bluuebunny/crossref_metadata_2025 huggingface dataset:
The embodiment of emotion-label words and emotion-laden words: Evidence from late Chinese–English bilinguals
Authors: Tang Dong , Fu Yang , Wang Huili , Liu Bo , Zang Anqi , Kärkkäinen Tommi
Published: March 2023

Although increasing studies have confirmed the distinction between emotion-label words (words directly label emotional states) and emotion-laden words (words evoke emotions through connotations), the existing evidence is inconclusive, and their embodiment is unknown. In the current study, the emotional categorization task was adopted to investigate whether these two types of emotion words are embodied by directly comparing how they are processed in individuals’ native language (L1) and the second language (L2) among late Chinese-English bilinguals. The results revealed that apart from L2 negative emotion-laden words, both types of emotion words in L1 and L2 produced significant emotion effects, with faster response times and/or higher accuracy rates. In addition, processing facilitation for emotion-label words over emotion-laden words was observed irrespective of language operation; a significant three-way interaction between the language, valence and emotion word type was noted. Taken together, this study suggested that the embodiment of emotion words is modulated by the emotion word type, and L2 negative emotion-laden words tend to be affectively disembodied. The disassociation between emotion-label and emotion-laden words is confirmed in both L1 and L2 and therefore, future emotion word research should take the emotion word type into account.
The magnitude of standard precautions practice and its associated factors among healthcare workers in governmental hospitals of northeastern Ethiopia
Authors: Keleb Awoke , Lingerew Mistir , Ademas Ayechew , Berihun Gete , Sisay Tadesse , Adane Metadel
Published: March 2023

Background

Non-compliance with infection control guidelines of healthcare workers may increase their risk of exposure to infectious diseases but can be prevented through adherence to standard precautionary practices in healthcare settings.

Objective

This study aimed to assess the magnitude of standard precautions practice and its associated factors among healthcare workers in government hospitals of South Wollo Zone, northeastern Ethiopia

Methods

An institutional-based cross-sectional study was conducted among 1,100 healthcare workers. Proportional sample size allocation for each selected government hospital was conducted followed by simple random sampling to select study participants using human resource records from each hospital. Data were collected using structured and self-administered pretested questionnaires. The data were analyzed using descriptive statistics, bivariable binary, and multivariable logistic regression models. Variables with a p-value <0.05 with a 95% CI were considered as having statistical significance

Results

The overall magnitude of compliance with standard precautions among healthcare workers was 19.2%. The result indicated that work experience of <5 years (AOR = 2.51; 95% CI: 1.07–5.89), absence of continuous water supply (AOR = 2.24; 95% CI: 1.95–5.29), and negative attitude (AOR = 2.37; 95% CI: 1.17–4.79) were significantly associated with poor compliance of standard precautions practice.

Conclusion

The overall magnitude of compliance with standard precautions among healthcare workers was low compared to the national magnitude of infection prevention practice. Interventions including consistent and effective training on infection prevention healthcare workers should be given regularly. Providing continuous water supply and building a positive attitude toward infection prevention practices among healthcare workers are also required.
Thoracic organ machine perfusion: A review of concepts with a focus on reconditioning therapies
Authors: Wagner Mitchell J. , Hatami Sanaz , Freed Darren H.
Published: March 2023

Thoracic organ transplantation, including lung, heart, and heart-lung transplants are highly regarded as gold standard treatments for patients suffering from heart failure or chronic end stage lung conditions. The relatively high prevalence of conditions necessitating thoracic organ transplants combined with the lack of available organs has resulted in many either dying or becoming too ill to receive a transplant while on the waiting list. There is a dire need to increase both the number of organs available and the utilization of such organs. Improved preservation techniques beyond static storage have shown great potential to lengthen the current period of viability of thoracic organs while outside the body, promising better utilization rates, increased donation distance, and improved matching of donors to recipients. Ex-situ organ perfusion (ESOP) can also make some novel therapeutic strategies viable, and the combination of the ESOP platform with such reconditioning therapies endeavors to better improve functional preservation of organs in addition to making more organs viable for transplantation. Given the abundance of clinical and pre-clinical studies surrounding reconditioning of thoracic organs in combination with ESOP, we summarize in this review important concepts and research regarding thoracic organ machine perfusion in combination with reconditioning therapies.
Using Application Usability Levels to support tracking the health of Heliophysics
Authors: Klenzing Jeff , Halford Alexa J. , Kellerman Adam , Thompson Barbara
Published: March 2023

The Application Usability Level (AUL) framework describes how a project advances from basic research to operation-ready applications. Here we expand upon the current project-level usage of Application Usability Levels into a programmatic usage which can be used to help funding agencies track the health of the Heliophysics program. Examples are discussed throughout Heliophysics to show the utility of the Application Usability Level framework for describing the usability level of projects.
Survival prediction among pathologic T4 bladder cancer patients following cytoreductive cystectomy: A retrospective single-center study
Authors: Bai Xuesong , Chen Guo , Shang Shihai , Li Senlin , Liu Huanrui , Feng Zhenwei , Gou Xin
Published: March 2023

Objectives

This retrospective study aimed to describe our institutional experience with cytoreductive cystectomy (Cx) in patients with pathological T4 (pT4) bladder cancer (BCa) and to investigate the clinicopathologic factors that can predict patient survival outcomes.

Methods

We reviewed the baseline demographics, clinicopathologic features, perioperative complications, and follow-up data of 44 patients who underwent Cx for pT4 BCa at our institution between 2013 and 2021. The Kaplan–Meier curve and the log-rank test were used to analyze progression-free survival (PFS) and overall survival (OS). Univariate and multivariate analyses were performed using the Cox regression model.

Results

The median age of the patients was 68 years [95% confidence interval (CI) 49–81]. Overall, 21 patients (47.7%) were estimated to have a high age-adjusted Charlson comorbidity index (ACCI) score (>4), and nine patients (20.5%) had pT4b substage BCa. None of the patients died of complications within 30–90 days after surgery. Severe complications occurred in 16% (n = 7) of patients within 30–90 days. During a median follow-up of 51 months, disease progression was detected in 25 patients (56.8%), and 29 patients (65.9%) died of any cause. The median PFS and OS were 15.0 and 21.0 months, respectively. The Kaplan–Meier analysis indicated that patients with high ACCI scores or pT4b BCa had worse PFS (P = 0.003 and P = 0.002, respectively) and OS (P = 0.016 and P = 0.034, respectively) than those with low ACCI scores or pT4a BCa. On multivariate analysis, pT4b substage [hazard ratio (HR), 4.166; 95% CI, 1.549–11.206; P = 0.005] and ACCI score >4 (HR, 2.329; 95% CI, 1.105–4.908; P = 0.026) remained independent risk factors for PFS and OS, respectively.

Conclusion

Our study revealed that the pT4b substage is associated with a poor prognosis and that the ACCI score is a relevant and practical method to evaluate survival outcomes in patients with pT4 BCa after Cx.
Outcomes following use of VersaWrap nerve protector in treatment of patients with recurrent compressive neuropathies
Authors: Hones Keegan M. , Nichols David Spencer , Barker Haley , Cox Elizabeth , Hones Jaime A. , Chim Harvey
Published: March 2023

Epineural scarring following previous carpal or cubital tunnel release can lead to pain and permanent dysfunction. To prevent this cascade, nerve wraps are an option. The purpose of this study was to evaluate outcomes following use of VersaWrap nerve protector during surgical decompression and neurolysis in patients with recurrent compressive neuropathies in the upper extremity. Twenty patients comprised the patient cohort, with a mean postoperative follow-up time of 139 days (range: 42–356 days). There were 13 females and 7 males, with a mean age of 43.4 years. Fourteen surgeries were performed for revision cubital tunnel, 5 for revision carpal tunnel, and 1 for revision radial tunnel syndrome. Average duration of symptoms prior to revision surgery with VersaWrap was 2 years (range 9 months to 6 years). Postoperatively, the mean DASH score was 57.7 and VAS 3.1. Mean s2PD median distribution was 7.3, s2PD ulnar distribution 8.9, m2PD median distribution 6.9 and m2PD ulnar distribution 7.3. All patients had subjective improvement of symptoms and were satisfied with their result. No patients in our cohort required further revisional surgery. In conclusion, the use of VersaWrap as a nerve protector following revision surgery for recurrent compressive neuropathies in the upper extremity was safe and effective.

Level of Evidence: IV; retrospective case series
Case report: Hemangioblastoma in the brainstem of a dog
Authors: Landsgaard Kirsten , St. Jean Samantha , Lovell Stephanie , Levine Jonathan , Gremillion Christine , Summers Brian , Rech Raquel R.
Published: March 2023

A 3-year-old castrated male, American Pit Bull Terrier presented to Texas A&M University due to a 3-week mixed cerebellar and general proprioceptive ataxia, circling, head tilt, and dull mentation. Neurologic examination revealed signs of vestibular and mesencephalic dysfunction. Postmortem examination revealed a 1.1 × 1 × 0.8-cm, soft, dark red, well-circumscribed, left-sided mass, extending from the crus cerebri of the midbrain caudally to the pons. Microscopically, the neoplasm was composed of a spindle-shaped interstitial population of cells interspersed between a prominent capillary network, consistent with the reticular pattern of hemangioblastoma. Interstitial cells had strong, diffuse, intracytoplasmic immunolabeling for neuron-specific enolase (NSE) and were variably positive for intracytoplasmic glial fibrillary acidic protein (GFAP). Vascular endothelial cells had strong diffuse, intracytoplasmic immunolabeling for von Willebrand factor (VWF) glycoprotein. To date, only six cases of hemangioblastoma have been reported in canines, five in the spinal cord, and one in the rostral cerebrum. Our case may represent the first canine hemangioblastoma localized to the brainstem.
Use of tranexamic acid in dogs with primary immune thrombocytopenia: A feasibility study
Authors: Olivares Gerard , Sharman Mellora , Miller Rachel , Kisielewicz Caroline , Seth Mayank
Published: March 2023

Objective

The aim of this feasibility study is to evaluate the use of tranexamic acid and its safe use alongside standard therapy in dogs with primary immune thrombocytopenia (ITP).

Design

This is a cohort feasibility study involving 10 dogs diagnosed with primary ITP that received standard therapy for ITP including corticosteroids, a single dose of vincristine, and omeprazole. Dogs were randomly divided into either the control group (n = 6) or the group receiving tranexamic acid (TXA group, n = 4).

Key findings

The mean time from the start of treatment until remission was 5 days in the TXA group and 6 days in the control group (P = 0.69). Two dogs, one in each group, did not achieve remission. Clinical bleeding scores were not significantly different between both groups (p = 0.43), and the median blood volume administered was 37.5 ml/kg for the TXA group and 9.72 ml/kg for the control group (p = 0.084). Three out of the four dogs receiving TXA of 20 mg/kg IV started vomiting within 15 min of administration and were given a reduced dose of 15 or 10 mg/kg IV.

Conclusion

Tranexamic acid did not confer a clinical benefit in this small cohort study and was associated with a high incidence of vomiting. This study provides useful information for the design of future trials in dogs with ITP receiving tranexamic acid including outcome measures and safety.
Incisions in Hepatobiliopancreatic Surgery: Surgical Anatomy and its Influence to Open and Close the Abdomen
Authors: Medina Pedrique Manuel , Robin Valle de Lersundi Álvaro , Avilés Oliveros Adriana , Ruiz Sara Morejón , López-Monclús Javier , Munoz-Rodriguez Joaquín , Blázquez Hernando Luis Alberto , Martinez Caballero Javier , García-Urena Miguel Ángel
Published: March 2023

Incisions performed for hepato-pancreatic-biliary (HPB) surgery are diverse, and can be a challenge both to perform correctly as well as to be properly closed. The anatomy of the region overlaps muscular layers and has a rich vascular and nervous supply. These structures are fundamental for the correct functionality of the abdominal wall. When performing certain types of incisions, damage to the muscular or neurovascular component of the abdominal wall, as well as an inadequate closure technique may influence in the development of long-term complications as incisional hernias (IH) or bulging. Considering that both may impair quality of life and that are complex to repair, prevention becomes essential during these procedures. With the currently available evidence, there is no clear recommendation on which is the better incision or what is the best method of closure. Despite the lack of sufficient data, the following review aims to correlate the anatomical knowledge learned from posterior component separation with the incisions performed in hepato-pancreatic-biliary (HPB) surgery and their consequences on incisional hernia formation. Overall, there is data that suggests some key points to perform these incisions: avoid vertical components and very lateral extensions, subcostal should be incised at least 2 cm from costal margin, multilayered suturing using small bites technique and consider the use of a prophylactic mesh in high-risk patients. Nevertheless, the lack of evidence prevents from the possibility of making any strong recommendations.
Retrieval of the Stratospheric Density by the Star Occultation
Authors: Wang Kedong , Li Zhennan , Zhang Shaoxiong
Published: March 2023

The navigation by the stellar refraction is important for a LEO (Low-Earth-Orbit) satellite, especially in a GNSS (Global Navigation Satellite System)-denied environment, since it is totally autonomous. However, the biggest barrier to the accurate navigation by the stellar refraction lies in the accurate stratospheric density. Therefore, the retrieval of the stratospheric density by the star occultation is proposed in this paper to acquire the stratospheric density globally with the high accuracy. Compared with the retrieval of the stratospheric density by the GPS (Global Positioning System) radio occultation, the retrieval by the star occultation can achieve a high vertical resolution. The retrieval of the stratospheric density by the star occultation is first derived in principle. Then, the performance of the retrieval, including the spatial resolution, the atmospheric attenuation, and the accuracy, was investigated in detail. The performance of the retrieval was also comprehensively verified by simulations. The simulation results prove that the retrieval of the stratospheric density by the star occultation can achieve a similar accuracy to that by the GPS radio occultation, but it has a higher vertical resolution than that by the GPS radio occultation, which is good for improving the accuracy of the navigation by the stellar refraction.
UAV Platforms for Data Acquisition and Intervention Practices in Forestry: Towards More Intelligent Applications
Authors: Sun Huihui , Yan Hao , Hassanalian Mostafa , Zhang Junguo , Abdelkefi Abdessattar
Published: March 2023

Unmanned air vehicle (UAV) systems for performing forestry applications have expanded in recent decades and have great economic benefits. They are validated to be more appealing than traditional platforms in various aspects, such as repeat rate, spatial resolution, and accuracy. This paper consolidates the state-of-the-art unmanned systems in the forestry field with a major focus on UAV systems and heterogeneous platforms, which are applied in a variety of forestry applications, such as wood production, tree quantification, disease control, wildfire management, wildlife conservation, species classification, etc. This review also studies practical applications under multiple forestry environments, including wild and managed forests, grassland, urban green parks, and stockyards. Special forest environments and terrains present customized demands for unmanned systems. The challenges of unmanned systems deployment are analyzed from environmental characterization, maneuverability and mobility improvement, and global regulatory interpretation. To better apply UAV systems into forestry, future directions are analyzed in terms of mobility enhancement and customized sensory adaption, which need to be further developed for synchronizing all possible agents into automatic functioning systems for forestry exploration.
Design and Development of Medium Energy Proton Detector Onboard FY-3E Satellite
Authors: Zhang Huanxin , Zhang Xiaoxin , Wang Jinhua , Huang Cong , Li Jiawei , Zong Weiguo , Shen Guohong , Zhang Shenyi , Yang Yong , Zhang Pengfei
Published: March 2023

This article introduces the instrument design of the medium energy proton detector (energy range: 30 keV–5 MeV) mounted on the FY-3E satellite. Through the design and optimization of the sensor signal processing circuit, the anti-electromagnetic interference ability of the medium energy particle detector is greatly enhanced. The designed aluminum plating on sensors can effectively exclude the light pollution to the medium energy protons. The designed permanent annular magnet has a deflection efficiency of more than 95% for medium energy electrons below 1.0 MeV. Additionally, by designing the logical working mode of the sensor, the contamination by other high energy particles (high energy electrons > 1.5 MeV, high energy protons > 5 MeV, and heavy ions) is excluded. Combining the above methods, the detector achieves the detection lower limit of 30 keV for medium energy protons. Its energy resolution is better than 15%@100 keV and the mixing ratio of electrons is less than 2%.
RETRACTED: Individual and Interactive Ecophysiological Effect of Temperature, Watering Regime and Abscisic Acid on the Growth and Development of Tomato Seedlings
Authors: Al-Deeb Taghleb , Abo Gamar Mohammad , Khaleel Sabah , Al-Ghzawi Abdul , Al Khateeb Wesam , Jawarneh Mohammad , Jahmani Mohammad , Al-Zoubi Omar , Habeeb Talaat
Published: March 2023

Climate change is a major concern to people all over the world. Most studies have considered singular or dual effects of climate change implications on plant growth and development; however, the combination of multiple factors has received little attention. We therefore studied the single and combined effects of two environmental stress factors (high temperature and water stresses) and abscisic acid on tomato seedlings (Solanum lycoperscum L.). Plants were grown in controlled environment growth chambers under two temperatures (22/18 °C or 28/24 °C; 16 h light/8 h dark), two watering regimes (well-watered or water-stressed), and two abscisic acid treatments (0 and 100 µL of 1mM abscisic acid solution, every other day). Plants were placed under experimental conditions for a total of 33 days, including a 13-day period of initial growth and hardening. Morphological, biochemical, and physiological parameters were measured to assess the growth and development of plants in response to the three factors. ANOVA and Scheffé’s multiple-comparison procedures were used to establish significant differences among treatments and among the three factors being manipulated. All three factors decreased plant height and growth rate. Dry mass accumulation was negatively affected by high temperatures. Transpiration, stomatal conductance, and gas exchange parameters were negatively affected by all three factors; additionally, net carbon dioxide assimilation was reduced by water stress and abscisic acid application. Non-photochemical quenching was decreased in plants grown under higher temperature and in abscisic acid-treated plants. Though it was not significant, abscisic acid appears to mitigate the negative effect of higher temperature and water stress on the nitrogen balance index and total chlorophyll content.
Industrial Hemp (Cannabis sativa L.) Agronomy and Utilization: A Review
Authors: Visković Jelena , Zheljazkov Valtcho D. , Sikora Vladimir , Noller Jay , Latković Dragana , Ocamb Cynthia M. , Koren Anamarija
Published: March 2023

Currently, there are increased interests in growing grain and fiber hemp (Cannabis sativa L.) as well as in large-scale hemp products. Cannabis has been grown/utilized for thousands of years as a fiber, grain, and drug/medicinal plant. However, the strict control of cannabis cultivation to combat illegal use, the spread of new yarns and oilseeds, and the advent of cheap synthetic fibers caused a decreased/eliminated hemp production. Hemp has been banned in most of the world for more than seven decades; it missed out on the Green Revolution and the adoption of new technologies and varieties, creating a knowledge gap. After the 2014 and 2018 Farm Bill in the USA, hemp became legal and the land grand universities launched research programs. The ability to utilize the entire plant for multiple purposes creates opportunity for the market to value hemp products. Hemp production technology varies depending on the type of hemp cultivated (grain, fiber, or cannabinoids), soil characteristics, and environmental factors. Hemp has the potential to be a very sustainable and ecologically benign crop. Hemp roots have a significant potential for absorbing and storing heavy metals such as lead, nickel, cadmium, and other harmful substances. In addition, hemp has been proven to be an excellent carbon trap and biofuel crop. Hemp has the ability to successfully suppress weeds, and it is generally regarded a pesticide-free crop. The purpose of this paper is to examine historic and recent industrial hemp (grain and fiber) literature, with a focus on hemp agronomy and utilization.
Reporting Antimicrobial-Related Adverse Drug Events in Jordan: An Analysis from the VigiBase Database
Authors: Mhaidat Nizar Mahmoud , Al-Azzam Sayer , Banat Hayaa Abdallah , Jaber Jaber Mohammad , Araydah Mohammad , Alshogran Osama Y. , Aldeyab Mamoon A.
Published: March 2023

This study aims to assess the reporting of antimicrobial-related adverse drug events (ADEs) in Jordan between 2003 and 2022. Data regarding the antimicrobial-related ADEs were extracted from the WHO’s global database (VigiBase) by the Rational Drug Use and Pharmacovigilance Department at the Jordan Food and Drug Administration (JFDA). A total of 279 Individual Case Safety Reports (ICSRs) were recorded. The number of ICSRs increased from 2019 onwards (219 out of 279 cases). This increase in the reported ADEs was influenced by the actions of the JFDA, including the introduction of electronic reporting forms, updating the national pharmacovigilance guidelines, which encouraged adverse drug reactions reporting, the implementation of the AMR-national action plan, the encouragement to report due to COVID-19 vaccine, and the continuous awareness campaigns and training programs. Skin and subcutaneous tissue disorders (n = 105; 19.48%) were the most reported antimicrobial-related ADEs. The highest number of ADEs was reported for tetracyclines (n = 101; 18.74%) followed by fluoroquinolones (n = 54; 10.02%), third-generation cephalosporines (n = 48; 8.9%), and carbapenems (n = 42; 7.79%). From the top 10 consumed antibiotics, the number of ADEs in patients who consumed Watch group antibiotics (97 ADEs) was higher than those who consumed Access group antibiotics (28 ADEs). The findings highlight the need to monitor and rationalize the use of Watch antibiotics. Enhanced reporting of antimicrobial-related adverse drug reactions is needed to inform antimicrobial stewardship and improve the pharmacovigilance system in Jordan.
Bioinformatics Analysis, Expression Profiling, and Functional Characterization of Heat Shock Proteins in Wolfi-poria cocos
Authors: Hu Xin , Tang Xue , Zhou Yumei , ahmad Bilal , Zhang Deli , Zeng Yue , Wei Jingyi , Deng Liling , Chen Shijiang , Pan Yu
Published: March 2023

Heat shock proteins (HSPs) play critical roles in regulating different mechanisms under high-temperature conditions. HSPs have been identified and well-studied in different plants. However, there is a lack of information about their genomic organization and roles in medicinal plants and fungi, especially in Wolfi-poria cocos (W. cocos). We identified sixteen heat shock proteins (HSPs) in W. cocos and analyzed in terms of phylogenetic analysis, gene structure, motif distribution patterns, physiochemical properties, and expression comparison in different strains. Based on phylogenetic analysis, HSPs were divided into five subgroups (WcHSP100, WcHSP90, WcHSP70, WcHSP60, and WcsHSP). Subgroups WcHSP100s, WcHSP90s, WcHSP70s, WcHSP60, and WcsHSPs were further divided into 3, 2, 3, 1, and 6 subfamilies, respectively. Moreover, the expression profiling of all HSP genes in five strains of W. cocos under different temperature extremes revealed that expression of most HSPs were induced by high temperature. However, every subfamily showed different expression suggesting distinctive role in heat stress tolerance. WcHSP70-4, WcHSP90-1, and WcHSP100-1 showed the highest response to high temperature stress. Heterologous expression of WcHSP70-4, WcHSP90-1, and WcHSP100-1 genes in Escherichia coli enhanced survival rate of E. coli during heat stress. These findings suggest the role of W. cocos heat shock genes in the high temperature stress tolerance.
Mechanical Properties and Functions of Elastin: An Overview
Authors: Trębacz Hanna , Barzycka Angelika
Published: March 2023

Human tissues must be elastic, much like other materials that work under continuous loads without losing functionality. The elasticity of tissues is provided by elastin, a unique protein of the extracellular matrix (ECM) of mammals. Its function is to endow soft tissues with low stiffness, high and fully reversible extensibility, and efficient elastic–energy storage. Depending on the mechanical functions, the amount and distribution of elastin-rich elastic fibers vary between and within tissues and organs. The article presents a concise overview of the mechanical properties of elastin and its role in the elasticity of soft tissues. Both the occurrence of elastin and the relationship between its spatial arrangement and mechanical functions in a given tissue or organ are overviewed. As elastin in tissues occurs only in the form of elastic fibers, the current state of knowledge about their mechanical characteristics, as well as certain aspects of degradation of these fibers and their mechanical performance, is presented. The overview also outlines the latest understanding of the molecular basis of unique physical characteristics of elastin and, in particular, the origin of the driving force of elastic recoil after stretching.
Anaemia and Congestion in Heart Failure: Correlations and Prognostic Role
Authors: Scicchitano Pietro , Iacoviello Massimo , Massari Antonio , De Palo Micaela , Potenza Angela , Landriscina Raffaella , Abruzzese Silvia , Tangorra Maria , Guida Piero , Ciccone Marco Matteo , Caldarola Pasquale , Massari Francesco
Published: March 2023

The aim of this study was to evaluate the relationship between anaemia and biomarkers of central/peripheral congestion in heart failure (HF) and the impact on mortality. We retrospectively evaluated 434 acute/chronic HF (AHF/CHF) patients. Anaemia was defined as haemoglobin levels <12 g/dL (women) or <13 g/dL (men). The brain natriuretic peptide (BNP) and hydration index (HI) were measured. The endpoint of the study was all-cause mortality. Anaemia occurred in 59% of patients with AHF and in 35% with CHF (p < 0.001) and showed a significant correlation with the NYHA functional class and renal function. BNP and HI were significantly higher in patients with anaemia than in those without anaemia. Independent predictors of anaemia included BNP, estimated creatinine clearance (eCrCL), and HI. The all-cause mortality rate was 21%, which was significantly higher in patients with anaemia than in those without anaemia (30% vs. 14%, p < 0.001; hazard ratio: 2.6). At multivariate Cox regression analysis, BNP, eCrCL, and HI were independent predictors for mortality (Hazard ratios: 1.0002, 0.97, and 1.05, respectively), while anaemia was not. Anaemia correlates with HF status, functional class, renal function, BNP, and HI. Anaemia was not an independent predictor for mortality, acting as a disease severity marker in congestive patients rather than as a predictor of death.
Subclinical Carotid Atherosclerosis in Patients with Rheumatoid Arthritis at Low Cardiovascular Risk
Authors: Gerasimova Elena V. , Popkova Tatiana V. , Gerasimova Daria A. , Markina Yuliya V. , Kirichenko Tatiana V.
Published: March 2023

Objective: To evaluate the rate of subclinical carotid atherosclerosis and clinical significance of immunoinflammatory markers in patients with rheumatoid arthritis (RA) at low cardiovascular risk. Materials and Methods: The study included 275 RA patients and a control group of 100 participants without autoimmune diseases. All study participants were at low cardiovascular risk, calculated by the QRISK3 scale (<20%), and free of cardiovascular disease. Ultrasound examination of carotid arteries was performed to measure cIMT and to detect atherosclerotic plaques (ASP) in carotid arteries. sIСАМ-1, sVСАМ, and sCD40L levels were determined by enzyme immunoassay. Results: Carotid ASP was observed more frequently in RA patients (27%) than in the control group (17%), p = 0.03. The frequency of ASP in RA patients did not depend on the disease’s stage or activity. There was a significant correlation between cIMT and age, cardiovascular risk determined by QRISK3, level of total cholesterol, LDL, and blood pressure in RA patients, p < 0.05 in all cases. No correlation between cIMT and blood levels of sCD40L, sVCAM, and sICAM was found. In RA patients, a higher concentration of sVCAM was detected in the carotid ASP group compared to the non-atherosclerotic group. sCD40L was associated with cIMT and total cholesterol in the ASP group and with total cholesterol and blood pressure in non-atherosclerotic patients. Conclusions: Subclinical atherosclerotic lesions of the carotid arteries were observed significantly more frequently in RA patients with low cardiovascular risk than in the control group. The results of the study demonstrate the association between cIMT, traditional cardiovascular risk factors, and immunoinflammatory markers in RA patients.
Endometriosis: Update of Pathophysiology, (Epi) Genetic and Environmental Involvement
Authors: Monnin Nicolas , Fattet Anne Julie , Koscinski Isabelle
Published: March 2023

Endometriosis is a chronic disease caused by ectopic endometrial tissue. Endometriotic implants induce inflammation, leading to chronic pain and impaired fertility. Characterized by their dependence on estradiol (via estrogen receptor β (ESRβ)) and their resistance to progesterone, endometriotic implants produce their own source of estradiol through active aromatase. Steroidogenic factor-1 (SF1) is a key transcription factor that promotes aromatase synthesis. The expression of SF1 and ESRβ is enhanced by the demethylation of their promoter in progenitor cells of the female reproductive system. High local concentrations of estrogen are involved in the chronic inflammatory environment favoring the implantation and development of endometriotic implants. Similar local conditions can promote, directly and indirectly, the appearance and development of genital cancer. Recently, certain components of the microbiota have been identified as potentially promoting a high level of estrogen in the blood. Many environmental factors are also suspected of increasing the estrogen concentration, especially prenatal exposure to estrogen-like endocrine disruptors such as DES and bisphenol A. Phthalates are also suspected of promoting endometriosis but throughmeans other than binding to estradiol receptors. The impact of dioxin or tobacco seems to be more controversial.
Advances of Mussel-Inspired Nanocomposite Hydrogels in Biomedical Applications
Authors: Ma Haohua , Qiao Xin , Han Lu
Published: March 2023

Hydrogels, with 3D hydrophilic polymer networks and excellent biocompatibilities, have emerged as promising biomaterial candidates to mimic the structure and properties of biological tissues. The incorporation of nanomaterials into a hydrogel matrix can tailor the functions of the nanocomposite hydrogels to meet the requirements for different biomedical applications. However, most nanomaterials show poor dispersion in water, which limits their integration into the hydrophilic hydrogel network. Mussel-inspired chemistry provides a mild and biocompatible approach in material surface engineering due to the high reactivity and universal adhesive property of catechol groups. In order to attract more attention to mussel-inspired nanocomposite hydrogels, and to promote the research work on mussel-inspired nanocomposite hydrogels, we have reviewed the recent advances in the preparation of mussel-inspired nanocomposite hydrogels using a variety of nanomaterials with different forms (nanoparticles, nanorods, nanofibers, nanosheets). We give an overview of each nanomaterial modified or hybridized by catechol or polyphenol groups based on mussel-inspired chemistry, and the performances of the nanocomposite hydrogel after the nanomaterial’s incorporation. We also highlight the use of each nanocomposite hydrogel for various biomedical applications, including drug delivery, bioelectronics, wearable/implantable biosensors, tumor therapy, and tissue repair. Finally, the challenges and future research direction in designing mussel-inspired nanocomposite hydrogels are discussed.
EEG Alpha Band Responses Reveal Amplification Benefits in Infants with Hearing Loss
Authors: Uhler Kristin , Tollin Daniel J. , Gilley Phillip M.
Published: March 2023

Our objective was to examine the effects of hearing aid amplification on auditory detection and discrimination in infants who were hard of hearing (IHH) using a physiological measure of auditory perception. We recorded EEG from 41 sleeping IHH aged 1.04 to 5.62 months while presenting auditory stimuli in a mismatch response paradigm. Responses were recorded during two listening conditions for each participant: aided and unaided. Temporal envelopes of the mismatch response in the EEG alpha band (6–12 Hz) were extracted from the latent, time-frequency transformed data. Aided alpha band responses were greater than unaided responses for the deviant trials but were not different for the standard trials. Responses to the deviant trials were greater than responses to the standard trials for the aided conditions but were not different for the unaided conditions. These results suggest that the alpha band mismatch can be used to examine both detection and discrimination of speech and non-speech sounds in IHH. With further study, the alpha band mismatch could expand and refine our abilities to validate hearing aid fittings at younger ages than current clinical protocols allow.
Analysis of Self-Perceived Physical Fitness of Physical Education Students in Public Schools in Extremadura (Spain)
Authors: Galán-Arroyo Carmen , Mendoza-Muñoz David Manuel , Pérez-Gómez Jorge , Hernández-Mosqueira Claudio , Rojo-Ramos Jorge
Published: March 2023

Adolescence is a stage of crucial physiological and psychological changes within the individual’s life cycle, where fitness work is important. With self-perception being crucial in relation to adolescent health and well-being, a positive perception of fitness is directly related to increased practice or higher level of physical activity (PA). Thus, the aims were: (1) to analyze, with the Visual Analogue Fitness Perception Scale for Adolescents (FP VAS A), the self-perceived physical fitness (PF) of high school students, (2) to investigate if there are differences according to sex and school location, and (3) to study the correlations between the items of the FP VAS A with age and body mass index (BMI). For this purpose, a cross-sectional study was designed with a total of 961 participants, 48.8% boys and 51.2% girls in secondary education, where 31.9% studied in rural schools and 68.1% in urban schools. The FP VAS A scale was used to assess self-reported PF. Regarding the results, there were statistically significant differences between sexes (p < 0.001), with boys showing higher scores than girls in all the items of the FP VAS A scale, with the exception of global flexibility. Inverse, mean and significant correlations were established between BMI and self-perceived overall PF (r = −0.202; p < 0.001), cardiorespiratory endurance (r = −0.226; p < 0.001) and movement speed (r = −0.268; p < 0.001). Between age and self-perceived cardiorespiratory endurance (r = −0.138; p < 0.001) an inverse, mean and significant correlation was also observed. In conclusion, boys showed a better self-perception of PF than girls for all physical abilities, with the exception of flexibility. School location was not shown to influence students’ self-perceived PF. In addition, most of the self-perceived PF abilities for overall fitness correlated inversely with BMI.
Passive Control of Boundary Layer on Wing: Numerical and Experimental Study of Two Configurations of Wing Surface Modification in Cruise and Landing Speed
Authors: Karkoulias Dionysios G. , Bourdousi Panagiota-Vasiliki N. , Margaris Dionissios P.
Published: March 2023

Minimizing the carbon footprint of the aviation industry is of critical importance for the forthcoming years, allowing the mitigation of climate change through fossil fuel economy. Significant progress toward this goal can be achieved through the aerodynamic optimization of wing surfaces. In a previous study, a custom-designed wing equipped with an Eppler 420 airfoil, including an appendant custom-designed blended winglet, was developed and studied in flight conditions. The present paper researches potential improvements to the aerodynamic behavior of this wing by attempting to regenerate the boundary layer. The main goal was to achieve passive control of the boundary layer, which would be approached by means of two different configurations. In the first case, dimples were added at the points where the separation of the boundary layer was expected, for the majority of the wing surface; in the second case, bumps of the same diameter were added at the same points. Both wings were studied in two different Reynolds (Re) numbers and five angles of attack (AoA). The computational fluid dynamics (CFD) simulations were implemented using a pressure-based solver, the spatial discretization was conducted with a second-order upwind scheme, and the k-omega SST (k-ω SST) turbulence model was applied by utilizing the pseudo-transient method. The experimental procedure was conducted in an open-type subsonic flow wind tunnel, for Reynolds 86,000, with 3D-printed models of the wings having undergone suitable surface treatment. The numerical and experimental results converged, showing a degradation in the wing’s aerodynamic performance when bumps were implemented, as well as a slight improvement for the configuration with dimples.
Evolution Regularity of Continuous Surface Structures Shaped by Laser-Supported Fictive-Temperature Modifying
Authors: Liao Wei , Zhang Chuanchao , Chen Jing , Yang Ke , Zhang Lijuan , Jiang Xiaolong , Bai Yang , Wang Haijun , Luan Xiaoyu , Jiang Xiaodong , Yuan Xiaodong , Zheng Wanguo , Zhu Qihua
Published: March 2023

The influence of residual heat on the fictive temperature modification zone of fused silica for different CO2 laser scanning time intervals was investigated to precisely control the profiles of hydrofluoric (HF) acid-etched fused silica surface, which were formed by the increasing HF acid-etching rate for fused silica with increasing fictive temperature induced by CO2 laser scanning. The surface profiles of HF acid-etched fused silica treated by different scanning time intervals of CO2 laser were measured by a stylus profilometry, and experimental results indicate that the CO2 laser scanning time intervals intensively influence the HF acid-etched surface profiles of fused silica. The increasing depth of surface profiles treated by shorter scanning time intervals shows that the fictive temperature modification zone significantly expands. Numerical simulations of the fictive temperature modification zone induced by different scanning time intervals indicate that the residual heat of CO2 laser scanning with shorter time intervals leads to a dramatical increase in the fictive temperature modification zone. By adjusting the residual heat of CO2 laser scanning intervals, various surface profiles of fused silica can be obtained by HF acid-etching of fused silica.
EU: The Effect of Energy Factors on Economic Growth
Authors: Aliev Ayaz , Magomadova Madina , Budkina Anna , Harputlu Mustafa , Yusifova Alagez
Published: March 2023

In this article, we investigate the effect of different energy variables on economic growth of several oil-importing EU member states. Three periods from 2000 to 2020 were investigated. Three different types of regression models were constructed via the gretl software. Namely, the OLS, FE, and SE approaches to panel data analysis were investigated. The FE approach was chosen as the final one. The results suggest the importance of the consumption of both oil and renewable energy on economic growth. Crises of certain periods also had a noteworthy effect as well.
Analysis of Hierarchical Grid Refinement Techniques for the Lattice Boltzmann Method by Numerical Experiments
Authors: Schukmann Alexander , Schneider Andreas , Haas Viktor , Böhle Martin
Published: March 2023

Over the last few decades, several grid coupling techniques for hierarchically refined Cartesian grids have been developed to provide the possibility of varying mesh resolution in lattice Boltzmann methods. The proposed schemes can be roughly categorized based on the individual grid transition interface layout they are adapted to, namely cell-vertex or cell-centered approaches, as well as a combination of both. It stands to reason that the specific properties of each of these grid-coupling algorithms influence the stability and accuracy of the numerical scheme. Consequently, this naturally leads to a curiosity regarding the extent to which this is the case. The present study compares three established grid-coupling techniques regarding their stability ranges by conducting a series of numerical experiments for a square duct flow, including various collision models. Furthermore the hybrid-recursive regularized collision model, originally introduced for cell-vertex algorithms with co-located coarse and fine grid nodes, has been adapted to cell-centered and combined methods.
Valorization of an Old Variety of Triticum aestivum: A Study of Its Suitability for Breadmaking Focusing on Sensory and Nutritional Quality
Authors: Bianchi Alessandro , Venturi Francesca , Zinnai Angela , Taglieri Isabella , Najar Basma , Macaluso Monica , Merlani Giorgio , Angelini Luciana Gabriella , Tavarini Silvia , Clemente Clarissa , Sanmartin Chiara
Published: March 2023

“Avanzi 3-Grano 23” (G23) is an old variety of Triticum aestivum from the mountain areas of Lunigiana (north Tuscany, Italy), where traditional farming communities have contributed to its success and on-farm conservation. G23 flour, traditionally used for typical food products, is characterized by particular nutritional and sensory traits but has technological properties which limit its suitability for breadmaking. The aim of this work was to evaluate how to promote the use of G23 through the optimization of bread formulation by leveraging both flour blending and the leavening system. During the preliminary test, three different mixes of G23 flour and a strong flour (C) were tested in terms of their leavening power as a function of leavening agent (baker’s yeast or sourdough). The selected M2 flour, composed of G23:C (1:1 w/w), was used for further breadmaking trials and 100% C flour was utilized as a control. The sourdough bread obtained with the M2 flour (SB-M2) showed an improved sensory profile compared with the related control (SB-C). Furthermore, SB-M2 exhibited the best aromatic (high content in aldehydes, pyrazines and carboxylic acids) and phytochemical profile (total polyphenols and flavonoids content and antioxidant activity). In contrast, the use of baker’s yeast, although optimal from the point of view of breadmaking, did not result in the same levels of aromatic complexity because it tends to standardize the product without valorizing the sensory and nutritional qualities of the flour. In conclusion, in the experimental conditions adopted, this old wheat variety appears to be suitable for the production of sourdough bakery products.
The Past and Future of East Asia to Italy: Nearly Global VLBI
Authors: Giovannini Gabriele , Cui Yuzhu , Hada Kazuhiro , Yi Kunwoo , Ro Hyunwook , Sohn Bong Won , Takamura Mieko , Buttaccio Salvatore , D’Ammando Filippo , Giroletti Marcello , Hagiwara Yoshiaki , Kino Motoki , Kravchenko Evgeniya , Maccaferri Giuseppe , Melnikov Alexey , Niinuma Kotaro , Orienti Monica , Wajima Kiyoaki , Akiyama Kazunori , Doi Akihiro , Byun Do-Young , Hirota Tomoya , Honma Mareki , Jung Taehyun , Kobayashi Hideyuki , Koyama Shoko , Melis Andrea , Migoni Carlo , Murata Yasuhiro , Nagai Hiroshi , Sawada-Satoh Satoko , Stagni Matteo
Published: March 2023

We present here the East Asia to Italy Nearly Global VLBI (EATING VLBI) project. How this project started and the evolution of the international collaboration between Korean, Japanese, and Italian researchers to study compact sources with VLBI observations is reported. Problems related to the synchronization of the very different arrays and technical details of the telescopes involved are presented and discussed. The relatively high observation frequency (22 and 43 GHz) and the long baselines between Italy and East Asia produced high-resolution images. We present example images to demonstrate the typical performance of the EATING VLBI array. The results attracted international researchers and the collaboration is growing, now including Chinese and Russian stations. New in progress projects are discussed and future possibilities with a larger number of telescopes and a better frequency coverage are briefly discussed herein.