bluuebunny/crossref_metadata_2025 huggingface dataset:
Meta‐Analysis of Counseling Outcomes for Youth With Conduct Disorders
Authors: Erford Bradley T. , Bardhoshi Gerta , Ross Margaret , Gunther Chelsea , Duncan Kelly
Published: January 2017

Twenty‐one clinical trials were synthesized using a random‐effects model, which substantiated that counseling generally produces a medium effect in treating conduct disorder in youth at termination (d+ = 0.30 to 0.57; k = 28). However, the lasting effects at follow‐up were unclear because few follow‐up studies (k = 13) have been conducted (d+ = −0.53 to 0.58), and only 2 randomized controlled follow‐up studies were located. No effects of moderating variables were evident. Implications for counseling practice and outcome research are addressed.
Women in the National Guard: Coping and Barriers to Care
Authors: Maung Joanna , Nilsson Johanna E. , Berkel LaVerne A. , Kelly Patricia
Published: January 2017

This study involved interviews with 42 women from the National Guard about their experiences of coping during reintegration into civilian life. Data were analyzed using techniques of conventional content analysis. The 1st theme that emerged regarded barriers to seeking and accessing care (institutional barriers, personal barriers, and stigma). The 2nd theme, coping strategies, consisted of 4 categories (seeking or gaining professional help, seeking social support, using routine activities, and using aspects of religion/spirituality). Implications for clinical work with returning female soldiers are discussed.
College and Career Readiness Counseling Support Scales
Authors: Lapan Richard T. , Poynton Timothy , Marcotte Amanda , Marland Joshua , Milam Chase M.
Published: January 2017

This study presents initial evidence supporting the factor structure and criterion validity of the College and Career Readiness Counseling Support scales. Graduating 12th graders' ratings of both the frequency and helpfulness of meetings with counselors were correlated with malleable factors related to achievement in high school and with important markers of postsecondary success approximately 18 months after students graduated from high school. The scales can be used to help students self‐advocate and to evaluate counseling services.
New Concepts in the 2014 ACA Code of Ethics
Authors: Kaplan David M. , Francis Perry C. , Hermann Mary A. , Baca Jeannette V. , Goodnough Gary E. , Hodges Shannon , Spurgeon Shawn L. , Wade Michelle E.
Published: January 2017

The 2014 revision of the ACA Code of Ethics (American Counseling Association [ACA], ) substantially raises the bar for the ethical practice of professional counselors. This article provides interviews with members of the ACA Ethics Revision Task Force that explore and clarify new imperatives in the areas of ethical decision making, professional values, managing and maintaining boundaries, technology (including social media), the nonimposition of counselor personal values, counselor education, legal issues, sliding scales, and fee splitting.
New age constraints for the limit of the British–Irish Ice Sheet on the Isles of Scilly
Authors: Smedley R. K. , Scourse J. D. , Small D. , Hiemstra J. F. , Duller G. A. T. , Bateman M. D. , Burke M. J. , Chiverrell R. C. , Clark C. D. , Davies S. M. , Fabel D. , Gheorghiu D. M. , McCarroll D. , Medialdea A. , Xu S.
Published: January 2017

The southernmost terrestrial extent of the Irish Sea Ice Stream (ISIS), which drained a large proportion of the last British–Irish Ice Sheet, impinged on to the Isles of Scilly during Marine Isotope Stage 2. However, the age of this ice limit has been contested and the interpretation that this occurred during the Last Glacial Maximum (LGM) remains controversial. This study reports new ages using optically stimulated luminescence (OSL) dating of outwash sediments at Battery, Tresco (25.5 ± 1.5 ka), and terrestrial cosmogenic nuclide exposure dating of boulders overlying till on Scilly Rock (25.9 ± 1.6 ka), which confirm that the ISIS reached the Isles of Scilly during the LGM. The ages demonstrate this ice advance on to the northern Isles of Scilly occurred at ∼26 ka around the time of increased ice‐rafted debris in the adjacent marine record from the continental margin, which coincided with Heinrich Event 2 at ∼24 ka. OSL dating (19.6 ± 1.5 ka) of the post‐glacial Hell Bay Gravel at Battery suggests there was then an ∼5‐ka delay between primary deposition and aeolian reworking of the glacigenic sediment, during a time when the ISIS ice front was oscillating on and around the Llŷn Peninsula, ∼390 km to the north. Copyright © 2017 The Authors. Journal of Quaternary Science Published by John Wiley & Sons, Ltd.
The sedimentary history of the inner‐alpine Inn Valley, Austria: extending the Baumkirchen type section further back in time with new drilling
Authors: Barrett Samuel , Starnberger Reinhard , Tjallingii Rik , Brauer Achim , Spötl Christoph
Published: January 2017

The Baumkirchen clay pit near Innsbruck, western Austria, is a well‐known site in Alpine Quaternary stratigraphy. Lacustrine sediments from the last glacial cycle from within the Alps provide a unique opportunity to investigate the regional palaeoclimate. Recent drilling has extended the known sequence to a total length of at least 250 m consisting of almost entirely well‐laminated clayey silt. Luminescence dating identified two lake sequences, separated by a hiatus of ca. 7000–15 000 years. Lake phase 1 spans the period ca. 77–55 ka, i.e. from about Marine Isotope Stage (MIS) 5/4 to the MIS 4/3 transition. Lake phase 2 extends from mid‐ to late MIS 3 between ca. 45 and 33 ka. Down‐core X‐ray fluorescence core scanning confirmed the presence of the lake phases in the sediment composition, suggesting different sediment sources and/or transport mechanisms during these two intervals. A unique section of exotic, angular, silt matrix‐supported gravel at the top of lake phase 1 is interpreted as ice‐rafted debris. Luminescence dating constrains this layer to ca. 55 ka, thus providing the first evidence of a late MIS 4 or early MIS 3 ice advance confined to the interior of the Eastern Alps. A conceptual model of the sedimentary history of the valley is presented.
Comparative investigation of the vibrational properties of bulk 2H–MoS2 and its exfoliated nanosheets under high pressure
Authors: Guo Zhiying , Dong Juncai , Zhu Hailing , Gong Yu , Li Pengshan , Yang Dongliang , Shan Xuemei , Wang Yan , Zheng Lei , Zhao Yidong , Li Xiaodong , Chen Dongliang
Published: January 2017

In this paper, we present a comparative study of the vibrational properties of bulk MoS2 and its exfoliated nanosheets under high pressure by resonant Raman spectroscopy. The X‐ray photoelectron spectroscopy measurements demonstrate that the nanosheets made by chemical lithium insertion method are mainly consisted of metallic 1T phase. The wavenumbers of the
and Alg Raman modes for the few layer nanosheets show a linear relationship with pressure which is different from the multilayer MoS2. This phenomenon is due to the differences in their electronic band structure. The systematic research about the 2LA (M) in bulk 2H–MoS2 suggests that the high pressure behaviour of this double resonance Raman mode arises from the pressure‐induced metallization and band gap closure. These difference vibrational properties for few and multilayer MoS2 can be applied for exploring pressure‐modulated advanced devices. Copyright © 2017 John Wiley & Sons, Ltd.
The role of oncoplastic breast reduction in the conservative management of breast cancer: Complications, survival, and quality of life
Authors: Acea‐Nebril Benigno , Cereijo‐Garea Carmen , García‐Novoa Alejandra , Varela‐Lamas Cristina , Builes‐Ramírez Sergio , Bouzón‐Alejandro Alberto , Mosquera‐Oses Joaquín
Published: January 2017

Background and Objectives

Reduction Mammaplasty (RM) in breast cancer allows mammary remodeling after wide excisions. We aimed to analyze the complications, survival, and quality of life after RM.

Methods

Retrospective study of women who underwent a surgical intervention for breast cancer between 2000 and 2016. Patients were divided into two groups: RM and tumorectomy. Postoperative complications, survival and quality of life were assessed using the Breast‐Q questionnaire.

Results

A total of 801 patients were evaluated, with a mean follow up of 84 months. RM patients experienced a longer operating time and hospital stay, and a higher proportion of tissue necrosis compared to tumorectomy patients (P < 0.001). No significant differences were observed regarding rate of re‐excision or rate of mastectomy, but the recurrence rate at 10 years was higher for RM patients (P < 0.03). Patients who underwent RM reported optimal satisfaction with the breast and a good quality of life.

Conclusions

RM is a useful approach in breast cancer surgery, with a low rate of re‐excision and mastectomy. Overall survival at 10 years is similar to that associated with tumorectomy, though with a higher rate of local recurrence. Patient satisfaction and quality of life appears to be good one year after radiotherapy.
Post‐mastectomy radiation therapy and overall survival after neoadjuvant chemotherapy
Authors: Kantor Olga , Pesce Catherine , Singh Puneet , Miller Megan , Tseng Jennifer , Wang Chi‐Hsiung , Winchester David J. , Yao Katharine
Published: January 2017

Background

The role of postmastectomy radiation therapy (PMRT) after neoadjuvant chemotherapy (NAC) and mastectomy is unclear, especially in patients that have post‐treatment tumor negative axillary nodes (ypN0).

Methods

The National Cancer Data Base was used to identify women that had PMRT after NAC and mastectomy for clinically node positive (cN1‐2) disease from 2004 to 2008. Median follow‐up time was 69 months.

Results

8,321 patients were included for analysis, and 6140 (65.6%) had cN1 disease and 2181 (23.3%) had cN2 disease. On adjusted survival analysis, PMRT was associated with an overall survival (OS) benefit in both patients with cN1 (5‐yr OS 75.8% vs. 71.9%, P < 0.01) and cN2 (5‐yr OS 69.2% vs. 58.6%, P < 0.01) disease. In the subgroup of patients that were ypN0 after NAC, there was no significant survival difference (P > 0.11) for PMRT compared to those patients who were not ypN0, except for patients with hormone‐receptor negative tumors, who had improved OS with PMRT (HR 0.65, P < 0.01).

Conclusions

PMRT is associated with improved OS in patients with cN1 and cN2 disease after NAC and mastectomy. However, in the subgroup of patients that were ypN0 after NAC, PMRT improved OS for hormone‐receptor negative patients but not hormone‐receptor positive patients.
Unpacking Directions and Spatial Patterns of VFR Travel Mobilities in the Global South: Insights from South Africa
Authors: Rogerson Christian M.
Published: January 2017

Unpacking the spatial patterns of visiting friends and relatives (VFR) mobilities within (and between) countries represents an investigatory void in existing international VFR scholarship. The paper seeks to interrogate the relationships between historical and contemporary migration flows and VFR travel by using the case of South Africa. The study highlights the importance of understanding the role of multi‐locational households, the roots and persistence of circulatory migration flows and their manifestations in the present‐day geography of VFR travel mobilities in post‐apartheid South Africa. Interpreting the changing spatial patterns of VFR travel must be grounded in the historical and contemporary dynamics of local and regional migration systems. For South Africa's poorest areas where VFR travel flows are the dominant if sometimes the only form of tourism, policy issues arise for leveraging this form of tourism for enhancing local development. Copyright © 2017 John Wiley & Sons, Ltd.
Testimony Therapy With Ritual: A Pilot Randomized Controlled Trial*
Authors: Esala Jennifer J. , Taing Sopheap
Published: January 2017

Testimony therapy can provide low‐cost, brief, simple, and culturally adaptable psychosocial services in low‐income countries (Agger, Raghuvanshi, Khan, Polatin, & Laursen, 2009). Nonetheless, there have been no well‐controlled studies of testimony therapy. We report the analyses of a randomized controlled trial designed to assess the effectiveness of testimony therapy plus a culturally adapted ceremony in reducing mental health symptoms among Khmer Rouge torture survivors from across Cambodia. Using multilevel modeling, we compared symptoms of posttraumatic stress disorder, anxiety, and depression between a treatment (n = 45) and a control group (n = 43) at baseline, 3 months, and 6 months. We found that testimony therapy plus ceremony significantly reduced symptoms of posttraumatic stress disorder (d = 0.49), anxiety (d = 0.44), and depression (d = 0.53).
Acceptance of Smartphone‐Based Mobile Shopping: Mobile Benefits, Customer Characteristics, Perceived Risks, and the Impact of Application Context
Authors: Hubert Marco , Blut Markus , Brock Christian , Backhaus Christof , Eberhardt Tim
Published: January 2017

Despite their generally increasing use, the adoption of mobile shopping applications often differs across purchase contexts. In order to advance our understanding of smartphone‐based mobile shopping acceptance, this study integrates and extends existing approaches from technology acceptance literature by examining two previously underexplored aspects. First, the study examines the impact of different mobile and personal benefits (instant connectivity, contextual value, and hedonic motivation), customer characteristics (habit), and risk facets (financial, performance, and security risk) as antecedents of mobile shopping acceptance. Second, it is assumed that several acceptance drivers differ in relevance subject to the perception of three mobile shopping characteristics (location sensitivity, time criticality, and extent of control), while other drivers are assumed to matter independent of the context. Based on a dataset of 410 smartphone shoppers, empirical results demonstrate that several acceptance predictors are associated with ease of use and usefulness, which in turn affect intentional and behavioral outcomes. Furthermore, the extent to which risks and benefits impact ease of use and usefulness is influenced by the three contextual characteristics. From a managerial perspective, results show which factors to consider in the development of mobile shopping applications and in which different application contexts they matter.
Effects of Blue Lighting in Ambient and Mobile Settings on the Intention to Buy Hedonic and Utilitarian Products
Authors: Guido Gianluigi , Piper Luigi , Prete M. Irene , Mileti Antonio , Trisolini Carla M.
Published: January 2017

According to multidisciplinary research, the blue light has important consequences for human beings’ productivity and well‐being, as it positively influences their circadian, endocrine, and neurobehavioral functions. This paper examines how blue light—in both the physical environment and a mobile display—influences consumers’ purchase intentions in mobile shopping. Specifically, this paper proposes that consumers who are exposed to certain conditions of blue lighting (identified by an emission spectrum centered at 460 nm; i.e., “actinic blue”), in either a room environment or via a smartphone, are more inclined to purchase hedonic rather than utilitarian products. After describing the study, which compares the effects of blue lighting to more traditional white lighting (identified with an emission spectrum centered at 635 nm; i.e., “warm white”), the paper discusses results, alongside the implications for theory, marketing practice, and future research.
Neoagarotetraose protects mice against intense exercise‐induced fatigue damage by modulating gut microbial composition and function
Authors: Zhang Na , Mao Xiangzhao , Li Robert W. , Hou Enling , Wang Yuming , Xue Changhu , Tang Qingjuan
Published: January 2017

Scope

Exhaustive exercise stress has emerged as an important health issue, and gastrointestinal problems are a common concern during intense exercise. In this study, we investigated the potential antifatigue effects of neoagarotetraose (NAT) in mice under intense exercise stress.

Materials and methods

Exhaustive exercise stress significantly weakened several physiological and physical parameters of the mice, including decreased food intake, reduced body weight, and impaired integrity of the intestinal epithelial barrier. Our data showed that a 16‐day NAT treatment resulted in a profound change in microbiome composition, which subsequently led to widespread shifts in the functional potential of the gut microbiome. Furthermore, NAT administration significantly increased the fecal concentration of total short‐chain fatty acids (p < 0.01).

Conclusion

Together, our findings suggest that NAT may protect mice against intense exercise‐induced fatigue and provide insights into the mechanisms of NAT as a potential prebiotic.
Electromagnetic computation and modeling in MRI
Authors: Chen Xin , Steckner Michael
Published: January 2017

Electromagnetic (EM) computational modeling is used extensively during the development of a Magnetic Resonance Imaging (MRI) scanner, its installation, and use. MRI, which relies on interactions between nuclear magnetic moments and the applied magnetic fields, uses a range of EM tools to optimize all of the magnetic fields required to produce the image. The main field magnet is designed to exacting specifications but challenges in manufacturing, installation, and use require additional tools to maintain target operational performance. The gradient magnetic fields, which provide the primary signal localization mechanism, are designed under another set of complex design trade‐offs which include conflicting imaging performance specifications and patient physiology. Gradients are largely impervious to external influences, but are also used to enhance main field operational performance. The radiofrequency (RF) magnetic fields, which are used to elicit the signals fundamental to the MR image, are a challenge to optimize for a host of reasons that include patient safety, image quality, cost optimization, and secondary signal localization capabilities. This review outlines these issues and the EM modeling used to optimize MRI system performance.
Propacetamol poses a potential harm of adverse hypotension in male and older patients
Authors: Lee Hyun‐Young , Ban Ga‐Young , Jeong Chang‐Gyu , Lee Ji‐Ho , Park Seung‐Hee , Kim Sang‐Hee , Lee Young‐Hee , Ye Young‐Min
Published: January 2017

Purpose

Researchers recently suggested intravenous paracetamol as a potential cause of hypotension. We aimed to investigate risk factors of paracetamol‐ and propacetamol‐associated adverse drug reactions (ADRs) in Korean individuals.

Methods

All adverse hypotension cases, regardless of suspected drug, and all ADRs associated with paracetamol and propacetamol use were collected from the Korea Adverse Event Reporting System database between 2011 and 2014. The seriousness, causality, and type of ADR were classified.

Results

Of 4,771 cases of adverse hypotension, 403 (8.4%) were reported to be related to propacetamol. This was comparable to the rate of hypotension associated with fentanyl (454, 9.5%), the major suspected drug of hypotension. Paracetamol‐associated hypotension accounted for merely 1.2% (55 cases) of all hypotension cases. Among ADRs associated with propacetamol use, hypotension was the most common (37.1%), whereas cutaneous reactions were the primary paracetamol‐associated ADR. Propacetamol/paracetamol‐associated hypotension was frequently recorded in older patients (≥54 years) (53.9 ± 25.8 vs. 42.8 ± 21.7, P < 0.001) and taking more concomitant drugs (1.9 ± 5.0 vs. 1.1 ± 3.2, P < 0.001). Also, compared with other ADRs associated by propacetamol/paracetamol, hypotension was more commonly assessed as a serious outcome (27.3% vs. 11.4%, P < 0.001). Regarding concomitant medications, the risk for hypotension associated with propacetamol was significantly increased in patients simultaneously taking antibacterials (J01), cold preparations (R05), drugs for acid related disorders (A02), blood substitutes (B05), or antithrombotics (B01).

Conclusions

Propacetamol was found to be a major suspected drug of pharmacologically associated hypotension in Korea. Older and male patients taking medications in combination with propacetamol/paracetamol should undergo monitoring of their blood pressure. Copyright © 2017 John Wiley & Sons, Ltd.
Treatment of Adults with Idiopathic Recurrent Pericarditis: Novel Use of Immunotherapy
Authors: Schwier Nicholas C. , Hale Genevieve M. , Davies Marie L.
Published: January 2017

Idiopathic recurrent pericarditis (IRP) can be challenging to treat. Even after guideline‐directed first‐line treatment consisting of aspirin (ASA) or a nonsteroidal antiinflammatory drug (NSAID) in combination with colchicine therapy, recurrences still occur in greater than 20% of patients. Many patients then require treatment with long‐term corticosteroids, which is not a favorable option due to their short‐ and long‐term adverse effects. Because it is theorized that the pathophysiology of IRP may possess autoimmune sequelae, the use of immunotherapy for the treatment of IRP has emerged. In this review, we describe the literature associated with immunotherapy used to treat IRP in an adult population as well as provide an overview of the safety and monitoring parameters for each agent. The most common immunotherapies used after patients have had multiple recurrences of IRP are anakinra, intravenous immunoglobulin (IVIG), and azathioprine. In most cases, these immunotherapies are adjunctive therapy, with the goal of tapering and discontinuing immunosuppressive corticosteroids. After reviewing the data, anakinra resulted in more patients discontinuing corticosteroids and prevented further recurrences of pericarditis. IVIG resulted in symptom resolution and no further recurrences in most of the patients. Azathioprine was associated with more than half of patients becoming recurrence free; however, many patients required a restart of corticosteroids due to recurrence. Clinicians should be aware of the adverse effects of immunotherapy, ranging from mild gastrointestinal events to risk of infection and serious blood dyscrasias that may require diligent monitoring. The use of immunotherapy for the treatment of adults with IRP should be restricted to patients who have multiple recurrences. Ideally, immunotherapy would be adjunctive to first‐line combination therapy with ASA/NSAID plus colchicine, with the goal of tapering and discontinuing immunosuppressive corticosteroids. Furthermore, clinicians should consider cost, drug‐drug and drug‐disease interactions, and safety, as well as the quality of the retrospective evidence before considering any immunotherapy.
Risk of Mortality in Elderly Nursing Home Patients with Depression Using Paroxetine
Authors: Bali Vishal , Chatterjee Satabdi , Johnson Michael L. , Chen Hua , Carnahan Ryan M. , Aparasu Rajender R.
Published: January 2017

Objective

Among selective serotonin reuptake inhibitors (SSRIs), paroxetine is strongly anticholinergic and might lead to a higher risk of adverse outcomes such as mortality. This study examined the risk of mortality in depressed elderly nursing home patients using paroxetine and other SSRIs.

Methods

This study used 2007–2010 Minimum Data Set–linked Medicare data and a propensity score (PS)‐matched retrospective cohort study design to achieve the study objective. New users of paroxetine and other SSRIs were followed until they reached the end of the follow‐up period (1 year), switched to a different antidepressant class, used psychotherapy, or had a gap of more than 15 days in the use of index antidepressant class, whichever occurred earlier. A robust Cox proportional hazard (PH) model was used to evaluate the risk of mortality associated with the use of paroxetine and other SSRIs in depressed elderly nursing home residents.

Results

The PS matching yielded 4620 patients each in the two treatment groups. The unadjusted incidence of mortality was 269 (2.9%) for paroxetine and 288 (3.1%) for other SSRIs users in the matched cohort. The robust Cox PH model did not find any significant difference in the risk mortality between the two groups (hazard ratio 1.01; 95% confidence interval 0.86–1.19).

Conclusions

This study did not find any significant difference in the risk of mortality between users of paroxetine and other SSRIs among elderly nursing home patients with depression. There is a need for further evaluation of other adverse effects of paroxetine due to its anticholinergic effects in the geriatric population.
Aggregation‐Induced Emission for Highly Selective and Sensitive Fluorescent Biosensing and Cell Imaging
Authors: Huang Liang , Dai Liming
Published: January 2017

Fluorescent bioprobes are powerful analytical tools for studying biological activities in living systems. Fluorogens with aggregation‐induced emission (AIE) characteristics have recently emerged as a new class of fluorescent bioprobes for biosensing and cell imaging. As discovered by Tang, AIE fluorogens are nearly nonemissive in molecular states with their intermolecular rotations being not restricted whereas their fluorescence is turned on by binding with certain biomolecules, leading to highly selective turn‐on fluorescent probes for specific biomolecules and fluorescent cell imaging with a high signal‐to‐background noise ratio. By introducing the AIE characteristics into polymeric materials, AIE polymers could possess a good solubility and biocompatibility, excellent structural diversity, and ease for functionalization useful for efficient biosensing and cell imaging. Herein, we highlight a few recently published articles on small and macromolecular AIE molecules to provide a fundamental understanding of the AIE mechanism and illustrate the working principle for AIE based biosensing and cell imaging. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 653–659
An Improved Process Towards Hexahydro‐1,3,5‐trinitroso‐1,3,5‐triazine (TNX)
Authors: Rothstein Sarah A. , Dubé Pascal , Anderson Stephen R.
Published: January 2017

Hexahydro‐1,3,5‐trinitroso‐1,3,5‐triazine (TNX) is mostly known as a by‐product in the environmental decomposition of RDX. The original chemistry to TNX was never optimized and thus resulted in low yields due to competitive degradation of the starting material. Enabled conditions to TNX were developed by optimizing pH effects and mitigating foaming by reactor geometry and stirring. The conditions presented herein allow for the inexpensive and simple production of multi‐gram quantities of TNX. The isolated TNX obtained by our new method was characterized by 1H NMR, 13C NMR, DSC, and X‐ray crystallography. A preliminary evaluation of the sensitivity of TNX towards impact and friction is also presented.
Promising Antimicrobial Activity of an Oxime Based Palladium(II) Complex
Authors: Bandyopadhyay Nirmalya , Das Mousumi , Samanta Amalesh , Zhu Miaoli , Lu Liping , Naskar Jnan Prakash
Published: January 2017

This work delineates with the development of a novel oxime based palladium complex as a promising antimicrobial agent. A novel oxime based ligand, 3‐[(2‐hydroxy‐naphthalen‐1‐ylmethylene)‐hydrazono]‐butan‐2‐one oxime (LH), has been employed to synthesize an orange, monomeric, diamagnetic palladium(II) compound, [Pd(L)(Cl)] (1) in moderate yield. LH is a mono‐condensate Schiff‐base of 2,3‐butanedionemonoxime monohydrazone and 2‐hydroxy‐1‐naphthaldehyde in tetrahydrofuran. Both the ligand and its palladium compound have been characterized by spectroscopic and analytical techniques. The X‐ray crystal structure of 1 reveals that the palladium center in [Pd(L)(Cl)] is nested in a distorted square‐planar ‘N2OCl’ coordination environment. The electrochemical behavior of [Pd(L)(Cl)] in DMF shows a Pd(II)/ Pd(I) irreversible reduction couple. The in vitro antibacterial activity of [Pd(L)(Cl)] was tested against a good number of human pathogenic Gram‐positive and Gram‐negative bacterial cell lines. The in vitro antifungal activity of the titled palladium compound was screened against several pathogenic fungal strains. The promising antimicrobial efficacy of the palladium compound was corroborated through SEM study.
N‐Acylbenzotriazole as Efficient Ligand in Copper‐Catalyzed O‐Arylation Leading to Diverse Benzoxazoles
Authors: Singh Anoop S. , Singh Mala , Mishra Nidhi , Mishra Snigdha , Agrahari Anand K. , Tiwari Vinod K.
Published: January 2017

An establishment of (1H‐benzo[d][1,2,3]triazol‐1‐yl)(2‐methoxyphenyl)methanone as ligand was attained in intramolecular C‐O cross‐coupling of N‐(2‐halophenyl)aryl/alkylamide derivatives to form 2‐Aryl/alkyl benzoxazole derivatives using CuI/K2CO3 as catalytic system. A series of benzoxazoles was developed using this protocol and synthesized compounds were characterized using spectroscopic analysis (IR, MS, 1H & 13C NMR). Salient advantages associated with this pathway include easily available starting materials, cheap catalyst, highly stable ligand, wide substrate scope, smooth reaction, easy work‐up and high product yield.
Anticancer Activity and DNA Binding Studies of Novel 3,7‐Disubstituted Benzopyrones
Authors: Durgapal Sunil Dutt , Soni Rina , Umar Shweta , Suresh Balakrishnan , Soman Shubhangi S.
Published: January 2017

We have designed and synthesized novel 7‐substituted‐3‐acetyl‐benzopyrones 9 a‐9 g and ethyl 7‐substituted‐3‐carboxylate‐benzopyrones 10 a‐10 d and screened for anticancer activity using MTT assay. Most of the tested compounds have shown very good activity against A549 cell line (lung cancer cell‐line) and MCF7 cell line (breast cancer cell‐line) compared to 5‐Fluorouracil. Compound 9 b and 9 e exhibited excellent anticancer activity with IC50 0.16 nM against A549 cell line and 84.8 nM against MCF7 cell line respectively. Compounds 9 b and 9 e showed excellent anticancer activity at very low concentration, well falling in nanomolar region. Compounds 9 b and 9 e exhibited very good binding constant for DNA binding through intercalation in UV based DNA titration which was further confirmed by fluorescence based EtBr displacement assay in DNA‐EtBr complex.
Symbiotic Interaction of Amalgamated Photocatalysts with Improved Day Light Utilisation and Charge Separation
Authors: Leong Kah Hon , Tan Zhu Zhin , Sim Lan Ching , Saravanan Pichiah , Bahnemann Detlef , Jang Min
Published: January 2017

A promising amalgamation of organic with inorganic semiconductor photocatalyst (g‐C3N4/SrTiO3) with varied g‐C3N4 concentration was synthesised through a simple thermal method. The organic semiconductor was prepared through a facile pyrolysis of urea while perovskite (SrTiO3) by sol‐gel hydrothermal route. The observed mechanistic characteristics of the synthesised composite photocatalysts were thoroughly analysed through robust analytical tools. The dissection analysis clearly revealed that amalgamation of organic semiconductor stimulated the utilisation of solar spectrum by enhancing the light absorption towards visible band. Where else perovskite activated close interfacial connections leading to enhanced efficiency of electron migration. The Electron Paramagnetic Resonance (EPR) excited under solar spectrum along with Photoluminescence (PL) clearly indicated the prolongation of the charge carriers. A symbiotic interaction with mutual benefit was clearly observed between these photocatalysts. The solar photocatalysis ability of the perovskite composite was examined by degrading a non‐photosensitising compound (Bisphenol A). The photocatalysis experiment clearly revealed its dominant solar light harvesting capability of the developed perovskite amalgamated organic photocatalyst.
Behavior of Intramolecular π‐π Interactions with Doubly Degenerated Bond Paths Between Carbon Atoms in Opposite Benzene Rings of Diethenodihydronaphthalenes by QTAIM Approach
Authors: Matsuiwa Kohei , Sugibayashi Yuji , Tsubomoto Yutaka , Hayashi Satoko , Nakanishi Waro
Published: January 2017

Dynamic and static nature of intramolecular π‐π interactions between ethylene moieties in diethenodihydronaphthanaphtalene (1 b) and derivatives (2 b–12 b) are elucidated by employing QTAIM‐DFA (QTAIM dual functional analysis). During the course of the investigations, doubly degenerated bond paths were detected between carbon atoms in opposite benzene rings of dibenzo‐derivative of 1 b with an etheno‐bridge on the backside (11 b). It must be very curious, since one BP should correspond to an interaction between two carbon atoms. Intramolecular π‐π interactions in 1 b–12 b are all classified by the pure CS (closed shell) interactions. The interactions between ethylene groups, with no substituents as in 1 b–8 b, are predicted to have the van der Waals (vdW) nature. Those for 9 b–12 b have the hydrogen bond (HB) nature with no covalency, where the ethylene moieties are included in one or two benzene ring(s), except for 10 b, if evaluated with MP2/6‐311G(3d). The character in 10 b is close to the borderline area between the vdW and HB nature with no covalency, although should be the vdW type. The interactions in 2 b–12 b evaluated with MP2/6‐311G(3d) are predicted to be somewhat stronger than the case with MP2/6‐311G(d), as a whole.
Decoralin Analogs with Increased Resistance to Degradation and Lower Hemolytic Activity
Authors: Torres Marcelo D. T. , Pedron Cibele N. , Araújo Iris , Silva Pedro I. , Silva Fernanda D. , Oliveira Vani X.
Published: January 2017

Decoralin is an antimicrobial peptide with activity against microorganisms and pronounced hemolytic activity. Decoralin analogs have been proposed, and the results indicated that when isoleucine at position 6 was substituted by phenylalanine residue, the peptides exhibited increased resistance towards enzymes action. Besides that, lower hemolytic activity was obtained for [Pro]4‐Decoralin‐NH2 and [Phe]6‐Des[Thr]11‐Decoralin‐NH2; this effect is probably due to their poor helical tendency. [Arg]1‐Decoralin‐NH2 exhibited +4 net charge and lower hemolytic activity (25.0 μmol L−1) and even showed helical propensity; as a consequence, it presented the higher therapeutic indexes (values from 16.0 to 32.0). The helical conformational tendency is believed to be determinant of the antimicrobial activity of this decoralin family and has been shown to be as important as the increased positive net charge. This points to a new direction for the design of potential chemotherapeutic agents.
Iron‐Mediated Desulphurization Towards the Synthesis of 2‐Halo Aromatic Isothiocyanates
Authors: Pinapati Srinivasarao , Mandapati Usharani , Rudraraju Ramesh Raju
Published: January 2017

A highly efficient and simple protocol for the construction of 2‐haloaromatic isothiocyanates from their respective amines in the presence of cheap, readily available and air stable iron catalyst is described. All the reactions were carried out under moderate reaction conditions could give their target products in good to excellent yields in shorter reaction time
Self‐Neutralizing Carbonic Acidic Catalyzed Synthesis of Benzothiazole Derivatives from Disulfides and Aldehydes in Water
Authors: Liu Bo , Zhu Ning , Cui ZhengQing , Liu Lei , Hong Hailong , Han Limin
Published: January 2017

An environmental friendly method was developed for preparing benzothiazole derivatives via the reaction of ortho‐anilino disulfides with aldehydes promoted by Na2S⋅9H2O in a reversible CO2‐H2O system without any other acid additive or organic solvent. Thus, this reaction system greatly simplifies post‐processing and allows for disposal without waste. The highly selective protocol affords the corresponding benzothiazoles from the reaction of disulfides and aldehydes with electron‐donating or withdrawing groups in good yields. Moreover, the dynamic equilibrium relationship between Na2S and the CO2 pressure had been explored by 13CNMR in high‐pressure NMR tube, which firstly demonstrated the carbonic acid was converted into CO32− or HCO3− promoted by Na2S in low or high CO2 pressure. Furthermore, the mechanism of Schiff base formation catalyzed by acid was confirmed by 1HNMR, and the process of benzothiazole formation from disulfide mediated by Na2S in CO2‐H2O system was also proposed.
Greener Friedel‐Crafts Acylation Using Microwave‐Enhanced Reactivity of Bismuth Triflate in the Friedel‐Crafts Benzoylation of Aromatic Compounds with Benzoic Anhydride
Authors: Tran Phuong Hoang , Nguyen Hai Truong , Hansen Poul Erik , Le Thach Ngoc
Published: January 2017

An efficient and facile bismuth trifluoromethanesulfonate‐catalyzed benzoylation of aromatic compounds using benzoic anhydride under solvent‐free microwave irradiation has been developed. The microwave‐assisted Friedel‐Crafts benzoylation results in good yields within short reaction times. Bismuth triflate is easily recovered and reused for several times without significant loss of catalytic activity.
An Unprecedented Synthesis of N‐Phenyl Amides via Cleavage of Benzotriazole Ring under Free Radical Condition
Authors: Singh Anoop S. , Kumar Dhananjay , Mishra Nidhi , Tiwari Vinod K.
Published: January 2017

An attempt of Bu3SnH mediated cyclization of acylbenzotriazoles (RCOBt) to corresponding benzoxazole failed; instead, corresponding N‐phenylamides were achieved in good yield. The reactions proceed via reductive cleavage of benzotriazole ring with consequent evolution of molecular nitrogen (N2). A diverse range of amide has been achieved in high yields. Structures of all the compounds have been elucidated using IR, MS, 1H and 13C NMR, while four of them (3 o, 3 w, 4 and 5) have also been characterized by single crystal X‐ray analysis.
Delivery of small‐for‐gestational‐age neonate and association with early‐onset impaired maternal endothelial function
Authors: Hillman S. L. , Kubba T. , Williams D. J.
Published: January 2017

Objective

Women who have delivered a small‐for‐gestational‐age (SGA) infant are at an increased risk of developing cardiovascular disease (CVD) in later life. Endothelial dysfunction is a subclinical sign of early CVD. It is unknown whether women who have recently had a pregnancy complicated by SGA, in the absence of other maternal and fetal diseases, have subclinical endothelial dysfunction. Our aim was to assess maternal endothelial function 6 months after a pregnancy complicated by SGA.

Methods

This was a case–control study conducted in a tertiary referral hospital in London, UK, over a 15‐month period. Flow‐mediated dilatation (FMD) of the brachial artery was measured in women 6.9 ± 2.5 months after childbirth. Forty‐four women were included in the study, of whom 15 had a SGA neonate (mean ± SD customized birth centile of 1.9 ± 2.3) and 29 delivered an appropriately grown baby (mean ± SD customized birth centile of 47.5 ± 26.3). The primary continuous variable, FMD, was assessed in each group and compared using unpaired t‐test.

Results

Women who had a SGA neonate had lower postpartum FMD (6.79 ± 0.95%) than did those who had an appropriately grown offspring (10.26 ± 2.44% (95% CI for difference between groups, −5.37 to −1.57); P = 0.0007). There were no differences in postnatal maternal blood pressure, abdominal circumference, weight and glucose, insulin and lipid profiles between the two groups.

Conclusions

Women who had a pregnancy affected by SGA, probably due to placental failure in the absence of pre‐eclampsia, have evidence of subclinical endothelial dysfunction within 6 months of childbirth. These women may benefit from lifestyle measures focused on the primary prevention of CVD. Further research in larger populations is needed to ascertain if such postpartum maternal endothelial dysfunction is a pregnancy‐induced phenomenon or if it is related to the pre‐existing maternal phenotype, and whether it persists long term. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.
Re: Lung and cardiac ultrasound for hemodynamic monitoring of patients with severe pre‐eclampsia. J. Ambrozic, G. Brzan Simenc, K. Prokselj, N. Tulz, M. Cvijic and M. Lucovnik. Ultrasound Obstet Gynecol 2017; 49: 104–109.
Authors: Zieleskiewicz L. , Leone M.
Published: January 2017

Linked Comment: Ultrasound Obstet Gynecol 2017; 49: 104–109
Incorporation of Sulfate or Selenate Groups into Oxotellurates(IV): I. Calcium, Cadmium, and Strontium Compounds
Authors: Weil Matthias , Shirkhanlou Mahdi
Published: January 2017

Seven new mixed oxochalcogenate compounds in the systems MII/XVI/TeIV/O/(H), (MII = Ca, Cd, Sr; XVI = S, Se) were obtained under hydrothermal conditions (210 °C, one week). Crystal structure determinations based on single‐crystal X‐ray diffraction data revealed the compositions Ca3(SeO4)(TeO3)2, Ca3(SeO4)(Te3O8), Cd3(SeO4)(Te3O8), Cd3(H2O)(SO4)(Te3O8), Cd4(SO4)(TeO3)3, Cd5(SO4)2(TeO3)2(OH)2, and Sr3(H2O)2(SeO4)(TeO3)2 for these phases. Peculiar features of the crystal structures of Ca3(SeO4)(TeO3)2, Ca3(SeO4)(Te3O8), Cd3(SeO4)(Te3O8), Cd3(H2O)(SO4)(Te3O8), and Sr3(H2O)2(SeO4)(TeO3)2 are metal‐oxotellurate(IV) layers connected by bridging XO4 tetrahedra and/or by hydrogen‐bonding interactions involving hydroxyl or water groups, whereas Cd4(SO4)(TeO3)3 and Cd5(SO4)2(TeO3)2(OH)2 crystallize as framework structures. Common to all crystal structures is the stereoactivity of the TeIV electron lone pair for each oxotellurate(IV) unit, pointing either into the inter‐layer space, or into channels and cavities in the crystal structures.
Sealing with Cyanoacrylate and a Falciform Patch Cannot Prevent Postoperative Pancreatic Fistula
Authors: Tillmann Laura‐Christin , Herzog Torsten , Uhl Waldemar , Belyaev Orlin
Published: January 2017

Background

This study aimed to evaluate the effect of a new combined method of covering the pancreatic anastomosis or stump with a cyanoacrylate and a falciform patch (CAFP) on the occurrence of postoperative pancreatic fistula (POPF).

Methods

Patients undergoing a pancreaticoduodenectomy (PD) or a distal pancreatectomy (DP) were recruited over a period of 12 months. The pancreaticojejunostomy in PD and the stump in DP were sealed with cyanoacrylate glue and wrapped in a falciform patch. Incidence and severity of POPF and associated postoperative complications were retrospectively compared with historical controls of 750 PD and 336 DP at the same institution and with current data from the literature.

Results

The new method was applied in 27 PD and 25 DP. The rate of clinically relevant POPF after PD with CAFP was 22.2% compared to 14.4% in historical patients, p = 0.26. The rate of clinically relevant POPF after DP with CAFP was 36% compared to 30% in historical patients, p = 0.65.

Conclusion

Sealing the pancreatic anastomosis or stump with a combination of a cyanoacrylate glue and a falciform patch didn’t reduce the rate of POPF after major pancreatic resections.
Cancer Genetic Counselors’ Current Practices and Attitudes Related to the Use of Tumor Profiling
Authors: Goedde LeAnne Noelle , Stupiansky Nathan W. , Lah Melissa , Quaid Kimberly A. , Cohen Stephanie
Published: January 2017

Tumor profiling (TP) is primarily used to identify driver mutations within a tumor for treatment purposes, but it may also identify germline mutations. Current involvement of cancer genetic counselors (GCs) in the TP process is not clear. Members of the National Society of Genetic Counselors Cancer Special Interest Group were invited to participate in a confidential, web‐based survey to characterize current practices and attitudes related to the use of TP. Of 105 useable responses, 86.7% of GCs reported their institutions were using TP, although only 6.7% did this routinely. Although 63.7% reported personal involvement in the process, largely with result interpretation and follow‐up germline testing, 69.7% reported seeing fewer than 5 patients for this reason and 97.9% desired further education on this topic. Work and regional setting were not predictors of involvement with TP; however, GCs in the academic setting were less aware of who obtains consent (p = 0.001). GCs reported they were not often utilized as a resource regarding TP. Overall, GCs believed TP is beneficial in identifying hereditary cancer syndromes, although most reported finding a germline mutation in <10% of cases. This study provides a snapshot of current GC involvement with TP, and documents the desire by GCs for additional education on tumor profiling.
Understanding investigators’ attitudes through a results-based accountability framework within a single CTSA institution
Authors: Rothwell Erin , Matheson Trent
Published: January 2017

Purpose

The National Center for Advancing Translation Science (NCATS) is implementing a new strategic management plan called the results-based accountability framework. This framework is part of the common metrics initiative. For successful implementation and adoption of new management strategies, it is important to assess current stakeholders’ experiences and needs.

Methods

Interviews were conducted with principal investigators who are conducting research and supported by the Center for Clinical Translational Science at the University of Utah. Between July and August 2016, 15 interviews were completed and audio recorded. A qualitative content analysis was conducted on the transcripts.

Results

Results indicated the need to provide education about the continuum of clinical translational research; time constraints during pre-award; barriers to IRB submissions; difficulty balancing other responsibilities in academic health centers; and the need for shared study coordinator resources.

Conclusion

Implementing a new management philosophy requires an understanding key stakeholders attitudes and needs. The research identified ways to help engage investigators with centralized resources supported by NCATS and implementation of common metrics at this university.
Arthur Sidgwick'sGreek Prose Composition: Gender, Affect, and Sociability in the Late-Victorian University
Authors: Rutherford Emily
Published: January 2017

The diaries and other papers of the Oxford classics teacher Arthur Sidgwick (1840–1920) show how men like Sidgwick used ancient Greek to demarcate the boundaries of an elite male social, emotional, and educational sphere, and how that sphere became more porous at the turn of the twentieth century through processes such as university coeducation. Progressive dons like Sidgwick stood by women's equality in principle but were troubled by the potential loss of an exceptional environment of intense friendships forged within intellectually rigorous single-sex institutions. Several aspects of Sidgwick's life and his use of Greek exemplify these tensions: his marriage, his feelings about close male friends, his life as a college fellow, his work on behalf of the Oxford Association for the Education of Women, and his children's lives and careers. The article recovers a lost world in which Greek was an active conversational language, shows how the teaching of classics and the inclusion of women were intimately connected in late-nineteenth-century Oxford, and suggests some reasons why that world endured for a certain period of time but ultimately came to an end. It offers a new way of explaining late-nineteenth-century cultural changes surrounding gender by placing education and affect firmly at their center.
The impact of Zheng He's expeditions on Indian Ocean interactions
Authors: Sen Tansen
Published: January 2017

This article examines the consequences of the Ming maritime expeditions led by Admiral Zheng He (1371–1433) in the early fifteenth century on Indian Ocean diplomacy, trade, and cross-cultural interactions. The presence of the powerful Ming navy not only introduced an unprecedented militaristic aspect to the Indian Ocean region, but also led to the emergence of state-directed commercial activity in the maritime world that extended from Ming China to the Swahili coast of Africa. Additionally, these expeditions stimulated the movement of people and animals across the oceanic space and might eventually have facilitated the rapid entry of European commercial enterprises into the Indian Ocean region during the second half of the fifteenth century.