bluuebunny/crossref_metadata_2025 huggingface dataset:
Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth
Authors: Malireddi R K Subbarao , Karki Rajendra , Sundaram Balamurugan , Kancharana Balabhaskararao , Lee SangJoon , Samir Parimal , Kanneganti Thirumala-Devi
Published: July 2021

Resistance to cell death is a hallmark of cancer. Immunotherapy, particularly immune checkpoint blockade therapy, drives immune-mediated cell death and has greatly improved treatment outcomes for some patients with cancer, but it often fails clinically. Its success relies on the cytokines and cytotoxic functions of effector immune cells to bypass the resistance to cell death and eliminate cancer cells. However, the specific cytokines capable of inducing cell death in tumors and the mechanisms that connect cytokines to cell death across cancer cell types remain unknown. In this study, we analyzed expression of several cytokines that are modulated in tumors and found correlations between cytokine expression and mortality. Of several cytokines tested for their ability to kill cancer cells, only TNF-α and IFN-γ together were able to induce cell death in 13 distinct human cancer cell lines derived from colon and lung cancer, melanoma, and leukemia. Further evaluation of the specific programmed cell death pathways activated by TNF-α and IFN-γ in these cancer lines identified PANoptosis, a form of inflammatory cell death that was previously shown to be activated by contemporaneous engagement of components from pyroptosis, apoptosis, and/or necroptosis. Specifically, TNF-α and IFN-γ triggered activation of gasdermin D, gasdermin E, caspase-8, caspase-3, caspase-7, and MLKL. Furthermore, the intratumoral administration of TNF-α and IFN-γ suppressed the growth of transplanted xenograft tumors in an NSG mouse model. Overall, this study shows that PANoptosis, induced by synergism of TNF-α and IFN-γ, is an important mechanism to kill cancer cells and suppress tumor growth that could be therapeutically targeted.
Lipoproteins from Staphylococcus aureus Drive Neutrophil Extracellular Trap Formation in a TLR2/1- and PAD-Dependent Manner
Authors: Hook Jessica S , Patel Parth A , O’Malley Aidan , Xie Lihua , Kavanaugh Jeffrey S , Horswill Alexander R , Moreland Jessica G
Published: July 2021

Neutrophils, polymorphonuclear leukocytes (PMN), play a critical role in the innate immune response to Staphylococcus aureus, a pathogen that continues to be associated with significant morbidity and mortality. Neutrophil extracellular trap (NET) formation is involved in ensnaring and killing of S. aureus, but this host–pathogen interaction also leads to host tissue damage. Importantly, NET components including neutrophil proteases are under consideration as therapeutic targets in a variety of disease processes. Although S. aureus lipoproteins are recognized to activate cells via TLRs, specific mechanisms of interaction with neutrophils are poorly delineated. We hypothesized that a lipoprotein-containing cell membrane preparation from methicillin-resistant S. aureus (MRSA-CMP) would elicit PMN activation, including NET formation. We investigated MRSA-CMP–elicited NET formation, regulated elastase release, and IL-8 production in human neutrophils. We studied PMN from healthy donors with or without a common single-nucleotide polymorphism in TLR1, previously demonstrated to impact TLR2/1 signaling, and used cell membrane preparation from both wild-type methicillin-resistant S. aureus and a mutant lacking palmitoylated lipoproteins (lgt). MRSA-CMP elicited NET formation, elastase release, and IL-8 production in a lipoprotein-dependent manner. TLR2/1 signaling was involved in NET formation and IL-8 production, but not elastase release, suggesting that MRSA-CMP–elicited elastase release is not mediated by triacylated lipoproteins. MRSA-CMP also primed neutrophils for enhanced NET formation in response to a subsequent stimulus. MRSA-CMP–elicited NET formation did not require Nox2-derived reactive oxygen species and was partially dependent on the activity of peptidyl arginine deiminase (PAD). In conclusion, lipoproteins from S. aureus mediate NET formation via TLR2/1 with clear implications for patients with sepsis.
Presence of carbepenemase-producing Enterobacteriaceae in the River Lambro basin, Italy: might sediment represent an important resistance reservoir?
Authors: Rimoldi Sara Giordana , Romeri Francesca , Gigantiello Anna , Pagani Cristina , Viganò Luigi , Calvagna Annunziata , Tamoni Alessandro , Maresca Mafalda , Gismondo Maria Rita , Stefani Fabrizio
Published: July 2021

In the last years, the rapid spread in anthropized ecosystems of pathogens which are resistant to carbapenem antibiotics has raised great concern. In this study, KPC-producing Klebsiella pneumoniae was found in the River Lambro in June 2019, whereas KPC-producing Klebsiella oxytoca and Citrobacter braakii were identified in untreated wastewaters. Susceptibility profiles indicated resistance to imipenem, ertapenem and meropenem. Different carbapenamase genes (blaKPC, blaNDM, blaVIM, blaOXA-48) were also found in the River Lambro, although not associated to living bacteria. The presence of a wide set of carbapenemase genes and resistant pathogens show that river sediments could act as a reservoir of antibiotic resistance potentially threatening human health.
Correlates of Sedentary Behavior among Bhutanese Adults: Findings from the 2014 Bhutan STEPS Survey Data
Authors: Dendup Tashi , Zhao Yun , Edi Putra I Gusti Ngurah , Dorji Tandin , Tenzin Chador
Published: July 2021

Background: Sedentary behavior is associated with several adverse health outcomes. Data on factors that influence sedentary behavior are lacking in Bhutan. This study examined factors associated with increased sedentary behavior in Bhutan, with a focus on exploring sex differences.Methods: Data of 2,796 adults from the nationally representative 2014 Bhutan STEP-wise surveillance (STEPS) survey were analyzed. Factors associated with sedentary behavior were identified using backward elimination multiple logistic regression analysis, disaggregated by sex. The analysis accounted for the complex survey design used in the primary survey.Results: The overall prevalence of sedentary behavior was 8.2%, with a higher proportion among women than men (10.3% vs. 4.9%). In the full sample, female sex, being single, high education and income, urban residence, inadequate physical activity, and high blood sugar were associated with increased odds of sedentary behavior. Among females, those who had high education and income, were single, physically less active, and urban residents were more likely to be sedentary. Self-employment was related to reduced odds of sedentary behavior among women and in the overall sample population. In males, being single, higher education level, and urban residence were associated with sedentariness.Conclusion: The findings suggest that interventions targeting females, especially those who are physically less active and from higher socioeconomic groups, urban residents, and those with hyperglycemia can potentially help reduce sedentary behavior and avert the associated detrimental impacts.
Validation of the Simplified Palliative Prognostic Index to Predict Survival for Advanced Cancer Patients in Home Hospice Setting
Authors: Yang Hyeon-Jeong , Yoon Seok-Joon , Kim Jong-Sung , Kim Sung-Soo , Jung Jin-Gyu , Suh Won Yoon , Lee Sami , Kim Hyun Gu , Lee Yong Woo
Published: July 2021

Background: The simplified Palliative Prognostic Index (sPPI) substitutes a single item from the Communication Capacity Scale (CCS) for the delirium item of the original PPI. This study aimed to examine the validity of the sPPI for patients with advanced cancer in a home-based hospice care setting.Methods: This study included 75 patients with advanced cancer who received home-based hospice care. We used medical records maintained by professional hospice nurses who had visited the patients in their homes. Based on their sPPI score, patients were divided into three groups—A (<4), B (≥4 and <6), and C (≥6)—to compare survival. Further, we investigated the sPPI’s accuracy using the area under the receiver operating characteristic curve (AUC) and sensitivity and specificity for 3- and 6-week survival. We used three sPPIs including different substitutions for the delirium item (two methods using the CCS and one using the Korean Nursing Delirium Screening Scale).Results: The median survival was 60–61 days for group A, 27–30 days for group B, and 12–16 days for group C. The difference in survival was significant (P<0.05). The AUC was 0.814–0.867 for 3-week survival and 0.736–0.779 for 6-week survival. For 3- and 6-week survival, prognostic prediction showed sensitivities of 76.2%–90.9% and 76.3%–86.8%, and specificities of 64.2%–88.7% and 51.4%–70.3%, respectively.Conclusion: The sPPI, which is measured by professional hospice nurses, has acceptable validity to predict survival for patients with advanced cancer in a home hospice setting in South Korea.
The Association between Serum Vitamin D Concentration and Colon Polyp: A Cross-Sectional Study Using Health Care Screening Database in a Tertiary Hospital in Korea
Authors: Yoo Mun Young , Lee Jungkwon , Chung Ji In , Yeo Yohwan , Cho In Young
Published: July 2021

Background: As indoor activity increases with modern lifestyles changes, reduced exposure to sunlight may lead to reduced vitamin D synthesis. Previous studies demonstrated that increased vitamin D level is associated with decreased risk of colon cancer; therefore, this study attempted to determine the association between vitamin D and colon polyps, which may be precancerous lesions, in participants who underwent colonoscopy exams.Methods: A total of 31,004 participants who underwent routine health checkups, including vitamin D level and colonoscopy, at Samsung Medical Center in South Korea from 2010 to 2018 were included in the study. Colorectal polyps were diagnosed through biopsy after performing colonoscopy exams. Participants were categorized into three groups according to level of vitamin D (deficient: <20 ng/mL), insufficient: 20≤ vitamin D <30 ng/mL, and sufficient: ≥30 ng/mL). We analyzed the presence of colorectal polyps according to vitamin D level, and performed multiple logistic regression analyses for the association between vitamin D level and colorectal polyps.Results: About 50% of participants had colorectal polyps (hyperplastic polyp, n=4,864; adenomatous polyp, n=10,470; adenocarcinoma, n=24). There were no significant associations between vitamin D categories and colorectal polyp and colorectal cancer. However, when further analyzing by type of polyp, the risk of hyperplastic polyps significantly decreased with increasing vitamin D levels (P for trend=0.006).Conclusion: We did not find evidence for an association between vitamin D and overall colorectal polyps; however, we observed a trend for decreased odds of hyperplastic polyps with increased vitamin D levels in comparison to vitamin D deficient subjects.
The Association between the Use of Dietary Supplement and Psychological Status of Cancer Survivors in Korea: A Cross-Sectional Study
Authors: Lee Han Rim , Song Yun-Mi , Jeon Keun Hye , Cho In Young
Published: July 2021

Background: Dietary supplements (DS) use is known to be common among cancer survivors. However, detailed information on the factors influencing DS use seems insufficient, including cancer-related and psychological factors.Methods: Study subjects were 1,852 Korean adult cancer survivors recruited from cancer survivor clinic of two university-affiliated hospitals. Data were collected retrospectively through review of medical records and self-administered questionnaires. Psychological factors were assessed using Hospital Anxiety and Depression Scale (HADS) and Fear of Cancer Recurrence Inventory-Short Form. Factors associated the DS use were evaluated by multiple logistic regression analysis after adjusting for covariates.Results: The prevalence of long-term DS use was 15.7% in overall (17.5% in female and 11.6% in male). Female survivors were 3.14 times (95% confidence interval [CI], 1.89–5.22) more likely to use DS than male. In male cancer survivors, ever-smoking and previous radiotherapy were positively associated with DS use. In females, breast cancer survivors were 0.32 times less likely to use DS compared with stomach cancer survivors, and survivors with family history of cancer were 1.39 times more likely to use DS than those without. After adjusting for sociodemographic, clinical, and lifestyle factors, survivors with anxiety (HADS ≥8) used DS 1.38 times (95% CI, 1.01–1.91) more frequently, compared with those without anxiety.Conclusion: Diverse factors such as female sex, cancer treatment modality, smoking history, family history and anxiety status were associated with DS use in Korean cancer survivors. Targeted strategies with consideration of these factors are needed for counseling DS use for cancer survivors.
Метамодерн как новое мировидение: синтез массового и элитарного
Authors: Khlyshcheva Elena V.
Published: July 2021

Статья посвящена сравнительному анализу восприятия элитарности и массовости в эпохи модерна, постмодерна и метамодерна. При этом метамодерн рассматривается как новая эпоха формирования целостного, синкретического, сознания. Метамодернизм являет собой не просто новое течение в художественной культуре и философском дискурсе, но и знаменует смену вех, соответствующую культурно-историческому процессу. Метамодерн не возник на пустом месте и взял на вооружение практики модернизма и постмодернизма. Но если модерн смотрел в будущее, а постмодерн оглядывался назад, то метамодерн созерцает (чувствует) настоящее.
Метамодерн воспринимает мир и культуру как один общий поток смыслов, поэтому возникает потребность не только получать контент - но и переживать его как опыт. Культурная парадигма современности - сращение массового и элитарного. Так современная культура становится серчинговой, вбирая в себя владение методологией поиска информации и ее интерпретации в разных контекстах. Особое внимание привлекает соотношение элитарной и массовой культур как базовых констант современного общества.
Карнавальная политическая культура: пикник на обочине средневековой истории
Authors: Karabushenko Paul L.
Published: July 2021

Карнавальная политическая культура создала немало карикатурных средневековых химер, состоящих из нелепых политиков, невменяемых проповедников, неудачливых и ложных служителей культа, одиозных личностей, искусственных государств, маниакальных сект и т.д., и т.п., что может быть и имели яркую форму, но обладали при этом совершенно непонятным содержанием. Поведение многих должностных политических лиц того времени не соответствовало их официально установленным или фактически сложившимся в данном обществе нормам, стереотипам образцов поведения. Девиация и становилась главным признаком карнавальной политической культуры. Девиация порождала нелепости, слишком много, чтобы этого можно было не замечать. Нелепости возникали и на династийном уровне, и в разрывах культурных, этнических и конфессиональных ценностей, и в народных бунтах. То, что современный человек воспринимает как нелепость, на это человек средневековья мог вообще не обратить никакого внимания. И наоборот - его удивить могло то, что нам в принципе может быть вообще непонятным. 
Религиозный фанатизм и мракобесие предопределяли готическое мировоззрение той эпохи, наполненное всевозможного рода небылицами, горгульями и химерами. И все это одновременно являлось и контекстом политического карнавала, и в то же время наполняло его, становясь теми незримыми нитями, за которые кукловоды дергали своих марионеток. Многое в карнавальной политической культуре было связано с распутством и развратом первых лиц государств, церквей (сект), и различного рода профессиональных корпораций. Анализу этих аномалий и посвящена настоящая работа.
Деятельность международных организаций по подготовке и обучению электоральных экспертов
Authors: Grishin Nikolai V.
Published: July 2021

В статье рассматривается становление и современное состояние деятельности международных организаций в сфере повышения квалификации и обучения электоральных экспертов. В статье впервые раскрывается исследовательская проблема изучения вклада международного сообщества в подготовку кадров для публичного управления в сфере выборов.
Эмпирическими источниками исследования стали данные о работе таких международных акторов, как Учебный и научно-исследовательский институт ООН (UNITAR), ЕС, Организация американских государств, Совет Европы, Международный институт демократии и содействия выборам, Европейский центр поддержки выборов (ECES). 
 Раскрыты предпосылки и потребности в подготовке электоральных экспертов для нужд международных организаций. Уточнены представления о кадровых потребностях международных организаций в электоральных экспертах. Охарактеризованы особенности подходов к обучению электоральных экспертов в практике различных международных организаций. Рассмотрение важнейшие международные проекты, созданные для подготовки электоральных экспертов, такие, как “BRIDGE”, “NEEDS”, “ EODS”.
Результаты исследования подтверждают, что международное сообщество обладает приоритетом в обучении специалистов для публичного управления выборами, в том числе, для национального уровня управления.
Статья рассчитана для специалистов, занимающихся изучением вопросов электоральной политики, глобального управления, международных организаций.
Сталинские «симпосионы» - рецензия на книгу профессора В.А. Невежина «Застолья Иосифа Сталина. Книга первая. Большие кремлевские приемы 1930-х – 1940-х годов»
Authors: Podvoiskaya Natalia L.
Published: July 2021

В представленной работе дается развернутый анализ торжественных мероприятий, проводившихся в сталинскую эпоху. Опираясь на богатейший архивный материал, профессор В.А. Невежин рассматривает значение подобных «приемов» и застольной традиции в деле сплочения партийных кадров и политического руководства сталинской эпохи. Отмечается, что подобные традиции политической культуры складывались постепенно на протяжении 1930-х гг., пока не приобрели свои окончательные очертания, просуществовавшие до самого конца Советской эпохи. Официальные приемы выполняли также и представительские функции – приемы дипломатического корпуса содействовали повышению культурного престижа страны Советов, в особенности его политического руководства.
SOSISALISASI KESEHATAN HEWAN KEPADA MASYARAKAT SECARA DARING
Authors: Indarjulianto Soedarmanto , Yanuartono Yanuartono , Raharjo Slamet , Nururrozi Alfarisa , Wuryastuty Hastari , Widiyono Irkham , Purnamaningsih Hary , Mulyani Guntari Titik , Tjahajati Ida , Hartati Sri , Yuriadi Yuriadi
Published: July 2021

ABSTRACT

 Various animal diseases are not always known by animal owners, so they must always be socialized even in the condition of the COVID-19 outbreak. This community service aims to provide animal health information to the community by online. This activity was carried out from in November 2020 using the Cisco Webex platform. The results showed that as many as 269 participants have joined in the socialization, consisting of 180 from Yogyakarta and 89 from outside Yogyakarta. Concluded that online socialization of animal health is successfully carried out and received a very good response from the community.

 Keywords: Animal health; Community service; Veterinary clinic

 

ABSTRAK

 Berbagai macam penyakit hewan tidak selalu diketahui oleh pemilik hewan, sehingga harus selalu disosialisasikan walapun dalam kondisi wabah COVID-19. Pengabdian kepada masyarakat (PKM) ini bertujuan memberikan informasi kesehatan hewan kepada masyarkat secara daring. Pengabdian dilakukan pada bulan bulan Oktober sampai Nopember 2020 secara daring menggunakan platform Cisco Webex. Hasil PKM menunjukkan bahwa sebanyak 269 calon peserta telah mengikuti sosialisasi, yang terdiri dari 180 berasal dari Yogyakarta dan 89 dari luar Yogyakarta. Berdasar hasil kegiatan ini, disimpulkan bahwa sosialisasi tentang kesehatan hewan secara daring berhasil dilaksanakan dan mendapat respon sangat bagus dari masyarakat.

 Kata kunci: Kesehatan hewan; Klinik hewan; Pengabdian masyarakat.
Um estudo da disciplina História da Educação e suas contribuições para a formação docente no Brasil
Authors: Rodrigues Mônica Soares , Pereira Raimara Gonçalves , Brandão Viviane Bernadeth Gandra
Published: July 2021

Este estudo teve como objetivo levantar dados referentes à presença da disciplina História da Educação e sua importância nos cursos de formação de professores no Brasil. Do ponto de vista da abordagem, optou-se por realizar uma pesquisa de natureza bibliográfica, fundamentada nos princípios da investigação histórica que se sustenta em uma visão de totalidade, conforme aponta a concepção histórico crítica. Para alcançar a consecução dessas pretensões, apoiou-se em teóricos como: Saviani (2005), Gatti (2006), Carvalho (2005), Nunes (2006), Aranha (1996), Noronha (1998), Tanuri (2000), entre outros que entendem que esta é uma disciplina imprescindível nos cursos de formação de professores. Tendo em vista que coloca em evidência questões indispensáveis à formação docente, ela se aproxima e dialoga com componentes do currículo dos cursos. A sua presença proporciona ao futuro professor uma maior fundamentação para discutir diferentes momentos históricos e a organização educacional em diversos contextos.
SOCIAL AWARENESS ABOUT HYGENIC FOOD FOR MOTHERS & THEIR CHILDREN
Authors: Subarna Taherun Nesa , Masud Nuruddin Ahmed
Published: July 2021

In many low-income developing regions, socioeconomic, climate and demographic, food hygienic factors have been linked to around half of the disease-related deaths that occur each year in the slum area. The purpose of the study is to be aware of hygienic food for mother and their children and find out the government awareness program in the Purba Bania Khamar slums area of the Khulna city of Bangladesh. A community-based survey was carried out in this study. Factors associated with malnutrition, sanitation, water supply, shelter, and food security were assessed using SPSS. The results indicate that the food of mothers and children in a slum place is healthy and safe. Especially healthy foods are recommended from a variety of sources.

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THE GREEK MOVEMENT AGAINST VACCINATION IN GREECE AND THE POTENTIAL SIDE-EFFECTS OF COVID-19 VACCINES
Authors: Vogiatzaki Eirini , Nikolopoulou Anastasia
Published: July 2021

The history of the anti-vaccination movement is long. It does not have a long tradition in Greece. However, from the beginning of COVID-19 and even before a vaccine was discovered, a significant portion of Greeks categorically stated their refusal to participate in vaccination despite the deadly consequences of the virus. This is mainly due to the misinformation they have received and the fact that they believed various conspiracy theories that start with the dangers of vaccines and go as far as the belief that COVID-19 does not exist. These beliefs, in addition to being untrue, also carry a great danger. The more people who refuse to be vaccinated because they think they are doing some kind of resistance, the harder it will be to achieve the collective immunity needed to fight COVID-19. The benefits of vaccination in preventing and protecting against communicable diseases do not only concern the vaccinated population, but, through the immunity of the community, the benefits extend to the whole population, as the transmission of diseases is limited and even people who are not vaccinated are protected such as pregnant women, immunocompromised individuals, and newborns.

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STATUS OF GENDER PARITY IN LABOR MARKET OF NEPAL
Authors: Khadka Gopal
Published: July 2021

The gender parity score is a tool to analyze the real status of women over men in a particular aspect of private and public life. To assess the status of gender parity in the labor market and to explore causes and measures of gender inequality in the labor market situation, this study conducted with the title “Status of gender parity in the labor market of Nepal”. This study is mainly based on the secondary data source of Nepal Labor Force Survey (NLFS-III, 2017/18). Essential Information collected through various search engines by simple literature review. This study revealed that the gender parity is favorable to male in most aspects of the labor market in Nepal. Gender disparity in the labor market is reflection of gender discrimination in Nepalese society. By realizing triple roles of women, i.e. reproductive, productive and community managing activities; it is mandatory to free them from subordination for achieving equality, equity and empowerment. Necessary mechanism should make to fulfill their practical needs and strategic needs. The labor market is the proper area for enhancing status of women. It empowers women more effectively than other mechanism. Gender parity in the labor market ensures overall development of the nation. By giving priority to gender matter, it is essential to conduct intensive, broad-based research investigation to find out the potential impact of ongoing labor policy on gender parity and to introduce evidence-based policies to create opportunities for both male and female without prejudice.

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Estudo comparativo entre Mamografia Espectral Com Contraste e Ressonância Magnética Mamária
Authors: Medinas Luisa
Published: July 2021

Os casos frequentes de diagnóstico de cancro da mama na sociedade atual faz com que o seu diagnóstico precoce seja primordial. A mamografia é o método de eleição para o rastreio da patologia mamária. A Mamografia Espectral com Contraste (CESM-Contrast-enhanced spectral mamografhy) permite que o tumor seja detetado ainda numa fase inicial da doença. Esta nova tecnologia pioneira no Hospital Distrital de Santarém (HDS) é um exame já de rotina nos Estados Unidos da América. O objetivo deste estudo é abordar os benefícios e vantagens do CESM em relação à Ressonância Magnética Mamária (RMM), método utilizado no diagnóstico tradicional, que fornece informações adicionais não obtidas em Mamografia. Através da revisão da literatura avaliámos a qualidade técnica do CESM comparativamente à RMM. Conclui-se neste estudo, que o CESM é uma ferramenta útil no diagnóstico do cancro da mama, com acuidade semelhante à RMM.
Vol. 2, N.º 2, Jul-Dez 2021 - "Uma Profissão, diferentes caminhos"
Authors: Editorial Conselho
Published: July 2021

Terceira publicação da ROENTGEN - Revista Científica das Técnicas Radiológicas, com especial destaque para a temática "Uma Profissão, diferentes caminhos".

Neste número da ROENTGEN pretendemos sensibilizar o leitor para as novas áreas que têm surgido para os profissionais formados na área da Radiologia e de Imagem Médica e Radioterapia, mostrando os caminhos percorridos por alguns pioneiros que os viram como oportunidades e encararam como novos desafios. Tais testemunhos mostram-nos que são caminhos possíveis e de completo sentido para uma profissão de Técnico de Radiologia, à altura de desafiar e acompanhar a transformação tecnológica.
HUBUNGAN KONSENTRASI BELAJAR SISWA TERHADAP PRESTASI BELAJAR PESERTA DIDIK PADA MASA PANDEMI COVID-19 DI SDN KARANG MEKAR 4 BANJARMASIN
Authors: R Riinawati
Published: July 2021

Tujuan penelitian ini yaitu untuk mengetahui ada tidaknya hubungan konsentrasi belajar dengan prestasi belajar peserta didik pada masa pandemi covid-19 di SDN Karang Mekar 4 Banjarmasin. Metode penelitian pada penelitian ini menggunakan deskripsi korelasi. Penelitian ini dilakukan di SDN Karang Mekar 4 Banjarmasin dengan siswa-siswi SDN Karang Mekar 4 Banjarmasin sebagai subjek penelitian. Dalam penelitian ini yang dijadikan objek penelitian adalah Hubungan Konsentrasi Belajar Dengan Prestasi Belajar Peserta Didik pada masa Pandemi Covid-19 Di SDN Karang Mekar 4 Banjarmasin. Populasi dalam penelitian ini adalah siswa siswi SDN Karang Mekar 4 Banjarmasin. Teknik sampel yang digunakan dalam penelitian ini menggunakan purposive sampling dan sampel penelitian ini ditetapkan di kelas III di SDN Karang Mekar 4 Banjarmasin, Kelas III dengan jumlah 32 siswa. Hasil dari penelitian ini menunjukkan bahwa konsentrasi belajar sangat berhubungan erat terhadap prestasi belajar peserta didik pada masa pandemi covid-19 di Sekolah Karang Mekar 4 Banjarmasin, terbukti dengan siswa yang berkonsentrasi belajarnya cukup baik prestasi belajarnyanya lebih baik.
Sudanese Lipid Profile in Diabetics and Non-Diabetics - Central Sudan-2013
Authors:   Assistant professor of Biochemistry, Faculty of Medicine, Department of Biochemistry, Nile Valley University. Atbara, Sudan, Abderahman Nahla Ahmed Mohamed , Ibrahim Mohamed Ahmed ,   Assistant professor of Microbiology, Faculty of Medicine, Department of Microbiology, Nile Valley University. Atbara, Sudan, Adam Nassreldeen Khalid ,   Assistant professor of hematology, Faculty of Medical Laboratory Science, University of Al Fashir, Sudan, Abderahman Marwa Ahmed Mohamed ,   Dermatologist, Ministry of health, Khartoum State, Sudan, Mohamed Ismaeel Abderahman Ahmed ,   Associate professor of Physiology, Faculty of Medicine, Sinnar University, Sinnar State, Sudan
Published: July 2021

Objectives: To find out the association of type 2 diabetes mellitus (T2DM) with increased risk of dyslipidemia and cardiovascular disease in Sudanese population, glucose, lipid profile as well as blood pressure were measured. Materials and Method: A case-control study was made at Gezira State, Sudan, during the period of April 2012-March 2013. A total of two hundred matching inclusion criteria were enrolled in the study, participants divided into diabetic and non-diabetic groups to estimate the levels of FPG, Glycosylated hemoglobin HbA1c and lipid profile (TC, HDL-C, LDL-C, and TG). Samples were analyzed for different biochemical parameters, using A15, a random access auto-analyzer bio system. A questionnaire including personal information was filled as well as anthropometric and biochemical measures. Verbal consent obtain from each respondent then venous blood was collected after an overnight fast. Statistical analysis was carried-out using statistical package for social sciences (SPSS version 16, Chicago, IL, USA). Result: Tukey- HSD test showed that BMI, SBP and DBP increased significantly by (0.001), (0.017) and (0.032) respectively. FPG and HbA1c were increased with highly significant (p=>0.0001). TC, HDL-C and LDL-C showed non-significant increase in their mean concentrations (196.28), (54.28) and (105.75) respectively. TG mean concentration was (158.86) had increased significant (0.057). Conclusion: Study showed significant increase in BMI. Lipid profile of study participants showed no differences in TC and LDL-C and HDL-C, but TG showed significant increased. Systolic (SBP) and diastolic (DBP) blood pressure showed significant increase in all study participants. Study population with T2DM was at high risk to develop metabolic syndrome.
THE IMPACT OF ACCOUNTING INFORMATION SYSTEMS ON UNDERSTANDING BUSINESS PROCESSES
Authors: Barna Laura , Ionescu Bogdan
Published: July 2021

The business environment has evolved over time, so that it has become a dynamic and hyper-competitive environment. The business environment presents many risks. The purpose of the risks is to highlight the success or failure in the business, because some risks are inevitable and some risks can be controlled by companies. For a company to succeed and survive in a dynamic and hyper-competitive business environment, they must find and introduce radical and incremental innovations simultaneously.

Over time, many small, medium and big companies have succeeded in implementing accounting information systems, in order to make their activity more efficient. Investing in accounting systems has a positive impact on the company because they improve the efficiency and effectiveness of the organization, as well as increase the performance. Increasing efficiency and effectiveness means better management and dissemination of information within the company, so that employees have easier access to information and based on them to take the best decisions.

The research method used was quantitative using the questionnaire based on which we identified the main advantages and disadvantages of using accounting information systems, as well as the influence of these systems on the organization and the criteria underlying the choice of these systems. The most relevant results we obtained through our research were: accounting information systems offer both advantages and disadvantages, these systems improve the performance of the organization, and the criteria for choosing these systems depends most on the speed of implementation of the systems.
BOOKING TRAVEL THROUGH THE AIRBNB PLATFORM DURING THE COVID 19 PANDEMIC
Authors: Stiubea Elena
Published: July 2021

The collaborative economy, even if it has moulded well in the tourism market and has developed surprisingly, has been a controversial field from the very beginning, especially as it does not take place within a very well regulated legislative framework. The outbreak of the COVID 19 pandemic severely destabilized all industries, but among the most vulnerable to it was tourism. Not much is known yet about the impact of COVID 19 on traditional sectors, let alone studies or analyses of how the pandemic has affected non-traditional peer-to-peer accommodation. This article attempts a brief analysis of how people have booked or canceled their trips through the Airbnb platform since the beginning of the pandemic. The results show that the sharpest decline was recorded in April 2020 when the number of bookings fell by 72%, compared to the same period in 2019. In the summer months, when most people plan their vacation, the bookings were not numerous, but they kept a certain stability. Compared to June-September 2019, bookings in 2020, during the same period, decreased by 20%. The pandemic has hit this sector hard, especially as all pre-pandemic forecasts showed significant increases in peer-to-peer accommodation between 2020 and 2025 and therefore increases in overall revenue as a result of bookings. This study shows that peer-to-peer accommodation is just as vulnerable to such a pandemic as traditional accommodation. Providers need to rethink their offer in order to reduce financial losses and at the same time protect their employees and provide them with job stability. It can be seen that the cancellations and alterations of the services booked through Airbnb increased exponentially after the outbreak of the COVID 19 pandemic because people could no longer travel from one place to another and even if certain journeys were allowed, people were afraid or felt uncomfortable taking trips.
Digitalization of the Process Landscape for Proprietary Bond Trading
Authors: Petrov Timothy , Neussner Wolfgang , Lackner Maximilian
Published: July 2021

On the surface, the process landscape for fixed income securities trading within most banks has changed only slightly in the past four decades. The value chain remains divided amongst front-, middle-, and back office, with IT in support. Front office negotiates deals with customers and other banks, middle office manages risks and reporting, and back office ensures that payments are made in exchange for a transfer of the bonds that have been traded. Though these processes have gradually migrated to electronic mediums, much of the work in all functional areas remains manual. But the advent of digital technologies, primarily process automation software and data integration in an open software architecture, allows banks to dramatically change how the processes along the value chain are carried out. Repetitive and predictable tasks can be performed by automated software, allowing humans to concentrate on complex activities that require flexibility and discretion. Those tasks that remain in the hands of humans can also be made more efficient by extracting data from software applications along the entire process chain and providing them to the human user at the right point in time in the right system.
AROMATERAPIA E SISTEMA IMUNE - REVISÃO
Authors: Pedroso Reginaldo dos Santos , Pires Regina Helena
Published: July 2021

A utilização de plantas medicinais tem recebido maior atenção nos últimos anos, especialmente pela implantação da Política Nacional de Plantas Medicinais e da Política Nacional de Práticas Integrativas e Complementares. Dentre as últimas, inclui-se a aromaterapia, prática que utiliza o aroma dos óleos essenciais para obtenção de benefícios terapêuticos, como por exemplo obter bem-estar físico e psicológico, auxiliar no tratamento de doenças e morbidades diversas (alergias, câncer, inflamação), e ainda equilibrar as defesas do organismo (efeito imunomodulatório), oferecida pelo SUS desde 2018. Este estudo tem como objetivo revisar as informações sobre a influência da aromaterapia (óleos essenciais) no sistema imune, a fim de compreender melhor esta relação. Para tal realizou-se estudo de revisão narrativa da literatura, buscando-se informações em artigos disponíveis em bases de dados como a Biblioteca Virtual de Saúde (BVS), US National Library of Medicine (PubMed), Scientific Electronic Library Online (Scielo), Scholar Google e Web of Science. A atividade dos óleos essenciais envolve mecanismos não compreendidos, embora alguns possuam potencial efeito na modulação do sistema imune, que são úteis para o tratamento alternativo ou complementar de doenças infecciosas e imunológicas. Evidências apontam que os óleos essenciais podem agir na regulação de citocinas pró-inflamatórias, indução de marcadores anti-inflamatórios, imunoglobulinas e outras vias. Os estudos sobre os efeitos dos óleos essenciais precisam ser intensificados, para sua melhor caracterização e avaliação do potencial tóxico, a fim de se obter uma melhor eficácia e garantia de uso seguro.
TERAPIA OCUPACIONAL TRANSFORMANDO AS EMOÇÕES E OS SENTIMENTOS DE ADOLESCENTES NA REDE PÚBLICA DO MUNICÍPIO DE SÃO GONÇALO
Authors: Silva Santos Thaynan , Silva Noelle Pedroza , Donelate Claudia , Bittencourt Fernandes da Silva Angela Maria
Published: July 2021

Metade dos jovens matriculados na educação pública do Município de São Gonçalo encontram-se na faixa etária de 15 anos a 17 anos, os quais não costumam verbalizar aquilo que sente, mas revelam seus sentimentos e emoções pelo tom de voz, expressão facial/corporal ou por outras formas não verbais. O objetivo do estudo é analisar se a emoção e os sentimentos favorecem a criação de vínculos afetivos, ampliam sua comunicação e interação social. Estudo descritivo/exploratório, com enfoque qualitativo, com base na sociopoética e na Terapia Ocupacional, cujo foco é o corpo, capaz de articular a questão da emoção e do sentimento, buscando interligar subsídios teórico-práticos relativos ao emprego da modalidade expressiva construção, com o intuito de auxiliar aos adolescentes em seu processo natural de desenvolvimento. A análise dos dados se baseou na mudança de comportamento e pela projeção nos lugares sociomíticos. Participaram da pesquisa 33 alunos do ensino médio e fundamental. Eles optaram pelo lugar surreal - falha-caminho-túnel - representativo da emoção e sentimentos. Por meio da atividade de construção surgiram inúmeras opções de descoberta, o que favoreceu o equilíbrio emocional, desenvolveu a expressão, a criatividade e a imaginação possibilitando a descarrega das tensões e a exteriorização das alegrias, temores, desejos e fantasias, pois o ato de construir proporcionou o autoconhecimento, oportunizou o amadurecimento e o reconhecimento de sua identidade. Concluiu-se que se faz necessário ampliar a ação da Terapia Ocupacional com adolescentes para que os mesmos possam externar suas questões emocionais e sociais e desenvolverem seu autoconhecimento.
ZUMBIDO E PROCESSAMENTO AUDITIVO: ESTUDO DA HABILIDADE DE INTEGRAÇÃO AUDITIVA EM INDIVÍDUOS COM QUEIXA DE ZUMBIDO
Authors: Oliveira Lima Daviany , Raquel Diniz da Rosa Marine , Camara Miranda Amanda , Lopes Martins Mariana , Mendonça Maia Wanderley Cruz de Freitas Thaís , Jonatha dos Santos Ferreira Rubens
Published: July 2021

O zumbido caracteriza-se pela presença de um ou mais sons nas orelhas ou na cabeça em ausência de estímulo sonoro externo correspondente. Dentre os sintomas mais comuns que estão associados ao zumbido, a dificuldade na discriminação de fala é um deles. Acredita-se que o zumbido pode apresentar-se como um som competitivo que interfere na integração binaural dos sons. O objetivo deste trabalho foi investigar o desempenho da habilidade auditiva de integração binaural em indivíduos com e sem queixa de zumbido. Tratou-se de um estudo coorte transversal. Participaram 60 voluntários: 30 sem zumbido (grupo controle) e 30 com o sintoma de zumbido (grupo de estudo). Foram excluídos os indivíduos com perdas auditivas. Ambos os grupos foram submetidos à avaliação do processamento auditivo central por meio de dois testes comportamentais:Dicóticos de dissílabos alternados e o teste Dicótico de dígitos. O grupo sem zumbido apresentou melhor desempenho significativo, quando comparado ao grupo com queixa de zumbido em todos os testes e em ambas as orelhas. Não se observou assimetria entre as orelhas, considerando cada grupo separadamente. Além disso, os dois testes dicóticos utilizados apresentaram resultados compatíveis.  Constatou-se que o zumbido pode prejudicar a percepção auditiva, dificultando a integração binaural e atenção seletiva. Sendo assim, é de suma importância a realização de tais testes, visto que esses podem também auxiliar na terapêutica, nas estratégias de uma intervenção eficaz e consequentemente nas habilidades comunicativas.
Traffic Noise Level Assessment in the Residential Area around Different Road Functions in Malang City, East Java, Indonesia
Authors: Tjahjono Ngudi , Hanafi Imam , Latipun Latipun , Suyadi Suyadi
Published: July 2021

Noise due to motorized vehicles is a major problem in urban areas which can interfere with physiological and psychological health. This study aims to determine the extent of noise levels outside and inside the house around the function of different roads in Malang City, East Java, Indonesia. The study was conducted by measuring the traffic noise level using a sound level meter. Measurements were taken in the afternoon between 16.00-21.00 during the peak of heavy traffic and outside working hours when residents were already at home. Statistical Student’s t-test analysis was used to test differences in the average noise level outside and inside the house on each road function. Variance analysis was used to compare noise levels around primary arterial roads, secondary arteries, primary collectors, secondary collectors, primary local, and secondary local. From the measurement results, it is known that the noise due to motorized vehicles is 84.28 dB on average. This exceeds the threshold based on the Decree of the State Minister for the Environment Number 48 of 1996. There was a significant difference in noise level between outside and inside the house on each road function. There was no significant difference in noise level between the functions of the road segments both outside and inside the house. The results of the study concluded that the traffic noise level at 16:00 to 21:00 hours on all roads that were targeted for research exceeds the national threshold. It is recommended that the level of traffic noise around roads in the city of Malang can be reduced to minimize the negative impact on physiological and psychological health.
Effect of Stick - Slip Phenomena between Human Skin and UHMW Polyethylene
Authors: Hussein Emad Kamil , Subhi Kussay Ahmed , Gaaz Tayser Sumer
Published: July 2021

The present paper investigates experimentally effect of applied load and different velocity on the coefficient of friction between two interacting surfaces (human skin and Ultra-high-molecular-weight polyethylene (UHMW- polyethylene) at static and dynamic friction. It is possible to conclude specific point based on the above practical part and frictional analysis of this investigation as the most important mechanical phenomenon was creep has been observed a stick time interval where the static friction force is significantly increased during this stroke. The analytical model for stick-slip of skin and UHMWPE is proposed. The difference between static and kinetic friction defines the amplitude of stick-slip phenomena. The contact pressure, the sliding velocity, and rigidity of system determine the stability conditions of the movement between skin and UHMWPE. Experiments were carried out by developing a device (friction measurement). Variations of friction coefficient during the time at different normal load 4.6 and 9.2 N and low sliding velocity 4, 5, 6 and 7 mm/min were experimentally investigated. The results showed that the friction coefficient varied with the normal load and low sliding velocity. At static friction, the coefficient of friction decreased when the time increases, whereas, at dynamic friction, the coefficient of friction decreased when the time increased at normal load 4.6 and 9.2 N.
Wastewater from Washed Rice Water as Plant Nutrient Source: Current Understanding and Knowledge Gaps
Authors: Abba Nabayi , Sung Christopher Teh Boon , Paing Tan Ngai , Zuan Ali Tan Kee
Published: July 2021

A significant wastewater source in every household is washed rice water (WRW) because it contains leached nutrients (from washing the rice prior to cooking) that could be used as fertilizer. The paper reviewed the current understanding of the potential use of WRW as a plant nutrient source. WRW was shown to increase vegetables growth, such as water spinach, pak choy, lettuce, mustard, tomato, and eggplant. Different researchers have used various amounts of WRW, and their results followed a similar trend: the higher the amount of WRW, the higher the plant growth. WRW has also been used for other purposes, such as a source of carbon for microbial growth. WRW from brown rice and white rice had nutrients ranging from 40-150, 43-16306, 51-200, 8-3574, 36-1425, 27-212, and 32-560 mg L-1 of N, P, K, Ca, Mg, S, and vitamin B1 (thiamine), respectively. Proper utilization of WRW could reduce chemical fertilizer use and prevent both surface and groundwater contamination and environmental pollution. However, only a few of the studies have compared the use of WRW with the use of conventional NPK fertilizer. The major drawback of WRW studies is that they lack depth and scope, such as determining the initial and (or) final soil physico-chemical properties or plant nutrient contents. Considering the rich nutrient content in WRW, it will impact plant growth and soil fertility when used as both irrigation water and plant nutrient source. Therefore, it is recommended that studies on WRW effect on soil microbial population, plant, and soil nutrient contents to be carried out to ascertain the sustainability of WRW use as a plant nutrient source.