bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALYTICAL STUDY OF SALIVARY MMP-12 EXPRESSION IN ORAL SUBMUCOUS FIBROSIS
Authors: Saleem Zohra , Shaikh Abdul Hafeez , Majeed Muhammad Mansoor , Ahmed Shaheen , Zaman Uzma , Siddiqui Zarah , Kazmi Anum
Published: April 2022

Background: Oral submucous fibrosis (OSF) is majorly a pathology pertaining to Asian population, reported most in Pakistan, India, Nepal, Bangladesh, and Taiwan. Equilibrium existing between Matrix metalloproteinases (MMP) & tissue inhibitors of matrix metalloproteinases is imperative for the normal integrity of connective tissues. However, this mechanism is disturbed in the presence of OSF, resulting in an increase in the extracellular matrix. Methods: It is an analytical study including two groups with a total of 60 participants. The first group consists of 30 healthy participants and the other group consists of 30 patients presenting with oral submucous fibrosis. Collected samples of saliva were stored at -80 °C after centrifugation. For ELISA investigation, the procedure was performed as per manufacturer’s instruction. Salivary matrix metalloproteinases- 12 concentration was estimated with the help of a standard curve. Data was analysed using SPSS 23. Mann Whitney test was applied to determine the difference existing in Matrix metalloproteinases- 12 levels between healthy and Oral submucous fibrosis participants. p-value <0.05 was contemplated as significant. Results: Statistical investigation indicated significant difference in Matrix metalloproteinases- 12 levels between Oral submucous fibrosis and healthy group (p<0.05). Saliva samples obtained from oral submucous fibrosis patients demonstrated raised concentrations of Matrix metalloproteinases- 12 as compared to healthy participants. Conclusion: Our study demonstrates significant upsurge in Matrix metalloproteinases- 12 expression in samples of saliva obtained from oral submucous fibrosis patients as compared to healthy individuals. Therefore, salivary Matrix metalloproteinases- 12 could serve as a useful diagnostic marker for OSF.
SEGMENTAL FRACTURE OF THE CLAVICLE – UNCONVENTIONAL FRACTURE PATTERN OF A CONVENTIONALLY FRACTURED BONE: A CASE REPORT WITH REVIEW OF LITERATURE
Authors: Mohapatra Ashutosh , Arora Yuvraj , Choudhury Priyam , Jangir Rajat
Published: April 2022

Though clavicle fractures are routinely seen in clinical practice, rarely do we encounter segmental fractures. This unusual pattern of fracture in clavicle has been seldom reported previously. We present a case of segmental fracture of the left clavicle fracture in a 64year old who was treated successfully. A detailed literature review has been presented too.
CASE OF PNEUMOMEDIASTINUM AND SURGICAL EMPHYSEMA IN A PATIENT WITH COVID-19 PNEUMONIA, ON CPAP
Authors: Idrees Muhammad , Abdulmumeen Abdulfatahi , Khan Munir
Published: April 2022

An unusual case of a 35-year-old woman with COVID-19 pneumonia who suddenly desaturated while on continuous positive airway pressure leading to pneumomediastinum and surgical emphysema thereby requiring ventilatory support in intensive therapy unit. It is unclear from history and clinical assessment; whether this complication was directly related to COVID-19 pneumonia and it worsened with the initiation of CPAP, OR it was a direct complication of CPAP.
DIAGNOSTIC VALUE OF SERUM UREA, CREATININE, SODIUM AND POTASSIUM FOR COMPLICATED APPENDICITIS - A ONE YEAR RETROSPECTIVE STUDY
Authors: Maqbool Mishal , Khaliq Fatima , Mehboob Amina , Anis Salwa , Hussain Maqbool , Amjad Muhammad
Published: April 2022

Background: Acute appendicitis is a common surgical emergency and if complicated, manifesting as abscess, perforation, suppurative or gangrenous appendicitis, carries significant morbidity and mortality. Its early preoperative diagnosis can improve outcome in patients and reduce incidence of negative appendectomies. It, however, mandates identification of new diagnostic parameters for it. This retrospective study evaluates diagnostic accuracy of serum urea, creatinine, sodium and potassium for complicated appendicitis. Methods: 60 patients with suspected appendicitis were grouped into complicated and uncomplicated appendicitis based on histological reports. Preoperative laboratory results for serum urea, creatinine, sodium and potassium levels were obtained from hospital records. Diagnostic strength of these markers was calculated as specificity, sensitivity and area under curve. ROC curve analysis was used for their diagnostic accuracy. Results: The levels of serum urea, creatinine and K were not significantly different in uncomplicated and complicated appendicitis. However, sodium was significantly higher in complicated appendicitis. ROC curve analysis showed AUC values for all the studied variables to be greater than 0.5. However, none of the markers had good capability to differentiate complicated appendicitis from uncomplicated appendicitis. Conclusion: Serum urea, creatinine, sodium and potassium levels have shown a tendency to be predictive of complicated appendicitis but a strong association could not have been established. Hence, further investigation is warranted
Nalaten in de digitale wereld
Authors: Diks J.Th.M. , Lavrijssen N.
Published: April 2022

Nalaten in de digitale wereld

De samenleving digitaliseert, en deze ontwikkeling is ook van invloed op het erfrecht. Deze bijdrage zoomt in op de mogelijkheden en uitdagingen van digitale technologie voor het erfrecht vanuit een praktisch perspectief. Daarbij wordt onder andere ingegaan op het teletestament, de begrippen ‘digitaal goed’ en ‘digitale erfenis’, bitcoins en andere digitale betaalmiddelen, en accounts en data van de erflater.
Uiterste wilsbeschikkingen ter voldoening aan een natuurlijke verbintenis
Authors: Brinkman R.E.
Published: April 2022

Uiterste wilsbeschikkingen ter voldoening aan een natuurlijke verbintenis

In deze bijdrage wordt getracht antwoord te geven op de vraag of makingen beschouwd kunnen worden als de nakoming van een natuurlijke verbintenis. Zo dat het geval is, heeft dat tot gevolg dat de inkorting respectievelijk vermindering van die makingen (bij de legitieme portie en andere wettelijke rechten respectievelijk bij een ontoereikende nalatenschap) pas na andere makingen in aanmerking komt. De conclusie luidt dat een dergelijke making als zodanig moeilijk is in te passen in het systeem van de wet, maar bij wijze van inperking van de testeervrijheid, als fictie of als toepassing van de redelijkheid en billijkheid, niettemin als mogelijkheid moet worden erkend.
Reconciliation through Fiqh al-Aqalliyat: A Sri Lankan Perspective
Authors: Abdullah M.M.A.
Published: April 2022

Reconciliation activities are essential in Sri Lanka, which has a racially and religiously pluralistic environment. The doctrine of Fiqh al-Aqalliyyat (Minority Jurisprudence) introduced by modern Islamic scholars to formulate the life of minority Muslims includes many guidelines for reconciliation among those living in a pluralistic environment. Hence, the study aimed at finding the necessary guidelines that would be put forward through this doctrine for racial and religious harmony especially in the Sri Lankan context. Based on the review of the literature, the findings reveal that the theory contained proper guidelines for reconciliation, such as playing dual role in the plural context namely members of the race or religion they belong to, and citizens of the country they live in, maintaining flexibility in particular circumstance although each group has its own traditions with respect to the public interest in the plural context, accepting other traditions and avoiding being radical in maintaining individuality. This study could be a reference for future studies on reconciliation and plural circumstances.
Identifying Grammatical Mistakes among Learners of Arabic as a Second Language (Undergraduates of the Department of Arabic language of South Eastern University of Sri Lanka as a Model)
Authors: Ahana M.R.F. , Aliyar A.B.M. , Zunoomy M.S.
Published: April 2022

Learning and teaching Arabic to non-native speakers is not easy since it is a foreign language and an unexperienced language. Hence, learners of Arabic as a second language at the university level make mistakes to identify grammatical errors in simple sentences and construct correct sentences in them while they have studied Arabic grammar in Arabic colleges in Sri Lanka for 5-7 years and in government schools as well. This research aims to identify grammatical and linguistic errors in simple sentences when writing among second language learners of Arabic. Therefore, the researchers rely in this study on the descriptive-analytical method. The following data are also used to collect information. As for the primary data, the researcher deals with the questionnaire and observation. In the questionnaire, the researcher randomly selects 159 male and female students from the Department of Arabic Language at the South Eastern University of Sri Lanka. As for secondary data, it depends on books, magazines, research, and website articles. The researcher uses the analysis method with the help of using MS Excel to analyze and verify the obtained information and evaluate its results. This research has obtained several results, including; that the students have all knowledge of the theories of simple sentences, so they like to write simple sentences and are not confused about the beginning of simple sentences. But as for the practical side, they know the writing of simple sentences in various patterns at a medium level. They also correct the error in simple sentences at a medium level.
The Impact of a Teacher Professional Education Program on English Language Use
Authors:   Widya Mandala Surabaya Catholic University, Lie Anita , Tamah Siti Mina ,   Widya Mandala Surabaya Catholic University, Gozali Imelda ,   Widya Mandala Surabaya Catholic University
Published: April 2022

In 2018 the Indonesian Ministry of Education established a teacher certification program via a blended learning platform in partnership with teacher colleges. The program engages teacher-participants in online learning, face-to-face workshops on a designated campus, classroom action research and teaching practices. This study aims at exploring the impact of the certification on the teachers’ use of English in their teaching. The researchers conducted a survey and a proficiency assessment of these English teachers. The ninety teachers of English in this study demonstrated various levels of English proficiency. Then the researchers selected these teachers based on their scores, interviewed them, and observed their teaching. This study found that teachers’ participation in the certification program brought about different levels of changes in their use of English. While the immediate impact of the certification program on the English teachers’ language use was not clearly evident, some teachers showed renewed commitment to use English after several months had passed. Results of this study have yielded implications that English teachers’ sufficient proficiency is not a given capital at the beginning of teacher service. Thus, a serious collaboration among English teacher colleges, the Ministry of Education, the school stakeholders, and the professional learning communities is required to drive teachers of English to engage in their professional development continuously.
Simulation of corrosion protection methods in reinforced concrete by artificial neural networks and fuzzy logic
Authors: Afshar Alireza , Shokrgozar Ali , Afshar Abdollah , Afshar Amirhossein
Published: April 2022

In this study, the effect of protection methods regarding the corrosion decrement of steel in concrete was simulated by artificial neural networks (ANNs) and fuzzy logic (FL) approaches. Hot dip galvanizing as a protective coating, Ferrogard 901 corrosion inhibitor, a pozzolanic component, such as fly ash (FA) and micro-silica (MS), and eventually rebar AISI-304 were employed in concrete. Reinforced concrete samples were held under impres­sed voltage of 30 V in 3.5 % NaCl electrolyte for 350 hours toward a stainless-steel auxiliary electrode. Corrosion currents have been modelled using feed forward back propa­gation ANNs and FL methods. The results demonstrate good consistency between cor­rosion data and simulated models. Furthermore, the correlation coefficient criterion clearly indicates using pozzolanic materials, with a combination of MS and FA, can be introduced as one of the best corrosion protection methods, with a 35 % contribution factor in reinforced concrete.
Effect of Remifentanil on Postoperative Vomiting After Strabismus Surgery in Preschool Children: A Prospective Randomized Controlled Trial
Authors: Lee Hyun-Seong , Lee Ki Hwa , Lee Byeongcheol , Oh Daeseok , Shin Sung Hyun , Park Yei Heum
Published: April 2022

Background: Strabismus surgery and the use of opioid are risk factors of postoperative vomiting. We evaluated whether there is a dose-dependent effect of remifentanil on the incidence of postoperative vomiting. Methods: Sixty pediatric patients who were scheduled for strabismus surgery were enrolled. Patients were randomly divided into three groups; Group H (high-dose remifentanil group), Group L (low-dose remifentanil group), and Group C (control group). After endotracheal intubation, patients in the Group H and L received an intravenous bolus dose of remifentanil of 1.0 μg/kg and 0.5 μg/kg over 2 min, respectively. Group H and L patients received a continuous infusion of remifentanil (0.1 μg/kg/min) during the surgery. The patients in Group C did not have any dose of remifentanil. Intravenous fentanyl (1 µg/kg) was administered to the patients for postoperative pain control. Results: The primary outcome was a difference of the incidence of postoperative vomiting within 24 hours after surgery. There was no significant difference in incidence of postoperative vomiting between three groups. The degree of emergence agitation and postoperative pain did not show any significant difference between three groups. Conclusions: The intraoperative administration of remifentanil did not show dose-dependent effect on postoperative vomiting in pediatric strabismus surgery.
In Vivo Anti-Toxoplasma Effects of Dracocephalum polychaetum Essential Oil
Authors: Pourmohammad Amir Hossein , Khamesipour Faham , Jafarian-Dehkordi Mohsen
Published: April 2022

Background: Toxoplasma gondii is a parasite that lives inside its host cells, with cats reported as its final host. T. gondii causes toxoplasmosis infection, showing severe symptoms in infected fetuses and individuals with defective immune systems. Drugs used to treat toxoplasmosis have numerous side effects on patients, including toxicity and drug resistance. Objectives: This study aimed to investigate the same in vivo anti-Toxoplasma activity of Dracocephalum polychaetum essential oil. Moreover, this study aimed to investigate the effect of different concentrations of D. polychaetum essential oil on the survival rate of mice infected with T. gondii. Methods: The T. gondii RH strain was used in the present study. Moreover, 60 BALB/c mice aged 4 - 6 weeks with an average weight of 20 - 25 g were used to evaluate the in vivo anti-Toxoplasma effect of D. polychaetum essential oil. The BALB/c mice were divided into six groups of 10 cases. One negative control group received Phosphate buffered saline (PBS); two treatment groups received pyrimethamine (25 mg/kg) and sulfadiazine (500 mg/kg), and three other groups received 50, 100, and 200 mg/kg of essential oil, respectively. The data were analyzed with the Kaplan-Meier nonparametric method and log-rank test in SPSS software (version 16) at a significance level of 0.05. Results: The survival rate of the acutely infected mice was evaluated by the intraperitoneal injection of the essential oil (50, 100, and 200 mg/kg-1 day-1) infected with tachyzoites. There was no general significant difference between the mean survival rate of the studied groups (P > 0.05). However, essential oil and negative and positive controls that showed the best anti-Toxoplasma activity were assayed in triplicate at each concentration. Conclusions: A concentration of 200 mg/kg of D. polychaetum essential oil had a greater significant anti-Toxoplasma effect than other groups.
Engaged employees as leaders in workplace innovation
Authors: Lukić-Nikolić Jelena , Brkljač Milan , Mirković Vladimir
Published: April 2022

Innovations are the key to the long-term survival, growth, and development of any organization. For that reason, all organizations strive to have as much as possible successful innovations that consequently bring many positive effects to the entire economy. This paper points out the importance and role of engaged employees who take a leading role in organizational innovations. Engaged employees give their best effort during the performance of work tasks, try to create new, better ways to perform certain activities through cooperation and exchange of knowledge with colleagues, and try to improve the functioning of the entire organization. With their enthusiasm, perseverance, persistence, and sincere desire to give their contribution to the business of the organization, engaged employees are the important source of creativity and innovation in the workplace. At the organizational level, a significant role in the innovation process has the proposals of engaged employees who truly love their job, the organization in which they work and have the desire to dedicate themselves to additional innovative activities that are not in their job descriptions.
Overview of individual models of companies performance reporting: Business performances reporting
Authors: Pavlović Danijela , Pavlović Miloš , Grdinić Vladimir
Published: April 2022

For years, financial statements have been key instruments of the financial reporting process and a way for companies to communicate, primarily with external, but also internal stakeholders. However, modern business conditions of the company have imposed the need not only for adjustments in the processes related to management and operations, but also in the process of financial reporting and it lead to the business reports. The aim of this paper is to point out the need for reporting on all business performance of the company and not only financial, as well as to point out possible solutions in the form of certain conceptual frameworks. The subject of this paper are various forms of reporting on business performance of the company. The object of research are companies and their performance.
A bite wound from a stray or feral cat: Case report
Authors: Katica Muhamed , Obradović Zarema , Abdalaziz Mohamed , Bajrić Amela , Lučkin Amina
Published: April 2022

Introduction/Objective Cat bites can seriously harm human health, especially if the bite comes from a stray or feral cat who is not under veterinary supervision. Cat bites are the second most common mammal bites, second only to dog bites, and responsible for ¾ of all bites that result in infection. We are presenting the case of a young woman whose hand had been bitten by a stray or feral cat. The objective of this case study is to stress the importance of timely medical treatment and wound management based on guidelines for treating bites inflicted by stray or feral cats, aiming to prevent possible complications. Case report A 32-year-old woman was admitted and examined in the University of Sarajevo Clinical Centre Emergency Department on the third day after being bitten by a stray or feral cat, by which time all signs of inflammation had already developed at the site of the injury-her right hand. Medical help was provided based on guidelines that included specific wound dressings recommended for animal bites, a prescription of antibiotics, analgesics and an anti-tetanus shot. The patient fully recovered with no complications. Conclusion The specific anatomy of the cat's canines enables them to penetrate deeply into the bitten tissue, which can cause an innoculation of a wide range of microorganisms from the cat's mouth into the patient's bloodstream. This can cause serious inflammatory processes, especially in immunocompromised patients. Adequate medical treatment of injuries resulting from cat bites is necessary as soon as possible, but no later than 48 hours after the incident.
Dietary habits and nutritional status of school children in urban and rural environments
Authors: Živanović Srđan , Branković Suada , Kulić Veselinka , Hadživuković Natalija , Pavlović Jelena , Joković Sandra , Magdelenić Gordana
Published: April 2022

Objective. Proper nutrition means satisfying organism's needs for daily intake of energy and adequate amount of nutritional and protective substances which are essential for maintenance of physiological functions of organism and health. The aim of this study was to determine eating habits and nutritional status of school children. Methods. The research was designed as a cross-section study. It was carried out in primary school "Sveti Sava'' in Foča and primary school "Sveti Sava'' in Gacko, branch in Avtovac. The study included 110 pupils aged from 10 to 14 years. As a measuring instrument, anthropometric measurements (height and weight) were used as well as a questionnaire. Results. The questionnaire included primary school pupils of different gender and age. Among the respondents, there were 66 (60%) boys and 44 (40%) girls. Most of the pupils (80,9%) had normal body weight, 48 (43,6%) boys and 41 (37,3%) girls. Among overweight pupils, there was statistically significant larger number of male pupils who were overweight in comparison with female pupils (=8,490; p=0,037). Also, there was statistically significant larger number of overweight pupils from urban environment in comparison with pupils from the rural one (ch2=8,614; p=0,035). Most of the pupils regularly have breakfast (50,9%). There is statistical significance in that larger number of children from urban environment consume fast food daily in comparison with children from rural environments (ch2=10,187; p=0,006). Conclusion. Eating habits of the elementary school children are not satisfying, being reflected in frequent skipping of breakfast, overconsumption of sandwiches, snacks and candies, while healthy foods, such as fish and vegetables are deficient in nutrition.
Teleworking with families of children with disabilities
Authors: Glamočak Sandra , Uzelac Jovana , Golubović Špela
Published: April 2022

The pandemic caused by the coronavirus has led to great changes in the lives of a large number of families. As such, she imposed new patterns of behavior, which required daily adaptations to the new situation. The impact of the pandemic and adherence to all prescribed epidemiological measures, in order to combat coronavirus infection, has undoubtedly had a major impact on the families of children with disabilities. Work with children has been suspended, and for that reason all forms of direct support to children with disabilities and their families have been disabled. Instead, new forms of support have been introduced in the virtual environment. Teleworking involves providing support to the families of children with disabilities through video conferencing technology. Given the availability and access to technology, access to telecommunication services is an attractive and flexible option for families, especially during challenging situations of this type.
The QTc interval and treatment outcome of inpatients with COVID-19
Authors: Jovanović Jovan , Janković Slobodan , Zdravković Nataša , Davidović Goran , Veselinović Mirjana , Čanović Petar , Zarić Milan , Sazdanović Maja , Sazdanović Predrag , Pantić Katarina , Čekerevac Ivan , Folić Marko , Zečević-Ružić Dejana , Baskić Dejan , Đorđević Nataša , Milovanović Dragan
Published: April 2022

Objective. After the beginning of the COVID-19 pandemic caused by the SARS-CoV -2 virus, enormous pressure fell on the entire health system. Since there is no adequate cure for this disease, "off-label" use of several drugs (azithromycin, chloroquine, hydroxychloroquine, etc.) was resorted to. The aim of this study was to analyse QTc interval dynamics and its relationship with other factors which could influence outcome in patients with COVID-19. Methods. Study has observational, case-control design with retrospective data collection from medical files of adult patients, with RT-PCR confirmed COVID-19. The cases (n=30) were subjects with fatal outcome and the controls (n=169) were the survivors. The QTc interval was calculated on admission, during and after initial drug treatments with presumed activity against SARS-CoV-2, mostly antimalarials. Primary independent and outcome variables were QTc interval prolongation and all-cause mortality, respectively. Results. Study population included 120 males (60.3%), the mean patients age was 57.3+-15.8 years (+-SD). The most common comorbid illnesses were hypertension (98 patients), pre-existing arrhythmias (32) and diabetes mellitus (29). The most frequently prescribed QTc prolonging drugs were azithromycin (69.8% of patients), chloroquine (50.3%) and hydroxychloroquine (42.7%). Total of 131 patients (65.8%) had QTc interval increase >60 ms from baseline, of whom 5 had QTc prolongation >500 ms (2.5%). De novo ventricular tachyarrhythmias were registered at 14 patients (7%) and 13 (92.8%) of them died. Pre-existing arrhythmias (odds ratio 9.30, 95% confidence interval 2.91-29.73, p<0.001) and furosemide (8.94, 3.27-24.41, p<0.001) were independently associated with mortality but QTc prolongation (>480 ms) did not (1.02, 0.22-4.67, p=0.974). Case fatality rate was 15.1%, as 30 patients died during hospitalization. Conclusion. Clinical importance of drug-induced QTc interval prolongation of hospitalized patients with COVID-19 should be considered primarily within the context of other risks, particularly older age, pre-existing cardiovascular disorders and major electrolyte disturbances.
Erratum: Differences in colorectal cancer surgery outcomes in Serbia: Hospitals in organized colorectal cancer screening and other hospitals (2021, vol. 18, no. 1, pp. 8-13)
Authors: Editorial Board
Published: April 2022

U PONS Med Č 2021 / PONS Med J 2021; 18(1):8-13 u originalnom naučnom radu Differences in colorectal cancer surgery outcomes in Serbia: hospitals in organized colorectal cancer screening and other hospitals vrši se ispravka koautora umesto Danijela Radojičić treba da stoji Danijela Radoičić.
Development and implementation of a register of employees in the healthcare system of the Republic of Serbia
Authors: Krstić Maja , Milić Nataša
Published: April 2022

One of the main problems of human resource planning and development in the healthcare system lies in the lack of a comprehensive information system for their monitoring. Improvement of the data collection system on healthcare providers, their organisational structure and employees is necessary to ensure supervision over the development of human resources, healthcare planning and financing, monitoring the provision of services by healthcare professionals and other goals in line with the legislation in force. The register of employees in the Serbian healthcare system has been designed as a Web service with forms for data entry and mechanisms to store that data in a database, to search and export it. HTML, CSS and JavaScript were used to develop the Register of Employees, to design data entry forms as webpages, while PHP was used to link the forms with a database. The register of employees comprises 100 variables divided into the following sections: institution, organisational unit, job position, employee, specialisation, subspecialisation and work engagement of the employee. The Register of Employees was implemented by creating end-user accounts (for HR associates, analysts) and by training end-users to work with the Register of Employees (data entry and updating, data search, report generation). To evaluate the work of the Register of Employees, we used methods of validating the entered data and descriptive statistical methods to present the first results of its use. The Register of Employees was implemented, as of 1 August 2021, in 339 public healthcare institutions and 78 privately-owned healthcare institutions and practices in the Republic of Serbia. Data validation showed that mechanisms of data entry, storage and retrieval were working correctly. The first results of the use of the Registry of Employees demonstrate the value of its use in everyday practice. Use of the Registry of Employees can contribute to more efficient human resource management in the healthcare system and to the improvement of healthcare in the Republic of Serbia.
Quality of healthcare in the Republic of Serbia: The concept we still strive for
Authors: Marković Roberta , Radulović Olivera , Ignjatović Aleksandra , Stojanović Miodrag , Višnjić Aleksandar
Published: April 2022

Like all other fields, quality - and recently, excellence - are goals that healthcare strives for. The World Health Organisation defines the concept of quality of care as the "the degree to which health services for individuals and populations increase the likelihood of desired health outcomes". Thus defined, healthcare quality means that the healthcare service provided should be effective and efficient, safe and patient-oriented, provided in a timely manner, just and integrated. Countries around the world have committed to achieving the goals of the "Health for All" strategy, thus accepting healthcare quality as both their obligation, and as their goal. The concept of healthcare quality in the Republic of Serbia was developed on the foundations of the previous system, characterised in a high level of socialized healthcare, available free of charge to all age and social groups, grounded in the principles that the World Health Organisation recognises as essential principles in its documents. Strong primary healthcare is the corner stone of this system. Years of war, accompanied by economic and political sanctions, have impacted all sectors in the Republic of Serbia, including the healthcare sector, which was quite shaken. In 2000, a new reform of the healthcare system was launched, and already in 2004 public health institutes began implementing activities aimed at improving the quality of healthcare and patient safety, as part of the program of the Ministry of Health entitled "Monitoring the quality of work in healthcare institutions in the Republic of Serbia" and in line with the "Instruction on monitoring the quality of work in healthcare institutions". Years of investments into healthcare capacities and human resources followed, together with the definition of a legislative framework for quality monitoring. The Ministry of Health and the Institute of Public Health of Serbia "Dr Milan Jovanović Batut", together with the network of public health institutes, have adopted a set of multisector, strategic and planning documents and coordinated program implementation at all levels of health care. Many activities were implemented, and according to the Euro Health Consumer Index (EHCI), from 2012 to 2018, the healthcare system in the Republic of Serbia has significantly improved its quality. In 2018, with regards to quality, Serbia was awarded the title of the climber of the year. COVID-19 pandemic put the Serbian healthcare system before new challenges, and requirements related to quality maintenance and improvement have become even more complex. In these circumstances, provision of high-quality healthcare on all levels remains a value we keep striving for, emphasizing the leverages of total healthcare quality management that will truly be oriented towards a satisfied patient.
Erysipelas in a cat-bite victim caused by 'Pasteurella multocida': Case report
Authors: Gvozdenović Eleonora , Malinić Jovan , Nikolić Nataša , Katanić Nataša , Jovanović Milica , Dulović Olga
Published: April 2022

Introduction: Erysipelas is a characteristic form of acute superficial streptococcal cellulitis, usually treated in outpatient service, primarily with penicillin, or erythromycin, in cases where the patient is allergic to penicillin. We are reporting the case of a patient who was preventively treated with erythromycin, after a cat bite, but during treatment developed erysipelas, which, after a swab sample from the wound was analyzed, proved to be caused by Pasteurella multocida, resistant to erythromycin. Case report: A 53-year-old woman came to the outpatient clinic with clinical signs of erysipelas cruris. Seven days before, she had been bitten by her own cat. The wound was surgically treated, and erythromycin, 500 mg qid, was prescribed as prophylaxis of wound infection. There were no signs of infection. On the 5th day following the bite, the patient was running a very high fever (39.2°C), but she was without other symptoms, thus the fever was considered to be a symptom of the flu. On the following day, prominent erythematous swelling appeared around the site of the wound, with localized lymphangitis and regional lymphadenitis, and discharge from the wound. The diagnosis of erysipelas was made. The peripheral blood test results were as follows: WBC = 13.9 x 109 /l; NE = 82%, CRP = 43 IU. A swab sample was collected from the wound and the patient was started on penicillin. On the 7th day of penicillin administration, there were no signs of inflammation, while the blood test results were as follows: WBC = 5.1 x 109 /l; NE = 52%; CRP = 24 IU. Pasteurella multocida, resistant to erythromycin but sensitive to penicillin was isolated from the swab sample. Conclusion: Erysipelas, although an easily recognized clinical entity, can be caused by other microorganisms, besides streptococcus. It is very important to consider this in order to make an accurate diagnosis and prescribe the appropriate therapy.
Bacterial infections in patients in allogenic stem cell transplantation programs
Authors: Stanković Stefan , Đunić Irena
Published: April 2022

Introduction: Bacterial infections are common in patients enrolled in allogenic hematopoietic stem cell transplantation. Infections are the most common cause of illness and mortality in transplanted patients. The most common pathogens are Staphylococcus and Enterobacteriaceae, causing 25% of bacterial infections, each, followed by Enterococcus andP. aeruginosa. Aim: The aim of the paper is calculating the frequency of bacterial infections in patients enrolled in allogenic hematopoietic stem cell transplantation, at the Clinic for Hematology of the University Clinical Center of Serbia, as well as analyzing the epidemiological situation, the frequency of different clinical presentations of bacterial infections, and their effect on overall survival. Materials and methods: This retrospective cohort study enrolled 58 patients. The presence of bacteria was determined with standard microbial cultivation from samples. The diagnosis criteria for localized bacterial infection are a positive culture and characteristic clinical presentation. Sepsis is clinically diagnosed by a combination of a positive hemoculture and the existence of systemic inflammatory response. Management of bacterial infection starts empirically and is continued in keeping with antibiogram results. Patient survival was analyzed with the Kaplan-Meier method and compared with the log-rank test. Results: Bacterial infections were registered in 15 (25.9%) patients. The most common pathogens were Gram-negative bacteria (65.2%). The most common clinical presentation was sepsis (59.0%). Bacterial infection lethality was 60%. The Kaplan-Meier curve showed the median value for estimated patient survival in patients without bacterial infection to be 106.0 months (95% CI 85.2 - 163.3), while, for patients with bacterial infection, it was 14.0 (95% CI 8.9 - 19.1). The log-rank test showed a significant difference in the length of survival between these two groups (p < 0.001). Pseudomonas spp. was sensitive to colistin and/or meropenem. Klebsiella pneumoniae was sensitive to colistin. Conclusion: Bacterial infections are common at our clinic and are caused by endogenous opportunistic bacteria. Therefore, emphasis should be placed on the implementation of preventive measures aimed at preventing hospital-acquired infections.
The effect of social media influencers’ credibility on consumer’s purchase intentions through attitude toward advertisement
Authors: Ata Serhat , Arslan Hakan Murat , Baydaş Abdulvahap , Pazvant Ece
Published: April 2022

People incorporate and use the internet in their lives in line with the development of technology. Facebook, Twitter, Instagram, which are especially defined as social media (SM) tools, are among the daily routines of people. Thus, a great transformation has occurred in the SM advertising industry. Social media influencers (SMI) emerged as a result of facilitating communication on SM. Unlike other studies mostly evaluated over celebrities and no detailed on how SMI affects consumers purchasing behavior through advertisement, this study shows how the SMI affects consumer purchasing behavior by considering the sample size and for the first time conducted with a survey to fill the gap in the field. This study was an attempt to explore the effects of the influencers used as product supplements in advertisements in SM tools on consumers' advertisements and purchasing intentions. Stimulatingly, this study explore how SMI’s credibility effects customer purchase intention through advertisements. In line with this, Structural Equation Modeling (SEM) was used to clarify the model and to test hypotheses. Results show that the trustworthiness, expertise, and attractiveness of the influencer have a positive effect on the attitude towards the advertisement, while the attitude towards the advertisement had no effect on the purchase intention. These results might be guideway for businesses to pay more attention to the SMI attracting the consumer's attention, having sufficient equipment about the subject and how gaining the trust of the consumer through SMI.
A DECADE OF PROGRESS IN GLOBAL NEUROSURGERY
Authors:   University of Edinburgh, Steinruecke Moritz
Published: April 2022

With an additional 23,300 neurosurgeons needed to address the over 5 million unmet essential neurosurgical cases presenting in low- and middle-income countries (LMICs) each year, a global approach to safe and effective neurosurgery is essential. Global neurosurgery, defined as “an area for study, research, practice, and advocacy that places priority on improving health outcomes and achieving health equity” for neurosurgical patients worldwide, has delivered tangible progress in this challenge over the past decade. The movement has facilitated the training and education of neurosurgeons, has developed cost-effective technological solutions, and has reformed healthcare systems in LMICs. For example, the Weill Cornell Neurosurgery-Tanzania Collaboration and the Duke Neurosurgery East Africa Project have excelled in specific areas of neurosurgical training and technological innovation by working closely with local healthcare organisations. Global neurosurgical outcomes monitoring, as conducted by a UK National Institute of Health Research collaboration on traumatic brain injury, will continue to provide further insight into the areas of care that require most attention and investment. While the past ten years have brought significant progress, the prioritisation of global health outcomes and equity in neurosurgical care is a particularly valuable advancement due to the benefits yet to be gained. The appreciation of safe and effective neurosurgery as a key element of universal health coverage is highly encouraging as a sign of progress towards more equitable surgical care for patients around the world.
OPPORTUNITIES AND CHALLENGES FOR CAR T-CELL THERAPY IN CANCER
Authors:   Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Soundararajan Soundarya
Published: April 2022

Chimeric antigen receptor (CAR) T-cell therapy is a novel therapeutic T-cell engineering option, where T-cells obtained from a patient’s blood are engineered ex vivo to express specific tumour antigen receptors. The highly selective nature of CAR T-cell therapy has led to a revolution in cancer treatment. The use of CAR T-cell therapy has been successful in treating haematological malignancies and there is also a growing interest in using CAR T-cell therapy to target solid tumours. However, there are notable challenges with CAR T-cell therapy, including non-sustained responses, antigen escape, and life-threatening adverse effects. Studies are underway to improve the safety of CAR T-cell therapy by limiting their expression, producing switchable CAR T-cells, and producing genetically engineered T-cells that are equipped with genes to reduce adverse effects.
Improving the technique of precision strikes in teaching students of professional training of educational organizations of the Ministry of Internal Affairs of Russia fighting techniques of wrestling.
Authors: Aseev Sergey Viktorovich , Ermolenko Dmitrii Aleksandrovich
Published: April 2022

The subject of the study is to increase the effectiveness of the technique of precision strikes of students of educational organizations of the Ministry of Internal Affairs of Russia with the use of weights in special sets of exercises.The object of the study is the organization of the educational process of students of the Faculty of vocational training of educational organizations of the Ministry of Internal Affairs of Russia in the discipline "Physical training". The author examines in detail such aspects as the use of special weights and the improvement of coordination abilities. Special attention is paid to the analysis of the traditional system of training students of the Ministry of Internal Affairs of Russia; the use of weights in the form of weights not of the maximum weight, while improving coordination abilities in teaching students the accuracy of punches and kicks. В  The main conclusions of the study are that the process of teaching percussion techniques in physical training classes with students of vocational training on the topic "Strikes and protection from blows" contributes to an increase in the accuracy of punches and kicks than classes on the traditional training system. The author's contribution to the research of the topic is: the definition and justification of the purpose and objectives of the study, the choice of the subject and object of research, the justification of the author's methodology.The novelty of the research lies in the development of special complexes consisting of shock technique exercises, which improve the high-speed qualities of shock technique, the accuracy of hitting the target and coordination abilities.
Countering manifestations of extremism in the implementation of administrative supervision and judicial control in the field of communications, information technology and mass communications
Authors: Vodianaia Mariia , Lyashuk Anna Valer'evna
Published: April 2022

The article is aimed at further improving the legal support of law enforcement activities of internal affairs bodies in the field of countering extremism. The subject of the study is the norms of administrative legislation regulating public relations in the field of administrative supervision of the police and judicial control in the field of countering administrative offenses of extremist orientation in the telecommunications network "Internet", as well as materials of judicial practice and law enforcement activities of police officers. The work uses a set of general scientific methods of cognition, such as dialectical, hermeneutical and systematic approach. Private scientific methods were used, such as formal legal and statistical research methods. В  The authors consider in detail the problem of optimizing counteraction to extremism in the process of administrative supervision of the police, as well as as a result of judicial control over the resolution of cases of administrative offenses of extremist orientation identified during the implementation of state supervision in the field of communications, information technology and mass communications. The characteristic mistakes of law enforcement are revealed, consisting in the excessive application of administrative coercion measures to persons brought to administrative responsibility for extremism. The authors come to the conclusion that it is necessary to change the approach in the perception of the concept of "extremism" in the telecommunications sphere as a phenomenon of "extreme" radical behavior. The ways of improving legislation and law enforcement activities in this area are proposed.
Database of Buryat Genealogies: Major Approaches and Implementation
Authors: Rinchinov Oleg Sergeevich , Rinchinova Oyuuna Sanzhimitupovna
Published: April 2022

The article develops a database of archival sources covering Buryat family trees. Genealogic data were traditionally very important for Buryat society as they were linked to such aspects as administrative arrangement, economic activity and marital relations. Special importance of family relations in social organization was seen in spiritual life as it actualized the cult of ancestors. In the context of ethnocultural revival observed in the recent decades, the social significance of information resources on Buryat genealogies is increasing. The funds of the Center for Oriental Manuscripts and Xylographs of the IMBT SB RAS store a large number of materials on this topic. They were the basis the discussed database was developed on. To form a meta-collection of archival materials on this topic the authors used corpus analysis methods processing the general index formed on the basis of electronic archival cases titles of the Center for Oriental Manuscripts and Xylographs. To organize the data the methodology of authority control is applied. The ontology scheme of a family tree includes descriptive categories "Family", "Place", "Person". This makes it possible to implement user-friendly methods of data aggregation and visualization - GIS, hierarchical trees, social graphs, etc. which are integrated into a web application. Digitalization of archival and rare book funds contributes to the identification and formation of thematic meta-collections similar to the corpus of archival sources on Buryat genealogies considered in this article. This opens up new opportunities for a comprehensive disclosure of historical and cultural heritage.
Modeling the Past: 30 Years Later
Authors: Nasevich Vyachaslau
Published: April 2022

The article compares the author's work on modeling historical processes, completed 30 years ago, with the publication of a similar model devoted to some hypotheses of the penetration of the “steppe heritage” into the gene pool of European farmers of the Bronze Age. The changes that have occurred in the computer modeling of historical processes, which significantly increase their research potential, are characterized. On the example of the models under consideration, it is discussed in what aspects they help to clarify and develop knowledge about the past. The features of spatially explicit models, which are a subset of imitation models (simulations), are demonstrated, including the possibility of taking into account the genetic parameters of the modeled populations and subsequent comparison with aDNA. The degree of novelty of the results obtained in the two compared models is estimated. It is noted which results of the latest research and additional considerations should be taken into account in order to further bring the behavior of the model closer to reality. It is suggested that the modeling results make it possible to associate the origin of the “steppe heritage” not so much with the population of the Yamnaya culture, but with the contact zone in the south of Ukraine, where interaction with the late Trypillian and other agricultural cultures took place. The necessity of supporting with models any assumptions about historical processes that does not follow directly from empirical material in order to confirm the fundamental reproducibility of the proposed scenario is substantiated.