bluuebunny/crossref_metadata_2025 huggingface dataset:
A Systematic Review of Tear Vascular Endothelial Growth Factor and External Eye Diseases
Authors: Chan Jaclyn , Lim Gavril , Lee Ryan , Tong Louis
Published: January 2024

We aim to summarize the current evidence of Vascular endothelial growth factors (VEGF)s in external eye diseases and determine whether serum and plasma VEGF levels are associated with tear and ocular surface tissues. A systematic search of PUBMED and EMBASE was conducted using PRISMA guidelines between October 2022 and November 2023, with no restriction on language or publication date. Search terms included relevant MESH terms. These studies were evaluated for quality, and an assessment of the risk of bias was also carried out. Extracted data were then visually represented through relevant tables or figures. The initial literature search yielded 777 studies from PUBMED, 944 studies from EMBASE, and 10 studies from manual searches. Fourteen eligible studies were identified from 289 articles published from 2000 to 2023 in the English language or with English translations, including rabbit models, murine models, and human-derived samples. Most studies were retrospective in nature and case–control studies. Various common external eye diseases, such as dry eye disease (DED) and allergic eye disease were investigated. Despite limitations and small sample sizes, researchers have found elevated tissue levels of the VEGF in the vascularized cornea, especially in animal models, but there is no evidence of clear changes in the tear concentrations of VEGF in DED and allergic eye disease. Tear VEGF is associated with corneal vascularization. Anti-VEGF therapies may have the potential to manage such conditions.
Progress in Predicting Ames Test Outcomes from Chemical Structures: An In-Depth Re-Evaluation of Models from the 1st and 2nd Ames/QSAR International Challenge Projects
Authors: Uesawa Yoshihiro
Published: January 2024

The Ames/quantitative structure–activity relationship (QSAR) International Challenge Projects, held during 2014–2017 and 2020–2022, evaluated the performance of various predictive models. Despite the significant insights gained, the rules allowing participants to select prediction targets introduced ambiguity in model performance evaluation. This reanalysis identified the highest-performing prediction model, assuming a 100% coverage rate (COV) for all prediction target compounds and an estimated performance variation due to changes in COV. All models from both projects were evaluated using balance accuracy (BA), the Matthews correlation coefficient (MCC), the F1 score (F1), and the first principal component (PC1). After normalizing the COV, a correlation analysis with these indicators was conducted, and the evaluation index for all prediction models in terms of the COV was estimated. In total, using 109 models, the model with the highest estimated BA (76.9) at 100% COV was MMI-VOTE1, as reported by Meiji Pharmaceutical University (MPU). The best models for MCC, F1, and PC1 were all MMI-STK1, also reported by MPU. All the models reported by MPU ranked in the top four. MMI-STK1 was estimated to have F1 scores of 59.2, 61.5, and 63.1 at COV levels of 90%, 60%, and 30%, respectively. These findings highlight the current state and potential of the Ames prediction technology.
Ligand-Based Design of Selective Peptidomimetic uPA and TMPRSS2 Inhibitors with Arg Bioisosteres
Authors: Müller Patrick , Zimmer Collin , Frey Ariane , Holzmann Gideon , Weldert Annabelle Carolin , Schirmeister Tanja
Published: January 2024

Trypsin-like serine proteases are involved in many important physiological processes like blood coagulation and remodeling of the extracellular matrix. On the other hand, they are also associated with pathological conditions. The urokinase-pwlasminogen activator (uPA), which is involved in tissue remodeling, can increase the metastatic behavior of various cancer types when overexpressed and dysregulated. Another member of this protease class that received attention during the SARS-CoV 2 pandemic is TMPRSS2. It is a transmembrane serine protease, which enables cell entry of the coronavirus by processing its spike protein. A variety of different inhibitors have been published against both proteases. However, the selectivity over other trypsin-like serine proteases remains a major challenge. In the current study, we replaced the arginine moiety at the P1 site of peptidomimetic inhibitors with different bioisosteres. Enzyme inhibition studies revealed that the phenylguanidine moiety in the P1 site led to strong affinity for TMPRSS2, whereas the cyclohexylguanidine derivate potently inhibited uPA. Both inhibitors exhibited high selectivity over other structurally similar and physiologically important proteases.
M6229 Protects against Extracellular-Histone-Induced Liver Injury, Kidney Dysfunction, and Mortality in a Rat Model of Acute Hyperinflammation
Authors: Reutelingsperger Chris P. M. , Gijbels Marion J. , Spronk Henri , Van Oerle Rene , Schrijver Roy , Ekhart Peter , de Kimpe Sjef , Nicolaes Gerry A. F.
Published: January 2024

Extracellular histones have been shown to act as DAMPs in a variety of inflammatory diseases. Moreover, they have the ability to induce cell death. In this study, we show that M6229, a low-anticoagulant fraction of unfractionated heparin (UFH), rescues rats that were challenged by continuous infusion of calf thymus histones at a rate of 25 mg histones/kg/h. Histone infusion by itself induced hepatic and homeostatic dysfunction characterized by elevated activity of hepatic enzymes (ASAT and ALAT) and serum lactate levels as well as by a renal dysfunction, which contributed to the significantly increased mortality rate. M6229 was able to restore normal levels of both hepatic and renal parameters at 3 and 9 mg M6229/kg/h and prevented mortality of the animals. We conclude that M6229 is a promising therapeutic agent to treat histone-mediated disease.
Locally Synthetized 17-β-Estradiol Reverses Amyloid-β-42-Induced Hippocampal Long-Term Potentiation Deficits
Authors: Bellingacci Laura , Canonichesi Jacopo , Sciaccaluga Miriam , Megaro Alfredo , Mazzocchetti Petra , Di Mauro Michela , Costa Cinzia , Di Filippo Massimiliano , Pettorossi Vito Enrico , Tozzi Alessandro
Published: January 2024

Amyloid beta 1-42 (Aβ42) aggregates acutely impair hippocampal long-term potentiation (LTP) of synaptic transmission, and 17β-estradiol is crucial for hippocampal LTP. We tested whether boosting the synthesis of neural-derived 17β-estradiol (nE2) saves hippocampal LTP by the neurotoxic action of Aβ42. Electrophysiological recordings were performed to measure dentate gyrus (DG) LTP in rat hippocampal slices. Using a pharmacological approach, we tested the ability of nE2 to counteract the LTP impairment caused by acute exposure to soluble Aβ42 aggregates. nE2 was found to be required for LTP in DG under physiological conditions. Blockade of steroid 5α-reductase with finasteride, by increasing nE2 synthesis from testosterone (T), completely recovered LTP in slices treated with soluble Aβ42 aggregates. Modulation of the glutamate N-methyl-D aspartate receptor (NMDAR) by memantine effectively rescued the LTP deficit observed in slices exposed to Aβ42, and memantine prevented LTP reduction observed under the blocking of nE2 synthesis. nE2 is able to counteract Aβ42-induced synaptic dysfunction. This effect depends on a rapid, non-genomic mechanism of action of nE2, which may share a common pathway with glutamate NMDAR signaling.
Fertilization- and Irrigation-Modified Bacterial Community Composition and Stimulated Enzyme Activity of Eucalyptus Plantations Soil
Authors: Huo Chunyu , Mao Jianhui , Zhang Jianlang , Yang Xinzhu , Gao Shangkun , Li Jiyue , He Qian , Tang Guangda , Xie Xianan , Chen Zujing
Published: January 2024

Irrigation and fertilization are essential management practices for increasing forest productivity. They also impact the soil ecosystem and the microbial population. In order to examine the soil bacterial community composition and structure in response to irrigation and fertilization in a Eucalyptus plantations, a total of 20 soil samples collected from Eucalyptus plantations were analyzed using high-throughput sequencing. Experimental treatments consisting of control (CK, no irrigation or fertilization), fertilization only (F), irrigation only (W), and irrigation and fertilization (WF). The results showed a positive correlation between soil enzyme activities (urease, cellulase, and chitinase) and fertilization treatments. These enzyme activities were also significantly correlated with the diversity of soil bacterial communities in Eucalyptus plantations.. Bacteria diversity was considerably increased under irrigation and fertilization (W, F, and WF) treatments when compared with the CK treatment. Additionally, the soil bacterial richness was increased in the Eucalyptus plantations soil under irrigation (W and WF) treatments. The Acidobacteria (38.92–47.9%), Proteobacteria (20.50–28.30%), and Chloroflexi (13.88–15.55%) were the predominant phyla found in the Eucalyptus plantations soil. Specifically, compared to the CK treatment, the relative abundance of Proteobacteria was considerably higher under the W, F, and WF treatments, while the relative abundance of Acidobacteria was considerably lower. The contents of total phosphorus, accessible potassium, and organic carbon in the soil were all positively associated with fertilization and irrigation treatments. Under the WF treatment, the abundance of bacteria associated with nitrogen and carbon metabolisms, enzyme activity, and soil nutrient contents showed an increase, indicating the positive impact of irrigation and fertilization on Eucalyptus plantations production. Collectively, these findings provide the scientific and managerial bases for improving the productivity of Eucalyptus plantations.
Dysfunctional Postnatal Mitochondrial Energy Metabolism in a Patient with Neurodevelopmental Defects Caused by Intrauterine Growth Restriction Due to Idiopathic Placental Insufficiency
Authors: Uittenbogaard Martine , Gropman Andrea L. , Whitehead Matthew T. , Brantner Christine A. , Gropman Eliana , Chiaramello Anne
Published: January 2024

We report the case of a four-year-old male patient with a complex medical history born prematurely as the result of intrauterine growth restriction due to placental insufficiency. His clinical manifestations included severe neurodevelopmental deficits, global developmental delay, Pierre-Robin sequence, and intractable epilepsy with both generalized and focal features. The proband’s low levels of citrulline and lactic acidosis provoked by administration of Depakoke were evocative of a mitochondrial etiology. The proband’s genotype–phenotype correlation remained undefined in the absence of nuclear and mitochondrial pathogenic variants detected by deep sequencing of both genomes. However, live-cell mitochondrial metabolic investigations provided evidence of a deficient oxidative-phosphorylation pathway responsible for adenosine triphosphate (ATP) synthesis, leading to chronic energy crisis in the proband. In addition, our metabolic analysis revealed metabolic plasticity in favor of glycolysis for ATP synthesis. Our mitochondrial morphometric analysis by transmission electron microscopy confirmed the suspected mitochondrial etiology, as the proband’s mitochondria exhibited an immature morphology with poorly developed and rare cristae. Thus, our results support the concept that suboptimal levels of intrauterine oxygen and nutrients alter fetal mitochondrial metabolic reprogramming toward oxidative phosphorylation (OXPHOS) leading to a deficient postnatal mitochondrial energy metabolism. In conclusion, our collective studies shed light on the long-term postnatal mitochondrial pathophysiology caused by intrauterine growth restriction due to idiopathic placental insufficiency and its negative impact on the energy-demanding development of the fetal and postnatal brain.
Cardiovascular Complications in Patients with Heart Failure and COVID-19: CARDIO COVID 19-20 Registry
Authors: Speranza Mario , López-López Juan D. , Schwartzmann Pedro , Morr Igor , Rodríguez-González María Juliana , Buitrago Andrés , Pow-Chon-Long Freddy , Passos Luiz Carlos , Rossel Víctor , Perna Eduardo Roque , Escalante Manuela , Romero Alexander , Arteaga-Tobar Andrea Alejandra , Quesada Daniel , Alarco Walter , Gómez-Mesa Juan Esteban
Published: January 2024

Since early 2020, different studies have shown an increased prevalence of COVID-19 and poorer prognosis in older adults with cardiovascular comorbidities. This study aimed to assess the impact of heart failure (HF) on cardiovascular complications, intensive care unit (ICU) admissions, and in-hospital mortality in patients hospitalized with COVID-19. The CARDIO COVID 19-20 registry includes 3260 hospitalized patients with a COVID-19 serological diagnosis between May 2020 and June 2021 from Latin American countries. A history of HF was identified in 182 patients (5.6%). In patients with and without previous HF, the incidence of supraventricular arrhythmia was 16.5% vs. 6.3%, respectively (p = 0.001), and that of acute coronary syndrome was 7.1% vs. 2.7%, respectively (p = 0.001). Patients with a history of HF had higher rates of ICU admission (61.5% vs. 53.1%, respectively; p = 0.031) and in-hospital mortality (41.8% vs. 24.5%, respectively; p = 0.001) than patients without HF. Cardiovascular mortality at discharge (42.1% vs. 18.5%, respectively; p < 0.001) and at 30 days post-discharge (66.7% vs. 18.0%, respectively) was higher for patients with a history of HF than for patients without HF. In patients hospitalized with COVID-19, previous history of HF was associated with a more severe cardiovascular profile, with increased risk of cardiovascular complications, and poor in-hospital and 30-day outcomes.
Erythroderma: A Retrospective Study of 212 Patients Hospitalized in a Tertiary Center in Lower Silesia, Poland
Authors: Kliniec Katarzyna , Snopkowska Aleksandra , Łyko Magdalena , Jankowska-Konsur Alina
Published: January 2024

Erythroderma is a condition characterized by erythema affecting at least 90% of the skin surface area. It can be caused by various underlying conditions. Due to nonspecific clinical and laboratory findings, determining the cause may pose a challenge. In the retrospective study, we identified 212 patients hospitalized for erythroderma in the Department of Dermatology, Venereology, and Allergology at Wroclaw Medical University between January 2012 and March 2022. Clinical, laboratory, and histopathological features, as well as the management of patients, were studied. The median age of adults was 61 years (IQR = 47–68). The most common causes of erythroderma were psoriasis (n = 49, 24.01%), followed by atopic dermatitis (AD) (n = 27, 13.23%), and cutaneous T-cell lymphomas (CTCL) (n = 27, 13.23%). Despite laboratory tests and histopathological examination, the etiology of erythroderma remained undetermined in 39 cases (19.12%). In 70.59% of patients, it was the first episode of erythroderma, while 29.41% experienced a recurrent episode. Regardless of the etiology of erythroderma, patients were most frequently treated with systemic antihistamines (146 cases, 71.57%) and systemic steroids (132 cases, 64.71%). Patients with idiopathic erythroderma constitute the greatest diagnostic and therapeutic challenge, requiring particularly thorough evaluation.
The Improvement of Trunk Muscle Endurance in Adolescents with Idiopathic Scoliosis Treated with ScoliBrace® and the ScoliBalance® Exercise Approach
Authors: Marchese Rosemary , Du Plessis Juan , Pooke Tamara , McAviney Jeb
Published: January 2024

The impact of scoliosis bracing combined with physiotherapeutic scoliosis-specific exercises (PSSE) on trunk muscle endurance in adolescents with idiopathic scoliosis is unknown. ScoliBrace®, a rigid, three-dimensional, over-corrective thoraco-lumbar-sacral orthosis (TLSO), and ScoliBalance®, a PSSE program, were used to treat adolescent idiopathic scoliosis (AIS) patients. A retrospective study of the trunk muscle endurance of 33 AIS patients who received ScoliBrace® and ScoliBalance® was conducted. The patients were treated with ScoliBrace® and an individualized ScoliBalance® program. Trunk extensor muscle endurance (TE) and abdominal muscle endurance (AE) tests were performed at initial assessment and then at averages of 6.6 and 24.4 weeks of treatment. The data were analyzed using the Wilcoxon signed-rank test, Stata version 15.1. The participants were aged 13.24 years (SD = 1.64) with a mean Cobb angle of 38.97° (SD = 9.49°). TE improved significantly (p < 0.001) at both short- and medium-term intervals using ScoliBalance® and ScoliBrace® in the AIS patients. AE also showed significant improvement between baseline and short-term follow-up, with non-significant improvement at medium-term follow-up. Overall, trunk muscle endurance showed improvement in the AIS patients using ScoliBrace® and ScoliBalance®. Future research is required to determine the individual and combined effects of each treatment. However, it seems likely that trunk muscle endurance will not deteriorate in AIS patients with this combined treatment.
The California Coast and Living Shorelines—A Critical Look
Authors: Griggs Gary B.
Published: January 2024

California and most other coastlines around the world are being impacted by both long-term sea-level rise and short-term extreme events. Due to California’s long and intensively developed coastline, it is an important area for evaluating responses to these challenges. The predominant historic approach to coastal erosion in California and globally has been the construction of hard coastal armoring such as seawalls and rock revetments. The concept of living shorelines—defined as using natural elements like plants, sand, or rocks to stabilize the coastline—has been widely proposed as a soft or green response to coastal erosion and flooding. However, these approaches have very limited application in high-energy environments such as California’s 1100-mile-long outer coast and are not realistic solutions for protection from wave attack at high tides or long-term sea-level rise. Each of the state’s coastal communities need to identify their most vulnerable areas, develop adaptation plans, and plan eventual relocation strategies in response to an accelerating sea-level rise.
A Low-Cost and High-Precision Underwater Integrated Navigation System
Authors: Liu Jiapeng , Yu Te , Wu Chao , Zhou Chang , Lu Dihua , Zeng Qingshan
Published: January 2024

The traditional underwater integrated navigation system is based on an optical fiber gyroscope and Doppler Velocity Log, which is high-precision but also expensive, heavy, bulky and difficult to adapt to the development requirements of AUV swarm, intelligence and miniaturization. This paper proposes a low-cost, light-weight, small-volume and low-computation underwater integrated navigation system based on MEMS IMU/DVL/USBL. First, according to the motion formula of AUV, a five-dimensional state equation of the system was established, whose dimension was far less than that of the traditional. Second, the main source of error was considered. As the velocity observation value of the system, the velocity measured by DVL eliminated the scale error and lever arm error. As the position observation value of the system, the position measured by USBL eliminated the lever arm error. Third, to solve the issue of inconsistent observation frequencies between DVL and USBL, a sequential filter was proposed to update the extended Kalman filter. Finally, through selecting the sensor equipment and conducting two lake experiments with total voyages of 5.02 km and 3.2 km, respectively, the correctness and practicality of the system were confirmed by the results. By comparing the output of the integrated navigation system and the data of RTK GPS, the average position error was 4.12 m, the maximum position error was 8.53 m, the average velocity error was 0.027 m/s and the average yaw error was 1.41°, whose precision is as high as that of an optical fiber gyroscope and Doppler Velocity Log integrated navigation system, but the price is less than half of that. The experimental results show that the proposed underwater integrated navigation system could realize the high-precision and long-term navigation of AUV in the designated area, which had great potential for both military and civilian applications.
PSO-Based Predictive PID-Backstepping Controller Design for the Course-Keeping of Ships
Authors: Lin Bowen , Zheng Mao , Han Bing , Chu Xiumin , Zhang Mingyang , Zhou Haiming , Ding Shigan , Wu Hao , Zhang Kehao
Published: January 2024

Ship course-keeping control is of great significance to both navigation efficiency and safety. Nevertheless, the complex navigational conditions, unknown time-varying environmental disturbances, and complex dynamic characteristics of ships pose great difficulties for ship course-keeping. Thus, a PSO-based predictive PID-backstepping (P-PB) controller is proposed in this paper to realize the efficient and rapid course-keeping of ships. The proposed controller takes the ship’s target course, current course, yawing speed, as well as predictive motion parameters into consideration. In the design of the proposed controller, the PID controller is improved by introducing predictive control. Then, the improved controller is combined with a backstepping controller to balance the efficiency and stability of the control. Subsequently, the parameters in the proposed course-keeping controller are optimized by utilizing Particle Swarm Optimization (PSO), which can adaptively adjust the value of parameters in various scenarios, and thus further increase its efficiency. Finally, the improved controller is validated by carrying out simulation tests in various scenarios. The results show that it improves the course-keeping error and time-response specification by 4.19% and 9.71% on average, respectively, which can efficiently achieve the course-keeping of ships under various scenarios.
Experimental Study on Adaptive Backstepping Synchronous following Control and Thrust Allocation for a Dynamic Positioning Vessel
Authors: Liu Changde , Zhang Yufang , Gu Min , Zhang Longhui , Teng Yanbin , Tian Fang
Published: January 2024

Cargo transfer vessels (CTVs) are designed to transfer cargo from a floating production storage and offloading (FPSO) unit into conventional tankers. The dynamic positioning system allows the CTV to maintain a safe position relative to the FPSO unit using a flexible cargo transmission pipe, and the CTV tows the tanker during operating conditions. The operation mode can be considered a synchronization tracking control problem. In this paper, a synchronization control strategy is presented based on the virtual leader–follower configuration and an adaptive backstepping control method. The position and heading of the following vessel are proven to be able to globally exponentially converge to the virtual ship by the contraction theorem. Then, the optimization problem of the desired thrust command from the controller is solved through an improved firefly algorithm, which fully considers the physical characteristics of the azimuth thruster and the thrust forbidden zone caused by hydrodynamic interference. To validate the effectiveness of the presented synchronous following strategy and thrust allocation algorithm, a scale model experiment is carried out under a sea state of 4 in a seakeeping basin. The experimental results show that the CTV can effectively maintain a safe distance of 100 m with a maximum deviation of 3.78 m and an average deviation of only 0.99 m in the wave heading 180°, which effectively verifies that the control strategy proposed in this paper can achieve safe and cooperative operation between the CTV and the FPSO unit. To verify the advantages of the SAF algorithm in the thrust allocation, the SQP algorithm and PSO algorithm are used to compare the experimental results. The SAF algorithm outperforms the SQP and PSO algorithms in longitudinal and lateral forces, with the R-squared (R2) values of 0.9996 (yaw moment), 0.9878 (sway force), and 0.9596 (surge force) for the actual thrusts and control commands in the wave heading 180°. The experimental results can provide technical support to improve the safe operation of CTVs.
The Role of Smart Technologies in French Hospitals’ Branding Strategies
Authors: Medina Aguerrebere Pablo , Medina Eva , Gonzalez Pacanowski Toni
Published: January 2024

Hospitals resort to different initiatives to build their brands, including media relations, events, and marketing campaigns. However, they face several challenges related to legal frameworks, patients’ new demands, and hospitals’ digital transformation. This paper analyzes how the best hospitals in France manage smart technologies to enhance their relationships with stakeholders and reinforce their brands. We resorted to the World’s Best Hospitals 2023 to identify the 150 best hospitals in this country. Then, we defined 34 branding indicators to evaluate how each hospital managed smart technologies for branding purposes. We adapted these criteria to different platforms and targets: homepage (patients), online newsroom (media companies), About Us section (suppliers, shareholders, and public authorities), and artificial intelligence department (employees). When analyzing these criteria, we resorted to a binary system and only considered hospitals’ official websites. Our results proved that 98% of hospitals had a website, but not all respected the criteria related to the homepage (4.54 of 11), online newsroom (2.52 of 11), or About Us section (1.56 of 6). The best hospitals in France, according to the number of criteria respected, were Institut Curie-Oncology (20), Institut Gustave Roussy–Oncology (19), and Hôpital Paris Saint-Joseph (19). We concluded that French hospitals should implement collective branding processes that include all stakeholders, not just patients: media companies, public authorities, suppliers, shareholders, and employees. Moreover, these organizations should implement an in-house artificial intelligence department that leads a digital transformation from a medical, branding, and communication perspective. Finally, French hospitals’ branding efforts on smart platforms should focus more on content about the brand so that stakeholders understand the uniqueness of these organizations.
Temporal Interactions between Maintenance of Cerebral Cortex Thickness and Physical Activity from an Individual Person Micro-Longitudinal Perspective and Implications for Precision Medicine
Authors: Wall John , Xie Hong , Wang Xin
Published: January 2024

Maintenance of brain structure is essential for neurocognitive health. Precision medicine has interests in understanding how maintenance of an individual person’s brain, including cerebral cortical structure, interacts with lifestyle factors like physical activity. Cortical structure, including cortical thickness, has recognized relationships with physical activity, but concepts of these relationships come from group, not individual, focused findings. Whether or how group-focused concepts apply to an individual person is fundamental to precision medicine interests but remains unclear. This issue was studied in a healthy man using concurrent micro-longitudinal tracking of magnetic resonance imaging-defined cortical thickness and accelerometer-defined steps/day over six months. These data permitted detailed examination of temporal relationships between thickness maintenance and physical activity at an individual level. Regression analyses revealed graded significant and trend-level temporal interactions between preceding activity vs. subsequent thickness maintenance and between preceding thickness maintenance vs. subsequent activity. Interactions were bidirectional, delayed/prolonged over days/weeks, positive, bilateral, directionally asymmetric, and limited in strength. These novel individual-focused findings in some ways are predicted, but in other ways remain unaddressed or undetected, by group-focused work. We suggest that individual-focused concepts of temporal interactions between maintenance of cortical structure and activity can provide needed new insight for personalized tailoring of physical activity, cortical, and neurocognitive health.
Lack of Association of Acne Severity with Depression, Anxiety, Stress, and Eating Attitudes: A Cross-Sectional Study
Authors: Karaağaç Mustafa , Akça Hanife Merve , Acat Ömer
Published: January 2024

Background: this study aimed to investigate the relationship between acne severity and depression, anxiety, stress, and negative eating attitudes in patients with acne vulgaris. Method: This study was conducted with 81 patients with acne vulgaris who applied to the dermatology outpatient clinic of Karaman Training and Research Hospital. The patients were asked to complete a sociodemographic data form, the three-factor nutrition questionnaire (TFEQ-21), and the depression anxiety stress scale (DASS-21). Acne severity was assessed using the global acne grading system (GAGS) by an expert dermatologist. Results: Of the 81 patients, 74.1% were female and the average age of the cohort was 22.86 years. The average body mass index of the patients was 21.78 and the GAGS average score was 24.25. Correlation tests revealed the lack of any relationship between the GAGS score and the DASS-21 and TFEQ-21 scale scores (and their subscales). The DASS-21 depression subscale was correlated with the TFEQ-21 total score, and TFEQ-21 emotional eating and TFEQ-21 uncontrolled eating scores. Additionally, a relationship was identified between the DASS21-stress subscale score and TFEQ-21 uncontrolled Eating and TFEQ-21 total score, as well as between the DASS21-anxiety scale and the TFEQ-21 total score and TFEQ-21 uncontrolled eating subscale score. Conclusions: Although no relationship was found between acne severity and depression, anxiety, or eating disorders, these conditions can increase the risk of eating disorders among acne patients. Therefore, it is critical to take the necessary precautions for the treatment of depression and anxiety disorders in this patient population.
A Proposed Typology of Farming Systems for Assessing Sustainable Livelihood Development Pathways in the Tien Shan Mountains of Kyrgyzstan
Authors: Azarov Azamat , Sidle Roy C. , Darr Dietrich , Verner Vladimir , Polesny Zbynek
Published: January 2024

In Kyrgyzstan, most farming systems focus on animal husbandry, which depends on mixtures of crops and pastures around settlements and higher-elevation summer pastures. These farms face the problems of insufficient fodder production and pasture degradation due to overgrazing, resulting in low productivity of livestock and reduced household incomes. The spatial diversity of farms often hampers the development of interventions aimed at improving crop and animal productivity, as well as sustainable grassland management, while the absence of a comprehensive and systematic classification system that effectively encompasses the diverse range of livelihood strategies within farming systems presents a significant obstacle to the advancement of initiatives promoting sustainable livelihoods. This study aimed to develop a consistent typology of smallholder farms in the Tien Shan using multivariate analysis. By analyzing data from 235 farm-households and evaluating key classification variables, we identified two distinct farming systems, upper mountain farms and lower mountain farms, based on socioeconomic and agro-ecological characteristics. Our typology considers elevation, grazing period, cultivated area, and off-farm income and better captures the diversity of farming activities and household income compared to current classification models. These findings will inform and tailor policies and interventions suitable for enhancing sustainable livelihoods in Kyrgyzstan’s mountain farming systems.
Correction: Mazzini et al. Anatomical and Functional Outcomes after Endoresection and Adjuvant Ruthenium Brachytherapy for Uveal Melanoma: A Single-Center Experience. Life 2023, 13, 902
Authors: Mazzini Cinzia , Vicini Giulio , Di Leo Laura , Massi Daniela , Rizzo Stanislao , Giansanti Fabrizio
Published: January 2024

There was an error in the original publication [...]
Evaluation of Short-Term Clinical Effects of a Novel Repetitive Facilitation Exercise Training Program Using a Hemiplegic Elbow Extension Rehabilitation System
Authors: Taniguchi Koutaro , Yu Yong
Published: January 2024

Repetitive Facilitation Exercise (RFE) is known as an effective rehabilitation method that can elicit brain plasticity. In our previous study, we developed a hemiplegic upper limb rehabilitation system that can train the elbow and shoulder based on RFE theory. The system consists of a selective Arm-DoF constrainable mechanism and a multiple facilitative stimulus timing and duration control system. The selective Arm-DoF constrainable mechanism has three DoF, making it possible to selectively restrict a DoF of the shoulder or elbow. The multiple facilitative stimulation timing and duration control system only has an electrical stimulation source and a vibrator and no large actuators to perform the training exercise. In this study, we undertook an evaluation of the short-term clinical effects of a proposed elbow training program using the hemiplegic upper limb rehabilitation system. The training method consists of two sets, each involving 50 repetitions of the elbow extension exercise programmed in our system. We evaluated the short-term training effects through clinical trials for five stroke patients using the above method. In the evaluation, 10 repetitions of pre/post-tests without any facilitative stimulus were performed before and after the two sets of training. As a result, the maximum angular velocities or the average angular velocities of the elbow extensions improved significantly in most subjects. These results indicate that the quickness or the smoothness of elbow extension movements in the hemiplegic limb improved. Therefore, our clinical experiments support the short-term clinical benefits of the proposed method as well as the practicality of quantitative evaluation using our system.
A Frequency/Phase/Amplitude Estimator for Three-Phase Applications Operating at a Low Sampling Rate
Authors: Abusorrah Abdullah M. , Sepahvand Hamed
Published: January 2024

A frequency/phase/amplitude estimator is arguably one of the most crucial components in the control and synchronization of grid-connected equipment. Such an estimator may also be useful for monitoring and protection purposes in power systems. In this paper, an open-loop (and therefore unconditionally stable) estimator for the accurate and rapid extraction of the grid voltage phase, frequency, and amplitude is presented. In designing the proposed technique, special focus is given to applications operating at a low sampling rate. Examples of such applications include high-power converters, where both switching and sampling frequencies are very low. The study concludes with a comprehensive evaluation of the proposed estimator, demonstrating its effectiveness in accurately and swiftly estimating the fundamental parameters of grid voltage under low sampling rates. It highlights the estimator’s enhanced performance in scenarios of distorted grid conditions and its superiority in filtering capabilities compared to traditional methods. These findings underline the estimator’s potential for broad applicability in power system monitoring, protection, and control.
Relationship between Generalized Orthogonality and Gâteaux Derivative
Authors: Xu Peixuan , Ji Donghai , Zhang Hongxu
Published: January 2024

This paper investigates the relationship between generalized orthogonality and Gâteaux derivative of the norm in a normed linear space. It is shown that the Gâteaux derivative of x in the y direction is zero when the norm is Gâteaux differentiable in the y direction at x and x and y satisfy certain generalized orthogonality conditions. A case where x and y are approximately orthogonal is also analyzed and the value range of the Gâteaux derivative in this case is given. Moreover, two concepts are introduced: the angle between vectors in normed linear space and the ⊥Δ coordinate system in a smooth Minkowski plane. Relevant examples are given at the end of the paper.
The Resistance of Polyethersulfone Membranes on the Alkaline Cleaning Solutions
Authors: Gryta Marek , Woźniak Piotr
Published: January 2024

Polyethersulfone (PES) is a polymer popularly used to produce ultrafiltration (UF) membranes. PES is relatively hydrophobic; thus, hydrophilic ingredients are added to the membrane matrix to reduce the fouling intensity. Ingredients such as polyvinylpyrrolidone (PVP) reduce the resistance of PES to NaOH solutions. This study investigated the possibility of using PES membranes for the separation of alkaline cleaning solutions. For this purpose, self-made PES membranes and commercial ultrafiltration PES membranes (UE10—10 kDa and UE50—100 kDa) containing PVP additive were used. The membranes were soaked for 18 months in alkaline (pH = 11.3–11.5) solutions of car washing fluids. It has been found that long-term contact with these solutions caused changes in the structure of the surface layer, especially of membranes containing PVP. As a result, the separation of dextran (100–200 kDa) decreased by 30–40% for PES membranes, 30–40% for UE10 and 40–60% for UE50. Despite these changes, the separation efficiency (rejection of COD, NTU and anionic surfactants) of synthetic car wash wastewater (mixture of surfactants and hydrowax) was similar to the results obtained for pristine membranes.
The Role of Flagellum and Flagellum-Based Motility on Salmonella Enteritidis and Escherichia coli Biofilm Formation
Authors: Vilas Boas Diana , Castro Joana , Araújo Daniela , Nóbrega Franklin L. , Keevil Charles W. , Azevedo Nuno F. , Vieira Maria João , Almeida Carina
Published: January 2024

Flagellum-mediated motility has been suggested to contribute to virulence by allowing bacteria to colonize and spread to new surfaces. In Salmonella enterica and Escherichia coli species, mutants affected by their flagellar motility have shown a reduced ability to form biofilms. While it is known that some species might act as co-aggregation factors for bacterial adhesion, studies of food-related biofilms have been limited to single-species biofilms and short biofilm formation periods. To assess the contribution of flagella and flagellum-based motility to adhesion and biofilm formation, two Salmonella and E. coli mutants with different flagellar phenotypes were produced: the fliC mutants, which do not produce flagella, and the motAB mutants, which are non-motile. The ability of wild-type and mutant strains to form biofilms was compared, and their relative fitness was determined in two-species biofilms with other foodborne pathogens. Our results showed a defective and significant behavior of E. coli in initial surface colonization (p < 0.05), which delayed single-species biofilm formation. Salmonella mutants were not affected by the ability to form biofilm (p > 0.05). Regarding the effect of motility/flagellum absence on bacterial fitness, none of the mutant strains seems to have their relative fitness affected in the presence of a competing species. Although the absence of motility may eventually delay initial colonization, this study suggests that motility is not essential for biofilm formation and does not have a strong impact on bacteria’s fitness when a competing species is present.
Goldenseal (Hydrastis canadensis L.) Extracts Inhibit the Growth of Fungal Isolates Associated with American Ginseng (Panax quinquefolius L.)
Authors: Gao Ying , Swiggart Ethan , Wolkiewicz Kaela , Liyanapathiranage Prabha , Baysal-Gurel Fulya , Avin Farhat A. , Lopez Eleanor F. P. , Jordan Rebecca T. , Kellogg Joshua , Burkhart Eric P.
Published: January 2024

American ginseng, a highly valuable crop in North America, is susceptible to various diseases caused by fungal pathogens, including Alternaria spp., Fusarium spp., and Pestalotiopsis spp. The development of alternative control strategies that use botanicals to control fungal pathogens in American ginseng is desired as it provides multiple benefits. In this study, we isolated and identified three fungal isolates, Alternaria panax, Fusarium sporotrichioides, and Pestalotiopsis nanjingensis, from diseased American ginseng plants. Ethanolic and aqueous extracts from the roots and leaves of goldenseal were prepared, and the major alkaloid constituents were assessed via liquid chromatography–mass spectrometry (LC–MS). Next, the antifungal effects of goldenseal extracts were tested against these three fungal pathogens. Goldenseal root ethanolic extracts exhibited the most potent inhibition against fungal growth, while goldenseal root aqueous extracts and leaf ethanolic extracts showed only moderate inhibition. At 2% (m/v) concentration, goldenseal root ethanolic extracts showed an inhibition rate of 86.0%, 94.9%, and 39.1% against A. panax, F. sporotrichioides, and P. nanjingensis, respectively. The effect of goldenseal root ethanolic extracts on the mycelial morphology of fungal isolates was studied via scanning electron microscopy (SEM). The mycelia of the pathogens treated with the goldenseal root ethanolic extract displayed considerable morphological alterations. This study suggests that goldenseal extracts have the potential to be used as a botanical fungicide to control plant fungal diseases caused by A. panax, F. sporotrichioides, or P. nanjingensis.
Recent Progress in Photoelectrochemical Sensing of Pesticides in Food and Environmental Samples: Photoactive Materials and Signaling Mechanisms
Authors: Song Jie , Chen Yuqi , Li Ling , Tan Mingqian , Su Wentao
Published: January 2024

Pesticides have become an integral part of modern agricultural practices, but their widespread use poses a significant threat to human health. As such, there is a pressing need to develop effective methods for detecting pesticides in food and environmental samples. Traditional chromatography methods and common rapid detection methods cannot satisfy accuracy, portability, long storage time, and solution stability at the same time. In recent years, photoelectrochemical (PEC) sensing technology has gained attention as a promising approach for detecting various pesticides due to its salient advantages, including high sensitivity, low cost, simple operation, fast response, and easy miniaturization, thus becoming a competitive candidate for real-time and on-site monitoring of pesticide levels. This review provides an overview of the recent advancements in PEC methods for pesticide detection and their applications in ensuring food and environmental safety, with a focus on the categories of photoactive materials, from single semiconductor to semiconductor–semiconductor heterojunction, and signaling mechanisms of PEC sensing platforms, including oxidation of pesticides, steric hindrance, generation/decrease in sacrificial agents, and introduction/release of photoactive materials. Additionally, this review will offer insights into future prospects and confrontations, thereby contributing novel perspectives to this evolving domain.
Facilitators and Barriers to Receiving Palliative Care in People with Kidney Disease: Predictive Factors from an International Nursing Perspective
Authors: de Barbieri Ilaria , Strini Veronica , Noble Helen , Carswell Claire , Rocchi Marco Bruno Luigi , Sisti Davide
Published: January 2024

Background: Palliative care (PC) focuses on relieving pain and difficult symptoms rather than treating disease or delaying its progress. Palliative care views death as a natural process and allows patients to live the last phase of their existence in the best possible way, encouraging them to express their opinions and wishes for a good death. Interventions are advocated to control symptoms and distress and promote wellbeing and social functioning. A multidisciplinary approach to support patients receiving palliative care is encouraged. Objective: The aims of this study were to investigate the facilitators and barriers to PC in people with kidney disease from a nursing perspective and to explore predictive factors associated with nurse-perceived facilitators and barriers to PC in people with kidney disease. Design: This study is a survey that adopted a questionnaire created in 2021 with Delphi methology, which included 73 statements divided into 37 facilitators and 36 barriers to PC in patients with kidney disease, to be scored using a Likert scale. Participants and Measurements: Participants were obtained through the membership database of the European Dialysis and Transplant Nurses Association/European Renal Care Association (EDTNA/ERCA) of 2020. Inclusion criteria included being registered as a nurse, an EDTNA/ERCA member and understanding of the English language. The questionnaire was sent via email. Results: Three profiles of respondents were found: the first group was characterized by the highest agreement percentages of facilitators and with an average value of 53.7% in barriers; the second was characterized by a lower endorsement of facilitators and similar agreement to the first group for barriers; the third group had a high probability (>80%) of items endorsing both barriers and facilitators. Predictive variables were significantly associated with “Years in nephrology” and “macro geographic area”. Conclusions: This study demonstrates variation in PC practice across Europe. Some professionals identified fewer barriers to PC and appeared more confident when dealing with difficult situations in a patient’s care pathway, while others identified more barriers as obstacles to the implementation of adequate treatment. The number of years of nephrology experience and the geographical area of origin predicted how nurses would respond. This study was not registered.
Sensory, Affective, and Social Experiences with Haptic Devices in Intramural Care Practice
Authors: Vasseur Dianne , Ipakchian Askari Sima , Suijkerbuijk Sandra , Nap Henk Herman , IJsselsteijn Wijnand
Published: January 2024

Previous work has shown that technology can facilitate the communication of emotions, social touch, and social presence through haptic devices, meaning devices that provide a haptic stimulation. However, for special user groups living in long-term care facilities, such as people with dementia, the applications of these haptic devices are not apparent. The aim of this study is to understand how haptic devices can be used in intramural care facilities in times of social isolation, focusing on haptic devices that utilize haptic sensation. Five haptic devices were tested at three care facilities. Insights from this study highlight the potential of haptic devices to enhance sensory, affective, and social experiences during video calling between residents and their relatives. Moreover, the importance of the tactile sensation and form factor of haptic devices in the care context is addressed, along with insights on how to create the appropriate atmosphere during video calling.
Periodontitis and Alzheimer’s Disease: Is There a Connection?
Authors: Lundergan William , Parthasarathy Kavitha , Knight Navid
Published: January 2024

The oral health/systemic health connection has been an area of research interest that increased dramatically during the 1990s. Periodontal disease has been associated with a number of systemic conditions, including cardiovascular disease, diabetes, pre-term low-birth-weight infants, respiratory conditions, rheumatoid arthritis, cancer, and Alzheimer’s disease. Inflammation is the obvious link that connects periodontal disease with these conditions, but is this association casual or causal? We will address the biologic plausibility, evidence from human studies, evidence from animal studies, and therapeutic interventions as we review the current understanding of the link between periodontitis and Alzheimer’s disease.