bluuebunny/crossref_metadata_2025 huggingface dataset:
OPERATOR'S SPATIAL ORIENTATION ABILITY DURING CONTROL OF REMOTELY-PILOTED AIRCRAFT IN VIRTUAL REALITY
Authors:   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Bubeev Yu. , Usov V. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Kryuchkov B.I. ,   Gagarin Research and Test Cosmonaut Training Center, Star City, Moscow region, Syrkin L.D. ,   State Socio-Pedagogical University, Kolomna, Moscow region, Mikhaylyuk M. ,   Russian Federation State Research Center – Scientific Research Institute for System Analysis of the Russian Academy of Sciences, Moscow
Published: June 2021

Functioning of remotely-piloted aircraft (RPA) in extreme poorly structured environments often calls for immediate intervention in order to prevent collision with an artificial or natural object. Assessment of human reliability in complicated situations needs profession-relevant tests of spatial orientation particularly important for operators of unpiloted apparatuses. The immersive virtual environment dominates in development of remote control technologies. The paper analyzes approaches used in cognitive sciences to explore imagination of 2D and 3D virtual scenes and thus to get insight into the psychological aspects of spatial orientation. Psychological models can be employed in selection and setting work regulations for RPA operators.
STROME-DEPENDENT EXPANSION OF HEMOPOIETIC PRECURSORS DURING 7-DAY MODELING OF THE EFFECTS OF MICROGRAVITY
Authors:   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Tyrina (Golikova) Е.А. , Bobyleva P.I. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Andreeva E.R. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Buravkova L.B. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow
Published: June 2021

It is well known that long-term space missions influence various myeloid shoots of hemopoiesis in humans and animals. In this investigation, we used several optimized models of co-culturing mesenchymal stromal cells (MSCs) and hemopoietic stem and progenitor cells (HSPCs) to analyze the HSPCs suspension fractions following 7-day modeling of the effects of microgravity. We determined the number of developing HSPCs, presence of colony-forming units (CFU) of various hemopoietic shoots and phenotype spectrum of cells in colonies. We observed an increased number of HSPCs, decreased number of CFUs, and changes in the structure of CFU population after the exposure to modeled microgravity.
SOME ASPECTS OF THE RADIATION EXPOSURE OF COSMONAUTS TRAVERSING THE EARTH'S MAGNETOSPHERE
Authors:   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Mitrikas V.G.
Published: June 2021

Dose loading of cosmonaut's representative body organs beyond the Earth's magnetosphere was calculated for various scenarios of departure from a reference orbit in space vehicles of different design. Calculation of contribution to the equivalent doses from protons and electrons of Earth's radiations belts and galactic cosmic rays (GCR) demonstrated that, irrespective of vehicle design, during solar minimum and growing activity the equivalent dose does not exceed the established limit for a single exposure to 150 mSv. However, radiation exposure may vary in times depending on the traverse trajectory.
ENDURANCE OF HYPOXIC HYPOXIA AFTER PRELIMINARY BREATHING OF NORMOXIC MIXTURES CONTAINING ARGON OR KRYPTON
Authors:   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Soldatov P.E. , Shulaguin Yu.A. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Tyurin-Kuzmin А.Yu. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Dyachenko A.I. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow
Published: June 2021

The purpose was assessment of the possibility to increase mammal's endurance of hypoxic hypoxia by preconditioning through breathing normoxic gas mixtures (BGM) containing argon or krypton. Preconditioning by krypton-containing BGM one or two hours prior to hypoxia (initial О2 concentration of 20.8 %) increased endurance of oxygen starvation. Preconditioning by argon-containing BGM did not bring this effect. Immediately after hypoxia several animals in both the test and control groups displayed a short-time generalized tremor that grew in the nitrogen – argon – krypton (N2 – Ar – Kr) succession consistently with their narcotic activities. This effect can be ascribed to modification by Ar and Kr of the humoral and neuronal tremor reactions to the hypoxic stress. Testing the preconditioning effect of Kr-containing BGM prior to hypoxia with the initial О2 concentration of 14.6 ± 0.40 % also demonstrated a decrease of minimal endurable О2 concentration although less evident. Effects from normoxic Kr-containing BGM correlates with the time space between preconditioning and hypoxia.
INTERNATIONAL SYMPOSIUM «HUMAN IN SPACE» TO THE ANNIVERSARY OF THE FIRST HUMAN SPACEFLIGHT
Authors:   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Orlov O.I. , Fomina E.V. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Ponomarev S.A. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Kussmaul A.R. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Belakovskiy M.S. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow
Published: June 2021

The 23rd International «Human in Space» Symposium, dedicated to the 60th anniversary of the first human flight into space, was organized jointly on the initiative and with the organizational support of the IBMP RAS by the International Academy of Astronautics and the State Space Corporation «ROSCOSMOS», with the participation of the Ministry of Science and Higher Education of the Russian Federation and the Russian Academy of Sciences. The Symposium was held in Moscow from April 5 to April 8, 2021 in a hybrid format – more than 160 participants were present in the halls in person, and about 400 delegates connected online. On the basis of the Zoom Webinar platform, a single online resource was created with access to a personal account, allowing to participate in plenary and parallel breakout sessions. In five days, 8 plenary sessions were held (27 plenary reports were presented), four round tables were conducted on topical issues of space exploration, and 25 sessions on various aspects of space medicine and biology were held. In total, there were more than 240 oral reports and about 50 short reports (from 23 countries, including Russia, the United States, Germany, France, Belgium, China, etc.). The Institute has gained new experience in organizing events in such format, which provides a unique opportunity to expand contacts and network of interaction between specialists from different branches of science and technology around the world in the interests of further development of space biology and medicine. Such interaction serves as a necessary basis for the preparation and implementation of further steps for deep space exploration.
Coronary bifurcation lesions: current techniques for endovascular treatment
Authors: Eraliev T. K. , Khelimskii D. A. , Badoian A. G. , Krestyaninov O. V.
Published: June 2021

Bifurcation lesions are among the most challenging issues in interventional cardiology, occurring in approximately 15% – 20% of all types of coronary artery disease. Challenges in the endovascular treatment of such lesions include anatomical variability, different treatment approaches, difficulties in physiological assessment of the bifurcation branches, and a high risk of restenosis. Current bifurcation classifications are unable to prognose long-term clinical outcomes. Provisional T-stenting can be used in most cases, including in complex bifurcation lesions.  This article aimed to review the current classification of bifurcation lesions, describe the available bifurcation stenting techniques, and discuss the current evidence base.

Received 27 December 2020. Revised 9 March 2021. Accepted 12 March 2021.

Funding: The study did not have sponsorship.

Conflict of interest: Authors declare no conflict of interest.
Case report: Implantation of a personal aortic corset to stabilize the size of the root and the ascending aorta in a patient with Marfan syndrome
Authors: Nesmachnyy A.S. , Chernyavskiy A.M. , Kareva Yu.E.
Published: June 2021

Herein, we report a case of a patient with Marfan syndrome for whom we successfully stabilized the root and the ascending aorta to prevent further expansion and reduce the aortic rupture risk. For stabilization, a personal aortic corset was used, cut, and formed as per the individual anatomical parameters of the patient (external dimensions of the root and the ascending aorta). Using a personalized approach, we could create a stabilizing aortic framework that matched the anatomical dimensions of the root and the ascending aorta of the patient. Implantation of a personal aortic corset with borderline dimensions of the root and the ascending aorta enabled us to prevent major surgical trauma, artificial circulation, and postoperative anticoagulant therapy as well as lower the risk of further expansion and aorta rupture in our patient, who was predisposed to these events. Postoperative results 1 year later showed the absence of negative dynamics regarding an increase in the size of the root and the ascending aorta or hemodynamic disorders in the aortic valve of our patient with Marfan syndrome.Received 29 January 2021. Revised 15 March 2021. Accepted 16 March 2021.Funding: The study did not have sponsorship.Conflict of interest: Authors declare no conflict of interest.
Política da Reserva de Desenvolvimento Sustentável (RDS) do Tupé, no Amazonas, e as educações no contexto Amazônico
Authors: Borges Heloísa da Silva , Silva Carlos Augusto da , Muller Riulma Ventura
Published: June 2021

O artigo apresenta uma parte da pesquisa realizada no Curso de Mestrado do Programa de Pós-Graduação em Educação da UFAM, no período de 2017 a 2019, intitulada Políticas Públicas e Educação do Campo no Contexto Amazônico: Estudo na RDS do Tupé, na Comunidade de São João – Manaus/AM. Por ser fruto dessa pesquisa, este artigo recebeu o título Política da Reserva de Desenvolvimento Sustentável (RDS) do Tupé, no Amazonas, e as Educações no Contexto Amazônico, uma vez que faz referência a um dos objetivos específicos do estudo, que é examinar os documentos de criação dessa RDS e suas políticas públicas para educação. Os procedimentos metodológicos se basearam em estudos bibliográficos de vários autores: Brandão (2013), Caldart (2015), Freire (2003), Gohn (2020), Silva (2017), Muller (2019), Pinto (2010), Borges (2015). Também foram analisados os seguintes documentos: Constituição Federal de 1988; LDB n.º 9.394/96; Lei n.º 3.173, de 6 de junho de 1957; Decreto-Lei n.º 288, de 1967; Decreto 8.044/2005, de criação da RDS/SEMMA (04/11/2020); Plano de Gestão (2016). Ao longo do estudo foi possível constar que, nessa RDS, existem três educações: a não formal, a formal e a informal. Os dados obtidos revelam que, apesar da conquista de legislações que tratam das políticas públicas que atendam às comunidades ribeirinhas, no que se refere à educação formal, sobretudo à Educação Básica, a Comunidade de São João do Tupé ainda é atendida apenas por políticas paliativas.
Políticas de educação do campo no território de identidade sertão produtivo na Bahia-Brasil: apontamentos de pesquisa
Authors: Marques Tatyanne Gomes , Pereira Eugênia da Silva , Silva Priscila Teixeira da
Published: June 2021

Este texto tem por objetivo apresentar e analisar as políticas de Educação do Campo no microcontexto do Território de Identidade Sertão Produtivo na Bahia – Brasil. O estudo se situa no campo das políticas públicas educacionais e centra-se nas propostas implementadas e/ou reivindicadas por diferentes atores e atrizes que protagonizam a vida e atuam no microcontexto focalizado. Para isso, faz uso de uma metodologia de revisão bibliográfica das produções de 2009 a 2020 da linha de pesquisa “Educação do Campo, Educação de Jovens e Adultos e Movimentos Sociais”, do Núcleo de Estudo, Pesquisa e Extensão Educacional Paulo Freire (NEPE), da Universidade do Estado da Bahia (UNEB), que tem o Sertão Produtivo como lócus principais de suas investigações. O levantamento das produções evidencia uma produção diversa – teses, dissertações, Trabalho de Conclusão de Curso, artigos em periódicos e anais de eventos. A análise dessas produções confirma, no cenário local, as contradições da política pública para a Educação do Campo: uma crescente visibilização dessa modalidade educacional e seus/suas protagonistas; a inserção dessa pauta nos marcos legais e nas políticas municipais, ao mesmo tempo que ocorre o fechamento e a nucleação extracampo das escolas, políticas de formação e trabalho docente universalistas, bem como práticas pedagógicas que, enquanto escolhas políticas, negam a identidade e cultura dos povos do campo.
Emerging Role of Wnt/Beta-Catenin Signalling Pathways in Cancer Progression and Role of Small Molecule Tankyrase Inhibitors in Combating Multistage Cancers
Authors: Khatun Babli , Kamath Venkatesh , Sathyanarayana Muddukrishna Badamane , Pai Aravinda , Gupta Ramji , Malviya Rishabha
Published: June 2021

In the present review, an attempt has been made to summarize the development of various
Tankyrase inhibitors focussing on Wnt/beta-Catenin pathways along with other cancer targets.
The last decade witnessed a plethora of research related to the role of various genetic and epigenetic
events that are responsible for the progression of multistage cancers. As a result, the discovery of
various signalling pathways responsible for the development of different types of cancers has resulted
in the development of molecularly targeted anticancer agents. Out of the many signalling pathways,
the Wnt/beta-Catenin pathways have attracted the attention of many research groups owing
to their involvement in cell proliferation, role in apoptosis induction, cellular differentiation and also
cell migration. The abnormal activation of this pathways has been documented in a variety of tumour
cells. Another crucial factor that makes this pathway attractive to the researches is its direct
involvement with poly ADP ribose polymerases. Tankyrases are poly ADP (Adenosine Diphosphate)
ribose polymerases that have the capacity to inhibit Wnt/beta-Catenin pathways and become
an attractive target for anticancer drugs.
Computed Tomography in Emergency Diagnosis and Management Considerations of Small Bowel Obstruction for Surgical vs. Non-surgical Approach
Authors: Taghavifar Saeed , Joyce Peter , Salehi Sana , Khosa Faisal , Shin Heeseop , Gholamrezanezhad Ali , Shah Samad
Published: June 2021

Background:

Small bowel obstruction (SBO) accounts for 15% of abdominal pain complaints referred to emergency departments and imposes significant financial burdens on the healthcare system. The most common symptom and sign of SBO is the absence of stool or flatus passsage and abdominal distension, respectively. Patients who do not demonstrate severe clinical or imaging findings are typically treated with conservative approaches. Patients with clinical signs of sepsis or physical findings of peritonitis are often instantly transferred to the operating room without supplementary imaging assessment. However, in cases where symptoms are non-specific or physical examination is challenging, such as in cases with loss of consciousness, the diagnosis can be complicated. This paper discusses the key findings identifiable on Computed Tomography (CT) which are vital for the emergent triage, proper treatment and appropriate decision making in patients with suspected SBO.

Method:

Narrative review of the literature.

Results:

CT plays a key role in emergent triage, proper treatment and decision making and provides high sensitivity, specificity, and accuracy in the detection of early-stage obstruction and acute intestinal vascular compromise. CT can also differentiate between various etiologies of SBO entity which is considered an important criterion in the triage of patients into surgical vs. non-surgical treatment.

Conclusion:

There Key CT findings which may suggest a need for surgical treatment include mesenteric edema, lack of the small-bowel feces, bowel wall thickening, fat stranding in the mesentery, and intraperitoneal fluid which are predictive of urgent surgical exploration.
Menstrual Disorders Related to Eating Disorders
Authors: Milano Walter , Ambrosio Paola , Carizzone Francesca , De Biasio Valeria , Foia Maria Gabriella , Saetta Biancamaria , Milano Maria Francesca , Capasso Anna
Published: June 2021

:

Eating Disorders (ED) are associated with multiple physical complications that strongly affect the
physical health of these young and fragile patients and can also cause significant mortality, the highest among
psychiatric pathologies. Among the various organic complications, albeit still little known, the gynecological
implications, up to infertility, are very widespread. Both among adolescent and adult patients, gynecological
symptoms can be very widespread and range from menstrual irregularities to amenorrhea, from vaginitis to
ovarian polycystosis, up to complications during the gestational phase and in postpartum, in addition to the possible
consequences on the unborn child. Among the most frequent and significant gynecological disorders in
women with ED, there are menstrual irregularities that may occur with oligomenorrhea or even amenorrhea.
This symptom, although no longer part of the DSM-5 diagnostic criteria for defining Anorexia Nervosa (AN),
must be considered a very relevant event in the overall evaluation of young women and adolescents with eating
disorders. Functional Hypothalamic Amenorrhea in ED patients is related to psychological distress, excessive
exercise, disordered eating, or a combination of these factors which results in suppression of the hypothalamic-
pituitary-ovarian axis, resulting in hypoestrogenism. The objective of this paper is to summarize the causes
and the mechanism underlying the menstrual disorders and to provide a better understanding of the correlation
between the reproductive system and the mechanisms that regulate food intake and eating habits. In addition,
early recognition of risk factors for eating disorders for gynecological implications can help put more accurate
assessments of patients to prevent potentially fatal complications. The importance of the involvement of specialist
gynecologists in the multidisciplinary team that has to follow patients with eating disorders is also discussed.
Digital Self-Management Support Tools in the Care Plan of Patients With Cancer: Review of Randomized Controlled Trials (Preprint)
Authors: Adriaans Danielle JM , Dierick-van Daele Angelique TM , van Bakel Marc Johannes Hubertus Maria , Nieuwenhuijzen Grard AP , Teijink Joep AW , Heesakkers Fanny FBM , van Laarhoven Hanneke WM
Published: June 2021

BACKGROUND

Digital self-management support tools (DSMSTs)—electronic devices or monitoring systems to monitor or improve health status—have become increasingly important in cancer care.

OBJECTIVE

The aim of this review is to analyze published randomized clinical trials to assess the effectiveness of DSMSTs on physical and psychosocial symptoms or other supportive care needs in adult patients with cancer.

METHODS

Five databases were searched from January 2013 to January 2020. English or Dutch language randomized controlled trials comparing DSMSTs with no intervention, usual care, alternative interventions, or a combination and including patients aged ≥18 years with pathologically proven cancer in the active treatment or survivorship phases were included. The results were summarized qualitatively.

RESULTS

A total of 19 publications describing 3 types of DSMSTs were included. Although the content, duration, and frequency of interventions varied considerably across studies, the commonly used elements included an assessment component, tailored symptom self-management support, an information section, a communication section, and a diary. Significant positive effects were observed on quality of life in 6 (out of 10) studies, on anxiety in 1 (out of 5) study and depression in 2 (out of 8) studies, on symptom distress in 5 (out of 7) studies, on physical activity in 4 (out of 6) studies, on dietary behavior in 1 (out of 4) study, and on fatigue in 2 (out of 5) studies. Moreover, significant negative effects were observed on anxiety in 1 (out of 5) study and depression in 1 (out of 8) study. Most interventions were web-based interventions; 2 studies used mobile apps, and 1 study used a game as a DSMST. The overall quality of the studies was found to be good, with 13 out of 19 studies classified as high quality.

CONCLUSIONS

This review suggests that DSMSTs have a beneficial effect on the quality of life. For effects on other patient outcomes (eg, anxiety and depression, symptom distress, physical activity, dietary behavior, and fatigue), the evidence is inconsistent and limited or no effect is suggested. Future research should focus on specific tumor types, study different types of interventions separately, and assess the effects of specific interventions at different stages of disease progression.
Psychological Impacts of the COVID-19 Pandemic Among Portuguese and Swiss Higher-Education Students: Protocol for a Mixed Methods Study (Preprint)
Authors: Querido Ana , Aissaoui Djamel , Dixe Maria Dos Anjos , Schwander-Maire Françoise , Cara-Nova Tanya , Charepe Zaida , Laranjeira Carlos
Published: June 2021

BACKGROUND

Higher-education students are particularly vulnerable to both everyday stressors and mental health problems. Public health emergencies may generate a range of unforeseen potential stressors for vulnerable individuals and communities. The current pandemic has apparently led to an increase in psychiatric symptoms among these students.

OBJECTIVE

The goal of this study is to characterize the psychological impact of the COVID-19 pandemic among Portuguese and Swiss higher-education students.

METHODS

This project will use a mixed methods sequential explanatory design in Portugal and Switzerland, with two consecutive phases. During Phase I, a quantitative study will assess the psychological responses of higher-education students during the COVID-19 pandemic. A convenience sampling method will be used for collecting information from students. The association between variables will be determined with univariable and multivariable analyses. During Phase II, qualitative data will be collected in order to understand the determinants of psychological stress and the strategies adopted by students as a result of the COVID-19 pandemic, as well as to identify their opinions and feelings about the teaching-learning process during quarantine. In this phase, participants will be selected using a maximum-variation sampling method. Data from focus group discussions will be coded and inductively analyzed using a thematic analysis approach. Finally, quantitative and qualitative results will be merged during interpretation to provide complementary perspectives.

RESULTS

This paper describes and discusses the protocol for this mixed methods study, which will be completed in December 2021. This study was formally approved by the local ethics committee (CE/IPLEIRIA/22/2020) in Portugal and authorized by the Swiss Association of Research Ethics Committees, swissethics (CER-VD-2020-02889).

CONCLUSIONS

This research can contribute to the development of teaching tools and methods that reinforce positive mental health strategies, hope, and adaptive coping among students, and to the development of a class on mental health interventions in the context of catastrophic and traumatic events. This project will also help government stakeholders as well as health and education professionals safeguard the psychological well-being of students facing an expanding COVID-19 pandemic.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/28757
A mask recognition algorithm based on improved YOLO-V4 neural network (Preprint)
Authors: Zhang Song , Wang Shaoqiang , Wang Shaoqiang
Published: June 2021

BACKGROUND

With the spread of the new crown virus, the wearing of masks as one of the effective preventive measures is getting more and more attention, and the behavior of not wearing a mask is likely to cause the spread of the virus, which is not conducive to the prevention and control of the epidemic.

OBJECTIVE

In this paper, a new neural network model is used to better recognize the facial features of people with exit masks.

METHODS

This paper proposes a mask recognition algorithm based on improved YOLO-V4 neural network that can solve this problem well. This paper integrates SE-Net and DenseNet network as the reference neural network of YOLO-V4 and introduces deformable convolution.

RESULTS

Compared with other target detection networks, the improved YOLO-V4 neural network used in this paper improves the accuracy of mask detection to a certain extent.

CONCLUSIONS

The improved YOLO-V4 network proposed in this article has verified its feasibility and accuracy through experiments and has great value in use. Improving the YOLO-V4 network can help better respond to face recognition with masks in the epidemic. However, the model studied in this article focuses on accuracy and is slightly lacking in speed. The next step is to increase its speed based on ensuring accuracy and consider actual deployment and use.
Project HALO: A Post-Market, Observational Registry of Data Derived from Serenity LiquidTM, Serenity GenomeTM, and Clinical Parameters (Preprint)
Authors: Hagen Monika , Newton Danette , Richina Jonathan , Gambon Stow Petra , Douissard Jonathan
Published: June 2021

BACKGROUND

Registries are a valuable tool for data collection and observation of medical innovations in a real-world setting. Serenity LiquidTM and Serenity GenomeTM are newly launched diagnostic platforms analyzing large genetic datasets in combination with clinical data to deliver precision preventative medicine. To this point, no systematic data is available to observe the use and clinical implementations of these platforms.

OBJECTIVE

To create a data repository collecting data from Serenity LiquidTM, Serenity GenomeTM, and clinical parameters for analyses.

METHODS

Individuals receiving Serenity LiquidTM or Serenity GenomeTM are solicited to participate in this registry. In addition to the initial dataset, a clinical update is secured every six months. Data from the registry participants are pseudo-anonymized and archived in a HIPPA-compliant research database for regular analyses.

RESULTS

Includes but is not limited to correlations between genetic and clinical data, the impact of genetic data on the clinical course of patients, comparisons between specific cohorts (within this database and against historical cohorts) on an ongoing basis.

CONCLUSIONS

This is a prospective registry collecting genetic and clinical data to gather important information, provide novel insights by continuously analyzing the data in this registry.
Reviu Sistematik Penelitian Organizational Citizenship Behavior (OCB) di Indonesia
Authors: Grasiaswaty Novika
Published: June 2021

Penelitian mengenai Organizational Citizenship Behavior (OCB) telah berkembang pesat di Barat dan merumuskan beberapa reviu literatur maupun meta-analisis yang pada akhirnya membentuk konstruk ini menjadi lebih ajek dan menentukan arah penelitian selanjutnya. Berbeda dengan penelitian OCB di Indonesia, meskipun juga populer, tetapi kajian literatur mengenainya masih belum ditemui. Kajian literatur kali ini dilakukan pada artikel yang meneliti OCB di Indonesia pada rentang sepuluh tahun terakhir (2009-2019). Didapatkan beberapa artikel dan hasil dari reviu yang menunjukkan jika penelitian OCB di Indonesia : (1) Konstruk yang digunakan terfokus pada beberapa konstruk arus utama dan pada responden kerah putih serta (2) metode penelitian sebagian besar masih menggunakan paper and pencil questionnaire dan (3) sumber data didapat dari satu sumber primer untuk dua atau lebih variabel sehingga rentan dengan common method variance. Reviu diakhiri dengan usulan untuk penelitian mengenai OCB di Indonesia ke depannya.
Identification of gene expression location of angiotensin‐converting enzyme‐2 SNPs as a receptor for SARS‐CoV‐2 in different populations by using various databases
Authors: Perwitasari Dyah Aryani , Maliza Rita , Murti Bayu Tri , Dania Haafizah , Putri Athika Darumas
Published: June 2021

The World Health Organization (WHO) has announced that Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) and Coronavirus disease (COVID‐19) is considered a worldwide pandemic. Rapidly rising numbers of patients have been reported in almost every country, along with the growing mortality rates. Uncontrolled growth in patient numbers may be due to reasons such as treatment options and vaccine availabilities and unidentified targets of SARS‐CoV‐2. Previous study has revealed that the molecular target of SARS‐CoV‐2 is analogous to SARS (2003), i.e. angiotensin‐converting enzyme‐2 (ACE‐2). Therefore, the determination of ACE‐2 may enrich existing information and facilitate development of drugs targeted toward SARS‐CoV‐2. This study aims to screen the expression of ACE‐2 genes and their relationship to the types of SNP variants in SARS‐CoV‐2. We explored a series of observations using powerful databases, e.g. GTEx portal, HaploReg, 1000 Genome and Ensembl, to identify the gene variant of ACE‐2. We showed that ACE‐2 is highly expressed in the testes and small intestine, while its lowest level is observed in lymphocytes. Subsequently, we observed 17 gene variants containing a missense mutation potentially damaging protein level. Among these genes, single nucleotide polymorphism (SNP) rs370187012 shows the highest damage‐level score, while the lowest effect is in SNP rs4646116. The highest frequency of the C allele was observed in European populations (1%). In addition to showing that ACE‐2 is expressed in several organs, we concluded that the ACE‐2 gene variation can be found in African, American, Southeast and East Asian, and European populations. The polymorphisms of ACE‐2 impact on the ACE2 protein structure and the binding capacity of the ACE‐2 receptor with the S‐Protein of SARS‐CoV‐2.
Beetroot Extracts as Haematopoietic Agents on Rats
Authors: Hikmawanti Ni Putu Ermi , Dwita Lusi Putri , Zahra Dinitia Az
Published: June 2021

Introduction: Beetroot (Beta vulgaris L.) contains flavonoid compounds that play a role in the haematopoietic process. It is known that methanol extract of beetroot has benefits in the process of haematopoiesis in normal white rats. Aims: To evaluate the beetroots extracts as hematopoietic agents on male rats. Methods: Beetroots dried powder was divided into two parts. One part was macerated separately with dichloromethane and 70% ethanol, while the other part is added with citric acid and washed with water to remove alkaloids and then extracted with 70% ethanol. The study used 24 rats which were divided into four groups. Each group consisted of 6 rats, namely the normal group, dichloromethane extract group, ethanolic extract group, and free alkaloids-ethanolic extract group. Each extract was given at a dose of 200 mg.Kg-1 for 21 days. Analyzed blood parameters are erythrocytes, haemoglobin, MCV, MCH, MCHC, leukocytes, and platelets. The data obtained consisted of the number of cells analyzed using one-way ANOVA then obtained by the Tukey test. Results: This study showed a significant increase in the number of erythrocytes, haemoglobin, MCV, MCH, MCHC, leukocytes, and platelets in rats that were given each extract compared to the normal group (p <0.05). The ethanolic extract of beetroot can increase erythrocytes, haemoglobin, MCV, MCH, MCHC, leukocytes, and platelets by 41.49%, 24.95%, 14.92%, 33.54%, 27.19%, 59.40%, and 35.37%, respectively. Conclusions: The ethanolic extract of beetroot has the potential as a good natural haematopoietic agent.
Development of New Isolation and Quantification Method of Piperine from White Pepper Seeds (Piper Nigrum L) Using A Validated HPLC
Authors: Kusumorini Nindya , Nugroho Akhmad Kharis , Pramono Suwijiyo , Martien Ronny
Published: June 2021

Most of the active pharmaceutical ingredients in the pharmaceutical world are obtained from natural ingredients, one of which is white pepper. White pepper seeds (Piper nigrum L.) contain the main alkaloid compound piperine, which has a broad spectrum pharmacological effect. This research aimed to isolate the piperine compound from white pepper seeds to make piperine more economical, simple, and effective so that it can be applied to large scale production in the pharmaceutical industry. The method of extracting and purifying piperine compounds was carried out using n-hexane and cyclohexane. The results of the isolated piperine were tested for their purity with a set of melting point apparatus, bidimensional TLC, and HPLC. The structure compound was then analyzed using FTIR and NMR. Furthermore, the isolated piperine was tested for its antioxidant activities using DPPH, ABTS, and FRAP. Cyclohexane was successfully used to remove the resinous matter from the n-hexane extract of white pepper to produce isolated piperine with 97.24% of purity. The results of the melting point, FTIR, 1H-NMR, and 12C-NMR of the isolated piperine were similar to that of the piperine reference substance and the literature review. The isolated piperine has weak antioxidant activities in the ABTS and FRAP test with the results of 15.25 ± 0.004 mM and 10.53 mol TE/g of the sample, respectively.
Perhitungan Kekuatan Rangka Dispenser-Lifter
Authors: Artanto Aditya Widhi , Darmo Suryo
Published: June 2021

Pekerjaan mengangkat beban yang dilakukan manusia membutuhkan energi. Kebutuhan energi cukup besar untuk pekerjaan yang berat. Salah satu pekerjaan mengangkat yang sering dilakukan adalah mengangkat galon air minum ke atas dispenser yang posisinya tinggi. Pengangkatan air minum dalam kemasan galon ke dispenser tidak mudah dilakukan setiap orang. Karena hal tersebut, studi ini membuat meja dispenser yang bisa di geser naik turun dengan bantuan alat pengangkat berupa gear reducer, kawat sling dan penggulung. Meja dispenser diturunkan pada posisi terbawah pada saat memasang galon, sehingga dapat dilakukan dengan ringan.  Penelitian ini dilakukan untuk menghitung kekuatan dispenser-lifter, yang dilakukan pada bagian (titik) yang kritis. Desain disesuaikan untuk tingkat keamanan yang tinggi. Berdasarkan pengukuran dan kalkulasi kekuatan, didapatkan bahwa tegangan kombinasi sambungan las pada tiang penyangga sebesar 48,1 N/mm2 dan pada titik kritis meja sebesar 18,42 N/mm2. Tegangan ijin setiap sambungan las adalah 88 N/mm2, sehingga alat aman untuk digunakan.
ASPECTOS DA EDUCAÇÃO INFORMAL NA COLÔNIA BLUMENAU: o caso da linguiça Blumenau
Authors: Rebollar Paola Beatriz May
Published: June 2021

Este artigo dá continuidade a uma reflexão que vem sendo realizada sobre as construções realizadas pelos imigrantes em Santa Catarina no confronto entre os conhecimentos trazidos das regiões de origem e a realidade encontrada nas colônias. Focalizamos aqui o segmento representado pelas famílias de imigrantes alemães que vieram para a antiga colônia Blumenau a partir de 1850 e seus descendentes empregando como fonte de informação os documentos presentes nos arquivos públicos locais e os relatos orais dos descendentes permitindo, de um lado, apreender as visões e vivências cotidianas desse grupo, e, de outro, obter informações valiosas sobre um produto em especial cuja receita foi e ainda é ensinada de geração em geração: a linguiça Blumenau. Este produto característico desta colônia em especial apresenta uma importância cultural até os dias atuais, mas o processo de ensino e aprendizagem envolvido na sua produção ao longo de mais de um século esteve a cargo de processos de educação informais, primeiro no âmbito da família e, posteriormente, no mundo do trabalho. A história da educação nas colônias teuto-brasileiras consiste num capítulo que promove a diversidade e demonstra a complexidade dos processos educacionais catarinenses e brasileiros. Conhecer a complexidade que integra a educação formal e informal é fundamental ao profissional da educação para pensar tanto o fazer pedagógico quanto seu papel na sociedade.
Entrevista al Dr. Raúl Contreras Bustamante
Authors: Flores Trejo Fernando Guadalupe , Uscanga Barradas Abril
Published: June 2021

Raúl Contreras Bustamante, Licenciado y Doctor en Derecho por la Universidad Nacional Autónoma de México, actualmente Doctor en Derecho por la Universidad de Salamanca, España. Miembro del Sistema Nacional de Investigadores (Nivel I); Investigador Honorario en El Colegio de Veracruz; Notario 29 de la decimoprimera demarcación del Estado de Veracruz (con licencia). Recipiendario de las Cátedras Extraordinarias “Raúl Cervantes Ahumada” y “Fernando Ojesto Martínez”, por la UNAM.; miembro fundador del Claustro de Doctores de la Facultad de Derecho de la UNAM; reconocido por la Asamblea Legislativa del Distrito Federal con la Medalla al Mérito Docente “Jaime Torres Bodet 2018”; recibió un premio por el Instituto Cultural México - Israel 2019, por su brillante trayectoria en diversos ámbitos como son: Las Ciencias, La Pedagogía, La Literatura, El periodismo, Las Artes y Comunicaciones. Recientemente, reconocido por el Congreso de la Ciudad de México con la Medalla al Mérito Docente 2019 “Prof. José Santos Valdés”. Profesor de Tiempo completo en la Facultad de Derecho de la UNAM, con más de 30 años de trayectoria impartiendo asignaturas de Teoría de la Constitución, Derecho Constitucional, Derecho Notarial y Registral, Poder Legislativo, Relaciones Interinstitucionales, Regímenes Constitucionales Comparados y Federalismo, así como, ha fungido como tutor principal y sinodal en más de sesenta exámenes de grado tanto de licenciatura, especialidad, maestría y doctorado. Colaborador Editorial permanente como columnista semanal en el periódico Excélsior y así como también ha sido columnista en diversas revistas de divulgación como Líder, Compromiso, Macroeconomía y El mundo del Abogado.
ON THE USE OF THE CENTRAL DIFFERENCE SCHEME FOR SOLVING THE PROBLEM OF GAS DYNAMICS
Authors:   I.I. Potapov Computer center of the FEB RAS, Potapov I.I. , Timosh P.S. ,   P.S.Timosh Computer center of the FEB RAS
Published: June 2021

The paper proposes a method for solving the problem of gas dynamics, implemented on the basis of a central difference scheme, the stability of which is achieved by performing a correction of the calcu-lated flows. It is shown that when solving the problem of discontinuity decay, the proposed method is stable, comparable in accuracy with the McCormack and Lax – Wendroff methods and surpasses them in performance.
DEVELOPMENT AND RESEARCH OF A NEURAL NETWORK AUTOTUNING UNIT FOR A PID CONTROLLER OF THE ENERGY FACILITIES AUTOMATED PROCESS CONTROL SYSTEM
Authors:   I.A. Shcherbatov National Research University ", Shcherbatov I.A. ,   MEI», Artushin V.A. ,   V.A. Artushin National Research University "MEI», Dolgushev A.N. ,   A.N. Dolgushev National Research University "MEI»
Published: June 2021

An adaptive control system based on a neural network autotuning unit has been developed. A method for training a neural network for an autotuning block has been examined. A comparison between a control system with a PID-controller and a control system with a PID controller and an autotuning unit has been made.
Variational Quantum Singular Value Decomposition
Authors: Wang Xin , Song Zhixin , Wang Youle
Published: June 2021

Singular value decomposition is central to many problems in engineering and scientific fields. Several quantum algorithms have been proposed to determine the singular values and their associated singular vectors of a given matrix. Although these algorithms are promising, the required quantum subroutines and resources are too costly on near-term quantum devices. In this work, we propose a variational quantum algorithm for singular value decomposition (VQSVD). By exploiting the variational principles for singular values and the Ky Fan Theorem, we design a novel loss function such that two quantum neural networks (or parameterized quantum circuits) could be trained to learn the singular vectors and output the corresponding singular values. Furthermore, we conduct numerical simulations of VQSVD for random matrices as well as its applications in image compression of handwritten digits. Finally, we discuss the applications of our algorithm in recommendation systems and polar decomposition. Our work explores new avenues for quantum information processing beyond the conventional protocols that only works for Hermitian data, and reveals the capability of matrix decomposition on near-term quantum devices.
Characterising and bounding the set of quantum behaviours in contextuality scenarios
Authors: Chaturvedi Anubhav , Farkas Máté , Wright Victoria J
Published: June 2021

The predictions of quantum theory resist generalised noncontextual explanations. In addition to the foundational relevance of this fact, the particular extent to which quantum theory violates noncontextuality limits available quantum advantage in communication and information processing. In the first part of this work, we formally define contextuality scenarios via prepare-and-measure experiments, along with the polytope of general contextual behaviours containing the set of quantum contextual behaviours. This framework allows us to recover several properties of set of quantum behaviours in these scenarios, including contextuality scenarios and associated noncontextuality inequalities that require for their violation the individual quantum preparation and measurement procedures to be mixed states and unsharp measurements. With the framework in place, we formulate novel semidefinite programming relaxations for bounding these sets of quantum contextual behaviours. Most significantly, to circumvent the inadequacy of pure states and projective measurements in contextuality scenarios, we present a novel unitary operator based semidefinite relaxation technique. We demonstrate the efficacy of these relaxations by obtaining tight upper bounds on the quantum violation of several noncontextuality inequalities and identifying novel maximally contextual quantum strategies. To further illustrate the versatility of these relaxations, we demonstrate monogamy of preparation contextuality in a tripartite setting, and present a secure semi-device independent quantum key distribution scheme powered by quantum advantage in parity oblivious random access codes.
Probing the edge between integrability and quantum chaos in interacting few-atom systems
Authors: Fogarty Thomás , García-March Miguel Ángel , Santos Lea F. , Harshman Nathan L.
Published: June 2021

Interacting quantum systems in the chaotic domain are at the core of various ongoing studies of many-body physics, ranging from the scrambling of quantum information to the onset of thermalization. We propose a minimum model for chaos that can be experimentally realized with cold atoms trapped in one-dimensional multi-well potentials. We explore the emergence of chaos as the number of particles is increased, starting with as few as two, and as the number of wells is increased, ranging from a double well to a multi-well Kronig-Penney-like system. In this way, we illuminate the narrow boundary between integrability and chaos in a highly tunable few-body system. We show that the competition between the particle interactions and the periodic structure of the confining potential reveals subtle indications of quantum chaos for 3 particles, while for 4 particles stronger signatures are seen. The analysis is performed for bosonic particles and could also be extended to distinguishable fermions.
On the Origin of the Commander Burundai
Authors:   Voronezh State University, Seleznev Yury V.
Published: June 2021

Research objectives: This work focuses on the origins of Amir Buruldai (also recorded as Burundai). He was an eminent military leader of the Horde during the time of the Mongol conquests and an active participant in the seven-year-long Western campaign, defeating the main forces of the Principality of Vladimir at the Sit’ River. Research on the origin of the generals living at the time of formation of the Mongol Empire and the Golden Horde is not a simple task. Synchronous and late sources carry information mainly about the relatives of Chinggis Khan and his closest associates. Biographies of many participants of the Western campaign are reconstructed with great difficulty; almost nothing is known about them, or extremely confusing, fragmentary, and contradictory information is found. Amir Buruldai can be included among such figures, left in the shadow of Chinggis Khan, his children, and grandchildren. A famous Mongol commander, Buruldai is distinguishable in the sources during the conquest of Eastern Europe and the campaigns against Hungary and Poland. In the research literature, the figure of Burundai is given some attention. However, he is mentioned occasionally in connection with the fate and lives of Russian princes, and a complete biography or historical portrait was not made. This is largely due to the state of the source material. Its information does not give us a clear picture of one of the more illustrious generals of the time of the Mongol-Tatar conquests. At the same time, a holistic picture of the life and activities of individual military commanders during the Mongol conquests, reconstructed on the basis of written sources, can give us valuable information for generalizations about warfare waged by the Mongol Empire and the ulus of Jochi, its development in a historical perspective, and the impact on the development of weapons and warfare among neighboring countries and peoples. Research materials: The main sources of information about Burundai are epic and chronicle works of Mongolian and Chinese origin, as well as Persian and Russian chronicles. Additional and indirect information is provided by official documentation and archaeological material. Results and novelty of the research: This article concludes that among the persons mentioned in written sources, Ogelen-cherbi can be considered the most plausible figure for Boorchu’s brother. Accordingly, he is to be recognized as the father of Buraldai. The latter, in all probability, was born in about 1200.
The Yarliq of Tokhtamish Khan to King Władysław II Jagiełło of Poland: The Problem of the Old Russian Text’s Origins
Authors:   Russian Presidential Academy of National Economy and Public Administration, Polekhov Sergey V.
Published: June 2021

Research objectives: The aim of the article is to trace the origins of the Old Russian text of Tokhtamish Khan’s 1393-dated yarliq-letter to King Władysław II Jagiełło of Poland, as well as the place and time of its emergence. Research materials: The Turkic and the Old Russian texts of Tokhtamish Khan’s 1393 yarlıq-letter to King Władysław II Jagiełło of Poland, as well as published and unpublished auxiliary materials. Results and novelty of the research: It is established that the Old Russian text of Tokhtamish Khan’s 1393 yarlıq-letter to Władysław II Jagiełło of Poland was written down in the royal chancery by the king’s Ruthenian scribe, Małochiej. This text was a record of the embassy of the khan’s envoys which explains its additional information when compared to the Turkic original.