bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of a hydroxamamide-based bifunctional chelating agent to prepare technetium-99m-labeled bivalent ligand probes
Authors: Shimizu Yoichi , Ando Masato , Iikuni Shimpei , Watanabe Hiroyuki , Ono Masahiro
Published: September 2021

Hydroxamamide (Ham) is a thiol-free chelating agent that forms technetium-99m (99mTc)-complexes with a metal-to-ligand ratio of 1:2 under moderate reaction conditions. Therefore, Ham-based chelating agents will produce 99mTc-labeled compounds with a bivalent targeting scaffold. For their universal usage, we developed a novel Ham-based bifunctional chelating agent, “Ham-Mal”, with a maleimide group that can easily conjugate with a thiol group, for to preparing 99mTc-labeled bivalent ligand probes. Ham-Mal was synthesized by a four-step reaction, and then reacted with cysteine or c(RGDfC) to produce Ham-Cys or Ham-RGD. These precursors were reacted with 99mTcO4- for 10 min under room temperature to obtain 99mTc-(Ham-Cys)2 and 99mTc -(Ham-RGD)2. The cellular uptake level of 99mTc-(Ham-RGD)2 by U87MG (high Integrin ɑvβ3 expression) cells was significantly higher than that by PC3 (low Integrin ɑvβ3 expression) cells at 60 min after the incubation, and the uptake was significantly suppressed by pre-treatment for 15 min with excess c(RGDfK) peptide. In the in vivo study with U87MG/PC3 dual xenografted BALB/c-nu mice, the radioactivity of U87MG tumor tissue was significantly higher than that of PC3 tumor tissue at 360 min after the administration of 99mTc-(Ham-RGD)2. These results suggest Ham-Mal may have potential as a bifunctional chelating agent for 99mTc-labeled bivalent ligand probes.
Psychological factors shaping public responses to COVID-19 digital contact tracing technologies in Germany
Authors: Kozyreva Anastasia , Lorenz-Spreen Philipp , Lewandowsky Stephan , Garrett Paul M. , Herzog Stefan M. , Pachur Thorsten , Hertwig Ralph
Published: September 2021

The COVID-19 pandemic has seen one of the first large-scale uses of digital contact tracing to track a chain of infection and contain the spread of a virus. The new technology has posed challenges both for governments aiming at high and effective uptake and for citizens weighing its benefits (e.g., protecting others’ health) against the potential risks (e.g., loss of data privacy). Our cross-sectional survey with repeated measures across four samples in Germany ($$N = 4357$$N=4357) focused on psychological factors contributing to the public adoption of digital contact tracing. We found that public acceptance of privacy-encroaching measures (e.g., granting the government emergency access to people’s medical records or location tracking data) decreased over the course of the pandemic. Intentions to use contact tracing apps—hypothetical ones or the Corona-Warn-App launched in Germany in June 2020—were high. Users and non-users of the Corona-Warn-App differed in their assessment of its risks and benefits, in their knowledge of the underlying technology, and in their reasons to download or not to download the app. Trust in the app’s perceived security and belief in its effectiveness emerged as psychological factors playing a key role in its adoption. We incorporate our findings into a behavioral framework for digital contact tracing and provide policy recommendations.
Ag2CO3 containing magnetic nanocomposite as a powerful and recoverable catalyst for Knoevenagel condensation
Authors: Karimkhah Fatemeh , Elhamifar Dawood , Shaker Masoumeh
Published: September 2021

In this paper, the synthesis, characterization and catalytic application of a novel magnetic silica-supported Ag2CO3 (MS/Ag2CO3) with core–shell structure are developed. The MS/Ag2CO3 nanocomposite was prepared through chemical modification of magnetic MS nanoparticles with AgNO3 under alkaline conditions. The structure, chemical composition and magnetic properties of MS/Ag2CO3 were investigated by using VSM, PXRD, FT-IR, EDX and SEM techniques. The MS/Ag2CO3 nanocomposite was used as an effective catalyst for the Knoevenagel condensation under solvent-free conditions at 60 °C in an ultrasonic bath. The recovery and leaching tests were performed to study the nature of the MS/Ag2CO3 catalyst under applied conditions.
Aerobic oxidation of primary amines to amides catalyzed by an annulated mesoionic carbene (MIC) stabilized Ru complex
Authors: Yadav Suman , Reshi Noor U Din , Pal Saikat , Bera Jitendra K.
Published: September 2021

A Ru complex, stabilized by an annulated mesoionic carbene ligand, catalyzes the aerobic oxidation of a host of primary amines to amides in high yields and excellent selectivity. Kinetics, Hammett and DFT studies provide mechanistic insight.
Effect of surface wettability on the interfacial adhesion of a thermosetting elastomer on glass
Authors: Wang Ye , Hansen Christopher J. , Wu Chi-Chin , Robinette E. Jason , Peterson Amy M.
Published: September 2021

Interfacial adhesion is postively correlated with resin wettability.
Hierarchy and Reliability of the Preschool Language Scales–Fifth Edition: Mokken Scale Analysis
Authors: Hsiao Yu-Yu , Qi Cathy Huaqing , Hoy Robert , Dale Philip S. , Stump Glenda S. , Davison Megan Dunn , Xia Yinglin
Published: September 2021

Purpose

This study examined the psychometric properties of the Preschool Language Scales–Fifth Edition (PLS-5 English) among preschool children from low–socioeconomic status (SES) families.

Method

The PLS-5 was administered individually to 169 3- to 4-year-old children enrolled in Head Start programs. We carried out a Mokken scale analysis (MSA), which is a nonparametric item response theory analysis, to examine the hierarchy among items and the reliability of test scores of the PLS-5 Auditory Comprehension (AC) and Expressive Communication (EC) scales.

Results

The PLS-5 EC items retained a moderate Mokken scale with the inclusion of all the items. On the other hand, the PLS-5 AC items formed a moderate Mokken scale only with the exclusion of five unscalable items. The latent class reliability coefficients for the AC and the EC scale scores were both above .90. Several items that violated the invariant item ordering assumption were found for both scales.

Conclusions

MSA can be used to examine the relationship between the latent language ability and the probability of passing an item with ordinal responses. Results indicate that for preschool children from low-SES families, it is appropriate to use the PLS-5 EC scale scores for comparing individuals' expressive language abilities; however, researchers and speech-language pathologists should be cautious when using the PLS-5 AC scale scores to evaluate individuals' receptive language abilities. Other implications of the MSA results are further discussed.
A health condition assessment method of wind turbine generator system based on multiple turbines cooperation
Authors: Hu Yaogang , Shi Pingping , Fang Chao , Wang Yong , Liu Chuanliang , Ding Gang , Sun Meng
Published: September 2021

To improve the reliability and optimize the maintenance strategy of a large‐scale wind farm, a health condition assessment method of wind turbine generator system (WTGS) based on multiple turbines cooperation is presented in this paper. First, a health condition assessment framework is established by analyzing the existing monitoring characteristics of SCADA system. Second, to quantify the health condition of a WTGS, the concept of synthetic degradation factor is introduced and calculated using variable weight of assessment indices. Third, in order to acquire the health level of a WTGS effectively, based on the idea of multiple turbines cooperation, the health condition assessment model is proposed by utilizing the moving average method and quantile algorithm. Finally, by using SCADA monitoring data of a wind farm with 33 × 1.5 MW WTGSs including temperature, pressure, vibration, and so on; the processes of condition assessment are performed, and the effectiveness is also compared to a traditional assessment method with the fixed threshold. The results show that the condition assessment that utilizes the proposed method can acquire the change of health conditions and has a better coherence with real health conditions.
Influence of water scarcity on macronutrients contents in young leaves of wine grape cultivars
Authors: Candar Serkan , Açıkbaş Bekir , Ekiz Mümtaz , Zobar Damla , Korkutal İlknur , Bahar Elman
Published: September 2021

This study aimed to determine the variability of plant nutrition content in two-year old local and well-known wine grape cultivars under different water constraint scenarios. Own rooted and potted eight grapevine cultivars (cv. ‘Adakarası’, ‘Papazkarası’, ‘Karasakız’, ‘Karalahana’, ‘Yapıncak’, ‘Vasilaki’, ‘Cabernet Sauvignon’ and ‘Sauvignon Blanc’) were subjected to five irrigation treatments (100% daily irrigation of available water capacity (AWC), 75% irrigation of AWC, 50% irrigation of AWC, 25% irrigation of AWC, and no irrigation for 0% treatment) for two consecutive years during vegetative growth (May – late September). An increase in nitrogen, potassium and magnesium contents in leaf tissues with decreasing water amount was observed. Similar effect was found for phosphorus and calcium contents. The sulfur concentration in leaf tissues remained almost unchanged. In addition, the variability of genetic potential influenced the nutrient intake of the studied cultivars. The ability of grapevine cultivars to cope with the water deficit of the cultivars should definitely be assessed in adaptation strategies developed to make viticulture sustainable under the effects of the climate crisis.
Study on the development the market position company of fully electric vehicles
Authors: Susilo Wilhelmus Hary
Published: September 2021

Owing on decreased the marketing performances on automotive industries- energy generation, and storage industry in many firms. The research inquired of research gap within pursues the market- positions that it was conduct within resources of the corporate. Therefore, the research method conducted the one step approach within the confirmed strategy that conduct within an equation’s structural hybrid-model. The results- data was significantly contributed to the goal setting theory that it could drive to improve and enhanced within an innovation evidence in the digital-marketing and encompassed the marketing strategies that could pursued the market positions within the firms in the automotive fully electric vehicles industry as firms policies that innovation effort in digital marketing more focused than task marketing strategies and top managers.
Comparison of the Alkali-Silica Reactivity of North Cyprus and South Cyprus aggregates; preliminary studies using RILEM method
Authors: Akpinar Pinar , Zahedi Andisheh
Published: September 2021

Alkali-silica reaction (ASR) is regarded as one of the most deleterious concrete durability problems, known to cause severe deteriorations in reinforced concrete structures all around the world. ASR involves the reaction of alkaline concrete pore solution with silica minerals in the aggregates and as a result, hydrous alkali-silica gel is produced. Expansion caused by this gel upon absorbing moisture results in serious deterioration in concrete. Although the susceptibility of South Cyprus aggregates to ASR has been previously studied to a very limited extent in the past, no scientific information on the ASR susceptibility of North Cyprus aggregates are available in the related literature. Beşparmak (Pentadaktylos) Mountains (North Cyprus) and from Troodos Mountains (South Cyprus) are positioned close to each other; however, aggregates obtained from both mountains are known to differ in composition. This difference in composition has the potential to yield ASR performances varying significantly. The aim of this study was to carry out preliminary investigations on the alkali-silica reactivity performance of both North and South Cyprus aggregates under same conditions, in a systematic and comparative manner. Aggregates obtained from both mountains are tested in combination with CEM I and CEM II (with supplementary cemenetitious materials) under the exposure conditions of RILEM method AAR-2. Preliminary results showed that North Cyprus aggregates are potentially reactive when used with CEM II, where South Cyprus aggregates tested under same conditions are detected to have much higher levels of reactivity.
Analysis of the behaviour of Cable stayed bridge with different types of Pylon
Authors: Singh Priyanka , Baig Mirza Jahangir , Pandey Bhumika , Papreja Kartik
Published: September 2021

Cable stayed bridges are known for their good stability, It has been the most favorable use of structural design, for comparatively low designing and maintenance costs, and for effective structural characteristics. Therefore, this type of bridges are gaining popularity and are generally selected for long spans when compared to suspension bridges. A cable stayed bridge comprises of pylons with cables withstanding the weight of deck. There are different types of pylons i.e. ; H-type pylon, A-type pylon, inverted Y-type pylon, and diamond shaped pylon. In this paper the bridge design, model, and analyses for these different types of pylons is done using STAAD Pro. The comparison for three cases are done on the basis of shear force and bending moment in terms of self weight to obtain the most efficient type of pylon design. The results thus obtained are useful in limiting the drawbacks of other types of pylon.
The productivity of raw seeds and cuttings (leaf) of Salvia officinalis L. medicinal plants
Authors: Ulugova Safargul , Ruzmetov Umid , Hamzayev Abdushukur , Yunusov Askarboy
Published: September 2021

This article highlights the different portions of minerals in fertilizer mixture used for the acceleration of cultivation of the medicinal plant of Sage in soil – climatic conditions of Syrdarya region. The obtained results showed that different portions of minerals in fertilizer mixture have a positive effect on increasing the yield of seedlings and cuttings of the plant. When feeding with different sharings of mineral fertilizers used in an experiment, applying Nitrogen-90, Phosphorus - 60 and Potassium - 40 kg/ha norms has given good results to the rapid growth of plants. This article provides information on the technology of intensive cultivation of seedlings and cuttings of Salvia plant.
Study on the organic carbon and total nitrogen reserves in brown soils in the Chirchik river basin: A case study of Tashkent region, Uzbekistan
Authors: Bairov Abdunabi , Nuriddinova Khurshida , Juraev Shukhrat
Published: September 2021

To identify the role in carbon stabilization, the content and reserves of SOC and TN in brown soils of the middle mountains of the Chirchik river basin of the Tashkent region of Uzbekistan were investigated in connection with the climatic conditions of the slopes of various topographic aspects. The content and reserves of SOC and N were the highest in the soils of the northern slope, and the lowest in the soils of the southern slopes; the eastern slopes, in this respect, occupied an intermediate position. The climates of slope exposures were the main factors influencing on the content and reserves of SOC and N in the profile of brown soils, indicating the need for separate consideration of carbon emissions from soils which are developed on slopes of various topographic aspects.
Study on the process of droplet formation when liquid flows out of a capillary
Authors: Khodjiev Muksin , Alimov Orif
Published: September 2021

In this article, the law of interaction of air and fibrous materials emanating from two opposite pipelines is described in the theory of singular points by S.A. Chapligin, N.E. Zhukovsky function, theoretically studied using K. Schwarz’s integral formula, Lopital’s rule, complex potential field and canonical field.
Structure of the costume texture thickness investigation
Authors: Yusupova Nodira , Khamrayeva Sanovar , Jabbarov Jur’atbek , Jabbarova Nigora , Djabbarova Saida
Published: September 2021

The costume fabric is woven on the basis of tandoor sarja braids. Such textures are superficial in the body. When washing a suit sewn from the surface tissue of the body, in the process of using it only the body coverings are eroded and thinned, resulting in tissue rupture. This article presents the results of research on improving the quality, in particular, increasing the resistance to abrasion of cotton fabrics such as costume cloth. It is noted that the resistance of the fabric to abrasion depends on the indicators of its structure, that is, on the degree of mutual bending of the warp and weft threads or the supporting surface of the fabrics.
Strain characteristics of cotton yarns depending on the strain rate and methods of their manufacture
Authors: Baymuratov Bakhodir , Tulanov Shamsidin , Sultanov Karim , Ismailova Sabida
Published: September 2021

One of the main reasons for the nonlinearity of the tension diagrams of cotton yarns is the variability of their moduli of elasticity and plasticity under strain. The changes in strain moduli obtained from the tensile diagrams confirm this. The strain curve has ten parameters, the values of which depend on the method of yarn manufacture and the strain rate. Based on the results of processing the tension diagrams of cotton yarn, obtained by carded and combed systems by ring and rotor spinning (CD-carded ring-spun, OE-carded rotor-spun, CM-combed ring-spun), at strain rates from 0,0033 s-1 to 0,033 s-1, the values of these ten parameters were determined and analyzed. Their quantitative and qualitative dependence on the method of their manufacture and strain rate are shown.
Processing of teeth of saw blades of cotton processing machines with a stream of compressed air with abrasive particles
Authors: Shin Illarion , Shodmonqulov Zokhir , Nazarov Sakhrobjon , Iskandarova Nigora
Published: September 2021

In the article, it is presented materials on abrasive blasting of teeth of saw blades of cotton processing machines with particles of black silicon carbide. The micro-profile of the surface, characterized by the height and pitch of irregularities, after microcutting with abrasive particles is able to intensify the process of fiber separation by activating the tank surfaces of the teeth. This machining process is also accompanied by deformation hardening of the surface layer of the teeth, leading to an increase in the wear resistance and durability of the saws.
Intermittent disturbance combined N and P adding favor colony size and abundance of Microcystis flos-aquae
Authors: Yang Guijun , Zhong Chunni , Rui Zheng , Pan Wenwen , Liu Guofeng
Published: September 2021

Nutrients and disturbance are both important environmental factors in the freshwater ecosystem. Here we present data on the effects of intermittent disturbance (ID), nitrogen and phosphorus adding (+N+P), and intermittent disturbance combined N and P adding (ID+N+P) on colony size and abundance of Microcystis flos-aquae in lab experiments. Results showed that the mean colony sizes of M. flos-aquae in ID+N+P group were1.68, 1.56, 1.17 times that in the control, +N+P, ID groups, respectively. Moreover, the average number of M. flos-aquae in ID+N+P group were 1.47, 1.19, 1.42 times those in the control, +N+P, ID groups, respectively. The average concentration of EPS (extracellular polysaccharides) in ID and ID+N+P group was significantly higher than those in control and +N+P groups. Results demonstrated that intermittent disturbance combined N and P adding promoted colony size and abundance of M. flos-aquae. These results suggest that intermittent disturbance combined N and P adding plays an important role in the formation of Microcystis blooms in freshwater ecosystems.
BP neural network prediction for Si and S contents in hot metal of COREX process based on mathematical analysis and Deng’s correlation
Authors: Zhou Heng , Hu Yifan , Wen Bingjie , Wu Shengli , Kou Mingyin , Luo Yiwa
Published: September 2021

In COREX operation, the Si and S contents in hot metal are relatively high and easy-fluctuating, which is one of the problems affecting the practical operation. Accurate predictions of Si and S contents can provide theoretical references for stabilizing the fluctuations and decreasing the contents of Si and S in hot metal. Therefore, the present work established the prediction model of Si and S contents in hot metal in COREX based on BP neural network. The results show that the root-mean-square errors between the predicted value and actual value for Si and S are 0.098 and 0.0037, respectively. They are 0.070 and 0.0040 when the time-sequence lapse method is adopted, which turns out to be better. Therefore, the model is accurate and reliable to predict the Si and S contents in hot metal in COREX.
Moving Next-Generation Sequencing into the Clinic
Authors: Shetty Omshree , Gurav Mamta , Bapat Prachi , Karnik Nupur , Wagh Gauri , Pai Trupti , Epari Sridhar , Desai Sangeeta
Published: September 2021

With an advancement in the field of molecular diagnostics, there has been a profound evolution in the testing modalities, especially in the field of oncology. In the past decade, sequencing technology has evolved drastically with the advent of high-throughput next-generation sequencing (NGS). Subsequently, the single-gene tests have been replaced by multigene panel-based assays, deep sequencing, massively parallel whole genome, whole-exome sequencing, and so on. NGS has provided molecular diagnostics professionals a wonderful tool to explore and unearth the genetic alterations, underpinning the pathophysiology of the disease. However, this development has posed new challenges which consist of the following; understanding the technology, types of platforms available, various sequencing strategies, bioinformatics and data analysis algorithm, reporting of various variants, and validation of assays and overall for developing NGS assay for clinical utility. The challenges involved sometimes impede development of these high-end assays in laboratories. The present article provides a broad overview of our journey in setting up the NGS assay in a molecular pathology laboratory at a tertiary care oncology center. We hereby describe various important points and steps to be followed while working on the NGS setup, right from its inception to final drafting of the reports, with inclusion of various validation steps. We aim at providing a beginner’s guide to set up NGS assays in the laboratory using recommended best practices and various international guidelines.
Ramsay Hunt Syndrome: Viral Infection Coexisting with COVID-19
Authors: Mehta Madhuri , Jain Akanksha , Mehta Navroz
Published: September 2021

Severe acute respiratory syndrome coronavirus 2 presents with a multitude of different symptoms and signs, most described is respiratory compromise. Many viral and bacterial infections coexist with coronavirus disease 2019 (COVID-19). Many cranial neuropathies have also been reported, including facial nerve palsy and sudden sensorineural hearing loss individually. Ramsay Hunt Syndrome, which is conventionally described as acute peripheral facial neuropathy, associated with erythematous vesicular rash of pinna or external auditory canal can at times present with cochlear or vestibular symptoms along with it. We report the case of a 32-year-old male who presented with Ramsay Hunt syndrome with cochlear manifestation during his COVID-19 illness. Evaluation of the patient and further management have been described.
Adjuvant Radiotherapy in Grade II, Atypical Meningioma of the Skull Base
Authors: Bray David P. , Buster Bryan E. , Quillin Joseph W. , Press Robert H. , Eaton Bree R. , Olson Jeffrey J.
Published: September 2021

Introduction Atypical meningiomas (AM) are meningiomas that are more aggressive than their grade-I counterparts and have a higher rate of recurrence. The effect of adjuvant radiotherapy (ART) on AM of the skull base is not defined.

Methods A retrospective review of all AM's of the skull base primarily resected at our institution from 1996 to 2018 was completed. ART was defined as radiotherapy (RT) that occurred within 6 months of initial resection, regardless of Simpson's grade. Minimum time length of follow-up after resection was 2 years. Statistical analysis was performed using SAS.

Results There were a total of 59 skull base–located (SBL) AMs resected at our institution from 1996 to 2018. The average age of our cohort was 53.2 years. Gross total resection, defined as Simpson's grades I to III resection, was achieved in 36 (61%) of cases. Thirty-five of 59 (59%) patients received ART. Recurrence was observed in 14 patients (24%), and mean time to recurrence was 63.8 months. Patients who received ART had a lower observed rate of recurrence (8 vs. 46%); however, time to recurrence was not significantly different between the two populations.

Conclusion We observe that AM in the skull base location have higher recurrence rates than we would expect from grade-I meningioma. These data suggest that ART may offer benefit to the overall observed frequency of recurrence of SBL AM; however, the time to recurrence between patients who received ART and those who did not was not statistically significant in survival analysis.
A new morphological marker of the effects of acid rain in the tropics on the stem of
Authors: Andrade Guilherme Carvalho , Silva Luzimar Campos
Published: September 2021

Some of the largest remaining fragments of the Atlantic rainforest are affected by acid rain. Knowing the responses of its native plant species to acidity may be crucial to use them as bioindicators in affected areas. We tested the effects of pH 3.0 simulated acid rain on the stem of Libidibia ferrea (Mart. ex Tul.) L.P. Queiroz var. leiostachya (Benth.) L.P. Queiroz (ironwood, “pau-ferro”). Visual symptomatology consisted in dark spots on the stem that initiated on and irradiated from lenticels. As they grew larger, adjacent spots coalesced, conferring a blackened aspect to a large extension of the organ. Anatomically, the damage started with hypertrophy and increased accumulation of phenolic compounds in the outermost cell layers of the young, still subepidermal cork, which is what conferred the blackened aspect to the stem. In addition, epidermal cells showed turgor loss and ultimately collapsed, resulting in alteration of cell shape and a consequent alteration of epidermal relief. The stem of L. ferrea var. leiostachya was shown to be a more sensitive organ to the impacts of acid rain than the leaf. The dark spots visualised on the stem may be a promising macroscopic marker to be used in the biomonitoring of acid rain.
Reframing the human–wetlands relationship through a Universal Declaration of the Rights of Wetlands
Authors: Finlayson C. M. , Davies G. T. , Pritchard D. E. , Davidson N. C. , Fennessy M. S. , Simpson M. , Moomaw W. R.
Published: September 2021

The proposed Universal Declaration of the Rights of Wetlands is consistent with the principles of the rights of Nature, and reframes the human–wetlands paradigm away from one of degradation and loss to one of ecological sustainability that supports the Web of Life and continued delivery of Nature’s contributions to people. Given the significance of the role of wetlands in reversing climate destabilisation and biodiversity degradation and loss, the paradigm shift engendered by a Declaration opens new possibilities to align wetlands, climate, and biodiversity policy, consistent with the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services and Intergovernmental Panel on Climate Change (2021) proposals, to guide effective governmental and non-governmental mechanisms. Widening the acceptance of the concepts presented in the Declaration is part of a process to reframe human–wetlands relationships, and is ongoing and iterative.
Critique de Gravet & Lievois (2021): Vous avez dit littérature belge francophone ? Le défi de la traduction
Authors: Hayette Manon
Published: September 2021

Dès son indépendance en 1830, la Belgique a œuvré pour se créer une identité culturelle à travers l’élaboration
d’une littérature nationale. Cependant, la littérature belge francophone est souvent marginalisée et reste méconnue de son propre
public, si bien que la « belgitude » de ses auteurs – pour reprendre le terme de Klinkenberg – se voit effacée, au profit d’une
identité pseudofrançaise. En outre, cette littérature s’avère mal diffusée à l’international, car peu traduite. Il est donc
indispensable d’encourager la recherche en traductologie à ce sujet, ce qu’opère précisément le livre collectif commenté ici, qui
dérive du colloque « La traduction de la littérature francophone » organisé à l’Université de Mons en décembre 2018. Après une
introduction générale des éditrices Catherine Gravet et Katrien Lievois (p. 7–23), l’ouvrage se divise en quatre parties,
intitulées respectivement « Traduction et création », « Travail et Archives de traducteurs », « Traduction et réfraction » et
« Inventaires ».
Morality
Authors: Harris James A.
Published: September 2021

‘Morality’ considers Hume’s moral thought as developed in Book Three of A Treatise of Human Nature, various of his essays, and, especially, An Enquiry concerning the Principles of Morals. Hume engages with the moral sense theory of Francis Hutcheson in the Treatise. He then turned to essay writing, in relation especially to the essays of Joseph Addison in The Spectator. This turn to essay writing sees Hume modify the purely ‘anatomical’ philosophy of the Treatise in favour of a more practical engagement with the morality of common life. In his work, Hume considered the damage done to natural moral sentiments by religion, and by Christianity in particular. Hume displayed a lack of confidence in moral progress, and showed a sense of the persistence and pervasiveness of human unhappiness. Hume also made an important contribution to aesthetics.
Postscript
Authors: Harris James A.
Published: September 2021

‘Postscript' describes the final years of Hume’s life. Hume’s account of his life and achievements should not be taken wholly at face value. Hume’s career as a man of letters was a triumphant success, and by the time of his death he had situated himself at the centre of the European Enlightenment.
1. Beginnings
Authors: Thomas Gary
Published: September 2021

‘Beginnings’ traces the growth of schools and assesses the questions that have accompanied that growth. Detailed knowledge about the way schools first operated and the first evidence about the ways people thought about education come from ancient Greece, in the 5th to 4th centuries BCE. Roman schooling broadly followed the Greek model. Meanwhile, the invention of printing was, for the development of thought and education, world changing, leading ultimately to the flowering of interest in art, philosophy, literature, and science that was the Renaissance. The chapter then looks at how Czech teacher Comenius championed universal education. How did schools become instruments of capitalism, the current dominant economic system?
6. The curriculum
Authors: Thomas Gary
Published: September 2021

‘The curriculum’ argues that the generally accepted feeling is that the curriculum has been the jealously guarded province of teachers and education professionals, never to be penetrated by the common sense of politicians or public. This led to the establishment of the National Curriculum in the UK and a clutch of other European countries in the 1980s. Recent moves in the USA have aimed to introduce similar conformity, including the Common Core State Standards Initiative in 2010. This subject can't ignore the influence of ancient curricula and Jerome Bruner’s spiral model of the curriculum. What are the effects also of the hidden curriculum and the proliferation of tests on the curriculum?
Morphological and environmental differentiation as prezygotic reproductive barriers between parapatric and allopatric Campanula rotundifolia agg. cytotypes
Authors: Šemberová Kristýna , Svitok Marek , Marhold Karol , Suda Jan , Schmickl Roswitha E
Published: September 2021

Background and Aims

Reproductive isolation and local establishment are necessary for plant speciation. Polyploidy, the possession of more than two complete chromosome sets, creates a strong postzygotic reproductive barrier between diploid and tetraploid cytotypes. However, this barrier weakens between polyploids (e.g. tetraploids and hexaploids). Reproductive isolation may be enhanced by cytotype morphological and environmental differentiation. Moreover, morphological adaptations to local conditions contribute to plant establishment. However, the relative contributions of ploidy level and the environment to morphology have generally been neglected. Thus, the extent of morphological variation driven by ploidy level and the environment was modelled for diploid, tetraploid and hexaploid cytotypes of Campanula rotundifolia agg. Cytotype distribution was updated, and morphological and environmental differentiation was tested in the presence and absence of natural contact zones.

Methods

Cytotype distribution was assessed from 231 localities in Central Europe, including 48 localities with known chromosome counts, using flow cytometry. Differentiation in environmental niche and morphology was tested for cytotype pairs using discriminant analyses. A structural equation model was used to explore the synergies between cytotype, environment and morphology.

Key Results

Tremendous discrepancies were revealed between the reported and detected cytotype distribution. Neither mixed-ploidy populations nor interploidy hybrids were detected in the contact zones. Diploids had the broadest environmental niche, while hexaploids had the smallest and specialized niche. Hexaploids and spatially isolated cytotype pairs differed morphologically, including allopatric tetraploids. While leaf and shoot morphology were influenced by environmental conditions and polyploidy, flower morphology depended exclusively on the cytotype.

Conclusions

Reproductive isolation mechanisms vary between cytotypes. While diploids and polyploids are isolated postzygotically, the environmental niche shift is essential between higher polyploids. The impact of polyploidy and the environment on plant morphology implies the adaptive potential of polyploids, while the exclusive relationship between flower morphology and cytotype highlights the role of polyploidy in reproductive isolation.
Changes in floral shape: insights into the evolution of wildNicotiana(Solanaceae)
Authors: Teixeira Marcelo C , Quintana Isadora V , Segatto Ana Lúcia A , Maestri Renan , Freitas Loreta B , Augsten Mariana , Stehmann João R , Turchetto Caroline
Published: September 2021

Floral shape and size play a role in plant diversification and reproductive isolation. Different floral forms can rise by selective pressures by pollinators/ecological constraints and/or genetic drift. Nicotiana (Solanaceae) has c. 82 currently recognized species grouped in 13 sections. Nicotiana forgetiana and N. alata belong to section Alatae and present different floral traits related to their primary pollinators. These species co-occur in a region of plant endemism in southern Brazil marked by a mosaic between open grasslands and Araucaria forest. Here, we conducted a population-level sampling across the range of N. forgetiana and combined geometric morphometric analyses and ecological niche modelling to shed light on the patterns underlying intraspecific floral shape variation. Corolla shape and size varied significantly across the geographical distribution of N. forgetiana and ‘rastroensis’, a putative new species. These floral shape differences were related to variations in temperature, precipitation and elevation. We also observed a range of intermediate floral traits in two populations, and our results of geometric morphometric analyses reveal morphological overlap between N. alata and N. forgetiana. Moreover, we found that habitat suitability for both species was impacted by past climatic oscillations, with severe reduction for N. forgetiana during the Last Glacial Maximum. We discuss the results to shed light on the evolution of N. forgetiana.
Political Life of Treaties: Indeterminacy, Interpretation and Political Consequences
Authors: Orakhelashvili Alexander
Published: September 2021

The argument that the operation of the international legal system depends on political factors is to many a truism requiring little clarification or verification. But what does the operation of the system of positive international law do to international political processes? Even if it is politics and not law which primarily guides activities and decisions of States, how far could sheer politics get States in achieving their political goals? This paper focuses on three episodes—two historical and one current—about the political life of treaties involving high political stakes, and shows that the viability of foreign policies of States may be more dependent on the ways in which the system of positive international law works than is that system dependent on political agenda pursued by any State or group of States.
Fractional Sailfish Optimizer with Deep Convolution Neural Network for Compressive Sensing Based Magnetic Resonance Image Reconstruction
Authors: Kumar Penta Anil , Gunasundari R , Aarthi R
Published: September 2021

Magnetic resonance image (MRI) is extensively adapted in clinical diagnosis due to its improved representation of changes with soft tissue. The current innovations in compressive sensing (CS) showed that it is viable to precisely reconstruct MRI with K-space data with reduced scanning duration and it takes more time for computation and it is complex to capture the fine details. The CS is capable to minimize the imaging time and it uses compressibility for reconstructing the images. In this paper, a novel deep-learning method is devised for reconstructing images using a set of MRI. Here, MRI acquisition and MRIsub sampling is performed for reducing the size of images to perform improved analysis. Here, a convolution layer is utilized for imitating the process of compressed sampling that can learn the sampling matrix to prevent complex designs. In addition, a convolution layer is utilized to execute the initial reconstruction. In addition, Deep Convolutional Neural Network (Deep CNN) is adapted for image reconstruction. The training of Deep CNN is performed using proposed Fractional Sailfish Optimizer (FSO) algorithm. The proposed FSO is designed by incorporating fractional concepts in Sail fish optimization for tuning the optimal weights of Deep CNN. The proposed FSO-based CSNet outperformed other methods with minimal MSE of 1.877 and maximal PSNR of 45.396 dB.
Classical Absences (1896–2017)
Authors: Jansen Laura
Published: September 2021

When we consider classical receptions in terms of presences, we often think of how antiquity materializes visibly and/or substantially in the fabric of our histories, whether as physical remains or concrete traditions. Yet the search for the classical as a solid, conspicuous phenomenon reveals only one side of the fascinating story of how we can conceive its status and circulation across space and time. This article investigates some key examples across the period 1896–2017, from Argentine author J. L. Borges to British poet-translator Josephine Balmer, which disclose the flip side of this story—that of antiquity’s existence on various levels of dispersal, silence, and occlusion at the intersections of poetry, mythopoeic biography, legend-making, and creative translation. It argues that, in their engagement with the Greco-Roman past, these examples both advance our understanding of absence as a critical idiom and question our sense of how antiquity makes its impact on our world as a ‘classical presence’.
Acute posteromedial papillary muscle rupture secondary to aortic valve endocarditis: a case report
Authors: Marumoto Akira , Shijo Takayuki , Okada Masako , Hasegawa Sinji
Published: September 2021

Background

Acute papillary muscle (PM) rupture due to infective involvement has been recognized as a complication of infective endocarditis. However, there is very limited literature describing the rupture of the posteromedial PM in primary aortic valve endocarditis without aortic root abscess. This report highlights the aetiology of the PM rupture in the setting of primary aortic valve endocarditis and the importance of a multidisciplinary approach.

Case summary

An 81-year-old man without any heart failure symptoms presented with fever and loss of vision in his left eye. Initial echocardiography revealed moderate aortic valve regurgitation due to a perforated right coronary cusp without aortic root abscess, and his blood cultures were positive for Group G Streptococci. During adequate antibiotic therapy, he developed acute severe mitral regurgitation secondary to posteromedial PM rupture. Following emergent aortic and mitral valve replacement using bioprosthetic valves, he made excellent progress on a 6-week course of intravenous antibiotics.

Discussion

The echocardiography and the histological findings suggested that the main cause of PM rupture was most likely a metastatic focus of infection from the aortic valve via a regurgitant jet. Successful treatment of this fatal complication includes early diagnosis and prompt surgical intervention by a multidisciplinary approach.
Temporal fluctuations in zooplankton size, abundance, and taxonomic composition since 1995 in the North Western Mediterranean Sea
Authors: Feuilloley Guillaume , Fromentin Jean-Marc , Saraux Claire , Irisson Jean-Olivier , Jalabert Laetitia , Stemmann Lars
Published: September 2021

In the Gulf of Lions, small pelagic fish have shown reduced body size and body condition after 2007 that would result from changes in zooplankton community. We therefore examined zooplankton density, body size, and taxonomic composition at the closest long-term monitoring station (1995–2019): the coastal Point-B. To cover a broader spectrum of zooplankton community, samples obtained from two nets, the WP2 (200 µm mesh size) and the Regent (690 µm), were analysed with the imaging Zooscan method. One important result was the high stability through time of the zooplankton community. No long-term monotonous trends in density, size, and taxonomic composition were detected. Interannual variations in zooplankton size and density were not significantly correlated to any environmental variable, suggesting the possible importance of biotic interactions. Still, an increase in temperature was followed by a sharp decrease of zooplankton density in 2015, after which only gelatinous groups recovered. No change in the zooplankton community was detected around 2007 to support bottom-up control on small pelagic fish. Whether this derives from different local processes between the Gulf of Lions and the Ligurian Sea cannot be excluded, highlighting the need for simultaneous monitoring of different ecosystem compartments to fully understand the impact of climate change.
The mechanical responses in monopole acoustic LWD and their relation with the output voltage waveform
Authors: Zhang Chao , Chen Da , Hu Hengshan
Published: September 2021

Acoustic logging while drilling (LWD), characterised by simultaneous drilling and logging, is widely used to obtain the elastic parameters of the formation around the borehole. Most published monopole acoustic LWD simulation waveforms are routinely presented as pressure. However, these pressure waveforms disagree with the voltage waveforms recorded in the experiments. Here, to find out the reason of the inconsistent of these two waveforms, both the piezoelectric effect of the transducer and the propagation of the acoustic wave are integrally calculated with the finite-element method, obtaining the voltage waveform as well as the mechanical waveforms. The quantitative comparisons between the mechanical waveforms and the voltage waveform show that the output voltage cannot represent the pressure signal, but a combination of multiple mechanical signals. Based on the piezoelectric equation and the structure of the piezoelectric transducer used in this paper, we formulate the output voltage in terms of the four mechanical quantities, i.e. the radial strain and axial stress of the transducer as well as the acoustic pressure and the radial displacement of the borehole fluid. Furthermore, the contributions of these four mechanical quantities to different wave groups are explored. Finally, the waveforms comparisons after drill collar grooving reveal that the displacement waveform before and after grooving should also be displayed when evaluating the grooving effect instead of only the pressure waveform as in previous studies.
CLRM-06. COMPARISON OF INDIVIDUALIZED ANTI-CANCER THERAPY REGIMENS RECOMMENDED BY A MULTIDISCIPLINARY MOLECULARLY-DRIVEN TUMOR BOARD IN A PEDIATRIC DIPG CLINICAL TRIAL (PNOC003) VERSUS THOSE SELECTED BY THE CNS-TAP TOOL
Authors: Roberts Holly , Ravi Karthik , Schepers Allison , Marini Bernard , Kline Cassie , Mueller Sabine , Koschmann Carl , Franson Andrea
Published: September 2021

Genetic sequencing of diffuse intrinsic pontine gliomas (DIPG) has revealed genomic heterogeneity, fueling an interest in individualized targeted therapies. A feasibility study, PNOC003: Molecular Profiling for Individualized Treatment Plan for DIPG (NCT02274987), was completed within the Pacific Pediatric Neuro-Oncology Consortium in which a multidisciplinary tumor board reviewed molecular and genomic profiling of each participant’s tumor to make targeted therapy recommendations. Separately, our team developed the Central Nervous System Targeted Agent Prediction (CNS-TAP) tool, which combines pre-clinical, clinical, and CNS penetration data with patient-specific genomic information to derive numeric scores for anticancer agents to objectively evaluate these therapies for use in patients with CNS tumors. We hypothesized that agents highly-scored by CNS-TAP would overlap with agents recommended by the PNOC003 tumor board. For each study participant, we retrospectively utilized the genomic profiling report to identify actionable alterations and incorporated these data into CNS-TAP to find the highest-scoring agents. We compared these CNS-TAP-recommended agents with recommendations from the tumor board for each of the 28 PNOC003 participants. Overall, 93% of patients (26/28) had at least one agent recommended by both the tumor board and CNS-TAP. Additionally, 38% of all agents (36/95) chosen by the tumor board were also selected by CNS-TAP. When only molecularly targeted anticancer agents were included in a sub-analysis, 60% of agents (34/57) were recommended by both methods. At present, we are prospectively evaluating the CNS-TAP tool within PNOC008: A Pilot Trial Testing the Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan in Children and Young Adults with High-Grade Glioma (NCT03739372). The CNS-TAP tool recommendations are shared during the PNOC008 molecular tumor board meetings once a consensus treatment recommendation has been reached. Subsequent analyses will focus on any adjustments in therapy decisions within the tumor board that result from the CNS-TAP tool output.