and then decreases sharply as the stand-off becomes larger. The optimum stand-off distance is 3.5 times of charge diameter (CD) and the corresponding maximum DOP is about 2.68 CD against the 45# steel plate. The perforation area varies with the stand-off distance. It reaches the maximum when the stand-off is 3.5 CD and the corresponding perforation diameter is about 42mm, also the penetration hole is nearly circular. The jet DOP of Zr-based amorphous alloy liner is smaller than that of copper liner’s while the perforation area is the opposite. The former DOP is about 55.7% of the latter and the former perforation area is about 2.8 times of latter when the stand-off distance is 3.5 CD.
Effect of a Trace Addition of Sn on the Aging Behavior of Al–Mg–Si Alloy with a Different Mg/Si Ratio
Authors: Ma Lehang , Tang Jianguo , Tu Wenbin , Ye Lingying , Jiang Haichun , Zhan Xin , Zhao Jiuhui
Published: February 2020

In this paper, the effect of trace Sn on the precipitation behavior and mechanical properties of Al–Mg–Si alloys with different Mg/Si ratios aged at 180 °C was investigated using hardness measurements, a room-temperature tensile test, transmission electron microscopy and differential scanning calorimetry. The results shown that Sn reduces the precipitation activation energy, increases the number density of β″ precipitates, and then increased the aging hardenability and mechanical properties of the Al–Mg–Si alloy. However, the positive effect of Sn on the mechanical properties of the Al–Mg–Si alloy drops with the decrease of the Mg/Si ratio of the alloy.
Characterization of Recovery in Asphalt Binders
Authors: Ma Fuquan , Luo Xue , Huang Zhiyi , Wang Jinchang
Published: February 2020

The recovery property of asphalt binders plays an important role in the performance and service life of asphalt pavements. Since the internal stress is the driving force for the recovery of asphalt binders, the accurate measurement of the internal stress is full of significance. Based on this rationale, this paper aims to measure the internal stress of asphalt binders using a creep and step-loading recovery (CSR) test and characterizing the recovery behaviors by the internal stress. One base asphalt binder and one styrene–butadiene–styrene (SBS)-modified binder are selected in this study. The key elements of the CSR test are carefully designed and its accuracy is verified in three aspects, including the loading conditions, the effect of disturbance by step-loads, and accuracy of measured internal stress. Then, a kinetics-based recovery model is proposed to evaluate and predict the recovery properties of asphalt binders from its causal relationship. The constant-rate recovery activation energy indicates a major difference with nondestructive and destructive loading conditions, while the fast-rate recovery activation energy keeps almost constant regardless of the loading conditions. After that, the healing activation energy is calculated by using the kinetics-based recovery model and the results indicate that SBS modified asphalt binder shows better healing abilities than a base binder.
Functionalized Microstructured Optical Fibers: Materials, Methods, Applications
Authors: Ermatov Timur , Skibina Julia S. , Tuchin Valery V. , Gorin Dmitry A.
Published: February 2020

Microstructured optical fiber-based sensors (MOF) have been widely developed finding numerous applications in various fields of photonics, biotechnology, and medicine. High sensitivity to the refractive index variation, arising from the strong interaction between a guided mode and an analyte in the test, makes MOF-based sensors ideal candidates for chemical and biochemical analysis of solutions with small volume and low concentration. Here, we review the modern techniques used for the modification of the fiber’s structure, which leads to an enhanced detection sensitivity, as well as the surface functionalization processes used for selective adsorption of target molecules. Novel functionalized MOF-based devices possessing these unique properties, emphasize the potential applications for fiber optics in the field of modern biophotonics, such as remote sensing, thermography, refractometric measurements of biological liquids, detection of cancer proteins, and concentration analysis. In this work, we discuss the approaches used for the functionalization of MOFs, with a focus on potential applications of the produced structures.
Beamless Metal Additive Manufacturing
Authors: Vaezi Mohammad , Drescher Philipp , Seitz Hermann
Published: February 2020

The propensity to manufacture functional and geometrically sophisticated parts from a wide range of metals provides the metal additive manufacturing (AM) processes superior advantages over traditional methods. The field of metal AM is currently dominated by beam-based technologies such as selective laser sintering (SLM) or electron beam melting (EBM) which have some limitations such as high production cost, residual stress and anisotropic mechanical properties induced by melting of metal powders followed by rapid solidification. So, there exist a significant gap between industrial production requirements and the qualities offered by well-established beam-based AM technologies. Therefore, beamless metal AM techniques (known as non-beam metal AM) have gained increasing attention in recent years as they have been found to be able to fill the gap and bring new possibilities. There exist a number of beamless processes with distinctively various characteristics that are either under development or already available on the market. Since this is a very promising field and there is currently no high-quality review on this topic yet, this paper aims to review the key beamless processes and their latest developments.
Liquid Phase Hydrogenation of Pharmaceutical Interest Nitroarenes over Gold-Supported Alumina Nanowires Catalysts
Authors: Shanmugaraj Krishnamoorthy , Bustamante Tatiana M. , Campos Cristian H. , Torres Cecilia C.
Published: February 2020

In this work, Au nanoparticles, supported in Al2O3 nanowires (ANW) modified with (3-aminopropyl)trimethoxysilane were synthetized, for their use as catalysts in the hydrogenation reaction of 4-(2-fluoro-4-nitrophenyl)-morpholine and 4-(4-nitrophenyl)morpholin-3-one. ANW was obtained by hydrothermal techniques and the metal was incorporated by the reduction of the precursor with NaBH4 posterior to superficial modification. The catalysts were prepared at different metal loadings and were characterized by different techniques. The characterization revealed structured materials in the form of nanowires and a successful superficial modification. All catalysts show that Au is in a reduced state and the shape of the nanoparticles is spherical, with high metal dispersion and size distributions from 3.7 to 4.6 nm. The different systems supported in modified-ANW were active and selective in the hydrogenation reaction of both substrates, finding for all catalytic systems a selectivity of almost 100% to the aromatic amine. Catalytic data showed pseudo first-order kinetics with respect to the substrate for all experimental conditions used in this work. The solvent plays an important role in the activity and selectivity of the catalyst, where the highest efficiency and operational stability was achieved when ethanol was used as the solvent.
Morphology, Rheology and Crystallization in Relation to the Viscosity Ratio of Polystyrene/Polypropylene Polymer Blends
Authors: Hammani Salim , Moulai-Mostefa Nadji , Samyn Pieter , Bechelany Mikhael , Dufresne Alain , Barhoum Ahmed
Published: February 2020

Microfibrillar and droplet morphology of polypropylene (PP) phase dispersed in polypropylene (PS) was fabricated by using melt-extrusion. This morphology was obtained by introducing isotactic PP (20 wt.%) with different viscosity in the PS matrix (80 wt.%). Furthermore, the rheological properties of the blend investigated as a function of the viscosity ratio K. The variations in blend morphology were related to crystallization, melting properties, and viscoelasticity. The blends with K >> 1 develop a fine morphology with PP microfibrils along the flow direction, while diameters of the dispersed PP droplets gradually increase with lower values of K = 1, or K << 1. Crystallinity of the prepared blends significantly decreases compared to neat PP, while the microfibrillar morphology induces homogeneous crystallization with small crystallites. This is reflected in a decrease of the crystallization temperature, small loss in the crystallinity, and lower melting temperature of the PS80/PP20 blend compared to neat PP. The storage moduli, loss moduli, and complex viscosity are highest for the microfibrillar morphology that presents retarded relaxation. The rheological properties are dominated by the dispersed phase (K > 1), or matrix (K < 1). The variation in blend properties with microfibrillar morphology can be clearly distinguished from heterogeneous blends containing PP droplets, providing an efficient tool to create a binary blend with unique properties.
SBA-16 Cage-Like Porous Material Modified with APTES as an Adsorbent for Pb2+ Ions Removal from Aqueous Solution
Authors: Palos-Barba Viviana , Moreno-Martell Abigail , Hernández-Morales Verónica , Peza-Ledesma Carmen L. , Rivera-Muñoz Eric M. , Nava Rufino , Pawelec Barbara
Published: February 2020

Tridimensional cubic mesoporous silica, SBA-16, functionalized with aminopropyl groups, were employed as adsorbents for Pb2+ ion removal from aqueous solution. The adsorption capacity was investigated for the effect of pH, contact time, temperature, and concentration of 3-aminopropyltriethoxysilane (APTES) employed for adsorbent functionalization. The textural properties and morphology of the adsorbents were evaluated by N2 physisorption, small-angle X-ray diffraction (XRD), diffuse reflectance spectroscopy (UV-vis), and transmission electron microscopy (TEM). The functionalization of the SBA-16 was evaluated by elemental analysis (N), thermogravimetric analysis (TG), Fourier transform infrared spectroscopy (FT-IR), and X-ray photoelectron spectroscopy (XPS). Batch adsorption studies show that the total Pb2+ ions removal was archived on adsorbent having an optimized amount of aminopropyl groups (2N-SBA-16). The maximum of Pb2+ ions removal occurred at optimized adsorption conditions: pH = 5–6, contact time 40 min, and at a low initial lead concentration in solution (200 mg L−1). Under the same adsorption conditions, the amino-functionalized SBA-16 with cubic 3D unit cell structure exhibited higher adsorption capability than its SBA-15 counterpart with uniform mesoporous channels.
Bending Performance of Steel Fiber Reinforced Concrete Beams Based on Composite-Recycled Aggregate and Matched with 500 MPa Rebars
Authors: Li Xiaoke , Pei Songwei , Fan Kunpeng , Geng Haibin , Li Fenglan
Published: February 2020

To promote the engineering application of recycled aggregate for concrete production with good adaptability and economic efficiency, this paper performed a campaign to investigate the flexural performance of steel fiber reinforced composite-recycled aggregate concrete (SFR-CRAC) beams matched with 500 MPa longitudinal rebars. The composite-recycled aggregate has features of the full use recycled fine aggregate and small particle recycled coarse aggregate, and the continuous grading of coarse aggregate ensured by admixing the large particle natural aggregate about 35% to 45% in mass of total coarse aggregate. The properties of SFR-CRAC have been comprehensively improved by using steel fibers. With a varying volume fraction of steel fiber from 0% to 2.0%, 10 beam specimens were produced. The flexural behaviors of the beams during the complete loading procedure were experimentally studied under a four-point bending test. Of which the concrete strain at mid-span section, the appearance of cracks, the crack distribution and crack width, the mid-span deflection, the tensile strain of longitudinal rebars, and the failure patterns of the beams were measured in detail. Results indicated that the assumption of plane cross-section held true approximately, the 500 MPa longitudinal rebars worked at a high stress level within the limit width of cracks on reinforced SFR-CRAC beams at the normal serviceability, and the typical failure occurred with the yield of 500 MPa longitudinal rebars followed by the crushed SFR-CRAC in compression. The cracking resistance, the flexural capacity, and the flexural ductility of the beams increased with the volume fraction of steel fiber, while the crack width and mid-span deflection obviously decreased. Finally, by linking to those for conventional reinforced concrete beams, formulas are suggested for predicting the cracking moment, crack width, and flexural stiffness at normal serviceability, and the ultimate moment at bearing capacity of reinforced SFR-CRAC beams.
Bioactive Metabolites of Marine Origin Have Unusual Effects on Model Membrane Systems
Authors: Jakubec Martin , Totland Christian , Rise Frode , Chamgordani Elahe Jafari , Paulsen Britt , Maes Louis , Matheeussen An , Gundersen Lise-Lotte , Halskau Øyvind
Published: February 2020

Marine sponges and soft corals have yielded novel compounds with antineoplastic and antimicrobial activities. Their mechanisms of action are poorly understood, and in most cases, little relevant experimental evidence is available on this topic. In the present study, we investigated whether agelasine D (compound 1) and three agelasine analogs (compound 2–4) as well as malonganenone J (compound 5), affect the physical properties of a simple lipid model system, consisting of dioleoylphospahtidylcholine and dioleoylphosphatidylethanolamine. The data indicated that all the tested compounds increased stored curvature elastic stress, and therefore, tend to deform the bilayer which occurs without a reduction in the packing stress of the hexagonal phase. Furthermore, lower concentrations (1%) appear to have a more pronounced effect than higher ones (5–10%). For compounds 4 and 5, this effect is also reflected in phospholipid headgroup mobility assessed using 31P chemical shift anisotropy (CSA) values of the lamellar phases. Among the compounds tested, compound 4 stands out with respect to its effects on the membrane model systems, which matches its efficacy against a broad spectrum of pathogens. Future work that aims to increase the pharmacological usefulness of these compounds could benefit from taking into account the compound effects on the fluid lamellar phase at low concentrations.
Characterization of a New Chitosanase from a Marine Bacillus sp. and the Anti-Oxidant Activity of Its Hydrolysate
Authors: Ma Chunrui , Li Xiao , Yang Kun , Li Shangyong
Published: February 2020

Chitooligosaccharide (COS) has been recognized to exhibit efficient anti-oxidant activity. Enzymatic hydrolysis using chitosanases can retain all the amino and hydroxyl groups of chitosan, which are necessary for its activity. In this study, a new chitosanase encoding gene, csnQ, was cloned from the marine Bacillus sp. Q1098 and expressed in Escherichia coli. The recombinant chitosanase, CsnQ, showed maximal activity at pH 5.31 and 60 °C. Determination of CsnQ pH-stability showed that CsnQ could retain more than 50% of its activity over a wide pH, from 3.60 to 9.80. CsnQ is an endo-type chitosanase, yielding chitodisaccharide as the main product. Additionally, in vitro and in vivo analyses indicated that chitodisaccharide possesses much more effective anti-oxidant activity than glucosamine and low molecular weight chitosan (LMW-CS) (~5 kDa). Notably, to our knowledge, this is the first evidence that chitodisaccharide is the minimal COS fragment required for free radical scavenging.
Comparison of Lateral Abdominal Musculature Activation during Expiration with an Expiratory Flow Control Device Versus the Abdominal Drawing-in Maneuver in Healthy Women: A Cross-Sectional Observational Pilot Study
Authors: Abuín-Porras Vanesa , Maldonado-Tello Paula , de la Cueva-Reguera Mónica , Rodríguez-Sanz David , Calvo-Lobo César , López-López Daniel , Navarro-Flores Emmanuel , Romero-Morales Carlos
Published: February 2020

Background and Objectives: The purpose of the present study was to quantify and compare lateral abdominal musculature thickness, including the transverse abdominis (TrA), internal oblique (IO), and external oblique (EO) muscles, via rehabilitative ultrasound imaging (RUSI) during the use of the expiratory flow control device (EFCD) versus the classic abdominal drawing-in maneuver (ADIM). Materials and Methods: A cross-sectional observational pilot study. Twenty-one women were recruited and assessed the thickness of each muscle (TrA, IO, and EO) by ultrasound imaging at rest, during the ADIM, and during expiration with the EFCD. Waist circumference was also measured under the same circumstances. Results: Statistically significant differences were observed between ADIM, EFCD, and at rest condition for the thickness of the TrA (p = 0.001) and IO (p = 0.039). Moreover, statistically significant differences for TrAb at rest compared with the ADIM (p = 0.001, Cohen’s d = 2.183) and at rest and with the EFCD (p = 0.001, Cohen’s d = 2.843). In addition, between ADIM and EFCD were not statistically significant, although a moderate effect size was found (p = 0.055, Cohen’s d = 0.694). For the IO muscle thickness, significant differences were reported between the EFCD and at rest (p = 0.038), Cohen’s d = 0.081). Conclusions: Significant differences in the increase of the thickness of the TrA and IO muscles during the use of the EFCD and the ADIM with respect to rest. In addition, for the TrA, statistically significant differences were found during expiration with the EFCD with respect to the ADIM. Expiration with EFCD can be a useful method for the activation of the TrA.
Sheet Metal Forming Optimization Methodology for Servo Press Process Control Improvement
Authors: Del Prete Antonio , Primo Teresa
Published: February 2020

In sheet metal forming manufacturing operations the use of servo presses is gaining more interest due to the opportunity to improve process performance (quality, productivity, cost reduction, etc.). It is not yet clear how to proceed in the engineering process when this type of operating machine is used to achieve the maximum possible potential of this technology. Recently, several press builders have developed gap- and straight-sided metal forming presses adopting the mechanical servo-drive technology. The mechanical servo-drive press offers the flexibility of a hydraulic press with the speed, accuracy and reliability of a mechanical press. Servo drive presses give the opportunity to improve the productivity of process conditions and improve the quality of stamped parts. Forming simulation and numerical optimization can be useful tools to define beforehand the optimal process parameter set-up in terms of servo press downward curve properties. This is done by carrying out a sensitivity analysis of the forming parameters having influence on said curve. The authors have developed a numerical methodology able to analyze the influence factors, for comparison with the degrees of freedom made available by the usage of a servo press, in terms of stroke profile management, to obtain an optimized process parameters combination.
Additive Manufacturing with Superduplex Stainless Steel Wire by CMT Process
Authors: Lervåg Malin , Sørensen Camilla , Robertstad Andreas , Brønstad Bård M. , Nyhus Bård , Eriksson Magnus , Aune Ragnhild , Ren Xiaobo , Akselsen Odd M. , Bunaziv Ivan
Published: February 2020

For many years, the oil and gas industry has utilized superduplex stainless steels due to their high strength and excellent corrosion resistance. Wire arc additive manufacturing (WAAM) was used with superduplex filler wire to create walls with different heat input. Due to the multiple heating and cooling cycles during layer deposition, brittle secondary phases may form such as intermetallic sigma (σ) phase. By inspecting deposited walls within wide range of heat inputs (0.40–0.87 kJ/mm), no intermetallic phases formed due to low inter-pass temperatures used, together with the high Ni content in the applied wire. Lower mechanical properties were observed with high heat inputs due to low ferrite volume fraction, precipitation of Cr nitrides and formation of secondary austenite. The walls showed good toughness values based on both Charpy V-notch and CTOD (crack tip opening displacement) testing.
In Situ Measurements for Plastic Zone Ahead of Crack Tip and Continuous Strain Variation under Cyclic Loading Using Digital Image Correlation Method
Authors: Zhao Yan , Hu Dianyin , Zhang Meng , Dai Wei , Zhang Weifang
Published: February 2020

Fatigue crack is one of the most common damage forms for aeronautical aluminum alloy. With crack propagation, the strain fields of the whole object surface and plastic zone (PZ) ahead of the crack tip are changing continuously. For most metallic materials, the behavior of PZ around the crack tip and continuous strain variation play a vital role in crack propagation. In this work, the “continuous” strain information at and in front of the crack tip on the specimen surface was obtained quantitatively and the PZ size ahead of crack tip was in situ measured quantitatively with crack propagation by using the digital image correlation (DIC) method, which overcomes the difficulty for the in situ measurement of mechanical variables. Moreover, the method of specimen preparation was simplified by using a white matt paint with strong adhesion, but also resulted in a higher resolution being shown, even for such a large area. Furthermore, the experimental results of the PZ size from the proposed method had good agreement with the theoretical values, which overcomes the limitation that the conventional approaches only consider the quasi-static crack. Finally, the continuous strain variation behavior was analyzed from the experimental results in detail with the consideration of crack propagation.