bluuebunny/crossref_metadata_2025 huggingface dataset:
Elite Mortuary Culture at Susa
Authors: Wicks Yasmina
Published: August 2024

A crucial task of archaeological research today is to comprehend and critically interpret the rich legacy from early excavations of ancient Near Eastern settlement sites. Yasmina Wicks explores the problematic and rarely consulted early 20th century records of excavations by French delegations at the UNESCO World Heritage-listed site of Susa in what is now southwest Iran. Through the study of published and unpublished documents, a new dataset of over 250 clay coffin burials, never before examined, is compiled, revealing a mortuary practice that began to flourish in the city at around 2000 BC. These coffins were not used as upright containers, but were turned upside down to cover the corpse, a distinctive method that is also documented in contemporary settlements in neighboring southern Mesopotamia. Elite Mortuary Culture at Susa begins with a discussion of the possibilities and limitations in the use of the legacy data, and then proceeds to an analysis of the typology, chronology, location distribution and frequency of the coffins. It then examines the rich and varied grave goods, the burial rites and the demographic profile associated with their use. It finishes by discussing the general significance of the inverted clay coffin and concludes that it can be seen as an essential feature of Susa’s bicultural society, offering a new perspective on the cultural links of Elamites and Mesopotamians as the city left the political embrace of Mesopotamia’s Ur III dynasties at the end of the Early Bronze Age and became the seat of the Elamite rulers from the Zagros Mountains in the lowlands. The mortuary behavior associated with the coffins, initially characterized by an unprecedented consumption of wealth, is interpreted as a response to new socio-political and socio-economic conditions both locally and across the Near East in the defining early years of the Middle Bronze Age.
Integrating supervised and reinforcement learning for predictive control with an unmodulated pyramid wavefront sensor for adaptive optics
Authors: Pou Bartomeu , Smith Jeffrey , Quinones Eduardo , Martin Mario , Gratadour Damien
Published: August 2024

We propose a novel control approach that combines offline supervised learning to address the challenges posed by non-linear phase reconstruction using unmodulated pyramid wavefront sensors (P-WFS) and online reinforcement learning for predictive control. The control approach uses a high-order P-WFS to drive a tip-tilt stage and a high-dimensional mirror concurrently. Simulation results demonstrate that our method outperforms traditional control techniques, showing significant improvements in performance under challenging conditions such as faint stars and poor seeing, and exhibits robustness against variations in atmospheric conditions.
Brillouin fiber laser for signal generation from microwave-to-terahertz regimes
Authors: Zhu Xiang , Huang Yali , He Tong , He Hongxia , Yu Xianbin
Published: August 2024

Flexible radio-frequency (RF) signal generation in a wide range is of great significance for the application of microwave photonics. In this work, we propose and experimentally demonstrate a dual-wavelength Brillouin fiber laser (BFL) that stably oscillates the stimulated Brillouin scattering (SBS) signals in an all-optical feedback cavity without any electro-optic or optoelectronic conversions. To effectively form the single mode, the two SBS lights outflowed from the cavity are put asunder and separately injected into their pump loop. By self-injected locking to the SBS signal rather than the laser pump as in the literature, single mode oscillation happens in the wideband of 14-300 GHz with a tunable frequency resolution of about 130 MHz. The phase noise is measured by down-converting the BFL via an optical frequency comb (OFC), which reaches below -98 dBc/Hz at 10-kHz offset frequency within 250 GHz, and -89.7 dBc/Hz@10kHz at 300 GHz, providing a widely tunable optical source for terahertz community.
High-precision angle error compensation method for a Dove prism scanning system based on galvanometers
Authors: Li Huaming , Wang Yu , Lu Junwen , Quan Tingwei , Liu Xiuli , Zeng Shaoqun , Lv Xiaohua
Published: August 2024

Dove prisms suffer from angle and shift errors due to inevitable errors in manufacturing and installation, limiting their applicability in tasks requiring high-precision scanning. These errors, particularly angle errors, can significantly deform and ruin the intended scanning trajectory. Here, we propose a method for compensating the angle errors in Dove prisms using galvanometers. The method first determines the angle error by analyzing the distorted scanning trajectory. Subsequently, by synchronizing the galvanometers with the Dove prism rotation, the galvanometers dynamically correct the angle error at each rotation angle. This approach eliminates the need for complex mechanical adjustment mechanisms and offers a convenient calibration process. Our experiments demonstrate that the angle error can be adjusted to be below 17 µrad under the described conditions. By enabling high-precision scanning, this method has the potential to broaden the application scenarios of Dove prisms in various fields.
Enhancements to quantum communication performance utilizing a prototype photonic lantern and multiplexed single-photon detection
Authors: Chandrasekharan Harikumar K. , Barrow Peter , MacLachlan David , Thomson Robert R. , Donaldson Ross
Published: August 2024

The optical interfacing between a free-space channel and single-photon detectors (SPDs) can greatly impact the inherent performance of a free-space quantum key distribution receiver. Direct coupling to detectors creates engineering challenges, and a single-mode fiber requires adaptive optics. Using a multimode fiber (MMF) is common; however, larger core diameters limit the achievable bandwidth. We demonstrate a prototype multimode fiber-based photonic lantern that allows us to retain the benefits of the large multimode coupling while transitioning to multiple, less multimodal fibers, reducing bandwidth limitation.
Polarization-independent quasi-BIC supported by non-rotationally symmetric dimer metasurfaces
Authors: Huang Zhisen , Wang Jin , Jia Wei , Zhou Changhe , Zhang Shanwen
Published: August 2024

Asymmetric metasurfaces supporting quasi-bound states in the continuum (-BICs) have recently attracted significant interest in the field of nanophotonics due to their high quality factor and strong light–matter interaction properties. However, asymmetric metasurface structures are susceptible to the polarization state of the incident light, which constrains their potential applications. In this Letter, we present a new, to our knowledge, scheme of polarization-independent quasi-BIC resonance supported by a non-rotationally symmetric nanorod dimer metasurface. By tuning the asymmetry parameter, the designed metasurface exhibits a consistent quasi-BIC response for incident plane waves of arbitrary polarization. The physical mechanism of the quasi-BIC resonance is elucidated by the study of the far-field multipole decomposition and the near-field electromagnetic distribution. We then point out that the realization of the polarization-independent quasi-BIC resonance depends on the transition between magnetic and electric quadrupoles. Furthermore, the designed metasurface is demonstrated to have excellent refractive index sensing performance. This work provides a new idea for the design of polarization-independent and high-performance resonators.
Forecasting risk and return of listed real estate:
Authors: Lausberg Carsten , Brandt Felix
Published: August 2024

In this paper a forecasting model for real estate stock returns and risks is developed and tested with the data of German real estate companies from 1991 to 2021. In contrast to several other studies, alternative risk measures are used to adequately reflect investors’ preferences. At first, the paper constructs a traditional five-factor Arbitrage Pricing Theory model to measure the sensitivity of real estate stock returns to the stock, bond and real estate markets as well as to inflation and the overall economy. The analysis shows that German real estate stocks have a high idiosyncratic risk and that they are more impacted by changes in the economy and the stock market than by changes in the real estate market. Then a geometric Brownian motion concept combined with a Monte Carlo simulation is applied to model future asset prices. The downside risk measures value at risk and conditional value at risk are used to quantify the risk for an investor in listed real estate instead of the usual volatility. The paper finds that listed real estate has less downside risk than general stocks.
Actomyosin-mediated apical constriction promotes physiological germ cell death in C. elegans
Authors: Kohlbrenner Tea , Berger Simon , Laranjeira Ana Cristina , Aegerter-Wilmsen Tinri , Comi Laura Filomena , deMello Andrew , Hajnal Alex
Published: August 2024

Germ cell apoptosis in Caenorhabditis elegans hermaphrodites is a physiological process eliminating around 60% of all cells in meiotic prophase to maintain tissue homeostasis. In contrast to programmed cell death in the C. elegans soma, the selection of germ cells undergoing apoptosis is stochastic. By live-tracking individual germ cells at the pachytene stage, we found that germ cells smaller than their neighbors are selectively eliminated through apoptosis before differentiating into oocytes. Thus, cell size is a strong predictor of physiological germ cell death. The RAS/MAPK and ECT/RHO/ROCK pathways together regulate germ cell size by controlling actomyosin constriction at the apical rachis bridges, which are cellular openings connecting the syncytial germ cells to a shared cytoplasmic core. Enhancing apical constriction reduces germ cell size and increases the rate of cell death while inhibiting the actomyosin network in the germ cells prevents their death. We propose that actomyosin contractility at the rachis bridges of the syncytial germ cells amplifies intrinsic disparities in cell size. Through this mechanism, the animals can adjust the balance between physiological germ cell death and oocyte differentiation.
Metabolic specialization drives reduced pathogenicity in Pseudomonas aeruginosa isolates from cystic fibrosis patients
Authors: Pedersen Bjarke Haldrup , Simões Filipa Bica , Pogrebnyakov Ivan , Welch Martin , Johansen Helle Krogh , Molin Søren , La Rosa Ruggero
Published: August 2024

Metabolism provides the foundation for all cellular functions. During persistent infections, in adapted pathogenic bacteria metabolism functions radically differently compared with more naïve strains. Whether this is simply a necessary accommodation to the persistence phenotype or if metabolism plays a direct role in achieving persistence in the host is still unclear. Here, we characterize a convergent shift in metabolic function(s) linked with the persistence phenotype during Pseudomonas aeruginosa colonization in the airways of people with cystic fibrosis. We show that clinically relevant mutations in the key metabolic enzyme, pyruvate dehydrogenase, lead to a host-specialized metabolism together with a lower virulence and immune response recruitment. These changes in infection phenotype are mediated by impaired type III secretion system activity and by secretion of the antioxidant metabolite, pyruvate, respectively. Our results show how metabolic adaptations directly impinge on persistence and pathogenicity in this organism.
Pervasive tissue-, genetic background-, and allele-specific gene expression effects in Drosophila melanogaster
Authors: Glaser-Schmitt Amanda , Lemoine Marion , Kaltenpoth Martin , Parsch John
Published: August 2024

The pervasiveness of gene expression variation and its contribution to phenotypic variation and evolution is well known. This gene expression variation is context dependent, with differences in regulatory architecture often associated with intrinsic and environmental factors, and is modulated by regulatory elements that can act in cis (linked) or in trans (unlinked) relative to the genes they affect. So far, little is known about how this genetic variation affects the evolution of regulatory architecture among closely related tissues during population divergence. To address this question, we analyzed gene expression in the midgut, hindgut, and Malpighian tubule as well as microbiome composition in the two gut tissues in four Drosophila melanogaster strains and their F1 hybrids from two divergent populations: one from the derived, European range and one from the ancestral, African range. In both the transcriptome and microbiome data, we detected extensive tissue- and genetic background-specific effects, including effects of genetic background on overall tissue specificity. Tissue-specific effects were typically stronger than genetic background-specific effects, although the two gut tissues were not more similar to each other than to the Malpighian tubules. An examination of allele specific expression revealed that, while both cis and trans effects were more tissue-specific in genes expressed differentially between populations than genes with conserved expression, trans effects were more tissue-specific than cis effects. Despite there being highly variable regulatory architecture, this observation was robust across tissues and genetic backgrounds, suggesting that the expression of trans variation can be spatially fine-tuned as well as or better than cis variation during population divergence and yielding new insights into cis and trans regulatory evolution.
Nutrition and diet in the general U.S. Asian American population: A scoping review protocol
Authors: Chan Sze Wan , Laynor Gregory , Ali Shahmir H. , Yi Stella S.
Published: August 2024

Introduction

Asian American populations face unique structural/social inequities contributing to poor diet quality and health disparities. The current body of literature on diet and food consumption of Asian Americans mainly focuses on the health of Filipino and East Asian Americans, or those with pre-existing non-communicable diseases.

Objective

The aim of this review is to comprehensively compile all available literature on nutrition and dietary consumption among the general population in Asian American ethnic subgroups, highlight any disparities and research gaps, and suggest further research action.

Methods

With guidance from a research librarian, we enumerated and searched key terms related to diet, food, nutrition, and Asian Americans in PubMed/MEDLINE, Food Science Collection (CABI Digital Library), CINAHL (EBSCO), Scopus, Food Science and Technology Abstracts (Web of Science), and Biological & Agricultural Index Plus (EBSCO) in accordance with PRISMA-S guidelines. An article will be included if it was published in the English language; is a peer-reviewed research manuscript or published in grey literature from 2000 to present; and describes what food groups and macronutrients healthy non-institutionalized Asian Americans in the U.S. are eating. An article will be excluded if it contains only research conducted outside of the U.S.; combines Asian Americans with Native Hawaiian and Pacific Islanders; and had no explicit focus on Asian American nutrition and dietary consumption. Two or more reviewers will participate in the study screening and selection process. We will record article characteristics, diet outcomes, and recommendations from final included articles using a data extraction table and prepare a summary narrative with key findings.

Expected outputs

Results will be disseminated through a peer-reviewed manuscript. The findings from this review can have broad implications for designing and implementing nutrition-focused initiatives that will appropriately reflect and address the needs as well as norms and values of each distinct Asian American ethnic subgroup.
Women, Ageing and the Screen Industries: Falling Off a Cliff?, Susan Liddy (ed.) (2023)
Authors: Lowry LeeAnne
Published: August 2024

Review of: Women, Ageing and the Screen Industries: Falling Off a Cliff?, Susan Liddy (ed.) (2023)

Cham: Springer International Publishing AG, 247 pp.,

ISBN 978-3-03118-385-0, e-book, USD 109.00
Editorial
Authors: Mittermeier Sabrina
Published: August 2024

The Apple TV+ series Ted Lasso (2020–23) came at a time of both the COVID-19 pandemic and the era of ‘Peak TV’ and ‘streaming wars’, both shaping its critical reception and lasting its impact beyond those times. This Special Issue of the Journal of Popular Television (JPTV) delves into central issues interrogated in the series, such as masculinity, mental health, race and racism, sportswashing and the English Premier League, as well as the series’ fandom and use of intertextuality.
¿Brasil está pasando por un proceso de desindustrialización?
Authors: Esteban Do V. Jardim Paula , Steiner Perin Fernanda
Published: August 2024

La discusión sobre si Brasil está pasando, o no, por un proceso de desindustrialización está presente en la agenda económica actual. El presente artículo tiene como objetivo profundizar el debate sobre el proceso de desindustrialización en Brasil, considerando que los indicios sobre el futuro de la estructura industrial brasileña apuntan a un escenario complejo y sin respuestas fáciles. De esa manera, inicialmente se analizan las causas del proceso de desindustrialización y sus impactos en el país. También son analizados datos e indicadores que contemplan las diferentes categorías industriales brasileñas a partir de la segunda mitad de la década de los 90 y se pone en evidencia que el país pasa por una desindustrialización precoz y no generalizada, aunque de carácter restrictivo para su desarrollo económico.
Aproximación histórica a las coproducciones hispano-brasileñas
Authors: Gómez Pérez Francisco Javier , Pérez Rufí José Patricio
Published: August 2024

Las autoridades de España y Brasil firmaron un primer acuerdo de coproducción cinematográfica en 1963. Este no se modificó hasta 2008, cuando el ICAA y ANCINE ratificaron un nuevo convenio bilateral. Además, ambos países pertenecen a la CACI, promotora de diferentes acuerdos y convenios para estimular la construcción de un espacio audiovisual iberoamericano, cuyo principal exponente es el programa IBERMEDIA. Fruto de estos acuerdos, bilaterales o multilaterales, son una serie de producciones hispano-brasileñas que el presente trabajo pretende compilar para demostrar la eficacia de las políticas de apoyo a la coproducción cinematográfica.
Breves consideraciones sobre las relaciones comerciales entre Brasil y España
Authors: Espíndola Carlos José , Marthins De Araujo Junior Aloysio
Published: August 2024

Este texto trata de las relaciones comerciales entre Brasil y España en los últimos años. España tiene un importante volumen de exportaciones a Brasil de productos manufacturados de mayor valor añadido. Por su parte las exportaciones brasileñas a España son, básicamente, de materias primas y de productos relacionados con la agroindustria que añaden valor técnico a la cadena de producción y no al producto final, como en el caso del complejo de la soja. La liberalización del comercio emprendida por Brasil desde la década de 1990 trajo cambios importantes (negativos) para la industria brasileña, reduciendo la participación en el PIB y en el comercio exterior. Por otra parte, la entrada de España en la Unión Europea a finales de la década de 1980 trajo inicialmente grandes inversiones que permitieron la modernización de su parque industrial, cuyos beneficios en relación a Brasil, ahora se hacen sentir. Por lo tanto, el artículo intenta dar una visión general de las relaciones comerciales entre ambos países, concluyendo que Brasil aún permanece en la situación del país de exportación agrícola, reforzando su sumisión a la tradicional División Internacional del Trabajo.
Vector abundance and associated abiotic factors that influence the distribution of ticks in six provinces of South Africa
Authors: Makwarela Tsireledzo G. , Djikeng Appolinaire , Masebe Tracy M. , Nkululeko Nyangiwe , Nesengani Lucky T. , Mapholi Ntanganedzeni O.
Published: August 2024

Background and Aim: Climatic conditions significantly impact the life stages and distribution patterns of ticks and tick-borne diseases. South Africa’s central plateau and various biomes offer a distinct landscape for studying the geography’s effects. The study estimated tick species prevalence and the influential factors on their survival.

Materials and Methods: Ticks were gathered from communal cattle in South African provinces including Limpopo (LP), Gauteng (GP), Mpumalanga (MP), KwaZulu-Natal (KZN), the Eastern Cape (EC), and the Free State (FS), from September 2020 to November 2022. Using data from South African weathercasts, the annual climate was assessed.

Results: A total of 3,409 ticks were collected, with the highest infestation observed in KZN (45%), followed by LP (26%), EC (19%), GP (5%), MP (2%), and the FS (2%). The most prevalent tick species were Amblyomma hebraeum (55.1%), Rhipicephalus evertsi evertsi (13.9%) and Rhipicephalus (Boophilus), and decoloratus (11.9%). Other species included R. (Boophilus) microplus (10.85%), Hyalomma marginatum (4.8%), Rhipicephalus appendiculatus (1.4%), Harpalus rufipes (0.8%), Rhipicephalus exophthalmos (0.2%), Rhipicephalus glabroscutatus (0.2%), Rhipicephalus sanguineus (0.2%), Haemaphysalis silacea (0.5%), Ixodes pilosus (0.1%), and Rhipicephalus simus (0.1%). The infestations were most prevalent on farms in Pongola and KZN. The temperature fluctuated between 12°C and 35°C during data gathering, while humidity varied between 40% and 65%.

Conclusion: This study showed that ticks survive optimally in warm temperatures and high humidity conditions. Livestock farms with high tick infestations may be associated with several risk factors. These practices could involve suboptimal grazing, insufficient acaricidal treatment, and detrimental effects resulting from traditional animal husbandry. Future research is needed to longitudinally evaluate the effects of climate change on tick populations, pathogen transmission, hosts, habitats, and human behavior, influencing potential exposure risks.

Keywords: abiotic factors, cattle infestations, climatic conditions, South Africa, ticks, vector abundance.
Molecular typing methods to characterize Brucella spp. from animals: A review
Authors: Daugaliyeva Aida , Daugaliyeva Saule , Kydyr Nazerke , Peletto Simone
Published: August 2024

Brucellosis is an infectious disease of animals that can infect humans. The disease causes significant economic losses and threatens human health. A timely and accurate disease diagnosis plays a vital role in the identification of brucellosis. In addition to traditional diagnostic methods, molecular methods allow diagnosis and typing of the causative agent of brucellosis. This review will discuss various methods, such as Bruce-lаdder, Suiladder, high-resolution melt analysis, restriction fragment length polymorphism, multilocus sequence typing, multilocus variable-number tandem repeat analysis, and whole-genome sequencing single-nucleotide polymorphism, for the molecular typing of Brucella and discuss their advantages and disadvantages.

Keywords: Brucella, molecular typing, multilocus sequence typing, multilocus variable-number tandem-repeat analysis, single-nucleotide polymorphisms, whole-genome sequencing.
Fényképek és rajzok figyelemterelő szerepe egy norvég önéletrajzi képregényben
Authors: Domsa Zsófia
Published: August 2024

A képregényekben szereplő fényképek évtizedek óta a képregénykutatás homlokterében állnak. A fényképek rajzolt közeghez képest eltérő medialitása és a valósággal való szorosabb viszonya kihat arra, ahogy a fotókat magukba foglaló képregények egészét értelmezzük. Tanulmányomban azt vizsgálom, ahogy a norvég Steffen Kverneland En frivillig død [Önkéntes halál, 2018] önéletrajzi képregényében megjelenő családi fényképek a grafikus narratíva eszközeként az ábrázolt helyzetek mentális beágyazottsági szintjeinek növelését eredményezik. Kverneland memoárjának központjában az öngyilkosságot elkövető apa portréja áll. A képregény a családi fotóalbum keretét használja, amelyben a képek átjárást biztosítanak a diegetikus és extradiegetikus világ, a jelenbeli narráló én és a múltat megtapasztaló én gondolatvilága, a történetmesélés személyes és közösségi szintje között. A fényképek a valóság egy szeletét rögzítik, ám az elbeszélés hitelességét igazán azzal bizonyítják, hogy átrajzolt változataikkal együtt az emberi emlékezet képlékenységét ábrázoló mű dinamikus elemeivé válnak. A fénykép-rajz transzformáció miatt kialakuló szaliencia három példáján keresztül mutatom be, hogy a szöveges elemek, fényképek és rajzolt változataik hogyan terelik az olvasó figyelmét a képek elsődleges funkciójáról az öngyilkosság gondolati hátterének és a hozzátartozók gyászmunkájának szociokognitív összetettségére. Tanulmányom távolabbi célja, hogy hozzájáruljon a magyar képregénykutatáshoz azáltal, hogy felhívja a figyelmet erre a kiemelkedő norvég grafikus regényre, amely az északi országok gazdag képregényirodalmát kiválóan reprezentálja.
A nagy sövényen túl
Authors: Benyovszky Krisztián
Published: August 2024

A tanulmány a szószerinti és a figuratív jelentés közötti dinamikát vizsgálja Ursula K. Le Guin A vadorzó (The Poacher) című novellájában, mely a Csipkerózsika kiegészítő átirata. Azt kívánja bemutatni, hogyan, milyen elbeszélői stratégiáknak és retorikai alakzatoknak köszönhetően távolít el minket rendre a szöveg a szószerintiségnek a szintjétől, azt a benyomást keltve, hogy itt többről is van szó. A tárgyi és természeti környezet elemei, illetve a dinamikus, cselekményképző motívumok ugyanis valami másnak a jelévé alakulnak át. Le Guin úgy írja újra a klasszikus mesét, hogy közben magát ezt a tevékenységet – az idegen szövegvilágba való behatolás és annak rendjébe való beavatkozás műveletsorát allegorizálja; nem tolakodó didaktikussággal, hanem visszafogottan, a történetből szervesen kibomló módon. A vadorzó alakja és aktivitása az újraírás felől nézve nyeri el rejtett jelentését. Ez a „kettős hangzás” az olvasó figyelemének megosztásához, a két jelentésszint közötti folyamatos oszcillációhoz vezet, és a belemerülő olvasás kizökkentésével jár együtt.  A tanulmány ezt a jelenséget narratológiai, retorikai, szemiotikai és kognitív poétikai vizsgálódási szempontok bevonásával igyekszik közelebbről megvilágítani.
Exploring Public Perception of Pharmacovigilance: Insights from a Social Media Survey
Authors: Zacharie Amélie , Mueller Marion
Published: August 2024

This study explored global perspectives on pharmacovigilance (PV) through a social media survey. Findings revealed significant opportunities to enhance public awareness and engagement in drug safety initiatives. The research underscores the critical importance of increasing transparency in PV practices as well as improving public understanding of PV and emerging technologies to ultimately enhance drug safety initiatives and foster collective responsibility in adverse event reporting.
Uso de antioxidantes naturais em queijo Minas frescal - Revisão
Authors: Da Silva Tatiana Labre , Gouvêa Fernanda De Jorge
Published: August 2024

O queijo Minas Frescal é relevante fonte nutricional na dieta, e seu consumo é expressivo e crescente. Entretanto, os ácidos graxos insaturados e colesterol presentes em sua fração lipídica são suscetíveis à oxidação, com implicações em questões de saúde devido a perdas na qualidade e formação de compostos nocivos aos consumidores. Em virtude da importância dos lácteos, associado à valorização da qualidade alimentar em consonância com práticas limpas de produção, destaca-se a importância da fração lipídica, com identificação da composição de ácidos graxos e teor de colesterol. A indústria de alimentos utiliza várias estratégias para o uso dos antioxidantes a fim de reduzir a oxidação lipídica e aumentar o prazo de validade. As ervas e especiarias são ingredientes naturais que têm sido amplamente utilizadas não apenas como aromatizante de alimentos, mas também por seus atributos de saúde. O presente estudo trata-se de uma revisão de literatura sobre a composição lipídica do queijo Minas Frescal e o uso de aditivos naturais para a proteção à oxidação lipídica. Assim, o uso de fontes vegetais no queijo Minas Frescal, além de conferir sabor, aroma e cor, são opções de conservantes naturais em substituição aos aditivos sintéticos, com presença de compostos antioxidantes, antimicrobianos e anticancerígenos, com potencial proteção às reações indesejáveis, atendendo à demanda dos consumidores por alimentos saudáveis.
Boerhaave Syndrome Mimicking Acute Coronary Syndrome
Authors: Schalet Reid , Carro Cruz Francis , Berezowski Ivan , Adams-Mardi Cyrus , Haile Hanna , Schueler Samuel A. , Borum Marie L.
Published: August 2024

Boerhaave syndrome, an esophageal perforation due to increased intraesophageal pressure, may mimic other cardiovascular conditions including acute coronary syndrome. In this report, we present a case of a 63-year-old man who presented with chest pain and ischemic electrocardiogram abnormalities, prompting an initial diagnosis of ST elevation myocardial infarction. After coronary stenting, the patient continued to have chest pain, ST segment elevations, and newly elevated cardiac enzymes. A computed tomography scan showed esophageal perforation, requiring endoscopic stenting. This case underscores the diagnostic and therapeutic challenges of Boerhaave syndrome and the importance of considering this condition in adults with chest pain and ischemic electrocardiogram changes.
Upper Gastrointestinal Bleeding Due to Metastatic Lung Adenocarcinoma in the Stomach and Duodenum
Authors: Arif Taha Bin , Alabbas Bedoor , Vinayek Rakesh
Published: August 2024

There are very few reports of bloodborne metastasis of lung adenocarcinoma to the gastrointestinal tract, primarily due to poor prognosis and short survival rate of metastasized carcinoma. We present a case of a 79-year-old man with a medical history of lung adenocarcinoma, who presented with complaints of weakness and melena for 1 week. He had symptomatic anemia, for which he was transfused with blood. Esophagogastroduodenoscopy showed a 10 mm sessile polyp in the gastric body that was removed. One month later, the patient presented with a similar complaint, and another esophagogastroduodenoscopy revealed 2 ulcerated lesions in the second portion of the duodenum. These lesions were treated by hemostatic clip placement and heater probe coagulation. Biopsy of lesions demonstrated thyroid transcription factor 1 and Napsin-positive tumor cells, consistent with lung adenocarcinoma. Owing to the poor prognosis of lung adenocarcinoma metastasizing to the lymph nodes, stomach, and duodenum, the patient was transferred to hospice care.
Querer, poder y fortuna en el Encomio de Helena de Gorgias
Authors: Bieda Esteban Enrique
Published: August 2024

El Encomio de Helena (EH) de Gorgias tiene como objetivo relevar todas las causas posibles que podrían haber llevado a Helena a viajar junto con Alejandro hacia Troya. Dado que la intención de Gorgias es eximir a Helena de responsabilidad, el texto recorre minuciosamente cada uno de los motivos que pudieron haber provocado el viaje. En el presente trabajo intentaré mostrar que, prestando atención a estas distintas alternativas, es posible ver, en primer lugar, que en todos los casos se trata de instancias eminentemente externas a Helena, es decir, de causas que le vienen desde afuera y que inciden en su curso de acción. No obstante, en segundo lugar, mostraré que la enumeración de estas causas describe cierta parábola que va desde la exterioridad absoluta (Fortuna, dioses, Necesidad) hasta una exterioridad que se interna en el alma humana: el amor (éros). Visto esto, concluiré que en el EH Gorgias insinúa la distinción entre causas externas e internas del obrar humano, distinción que será fundamental para la filosofía práctica posterior.
La dialéctica como caja de herramientas
Authors: Álvarez Lucas Manuel
Published: August 2024

Cuestionado el protagonismo que han acaparado los procedimientos de división y reunión en los estudios sobre la dialéctica del Platón tardío, nos proponemos echar luz sobre una herramienta que, funcionando a la par de aquellos, ha sido soslayada. Nos referimos a la metretiké y al rol clave que ella cumple en los diálogos Político y Filebo. Además, partiendo de ese estudio, sugeriremos que el método filosófico ideal opera como un variado kit de herramientas sin circunscribirse a ninguna de ellas.
Динамика теплового перепутывания в нерезонансной трехкубитной модели Тависа-Каммингса с керровской нелинейностью
Authors: Bagrov Aleksandr Romanovich , Bashkirov Evgenii Konstantinovich
Published: August 2024

Рассматривается динамика трех идентичных кубитов, нерезонансно взаимодействующих с тепловым полем идеального резонатора со средой Керра. Найдены решения квантового временного уравнения Лиувилля для полной матрицы плотности системы из трех кубитов и поля резонатора для начальных сепарабельных, бисепарабельных и истинных перепутанных состояний кубитов и теплового начального состояния поля резонатора. Путем усреднения полной матрицы плотности по переменным поля резонатора и по переменным одного из кубитов найдена редуцированная матрица плотности пары оставшихся кубитов.
Проведены вычисления для всех возможных пар кубитов.
Двухкубитные матрицы плотности использованы для вычисления параметра перепутывания кубитов - отрицательности пар кубитов. Проведено численное моделирование временной зависимости отрицательности для различных начальных состояний кубитов и параметров модели.
Результаты численного моделирования отрицательности пар кубитов показали, что наличие расстройки и керровской нелинейности в случае начального сепарабельного состояния пары кубитов может приводить к существенному увеличению степени их перепутывания.
В случае начального перепутанного состояния пары кубитов расстройка и керровская среда могут значительно уменьшить амплитуды осцилляций Раби отрицательности и, соответственно, приводить к существенной стабилизации начального перепутывания кубитов.
Показано также, что наличие расстройки и керровской нелинейности может приводить к исчезновению эффекта мгновенной смерти перепутывания кубитов.
Численный метод структурной и параметрической идентификации математической модели неполной обратимости деформации ползучести
Authors: Radchenko Vladimir Pavlovich , Zoteev Vladimir Eugenievich , Afanaseva Elena Andreevna
Published: August 2024

Разработан новый численный метод параметрической и структурной идентификации физически нелинейной теории обратимости деформации ползучести, справедливой в пределах первой и второй стадий. В качестве базовой экспериментальной информации используется серия кривых стационарной ползучести. Задача сведена к нелинейному регрессионному анализу определения оценок случайных параметров на основе временных рядов последовательности результатов наблюдений деформации ползучести при различных постоянных напряжениях с использованием разностных уравнений. Полученные соотношения между коэффициентами разностного уравнения и параметрами нелинейной регрессии позволяют свести задачу к оценке коэффициентов линейно-параметрической дискретной модели. Разработаны соответствующие итерационные алгоритмы уточнения оценок параметров с любой заданной точностью. Выполнена параметрическая и структурная идентификация теории неполной обратимости деформации ползучести для стали ЭИ736 (500 $^\circ$C) и сплавов ЭИ437А (700 $^\circ$C), ВЖ98 (900 $^\circ$C), ЭП693 (700 $^\circ$C). Приводятся численные значения оценок параметров моделей для этих сплавов. Выполнена проверка адекватности построенных математических моделей, наблюдается соответствие расчетных и экспериментальных данных. Экспериментальные данные для всех рассмотренных материалов принадлежат соответствующим расчетным доверительным интервалам для деформации ползучести, что свидетельствует о достоверности полученных оценок параметров моделей.
Transmission Power Reduction Based on an Enhanced Particle Swarm Optimization Algorithm in Wireless Sensor Network for Internet of Things
Authors: Lilo Moneer A. , Yasari Abidulkarim K. , Hamdi Mustafa M. , Abbas Abdulkareem D.
Published: August 2024

A wireless sensor network (WSN) consists of several sensor nodes; all these nodes can sense physical events, including light, heat, and pressure. These networks are essential in smart homes, smart agriculture, and smart water management, swelling with the concept of the Internet of Things. However, WSN needs to address the challenges of energy issues; thus, energy-conserving techniques have been pursued for communication. Optimization of energy is normally solved using the Particle Swarm Optimization (PSO) algorithm since it offers high accuracy but is prone to local optima, thus resulting in early convergence. To tackle this challenge, this paper proposes the development of an enhanced particle swarm optimization for the node power estimation (EPSO-NPE) model. EPSO-NPE calculates distinct transmission powers for each node, preventing the formation of isolated areas within a sensor cluster. Unlike the original PSO, the EPSO algorithm enhances exploration capabilities by avoiding stagnation on search space boundaries. A comparative analysis with the original PSO-based model (PSO-NPE), where nodes adopt maximum power for connectivity, reveals superior performance by EPSO-NPE. The enhanced model exhibits heightened energy-saving capabilities, ultimately extending the network’s lifetime.
Population dynamic of mackerel scad (Decapterus macarellus Cuvier, 1833) in the Timor Sea
Authors: Herwaty Susy , Mallawa Achmar , Najamuddin Najamuddin , Zainuddin Mukti
Published: August 2024

Mackerel scad (Decapterus macarellus) is a fish resource that contributes to the economic sector for fishermen in the province of East Nusa Tenggara province. Its production has increased every year. This study aims to analyze the parameters of the population dynamics of the mackerel scad. Fish samples were collected at the Oeba Fish Landing Base Kupang from April to June 2020. The data analysis used included size structure analyzed descriptively, age group using the Bhattacharya method, growth parameter values (L∞ and K) based on the von Bertalanffy equation, natural mortality using the Pauly method, and Y/R using the Beverton and Holt method. The results showed that the smallest size of the mackerel scad was 7.8 cm (FL), the largest size was 27.8 cm (FL), the average length was 19.63 cm (FL) ± 4.46, the asymptotic length (L∞) = 38.10 cm (FL), the growth parameter value (K)= 0.51 year-1, t0= -0.2996 year-1, The population consists of two to three age groups.  the total mortality value (Z)= 2.29 year-1, natural mortality (M) = 1.08 year-1, fishing mortality (F)= 1.22 year-1 and  exploitation rate (E)= 0.53 year-1. The actual Y/R value was 0.057 and the relative Y/R was 0.060 grams recruit-1
Bioaccumulation of Lead (Pb) on The Dog Conch (Strombus canarium) in Madong Waters, Tanjung Pinang
Authors: Tirtama Wahyu , Bengen Dietriech Geoffrey , Rastina Rastina
Published: August 2024

The waters of Madong in Tanjung Pinang city are located in a strategic area that has a significant impact on the livelihoods of fishermen, post-bauxite mining areas, ship traffic, and population activities. These factors have contributed to the contamination of heavy metal Pb in the waters, sediments, and dog conch. The purpose of this study is to analyze the levels of heavy metal Pb in the waters, sediment, and dog conch, and to assess the bioaccumulation factors of heavy metal Pb in dog conch in Madong waters. Samples of waters, sediment, and dog conch were collected from three stations and analyzed using AAS at the Marine Chemistry Laboratory of Raja Ali Haji Maritime University. The concentration of Pb in the waters ranged from 0.0204 mg/L to 0.0636 mg/L, while the concentration of Pb in sediment ranged from 0.5947 mg/Kg to 0.9402 mg/Kg. The Pb metal concentration in juvenile dog conch ranged from 0.0745 mg/Kg to 0.3437 mg/Kg. The highest BAF and BSAF values for Pb metal in adult dog conch were observed at station 1, with values of 27.241 and 0.6991, respectively. The categorization of Pb metal in Strombus canarium dog conch as low is based on the BAF and BSAF value categories.
Aktivitas Antioksidan Ekstrak Astaxanthin dari Limbah Kulit dan Kepala Udang Dogol (Metapenaeus ensis)
Authors: Rahmalia Winda , Adhitiyawarman Adhitiyawarman , Prayitno Dwi Imam , Lubis Yosef Novem Batistuta
Published: August 2024

Astaxanthin is a carotenoid derivative compound with various benefits, one of which is as an antioxidant, making astaxanthin applicable in drugs and cosmetics. Astaxanthin is discoverable in various sources, with shrimp as its main source. This study aims to determine the antioxidant activity of astaxanthin extracted from shrimp shell and head wastes. Extraction was carried out using the soxhletation method, followed by saponification to obtain free astaxanthin. Astaxanthin in extract before and after saponification were identified using thin-layer chromatography (TLC) and UV-Vis spectrophotometry. Antioxidant activity assay was carried out in five variations of sample concentrations using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Extraction of shrimp shell and head wastes resulted in an oil yield percentage of 1.02 and 3.05 % of dry mass in 60 g of shrimp shells, respectively. Identification results showed astaxanthin content in extracts after saponification were higher than that before saponification. There are three thin layer chromatography (TLC) separation spots and two UV-Vis absorption peaks in extracts before and after saponification. Antioxidant activity assay results (IC50) of shrimp shell extract before and after saponification showed antioxidant activity of 572.0 and 186.6 mg/L, respectively. Astaxanthin merupakan senyawa turunan karotenoid dengan beragam manfaat, salah satunya sebagai antioksidan, sehingga membuat astaxanthin dapat diaplikasikan dalam obat-obatan dan kosmetik. Astaxanthin dapat ditemukan dalam berbagai sumber, dengan sumber utama adalah udang. Penelitian ini bertujuan untuk menentukan aktivitas antioksidan astaxanthin yang diekstraksi dari limbah kulit dan kepala udang. Ekstraksi dilakukan dengan metode soxhletasi, dilanjutkan dengan saponifikasi untuk mendapatkan astaxanthin bebas. Hasil ekstraksi dan saponifikasi diidentifikasi astaxanthinnya menggunakan kromatografi lapis tipis (KLT) dan spektrofotometri UV-Vis. Uji aktivitas antioksidan dilakukan pada lima variasi konsentrasi sampel menggunakan metode 2,2-difenil-1-pikrilhidrazil (DPPH). Ekstraksi limbah kulit dan kepala udang menghasilkan rendemen masing-masing sebesar 3,05 dan 1,02% massa kering dari 60 g kulit udang. Hasil identifikasi menunjukkan kadar astaxanthin dari ekstrak setelah saponifikasi lebih tinggi daripada sebelum saponifikasi. Terdapat tiga spot pemisahan kromatografi lapis tipis (KLT) serta dua puncak serapan UV-Vis pada ekstrak sebelum dan setelah saponifikasi. Hasil uji aktivitas antioksidan (IC50) kulit udang sebelum dan setelah saponifikasi masing-masing adalah 572,000 dan 186,583 mg/L.
PAR2 Knock-Out C57Bl6 Mice as a Model for Evaluating Metastases of Cancer Cells: Pilot in Vivo Study of the Metastatic Potential of B16 Melanoma in Knock-Out (PAR2-/-) Animals
Authors: Matěj Radoslav , Zadinová M. , Poučková P. , Kukal J. , Olejár T.
Published: August 2024

Proteinase-activated receptor 2 (PAR-2) is a ubiquitous surface molecule. It belongs to the family of G protein-coupled receptors activated by sitespecific proteolysis by trypsin. Altered function of PAR-2 has been described in different malignant tumours, both in vivo and in vitro. In the present study, we investigated differences of metastatic spread of B16 melanoma in knock-out animals compared with C57Bl6 mice. Knock-out mice B6.Cg-F2rl1tm1Mslb/J (PAR2-/-) and C57Bl6 controls were subcutaneously inoculated with the B16 melanoma tissue cell line. Fourteen days after inoculation, all primary tumours were removed and histopathologically analysed. After one month, animals in both group started to die. Autopsy showed metastatic spread of the melanoma to various organs in both groups. Our experiment confirmed growth and metastatic spread in both groups of mice. Excised tumours differed in volume and weight; average weight (0.62 g in PAR2-/and 0.4 g in control animals). Metastatic spread was observed in both groups and reached 80 % in PAR2-/and 50 % in control animals. While in control mice only lung metastases were observed, local tumour recurrence, renal and lung metastases were observed in PAR2-/mice. The absence of functional PAR-2 could be an important factor influencing the growth and spread of melanoma in vivo, probably associated with tumour cell migration, invasiveness and metastasis formation.
Ketone monoester plus high‐dose glucose supplementation before exercise does not affect immediate post‐exercise erythropoietin concentrations versus glucose alone
Authors: Howard Emily E. , Allen Jillian T. , McNiff Julie L. , Small Stephanie D. , O'Fallon Kevin S. , Margolis Lee M.
Published: August 2024

The objective of this study was to examine the effect of consuming ketone monoester plus a high dose of carbohydrate from glucose (KE + CHO) on the change in erythropoietin (EPO) concentrations during load carriage exercise compared with carbohydrate (CHO) alone. Using a randomized, crossover design, 12 males consumed KE + CHO (573 mg KE/kg body mass, 110 g glucose) or CHO (110 g glucose) 30 min before 4 miles of self‐paced treadmill exercise (KE + CHO:51 ± 13%, CHO: 52 ± 12% V̇O2peak) wearing a weighted vest (30% body mass; 25 ± 3 kg). Blood samples for analysis were obtained under resting fasted conditions before (Baseline) consuming the KE + CHO or CHO supplement and immediately after exercise (Post). βHB increased (p < 0.05) from Baseline to Post in KE + CHO, with no change in CHO. Glucose and glycerol increased (p < 0.05) from Baseline to Post in CHO, with no effect of time in KE + CHO. Insulin and lactate increased (p < 0.05) from Baseline to Post independent of treatment. EPO increased (p < 0.05) from Baseline to Post in KE + CHO and CHO with no difference between treatments. Although KE + CHO altered βHB, glucose, and glycerol concentrations, results from this study suggest that KE + CHO supplementation before load carriage exercise does not enhance immediate post‐exercise increases in EPO compared with CHO alone.
Effectuation, Causation and Bricolage; Entrepreneurial Orientation in the Face of Crisis, a Perspective from Developing Countries
Authors: Sunguh Kenneth Khavwandiza , Yi Xu
Published: August 2024

While previous studies on individual entrepreneurial orientation have evolved more from environmental, social and cultural features, far less attention has been dedicated to personal agency factors, especially during the crisis period of post COVID-19 pandemic. Relying on personal agency theory and the entrepreneurial cognitive logic concept, this study investigates how entrepreneur’s internal locus of control affect their individual entrepreneurial orientation, particularly during periods of crisis and scarcity-post COVID-19 pandemic. Data were collected from 500 small and medium scale entrepreneurs via an online questionnaire and analyzed using partial least square (PLS-SEM) methodology. The findings show that causation, bricolage and effectuation’s affordable loss and flexibility, which are most responsive to internal locus of control, significantly impact individual entrepreneurial orientation. However, no evidence has been found on how gender, education level and education background impacts the internal locus of control to promote entrepreneurial orientation. Finally, the paper highlights the relevance of considering personal agency factors, namely internal locus of control, for policy makers, especially those involved in institutions of learning and government ministries, to boost citizens perceptions and entrepreneurial orientation and behaviour particularly in developing countries.