bluuebunny/crossref_metadata_2025 huggingface dataset:
Precedence in Ironic Fiction Discourse: A Functional and Pragmatic Aspect
Authors: Kuznetsova Anna Vladimirovna
Published: December 2022

The aim of the research is to determine the functional and pragmatic features of precedence implementation in ironic fiction discourse. The paper examines multilevel correlations of precedence and irony, which make it possible to identify markers of ironic context and ironic implicatures in fiction discourse contributing to the implementation of the author’s intentions in fiction communication and allowing the addressee to interpret correctly the ironic communication of characters and the author’s ironic assessment. Scientific novelty of the research lies in substantiating the mutual influence of irony and precedence in the production of fiction discourse manifesting not only individually significant and nationally conditioned meanings but also universal meanings. The research findings prove that precedent phenomena can act as markers of ironic context in fiction discourse. The ironic meaning is always implicit, but it must be interpreted by the addressee in accordance with the author’s intention. Precedence and irony in E. L. Schwartz’s play “The Dragon” form a complex synthesis that determines the “completion” of meanings of the discursive space in the process of receptive and interpretative activity of the addressee and the implementation of fiction communication as a dialogue between the author and the reader (viewer): irony cannot be decoded by the addressee without the correct “recognition” of precedent phenomena that act as its markers.
Toponyms Use in Evaluative -Characterizing Function in the English-Language and Russian-Language Fictional Discourse
Authors: Kondrashova Vera Niсkolaevna , Shustrova Elena Nickolaevna
Published: December 2022

The aim of the study is to identify the features of using toponyms in the implementation of the eva¬luative-characterizing function in the English-language and Russian-language fictional discourse. The scientific novelty of the work lies in conducting a comparative analysis of the toponyms functioning in fictional discourse on the basis of the Russian and English languages. Here for the first time, the general pragmatic goals of using toponyms in fictional discourse in the implementation of the evaluative-characterizing function have been identified: to convey a character’s psychological state, to express evocatively the attitude towards the subject or object of evaluation, to express an opinion in a playful or ironic form. As a result of the study, it has been found that in both the discourses, toponyms are most often used to express the socio-cultural aspect of evaluation, as well as to describe a character psychologically and characterize the physical para¬meters of the described subjects and objects. Some differences that represent the culturological opposition “own - alien” have been revealed when analysing the use of toponyms of a native country and a foreign one in the Russian-language and English-language discourse. In the Russian-language fictional discourse, such opposition has been observed not only in relation to other countries, but also within the country when comparing Moscow and the provinces.
Artistic Originality of L. Chebodaeva’s Works for Children
Authors: Cheltygmasheva Larisa Viktorovna
Published: December 2022

The article, for the first time in the Khakass literary criticism, considers L. I. Chebodaeva’s literary work, which has not previously become a subject of scientific study. The aim is to identify the features of the artistic originality of L. Chebodaeva’s works for children. The scientific novelty is due to the introduction into scientific circulation of works addressed to children as an important material for the scientific study of the modern literary process of Khakassia. The article proves that animalistic images in L. Chebodaeva’s fairy tales, composed as fairy tales - dialogues, are a means of moral teaching, condemnation of human vices. The paper substantiates the use of a literary device in the stories - the boy Ayolka’s dream, the image of the hero-narrator grandfather Amon and the functions of fairy-tale narration. As a result, it has been revealed that, performing disciplinary, educational and aesthetic functions, L. Chebodaeva’s works have such an artistic form that is accessible to children’s perception; they introduce children of primary and secondary school age to the spiritual and moral values and traditions of the Khakass people, nature and wildlife of their native land, beauty and expressiveness of the artistic word and are focused on the formation of a highly moral person who honors their people, land, native language, national traditions, etc.
A User Research on Alternative Media
Authors: Demir Deniz
Published: December 2022

This research aims to contribute to the debate on the concept of alternative media by trying to understand what this term means for its users. The responses that emerged in the focus group discussions revealed which values and which characteristics are important in the eyes of the participants to define a media as “alternative”. The interviews were analyzed with the grounded theory method and the themes and sub-themes were determined with the open coding method. The first point to note is that interviewees consider a wide range of media as alternative. These include a channel affiliated with a large conglomerate; news broadcasters of different countries; some small-scale media organizations, journalists broadcasting through social media platforms, opposition and pro-government publishers coexist. In the study, it was determined that the alternative media users of the focus groups attach more importance to the content than the formal features such as being non-commercial. Keywords: alternative media, mainstream media, user research, journalism, focus group
Evaluation of the heavy metal content of Sweetgum tree (Liquidambar orientalis Mill.) distributed in Mugla province
Authors: ALPTEKİN Fatma , YILDIZTEKİN Mahmut
Published: December 2022

This study, it was aimed to investigate the nutritional status and heavy metal contents of Liquidambar orientalis Mill., an endemic species naturally distributed in Marmaris, Koycegiz, and Fethiye districts of Mugla province. When the soil heavy metal contents are examined, it has been determined that the Cr and Ni values are quite high in the Koycegiz and Marmaris samples. Cd, Co, Cr, Ni and Pb contents in the leaves, respectively; it was determined to be in the range of 0.04-0.09 ppm, 0.4-1.80 ppm, 2.85-6.87 ppm, 9.28-40.49 ppm and 0.52-2.15 ppm. Although some heavy metals were found to be above the limit values, no physical evidence was found that the plants in the study were adversely affected by these high values metabolically.
Investigation of yield and yield components in main crop soybean genotypes in Adana conditions
Authors: YAŞAR Mustafa , SEZGİN Mehmet
Published: December 2022

The research was carried out in Adana conditions to determine the relati-onships between seed yield and yield components of some soybean ge-notypes depending on the years. In this research, which was carried out in 2015 and 2016 years, it was established with 5 soybean varieties and one variety candidate and according to Randomized Complete Block De-sign with 4 replications. In the combined analysis of variance, the year*genotype interaction was insignificant in terms of yield and yield components, while other sources of variation (year and genotype) were found to be statistically significant compared to P <0.01. Seed yield showed changed between 5782-6788 kg ha-1 in 2015 and 3597-4359 kg ha-1 in 2016. In the correlation between the examined traits; While there was a significant and positive relationship between seed yield and day to flowering, days to maturity, first pod height and oil rate, there was a significant and negative relationship between 1000 seed weight and the number of pods per plant. The varyans analysis showed that the inter-actions of year, genotype and year*genotype were significant in terms of seed yield and yield components of genotypes. As a result, Cinsoy, variety candidate 1 (Mona) and Blaze of varieties showed high performance in Adana conditions, and it was determined that the effect of the environment was higher than the effect of genotype and interaction in terms of seed yield and other traits. As a result of this study, the variety candidate 1 was registered under the name Mona. In addition, it was concluded that Cinsoy, Blaze and newly registered Mona varieties can be recommended for main crop soybean cultivation in Adana conditions.
COVID-19 Günlerinde İstanbul’da Yürümek: Üniversite Eğitimli Çalışanlar Örneği
Authors: ORHAN Gözde , KARLIDAĞ Sercan
Published: December 2022

Bu çalışma, COVID-19 salgını süresince sıklıkla başvurulan sokağa çıkma yasakları dönemlerinde araç kullanımının kısıtlanması nedeniyle yahut kent kullanıcılarının bulaş riskini azaltmak için kendi iradeleriyle toplu taşıma araçlarından kaçınmaları dolayısıyla kentle yeniden ilişkilenmelerini sağlayan yürüme pratiğini, İstanbul gibi yayaların ulaşım hakkının oldukça sınırlı olduğu bir ölçekten ele almayı amaçlamaktadır. Çalışma, yaya olmanın kentsel bir deneyim olarak tarihsel ve felsefi veçhelerini tartışmaya açtıktan sonra, hızlı ve kesintisiz bir hareketlilik (mobilite) üzerine kurulu neoliberal kentte yürümenin nasıl unutulduğuna ve COVID-19 salgını “sayesinde” nasıl yeniden hatırlandığına yoğunlaşmaktadır. Araştırmada amaçlı ve kartopu örnekleme yoluyla “üniversite eğitimli çalışanlara” ulaşılmıştır. Araştırmaya katılmaya gönüllü olmuş 46 katılımcı, İstanbul’un merkez ve periferisi denebilecek 23 farklı ilçesinde ikamet etmektedir. Çalışmada, toplu taşım kullanımındaki değişime dair sosyo-demografik bulguların ötesinde, niteliksel analiz bulgularına göre katılımcıların algı, değerlendirme ve deneyimlerinde çeşitli temalara ulaşılmıştır: Arzulanan bir edim olarak yürümek, olumlu duygulanım pahasıyla ulaşılan bir edim olarak yürümek, salgın günleriyle başa çıkma yolu ve kenti evcilleştirme pratiği olarak yürümek, sosyalleşme biçimi olarak yürümek, politik bir edim olarak yürümek temaları kent tarihi, kent sosyolojisi, sosyal psikoloji ve çevre psikolojisi literatürleri ekseninde tartışılmıştır. Araştırma, COVID-19 salgın günlerinde İstanbul’da yaşayan üniversite eğitimli çalışanlara odaklanmasıyla, giderek artan İstanbul Çalışmaları yazınına katkı sunmaktadır.
A live-attenuated COVID-19 vaccine as only solution to mitigate pericardial effusion and myocardial side effects
Authors: Tabaee Damavandi Pardis
Published: December 2022

A short perspective.
Acoustic full waveform inversion for 2-D ambient noise source imaging
Authors: Datta Arjun , Shekar Bharath , Kumar Pushp
Published: December 2022

We present a method for estimating seismic ambient noise sources by acoustic full waveform inversion of interstation cross-correlations. The method is valid at local scales for laterally heterogeneous media, and ambient noise sources confined to the Earth's surface. Synthetic tests performed using an actual field array geometry, are used to illustrate three unique aspects of our work. First: the method is able to recover noise sources of arbitrary spatial distribution, both within and outside the receiver array, with high fidelity. This holds true for complex velocity models and does not require a good initial guess for inversion, thereby addressing an outstanding issue in the existing research literature. Second: we analyse the extent of biases in source inversion that arise due to inaccurate velocity models. Our findings indicate that source inversion using simplified (e.g. homogeneous) velocity models may work reliably when lateral variations in velocity structure are limited to 5 or 10\% in magnitude, but is vitiated by strong variations of 20\% or higher, wherein the effect of strong scattering and/or phase distortions become significant. Finally, our technique is implemented without the adjoint method, which is usually inextricably linked to full waveform inversion. Inversions are performed using source kernels computed for each receiver pair, and this approach is computationally tractable for real-world problems with small aperture seismic arrays.
Acting Impulsively when “Upset”: Examining Associations among Negative Urgency, Undifferentiated Negative Affect, and Impulsivity using Momentary and Experimental Methods
Authors: Racine Sarah Elizabeth , Bicaker Ege , Trolio Vittoria , Lane Sean Patrick
Published: December 2022

A combined EMA and experimental study
Confirmatory factor analysis of the Brief Reading the Mind in the Eyes Test (RMET-10) in three large samples reveals strong evidence of unidimensionality
Authors: Yu Bridget , Levy Neil L , Crone Damien
Published: December 2022

The 36-item Reading the Mind in the Eyes Test (RMET) is an extensively administered behavioral measure of cognitive empathy (and emotion perception in particular). Numerous brief forms of the RMET have been developed in attempts to both improve its psychometric properties and reduce testing burden. Notably, little systematic validation work exists in the literature for one of the most promising brief forms proposed: the abbreviated 10-item RMET scale developed by Olderbak et al. (2015; which we refer to as the RMET-10). To this end, we present Confirmatory Factor Analyses (CFA) of the RMET-10 in three independent samples of American adults (total N = 3,121). CFAs in each sample consistently indicated that the RMET-10 exhibits excellent factorial validity and moderate levels of internal consistency despite its substantially reduced length. Overall, our results support the use of the RMET-10 as a brief but effective (if narrow) measure of cognitive empathy.
Social Motivations’ Limited Influence on Habitual Behavior: Tests from Social Media Engagement
Authors: Anderson Ian Axel , Wood Wendy
Published: December 2022

Motivations that drive initial or occasional actions may have less impact as people repeat a behavior and form habits that are automatically cued by contexts. We tested this shifting role of motivation with social media engagement. Specifically, we assessed how the posting rates of habitual and nonhabitual social media users varied with social rewards of others’ reactions and comments (preliminary study, Study 1) and with a platform design change in 2007 that increased the salience of one’s own and others’ posts (Study 2). In a preliminary study with Instagram users and Study 1’s controlled observation of Facebook posting, non-habitual users increased engagement after receiving social rewards on a prior post, whereas habitual ones were unaffected. In Study 2, occasional Facebook users were motivated by the platform design to engage more online but frequent users were not; instead, their posting was disrupted by the new platform features. Finally, suggesting that these effects were not due to waning motivation, habitual users self-reported being concerned about others’ reactions and predicted they would increase engagement following rewards and the platform change. Thus, frequent users responded automatically out of habit despite these motivations.
Approximation by Some Stancu Type Linear Positive Operators
Authors: Sharma Prerna
Published: December 2022

Present paper is the study about Stancu type generalization of modified Beta-Szasz operators and their q-analogues. We obtain some approximation properties for these operators and estimate the rate of convergence by using the first and second order modulus of continuity. Author also investigates the statistical approximation properties of the q-Beta-Stancu operators using Korokvin theorem.
Особливості художньої інтерпретації образу нащадка генія у романі Б. Коломійчука „Моцарт із Лемберга”
Authors: КОВПІК Світлана
Published: December 2022

The paper deals with the peculiarities of literary modeling the image of a genius in the novel „Mozart from Lamberg” by the modern Ukrainian writer B. Kolomiychuk. It is claimed that Franz’s motivation for genius was formed in childhood (his mother constantly reminded him of his father and tried to convince his son that he was the same genius composer as his father). He also had innate abilities of reality reflection and unique presentation of its essence (Franz heard music everywhere, different sounds inspired him to create new compositions). It is noted that in the novel the writer did not demonstrate the power of the inherited genotype, as well as the development of intelligence and favorable conditions for its strengthening. Franz was well aware that his father’s genius of composition would never be achieved. However, he still wanted to be worthy of his father’s memory. Such leading traits of Franz’s character as honesty and responsibility contributed to the fact that he established himself as a person who had his own unique abilities.
Citizenship Under Pressure: Mapping Debates Over Religious Freedom in the Second Decade in Quebec
Authors: Hmimssa Azeddine
Published: December 2022

In recent years and following a long process of secularization, social change, and immigration, Quebec is currently a diverse environment with rich dynamics around Quebecness, citizenship, identity politics, and reasonable accommodations. Following sensitive political events, Quebec saw many battles over secularism and religious pluralism. A series of debates were enmeshed with political debates about the true meaning of secularism and embroiled with fear of religion and immigrants. This ethnographic inquiry maps out the existing tendencies during different periods of repercussions and tensions around Quebec’s secularism. The article outlines key clustering patterns and ethico-religious hierarchies and their genesis while responding to the 2013 Charter of Values of Quebec, the debates on the 2014 attacks against Canadian soldiers by presumed ISIS members in Canada, and the 2019 secularism law, Bill 21, adopted by the Coalition Avenir Québec (CAQ) government in June 2019. The fieldwork was conducted between May 2013 and June 2020 and is based on 44 events and interviews with major key participants (Catholics, Muslims, Secularists) in Montreal. The main findings show that the dynamics behind the incongruities within social groups appear to be generating overlapping alliances; while discourses of many groups seem to be unified in appearance, they are divided into many layers, which serves the purpose of opposing or supporting the government’s policies and legislation. Partnerships created in such conditions remain ephemeral, restrained with an allegiance to the same political tendency, and controlled by cultural or ideological homogeneity. Furthermore, there is more hate and violence when perpetrators believe that they benefit from anonymity.
Integrating Communication Skills, Awareness of Self and Others, and Reflective Feedback into One Inclusive Anatomical Representation of Relationship-Centered Health Care
Authors: Englar Ryane E. , Graham Brett Teresa
Published: December 2022

The American Veterinary Medical Association Council on Education mandates in standard 11 that all accredited colleges of veterinary medicine must develop and deliver formal processes by which students are observed and assessed in nine competencies. The eighth competency combines clinical communication and sensitivity toward soliciting and understanding individual narratives across a diverse clientele to facilitate health care delivery. Several frameworks have been designed to structure health care consultations for teaching and coaching purposes. The Calgary–Cambridge guide (CCG) provides an evidence-based approach to outlining the flow of consultations, incorporating foundational communication skills and elements of relationship-centered care into a series of sequential tasks. Although the CCG was intended for use as a flexible tool kit, it lacks visible connections between concrete experiences (e.g., the consultation) and reflective observation (e.g., the feedback). This teaching tip describes the development of a novel anatomical representation of the consultation that integrates process elements of the CCG with other core curricular concepts. By combining knowledge, technical skills, critical thinking, reflection, cultural humility, and self-awareness into a skeletal consultation model, linkages are established between communication and intergroup dialogue skills and diversity and inclusion (D&I). This model has been further adapted as feline, caprine, porcine, equine, avian, and reptilian versions for in-class use as strategic visual aids that highlight key areas of focus for Professional Skills class sessions. Future developments by the authors will explore how to link species-specific consultation models to assessment rubrics to reinforce the connection between content ( what) and process ( how).
INFLUENCE OF ARTERIAL HYPERTENSION AND CHRONIC HEART FAILURE ON THE EFFECTIVENESS OF SINUS RHYTHM RESTORATION IN PATIENTS WITH ATRIAL FLUTTER
Authors:   Novosibirsk State Medical University, Novosibirsk, Russia, Tereshchenko A.V. , Nepomnyashchikh D.L. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Miller O.N. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Postnikova O.A. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Ovechkina Y.V. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Abramova E.E. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Vinogradova E.V. ,   Novosibirsk State Medical University, Novosibirsk, Russia
Published: December 2022

The use of overdrive transesophageal cardiac pacing (OTECP) in atrial flutter (AF) can reduce the number of external electrical cardioversion (EEC) in arrhythmia refractory to drug-induced cardioversion. The conversion of AF to atrial fibrillation (AFib) with subsequent spontaneous sinus rhythm (SR) restoration with the help of OTECP and accompanying antiarrhythmic therapy (AAT) was carried out in 59 patients with diseases of the cardiovascular system aged 40 to 77 years. The duration of AF before pacing was 35.93 ± 5.25 days. The efficiency of OTECP was 71.19%, and the time for spontaneous SR restoration was on average 16.92 ± 2.67 h. During pacing, the combined AAT has no advantages over monotherapy, despite its higher efficiency before OTECP. The obtained results indicate that the duration of AF prior to the OTECP procedure did not affect either the effectiveness of the procedure or the timing of spontaneous SR restoration. Inadequate control of blood pressure during treatment was a risk factor for reducing the effectiveness of OTECP, and contributed to the persistence or recurrence of arrhythmia. In patients with AF without AH, a decrease in left ventricular contractility and severe grade of CHF with an increase in left ventricular chamber dimension at end systole, a decrease in ejection fraction (EF) and fractional shortening (FS), reduces the likelihood of spontaneous SR restoration after OTECP, while additional administration of digoxin to increase myocardial contractility did not influence the effectiveness the therapy being carried out. The enlarged dimensions of the left atrium, which did not go beyond the critical dimensions, also had no influence on the effectiveness of the therapy. The efficiency of SR restoration against the background of AAT was 71.19%. Taking into account the EEC accompanied by the treatment performed corresponds to 83.05%. The effectiveness of OTECP when performed on the background of mono- or combined AAT did not differ significantly and amounted to 70.83 and 71.43%, as well as the terms of spontaneous SR restoration — 16.94 ± 2.86 and 16.89 ± 2, 48 hours respectively. The effectiveness of OTECP during mono- or combined AAT was 70.83% and 71.43%, respectively, and the time for spontaneous SR restoration was 16.94 ± 2.86 and 16.89 ± 2.48 hours. Medicamentous cardioversion of AF prior to the OTECP procedure is effective in 54.29% of cases and only with the combined AAT.
A RARE CASE OF BLADDER CANCER METASTASIS TO THE PENIS
Authors:   Novosibirsk State Medical University, Fedorenko V.N. ,   City Clinical Hospital No. 1,   Novosibirsk Regional Clinical Oncology Center, Novosibirsk, Russia, Udalov K.V. ,   Novosibirsk State Medical University; City Clinical Hospital No. 1, Novosibirsk, Russia, Feofilov I.V. ,   Novosibirsk State Medical University; State Novosibirsk Regional Clinical Hospital, Novosibirsk, Russia, Fedorenko A.A. ,   City Clinical Hospital No. 1, Novosibirsk, Russia, Turganova M.V. ,   Novosibirsk Regional Clinical Oncology Center, Novosibirsk, Russia, Cherny S.V. ,   City Clinical Hospital No. 1, Novosibirsk, Russia
Published: December 2022

Tumors of the penis (both malignant and benign) are fairly rare diseases. Even more rare are cases of metastasis of malignant tumors of other organs to penis. The clinical picture of penile metastatic lesions is highly heterogeneous, ranging from small nodules to massive lesions with or without ulceration, obstructive or irritative symptoms, hematuria or priapism. This article reviews the literature on this rare nosology, as well as from personal experience presents a clinical observation of a rare disease: priapism secondary to bladder cancer metastasis.
Coronary artery disease with intermediate coronary artery stenosis. Clinical peculiarities. The chronological age and biological age ratio
Authors:   Novosibirsk State Medical University, Novosibirsk, Russia, Yakhontov D.A. , Ostanina Yu.O. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Lykov A.P. ,   Novosibirsk Tuberculosis Research Institute, Novosibirsk, Russia
Published: December 2022

Introduction. Coronary artery disease (CAD) remains the main cause of disability and mortality among working-age people. A significant part of stable angina patients are patients with intermediate (40–70%) coronary artery stenosis. Aim. To study cardiovascular risk factors and make a comparative assessment of the clinical angiographic picture and vascular stiffness in stable angina patients with intermediate coronary artery stenosis, depending on the chronological age / biological age ratio, as well as to determine the level of long-term metabolites of nitric oxide (NO) – nitrites (NO2) . Materials and methods. 40 stable angina class I–III patients (36 men) aged 33–68 years with intermediate coronary artery stenosis were examined. Depending on the values of the chronological age / biological age coefficient (K), the patients were divided into two groups. The 1st group included patients with a biological age exceeding the passport age (K < 1.0 [0.53; 0.98]), the 2nd group included patients with a biological age equal or inferior to the chronological age (K ≥ 1.0 [1.1; 1.5], p < 0.01 ). Results. Stable angina patients with intermediate coronary artery stenosis represent a rather challenging group of people in terms of prognosis. Patients with increased biological age are characterized by an unfavorable course of the disease and a less favorable cardiometabolic profile compared to patients whose biological age corresponded to the chronological one. At the same time, the level of long-term metabolites of nitric oxide (NO) – nitrites (NO2) in plasma did not depend on the biological age of patients. Conclusion. The study of the biological age and level of long-term metabolites of nitric oxide (NO) – nitrites (NO2)in stable CAD patients with intermediate coronary artery stenosis is of great interest and requires further research.
Analysis of the provision of medicines to beneficiary categories of citizens in the Novosibirsk Region
Authors:   Novosibirsk State Medical University, Novosibirsk, Russia, Dzhuparov A.S. , Ibragimova G.Ya. ,   Bashkir State Medical University, Ufa, Russia, Dzhuparova I.A. ,   Novosibirsk State Medical University, Novosibirsk, Russia
Published: December 2022

Introduction. Despite the significant financial resources for pharmaceutical care in the constituent entities of the Russian Federation, differences remain in ensuring the availability of drugs to the citizens eligible for social support. In this regard, the development of organizational and pharmaceutical measures to optimize the system of subsidized provision of medicines for the population (in the example of the Novosibirsk Region (NR)) is an important area of modern pharmaceutical science. Aim. Analysis of the provision of medicines to beneficiaries in the Novosibirsk Region. Materials and methods. The sources of information were materials of the Novosiboblpharm, State Public Institution of Novosibirsk Region, the database of the Novosibirskoblpharm on the cost and number of provided and defferred prescriptions during 2019–2021 for 35 municipal entities (MEs) of the NR. Content analysis, expert assessment method, logical, non-parametric (rank), economic and statistical, and cluster analysis were used. Results. Monitoring of the number of citizens, eligible to receive medicines on preferential terms for the analyzed period in the federal segment revealed an increase in beneficiaries by 13.96%, and in the regional segment – a decrease by 5.19%. Analysis of the number and cost of provided prescriptions and medicines supplied during this period showed that pharmaceutical care to regional beneficiaries has improved, while to federal beneficiaries – worsened in all indices. As a result of an assessment of structural similarity of the Provision of Essential Medicines (PEM), during 2019–2021, the territorial systems of subsidized provision of medicines of MEs of the NR were separated into the federal and the regional segments. It was found that in the federal segment, only 18 (51.4%) MEs in 2019, 20 (57.14%) MEs in 2021 of 35 MEs of the NR have a rational structure of subsidized provision of medicines, and the increase was 11.16%. In the regional segment, only 21 (60.0%) MEs in 2019, 22 (62.80%) MEs in 2021 of 35 MEs in the NR had a rational structure of subsidized provision of medicines, the increase was 4.76%. Conclusion. An irrational structure of subsidized provision of medicines has been identified, which consists in its substantial structural similarity in clusters, and asymmetry in the federal and regional segments, that requires an in-depth research and revision of the subsidized provision of medicines structure, substantiation of new directions for the future development of the PEM system.
Comparative evaluation of logistic regression and decision tree in predicting multidrug-resistant tuberculosis recurrence
Authors:   Tomsk Tuberculosis Medical Center, Tomsk, Russia, Alliluev A.S. , Filinyuk O.V. ,   Siberian State Medical University, Tomsk, Russia, Аksenov S.V. ,   Siberian State Medical University; Tomsk Polytechnic University, Tomsk, Russia, Shnayder E.E. ,   Tomsk Tuberculosis Medical Center, Tomsk, Russia, Filinyuk D.E. ,   Tomsk Polytechnic University, Tomsk, Russia, Loginova Yu.A. ,   Siberian State Medical University, Tomsk, Russia
Published: December 2022

Introduction. The rate of recurrence of respiratory tuberculosis is one of the indicators characterizing the effectiveness of anti-tuberculosis measures. Timely detection of patients with relapses is one of the priority approaches in solving the problem. Currently, with the introduction of big data processing technologies, namely artificial intelligence, various classifiers are used that take into account the totality of signs identified in patients. The decision tree algorithm has proven itself widely in medical analytics. By analyzing these data, it is possible to classify the state of health and identify the first signs of tuberculosis recurrence. Aim. To develop and evaluate models for predicting a recurrence in patients with pulmonary tuberculosis caused by multidrug-resistant pathogen (MDR-TB), using logistic regression and decision tree. Materials and methods. The study included clinical and epidemiological, age, sex, social, medical and biological data of 346 patients with MDR-TB who successfully completed chemotherapy. Two observation groups were formed depending on the onset of recurrence of the disease in patients at least in the five-year follow-up period. The first group consisted of 35 patients with relapse, and the second one had 311 patients with no relapse. Statistical data processing for logistic regression was performed by IBM SPSS Statistics 23.0, the decision tree classifier was designed in the Scikit-learn 0.24.2 library in an interactive cloud environment with the Google Colaboratory code, using K-fold stratified validation. The quantitative interpretation of the prediction results was carried out according to the ROC-curves (receiver operating characteristic) with the assessment of the AUC indicator (the area under the ROC-curve). Results. The sensitivity and specificity of the logistic regression model and the decision tree classifier for predicting tuberculosis recurrence were 98.7%, 88.6% and 74.0%, 97.0%, respectively. Conclusion. The created models can become a tool for predicting the recurrence of MDR-TB in cured patients.
Alternative Methods of Therapy of Nausea and Vomiting of Pregnant Women
Authors:   Federal State Educational Institution of Higher Education “Kazan (Volga region) Federal University”, Zhelezova M.E. ,   Kazan, Russian Federation, Sharipova R.I. ,   Federal State Educational Institution of Higher Education “Kazan (Volga region) Federal University”; Kazan, Russian Federation
Published: December 2022

Study Objective: Evaluation of the effectiveness of ginger extract in the treatment of nausea and vomiting light and moderate range of pregnant women. Study Design: Observational study. Materials and Methods. The research included 56 pregnant women with symptoms of nausea and vomiting: at the first visit they had complaints of nausea and/or vomiting being 6–16 weeks pregnant. The severity of nausea and vomiting was assessed on the Pregnancy- Unique Quantification of Emesis and Nausea scale before the start of therapy, on days 4 and 7 of treatment. The pregnant women were divided into two groups. The main group consisted of 28 women who took the dietary supplement Preginor, a comparison group — 28 patients who were given only recommendations for lifestyle and diet modification. Among 56 pregnant women who were studied, there 36 were with light symptoms of nausea and vomiting (18 women from the main group and 18 in the comparison group); 20 pregnant women had a moderate degree of nausea and vomiting (10 patients from the main group, 10 from the comparison group). Preginor contains a highly selective ginger root extract (67 mg) standardized to 5% gingerols, which corresponds to about 1 g of fresh ginger; vitamin B6 1.4 mg, magnesium lactate 112.5 mg. Study Results. Relief of symptoms of nausea and vomiting in pregnant women who took ginger was on average 48 hours faster compared to patients who received only recommendations for lifestyle and diet modification: after 3,3 (0,5) and 5,1 (1,2) days, respectively (t = –5,60, p = 0.000). With a moderate course of nausea and vomiting, taking ginger also helped to alleviate the condition in the majority of patients (80%). Conclusion. Preginor is an effective non-pharmacological remedy for the relief of symptoms of nausea and vomiting of pregnant women. It is advisable to recommend the dietary supplement Preginor for widespread introduction into clinical practice, raising the awareness of medical personnel and patients about its effectiveness and safety. Keywords: vomiting, nausea, hyperemesis gravidarum, ginger extract.
The Role of Platelets in the Formation of Immunological Tolerance in Recurrent Miscarriage
Authors:   FSBI “National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov” Ministry of Healthcare of the Russian Federation, Zhukova A.S. ,   Moscow, Russian Federation, Vanko L.V. ,   FSBI “National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov” Ministry of Healthcare of the Russian Federation; Moscow, Russian Federation, Krechetova L.V. ,   FSBI “National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov” Ministry of Healthcare of the Russian Federation; Moscow, Russian Federation, Khoroshkeeva O.V. ,   FSBI “National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov” Ministry of Healthcare of the Russian Federation; Moscow, Russian Federation, Tetruashvili N.K. ,   FSBI “National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov” Ministry of Healthcare of the Russian Federation; Moscow, Russian Federation
Published: December 2022

Objective of the Review: Аnalysis of literature and summarizing of data on the participation of platelets in the formation of immunological tolerance during the physiological pregnancy and recurrent miscarriage. Key points. Platelet-derived soluble factors determine their involvement in the endocrine regulation of the placenta, initiate and maintain trophoblast invasion. Platelets are able to influence the balance of M1 and M2 macrophages, inhibit the cytotoxic potential of NK cells and the antigen-presenting ability of dendritic cells. The interaction of platelets with regulatory T cells initiates the recruitment of lymphocyte cells to the site of inflammation and their activation. It has been shown that the differentiation of immune cells and changes in their functional activity, aimed at creating conditions favorable for prolonging pregnancy, are largely determined by both platelet-derived soluble factors and the formation of platelet-leukocyte complexes. Conclusion. Platelets and products of their activation play an important role in creating the conditions necessary for the onset of pregnancy and its prolongation to full term. The functional state of platelets determines the success of placentation both directly (through the control of hemodynamic parameters in the placental vessels, increased invasiveness of the extracellular trophoblast, the effect on the endocrine background) and indirectly by modulating the functions of decidual immune cells, which determines their contribution in the implementation of idiopathic pregnancy loss. Keywords: platelets, platelet-leukocyte interaction, immunoregulation, recurrent abortion, pregnancy loss.
Efficacy of Dydrogesterone in Threatened Miscarriage: a Systematic Review and Meta-analysis
Authors:   FSBI “National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov” Ministry of Healthcare of the Russian Federation, Tetruashvili N.K. ,   Moscow, Russian Federation, Shih E.V. ,   Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University); Moscow, Russian Federation
Published: December 2022

Objective of the Review: To review all studies using dydrogesterone in threatened miscarriage and to evaluate the effect of dydrogesterone treatment on miscarriage rates in women with miscarriage. Key points. Many years of experience in many clinical studies confirm that progestogens contribute to the preservation of pregnancy in the event of a threatened miscarriage. Dydrogesterone and progesterone are the most suitable progestogens for pregnant women. The high result of dydrogesterone in high-risk pregnancy is due to its chemical structure. This systematic review and meta-analysis includes data only from randomized trials, in particular those based on comparisons of dydrogesterone with placebo. The results demonstrate that in the group of patients treated with dydrogesterone, the frequency of miscarriages was statistically significantly lower than in the group of patients treated with placebo. These findings correlate with previous data from meta-analyses and reviews of randomized clinical trials in 2017–2021, where dydrogesterone also significantly reduced the risk of pregnancy loss in threatened and recurrent miscarriage. Moreover, the largest direct comparative randomized study IPD LOTUS (2020) demonstrated a higher efficacy of dydrogesterone compared to micronized vaginal progesterone. Conclusion. According to the results of this systematic review and meta-analysis of randomized clinical trials based on the comparison of dydrogesterone with placebo, in the group of patients who received dydrogesterone, the frequency of miscarriages was statisticallysignificantly lower than in the group of patients who received placebo. The use of dydrogesterone is not only justified, but an essential component of the treatment of recurrent pregnancy loss. Keywords: miscarriage, recurrent pregnancy loss, habitual miscarriage, progestagens, dydrogesterone, progesterone.
Pengoptimalan Penggunaan Smartphone Sebagai Digital Marketing Pada SMAN 14 Bekasi
Authors: Dina Atika Prima , Nidaul Khasanah Fata , Herlawati  , Sari Rafika , Retnoningsih Endang , Trias Handayanto Rahmadya , Sri Lestari Tyastuti
Published: December 2022

Penggunaan internet untuk aktivitas transaksi bisnis dikenal dengan istilah Electronic Commerce (E-commerce). Hal ini ditandai dengan meningkatnya jumlah pengusaha yang menggunakan e-commerce dalam perusahaannya. Digital marketing memudahkan pebisnis memantau dan menyediakan segala kebutuhan dan keinginan calon konsumen, di sisi lain calon konsumen juga bisa mencari dan mendapatkan informasi produk hanya dengan cara menjelajah dunia maya sehingga mempermudah proses pencariannya. Mitra dari kegiatan pengabdian kepada masyarakat yaitu guru SMA Negeri 14 Bekasi. Hal ini dilakukan sebagai upaya pengenalan dalam pengoptimalan penggunaan smartphone yang tidak hanya digunakan untuk sekedar menulis pesan, melakukan panggilan dan bersosial media saja, namun dapat juga dijadikan sebagai media yang mampu mendukung kegiatan usaha atau bisnis yang dimiliki oleh beberapa Guru. Pelaksanaannya materi yang dipaparkan mengenai pengantar digital marketing dan teknis penggunaan salah satu ­e-commerce Shopee. Metode pelaksanaan kegiatan ini dimulai dari penyuluhan, pelatihan dan evaluasi. Hasil dari kegiatan pelatihan menunjukkan para peserta antusias dengan adanya kegiatan ini dan menganggap materi yang dipaparkan sangat menarik dan bermanfaat.
As fontes em estudos pombalinos: ocorrências em livros e publicações em periódicos
Authors: Silva Nayara Stefanie Mandarino , Santos Elaine Maria
Published: December 2022

As pesquisas que abordam o período pombalino aparecem, na historiografia da educação no Brasil, em um baixo volume, além de serem marcadas por diversas representações, frequentemente dicotômicas. Nesse sentido, surge a necessidade de uma renovação nos estudos pombalinos. Esta pesquisa[1] busca contribuir com esse propósito, uma vez que objetiva fazer o levantamento das fontes utilizadas em livros e publicações em periódicos por autores brasileiros. Foram encontrados 245 textos, que tiveram suas referências analisadas e classificadas, com base nos conjuntos propostos por Alves (2005), em: obras clássicas, fontes documentais e historiografia, que foi subdividida em teses e dissertações, publicações em periódicos e livros, dicionários e biografias. A historiografia, especialmente livros, concentra o maior número de recorrências nos trabalhos analisados. Percebeu-se, ainda, que poucos autores estudam fontes documentais.
Palavras-chave: Colônia. Fontes históricas. Historiografia brasileira.
 
[1] Este texto apresenta resultados da pesquisa de iniciação científica “O Marquês de Pombal e a instrução pública”, realizada entre 2019 e 2020 na Universidade Federal de Sergipe.
Knowledge and practices of open science among scholars and researchers in Tanzania
Authors: David Aneth Bella , Alimohamed Mohamed , Paul  , Modern Grantina , Buhomoli Obadia Shadrack
Published: December 2022

The Open Science (OS) movement has been spreading rapidly among researchers with positive outcomes on accessibility of scientific knowledge. However, there is no clear evidence on the level of awareness and types of OS practices among scholars and researchers in Tanzania, potentially missing an opportunity to reap the rewards of the movement to scholarly pursuits. This study investigated the level of awareness of OS and practices among Tanzanian scholars and researchers. Findings of a digital survey conducted for three months and recruited 144 respondents, show a high level of awareness of the term OS for 84% of respondents, most of them having encountered it from peers or online sources including social media. About 69% of respondents were male while about 44% of respondents were early career professionals. Open access (OA) publishing was the most common OS activity practised by respondents, highlighting both the need to create awareness on other practices and an entry point for knowledge expansion. However, respondents highlighted the barriers to spreading of the OS movement in the country including lack of awareness, knowledge and skills, the lack of institutional support and concerns over data security and ownership. Findings of this study establish OA as the most common and important OS practice among Tanzanian scholars. They show the importance of online resources and peers to peer learning and in spreading OS awareness. The study also reveals several areas of advocacy and including setting supportive institutional policies and building infrastructure to support OS practices. We recomment establisment of robust guidelines, institutional support and clear opportunities to incentivize individuals to adopt OS practices ao as to achieve the momentum required to scale the movement beyond OA.
USE OF MATHEMATICAL MODELS OF THE THEORY OF QUEUING SYSTEMS FOR DESCRIPTION AND ANALYSIS OF WASTE MANAGEMENT SYSTEMS IN MEGA CITIES
Authors:   St. Petersburg State University of Aerospace Instrumentation, Rubinov V. V.
Published: December 2022

The relevance of organizing an effective waste management system in the modern world is beyond doubt. It must be understood that waste can be not only a source of environmental hazard, but also a means of making a profit and secondary material resources. The area of waste management is most dependent on the transport system, that is, it is most sensitive to the organization of effective transport work. The article describes the modern technological process of working with waste. The principles and acts regulating the detail are described. Mathematical models describing the modern process of working with waste at the level of routes are considered. Problems in the practical plane are defined. The possibility of describing the system through the theory of queuing systems is estimated. The types of queuing systems at different levels of planning applicable to the description of the waste management system are determined. The range of problems that can be solved through the theory of the queuing system is determined. Directions for further research in this area are determined.