bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Platelet-Rich Fibrin, Calcium Sulfate Hemihydrate, Platelet-Rich Plasma and Resorbable Collagen on Soft Tissue Closure of Extraction Sites
Authors: Yerke Lisa , Jamjoom Amal , Zahid Talal , Cohen Robert
Published: May 2017

Rapid and complete soft tissue healing after tooth extraction minimizes surgical complications and facilitates subsequent implant placement. We used four treatment methods and assessed changes in soft tissue socket closure following tooth extraction in humans. The effects of platelet-rich fibrin-calcium sulfate hemihydrate (PRF-CSH), platelet-rich plasma-calcium sulfate hemihydrate (PRP-CSH), a resorbable collagen dressing (RCD), and no grafting material were compared in a randomized, controlled pilot study with a blinded parallel design (N = 23). Patients with a hopeless tooth scheduled for extraction were randomly assigned to one of the four treatment groups. Socket measurements were obtained immediately after extraction and treatment, as well as after 21 days. There was a significant decrease in the total epithelialized external surface area of the extraction sockets in each group at all time points. However, there were no significant differences in soft tissue closure (p > 0.05) at any time point and PRF-CSH or PRP-CSH did not provide any additional benefit to enhance the soft tissue closure of extraction sockets compared with either RCD or sites without graft.
Development and Initial Assessment of a Patient Education Video about Pharmacogenetics
Authors: Mills Rachel , Ensinger Megan , Callanan Nancy , Haga Susanne
Published: May 2017

As few patient-friendly resources about pharmacogenetics are currently available, we aimed to create and assess a patient educational video on pharmacogenetic testing. A primary literature and resources review was conducted to inform the content and the format of the video. The educational video was then created using a commercially available animation program and pilot tested in focus groups of the general public and by an online survey of pharmacists. Emerging themes from the focus groups and survey indicate a desire for appropriate risk contextualization and specific examples when pharmacogenetic testing may be beneficial. Focus group participants also expressed a preference for a video with live action, and more text to reinforce concepts. Pharmacists generally felt that the video was understandable for patients and relevant for decision-making regarding testing. Using this initial feedback and the identification of important concepts to include in pharmacogenetics educational tools, we plan to revise the video, perform additional evaluations, and publish the video for public use in the future.
Modeling Future Land Cover Changes and Their Effects on the Land Surface Temperatures in the Saudi Arabian Eastern Coastal City of Dammam
Authors: Rahman Muhammad Tauhidur , Aldosary Adel S. , Mortoja Md. Golam
Published: May 2017

Over the past several decades, Saudi cities have experienced rapid urban developments and land use and land cover (LULC) changes. These developments will have numerous short- and long-term consequences including increasing the land surface temperature (LST) of these cities. This study investigated the effects of LULC changes on the LST for the eastern coastal city of Dammam. Using Landsat imagery, the study first detected the LULC using the maximum likelihood classification method and derived the LSTs for the years 1990, 2002, and 2014. Using the classified results, it then modeled the future LULC for 2026 using the Cellular Automata Markov (CAM) model. Finally, using three thematic indices and linear regression analysis, it then modeled the LST for 2026 as well. The built-up area in Dammam increased by 28.9% between 1990 and 2014. During this period, the average LSTs for the LULC classes increased as well, with bare soil and built-up area having the highest LST. By 2026, the urban area is expected to encompass 55% of the city and 98% of the land cover is envisioned to have average LSTs over 41 °C. Such high temperatures will make it difficult for the residents to live in the area.
Alizarin Red S-Confined Layer-By-Layer Films as Redox-Active Coatings on Electrodes for the Voltammetric Determination of L-Dopa
Authors: Takahashi Shigehiro , Suzuki Iwao , Sugawara Tatsuro , Seno Masaru , Minaki Daichi , Anzai Jun-Ichi
Published: May 2017

The preparation of redox-active coatings is a key step in fabricating electrochemical biosensors. To this goal, a variety of coating materials have been used in combination with redox-active compounds. In this study, alizarin red S (ARS) was confined in layer-by-layer (LbL) films composed of poly(ethyleneimine) (PEI) and carboxymethylcellulose (CMC) to study the redox properties. A gold (Au) disc electrode coated with PEI/CMC LbL film was immersed in an ARS solution to uptake ARS into the film. ARS was successfully confined in the LbL film through electrostatic interactions. The cyclic voltammogram (CV) of ARS-confined PEI/CMC film-coated electrodes thus prepared exhibited redox waves in the potential range from −0.5 to −0.7 V originating from 9,10-anthraquinone moiety in ARS, demonstrating that ARS preserves its redox activity in the LbL film. An additional oxidation peak appeared around −0.4 V in the CV recorded in the solution containing phenylboronic acid (PBA), due to the formation of a boronate ester of ARS (ARS-PBA) in the film. The oxidation peak current at −0.4 V decreased upon addition of 3,4-dihydroxyphenylalanine (L-dopa) to the solution. Thus, the results suggest a potential use of the ARS-confined PEI/CMC films for constructing voltammetric sensors for L-dopa.
Cytotoxicity Evaluation of High-Temperature Annealed Nanohydroxyapatite in Contact with Fibroblast Cells
Authors: Szymonowicz Maria , Korczynski Mariusz , Dobrzynski Maciej , Zawisza Katarzyna , Mikulewicz Marcin , Karuga-Kuzniewska Ewa , Zywickab Boguslawa , Rybak Zbigniew , Wiglusz Rafal
Published: May 2017

Biomaterials are substances manufactured for medical purposes in direct contact with the tissues of organisms. Prior to their use, they are tested to determine their usefulness and safety of application. Hydroxyapatites are used in medicine as a bony complement because of their similarity to the natural apatite therein. Thanks to their bioactivity, biocompatibility, stability and non-toxicity hydroxyapatite are the most commonly used materials in osteoimplantology. The use of materials at the nanoscale in medicine or biology may carry the risk of undesirable effects. The aim of the study was to evaluate the cytotoxic effect of high-temperature annealed nanohydroxyapatites on the L929 murine fibroblasts. Nanohydroxyapatites in powder form were obtained by the wet chemistry method: in the temperature range of 800–1000 °C and used for the study. Based on performed studies evaluating the morphology and fibroblast viability, it was found that nanohydroxyapatites show no cytotoxic effects on the L929 cell line.
Structure, Texture and Phases in 3D Printed IN718 Alloy Subjected to Homogenization and HIP Treatments
Authors: Mostafa Ahmad , Picazo Rubio Ignacio , Brailovski Vladimir , Jahazi Mohammad , Medraj Mamoun
Published: May 2017

3D printing results in anisotropy in the microstructure and mechanical properties. The focus of this study is to investigate the structure, texture and phase evolution of the as-printed and heat treated IN718 superalloy. Cylindrical specimens, printed by powder-bed additive manufacturing technique, were subjected to two post-treatments: homogenization (1100 °C, 1 h, furnace cooling) and hot isostatic pressing (HIP) (1160 °C, 100 MPa, 4 h, furnace cooling). The Selective laser melting (SLM) printed microstructure exhibited a columnar architecture, parallel to the building direction, due to the heat flow towards negative z-direction. Whereas, a unique structural morphology was observed in the x-y plane due to different cooling rates resulting from laser beam overlapping. Post-processing treatments reorganized the columnar structure of a strong {002} texture into fine columnar and/or equiaxed grains of random orientations. Equiaxed structure of about 150 µm average grain size, was achieved after homogenization and HIP treatments. Both δ-phase and MC-type brittle carbides, having rough morphologies, were formed at the grain boundaries. Delta-phase formed due to γ″-phase dissolution in the γ matrix, while MC-type carbides nucleates grew by diffusion of solute atoms. The presence of (Nb0.78Ti0.22)C carbide phase, with an fcc structure having a lattice parameter a = 4.43 Å, was revealed using Energy dispersive spectrometer (EDS) and X-ray diffractometer (XRD) analysis. The solidification behavior of IN718 alloy was described to elucidate the evolution of different phases during selective laser melting and post-processing heat treatments of IN718.
Brittle Fracture Behaviors of Large Die Holders Used in Hot Die Forging
Authors: Zhang Weifang , Wang Hongxun , Zhang Jingyu , Dai Wei , Huang Yuanxing
Published: May 2017

Brittle fracture of large forging equipment usually leads to catastrophic consequences. To avoid this kind of accident, the brittle fracture behaviors of a large die holder were studied by simulating the practical application. The die holder is used on the large die forging press, and it is made of 55NiCrMoV7 hot-work tool steel. Detailed investigations including mechanical properties analysis, metallographic observation, fractography, transmission electron microscope (TEM) analysis and selected area electron diffraction (SAED) were conducted. The results reveal that the material generated a large quantity of large size polyhedral M23C6 (M: Fe and Cr mainly) and elongated M3C (M: Fe mainly) carbides along the martensitic lath boundaries when the die holder was recurrently tempered and water-cooled at 250 °C during the service. The large size carbides lead to the material embrittlement and impact toughness degradation, and further resulted in the brittle fracture of the die holder. Therefore, the operation specification must be emphasized to avoid the die holder being cooled by using water, which is aimed at accelerating the cooling.
Effects of Experimental Parameters on the Extraction of Silica and Carbonation of Blast Furnace Slag at Atmospheric Pressure in Low-Concentration Acetic Acid
Authors: Song Kyungsun , Park Sangwon , Kim Wonbaek , Jeon Chi , Ahn Ji-Whan
Published: May 2017

Blast furnace slag (BFS), a calcium-rich industrial byproduct, has been utilized since 2005 as a mineral carbonation feedstock for CO2 sequestration, producing calcium carbonate precipitates. In this study, the conditions for the dissolution of Ca and Si in acetic acid, and subsequent carbonation, were elaborated. For this purpose, the retardation of the polymerization of silicon was attempted by varying the concentration of acetic acid, temperature, and leaching time. An inductively coupled plasma (ICP) analysis revealed that both the Ca and Si dissolved completely within 30 min in 5% acetic acid at room temperature. This high dissolution value can be attributed to the fact that Ca was bound to O rather than to Si, as determined by X-ray photoelectron spectroscopy (XPS). The use of CO2-absorbed monoethanolamine enabled the complete carbonation of BFS at ambient conditions without the need for a pH swing. The presence of dissolved silica was found to affect the polymorphs of the precipitated CaCO3. We believe that this process offers a simple method for manipulating the composites of products obtained by mineral carbonation diminishing the leaching residues.
Handling in the Production of Wire-Based Linked Micro Parts
Authors: Wilhelmi Philipp , Schenck Christian , Kuhfuss Bernd
Published: May 2017

For simplified processing and the enhancement of output rate in multi-stage production, micro parts are handled as linked parts. This contribution discusses handling specific challenges in production based on an exemplary process chain. The examined linked parts consist of spherical elements linked by wire material. Hence, the diameter varies between the wire and part. Nevertheless, the linked parts must be handled accurately. The feed system is an important component too, but special focus is given to the guides in this present study. They must adapt to the diameters of both the parts and the linking wires. Two alternative variants of adaptive guides are presented and investigated under the aspects of precise radial guiding, vibration isolation, damping behavior and friction force.
Control of Acid Generation from Pyrite Oxidation in a Highly Reactive Natural Waste: A Laboratory Case Study
Authors: Zhou Yan , Short Michael D. , Li Jun , Schumann Russell C. , Smart Roger St. C. , Gerson Andrea R. , Qian Gujie
Published: May 2017

Laboratory kinetic leach column (KLC) tests were carried out to define the conditions required to control acid generation from a highly reactive, potentially acid-forming (PAF) iron ore waste rock. It was found that lime addition (0.1 wt % blended) plus either blending of silicates (25 wt % K-feldspar and 25 wt % chlorite), or addition of a non-acid forming (NAF) top cover containing about 10% dolomite (PAF:NAF = 5:1 wt %), when watered/flushed with lime-saturated water, greatly reduced acid generation as compared to the control KLC (PAF alone, watered/flushed with Milli-Q water), but did not result in circum-neutral pH as required for pyrite surface passivation and effective acid and metalliferous drainage (AMD) mitigation. In contrast, the combined use of these treatments—blended lime and silicates with an NAF cover and watering/flushing with lime-saturated water—resulted in leachate pH of 12 (up to 24 weeks). Mass balance calculations for Ca2+ and scanning electron microscopy (SEM) analyses suggest that calcite or gypsum may have formed in the NAF-amended KLCs and lime with added silicate KLC. Although the combined approach in the form trialled here may not be practical or cost-effective, control of a highly reactive natural PAF waste by pyrite surface passivation appears to be possible, and an improved treatment methodology (e.g., slightly increased lime blending without the need for further lime watering/flushing) could usefully be examined in the future.
Total Synthesis and Pharmacological Investigation of Cordyheptapeptide A
Authors: Kumar Suresh , Dahiya Rajiv , Khokra Sukhbir , Mourya Rita , Chennupati Suresh , Maharaj Sandeep
Published: May 2017

The present investigation reports the synthesis of a phenylalanine-rich N-methylated cyclopeptide, cordyheptapeptide A (8), previously isolated from the insect pathogenic fungus Cordyceps sp. BCC 1788, accomplished through the coupling of N-methylated tetrapeptide and tripeptide fragments followed by cyclization of the linear heptapeptide unit. Structure elucidation of the newly synthesized cyclopolypeptide was performed by means of FT-IR, 1H-NMR, 13C-NMR, and fast atom bombardment mass spectrometry (FABMS), and screened for its antibacterial, antidermatophytic, and cytotoxic potential. According to the antimicrobial activity results, the newly synthesized N-Methylated cyclopeptide exhibited potent antibacterial activity against Gram-negative bacteria Pseudomonas aeruginosa and Klebsiella pneumoniae and antifungal activity against dermatophytes Trichophyton mentagrophytes and Microsporum audouinii at a concentration of 6 μg/mL, in comparison to the reference drugs, gatifloxacin and griseofulvin. In addition, cyclopolypeptide 8 displayed suitable levels of cytotoxicity against Dalton’s lymphoma ascites (DLA) and Ehrlich’s ascites carcinoma (EAC) cell lines.
Design, Synthesis, and Biological Activities of Novel Pyrazole Oxime Compounds Containing a Substituted Pyridyl Moiety
Authors: Chen Cuili , Chen Jia , Gu Haiying , Bao Ning , Dai Hong
Published: May 2017

In this paper, in order to find novel biologically active pyrazole oximes, a series of pyrazole oxime compounds bearing a substituted pyridyl unit were prepared. Bioassays showed that some target compounds were found to have good acaricidal activity against Tetranychus cinnabarinus at a concentration of 500 μg/mL, compound 9q especially displayed potent acaricidal activity against T. cinnabarinus when the concentration was reduced to 100 μg/mL. Interestingly, most target compounds possessed excellent insecticidal activities against Oriental armyworm at 500 μg/mL. Moreover, some compounds were active against Aphis medicaginis and Nilaparvata lugens at 500 μg/mL. Additionally, compounds 9b, 9g, 9l, 9p, 9q, 9r, 9s, 9t, 9u, and 9v displayed significant antiproliferative activities against HepG2 cells with IC50 values of 1.53–17.27 μM, better than that of the control 5-fluorouracil (IC50 = 35.67 μM).
Identification of Non-Electrophilic Nrf2 Activators from Approved Drugs
Authors: Zhang Qing-Ye , Chu Xin-Yi , Jiang Ling-Han , Liu Meng-Yuan , Mei Zhi-Ling , Zhang Hong-Yu
Published: May 2017

Oxidative damage can lead to a wide range of diseases. Nrf2 is an important transcription factor that regulates many of the cytoprotective enzymes involved in the oxidative stress response. Therefore, targeting the regulation of Nrf2 activation is one logical and effective strategy to prevent or lower the risk of oxidative stress-related diseases. Until now, most research has focused on electrophilic indirect Nrf2 activators, but the risk of ‘off-target’ effects may be associated with these activators. To find novel small non-electrophilic modulators of Nrf2, we started from chemical agents derived from a connectivity map (cMap) and identified 22 non-electrophilic potential Nrf2-activating drugs through a drug repositioning tactic. By determining the expression changes of antioxidant genes in MCF7 cells that were treated with the potential Nrf2 activators using quantitative real-time polymerase chain reaction RT-PCR (real-time polymerase chain reaction) (qRT-PCR), astemizole was found to have a greater scale of upregulating antioxidant genes NQO1, HO-1, and GCLM than the positive control d,l-sulforaphane, although the testing concentration was lower than that of the control. Astemizole is a good potential redox regulator and deserves more pharmacodynamic experimentation to test and verify its feasibility for use as an Nrf2 activator.
Cellular and Molecular Targets of Resveratrol on Lymphoma and Leukemia Cells
Authors: Frazzi Raffaele , Guardi Manuela
Published: May 2017

Resveratrol (RSV) is a well known chemopreventive molecule featuring anti-cancer properties. Our paper describes the main molecular targets of RSV linked to its antiproliferative activity on lymphoma and leukemia experimental models. It discusses further the most recent and most promising among these molecular targets for a translational application.
Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors
Authors: Haney Staci , Wills Veronica , Wiemer David , Holstein Sarah
Published: May 2017

The enzyme geranylgeranyl diphosphate synthase (GGDPS) catalyzes the synthesis of the 20-carbon isoprenoid geranylgeranyl diphosphate (GGPP). GGPP is the isoprenoid donor for protein geranylgeranylation reactions catalyzed by the enzymes geranylgeranyl transferase (GGTase) I and II. Inhibitors of GGDPS result in diminution of protein geranylgeranylation through depletion of cellular GGPP levels, and there has been interest in GGDPS inhibitors as potential anti-cancer agents. Here we discuss recent advances in the development of GGDPS inhibitors, including insights gained by structure-function relationships, and review the preclinical data that support the continued development of this novel class of drugs.
In Vitro Antioxidant Activity of Idebenone Derivative-Loaded Solid Lipid Nanoparticles
Authors: Montenegro Lucia , Modica Maria , Salerno Loredana , Panico Anna , Crascì Lucia , Puglisi Giovanni , Romeo Giuseppe
Published: May 2017

Idebenone (IDE) has been proposed for the treatment of neurodegenerative diseases involving mitochondria dysfunctions. Unfortunately, to date, IDE therapeutic treatments have not been as successful as expected. To improve IDE efficacy, in this work we describe a two-step approach: (1) synthesis of IDE ester derivatives by covalent linking IDE to other two antioxidants, trolox (IDETRL) and lipoic acid (IDELIP), to obtain a synergic effect; (2) loading of IDE, IDETRL, or IDELIP into solid lipid nanoparticles (SLN) to improve IDE and its esters’ water solubility while increasing and prolonging their antioxidant activity. IDE and its derivatives loaded SLN showed good physico-chemical and technological properties (spherical shape, mean particle sizes 23–25 nm, single peak in the size distribution, ζ potential values −1.76/−2.89 mV, and good stability at room temperature). In vitro antioxidant activity of these SLN was evaluated in comparison with free drugs by means of oxygen radical absorbance capacity (ORAC) test. IDETRL and IDELIP showed a greater antioxidant activity than IDE and encapsulation of IDE and its derivatives into SLN was able to prolong their antioxidant activity. These results suggest that loading IDETRL and IDELIP into SLN could be a useful strategy to improve IDE efficacy.
Structural Characterization of Lignin in Fruits and Stalks of Chinese Quince
Authors: Yin Hui-Shuang , Liu Hua-Min , Liu Yu-Lan
Published: May 2017

Chinese quince (Chaenomeles sinensis) is used in food and pharmaceutical products, but it is seldom eaten as a raw fruit due to its astringent, woody flesh. The structural characterization of lignin fractions from Chinese quince was very important to investigate the structure-activity relationships of lignin. In this investigation, to characterize the structure of lignin in Chinese quince fruits, the milled wood lignin sample was isolated from the fruits (FMWL) and the chemical structure of FMWL was investigated by sugar analysis, FT-IR, GPC, pyrolysis-GC/MS analysis, UV spectra analysis, thermogravimetric analysis (TGA), and advanced NMR spectroscopic techniques. In addition, the lignin fraction from the stalk of Chinese quince (SMWL) was also prepared for comparison to obtained more information of lignin structure in the fruits. The results showed that the two lignin fractions isolated from fruit and stalk of Chinese quince exhibited different structural features. The two MWL samples were mainly composed of β-O-4 ether bonds, β-5 and β-β′ carbon-carbon linkages in the lignin structural units. Compared to the SMWL, the FMWL fraction had the higher S/G ratio and more carbohydrates linkages. The predominant carbohydrates associated with FMWL and SMWL fractions were glucans-type hemicelluloses and xylan-type hemicelluloses, respectively. Understanding the structure of lignin could give insight into the properties of the lignin and enable the food processing industry to separate lignin more efficiently.
Synthesis and Free Radical Scavenging Activity of New Hydroxybenzylidene Hydrazines
Authors: Sersen Frantisek , Gregan Fridrich , Kotora Peter , Kmetova Jarmila , Filo Juraj , Loos Dusan , Gregan Juraj
Published: May 2017

Hydroxybenzylidene hydrazines exhibit a wide spectrum of biological activities. Here, we report synthesis and free radical scavenging activity of nine new N-(hydroxybenzylidene)-N′-[2,6-dinitro-4-(trifluoromethyl)]phenylhydrazines. The chemical structures of these compounds were confirmed by 1H-NMR, 13C-NMR, 19F-NMR, IR spectroscopy, LC-MS, and elemental analysis. The prepared compounds were tested for their activity to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl radical (GOR), and 2,2′-azino-bis(3-ethylbenzothiazoline)-6-sulphonic acid (ABTS) radicals. The free radical scavenging activity expressed as SC50 values of these compounds varied in a wide range, from a strong to no radical scavenging effect. The most effective radical scavengers were hydroxybenzylidene hydrazines containing three hydroxyl groups in the benzylidene part of their molecules. The prepared compounds were also tested for their activity to inhibit photosynthetic electron transport in spinach chloroplasts. IC50 values of these compounds varied in wide range, from an intermediate to no inhibitory effect.
Combined Treatment with Hyaluronic Acid and Mesalamine Protects Rats from Inflammatory Bowel Disease Induced by Intracolonic Administration of Trinitrobenzenesulfonic Acid
Authors: Chiu Chih-Tung , Kuo Sheng-Nan , Hung Shao-Wen , Yang Cheng-Yao
Published: May 2017

Drugs such as mesalamine (5-ASA) are currently recommended for the treatment of inflammatory bowel disease (IBD). To reduce the frequency of their administration and improve their therapeutic effect, this study investigated the adhesion efficacy, wound healing promotion, and decrease in inflammation in ulcers in the colonic tissue of rats with colitis after combined treatment with hyaluronic acid (HA) and 5-ASA (IBD98-M). HA-fluoresceinamine (FL) conjugates successfully adhered to the mucosal layer and were conjugated in the vascular tissue. In addition, macroscopic and microscopic observations indicated that colonic injuries reduced significantly after treatment with IBD98-M. Compared with PBS and 5-ASA treatment alone, treatment with IBD98-M more effectively reduced bowel inflammation and promoted colonic mucosal healing in TNBS-induced colitis. IBD98-M treatment also reduced myeloperoxidase activity and the expression levels of cyclooxygenase 2 and tumor necrosis factor-αin the colitis tissue. In conclusion, IBD98-M treatment strongly promoted wound healing in colonic injuries and significantly inhibited MPO activity in the inflamed colon tissue of rats. Combined treatment with HA and 5-ASA can accelerate wound healing and reduce inflammatory reaction in rat colitis.
Selected Risk Nutritional Factors for Chemotherapy-Induced Polyneuropathy
Authors: Grim Jiri , Ticha Alena , Hyspler Radomir , Valis Martin , Zadak Zdenek
Published: May 2017

The present study seeks to identify the nutritional risk factors involved in the development of neuropathies induced by chemotherapeutic treatments. Unlike the gastrointestinal or hematological adverse effects of chemotherapy there is no protective treatment strategy for polyneuropathy. The aim of this study was to find possible deficiencies in nutritional factors, which can be used for supplementation in the future for prevention of chemotherapy-induced neuropathy development. We analyzed 70 patients undergoing paclitaxel chemotherapy and evaluated the risk factors involved in chemotherapy-induced peripheral neuropathy (CIPN). Several risk factors were considered in the development of CIPN, including deficiency of vitamin B1, B6, and D and fatty acids. The occurrence of CIPN complication in 60% cases was observed. We found significant differences in vitamin D and saturated fatty acid concentration. Vitamin D levels in the group without CIPN were estimated to be 38.2 (24.95, 47.63) nmol/L, whereas in the group with CIPN it was determined to be 25.6 (19.7, 32.55) nmol/L, p = 0.008. The level of total saturated fatty acids in the group without CIPN was of 32.613 Area % (31.322; 36.262), whereas in the group with CIPN it was of 34.209 Area % (32.86; 39.386), p = 0.01. The obtained results suggest a diet lower in saturated fatty acid content during chemotherapy. The most significant finding was that supplementation of vitamin D before chemotherapy could be an efficient neuroprotective in CIPN prophylaxis, as significantly lower levels 25OH derivative of vitamin D were observed in the CIPN group throughout the study period.
Dialysis Procedures Alter Metabolic Conditions
Authors: Stegmayr Bernd
Published: May 2017

A progressive chronic kidney disease results in retention of various substances that more or less contribute to dysfunction of various metabolic systems. The accumulated substances are denominated uremic toxins. Although many toxins remain undetected, numerous newly defined toxins participate in the disturbance of food breakdown. In addition, toxic effects may downregulate other pathways, resulting in a reduced ability of free fatty acid breakdown by lipoprotein lipase (LPL) and hepatic lipase (HL). Dialysis may even worsen metabolic functions. For LPL and HL, the use of heparin and low molecular weight heparin as anticoagulation during hemodialysis (HD) initiate a loss of these enzymes from their binding sites and degradation, causing a temporary dysregulation in triglyceride breakdown. This lack of function will cause retention of the triglyceride containing lipids for at least 8 h. In parallel, the breakdown into free fatty acids is limited, as is the energy supply by them. This is repeated thrice a week for a normal HD patient. In addition, dialysis will cause a loss of amino acids and disturb glucose metabolism depending on the dialysates used. The addition of glucose in the dialysate may support oxidation of carbohydrate and the retention of Amadori products and subsequent tissue alterations. To avoid these effects, it seems necessary to further study the effects of anticoagulation in HD, the extent of use of glucose in the dialysate, and the supplementation of amino acids.
Toxoplasma gondii in the Food Supply
Authors: Hussain Malik , Stitt Victoria , Szabo Elizabeth , Nelan Bruce
Published: May 2017

Toxoplasmosis is caused by infection with the protozoan parasite Toxoplasma gondii. Infections are usually either asymptomatic or develop mild symptoms that are self-limited, but infections in immunosuppressed persons can be severe. Infections in pregnant women can cause serious health problems in the child such as mental retardation and blindness. Infection with T. gondii in immunocompetent adults can lead to impaired eyesight. Toxoplasmosis has ranked very highly in two studies of death and disability attributable to foodborne pathogens. The consumption of raw or undercooked meat containing T. gondii tissue cysts and the consumption of raw vegetables or water contaminated with T. gondii oocysts from cat feces is most frequently associated with human illness. The risk of acquiring a Toxoplasma infection via food varies with cultural and eating habits in different human populations.
Volume Hologram Formation in SU-8 Photoresist
Authors: Sabel Tina
Published: May 2017

In order to further understand the mechanism of volume hologram formation in photosensitive polymers, light-induced material response is analyzed in commonly used epoxy-based negative photoresist Epon SU-8. For this purpose, time-resolved investigation of volume holographic grating growth is performed in the SU-8 based host–guest system and in the pure SU-8 material, respectively. The comparison of grating growth curves from doped and undoped system allows us to draw conclusions on the impact of individual components on the grating formation process. The successive formation of transient absorption as well as phase gratings in SU-8 is observed. Influence of exposure duration and UV flood cure on the grating growth are investigated. Observed volume holographic grating formation in SU-8 can be explained based on the generation and subsequent diffusion of photoacid as well as time-delayed polymerization of exposed and unexposed areas.
Performance and Kinetics Study of Self-Repairing Hydroxyl-Terminated Polybutadiene Binders Based on the Diels–Alder Reaction
Authors: Liang Chuyao , Li Jie , Xia Min , Li Guoping , Luo Yunjun
Published: May 2017

Based on the Diels–Alder reaction and hydroxyl-terminated polybutadiene (HTPB) binders of solid propellants, two novel compounds—furfuryl-terminated polybutadiene (FTPB) and trifurfuryl propane (TFP)—were designed and synthesized, and their structures were characterized. A new kind of reversible Diels–Alder reaction system was formed by FTPB as main resin, N,N′-1,3-phenylenedimaleimide (PDMI) as curing agent and TFP as chain extender. The results showed that this system had good mechanical properties with a tensile strength of 1.76 MPa and a tensile strain of 284% after curing, and the repair efficiency of the crack was 88%. Therefore, it could be used as a novel binder of energetic materials such as solid propellant and PBX explosives to provide them with self-repairing characteristics and improve the reliability for application.
State Space Models and the Kalman-Filter in Stochastic Claims Reserving: Forecasting, Filtering and Smoothing
Authors: Chukhrova Nataliya , Johannssen Arne
Published: May 2017

This paper gives a detailed overview of the current state of research in relation to the use of state space models and the Kalman-filter in the field of stochastic claims reserving. Most of these state space representations are matrix-based, which complicates their applications. Therefore, to facilitate the implementation of state space models in practice, we present a scalar state space model for cumulative payments, which is an extension of the well-known chain ladder (CL) method. The presented model is distribution-free, forms a basis for determining the entire unobservable lower and upper run-off triangles and can easily be applied in practice using the Kalman-filter for prediction, filtering and smoothing of cumulative payments. In addition, the model provides an easy way to find outliers in the data and to determine outlier effects. Finally, an empirical comparison of the scalar state space model, promising prior state space models and some popular stochastic claims reserving methods is performed.
A Dark Target Algorithm for the GOSAT TANSO-CAI Sensor in Aerosol Optical Depth Retrieval over Land
Authors: Zhong Guosheng , Wang Xiufeng , Guo Meng , Tani Hiroshi , Chittenden Anthony , Yin Shuai , Sun Zhongyi , Matsumura Shinji
Published: May 2017

Cloud and Aerosol Imager (CAI) onboard the Greenhouse Gases Observing Satellite (GOSAT) is a multi-band sensor designed to observe and acquire information on clouds and aerosols. In order to retrieve aerosol optical depth (AOD) over land from the CAI sensor, a Dark Target (DT) algorithm for GOSAT CAI was developed based on the strategy of the Moderate Resolution Imaging Spectroradiometer (MODIS) DT algorithm. When retrieving AOD from satellite platforms, determining surface contributions is a major challenge. In the MODIS DT algorithm, surface signals in the visible wavelengths are estimated based on the relationships between visible channels and shortwave infrared (SWIR) near the 2.1 µm channel. However, the CAI only has a 1.6 µm band to cover the SWIR wavelengths. To resolve the difficulties in determining surface reflectance caused by the lack of 2.1 μm band data, we attempted to analyze the relationship between reflectance at 1.6 µm and at 2.1 µm. We did this using the MODIS surface reflectance product and then connecting the reflectances at 1.6 µm and the visible bands based on the empirical relationship between reflectances at 2.1 µm and the visible bands. We found that the reflectance relationship between 1.6 µm and 2.1 µm is typically dependent on the vegetation conditions, and that reflectances at 2.1 µm can be parameterized as a function of 1.6 µm reflectance and the Vegetation Index (VI). Based on our experimental results, an Aerosol Free Vegetation Index (AFRI2.1)-based regression function connecting the 1.6 µm and 2.1 µm bands was summarized. Under light aerosol loading (AOD at 0.55 µm < 0.1), the 2.1 µm reflectance derived by our method has an extremely high correlation with the true 2.1 µm reflectance (r-value = 0.928). Similar to the MODIS DT algorithms (Collection 5 and Collection 6), a CAI-applicable approach that uses AFRI2.1 and the scattering angle to account for the visible surface signals was proposed. It was then applied to the CAI sensor for AOD retrieval; the retrievals were validated by comparisons with ground-level measurements from Aerosol Robotic Network (AERONET) sites. Validations show that retrievals from the CAI have high agreement with the AERONET measurements, with an r-value of 0.922, and 69.2% of the AOD retrieved data falling within the expected error envelope of ± (0.1 + 15% AODAERONET).
Satellite Monitoring the Spatial-Temporal Dynamics of Desertification in Response to Climate Change and Human Activities across the Ordos Plateau, China
Authors: Guo Qiang , Fu Bihong , Shi Pilong , Cudahy Thomas , Zhang Jing , Xu Huan
Published: May 2017

The Ordos Plateau, a typical semi-arid area in northern China, has experienced severe wind erosion events that have stripped the agriculturally important finer fraction of the topsoil and caused dust events that often impact the air quality in northern China and the surrounding regions. Both climate change and human activities have been considered key factors in the desertification process. This study used multi-spectral Landsat Thematic Mapper (TM), Enhanced Thematic Mapper Plus (ETM+) and Operational Land Imager (OLI) remote sensing data collected in 2000, 2006, 2010 and 2015 to generate a temporal series of the modified soil-adjusted vegetation index (MSAVI), bare soil index (BSI) and albedo products in the Ordos Plateau. Based on these satellite products and the decision tree method, we quantitatively assessed the desertification status over the past 15 years since 2000. Furthermore, a quantitative method was used to assess the roles of driving forces in desertification dynamics using net primary productivity (NPP) as a commensurable indicator. The results showed that the area of non-desertification land increased from 6647 km2 in 2000 to 15,961 km2 in 2015, while the area of severe desertification land decreased from 16,161 km2 in 2000 to 8,331 km2 in 2015. During the period 2006–2015, the effect of human activities, especially the ecological recovery projects implemented in northern China, was the main cause of desertification reversion in this region. Therefore, ecological recovery projects are still required to promote harmonious development between nature and human society in ecologically fragile regions like the Ordos Plateau.
Evaluating Urban Land Carrying Capacity Based on the Ecological Sensitivity Analysis: A Case Study in Hangzhou, China
Authors: Tsou Jinyeu , Gao Yanfei , Zhang Yuanzhi , Genyun Sun , Ren Jinchang , Li Yu
Published: May 2017

Abstract: In this study, we present the evaluation of urban land carrying capacity (ULCC) based on an ecological sensitivity analysis. Remote sensing data and geographic information system (GIS) technology are employed to analyze topographic conditions, land-use types, the intensity of urban development, and ecological environmental sensitivity to create reasonable evaluation indicators to analyze urban land carrying capacity based on ecological sensitivity in the rapidly developing megacity of Hangzhou, China. In the study, ecological sensitivity is grouped into four levels: non-sensitive, lightly sensitive, moderately sensitive, and highly sensitive. The results show that the ecological sensitivity increases progressively from the center to the periphery. The results also show that ULCC is determined by ecologically sensitive levels and that the ULCC is categorized into four levels. Even though it is limited by the four levels, the ULCC still has a large margin if compared with the current population numbers. The study suggests that the urban ecological environment will continue to sustain the current population size in the short-term future. However, it is necessary to focus on the protection of distinctive natural landscapes so that decision makers can adjust measures for ecological conditions to carry out the sustainable development of populations, natural resources, and the environment in megacities like Hangzhou, China.
Global Analysis of Bioclimatic Controls on Ecosystem Productivity Using Satellite Observations of Solar-Induced Chlorophyll Fluorescence
Authors: Madani Nima , Kimball John , Jones Lucas , Parazoo Nicholas , Guan Kaiyu
Published: May 2017

Ecosystem productivity models rely on regional climatic information to estimate temperature and moisture constraints influencing plant growth. However, the productivity response to these environmental factors is uncertain at the global scale and has largely been defined using limited observations from sparse monitoring sites, including carbon flux towers. Recent studies have shown that satellite observations of Solar-Induced chlorophyll Fluorescence (SIF) are highly correlated with ecosystem Gross Primary Productivity (GPP). Here, we use a relatively long-term global SIF observational record from the Global Ozone Monitoring Experiment-2 (GOME-2) sensors to investigate the relationships between SIF, used as a proxy for GPP, and selected bio-climatic factors constraining plant growth at the global scale. We compared the satellite SIF retrievals with collocated GPP observations from a global network of tower carbon flux monitoring sites and surface meteorological data from model reanalysis, including soil moisture, Vapor Pressure Deficit (VPD), and minimum daily air temperature (Tmin). We found strong correspondence (R2 > 80%) between SIF and GPP monthly climatologies for tower sites characterized by mixed, deciduous broadleaf, evergreen needleleaf forests, and croplands. For other land cover types including savanna, shrubland, and evergreen broadleaf forest, SIF showed significant but higher variability in correlations between sites. In order to analyze temperature and moisture related effects on ecosystem productivity, we divided SIF by photosynthetically active radiation (SIFp) and examined partial correlations between SIFp and the climatic factors across a global range of flux tower sites, and over broader regional and global extents. We found that productivity in arid ecosystems is more strongly controlled by soil water content to an extent that soil moisture explains a higher proportion of the seasonal cycle in productivity than VPD. At the global scale, ecosystem productivity is affected by joint climatic constraint factors so that VPD, Tmin, and soil moisture were significant (p < 0.05) controls over 60, 59, and 35 percent of the global domain, respectively. Our study identifies and confirms dominant climate control factors influencing productivity at the global scale indicated from satellite SIF observations. The results are generally consistent with climate response characteristics indicated from sparse global tower observations, while providing more extensive coverage for verifying and refining global carbon and climate model assumptions and predictions.
Optimization of a Deep Convective Cloud Technique in Evaluating the Long-Term Radiometric Stability of MODIS Reflective Solar Bands
Authors: Mu Qiaozhen , Wu Aisheng , Xiong Xiaoxiong , Doelling David , Angal Amit , Chang Tiejun , Bhatt Rajendra
Published: May 2017

MODIS reflective solar bands are calibrated on-orbit using a solar diffuser and near-monthly lunar observations. To monitor the performance and effectiveness of the on-orbit calibrations, pseudo-invariant targets such as deep convective clouds (DCCs), Libya-4, and Dome-C are used to track the long-term stability of MODIS Level 1B product. However, the current MODIS operational DCC technique (DCCT) simply uses the criteria set for the 0.65-µm band. We optimize several critical DCCT parameters including the 11-µm IR-band Brightness Temperature (BT11) threshold for DCC identification, DCC core size and uniformity to help locate DCCs at convection centers, data collection time interval, and probability distribution function (PDF) bin increment for each channel. The mode reflectances corresponding to the PDF peaks are utilized as the DCC reflectances. Results show that the BT11 threshold and time interval are most critical for the Short Wave Infrared (SWIR) bands. The Bidirectional Reflectance Distribution Function model is most effective in reducing the DCC anisotropy for the visible channels. The uniformity filters and PDF bin size have minimal impacts on the visible channels and a larger impact on the SWIR bands. The newly optimized DCCT will be used for future evaluation of MODIS on-orbit calibration by MODIS Characterization Support Team.
The Use of Unmanned Aerial Systems in Marine Mammal Research
Authors: Fiori Lorenzo , Doshi Ashray , Martinez Emmanuelle , Orams Mark B. , Bollard-Breen Barbara
Published: May 2017

Unmanned aerial systems (UAS), commonly referred to as drones, are finding applications in several ecological research areas since remotely piloted aircraft (RPA) technology has ceased to be a military prerogative. Fixed-wing RPA have been tested for line transect aerial surveys of geographically dispersed marine mammal species. Despite many advantages, their systematic use is far from a reality. Low altitude, long endurance systems are still highly priced. Regulatory bodies also impose limitations while struggling to cope with UAS rapid technological evolution. In contrast, small vertical take-off and landing (VTOL) UAS have become increasingly affordable but lack the flight endurance required for long-range aerial surveys. Although this issue and civil aviation regulations prevent the use of VTOL UAS for marine mammal abundance estimation on a large scale, recent studies have highlighted other potential applications. The present note represents a general overview on the use of UAS as a survey tool for marine mammal studies. The literature pertaining to UAS marine mammal research applications is considered with special concern for advantages and limitations of the survey design. The use of lightweight VTOL UAS to collect marine mammal behavioral data is also discussed.
LOCALI: Calibration-Free Systematic Localization Approach for Indoor Positioning
Authors: Ali Muhammad , Hur Soojung , Park Yongwan
Published: May 2017

Recent advancements in indoor positioning systems are based on infrastructure-free solutions, aimed at improving the location accuracy in complex indoor environments without the use of specialized resources. A popular infrastructure-free solution for indoor positioning is a calibration-based positioning, commonly known as fingerprinting. Fingerprinting solutions require extensive and error-free surveys of environments to build radio-map databases, which play a key role in position estimation. Fingerprinting also requires random updates of the database, when there are significant changes in the environment or a decrease in the accuracy. The calibration of the fingerprinting database is a time-consuming and laborious effort that prevents the extensive adoption of this technique. In this paper, we present a systematic LOCALIzation approach, “LOCALI”, for indoor positioning, which does not require a calibration database and extensive updates. The LOCALI exploits the floor plan/wall map of the environment to estimate the target position by generating radio maps by integrating path-losses over certain trajectories in complex indoor environments, where triangulation using time information or the received signal strength level is highly erroneous due to the fading effects caused by multi-path propagation or absorption by environmental elements or varying antenna alignment. Experimental results demonstrate that by using the map information and environmental parameters, a significant level of accuracy in indoor positioning can be achieved. Moreover, this process requires considerably lesser effort compared to the calibration-based techniques.
Socioeconomic Factors of Immigrants’ Location Choices. Evidence for the South of Europe
Authors: Martín Martín José , Jiménez Aguilera Juan
Published: May 2017

This paper takes as a reference, empirical analyses conducted in northern European countries and the United States which associate socioeconomic factors to the location patterns of immigrants. It has been suggested that the socioeconomic context of southern Europe could impact immigrants’ location choices. We analyze data on the location of immigrants in municipalities of the Andalusian region in southern Spain with respect to the factors that most influence immigrants’ location preferences as discussed in the literature: a pre-existing immigrant community, economic dynamism, population size and other scarcely investigated factors such as the territorial characteristics of the municipality and its productive structure. We conclude that immigrant location patterns in Andalusia are very similar to those found in geographical areas outside Spain, with the exception of specific characteristics related to the social and labor model of the region.