bluuebunny/crossref_metadata_2025 huggingface dataset:
STRATEGI PEMBELAJARAN GURU PENDIDIKAN AGAMA ISLAM DALAM MENINGKATKAN PRESTASI BELAJAR PESERTA DIDIK
Authors: Ishak Ishak , Walid Abdul
Published: August 2023

Tujuan utamanya yang ingin dicapai dari penelitian ini adalah untuk mengetahui strategi pembelajaran guru Pendidikan Agama Islam dalam meningkatkan prestasi belajar peserta didik di SMP Negeri 1 Patampanua Pinrang. Jenis metode yang dipakai dalam penelitian ini adalah metode kualitatif deskriptif yang memberikan gambaran tentang situasi dan kondisi serta kejadian secara sistimatis dan faktual mengenai faktor-faktor, sifat-sifat antara fenomena yang dimiliki untuk melakukan akumulasi dasar dimana pada umumnya menerangkan, memperkuat pengamatan serta mendapatkan makna dari permasalahan yang hendak dicapai. Teknik analisis data yang digunakan analisis data kualitatif sesuai dengan jenis data yang diperoleh. Dari pengamatan, wawancara, catatan wawancara, catatan lapangan. Untuk menguji validitas data, peneliti mencocokkan dan membandingkan data dari berbagai sumber, baik sumber lisan (hasil wawancara), tulisan (pustaka), maupun dari observasi (pengamatan). Data hasil pengaatan, dan wawancara penulis dengan para pendidik yang menyatakan bahwa strategi pembelajaran pada peserta didik tergolong baik karena dilakukan tiga tahapa dalam pembelajaran yakni tahap pendahuluan, kegiatan inti dan kegiatan penutup. Masing masing kegiatan tersebut dilaksanakan sesuai dengan konsep perencanaan pebelajaran. Sedangkan peningkatan prestasi belajar peserta didik dilakukan dengan evaluasi, dengan kegitan evaluasi atau penilaian tersebut dapat menjadi tolak ukur atas kesuksesan guru didalam mengajar, dan dapat diketahui tingkat pemahaman materi yang telah disampaikan oleh guru, sehingga diperoleh hasil bahwa setelah melakukan strategi pembelajaran terdpat peningkatkan prestasi belajar peserta khususnya pada mata pelajaran PAI dan kegiatan bisa dilakukan melalui observasi kelas maupun observasi lingkungan pada peserta didik.
PEREMPUAN, EKONOMI, DAN ALASAN PERCERAIAN
Authors: Meidyawati Meidyawati , Qodir Abdul
Published: August 2023

Latar belakang perceraian yang ada di masyarakat umumnya biasanya disebabkan oleh beberapa hal seperti masalah ekonomi, KDRT, perbedaan pola pikir, adanya orang ketiga serta pernikahan tanpa dilandasi dengan cinta. Tujuan dalam penelitian adalah untuk mengetahui tentang bagaimana perempuan, ekonomi dan alasan perceraian ditinjau dari teori Karl Marx. Metode yang digunakan adalah metode analisis dari beberapa sumber jurnal dari penelitian terdahulu terkait permasalahan perceraian yang diakses melalui internet. Metode penelitian ini lebih ke arah metode kajian atas gagasan konseptual dengan menyajikan data yang dikumpulkan untuk dianalisis bertumpu pada ketersediaan sumber data di perpustakaan (Library Research). Teknik analisis data menggunakan teknik Analisis isi (content analysis). Hasil dalam penelitian ini menunjukkan kesenjangan antara laki-laki dan perempuan, tingginya pendapatan istri dibandingkan dengan suami menyebabkan perbandingan kelas. Pasangan dengan pendapatan yang lebih tinggi cenderung ingin memutuskan prioritas pengeluaran mereka. Hal ini kemudian menabur benih perselisihan yang berujung pada gugatan cerai.
PENGGUNAAN MEDIA SEBAGAI SUMBER INFORMASI PEMILU PILPRES DAN PILEG 2024 DI KALANGAN MAHASISWA PERGURUAN TINGGI KEAGAMAAN NEGERI DI PALANGKA RAYA
Authors: Safitri Siti Noraulva , Syah Hakim , Setiawan Heri
Published: August 2023

General election is a manifestation of democracy. Since Indonesia independence, general election has been carried out using various electoral systems. After the reform in 1998, the electoral system involved direct people's participation as a manifestation of people's sovereignty. General election in Indonesia is held every five years. Currently, the General Selection Commission is preparing everything regarding the general election in 2024, both the legislative and presidential elections. Information regarding general election is indeed important for the people, and the media plays an important role in providing various information regarding general election. In other words, the media acts as a means of political communication. This research aimed to describe the perspectives or opinions of students of three State Religious Institutions in Palangka Raya regarding general election information and the media used as the source of information. This research was a descriptive qualitative research,  the data was collected by using in-depth interview and documentation. A total of 10 students became the key informants who were selected and determined based on purposive sampling. The results of the research showed that the majority of students thought that the media was an important source of information regarding general election, and in general, social media platforms were used as the main source of information besides the types of mainstream media or internet media. Based on the types of election information categories, the majority of informants stated that information regarding candidates and election processes or mechanisms was the information they wanted to know the most. The informants also stated that they had participated directly in general election, even though only as beginner voters because they believed that as good citizens they should have used their right to vote responsibly.
PENERAPAN KEBIJAKAN PUBLIK DALAM UPAYA PENCEGAHAN PERTAMBANGAN ILLEGAL BAHAN GALIAN C (STUDI KASUS DI KECAMATAN BATAUGA KABUPATEN BUTON SELATAN)
Authors: Endrawati Hesti
Published: August 2023

Indonesia is known as a producer of abundant natural resources, one of which is mining materials such as sand, gold, copper, nickel, coal, tin. The existence of a wealth of mining materials in Indonesia raises polemics regarding illegal mining activities or mining without permits. Batauga District is one of the areas in South Buton Regency which has the potential for mining C in the form of a sand mine which can produce in quite large quantities. With the potential for sand mining in Batauga District, it has negative impacts related to environmental preservation. Therefore, this study aims to analyze the application of public policy in preventing the mining of mineral C in Batauga District, South Buton Regency. The method used in this research is qualitative by using literature study techniques. The findings from this research are that the implementation of mineral C mining policies in Batauga District in preventing illegal mining is still low, both in terms of organizational activities, interpretation and application. solutions that can be applied to overcome the problem of illegal mining in Batauga District, include: the reformulation of regulations, the government making repressive efforts, improving bureaucracy, and the Government conducting outreach to the community.
The Application of True Sale Contract In Asset-Backed Sukuk
Authors: Zakaria Mohamad zaharuddin
Published: August 2023

This article discusses the concept of true sale and its application in sukuk issuance whereby the existence of this concept is vital to ensure the permissibility of sukuk issuance especially for asset-backed sukuk.  The purpose of this study is to differentiate the application of true sale contract in asset-based and asset-backed sukuk and to examine whether the concept of true sale involved therein is similar to the Shariah concept of sale. Thus the sukuk underlying contracts are analyzed in order to understand the concept and the practice of both asset-based and asset-backed sukuk. Finally, the study found that the true sale contract is really practiced in asset-backed sukuk but not in asset-based sukuk which make the previous comply with the shariah concept of sale whereby the later although did not apply the true sale contract but still the sukuk is comply with shariah rules.
Standardisation of Dietary and Medication Restrictions for Urine 5-Hydroxyindoleacetic Acid (5-HIAA) Collection
Authors: Mukerji Shohini , Chiang Cherie , Woollard Gerald , Choy Kay Weng , Ding Lucy
Published: August 2023

The dietary restriction advice provided by Australian clinical laboratories to patients prior to 24-hour urine collection of 5-hydroxyindoleacetic acid (5-HIAA) has not been standardised. Variation exists between the lists of foods and medications patients are requested to avoid and in the duration for which the restrictions must be applied. Furthermore, the evidence for some of these restrictions is limited or outdated. A review of current literature identified that the main foods which significantly elevate urine 5-HIAA levels are plantain, banana, walnuts, hickory nuts, pineapple, plums, tomatoes, kiwifruits and avocados. These need to be avoided for at least two days prior to and during the collection period. Alcohol should be avoided for a minimum of one day before the collection and dietary supplements containing 5-hydroxytryptophan should be avoided for at least 14 days prior. Certain medications may cause false elevations of 5-HIAA but many are dependent on the assay used. Contrary to historical recommendations, we found insufficient information to warrant restriction of eggplant/aubergine, coffee, tea, milk chocolate and vanilla.
In-depth cytogenetic and immunohistochemical analysis in a real world cohort - reconsidering the role of primary and secondary aberrations in multiple myeloma
Authors: Wenger Sina , Pantic Milena , Ihorst Gabriele , Cysar Stepan , Calba Marc-Antoine , Greil Christine , Wäsch Ralph , Engelhardt Monika
Published: August 2023

Not available.
PESAN KEMANUSIAAN DALAM FILM THE DOUGHTER OF WAR
Authors: Armaini Weni , Masruroh Sayidah Afyatul
Published: August 2023

Abstrak: Artikel ini mendeskripsikan pesan kemanusiaan yang terdapat dalam film â€œThe Doughter Of Warâ€ karya Can Ulkay. Penelitian ini bertujuan untuk mengetahui bagaimana tanda dan makna pesan kemanusiaan yang diceritakan dalam film tersebut. Penelitian ini merupakan penelitian kualitatif dengan menggunakan analisis semiotika Roland Barthes. Hasil penelitian ini menujukkan bahwa bentuk pesan kemanusiaan dalam film The Doughter Of War yakni berupa makna denotasi, konotasi, dan mitos. Makna denotasi yang terdapat pada film The Doughter Of War berupa rangkaian konflik serta solusi dari segala permasalahan yang datang saat Korea Selatan mendapat serangan dari Korea Utara hingga kisah Suleyman untuk menemukan Ayla. Makna konotasi yang terdapat pada beberapa adegan film yang sudah dianalisis di atas berupa adanya kasih sayang, perjuangan, pengorbanan, doâ€™a, ikhtiar, tanggung jawab, tolong menolong, usaha, serta nasihat hidup, sehingga melahirkan mitos yang mengandung pesan-pesan positif, ataupun nasihat yang berhubungan dengan moralitas.  Terdapat 13 adegan pada film The Doughter Of War yang mengandung pesan kemanusiaan yang diukur sesuai indikator kemanusiaan menurut Nurgiayantoro, yakni hubungan manusia dengan sesama manusia yang mencakup kasih sayang orang tua terhadap anak, persahabatan, tolong menolong, dan saling menasehati. Hubungan manusia dengan tuhannya yang mencakup ketaatan menjalankan perintahNya. Hubungan manusia dengan dirinya sendiri yang mencakup keharusan belajar untuk meningkatkan kualitas diri. Dan hubungan manusia dengan alam yang mencakup usaha untuk memperbaiki alam yang telah dirusak. Peneliti berargumen bahwa pesan kemanusiaan sangat perlu disampaikan melalui sebuah media guna menumbuhkan kesadaran masyarakat, mengingat saat ini banyak perilaku yang kurang memanusiakan manusia.
PESAN MORAL DALAM FILM 100% HALAL KARYA JASTIS ARIMBA
Authors: Fauzi Achfaz , Anwari
Published: August 2023

Abstract: Pada dasarnya film merupakan sebuah karya seni yang terlahir dari para pemeran suatu karakter. Hakikatnya film yang ditayangkan di televisi atau di bioskop dapat mempengaruhi dan membentuk khalayak sesuai dengan muatan pesan di dalamnya, tanpa berlaku sebaliknya. Di dalam sebuah karya seni film beragam isi pesan yang mencakup pesan edukatif, informatif, pesan religi, moral dan sebagainya. Penyampaian pesan religi atau agama dimanfaatkan film sebagai salah satu sarana dakwah karena tidak sedikit pihak yang memanfaatkan film tersebut. Salah satunya Film 100% Halal Karya Jastis Arimba yang diproduseri oleh Raam Punjabi dan diproduksi oleh MVP Pictures. Film ini menceritakan Ilham Sentosa (Ariyo Wahab), seorang motivator dan penulis sukses yang menganjurkan untuk pernikahan muda. Melihat pemaparan dari fenomena tersebut maka peneliti akan mengulas pesan moral yang terdapat dalam film 100% Halal. Adapun rumusan masalah dalam skripsi ini adalah Bagaimana makna tanda yang terdapat dalam film 100% Halal Karya Jastis Arimba. Untuk menjawab rumusan masalah tersebut, peneliti menggunakan pendekatan kualitatif deskriptif dengan menggunakan metode analisis semiotika teori Charles Sanders Pierce. Adapun Unit analisis data berupa setiap adegan atau scene yang mengandung makna pesan moral dalam film 100% Halal. Tahapan penelitiannya dibagi menjadi beberapa bagian seperti: mencari topik, merumuskan masalah, menentukan metode penelitian, mengumpulkan data, menganalisis data, dan menarik kesimpulan. Dari hasil analisis yang dilakukan peneliti menghasilkan kesimpulan berupa makna tanda yang dikembangkan Charles Sanders Pierce dengan menggunakan segitiga makna yang meliputi: ikon, indeks dan simbol. Ketiga struktur tanda tersebut merupakan rangkaian yang saling berkaitan dari makna tanda yang sudah di sajikan dalam bentuk penyajian data berupa beberapa adegan dan kemudian di analisa menggunakan teori segitiga makna. Dan menghasilkan pesan moral dengan menggunakan teori yang di kembangkan oleh Franz Magnis Suseno yang meliputi: kejujuran dalam ucapan. Menjadi diri sendiri dalam menentukan pilihan. Bertanggung jawab atas kewajiban dan bertanggung jawab sebagai seorang suami. Kemandirian menjadi seorang ibu yang tangguh, dan bertindak atas kehendak sendiri. Keberanian moral untuk memberanikan diri meminang seorang wanita. Kerendahan hati dengan membantu dan menolong sesama, kerendahan hati menjadi seorang suami. Dan kritis dalam menghadapi suatu hal memberikan nasihat yang baik.
ANALISIS ISI CERAMAH BUYA YAHYA â€œKETIKA UJIAN HIDUP TERASA MELELAHKANâ€ PADA CHANNEL YOUTUBE AL-BAHJAH TV
Authors: Maghfiroh Lailatul , Masruroh Sayidah Afyatul
Published: August 2023

Buya Yahya dalam waktu singkat telah mendapat banyak perhatian dari masyarakat dalam upaya penyebaran dakwah Islam pada media sosial youtube melalui channel Al-Bahjah TV. Hal ini karena cara pembawaan Buya Yahya dalam ceramahnya yang selalu terdengar dan terlihat menarik, penggunaan bahasa yang mudah difahami, ceramah-ceramahnya yang tidak hanya di konsumsi oleh masyaakat Indonesia tetapi juga sampai keluar negri. Penelitian ini berfokus pada, pesan ceramah Buya Yahya â€œKetika Ujian Hidup Terasa Melelahkanâ€ pada channel youtube Al-Bahjah TV. Hasil penelitian ini menunjukkan bahwa pesan ceramah Buya Yahya yang terdapat dalam channel youtube Al-Bahjah TV dengan judul â€œKetika Ujian Hidup Terasa Melelahkanâ€ adalah pesan aqidah meliputi keimanan manusia kepada Allah. Pesan akhlak meliputi tingkah laku dan sifat seseorang dalam kehidupan sehari-hari seperti sabar, saling memaafkan, lapang dada, selalu hidup damai dan tiak saling iri dengki, sombong, adu domba, hasut. Dan pesan syariâ€™at meliputi masalah-masalah peribadatan dan hukumnya. Peneliti berargumen bahwa pesan dakwah tersebut sangat relevan dengan kondisi perkembangan zaman saat ini, karena berupa pesan kewaspadaan terhadap informasi-informasi yang beredar, karena tidak semuanya berasal dari sumber yang benar
PERILAKU BERMEDIA SOSIAL PADA SANTRI MAHASISWA PONDOK PESANTREN AL-ISTIQOMAH CUKIR DIWEK JOMBANG JAWA TIMUR
Authors: Sholikah Lathifatul , Anwari
Published: August 2023

Pondok Pesantren Al-Istiqomah Cukir, Diwek, Jombang memiliki kebijakan memperbolehkan santri menggunakan gadget atau media sosial. Penelitian ini bertujuan untuk mengetahui pengaruh media sosial terhadap perilaku santri, menjelaskan mengenai apa saja pengaruh media sosial bagi santri di masa perkembangannya kemudian untuk mengetahui apa saja pengaruh terhadap perilaku santri yang disebabkan oleh media sosial saat ini. Penelitian ini menganalisis mengenai perubahan perilaku santri yang menggunakan media sosial dan pengaruh penggunaan media sosial bagi santri mahasiswa Pondok Pesantren Al-Istiqomah. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif. Dari hasil penelitian ini menunjukkan bahwa ada perubahan perilaku pada santri Pondok Pesantren Al-Istiqomah yang menggunakan media sosial. Perubahan yang terjadi dapat dilihat dari tata krama/etika, kecanduan media, dan kurang interaksi dengan santri lingkungan sekitarnya. Penggunaan media sosial memberikan dampak positif dan negatif bagi santri. Dampak positifnya antara lain memberikan wawasan yang luas kepada santri, untuk menambah relasi dan informasi. Sedangkan, dampak buruk penggunaan media sosial bagi santri yaitu mengurangi minat belajar, malas mengikuti kegiatan dan penyalahgunaan media sosial untuk hal-hal yang merugikan.
Determination of polar bear (Ursus maritimus) individual genotype and sex based on DNA extracted from paw-prints in snow
Authors: Von Duyke Andrew L. , Crawford Justin A. , Quakenbush Lori , Adams Jennifer R. , Waits Lisette P.
Published: August 2023

Polar bears rely upon sea ice to hunt, travel, and reproduce. Declining sea ice extent and duration has led polar bears to be designated as “threatened” (ESA). Population monitoring is vital to polar bear conservation; but recently, poor sea ice has made traditional aircraft-based methods less viable. These methods largely rely upon the capture and handling of polar bears, and have been criticized over animal welfare concerns. Monitoring polar bears via DNA sampling is a promising option. One common method utilizes biopsy darts delivered from a helicopter to collect DNA, a method that faces similar ice associated challenges to those described above. However, epidermal cells shed from the foot pads of a polar bear into its paw-prints in snow are a source of “environmental DNA” (e-DNA) that can be collected non-invasively on the sea ice or on land for potential use in population monitoring. Mitochondrial DNA (mt-DNA) is used to assess whether polar bear DNA is present within a snow sample, and nuclear DNA (n-DNA) can identify individuals and their sex. The goal of this investigation was to assess the viability of using e-DNA collected from paw-prints in the snow to identify individual polar bears and their sex. Snow was sampled from 13 polar bear trails (10 paw-prints per trail) on the sea ice in the Chukchi and Beaufort seas along the North Slope of Alaska. Species verification was based on a mt-DNA PCR fragment analysis test. Identification of individuals was accomplished by amplifying a multiplex of seven n-DNA microsatellite loci, and sex was determined by the amelogenin gene sex ID marker. Six of the 13 bear trails sampled (46%) yielded consensus genotypes for five unique males and one female. To our knowledge, this is the first time that polar bears have been individually identified by genotype and sex using e-DNA collected from snow. This method is non-invasive, could be integrated into genetic mark-recapture sampling designs, and addresses some of the current challenges arising from poor sea ice conditions. It also can involve, engage, and empower Indigenous communities in the Arctic, which are greatly affected by polar bear management decisions.
Evolution of T cell receptor beta loci in salmonids
Authors: Boudinot Pierre , Novas Samuel , Jouneau Luc , Mondot Stanislas , Lefranc Marie-Paule , Grimholt Unni , Magadán Susana
Published: August 2023

T-cell mediated immunity relies on a vast array of antigen specific T cell receptors (TR). Characterizing the structure of TR loci is essential to study the diversity and composition of T cell responses in vertebrate species. The lack of good-quality genome assemblies, and the difficulty to perform a reliably mapping of multiple highly similar TR sequences, have hindered the study of these loci in non-model organisms. High-quality genome assemblies are now available for the two main genera of Salmonids, Salmo and Oncorhynchus. We present here a full description and annotation of the TRB loci located on chromosomes 19 and 25 of rainbow trout (Oncorhynchus mykiss). To get insight about variations of the structure and composition of TRB locus across salmonids, we compared rainbow trout TRB loci with other salmonid species and confirmed that the basic structure of salmonid TRB locus is a double set of two TRBV-D-J-C loci in opposite orientation on two different chromosomes. Our data shed light on the evolution of TRB loci in Salmonids after their whole genome duplication (WGD). We established a coherent nomenclature of salmonid TRB loci based on comprehensive annotation. Our work provides a fundamental basis for monitoring salmonid T cell responses by TRB repertoire sequencing.
New insight on the enteric cholinergic innervation of the pig colon by central and peripheral nervous systems: reduction by repeated loperamide administration
Authors: Yuan Pu-Qing , Li Tao , Million Mulugeta , Larauche Muriel , Atmani Karim , Bellier Jean-Pierre , Taché Yvette
Published: August 2023

Introduction

The central and peripheral nervous systems provide cholinergic innervation in the colon. The ability to assess their neuroanatomical distinctions is still a challenge. The pig is regarded as a relevant translational model due to the close similarity of its enteric nervous system (ENS) with that of human. Opioid-induced constipation is one of the most common side effects of opioid therapy.

Methods

We developed an approach to differentiate the central and peripheral cholinergic innervation of the pig colon using double immunolabeling with a novel mouse anti-human peripheral type of choline acetyltransferase (hpChAT) antibody combined with a rabbit anti-common type of ChAT (cChAT) antibody, a reliable marker of cholinergic neurons in the central nervous system. We examined their spatial configurations in 3D images of the ENS generated from CLARITY-cleared colonic segments. The density was quantitated computationally using Imaris 9.7. We assessed changes in the distal colon induced by daily oral treatment for 4  weeks with the μ opioid receptor agonist, loperamide (0.4 or 3  mg/kg).

Results

The double labeling showed strong cChAT immunoreactive (ir) fibers in the cervical vagus nerve and neuronal somata and fibers in the ventral horn of the sacral (S2) cord while hpChAT immunoreactivity was visualized only in the ENS but not in the vagus or sacral neural structures indicating the selectivity of these two antibodies. In the colonic myenteric plexus, dense hpChAT-ir neurons and fibers and varicose cChAT-ir fibers surrounding hpChAT-ir neurons were simultaneously visualized in 3D. The density of cChAT-ir varicose fibers in the outer submucosal plexus of both males and females were higher in the transverse and distal colon than in the proximal colon and in the myenteric plexus compared to the outer submucosal plexus and there was no cChAT innervation in the inner submucosal plexus. The density of hpChAT in the ENS showed no segmental or plexus differences in both sexes. Loperamide at the highest dose significantly decreased the density hpChAT-ir fibers + somata in the myenteric plexus of the distal colon.

Discussion

These data showed the distinct density of central cholinergic innervation between myenteric and submucosal plexuses among colonic segments and the localization of cChAT-ir fibers around peripheral hpChAT neurons in 3D. The reduction of cholinergic myenteric innervation by chronic opiate treatment points to target altered prokinetic cholinergic pathway to counteract opiate constipation.
An improved model using convolutional sliding window-attention network for motor imagery EEG classification
Authors: Huang Yuxuan , Zheng Jianxu , Xu Binxing , Li Xuhang , Liu Yu , Wang Zijian , Feng Hua , Cao Shiqi
Published: August 2023

Introduction

The classification model of motor imagery-based electroencephalogram (MI-EEG) is a new human-computer interface pattern and a new neural rehabilitation assessment method for diseases such as Parkinson's and stroke. However, existing MI-EEG models often suffer from insufficient richness of spatiotemporal feature extraction, learning ability, and dynamic selection ability.

Methods

To solve these problems, this work proposed a convolutional sliding window-attention network (CSANet) model composed of novel spatiotemporal convolution, sliding window, and two-stage attention blocks.

Results

The model outperformed existing state-of-the-art (SOTA) models in within- and between-individual classification tasks on commonly used MI-EEG datasets BCI-2a and Physionet MI-EEG, with classification accuracies improved by 4.22 and 2.02%, respectively.

Discussion

The experimental results also demonstrated that the proposed type token, sliding window, and local and global multi-head self-attention mechanisms can significantly improve the model's ability to construct, learn, and adaptively select multi-scale spatiotemporal features in MI-EEG signals, and accurately identify electroencephalogram signals in the unilateral motor area. This work provided a novel and accurate classification model for MI-EEG brain-computer interface tasks and proposed a feasible neural rehabilitation assessment scheme based on the model, which could promote the further development and application of MI-EEG methods in neural rehabilitation.
Identification of polyunsaturated fatty acids as potential biomarkers of osteoarthritis after sodium hyaluronate and mesenchymal stem cell treatment through metabolomics
Authors: Yang Qinyan , Zhao Yiran , Li Na , Wu Jian-Lin , Huang Xiaolun , Zhang Mei , Bian Xiqing , Zhu Yi-Zhun
Published: August 2023

Introduction: Osteoarthritis (OA) is a prevalent joint disorder worldwide. Sodium hyaluronate (SH) and mesenchymal stem cells (MSCs) are promising therapeutic strategies for OA. Previous studies showed they could improve knee function and clinical symptoms of OA. However, the mechanism of the therapeutic effects on the improvement of OA has not been clearly explained.

Methods: In our study, we used a technique called 5-(diisopropylamino)amylamine derivatization liquid chromatography coupled with mass spectrometry to find the metabolites in OA synovial fluid under different treatments.

Results and Discussion: After looking into the metabolomics, we discovered that SH and MSC treatment led to the downregulation of ω-6 polyunsaturated fatty acids (PUFAs) and the upregulation of ω-3 PUFAs. Significantly, the contents of 5(S)-HETE, PGA2, PGB2, and PGJ2 were lower in the MSC group than in the SH group after quantification using 5-(diisopropylamino)amylamine derivatization–UHPLC–QQQ-MS. This is the first report on the relationship of 11(S)-HETE, PGA2, PGB2, PGF2β, 11β-PGF2α, and DK-PGE2 with OA. Moreover, the correlation analysis of metabolites and inflammation factors showed the positive association of ω-6 PUFAs with pro-inflammation cytokines, and of ω-3 PUFAs with anti-inflammation cytokines. Our results indicated the therapeutic effect of SH and MSCs in patients with OA. In addition, this reliable metabolic approach could uncover novel biomarkers to treat OA.
Continuous photon energy modulation in IMRT of pancreatic cancer
Authors: Zhang Xile , Zhou Fugen , Liu Bo , Xiong Tianyu , Bai Xiangzhi , Wu Qiuwen
Published: August 2023

Purpose: To develop a novel IMRT optimization method based on the principle of photon energy synthesis that simultaneously optimizes fluence map and beamlet energy. The method was validated on pancreatic cancers to demonstrate the benefits of the additional degree of freedom of photon energy in IMRT.

Methods: Previous work has demonstrated that the effect of a photon beam of known energy can be achieved by the combination of two existing energy photons in the proper ratio. It further implied that any energy photon can be synthesized. Based on this, we propose the concept of continuous beamlet energy modulation in IMRT, or IMRT-BEM. The IMRT-BEM was modeled as the simultaneous optimization of two fluence maps, one for the low energy beam and one for the high energy beam, and it was implemented in an in-house inverse planning system. The IMRT-BEM was applied on 10 pancreatic cancer cases, where the IMRT-BEM plan was compared with single-energy IMRT plans of 6 MV (IMRT-6MV) and 15 MV photons (IMRT-15MV).

Results: The IMRT-BEM plan provides a noticeable reduction to the volume irradiated at the high dose level (PTV105%) for PTV, at least 24.7% (6.4 ± 6.8 vs. 31.1 ± 18.7 (p = 0.005) and 43.8 ± 19.8 (p = 0.005) for IMRT-BEM, IMRT-6MV, and IMRT-15MV respectively). For target dose coverage, there were statistically significant improvements between the IMRT-BEM plans and the other two plans in terms of CI and HI. Compared to the IMRT-6MV plan, there were significant reductions in the Dmean of the spinal cord, liver, bowel, duodenum, and stomach. The irradiation volumes of the medium dose (V20Gy, and V40Gy) for the duodenum and bowel were reduced significantly. There were no significant differences between the IMRT-BEM and IMRT-15MV plans except for the Dmean of the spinal cord and the duodenum, the V20Gy, and V40Gy for the duodenum, and the V20Gy of the stomach.

Conclusion: IMRT-BEM has certain dosimetric advantages for PTV and improves OAR sparing in pancreatic cancer, and can be effectively used in radiation treatment planning, providing another degree of freedom for planners to improve treatment plan quality.
The efficacy of Equine Assisted Therapy intervention in gross motor function, performance, and spasticity in children with Cerebral Palsy
Authors: Stergiou Alexandra N. , Mattila-Rautiainen Sanna , Varvarousis Dimitrios N. , Tzoufi Meropi , Plyta Panagiota , Beris Alexandros , Ploumis Avraam
Published: August 2023

Purpose

To evaluate the efficacy of Equine Assisted Therapy in children with Cerebral Palsy, in terms of gross motor function, performance, and spasticity as well as whether this improvement can be maintained for 2 months after the end of the intervention.

Methods

Children with Cerebral Palsy participated in this prospective cohort study. The study lasted for 28 weeks, of which the equine assisted therapy lasted 12 weeks taking place once a week for 30 min. Repeated measures within the subject design were used for the evaluation of each child’s physical performance and mental capacity consisting of six measurements: Gross Motor Function Measure-88 (GMFM-88), Gross Motor Performance Measure (GMPM), Gross Motor Function Classification System (GMFCS), Modified Ashworth Scale (MAS) and Wechsler Intelligence Scale for Children (WISC III).

Results

Statistically significant improvements were achieved for 31 children in Gross Motor Function Measure and all its subcategories (p < 0.005), also in total Gross Motor Performance Measure and all subcategories (p < 0.005). These Gross Motor Function Measure results remained consistent for 2 months after the last session of the intervention. Regarding spasticity, although an improving trend was seen, this was not found to be statistically significant.

Conclusion and implications

Equine Assisted Therapy improves motor ability (qualitatively and quantitatively) in children with Cerebral Palsy, with clinical significance in gross motor function.
Diffusion tensor imaging tractography in the one-humped camel (Camelus dromedarius) brain
Authors: Cartiaux Benjamin , Amara Abdelkader , Pailloux Ninon , Paumier Romain , Malek Atef , Elmehatli Kefya , Kachout Souhir , Bensmida Boubaker , Montel Charles , Arribarat Germain , Mogicato Giovanni
Published: August 2023

Introduction

Tractography is a technique used to trace the pathways of the brain using noninvasive diffusion tensor imaging (DTI) data. It is becoming increasingly popular for investigating the brains of domestic mammals and other animals with myelinated fibers but the principle of DTI can also apply for those with unmyelinated fibers. In the case of camels, DTI tractography is a promising method for enhancing current knowledge of the brain’s structural connectivity and identifying white-matter tract changes potentially linked to neurodegenerative pathologies. The present study was therefore designed to describe representative white-matter tracts in the one-humped camel DTI tractography.

Methods

Post mortem DTI was used to obtain images of two one-humped camel brains using a 3 Tesla system. T2-weighted images were also acquired to identify regions of interest for each fiber tract and a fiber dissection technique was used to complement the DT images. The main association, commissural, and projection fibers were reconstructed and superimposed on T2-weighted images or fractional anisotropy maps.

Results

The results of the present study show the reconstruction of the most representative tracts, ie the cingulum, the corpus callosum and the internal capsule, in the one-humped camel brain using DTI data acquired post mortem. These DTI results were compared to those from fiber dissection.

Discussion

Anatomy of the cingulum, corpus callosum and internal capsule correlates well with the description in anatomical textbooks and appears to be similar to fibers describe in large animals. Further research will be required to improve and validate these findings and to generate a tractography atlas based on MRI and histological data, as such an atlas would be a valuable resource for future neuroimaging research.
A Framework of Modeling and Simulation Based on Swarm Ontology for Autonomous Unmanned Systems
Authors: Gao Xinghai , Xiao Gang , Xie Kai , Wang Weijia , Fu Yuhua , Chang Chuangye , Wang Zhuoqi
Published: August 2023

For the emerging autonomous swarm technology, from the perspective of systems science and Systems Engineering (SE), there must be novel methodologies and elements to aggregate multiple systems into a group, which distinguish the general components with specific functions. Here, we expect to provide a presentation of their existence in swarm development processes. The inspiration for our approach originates from the integration of swarm ontology, multiparadigm modeling, multiagent systems, cyber-physical systems, etc. Therefore, we chose the model-driven architecture as a framework to provide a method of model representation across the multiple levels of abstraction and composition. The autonomous strategic mechanism was defined and formed in parallel with Concept of Operations (ConOps) analysis and systems design, so as to effectively solve the cognitive problem of emergence caused by nonlinear causation among individual and whole behaviors. Our approach highlights the use of model-based processes and their artifacts in the swarm mechanism to integrate operational and functional models, which means connecting the macro- and micro-aspects in formalism to synthesize a whole with its expected goals, and then to verify and validate within an L-V-C simulation environment.
Hybrid Raman and Laser-Induced Breakdown Spectroscopy for Food Authentication Applications
Authors: Shin Sungho , Doh Iyll-Joon , Okeyo Kennedy , Bae Euiwon , Robinson J. Paul , Rajwa Bartek
Published: August 2023

The issue of food fraud has become a significant global concern as it affects both the quality and safety of food products, ultimately resulting in the loss of customer trust and brand loyalty. To address this problem, we have developed an innovative approach that can tackle various types of food fraud, including adulteration, substitution, and dilution. Our methodology utilizes an integrated system that combines laser-induced breakdown spectroscopy (LIBS) and Raman spectroscopy. Although both techniques emerged as valuable tools for food analysis, they have until now been used separately, and their combined potential in food fraud has not been thoroughly tested. The aim of our study was to demonstrate the potential benefits of integrating Raman and LIBS modalities in a portable system for improved product classification and subsequent authentication. In pursuit of this objective, we designed and tested a compact, hybrid Raman/LIBS system, which exhibited distinct advantages over the individual modalities. Our findings illustrate that the combination of these two modalities can achieve higher accuracy in product classification, leading to more effective and reliable product authentication. Overall, our research highlights the potential of hybrid systems for practical applications in a variety of industries. The integration and design were mainly focused on the detection and characterization of both elemental and molecular elements in various food products. Two different sets of solid food samples (sixteen Alpine-style cheeses and seven brands of Arabica coffee beans) were chosen for the authentication analysis. Class detection and classification were accomplished through the use of multivariate feature selection and machine-learning procedures. The accuracy of classification was observed to improve by approximately 10% when utilizing the hybrid Raman/LIBS spectra, as opposed to the analysis of spectra from the individual methods. This clearly demonstrates that the hybrid system can significantly improve food authentication accuracy while maintaining the portability of the combined system. Thus, the successful implementation of a hybrid Raman-LIBS technique is expected to contribute to the development of novel portable devices for food authentication in food as well as other various industries.
Equipment Disassembly and Maintenance in an Uncertain Environment Based on a Peafowl Optimization Algorithm
Authors: Liu Jiang , Zhan Changshu , Liu Zhiyong , Zheng Shuangqing , Wang Haiyang , Meng Zhou , Xu Ruya
Published: August 2023

Disassembly sequence planning (DSP) is a key approach for optimizing various industrial equipment-maintenance processes. Finding fast and effective DSP solutions plays an important role in improving maintenance efficiency and quality. However, when disassembling industrial equipment, there are many uncertainties that can have a detrimental impact on the disassembly and subsequent maintenance work. Therefore, this paper proposes a multi-objective DSP problem in an uncertain environment that addresses the uncertainties in the disassembly process through stochastic planning, with the objectives of minimizing disassembly time and enhancing responsiveness to priority maintenance components. Due to the complexity of the problem, an improved peafowl optimization algorithm (IPOA) is proposed for efficient problem-solving. The algorithm is specifically designed and incorporates four customized optimization mechanisms: peafowls’ courtship behavior, the adaptive behavior of female peafowls in proximity, the adaptive search behavior of peafowl chicks, and interactive behavior among male peafowls. These mechanisms enable effective search for optimal or near-optimal solutions. Through comparisons with a real-world industrial case and other advanced algorithms, the superiority of the IPOA in solving DSP problems is demonstrated. This research contributes to improving maintenance efficiency and quality, bringing positive impacts to industrial equipment maintenance.
The Influence of Environmental Protection Tax Law on Urban Land Green Use Efficiency in China: The Nonlinear Moderating Effect of Tax Rate Increase
Authors: Peng Cheng , Zhao Lu , Liu Liwen , Chen Jia
Published: August 2023

Due to the basic carrier function of land, the economic and ecological effects of Environmental Protection Tax Law (EPTL) will be reflected in the land use. Therefore, this article investigates the effect of EPTL on land green use efficiency (LGUE). To be specific, based on the panel data of 278 prefecture-level cities in China from 2012 to 2020, LGUE is evaluated through a global super efficiency epsilon-based measure (EBM) with unexpected output. Then, the reform of “sewage fee-to-tax” is regarded as a natural experiment to accurately evaluate the effect of EPTL on LGUE. The result that the implementation of EPTL significantly drives LGUE is confirmed. The mechanism tests show that the implementation of EPTL enhances the intensity of green innovation, promotes the optimization of industrial structure, and thereby improves LGUE. Moreover, we find that the moderating effect of tax rate increase is nonlinear and exhibits an inverted U-shape. That is, below a certain value, the tax rate increase will strengthen the EPTL’s ability to improve LGUE. However, after exceeding the value, the tax rate increase will weaken the EPTL’s ability to improve LGUE. Targeted suggestions are proposed for improving the environmental protection tax system and LGUE.
DATA MINING KLASIFIKASI KEPRIBADIAN SISWA SMP NEGERI 5 JEPARA MENGGUNAKAN METODE DECISION TREE ALGORITMA C4.5
Authors: Kukuh Wahyudi Adjie , Azizah Noor , Saputro Heru
Published: August 2023

Didalam dunia pendidikan, banyak faktor penunjang untuk mencapai keberhasilan dalam proses pembelajaran, mulai dari guru, materi, sampai dengan siswa. Hal yang masih menjadi permasalahan banyak pendidik adalah bagaimana memberikan materi atau pembelajaran dengan berbagai karakter kepribadian siswa yang sampai saat ini masih menjadi kesulitan bagi para pendidik, hal inilah yang mendorong penulis untuk mengangkat penelitian ini, supaya dapat membantu para pendidik untuk mengetahui kepribadian masing-masing siswa. Maka dibuatlah penelitian Data Mining Klasifikasi Kepribadian Siswa Smp Negeri 5 Jepara Menggunakan Metode Decision Tree Algoritma C4.5. Dengan munggunakan metode decision tree algoritma C4.5, data mining ini dapat menghasilkan output yang sempurna dalam mengklasifiaksi kepribadian siswa, dalam studi kasus ini di SMP N 5 Jepara.Hasil tersebut ditunjukkan dengan pengisian kuisioner oleh peneliti kepada 100 siswa dan 1 guru BP SMP Negeri 5 Jepara.
IMPLEMENTASI E-PKL PADA DINAS PERHUBUNGAN JEPARA
Authors: Shabrina Aisyane Aulya , Minardi Joko , Saputro Heru
Published: August 2023

Praktek Kerja Lapangan adalah kegiatan pembelajaran yang bertujuan untuk memperkenalkan dan memperluas keterampilan siswa di dunia kerja nyata. Salah satu tempat PKL yang membuka peluang bagi peserta didik untuk melaksanakan tugas adalah Dinas Perhubungan Jepara. Dinas Perhubungan adalah badan penyelenggara pemerintahan daerah di bidang perhubungan. Namun sayangnya hingga saat ini Dinas Perhubungan Jepara belum memiliki sistem yang dapat memfasilitasi peserta didik dan staf pengurus untuk mengelola kegiatan PKL tersebut. Hal ini mengakibatkan banyak dokumen yang rentang hilang dan tidak terdokumentasi dengan baik. Sistem informasi PKL dengan penilaian kriteria menggunakan skala likert menjadi solusi dalam proses pengelolaan PKL menjadi lebih baik. Aplikasi ini berbasis web agar semua data terkelola dan tersimpan dengan baik. Sistem ini sudah melalui tahapan pengujian black box testing dengan hasil semua fitur, alur, dan program sudah normal dan sesuai dengan yang sudah direncanakan di awal. Selain itu, persentase kelayakan dari hasil pengujian melalui kuesioner kepada 12 responden (user) sistem E-PKL Dinas Perhubungan Jepara mendapatkan skor 90,5% yang artinya sangat layak untuk digunakan.
Instrumento para admissão em uma Unidade de Acidente Vascular Cerebral
Authors: Brandão Gabriela Cristina da Silva , Klitzke Fabiane Maria , Magagnin Adriana Bitencourt
Published: August 2023

Introdução. No âmbito da enfermagem, a propedêutica neurológica visa contribuir na identificação de déficits e intervenções concludentes, possibilitando um desfecho favorável ao paciente. Os checklists são recomendados para subsidiar uma assistência segura e podem incorporar a primeira etapa do processo de enfermagem. Objetivo. Elaborar um checklist para auxiliar a admissão do paciente em uma Unidade de Acidente Vascular Cerebral (AVC) para cuidados integrais, em um hospital público da região Sul do Brasil. Método. Pesquisa descritiva de natureza quali-quantitativa, iniciada com um questionário estruturado composto por 36 itens, avaliados através da escala Likert e posteriormente validados em grupo focal. A análise de conteúdo foi realizada para os dados qualitativos e aos dados quantitativos foi utilizado estatística descritiva, com cálculo de frequência absoluta, percentual e o cálculo do Índice de Validade de Conteúdo, considerado válido os itens que atingiram score total igual ou superior a 100%. Os dados foram tabulados e analisados por meio do software estatístico Statistical Package for Social Science versão 20.0 for Windows (IBM SPSS). Resultados. Dentre os 36 itens avaliados, apenas 7 foram discutidos no grupo focal, elencando-se em categorias da análise temática. Conclusão. O checklist definido pelos participantes traz elementos importantes para a assistência de enfermagem e com aplicação que pode facilitar o processo de trabalho em uma unidade de AVC, qualificando o cuidado. Todavia, requer que os serviços estejam estruturados e dimensionados para aplicação.
RECOMMENDATIONS FOR THE SELECTION OF STANDARD SIZES OF THE BODY AND IMPACT ELEMENTS OF THE GRINDING AND MIXING ROTARY PULSATION COMPLEX
Authors: Shcherbinina O. , Scherbinin I. , Uvarov V. , Popov E.
Published: August 2023

In this article, the main recommendations aimed at the optimal choice of body sizes and impact elements of the grinding and mixing rotary pulsation complex, taking into account the power consumption, were analyzed and given. These recommendations were aimed at solving design problems related to determining the dependencies of the size of the housing with its main technological parameters, with the possibility of using data in the design of these complexes. Calculations of a number of basic standard sizes of the complex have been made taking into account the ratios of the diameter and width of the complex, the dimensions of the working elements, their body area, the number of slots based on the following input values, productivity, power consumption and a parameter characterizing the efficiency of the complex – alternating pressure in the channels of the rotor and stator.

In the work, the power criteria calculated for the turbulent regime were determined. Graphical dependences of the total power costs of the complex on the rotational speed of the stator and rotor elements for a number of basic sizes of the complex are obtained. The housing of the complex was designed taking into account the accepted standard sizes. Taking into account the obtained values of the total power costs for each gap of the complex, the maximum radius of the rotor was determined. Taking into account the conditions of structural strength of the cylinder wall thickness of the complex, calculations were made for the diameters of the stator and rotor for a number of standard sizes of the complex. Based on these calculations, we selected the number of slots on the rotor and stator, their width and height