bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of needle-based confocal laser endomicroscopy on the therapeutic management of single pancreatic cystic lesions
Authors: Palazzo Maxime , Sauvanet Alain , Gincul Rodica , Borbath Ivan , Vanbiervliet Goeffroy , Bourdariat Raphaël , Lemaistre Anne-Isabelle , Pujol Bertrand , Caillol Fabrice , Palazzo Laurent , Aubert Alain , Maire Frédérique , Buscail Louis , Giovannini Marc , Marque Sébastien , Napoléon Bertrand
Published: August 2019

Background and aim

The diagnosis and therapeutic management of large single pancreatic cystic lesions (PCLs) represent major issues for clinicians and essentially rely on endoscopic ultrasound fine-needle aspiration (EUS-FNA) findings. Needle-based confocal laser endomicroscopy (nCLE) has high diagnostic performance for PCLs. This study aimed to evaluate the impact of nCLE on the therapeutic management of patients with single PCLs.

Methods

Retrospective and comparative study. Five independent pancreatic disease experts from tertiary hospitals independently reviewed data from a prospective database of 206 patients with single PCL, larger than 2 cm and who underwent EUS-FNA and nCLE. Two evaluations were performed. The first one included the sequential review of clinical information, EUS report and FNA results. The second one included the same data + nCLE report. Participants had to propose a therapeutic management for each case.

Results

The addition of nCLE to EUS-FNA led to significant changes in therapeutic management for 28% of the patients (p < 0.001). nCLE significantly increased the interobserver agreement of 0.28 (p < 0.0001), from 0.36 (CI 95% 0.33–0.49) to 0.64 (CI 95% 0.61–0.67). nCLE improved the rates of full agreement among the five experts of 24% (p < 0.0001), from 30 to 54%. With nCLE, the surveillance rate of benign SCAs fell by 35%, from 40 (28/70) to 5% (4/76).

Conclusion

The addition of nCLE to EUS-FNA significantly improves reliability of PCL diagnosis and could impact the therapeutic management of patients with single PCLs. ClinicalTrials.gov number, NCT01563133.
Fostering integrated mental models of different professional knowledge domains: instructional approaches and model-based analyses
Authors: Lehmann Thomas , Pirnay-Dummer Pablo , Schmidt-Borcherding Florian
Published: August 2019

Recent research on expert teachers suggests that an integrated understanding across the core domains of teachers’ knowledge is crucial for their professional competence. However, in initial teacher education pre-service teachers seem to struggle with the integration of knowledge represented in multiple domain-specific sources into a coherent structure (e.g., textbooks that focus either on content knowledge, on content-specific pedagogical knowledge, or on general pedagogical knowledge). The purpose of this study was to investigate the effectiveness of writing tasks (unspecific vs. argumentative) and prompts (i.e., focus questions) on pre-service teachers’ construction of a mental model that interrelates information from multiple domain-specific documents. Data of ninety-two pre-service teachers, who participated in a laboratory experiment where they read three domain-specific textbook excerpts and wrote essays for global comprehension, were analyzed using automated structural and semantic measures. In line with prior research, results indicated that prompts supported pre-service teachers in integrating domain-specific knowledge from multiple documents in their mental models. However, the automated structural and semantic measures did not support previous findings on the efficacy of argument tasks for knowledge integration. The findings and limitations are discussed, and conclusions are drawn for future research and for integrative learning environments in pre-service teacher education.
Authenticity and rumination mediate the relationship between loneliness and well-being
Authors: Borawski Dominik
Published: August 2019

In recent years, plentiful data has emerged indicating the detrimental effects of loneliness on well-being. One of the challenges for researchers dealing with this issue is to find the mechanism underlying the relationship. The present study investigated 293 adults, aged 19-40, and examined whether authenticity and rumination functioned as mediators in the relationship between loneliness and well-being (and its three domains – pleasure, engagement, and meaning). The results of the study confirmed the loneliness-well-being link and, additionally, revealed potential mechanisms explaining this relationship, which were of different character in the cases of the particular domains of well-being. As it turned out, authenticity was the sole significant mediator in the relationship between loneliness and meaning, and rumination played the role of key mediator between loneliness and pleasure. Both these mediators had their share in the indirect effects of loneliness on engagement and overall well-being. The relations revealed between loneliness and authenticity are, in turn, congruent with recent conceptualizations of authenticity, which emphasize the interpersonal sources of this variable.
Energy-saving operation approaches for urban rail transit systems
Authors: Gao Ziyou , Yang Lixing
Published: August 2019

With the accelerated urbanization in China, passenger demand has dramatically increased in large cities, and traffic congestion has become serious in recent years. Developing public urban rail transit systems is an indispensable approach to overcome these problems. However, the high energy consumption of daily operations is an emerging issue due to increased rail transit networks and passenger demands. Thus, reducing the energy consumption and operational cost by using advanced optimization methodologies is an urgent task for operation managers. This work systematically introduces energy-saving approaches for urban rail transit systems in three aspects, namely, train speed profile optimization, utilization of regenerative energy, and integrated optimization of train timetable and speed profile. Future research directions in this field are also proposed to meet increasing passenger demands and network-based urban rail transit systems.
Correction to: A global carbon market?
Authors: Pollitt Michael G.
Published: August 2019

The article “A global carbon market?” written by Michael G. POLLITT, was originally published electronically on the publisher’s internet portal (currently SpringerLink) on 27 February 2019 without open access. The copyright of the article changed on 15 July 2019 to © The Author(s) 2019 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.
Levodopa is effective in the treatment of three Chinese Tyrosine hydroxylase (TH) deficiency children
Authors: Hou Mei , Yang Chengqing , Hu Jingfei , Guo Ya , Liu Peipei , Liu Yedan , Song Jie , Wei Wei , Chen Zongbo
Published: August 2019

Tyrosine hydroxylase (TH) deficiency is a rare autosomal recessive inborn error of dopamine transmission, which the deficient gene is at the chromosome 11, also called‘Segawa Syndrome’. TH converts tyrosine into L‐DOPA, which is the direct precursor of catecholamine biosynthesis. TH deficiency causes a neurological disease with primary extrapyramidal signs and a variable response to L‐DOPA. We report three patients in China who were diagnosed with Tyrosine hydroxylase (TH) deficiency by genetic testing and clinical manifestations. After L‐DOPA treatment, their condition had sustained improvement.
Why America Loses Wars
Authors: Stoker Donald
Published: August 2019

How can you achieve victory in war if you don't have a clear idea of your political objectives and a vision of what victory means? In this provocative challenge to US policy and strategy, Donald Stoker argues that America endures endless wars because its leaders no longer know how to think about war, particularly limited wars. He reveals how ideas on limited war and war in general evolved against the backdrop of American conflicts in Korea, Vietnam, and Iraq. These ideas, he shows, were flawed and have undermined America's ability to understand, wage, and win its wars, and to secure peace afterwards. America's leaders have too often taken the nation to war without understanding what they want or valuing victory, leading to the 'forever wars' of today. Why America Loses Wars dismantles seventy years of misguided thinking and lays the foundations for a new approach to the wars of tomorrow.
Fatigue and Safety in Paramedicine
Authors: Donnelly Elizabeth A. , Bradford Paul , Davis Matthew , Hedges Cathie , Socha Doug , Morassutti Peter
Published: August 2019

Objectives

Extant research has established an empirical relationship between fatigue and safety-related outcomes. It is not clear if these findings are relevant to Canadian paramedicine. The purpose of this study was to determine if fatigue and shiftwork variables were related to safety outcomes in Canadian paramedics.

Methods

A survey was conducted with ten paramedic services in Ontario with a 40.5% response rate (n = 717). Respondents reported levels of fatigue, safety outcomes (injury, safety compromising behaviours, and medical errors/adverse events), work patterns (types of shifts, hours worked weekly) and demographic characteristics. Univariate and logistic regression analyses were used to assess for significant differences.

Results

In this sample, 55% of paramedics reported being fatigued at work. Fatigued paramedics were over twice as likely to report injuries, three times as likely to report safety compromising behaviors, and 1.5 times more likely to report errors/adverse outcomes. When controlling for fatigue, shift length variables did not consistently influence safety outcomes.

Conclusion

These results create preliminary evidence of a relationship between fatigue and safety outcomes in Canadian paramedicine. While more research is needed, these findings point to the influence fatigue has on safety outcomes and provide an indication that fatigue mitigation efforts may be worthwhile.
Is English resumption different in appositive relative clauses?
Authors: Loss Sara S. , Wicklund Mark
Published: August 2019

Resumptive pronouns are produced in English in unguarded speech in restrictive relative clauses and appositive relative clauses. However, numerous studies have found that resumptive pronouns in restrictive relative clauses are not acceptable. To our knowledge, no studies have examined the acceptability of resumptive pronouns in appositive relative clauses, despite hints in the literature that they may be more acceptable in appositive than in restrictive relative clauses. This article fills that gap. We found that resumptive pronouns were rated as more natural in appositive relative clauses than in restrictive relative clauses. These findings may be due to which currently undergoing a reanalysis from a relative pronoun to a solely connective word, as has been suggested in the literature. A small-scale corpus search also reveals that appositive relative clauses with resumptive pronouns are increasing in American English.
CODIMENSION TWO CYCLES IN IWASAWA THEORY AND ELLIPTIC CURVES WITH SUPERSINGULAR REDUCTION
Authors: LEI ANTONIO , PALVANNAN BHARATHWAJ
Published: August 2019

A result of Bleher, Chinburg, Greenberg, Kakde, Pappas, Sharifi and Taylor has initiated the topic of higher codimension Iwasawa theory. As a generalization of the classical Iwasawa main conjecture, they prove a relationship between analytic objects (a pair of Katz’s$2$-variable$p$-adic$L$-functions) and algebraic objects (two ‘everywhere unramified’ Iwasawa modules) involving codimension two cycles in a$2$-variable Iwasawa algebra. We prove a result by considering the restriction to an imaginary quadratic field$K$(where an odd prime$p$splits) of an elliptic curve$E$, defined over $\mathbb{Q}$, with good supersingular reduction at$p$. On the analytic side, we consider eight pairs of$2$-variable$p$-adic$L$-functions in this setup (four of the$2$-variable$p$-adic$L$-functions have been constructed by Loeffler and a fifth$2$-variable$p$-adic$L$-function is due to Hida). On the algebraic side, we consider modifications of fine Selmer groups over the$\mathbb{Z}_{p}^{2}$-extension of$K$. We also provide numerical evidence, using algorithms of Pollack, towards a pseudonullity conjecture of Coates–Sujatha.
Cross-Sex Best Friendships and the Experience and Expression of Jealousy within Romantic Relationships
Authors: Gilchrist-Petty Eletra , Bennett Lance Kyle
Published: August 2019

This study investigated cross-sex best friendships in the experience and expression of jealousy within romantic relationships. Survey data (N = 346) revealed engaged-to-be-married individuals, compared to single, dating and married individuals, have the most negative attitudes regarding cross-sex best friendships. Results further indicated preventive jealousy experience is a predictor of rival-focused jealousy expression, and reactive jealousy experience is a predictor of both constructive and destructive jealousy expressions. Findings also suggest attitudes toward cross-sex best friendships can mediate the relationship between how jealousy is experienced and expressed in relation to reactive jealousy experience and destructive jealousy expression. Implications are discussed regarding how cross-sex best friendships can adversely affect romantic relationships.
The Antiquity of Pearling in the Americas: Pearl Modification Beginning at Least 8,500 Years Ago in Baja California Sur, México
Authors: Ainis Amira F. , Fujita Harumi , Vellanoweth René L.
Published: August 2019

AMS radiocarbon dating of two modified pearls from the Covacha Babisuri site, Espíritu Santo Island, Baja California Sur, México, corroborates associated midden dates suggesting that traditional indigenous use and modification of pearls as items of adornment began at least 8,500 years ago. To our knowledge, these are the oldest modified pearls found in dated archaeological contexts anywhere in the world. The presence of similarly modified pearls in later components at Covacha Babisuri suggests that this custom continued throughout the Middle Holocene, and ethnohistoric accounts indicate that similar modifications of pearls continued up until the Historic Era. These data show a long history of cultural continuity in the region in pearl harvesting, modification, and use as adornment.
Personality and Chinese adolescents’ career exploration: The mediation effects of self-efficacy and perceived parental support
Authors: Wang Jiaying , Fan Weiqiao , Cheung Fanny M. , Wang Qian , Li Mengting
Published: August 2019

The study compared the contributions of self- and social-oriented personality factors to Chinese adolescents’ career exploration with a longitudinal perspective. The mediation effects of career decision self-efficacy and perceived parental support were also investigated. A total of 488 high school students in Hong Kong took three waves of a questionnaire survey at Grade 10, Grade 11 and Grade 12 respectively. The results indicated that adolescents’ career exploration at Grade 12 could be predicted by both self- and social-oriented personalities at Grade 10. Specifically, both self- and social-oriented personality factors could contribute to adolescents’ environmental exploration, and the effect was mediated by perceived parental support at Grade 11, after controlling for the effect of career exploration at Grade 11; whereas self-oriented personality factor could contribute to self-exploration, and the effect was mediated by career self-efficacy at Grade 11. The implications for career counseling and education for Chinese adolescents are discussed.
The Rise and Fall of a Parallel-Walled Structure: Assessing the Site Sequence at Pachamta
Authors: Raczek Teresa P , Shirvalkar Prabodh , Prasad Esha , Pandey Lalit
Published: August 2019

In this article, we investigate the chronology of a large parallel-walled mudbrick structure at the site of Pachamta in Rajasthan, India. Pachamta is larger than the contemporaneous Harappan site of Kalibangan and part of a society collectively known as the Ahar Culture. Recent excavations at Pachamta provided an opportunity to elaborate on the available dates for this society and to investigate the chronology of an enigmatic parallel-walled structure. The chronology and function of such prominent structures remains murky, although scholars have suggested that these buildings served as public storage because they resemble the granary at Harappa. Through excavation, our team collected data for assessing the Pachamta parallel-walled structure including construction methods, process of abandonment, and associated dates. The thirteen14C assays from the site and an associated phase and sequence model performed in OxCal 4.3 demonstrate that the building was constructed, used, and abandoned in a relatively brief period. If parallel-walled structures are storage buildings, then expansion of the building may indicate prosperity or surplus, while abandonment may indicate an end to abundance or a shift in resource management. Carefully dating the structure allows us to investigate the timing of social processes including political and economic shifts within the settlement.
Dietary n-6 and n-3 PUFA alter the free oxylipin profile differently in male and female rat hearts
Authors: Ferdouse Afroza , Leng Shan , Winter Tanja , Aukema Harold M.
Published: August 2019

Oxylipins are bioactive lipid mediators synthesised from PUFA. The most well-known oxylipins are the eicosanoids derived from arachidonic acid (ARA), and many of them influence cardiac physiology in health and disease. Oxylipins are also formed from othern-3 andn-6 PUFA such asα-linolenic acid (ALA), EPA, DHA and linoleic acid (LA), but fundamental data on the heart oxylipin profile, and the effect of diet and sex on this profile, are lacking. Therefore, weanling female and male Sprague–Dawley rats were given American Institute of Nutrition (AIN)-93G-based diets modified in oil composition to provide higher levels of ALA, EPA, DHA, LA and LA + ALA, compared with control diets. After 6 weeks, free oxylipins in rat hearts were increased primarily by their precursor PUFA, except for EPA oxylipins, which were increased not only by dietary EPA but also by dietary ALA or DHA. Dietary DHA had a greater effect than ALA or EPA on reducing ARA oxylipins. An exception to the dietaryn-3 PUFA-lowering effects on ARA oxylipins was observed for several ARA-derived PG metabolites that were higher in rats given EPA diets. Higher dietary LA increased LA oxylipins, but it had no effect on ARA oxylipins. Overall, heart oxylipins were higher in female rats, but this depended on dietary treatment: the female oxylipin:male oxylipin ratio was higher in rats provided the ALA compared with the DHA diet, with other diet groups having ratios in between. In conclusion, individual PUFA and sex have unique and interactive effects on the rat heart free oxylipin profile.
Reassessing the age of Karpathos ophiolite (Dodecanese, Greece): consequences for Aegean correlations and Neotethys evolution
Authors: Cordey Fabrice , Quillévéré Frédéric
Published: August 2019

While the Neogene history of the Eastern Mediterranean region is now fairly well understood, our knowledge of older regional palaeogeographies is less accurate, especially the positions of blocks and nappes constituting the Aegean Islands prior to the Cenozoic. Our study focuses on the ophiolite exposed on the island of Karpathos (Dodecanese), which is located in the Aegean fore-arc at a pivotal position between the ‘western’ and ‘eastern’ ophiolites of the Mediterranean region and where conflicting Late Jurassic and Late Cretaceous ages have led to diverging tectonic and palaeogeographic interpretations. To test these ages, we targeted the radiolarian cherts that depositionally overlie the ophiolite and extracted diagnostic radiolarian assemblages of Aptian (∼125−113 Ma), early–middle Albian (∼113−105 Ma) and Turonian (∼93.9−89.8 Ma) ages. These results suggest that previous Late Cretaceous K–Ar isotopic ages (from 95.3 ± 4.2 Ma to 81.2 ± 1.6 Ma) may have been reset by Late Cretaceous metamorphism or affected by argon loss. Overall, the new Early Cretaceous ages show that the Karpathos ophiolite should not be correlated with the Pindos Nappes of Greece or the ophiolites of Cyprus or Syria but rather with the Lycian Nappes of Turkey and their root located in the Izmir–Ankara–Erzincan Suture Zone. Therefore, the Karpathos ophiolite represents a remnant of the Northern Neotethys, not the Pindos Ocean or the proto-Eastern Mediterranean Basin.
Busy Directors and Shareholder Satisfaction
Authors: Chen Kevin D. , Guay Wayne R.
Published: August 2019

Prior research has examined the firm-level performance implications of “busy” boards. Firm-level analysis, however, masks important heterogeneity in the time constraints and expertise of individual busy directors. We develop and validate shareholder voting as a proxy for shareholders’ satisfaction. Our director-specific tests provide compelling evidence that the potential costs of busy directors outweigh their benefits. At the same time, we uncover new sources of heterogeneity among busy directors. For example, the downsides are more pronounced for directors who sit on boards where fiscal year ends cluster in the same month. Our analysis highlights the role of shareholder voting in board composition research.
Using the research on intergroup conflict in nonhuman animals to help inform patterns of human intergroup conflict
Authors: Ridley Amanda R. , Mirville Melanie O.
Published: August 2019

There is a large body of research on conflict in nonhuman animal groups that measures the costs and benefits of intergroup conflict, and we suggest that much of this evidence is missing from De Dreu and Gross's interesting article. It is a shame this work has been missed, because it provides evidence for interesting ideas put forward in the article.
Emotions in attacker-defender conflicts
Authors: Cernadas Curotto Patricia , Halperin Eran , Sander David , Klimecki Olga
Published: August 2019

The distinction between attackers and defenders might help refine the understanding of the role of emotions in conflicts. Here, we briefly discuss differences between attackers and defenders in terms of appraisals, action tendencies, emotional preferences, and brain activities. Finally, we outline how attackers and defenders may differ in their response to emotion-based interventions that aim to promote conflict resolution.
Dónde está la ball? Examining the effect of code switching on bilingual children's word recognition
Authors: MORINI Giovanna , NEWMAN Rochelle S.
Published: August 2019

Hearing words in sentences facilitates word recognition in monolingual children. Many children grow up receiving input in multiple languages – including exposure to sentences that ‘mix’ the languages. We explored Spanish–English bilingual toddlers’ (n = 24) ability to identify familiar words in three conditions: (i)single word(ball!); (ii)same-language sentence(Where's theball?); or (iii)mixed-language sentence(Dónde está laball?). Children successfully identified words across conditions; however, the advantage linked to hearing words in sentences was present only in the same-language condition. This work hence suggests that language mixing plays an important role on bilingual children's ability to recognize spoken words.
Early life stress is associated with reduced avoidance of threatening facial expressions
Authors: Kirkham Elizabeth J. , Levita Liat
Published: August 2019

Early neglect or maltreatment has been associated with changes in children's processing of emotional facial expressions, including a hypersensitivity to the emotion of anger. This may facilitate the avoidance of danger in a maltreating environment. However, few studies have examined whether experiences of early life stress (ELS) are associated with atypical avoidance responses towards emotional facial expressions, or whether the effects of ELS can be observed in adult participants. The present study therefore examined the effects of ELS on adults’ approach-avoidance tendencies towards angry, happy, and neutral facial expressions. Surprisingly, higher levels of ELS were associated with reduced avoidance of angry facial expressions among individuals with no evidence of mental illness. In contrast, there was no evidence of a relationship between ELS and avoidance of angry facial expressions among individuals with experience of mental illness. These novel findings suggest that ELS-related changes in social cognition can be observed years after the ELS itself occurred.
ALTICA, COAPEXCO, AND THE ROLE OF MIDDLEMEN IN FORMATIVE OBSIDIAN EXCHANGE
Authors: Johnson Nadia E. , Hirth Kenneth G.
Published: August 2019

Altica's location in the Patlachique Range, 10 km away from the Otumba obsidian source, suggests its potential role in the distribution of Otumba obsidian. Altica may have been an important Formative middleman and processing site for obsidian exchange within the Basin of Mexico. To the south, Coapexco's position along a natural, restricted inlet to the Basin of Mexico may have enabled it to function as a node for pooling and distributing material into the Basin. This paper combines geochemical sourcing and technological data drawn from several Early and Middle Formative obsidian assemblages to reconstruct the movement of obsidian in this period to identify obsidian sources and consumption sites. In doing so, the paper assesses the role that intermediary sites like Altica and Coapexco could have played in the processing and distribution of obsidian into more distant consumption sites.
Disorders of Consciousness, Past, Present, and Future
Authors: FINS JOSEPH J.
Published: August 2019

This paper, presented as the 2019 Cambridge Quarterly Neuroethics NetworkCharcot Lecture, traces the nosology of disorders of consciousness in light of 2018 practice guidelines promulgated by the American Academy of Neurology, the American College of Rehabilitation Medicine and the National Institute on Disability, Independent Living and Rehabilitation Research. By exploring the ancient origins of Jennett and Plum’s persistent vegetative state and subsequent refinements in the classification of disorders of consciousness—epitomized by the minimally conscious state, cognitive motor dissociation, and the recently described chronic vegetative state—the author argues that there is a counter-narrative to the one linking these conditions to the right to die. Instead, there is a more nuanced schema distinguishing futility from utility, informed by technical advances now able to identify covert consciousness contemplated by Jennett and Plum. Their prescience foreshadows recent developments in the disorders of consciousness literature yielding a layered legacy with implications for society’s normative and legal obligations to these patients.
A comparison of the modelled impacts on CVD mortality if attainment of public health recommendations was achieved in metropolitan and rural Australia
Authors: Alston Laura , Jacobs Jane , Allender Steven , Nichols Melanie
Published: August 2019

Objective:

To (i) determine the proportion of deaths from CVD that could be avoided in both rural and metropolitan Australia if public health recommendations were met; (ii) assess the impact on the rural CVD mortality; and (iii) determine if policy priorities should be different by rurality for CVD prevention.

Design:

A macro-simulation modelling study of population data. Population, risk factor and CVD death data stratified by rurality were analysed using the Preventable Risk Integrated Model. The baseline scenario was the current risk factor levels (including physical activity, smoking, diet and alcohol). The counterfactual scenario was the population levels of these risk factors expected if public health recommendations were met.

Setting:

Metropolitan and rural Australia.

Participants:

Rural- and metropolitan-dwelling adults in Australia.

Results:

Both populations would experience similar relative declines in the proportion of deaths from CVD. A total of 14 892 deaths from CVD would be avoided annually; with similar declines in the proportions of deaths by rurality. Critically, the order of policy priorities for public health recommendation attainment would differ by rurality CVD prevention, with addressing fat intakes being a higher priority in rural areas.

Conclusions:

Achieving public health recommendations in Australia would result in large declines in CVD mortality. Despite declines in overall CVD mortality under this scenario, an inequality in CVD burden would persist for rural populations. The order of risk factor priorities would differ by rurality.
HAADF-STEM Image Resolution Enhancement Using High-Quality Image Reconstruction Techniques: Case of the Fe3O4(111) Surface
Authors: Bárcena-González G. , Guerrero-Lebrero M. P. , Guerrero E. , Yañez A. , Nuñez-Moraleda B. , Kepaptsoglou D. , Lazarov V. K. , Galindo P. L.
Published: August 2019

From simple averaging to more sophisticated registration and restoration strategies, such as super-resolution (SR), there exist different computational techniques that use a series of images of the same object to generate enhanced images where noise and other distortions have been reduced. In this work, we provide qualitative and quantitative measurements of this enhancement for high-angle annular dark-field scanning transmission electron microscopy imaging. These images are compared in two ways, qualitatively through visual inspection in real and reciprocal space, and quantitatively, through the calculation of objective measurements, such as signal-to-noise ratio and atom column roundness. Results show that these techniques improve the quality of the images. In this paper, we use an SR methodology that allows us to take advantage of the information present in the image frames and to reliably facilitate the analysis of more difficult regions of interest in experimental images, such as surfaces and interfaces. By acquiring a series of cross-sectional experimental images of magnetite (Fe3O4) thin films (111), we have generated interpolated images using averaging and SR, and reconstructed the atomic structure of the very top surface layer that consists of a full monolayer of Fe, with topmost Fe atoms in tetrahedrally coordinated sites.
A novel reconfigurable microstrip fractal UWB antenna with six variable rejection frequency bands
Authors: Nemati Nasrin , Bemani Mohammad
Published: August 2019

In this paper, a new reconfigurable microstrip fractal ultra-wideband antenna with a capability of variable rejection frequency bands is presented. The main patch of this antenna has two modified C-shaped gaps. Also, on these c-shaped gaps, 10 ideal MEMS switches are used to produce band-notch frequencies at six different frequencies of: 5.4 GHz (5.2–5.5), 5.8 GHz (5.7–5.9), 6.1 GHz (5.9–6.3), 7 GHz (6.9–7.2), 7.9 GHz (7.7–8.1), and 8.4 GHz (8.2–8.6). This antenna is fed by a 50 Ω microstrip line and works in a wide bandwidth of 2.9–11 GHz. The antenna is designed and fabricated on an inexpensive substrate of FR4. Dimensions of the antenna are 31.2 × 38.4 mm. Measurement and simulation results are in good agreement.
Integrated pigweed (Amaranthus spp.) management in glufosinate-resistant soybean with a cover crop, narrow row widths, row-crop cultivation, and herbicide program
Authors: Hay Marshall M. , Dille J. Anita , Peterson Dallas E.
Published: August 2019

Successful pigweed management requires an integrated strategy to delay the development of resistance to any single control tactic. Field trials were implemented during 2017 and 2018 in three counties in Kansas on dryland (limited rainfall, nonirrigated), glufosinate-resistant soybean. The objective was to assess pigweed control with combinations of a winter wheat cover crop (CC), three soybean row widths (76, 38, and 19 cm), row-crop cultivation 2.5 weeks after planting (WAP), and an herbicide program to develop integrated pigweed management recommendations. All combinations of the four components were assessed by 16 treatments. All treatments with the herbicide program resulted in excellent (>97%) pigweed control and were analyzed separately from the other components. Treatments containing row-crop cultivation reduced pigweed density and biomass 3 and 8 WAP in all locations compared with the 76-cm row width plus no CC treatment. CC impacts were mixed. In Riley County, Palmer amaranth density and biomass were reduced; in Reno County, no additional Palmer amaranth control was observed; in Franklin County, the CC had greater waterhemp density and biomass compared with the treatments containing no CC. Narrow row widths achieved the most consistent results of all cultural components when data were pooled across locations: Decreasing row widths from 76 to 38 cm resulted in a 23% reduction in pigweed biomass 8 WAP and decreasing row width from 38 to 19 cm achieved a 15% reduction. Row-crop cultivation should be incorporated where possible as a mechanical option to manage pigweed, and narrow row widths should be used to suppress late-season pigweed growth when feasible. Inconsistent pigweed control from CC was achieved and should be given special consideration before implementation. The integral use of these components with an herbicide program as a system should be recommended to achieve the best pigweed control and reduce the risk of developing herbicide resistance.
Factors influencing broadcast-herbicide control of huisache (Vachellia farnesiana)
Authors: Clayton Megan K. , Lyons Robert K.
Published: August 2019

Huisache is a major brush problem on native rangelands and pastures in South Texas. Although herbicide applications to foliage provide very high plant-kill levels, the same herbicides have not proven reliable when applied as broadcast ground or aerial foliar treatments. Aerial and ground broadcast herbicide foliar treatments were applied to 31 huisache sites. Soil temperature and soil moisture were measured at a depth of 30 cm at the time of herbicide application. Cumulative rainfall before herbicide application was recorded. Across all aerial treatments, plant mortality was 69% for plants shorter than 2 m versus 40% for plants taller than 2 m. Across all aerial- and ground-treated sites, plants shorter than 2 m had an average 89% mortality when cumulative 2-wk rainfall was at least 50 mm, versus 72% mortality with cumulative rainfall less than 50 mm. Average plant mortality was 84% when 4-wk cumulative rainfall was at least 76 mm, versus 71% with rainfall less than 76 mm; and 85% when, on a dry-to-wet scale of 0 to 10, soil moisture measured at least 8, versus 71% when soil moisture measured less than 8. In a separate aerial trial, plant-mortality effects of spray droplet size (417, 630, and 800 µm) and spray volume (37.4 L ha−1 and 93.5 L ha−1) were replicated and tested at a single study site in 2014. Plant mortality was lowest for the 93.5 L ha−1 and 800 µm treatment. Plant mortality rates for other treatments were similar, demonstrating a greater importance of droplet size than spray volume. Targeting huisache trees shorter than 2 m, when cumulative rainfall has reached at least 50 mm or at least 76 mm 2 or 4 wk before application, respectively, as well as maintaining spray droplet sizes no larger than 630 µm can increase herbicide efficacy with foliar broadcast applications.
Estimation of Capillary Pressure in Unconventional Reservoirs Using Thermodynamic Analysis of Pore Images
Authors: Anbari Alimohammad , Lowry Evan , Piri Mohammad
Published: August 2019

Unconventional reservoirs comprise a growing portion of producible reserves due to increasing knowledge of their nature as well as significant advances in production technology. The development of advanced pore‐scale modeling techniques presents potential for better estimation of reservoir flow characteristics including relative permeability, saturation distributions, and capillary pressure. Although pore‐scale network models take into account the pore throat connections and the appropriate fluid properties, highly simplified pore cross‐sectional shapes are still employed when estimating the threshold capillary pressure for fluid‐fluid displacements in each pore element. As a result, there is a growing need for more realistic threshold capillary pressure estimates generated using pore geometries that honor the real pore topology. To this end, a semianalytical model is presented that allows the prediction of threshold capillary pressure as well as the capillary pressure versus saturation relationship for piston‐like fluid displacements using images of unconventional reservoir rock samples. The model was validated on three different idealized pore geometries and compared against available analytical solutions, resulting in an error of less than 1% for all cases. The model was compared to experimental data using fluid occupancy maps obtained using an X‐ray nano‐CT scanner during an oil imbibition sequence into a miniature reservoir shale sample. The capillary pressure versus wetting phase saturation relationship was also determined for a 2‐D focused ion beam scanning electron microscopy image slice. The presented model shows promise for enabling more advanced pore‐scale modeling of shale rock.
Paleomagnetism and Paleosecular Variations From the Plio‐Pleistocene Golan Heights Volcanic Plateau, Israel
Authors: Behar Nicole , Shaar Ron , Tauxe Lisa , Asefaw Hanna , Ebert Yael , Heimann Ariel , Koppers Anthony A. P. , Ron Hagai
Published: August 2019

Statistical analysis of geomagnetic paleosecular variation (PSV) and time‐averaged field has been largely based on global compilations of paleomagnetic data from lava flows. These show different trends in the averaged inclination anomaly (ΔI) between the two hemispheres, with small positive (<2°) anomalies in midsouthern latitudes and large negative (> −5°) anomalies in midnorthern latitudes. To inspect the large ΔI between 20°N and 40°N we augment the global data with a new paleomagnetic data set from the Golan‐Heights (GH), a Plio‐Pleistocene volcanic plateau in northeast Israel, located at 32–33°N. The GH data set consists of 91 lava flows sites: 40 sites obtained in the 1990s and 51 obtained in this study. The chronology of the flows is constrained by 57 40Ar/39Ar ages: 39 from previous studies and 18 from this study, which together cover most of the GH plateau. We show that the 1990s data set might be affected by block rotations and does not fully sample PSV. The Plio‐Pleistocene pole (86.3°N, 120.8°E, N = 44, k = 25, α95 = 4.4°), calculated after applying selection criteria with Fisher precision parameter (k) ≥ 100 and number of specimens per site (n) ≥ 5 is consistent with a geocentric axial dipole field and shows smaller inclination anomaly (ΔI = −0.4°) than predicted by global compilations and PSV models. Reexamination of the inclination anomaly in the global compilation using different calculation methods and selection criteria suggests that inclination anomaly values are affected by (1) inclusion of poor quality data, (2) averaging data by latitude bins, and (3) the way the inclination anomaly is calculated.
Enhanced Energy Dissipation in the Equatorial Pycnocline by Wind‐Induced Internal Wave Activity
Authors: Natarov A. , Richards K. J.
Published: August 2019

Numerical experiments show that in a zonally symmetric model of a tropical ocean forced only by transient winds both inertia‐gravity wave activity and the energy dissipation rate have a pronounced maximum in the pycnocline close to the equator regardless of the latitudinal distribution of the energy input into the ocean's mixed layer. We consider a number of factors that determine the spatial distribution of mixing and find that equatorial enhancement is due to a combination of three factors: a stronger superinertial component of the wind forcing close to the equator, wave action convergence at turning latitudes for equatorially trapped waves, and nonlinear wave‐wave interactions between equatorially trapped waves. The most important factor is wave action convergence at turning latitudes.
Gut-associated IgA+ immune cells regulate obesity-related insulin resistance
Authors: Luck Helen , Khan Saad , Kim Justin H. , Copeland Julia K. , Revelo Xavier S. , Tsai Sue , Chakraborty Mainak , Cheng Kathleen , Tao Chan Yi , Nøhr Mark K. , Clemente-Casares Xavier , Perry Marie-Christine , Ghazarian Magar , Lei Helena , Lin Yi-Hsuan , Coburn Bryan , Okrainec Allan , Jackson Timothy , Poutanen Susan , Gaisano Herbert , Allard Johane P. , Guttman David S. , Conner Margaret E. , Winer Shawn , Winer Daniel A.
Published: August 2019

The intestinal immune system is emerging as an important contributor to obesity-related insulin resistance, but the role of intestinal B cells in this context is unclear. Here, we show that high fat diet (HFD) feeding alters intestinal IgA+immune cells and that IgA is a critical immune regulator of glucose homeostasis. Obese mice have fewer IgA+immune cells and less secretory IgA and IgA-promoting immune mediators. HFD-fed IgA-deficient mice have dysfunctional glucose metabolism, a phenotype that can be recapitulated by adoptive transfer of intestinal-associated pan-B cells. Mechanistically, IgA is a crucial link that controls intestinal and adipose tissue inflammation, intestinal permeability, microbial encroachment and the composition of the intestinal microbiome during HFD. Current glucose-lowering therapies, including metformin, affect intestinal-related IgA+B cell populations in mice, while bariatric surgery regimen alters the level of fecal secretory IgA in humans. These findings identify intestinal IgA+immune cells as mucosal mediators of whole-body glucose regulation in diet-induced metabolic disease.
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
Authors: Wang Heming , Lane Jacqueline M. , Jones Samuel E. , Dashti Hassan S. , Ollila Hanna M. , Wood Andrew R. , van Hees Vincent T. , Brumpton Ben , Winsvold Bendik S. , Kantojärvi Katri , Palviainen Teemu , Cade Brian E. , Sofer Tamar , Song Yanwei , Patel Krunal , Anderson Simon G. , Bechtold David A. , Bowden Jack , Emsley Richard , Kyle Simon D. , Little Max A. , Loudon Andrew S. , Scheer Frank A. J. L. , Purcell Shaun M. , Richmond Rebecca C. , Spiegelhalder Kai , Tyrrell Jessica , Zhu Xiaofeng , Hublin Christer , Kaprio Jaakko A. , Kristiansson Kati , Sulkava Sonja , Paunio Tiina , Hveem Kristian , Nielsen Jonas B. , Willer Cristen J. , Zwart John-Anker , Strand Linn B. , Frayling Timothy M. , Ray David , Lawlor Deborah A. , Rutter Martin K. , Weedon Michael N. , Redline Susan , Saxena Richa
Published: August 2019

Excessive daytime sleepiness (EDS) affects 10–20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from the UK Biobank, with enrichment for genes expressed in brain tissues and in neuronal transmission pathways. We confirm the aggregate effect of a genetic risk score of 42 SNPs on daytime sleepiness in independent Scandinavian cohorts and on other sleep disorders (restless legs syndrome, insomnia) and sleep traits (duration, chronotype, accelerometer-derived sleep efficiency and daytime naps or inactivity). However, individual daytime sleepiness signals vary in their associations with objective short vs long sleep, and with markers of sleep continuity. The 42 sleepiness variants primarily cluster into two predominant composite biological subtypes - sleep propensity and sleep fragmentation. Shared genetic links are also seen with obesity, coronary heart disease, psychiatric diseases, cognitive traits and reproductive ageing.
Chromatin loops associated with active genes and heterochromatin shape rice genome architecture for transcriptional regulation
Authors: Zhao Lun , Wang Shuangqi , Cao Zhilin , Ouyang Weizhi , Zhang Qing , Xie Liang , Zheng Ruiqin , Guo Minrong , Ma Meng , Hu Zhe , Sung Wing-Kin , Zhang Qifa , Li Guoliang , Li Xingwang
Published: August 2019

Insight into high-resolution three-dimensional genome organization and its effect on transcription remains largely elusive in plants. Here, using a long-read ChIA-PET approach, we map H3K4me3- and RNA polymerase II (RNAPII)-associated promoter–promoter interactions and H3K9me2-marked heterochromatin interactions at nucleotide/gene resolution in rice. The chromatin architecture is separated into different independent spatial interacting modules with distinct transcriptional potential and covers approximately 82% of the genome. Compared to inactive modules, active modules possess the majority of active loop genes with higher density and contribute to most of the transcriptional activity in rice. In addition, promoter–promoter interacting genes tend to be transcribed cooperatively. In contrast, the heterochromatin-mediated loops form relative stable structure domains in chromatin configuration. Furthermore, we examine the impact of genetic variation on chromatin interactions and transcription and identify a spatial correlation between the genetic regulation of eQTLs and e-traits. Thus, our results reveal hierarchical and modular 3D genome architecture for transcriptional regulation in rice.
A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier
Authors: Petrosyan Astgik , Cravedi Paolo , Villani Valentina , Angeletti Andrea , Manrique Joaquin , Renieri Alessandra , De Filippo Roger E. , Perin Laura , Da Sacco Stefano
Published: August 2019

In this work we model the glomerular filtration barrier, the structure responsible for filtering the blood and preventing the loss of proteins, using human podocytes and glomerular endothelial cells seeded into microfluidic chips. In long-term cultures, cells maintain their morphology, form capillary-like structures and express slit diaphragm proteins. This system recapitulates functions and structure of the glomerulus, including permselectivity. When exposed to sera from patients with anti-podocyte autoantibodies, the chips show albuminuria proportional to patients’ proteinuria, phenomenon not observed with sera from healthy controls or individuals with primary podocyte defects. We also show its applicability for renal disease modeling and drug testing. A total of 2000 independent chips were analyzed, supporting high reproducibility and validation of the system for high-throughput screening of therapeutic compounds. The study of the patho-physiology of the glomerulus and identification of therapeutic targets are also feasible using this chip.
Dynamic beam steering with all-dielectric electro-optic III–V multiple-quantum-well metasurfaces
Authors: Wu Pin Chieh , Pala Ragip A. , Kafaie Shirmanesh Ghazaleh , Cheng Wen-Hui , Sokhoyan Ruzan , Grajower Meir , Alam Muhammad Z. , Lee Duhyun , Atwater Harry A.
Published: August 2019

Tunable metasurfaces enable dynamical control of the key constitutive properties of light at a subwavelength scale. To date, electrically tunable metasurfaces at near-infrared wavelengths have been realized using free carrier modulation, and switching of thermo-optical, liquid crystal and phase change media. However, the highest performance and lowest loss discrete optoelectronic modulators exploit the electro-optic effect in multiple-quantum-well heterostructures. Here, we report an all-dielectric active metasurface based on electro-optically tunable III–V multiple-quantum-wells patterned into subwavelength elements that each supports a hybrid Mie-guided mode resonance. The quantum-confined Stark effect actively modulates this volumetric hybrid resonance, and we observe a relative reflectance modulation of 270% and a phase shift from 0° to ~70°. Additionally, we demonstrate beam steering by applying an electrical bias to each element to actively change the metasurface period, an approach that can also realize tunable metalenses, active polarizers, and flat spatial light modulators.