bluuebunny/crossref_metadata_2025 huggingface dataset:
Peningkatan Motivasi dan Pemahaman Siswa Kelas IV Dalam Pembuatan Animasi Stop Motion Sederhana Di SD Negeri Gayamsari 01 Semarang
Authors: Yanuarsari Dzuha Hening , Kadiasti Ristia , Rahmasari Erisa Adyati
Published: June 2023

Kreativitas teknik pengajaran memberikan dampak yang cukup signifikan bagi motivasi belajar.  Sekolah yang menjadi tempat dalam pengabdian masyarakat ini yakni Sekolah Dasar Negeri  Gayamsari 01 Semarang, di mana dalam kegiatan tersebut kita memberikan semacam pelatihan kepada murid-murid terkait materi desain dan animasi.  Persoalan yang ditemukan dalam penentuan tema materi tersebut adalah pada mata pelajaran Project yang ada di kelas 4 SD dimana pada mata pelajaran tersebut guru bisa mengembangkan materi yang diberikan dengan lebih menarik dan efektif. Setelah dilakukan inisiasi permasalahan dan kebutuhan dalam kegiatan pengabdian masyarakat diperoleh hasil diskusi yakni mengembangkan materi pembelajaran yang ada pada mata pelajaran Project.  Pendampingan langsung dengan bahan ajar berupa desain dan animasi menjadi alternatif pembelajaran yang menarik untuk menumbuhkan motivasi belajar peserta didik.  Observasi kebutuhan Mitra pada tahap awal diperoleh informasi bahwa mata pelajaran Project perlu diberikan materi yang lebih menumbuhkan minat belajar siswa sehingga capaian pembelajaran dapat tercapai.  Bahan ajar yang disampaikan pada pelatihan berupa desain karakter dan animasi sederhana atau animasi stop motion di mana peserta didik dapat mempraktekkan secara langsung teori terkait desain dan bagaimana menjalankan animasi sederhana. Hasil pelatihan ini berupa peningkatan pengetahuan peserta atau siswa-siswi mengenai materi seputar desain karakter dan  menjalankan animasi sederhana yakni animasi stop motion.
Expladish: Mengajar Bahasa Inggris Anak-anak melalui Program Community Service oleh Siswa Kelas XI SMAN Sumatera Selatan
Authors: Mareta Yoan , Dapala Zelka
Published: June 2023

Kedudukan Bahasa Inggris yang bukan merupakan bahasa sehari-hari pada masyarakat kita membuat siswa Sekolah Dasar kesulitan dalam mengembangkan skillnya. Anak yang berasal dari keluarga pra-sejahtera memiliki kendala ekonomi untuk mengikuti kursus yang berbayar. Maka dari itu melalui program Community Service yang rutin dilaksanakan satu tahun sekali, siswa kelas XI SMAN Sumatera Selatan yang tergabung dalam kelompok 1 memilih tema berjudul Expladish (explore, play, and study english). Kegiatan ini memberikan kesempatan kepada anak-anak untuk belajar lebih lanjut mengenai Bahasa Inggris. Metode yang digunakan dalam penelitian ini adalah Participatory Action Research (PAR) yang diartikan sebagai pendekatan penelitian yang mendorong pihak-pihak yang terkait dalam berkomitmen untuk menghasilkan perubahan sosial yang dilakukan melalui pemberdayaan dengan masyarakat. Hasil yang didapat dari program ini antara lain: 1) Munculnya kesadaran dalam diri anak-anak untuk lebih mengeksplorasi kemampuan berbahasa Inggris, 2) Bertambahnya pengetahuan seperti pengayaan vocabulary, 3) Meningkatnya kemampuan untuk merangkai kata dalam bahasa Inggris. Program pengabdian kepada masyarakat ini sangat penting untuk dilaksanakan secara rutin karena dapat meningkatkan daya dukung anak pada rentang usia 6-12 tahun untuk melanjutkan ke jenjang pendidikan yang lebih tinggi dan mampu bersaing dalam pendidikan di era modern.
Pelatihan Bahasa Inggris bagi Pekerja Migran Indonesia Kategori Pemula
Authors: Nernere Maria Setyaningsih , Astuti Vita , Kristianto Ignatius Indra
Published: June 2023

Pelaksanaan program pelatihan Bahasa Inggris bagi pekerja migran Indonesia di level pemula ini dilatarbelakangi oleh kebutuhan mitra. Kerjasama dengan IDN Global, pelatihan ini berfokus pada kemampuan Bahasa Inggris di level dasar. Koordinasi antara tutor, pihak IDN Global dan tim PkM hanya melalui media daring, tapi luaran yang dihasilkan dapat dirancang dan diaplikasikan dengan baik. Hal ini terukur respon positif para pekerja migran Indonesia yang menjadi peserta pelatihan yang terdokumentasi di form evaluasi kegiatan. Para pekerja migran didukung untuk semakin meningkatkan kompetensi Bahasa Inggrisnya sebagai nilai tambah mereka agar dapat bersaing dalam dunia kerja di luar Indonesia dan mewujudkan citra PMI yang berkualitas. Topik Batch IV tentang Kesehatan menjadi sangat relevan di masa pandemi dan menjadi wadah komunikasi yang baik antar para pekerja migran di perantauan. Berakhirnya program pengabdian ini menjadi awal kerja sama UAJY dan IDN Global untuk mengembangkan kemampuan Bahasa Inggris mereka dalam topik pembelajaran lainnya.
Edukasi Literasi Media untuk Pencegahan Perilaku Merokok bagi Guru di Desa Pendadaran Kabupaten Grobogan
Authors: Nurjanah - , Manglapy Yusthin Meriantty , Pradana PH Firmansyah Kholiq , Belladiena Alfiena Nisa
Published: June 2023

Dengan lemahnya regulasi di Indonesia mengenai pengendalian tembakau, terutama masifnya iklan promosi dan pronsor rokok (IPRS) diperlukan upaya untuk membentengi siswa SD untuk mencegah supaya tidak menjadi perokok. Guru berperan penting dalam penyalur edukasi terkait media literacy untuk pencegahan perilaku merokok. Tujuan kegiatan pengabdian ini adalah guru terampil melakukan edukasi mengenai Media Literacy untuk Pencegahan Perilaku Merokok Pada Siswa SD. Dalam ini, para peserta diberikan materi media literacy untuk pencegahan perilaku merokok pada anak dengan menggunakan lima video animasi dan buku bergambar. Hasil pre-test dan post test pada guru tentang media literacy dan sikap terhadap rokok diperoleh hasil bahwa ada rata-rata peningkatan media literacy dari nilai 68 menjadi 74 serta ada peningkatan sikap untuk tidak merokok dari 82 menjadi 83. Namun demikian peningkatan nilai tersebut tidak signifikan. Guru berkomitmen untuk menggunakan media pendidikan berupa video dan buku bergambar kepada siswa. Perlu ada evaluasi tindak lanjut guru dalam melaksanakan edukasi pencegahan perilaku merokok pada siswa. Tindak lanjut ini dapat dievaluasi dengan menanyakan kepada guru apakah sudah melakukan edukasi dengan media yang diberikan dan apakah diperlukan modifikasi dalam pelaksanaannya.
Pembinaan Peningkatan Kapasitas Usaha di UMKM Alenk Jaya Desa Galengdowo
Authors: Warmasuta I Made Mahotama , Sari Verawati Puspita
Published: June 2023

UMKM Alenk Jaya merupakan bentuk usaha yang berfokus pada produksi minuman herbal tradisional berupa jamu herbal yang terletak di Kecamatan Wonosalam, Kabupaten Jombang. Desa Galengdowo.Masih belum teraturnya segi operasional usaha menjadi kendala besar bagi Ibu Rinda pemilik dari UMKM Alenk Jaya. Pemasaran produk yang dilakukan juga belum mampu mencukupi kebutuhan usaha yang ideal. Sebagai solusinya, Diciptakan program Juragan Desa untuk membantu UMKM meningkatkan kapasitas usaha dan pendapatan mereka. Kegiatan pendampingan membahas solusi permasalahan UMKM seperti kemitraan, manajemen penjualan, optimalisasi keuntungan dan sistem operasi yang efisien. Mitra dapat meningkatkan konsistensi dan kapasitas produksi.
Pelatihan & Penerapan ISSN Pada Jurnal di SMA Negeri 3 Semarang
Authors: Haryanto Hanny , Gamayanto Indra , Wibowo Sasono , Budi Setyo , Maulana Herman Try , Haksoro Elok Iedfitra , Novianto Sendi
Published: June 2023

Penelitian merupakan hal yang sangat penting dalam mengembangkan inovasi. Oleh karena itu, tanpa penelitian maka tidak aka nada inovasi yang sesungguhnya. Pada pengabdian masyarakat ini kami mengadakan pelatihan penelitian dan juga bagaimana cara mengurus ISSN di jurnal yang sudah dimiliki oleh SMA Negeri 3, Semarang. Hal ini sangat penting karena merupakan sebuah kelanjutan untuk pengabdian masyarakat berikutnya. Hasil dari pengabdian masyarakat ini adalah SMA Negeri 3, Semarang terutama jurnal yang sudah dimilikinya akan memiliki dasar yang kuat, sehingga penelitian-penelitian tersebut dapat dipublikasikan secara rutin dan dapat memberikan dampak positif bagi masyarakat serta menghasilkan kontribusi yang baik bagi penelitian-penelitian yang aplikatif dan dapat diterapkan. Tentunya, pengabdian masyarakat ini akan terus dilanjutkan terutama dalam bidang pengembangkan dan kajian riset untuk siswa dan siswi di SMA Negeri 3, Semarang, sehingga dapat menghasilkan sumber daya manusia yang memiliki kompetensi tinggi dalam menghadapi globalisasi yang berlangsung dengan sangat cepat.
Peningkatan Kemampuan Berbahasa Asing Guna Kemajuan Desa Wisata Tempur
Authors: Asmarani Rahmanti , Sri Oemiati
Published: June 2023

Tempur sebagai salah satu desa di kecamatan Keling yang berbatasan dengan desa Kunir dan Damarwulan di sebelah utara, kota Kudus di sebelah selatan, di sebelah barat berbatasan dengan desa Sumanding dan Dudakawu serta berbatasan dengan kabupaten Pati di sebelah timur, selain memiliki panorama yang indah juga merupakan desa yang memiliki tempat-tempat yang sangat layak untuk dijadikan destinasi wisata bagi para wisatawan baik dalam maupun luar negeri. Di antaranya yaitu Candi Angin, Candi Bubrah, Sumur Batu, Kaldera Gunung Muria, Kolam Nawangwulan, Kolam Pemancingan Tempoera, Taman Hias, Bumi Perkemahan dan Wisata Kebun Kopi. Dengan adanya tempat-tempat yang sangat layak untuk dijadikan destinasi wisata tersebut tentu saja diperlukan kemampuan di kalangan anggota masyarakat wilayah desa Tempur untuk mampu mengelola dengan baik sehingga nantinya dapat meningkatkan jumlah wisatawan yang berkunjung ke desa Tempur. Untuk itu diperlukan kegiatan pendampingan yang dapat membantu kelompok masyarakat desa Tempur meningkatkan profesionalitas mereka dalam meningkatkan kemampuan kepariwisataan dan mengelola daerahnya. Kegiatan ini diharapkan dapat meningkatkan profesionalitas masyarakat desa Tempur kecamatan Keling Jepara dengan cara memberikan pendampingan, pembimbingan dan pelatihan dalam berbagai bidang kepariwisataan khususnya pelatihan dan pengenalan Bahasa dan budaya asing.
Edukasi Komposisi Desain dan Konten Iklan Bagi UMKM Lumintu
Authors: Haryadi Toto , Rahmasari Erisa Adyati , Yogananti Auria Farantika
Published: June 2023

Kondisi yang sudah terkendali pasca pandemi Covid-19 menjadi pemacu UMKM untuk berbenah diri agar bisa bertahan dan berkembang. Masing – masing melakukan berbagai upaya untuk mempromosikan produk secara lebih masif. Hal ini sebagaimana juga dilakukan oleh UMKM Lumintu yang berdiri sejak tahun 2020 dan terus berkembang secara positif. Meskipun bisa bertahan dan menjual produk, faktanya UMKM Lumintu masih kesulitan mempromosikan usaha secara online. Saat ini strategi promosi yang dilakukan masih konvensional yakni menawarkan produk dari mulut ke mulut dan ditawarkan dalam lingkup yang masih terbatas. Di sisi lain, semakin pesatnya penggunaan internet dan media sosial mendorong UMKM harus meningkatkan kemampuan dalam mengiklankan produknya secara lebih komunikatif dan menarik. Berdasarkan permasalahan tersebut diperlukan pelatihan edukasi komposisi desain dan konten iklan bagi UMKM Lumintu sebagai langkah awal untuk membuat iklan secara mandiri yang memanfaatkan aset hasil sendiri melalui pemanfaatan aplikasi Canva dan perangkat smartphone yang telah dimiliki. Hasil kegiatan ini yaitu desain media iklan sederhana yang bisa dirancang dimanapun, kapanpun, dan oleh siapapun karena mudah diterapkan dan hasilnya bisa diunggah menjadi konten story whatsapp, feed instagram, hingga status facebook. Kegiatan ini bisa dilanjutkan untuk lebih memaksimalkan peran aktif pelaku UMKM dalam mempromosikan produk melalui iklan yang bisa dirancang sendiri (doi t yourself).
Penerapan E-commerce dan Media Sosial dalam Meningkatkan Pemasaran Produk Wirausaha Panti Asuhan Abdul Kadir Kurnia
Authors: Abdullah Moch. Zawaruddin , Rahmad Cahya , Ariyanto Rudy , Kirana Annisa Puspa , Sukmana Septian Enggar
Published: June 2023

Panti Asuhan Yatim Abdul Kadir Kurnia merupakan salah satu lembaga panti asuhan yang terletak di Kota Malang. Panti asuhan ini memiliki program kegiatan usaha untuk memberikan bekal keterampilan pada anak asuh serta menambah sumber pendanaan lembaga. Namun, kegiatan usaha yang dilakukan oleh Pondok Anak Yatim Abdul Kadir Kurnia ini kurang maksimal dalam segi penjualan. Faktor kurang maksimalnya penjualan ini dikarenakan produk-produk karya panti tidak terpasarkan dengan baik. Perlu pemahaman tentang pengelolaan pemasaran secara online secara digital marketing seperti sosial media atau web e-commerce, sehingga produk yang telah dibuat dikenal masyarakat luas. Kegiatan pengabdian masyarakat yang diusulkan ini berinisiatif untuk menerapkan dan memanfaatkan website e-commerce  dan sosial media guna mengenalkan produk-produk karya kegiatan usaha dari panti asuhan Abdul Kadir Kurnia  ke khalayak publik.
Pembekalan Branding Industri dengan Pemanfatan Teknik Logo sebagai Media Promosi Produk UMKM Kelurahan Tanjung Mas Semarang
Authors: P Elkaf Rahmawan , Muslih - , Prabowo Abi Seno , Khamadi - , Soeleman Arief
Published: June 2023

Perempuan merupakan makhluk yang diciptakan dengan berbagai kelebihan sehingga banyak hal yang dapat dilakukan perempuan. Perempuan juga dapat berperan aktif dalam membantu pendapatan ekonomi keluarga apabila pendapatan keluarga dirasa masih kurang atau pas-pasan. Kelurahan Tanjung Emas merupakan salah satu daerah kumuh yang ada di Kota Semarang. Permukiman yang berkembang di Kawasan Kelurahan Tanjung Emas yaitu permukiman nelayan dan permukiman padat kota dengan mata pencaharian utama penduduk bekerja di sektor informal. Dengan kebanyakan penduduk bekerja di sektor informal menimbulkan masalah pada keluarga karena mendapatkan penghasilan yang tidak menentu. Sesuai dengan peranan perempuan dalam era sekarang, maka perempuan seharusnya memiliki peran pemberdayaan dalam keluarga. Salah satu lembaga swadaya masyarakat yang fokus terhadap pemberdayaan perempuan dan perlindungan anak adalah Yayasan Anantaka. Khusus dalam hal pemberdayaan perempuan, Yayasan Anantaka berfokus pada mendukung perempuan berwirausaha sebagai tenaga kerja mandiri. Kegiatan yang dilakukan salah satunya adalah pendampingan pelatihan kewirausahaan. Keberhasilan kegiatan pemberdayaan perempuan yang dilakukan dalam hal pendampingan pelatihan kewirausahaan di kecamatan Gunung Pati akan dilanjutkan di Kelurahan Tanjung Emas. Permasalahan angka tingkat kemiskinan di Kelurahan Tanjung Emas seharusnya dapat berkurang dengan peran serta perempuran sebagai bagian dari keluarga. Ibu-ibu di Kelurahan Tanjung Emas sudah mendapatkan pelatihan tentang pengolahan boga dan makanan sehat. Pelatihan tersebut telah melahirkan banyak olahan makanan yang sebenarnya dapat dipasarkan ke luar Kelurahan Tanjung Emas. Akan tetapi, produk makanan yang dihasilkan belum dibranding dengan baik sehingga tidak dapat dimanfaatkan potensi ekonominya dengan baik.
Practical ultrasonography in hands of clinician
Authors: Lykhin V. N. , Bushuev V. O. , Filyavin R. E. , Gombozhapov B. G. , Tsydenova A. Yu. , Bubaev I. A. , Sidenov O. I. , Zhamsoeva I. B.
Published: June 2023

Point-of-Care Ultrasound is a complex of diagnostic ultrasound methods with ultrasound guided interventions. The main difference from the classical use of ultrasound is the use of ultrasound by doctors of various specialties (anesthesiologists, intensive care, surgeons, obstetriciansgynecologists, etc.) to answer diagnostic questions that arise from a clinician when working with patients. The article presents the Russian experience of successful implementation of the method of focused ultrasound-assisted examination (manipulation) in the clinical practice of physicians of various specialties on the example of several medical institutions of Buryatia Region.
Creep-damage modelling for micro gas turbine combustion chambers lifetime prediction
Authors: Cirigliano Daniele , D'Souza Herol Lawerence , Grimm Felix , Kutne Peter , Aigner Manfred
Published: June 2023

Micro Gas Turbines (MGTs) are nowadays largely used for electrical and thermal energy production in small buildings and households. Their reliability and compactness allow them to operate for thousands of hours with minimal maintenance. However, the long exposure at high temperatures in combustion chambers can promote creep, which can induce thermal fatigue and potential failure of these components. Creep-induced damage in MGTs has not yet been thoroughly investigated, due to the lack of numerical tools able to model these strongly coupled phenomena. This study presents the development of a Fortran-based subroutine integrated into ANSYS APDL. The code allows for a life assessment based on the Lemaitre-Chaboche creep damage model. Secondary creep and stress relaxation are modeled for the high-temperature resistant alloy Inconel718. A new set of temperature-dependent parameters for the Norton equation is provided, and the method to obtain these parameters from creep rupture tests is outlined. The model is validated and shows good agreement with experimental data. The subroutine correctly reproduces visco-plasticity, stress relaxation and damage under typical MGTs operating temperatures. This model constitutes the foundation of a life-assessment analysis for combustion chambers. The results highlight the impact of temperature and creep on the component’s life and the importance of integrating life assessment analysis into the preliminary design of combustion chambers.
PACT Tropical Moist Forest Accreditation Methodology
Authors: Balmford Andrew , Coomes David , Hartup James , Jaffer Sadiq , Keshav Srinivasan , Lam Miranda , Madhavapeddy Anil , Rau E-Ping , Swinfield Thomas , Wheeler Charlotte
Published: June 2023

This draft document describes the methodology developed by the Cambridge Center for Carbon Credits (4C) for estimating the number of credits to be issued to a project in the tropical moist forest (TMF) biome. It expands on the methodology outlined in (Swinfield and Balmford, 2023). We welcome comments and suggestions in the associated online document at https://tinyurl.com/cowgreport.
Related Reviews: Multiband Planar Inverted Antenna for Mobile Communication
Authors: Ma'rifah Puteri Nurul , Rohadi Erfan , Siradjuddin Indrazno , Junus Mochammad
Published: June 2023

Research in the field of planar inverted antennas with multiband frequencies is currently being developed. Due to the hugely increased number of mobile users, at least every time a new generation is released, a mobile communication system is released with additional features. All additional features of a mobile communication system require an antenna that resonates over a specific frequency spectrum range, meaning multiple antennas are required in a single mobile device to function across all generations for all frequency spectrums. To reduce the number of antennas on a mobile communication system device, it is necessary to design a new type of antenna that operates in a different frequency range. The inverted planar multiband antenna is designed to have changing sizes, shapes, and material properties. Types of inverted planar antennas include planar inverted-L antennas (PILA) and planar inverted-F antennas (PIFA). After analysis, the antenna designed by Juan Zhang et al. is the best solution for mobile communication systems. The designed antenna has compact antenna dimensions and four frequency bands that can be applied to N1/N78/N79 5G and 5.8 GHz WLAN. The antenna has a high gain of almost 5dB in the 5.60–7.00 GHz frequency range. They also claim that the antenna has a beam efficiency of four very high-frequency antenna points and a small side lobe that appears only at the top at the highest frequency point. But unfortunately, the antenna cannot cover the entire frequency range that must exist in a mobile communication system
Battery Charging Control Using Photovoltaic with Sepic Converter
Authors: Ika Putri Ratna , Nata Surya , Priyadi Bambang
Published: June 2023

This article presents a battery charging design using photovoltaic with a septic converter. The use of batteries as energy storage is one way to ensure the availability of energy to the load and overcome the weaknesses of photovoltaic systems which depend on solar irradiation and temperature. when the solar irradiation is low, the battery can supply energy to the load. SEPIC converter is used to adjust the battery charging voltage requirements. The output voltage of the SEPIC converter is maintained constant by setting the duty cycle using a microcontroller. Based on the results of experimental testing, this PV system with a SEPIC converter can work well. Battery charging can be done optimally. This system is also equipped with automatic disconnection of the battery if the battery is fully charged so that the lifetime of the battery is maintained
The Pipeline for Publishing Resources in the Language Bank of Finland
Authors: Dieckmann Ute , Lennes Mietta , Piitulainen Jussi , Niemi Jyrki , Axelson Erik , Jauhiainen Tommi , Lindén Krister
Published: June 2023

We present the process of publishing resources in Kielipankki, the Language Bank of Finland. Our pipeline includes all the steps that are needed to publish a resource: from finding and receiving the original data until making the data available via different platforms, e.g., the Korp concordance tool or the download service. Our goal is to standardize the publishing process by creating an ordered checklist of tasks with the corresponding documentation and by developing conversion scripts and processing tools that can be shared and applied on different resources.
Neural Metaphor Detection for Slovene
Authors: Klemen Matej , Robnik-Šikonja Marko
Published: June 2023

Metaphors are linguistic expressions using comparison with another concept to potentially improve the language expressivity. Due to relevant downstream applications, metaphor detection is an active topic of research. Most of the research is focused on English, while other languages are less covered. In our work, we focus on Slovene, presenting the first word-level metaphor detection experiments. We apply multiple transformer-based large language models on four versions of two publicly available Slovene corpora: KOMET and G-KOMET. We perform monolingual, multilingual, and cross-lingual experiments, using the VU Amsterdam metaphor corpus as an additional source of metaphor knowledge. We evaluate the models quantitatively using word-level $F_1$ score and find that (1) the most consistently well-performed model is the trilingual CroSloEngual BERT model, (2) the addition of English data in multilingual experiments does not improve the performance significantly, and (3) the cross-lingual models achieve significantly worse results than their monolingual and multilingual counterparts.
Evaluation of the Archivio Vi.Vo Architecture: A Case Study on the Reuse of Legacy Data for Linguistic Purposes
Authors: Luzietti Roberta Bianca
Published: June 2023

The object of this paper is the validation of the Archivio Vi.Vo. architecture, developed within the CLARIN-IT consortium for the preservation and accessible consultation of historical oral archives. Following the first case study employing the Caterina Bueno archive, the goal is to now show how this innovative architecture is also suitable for conducting research investigations on the archival data and hosting different types of archives. The real use case study presented in this contribution, aims at employing the Angela Spinelli archive for conducting a sociophonetic investigation on Tuscan vernacular.
HINTS: Human-Centered Intelligent Realities
Authors: Sundstedt Veronica , Boeva Veselka , Zepernick Hans-Jürgen , Goswami Prashant , Cheddad Abbas , Tutschku Kurt , Grahn Håkan , Casalicchio Emiliano , Fiedler Markus , Mendes Emilia , Abghari Shahrooz , Hu Yan , Garro Valeria , Chu Thi My Chinh , Lundberg Lars , Arlos Patrik
Published: June 2023

During the last decade, we have witnessed a rapid development of extended reality (XR) technologies such as augmented reality (AR) and virtual reality (VR). Further, there have been tremendous advancements in artificial intelligence (AI) and machine learning (ML). These two trends will have a significant impact on future digital societies. The vision of an immersive, ubiquitous, and intelligent virtual space opens up new opportunities for creating an enhanced digital world in which the users are at the center of the development process, so-called intelligent realities (IRs). The “Human-Centered Intelligent Realities” (HINTS) profile project will develop concepts, principles, methods, algorithms, and tools for human-centered IRs, thus leading the way for future immersive, user-aware, and intelligent interactive digital environments. The HINTS project is centered around an ecosystem combining XR and communication paradigms to form novel intelligent digital systems. HINTS will provide users with new ways to understand, collaborate with, and control digital systems. These novel ways will be based on visual and data-driven platforms which enable tangible, immersive cognitive interactions within real and virtual realities. Thus, exploiting digital systems in a more efficient, effective, engaging, and resource-aware condition. Moreover, the systems will be equipped with cognitive features based on AI and ML, which allow users to engage with digital realities and data in novel forms. This paper describes the HINTS profile project and its initial results.
Algaeculture for agriculture: from past to future
Authors: Ferreira Alice , Bastos Carolina R. V. , Marques-dos-Santos Cláudia , Acién-Fernandez Francisco Gabriel , Gouveia Luisa
Published: June 2023

The continuous growth of the world population has imposed major challenges on agriculture. Consequently, farmers generalized the overuse of synthetic fertilizers and pesticides to meet the global food demand. Although these products have helped many developing countries increase their crop yield, they have simultaneously resulted in many issues, mainly the decline of soil fertility and degradation of local ecosystems due to soil, water, and air contamination, combined with their non-renewable nature and increased costs. For agriculture to become more sustainable, the use of alternative biological products, with recognized beneficial effects on plant yield and health, must be expanded. In this context, microalgae and cyanobacteria are rich sources of nutrients and bioactive metabolites, which have been gaining attention from researchers and companies for their ability to improve plant nutrition, growth, and tolerance to stress. This review gives an overview of the research work that has been done in the last two decades, regarding the use of microalgae and cyanobacteria (blue-green algae) as biofertilizers, biostimulants, and biopesticides. This work identified trends and challenges and highlights the use of microalgae to recycle the nutrients from wastewater to improve plant productivity while reducing the fertilizer and water footprint for more sustainable agriculture practices.
Application of the Five Domains model to food chain management of animal welfare: opportunities and constraints
Authors: Beausoleil N. J. , Swanson J. C. , McKeegan D. E. F. , Croney C. C.
Published: June 2023

For businesses involved in animal production, ensuring high animal welfare standards has become the cornerstone of corporate social responsibility practices. Since animal welfare cannot be verified by consumers at the point of purchase, industry-led audits provide important assurance that animals used to produce food lived an acceptable quality of life and experienced a humane death. The Five Freedoms offer a simple tool to conceptualize the complex, multi-dimensional concept of animal welfare, and they have been widely adopted as a basic operational framework for compliance. However, the Five Freedoms are problematic in that they focus on the absence of negative welfare states, underemphasize the importance of positive experiences, are absolute, and represent a (mostly unattainable) ideal. The Five Domains model represents inter-related aspects of an animal’s welfare state, with four physical/functional domains used to infer likely mental experiences in the fifth domain. This model allows for consideration of both positive and negative affective experiences, recognizes degrees of welfare compromise, acknowledges that animals cannot be free from all negative experiences (and that indeed, some are essential for survival). Thus, the model better reflects current scientific understanding of animal welfare and – that ultimately, we are interested in how animals experience their lives. Nevertheless, caution is needed when inferring mental states, which can never be directly observed or measured, and hence the ultimate outcomes of the model’s application should be qualitative. Operationalization of the Five Domains offers several opportunities to improve the breadth and quality of welfare audits for production animals. The model can incorporate both resource/management- based and animal-based measures of welfare; the former reflect risks to animals’ welfare while the latter often provide direct information on the animal’s welfare state at the time of assessment. Existing welfare indicators may be linked to relevant mental states and evaluated accordingly, and new metrics may be scientifically identified. Importantly, the Five Domains structure demands scrutiny of the affective state consequences to animals of housing, handling, and husbandry procedures, and could improve the effectiveness of animal welfare training for auditors and stockpersons. Adoption of the Five Domains framework could facilitate improved communication about animal welfare in the food chain with customers and consumers.
Application of tumor pH/hypoxia-responsive nanoparticles for combined photodynamic therapy and hypoxia-activated chemotherapy
Authors: Zhang Zhang , Feng Jintang , Zhang Tianzhu , Gao An , Sun Chunyang
Published: June 2023

Introduction: Cancer selectivity, including targeted internalization and accelerated drug release in tumor cells, remains a major challenge for designing novel stimuli-responsive nanocarriers to promote therapeutic efficacy. The hypoxic microenvironment created by photodynamic therapy (PDT) is believed to play a critical role in chemoresistance.

Methods: We construct dual-responsive carriers (DANPCT) that encapsulate the photosensitizer chlorin e6 (Ce6) and hypoxia-activated prodrug tirapazamine (TPZ) to enable efficient PDT and PDT-boosted hypoxia-activated chemotherapy.

Results and discussion: Due to TAT masking, DANPCT prolonged payload circulation in the bloodstream, and selective tumor cell uptake occurred via acidity-triggered TAT presentation. PDT was performed with a spatially controlled 660-nm laser to enable precise cell killing and exacerbate hypoxia. Hypoxia-responsive conversion of the hydrophobic NI moiety led to the disassembly of DANPCT, facilitating TPZ release. TPZ was reduced to cytotoxic radicals under hypoxic conditions, contributing to the chemotherapeutic cascade. This work offers a sophisticated strategy for programmed chemo-PDT.
PPGFeat: a novel MATLAB toolbox for extracting PPG fiducial points
Authors: Abdullah Saad , Hafid Abdelakram , Folke Mia , Lindén Maria , Kristoffersson Annica
Published: June 2023

Photoplethysmography is a non-invasive technique used for measuring several vital signs and for the identification of individuals with an increased disease risk. Its principle of work is based on detecting changes in blood volume in the microvasculature of the skin through the absorption of light. The extraction of relevant features from the photoplethysmography signal for estimating certain physiological parameters is a challenging task, where various feature extraction methods have been proposed in the literature. In this work, we present PPGFeat, a novel MATLAB toolbox supporting the analysis of raw photoplethysmography waveform data. PPGFeat allows for the application of various preprocessing techniques, such as filtering, smoothing, and removal of baseline drift; the calculation of photoplethysmography derivatives; and the implementation of algorithms for detecting and highlighting photoplethysmography fiducial points. PPGFeat includes a graphical user interface allowing users to perform various operations on photoplethysmography signals and to identify, and if required also adjust, the fiducial points. Evaluating the PPGFeat’s performance in identifying the fiducial points present in the publicly available PPG-BP dataset, resulted in an overall accuracy of 99% and 3038/3066 fiducial points were correctly identified. PPGFeat significantly reduces the risk of errors in identifying inaccurate fiducial points. Thereby, it is providing a valuable new resource for researchers for the analysis of photoplethysmography signals.
CARTIS: a method for the typological-structural characterization of Italian ordinary buildings in urban areas
Authors: Zuccaro Giulio , Dolce Mauro , Perelli Francesca Linda , De Gregorio Daniela , Speranza Elena
Published: June 2023

Large-scale risk assessments relevant to natural hazards are commonly based on very poor exposure and vulnerability data, often drawn from census data. In fact, obtaining a detailed knowledge of the built heritage is a very hard task especially for those countries, like Italy, characterized by very high urban density and large variety of building typologies, where a building-by-building knowledge can sound as a utopian ambition. Nevertheless, exposure and vulnerability are two of the four factors governing, along with hazard and capacity, risk convolution, and hence their uncertainties yield to corresponding uncertainties in the resulting expected losses. The lack of suitable information on building typologies is responsible of very strong simplifications in risk analyses, like the assumption of the same building typologies, indistinctly scattered all over the Country territory, without distinctions at a local or at a regional level. With the goal of improving exposure description and reducing such uncertainties, since 2014 the Italian Civil Protection Department (ICPD) has undertaken a new research branch in the framework of ReLUIS (Network of University Laboratories in Earthquake Engineering) projects, dedicated to territorial analyses, by funding also the CARTIS project. The project has the goal to characterize the building structural typologies trough a data collection at a local and an extensive scale in Italy, with the final aim to improve the reliability of seismic risk analyses. The paper describes the method and some first statistics so far elaborated.
The secretome of the fish pathogen Tenacibaculum maritimum includes soluble virulence-related proteins and outer membrane vesicles
Authors: Escribano M. Pilar , Balado Miguel , Toranzo Alicia E. , Lemos Manuel L. , Magariños Beatriz
Published: June 2023

Tenacibaculum maritimum, the etiological agent of tenacibaculosis in marine fish, constitutively secretes extracellular products (ECPs) in which protein content has not been yet comprehensively studied. In this work, the prevalence of extracellular proteolytic and lipolytic activities related to virulence was analyzed in 64 T. maritimum strains belonging to the O1–O4 serotypes. The results showed the existence of a great intra-specific heterogeneity in the enzymatic capacity, particularly within serotype O4. Thus, the secretome of a strain belonging to this serotype was characterized by analyzing the protein content of ECPs and the possible production of outer membrane vesicles (OMVs). Notably, the ECPs of T. maritimum SP9.1 contain a large amount of OMVs that were characterized by electron microscopy and purified. Thus, ECPs were divided into soluble (S-ECPs) and insoluble fractions (OMVs), and their protein content was analyzed by a high-throughput proteomic approach. A total of 641 proteins were identified in ECPs including some virulence-related factors, which were mainly found in one of the fractions, either OMVs or S-ECPs. Outer membrane proteins such as TonB-dependent siderophore transporters and the type IX secretion system (T9SS)-related proteins PorP, PorT, and SprA appeared to be mainly associated with OMVs. By contrast, putative virulence factors such as sialidase SiaA, chondroitinase CslA, sphingomyelinase Sph, ceramidase Cer, and collagenase Col were found only in the S-ECPs. These findings clearly demonstrate that T. maritimum releases, through surface blebbing, OMVs specifically enriched in TonB-dependent transporters and T9SS proteins. Interestingly, in vitro and in vivo assays also showed that OMVs could play a key role in virulence by promoting surface adhesion and biofilm formation and maximizing the cytotoxic effects of the ECPs. The characterization of T. maritimum secretome provides insights into ECP function and can constitute the basis for future studies aimed to elucidate the full role of OMVs in the pathogenesis of fish tenacibaculosis.
Coronary plaque burden predicts perioperative cardiovascular events after coronary endarterectomy
Authors: Gao Mingxin , Wen Wanwan , Gu Chengxiong , Zhang XiaoLi , Yu Yang , Li Haiyang
Published: June 2023

Background and aims

The risk factors of perioperative and long-term cardiovascular events in patients undergoing coronary artery bypass grafting (CABG) with adjunctive coronary endarterectomy (CE) are not well determined. This study evaluated the clinical value of coronary plaque burden, coronary anatomic stenosis, and serum biomarkers for predicting perioperative cardiovascular events after off-pump CABG + CE.

Methods

This retrospective cohort single-center study enrolled 125 patients undergoing off-pump CABG + CE between February 2018 and September 2021 in China. Coronary plaque burden was reflected by the length of plaque removed by CE. Plaque length-max, which represents the plaque length in patients undergoing single-vessel CE and the maximum plaque length in patients undergoing multivessel CE, was calculated. The primary endpoint was perioperative myocardial infraction (PMI).

Results

Plaque length-max was significantly higher in patients with PMI than in those without PMI (2.4 ± 1.5 vs. 1.6 ± 0.9, p = .001). A threshold plaque length-max of 1.15 cm was an independent predictor of PMI (area under the curve: 0.67; sensitivity 87.9%; specificity 59.8%; p = .005). Patients with plaque length-max ≥1.15 had a > 5-fold increase in PMI after adjusting for confounding factors (odds ratio = 5.89; p = .002). Furthermore, interleukin-6 (Beta = .32: p = .028), CD68 (Beta = .34; p = .045), and osteopontin (Beta = .43; p = .008) were significantly correlated with plaque length-max.

Conclusions

Plaque length-max was superior to clinical cardiovascular risk factors in predicting PMI occurrence after off-pump CABG + CE, which might be associated with systemic and plaque inflammation state.
On the relationship between the mechanical strength and mineral microstructure of biotite granite under temperature influence
Authors: Huang Yuyang , Li Tianbin
Published: June 2023

Many studies are currently focusing on the mechanical properties of granite from macroscopic and microscopic perspectives, but only several studies on the influence of rock mineral composition on the mechanical properties using a combined macro-micro assessment. The biotite granite in the Gaoligong Mountains was selected as the research object, and the variation strength characteristics at 20–130°C were obtained through uniaxial compression experiments. The rock’s uniaxial compressive strength and elastic modulus reached peak values at 40°C. The main mineral components of the rock determined by X-ray powder diffraction were quartz, biotite, albite, and potash feldspar. With Material Studio software, molecular dynamics simulations were carried out on the crystal models of quartz, biotite, albite, and potash feldspar at 20–130°C, and relevant mechanical parameters were calculated. The macroscopic and microscopic experimental data were compared and analyzed. The results show that: 1) due to the thermal expansion of minerals in the rock, the original cracks between particles are partially closed, and the sample strength is the largest at 40°C; 2) temperature mostly affects quartz and biotite phases, and the rock strength increases first and then decreases with the temperature increase. The mechanical properties of albite and potash feldspar are less affected by temperature; 3) macroscopic and microscopic experimental results show that the rock strength reaches the peak value in a certain temperature range. The obtained critical temperature is different because the rock sample also contains a small amount of argillaceous rock, siliceous rock, phyllite, and some siliceous and calcareous cement beside the main mineral composition; 4) The structural changes of quartz and biotite are affected by temperature. The bond length of the quartz crystal decreases while that of the biotite crystal first increases and then decreases with the temperature. The mechanism of the temperature influence on the increase of the rock strength is different for these two crystal phases, and it requires further exploration.
Identification of key immune genes of osteoporosis based on bioinformatics and machine learning
Authors: Hao Song , Xinqi Mao , Weicheng Xu , Shiwei Yang , Lumin Cao , Xiao Wang , Dong Liu , Jun Hua
Published: June 2023

Introduction

Immunity is involved in a variety of bone metabolic processes, especially osteoporosis. The aim of this study is to explore new bone immune-related markers by bioinformatics method and evaluate their ability to predict osteoporosis.

Methods

The mRNA expression profiles were obtained from GSE7158 in Gene expression Omnibus (GEO), and immune-related genes were obtained from ImmPort database (https://www.immport.org/shared/). immune genes related to bone mineral density(BMD) were screened out for differential analysis. protein-protein interaction (PPIs) networks were used to analyze the interrelationships between different immune-related genes (DIRGs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of DIRGs function were performed. A least absolute shrinkage and selection operation (LASSO) regression model and multiple Support Vector Machine-Recursive Feature Elimination (mSVM-RFE) model were constructed to identify the candidate genes for osteoporosis prediction The receiver operator characteristic (ROC) curves were used to validate the performances of predictive models and candidate genes in GEO database (GSE7158,GSE13850).Through the RT - qPCR verify the key genes differentially expressed in peripheral blood mononuclear cells Finally, we constructed a nomogram model for predicting osteoporosis based on five immune-related genes. CIBERSORT algorithm was used to calculate the relative proportion of 22 immune cells.

Results

A total of 1158 DEGs and 66 DIRGs were identified between high-BMD and low-BMD women. These DIRGs were mainly enriched in cytokine−mediated signaling pathway, positive regulation of response to external stimulus and the cellular components of genes are mostly localized to external side of plasma membrane. And the KEGG enrichment analysis were mainly involved in Cytokine−cytokine receptor interaction, PI3K−Akt signaling pathway, Neuroactive ligand−receptor interaction,Natural killer cell mediated cytotoxicity. Then five key genes (CCR5, IAPP, IFNA4, IGHV3-73 and PTGER1) were identified and used as features to construct a predictive prognostic model for osteoporosis using the GSE7158 dataset.

Conclusion

Immunity plays an important role in the development of osteoporosis.CCR5, IAPP, IFNA4, IGHV3-73 and PTGER1were play an important role in the occurrences and diagnosis of OP.
Habitual nappers and non-nappers differ in circadian rhythms of LIPE expression in abdominal adipose tissue explants
Authors: Zambrano Carolina , Kulyté Agné , Luján Juán , Rivero-Gutierrez Belén , Sánchez de Medina Fermín , Martínez-Augustin Olga , Ryden Mikael , Scheer Frank A. J. L. , Garaulet Marta
Published: June 2023

Background and purpose

Napping is a widespread practice worldwide and has in recent years been linked to increased abdominal adiposity. Lipase E or LIPE encodes the protein hormone-sensitive lipase (HSL), an enzyme that plays an important role in lipid mobilization and exhibits a circadian expression rhythm in human adipose tissue. We hypothesized that habitual napping may impact the circadian expression pattern of LIPE, which in turn may attenuate lipid mobilization and induce abdominal fat accumulation.

Methods

Abdominal adipose tissue explants from participants with obesity (n = 17) were cultured for a 24-h duration and analyzed every 4 h. Habitual nappers (n = 8) were selected to match non-nappers (n = 9) in age, sex, BMI, adiposity, and metabolic syndrome traits. Circadian LIPE expression rhythmicity was analyzed using the cosinor method.

Results

Adipose tissue explants exhibited robust circadian rhythms in LIPE expression in non-nappers. In contrast, nappers had a flattened rhythm. LIPE amplitude was decreased in nappers as compared with non-nappers (71% lower). The decrease in amplitude among nappers was related to the frequency of napping (times per week) where a lower rhythm amplitude was associated with a higher napping frequency (r = -0.80; P = 0.018). Confirmatory analyses in the activity of LIPE’s protein (i.e., HSL) also showed a significant rhythm in non-nappers, whereas significance in the activity of HSL was lost among nappers.

Conclusion

Our results suggest that nappers display dysregulated circadian LIPE expression as well as dysregulated circadian HSL activity, which may alter lipid mobilization and contribute to increased abdominal obesity in habitual nappers.
Waist-corrected BMI predicts incident diabetes mellitus in a population-based observational cohort study
Authors: Wang Nana , Li Yuying , Guo Chuanji
Published: June 2023

Introduction

Waist-corrected body mass index (wBMI), which combines BMI and waist circumference (WC) measurements, has proven superior to either measure alone for predicting obesity but has not yet been applied to the prediction of diabetes mellitus (DM).

Methods

Over a 5-year period, 305,499 subjects were eligible for this study based on citizen health check-ups in the Tacheng Area of northwest China. Diagnosis of DM was defined as the end point.

Results

After exclusion, a total of 111,851 subjects were included in the training cohort and 47,906 in the validation cohort. Participants of both sexes with wBMI in the upper quartiles had significantly higher incidence of DM than those with wBMI in the lower quartiles (log-rank χ2 = 236, p< 0.001 for men; log-rank χ2 = 304, p< 0.001 for women). After adjusting for multiple variables, WC, BMI, wBMI, and waist-to-height ratio (WHtR) were all independent predictors for diabetes. In men, the adjusted hazard ratios (HRs) of wBMI for diabetes for the second, third, and fourth quartiles were 1.297 [95% CI: 1.157, 1.455], 1.664 [95% CI: 1.493, 1.853], and 2.132 [95% CI: 1.921, 2.366], respectively, when compared with the first quartile. In women, they were 1.357 [95% CI: 1.191, 1.546], 1.715 [95% CI: 1.517, 1.939], and 2.262 [95% CI: 2.010, 2.545], respectively. Compared with WC, BMI, and WHtR, wBMI had the highest C-index in both men (0.679, 95% CI: 0.670, 0.688) and women (0.730, 95% CI: 0.722, 0.739). Finally, a nomogram was constructed to predict incident DM based on wBMI and other variables. In conclusion, wBMI had the strongest predictive capacity for incident DM when compared with WC, BMI, and WHtR, especially in women.

Discussion

This study provides a reference for advanced investigation of wBMI on DM and other metabolic diseases in the future.