bluuebunny/crossref_metadata_2025 huggingface dataset:
Two-Layer Routing for High-Voltage Powerline Inspection by Cooperated Ground Vehicle and Drone
Authors: Liu Yao , Shi Jianmai , Liu Zhong , Huang Jincai , Zhou Tianren
Published: February 2019

A novel high-voltage powerline inspection system is investigated, which consists of the cooperated ground vehicle and drone. The ground vehicle acts as a mobile platform that can launch and recycle the drone, while the drone can fly over the powerline for inspection within limited endurance. This inspection system enables the drone to inspect powerline networks in a very large area. Both vehicle’ route in the road network and drone’s routes along the powerline network have to be optimized for improving the inspection efficiency, which generates a new two-layer point-arc routing problem. Two constructive heuristics are designed based on “Cluster First, Rank Second” and “Rank First, Split Second”. Then local search strategies are developed to further improve the quality of the solution. To test the performance of the proposed algorithms, practical cases with different-scale are designed based on the road network and powerline network of Ji’an, China. Sensitivity analysis on the parameters related with the drone’s inspection speed and battery capacity is conducted. Computational results indicate that technical improvement on the inspection sensor is more important for the cooperated ground vehicle and drone system.
Vascularized Iliac Bone Flap Transfer for Early and Middle Stages of Osteonecrosis of the Femoral Head
Authors: Zhao Dewei , Wang Benjie , Liu Baoyi
Published: February 2019

Background:

Osteonecrosis of the femoral head often affects young active adults and leads to destruction of the hip joint and severe arthritis
1–4
. Despite improvements in hip arthroplasty design and techniques, it is unlikely that prosthetic replacements will endure for life. Alternatively, various head-preserving procedures have been used to avert or delay the need for a total hip arthroplasty
5–11
. Vascularized iliac bone flap transfer is a joint-preserving procedure that can be considered for younger patients with early or middle-stage osteonecrosis of the femoral head.

Description:

The major steps of the procedure include (1) an anterior approach to the affected hip, (2) creation of a bone flap from the iliac crest pedicled with the ascending branch of the lateral circumflex femoral artery, (3) obtaining cancellous bone from the iliac crest, (4) exposure of the anterior aspect of the femoral neck, (5) creation of a 2 × 2-cm window at the junction of the femoral head and neck, (6) debridement and removal of the necrotic bone, (7) implantation of the cancellous bone and vascularized bone flap, (8) fixation of the bone flap, and (9) layer-by-layer wound closure. Complications are rare, and full weight-bearing is allowed at 6 months postoperatively.

Alternatives:

Alternatives to the procedure include core decompression, nonvascularized bone-grafting, free vascularized fibular grafting, and vascularized greater trochanter grafting.

Rationale:

Various femoral head-preserving procedures have been reported. Core decompression is an effective femoral head-preserving procedure and is recommended as the first surgical treatment option for symptomatic small to medium-sized precollapse lesions. However, outcomes are poor when a patient has a large lesion or femoral head collapse. The advantage of vascularized iliac bone flap transfer is that it allows femoral head decompression, restores blood supply, and provides structural support. Thus, this procedure can be performed in patients with later osteonecrosis stages before hip osteoarthritis has progressed.
Experimental Investigation of Volume Fraction in an Annulus Using Electrical Resistance Tomography
Authors: Rehman Syed Raza , Zahid Alap Ali , Hasan Anwarul , Hassan Ibrahim , Rahman Mohammad A. , Rushd Sayeed
Published: February 2019

Horizontal drilling technology has shown to improve the production and cost–effectiveness of the well by generating multiple extraction points from a single vertical well. The efficiency of hole cleaning is reduced because of the solid–cuttings accumulation in the annulus in cases of extended–reach drilling. It is difficult to study the complex flow behavior in a drilling annulus using the existing visualization techniques. In this study, experiments were carried out in the multiphase flow–loop system consisting of a simulated drilling annulus using electrical resistance tomography (ERT) and a high–speed camera. Real–time tomographic images (quantitative visualization) of multiphase flow from ERT were compared to the actual photographs of the flow conditions in a drilling annulus. The quantitative analysis demonstrates that ERT has a wide potential application in studying the hole–cleaning issues in the drilling industry.
The Uses and Gratifications Theory, Subjective Norm, and Gender in Influencing Students’ Continuance Participation Intention in LinkedIn
Authors: Paftalika Reiza Bani , Hananto Arga
Published: February 2019

This research investigated how subjective norm and motives from Uses and Gratifications Theory (UGT) affected continuance participation intention. In addition, this research examined the role of gender as a moderating variable in the relationship. A moderated regression analysis was conducted on a sample of 246 respondents selected by purposive sampling technique. The result indicates that subjective norm, all uses, and gratifications motives in the model (information seeking, self-discovery, maintaining interpersonal connectivity, social enhancement, and entertainment value) affect continuance participation intention of female students. For male students, information seeking does not significantly affect continuance participation intention. Subjective norm affects male students more strongly than female students. Then, information seeking affects female students more than male students. This research adds more insights into the literature on continuance participation intention, particularly on the role of gender.
The Meaning of Rejang Pingit Dance Performance at Geriana Kangin Village, Karangasem, Bali in the Global Era
Authors: Ruastiti Ni Made
Published: February 2019

This research was compiled from the research results that aimed to understand the meaning of Rejang Pingit dance performance in the global era. This research was conducted because of the imbalance between assumptions and reality in real life. The people who lived in the global era should be more interesting with beautiful performances that were simply performed. However, the fact was different. Although Rejang Pingit dance was very simple, people of Geriana Kangin village preserved it. The question was what was the form of the Rejang Pingit dance performance, what was the meaning contained in the performance? This research used the qualitative method. The data sources of this research were Pingit Rejang dance performance, related informants, journals, and previous research results. All data that had been collected were analyzed using aesthetic theory, religious theory, and the theory of power relations. The results show that Rejang Pingit dance is performed in the form of dance off (with no play). It can be seen from the way of presentation, choreography, performance structure, dressing, makeup, and musical accompaniment of the performance. People of Geriana Kangin village continue to preserve Rejang Pingit dance because it is considered to have the meaning of aesthetic, religious, social, and cultural. Their belief in the myth of the essence of life that undergoes the Rejang Pingit dance is so strong so that they still preserve the dance up to now.
English for Specific Purposes: A Need Analysis on English Course in Islamic Banking Department
Authors: Madkur Ahmad
Published: February 2019

This research was aimed at analyzing the type of English skills needed by the students of Islamic Banking (Perbankan Syariah) in IAIN Metro and figuring out the materials relevant to their needs. This was a qualitative study involving 25 students and 20 alumni who were working or had ever worked in the banks or BMTs. The data were obtained by employing interviews, questionnaires, documentation, and then analyzed by using Miles and Huberman model. The findings reveal that most of the students have less skill in English. However, the language skill that is needed at most by the students is speaking skill as the communicative skill and vocabulary as the language skill. It is also discovered that there are some problems, such as limited references, lack of supporting facilities, and learning duration that are encountered by both lecturers and the students. Then, referring to their needs, the materials do not yet accommodate the content focus in which the students can learn English related to banking issues. This research recommends that the syllabus should be revised and English should be taught in an integrative approach.
PARMI (Production, Attention, Retention, Motivation, and Innovation): An alternative to improving scientific writing skills
Authors: Mulyaningsih Indrya , Suwandi Sarwiji , Setiawan Budhi , Rohmadi Mohammad
Published: February 2019

This research aimed to describe the development of scientific writing model based on PARMI. The stages included: creating prototypes; and developing models through four stages, focus group discussions, experts’ considerations, limited trials, and extensive trials. The research involved students and lecturers from STAIB (Islamic Bunga Bangsa Institute), STAIC (Islamic Institute of Cirebon), STAIMA (Islamic Institute of Ma’had Ali), and ISIF (Fahmina Institute of Islamic Studies) between July and December 2014. In these model included a philosophical foundation, either a concept or a principal; its application; and its effects. It finds that based on expert judgment, this model is feasible to be developed and piloted. The results of the limited trials provide some improvement, especially on the application of PARMI. Based on the results of extensive trials it can be concluded that PARMI can improve students’ ability in scientific writing.
Ease of Online Ojek Service Grows Consumer Loyalty
Authors: Hariyatno Hariyatno , Wimpertiwi Dotty , Isanawikrama Isanawikrama , Bawono Adhi
Published: February 2019

The purpose of this research was to find out why people in the city of Bogor tend to be loyal to ojek online compared to other public transportations. This research conducted in Bogor that used descriptive and verification methods by taking 115 samples of consumers of all fleets motorcycle ojek online in Bogor. The data were taken randomly by using iteration calculation as much as three times. Data analysis used multiple regression analysis. The result of the research shows that the most significant customer loyalty of sub-variable of service quality is reliability. Of the overall population, sub-service quality variables affect customer loyalty 89,5% and the remaining 10,5% is influenced by other factors not examined in this research.
From start-up to heavy clogging: performance evaluation of horizontal subsurface flow constructed wetlands during 10 years of operation
Authors: Vasconcellos Gabriel Rodrigues , von Sperling Marcos , Ocampos Roberta Silva
Published: February 2019

The objective of this work is to evaluate the performance of two horizontal subsurface flow constructed wetlands, one planted with cattail (Typha latifolia) and the other unplanted. The distinguishing feature of this study is that it spans a period of more than 10 years, from start-up to a final operation with heavy clogging and full overland flow. For most of the time, starting in June 2007, the system received municipal sewage previously treated in an upflow anaerobic sludge blanket (UASB) reactor, but for one specific period, the pre-treatment was comprised of the UASB reactor and a trickling filter in series. The two constructed wetlands worked in parallel, each serving approximately 50 p.e. and continuously receiving a flow around 7.5 m3 d−1 for most of the time. The beds had a length of 25 m and a width of 3 m and were filled with blast furnace slag. For most of this long operational period, performance was very good in terms of biochemical oxygen demand (BOD), chemical oxygen demand (COD) and total suspended solids (TSS), with median effluent concentrations of 19/18, 46/52 and 12/8, respectively (planted/unplanted units). Clogging was noticeable in the first years of operation, soon leading to overland flow. However, treatment performance was still successful, even when the system's hydraulics were strongly deteriorated. The type of pre-treatment and the applied loads influenced more the performance of the units than the period of operation itself, evidencing the robustness of the system.
Recent Development on Anti-Obesity Compounds and their Mechanisms of Action: A Review
Authors: Qiu Yixing , Yu Huanghe , Zeng Rong , Guo Shiyin , Daniyal Muhammad , Deng Zeyu , Wang Aibing , Wang Wei
Published: February 2019

Obesity, associated with a series of complications such as diabetes, hypertension, and heart disease, is a great threat to human health and leads to increased morbidity and mortality. Despite the presence of anti-obesity agents on the market, the application of these drugs is limited because of their typical side effects. More effective and safe weight-loss drugs are being pursued by many researchers, correspondingly, growing small molecules and natural products with anti-obesity effects have been identified and the molecular mechanisms underlying the action of the novel and known compounds have at least partially been revealed. Therefore, the field does witness great progress year by year. In this review, we intend to provide a comprehensive and updated view on the known and novel compounds which possess anti-obesity effects and further classify them according to the molecular mechanisms of their actions in regulating the major anti-obesity pathways.
The Mechanisms of Actions of Aldosterone and its Antagonists in Cardiovascular Disease
Authors: Pantelidis Panteleimon , Sideris Michail , Viigimaa Margus , Avranas Konstantinos , Deligkaris Pavlos , Zografou Ioanna , Lovic Dragan
Published: February 2019

Background:

Aldosterone, through its actions on Mineralcorticosteroid Receptors (MR), controls fluid and electrolyte balance, but also exerts various direct deleterious actions on the vasculature. A number of aldosterone antagonists have been manufactured to reverse these effects.

Objective:

A comprehensive review of the underlying mechanisms of the actions of aldosterone and its antagonists in cardiovascular disease.

Method:

The relevant studies indexed in PubMed, Scopus and Google Scholar databases, published from 2003 to May 2018 were identified and reported.

Results:

Aldosterone binds to MR, activating them as intracellular transcription factors. Moreover, aldosterone, through its actions on MR, as well as on another not fully explored class of receptors, triggers several signaling pathways that produce rapid, non-genomic actions. In the vasculature, all these changes favor the establishment of inflammation and cardiovascular dysfunction, which, in turn, lead to or exacerbate various cardiovascular diseases. Mineralcorticosteroid Antagonists (MRA) are compounds that antagonize the action of aldosterone on MR. Spironolactone was the first steroidal MRA to be commercially used. It showed beneficial clinical results, but also a number of adverse effects. The next generation of steroidal MRA, exhibited lower potency but did not induce many of these adverse reactions, due to their high selectivity for MR. The third generation of MRA compromises the newly introduced non-steroidal MRA, which have a completely different chemical structure, they induce different and more drastic changes to MR, they are much more specific and currently under clinical trials.

Conclusion:

New MRA, which block the aldosterone induced pathways in the vasculature, hold promising results for the treatment of cardiovascular disease.
A Novel Oral Glutarimide Derivative XC8 Suppresses Sephadex-Induced Lung Inflammation in Rats and Ovalbumin-induced Acute and Chronic Asthma in Guinea Pigs
Authors: Ferko Boris , Romanova Julia , Rydlovskaya Anastasia V. , Kromova Tatyana A. , Proskurina Oxana V. , Amelina Anna N. , Schmutz Helmut , Renner Andreas , Nebolsin Vladimir E.
Published: February 2019

Background:

Corticosteroids are the preferred option to treat asthma, however, they possess serious side effects and are inefficient in 10% of patients. Thus, new therapeutic approaches for asthma treatment are required.

Objective:

To study the efficacy of a novel glutarimide derivative XC8 in a Sephadex-induced lung inflammation in rats as well as in acute and chronic ovalbumin-induced allergic asthma in guinea pigs.

Method:

Rats were treated with 0.18-18 mg/kg of XC8 intragastrically 4 times (24 h and 1 h prior to and 24 h and 45 h after endotracheal administration of Sephadex). The number of inflammatory cells in bronchoalveaolar lavages (BAL) was determined. Guinea pigs were treated with 0.045 -1.4 mg/kg (acute asthma) or with 1.4 and 7.0 mg/kg of XC8 (chronic asthma) intragastrically following the sensitization with ovalbumin and during aerosol challenge. Lung inflammation, numbers of eosinophils (BAL and lung tissue), goblet cells, degranulating mast cells and specific airway resistance (sRAW) were determined. The comparator steroid drug budesonide (0.5 mg/kg for rats and 0.16 mg/kg for guinea pigs) was administered by inhalation.

Results:

XC8 reduced influx of eosinophils into BAL in Sephadex-induced lung inflammation model in rats (by 2.6-6.4 times). Treatment of acute asthma in guinea pigs significantly reduced eosinophils in guinea pigs in BAL (from 55% to 30%-39% of the total cell count) and goblet cells in lung tissue. In a model of acute and chronic asthma, XC8 reduced significantly the number of eosinophils and degranulating mast cells in the lung tissue. Treatment with XC8 but not with budesonide decreased the specific airway resistance in acute and chronic asthma model up to the level of naive animals.

Conclusion:

XC8 induced a profound anti-inflammatory effect by reducing eosinophils in BAL and eosinophils and degranulating mast cell numbers in the airway tissue. The anti-asthmatic effect of XC8 is comparable to that of budesonide. Moreover, in contrast to budesonide, XC8 was capable to reduce goblet cells and airway resistance.
Using PBPK Modeling to Predict Drug Exposure and Support Dosage Adjustments in Patients With Renal Impairment: An Example with Lamivudine
Authors: Shah Kushal , Fischetti Briann , Cha Agnes , Taft David R.
Published: February 2019

Background:

Lamivudine is a nucleoside reverse transcriptase inhibitor used to treat HIV and
hepatitis B. It is primarily cleared by the kidney with renal secretion mediated by OCT2 and MATE.

Objective:

To use PBPK modeling to assess the impact of renal impairment on lamivudine
pharmacokinetics using the Simcyp® Simulator.

Methods:

The model incorporated the Simcyp® Mechanistic Kidney Model option to predict renal disposition.
The model was initially verified using the Simcyp® Healthy Volunteer population. Two discrete patient
populations were then created for moderate (GFR 10-40 mL/min) and severe (GFR < 10 mL/min) renal
failure (RF), and model simulations were compared to published data. The developed model was then
utilized in a clinical study evaluating the clinical experience and plasma exposure of lamivudine when
administered at higher than recommended doses to HIV-infected patients with varying degrees of renal
impairment.

Results:

Predicted systemic exposure metrics (Cmax, AUC) compared favorably to published clinical data
for each population, with the following fold errors (FE, ratio of predicted and observed data) for
Cmax/AUC: Healthy Volunteers 1.04/1.04, Moderate RF 1.03/0.78, Severe RF 0.89/0.79. The model captured
lamivudine plasma concentrations measured pre- and post-dose (0.5-1.5hr) in study participants (n =
34). Model simulations demonstrated comparable systemic profiles across patient cohorts, supporting the
proposed dosage adjustment scheme.

Conclusion:

This study illustrates how PBPK modeling can help verify dosing guidelines for patients with
varying levels of renal impairment. This approach may also be useful for predicting potential changes in
exposure during renal insufficiency for compounds undergoing clinical development.
Idiosyncratic Drug-Induced Acute Liver Failure: A Challenging and Distressing Scenario
Authors: Colaci Carla Stefania , Mendizabal Manuel , Bessone Fernando
Published: February 2019

Background:

Idiosyncratic Drug Induced Liver Injury (DILI) is a rare adverse event to drugs
that occasionally leads to severe liver damage, being one of the leading causes of Acute Liver Failure
(ALF) in developed countries. DILI is largely a diagnosis of exclusion.

Discussion and Conclusion:

Careful history of drug taking and ruling out other competing etiologies is
mandatory given that DILI can present with an extremely variable phenotype. Several prognostic scores
have been developed to promptly identify patients with potential risk of developing ALF. New biomarkers
to diagnose and predict DILI evolution are under study and hopefully we will benefit from these novel tools
in the near future
Citalopram-Associated Alopecia: A Case Report and Brief Literature Review
Authors: Hekmatjah Joshua , Tareen Kinza , Tareen Ruqiya Shama
Published: February 2019

Background:

Selective Serotonin Reuptake Inhibitors (SSRIs) are the first-line treatments for various psychiatric disorders. SSRIs offer an improved side effect profile compared to older treatments, which improves patients’ adherence and quality of life.

Case Report:

Here we discuss a case of an uncommon, but a distressing side effect of citalopram. A 76-year old woman was referred to the psychiatry clinic for bizarre behavior. The patient was diagnosed with behavioral variant frontotemporal dementia and was started on citalopram 20 mg and aripiprazole 5 mg daily. At 3.5 months the patient complained of diffuse hair thinning on her scalp. Citalopram was considered the offending agent and was discontinued. Within a few months, the patient regained most of her hair. Although drug-induced alopecia is common among other SSRIs, it is relatively rare with citalopram.

Results and Conclusion:

Early recognition, withdrawal of offending agent, and reassurance to the patient that hair loss is reversible can help alleviate patient distress and avoid relapse.
Macrophages in Bone Homeostasis
Authors: Kong Lingbo , Wang Youhan , Smith Wanli , Hao Dingjun
Published: February 2019

Aberrant or prolonged immune responses has been proved to be involved in bone homeostasis. As a component of the innate immune system, macrophages play a critical role in bone homeostasis. Conventionally, according to response to the various panel of stimuli, macrophages can be plastically classified into two major phenotypes: M1 and M2. M1 macrophages are generally proinflammatory, whereas M2 are anti-inflammatory. Although studies demonstrated that both M1 and M2 phenotypes have been implicated in various inflammatory bone diseases, their direct role in bone homeostasis remains unclear. Thus, in this review, we briefly discuss the term “osteoimmunology”, which deals with the crosstalk and shared mechanisms of the bone and immune systems. In addition, we overview M1 and M2 macrophages for their role in osteoclastogenesis and osteogenesis as well as relevant signaling cascades involved.
A Real-Time Early Warning System for Monitoring Inpatient Mortality Risk: Prospective Study Using Electronic Medical Record Data (Preprint)
Authors: Ye Chengyin , Wang Oliver , Liu Modi , Zheng Le , Xia Minjie , Hao Shiying , Jin Bo , Jin Hua , Zhu Chunqing , Huang Chao Jung , Gao Peng , Ellrodt Gray , Brennan Denny , Stearns Frank , Sylvester Karl G , Widen Eric , McElhinney Doff B , Ling Xuefeng
Published: February 2019

BACKGROUND

The rapid deterioration observed in the condition of some hospitalized patients can be attributed to either disease progression or imperfect triage and level of care assignment after their admission. An early warning system (EWS) to identify patients at high risk of subsequent intrahospital death can be an effective tool for ensuring patient safety and quality of care and reducing avoidable harm and costs.

OBJECTIVE

The aim of this study was to prospectively validate a real-time EWS designed to predict patients at high risk of inpatient mortality during their hospital episodes.

METHODS

Data were collected from the system-wide electronic medical record (EMR) of two acute Berkshire Health System hospitals, comprising 54,246 inpatient admissions from January 1, 2015, to September 30, 2017, of which 2.30% (1248/54,246) resulted in intrahospital deaths. Multiple machine learning methods (linear and nonlinear) were explored and compared. The tree-based random forest method was selected to develop the predictive application for the intrahospital mortality assessment. After constructing the model, we prospectively validated the algorithms as a real-time inpatient EWS for mortality.

RESULTS

The EWS algorithm scored patients’ daily and long-term risk of inpatient mortality probability after admission and stratified them into distinct risk groups. In the prospective validation, the EWS prospectively attained a c-statistic of 0.884, where 99 encounters were captured in the highest risk group, 69% (68/99) of whom died during the episodes. It accurately predicted the possibility of death for the top 13.3% (34/255) of the patients at least 40.8 hours before death. Important clinical utilization features, together with coded diagnoses, vital signs, and laboratory test results were recognized as impactful predictors in the final EWS.

CONCLUSIONS

In this study, we prospectively demonstrated the capability of the newly-designed EWS to monitor and alert clinicians about patients at high risk of in-hospital death in real time, thereby providing opportunities for timely interventions. This real-time EWS is able to assist clinical decision making and enable more actionable and effective individualized care for patients’ better health outcomes in target medical facilities.
Uji Aktivitas Antioksidan Infusa Daun Ungu Dengan Metoda DPPH (1,1- diphenil- 2-picrylhidrazil)
Authors: Salim Reny
Published: February 2019

Tanaman  ungu merupakan salah satu jenis tanaman yang berkhasiat sebagai tanaman obat. Masyarakat memanfaatkan tanaman ini sebagai obat wasir, demam, bisul, melancarkan haid, dan lain-lain. Khasiat yang dimiliki oleh daun dari tanaman wungu ini disebabkan oleh keberadaan senyawa metabolit sekunder. Secara penampilan fisik dan hasil penelitian yang telah dilakukan sebelumnya tentang daun dari tanaman Wungu ini dapat diyakini adanya senyawa antosianin dari golongan polifenol. Senyawa antosianin dari golongan fenol merupakan senyawa yang dapat dimanfaatkan sebagai zat antioksidan, maka dilakukanlah pengujian aktivitas antioksidan dari infusa daun tanaman Wungu ini. Metoda ekstraksi yang dipilih adalah infusa karena masyarakat pada umumnya mengolah daun ini dengan cara merebus daunnya lalu meminum airnya. Daun Wungu yang dibuat infusa mempunyai konsentrasi 10% lalu diencerkan hingga pada konsentrasi (75, 100, 125, 150, 175) µg/mL. Setiap infusa tersebut diambil 1 mL direaksikan dengan 2 mL larutan DPPH 35 µg/mL dalam tabung reaksi berlapis aluminium selama waktu optimum (30 menit).  Setelah waktu optimum tercapai maka dilakukan pengukuran absorbansi menggunakan spektrofotometri UV-Vis pada panjang gelombang 515 nm. Hasil pengukuran memberikan data bahwa aktivitas antioksidan berdasarkan IC50 dari infusa daun Wungu berada pada konsentrasi 125,09 µg/mL. Nilai IC50 yang diperoleh infusa dibandingkan dengan nilai inhibisi dari larutan vitamin C yang dibuat dengan variasi konsentrasi (10, 12, 14, 16, 18) µg/mL, didapatkan kesimpulan bahwa aktivitas antioksidan dari infusa daun dari tanaman Wungu tergolong sedang.
Assessing users' perception of Facilities Management services in a Public University: A case study approach
Authors: Oladokun Sunday Olarinre , Ajayi Cyril Ayodele
Published: February 2019

Facilities play a vital role in the attraction and retention of quality staff and students in tertiary institution. Hence, the perception of these facilities users is important in assessing Facilities Management (FM) services. Few studies exist in Nigeria on FM practice in tertiary institutions. Therefore, this study investigated the perception of staff and students on FM services within the campus of one of the foremost public universities in Nigeria. This study utilised survey approach by eliciting data from staff and students through self-administered questionnaire. Data collected were analysed using descriptive statistics, factor analysis, and independent sample t-test. It was found that staff and students were more satisfied with cleaning and security services than other FM services in the study area. A significant difference was also found between the perception of staff and that of students over five out of nine categories of FM services while staff were more satisfied in in all the five. The findings suggest the need for all-inclusive performance assessment of FM units and the need to embrace a more user-focused FM policy in tertiary institution. Further research covering more tertiary institutions and other stakeholders within university system may provide more generalisable results.
Analisis Kadar b-Karoten Buah Pisang Raja (Musa Paradisiacal L) dan Pisang Kepok (Musa Paradisiaca Forma Typica) dengan Metode Spektrofotometri UV-Vis
Authors: Zarnila Zarnila , Napitupulu Mery , Jura Minarni Rama
Published: February 2019

Banana fruit is a fruit that contains many nutrients. One of that is b-carotene, b-carotene is a provitamin that plays an important role in the formation of vitamin A. This study aimed to determine the levels of β-carotene in raja and kepok bananas. This research used a qualitative and quantitative method, which is the qualitative method using TLC while the quantitative method using UV-Vis spectrophotometry. The TLC results obtained that Rf b-carotene comparison was 0.97 cm, Rf of banana raja extract was 0.96 cm and banana kepok extract was 0.97 cm. Based on the UV-Vis spectrophotometry result, b-carotene content of raja banana fruit was 0.222 mg/100 grams while the kepok banana fruit was 0.261 mg/100 grams, therefore the highest level was banana kepok.
Biocharcoal dari Kulit Rambutan (Nephelium lappaceum L.) sebagai Adsorben Zink dan Tembaga
Authors: Setiawan I Ketut Ardi , Napitupulu Mery , Walanda Daud K.
Published: February 2019

Rambutan peel is one source of biocharcoal production to adsorb metal ions because of the potential of cellulose content. This study aimed to describe the characteristics of biocharcoal from rambutan peel as well as to determine biocharcoal adsorption to zinc and copper based on the variation of biocharcoal weight and metal ions concentrations. The method used in this study was a laboratory experiment, and metals were analyzed using spectrophotometer spectroDirect. The results showed the moisture and ash levels of the biocharcoal were 0.4% and 5.4%, respectively. The optimum weight of biocharcoal to adsorb Zn and Cu ions was 40 mg with their percentage adsorption of 98.81% and 98.94%, respectively. The optimum concentration adsorption of biocharcoal to Zn ions was 40 ppm with the percentage adsorption of 98.32%, while for the Cu ions was 60 ppm with the percentage adsorption of 98.25%.
Retrospective CBCT analysis of airway volume changes after bone-borne vs tooth-borne rapid maxillary expansion
Authors: Kavand Golnaz , Lagravère Manuel , Kula Katherine , Stewart Kelton , Ghoneima Ahmed
Published: February 2019

Objectives:

To compare changes in upper airway volume after maxillary expansion with bone- and tooth-borne appliances in adolescents and to evaluate the dentoskeletal effects of each expansion modality.

Materials and Methods:

This retrospective study included 36 adolescents who had bilateral maxillary crossbite and received bone-borne maxillary expansion (average age: 14.7 years) or tooth-borne maxillary expansion (average age: 14.4 years). Subjects had two cone beam computed tomography images acquired, one before expansion (T1) and a second after a 3-month retention period (T2). Images were oriented, and three-dimensional airway volume and dentoskeletal expansion were measured. Analysis of variance was used to test for differences between the two expansion methods for pretreatment, posttreatment, and prepost changes. Paired t-tests were used to test for significance of prepost changes within each method.

Results:

Both groups showed significant increase only in nasal cavity and nasopharynx volume (P < .05), but not oropharynx and maxillary sinus volumes. Intermolar and maxillary width increased significantly in both groups (P < .05); however, the buccal inclination of maxillary molars increased significantly only in the tooth-borne group (P < .05). There was no significant difference between tooth- and bone-borne expansion groups, except for the significantly larger increase in buccal inclination of the maxillary right first molar after tooth-borne expansion.

Conclusions:

In adolescents, both tooth- and bone-borne RME resulted in an increase in nasal cavity and nasopharynx volume, as well as expansion in maxillary intermolar and skeletal widths. However, only tooth-borne expanders caused significant buccal tipping of maxillary molars.
Fenofibrate Rescues Diabetes-Related Impairment of Ischemia-Mediated Angiogenesis by PPARα-Independent Modulation of Thioredoxin-Interacting Protein
Authors: Yuan Jun , Tan Joanne T.M. , Rajamani Kushwin , Solly Emma L. , King Emily J. , Lecce Laura , Simpson Philippa J.L. , Lam Yuen Ting , Jenkins Alicia J. , Bursill Christina A. , Keech Anthony C. , Ng Martin K.C.
Published: February 2019

Fenofibrate, a peroxisome proliferator–activated receptor α (PPARα) agonist, reduces lower limb amputations in patients with type 2 diabetes. The mechanism is, however, unknown. In this study, we demonstrate that fenofibrate markedly attenuates diabetes-related impairment of ischemia-mediated angiogenesis. In a murine model of hindlimb ischemia, daily oral fenofibrate treatment restored diabetes-impaired blood flow recovery, foot movement, hindlimb capillary density, vessel diameter, and vascular endothelial growth factor signaling to nondiabetic levels in both wild-type and PPARα-knockout mice, indicating that these fenofibrate effects are largely PPARα independent. In vitro, fenofibric acid (FFA) rescued high glucose–induced (25 mmol/L) impairment of endothelial cell migration, tubulogenesis, and survival in a PPARα-independent manner. Interestingly, fenofibrate in vivo and FFA in vitro reversed high glucose–induced expression of thioredoxin-interacting protein (TXNIP), an exquisitely glucose-inducible gene previously identified as a critical mediator of diabetes-related impairment in neovascularization. Conversely, adenoviral overexpression of TXNIP abrogated the restorative effects of FFA on high glucose–impaired endothelial cell function in vitro, indicating that the effects of FFA are mediated by TXNIP. We conclude that fenofibrate rescues diabetic impairment in ischemia-mediated angiogenesis, in large part, by PPARα-independent regulation of TXNIP. These findings may therefore explain the reduction in amputations seen in patients with diabetes treated with fenofibrate.
Effect of a Behavioral Weight Loss Intervention in People With Serious Mental Illness and Diabetes
Authors: Tseng Eva , Dalcin Arlene T. , Jerome Gerald J. , Gennusa Joseph V. , Goldsholl Stacy , Cook Courtney , Appel Lawrence J. , Maruthur Nisa M. , Daumit Gail L. , Wang Nae-Yuh
Published: February 2019

OBJECTIVE

Given the high prevalence of obesity and diabetes in patients with serious mental illness (SMI) and the lack of evidence on the effects of weight loss programs in SMI patients with diabetes, we evaluated the effectiveness of a behavioral weight loss intervention among SMI participants with and without diabetes.

RESEARCH DESIGN AND METHODS

Using data from ACHIEVE, a randomized controlled trial to evaluate the effects of a behavioral weight loss intervention among overweight/obese people with SMI, we assessed and compared weight change from baseline to 18 months in participants with and without diabetes using a longitudinal mixed-effects model.

RESULTS

Of the 291 trial participants, 82 (28.2%) participants had diabetes (34 and 48 in intervention and control groups, respectively) at baseline. Participants with diabetes were more likely to be taking antipsychotics (31.7% vs. 18.7%, P = 0.02). At 18 months, participants in the control group with diabetes lost 1.2 lb (0.6%) of body weight compared with 0.8 lb (0.7%) among those without diabetes. In the intervention group, participants with diabetes lost 13.7 lb (6.6%) of their initial body weight compared with 5.4 lb (2.9%) for those without diabetes. Corresponding net effects (intervention minus control) were 4.6 lb (2.2%) and 12.5 lb (6.0%) net weight reduction over 18 months in the no diabetes and the diabetes subgroups, respectively. However, the between-group difference in intervention effects was statistically nonsignificant (absolute weight change: P-interaction = 0.08; % weight change: P-interaction = 0.10).

CONCLUSIONS

A behavioral weight loss intervention is effective among overweight and obese individuals with SMI regardless of their diabetes status.
Connectedness: How Technology and Social Networks Are Advancing Diabetes Nutrition Care
Authors: Boucher Jackie L.
Published: February 2019

Editor's Note: This article is adapted from the address Ms. Boucher delivered as the recipient of the American Diabetes Association’s (ADA’s) Outstanding Educator in Diabetes Award for 2018. She delivered the address in June 2018 at the association’s 78th Scientific Sessions in Orlando, Fla. A webcast of this speech is available for viewing at the ADA website (professional.diabetes.org/webcast/outstanding-educator-diabetes-award-lecture%E2%80%95connectedness%E2%80%94how-technology-and-social-networks).
Del continuo transitar entre la lingüística y la didáctica de la lengua. Narrativas biográficas en torno a Adolfo González Martínez
Authors: Trigo Ibáñez Ester , Romero Oliva Manuel Fco. , Ayora Esteban M.ª Carmen
Published: February 2019

El presente trabajo, enmarcado dentro de la narrativa biográfica, se adentra, a partir de una serie de entrevistas y conversaciones, en las historias de vida de María del Carmen Ayora Esteban y de Ester Trigo Ibáñez bajo un nodo común: la figura de Adolfo González Martínez. De esta forma, se realizará un recorrido, atravesando el tiempo y el espacio, evocando a distintos investigadores del ámbito que transitaron por diversos escenarios y compartieron momentos emblemáticos. Este viaje nos ayudará a comprender, por un lado, la personalidad de nuestro protagonista, honrando su memoria y, por otro, los desarrollos de la Disponibilidad léxica en España desde la voz de nuestras informantes.
Disponibilidad léxica y socionomástica
Authors: Fernández Juncal Carmen , Hernández Muñoz Natividad
Published: February 2019

El estudio de los nombres propios, sobre todo desde el punto de vista de su evolución en el uso y los diferentes valores sociales que han desarrollado a lo largo del tiempo, ha presentado dificultades evidentes para su captación más allá de los trabajos de frecuencias. En la presente investigación abordamos un análisis socionomástico de los antropónimos desde los postulados metodológicos de la disponibilidad léxica, a partir de una muestra restringida geográficamente y con distribución homogénea según diversos parámetros sociales (edad, género y nivel sociocultural). Los resultados confirman, en primer lugar, la idoneidad del procedimiento a la hora de detectar esquemas y modelos de hábitos onomásticos, así como la posibilidad de establecer comparaciones con otros recuentos de frecuencia ya existentes. Por otra parte, a partir del análisis cuantitativo, es posible detectar comportamientos diferenciados entre los colectivos que resultan de la estratificación de la muestra a partir de los cuales se pueden trazar tendencias y patrones en el conjunto social.
Observación de la brecha tecnológica generacional desde el prisma de la disponibilidad léxica
Authors: Ávila Muñoz Antonio Manuel , Santos Díaz Inmaculada Clotilde
Published: February 2019

Las nuevas tecnologías han provocado cambios en el sistema educativo, económico y social. Esta circunstancia ha favorecido la aparición de diferencias sustanciales en las posibilidades de acceso a la formación, ocio, cultura y servicios de los individuos, instituciones y países. La brecha digital, definida como la desigualdad que genera la ausencia de acceso a la red y a las herramientas que ofrece (Cabero Almenara, 2014), conlleva la exclusión —en mayor o menor medida— de la sociedad del conocimiento. Uno de los aspectos en los que se refleja esa brecha podría ser el vocabulario que poseen las personas según sus oportunidades de acceso a las nuevas tecnologías. Este artículo tiene como principal objetivo observar la posible existencia de una brecha generacional tecnológica a partir del estudio de unos listados de léxico disponible basados en ocho centros de interés relacionados directa o indirectamente con las Tecnologías de la Información y el Conocimiento (TIC) y de un cuestionario sociológico. La muestra de estudio está formada, por un lado, por estudiantes preuniversitarios y, por otro, por estudiantes de un centro de Educación Permanente de Adultos de Málaga. Buscamos conocer y analizar el léxico disponible relacionado con las nuevas tecnologías de la población considerada. La correlación entre las variables léxicas y sociológicas nos ofrecerán información relevante sobre asociaciones y condicionantes en ambos sentidos. Se parte de la hipótesis de que las generaciones de mayores poseen menor cantidad de léxico referido a las nuevas tecnologías. Además, ese léxico cubre un abanico muy general y superficial de las aplicaciones tecnológicas. En cambio, los jóvenes de instrucción media preuniversitarios poseen más cantidad de léxico y, seguramente, más especializado y específico. Los resultados muestran una gran disparidad entre el vocabulario recogido en los grupos de jóvenes y adultos. Con este estudio pretendemos contribuir a la creación de acciones que palien los efectos adversos de la brecha tecnológica generacional en los grupos más vulnerables desde el punto de vista social.
Incidencia del factor sexo en el léxico disponible de una comunidad bilingüe
Authors: Calero Fernández M. ª Ángeles , Zapata Maribel Serrano
Published: February 2019

Una de las variables sociolingüísticas tenida en cuenta, tradicionalmente, en los estudios sobre variación léxica es el sexo(o género). En el presente trabajo pretendemos conocer la incidencia de esta variable sobre el léxico disponible en castellano y en catalán en la provincia de Lleida. Concretamente, analizamos mediante procedimientos estadísticos la influencia que ejerce este factor en la producción del léxico en las dos lenguas en una muestra de 240 informantes bilingües de entre 17 y 18 años con estudios secundarios. Comprobamos 1) que las mujeres obtienen mejores índices de producción; 2) que existe una relación entre qué sexo evoca más palabras en cada centro de interés y la atribución social a la esfera femenina o masculina de la realidad que engloba dicho centro; 3) que las mujeres se están sustrayendo a la prohibición de utilizar palabras malsonantes y 4) que, en cambio, mantienen rasgos propios de la afectividad lingüística. Sucede en ambas lenguas en contacto, aunque con ciertas diferencias reseñables.
An Experiment In Breeding Cut Roses For The Indonesian Highlands
Authors: Vries D. P. de , Darliah , , Dubois Lidwien A.M.
Published: February 2019

BIOBREES is a co-operative scientific programme between Indonesia and The Netherlands, of which the rose part aims at breeding cut roses adapted to the tropical highland. Within that scope four direct plant characters of 62 cut rose genotypes in different physiological stages were studied. The genotypes originated from cross-breeding in 1995 and successive selection for cut rose properties in populations at Plant Research International, Wageningen, The Netherlands, in 1996. Plant stages stuAn died were (i) superior adult seedlings in Wageningen in 1996, (ii) clones grafted onto Natal Briar both in Wageningen and Cipanas in 1997. Clonal Plant Research International, Wageningen, Plant Research International, Wageningen, clonal plants in Cipanas had significantly shorter shoots, more thorns, smaller flowers and fewer petals than the adult seedlings in Wageningen. Clonal plants in Wageningen, however, had significantly longer shoots; more thorns, and larger flowers with more petals than the seedlings in Wageningen. Despite differences in level of expression, for each character the absence of genotype-location interaction was ascertained. The expression of characters as influenced by light (both quantitative and qualitative), temperature and cultivation is discussed in relation to selection of cut roses in the temperate zone, which are adapted to the tropical highland.
PRELIMINARY STUDY ON THE HETEROTIC PATTERN OF TROPICAL QUALITY PROTEIN MAIZE (QPM) AND DOWNY MILDEW RESISTANCE (DMR) MAIZE INBREDS
Authors: Ruswandi D.
Published: February 2019

Exploration of heterotic patterns among maize inbreds has become important since it could provide information on which new germplasm could be used to improve base population in breeding program. This experiment was a preliminary study on the heterotic relationships between tropical quality protein maize (QPM) and downy mildew resistance (DMR) maize inbreds based on analysis on combining ability. Seven tropical maize inbreds were crossed in a line × tester. One commercial hybrid from Bisi Company, Bisi 2, was included for the evaluation of hybrids as check cultivar. The result revealed that two heterotic groups has been recognized, i.e., major group consisted of CML 161, CML 163, CML 172, Nei 9008, and P345. Whereas the small group contains MR 10 and Ki 3. The hybrids and their parental inbreds were evaluated in Jatinangor, Indonesia (753 m above sea level) in 2003 to 2004. The location of yield test has a humid climate with an annual rainfall of about 1925 mm. The field experiment was arranged in a randomize block design with two replications. The present study revealed two heterotic groups: major group involving CML 161, CML 163, CML 172, Nei 9008, and Ki 3; and small group containing MR 10 and P 345. Moreover, the major group can be divided into two subgroups involving all CML lines for the first subgroup and Nei 9008 and Ki 3 for the second subgroup.