bluuebunny/crossref_metadata_2025 huggingface dataset:
Typological Similarity between Languages Modulates the Neural Mechanisms of Selective Attention in Bilinguals
Authors: Wang Jingkang , Olguin Andrea , Bozic Mirjana
Published: November 2023

Bilingualism has been shown to modulate neural mechanisms of auditory selective attention, due to the constant need to select the target language and inhibit the unwanted ones. To investigate the impact of typological similarity between bilinguals’ languages on attentional modulation, this study investigated the neural adaptation of selective attention in early bilinguals speaking very dissimilar languages (Chinese-English), and compared their results to existing data for English monolinguals, and bilinguals speaking more similar languages (early Spanish-English and Dutch-English bilinguals, Olguin et al., 2018; 2019). Using the same dichotic listening design, Chinese-English bilinguals (proficient in L2 English) attended to a narrative in Mandarin Chinese (native language) in one ear, while simultaneously ignoring a competing distractor in the other ear. The type / intelligibility of unattended distractors (Chinese narratives, Serbian narratives （unknown language）, non-linguistic stream or no interference) were manipulated to generate four conditions. EEG activities were cross-correlated with speech envelopes of corresponding attended and unattended streams. Results from Chinese-English bilinguals showed stronger neural encoding of attended than unattended streams in all conditions, and attentional encoding varied as the distractor changed from non-linguistic to linguistic (narratives) but did not differ between conditions of linguistic interference - a pattern half-way between monolinguals and typologically-similar bilinguals. Results of Representational Similarity Analysis indicated that of all bilingual groups, the overall patterns of neural encoding in Chinese-English bilinguals were the closest to those of monolinguals over time, suggesting higher L1-L2 dissimilarity leads to less modulation of selective attention mechanisms and a more monolingual-like pattern of neural encoding.
EFL STUDENTS’ PREFERENCES OF A GOOD ENGLISH TEACHERS
Authors: Setiadi Muhammad Ikhsan , Febriyanti Emma Rosana
Published: November 2023

The process of teaching is a continuous learning journey, even with years of experience in teaching English as a foreign language, it is difficult to determine how to be an effective teacher. Different learners and teachers have also different views on what constitutes a "good English language teacher”. The aims of this study are to investigate and identify the qualities and characteristics that make an English teacher competent, as perceived by learners, particularly in the post COVID-19 and to gain insights into how learners' preferences may have evolved or changed due to the challenges and experiences faced during the pandemic, and how these factors influence their evaluation of effective English teachers. The participants in this study are students enrolled in the English Department of FKIP Lambung Mangkurat University Banjarmasin, spanning one batch which is 2020 with total 49 respondent students as participants. Data was collected at the sixth semester using a quantitative descriptive method this was employed to assess the students' feedback using a survey tool adapted from research conducted by Wichadee (2010) and Zamani and Angahari (2016). The questionnaire using close-ended question based on a four-point Likert scale. Total there are 60 statements and it divides from 4 categories (Socio-affective, Pedagogical Knowledge, Proficiency Skills Organization and Communication Skills) and there are 15 statements for each category. Based on the result, the most considered as prominent from the other category is Organization and Communication Skills, as many 82% respondents agreed that teacher should have good competencies especially in good communication skills. The anticipated findings of this study can assist teachers in self-reflection, evaluation, and the enhancement of their teaching practices. Additionally, it can contribute to their personal growth.
Dynamic stiffness identification methods: experimental study and validation
Authors: Slimane Rabii , El Khatiri Wafaa , Cherif Raef , Atalla Noureddine
Published: November 2023

In a vehicle, the operation of mechanical systems generates undesirable vibrations and noise, and their reduction requires the study of three parts: vibrating systems, receiving structures, and connecting interfaces. The study presented in this paper concerns the connecting interfaces between subsystems. In particular, the in situ characterization of the isolation interface between two substructures by measuring dynamic transfer stiffness. In contrast to current methods, which require the disassembly of the vibration isolator from its original assembly, in situ methods have been studied and validated. This study sheds light on the strengths and limitations of each approach. These are known as the direct in situ method (D-IS) and round trip in situ method (RT-IS). Experimental validation has been carried out by comparing the D-IS method to the resonance method on a simple system. Good agreement is obtained between the two methods, making it possible to validate the method at low frequencies. Then, a comparison between the two methods D-IS and RT-IS is carried out on a more resonant test bench. The obtained stiffnesses were further validated using transfer path analysis (TPA) techniques to verify the performance of the proposed methods, and it was used to predict the response of another system, showing thus the independent nature of the identified dynamic stiffness.
Structural tuning of β-enamino diketones: exploration of solution and crystalline state photochromism
Authors: Manjappa Kiran B. , Fan Sheng-Chieh , Yang Ding-Yah
Published: November 2023

A library of β-enamino diketones was prepared via base-mediated, three-component reaction of 4-hydroxycoumarins with various aromatic/aliphatic amines and β-nitrostyrenes under microwave irradiation conditions to investigate their photochemical properties. Among the prepared compounds, a thiophene derived β-enamino diketone was found to be light-sensitive and to exhibit unique photochromic behavior, that is, positive photochromism in solution and negative photochromism in crystalline phase. In addition, this prepared photochromic compound was further covalently linked to a structure-related, piezochromic β-enamino diketone moiety to explore its potential multi-stimuli responsive properties.
Serum uric acid levels and risk of cardiovascular disease in type 2 diabetes: results from a cross-sectional study and Mendelian randomization analysis
Authors: He Ying , Feng Jincheng , Zhang Bo , Wu Qiong , Zhou Yongjie , He Diao , Zheng Daofeng , Yang Jiayin
Published: November 2023

Aims

Serum uric acid (SUA) levels have been previously linked to a higher risk of cardiovascular disease (CVD) in individuals with type 2 diabetes (T2D) according to various observational studies. However, whether this association is causally linked or simply influenced by confounding factors is unclear. Therefore, this study utilized Mendelian randomization (MR) analysis to explore the causality between SUA levels and the risk of CVD in individuals with T2D.

Methods

Our study cohort consisted of 5723 participants who were diagnosed with T2D in the National Health and Nutrition Examination Survey (NHANES) from 1999-2018. The study assessed the association between SUA levels and the risk of CVD using a multivariable logistic regression model. To further examine causality between SUA levels and CVD, a two-sample MR study was conducted utilizing genetic data from genome-wide association studies (GWAS) involving over 140,000 individuals. The main MR analysis employed the inverse-variance-weighted (IVW) method. Additionally, several sensitivity analyses were performed to evaluate the robustness and pleiotropy of the results.

Results

In the cross-sectional study, after multivariable adjustment, participants with SUA levels >6.7 mg/dL exhibited odds ratios (ORs) of 1.51 (95% CI: 1.01-2.26, p=0.049) for heart failure, 1.02 (95% CI: 0.69-1.50, p=0.937) for coronary heart disease, 1.36 (95% CI: 0.78-2.38, p=0.285) for angina, and 1.22 (95% CI: 0.80-1.85, p=0.355) for myocardial infarction when compared to participants with SUA levels ≤ 4.6 mg/dL. However, in the IVW analysis, no causality between SUA levels and the risk of heart failure was observed (OR = 1.03, 95% CI: 0.97-1.09, p = 0.293). The secondary analysis yielded similar results (OR = 1.05, 95% CI: 0.96-1.14, p = 0.299). The sensitivity analyses further supported our primary findings.

Conclusion

Based on the MR study, we did not find supporting evidence for a causal association between SUA levels and the risk of heart failure.
Iodine-to-calcium ratios in deep-sea scleractinian and bamboo corals
Authors: Sun Yun-Ju , Robinson Laura F. , Parkinson Ian J. , Stewart Joseph A. , Lu Wanyi , Hardisty Dalton S. , Liu Qian , Kershaw James , LaVigne Michèle , Horner Tristan J.
Published: November 2023

The distribution of dissolved iodine in seawater is sensitive to multiple biogeochemical cycles, including those of nitrogen and oxygen. The iodine-to-calcium ratio (I/Ca) of marine carbonates, such as bulk carbonate or foraminifera, has emerged as a potential proxy for changes in past seawater oxygenation. However, the utility of the I/Ca proxy in deep-sea corals, natural archives of seawater chemistry with wide spatial coverage and radiometric dating potential, remains unexplored. Here, we present the first I/Ca data obtained from modern deep-sea corals, specifically scleractinian and bamboo corals, collected from the Atlantic, Eastern Pacific, and Southern Oceans, encompassing a wide range of seawater oxygen concentrations (10–280 μmol/kg). In contrast to thermodynamic predictions, we observe higher I/Ca ratios in aragonitic corals (scleractinian) compared to calcitic corals (bamboo). This observation suggests a strong biological control during iodate incorporation into deep-sea coral skeletons. For the majority of scleractinian corals, I/Ca exhibits a covariation with local seawater iodate concentrations, which is closely related to seawater oxygen content. Scleractinian corals also exhibit notably lower I/Ca below a seawater oxygen threshold of approximately 160 μmol/kg. In contrast, no significant differences in I/Ca are found among bamboo corals across the range of oxygen concentrations encountered (15–240 μmol/kg). In the North Atlantic, several hydrographic factors, such as temperature and/or salinity, may additionally affect coral I/Ca. Our results highlight the potential of I/Ca ratios in deep-sea scleractinian corals to serve as an indicator of past seawater iodate concentrations, providing valuable insights into historical seawater oxygen levels.
Acute coronary syndrome associated cardiogenic shock in the catheterization laboratory: peripheral veno-arterial extracorporeal membrane oxygenator management and recommendations
Authors: Ehrenberger Réka , Németh Balázs T. , Kulyassa Péter , Fülöp Gábor A. , Becker Dávid , Kiss Boldizsár , Zima Endre , Merkely Béla , Édes István F.
Published: November 2023

Cardiogenic shock (CS) in acute coronary syndrome (ACS) is a critical disease with high mortality rates requiring complex treatment to maximize patient survival chances. Emergent coronary revascularization along with circulatory support are keys to saving lives. Mechanical circulatory support may be instigated in severe, yet still reversible instances. Of these, the peripheral veno-arterial extracorporeal membrane oxygenator (pVA-ECMO) is the most widely used system for both circulatory and respiratory support. The aim of our work is to provide a review of our current understanding of the pVA-ECMO when used in the catheterization laboratory in a CS ACS setting. We detail the workings of a Shock Team: pVA-ECMO specifics, circumstances, and timing of implantations and discuss possible complications. We place emphasis on how to select the appropriate patients for potential pVA-ECMO support and what characteristics and parameters need to be assessed. A detailed, stepwise implantation algorithm indicating crucial steps is also featured for practitioners in the catheter laboratory. To provide an overall aspect of pVA-ECMO use in CS ACS we further gave pointers including relevant human resource, infrastructure, and consumables management to build an effective Shock Team to treat CS ACS via the pVA-ECMO method.
Detailed findings of videofluoroscopic examination among patients with Parkinson's disease on the effect of cervical percutaneous interferential current stimulation
Authors: Nakamori Masahiro , Toko Megumi , Yamada Hidetada , Hayashi Yuki , Haruta Azusa , Hiraoka Aya , Yoshikawa Mineka , Nagasaki Toshikazu , Ushio Kai , Yoshikawa Kohei , Shimizu Yoshitaka , Mikami Yukio , Maruyama Hirofumi
Published: November 2023

Introduction

Parkinson's disease (PD) leads to various types of swallowing disorders. We investigated the effect of cervical percutaneous interferential current stimulation on dysphagia. By conducting detailed qualitative and quantitative analysis of videofluoroscopic examination, we aimed to understand dysphagia in patients with PD and investigate its effects on swallowing function.

Methods

Patients received cervical percutaneous interferential current stimulation for 20 min twice a week for 8 weeks. In this exploratory study, we evaluated aspiration/laryngeal penetration, oral cavity residue, vallecular residue, and pharyngeal residue. In addition, we performed temporal analysis.

Results

Twenty-five patients were completely evaluated. At baseline, the proportions of laryngeal penetration/aspiration, oral cavity residue, epiglottic vallecula residue, and pharyngeal residue were 40.0, 88.0, 72.0, 60.0, and 16.0%, respectively. Conversely, pharyngeal transit time, laryngeal elevation delay time, pharyngeal delay time, and swallowing reflex delay were nearly within the normal ranges. Cervical percutaneous interferential current sensory stimulation improved only oral cavity residue at the end of the intervention, from 88.0 to 56.0%.

Discussion

Patients with PD demonstrated remarkably high frequencies of residues in the oral and pharyngeal regions. The usefulness of cervical interferential current stimulation was partially demonstrated for oral cavity residue. Considering that PD exhibits diverse symptoms, further accumulation of cases and knowledge is warranted.

Trial registration

jRCTs062220013.
Enteroendocrine cell regulation of the gut-brain axis
Authors: Barton Joshua R. , Londregan Annie K. , Alexander Tyler D. , Entezari Ariana A. , Covarrubias Manuel , Waldman Scott A.
Published: November 2023

Enteroendocrine cells (EECs) are an essential interface between the gut and brain that communicate signals about nutrients, pain, and even information from our microbiome. EECs are hormone-producing cells expressed throughout the gastrointestinal epithelium and have been leveraged by pharmaceuticals like semaglutide (Ozempic, Wegovy), terzepatide (Mounjaro), and retatrutide (Phase 2) for diabetes and weight control, and linaclotide (Linzess) to treat irritable bowel syndrome (IBS) and visceral pain. This review focuses on role of intestinal EECs to communicate signals from the gut lumen to the brain. Canonically, EECs communicate information about the intestinal environment through a variety of hormones, dividing EECs into separate classes based on the hormone each cell type secretes. Recent studies have revealed more diverse hormone profiles and communication modalities for EECs including direct synaptic communication with peripheral neurons. EECs known as neuropod cells rapidly relay signals from gut to brain via a direct communication with vagal and primary sensory neurons. Further, this review discusses the complex information processing machinery within EECs, including receptors that transduce intraluminal signals and the ion channel complement that govern initiation and propagation of these signals. Deeper understanding of EEC physiology is necessary to safely treat devastating and pervasive conditions like irritable bowel syndrome and obesity.
MiR-124-3p mediates gastric cancer cell ferroptosis induced by an anti-cancer drug polyphyllin I
Authors: Zheng Fang , Bi Jian-Can , Wei Yu-Yan , Wang Yeshu , Zhang Qunfang , Liang Chun-Ling , Wu Jianwei , Dai Zhenhua
Published: November 2023

Background: Ferroptosis is an emerging type of regulated cell death and associated with antitumoral therapy, while some microRNAs have been shown to regulate the tumorigenesis and cancer progression. Meanwhile, polyphyllin I (PPI) has exhibited antitumoral effects by promoting cancer cell apoptosis and ferroptosis. However, it is unclear whether PPI induces cancer cell ferroptosis by regulating microRNAs.

Methods: We used two gastric cancer cell lines (AGS and MKN-45) to set up a tumor model of the nude mice, which were then treated daily with PPI to measure the cancer growth in vitro and in vivo. Ferroptosis was measured using immunofluorescence staining and flow cytometric analysis according to levels of intracellular ROS, lipid ROS and ferrous ions. Moreover, NRF2 expression was measured by Western blotting. In some experiments, the mimics or inhibitors of miR-124-3p were used to further confirm its involvement in PPI-induced cancer cell ferroptosis.

Results: Here we found that miR-124-3p mediated cancer ferroptosis and tumor repression induced by PPI since PPI increased miR-124-3p expression in gastric cancer cells and promoted their ferroptosis, whereas inhibition of miR-124-3p mostly abolished the effects of PPI on tumor growth, ferroptosis and NRF2 expression. Moreover, miR-124-3p mimics promoted cancer cell ferroptosis by downregulating NRF2 through directly targeting 3′-UTR region of NRF2, confirming a role for miR-124-3p in regulating PPI-induced ferroptosis.

Conclusion: PPI exerts its antitumoral effects on the gastric cancer by promoting cell ferroptosis via regulating miR-124-3p. Our findings have clinical implications for cancer chemotherapy.
Correlates of intimate relationship satisfaction among investigators of child sexual abuse material
Authors: Gewirtz-Meydan Ateret , O'Brien Jennifer E. , Mitchell Kimberly J.
Published: November 2023

Introduction

This study investigates correlates of intimate relationship satisfaction among investigators of child sexual abuse material (CSAM). Previous research has shown that exposure to CSAM content can negatively impact investigators’ emotional wellbeing, but little is known about its association with their intimate relationships.

Methods

The study included 500 participants who were police investigators, forensic examiners, and other professionals connected with the criminal justice system in the United States that are exposed to CSAM as part of their profession. The study collected data through an anonymous survey administered via the Qualtrics online survey system.

Results

The findings reveal that higher levels of depressive symptoms and post-traumatic stress disorder are associated with lower relationship satisfaction among CSAM investigators. Additionally, group connectedness is positively related to relationship satisfaction for both men and women. Parent investigators also reported lower relationship satisfaction, suggesting unique challenges faced by this subgroup. Exposure to varying types of CSAM content was not significantly related to lower relationship satisfaction. This study highlights the association between depressive symptoms and PTSD with relationship satisfaction among CSAM investigators, emphasizing the role of group connectedness in promoting positive outcomes for both male and female investigators.

Discussion

Recognizing the association between depressive symptoms and PTSD with relationship satisfaction can guide interventions and support services for investigators, promoting group connectedness and addressing mental health concerns to enhance resilience and effectiveness in combating child exploitation.
Machine learning-based classification analysis of knowledge worker mental stress
Authors: Kim Hyunsuk , Kim Minjung , Park Kyounghyun , Kim Jungsook , Yoon Daesub , Kim Woojin , Park Cheong Hee
Published: November 2023

The aim of this study is to analyze the performance of classifying stress and non-stress by measuring biosignal data using a wearable watch without interfering with work activities at work. An experiment is designed where participants wear a Galaxy Watch3 to measure HR and photoplethysmography data while performing stress-inducing and relaxation tasks. The classification model was constructed using k-NN, SVM, DT, LR, RF, and MLP classifiers. The performance of each classifier was evaluated using LOSO-CV as a verification method. When the top 9 features, including the average and minimum value of HR, average of NNI, SDNN, vLF, HF, LF, LF/HF ratio, and total power, were used in the classification model, it showed the best performance with an accuracy of 0.817 and an F1 score of 0.801. This study also finds that it is necessary to measure physiological data for more than 2 or 3 min to accurately distinguish stress states.
Decamethoxin and chlorhexidine bigluconate effect on the adhesive and biofilm-forming properties of Streptococcus mitis
Authors: Faustova Mariia O. , Chumak Yuliia V. , Loban’ Galina A. , Ananieva Maiia M. , Havryliev Viktor M.
Published: November 2023

The aim of the study

Was to investigate the effect of antiseptics on the adhesive and biofilm-forming properties of clinical S.mitis isolates isolated from the oral cavity of patients with an infectious and inflammatory post-extraction complication.

Materials and methods

Twenty four clinical isolates of S.mitis isolated from patients were studied. The studied antiseptics included 0.02% aqueous solution of decamethoxin and 0.05% solution of chlorhexidine bigluconate. Adhesion of clinical isolates under the action of decamethoxin and chlorhexidine bigluconate was determined by the method of V.I. Brillis. The biofilm-forming properties of clinical isolates were studied using the “microtiter plate test” according to G.D. Christensen.

Results

The studied clinical isolates of S.mitis are classified as highly adherent microorganisms. Action of decamethoxin on clinical isolates decreases the adhesion index of the studied isolates in comparison with the adhesion index of the control culture. Action of chlorhexidine bigluconate on S.mitis isolates increases of adhession of the studied clinical isolates in comparison with the control. After the effect of decamethoxin, the optical density of clinical isolates decreased considering the optical density results of the control. The clinical isolates left an average film-forming capacity even after chlorhexidine bigluconate action.

Conclusions

Clinical isolates of S.mitis are highly adherent microorganisms. The antiseptic decamethoxin decreases the adhesion index of these bacteria, while chlorhexidine bigluconate increases the adhesion index of clinical S.mitis isolates. Clinical S. mitis isolates have an average biofilm formation capacity index. The antiseptic decamethoxin inhibits the biofilm formation capacity of S.mitis from medium to low.
Western Hemisphere quality and production capacity of soybean protein
Authors: Cerrudo Anibal , Miller-Garvin Jill , Naeve Seth L.
Published: November 2023

Soybean’s protein concentration and amino acid profile vary geographically due to genotype and environment. We used 1817 on-farm grain samples from the United States, Brazil, and the Southern Cone to assess soybean protein variability in the Western Hemisphere, which accounts for 85% of global production. Our analysis found consistent spatial patterns for protein concentration and amino acid composition, with differences in protein concentration of up to 5.4% among regions. While there was a negative correlation between protein concentration and the abundance of critical amino acids (lysine, cysteine, threonine, methionine, and tryptophane), their amount per ton of grain increased with protein concentration. Our findings can guide market and industry in benchmarking soybean protein quality across the Western Hemisphere, which according to our projection could supply close to 120 million metric tons of protein and 17 million metric tons of the most critical amino acids annually by 2030.
Kinetics of foot-and-mouth disease vaccine-induced antibody responses in buffaloes (Bubalus bubalis): avidity ELISA as an alternative to the virus neutralization test
Authors: Sala Juan Manuel , Mansilla Florencia Celeste , Miraglia María Cruz , Caspe Sergio Gastón , Perez-Filgueira Daniel Mariano , Capozzo Alejandra Victoria
Published: November 2023

The role of water buffaloes in foot-and-mouth disease (FMD) epidemiology as one of the major hosts of the virus that can develop persistent asymptomatic infection highlights the importance of sustaining surveillance on the antibody response elicited by vaccination in these animals. There is gap in the knowledge on how serological assays that measure antibodies against capsid proteins perform with buffalo samples and which would be the most reliable test to substitute the virus neutralization test (VNT) a cumbersome and low-throughput tool for field surveillance. Alternatively, the liquid-phase blocking sandwich ELISA (LPBE) is commonly used. Previous data from our laboratory demonstrated that the vaccine-induced antibodies assessed by the LPBE yielded low specificity with buffaloes’ samples. In contrast, a single-dilution avidity ELISA (AE) aimed to detect high-avidity antibodies against exposed epitopes, combined with an indirect ELISA (IE) to assess IgG levels, produced more reliable results. Here we analyzed for the first time the kinetics of the antibodies induced by vaccination in two different buffalo herds (n = 91) over 120 days using AE, IE, LPBE, and the VNT. Kinetics were similar in the different assays, with an increase of antibodies between 0- and 14-days post-vaccination (dpv) which were maintained thereafter. VNT and AE results were concordant (Kappa value = 0.76), and both assays revealed a decay in the antibody response in calves with maternal antibodies at 90 and 120 dpv, which was not evidenced by the LPBE. These results show that kinetics of antibody responses to FMD vaccination are similar in buffalo and cattle, and support the use of indirect ELISA assays, in particular Avidity ELISA, as alternatives to the VNT for vaccine-immunity monitoring irrespectively of the animal’s passive or active immune status.
A Decade of Experience With Alemtuzumab Therapy for Severe or Glucocorticoid-Resistant Kidney Transplant Rejection
Authors: van Vugt Lukas K. , van der Zwan Marieke , Clahsen-van Groningen Marian C. , van Agteren Madelon , Hullegie-Peelen Daphne M. , De Winter Brenda C. M. , Reinders Marlies E. J. , Miranda Afonso Pedro , Hesselink Dennis A.
Published: November 2023

Alemtuzumab is used as lymphocyte-depleting therapy for severe or glucocorticoid-resistant kidney transplant rejection. However, the long-term efficacy and toxicity of alemtuzumab therapy are unclear. Therefore, all cases of alemtuzumab anti-rejection therapy between 2012 and 2022 in our institution were investigated. Graft survival, graft function, lymphocyte depletion, serious infections, malignancies, and patient survival were analyzed and compared with a reference cohort of transplanted patients who did not require alemtuzumab anti-rejection therapy. A total of 225 patients treated with alemtuzumab were identified and compared with a reference cohort of 1,668 patients. Over 60% of grafts was salvaged with alemtuzumab therapy, but graft survival was significantly poorer compared to the reference cohort. The median time of profound T- and B lymphocyte depletion was 272 and 344 days, respectively. Serious infection rate after alemtuzumab therapy was 54.1/100 person-years. The risk of death (hazard ratio 1.75, 95%-CI 1.28–2.39) and infection-related death (hazard ratio 2.36, 95%-CI 1.35–4.11) were higher in the alemtuzumab-treated cohort. In conclusion, alemtuzumab is an effective treatment for severe kidney transplant rejection, but causes long-lasting lymphocyte depletion and is associated with frequent infections and worse patient survival outcomes.
The Behavioral Adaptations and Barriers of Patients Employing Non-Pharmacological Strategies for Cancer Pain Management—A Qualitative Study
Authors: Liu Man-Ting , Liang Shu-Yuan , Chao Ta-Chung , Tseng Ling-Ming , Rosenberg John
Published: November 2023

The use of non-pharmacological strategies to complement pharmacological approaches can enhance cancer pain management by promoting patient autonomy and increasing management effectiveness. This study aimed to explore the required behavioral adaptations and situational barriers that cancer patients encounter when utilizing non-pharmacological strategies to manage pain. We adopted an exploratory–descriptive qualitative research approach, purposive sampling, and semi-structured interview guidelines to conduct face-to-face interviews with 18 cancer patients experiencing moderate or severe levels of worst pain. Data were analyzed using inductive content analysis to explore patients’ experiences. Five themes described the behavioral adaptations of patients using non-pharmacological strategies to deal with cancer pain: finding complementary therapies, utilizing assistive skills, adapting to assistive skills, diverting attention, and seeking help. Situational barriers faced by patients include being in the workplace or in a climate-affected environment. Behavioral adaptation is necessary for non-pharmacological strategies to coping with cancer pain. The behavioral skills can help the patients to overcome situational barriers to engagement with these strategies. Thus, health professionals are expected to help the patients acquire adequate behavioral adaptation and skills for self-pain management, and assess the effectiveness of the strategies.
The Management of Chronic Pain: Re-Centring Person-Centred Care
Authors: Themelis Kristy , Tang Nicole K. Y.
Published: November 2023

The drive for a more person-centred approach in the broader field of clinical medicine is also gaining traction in chronic pain treatment. Despite current advances, a further departure from ‘business as usual’ is required to ensure that the care offered or received is not only effective but also considers personal values, goals, abilities, and day-to-day realities. Existing work typically focuses on explaining pain symptoms and the development of standardised interventions, at the risk of overlooking the broader consequences of pain in individuals’ lives and individual differences in pain responses. This review underscores the importance of considering additional factors, such as the influence of chronic pain on an individual’s sense of self. It explores innovative approaches to chronic pain management that have the potential to optimise effectiveness and offer person-centred care. Furthermore, it delves into research applying hybrid and individual formulations, along with self-monitoring technologies, to enhance pain assessment and the tailoring of management strategies. In conclusion, this review advocates for chronic pain management approaches that align with an individual’s priorities and realities while fostering their active involvement in self-monitoring and self-management.
Thermographic Changes following Short-Term High-Intensity Anaerobic Exercise
Authors: Fink Nir , Bogomilsky Shai , Raz Avi , Hoffer Oshrit , Scheinowitz Mickey
Published: November 2023

Current studies report thermographic changes following aerobic or resistance exercise but not short, vigorous anaerobic exercise. Therefore, we investigated body surface temperature changes using thermal imaging following a short session of anaerobic exercise. We studied three different regions of interest (ROIs): the legs, chest, and forehead. Thermal imaging for each participant was performed before and immediately after completing a Wingate anaerobic test and every minute during a 15 min recovery period. Immediately after the test, the maximum temperature was significantly higher in all ROIs (legs, p = 0.0323; chest, p = 0.0455; forehead, p = 0.0444) compared to pre-test values. During the recovery period, both legs showed a significant and continuous temperature increase (right leg, p = 0.0272; left leg, p = 0.0382), whereas a non-significant drop was noted in the chest and forehead temperatures. Additionally, participants with a lower anaerobic capacity exhibited a higher delta increase in surface leg temperature than participants with higher anaerobic capacities, with a minimal change in surface leg temperature. This is the first study to demonstrate body surface temperature changes following the Wingate anaerobic test. This temperature increase is attributed to the high anaerobic mechanical power outputs achieved by the leg muscles and the time taken for temperature reduction post-exercise.
Cloning, Expression, Purification, and Characterization of a Novel β-Galactosidase/α-L-Arabinopyranosidase from Paenibacillus polymyxa KF-1
Authors: Cui Jing , Wang Yibing , Zhou Andong , He Shuhui , Mao Zihan , Cao Ting , Wang Nan , Yuan Ye
Published: November 2023

Glycosidases are essential for the industrial production of functional oligosaccharides and many biotech applications. A novel β-galactosidase/α-L-arabinopyranosidase (PpBGal42A) of the glycoside hydrolase family 42 (GH42) from Paenibacillus polymyxa KF-1 was identified and functionally characterized. Using pNPG as a substrate, the recombinant PpBGal42A (77.16 kD) was shown to have an optimal temperature and pH of 30 °C and 6.0. Using pNPαArap as a substrate, the optimal temperature and pH were 40 °C and 7.0. PpBGal42A has good temperature and pH stability. Furthermore, Na+, K+, Li+, and Ca2+ (5 mmol/L) enhanced the enzymatic activity, whereas Mn2+, Cu2+, Zn2+, and Hg2+ significantly reduced the enzymatic activity. PpBGal42A hydrolyzed pNP-β-D-galactoside and pNP-α-L-arabinopyranoside. PpBGal42A liberated galactose from β-1,3/4/6-galactobiose and galactan. PpBGal42A hydrolyzed arabinopyranose at C20 of ginsenoside Rb2, but could not cleave arabinofuranose at C20 of ginsenoside Rc. Meanwhile, the molecular docking results revealed that PpBGal42A efficiently recognized and catalyzed lactose. PpBGal42A hydrolyzes lactose to galactose and glucose. PpBGal42A exhibits significant degradative activity towards citrus pectin when combined with pectinase. Our findings suggest that PpBGal42A is a novel bifunctional enzyme that is active as a β-galactosidase and α-L-arabinopyranosidase. This study expands on the diversity of bifunctional enzymes and provides a potentially effective tool for the food industry.
Hydrodeoxygenation of Oxygenates Derived from Biomass Pyrolysis Using Titanium Dioxide-Supported Cobalt Catalysts
Authors: Hongkailers Surachet , Pattiya Adisak , Hinchiranan Napida
Published: November 2023

Bio-oil upgrading to produce biofuels and chemicals has become an attractive topic over the past decade. However, the design of cost- and performance-effective catalysts for commercial-scale production remains a challenge. Herein, commercial titania (TiO2) was used as the support of cobalt (Co)-based catalysts (Co/TiO2) due to its low cost, high availability, and practicability for commercialization in the future. The Co/TiO2 catalysts were made with two different forms of TiO2 (anatase [TiO2–A] and rutile [TiO2–R]) and comparatively evaluated in the hydrodeoxygenation (HDO) of 4-propylguaicol (4PG), a lignin-derived model compound. Both Co/TiO2 catalysts promoted the HDO of 4PG following a similar pathway, but the Co/TiO2–R catalyst exhibited a higher activity in the early stages of the reaction due to the formation of abundant Ti3+ species, as detected by X-ray photoelectron spectroscopy (XPS) and hydrogen–temperature programed reduction (H2–TPR) analyses. On the other hand, the Co/TiO2–A catalyst possessed a higher acidity that enhanced propylcyclohexane production at prolonged reaction times. In terms of reusability, the Co/TiO2–A catalyst showed a higher stability (less Co leaching) and reusability compared to Co/TiO2–R, as confirmed by transmission electron microscopy (TEM) and inductively coupled plasma optical emission spectroscopy (ICP-OES) analyses. The HDO of the real bio-oil derived from pyrolysis of Leucaena leucocephala revealed that the Co/TiO2–A catalyst could convert high oxygenated aromatics (methoxyphenols, dimethoxyphenols, and benzenediols) to phenols and enhanced the phenols content, hinting at its potential to produce green chemicals from bio-feedstock.
Evaluación formativa y desarrollo de competencias en el proceso educativo: Una revisión sistemática
Authors: Huauya Huamaní Lupe Esthefany , Vacas-Gonzales Francisco Antonio , Solis Trujillo Beymar Pedro
Published: November 2023

La evaluación basada en el desarrollo de competencias es una prioridad actual para las instituciones educativas. Por lo tanto, se asume que la evaluación formativa (EF) se utiliza para aprender y adquirir las competencias necesarias para un correcto desenvolvimiento en la sociedad actual. El objetivo de este trabajo fue describir el impacto de la evaluación formativa en el desarrollo de competencias en el proceso educativo a través de una revisión sistemática de fuentes secundarias en diferentes niveles educativos. La búsqueda se hizo en las bases de datos Scopus, Ebsco, Scielo y Mendeley de Elsevier. La revisión de la literatura emplea los métodos de análisis-síntesis e inductivo-deductivo y se guía por la interpretación de la literatura científica. En conclusión, la evaluación formativa en el proceso educativo es una estrategia del sistema de evaluación enfocada a desarrollar aprendizajes significativos, autónomos y funcionales mediante un acompañamiento permanente.
GAMBARAN PENGETAHUAN DAN SIKAP REMAJA TENTANG ROKOK DAN BAHAYANYA
Authors: Jauhara Siti Hasna , Sunandar Kuslan , Washudi Washudi , Rumijati Tjutju
Published: November 2023

Based on Riskesdas 2007 by 34.2%, Riskesdas 2010 by 34.3% and Riskesdas 2013 to 36.3%. The purpose of this study was to determine the Knowledge and Adolescent Attitudes About Cigarettes and the Dangers in SMP Negeri 9 Bandung. The design of this research is descriptive. The population in this study were adolescents grade VII and VIII of SMP Negeri 9 Bandung. The sampling technique uses stratified random sampling method with a sample of 246 respondents. The instrument used in this study was a questionnaire to find out the knowledge and attitudes of adolescents about smoking and its dangers. Based on the results of research on Adolescent Knowledge about Cigarettes and the Dangers in SMP Negeri 9 Bandung 2020 almost half of the respondents were in the sufficient category of 94 people (38.2%). And the Description of Adolescent Attitudes About Cigarettes and the Dangers in SMP Negeri 9 Bandung 2020, more than half of the respondents were in the category of quite supportive attitudes namely 164 people (66.7%). It is recommended for educational institutions of SMP Negeri 9 Bandung to be able to provide information about cigarettes and the dangers, especially regarding the content of cigarettes and attitudes influenced by friendship / friendship for health and can increase sources of information both from health workers and schools and the teacher council, through print media and electronics so that its reach is getting wider.

 

Berdasarkan Riskesdas 2007 sebesar 34,2%, Riskesdas 2010 sebesar 34,3% dan Riskesdas 2013 menjadi 36,3%. Tujuan penelitian ini adalah untuk mengetahui Gambaran Pengetahuan dan Sikap Remaja Tentang Rokok dan Bahayanya di SMP Negeri 9 Bandung. Desain penelitian ini adalah deskriptif. Populasi pada penelitian ini adalah remaja kelas VII dan VIII SMP Negeri 9 Bandung. Teknik sampling menggunakan metode stratified random sampling dengan jumlah  sampel 246 responden. Instrumen yang digunakan dalam penelitian ini adalah kuesioner untuk mengetahui pengetahuan dan sikap remaja tentang rokok dan bahayanya. Berdasarkan hasil penelitian Gambaran Pengetahuan Remaja Tentang Rokok dan Bahayanya di SMP Negeri 9 Bandung 2020 hampir setengah responden berada pada kategori cukup yaitu 94 orang (38,2%). Dan Gambaran Sikap Remaja Tentang Rokok dan Bahayanya di SMP Negeri 9 Bandung 2020 lebih dari setengah responden berada pada kategori sikap cukup mendukung yaitu 164 orang (66,7%). Disarankan bagi institusi pendidikan SMP Negeri 9 Bandung agar dapat memberikan informasi mengenai rokok dan bahayanya terutama mengenai kandungan rokok dan sikap yang dipengaruhi oleh pergaulan/ pertemanan bagi kesehatan serta dapat meningkatkan sumber informasi baik dari petugas kesehatan maupun pihak sekolah serta dewan guru, melalui media cetak dan elektronik agar jangkauannya semakin luas.
Inverted nipples: a postpartum care case report
Authors: Alifah Andini Najla , Ni Wayan Dian Ekayanthi , Ni Wayan Dian Ekayanthi , Fauzia Fauzia
Published: November 2023

Masa nifas adalah masa yang dimulai setelah plasenta lahir dan berakhir

ketika alat-alat kandungan kembali seperti keadaan sebelum hamil yang

berlangsung sekitar 6 minggu. Pada masa ini terjadi perubahan dan adaptasi

secara fisiologis, namun dapat juga terjadi penyulit salah satuya berkaitan dengan

laktasi, yaitu puting susu tenggelam. Puting susu tenggelam disebabkan karena

saluran susu pendek ke dalam (inverted nipples) yang dapat mengakibatkan ibu

kesulitan dalam menyusui bayinya. Tujuan penyusunan asuhan pada Ny. M usia 18

tahun P1A0 di PMB S adalah untuk memberikan gambaran asuhan kebidanan pada

ibu post partum pada Ny. M usia 18 tahun dengan puting susu tenggelam di PMB

S Kabupaten Bogor.

Metode yang digunakan dalam penyusunan Laporan Tugas Akhir ini adalah

laporan kasus dengan pendokumentasian SOAP (Data Subjektif, Objektif,Analisa,

dan Penatalaksanaan). Teknik pengumpulan data dengan wawancara, observasi,

pemeriksaan fisik, studi dokumentasi dan studi literatur.

Dari data subjektif diperoleh data Ny. M usia 18 tahun melahirkan anak

pertama, tidak pernah mengalami keguguran. Ibu belum paham menyusui yang

benar. Selain itu, puting susu sebelah kiri masuk ke dalam, puting susu kanan

menonjol sehingga ibu mengalami kesulitan menyusui bayinya. Hasil

pemeriksaan didapatkan tanda-tanda vital dalam keadaan normal, puting susu

sebelah kiri tenggelam, TFU 2 jari di bawah pusat, kontraksi keras, kandung

kemih kosong, lokia rubra, jahitan utuh. Analisa yang didapat Ny. M usia 18

tahun P1A0 post partum 2 jam dengan puting susu tenggelam. Penatalaksaan yang

dilakukan yaitu mengajarkan ibu mengenai teknik Hoffman, cara menggunakan

pompa ASI dan teknik menyusui yang benar.

Kesimpulan dari asuhan yang telah diberikan yaitu keluhan puting susu

tenggelam menjadi puting datar dengan menggunakan perasat Hoffman dan

penggunaan pompa ASI. Setelah diberikan asuhan ibu mampu menyusui bayi

dengan baik. Adapun saran yang diberikan kepada ibu dan keluarga adalah tetap

melanjutkan dan konsisten dalam melakukan asuhan yang telah diberikan.
LAPORAN KASUS IBU HAMIL 36 MINGGU DENGAN ANEMIA SEDANG
Authors: Dwisha Aulyzra Vira , Sasnitiari Ni Nyoman Sasnitiari
Published: November 2023

Anemia dalam kehamilan adalah kondisi ibu dengan kadar haemoglobin dibawah 11 gr% pada trimester I dan III atau kadar <10,5 gr% pada trimester II. Menurut Riskesdas tahun 2018, proporsi anemia ibu hamil sekitar 48,9% disebabkan oleh keadaan kesehatan gizi yang rendah selama kehamilan. Pada kunjungan ANC di PMB Bidan A selama bulan Januari – Maret 2022 yaitu dari 176 orang yang melakukan kunjungan ANC, didapatkan presentase ibu dengan Anemia dalam Kehamilan sebesar 5,68%.

Tujuan penulisan Laporan Tugas Akhir ini adalah menerapkan Asuhan Kebidanan pada Ny. S G1P0A0 hamil 36 minggu dengan anemia sedang di PMB A menggunakan metode laporan kasus dan pendokumentasian SOAP. Teknik pengumpulan data melalui wawancara, pemeriksaan fisik dan laboratorium, observasi, studi dokumentasi, dan studi literatur.

Data subjektif yang diperoleh ibu mengeluh pusing, lemas, dan mudah lelah. Ini adalah kehamilan pertama dan belum pernah keguguran. HPHT 21-06-2021 dengan Hb = 9,5 gr/dl (23-02-2022) di Rumah Sakit. Data objektif, tekanan darah 110/70 mmHg, nadi 80 x/m, respirasi 22 x/m, suhu 36,6℃, konjungtiva pucat, TFU 30 cm, puki, dan belum masuk panggul, TBJ 2635 gram dan DJJ 140 x/menit, ekstremitas pucat dan reflek patella positif. Analisa Ny. S usia 24 tahun G1P0A0 hamil 36 minggu dengan anemia sedang, janin tunggal, hidup, intrauterine, presentase kepala. Penatalaksanaan; edukasi nutrisi gizi seimbang, pemberian tablet tambah darah hingga kadar Hb membaik.

Kesimpulan yaitu asuhan yang diberikan sudah tepat dan anemia tertangani dengan baik. Disarankan ibu tetap mengonsumsi tablet tambah darah hingga pascasalin serta mengonsumsi makanan dengan gizi seimbang
KORELASI VULVA HYGINE DAN PERAN ORANGTUA TERHADAP KEJADIAN LEUKOREA
Authors: Ruliani Syarifah Nur , Chanafy Novyanthy
Published: November 2023

Keputihan dalam istilah medis Leukorrhea atau Flour Albus adalah cairan yang keluar dari lubang vagina. Keputihan yang terjadi pada wanita kebanyakan merupakan gejala saja. Keputihan terjadi karena faktor kondisi tubuh. Tujuan penelitian adalah untuk mengetahui hubungan vulva hygiene dengan peran orang tua terhadap kejadian keputihan. Penelitian ini merupakan jenis penelitian kuantitatif analitik. Desain penelitian yang digunakan adalah cross sectional study. sampel dalam penelitian ini adalah siswi SMK Bunda Auni Bekasi sebanyak 45 responden. Penentuan sampel dalam penelitian ini menggunakan teknik total sampling. Peneliti menggunakan uji Chi Square. berdasarkan hasil penelitian tidak ada hubungan antara vulva hygiene dengan kejadian keputihan dengan nilai P = 0,690 > 0,05 dan ada hubungan peran orang tua dengan kejadian keputihan dengan nilai P = 0,018 <0,05 Diharapkan perawat sebagai bagian integral dari pelayanan kesehatan dapat meningkatkan kesadaran masyarakat akan pentingnya kesehatan reproduksi dan peran orang tua bagi remaja melalui pendidikan kesehatan dalam upaya pencegahan leukorea.
Asuhan Kebidanan Kehamilan Dengan Abortus Imminens
Authors: Raymala Raymala , Purnamasari Gilang
Published: November 2023

Kehamilan adalah masa dimulai dari konsepsi sampai lahirnya janin. Komplikasi yang dapat terjadi dalam kehamilan salah satunya adalah abortus. Komplikasi yang mungkin terjadi pada kejadian abortus diantaranya perdarahan, perforasi, infeksi dan syok. Berdasarkan data yang di dapatkan di RSU Salak Bogor terdapat angka kejadian abortus sebanyak 23 kasus (48,9%) dari bulan September 2021-Februari 2022. Berdasarkan tingginya angka abortus tersebut itu penulis tertarik  untuk memberikan asuhan pada Ny. S Usia 43 Tahun dengan Abortus Imminens di RSU Bogor.

Metode yang digunakan dalam penyusunan Laporan Tugas Akhir adalah laporan kasus, dengan menggunakan pendekatan manajemen kebidanan dalam bentuk pendokumentasian SOAP. Teknik pengumpulan data melakukan wawancara dan pemeriksaan fisik.

Data subjektif yang diperoleh, pada tanggal 19 maret 2022  Ny. S usia 43 tahun hamil 9 minggu mengeluh keluar bercak darah dari jalan lahir dan merasa sedikit mula. Pada tanggal 20 Maret 2022 pengeluaran darah semakin banyak dan adanya gumpalan darah. Data objektif diperoleh, tanda-tanda vital normal. Terdapat nyeri tekan di perut bagian bawah, adanya pengeluaran darah pervaginam sebanyak 10cc dan tidak ada jaringan yang keluar. Analisa yang didapat yaitu Ny.S usia 43 tahun G3P2A0 dengan abortus imminens. Penatalaksanaan yang dilakukan yaitu kolaborasi dengan dokter, tirah baring, terapi obat Allylestrenol 3x5mg, tablet Fe, Asam folat, vit.D 1000iu dan memberikan support emosional.

Kesimpulan kasus ini yaitu setelah diberikan penanganan abortus imminens sesuai dengan SOP Rumah Sakit Salak kehamilan Ny.S tidak dapat dipertahankan dan dilakukan kuretase tanggal 21 maret 2022. Saran untuk lahan praktik diharapkan tetap mempertahankan pelayanan sesuai dengan SOP khususnya pelayanan kebidanan dengan abortus. Saran bagi profesi dapat lebih meningkatkan kualitas asuhan sesuai dengan teori yang terus berkembang namun tetap berdasarkan wewenangnya. Untuk Klien ibu mampu memahami tanda bahaya kehamilan dan merencanakan metode kontrasepsi mantap.