bluuebunny/crossref_metadata_2025 huggingface dataset:
СУЧАСНИЙ СТАН МЕНЕДЖМЕНТУ ТА ЛІДЕРСТВА В ОРГАНІЗАЦІЙНО-ПСИХОЛОГІЧНОМУ ВИМІРІ: КРИТИКА ТЕОРІЇ ТА АНАЛІЗ ЕМПІРИЧНИХ ДАНИХ
Authors: Куций О. А.
Published: February 2023

Стаття містить інформацію про практичне організаційно-психологічне дослідження. Воно має міждисциплінарну системну основу, проводиться понад 2 роки й відбувається збір емпіричних даних за розробленою методикою з оцінки гуманітарної складової організації. Методика має 30 критеріїв оцінки й це дає можливість системно дослідити функціонування 3 механізмів та 10 компонентів організації за гуманітарним аспектом. Здійснено математичну обробку статистичної бази даних за 208 українськими організаціями за вказаною методикою за менеджментом та лідерством. Ці явища в методиці застосовано в якості компонентів. Було застосовано кореляційний аналіз за непараметричним парним критерієм Кендала. Встановлено наявність дуже великої кількості незначних показників кореляції. Через це було сконцентровано увагу та узагальнено інформацію на тих моментах, де кореляції не було. Такий підхід було обґрунтовано тим, що в організації як системному явищі мають бути зв’язки між її компонентами. Відсутність зв’язків є ознакою проблеми функціонування системи як єдиного цілого. Встановлено, що лідерство як синергетична властивість соціальної групи недостатньо реалізована в процесах управління людськими ресурсами та розвитку організації. Однак, лідерство, за винятком участі в конфліктах, впливає досягнення ефекту синергії в організації. За менеджментом виокремлено проблеми досягнення ефекту синергії через цінності, традиції та імідж. При цьому, більша проблема в менеджменті за розвитком організації. Розроблена методика з оцінки гуманітарної складової організації за 30 критеріями ще раз підтвердила можливість її застосування на практиці. Її можна вдосконалювати чи доповнювати, але ідея застосування є реальною для практичного використання та переходу науки на практичний бік розвитку.
Biomanufacturing of melatonin is now possible
Authors: Yang Lei , Palsson Bernhard O
Published: March 2023

Currently, the majority of the melatonin manufactured is chemically synthesized replacing the previous method that extracted it from biological materials. Due to environmental concerns, biomanufacturing of chemical-related products is now gaining favor over chemical synthesis. Melatonin is synthesized from tryptophan in a four-step pathway that includes a hydroxylase and methyl transferase, both representing major challenges for metabolic engineering. Using novel technologies, including genome editing and laboratory evolution, the metabolic pathway of melatonin synthesis has been reconstructed in a microbial host which has the capacity to produce melatonin in gram-level quantities.
Analisis Visual Penerapan Brand Equity Pada Video City Branding "Shining Batu"
Authors: Warsaa Yogi Widya Saka , Kabelen Nicholaus Wayong
Published: March 2023

Objek penelitian adalah video city branding Kota Batu yaitu video berjudul ”Shining Batu” yang di publikasikan oleh Pemerintah Kota Batu guna mendukung kegiatan branding diantaranya untuk promosi mengenalkan kepada starget audience untuk datang ke Kota Batu hingga menciptakan citra bahwa Kota Batu yang diwakilkan dengan City Branding ”Shining Batu” adalah destinasi wisata yang memiliki berbagai tempat untuk berlibur, untuk wisata kuliner hingga wisata alam dan wisata buatan. Penelitian ini berujuan untuk mengukur dan mengetahui brand equity dalam kegiatan branding yang disampaikan dalam video ”Shining Batu”. Dalam penelitian ini menggunakan metode kualitatif yang mana kan membahas dari segi kualitas audio dan visual dari segi penyajian setiap footage yang divisualkan dan dikorelasikan dengan city branding Pemerintah Kota Batu yaitu ”Shining Batu”. Hasil penelitian ini berupa beberapa analisis yang dikaitkan dengan disiplin ilmu desain komunikasi visual khususnya ilmu branding dan videografi.
Effect of the clenching of teeth on the posture: differences between bruxer′s and unbruxer′s population
Authors: Siffre M. , Bertucci W. , Soudain-Pineau M.
Published: February 2023

Objectives. Relying on the Thegosis theory, the purpose of this study is to analyze the effects of the clenching of teeth on the posture with a stabilometric platform.

Method. Thirty-two subjects divided into two groups, Bruxism and Control using criteria from O. F. Molina and al., have passed two series of three stabilometric measures: unclenched teeth then clenched teeth. Posturological parameters analyzed in this study are: X-moyen, Y-moyen, Surface, LFS, VFY.

Results. Statistical analysis of the data reveals significant differences for the X-moyen, the Surface and the VFY. Conclusion. This study shows that if unclenched teeth, bruxer subjects have a similar posture to the control subjects, clenched teeth have different postures and clenching of teeth tends to stabilize the bruxers and destabilize the control subjects.
Czynniki sukcesu negocjacji zdalnych
Authors: Masłoń-Oracz Anna , Pietrzak Maria
Published: March 2023

Negocjacje stanowią ważny aspekt życia społecznego oraz gospodarczego. Wprawnym negocjatorom możemy zawdzięczać koniec wojny albo jej zapobiegnięcie, a także wiele innych korzystnych rozwiązań różnego rodzaju konfliktów. Wraz z początkiem pandemii niemożność spotkania się partnerów negocjacyjnych na żywo, twarzą w twarz, skłoniło przedsiębiorstwa, ale też inne podmioty, do sięgnięcia po aplikacje umożliwiające prowadzenie negocjacji w formule zdalnej, czyli na odległość. Celem artykułu jest zidentyfikowanie kluczowych czynników sukcesu negocjacji zdalnych, by wskazać dobre praktyki w tym zakresie, a także zidentyfikować te obszary, którymi różnią się negocjacje stacjonarne od zdalnych. Przeprowadzone badanie miało charakter jakościowy i polegało na badaniu ankietowym próby celowej. Wybrano do niej osoby, dla których negocjacje stanowią istotny element życia zawodowego. Główny wniosek płynący z badań skłania do stwierdzenia, że czynniki sukcesu negocjacji zdalnych są zasadniczo takie same, jak stacjonarnych, przy czym większej staranności należy dołożyć w kwestii technologii – zarówno własnych umiejętności w zakresie obsługi sprzętu, jak też zapewnienia odpowiedniej jakości infrastruktury.
The Rise of the New Korea Democratic Party in the 1985 National Assembly Election in South Korea
Authors:   Korean Association For Political And Diplomatic History, Kang Won-Taek , Jeong Jin-uk
Published: March 2023

This article explores the causes of the unexpected rise of the New Korea Democratic Party (NKDP). In the 1985 National Assembly election, a new party, NKDP emerged as the main opposition party, which led to the collapse of the party system manufactured by the authoritarian regime. We argue that the election results primarily aimed at restructuring the ‘opposition bloc’. The election results were less related with public outcry against the Chun Doo-hwan regime or as a punishment for the ruling Democratic Justice Party. However, the election provided a critical opportunity for the regime-challenging NKDP to unite with young people who were the vanguard of political resistance to the authoritarian regime. In that sense, the 1985 election gave an important momentum for the pro-democracy movement later. In addition, social and economic changes such as urbanization, the rise of young voters in the demographic structure, and the mass production of ‘highly educated voters’ were also important factors for the rise of the NKDP in the 1985 election.
Vulnerable People or Vulnerable Borders?
Authors: Walter Kathrin Marie
Published: February 2023

The concept of vulnerability is blurred and often evoked in the context of refugee and forced migrant women. Paradoxically, it is also employed by the EU with regard to its external border security. Thus, the question arises of how the EU conceptualizes vulnerability in its external migration policies and who is perceived to be vulnerable – refugees and migrants, or external borders? Using a systematic lexical keyword search to identify relevant policy aims in the EU Pact on Migration and Asylum, the latest policy agenda on migration and asylum of the EU Commission published in September 2020, this paper highlights the mostly one-dimensional concept of vulnerability in external EU policies. In this article, it is argued that this entails significant gendered implications for asylum-seekers and migrants en route to Europe. It further reveals the detrimental effects for migrants and refugees caused by the EU’s focus and prioritization of its vulnerable borders. Ultimately, this paper by adopting a gendered lens calls into question whether the European Commission fully incorporates human rights commitments in its policy guidance on asylum and migration.
The Implications of Turkish Interventions in Rojava for US and EU Foreign Policies
Authors: Dag Veysi
Published: March 2023

This paper examines how Turkish invasions into Northern Syria’s Kurdish enclave undermine US and European policy objectives. It argues that the Turkish state, obsessed with Kurdish hostility, endangers American and European foreign policies by further destabilising war-torn Syria, facilitating the empowerment of Islamist extremist groups, impeding a peaceful resolution to Syria’s protracted conflict, and assisting Russia’s anti-Western interests. The paper suggests that the US and Europe could rather deploy a dual strategy aimed at exerting pressure on Turkey to discontinue its disruptive and belligerent actions. To cease targeting anti-ISIS Kurdish forces, Turkey must either resume the Kurdish-Turkish peace process or risk being designated as a rival state, analogous to Russia, and subjected to punitive sanctions.
ОСОБЛИВОСТІ ЕМОЦІЙНО-ВОЛЬОВОЇ СФЕРИ ФАХІВЦІВ ІНКЛЮЗИВНОГО НАВЧАННЯ
Authors: Нікітіна Оксана , Білоцерківська Юлія , Колчигіна Анна , Дацун Галина
Published: March 2023

У статті визначена актуальність впровадження інклюзивного навчання. Проаналізовані психологічні засади успішної реалізації інклюзивної освіти, а саме визначено емоційно-вольові особливості актуальних та потенційних фахівців інклюзивного навчання. Здійснено теоретико-методологічний огляд проблем інклюзивного навчання щодо особистості фахівця в сучасних освітніх умовах. Визначені компоненти процесу формування та розвитку професійної компетентності фахівця, що працює в умовах інклюзивної освіти. Сформовано психодіагностичний комплекс емпіричного дослідження емоційно-вольової сфери фахівців інклюзивного навчання. Проаналізовані відмінності у стилі саморегуляції поведінки, мотивації професійної кар'єрі, мотивації досягнення, вольової регуляції та емоційного вигорання актуальних та потенційних фахівців інклюзивного навчання. Визначені актуальні напрямки психокорекційноїроботи. Визначено, що особистість педагога є стрижневою ланкою в імплементації засад інклюзивності.
Changes in the VARK Learning Style from the First to the Second Preclinical Year of Medical Students: A Follow-up Cross-sectional Questionnaire Study in a Thai Medical School
Authors: Maprapho Punyapat , Sitticharoon Chantacha , Maikaew Pailin , Lertsiripatarajit Vasu , Keadkraichaiwat Issarawan , Charoenngam Nipith Charoenngam
Published: March 2023

Objective: This study aimed to determine percentage of students who changed (change group) and did not change (no-change group) in the visual (V)–aural (A)–reading/writing (R)–kinesthetic (K) learning style from the first (Preclinic1) to the second (Preclinic2) preclinical year; and compare academic performance (GPA, percentile of GPA, and achievement of study targets) and stress levels between these groups.

Materials and Methods: The VARK and research questionnaires were sent to students of the 2019 class at the end of Preclinic1 and again at Preclinic2. GPA and percentile of GPA were obtained from academic records while achievement of study targets and stress levels were from the research questionnaires.

Results: Most students were multimodal learners (65.03% in Preclinic1 and 69.51% in Preclinic2). From Preclinic1 to Preclinic2, 69.3% of students changed and 30.7% of students did not change their learning preference. In Preclinic1 and Preclinic2, GPA and percentile of GPA were higher in the no-change compared with the change group (p<0.01 all). GPA in the change group was lower in Preclinic2 than that in Preclinic1 (p<0.001). Achievement of study targets and stress levels of the change group in Preclinic2 were lower than theirs in Preclinic1 and those of the no-change group in Preclinic2 (p<0.05 all). The students who changed their learning preference might need to adapt to their new learning preference probably leading to lower academic capability but less stress.

Conclusion: Students changed their learning preference around 70% from Preclinic1 to Preclinic2. The change group exhibited lower academic capability but less stress.
Emotion Regulation and Behavioral Problems in Children with Autism Spectrum Disorder: A University Hospital Based Cross-Sectional Study
Authors: Hosiri Tikumporn , Sittanomai Napat , Bumrungtrakul Thanchanok , Boon-yasidhi Vitharon
Published: March 2023

Objective: The objectives of this study were to investigate behavioral problems and emotion regulation in children with autism spectrum disorder (ASD) with and without psychiatric comorbidities, and to assess the correlation between emotion regulation and behavioral problems.

Materials and Methods: Participants included 65 children with ASD (ASD group) and 65 children with ASD and psychiatric comorbidities (ASD+CPD group), aged 6 to 12, and their caretakers. Emotion regulation was assessed by the Emotion Regulation Checklist (ERC). Behavioral problems were assessed by the Strengths and Difficulties Questionnaire (SDQ).

Results: An independent sample T-test revealed that the ASD+CPD group had poorer emotion regulation, greater emotion lability/negativity, and a higher total difficulty score when compared to the ASD group. The Pearson’s Correlation Coefficient indicated that emotion regulation (r = -0.47, p<0.05) and lability/negativity (r = 0.65, p<0.05) correlated with the total difficulties score of the SDQ. A multiple regression analysis revealed that lower emotion regulation and higher emotion lability/negativity predicted an increase in behavioral problems (R2 = 0.44, p<0.05).

Conclusions: We found that children with ASD and psychiatric comorbidities had poorer emotion regulation and more behavioral problems than those without comorbidities, and that poorer emotion regulation predicts behavioral problems. These results indicate that children with ASD should be assessed for psychiatric comorbidities, particularly those who have emotional dysregulation and behavioral problems.
Predictive Factors of Intravesical Recurrence after Ureteroscopy in Upper Urinary Tract Urothelial Carcinoma Followed by Radical Nephroureterectomy
Authors: Srinualnad Sittiporn , Sawangchareon Atichet , Jongjitaree Kantima , Phinthusophon Kittipong , Taweemonkongsap Tawatchai , Leewansangtong Sunai , Nualyong Chaiyong , Liangkobkit Karn , Chotikawanich Ekkarin
Published: March 2023

Objective: To investigate the risk factors of developing intravesical recurrence (IVR) in patients with upper urinary tract urothelial carcinoma (UTUC) who underwent ureterorenoscopy (URS) before radical nephroureterectomy with bladder cuff excision (RNU).

Materials and Methods: This retrospective study collected data from the medical records of patients diagnosed with UTUC between January 2012 and December 2019. All the patients underwent ureteroscopy before radical surgery. Patients previously diagnosed with bladder cancer were excluded. A total of 63 patients were included in the study. Tumour factors, such as multiplicity, location, size, histologic grade, pathologic T-stage, and lymphovascular invasion status, were evaluated. The type of endoscopic procedure and time interval between URS and RNU were analysed to determine the factors affecting IVR.

Results: The associated factors with IVR included multifocal tumours (HR = 4.8(1.9–11.9)), large size tumours greater than or equal to 4 cm (HR = 3.3(1.5–7.0)), and time interval greater than or equal to 5 weeks between URS and RNU (HR = 2.6(1.2–5.5)). Factors including tumour location (kidney or ureter), size, grading, T-stage, and lymphovascular invasion as well as the type of endoscopic procedure were not at high risk for IVR.

Conclusion: The predictive factors of IVR for UTUC patients who underwent URS before RNU included a multiplicity of primary tumours and a tumour size greater than or equal to 4 cm, while a time interval between URS and RNU greater than or equal to 5 weeks increased the risk of IVR.
Efecto antibacteriano de la sangre de drago en cultivos in vitro en cepas bacterianas ATCC
Authors: Tualombo Masabanda Víctor Álvaro , Castillo Hidalgo Edy Paul
Published: March 2023

Objetivo. El objetivo de la investigación fue evaluar el efecto antibacteriano de la sangre de drago (Crotón lechleri) en cultivos in vitro de cepas bacterianas ATCC; Staphylococcus aureus ATCC 25923 y Escherichia coli ATCC 25922, a diferentes concentraciones 1%, 2%, 4%, 6%, 8%, 16%, 80%, 90% y 100%. Materiales y métodos. Se realizó un total 54 cultivos, de los cuales 27 cultivos corresponden al análisis de extracto Sangre de drago (Crotón lechleri) en distintas concentraciones frente a Staphylococcus aureus ATCC 25923 y 27 cultivos al análisis del extracto Sangre de drago (Crotón lechleri) frente a la bacteria Escherichia coli ATCC 25922, donde se aplicó 3 repeticiones para cada tratamiento. Resultados. En los resultados no se observó ningún halo de inhibición de los discos de sensibilidad preparados en diferentes concentraciones por lo que se consideran las cepas bacterianas ATCC; Staphylococcus aureus 25923 y Escherichia coli 25922, no presentan sensibilidad a la sangre de drago (Crotón lechleri). Conclusiones. De los resultados obtenidos podemos concluir que la sangre de drago (Crotón lechleri) no presenta actividad antibacteriana para las cepas de cepas bacterianas ATCC; Staphylococcus aureus 25923 y Escherichia coli 25922.
Geomechanical substantiation of parameters for safe completion of mining the coal reserves adjacent to main workings
Authors: Bondarenko V. I , Symanovych H. A , Kovalevska I. A , Shyshov M. V , Yakovenko V. H
Published: February 2023

Purpose. Geomechanical substantiation of the parameters for conducting stope operations, ensuring the operational state of main workings. Methodology. The research is performed using an algorithm which includes the sequential execution of interrelated stages: analysis of mining-geological and mining-technical conditions for maintaining the network of main workings; mine observations of their state with the identification of specifics of rock pressure manifestations and predicting the probable negative consequences of conducting stope operations in the immediate vicinity; preliminary substantiation of possible technological options for mining the coal seam, taking into account the preservation of operational state of main workings. Scientific calculations for determining the most expedient option are based on the development of geomechanical models of the rock mass behavior around the main workings when mining the adjacent extraction site; analysis of the mass stress-strain state with the prediction of probable rock pressure manifestations; development of recommendations for limiting (or completely eliminating) the negative consequences of conducting stope operations near main workings. The above algorithm of actions uses a combination of experimental mine research methods with technologies for performing computational experiments based on the finite element method. Findings. A systematic analysis of the mining-geological and mining-technical conditions for maintaining the network of main workings has been performed, the results of which are used to substantiate ideas about the mechanism for the occurrence of specifics of rock pressure manifestations, recorded during instrumental observations of their state. Three options have been developed for completing the mining of the extraction site adjacent to the mine horizon main workings. For each of them, a geomechanical model has been constructed for calculating the stress-strain state of the adjacent coal-bearing mass. Its analysis makes it possible to formulate a number of recommendations regarding the rational parameters for conducting stope operations, as well as structural and technological solutions to increase the stability of the main workings and maintain the conditions for their safe operation. Originality. New dependences of influence of the extraction sites on the main working network stability depending on the texture and mechanical properties of lithotypes have been obtained based on the research on the stress-strain state of a weakly metamorphosed mass. For the first time, geomechanical models have been developed of the mutual influence of main workings on the parameters for conducting stope operations. Practical value. The presented recommendations simultaneously reduce the loss of coal reserves and preserve the network of main workings in proper operational state.
Reducing external air leakage at the main ventilation unit of the mine
Authors: Stolbchenko O. V , Yurchenko A. A , Luts I. O , Saveliev D. V
Published: February 2023

Purpose. To increase the efficiency of mine ventilation by reducing external leaks through the ventilation shaft construction. To achieve this goal, it is necessary to solve the following tasks: - to analyse the existing methods for reducing external leaks through the ventilation shaft components; - consider the possibility of using a counteracting fan to unload the main fan from external leaks; - to establish the mutual influence of the main and counteracting fans during their joint operation; - to develop a methodology for determining the operating mode of the auxiliary fan in which external leaks are stopped in full. Methodology. To accomplish the set tasks, the analysis of the existing methods for combating external leaks in the main fan of the mine was carried out; a mathematical model was developed for controlling the ventilation modes of the main and auxiliary fans during their joint operation. Based on the mathematical model, the degree of mutual influence of the fans on each other was studied, a technique was developed for determining their mode, in which the mine jet in full volume enters the main fan, and external leaks are stopped by the auxiliary fan. Findings. A mathematical model for controlling mine ventilation and stopping external leaks in the ventilation shaft elements has been developed using the methods for planning industrial experiments; the degree of mutual influence of the fans on each other has been established; a method has been developed for determining the mode of their joint operation, in which the main fan is not loaded with external leaks. Originality. The degree of mutual influence of the main and auxiliary fans during their joint operation has been determined. The conditions are studied under which the mine jet enters the main fan, while external leaks occur to the auxiliary fan. Practical value. The studies conducted make it possible to separate external leaks from the main stream coming out from the mine, which increases the safety of work and reduces the cost of ventilating the mine.
Orchidaceae em um fragmento de Mata de Cipó em Poções, Bahia
Authors: Lima Clara Elís de Oliveira , Azevedo Cecília Oliveira de
Published: March 2023

Orchidaceae ainda é pouco estudada no Sudoeste da Bahia, sendo que a maioria dos estudos existentes foram realizados nos municípios de Boa Nova e Vitória da Conquista. Desta forma, o presente estudo teve como objetivo realizar o levantamento da família Orchidaceae em um fragmento de Floresta Estacional Decidual Montana, localizado em Salitre, zona rural do município de Poções, Bahia, Brasil. O levantamento foi realizado através de excursões mensais realizadas entre setembro de 2020 e maio de 2022. Foram encontradas 20 espécies de orquídeas distribuídas em 15 gêneros, incluindo duas novas ocorrências para o Nordeste do país: Maxillaria chrysantha Barb.Rodr. e Zygostates juliae Campacci & C.R.M.Silva, uma nova ocorrência para o estado da Bahia: Campylocentrum fasciola (Lindl.) Cogn. e quatro para o Sudoeste da Bahia, Cattleya cernua (Lindl.) Van den Berg, Masdevallia infracta Lindl. e Ornithocephalus myrticola Lindl., contribuindo desta forma para o conhecimento da flora local, do estado da Bahia e da região Nordeste do Brasil.
Entregadores por aplicativo e a Covid-19: Uma entrega destinada ao Poder Legislativo
Authors: Soares Aline Gil Pereira
Published: February 2023

Enquanto muitas formas de trabalho se reinventaram durante a pandemia decorrente da Covid-19, o trabalho de entrega por aplicativo aumentou consideravelmente devido às medidas de restrição comercial e isolamento social. A situação de calamidade pública, somada à precariedade do trabalho por plataforma e a ausência de uma regulação da profissão desencadearam os chamados “Breques dos Apps”. A organização coletiva dos entregadores exerceu papel importante no exercício de pressão ao poder público por garantias básicas e direitos à categoria que durante a pandemia evidenciou ainda mais sua essencialidade. O presente artigo é fruto de uma pesquisa documental realizada nas principais casas legislativas localizadas no Distrito Federal, junto a entrevistas com os principais atores na luta dos entregadores por aplicativo identificados no processo de monitoramento. O objetivo da pesquisa é observar de que forma o pleito da categoria dos entregadores por aplicativo, bem como suas condições de trabalho foram abordadas pelo Poder Legislativo durante a pandemia.
The Saints of the Crisis: Larnaudie and Stiegler in the Oversight Committee Room
Authors: Watt Calum
Published: March 2023

Continuing the examination of different strategies for putting the financial crisis in images, this chapter shows how two writers – the novelist Mathieu Larnaudie and the late philosopher Bernard Stiegler – understand the financial crash as marking the collapse of faith in a certain ideological fiction: that of the self-regulating free market. The primary focus is on the place of images in Larnaudie’s novel Les Effondrés (2010), which consists of short chapters (but long sentences) recounting in a stream-of-consciousness style the fates of the principal actors of the crisis. Les Effondrés offers a series of tableaux in which many of these figures undergo a kind of transvaluation in which a habitual relation to the market passing through images (via trading terminals or stock indices, for example) is broken. I examine not only how Larnaudie relates the manner in which the crisis manifests itself as a mediatised event, but also how Larnaudie derives a literary text across media from the images of the crisis (official government speeches and inquiries, press cuttings and other images) and thus shows how we live in a world of ‘derivative images’.
Derivative Films
Authors: Watt Calum
Published: March 2023

Developing the notion of the filmic derivation broached in the previous chapters, Chapter 5 analyses three experimental films relating to the financial crash: The Fountainhead (2010) by Société Réaliste, who were a Paris-based artist cooperative, now dissolved; Film Socialisme (2010) by Jean-Luc Godard; and Film Catastrophe (2018) by Paul Grivas. These three films are in contextual terms films of the 2008 crash and are in stylistic terms ‘derivative films’; that is, films which are in large part derived from and which reconfigure other films and media, collapsing the relation between original and derivative into one of a general iconomy.
Population Structure, Exploitation Status, and Prospects of Brown Meagre Sciaena umbra Linnaeus, 1758 From the Turkish Coast of the Black Sea
Authors: BODUR Barış , AYDIN Mehmet , KARADURMUŞ Uğur
Published: March 2023

The brown meagre (Sciaena umbra Linnaeus, 1758) population has experienced dramatic population declines, and it was regionally assessed as “Near Threatened” in the Mediterranean. In this study, the current status of brown meagre populations in the Black Sea was evaluated by estimating growth and mortality rates based on age readings from the otolith. All specimens were collected by commercial trammel nets between March 2019 and February 2020 in the Turkish coast of the Black Sea. A total of 324 brown meagre were sampled during the study period, ranging in age from 0 to 26. The peak spawning season of the species was from June to July. The Von Bertalanffy growth parameters of (L∞ = 54.15, k = 0.14 yr-1, t0 = -3.11) supports previous studies and suggests that brown meagre is a long-lived and slow-growing species. The exploitation ratio of 0.53 for females and 0.47 for males. Life-history features and mortalities indicate that the brown meagre has relatively high fertility but may be undefended to intense fishing pressure. However, the impact of overfishing, pollution and climate change can have increasingly detrimental effects on the overall population size of this population.
PEMBUATAN SISTEM PREDIKSI PERSEDIAAN BARANG PADA TOKO NABILA MENGGUNAKAN METODE WEIGHTED MOVING AVERAGE DAN REORDER POINT
Authors: Nafa Nabila El Indri  , Henni Endah Wahanani
Published: March 2023

Toko Nabila merupakan sebuah toko yang bergerak dibidang penjualan baik helm, alat tulis kantor (ATK), maupun perabot rumah tangga. Proses pengelolaan persediaan barang di Toko Nabila baik pemeriksaan maupun pencatatan masih dilakukan secara manual sehingga kurang efektif dan efisien juga beresiko terjadi catatan hilang atau rusak. Terdapat banyak jenis barang di Toko Nabila. Hal ini tentu sangat menyulitkan pemilik toko dalam memperkirakan jumlah kebutuhan dari setiap jenis barang yang harus dipesan. Permasalahan yang terjadi di Toko Nabila adalah kesulitan dalam menentukan jumlah barang yang harus tersedia untuk bulan berikutnya agar tetap dapat memenuhi kebutuhan pelanggan dan tidak menyebabkan penumpukan barang dalam jangka waktu yang lama. Pada penelitian pembuatan sistem prediksi persediaan barang ini menggunakan metode weighted moving average untuk memperoleh informasi mengenai prediksi persediaan barang pada periode mendatang dan reorder point untuk mengetahui kapan waktu yang tepat untuk melakukan pemesanan persediaan barang kembali di Toko Nabila. Pembuatan sistem prediksi persediaan barang berbasis web dibutuhkan untuk menjawab permasalahan yang terdapat di Toko Nabila. Pengujian hasil akurasi prediksi sistem pada penelitian ini menggunakan MAD, MSE, dan MAPE. Nilai rata-rata MAD, MSE, dan MAPE untuk 10 data prediksi persediaan barang adalah 7,44, 77,99, dan 31,90.
Implementasi Augmented Reality Pada Aplikasi Pengenalan Objek Wisata Di Kota Ambon
Authors: Irene Samar
Published: March 2023

Kota Ambon yang dikenal dengan sebutan “Ambon Manise” merupakan salah satu pulau di indonesia yang juga memliki wisata alam yang tidak kalah menarik. Dengan keindahan alam yang ada seharusnya menjadi potensi wisata yang menarik untuk dikunjungi wisatawan lokal maupun mancanegara. Hingga saat ini informasi wisata kota Ambon hanya terdapat pada website ataupun blog. Dibutuhkan inovasi dalam mengenalkan objek wisata yang membantu meningkatkan kunjungan wisatawan dan mampu untuk mengenalkan tempat wisata kota Ambon di setiap kalangan. Hal ini membutuhkan teknologi Augmented Reality yang menggabungkan objek virtual 2D dan/atau 3D dengan lingkungan nyata dan dapat digunakan pada perangkat seluler berbasis android. Aplikasi yang penulis buat berisikan informasi wisata yang mencakup objek, video, lokasi dan puzzle wisata. Objek wisata dikemas dalam bentuk multimedia dengan teknik Augmented Reality metode markerless sehingga terlihat lebih interaktif dan dapat digunakan sebagai sarana pengenalan objek wisata di kota Ambon pada masyarakat. Hasil dari aplikasi ini adalah aplikasi Augmented Reality menggunakan metode markerless yang mampu menampilkan objek wisata 3D tanpa menggunakan marker khusus pada perangkat android. Metode markerless ini dapat mendeteksi objek dengan rentang jarak minimal 10 cm dan jarak maksimal 100 cm dan berdasarkan pengujian menggunakan kuesioner, dari 22 responden sebanyak 89,77% menyatakan aplikasi berdampak besar dalam mengenalkan wisata Ambon.
PREDIKSI PRODUKSI DOMPET KULIT SINTETIS MENGGUNAKAN METODE FUZZY MAMDANI
Authors: Surohadi Mochamad , Hindarto Hindarto , Setiawan Hamzah
Published: March 2023

UMKM PDKT merupakan suatu usaha mikro kecil menengah yang bergerak di bidang produksi dompet di Kecamatan Tanggulangin Kabupaten Sidoarjo. UMKM ini memproduksi dompet dengan jumlah penjualan berkisar antara 35.000-40.000 pecs/tahun. Pada saat ini dompet menjadi salah satu kebutuan yang wajib dimiliki oleh laki – laki maupun perempuan. oleh karena itu produk si dompet sangat sulit di prediksi termasuk oleh usaha mikro kecil menengah produksi dompet khas tanggulangin. Perencanaan pengambilan keputusan UMKM PDKT dalam menentukan jumlah produk sangatlah penting untuk memaksimalkan keuntungan, dalam hal ini perencanaan produksi bergantung pada sisa persediaan dari satu periode sebelumnya dan juga perkiraan jumlah permintaan pada satu periode selanjutnya. Permintaan konsumen yang semakin banyak mengharuskan proses produksi di lakukan secara efisien. Logika Fuzzy merupakan salah satu ilmu yang dapat menganalisa ketidakpastian. Dengan metode Mamdani atau yang biasa disebut metode Min-Max dari dua atau lebih variabel liunguistik. Tujuan dari penelitian ini adalah untuk memprediksi jumlah produksi dompet kulit sintetis menggunakan logika fuzzy metode mamdani dengan 4 tahapan yaitu; 1)Fuzzyfikasi; 2)Aturan; 3)Aplikasi Fungsi Implikasi; 4)Defuzzyfikasi, dari hasil defuzzifikasi inilah kita bisa menentukan keputusan yang akan diambil.
TOPIC GROUPING BASED ON DESCRIPTION TEXT IN MICROSOFT RESEARCH VIDEO DESCRIPTION CORPUS DATA USING FASTTEXT, PCA AND K-MEANS CLUSTERING
Authors: Ayatullah Ahmad Hafidh , Suciati Nanik
Published: March 2023

Video data retrieval can be done based on voice, image, or text data that represents video content. Searching for videos using text data can be done by calculating the similarity between the text descriptions provided by the user and the text descriptions of all the video data in the database. Only video data with a certain level of similarity will be provided to the user as a fetch result. Determining the similarity of the description text can be based on the clustering results of the feature representation of the description text with the word embedding used. This research groups topics of the Microsoft Research Video Description Corpus (MRVDC) based on text descriptions of Indonesian language dataset. The Microsoft Research Video Description Corpus (MRVDC) is a video dataset developed by Microsoft Research, which contains paraphrased event expressions in English and other languages. The results of grouping these topics show how the patterns of similarity and interrelationships between text descriptions from different video data, which will be useful for the topic-based video retrieval. The topic grouping process is based on text descriptions using fastText as word embedding, PCA as features reduction method and K[1]means as the clustering method. The experiment on 1959 videos with 43753 text descriptions to vary the number of k and with/without PCA result that the optimal clustering number is 180 with silhouette coefficient of 0.123115. The optimal clustering results in this study can be used for video data retrieval systems in the Indonesian language MRVDC dataset.
Engineered exosomes derived from miR-132-overexpresssing adipose stem cells promoted diabetic wound healing and skin reconstruction
Authors: Ge Lifeng , Wang Kangyan , Lin Hang , Tao Endong , Xia Weijie , Wang Fulin , Mao Cong , Feng Yongzeng
Published: March 2023

The tissue reconstruction of diabetic wounds mainly depends on the proliferation and remodelling of cutaneous cells around wounds and the transplantation of random skin flaps, however, the proliferation of cells or survival of skin flaps are difficult due to the severe inflammation and other problems caused by diabetes. The stem cell-derived exosomes loaded with miRNA can be an effective therapeutic strategy for promoting diabetic wound healing. Therefore, in this study, the engineered exosomes derived from miR-132-overexpressing adipose stem cells (miR-132-exo) was obtained for promoting the healing of diabetic wounds and skin flaps. In vitro, the miR-132-exo promoted the proliferation and migration of human umbilical vein endothelial cells (HUVECs). In vivo, streptozotocin (STZ) induced diabetic mice were used to create full-thickness skin wounds and random skin flaps to further investigate the healing effect of miR-132-exo. The results showed miR-132-exo evidently enhanced the survival of skin flaps and promote diabetic wound healing, through reducing local inflammation, promoting angiogenesis and stimulating M2-macrophages polarization mediated by NF-κB signaling pathway. These novel findings demonstrated that engineered miR-132-exo can be a potent therapeutic for treating diabetic wounds and inflammatory-related disease.
Self-assembling peptides as immunomodulatory biomaterials
Authors: Hernandez Andrea , Hartgerink Jeffrey D. , Young Simon
Published: March 2023

Self-assembling peptides are a type of biomaterial rapidly emerging in the fields of biomedicine and material sciences due to their promise in biocompatibility and effectiveness at controlled release. These self-assembling peptides can form diverse nanostructures in response to molecular interactions, making them versatile materials. Once assembled, the peptides can mimic biological functions and provide a combinatorial delivery of therapeutics such as cytokines and drugs. These self-assembling peptides are showing success in biomedical settings yet face unique challenges that must be addressed to be widely applied in the clinic. Herein, we describe self-assembling peptides’ characteristics and current applications in immunomodulatory therapeutics.
Role of MSC‐derived small extracellular vesicles in tissue repair and regeneration
Authors: Aguiar Koga Bruna Andrade , Fernandes Letícia Alves , Fratini Paula , Sogayar Mari Cleide , Carreira Ana Claudia Oliveira
Published: March 2023

Mesenchymal stem cells (MSCs) are crucial for tissue homeostasis and repair, secreting vesicles to the extracellular environment. Isolated exosomes were shown to affect angiogenesis, immunomodulation and tissue regeneration. Numerous efforts have been dedicated to describe the mechanism of action of these extracellular vesicles (EVs) and guarantee their safety, since the final aim is their therapeutic application in the clinic. The major advantage of applying MSC-derived EVs is their low or inexistent immunogenicity, prompting their use as drug delivery or therapeutic agents, as well as wound healing, different cancer types, and inflammatory processes in the neurological and cardiovascular systems. MSC-derived EVs display no vascular obstruction effects or apparent adverse effects. Their nano-size ensures their passage through the blood–brain barrier, demonstrating no cytotoxic or immunogenic effects. Several in vitro tests have been conducted with EVs obtained from different sources to understand their biology, molecular content, signaling pathways, and mechanisms of action. Application of EVs to human therapies has recently become a reality, with clinical trials being conducted to treat Alzheimer’s disease, retina degeneration, and COVID-19 patients. Herein, we describe and compare the different extracellular vesicles isolation methods and therapeutic applications regarding the tissue repair and regeneration process, presenting the latest clinical trial reports.
Functional optimization of light-activatable Opto-GPCRs: Illuminating the importance of the proximal C-terminus in G-protein specificity
Authors: Leemann Siri , Kleinlogel Sonja
Published: March 2023

Introduction: G-protein coupled receptors (GPCRs) are the largest family of human receptors that transmit signals from natural ligands and pharmaceutical drugs into essentially every physiological process. One main characteristic of G-protein coupled receptors is their ability to specifically couple with different families of G-proteins, thereby triggering specific downstream signaling pathways. While an abundance of structural information is available on G-protein coupled receptorn interactions with G-proteins, little is known about the G-protein coupled receptor domains functionally mediating G-protein specificity, in particular the proximal C-terminus, the structure which cannot be predicted with high confidentiality due to its flexibility.

Methods: In this study, we exploited OptoGPCR chimeras between lightgated G-protein coupled receptors (opsins) and ligand-gated G-protein coupled receptors to systematically investigate the involvement of the C-terminus steering G-protein specificity. We employed rhodopsin-beta2-adrenoceptor and melanopsin-mGluR6 chimeras in second messenger assays and developed structural models of the chimeras.

Results: We discovered a dominant role of the proximal C-terminus, dictating G-protein selectivity in the melanopsin-mGluR6 chimera, whereas it is the intracellular loop 3, which steers G-protein tropism in the rhodopsin-beta2-adrenoceptor. From the functional results and structural predictions, melanopsin and mGluR6 use a different mechanism to bovine rhodopsin and b2AR to couple to a selective G-protein.

Discussion: Collectively, this work adds knowledge to the G-protein coupled receptor domains mediating G-protein selectivity, ultimately paving the way to optogenetically elicited specific G-protein signaling on demand.
Aberrant lipid accumulation in the mouse visceral yolk sac resulting from maternal diabetes and obesity
Authors: Zhang Man , Salbaum J. Michael , Jones Sydney , Burk David , Kappen Claudia
Published: March 2023

Maternal diabetes and obesity in pregnancy are well-known risk factors for structural birth defects, including neural tube defects and congenital heart defects. Progeny from affected pregnancies are also predisposed to developing cardiometabolic disease in later life. Based upon in vitro embryo cultures of rat embryos, it was postulated that nutrient uptake by the yolk sac is deficient in diabetic pregnancies. In contrast, using two independent mouse models of maternal diabetes, and a high-fat diet-feeding model of maternal obesity, we observed excessive lipid accumulation at 8.5 days in the yolk sac. The numbers as well as sizes of intracellular lipid droplets were increased in yolk sacs of embryos from diabetic and obese pregnancies. Maternal metabolic disease did not affect expression of lipid transporter proteins, including ApoA1, ApoB and SR-B1, consistent with our earlier report that expression of glucose and fatty acid transporter genes was also unchanged in diabetic pregnancy-derived yolk sacs. Colocalization of lipid droplets with lysosomes was significantly reduced in the yolk sacs from diabetic and obese pregnancies compared to yolk sacs from normal pregnancies. We therefore conclude that processing of lipids is defective in pregnancies affected by maternal metabolic disease, which may lead to reduced availability of lipids to the developing embryo. The possible implications of insufficient supply of lipids -and potentially of other nutrients-to the embryos experiencing adverse pregnancy conditions are discussed.
Extracellular vesicles from medicated plasma of Buyang Huanwu decoction-preconditioned neural stem cells accelerate neurological recovery following ischemic stroke
Authors: Long Jun , Gu Chenyang , Zhang Qiankun , Liu Jiale , Huang Jiajun , Li Yajing , Zhang Yifan , Li Rong , Ahmed Waqas , Zhang Jianfeng , Khan Ahsan Ali , Cai Hengsen , Hu Yong , Chen Lukui
Published: March 2023

Introduction: The neurological impairment of survivors after ischemic stroke poses a serious risk to their quality of life and health. Effective therapeutic options are still lacking. Neural stem cells (NSCs) promote neurogenesis via secreted extracellular vesicles (NSC-EVs), which would be a potential therapeutic option, but the insufficient quantity of NSC-EVs in vivo restrains clinical application. Buyang Huanwu Decoction (BHD), a classic traditional Chinese medicine (TCM) decoction, is promising to alleviate neurological impairment after ischemic stroke. It was speculated that BHD might promote neurological recovery through the NSC-EVs.

Methods: The medicated plasma of BHD (MP-BHD) was prepared to precondition NSCs and isolate EVs (BHD-NSC-EVs). Middle cerebral artery occlusion (MCAO) models and primary NSCs were administered to evaluate the therapeutic effect. Next-generation sequencing was performed to explore the mechanism.

Results: The BHD-NSC-EVs more significantly accelerated neurological recovery after MCAO and promoted NSCs proliferation and differentiation than BHD and NSC-EVs alone. MP-BHD enhanced the largescale generation of BHD-NSC-EVs, which encapsulated functional miRNA and may play critical roles in neurogenesis.

Discussion: In replacing BHD or NSCs, the preconditioned NSC-EVs present a more efficient therapeutic strategy for ischemic stroke. Based on the clinical efficacy of TCM, the preconditioning of NSC-derived EVs via the MP of TCM herbs would presents a newly promising therapeutic strategy for neurological diseases.
Sec22b-dependent antigen cross-presentation is a significant contributor of T cell priming during infection with the parasite Trypanosoma cruzi
Authors: Biscari Lucía , Maza Ma Carmen , Farré Cecilia , Kaufman Cintia Daniela , Amigorena Sebastian , Fresno Manuel , Gironès Núria , Alloatti Andrés
Published: March 2023

Antigen cross-presentation is a vital mechanism of dendritic cells and other antigen presenting cells to orchestrate the priming of cytotoxic responses towards killing of infected or cancer cells. In this process, exogenous antigens are internalized by dendritic cells, processed, loaded onto MHC class I molecules and presented to CD8+ T cells to activate them. Sec22b is an ER-Golgi Intermediate Compartment resident SNARE protein that, in partnership with sintaxin4, coordinates the recruitment of the transporter associated with antigen processing protein and the peptide loading complex to phagosomes, where antigenic peptides that have been proteolyzed in the cytosol are loaded in MHC class I molecules and transported to the cell membrane. The silencing of Sec22b in dendritic cells primary cultures and conditionally in dendritic cells of C57BL/6 mice, critically impairs antigen cross-presentation, but neither affects other antigen presentation routes nor cytokine production and secretion. Mice with Sec22b conditionally silenced in dendritic cells (Sec22b−/−) show deficient priming of CD8+ T lymphocytes, fail to control tumor growth, and are resistant to anti-checkpoint immunotherapy. In this work, we show that Sec22b−/− mice elicit a deficient specific CD8+ T cell response when challenged with sublethal doses of Trypanosoma cruzi trypomastigotes that is associated with increased blood parasitemia and diminished survival.