bluuebunny/crossref_metadata_2025 huggingface dataset:
Context awareness in process monitoring of additive manufacturing using a digital twin
Authors: Reisch Raven T. , Hauser Tobias , Lutz Benjamin , Tsakpinis Alexandros , Winter Dominik , Kamps Tobias , Knoll Alois
Published: January 2022

Wire Arc Additive Manufacturing allows the cost-effective manufacturing of customized, large-scale metal parts. As the post-process quality assurance of large parts is costly and time-consuming, process monitoring is inevitable. In the present study, a context-aware monitoring solution was investigated by integrating machine, temporal, and spatial context in the data analysis. By analyzing the voltage patterns of each cycle in the oscillating cold metal transfer process with a deep neural network, temporal context was included. Spatial context awareness was enabled by building a digital twin of the manufactured part using an Octree as spatial indexing data structure. By means of the spatial context awareness, two quality metrics—the defect expansion and the local anomaly density—were introduced. The defect expansion was tracked in-process by assigning detected defects to the same defect cluster in case of spatial correlation. The local anomaly density was derived by defining a spherical region of interest which enabled the detection of aggregations of anomalies. By means of the context aware monitoring system, defects were detected in-process with a higher sensitivity as common defect detectors for welding applications, showing less false-positives and false-negatives. A quantitative evaluation of defect expansion and densities of various defect types such as pore nests was enabled.
p-Hyperbolicity of homotopy groups via K-theory
Authors: Boyde Guy
Published: January 2022

We show that $$S^n \vee S^m$$

S
n

∨

S
m

is $${\mathbb {Z}}/p^r$$

Z
/

p
r

-hyperbolic for all primes p and all $$r \in {\mathbb {Z}}^+$$

r
∈

Z

+

, provided $$n,m \ge 2$$

n
,
m
≥
2

, and consequently that various spaces containing $$S^n \vee S^m$$

S
n

∨

S
m

as a p-local retract are $${\mathbb {Z}}/p^r$$

Z
/

p
r

-hyperbolic. We then give a K-theory criterion for a suspension $$\Sigma X$$

Σ
X

to be p-hyperbolic, and use it to deduce that the suspension of a complex Grassmannian $$\Sigma Gr_{k,n}$$

Σ
G

r

k
,
n

is p-hyperbolic for all odd primes p when $$n \ge 3$$

n
≥
3

and $$0<k<n$$

0
<
k
<
n

. We obtain similar results for some related spaces.
Understanding gluten-free bread ingredients during ohmic heating: function, effect and potential application for breadmaking
Authors: Waziiroh Elok , Schoenlechner Regine , Jaeger Henry , Brusadelli Gloria , Bender Denisse
Published: January 2022

Due to the absence of gluten, several challenges arise during gluten-free (GF) bread baking, affecting the mid-and-end-product quality. The main approach to overcome this issue is to combine certain functional ingredients and additives, to partially simulate wheat bread properties. In addition, the optimization of the baking process may contribute to improved product quality. A recent and very promising alternative to conventional baking is the use of ohmic heating (OH). Due to its volumetric and uniform heating principle, crumb development during baking and consequently bread volume is improved, which enhances the overall GF bread quality. Depending on the GF formulation, critical factors such as the electrical conductivity and viscosity of the batter may vary, which have a significant effect on the OH process performance. Therefore, this review attempts to provide a deeper understanding of the functionality of GF bread ingredients and how these may affect critical parameters during the OH processing.
Chewing gum reduces visually induced motion sickness
Authors: Kaufeld Mara , De Coninck Katharina , Schmidt Jennifer , Hecht Heiko
Published: January 2022

Visually induced motion sickness (VIMS) is a common side-effect of exposure to virtual reality (VR). Its unpleasant symptoms may limit the acceptance of VR technologies for training or clinical purposes. Mechanical stimulation of the mastoid and diverting attention to pleasant stimuli-like odors or music have been found to ameliorate VIMS. Chewing gum combines both in an easy-to-administer fashion and should thus be an effective countermeasure against VIMS. Our study investigated whether gustatory-motor stimulation by chewing gum leads to a reduction of VIMS symptoms. 77 subjects were assigned to three experimental groups (control, peppermint gum, and ginger gum) and completed a 15-min virtual helicopter flight, using a VR head-mounted display. Before and after VR exposure, we assessed VIMS with the Simulator Sickness Questionnaire (SSQ), and during the virtual flight once every minute with the Fast Motion Sickness Scale (FMS). Chewing gum (peppermint gum:M = 2.44, SD = 2.67; ginger gum:M = 2.57, SD = 3.30) reduced the peak FMS scores by 2.05 (SE = 0.76) points as compared with the control group (M = 4.56, SD = 3.52),p < 0.01,d = 0.65. Additionally, taste ratings correlated slightly negatively with both the SSQ and the peak FMS scores, suggesting that pleasant taste of the chewing gum is associated with less VIMS. Thus, chewing gum may be useful as an affordable, accepted, and easy-to-access way to mitigate VIMS in numerous applications like education or training. Possible mechanisms behind the effect are discussed.
Management of herpesvirus reactivations in patients with solid tumours and hematologic malignancies: update of the Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO) on herpes simplex virus type 1, herpes simplex virus type 2, and varicella zoster virus
Authors: Henze Larissa , Buhl Christoph , Sandherr Michael , Cornely Oliver A. , Heinz Werner J. , Khodamoradi Yascha , Kiderlen Til Ramon , Koehler Philipp , Seidler Alrun , Sprute Rosanne , Schmidt-Hieber Martin , von Lilienfeld-Toal Marie
Published: January 2022

Clinical reactivations of herpes simplex virus or varicella zoster virus occur frequently among patients with malignancies and manifest particularly as herpes simplex stomatitis in patients with acute leukaemia treated with intensive chemotherapy and as herpes zoster in patients with lymphoma or multiple myeloma. In recent years, knowledge on reactivation rates and clinical manifestations has increased for conventional chemotherapeutics as well as for many new antineoplastic agents. This guideline summarizes current evidence on herpesvirus reactivation in patients with solid tumours and hematological malignancies not undergoing allogeneic or autologous hematopoietic stem cell transplantation or other cellular therapy including diagnostic, prophylactic, and therapeutic aspects. Particularly, strategies of risk adapted pharmacological prophylaxis and vaccination are outlined for different patient groups. This guideline updates the guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO) from 2015 “Antiviral prophylaxis in patients with solid tumours and haematological malignancies” focusing on herpes simplex virus and varicella zoster virus.
More than a feeling?—Overruling the preoperatively templated offset option leads to a minor offset increase in short stem total hip arthroplasty
Authors: Luger Matthias , Stadler Christian , Hochgatterer Rainer , Allerstorfer Jakob , Gotterbarm Tobias , Klasan Antonio
Published: January 2022

Purpose

Short stems are increasingly used in total hip arthroplasty (THA) because of advantages in bone and soft tissue preservation and reconstruction of hip geometry. Digital templating is essential in determining the correct offset option and stem size in THA. However, the preoperative template sizes might be intraoperatively overruled.

Patients and methods

We evaluated the effect of intraoperative overruling of the preoperatively templated offset option of a short curved stem on hip offset, leg length, implant positioning, and femoral canal fill index. The overruling was performed in case of intraoperative instability, telescoping, or both. A series of 1052 consecutive THAs with a cementless short curved stem and press-fit cup was retrospectively screened. One hundred patients with unilateral THA and a contralateral native and morphologically healthy hip as a reference met the inclusion criteria. Measurements were carried out on preoperative and 3 months anterior–posterior postoperative radiographs. Patients were divided according to the overruling by offset option or stem size.

Results

Hip offset was increased in all groups, but only with significant increase if an offset option + 1 was used intraoperatively (p = 0.025). LLD was restored without significance in all groups (p = 0.323; p = 0.157).

Conclusion

Intraoperative overruling of the preoperative digital template in cementless short stem total hip arthroplasty results in an increase of hip offset compared to a contralateral healthy hip. However, the increase is marginal and clearly under 5 mm compared to the contralateral healthy hip.
Clinical Outcomes of Patients with Combined Idiopathic Pulmonary Fibrosis and Emphysema in the IPF-PRO Registry
Authors: Kim Hyun J. , Snyder Laurie D. , Neely Megan L. , Hellkamp Anne S. , Hotchkin David L. , Morrison Lake D. , Bender Shaun , Leonard Thomas B. , Culver Daniel A. ,   the IPF-PRO™ Registry investigators
Published: January 2022

Purpose

To assess the impact of concomitant emphysema on outcomes in patients with idiopathic pulmonary fibrosis (IPF).

Methods

The IPF-PRO Registry is a US registry of patients with IPF. The presence of combined pulmonary fibrosis and emphysema (CPFE) at enrollment was determined by investigators’ review of an HRCT scan. Associations between emphysema and clinical outcomes were analyzed using Cox proportional hazards models.

Results

Of 934 patients, 119 (12.7%) had CPFE. Compared with patients with IPF alone, patients with CPFE were older (median 72 vs 70 years); higher proportions were current/former smokers (88.2% vs 63.7%), used oxygen with activity (49.6% vs 31.9%) or at rest (30.8% vs 18.4%), had congestive heart failure (13.6% vs 4.8%) and had prior respiratory hospitalization (25.0% vs 16.7%); they had higher FVC (median 71.8 vs 69.4% predicted) and lower DLco (median 35.3 vs 43.6% predicted). In patients with CPFE and IPF alone, respectively, at 1 year, rates of death or lung transplant were 17.5% (95% CI: 11.7, 25.8) and 11.2% (9.2, 13.6) and rates of hospitalization were 21.6% (14.6, 29.6) and 20.6% (17.9, 23.5). There were no significant associations between emphysema and any outcome after adjustment for baseline variables. No baseline variable predicted outcomes better in IPF alone than in CPFE.

Conclusion

Approximately 13% of patients in the IPF-PRO Registry had CPFE. Physiologic characteristics and comorbidities of patients with CPFE differed from those of patients with IPF alone, but the presence of emphysema did not drive outcomes after adjustment for baseline covariates.

Trial registration

ClinicalTrials.gov, NCT01915511; registered August 5, 2013.
Innovative therapeutic concepts of progressive multifocal leukoencephalopathy
Authors: Möhn Nora , Grote-Levi Lea , Hopfner Franziska , Eiz-Vesper Britta , Maecker-Kolhoff Britta , Warnke Clemens , Sühs Kurt-Wolfram , Wattjes Mike P. , Höglinger Günter U. , Skripuletz Thomas
Published: January 2022

Progressive multifocal leukoencephalopathy (PML) is an opportunistic viral disease of the brain—caused by human polyomavirus 2. It affects patients whose immune system is compromised by a corresponding underlying disease or by drugs. Patients with an underlying lymphoproliferative disease have the worst prognosis with a mortality rate of up to 90%. Several therapeutic strategies have been proposed but failed to show any benefit so far. Therefore, the primary therapeutic strategy aims to reconstitute the impaired immune system to generate an effective endogenous antiviral response. Recently, anti-PD-1 antibodies and application of allogeneic virus-specific T cells demonstrated promising effects on the outcome in individual PML patients. This article aims to provide a detailed overview of the literature with a focus on these two treatment approaches.
Sleep disturbances in ADHD: investigating the contribution of polygenic liability for ADHD and sleep-related phenotypes
Authors: Lewis Katie J. S. , Martin Joanna , Gregory Alice M. , Anney Richard , Thapar Anita , Langley Kate
Published: January 2022

Sleep disturbances are common in attention deficit hyperactivity disorder (ADHD) and associated with poor outcomes. We tested whether, in children with ADHD, (1) polygenic liability for sleep phenotypes is over- or under-transmitted from parents, (2) this liability is linked to comorbid sleep disturbances, and (3) ADHD genetic risk is associated with comorbid sleep disturbances. We derived polygenic scores (PGS) for insomnia, chronotype, sleep duration, and ADHD, in 758 children (5–18 years old) diagnosed with ADHD and their parents. We conducted polygenic transmission disequilibrium tests for each sleep PGS in complete parent–offspring ADHD trios (N = 328) and an independent replication sample of ADHD trios (N = 844). Next, we tested whether insomnia, sleep duration, and ADHD PGS were associated with co-occurring sleep phenotypes (hypersomnia, insomnia, restless sleep, poor sleep quality, and nightmares) in children with ADHD. Children’s insomnia and chronotype PGS did not differ from mid-parent average PGS but long sleep duration PGS were significantly over-transmitted to children with ADHD. This was supported by a combined analysis using the replication sample. Insomnia, sleep duration, and ADHD PGS were not associated with comorbid sleep disturbances. There is weak evidence that children with ADHD over-inherit polygenic liability for longer sleep duration and do not differentially inherit polygenic liability for insomnia or chronotype. There was insufficient evidence that childhood sleep disturbances were driven by polygenic liability for ADHD or sleep traits, suggesting that sleep disturbances in ADHD may be aetiologically different to general population sleep phenotypes and do not index greater ADHD genetic risk burden.
A computational status update for exact rational mixed integer programming
Authors: Eifler Leon , Gleixner Ambros
Published: January 2022

The last milestone achievement for the roundoff-error-free solution of general mixed integer programs over the rational numbers was a hybrid-precision branch-and-bound algorithm published by Cook, Koch, Steffy, and Wolter in 2013. We describe a substantial revision and extension of this framework that integrates symbolic presolving, features an exact repair step for solutions from primal heuristics, employs a faster rational LP solver based on LP iterative refinement, and is able to produce independently verifiable certificates of optimality. We study the significantly improved performance and give insights into the computational behavior of the new algorithmic components. On the MIPLIB 2017 benchmark set, we observe an average speedup of 10.7x over the original framework and 2.9 times as many instances solved within a time limit of two hours.
How Does Fluid Flow Influence Drug Release from Drug Filled Implants?
Authors: King David , McCormick Christopher , McGinty Sean
Published: January 2022

Drug-filled implants (DFIs) have emerged as an innovative approach to control the delivery of drugs. These devices contain the drug within the structure of the implant itself and avoid the need to include additional drug carrier materials such as a polymers, which are often associated with inflammation and delayed healing/tissue regeneration at the implant site. One common feature of in vitro experiments to generate drug release profiles is stirring or agitation of the release medium. However, the influence of the resulting fluid flow on the rate of drug release from DFIs has yet to be quantified. In this paper we consider two DFIs, which although similar in shape and size, employ different strategies to control the release of drug: a porous pin with pores on the order of μm and a pin drilled with orifices of the order of mm. We develop a multiphysics mathematical model of drug release from these DFIs, subject to fluid flow induced through stirring and show that fluid flow greatly influences the drug release profile for the orifice pin, but that the porous pin drug release profile is relatively insensitive to flow. We demonstrate that drug release from the porous pin may adequately be described through a simplified radial 1D dissolution-diffusion model, while a 3D dissolution-advection-diffusion model is required to describe drug release from the orifice pin. A sensitivity analysis reveals that that the balance of reaction-advection-diffusion in terms of key nondimensional numbers governs the overall drug release. Our findings potentially have important implications in terms of devising the most relevant experimental protocol for quantifying drug release from DFIs.
Racism and Older Black Americans’ Health: a Systematic Review
Authors: LaFave S. E. , Suen J. J. , Seau Q. , Bergman A. , Fisher M. C. , Thorpe R. J. , Szanton S. L.
Published: January 2022

We reviewed research that examines racism as an independent variable and one or more health outcomes as dependent variables in Black American adults aged 50 years and older in the USA. Of the 43 studies we reviewed, most measured perceived interpersonal racism, perceived institutional racism, or residential segregation. The only two measures of structural racism were birth and residence in a “Jim Crow state.” Fourteen studies found associations between racism and mental health outcomes, five with cardiovascular outcomes, seven with cognition, two with physical function, two with telomere length, and five with general health/other health outcomes. Ten studies found no significant associations in older Black adults. All but six of the studies were cross-sectional. Research to understand the extent of structural and multilevel racism as a social determinant of health and the impact on older adults specifically is needed. Improved measurement tools could help address this gap in science.
Modeling and Simulation of Pore Formation in a Bainitic Steel During Creep
Authors: Meixner Felix , Ahmadi Mohammad Reza , Sommitsch Christof
Published: January 2022

In the field of power engineering, where materials are subjected to high pressures at elevated temperatures for many decades, creep-resistant steels are put to work. Their service life is still, however, finite, as the many changes in their microstructure can merely be mitigated and not avoided. Creep cavitation is one of those changes and, in many cases, ultimately causes failure by rupture. In this work, a model is proposed to simulate the nucleation and growth of cavities during creep. This exclusively physics-based model uses modified forms of Classical Nucleation Theory and the Onsager Extremum Principle in a newly developed Kampmann–Wagner framework. The model is validated on P23 steel which underwent creep rupture experiments at 600 °C and stresses of 50, 70, 80, 90 and 100 MPa for creep times up to 46000 hours. The model predicts qualitatively the shape and prevalence of cavities at different sites in the microstructure, and quantitatively the number density, size of cavities and their phase fraction contributing to a reduction in density. Finally, we find good agreement between the simulation and the experimental results especially at low stresses and longer creep times.
TREX1 Deficiency Induces ER Stress-Mediated Neuronal Cell Death by Disrupting Ca2+ Homeostasis
Authors: Halder Debasish , Jeon Su-Jin , Yoon Ji-Yong , Lee Jeong-Ju , Jun Soo Young , Choi Min-Hyuk , Jeong Bohyeon , Sung Duk Hyun , Lee Da Yong , Kim Byoung Joon , Kim Nam-Soon
Published: January 2022

TREX1 is an exonuclease that degrades extranuclear DNA species in mammalian cells. Herein, we show a novel mechanism by which TREX1 interacts with the BiP/GRP78 and TREX1 deficiency triggers ER stress through the accumulation of single-stranded DNA and activates unfolded protein response (UPR) signaling via the disruption of the TREX1-BiP/GRP78 interaction. In TREX1 knockdown cells, the activation of ER stress signaling disrupted ER Ca2+ homeostasis via the ERO1α-IP3R1-CaMKII pathway, leading to neuronal cell death. Moreover, TREX1 knockdown dysregulated the Golgi-microtubule network through Golgi fragmentation and decreased Ac-α-tubulin levels, contributing to neuronal injury. These alterations were also observed in neuronal cells harboring a TREX1 mutation (V91M) that has been identified in hereditary spastic paraplegia (HSP) patients in Korea. Notably, this mutation leads to defects in the TREX1-BiP/GRP78 interaction and mislocalization of TREX1 from the ER and possible disruption of the Golgi-microtubule network. In summary, the current study reveals TREX1 as a novel regulator of the BiP/GRP78 interaction and shows that TREX1 deficiency promotes ER stress-mediated neuronal cell death, which indicates that TREX1 may hold promise as a therapeutic target for neurodegenerative diseases such as HSP.
Emergency online school learning during COVID-19 lockdown: A qualitative study of adolescents’ experiences in Italy
Authors: Tzankova Iana , Compare Christian , Marzana Daniela , Guarino Antonella , Di Napoli Immacolata , Rochira Alessia , Calandri Emanuela , Barbieri Irene , Procentese Fortuna , Gatti Flora , Marta Elena , Fedi Angela , Aresi Giovanni , Albanesi Cinzia
Published: January 2022

The COVID-19 pandemic caused abrupt and profound changes to teaching and learning. The present study seeks to understand adolescents’ experiences of the emergency adoption of online school learning (OSL) during the first national lockdown in Italy. Sixty-four students in their final two years of high school were interviewed and content analysis was performed. The findings describe students’ views of the changes related to OSL according to structural, individual and relational dimensions. Schools’ lack of organization, overwhelming demands, as well as experience of difficulties in concentration, stress and inhibited relationships with teachers and classmates were among the challenges evidenced in the transition. OSL, however, has also made it possible to experience a new flexibility and autonomy in the organization of learning. The study stresses the importance of fostering adaptation of teacher-student relationships and collaborative learning in order to improve schools’ preparedness for digital transitions in and out of emergencies.
Psychological Well-Being and Social Competence During Adolescence: Longitudinal Association Between the Two Phenomena
Authors: Gómez-López Mercedes , Viejo Carmen , Romera Eva M. , Ortega-Ruiz Rosario
Published: January 2022

Despite previous research on adolescence points to an association between social competence and well-being, limited knowledge is available. Most studies have documented a one-way pattern of influence, although reciprocity has also been suggested. However, they mainly use a cross-sectional design, do not focus on psychological well-being, and do not use integrative and multidimensional constructs. From a eudaimonic approach to well-being and situation-specific to social competence, this study aimed to: (1) explore the factorial structure of the dimensions assessed; (2) analyse the longitudinal relationship between psychological well being and social competence during adolescence; and (3) examine psychological well-being and social competence levels and their stability over time. The sample consisted of 662 adolescents aged between 14 and 16 years old (Time 1 Mage = 14.63; SD = 0.64; 51% girls). Structural equation analysis confirmed the existence of second-order factors, showing evidence of a positive and bidirectional relationship between psychological well-being and social competence. Results also revealed medium–high levels in both constructs, which remained stable over time. These findings highlight the importance of promoting both psychological well-being and social competence to achieve successful, healthy development.
The geometric reason for the non-existence of a MOL(6)
Authors: Betten Dieter
Published: January 2022

The problem of Euler concerning the 36 officers, (Euler, in Leonardi Euleri Opera Ser I 7:291–392, 1782), was first solved by Tarry (Comptes rendus Ass Franc Sci Nat 1 (1900) 2:170–203, 1901). Short proofs for the non-existence were given in Betten (Unterricht 36:449–453, 1983), Beth et al. (Design Theory, Bibl. Inst. Mannheim, Wien, Zürich, 1985), Stinson (J Comb Theory A 36:373–376, 1984). This problem is equivalent to the existence of a MOL(6), i. e., a pair of mutually orthogonal latin squares of order 6. Therefore in Betten (Mitt Math Ges Hamburg 39:59–76, 2019; Res Math 76:9, 2021; Algebra Geom 62:815–821, 2021) the structure of a (hypothetical) MOL(6) was studied. Now we combine the old proofs and the new studies and filter out a simple way for the proof of non-existence. The aim is not only to give still other short proofs, but to analyse the problem and reveal the geometric reason for the non-existence of a MOL(6)- and the non-solvability of Euler’s problem.
When It Strikes, Are We Ready? Lessons Identified at the 7th Planetary Defense Conference in Preparing for a Near-Earth Object Impact Scenario
Authors: Ravan Shirish , De Groeve Tom , Mani Lara , Bjorgo Einar , Moissl Richard , Roncero Jose Miguel , Rowan Katherine , Schuld David , Lewis Leviticus A. , Kofler Romana
Published: January 2022

Near-Earth object (NEO) impact is one of the examples of high impact and low probability (HILP) event, same as the Covid-19 pandemic the world faces since the beginning of 2020. The 7th Planetary Defense Conference held by the International Academy of Astronautics (IAA) in April 2021 included an exercise on a hypothetical NEO impact event, allowing the planetary defense community to discuss potential responses. Over the span of the 4-day conference this exercise connected disaster response and management professionals to participate in a series of panels, providing feedback and perspective on the unfolding crisis scenario. The hypothetical but realistic asteroid threat scenario illustrated how such a short-warning threat might evolve. The scenario utilized during the conference indicates a need to prepare now for what might come in the future, because even with advance notice, preparation time might be minimal. This scenario chose Europe for the impact, which may likely cope with such a disaster, through the Union Civil Protection Mechanism (UCPM) and other solidarity and support mechanisms within the European Union (EU), as well as with potential support from international partners. This short article raises concern about other areas in the world on how they may access NEO impact information and cope with such disasters. It also provides an idea on vast scale of such disaster vis-à-vis the current capacity of response systems to cope with a larger event in Europe or elsewhere. This scenario showed that planetary defense is a global endeavor. Constant engagement of the planetary defense and disaster response communities is essential in order to keep the world safe from potential disasters caused by NEO impacts.
Cochlear Implantation in Advanced Otosclerosis: Pitfalls and Successes
Authors: Claussen Alexander D. , Gantz Bruce J.
Published: January 2022

Purpose of Review

This review will highlight recent outcome-based evidence guiding decision making for cochlear implantation in advanced otosclerosis, related complications, and technical surgical considerations in otosclerosis and the obstructed cochlea.

Recent Findings

Cochlear implantation in advanced otosclerosis results in consistent, excellent auditory outcomes with improvement in both objective speech recognition scores and subjective quality of life measures. Facial nerve stimulation may occur at higher rates in otosclerosis cochlear implant recipients. Cochlear implantation in the setting of luminal obstruction in osteosclerotic patients may be managed with altered surgical technique to achieve successful auditory improvements. Pre-operative imaging with high resolution CT or MRI may help anticipate intraoperative challenges and post-operative complications in cochlear implantation.

Cochlear implantation is an established, successful treatment for profound hearing loss in advanced otosclerosis. Surgeon knowledge of outcomes, complications, and potential surgical challenges is important to appropriately counsel patients regarding auditory rehabilitation options in advanced otosclerosis.
Modulation of spin dynamics in Ni/Pb(Mg1/3Nb2/3)O3-PbTiO3 multiferroic heterostructure
Authors: Xu Hang , Wang Bo , Qi Ji , Liu Mei , Teng Fei , Hu Linglong , Zhang Yuan , Qu Chaoqun , Feng Ming
Published: January 2022

Motivated by the fast-developing spin dynamics in ferromagnetic/piezoelectric structures, this study attempts to manipulate magnons (spin-wave excitations) by the converse magnetoelectric (ME) coupling. Herein, electric field (E-field) tuning magnetism, especially the surface spin wave, is accomplished in Ni/0.7Pb(Mg1/3Nb2/3)O3-0.3PbTiO3 (PMN-PT) multiferroic heterostructures. The Kerr signal (directly proportional to magnetization) changes of Ni film are observed when direct current (DC) or alternative current (AC) voltage is applied to PMN-PT substrate, where the signal can be modulated breezily even without extra magnetic field (H-field) in AC-mode measurement. Deserved to be mentioned, a surface spin wave switch of “1” (i.e., “on”) and “0” (i.e., “off”) has been created at room temperature upon applying an E-field. In addition, the magnetic anisotropy of heterostructures has been investigated by E-field-induced ferromagnetic resonance (FMR) shift, and a large 490 Oe shift of FMR is determined at the angle of 45° between H-field and heterostructure plane.
The antioxidative potential of sea grapes (Caulerpa lentillifera, Chlorophyta) can be triggered by light to reach comparable values of pomegranate and other highly nutritious fruits
Authors: Sommer Jonas , Kunzmann Andreas , Stuthmann Lara E. , Springer Karin
Published: January 2022

The interest in edible sea grapes (Caulerpa lentillifera) is increasing due to their potentially beneficial effect on human health. This macroalga, already used for direct and indirect human consumption, is grown in aquacultures in Vietnam and The Philippines. Here, the edible fronds of sea grapes were examined for their antioxidant activity (AOA) at light intensities from 140 to 300 µmol photons m−2 s−1 and compared to commercially dehydrated C. lentillifera and the renowned highly antioxidative fruits Pomegranates (Punica granatum), Goji (Lycium barbarum and L. chinense) and Aronia (Aronia melanocarpa) berries, using an ABTS+-assay for all samples. AOA of fronds exposed to 300 µmol photons m−2 s−1 for 14 days increased by about 320% from the initial value of 72.2 ± 5.6 to 232.2 ± 34.2 Trolox Equivalents (TE) mmol 100 g−1 dry weight (DW) onto the level of Pomegranates (272.8 ± 23.0 TE mmol 100 g−1 DW). This application could be used as a post-cultivation treatment in sea grape cultures to increase the quality and nutritional value of the product.
Sind schwache Leistung und auffälliges Verhalten immer ein Risiko für gelingende Partizipation? Zur Rolle von Kontext und Klassenkohäsion
Authors: Schürer Sina , van Ophuysen Stefanie , Marticke Sophie
Published: January 2022

Partizipation – speziell hohe Akzeptanz/geringe Ablehnung – aller Kinder ist Ziel inklusiver Bildung. Schwache Schulleistungen und Verhaltensprobleme stellen dabei einen Risikofaktor dar, allerdings mit deutlichen Unterschieden zwischen Schulklassen. Inwiefern können diese Unterschiede durch Klassenkohäsion erklärt werden? Gibt es differenzielle Zusammenhänge je nach Partizipationssituation sowie Art des Unterstützungsbedarfs? Für Daten einer standardisierten Befragung von 995 Grundschulkindern aus 45 Klassen wurden hierarchische Regressionsmodelle angepasst. Verhaltensauffälligkeiten und Lernschwierigkeiten sind prädiktiv für geringe Akzeptanz, nur ersteres geht auch mit hoher Ablehnung einher. Kohäsion erhöht Partizipation insgesamt, reduziert jedoch nicht den Nachteil für lernschwache oder verhaltensauffällige Kinder.
Retroperitoneal Mass: Lymphoma as Differential Diagnosis to Retroperitoneal Fibrosis: Case Report
Authors: Nussberger Madalina , Kim Olaf Chan-Hi , Cogliatti Sergio , Müllhaupt Gautier , Neumann Thomas
Published: January 2022

The etiology of solid retroperitoneal mass may be autoimmune or neoplastic and should be investigated by imaging and histology. The spectrum of differential diagnoses includes retroperitoneal fibrosis and retroperitoneal tumors. As treatment for these entities differs substantially, early and accurate diagnosis is essential. We present a case of a 54-year-old woman admitted to our hospital with stroke-like symptoms. Suspecting vasculitis, magnetic resonance imaging of the head and abdomen was performed, which revealed circular enhancement of the internal carotid artery as well as retroperitoneal and periaortic masses. In light of the radiographic findings, an autoimmune process, such as retroperitoneal fibrosis, was hypothesized. Steroid treatment was initiated but did not lead to significant remission. Re-evaluation of the mass with fine-needle aspiration did not show malignant cells while diagnostic surgery and histological assessment revealed neoplastic lymphoproliferation. The final diagnosis was a non-Hodgkin B-cell lymphoma. Chemo- and immunotherapy were initiated. Follow-up abdominal computed tomography revealed significant remission of the retroperitoneal mass. Initially, the retroperitoneal mass was highly suspicious for RF. While imaging can be useful, obtaining histology should always be considered when there is an uncertain clinical presentation. Without histology, we would have missed a non-Hodgkin B-cell lymphoma in this case. Minimally invasive techniques such as fine-needle aspiration may be practical but can give false-negative results.
Gentamicin-Montmorillonite Intercalation Compounds as an Active Component of Hydroxypropylmethylcellulose Bionanocomposite Films with Antimicrobial Properties
Authors: Darder Margarita , He Jing , Charlet Laurent , Ruiz-Hitzky Eduardo , Aranda Pilar
Published: January 2022

The present study introduces an overview of gentamicin-clay mineral systems for applications in biomedicine and then focuses on the development of a series of gentamicin/clay hybrid materials to be used as the bioactive phase of hydroxypropylmethylcellulose (HPMC) to produce bionanocomposite membranes possessing antimicrobial activity of interest in wound-dressing applications. Gentamicin (Gt) was adsorbed from aqueous solutions into a montmorillonite (Cloisite®-Na+) to produce intercalation compounds with tunable content of the antibiotic. The hybrids were characterized by CHN chemical analysis, energy-dispersive X-ray analysis, X-ray diffraction, Fourier-transform infrared spectroscopy, and thermogravimetric analysis, confirming the intercalation of Gt by an ion-exchange mechanism. The release of Gt from the hybrids was tested in water and in buffer solution to check their stability. Hybrids with various amounts of Gt were incorporated into a HPMC matrix at various loadings and processed as films by the casting method. The resulting Gt-clay/HPMC bionanocomposites were characterized by means of field-emission scanning electron microscopy, and were also evaluated for their water-adsorption and mechanical properties to confirm their suitability for wound-dressing applications. The antimicrobial activity of the bionanocomposite films was tested in vitro toward various microorganisms (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium, Acinetobacter baumannii, and Klebsiella pneumonia), showing a complete bacterial reduction even in films with small Gt contents.
A real-time network-based approach for analysing best–worst data types
Authors: Münnich Ákos , Vargáné Karsai Emese , Nagy Jenő
Published: January 2022

Best–worst scaling is a widespread approach in market research used for collecting data on the needs and preferences of people. However, the current preparation of its design and the analysis of the data depends on complex statistical methods. One of the most commonly used models for estimating individual preference probabilities is the hierarchical Bayes model, which can only be applied after the data collection phase. This type of calculation needs more infrastructural background and a large sample to provide accurate estimations. Here, we introduce a new application that enables fast calculations and individual-level real-time estimations, which also has a great potential to ask additional questions depending on the respondent’s answers during live interviews. Our network-based approach (integrating the PageRank algorithm) works well for online surveys, and it supports our dynamic and adaptive, real-time evaluation (DART) of best–worst data types, and results in more relevant decision making in marketing.
Online casinos: advertising and avoidance among Generation Y consumers in Sweden
Authors: Henriksen Julia , Hornebrant Malin , Berndt Adele
Published: January 2022

Online casinos are one of Sweden’s largest gambling sectors. Increased advertising investment and advertising frequency have sought to attract Generation Y consumers to these casinos, yet it has been suggested that advertising can contribute to avoidance behaviours towards products and services, including online casinos and specific gambling brands. The various advertising aspects used in gambling advertising and their impact on behaviour have not been widely researched. Thus, the purpose of this study was to explore the use of creative strategies in casino advertising and how it contributes to the avoidance of online casinos, specifically among Swedish Generation Y consumers. As an exploratory study, qualitative methods were used. Initially, 13 casino advertisements were analysed to identify the strategies used in the advertisements. These were then presented to Generation Y consumers in three focus groups and six in-depth interviews. The analysis of the advertising shows the use of people and characters in presenting the casino brand. Male voice-overs were utilised in addition to music and other casino-related sounds. The advertising also used bright colours to attract attention. The impact of these advertisements is that the content, the auditory cues rather than just music, the emotional response, and the frequency of the advertising were found to contribute to the avoidance of casino brands. Furthermore, the ethics and general attitudes to the industry impact the decision to avoid these brands. The managerial implication of this research shows the impact of advertisements on the decision to avoid a brand, specifically a casino brand.
Neural network-based adaptive sliding mode control for underactuated dual overhead cranes suffering from matched and unmatched disturbances
Authors: Wen Tianci , Fang Yongchun , Lu Biao
Published: January 2022

To improve transportation capacity, dual overhead crane systems (DOCSs) are playing an increasingly important role in the transportation of large/heavy cargos and containers. Unfortunately, when trying to deal with the control problem, current methods fail to fully consider such factors as external disturbances, input dead zones, parameter uncertainties, and other unmodeled dynamics that DOCSs usually suffer from. As a result, dramatic degradation is caused in the control performance, which badly hinders the practical applications of DOCSs. Motivated by this fact, this paper designs a neural network-based adaptive sliding mode control (SMC) method for DOCS to solve the aforementioned issues, which achieves satisfactory control performance for both actuated and underactuated state variables, even in the presence of matched and mismatched disturbances. The asymptotic stability of the desired equilibrium point is proved with rigorous Lyapunov-based analysis. Finally, extensive hardware experimental results are collected to verify the efficiency and robustness of the proposed method.
Comparing participation in sports discussion and art therapy groups in ABI
Authors: Moorhouse Bronwyn E. A. , Mainprize Erica R. , Douglas Jacinta M. , Fisher Caroline A.
Published: January 2022

Background:

Social connection is often impacted by acquired brain injury (ABI), contributing to isolation and compromised mental health. Group therapy is thought useful in this context. For those experiencing cognitive communication challenges, finding alternative ways to engage is also valuable. Art therapy may offer pro-social support through shared activity, self-expression, organic subject matter and enduring visual prompts.

Method:

A multiple A-B-A single case experimental design compared participation in sports discussion and art therapy groups on a long-stay secure unit. Nine individuals with ABI and complex combinations of communication, cognitive and mental health needs were studied. It was hypothesised that for some individuals, participation would be greater in art therapy than sports discussion groups.

Results:

Results from six individuals with at least five measurement points per phase are reported. Tau statistics revealed significant interphase differences for three individuals. Significantly less participation was recorded for two individuals in art than sports discussion, however they still appeared invested in the art groups. The remaining participant, with the most severe communication difficulties, avoided all baseline sports discussion groups, but participated in almost all art groups, with significant increase between initial sports discussion and art phases.

Conclusion:

Further research is warranted regarding the potential art therapy offers for group engagement, particularly where complex challenges render traditional talking-style groups less appropriate. Furthermore, disparate and complex needs in severe ABI require diverse, well-designed groups offering different opportunities and responding to individual strengths and motivations. More research into such approaches may increase group participation in this challenging cohort.
Análisis cronológico de las ocupaciones humanas en la cuenca inferior del río Deseado, Patagonia Argentina
Authors: Ambrústolo Pablo
Published: January 2022

Uno de los temas centrales de discusión en la arqueología de Patagonia se enmarca tradicionalmente en torno a la profundidad temporal de las ocupaciones humanas y su relación con el estudio de las estrategias de movilidad de los grupos cazadores-recolectores que habitaron diferentes espacios. A partir de la calibración y la suma de probabilidades de una muestra actualizada de dataciones radiocarbónicas obtenidas para la cuenca inferior del río Deseado, se identifica una secuencia ocupacional discontinua que se desarrolla durante el Holoceno medio y tardío. La información paleoclimática a escala regional y el carácter exploratorio de las ocupaciones humanas sugieren que un hiato cronológico identificado hacia el final del Holoceno medio (4988-3978 cal aP) podría estar vinculado con estrategias de abandono y relocalización del área, en función de dar respuesta a condiciones de aridez que habrían configurado un ambiente con escasa disponibilidad hídrica. Durante el Holoceno tardío final (entre ca. 1500 y 300 cal aP), el registro de espacios costeros ampliamente habitados y la identificación de un marcado crecimiento de la densidad de probabilidad de la curva de distribución de dataciones sugieren una trayectoria hacia un aumento poblacional en el marco de estrategias de movilidad asociadas al litoral atlántico.
Equivariant stable sheaves and toric GIT
Authors: Clarke Andrew , Tipler Carl
Published: January 2022

For $(X,\,L)$ a polarized toric variety and $G\subset \mathrm {Aut}(X,\,L)$ a torus, denote by $Y$ the GIT quotient $X/\!\!/G$. We define a family of fully faithful functors from the category of torus equivariant reflexive sheaves on $Y$ to the category of torus equivariant reflexive sheaves on $X$. We show, under a genericity assumption on $G$, that slope stability is preserved by these functors if and only if the pair $((X,\,L),\,G)$ satisfies a combinatorial criterion. As an application, when $(X,\,L)$ is a polarized toric orbifold of dimension $n$, we relate stable equivariant reflexive sheaves on certain $(n-1)$-dimensional weighted projective spaces to stable equivariant reflexive sheaves on $(X,\,L)$.
Geography and ecology of invasive Pseudosuccinea columella (Gastropoda: Lymnaeidae) and implications in the transmission of Fasciola species (Digenea: Fasciolidae) – a review
Authors: Ngcamphalala P.I. , Malatji M.P. , Mukaratirwa S.
Published: January 2022

Pseudosuccinea columella is considered invasive and has become an important intermediate host of both Fasciola species in many regions of the world. This systematic review assessed the geographical distribution of P. columella, and its implications in the transmission of Fasciola hepatica and Fasciola gigantica, globally. A literature search was conducted on Google Scholar, JSTOR and PubMed databases using Boolean operators in combination with predetermined search terms for thematic analysis. Results show that P. columella has been documented in 22 countries from Europe (3), Africa (8), Oceania (2), North America (3) and South America (6). Furthermore, this snail species has shown to adapt to and inhabit a vast array of freshwater bodies including thermal lakes and ditches with acidic soils. Studies showed that P. columella transmits F. hepatica, with natural and experimental infections documented in sub-Saharan Africa, Europe, South America and North America. Experimental infection studies in Cuba showed the presence of P. columella populations resistant to F. hepatica infection. Furthermore, some populations of this invasive snail collected from F. hepatica endemic locations in Brazil, Venezuela, Australia, South Africa, Colombia and Argentina were found without Fasciola infection. As a result, the role played by this snail in the transmission of Fasciola spp. in these endemic areas is still uncertain. Therefore, further studies to detect natural infections are needed in regions/countries where the snail is deemed invasive to better understand the veterinary and public health importance of this snail species in Fasciola-endemic areas and determine the global dispersion of resistant populations of P. columella.
Morphological and molecular characterization of Prosthogonimus falconis n. sp. (Trematoda; Prosthogonimidae), found in a peregrine falcon (Falco peregrinus) (Aves: Falconidae) in the United Arab Emirates
Authors: Schuster R.K. , Gajic B. , Procter M. , Wibbelt G. , Ruibal B. Arca , Qablan M.
Published: January 2022

At a routine health check of a female peregrine falcon, 23 trematodes preliminary identified as Prosthogonimus sp. were removed from the bursa of Fabricius. Based on morphological and molecular examination, a new species, Prosthogonimus falconis, was described. The pear-shaped flukes were 4.3–6.9 mm long, with greatest width posterior to testes. Tegumental spines measuring between 17 and 21 μm long covered the whole body. Length and width ratio of oral to ventral suckers were 1:1.3. Extracaecal, multifollicular vitelline glands commenced prior to acetabulum and terminated posterior to testes. Eggs in the distal uterus measured 21 × 12 μm. Molecular analysis of internal transcribed spacer 2, cytochrome c oxidase subunit 1 and NADH dehydrogenase subunit 1 gene regions revealed that the new species described here is phylogenetically closest to Prosthogonimus cuneatus and Prosthogonimus pellucidus clusters.