bluuebunny/crossref_metadata_2025 huggingface dataset:
Discrimination in In-Patient Geriatric Care: A Qualitative Study on the Experiences of Employees with a Turkish Migration Background
Authors: Ulusoy Nazan , Schablon Anja
Published: March 2020

In most studies, nurses with a migrant background report experiences of interpersonal discrimination. These often occur in interaction with those in need of care. However, in Germany this topic has remained largely unexplored, although a large proportion of the employees in geriatric care have a migration background. The aim of the study was to investigate whether care workers with Turkish migration background in in-patient geriatric care are exposed to discrimination from residents. Furthermore, the reasons for discrimination, handling of discrimination and recommendations for in-patient geriatric facilities to avoid/reduce discrimination were examined. In a qualitative, explorative study, 24 employees with Turkish migrant background working in in-patient geriatric care were interviewed in 2017. The semi-structured interviews were evaluated using a qualitative content analysis according to Mayring. The majority (N = 20) experienced or observed discrimination. This occurred mainly in the form of xenophobic insults and rejections. They perceived visible traits (dark hair and eye color, clothing) as potential reasons. To deal with the discrimination, most of them temporarily left the scene. They recommend that institutions should primarily make the diversity of the workforce transparent to avoid/reduce discrimination. More research is needed about discrimination against care workers with migration background because discrimination may have serious psychological effects that impact employee retention and the quality of care.
Effect of Gig Workers’ Psychological Contract Fulfillment on Their Task Performance in a Sharing Economy—A Perspective from the Mediation of Organizational Identification and the Moderation of Length of Service
Authors: Liu Wenlong , He Changqing , Jiang Yi , Ji Rongrong , Zhai Xuesong
Published: March 2020

Workers’ isolation may occur in gig employment in the sharing economy, which generates a weak perception of the organization and unpredictable work performance. Drawing on social exchange theory, this paper proposes a framework to explore the effect of psychological contract fulfillment on gig workers’ task performance from the perspective of the mediation of organizational identification and the moderation of the length of service. A total of 223 samples were recruited from Didi (a ride-hailing company in China) drivers. The results show that both transactional and relational psychological contract fulfillment can directly affect gig workers’ task performance and also indirectly affect it via organizational identification. When the length of service for the current company is taken into consideration, transactional contract fulfillment, as the representation of a company’s recognition of gig workers’ effort, has a stronger effect on the organizational identification of gig workers who have been working for the company for less than a year compared with those who have been working for a longer period. The results show no difference in the relationship between relational psychological contract and organizational identification between the two groups. Transactional psychological contract fulfillment exhibits the same significant effect on gig workers’ task performance in both groups. By contrast, relational psychological contract fulfillment has a stronger effect on long-serving Didi drivers than on those who joined the company within the year. These findings generate certain theoretical and practical implications for gig employment management in the sharing economy.
Quantification Method for the Uncertainty of Matching Point Distribution on 3D Reconstruction
Authors: Bian Yuxia , Liu Xuejun , Wang Meizhen , Liu Hongji , Fang Shuhong , Yu Liang
Published: March 2020

Matching points are the direct data sources of the fundamental matrix, camera parameters, and point cloud calculation. Thus, their uncertainty has a direct influence on the quality of image-based 3D reconstruction and is dependent on the number, accuracy, and distribution of the matching points. This study mainly focuses on the uncertainty of matching point distribution. First, horizontal dilution of precision (HDOP) is used to quantify the feature point distribution in the overlapping region of multiple images. Then, the quantization method is constructed. H D O P ∗ ¯ , the average of 2 × arctan ( H D O P × n 5 − 1 ) / π on all images, is utilized to measure the uncertainty of matching point distribution on 3D reconstruction. Finally, simulated and real scene experiments were performed to describe and verify the rationality of the proposed method. We found that the relationship between H D O P ∗ ¯ and the matching point distribution in this study was consistent with that between matching point distribution and 3D reconstruction. Consequently, it may be a feasible method to predict the quality of 3D reconstruction by calculating the uncertainty of matching point distribution.
The Relationship between Near-Repeat Street Robbery and the Environment: Evidence from Malmö, Sweden
Authors: Rasmusson Markus , Helbich Marco
Published: March 2020

Near-repeat crime refers to a pattern whereby one crime event is soon followed by a similar crime event at a nearby location. Existing research on near-repeat crime patterns is inconclusive about where near-repeat patterns emerge and which physical and social factors influence them. The present research addressed this gap by examining the relationship between initiator events (i.e., the first event in a near-repeat pattern) and environmental characteristics to estimate where near-repeat patterns are most likely to emerge. A two-step analysis was undertaken using data on street robberies reported in Malmö, Sweden, for the years 2006–15. After determining near-repeat patterns, we assessed the correlations between initiator events and criminogenic places and socioeconomic indicators using a negative binomial regression at a street segment level. Our results show that both criminogenic places and socioeconomic indicators have a significant influence on the spatial variation of initiator events, suggesting that environmental characteristics can be used to explain the emergence of near-repeat patterns. Law enforcement agencies can utilize the findings in efforts to prevent further street robberies from occurring.
Correction: Li, P. et al. Mechanical Characteristics, In Vitro Degradation, Cytotoxicity, and Antibacterial Evaluation of Zn-4.0Ag Alloy as a Biodegradable Material. Int. J. Mol. Sci. 2018, 19, 755
Authors: Li Ping , Schille Christine , Schweizer Ernst , Rupp Frank , Heiss Alexander , Legner Claudia , Klotz Ulrich E. , Geis-Gerstorfer Jürgen , Scheideler Lutz
Published: March 2020

The authors wish to make the following corrections to this paper [...]
Fast-Acting and Receptor-Mediated Regulation of Neuronal Signaling Pathways by Copaiba Essential Oil
Authors: Urasaki Yasuyo , Beaumont Cody , Workman Michelle , Talbot Jeffery N. , Hill David K. , Le Thuc T.
Published: March 2020

This study examined the biological activities of copaiba essential oil via measurement of its effects on signaling pathways in the SH-SY5Y neuronal cell line. Nanofluidic proteomic technologies were deployed to measure the phosphorylation of biomarker proteins within the signaling cascades. Interestingly, copaiba essential oil upregulated the pI3K/Akt/mTOR, MAPK, and JAK/STAT signaling pathways in neuronal cells. The effects of copaiba essential oil peaked at 30 min post-treatment, with a half-maximal effective concentration (EC50) of approximately 80 ng/mL. Treatment with cannabinoid receptor 2 (CB2) agonist AM1241 or the inverse agonist BML190 abrogated the regulatory effects of copaiba essential oil on the pI3K/Akt/mTOR signaling pathway. Surprisingly, copaiba essential oil also activated the apoptosis signaling pathway and reduced the viability of SH-SY5Y cells with an EC50 of approximately 400 ng/mL. Furthermore, β-caryophyllene, a principal constituent of copaiba essential oil, downregulated the pI3K/Akt/mTOR signaling pathway. Taken together, the findings indicated that copaiba essential oil upregulated signaling pathways associated with cell metabolism, growth, immunity, and apoptosis. The biological activities of copaiba essential oil were determined to be fast acting, CB2 mediated, and dependent on multiple chemical constituents of the oil. Nanofluidic proteomics provided a powerful means to assess the biological activities of copaiba essential oil.
Combining Molecular Dynamics and Docking Simulations to Develop Targeted Protocols for Performing Optimized Virtual Screening Campaigns on the hTRPM8 Channel
Authors: Talarico Carmine , Gervasoni Silvia , Manelfi Candida , Pedretti Alessandro , Vistoli Giulio , Beccari Andrea R.
Published: March 2020

Background: There is an increasing interest in TRPM8 ligands of medicinal interest, the rational design of which can be nowadays supported by structure-based in silico studies based on the recently resolved TRPM8 structures. Methods: The study involves the generation of a reliable hTRPM8 homology model, the reliability of which was assessed by a 1.0 μs MD simulation which was also used to generate multiple receptor conformations for the following structure-based virtual screening (VS) campaigns; docking simulations utilized different programs and involved all monomers of the selected frames; the so computed docking scores were combined by consensus approaches based on the EFO algorithm. Results: The obtained models revealed very satisfactory performances; LiGen™ provided the best results among the tested docking programs; the combination of docking results from the four monomers elicited a markedly beneficial effect on the computed consensus models. Conclusions: The generated hTRPM8 model appears to be amenable for successful structure-based VS studies; cross-talk modulating effects between interacting monomers on the binding sites can be accounted for by combining docking simulations as performed on all the monomers; this strategy can have general applicability for docking simulations involving quaternary protein structures with multiple identical binding pockets.
Thymosin β4 Identified by Transcriptomic Analysis from HF Anagen to Telogen Promotes Proliferation of SHF-DPCs in Albas Cashmere Goat
Authors: Dai Bai , Hao Fei , Xu Teng , Zhu Bing , Ren Li-Qing , Han Xiao-Yu , Liu Dong-Jun
Published: March 2020

Increasing cashmere yield is one of the important goals of cashmere goat breeding. To achieve this goal, we screened the key genes that can improve cashmere performance. In this study, we used the RNA raw datasets of the skin and dermal papilla cells of secondary hair follicle (SHF-DPCs) samples of hair follicle (HF) anagen and telogen of Albas cashmere goats and identified a set of significant differentially expressed genes (DEGs). To explore potential associations between gene sets and SHF growth features and to identify candidate genes, we detected functional enrichment and constructed protein-protein interaction (PPI) networks. Through comprehensive analysis, we selected Thymosin β4 (Tβ4), Rho GTPase activating protein 6 (ARHGAP6), ADAM metallopeptidase with thrombospondin type 1 motif 15, (ADAMTS15), Chordin (CHRD), and SPARC (Osteonectin), cwcv and kazal-like domains proteoglycan 1 (SPOCK1) as candidate genes. Gene set enrichment analysis (GSEA) for these genes revealed Tβ4 and ARHGAP6 have a close association with the growth and development of SHF-DPCs. However, the expression of Tβ4 in the anagen was higher than that in the telogen, so we finally chose Tβ4 as the ultimate research object. Overexpressing Tβ4 promoted and silencing Tβ4 inhibited the proliferation of SHF-DPCs. These findings suggest that Tβ4 can promote the growth and development of SHF-DPCs and indicate that this molecule may be a valuable target for increasing cashmere production.
Alveolar Epithelial Type II Cells as Drivers of Lung Fibrosis in Idiopathic Pulmonary Fibrosis
Authors: Parimon Tanyalak , Yao Changfu , Stripp Barry R , Noble Paul W , Chen Peter
Published: March 2020

: Alveolar epithelial type II cells (AT2) are a heterogeneous population that have critical secretory and regenerative roles in the alveolus to maintain lung homeostasis. However, impairment to their normal functional capacity and development of a pro-fibrotic phenotype has been demonstrated to contribute to the development of idiopathic pulmonary fibrosis (IPF). A number of factors contribute to AT2 death and dysfunction. As a mucosal surface, AT2 cells are exposed to environmental stresses that can have lasting effects that contribute to fibrogenesis. Genetical risks have also been identified that can cause AT2 impairment and the development of lung fibrosis. Furthermore, aging is a final factor that adds to the pathogenic changes in AT2 cells. Here, we will discuss the homeostatic role of AT2 cells and the studies that have recently defined the heterogeneity of this population of cells. Furthermore, we will review the mechanisms of AT2 death and dysfunction in the context of lung fibrosis.
FSH for the Treatment of Male Infertility
Authors: Casarini Livio , Crépieux Pascale , Reiter Eric , Lazzaretti Clara , Paradiso Elia , Rochira Vincenzo , Brigante Giulia , Santi Daniele , Simoni Manuela
Published: March 2020

Follicle-stimulating hormone (FSH) supports spermatogenesis acting via its receptor (FSHR), which activates trophic effects in gonadal Sertoli cells. These pathways are targeted by hormonal drugs used for clinical treatment of infertile men, mainly belonging to sub-groups defined as hypogonadotropic hypogonadism or idiopathic infertility. While, in the first case, fertility may be efficiently restored by specific treatments, such as pulsatile gonadotropin releasing hormone (GnRH) or choriogonadotropin (hCG) alone or in combination with FSH, less is known about the efficacy of FSH in supporting the treatment of male idiopathic infertility. This review focuses on the role of FSH in the clinical approach to male reproduction, addressing the state-of-the-art from the little data available and discussing the pharmacological evidence. New compounds, such as allosteric ligands, dually active, chimeric gonadotropins and immunoglobulins, may represent interesting avenues for future personalized, pharmacological approaches to male infertility.
Loricrin: Past, Present, and Future
Authors: Ishitsuka Yosuke , Roop Dennis R.
Published: March 2020

The terminal differentiation of the epidermis is a complex physiological process. During the past few decades, medical genetics has shown that defects in the stratum corneum (SC) permeability barrier cause a myriad of pathological conditions, ranging from common dry skin to lethal ichthyoses. Contrarily, molecular phylogenetics has revealed that amniotes have acquired a specialized form of cytoprotection cornification that provides mechanical resilience to the SC. This superior biochemical property, along with desiccation tolerance, is attributable to the proper formation of the macromolecular protein-lipid complex termed cornified cell envelopes (CE). Cornification largely depends on the peculiar biochemical and biophysical properties of loricrin, which is a major CE component. Despite its quantitative significance, loricrin knockout (LKO) mice have revealed it to be dispensable for the SC permeability barrier. Nevertheless, LKO mice have brought us valuable lessons. It is also becoming evident that absent loricrin affects skin homeostasis more profoundly in many more aspects than previously expected. Through an extensive review of aggregate evidence, we discuss herein the functional significance of the thiol-rich protein loricrin from a biochemical, genetic, pathological, metabolic, or immunological aspect with some theoretical and speculative perspectives.
Could Intravenous Immunoglobulin Collected from Recovered Coronavirus Patients Protect against COVID-19 and Strengthen the Immune System of New Patients?
Authors: Jawhara Samir
Published: March 2020

The emergence of the novel coronavirus in Wuhan, China, which causes severe respiratory tract infections in humans (COVID-19), has become a global health concern. Most coronaviruses infect animals but can evolve into strains that cross the species barrier and infect humans. At the present, there is no single specific vaccine or efficient antiviral therapy against COVID-19. Recently, we showed that intravenous immunoglobulin (IVIg) treatment reduces inflammation of intestinal epithelial cells and eliminates overgrowth of the opportunistic human fungal pathogen Candida albicans in the murine gut. Immunotherapy with IVIg could be employed to neutralize COVID-19. However, the efficacy of IVIg would be better if the immune IgG antibodies were collected from patients who have recovered from COVID-19 in the same city, or the surrounding area, in order to increase the chance of neutralizing the virus. These immune IgG antibodies will be specific against COVID-19 by boosting the immune response in newly infected patients. Different procedures may be used to remove or inactivate any possible pathogens from the plasma of recovered coronavirus patient derived immune IgG, including solvent/detergent, 60 °C heat-treatment, and nanofiltration. Overall, immunotherapy with immune IgG antibodies combined with antiviral drugs may be an alternative treatment against COVID-19 until stronger options such as vaccines are available.
Regenerative Potential of Carbon Monoxide in Adult Neural Circuits of the Central Nervous System
Authors: Jung Eunyoung , Koh Seong-Ho , Yoo Myeongjong , Choi Yoon Kyung
Published: March 2020

Regeneration of adult neural circuits after an injury is limited in the central nervous system (CNS). Heme oxygenase (HO) is an enzyme that produces HO metabolites, such as carbon monoxide (CO), biliverdin and iron by heme degradation. CO may act as a biological signal transduction effector in CNS regeneration by stimulating neuronal intrinsic and extrinsic mechanisms as well as mitochondrial biogenesis. CO may give directions by which the injured neurovascular system switches into regeneration mode by stimulating endogenous neural stem cells and endothelial cells to produce neurons and vessels capable of replacing injured neurons and vessels in the CNS. The present review discusses the regenerative potential of CO in acute and chronic neuroinflammatory diseases of the CNS, such as stroke, traumatic brain injury, multiple sclerosis and Alzheimer’s disease and the role of signaling pathways and neurotrophic factors. CO-mediated facilitation of cellular communications may boost regeneration, consequently forming functional adult neural circuits in CNS injury.
Developing Computational Model to Predict Protein-Protein Interaction Sites Based on the XGBoost Algorithm
Authors: Deng Aijun , Zhang Huan , Wang Wenyan , Zhang Jun , Fan Dingdong , Chen Peng , Wang Bing
Published: March 2020

The study of protein-protein interaction is of great biological significance, and the prediction of protein-protein interaction sites can promote the understanding of cell biological activity and will be helpful for drug development. However, uneven distribution between interaction and non-interaction sites is common because only a small number of protein interactions have been confirmed by experimental techniques, which greatly affects the predictive capability of computational methods. In this work, two imbalanced data processing strategies based on XGBoost algorithm were proposed to re-balance the original dataset from inherent relationship between positive and negative samples for the prediction of protein-protein interaction sites. Herein, a feature extraction method was applied to represent the protein interaction sites based on evolutionary conservatism of proteins, and the influence of overlapping regions of positive and negative samples was considered in prediction performance. Our method showed good prediction performance, such as prediction accuracy of 0.807 and MCC of 0.614, on an original dataset with 10,455 surface residues but only 2297 interface residues. Experimental results demonstrated the effectiveness of our XGBoost-based method.
Vasculoprotective Effects of Vildagliptin. Focus on Atherogenesis
Authors: Wiciński Michał , Górski Karol , Wódkiewicz Eryk , Walczak Maciej , Nowaczewska Magdalena , Malinowski Bartosz
Published: March 2020

Vildagliptin is a representative of Dipeptidyl Peptidase-4 (DPP-4) inhibitors, antihyperglycemic drugs, approved for use as monotherapy and combination therapy in type 2 diabetes mellitus. By inhibiting enzymatic decomposition, DPP-4 inhibitors increase the half-life of incretins such as GLP-1 (Glucagon-like peptide-1) and GIP (Gastric inhibitors polypeptide) and prolong their action. Some studies present results suggesting the anti-sclerotic and vasculoprotective effects of vildagliptin reaching beyond glycemic control. Vildagliptin is able to limit inflammation by suppression of the NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) signaling pathway and proinflammatory agents such as TNF-α (tumor necrosis factor α), IL-1β (Interleukin-1β), and IL-8 (Interleukin 8). Moreover, vildagliptin regulates lipid metabolism; attenuates postprandial hypertriglyceridemia; and lowers serum triglycerides, apolipoprotein B, and blood total cholesterol levels. This DPP-4 inhibitor also reduces macrophage foam cell formation, which plays a key role in atheromatous plaque formation and stability. Vildagliptin reduces vascular stiffness via elevation of nitric oxide synthesis, improves vascular relaxation, and results in reduction in both systolic and diastolic blood pressure. Treatment with vildagliptin lowers the level of PAI-1 presenting possible antithrombotic effect. By affecting the endothelium, inflammation, and lipid metabolism, vildagliptin may affect the development of atherosclerosis at its various stages. The article presents a summary of the studies assessing vasculoprotective effects of vildagliptin with special emphasis on atherogenesis.
Processing Newborn Bloodspot Screening Results for CF
Authors: Barben Jürg , Chudleigh Jane
Published: March 2020

Every newborn bloodspot screening (NBS) result for cystic fibrosis (CF) consists of two parts: a screening part in the laboratory and a clinical part in a CF centre. When introducing an NBS programme, more attention is usually paid to the laboratory part, especially which algorithm is most suitable for the region or the country. However, the clinical part, how a positive screening result is processed, is often underestimated and can have great consequences for the affected child and their parents. A clear algorithm for the diagnostic part in CF centres is also important and influences the performance of a CF NBS programme. The processing of a positive screening result includes the initial information given to the parents, the invitation to the sweat test, what to do if a sweat test fails, information about the results of the sweat test, the inconclusive diagnosis and the carrier status, which is handled differently from country to country. The time until the definitive diagnosis and adequate information is given, is considered by the parents and the CF team as the most important factor. The communication of a positive NBS result is crucial. It is not a singular event but rather a process that includes ensuring the appropriate clinicians are aware of the result and that families are informed in the most efficient and effective manner to facilitate consistent and timely follow-up.
The Governance Approach of Smart City Initiatives. Evidence from Trondheim, Bergen, and Bodø
Authors: Gohari Savis , Ahlers Dirk , F. Nielsen Brita , Junker Eivind
Published: March 2020

A pragmatic and polity-focused solution for governing a smart city in the direction of sustainability is still missing in theory and practice. A debate about whether a smart city is a pragmatic solution for modern challenges or just a technology-led urban utopia is entangled with the vexed issue of governance. While ‘smart governance’ has drawn unprecedented interest, the combination of its conceptual vagueness and broad applications couple with a lack of focus on its underlying international and local political paradigms have raised concerns about its utility. This study contributes to restoring attention to the original concept of governance, its differences with governing and government, and the potential challenges resulting from its functionality in its real, multi-layered, and complex contexts. This paper explores the intellectual connection between governance and smart cities, from both an empirical and a conceptual/analytical perspective. From the empirical side, we examine which actors, processes, and relational mechanisms at different levels that have had an impact on the initiation of smart cities in three Norwegian cities: Trondheim, Bergen, and Bodø. We illustrate how the structural sources of the interests, roles, and power in smart city initiatives have caused governance to emerge and change, but have also affected the goals designed by specific actors.
Shear Thinning in the Prandtl Model and Its Relation to Generalized Newtonian Fluids
Authors: Müser Martin H.
Published: March 2020

The Prandtl model is certainly the simplest and most generic microscopic model describing solid friction. It consists of a single, thermalized atom attached to a spring, which is dragged past a sinusoidal potential representing the surface energy corrugation of a counterface. While it was primarily introduced to rationalize how Coulomb’s friction law can arise from small-scale instabilities, Prandtl argued that his model also describes the shear thinning of liquids. Given its success regarding the interpretation of atomic-force-microscopy experiments, surprisingly little attention has been paid to the question how the Prandtl model relates to fluid rheology. Analyzing its Langevin and Brownian dynamics, we show that the Prandtl model produces friction–velocity relationships, which, converted to a dependence of effective (excess) viscosity on shear rate η ( γ ˙ ) , is strikingly similar to the Carreau–Yasuda (CY) relation, which is obeyed by many non-Newtonian liquids. The two dimensionless parameters in the CY relation are found to span a broad range of values. When thermal energy is small compared to the corrugation of the sinusoidal potential, the leading-order γ ˙ 2 corrections to the equilibrium viscosity only matter in the initial part of the cross-over from Stokes friction to the regime, where η obeys approximately a sublinear power law of 1 / γ ˙ .
Friction and Wear Characteristics of 18Ni(300) Maraging Steel under High-Speed Dry Sliding Conditions
Authors: Sun Kun , Peng Weixiang , Wei Binghui , Yang Longlong , Fang Liang
Published: March 2020

18Ni(300) maraging steel, which has exceptional strength and toughness, is used in the field of aviation and aerospace. In this paper, using a high-speed tribo-tester, tribological behaviors of 18Ni(300) maraging steel were investigated under high-speed dry sliding conditions. Morphology of the worn surfaces and the debris was analyzed by scanning electron microscope, and the oxides of worn surfaces caused by friction heat were detected by X-ray diffraction. The experiment results reveal that the friction coefficient of frictional pairs declines with increasing load and speed. With the speed and load increasing, oxides of the worn surfaces of 18Ni(300) maraging steel change from FeO to Fe3O4 and the wear mechanism converts from adhesive wear into severe oxidative or extrusion wear.
Silver-Nanoparticles Embedded Pyridine-Cholesterol Xerogels as Highly Efficient Catalysts for 4-nitrophenol Reduction
Authors: Shimoga Ganesh , Shin Eun-Jae , Kim Sang-Youn
Published: March 2020

Two xerogels made of 4-pyridyl cholesterol (PC) and silver-nanocomposites (SNCs) thereof have been studied for their efficient reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) in the presence of aqueous sodium borohydride. Since in-situ silver doping will be effective in ethanol and acetone solvents with a PC gelator, two silver-loaded PC xerogels were prepared and successive SNCs were achieved by using an environmentally benign trisodium citrate dehydrate reducing agent. The formed PC xerogels and their SNCs were comprehensively investigated using different physico-chemical techniques, such as field emission scanning electron microscopy (FE-SEM), Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), powdered X-ray diffraction (XRD) and UV-Visible spectroscopy (UV-Vis). The FE-SEM results confirm that the shape of xerogel-covered silver nanoparticles (SNPs) are roughly spherical, with an average size in the range of 30–80 nm. Thermal degradation studies were analyzed via the sensitive graphical Broido’s method using a TGA technique. Both SNC-PC (SNC-PC-X1 and SNC-PC-X2) xerogels showed remarkable catalytic performances, with recyclable conversion efficiency of around 82% after the fourth consecutive run. The apparent rate constant (kapp) of SNC-PC-X1 and SNC-PC-X2 were found to be 6.120 × 10-3 sec-1 and 3.758 × 10-3 sec-1, respectively, at an ambient temperature.
Life Cycle Assessment of the Sustainability of Enhancing the Photodegradation Activity of TiO2 with Metal-Doping
Authors: Fernandes Sónia , Esteves da Silva Joaquim C.G. , Pinto da Silva Luís
Published: March 2020

While TiO2 nanoparticles have shown potential as photocatalysts in the degradation of organic contaminants, their inability to absorb efficiently visible light has limited their industrial application. One strategy for solving this problem is monodoping TiO2 photocatalysts with transition metals, which has worked in the degradation of several pollutants. However, it is not clear if this improvement is enough to offset the potential environmental impacts of adding metal ions to the synthesis of TiO2. Herein, we have used Life Cycle Assessment (LCA) to determine the sustainability of monodoping TiO2 with transition metals (Fe, Co, Mn and Ni, with a 1% weight ratio) to enhance the photocatalytic properties of the photocatalyst toward the degradation of Carbamazepine and Methyl Orange, under UV-A and visible light irradiation. We found that the addition of transition-metals has no significant effect on the environmental impacts associated with the synthesis of TiO2, when a weight-based functional unit was considered. However, when photocatalytic activity was considered, major differences were found. Thus, our results demonstrate that the sustainability of monodoping with different transition metals is solely determined by their ability to enhance (or not) the photocatalytic activity of TiO2. Our data also demonstrated that isopropyl alcohol constitutes a critical point in the synthesis of TiO2 photocatalysts, with ethanol being a potential substitute.
Effect of Grain Size on the Microstructure and Strain Hardening Behavior of Solution Heat-Treated Low-C High-Mn Steel
Authors: Opiela Marek , Fojt-Dymara Gabriela , Grajcar Adam , Borek Wojciech
Published: March 2020

The low-carbon high-Mn austenitic steel microalloyed with titanium was investigated in this work. The steel was solution heat-treated at different temperatures in a range from 900 to 1200 °C. The aim was to receive a different grain size before the static tensile test performed at room temperature. The samples of different grain sizes showed the different strain hardening behavior and resulting mechanical properties. The size of grain diameter below 19 μm was stable up to 1000 °C. Above this temperature, the very enhanced grain growth took place with the grain diameter higher than 220 μm at 1200 °C. This huge grain size at the highest temperature resulted in the premature failure of the sample showing the lowest strength properties at the same time. Correlations between the grain size, the major strengthening mechanism, and fracture behavior were addressed. The relationships were assessed based on microstructural investigations and fractography tests performed for the deformed samples. The best combination of strength and ductility was found for the samples treated at 1000–1100 °C.
Interaction of Different Charged Polymers with Potassium Ions and Their Effect on the Yield Stress of Highly Concentrated Glass Bead Suspensions
Authors: Lu Zichen , Becker Simon , Leinitz Sarah , Schmidt Wolfram , von Klitzing Regine , Stephan Dietmar
Published: March 2020

The interaction of different charged polymers, namely anionic polycarboxylate superplasticizer (PCE) and neutral polyethylene glycol (PEG) with potassium ions, and their effect on the yield stress of highly concentrated glass bead suspension (GBS), were studied under different concentrations of potassium ions ([K+]). It was found that, compared to the neutral PEG, the negatively charged PCE can be adsorbed on glass beads (GB), and then decreases the yield stress of GBS. The increasing concentration of free polymer in the interstitial liquid phase with the increased polymer dosage leads to the higher yield stress of GBS, which may be caused by the higher depletion force. In addition, this effect is also related to the charge density of the polymer and the [K+] in the solution. Along with the increase in [K+], the yield stress of GBS increases significantly with the addition of PCE, but this cannot be observed with PEG, which indicates that potassium ions can interact with negatively charged PCE instead of the neutral PEG. At last, the interparticle forces between two single GB with adsorbed PCE in solutions containing [K+] and PCE were measured by colloidal probe atomic force microscopy to better understand the interaction of the charged polymer with counterions.
Cytotoxic Effects of Zoom® Whitening Product in Human Fibroblasts
Authors: Marto Carlos Miguel , Laranjo Mafalda , Paula Anabela , Coelho Ana Sofia , Abrantes Ana Margarida , Casalta-Lopes João , Gonçalves Ana Cristina , Sarmento-Ribeiro Ana Bela , Ferreira Manuel Marques , Cabrita António , Botelho Maria Filomena , Carrilho Eunice
Published: March 2020

Tooth whitening procedures are increasing; however, side effects can occur, such as damage to pulp cells, by the whitening products. This study aims to assess the cellular effects promoted by a whitening product, namely, the oxidative stress fostered by the active agent hydrogen peroxide, with and without photoactivation. Additionally, if cellular recovery occurred, we intended to determine the time point where cells recover from the tooth whitening induced damage. Human fibroblasts were exposed to hydrogen peroxide, Zoom®, Zoom® + irradiation, and irradiation alone. The following analysis was performed: metabolic activity evaluation by the MTT assay; cell viability, mitochondrial membrane potential, peroxides production, superoxide radical production, and reduced glutathione expression by flow cytometry. We determined the IC50 value for all groups, and a dose-dependent cytotoxic effect was verified. At the times analyzed, hydrogen peroxide groups showed no metabolic activity recovery while a cell recovery was observed after 24 h (Zoom®) and 48 h (Zoom® + irradiation). Cell death was seen in hydrogen peroxide and Zoom® + irradiation groups, mainly by apoptosis, and the irradiation had a cytotoxic effect per se. This in vitro study supports that whitening products with moderate hydrogen peroxide (HP) concentration have a temporary effect on cells, allowing a cellular recovery.
Stereolithographic Additive Manufacturing of High Precision Glass Ceramic Parts
Authors: Schönherr Julia Anna , Baumgartner Sonja , Hartmann Malte , Stampfl Jürgen
Published: March 2020

Lithography based additive manufacturing (AM) is one of the most established and widely used 3D-printing processes. It has enabled the processing of many different materials from thermoplast-like polymers to ceramics that have outstanding feature resolutions and surface quality, with comparable properties of traditional materials. This work focuses on the processing of glass ceramics, which have high optical demands, precision and mechanical properties specifically suitable for dental replacements, such as crowns. Lithography-based ceramic manufacturing (LCM) has been chosen as the optimal manufacturing process where a light source with a defined wavelength is used to cure and structure ceramic filled photosensitive resins. In the case of glass ceramic powders, plastic flow during thermal processing might reduce the precision, as well as the commonly observed sintering shrinkage associated with the utilized temperature program. To reduce this problem, particular sinter structures have been developed to optimize the precision of 3D-printed glass ceramic crowns. To evaluate the precision of the final part, testing using digitizing methods from optical to tactile systems were utilized with the best results were obtained from micro computed tomography (CT) scanning. These methods resulted in an optimized process allowing for possible production of high precision molar crowns with dimensional accuracy and high reproducibility.
A Study on the Thermal Properties of High-Strength Concrete Containing CBA Fine Aggregates
Authors: Yang In-Hwan , Park Jihun
Published: March 2020

The thermal conductivity of concrete is a key factor for efficient energy consumption in concrete buildings because thermal conductivity plays a significant role in heat transfer through concrete walls. This study investigated the effects of replacing fine aggregates with coal bottom ash (CBA) and the influence of curing age on the thermal properties of high-strength concrete with a compressive strength exceeding 60 MPa. The different CBA aggregate contents included 25%, 50%, 75%, and 100%, and different curing ages included 28 and 56 days. For concrete containing CBA fine aggregate, the thermal and mechanical properties, including the unit weight, thermal conductivity, compressive strength, and ultrasonic velocity, were measured. The experimental results reveal that the unit weight and thermal conductivity of the CBA concrete were highly dependent on the CBA content. The unit weight, thermal conductivity, and compressive strength of the concrete decreased as the CBA content increased. Relationships between the thermal conductivity and the unit weight, thermal conductivity and compressive strength of the CBA concrete were proposed in the form of exponential functions. The equations proposed in this study provided predictions that were in good agreement with the test results. In addition, the test results show that there was an approximately linear relationship between the thermal conductivity and ultrasonic velocity of the CBA concrete.
Study on Rheological Behavior of Micro/Nano-Silicon Carbide Particles in Ethanol by Selecting Efficient Dispersants
Authors: Luo Guoqiang , Zhang Zhuang , Hu Jianian , Zhang Jian , Sun Yi , Shen Qiang , Zhang Lianmeng
Published: March 2020

A colloidal stability study of a nonaqueous silicon carbide suspension is of great significance for preparing special silicon carbide ceramics by colloidal processing. In this paper, three different chemical dispersants, which are amphiphilic, acidophilic, and alkaliphilic, are selected to compare their ability to stabilize nonaqueous slurries of silicon carbide. The analysis of the flow index factor is first used to estimate the colloidal stability of the suspensions. The results show that the addition of only 5 wt.% polyvinylpyrrolidone (PVP) forms a silicon carbide slurry with a low viscosity value of 17 mPa⋅s at 25 s−1. In addition, Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS)measurements indicate that the PVP molecule is successfully adsorbed on the surface of silicon carbide. The different adsorption models are fitted, and the adsorption of PVP molecules on the surface of silicon carbide belongs to the Langmuir single-layer adsorption model. At the optimal PVP amount, the volume content of the suspension is as high as 22.27 vol.%, a Newtonian-like fluid still appears, and no agglomerate structure is formed in the system. After the volume content exceeds 22.27 vol.%, the flow index factor of the slurry begins to plummet, indicating that the slurry begins to transform from a Newtonian-like fluid to a shear-thinning fluid. The particles undergo inevitable agglomeration accompanied by the emergence of yield stress. Finally, a maximum solid loading of the system is predicted to be 46 vol.%, using the Krieger-Dougherty model.
Large Cutting Depth and Layered Milling of Titanium Alloy Thin-Walled Parts
Authors: Zha Jun , Liang Jianxin , Li Yipeng , Zhang Huijie , Chen Yaolong
Published: March 2020

Deformation of thin-walled titanium alloys can occur during the milling process due to the cutting force and chatter vibration, which can influence the precision of the finished parts. In this research, a new milling method without auxiliary support for machining of thin-walled parts was proposed. A large cutting depth and layered milling technology were used during rough machining, with a different machining allowance for each subsequent remaining layer. In the finishing stage, the surface of the previous layer needed to be dressed before processing the next layer. A TiAlSiN-coated, cemented carbide milling cutter was used to machine titanium alloy thin-walled parts, which are characterized by continuous multilayers of unequal thickness. The processing path was simulated using HyperMILL software, and the machining accuracy was detected by the 3D optical scanner. The measurement results indicated that the surface contour accuracy of the parts was ±0.21 mm, within a range of ±0.30 mm. The machining efficiency was increased by 40%, while guaranteeing machining accuracy.
The Impact of Bioceramic Scaffolds on Bone Regeneration in Preclinical In Vivo Studies: A Systematic Review
Authors: Brunello Giulia , Panda Sourav , Schiavon Lucia , Sivolella Stefano , Biasetto Lisa , Del Fabbro Massimo
Published: March 2020

Bioceramic scaffolds are appealing for alveolar bone regeneration, because they are emerging as promising alternatives to autogenous and heterogenous bone grafts. The aim of this systematic review is to answer to the focal question: in critical-sized bone defects in experimental animal models, does the use of a bioceramic scaffolds improve new bone formation, compared with leaving the empty defect without grafting materials or using autogenous bone or deproteinized bovine-derived bone substitutes? Electronic databases were searched using specific search terms. A hand search was also undertaken. Only randomized and controlled studies in the English language, published in peer-reviewed journals between 2013 and 2018, using critical-sized bone defect models in non-medically compromised animals, were considered. Risk of bias assessment was performed using the SYRCLE tool. A meta-analysis was planned to synthesize the evidence, if possible. Thirteen studies reporting on small animal models (six studies on rats and seven on rabbits) were included. The calvarial bone defect was the most common experimental site. The empty defect was used as the only control in all studies except one. In all studies the bioceramic materials demonstrated a trend for better outcomes compared to an empty control. Due to heterogeneity in protocols and outcomes among the included studies, no meta-analysis could be performed. Bioceramics can be considered promising grafting materials, though further evidence is needed.
Hot Deformation Characteristics and 3-D Processing Map of a High-Titanium Nb-Micro-alloyed Steel
Authors: Qian Pingping , Tang Zhenghua , Wang Li , Siyasiya Charles W.
Published: March 2020

Hot deformation behavior of a high-titanium Nb-micro-alloyed steel was investigated by conducting hot compression tests at the temperature of 900–1100 °C and the strain rate of 0.005–10 s−1. Using a sinh type constitutive equation, the apparent activation energy of the examined steel was 373.16 kJ/mol and the stress exponent was 6.059. The relations between Zener–Hollomon parameters versus peak stress (strain) or steady-state stress (strain) were successfully established via the Avrami equation. The dynamic recrystallization kinetics model of the examined steel was constructed and the validity was confirmed based on the experimental results. The 3-D atomic distribution maps illustrated that strain can significantly affect the values of power dissipation efficiency and the area of instability domains. The 3-D processing maps based on a dynamic material model at the strains of 0.2, 0.4, 0.6 and 0.8 were established. Based on traditional and 3-D processing maps and microstructural evaluation, the optimum parameter of for a high-titanium Nb-micro-alloyed steel was determined to be 1000–1050 °C/0.1–1 s−1.
Evaluation of the Thermal Stability and Surface Characteristics of Thermoplastic Polyurethane V-Belt
Authors: Krawiec Piotr , Różański Leszek , Czarnecka-Komorowska Dorota , Warguła Łukasz
Published: March 2020

This article proposes thermography as a non-contact diagnostic tool for assessing drive reliability. The application of this technique during the operation of the belt transmission with a heat-welded thermoplastic polyurethane V-belt was presented. The V-belt temperature changes depending on the braking torque load at different values of the rotational speed of the active pulley, which were adopted as diagnostic characteristics. In this paper, the surface morphology of the polyurethane (PU) belts was assessed on the basis of microscopic and hardness tests. A surface roughness tester was used to evaluate the surface wear. The surface morphology and topography of the materials was determined by scanning electron microscopy (SEM) and optical microscopy. It was found that the most favorable operating conditions occurred when the temperature values of active and passive connectors were similar and the temperature difference between them was small. The mechanical and structure results indicate that the wear of the PU belt was slight, which provided stability and operational reliability for V-belt transmission. The microscopic images lacked clear traces of cracks and scratches on the surface, which was confirmed by the SEM observations.
Study on the Durability of the T-Beam Based on Chloride Ion Erosion
Authors: Gu Lifeng , Yao Guowen , Yu Xuanrui , Li Qiaoyi
Published: March 2020

Based on analyzing the bearing capacity of existing T-beam bridges in service, the factors that affect the T-beams cracked by chloride ions mainly include the width and the depth of cracks. Combined with practical engineering examples, a single-piece T-beam model is established to explore the influence of factors such as crack width and crack depth on the T-beams affected by chloride ion erosion through numerical simulation in this paper. In addition, the attenuation models of bending capacity and shear capacity of the T-beam are obtained to analyze the possible failure modes of T-beams with cracks. All of which provides a reference for exploring the effect of crack width and depth on the durability of reinforced concrete members under chloride ion field.
Projected Subgradient Algorithms for Pseudomonotone Equilibrium Problems and Fixed Points of Pseudocontractive Operators
Authors: Yao Yonghong , Shahzad Naseer , Yao Jen-Chih
Published: March 2020

The projected subgradient algorithms can be considered as an improvement of the projected algorithms and the subgradient algorithms for the equilibrium problems of the class of monotone and Lipschitz continuous operators. In this paper, we present and analyze an iterative algorithm for finding a common element of the fixed point of pseudocontractive operators and the pseudomonotone equilibrium problem in Hilbert spaces. The suggested iterative algorithm is based on the projected method and subgradient method with a linearsearch technique. We show the strong convergence result for the iterative sequence generated by this algorithm. Some applications are also included. Our result improves and extends some existing results in the literature.