bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficiency of high-intensity therapy with rosuvastatin for secondary prevention of cardiovascular complications in patients with a very high risk
Authors: Kolmakova T. E. , Alekseeva I. A. , Tmoyan N. A. , Ezhov M. V.
Published: January 2022

According to the latest international and Russian guidelines for the treatment of dyslipidemias, statins are defined as the main group of drugs that significantly reduce the level of low-density lipoprotein cholesterol (LDL-C) effectively prevent atherosclerotic cardiovascular diseases (CVD) and complications and can slow down the progression of atherosclerosis. The principle “the lower LDL-C, the better” is especially relevant in categories of patients with very high and extreme cardiovascular risk, and therefore, in order to achieve target LDL-C values (≤1.4 is optimal ≤1.0) in this category of patients, high-intensity lipid-lowering therapy should be used. Rosuvastatin remains the most effective statin. Its use makes possible to achieve target lipid values at the starting dose of treatment, enhances adherence to treatment, and also reduces the frequency of side effects associated with the use of high doses of other statins. In addition, the proven ability of rosuvastatin to reduce the volume of atherosclerotic plaque, by reducing the level of pro-inflammatory cytokines and C-reactive protein, normalizing endothelial function, antiplatelet action, that is, rosuvastatin, in addition to its powerful lipid-lowering effect, has anti-inflammatory and anti-ischemic effects. Also, rosuvastatin can be successfully used in the presence of comorbidities, including chronic kidney disease and chronic heart failure. Taking into consideration the urgency of the fight against the COVID-19 pandemic (coronavirus Disease 2019), which covered 220 countries, due to the lack of effective etiotropic drugs, the possibility of using statins, including rosuvastatin, for the treatment of comorbid patients with COVID-19, was evaluated.
Saponins-uptake and Targeting Issues for Brain-specific Delivery for Enhanced
Cell Death Induction in Glioblastoma
Authors: Suresh P.K.
Published: January 2022

Saponins represent a category of diverse, natural glycoside molecules that belong to the triterpenoid or the steroid class. They vary in terms of their solubility and permeability characteristics and are classifiable based on the biopharmaceutics classification system. They have drug delivery potential as surfactants that can solubilize cholesterol in the plasma membrane of tumorigenic cells. Glioblastoma is an important malignancy that can aggressively afflict the brain of humans with a poor prognosis. Glioblastoma Stem Cells (GSCs), are an important subset of cancer cells and are major determinants for drug resistance and tumour relapse. These cells are quiescent and have been known to survive current therapeutic strategies. Certain saponins have shown potential to eliminate glioblastoma cells in a variety of model systems and hence provide a sound scientific basis for their development as a “stand-alone” drug or as part of a drug combination (from the existing arsenal of drugs) developed for the treatment of glioblastoma. However, due to their reactogenicity towards the immune system and hemolytic potential, selective delivery to the tumorigenic site is essential. Hence, nano-formulations (liposome/emulsion-based delivery systems/nano-structured lipid and calix[n]arenes-based carriers) and variants that are resistant to saponin may serve as delivery tools that can be functionalized to improve the selectivity. It is necessary to develop/validate/refine in vitro higher order models that replicate the features of the glioma microenvironment (BBB/BTB). Reproducible validation of the model as well as the drug/delivery system will help in the development of formulations that can augment cell death in this recalcitrant brain tumour.
Severe Lower Gastrointestinal Bleeding Due to Choriocarcinoma with
AVM to the Ileum: A Case Report
Authors: Hasanzadeh Malihe , Jahani Najmeh , Khoroushi Farzaneh , Sharifi Nourieh
Published: January 2022

Background:

Choriocarcinoma and other placental tumors are rare, and metastasis to the gastrointestinal, especially the small bowel, is extremely rare. Furthermore, about 5% of all metastasis belongs to the GI tract.

Case Presentation:

We reported an 18 -year-old patient with severe GI bleeding. Serum BHCG level was 57322 mIU/mL. CT angiography and Pelvic MRI suggested a metastatic arteriovenous malformation to the small bowel. In surgery, we detected the AVM from the right side of the uterus to the ileum, and pathological findings confirmed the choriocarcinoma with metastatic AVM to the ileum.

Conclusion:

Chemotherapy started after surgery, and the patient was asymptomatic on follow-up after 14 months. The results showed that GTN was a differential diagnosis when patients are referred with these signs and symptoms.

ConclusioN:

Findings from this study suggest a high prevalence of paradoxical VL suppression but not immune CD4 gain in the studied subjects following cART. Larger studies are needed to corroborate these findings.
Comparison of the use of shock index and modified early obstetric warning score in COVID-19 obstetric emergency patients as ICU care parameters
Authors: Wahyuni Sri , Chalid Siti Maisuri T , Pelupessy Nugraha Utama , Arifuddin Sharvianty , Idris Irfan , Usman Andi Nilawati
Published: January 2022

The physiological parameters included in the Modified Early Obstetric Warning Score (MEOWS) table have been selectively selected so that they cover all the standard observations in the NEWS table with the addition of several parameters that are specifically. The population in this study were all pregnant women who were in RSIA Siti Khadijah I Makassar and RSUP Dr. Wahidin Sudirohusodo Makassar. The results showed that there was no significant difference between the shock index and the incidence of shock (p=0.418). The difference in frequency between the shock index and the incidence of shock in the ICU was 1 patient who was pregnant. Based on shock index with high and low categories did not differ significantly (p=0.418). The data also shows that the frequency of pregnant women who are in shock is higher, namely 44 people (57.9%) compared to those who are not in shock, namely 32 people (42.1%). There was no significant difference between the shock index and the incidence of shock (p=0.112). The difference in frequency between the shock index and the incidence of shock in the ICU was 5 patients with pregnant women. Shock frequency based on the MEOWS index was not significantly different (p=0.112).
Development of problem-based learning model for corruption prevention in improving anti-corruption attitude in citizenship learning health certificate
Authors: Angelia Inge , Ananda Azwar , Montessori Maria
Published: January 2022

This study aims to develop a valid, practical, and effective Problem Based Learning Model for Preventing Corruption to improve students' anti-corruption attitudes in the Citizenship Education course at the Health College. The process of developing this model refers to the ADDIE development model. The results showed that the validity of the Problem Based Learning model for Preventing Corruption which was actualized in the form of model books, lecturer books, student books, and anti-corruption attitude instruments on the validity criteria was very high. The practicality of the Problem Based Learning model to prevent corruption is in the very effective category. The average anti-corruption attitude skills after the intervention in the experimental class in both health high schools showed an increase in anti-corruption attitudes compared to the control class with results of 88.65 and 86.81 with N-Gain 0.56 and 0.49. based on the Independent T-Test test obtained sig (2-tailed) 0.000 <0.05. Based on these results, the Problem Based Learning To Prevent Corruption model meets the valid, practical, and effective criteria to improve students' anti-corruption attitudes and is expected to be an alternative reference to improve the quality of civics learning, especially in anti-corruption and corruption education.
TELE HEALTH IN THE DIGITAL ERA DURING COVID -19 A CASE STUDY OF UTTARAKHAND
Authors: Malhotra Rupa K
Published: January 2022

Tele-health services area very old facility available, but it never became a forefront technology or option for patients. During Covid 19 lockdown, when all the hospitals OPD and Private Clinics were closed then there was certainly a need for a therapy that could be available, keeping the social distancing in mind. This study on Tele-health is both a primary and secondary data-based study. The first objective of the study is based on a survey of patients and service providers. The other two objectives are studied through secondary data. Options left for chronic patients were explored, their awareness and satisfaction regarding these options were studied if there is a surge in Tele-health services usage, then what strategies should organizations adopt for the continuous use of these services after covid was also studied. The study shows a surge in the usage of Tele-Health services and remote monitoring of patients. Approximately 80% of the patients have cancelled their personal visits to doctors, and patients' satisfaction rate is more than 70%. A survey on service providers was also carried out, and the satisfaction level of doctors in providing Tele-health services were more than 65%. The study reflects that Tele-health services can be a boon for a state like Uttarakhand, where health services are scarce and were treating patients in remote areas is challenging.
INTERSECTING BEHAVIOR THROUGH PATTERNS OF SUBCONSCIOUS
Authors: Patil Savita P
Published: January 2022

This paper tries to bring out and identify the patterns that influence human behavior and tries to understand the origin and factors affecting it to bring it to shape. It also brings out a generic viewpoint on how a subconscious mind functions, intellectual ability, and relationship with the conscious mind. It also sheds some light on how memories are created and how the conscious mind comes into play to utilize the orders of the subconscious mind in terms of actions, reactions and behavioral characteristics. In this manuscript, the intersecting behavior of the person through patterns of the subconscious is studied.
Breath sound analyses of infants with respiratory syncytial virus-induced acute bronchiolitis
Authors: Kuruma Kenta , Otomo Tomofumi , Sakama Takashi , Akiyama Kousuke , Takakura Hiromitsu , Toyama Daisuke , Hirai Kota , Furuya Hiroyuki , Kato Masahiko , Mochizuki Hiroyuki
Published: January 2022

Introduction: The reliability of breath sound analysis using an improved
method in infants has been reported. Objective: Breath sounds of infants
with respiratory syncytial virus (RSV)-induced acute bronchiolitis were
analyzed to evaluate their specificity and examine their relationship
with the severity. Subjects and methods: We evaluated the inspiratory
and expiratory breath sound parameters of 33 infants (median age=2
months old) diagnosed with RSV-induced acute bronchiolitis. The sound
powers of inspiration and expiration and the spectrum curve indices
(ratio of the third and fourth area to the total area under the curve
and ratio of the power and frequency at 50% and 75% of the highest
frequency were evaluated at the acute phase and recovery phase.
Furthermore, the relationship between the breath sound parameters and
the clinical severity of acute bronchiolitis was examined. Results:
Analyses of the breath sound spectrogram showed that the power of
expiration at the acute phase was large, and was the
expiration-to-inspiration sound power ratio in a mid-frequency range
(E/I MF), with values decreased in the recovery phase. Data of the
inspiratory sound spectrum curve showed the improvement of airway
stenosis during the recovery period. Furthermore, there were significant
relationships between the E/I MF and SpO2 and the severity score of
acute bronchiolitis. Conclusion: In RSV-induced acute bronchiolitis,
specificity of breath sounds was observed in the expiration sound and
the reversible airway stenosis was evaluated. Breath sound analyses are
expected to be useful for the diagnosis and clinical evaluation of the
severity of acute bronchiolitis.
Spontaneous bilateral intra-orbital hematoma: A particular form of complications of sickle cell disease in children.
Authors: Andriamiarintsoa Haritanjona , RAMANANDAFY Herveat , Randriantiana Koloina , Randrianarivelo Prosper Harinarivo , Andrianah Emmylou Prisca Gabrielle , Rajaonarison Lova Hasina Ny Ony Narindra , Rakotoson Joëlson Lovaniaina , Vololontiana Hanta Marie Danielle , Ahmad Ahmad
Published: January 2022

Spontaneous bilateral intra-orbital hematoma is a rare complication of
sickle cell disease in children. Imaging examinations are of paramount
importance in the diagnosis and condition the management in order to
avoid complications that can compromise the visual function prognosis.
Nasal transcriptome and epigenome analysis identifies the pathogenic features of aspirin-exacerbated respiratory disease
Authors: Ban Ga-Young , Kwon Eun-Kyung , Kang Tae-Wook , Oh Taeyun , Choo Oak-Sung , Ye Young-Min , Park Hae-Sim
Published: January 2022

Background: Dysregulation of the arachidonic acid metabolic pathway is
the most widely known pathomechanism of AERD. We performed integrative
analysis of transcriptomic and epigenomic profiling with network
analysis to determine the novel pathogenic features of AERD. Methods:
Ten patients with asthma including 5 patients with AERD and another 5
patients with aspirin tolerant asthma (ATA) were enrolled. Nasal
epithelial scraping was performed and nasal mucosa was used in omics
profiling. Peripheral eosinophil counts, sputum eosinophil counts, FeNO
levels, and pulmonary function test results were evaluated.
Differentially expressed genes (DEGs), differentially methylated probes
(DMPs) and differentially correlated genes (DCGs) between patients with
AERD and those with ATA were analyzed. Network analysis using Ingenuity
Pathway Analysis (IPA) was performed to determine the gene connection
network and signaling pathways. Results: In total, 1,736 DEGs and 1,401
DMPs were identified. Finally, 19 pairs for DCGs were selected. Among
DCGs, genes related to vesicle transport (e.g. STX2 and
RAB3B) and sphingolipid dysregulation (e.g. SMPD3) were
found to be hypo-methylated and up-regulated in patients with AERD. A
total number of 78 asthma-related DEGs were identified by the IPA
knowledge base. Using the canonical pathway analysis of IPA, signaling
pathways of T helper cell differentiation/activation and Fcε receptor I
were generated. Up-regulation of RORγt and down-regulation of
MHCII, TNFR, and TGF-β as well as up-regulation of
FCER1A and JAK and down-regulation of VAV and
cPLA2 were noted in patients with AERD. Conclusions: Distinct
pathogenic features were identified by using integrative multi-omics
data analysis in patients with AERD.
Surgical transcatheter valve implantation: the more pathways, the better.
Authors: Bruno Vito , Angelini Gianni
Published: January 2022

Transcatheter aortic valve implantation (TAVI) is rapidly spreading
across the world with the endorsement of the cardiological community(1)
and the supporting results of randomised controlled trials (2,3).
However, TAVI-related complication like aortic dissection, aortic
valvular rupture, or left ventricle perforation are still potentially
catastrophic (4).
Rancang Bangun Sistem Hidung Elektronik Berbasis Sensor Gas MQ untuk Mengevaluasi Kualitas Madu
Authors:   Universitas Riau, Shiddiq Minarni , Fadlillah Annisa , Ningsih Sinta Afria , Husein Ikhsan Raahaman
Published: January 2022

Honeys come in many varieties based on quality attributes and region origin. Electronic nose systems have been adopted and used to classify honey types based on physicochemical parameters. This study was aimed to build a low cost electronic nose (e-nose) based on metal oxide semiconductor (MOS) gas sensors, and then used to evaluate the qualities of two types of honeys and one non honey based on sugar contents and pH values. Six gas sensors of MQ modules namely MQ2, MQ3, MQ4, MQ5, MQ6, MQ9, and an Arduino microcontroller were used in this system. Software of Arduino IDE, PLX-DAQ, and Python were applied to record output voltages of each sensor, saved in Excel format, and to calculate trapezoid areas respectively. Honey samples were named as A, B, and C which were. a national brand honey, a local forest honey, and date syrup respectively. The results show higher output voltages for MQ 3, MQ 4, and MQ 6 sensors. The six sensors are able to differentiate between the two honey types and non honey. Sample A has the highest trapezoid area while sample C has the lowest area. This could be caused by higher pH value of sample C.
Penentuan Titik Pengamatan Optimal Terhadap Kualitas Udara pada Gas Keluaran Diffuser berbasis Internet of Things
Authors:   Institut Teknologi Telkom Purwokerto, Hikmah Irmayatul , Ramadhani Afifah Dwi , Syifa Fikra Titan
Published: January 2022

Indoor air quality needs attention, especially during the COVID-19 pandemic because the majority of activities are carried out indoors. The air in the room must be protected from the threat of harmful virus and bacterial contaminants. One such innovation is placing diffuser in the room. Diffuser is a device that converts liquid into gas particles in the air. To reduce harmful virus contamination, a natural antiseptic liquid is filled into the diffuser, one of which is papermint essential oil, which can provide freshness in the room. Air quality is monitored with internet of things (IoT) technology so that users can easily control air quality with just a PC/gadget. The gas output from the diffuser is detected by a gas sensor that is connected to the wemos board so that the data can be connected to the internet cloud. To obtain optimal air quality data, the placement of gas sensors in the area around the diffuser as a point of observation needs to be considered because the distribution of gas in the air is influenced by the vertical wind speed in the room, this can affect the quality of the data generated. This study aims to determine the optimal observation point on an IoT-based diffuser so that the resulting air quality data is more accurate. In this study the gas sensor was placed at a distance of 15 and 25 cm from the diffuser. The direction of the gas sensor placement was adjusted according to the angle of the full circle ranging from 0°, 45°, 90°, 135°, 180°, 225°, 270°, 315°, and 0°. The distribution of gas is influenced by the vertical wind speed in the room causing the air quality data at a vertical angle to always have the same pattern. From the results obtained, the optimal observation point as a reference for the position of the gas sensor to the diffuser is at an angle between 135°-180° as well as at an angle between 315° -0°.
Equity provision equal-pay for work of equal-value implementation within South African State-Owned Enterprise (SOE)
Authors:   University of Johannesburg, APK Campus, South Africa, Langa Lesiba , Bronkhorst Seugnet ,   University of Johannesburg, APK Campus, South Africa
Published: January 2022

Purpose of the research: The purpose of the study is to determine how a state-owned enterprise in South Africa deploys equal pay for work of equal value. The research setting and environment where the investigation takes place are located in a state-owned enterprise (SOE) called ZYD. Research methodology: An inductive research approach is used with qualitative research for primary data and for secondary numeric data. The research includes a population sample of eight participants who are involved in the primary research data collection. In addition, a company finance report is analysed for the secondary data collection. Equally, some qualitative primary research data are analysed quantitatively in order to make sense of the data (Saunders, Lewis & Thornhill, 2012:165). Results/findings:The study confirms that implementing equal pay has a financial implication attached to it, insignificant as it is. Uncoordinated confirmations for promoting equal pay exist. Lack of a comprehensive approach to equal pay encompasses the majority concerns. The study shows how important it is for the organisation to have all essential pillars in place and in sync with one another, which lagged in this case. With the essential pillars in place and in sync, a robust pay equity system/model, which is supported by policy, will be leveraged and initiated as a business imperative, promoting open communication and empowerment about equal pay (Bradshaw, et al., 2017:3). Vignettes have been constructed and highlighted in order to bring alive the participants’ voices within the researcher’s interpretations of meaning. Practical implications and Conclusions: South African researchers and researchers across the globe have shown little interest to explore the racial pay discrimination situation; they have constantly researched gender-based pay inequity instead. This should be reason enough to have future research studies focusing on pay equity irrespective of race, gender or disability.
POSSIBILITIES OF EARLY DIAGNOSIS OF PRIMARY CILIARY DYSKINESIA
Authors:   People’s Friendship University of Russia, Moscow, Russia, Frolov P.A. ,   Morozov Children’s City Clinical Hospital, Moscow, Russia, Kolganova N.I. ,   People’s Friendship University of Russia, Moscow, Russia, Ovsyannikov D.Yu. ,   People’s Friendship University of Russia, Moscow, Russia,   Morozov Children’s City Clinical Hospital, Moscow, Russia, Ozerskaya I.V. ,   I.M. Sechenov First Moscow State Medical University, Moscow, Russia, Tsverava A.G. ,   Morozov Children’s City Clinical Hospital, Moscow, Russia, Topilin O.G. ,   Morozov Children’s City Clinical Hospital, Moscow, Russia, Airapetyan M.I. ,   Morozov Children’s City Clinical Hospital, Moscow, Russia,   I.M. Sechenov First Moscow State Medical University, Moscow, Russia, Strelnikova V.A. ,   People’s Friendship University of Russia, Moscow, Russia, Akhmina N.I. ,   Russian Medical Academy for Continuous Professional Education, Moscow, Russia, Buldakov I.A. ,   Pirogov Russian National Research Medical University, Moscow, Russia, Pushko L.V. ,   People’s Friendship University of Russia, Moscow, Russia, Gorev V.V. ,   Morozov Children’s City Clinical Hospital, Moscow, Russia,   Russian Medical Academy for Continuous Professional Education, Moscow, Russia
Published: January 2022

Despite the manifestations of primary ciliary dyskinesia (PCD) in the neonatal period or in the first year of life, the diagnosis of this rare disease is usually established at the age of 4–7 years. The aim of the study was to search for reserves for early diagnosis of PCD. Materials and methods of research: 17 patients were observed with PCD, confirmed on the basis of the PICADAR scale, highspeed light video microscopy (all patients) and transmission electron microscopy (in 3 patients) of the mucous biopsy of the respiratory membrane using a genetic study (in one patient). Results: all patients were born full-term; neonatal respiratory distress syndrome (RDS) was observed in 71% of patients; the median duration of mechanical ventilation/oxygen therapy was 14 [7; 21] days; lateralization abnormalities were found in 35% of patients; all patients had persistent nasal congestion and/or rhinorrhea, 94% had chronic or recurrent sinusitis, otitis, recurrent pneumonia, chest x-ray and computed tomography (CT) scans in 71% had atelectasis with constant localization in the middle lobe, 12 of 15 patients, traced in the follow-up, – bronchiectasis (BE), also mainly in the middle lobe (in 9 patients). The average age at diagnosis was 5 [1.75; 7] years, patients with an established diagnosis over the age of 3 years were more often diagnosed with BE. The median of PICADAR scores was 7 [6; 8] points. Conclusions: to establish early diagnosis of PCD, it is important to consider neonatal RDS, lateralization of organs, difficulty in nasal breathing, starting from the first half of life.
NEONATAL SEPSIS: MODERN DIAGNOSTIC CAPABILITIES
Authors:   Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russia, Dmitriev A.V. , Zaplatnikov A.L. ,   Russian Medical Academy for Continuous Professional Education, Moscow, Russia
Published: January 2022

The literature review presents current knowledge of risk factors, etiology, the main links of immunopathogenesis, clinical manifestations and laboratory guidelines for neonatal sepsis (NS). It is emphasized that NS remains a serious health problem. At the same time, it is specified that the incidence rates of early HS in children born prematurely are 60 times higher than in fullterm children, and mortality is 16.6 times higher. It was also noted that the frequency of late NS with an increase in body weight at birth from 500 g to 2500 g decreases from 51.2% to 2.2%. The main predisposing factors of increased morbidity and mortality from NS in premature infants are presented. The modern possibilities of laboratory diagnostics of the disease are analyzed in detail. The main characteristics (sensitivity, specificity, diagnostic significance) of clinical and laboratory markers of NS are given. It is emphasized that the diagnosis of NS remains clinical, which does not exclude the important task of finding highly sensitive and highly specific markers for more accurate and early screening of this disease, which will allow timely initiation of adequate therapy and ultimately determine a decrease in mortality and long-term consequences for health and quality of life.
STARD AND TRIPOD: RECOMMENDATIONS FOR THE PROVISION OF DIAGNOSTIC AND PROGNOSTIC RESEARCH RESULTS. PRACTICAL ADVICE FOR SUBMITTING ARTICLES TO JOURNALS
Authors:   Scientific and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Department of Healthcare, Moscow, Russia, Schepkina E.V. ,   "Statistics for Medicine" Department with the "Techdepartment," LLC, Khimki, Moscow Oblast, Russia, Epifanova S.V. ,   Scientific and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Department of Healthcare, Moscow, Russia,   Central Clinical Hospital with Polyclinic of the Office of the President of the Russian Federation, Moscow, Russia, Kuznetsov A.I. ,   Moscow Aviation Institute (National Research University), Moscow, Russia
Published: January 2022

The physician in his daily clinical practice must constantly make decisions. Moreover, the accuracy of diagnostic methods of research and scales for predicting the risk of developing a particular disease determines the accuracy of the diagnosis made by the doctor or the decision on the method of treatment. The number of publications devoted to predictive models is growing rapidly in the medical literature, which determines the need to improve the quality of publications describing the development and validation of predictive and diagnostic models for various diseases. The recommendations set out in STARD and TRIPOD help to write a quality publication. This article provides comments on the updated STARD and TRIPOD manuals. For all points of the manual, a description is given of what is required from authors to compile complete and informative reports (with examples). These recommendations apply not only to the design of articles, but also to dissertations, reports on grants and other works devoted to medical research.
COMPLETE BLOOD COUNT: REFERENCE INTERVALS FOR FULL-TERM AND LATE PREMATURE INFANTS IN THE FIRST DAY OF LIFE (PART I)
Authors:   Kaluga Oblast Regional Clinical Hospital, Kaluga, Russia, Karpova A.L. ,   Yaroslavl State Medical University, Yaroslavl, Russia
Published: January 2022

Knowledge of the reference intervals for complete blood count (CBC) indicators in newborns, depending on gestational age (GA), will allow the doctor to obtain important information about a specific disease, build a treatment plan and consider introduction of CBC as a screening technology in conditions of early discharge from a maternity hospital. Objective of the study: to establish and compare reference intervals of CBC indicators in full-term and late premature infants (LPI) who do not need intensive care and are in the physiological department on the first day of life, in order to use them as standard values in clinical practice. Materials and methods of research: multicenter prospective cohort study, conducted from 2019 to 2020. The study involved 4376 term and late preterm infants. Inclusion criteria: 1) APGAR score at the first minute of 7 points or more; 2) age 18–24 h of life; 3) absence of diseases in newborns by the end of the first day of life; 4) GA at birth from 35 0/7 to 41 6/7 weeks. Infants with any diseases or conditions that could affect the CBC indicators, with congenital malformations that significantly affect the child's condition, chromosomal abnormalities and genetic syndromes, as well as when parents refused to participate in the study were excluded. Two comparison groups: group 1 (n=3225) – full-term, group 2 (n=109) – LPI. Results: reference intervals for hemoglobin, hematocrit, erythrocytes, reticulocytes, platelets, leukocytes, RDW-CV, MPV are presented in the text of the article in tables and nomograms depending on GA. When comparing the CBC indicators in term and LPI, statistically significant differences in the number of leukocytes were found 22.8 [19.1–27.2]×109/L versus 18.0 [14.7–21.5]×109/L (p<0.001); erythrocytes 5.6 [5.1–6.1]×1012/L versus 5.3 [4.9–5.9]×1012/L (p=0.001); platelets 259.0 [219.0–301.0]×109/L versus 236.0 [183.5–285.0]×109/L (p<0.001), as well as in terms of distribution of erythrocytes by volume (RDW-CV) – 17.2 [16.2–18.6]% versus 16.7 [16.2–17.9]% (p=0.043) and the average platelet volume in femtoliters (fl) – 9.6 [ 9.0–10.2] fl versus 9.2 [8.8–10.2] fl (p=0.006), respectively. Conclusions: the number of leukocytes, erythrocytes, platelets, RDW-CV and MPV in the LPI blood is lower in comparison with full-term infants at the end of the first day of life. The reference intervals for CBC indicators presented in the study can be used in clinical practice.
Matriks Circulant Kompleks Bentuk Khusus 3 × 3 Berpangkat Bilangan Bulat
Authors: Mamula Dewinta , Achmad Novianita , Resmawan Resmawan
Published: January 2022

This article identifies the general form of matrix power and trace of an integer power of Special Form of the 3 × 3 Complex Circulant matrix. The research begins to determine the general form of an integer power of Special Form of the 3 × 3 Complex Circulant matrix, followed by determining the general form trace of an integer power of Special Form of the 3 × 3 Complex Circulant matrix. The proof is done by using mathematical induction. The final result of this article is to obtain the general form of the matrix A^n and tr(A^n) for n integers in special form of the 3 × 3 complex Circulant matrix.
The canonical FGF-FGFR signaling system at the molecular level
Authors: Szybowska Patrycja , Haugsten Ellen Margrethe , Wiedlocha Antoni
Published: January 2022

Extracellular signaling molecules, among them the fibroblast growth factors (FGFs), enable cells to communicate with neighboring cells. Such signaling molecules that receive and transmit a signal require specific tyrosine kinase receptors located at the cell surface (fibroblast growth factor receptors, FGFRs). The binding of a signaling molecule to its specific receptor results in receptor dimerization and conformational changes in the cytoplasmic part of the receptor. The conformational changes lead to trans-autophosphorylation of the tyrosine kinase domains of the receptors and subsequently to induction of several downstream signaling pathways and expression of appropriate genes. The signaling pathways activated by FGFs control and coordinate cell behaviors such as cell division, migration, differentiation, and cell death. FGFs and their transmembrane receptors are widely distributed in different tissues and participate in fundamental processes during embryonic, fetal, and adult human life. The human FGF/FGFR family comprises 22 ligands and 4 high affinity receptors. In addition, FGFs bind to low affinity receptors, heparan sulfate proteoglycans at the cell surface. The availability of appropriate ligand/receptor pair, combined with the co-receptor, initiates signaling. Inappropriate FGF/FGFR signaling can cause skeletal disorders, primarily dwarfism, craniofacial malformation syndromes, mood disorders, metabolic disorders, and Kallman syndrome. In addition, aberrations in FGF/FGFR signaling have already been reported in several types of malignant diseases. Knowledge about the molecular mechanisms of FGF/FGFR activation and signaling is necessary to understand the basis of these diseases.
Comparative Toxicity of Lunar, Martian Dust Simulants, and Urban Dust in Human Skin Fibroblast Cells
Authors: Wise James T.F. , Xie Hong , Wise John Pierce , Mason Michael , Jeevarajan Antony , Wallace William , Wise John Pierce
Published: January 2022

The National Aeronautics and Space Administration (NASA) has plans to further their manned space exploration to Mars and possibly beyond. The potential toxicity of lunar and Martian dusts to astronauts is a big concern. Primary routes of exposure for astronauts are dermal contact, ocular contact, and inhalation. In this study, we focused on dermal contact exposure using human skin cells to investigate the cytotoxic and genotoxic effects of two fractions of lunar dust simulant (JSC-1A-vf, JSC-1A-f) and a Mars dust simulant (Mars-1A), and compared them to urban dust (urban particulate matter), as urban dust toxicity is better understood and thus, provides a good comparison. Our data show the three simulants and urban dust are cytotoxic to human skin cells. The JSC-1A-vf lunar dust simulant is more cytotoxic than the JSC-1A-f and urban dust. Urban dust cytotoxicity is similar to Mars dust simulant after 120 h exposure. All three dust simulants and urban dust show similar low genotoxicity effects. Our data suggest extraterrestrial dust can damage skin cells and may have the potential to be harmful to humans.
Mapping by VESGEN of Wing Vein Phenotype in Drosophila for Quantifying Adaptations to Space Environments
Authors: Parsons-Wingerter Patricia , Hosamani Ravikumar , Vickerman Mary B. , Bhattacharya Sharmila
Published: January 2022

Vascular patterning is a key, genetically responsive phylogenetic classifier of tissues in major organisms flown in space, such as the wings of Drosophila melanogaster (the fruit fly), mouse retina, and leaves of Arabidopsis thaliana. Phenotypes of increasingly abnormal ectopic wing venation in the highly stereotyped Drosophila wing generated by overexpressing the H-C2 construct of Notch antagonist Hairless (Johannes and Preiss, 2002) were mapped and quantified by NASA’s VESsel GENeration Analysis (VESGEN) software. By several confirming vascular parameters, the eight stereotyped wing veins remained quite constant in wild type compared to Class 5 H-C2, the most perturbed category of the H-C2 overexpression phenotypes. However, ectopic veins increased in number from 1 in the wild type, to 18 in Class 5 H-C2. We therefore demonstrate the feasibility of using VESGEN to quantify microscopic images of altered wing venation in Drosophila melanogaster. We further determined that several of the signal transduction pathways affecting wing vein patterning were altered by spaceflight, according to gene expression differences observed in our transcriptomic data from a previous shuttle flight experiment. Future studies will help characterize the extent to which these gene expression changes can cause even subtle developmental changes using model organisms, such as Drosophila. Therefore, we propose that the sensitive analyses provided by VESGEN software will not only serve as a useful tool to map the genetics of wing vein patterning for terrestrial applications, but also for future phenotypic studies with Drosophila for spaceflight missions.
ASPEK RELIGIUS NOVEL SEBELAS PATRIOT KARYA ANDREA HIRATA
Authors: Marwanto Marwanto
Published: January 2022

This study aims to describe the religious aspect and examine the problem of how the religious aspect of Andrea Hirata's Eleven Patriot novel and its implementation as literary material in high school. Qualitative descriptive is used to describe religious aspects through religious beliefs, practices, experiences, knowledge, and consequences. This novel tells about patriotism and religious routine activities of Ikal. He is described as a child who is obedient to his parents, and even becomes an inspiration in determining his life and goals.
ANASIR BABAD DESA SIRKANDI DALAM PERSFEKTIF STRUKTURALISME LEVI-STRAUSS
Authors: Kurnianto Ery Agus
Published: January 2022

The Babad Desa Sirkandi is one of the folklore that lives and develops in the social community of the Banjarnegara community. Babad Desa Sirkandi is an interesting topic of this study  because as far as the author's knowledge there has been no research that examines the chronicle (Babad). Babad Desa Sirkandi is a baboon of folklore in the village of Sirkandi. To analyze the chronicle, researcher used descriptive methods. The approach used to analyze the Babad Sirkandi is an objective approach. This approach was carried out to analyze the intrinsic elements that built the Babad Desa Sirkandi story. the object this research is folklore from Banjarnegara in the form of babad, namely Babad Desa Sirkandi. Based on the  research result, it can be concluded that (1) Babad Desa Sirkandi consists of eight episodes.; (2) the babad is formed by 56 mythems: (3) the identified myths have five binary opposition structures; (4) Babad Desa Sirkandi has three historical life structures: (5) Babad Desa Sirkandi has three layers of social strata, namely the upper layer, middle layer, and lower layer; (6) Karanggintung Village community believes  in the concept of Manunggaling Kawula Gusti: (7) there are three symbolic messages.
NILAI-NILAI MULTIKULTUR DALAM ANTOLOGI CERITA RAKYAT SINGKAWANG
Authors: Febrianti Binar Kurniasari
Published: January 2022

This paper aims to describe multicultural values in Singkawang folklore. Singkawang folklore anthology, which reveal past socio-cultural life inherited from generation to another generation, underlies the paper. Folklore tells things related to natural phenomena, the social life of the community, and customs of origin. This paper is descriptive analysis with a literature study method and uses the theory of sociology of literature. The data source of this paper is Singkawang folklore text by applying the technique of reading and writing. The results showed that Singkawang folklore contained multicultural values, including tolerance values, equality values, religious values, cultural values, solidarity values, trade values, family values,  simplicity, unyielding values, values of appreciation, and values of keeping promises. These multicultural values are still relevant and applied today. Thus, Singkawang folklore shows cultural diversity that is important as a socio-cultural reality.
SIKAP BERBAHASA SISWA SEKOLAH DASAR DI KOTA SINGKAWANG: KAJIAN SOSIOLINGUISTIK
Authors: Herawati Ida
Published: January 2022

The phenomenon of using language in educational institutions, especially elementary schools, attracted the attention of many sides because it was pointed out that several educational institutions use foreign or regional languages during learning and teaching process. The problem in this study is how the use of language and language attitudes of elementary school students in Singkawang. The aim of this study is to describe the use of language and language attitudes of elementary school students in Singkawang. The method used is descriptive with quantitative and qualitative approaches. Collecting data conducted by observation, interviews, and distributing questionnaires to several primary schools in Singkawang. The number of questionnaires distributed was 50 copies with details: respondent, the use of language, language attitudes, language activities, and attitudes towards neighboring countries. The analysis focus was related to language use and language attitudes. The analysis result showed that the use of Indonesian was more dominant than other languages, ranging between 28%-74%, local languages 24%-28%, and foreign languages 2%-28%. Elementary school students' language attitudes in Singkawang described the use of Indonesian 82.7% -96.2%, local languages 1.9% -13%, and foreign languages 1.9%-40.4%.
LANSKAP LINGUISTIK PADA RUMAH SAKIT DI KABUPATEN KULON PROGO
Authors: Riani NFN
Published: January 2022

Penelitian ini membahas pemakaian bahasa di lingkungan rumah sakit dalam perspektif linguistik lanskap. Papan nama dan petunjuk di rumah sakit memiliki peranan penting dalam memberikan informasi kepada para praktisi kesehatan dan terutama pasien yang berobat. Oleh sebab itu, penelitian ini bertujuan untuk mendeskripsikan pengunaan bahasa Indonesia pada ruang publik di lingkungan rumah sakit dari aspek situasi kebahasaan, bentuk bahasa, kesalahan dalam pemakaian bahasa, dan fungsinya. Penelitian ini merupakan penelitian deskriptif kualitatif. Data penelitian ini adalah teks bahasa Indonesia atau Inggris pada rumah sakit di Kabupaten Kulon Progo, DIY. Metode penelitian meliputi mengobservasi, mendokumentasikan data dengan cara difoto, mengklasifiasikan data, menganalisis data. Hasil penelitian menunjukkan bahwa   berdasarkan aspek situasi, penggunaan bahasa di rumas sakit terdiri atas (1) monolingual (bahasa Indonesia atau bahasa Inggris) dan (2) bilingual (bahasa Indonesia dan bahasa Inggris). Berdasarkan bentuknya terdapat lima jenis, yaitu (1) kata, (2) frase, (3) kalimat, dan (4) wacana. Berdasarkan penggunaan bahasa diketahui terdapat kesalahan pada aspek (1) ejaan, (2) diksi, (3) kalimat, dan (4) wacana. Berdasarkan fungsinya ada tiga jenis, yaitu (1) informasi,  (2) imbauan, (3) petunjuk, dan (4) ungkapan fatis.
Partially substitution of wheat flour by coconut residues in bakery products and
their physical and sensorial properties
Authors: Eadmusik S. , Phungamngoen C. , Panphut W. , Budsabun T.
Published: January 2022

The food process generates certain amounts of agricultural wastes and by-products. These
materials are considerably non-valuable and normally sold for livestock feed. Coconut
residue is one of the by-products obtained from coconut milk extraction. Thus, this study
was aimed to valorise coconut residue powder (CRP) by partial substitution of wheat flour
in deep fried donut and butter cookies and to investigate how different CRP substitution
levels affect the physical and sensorial qualities of these bakery products. CRP was
prepared by drying coconut residues at 55oC for 9 hrs, size reducing with a blender at
24,000 rpm for 40 s and sieving through a 35-mesh sifter. Protein, ash, fat and
carbohydrate contents of coconut flour were 3.82, 0.72, 39.83 and 55.64% on dry basis,
respectively. After the utilization of CRP by partial substitution wheat flour in deep fried
donut (5%, 10% and 15%) and butter cookies (10%, 15% and 20%), it was found that
CRP can substitute wheat flour in the donut and cookies productions by 10% and 15%,
respectively. Donuts with higher substitution levels had lower specific volume but higher
L*, a*, ∆E*-values, hardness and chewiness. For butter cookies, an increase in CRP
substitution level led to higher hardness but it did not significantly affect the fracturability
and the ∆E*-value. An increase in CRP substitution level also reduced the overall-liking
score. The overall-liking scores of fried donuts with 10% CRP substitution level and
butter cookies with 15% CRP substitution level were 6.43 (slightly like) and 7.00
(moderately like), respectively. This study showed the value-adding of agricultural waste
such as coconut residue by its application in food production.
Sistem Traksi Kereta Rel Listrik Dengan Teknologi VVVF
Authors: Taufik Hidayat
Published: January 2022

The electrical system of electric railcar with the variable voltage variable frequency (VVVE) technology has been equipped with different devices functioning to change the DC-link voltage from the overhead line in undesired conditions. It also transmits energy powered by the motor due to a braking process not able to be transmitted back to the overhead line, and keeps the DC-link voltage stable during the braking process. The inverter functions to change the DC-link voltage into a source of AC 3 phase whose voltage and frequency can be regulated. The voltage and frequency variables produced are used to power four induction motors. The rotation speed of the motor can be set as desired by regulating the voltage and frequency of the AC source. Another function is to transmit back the force generated by the motor during the braking to the overhead line.
Perancangan Alat Bantu Proses Penyortiran Alumina Ball Pada Mesin Ball Mill Departemen Body Preparation
Authors: Cucu Wahyudin  , Ikhsan Maulana
Published: January 2022

XYZ adalah perusahaan yang bergerak dalam bidang manufaktur yangmemproduksi keramik.

Penelitian ini dilakukan di departemen body preparation, tempat terjadinya proses penyortiran alumina bal

Alumina ball adalah sebuah batuan yang digunakan untuk proses penggilingan bahan baku utama di mesin ball mill.

Hasil pengamatan di lantai produksi, menunjukan bahwa kegiatan penyortiran alumina ball masih dilakukan secara manual dan merupakan kegiatan yang rutin. Proses penyortiran alumina ball yang umumnya berlangsung lamban menyebabkan berbagai keluhan operator, seperti timbulnya rasa pegal-pegal dan nyeri atau sakit pada bagian punggung, kaki, leher, dan kaki. Kegiatan penyortiran secara manual menghasilkan 2 ton alumina ball tersortir per hari, hanya 26 dari yang seharusnya disortir, dengan melibatkan empat orang operator.

Oleh karenanya, perbaikan sistem kerja perlu segera dilakukan, diantaranya dengan merancang alat saringan yang dapat mempermudah, mempercepat dan memperbaiki posisi kerja operator sehingga selama bekerja memiliki rasa rasa nyaman dengan hasil sortiran yang lebih banyak.

Proses perancangan alat saringan pada penelitian ini menggunakan metode Ouality Function Deplovment (OFD) yang dikombinasikan dengan pendekatan engineering design yang banyak digunakan pada proses perancangan mesin.
Pengaruh Waktu Penahanan Proses Pengerasan Permukaan Cyaniding Terhadap Laju Difusi Nitrogen Terhadap Struktur Dan Sifat Mekanik Baja Perkakas Assab Xw-42
Authors: Abrianto Akuan
Published: January 2022

Salah satu metoda pengerasan permukaan dengan jalan merubah komposisi kimia yaitu dengan proses Cyaniding. Atom N (Nitrogen) diperoleh dari hasil reaksi garam KFe(CN), dengan oksigen/udara dengan aktivator Na2CO3. Atom N akan berdifusi masuk kedalam permukaan sehingga pada permukaan akan diperoleh lapisan white keras Fe4N dan Fe2N yang sifatnya keras. Proses cyaniding ini dilakukan dengan memyvariasikan waktu yaitu 3, 9 dan 21 jam dengan temperatur 580oC. Dari hasil penelitian ini lapisan yang terbentuk pada proses 3 jam yaitu dengan rata rata 40,870Âµm , untuk proses 9 jam lapisan yang terbentuk rata-rata 58Âµm dan proses 21 jam lapisan yang terbentuk rata-rata 61,109Âµm. Sedangkan kekerasan yang dihasilkan akibat terbentuknya lapisan nitrida besi: Fe4N adalah untuk proses 3 jam 771,61 Hv, proses 9 jam 763,13Hv dan 21 jam 760,27 Hv.