bluuebunny/crossref_metadata_2025 huggingface dataset:
Outcome After Crossing Femoropopliteal Chronic Total Occlusions Based on Optical Coherence Tomography Guidance
Authors: Schaefers Johannes F. , Schwindt Arne G. , Maritati Gabriele , Torsello Giovanni , Pannucio Giuseppe
Published: October 2017

Aims:

The crossing of chronic total occlusions (CTOs) is the key step for an endovascular treatment. The Ocelot system is a novel device that combines a steerable drilling tip with optical coherence tomography (OCT) technology. It provides intraluminal imaging to help the crossing of CTOs in the femoropopliteal segment. Aim of the study was to determine early and midterm results after recanalization with this device.

Methods and Results:

During a period of 16 months, 84 CTOs were treated using the Ocelot system and prospectively registered. The primary end points were technical success and the primary and secondary patency of the lesion. Risk factors associated with early and midterm results were also analyzed. In all, 58 (69.0%) lesions were treated for intermittent claudication, 26 (31.0%) for critical limb ischemia, 34 (40.5%) were classified as Trans-Atlantic Inter-Society Consensus II D lesions, and 22 (26.2%) showed severe calcifications. The technical success rate was 72.6%. During 36 months of follow-up (mean 25.9), there were 10 reinterventions. The primary and secondary patency at 36 months were 54.2% and 68.1%, respectively.

Conclusions:

In our experience, the Ocelot system would appear to be a safe and effective tool for increasing the applicability of endovascular techniques. However, the midterm results did not show drastic improvement.
IL-17 and VEGF are increased and correlated to systemic inflammation, immune suppression, and malnutrition in patients with breast cancer
Authors: Tachibana Kazunoshin , Shibata Masahiko , Gonda Kenji , Matsumoto Yoshiko , Nakajima Takahiro , Abe Noriko , Ohtake Tohru , Ohto Hitoshi , Kono Koji , Takenoshita Seiichi
Published: October 2017

Relationships between inflammation and innate immunity in cancer are widely accepted today; however, the precise cell mechanisms mediating these relationships have not yet been elucidated. Interleukin (IL)-17 is a proinflammatory cytokine that has been reported to induce inflammation in patients with autoimmune diseases. Myeloid-derived suppressor cells (MDSC) may contribute to the negative regulation of immune responses during cancer and inflammation. Vascular endothelial growth factor (VEGF) is reported to have multiple biological actions including increasing vascular permeability, neovascularization, and possible inhibition of immune function in malignant diseases. This study investigated the status of systemic inflammation and immune suppression associated with IL-17 and VEGF in patients with breast cancer. IL-17 production and the serum levels of VEGF were also increased in advanced stages of the disease. The production of IL-12, which induces Th1 cells, and the stimulation index (SI), which is a marker of cell-mediated immune function, were both shown to decrease along with disease advancement. Also, the production of IL-17 and the VEGF levels were both positively correlated with the levels of MDSC, the neutrophil-to-lymphocyte ratio (NLR), and C-reactive protein (CRP), and were inversely correlated with IL-12 production and the SI. Nutritional markers, including prealbumin (PA), transferrin (TF), and retinol-binding protein (RBP), were also shown to be significantly lower in patients with high production of IL-17 or high levels of VEGF. These data clearly showed that IL-17 and VEGF, whose levels correlated with each other and with those of MDSC, were significantly associated with disease advancement, systemic inflammation, suppression of cell-mediated immunity including Th1 induction, and malnutrition.
The pharmaceutical market and drug development prognosis in Japan: Current and future perspectives according to pharmacological classes
Authors: Shibata Shoyo , Suzuki Takeshi
Published: October 2017

Japan is now the second largest pharmaceutical market in the world. As a unique population, it provides many opportunities for pharmaceutical companies to develop their businesses. However, the market is strictly regulated by the government, and drug prices are determined according to the rules in Japan. Nevertheless, no detailed empirical analyses have been conducted to clarify what opportunities may exist for pharmaceutical companies in the future. In the present article, we reviewed the pros and cons of the Japanese pharmaceutical market including related regulations, discussed our analyses of economic and regulatory science, and provided future perspectives on drug development and the pharmaceutical market in Japan. Specifically, we first clarified the Japanese pharmaceutical market profile using the publically available market database. Second, we reviewed the Japanese pharmaceutical pricing system, and found inconsistencies between the “pricing premium for the promotion of new drug development and the elimination/resolution of off-label use” and “repricing for market expansion” based on our literature review. Finally, we provided future perspectives on the pharmaceutical markets in Japan, as well as the direction of the research and development of new drugs.
The correlation between gain of chromosome 8q and survival in patients with clear and papillary renal cell carcinoma
Authors: Mehrazin Reza , Dulaimi Essel , Uzzo Robert G. , Devarjan Karthik , Pei Jianming , Smaldone Marc C. , Kutikov Alexander , Testa Joseph R. , Al-Saleem Tahseen
Published: October 2017

Background:

The proto-oncogene c-MYC, located on chromosome 8q, can be upregulated through gain of 8q, causing alteration in biology of renal cell carcinoma (RCC). The aim of this study was to evaluate the prevalence of c-MYC through chromosome 8q gain and to correlate findings with cancer-specific mortality (CSM), and overall survival (OS).

Methods:

Cytogenetic analysis by conventional or Chromosomal Genomic Microarray Analysis (CMA) was performed on 414 renal tumors. Nonclear and nonpapillary RCC were excluded. Impact of gain in chromosome 8q status on CSM, OS, and its correlation with clinicopathological variables were evaluated. CSM and OS were assessed using log-rank test and the Cox proportional hazards model.

Results:

A total of 297 RCC tumors with cytogenetic analysis were included. Gain of 8q was detected in 18 (6.1%) tumors (9 clear cell and 9 papillary RCC), using conventional method ( n = 11) or CMA ( n = 7). Gain of 8q was associated with higher T stage ( p < 0.001), grade ( p < 0.001), nodal involvement ( p = 0.005), and distant metastasis ( p < 0.001). No association between gain of 8q and age ( p = 0.23), sex ( p = 0.46), and Charlson comorbidity index (CCI, p = 0.59) were seen. Gain of 8q was associated with an 8.38-fold [95% confidence interval (CI), 3.83–18.34, p < 0.001] and 3.31-fold (95% CI, 1.56–7.04, p = 0.001) increase in CSM and decrease in OS, respectively, at a median follow up of 56 months.

Conclusion:

Chromosome 8q harbors the proto-oncogene c-MYC, which can be upregulated by gain of 8q. Our findings suggest that gain of 8q, can predict aggressive tumor phenotype and inferior survival in RCC.
Evolution toward an open value system for smart mobility services
Authors: Casey Thomas R. , Ali-Vehmas Timo , Valovirta Ville
Published: October 2017

The markets around transport and mobility are undergoing significant changes. One of the central drivers for these changes is the deployment of information and communications technology throughout the transport system, which in turn enables a wide range of smart mobility services. At the moment, however, smart mobility services are rather fragmented and work in isolated silos. A key issue in future development is how these isolated systems will become interconnected and in general more open. In this article, we apply the framework introduced by Ali-Vehmas and Casey (2012) to model how the evolution toward an open value system for smart mobility services could occur in Finland. In particular, we apply analogies from the emergence of GSM-based mobile networks and the Internet where the former has followed a more centralized path and the latter a more decentralized path.1
“Our Greatest Songs Are Still Unsung”: Educating Citizens About Schooling in a Multicultural Society
Authors: Goldin Simona , Flynn Erin Elizabeth , Mehan Egan Cori
Published: October 2017

This study examines how a practice-based unit informs undergraduates’ understandings of the dynamics of teaching and learning in a multicultural society, and how these intersect with equity in U.S. classrooms. Citizens’ nuanced understanding of teaching and learning is increasingly important for their engagement with U.S. schools. Practice-based opportunities can allow students to “see” the complexity of teaching and to challenge assumptions about teaching and learning, which are central to preparing an informed citizenry. Findings further suggest that a single course is not sufficient to expand undergraduate students’ understanding of the role of diversity in social life. More concentrated and ongoing efforts may be needed to make racial, ethnic, economic, and cultural differences salient to students, especially those who have attended largely homogeneous school contexts such as the students in this study.
Spanish Consensus Statement: Clinical Management and Treatment of Tendinopathies in Sport
Authors:   Spanish Group for Tendon Consensus, Fernandez-Jaén Tomas , Rey Guillermo Álvarez , Angulo Francisco , Cuesta Jordi Ardevol , Loureda Rafael Arriaza , España Fernando Ávila , Ayala Juan , Matas Ramón Balius , Pazos Fernando Baró , de Dios Beas Jiménez Juan , Rosell Jorge Candel , Fernandez César Cobián , del Pilar Doñoro Cuevas Mª , Ros Francisco Esparza , Colmenero Josefina Espejo , de Prado Jorge Fernández , García Cota Juan José , Garrido González Jose Ignacio , de Vega Carlos Gonzalez , Santander Manuela González , Herrador Munilla Miguel Ángel , Ruiz Francisco Ivorra , Díaz Fernando Jiménez , Fernandez Antonio Maestro , Marqueta Pedro Manonelles , Muñoz Benito Juan José , Vilás Ramón Olivé , Pedret Carles , Teres Xavier Peirau , Amaro José Peña , Grifell Jordi Puigdellivoll , San Roque Juan Pérez , Parenteu Christophe Ramírez , Serna Juan Ribas , Font Gil Rodas , Álvarez Mikel Sánchez , Marchori Carlos Sanchez , Perez Lluis Til , Durán Rosario Ureña , Valle Soto Miguel del , Villalón Alonso José María , García Pedro Guillen
Published: October 2017

On October 15, 2016, experts met at Clínica CEMTRO in Madrid, Spain, under the patronage of the Spanish Society for Sports Traumatology (SETRADE), the Spanish Society of Sports Medicine (SEMED), the Spanish Association of Medical Services for Football Clubs (AEMEF), the Spanish Association of Medical Services for Basketball Clubs (AEMB), F.C. Barcelona, and Clínica CEMTRO. The purpose was to consider the most appropriate clinical management and treatment of tendinopathies in sports, based on proven scientific data described in the medical literature as well as on each expert’s experience. Prior to the meeting, each expert received a questionnaire regarding clinical management and treatment of tendinopathies in sports. The present consensus document summarizes the answers to the questionnaire and the resulting discussion and consensus regarding current concepts on tendinopathies in sports.
SLAMF7-CAR T cells eliminate myeloma and confer selective fratricide of SLAMF7+ normal lymphocytes
Authors: Gogishvili Tea , Danhof Sophia , Prommersberger Sabrina , Rydzek Julian , Schreder Martin , Brede Christian , Einsele Hermann , Hudecek Michael
Published: October 2017

Key Points

SLAMF7-CAR T cells are effective against proteasome inhibitor/immunomodulatory drug–refractory myeloma. SLAMF7-CAR T cells confer fratricide of SLAMF7+/high normal lymphocytes.
Effect of VS predictors on amplitude variation with offset response
Authors: Arévalo-López Humberto S. , Wollner Uri , Dvorkin Jack P.
Published: October 2017

We have posed a question whether the differences between various [Formula: see text] predictors affect one of the ultimate goals of [Formula: see text] prediction, generating synthetic amplitude variation with offset (AVO) gathers to serve as a calibration tool for interpreting the seismic amplitude for rock properties and conditions. We address this question by evaluating examples in which we test several such predictors at an interface between two elastic layers, at pseudowells, and at a real well with poor-quality S-wave velocity data. The answer based on the examples presented is that no matter which [Formula: see text] predictor is used, the seismic responses at a reservoir are qualitatively identical. The choice of a [Formula: see text] predictor does not affect our ability (or inability) to forecast the presence of hydrocarbons from seismic data. We also find that the amplitude versus angle responses due to different predictors consistently vary along the same pattern, no matter which predictor is used. Because our analysis uses a “by-example” approach, the conclusions are not entirely general. However, the method of comparing the AVO responses due to different [Formula: see text] predictors discussed here is. Hence, in a site-specific situation, we recommend using several relevant predictors to ascertain whether the choice significantly affects the synthetic AVO response and if this response is consistent with veritable seismic data.
Modeling scattering effects from time-varying sea surface based on acoustic reciprocity
Authors: Cecconello Elsa , Asgedom Endrias G. , Orji Okwudili C. , Pedersen Morten W. , Söllner Walter
Published: October 2017

In marine seismic processing, the sea surface is often considered a flat mirror; hence, the effects of different weather conditions during the acquisition are largely ignored. However, studies have shown that rough sea-surface ghosts can severely damage the 4D signal, if not handled properly in data processing. To account for realistic sea-surface effects in processing, the impact of time-varying rough sea surfaces needs to be studied. We derive a method for modeling source and receiver ghosts from the time-varying rough sea surface and their interaction with subsurface reflections. This method is based on acoustic reciprocity and leads to integral equations of nonstationary wavefields. These modeling equations can also serve as a basis for investigating source and receiver deghosting methods for time-varying rough sea surfaces. Our developed modeling algorithm is validated against a frequency-domain approach for a “frozen” rough sea surface. For a moving simple sea surface, the Doppler shift produced by our method is in very good agreement with the analytical solution. Using a Pierson-Moskowitz spectrum, we derive a time-varying rough sea surface and model the receiver ghost, the source ghost, and the source-receiver ghost for the subsurface primary reflections of a heterogeneous geologic model. The results highlight that the source and receiver ghost interactions with a time-varying sea surface differently affect the subsurface reflections, and these effects can significantly impact the seismic repeatability of 4D studies.
Multispectral coherence
Authors: Li Fangyu , Qi Jie , Lyu Bin , Marfurt Kurt J.
Published: October 2017

Seismic coherence is a routine measure of seismic reflection similarity for interpreters seeking structural boundary and discontinuity features that may be not properly highlighted on original amplitude volumes. One mostly wishes to use the broadest band seismic data for interpretation. However, because of thickness tuning effects, spectral components of specific frequencies can highlight features of certain thicknesses with higher signal-to-noise ratio than others. Seismic stratigraphic features (e.g., channels) may be buried in the full-bandwidth data, but can be “lit up” at certain spectral components. For the same reason, coherence attributes computed from spectral voice components (equivalent to a filter bank) also often provide sharper images, with the “best” component being a function of the tuning thickness and the reflector alignment across faults. Although one can corender three coherence images using red-green-blue (RGB) blending, a display of the information contained in more than three volumes in a single image is difficult. We address this problem by combining covariance matrices for each spectral component, adding them together, resulting in a “multispectral” coherence algorithm. The multispectral coherence images provide better images of channel incisement, and they are less noisy than those computed from the full bandwidth data. In addition, multispectral coherence also provides a significant advantage over RGB blended volumes. The information content from unlimited spectral voices can be combined into one volume, which is useful for a posteriori/further processing, such as color corendering display with other related attributes, such as petrophysics parameters plotted against a polychromatic color bar. We develop the value of multispectral coherence by comparing it with the RGB blended volumes and coherence computed from spectrally balanced, full-bandwidth seismic amplitude volume from a megamerge survey acquired over the Red Fork Formation of the Anadarko Basin, Oklahoma.
Cortical interneuron development: a tale of time and space
Authors: Hu Jia Sheng , Vogt Daniel , Sandberg Magnus , Rubenstein John L.
Published: October 2017

Cortical interneurons are a diverse group of neurons that project locally and are crucial for regulating information processing and flow throughout the cortex. Recent studies in mice have advanced our understanding of how these neurons are specified, migrate and mature. Here, we evaluate new findings that provide insights into the development of cortical interneurons and that shed light on when their fate is determined, on the influence that regional domains have on their development, and on the role that key transcription factors and other crucial regulatory genes play in these events. We focus on cortical interneurons that are derived from the medial ganglionic eminence, as most studies have examined this interneuron population. We also assess how these data inform our understanding of neuropsychiatric disease and discuss the potential role of cortical interneurons in cell-based therapies.
Transcriptional precision and accuracy in development: from measurements to models and mechanisms
Authors: Bentovim Lital , Harden Timothy T. , DePace Angela H.
Published: October 2017

During development, genes are transcribed at specific times, locations and levels. In recent years, the emergence of quantitative tools has significantly advanced our ability to measure transcription with high spatiotemporal resolution in vivo. Here, we highlight recent studies that have used these tools to characterize transcription during development, and discuss the mechanisms that contribute to the precision and accuracy of the timing, location and level of transcription. We attempt to disentangle the discrepancies in how physicists and biologists use the term ‘precision' to facilitate interactions using a common language. We also highlight selected examples in which the coupling of mathematical modeling with experimental approaches has provided important mechanistic insights, and call for a more expansive use of mathematical modeling to exploit the wealth of quantitative data and advance our understanding of animal transcription.
An interview with Christiane Nüsslein-Volhard
Authors: Brown Katherine
Published: October 2017

Christiane Nüsslein-Volhard is Director Emeritus at the Max Planck Institute for Developmental Biology in Tübingen, Germany. In 1995, she was awarded the Nobel Prize for Physiology and Medicine, along with Eric Wieschaus and Edward Lewis, for her work on the genetic control of embryogenesis using the fruit fly Drosophila melanogaster. In the 1990s, she transitioned her lab to working with zebrafish (Danio rerio), using similar forward genetic approaches to those that had proved so successful in Drosophila to uncover key regulators of vertebrate development. We met with Christiane at the recent International Society for Developmental Biology (ISDB) meeting in Singapore, to talk about her research, the impact of the Nobel Prize and the challenges of being a ‘woman in science’.
Does penile rehabilitation have a role in the treatment of erectile dysfunction following radical prostatectomy?
Authors: Blecher Gideon , Almekaty Khaled , Kalejaiye Odunayo , Minhas Suks
Published: October 2017

In men undergoing radical treatment for prostate cancer, erectile function is one of the most important health-related quality-of-life outcomes influencing patient choice in treatment. Penile rehabilitation has emerged as a therapeutic measure to prevent erectile dysfunction and expedite return of erectile function after radical prostatectomy. Penile rehabilitation involves a program designed to increase the likelihood of return to baseline-level erectile function, as opposed to treatment, which implies the therapeutic treatment of symptoms, a key component of post–radical prostatectomy management. Several pathological theories form the basis for rehabilitation, and a plethora of treatments are currently in widespread use. However, whilst there is some evidence supporting the concept of penile rehabilitation from animal studies, randomised controlled trials are contradictory in outcomes. Similarly, urological guidelines are conflicted in terms of recommendations. Furthermore, it is clear that in spite of the lack of evidence for the role of penile rehabilitation, many urologists continue to employ some form of rehabilitation in their patients after radical prostatectomy. This is a significant burden to health resources in public-funded health economies, and no effective cost-benefit analysis has been undertaken to support this practice. Thus, further research is warranted to provide both scientific and clinical evidence for this contemporary practice and the development of preventative strategies in treating erectile dysfunction after radical prostatectomy.
Hiring Molecules, Not Atoms: Comobility and Wages
Authors: Marx Matt , Timmermans Bram
Published: October 2017

What role do social connections play in the labor market? A vast, influential literature has detailed the ways in which ties facilitate the flow of information about job opportunities to workers as well as endorsements or referrals of workers to firms. We propose that this role is not constrained to an informational one alone. Rather, relationships between workers can enable a collective job-matching process that facilitates the transfer of shared human capital from one organization to another. Yet “comobility” has been studied only occasionally and among elite workers in particular industries. This study delivers both fieldwork as well as large-sample analysis among all nongovernmental workers in Denmark, finding a 5.5% wage premium for those who move jointly instead of independently, both in the full sample as well as when applying strict matching or fixed effects for workers or firms. Co-movers whose skills are related but not identical capture a higher premium, and the wage gains associated with comobility are not limited to highly skilled workers but rather obtain across a wide range of occupations. Robustness tests establish that the wage premium associated with comobility is not driven by efforts to capture “prized” workers, by employee referrals, or by aggressive hiring by firms. This study provides the first quantification of the anticipated value of comobility, suggesting that both workers and firms may want to revisit individualistic assumptions about how labor markets function. More broadly, our findings show that social relationships can transfer not only information but jointly held human capital across organizational boundaries.
Preserving the independence of people living with multiple sclerosis towards the end of life
Authors: Costello John
Published: October 2017

Background:

Multiple sclerosis (MS) is the most common neurological disease affecting the central nervous system. It has several subtypes. The condition's pathophysiology can involve many body systems, but there are common symptoms. Treatment is both conventional and unconventional, including the controversial use of medicinal cannabis to control pain. Diagnosis can be difficult, as a case study illustrates. Support services are available to patients and carers in the form of MS support groups. People with MS contribute towards their own sense of wellbeing in a number of ways, and a key feature of survivorship with MS is the development of a positive attitude and a sense of hope. Palliative care involves facilitating a good quality of life as the condition progresses into the advanced stages. Invariably, people with MS wish to spend their last days at home among their loved ones. Numerous issues arise around end-of-life care and the role of the nurse in providing palliative care, which includes support needed by lay caregivers, who are often family members. This article will appear as a chapter in Adult Palliative Care for Nursing, Health and Social Care, edited by John Costello, to be published by SAGE Publications Ltd in 2018. It is reproduced with kind permission of SAGE Publications Ltd.
Research roundup
Authors: Costello John
Published: October 2017

Synopses of a selection of recently published research articles of relevance to palliative care.
Politics and palliative care: Cameroon
Authors: Smyth Dion
Published: October 2017

Dion Smyth's review of palliative nursing on the internet
Health effects of informal caring in New Zealand: longitudinal findings from the Health, Work and Retirement study
Authors: Alpass Fiona , Szabo Agnes , Allen Joanne , Stephens Christine
Published: October 2017

This study investigates changes in the mental and physical health of carers compared to non-carers over 10 years in a sample of New Zealanders aged 54–70. Mental health increased slightly over time for all participants but there was no difference in trajectory change based on carer status except for those who stopped caring. No significant differences in physical health or differences in trajectory change for physical health across time based on caregiver status were found. Results provide some support for a health selection bias into caring and the adaptation hypothesis of caring across time.
Práticas intergeracionais e interdisciplinares na Educação. Um exemplo prático no Ensino Básico
Authors: Mendes Pedro Cabral , Leandro Cristina Rebelo , Lopes Mónica
Published: October 2017

O presente artigo tem como finalidade apresentar uma experiência educativa de âmbito intergeracional e interdisciplinar, dinamizada no âmbito do projeto “InterAgir com a Diferença”, envolvendo a participação de 20 alunos do 5º ano e 8 idosos. Esperava-se que a abordagem prosseguida tivesse um efeito positivo no desempenho escolar dos alunos e induzisse comportamentos positivos perante a condição de idoso. Neste estudo de caso, a avaliação do desempenho académico baseou-se na comparação das classificações das disciplinas nos 1º e 2º períodos letivos, e a avaliação qualitativa foi suportada por focus groups com alunos. Os dados quantitativos foram analisados com recurso ao teste ANOVA de medidas repetidas e os qualitativos através da análise de conteúdo temática. O estudo evidenciou os benefícios destas práticas que, não só reforçam a motivação e os resultados escolares, como também fomentam nos alunos atitudes e comportamentos positivos perante a velhice, reforçando o exercício da cidadania ativa.
Desenvolvimento in vitro da orquídea ameaça de extinção Laelia marginata Lindl. em meios de cultivo contendo diferentes relações nitrato/amônio
Authors: Bertoncelli Douglas Junior , Alves Guilherme Augusto Cito , Hoshino Rodrigo Thibes , Freiria Gustavo Henrique , Furlan Felipe Favoretto , Stegani Vanessa , De Faria Ricardo Tadeu
Published: October 2017

In vitro cultivation is a very important method for the conservation of germplasm and the multiplication of endangered plants; however, studies on the adequacy of the nutrients used for a good development of each species are needed. The objective of this study was to evaluate the in vitro development of Laelia marginata Lindl. in culture media containing different nitrate/ ammonium ratios. Seedlings were obtained from seeds germinated in vitro. The treatments consisted of different nitrate/ ammonium ratios, with five proportions of NO3 - and NH4 + : T1-0/100; T2-25/75; T3-50/50; T4-75/25 and T5-100/0. At 200 days after seedling transplanting, height of the aerial part, root length, number of leaves, number of shoots, leaf length, leaf width, aerial and root dry mass and contents of chlorophyll a, b and carotenoids were evaluated. A completely randomized design was used, with five treatments and ten replicates. The combination of 50/50 nitrate/ammonium resulted in the highest values of aerial part and root length, dry mass of the aerial part and root, as well as leaf length and width. The proportion of 50/50 nitrate/ammonium resulted in the best initial development of L. marginata seedlings.
Correlação entre dados de perfilagem geofísica e potencial de bombeamento de poços em litotipos da Formação Cauê no sudoeste do Quadrilátero Ferrífero, MG
Authors: Dantas Júlia Cotta Maciel , Mesquita Daniele Costa de , Paula Rodrigo Sergio de , Guerra Kênia Janete
Published: October 2017

O presente artigo consiste em uma integração litológica-hidrológica com base em dados de perfilagem geofísica realizada em poços tubulares profundos. Seu principal objetivo é a comparação e definição dos litotipos mais favoráveis para prospecção de água subterrânea na área de estudo. A metodologia envolveu a análise dos perfis geofísicos e sua interpretação em conjunto com a litologia e valores de vazão específica de cada poço.  No caso dos litotipos do Aquífero Cauê, as litologias brandas tendem a ter mais água que litologias compactas e, de modo geral, hematitas são mais ricas em água do que itabiritos, ainda que, a quantidade de água nos diferentes tipos de itabirito tenha uma boa variação.
Efficacy of various administrative techniques of methylprednisolone on oedema, trismus and pain after lower third molar surgery
Authors: Mukund Vaibhav , Singh Sukumar , Kumar Sanjeev , Rath Rishi , Tevatia Siddharth
Published: October 2017

Due to their anatomical position, the surgical removal of impacted third molars results in oedema, pain, and trismus. The purpose of this study was to evaluate the efficacy of four different routes of administration of methylprednisolone on oedema, trismus and pain after lower third molar surgery. This randomized, perspective, and controlled study included 150 patients. The patients were randomly divided into five groups: Group A (control; no steroids), Group B (Submucosal injection), Group C (oral tablets), Group D (i.v. injection) and Group E (Intramuscular Injection). On days 2 and 7 following surgery, linear oedema was determined using facial landmarks, and maximal mouth opening was measured. Postoperative mouths opening and swelling were evaluated for each route of methylprednisolone administration and compared. The female (59%) to male (41%) ratio was 1.44; the mean age of the patients was 29.6 years. The level of significance was set at P < 0.01 for mouth opening and P < 0.05 for oedema. With regard to trismus, all four routes of administration demonstrated better efficacy in comparison to the control. While oral administration and i.v. injection of methylprednisolone achieved similar results, masseter injection provided better results in reducing oedema and trismus when compared with the control following lower third molar surgery.
Dabigatran-Induced Spontaneous Hemopericardium and Cardiac Tamponade
Authors: Jelani Qurat-ul-ain , Gordon Ram , Schussheim Adam
Published: October 2017

Four novel oral anticoagulant agents are currently available for the prevention and treatment of thromboembolic events in patients with nonvalvular atrial fibrillation. We present an unusual case of spontaneous hemopericardium and tamponade in an 87-year-old man with atrial fibrillation who was taking one such agent, dabigatran, as thromboprophylaxis.

Our case highlights both a rare bleeding complication of dabigatran use and the effectiveness of idarucizumab, its newly approved reversal agent. Especially in elderly patients, we recommend that clinicians evaluate risk factors, closely monitor patient status, and consider alternatives to the newer anticoagulants when the risk of bleeding is high.
Evaluation of violence against women in the context of analytic psychotherapy
Kadına yönelik şiddetin analitik psikoterapi bağlamında değerlendirilmesi
Authors: Bozdağ Faruk , Voltan Acar Nilüfer
Published: October 2017

In this study, it was aimed to evaluate violence against women, one of the common problems of the society, especially in the context of analytical psychotherapy, based on some recent events in the media. For this purpose, two cases involving violence against women were discussed with the basic approach of analytical psychotherapy. In the study, the emotions, thoughts and behaviors of violent men were tried to be explained based on the concepts of conscious, unconscious, complex and archetypes of analytical psychotherapy. As a result, in this study, some clues about the points that psychological counselors should take into consideration in the psychological treatment of men who resort to violence against women.Extended English abstract is in the end of PDF (TURKISH) file. ÖzetBu çalışmada toplumun yaygın sorunlarından biri olan kadına yönelik şiddetin özellikle son zamanlarda medyada yer alan bazı olaylar temel alınarak analitik psikoterapi bağlamında değerlendirilmesi amaçlanmıştır. Bu amaçla kadına yönelik şiddeti içeren iki olay, analitik psikoterapinin temel yaklaşımıyla ele alınmıştır. Çalışmada şiddet uygulayan erkeklerin duygu, düşünce ve davranışları analitik psikoterapinin bilinç, bilinçdışı, kompleks ve arketip kavramları esas alınarak açıklanmaya çalışılmıştır. Sonuç olarak bu çalışmada kadına yönelik şiddet uygulayan erkeklerin psikolojik tedavilerinde psikolojik danışmanların göz önünde bulundurmaları gereken noktalara ilişkin bir takım ipuçları ortaya çıkmıştır.
Violência de gênero no contexto escolar: refletindo sobre estratégias de enfrentamento através da extensão universitária
Authors: Da Silva Caroline Fernanda Santos , Moraes Andriele Rodrigues , Da Silva Rocha Katia Glashorester
Published: October 2017

Este trabalho apresenta algumas reflexões suscitadas a partir da aplicação do projeto de extensão universitária do curso de Serviço Social da ULBRA, intitulado: “Promoção da Paz e Estratégias de Enfrentamento à Violência de Gênero nas Escolas”, no período de 2016-1. Apresentamos algumas das situações vivenciadas pelas alunas extensionistas e pela professora coordenadora do projeto durante o “jogo de tabuleiro”, metodologia desenvolvida junto aos alunos do Ensino Médio da cidade de Canoas/RS, em uma escola da rede estadual de ensino. Para oferecer subsídios à discussão, este trabalho apresenta também algumas reflexões sobre a conjuntura econômica, política e social do país e do estado do Rio Grande Sul; bem como uma discussão sobre a violência de gênero e a culpabilização da mulher na sociedade atual, bem como o papel da extensão universitária nesse contexto.
Heteronormatividade e abjeção na escola: reflexões construídas junto a um grupo LGBTT no interior de São Paulo
Authors: Brancaleoni Ana Paula Leivar , Amorim Sylvia Maria Godoy
Published: October 2017

Vivemos em uma sociedade pautada no dispositivo cultural de poder da heteronormatividade. Assim, a homofobia e a transfobia, frequentemente já vivenciadas na família, são reproduzidas na escola. No presente trabalho, pretende-se construir compreensões sobre as vivências escolares de um grupo LGBTT, que enfrentam condições de vulnerabilidade, na relação com a heteronormatividade, assim como elencar elementos importantes para a construção de um cotidiano escolar em que caiba a diversidade sexual e de gênero. Adotou-se uma abordagem de cunho cartográfico. O trabalho com o grupo foi desenvolvido em um centro de referência a pessoas em situação de rua que frequentavam o local para refeições e banho. Os encontros foram semanais ao longo de um ano. Utilizaram-se como instrumentos de coleta de dados: o diário de bordo e entrevistas. Constatou-se que as histórias demonstram com intensidade a ação da heteronormatividade enquanto dispositivo cultural de poder, legitimando hierarquizações e processos de exclusão e violência. A transfobia e homofobia resultaram em processos de isolamento e expulsão da escola, assim como da negação das condições básicas de aprendizado, expressas no não domínio da escrita e da leitura. Ao longo do trabalho desenvolvido, destacou-se o potencial do trabalho em grupo, através do qual puderam reconhecer e reinterpretar as próprias dores, entendendo-se como sujeitos que possuem uma história que merece ser contada e que apresenta um potencial de ajuda a outras pessoas que vivenciam condições semelhantes.
EDUCAÇÃO A DISTÂNCIA CENTRADA NA APRENDIZAGEM: REFLEXÕES SOBRE ENSINO, PESQUISA E EXTENSÃO
Authors: Rodriguez Lilian Lorenzato , Júnior Álvaro Veiga , Cardoso Adriana Lessa , Araújo Pâmela Renata Machado
Published: October 2017

O trabalho objetiva propor reflexões a respeito da possibilidade de integração entre ensino, pesquisa e extensão tendo por base suas experiências  docentes de professoras formadoras no Curso de Licenciatura em Pedagogia a Distância, CLPD/UFPEL. O quadro teórico-metodológico se constitui na perspectiva da Pedagogia Popular e Problematizadora de Paulo Freire e na compreensão das atuais políticas públicas para a educação. Este ensaio se pauta nas metodologias qualitativas em educação, especialmente na perspectiva de práxis pedagógica e de ciclos gnosiológicos  para propor os entendimentos acordados, não pretendendo certificar verdades, mas sim motivar diálogos. Tais reflexões procuram reunir o posicionamento das professoras formadoras em seu movimento dialético-dialógico entre prática, teoria e prática e, ação, reflexão e ação;  ao vivenciarem os ciclos gnosiológicos. Entendemos que este curso é um exemplo de interação entre diferentes dimensões sociais e culturais, pois a concepção utilizada de Ead, centrada na aprendizagem construtiva e cooperativa, realimentada pela práxis pedagógica crítica e emancipadora, nos permitiram vivenciar diferentes intensidades e frequências de articulação dos três pilares da ciência Brasileira. As noções integradoras, aquelas que favorecem o entendimento de totalidades interdependentes  e dinâmicas, permitem o diálogo crítico entre dimensões globais e locais, dimensões ambientais, econômicas e sociais, desta maneira, favorecem por sua vez uma percepção e consciência que superem a alienação, fragmentação, efemeridade e o individualismo. Os sujeitos da educação ao conhecerem a realidade concreta cultural e historicamente podem superar a sua condição ingênua e assim transformarem-se e transformá-la.
Slave Religiosity in the Roman Middle Republic
Authors: Peralta Dan-el Padilla
Published: October 2017

This article proposes a new interpretation of slave religious experience in mid-republican Rome. Select passages from Plautine comedy and Cato the Elder's De agri cultura are paired with material culture as well as comparative evidence—mostly from studies of Black Atlantic slave religions—to reconstruct select aspects of a specific and distinctive slave “religiosity” in the era of large-scale enslavements. I work towards this reconstruction first by considering the subordination of slaves as religious agents (Part I) before turning to slaves’ practice of certain forms of religious expertise in the teeth of subordination and policing (II and III). After transitioning to an assessment of slave religiosity's role in the pursuit of freedom (IV), I conclude with a set of methodological justifications for this paper's line of inquiry (V).
Exploration of the impact of nearby sources on urban atmospheric inversions using large eddy simulation
Authors: Gaudet Brian J. , Lauvaux Thomas , Deng Aijun , Davis Kenneth J.
Published: October 2017

The Indianapolis Flux Experiment (INFLUX) aims to quantify and improve the effectiveness of inferring greenhouse gas (GHG) source strengths from downstream concentration measurements in urban environments. Mesoscale models such as the Weather Research and Forecasting (WRF) model can provide realistic depictions of planetary boundary layer (PBL) structure and flow fields at horizontal grid lengths (Δx) down to a few km. Nevertheless, a number of potential sources of error exist in the use of mesoscale models for urban inversions, including accurate representation of the dispersion of GHGs by turbulence close to a point source.

Here we evaluate the predictive skill of a 1-km chemistry-adapted WRF (WRF-Chem) simulation of daytime CO2 transport from an Indianapolis power plant for a single INFLUX case (28 September 2013). We compare the simulated plume release on domains at different resolutions, as well as on a domain run in large eddy simulation (LES) mode, enabling us to study the impact of both spatial resolution and parameterization of PBL turbulence on the transport of CO2. Sensitivity tests demonstrate that much of the difference between 1-km mesoscale and 111-m LES plumes, including substantially lower maximum concentrations in the mesoscale simulation, is due to the different horizontal resolutions. However, resolution is insufficient to account for the slower rate of ascent of the LES plume with downwind distance, which results in much higher surface concentrations for the LES plume in the near-field but a near absence of tracer aloft. Physics sensitivity experiments and theoretical analytical models demonstrate that this effect is an inherent problem with the parameterization of turbulent transport in the mesoscale PBL scheme. A simple transformation is proposed that may be applied to mesoscale model concentration footprints to correct for their near-field biases. Implications for longer-term source inversion are discussed.
Apparitional Movements as Sites of Religious Experimentation
Authors: Halemba Agnieszka
Published: October 2017

Based on an analysis of existing literature on Marian apparitions and field research-based case study from contemporary Transcarpathian Ukraine, this article asserts that an interpretation of Marian apparitional movements as a form of acquiescence to the authoritarian and conservative vision of the Catholic Church is too simplistic. The Virgin Mary appears in moments of crisis that are often caused or exacerbated by conflicts, especially ecclesiastical ones and it is also true that the sites of apparitions often do give a voice to those critical of modern changes. However, they are not always instrumentalized in support of conservative ideas. To the contrary, Marian apparitions are often sites of religious experimentation and innovation. On the one hand the Church can be extremely skeptical of or even hostile to apparitional events, still on the other hand the Church makes use of them as places of religious modernization with an aim to revitalize religious adherence.
Marian Apparitions as New Religious Movements
Authors: Krebs Jill M. , Laycock Joseph
Published: October 2017

Marian apparitions, as diverse, global, and dynamic phenomena, offer opportunities for multi-disciplinary and cross-cultural analysis. We are pleased in this special issue to offer seven essays highlighting the increasing internationalization of Marian devotional movements. Our contributors, using both local case studies and a global, comparative view to explore instances of apparitions in North America, Europe, Asia, and Australia, collectively indicate three major points. First, apparitional movements are globally-connected, complex, and multi-layered. Second, apparitional movements are situated among so many social and political nodes that they are diverse, even internally, and therefore difficult to categorize. Third, apparitions are informed by both grassroots activism and institutional religious structures. These themes challenge categories in the study of religion, including disciplinary categories, and pose questions for further research.
Espacios de poder: orden familiar, nobleza y uso de los derechos patrimoniales en la Barcelona moderna
Authors: Fargas Peñarrocha María Adela
Published: October 2017

A partir de la idea de la existencia de relaciones de autoridad en el seno de células políticas primarias, como son el ámbito doméstico y familiar, se estudia en este artículo una de las formas principales del ejercicio de dichas relaciones en una muestra de familias de las clases privilegiadas vinculadas a la Barcelona moderna. La forma de ejercicio de poder sobre la que nos centramos era la generada por los actos patrimoniales. Para su estudio utilizamos diversa categoría de documentación producida como consecuencia de la conflictividad familiar. Se observa que el sistema de exclusión, no sólo determina la concentración del poder familiar, poder que se ostenta en numerosos acontecimientos familiares y especialmente en el intervencionismo practicado sobre los núcleos familiares dependientes, sino que ordena los canales por donde discurre la movilidad patrimonial. Las relaciones de parentesco creaban una particular e informal lógica costumbrista, donde el poder de los que controlaban los patrimonios decidía y ordenaba las posibilidades de cada uno de los miembros de la comunidad familiar. La mujer constituirá un elemento clave en la concentración del poder patrimonial cuando se refuerza el control sobre su dote. A la muerte del marido, pero sobre todo de aquél que había ostentado el lugar de heredero, tenía ocasión una especie de circulación de autoridad. El orden familiar era concebido, más que en términos de equilibrios, de subordinaciones. Y era en la subordinación, en las relaciones de poder, donde se buscaba el orden.
La historiografía occidental en el año 2000. Elementos para un balance global
Authors: Aguirre Rojas Carlos Antonio
Published: October 2017

Este articulo intenta reconstruir un panorama global de lo que es hoy el paisaje de los estudios históricos en el mundo occidental. lnterrogándose acerca del mapa complejo de lo que es hoy esta historiografía más actual, el autor propone la ubicación de varios `polos fuertes' que, vinculados a las principales revistas de historia en este mundo occidental, constituyen hoy espacios de fuerte irradiación de la innovación historiográfica y de la apertura de las nuevas temáticas abordadas por los historiadores. Finalmente, el articulo esboza también algunos de los `polos emergentes' de esta misma historiografía, que en los tiempos por venir podrán quizá llegar a ser los nuevos 'polos fuertes' de la futura renovación historiográfica.
El Ferrol y su tierra durante el Antiguo Régimen. Un estudio sobre población y sociedad
Authors: Martín Alfredo
Published: October 2017

La decisión de la Corona, a mediados del siglo XVIII, de crear en el puerto de El Ferrol los arsenales más importantes de su Armada, trajo consigo una serie de cambios muy destacados desde el punto de vista demográfico, social o económico, tanto en la localidad como en su entorno más inmediato. La villa se transformó en un corto período de tiempo en el centro urbano más populoso del Reino de Galicia, merced a la fuerza del flujo inmigratorio. Del mismo modo, su estructura socioeconómica varió por completo, primando a partir de ese momento las profesiones ligadas de manera directa o indirecta a la Armada y a la construcción naval, en detrimento de las actividades vinculadas al sector primario.