bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of Individual Differences in Translator Training
Authors: Zhou Xiangyan , He Xiaozhi
Published: August 2023

Translation is a complex process in which individual differences may impact students’ translation performance.However, there needs to be more empirical research on this topic. This study aims to investigate how affective andcognitive factors are related to the translation speed and quality of student translators through bibliometric analysis. Thestudy focuses on the following four factors: self-efficacy, anxiety, language proficiency, and working memory, which arehighly associated with translation performance. Among them, self-efficacy and anxiety were defined as affective factors,while language proficiency and working memory as cognitive factors. The results show that the four factors playedan essential role in translation. The study implies that great attention shall pay to the role of individual differences intranslator training.
Abundance of T Stem Cell Memory in F-CAR-T Cells CausingYounger Phenotypes
Authors: Huang Xing
Published: August 2023

This study will introduce a novel anti-CD19 CAR-T technology – FasT CAR-T (F-CAR-T)- shortens production time,increases production quality, and produces healthier T cells with a younger phenotype. This study also investigates theeffect of the abundance of T stem cell memory in F-CAR-T cells’ correlation with younger phenotypes, leading to betterpersistence in T cells by manipulating the number of Car T cells injected into Raji xenografts. Using mouse cell lines,RAJI xenograft models, and F-CAR-T cells, this study will measure cell proliferation of Tscm, CD45RO-, CD62L+,and PD1/Lag3/Tim3 by flow cytometry and count Car expressing cells using SCFV antibodies. The experiment resultswill show if F-CAR T cells have significantly greater expansion and T stem cell memory than C-CAR-T cells. TheC-CAR-T cells with less exhaustion, indicating the effect of T stem cell memory distinguishing F-CAR-T therapy fromconventional CAR-T therapy. The result of this study will provide critical information for the future clinical trial ofF-CAR-T cell therapy. This work can inspire to utilize the T stem cell memory, which exhibits great antitumor activity,to explore the mechanism of modulation of CAR-T cell metabolism and T cell differentiation.
Curative Effects of Traditional Chinese Medicine Quercetin in theTreatment of COVID-19 through Inhibiting Viral S-proteins of SARSCoV-2 from Binding to its ACE-2 Receptor
Authors: Wang Xiao Shannon
Published: August 2023

SARS-CoV-2 is the virus that causes COVID-19, an infectious respiratory disease that broke out internationally atthe beginning of 2020. SARS-CoV-2 enters its host cell as Spike (S) proteins bind to its ACE-2 receptor. Quercetin,a type of Traditional Chinese Medicine (TCM), has been shown by previous literature to have inhibitory effects inthis pathway. However, quercetin has low bioavailability, and there is little literature on whether quercetin can lead toinhibitory effects in in-vivo conditions. This study will investigate whether SARS-CoV-2 will be inhibited from bindingto its ACE-2 receptor in Syrian hamster cell lines if (1) quercetin is applied alone, (2) bromelain, a dietary supplementthat can also increase quercetin’s bioavailability, is applied alone, and (3) quercetin and bromelain are both applied. Thisstudy will use RT-qPCR and surface plasmon resonance (SPR) to measure the inhibitory effects of any of the treatmentsin this pathway and UV spectrophotometry to measure the solubility of the treatments in saline solution.
Potential Treatment of Non-Small Cell Lung Cancer by UpregulatingZinc Finger Protein 671 Expression
Authors: Liang Rui , Shan Sicong , He Xi , Li Brain , Zhou Hanru
Published: August 2023

Non-small cell lung cancer (NSCLC) is the most common type, with a high mortality rate. It is often diagnosed at anadvanced stage, which causes treatment difficulties due to a lack of symptoms at early stages. Here, we propose a newapproach for treating NSCLC via upregulating zinc finger protein 671 (ZNF671) expression. Firstly, we will reduce thedegree of methylation at its gene promoter site in the NSCLC tumor cells. Secondly, the RT-qPCR technique is usedto compare the expressions of ZNF671 between different methylation statuses; in vitro cell viability, proliferation, andinvasion assays are applied to test the effects of demethylation in tumor cells. Finally, the patient-derived xenografts(PDX) model is used to observe the effect of regulating methylation status on the expression of ZNF671, affecting tumorgrowth in vivo.
The development status and future of the field effect transistor
Authors: Yang Zhibo , Wu Jizhou
Published: August 2023

FET is short for Field Effect Transistor (FET). There are two main types: Junction FET-JFET and metal-oxideSemiconductor FETs (MOS-FETs). Conduction by the majority of carriers, also known as a monopolar transistor. Itis part of voltage controlling semiconductor device. With the advantages of high input resistance (107 ~ 1015 Ω), lownoise, low power consumption, extensive dynamic range, easy integration, no secondary breakdown phenomenon, andwide safe working area, it has become a strong competitor of bipolar transistors and power transistors
Astragalus Mongolians' Suppression of HBV DNA Level in ChronicHepatitis B (CHB) Patients with Moderately Increased AlanineAminotransferase (ALT)
Authors: Tang Zilong
Published: August 2023

This paper aims to examine the impact of Astragalus on the quantity of HBV DNA in chronic hepatitis B (CHB) patientswith slightly raised ALT and the effect on IFN-G. Moreover, the work predicted that IFN-gamma would increase aftertaking Astragalus Mongolians in CHB mouse patients with mildly raised ALT and effectively suppress the amount ofHBV DNA. Three groups of mice were set up, including a positive control group, a negative control group, and a groupof mice with mildly elevated ALT, which are more significant than one to two times the upper limit of normal (1-2 timesULN) and carrying CHB. Astragalus was administered to mice previously infected with HBV in increasing doses andfor longer lengths of time. Entecavir was a positive control, while PBS + DMSO was the negative control. IFN-g in theblood was detected using an ELISA test, and HBV DNA was determined using RT-PCR. The six possible results in thispaper correspond to the reaction of CHB-carrying mice with mildly elevated ALT to Astragalus. Whether the amount ofIFN-G and HBV DNA was elevated or reduced. The results of this paper will effectively predict the effect of Astragaluson the amount of HBV DNA in CHB-carrying mice with mildly raised ALT with several different outcomes. This paperalso analyzes the different outcomes and compares the changes in IFN-G; corresponding conclusions will be drawnbased on the different outcomes.
Diabet Prediction with Logistic Regression
Authors: Li Zijia
Published: August 2023

Diabetes is a common chronic disease that seriously challenges countries worldwide. However, there are problems suchas low detection rate, low awareness rate, low acceptance rate, and low treatment compliance rate in the diagnosis andtreatment process. This paper aims to construct a Logistic Regression Model to predict whether a patient has diabetesor not and to investigate the key factors that can be used to diagnose whether a patient has diabetes or not to promotethe development of diabetes treatment. The research results show that the patient’s characteristics, such as the numberof times prior, body mass index, and diagnostic measurements such as plasma glucose concentration 2 hours in anoral glucose tolerance test, trips skin fold thickness, 2-hour serum insulin, and diabetes pedigree function will have asignificant impact on whether the patient has diabetes. Therefore, the above six variables should be focused on whendiagnosing diabetes mellitus.
Retrosynthesis
Authors: Jie Xiao , Jiang Daizhen , Wu Youbang
Published: August 2023

The American chemist Elias James Corey was awarded the 1990 Nobel Prize in chemistry for developing the theoryand methodology of organic synthesis. He called his method “retrosynthetic analysis,” a technique for simplifying thesynthesis of large complex molecules. He worked out and described in detail a new and fruitful systematic approach tosynthetic chemistry. He has synthesized over 100 substances, including ginkgolide B (a compound extracted from theginkgo tree and used experimentally to treat asthma) and prostaglandins (hormone-like compounds used to induce laborand treat infertility). Corey—Nobel Prize for Retrosynthetic Analysis
A Comparative Study on the Meaning of ChineseVerbs “ 洗/刷 ” and Korean Verb “ 씻다 ”
Authors: Chen Jingru
Published: August 2023

Polysemy verbs are common in Chinese and Korean, but this does not mean that corresponding words in the twolanguages possess the exact same meanings. Based on the example sentences in the dictionary and their daily usage, thispaper makes a comparative analysis of the similarities and differences in the basic meanings, extended meanings, andspecific usage between the Chinese verb “洗/刷” and the Korean verb “씻다”. In the basic meaning, “洗/刷” “씻다”share a common meaning of “making dirty things disappear”. However, their extended meanings are quite different, andthere exist complex corresponding relationships between them. In terms of usage, the Chinese word “ 洗 / 刷 ” is mostlyused to express negative emotions. For example, “ 洗 ” has the extended meaning of “robbing or killing” and “ 刷 ” hasthe extended meaning of “eliminating”. In contrast, “ 씻 다 ” is mostly used to express positive emotions and has theintention of “getting rid of injustice, misunderstanding and guilt”. In addition, from the field of their usage, “ 洗 / 刷 ” iswider than “ 씻다 ”, and it is commonly used in the field of science and technology
Quercetin Inhibits Colorectal Cancer by Enhancing Apoptosis viaPI3K/Akt Pathway
Authors: Tang Rou
Published: August 2023

CRC is the second leading cancer globally, with a high lethality rate. The primary treatment of CRC is still surgery andchemotherapy with limited therapeutic effects. Quercetin, a component of traditional Chinese medicine, has shown itsability to anti-tumor and induce cell apoptosis through PI3K/AKT signalling pathway. This study aims to figure out howconcentrations of quercetin and different treatment durations will influence the effects of induction of apoptosis. Theexperiments will use CL40 cells. Cell apoptosis is measured by flow cytometry, and cell growth by MTT assay. Thephospho-AKT level is measured by anti-p-AKT Western Blot. Our research will determine the relationship betweentherapeutic effects, drug concentrations, and treatment durations. Further studies on the side effects of quercetin andmethods to mitigate the side effects in the systematic use of quercetin should be done. Moreover, a more specificmechanism for the function of quercetin is waiting to clarify
The Effects of Mindfulness Breathing Training on BeijingInternational High School Teachers’ Mental Exhaustion
Authors: Ma Yiyun , Li Yile , Wang Chunxuan , Chu Luxi , Wang Boyang
Published: August 2023

More and more teachers at foreign schools are becoming weary due to the high demands of study and work, whichhurts their physical and mental health. This study aims to investigate the impact of mindfulness breathing trainingon the mental exhaustion of teachers in international high schools. Nine teachers from Beijing Futurecity Academywere recruited. This group employed mindfulness breathing exercises to alleviate their mental fatigue. It turns out thatmindfulness breathing training can assist teachers at international high schools in recovering from mental exhaustion.
The researching of the drugs of Cancer
Authors: Xie Dinghong
Published: August 2023

Nowadays, cancer is a severe problem in many countries. Moreover, Aspirin and Bleomycin are two kinds of anti-cancerdrugs. However, none of these two drugs can bring cancer under permanent control. There are remarkable differencesbetween Aspirin and Bleomycin because of their different mechanics driven by their chemical structure. How Aspirincan treat cancer is still uncertain. The paper uses physics laws, Equation of continuity to assume that Aspirin reduces therisk of cancer by decreasing the blood pressure in the blood vessel. As a result, there is less opportunity for a cancer cellto strike and be stuck on the vessel wall. Assumption also says that overusing Aspirin will cause hypotension due to thehigh blood flow velocity due to Poiseuille’s Law.
Silencing ERK Signaling Pathway in TNBC by Silencing BAG3
Authors: Fan Junbo
Published: August 2023

TNBC(Triple negative breast cancer) is cancer with a high mortality rate and recurrence rate. Other studies have shownthat overexpression of EGFR in TNBC is also associated with the overexpression of BAG3 and that silencing of BAG3will downregulate the expression of EGFR. This study investigates the possible molecular function of BAG3 in treatingTNBC by silencing BAG3, weakening the efficiency of the ERK signaling pathway in vivo and in vitro. The study willuse BT-549 human breast cancer cell lines, with negative control, a wild-type cancer cell, and positive control treatedwith YM-1. CRISPR knockout BAG3 will change the expression of BAG3 in the sample, while U0126 treatmentmaintains the silencing of the ERK signaling pathway. Using MTT assay and xenograft metastasis, the growth andmigration of cancer cells will be tested; the western blot result will show the molecular process after the inhibition ofBAG3. These results, collectively, can show whether or not a knockout of BAG3 can downregulate EGFR by weakeningthe ERK signaling pathway.
Creating a Connected Strategy for STEAM
Authors: Li Yiran
Published: August 2023

The paper comprehensively evaluates various aspects of Steam’s business strategy. It analyzes the current strategy,market positioning, and targeted customer segments, examining how the company builds and maintains customerrelationships. The paper delves into Steam’s value proposition and highlights the organization’s specific methods andtactics to execute its strategy effectively.Additionally, the paper explores Steam’s barriers and challenges, such as the problems associated with an abundanceof games and a lack of customer service. It assesses the current information flow throughout the customer journey andidentifies pertinent customer pain points.Lastly, the paper proposes a connected strategic solution that focuses on creating a curated offering customer relationshipthat can significantly increase user retention rate and assist the company in securing its position as the industry leader inPC games. Innovative revenue models and technological solutions are described in greater detail as part of the strategy.Following is a risk and benefit analysis of the proposed strategy.Understanding the current successes and limitations of Steam’s business strategy is essential for developing innovativeand realistic strategic solutions, strengthening Steam’s capacity to adapt, innovate, and maintain its market competitiveadvantage.
Upregulating the Expression of F-CAR-T Cells by Increasing theAmount of Tcm Cells in F-CAR-T Cells
Authors: Xiangli Xiuyuan
Published: August 2023

CAR-T cells are most known for protecting one’s immune system by attacking cancer cells. Usually, it is infused intothe patient’s body to provide treatment. When comparing F-CAR-T cells with C-CAR-T cells, F-CAR-T cells typicallyhave more Tscm cells. Thus, this study investigates the effect of upregulating Tscm cells in F-CAR-T cells using FACSfor CD45RO- and CD62L+. The experiments will use the expression of Tim3, LAG3, and PD1 and measure if F-CAR-Tcells can kill CD19-expressing RAJI cells by FACS for CD19 and Annexin V/PI through various durations and withvarious numbers of injected CarT. Then Tscm cells are measured by FACS for CD45RO- and CD62L+. Moreover,two special diets will be used as an experimental control to regulate the increase and decrease of Tscm cells. There aretwo most possible results: (1) Both the Tscm receptor and the diet will have a positive effect in terms of upregulatingTscm cells in F-CAR-T cells; (2) Both the mouse peritoneal macrophage and the diet will inhibit the growth of Tscmcells. The result of our study will provide important information for the future clinical trial of Tscm cell application andimprove CAR-T cells’ persistence. Future studies should focus on shortening the CAR-T cells manufacturing processesas well as exploring more applicable usages of Tscm cells in detail
Effects of Nicotine on the Progression and Metastasis of HumanOvarian Cancer cells by Exacerbating EMT
Authors: Zhao Wuyou
Published: August 2023

Does nicotine, a main constituent of toxicants in Cigarette Smoke, relate to EMT and contribute to the progression ofovarian cancer? Treat SK-OV3 xenograft mice with increasing nicotine and measure TGF-β in blood by ELISA assayand tumor cell metastasis by confocal microscopy, looking for cancer cells in the liver, bone, brain, stomach, ovary andthen measure xenograft tumor size by weight. A positive control is benzene treatment, and the negative control is PBS.The results will reveal the effects of nicotine on ovarian cancer cell proliferation, which will improve our understandingof the harm environmental toxicants can do to human health. At the same time, the physiological processes that lead tocarcinogenesis will also provide prevention awareness and treatment ideas for ovarian cancer caused by smoking.
Multipartite Dense Coding in Social Internet of Things
Authors: Zhang Yao
Published: August 2023

The world today is interconnected. As we live in the contemporary era, we will undoubtedly feel the importance of information interaction in all aspects. This kind of information interaction needs to be carried out or mediated. Quantum communication is a new way of information interaction that has been pushed to the forefront in the past decade. It not only has the low cost of traditional radio communication but also has the characteristics of long relay distance of optical communication system. Compared with these characteristics, the most important thing is that it has super high confidentiality. This is the most critical point in the information age. Dense coding is an important application of quantum information. It reflects the difference between quantum bits and classical bits in transmission, providing a reliable theoretical basis for improving the effectiveness of remote communication in the future. We discuss two kinds of extensions of the original dense coding. They respectively work for high-dimension and multipartite situations. We give the laws of the two attachments. In the high-dimensional system, we use the Bell state as the target state of any quantum state and realize the one-to-one correspondence between the entangled state and the Bell state. In multipartite space, we can find that the transformation results can form a dimensional space, and the quantum states obtained are one-to-one, corresponding to the classical bit states. In the multipartite system, we can get the transmitted information more efficiently and accurately by limiting data processing by partial senders. At the same time, this restriction will not reduce the amount of information transmitted initially. Therefore, this limited transformation can improve quantum computing power without damaging quantum states.
On Task-based Approach in Translator Training
Authors: Zhou Xiangyan , Wu Fei
Published: August 2023

With the advancement of globalization, market demand for versatile translation talents has expanded, which makestraditional teaching approaches less likely to meet market requirements than task-based teaching. This approach shiftsthe focus from teaching to learning. However, a systematic review of task-based teaching in translator training needsto be done, particularly a simultaneous analysis of its merits and demerits. As the key to appropriately applying thisapproach is to consider its merits and demerits, the current study adopted bibliometric analysis to analyze relevantjournal articles from the Web of Science. The results implied that task-based teaching could help cultivate versatiletranslation talents through careful design (e.g., tasks). Furthermore, its merits outnumbered its demerits. The currentstudy can provide a reference for future research on the role of task-based teaching in translator training.
Combined Usage of Navitoclax and A-1210477 to Treat AcuteLymphoblastic Leukemia
Authors: Wu Ruotong
Published: August 2023

Mcl-1 protein has been a key targeted therapeutic protein in treating acute lymphoblastic leukemia because of itsresistance to other previously known drugs. However, a newly synthesized chemical A-1210477 has proven to possessenough affinity to bind to the Mcl-1 protein and disrupt its normal function. As a result, scientists started to test thepotency of A-1210477 combined with other drugs to treat various cancers. This study will examine the effect ofA-1210477 and Bcl-2 inhibitor navitoclax combined to treat acute lymphoblastic leukemia Bal-KHc cell line both invitro by MTT and Annexin V/PI Facs as well as in vivo by measuring the tumor volume in xenograft.
Will Company’s Social Donation Impact it’s Stock Performance? Evidence from China
Authors: Ma Shijie
Published: August 2023

With increasing market attention to corporate Environment, Social and Governance (ESG) practice. Corporate social donation plays an important part in a firm’s stock performance. Through regression analysis, this study aims to determine the relationship between corporate social donation surprise and a firm’s abnormal stock return in the next few periods. I analyzed 484 Chinese public companies from A and B shares and obtained the social donation amount from 2010-2020. The results show a positive and significant relationship between corporate social donation surprise and the firm’s abnormal stock return in the next two years. The analysis also indicates corporate social donation’s impact is stronger after COVID-19. For robustness checks, the study utilizes reverse causality analysis and nonlinear regression. I find that there is little possibility of a reverse impact from the company’s abnormal stock return. In addition, the result suggests the impact of corporate social donation appears to be an inverse U-shape. I also examine the different impacts on different market conditions. The findings of this study provide evidence for previous literature and guidance for proper corporate social donations.
Methionine restriction improve insulin resistance by reducingmitochondria oxidative stress
Authors: Liu Mingyue , Meng Xiaotong , Zong Yiling , Niu Xingyu
Published: August 2023

Type 2 diabetes is a chronic metabolic disorder whose prevalence has been increasing steadily worldwide and is closelylinked to the epidemic of obesity. The most common features of Type 2 Diabetes are hyperglycemia, insulin resistance,and relative insulin deficiency. Insulin resistance refers to incorrect responses to insulin among cells whose physiologydepends on insulin, such as adipocytes and cardiomyocytes. Methionine is an essential amino acid, so it must beconsumed in the diet to avoid neurological impairment and visual symptoms caused by methionine deficiency. Thisprovides a potential explanation that methionine restriction can alleviate insulin resistance by regulating mTORC1. Thisstudy aims to investigate the effect of methionine restriction on insulin resistance and mitochondria oxidative stress.
Analysis of SME Stock Price Forecasting System Based on MachineLearning
Authors: Hou Ziju
Published: August 2023

In financial market development, various theories and hypotheses have been studied and analyzed through differentmethods to summarize stock prices, including random walk theory, efficient market hypothesis, and behavioral finance.Therefore, it is of great significance to combine the various algorithms of machine learning with the relevant theoriesof financial markets in quantitative finance. In the market economy, small and medium-sized enterprises(SMEs) absorbmany workers in society and play a huge role in production, innovation, and entrepreneurship, which determines theimportance of Chinese small enterprises in the financial market and stock market. Machine learning forecasts stockprices as a reference for SMEs and their investors. In other words, enterprises can adjust the direction and proportionof business promptly, and investors can also choose whether to invest according to the forecast results. In addition, thiswork shows that the forecasting effect of machine learning can meet the needs of investors and SMEs by comparing thestock price forecasting using the RM machine learning algorithm and comparing the forecasting results.The machine learning algorithms commonly used in quantitative finance are briefly introduced, and the random forestalgorithm’s application principle in forecasting the stock price direction is described. Specifically, the stock priceforecasting system is built on the platform of Python, the logic of the system is explained, and the feasibility of thesystem is explained through experiments and analysis, which reflects the advantage of machine learning in forecastingthe stock price direction, and provides a new path for SMEs to forecast the stock price.
Inhibitory effect of N-oxalylglycine on gastric cancer cells
Authors: Zhu Zhechen
Published: August 2023

Some surveys have shown the possibility of controlling the growth of cancer cells by decreasing the content of 2OGoxygenase with NOG. This research aims to supply the blank of whether the anti-cancer ability of NOG exists in vitroand xenografted mice and how this ability is formed. Use human gastric cancer cell lines, SGC7901. They have broughtNOG, MTT, and cisplatin from different companies separately. Choose 60 male BALB/c Nude mice aged four weekswith an average weight of 15 – 20g as the experimental subject. Measure killing by MTT assay and tumor shrinkagein an SGC-7901 xenograft mouse and 2OG oxygenase by western blot. The possible results are: (1) NOG restrainsSGC7901 cells’ growth by inhibiting the abundance of 2OG oxygenase. (2) NOG can restrain the growth of SGC7901cells, but the principle differs from inhibiting the abundance of 2OG oxygenase. (3) NOG cannot restrain the growth ofSGC7901 cells.
Effect of PD-1 Inhibitor on PI3K/AKT Pathway in Tumor Cell and TCell Activity in Non-small Cell lung Cancer (NSCLC)
Authors: Da Siqi
Published: August 2023

Lung cancer is one of the most lethal cancers around the world and non-small cell lung cancer takes up about 85% ofthe cases. PD-1 inhibitor is an antibody used in immunotherapy to treat cancer. Previous studies have reported thatthe PD-1 inhibitor can block the PD-1/PD-L1 binding and help the immune system recognize and attack tumors. ThePI3K/AKT signaling pathway is an important target of the PD-1 downstream pathway. This paper studies the effects ofPD-1 inhibitor Pembrolizumab on the activation of the PI3K/AKT pathway in vivo. In this study, A549 cell line willbe used as the non-small cell lung cancer model. The immune-deficient mice will be injected with Keytruda, saline(negative control) or Taxol (positive control). Flow cytometry and Western Blot will be used to measure the activationof tumor cells and CD4 T cells. This paper investigates whether or not PD-1 inhibitor would effectively block thePI3K/AKT pathway and increase T cell proliferation. The result of this study will explore the blocking mechanism ofPembrolizumab on PI3K/AKT pathway. Future studies should focus on the acquired resistance caused by mutations andits effects on PD-1 inhibitor treatment with PI3K/AKT pathway activation as the biomarker.
Research on Curcumin Inhibition HepG2 Human Hepatoma Cells
Authors: Zhang Qi
Published: August 2023

In recent years, with the deepening of the understanding of cancer, it has been recognized that cancer can be preventedthrough specific diets. Numerous in vitro and in vivo experimental models have also revealed that Curcumin regulatescellular signaling pathways effects of Curcumin likely activate cell death signals and induce apoptosis in cancer cells,thereby inhibiting the progression of the disease. In this study, the impact of Curcumin on the expression level of P53protein in HepG2 human hepatoma cells was observed to explore its inhibitory effect and apoptotic induction of HepG2Iand its mechanism. In this study, the MTT method will be used to detect the effect of Curcumin on the proliferationof HepG2 human liver cancer cells, and the regression calculation of Curcumin IC50 will be conducted according tothe concentration and inhibition rate. The western blot method will be used to detect the effect of ginger and flavin onthe expression of wild-type p53 in tumor cells. The effect of Curcumin on Bax apoptosis protein expression in HepG2human hepatoma cells was detected by pFT-A, a p53 inhibitor.
The Optimal Allocation of Securities for Portfolios
Authors: Zhang Junhao
Published: August 2023

Portfolio optimization assists in the selection of the optimum portfolio to meet certain goals. The most often usedportfolio optimization model is the Markowitz Model (MM). The approach highlights the need to select assetscomplementing one another to reduce risk for investors. It compares the risks and returns of multiple equities to discoverwhich asset offers the best returns while posing the fewest hazards. To simplify the Markowitz Model, the Index Model(IM) employs a single element, the market index, which impacts all investment returns. Using the MM and IM, thisstudy analyzes permitted portfolio areas for ten stocks and one broad equity index. The ten businesses were chosenfrom various industry areas. SPX, NVDA (Technology), CSCO (Technology), INTC (Technology), The Goldman SachsGroup (Financial Services), US Bancorp (Financial Services), TD CN (Financial Services), Allstate (Financial Services),Procter & Gamble Company (Personal Care Products), Johnson & Johnson (Pharmacy), Colgate-Palmolive (PersonalCare Products).The firms from several industrial sectors are chosento guarantee the risk-diversified final portfolio. As aconsequence, the efficient portfolio employs the weightsthat yield the highest returns for a given risk level orthe lowest risk for a given projected return level whendetermined using the MM or IM. We concluded from thedata that the IM optimization model well approximatesthe MM optimization model by minimizing the number ofestimations necessary for model estimation.
Research on Key Technologies and Comprehensive ManagementStrategy of New Energy Hybrid Electric Vehicles
Authors: Liu Yipeng
Published: August 2023

New energy hybrid electric vehicles (HEVs) have emerged as a promising technology for reducing the usage offossil fuels and emissions in the transportation sector. This paper reviews the key technologies and comprehensivemanagement strategy of new energy HEVs. The key technologies of new energy HEVs include battery technology,power technology, and comprehensive management strategy. Battery technology must provide high energy density, longcycle life, and high power density, while power technology must provide high efficiency, low emissions, and smoothpower delivery. The comprehensive management strategy includes energy management control and a battery thermalmanagement system, which optimize the battery’s energy flow and temperature control. The paper discusses the basicprinciples and components of new energy HEVs and examines the developments and research in each technology.The article also explores the challenges and opportunities of new energy HEVs. It concludes that the developmentand adoption of new energy HEVs are essential for achieving a sustainable transportation system and reducing thetransportation sector’s environmental impact.
Does Panax notoginseng (Sanqi) inhibit H22 tumor growth via improving the host’s cellular immunity?
Authors: Lin Han
Published: August 2023

Ginsenoside Rg3 has many functions, including anti-tumor activity, antioxidant activity, and immune system modulatory activity. Interestingly, There are two stereoisomers exist in Rg3, 20(S)-ginsenoside Rg3 [20(S)-Rg3] and 20(R)-ginsenoside Rg3 [20(R)-Rg3], respectively. These two isomers have different pharmacological effects due to their stereospecificity. In this study, we compared their effect of stimulating the ConA to induce lymphocyte proliferation and increase the cytokines IL-2 and IFN-γ levels in mice and improve the cellular immunity of the host. The study predicted that ginsenoside (Rg3) could increase Th1-type cytokines interleukin-2 and interferon-γ and stimulate ConA-induced lymphocyte proliferation in mice, thereby improving cellular immunity in H22 mice. The effects of the Rg3 R-form were significantly greater than Rg3 S-form.
An analysis of how motivated reasoning and confirmation bias affect people to accept “true news” through social media selectively
Authors: Peng Jingshu
Published: August 2023

In recent years, with the development of technology, social media has started to appear in people’s lives, rapidly entering people’s lives along with the progress of the Internet. However, with the rise of social media, self-publishing has gradually proliferated on the Internet, with all kinds of news being sent without verification, causing much distress to people. It is, therefore, essential to understand why people selectively accept “true news” through social media. This study examines why people believe in fake news from the perspective of different “Emotional” Tendencies through a content analysis of four posts from different social media applications. The findings show that the public relies on theories related to motivated reasoning and confirmation bias when selectively accepting fake news. In particular, confirmation bias is a case where people, keen to believe in claims that are consistent with their beliefs or their lack of knowledge, are often attracted to the words and texts of the poster and unconsciously believe their story, thus contributing to their agenda. This research studies some of the main factors that have contributed to the public’s selective belief in fake news in recent years and helps to understand more about how people perceive and recognize fake news.
Deletion of the GAS Regulatory Sequence of IFN- γ Induced Gene(ICAM-1) by Using CRISPR Cas9 to Decrease the Jak3/Stat3Dependent IDO Expression to Repress Tumor Cells Development
Authors: Wu Ruoxi
Published: August 2023

IDO is a checkpoint molecule that regulates T-cell proliferation. Since IDO contributes to T cell death and creates anenvironment for cancer cells to grow, it is necessary to regulate IDO expression. Previous studies demonstrated thatIFN-gamma-induced genes would indirectly activate IDO expression through the Jak/3 pathway, and ICAM-1 is oneof the IFN-gamma-induced genes. This work investigates the effect of ICAM-1 on IDO expression and the effect of2 GAS segment knockouts on ICAM-1 expression. CRISPR-Cas9, heat shock transformation, PCR, and restrictiondigestion are used to knock out the target sequence (GAS) and insert the successful knocked-out gene into the E. coli.RT-PCR is utilized to measure the expression level of ICAM-1 and IDO after the introduction of successfully knockedout genes. The possible result of this work presents that both GAS gene knockouts are thriving; the new gene withoutGAS – 2787 bps expresses less ICAM-1 protein than the gene without GAS – 115 bps, and ICAM-1 does not affect IDOexpression at all. Results of this work indicate that the GAS sequence that is farther away from the ICAM-1 RBS sitemight decrease the ICAM-1 expression level less than does GAS sequence that is nearer to RBS, and ICAM-1 might nothave any direct impact on IDO expression, which means that tumor cell development cannot be inhibited by regulatingICAM-1 expression. Future studies could research more on functions of IFNgamma-induced genes other than ICAM-1and their relationships with IDO expression.
Artificial Intelligence: Adaptation Into Current Biomedical Engineering and Its Coefficient of Difficulty?
Authors: Ma Sichen
Published: August 2023

Artificial Intelligence (AI) is a gigantic, developing subject used comprehensively in the continuous period of Biomedical Engineering, where scientists are investigating all the purposes of artificial intelligence and contemplating how to foster it. The accuracy of AI is enhanced through daily improvement, and the current prediction using AI is evaluated by its accuracy in this literature review. The present achievement of AI in healthcare is discussed with future applications. As AI is an arising innovation, its downsides are inevitable and considered. This review summarizes the unsolved questions and difficulties clinics and engineers face individually.
Effect of the Knockout of FGL1 by CRISPR on the GefitinibSensitivity of PC9/GR Cells
Authors: Ji Yufan
Published: August 2023

This paper will investigate the effect of the Knockout of FGL1 by CRISPR on the EGFR signaling analyzed phosphorERK western blot and how it may control the gefitinib sensitivity of PC9/GR cells measured by the MTT Assay. Thisexperiment will knock out FGL1 using CRISPR. The Knockout will then be verified through Phospho-ERK westernblot. Moreover, the sensitivity of the gefitinib will be measured by the MTT Assay. The possible results generated fromthe reports’ experiments may provide insight into future clinical trials of FGL1 Knockout consequences on gefitinibsensitivity. Gefitinib is a potential drug for lung cancer. Therefore, investigating this drug may help scientists betterunderstand how the FGL1 may increase the sensitivity of Gefitinib cells and potentially discover a breakthrough to curecancer.
A study on the development of the digital economy to international trade
Authors: Hu Xinyun
Published: August 2023

Global trade, as a crucial link connecting production and consumption across different regions, plays a vital rolein the era of the digital economy. The rise of the digital economy has injected new vitality into global trade andpropelled its high-quality development. This holds significant importance and far-reaching implications for enhancingcirculation efficiency, competitiveness, establishing a unified national market, and achieving the “dual circulation” newdevelopment pattern. Therefore, this paper aims to evaluate the impact of digital economic development on the highquality development of global trade by utilizing China’s import and export volume and digital economy index from2018 to 2022 as the depende
Research on the Reform of Innovation and EntrepreneurshipEducation in Colleges and Universities Based on the Perspective of“Double Creation” Strategy
Authors: Li Jintu
Published: August 2023

In this paper, we explored the reform of innovative and entrepreneurial education in universities under the “DoubleInnovation” strategy. The strategy, proposed by the Chinese government, encourages “mass entrepreneurship andinnovation” and has significant implications for tertiary education. The research underscores the necessity forintegrating entrepreneurship education into the general curriculum, promoting interdisciplinary learning, and developingindustry partnerships. It evaluates the current situation, identifies existing challenges, and suggests possible solutions foreffectively implementing this strategy in higher education. Through a combination of theoretical and empirical research,the paper proposes a framework for systematically incorporating the “Double Innovation” strategy into the universityeducation system.
Tumor Suppressor Gene VHL, Mechanism and Related Therapy
Authors: Shi Dongrui
Published: August 2023

Von Hippel-Lindau (VHL) syndrome is a rare hereditary disorder characterized by the development of multiple tumorsin various organs. This paper provides a comprehensive overview of the VHL gene, its mechanism of action, and itsimplications in VHL-related tumorigenesis. The first section explores the role of the VHL tumor suppressor gene inregulating angiogenesis and oxygen sensing, highlighting its significance in tumor suppression. The second sectiondiscusses the association between VHL gene mutations and the development of various tumor types, emphasizing thediverse clinical manifestations of VHL syndrome. The third section examines the diagnostic methods for identifyingVHL gene mutations, including genetic testing and clinical evaluations. The fourth section delves into therapeuticapproaches for managing VHL-related tumors, encompassing surgical interventions, targeted therapies, radiotherapy,and emerging treatment strategies. This paper aims to enhance understanding of VHL syndrome, facilitate earlydiagnosis, and guide treatment decisions for individuals affected by this complex disorder.
Enhanced mTORC1 Pathway Leads to Melanocyte Stem Cell AgingThrough DNA Damage
Authors: Duan Yucheng , Lyu Mingze , Wu Chengxuan , Xu Duan
Published: August 2023

The aging of skin stem cells is always attractive and highly relevant to our daily lives. Hair graying, mainly caused bymelanocyte stem cell (MeSC) aging, is a severe problem for many people. Previous studies have pointed out that DNAdamage is a significant reason for MeSC aging, and the enhanced mTORC1 pathway leads to DNA damage. Here,experiments in vivo and in vitro were designed to verify that enhanced mTORC1 pathway leads to melanocyte stemcell aging through the cause of DNA damage. The research could have the significance of discovering possible reasonsfor hair graying and providing some new ideas in treating this abnormal divergence and other diseases relevant to cellaging.
Unveiling an Aloof Democracy: Voting Apathy in 21st Century Japan
Authors: Yang Mingxuan
Published: August 2023

On April 10, 1946, when Japan held its first general election after the devastating World War II, 72.08 percent of eligible voters of the country that failed into the debris of war went out to cast their ballot (Nohlen et al., 2001). Since then, along with Japan's postwar development and prosperity, in the next 18 general elections until 1993, the turnout maintained high stably at around 70 to 75 percent. However, after the millennium's coming, the Japanese participatory attitude towards elections seemed to come to a changing point. The turnout in subsequent elections declined noticeably and then stagnated at lower than 60 percent, which was unmatchable with the late 20th century's level (Nohlen et al., 2001). Even worse, the turnout of the previous three consecutive elections became the lowest three in the contemporary Japanese history of democracy (Tomoko, 2021). Much academic literature interprets the drastic drop and continuous low turnout as a typical sign of growing voter apathy, which means the constituents lack interest and motivation to vote when elections come (Shade & Teruelle, 2014).
But why are there so many Japanese voters who lost interest in voting in recent elections? What is the cause of the growing “voting apathy,” and what could it mean to Japanese democracy and political development? Several factors could play critical roles, and they may compound and reinforce the effect of one another. The new electoral system could discourage some people from voting as it is institutionally disadvantageous to small parties and detrimental to political pluralism. The effect of institutional factors was amplified by the weakness of opposition parties from ideology to organization and internal unity, which then left voters with fewer feasible choices in elections. The increasing political alienation of young people should also be taken into account, as the drop in their turnout is the most significant in all age groups. Finally, the Japanese government, mostly led by the conservative Liberal Democratic Party (LDP), could be likely to benefit from the status quo and therefore is reluctant to reform and actively encourage electoral participation.
Data-Driven Approach to Understanding the Role of Short Videos inEnglish Vocabulary Learning
Authors: Chen Ruohan
Published: August 2023

Through a data-driven approach, we scrutinize the role of short videos in English vocabulary learning. Leveragingbig data from various online learning platforms, we conduct a rigorous quantitative and qualitative analysis. Findingsdemonstrate a notable impact of short videos on vocabulary enhancement, significantly facilitated by this format’sinteractive and engaging nature. Employing data points such as user interaction, retention rates, and real-life applicationof new vocabulary, we establish compelling correlations between these factors and the use of short videos. Weunderscore the potency of visual and auditory stimuli in short videos, offering a comprehensive learning experiencesurpassing traditional methods. We illustrate that short videos can break down language, age, and geographical barriers,thereby universalizing access to English language learning. However, we identify the design quality of the video, learnermotivation, and the pedagogical context as pivotal factors influencing the effectiveness of short videos. Data suggests acall for further research into these areas to optimize the efficacy of short videos in vocabulary learning. Our study thusdelivers a data-driven narrative on the pivotal role of short videos in English vocabulary learning, potentially guidingthe design of future language learning interventions.
A Comparative Analysis of Chinese Traditional Educational Thoughtand Western Educational Thought-- Taking Chinese High School Education as an Example
Authors: Qian Chunyu
Published: August 2023

The education transformation and pattern have been enriched by global modernization. It generally promotes and bringsopportunities to the strategies and practice of internalizing education. Meanwhile, it improves the school’s runninglevel of international education. These are the intrinsic needs for the development of education and the inevitablerequirements of the development of the times. There are advocates of Western educational concepts who hold blindpursuits. Every education mode has imperfections; some aspects are usually sacrificed based on the background theory.This essay has comprehensively reviewed the educational thoughts and pedagogy of student learning in China. It hasdiscussed the theoretical background of Chinese and Western educational thoughts and the features, development,advantages, and disadvantages of Chinese high school education and international high school education in China. Bycomparing these two types of high school education evaluation systems, teaching system, and curriculum system, itcan be seen that they reflect different educational thoughts, which have their strengths and weaknesses. Based on theanalysis, it is significant to discover that two education systems can learn from each other to create a more effectivelearning environment. Ultimately, it is hoped that this study could give possible solutions and prospects for the future ofChinese high school education.
The Application of mRNA in Treating Cancer
Authors: Wang Yi
Published: August 2023

Messenger ribonucleic acid (mRNA) immunity and polypeptides, chimeric antigen receptor T cells (CAR T),deoxyribonucleic acid (DNA) immunity. These drugs have the advantages of simple preparation, low cost, low toxicity,and high biosafety in cancer immunotherapy. It is an up-and-coming drug candidate for tumor treatment. At present,many enterprises have the production technology of mRNA vaccines. International pharmaceutical enterprises formRNA immunotherapy of cancer are in clinical research and have shown good immune effects in clinical practice.