bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh penanaman modal dalam negeri (PMDN), penanaman modal asing (PMA), ekspor dan impor terhadap pertumbuhan ekonomi Provinsi Jambi
Authors: Ningsih Dian Setia , Haryadi Haryadi , Hodijah Siti
Published: February 2021

This study aims to analyze the development of PMDN, PMA, Exports, Imports, and Economic Growth in Jambi province and to analyze the influence of PMDN, PMA, Exports, and Imports on economic growth in Jambi province. The analysis model used is the Autoregressive Distributed Lag (ARDL). The results showed that in the short term PMDN had a significant negative effect on economic growth. PMA has a positive and significant effect on economic growth. Exports have a significant positive effect on economic growth. In the long term, PMDN has a positive and significant effect on economic growth. PMA has a negative and significant effect on economic growth. The export variable has a positive and significant effect on economic growth. And imports have a positive but insignificant effect on economic growth. It is hoped that economic growth will continue to increase from year to year, so the government must play an important role in increasing economic activities that have existing potentials so that the people's income is high which also reduces poverty and inequality that occurs.
Runoff data series prediction based on Complete Ensemble Empirical Mode Decomposition with Adaptive Noise and Radial Basis Function Neural Network extension
Authors: Zhang Jinping , Jin Youlai , Xiao Honglin
Published: February 2021

This study investigated the influence of data extension on the
decomposition and prediction accuracy of runoff data series. To this
end, an original data series was constructed using annual runoff data
from a hydrological station in China (Tang Naihai) for the period
1956–2013, and radial basis function neural network (RBFNN) extension
was applied to the original data series. Complete ensemble empirical
mode decomposition with adaptive noise (CEEMDAN) was then applied to
both data series, and their decomposition and prediction results were
compared. The decomposition results indicate that the end effect
significantly lowers the accuracy of low–middle frequency components.
Nevertheless, the end effect could be effectively suppressed and
decomposition error could be reduced by applying RBFNN extension. At the
end points, the extension data series could more accurately reflect the
real fluctuation characteristics of components and subsequent variation
trends. Regarding component prediction, the prediction results followed
the variation trend of the components themselves, with a rather large
gap in the prediction results of low-frequency components between the
two groups of data series. The final prediction results obtained from
the reconstruction of the component prediction results suggest that the
extension sequence has a clearly superior prediction accuracy than the
original data series. Hence, when using the CEEMDAN method to process
non-stationary hydrological data, multi-time-scale information of the
data series can be obtained through reasonable extension after
decomposition of the original data series. The acquired information
provides evidence for the analysis and prediction of the evolution law
of hydrological elements.
Detection and genetic characterization of porcine sapovirus from pigs with diarrhea
Authors: Shen Huigang , Zhang Jianfeng , Gauger Phillip , Burrough Eric , Zhang Jianqiang , Harmon Karen , Wang Leyi , Zheng Ying , Petznick Thomas , Li Ganwu
Published: February 2021

Porcine Sapovirus (SaV) was first identified by electron microscopy in
the United States in 1980 and has since been reported from both
asymptomatic and diarrheic pigs usually in mixed infection with other
enteric pathogens. SaV as the sole etiological agent of diarrhea in
naturally infected pigs has not previously been reported in the United
States. Here, we used four independent lines of evidence including
metagenomics analysis, real-time RT-PCR (rRT-PCR), histopathology, and
in situ hybridization to confirm porcine SaV genogroup III (GIII) as the
sole cause of enteritis and diarrhea in pigs. A highly sensitive and
specific rRT-PCR was established to detect porcine SaV GIII. Examination
of 184 fecal samples from the outbreak farm showed that pigs with
clinical diarrhea had significantly lower Ct values (15.9 ± 0.59)
compared to clinically unaffected pigs (35.8 ± 0.71). Further survey of
336 fecal samples from different states in the United States
demonstrated that samples from pigs with clinical diarrhea had a
comparable positive rate (45.3%) with those from non-clinical pigs
(43.1%). However, the SaV-positive pigs with clinical diarrhea had
significantly higher viral loads (Ct = 26.0 ± 0.5) than those positive
but clinically healthy pigs (Ct = 33.2 ± 0.9). Phylogenetic analysis of
20 field SaVs revealed that all belonged to SaV GIII and recombination
analysis indicated that intra-genogroup recombination occurred within
the field isolates of SaV GIII. These results suggest that porcine SaV
GIII plays an important etiologic role in swine enteritis and diarrhea
and rRT-PCR is a reliable method to detect porcine SaV. Our findings
provide significant insights to better understand the epidemiology and
pathogenicity of porcine SaV.
Arabidopsis ADF7 inhibits VLN1 to regulate actin filament dynamics and ROS accumulation in root hair development responses to osmotic stress
Authors: Wang Che , Bi Shuangtian , Liu Caiyuan , Li Mingyang , Liu Xiaoyu , Cheng Jianing , Wang Lu , Lv Yanling , He Ming
Published: February 2021

Actin dynamics are essential for root hair development, however, the
underlying molecular mechanisms of actin binding protein cooperation and
plant abiotic stress responses are largely unknown. Here, genetic
analysis displayed that actin depolymerizing protein ADF7 and actin
bundling protein VLN1 are positively and negatively involved in root
hair development in Arabidopsis, respectively. Moreover, ADF7 acts
upstream of VLN1 in root hair development by the analysis of RT-qPCR,
Gus staining, Western blot and genetics. The observation of F-actin
dynamics shows that ADF7 inhibits VLN1, leading to the decline of
filament actin (F-actin) bundling and thick bundle formation and the
increase of F-actin turnover and depolymerization in epidermal cells of
root apices. Actin pharmacological experiments confirm that ADF7 and
VLN1 are via regulating F-actin dynamics to active root hair
development. Furthermore, F-actin depolymerization coregulated by ADF7
and VLN1 elevates the reactive oxygen species (ROS) level in root tips.
Additionally, F-actin depolymerization and ROS accumulation coregulated
by ADF7 and VLN1 are involved in osmotic stress-induced root hair
development. Our work reveals that ADF7 inhibits VLN1 to induce F-actin
turnover and depolymerization and ROS level in root tips, which play an
important role in root hair formation responses to osmotic stress .
The Home Accident Cases Applying to The Pediatric Emergency Department during the Covid-19 Pandemic: What Did the Pandemic Change?
Authors: Güleryüz Okşan , Colak Ozlem , Güneysu Songul Tomar , FİDANCI İlknur
Published: February 2021

Background: Whether the pandemic caused an increase in the number of
home accidents (HA) admitted to the pediatric emergency department (PED)
was investigated. Applications in a similar quarter in 2019 and 2020
were compared. Methods: The study was retrospective. Their demographic
data, the reason for admission to the hospital, the time of admission,
the length of hospital stay, intensive care rate, and interventional
procedures were recorded. The two groups were compared to find whether
there was any difference. Results: There were 700 and 597 admissions for
specified reasons during the specified period in 2019 and 2020,
respectively. In 2019, 9.46% of all cases admitted to the PED were HA
whereas the rate was 24.43% in 2020. The male/female ratios were
similar (p=0.520). The median age in 2020 (36 months) was significantly
higher than that in 2019 (33 months) (p=0.010). The main clinical
presentations also differed significantly. The incidence of falls, the
gastric/intestinal foreign bodies, and the penetrating stab injuries
were significantly higher in those in 2020 (p<0.001).
Significant differences were also found regarding diagnostic and
therapeutic interventions. During the specified period in 2019, 623
patients (89.5%) were discharged from the PED. The rate of discharge in
2020 (84.9%) was significantly lower. Also, there were significantly
more hospitalizations in other wards in 2020 than those in 2019 (3.7%
vs. 1.0%) (p=0.004). Conclusion: The Covid-19 pandemic caused an
increase in the number of HAs cases admitted to the PED relative to all
hospital admissions. The most common type of accident was falls, as in
the non-pandemic period. The pandemic caused delays in accessing
healthcare services, especially for critically ill patients, more
frequent hospitalizations, and a decrease in the rate of discharge from
the PED.
A rare cause of cyanosis: Congenital methemoglobinemia
Authors: GUEDRI RAHMA , Missaoui Nada , ESSADDAM Leila , Becher SAAYDA Ben
Published: February 2021

A 13-month-old infant, born from a consanguineous marriage. She
presented isolated cyanosis. Physical examination was normal. Pulsed
oxygen saturation was 94% in room air. Methemoglobin level was 39.4%.
The diagnosis of congenital methemoglobinemia type I was retained. She
was successfully treated with methylene blue infusions and ascobic acid.
The Pharmacokinetics of Ketamine in the Breast Milk of Lactating Women: Quantification of ketamine and metabolites
Authors: Wolfson Philip , Cole Rob , Lynch Kara , Yun Cassandra , Wallach Jason , Andries Julane , Whippo Melissa
Published: February 2021

Abstract: There is no available data on the secretion and concentration
of ketamine and its metabolites in breastmilk. There are statements in
the literature made as to the safety of the use of ketamine in lactating
women, though these are unsupported. This information is pertinent for
the treatment of breastfeeding women who may have depression, PTSD,
postpartum depression, and other emotional difficulties and would
benefit from ketamine treatment. The objective of this study was to
measure the presence and concentration of ketamine in breastmilk and
three of its metabolites. We have provided a longitudinal
pharmacokinetic analysis of the presence of ketamine and several of its
major metabolites (norketamne, dehydronorketamine and hydronorketamine)
in 4 women receiving 2 different intramuscular doses of
ketamine—0.5mg/kg and 1.0mg/kg. Our results demonstrate the
insignificance of ketamine’s presence In breast milk after a 12-hour
period of suspension. Given ketamine’s proven record of effectiveness
for the treatment of depression, and its intermittent use for this
purpose, our data support the safety of its administration for the
treatment of postpartum depression (PPD)and other emotional disorders
during a woman’s chosen period to provide breast milk to her child
without significant interruption or exposure. This provides the
necessary data for the study of ketamine assisted psychotherapy as a
potential treatment of postpartum emotional disorders without the loss
of the relationship between mother and child which breast feeding so
vitally provides. We review conventional pharmacologic treatments
involved in the treatment of PPD.
Дистанционная проверка знаний требований охраны труда у работников компании с использованием современных систем идентификации и аутентификации личности
Authors: Сенченко Владимир
Published: February 2021

Данная работа посвящена обоснованию и расчету экономической эффективности дистанционной проверки знаний требований охраны труда. В данной работе предложены концептуальные проектные решения по реализации данной работы на практике. В работе предложено подписывать документы при проведении инструктажей и проверке знаний требований охраны труда (протоколы, журналы, удостоверения) при помощи электронной подписи. Для членов комиссий по проверке знаний требований охраны труда предложено выпустить квалифицированные электронно-цифровые подписи. Для инструктируемых и экзаменуемых работников предлагается использовать простую электронную подпись: при приеме на работу заключать с работником соглашение об использовании электронной подписи; интегрировать в модуль ЕСЭД систему идентификации и аутентификации личности при помощи СМС (за аналог взята модель дистанционного банковского обслуживания СбербанкОнлайн).

В работе приведены образцы документов для практической реализации проекта применительно к существующей системе электронного документооборота в ПАО «Ростелеком». В приложении приведена позиция органов надзора по вопросу законности дистанционного метода.

Расчет финансовой модели проекта показал NPV 85+ млн. рублей при первоначальных инвестициях 5 млн. руб. Данный экономический эффект реализуется только при реализации данного проекта в масштабах всей компании ПАО «Ростелеком», так как требует внесение изменений в корпоративную систему электронного документооборота.

Задачи, которые решались в ходе работы: 1) Составить карту эмпатии при проведении проверки знаний требований охраны труда в техническом подразделении; 2) Построить карту потока ценности при проведении про-верки знаний требований охраны труда. Определить муда; 3) Предложить пути по устранения муда. Выработать концептуальные проектные решения по реализации практике; 4) Изучить и проанализировать ключевых стейкхолдеров при реализации проекта дистанционной проверки знаний; 5) Изучить инструменты и методы проектного управления применительно к данному проекту; 6) Спрогнозировать структуру команды по реализации данного проекта; 7) Оценить риски проекта; 8) Составить финансовую модель при реализации проекта. Сделать расчет NPV; 9) Изучить и описать конфликт парадигм мышления профессионального сообщества при цифровизации процесса проведении проверки знаний требований охраны труда; 10) Сделать оценку предложенного проектного решения.

В заключительной части дана оценка практической ценности и экономической эффективности данного проекта применительно к компании ПАО «Ростелеком».

Данная работа составлена из выполненных домашних заданий в рамках программы iMBA. В работе приняты ряд допущений, которые требуют более глубокой проработки профильными специалистами со знанием цифровых технологиях.
Inovasi Instrumen Biola Berfret di MTS Nurhasanah Kabupaten Batubara
Authors: Fauzi Ade , Widiastuti Uyuni
Published: February 2021

Tujuan Penelitian ini 1) Untuk mengetahui proses pembelajaran biola menggunakan inovasi instrumen biola berfret di MTs Nurhasanah Kabupaten Batubara, 2) Untuk mengetahui proses pembuatan Inovasi Instrumen biola berfret. Teori yang digunakan adalah teori inovasi, teori pembelajaran, teori biola, dan fret (pembatas nada). Teknik pengumpulan data melalui observasi, wawancara, dan dokumentasi. Hasil penelitian ini menunjukkan 1) Proses pembelajaran biola mencakup penjelasan mengenai bagian-bagian biola beserta fungsinya diikuti dengan membaca notasi musik dengan tabulasi angka serta materi ajar dari buku panduan metode Suzuki. 2) Proses pembuatan instrumen biola berfret terdiri dari beberapa tahapan antara lain: (1) proses pembuatan, (2) langkah-langkah pembuatan, (3) material yang digunakan, dan (4) kelebihan serta kekurangan instrumen biola berfret. Proses pembuatan cukup sederhana hanya menambahkan fret yang ditanam pada fingerboard kemudian diukur dengan alat ukur cromatic tuner
International relations: discourse and dissonance of LGBT perception
Authors: Botasheva Asiyat
Published: February 2021

International relations shape the image of the modern world and its structure, which at this stage is sometimes characterized by very unique networks of human relationships, a variety of features of the development of peoples. In this regard, the attitude of international organizations towards sexual minorities, organizations that participate in the recognition or denial of gays and lesbians, and same-sex married couples is very remarkable. This review study proves that there is some dissonance in international relations caused by the fact that not all international organizations and States respond equally to the Declaration of the rights of representatives of sexual minorities that protect the institution of LGBT and same-sex marriage.
Features of the adaptation of internally displaced persons to the new social environment
Authors: Tagiyeva Tarlan
Published: February 2021

The issues of adaptation to a new environment have always been relevant, today they are also important, since in the context of globalization people are "eternal nomads" (Attali) looking for a better life. Along with this, the concept of "forced migrants" has long been included in the scientific circulation, as a category of people, for various reasons forcibly or for reasons beyond their control, who left their habitable places. The adaptation of internally displaced persons who have become victims of military conflicts is especially painful, since the state, as a rule, is not able to provide them with timely and necessary assistance. There are peculiarities of communication between the settlers and the local population, which should be taken into account in the matter of psychological rehabilitation and subsequent social adaptation.
Problems of variability of the musical genre reng in the mugham performing arts of youth
Authors: Ildyrymly Fidan
Published: February 2021

Consideration of the variability of the musical genre of rang in mugam performing arts showed that ranks arose and developed in the art of mugam as a form of vocal-instrumental music. Their melodic structure is directly related to the sections of mugam. There are numerous varieties of this relationship. Based on the analysis of the musical notation of the ranks, it was determined that in practice of performing mugam the ranks are directly related to the vocal-instrumental mugam, and this is especially important for their compositional structure. In this regard, in almost every version of mugham destgahs there is a set of different ranks, including tesnifs. The analysis of various musical records of the ranks in the musical performing arts helps to identify the features of the manifestation of this form of folk music in mugam, as well as the further development of this musical genre and musical culture as a whole. We consider it appropriate to study, primarily, the vocal-instrumental interpretation of mugham when studying mugam destgyahs and the melodic interconnections of rangs and tesnifs with sections (shobe) of mugam. After analyzing various musical notations of mugam dastgahs, we were able to trace how rengi relate to mugam shobe. It can be noted that many rengi are used in the recordings of these works associated with various performances in relation to various shobe of mugams. This feature is inherent in various mugham dastgahs – "Shur", "Segah", "Chahargah", "Bayati-Shiraz", "Shushter", "Humayun", etc. All this can be traced in musical notations, as well as in live mugham singing and sound recordings, which helps to determine the numerous variants of rengs related to these mugams. Within the framework of each mugham, dozens of rengs were created and included in musical practice. Part of this rich musical heritage is captured and preserved in sound recordings and sheet music. We believe that it is advisable to study rengi, grouping them into mugham families in order to analyze their musical language and reveal their inherent variability.
Evolution of bayan performance in historical retrospective: from improvisation to academization
Authors: Grigoriev Anatoly
Published: February 2021

The article traces the evolution of button accordion performance in interaction with constructive changes in instrumentation and the repertoire approach to performance. In order to identify a holistic picture of the evolution of button accordion performance, a scientific review of this issue in a historical retrospective is carried out: a historiographic review of the history of the creation and development of the button accordion, the tendencies of compositional creativity in the development of the button accordion repertoire.
To the history of tolerance formation as an integral element of the modern way of life
Authors: Mehdieva Madina
Published: February 2021

Tolerance has been the most important moral characteristic and social value of a person since the inception of human society. Tolerance, which is defined as a spiritual phenomenon, manifests itself in various forms in all areas of life and determines the nature of communication in human behavior. Among them we can show everything, from the most primitive ancient forms of consciousness to forms of artistic and rational thinking. The essence of each of these forms of self-expression is mutual understanding, understanding and empathy. As human knowledge deepened, thoughts and ideas around this problem expanded. The history of the development of tolerance shows that today this moral and legal category is an integral part of the modern way of life.
Foreign experience in reducing the construction time
Authors: Salnikov Konstantin Evgenevich
Published: February 2021

The subject of this research is administrative relations that arise in the process of reducing the construction time as a branch of material production that is carrying out erection of buildings and reconstruction of structures of various designation. The object of this research is the construction complex as a whole; companies of various corporate structure functioning on the investment-construction sector; organizational legal forms of interaction between the parties to the investment-construction process; state regulation in the sphere of major construction. The goal of this article consists in examination of foreign experience in resolution of primary issues with regards to construction time management: assessment of the duration of processes and allocation of resources. The author explores such aspects of the topic as the economic component of administrative impact upon the implementation of a construction project; parameters of project management (time, quality, and cost); modern time management techniques; business process reengineering; principles of cross-team building. The scientific novelty is defined by the insufficient study of the questions of improvement, theoretical, experimental and feasibility study of technological processes, methods and forms of construction planning and its production facilities in the context of reducing the construction time. The value of this work for the national economy consists in studying the theory and practice of reducing the construction time and searching for solutions of scientific and technical problems of construction by means of development and creation of the competitive construction technologies, as well as organizational and technological decisions. The following results were achieved: determination of the key parameters of project management (time, quality, and cost); analysis of cost increase of the project depending on usage of the strategies for reducing production schedule; examination and visualization of development strategies for increasing competitiveness of the companies in complex business, as well as assessment of the level of customer satisfaction according to the system of basic criteria. The author passes an original opinion on the effectiveness of time reduction techniques.
Securitization as a method of managing the liquidity of a commercial bank
Authors: Sidorov Aleksandr Andreevich
Published: February 2021

The financial system of the Russian Federation is currently facing deterioration of the conditions of external business environment. The spread of the coronavirus infection COVID-19 turned 2020 into the most difficult year for development of banking system of the Russian Federation. This article is dedicated to the research analysis of practical role of securitization as a mechanism and method used in management of the internal liquidity of a commercial bank. The relevance of this study is substantiated by the need to improve the mechanisms of financial risk management, which emerge in activity of credit institutions that experience a shortfall of internal liquidity of the assets. Methodological framework is comprised of the general scientific methods of cognition of economic phenomena, which allowed viewing the relevant tools of managing the liquidity of commercial banks and indicating most topical issues and barriers. The research is based on the combination of normative and positive analysis, principles of uniformity of historical and logical, as well as analytical approach towards studying the economic phenomena that reflect the contradictory nature of social processes. The article examines the relevant problems of formation of the internal liquidity of banking sector of the Russian Federation; as well as theoretical aspects of the concept of “liquidity” of a commercial bank. Description Is given to the mechanism of managing the liquidity of a commercial bank. The author considers the fundamentals and characteristic of securitization as a method of managing liquidity of a bank, and lists the advantages of using securitization in ensuring internal liquidity of banking activity. The benefits of securitization as a method of managing the liquidity of commercial banks in the Russian Federation are analyzed.
Features of managing Large Bridge Construction projects in China
Authors: Liu Youren , Zub Anatoly Timofeyevich
Published: February 2021

Using the methods of document research and comparative analysis, the author examines in detail such aspects of the topic as the role of the state in the management of large construction projects, a three-dimensional model of integrated management of large bridge projects, the impact of fine management on improving the quality of the project, the function of "cultural management", etc. Special attention is paid to the management of bridge construction projects between the river and by sea is a large-scale, complex and integrated management of engineering projects, representing the characteristics of interdisciplinary, multi-domain and multi-regional cross-penetration, reflecting the rich connotation of overall planning, coordination and integration of resources. Based on the analysis of the Sutong Bridge, the bridge over the Hanzhouwan Bay, the Jiangyin Bridge, this article summarizes the feature of construction project management in China. В  The main conclusions of the study are the mechanism of the state's influence on the management processes of large construction projects that ensure great success of megaprojects. In the course of modernization, China has formed a set of management characteristics of large-scale engineering bridge construction with Chinese features thanks to a large amount of research and practice. With the support of the country as a basis, a management system combining industrial management and engineering construction management, national power and business. The mutual influence of the authorities, the combination of cultural management and emotional management through a "refined" transformation of management comprehensively guarantee the successful completion of the construction of super-large bridge projects. It provides background information for managing other large-scale engineering projects. The construction of large-scale projects laid the foundation for China's socio-economic development.
Avaliação do consumo alimentar e associação com o diagnóstico clínico e fatores de risco em pacientes cardiopatas
Authors: Moura Alissa Raquel Amoras , Nogueira Rodrigo Tavares , De Vasconcelos Fábio Costa , Da Silva Paloma Barbosa , Da Silva Cybelle Barbosa Pires , Barroso Ana Cândida de Souza , Barros Jamile Cristine Marques
Published: February 2021

Objetivo: Avaliar o consumo alimentar e associá-lo ao diagnóstico clínico e fatores de risco de pacientes cardiopatas. Métodos: Estudo do tipo descritivo, transversal e inferencial, desenvolvido com 32 indivíduos adultos e idosos, de 23 a 88 anos, em um hospital público de Belém do Pará. Aplicou-se um questionário sobre fatores de riscos relacionados às doenças cardiovasculares e outro de frequência alimentar do tipo MEDFICTS. Resultados: Verificou-se uma predominância do sexo masculino (84,38%) e idade entre 49 a 61 anos (37,50%). Diagnosticou-se mais frequentemente a Insuficiência cardíaca congestiva (ICC) associada ao infarto agudo do miocárdio (IAM). Observou-se que os principais fatores de risco foram: tabagismo, etilismo, alto consumo de carne vermelha, baixo consumo de frutas e estresse antes do diagnóstico. Cerca de 37,5% dos pacientes precisavam fazer alguma mudança dietética, sendo tal alteração associada ao diagnóstico de IAM/ICC (91.46) e aterosclerose (84.46). O alto consumo de carne vermelha também prevaleceu em pacientes com diagnóstico de IAM-ICC (89,47). Conclusão: Identificou-se um percentual considerável de inadequação do consumo alimentar entre os participantes, sendo tal ingestão associada ao diagnóstico de IAM, ICC e aterosclerose, assim como a prevalência de um alto consumo de carne vermelha em pacientes com diagnóstico de IAM-ICC.
La interacción entre los derechos de propiedad intelectual y los procesos de innovación abierta aplicados en el mejoramiento vegetal moderno
Authors: Rapela Miguel A.
Published: February 2021

The knowledge requirements and the need to generate new inventions in both products and processes of modern plant breeding are highly demanding and on the frontiers of science. There is no self-sufficient technological capacity in the public or private sector capable of completely dominating such undertakings. In this general framework, the processes of open innovation, both public/private, public/public and private/private, are key to success.Despite the opportunities generated by open innovation processes applied to modern plant bre-eding, an increase in the innovation rate is not detected, as measured by the average increase in crop productivity. One possible explanation for this fact is that the genetic basis on which mo-dern plant breeding is being supported has been significantly narrowed by a lack of utilization or underutilization of genetic resources.Intellectual property rights are part of the variables of this complex equation and their applica-tion leads to three hypotheses that were tested against four real cases of open innovation applied in modern plant breeding in Argentina.In no case it was observed that the suppression of intellectual property rights has been considered a tool to promote innovation (hypothesis #1). On the contrary, what was observed is that the innovation was oriented towards those products or processes capable of being managed in an innovative way by some current intellectual property system, although protection is limited by the speed of technological advance. An alternative solution (hypothesis #3), is that the legal fra-mework to promote development should be reformulated in an integral way to adapt it to the de-velopments of modern plant breeding under open innovation processes. The decision for one or the other alternative is critical since the innovation rate resulting from the crops will depend on it.
¿Autoría algorítmica? Consideraciones sobre la autoría de las obras generadas por inteligencia artificial
Authors: Vásquez Leal Luis
Published: February 2021

Technological advances in artificial intelligence are making rethinking the current system of co-pyright protection. The present research work seeks to carry out an approach to the analysis on who owns the copyright works generated by artificial intelligence. It is discussed whether current legislation allows the so-called algorithmic authorship and the different scenarios involved in determining authorship are evaluated on this type of works. It is debated whether the authorship rests with the programmer, the system user or the person commissioning the work. It is conclu-ded that there is currently no express legal solution and therefore, a regulation must be sought according to the new technological challenges based on the consensus of the different actors that make life in the world of intellectual property.
Comparative efficiency of continuous intensity trainings and interval loads in patients aftering myocardial infarct with a subsequent corrective coronary intervention
Authors: Chistyakova Yulia V. , Mishina Irina E. , Arkhipova Svetlana L. , Dovgalyuk Yuri V. , Fokicheva Svetlana O. , Zolotareva Anna A.
Published: February 2021

Aim. The purpose of the study is to conduct a comparative analysis of the effectiveness of physical aerobic training in the mode of interval and constant loads in patients who have had a myocardial infarction with subsequent percutaneous coronary intervention. Materials and methods. 35 patients aged from 46 to 67 years old were examined in the process of passing a 3-week course of physical rehabilitation in a day hospital. Of these, 18 people (group 1) performed daily training on cardiovascular machines in the mode of interval loads, 17 people (group 2) - in the mode of moderate loads with constant intensity. Results. When conducting physical training in different training regimens, both groups of patients showed an improvement in exercise tolerance. At the same time, the interval training as compared to the constant intensity training provided a more pronounced training effect on the cardiorespiratory system due to high-intensity loading phases and at the same time a low level of hemodynamic load due to the presence of relatively low-intensity phases. Conclusion. Interval training is preferred in patients who have had a myocardial infarction followed by percutaneous coronary intervention, due to their high efficacy and safety.
Cardiopulmonary relationships in patients with concomitant chronic obstructive pulmonary disease who were hospitalized for acute coronary syndrome
Authors: Iskenderov Bahram H. , Berenshtein Natalya V. , Lokhina Tatyana V. , Ivanchukova Marina G.
Published: February 2021

Aim. To study cardiopulmonary relationships in patients hospitalized for acute coronary syndrome with concomitant chronic obstructive pulmonary disease (COPD). Materials and methods. Based on having/not having of COPD exacerbation on admission. 52 patients (29 men and 23 women) were divided into 2 groups: group 1 (n=33) with COPD exacerbation and group 2 (n=19) without COPD exacerbation. Patients examination inclused spirometry with bronchodilator test and identification of serum troponin T (TnT) levels. Results. In 30 patients TnT levels confirmed a development of acute myocardial infarction (AMI) and in 22 patients TnT levels were below the diagnostic threshold. In patients with AMI mild-to-moderate COPD was prevalent (70.0% out of all cases) and exacerbation of COPD was diagnosed in 76.7% of patients on admission. TnT levels in patients with both AMI and an exacerbation of COPD were significantly higher compared to those in patients without COPD exacerbation: 0.78±0.17 and 0.59±0.14 ng/ml, respectively (p=0.014). Patients without AMI and with COPD exacerbation had higher TnT levels compared to patients without COPD exacerbation: 0.19±0.08 and 0.11±0.04 ng/ml respectively (p=0.002). Conclusion. Thus concomitant COPD, especially with acute exacerbation, is associated with an increased risk of AMI in patients hospitalized with acute coronary syndrome.
The study of vascular wall stiffness in patients with arterial hypertension depending on some factors of risk and associated clinical conditions
Authors: Khaisheva Larisa A. , Shlyk Sergey V. , Samakaev Azat S. , Glova Svetlana E. , Pirozhenko Anna A. , Samokhina Liudmila Yu.
Published: February 2021

Aim. To study the effect of gender, age, duration of disease and different forms of ischemic heart disease on the stiffness of the vascular wall in patients with arterial hypertension by determining the propagation velocity of the pulse wave. Materials and methods. In order to study the propagation velocity of the pulse wave it was examined 369 patients with the method of volumetric sphygmography. In all patients was diagnosed arterial hypertension I-III stage, 1-3 degree, besides 47 patients were diagnosed with stable angina I-III functional class, 50 patients had a history of prior myocardial infarction. The investigation was held with the help of hardware complex "Poli-Spektr" made by Neirosoft firm (city Ivanovo) by the classical method of determining the propagation velocity of the pulse wave using synchronous registration sphygmograms of the carotid, radial and femoral arteries. Results. Patients with arterial hypertension had statistically higher velocity of pulse wave propagation for elastic-type vessels in comparison with healthy volunteers (9.48±0.18 и 7.28±0.64 cm/sec; р
Chronic renal disease in patients with type 2 diabetes mellitus
Authors: Khachaturian Nane E.
Published: February 2021

Diabetes mellitus (DM) type 2 (type 2 diabetes) is one of the most common non-infectious diseases worldwide. Chronic hyperglycemia is a leading factor in a development of vascular complications of diabetes which involve various organs, particularly the eyes, kidney, cardiovascular system and nervous system. One of the most common complications of DM is diabetic nephropathy. Presence of chronic renal disease in a patient with DM limits options of glucose-lowering therapy. Dipeptidyl peptidase-4 inhibitors are currently among medications of choice for glucose-lowering therapy in patients with chronic renal disease. All currently available dipeptidyl peptidase-4 inhibitors can be administrated to patients with end-stage kidney disease on dialysis, and a rate of their use is continuously increasing. Given a high risk of hypoglycemic conditions in patients with chronic renal disease, a regular self-monitoring of glycemia is an essential component of a treatment. Glucometer Contour Plus One is one of the most recent devices developed for self-monitoring of blood glucose. Its advantage over all other blood glucose meters is an ability to synchronize with a mobile application Contour™ Diabetes (Contour Diabetes).
Comparative pharmacoepidemiological assessment of antianginal, antiplatelet and lipid-lowering drugs in patients with stable angina in outpatient practice in Kursk and Chisinau
Authors: Povetkin Sergey V. , Levashova Oxana V. , Klyueva Elena G. , Ghicavii Victor I. , Batchinschi Nicolae G. , Pjdgurschi Lilia A. , Turcan Lucia M.
Published: February 2021

Aim. To study structure of medical purposes of anti-anginal, antiplatelet and hypolipidemic means at coronary heart disease patients in ambulatory practice of Kursk (Russian Federation) and Chisinau (Republic of Moldova). Materials and methods. During the period from October, 2017 to January, 2018 as a one-stage descriptive research, questioning of doctors of the medical organizations of Kursk and Chisinau was carried out. Questionnaires included questions on pharmacoepidemiological aspects of purpose of antianginal, antiplatelet and hypolipidemic means. Total number of respondents was 132, of them 66 (2 cardiologists and 64 therapists) - in Kursk and 66 (10 cardiologists and 56 therapists) - in Chisinau. Results. Doctors of Kursk and Chisinau have no statistically significant differences in structure of appointments of the main groups of anti-anginal means, antiplatelet and hypolipidemic drugs. The tendency to more frequent use of blockers of calcium channels and nitrovazodilatator among doctors of Chisinau while in structure of appointments of doctors of Kursk some prevalence of a trimetazidin, antiagregants and statines was noted was noted (p>0.05). Leaders in group of beta blockers were bisoprolol and metoprolol in the conditions of the pharmaceutical market of Kursk and Chisinau. Priority of the choice of blockers of calcium channels authentically differed in the considered regions only on a felodipin - in Kursk appointed it to a thicket (p
Safety and effectiveness of physical training in inotrop-dependent patients with compensation for chronic heart failure at the level of the III-IV functional class
Authors: Bortsova Mariia A. , Demchenko Elena A. , Fedotov Petr A. , Ganenko Olga S. , Lelyavina Tatiana A. , Galenko Viktoriia L. , Zamesov Sergei G. , Babich Oksana A. , Sitnikova Mariia Yu.
Published: February 2021

Aim. To assess the safety and effectiveness of physical training in inotrop-dependent patients with stabilization of the course of chronic heart failure (CHF) at the level of the III-IV functional class (FC). Materials and methods. The prospective randomized study included men of 18-65 years old who were committed to Almazov National medical research center "due to decompensated CHF III-IV FC, left ventricular ejection fraction of 30% or less due to coronary heart disease or dilated cardiomyopathy receiving dopamine or dobutamine for 2 weeks or more, stabilizing heart failure at level III-IV FC and arterial pressure 90/60 mm Hg and above against the background of ongoing inotropic therapy. Patients were randomized into 2 groups: 1st - those participating in the physical rehabilitation program (PRP), 2nd - receiving standard CHF therapy. Results. There was no increase in the number of fatal cases and the number of patients with episodes of decompensation of CHF in the 1st group compared with the 2nd group. The number of episodes of CHF decompensation before FC IV was higher in the 2nd group compared to the 1st: 13 (50%) in the 1st group and 20 (80%) in the 2nd (p=0.04). Episodes of CHF decompensation, requiring transfer to the anesthesiology and resuscitation departments, were 2 times less frequent in patients of the 1st group compared to the 2nd: 8 (31%) and 16 (64%), respectively (p=0.03). In patients with the 1st group, malignant ventricular arrhythmias were not registered during physical training and for 3 hours after their completion. There was a tendency (without achieving a statistically significant difference) to a decrease in pulmonary thromboembolism episodes in patients of the 1st group compared with the 2nd (p=0.05). In the 1st group, after 6 months, there was a decrease in the number of lower respiratory tract infections - bronchitis + pneumonia compared with the 2nd group (p=0.0006). Conclusion. Participation of inotropic-dependent patients in individually designed RPF does not increase their mortality and does not increase their number of life-threatening cardiac rhythm disturbances. In the group of inotropic-dependent patients participating in RPF, there was a significant decrease in the number of lower respiratory tract infections and a tendency to a decrease in the number of pulmonary embolism compared with patients not participating in RPF.
Positive effect of if-channel’s blocker ivabradine therapy in a patient with ischemic chronic heart failure with preserved left ventricle ejection fraction and hereditary thrombophilia (clinical case)
Authors: Belenkov Iurii N. , Privalova Elena V. , Ilgisonis Irina S. , Naymann Iuliia I. , Zhito Alexey V.
Published: February 2021

Chronic heart failure is one of the leading causes of mortality among patients with cardiovascular diseases. Current therapeutic methods for treating patients with chronic heart failure do not always provide a significant improvement in main intermediate and final outcomes. According to the neurohumoral theory of chronic heart failure development, an antagonism of the sympathoadrenal system with b-blockers is pathogenetically substantiated, and the drugs of this group are one of the first-line treatment for chronic heart failure. The selection of heart rate-reducing therapy in patients with chronic heart failure caused by ischemia, can often be difficult due to development of b-blockers side effects, b-blockers intolerance and/or due to the presence of contraindications at severe comorbid pathology. This article presents a clinical case of an effective administration of ivabradine, a drug of if-channel inhibitors group, in combination with b-blockers to a patient with chronic heart failure with a preserved ejection fraction.
National Medical Research Center for Preventive Medicine, Moscow, Russia
Authors: Evsyutina Yulia V.
Published: February 2021

Arterial hypertension is the leading cause of cardiovascular morbidity and mortality. According to Russian and international studies, prevalence of hypertension is approximately 40%. In the next years an increase in the number of patients can be expected. Hypertension is the main independent risk factor for coronary heart disease for all age groups. Modern antihypertensive drugs can provide good control of blood pressure and reduce the incidence of complications and mortality. By prescribing antihypertensive therapy, it is necessary to achieve the target level of blood pressure, for most patients ≤130/80 mm Hg. When prescribing combination therapy, preference should be given to fixed combinations. Approximately 10% of patients with hypertension have resistance to therapy. Such patients often need an extended diagnostic search to exclude pseudoresistance and secondary hypertension. One of the main causes of pseudoresistance is poor adherence to therapy. Patients with resistant hypertension have a higher risk of adverse outcomes compared with patients without this type of disease.
Predictors of repeat myocardial revascularization for the long-term after percutaneous coronary interventions in patients with combination of coronary artery disease and chronic obstructive pulmonary disease
Authors: Zafiraki Vitalii K. , Skaletsky Konstantin V. , Kosmacheva Elena D.
Published: February 2021

Aim. To assess the influence of concomitant chronic obstructive pulmonary disease (COPD) on the frequency of repeat myocardial revascularization in patients with coronary artery disease (CAD) after percutaneous coronary interventions (PCI), as well as to determine independent predictors of repeat revascularization in patients with concominant COPD. Materials and methods. A prospective cohort study included 646 patients with CAD, of which 254 had concominant COPD. All patients underwent PCI (46.9% for acute coronary syndrome in the main group and 44.9% in the control group. Remaining interventions were elective). The frequency of repeat myocardial revascularization and the time till re-intervention was registered during the follow-up period up to 36 months. Results. COPD increases risk of repeat myocardial revascularization (hazard ratio - HR 1.46; 95% confidence interval - CI 1.03-2.06), repeat PCI (HR 1.62; 95% CI 1.03-2.32) and is accompanied by an earlier onset of re-intervention. An independent predictors of repeat myocardial revascularization in the Cox regression model are: glomerular filtration rate (p=0.001), ankle-brachial index (p=0.004), frequent exacerbations of COPD (p=0.028), total number of coronary artery stenosis (p=0.039) and blood concentration of C-reactive protein (p=0.066). Conclusions. COPD is a significant risk factor of re-intervention after PCI in patients with acute and chronic forms of CAD and leads to its earlier performing. The patients with frequent COPD exacerbations have the highest risk of repeat myocardial revascularization during follow-up.