bluuebunny/crossref_metadata_2025 huggingface dataset:
Addition of Carbamoylsilanes to Electrophilically Substituted Alkenes. Preparation of β‐Functionalized Tertiary Amides.
Authors: Cunico Robert F. , Motta Adalie Rodriguez
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
High‐Intensity Ultrasound and Microwave, Alone or Combined, Promote Pd/C‐Catalyzed Aryl—Aryl Couplings.
Authors: Cravotto Giancarlo , Beggiato Marina , Penoni Andrea , Palmisano Giovanni , Tollari Stefano , Leveque Jean‐Marc , Bonrath Werner
Published: June 2005

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Selective Palladium‐Catalyzed Arylation(s) of Benzaldehyde Derivatives by N‐Heterocarbene Ligands.
Authors: Guerbuez Nevin , Oezdemir Ismail , Cetinkaya Bekir
Published: June 2005

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Tunable 1,3‐Lithium Shift of Propargylic/Allenylic Lithiums Formed by Conjugate Addition of 4‐Aryl‐3‐butyn‐1‐enes with Organolithiums and the Subsequent Transmetalation/Pd(0)‐Catalyzed Coupling Reaction with Aryl Halides.
Authors: Ma Shengming , He Qiwen , Jin Xin
Published: June 2005

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A Novel Silica‐Supported Palladium Catalyst for a Copper‐Free Sonogashira Coupling Reaction.
Authors: Tyrrell Elizabeth , Al‐Saardi Ali , Millet Julien
Published: June 2005

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Pseudo‐Geminally‐Substituted [2.2]Paracyclophanes as Spacers for Bisallenyl Sulfoxides and Sulfones.
Authors: Birsa M. Lucian , Jones Peter G. , Braverman Samuel , Hopf Henning
Published: June 2005

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Tandem Catalysis: A Ring‐Closing Metathesis Followed by Dehydrogenative Oxidation to Afford Substituted Indenones.
Authors: van Otterlo Willem A. L. , Coyanis E. Mabel , Panayides Jenny‐Lee , de Koning Charles B. , Fernandes Manuel A.
Published: June 2005

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The Synthesis, Structural Characterization and Photochemistry of Some 3‐Phenylindenones.
Authors: Seery Michael K. , Draper Sylvia M. , Kelly John M. , McCabe Thomas , McMurry T. Brian H.
Published: June 2005

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The Indium‐Mediated Selective Introduction of Allenyl and Propargyl Groups at the C4‐Position of 2‐Azetidinones and the AuCl3‐Catalyzed Cyclization of 4‐Allenyl‐2‐azetidinones.
Authors: Lee Phil Ho , Kim Heechul , Lee Kooyeon , Kim Misook , Noh Kwanghyun , Kim Hyunseok , Seomoon Dong
Published: June 2005

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Efficient Synthesis of Functionalized Furans and Benzofurans Based on a “[3 + 2] Cyclization/Oxidation” Strategy.
Authors: Bellur Esen , Freifeld Ilia , Langer Peter
Published: June 2005

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Novel Lactonization of Ethenetricarboxylate Derivatives: Intermolecular Trapping of Alkenes.
Authors: Yamazaki Shoko , Ohmitsu Kanae , Ohi Kunihiro , Otsubo Tetsuya , Moriyama Kayo
Published: June 2005

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A Novel One‐Pot Synthesis of Some New Interesting Pyrrole Derivatives.
Authors: Azizian Javad , Karimi Ali Reza , Kazemizadeh Zahra , Mohammadi Ali A. , Mohammadizadeh Mohammad R.
Published: June 2005

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A New Approach for the Synthesis of 2‐Substituted Indole Derivatives via Michael Type Adducts.
Authors: Cavdar Hueseyin , Saracoglu Nurullah
Published: June 2005

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Homotryptamines as Potent and Selective Serotonin Reuptake Inhibitors (SSRIs).
Authors: Schmitz William D. , Denhart Derek J. , Brenner Allison B. , Ditta Jonathan L. , Mattson Ronald J. , Mattson Gail K. , Molski Thaddeus F. , Macor John E.
Published: June 2005

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New Intra—Intermolecular Criss‐Cross Cycloaddition of Unsymmetrical Allenylazines with Alkynes Leading to Three Fused Five‐Membered Heterocycles.
Authors: Man Stanislav , Necas Marek , Bouillon Jean‐Philippe , Baillia Henri , Harakat Dominique , Potacek Milan
Published: June 2005

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A Mild and Efficient One‐Pot Synthesis of 2‐Dihydroimidazoles from Aldehydes.
Authors: Fujioka Hiromichi , Murai Kenichi , Ohba Yusuke , Hiramatsu Atsushi , Kita Yasuyuki
Published: June 2005

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Total Synthesis of LFA‐1 Antagonist BIRT‐377 via Organocatalytic Asymmetric Construction of a Quaternary Stereocenter.
Authors: Chowdari Naidu S. , Barbas Carlos F. III
Published: June 2005

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Synthesis and Properties of Sulfonamide Derivatives of 3,5‐Dimethylisoxazole.
Authors: Korsakov M. K. , Filimonov S. I. , Dorogov M. V.
Published: June 2005

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Synthesis of 2‐Aminoethyl‐5‐carbethoxythiazoles Utilizing a Michael‐Like Addition Strategy.
Authors: Boy Kenneth M. , Guernon Jason M.
Published: June 2005

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Novel and Potent NPY5 Receptor Antagonists Derived from Virtual Screening and Iterative Parallel Chemistry Design.
Authors: Guba Wolfgang , Neidhart Werner , Nettekoven Matthias
Published: June 2005

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ZrCl4‐Mediated Cross‐Cyclization Between Epoxides and Homoallylic Alcohols: Synthesis of 4‐Chlorotetrahydropyran Derivatives.
Authors: Yadav J. S. , Rajasekhar K. , Murty M. S. R.
Published: June 2005

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Synthesis of Thienothiopyranthiones by a New Molecular Rearrangement.
Authors: Ogurtsov Vladimir A. , Rakitin Oleg A. , Rees Charles W. , Smolentsev Alexey A. , Belyakov Pavel A. , Golovanov Denis G. , Lyssenko Konstantin A.
Published: June 2005

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Synthesis with Improved Yield and Study on the Analgesic Effect of 2‐Hydroxyphencyclidine.
Authors: Ahmadi Abbas , Shafiezadeh Mahshid , Fathollahi Yaghoob , Darvich Mohammad Raouf , Mahmoudi Ali , Bahmani Manouchehr , Rahmati Batol
Published: June 2005

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A Convenient One‐Pot Synthesis of 4‐, 6‐, and 7‐Azaindoles from Aminopyridines.
Authors: Debenham Sheryl D. , Chan Audrey , Liu Kun , Price Karen , Wood Harold B.
Published: June 2005

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Nonpeptide αvβ3 Antagonists: Identification of Potent, Chain‐Shortened 7‐Oxo RGD Mimetics.
Authors: Zartman Amy E. , Duong Le T. , Fernandez‐Metzler Carmen , Hartman George D. , Leu Chih‐Tai , Prueksaritanont Thomayant , Rodan Gideon A. , Rodan Sevgi B. , Duggan Mark E. , Meissner Robert S.
Published: June 2005

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Potent Pyrimidinetrione‐Based Inhibitors of MMP‐13 with Enhanced Selectivity over MMP‐14.
Authors: Reiter Lawrence A. , et al. et al.
Published: June 2005

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Synthesis of Substituted Uracil Derivatives from the Acetates of the Baylis—Hillman Adducts.
Authors: Lee Chang Gon , Gowrisankar Saravanan , Kim Jae Nyoung
Published: June 2005

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Diastereoselectivity in the Cycloaddition of 1‐Benzyl‐2‐piperazinone Nitrone with Alkenes.
Authors: Bernotas Ronald C. , Sing Lily , Friedrich Dirk
Published: June 2005

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Design, Synthesis and Structure—Activity Relationship Studies of Hexahydropyrazinoquinolines as a Novel Class of Potent and Selective Dopamine Receptor 3 (D3) Ligands.
Authors: Ji Min , Chen Jianyong , Ding Ke , Wu Xihan , Varady Judith , Levant Beth , Wang Shaomeng
Published: June 2005

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New Four‐Component Ugi‐Type Reaction. Synthesis of Heterocyclic Structures Containing a Pyrrolo[1,2‐a][1,4]diazepine Fragment.
Authors: Ilyn Alexey P. , Trifilenkov Andrey S. , Kuzovkova Julia A. , Kutepov Sergey A. , Nikitin Alexandre V. , Ivachtchenko Alexandre V.
Published: June 2005

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Synthesis of Functionalized 1‐Benzoxepins by Tandem Ring‐Opening/Cyclocondensation of 3‐Bromoisoxazoles.
Authors: Kociolek Martin G. , Straub Nicholas G. , Schuster Jolene V.
Published: June 2005

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The Methoxyallene Approach to Oxacycles. Part 2. Stereoselective Synthesis of 2,3‐Disubstituted Oxepanes.
Authors: Perez Manuel , Canoa Pilar , Gomez Generosa , Teijeira Marta , Fall Yagamare
Published: June 2005

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Practical Protocol for the Palladium‐Catalyzed Synthesis of Arylphosphonates from Bromoarenes and Diethyl Phosphite.
Authors: Goossen Lukas J. , Dezfuli Mohammad K.
Published: June 2005

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Diastereoselective Synthesis of α,β‐Unsaturated Systems.
Authors: Castelani Priscila , Comasseto Joao V.
Published: June 2005

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The Novel Functional Chromophores Based on Squarylium Dyes.
Authors: Park Soo‐Youl , Jun Kun , Oh Sea‐Wha
Published: June 2005

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YM‐216391, a Novel Cytotoxic Cyclic Peptide from Streptomyces nobilis. Part 1. Fermentation, Isolation and Biological Activities.
Authors: Sohda Kin‐ya , Nagai Koji , Yamori Takao , Suzuki Ken‐ichi , Tanaka Akihiro
Published: June 2005

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Synthesis of Methylene Exoglycals Using a Modified Julia Olefination.
Authors: Gueyrard David , Haddoub Rose , Salem Amine , Bacar Nassib Said , Goekjian Peter G.
Published: June 2005

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6‐O‐Silyl‐N‐acetyl‐2‐amino‐2‐N,3‐O‐carbonyl‐2‐deoxyglucosides: Effective Glycosyl Acceptors in the Glucosamine 4‐OH Series. Effect of Anomeric Stereochemistry on the Removal of the Oxazolidinone Group.
Authors: Crich David , Vinod A. U.
Published: June 2005

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One‐Pot Synthesis of Triazole‐Linked Glycoconjugates.
Authors: Chittaboina Srinivas , Xie Fang , Wang Qian
Published: June 2005

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A New Antibiotic, Antimycin A9, Produced by Streptomyces sp. K01‐0031.
Authors: Shiomi Kazuro , Hatae Kenji , Hatano Hiroko , Matsumoto Atsuko , Takahashi Yoko , Jiang Cheng‐Lin , Tomoda Hiroshi , Kobayashi Susumu , Tanaka Haruo , Omura Satoshi
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Microwave‐Assisted Michael Addition of Some Pyrimidine and Purine Nucleobases with α,β‐Unsaturated Esters: A Rapid Entry into Carboacyclic Nucleoside Synthesis.
Authors: Khalafi‐Nezhad A. , Zarea A. , Soltani Rad M. N. , Mokhtari B. , Parhami A.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Total Synthesis and Biological Activities of (+)‐Sulfamisterin (AB5366) and Its Analogues.
Authors: Sato Hideyuki , Maeba Takaki , Yanase Ryota , Yamaji‐Hasegawa Akiko , Kobayashi Toshihide , Chida Noritaka
Published: June 2005

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Absolute Configuration of Kigamicins A, C and D.
Authors: Someno Tetsuya , Kunimoto Setsuko , Nakamura Hikaru , Naganawa Hiroshi , Ikeda Daishiro
Published: June 2005

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Discovery of an Exceptionally Potent and Selective Class of Fatty Acid Amide Hydrolase Inhibitors Enlisting Proteome‐Wide Selectivity Screening: Concurrent Optimization of Enzyme Inhibitor Potency and Selectivity.
Authors: Leung Donmienne , Du Wu , Hardouin Christophe , Cheng Heng , Hwang Inkyu , Cravatt Benjamin F. , Boger Dale L.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Tryptamine and Homotryptamine‐Based Sulfonamides as Potent and Selective Inhibitors of 15‐Lipoxygenase.
Authors: Weinstein David S. , et al. et al.
Published: June 2005

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Synthesis and Activity of 4,5‐Diarylimidazoles as Human CB1 Receptor Inverse Agonists.
Authors: Plummer Christopher W. , et al. et al.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
3‐D Molecular Assembly of Function in Titania‐Based Composite Material Systems
Authors: Bartl Michael H. , Boettcher Shannon W. , Frindell Karen L. , Stucky Galen D.
Published: June 2005

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Directed Assembly of Metal—Cyanide Cluster Magnets
Authors: Beltran Lianne M. C. , Long Jeffrey R.
Published: June 2005

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Nanozeolites: Synthesis, Crystallization Mechanism, and Applications
Authors: Tosheva Lubomira , Valtchev Valentin P.
Published: June 2005

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45 Years of Nickel Hydride
Authors: Baranowski B. , Filipek S. M.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Growth and Characterization of Magnetooptic Garnet Films with Planar Uniaxial Anisotropy
Authors: Fratello Vincent J. , Mnushkina Irina , Licht Steven J. , Abbott Robert R.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Catalytic Studies in Electrochemical Membrane Reactors
Authors: Marnellos George , Stoukides Michael
Published: June 2005

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A View on the Future of Mixed Oxide Catalysts
Authors: Misono Makoto
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Design of Resolving Agents Based on Crystal Engineering
Authors: Kinbara Kazushi
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Cinchona Alkaloid Derivatives as Chiral Organocatalysts
Authors: Dalaigh Ciaran O.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Aza‐C‐disaccharides (Dideoxyimino‐alditols C‐Linked to Monosaccharides) and Analogues
Authors: Robina Inmaculada , Vogel Pierre
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
The Studies on the Structure—Activity Relationship of Allyl Substituted Oxopyrimidines Searching for the Novel Antagonist or Agonist of Barbiturates to the Sleep Mechanism Based on Uridine Receptor Theory — Barbituric Acid to Uridine. Part 1.
Authors: Yamamoto Ikuo
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Asymmetric Syntheses Promoted by Organoselenium Reagents
Authors: Tiecco M. , Testaferri L. , Marini F. , Bagnoli L. , Santi C. , Temperini A. , Sternativo S. , Tomassini C.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
New Synthesis of Selenophenes and Condensed Ring Systems from Ketene Dithioacetals
Authors: Sommen G. , Comel A. , Kirsch G.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Generation of Selenoaldehydes via Retro Diels—Alder Reaction and Their Behavior in the Reaction with Some Enophiles
Authors: Segi Masahito , Zhou Aojia , Honda Mitsunori
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Involvement of the Diels—Alderases in the Biosynthesis of Natural Products
Authors: Oikawa Hideaki
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Conformational Rigidity and Flexibility of the Paracyclophane Skeleton in Substituted [2.2]Paracyclophanes
Authors: Starikova Z. A. , Fedyanin I. V. , Antipin M. Yu.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Advances in Fullerene Chemistry
Authors: Stankevich I. V. , Sokolov V. I.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Organofunctional Metal Oxide Clusters as Building Blocks for Inorganic—Organic Hybrid Materials
Authors: Schubert Ulrich
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Catalyst Catastrophes
Authors: Roberts Mike P.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Isoindolinones: Angular Stones in Alkaloid Synthesis
Authors: Grandclaudon P.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Mono‐ and Bis(hydroxylamino)silanes [Sic]: Synthesis, Isomerisation and Quantum Chemical Calculations
Authors: Ebker Christina , Schmatz Stefan , Diedrich Friedhelm , Klingebiel Uwe
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Alkylidenephosphonium Salts
Authors: Niecke E. , Ruban A. , Raab M.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Design and Syntheses of Bioactive 1,2,4‐Triazolo[1,5‐a]‐pyrimidine Compounds
Authors: Yang Guangfu , Yang Huazheng
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Secondary Metabolites of Slime Molds (Myxomycetes).
Authors: Dembitsky Valery M. , Rezanka Tomas , Spizek Jaroslav , Hanus Lumir O.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
From Physical Pharmacy to Clinical Pharmacology
Authors: Nakano Masahiro
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Effects of Chinese Herbal Medicines on Intestinal Drug Absorption
Authors: Nishimura Nobuhiro
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Beyond Oil and Gas: The Methanol Economy
Authors: Olah George A.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Water and Aqueous Environments: On‐Line Chemical Analysis, Problems and Solutions
Authors: Moskvin A. L. , Moskvin L. N.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Reflection on Medium Effects on Photochemical Reactivity
Authors: Liu Robert S. H. , Hammond George S.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Gas‐Phase Fragmentation of Oligonucleotide Ions
Authors: Wu Jin , McLuckey Scott A.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Development of the Method for Analysis of the Cytokine Balance Shift Associated with Diseases
Authors: Okamoto Yoshihiro
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
ESR Spectrometry: A Future‐Oriented Tool for Dosimetry and Dating
Authors: Regulla Dieter F.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
The Influence of Halogens on the Electronic System of Biologically Important Ligands: Spectroscopic Study of Halogenobenzoic Acids, Halogenobenzoates and 5‐Halogenouracils
Authors: Lewandowski W. , Kalinowska M. , Lewandowska H.
Published: June 2005

For Abstract see ChemInform Abstract in Full Text.
Br2(X) Microsolvation in Helium Clusters: Effect of the Interaction on the Quantum Solvent Density Distribution
Authors: Di Paola Cono , Gianturco Franco A. , López‐Durán David , de Lara‐Castells Maria Pilar , Delgado‐Barrio Gerardo , Villarreal Pablo , Jellinek Julius
Published: June 2005

The Born–Oppenheimer potential energy surface for the Br2(X) molecule interacting with a varying number of 4He bosons is constructed following two different schemes which employ either a full ab initio evaluation of the Br2–He interaction forces or an estimate of the latter through an empirical model. Both descriptions are employed by carrying out diffusion Monte Carlo (DMC) calculations of the ground‐state energies and quantum wavefunctions for Br2–(He)n clusters with n up to 24. The results clearly indicate, for both interactions, the occurrence of the full solvation of the molecular dopant within the quantum bosonic “solvent” but also show differences between the two models in terms of the expected density distributions of the surrounding particles within the shorter‐range region that makes up the clusters with smaller n values. Our calculations also show that such differences become insignificant for the larger 4He clusters surrounding the Br2 molecule, where density profiles and bulk behaviour are chiefly driven by the solvent structure, once n values reach the region of 15–20 adatoms.
Assessment of Density Functionals for the High‐Spin/Low‐Spin Energy Difference in the Low‐Spin Iron(II) Tris(2,2′‐bipyridine) Complex
Authors: Lawson Daku Latévi Max , Vargas Alfredo , Hauser Andreas , Fouqueau Antony , Casida Mark Earl
Published: June 2005

In the iron(II) low‐spin complex [Fe(bpy)3]2+, the zero‐point energy difference between the 5T2g(t${{{4\hfill \atop 2g\hfill}}}$${e{{2\hfill \atop g\hfill}}}$) high‐spin and the 1A1g(t${{{6\hfill \atop 2g\hfill}}}$) low‐spin states, ΔE${{{0\hfill \atop HL\hfill}}}$, is estimated to lie in the range of 2500–5000 cm−1. This estimate is based on the low‐temperature dynamics of the high‐spin→low‐spin relaxation following the light‐induced population of the high‐spin state and on the assumption that the bond‐length difference between the two states ΔrHL is equal to the average value of ≈0.2 Å, as found experimentally for the spin‐crossover system. Calculations based on density functional theory (DFT) validate the structural assumption insofar as the low‐spin‐state optimised geometries are found to be in very good agreement with the experimental X‐ray structure of the complex and the predicted high‐spin geometries are all very close to one another for a whole series of common GGA (PB86, PW91, PBE, RPBE) and hybrid (B3LYP, B3LYP*, PBE1PBE) functionals. This confirmation of the structural assumption underlying the estimation of ΔE${{{0\hfill \atop HL\hfill}}}$ from experimental relaxation rate constants permits us to use this value to assess the ability of the density functionals for the calculation of the energy difference between the HS and LS states. Since the different functionals give values from −1000 to 12000 cm−1, the comparison of the calculated values with the experimental estimate thus provides a stringent criterion for the performance of a given functional. Based on this comparison the RPBE and B3LYP* functionals give the best agreement with experiment.
Synthesis, Structure and Luminescence Properties of Four Novel Terbium2‐Fluorobenzoate Complexes
Authors: Li Xia , Zhang Zhuo‐Yong , Zou Ying‐Quan
Published: June 2005

Four new complexes [Tb(2‐FBA)3·(2‐HFBA)·H2O]2 (1), {[Tb(2‐FBA)3·(4,4'‐bpy)·H2O]3}n (2), [Tb(2‐FBA)3·(2,2'‐bpy)]2 (3), and [Tb(2‐FBA)3·phen·CH3CH2OH]2·[Tb(2‐FBA)3·phen]2 (4) (2‐HFBA: 2‐fluorobenzoic acid; 4,4'‐bpy: 4,4'‐bipyridine; 2,2'‐bpy: 2,2'‐bipyridine; phen: 1,10‐phenanthroline) have been synthesized and characterized by X‐ray diffraction analysis. Complex 1 is a dimeric molecule with a one‐dimensional supramolecular structure formed by hydrogen bonds. Complex 2 is an infinite one‐dimensional polymer chain formed by bridging carboxylato groups; its 2D framework structure is formed by hydrogen bonds. The structure of complex 3 contains three independent binuclear molecules in the asymmetric unit. In two of them, two Tb3+ ions are held together by four 2‐FBA groups, with two of them in a bidentate‐bridging mode and the other two in a chelating‐bridging mode. In the third, two Tb3+ ions are held together by four 2‐FBA groups, all of which are in the bidentate‐bridging mode. One 2‐FBA group and one 2,2'‐bpy chelate to one Tb3+ ion, resulting in coordination numbers of the central terbium ion of nine and eight, respectively. The structure of complex 4 contains two nonequivalent binuclear molecules in the asymmetric unit — [Tb(2‐FBA)3·phen·CH3CH2OH]2 and [Tb(2‐FBA)3·phen]2. In the former, the Tb3+ ion is surrounded by eight atoms, five O atoms from five 2‐FBA groups, one O atom from one ethanol molecule and two N atoms from phen, and the 2‐FBA groups act in monodentate and bridging coordination modes. In the latter, the Tb3+ ion is coordinated by nine atoms, seven O atoms from five 2‐FBA groups and two N atoms of phen, and the 2‐FBA groups link the Tb3+ ion in chelating, bridging, and chelating‐bridging coordination modes. Complexes 1, 3, and 4 emit a bright green light under UV light in the solid state. There are four emission peaks in the luminescence spectra at 488, 543, 584, and 618 nm, corresponding to the 5D4→7F6, 5D4→7F5, 5D4→7F4, and 5D4→7F3 transitions, respectively, of the Tb3+ ion. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Novel Analogues of 5‐Fluorouracil – Synthesis, X‐ray Crystallography, and Cytotoxic Effects in Normal Human Peripheral Blood Lymphocytes and Colon Adenocarcinoma HT 29
Authors: Matlawska Ksenia , Kalinowska Urszula , Erxleben Andrea , Osiecka Regina , Ochocki Justyn
Published: June 2005

The aim of many studies is to discover new chemicals as potential antitumor agents. We have prepared novel analogues of 5‐fluorouracil (5‐Fu): 5‐uracilmethylphosphonic acid (5‐umpa), dimethyl 5‐uracilmethylphosphonate (5‐umpm), diethyl 5‐uracilmethylphosphonate (5‐umpe) and a K+ (K+/5‐umpa, 1) and Na+ (Na+/5‐umpa, 2) complex of 5‐umpa. Complexes 1 and 2 have infinite chain structures built up by H‐bonded pairs of 5‐umpa– and {(H2O)K(μ‐OH2)3K(OH2)}2+ and {(H2O)2Na(μ‐OH2)2Na(OH2)2}2+ entities. The alkali metal ions bind directly to the exocyclic oxygen atoms O(2) and O(4) of the nucleobase moiety and indirectly, i.e. through hydrogen‐bond interactions involving metal‐coordinated water molecules, to the phosphonate group. The new derivatives were tested for their antiproliferative and cytotoxic effects on normal human peripheral blood lymphocytes and HT 29 cancer lines in vitro using the tetrazolium salt (MTT) assay. The IC50 values were evaluated (the drug concentration inhibiting 50 % of the cell growth after 72 h exposure of cells to the drug). The results indicate that 5‐umpa, 5‐umpm, 5‐umpe, and the K+ and Na+ complexes of 5‐umpa do not exert toxic effects on regular lymphocytes and on the colon adenocarcinoma HT 29 cell line (IC50 > 1 mM), in comparison with 5‐Fu. However, an atypical course of survival curves was observed after treatment of HT 29 cells with 5‐umpa,5‐umpm and the Na+ complex of 5‐umpa. These observations suggest that it is very important to continue the studies in different biological systems in vitro and in vivo using various experimental protocols. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Fragmentation of Alkoxo(catecholato)vanadium(V) Complexes[(C6H4O2)V(OR1)(OR2)]+ in the Gas Phase
Authors: Kaczorowska Malgorzata , Schröder Detlef , Schwarz Helmut
Published: June 2005

Electrospray ionization (ESI) mass spectrometry is used to investigate the gas‐phase dissociation behavior of vanadium(V) complexes [(C6H4O2)V(OR1)(OR2)]+ containing two identical or different alkoxy groups (R1, R2 = CH3, C2H5, n‐C3H7, i‐C3H7 and t‐C4H9) and a catecholato ligand (C6H4O2). The fragmentation reactions of the complexes are studied by collision‐induced dissociation (CID) and labeling experiments. For [(C6H4O2)V(OR1)(OR2)]+ cations with alkoxo groups larger than methyl, a trend for preferential evaporation of hydrocarbon fragments is observed, followed by expulsion of neutral alcohols. Further, the CID spectra of all complexes show a signal which can be assigned to the complex [(C6H4O2)VO]+. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Novel Indenylzirconium Complexes as Supported Catalysts in the Polymerization of Ethylene
Authors: Alonso‐Moreno Carlos , Antiñolo Antonio , Carrillo‐Hermosilla Fernando , Carrión Pedro , López‐Solera Isabel , Otero Antonio , Prashar Sanjiv , Sancho José
Published: June 2005

A series of substituted indene {C9H7R‐3 [R = CH2CH2CH2OSiMe3 (1), CH2CH2CH2OCH2C6H5 (2), CH2CH2CH2OSiMe2tBu (3)]}, and ansa‐indene compounds {Me2Si(C9H6R‐3)2‐1[R = CH2CH2CH2OSiMe3 (4)], Me2Si(C9H6R‐3)‐1(C5HMe4) [R = CH2CH2CH2OSiMe3 (5), CH2CH2CH2OCH2C6H5 (6), CH2CH=CH2 (7), CH2CH2CH2OSiMe2tBu (8)]} have been prepared. The lithium derivatives of 1–8 were employed in the synthesis of the indenylzirconium complexes [Zr(η5‐C9H6R‐1)2Cl2] [R = CH2CH2CH2OSiMe3 (17), CH2CH2CH2OCH2C6H5 (18), CH2CH2CH2OSiMe2tBu (19)], rac‐[Zr{Me2Si(η5‐C9H5R‐3)2‐1}Cl2] [R = CH2CH2CH2OSiMe3 (20)], [Zr{Me2Si(η5‐C9H5R‐3)‐1(η5‐C5Me4)}Cl2] [R = CH2CH2CH2OSiMe3 (21), CH2CH2CH2OCH2C6H5 (22), CH2CH=CH2 (23), CH2CH2CH2OSiMe2tBu (24)] and [Zr(Me2Si{η5‐C9H5(CH2CH2CH2O)‐3}‐1{η5‐C5Me4})Cl] (21a). The alkyl complexes [Zr(Me2Si{η5‐C9H5(CH2CH2CH2O)‐3}‐1{η5‐C5Me4})Me] (25) and [Zr{Me2Si(η5‐C9H5R‐3)‐1(η5‐C5Me4)}Me2] [R = CH2CH2CH2OSiMe2tBu (26)] have been synthesized by the reaction of the corresponding ansa‐zirconocene derivative with the alkyl Grignard reagent. The molecular structure of [(Zr{C9H6(CH2CH2CH2O)‐1}Cl2)2(Zr–O)] (17a), a subproduct in the formation of 17 has been determined by single‐crystal X‐ray diffraction studies. The indenylzirconium complexes 17–24 have been immobilized on partially dehydroxylated SiO2, and these supported systems used to polymerize ethylene in the presence of methylaluminoxane. The catalytic activity of these compounds in both homogeneous and heterogeneous polymerization is reported. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Enrichment of low‐abundant serum proteins by albumin/immunoglobulin G immunoaffinity depletion under partly denaturing conditions
Authors: Huang Hong‐Lei , Stasyk Taras , Morandell Sandra , Mogg Maurice , Schreiber Martin , Feuerstein Isabel , Huck Christian W. , Stecher Guenther , Bonn Guenther K. , Huber Lukas A.
Published: June 2005

We present a simple protocol for affinity depletion to remove the two most abundant serum proteins, albumin and immunoglobulin G (IgG). Under native conditions, albumin/IgG were efficiently removed and several proteins were enriched as shown by two‐dimensional electrophoresis (2‐DE). Besides that, partly denaturing conditions were established by adding 5 or 20% acetonitrile (ACN) in order to disrupt the binding of low‐molecular‐weight (LMW) proteins to the carrier proteins albumin/IgG. 2‐DE results showed that the total number of detected LMW proteins increased under denaturing conditions when compared to native conditions. Interestingly, the presence of 5% ACN in serum revealed better enrichment of LMW proteins when compared to 20% ACN condition. Seven randomly distributed spots in albumin/IgG depleted serum samples under 5% ACN condition were picked from the 2‐DE gels and identified by mass spectrometry (MS). The intensity of five LMW protein spots increased under denaturing conditions when compared to native conditions. Three of the seven identified spots (serum amyloid P, vitamin D‐binding protein, and transthyretin) belong to a group of relatively low‐abundant proteins, which make up only 1% of all serum proteins. The method presented here improves the resolution of the serum proteome by increasing the number of visualized spots on 2‐D gels and allowing the detection and MS identification of LMW proteins and proteins of lower abundance.
Rolf Huisgen: A Gentleman Scholar with Energy and Passion
Authors: Seeman Jeffrey I.
Published: June 2005

A brief personal tribute to Professor and Mrs. Rolf Huisgen is presented. The essay describes Rolf Huisgen's energy and passion for science and art. Quotations from Huisgen's autobiography ‘The Adventure Playground of Mechanisms and Novel Reactions’ as well as many quotes from his correspondence with the author are presented. The essence and personality of this gentleman scholar are further highlighted by a number of photographs of him and of Trudl and other friends and colleagues.
Synthesis of the Cyclopentyl Nucleoside (−)‐Neplanocin A from D‐Glucose via Zirconocene‐Mediated Ring Contraction
Authors: Paquette Leo A. , Tian Zhenjiao , Seekamp Christopher K. , Wang Tony
Published: June 2005

Two approaches for the conversion of d‐glucose to (−)‐neplanocin A (2), both based on the zirconocene‐promoted ring contraction of a vinyl‐substituted pyranoside, are herein evaluated (Scheme 1). In the first pathway (Scheme 2), the substrate possesses the α‐d‐allo configuration (see 6) such that ultimate introduction of the nucleobase would require only an inversion of configuration. However, this precursor proved unresponsive to Cp2Zr (=[ZrCl2(Cp)2]), an end result believed to be a consequence of substantive nonbonded steric effects operating in a key intermediate (Scheme 5). In contrast, the C(2) epimer (see 7) experienced the desired metal‐promoted conversion to an enantiomerically pure polyfunctional cyclopentane (see 5 in Scheme 3). The substituents in this product are arrayed in a manner such that conversion to the target nucleoside can be conveniently achieved by a double‐inversion sequence (Scheme 4). Recourse to palladium(0)‐catalyzed allylic alkylation did not provide an alternate means of generating 2.
Use of Tröger's Base as a Scaffold for New Chiral Molecular Tweezers: Synthesis of Trimeric, Fused Tröger's Bases
Authors: Mas Thierry , Pardo Carmen , Elguero José
Published: June 2005

Four novel molecular tweezers, 6–9, have been synthesized having, for the first time, three fused Tröger's bases. The compounds differ in the relative configuration of the three fused methylene bridges and have been unambiguously characterized by NMR.
Control of the Interactions in Multichromophores: Novel Concepts. Perylene Bis‐imides as Components for Larger Functional Units
Authors: Langhals Heinz
Published: June 2005

The controlling of the internal interaction in multichromophores leads to functional dyes with novel properties. Such a controlling is demonstrated with perylene dyes and offers a manifold of novel possibilities.
Catalytic Decomposition of Diazo Compounds as a Method for Generating Carbonyl‐Ylide Dipoles
Authors: Padwa Albert
Published: June 2005

The transition metal catalyzed reaction of α‐diazo carbonyl compounds has found numerous applications in organic synthesis, and its use in either heterocyclic or carbocyclic ring formation is well‐precedented. In contrast to other catalysts that are suitable for carbenoid reactions of diazo compounds, those constructed with the dirhodium(II) framework are most amenable to ligand modification that, in turn, can influence reaction selectivity. The reaction of rhodium carbenoids with carbonyl groups represents a very efficient method for generating carbonyl ylide dipoles. Rhodium‐mediated carbenoid–carbonyl cyclization reactions have been extensively utilized as a powerful method for the construction of a variety of novel polycyclic ring systems. This article will emphasize some of the more recent synthetic applications of the tandem cyclization/cycloaddition cascade for natural product synthesis. Discussion centers on the chemical behavior of the rhodium metal–carbenoid complex that is often affected by the nature of the ligand groups attached to the metal center.
The Effect of Ring Size on Reactivity: The Diagnostic Value of ‘Rate Profiles’
Authors: Masson Eric , Leroux Frédéric
Published: June 2005

The rates of cycloalkyl phenyl sulfide formation of a series of homologous bromocycloalkanes upon treatment with sodium benzenethiolate have been determined to ascertain the effect of ring size on reactivity. The ‘rate profile’, i.e., reaction rate vs. ring size, for these nucleophilic substitutions (SN2) was determined. A linear free‐energy relationship could be derived from computed hydride affinities of cycloalkanes and rates of typical SN1 reactions, whereas rates of SN2 reactions exhibited a strong discrepancy from the seven‐ up to the twelve‐membered rings. This discrepancy was rationalized by a careful examination of the geometry of the intermediates and transition states involved in these reactions.
Stereoselective Synthesis of Tetrahydrofuran Spiro‐β‐Lactams by Ru‐Catalyzed Metathesis of 7‐Oxabicyclo[2.2.1]heptenes
Authors: Csákÿ Aurelio G. , Medel Rocío , Murcia M. Carmen , Plumet Joaquín
Published: June 2005

A new method for the synthesis of spiro‐β‐lactams tethered to tetrahydrofuran rings is described. The procedure is based on Ru‐catalyzed metathesis sequences with oxanorbornene precursors easily obtained by the Staudinger [2+2] cycloaddition of related imines.
Cycloadditions of Bifunctional Vinyl Ethers with Electrophilic Alkenes through Tetramethylene Zwitterion Intermediates
Authors: May Eric J. , Padias Anne Buyle , Bates Robert B. , Hall Henry K.
Published: June 2005

Bifunctional vinyl ethers react with electron‐poor alkenes to cyclobutanes in good yields. The second CC bond reacted with neither the cyclobutane nor its zwitterion intermediate, even on heating. Cyclobutanes formed from ‘tetracyanoethylene’ (8) were transformed into tetrahydropyridines by reaction of the corresponding zwitterion with MeCN as the solvent. In contrast, cyclobutanes formed from dimethyl (dicyanomethylidene)propanedioate (9) did not react with MeCN, which is ascribed to diminished stabilization of the zwitterion intermediate, and increased steric effects. These results extend the classical studies of Huisgen and his co‐workers.
Gas‐Phase Reactions of Homo‐ and Heteronuclear Clusters MM′+ (M, M′=Fe, Co, Ni) with Linear Alkanenitriles
Authors: Schlangen Maria , Schröder Detlef , Schwarz Helmut
Published: June 2005

Fourier‐transform ion‐cyclotron‐resonance mass spectrometry is used to investigate the reactions of mass‐selected homo‐ and heteronuclear clusters MM′+ (M, M′=Fe, Co, Ni) with linear alkanenitriles. The reactions with pentanenitrile are examined in detail by means of deuterium‐labeling studies. In comparison to the previously studied atomic cations Fe+, Co+, and Ni+, the diatomic cluster cations react more specifically and only insert in CH bonds in the initial step, whereas the bare ions M+ activate both CH and CC bonds. Like for the atomic cations, dehydrogenation proceeds via remote functionalization of the terminal positions of the substrate, although H‐scrambling processes, preceding dehydrogenation, are more pronounced for the dinuclear cluster cations. The Ni‐containing cluster cations CoNi+ and Ni$\rm{_{2}^{+}}$ are unique in that they bring about double dehydrogenation as well as activation of CC bonds subsequently to the first dehydrogenation. The latter kind of reaction is also partly observed for the [RCN−H2]‐complexes of FeCo+, Co$\rm{_{2}^{+}}$, and FeNi+ in their secondary reactions with pentanenitrile. The behavior of the Fe‐containing cluster cations Fe$\rm{_{2}^{+}}$ and FeCo+ is more subtle compared to that of the Ni‐containing clusters Ni$\rm{_{2}^{+}}$ and CoNi+ as well as that of homonuclear Co$\rm{_{2}^{+}}$. Based on extensive labeling experiments, dehydrogenation of pentanenitrile by these cluster cations follows a 1,2‐elimination mode, whereas loss of H2 from the Fe$\rm{_{2}^{+}}$ and FeCo+ complexes of the substrate proceeds to some extent via a 1,1‐elimination involving the unactivated Me group of the substrate. A more quantitative description of the labeling distribution has been achieved by extensive modeling.
The Chemistry of the Thiosulfinyl Group: Preparation, Structure, and Spectroscopic and Chemical Properties of Cyclic Thionosulfites
Authors: Nakayama Juzo , Yoshida (nee Tanaka) Sanae , Sugihara Yoshiaki , Sakamoto Akira
Published: June 2005

Treatment of the tetrahydrothiophene‐3,4‐diol 5 with 1,1′‐thiobis‐(1H‐benzimidazole) (6) furnished two diastereoisomers of the novel cyclic thionosulfite 4 with different configurations at the pseudo‐tetrahedral center of the thiosulfinyl (SS) group. The configuration of the SS group of the major diastereoisomer (isolated in 45% yield) was established to be syn to the thiolane ring, as determined by X‐ray crystallographic analysis, while that of the minor diastereoisomer (isolated in 10% yield) was anti. 1H‐NMR Spectroscopic analysis clarified that the shielding and deshielding zones of the SS group are similar to those of the well‐documented SO group. Characteristic absorptions of the SS group in the IR, Raman, and UV/VIS spectra were assigned on the basis of calculations at the B3LYP/6‐31G* level. The reactivity of the SS group toward thermolysis, hydrolysis, and oxidation was examined. The SS group is more resistant toward oxidation than the divalent sulfide S‐atom, but is oxidatively converted to the SO group.
Vicinal Diamination of Terminal Olefins
Authors: Pfaendler Hans Rudolf , Klingl Alexander
Published: June 2005

The present publication describes an efficient and mild three‐step conversion of a terminal olefin 1 into the corresponding 1,2‐diamine 5. The sequence includes: azidoiodination, substitution with NaN3, and catalytic hydrogenolysis. The terminal 1,2‐diamine 5 was converted into its cis‐dichloroplatinum(II) complex 6.
Tropone Is a Mere Ketone for Cycloadditions to Ketenes
Authors: Okamoto Junko , Yamabe Shinichi , Minato Tsutomu , Hasegawa Toshio , Machiguchi Takahisa
Published: June 2005

Tropone (1) reacts with ketenes 2 to yield [8+2] cycloadducts, the γ‐lactones 3. The concerted [8+2] cycloaddition path is formally symmetry‐allowed, but we established that it is unfavorable. Careful low‐temperature NMR (1H, 13C, and 19F) spectroscopies of the reaction of diphenyl ketene (2b) or bis(trifluoromethyl) ketene (2c) with tropone (1) allowed the direct detection of a β‐lactone intermediates 5b,c and novel norcaradiene species 6b,c in head‐to‐head configurations. The [2+2] cycloadducts 5b,c equilibrated with the norcaradienes 6b,c. The β‐lactones 5b and 5c were converted to the γ‐lactones 3b and 3c, respectively, in quantitative yields. The DFT calculations showed that the concerted [8+2] cycloaddition is unfavorable. The first step of the calculated reaction 1+2c is a cycloaddition which leads to a dioxetane intermediate. This initial [2+2] cycloadduct is isomerized to the β‐lactone 5c via the first zwitterionic intermediate. The β‐lactone 5c is further isomerized to the product γ‐lactone 3c via the second zwitterion intermediate. Thus, 3c is not formed via the well‐established two‐step mechanism including zwitterionic intermediates but via a five‐step mechanism composed of a [2+2] cycloaddition and subsequent isomerization (Scheme 12).
Thermal Isomerization of 12‐Oxa‐1,9‐dimetylhexacyclo[7.2.1.02,4.02,8.03,7.06,8]dodec‐10‐ene: A Computational Mechanistic Investigation
Authors: Glück‐Walther Susanne , Szeimies Günter
Published: June 2005

Flash‐vacuum pyrolysis of the quadricyclane derivative 5a at 350° afforded the oxabishomocubane 9a, whose structure was confirmed by an INADEQUATE‐NMR experiment. A computational investigation of the mechanism of this unexpected reaction by DFT and CASPT2‐SCF methods indicated that the reaction path of lowest energy involves a quadricyclane/oxaquadricyclane (5/12) isomerization, followed by a well‐established cycloreversion of 12 to the carbonyl ylide 16, which subsequently undergoes an intramolecular 1,3‐dipolar cycloadditon to 9. The lowest‐energy path of the thermal isomerization of the syn‐quadricyclane 6c is its conversion to the syn‐sesquinorbornatriene 8c. The corresponding anti‐isomer 5c, however, shows the capability of a degenerate quadricyclane/quadricyclane rearrangement.
Prostaglandins and reproduction in male lizard, Podarcis sicula sicula
Authors: Gobbetti Anna , Zerani Massimo , di Fiore Maria Maddalena
Published: June 2005

The possible role of prostaglandins in the reproductive processes of the male lizard, Podarcis sicula sicula, was investigated. The plasma levels of prostaglandin F2α (PGF2α), prostaglandin E2 (PGE2), progesterone, androgens, and 17β‐estradiol, and the in vitro basal release of these hormones by testis, epididymis and interrental, at different phases of the annual sexual cycle, were studied. In addition, the in vivo and in vitro effects of PGF2α and PGE2 on steroid production were evaluated. In in vivo experiments, PGF2α and 17β‐estradiol plasma levels were highest during the refractory phase; PGE2 values were lowest and androgens highest in fighting phase. PGF2α injection increased 17β‐estradiol in refractory phase; PGE2 increased androgens in fighting phase and 17β‐estradiol in refractory phase. In in vitro experiments, testis released the highest levels of PGF2α and 17β‐estradiol in refractory phase, and of PGE2 and androgens in fighting phase. Interrenal released the highest levels of PGF2α, PGE2, and 17β‐estradiol in refractory phase, and of androgens in fighting phase. Epididymis released the highest values of PGF2α and PGE2 in mating phase. PGF2α treatment increased 17β‐estradiol release by testis and interrenals in refractory phase. PGE2 treatment increased androgen release by testis in fighting phase and 17β‐estradiol release by interrenal in refractory phase. The present data indicate that in male lizards, P. s. sicula, testicular androgen synthesis during the fighting phase is under the control of PGE2, while 17β‐estradiol synthesis during refractory phase is regulated in the testis by PGF2α and in interrenal by PGF2α and PGE2. © 1994 Wiley‐Liss, Inc.
Cardiac CINE imaging with IDEAL water‐fat separation and steady‐state free precession
Authors: Reeder Scott B. , Markl Michael , Yu Huanzhou , Hellinger Jeffrey C. , Herfkens Robert J. , Pelc Norbert J.
Published: June 2005

Purpose

to decompose multicoil CINE steady‐state free precession (SSFP) cardiac images acquired at short echo time (TE) increments into separate water and fat images, using an iterative least‐squares “Dixon” (IDEAL) method.

Materials and Methods

Multicoil CINE IDEAL‐SSFP cardiac imaging was performed in three volunteers and 15 patients at 1.5 T.

Results

Measurements of signal‐to‐noise ratio (SNR) matched theoretical expectations and were used to optimize acquisition parameters. TE increments of 0.9–1.0 msec permitted the use of repetition times (TRs) of 5 msec or less, and provided good SNR performance of the water‐fat decomposition, while maintaining good image quality with a minimum of banding artifacts. Images from all studies were evaluated for fat separation and image quality by two experienced radiologists. Uniform fat separation and diagnostic image quality was achieved in all images from all studies. Examples from volunteers and patients are shown.

Conclusion

Multicoil IDEAL‐SSFP imaging can produce high quality CINE cardiac images with uniform water–fat separation, insensitive to Bo inhomogeneities. This approach provides a new method for reliable fat‐suppression in cardiac imaging. J. Magn. Reson. Imaging 2005;22:44–52. © 2005 Wiley‐Liss, Inc.
Peritumoral fat‐spared area is well correlated with the presence of temporal peritumoral enhancement in hepatic hemangioma in fatty liver
Authors: Chen Ran‐Chou , Li Chao‐Shiang , Lii Jiunn‐Ming , Chen Wei‐Tsung , Tu Hsing‐Yang
Published: June 2005

Purpose

To assess the relationship between temporal peritumoral enhancement and peritumoral focal fat sparing adjacent to hepatic hemangiomas.

Materials and Methods

On the basis of MRI and sonographic imaging follow‐up, 51 hepatic hemangiomas were identified in 37 patients, who had both hepatic hemangiomas and focal fat‐sparing areas in fatty liver. Among them, 36 tumors were associated with peritumoral focal fat spares. The association between the temporal peritumoral enhancement in the early arterial phase of dynamic MRI and peritumoral fat sparing in the same hemangioma was investigated. Furthermore, the configuration of the temporal peritumoral enhancement was correlated with that of the peritumoral focal fat‐sparing area. We used Chi square and Fisher's exact test for statistic analysis.

Results

A total of 31 out of 36 hemangiomas (86.1%) showed both peritumoral focal fat spares and temporal peritumoral enhancement. The presence of temporal peritumoral enhancement is significantly related to that of peritumoral focal fat‐sparing (P < 0.001). A total of 21 of the 31 tumors (67.7%) presented with similar configuration of the peritumoral focal fat‐sparing area and temporal peritumoral enhancement area with respect to size and shape. The remaining 10 hemangiomas showed similar shape but slightly different size in these two imaging characteristics.

Conclusion

Temporal peritumoral enhancement seen in hepatic hemangioma might be related to focal fatty sparing adjacent to the hemangiomas. J. Magn. Reson. Imaging 2005;22:86–91. © 2005 Wiley‐Liss, Inc.