bluuebunny/crossref_metadata_2025 huggingface dataset:
Operationalising user behaviour: a study on the life cycle assessment of smart home technologies
Authors: Tippe Mareike , Wigger Henning , Brand-Daniels Urte , Vogt Thomas
Published: January 2025

Background

Smart home technologies (SHT) make it easier than ever to track energy demands and are expected to contribute to the implementation of sustainability strategies. In particular, they are supposed to enable promising demand side management strategies by altering user behaviour towards sustainability while ensuring the balance of energy supply and demand.

For determining environmental impacts of products and technologies, the methodology of life cycle assessment (LCA) is an established tool. While large parts of LCAs are standardised, the consideration of user behaviour related effects has not been specified. By adopting an interdisciplinary perspective, this literature study contributes to the future development of a standardized methodology for the operationalisation of behaviour in LCAs.

Results

Three main strategies for operationalising behaviour in LCA studies were identified: (1) behaviour theory-based approaches, (2) model-based behaviour predictions and (literature-based) deductions, and (3) averages and assumptions. The results of this literature study show that the selection of the strategy is crucial as the user behaviour and methods used for LCAs have a significant impact on the environmental and economic payback periods and calculated overall impact of SHTs. Findings from the social sciences on practices and household activities that can be influenced by SHTs, are not systematically applied.

Conclusions

Our literature analysis makes it clear that LCA results depend on various factors. Selected operationalisation and methodological approaches, respectively, can play a key role. Depending on the method chosen the results can vary by several orders of magnitude and are not always comparable. Simplified approaches for integrating user behaviour into LCAs like assumptions and average values can be a first step in accounting for the relevance of behaviour. However, it is important to bear in mind that these approaches may not reflect actual user behaviour, as this can be subjected to a limited changeability of certain household practices and habits. On the basis of the results, the authors recommend greater interdisciplinary co-operation in the conduction of LCAs on SHTs, ranging from a common definition of the scope, to the implementation of socio-scientific research and survey methods, to the derivation of policies.
Improved capacitance of NiO and nanoporous silicon electrodes for micro-supercapacitor application
Authors: Thamri S. , Raouadi M. H.
Published: January 2025

We investigated the NiO/PS/Si and the NiO/Si electrodes to highlight the effect of the PS porous silicon on the enhancement of the electrode performance. We elaborated the PS with the stain etching method, whereas the NiO nickel oxide was synthesized using sol–gel and deposited through the spin coating technique. We showed that PS porous silicon significantly increased the active surface area and improved the electrical and electrochemical properties. Thus, we obtained promising results for NiO/PS/Si. The effective series resistance and interfacial resistances were reduced from 1.8 Ω cm2 and 42 Ω cm2 to 0.05 Ω cm2 and 0.29 Ω cm2 from NiO/Si to NiO/PS/Si, respectively. The capacitance increased from 12.34 µF cm−2 for NiO/Si to 9.64 mF cm−2 for NiO/PS/Si. We found similar capacity values from the CV cyclic voltammetry curves and IS impedance spectroscopy Nyquist plots. We obtained equivalent effective series resistance values from the charge–discharge and Nyquist plots, confirming our results. The NiO/PS/Si electrode showed good stability with only a 3% loss for 5000 galvanostatic cycles. The energy efficiency is estimated from the charge–discharge curves to be 91%.
Asymmetric risk contagion effect of the interaction between the real economy and the financial sector—an analysis based on the domestic commodity price index
Authors: Yonghui Quan , Wenlong Miao
Published: January 2025

As the uncertainty of the global economy intensifies, domestic real economy risks and financial risks may interact and worsen under international risk shocks. Commodity prices are an important channel for transmitting international economic and financial risks. Taking January 2007 to July 2021 as the sample period and using data from nine commodity price indices and banking, diversified finance, and insurance industry indices, this article uses rolling regression method to construct different commodity price risk and financial sector risk indicators. Combined with a vector autoregressive model, the risk contagion effect is calculated. The analysis indicates that there exist significant asymmetric risk contagion effects between various commodities (with energy and steel having the largest risk spillover effects) and there are significant net risk spillover effects on financial sectors (with insurance having the largest risk spillover effect). There are asymmetric risk contagion effects among different financial sectors, with varying degrees of risk spillover effects on commodity prices (with the banking sector having the greatest risk spillover effects on commodity prices and other financial sectors, and diversified finance having the greatest risk spillover effect on commodities). During major global financial events, the risk spillover effects of commodities and input effects increase significantly due to the intensification of the risk spillover effects of energy, steel, and nonferrous metals. The risk spillover effect between commodities and the overall risk spillover effect have significantly increased. The financial sector’s overall net risk input effect has increased, while the net risk input effect of the insurance sector has also increased. These findings are significant for improving systemic financial risk monitoring indicators and adopting accurate prevention and control measures.
Lymphatic leaks – success of intranodal lymphangiogram first strategy
Authors: Campbell Alan , Velazquez-Pimentel Diana , Seager Matthew , Hesketh Richard , Hague Julian , Raja Jowad , Brookes Jocelyn , Ngo An , Walkden Miles , Papadopoulou Anthie , Smith Daron , Mohammadi Borzoueh , Barod Ravi , Akhtar Mohammed Rashid , Tun Jimmy Kyaw , Low Deborah Elise , Renfrew Ian Daniel , Fotheringham Tim , von Stempel Conrad
Published: January 2025

Background

Lymphatic leaks are associated with significant mortality and morbidity. Intranodal lymphangiography (ILAG) involves the direct injection of ethiodised lipid into the hilum of lymph nodes. It is diagnostic procedure that can have therapeutic effects secondary to a local sclerosant effect. The aim of the study is to describe the technical and clinical success of ILAG and adjunctive lymphatic interventions performed as first line interventional techniques for lymphatic leaks refractory to conservative and medical management in a multicentre cohort of patients with symptomatic large volume lymphatic leaks.

Methods

Multicentre retrospective study of all lymphatic interventions performed between 2017–2023 in patients with large volume lymphatic leaks (> 500 ml a day). Intranodal lymphangiography was performed initially with technical success defined as opacification of the lymphatics at the aortic bifurcation and demonstration of lymphatic leak on the index ILAG procedure or immediate post procedural CT was recorded. Lymphatic embolisation was performed with a combination of direct puncture or transvenous cannulation with glue and or coil embolisation of the thoracic duct or leak point and in cases with refractory leak. Clinical success was defined as reduction in drain output to less than 20 mL per 24 h, or no further insensible lymph leak. Time to clinical success after ILAG and adjunctive embolisation was recorded.

Results

ILAG alone lead to clinical success in 14 of 32 (44%) patients after a median of 14 days. Subsequent embolisation was performed in 12 refractory cases; this was successful in 8 (67%) at median of 8 days. Overall clinical success of all lymphatic interventions was 69% (22 of 32 patients) at a median of 11 days (IQR 5–34). No statistically significant correlation between the site of leakage, aetiology or embolisation technique correlated with clinical success. Decision to proceed to repeat ILAG or an adjunct procedure was made on a clinical basis, following multidisciplinary discussion.

Conclusions

ILAG can be employed a first line interventional therapeutic technique to treat clinically significant lymphatic leaks that are refractory to conservative and medical management. Adjunctive procedures, including embolisation, can be considered as part of clinical decision making after a period of 1–2 weeks’ watchful waiting in continuingly refractory cases.
Percutaneous transhepatic arterial access for coil embolization of hepatic artery infusion pump-associated bleeding
Authors: Dutta Anuj K. , Shankar Vishal , Santos Ernesto G. , Marinelli Brett , Alexander Erica S. , Sotirchos Vlasios S. , Zhao Ken
Published: January 2025

Background

Hepatic artery infusion pump (HAIP) chemotherapy is a locoregional treatment for intrahepatic malignancies. HAIPs are surgically implanted, and the catheter tip is typically inserted into a ligated gastroduodenal artery stump. Potential complications at the catheter insertion site include dehiscence, pseudoaneurysm or extravasation, and adjacent hepatic arterial stenosis and thrombosis. Bleeding complications can be treated with stent-graft placement or coil embolization across the injury site, typically with standard antegrade arterial approach into the hepatic arterial system by transfemoral or transradial access. However, in cases where an antegrade approach is not possible, alternative methods are necessary.

Case presentation

A patient presented with an enlarging hematoma due to bleeding at the gastroduodenal artery HAIP catheter insertion site. Emergent angiography revealed concomitant common hepatic artery occlusion and retrograde perfusion of the GDA via tortuous, diminutive hepatic collaterals which precluded standard antegrade approach. Collateral inflow from the dorsal pancreatic artery was utilized to opacify the right hepatic artery. The segment 5 hepatic artery was percutaneously accessed under fluoroscopic guidance, and microcoils were deployed both proximal and distal to origin of the gastroduodenal artery. The patient remained stable throughout the postoperative period and was discharged after an otherwise uneventful admission. Follow-up computed tomography demonstrated resolution of the hematoma and no bleeding or biliary complication from transhepatic access.

Conclusions

This report highlights the safety and efficacy of percutaneous transhepatic arterial access for endovascular management of HAIP associated bleeding at the gastroduodenal artery when standard antegrade interventions cannot be performed. Interventional radiologists caring for patients with HAIPs should be familiar with their potential complications and the range of techniques required for management.
Managing cotton canopy architecture for machine picking cotton via high plant density and plant growth retardants
Authors: Lakshmanan Sankar , Somasundaram Selvaraj , Shri Rangasami Silambiah , Anantharaju Pokkharu , Vijayalakshmi Dhashnamurthi , Ragavan Thiruvengadam , Dhamodharan Paramasivam
Published: January 2025

Machine picking in cotton is an emerging practice in India, to solve the problems of labour shortages and production costs increasing. Cotton production has been declining in recent years; however, the high density planting system (HDPS) offers a viable method to enhance productivity by increasing plant populations per unit area, optimizing resource utilization, and facilitating machine picking. Cotton is an indeterminate plant that produce excessive vegetative growth in favorable soil fertility and moisture conditions, which posing challenges for efficient machine picking. To address this issue, the application of plant growth retardants (PGRs) is essential for controlling canopy architecture. PGRs reduce internode elongation, promote regulated branching, and increase plant compactness, making cotton plants better suited for machine picking. PGRs application also optimizes photosynthates distribution between vegetative and reproductive growth, resulting in higher yields and improved fibre quality. The integration of HDPS and PGRs applications results in an optimal plant architecture for improving machine picking efficiency. However, the success of this integration is determined by some factors, including cotton variety, environmental conditions, and geographical variations. These approaches not only address yield stagnation and labour shortages but also help to establish more effective and sustainable cotton farming practices, resulting in higher cotton productivity.
A comparative study of hybrid adaptive neuro-fuzzy inference systems to predict the unconfined compressive strength of rocks
Authors: Cao Wei
Published: January 2025

The accurate prediction of unconfined compressive strength (UCS) in rock samples is critical for the successful planning, design, and implementation of mining and civil engineering projects. UCS is crucial in assessing the stability and durability of rock masses, which directly influences the safety, efficiency, and cost-effectiveness of construction and excavation operations. Here’s a refined version of your text for enhanced clarity and flow: in this part, the execution of the proposed model was compared for both single and hybrid configurations. Hybrid models included support vector regression (SVR) combined with the Seahorse Optimizer (SVSH) and SVR combined with the COOT optimization algorithm (SVCO). For training, 70% of the UCS dataset was utilized, while the remaining 30% was equally divided between testing (15%) and validation (15%). For the model evaluation, several metrics were considered in this work, including the R2, RMSE, WAPE, MAE, and RAE, which ensure fairness in the analysis. The closer the R2 value comes to 1, the better the performance. The error metrics should be close to 0 for better accuracy. From Table 2, one can observe that the result of the standalone SVR model gave an RMSE of 6.213 during training and 9.454 during testing, hence showing poor performance. However, the inclusion of optimization algorithms significantly improved the performance of the SVR framework. Among the hybrid models, the SVSH model had the best performance, with an R2 value of 0.998 and an RMSE of 1.261 during training. The SVCO model performed moderately, with an R2 value of 0.988 during training.
High Prevalence of Malnutrition in Geriatric Patients With Solid Organ Cancer—An Institutional Study
Authors: Shriwastav Ujjawal Kumar , Sundriyal Deepak , Khanna Mridul , Sunny Neethu , Sehrawat Amit , Dhar Minakshi
Published: January 2025

PURPOSE

The demographic transition toward aging heralds an increase in the number of geriatric patients with cancer in India. Comprehensive geriatric assessment (CGA) is a sine qua non for treatment planning and shared decision making in these patients. We aimed to study the prevalence of malnutrition and the associated risk factors in geriatric patients with solid organ cancer.

METHODS

In this observational study, treatment-naïve geriatric patients with cancer underwent CGA. We performed a Mini Nutritional Assessment (MNA) to diagnose malnutrition. Data analysis was done using descriptive statistics, Pearson’s chi-square, Spearman correlation, and multivariable regression analysis to assess the factors associated with malnutrition.

RESULTS

One hundred forty-two patients were included in the analysis. The median age was 67 (range, 60-88) years, with a male preponderance of 73.2% (n = 104) and a stage IV disease of 75.4% (n = 107). Most patients, 91.6% (n = 130), had abnormal MNA scores. Nearly one third of the patients, 35.2% (n = 50), were underweight (BMI <18.5 kg/m
2
). Poor performance status (PS) was seen in 66.2% (n = 94) of the patients. Poor appetite 79.6% (n = 113) was the most common risk factor, followed by addictions (74.6%, n = 106), chronic constipation (35.9%, n = 51), and polypharmacy (21.8%, n = 31). Cognitive impairment and depression were seen in 35.2% (n = 50) and 57.1% (n = 81) of the patients, respectively. The study found a significant correlation of MNA with age (
P
= .048), depression (
P
< .001), PS (
P
< .001), functional decline (
P
< .001), and cognition (
P
< .001).

CONCLUSION

There exists a widespread prevalence of malnutrition and amenable risk factors in geriatric patients with cancer. Nutritional assessment is essential, and interventions should be implemented to improve clinical outcomes.
Development of a genetically tailored implantation hepatocellular carcinoma model in Oncopigs by somatic cell CRISPR editing
Authors: Elkhadragy Lobna , Carlino Maximillian J. , Jordan Luke R. , Pennix Thomas , Ismail Nahed , Guzman Grace , Samuelson Jonathan P. , Schook Lawrence B. , Schachtschneider Kyle M. , Gaba Ron C.
Published: January 2025

Hepatocellular carcinoma (HCC) is an aggressive disease with poor prognosis, necessitating preclinical models for evaluating novel therapies. Large-animal models are particularly valuable for assessing locoregional therapies, which are widely employed across HCC stages. This study aimed to develop a large-animal HCC model with tailored tumor mutations. The Oncopig, a genetically engineered pig with inducible TP53R167H and KRASG12D, was used in the study. Hepatocytes were isolated from Oncopigs and exposed to Cre recombinase in vitro to create HCC cells, and additional mutations were introduced by CRISPR/Cas9 knockout of PTEN and CDKN2A. These edits increased Oncopig HCC cell proliferation and migration. Autologous HCC cells with these CRISPR edits were implanted into Oncopigs using two approaches: ultrasound-guided percutaneous liver injections, which resulted in the development of localized intrahepatic masses, and portal vein injections, which led to multifocal tumors that regressed over time. Tumors developed by both approaches harbored PTEN and CDKN2A knockout mutations. This study demonstrates the feasibility of developing genetically tailored HCC tumors in Oncopigs using somatic cell CRISPR editing and autologous implantation, providing a valuable large-animal model for in vivo therapeutic assessment.
Pastoralism in context
Authors: Φιλιόγλου Δημήτριος
Published: January 2025

Η κτηνοτροφία και η γεωργία υπήρξαν, πέραν πάσης αμφιβολίας, η ραχοκοκαλιά της αρχαίας ελληνικής οικονομίας. Τα βοοειδή, τα πρόβατα, οι αίγες και οι χοίροι, κατά κύριο λόγο, τροφοδοτούσαν τις δραστηριότητες του οίκου, της αγοράς και της λατρείας με τα πρωτογενή και δευτερογενή προϊόντα τους, αποτελώντας ένα ζωτικής σημασίας μέρος της καθημερινής ζωής. Ωστόσο, οι ιστορικοί και οι αρχαιολόγοι διχογνωμούν, εδώ και δεκαετίες, ως προς την κλίμακα και τον βαθμό εξειδίκευσης της κτηνοτροφίας. Οι γραπτές πηγές είναι αποσπασματικές και ενίοτε μονομερείς, καθώς αφορούν τις μορφωμένες ανώτερες τάξεις των αστικών κέντρων, ενώ τα (ζωο)αρχαιολογικά δεδομένα που έχουν μελετηθεί μέχρι στιγμής προέρχονται κατά βάση από τελετουργικά συγκείμενα και είναι άμεσα συσχετιζόμενα με την λατρεία. Ως αντιμετώπιση αυτών των προκλήσεων, η παρούσα μελέτη συνδυάζει μία ολοκληρωμένη προσέγγιση συνδυάζοντας καθιερωμένες ζωοαρχαιολογικές και καινοτόμες πολυ-ισοτοπικές (87Sr/86Sr, δ13C, δ18O) αναλύσεις για την κατανόηση του ρόλου της κτηνοτροφίας στις οικιακές οικονομίες. Η παρούσα διεπιστημονική μελέτη αναγνώρισε τόσο διαφορές όσο και ομοιότητες στην διαχείριση των ζώων μεταξύ των θέσεων της Μαγούλας Πλατανιώτικης, Νέας Άλου και Φερών, οικισμών διαφορετικής πολιτικής και οικονομικής ισχύος στην Θεσσαλία, κεντρική Ελλάδα κατά τη διάρκεια των ταραχωδών Κλασσικών και Ελληνιστικών Περιόδων (4ος-1ος αιώνας ΠΚΕ). Διαφοροποίηση εντός της κάθε θέσης ως προς τον βαθμό εξειδίκευσης και η απουσία παραγωγής σε μεγάλη κλίμακα, ανεξαρτήτως της σπουδαιότητας της κάθε θέσης αποκάλυψε ότι η συνεχής πολιτική αστάθεια εμπόδισε την σημαντική οικονομική ανάπτυξη. Σαν αποτέλεσμα, η κτηνοτροφία όφειλε να προσαρμοστεί και να στοχεύσει τις μικρές τοπικές αγορές παρά τις μεγαλύτερες αγορές των μεγάλων αστικών κέντρων εκείνης της περιόδου.
Evaluation der Hämostase mittels Rotationsthrombelastometrie (ROTEM®) bei Patienten mit akutem Leberversagen und fortgeschrittener Lebererkrankung
Authors: Μπέδρελη Σωτηρία
Published: January 2025

Οι ηπατικές νόσοι, όπως η οξεία ηπατική ανεπάρκεια και η ηπατική κίρρωση, χαρακτηρίζονται από περίπλοκες αιμοστασιολογικές διαταραχές. Σύμφωνα με τις συμβατικές μεθόδους ανάλυσης του πηκτικού μηχανισμού [International Normalized Ration (INR), χρόνος ενεργοποιημένης μερικής θρομβοπλαστίνης (aPTT), αριθμός αιμοπεταλίων, ινωδογόνο], αναμένεται στους ασθενείς αυτούς μία αιμορραγική διάθεση. Ωστόσο, μεγάλος αριθμός ασθενών με ηπατικές νόσους αναπτύσσουν θρομβοφιλική διάθεση με, εν μέρει, μοιραία κατάληξη. Παρόλα αυτά, η προεγχειρητική αξιολόγηση του πηκτικού μηχανισμού γίνεται με βάση αυτές τις συμβατικές μεθόδους ανάλυσης, με ανάλογη υποκατάσταση των ελλιπών παραγόντων πήξης. Η περιστροφική θρομβοελαστογραφία (ROTEM®) είναι μία μέθοδος ανάλυσης των ιξωδοελαστικών ιδιοτήτων του ολικού αίματος και θρόμβου παρά την κλίνη του ασθενούς. Στην παρούσα διδακτορική διατριβή συμπεριελήφθησαν ασθενείς με οξεία ηπατική ανεπάρκεια και ασθενείς με ηπατική κίρρωση, οι οποίοι είχαν προεπεμβατικά διαταραγμένο πηκτικό μηχανισμό, σύμφωνα με τις συμβατικές μεθόδους ανάλυσης και στους οποίους έγινε ανάλυση και προεγχειρητική αντικατάσταση των παραγόντων πήξης σύμφωνα με τη θρομβοελαστογραφία. Οι ασθενείς με οξεία ηπατική ανεπάρκεια παρουσίασαν στη θρομβοελαστογραφία ένα τυπικό προφίλ πήξης του αίματος, το οποίο παρουσίασε στατιστικά σημαντικές διαφορές από το προφίλ πήξης του αίματος των ασθενών με ηπατική κίρρωση. Η παρατήρηση αυτή έχει σημαντική κλινική σημασία και θα μπορούσε, ενδεχομένως, να συνεισφέρει στο διαχωρισμό αυτών των δύο κλινικών οντοτήτων. Στους ασθενείς με οξεία ηπατική ανεπάρκεια δεν χρειάστηκε σύμφωνα με τη θρομβοελαστογραφία καμία προεπεμβατική υποκατάσταση παραγόντων πήξης. Στους ασθενείς με κίρρωση του ήπατος και INR > 1,5 χρειάστηκε σύμφωνα με τη θρομβοελαστογραφία περισσότερο ινωδογόνο και λιγότερο προθρομβινικό σύμπλεγμα (Prothrombin Complex Concentrate, PCC) σε σχέση με την υποκατάσταση των παραγόντων πήξης βασισμένη στις συμβατικές μεθόδους ανάλυσης της ομάδας μάρτυρα. Εκτός αυτού, απεφεύχθη η υποκατάσταση πρόσφατα κατεψυγμένου πλάσματος (Fresh Frozen Plasma, FFP). Οι ασθενείς με ηπατική κίρρωση και θρομβοπενία έλαβαν σημαντικά λιγότερες μονάδες αιμοπεταλίων σύμφωνα με τη θρομβοελαστογραφία σε σχέση με αυτές που θα λάμβαναν σύμφωνα με τις συμβατικές μεθόδους ανάλυσης του πηκτικού μηχανισμού. Συνολικά, η θρομβοελαστογραφία συνέβαλε στη σημαντική μείωση των μεταγγίσεων παραγόντων πήξης χωρίς να παρατηρηθεί αύξηση στις αιμορραγικές επιπλοκές. Επιπλέον, κατέστη δυνατή η ελάττωση των άμεσων και απώτερων επιπλοκών των μεταγγίσεων, όπως επίσης και των συνολικών δαπανών.
Η διττή διάσταση της ανθρώπινης οντότητας
Authors: Ράγια Θωμαή
Published: January 2025

Η ανά χείρας διδακτορική διατριβή έχει ως αντικείμενο μελέτης τη διττή διάσταση της ανθρώπινης οντότητας, η οποία εκδιπλώνεται ως υπαρκτική ολότητα εν μέσω ενδοκοσμικών φαινομένων και τις ψυχοσωματικές συνέπειες των τροπικοτήτων και εκτροπών της εκδίπλωσης αυτής εντός του hic et nunc. Βασικοί στόχοι της παρούσας μελέτης είναι: : η ανάδειξη της φιλοσοφίας ως αναίρεσης του αναγωγισμού μέσα από τη διαλεκτική πλευρά, έστω και διαλεκτικά ψήγματα κάθε στοχαστή και η προσέγγιση της θεραπευτικής διάστασης της φιλοσοφίας μέσα από την εστίαση στις τροπικότητες του βιωμένου σώματος, το οποίο εκτείνεται ως ενδιαμεσότητα φυσικού- ανθρώπινου. Η διττότητα της ανθρώπινης φύσης αποκαλύπτεται μέσα από τις έννοιες ψυχή, νους, εγκέφαλος, μέσα από το άυλο- υλικό υπαρκτικό γίγνεσθαι, μέσα από τα συναισθήματα, τα πάθη, τη διαίσθηση και τη βούληση που συνθέτουν τόσο το ατομικό, όσο και το συλλογικό φαντασιακό, το οποίο κινείται συγχρόνως με ολόκληρο το σώμα. Σε αυτό το σημείο αναδεικνύεται η αλληλενέργεια νοητικότητας- σωματικότητας, ο τρόπος, δηλαδή, με τον οποίο η ιδέα οδηγεί στην πρόκληση σωματικών συμπτωμάτων, ιδίως εντός της σύγχρονης κοινωνικοπολιτικής απρόβλεπτης πραγματικότητας. Πριν από κάποιες δεκαετίες πολλοί επιστήμονες, ιδίως από τον χώρο της ιατρικής, θα αντιμετώπιζαν με καχυποψία τη θεωρία σύνδεσης νου- σώματος. Η ανάπτυξη της Φαινομενολογίας και η μετεξέλιξή της σε νευρο-φαινομενολογία, έφερε στο προσκήνιο την ανθρώπινη σωματικότητα ως leib εναίσθησης. Οι ψυχοφυσικές αντιδράσεις που μεταβάλλουν την κατάσταση της ανθρώπινης σωματικότητας ως –άνευ όρων- ανοιχτότητας θα μπορούσε να αναλυθεί με τους όρους του Γάλλου μαθηματικού και φιλοσόφου, René Thom, και πιο συγκεκριμένα με αυτόν τον όρο των «καταστροφών». Η θεωρία των «καταστροφών» εμπνέεται τόσο από το ηρακλείτειο αεικίνητο γίγνεσθαι, όσο και από το σταθερό, αλλά όχι στάσιμο, παρμενίδειο Είναι. Σύμφωνα με τον René Thom ο όρος «καταστροφή» εκφράζει κάθε βίαιη ρήξη, η οποία πολλές φορές, επιτρέπει σε ένα σύστημα να επιζήσει. Πρόκειται για έναν «ελιγμό επιβίωσης» ενός συστήματος που εγκαταλείπει την ομαλή του χαρακτηριστική εντός μίας χωροχρονικότητας η οποία χαρακτηρίζεται από το τριπλό της Διακύβευσης, του Απροσδόκητου και της Περιπλοκότητας. Η ανθρώπινη ύπαρξη διάγει το βίο της υπό συνθήκες βιαιότητας, πολέμου, σκληρότητας, φαινόμενα θλιβερής καθολικότητας και εργαλειοποιημένου θανάτου, σώματος και ψυχής. Μέσα σε αυτό το χάος ο άνθρωπος μοιάζει να τίθεται εκ ποδών σαν να πρόκειται για παράπλευρη απώλεια. Σήμερα λοιπόν το διακύβευμα είναι: Να αναλάβει ο άνθρωπος από το μηδέν τη σχέση του με το ζην, όμως πώς μπορεί να κατορθωθεί αυτό σε μία πραγματικότητα κατά την οποία ο άνθρωπος αποστρέφεται το ανθρώπινο; Πώς λοιπόν, μπορεί το ανθρώπινο να προστατευτεί από τους ανθρώπους, ιδίως στη σύγχρονη εποχή του μετα-ανθρώπινου;
Validating the underpinnings of water corticosterone measurement for aquatic amphibians
Authors: Smith Tessa E , Holmes Andrew M , Emmans Christopher J , Coleman Robert , Hosie Charlotte A
Published: January 2025

Background Good animal welfare is important ethically but also to ensure animals provide valid scientific models. Despite thousands of amphibians in research laboratories there is minimal quantitative evidence pertaining to their management and welfare. This study validated methods to non-invasively measure corticosterone, the amphibian ‘stress’ hormone, from tank water to provide a robust and reliable welfare assessment tool. Methods We report experiments (A) that evaluate parameters linked to the performance of our biochemical extraction methods for waterborne corticosterone and, importantly, associated sampling procedures. We evaluate appropriate sampling water type, sampling vessel, filtration methods, potential degradation of waterborne corticosterone over time and the impact of sampling procedures on animal corticosterone levels. We wanted to determine sampling parameters that yielded the least background corticosterone and had minimum negative impact on the animals. The second series of experiments (B) evaluated parameters linked to the biology of Xenopus, including the influence of circadian rhythm, sex and snout-vent length on waterborne corticosterone levels, since fundamental knowledge of a species’ biology is essential for designing robust experiments and in the interpretation of the results. Results We propose collecting corticosterone samples in deionised water in either plastic or glass containers. The filtering process does not impact the amount of corticosterone measured in the water sample. Levels of corticosterone collected in the water change over a 48-hr period so we advocate standardising time from hormone collection to storage at - 20 °C. Repeated transfer of frogs to sampling containers does not increase corticosterone, suggesting our methods are not cumulatively stressful. Corticosterone levels were not impacted by circadian phase, sex or snout-vent length. Conclusion We have developed and validated robust methods to quantify waterborne corticosterone. We hope they provide a template for researchers wishing to develop methods to measure waterborne corticosterone in aquatic amphibians.
Mapping evidence on screening for Primary Open Angle Glaucoma (POAG) at primary health care level: A scoping review protocol
Authors: Mkhabela Portia Noxolo , Magakwe Tshubelela Sello Simon , Nkambule Sphamandla Josias , Xulu-Kasaba Zamadonda Nokuthula
Published: January 2025

Background Glaucoma, the primary cause of irreversible blindness globally, mainly presents as primary open-angle glaucoma and is more common in sub-Saharan Africa. This chronic disease of the optic nerve often goes undiagnosed due to its asymptomatic early stages. Increased awareness and regular eye exams can help in early detection and management. Purpose/Objectives This study aims to comprehensively identify the existing literature on screening programs or interventions for primary open-angle glaucoma (POAG) at the primary healthcare level. Additionally, the study aims to outline the characteristics of these screening programs/interventions and emphasize the most successful programs that have been implemented at the primary healthcare level. Methods The scoping review will be conducted following the framework developed by Arksey and O’Malley and Levac et al. (2010) methodological enhancement for conducting a scoping review project. The search will cover peer-reviewed articles published in English between the inception and May 2024 from databases such as PubMed, Google Scholar, Science Direct, EBSCOhost, Web of Science, and the WHO Global Database. The search on the EBSCOhost platform will include databases such as Academic Search Complete, APA PsycInfo, Health Source-Consumer Edition, Health Source: Nursing/Academic Edition, MEDLINE with full text, and Open Dissertations. The extracted data will be analyzed using QualCoder 1.9 version. The study findings will be reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR), and a checklist will be completed to ensure adherence to reporting guidelines. Conclusion This review will help identify research gaps in primary healthcare POAG screening programs and recommend effective interventions.
CHRONIC LYMPHOCYTIC LEUKEMIA: GENERAL IDEAS, ILLUSTRATION BY CLINICAL OBSERVATION
Authors: Marfina E.
Published: January 2025

Chronic lymphocytic leukemia is one of the most common types of leukemia. Chronic lymphocytic leukemia is more common in men, the ratio of men and women who become ill is 2:1. Infectious complications are the main cause of death in patients with CLL. Mortality from infections is 30-50% of all fatal cases. Despite significant progress in therapy, CLL remains an incurable disease. The current goal of treatment is to increase the proportion of overall survival and progression-free survival with minimal toxicity. A clinical observation of a patient with chronic lymphocytic leukemia and a good response to therapy according to the RFC scheme is presented.
BEHCETS DISEASE IN THE PRACTICE OF AN INTERNAL DOCTOR
Authors: Prohorov P.
Published: January 2025

Behcet's disease is a systemic vasculitis of unknown etiology, a number of clinical manifestations of which are associated with the immune response mediated by T cells. Due to the polysyndromic nature of the disease, multidisciplinary interaction of doctors in a multidisciplinary team is necessary in the diagnosis and treatment of the disease to ensure early diagnosis and the greatest effectiveness of therapy.
WAYS TO IMPROVE THE EFFECTIVENESS OF SURGICAL TREATMENT OF NON-PALPABLE BREAST FORMATIONS (literature review)
Authors: Guseynov Arif , Fedorischev V. , Guseynov T. , Murav'eva S.
Published: January 2025

Due to the progress of modern imaging methods, the number of detected non-palpable focal breast formations, including small nodular cancer and in situ cancer, has increased significantly.
Surgical treatment of non-palpable breast formations is aimed at their removal in order to clarify the nature of the pathology.
In clinical practice, interventions in the volume of sectoral breast resection and vacuum aspiration biopsy (VAB) are performed for this purpose.
During resection operations, preoperative marking of the formation is necessary to increase the effectiveness of the operation and eliminate the situation when the formation or part of it is not removed.
The standard for preoperative marking is the installation of a wire needle inside the formation under the supervision of ultrasound, X-ray mammography (RMG) or magnetic resonance imaging (MRI), followed by resection of the breast area together with the needle.
In recent years, due to the disadvantages of the wire method, there has been a transition to the use of wireless technologies.
The simplest and most accessible method is skin labeling after imaging of the formation with ultrasound or RMG.
The use of coloring agents, in particular methylene blue, indocyanine green, charcoal suspension is the optimal method due to its high efficiency at low cost.
The use of methods of radioactive labels (RSL and ROLL), magnetic and paramagnetic labels, localization using the radar reflector RRL, represent new effective approaches in the localization of non-palpable breast formation.
Intraoperative ultrasound is a highly effective method of localization of non-palpable breast formations, but requires compliance with the conditions of intraoperative ultrasound and the involvement of an ultrasound diagnostic doctor in the operation.
VAB has an advantage over sectoral resection due to the accurate visualization of the formation under ultrasound before and during surgery, which ensures complete removal of the formation.
The use of VAB is limited by the mandatory imaging of education during ultrasound and the lack of necessary equipment in many large multidisciplinary medical institutions.
What should every doctor know about ocular melanoma? - review of literature
Authors: Grzegorczyk Aleksandra , Pachla Magdalena , Mazur Ewa
Published: January 2025

The following paper aims to discuss melanoma located in the eye. Melanoma is a malignant tumor arising from melanocytes, in which a mutation has occurred in the DNA and pathological cells have developed. In most cases, this tumor is located on the skin exposed to sunlight, but it is also rarely located in the structures of the eye, especially in the part called uvea. It consists of the anterior and posterior parts, and in each of them the process of carcinogenesis can occur. The disease can cause very non-specific symptoms, mainly pain, visual disturbances, floaters and photopsia, or exophthalmos, but almost half of the cases are asymptomatic. Treatment is complicated and depends on many factors, radiation therapy, laser therapy, local resection and enucleation are used. Most patients are diagnosed when the changes are already extensive, or metastases occur. In the case of liver metastases, the prognosis is unfavorable. For this reason, we want every doctor to pay attention to the eye symptoms reported by the patient in order to be able to recognize this disease as soon as possible and treat it effectively.
Periodismo televisivo en Brasil: nuevas prácticas y procesos de producción después de la pandemia de COVID-19.
Authors: Teixeira de Faria Pereira Gustavo
Published: January 2025

El objetivo de este estudio es observar los cambios ocurridos en el ámbito del periodismo televisivo brasileño en el escenario después de la pandemia del COVID-19. La investigación adoptó
como abordaje metodológico el análisis documental, tal como lo describe Gil (2008), posibilitando la identificación de las modificaciones en el periodismo televisivo en el contexto de la pandemia y, adicionalmente, se utilizó el análisis de materialidad audiovisual, propuesto por Coutinho
(2016; 2018), a través de la investigación de cinco ediciones de dos programas informativos emitidos por Rede Globo, destacada como la principal estación de televisión de Brasil: Jornal Nacional,
el principal y más antiguo noticiero de Globo, y MG1, un noticiero local del estado de Minas Gerais,
elegido porque se inserta en un contexto más regional y que se caracteriza por la proximidad a
los ciudadanos, como ocurre con otros noticieros locales de Rede Globo. El periodo delimitado
para el análisis comprende la semana del 8 al 13 de mayo de 2023, representando la primera semana tras la declaración oficial del fin de la pandemia por parte de la Organización Mundial de
la Salud (OMS). Los resultados preliminares indican una serie de transformaciones que fueron
asimiladas durante el período de pandemia –como se puede observar en otros estudios sobre el
tema– y que continúan influyendo en el escenario del periodismo televisivo brasileño después
del COVID-19, integrándose como elementos constitutivos de la noticia televisiva.
El uso de la Inteligencia Artificial en el sector del marketing, la publicidad y los contenidos de marca en España.
Authors: Asenjo-McCabe Susana , del Pino-Romero Cristina
Published: January 2025

Esta investigación parte de un análisis de la literatura académica o scoping review (Codina 2021)
sobre inteligencia artificial (IA) aplicada al marketing y la publicidad. Tras esta contextualización,
se ha empleado la metodología de encuesta a una muestra exploratoria formada por profesionales de marketing, comunicación y publicidad de España, con la que se ha obtenido un total
de 372 respuestas. El objetivo ha sido explorar los beneficios del uso de la IA en la optimización
de campañas, conocer la percepción de los publicitarios sobre esta realidad, y, de esta manera,
poder identificar los nuevos retos que este escenario implica, con la consecuente expectación
frente al universo de oportunidades que la IA supone. Los resultados revelan el papel central de
la IA en la agilización de procesos, su uso en la investigación de mercados para identificar tendencias y patrones, así como nuevos recursos y ahorro de tiempo en el sector publicitario. Como
conclusión general, la investigación incide en el abanico de posibilidades que está aún por explorar y que abarca desde la suscripción de las empresas a las herramientas de IA de pago hasta el
planteamiento de estas hacia las consideraciones éticas y morales, así como la incorporación de
valores y creencias humanos en los algoritmos. La continua investigación acerca de cómo se usa
la IA resulta ser esencial para mantener la relevancia y sostenibilidad de la empresa publicitaria
en este entorno dinámico y digital.
Programa “Cogito Ergo Sum” en las habilidades para la vida en una institución educativa de Santa Clara Lima, Ate-Perú.
Authors: Romero Vela Sonia Lidia , Lescano López Galia Susana , Cueva Vergara Gloria Luz , Narvaste Bertha Silva , Godoy Caso Juan
Published: January 2025

La globalización ha generado problemas de manera transversal en
todos los ámbitos como son el social, cultural, político, educativo, etc. Y este
último trae consigo crisis y riesgos en la niñez y adolescencia, aparecen cuestiones
sobre su existencia, sexualidad, identidad, motivaciones y otros. El objetivo del
estudio es evaluar la eficiencia del Programa “cogito ergo sum” en las habilidades
para la vida en adolescentes de secundaria. Por tanto, se empleó un diseño mixto,
cuantitativo porque se usó el diseño cuasi experimental, con un grupo control y un
grupo experimental y cualitativo para el análisis hermenéutico-fenomenológico.
Se observó que ambos grupos fueron equivalentes al inicio. Luego de la aplicación
del programa, se halló que en el grupo control ya no se encontraban estudiantes en
el nivel de inicio, el 77.8% se encontraban en proceso y el 22.2% en un nivel
logrado. El grupo experimental presentó un 40.7% en el nivel de proceso y
logrado. Con un 18.5% en el nivel destacado. Un adolescente que cuestione,
reflexione y tome conciencia de sí mismo ejercerá un pensamiento autónomo y
multidimensional, además de ello puede contribuir con su entorno y podrá tomar
decisiones asertivas para la transformación de sí y la sociedad. Se concluye que
existe eficiencia en el grupo experimental en habilidades para la vida luego de
aplicar el programa Cogito Ergo Sum en adolescentes, con un resultado de Sig.
.023 menor a p<0.05
La justicia y el proceso penal en clave algorítmica. Nuevos enfoques, nuevos riesgos.
Authors: Pereira Puigvert Sílvia
Published: January 2025

De los múltiples aspectos con que se puede abordar la inteligencia artificial (en adelante, IA), este artículo se sustenta en una breve panorámica sobre la digitalización del proceso penal y la justicia predictiva y sus
riesgos. Porque se habla de predicciones algorítmicas e IA predictiva
como la gran estrella emergente. Las predicciones algorítmicas se van
perfeccionando y vivimos en una era digital, inmersos en una máquina
digital. La revolución informática, que comenzó a finales del siglo pasado, se ha desbocado con la creciente potencia de los ordenadores y los
métodos de aprendizaje profundo que engullen el imparable aumento
de datos y nutren los algoritmos predictivos. Y los retos o desafíos son
múltiples. Ya hay muchas alertas: se empezó por troyanos y piratas informáticos, pero ahora existen prácticas preocupantes de adquisición
de datos por reconocimiento facial, por ejemplo. En las próximas líneas,
intentaremos dar cabida a todas estas cuestiones.
La inteligencia artificial en el proceso penal: eficiencia versus garantías.
Authors: Yáñez García-Bernalt Irene
Published: January 2025

La incorporación de la Inteligencia Artificial (IA) al proceso penal genera tensiones entre la eficiencia judicial y el respeto de las garantías
y derechos procesales fundamentales. La IA puede acelerar, sin duda,
la tramitación del processo, mejorar la gestión y ofrecer herramientas
predictivas destinadas a apoyar las decisions. No obstante, plantea serios riesgos como la Vulneración del derecho de defensa, la igualdad,
la presunción de Inocencia y la protección de los datos personales,
debido a los posibles sesgos y errores algorítmicos. Para garantizar
un processo con todas las garantías será crucial implementar mecanismos de supervisión humana, transparencia y explicabilidad. El uso
ético, legal y garantista se erige como esencial para mantener el equilibrio entre un proceso penal garantista y las tecnologías
La construcción de un algoritmo «ético».
Authors: Castagnedi Ramirez Alessandra Esther
Published: January 2025

El artículo aborda la ética en la inteligencia artificial (IA), destacando el
riesgo de sesgos discriminatorios en los algoritmos que afectan decisiones cruciales, como la aprobación de hipotecas o la asignación de
atención médica. A partir de 2016, se incrementó la participación de
gobiernos y organizaciones en el debate sobre la creación de IA ética
y justa. Ejemplos de sesgos algorítmicos ilustran problemas de racismo y exclusión, donde algoritmos, incluso sin información explícita
de raza o género, perpetúan inequidades sociales. Además, se analiza la necesidad de transparencia y “explicabilidad en los sistemas de
IA para asegurar decisiones comprensibles y auditables. Propone un
marco legal europeo que garantice la equidad y minimice los sesgos,
sugiriendo certificaciones y una estricta regulación en sistemas de
alto riesgo, señalando que la ética debe ser integrada en el diseño y
aplicación de estas tecnologías para evitar abusos y discriminaciones
Neuroimagen y responsabilidad penal. Perspectivas y desafíos.
Authors: Mallorqui-Ruscalleda Enric
Published: January 2025

Este artículo analiza el uso de la neuroimagen en la evaluación de la
responsabilidad penal, destacando sus perspectivas y desafíos en el
ámbito legal. Se exploran técnicas avanzadas como la resonancia magnética (MRI) y la resonancia magnética funcional (fMRI), enfocándose en
su capacidad para mapear el cerebro y evaluar la mens rea (intención
criminal) y la conciencia durante la comisión de delitos. El trabajo se
divide en secciones que abarcan la interpretación de conceptos legales
mediante neuroimagen, los dilemas éticos y prácticos asociados, y las limitaciones técnicas de estas tecnologías. Además, se discute la relevancia de la neuroimagen en casos penales, evaluando su impacto en la jurisprudencia y la necesidad de una integración cuidadosa y ética en los
procesos judiciales. Este enfoque interdisciplinario busca promover una
justicia penal más informada y equitativa, considerando tanto los avances tecnológicos como los derechos fundamentales de los individuos.
Los "Palazzi di Genova" de Rubens y la arquitectura de Alessi.
Authors: Pizzigoni Vittorio
Published: January 2025

Palazzi di Genova è, per molti versi, un libro doppio, quasi un libro che ne contiene due.
Innanzitutto, è il prodotto di due edizioni, una prima del 1622 e una seconda ampliata. Inoltre,
il libro contiene due tipi di rappresentazioni dei palazzi genovesi: un primo tipo, più preciso, con
molte piante, sezioni e prospetti, ma senza indicazione della proprietà dei palazzi; un secondo
tipo, meno preciso, spesso ridotto a un prospetto e due piante, ma con i nomi dei proprietari.
Palazzi di Genova sono un libro complesso e anomalo: si inserisce inevitabilmente tra i trattati di
architettura per argomento, ma se ne differenzia sia perché è costituito quasi esclusivamente da
disegni, sia perché sono tutti disegni di edifici contemporanei e di un'unica città; è un libro di
architettura realizzato da un pittore; inoltre, utilizza solo proiezioni ortogonali senza nemmeno
una prospettiva; infine, sebbene Peter Paul Rubens ne sia l'autore implicito, il suo nome non
compare sul frontespizio. Le particolarità dei Palazzi di Genova sono alla base sia del fascino che
degli interrogativi sollevati da questo libro. Questo saggio parte dalla rilettura della bibliografia
esistente per comprendere le acquisizioni consolidate e ipotizzare nuovi percorsi di ricerca sulle
questioni rimaste aperte. Infine, si concentra sui disegni preparatori della prima parte dell'opera,
in cui si propone di riconoscere le idee architettoniche derivate dal lavoro di Galeazzo Alessi.
Arquitectura y arquitectos en el Instituto Nacional de Industrial (INI).
Authors: García Rafael
Published: January 2025

Especialmente en los primeros treinta y cinco años, el periodo correspondiente a sus etapas
autárquica y desarrollista, el Instituto Nacional de Industria (INI) desarrolló una extensa actividad
constructiva acorde a sus ambiciosos programas industriales. Su promoción corrió a cargo tanto
del Instituto como entidad propia, como también en forma independiente, por las empresas
participadas. En dicha actividad la arquitectura tuvo un papel de importancia y reconocimiento
creciente, llegando a formarse un grupo de arquitectos estrechamente vinculados con el INI que
trabajaron dentro de él en o!cinas técnicas diferenciadas. En este artículo se analiza el carácter de
dichas colaboraciones a la vez que se ofrece una visión panorámica de la obra por ellos realizada.
No obstante, y por la actividad muchas veces autónoma de las empresas constituyentes del grupo,
la visión de conjunto se ha extendido también a los trabajos realizados por otros arquitectos con
encargos directos de dichas empresas. Por el gran número de entidades empresariales incluidas en
el holding del INI, el listado completo de dichas obras y arquitectos aún es provisional. Por otra
parte, la posible existencia de una arquitectura del INI estaría en realidad formada por un amplio
abanico de realizaciones girando en torno a un tronco común industrial, pero extendida a una
variada periferia de temas que, como la vivienda, la administración o los servicios, constituyeron
un complemento necesario. El carácter ideológico que pudo tener dicha arquitectura, su posible
manifestación en lo realizado y su evolución hacia la modernidad son cuestiones sobre las que
se re"exiona en la parte !nal del trabajo