bluuebunny/crossref_metadata_2025 huggingface dataset:
Pathology Associated with Adherent Perirenal Fat and its Clinical Effect
Authors: Ceyhan Erman , Ileri Fatih , Aki Fazıl Tuncay , Yazici Mustafa Sertac , Karcaaltincaba Musturay , Baydar Dilek Ertoy , Bilen Cenk Yucel
Published: March 2021

Introduction The dissection of perirenal fat is of critical importance
to kidney surgery and ease of dissection is more important when using
minimally invasive approaches. This study aimed to determine the
clinical, radiological, and pathological significance of adherent
perirenal fat(APF). Materials and Methods This prospective study
included 22 patients scheduled for partial nephrectomy and 40 patients
for donor nephrectomy. Intra-operative fat dissection time was recorded
and the complexity of perirenal fat dissection was surgeon-classified as
easy, moderate, and difficult. Perirenal fat and subcutaneous fat
thickness was measured. Measurement of perirenal fat depth, and the
Hounsfield unit(HU) for both perirenal and subcutaneous fields was
performed using CT images. All specimens were submitted for
histopatological analysis. Researchers in each arm were blinded to other
researchers’ data. Results Mean age of the patients was 51.3±12.7years.
Mean perirenal fat dissection time was 15.0±13.5min. Patient
demographics, BMI, nor occupational status differed between the 3
complexity of perirenal fat dissection groups. Radiological findings
showed that there was a significant correlation between perirenal fat
depth and complexity of perirenal fat dissection(p<0.05), but
not with HU measurements or subcutaneous fat thickness. Surgeon
classification of the complexity of perirenal fat dissection was in
accordance with the duration of dissection(p<0.05).
Perinephric fat contained more fibrous tissue in the patients with
histologically proven APF than in those without(p<0.05).
Conclusions APF is a challenge during kidney surgery. Difficult
dissection prolongs the duration of surgery, which can lead to
complications. Perirenal fat thickness measured via pre-operative CT
might be used to predict APF.
Penerapan Metode Snowball Throwing untuk Meningkatkan Motivasi dan Hasil Belajar Siswa pada Pembelajaran Agama Hindu
Authors: Brata Tapa Dewa Gde
Published: March 2021

Penelitian ini dilaksanakan di SD Negeri 6 Gianyar di kelas VI yang kemampuan siswanya untuk mata pelajaran Agama Hindu masih sangat rendah. Tujuan penulisan penelitian tindakan kelas ini adalah untuk meningkatkan motivasi dan hasil belajar Agama Hindu siswa kelas VI di SD Negeri 6 Gianyar tahun pelajaran 2018/2019 melalui penerapan metode Snowball Throwing. Metode pengumpulan datanya adalah observasi dan tes hasil belajar. Metode analisis datanya adalah deskriptif. Dengan hasil yang diperoleh dari penelitian ini adalah model pembelajaran yang diterapkan dapat meningkatkan hasil belajar siswa. Ini terbukti dari hasil yang diperoleh pada awalnya hanya mencapai rata-rata 7,06 dan ketuntasan belajar 66,00%, pada siklus I meningkat menjadi 7,80 dengan ketuntasan belajar 87% dan pada Siklus II meningkat menjadi 8,87 dengan ketuntasan belajar mencapai 100%. Kesimpulan yang diperoleh dari penelitian ini adalah penerapan metode Snowball Throwing dapat meningkatkan motivasi dan hasil belajar Agama Hindu siswa kelas VI SD Negeri 6 Gianyar tahun pelajaran 2018/2019.
A commentary on the value of hospital data for covid-19 pandemic surveillance and planning
Authors: Manuel Douglas G. , Van Walraven Carl , Forster Alan J.
Published: March 2021

Hospital data for covid-19 surveillance, planning and modelling are challenging to find worldwide in public aggregation portals.
Detailed covid-19 hospital data provides insights into covid-19’s health burden including identifying which sociodemographic groups are at greatest risk of covid-19 morbidity and mortality. Timely hospital data is the best source of information for actionable forecasts and projection models of hospital capacity, including critical resources such as intensive care unit beds and ventilators that take time to plan or procure.
A challenge to generate timely and detailed hospital data is the reliance on separation or discharge abstracts and census counts. What are needed are well-maintained lists of patients hospitalized with covid-19.
From the standpoint of public health and health services researchers and practitioners, we describe the role of hospital data for studying covid-19, why admission data are hard to find, and how improved data infrastructure can meet surveillance and planning needs in the near future. Modern hospital electronic health records can create covid-19 patient lists and these decision support tools are increasingly used for research. These tools can generate patient lists that are transmitted and combined with public health data systems.
Economic Implications Before and After the Covid-19 Pandemic Progressing Towards a ‘New Normal’
Authors: Somani Parin
Published: March 2021

The aim of this study is to understand the economic implications before and during the COVID-19 pandemic to facilitate progression towards a ‘new normal’ society post-pandemic. There is a focus on the Indian economy. The COVID-19 pandemic has created a grave impact on the economy affecting employment systems, where many learned youths have lost their jobs. Education systems have been faced with closures of institutions and decreased funding. Financial Markets have been affected with a negative growth rate in GDP, external trade, the political system, Indian cooperate companies, the agricultural sector, the elderly people in society, women and migrate laborers who have endured the ‘black march’ walking from Southern India to Northern India have all be affected. During the pandemic there has been enormous disruption to society, many disparities have been highlighted and immense economic loss. There have been effects on economic developments, civilization, and human direction. It is paramount to learn from the past pandemics, forming a restructured and sustainable future that society can call ‘normal’. Hence the pandemic has provided an opportunity to create and employ new strategies to aid future economic development by preventing past mistakes. The increase in global digital economy will facilitate informed decisions to be made during COVID-19, and aid towards rebuilding the economy, promoting growth and prosperity in a safe way. It will also enable countries globally to together with resilience to create a ‘new normal’ society.
PENGARUH CURRENT RATIO, DEBT TO EQUITY RATIO, TOTAL ASSET TURNOVER DAN KEBIJAKAN MANAJERIAL TERHADAP PERTUMBUHAN LABA
Authors: Hanifah Nadia , Hendra Kartika , Nurlaela Siti
Published: March 2021

Earnings growth is an increase in profit or decline in profit per year and can be used to assess how the development of a company's performance. The purpose of this study is to examine and analyze the effect of current ratio, debt to equity ratio, total asset turnover and managerial ownership on earnings growth. The population in this study is the banking sub-sector companies listed on the Indonesia Stock Exchange for the period of 2016-2018. The sampling technique in this study used a purposive sampling method and obtained a sample of 20 companies. The data analysis method uses the classic assumption test and multiple linear regression analysis using SPSS 20, with the results of data analysis showing that, debt to equity ratio and managerial ownership influence earnings growth. While the current ratio and total asset turnover has no effect on profit growth.
Keywords : Profit Growth, Current Ratio, Debt to Equity Ratio, Total Aset Turnover, Managerial Ownership
الكاكائية أصولهم وعقائدهم
Authors: Khurshid Rozhan I. , Qarany Ismail M.
Published: March 2021

تبحث هذه الدراسة عن الأقلية الكاكائية التي تسكن غالبها في كردستان العراق، وهي مأخوذة من كلمة كاكه الكردية للدلالة على وجود الاحترام والتقدير والأخوة فيما بينهم أو بينهم وبين شيخهم، ودراسة الموضوع هذا مهم لاسيما للكرد المسلمين الذين يعيشون بجانبهم ولهم احتكاك بهم، وتعد الغموض في أصول هذه الديانة من أهم مشاكل هذه الدراسة، وقد اعتمدنا في البحث على المنهج الاستنباطي في أخذ الموضوعات المدروسة، مع نقل الآراء وعزو الأقوال معتمداً على المصادر الأصلية، والدقة فيها، مع اتباع المنهج التحليلي لما ننقلها. وتطرقنا إليهم من حيث تسمياتهم وأسبابها، وتاريخ نشأتها، وبيان الآراء حول من أسسها، وأصول عقيدتها وشعائرها ومقدساتها، ومواطن تواجدها، وذلك بالرجوع إلى الكتب المؤلفة عنها والدراسات التي تطرقت إلى بيانها، دراسة موضوعية تاريخية وعلمية، وفي الخاتمة استعرضت أهم ما توصلت إليه من نتائج
Synthesis of Four-arms Star-shaped PCL-b-PEG as a Potential Amphiphilic Hydrogel
Authors: Ismail Wafiuddin , Wan Abdul Khodir Wan Khartini , Abd Hamid Shafida , Daik Rusli
Published: March 2021

Hydrogel formulations have drawbacks in delivering hydrophobic drugs which can affect its efficiency. Introducing amphiphilic system into hydrogel can overcome this limitation and increase hydrogel effectiveness as a drug cargo. In this study, four arms star-shaped block copolymers with polyethylene glycol (PEG) as hydrophilic block and polycaprolactone (PCL) as hydrophobic block were synthesized via a combination of ring-opening polymerization (ROP) and Steglich esterification. The structures were confirmed by 1H-NMR and FTIR analysis. The polydispersity index (PDI) indices from gas permeation chromatography (GPC) were 1.3 to 1.6 suggesting controlled polymerisation reaction occurred. Average molecular weight analysis, Mn based on 1H-NMR are close to the theoretical value. However, there is a slight difference of Mn between GPC and proton analysis due to the ability of GPC determining Mn for the star-shaped polymer. Both star-shaped polymers possesses high thermal stability (>350 °C) based on thermal decomposition study using TGA analysis. The presence of PEG had increased the hydrophilicity and solubility of the PCL in the hydrogel since an opaque homogeneous formulation form when using the amphiphilic star-shaped polymer. The pH (7.25 ± 0.03) and viscosity (9330 cP) of the formulation are set within the compatibility and suitable for human skin and topical application.
Representasi Budaya Termarginalisasi dalam Game
Authors: Yonathan Orville , Paramita Sinta
Published: March 2021

Games as a form of mass communication carry messages for the audience. One of the games called marginalization was Player Unknown's Battlegrounds (PUBG). This study aims to identify the existence of marginalization in minority cultures in the PUBG game. The PUBG game is a survival game against 100 people where the players are placed on an island. How to survive is done by killing opposing players using the weapons that have been provided. This game can be done alone or in groups of four. The research method used by researchers is qualitative research methods. The research technique used is the Semiotic analysis of Roland Barthes. The data collection technique used was the observation technique. Observations made by researchers include how the characters in this game are made and how the forms of communication performed by the players while playing so that the marginalization of the minority culture appears. This study found that in an online game it has the potential to bring bad things to the intercultural society which is described by Roland Barthes that a bad habit will become a habit that is tolerated.Permainan atau game sebagai bentuk komunikasi massa membawa pesan bagi audiens. Salah satu game yang disebut melakukan marginalisasi adalah game PlayerUnknown’s Battlegrounds (PUBG). Penelitian ini ingin mengidentifikasi adanya marginalisasi pada budaya minoritas dalam game PUBG. Permainan PUBG merupakan permainan bertahan hidup dengan melawan 100 orang di mana para pemainnya ditempatkan di sebuah pulau. Cara bertahan hidup dilakukan dengan membunuh pemain lawan menggunakan senjata yang sudah disediakan. Permainan ini dapat dilakukan sendiri atau berkelompok dengan anggota empat orang. Metode penelitian yang dipakai peneliti adalah metode penelitian kualitatif. Teknik penelitian yang digunakan adalah analisis Semiotika Roland Barthes. Teknik pengumpulan data yang digunakan adalah teknik observasi. Pengamatan yang dilakukan peneliti meliputi bagaimana karakter dalam game ini dibuat dan bagaimana bentuk komunikasi yang dilakukan para pemain pada saat bermain sehingga muncul marginalisasi budaya minoritas tersebut. Penelitian ini menemukan bahwa di dalam sebuah game online memiliki potensi memunculkan hal buruk untuk masyarakat antar budaya yang digambarkan menurut Roland Barthes bahwa sebuah kebiasaan buruk akan menjadi suatu kebiasaan yang ditoleransi.
Komunikasi Pemasaran UMKM dalam Beradaptasi di Masa Pandemi Covid-19 (Studi Kasus Hello Cafe)
Authors: Ambar Ruth , Sari Wulan Purnama
Published: March 2021

Since the pandemic outbreak hit Indonesia, the most visible impact is the economic crisis. One of those affected was that UMKM (Micro, Small and Medium Enterprises) both in the service and production sectors experienced a significant decline in turnover, one of which is Hello Cafe. Hello Cafe will adapt to new circumstances, where business premises can reopen by complying with existing health protocols. Hello Cafe must be able to carry out proper marketing communications so that customers can come back to visit to improve their turnover and losses. The purpose of this research is to find, understand, and describe what marketing communications will be used appropriately at Hello Cafe to adapt to the covid-19 pandemic. Researchers chose to use a qualitative approach because they will conduct research and analysis on the phenomenon of marketing communication at Hello Cafe during the Covid-19 pandemic. The conclusion of this study is that effective marketing communication in adapting during the Covid-19 pandemic is personal selling to invite old customers to come back to Hello Cafe and word of mouth because most visitors come from recommendations from old customers who have visited.Sejak wabah pandemi melanda Indonesia, dampak yang sangat terlihat adalah krisisnya perekonomian. Salah satu yang terkena dampaknya adalah UMKM (Usaha Mikro Kecil dan Menengah) baik dalam bidang jasa maupun produksi megalami penurunan omzet yang siginifikan, salah satunya adalah Hello Cafe. Hello Cafe akan beradaptasi dengan keadaan yang baru, dimana tempat usaha bisa kembali buka dengan mematuhi protokol kesehatan yang ada. Hello Cafe harus bisa melakukan komunikasi pemasaran yang tepat agar pelanggan dapat kembali berkunjung untuk memperbaiki omzet dan kerugian yang dialami. Tujuan penilitian ini adalah untuk menemukan, memahami, serta mendeskripsikan tentang komunikasi pemasaran apa yang akan digunakan secara tepat pada Hello Cafe untuk beradaptasi di masa pandemi covid-19. Peneliti memilih menggunakan pendekatan kualitatif karena akan melakukan riset dan analisis terhadap fenomena komunikasi pemasaran pada Hello Cafe dalam masa pandemi covid-19. Kesimpulan dari penelitian ini bahwa komunikasi pemasaran yang efektif dalam beradaptasi di masa pandemi covid-19 adalah personal selling untuk mengajak pelanggan lama kembali berkunjung ke Hello Cafe dan word of mouth karena kebanyakan pengunjung berdatangan dari rekomendasi pelanggan lama yang sudah berkunjung.
Analisis Potensi Lahan Desa Tanah Wulan Kecamatan Maesan Kabupaten Bondowoso Untuk Perkebunan Kopi Arabika dan Kopi Robusta
Authors:   Universitas Negeri Jember, Hanafi Mohamad Hamid Mahmud , Novita Elida ,   Universitas Negeri Jember, Andriyani Idah ,   Universitas Negeri Jember
Published: March 2021

Desa Tanah Wulan Kecamatan Maesan Kabupaten Bondowoso merupakan salah satu desa yang berada di lereng pegunungan Argopuro. Mayoritas penduduk di Desa Tanah Wulan berkerja sebagai petani kopi. Perkebunan kopi rakyat di Desa Tanah Wulan terletak lahan perhutani dengan ketinggian antara 600-1300 m dpl. Tujuan penelitian ini yaitu untuk mengetahui potensi lahan untuk tanaman kopi arabika dan kopi robusta, mengetahui status pengelolaan lahan untuk budidaya kopi di Desa Tanah Wulan, dan mengetahui kesesuaian jenis tanah untuk budidaya kopi di Desa Tanah Wulan. Metode yang digunakan yaitu dengan analisis ketinggian dan kelerengan lokasi perkebuanan dengan menggunakan sistem informasi geografis. Hasil dari analisis perkebunan kopi menggunakan metode sistem informasi geografis menghasilkan peta yang memuat beberapa informasi. Informasi tersebut berupa lokasi lahan yang berpotensi untuk dijadikan kebun kopi arabika dan robusta. Informasi tentang kondisi lahan tersebut disajikan dalam bentuk peta potensi lahan yang dapat dijakan sebagai acuan untuk membuka lahan baru untuk dijakan kebun kopi. Dari hasil analisis potensi lahan didapatkan hasil lahan yang berpotensi untuk perkebunan kopi arabika hanya terkelola sebanyak 49% sedangkan untuk lahan robusta sudah dikelola sebanyak 95%.
Keputusan Petani Dalam Alih Komoditas Tanaman Tembakau Ke Sayuran (Studi Kasus Kecamatan Pegantenan Kabupaten Pamekasan)
Authors:   Universitas Islam Madura, Nurmalasari Yanti , Awidiyantini Ruly ,   Universitas Islam Madura
Published: March 2021

Penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi perilaku petani dalam alih komoditas tanaman dari usahatani tembakau menjadi usahatani sayur-mayur di Desa Tlagah Kecamatan Pegantenan Kabupaten Pamekasan. Pemilihan lokasi ditentukan secara sengaja (purposive), yaitu berdasarkan pertimbangan bahwa banyak masyarakat Desa Tlagah yang melakukan alih fungsi lahan dari usahatani tembakau ke usahatani sayur mayur. Penelitian ini menggunakan metode survey dengan populasinya adalah semua petani yang melakukan alih fungsi lahan dari usahatani tembakau menjadi sayur mayur. Penentuan sampel dalam penelitian ini menggunakan metode purposive sampling (sampel bertujuan). Metode analisis menggunakan analisis LOGIT dengan menggunakan alat analisis SPSS (Statistical Produk and Service Solution). Hasil dari penelitian ini diketahui bahwa faktor yang mempengaruhi alih komoditas tanaman adalah usia, tingkat pendidikan, keikutsertaan kelompok tani, pekerjaan sampingan, dan tanggungan keluarga.
RANCANG BANGUN SARUNG TANGAN SEBAGAI ALAT BANTU TUNA NETRA BERBASIS SENSOR ULTRASONIC DAN ARDUINO NANO
Authors: Ramadhana Rahmat
Published: March 2021

Aksesibilitas adalah desain sebuah bangunan yang menjamin keamanan dan mudah dijangkau oleh semua orang dan tidak terkecuali, termasuk individu dengan disabilitas. Salah satu bentuk aksesibilitas adalah adanya guiding block atau ubin tekstur pemandu yang menjadi penunjuk jalan bagi pejalan kaki tunaneta di tempat umum. Akan tetapi guilding block yang sudah ada terkadang membuat penyadang tuna netra mengalami kecelakaan seperti tertabrak pot atapun tiang listrik.

Pada saat ini, alat untuk membantu penyandang tuna netra untuk melakukan aktivitas hanyalah sebuah tongkat yang memiliki panjang 120 cm, Tongkat tersebut memiliki keterbatasan seperti jangkauan alat, tidak dapat mendeteksi berbagai object di sekeliling penyandang dalam waktu yang cepat.

Pada penelitian ini akan dibuat sebuah alat berupa sarung tangan untuk membantu dan meringankan aktivitas seperti mengetahui object yang berada di depan para penyandang tuna netra tersebut. Dengan bantuan sensor ultrasonic kemudian di proses menggunakan Arduino nano. Dengan keluaran menghasilkan getaran dan suara yang berasal dari motor dc dan buzzer. Dapat memberitahukan seberapa dekat objek.

Hasil pengujian yang dilakukan sebanyak sepuluh kali dalam hal jarak dan delay pada tiga kondisi. Sarung tangan memiliki error yang kecil dalam hal pengukuran jarak tetapi memiliki error rate yang tinggi di setiap object. . Kemudian pada pengujian delay didapatkan perbedaan nilai yang sedikit pada object yang berbeda dan pada jarak tertentu dari satu hingga tiga meter didalam tiga kondisi.
Optical detection of quantum entanglement between two quantum dots mear a metal nanoparticle
Authors: He Yong , Zhu Ka-Di
Published: March 2021

We theoretically study the interaction between two semiconductor quantum dots (SQDs) and a metal nanoparticle\ (MNP) within the quantum description. The plasmon field produced in the MNP excited by the external field can play the platform of F\"{o}rster energy transfer between two SQDs which gives rise to the generation of entangled states. The Fano effect can be shown in the energy absorption spectrum of MNP, which originates from constructive or destructive interference between two competing optical pathways. Since the generated entangled state is in one pathway, the steady-state concurrence of entanglement can be evaluated by the observation of Fano profile. Because the concurrence of two SQDs is determined by both the pump intensity and the energy difference, one can properly choose these two parameters for detecting the non-negligible entanglement. When the pump intensity is very strong, there is no entanglement. The method to observe entanglement with the Fano profile, so, has a limited range of applicability. The optical observation is a novel approach to reveal entanglement. It may be used to optically detect quantum entanglement in many solid-state systems.
Cooling distant atoms into steady entanglement via coupled cavities
Authors: Shen Li Tuo , Chen Xin Yu , Yang Zhen-Biao , Wu Huai-Zhi , Zheng Shi-Biao
Published: March 2021

We propose a scheme for generating steady-state entanglement between two distant atomic qubits in the coupled-cavity system via laser cooling. With suitable choice of the laser frequencies, the target entangled state is the only ground state that is not excited by the lasers due to large detunings. The laser excitations of other ground states, together with dissipative processes, drive the system to the target state which is the unique steady state of the system. Numerical simulation shows that the maximally entangled state with high fidelity can be produced with presently available cooperativity.
To assess the drug safety and efficacy of sofosbuvir plus velpatasvir in hepatitis C patients
Authors: Nikhil Reddy C  , Bala Krishna K  , Narender Boggula  , Sadhana Kanukuntla  , Vasudha Bakshi  , Vivek Kumar Kunduru
Published: March 2021

Hepatitis is an inflammation of the liver. The condition can be self-limiting or can progress to fibrosis (scarring), cirrhosis or liver cancer. Hepatitis viruses are the most common cause of hepatitis in the world, but other infections, toxic substances (e.g. alcohol, certain drugs), and auto-immune diseases can also cause hepatitis. To assess the treatment efficacy of sofosbuvir and velpatasvir to chronic hepatitis C virus-infected patients and to assess the treatment efficacy among the various subgroups of the treated patients. The primary endpoint will be to assess sustained virologic response at 12 weeks (sofosbuvir + velpatasvir) after the end of therapy. The objective of the study is that hepatitis C virus is a rare viral disease occurring in the society with prevalence rate to be around 0.5% to 1.5%. So this study helps to assess the safety and efficacy of sofosbuvir and velpatasvir in hepatitis C virus-infected patients. This study is a prospective study. The study was carried in Gandhi Hospital, Secunderabad, Telangana, India, which is a multispecialty hospital with a bed capacity of 1200. The study is conducted in the Gastroenterology and Hepatology department (both inpatients and OP patients). The present study shows that sofosbuvir and velpatasvir provides a significant effect by decreasing HCV RNA levels, decreasing the duration of therapy and fewer adverse events compared to other existing therapies. Low incidence of side effects in the present study established the safety profile of the drug in 6 months period. In this study, most adverse events noticed were headache and fatigue. Sofosbuvir and velpatasvir yield the most favourable future health economic outcomes, compared with other currently available regimens across a broad spectrum of patients, including those with different treatments. Further elucidation of the side effects, a more extended period of sofosbuvir and velpatasvir and, more number of patients need to be studied.
Formulation and in-vitro evaluation of a transdermal patch loaded with letrozole
Authors: Kondapuram Parameshwar  , Suvendu Kumar Sahoo  , Rabinarayan Parhi  , Ravi Kumar V  , Ahad Ahmed kodipad  , Priyadharshini Selvaraj
Published: March 2021

The prime objective behind this investigation was to plan a Letrozole enclosed adhesive transdermal patch; since the transdermal route is an outright attractive option concerning its route, convenience and safety. Letrozole, a non-steroidal type II aromatase inhibitor, is reported for treating breast tumours and in postmenopausal women. In this study, few factors confined to formulation such as drug-in-adhesive, enhancers and amount of drug-loaded were investigated. The procedure used supposedly involves, the incarnation of the LET in phospholipids exploiting to a spray dryer. FTIR, X-RD, and DSC techniques which are used to evaluate entrapment efficiency were employed to LET spray-dried powder (LT-SDP). The molecule size, polydispersity file, and the EE were allegedly found to be 284.0 nm, 0.247 and 59.08%. On adding LT-SDP to a cream base with peppermint and olive oil as regular infiltration, the optimized formulation showed superior skin targeting in both in vitro and in vivo observations post-study.In vivo bioavailability studies showed just about four-fold increment in the plasma whereas the mean residence time and half-life were reasonably higher as compared to the LET cream in plain. The in vivo results observed remarkable patch concurrence with the plasma fixations anticipated from the in vitro infiltration. As an outpatient convenience, avoidance of gastrointestinal incompatibility provides suitability for self-administration for breast cancer prevention and treatment.
Determination of efficacy of the cellular cardiomyoplasty, using navigation system NOGA XP
Authors: Estrin S. І. , Kravchenko T. V. , Pechenenko A. R.
Published: March 2021

Objective. Improvement of the treatment results in patients with refractory angina, complicated by the heart insufficiency, using new methods of correction of the heart pumping function elaborated.

Materials and methods. Clinical investigation was performed, basing on retro- and prospective analysis of the treatment results in 156 patients: efficacy of myocardial remodeling was studied, using mesenchymal stem cells in patients, suffering refractory angina. For determination of the cellular therapy efficacy a navigation system NOGA XP was applied.

Results. There were presented the results of investigation of efficacy of intravenous injections of autologous mesenchymal stem cells to patients, suffering refractory angina, complicated by lowering of the heart pumping function, and immediate results of cardiomyoplasty using stem cells as well. For the first time a navigation system NOGA XP for determination of myocardial hibernation zones was applied in patients, suffering refractory angina. Also, using navigation system NOGA XP, the results of cellular cardiomyoplasty were obtained, while comparing electro-mechanical schemes before and after cellular therapy.

Conclusion. There was established the improvement of indices of the heart pumping function and the patients’ quality of life.
Cytoreductive surgery and hyperthermal intraperitoneal chemoperfusion in colorectal cancer and cancer of ovaries: our experience and perspectives of a new method
Authors: Malynovskyi A. V. , Grubnik V. V. , Gladchuk I. Z.
Published: March 2021

Objective. Studying of results of the cytoreductive operations and hyperthermal intraperitoneal chemoperfusion application for treatment of canceromatosis in colorectal cancer and ovarian cancer.

Materials and methods. In 10 patients, suffering colorectal cancer (6 men and 4 women) were performed peritonectomy, diathermo-ablation of implants, made from visceral peritoneum. Average value of the peritoneal canceromatosis index have constituted 18 (14 - 21). In 11 patients, suffering ovarian cancer, panhisterectomy, peritonectomy, omentectomy, and ablation of the visceral peritoneum implants was conducted. Median value of the peritoneal canceromatosis index was 16 (12 - 20). For hyperthermal intraperitoneal chemoperfusion oxaliplatin was used.

Results. Complete and optimal cytoreduction (degree CC0-CC1 in accordance to classification of P. H. Sugarbaker) was achieved in 5 patients, while suboptimal one (degree CC2) - in 10, and nonoptimal (degree CC3) cytoreduction - in 6 patients. Intraoperative complications were absent. Postoperative complications have occurred in 5 (23.8%) patients: the wound infection, persisting ileus, episode of partial ileus. Of 10 patients, suffering colorectal cancer, 5 died in 9-12 mo. One-year barrier have had survived 45.5% patients. Of 11 women-patients, suffering ovarian cancer, 7 died in 6-24 mo. One-year barrier have had survived 36.4% women-patients.

Conclusion. In patients, suffering colorectal cancer, the survival median was 12 mo, while in the women-patients, suffering ovarian cancer - 18 mo. Cytoreductive operations and hyperthermal intraperitoneal chemoperfusion constitute perspective method for the survival enhancement in patients, suffering canceromatosis, but only if their selection was organized.
Clinical and biochemical manifestations of undiagnosed Hashimoto’s thyroiditis
Authors:   Alfred Health, Melbourne Australia
Published: March 2021

We report the case of a 69 year old female who presented with mild cognitive impairment and difficulty mobilising in the setting of profound hypothyroidism secondary to Hashimoto’s thyroiditis with associated elevated creatine kinase (CK), hyponatraemia, anaemia, renal impairment, hypercholesterolaemia and hypertryglyceridaemia. On initial investigations the patient had a thyroid stimulating hormone (TSH) of 49 mU/L, free T4 <5.4 pmol/L, thyroid peroxidase (TPO) antibody positive, CK 1628 units/L, sodium 120 mmol/L, haemoglobin 87 g/L, creatinine 109 mcmol/L, total cholesterol 8.1 mmol/L and tryglycerides 4.7 mmol/L. On examination the patient had no features of myxoedema coma but was found to have delayed relaxation of tendon reflexes, puffy facies with loss of outer one third of eyebrows, coarse hair, brittle nails and slowing of speech and movement with obvious cold intolerance. There was no muscle weakness on examination to suggest myositis although the patient complained of generalised aches and lethargy. The patient was initially treated with 100mcg oral thyroxine daily however this was increased and oral liothyronine introduced following an inadequate improvement. Eleven days post admission the TSH was 6.26 mU/L and the free T4 was 12.4pmol/L following a total of 1500mcg oral thyroxine replacement and 60mcg oral liothyronine replacement. The hyponatraemia improved with a strict fluid restriction of 500 millilitres daily to sodium 133 mmol/L and the renal function improved to a creatinine of 70 mcmol/L on discharge. Atorvastatin was withheld due to the elevated CK which improved to 370 units/L and the anaemia remained stable throughout the admission. Although the patient refused formal cognitive assessments her functional abilities improved with treatment. This case highlights the clinical and biochemical features of severe hypothyroidism in the setting of undiagnosed Hashimoto’s thyroiditis.
THE INFLUENCE OF THE PRINCIPAL'S MANAGERIAL ABILITY, TRAINING AND SPIRITUAL INTELLIGENCE ON TEACHER PERFORMANCE AT SMPN 1 RANTEPAO
Authors: Timang Meti , Nadeak Bernadetha , Sihotang Hotmaulina
Published: March 2021

The purpose of this study was to find out the influence of the headmaster's managerial ability on teacher performance, the influence of Teacher Spiritual Intelligence on Teacher performance, the influence of Teacher Training on student achievement, the influence of the principal's managerial ability, teacher training and spiritual intelligence on teacher performance at SMP Negeri 1 Rantepao.  The method used in this research is a research method that is more towards the objective measurement aspect of social phenomena. The results showed that referring to the results of double linear regression analysis, and it can be concluded that managerial ability, training and spiritual intelligence have a significant and positive effect on teacher performance at SMP Negeri 1 Rantepao, meaning that if managerial ability, training and spiritual intelligence improve then the performance of teachers at SMP Negeri 1 Rantepao increased.
Tobacco use and COVID-19 in Ghana: generating evidence to support policy and practice
Authors: Singh Arti , Logo Divine Darlington , Dobbie Fiona , Ralston Rob , Davidson Fiona , Bauld Linda , Owusu-Dabo Ellis
Published: March 2021

Background

The COVID-19 pandemic has affected over 45 million people and caused over a million deaths globally. Tobacco use, a threat to public health worldwide, increases the risk of developing severe COVID-19 disease and death. The hand-to-mouth action, smoking-induced lung diseases, and the sharing of tobacco products such as water pipes, increase a smoker’s vulnerability to COVID-19. Implementation of tobacco control efforts in low- and middle-income countries (LMICs) including sub-Saharan Africa (SSA) is a particular challenge. The aim of this study in Ghana was to produce evidence to support governments to make informed policy decisions about tobacco control interventions in the context of COVID-19.

Methods

A survey with key stakeholders (conducted online or via face to face interview) and a desk-based mapping of data sources including government reports and online print press. Face-to Face interviews followed the COVID-19 precautionary protocols.

Results

40 stakeholders participated in the interviews (28 online and 12 face-to-face). 46 data sources were identified from the mapping of which 16 were eligible for data extraction. Over two fifths of survey respondents (42.9%, n=12) agreed that the relationship between COVID-19 and tobacco use had been discussed in the media, and over half (57%, n=16) reported that public health professionals and other authorities had provided advice to tobacco users during the pandemic. While respondents (89%, n=25) did not see a change in the level of interest in tobacco cessation, less than a quarter (23%, n=6) indicated that the policy response to COVID-19 included a focus on tobacco control issues, but was limited to tobacco cessation. The majority of respondents (77%, n=31) reported a perceived limited impact on the tobacco industry’s operations during the pandemic.

Conclusions

COVID-19 provides a timely opportunity to strengthen tobacco control efforts by recognizing the role of tobacco use in potentially exacerbating covid-19 health outcomes and promoting cessation.
PENINGKATKAN HASIL BELAJAR PASSING BOLA BASKET MELALUI GAYA MENGAJAR CAKUPAN SISWA SMP KATOLIK AMBON
Authors: Ivakdalam Falentina
Published: March 2021

Kurangnya pemahaman siswa tentang dasar-dasar passing bola basket mengakibatkan kurangnya pengusahan teknik dasar  passing dan bagaimana cara menangkap bola yang dilemparkan atau dipasing pada saat dalam permainan berlangsung. Melihat hal tersebut diatas maka penulis merasa tertarik untuk meneliti masalah tersebut menjadi suatu objek penelitian dengan judul “ Meningkatkan hasil belajar bola basket melalui gaya mengacar cakupan siswa SMP Katolik Ambon. Berdasarkan hasil penelitian di atas, maka hasil belajar passing bola basket dengan menerapkan gaya mengajar cakupan hasilnya sangat baik. Hal itu tampak pada pertemuan pertama dari 20 orang siswa yang hadir pada saat penelitian ini dilakukan, nilai rata-rata mencapai 65,16% meningkat menjadi 79,69%.
Коронакризис – кризис управленческих решений
Authors: Веселова Э. Ш.
Published: March 2021

Статья написана на базе материалов нескольких онлайн-се-
минаров и конференций, прошедших летом-осенью 2020 г. и посвященных
обсуждению проблем, вызванных пандемией COVID-19. Экономисты пришли
к выводу, что первый в истории опыт локдауна, порожденный желанием оста-
новить распространение инфекции, спровоцировал тяжелейший экономический
кризис, который один из экспертов назвал кризисом управленческих решений.
Авторы процитированных в статье докладов сходятся во мнении, что для успеш-
ного преодоления последствий коронакризиса многим государствам стоило бы
кардинально пересмотреть сложившиеся подходы к управлению экономикой.
Экономическая доступность продовольствия: региональные и социальные различия
Authors: Калугина З. И.
Published: March 2021

В статье обсуждаются проблемы, связанные с экономической доступностью продовольствия, которая понимается как возможность приобретения продуктов питания по сложившимся ценам, обеспеченная соответствующим уровнем доходов населения. Выявляются региональные и социальные различия этого показателя. Чрезвычайно важным фактором обеспечения экономической доступности продовольствия является наращивание отечественного производства, в части которого выявлена положительная динамика. Установлено, что по основным группам продуктов питания страна достигла продовольственной безопасности. Показано, что первоочередной задачей на пути повышения экономической доступности пищевых продуктов для всех групп населения является борьба с бедностью. Однако предпринимаемые в этом направлении меры, судя по статистическим данным, не приносят ощутимых результатов.
Что такое «сверхкомбинат»?
Authors: Никольский А. Ф.
Published: March 2021

Дается определение понятия «сверхкомбинат» как поточной линии макрорегионального уровня, предназначенной для производства рекордных объемов той или иной продукции. Понятие впервые введено автором при разработке проекта «Новый Ангарстрой: Байкало-Амурский металлургический сверхкомбинат». Проект возобновляет традиции разработки комплексных интеграционных проектов территориального развития России на уровне экономических районов и их сопряжений, объединяющих в себе множество субъектов Федерации. Неверно, когда единицами общероссийского территориального планирования служат конкурирующие за инвестиции субъекты Федерации, часто предлагающие одни и те же дублирующие друг друга мелкие, местные проекты на ресурсах общероссийского и даже мирового значения. Всякий крупный проект общероссийского масштаба, подобно Урало-Кузнецкому комбинату прошлого и предложенного Байкало-Амурскому металлургическому сверхкомбинату будущего, всегда объединяет в себе множество субъектов Федерации, причем каждый по-своему, на основе его главных для данного общероссийского проекта ресурсов.
Восстановление и развитие промышленности Новониколаевска-Новосибирска в годы Новой экономической политики
Authors: Кокоулин В. Г.
Published: March 2021

В статье рассматриваются проблемы восстановления и развития промышленности в Новониколаевске (Новосибирске) в годы Новой экономической политики (1921–1929 гг.). Отмечается противоречивая политика власти по отношению к разным формам собственности в промышленности (государственной, кооперативной, частной) в этот период. Анализируются основные проблемы, которые не позволяли повышать производительность труда – безработица, условия труда и уровень заработной платы, отношение рабочих к политическим и экономическим мероприятиям власти. Автор приходит к выводу, что сворачивание нэпа было развитием одной из тенденций, которые были присущи этой политике.
К столетию Новой экономической политики. Интервью с Г. И. Ханиным
Authors: Клисторин В. И.
Published: March 2021

Интервью со статистиком и специалистом в области экономической истории доктором экономических наук Г. И. Ханиным посвящено обсуждению одному из наиболее спорных периодов развития отечественной экономики, а именно Новой экономической политики (нэпа), провозглашенной 100 лет назад. Дискуссии среди экономистов ведутся как вокруг глубины и последовательности реформ, проводившихся в 1920–1929 гг., так и их эффективности. Часть экономистов связывают быстрый экономический рост в этот период с эффектом низкой базы (восстановительный рост) и обосновывают неизбежность отказа от политики нэпа. Другие доказывают, что продолжение этой политики было бы плодотворным для отечественной экономики и индустриализация страны могла быть осуществлена с меньшим числом жертв и более органично. К тому же последующие экономические реформы в СССР и других социалистических странах в определенной мере опирались на опыт нэпа.
Методи оцінювання літаків первинної льотної підготовки як багатовимірних об'єктів з врахуванням важливості їх ознак
Authors: Шевяков Ю.І.
Published: March 2021

Розглянуто і розв’язано задачу вибору літака первинної підготовки із застосуванням метода мультиплікативної згортки кількісних характеристик літаків первинної підготовки та метода, заснованого на таксонометричному підході. Запропоновано модифікації цих методів шляхом врахування коефіцієнтів важливості кількісних характеристик літаків: льотні якості літака (придатність до первинного льотного навчання), безпека, економічні показники (вартість літака, вартість експлуатації та технічного обслуговування) та технічний супровід. У якості прикладу розглядаються шість літаків з ілюстративними даними щодо кількісних характеристик літаків.
Параметри причорноморських тропосферних радіохвилеводних каналів виявлення безпілотних літальних апаратів
Authors: Леушин С.Г. , Бєсова О.В. , Олещук М.М.
Published: March 2021

Показано, що існують кілька моделей тропосферних каналів поширення радіохвиль. Найбільш поширеними моделями є: багатоканальні параметричні пристрої з випадковими параметрами за часом і багатосмугові параметричні фільтри з випадковими параметрами по частоті. Однак на практиці існує апріорна невизначеність характеристик променів поширення, як за часом, так і по частоті, обмежує значимість цих моделей. Проаналізовано модель багатопроменевого каналу радіолокації з випадковими параметрами за часом і по частоті. Визначено параметри моделі - середній часовий інтервал і середнє частотне рознесення. Показаний їх зв'язок з смугою і час когерентності каналу. Наведено кількісні оцінки смузі і часу когерентності для причорноморських районів. Отримані результати можуть служити основою для синтезу та аналізу РЛС виявлення безпілотних літальних апаратів (БПЛА), що працюють в умовах багатопроменевого поширення електромагнітних хвиль (ЕМХ).
Association of door-to-balloon time and clinical factors with hospital shifts
Authors: Merini Filipe , Felippe André , Silva Roberto , Fattah Tammuz , Moreira Daniel
Published: March 2021

Background: In ST-segment elevation myocardial infarction, the main therapy is early arterial reperfusion, performed by primary percutaneous coronary intervention. The recommended door-to-balloon time is <90 minutes. The objective of this study was to associate the door-to-balloon time and clinical factors with hospital shifts. Methods: This was a cross-sectional observational study, part of the Catarina Heart Study. We analyzed patients diagnosed with ST-segment elevation myocardial infarction in hospitals of the metropolitan area of Florianópolis, from 2016 to 2020. The qualitative variables were analyzed using the Chi-square test, and the quantitative variables were analyzed using the Student’s t test and Mann-Whitney test. Results: A total of 318 patients were analyzed, with a mean age of 58.7±11.4 years, predominantly male (71.7%) and hypertensive (53.7%). The median door-to-balloon time was significantly lower in the group seen on weekdays compared to the group seen on weekends, respectively, 71.0 (51.0-126.0) minutes and 91.0 (71.0-123.0) minutes (p=0.028). There was no difference in the door-to-balloon time in the night shift and in off-hours. Individuals undergoing primary percutaneous coronary intervention during the night shift showed a non-significant tendency for higher mortality rates from any cause (1.9%) compared to those seen during the day shift (0.0%; p=0.057). Conclusion: Patients with ST-segment elevation myocardial infarction seen on weekdays have shorter door-to-balloon time.
UKRN Statement on Responsible Research Evaluation
Authors: Network Reproducibility
Published: March 2021

UKRN Common Statements: Statement on Responsible Research Evaluation
Arahan Pengembangan Destinasi Wisata Kawasan Kaldera Batur Berbasis Sistem Informasi Geografis (SIG)
Authors: Suprapto Nyoman Arto
Published: March 2021

Kawasan Kaldera Batur memiliki beragam potensi pengembangan wisata namun juga sangat dibatasi pengembangannya karena kawasan ini ditetapkan sebagai kawasan konservasi di dalam rencana tata ruang Kabupaten Bangli dan Provinsi Bali. Pengembangan Kawasan dilakukan untuk mengkomodasi kepentingan ekonomi masyarakat namun sekaligus juga menjaga fungsi lindung kawasan tersebut. Dualisme fungsi kawasan tersebut mengharuskan adanya sebuah pendekatan yang yang tepat dalam mengembangkan destinasi wisata Kaldera Batur agar tercapai pembangunan pariwisata yang berkelanjutan. Salah satunya adalah pengembangan destinasi wisata berbasis Sistem Informasi Geografis (SIG). Arahan pengembangan destinasi wisata khususnya penyediaan fasilitas pariwisata pada Kawasan Kaldera Batur dilakukan dengan pendekatan kemampuan lahan yang dianalisis dengan Teknologi SIG. Berdasarkan hasil analisis ditemukan bahwa kelas kemampuan lahan pada Kawasan Kaldera Batur yang cocok untuk pengembangan fasilitas penunjang pariwisata adalah Kelas D dan E yaitu kelas lahan dengan kemampuan pengembangan agak tinggi dan tinggi seluas 14.096 Ha yang tersebar di Desa Batur Tengah, Batur Selatan, Songan A, Sukawana dan Abangbatudinding.
PPP1R35 is differentially expressed in the lymph node metastases of patients with breast cancer.
Authors: Mamoor Shahan
Published: March 2021

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the breast and the brain reside the secondary lymphoid organ, the lymph nodes. We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the lymph nodes in humans with metastatic breast cancer. We found that protein phosphatase 1 regulatory subunit 35, PPP1R35, was among the genes whose expression was most different in the lymph node metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. Analysis of a separate microarray dataset revealed that PPP1R35 was also differentially expressed in brain metastatic tissues (5). PPP1R35 mRNA was present at increased quantities in lymph node metastases as compared to primary tumors of the breast. Importantly, expression of PPP1R35 in primary tumors of the breast was correlated with patient post-progression survival, in lymph node positive patients but not in lymph node negative patients. Modulation of PPP1R35 expression may be relevant to the biology by which tumor cells metastasize from the breast to the lymph nodes and the brain in humans with metastatic breast cancer.
UKRN Statement on Transparency in Research
Authors: Network Reproducibility
Published: March 2021

UKRN Common Statements: Statement on Transparency in Research
Evolution of reading and face circuits during the first three years of reading acquisition
Authors: FENG Xiaoxia , Monzalvo Karla , Dehaene Stanislas , Dehaene-Lambertz Ghislaine
Published: March 2021

Although words and faces activate neighboring regions in the fusiform gyrus, we lack an understanding of how this category selectivity emerges during development. To investigate the organization of reading and face circuits at the earliest stage of reading acquisition, we measured the fMRI responses to words, faces, houses, and checkerboards in three groups of 60 children: 6-year-old pre-readers, 6-year-old beginning readers and 9-year-old advanced readers. The results showed that specific responses to written words were absent prior to reading, but emerged in beginning readers, irrespective of age. Likewise, specific responses to faces were weak or absent in pre-readers, but they emerged more slowly and continued to evolve in the 9-year-olds, primarily driven by age rather than by schooling. Crucially, the sectors of ventral visual cortex that become specialized words and faces harbored their own functional connectivity prior to reading acquisition: the VWFA with left-hemispheric spoken language areas, and the FFA with the contralateral region and the amygdalae. The results support the view that reading acquisition occurs through the recycling of a pre-existing but plastic circuit which, in pre-readers, already connects the VWFA site to other distant language areas. Furthermore, reading acquisition does not compete with the face system directly, through a pruning of preexisting face responses, but indirectly, by partially reorienting the slow growth of face responses to the right hemisphere.