bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Barite in the Post-Mining Stabilization of Radium-226: A Modeling Contribution for Sequential Extractions
Authors: Besançon Clémence , Chautard Camille , Beaucaire Catherine , Savoye Sébastien , Sardini Paul , Gérard Martine , Descostes Michael
Published: June 2020

Barite is ubiquitous and known to incorporate 226Ra through the formation of a solid-solution. In U mining mill tailings, barite is one of the dominant sulfate-binding minerals. In such environments, sequential extractions are generally used to identify the U- and 226Ra-binding phases and their associated reactivity. To better decipher the main processes governing the behavior of 226Ra during such sequential extractions, a geochemical model was developed with PHREEQC mimicking the sequential extraction of U and 226Ra from Bois-Noirs Limouzat U mine tailings, France. The model results were compared with a dataset produced by an experimental sequential extraction from the same mine tailings and including data on the solids and selective extraction results with the major elements, U and 226Ra. The simulations reproduced the results of the experimental chemical extractions accurately, with iron oxyhydroxides being the major U binding phase. However, the modeling indicated rather that barite would be the main 226Ra binding phase, instead of the iron oxyhydroxides identified by the experimental extractions. This is consistent with the 226Ra concentration measured in pore water, but in disagreement with the direct interpretation of the sequential extractions. The direct interpretation disregarded the role of barite in the geochemical behavior of 226Ra because barite was not specifically targeted by any of the extraction steps. However, the modeling showed that the dissolution of 226Ra-binding barite by reactants would lead to a 226Ra redistribution among the clay minerals, resulting in a skew in the experimental results. Similar results were achieved by referring simply to the bulk mineralogy of the tailings. This study highlights the importance of considering the mineralogy, mineral reactivity and retention capacity for more realistic interpretation of sequential extractions. Moreover, this paper provides new perspectives on the long-term consequences of these mill tailings in which barite controls the geochemical behavior of the 226Ra.
Optical Scattering of Liquid Gallium Nanoparticles Coupled to Thin Metal Films
Authors: Deng Fu , Liu Hongfeng , Peng Yuanyuan , Panmai Mingcheng , Lan Sheng
Published: June 2020

We investigate experimentally and numerically the scattering properties of liquid gallium nanoparticles coupled to a thin gold or silver film. The gallium nanoparticles are excited either directly by using inclined white light or indirectly by surface plasmon polaritons generated on the surface of the gold/silver film. In the former case, the scattering spectrum is always dominated by a scattering peak at ∼540 nm with a long-wavelength shoulder which is redshifted with increasing diameter of the gallium nanoparticle. Under the excitation of the surface plasmon polaritons, optical resonances with much narrower linewidths, which are dependent on the incidence angle of the white light, appear in the scattering spectra. In this case, the scattering spectrum depends weakly on the diameter of the gallium nanoparticle but the radiation pattern exhibits a strong dependence. In addition, a significant enhancement of electric field is expected in the gap region between the gallium nanoparticles and the gold film based on numerical simulation. As compared with the gallium nanoparticle coupled to the gold film which exhibit mainly yellow and orange colors, vivid scattering light spanning the visible light spectrum can be achieved in the gallium nanoparticles coupled to the silver film by simply varying the incidence angle. Gallium nanoparticles coupled to thin metal films may find potential applications in light–matter interaction and color display.
Olive Leaves as Biotemplates for Enhanced Solar-Light Harvesting by a Titania-Based Solid
Authors: Hidalgo-Carrillo Jesús , Martín-Gómez Juan , Herrera-Beurnio M. Carmen , Estévez Rafael C. , Urbano Francisco J. , Marinas Alberto
Published: June 2020

Olive leaves (by-product from olive oil production in olive mills) were used as biotemplates to synthesize a titania-based artificial olive leaf (AOL). Scanning electron microscopy (SEM) images of AOL showed the successful replication of trichomes and internal structure channels present in olive leaves. The BET surface area of AOL was 52 m2·g−1. X-ray diffraction (XRD) and Raman spectra revealed that the resulting solid was in the predominantly-anatase crystalline form (7.5 nm average particle size). Moreover, the synthesis led to a red-shift in light absorption as compared to reference anatase (gap energies of 2.98 and 3.2 eV, respectively). The presence of surface defects (as evidenced by X-ray photoelectron spectroscopy, XPS, and electron paramagnetic resonance spectroscopy, EPR) and doping elements (e.g., 1% nitrogen, observed by elemental analysis and XPS) could account for that. AOL was preliminarily tested as a catalyst for hydrogen production through glycerol photoreforming and exhibited an activity 64% higher than reference material Evonik P25 under solar irradiation and 144% greater under ultraviolet radiation (UV).
Nanomaterials and Nanotechnology-Associated Innovations against Viral Infections with a Focus on Coronaviruses
Authors: Nasrollahzadeh Mahmoud , Sajjadi Mohaddeseh , Soufi Ghazaleh Jamalipour , Iravani Siavash , Varma Rajender S.
Published: June 2020

Viral infections have recently emerged not only as a health threat to people but rapidly became the cause of universal fatality on a large scale. Nanomaterials comprising functionalized nanoparticles (NPs) and quantum dots and nanotechnology-associated innovative detection methods, vaccine design, and nanodrug production have shown immense promise for interfacing with pathogenic viruses and restricting their entrance into cells. These viruses have been scrutinized using rapid diagnostic detection and therapeutic interventional options against the caused infections including vaccine development for prevention and control. Coronaviruses, namely SARS-CoV, MERS-CoV, and SARS-CoV-2, have endangered human life, and the COVID-19 (caused by SARS-CoV-2) outbreak has become a perilous challenge to public health globally with huge accompanying morbidity rates. Thus, it is imperative to expedite the drug and vaccine development efforts that would help mitigate this pandemic. In this regard, smart and innovative nano-based technologies and approaches encompassing applications of green nanomedicine, bio-inspired methods, multifunctional bioengineered nanomaterials, and biomimetic drug delivery systems/carriers can help resolve the critical issues regarding detection, prevention, and treatment of viral infections. This perspective review expounds recent nanoscience advancements for the detection and treatment of viral infections with focus on coronaviruses and encompasses nano-based formulations and delivery platforms, nanovaccines, and promising methods for clinical diagnosis, especially regarding SARS-CoV-2.
The Effect of Heat Treatment on the Microstructure and Mechanical Properties of 2D Nanostructured Au/NiFe System
Authors: Zubar Tatiana , Fedosyuk Valery , Tishkevich Daria , Kanafyev Oleg , Astapovich Ksenia , Kozlovskiy Artem , Zdorovets Maxim , Vinnik Denis , Gudkova Svetlana , Kaniukov Egor , Sombra Antonio Sergio B. , Zhou Di , Jotania Rajshree B. , Singh Charanjeet , Trukhanov Sergei , Trukhanov Alex
Published: June 2020

Nanostructured NiFe film was obtained on silicon with a thin gold sublayer via pulsed electrodeposition and annealed at a temperature from 100 to 400 °C in order to study the effect of heat treatment on the surface microstructure and mechanical properties. High-resolution atomic force microscopy made it possible to trace stepwise evolving microstructure under the influence of heat treatment. It was found that NiFe film grains undergo coalescence twice—at ~100 and ~300 °C—in the process of a gradual increase in grain size. The mechanical properties of the Au/NiFe nanostructured system have been investigated by nanoindentation at two various indentation depths, 10 and 50 nm. The results showed the opposite effect of heat treatment on the mechanical properties in the near-surface layer and in the material volume. Surface homogenization in combination with oxidation activation leads to abnormal strengthening and hardening-up of the near-surface layer. At the same time, a nonlinear decrease in hardness and Young’s modulus with increasing temperature of heat treatment characterizes the internal volume of nanostructured NiFe. An explanation of this phenomenon was found in the complex effect of changing the ratio of grain volume/grain boundaries and increasing the concentration of thermally activated diffuse gold atoms from the sublayer to the NiFe film.
Anabolic Properties of Mixed Wheat-Legume Pasta Products in Old Rats: Impact on Whole-Body Protein Retention and Skeletal Muscle Protein Synthesis
Authors: Berrazaga Insaf , Salles Jérôme , Laleg Karima , Guillet Christelle , Patrac Véronique , Giraudet Christophe , Le Bacquer Olivier , Gueugneau Marine , Denis Philippe , Pouyet Corinne , Pion Angelique , Sanchez Phelipe , Boirie Yves , Micard Valérie , Walrand Stéphane
Published: June 2020

The mechanisms that are responsible for sarcopenia are numerous, but the altered muscle protein anabolic response to food intake that appears with advancing age plays an important role. Dietary protein quality needs to be optimized to counter this phenomenon. Blending different plant proteins is expected to compensate for the lower anabolic capacity of plant-based when compared to animal-based protein sources. The objective of this work was to evaluate the nutritional value of pasta products that were made from a mix of wheat semolina and faba bean, lentil, or split pea flour, and to assess their effect on protein metabolism as compared to dietary milk proteins in old rats. Forty-three old rats have consumed for six weeks isoproteic and isocaloric diets containing wheat pasta enriched with 62% to 79% legume protein (depending on the type) or milk proteins, i.e., casein or soluble milk proteins (SMP). The protein digestibility of casein and SMP was 5% to 14% higher than legume-enriched pasta. The net protein utilization and skeletal muscle protein synthesis rate were equivalent either in rats fed legume-enriched pasta diets or those fed casein diet, but lower than in rats fed SMP diet. After legume-enriched pasta intake, muscle mass, and protein accretion were in the same range as in the casein and SMP groups. Mixed wheat-legume pasta could be a nutritional strategy for enhancing the protein content and improving the protein quality, i.e., amino acid profile, of this staple food that is more adequate for maintaining muscle mass, especially for older individuals.
Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study
Authors: Arisawa Kokichi , Katsuura-Kamano Sakurako , Uemura Hirokazu , Van Tien Nguyen , Hishida Asahi , Tamura Takashi , Kubo Yoko , Tsukamoto Mineko , Tanaka Keitaro , Hara Megumi , Takezaki Toshiro , Nishimoto Daisaku , Koyama Teruhide , Ozaki Etsuko , Suzuki Sadao , Nishiyama Takeshi , Kuriki Kiyonori , Kadota Aya , Takashima Naoyuki , Ikezaki Hiroaki , Murata Masayuki , Oze Isao , Matsuo Keitaro , Mikami Haruo , Nakamura Yohko , Takeuchi Kenji , Wakai Kenji
Published: June 2020

The association between dietary acid load and metabolic syndrome (MetS) has not been fully investigated. A cross-sectional study was performed on 14,042 men and 14,105 women (aged 35–69 years) who participated in a baseline survey of the Japan Multi-Institutional Collaborative Cohort study. Dietary acid load was assessed using the net-endogenous-acid-production (NEAP) score that is closely correlated with the rate of renal net acid excretion. MetS was diagnosed according to the Joint Interim Statement Criteria of 2009 using body-mass index instead of waist circumference. After adjusting for potential confounders, higher NEAP scores were associated with a significantly increased odds ratio (OR) of MetS, obesity, high blood pressure, and high fasting blood glucose. These associations remained significant after further adjustment for carbohydrate intake or two nutrient-pattern scores significantly associated with MetS. After adjustment for fiber, iron, potassium, and vitamin pattern scores, the OR of MetS for the highest quartile of NEAP scores, relative to the lowest quartile, was 1.25 (95% confidence interval 1.12–1.39). There was no significant interaction between sex, age, or body-mass index and NEAP. Higher dietary acid load was associated with a higher prevalence of MetS and several of its components, independently of carbohydrate intake or nutrient patterns.
Sources, Production, and Clinical Treatments of Milk Fat Globule Membrane for Infant Nutrition and Well-Being
Authors: Fontecha Javier , Brink Lauren , Wu Steven , Pouliot Yves , Visioli Francesco , Jiménez-Flores Rafael
Published: June 2020

Research on milk fat globule membrane (MFGM) is gaining traction. The interest is two-fold; on the one hand, it is a unique trilayer structure with specific secretory function. On the other hand, it is the basis for ingredients with the presence of phospho- and sphingolipids and glycoproteins, which are being used as food ingredients with valuable functionality, in particular, for use as a supplement in infant nutrition. This last application is at the center of this Review, which aims to contribute to understanding MFGM’s function in the proper development of immunity, cognition, and intestinal trophism, in addition to other potential effects such as prevention of diseases including cardiovascular disease, impaired bone turnover and inflammation, skin conditions, and infections as well as age-associated cognitive decline and muscle loss. The phospholipid composition of MFGM from bovine milk is quite like human milk and, although there are some differences due to dairy processing, these do not result in a chemical change. The MFGM ingredients, as used to improve the formulation in different clinical studies, have indeed increased the presence of phospholipids, sphingolipids, glycolipids, and glycoproteins with the resulting benefits of different outcomes (especially immune and cognitive outcomes) with no reported adverse effects. Nevertheless, the precise mechanism(s) of action of MFGM remain to be elucidated and further basic investigation is warranted.
Synergistic Effect of Eugenol and Probiotic Lactobacillus Plantarum Zs2058 against Salmonella Infection in C57bl/6 Mice
Authors: Song Fanfen , Liu Junsheng , Zhao Wenyu , Huang Hongxuan , Hu Diangeng , Chen Haiqin , Zhang Hao , Chen Wei , Gu Zhennan
Published: June 2020

Previously, we showed the preventive effects of Lactobacillus plantarum ZS2058 (ZS2058) on Salmonella infection in murine models. In this work, we found that eugenol has a selective antibacterial effect, which inhibited Salmonella more than probiotics ZS2058 in vitro. It suggested a synergistic effect of them beyond their individual anti-Salmonella activity. We verified the conjecture in murine models. The results showed that the combination of ZS2058 and eugenol (CLPZE) significantly increased (p = 0.026) the survival rate of Salmonella-infected mice from 60% to 80% and the effect of CLPZE on preventing Salmonella-infection was 2-fold that of ZS2058 alone and 6-fold that of eugenol alone. CLPZE had a synergistic effect on inhibiting ST growth (the coefficient drug interaction ((CDI) = 0.829), reducing its invasiveness (CDI = 0.373) and downregulating virulence genes’ expression in vitro. CLPZE helped the host form a healthier gut ecosystem. CLPZE also elicited a stronger and earlier immune response to systemic infection. In conclusion, these obtained results suggest that ZS2058 and eugenol have a synergistic effect on preventing Salmonella infection and open new perspectives in the strategies of controlling the prevalence of Salmonella by combination of probiotics and functional food components.
Of Mice and Men: The Effect of Maternal Protein Restriction on Offspring’s Kidney Health. Are Studies on Rodents Applicable to Chronic Kidney Disease Patients? A Narrative Review
Authors: Torreggiani Massimo , Fois Antioco , D’Alessandro Claudia , Colucci Marco , Orozco Guillén Alejandra Oralia , Cupisti Adamasco , Piccoli Giorgina Barbara
Published: June 2020

In the almost 30 years that have passed since the postulation of the “Developmental Origins of Health and Disease” theory, it has been clearly demonstrated that a mother’s dietary habits during pregnancy have potential consequences for her offspring that go far beyond in utero development. Protein malnutrition during pregnancy, for instance, can cause severe alterations ranging from intrauterine growth retardation to organ damage and increased susceptibility to hypertension, diabetes mellitus, cardiovascular diseases and chronic kidney disease (CKD) later in life both in experimental animals and humans. Conversely, a balanced mild protein restriction in patients affected by CKD has been shown to mitigate the biochemical derangements associated with kidney disease and even slow its progression. The first reports on the management of pregnant CKD women with a moderately protein-restricted plant-based diet appeared in the literature a few years ago. Today, this approach is still being debated, as is the optimal source of protein during gestation in CKD. The aim of this report is to critically review the available literature on the topic, focusing on the similarities and differences between animal and clinical studies.
Generation of Stable cisPt Resistant Lung Adenocarcinoma Cells
Authors: Ruprecht Nico , Hofmann Lukas , Hungerbühler Martin Nils , Kempf Christoph , Heverhagen Johannes Thomas , von Tengg-Kobligk Hendrik
Published: June 2020

Platinum compounds represent the backbone of combined chemotherapy protocols for advanced lung cancer. The mechanisms responsible for its frequent primary or acquired resistance to cisplatin (cisPt)-based chemotherapy remains enigmatic. The availability of two cell lines of the same origin, one resistant and the other sensitive, will facilitate research to reveal the mechanism of resistance formation. Lung adenocarcinoma cells, A240286S (A24), were cultivated in increasing cisPt concentrations over a prolonged time. After a significant increase in IC50 was measured, cultivation of the cells was continued in absence of cisPt and IC50s determined over a long period (>7 months). As a result, a cell line with lasting, high-level cisPt resistance, designated (D-)A24cisPt8.0, was obtained. The cells were cross-resistant to oxaliplatin and to pemetrexed at a low level. Previous publications have claimed that Leucine-rich repeat-containing protein 8 (LRRC8A and LRRC8D) of the volume-regulated anion channels (VRACs) affect cellular resistance to cisPt. Even though cisPt decreased LRRC8D expression levels, we showed by knockdown and overexpression experiments with LRRC8A and D that these proteins do not govern the observed cisPt resistance. The tumor cell sublines described here provide a powerful model to study the mechanisms of resistance to cisPt in lung cancer cells and beyond.
“The Hour of Woman” and Edith Stein: Catholic New Feminist Responses to Essentialism
Authors: Köhler-Ryan Renée
Published: June 2020

This article examines how Edith Stein’s philosophical and theological anthropology is foundational to the “new feminism” that both Paul VI and John Paul II called for in the wake of the Second Vatican Council. In particular, this article shows how Stein helps to respond to Simone de Beauvoir’s argument that taking women’s biology into consideration leads to essentialism with political implications. This article outlines main themes in the new feminism, and gives a brief overview of the ideas about the “hour of woman” and the “feminine genius” pronounced by popes Paul VI and John Paul II. This article then describes and analyzes Stein’s psycho-physical theory of the human person. Finally, this article considers the importance of Stein’s thought for feminist theology, with brief application to the issue of the ordination of women to the priesthood.
Invisible QCD as Dark Energy
Authors: Addazi Andrea , Alexander Stephon , Marcianò Antonino
Published: June 2020

We account for the late time acceleration of the Universe by extending the Quantum Chromodynamics (QCD) color to a S U ( 3 ) invisible sector (IQCD). If the Invisible Chiral symmetry is broken in the early universe, a condensate of dark pions (dpions) and dark gluons (dgluons) forms. The condensate naturally forms due to strong dynamics similar to the Nambu–Jona-Lasinio mechanism. As the Universe evolves from early times to present times the interaction energy between the dgluon and dpion condensate dominates with a negative pressure equation of state and causes late time acceleration. We conclude with a stability analysis of the coupled perturbations of the dark pions and dark gluons.
Human Cytomegalovirus-Encoded G Protein-Coupled Receptor UL33 Facilitates Virus Dissemination via the Extracellular and Cell-to-Cell Route
Authors: van Senten Jeffrey R. , Bebelman Maarten P. , van Gasselt Puck , Bergkamp Nick D. , van den Bor Jelle , Siderius Marco , Smit Martine J.
Published: June 2020

Human cytomegalovirus (HCMV) encodes four G protein-coupled receptor (GPCR) homologs. Three of these receptors, UL78, US27 and US28, are known for their roles in HCMV dissemination and latency. Despite importance of its rodent orthologs for viral replication and pathogenesis, such a function is not reported for the HCMV-encoded GPCR UL33. Using the clinical HCMV strain Merlin, we show that UL33 facilitates both cell-associated and cell-free virus transmission. A UL33-deficient virus derivative revealed retarded virus spread, formation of less and smaller plaques, and reduced extracellular progeny during multi-cycle growth analysis in fibroblast cultures compared to parental virus. The growth of UL33-revertant, US28-deficient, and US28-revertant viruses were similar to parental virus under multistep growth conditions. UL33- and US28-deficient Merlin viruses impaired cell-associated virus spread to a similar degree. Thus, the growth defect displayed by the UL33-deficient virus but not the US28-deficient virus reflects UL33’s contribution to extracellular transmission. In conclusion, UL33 facilitates cell-associated and cell-free spread of the clinical HCMV strain Merlin in fibroblast cultures.
Antibody Neutralization of an Influenza Virus that Uses Neuraminidase for Receptor Binding
Authors: Gentles Lauren E. , Wan Hongquan , Eichelberger Maryna C. , Bloom Jesse D.
Published: June 2020

Influenza virus infection elicits antibodies against the receptor-binding protein hemagglutinin (HA) and the receptor-cleaving protein neuraminidase (NA). Because HA is essential for viral entry, antibodies targeting HA often potently neutralize the virus in single-cycle infection assays. However, antibodies against NA are not potently neutralizing in such assays, since NA is dispensable for single-cycle infection. Here we show that a modified influenza virus that depends on NA for receptor binding is much more sensitive than a virus with receptor-binding HA to neutralization by some anti-NA antibodies. Specifically, a virus with a receptor-binding G147R N1 NA and a binding-deficient HA is completely neutralized in single-cycle infections by an antibody that binds near the NA active site. Infection is also substantially inhibited by antibodies that bind NA epitopes distant from the active site. Finally, we demonstrate that this modified virus can be used to efficiently select mutations in NA that escape antibody binding, a task that can be laborious with typical influenza viruses that are not well neutralized by anti-NA antibodies. Thus, viruses dependent on NA for receptor binding allow for sensitive in vitro detection of antibodies binding near the catalytic site of NA and enable the selection of viral escape mutants.
Reporter Replicons for Antiviral Drug Discovery against Positive Single-Stranded RNA Viruses
Authors: Fernandes Rafaela S. , Freire Marjorie C. L. C. , Bueno Renata V. , Godoy Andre S. , Gil Laura H. V. G. , Oliva Glaucius
Published: June 2020

Single-stranded positive RNA ((+) ssRNA) viruses include several important human pathogens. Some members are responsible for large outbreaks, such as Zika virus, West Nile virus, SARS-CoV, and SARS-CoV-2, while others are endemic, causing an enormous global health burden. Since vaccines or specific treatments are not available for most viral infections, the discovery of direct-acting antivirals (DAA) is an urgent need. Still, the low-throughput nature of and biosafety concerns related to traditional antiviral assays hinders the discovery of new inhibitors. With the advances of reverse genetics, reporter replicon systems have become an alternative tool for the screening of DAAs. Herein, we review decades of the use of (+) ssRNA viruses replicon systems for the discovery of antiviral agents. We summarize different strategies used to develop those systems, as well as highlight some of the most promising inhibitors identified by the method. Despite the genetic alterations introduced, reporter replicons have been shown to be reliable systems for screening and identification of viral replication inhibitors and, therefore, an important tool for the discovery of new DAAs.
Peran Manajemen dalam Mengembangkan Pelayanan di Gereja
Authors: Parhusip Akdel
Published: May 2020

Penelitian ini merupakan penelitian kualitatif terhadap pentingnya menerapkan manajemen dalalm mengembangkan pelayanan di gereja, khususnya di Gereja Pentakosta Indonesia wilayah Pematangsiantar, Sumatra Utara.
Konstruksi Teologis Gereja Digital: Sebuah Refleksi Biblis Ibadah Online di Masa Pandemi Covid-19
Authors: Dwiraharjo Susanto
Published: May 2020

The internet has in fact become one with today's life. Not only has his presence changed many things in the fabric of social life, but it has also changed religious behavior. The worship behavior that has been limited by time and space, and that has become a standard for one's faith, is no longer the case. Not only related to the space and time of worship, even more than that the liturgy of the church that has been sacred has also changed. The output of writing this article is to find a formulation of the digital church. This study applies a qualitative method with phenomenological analysis. With this method, the scattered data can then be constructed in a more meaningful and easily understood theme. This research was conducted through 4 processes, namely: first describing facts based on data, second conducting an analysis of the facts found, third conducting a study of the topic from the standpoint of Christianity, and fourth finding its relevance in digital worship patterns.AbstrakInternet pada faktanya telah menyatu dengan kehidupan masa kini. Keha-dirannya tidak saja telah mengubah banyak hal dalam tatanan kehidupan sosial, tetapi juga telah mengubah perilaku keagamaan. Perilaku ibadah yang selama ini terbatasi oleh ruang dan waktu, dan itu telah dijadikan standar baku keimanan seseorang, sekarang tidak lagi demikian. Bukan saja terkait dengan ruang serta waktu peribadatan, bahkan lebih dari itu liturgi gereja yang selama ini disakralkan pun juga ikut berubah.  Luaran dari penulisan artikel ini adalah untuk menemukan sebuah formulasi ten-tang gereja digital. Penelitian ini menerapkan metode kualtatif dengan analisis fenomenologi. Dengan metode ini akan dapat ditemukan data-data yang terserak selanjutnya dikonstruksikan dalam satu tema yang lebih bermakna dan mudah dipahami. Penelitian ini dilakukan melalui 4 proses, yaitu: pertama mendiskripsikan fakta berdasarkan data, kedua me-lakukan analisis terhadap fakta yang ditemukan, ketiga melakukan kajian terhadap topik dari sudut pandang ajaran Kekristeenan, dan keempat me-nemukan relevansinya pada pola peribadatan secara digital.
Pengaruh Pemahaman Hidup Kudus Menurut 1 Tesalonika 4:1-8 terhadap Perilaku Seksual Remaja-Pemuda GPdI di Wilayah Sentani Timur Tengah
Authors: Fretes Priskila De
Published: May 2020

This study aims to determine whether there is an influence of understanding of holy life according to 1 Thessalonians 4: 1-8 on the sexual behavior of GPdI youth/adolescents in the South East Sentani Region, to find out which dimensions affect the understanding of holy life according to 1 Thessalonians 4: 1-8 towards sexual behavior of youth/adolescents in GPdI Sentani Middle East Region, and to find out which background factors have the most influence on sexual behavior in youth/adolescents in GPdI Sentani Middle East Region. In this study the population was youth/adolescents in the Middle East Sentani Region GPdI totaling 123 people. This research will use a quantitative (positivist) approach. The research method used is a quantitative research design with a survey method, which is explanatory-confirmatory. The data collection methods and tools used in this study are questionnaire methods. Normality test shows the probability value 0.32> 0.05, then the data distribution proved normal. ANOVA test or F test, Fcount of 724.395 with sig. = 0.000 <0.05 means that the relationship between variables X with Y is positive. Simple linear regression test results through the SPSS 20.0 for Windows program, obtained a simple regression equation that is equal to = Y = -47,727 + 0.864X. This shows that there is a positive influence. Hypothesis test results, understanding of holy life according to 1 Thess. 4: 1-8 (X) has a positive effect on the sexual behavior of GPdI youth/adolescents in Sentani Middle East (Y). This is indicated by the value of t arithmetic (26,915)> t table (1,979) which means that Ho is rejected and Ha is accepted.
STUDY OF THE EFFECT OF PARTICULATE ADDITIVES ON THE SETTING TIME AND MICROSTRUCTURE OF HIGH-ALUMINA CEMENT
Authors: Gavshina O. , Yashkina S. , Yashkin A. , Doroganov V. , Moreva I.
Published: June 2020

the paper is devoted to a full-scale study of corundum modifying dispersed additives (reactive, tabular, dispersing alumina) and artificial ceramic binder, their impact on high-alumina cement microstructure and setting time. Artificial ceramic binders are characterized by similar chemical, phase and grain composition with modifying corundum additives and characterized by the presence of particles less than 100 nm (up to 0.5%). The studied materials are finely dispersed polyfractional systems from 0.1 to 13 μm with a prevailing grading fraction of 2-10 μm. In this case, dispersing and reactive alumina are more coarse. Using the microscopy method it was established that the corundum additives increase packing density of high-alumina cement samples, especially with artificial ceramic binder addition. Studies of dispersed additives effect on the setting time of cement was conducted. It is established that the adding of artificial ceramic binder or dispersing alumina at 0.5% is speeding up the initial setting, but a further increasing of the additive content does not affect this indicator. The maximum reduction of setting time is caused by the introduction of 5% tabular alumina.
COMPOSITE BINDING MINERAL ADDITIVE INFLUENCE ON THE PLASTICIZER EFFICIENCY
Authors: Elistratkin M. , Minakov S. , Shatalova S.
Published: June 2020

replacing portland cement with composite binders in many construction spheres is becoming increasingly reasonable. A prerequisite for this is the ability to provide the binder with set of properties necessary for the most effective implementation of a particular practical task at minimum expense. Such optimization allows in some cases to achieve higher performance than the original cement, in others – to form new properties of the material, as well as provide direct or indirect savings of various resources. One of the most important parameters determining the strength characteristics of composites and their durability is the used binder water requirement. Furthermore in some cases the mixture must have certain rheological characteristics. Various types and generations plasticizing and water reducing additives are widely used to regulate these parameters. The article discusses relation of fine components electrosurface properties – the clinker component and various genetic types mineral additives for the main types of plasticizers magnitude diluting effect. The basic mechanisms and regularities are described, recommendations that allow to optimize the consumption of expensive additives or increasing their effectiveness in solving various practical problems are formulated.
Comparison between Threshold of Bitterness Perception and Blood Pressure for Resident Health Examination in Yakumo Town
Authors: Katayama Naomi
Published: May 2020

Japan is a super-aged society. Malnutrition, sarcopenia, and flail in the elderly are problems.It has also reported that abnormal olfaction and taste (function decline) occur as an early symptom of Alzheimer’s dementia. Taste and smell have a close relationship with appetite.It is need to study the provision of meals that enhance and the combination of foods from the middle age to the elderly. Because Alzheimer’s dementia gradually progresses from the middle-ages, and symptoms spear after becoming an older adult. For 16 years, we have conducted research on taste and olfaction in Yakumo town in Hokkaido, Japan, Where the population does not move much. In this report, we report on the results of the taste test using TASTDISC (Bitterness) in 2019 at Yakumo Town Resident Examination, which has been ongoing since 2007.
Odour Identification in Older Adults: Evidence from the Yakumo (2019)- Results by Gender and Age
Authors: Katayama Naomi
Published: May 2020

An examination of taste and olfactometry in Yakumo-Cho inhabitants’ examination carried out in 2005, and the result reported in Academia Journal of Medicinal Plants 2018. This study examined olfactory function. A personal function test is calculated from the Yakumo study database, and the odor stick identification tests administered to healthy older adults. The participants were community dwellers who voluntarily participated in the Yakumo Study and had managed everyday life by themselves. The participants were engaged in a variety of jobs, not only white-collar but also agriculture, fishery,and forestry. Therefore, the city regarded as a representative of today's Japanese society. From the database, 298 participants (169 females and 129 males) were selected form data in August, 2019. The Odor Stick Identification Test (OSIT-J) was used to assess odor perception. The aromas used in the OSIT-J include curry, perfume, Japanese cypress, India ink, menthol, rose, wood, Smelly socks/ sweat, fried garlic, condensed milk, gas for cooking, and Japanese mandarin aromas.
Comparison between Threshold of Sourness Perception and Blood Pressure for Resident Health Examination in Yakumo Town
Authors: Katayama Naomi
Published: May 2020

Since Japan is a super-aged society, various problems are occurring for the elderly. The nutritional problems of the elderly are complex, and measures currently took to solve the one by focusing on malnutrition–related items.Therefore, in this study, we focused on the sourness, which can identify the spoilage of food and could be expected to reduce salt.For 16 years, we have conducted research on taste and olfaction in Yakumo town in Hokkaido, Japan, Where the population does not move much. In this report, we report on the results of the taste test using TASTDISC (Sourness) in 2019 at Yakumo Town Resident Examination, which has been ongoing since 2007. From the database, 298 participants (169 females and 129 males) were selected form data in August 2019.
MOTIF PENGGUNAAN MEDIA SOSIAL BAGI PENYANDANG DISABILITAS NETRA (STUDI KASUS MENGENAI MOTIF PENGGUNAAN FACEBOOK BAGI PENYANDANG DISABILITAS NETRA PADA TERAPIS PIJAT)
Authors: Ladipa Claudino , Aristi Nindi
Published: June 2020

Penelitian ini bertujuan untuk mendeskripsikan motif kalangan disabilitas netra mempresentasikan dirinya melalui Facebook. Metode yang digunakan dalam penelitian ini adalah metode kualitatif dengan menggunakan pendekatan studi kasus. Wawancara mendalam dan pengamatan dilakukan kepada 9 informan yang terdiri dari pengguna facebook penyandang disabilitas netra, pengguna Facebook kalangan non-disabilitas, pemilik usaha Enso Rileksology dan Koordinator lapangan Enso Rileksology Hasil penelitian menujukkan motif dari penyandang disabilitas netra dalam mempresentasikan dirinya secara virtual melalui Facebook adalah untuk memperoleh hiburan dan membangun relasi motif tersebut digunakan untuk memperoleh hiburan ditengah kondisi pengelihatan yang terbatas, minimnya aktivitas untuk bersosialisasi dan memperoleh hiburan melalui aktivitas yang mebutuhkan mobilitas yang tinggi membuat penyandang disabilitas netra membutuhkan medium lain untuk bersosialisasi dan memperoleh hiburan melalui media sosial khususnya Facebook.
STRATEGI BRANDING IDENTITY @SITUGUNUNGSUSPENSIONBRIDGE DI KAB SUKABUMI UNTUK MENINGKATKAN PARIWISATA
Authors: Rahayu Hilda Sri , Dida Susanne , Setianti Yanti
Published: June 2020

Penelitian ini dilakukan pada objek wisata situ gunung suspension bridge. tujuan penelitian adalah bagaiamana strategi brand identity yang dilakukan oleh situ gunung melalu media sosial Instagram di akun @situgunungsuspensionbridege dalam menarik wisatawan, serta bagaimana strategi yang dilakukan oleh akun media sosial situ gunung melalui brand identity wisata ini menjadi simbol daya tarik untuk para wisatawan, penelitian ini dilakukan untuk melihat pembentukan brand idenitity yang ada di media sosial instagram terhadap kunjungan wisatawan penulis ingin mengetahui keadaan dari segi perusahaan dan juga dari stakeholder. Metode penelitian yang digunakan dalam penelitian ini adalah kualitatif deskriptif dengan metode studi kasus. Hasil penelitian menunjukan bahwa strategi brand identity di media sosial Instagram @situgunungsuspensionbridge dari yaitu Humas situ gunung yang melakukan pendekatan dengan pemangku kepentingan yaitu Kementerian Lingkungan Hidup dan Kehutanan strategi branding identity yang dilakukan untuk membuat masyarakat yang ada di sekitar Kab Sukabumi serta masyarakat yang ada di lndonesia mengunjungi objek wisata baru branding identity yang dimplementasikan dan dievaluasi dengan baik.
IMPLEMENTASI SUPPORT VECTOR MACHINE PADA PREDIKSI HARGA SAHAM GABUNGAN (IHSG)
Authors: Patriya Eka
Published: June 2020

Saham adalah instrumen pasar keuangan yang banyak dipilih oleh investor sebagai alternatif sumber keuangan, akan tetapi saham yang diperjual belikan di pasar keuangan sering mengalami fluktuasi harga (naik dan turun) yang tinggi. Para investor berpeluang tidak hanya mendapat keuntungan, tetapi juga dapat mengalami kerugian di masa mendatang. Salah satu indikator yang perlu diperhatikan oleh investor dalam berinvestasi saham adalah pergerakan Indeks Harga Saham Gabungan (IHSG). Tindakan dalam menganalisa IHSG merupakan hal yang penting dilakukan oleh investor dengan tujuan untuk menemukan suatu trend atau pola yang mungkin berulang dari pergerakan harga saham masa lalu, sehingga dapat digunakan untuk memprediksi pergerakan harga saham di masa mendatang. Salah satu metode yang dapat digunakan untuk memprediksi pergerakan harga saham secara akurat adalah machine learning. Pada penelitian ini dibuat sebuah model prediksi harga penutupan IHSG menggunakan algoritma Support Vector Regression (SVR) yang menghasilkan kemampuan prediksi dan generalisasi yang baik dengan nilai RMSE training dan testing sebesar 14.334 dan 20.281, serta MAPE training dan testing sebesar 0.211% dan 0.251%. Hasil penelitian ini diharapkan dapat membantu para investor dalam mengambil keputusan untuk menyusun strategi investasi saham.
Gen İdentifikasyonu ve DNA Kütüphanelerinin Oluşturulması
Authors: ÖZ Gülseren Yıldız , ALTUNOK Vahdettin
Published: May 2020

Genetik çalışmalar 1865 yılında Gregor Mendel tarafından başlatılmıştır. Günümüzde de tüm dünyada bilimadamları tarafından büyük bir hızla devam ettirilmektedir. Genetik bir çalışma, üzerinde çalışılacak gen bölgesininizolasyonu ile başlamaktadır. Bir gen bir kere izole edildikten sonra o gen üzerinde yapılacak işlemlerin sınırı yoktur.DNA ve RNA düzeyinde yapılan genetik çalışmalarda, genler tek başına ya da genlerin birbirleri ile olan etkileşimleriincelenerek tedavi yöntemleri geliştirilmeye çalışılmaktadır. Bilim adamları, izole edilen genler veya DNA parçalarıiçin saklama yöntemleri araştırmaktadır. Bu yöntemlerden biri de DNA kütüphanesi oluşturmaktır. DNA kütüphanelerininkurulmasıyla, kütüphanelerdeki kitaplar gibi DNA koleksiyonu ve deposunun oluşturulması amaçlanmaktadır.DNA kütüphaneleri; kanserde, nöroloji ve göz hastalıkları gibi alanlarda gen tedavisi çalışmalarında kullanılmaktadır.Ayrıca, rekombinant ilaçların bulunmasında, besin maddesi olarak ihtiyaç duyulan bazı proteinlerin üretilmesinde, çeşitligenlerin moleküler düzeyde tanımlandığı biyoteknolojik çalışmalarda, gen izolasyonu ve DNA kütüphanesi oluşturmayöntemine başvurulmaktadır.
Burdur Halk Pazarlarından Toplanan Beyaz Peynirlerde Patojen Candida spp. Varlığının Belirlenmesi
Authors: YURDAKUL Özen , KEYVAN Erhan , ERSOY Tuğba
Published: May 2020

Mayalar, gıdaların kalite ve güvenliğini etkileyen gıda endüstrisi için oldukça önemli mikroorganizmalar olup gıdalarda bozulmalara yol açabilirler. Candida türleri hastane enfeksiyonlarında önemli bir yere sahip iken son yıllarda gıdalar vasıtasıyla da insanlara bulaşabilmektedir. Bu çalışma ile halk pazarlarından toplanan peynirlerde patojen Candida türlerinin varlığının araştırılması amaçlandı. Analiz edilen 100 adet peynir örneğinin 84 (%84)’ünde patojen Candida spp. pozitif olarak bulundu ancak hiçbirinde C. albicans saptanamadı. Bu çalışmada API 20 C AUX Test Kit’i ile 103 adet izolatın tür ayrımı yapıldı. Elde edilen test kit sonuçlara göre izolatların %14’ü C. krusei, %5’i C. tropicalis olarak identifiye edildi. Gıda örneklerinin mikrobiyolojik incelemesinde toplam maya ve küf sayısı ile birlikte patojen mayaların varlığına yönelik analizlerin de yapılması toplum sağlığı açısından yararlı olacağı sonucuna varıldı.
Escherichia coli Patotiplerinin Virülens Faktörleri
Authors: OMEROVİC Mehmed , MÜŞTAK H. Kaan , KAYA İnci Başak
Published: May 2020

p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px 'Times New Roman'; min-height: 15.0px}

p.p2 {margin: 0.0px 0.0px 4.0px 19.0px; text-align: justify; line-height: 9.1px; font: 9.0px 'Times New Roman'}

span.s1 {font: 12.0px 'Times New Roman'}

 Escherichia coli, Enterobacteriaceae ailesinde yer alan Gram negatif, fakültatif anaerob, hareketli, spor oluşturmayan çomak şeklinde bir bakteridir. Patojenik E. coli’ler oluşturduğu hastalığın türüne ve sahip olduğu virulens özelliklerine göre sınıflandırılmaktadır. E. coli suşları bağırsak dışı enfeksiyonlara (ekstraintestinal) ve bağırsak enfeksiyonlarına (intestinal) neden olanlar olarak ikiye ayrılmaktadır. Diyarejenik E. coli patotipleri; enterotoksijenik E. coli, enteropatojenik E. coli, Vero- veya Shiga-toksin üreten E. coli, enterohemorajik E. coli, enteroagregatif E. coli, enteroinvaziv E. coli ve diffuz aderent E. coli’dir. Ekstraintestinal patojenik E. coli’ler; septisemik patojenik E. coli, üropatojenik E. coli, avian patojenik E. coli, meme patojenik E. coli ve rahim enfeksiyonlarına neden olanlar, endometriyal patojenik E. coli’dir. Bu makalede, yukarıda adı geçen patotiplerin virulens faktörleri ve bu virulens faktörlerin hastalık oluşumundaki rollerinden bahsedilmiştir. 
Etsiz Çiğ Köftelerde Patojen Candida spp. Varlığının Tespiti
Authors: YURDAKUL Özen Kurşun , KEYVAN Erhan , KIRDAR Seval Sevgi
Published: May 2020

p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px 'Times New Roman'; min-height: 15.0px}

p.p2 {margin: 0.0px 0.0px 4.0px 19.0px; text-align: justify; line-height: 9.1px; font: 9.0px 'Times New Roman'}

span.s1 {font: 12.0px 'Times New Roman'}

 Çiğ köfte, pişirilmeden tüketilen geleneksel hazır bir gıdadır. Artan tüketici taleplerinin karşılanabilmesi için endüstriyel üretimi yoğunluk kazanmış olan çiğ köfte, halk sağlığının korunması amacıyla çiğ et ilavesi olmadan üretilmektedir. Hammadde kalitesi, muhafaza koşulları, personel hijyeni ve ısıl işlem görmeden tüketilmesi gibi nedenler, çiğ köfteleri gıda hijyeni bakımından riskli hale getirmektedir. Bu çalışmada, 100 adet etsiz çiğ köfte örneği patojen Candida spp. varlığı yönünden analiz edildi. Etsiz çiğ köfte örneklerinin %10’unda Candida albicans, %2’sinde C. albicans ve C. krusei ile %2’sinde ise C.albicans, C. tropicalis ve C. krusei olmak üzere üç farklı tür ile kontaminasyon tespit edildi. Gıda örneklerinin mikrobiyolojik incelemesinde toplam maya ve küf sayısı ile birlikte patojen mayaların varlığına yönelik analizlerin de yapılması toplum sağlığı açısından yararlı olacağı sonucuna varılmıştır.
Kanatlı İntestinal Spiroketozis
Authors: ÇOKAL Yavuz , GÜNAYDIN Elçin
Published: May 2020

Kanatlı intestinal spiroketozis (KİS), ticari yumurtacı ve
broyler damızlık tavuklarda, Brachyspira cinsine
ait patojenik türlerin neden olduğu bir infeksiyondur. KİS, büyüme geriliğine,
yumurta verim kaybına, yem tüketiminde artışa, yumurta kabuğunun dışkı ile
kirlenmesine ve yumurta kalitesinin düşmesine neden olarak ekonomik kayıplar
oluşturur. Birçok ülkede kanatlılarda Brachyspira
spp. varlığı ortaya konmuştur. Ülkemizde, bilgimiz dâhilinde, KİS şüpheli ve/veya sağlıklı
kanatlılardan Brachyspira spp.
izolasyonu ile ilgili herhangi bir rapor yoktur. Bu derleme çalışması ile
özellikle ticari yumurtacı tavukların sorunu olan KİS hakkında bilgi verilmesi
amaçlanmıştır.
Sıcaklık Stresi ile İndüklenen Broilerde Farklı Oranlarda Uygulanan Bitkisel Eksraktların Bazı Kan Parametrelerine Etkisinin İncelenmesi
Authors: BAYRAKTAR Bülent , TEKCE Emre
Published: May 2020

Sıcaklık stresi, immunosupressif etkisi nedeniyle kanatlılarda büyüme ve
gelişme geriliği, metabolik problemlerden ölüme kadar varabilen sağlık
sorunlarına yol açan önemli bir stres etmenidir. Bu çalışma, sıcaklık
stresine maruz kalan kanatlılarda bitkisel ekstre kullanımına bağlı olarak
serumda fosfor düzeylerinin karşılaştırılmasının yanı sıra eş zamanlı
olacak şekilde içme sularına ilave edilen stresin
etkisini azaltılmasında antioksidan özelliklere sahip Eucalytus glabutus labii (ökaliptus), Tymus
vulgaris (kekik), Cymbopogon nardus (sitronella) ve Syzgium aromaticum
(karanfil) bitkilerinden oluşan karışımının (EOM) bazı kan
parametreleri (Fosfor, Lipaz Na, Cl, UBİC, TBIC, % SAT)  düzeyi üzerine olan etkisi araştırılmıştır.
Araştırmada her birinde 50 adet hayvan olacak
şekilde 8 gruba ayrılmıştır.  Gruplar kendi içerisinde
her bölmede 10 adet hayvan olacak şekilde 5 alt gruba dizayn edilmiştir. 22 oC gruplarda UIBC ve TIBC parametreleri
üzerine kontrol grubuna kıyasla EOM karışımı verilen gruplarda artış olurken en
fazla artışın 500 ml/1000 l gruplarda görülmüştür. 36 oC gruplarda
ise UIBC, TIBC ve Cl parametreleri üzerine kontrol grubuna kıyasla azalma
olduğu en fazla azalmanın da 500 ml/1000L gruplarda olduğu tespit edilmiştir
(p<0,05). Deney sonucunda gruplara ait incelendiğinde sıcaklık stresine maruz kalan brolierlerin içme suyuna ilave edilen EOM’un
klinik yönden serumda P, Lipaz Na, % SAT
düzeyleri  üzerinde önemli bir etkisinin
olmadığı tespit edilmiştir (p>0.05).