bluuebunny/crossref_metadata_2025 huggingface dataset:
The Prevalence of Mental Problems for Chinese Children and Adolescents During COVID-19 in China: A Systematic Review and Meta-Analysis
Authors: Chai Jiabao , Xu Huili , An Ning , Zhang Pan , Liu Fuquan , He Sushuang , Hu Na , Xiao Xue , Cui Yonghua , Li Ying
Published: October 2021

The outbreak of coronavirus disease 2019 (COVID-19) has caused mental problems among the public and medical staff in China, especially for children and adolescents, a vulnerable group that might present with more mental problems. It seems that there is a rapid growth in the mental problems (such as depression or anxiety) of Chinese children and adolescents during the outbreak of COVID-19. Although several studies reported the prevalence of depression or anxiety problems for children and adolescents, the results are different across different age groups and sex groups. Moreover, the sample size of these studies was small. In the present study, we aim to perform a meta-analysis to identify the confirmed prevalence of depression and anxiety problems for Chinese children and adolescents during home confinement. Five databases were searched including PubMed, Web of Science, PsycINFO, Google Scholar, and the China National Knowledge Infrastructure (CNKI), and both inclusion and exclusion criteria were developed. Finally, a total of 12 studies were included in this meta-analysis. The protocol of this systematic review was registered with INPLASY (protocol ID: INPLASY202150032). It found that the pooled prevalence of mental problems was 28% (95% confidence interval, CI: 0.22–0.34), and the depression and anxiety problem for children and adolescents in China was 22% (95% CI: 0.16–0.30) and 25% (95% CI: 0.20–0.32) based on a random effect model, separately. Subgroup analysis was used to identify that there are no differences between different age groups (primary and middle school vs. high school) (p = 0.26). Meta-regression analysis was performed and the results showed that the moderator of boy percentage was a significant factor (p = 0.04). It indicated that there was an increasing number of children and adolescents with mental problems during the home confinement. It suggested that we should pay more attention to this vulnerable population during a public health crisis in the future, especially for the girls groups, and more detailed implements for mental health management were needed and should be prepared.

Systematic Review: The protocol of this systematic review was registered with INPLASY. The protocol ID was INPLASY202150032
Association Between the COVID-19 Pandemic and Infant Neurodevelopment: A Comparison Before and During COVID-19
Authors: Huang Peiyuan , Zhou Fengjuan , Guo Yixin , Yuan Shanshan , Lin Shanshan , Lu Jinhua , Tu Si , Lu Minshan , Shen Songying , Guedeney Antoine , Xia Huimin , Qiu Xiu
Published: October 2021

Aim: To investigate the association between the experience of the coronavirus disease 2019 (COVID-19) pandemic and neurodevelopment of 6-month-old and 1-year-old children and explore the differences in the association by birth order.

Methods: This comparison study was embedded in the Born in Guangzhou Cohort Study in China. The exposed group included 546 6-month-old and 285 1-year-old children who attended neurodevelopment assessments between March 1 and May 15, 2020, and the non-exposed group included 3,009 6-month-old and 2,214 1-year-old children during the same months from 2015 to 2019. Neurodevelopment at age 6 months and 1 year was assessed by trained clinical staff using the Ages and Stages Questionnaires, third edition (ASQ-3) and the Gesell Developmental Schedules (GDS).

Results: The experience of the pandemic in 2020 was associated with a higher risk of delay in the fine motor (adjusted OR: 2.50, 95% CI: 1.25, 4.99; estimated by logistic regression) and communication (adjusted RR [aRR]: 1.13, 95% CI: 1.02, 1.25; estimated by log-binomial regression) domains at age 1 year. The association between the experience of the pandemic and communication delay at age 1 year only existed in first-born children (aRR: 1.15, 95% CI: 1.03, 1.30) but not in later-born children (aRR: 1.02, 95% CI: 0.84, 1.25). No associations were observed in any domain among 6-month-olds.

Conclusion: Experiencing the COVID-19 pandemic and related public health strategies might be associated with a higher risk of delay in the development of fine motor and communication in 1-year-old children; the association observed in the communication domain only existed in first-born children.
Expanding Neonatal Bloodspot Screening: A Multi-Stakeholder Perspective
Authors: van Dijk Tessa , Kater Adriana , Jansen Marleen , Dondorp Wybo J. , Blom Maartje , Kemp Stephan , Langeveld Mirjam , Cornel Martina C. , van der Pal Sylvia M. , Henneman Lidewij
Published: October 2021

Neonatal bloodspot screening (NBS) aims to detect treatable disorders in newborns. The number of conditions included in the screening is expanding through technological and therapeutic developments, which can result in health gain for more newborns. NBS expansion, however, also poses healthcare, ethical and societal challenges. This qualitative study explores a multi-stakeholders' perspective on current and future expansions of NBS. Semi-structured interviews were conducted with 22 Dutch professionals, including healthcare professionals, test developers and policy makers, and 17 parents of children with normal and abnormal NBS results. Addressed themes were (1) benefits and challenges of current expansion, (2) expectations regarding future developments, and (3) NBS acceptance and consent procedures. Overall, participants had a positive attitude toward NBS expansion, as long as it is aimed at detecting treatable disorders and achieving health gain. Concerns were raised regarding an increase in results of uncertain significance, diagnosing asymptomatic mothers, screening of subgroups (“males only”), finding untreatable disorders, along with increasingly complex consent procedures. Regarding the scope of future NBS expansions, two types of stakeholder perspectives emerged. Stakeholders with a “targeted-scope” perspective saw health gain for the neonate as the exclusive NBS aim. They thought pre-test information could be limited, and parents should be protected against too much options or information. Stakeholders with a “broad-scope” perspective thought the NBS aim should be formulated broader, for example, also taking (reproductive) life planning into account. They put more emphasis on individual preferences and parental autonomy. Policy-makers should engage with both perspectives when making further decisions about NBS.
Astragalus Polysaccharide Reduces Blood Pressure, Renal Damage, and Dysfunction Through the TGF-β1-ILK Pathway
Authors: Zheng Wei , Huang Tao , Tang Qi-Zhen , Li Shi , Qin Jie , Chen Feng
Published: October 2021

Background:Astragalus polysaccharide extract (APS) has been shown to exhibit antioxidant and anti-inflammatory potential in the treatment of several diseases. However, whether APS could protect against renal damage in hypertensive mice is unknown.

Methods: Hematoxylin and eosin staining, immunohistochemistry, real-time polymerase chain reaction, and Western blotting were used to investigate the effect of APS on the renal damage in deoxycorticosterone acetate- (DOCA) salt- and angiotensin II- (Ang II-) induced hypertensive mice and to elucidate the underlying mechanisms.

Results: Our data demonstrated that APS significantly reduced blood pressure in DOCA-salt- and Ang II-treated mice. Furthermore, APS reduced the inflammatory response and renal fibrosis, thereby improving renal function. Furthermore, the levels of serum creatinine, urea nitrogen, and uric acid increased in DOCA-salt-treated mice, alleviated by APS administration. At the molecular level, DOCA-salt and Ang II increased the mRNA levels of IL-1β, IL-6, α-SMA, collagen I, and collagen III, while APS significantly inhibited these effects. APS inhibited the TGF-β1/ILK signaling pathway, which was activated in hypertensive mice due to the administration of DOCA-salt.

Conclusion: Our results suggest that APS plays a beneficial role in improving renal dysfunction in hypertensive mice.
Thermally Resilient Planar Waveguides in Novel nc-YSZ Transparent Ceramic by fs Laser Pulses
Authors: Castillo Gabriel R. , Burshtein Cecilia , Uahengo Gottlieb , Penilla Elías H. , Esqueda-Barrón Yasmín , Martinez-Gil M. , de la Cruz Wencel , Garay Javier E. , Camacho-López Santiago
Published: October 2021

We report on thermally resilient planar waveguides fabricated on nc-YSZ by direct fs-laser inscription in transparent nc-yttria stabilized zirconia (nc-YSZ) polycrystalline ceramic. The waveguides consisted of rectangular sections (4.5 × 2 mm2) on the surface of the sample. Optical characterization at 633 and 810 nm was performed. We estimate a laser-induced refractive index contrast of 10–4. Post-waveguide-fabrication thermal annealing treatments at 750°C for 24 h were carried out to test the resilience of the waveguides and to further reduce the waveguide losses. Both micro-Raman spectroscopy and XPS characterization revealed unmodified lattice and steady chemical features, which are consistent with the waveguide thermal resilience. Our results suggest a promising potential use of nc-YSZ in harsh and high temperature demanding photonic environments.
Arabidopsis MED18 Interaction With RNA Pol IV and V Subunit NRPD2a in Transcriptional Regulation of Plant Immune Responses
Authors: Zhang Yan , Shi Chengchen , Fu Weihong , Gu Xiaojing , Qi Ziyang , Xu Weizhong , Xia Gengshou
Published: October 2021

Mediator is a conserved multiprotein complex important for transcription by RNA polymerase II (Pol II). Arabidopsis Mediator subunit MED18 regulates flowering, hormone signaling and plant immunity. Here we report that Arabidopsis MED18 interacted with NUCLEAR RNA POLYMERASE D2a (NRPD2a), the second largest subunit of the nuclear Pol IV and V, which function in RNA-directed DNA methylation and epigenetic regulation of gene expression. Mutants for both MED18 and NRPD2a were compromised in resistance to necrotrophic fungal pathogen Botrytis cinerea. Mutants for NRPD1a, the largest subunit of Pol IV, were also compromised in resistance to Botrytis, supporting a critical role of Pol IV and V in plant defense against Botrytis. Increased Botrytis susceptibility of both the med18 and nrpd2a mutants were associated with reduced accumulation of reactive oxygen species, which are known to promote resistance to Botrytis. Both the basal and pathogen-induced levels of salicylic acid and jasmonic acid were also significantly altered in the med18 and nrpd2a mutants. Transcriptome profiling found that MED18 and NRPD2a affected both unique and overlapping sets of genes in a broad spectrum of biological processes and pathways that influence plant–pathogen interaction. The genes altered in expression in the med18 and nrpd2a mutants include disease resistance proteins, salicylic acid and jasmonic acid signaling and responses, which are known to affect resistance to necrotrophic pathogens. The novel interaction between subunits of Mediator and plant-specific RNA polymerases provides a new mechanism for epigenetic regulation of resistance and expression of defense-related genes in plant immunity.
Cell Wall Composition and Structure Define the Developmental Fate of Embryogenic Microspores in Brassica napus
Authors: Camacho-Fernández Carolina , Seguí-Simarro Jose M. , Mir Ricardo , Boutilier Kim , Corral-Martínez Patricia
Published: October 2021

Microspore cultures generate a heterogeneous population of embryogenic structures that can be grouped into highly embryogenic structures [exine-enclosed (EE) and loose bicellular structures (LBS)] and barely embryogenic structures [compact callus (CC) and loose callus (LC) structures]. Little is known about the factors behind these different responses. In this study we performed a comparative analysis of the composition and architecture of the cell walls of each structure by confocal and quantitative electron microscopy. Each structure presented specific cell wall characteristics that defined their developmental fate. EE and LBS structures, which are responsible for most of the viable embryos, showed a specific profile with thin walls rich in arabinogalactan proteins (AGPs), highly and low methyl-esterified pectin and callose, and a callose-rich subintinal layer not necessarily thick, but with a remarkably high callose concentration. The different profiles of EE and LBS walls support the development as suspensorless and suspensor-bearing embryos, respectively. Conversely, less viable embryogenic structures (LC) presented the thickest walls and the lowest values for almost all of the studied cell wall components. These cell wall properties would be the less favorable for cell proliferation and embryo progression. High levels of highly methyl-esterified pectin are necessary for wall flexibility and growth of highly embryogenic structures. AGPs seem to play a role in cell wall stiffness, possibly due to their putative role as calcium capacitors, explaining the positive relationship between embryogenic potential and calcium levels.
Metabolomics Analysis Reveals Drought Responses of Trifoliate Orange by Arbuscular Mycorrhizal Fungi With a Focus on Terpenoid Profile
Authors: Liang Sheng-Min , Zhang Fei , Zou Ying-Ning , Kuča Kamil , Wu Qiang-Sheng
Published: October 2021

Soil water deficit seriously affects crop production, and soil arbuscular mycorrhizal fungi (AMF) enhance drought tolerance in crops by unclear mechanisms. Our study aimed to analyze changes in non-targeted metabolomics in roots of trifoliate orange (Poncirus trifoliata) seedlings under well-watered and soil drought after inoculation with Rhizophagus intraradices, with a focus on terpenoid profile. Root mycorrhizal fungal colonization varied from 70% under soil drought to 85% under soil well-watered, and shoot and root biomass was increased by AMF inoculation, independent of soil water regimes. A total of 643 secondary metabolites in roots were examined, and 210 and 105 differential metabolites were regulated by mycorrhizal fungi under normal water and drought stress, along with 88 and 17 metabolites being up-and down-regulated under drought conditions, respectively. KEGG annotation analysis of differential metabolites showed 38 and 36 metabolic pathways by mycorrhizal inoculation under normal water and drought stress conditions, respectively. Among them, 33 metabolic pathways for mycorrhization under drought stress included purine metabolism, pyrimidine metabolism, alanine, aspartate and glutamate metabolism, etc. We also identified 10 terpenoid substances, namely albiflorin, artemisinin (−)-camphor, capsanthin, β-caryophyllene, limonin, phytol, roseoside, sweroside, and α-terpineol. AMF colonization triggered the decline of almost all differential terpenoids, except for β-caryophyllene, which was up-regulated by mycorrhizas under drought, suggesting potential increase in volatile organic compounds to initiate plant defense responses. This study provided an overview of AMF-induced metabolites and metabolic pathways in plants under drought, focusing on the terpenoid profile.
Making Localization Work: The Everyday Practice of Three NGOs in South Sudan and Northern Uganda
Authors: Dijkzeul Dennis
Published: October 2021

In humanitarian action, localization can be characterized by high hopes, many disillusions, and only limited progress. This is partly because traditional humanitarian action focuses mostly on short-term action and is supply-oriented, with decisions on the set-up and evaluation of aid activities being made by outside donors and organizations, instead of by the beneficiaries/target groups themselves. After a theoretical overview of localization and its problems, this article describes how two South Sudanese NGOs, Mary Help Association and Bishop Gassis Relief and Rescue Foundation (BGRRF), and a Ugandan NGO, Caritas Gulu, work on food security. It describes how they are implementing a 3-year program with support from Caritas Germany. The article analyzes the importance of their long-term interaction to foster trust over time through capacity development. Such capacity development includes capacity building (e.g., training, joint workshops, regular evaluations, and audits) and capacity sharing in the form of South-South cooperation. This analysis also shows that localization can be strengthened when the involved organizations agree on goals, and establish a process to reinforce their cooperation by strengthening the activities on the ground to achieve those goals. It also indicates the role of religion within capacity-development, as well as the structural problems in the context of localization that cannot easily be overcome. A conceptual model summarizes the analysis and explains the degree to which localization can be successful. Finally, the conclusions summarize the main arguments and indicate issues for further research.
The Change of a Changer: A Single Case Study of the Indigenization of a Chinese Counseling Psychologist
Authors: Wang Dongmei , Wang Baoyu
Published: October 2021

Over the past several decades, the increasing popularization of psychological counseling has underlined a strong need for an indigenous approach to counseling. The current study adopted a single-case study method to construct a narrative of the indigenization process of psychotherapy in mainland China based on a comprehensive description of one prominent counseling psychologist’s experience over the past half-century. Through interviews and records of fieldwork involving the psychologist (as the case) in 10 months between 2016 and 2017, the current study analyzed the indigenization process from the following three aspects: knowledge production, counseling practice, and student training. The findings showed that there was an underlying tension between the psychologist’s traditional wisdom and his professional training in scientific psychology during the indigenization process. However, the findings of this study further revealed something missing from previous studies. First, the client-centered counselor did not assume “power” during counseling sessions, which differs from critical viewpoints in medical anthropology. Second, the students being trained underwent fundamental changes in values rather than learning a technique or resolving problems. Third, the psychologist’s life history affected his thoughts and professional practice, which occurred in a sociocultural historical context. Finally, the implications for the future direction of the indigenization of counseling practice are discussed.
Does Whistleblowing on Tax Evaders Reduce Ingroup Cooperation?
Authors: Chapkovski Philipp , Corazzini Luca , Maggian Valeria
Published: October 2021

Whistleblowing is a powerful and rather inexpensive instrument to deter tax evasion. Despite the deterrent effects on tax evasion, whistleblowing can reduce trust and undermine agents’ attitude to cooperate with group members. Yet, no study has investigated the potential spillover effects of whistleblowing on ingroup cooperation. This paper reports results of a laboratory experiment in which subjects participate in two consecutive phases in unchanging groups: a tax evasion game, followed by a generalized gift exchange game. Two dimensions are manipulated in our experiment: the inclusion of a whistleblowing stage in which, after observing others’ declared incomes, subjects can signal other group members to the tax authority, and the provision of information about the content of the second phase before the tax evasion game is played. Our results show that whistleblowing is effective in both curbing tax evasion and improving the precision of tax auditing. Moreover, we detect no statistically significant spillover effects of whistleblowing on ingroup cooperation in the subsequent generalized gift exchange game, with this result being unaffected by the provision of information about the experimental task in the second phase. Finally, the provision of information does not significantly alter subjects’ (tax and whistleblowing) choices in the tax evasion game: thus, knowledge about perspective ingroup cooperation did not alter attitude toward whistleblowing.
Effects of Transcranial Direct Current Stimulation Treatment for Anorexia Nervosa
Authors: Baumann Silvie , Mareš Tadeáš , Albrecht Jakub , Anders Martin , Vochosková Kristýna , Hill Martin , Bulant Josef , Yamamotová Anna , Štastný Ota , Novák Tomáš , Holanová Petra , Lambertová Alena , Papežová Hana
Published: October 2021

Background: Anorexia nervosa (AN) is a life-threatening illness with poor treatment outcomes. Although transcranial direct current stimulation (tDCS) is a promising non-invasive brain stimulation method, its effect in patients with AN remains unclear.

Objective: This study investigated changes in maladaptive eating behavior, body mass index (BMI), and depression after 10 sessions of anodal tDCS over the left dorsolateral prefrontal cortex (DLPFC).

Methods: In this double-blind, randomized controlled trial, 43 inpatients with AN were divided to receive either active (n = 22) or sham (n = 21) tDCS over the left DLPFC (anode F3/cathode Fp2, 2 mA for 30 min). All patients filled the Eating Disorder Examination Questionnaire (EDE-Q) and Zung Self-Rating Depression Scale (ZUNG), and their BMI was measured. These values were obtained repeatedly in four stages: (1) before tDCS treatment, (2) after tDCS treatment, (3) in the follow-up after 2 weeks, and (4) in the follow-up after 4 weeks.

Results: Primary outcomes (EDE-Q) based on the ANOVA results do not show any between-group differences either after the active part of the study or in the follow-up. Secondary analysis reveals a reduction in some items of EDE-Q. Compared with sham tDCS, active tDCS significantly improved self-evaluation based on body shape (p < 0.05) and significantly decreased the need of excessive control over calorie intake (p < 0.05) in the 4-week follow-up. However, the results do not survive multiple comparison correction. In both sham and active groups, the BMI values improved, albeit not significantly.

Conclusion: We did not observe a significant effect of tDCS over the left DLPFC on complex psychopathology and weight recovery in patients with AN. tDCS reduced the need to follow specific dietary rules and improved body image evaluation in patients with AN. Tests with a larger sample and different positions of electrodes are needed.

Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT03273205.
Assessment of Childbirth-Related PTSD: Psychometric Properties of the German Version of the City Birth Trauma Scale
Authors: Weigl Tobias , Beck-Hiestermann Franziska Marie Lea , Stenzel Nikola Maria , Benson Sven , Schedlowski Manfred , Garthus-Niegel Susan
Published: October 2021

Background: About 3–4% of women in community samples suffer from childbirth-related posttraumatic stress disorder (PTSD). Surprisingly, the recently developed City Birth Trauma Scale (City BiTS) was the first diagnostic tool for childbirth-related PTSD covering DSM-5 criteria for PTSD. Since no questionnaire on childbirth-related PTSD is available in German, we aimed to validate a German translation of the City BiTS and to provide information on its psychometric properties.

Methods: A community sample of 1,072 mothers completed an online survey, which included questions on sociodemographic and obstetric characteristics, the German version of the City BiTS, the Impact of Event Scale-Revised (IES-R), the PTSD Checklist for DSM-5 (PCL-5), Edinburgh Postnatal Depression Scale (EPDS), and the anxiety subscale of the Depression, Anxiety, and Stress Scale (DASS-Anxiety).

Results: Exploratory factor analysis (EFA) on a random split-half sample confirmed the previously reported two-factorial structure of the City BiTS. The factors “Childbirth-related symptoms” and “General symptoms” explained about 53%, 52% of variance. Internal consistency was good to excellent for the subscales and the total scale (Cronbach's Alpha = 0.89−0.92). In a confirmatory factor analysis (CFA) in the holdout sample the two-factorial solution reached the best model fit out of three models. Correlation analyses showed convergent validity of the City BiTS (total scale and subscales) with the IES-R and PCL-5 and divergent validity with the EPDS and the DASS-Anxiety.

Limitations: Data were acquired in a community sample and prevalence rates might not be representative for mothers of high-risk groups, e.g., after preterm birth.

Conclusions: The German version of the City BiTS is the first German questionnaire which allows to assess symptoms of childbirth-related PTSD according to DSM-5 criteria. Besides an improvement in clinical routine it will help to make data on prevalence of childbirth-related PTSD internationally comparable. In addition, this work provides a basis to assess childbirth-related PTSD in studies conducted with a longitudinal study design or in high-risk samples.
Gaming and Social Media Addiction in University Students: Sex Differences, Suitability of Symptoms, and Association With Psychosocial Difficulties
Authors: Burén Jonas , Nutley Sissela B. , Sandberg David , Ström Wiman Johanna , Thorell Lisa B.
Published: October 2021

Background: Previous research has shown that addictions to digital media can have negative impact on psychosocial health. Although Internet Gaming Disorder (IGD) has received most scholarly recognition, the potential negative consequences of Social Media Disorder (SMD) have also been found. However, few studies have assessed the symptoms of these two digital media addictions in the same way, making comparisons difficult. The present study aims to fill this gap by investigating differences and similarities regarding how common the symptoms are, sex differences, the suitability of the symptoms, and their association with psychosocial difficulties.

Method: A total of 688 university students (63.2% women, Mean age = 25.98) completed a questionnaire measuring symptoms of IGD and SMD, as well as psychosocial difficulties (i.e., psychosomatic symptoms, low self-concept, and social problems).

Results: Results showed that 1.2% of the men and 0.9% of the women met the symptom criteria for IGD (non-significant difference), whereas 3.2% men and 2.8% women met the symptom criteria for SMD (non-significant difference). Dimensional analyses indicated that men had higher IGD scores compared to women, whereas the opposite was found for SMD. Symptoms of heavy involvement in digital media (i.e., Preoccupation, Tolerance, Withdrawal, Unsuccessful attempts to control, and Escape) had high sensitivity, but low positive predictive value (PPV). However, symptoms associated with negative consequences of digital media use (i.e., Loss of interest, Continued excessive use, Deception, and Jeopardizing career/relationships) had low sensitivity, but high PPV. These symptom patterns were similar for IGD and SMD. Meeting the criteria for IGD or SMD as well as being at risk of these disorders were significantly associated with psychosocial difficulties. Symptoms of SMD generally had stronger associations with psychosomatic symptoms compared to symptoms of IGD.

Conclusions: We conclude that heavy involvement in digital media seems common among individuals with IGD or SMD, but also among those not meeting the symptom criteria, whereas negative consequences are less common but highly predictive of digital media addictions once present. Further attention to SMD is warranted, as it seems more common than IGD and also seems to be equally or more strongly associated with psychosocial difficulties.
Predictors of Quality of Life in Patients With Myocardial Infarction Combined With Dyslipidemia
Authors: Zhang Mengran , Chen Pingyu , Zhang Yan , Su Xi , Chen Jiyan , Xu Biao , Tao Jianhong , Wang Zhen , Li Hongchao , Ma Aixia
Published: October 2021

Background: Dyslipidemia is an important risk factor for myocardial infarction (MI). This study aimed to examine the health-related quality of life (HRQoL) and its predictors of patients with MI combined with dyslipidemia in China.

Methods: Information on patients' sociological characteristics, lifestyle, clinical characteristics, and quality of life were collected by electronic medical records and questionnaires. Tobit regression model was used to investigate the predictors of quality of life.

Results: There were 756 patients responded. The average EQ-5D score of all the patients was 0.95 (SD: 0.11). For all patients, factors such as age, high-fat and high-cholesterol diet, sports, family history of dyslipidemia, history of peripheral artery disease significantly affected HRQoL.

Conclusions: Post-discharge care of the elderly group should be paid more attention to and suggestions on the healthy lifestyle (fat control) of the patients should be encouraged to improve the quality of life of these population.
Global Mental Health and Nutrition: Moving Toward a Convergent Research Agenda
Authors: Sparling Thalia M. , Cheng Bryan , Deeney Megan , Santoso Marianne V. , Pfeiffer Erin , Emerson Jillian A. , Amadi Florence Mariamu , Mitu Khadija , Corvalan Camila , Verdeli Helen , Araya Ricardo , Kadiyala Suneetha
Published: October 2021

Both malnutrition and poor mental health are leading sources of global mortality, disease, and disability. The fields of global food security and nutrition (FSN) and mental health have historically been seen as separate fields of research. Each have undergone substantial transformation, especially from clinical, primary care orientations to wider, sociopolitical approaches to achieve Sustainable Development Goals. In recent years, the trajectories of research on mental health and FSN are further evolving into an intersection of evidence. FSN impacts mental health through various pathways such as food insecurity and nutrients important for neurotransmission. Mental health drives FSN outcomes, for example through loss of motivation and caregiving capacities. They are also linked through a complex and interrelated set of determinants. However, the heterogeneity of the evidence base limits inferences about these important dynamics. Furthermore, interdisciplinary projects and programmes are gaining ground in methodology and impact, but further guidance in integration is much needed. An evidence-driven conceptual framework should inform hypothesis testing and programme implementation. The intersection of mental health and FSN can be an opportunity to invest holistically in advancing thinking in both fields.
Entropy-Driven Stochastic Federated Learning in Non-IID 6G Edge-RAN
Authors: Aamer Brahim , Chergui Hatim , Benjillali Mustapha , Verikoukis Christos
Published: October 2021

Scalable and sustainable AI-driven analytics are necessary to enable large-scale and heterogeneous service deployment in sixth-generation (6G) ultra-dense networks. This implies that the exchange of raw monitoring data should be minimized across the network by bringing the analysis functions closer to the data collection points. While federated learning (FL) is an efficient tool to implement such a decentralized strategy, real networks are generally characterized by time- and space-varying traffic patterns and channel conditions, making thereby the data collected in different points non independent and identically distributed (non-IID), which is challenging for FL. To sidestep this issue, we first introduce a new a priori metric that we call dataset entropy, whose role is to capture the distribution, the quantity of information, the unbalanced structure and the “non-IIDness” of a dataset independently of the models. This a priori entropy is calculated using a multi-dimensional spectral clustering scheme over both the features and the supervised output spaces, and is suitable for classification as well as regression tasks. The FL aggregation operations support system (OSS) server then uses the reported dataset entropies to devise 1) an entropy-based federated averaging scheme, and 2) a stochastic participant selection policy to significantly stabilize the training, minimize the convergence time, and reduce the corresponding computation cost. Numerical results are provided to show the superiority of these novel approaches.
Oral Health Advocacy Education Impacts Future Engagement: Exploration at a Midwestern US Dental School
Authors: Amini Homa , Wells Alexander J. , Boynton James R. , Guo Xiaohan , Ni Ai
Published: October 2021

Purpose:With the emergence of COVID-19, and the potential inclusion of dental benefits in Medicare, it is critical that dentists are able to engage in legislative advocacy to support public oral health. Dental education has an opportunity to teach advocacy skills to future dentists, although advocacy training in predoctoral dental education has been largely ignored. The purpose of this study was to evaluate fourth-year dental student's attitudes toward advocacy, identify the type and extent of advocacy experiences during dental school, and assess their future intentions to engage in advocacy.

Methods:An electronic questionnaire was administered to fourth-year dental students enrolled in their final semester at Ohio State University.

Results:Forty-seven students completed the survey (43% response rate). Most (84%) respondents agreed that advocacy training should be a required experience in accreditation standards for predoctoral dental education. Over half (58%) reported seldom or no exposure to legislative and regulatory processes in oral health policy development in the curriculum. Students who participated in grassroots advocacy efforts while in dental school were more likely to contact legislators regarding dental issues (p= 0.005) or public insurance (p= 0.037), and participate in future lobbying efforts (p= 0.019). Students who contributed to PAC while in dental school were more likely to express intentions to contribute in future (p= 0.005).

Conclusions:There is limited exposure to legislative advocacy in predoctoral dental education. Dental students with advocacy experience are more likely to report intentions to participate in advocacy as dentists. Dental education has a critical role in preparing future dentist-advocates.
Beyond the Binary: Sexual and Reproductive Health Considerations for Transgender and Gender Expansive Adolescents
Authors: Lunde Claire E. , Spigel Rebecca , Gordon Catherine M. , Sieberg Christine B.
Published: October 2021

Awareness and visibility of transgender individuals have grown exponentially. However, conceptualizing sexual and reproductive health (SRH) as “women's” or “men's” health services further marginalizes transgender and gender-expansive (TGE) youth. Multiple reviews and commentaries have been published on the topic of SRH care for adults under the umbrella term of sexual and gender minorities, all with a call to action for more inclusive care and the need for more clinical research involving TGE individuals, and notably, TGE youth. Results from adult TGE studies are often translated to describe adolescent models. However, models specific to adolescent TGE populations are needed to understand their unique SRH needs. This review will describe the current literature relating to SRH needs of TGE youth and adults, highlighting key areas with significant disparities in need of further research. This comprehensive summary will also provide recommendations for clinicians and researchers with the goal of improving SRH care and obtaining wider representation in both clinical settings and research directed toward TGE youth.
Characteristics of Culturable Microbial Community in Rhizosphere/Non-rhizosphere Soil of Potentilla Fruticosa Population in Alpine Meadow Elevation Gradient
Authors: Liu Minxia , Li Bowen , Xu Lu , Yu Ruixin
Published: October 2021

Potentilla fruticosa is a typical shrub of alpine meadows with canopy effects that can greatly influence soil fertility and microbiological parameters. Changes in rhizosphere microorganisms can reflect the response of these plants to environmental changes. This study aimed to examine the rhizosphere and non-rhizosphere of P. fruticosa on the amount of selected microorganisms and main environmental factors at different elevation gradients (3,000, 3,250, 3,500, 3,750, and 4,000 m). The results suggested that bacteria were predominant of the microbial soil community in the rhizosphere and non-rhizosphere, while fungi and actinomycetes represented the minority. With the increase of altitude, the total amount of microbial, bacteria, and actinomycetes in the rhizosphere and non-rhizosphere of P. fruticosa showed a downward trend, and microbial functional groups showed that the “hump shape” changed, but the fungi showed the opposite. Variance inflation factor (VIF) screening environmental factors and path analysis were obtained. In the rhizosphere soil, bacteria were affected by Soil organic carbon (SOC), and soil bulk density (SBD) became the main environmental limiting factor with the increase of altitude. The main environmental limiting factor of actinomycetes changed from SBD to Soil total (ST). In the non-rhizosphere soil, the bacteria and actinomycetes changed from ST to SOC and SBD, respectively. The main environmental limiting factor of the fungi was SOC in the rhizosphere and non-rhizosphere. Soil water content (SWC) was the main environmental determinant factor for all microbial groups, microbial functional groups were related to Soil total nitrogen (STN). Our results help to understand the relationship between nutrient cycling and the ecosystem function of alpine meadow plant soil microorganisms and provide theoretical support for alpine meadow ecosystem restoration, biodiversity protection, and the use of microbial resources.
A Learn-to-Rank Approach for Predicting Road Cycling Race Outcomes
Authors: Kholkine Leonid , Servotte Thomas , de Leeuw Arie-Willem , De Schepper Tom , Hellinckx Peter , Verdonck Tim , Latré Steven
Published: October 2021

Professional road cycling is a very competitive sport, and many factors influence the outcome of the race. These factors can be internal (e.g., psychological preparedness, physiological profile of the rider, and the preparedness or fitness of the rider) or external (e.g., the weather or strategy of the team) to the rider, or even completely unpredictable (e.g., crashes or mechanical failure). This variety makes perfectly predicting the outcome of a certain race an impossible task and the sport even more interesting. Nonetheless, before each race, journalists, ex-pro cyclists, websites and cycling fans try to predict the possible top 3, 5, or 10 riders. In this article, we use easily accessible data on road cycling from the past 20 years and the Machine Learning technique Learn-to-Rank (LtR) to predict the top 10 contenders for 1-day road cycling races. We accomplish this by mapping a relevancy weight to the finishing place in the first 10 positions. We assess the performance of this approach on 2018, 2019, and 2021 editions of six spring classic 1-day races. In the end, we compare the output of the framework with a mass fan prediction on the Normalized Discounted Cumulative Gain (NDCG) metric and the number of correct top 10 guesses. We found that our model, on average, has slightly higher performance on both metrics than the mass fan prediction. We also analyze which variables of our model have the most influence on the prediction of each race. This approach can give interesting insights to fans before a race but can also be helpful to sports coaches to predict how a rider might perform compared to other riders outside of the team.
A Living Income for Cocoa Producers in Côte d'Ivoire and Ghana?
Authors: van Vliet Jiska A. , Slingerland Maja A. , Waarts Yuca R. , Giller Ken E.
Published: October 2021

It is often claimed that cocoa producers are poor, but the extent of their poverty is rarely defined. We analyzed six data sets derived from household questionnaires of 385–88,896 cocoa producers in Côte d'Ivoire and Ghana. Across all data sets, many households (30–58%) earn a gross income below the World Bank extreme poverty line and the majority (73–90%) do not earn a Living Income. Households with less income per person per day generally achieve lower cocoa yields, consist of more household members, have a smaller land size available, and rely more on cocoa income than households with higher incomes. When comparing the effects of increasing prices and yields on gross income, yield increases lead to larger benefits especially for the poorest households. Doubling the cocoa price would leave 15–25% of households with a gross income below the extreme poverty line and 53–65% below the Living Income benchmark. At yields of 600 kg/ha, against current yields around 300 kg/ha, these percentages are reduced to 7–11 and 48–62%, respectively, while at yields of 1,500 kg/ha only 1–2% of households remain below the extreme poverty line and 13–20% below the Living Income benchmark. If we assume that the production costs of achieving a yield of 1,500 kg/ha are 30% of revenue, still only 2–4% of households earn a net income below the extreme poverty line and 25–32% below the Living Income benchmark. Whilst sustainable intensification of cocoa production is undoubtedly a strong approach to increase cocoa yields and farmer incomes, achieving this does not come without pitfalls. The poorer households face multiple barriers to invest in cocoa production. A better understanding of cocoa producing households and the resources available to them, as well as the opportunity for alternative income generation, is required to tailor options to increase their income. The utility and interpretability of future household surveys would be drastically improved if definitions and variables addressed were approached in a standardized way.
Anaesthesia in PROstate Biopsy Pain Obstruction Study: A Study Protocol for a Multicentre Randomised Controlled Study Evaluating the Efficacy of Perineal Nerve Block in Controlling Pain in Patients Undergoing Transperineal Prostate Biopsy
Authors: He Bi-Ming , Li Rong-Bing , Wang Hai-Feng
Published: October 2021

Introduction: Transperineal prostate biopsy is as effective as the transrectal biopsy in detecting prostate cancer and has a lower risk of infection. However, concerning the procedural pain of the transperineal route, a higher level of anaesthesia is needed, which prevents this approach from being widely used. Although several methods of local anaesthesia to relieve pain during transperineal biopsy have been described, few well-designed trials have been conducted to assess the efficacy of local anaesthesia.

Methods: This is a prospective, multicentre, randomised controlled study in men suspected of having prostate cancer and planning to undergo transperineal prostate biopsy. The aim of this trial is to determine whether the perineal nerve block and periprostatic block relieve pain to different extents in men undergoing transperineal biopsy. The main inclusion criteria are men aged between 18 and 80 years old, a prostate-specific antigen (PSA) level of 4–20 ng/ml, or/and suspicious rectal examination findings. A sample size of 190 participants, accounting for a 10% loss, is required. All participants will be randomly allocated at a ratio of 1:1 to the perineal nerve block (n = 95) and periprostatic block groups (n = 95). The primary outcome will be the level of the worst pain experienced during the transperineal prostate biopsy procedure, which will be measured by a numerical rating scale (NRS). The key secondary outcomes will include the pain severity score at 1, 6, and 24 h after prostate biopsy.

Results: The primary outcome is the level of the worst pain experienced during the prostate biopsy procedure. The main secondary outcomes are as follows: (1) Post-biopsy pain severity score at 1, 6, and 24 h after the prostate biopsy; (2) Changes in blood pressure, heart rate and breathing rate during the biopsy procedure; (3) External manifestations of pain during biopsy; (4) Anaesthesia satisfaction; (5) The detection rate for clinically significant prostate cancer and any prostate cancer.

Conclusion: Anaesthesia in PROstate biopsy Pain Obstruction Study (APROPOS) is randomised controlled trial aiming to determine the efficacy of the perineal nerve block in controlling pain in patients undergoing prostate biopsy via the transperineal approach.

Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT04501055.
Robot-Assisted Middle Ear Endoscopic Surgery: Preliminary Results on 37 Patients
Authors: Veleur Marine , Lahlou Ghizlene , Torres Renato , Daoudi Hannah , Mosnier Isabelle , Ferrary Evelyne , Sterkers Olivier , Nguyen Yann
Published: October 2021

Background: Endoscopy during middle ear surgery is advantageous for better exploration of middle ear structures. However, using an endoscope has some weaknesses as surgical gestures are performed with one hand. This may trouble surgeons accustomed to using two-handed surgery, and may affect accuracy. A robot-based holder may combine the benefits from endoscopic exposure with a two-handed technique. The purpose of this study was to assess the safety and value of an endoscope held by a teleoperated system.

Patients and Methods: A case series of 37 consecutive patients operated using endoscopic exposure with robot-based assistance was analyzed retrospectively. The RobOtol® system (Collin, France) was teleoperated as an endoscope holder in combination with a microscope. The following data were collected: patient characteristics, etiology, procedure type, complications, mean air and bone conduction thresholds, and speech performance at 3 months postoperatively. Patients had type I (myringoplasty), II (partial ossiculoplasty), and III (total ossiculoplasty) tympanoplasties in 15, 14, and 4 cases, respectively. Three patients had partial petrosectomies for cholesteatomas extending to the petrous apex. Finally, one case underwent resection of a tympanic paraganglioma. Ambulatory procedures were performed in 25 of the 37 patients (68%).

Results: Complete healing with no perforation of the tympanic membrane was noted postoperatively in all patients. No complications relating to robotic manipulation occurred during surgery or postoperatively. The mean air conduction gain was 3.8 ± 12.6 dB for type I (n = 15), 7.9 ± 11.4 dB for type II (n = 14), and −0.9 ± 10.8 for type III tympanoplasties (n = 4), and the postoperative air-bone conduction gap was 13.8 ± 13.3 dB for type I, 19.7 ± 11.7 dB for type II and 31.6 ± 13.0 dB for type III tympanoplasty. They was no relapse of cholesteatoma or paraganglioma during the short follow-up period (<1 year).

Conclusion: This study indicates that robot-assisted endoscopy is a safe and trustworthy tool for several categories of middle ear procedures. It combines the benefits of endoscopic exposure with a two-handed technique in middle ear surgery. It can be used as a standalone tool for pathology limited to the middle ear cleft or in combination with a microscope in lesions extending to the mastoid or petrous apex.
MÓZGOWE PODŁOŻE ROZWOJU MOWY W AUTYZMIE
Authors: Rymarczyk Krystyna
Published: October 2021

Although in a majority of cases, autistic children face difficulties
communicating verbally, the valid diagnostic classifi cations do not identify them
as the main symptoms of the disorder. The adoption of such a position has been
supported by results of (mainly behavioural) research, which imply that language
and speech development in the autism spectrum disorder (ASD) is extremely
variable and individually diversifi ed and the observed delay of its development is
not unique to autism. On the other hand, the research conducted by means of
neuroimaging methods shows that an atypical structure and activity of Broca’s
and Wernicke’s areas, which are important for language processes, exist in the
ASD. A weak structural and functional connectivity in the arcuate fasciculus,
which connects these structures, has also been discovered. It is assumed
that the changes arise from neurodevelopmental irregularities occurring at
an early stage of foetal life and their causes are probably genetic. This study
characterises speech development disorders and atypical brain development in
autism referring to results of both behavioural and neuroimaging research.