bluuebunny/crossref_metadata_2025 huggingface dataset:
Figure S8 from The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia
Authors: Su Yongwei , Carter Jenna L. , Li Xinyu , Fukuda Yu , Gray Ashley , Lynch John , Edwards Holly , Ma Jun , Schreiner Patrick , Polin Lisa , Kushner Juiwanna , Dzinic Sijana H. , Buck Steven A. , Pruett-Miller Shondra M. , Hege-Hurrish Katie , Robinson Camenzind , Qiao Xinan , Liu Shuang , Wu Shuangshuang , Wang Guan , Li Jing , Allen Joshua E. , Prabhu Varun V. , Schimmer Aaron D. , Joshi Dhananjay , Kalhor-Monfared Shiva , Watson Iain D. G. , Marcellus Richard , Isaac Methvin B. , Al-awar Rima , Taub Jeffrey W. , Lin Hai , Schuetz John D. , Ge Yubin
Published: April 2024

Supplementary Figure S8
Supplementary Fig.S14 from PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
Authors: Yamamoto Takehiro , Hayashida Tetsu , Masugi Yohei , Oshikawa Kiyotaka , Hayakawa Noriyo , Itoh Mai , Nishime Chiyoko , Suzuki Masami , Nagayama Aiko , Kawai Yuko , Hishiki Takako , Matsuura Tomomi , Naito Yoshiko , Kubo Akiko , Yamamoto Arisa , Yoshioka Yujiro , Kurahori Tomokazu , Nagasaka Misa , Takizawa Minako , Takano Naoharu , Kawakami Koji , Sakamoto Michiie , Wakui Masatoshi , Yamamoto Takushi , Kitagawa Yuko , Kabe Yasuaki , Horisawa Kenichi , Suzuki Atsushi , Matsumoto Masaki , Suematsu Makoto
Published: April 2024

Fig.S14
Figure S4 from The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia
Authors: Su Yongwei , Carter Jenna L. , Li Xinyu , Fukuda Yu , Gray Ashley , Lynch John , Edwards Holly , Ma Jun , Schreiner Patrick , Polin Lisa , Kushner Juiwanna , Dzinic Sijana H. , Buck Steven A. , Pruett-Miller Shondra M. , Hege-Hurrish Katie , Robinson Camenzind , Qiao Xinan , Liu Shuang , Wu Shuangshuang , Wang Guan , Li Jing , Allen Joshua E. , Prabhu Varun V. , Schimmer Aaron D. , Joshi Dhananjay , Kalhor-Monfared Shiva , Watson Iain D. G. , Marcellus Richard , Isaac Methvin B. , Al-awar Rima , Taub Jeffrey W. , Lin Hai , Schuetz John D. , Ge Yubin
Published: April 2024

Supplementary Figure S4
Supplementary Fig.S10 from PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
Authors: Yamamoto Takehiro , Hayashida Tetsu , Masugi Yohei , Oshikawa Kiyotaka , Hayakawa Noriyo , Itoh Mai , Nishime Chiyoko , Suzuki Masami , Nagayama Aiko , Kawai Yuko , Hishiki Takako , Matsuura Tomomi , Naito Yoshiko , Kubo Akiko , Yamamoto Arisa , Yoshioka Yujiro , Kurahori Tomokazu , Nagasaka Misa , Takizawa Minako , Takano Naoharu , Kawakami Koji , Sakamoto Michiie , Wakui Masatoshi , Yamamoto Takushi , Kitagawa Yuko , Kabe Yasuaki , Horisawa Kenichi , Suzuki Atsushi , Matsumoto Masaki , Suematsu Makoto
Published: April 2024

Fig.S10
Table S2A from Osteosarcoma Cells Secrete CXCL14 That Activates Integrin α11β1 on Fibroblasts to Form a Lung Metastatic Niche
Authors: Xu Yanyang , Deng Chuangzhong , Chen Hongmin , Song YiJiang , Xu Huaiyuan , Song Guohui , Wang Xinliang , Luo Tianqi , Chen Weiqing , Ma Jiahui , Zeng Anyu , Huang Shujing , Chen Zhihao , Fu Jianchang , Gong Ming , Tai Yi , Huang Anfei , Feng Huixiong , Hu Jinxin , Zhu Xiaojun , Tang Qinglian , Lu Jinchang , Wang Jin
Published: April 2024

Genes differently expressed in each cluster.
Data from Subclonal Cancer Driver Mutations Are Prevalent in the Unresected Peritumoral Edema of Adult Diffuse Gliomas
Authors: Underhill Hunter R. , Karsy Michael , Davidson Christian J. , Hellwig Sabine , Stevenson Samuel , Goold Eric A. , Vincenti Sydney , Sellers Drew L. , Dean Charlie , Harrison Brion E. , Bronner Mary P. , Colman Howard , Jensen Randy L.
Published: April 2024

Abstract
Adult diffuse gliomas commonly recur regardless of therapy. As recurrence typically arises from the peritumoral edema adjacent to the resected bulk tumor, the profiling of somatic mutations from infiltrative malignant cells within this critical, unresected region could provide important insights into residual disease. A key obstacle has been the inability to distinguish between next-generation sequencing (NGS) noise and the true but weak signal from tumor cells hidden among the noncancerous brain tissue of the peritumoral edema. Here, we developed and validated True2 sequencing to reduce NGS-associated errors to <1 false positive/100 kb panel positions while detecting 97.6% of somatic mutations with an allele frequency ≥0.1%. True2 was then used to study the tumor and peritumoral edema of 22 adult diffuse gliomas including glioblastoma, astrocytoma, oligodendroglioma, and NF1-related low-grade neuroglioma. The tumor and peritumoral edema displayed a similar mutation burden, indicating that surgery debulks these cancers physically but not molecularly. Moreover, variants in the peritumoral edema included unique cancer driver mutations absent in the bulk tumor. Finally, analysis of multiple samples from each patient revealed multiple subclones with unique mutations in the same gene in 17 of 22 patients, supporting the occurrence of convergent evolution in response to patient-specific selective pressures in the tumor microenvironment that may form the molecular foundation of recurrent disease. Collectively, True2 enables the detection of ultralow frequency mutations during molecular analyses of adult diffuse gliomas, which is necessary to understand cancer evolution, recurrence, and individual response to therapy.
Significance:
True2 is a next-generation sequencing workflow that facilitates unbiased discovery of somatic mutations across the full range of variant allele frequencies, which could help identify residual disease vulnerabilities for targeted adjuvant therapies.
Data from Human Tumor–Associated Macrophages and Neutrophils Regulate Antitumor Antibody Efficacy through Lethal and Sublethal Trogocytosis
Authors: Singhal Sunil , Rao Abhishek S. , Stadanlick Jason , Bruns Kyle , Sullivan Neil T. , Bermudez Andres , Honig-Frand Adam , Krouse Ryan , Arambepola Sachinthani , Guo Emily , Moon Edmund K. , Georgiou George , Valerius Thomas , Albelda Steven M. , Eruslanov Evgeniy B.
Published: April 2024

Abstract
The clinical benefits of tumor-targeting antibodies (tAb) are modest in solid human tumors. The efficacy of many tAbs is dependent on Fc receptor (FcR)–expressing leukocytes that bind Fc fragments of tAb. Tumor-associated macrophages (TAM) and neutrophils (TAN) represent the majority of FcR+ effectors in solid tumors. A better understanding of the mechanisms by which TAMs and TANs regulate tAb response could help improve the efficacy of cancer treatments. Here, we found that myeloid effectors interacting with tAb-opsonized lung cancer cells used antibody-dependent trogocytosis (ADT) but not antibody-dependent phagocytosis. During this process, myeloid cells “nibbled off” tumor cell fragments containing tAb/targeted antigen (tAg) complexes. ADT was only tumoricidal when the tumor cells expressed high levels of tAg and the effectors were present at high effector-to-tumor ratios. If either of these conditions were not met, which is typical for solid tumors, ADT was sublethal. Sublethal ADT, mainly mediated by CD32hiCD64hi TAM, led to two outcomes: (i) removal of surface tAg/tAb complexes from the tumor that facilitated tumor cell escape from the tumoricidal effects of tAb; and (ii) acquisition of bystander tAgs by TAM with subsequent cross-presentation and stimulation of tumor-specific T-cell responses. CD89hiCD32loCD64lo peripheral blood neutrophils (PBN) and TAN stimulated tumor cell growth in the presence of the IgG1 anti-EGFR Ab cetuximab; however, IgA anti-EGFR Abs triggered the tumoricidal activity of PBN and negated the stimulatory effect of TAN. Overall, this study provides insights into the mechanisms by which myeloid effectors mediate tumor cell killing or resistance during tAb therapy.
Significance:
The elucidation of the conditions and mechanisms by which human FcR+ myeloid effectors mediate cancer cell resistance and killing during antibody treatment could help develop improved strategies for treating solid tumors.
Exploring Ferroptosis-Inducing Therapies for Cancer Treatment: Challenges and Opportunities
Authors: Lei Guang , Gan Boyi
Published: April 2024

Conventional cancer therapies typically aim to eliminate tumor cells by inducing cell death. The emergence of resistance to these standard treatments has spurred a shift in focus toward exploring alternative cell death pathways beyond apoptosis. Ferroptosis—an iron-dependent regulated cell death triggered by lipid peroxide accumulation—has gained prominence in cancer research in recent years. Ferroptosis-inducing therapies hold promise for overcoming resistance encountered with conventional treatments. However, challenges, including the lack of distinctive ferroptosis markers and the intricate role of ferroptosis within the tumor microenvironment, currently hinder the clinical translation of these therapies. This perspective article critically outlines these hurdles and highlights unexplored opportunities in ferroptosis research, aiming to refine its therapeutic utilization in combating cancer.
The Rigidity Connection: Matrix Stiffness and Its Impact on Cancer Progression
Authors: Yui Anna , Oudin Madeleine J.
Published: April 2024

The extracellular matrix (ECM) has always been studied in the context of the structural support it provides tissues. However, more recently, it has become clear that ECM proteins do more to regulate biological processes relevant to cancer progression: from activating complex signaling pathways to presenting soluble growth factors. In 2009, Ulrich and colleagues provided evidence that the physical properties of the ECM could also contribute to glioblastoma tumor cell proliferation and invasion using tunable hydrogels, emphasizing a role for tumor rigidity in central nervous system cancer progression. Here, we will discuss the results of this landmark article, as well as highlight other work that has shown the importance of tissue stiffness in glioblastoma and other tumor types in the tumor microenvironment. Finally, we will discuss how this research has led to the development of novel treatments for cancer that target tumor rigidity.

See related article by Ulrich and colleagues, Cancer Res 2009;69:4167–74
Personalized Cancer Vaccines Directed against Tumor Mutations: Building Evidence from Mice to Humans
Authors: Fritsch Edward F. , Ott Patrick A.
Published: April 2024

Personalized vaccines directed to tumor mutations have recently gained significant momentum. On the basis of the concept of stimulating T-cell responses against neoantigens encoded by a tumor's host of personal mutations, these vaccines utilize genome or exome sequencing, mutation calling, and epitope prediction followed by manufacturing of a customized vaccine for each patient. In their 2012 Cancer Research publication, Castle and colleagues provided evidence that vaccinating with long peptide vaccines encompassing neoantigens can generate robust immune responses and induce antitumor activity in a mouse B16F10 melanoma. This approach, harnessing the exquisite specificity of mutations to the tumor and thus providing an effective target for cancer vaccines, was subsequently shown to be safe and immunogenic in a series of small first in man trials in patients with melanoma. The field has accelerated and expanded substantially over the last 5 years, propelled by increasing evidence for vaccine-mediated clinical efficacy, leading to ongoing registrational trials using personalized RNA neoantigen vaccines in patients with melanoma and several other malignancies.

See related article by Castle and colleagues, Cancer Res 2012;72:1081–91
Cancer Builds a Noxious Partnership with Psychologic Stress
Authors: Magnon Claire
Published: April 2024

I was recently surprised to hear a medical doctor on a TV show refute the role of stress in cancer, assuming that “the whole population would have cancer if this was the case.” This statement illustrates a long and winding road since Hippocrates suggested the potential relationship between cancer and psychologic disturbances. The 20th and 21st centuries have finally witnessed the evidence of how physical or psychosocial stress situations contribute to the development and progression of cancer, and it is now assumed that psychologic stress does affect multiple aspects of cancer such as angiogenesis, immunologic escape, invasion, and metastasis. The 2010 publication by Sloan and colleagues in Cancer Research achieved a mechanistic step toward the understanding of how physical distress enhances metastasis through perturbation of the tumor immune system and paves the way for future cancer research in psychoneuroimmunology. This Landmark commentary places this publication in the historical context of science, discusses major advances in the field, and asks questions to be answered while drawing perspectives on the key role of the peripheral and central nervous systems in cancer.

See related article by Sloan and colleagues, Cancer Res 2010;70:7042–52
Supplemental Table 4 from Cytogenetic and Molecular Associations with Outcomes in Higher-Risk Myelodysplastic Syndromes Treated with Hypomethylating Agents plus Venetoclax
Authors: Bazinet Alexandre , Desikan Sai Prasad , Li Ziyi , Rodriguez-Sevilla Juan Jose , Venugopal Sangeetha , Urrutia Samuel , Montalban-Bravo Guillermo , Sasaki Koji , Chien Kelly S. , Hammond Danielle , Kanagal-Shamanna Rashmi , Ganan-Gomez Irene , Kadia Tapan M. , Borthakur Gautam , DiNardo Courtney D. , Daver Naval G. , Jabbour Elias J. , Ravandi Farhad , Kantarjian Hagop , Garcia-Manero Guillermo
Published: April 2024

Supplemental Table 4: Baseline characteristics in HMA-naïve patients with HR-MDS treated with HMA plus venetoclax versus a contemporary HMA monotherapy cohort.
Supplemental Table 3 from Cytogenetic and Molecular Associations with Outcomes in Higher-Risk Myelodysplastic Syndromes Treated with Hypomethylating Agents plus Venetoclax
Authors: Bazinet Alexandre , Desikan Sai Prasad , Li Ziyi , Rodriguez-Sevilla Juan Jose , Venugopal Sangeetha , Urrutia Samuel , Montalban-Bravo Guillermo , Sasaki Koji , Chien Kelly S. , Hammond Danielle , Kanagal-Shamanna Rashmi , Ganan-Gomez Irene , Kadia Tapan M. , Borthakur Gautam , DiNardo Courtney D. , Daver Naval G. , Jabbour Elias J. , Ravandi Farhad , Kantarjian Hagop , Garcia-Manero Guillermo
Published: April 2024

Supplemental Table 3: Overall response rate and complete remission rate by venetoclax dose and schedule.
Supplementary Figure S5 from Combined Vorinostat and Chloroquine Inhibit Sodium–Iodide Symporter Endocytosis and Enhance Radionuclide Uptake In Vivo
Authors: Read Martin L. , Brookes Katie , Zha Ling , Manivannan Selvambigai , Kim Jana , Kocbiyik Merve , Fletcher Alice , Gorvin Caroline M. , Firth George , Fruhwirth Gilbert O. , Nicola Juan P. , Jhiang Sissy , Ringel Matthew D. , Campbell Moray J. , Sunassee Kavitha , Blower Philip J. , Boelaert Kristien , Nieto Hannah R. , Smith Vicki E. , McCabe Christopher J.
Published: April 2024

Supplementary Figure S5
Supplementary Figure S6 from Sensitive MRD Detection from Lymphatic Fluid after Surgery in HPV-Associated Oropharyngeal Cancer
Authors: Earland Noah , Semenkovich Nicholas P. , Ramirez Ricardo J. , Gerndt Sophie P. , Harris Peter K. , Gu Zhuosheng , Hearn Andrew I. , Inkman Matthew , Szymanski Jeffrey J. , Whitfield Damion , Wahle Benjamin M. , Xu Zhongping , Chen Kevin , Alahi Irfan , Ni Gabris , Chen Andrew , Winckler Wendy , Zhang Jin , Chaudhuri Aadel A. , Zevallos Jose P.
Published: April 2024

HPV (+) OPSCC recurrences stratified by postoperative lymph cf-HPV detection, plasma cf-HPV detection, or high-risk pathology.
Supplementary Figure S4 from Sensitive MRD Detection from Lymphatic Fluid after Surgery in HPV-Associated Oropharyngeal Cancer
Authors: Earland Noah , Semenkovich Nicholas P. , Ramirez Ricardo J. , Gerndt Sophie P. , Harris Peter K. , Gu Zhuosheng , Hearn Andrew I. , Inkman Matthew , Szymanski Jeffrey J. , Whitfield Damion , Wahle Benjamin M. , Xu Zhongping , Chen Kevin , Alahi Irfan , Ni Gabris , Chen Andrew , Winckler Wendy , Zhang Jin , Chaudhuri Aadel A. , Zevallos Jose P.
Published: April 2024

Cell-free HPV is enriched in the lymph relative to patient-matched plasma and does not correlate with primary tumor features or smoking history
Supplementary Figure S2 from Sensitive MRD Detection from Lymphatic Fluid after Surgery in HPV-Associated Oropharyngeal Cancer
Authors: Earland Noah , Semenkovich Nicholas P. , Ramirez Ricardo J. , Gerndt Sophie P. , Harris Peter K. , Gu Zhuosheng , Hearn Andrew I. , Inkman Matthew , Szymanski Jeffrey J. , Whitfield Damion , Wahle Benjamin M. , Xu Zhongping , Chen Kevin , Alahi Irfan , Ni Gabris , Chen Andrew , Winckler Wendy , Zhang Jin , Chaudhuri Aadel A. , Zevallos Jose P.
Published: April 2024

Blood contamination does not significantly impact lymph cf-HPV measurement.
Supplementary Table S5 from Combining Genomic Biomarkers to Guide Immunotherapy in Non–Small Cell Lung Cancer
Authors: van de Haar Joris , Mankor Joanne M. , Hummelink Karlijn , Monkhorst Kim , Smit Egbert F. , Wessels Lodewyk F.A. , Cuppen Edwin , Aerts Joachim G.J.V. , Voest Emile E.
Published: April 2024

Baseline characteristics of patients in the validation cohort, stratified by the TMB and STK11/KEAP1/EGFR alteration status.
Supplementary Figure S1 from Mechanistic Modeling of Intrathecal Chemotherapy Pharmacokinetics in the Human Central Nervous System
Authors: Li Jing , Wu Andrew , Kim Seongho
Published: April 2024

Supplementary Figure S1. Model-predicted unbound drug – concentration time profiles in the ventricular CSF (Cvcsf), cranial subarachnoid CSF (Cccsf), spinal subarachnoid (Cscsf), adjacent brain tissue (Cbm1), and deep brain parenchyma (Cbm2), following intraventricular injection.
Supplementary Table S3 from Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non–Small Cell Lung Cancer
Authors: Guan Shaoxing , Chen Xi , Wei Yuru , Wang Fei , Xie Wen , Chen Youhao , Liang Heng , Zhu Xia , Yang Yunpeng , Fang Wenfeng , Huang Yan , Zhao Hongyun , Zhang Xiaoxu , Liu Shu , Zhuang Wei , Huang Min , Wang Xueding , Zhang Li
Published: April 2024

Table S3. Candidate genes associated with survival in patients with LUAD.
Supplementary Figure S6 from Dual-Hit Strategy for Therapeutic Targeting of Pancreatic Cancer in Patient-Derived Xenograft Tumors
Authors: Roy Chaudhuri Tista , Lin Qingxiang , Stachowiak Ewa K. , Rosario Spencer R. , Spernyak Joseph A. , Ma Wen Wee , Stachowiak Michal K. , Greene Michelle K. , Quinn Gerard P. , McDade Simon S. , Clynes Martin , Scott Christopher J. , Straubinger Robert M.
Published: April 2024

Supplementary Figure S6. Analysis of transcription factor and master regulator enrichment of differentially expressed genes predict kinase-driven transcriptional changes in SHHi-treated tumors
Supplementary Figure 2 from Phase II Study of Eribulin plus Pembrolizumab in Metastatic Soft-tissue Sarcomas: Clinical Outcomes and Biological Correlates
Authors: Haddox Candace L. , Nathenson Michael J. , Mazzola Emanuele , Lin Jia-Ren , Baginska Joanna , Nau Allison , Weirather Jason L. , Choy Edwin , Marino-Enriquez Adrian , Morgan Jeffrey A. , Cote Gregory M. , Merriam Priscilla , Wagner Andrew J. , Sorger Peter K. , Santagata Sandro , George Suzanne
Published: April 2024

Supplementary Figure 2. Serum cytokine levels.
Data from Combining Genomic Biomarkers to Guide Immunotherapy in Non–Small Cell Lung Cancer
Authors: van de Haar Joris , Mankor Joanne M. , Hummelink Karlijn , Monkhorst Kim , Smit Egbert F. , Wessels Lodewyk F.A. , Cuppen Edwin , Aerts Joachim G.J.V. , Voest Emile E.
Published: April 2024

AbstractPurpose:
The clinical value of STK11, KEAP1, and EGFR alterations for guiding immune checkpoint blockade (ICB) therapy in non–small cell lung cancer (NSCLC) remains controversial, as some patients with these proposed resistance biomarkers show durable ICB responses. More specific combinatorial biomarker approaches are urgently needed for this disease.
Experimental Design:
To develop a combinatorial biomarker strategy with increased specificity for ICB unresponsiveness in NSCLC, we performed a comprehensive analysis of 254 patients with NSCLC treated with programmed death-ligand 1 (PD-L1) blockade monotherapy, including a discovery cohort of 75 patients subjected to whole-genome sequencing (WGS), and an independent validation cohort of 169 patients subjected to tumor-normal large panel sequencing. The specificity of STK11/KEAP1/EGFR alterations for ICB unresponsiveness was assessed in the contexts of a low (<10 muts/Mb) or high (≥10 muts/Mb) tumor mutational burden (TMB).
Results:
In low TMB cases, STK11/KEAP1/EGFR alterations were highly specific biomarkers for ICB resistance, with 0/15 (0.0%) and 1/34 (2.9%) biomarker-positive patients showing treatment benefit in the discovery and validation cohorts, respectively. This contrasted with high TMB cases, where 11/13 (85%) and 15/34 (44%) patients with at least one STK11/KEAP1/EGFR alteration showed durable treatment benefit in the discovery and validation cohorts, respectively. These findings were supported by analyses of progression-free survival and overall survival.
Conclusions:
The unexpected ICB responses in patients carrying resistance biomarkers in STK11, KEAP1, and EGFR were almost exclusively observed in patients with a high TMB. Considering these alterations in context of the TMB offered a highly specific combinatorial biomarker strategy for limiting overtreatment in NSCLC.
Living in Syn: T Cell Antigen Identification Based on Synapse Sequencing
Authors: Makani Venkata Krishna Kanth , Joglekar Alok V.
Published: April 2024

The pivotal role of T cell responses has been well studied in both protective and destructive scenarios. T cells recognize peptide epitopes presented on Human Leukocyte Antigens (HLA) through their surface T cell receptors (TCR). Advances in single-cell RNA sequencing have identified millions of TCRs, but only a minuscule fraction of them have known epitopes. Recently, cell-based T cell antigen discovery platforms have emerged onto the landscape. Here, Jin and colleagues, report a novel antigen discovery platform called Tsyn-seq that relies on sequencing TCR-peptide-HLA–induced synapses for genome-wide epitope screening.

See related article by Jin et al., p. 530 (3).
Imunização contra covid-19 e mortalidade em pacientes hospitalizados: coorte retrospectiva
Authors: Fernandez Michelle , Figueiredo Alexandre Medeiros de , Massuda Adriano , Medeiros Neto Agostinho Hermes de , Carvalho Marcus
Published: April 2024

OBJETIVO: Avaliar a efetividade das vacinas desenvolvidas contra a covid-19 na redução da mortalidade em pessoas internadas com síndrome respiratória aguda grave (SRAG) causada pelo SARS-CoV-2. MÉTODOS: Trata-se de uma coorte retrospectiva que avaliou fatores de riscos e a efetividade do esquema vacinal com duas doses na redução da mortalidade de pessoas internadas por covid-19 no estado da Paraíba entre fevereiro e novembro de 2021. As variáveis explicativas foram situação vacinal, presença de comorbidades, características socioeconômicas e demográficas. Foram realizadas análises descritivas e regressão logística bivariada e multivariável. RESULTADOS: A maior parte das internações e óbitos ocorreram até maio de 2021. O percentual de pacientes com esquema vacinal completo foi similar entre pacientes internados em hospitais públicos e privados e superior em residentes de municípios com menor desenvolvimento. A análise multivariável demonstrou que mulheres (OR = 0,896; IC95% 0,830–0,967) e pessoas internadas em hospitais privados (OR = 0,756; IC95% 0,679–0,842) apresentaram menor chance de morte. A presença de alguma comorbidade (OR = 1,627; IC95% 1,500–1,765) e idade ≥ 80 anos (OR = 7,426; IC95% 6,309–8,741) foram fatores de risco de óbito. Pacientes com esquema vacinal completo no momento da internação apresentaram uma chance 41,7% menor de morte (OR = 0,583; IC95% 0,501–0,679) por covid-19 na análise ajustada, quando comparados com pacientes não vacinados. CONCLUSÕES: O estudo revela que a imunização foi efetiva na redução da chance de óbito por covid-19. Os resultados sugerem que uma maior cobertura vacinal no primeiro semestre de 2021 evitaria milhares de mortes no país.
CD151 Maintains Endolysosomal Protein Quality to Inhibit Vascular Inflammation
Authors: Chen Junxiong , Ding Yingjun , Jiang Chao , Qu Rongmei , Wren Jonathan D. , Georgescu Constantin , Wang Xuejun , Reuter Darlene N. , Liu Beibei , Giles Cory B. , Mayr Christoph H. , Schiller Herbert B. , Dai Jingxing , Stipp Christopher S. , Subramaniyan Bharathiraja , Wang Jie , Zuo Houjuan , Huang Chao , Fung Kar-Ming , Rice Heather C. , Sonnenberg Arnoud , Wu David , Walters Matthew S. , Zhao You-Yang , Kanie Tomoharu , Hays Franklin A. , Papin James F. , Wang Dao Wen , Zhang Xin A.
Published: April 2024

BACKGROUND:

Tetraspanin CD151 is highly expressed in endothelia and reinforces cell adhesion, but its role in vascular inflammation remains largely unknown.

METHODS:

In vitro molecular and cellular biological analyses on genetically modified endothelial cells, in vivo vascular biological analyses on genetically engineered mouse models, and in silico systems biology and bioinformatics analyses on CD151-related events.

RESULTS:

Endothelial ablation of
Cd151
leads to pulmonary and cardiac inflammation, severe sepsis, and perilous COVID-19, and endothelial CD151 becomes downregulated in inflammation. Mechanistically, CD151 restrains endothelial release of proinflammatory molecules for less leukocyte infiltration. At the subcellular level, CD151 determines the integrity of multivesicular bodies/lysosomes and confines the production of exosomes that carry cytokines such as ANGPT2 (angiopoietin-2) and proteases such as cathepsin-D. At the molecular level, CD151 docks VCP (valosin-containing protein)/p97, which controls protein quality via mediating deubiquitination for proteolytic degradation, onto endolysosomes to facilitate VCP/p97 function. At the endolysosome membrane, CD151 links VCP/p97 to (1) IFITM3 (interferon-induced transmembrane protein 3), which regulates multivesicular body functions, to restrain IFITM3-mediated exosomal sorting, and (2) V-ATPase, which dictates endolysosome pH, to support functional assembly of V-ATPase.

CONCLUSIONS:

Distinct from its canonical function in strengthening cell adhesion at cell surface, CD151 maintains endolysosome function by sustaining VCP/p97-mediated protein unfolding and turnover. By supporting protein quality control and protein degradation, CD151 prevents proteins from (1) buildup in endolysosomes and (2) discharge through exosomes, to limit vascular inflammation. Also, our study conceptualizes that balance between degradation and discharge of proteins in endothelial cells determines vascular information. Thus, the IFITM3/V-ATPase-tetraspanin-VCP/p97 complexes on endolysosome, as a protein quality control and inflammation-inhibitory machinery, could be beneficial for therapeutic intervention against vascular inflammation.
Exploring the Inclusion of Person-Centered Care Domains in Stroke Transitions of Care Interventions: A Scientific Statement From the American Heart Association
Authors: Nelson Michelle L.A. , MacEachern Evan , Prvu Bettger Janet , Camicia Michelle , García James J. , Kapral Moira K. , Mathiesen Claranne , Cameron Jill I. ,   on behalf of the American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; and Council on Quality of Care and Outcomes Research
Published: April 2024

BACKGROUND:

Health care teams along the stroke recovery continuum have a responsibility to support care transitions and return to the community. Ideally, individualized care will consider patient and family preferences, best available evidence, and health care professional input. Person-centered care can improve patient-practitioner interactions through shared decision-making in which health professionals and institutions are sensitive to those for whom they provide care. However, it is unclear how the concepts of person-centered care have been described in reports of stroke transitional care interventions.

METHODS:

A secondary analysis of a systematic review and meta-analysis was undertaken. We retrieved all included articles (n=17) and evaluated the extent to which each intervention explicitly addressed 7 domains of person-centered care: alignment of care with patients’ values, preferences, and needs; coordination of care; information and education; physical comfort; emotional support; family and friend involvement; and smooth transition and continuity of care.

RESULTS:

Most of the articles included some aspects of person-centeredness; we found that certain domains were not addressed in the descriptions of transitional care interventions, and no articles mentioned all 7 domains of person-centered care. We identified 3 implications for practice and research: (1) delineating person-centered care components when reporting interventions, (2) elucidating social and cultural factors relevant to the study sample and intervention, and (3) clearly describing the role of family and nonmedical support in the intervention.

CONCLUSIONS:

There is still room for greater consistency in the reporting of person-centeredness in stroke transitions of care interventions, despite a long-standing definition and conceptualization of person-centered care in academic and clinically focused literature.
The Relevance of Unaccusativity to Possessive Datives
Authors: Plotnik Ziv , Meltzer-Asscher Aya , Siloni Tal
Published: April 2024

The possessive dative construction has been widely adopted as an unaccusativity diagnostic (Borer and Grodzinsky 1986). Gafter (2014) casts doubt on the relevance of unaccusativity to the acceptability of the construction. We conducted a series of acceptability judgment experiments to investigate the validity of the possessive dative construction as an unaccusativity diagnostic, controlling for possible confounds such as animacy, definiteness, plausibility, lexical choice, type of possession, and context salience. The experiments revealed that possessive datives are significantly more acceptable with unaccusative verbs than with unergatives, including reflexive and emission verbs. We conclude that unaccusatives, but not unergatives, are grammatical in the construction, and we defend a structural account of the data.
Large Language Models and the Argument from the Poverty of the Stimulus
Authors: Lan Nur , Chemla Emmanuel , Katzir Roni
Published: April 2024

According to much of theoretical linguistics, a fair amount of our linguistic knowledge is innate. One of the best-known (and most contested) kinds of evidence for a large innate endowment is the argument from the poverty of the stimulus (APS). An APS obtains when human learners systematically make inductive leaps that are not warranted by the linguistic evidence. A weakness of the APS has been that it is very hard to assess what is warranted by the linguistic evidence. Current artificial neural networks appear to offer a handle on this challenge, and a growing literature has started to explore the potential implications of such models to questions of innateness. We focus on Wilcox, Futrell, and Levy’s (2024) use of several different networks to examine the available evidence as it pertains to wh-movement, including island constraints. WFL conclude that the (presumably linguistically neutral) networks acquire an adequate knowledge of wh-movement, thus undermining an APS in this domain. We examine the evidence further, looking in particular at parasitic gaps and across-the-board movement, and argue that current networks do not succeed in acquiring or even adequately approximating wh-movement from training corpora roughly the size of the linguistic input that children receive. We also show that the performance of one of the models improves considerably when the training data are artificially enriched with instances of parasitic gaps and across-the-board movement. This finding suggests, albeit tentatively, that the networks’ failure when trained on natural, unenriched corpora is due to the insufficient richness of the linguistic input, thus supporting the APS.
Challenges, Preoperative Assessment, and Surgical Strategies for the Left-Sided Gallbladder
Authors: Starich Olivia A. , Chanes Nicolas M. , Bakhtiyar Syed Shahyan , Aryanpour Zain , Brooke Magdalene A.
Published: April 2024

Left-sided gallbladder positioning, or sinistroposition, is a rare anatomical variation that poses challenges during surgical intervention due to associated vascular and biliary anomalies. While existing literature suggests an incidence of approximately 0.04-1.1%, it remains an underreported phenomenon that falls well outside the realm of “expected” anatomical variation and are rarely identified on preoperative imaging. Here, we present a case of acute cholecystitis in a patient with unexpected left-sided gallbladder, highlighting the associated challenges and outlining both preoperative and intraoperative strategies for managing this rare but consequential anatomical variant. In this case, a 49-year-old woman with a prior history of bilateral ovarian cysts presented with clinical, laboratory, and imaging findings consistent with acute cholecystitis. She underwent laparoscopic cholecystectomy and was found to have a severely inflamed left-sided gallbladder that was obscured by omentum. Her gallbladder was found in the midline immediately beneath the falciform ligament, with most of the gallbladder body and fundus attached to liver segment III, situated to the left of the midline. An additional left-sided mid-abdominal port was required to enhance retraction, and an intraoperative cholangiogram (IOC) was performed given the elevated risk of structural injury. This case underscores the heightened intraoperative risk associated with deviations in vascular and biliary anatomy and provides recommendations for intraoperative adaptations to mitigate these risks.
Hepatic Ablation Technology: Assessment of Conflicts of Interest in Recent Literature
Authors: Kooragayala Keshav , Moccia Matthew C. , Spitz Frank , Lenart Austin , Gandhi Tanay-Veer , Koneru Manisha , Hong Young
Published: April 2024

Introduction

Collaboration between the health care industry and surgeons is critical in modern medicine. Conflict of interest (COI) has the risk of introducing bias into research studies. We investigated the accuracy of self-disclosed COI for studies that researched the use of microwave ablation for liver metastasis.

Methods

A literature search identified studies that investigated the use of microwave ablation for liver cancer between 2016 and 2022. We utilized the Open Payments Database to query individual authors’ financial contributions from the industry. The accuracy of the disclosure statement and financial contribution for each study and author was calculated. We compared the amount of financial contribution authors received based on the accuracy of their COI statement.

Results

Twenty-five studies of interest were identified. The mean number of authors was 8.24. A disclosure statement was present in 52% of studies. Of those, 28% had an incongruent disclosure statement. 9/25 (36%) of studies had a conflict of interest based on financial payments provided by industry. Overall, authors received an average of $440,483.41 (SD $1,889,375.34). We did not find a difference in the financial contribution’s value based on the disclosure statement’s accuracy ( P = .55).

Conclusions

Over a quarter of studies in our review of microwave ablation literature had discrepancies in the reporting of conflicts of interest, highlighting the need for improved reporting of potential conflicts of interest to protect the integrity of clinical research. Compared to other fields of surgery, we found a lower rate of undisclosed COI, suggesting that the scope of cancer-directed surgery may be more resistant to industry influence.
Prediction of Post-Gastrectomy Pancreatic Complications: A Preoperative Imaging Study Based on Computed Tomography
Authors: Ohi Masaki , Toiyama Yuji , Yasuda Hiromi , Ichikawa Takashi , Uratani Ryo , Kitajima Takahito , Shimura Tadanobu , Imaoka Hiroki , Kawamura Mikio , Morimoto Yuki , Okugawa Yoshinaga , Okita Yoshiki , Yoshiyama Shigeyuki
Published: April 2024

Background

Postoperative pancreas-related complications (PPRCs) are common after laparoscopic gastrectomy (LG) in patients with gastric cancer. We estimated the anatomical location of the pancreas on a computed tomography (CT) image and investigated its impact on the incidence of PPRCs after LG.

Methods

We retrospectively reviewed the preoperative CT images of 203 patients who underwent LG for gastric cancer between January 2010 and December 2017. From these images, we measured the gap between the upper edge of the pancreatic body and the root of the common hepatic artery. We evaluated the potential relationship between PPRCs and the gap between pancreas and common hepatic artery (GPC) status using an analysis based on the median cutoff value and assessed the impact of GPC status on PPRC incidence. We performed univariate and multivariate analyses to identify predictive factors for PPRC.

Result

Postoperative pancreas-related complications occurred in 11 patients (5.4%). The median of the optimal cutoff GPC value for predicting PPRC was 0 mm; therefore, we classified the GPC status into two groups: GPC plus group and GPC minus group. Univariate analysis revealed that sex (male), C-reactive protein (CRP) > .07 mg/dl, GPC plus, and visceral fat area (VFA) > 99 cm2 were associated with the development of PPRC. Multivariate analysis identified only GPC plus as independent predictor of PPRC (hazard ratio: 4.60 [95% confidence interval 1.11-31.15], P = .034).

Conclusion

The GPC is a simple and reliable predictor of PPRC after LG. Surgeons should evaluate GPC status on preoperative CT images before proceeding with laparoscopic gastric cancer surgery.
Introduction: The Waste of Conflict. The Conflicts of Waste
Authors: Borowy Iris , Pal Viktor , Zimring Carl
Published: April 2024

Throughout human history, people have always produced waste, but during the last century, this has shown explosive growth. Globally, a combination of rising incomes, urbanization, the development of new, cheap materials, and changing lifestyles have driven the growth of products that were designed to be used for only limited periods of time producing a totally unprecedented amount and variety of waste. However, this development has not affected all people in similar ways. Waste has been a marker of unprecedented but unbalanced efficiency, wealth and power, and conflict. Five articles address waste as a function of conflicts in areas in various places in Europe and Asia. Collectively, these papers shed an unusual light on the twentieth century world through a collection of cases, in which conflicts have tended to exacerbate challenges of waste, either by increasing the quantity of weapons and their (often toxic) remains, or by creating contexts in which the confrontation with adversaries often relegated environmental, social and health-related consideration to the backstage.
Research on the grasping characteristics of composite-driven double-finger flexible manipulator
Authors: Li Taotao , Chen Jianping
Published: April 2024

Aiming at the flexible manipulator grasping complex target parts of different shapes, a double-finger flexible manipulator model is proposed. The manipulator is composed of a flexible mechanical finger, a driving component and a position compensation mechanism. It imitates the motion characteristics of human finger joints and follows the principle of double-fingered grasping. According to the structural characteristics of the target contour, the grasping features of the target contour are extracted. Through the motion principle of the flexible manipulator, the kinematic model of the envelope clamping process of the manipulator target is carried out. Finally, the flexible manipulator experimental platform is built to verify the grasping characteristics of the flexible manipulator target. The results show that the manipulator can realize the adaptive grasping of cylinder and cuboid parts, which have high grasping reliability and stability.
Implementation of a 3-phase grid-coupled solar electricity and back-up system at Mulanje Mission Hospital, Malawi
Authors: Glas Arie C , Cocquyt Michael J , Ratcliff Cathy
Published: April 2024

In this report we describe the implementation of a new electricity supply system at Mulanje Mission Hospital, Malawi, which integrates the use of grid electricity, solar-generated electricity and battery back-up. To realize the system, suppliers from several countries had to be used and external expertise and funding were vital. The completed system provides reliable and good quality electricity to all departments in the hospital, prioritizing essential equipment when needed. Implementation of the system has reduced cost of electricity bills by 60%, ended black-outs and extended longevity of electrical equipment. We describe our approach, the materials used and results with challenges and recommendations to governments, donors interested in hospital infrastructure and other health facilities operating in similar circumstances. Others in similar settings can benefit from the experiences documented.
The Status of Status Research: A Review of the Types, Functions, Levels, and Audiences
Authors: Prato Matteo , Ertug Gokhan , Castellucci Fabrizio , Zou Tengjian
Published: April 2024

Our review of 154 articles published over the last decade portrays an evolution of status research. This body of literature has transitioned from viewing status as a monolithic construct to appreciating its inherently multidimensional nature, characterized by diverse types, functions, levels, and audience structures. Although this shift has expanded our knowledge, it has also introduced increased complexity and fragmentation. To systematize this scattered work on a multifaceted view of status, we develop a comprehensive framework that integrates the diverse research findings. For each constituent part of this framework, we review key themes and insights in the literature and outline future research directions. Our goal is to provide a clear roadmap to navigate the increasing complexity of status research, encouraging more precise theorizing and transversal exploration across the different dimensions of status.
Effect of powder characteristics on the microstructure and performance of CuSn10 parts by material extrusion 3D printing
Authors: Jin Kai , Zheng Su , Li Gemin , Cheng Jigui
Published: April 2024

Two water-atomised, one gas-atomised and treated CuSn10 powders were employed as initial materials to prepare bronze products by material extrusion (MEX) printing technology. The results highlight a significant impact of powder morphology and particle size on both the microstructure and mechanical performance of CuSn10 products. Among the single-size powders, the 3D printed parts, utilising −1000 mesh gas-atomised CuSn10 powders as raw materials, achieved a remarkable hardness of 76.5 HB. For dual-granularity CuSn10 powders, the printed parts from 80%/400500 mesh and 20%/−1000 mesh powders have the optimal performance, reaching a relative density of 98.88% and tensile strength of 355.46 MPa. Successful printing and sintering of various gear parts underscore MEX printing as a viable method for producing high-performance bronze components.
High intensity focused ultrasound in treating great saphenous vein incompetence: Perioperative and 1-year outcomes
Authors: Casoni Paolo , Bissacco Daniele , Pizzamiglio Matteo , Nanni Emanuele
Published: April 2024

Background

To investigate the use of high intensity focused ultrasound (HIFU) for great saphenous vein (GSV) incompetence.

Material and methods

Patients with GSV incompetence underwent HIFU. The primary endpoint was the rate of GSV target segment shrinkage or closure after 1 year.

Results

Out of 188 limbs treated, the GSV treated segment shrinkage/closure rate at 1 week, 3 months, 6 months, and 12 months was 93.3%, 98.2%, 97.6%, and 98.3%, respectively.

Conclusion

These preliminary results suggest that HIFU holds promise for the treatment of GSV incompetence. Further trials are needed to compare it with other techniques and assess long-term outcomes.
Deep Learning for Exploring the Relationship Between Geotechnical Properties and Electrical Resistivities
Authors: Zamanian Mina , Asfaw Natnael , Chavda Prakash , Shahandashti Mohsen
Published: April 2024

Electrical resistivity imaging is gaining popularity in aiding the characterization of subsurface conditions and assessment of the stability of earth materials. Nevertheless, it remains challenging to identify the relationship between geotechnical properties and electrical resistivities because of their nonlinear and complex relationship. This study intends to assess the application of the deep learning model to explore the relationship between electrical resistivities and geotechnical properties of natural clayey soils. A full factorial design was used to study the effects of water content and dry unit weight on the electrical resistivities of soils composed of different fractions of fine and clay particles. A deep learning model with three hidden layers was trained using a dataset comprising 842 observations to investigate the association between electrical resistivities and geotechnical properties. Influencing geotechnical properties were identified by Spearman’s correlation and feature importance. The results show that most variabilities in the electrical resistivity can be explained by the water content and dry unit weight. The results also show that the plasticity index and fine fraction play a more substantial role in predicting the electrical resistivities of clayey soils than the liquid limit and clay fraction. A comparison between the accuracy metrics of the deep learning model with existing models in the literature shows that deep learning outperforms other models in discovering nonlinear and complex relationships between electrical resistivities and geotechnical properties. Enhanced knowledge of the relationship between geotechnical properties and electrical resistivities allows for better characterizing the subsurface conditions to improve reliability and reduce uncertainties caused by inadequate subsurface information.
Effects of Foldable Containers in Various Circumstances in Maritime Transport
Authors: Kim Minsu , Lu Bo , Moon Ilkyeong
Published: April 2024

This paper analyzes the effect of foldable containers in various circumstances. Recently, as a result of the COVID-19 pandemic, many unexpected situations have arisen in the shipping and logistics industries. In this study, we examine three key situations: shutdowns, demand fluctuations, and fleet size fluctuations. Furthermore, we developed an integer programming model to analyze through experiments the effect of foldable containers in each situation. The results show that foldable containers have proven to be more effective than standard containers in many situations, and they facilitate a faster recovery from container imbalances. However, the optimal number of foldable containers differs in each situation, and the cost of foldable containers is high. To address this, we propose implementing effective container usage through lease policies. Additionally, we explore management countermeasures from the perspective of each market participant to expand the foldable container market.