bluuebunny/crossref_metadata_2025 huggingface dataset:
Prze-pisywanie. „Dziennik hipopotama” Krzysztofa Vargi jako strategia lektury
Authors: Regiewicz Adam
Published: April 2022

Celem artykułu jest wykazanie, że Dziennik hipopotama Krzysztofa Vargi to typowe dzieło gatunku, które jest zbiorem zapisów dotyczącym rozmaitych tematów czy problemów powiązanych osobą autora – jego postawą, poglądami, sposobem spojrzenia na świat. Tym, co wyróżnia je na tle twórczości diariuszowej, jest czytanie świata i otaczającej codzienności poprzez lektury. Varga wykorzystuje przeczytane teksty, zakupione książki, układane w swojej bibliotece serie do komentowania współczesnych zjawisk artystycznych,  estetycznych, jak i postaw politycznych. Autor buduje swój obraz świata w oparciu o dokonaną lekturę, czyniąc z niej ostrze krytyki współczesności. Jego biblioteka nie ogranicza się wyłącznie do woluminów, ale zostaje poszerzona o audiotekę i wideotekę. Varga zgodnie z duchem konwergencji pokazuje jak współczesne archipelagi znaczeń obejmują nie tylko słowo pisane, ale dźwięki czy obrazy filmowe. Autor Dziennika hipopotama korzysta z formuły przepisywania, umieszczając przeczytane teksty w kontekście bieżących spraw i wydarzeń, aktualizując i często ideologizując lekturę, poprzez indywidualne, „polityczne” odczytanie. Przepisywanie staje się dla niego strategią czytania, które pozostawia ślad w nim samym.
Ucieleśniona. Paradoksy „Rozbierania Justyny” Czesława Miłosza
Authors: Spólna Anna
Published: April 2022

Wiersz Miłosza Rozbieranie Justyny odczytany został jako metatekstowa całość, wykraczająca poza dialog z Nad Niemnem Orzeszkowej. Utwór ustanawia zarówno relację podmiotu wobec głównej bohaterki powieści, jak wobec Orzeszkowej – patronki literackich powrotów na Litwę i pisarskiego samoograniczenia. Jest też wglądem w proces przejścia od inicjacyjnego przeżycia lekturowego do refleksji świadka Historii. Pełna erotyzmu scena z lustrem, w świetle psychoanalizy Lacana, prowadzi do utożsamienia poetyckiego voyeura z Justyną. Kreowanie dalszych losów Orzelskiej w geście urealnienia fikcji czyni z niej figurę ojczyzny i losu. Połączenie symboliki wanitatywno-katastroficznej z sensualizmem opisu wzmacnia wieloznaczność wiersza z perspektywy postpamięci. Intymny zapis lekturowy przechodzi w kreowanie wspólnoty żywych i umarłych dzięki poetyckiemu słowu. Gospodarz hybrydycznej całości dodaje do utworu późniejszy komentarz, eksponując palimpsestowy charakter fantazmatów, wspomnień z krainy dzieciństwa i źródeł historycznych. Wiersz okazuje się zarówno dwuznacznym hołdem wobec Orzeszkowej, jak inkarnacją toposu natchnienia (intuicji zweryfikowanej przez świadectwa historyczne) i gestem utożsamienia wiekowego poety z sobą dawnym.
Widzia(l)na i Podziwiana. Profesor Zofia Abramowiczówna
Authors: Appel Włodzimierz
Published: April 2022

.
El Pazo de Meirás. Representaciones de un patrimonio en disputa.
Authors: Longhi-Heredia Sebastián Alberto , Morillas-Alcázar José-María , Hernando-Gomez Ángel
Published: April 2022

Tras la polémica suscitada en el año 2018 por la venta del Pazo de Meirás, y después de la decisión judicial del 10 de diciembre de 2020 que ratificaba el paso del Bien de Interés Cultural (BIC) a manos del Estado, el estudio analiza su cobertura periodística en la prensa digital y su reproducción transmedia en Twitter e Instagram. Con el fin de determinar en qué medida y cómo las nociones de patrimonio fueron abordadas por los periodistas en los diarios El Mundo, El País, y 20 Minutos se comparó su tratamiento con la difusión de contenido en las redes sociales durante el mes de diciembre de 2020. La metodología mixta aplicada a un estudio exploratorio se valió del análisis de contenido textual y visual para comprender las representaciones del patrimonio en la prensa digital y en la redes. Se corroboró que la agenda mediática aprovechó el espectáculo generado en el campo patrimonial, destacando el desarrollo de la querella y otros puntos de vistas divergentes: cuestiones relativas a la gestión cultural y patrimonial del monumento, tópicos sociales y políticos ligados a la dictadura española, temáticas relacionas con el accionar del Estado y el expolio de los bienes culturales. La representación patrimonial quedó alejada de la agenda ganando terreno el espectáculo mediático.
A multidisciplinary learning approach: training, preparation and role transition
Authors: Hulse Anna Louise
Published: April 2022

The review in part 1 identified that, although studies address global differences in advanced practice roles, there is limited literature regarding training preparation and role transition, highlighting a gap in educational research.

Aim:

To explore trainee and qualified advanced practitioner learning experiences, how training has prepared learners for clinical practice and role transition. Evaluation of a multidisciplinary learning approach was sought, identifying its impact on developing collaborative learning and working partnerships.

Design and methods:

A small-scale, mixed-methods cross-sectional study was used to gather descriptive data. Convenience sampling was used with two groups: trainees and qualified advanced (paediatric) nurse practitioners/advanced clinical practitioners (ANPs/ACPs). All participants had completed or were undertaking master's level training. An anonymous, voluntary online survey was used to gather quantitative and qualitative data reflecting participant learning experiences. Evaluation research methodologies and their application were examined through exploration of three advanced practice frameworks and a well-established framework for evaluation of training.

Findings:

Overall, responses indicate positive learning experiences, and that current and previous ANP/ACP training in the UK does adequately prepare trainees for practice. However, further improvements in curriculum content are suggested. Consistent with the literature, collaborative multidisciplinary teaching, learning and mentorship were identified as key elements in the learning process and role transition.
Failures in NHS lesson learning
Authors: Tingle John
Published: April 2022

John Tingle, Lecturer in Law, Birmingham Law School, University of Birmingham, discusses patient safety in the light of the recently published Ockenden report
The development of a competency framework for transanal irrigation
Authors: Henderson Michelle , Embleton Rebecca , Wood Lisa , Conway Roseanna
Published: April 2022

Transanal irrigation (TAI) is an established treatment in the management of all types of bowel dysfunction. The National Institute for Health Care and Excellence (NICE) recommends that TAI is initiated by a suitably trained health professional; however, it must then be established how that health professional becomes suitably trained. Much has been published about how TAI works, including its benefits and risks and the types of equipment available. However, no definitive competencies have been agreed among experts in this area. The Northern Region Irrigation Professional Group have recently developed a framework of evidence-based competencies for transanal irrigation. This article discusses the process of development and describes the evidence base and benefits behind the competencies.
A nurse's personal reflections on 2 years of COVID-19
Authors: Kumar Shaila
Published: April 2022

Shaila Kumar reflects on her personal experiences of living through a pandemic and how COVID-19 has impacted her family, her friends and her own wellbeing
Energy Management in Cogeneration System of Sugar Industry Using System Dynamics Modeling
Authors: Yarnal G.S. , Puranik V.S.
Published: April 2022

Energy management is the judicious and effective use of energy to maximize profits and enhance competitive positions through organizational measures and optimization of energy efficiency in the process. India faces a peak electric generating shortage of over 20% and an energy shortage of 12%. India is the world's largest producer of sugar, with over 430 sugar mills producing an estimated 12 millions tons of sugar annually. The rapidly changing markets for sugar and energy provide an excellent opportunity to develop innovative methods to optimize cogenerated power from the sugar plants that can reduce the energy shortage faced by the country. An effort is made in this article to employ a system dynamics methodology to model a cogeneration system in the sugar industry. Simulation of a cogeneration system by system dynamics software is carried out to get different data used for the determination of energy management policy. It is shown that energy management activities can be improved through system dynamics modeling. The various applications point out the advantages of “system dynamics,” particularly in energy management, and assisting decision making procedures in the management level.
Statistical Analysis of Solar-Wind-Biomass Hybrid System Installed at R.G.T.U., Bhopal M.P., India
Authors: Baredar Prashant , Sethi V.K. , Pandey Mukesh
Published: April 2022

This article describes the linkage that exists among the various alternative power sources in the hybrid system. The wind energy system, along with solar photovoltaic panels and a biomass gasifier for the production of electricity, is more suitable among the alternatives available. Wind, solar and biomass energy systems can be used in remote areas. Keeping this in mind, a statistical analysis of the hybrid energy system has been developed for a remote area. Wind and solar data are obtained from a weather monitoring station installed at Energy Park, R.G.T.U., Bhopal, India.
Entrevista com Euleax de Lima Pereira: mais do que eu escrever o poema, é o poema que me escreve.
Authors: Pessah Mariam
Published: April 2022

Entrevista com Euleax de Lima Pereira: mais do que eu escrever o poema, é o poema que me escreve.
Entrevista com Tônio Caetano: o autor nunca sabe tudo, a escrita é desejo e descoberta
Authors: Nogara Marina , Martins Taiane Santi
Published: April 2022

Entrevista com Tônio Caetano: o autor nunca sabe tudo, a escrita é desejo e descoberta
Entrevista com Clara Corleone: O feminismo é fundamental para a conquista de uma cidade, um estado, um país melhor.
Authors: Modesto Edcleberton de Andrade , Vicente Juliane
Published: April 2022

Entrevista com Clara Corleone: O feminismo é fundamental para a conquista de uma cidade, um estado, um país melhor.
Entrevista com Riachão: Eu acredito, e digo a você que eu nasci, parece que eu nasci cantando, eu tenho a impressão que eu nasci cantando
Authors: Do Nascimento Neto João Evangelista , Dourado Lise Mary Arruda , Barbosa Jacson Sandro Paim
Published: April 2022

Entrevista com Riachão: Eu acredito, e digo a você que eu nasci, parece que eu nasci cantando, eu tenho a impressão que eu nasci cantando.
A indesejada das gentes: entre a literatura e a necropolítica
Authors: Dias Denise , Soares de Souza Lícia
Published: April 2022

Este artigo investiga as obras de Jorge Amado, Tereza Batista cansada de guerra, 1972; de Moacyr Scliar, Sonhos Tropicais, 1992; de Pedro Nava, Chão de ferro, 2012; as quais suscitam o testemunho do caos social promovido por epidemias durante o século XX. A partir da leitura dos referidos romances, visualizamos essas doenças como metáforas da exclusão social, isso é observável no conteúdo e pano de fundo que descortinam as mazelas e efeitos sociais causados por elas, especialmente em grupos sociais vulneráveis e menos assistidos pelo poder público. Os escritores lidos fizeram de sua experiência com a literatura um modo de entender o Brasil; por isso, essas obras conduzem o leitor a refletir, de maneira geral, sobre o contexto histórico brasileiro principalmente pelo viés histórico-cultural e sanitário. Assim, nosso objetivo foi investigar de que forma os autores estabelecem, nas obras do corpus, uma discussão em torno da dimensão limítrofe entre vida e morte, explicitando a necropolítica, termo cunhado por Aquille Mbembe, o qual afere que o Estado tem o poder de decidir quem morre e quem vive, a depender de como as políticas públicos vigoram no meio social. O método utilizado, durante a investigação, toma por base os textos teóricos dos filósofos Michel Foucault, Giorgio Agamben e Aquille Mbembe. Os resultados demonstram, via literatura, que o Estado utiliza-se de estratégias de políticas excludentes, fatos demonstrados nas obras em questão, cujo retrato apresenta um país historicamente marcado pelo caos social.

 

Palavras-chave: Biopoder; Necropolítica; Epidemia; Literatura.
Estéticas da Necropolítica no Brasil e no Québec: Crítica da Razão de Exclusão
Authors: Soares de Souza Licia
Published: April 2022

Este texto está em forma de projeto visando a analisar obras das literaturas quebequense e brasileira que põem em cena condições precárias de vida, como “zonas de inimizade” de um estado neoliberal que pouco se preocupa com o bem-estar de seus cidadãos. A Estética da necropolítica se inspira das noções de biopoder de Foucault (1979) e de necropolítica de Mbembe (2014/16), tentando trazer a discussão para os espaços das Américas onde vários grupos sociais são submetidos a condições de vida arriscadas que lhes confere o status de “mortos-vivos”. Nesse sentido, no entre-lugar dos centros urbanos organizados e das periferias negligenciadas pelos poderes públicos (favelas, trapiches, lazaretos, asilos, cárceres, matas, metrôs, etc.) quer-se mapear, analisar e classificar, de acordo com as diferentes estratégias que determinam, de um lado, a crítica da razão da exclusão, em situação transtextual e transacional, e, de outro lado, as mobilidades nos espaços semiosféricos que permitem a ultrapassagem das zonas necropolíticas para as zonas do discurso oficial. A crise da Covid-19 propiciou o escancaramento do projeto neoliberal de aniquilamento das populações carentes, negros, indígenas, migrantes, trabalhadores informais, etc. Nesse caso, busca-se proceder, à luz dos pressupostos da literatura comparada interamericana, ao levantamento e à análise de obras produzidas nos séculos XX e XXI, no contexto híbrido das Américas. Põem-se em evidência obras do Québec (Catherine Mavrikakis (2016), Henri Lamoureux (2003), France Théoret (2006) e do Brasil (Jorge Amado 1937/82), Moacyr Scliar (1992), Márcio Souza (1983)), que revelam muitas zonas de necropolítica que a história foi incapaz de evidenciar. Esta é a Crítica da Razão de Exclusão que pretendemos sistematizar com a análise do presente projeto.

 

Palavras-chave: Necropolítica. Biopoder. Exclusão. Literatura Quebequense. Literatura Brasileira. Semiosfera. Texto-xadrez.
L’initiation à la recherche scientifique à l’école : les littératures francophones dans une perspective citoyenne
Authors: Passos Moraes Luciano
Published: April 2022

Résumé: Le débat autour de la place des littératures dans l’enseignement de base est encore peu exploré puisque la littérature en général occupe un espace assez restreint dans les salles de classe de langues. Si l’on regarde de plus près la réalité de l’enseignement de français au Brésil, il reste clair que l’espace voué aux littératures francophones est presque inexistant. C’est pourquoi nous proposons de repenser l’importance du littéraire dans la formation des étudiants à l’école publique puisque la littérature est un moyen riche en possibilités d’exploration de questions historiques et sociales. Comme possibilité de remédier l’absence des littératures francophones dans les programmes traditionnels, les projets d’initiation à la recherche scientifique peuvent aider à surmonter cette réalité tout en mettant en relief des écrivains et des écrivaines qui n’appartiennent pas à l’Hexagone et qui sont souvent exclu(e)s du canon dominant.
 Mots clés: littératures francophones ; littératures migrantes ; littératures transnationales ; français langue étrangère ; initiation à la recherche scientifique
O corpo na Filosofia Afrodescendente: Implicações possíveis para um novo currículo escolar
Authors: Soares Emanoel Luís Roque , Vasconcelos José Gerardo Vasconcelos
Published: April 2022

RESUMO
O uso dos conceitos de corpo e sexualidade para a filosofia afrodescendente com a intenção de fundamentar um novo currículo com base na cultura ancestral das comunidades do “povo de santo” é capaz de ensinar às pessoas uma convivência sem homofobia e feminicídios. Para tal, utilizaremos a análise de entrevistas com o “povo de santo” e a mitologia da ancestralidade. As religiões de matriz africana mudaram, reinventaram-se, aquilombaram-se e os corpos ressignificaram-se no fluxo da diáspora, proveniente da escravidão do povo negro que se misturou com indígenas, portugueses e ciganos, gerando uma nova cultura que chamaremos de cultura afrodescendente. O corpo ancestral é um corpo que se expressa através do movimento e esse caminho nos indica uma primeira afirmação: os conceitos de corpo de filosofia ocidental clássica não dão conta para o conceito de corpo ancestral de uma filosofia afrodescendente.
Palavras-Chave: Corpo. Currículo. Ancestralidade. Filosofia afrodescendente.
Estimativa de área foliar através de método não-destrutivo em Coccoloba rosea Meisn. e Coccoloba ramosissima Wedd. (Polygonaceae)
Authors: Mariano Kátia Rose Silva , Amorim Solange Maria Costa , Mariano Júnior Carlos Alberto Santiago , Silva Kilma Kelly Almeida
Published: April 2022

O presente estudo teve como objetivo estabelecer uma equação matemática baseada nas relações entre a área foliar real e as medidas lineares do limbo, comprimento e largura, para estimar a área foliar de Coccoloba rosea e C. ramosissima (Polygonaceae). De cada espécie, foram coletadas aleatoriamente 50 folhas de dez indivíduos diferentes. Foram registradas as medidas de maior comprimento e largura do limbo. Em seguida, a área foliar individual foi lida com um medidor de área foliar e então foram aplicadas as seguintes análises de regressão: linear simples, geométrica, exponencial, polinomial e logarítmica. Os critérios utilizados para a seleção da melhor equação foram maior coeficiente de determinação (R2), maior coesão dos pontos e maior praticidade. As equações que se mostraram mais adequadas para a estimativa da área foliar de C. rosea e C. ramosissima foram y=0,7705CL (R2=0,98) e y=0,7416CL (R2=0,91), respectivamente.
Delimitação morfológica e reconhecimento de Orthophytum amoenum (Ule) L.B. Sm. (Bromeliaceae)
Authors: Wanderley Maria das Graças Lapa , Louzada Rafael Batista
Published: April 2022

Orthophytum amoenum é uma espécie rupícola endêmica da Chapada Diamantina, na Bahia. Seu protólogo apresenta descrição incompleta e as coleções de herbário são, em geral, escassas ou pouco representativas, tornando pouco clara a identidade dessa espécie. Na busca do reconhecimento dessa espécie foram efetuadas expedições nas localidades de sua ocorrência, assim como o exame do material-tipo depositado no Herbário do Museu Botânico de Berlim (B). Após o estudo detalhado de populações dessa espécie no campo, onde foi verificada ampla variabilidade morfológica da espécie, e o exame do holótipo da espécie, foi possível evidenciar a real identidade de O. amoenum, sendo aqui detalhadamente descrita e ilustrada, com novos dados de sua distribuição geográfica.
Educação ambiental: uma alternativa para a melhoria da qualidade de vida da comunidade do Bairro Novo Horizonte, Feira de Santana, Bahia, Brasil
Authors: Silva Uiara Catharina Soares e , Costa Grênivel Mota da , Costa Neto Antônio da , Amorim Solange Maria Costa
Published: April 2022

O presente trabalho tem como objetivo principal a avaliação da conscientização ambiental acerca da poluição da Lagoa da Pindoba da comunidade do Bairro Novo Horizonte, Feira de Santana, Bahia. A área de estudo foi caracterizada através de visitas in loco, sendo feita a identificação dos problemas e potenciais que a comunidade considera de maior importância para o seu cotidiano através de entrevistas informais e aleatórias com os moradores e da observação empírica. A partir da realização das entrevistas, pôde-se inferir que a Lagoa da Pindoba encontra-se altamente poluída, sendo celeiro de lixo, esgoto e outros resíduos depositados tanto pelos moradores locais como pela própria UEFS. Pôde-se coligir também que a maioria das crianças não recebe instruções em sua escola (a única local) de que não devem fazer uso, de qualquer espécie, das águas da Lagoa da Pindoba e que, tampouco, recebem noções do manejo e educação ambiental. Finalmente, torna-se evidente a necessidade de implantação de programas de Educação Ambiental voltados à formação de um pensamento crítico, reflexivo, capaz de analisar as complexas relações da realidade natural e social para atuar no ambiente permitindo a construção de um mundo mais justo e igualitário.
Magnetically tunable dual-band terahertz absorption based on guided-mode resonance
Authors: Qi Jingbo , Song Jinlin , Zhang Bo , Luo Zixue , Cheng Qiang
Published: April 2022

We propose a magnetically tunable dual-band terahertz (THz) absorber by using an InAs substrate with a subwavelength zero-contrast germanium grating. The results demonstrate that the absorption peaks in this absorber can be dynamically tuned by changing the intensity and the rotation angle of the applied transverse magnetic field, which is achievable at a moderate order of magnitude of 0.1 Tesla. In addition, we investigate the distribution of magnetic field intensity and find that the magnetically tunable absorption originates from the combination of the magneto-optical effect and the guided-mode resonance effect, where the absorption peaks shift in different directions at normal incidence and oblique incidence. Furthermore, the absorption intensity of the proposed structure could reach 99% with an ultra-high

Q

-factor of 258. This work paves the way for actively adjustable high-resolution THz absorption or a nonreciprocal thermal emitter.
Aircraft visibility in view from below in the long-wave infrared band using infrared cross section
Authors: Mahulikar Shripad P. , Rastogi Pallavi , Bhatt Ashish , Valodi Shubendu P.
Published: April 2022

Aircraft low observables’ features are crucial in the long-wave infrared (LW-IR) band, due to imaging sensors used in IR search and track and in the latest generation of IR-guided missiles. Earthshine irradiance on the aircraft bottom surface is an important source; hence, it is derived using data for atmospheric transmission. Emission due to skin-friction heating (important at high

ε

b
o
t

) and earthshine reflection (important at low

ε

b
o
t

) are compared by a dimensionless ratio for different bottom surface emissivities (

ε

b
o
t

). The infrared cross section of aircraft in direct view from below is obtained in the LW-IR band, which shows that aircraft is seen also due to negative contrast.
Immunohistochemical Assays for Bladder Cancer Molecular Subtyping: Optimizing Parsimony and Performance of Lund Taxonomy Classifiers
Authors: Hardy Céline S.C. , Ghaedi Hamid , Slotman Ava , Sjödahl Gottfrid , Gooding Robert J. , Berman David M. , Jackson Chelsea L.
Published: April 2022

Transcriptomic and proteomic profiling classify bladder cancers into luminal and basal molecular subtypes, with controversial prognostic and predictive associations. The complexity of published subtyping algorithms is a major impediment to understanding their biology and validating or refuting their clinical use. Here, we optimize and validate compact algorithms based on the Lund taxonomy, which separates luminal subtypes into urothelial-like (Uro) and genomically unstable (GU). We characterized immunohistochemical expression data from two muscle-invasive bladder cancer cohorts ( n=193, n=76) and developed efficient decision tree subtyping models using 4-fold cross-validation. We demonstrated that a published algorithm using routine assays (GATA3, KRT5, p16) classified basal/luminal subtypes and basal/Uro/GU subtypes with 86%–95% and 67%–86% accuracies, respectively. KRT14 and RB1 are less frequently used in pathology practice but achieved the simplest, most accurate models for basal/luminal and basal/Uro/GU discrimination, with 93%–96% and 85%–86% accuracies, respectively. More complex models with up to eight antibodies performed no better than simpler two- or three-antibody models. We conclude that simple immunohistochemistry classifiers can accurately identify luminal (Uro, GU) and basal subtypes and are appealing options for clinical implementation.
Visualizing omicron: COVID-19 deaths vs. cases over time
Authors: Arnaout Ramy , Arnaout Rima
Published: April 2022

For most of the COVID-19 pandemic, the daily focus has been on the number of cases, and secondarily, deaths. The most recent wave was caused by the omicron variant, first identified at the end of 2021 and the dominant variant through the first part of 2022. South Africa, one of the first countries to experience and report data regarding omicron (variant 21.K), reported far fewer deaths, even as the number of reported cases rapidly eclipsed previous peaks. However, as the omicron wave has progressed, time series show that it has been markedly different from prior waves. To more readily visualize the dynamics of cases and deaths, it is natural to plot deaths per million against cases per million. Unlike the time-series plots of cases or deaths that have become daily features of pandemic updates during the pandemic, which have time as the x-axis, in a plot of deaths vs. cases, time is implicit, and is indicated in relation to the starting point. Here we present and briefly examine such plots from a number of countries and from the world as a whole, illustrating how they summarize features of the pandemic in ways that illustrate how, in most places, the omicron wave is very different from those that came before. Code for generating these plots for any country is provided in an automatically updating GitHub repository.
Comparative expression of soluble, active human kinases in specialized bacterial strains
Authors: Sunderhaus Allison , Imran Ramsha , Enoh Elanzou , Adedeji Adesola , Obafemi Taiye , Abdel Aziz May H.
Published: April 2022

Kinases act as molecular switches for cellular functions and are involved in multiple human pathogeneses, most notably cancer. There is a continuous need for soluble and active kinases for in-vitro drug discovery and structural biology purposes. Kinases remain challenging to express using Escherichia coli, the most widely utilized host for heterologous expression. In this work, four bacterial strains, BL21 (DE3), BL21 (DE3) pLysS, Rosetta, and Arctic Express, were chosen for parallel expression trials along with BL21 (DE3) complemented with folding chaperones DnaJ/K and GroEL/ES to compare their performance in producing soluble and active human kinases. Three representative diverse kinases were studied, Epidermal Growth Factor Receptor kinase domain, Aurora Kinase A kinase domain, and Mitogen-activated protein Kinase Kinase. The genes encoding the kinases were subcloned into pET15b bacterial plasmid and transformed into the bacterial strains. Soluble kinase expression was tested using different IPTG concentrations (1–0.05 mM) at varying temperatures (37°C– 10°C) and induction times (3–24 hours). The optimum conditions for each kinase in all strains were then used for 1L large scale cultures from which each kinase was purified to compare yield, purity, oligomerization status, and activity. Although using specialized strains achieved improvements in yield and/or activity for the three kinases, none of the tested strains was universally superior, highlighting the individuality in kinase expression.
Personalized Reimbursement Model (PRM) program: A real-world data platform of cancer drugs use to improve and personalize drug pricing and reimbursement in France
Authors: Squara Pierre-Alexandre , Luu Vinh-Phuc , Pérol David , Coudert Bruno , Machuron Valérie , Bachot Camille , Samelson Laurence , Florentin Virginie , Pinguet Jean-Marc , Ben Hadj Yahia Béchir
Published: April 2022

Objective

This article describes the Personalized Reimbursement Model (PRM) program methodology, limitations, achievement and perspectives in using real-world data of cancer drugs use to improve and personalize drug pricing and reimbursement in France.

Materials and methods

PRM platform aggregates Electronic Pharmacy Records (EPR) data from French medical centers (PRM centers) to build retrospective cohorts of patients treated with injectable cancer drugs in a hospital setting. Data extracted on January 1st, 2020, from breast cancer (BC) patients who received trastuzumab, trastuzumab emtansin or pertuzumab since January 1st, 2011, and from lung cancer (LC) patients who received bevacizumab or atezolizumab since January 1st, 2015, enabled recovering their injectable cancer drugs history from diagnosis date until December 30th, 2019, and served as dataset for assessment.

Results

123 PRM centers provided data from 30,730 patients (25,660 BC and 5,070 LC patients respectively). Overall, 20,942 (82%) of BC and 4,716 (93%) of LC patients were analyzed. Completion rate was above 98% for patients characteristics, diagnostic and treatment related data. PRM centers cover 48% and 33% of BC and LC patients in-hospital therapeutic management in France, respectively. Distribution of BC and LC patients therapeutic management, by medical center category and geographic location, was similar in PRM centers to all French medical centers, ensuring the representativeness of the PRM platform.

Conclusion

PRM Platform enabled building a national database generating on demand Real-World Evidence based on EPR. This enabled the first performance-based risk-sharing arrangements based on PRM data, between the CEPS and Roche, for atezolizumab cancer immunotherapy in metastatic non-small cell lung cancer indication.
Recommendations for the pharmacological treatment of treatment-resistant depression: A systematic review protocol
Authors: Gabriel Franciele Cordeiro , Stein Airton Tetelbom , de Melo Daniela Oliveira , Fontes-Mota Géssica Caroline Henrique , dos Santos Itamires Benício , Rodrigues Camila da Silva , Rodrigues Mônica Cristiane , Fráguas Renério , Florez Ivan D. , Correia Diogo Telles , Ribeiro Eliane
Published: April 2022

Introduction

Depression is a serious and widespread mental health disorder. Although effective treatment does exist, a significant proportion of patients with depression fail to respond to antidepressant treatment trials, a condition named treatment-resistant depression. Efficient approach should be given this condition in order to revert the burden caused by depression. Clinical practice guidelines (CPGs) are evidence-based health promotion instruments to improve diagnosis and treatment. CPGs recommendations for treatment-resistant depression must be trustworthy. The objective of the proposed study is to systematically identify, appraise the quality of CPGs for the treatment of depression and elaborate a synthesis of recommendations for treatment-resistant depression of CPGs considered to be of high quality and with high quality recommendations.

Methods and analysis

We will search the databases of organizations, such as PubMed, Embase, Cochrane Library, PsycInfo, and the Virtual Health Library, and organizations that develop CPGs. Three independent researchers will assess the quality of the CPGs and their recommendations using the AGREE II and AGREE-REX instruments, respectively. Given the identification of divergences and convergences as well as weak and strong points among high quality CPGs, our work may help developers, clinicians and eventually patients.

Ethics and dissemination

No ethical approval is required for a systematic review, as no patient data will be used. The research results will be disseminated in conferences and submitted to a peer reviewed journal.
Global structural stability and the role of cooperation in mutualistic systems
Authors: Portillo José R. , Soler-Toscano Fernando , Langa José A.
Published: April 2022

Dynamical systems on graphs allow to describe multiple phenomena from different areas of Science. In particular, many complex systems in Ecology are studied by this approach. In this paper we analize the mathematical framework for the study of the structural stability of each stationary point, feasible or not, introducing a generalization for this concept, defined asGlobal Structural Stability. This approach would fit with the proper mathematical concept of structural stability, in which we find a full description of the complex dynamics on the phase space due to nonlinear dynamics. This fact can be analyzed as an informational field grounded in a global attractor whose structure can be completely characterized. These attractors are stable under perturbation and suppose the minimal structurally stable sets. We also study in detail, mathematically and computationally, the zones characterizing different levels of biodiversity in bipartite graphs describing mutualistic antagonistic systems of population dynamics. In particular, we investigate the dependence of the region of maximal biodiversity of a system on its connectivity matrix. On the other hand, as the network topology does not completely determine the robustness of the dynamics of a complex network, we study the correlation between structural stability and several graph measures. A systematic study on synthetic and biological graphs is presented, including 10 mutualistic networks of plants and seed-dispersal and 1000 random synthetic networks. We compare the role of centrality measures and modularity, concluding the importance of just cooperation strength among nodes when describing areas of maximal biodiversity. Indeed, we show that cooperation parameters are the central role for biodiversity while other measures act as secondary supporting functions.
Distinguish Thyroid Malignant from Benign Alterations using Trace Element Contents in Nodular Tissue determined by Neutron Activation and Inductively Coupled Plasma Mass Spectrometry
Authors: Zaichick Vladimir
Published: April 2022

Background
Thyroid benign (TBN) and malignant (TMN) nodules are a common thyroid lesion. The differentiation of TMN often remains a clinical challenge and further improvements of TMN diagnostic accuracy are warranted. The aim of present study was to evaluate possibilities of using differences in trace elements (TEs) contents in nodular tissue for diagnosis of thyroid malignancy.

Methods
Contents of TEs such as silver (Ag), aluminum (Al), boron (B),, beryllium (Be), bismuth (Bi), cadmium (Cd), cerium (Ce), cobalt (Co), chromium (Cr), cesium (Cs), iron (Fe), gallium (Ga), mercury (Hg), iodine (I), lanthanum (La), lithium (Li), manganese (Mn), molybdenum (Mo), neodymium (Nd), nickel (Ni), lead (Pb), praseodymium (Pr), rubidium (Rb), antimony (Sb), scandium (Sc), selenium (Se), samarium (Sm), tin (Sn), thallium (Tl), uranium (U), yttrium (Y), and zinc (Zn) were prospectively evaluated in nodular tissue of thyroids with TBN (79 patients) and to TMN (41 patients). Measurements were performed using a combination of non-destructive instrumental neutron activation analysis with high resolution spectrometry of short- and long-lived radionuclides (INAA-SLR and INAA-LLR, respectively) and destructive method such as inductively coupled plasma mass spectrometry (ICP-MS).

Results
It was observed that in TMN tissue the mean mass fractions of Be, Fe, I, Sc, and Se are approximately 1.9, 1.7, 14, 3.1, and 1.6 times, respectively, lower while the mass fraction of Ga, Mo, and Rb 62%, 51%, and 33%, respectively, higher than those in TBN tissue. Contents of Ag, Al, B, Bi, Cd, Ce, Co, Cr, Cs, Hg, La, Li, Mn, Nd, Ni, Pb, Pr, Sb, Sm, Sn, Tl, U, Y, and Zn found in the TBN and TMN groups of nodular tissue samples were similar.

Conclusions
It was proposed to use the I mass fraction, as well as I/Ga, I/Mo, and I/Rb mass fraction ratios in a needle-biopsy of thyroid nodules as a potential tool to diagnose thyroid malignancy. Further studies on larger number of samples are required to confirm our findings and proposals.
La resignificación de la reforma educativa 2013 de México en el espacio escolar: Estudios de caso en dos entornos rurales
Authors: Ruiz María Mercedes , Ortiz Leonardo Oliver
Published: April 2022

En esta investigación se explora el proceso de resignificación de la reforma educativa de 2013 por parte de los actores escolares en dos contextos rurales de los estados de México y Michoacán, cuyos subsistemas educativos destacan por su magnitud y la contrastante orientación política de sus corrientes sindicales, la primera oficialista y la segunda disidente. Ambos se toman como estudios de caso simultáneos con el fin de profundizar en las diversas maneras en cómo la reforma educativa es vivida y resignificada en función de la lógica de la puesta en acto de Stephen Ball. Con la recuperación y sistematización de las interpretaciones que cada uno de estos actores construyen, se busca contribuir a la comprensión en el nivel micropolítico de las reformas educativas, así como indagar en las mediaciones que intervienen en el proceso de resignificación. En dicho proceso, cobra relevancia la autoría de los sujetos escolares y comunitarios en relación a las normativas con aspiraciones prescriptivas, que son reelaboradas desde el nivel micropolítico y territorial. Estas reinterpretaciones se posicionan como discursos que reivindican las voces excluidas de la narrativa oficial.
Integrating Local Wisdom into ELT Materials for Secondary School Students in Semarang
Authors: Wulandari Dwi , Sundari Wiwiek , Ellysafny Cut Aja Puan
Published: April 2022

This study is Research & Development which contains three phases (explorative, model design, and try-out).  The research aims to develop a teaching material which integrates Javanese local wisdom   for the students of secondary school in Semarang.   Phase 1 (the explorative study) consists of two parts: book review and needs analysis (questionnaire and interview). The results of the first phase show that the existing  three books do not include aspects of  local wisdom. While the needs analysis show that the respondents  agreed to integrate aspects of local wisdom with the  benefits as follows: (a) supporting the learning process, (b) making the students understand  the materials  more easily, (c) enhancing the understanding of local cultures and character education. In phase 2 and phase 3 (model design and try-out in three schools), the findings indicate that  integrating local wisdom, i.e. a traditional song ”menthog-menthog” can enliven the classroom atmosphere. In addition, based on the respondent perception, the integration of local wisdom  would enrich the knowledge of local cultures as well as help the students understand ELT texts.
Enhancing the implementation of bilingual education at university through practice: Analysis of CLIL trial lessons by an ESP teacher
Authors: Contero Urgal Candela
Published: April 2022

University teacher training specialised in bilingual education is spreading around Spanish universities. Particularly in Andalusia, where our research originates, universities are searching for systematised methods to train their future bilingual teachers in Content and Language Integrated Learning (CLIL). This paper presents the case of the University of Cadiz, where this study was carried out. This university followed a new training formula led by an ESP (English for Specific Purposes) teacher who performed the role of CLIL teacher trainer. Based on AUTHOR’s (2017) description of the aforesaid CLIL teacher training scheme known as “CLILUT courses” (that is to say, CLIL Training or University Teachers), this study focuses on an in-depth analysis  of CLIL trial lesson plans elaborated within such a peer-teacher environment. The present study is then aimed at examining the data obtained through in-class direct observation of 68 CLIL trial lessons which were created from 2010 to 2014 at the University of Cádiz and analysed with the help of rubrics created upon Nunan’s theory (1989). Results show that ESP teachers can offer substantial help for new CLIL university teachers who might face specific foreign language-related problems when starting to take part in bilingual programmes.
The Effectiveness of Local Wisdom-Based Integrative Thematic English Education Games in 2013 Curriculum
Authors: Arvianti Indah - , Wahyuni Ana -
Published: April 2022

The 2013 curriculum at the elementary level emphasizes the competence of students focused on character education. However, this curriculum does not include English as a means of mastering global knowledge. Based on this, the purposes of this research are to fulfill the absence of English subject which has not been integrated thematically in 2013 curriculum and to examine the effectiveness of English learning model using local wisdom-based thematic integrative education games for the 1st grade of elementary school students as well as to maintain local wisdom as a strategy to construct the character of youth nation. Data collection methods are interview, observation, questionnaire, and literature study. The other method is the pre-test and post-test experimental design. Respondents of this study are 148 students of the 1st grade elementary school in 17 elementary schools in Central Semarang. The results of both tests show that this model has proven to be effective in increasing the English competence of those students. This learning media is considered appropriate because this media is very interesting and fun so that it can encourage students to learn English and make students enthusiastic in learning so that it gives good results.
Morphological Analysis of Manggarai Language
Authors: Mangga Stephanus
Published: April 2022

This study was a morphology descriptive analysis of Manggarai language (BM) which was focused on three areas those are language typology based on the level of morphological use namely analytic, synthetic, and polysynthetic; morpheme identification; and morphological process. Therefore the aim of this study was to describe them. Data used in this study were library data which were collected using simak method and introspection method. The data were analyzed using agih method. Besides, there are three main results of the analysis data in this study. The first showed that BM is the analytic language because morphologically words in BM are monomorphemic. The second finding showed that bound morphemes in BM not related to affixation, but they are related to the combination of synonyms and clitictation. The last finding found that there is no affixation in the morphological process, but it is only compound words and reduplication.
Sundanese Language Maintenance Based on The Heterogeneity of The Speakers
Authors: Junawaroh Siti , Sobarna Cece - , - Wahya - , Riyanto Sugeng -
Published: April 2022

The issue of maintaining the Sundanese Brebes language in the Sundanese community in Brebes Regency was raised because the existence of the Sundanese Brebes language is potentially threatened economically, socially, and politically by Javanese, Indonesian, and foreign languages. Previous studies suggest that monolingual communities are vulnerable to switch to languages with higher political power, whereas established multilingual communities tend to survive. However, this is different from the Sundanese Brebes language. The purpose of this paper is to examine the pattern of Sundanese Brebes maintenance based on heterogeneity. The number of respondents in this study was 400. The results of the analysis showed that monolingual communities type 1 and 2 maintain Sundanese Brebes language more active than multilingual communities type 3 and 4. In the monolingual community, the presence of Javanese and Indonesian languages with dominant economic and political power did not influence significantly language maintenance. In contrast, the maintenance of Sundanese Brebes in the multilingual community is more passive. The maintenance of Sundanese Brebes still occurs because of the strong identity of Sundanese Brebes. This study is expected to contribute to the study of language maintenance patterns in several community characteristics.
Defining Appropriate Curriculum for English Diploma Program
Authors: Wulandari Dwi
Published: April 2022

This study is aiming at looking at the appropriate curriculum for Diploma Program in English by focusing on the targetted competence and the unique feature of the program. As a vocational school, English diploma program is facing problems in defining its own characteristics. The so far  called diploma program is actually the shorthened term of the undergraduate English program with the absence of literary and linguistics related courses, and focused merely on the English skill learning. Although some practical skills other than English have been embedded in the curriculum, such as the additional courses in tourism and public relations, still the program missed the answer for its basic question; what the targetted competence and the unique feature of the program are. This research is done in trying to find the answer by doing both library research trying to take a look the ideal features of English Diploma programs, and interview trying to see the nature and the specific goal targetted by the management in handling the programs as well as the difficulties to match the present condition with the ideal one. The study reveals that some of English diploma programs may face the same issue of not being clear in targetting the competence as the vocational program, although some have found what is being idealized.
Learning to Write Descriptive Texts Based on Batik Culture of BIPA Students at the Indonesian Embassy in London
Authors: Yulianeta Yulianeta , Amandangi Dewi Prajnaparamita
Published: April 2022

Learning Indonesian as a Foreign Fuller (BIPA) is carried out along with the introduction of culture to learners. Apart from language learning, the introduction of culture can also provide a more concrete picture of Indonesian identity. This article focuses on the study of writing skills, in particular, on writing descriptive texts. The learning to write based on Indonesian culture, especially batik culture. Using qualitative methods, this research was conducted for approximately three months in the period of September-December 2019. The data of this study were the ability to write descriptive texts of BIPA students at the Indonesian Embassy in London. The research subjects were 9 BIPA students at the Indonesian Embassy in London. The results of this study are descriptions of the learning to write descriptive texts of BIPA students and descriptions of culture-based learning of BIPA students at the Indonesian Embassy in London. The descriptive text is used as an alternative approach in learning to write for BIPA because it makes it easier for the students to learn vocabulary as well as culture.
Pronunciation Errors of English Front Vowels by Yemeni EFL Learners
Authors: Al-Hamzi Ali Mohammed Saleh , Al-Shrgabi Abdul hakim Ahmed Sallam , Al-Haidari Ali Saleh Ahmed , Faraj Mansour Mohamed Ali , Al-Housali Taha Ahmed Ali
Published: April 2022

In the domain of English as a foreign language, many learners still face some difficulties in articulating vowel sounds of English, particularly the front ones. This study attempts to describe Yemeni EFL learners' errors while pronouncing the English front vowels. The subject of this study was the eighth-semester students studying at the English department, Faculty of Education, Mahweet branch, Sana'a University. The descriptive qualitative approach was utilized in this study. The data was collected by recording learners' pronunciation of English front vowel minimal pairs. The data was then compared with the ones produced by an English native speaker. The findings resulted were confirmed by the spectrogram technique to identify the formants of F1 and F2 made by the learners in Praat Software Device. English front vowels /i / - / I /- / Ԑ / and / ae / were the target sounds. The study's findings revealed that Yemeni EFL learners' pronunciation differs from those produced by native English speakers. It was also revealed that Yemeni EFL learners are still struggling in articulating English front vowel sounds due to the influence of the sound system of their native language that causes such pronunciation problems in the target language.