bluuebunny/crossref_metadata_2025 huggingface dataset:
Covalent Warheads Targeting Cysteine Residue: The Promising Approach in Drug Development
Authors: Huang Fangjiao , Han Xiaoli , Xiao Xiaohui , Zhou Jinming
Published: November 2022

Cysteine is one of the least abundant amino acids in proteins of many organisms, which plays a crucial role in catalysis, signal transduction, and redox regulation of gene expression. The thiol group of cysteine possesses the ability to perform nucleophilic and redox-active functions that are not feasible for other natural amino acids. Cysteine is the most common covalent amino acid residue and has been shown to react with a variety of warheads, especially Michael receptors. These unique properties have led to widespread interest in this nucleophile, leading to the development of a variety of cysteine-targeting warheads with different chemical compositions. Herein, we summarized the various covalent warheads targeting cysteine residue and their application in drug development.
Emulsifying Properties of Rhamnolipids and Their In Vitro Antifungal Activity against Plant Pathogenic Fungi
Authors: Li Dongmei , Tao Weiyi , Yu Dinghua , Li Shuang
Published: November 2022

Rhamnolipids have significant emulsifying activity and the potential to become a component of pesticide emulsifier. Rhamnolipids are usually composed of two main components: mono-rhamnolipids (Rha-C10-C10) and di-rhamnolipids (Rha2-C10-C10). The proportion of di-rhamnolipids in the products ranged between 15% and 90%, affected by the production strains and fermentation process. In this paper, three kinds of rhamnolipid products containing di-rhamnolipids proportions, of 25.45, 46.46 and 89.52%, were used to test their emulsifying ability toward three conventional solvents used in pesticide (S-200, xylene, cyclohexanone) and antifungal activities against five strains of plant pathogenic fungi (Phytophthora capsici, Phytophthora parasitica var.nicotianae, Colletotrichum destructivum, Colletotrichum sublineolum, Fusarium oxysporum). The results indicated that although the CMC of the three rhamnolipids were significantly different, their emulsification properties had no remarkable differences, at a concentration of 10 g/L. However, their antifungal activities were significantly different: the more di-rhamnolipids, the stronger the antifungal activity. This work helps to promote the application of rhamnolipids as pesticides adjuvants.
The Effects of Pepper (Zanthoxylum bungeanum) from Different Production Areas on the Volatile Flavor Compounds of Fried Pepper Oils Based on HS-SPME–GC–MS and Multivariate Statistical Method
Authors: Niu Wenjing , Tian Honglei , Zhan Ping
Published: November 2022

Fried pepper oil retains the overall flavor outline of pepper, and its unique rich and spicy flavor is deeply loved by consumers. In order to study the effect of different production areas of pepper on the flavor compounds of fried pepper oil, taking dried pepper from seven different production areas as raw materials, and taking rapeseed oil as a carrier oil as well as a constant frying temperature to prepare pepper oil, the present study analyzed the volatile flavor components of pepper oil qualitatively and quantitatively by employing headspace solid phase microextraction (HS-SPME) and gas chromatography–mass spectrometry (GC–MS). The principal component analysis (PCA) method was used to construct the correlation analysis model of volatile flavor substances among different samples of pepper oil. Applying the hierarchical cluster analysis (HCA), the main volatile substances causing the flavor differences of pepper oil from different production areas were identified. The results showed that a total of 81 chemical components were identified, including 15 alcohols, 10 aldehydes, 5 ketones, 34 hydrocarbons, 11 esters, 6 acids, and others. Terpinen-4-ol, linalool, 2,4-decadienal, trans-2-heptenal, sabinene, linalyl acetate, bornyl acetate, myrcene, 1-caryophyllene, trans-α-ocimene, and limonene were selected as the main substances leading to the flavor differences among the pepper oil samples. These 11 chemical components played a decisive role in the construction of the overall aroma of the pepper oil. Using a descriptive sensory analysis, it was concluded that pepper oil from different production areas holds different aroma intensities. Compared with the other six samples, S4 Hanyuan Pepper Oil (HYPO) shows a relatively strong trend toward a spicy fragrance, fresh grassy fragrance, floral and fruity fragrance, fresh sweet fragrance, and fatty aroma.
The Determinants of Helpful Hotel Reviews: A Social Influence Perspective
Authors: Son Yukyung , Kang Kyungmo , Choi Ilyoung , Kim Jaekyeong
Published: November 2022

Online hotel reviews regarding specific experiences and the sensibility of hotel reviewers are important sources of information for consumers who want to book hotels in the future. However, since thousands of reviews are written for one hotel, it is practically impossible for customers to read all the reviews. To alleviate this problem, OTAs (online travel agencies) provide a helpful vote of reviews, helping customers to quickly find helpful reviews without much effort. Therefore, in this study, a ZINB (zero-inflated negative binomial regression) was performed to investigate factors that influence the helpfulness of hotel reviews using the social influence theory. As a result of the analysis, it was found that location, service, and value of the hotel, alongside normative influencing factors and the length of the review (including informational influencing factors), affect the helpfulness of the review regardless of the city. The results of this study are expected to help hotel managers to take remedial action on negative reviews and strengthen the promotion of positive reviews, potentially helping to increase customer satisfaction.
Exploring Potential Antimalarial Candidate from Medicinal Plants of Kheaw Hom Remedy
Authors: Chaniad Prapaporn , Techarang Tachpon , Phuwajaroanpong Arisara , Horata Natharinee , Septama Abdi Wira , Punsawad Chuchard
Published: November 2022

The Kheaw Hom remedy is a traditional Thai medicine widely used to treat fevers. Some plant ingredients in this remedy have been investigated for their antimicrobial, antiviral, anti-inflammatory, and antioxidant activities. However, there have been no reports on the antimalarial activities of the medicinal plants in this remedy. Therefore, this study focuses on identifying potential antimalarial drug candidates from the medicinal plant ingredients of the Kheaw Hom remedy. Eighteen plants from the Kheaw Hom remedy were extracted using distilled water and ethanol. All extracts were investigated for their in vitro antimalarial activity and cytotoxicity. An extract that exhibited good in vitro antimalarial activity and low toxicity was selected for further investigation by using Peter’s 4-day suppressive test and an acute oral toxicity evaluation in mice. Based on the in vitro antimalarial activity and cytotoxicity studies, the ethanolic extract of Globba malaccensis rhizomes showed promising antimalarial activity against the Plasmodium falciparum K1 strain (IC50 = 1.50 µg/mL) with less toxicity to Vero cells (CC50 of >80 µg/mL). This extract exhibited a significant dose-dependent reduction in parasitemia in P. berghei-infected mice. The maximum suppressive effect of this extract (60.53%) was observed at the highest dose administered (600 mg/kg). In a single-dose acute toxicity test, the animals treated at 2000 mg/kg died within 48 h after extract administration. In conclusion, our study indicates that the ethanolic extract of G. malaccensis rhizomes exhibited in vitro and in vivo antimalarial activities, which could serve as a promising starting point for antimalarial drug.
Regional Electric Vehicle Fast Charging Network Design Using Common Public Data
Authors: Pearre Nathaniel S. , Swan Lukas G. , Burbidge Erin , Balloch Sarah , Horrocks Logan , Piper Brendan , Anctil Julia
Published: November 2022

Electric vehicles rely on public fast charging when traveling outside a single charge range. Networks of fast charging hubs are a preferred solution, but should be deployed according to a design that avoids both redundant infrastructure representing overinvestment, and “charging deserts” which limit travel by EVs and thus inhibit EV adoption. We present a two-stage design strategy for a network of charging hubs relying on common public data including maps of roadways and electrical systems, and ubiquitous and readily accessible daily traffic volume data. First, the network design is based on the electrical distribution system, roadways, and a target inter-hub driving distance. Second, the number of fast chargers necessary at each hub to support expected vehicle kilometers is determined such that queuing to charge is infrequent. A case study to prepare Nova Scotia, Canada for the 2030 electric fleet of 15% of vehicles results in a network design with an average hub catchment area of 1230 km2 and 354 electric vehicles per fast charger, and ensures that they are equitably distributed and can enable travel by EV throughout the jurisdiction.
RESEARCH OF YOUTH VALUES FOR MARRIAGE AND FAMILY LIFE
Authors: DENYSOVETS T. , DENYSOVETS I. , PYVOVAR N. , KVAK O.
Published: November 2022

The article analyzes the relevance and importance of developing a high level of culture of marital and family relationships and the role of the family in the life of the individual. It was emphasized that in Ukraine for a long time many problems related to gender and sexual relations were not covered: the priority of class values over universal ones pushed out of the educational process educational work aimed at acquiring knowledge, skills and abilities that would guide them. becoming a man or a woman.The types of marital and family relations in modern youth and the attitude of high school students to marriage and cohabitation are determined. It is substantiated that, in particular, this type of relationship, such as cohabitation before marriage, in modern young people is based on the desire to know more meaningfully and in detail in extramarital life, of course, if this type of relationship is conscious and thoughtful. It was found that, despite the mostly positive attitude of high school students to marriage, family, family relationships, it is necessary to work more actively on educating students in marriage and family. The data on the views of modern youth, especially young people who are serious and balanced in the issue of marriage, choosing a marriage partner and providing for the family, have been thoroughly processed. The role of the family in maintaining and strengthening the physical, moral and spiritual health of young people, the formation of intersex relations and socialization of the child. It is generalized that the family has traditionally been, is and remains the first social environment for a child and one of the main centers of reproduction of human civilization, a separate nation.The age limits of marriage are identified on the basis of awareness of all the positive and negative aspects of this issue to make the right decision. It has been observed that modern young men and women carefully analyze the key factors in the processof marriage and choosing a marriage partner. Generalized knowledge about family, family life, marital responsibilities and parenting. It is highlighted that parents strive to raise their sons and daughters as real citizens, to instill in them the high moral qualities of the future family man, to form in young men and women a conscious attitude to their own health.
CHANGING THE LEVEL OF GENERAL AND SPECIAL PHYSICAL PREPAREDNESS OF CHERLIDERS IN THE PRE- COMPETITION PERIOD
Authors: SYNYTSYA S. , SYNYTSYA T. , SHESTEROVA L.
Published: November 2022

Cheerleading is a relatively new sport that has its own classification, is actively developing and has a large number of fans. Therefore, the issues of sports training of athletes are relevant, especially in the pre-competition period. Athletes from the cheerleading department of the specialized training group of the first year of study took part in the study. The study lasted for 6 months and covered two pre-competition periods: the Cup and the Cheerleading Championship of Ukraine.In the process of research, athletes performed general development exercises, as well as specially directed exercises to develop the necessary physical qualities. Technical characteristics such as flexibility, jumping, coordination, strength, endurance are important for the preparation of a cheerleader. Testing of general and special physical fitness was conducted twice. The first stage was held after three months of training in the pre-competition period for the Cup of Ukraine, the second - after six months of training before the Championship of Ukraine in cheerleading. A twine test was used to test and evaluate flexibility. To determine the strength endurance used the test of flexion and extension of the arms in a emphasis lying down. Flamingos were used to test coordination skills. To determine the level of special physical fitness of the cheerleader, we tested cher-jumps, lip-jumps and turns. The obtained results showed that the standards used were improved in the athletes of the study group. Studies of assessing the level of general and special physical fitness of cheerleaders of the group of specialized training in the pre-competition periods showed the following results: increased the number of athletes with a high level of general and special physical fitness from 63 % to 70 %; the number of above-average athletes decreased from 25 % to 22 %; the average level of general and special physical fitness also decreased from 10 % to 8 %. The level of general and special physical fitness is below average in the pre-competition period after 6 months of training was not recorded. Thus, the study showed positive changes in the standards of general and special physical fitness in the pre-competition period.
INNOVATIVE TECHNOLOGIES IN PREPARATION FUTURE SPECIALISTS FOR PROFESSIONALLY ORIENTED FOREIGN LANGUAGE COMMUNICATION
Authors: SEMENOVSKA L.
Published: November 2022

Based on analysis of the fundamental pedagogical, philological, philosophical, psychological works (A. Vitsyuk, O. Kovalenko, Y. Lavrysh, R. Lozanov, O. Osova, Y. Passov, etc.) the theoretical and methodological principles of using innovative technologies for training future specialists for professionally oriented foreign language communication are substantiated. The author describes the main approaches, principles and didactic possibilities of technological innovations in the training future specialists’ field for professionally oriented foreign language communication.The study found that future specialists` preparation for professionally oriented foreign language communication with the use of innovative pedagogical technologies has a fundamental and interdisciplinary nature; іt is studied by a wide range of scientific research areas. At the same time, it should be noted that the methodological and didactic aspects of the problem need further improvement. It was found that the preparation of future specialists for professionally oriented foreign language communication is a holistic, dynamic process of subject-subject interaction aimed at forming students’ readiness to use technological innovations in future professional activities that integrate learning, language and innovation competencies. Technological innovations in the field of training future specialists for professionally oriented foreign language communication are treated as a set of new methods, techniques, tools, forms of education, specially organized and aimed at implementing an innovative pedagogical process that provides foreign language communicative competence. As a result of studying the problem, the peculiarities of the use of innovative technologies of training future specialists for professionally oriented foreign language communication were revealed. This is reflected in the shift of emphasis: the teacher performs the mission of moderator, coach, tutor, facilitator in the learning process. A characteristic feature of the implementation of innovative technologies for training future specialists for professionally oriented foreign language communication in higher education institutions is their orientation towards the implementation of subject-subject educational activities of teachers and students, intensification of foreign language activities based on cooperation and co-creation strategies.
FOSTERING THE CAREER BUILDING COMPETENCE IN STUDENT TEACHERS OF HANDICRAFTS AND TECHNOLOGY: SCIENTIFIC AND EXPERIMENTAL APPROACH
Authors: OLEFIRENKO T.
Published: November 2022

The study reveals the essential features of the concept of «fostering the career building competence in student teachers of Handicrafts and Technology» as a dynamic combination of knowledge, skills, thinking, views, values and other personal qualities that determine the ability of the student teachers of Handicrafts and Technology to set career goals, plan the career, awareness of their own career potential and, accordingly, to effectively build a career path, successfully overcoming career problems. The above is based on the examination of the approaches of scientists to the definition of key research concepts. Having used the scientific and experimental approach, the study determined and characterised the structure of the career building competence in student teachers of Handicrafts and Technology as the set of the components such as motivational, cognitive, activity, reflective. Accordingly, the study specified the criteria, indicators and levels - initial, low, medium, high - of the formation of the phenomenon under study. It also provided the characteristics of the development levels. Precisely, the indicators of the motivational criterion were as follows: 1) positive attitude to career building; 2) the desire for self-expression and self-realization in professional activities; 3) having the values aimed at developing the necessary competencies for a career in education. The cognitive criterion was characterized as having and constant updating of knowledge: 1) on the field of education, objects and types of the selected professional activity, 2) about the possible ways of career development, 3) on forecasting, career planning in the education system. The activity criterion was defined as a set of skills and abilities: 1) to get engaged in the professional activities at the stage of education; 2) rapidly adapt to professional activity in the dynamics of external conditions; 3) to gain experience in career growth. The reflexive criterion was interpreted as the ability to: 1) analyse the job market requirements for teachers of Handicrafts and Technology from the professional environment perspective; 2) assess opportunities for professional and career growth; 3) reflect on the ways to overcome career crises and solve careerproblems.
TERMINOLOGICAL CHARACTERISTICS OF THE PROCESS OF FORMATION OF MANAGERIAL COMPETENCE OF THE FUTURE EDUCATION MANAGER
Authors: SVIERTNIEV O. , SHOSTAK Ye.
Published: November 2022

The article considers the theoretical foundations of the formation of managerial competence of the future education manager in a market economy. The terminological characteristics of the process of formation of managerial competence are carried out and the system of organizational and managerial skills of the education manager is theoretically substantiated. A systematic analysis of the literature on the research topic was revealed, the modern meanings of the concepts «competence», «professional competence», «management», «educational management» and «education manager» were revealed. The essence and content of the concept of «managerial competence» as a systemic phenomenon from different scientific positions are revealed.The content of the concept of «professional competence of the education manager» as a willingness to perform managerial (administrative) activities at a relatively high level, using sustainable professional qualities and experience. Identified and analyzed the key components of organizational and managerial activities of the future manager of education, which is the basis for the formation of his professional competence: organizational and managerial, technological, design and research.
Evaluación del efecto de concentración en una bebida funcional a partir de tuna blanca (Opuntia ficus) y aguaymanto (Physalis peruviana)
Authors: Ticsihua Huaman Jovencio , Orejon Montalvo Tania Yesenia
Published: November 2022

El estudio permitió obtener una bebida funcional a base de tuna blanca (Opuntia ficus) y aguaymanto (Physalis peruviana), formulada en 3 tratamientos, debido a que estos dos productos naturales tienen un alto valor biológico, que ayuda disminuir el riesgo de las enfermedades cardiovasculares en los individuos. El objetivo fue evaluar las concentraciones, propiedades fisicoquímicas y microbiológicas. Para la evaluación sensorial, utilizó escala hedónica del 1 al 5. La aceptabilidad se evaluó con 30 panelistas no entrenados, quienes avaluaron con mayor puntaje para el tratamiento 2, que se realizó con concentraciones de 50% de agua, 25% de tuna blanca y 25% de aguaymanto; la preparación de la bebida funcional se realizó en la Escuela Profesional de Ingeniería Agroindustrial de la Universidad Nacional de Huancavelica. Los resultados de análisis fisicoquímicos están dentro de los parámetros en la NTP 203.110 bebidas, jugos, néctares de frutos, el resultado de la capacidad de antioxidante presenta 783,52µ mol de trolox por 100 ml de muestra, compuestos fenólicos totales 254,15 mg ácido gálico por 100 ml, vitamina C 20,25 mg/100g, acidez 0,58 g /100ml, pH 6.1, solidos solubles 12,50 °Brix, fibra cruda 1.8 g/100 ml, proteína 4,65 g/100 ml y cenizas 1.70 g/100 ml. En la determinación microbiológica presenta los resultados en Aerobios Mesófilos 8,2x10, mohos <10, levaduras <10 Coliformes <3 estimado, los análisis fisicoquímicos y microbiológicos se realizó en Laboratorio de Certificadora Nacional de Alimentos SAC. Según los resultados obtenidos, se trata de una bebida nutritiva y adecuado para el uso humano.
Pesticidas organoclorados residuales en leche cruda procedente de la provincia El Oro, Ecuador
Authors: López Pinta Wilmer Andrés , Silverio Calderón Carmen Elizabeth
Published: November 2022

Para el control de las plagas en agricultura y ganadería se han utilizado herbicidas y pesticidas, en diferentes países de América y Europa está prohibido el uso de pesticidas organoclorados por el riesgo que representan para la salud de la vida animal y el ambiente. Sin embargo, a pesar de las restricciones estas sustancias permanecen en la cadena alimenticia porque se acumulan en el tejido graso, al ser insolubles en agua. El objetivo de este estudio fue analizar muestras de leche cruda, provenientes de tres ganaderías ubicadas en dos pisos climáticos de la Provincia de El Oro en Ecuador, para detectar la presencia de pesticidas organoclorados residuales. La toma de seis muestras de leche cruda se realizó según la Norma Técnica Ecuatoriana NTE INEN-ISO 707. Para la preparación y análisis de las muestras se utilizó la versión Quechers y la Cromatografía de Gases acoplada a Espectrometría de Masa. En esta investigación se evaluaron residuos de: alfa BHC, beta BHC, delta BHC, gama BHC, Heptacloro, Aldrín, Heptacloro Epóxido, Alfa Clordano, Gama Clordano, alfa Endosulfán, beta Endosulfán, 4-4’ DDE, Dieldrín, Endrín, 4-4’ DDD, Endrín Aldehído, 4-4’ DDT, Endosulfán Sulfato, Metoxicloro y Endrín Ketona en muestras de leche cruda. Los resultados de los análisis realizados en el Laboratorio de Investigación en Toxicología en Salud de la Universidad Andina Simón Bolívar concluyeron que no hubo presencia de estos analitos. Se concluye que la leche de estas ganaderías puede ser comercializada y consumida por la población y que no representa riesgo en cuanto al contenido de pesticidas organoclorados.
Trabalho Docente e Ensino Remoto na Educação Básica no Brasil sob a Pandemia Covid-19
Authors: Previtali Fabiane , Fagiani Cílson César
Published: November 2022

El objetivo del artículo es problematizar la labor docente en la educación básica pública en Brasil, en particular en el estado de Minas Gerais, en el ámbito de la difusión de las tecnologías informáticas-digitales o Industria 4.0 y de las políticas neoliberales bajo los principios de la Nueva Gestión Pública. (NGP). El análisis recae en el perfil de los docentes, la calificación profesional y las condiciones laborales, con especial atención a la difusión del teletrabajo a distancia bajo la pandemia Covid-19. La metodología se basó en estudios bibliográficos, documentales, informes de investigación y análisis de datos del Instituto Brasileño de Geografía y Estadística (IBGE), Instituto Nacional de Estudios e Investigaciones Educativas “Anísio Teixeira” (INEP), en períodos seleccionados. Los resultados indican la inseparabilidad entre capitalismo neoliberal, NGP y tecnologías digitales, lo que implica la profundización de la ya precaria carrera del profesional docente em Brasil.
En relación con los sujetos en investigación biográfica en educación
Authors: Dizerbo Anne
Published: November 2022

Esta contribución se propone interrogar la relación del investigador con los actores-sujetos de la investigación, en lo relativo a las especificidades de la investigación biográfica en educación y los efectos de los dispositivos que pone en funcionamiento. Para esto se apoyará en una investigación llevada a cabo junto a diversos grupos de estudiantes secundarios, a partir de entrevistas biográficas colectivas e individuales y de relatos escritos sobre sus recorridos escolares. Esta investigación tuvo dos finalidades: comprender los modos de subjetivación de dichos recorridos escolares y de orientación, y transformar una situación en la que los alumnos tenían dificultades para apropiarse de ese recorrido de orientación y cooperar. Se presentará el dispositivo puesto en práctica y su marco epistemológico y metodológico luego de analizar sus efectos para comprender las encrucijadas de la relación del investigador con los actores-sujetos en investigación biográfica. Se pondrá en evidencia que las especificidades de este campo de investigación invitan, por una parte, a inscribir la investigación en un espacio de encuentro simétrico, espacio de autorización, propicio al desarrollo del poder de actuar de los actores y, por otra, a desarrollar una postura empática garante del respeto de los actores y de su proceso de autonomía.
A universidade privada na perspectiva de (ex) universitários que participam de coletivos
Authors: Monfredini Ivanise , Alves de Souza Ferreira Denise
Published: November 2022

Qual pode ser a contribuição da universidade privada na formação política de universitários que participam de coletivos? No artigo as autoras analisam depoimentos de ativistas sociais, que foram obtidos durante a realização de pesquisa de mestrado mais ampla, entre os anos de 2017 e 2018. Os depoimentos sugerem que a universidade contribuiu para a formação política, especialmente quanto aos conhecimentos que nelas circulam. No entanto, as relações pautam-se pelo autoritarismo e individualismo, limitando uma formação política plena. A metodologia que fundamenta o estudo é de tipo qualitativo, cujo levantamento de informações se deu por análise de bibliografia sobre o tema e de depoimentos obtidos por meio de entrevista semi estruturada realizada com treze universitários e ex-universitários que fizeram seus cursos de graduação em universidades com sede na Região Metropolitana da Baixada Santista. Num cenário de ataque à democracia, as autoras consideraram relevante retomar esses depoimentos, pois eles permitem uma reflexão sobre o processo de formação política apartado de vivências democráticas. Diante dos processos restritivos à política, à educação, à ciência, ao conhecimento, as autoras trazem para o debate a perspectiva desses universitários e ex-universitários, visando contribuir com o debate e a defesa da universidade como direito de todos
Diverticulo de Kommerell
Authors: Umaña Alice Vanessa , Garcia Quirós Christian , Garnier Portela Michelle
Published: November 2022

Masculino de 68 años, desconocido enfermo, tabaquista activo, quien presenta historia de disnea de larga data asociado dolor precordial, por lo que se realizó tamizaje por cáncer pulmonar, encontrándose como hallazgo incidental un diverticulo de Kommerell asociado a probable anillo vascular aórtico.
Vaginosis bacteriana, una enfermedad que se rebela a los postulados de Koch y, el rol del microbioma vaginal en su desarrollo
Authors: Uribe Calvo María José , Sanchez Acevedo Melanny , Calderon Ureña Evelyn , Villalobos Abarca Sofía , Morales Rodriguez Yosseline
Published: November 2022

Las vaginosis bacterianas son infecciones que afectan a un 30% de las mujeres en edad reproductiva. Es una enfermedad común, pero poco entendida, que muchas veces es tratada sin tener claridad de su causa. Las vaginosis, son procesos causados por disbiosis en la microbiota vaginal, que rompen el equilibrio en el ecosistema, generando inflamación y desplazamiento de los lactobacilos. Diferentes factores de riesgo y determinantes ambientales o del individuo, promueven la disbiosis vaginal. Aunque se han asociado ciertos microorganismos, no se conoce un agente etiológico. Algunos estudios han tenido como objetivo, estudiar las diferentes variables que influyen en la disbiosis, y, análisis metagenómicos han determinado, que existen microorganismos no identificados, asociados a la enfermedad. Conocer cuáles son esos microorganismos, detectarlos en la población y cambiar nuestra mentalidad sobre la microbiota vaginal, podría afinar el diagnóstico de las vaginosis bacterianas. Se concluye que el conocimiento de la microbiota vaginal está en sus inicios, hay mucho que investigar y comprender. Esto debe ser un incentivo para que los profesionales se hagan preguntas, busquen respuestas y se generen nuevos tratamientos eficaces.
Interpretación del electrocardiograma normal
Authors: Watson Hernandez Rebeca Alina
Published: November 2022

El electrocardiograma (ECG) permite documentar la actividad eléctrica del corazón. Es una herramienta sumamente útil que funciona para complementar el diagnóstico de enfermedades cardiovasculares, control de tratamiento en caso de que se utilicen fármacos cardiotóxicos, alteraciones hidroelectrolíticas, etc. Consta de doce derivaciones que se registran en un papel milimetrado que debe estar con las características de velocidad y amplitud adecuadas para que no haya errores en la interpretación. Se recomienda tener un orden sistemático para la lectura de este, así no se pasarán detalles por alto. Previo a la confirmación de que sea el estudio del paciente indicado, se haba verificado el ritmo cardiaco, la frecuencia cardiaca y el eje eléctrico; se tiene de izquierda a derecha la onda P, el intervalo PR, el complejo QRS, el segmento ST y la onda T. Además, hay que recordar que en deportistas existen cambios esperables que se mantienen dentro de las características de un ECG normal tales como la frecuencia y otros cambios estructurales.
Impresión de medicamentos en 3D en población geriátrica: Una mirada al futuro
Authors: Zúiga Gámez Kassandra , Castañeda Pinto Paula , Castellanos Betancourth Libny , Cristofori da Silva María José , Durán Chavarría Katherine
Published: November 2022

El desarrollo de técnicas de impresión en 3D permite el avance de la medicina personalizada, la cual está fundamentada en diseñar tratamientos basados en la individualidad de los pacientes y sus comorbilidades específicas, con el fin de mejorar la adherencia y la seguridad en el manejo terapéutico. La importancia de esta tecnología radica en que permite diseñar las características de los tratamientos para así ofrecer una solución a los inconvenientes asociados con la polifarmacia en los pacientes geriátricos, mediante la disminución de la cantidad de fármacos que estos deben utilizar diariamente. Además, por medio de la combinación de varios compuestos activos en uno solo, se logra el aumento de la adherencia, la seguridad y la tolerabilidad al tratamiento en los pacientes. El objetivo de este manuscrito es indagar en la importancia del desarrollo de la impresión de medicamentos 3D y cómo esta técnica aumenta el apego a las terapias en la población geriátrica, así como también permite disminuir los riesgos asociados a la polifarmacia en este grupo demográfico. La impresión de medicamentos en 3D mejora la calidad de vida en la población geriátrica polimedicada, sin embargo actualmente no se cuenta con suficiente información al respecto, por lo cual se recalca la importancia de continuar con el desarrollo de investigaciones que permitan identificar las ventajas y limitantes de esta tecnología.
Evolución clínica de los pacientes receptores de trasplante cardíaco del hospital Dr. Rafael Ángel Calderón Guardia, Costa Rica 2007-2020
Authors: Mora María del Rosario , Saborío Morales Lachiner , Araya Fonseca Carlos , Dailey Marietta
Published: November 2022

Antecedente y objetivos: Hasta la realización de este estudio, se desconocía la evolución clínica de los pacientes receptores de trasplante cardiaco en Costa Rica. El objetivo de este trabajo fue documentar los resultados del Programa de Trasplante Cardíaco del Hospital Dr. Rafael Ángel Calderón Guardia desde el inicio de este programa en 2007 hasta 2020.

Métodos: Investigación observacional retrospectiva de 33 pacientes que recibieron trasplante de corazón.

Resultados: La miocardiopatía dilatada idiopática fue la indicación más frecuente de trasplante (27.3%). La mayoría de los pacientes receptores fueron hombres (63.6%). La mayoría de los receptores presentaban 5 (45.4%) ó 6 (27.2%) discordancias de HLA con el donador. El rechazo agudo celular 2R se presentó en 30% de los casos en los primeros 30 días. La sobrevida a 10 años fue de 14%.

Conclusiones: Aunque los hallazgos documentados en esta investigación fueron similares a los reportados en otros centros, el rechazo agudo significativo fue mayor al esperado y la sobrevida a largo plazo fue mucho menor.
Prevalence and pattern of refractive error in a tertiary health facility in southwest Nigeria
Authors: Otulana Taibat Olusola , Bodunde Olubunmi Temitope , Ajibode Haroon Adetunji , Onabolu Oluwatoni Olaide
Published: November 2022

Background: Globally, uncorrected refractive error (RE) is a major cause of blindness, visual impairment (VI), and low vision.

Aim: To determine the prevalence, pattern, and level of visual impairment among clinic patients with refractive error in a tertiary health facility.

Methods: This was an analytical cross-sectional study conducted on patients who presented at a tertiary health facility in Ogun State, Nigeria. The biodata of the patients, level of education, occupation, the symptoms, and signs including the visual acuity (at presentation and after correction), and diagnosis were considered. Lenses that gave the patient the best vision were recorded as the type and magnitude of refractive error for that individual.

Results: The prevalence of RE was 10.6%. Children and adolescents comprised 23.3% of the cases of refractive error while traders comprised 17.1%. Those who did not have formal education were 3.7%. Blurring of vision for near was the most common presenting symptom. Normal visual acuity (6/6) and better was 33.4% at entry and 77.4% with correction. Myopia was observed to be the most common type of RE in children and adolescents. The prevalence of VI and blindness was 6.7%.

Conclusion: RE is a major cause of blindness and VI, with the prevalence of myopia higher in age group thirty years and below: lack of formal education may be a barrier for uptake of refractive error services in population with low literacy level.
Pengaruh Penggunaan Abu Sekam Padi (Rice Husk Ash) Pada Beton Normal Terhadap Nilai Kuat Tekan
Authors: Santoso Teguh Haris
Published: November 2022

This study aims to determine the effect of adding rice husk ash to normal concrete on its compressive strength value. The benefit of this research is to increase knowledge about the effect of rice husk ash which can be used as an effort to reduce the use of Portland cement in concrete. This research method uses an experimental method of an experiment to determine the effect of a variable under study. The location of this research was conducted at the laboratory of PT. Nisajana Hasna Rizqy Tegal. The results of this study are the composition of the mixture of rice husk ash mixture which has the greatest compressive strength value occurs in the mixture of ASP * 10% concrete at 19.84 MPa aged 28 days, the compressive strength value does not reach the planned target of 24 MPa.  Keywords : Rice Husk Ash, Concrete, Compressive Strength Value
STUDI REDUKSI BANJIR DENGAN KOLAM RETENSI PADA SUNGAI-SUNGAI PARALEL
Authors: Yusuf Rakhmat
Published: November 2022

Flood in Ujungberung region occurs when rainy season. The location of the Ujungberung region is in the Bandung basin area from the upstream river originating at the Mount Manglayang. The impact of floods that occur is disrupting the drainage flow, settlement, traffic and economic land use such as markets, and agriculture in the region. The government has made some prevention efforts by constructing three Retention Basin on the Cinambo River, Cipamulihan River, and Cilameta River. There isn’t analysis on how much the optimal reduction in flood discharge and reservoir volume. In this study using a quantitative approach and descriptive method. Retanding basin analysis is based on the 25-years hydrological flood discharge using the Snyder method HEC-HMS v4.3 software. From the results of the Retention Basin modeling, it was found that in the Cinambo River with the initial discharge of  Q25 is 37.70 m3/sec become 11.10 m3/sec can be reduced by 70.56 % with an optimal storage volume of 143,300 m3, in the Cipamulihan River with the initial discharge of Q25 is 19.20 m3/sec become 8.10 m3/sec can be reduced by 57.81 % with an optimal storage volume of 143,300 m3, and in the Cilameta River with the initial discharge of Q25 is 13.40 m3/sec become 9.3 m3/sec can be reduced by 30.60% with an optimal storage volume of 23,100 m3. If the Retention Basin planned to be carried out with an optimal storage volume, it must be adjusted to the available retention land area and with a required dimension.
Studi Literatur Penggunaan Metode BIM Pada Software Autodesk Revit Structure
Authors: Chandra Nanang
Published: November 2022

Building Information Modeling (BIM) can be a useful platform for engineers in designing or modeling a building. Autodesk Revit is a BIM based architectural and structural design program. The purpose of this research is to deepen the Autodesk Revit Structure application program in terms of features, facilities provided by revit, the basis for working on the revit program, as well as detailed design steps for columns, beams and foundations. The method that will be used in this research is to collect data from several appropriate sources with the title of the study, the reference sources include books, the internet and reviews related to case studies conducted on this application. The results of this study explain the facilities needed to run the revit structure, such as buying a license and downloading the trial for students, the steps for modeling a project using autodesk revit, such as understanding the initial display of the autodex revit software, project browser,box properties, ribown menu, introducing the display initial (user interface), as well as modeling structure. The conclusion of this research is that soft drowing on autodex revit can be made in 3D, making it easier for engineers to design detailed parts and check for errors that occur. So that in certain cases if there is an error in the modeling, the engineers can correct the error without changing all parts, because with this revit application, if one part is changed, it appears that it will automatically change.
EVALUASI TAMPANG DRAINASE DESA KUTA PADANG KABUPATEN ACEH BARAT
Authors: Safriani Meylis , Suciatina Cut Silvia , Fachruddin Fachruddin
Published: November 2022

Drainase merupakan suatu sistem untuk mengalirkan air hujan. Sistem ini mempunyai peranan penting dalam menciptakan lingkungan yang baik dan sehat, apalagi di daerah berpendudukan padat seperti di perkotaan. Banjir genangan sering terjadi di Jalan Lueng Aneuk Aye Desa Kuta Padang Kota Meulaboh di setiap hujan turun dengan durasi hujan 1 jam. Evaluasi tampang drainase diperlukan untuk mengetahui kapasitas penampang drainase dan penyebab terjadinya banjir genangan. Debit banjir dianalisis dengan metode Rasional. Dari hasil analisa intensitas curah hujan rancangan dengan periode ulang 5 tahun didapat nilai 177,6 mm. Dari perhitungan kapasitas saluran drainase, terdapat 6 titik pias saluran drainase yang perlu diperlebar atau diperdalam agar tampang saluran drainase tidak terjadi luapan air hujan. Dari hasil survei di lapangan, terdapat 5 pias drainase yang diperlukan pembersihan sedimentasi agar air hujan tidak tersumbat.
ANALISIS DINAMIK PADA GEDUNG A1 PEMONDOKAN UPT. ASRAMA HAJI EMBARKASI ACEH DENGAN MENGGUNAKAN METODE TIME HISTORY
Authors: Azani Alif Akbar , Rahman Aulia , Hady Munirul , . Bunyamin
Published: November 2022

Indonesia is one of the countries most prone to earthquakes, causing a lot of damage to building structures. Therefore, buildings require earthquake resistance to allow time for building occupants to evacuate from the building. The object of this research is the A1 Hajj Boarding Boarding Building for the Embarkation of Aceh which is located on Teuku Nyak Arif Street, Kuta Alam District. The purpose of this study was to see whether the building met the requirements of SNI 1726-2019 in response to the Simeulue I earthquake with a magnitude of 8.3 on April 11, 2012, using Time History analysis with the help of software ETABS. By reviewing the building deformation, displacement and deviation between levels, knowing the working forces in the form of axial forces, bending moments, and shear forces on the columns and beams of the building. Data processing will be analyzed with the standard rules of SNI 1726-2019. From the analysis, it is found that the basic shear strength due to earthquake loads is 2302.1 kN for the x direction and 637.6 kN for the y direction. The largest maximum lateral displacement is 11.445 mm for the x-direction and 11.774 mm for the y-direction, causing the interstory drift of each combination of loading structures to remain within the limits permitted by earthquake-resistant building standards (SNI 1726:2019). It can be concluded that the Aceh Embarkation Hajj Dormitory Building A1 has been designed in accordance with the SNI 1726:2019 standard.
IMPLEMENTASI PASAL 24 NOMOR 7 TAHUN 2013 PERATURAN DAERAH KABUPATEN TULUNGAGUNG TENTANG PEMANFAATAN BAGIAN JALAN (Study Kasus Di Kampung Dalem)
Authors: FATIMAH AGUSTIN LAILATUL , ARIFIN ZAINAL , HASYM MOCHAMAD WAHID
Published: November 2022

Penelitian ini mengkaji tentang implementasi pasal 24 nomor 7 tahun 2013 mengenai peraturan daerah Kabupaten tulungagung tentang pemanfaatan bagian jalan. Penelitian ini menggunakan metode hukum empiris. Berdasarkan penelitin ini didapatkan bahwa bahwa tujuan serta sasaran yang ingin dicapai dalam menjalankan penertiban penggunaan jalan sudah hampir tercapai, hal tersebut dilakukan oleh Dinas perhubungan dengan cara melakukan penertiban pelanggaran yang telah ditunjukkan untuk para pedagang kaki lima dan parkir liar. Tindakan yang telah dilakukan sudah sesuai berdasarkan kebijakan yang telah diterapkan berdasarkan beberapa hal yang telah tertuang di dalam Peraturan Daerah Kabupaten Tulugagung No 7 tahun 2013, yang menyatakan bahwa Dinas Perhubungan membentuk suatu tim untuk melakukan suatu razia yang bertujuan untuk menertibkan para pelanggar.
Ryan Maulana HUKUMAN KEBIRI BAGI PELAKU KEKERASAN SEKSUAL TERHADAP ANAK (PEDOFILIA) BERDASARKAN UU PERLINDUNGAN ANAK
Authors: Maulana Ryan , Rochmani Rochmani
Published: November 2022

Tujuan penelitian ini adalah untuk menjelaskan:1) dasar pembentukan sanksi kebiri pada pelaku kekerasan seksual terhadap anak; dan 2) keberadaan sanksi kebiri dalam kebijakan hukum pidana. Penelitian ini termasuk dalam tipe penelitian hukum normatif/doktrinal, yaitu tipe penelitian menggunakan pendekatan undang-undang (statute approach), asas hukum dan doktrin-doktrin sebagai kajiannya. Objek penelitian ini ialah hukum yang dikonsepkan sebagai apa yang tertulis dalam peraturan perundang-undangan yang dibuat oleh lembaga yang berwenang, dalam bentuk Undang-Undang tentang perlindungan anak dari tindak pidana kekerasan seksual (pedofilia). Spesifikasi penelitian ini adalah deskriptif analitis yaitu untuk menggambarkan tentang hukuman kebiri bagi pelaku kekerasan seksual terhadap anak (pedofilia) berdasarkan Undang-Undang Perlindungan Anak. Hasill penelitianl memperlihatkanl bahwal 1)l hukuml  kebiril  kimial (chemicall castration)l terhadapl pelakul tindakl pidanal pedofilial  kepadal anak-anakl menurutl  hukuml pidanal  Indonesial sudahl mencakupl unsurl yangl terdapatl padal suatul  hukuman,l  yaitu:l sebagail upayal pembalasanl (reverenge)l atasl perbuatanl melanggarl  hukuml danl  ketentuanl  yangl sudahl dibuatl ataul ditetapkan.l Penetapanl Sanksil  kebiril  yangl diterapkanl dalaml Undang-Undangl Nomorl 17l Tahunl 2016l Tentangl Perlindunganl  Anakl bertujuanl untukl menjagal kemaslahatanl masyarakatl Indonesial daril pelakul pedofilial danl memberil efekl  jeral kepadal pelakul sertal bentukl pertanggungjawabanl  hukuml bagil pelakul tindakl pidanal pedofilia.l Pihakl kontral atasl pelaksanaanl sanksil kebiril  kimial umumnyal berargumentasil bahwal hall tersebutl bertentanganl denganl prinsip-prinsipl HAMl jugal berpotensil  konflikl denganl Kodel Etikl Profesil Kedokteran;l danl 2)l saatl  inil  kebiril telahl menjadil produkl undang-undangl  yangl baru,l tentunyal dalaml kebijakanl  hukuml pidanal dikenall denganl  kebijakanl denganl pembentukan,l  kebijakanl penegakan,l kebijakanl pelaksanaan.l sementaral penulisanl penelitianl  inil  hanyal terbatasl padal  kajianl  kebijakanl keberadaanl pembentukanl undang-undangl semata.

 

Kata kunci: hukuman kebiri, kekerasan seksual dan undang-undang Perlindungan Anak
Aulya Tri Susianawati OPTIMALISASI PERLINDUNGAN HUKUM KORBAN PERDAGANGAN ORANG (HUMAN TRAFFICKING) BERDASARKAN UNDANG-UNDANG NOMOR 21 TAHUN 2007 TENTANG PEMBERANTASAN TINDAK PIDANA PERDAGANGAN ORANG
Authors: Susianawati Aulya Tri , Faozi Safik
Published: November 2022

Fakta bahwa perlindungan hukum terhadap korban masih kurang, dikarenakan masih adanya hambatan dalam upaya perlindungan hukum bagi korban trafficking perlu adanya upaya-upaya yang konkrit agar lebih optimal memberikan perlindungan kepada korban trafficking. Tujuan penelitian ini untuk mengetahui bentuk perlindungan hukum bagi korban perdagangan orang dan upaya dalam mengoptimalkan perlindungan hukum korban perdagangan orang. Penelitian ini menggunakan penelitian hukum yuridis empiris. Sumber data yang digunakan oleh penulis adalah data primer dan data sekunder dengan menggunakan teknik pengumpulan data dilakukan melalui wawancara kepada pihak PPT Seruni dan Unit II Subdit IV Ditreskrimmum Polda Jateng guna mendapatkan informasi data yang lebih akurat serta melalui kepustakaan. Bentuk perlindungan hukum korban trafficking dalam hasil penelitian yang diberikan oleh pihak PPT Seruni meliputi 5 (lima) layanan dasar, yaitu : layanan pengaduan; pendampingan dan bantuan hukum; layanan medis; rehabilitasi; layanan reintegrasi sosial dan pemulangan. Sedangkan bentuk perlindungan hukum korban trafficking yang diberikan oleh Kepolisian berupa : pelaporan/pengaduan korban; diberitahukan bentuk perlindungan dan hak- hak korban; dalam kesaksiannya dapat didampingi advokat/pendamping lainnya; dirahasiakan identitas; proses penyelidikan dilakukan di RPK dan ditangani oleh penyidik khusu; menyediakan tempat perlindungan rumah aman/shelter. Untuk optimalnya perlindungan hukum korban sangat diperlukan meningkatkan komitmen lembaga/instansi; penyuluhan hukum dan sosialisasi dalam menyampaikan informasi terkait tindak pidana perdagangan orang di masyarakat; lebih melibatkan aparat penegak hukum dalam permohonan dan pengumpulan bukti penuntutan restitusi dan kompensasi; pemenuhan hak korban; menggabungkan permohonan restitusi dan kompensasi saat penyelidikan.

Kata Kunci : Optimalisasi, Perlindungan Hukum, Korban Perdagangan Orang