bluuebunny/crossref_metadata_2025 huggingface dataset:
A RELIGIÃO EM FREUD A PARTIR DO ESTUDO DE ATOS OBSESSIVOS E PRÁTICAS RELIGIOSAS (1907) - TOTEM E TABU (1913)
Authors: Staub Martha Manso , Ricciardi Marilene Carvalho , Escobar Lúcio José Borba
Published: August 2023

Este artigo abordará, primeiramente, alguns fatos relacionados ao universo religioso que Sigmund Freud vivenciou desde a sua infância e que podemos supor que tenham embasado a sua teoria e como este a desenvolveu dentro do tema. Em seguida, sua visão sobre a religião, utilizando duas de suas obras: Atos obsessivos e Práticas Religiosas, de 1907, sendo o primeiro estudo sobre o assunto, em que ele faz uma analogia dos ritos religiosos com as atitudes propícias à neurose obsessiva. Totem e Tabu, de 1913, apresenta a origem do fenômeno religioso, nas religiões primitivas e a interpretação freudiana do sentimento deste. Esses apresentam fundamentos de como a psicanálise interpreta dois aspectos da experiência religiosa, principalmente, no que se refere à origem e natureza do fenômeno religioso, além da análise dos rituais.
VESTINDO AGRIMENSURA: A IDENTIFICAÇÃO DE UM CURSO.
Authors: DALRI JULIA CUCCO , CABRAL CESAR ROGÉRIO , DE FRANÇA ROVANE MARCOS
Published: August 2023

A memória de uma instituição de ensino pode ser analisada a partir de elementos que construíram sua história, dentre estes os uniformes formam uma identidade muito forte entre alunos e a escola marcando estes períodos. A partir do acervo de camisetas, de fotos e documentos do Museu de Topografia e Geodésia Professor Ênio Miguel de Souza foi realizada uma pesquisa denominada Vestindo Agrimensura sobre os uniformes utilizados pelos alunos entre as décadas de 1970 e 2000 na Escola Técnica Federal de Santa Catarina e em especial pelos formandos dos Cursos Técnicos que tinham a permissão para escolherem uma camiseta que os identificavam e os distinguiam dos demais alunos. No Curso Técnico em Agrimensura foram identificadas 25 camisetas de formandos a partir de 1994 retratando diversos aspectos relativos ao exercício da profissão e destacando os nomes dos concluintes. Pouco restou da memória desta instituição centenária, de seus cursos, de seus servidores e principalmente de seus alunos, mas sempre há tempo para iniciar o resgate de nossa história
CURADORIA DO CONHECIMENTO E APRENDIZAGEM BASEADA EM PROBLEMAS: METODOLOGIAS DE APOIO À ANDRAGOGIA
Authors: Viana André Luis Pullig , Lopes Gabriel Cesar Dias , De Sousa Nilton Elias
Published: August 2023

Com a revolução digital e o papel que a internet desempenha na vida das pessoas, o acesso à informação tornou-se mais fácil e rápido. Como resultado, os educandos são expostos a uma infinidade de conteúdos. É um desafio selecionar aqueles que realmente possam subsidiar a construção de um conhecimento sólido, crítico e relevante. Esta ação pode ser denominada de curadoria do conhecimento. Pensando na educação dos adultos os quais, não raramente, dividem o tempo de estudos com diversas outras atividades, há que se pensar em metodologias que facilitem o processo de ensino-aprendizagem. Assim, além da curadoria do conhecimento, temos a Aprendizagem Baseada em Problemas (ABP), metodologias essas, eficazes para aplicação, dentre outras, na andragogia. Dessa forma, propomos o seguinte problema de pesquisa: como a curadoria do conhecimento e a ABP podem ser úteis na andragogia. Os objetivos específicos são: definir curadoria de conhecimento; aprendizagem baseada em problemas; e andragogia. Cumpridos esses objetivos, chegaremos ao nosso objetivo geral: identificar na curadoria do conhecimento e na ABP elementos funcionais para aplicação na andragogia. Com isso, conseguiremos chegar à resposta para o nosso problema de pesquisa. A metodologia para este trabalho está pautada na pesquisa de natureza básica com abordagem qualitativa, de cunho exploratório-descritivo, com revisão bibliográfica e análise de conteúdo. O embasamento teórico está pautado em obras de: BARELL, CORTELLA e DIMENSTEIN, DEWEY, FOFONCA e CAMAS, FREIRE, HAMZE, KUBRUSLY LEITE e AFONSO, LOPES, SOMMER, MIHAILIDIS, MORAN, NOGUEIRA, SAUL e SAUL, SIZANOSKY, SOUZA, STEIMER, TOLEDO JÚNIOR, e repositórios eletrônicos de pesquisa.
APLICAÇÃO DOS FUNDAMENTOS DO ESPORTE NA GESTÃO DE PESSOAS DAS EMPRESAS
Authors: Pereira Licurgo Carvalho , Fita Rachel da Silva , Jankowitsch Jhonata
Published: August 2023

Com as transformações das relações de trabalho, ditadas pelo alto emprego de tecnologia, em um mundo cada vez mais globalizado e competitivo, são requisitados das empresas e seus líderes novas competências e recursos. O esporte demanda habilidades e estratégias que são imprescindíveis para o sucesso de qualquer empresa. Desde o planejamento de jogadas e estratégias, até a gestão de equipe e a liderança de um time, muitas lições podem ser aprendidas com o esporte. Neste artigo, serão explorados os fundamentos esportivos e suas aplicações no ambiente empresarial, passando pelo papel do líder nesse processo e mostrando como é possível utilizar os ensinamentos do esporte para atingir melhores resultados dentro das organizações.
AS CONTRIBUIÇÕES DA TECNOLOGIA NA APRENDIZAGEM DOS ALUNOS NA ETAPA DO ENSINO FUNDAMENTAL
Authors: Silva Conceição de Maria Viana , Campos Tiago Aparecido de Melo , Nyakuleha Osman H.
Published: August 2023

A tecnologia digital na educação possibilita encontrar novas respostas não apenas para o que as pessoas aprendem, mas também para como, onde e quando aprendem. A pesquisa que ora se apresenta tem o objetivo de de investigar sobre as contribuições da tecnologia enquanto recurso didático pedagógico, no processo de desenvolvimento dos alunos na etapa do Ensino Fundamental. Para a coleta de dados procedeu-se com uma revisão bibliográfica referente à temática proposta, quando foram revisados artigos científicos e livros, assim como visitas e análises em páginas da internet. Os resultados apontam para a ideia de que os professores necessitam continuamente encontrar maneiras de agregar a tecnologia em suas salas de aula para tornar o ensino mais interessante e que atenda às reais necessidades da nova geração de alunos.
O MUNDO REAL COMO FORÇA MOTRIZ NAS METODOLOGIAS ATIVAS
Authors: Dos Santos Fábio Francisco Costa , Sarmento Alexandre Guilherme Motta
Published: August 2023

Este trabalho pretende analisar estratégias de aprendizagem baseadas na solução de problemas reais, e, para tal, foram selecionadas três metodologias que possuem essas características: Aprendizagem Baseada em Problemas (ABP), Metodologia da Problematização ou Arco de Maguerez e a Aprendizagem Baseada em Projetos (PBL – “Problem Based Learning”).  Aspira-se identificar qual a importância da conexão do aprendizado com as experiências do aluno em seu meio, visando a solução de problemas do cotidiano e de natureza prática, trazendo à tona propostas para implementação e melhoria do mundo ao seu redor.  Utilizando-se da pesquisa bibliográfica, este estudo investiga os principais autores e suas pesquisas sobre o tema, fazendo uma análise detalhada de cada metodologia e da forma com que elas amparam um aprendizado mais efetivo. Pretende-se assim, trazer reflexões sobre como se processam as metodologias abordadas e trazer contribuições que possam apontar caminhos para a melhoria dos processos de ensino.
NAVEGANDO NO TERRITÓRIO POÉTICO DO RIO SÃO FRANCISCO – O GÊNERO LÍRICO NO ENSINO DA GEOGRAFIA E DA BIOLOGIA
Authors: De Oliveira Érico Anderson , De Oliveira Rosália Caldas Sanábio , Tiago Fabiana da Conceição Pereira
Published: August 2023

O corrente artigo visa cooperar com as discussões acerca do ensino das disciplinas de Geografia e Biologia na Educação Básica ao comunicar uma prática educativa interdisciplinar em quatro turmas do 1º ano do Ensino Médio Integrado do Centro Federal de Educação Tecnológica de Minas Gerais (CEFET-MG), em Belo Horizonte, trazendo como centro de investigação o rio São Francisco por meio do gênero lírico. Nesta contextualização, aprecia-se esse gênero presente no livro infantojuvenil “Formosuras do Velho Chico”, de Lalau e Laurabeatriz, considerando-o como um dispositivo textual e visual capaz de coadjuvar na absorção de conceituações estruturais tanto da Geografia, quanto da Biologia, analisando-se, assim, as referências biogeográficas/ambientais e culturais da poesia e de suas representações artísticas sobre o rio na obra priorizada para esse trabalho didático-pedagógico. A temática ambiental explorada por intermédio da literatura infantojuvenil e do gênero lírico se converte em um aparato substancial de percepção ambiental. O livro e o gênero lírico se tornam, aqui, os interlocutores entre o “território poético” do rio São Francisco, a sua biogeografia e a extrapolação refletida sobre sua realidade neste planejamento didático com o encaminhamento dado pelos professores.
LAND REALLOCATION FOR AN UPGRADED URBAN DEVELOPMENT PLAN IN RWANDA: A CASE STUDY OF PLANNING FOR UPGRADING KABUYE PHASE II SITE/GASABO DISTRICT, KIGALI CITY
Authors: Habiyaremye Jean Pierre
Published: August 2023

Land is required for development of basic public infrastructure. Compensation for current rights holders of such land must be negotiated. Also, the resulting subdivisions will thus be smaller than the original portions of land, and the parcellation exercise will mean that households do not hold the same portion of land they held originally. All of these aspects can lead to conflicts over land if not properly managed. Kigali City Master plan 2050 has its main objective of making a smart city particularly Kabuye Phase II site is rising growth trajectory requires rapidly expanding infrastructure facilities to support it with making detailed Physical planning as a key component of urban development initiatives and sets the boundaries that will help to have Access to affordable infrastructure services for consumption purposes serves to improve household welfare through resident initiative. The detailed topographic survey of the area was undertaken. Secondary data was obtained from the District level and other stakeholders. The Kigali City master plan provides useful information while the Google Earth Pro platform proved beneficial. Existing parcels were 2125 Parcels with informal planning having area of 156ha. The new plot and different land use have proposed as Residential with 1902 new plots, off-core commercial, Road, Pathway and 1252 Parcels have remained as Existing one but arranged referring to the planning and total cost of priorities activities within the site is 1,430,661,116Frw. Each plot will be contribute land at 23.84% and financial contribution in order to finalize this project will be 632,924frw by new one plot to be developed and 181,182frw/previously permitted and previously constructed plot. However, there are still some serious concerns evident in the newly readjusted area. These should be viewed as recommendations to be taken into account by future project implementers and partners, particularly the local government units overseeing the project sites. The most important emerging issues are the growing income disparity with the exclusion of the poorest from the development process.
BLENDED OPEN DISTANCE LEARNING (ODL) CHALLENGES IN 21ST CENTURY: PRIMARY FINDINGS FROM ODL STUDENTS FROM MALAWI
Authors: Nyakuleha Osman H. , Simengwa Davie
Published: August 2023

The purpose of this study was to investigate and document the challenges facing Open and Distance Learning students at the Central Christian University (CCU) and other institutions of higher learning in Malawi. The study was conducted at CCU Blantyre main study centre with 8 institutions which offer programs on ODL. The study employed both qualitative and quantitative approaches. The main data collection techniques were questionnaires and structured interviews, supplemented by documentary review. Tables, frequencies and percentages were the key descriptive statistics used to analyse and present the findings. The results showed that ODL learners were challenged with a range of obstacles in their course of studies. The most reported challenges were lack of sufficient time for study, difficulties in access and use of ICT, ineffective feedback and lack of study materials. It was recommended that CCU should strive to achieve effective and balanced teaching and learning system that satisfies the desire of the learners to the extent that they would wish to come back to the institution for further studies and feel proud to recommend the institution to others who are seeking for knowledge.
A BIOESTATISTICA ASSOCIADA A EPIDEMIOLOGIA NA ATENÇÃO BÁSICA DE SAÚDE
Authors: De Souza Bruno Rocha , Santacroce Luigì , Oh Henry
Published: August 2023

Objetiva-se  por intermédio do presente estudo compreender como o conhecimento em bioestatística   associado a epidemiologia influencia e pode ser aplicado na atenção básica de saúde.O estudo trata-se de uma revisão bibliográfica, possuindo carater exploratório e descritivo e desenvolvido pelo método qualitativo, através de artigos científicos e obras literárias que respondam os questionamentos levantados , sem recorte temporal, no idioma português, pesquisadas nas bases de dados LILACS, MEDLINE, BDTD, Google acadêmico, SciELO e periódicos da CAPES. Conclui-se que  a bioestatística  e a epidemiologia quando associadas, proprociona principalmente ao profissional de saúde na atenção básica, a entender e a compreender comportamentos ou situações que  envolvam a população como um todo ou parte dela.
NEUROBUSINESS: O DIFERENCIAL DA MULHER NO MUNDO EMPRESARIAL
Authors: Santiago Patrícia Rosany de Sales , Utnick-Brennan Sophia Iris Moreira , Abril Lorena Lemes Balestra , De Albuquerque Ana Tavares , Pinheiro Mônica de Sá , Rodrigues Fabiano de Abreu Agrela
Published: August 2023

A saga sobre as diferenças entre homens e mulheres é contrariada pela neurociência, que demonstra a inexistência de uma dicotomia rígida entre os gêneros. Desta forma, este artigo aborda a influência das características neurobiológicas e sociais femininas no sucesso empresarial em uma perspectiva bibliográfica qualitativa, destacando como destacar como essas particularidades podem ser utilizadas para criar valor no ambiente de negócios e impulsionar o sucesso das organizações. O cérebro humano é altamente adaptável, moldado pelas experiências e influências do ambiente ao longo da vida, conforme evidenciado por estudos sobre neuroplasticidade. As características de gênero, como traços de personalidade e comportamentos, apresentam ampla sobreposição entre homens e mulheres, desafiando visões dicotômicas. Embora a comunicação e a empatia sejam habilidades frequentemente associadas às líderes femininas, outras competências também são cruciais para o sucesso no ambiente de negócios. A perspectiva interseccional destaca a complexidade das desigualdades entre mulheres e destaca a necessidade de uma mudança cultural para alcançar uma maior igualdade de gênero.
THE USE OF ACTIVE METHODOLOGIES FOR THE PROCESS OF INCLUSIVE EDUCATION IN NATURAL SCIENCE CLASSES
Authors: Souza Jorge Raimundo da Trindade , Santos Heloísa Glins , Santos Deusivaldo Aguiar , Souza Natalia Soares Santa Brígida Trindade , De Carvalho Ricardo Haroldo , Machado Jorge Ricardo Coutinho , Castro George Anderson Macedo
Published: August 2023

This qualitative study aimed to evaluate the use of active methodologies in experimental Science classes associated with inclusive education from an investigative perspective with characteristics similar to the Problem-Based Learning (PBL). To do so, three Science experiments were adapted for students with visual impairments in basic education. Results indicate that school and social inclusion are possible by means of active assistive activities. It is concluded that students with visual impairments achieved learning objectives through the development of adapted teaching materials, with active participation from the students in this process. This confirms the effectiveness of the methodology used in these activities and highlights the need for successful active practices to overcome the inherent obstacles of inclusive education.
Delirium Awareness and Management of Intensive Care Nurses in Terms of Their Personality Traits
Authors: EREN Nursel , TAŞDEMİR YİĞİTOĞLU Gülay
Published: August 2023

Objective: The study was carried out to determine delirium awareness and management among the nurses working in intensive care in terms of their personality traits.

Method: It was a descriptive study. The study was carried out in a university hospital located in the western region of Turkey between February May 1 and May 31, 2019. The sample was composed of 84 nurses who were working in the adult intensive care unit. Data collection form, The Nurses’ Delirium Knowledge Questionnaire, and the Big Five Personality Trait Test were used to collect data. Data were evaluated with t-test, ANOVA, Mann-Whitney U, Kruskal-Wallis H, Bonferroni Corrected Pairwise Comparison Test, and Spearman Correlation coefficient using SPSS 24.0 package program.

Results: The total mean personality score of the nurses was 158.38±14.32. The total delirium knowledge score of the participants was found to be 44.77±9.83. Knowledge score of the nurses regarding the definition of delirium was found to be negatively correlated with the personality trait of extraversion whereas their delirium sign/symptom scores were positively correlated with conscientiousness, agreeableness and total big five personality trait score. In addition, positive correlations were found between delirium management score and their conscientiousness, neuroticism, and big five personality trait scores and between their total delirium knowledge score and personality trait of conscientiousness (p
Hemşirelik Öğrencilerinin Acının Dönüştürücü Gücü Kavramına İlişkin Algılarının Metafor Analizi Yöntemiyle Belirlenmesi
Authors: KAPLAN Tuğçe , GÜNBAYI İlhan , KESER İlkay
Published: August 2023

Amaç: Araştırmanın amacı, hemşirelik öğrencilerinin acının dönüştürücü gücü kavramına ilişkin algılarını metafor analizi yöntemiyle incelemektir.

Yöntem: Araştırmanın örneklemini 2020-2021 eğitim-öğretim yılı Ekim-Mart ayları arasında eğitim gören 103 hemşirelik öğrencisi oluşturmuştur. Araştırmada nitel ve nicel verilerin birlikte toplandığı karma yöntem desenlerinden yakınsak paralel karma desen kullanılmıştır. Araştırmanın nicel boyutunda öğrencilerin sosyodemografik ve ruhsal acı yaşama deneyimleri gibi değişkenler; nitel boyutunda metafor analizi yöntemi kullanılmıştır.

Bulgular: Araştırmaya katılan öğrencilerin %76.7’sinin kadın, %43.7’sinin 4. Sınıf öğrencisi, %63.1’inin ruhsal acı yaşadığı görülmüştür. Çalışma sonucunda metaforların 8 kavramsal kategoride toplandığı ve öğrencilerin en sık hayvan, bitki ya da doğa unsurları kategorisine ilişkin metafor seçtikleri (%32) görülmüştür. İnsana ait bir duygu ya da duygusal davranış kategorisi ile çevresinde ruhsal acı yaşayan birey olma durumu arasında (p=0.005); Aile üyesi, arkadaş ya da danışılacak bir insan kategorisi ile de ruhsal acı veren olay türü (p=0.008) arasında anlamlı bir ilişki saptanmıştır. Diğer kategoriler ile sosyodemografik veriler arasında herhangi bir ilişki saptanmamıştır (p>0.05).

Sonuç: Sonuç olarak hemşirelerin hastalık/durum hakkındaki algılarının bireye sunulan hemşirelik bakımını etkilediği düşünüldüğünde öğrencilerin ruhsal acı yaşayan bireye bakım vermeye ve bireyin değişip dönüşebilmesine ilişkin olumlu bir yargı geliştirdiği ve meslek hayatında bu yargıya yönelik hareket etme potansiyelinin olduğu söylenebilir.
Human is a Social Being: Socializing in Pandemic Times
Authors: MALAK AKGÜN Bahanur , ÖZKAN Burcu
Published: August 2023

Objective: It was aimed to evaluate the news of national television that revealed the ways people socialize during the first year of the pandemic in Turkey.
Methods: According to the ethnographic qualitative research design, the news showed between 11 March 2020 and 11 March 2021 in the news of six national channels in Turkey and containing the forms of socialization were analyzed by content analysis.
Results: Life did not fit at home, the form of socialization changed and this new form of socialization evolved in the direction of digitalization. Those who have kept up with the digital age have realized their socialization experiences by spending time on social media. Neighbors began communicating by gathering on balconies, rather than being guests in one another's homes. Society have made an effort to cope with uncertainty and obscurity by returning to localness and living its traditions. Coping with challenges in the belief that they would be resolved together has enabled Turkish society to cope more successfully with the pandemic process.
Conclusions: This study will be a precursor to support multidisciplinary studies in community mental health studies in times of crisis, will provide important data for community mental health promotion practices.
CLINICAL GUIDELINES FOR THE DIAGNOSIS AND TREATMENT OF CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION
Authors: Editorial Article
Published: August 2023

Designed by experts of the Russian Medical Society on Arterial Hypertension Approved at the meeting of the Russian Medical Society on Arterial Hypertension December 11, 2015 and the profile commission of Cardiology November 25, 2015 Moscow, 2015
CLINICAL CASE: OPPORTUNITY OF THERAPY OPTIMIZATION DUE TO TRANSITIONING FROM SILDENAFIL TO RIOCIGUAT IN PATIENT WITH IDIOPATHIC PULMONARY HYPERTENSION
Authors: Taran I. N. , Paramonov V. M. , Valieva Z. S. , Saidova M. A. , Nakonechnikov S. N. , Martynyuk T. V. , Chazova I. Ye.
Published: August 2023

SUMMERY The patient with diagnosis of idiopathic pulmonary hypertension, functional class III (WHO) was treated by anticoagulants, diuretics. After 6 months of treatment with phosphodiesterase type 5-inhibitor sildenafil, there was observed the negative dynamic with systolic pulmonary arterial pressure, intolerance to exercises. The treatment goals were not achieved with sildenafil therapy. The transitioning from sildenafil to riociguat therapy was done. By 6 months of the riociguat therapy there was achieved the significant improvement of the functional and hemodynamic status. Ам^^ to the stratification risk scale the treatment goals were reached. Keywords: idiopathic pulmonary hypertension, phosphodiester-ase type 5 inhibitor, sildenafil, soluble guanylate cyclase stimulators, riociguat, risk assessment.
DISTRIBUTION OF POLYMORPHISMS OF GENES OF STATINS METABOLISM AND TRANSPORT IN THE LIVER IN PATIENTS WITH CORONARY ARTERY DISEASE ETHNIC UZBEKS WITH SIMVASTATIN INTOLERANCE
Authors: Shek A. B. , Kurbanov R. D. , Abdullayeva G. J. , Nagai A. V. , Abdullaev A. A. , Ahmedova S. S. , Hoshimov S. U. , Ziyaeva A. V.
Published: August 2023

Background. It is well-known that in majority of cases treatment with statins can be safe and well tolerated, but in some patients observed statin-induced adverse liver or muscle symptoms - the main reasons for statin discontinuation. Asian ethnicity - is one of the predisposing factors for statin-associated adverse effects.

Objective. To study possible effects of CYP3A5 (6986A>G), CYP2C9 (430C>T), CYP2C9 (1075A>C), SLCO1B1 (521T>C) and BCRP (ABCG2, 421C>A) genetic polymorphism on simvastatin tolerance and safety in ethnic Uzbek patients with Coronary Artery Disease (CAD).

Material and methods. The prospective case-control research included 100 patients with CAD. Group "case" were 50 patients who demonstrated statin-induced adverse liver effects (transaminase level increases 3 times and more - in 37 cases) or statin-induced elevations in serum CK (of >3*UNL - in 4 cases) at treatment with simvastatin with the dose of 20 mg/day for 3 months of treatment and 13 with myopathy, associated with increased levels of total creatine phosphokinase (CPK) 3 times or more. In 4 patients with adverse effects on the liver, along with an increase in the enzymes, while there was an increase of CPK levels. Control group contained 50 patient with CAD treated with simvastatin with the dose of 20-40 mg/day for one year without side effects. The both groups of patients were similar in gender, age, original index of kidney function and serum CK level. The comparison group consisted of healthy ethnic Uzbeks (n = 41) of comparable age and sex, with the absence of a family history of coronary artery disease. The research was performed by means of PCR-RFLP method.

Results. As a whole, all genotypes (except for CYP2C9 * 2 in patients) were in Hardy-Weinberg equilibrium. Among patients with simvastatin intolerance, compared to the control group, the following genotypes were observed more frequently with high level of confidence: CYP3A5 *3/*3, compared to genotype variants *1/*3 and *1/*1 (OR 9.33; 95% CI 3,37-25,9; P = 0.0001) and BCRP CA (patients with BCRP CC genotype were not observed among those examined) (OR 3.22; 95% CI 1,258,30, P = 0.024).

Conclusions. Genotypes CYP3A5 *3/*3 (6986A>G) and BCRP CA (ABCG2, 421C>A) are accompanied with the increase of statin-induced adverse effects in ethnic Uzbek patients with Coronary artery disease.
ANEMIA OF CHRONIC DISEASE AS A RISK FACTOR IN PATIENTS WITH CORONARY ARTERY DISEASE AND LESION OF THE LEFT MAIN CORONARY ARTERY
Authors: Abdullaeva S. Ya. , Nikishin A. G. , Pirnazarov M. M. , Yakubbecov N. T. , Khasanov M. S. , Yuldashev N. P. , Ganiev A. A. , Bobojonova N. J.
Published: August 2023

Aim: The authors assess anemia as a predictor of poor outcome in patients with lesions of the left main coronary artery.

Material and methods. The study included 112 patients of both sexes with a lesions of the left main coronary artery, in combination with the defeat another one coronary artery, according coronary angiography, were hospitalized in RSCC in the 2015-2016 years.

Result. The authors found that in most cases, anemia in patients with coronary heart disease is not of iron and therefore iron administration is useless. In addition, anemia is an independent predictor of adverse outcomes in patients with coronary artery disease with lesions of the left main coronary artery. In the complex groups of patients needed correction and monitoring of hemoglobin levels, in order to prevent a decrease and increase it above the recommended values.
THE EFFICIENCY OF BOSENTAN BASED ON THE DATA OF THE REGISTER OF PATIENTS WITH PULMONARY HYPERTENSION IN THE VORONEZH REGION
Authors: Korolkova O. M.
Published: August 2023

Introduction. To improve the diagnosis, to examine the prevalence, structure, evaluation of effectiveness of therapy it is necessary to create register of pulmonary hypertension.

The purpose of the study: to study the efficacy, the safety of the drug bosentan in patients with idiopathic pulmonary hypertension (ILG) according to the register of the Voronezh region.

Material and methods. The Material was the data base of the register. Results. Analyses the prevalence, the incidence of ILG. Peculiarities of clinical course depending on the hemodynamic and functional status of patients of ILG.

Conclusion. The efficacy and safety of the drug bosentan in ILG.
CLINICAL CASE OF COMBINATION THERAPY INCLUDING AMBRIZENTAN IN THE PATIENT WITH SEVERE IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION
Authors: Movsisyan G. A. , Arkhipova O. A. , Korobkova I. Z. , Matchin Yu. G. , Saidova M. A. , Martynyuk T. V. , Chazova I. Ye.
Published: August 2023

Idiopathic pulmonary hypertension (IPAH) is a rare cardiovascular disease of unknown etiology, but the most common form of pulmonary arterial hypertension, defined as mean pulmonary arterial pressure >25 mmHg and pulmonary vascular resistance >3 Wood Units. Endothelial dysfunction seems to play an integral role in the pathogenesis of IPAH: the activation of endothelin-1 causes the hypertrophy of smooth muscle cells and endothelial cells, fibrotic changes, immune inflammation and vasoconstriction which leads to small pulmonary arteries and arterioles remodeling. The endothelial system activation is the reason for using endothelin receptor antagonists (ERA) to block the endothelin receptors type A (ETA) or both types (ETA, ETB). ERA, as the main class of PAH-specific therapy, is presented by bosentan and macitentan, dual endothelin receptor antagonists, and ambrisentan, non-sulfonamide, ETA-selective ERA. This clinical case demonstrates the successful treatment with ambrisentan as the part of combination therapy in the patient with severe IPAH.
ABSTRACTS OF THE V EURASIAN CONGRESS OF CARDIOLOGISTS, SEPTEMBER 11-12, 2017, BISHKEK, KYRGYZSTAN
Authors: Editorial Article
Published: August 2023

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DABIGATRAN ETEXILATE IN ELDERL Y PATIENTS WITH ATRIAL FIBRILLATION: WHATS NEW?
Authors: Tkacheva O. N. , Vorobyeva N. M.
Published: August 2023

The article discusses stroke prevention in elderly patients with atrial fibrillation. The principles of choosing anticoagulant therapy in this group of patients are discussed. The importance of the safety profile of the selected anticoagulant is emphasized considering the high prevalence of comorbidities in elderly patients. The efficacy and profile of dabigatran etexilate demonstrated in randomized clinical trials and in real clinical practice is analyzed in detail. Based on the data discussed, the authors are coming to conclusion that dabigatran can be considered the preferred anticoagulant for long-term treatment in elderly patients with atrial fibrillation.
CLINICAL FEATURES OF PULMONARY ARTERIAL HYPERTENSION ASSOCIATED WITH CONGENITAL SYSTEMIC-TO-PULMONARYSHUNTS
Authors: Gratsianskaya S. Ye. , Arkhipova O. A. , Zorin A. V. , Martynyuk T. V. , Chazova I. Ye.
Published: August 2023

Pulmonary arterial hypertension (PAH), associated with congenital heart disease (CHD) (PAH-CHD), despite the similarities of histological lesions, is а different from other forms of PAH. PAH-CHD is represented by a heterogeneous patient population with varying defect locations, concomitant diseases, indications and contraindications to surgical correction; also, some patients have a history of a defect closure. According to the European guidelines for the diagnosis and treatment of pulmonary hypertension 2015, there are four main groups in the clinical classification of PAH-CHD: 1) Eisenmenger’s syndrome, 2) PAH associated with prevalent systemic-to-pulmonary shunts, 3) PAH with small/concidental defects, 4) PAH after defects correction. The evolution of the guidelines for the surgical correction of CHD has seen in recent years. Risk stratification has a great importance for further prognosis, response to treatment and timing of surgical correction. For optimal treatment carefulness and expertise in diagnosis and differential diagnosis should be exercised. A better understanding of clinical features, risk stratification and the assessment of the impact of a genetic background will help to determine the best clinical management, which is associated with better quality of life and improved survival in patients with PAH-CHD.
CARDIOPULMONARY EXCERSISE TESTING IN RISK STRATIFICATION IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION AND CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION
Authors: Taran I. N. , Valieva Z. S. , Martynyuk T. V. , Chazova I. Ye.
Published: August 2023

In recent years the information about relevance of cardiopulmonary exercise testing (CPET) in complex assessment of pulmonary arterial hypertension (PAH) patients and chronic thromboembolic pulmonary hypertension (CTEPH) patients have been accumulating. Parameters of CPET, such as peak oxygen consumption (Vo2 peak) and ventilation equivalents (VE/Vco2) are very important in risk stratification in patients with PAH, also as distance in 6-minute walking test, the echocardiography and right heart catheterization results, N-terminal prohormone of natriuretic peptide according to the European Society of Cardiology and European Respiratory Society guidelines on diagnosis and treatment of pulmonary hypertension. However, there are no parameters, which can be used in clinical practice to reflect the risk of mortality during 1 year in patients with CTEPH. The aim of our study was to assess the role of CPET in risk stratification, achieving therapy goals and making decision about therapy escalation in patients with PAH and CTEPH. Results of our pilot study demonstrated, that CPET parameters are the reliable markers to reflect the PAH and CTEPH progression. The CPET is necessary for pathogenic therapy efficacy assessment and for making decision of therapy escalation in patients with PAH, also as in CTEPH patients. The critical role of CPET in risk stratification in PAH and CTEPH patients should be emphasized.
METEOSENSITIVITY AMONG MENTAL WORKERS
Authors: Bekhbudova J. A. , Bakhshaliyev A. B. , Akhmedova B. J.
Published: August 2023

This study investigates the incidence of meteosensitivity (MS) and its manifestations among intellectual workers, and the correlation between MS and psychological states of the patients. Patients were administered a standardized questionnaire of risk factors (RF) of cardiovascular disease (CVD), including MS; CES-D questionnaire to reveal depression; and self-monitoring map. Incidence of MS was established in 99 of 196 intellectual workers (50.5%): 34 men (40%) and 65 women (58.6%). In a group of 33 volunteers with MS, 45.5% were revealed to have various degrees of depression. Among people who exhibited manifestations of depression, the number of days of feeling unwell Physiological meteosensitivity (MS) - the property of the body to maintain its health by harmonizing life-supporting processes with solar, geophysical, meteorological and other processes in the environment. In a healthy person with good reserve capabilities of adaptation mechanisms, internal processes caused by physiological MS do not cause any painful sensations. In the case of the weakening of the body due to illness, stress, or exhaustion person may experience pathological meteopathic reactions, often complicating the course of the underlying disease, reducing the effectiveness of treatment, and worsening the patient’s quality of life. Differences in atmospheric pressure, especially spasmodic, negatively affect the circulatory system, vascular tone, and arterial pressure. High humidity also has negative effects on health. During periods of so-called “magnetic storms”, a deterioration of wellbeing is even possible in a completely healthy person, manifested by disturbance in memory and concentration and occurrence of nervous breakdowns. Cardiac patients are most sensitive to various changes in weather conditions [1-5]. It is noticed that people living in cities suffer from meteorological dependence much more than those who live in rural areas. This is in relationship to weather conditions significantly exceeded that of people who exhibited no depressive signs. Most people in the observation group complained of worsening in self-perceived well-being during the days in which the combination of northern or southern winds, high atmospheric pressure, and high humidity was registered. Sensitivity to showers was recorded in 69.7% of individuals with MS. Results of this study confirm the potential utility of providing self-management education to patients with MS and development of personalized programs for alleviating severity of individual’s reaction to fluctuations in certain meteorological parameters.
ADAPTATION OF ELECTRONIC SYSTEM FOR ISCHEMIC HEART DISEASE PREDICTION AS A STEP TO COMMON INFORMATION SPACE IN CARDIOLOGIC HEALTHCARE
Authors: Trigulova R. K. , Tashkenbayeva N. F. , Azimova N. A. , Akhmedov D. D. , Bazarov R. K. , Shek A. B.
Published: August 2023

Electronic version of a patient’s individual card protocol forming “Analytic system for monitoring and predicting various clinical variants of ischemic heart disease (CHD DM2)” database № BGU 00314 is combined with the computer system № DGU 01035 to assess yearly risk of adverse events by diagnostic coefficients; up-to-date prognostic signs, such as pre-test probability, Duke treadmill score and ventricular ejection fraction participating in the formation of prognostic conclusion were added. The database is a complex of program products intended for automation of dynamic management processes for both inpatients and outpatients with various clinical IHD forms and concurrent type 2 diabetes mellitus based on assessment of the disease course dynamics, completeness of prescriptions and patient’s compliance. The proposed model is of high clinical practical significance since it can be transformed into electronic medical history or used as a database in chronic IHD registry to improve medical care quality.
RIGHT VENTRICULAR MYOCARDIAL INFARCTION IN A PATIENT WITH CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION AGAINST THE BACKGROUND OF SMALL CORONARY ARTERIES
Authors: Arkhipova O. A. , Kuznetsova E. G. , Martynyuk T. V. , Chazova I. Ye.
Published: August 2023

Most often acute myocardial infarction of the right ventricle is diagnosed in patients with acute left ventricular lesion and is associated with an atherosclerotic process in the coronary arteries. Isolated acute myocardial infarction of the right ventricle is rarely diagnosed and is often detected only during autopsy. Previously it was believed that in the absence of a significant lesion of the coronary arteries, an acute myocardial infarction of the right ventricle is associated with hypertrophy of the right ventricular myocardium. The results of a study in which acute myocardial infarction of the right ventricle were found in patients who died due to acute massive pulmonary embolism and who did not have right ventricular hypertrophy appeared later. There are many questions regarding the tactics of therapy for this complication, especially in patients with pulmonary hypertension who are on treatment with pulmonary arterial vasodilators. The article describes a rare clinical case of postmortem detection of myocardial infarction of the right ventricle against the background of small coronary arteries in a 41-year-old patient with a diagnosis of chronic thromboembolic pulmonary hypertension, the difficulties of intravital diagnosis and the restriction of drug therapy.
ROSUVASTATIN - THE MOST POTENT STATIN IN CARDIOVASCULAR DISEASE PREVENTION
Authors: Semenova A. E. , Sergienko I. V.
Published: August 2023

Rosuvastatin is a statin with maximum hypolipidemic effect, to date, which makes it one of the most frequently prescribed lipid-lowering medications. The drug has been widely studied in large international randomized clinical trials and proven to be highly effective. Administration of rosuvastatin at doses of up to 40 mg/day allows to decrease low-density lipoprotein cholesterol (LDL-C) levels by 55-63%, triglyceride levels by 28% and to significantly increase the level of high-density lipoprotein cholesterol by 10-14%. The effectiveness of rosuvastatin for primary prevention of CV complications has been indicated in high and very high risk patients, as well as in intermediate-risk persons and patients with mildly elevated base LDL-C level. The ability of rosuvastatin to suppress the progression of atherosclerosis has been demonstrated by intravascular ultrasound of coronary arteries and by magnetic resonance imaging of carotid arteries. Rosuvastatin is a hydrophilic statin with high hepatoselectivity, low systemic bioavailability (very limited penetration of rosuvastatin into extrahepatic tissues and, hence, lower risk of myotoxicity) and minimal involvement of P450 cytochrome in its metabolism (mostly mediated by 2C9 enzyme), which provides for good tolerability of the drug. High hepatoselectivity and the absence of any significant interaction with cytochrome P450 system mitigate the likelihood of side effects and drug interactions. The above mentioned characteristics of rosuvastatin enable its effective and safe use in treating a wide range of patients.
CLINICAL CASE OF REPLACEMENT OF ENDOTHELIN RECEPTOR ANTAGONIST (BOSENTAN) BY SOLUBLE GUANYLATE CYCLASE STIMULATOR (RIOCIGUAT) IN THE PATIENT WITH PULMONARY ARTERIAL HYPERTENSION
Authors: Devetyarova E. A. , Dyuzhikov A. A. , Dyuzhikova A. A. , Sobin S. V. , Sumin A. V. , Pashchenko E. V.
Published: August 2023

Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by progressive increase in pulmonary vascular resistance (PVR), higher pulmonary arteries mean pressure (mPAP), decrease in cardiac minute output (CMO) and other hemodynamic, functional and biochemical disorders. Existing PAH therapeutic algorithm, described in the European and Russian clinical guidelines, mainly suggest strategy of sequential combination therapy in the case of inadequate response to initial monotherapy. At this, switching from one PAH-specific drug to another is studied to a lesser extent. At the present similar approach (switching) has already been tested, for example, in switching from one endothelin receptor antagonist (ERA) to another, or from phosphodiesterase type 5 inhibitor (iPDE-5) to soluble guanylate cyclase stimulator (sGC). There are virtually no data about change of monotherapy when drugs target different molecular pathways of vascular tone regulation, in particular, in the pulmonary circulation vessels. This article describes clinical case of female patient with FC III pulmonary arterial hypertension (WHO) switched from therapy by endothelin-1 receptor antagonist (bosentan) to soluble guanylate cyclase stimulator (riociguat). Female, 37 years old, with verified by the right heart catheterization (RHC) diagnosis of idiopathic PAH (iPAH) received PAH-specific monotherapy of bosentan. Due to condition deterioration on the background of bosentan dose increase, medical conference decided to switch this patient to another class of PAH-specific therapy (sGC stimulator riociguat) with consequent follow-up. As a result of such approach positive changes in patient's condition, improvement of hemodynamic parameters, increased tolerance of physical exercise was demonstrated in comparison with previous therapy. This clinical case demonstrates safe and successful transfer from bosentan to riociguat in the patient with idiopathic PAH. Similar tactic for the change of therapy should be studied in further clinical trials.
DEVELOPMENT OF CONCEPTS NOMENCLATURE FOR CLINICAL DECISION SUPPORT SYSTEM IN DIAGNOSTICS OF ANGINA PECTORIS
Authors: Kiselev K. V. , Potekhina A. V. , Osyaeva M. K. , Noeva E. A. , Vyborov O. N. , Zorin A. V. , Shvyrev S. L. , Martynyuk T. V. , Zarubina T. V. , Chazova I. Ye.
Published: August 2023

Introduction. Since 2000th CHD morbidity in Russia is growing constantly, especially, angina pectoris morbidity. Increasing workload on physicians due to high number of patients makes us find the ways to optimize human resource applying. One of the possible ways is development of clinical decision support systems, particularly, ontology-based systems. These ontologies must adopt semantic interoperability for the concepts included, to be clearly interpreted by physicians of different medical schools.

Research target. Develop the concepts nomenclature for building of angina pectoris ontology. Methods. For primary concepts extraction we used state clinical recommendations “Stable coronary heart disease” issued in 2016. Development and filling of the nomenclature were performed in MS Excel and MS Excel Online. The work through the primarily extracted concepts was performed with expert-cardiologists by cross-validation method and common voting on final inclusion of the concept in the nomenclature. The final nomenclature validation was performed by semi-automatic method on anonymized 610 electronic health records of the patients.

Results. After primary extraction of the concepts without experts, we could extract 336 basic concepts and 144 synonyms, keeping in mind the aspects of this nomenclature development. The shared work through this nomenclature with the expert-cardiologists let us increase the number of the basic concepts up to 409 and the number of the synonyms up to 619. The nomenclature validation on electronic health records showed compliance of the concepts in aspects of diagnostics methods and medicine prescriptions and 92% compliance in diagnostic signs, which doctors evaluate in diagnostics results. Percentages of primarily extracted concepts in draft nomenclature and after being worked through by the experts and also validation results based on electronic health records, let us make a conclusion that clinical recommendations can be used as a basic data source for concepts extraction, but the draft result must be evaluated by the experts and also filled up with the usage of additional knowledge sources about angina pectoris, and after that the nomenclature can be used for angina pectoris ontology development.

Conclusion. The usage of clinical recommendations is proved to be the basic data source for concepts of subject area extraction. However, the draft nomenclature must be evaluated and filled up with additional synonyms and validated on electronic health records. After that, the extracted concepts and their synonyms can be used for ontology development.
SERUM ALDOSTERONE LEVEL DYNAMICS AND CARDIAC REMODELING IN MYOCARDIAL INFARCTION PATIENTS WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA TREATED WITH SELECTIVE ALDOSTERONE RECEPTOR BLOCKER
Authors: Miroshnichenko E. P. , Dranenko N. Y. , Goryanskaya I. Y. , Gagarina A. A. , Ushakov A. V.
Published: August 2023

Aim. To study serum aldosterone level dynamics and cardiac remodeling characteristics in myocardial infarction (MI) patients with undifferentiated connective tissue dysplasia (UCTD) treated with selective aldosterone receptors antagonist eplerenone.

Study population and methods. A total of 110 MI patients with and without UCTD and 32 healthy controls without cardiovascular pathology and without signs of UCTD were enrolled in the study. Clinical examination, phenotyping, echocardiography and serum aldosterone levels evaluation were performed. MI patients were divided into 3 groups: I (n=20) - patients with UCTD who was treated by eplerenone additionally to basic therapy of MI; II (n=60) - patients without UCTD treated by basic therapy of MI; III (n=30) -patients with UCTD treated by basic therapy of MI only.

Results. All MI patients regardless of UCTD presence had increased serum aldosterone in the first day of MI. In 28 days the significant increase of serum aldosterone level in group I in comparison with groups II, III and control group was observed. Analysis of structural and functional characteristics of the heart in MI patients in a 6 month after MI had shown more significant left ventricle enlargement and decrease of cardiac pump function in group III compared to group I.

Conclusion. Presence of UCTD in MI patients does not affect serum aldosterone levels dynamics. Inclusion of eplerenone in the treatment of MI patients with UCTD during 6 months inhibits left ventricular dilatation and attenuates reduction of its ejection fraction.
Eriogyna pyretorum (Lepidoptera, Saturniidae) parasitoid species investigated in Fujian, China
Authors: Lin Hao Yu , Wang Jia Jin , Mao Xin Jie , Liao Song Kai , Chen Hui
Published: August 2023

Eriogyna pyretorum Westwood is a notorious defoliator of Camphora officinarum Nees that causes large economic and ecological losses in planted forests. To understand the importance of suppressing the population of E. pyretorum on natural parasitoids, a four-years investigation was conducted in the field. Four egg parasitoid species Ooencyrtus kuvanae Howard, Trichogramma chionis Ishii, Telenomus sp. and Anastatus dexingensis Sheng & Wang were captured in the wild. One of these is the dominant endoparasitoid species T. chionis, which has a quicker developmental time (8.33 d), more offspring (8.39/egg) and a greater parasitism rate (89.54%). With different elevation distributions, the parasitism rates for Kriechbaumerella longiscutellaris Qian & He, Gregopimpla himalayensis (Cameron), Theronia depressa (Gupta) and Xanthopimpla konowi (Krieger) were 17.29%, 2.10%, 4.23% and 0.83%, respectively. Female longevity (47.75 d), offspring (13.36/pupa) and sex ratio (1.16:1) were compared in four pupal parasitoids and K. longiscutellaris was the most abundant species of E. pyretorum in Fujian Province.