bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of active occupational stress management on psychosocial and physiological wellbeing: a pilot study
Authors: Jukic Tomislav , Ihan Alojz , Strojnik Vojko , Stubljar David , Starc Andrej
Published: December 2020

Background

The aim of the study was to address the working population with an occupational stress prevention program using mHealth solution and encourage them for healthy lifestyle choices.

Methods

Seventeen participants were randomized from the corporate setting. A 24alife app with a good compliance program was selected. Test battery has been designed to test the physical readiness, psychological evaluation and biological blood markers for stress. Participants were followed up after 30, 60 and 90 days, respectively, within the intervention period. Weight of participants was tracked three times per month. Univariate analysis compared the continuous variables by One-Way Repeated-Measures ANOVA test when the data were normally distributed, or Wilcoxon rank sum test for abnormal distribution of variables.

Results

Participants used the app with a compliance rate of 94.1%. The psychological evaluation revealed higher motivation for work, lower burnout scores and participants gave subjective responses of better general wellbeing. Some of the participants lost up to four kg of body mass. Physical readiness has also improved.

Conclusions

Results of mHealth projects on corporate could include primary health care institutions and health ministry to extend the existing system to patients’ pockets where they can monitor their disease and increase the ability of self-care.
Correction to: The 2020 blast in the Port of Beirut: can the Lebanese health system “build back better”?
Authors: Landry Michel D. , Alameddine Mohamad , Jesus Tiago S. , Sassine Saydeh , Koueik Elie , Raman Sudha R.
Published: December 2020

An amendment to this paper has been published and can be accessed via the original article.
Rural context, single institution prospective outcomes after enhanced recovery colorectal surgery protocol implementation
Authors: Smucker Levi , Victory Jennifer , Scribani Melissa , Oceguera Luis , Monzon Raul
Published: December 2020

Background

Rural hospitals face unique challenges to adopting Enhanced Recovery protocols after colorectal surgical procedures. There are few examples of successful implementation in the United States, and fewer yet of prospective, outcomes-based trials.

Methods

This study drew data from elective bowel resection prospectively collected, retrospectively analyzed cases 2 years prior (n = 214) and 3 years after (n = 224) implementing an ERAS protocol at a small, rural health network in upstate New York. Primary outcomes were cost, length-of-stay, readmission rate, and complications.

Results

The implementation required changes and buy-in at multiple levels of the institution. There was a statistically significant reduction in mean length of stay (6.9 versus 5.1 days) and per-patient savings to hospital ($3000) after implementation of ERAS protocol. There was no significant change in rate of 30-day readmissions or complications.

Conclusions

The authors conclude that for rural-specific barriers to implementation of Enhanced Recovery protocols there are specific organizational strategies that can ultimately yield sustainable endpoints.
Balancing revenue generation with capacity generation: case distribution, financial impact and hospital capacity changes from cancelling or resuming elective surgeries in the US during COVID-19
Authors: Tonna Joseph E. , Hanson Heidi A. , Cohan Jessica N. , McCrum Marta L. , Horns Joshua J. , Brooke Benjamin S. , Das Rupam , Kelly Brenna C. , Campbell Alexander John , Hotaling James
Published: December 2020

Background

To increase bed capacity and resources, hospitals have postponed elective surgeries, although the financial impact of this decision is unknown. We sought to report elective surgical case distribution, associated gross hospital revenue and regional hospital and intensive care unit (ICU) bed capacity as elective surgical cases are cancelled and then resumed under simulated trends of COVID-19 incidence.

Methods

A retrospective, cohort analysis was performed using insurance claims from 161 million enrollees from the MarketScan database from January 1, 2008 to December 31, 2017. COVID-19 cases were calculated using Institute for Health Metrics and Evaluation models. Centers for Disease Control (CDC) reports on the number of hospitalized and intensive care patients by age estimated the number of cases seen in the ICU, the reduction in elective surgeries and the financial impact of this from historic claims data, using a denominator of all inpatient revenue and outpatient surgeries.

Results

Assuming 5% infection prevalence, cancelling all elective procedures decreases ICU overcapacity from 160 to 130%, but these elective surgical cases contribute 78% (IQR 74, 80) (1.1 trillion (T) US dollars) to inpatient hospital plus outpatient surgical gross revenue per year. Musculoskeletal, circulatory and digestive category elective surgical cases compose 33% ($447B) of total revenue.

Conclusions

Procedures involving the musculoskeletal, cardiovascular and digestive system account for the largest loss of hospital gross revenue when elective surgery is postponed. As hospital bed capacity increases following the COVID-19 pandemic, restoring volume of these elective cases will help maintain revenue. In these estimates, adopting universal masking would help to avoid overcapacity in all states.
Crystal structure of the yeast heterodimeric ADAT2/3 deaminase
Authors: Liu Xiwen , Chen Ruoyu , Sun Yujie , Chen Ran , Zhou Jie , Tian Qingnan , Tao Xuan , Zhang Zhang , Luo Guan-zheng , Xie Wei
Published: December 2020

Background

The adenosine-to-inosine (A-to-I) editing in anticodons of tRNAs is critical for wobble base-pairing during translation. This modification is produced via deamination on A34 and catalyzed by the adenosine deaminase acting on tRNA (ADAT) enzyme. Eukaryotic ADATs are heterodimers composed of the catalytic subunit ADAT2 and the structural subunit ADAT3, but their molecular assemblies and catalytic mechanisms are largely unclear.

Results

Here, we report a 2.8-Å crystal structure of Saccharomyces cerevisiae ADAT2/3 (ScADAT2/3), revealing its heterodimeric assembly and substrate recognition mechanism. While each subunit clearly contains a domain resembling their prokaryotic homolog TadA, suggesting an evolutionary gene duplication event, they also display accessory domains for additional structural or functional purposes. The N-lobe of ScADAT3 exhibits a positively charged region with a potential role in the recognition and binding of tRNA, supported by our biochemical analysis. Interestingly, ScADAT3 employs its C-terminus to block tRNA’s entry into its pseudo-active site and thus inactivates itself for deamination despite the preservation of a zinc-binding site, a mechanism possibly shared only among yeasts.

Conclusions

Combining the structural with biochemical, bioinformatic, and in vivo functional studies, we propose a stepwise model for the pathway of deamination by ADAT2/3. Our work provides insight into the molecular mechanism of the A-to-I editing by the eukaryotic ADAT heterodimer, especially the role of ADAT3 in catalysis.
An optimized base editor with efficient C-to-T base editing in zebrafish
Authors: Zhao Yu , Shang Dantong , Ying Ruhong , Cheng Hanhua , Zhou Rongjia
Published: December 2020

Background

Zebrafish is a model organism widely used for the understanding of gene function, including the fundamental basis of human disease, enabled by the presence in its genome of a high number of orthologs to human genes. CRISPR/Cas9 and next-generation gene-editing techniques using cytidine deaminase fused with Cas9 nickase provide fast and efficient tools able to induce sequence-specific single base mutations in various organisms and have also been used to generate genetically modified zebrafish for modeling pathogenic mutations. However, the editing efficiency in zebrafish of currently available base editors is lower than other model organisms, frequently inducing indel formation, which limits the applicability of these tools and calls for the search of more accurate and efficient editors.

Results

Here, we generated a new base editor (zAncBE4max) with a length of 5560 bp following a strategy based on the optimization of codon preference in zebrafish. Our new editor effectively created C-to-T base substitution while maintaining a high product purity at multiple target sites. Moreover, zAncBE4max successfully generated the Twist2 p.E78K mutation in zebrafish, recapitulating pathological features of human ablepharon macrostomia syndrome (AMS).

Conclusions

Overall, the zAncBE4max system provides a promising tool to perform efficient base editing in zebrafish and enhances its capacity to precisely model human diseases.
SKP1 promotes YAP-mediated colorectal cancer stemness via suppressing RASSF1
Authors: Tian Cong , Lang Tingyuan , Qiu Jiangfeng , Han Kun , Zhou Lei , Min Daliu , Zhang Zhiqi , Qi Dachuan
Published: December 2020

Background

Cancer stem cells (CSCs) have been recognized as an important drug target, however, the underlying mechanisms have not been fully understood. SKP1 is a traditional drug target for cancer therapy, while, whether SKP1 promotes colorectal cancer (CRC) stem cells (CRC-SCs) and the underlying mechanisms have remained elusive.

Methods

Human CRC cell lines and primary human CRC cells were used in this study. Gene manipulation was performed by lentivirus system. The mRNA and protein levels of target genes were examined by qRT-PCR and western blot. The sphere-forming and in vitro migration capacities were determined by sphere formation and transwell assay. The self-renewal was determined by limiting dilution assay. The tumorigenicity and metastasis of cancer cells were examined by xenograft model. The promoter activity was examined by luciferase reporter assay. Nuclear run-on and Chromatin immunoprecipitation-PCR (ChIP-PCR) assay were employed to examine the transcription and protein-DNA interaction. Co-immunoprecipitation assay was used to test protein–protein interaction. The relationship between gene expression and survival was analyzed by Kaplan–meier analysis. The correlation between two genes was analyzed by Spearman analysis. Data are represented as mean ± SD and the significance was determined by Student’sttest.

Results

SKP1 was upregulated in CRC-SCs and predicted poor prognosis of colon cancer patients. Overexpression of SKP1 promoted the stemness of CRC cells reflected by increased sphere-forming, migration and self-renewal capacities as well as the expression of CSCs markers. In contrast, SKP1 depletion produced the opposite effects. SKP1 strengthened YAP activity and knockdown of YAP abolished the effect of SKP1 on the stemness of CRC cells. SKP1 suppressed RASSF1 at both mRNA and protein level. Overexpression of RASSF1 abolished the effect of SKP1 on YAP activity and CRC stemness.

Conclusion

Our results demonstrated that SKP1 suppresses RASSF1 at both mRNA and protein level, attenuates Hippo signaling, activates YAP, and thereby promoting the stemness of CRC cells.
Infant sex modifies associations between placental malaria and risk of malaria in infancy
Authors: Kakuru Abel , Roh Michelle E. , Kajubi Richard , Ochieng Teddy , Ategeka John , Ochokoru Harriet , Nakalembe Miriam , Clark Tamara D. , Ruel Theodore , Staedke Sarah G. , Chandramohan Daniel , Havlir Diane V. , Kamya Moses R. , Dorsey Grant , Jagannathan Prasanna
Published: December 2020

Background

Placental malaria (PM) has been associated with a higher risk of malaria during infancy. However, it is unclear whether this association is causal, and is modified by infant sex, and whether intermittent preventive treatment in pregnancy (IPTp) can reduce infant malaria by preventing PM.

Methods

Data from a birth cohort of 656 infants born to HIV-uninfected mothers randomised to IPTp with dihydroartemisinin–piperaquine (DP) or Sulfadoxine–pyrimethamine (SP) was analysed. PM was categorized as no PM, active PM (presence of parasites), mild-moderate past PM (> 0–20% high powered fields [HPFs] with pigment), or severe past PM (> 20% HPFs with pigment). The association between PM and incidence of malaria in infants stratified by infant sex was examined. Causal mediation analysis was used to test whether IPTp can impact infant malaria incidence via preventing PM.

Results

There were 1088 malaria episodes diagnosed among infants during 596.6 person years of follow-up. Compared to infants born to mothers with no PM, the incidence of malaria was higher among infants born to mothers with active PM (adjusted incidence rate ratio [aIRR] 1.30, 95% CI 1.00–1.71, p = 0.05) and those born to mothers with severe past PM (aIRR 1.28, 95% CI 0.89–1.83, p = 0.18), but the differences were not statistically significant. However, when stratifying by infant sex, compared to no PM, severe past PM was associated a higher malaria incidence in male (aIRR 2.17, 95% CI 1.45–3.25, p < 0.001), but not female infants (aIRR 0.74, 95% CI 0.46–1.20, p = 0.22). There were no significant associations between active PM or mild-moderate past PM and malaria incidence in male or female infants. Male infants born to mothers given IPTp with DP had significantly less malaria in infancy than males born to mothers given SP, and 89.7% of this effect was mediated through prevention of PM.

Conclusion

PM may have more severe consequences for male infants, and interventions which reduce PM could mitigate these sex-specific adverse outcomes. More research is needed to better understand this sex-bias between PM and infant malaria risk.

Trial registration ClinicalTrials.gov, NCT02793622. Registered 8 June 2016, https://clinicaltrials.gov/ct2/show/NCT02793622
Association of carbamylated high-density lipoprotein with coronary artery disease in type 2 diabetes mellitus: carbamylated high-density lipoprotein of patients promotes monocyte adhesion
Authors: Chen Zhongli , Ding Song , Wang Yan Ping , Chen Liang , Mao Jing Yan , Yang Ying , Sun Jia Teng , Yang Ke
Published: December 2020

Background

Increasing evidence showed that carbamylated lipoprotein accelerated atherosclerosis. However, whether such modification of high-density lipoprotein (HDL) particles alters in type 2 diabetes mellitus (T2DM) patients and facilitates vascular complications remains unclear. We aimed to investigate the alteration of the carbamylation in HDL among T2DM patients and clarify its potential role in atherogenesis.

Methods

A total of 148 consecutive T2DM patients undergoning angiography and 40 age- and gender-matched control subjects were included. HDL was isolated from plasma samples, and the concentration of HDL carbamyl-lysine (HDL-CBL) was measured. Furthermore, the HDL from subjects and in-vitro carbamylated HDL (C-HDL) was incubated with endothelial cells and monocyte to endothelial cell adhesion. Adhesion molecule expression and signaling pathway were detected.

Results

Compared with the control group, the HDL-CBL level was remarkably increased in T2DM patients (6.13 ± 1.94 vs 12.00 ± 4.06 (ng/mg),P < 0.001). Of note, HDL-CBL demonstrated a more significant increase in T2DM patients with coronary artery disease (CAD) (n = 102) than those without CAD (n = 46) (12.75 ± 3.82 vs. 10.35 ± 4.11(ng/mg),P = 0.001). Multivariate logistic regression analysis demonstrated that higher HDL-CBL level was independently associated with a higher prevalence of CAD in diabetic patients after adjusting for established cofounders (adjusted odds ratio 1.174, 95% confidence Interval 1.045–1.319, p = 0.017). HDL from diabetic patients with CAD enhanced greater monocyte adhesion than that from the non-CAD or the control group (P < 0.001). Such pro-atherogenic capacity of diabetic HDL positively correlated with HDL-CBL level. Furthermore, in-vitro incubation of carbamylated HDL (C-HDL) with endothelial promoted monocyte to endothelial cell adhesion, induced upregulation of cell adhesion molecules expression, and activated NF-κB/p65 signaling in endothelial cells. Inhibiting carbamylation of HDL or NF-κB activation attenuated the monocyte to endothelial cell adhesion and cell surface adhesion molecules expression.

Conclusions

Our study identified elevated carbamylation modification of HDL from T2DM patients, especially in those with concomitant CAD. We also evidenced that C-HDL enhanced monocyte to endothelial cell adhesion, indicating a potential pro-atherogenic role of C-HDL in atherosclerosis among T2DM patients.

Trial registrationhttps://register.clinicaltrials.gov, NCT04390711 Registered on 14 May 2020; Retrospectively registered
Intra-erythrocytes magnesium deficiency could reflect cognitive impairment status due to vascular disease: a pilot study
Authors: Sitzia Clementina , Sterlicchio Michele , Crapanzano Calogero , Dozio Elena , Vianello Elena , Corsi Romanelli Massimiliano Marco
Published: December 2020

Background and aims

Magnesium is a fundamental cation that regulates neuronal transmission, protein synthesis, energy metabolism. Magnesium deficiency mostly affects nervous and cardiovascular systems determining weakness, tremors, seizure and arrhythmias. This condition retains also a role in memory function and neuronal plasticity. Importantly magnesium deficiency could remain latent and asymptomatic resulting a risk factor for cardiovascular disease. In this sense we aim to determine magnesium status in patient presenting cognitive impairment of vascular origin.

Methods

21 healthy subjects and 27 patients presenting vascular cognitive impairment were included in this study. Both plasma and intraerythrocitary magnesium level were measured to detect magnesium deficiency and cognitive performance was evaluated trough Mini Mental State Evaluation (MMSE).

Results

Here we showed that patients presenting vascular cognitive impairment present intraerythrocitary magnesium level lower than age-matched healthy subjects. To note their plasma magnesium resulted within reference limit.

Conclusion

We suggest that intracellular magnesium laboratory measurement is needed to detect occult magnesium deficiency in population at risk. Magnesium supplementation could represent an adjuvant for healthy aging in high risk population.
An assessment of medical students’ proficiency regarding the hazards of radiological examinations on the health of workers and patients: a cross-sectional study from Palestine
Authors: Awadghanem Ahmed , Sbaih Mahmoud , Hasoon Mohammad , Yassin Zaher , Samara Ahmad M. , Maree Mosab , Zyoud Sa’ed H.
Published: December 2020

Background

The use of radiological examination is increasing worldwide. Since radiation exposure can result in many health hazards, medical professionals, as well as medical students, should possess adequate knowledge regarding radiation and its related hazards to protect themselves and the patients. Many studies have assessed medical students’ knowledge on this topic, but never in Palestine. In this study, we aimed to examine Palestinian medical students’ awareness and knowledge regarding radiological examination modalities and their risks on themselves and their patients.

Methods

This was an observational, cross-sectional, population-based study, conducted to assess the awareness of radiation exposure and its risks among Palestinian medical students. An online questionnaire was implemented on medical students at An-Najah National University. A total knowledge score that ranged from 0 to 22 was calculated for each participant, with higher scores indicating better knowledge regarding radiation doses and the related hazards.

Results

Two hundred eighty and seven students participated in our study, with a response rate of 71%. The average knowledge score of the participants was 10.97 ± 4.31 out of a maximum of 22 points. Male participants and participants in advanced study years achieved better knowledge scores (p-values were 0.034 and < 0.001, respectively). Perceived radiology knowledge was significantly associated with the actual knowledge score among the participants (p-value< 0.001). Receiving radiology lectures in fourth and fifth years significantly affected the participants’ knowledge score (p-values were < 0.001).

Conclusions

We found a severe lack of knowledge regarding radiation doses and related risks among medical students. Therefore, we recommend that medical schools update and supplement their curriculum regarding knowledge on radiation.
Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers
Authors: Zhang Le , Li Cuixia , Su Xiulan
Published: December 2020

An increasing number of studies have shown that long noncoding RNAs (lncRNAs) play important roles in diverse cellular processes, including proliferation, apoptosis, migration, invasion, chromatin remodeling, metabolism and immune escape. Clinically, the expression of MIR22HG is increased in many human tumors (colorectal cancer, gastric cancer, hepatocellular carcinoma, lung cancer, and thyroid carcinoma), while in others (esophageal adenocarcinoma and glioblastoma), it is significantly decreased. Moreover, MIR22HG has been reported to function as a competitive endogenous RNA (ceRNA), be involved in signaling pathways, interact with proteins and interplay with miRNAs as a host gene to participate in tumorigenesis and tumor progression. In this review, we describe the biological functions of MIR22HG, reveal its underlying mechanisms for cancer regulation, and highlight the potential role of MIR22HG as a novel cancer prognostic biomarker and therapeutic target that can increase the efficacy of immunotherapy and targeted therapy for cancer treatment.
Helmet continuous positive airway pressure versus high-flow nasal cannula in COVID-19: a pragmatic randomised clinical trial (COVID HELMET)
Authors: Tverring Jonas , Åkesson Anna , Nielsen Niklas
Published: December 2020

Background

Patients with COVID-19 and hypoxaemia despite conventional low-flow oxygen therapy are often treated with high-flow nasal cannula (HFNC) in line with international guidelines. Oxygen delivery by helmet continuous positive airway pressure (CPAP) is a feasible option that enables a higher positive end-expiratory pressure (PEEP) and may theoretically reduce the need for intubation compared to HFNC but direct comparative evidence is lacking.

Methods

We plan to perform an investigator-initiated, pragmatic, randomised trial at an intermediate-level COVID-19 cohort ward in Helsingborg Hospital, southern Sweden. We have estimated a required sample size of 120 patients randomised 1:1 to HFNC or Helmet CPAP to achieve 90% power to detect superiority at a 0.05 significance level regarding the primary outcome of ventilator free days (VFD) within 28 days using a Mann-Whitney U test. Patient recruitment is planned to being June 2020 and be completed in the first half of 2021.

Discussion

We hypothesise that the use of Helmet CPAP will reduce the need for invasive mechanical ventilation compared to the use of HFNC without having a negative effect on survival. This could have important implications during the current COVID-19 epidemic.

Trial registration

ClinicalTrials.gov NCT04395807. Registered on 20 May 2020
Pan-cancer identification of clinically relevant genomic subtypes using outcome-weighted integrative clustering
Authors: Arora Arshi , Olshen Adam B. , Seshan Venkatraman E. , Shen Ronglai
Published: December 2020

Background

Comprehensive molecular profiling has revealed somatic variations in cancer at genomic, epigenomic, transcriptomic, and proteomic levels. The accumulating data has shown clearly that molecular phenotypes of cancer are complex and influenced by a multitude of factors. Conventional unsupervised clustering applied to a large patient population is inevitably driven by the dominant variation from major factors such as cell-of-origin or histology. Translation of these data into clinical relevance requires more effective extraction of information directly associated with patient outcome.

Methods

Drawing from ideas in supervised text classification, we developed survClust, an outcome-weighted clustering algorithm for integrative molecular stratification focusing on patient survival. survClust was performed on 18 cancer types across multiple data modalities including somatic mutation, DNA copy number, DNA methylation, and mRNA, miRNA, and protein expression from the Cancer Genome Atlas study to identify novel prognostic subtypes.

Results

Our analysis identified the prognostic role of high tumor mutation burden with concurrently high CD8 T cell immune marker expression and the aggressive clinical behavior associated with CDKN2A deletion across cancer types. Visualization of somatic alterations, at a genome-wide scale (total mutation burden, mutational signature, fraction genome altered) and at the individual gene level, using circomap further revealed indolent versus aggressive subgroups in a pan-cancer setting.

Conclusions

Our analysis has revealed prognostic molecular subtypes not previously identified by unsupervised clustering. The algorithm and tools we developed have direct utility toward patient stratification based on tumor genomics to inform clinical decision-making. The survClust software tool is available at https://github.com/arorarshi/survClust.
Serum sCTLA-4 level is not associated with type 1 diabetes or the coexistence of autoantibodies in children and adolescent patients from the southern region of Saudi Arabia
Authors: Al-Hakami Ahmed
Published: December 2020

Background

The soluble form of CTLA-4 (sCTLA-4) is associated with several autoimmune diseases. The aim of the study is to measure the serum sCTLA-4 levels in type I diabetic (T1DM) patients and to assess the presence of autoantibodies for a possible association.

Methods

One hundred forty-two T1DM patients were enrolled in the study. Fifty of them were serologically positive for co-existing autoantibodies. One hundred and five subjects were enrolled in the study, as non-diabetic controls (1–17 years of age; median age—10 years). The serum samples of all the subjects were analyzed with ELISA to detect the concentration of sCTLA-4 and anti-GAD/IA2 IgG. Standard statistical analysis was conducted as required.

Results

Ninety-four (66%) subjects of T1DM patients and five (4.7%) subjects of the non-diabetic group had antibodies positive for anti-GAD/IA2. Serum sCTLA-4 was low in most of the subjects of both the diabetic and control groups (p = 0.18). In the control group, nine individuals (8.6%) were positive for sCTLA-4. Similarly, only seven patients (4.9%) in the T1DM group had high levels of sCTLA-4, of which two were found to be double positive for anti-thyroid peroxidase and anti-thyroglobulin antibodies. In addition, among the T1DM patients, no significant relationships were observed between sCTLA-4 levels and age of onset (p = 0.43), disease duration (p = 0.09), or glycemic control (p = 0.32).

Conclusion

Despite the previous findings of high sCTLA-4 levels in autoimmune diseases, serum levels of sCTLA-4 are not significantly different between T1DM patients and non-diabetic adolescents. Furthermore, we did not observe any association with autoantibody presence, glycemic control, or disease duration.
A controller deployment scheme in 5G-IoT network based on SDN
Authors: Cui Xin , Gao Xiaohui , Ma Yan , Wang Weihan
Published: December 2020

Due to the wide spread of 5G networks, network users have higher requirements for communication delays. Software-defined network is a new paradigm of decoupling the control logic from packet forwarding devices. We can reduce communication latency in the network by optimizing the location of the controller and improve the communication performance of the network. In this paper, the controller deployment problem of multi-network area is studied in order to reduce the average communication latency. In order to solve this problem, we proposed an optimized DPC algorithm. Specifically, on the basis of DPC algorithm we quoted the idea of triangular stability from the BeeDPC algorithm, and introduced SC measurement indicators, the degree of separation between sub-network regions and the degree of aggregation within the sub-network region, so as to divide the network region more reasonably. At the same time, we have break out of the constraints in the DPC algorithm and introduced closeness centrality to get a more reasonable placement scheme and reduced the limitations of the DPC algorithm. Simulation results have shown that the optimized DPC algorithm can effectively reduce the average delay between the control layer and the data layer, improve the network performance, and enhance network stability and reliability.
Irrigation suitability evaluation of Zamra irrigation scheme, Abergelle District of Wag-Himra Zone, Amhara Region Ethiopia
Authors: Sebnie Workat , Adgo Enyew , Kendie Hailu
Published: December 2020

Background

Assessment of suitable lands for irrigation is indispensable to plan and implement different programs in a cost-effective approach for sustainable land use planning and efficient utilization of the land. Hence selecting proper land use based on land suitability evaluation will enhance the productivity per unit area and ensures the sustainable use of land resources. Therefore, the research was designed to evaluate the suitability of the soil properties of Zamra irrigation scheme for irrigation purposes.

Method

For this study about 195.16 ha of land were evaluated for irrigation suitablity. Four soil profile pits were opened in the representative site of the scheme based on slope, texture, soil color and soil depth. Soil samples were collected from the soil mapping units for analysis of texture, electrical conductivity, and calcium carbonate content, whereas slope, drainage and soil depth were directly measured at the field. The evaluation was carried out using a parametric evaluation method.

Results

The results of the study revealed that four types of soils were identified namely, Rehodic Nitisol(eutric), Haplic Regosol (eutric) Eutric Regosol, Leptic Regosol (eutric, loamic), and Vertic Cambisol (Hypereutric). The soil texture consists of sandy loam and sandy clay loam at the surface and subsurface soil and the soil depth of study area varied from shallow to very deep. The soil of the scheme was free from salinity and the status of calcium carbonate was at a low level. The slope of the study area was ranged from flat (0–3%) to slopping (8–15%). Generally, 80.64 ha (41.32%) of the scheme was moderately suitable whereas 71.68 ha (36.73%) of the land was marginally suitable for irrigation. Due to major limiting factors of soil depth and slope about 42.84 ha of the land (21.95%) were not currently suitable for irrigation.

Conclusion

In the study area, the major limitations were slope and soil depth. Therefore, to increase production and productivity of the scheme, land improvement operations are suggested.
Phase-inherent linear visco-elasticity model for infinitesimal deformations in the multiphase-field context
Authors: Schwab Felix K. , Reiter Andreas , Herrmann Christoph , Schneider Daniel , Nestler Britta
Published: December 2020

A linear visco-elasticity ansatz for the multiphase-field method is introduced in the form of a Maxwell-Wiechert model. The implementation follows the idea of solving the mechanical jump conditions in the diffuse interface regions, hence the continuous traction condition and Hadamard’s compatibility condition, respectively. This makes strains and stresses available in their phase-inherent form (e.g. $$\varepsilon ^{\alpha }_{ij}$$

ε

ij

α

, $$\varepsilon ^{\beta }_{ij}$$

ε

ij

β

), which conveniently allows to model material behaviour for each phase separately on the basis of these quantities. In the case of the Maxwell-Wiechert model this means the introduction of phase-inherent viscous strains. After giving details about the implementation, the results of the model presented are compared to a conventional Voigt/Taylor approach for the linear visco-elasticity model and both are evaluated against analytical and sharp-interface solutions in different simulation setups.
Mycoplasma hyorhinis as a possible cause of fibrinopurulent meningitis in pigs? - a case series
Authors: Bünger Moritz , Brunthaler Rene , Unterweger Christine , Loncaric Igor , Dippel Maximiliane , Ruczizka Ursula , Schwarz Lukas , Griessler Alfred , Voglmayr Thomas , Verhovsek Doris , Ladinig Andrea , Spergser Joachim
Published: December 2020

Background

Mycoplasma hyorhinisis an invader of the upper respiratory tract in swine that is considered to have ubiquitous distribution. It is mainly known for causing polyserositis and polyarthritis in weaned piglets, even though the mechanisms of systemic spread are not fully understood.Mycoplasma hyorhinishas also been associated with other diseases in pigs such as pneumonia or otitis media, but so far has not been known to cause central nervous disorders. This case series reports the isolation ofMycoplasma hyorhinisfrom cerebrospinal fluid and/ or meningeal swabs from piglets originating from four different piglet producing farms in Austria.

Case presentation

On farm 1, coughing, stiff movement and central nervous signs occurred in nursery piglets.Mycoplasma hyorhiniswas the only pathogen isolated from meningeal swabs from two piglets showing central nervous signs. Fibrinopurulent leptomeningitis was only observed in one piglet. Only one of two nursery piglets from farm 2 showed mild central nervous signs but no histologic lesions;Mycoplasma hyorhiniswas isolated from cerebrospinal fluid of the piglet with neurologic signs.Mycoplasma hyorhiniswas isolated from cerebrospinal fluid of all three investigated piglets from farm 3, all of which showed central nervous signs and purulent leptomeningitis. Further,Streptococcus suiswas isolated from the cerebrospinal fluid of one piglet. Fibrinopurulent leptomeningitis was detected in two piglets from farm 4 that had died overnight without showing any clinical signs andMycoplasma hyorhiniswas isolated from meningeal swabs from both piglets.

Conclusion

While causality has yet to be proven by experimental infection and in situ detection of the pathogen in histologic sections, the findings of this study and the absence of other pathogens suggestMycoplasma hyorhinisas a potential causative agent of meningitis in swine.
Merging academy and healthcare in the Public Health training of medical students
Authors: Leão Teresa , Barros Henrique
Published: December 2020

Background

Public Health remains central to understand health and its determinants, and Public Health teams are essential for an integrated collaborative medical practice. However, current teaching of public health to medical students varies in the European Region though an investment in multidisciplinary workforce is recognised essential to deliver high quality public health services. A recent medical education curricula restructuring in the University of Porto Medical School resulted in the inclusion of a Public Health module linking academic teaching to field practice and provided the opportunity to make an initial appraisal of students’ perceptions.

Case study

We analysed final reports (n= 196), debriefing meetings notes (n= 2), and e-mails sent by students (n= 34) regarding the activities they observed or participated at, their contact with Public Health services’ teams, knowledge and critical appraisal, and opinion about the module. Students gained basic knowledge about how epidemiological surveillance, environmental health, health planning, and health promotion are performed in practice. They reported a better understanding of the roles and importance of Public Health services and its teams. Most considered that this module had an important role in their training. Some activities observed in the field lacked the needed standardisation to provide the students the feeling that core operations were experienced, which needs to be addressed in the future.

Conclusions

Public Health practice-based training within field institutions may bring a better understanding of the discipline and specialty for medical students. It may strengthen interconnectivity and coordination of healthcare agents, which may improve future medical practice with potential improvement of patient-centred care and in terms of public health response, and back their roles as health agents and decision-makers.
Improving low-voltage ride-through capability of a multimegawatt DFIG based wind turbine under grid faults
Authors: Nadour Mohamed , Essadki Ahmed , Nasser Tamou
Published: December 2020

Large integration of doubly-fed induction generator (DFIG) based wind turbines (WTs) into power networks can have significant consequences for power system operation and the quality of the energy supplied due to their excessive sensitivity towards grid disturbances. Under voltage dips, the resulting overcurrent and overvoltage in the rotor circuit and the DC link of a DFIG, could lead to the activation of the protection system and WT disconnection. This potentially results in sudden loss of several tens/hundreds of MWs of energy, and consequently intensifying the severity of the fault. This paper aims to combine the use of a crowbar protection circuit and a robust backstepping control strategy that takes into consideration of the dynamics of the magnetic flux, to improve DFIG’s Low-Voltage Ride Through capability and fulfill the latest grid code requirements. While the power electronic interfaces are protected, the WTs also provide large reactive power during the fault to assist system voltage recovery. Simulation results using Matlab/Simulink demonstrate the effectiveness of the proposed strategy in terms of dynamic response and robustness against parametric variations.
A methodological framework for futures studies: integrating normative backcasting approaches and descriptive case study design for strategic data-driven smart sustainable city planning
Authors: Bibri Simon Elias
Published: December 2020

Originally proposed as an alternative to traditional energy planning methodology in the 1970s, backcasting is increasingly applied in futures studies related to sustainability, as it is viewed as a natural step in operationalizing sustainable development. This futures study is concerned with data-driven smart sustainable urbanism as an instance of sustainable urban development—a strategic approach to achieving the long-term goals of urban sustainability. This is at the core of backcasting, which typically defines criteria for a desirable (sustainable) future and builds a set of feasible and logical pathways between the state of the future and the present. This paper reviews, discusses, and justifies the methodological framework applied in the futures study. This aims to analyze, investigate, and develop a novel model for data-driven smart sustainable cities of the future as a form of transformative change towards sustainability. This paper corroborates that the backcasting approach—as applied in the futures study—is well-suited for long-term urban problems and sustainability solutions due to its normative, goal-oriented, and problem-solving character. It also suggests that case study research is the most effective way to underpin and increase the feasibility of future visions. Indeed, the case study approach as a research strategy facilitates the investigation and understanding of the underlying principles in the real-world phenomena involved in the construction of the future vision in the backcasting study. The novelty of this work lies in the integration of a set of principles underlying several normative backcasting approaches with descriptive case study design to devise a framework for strategic urban planning whose core objective is clarifying which city model is desired and working towards that goal. Visionary images of a long-term future based on normative backcasting can spur innovative thinking about and accelerate the movement towards sustainability. The proposed framework serves to help researchers in analyzing, investigating, and developing future models of sustainable urbanism, smart urbanism, and smart sustainable urbanism, as well as to support policymakers and facilitate and guide their actions with respect to transformative changes towards sustainability based on empirical research.
Accounting and the US cannabis industry: federal financial regulations and the perspectives of Certified Public Accountants and cannabis businesses owners
Authors: Owens-Ott G. Suzanne
Published: December 2020

Background

Cannabis-related businesses (CRBs), in states where cannabis is legal, may be unable to obtain professional financial services including banking, insurance, and accounting because of federal laws and regulations. This qualitative study investigated the following research questions.

Why are some Certified Public Accountants unwilling to provide services to cannabis-related businesses?

How do CRBs compensate for lack of Certified Public Accountant services?

What does a certified public accountant need to know about the cannabis industry prior to engaging to provide services to CRBs?

Methods

Data for this grounded-theory qualitative study was gathered from twenty-three semi-structured phone and face-to-face interviews. Ten cannabis-related business owners were recruited from a convenience sample after attempting a broad recruiting effort. Thirteen Certified Public Accountants with active licenses in Colorado or Washington State participated from firms of varying size and willingness to serve the cannabis industry. The individual interviews, which lasted from twenty minutes to more than an hour, focused on the participants’ perceptions of the complexities of accounting and tax compliance for cannabis businesses.

Results

Eight of the thirteen Certified Public Accountants interviewed would not provide services to the cannabis industry with the primary reason given that cannabis is federally illegal. All ten of the cannabis business owners interviewed indicated they engage a Certified Public Accountant to provide tax services. Seven out of ten CRB participants and ten of the thirteen Certified Public Accountant participants indicated that extensive industry knowledge is needed for an accountant to competently provide services to a CRB.

Conclusions

CRB owners need to carefully consider the industry knowledge and experience of a potential Certified Public Accountant prior to engaging them. This study shows that US Certified Public Accountants should weigh the risk of federal prosecution and potential loss of the Certified Public Accountant license when deciding whether to serve a CRB client. The study also found that a Certified Public Accountant must commit to acquiring and maintaining substantial specialized knowledge related to tax Code Section 280E, internal controls for a cash-only or cash-intensive business, and the workings of the cannabis industry under the current regulatory conditions.
The accuracy of femoral component rotational measurements using computed tomography—a cadaveric study
Authors: Eseonu Onyedikachi , Cree Calum , Sambrook Martin , Blyth Mark , Jones Bryn
Published: December 2020

Background

CT scans can be used to assess the rotational alignment of the femoral component following total knee arthroplasty (TKA). This is done by calculating the posterior condylar angle (PCA).

However, the methods used may not account for the biomechanical functionality of the TKA components. This cadaveric study aimed to determine whether the axis of scanning (mechanical or anatomical) alters the results of PCA calculations.

Methods

CT scans of 12 cadaveric adult femora were performed along the anatomical axis and the mechanical axis. The PCA was determined on each CT scan by measuring the relationship of the prosthetic posterior condyles to the surgical epicondylar axis of the femur. The mechanical and anatomical axis groups were further subdivided into best-fit and multi-slice subgroups. As a control, the posterior condylar angle was also calculated on photographic images of each femur. Bland-Altman plots were used to determine the correlation between the PCA values obtained from the different scanning axes and measurement techniques.

Results

There was no significant difference between the PCA measurements derived from anatomical and mechanical axis CT scans. The Pearson correlation co-efficient also indicated good correlation between the two scanning axes.

Conclusion

The axis of scanning does not significantly affect the PCA measurements. Therefore, the measurements may be reliably used for clinical decision-making, regardless of the axis of CT scanning.
Obsessive-compulsive disorder presenting as chronic dysphagia—a case report
Authors: Sultan Sadia
Published: December 2020

Background

Medically unexplained oropharyngeal dysphagia (MUNOD) is a rare condition. It presents without demonstrable abnormalities in the anatomy of the upper aero-digestive tract or swallowing physiology. The aim of this case report is to discuss the unique presentation of OCD as chronic dysphagia.

Case presentation

A 65-year-old woman was admitted with dysphagia and weight loss in surgical department with history of undergoing repeated upper GI endoscopies and laryngoscopies. The patient was finally diagnosed to be suffering from chronic obsessive-compulsive disorder with poor insight and comorbid depression after 3 years of suffering and moving from hospital to hospital. The atypical presentation and poor insight were the major reasons for diagnostic difficulty in this particular case. The patient was given 60 mg fluoxetine and 2 mg risperidone which improved the patient’s symptoms by 40%.

Conclusion

This case explains the possibility of obsessive-compulsive disorder in patients presenting with unexplained somatic symptoms. It also demonstrated the importance of a timely psychiatric diagnosis and treatment and highlights the importance about awareness of psychiatric illness in doctor community which can reduce patient suffering and unnecessary invasive procedures.
State of Physician and Pharmacist Oncology Workforce in the United States in 2019
Authors: Shih Ya-Chen Tina , Kim Bumyang , Halpern Michael T.
Published: December 2020

PURPOSE:

To examine the geographic distribution of physician and pharmacist workforce specialized in oncology in the United States.

METHODS:

Using the National Provider Identifier data, we identified two types of oncology workforce via the healthcare provider taxonomy codes. Oncologists were physicians self-identified as providing oncologic care to patients. Oncology pharmacists were pharmacists with an oncology subspecialty. We calculated the geographic density of physician and pharmacist oncology workforce and used county-level cancer crude rates to quantify the demand for oncology workforce. We used spatial data to plot the density of oncology workforces relative to county-level cancer rates and compared the county-level density of oncologists and oncology pharmacists.

RESULTS:

Of the 30,553 members of the oncology workforce in 2019, 28,681 were oncologists and 1,090 were oncology pharmacists. The mean county-level density of oncologists was 2.94 (SD = 7.32) per 100,000 persons. Sixty-four percent of counties had no oncologists with primary practice location in that county and 12% had no oncologists in the local and adjacent counties. Counties in the top quartile of cancer rates had the highest percentage without any oncologists with primary practice location in the county (75%) and with no oncologists in the local as well as adjacent counties (16%).

CONCLUSION:

Geographically mismatched demand and supply characterized the current oncology workforce. Wide discrepancies in the supply of oncologists across geographic regions highlight the importance of developing core competencies for health professions not specialized in oncology to deliver quality cancer care in areas with unmet need for oncology care.