bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluación de la función psicosocial y la calidad de vida en pacientes diagnosticados de TDAH en respuesta a psicoestimulantes
Authors: Concepción González P. , Monzón Díaz J. , Quantd Herrera P. , Girbau Ronda JP. , Rubio Morell B. , Henry Benítez M.
Published: February 2019

Introducción: A pesar de que los tratamientos establecidos para mejorar los síntomas del TDAH han demostrado alivio sintomático significativo, es poco lo que se conoce sobre el efecto de los psicoestimulantes sobre el desarrollo psicosocial del niño y la potencial mejoría del deterioro funcional del paciente en todos los ámbitos de su vida diaria.

Objetivos: El objetivo principal de este estudio es evaluar el impacto del tratamiento farmacológico con psicoestimulantes en el deterioro funcional, las dificultades psicosociales y la calidad de vida de los pacientes diagnosticados de TDAH.

Material y métodos: Se realizó un estudio descriptivo, prospectivo, de una serie de casos, donde la población de estudio fueron 13 niños de entre 6 y 16 años, diagnosticados de TDAH en el Complejo Hospitalario Universitario de Canarias y que requerían comenzar tratamiento farmacológico con psicoestimulantes (Metilfenidato). El deterioro funcional y la calidad de vida fueron evaluados en respuesta al tratamiento pautado mediante dos instrumentos de valoración psicológica específicos para este trastorno: la Escala de Impresión Global de las Dificultades Percibidas (GIPD) y la Escala de Clasificación del Deterioro Funcional de Weiss (WFIRS).

Resultados: La evaluación de la puntuación total de las escalas GIPD y WFIRS efectuadas por los padres mostró mejoría en el desarrollo psicosocial entre el momento previo al tratamiento y tras ocho semanas de terapia farmacológica psicoestimulante. El estudio estadístico mostró un p-valor =0,000241 para las dificultades percibidas con la escala GIPD y un p =0,000152 para los cambios percibidos con la escala WFIRS, mostrando, por tanto, diferencias estadísticamente significativas.

Conclusión: En función de las respuestas de los padres obtenidas en las escalas, establecemos que los beneficios del tratamiento diario con psicoestimulantes en los niños con TDAH se extienden más allá del alivio de los síntomas e impacta positivamente en la función psicosocial diaria de los pacientes, así como en su calidad de vida.
Antioxidative, hypoglycaemic and hepatoprotective properties of five Vaccinium spp. berry pomace extracts
Authors: Muceniece Ruta , Klavins Linards , Kviesis Jorens , Jekabsons Kaspars , Rembergs Reinis , Saleniece Kristine , Dzirkale Zane , Saulite Liga , Riekstina Una , Klavins Maris
Published: February 2019

BACKGROUND:

Berry pomaces contain biologically active substances and therefore may have considerable potential applications in food and pharmaceutical industries. However, there is a lack of studies on extracting these valuable products from berry pomaces.

OBJECTIVE:

This study aims to evaluate major constituents of five Vaccinium spp. berry pomace extracts and investigate their antioxidant, hypoglycaemic and hepatoprotective properties.

METHODS:

Total anthocyanin, procyanidin and polyphenol contents in berry residues were measured by spectrophotometric pH-differential, 4-dimethylaminocinnamaldehyde and Folin–Ciocalteu method, respectively. Identification and quantification of separate compounds were assessed by ultra-performance liquid chromatography and liquid chromatography-time-of-flight-masspectroscopy. Anti-hyperglycaemic properties of pomace extracts were evaluated based on inhibition of α-amylase and α-glucosidase activity. Extract hepatoprotective effects were estimated based on increased human hepatic cell line HepG2 viability in oxidative stress conditions.

RESULTS:

The extracts possessed strong antioxidant effects and efficacy for inhibiting the activities of enzymes involved in carbohydrate digestion and for protecting hepatic cells from oxidative damage.

CONCLUSIONS:

Hepatoprotective and hypoglycaemic properties of berry pomace extracts may be due to the presence of active polyphenols and their synergistic effects. Our results support the use of berry pomaces for designing standardised formulations for the prevention of chronic diseases associated with oxidative stress.
Perfil Clínico-epidemiológico de Crianças e Adolescentes com Câncer em um Serviço de Oncologia
Authors: Mutti Cintia Flôres , Cruz Vanessa Gomes da , Santos Leidiene Ferreira , Araújo Daiana de , Cogo Silvana Bastos , Neves Eliane Tatsch
Published: February 2019

Introdução: O progresso no controle do câncer nos últimos 50 anos é inegável; entretanto, no Brasil, ele ainda representa a segunda causa de morte na população infantojuvenil, e estudos não têm evidenciado declínio desses dados. Objetivo: Analisar o perfil clínico--epidemiológico de crianças e adolescentes com câncer em um Serviço de Oncologia. Método: Estudo documental retrospectivo, com busca de dados em prontuários de crianças e adolescentes, com diagnóstico de câncer no período de 2008 a 2014. Os dados foram coletados no período de maio a agosto de 2015, armazenados em banco de dados informatizado e submetidos à análise estatística descritiva. Este estudo foi aprovado pelo Comitê de Ética em Pesquisa da Universidade Federal do Tocantins (protocolo 116/2014). Resultados: A idade média ao diagnóstico foi de 8 anos, sendo a maioria do sexo masculino; e os tipos de câncer mais frequentes foram as leucemias, linfomas e os tumores do sistema nervoso central. O uso da quimioterapia predominou entre os tratamentos utilizados. Referente à situação-esfecho, obtiveram alta por cura (11%); em tratamento (14%); acompanhamento pós-tratamento (31%); e foram  a óbito (29%). Conclusão: O perfil de crianças e adolescentes com câncer deste estudo denotou a complexidade e a dimensão biopsicossocial, que envolveram a terapêutica do câncer infantojuvenil, traduzidas pelo número expressivo de internações hospitalares e óbitos em crianças menores de 5 anos. Recomenda-se a capacitação dos profissionais de saúde para a realização do diagnótico precoce e para a excelência do tratamento multiprofissional em busca não só da cura, mas também da qualidade de vida.
Avaliação da Força de Preensão Palmar e Qualidade de Vida de Crianças com Câncer Submetidas à Quimioterapia com Vincristina
Authors: Costa Thayze Bairros da , Frantzeski Michelle Hagi , Nascimento Daniela Meirelles do , Gregianin Lauro José
Published: February 2019

Introdução: Com a quimioterapia, os pacientes podem apresentar diversas alterações; entre elas, polineuropatia e mudança na qualidade de vida, tanto à criança como aos familiares. Objetivo: Avaliar a força de preensão palmar e a qualidade de vida de crianças e adolescentes com câncer submetidos à quimioterapia com vincristina. Método: Trata-se de um estudo, no qual os pacientes responderam aos questionários de anamnese e PedsQLTM 3.0 Câncer Module, em três momentos diferentes do tratamento. Um dos seus responsáveis foi convidado a responder ao mesmo questionário. A força de preensão palmar foi aferida por meio de um dinamômetro, nos mesmos momentos. Resultados: A amostra foi composta por sete pacientes com mediana 7 (5-15 anos); com predomínio de meninas, residentes em Porto Alegre, RS, e diagnóstico prevalente de leucemia linfoide aguda, internados na primeira semana após o diagnóstico de câncer. A força de preensão palmar apresentou redução significativa para ambos os membros (p=0,018, membro superior direito; p=0,030, membro superior esquerdo). Apesar de não apresentar resultado significativo, na maioria dos domínios do questionário de qualidade de vida, ocorreu declínio nas respostas, principalmente nas dos pais. Conclusão: A quimioterapia com vincristina reduz a força muscular periférica em pacientes com câncer, nos 30 primeiros dias. Em relação à qualidade de vida, não foi apresentada diferença significativa. Porém, dentro dos domínios, pôde-se perceber algumas alterações. Sendo assim, fica clara a importância do acompanhamento contínuo da fisioterapia junto a uma equipe preparada para esses pacientes e seus familiares.
Formação, Treinamento e Aperfeiçoamento em Oncologia Infantojuvenil no Âmbito do Programa Nacional de Apoio à Atenção Oncológica: um Panorama do Triênio 2016-2018
Authors: Rezende Vanessa Murta , Neves Gabriela Furtado
Published: February 2019

Introdução: O Programa Nacional de Apoio à Atenção Oncológica (Pronon) é fruto de uma parceria entre os Ministérios da Saúde e da Fazenda, que, conjuntamente, determinam um valor global de renúncia fiscal a ser empregada a cada período. Entre os temas prioritários do programa, tem-se a oncologia infantojuvenil e é possível a submissão de projetos, pelas instituições de saúde do Terceiro Setor, nas áreas de assistência, pesquisa e formação profissional. Objetivo: Apresentar um panorama do triênio 2016-2018, referente aos projetos voltados para essa temática, na área de formação, treinamento e aperfeiçoamento de recursos humanos. Método: Estudo de caso e análise qualiquantitativa, tendo como amostra todos os projetos apresentados ao Ministério da Saúde, no âmbito do Pronon, no período. Resultados: Foi possível observar que o número de projetos apresentados na esfera do Pronon, na temática de oncologia infantojuvenil, é muito baixo, representando 14,28% do total de projetos expostos no triênio e, destes, somente um foi aprovado. Conclusão: Conclui-se que há uma carência de projetos tanto apresentados como aprovados envolvendo essa temática. Dessa forma, busca-se incentivar as instituições do Terceiro Setor que atuam na prestação de serviços oncológicos a participarem do programa por meio de projetos com capacidade técnica operacional, considerados de relevância para o Sistema Único de Saúde e seus usuários.
Terapia Nutricional de Pacientes com Câncer Infantojuvenil submetidos a Transplante de Células-Tronco Hematopoiéticas
Authors: Garófolo Adriana , Nakamura Claudia Harumi
Published: February 2019

Introdução: O estado nutricional é fortemente afetado pelo processo de transplante de células-tronco hematopoiéticas (TCTH). Os distúrbios nutricionais em pacientes TCTH são comuns e  são consequência da doença primária, da terapia de citorredução realizada durante o regime de condicionamento e das suas complicações, como as infecções, enterocolite neutropênica, doença do enxerto contra o hospedeiro, entre outras. Objetivo: Realizar uma revisão narrativa com base nos principais estudos e posicionamento de experts na literatura, somado à experiência do nosso grupo. Método: Levantamento bibliográfico dos principais estudos e consensos sobre os temas terapia nutricional, paciente oncológico, paciente oncológico pediátrico e transplante TCTH. Resultados: O estado nutricional e a oferta nutricional deficientes podem influenciar negativamente a função imune durante o estresse metabólico, aumentando o risco de complicações e desfavorecendo o prognóstico. Propostas de intervenção nutricional e as principais recomendações para a terapia de nutrição oral, enteral e parenteral foram revisadas. Dois algoritmos foram desenvolvidos, baseados nos resultados da revisão, discriminando as fases do TCTH, com a finalidade de facilitar a decisão da terapia nutricional. Conclusão: Existem poucas evidências para embasar as recomendações nutricionais e a terapia nutricional para crianças e adolescentes submetidos ao TCTH. Muitas informações são baseadas em estudos com adultos ou população pediátrica oncológica em tratamento antineoplásico comum. Há necessidade de ensaios clínicos controlados para avaliar a aplicabilidade e os benefícios da terapia nutricional em pacientes pediátricos submetidos a TCTH.
O Câncer Infantojuvenil nas Políticas Públicas no Estado do Rio de Janeiro, 2013-2021
Authors: Pires Laurenice de Jesus Alves
Published: February 2019

Este artigo avalia como as principais políticas de câncer e o Plano de Atenção Oncológica do estado do Rio de Janeiro se referem às nove ações indicadas por especialistas para alcançar maiores chances de cura.
Statistical Analysis of Study Abroad Experiences of International Students in Five Major Host Countries of Europe
Authors: Mikuláš Josek , Jitka Svobodová
Published: February 2019

This paper examines a large dataset of questionnaire responses (n=5,321) of international students who have studied abroad (mainly via the Erasmus+ programme). Their acculturation experiences with campus discrimination (an acculturative stressor), academic support (a mediator of acculturation) and academic satisfaction (an outcome of acculturation) are analyzed and compared among five European countries (France, Germany, Italy, Spain, and Portugal). The measures of acculturation experiences are verified by Principal Component Analysis, which yields three components; Campus Discrimination, Academic Support, and Academic Satisfaction. The components are used as aggregate indexes for ranking the five major destination countries in Europe based on students’ experiences. A country-by-country comparison suggests that experiences from study abroad are most positive in Germany.
'AWRAT
Authors: Hudaeri Mohamad
Published: February 2019

Meskipun kata-kata 'awrat begitu akrab di telinga kita, tetapi pengetahuan mengenai definisi dan batasannya sering tidak jelas. hal ini disebabkan oleh pemaknaan kata 'awrat yang tidak hanya dimaknai sebagai bagian-bagain tubuh manusia yang harus ditutup tetapi juga terkait dengan relasi kuasa antara laki-laki dan perempuan. Keharusan untuk menutup bagian-bagian tubuh terlentu bermakna juga untuk mengendalikan dan bersubordinasi lawan jenis dalam hubungan sosial karena itu makna 'awrat yang selama ini berkembang sangat ideologis.Berdasarkan itu pembacaan ulang terhadap makna tersebut sangat penting untuk membuka relasi kuasa yang ada. Salah satu cara pembacaan ulang adalah dengan merujuk ke sumber asli yakni al-Qur'an. Berdasarkan telaah terhadap beberapa ayat al-Qur'an, kata 'awrat itu tidak selalu merujuk kepada tubuh manusia tetapi juga dipergunakan untuk menggambarkan tempat dan waktu yang dianggap rawan. Dengan demikian makna 'awrat itu lebih tepatnya bermakna hal­hal yang dianggap rawan. Dalam kaitan dengan tubuh manusia adalah hal-hal yang sangat rawan untuk menimbulkan terjadinya marabahaya atau fitnah.Namun demikian, al-Qur'an tidak memberikan batasan yang pasti tentang bagian tubuh yang dianggap rawan sehingga harus ditutupi. AI-Qur'an hanya menyebutkan bahwa dalam menjalin hubungan antara laki-laki dan pmmpuan perlu dijagi nilai-nilai kesopanan, moralitas dan kesucian. Tidak ada batasan tertentu yang mesti dipatuhi. Hal nampaknya disesuai dengan situai dan kondisi yang ada.
PERAN LEKTUR KEAGAMAAN DALAM PEMBERDAYAAN PENDIDIKAN AGAMA ISLAM
Authors: Muslihah Eneng
Published: February 2019

Dalam KBBI bahan bacaan disebut dengan nama lektur. Islam memandangpenting arti membaca, hal ini jelas tercermin pada wahyu pertama Allah yang diawali dengan kata Iqra atau Bacalah. Kata ini mengandung makna dimulai dari membaca fenomena alam sampai membaca materi tertulis.Dalam tulisan ini, penulis hanya akan menekankan pada aspek bahan bacaan saja, karena bahan bacaan berkaitan erat dengan pembaca dan aktivitas membaca yang dilakukannya. Bahkan secara lebih spesifik terfokus pada bahan bacaan (lektur) keagamaan baik klasik maupun modern dan peran yang dimainkannya dalam pemberdayaan pendidikan Islam secara selayangpandang.
Verification of a method for determining the limit pressure peak in a mechanical continuously variable transmission
Authors: Radzymiński Bratosz , Goszczak Jaroslaw
Published: February 2019

This research concerns the continuously variable transmission that is to be used in a hybrid drivetrain with a mechanical energy accumulator as a secondary energy source. The purpose of this research is to verify the method of determining the pressure surge which ensures a fast but safe ratio change, from the perspective of the belt slip point of a continuously variable transmission.
The obtained results allowed to decide on the design of a more extensive test bench enabling simulation of the load of a continuously variable transmission resulting from the acceleration and braking of the car's mass. In addition, the test results confirmed the possibility of regulating the pressures in two actuators to change the ratio and increase the speed of this change.
Los docentes de ciencias naturales y el “Programa Conectar Igualdad” en la ciudad de Córdoba (Argentina)
Authors: Occelli Maricel , Garcia Romano Leticia
Published: February 2019

A partir del “Programa Conectar Igualdad” nos propusimos indagar cómo los docentes de ciencias naturales utilizan las TIC en su vida cotidiana; cuáles son sus percepciones acerca de la presencia de las netbooks en las aulas; cómo las utilizan en sus prácticas educativas y cuáles son sus expectativas. Para ello, implementamos diferentes estrategias de indagación las cuales incluyeron dos cuestionarios y entrevistas realizadas a docentes de escuelas secundarias de la ciudad de Córdoba (Argentina). En función de los resultados obtenidos, encontramos que los docentes integran las TIC en sus vidas cotidianas. Los profesores advierten que la presencia de estas tecnologías en el aula genera situaciones problemáticas pero también las identifican como herramientas positivas que abren nuevas oportunidades. En sus prácticas, si bien la mayoría de los docentes realiza una integración débil de las tecnologías, también se registran prácticas tendientes a una integración intensiva que permitirían “pensar-con” la tecnología.
Menjaga Kesehatan Mental Perspektif Al-Qur’an dan Hadits
Authors: Fuad Ikhwan
Published: February 2019

This article elaborates on theories of psychology in the Qur'an and Sunnah on how to maintain mental health. As the basic source of Islam, the Qur'an and the Hadith contains much information and knowledge, including mental health problems amid concern the world of psychology today. With the approach of Normative-theological author tried to dig texts that discuss these topics and explain its theories. The author came to the conclusion that 1) maintaining of mental health in Qur'an and Sunnah perspective based on the notion wasathiyah (moderation) in fulfilling the needs of the material and the spiritual, 2) method of the Qur'an and Hadith in realizing mental health, among others by strengthening the spiritual dimension, control of biological motivations and methods learned are necessary for mental health. Achievement of these methods can be seen from the life of the prophet and the sahabata of the relationship with God, with himself, his relationships with others, and the universe.
Aktualisasi Transgender di Kabupaten Jombang
Authors: Palupi Soenjoto Wening Purbatin
Published: February 2019

Transgender phenomena in the community get a variety of reactions. Many cases have sprung up that need to be addressed. In this study focused on the opinions and forms of social action carried out by a student against transgender existence. To answer the researchers used the theory of social action, Max Weber. Snowball is a technique used to determine the informant with the help to the informant. This research was conducted by means of qualitative description and choose a location in the area of Jombang, East Java. Data collected by means of in-depth interviews were then analyzed inductively. Based on the results of the study, presented on the causes being a transgender. Researchers found a uniform answer as to the cause of both informants about being transgender subjectively. It can be seen that transgender is a person were has a biological disorder for example born with two genitals and some were caused by some external factors as the influence of the social environment. In addition there are internal factors that have an instinct that is different from the original gender.
Rehabilitasi Neuropsikologi Dalam Upaya Memperbaiki Defisit Executive Function (Fungsi Eksekutif) Klien Gangguan Mental
Authors: Fatwikiningsih Nur
Published: February 2019

Executive function is responsible for directing self behavior in order to purposive and aims such as planning, organizing, problem solving, self-monitoring skills and self regulation. This function is associated with frontal lobe (center of think). The main components of executive function are anticipation (set realistic expectations, understanding the consequences), planning (organization), execution or implementation (maintain flexibility), self-monitoring (emotional control, error recognition). Dysfunction executive (deficit of executive functions) is one cause of disability in the client's mental disorders so that clients of mental disorders commonly have difficulty in performing  activities of complex psychological like behavior of complex, purposeful, targeted and selective attention, decision-making, judgment, selection, planning, and flexibility. Neuropsychological rehabilitation efforts can be used to improve executive function (executive function) thus will significantly improve emotional health, social functioning, and independent skill.  The rehabilitation program consists of a variety of techniques that include Cognitive Adaptation Training (CAT), verbalization, goal setting and cognitive remediation.
NUTRITIONAL EVALUATION AND PROCESSING OF OYSTER MUSHROOM, PLEUROTUS SAJOR
Authors: GOUR SHASHI , GOUR A.K. , SONI NITIN
Published: February 2019

Nutritional points of view, P.sajor had high content of all the proximate principles like protein, fat, carbohydrates, ash and fibre in as compared to P.florida and P. sapidus in both fresh or dry weight basis. The drying process for extension of shelf-life indicates that hot air oven drying method took less time (4hrs) in comparison to sun drying method (12hrs). The weight loss was, more rapid in hot air drying method. Before drying of mushroom, 0.5% kms treatment with blanching was essential for controlling the browning reaction of the product. Better rehydration ratio was observed in sundried mushroom than the hot air oven dried mushrooms. Blanching of mushroom carried out during drying also reduced the rehydration ratio in both the processes.
Application of adult mesenchymal stem cells in bone and vascular tissue engineering
Authors: Trávníčková Martina , Bačáková Lucie
Published: February 2019

Tissue engineering is a very promising field of regenerative medicine. Life expectancy has been increasing, and tissue replacement is increasingly needed in patients suffering from various degenerative disorders of the organs. The use of adult mesenchymal stem cells (e.g. from adipose tissue or from bone marrow) in tissue engineering seems to be a promising approach for tissue replacements. Clinical applications can make direct use of the large secretome of these cells, which can have a positive influence on other cells around. Another advantage of adult mesenchymal stem cells is the possibility to differentiate them into various mature cells via appropriate culture conditions (i.e. medium composition, biomaterial properties, and dynamic conditions). This review is focused on current and future ways to carry out tissue replacement of damaged bones and blood vessels, especially with the use of suitable adult mesenchymal stem cells as a potential source of differentiated mature cells that can later be used for tissue replacement. The advantages and disadvantages of different stem cell sources are discussed, with a main focus on adipose-derived stem cells. Patient factors that can influence later clinical applications are taken into account.
Evaluation of Resistant Starch Quality from Different Types of Banana in Batter Coating Formulation to Reduce Oil Absorption in Fried Food
Authors: Della Karissha Fritzi , Pratiwi Mutiara , Cahyana Purwa Tri , Gunawan-Puteri Maria DPT
Published: February 2019

Fried food is convenient for many people due to its pleasant texture and taste. On the other hand, it comes with the risk of high oil absorption which might lead to certain health problems. Resistant starch (RS) has been known to have a functionality of reducing oil absorption. Three different types of banana: Kepok (Musa paradisiaca formatypica), Raja Bulu (Musa paradisiaca L.) and Ambon (Musa paradisiaca L. var sapientum) were evaluated on its performance when utilized as source of resistant starch especially on their application in reducing oil absorption in fried food. Tempeh was used as the food model. Banana starch (RS2) was isolated through water alkaline extraction process, continued with modification process through three repeated cycles of autoclaving-cooling process to obtain the RS3. RS3 was added into the batter coating formulation at three substitution ratios (10%, 30% and 50%) and then used to coat tempeh before frying. Evaluation of resistant starch in batter and battered productwas conducted on the following parameters: fat content, water retention capacity (WRC), coating pick up and sensory analysis. The result of this study revealed that Raja Bulu showed the most effective result on reducing oil absorption in the food tested. In the three bananas used, the ratio of 50% performed best in coating pick up (highest), WRC (highest) and fat content(lowest) parameters, but not significantly different with the 30% ratio. In terms of sensory acceptance, using Raja Bulu as the selected banana type, 30% of substitution ratio was significantly more preferable by the panelists in crispness, oiliness, and overall acceptance attributes compared to control and other substitution ratios.
Experiment of Multispectral Sensing Sensor for Urban Road Materials in Outdoor Environment
Authors: Darmawan Matthew Rio , Ipung Heru Purnomo , Galinium Maulahikmah
Published: February 2019

This research is the first attempt to conduct several experiments of multispectralsensing sensor for urban road materials in outdoor environment. This research aims to classifyfive urban road materials that are aggregates, asphalts, concrete, clay, natural fibre includingvegetation and water. There were 9 cameras in the multispectral sensing sensor. Seven cameraattached with narrow band optical filter with the centre spectrum at 710nm, 730nm, 750nm,800nm, 870nm, 905nm and 950nm. One camera attached with 720 nm normalization band useshigh pass optical filter. Another camera attached with UV/IR cut optical filter works as a RGBcamera. The images results, that have been taken, are processed in MATLAB to get the imagingindex results from the multispectral system. Naïve Bayes classifier is used in Weka to classifythe urban road materials with vegetation and water. The first classification and testing thatclassifies five urban road materials with vegetation and water have accuracy results ranged from0 % to 32% while the accuracy results without vegetation and water have better accuracy resultsranged from 0 % to 55 %.
The Effect of a Restaurant’s Physical Environment on Customer Repurchase Behaviour: A Case Study of An Upscale Restaurant
Authors: Yip Janice , Mbouw Esa T
Published: February 2019

With the increasing number of restaurants being opened annually, restauranteurs can not only pay attention to the food and service, but also to the restaurant’s physical atmosphere. This study focuses on DINESCAPE as the theory for physical environment. It aims to find whether or not the factors of DINESCAPE affect customer repurchase behavior in an upscale restaurant. This is a quantitative descriptive research and uses questionnaires to obtain its data.132 data from questionnaires are obtained from customers that have dined at Restaurant X. Restaurant X is an upscale restaurant located in the heart of Jakarta. Multiple linear regression isused to analyze the data and obtained the result. Result shows a strong relationship of 67,9% from physical environment towards customer repurchase behavior. Each hypothesis regarding the factors of DINESCAPE are accepted and shows that each factor of DINESCAPE affect customer repurchase behavior. Based on the findings, recommendations for Restaurant X include, but not limited to, improving the restaurant facility aesthetics such as lighting and themed decorations to stimulate repurchase behaviours.
RELAs 10-year anniversary
Authors: Fejes Andreas , Fragoso António , Jütte Wolfgang , Kurantowicz Ewa , Merrill Barbara , Salling Olesen Henning , Wildemeersch Danny
Published: February 2019

The first issue of RELA was published in 2010, so with this issue we enter the 10-year anniversary. In this editorial, we will firstly elaborate on what we as editors find that RELA has accomplished. Secondly, we introduce changes that are taking place while entering 2019, and lastly, we introduce the papers which are included in this issue.
Estrogens Modulate Somatostatin Receptors Expression and Synergize With the Somatostatin Analog Pasireotide in Prostate Cells
Authors: Rossi Valentina , Di Zazzo Erika , Galasso Giovanni , De Rosa Caterina , Abbondanza Ciro , Sinisi Antonio A. , Altucci Lucia , Migliaccio Antimo , Castoria Gabriella
Published: February 2019

Prostate cancer (PC) is one of the most frequently diagnosed cancers and a leading cause of cancer-related deaths in Western society. Current PC therapies prevalently target the functions of androgen receptor (AR) and may only be effective within short time periods, beyond which the majority of PC patients progress to castration-resistant PC (CRPC) and metastatic disease. The role of estradiol/estradiol receptor (ER) axis in prostate transformation and PC progression is well established. Further, considerable efforts have been made to investigate the mechanism by which somatostatin (SST) and somatostatin receptors (SSTRs) influence PC growth and progression. A number of therapeutic strategies, such as the combination of SST analogs with other drugs, show, indeed, strong promise. However, the effect of the combined treatment of SST analogs and estradiol on proliferation, epithelial mesenchyme transition (EMT) and migration of normal- and cancer-derived prostate cells has not been investigated so far. We now report that estradiol plays anti-proliferative and pro-apoptotic effect in non-transformed EPN prostate cells, which express both ERα and ERβ. A weak apoptotic effect is observed in transformed CPEC cells that only express low levels of ERβ. Estradiol increases, mainly through ERα activation, the expression of SSTRs in EPN, but not CPEC cells. As such, the hormone enhances the anti-proliferative effect of the SST analog, pasireotide in EPN, but not CPEC cells. Estradiol does not induce EMT and the motility of EPN cells, while it promotes EMT and migration of CPEC cells. Addition of pasireotide does not significantly modify these responses. Altogether, our results suggest that pasireotide may be used, alone or in combination with other drugs, to limit the growth of prostate proliferative diseases, provided that both ER isoforms (α and β) are present. Further investigations are needed to better define the cross talk between estrogens and SSTRs as well as its role in PC.
Haplotype and Haplotype-Environment Interaction Analysis Revealed Roles of SPRY2 for NSCL/P among Chinese Populations
Authors: Zhou Ren , Wang Mengying , Li Wenyong , Wang Siyue , Zheng Hongchen , Zhou Zhibo , Hu Yonghua , Li Jing , Wu Tao , Zhu Hongping , Beaty Terri H.
Published: February 2019

Non-syndromic cleft lip with or without cleft palate (NSCL/P) is one of common birth defects in China, with genetic and environmental components contributing to the etiology. Genome wide association studies (GWASs) have identified SPRY1 and SPRY2 to be associated with NSCL/P among Chinese populations. This study aimed to further explore potential genetic effect and gene—environment interaction among SPRY genes based on haplotype analysis, using 806 Chinese case—parent NSCL/P trios drawn from an international consortium which conducted a genome-wide association study. After the process of quality control, 190 single nucleotide polymorphisms (SNPs) of SPRY genes were included for analyses. Haplotype and haplotype—environment interaction analyses were conducted in Population-Based Association Test (PBAT) software. A 2-SNP haplotype and three 3-SNP haplotypes showed a significant association with the risk of NSCL/P after Bonferroni correction (corrected significance level = 2.6 × 10−4). Moreover, haplotype—environment interaction analysis identified these haplotypes respectively showing statistically significant interactions with maternal multivitamin supplementation or maternal environmental tobacco smoke. This study showed SPRY2 to be associated with NSCL/P among the Chinese population through not only gene effects, but also a gene—environment interaction, highlighting the importance of considering environmental exposures in the genetic etiological study of NSCL/P.
Design of a Thorium Metal Target for 225Ac Production at TRIUMF
Authors: Robertson Andrew K.H. , Lobbezoo Andrew , Moskven Louis , Schaffer Paul , Hoehr Cornelia
Published: February 2019

With recent impressive clinical results of targeted alpha therapy using 225Ac, significant effort has been directed towards providing a reliable and sufficient supply of 225Ac to enable widespread using of 225Ac-radiopharmaceuticals. TRIUMF has begun production of 225Ac via spallation of thorium metal with 480 MeV protons. As part of this program, a new 225Ac-production target system capable of withstanding the power deposited by the proton beam was designed and its performance simulated over a range of potential operating parameters. Special attention was given to heat transfer and stresses within the target components. The target was successfully tested in two irradiations with a 72–73 µA proton beam for a duration of 36.5 h. The decay corrected activity at end of irradiation (average ± standard deviation) was (524 ± 21) MBq (14.2 mCi) and (86 ± 13) MBq (2.3 mCi) for 225Ac and 225Ra, respectively. These correspond to saturation yields of 72.5 MBq/µA for 225Ac and 17.6 MBq/µA for 225Ra. Longer irradiations and production scale-up are planned in the future.
Post-Impact Behaviour of Pseudo-Ductile Thin-Ply Angle-Ply Hybrid Composites
Authors: Prato Alessia , Longana Marco L. , Hussain Ambreen , Wisnom Michael R.
Published: February 2019

This work experimentally explores the post-impact behaviour of thin-ply angle-ply pseudo-ductile carbon fibre laminates subjected to tensile load. Indentation and low-speed impact tests were performed on standard tensile test specimens. Non-destructive tests were used to investigate the damage propagation. Digital Image Correlation (DIC) was adopted to detect the strain distribution during tensile tests. Post-damage pseudo-ductile behaviour was retained in angle-ply hybrid composites subjected to tensile loading conditions.
Systematic Degradation Rate Analysis of Surface-Functionalized Porous Silicon Nanoparticles
Authors: Kang Rae Hyung , Lee Seo Hyeon , Kang Sangrim , Kang Jinyoung , Hur Junho K. , Kim Dokyoung
Published: February 2019

Porous silicon nanoparticles (pSiNPs) have been utilized within a wide spectrum of biological studies, as well as in chemistry, chemical biology, and biomedical fields. Recently, pSiNPs have been constantly coming under the spotlight, mostly in biomedical applications, due to their advantages, such as controlled-release drug delivery in vivo by hydrolysis-induced degradation, self-reporting property through long life-time photoluminescence, high loading efficiency of substrate into pore, and the homing to specific cells/organ/bacteria by surface functionalization. However, the systematic degradation rate analysis of surface-functionalized pSiNPs in different biological media has not been conducted yet. In this paper, we prepared four different surface-functionalized pSiNPs samples and analyzed the degradation rate in six different media (DI H2O (deionized water), PBS (phosphate-buffered saline), HS (human serum), DMEM (Dulbecco’s modified Eagle’s medium), LB (lysogeny broth), and BHI (brain heart infusion)). The obtained results will now contribute to understanding the correlation between surface functionalization in the pSiNPs and the degradation rate in different biological media. The characterized data with the author’s suggestions will provide useful insights in designing the new pSiNPs formulation for biomedical applications.
Incorporation of Phosphorus Impurities in a Silicon Nanowire Transistor with a Diameter of 5 nm
Authors: Jiang Yanfeng , Wang Wenjie , Wang Zirui , Wang Jian-Ping
Published: February 2019

Silicon nanowire (SiNW) is always accompanied by severe impurity segregation and inhomogeneous distribution, which deteriorates the SiNWs electrical characteristics. In this paper, a method for phosphorus doping incorporation in SiNW was proposed using plasma. It showed that this method had a positive effect on the doping concentration of the wires with a diameter ranging from 5 nm to 20 nm. Moreover, an SiNW transistor was assembled based on the nanowire with a 5 nm diameter. The device’s ION/IOFF ratio reached 104. The proposed incorporation method could be helpful to improve the effect of the dopants in the silicon nanowire at a nanometer scale.
Disaster-Recovery Social Capital and Community Participation in Earthquake-Stricken Ya’an Areas
Authors: Li Zhichao , Tan Xihan
Published: February 2019

Social capital plays a significant role in post-disaster community participation and disaster recovery. This study divides social capital into three aspects: Cognition, structure, and relation, and discusses the impact of these factors on community participation in post-disaster recovery. Through data analysis, we found that a self-organized relationship villager network had a positive effect on villagers’ participation in voluntary community activities after an earthquake, while the local cadre relationship network had a negative impact. However, the latter could encourage villagers to participate in disaster-recovery activities organized by the local government. These findings indicate that the mobilization mechanism for post-disaster local-government reconstruction and community self-organization are the same, both coming through the social-acquaintance network, a type of noninstitutionalized social capital. The implication of this study suggests that local government should attach much importance to the construction and integration of social networks in earthquake-stricken areas to cultivate community social capital.
Hsa_circ_0003998 Promotes Chemoresistance via Modulation of miR-326 in Lung Adenocarcinoma Cells
Authors: Yu Wanjun , Peng Weidong , Sha Hanyun , Li Jipeng
Published: February 2019

Circular RNAs (circRNAs) represent a new class of noncoding RNAs that is involved in the development of cancer. However, little is known about their role in chemoresistance. In the present study, we found that hsa_circ_0003998 expression levels in lung adenocarcinoma (LAD) tissues and
docetaxel-resistant cell lines (A549/DTX and H1299/DTX) were upregulated. Knockdown of hsa_circ_0003998 decreased chemoresistance, inhibited proliferation, and enhanced apoptosis in docetaxel-resistant LAD cells. Moreover, by using bioinformatics and luciferase reporter assays, we found that
miR-326 was a direct target of hsa_circ_0003998. Functional analysis revealed that miR-326 mediated the effect of hsa_circ_0003998 on chemosensitivity. Our findings provide a molecular insight on understanding drug resistance in LAD cells. Therefore, inactivation of hsa_circ_0003998 or activation
of miR-326 could be a novel approach for the treatment of LAD.
Pulmonary Embolism Masquerading as Severe Pneumonia: A Case Report
Authors: Payus Alvin Oliver , Rajah Rathika , Febriany Dayang Corieza , Mustafa Norlaila
Published: February 2019

BACKGROUND: De novo pulmonary embolism (DNPE) is a term used when pulmonary embolism (PE) occur in the absence of deep vein thrombosis (DVT). Most DNPE cases occur in a patient who had a recent injury to the chest.
CASE PRESENTATION: However, here we report a case of DNPE with a slightly different presentation where there is no preceding trauma and has symptoms that mimic severe pneumonia. He presented with high fever, dyspnoea and pleuritic chest pain. Despite on 10 L of oxygen supplementation via high flow mask and already given bolus intravenous antibiotic, the patient still tachypnoeic and was persistently in type I respiratory failure. His chest X-ray showed consolidative changes. Upon further investigation revealed no evidence of DVT on Doppler ultrasound and normal D-dimer level. Due to the high index of suspicion by the attending physician, PE was suspected and later confirmed with computed tomography pulmonary angiography scan. He was successfully treated with anticoagulation therapy. The objective of this case report is to share the difficult experience of diagnosing PE when the presentation highly atypical and mimics severe pneumonia.
CONCLUSION: And with such a masquerading presentation, one can easily miss the diagnosis. To the best of our knowledge, there are very few similar cases reported.
Structural Changes over a Short Period Are Associated with Functional Assessments in Rheumatoid Arthritis
Authors: Shimizu Tomohiro , Cruz Ana , Tanaka Matthew , Mamoto Kenji , Pedoia Valentina , Burghardt Andrew J. , Heilmeier Ursula , Link Thomas M. , Graf Jonathan , Imboden John B. , Li Xiaojuan
Published: February 2019

Objective.

To investigate the correlation between changes in radiological quantitative assessment with changes in clinical and functional assessment from baseline to 3 months in patients with rheumatoid arthritis (RA).

Methods.

Twenty-eight patients with RA [methotrexate (MTX) and anti-tumor necrosis factor–α (TNF-α) group with high disease activity (n = 18); and MTX group with low disease activity (n = 10)] underwent assessments at baseline and 3 months: clinical [28-joint count Disease Activity Score (DAS28)], functional [Health Assessment Questionnaire (HAQ) and Michigan Hand Outcome Questionnaire (MHQ)], and imaging-based [3 Tesla magnetic resonance imaging (MRI) and high-resolution peripheral quantitative computed tomography (HR-pQCT)]. MR images were evaluated semiquantitatively [RA MRI scoring (RAMRIS)] and quantitatively for the volume of synovitis and bone marrow edema (BME) lesions. Erosion volumes were measured using HR-pQCT.

Results.

After 3 months, the anti-TNF-α group demonstrated an improvement in disease activity through DAS28, HAQ, and MHQ. MRI showed significant decreases in synovitis and BME volume for the anti-TNF-α group, and significant increases in the MTX group. HR-pQCT showed significant decreases in bone erosion volume for the anti-TNF-α group, and significant increases in the MTX group. No significance was observed using RAMRIS. Changes in synovitis, BME, and erosion volumes, but not RAMRIS, were significantly correlated with changes in DAS28, HAQ, and MHQ.

Conclusion.

Quantitative measures were more sensitive than semiquantitative grading when evaluating structural and inflammatory changes with treatment, and were associated with patient clinical and functional outcomes. Multimodality imaging with 3T MRI and HR-pQCT may provide promising biomarkers that help determine disease progression and therapy response.
Validity and Responsiveness of Combined Inflammation and Combined Joint Damage Scores Based on the OMERACT Rheumatoid Arthritis MRI Scoring System (RAMRIS)
Authors: Sundin Ulf , Østergaard Mikkel , Glinatsi Daniel , Aga Anna-Birgitte , Hørslev-Petersen Kim , Hetland Merete L. , Stengard-Pedersen Kristian , Junker Peter , Ejbjerg Bo J. , Bird Paul , Conaghan Philip G. , Lillegraven Siri , Haavardsholm Espen A.
Published: February 2019

Objective.

The RAMRIS [Outcome Measures in Rheumatology rheumatoid arthritis (RA) magnetic resonance imaging (MRI) Scoring system] is used in clinical RA trials. We have investigated methods to combine the RAMRIS features into valid and responsive scores for inflammation and joint damage.

Methods.

We used data from 3 large randomized early RA trials to assess 5 methods to develop a combined score for inflammation based on RAMRIS bone marrow edema, synovitis, and tenosynovitis scores, and a combined joint damage score based on erosions and joint space narrowing. Methods included unweighted summation, normalized summation, and 3 different variants of weighted summation of the RAMRIS features. We used a derivation cohort to calculate summation weights to maximize the responsiveness of the combined score. Construct validity of the combined scores was examined by assessing correlations to imaging, clinical, and biochemical measures. Responsiveness was tested by calculating the standardized response mean (SRM) and the relative efficiency of each score in a validation cohort.

Results.

Patient characteristics, as well as baseline and followup RAMRIS scores, were comparable between cohorts. All combined scores were significantly correlated to other imaging, clinical, and biochemical measures. Inflammation scores combined by normalized and weighted summation had significantly higher responsiveness in comparison to unweighted summation, with SRM (95% CI) for unweighted summation 0.62 (0.51–0.73), normalized summation 0.73 (0.63–0.83), and weighted summation 0.74 (0.64–0.84). For the damage score, there was a trend toward higher responsiveness for weighted summation.

Conclusion.

Combined MRI scores calculated by normalized or weighted summation of individual MRI pathologies were valid and responsive.
Development and Validation of an OMERACT MRI Whole-Body Score for Inflammation in Peripheral Joints and Entheses in Inflammatory Arthritis (MRI-WIPE)
Authors: Krabbe Simon , Eshed Iris , Gandjbakhch Frédérique , Pedersen Susanne J. , Bird Paul , Mathew Ashish J. , Lambert Robert G. , Maksymowych Walter P. , Glinatsi Daniel , Stoenoiu Maria S. , Poggenborg René , Jans Lennart , Jaremko Jacob L. , Herregods Nele , Foltz Violaine , Conaghan Philip G. , Althoff Christian E. , Paschke Joel , Peterfy Charles , Hermann Kay-Geert A. , Østergaard Mikkel
Published: February 2019

Objective.

To develop a whole-body magnetic resonance imaging (MRI) scoring system for peripheral arthritis and enthesitis.

Methods.

After consensus on definitions/locations of MRI pathologies, 4 multireader exercises were performed. Eighty-three joints were scored 0–3 separately for synovitis and osteitis, and 33 entheses 0–3 separately for soft tissue inflammation and osteitis.

Results.

In the last exercise, reliability was moderate-good for musculoskeletal radiologists and rheumatologists with previously demonstrated good scoring proficiency. Median pairwise single-measure/average-measure ICC were 0.67/0.80 for status scores and 0.69/0.82 for change scores; κ ranged 0.35–0.77.

Conclusion.

Whole-body MRI scoring of peripheral arthritis and enthesitis is reliable, which encourages further testing and refinement in clinical trials.