bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Pelatihan dan Motivasi terhadap Produktivitas Karyawan di Bank Rakyat Indonesia Syariah Kantor Cabang Bandung Suniaraja
Authors: Fauzi Yasir Muharram , Dewi Diana Nurfadila
Published: September 2022

This research was conducted to find out how much influence the Training and Motivation on Employee Productivity at Bank Syariah Syariah Bandung Branch Office Suniaraja. This study employs associative quantitative method, with a population of all bank employees and using saturated or census samples so that a questionnaire of 42 is needed to determine employee responses. Use the same pattern. In addition to data from questionnaires that were processed using the IBM SPSS Statistics 23 application, the authors also obtained data from experts' theories about training and motivation for employee productivity to strengthen analysis.Theresults showed that the trigger event was dominated by motivation rather than training. This can be seen from the test results between the two variables after the indicators are entered, the validity test, the validity test and other calculation results.As if combined between the two, this study revealed that the existence of training and providing motivation is very influential on employee productivity.
Effect of Yarn Physical Properties on Fiber Migration and Packing Density of Cotton/Acrylic Blended Yarns
Authors: ÇELİK Halil İbrahim , GÜLİSTAN Canlı
Published: September 2022

In the scope of the study, the effect of fiber blending ratio, yarn count and twist coefficient on fiber migration, packing density and diameter of the cotton/acrylic blended yarns were investigated. The yarn samples with 75-25%, %50-50%, 40-60% cotton-acrylic blending ratios were produced with three different yarn numbers; 20/1 Ne, 24/1 Ne, 30/1 Ne and three twist coefficients; 3.5 α, 4 α, 4.5 α. Thus, totally 27 yarn samples were obtained. The yarn cross-sectional samples were sliced with microtome. The image frames of yarn cross-sections were acquired via digital microscope. The yarn packing density was calculated by using image processing algorithm and the fiber migration was determined via cross-section images. The results were evaluated statistically.
ДЕРЖАВНА ПОЛІТИКА У СФЕРІ СМАРТ-СПЕЦІАЛІЗАЦІЇ РЕГІОНІВ
Authors: Кудин Соломія , Федик Мар’яна
Published: September 2022

Стаття присвячена розвитку державної політики у сфері смарт-спеціалізації регіонів. Мета дослідження – розробити заходи удосконалення державної регіональної політики у сфері смарт-спеціалізації. Для досягнення мети у процесі дослідження використовуються загально-наукові методи пізнання такі як аналіз (аналіз наукової літератури та експертних думок), синтез (виділення ключових ідей, проблем), індукція та дедукція (на основі вивчення зарубіжного досвіду виокремлення напрямів державної політики у сфері смарт-спеціалізації, що будуть адаптованими до умов регіонального розвитку України в умовах післявоєнного відновлення). У процесі дослідження визначено актуальність смарт-спеціалізації як ключового напряму інноваційного розвитку регіонів; показано суть смарт-спеціалізації та виокремлено її переваги серед інших напрямів інноваційного регіонального розвитку. За результатами проаналізованого зарубіжного досвіду смарт-спеціалізації регіонів Німеччини, Іспанії, Польщі, Фінляндії, Франції, Румунії визначено можливі напрями смарт-спеціалізації в Україні. Стаття містить дослідження поточного стану реалізації політики смарт-спеціалізації регіонів та відображає результати першого етапу збору інформації про інноваційний розвиток Харківської, Одеської, Запорізької областей. У дослідженні зазначається, що результати досліджень повинні бути адаптованими до умов післявоєнного відновлення. В окремих випадках вони вимагають повністю нових досліджень, актуальних майбутній економічній, демографічній та ринковій ситуації в країні. Незалежно від вибору стратегії інноваційного розвитку регіону державна політика повинна бути націлена на результативність, що вимагає повної реорганізації, зміни інструментів, методів та підходів державного управління. Наукову новизну формують практичні рекомендації з вирішення ідентифікованих проблем смарт-спеціалізації регіонального розвитку. Практичне значення дослідження полягає у можливості його реалізації у процесі побудови стратегій регіонального розвитку, що націлені на формування інноваційних кластерів за участі держави, громади та бізнесу.
СТРУКТУРА МЕХАНІЗМУ СТРАТЕГІЧНОГО РОЗВИТКУ ВІТЧИЗНЯНИХ ПІДПРИЄМСТВ
Authors: Олійник Тетяна , Коноплянко Денис
Published: September 2022

Сучасне зовнішнє середовище функціонування підприємства, посилення елементів невизначеності і непередбачуваності, прискорення науково-технічного і соціально-економічного розвитку значно ускладнили процеси управління і визначили необхідність розвитку стратегічного мислення керівників для розробки стратегій розвитку підприємства. Метою статті є дослідження структури механізму стратегічного розвитку вітчизняних підприємств. В роботі запропоновано авторське визначення поняття «стратегія підприємства». Розроблено механізм формування стратегії розвитку вітчизняного підприємства в умовах інформаційної економіки. Впровадження розробленого механізму в практику стратегічного розвитку вітчизняного підприємства дає можливість підвищити його конкурентоспроможність, збільшити обсяг продажів і знизити собівартість продукції.
ПЕРСПЕКТИВИ ПІСЛЯВОЄННОГО ВІДНОВЛЕННЯ СФЕРИ ТУРИЗМУ В УКРАЇНІ
Authors: Моца Андрій , Шевчук Сергій , Середа Наталія
Published: September 2022

У статті розкриті перспективи післявоєнного відновлення сфери туризму в Україні. Визначено, що сфера туризму внаслідок російсько-української війни сильно постраждала як в Україні, так і за кордоном. З’ясовано, що на противагу негативному впливу війни, сфера туризму продовжує функціонувати – так, за перші чотири місяці 2022 року сума туристичного збору становила 64 млн 611 тис. грн та майже на 65% перевищила аналогічний період 2021 року (тоді до бюджету надійшло 39 млн 206 тис. грн). У ході дослідження виокремлені такі перспективні напрямки повоєнного відновлення сфери туризму в Україні, як: розвиток ділового, освітнього, медичного, зеленого та воєнного туризму; розробка та реалізація програм (як державних, так і міжнародних) підтримки суб’єктів туристичної діяльності; забезпечення тісної співпраці між країнами у напрямку взаємопідтримки туристичної діяльності; підвищення інтересу іноземних туристів до пам’ятних маршрутів та повоєнних символічних місць; пошук нових методів та способів реалізації туристичних послуг тощо. Доведено, що у контексті відбудови сфери туризму в Україні варто взяти до уваги позитивний досвід зарубіжних країн у відбудові сфери туризму, яка постраждала внаслідок кризових явищ, а особливо через війну.
ПРИНЦИПИ ФУНКЦІОНУВАННЯ БАНКІВСЬКОЇ СИСТЕМИ УКРАЇНИ В УМОВАХ ВІЙНИ
Authors: Прокопенко Наталія , Мирончук Вікторія , Шепель Інеса
Published: September 2022

Стаття присвячена визначенню основних засад функціонування банківської системи України в умовах воєнного стану. Актуальність дослідження полягає в необхідності забезпечення стабільної роботи банківської системи, яка є стратегічно важливою для держави та громадян. Мета статті – визначити основні засади функціонування банківської системи в умовах війни як досвід, який може бути адаптованим іншими країнами, що стикаються із кризовими ситуаціями в економічному та політичному середовищі. Для досягнення поставленої мети визначено основні принципи функціонування банківської системи в умовах війни. За результатами аналізу поточного стану виокремлено проблеми, з якими зіткнулась банківська галузь, та запропоновано шляхи їх вирішення. В процесі дослідження застосовувались загальнонаукові методи, такі як аналіз, синтез, порівняння, індукція та дедукція. За результатами дослідження встановлено, що діяльність банківської системи в умовах війни повинна здійснюватися на принципах законності, економічної самостійності, незалежності, відповідальності за своїми зобов’язаннями, легальності банківських операцій, дотримання нормативів НБУ, забезпечення права вибору банківської установи фізичними особами, забезпечення виконання взятих на себе зобов’язань та збереження довіри громадян. Під час війни банківська галузь зіткнулась з багатьма проблемами: браком трудових ресурсів, загрозою кібератак, перевищенням лімітів касових залишків, арештом банківських рахунків, втратами за попередньо наданими кредитами. Для вирішення цих проблем необхідно забезпечити стабільне функціонування банківської системи під час війни, розвивати ризик-менеджмент, сприяти діджиталізації, популяризувати безготівкові рахунки, посилювати систему електронних платежів, заручитися міжнародною підтримкою. Практичне значення дослідження полягає в можливості застосовувати запропоновані відновлюючі заходи іншими країнами у кризових ситуаціях, які виникають в економічному та політичному середовищі.
EVALUATION OF EXPORT DIVERSIFICATION IN UKRAINE
Authors: Іванов Євген
Published: September 2022

The article looks into evolution of Ukrainian merchandise export through the lens of its diversification. Problems with export diversification in Ukraine are stipulated in key government strategic plans of economic development, so detailed examination of diversification processes becomes particularly important. Study applies advanced methodology to explore export diversification in Ukraine at extensive and intensive margins, as well as HS6-digit division of commodity groups to get the most accurate results. Export trends, geography and structural shifts are analyzed. Results of global recession of 2009 for structural changes in Ukraine’s exports are defined. The main factors of Ukraine’s export concentration are revealed. Challenges, posed by lack of exports diversification, for steady economic growth and development are emphasized. Key advantages and disadvantages of boosting export diversification through integration into global value chains are argued. Causes and consequences of geographical reorientation of Ukraine’s export are analyzed. Efficiency of Ukraine’s trade relations with China as a new biggest trade partner is estimated. Results of this study can be used in preparation of analytical materials on the development of Ukraine’s export potential and international specialization, as well as in elaboration of new Export Strategy of Ukraine.
ПРОВЕДЕННЯ НЕЙРОМАРКЕТИНГОВИХ ДОСЛІДЖЕНЬ ДЛЯ ПІДВИЩЕННЯ ЕФЕКТИВНОСТІ РЕКЛАМНОЇ ДІЯЛЬНОСТІ
Authors: Карпенко Лариса
Published: September 2022

Все більше відомих світових брендів використовують нейромаркетингові дослідження, до яких належать інструментальні та соціально-психологічні методи. У статті розглянуто нейромаркетингові дослідження як засіб підвищення ефективності рекламної діяльності. Загалом необхідність маркетингових досліджень обумовлена потребою отримання інформації для мінімізації або усунення маркетингових ризиків при прийняття рішень, що забезпечується шляхом наявності достовірних даних. Традиційні маркетингові дослідження попри наявність методів дослідження, які вже давно стали класичними, не завжди дозволяють отримати достовірну інформацію, через похибки, які виникають в процесі роботи з респондентами. Натомість нейромаркетингові дослідження покликані забезпечувати більш глибокий аналіз реакції мозкової активності потенційних чи реальних споживачів. Оскільки з розвитком інформатизації та діджиталізації споживач стає більш вибагливим, виникає необхідність розширення застосування інструментарію маркетингових та нейромаркетингових досліджень.
ЕКОНОМІЧНА БЕЗПЕКА БУДІВЕЛЬНОЇ ГАЛУЗІ В УМОВАХ ВИКЛИКІВ І ЗАГРОЗ ВОЄННОГО СТАНУ
Authors: Коба Олена
Published: September 2022

Стаття присвячена актуальним питанням забезпечення економічної безпеки будівельної галузі України в умовах воєнного стану. Проаналізовано збитки, завдані економіці України з моменту широкомасштабного вторгнення рф. З’ясовано проблеми діяльності будівельних підприємств (зруйнована інфраструктура, втрата логістичних зв’язків, призупинення діяльності багатьох підприємств, недостатність фінансових ресурсів, зниження трудового потенціалу, попиту, платоспроможності населення), які потребують розв'язання задля швидкого відновлення та забезпечення економічного зростання економіки країни. Визначено виклики та загрози економічній безпеці будівельної галузі України, пов’язані з воєнним станом. Окреслено заходи для посилення економічної безпеки діючих будівельних підприємств в сучасних умовах.
PEMULIHAN SOSIAL DAN EKONOMI MASYARAKAT TERDAMPAK TSUNAMI DI KABUPATEN PANDEGLANG UNTUK MENDUKUNG PEMBANGUNAN DAERAH BERKELANJUTAN
Authors: Hartono Dedy , Maarif Syamsul , Sari Deffi Ayu Puspito , Wilopo W
Published: September 2022

Post-disaster recovery had to be measured to determine the level of success of the recovery process whether it has returned to pre-disaster condition or conditions that are better than before the disaster or even worse than before the disaster. This study aimed to analyze the social and economic recovery of disaster-affected communities in order to support sustainable regional programs. This study used qualitative research method with a case study research design. The results of the study showed that social recovery in 3 years after the Tsunami, namely in 2021, is 100.08% with the indicator of recovered. Meanwhile, the economic recovery up to 3 years after the Tsunami, namely in 2021, at 99.59% has not yet reached the recovery indicator. The recovered category is based on the calculation results with numbers above 100%. The conclusion of this research was that the effective social and economic recovery will support sustainable regional development because community resilience will be formed. The process of social and economic recovery, the current social condition of the community has recovered on average and the economic condition of the community is nearing recovery, with minimal central government programs. This was due to the resilience of local governments and communities. A strong social and economic community will support the creation of the principle of "build back better and safer", so that people's lives will be better and safer than before the disaster occurred.
Solitary Fibrous Tumor of Orbit: Changes of Tumor Size and Tumor Contrast Enhancement
Authors: Choe Woo Seok , Park In-Ki , Won Kyu Yeoun , Shin Jae-Ho
Published: September 2022

Purpose: To report a case of solitary fibrous tumor of the orbit in a patient with changes in tumor size and contrast enhancement.Case summary: A 64-year-old male patient presented with dizziness, discomfort on eye movement, anosmia, and proptosis. Orbital computed tomography showed an enhancing mass in the right extraconal space, lateral to the medial rectus and inferior to the superior oblique muscle. The mass appeared to be a cavernous hemangioma and the patient was monitored for changes in mass size and eye movements. After 24 months of follow-up, the mass size and symptoms of right eyelid swelling, proptosis, and diplopia had increased. Excision and biopsy of the mass were performed under general anesthesia. The biopsy confirmed that the mass was a solitary fibrous tumor. The postoperative period was uneventful and no recurrence was observed at 6 months after surgery.Conclusions: Solitary fibrous tumor is a soft tissue tumor that rarely occurs in the orbit, and should be considered in cases with an intraorbital mass accompanied by increased size and changes in contrast enhancement on imaging.
Phosphene Attributes Depend on Frequency and Intensity of Retinal tACS
Authors: Kvašňák E , Orendáčová M , Vránová J
Published: September 2022

Phosphene is the experience of light without natural visual stimulation. It can be induced by electrical stimulation of the retina, optic nerve or cortex. Induction of phosphenes can be potentially used in assistive devices for the blind. Analysis of phosphene might be beneficial for practical reasons such as adjustment of transcranial alternating current stimulation (tACS) frequency and intensity to eliminate phosphene perception (e.g., tACS studies using verum tACS group and sham group) or, on the contrary, to maximize perception of phosphenes in order to be more able to study their dynamics. In this study, subjective reports of 50 healthy subjects exposed to different intensities of retinal tACS at 4 different frequencies (6, 10, 20 and 40 Hz) were analyzed. The effectiveness of different tACS frequencies in inducing phosphenes was at least 92 %. Subject reported 41 different phosphene types; the most common were light flashes and light circles. Changing the intensity of stimulation often induced a change in phosphene attributes. Up to nine phosphene attributes changed when the tACS intensity was changed. Significant positive correlation was observed between number of a different phosphene types and tACS frequency. Based on these findings, it can be concluded that tACS is effective in eliciting phosphenes whose type and attributes change depending on the frequency and intensity of tACS. The presented results open new questions for future research.
The Morphology Study of Rosmarinus L. Seedlings
Authors: Mammadova V. , Mammadova N.
Published: September 2022

In recent years, the interest in natural herbal medicines and essential oils obtained from them has increased significantly in medicine industry worldwide. Essential oils and products made from them are widely used in various fields of modern medicine, especially in aromatherapy, in traditional treatment methods. Therefore, the study of the composition of biologically active substances in essential plants is of special importance. From this point of view, the introduction of new types of medicinal plants, the study of their bioecological properties, and especially the expansion of research conducted for use in scientific medical practice regarding the pharmacological activity of essential oils obtained from them is very relevant. Among the mentioned prospective research objects, rosemary (Rosmarinus L.) species widely used in medicine and folk medicine in different regions of the world occupy a special place. Despite the great interest in this plant and the obtained essential oil in Azerbaijan, its biological properties, extraction and composition of the essential oil have not been thoroughly studied. Therefore, the introduction of new useful species belonging to the genus Rosmarinus L., the study of their bioecological characteristics, cultivation agrotechnics and biologically active substances on scientific grounds is in the spotlight with its relevance.
Diversification of Production Technology in Cultivation, Providing an Increase in Crop Yield
Authors: Mammadova P.
Published: September 2022

The article presents the results of research conducted in the Absheron Experimental Farm in 2018–2020. with the aim of developing an effective crop rotation scheme to increase yields from one plot based on diversification of production technology in cultivation. During the study, the number of weeds in the fields was determined (crop rotation and continuous cropping). As a result of cultivation, their number decreased significantly at the end of the growing season. Despite the same cultivation of crops, the number of weeds in the rotation per square meter was less than in the case of continuous cropping. According to the results of the study, depending on the crops, the number of root residues at a depth of 0–40 cm of plants varied on average over three years. During crop rotation, soybean residues per hectare were determined as 2.95 tons, winter wheat — 4.38 tons, maize — 5.65 tons, which, with continuous cropping per hectare, was 0.12 tons higher for soybeans, and 0.18 tons for winter wheat and for maize by 0.31 t. Different results were also obtained regarding the impact of diversification on crop yields as a key agrotechnical factor. According to the average indicators of research, the yield of soybeans in a crop rotation increased by 0.20 tons, wheat by 0.47 tons and corn by 0.41 tons per hectare compared to continuous cropping. In addition to the agronomic indicators analyzed by us, the study and study of their economic efficiency is also of economic importance. Depending on the crops, the profit per hectare of soybeans is 1162.9–1002.9 manats, winter wheat — 826.8–638.8 manats, maize — 2353.6–2143.6 manats, the profitability level is 121.5–104, 8%, 104.8–80.9% and 220.7–201.0%, respectively.
Strontium-doping promotes bone bonding of titanium implants in osteoporotic microenvironment
Authors: Geng Tengyu , Wang Yiru , Lin Kaili , Zhang Cheng , Wang Jing , Liu Ya , Yuan Changyong , Wang Penglai
Published: September 2022

Osteoporosis is a major challenge to oral implants, and this study focused on improving the osseointegration ability of titanium (Ti) implants in osteoporosis environment via surface modification, including doping of strontium ion and preparation of nanoscale surface feature. Our previous studies have shown that strontium (Sr) ions can enhance osteogenic activity. Therefore, we aimed to comprehensively evaluate the effect of hydrothermal treatment of Sr-doped titanium implant coating on bone-binding properties in the microenvironment of osteoporosis in this study. We fabricated Sr-doped nanocoating (AHT-Sr) onto the surface of titanium implants via hydrothermal reaction. The rough Sr-doping had good biological functions and could apparently promote osteogenic differentiation of osteoporotic bone marrow mesenchymal stem cells (OVX-BMSCs). Most importantly, AHT-Sr significantly promoted bone integration in the osteoporosis environment. This study provides an effective approach to implant surface modification for better osseointegration in an osteoporotic environment.
Serological cross-reactivity among common flaviviruses
Authors: Chan Kai Rol , Ismail Amni Adilah , Thergarajan Gaythri , Raju Chandramathi Samudi , Yam Hock Chai , Rishya Manikam , Sekaran Shamala Devi
Published: September 2022

TheFlavivirusgenus is made up of viruses that are either mosquito-borne or tick-borne and other viruses transmitted by unknown vectors. Flaviviruses present a significant threat to global health and infect up to 400 million of people annually. As the climate continues to change throughout the world, these viruses have become prominent infections, with increasing number of infections being detected beyond tropical borders. These include dengue virus (DENV), West Nile virus (WNV), Japanese encephalitis virus (JEV), and Zika virus (ZIKV). Several highly conserved epitopes of flaviviruses had been identified and reported to interact with antibodies, which lead to cross-reactivity results. The major interest of this review paper is mainly focused on the serological cross-reactivity between DENV serotypes, ZIKV, WNV, and JEV. Direct and molecular techniques are required in the diagnosis ofFlavivirus-associated human disease. In this review, the serological assays such as neutralization tests, enzyme-linked immunosorbent assay, hemagglutination-inhibition test, Western blot test, and immunofluorescence test will be discussed. Serological assays that have been developed are able to detect different immunoglobulin isotypes (IgM, IgG, and IgA); however, it is challenging when interpreting the serological results due to the broad antigenic cross-reactivity of antibodies to these viruses. However, the neutralization tests are still considered as the gold standard to differentiate these flaviviruses.
Prevalence and incidence of stroke, white matter hyperintensities, and silent brain infarcts in patients with chronic heart failure: A systematic review, meta-analysis, and meta-regression
Authors: Tan Sean , Ho Clare Elisabeth Si Min , Teo Yao Neng , Teo Yao Hao , Chan Mark Yan-Yee , Lee Chi-Hang , Evangelista Lauren Kay Mance , Lin Weiqin , Chong Yao-Feng , Yeo Tiong-Cheng , Sharma Vijay Kumar , Wong Raymond C. C. , Tan Benjamin Y. Q. , Yeo Leonard L. L. , Chai Ping , Sia Ching-Hui
Published: September 2022

Introduction

Heart failure (HF) is associated with ischemic stroke (IS). However, there are limited studies on the prevalence of IS, white matter hyperintensities (WMHs), and silent brain infarcts (SBIs). Furthermore, interaction with ejection fraction (EF) is unclear.

Methods

We searched three databases (viz., PubMed, Embase, and Cochrane) for studies reporting the incidence or prevalence of IS, WMHs, and SBIs in HF. A total of two authors independently selected included studies. We used random-effects models, and heterogeneity was evaluated with I2 statistic. Meta-regression was used for subgroup analysis.

Results

In total, 41 articles involving 870,002 patients were retrieved from 15,267 records. Among patients with HF, the pooled proportion of IS was 4.06% (95% CI: 2.94–5.59), and that of WMHs and SBIs was higher at 15.67% (95% CI: 4.11–44.63) and 23.45% (95% CI: 14.53–35.58), respectively. Subgroup analysis of HFpEF and HFrEF revealed a pooled prevalence of 2.97% (95% CI: 2.01–4.39) and 3.69% (95% CI: 2.34–5.77), respectively. Subgroup analysis of WMH Fazekas scores 1, 2, and 3 revealed a decreasing trend from 60.57 % (95% CI: 35.13–81.33) to 11.57% (95% CI: 10.40–12.85) to 3.07% (95% CI: 0.95–9.47). The relative risk and hazard ratio of patients with HF developing IS were 2.29 (95% CI: 1.43–3.68) and 1.63 (95% CI: 1.22–2.18), respectively. Meta-regression showed IS prevalence was positively correlated with decreasing anticoagulant usage.

Conclusion

We obtained estimates for the prevalence of IS, WMH, and SBI in HF from systematic review of the literature.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=255126, PROSPERO [CRD42021255126].
Pre-service teachers’ search strategies when sourcing educational information on the Internet
Authors: Zimmermann Maria , Engel Ole , Mayweg-Paus Elisabeth
Published: September 2022

Teachers need to be able to inform and justify their teaching practice based on available research knowledge. When searching for research knowledge, the Internet plays a crucial role as it allows teachers to search for and access evidence long after their own education at university. On the Internet, however, educational information can have varying levels of scientific groundedness (e.g., science articles or blogs from colleagues), and research indicates that (pre-service) teachers struggle to find, select, and evaluate online educational information. It is precisely for this reason that it is important to educate (pre-service) teachers on how to competently source online information. This study describes pre-service teachers’ search strategies when sourcing online educational information about the topic “students’ use of mobile phones in class.” It sheds light on their use of (1) basic or advanced search strategies and (2) the role of Internet-specific epistemological beliefs (ISEBs).N= 77 pre-service teachers conducted a realistic search on the Internet and selected those web items (WI) that they perceived relevant for justifying whether mobile phones should be used in class. Their sourcing behavior was screen-recorded and analyzed. Most selected WI were found via search engines of Google LLC (91.4%). Advanced search strategies were defined as (1) using two or more search engines (performed by 62.3% of participants), (2) adapting search terms and/or formulating new search terms (90.9%), (3) selecting at least one WI that was not listed among the first four ranks on the first search engine results page (54.7%), and (4) checking for the trustworthiness of the author/source (14.3%) or the quality of the content (13%). Binary logistic regressions were used to analyze the relationship between ISEBs and (1) search strategies and (2) science-relatedness of WI as dependent variables. The predictor ISEB did not contribute to the models, meaning that differences in participants’ ISEBs did not significantly relate to their search strategies nor to the science-relatedness of WI, all β ≤ |0.36|,Wald≤ 0.64,p≥ 0.43. The role of pre-service teachers’ search strategies is discussed with respect to teachers’ evidence-informed reasoning and its implications for teacher education.
Upregulation of an estrogen receptor-regulated gene by first generation progestins requires both the progesterone receptor and estrogen receptor alpha
Authors: Perkins Meghan S. , Louw-du Toit Renate , Jackson Hayley , Simons Mishkah , Africander Donita
Published: September 2022

Progestins, synthetic compounds designed to mimic the activity of natural progesterone (P4), are used globally in menopausal hormone therapy. Although the older progestins medroxyprogesterone acetate (MPA) and norethisterone (NET) have been implicated in increased breast cancer risk, little is known regarding newer progestins, and no significant risk has been associated with P4. Considering that breast cancer is the leading cause of mortality in women, establishing which progestins increase breast cancer incidence and elucidating the underlying mechanisms is a global priority. We showed for the first time that the newer-generation progestin drospirenone (DRSP) is the least potent progestin in terms of proliferation of the estrogen-responsive MCF-7 BUS breast cancer cell line, while NET and P4 have similar potencies to estradiol (E2), the known driver of breast cancer cell proliferation. Notably, MPA, the progestin most frequently associated with increased breast cancer risk, was significantly more potent than E2. While all the progestogens enhanced the anchorage-independent growth of the MCF-7 BUS cell line, MPA promoted a greater number of colonies than P4, NET or DRSP. None of the progestogens inhibited E2-induced proliferation and anchorage-independent growth. We also showed that under non-estrogenic conditions, MPA and NET, unlike P4 and DRSP, increased the expression of the estrogen receptor (ER) target gene, cathepsin D, via a mechanism requiring the co-recruitment of ERα and the progesterone receptor (PR) to the promoter region. In contrast, all progestogens promoted the association of the PR and ERα on the promoter of the PR target gene, MYC, thereby increasing its expression under non-estrogenic and estrogenic conditions. These results suggest that progestins differentially regulate the way the PR and ER converge to modulate the expression of PR and ER-regulated genes. Our novel findings indicating similarities and differences between P4 and the progestins, emphasize the importance of comparatively investigating effects of individual progestins rather than grouping them as a class. Further studies are required to underpin the clinical relevance of PR/ERα crosstalk in response to different progestins in both normal and malignant breast tissue, to either confirm or refute their suitability in combination therapy for ER-positive breast cancer.
The pathophysiology of osteoporosis in obesity and type 2 diabetes in aging women and men: The mechanisms and roles of increased bone marrow adiposity
Authors: Ali Dalia , Tencerova Michaela , Figeac Florence , Kassem Moustapha , Jafari Abbas
Published: September 2022

Osteoporosis is defined as a systemic skeletal disease characterized by decreased bone mass and micro-architectural deterioration leading to increased fracture risk. Osteoporosis incidence increases with age in both post-menopausal women and aging men. Among other important contributing factors to bone fragility observed in osteoporosis, that also affect the elderly population, are metabolic disturbances observed in obesity and Type 2 Diabetes (T2D). These metabolic complications are associated with impaired bone homeostasis and a higher fracture risk. Expansion of the Bone Marrow Adipose Tissue (BMAT), at the expense of decreased bone formation, is thought to be one of the key pathogenic mechanisms underlying osteoporosis and bone fragility in obesity and T2D. Our review provides a summary of mechanisms behind increased Bone Marrow Adiposity (BMA) during aging and highlights the pre-clinical and clinical studies connecting obesity and T2D, to BMA and bone fragility in aging osteoporotic women and men.
Correlation between vitamin D and poor sleep status in restless legs syndrome
Authors: Geng Chaofan , Yang Zhenzhen , Kong Xiumei , Xu Pengfei , Zhang Hongju
Published: September 2022

Background

Restless Legs Syndrome (RLS) is closely related to poorer sleep quality. Vitamin D can regulate sleep regulation, cell proliferation, and differentiation. To measure whether vitamin D has predictive value for poor sleep quality in RLS was our aim in this study.

Methods

To analyze the serum levels of 25-hydroxyvitamin D [25(OH)D] in 95 RLS patients. We used the Pittsburgh Sleep Quality Index (PSQI) to measure sleep quality. Subjects had been divided into a normal and poor-sleeper groups according to the PSQI score. Using correlation and regression analysis to explore underlying etiologies that affect sleep disorder in RLS patients.

Results

Patients in the poor-sleeper group had significantly lower vitamin D levels in comparison to the normal group. The serum vitamin D levels were negative correlate with PSQI scores after adjusting for confounding factors. In addition, regression analysis showed that vitamin D could act as a predictor for sleep disorders in RLS patients (odds ratio [OR] = 0.008, p = 0.004). The area under the curve (AUC), cut-off value, sensitivity, and specificity of serum vitamin D was 0.967 (95% CI 0.935–0.998), 16.84 ng/ml, 87.5%, and 93.7% by receiver operating characteristic (ROC) analysis.

Conclusion

Our study confirmed the relationship between poorer sleep quality and vitamin D in RLS. However, the causal relationship between vitamin D deficiency and RLS is currently inconclusive. The effect of vitamin D supplementation is needed to confirm as the therapeutic strategies for sleep disorders in RLS patients in future work.
Myeloid cell-derived catecholamines influence bone turnover and regeneration in mice
Authors: Kuhn Melanie R. , Haffner-Luntzer Melanie , Kempter Elena , Reber Stefan O. , Ichinose Hiroshi , Vacher Jean , Ignatius Anita , Tschaffon-Müller Miriam E. A.
Published: September 2022

Catecholamine signaling is known to influence bone tissue as reuptake of norepinephrine released from sympathetic nerves into bone cells declines with age leading to osteoporosis. Further, β-adrenoceptor-blockers like propranolol provoke osteoprotective effects in osteoporotic patients. However, besides systemic adrenal and sympathetic catecholamine production, it is also known that myeloid cells can synthesize catecholamines, especially under inflammatory conditions. To investigate the effects of catecholamines produced by CD11b+ myeloid cells on bone turnover and regeneration, a mouse line with specific knockout of tyrosine hydroxylase, the rate-limiting enzyme of catecholamine synthesis, in CD11b+ myeloid cells (THflox/flox/CD11b-Cre+, referred to as THCD11b-Cre) was generated. For bone phenotyping, male mice were sacrificed at eight and twelve weeks of age and harvested bones were subjected to bone length measurement, micro-computed tomography, fluorescence-activated cell sorting of the bone marrow, gene expression analysis, histology and immunohistochemistry. Support for an age-dependent influence of myeloid cell-derived catecholamines on bone homeostasis is provided by the fact that twelve-week-old, but not eight-week-old THCD11b-Cre mice, developed an osteopenic phenotype and showed increased numbers of neutrophils and T lymphocytes in the bone marrow, while CCL2, IL-6, IL-4 and IL-10 mRNA expression was reduced in sorted myeloid bone marrow cells. To investigate the influence of myeloid cell-derived catecholamines on fracture healing, mice received a diaphyseal femur osteotomy. Three days post-fracture, immunohistochemistry revealed an increased number of macrophages, neutrophils and cytotoxic T lymphocytes in the fracture hematoma of THCD11b-Cre mice. Micro-computed tomography on day 21 showed a decreased tissue mineral density, a reduced bone volume and less trabeculae in the fracture callus indicating delayed fracture healing, probably due to the increased presence of inflammatory cells in THCD11b-Cre mice. This indicates a crucial role of myeloid cell-derived catecholamines in immune cell-bone cell crosstalk and during fracture healing.
Targeting the non-classical estrogen pathway in neurodegenerative diseases and brain injury disorders
Authors: Koszegi Zsombor , Cheong Rachel Y.
Published: September 2022

Estrogens can alter the biology of various tissues and organs, including the brain, and thus play an essential role in modulating homeostasis. Despite its traditional role in reproduction, it is now accepted that estrogen and its analogues can exert neuroprotective effects. Several studies have shown the beneficial effects of estrogen in ameliorating and delaying the progression of neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease and various forms of brain injury disorders. While the classical effects of estrogen through intracellular receptors are more established, the impact of the non-classical pathway through receptors located at the plasma membrane as well as the rapid stimulation of intracellular signaling cascades are still under active research. Moreover, it has been suggested that the non-classical estrogen pathway plays a crucial role in neuroprotection in various brain areas. In this mini-review, we will discuss the use of compounds targeting the non-classical estrogen pathway in their potential use as treatment in neurodegenerative diseases and brain injury disorders.
False data injection attack detection in dynamic power grid: A recurrent neural network-based method
Authors: Zhang Feiye , Yang Qingyu
Published: September 2022

The smart grid greatly facilitates the transmission of power and information by integrating precise measurement technology and efficient decision support systems. However, deep integration of cyber and physical information entails multiple challenges to grid operation. False data injection attacks can directly interfere with the results of state estimation, which can cause the grid regulator to make wrong decisions and thus poses a huge threat to the stability and security of grid operation. To address this issue, we propose a detection approach against false data injection attacks for dynamic state estimation. The Kalman filter is used to dynamically estimate the state values from IEEE standard bus systems. A long short-term memory (LSTM) network is utilized to extract the sequential observations from states at multiple time steps. In addition, we transform the attack detection problem into supervised learning problem and propose a deep neural network-based detection approach to identify attacks. We evaluate the effectiveness of the proposed detection approach in multiple IEEE standard bus systems. The simulation results demonstrate that the proposed detection approach outperforms benchmarks in improving the detection accuracy of malicious attacks.
Secure power management strategy for direct torque controlled fuel cell/ supercapacitor electric vehicles
Authors: Oubelaid Adel , Taib Nabil , Rekioua Toufik , Bajaj Mohit , Yadav Arvind , Shouran Mokhtar , Kamel Salah
Published: September 2022

High reliability is recommended in hybrid electric vehicle applications. In this study, a secure power management strategy has been developed for a fuel cell—supercapacitor hybrid electric vehicle. In addition to its ability to detect the occurrence of failures in vehicle power sources, the proposed power management strategy isolates the faulty source and reconfigures the control scheme to always guarantee bus voltage stability and vehicle traction even in faulty situations. The developed power management strategy enhances vehicle comfort and prevents exhausting one source over another by allowing the fuel cell and the supercapacitor to operate at different power levels. The multiloop control scheme associated with the power sources is highly reliable since both sources can run the vehicle alone and regulate the bus voltage. Vehicle speed and torque controllers are simultaneously tuned using a particle swarm optimization algorithm. Torque and speed ripples are automatically minimized via the use of a new proposed cost function. This approach made the controller design easier and gave the designer the possibility to tradeoff between the variables to be minimized.
Research on prediction and realization path of carbon peak of construction industry based on EGM-BP model
Authors: Dai Dawei , Li Kexin , Zhao Shuhang , Zhou Biao
Published: September 2022

In order to actively respond to the global climate and environmental challenges, and to help achieve the goal of carbon peaking and carbon neutrality, China aims to achieve carbon peaking by 2030. As the main contributor of energy consumption, construction industry transformation is imminent. This paper focuses on the development trend of carbon emissions in Anhui construction industry in the next 20 years, and how to help Anhui construction industry achieve the carbon peak target. The research process and conclusions are as follows: 1) Through literature review and gray correlation analysis, seven important factors affecting the construction industry are identified. 2) The gray prediction EGM(1,1) model was adopted to forecast the carbon emissions of the construction industry in Anhui Province from 2021 to 2040. The research results show that carbon emissions will increase year by year in the next 20 years. 3) The EGM-BP neural network model was used to further predict the carbon emissions from the construction industry in 2021–2040. It is expected that the carbon emissions from construction industry in Anhui Province will show an “inverted U″ trend in the next 20 years, and is expected to reach its peak in 2031, after which it will start to decline. Based on the results of the above study, we provide support paths for achieving the carbon peak in the construction industry from the perspective of improving and developing the construction system, and provide policy suggestions for relevant departments to accelerate the construction industry and carbon peak construction in Anhui Province.
Microbiologically influenced corrosion: The gap in the field
Authors: Puentes-Cala Edinson , Tapia-Perdomo Valentina , Espinosa-Valbuena Daniela , Reyes-Reyes María , Quintero-Santander Diego , Vasquez-Dallos Silvia , Salazar Henry , Santamaría-Galvis Pedro , Silva-Rodríguez Ramon , Castillo-Villamizar Genis
Published: September 2022

Microorganisms have evolved to inhabit virtually all environments on the planet, from oceanic hot-seeps to pipelines transporting crude and refined hydrocarbons. Often microbial colonization of man-made structures results in the reduction of their service life requiring preemptive or corrective human intervention. Microbiologically Influenced Corrosion (MIC) is caused by a set of intricate bioelectrochemical interactions between a diverse group of microorganisms and metallic surfaces. The complexity of MIC microbiomes and their mechanisms as well as the logistics constraints of industrial facilities are factors to consider when choosing suitable analytical methods for MIC monitoring. These generally reflect only a partial view of the phenomenon and in consequence, might lead to ineffective mitigation measures. This paper acknowledges the discrepancies between the fieldwork for MIC monitoring and the currently available technological advancements. It also highlights the most pressing issues that operators have in the field in light of the diversity of the microbial key players present in corrosive microbiomes. Finally, it compiles and outlines a strategy for the integration of novel molecular approaches aiming for a practical and accurate assessment of the microbial threat.
Transcriptome sequencing analysis of the role of miR-499-5p and SOX6 in chicken skeletal myofiber specification
Authors: Liu Yi-Fan , Zhang Ming , Shan Yan-Ju , Pang Li-Chuan , Ji Gai-Ge , Ju Xiao-Jun , Tu Yun-Jie , Shi Shi-Ying , Bai Hao , Zou Jian-Min , Shu Jing-Ting
Published: September 2022

MicroRNAs (miRNAs) might play critical roles in skeletal myofiber specification. In a previous study, we found that chicken miR-499-5p is specifically expressed in slow-twitch muscle and that its potential target gene is SOX6. In this study, we performed RNA sequencing to investigate the effects of SOX6 and miR-499-5p on the modulation and regulation of chicken muscle fiber type and its regulatory mechanism. The expression levels of miR-499-5p and SOX6 demonstrated opposing trends in different skeletal muscles and were associated with muscle fiber type composition. Differential expression analysis revealed that miR-499-5p overexpression led to significant changes in the expression of 297 genes in chicken primary myoblasts (CPMs). Myofiber type-related genes, including MYH7B and CSRP3, showed expression patterns similar to those in slow-twitch muscle. According to functional enrichment analysis, differentially expressed genes were mostly associated with muscle development and muscle fiber-related processes. SOX6 was identified as the target gene of miR-499-5p in CPM using target gene mining and luciferase reporter assays. SOX6 knockdown resulted in upregulation of the slow myosin genes and downregulation of fast myosin genes. Furthermore, protein-protein interaction network analysis revealed that MYH7B and RUNX2 may be the direct targets of SOX6. These results indicated that chicken miR-499-5p may promote slow-twitch muscle fiber formation by repressing SOX6 expression. Our study provides a dataset that can be used as a reference for animal meat quality and human muscle disease studies.
Non-invasive prenatal testing for the detection of trisomy 13, 18, and 21 and sex chromosome aneuploidies in 68,763 cases
Authors: Zhang Yanchun , Xu Hongyan , Zhang Wen , Liu Kaibo
Published: September 2022

Objectives: Non-invasive prenatal testing (NIPT) has been widely used in recent years. According to clinical experience from all hospitals providing prenatal screening services in Beijing, we explored the feasibility of using NIPT for the analysis of common foetal aneuploidies among pregnancies.

Methods: In total, 68,763 maternal blood samples were collected from January 2020 to December 2020 at the Beijing prenatal diagnosis agency. Cases with positive screening results by NIPT detection were validated using prenatal diagnosis.

Results: In total, 920 cases had a high-risk NIPT result, and 755 cases were shown to be truly positive by a chromosome karyotyping analysis; the prenatal diagnosis rate was 82.07% (755/920). Of the920 cases, there were 164 cases of T21, 70 cases of T18, 38 cases of T13, 360 cases of SCAs and 288 cases of other chromosomal abnormalities. The positive rates of T21, T18, T13, and SCAs were 0.24% (164/68,763), 0.10% (70/68,763), 0.06% (38/68,763) and 0.52% (360/68,763), respectively. The sensitivity and specificity were 98.17% and 99.92% for T21, 96.15% and 99.93% for T18, and 100% and 99.95% for T13, respectively. The PPVs of T21,T18,T13 and SCAs were65.24% (107/164), 35.71% (25/70), 18.42% (7/38) and 31.39% (113/360), respectively. For all indications, there were more higher T21/18/13 in the high-risk group than in the low-risk group (comprising only cases of voluntary request), with a positive rate of 0.46% vs. 0.27% (p < 0.001), sensitivity of 99.16% vs. 91.30% (p = 0.02) and PPV of 56.73%vs.32.81% (p = 0.001), but there was no significant difference in specificity between the groups (p = 0.71). The detection indication with the highest PPV (100%) by NIPT was ultrasound structural abnormalities and ultrasound soft marker abnormalities for T21 and ultrasound structural abnormalities and NT thickening for T18 and T13. The PPVs of different clinical indications of T21 (p = 0.002), T13 (p = 0.04) and SACs (p = 0.02) were statistically significant.

Conclusion: The high specificity, efficiency and safety (non-invasiveness) of NIPT can effectively improve the detection rate of common chromosomal aneuploidy, thereby reducing the occurrence of birth defects. We should encourage pregnant women with NIPT-high-risk results to undergo a prenatal diagnosis to determine whether the foetus has chromosomal abnormalities. More importantly, the screening efficiency of NIPT in the low-risk group was significantly lower than that in the high-risk group. Therefore, the use of NIPT in low-risk groups should be fully promoted, and socioeconomic benefits should be considered.