bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of Squamous Cell Lung Cancers from Appalachian Kentucky
Authors: Liu Jinpeng , Murali Thilakam , Yu Tianxin , Liu Chunming , Sivakumaran Theru A. , Moseley Hunter N.B. , Zhulin Igor B. , Weiss Heidi L. , Durbin Eric B. , Ellingson Sally R. , Liu Jinze , Huang Bin , Hallahan Brent J. , Horbinski Craig M. , Hodges Kurt , Napier Dana L. , Bocklage Thèrése , Mueller Joseph , Vanderford Nathan L. , Fardo David W. , Wang Chi , Arnold Susanne M.
Published: October 2018

Background:

Lung cancer is the leading cause of cancer mortality in the United States (U.S.). Squamous cell carcinoma (SQCC) represents 22.6% of all lung cancers nationally, and 26.4% in Appalachian Kentucky (AppKY), where death from lung cancer is exceptionally high. The Cancer Genome Atlas (TCGA) characterized genetic alterations in lung SQCC, but this cohort did not focus on AppKY residents.

Methods:

Whole-exome sequencing was performed on tumor and normal DNA samples from 51 lung SQCC subjects from AppKY. Somatic genomic alterations were compared between the AppKY and TCGA SQCC cohorts.

Results:

From this AppKY cohort, we identified an average of 237 nonsilent mutations per patient and, in comparison with TCGA, we found that PCMTD1 (18%) and IDH1 (12%) were more commonly altered in AppKY versus TCGA. Using IDH1 as a starting point, we identified a mutually exclusive mutational pattern (IDH1, KDM6A, KDM4E, JMJD1C) involving functionally related genes. We also found actionable mutations (10%) and/or intermediate or high-tumor mutation burden (65%), indicating potential therapeutic targets in 65% of subjects.

Conclusions:

This study has identified an increased percentage of IDH1 and PCMTD1 mutations in SQCC arising in the AppKY residents versus TCGA, with population-specific implications for the personalized treatment of this disease.

Impact:

Our study is the first report to characterize genomic alterations in lung SQCC from AppKY. These findings suggest population differences in the genetics of lung SQCC between AppKY and U.S. populations, highlighting the importance of the relevant population when developing personalized treatment approaches for this disease.
Anti-Inflammatory Drug Use and Ovarian Cancer Risk by COX1/COX2 Expression and Infiltration of Tumor-Associated Macrophages
Authors: Barnard Mollie E. , Hecht Jonathan L. , Rice Megan S. , Gupta Mamta , Harris Holly R. , Eliassen A. Heather , Rosner Bernard A. , Terry Kathryn L. , Tworoger Shelley S.
Published: October 2018

Background:

Nonsteroidal anti-inflammatory drug (NSAID) use may affect ovarian cancer risk via prostaglandin synthesis and tumor-associated macrophage (TAM) infiltration. We evaluated if associations between aspirin or non-aspirin NSAID use and ovarian cancer risk differed by tumor expression of prostaglandin-related (COX1, COX2) and TAM-related (CD68, CD163) markers.

Methods:

We evaluated cases and matched controls from the Nurses’ Health Study (NHS), NHSII, and New England Case-Control Study (NECC). Cases with IHC data on COX1 and COX2 (n = 532) or CD68 and CD163 (n = 530) were included. We used polytomous logistic regression, adjusted for ovarian cancer risk factors, to estimate OR for NSAID use and ovarian cancer risk by marker level.

Results:

Recent aspirin use had a nonsignificant inverse association and recent non-aspirin NSAID use had no association with ovarian cancer risk. NSAID use was not differentially associated with ovarian cancer by COX1 or COX2 expression. However, recent aspirin use was associated with lower ovarian cancer risk for high [OR 0.54; 95% confidence interval (CI), 0.37–0.78], but not low (OR 1.50; 95% CI, 0.97–2.31), CD163 density (Pheterogeneity < 0.001). Similar results were observed for aspirin duration and tablets and for recent non-aspirin NSAID use. Results were not clearly different by macrophage density defined by the less specific macrophage marker, CD68.

Conclusions:

NSAID use was inversely associated with risk of ovarian cancer with high density CD163, a marker for M2-type, immunosuppressive macrophages. However, the relationship did not differ by prostaglandin synthesis markers.

Impact:

Future research should explore prostaglandin-independent mechanisms for the association between NSAID use and ovarian cancer risk, including immune mechanisms.
Circulating Plasma miRNAs as Potential Biomarkers of Non–Small Cell Lung Cancer Obtained by High-Throughput Real-Time PCR Profiling
Authors: Niu Yanqin , Su Mingyang , Wu Yike , Fu Liwu , Kang Kang , Li Qing , Li Li , Hui Gang , Li Furong , Gou Deming
Published: October 2018

Background:

Because of limited stability and sensitivity, circulating miRNAs as noninvasive biomarkers have not so far been used for early diagnosis and prognosis of non–small cell lung cancer (NSCLC) in clinic. Therefore, it is imperative to find more reliable biomarker(s).

Methods:

We performed one of most sensitive qRT-PCR assays, S-Poly(T) Plus, to select differently expressed miRNAs from genome-wide miRNA profiling. miRNA candidates were validated through a three-phase selection and two validation processes with 437 NSCLC cases and 415 controls.

Results:

A unique set of 7 and 9 miRNAs differed significantly in adenocarcinoma (ADC) and squamous cell carcinoma (SCC) samples compared with those in controls, of which, there were 5 universal biomarkers for NSCLC (ADC or SCC). Ten of 11 miRNAs could discriminate early stage (stage I) of NSCLC from healthy individuals. Risk score was obtained from the validation set-1 and was tested using the ROC curves with a high area under ROC curve of 0.89 in ADC and 0.96 in SCC. Ultimately, potential biomarkers and the risk score were verified by the validation set-2 with a sensitivity of 94% and a specificity of 91.6% in ADC, and a sensitivity of 98.5% and a specificity of 51.5% in SCC, respectively.

Conclusions:

Taken together, 7 miRNAs and 9 miRNAs may provide noninvasive biomarkers for diagnosis and prognosis in ADC and SCC, respectively.

Impact:

On the basis of our sensitive and accurate method, we hope that these candidate miRNAs may have strong impact on the early lung cancer diagnosis.
Right Time and Place for IL12: Targeted Delivery Stimulates Immune Therapy
Authors: Lyerly H. Kim , Osada Takuya , Hartman Zachary C.
Published: October 2018

Systemic IL12 therapy has potent antitumor effects, but clinical delivery of this potent cytokine has been complicated by systemic toxicity. A novel strategy to deliver IL12 to the tumor microenvironment appears promising in a first-in-human study, appearing to stimulate tumor-specific adaptive immune responses with minimal systemic toxicity.

See related article by Strauss et al., p. 99
Chromatin Diminution in Cyclops kolensis Lill. (Copepoda, Crustacea) as a Radical Way to Inactivate Redundant Genome in Somatic Cells
Authors: Grishanin Andrey K. , Zagoskin Maxim V.
Published: October 2018

Chromatin diminution (CD) is a phenomenon of programmed DNA elimination which takes place in early embryogenesis in some eukaryotes. The mechanism and biological role of CD remain largely unknown. During CD in the freshwater copepod Cyclops kolensis, the genome of cells of the somatic lineage is reorganized and reduced in size by more than 90% without affecting the genome of germline cells. Although the diploid chromosome number is unchanged, chromosome size is dramatically reduced by CD. The eliminated DNA consists primarily of repetitive sequences and localizes within granules during the elimination process. In this review, we provide an overview of CD in C. kolensis including both cytological and molecular studies.
Elaboração mensural e motivicidade no Agnus Deida Missa L’homme Armé Super Voces Musicalesde Josquin Desprez
Authors: Iafelice Carlos C.
Published: October 2018

Este trabalho consiste na análise das elaborações mensurais e aspectos da periodicidade motívica presentes no Agnus Dei da Missa L’homme Armé Super Voces Musicales de Josquin Desprez. A análise é fundamentada a partir dos apontamentos sobre cânones mensurais realizados por Glareanus (Dodechocordon, 1547), Bellermann (Mensuralnoten und Taktzeichen des XV. und XVI. Jahrhunderts, 1906), Apel (The Notation of Polyphonic Music 900-1600, 1949) e por meio dos conceitos da ‘Motivicidade’ de Joshua Rifkin e ‘Agrupamentos Sonoros Plenos’ de Marcos Pupo Nogueira, elucidando características das estratégias composicionais utilizadas pelo compositor.
Solmização: regras para a nomeação das notas de acordo com autores ingleses no século XVII
Authors: Domingos Nathália
Published: October 2018

Este artigo tem como objetivo evidenciar as regras propostas pelos autores ingleses para a correta nomeação das notas durante a solmização por meio de três tratados seiscentistas representativos: A new way of making fowre parts (c. 1613) de Thomas Campion; An Introduction to the skill of musick in two books (1655) de John Playford e A compendium of practical musick (1667) de Christopher Simpson.
Pronuntiatio na obra de Silvestro Ganassi (1492-c.1557)
Authors: Tettamanti Giulia Da Rocha
Published: October 2018

Este artigo tem como objetivo apontar na obra de Silvestro Ganassi a presença de conceitos da oratória clássica amplamente cultivados no ambiente veneziano entre as décadas de 1530 e 1540. A influência destes elementos na obra do autor se nota pelo alto grau de sofisticação dos conteúdos e pela constante comparação entre as duas artes, principalmente no que diz respeito às partes do discurso que tratam da pronúncia que, neste caso, está diretamente relacionada à execução musical. Levando em consideração o ambiente político veneziano e as ideias humanistas que circulavam dentro das academias literárias desta cidade no século XVI, pretende-se fazer um recorte das diversas passagens na obra de Ganassi que fazem referência direta ou indireta à arte da oratória, para que, ao relacioná-las com as suas respectivas fontes, possamos ter uma maior compreensão do significado que a execução musical adquiriu neste ambiente.
Uma suíte, sua entabulação e a poética do alaúde barroco: considerações sobre a Suite em Sol Menor BWV 995 de Johann Sebastian Bach
Authors: Cardoso Renato De Carvalho
Published: October 2018

Este trabalho trata da contraposição entre a Suite em Sol menor para alaúde barroco, BWV 995, de Johann Sebastian Bach, com o manuscrito de época feito por um entabulador anônimo, conforme documentada no chamado Manuscrito de Leipzig (Coleção Becker III. 11. 3). Parte-se da ideia de que há um desalinhamento entre a obra concebida pelo compositor e a tradição instrumental na qual ela seria executada. Através de um procedimento comparativo de fontes, essa diferença será analisada em três tópicos: alteração do texto para fins de exequibilidade ao alaúde (supressão de notas, transposição de oitava, deslocamento rítmico); ornamentação (uníssonos alaudísticos, adição substanciosa de ornamentos, ornamentação do sujeito na fuga); articulação (ligados técnicos, de textura e fraseológicos, overlegato, articulação assimétrica). Dada a qualidade da adaptação à tablatura, é de conjectura entre musicólogos que o autor dessa entabulação seja um alaudista de alto nível profissional, do calibre de compositores como Silvius Leopold Weiss (1687 – 1750) ou Adam Falkenhagen (1697 – 1761), o que faz dessa fonte documental um marco qualitativo da prática interpretativa do barroco tardio. A reflexão empreendida busca valorizar a poética interpretativa da tradição alaudística no barroco, considerando sua particularidade criativa de se conceber a prática musical. Argumenta-se que fontes primárias como esta sejam de grande relevância para se entender mais de uma tradição instrumental, fruto da vida social dos músicos da época, e que elas devem ter um status privilegiado na abordagem da performance historicamente orientada.
Rediscutindo a relação entre música e linguagem a partir das análises de Paolo Virno
Authors: Barbeitas Flávio Terrigno
Published: October 2018

O texto analisa como algumas das novas concepções do fenômeno da linguagem, particularmente as do filósofo italiano Paolo Virno, podem alterar a maneira como ela é comparada com a música. Em vez de repropor um entendimento da linguagem nos moldes da tradição logocêntrica, ou seja, com o foco prioritariamente dirigido para o significado, o conteúdo e, portanto, o aspecto cognitivo, Paolo Virno aborda o sentido da linguagem como praxis, ressaltando seu aspecto performático e ritualístico.
‘Acervo João Mohana’ do Arquivo Público do Estado do Maranhão (APEM)
Authors: Cerqueira Daniel Lemos
Published: October 2018

Este breve artigo apresenta algumas considerações sobre a pesquisa no ‘Acervo João Mohana’ do Arquivo Público do Estado do Maranhão, visando a auxiliar o trabalho de musicólogos, intérpretes e demais pesquisadores interessados em estuda-lo. Há uma revisão de literatura sobre trabalhos ligados a este “acervo”, sucedida de informações sobre seu contexto histórico e descrições sobre problemas recorrentes na pesquisa. Questões de prática editorial são discutidas em um trecho de ‘Rêve d’Amour’, do compositor maranhense Ignácio Cunha (1871-1955), com indicação de aprofundamento com base em Grier (1996) e Figueiredo (2017). Conclusões apontam para democratizar o acesso a trabalhos semelhantes e aproximar as subáreas de Musicologia e Performance Musical/Práticas Interpretativas.
A textura musical na delineação formal de Dérives 1 de Pierre Boulez
Authors: Santos Jorge Luiz de Lima
Published: October 2018

O presente artigo busca demonstrar como a textura musical na obra Dérives 1 de Pierre Boulez é elemento central na delineação da forma e no direcionamento geral da obra. Forma entendida não apenas como o seccionamento temporal, mas como as relações internas entre os eventos sonoros. Utilizamos para extração de dados e análise duas teorias completares sobre a textura. A primeira, a teoria textural de Berry (1987) e, a segunda, a Análise Particional (GENTIL-NUNES, 2004). Sobretudo essa última, permite uma análise quantitativamente precisa dos eventos sonoros e uma visão global da textura na obra. Concluímos que a textura desempenha uma espécie de função cadencial, cumprindo o papel estruturante equivalente ao desempenhado pela harmonia no sistema tonal.
A ANÁLISE SINCRÔNICA E SUA RELAÇÃO MÚSICO-ESTRUTURAL
Authors: Iafelice Carlos
Published: October 2018

O moteto à cinco vozes, Jerusalem surge (‘Liber octavus ecclasiasticarum’, Tylman Susato, Antuérpia, 1553) de Jacobus Clemens non Papa, baseia-se no verso e no responsório de uma das antífonas cantadas no segundo domingo do advento. Neste estudo, propõe-se a análise considerando duas abordagens complementares entre si: (1) a leitura exegética pela análise sincrônica e (2) a análise das estruturas musicais reveladas a partir de fontes primárias alemãs. Um exame detalhado das possíveis relações entre tais aspectos contribui à uma abordagem que contemple a música como um meio pelo qual o texto evoca um modo particular de significação.
REPRESENTAÇÕES DO CAOS NA MÚSICA DO SÉCULO XVIII
Authors: Galhardi Felipe
Published: October 2018

O Caos tem sido tema de debate constante desde a Antiguidade, embora sejam poucos os estudos que abordem as representações do Caos na música. Obras musicais que imitem o Caos tampouco aparecem em grande quantidade na literatura musical. Contudo, o século XVIII testemunha pelo menos três importantes obras que se propõem a esta tarefa: a abertura Les Elemens (1737), de Jean-Féry Rebel, a abertura da ópera Zaïs (1748), de Jean-Phillippe Rameau e o prelúdio de A Criação (1798) de Joseph Haydn. Ao contrapor as obras, fica claro que, apesar das diferenças estilísticas, elas revelam muitos elementos em comum, tanto no que diz respeito ao uso da matriz clássica, que serve como ponto de partida para todas estas obras, quanto no que se refere às técnicas usadas para exprimir o Caos. Nesse artigo estudaremos as principais compreensões greco-latinas, seiscentistas e setecentistas acerca do Caos, trilhando o percurso desses pensamentos até os nossos compositores buscando encontrar uma unidade na maneira de se representar o Caos na música do século XVIII.
OS CONCEITOS DE GRAVITÀ E PIACEVOLEZZA DE PIETRO BEMBO
Authors: Freitas Ludmilla Thompson Sathler
Published: October 2018

Pietro Bembo, poeta e literato nascido em Veneza, publica em 1525 sua principal obra Prose della volgar lingua, um compêndio sobre o vulgar que estava sendo estabelecido como padrão literário italiano. É neste contexto de questione della lingua que nasce o madrigal italiano, um gênero de composição polifônica que destacou-se pela utilização de poemas de alta qualidade literária como os de Petrarca, defendido por Bembo. Uma análise “bembística” do texto pode dar diretrizes para a interpretação musical, tendo em vista que a música era composta a partir da palavra. Desta maneira pretende-se observar o poema O invidia sob a ótica das Prose e das categorias de gravità e piacevolezza nela propostos. Este poema foi musicado por Adrian Willaert, um dos expoentes do madrigal e contemporâneo de Bembo.
When a Short‐Term Outlook Is the Best Long‐Term Strategy: Time‐Varying Risk of Readmission After Acute Myocardial Infarction
Authors: Levy Andrew E. , Allen Larry A.
Published: October 2018

See Article by
Khot et al
‘Tot eeuwige memorie de druckerye-konste’
Authors: Dijkstra Trude
Published: October 2018

This article explores the ways in which early modern writers and readers related to and reflected on the Chinese invention of print by way of an examination of Simon de Vries’s Curieuse aenmerckingen der bysonderste Oost en West-Indische dingen of 1682. It will consider De Vries in his ternary role of author, compiler and reader, meaning that his account not only displays the economic rules of cultural consumption to which De Vries was bound as author and compiler, but also his own opinions and preferences as reader.

In the guise of writer, editor, and reader De Vries aims to present his potential readership with a thought-out consideration of the wide variety of European sources available on the subject of Chinese print, concentrating on those elements of contention that may speak for or against either Europe or China’s reputation as technological and cultural power. In the end, neither takes pride of place. By arguing for an independent invention of print, De Vries essentially put China on the same level as Europe.
Adapting Dynamically to Change in Diplomacy: A Comparative Look at Special Envoys in the International Arena
Authors: Morini Francesco
Published: October 2018

This article provides a comparative overview of the main features of special envoys/representatives dispatched by major foreign-policy players. It underlines the relevance of this instrument within a fast-changing diplomatic environment, characterized by increasingly numerous actors, evolving practices and complex processes that require a flexible approach. The analysis draws on nearly 650 cases of special envoys appointed by national administrations and international organizations over the span of 25 years, exposing commonalities and differences in the use of a long-standing diplomatic tool. The article argues that the incremental employment of ad-hoc envoys, mandated to deal with issues of a geographical or thematic nature, signals the ambition of individual actors to achieve specific policy objectives on a crowded global stage. In this perspective, and in keeping with their role of precursors in diplomatic practice, special envoys constitute a versatile resource with boundless potential in terms of adaptation to an ever-expanding diplomatic agenda.
The Reconstruction of the Circulation of Muḥammad al-Hindī’s Ǧumal al-falsafa Using Manuscript Notes
Authors: Jabbour Jawdath
Published: October 2018

Muḥammad al-Hindī’s Ǧumal al-falsafa is a philosophical summa from the 12th century CE. The text is preserved in two manuscripts: an autograph (Esad Efendi 1918) and a copy thereof. Various notes and annotations pervade MS Esad Efendi 1918’s fly-leaves and title-page. An examination of these, to date, understudied elements provides us with the only information that links this author to Yemen. It also reveals the steps taken on its journey, from 12th-century Yemen to Mamluk Egypt and Syria, and eventually Safavid Iran and Ottoman Istanbul.
Scattered Manuscripts
Authors: Khabibullaev Akram
Published: October 2018

This article examines notes left by readers, endowers, owners, or borrowers of manuscripts on their fly-leaves, title pages, colophons, etc. The notes under review were found on pages of different manuscripts belonging to the medieval library associated with the name of shaykh Khwājah Muḥammad Pārsā (d. 822/1420). The findings add to our knowledge of the intellectual history of medieval Bukhārā. They also shed some light on the history of Muḥammad Pārsā’s library and its physical location.
The Lives and Afterlives of the Library of the Maronite Physician Ḥannā al-Ṭabīb (c. 1702–1775) from Aleppo
Authors: Krimsti Feras
Published: October 2018

In eighteenth-century Aleppo, books acquired an unprecedented significance among Aleppo’s Christians, against the background of an expanding “culture of the book”. This paper attempts to reconstruct the library of the Maronite physician Ḥannā al-Ṭabīb (c. 1702–1775), based on ownership statements in manuscripts purchased by the German scholar and Oriental traveller Ulrich Jasper Seetzen (1767–1811) in Aleppo, presently preserved in Gotha’s Research Library. Proceeding from an assessment of the ownership statements and a thematic analysis of the library, the paper will address the implications for our understanding of book ownership in the social and intellectual milieu of the owner. It will be argued that owning books was a facet of an intensifying and active—not passive—preoccupation with literature among Christians.
Ibadis on (and in) the Margins
Authors: Love Paul M.
Published: October 2018

From at least the 17th century onward, a sizeable Maghribi Ibadi community lived, studied, and worked in the city of Cairo, centered around a trade agency, school, and library known as the ‘Buffalo Agency’ (Wikālat al-Jāmūs). Over nearly four centuries, this agency served as a hub for Ibadi intellectual activity and manuscript production. Despite its place of prominence in the history of early-modern Ibadi communities, manuscripts are some of the only surviving evidence of its existence. Using manuscript notes from and catalog data on manuscripts either held at the agency’s library or copied there, this article suggests that Ibadis were far from the small, isolated minority community in northern Africa they are often imagined to have been. Instead, the story of the Buffalo Agency points to the ways in which Ibadis very much belonged to the intellectual and commercial worlds of Sunni-dominated Cairo from the 17th–20th centuries.
Changing of the Guards: Politico-Religious Authority and Islamic Education in Mogadishu, Somalia
Authors: Ibrahim Ahmed Sh.
Published: October 2018

This article analyzes the impact of “modern”
1
education on Shari’a practice and authority in Mogadishu, Somalia. More specifically, the article looks at the influence of graduates from modern Islamic universities on the Shari’a court movement in Mogadishu. The Shari’a Courts of Mogadishu, as they are now known, began to emerge in the Somali capital after the disintegration of the previous regime in early 1991. The Courts were formed in various neighborhoods in the city at different times throughout the 1990s and early 2000s. They were organized and run by neighborhood religious authorities and traditional elders. The Courts were thus independent of each other. When the Courts began to unify starting in 2003, a new group of elites educated in modern Islamic universities played an important role in their unification. This article looks at the education and socialization of these elites and how their rise to power changed Shari’a practice and authority.
“Caring for the People”: ZuriaFM – An Islamic Radio Station in Asante, Ghana
Authors: Pontzen Benedikt
Published: October 2018

As an Islamic radio station, ZuriaFM stands as an exception in the heavily pentecostalized Ghanaian mediascape. In this essay, I locate this station in this mediascape and discuss the “Islamic sphere” it co-brings into being. Thereby, I complement the mainly Christian case studies of media, institutions, and actors in the Ghanaian public sphere with an Islamic one. ZuriaFM has emerged as a central platform for Muslims in the country, and has significantly (re-)shaped this “Islamic sphere” by introducing new styles of preaching, preacher figures, and opening topics for debate. In this sense, I by and large agree with the prevailing “transformation thesis” in the literature on “modern” media and “Islamic spheres” which stresses the fragmentation and liberalization of debates and authority. However, ZuriaFM could also be perceived as contributing to a unification of Islamic standards, which calls into question the one-sided stressing of fragmentation and liberalization of the “transformation thesis”.
Editorial Introduction: Architectural Projections of a ‘New Order’ in Fascist and Para-Fascist Interwar Dictatorships
Authors: Griffin Roger , de Carvalho Rita Almeida
Published: October 2018

The three articles that follow are the second part of a special issue of Fascism devoted to case studies in ‘Latin’ architecture in the fascist era, the first part of which was published in volume 7 (2018), no. 1. The architecture of three clearly para-fascist regimes comes under the spotlight: those of Spain, Portugal, and Brazil, in each of which a genuine fascist movement was either absorbed into a right-wing dictatorship (as occurred under Franco) or disbanded by it while perceptibly retaining some fascist elements (as in the case of the Salazar and Vargas regimes). Once again, the juxtaposition of the articles reveals unexpected elements of internationalism, entanglements, and histoires croisées both sides of the Atlantic in the impact of the fascist experiments in Germany and Italy.
Where Does Niklas Luhmann’s Card Index Come From?
Authors: Cevolini Alberto
Published: October 2018

Thanks to a grant of the Nordrhein-Westfälische Akademie der Wissenschaften und der Künste, Bielefeld University has started a fifteen-year project (2015–2030) that includes the production of a critical edition of Niklas Luhmann’s extant works and manuscripts, as well as the digitalization of his famous card index. This valuable enterprise has rekindled interest in what many scholars hold to be a ‘holy grail’: a marvelous instrument that aided great creativity and scientific production by the German sociologist. Indeed, people feel that looking inside the filing cabinet is like looking inside the mind of a genius at work. This article suggests a different point of view, rooted in the Enlightenment project of the sociologist of Bielefeld. The main hypothesis is that in the use of a card index as a surprise generator, there is nothing particularly surprising if one considers the evolution of knowledge management in early modern Europe. Rather, the question should be: how it is possible to explain the evolutionary improbability of the social use of ‘machines’ as secondary memories for knowledge management and reproduction? This article provides some suggestions for research and tries to determine where Luhmann’s card index comes from.
Quercus pseudosetulosa, a new species of Quercus sect. Ilex (Fagaceae) from Dawanshan Island, Guangdong, China
Authors: LI QIANSHENG , LI SHENGCHUN , LIN DUOQING , SHAO WEN , TU TIEYAO
Published: October 2018

A new species of Quercus (Fagaceae), Q. pseudosetulosa is described and illustrated from Dawanshan Island in Guangdong, China. The new species belongs to the Q. setulosa morpho-complex with glabrous leaf abaxial surface and acuminate tip, but it differs from other related species by its leaf with long petioles, large, thickly leathery, glabrous, the irregular spaced secondary veins, the inconspicuous tertiary veins and the recurved leaf blades. Its distribution, habitats and conservation status are also addressed.
A newly recognised species of Cryptes Maskell 1892 (Hemiptera: Coccidae) from Western Australia
Authors: LIN YEN-PO , KONDO TAKUMASA , KONDO TAKUMASA , GULLAN PENNY J. , COOK LYN G.
Published: October 2018

Cryptes utzoni Lin, Kondo & Cook sp. n. (Hemiptera: Coccidae) is described based on adult female morphology and DNA sequences from mitochondrial and nuclear loci. This Australian endemic species was found on the stem of Acacia aneura (Fabaceae) in Western Australia. All phylogenetic analyses of three independent DNA loci show that C. utzoni is closely related to C. baccatus (Maskell), the type and only species of Cryptes Maskell, 1892. The adult female of C. utzoni is described and illustrated and a table is provided of the characters that differ among adult females of the two species of Cryptes now recognised (C. baccatus and C. utzoni) and a morphologically similar Western Australian species, Austrolichtensia hakearum (Fuller). There is deep genetic divergence in COI among samples of C. baccatus, suggesting the possibility of a species complex in this taxon.
A new species of Limnonectes (Amphibia: Anura: Dicroglossidae) from Vietnam
Authors: PHAM CUONG THE , LE MINH DUC , NGO HANH THI , ZIEGLER THOMAS , NGUYEN TRUONG QUANG
Published: October 2018

A new species of Limnonectes from central Vietnam is described based on morphological and molecular differences. Morphologically, the new species is distinguishable from its congeners on the basis of a combination of the following diagnostic characters: SVL 47.5–60.9 in males, 42.3–51.1 mm in females; males with moderately enlarged head (HL/SVL 0.48), head longer than wide; vomerine teeth present; external vocal sacs absent; rostral length short (RL/SVL 0.14 in males, 0.15 in females); tympanum invisible; dorsal surface of head, body, and flanks smooth; dorsal surface of tibia and foot distinctly tuberculate, covered with moderately dense, small, low tubercles; supratympanic fold present; dorsolateral fold absent; toes webbed to posterior of terminal phalanx; in life, dorsum with light yellowish brown markings, throat and chest white with brown markings, and ventral surface of abdomen white or white with brown markings. In phylogenetic analyses, the new species is the sister taxon to an undescribed species from Cambodia.
Immature stages of Murgantia histrionica (Hemiptera: Pentatomidae)
Authors: BRITO LUCAS CAVALCANTI , SANTOS SUELLE MARIA DOS , BARÃO KIM RIBEIRO
Published: October 2018

Immature stages of Murgantia histrionica (Hemiptera: Pentatomidae) are described using light and scanning electron microscopy. Specimens of all life stages of M. histrionica were collected on Peritoma arborea (Cleomaceae) in Palm Springs, California. Specimens were observed in light and scanning microscopies, imagens taken and described based on specimens and photographs. We provide images of the eggs and immatures in light microscopy, and SEM of the eggs and first and fifth instars. Eggs of M. histrionica are barrel-shaped, white, with brown band and circular spot; the corium surface carinated, forming hexagonal cells; carinae irregular apically. The nymphal color pattern; the reflexed lateral margins of pro- and mesothorax; and the scattered punctuation of the tegument are a combination of characteristics enabling M. histrionica identification in its nymphal stages. The eggs of M. histrionica are similar in shape, color, and size to other Strachiini genera, such as Bagrada, Eurydema and Stenozygum. Among the Strachiini, the correct identification of M. histrionica based on immatures is possible by the shape of the head and pronotum, overall size of immatures, and coloration patterns.
The Ratio of Fibrinogen to Albumin as a Predictor of Contrast-Induced Nephropathy After Carotid Angiography
Authors: Ertas Faruk , Avci Eyup , Kiris Tuncay
Published: October 2018

Contrast-induced nephropathy (CIN) is acute kidney failure that occurs after exposure to contrast agent. There is no sensitive biomarker to predict the development of CIN. In a retrospective study, we investigated the predictive value of the fibrinogen to albumin ratio (FAR) to determine the risk of CIN in patients (N = 246) who underwent carotid angiography. Contrast-induced nephropathy was defined as a 0.5 mg/dL or 25% increase in serum creatinine levels 48 to 72 hours following exposure to a radiocontrast agent. Patients were grouped according to whether they developed CIN or not, that is, CIN(–) and CIN(+) groups, respectively. Contrast-induced nephropathy developed in 39 (15.8%) of all the patients. The fibrinogen levels, neutrophil to lymphocyte ratio (NLR), and FAR in the CIN (+) group were higher than in the CIN (−) group ( P < .001). Multivariate analysis showed that age, diabetes, NLR, platelet–lymphocyte ratio, and FAR were independent risk factors for CIN. The area under the curve (AUC) of FAR was 0.800 for the prediction of CIN, and the best cutoff value was 57.4 with sensitivity, specificity, positive predictive value, and negative predictive value of 74.4%, 60.8%, 26.4%, and 92.7%, respectively. The FAR may be useful as a predictor of CIN.
Direct and indirect psychological impacts of shark-bite events
Authors: Taylor Jennifer , McLean Loyola , Korner Anthony , Glozier Nicholas
Published: October 2018

Objective:

Shark bites are rare, with intense media exposure. There are no known studies of the psychological impacts of this specific type of traumatic event. This is the first study that describes those directly and indirectly affected, and evaluates the prevalence of post-traumatic stress disorder (PTSD) and related risk factors.

Methods:

In total, 124 members of an Australian shark-bite peer-support group were invited to complete an online survey assessing demographic, event, media and psychological factors. Response rate was 48% ( n = 60, 63% male, 44 ± 14 years). Retrospective and current measures of PTSD (PTSD Checklist for DSM-5 [PCL-5]) and suicidality (Suicidal Ideation Attributes Scale [SIDAS-5]) were used.

Results:

Post-event PTSD was prevalent in this sample ( n = 16/59, 27.1%, 95% confidence interval [CI] = [15.4, 38.8]), but less so currently ( n = 2/55, 3.6%, 95% CI = [0.0, 8.7]). In addition, nine ( n = 9/59, 15.3%, 95% CI = [5.8, 24.7]) had subthreshold, but highly symptomatic, syndromes post event. There was no association of PTSD with direct/indirect bite involvement, gender, or prior trauma. Two respondents were at risk of suicidal behaviour. PTSD was commonly reported by those without a partner (odds ratio [OR] = 5.91, 95% CI = [1.52, 22.99], p = 0.01) or with two friends or fewer to rely on (OR = 5.83, 95% CI = [1.62, 21.01], p = 0.01). PTSD was more likely in those with a negative media experience ( n = 34/52, 65.4%, OR = 11.90, 95% CI = [1.42, 100.04], p = 0.02) and 61.5% ( n = 32/52) of respondents reported media coverage lasting months or years. In multivariate modelling, negative media impact, relationship status and friendships were independently associated with PTSD and explained much of the variance in PTSD ( F4,41 = 10.94, p < 0.0001, r2 = 0.52).

Conclusion:

Nearly one-third of members of an Australian shark-bite peer-support group report post-event PTSD, and one-quarter of these were not present at the time of the event. Findings support interventions targeting negative media impact, similar to media reporting guidelines for suicide, and enhancing social support.
Sins for some, virtues for others: Media coverage of investment banks’ misconduct and adherence to professional norms during the financial crisis
Authors: Roulet Thomas J
Published: October 2018

Why does professional misconduct persist in the face of media scrutiny? In this study, we explain how professional norms can be at odds with societal norms and how the behaviours they trigger can be perceived as misconduct. Most audiences tend to disapprove of wrongdoings, but specific stakeholders may interpret this disapproval as an indication of the focal organization’s level of adherence to professional norms. Building on mixed methods, we explore the case of the investment banking industry during the financial crisis and suggest that corporate customers were favourably biased by the reporting of banks’ misconduct in the print media as they linked it to the banks’ quality of service. We capture the extent to which banks are associated with misconduct, signalling their adherence to negatively perceived professional norms. We then look at how such signalling affects the likelihood for banks to be invited into initial public offerings syndicates. Our findings show that the more banks are disapproved of for their wrongdoings, the more likely they are to be selected to join a syndicate. This study suggests that the coverage of misconduct can actually act as a positive signal providing banks with incentives to engage in what is broadly perceived as professional misconduct.
Intraprostatic Endoprosthesis
Authors: De Luca V. , Frego E. , Giambroni L , Cozzoli A. , Simeone C. , Da Pozzo G.P. , Zambolin T. , Cosciani-Cunico S.
Published: October 2018

The indications and advantages of an intraprostatic endoprosthesis (IPEP) in the case of obstructive symptoms and urinary retention in patients with BPH are well known. The aim of this study is to report our preliminary experience in the use of a new IPEP which has been developed at our Institute. This prosthesis can be easily positioned, shows little invasiveness and does not require ultrasonic, radiological or endoscopic guidance. The IPEP consists of three detachable parts, which are assembled coaxially to form an ordinary catheter. This procedure is made easier by a knob on the catheter which can be localized by inserting a finger into the rectum. The unit is compact, flexible and smooth. While positioning the IPEP, it is also possible to insert it and draw it back without causing any change to its shape. It is positioned by following the same procedure used for catheters. From November 1989 to April 1991, IPEP prototypes were inserted, with patients’ permission, in 16 patients with BPH and a residual urine volume of 150 cc (mean age 67 years; range 52 to 83 years). In all cases the procedure lasted only a few minutes. In 11 patients the prosthesis was correctly positioned, their stop test and uroflowmetry being valid. In 2 (12%) the procedure was not immediately successful and an additional catheter had to be used. In 3 (19%), it was repositioned.
Hemodilution and Autotransfusion in Bph Surgery
Authors: Merlo F. , Anselmo G.
Published: October 2018

Blood loss during prostatic surgery is related to the size of the prostatic adenoma and the need to carry out transfusions varies from 6.5% in transurethral surgery (Mebust) to 65% in open surgery (Meyhoff), with all the risks involved in homologous transfusions (hepatitis A, B, non A-non B, cytomegalovirus, Epstein - Barr virus, HIV-Aids). Autotransfusion, apart from reducing such serious risks, has the undoubted advantage of hemodilution. It has been demonstrated that reduction of the hematocrit improves oxygen supply to the tissues. The programme of autodonation-hemodilution set up at the Urology Department in Treviso in 1985 has resulted in average pre-operative hemoglobin values of 12.6 g compared to 14.4 in pre-donation, with a pre-deposit per patient of 1–3 bags of concentrated erythrocytes. In 1990, 70% of patients operated received only autologous blood, while donor transfusions were given in 18 out of 298 operations (6%). This method is extremely advantageous for improving tissue perfusion, for saving blood and reducing transfusional and thromboembolic risks. It also provides economic-social savings and is always well accepted, and is indeed greatly requested today, by patients being operated.
Schwannoma of the Penile Shaft. Case Report
Authors: Watanabe T. , Oosaki N. , Kano K. , Tsutsui T. , Tanikawa T.
Published: October 2018

A case of Schwannoma arising from the penile shaft is reported. The patient ignored the tumor for about five years because he felt no pain. Cystourethrograms showed the tumor did not cause urethral compression. Histologically the tumor belonged to the Antoni A type category. Resection of the tumor, which included the tunica albuginea, did not cause bending of the penis during erection. The postoperative course was uneventful and he had no detectible recurrence as of July 1990.
10 Year Follow-Up in a Group of Patients with Rpc (Belluno-Feltre)
Authors: Drei G.N. , Cian E. , D'Incà G. , De Marchi G. , Faccioli F. , Camagna M.T. , Guazzieri S.
Published: October 2018

Several different parameters, both clinical and pathological are used to prognosticate renal parenchymal carcinoma (RPC). In the present report we have analyzed prognosis according to our experience, based upon the pathological staging of disease performed at the time of nephrectomy, early diagnosis, nuclear grading, the infiltration of blood vessels and metastases.
Surgical Resection of Lung Metastases in Renal Cell Carcinoma
Authors: Cozzoli A. , Milano S. , Cancarini G. , Zanotelli T. , Cunico S. Cosciani
Published: October 2018

The Authors report their experience with surgical treatment of lung metastases from renal cell carcinoma. From June 1986 to July 1991, 19 patients were submitted to contemporary or subsequent lung metastasectomy. Histological examination confirmed the presence of lung metastases due to renal cell carcinoma in 16 cases (6 synchronous and 10 metachronous with a mean disease-free interval of 23 months). In the other 3 cases, histological examination revealed tuberculomas, chondroid hamartoma and foci of anthracosis. To date, among the 6 patients with synchronous lung metastases, 3 have died, 2 are in progression and 1 is NED after a mean-time survival of 74 months. Among the 10 patients who underwent surgical resection of lung metachronous metastases, 1 has died, 3 are in progression and 6 are NED (mean-time survival of 43 months). In conclusion, while the presence of synchronous lung metastases is an unfavourable prognostic factor even after surgical removal (5 out of 6 patients died or are in progression shortly after metastasectomy), the results after surgery of metachronous lung metastases are encouraging, but the real efficacy of this treatment is still to be confirmed.
Continuous Circadian Infusion of Fudr Associated with Interferon in Metastatic Renal Cell Cancer Treatment
Authors: Bianco M. Dal , Guatelli S. , Galetti T. Prayer , Avogaro F. , Barusco G.
Published: October 2018

The prognosis of metastatic renal cell cancer (RCC) is poor due to the lack of an effective treatment. Continuous circadian infusion of FUDR (5-fluoro-deoxyuridine) by the implantable Synchromed-Medtronic infusion system achieves an effective response in 24% of cases. The association with interferon seems to increase response rate. The Authors report their preliminary experience in 5 patients with metastatic RCC treated with chronoinfusion of FUDR and interferon. All patients tolerated the treatment well and no major toxicity was observed.
The Role of Radiotherapy for Adult Renal Cell Carcinoma
Authors: Fior S. Dal , Bordin A. , Iannone T.
Published: October 2018

In this paper the most important articles about the role of radiotherapy for renal cell carcinoma (CPR) are reviewed. Both pre- and post-operative radiotherapy do not seem to improve the survival rates, nor perhaps the local control in comparison with surgery. But trials have been limited and with evident bias: patients were staged without stratification for prognostic factors (grading and lymphonode metastases in particular) and radiotherapy techniques were often incorrect because of too frequent early and late damage. The role of radiotherapy for treating the metastatic disease is undisputed Particularly for patients with a single metastasis, because of the possibility of long survival if adequately controlled.
Radical Cystectomy in Elderly Patients
Authors: Bassi P. , Alipour M. Gholam , Ferrante G.L. Drago , Piazza N. , Panza N. , Mangano A. , Trevisan M. , Paganini S. , Croce G. , Cassone E. , Garbeglio A.
Published: October 2018

Radical cystectomy is the most common treatment for deeply invasive bladder cancer; due to reported operative risks, concerns have been expressed regarding the suitability of this operation in elderly patients. We reviewed the morbility and mortality rates in 50 patients aged 70 years and over (elderly group), undergoing radical cystectomy and urinary diversion, to verify if this procedure could be considered as initial treatment in older-age patients. The findings were compared with those observed in 50 patients aged 40 to 69 years (control group). In the elderly group there was no operative mortality; however 2 patients (4%) died post-operatively due to pulmonary embolism and multi-organ-failure syndrome respectively. Four patients (8%) were re-operated due to intestinal obstruction (2 pts), pelvic hematoma (1 pt) and wound dehiscence (1 pt). Wound separation was the more frequent complication (15%); 6% of patients experienced extended intestinal atonia. The length of hospital stay was 17.1 days. In the control group, surgical complications were comparable to those observed in the elderly group: furthermore medical complications were more frequent. In conclusion, these data suggest that radical cystectomy and urinary diversion can be safely performed in the elderly. Radical surgery is an effective treatment modality for elderly individuals who are in reasonably good general health. A higher incidence of medical complications must be expected in elderly patients.
Infected Hydronephrosis of Pregnancy with Renal Abscess Formation: Role of the Percutaneous Nephrostomy
Authors: Singer D. , Guy M. , Eisenkraft S. , Maner M.
Published: October 2018

Hydronephrosis of pregnancy is a physiological phenomenon and usually asymptomatic. When it becomes associated with intractable or prolonged pain, infection refractory to antibiotics or extreme dilatation damaging the obstructed kidney, invasive intervention is necessary. Percutaneous nephrostomy is the procedure of choice for draining the acutely obstructed kidney early, rapidly and continuously. We present two cases of unusual severity, one of them being the first report of renal abscess formation complicating hydronephrosis of pregnancy. The role, advantages and some technical points of percutaneous nephrostomy are discussed.
Bladder Instability
Authors: Tallarigo C. , Schiavone D. , Pianon R. , Baldassarre R. , Giusti G. , Rovasio A.
Published: October 2018

Bladder instability is undoubtedly a major cause of incontinence. The condition is reasonably well-defined and advances in the last 20 years in the urodynamic diagnosis of the condition have stimulated a number of leading clinicians and research workers to focus their attention on this problem. The aim of this paper is to produce a better understanding of the unstable bladder.
Report On: “Flow Cytometry in Bladder Tumours”. Introduction
Authors: Franzolin N.
Published: October 2018

Since bladder tumours are showing an increasing incidence in the adult population, even in our region, and considering the radical therapy that they often require, the reason becomes clear why it is so important to understand as much as possible about the actual evolutive properties of every single tumour in every single patient. Endoscopic and morphologic features of a tumour are often insufficient to predict its biological behaviour, and it can often be successfully treated conservatively. Flow cytometry (FCM) gives a rapid and objective analysis of tumoral cell ploidy and proliferative activity. Many of the reports found in Literature indicate how FCM may give accurate interesting information concerning the biological characterisation and the clinical evolution of bladder tumours. For the XXXIII meeting of the Associazione Triveneta di Urologia, “Flow cytometry in bladder tumours” has been chosen as the main topic, because of the interesting role it might play in the knowledge of the biology of these tumours.
Dna Flow Cytometry in Bladder Tumours: New Perspectives
Authors: Giaretti W.
Published: October 2018

An International “DNA Cytometry Consensus Conference” was held in October 1992, in Maine (USA): The Author reports the opinions concerning bladder tumours, expressed by the experts at the Conference. Models for future studies with Flow Cytometry are also reported.