bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALYTICAL REVIEW OF APPROACHES TO THE USE OF ALTERNATIVE FEEDS IN AQUACULTURE WHEN IMPROVING ENVIRONMENTAL SCHEMES
Authors: Shaikhiev I.G. , Svergusova S.V. , Sapronova Zh.A.
Published: April 2022

Information from foreign literary sources on the possibility of growing Atlantic salmon (Salmo salar) with the inclusion of dried and / or defatted biomass of the larvae of the Black Soldier fly (Hermetia illucens) in the diet is summarized. Brief data on the physiology and life cycle of the named insect, as well as the content of proteins and fatty acids are given. It has been shown that flour from dried biomass of insect larvae contains a large amount of amino acids and fatty acids. Information on the effect of meal from insect larvae on an increase in the mass of juveniles and adults of Atlantic salmon fish, digestibility of dry matter of feed, organoleptic characteristics of fish fillets, amino acid and fatty acid composition and other indicators when replacing fish meal and soybean meal with meal from larvae is briefly presented Hermetia illucens. It was concluded that the inclusion of flour from insect biomass in certain proportions has a positive effect on the growth and vital activity of fish of the Salmo salar species, however, there are limits for inclusion in the diet. The literature also summarizes the literature on the possibility of using krill biomass in the diet for growing salmon, briefly provides information on its volume of formation and composition.
SELF-STORAGE FACILITIES AS A WAY OF THE REDEVELOPMENT OF SAINT PETERSBURG «GRAY BELT»
Authors: Barashev M. N. , Dvornikova M. I.
Published: April 2022

Self-Storage can be one of the new and profitable options for redevelopment of the «gray belt» of St. Petersburg. The purpose of the study was to estimate the current situation with the “gray belt” of St. Petersburg and the demands of the self-storage market. The following methods were desk research of the market. As a result, the current situation of the «gray belt» of St. Petersburg was described. The market attractiveness of different types of redevelopment of industrial territories (business centers, shopping malls and hotels) was analyzed. The potential of the self-storage market in St. Petersburg was studied and the demands of the market players for the location of objects were determined. It is proved that most industrial areas have a high attractiveness for self-storage. As an example, the territory of the former plant «Krasniy Treugolnik» was considered in more detail
СОNCEPTUAL APPROACH TO THE DEVELOPMENT OF THE TOURISM SECTOR OF CRIMEA: INSTITUTIONAL AND ENVIRONMENTAL ASPECTS
Authors: Pashentsev A.I. , Garmider A.A.
Published: April 2022

The Federal Target Programs of the Russian Federation and the State Programs of the Republic of Crimea in the field of tourism were systematized, which made it possible to establish their characteristics and identify the objective need for implementation in order to achieve the goals set. The author’s vision is presented and the feasibility of assessing the state management of development in the field of tourism is justified from the point of view of solving a three-unit problem: institutionalization — analysis of the implementation of the federal target program of the Russian Federation and the State PRC, a study of regional water use based on an aggregated indicator of water use, a study of the state of the environment based on a comprehensive indicator of its protection. The approach to the development of the tourism sector of Crimea is justified on the basis of: doctoral sectors of the economy — the tourism sector — related sectors of the economy working in tourism
DEFINITION OF INNOVATIVE ACTIVITY OF RUSSIAN ENTERPRISES IN FORECASTING STRATEGIC CHANGES
Authors: Shtofer G.A. , Gaysarova A.A. , Yudina A.O.
Published: April 2022

Identification of existing trends in the innovative activity of business entities is an important component of the process of forecasting strategic changes in order to strategically manage their activities. Innovative activity is manifested through innovative processes — the activity of creating, mastering in production and promoting various kinds of innovations to the market. Eliminating the causes and factors that have a negative impact on the level of innovation activity of Russian enterprises contributes to the creation of favorable conditions for the development of innovation activity in the country. This approach can be implemented through a systemic impact on the main constraining factors, primarily through the initiatives of the state, medium and large business. The use of modern mechanisms of strategic planning and forecasting as tools for the implementation of innovative projects based on strategic alternatives will contribute to solving the problems of sustainable development of enterprises, regions, and the state as a whole.
Skullcapflavone II Alleviates Lipopolysaccharide-Induced Apoptosis and Inflammation in WI-38 Cells
Authors: Wang Donglian , Hu Guoyong , Zhao Lidong , Xing Pengcheng , Zhou Minjie , Han Chao
Published: April 2022

The role of skullcapflavone II in pneumonia was investigated using lipopolysaccharide treated human lung fibroblasts WI-38 cells as a model. Lipopolysaccharide treatment led to decreased cell viability, increased cell apoptosis and inflammation. Exposure of these lipopolysaccharide-treated cells to skullcapflavone II resulted in amelioration of cytotoxic effects of the lipopolysaccharide. The reduced IκBα expression and enhanced p-IκBα and p-p65 in WI-38 cells caused by the lipopolysaccharide treatment were reversed by skullcapflavone II. In conclusion, skullcapflavone II exerts antiapoptotic and anti-inflammatory effects on lipopolysaccharide-induced WI-38 through inhibition of NF-κB pathway.
A Novel Method for Optimal Calculation of Stand-alone Renewable Energy Systems
Authors: Phan Van Duc , Vu Quang Sy , Le Huu Son , Nguyen Van Binh
Published: April 2022

Nowadays, the development and use of clean energy sources are receiving strong attention all over the world. However, the current methods used to calculate the design of these systems have proved unconvincing when the optimization is performed by "soft" optimization, and there are certain defects. In this paper, a new method for more robust optimization of independent renewable energy systems is proposed, in which the essential elements of the system such as energy characteristics are obtained in the reality of renewable energy generators or weather changes over time of the year are also considered to solve the problem of optimizing the energy system more efficiently, meet the demand for efficient energy use and optimize consumer investment costs.
New record of Yosiiella mira Hüther, 1967 (Collembola, Isotomidae, Anurophorinae) for Amazon
Authors: Cipola Nikolas G. , Villalobos Erick A. H.
Published: April 2022

Yosiiella mira Hüther, 1967 is recorded here for the first time outside Brazilian territory, in Peruvian Amazon. The species was found through of litter extraction from an ore exploration area. From this record, we believe that Y. mira could potentially be widely distributed in the Amazon biome. The Isotomidae fauna from Peru now pass for 34 species in 14 genera.
Fall from Tree: A 14 Year Study
Authors: Ashesh Gunwantrao Wankhede  , Himanshu Sharma
Published: April 2022

Background: Tribal of Bastar district of Chhattisgarh have a unique bondage of culture, foodsupply with the forests and trees of the region, during collection incidences of fall from treesoccurs many times resulting in injuries including fatal ones, study has undertaken to prevent andsuggestion for adequate implementation of treatment to specific injuries sustained during their fall.Objective: The objective of the study was to identify and analyze the injuries sustained by thetribals and local of the Bastar region in fall from tree, and to suggest measures to prevent theinjuries sustained during fall from treeMaterial and Method: A data of postmortem reports of all cases of deaths occurred in 14 years(2009 to 2012), due to fall from tree, which had been bought to the mortuary of Forensic Medicinedepartment.Results: Out of total of 99 cases evaluated, it consisted predominantly of male population of theage 31-40 years, Maximum number of fall h from the Imali(Tamarindus indica) tree- 32 cases.Maximum cases were found in the year 2015- 13 cases. Maximum cases occurred in the Month ofFebruary 16 cases. Maximum injuries from fall were on Head region 79 cases with brain contusionpredominant 23 cases. Chest injury sustained stood second 69 cases with rib fracture predominant31 cases. Abdomen region 32 cases with liver injury predominant 11 cases. Upper limb injury 32with radius/ulna fracture predominant 6 cases. Lower limb region 54 cases with femur fracturepredominant 8 cases.Conclusion: The significant number of injuries including fatal ones needs to be prevented.Adequate tree climbing programs and modernized equipment distribution need to do by forestdepartment and state government, specialized Trauma center for head and chest injury need to beestablished at block level of the Bastar region
Association between ABO Blood Group and Epistaxis among Syrian Population
Authors: Ehab Moeen Mobarek  , Mohammed Baraa Okdeh
Published: April 2022

Background: Epistaxis is one of the most common otorhinolaryngologic emergencies in ear, nose,and throat clinics. Blood grouping is routinely done in patients with epistaxis.Objectives: To determine the association between ABO blood type and epistaxis.Methods: This retrospective study involved 260 patients with idiopathic epistaxis. Patients withrisk factors for bleeding, including anticoagulant use, thrombocytopenia, hypertension, liverdiseases, elevated bleeding time, low coagulation factor levels, or any benign/malignant tumor,were excluded from the study. Thus, only patients with idiopathic epistaxis were included in thisstudy.Results: The distributions of blood groups in patients with idiopathic epistaxis were(AB < B<A<O), with highly trending with male gender. Also, more frequent in age category 6 – 12y, 13 – 20 y, 1 – 5 y, 46 – 70 y, 21 – 45 y respectively, with no pervious history of nasal trauma(71.92%). Most of patients were no correlation with nasal disorders or deformity (73.84 %), alsovast majority of them need no intervention for epistaxis i.e., conservative treatment (81.15 %).Conclusions: Our study indicates that in the Syrian population, the O blood type is over-representedin patients with idiopathic epistaxis versus the general population. We conclude that blood type Ois a risk factor for idiopathic epistaxis in the Syrian population.
Trip, Slip and Fall: ICD10 and Fall from Height
Authors: Ishita Manral  , KV Radhakrishna  , Abhijit Rudra
Published: April 2022

Background: ICD 10 has unified the diagnosis, in this study, we have studied fall from height asper ICD 10 classification of cases who reported to emergency department of tertiary care hospitalin Maharashtra. Unintentional fall from height represents a significant cause of injury in urbanpopulations.Results: In this retrospective study, data pertaining to cases which were examined and treated ata tertiary care centre in Western India was analysed from 2014-2016. A total of 44 cases qualifiedour criteria of unintentional fall from height.83% of the population study were male. 21-40 yearsof age were most commonly affected. Alcohol was a common factor amongst the falls. As the yearprogressed number of cases have decreased. W10 ICD 10, fall from stairs were the most commoncause of fall. Head injuries (42%) followed by extremities injuries were the most common.Conclusion: A significant number of non – fatal cases occur due to unintentional fall from height.There is a need to study the demographic profile of injured persons, assess the severity of theirinjuries and identify certain risk factors associated with such non-fatal injuries due to fall fromheight.
Factors Influencing Drinking among Middle-Aged People
Authors: Jeong-Sook Lee
Published: April 2022

Background: Middle age is a period of change, and many people consume alcohol to relieve thestress associated with this transition. The present study aims to investigate factors that influencedrinking among middle-aged people.Methods: This is a secondary analysis of data on social problems and cohesion that the KoreaInstitute for Health and Social Affairs. Collecting data from 1,260 middle-aged people between40 and 64 years of age, the study measured resilience, stress, and drinking. Descriptive statistics,t-tests, analysis of variance, Pearson’s correlation, and multiple regression analysis were performed.Conclusion: Multiple regression analysis that investigated factors that influenced drinking hadan explanatory power of 27.4%. The analysis also revealed that the following factors had effectson drinking among middle-aged people: gender, followed by smoking, marital status, difficultiesin daily life due to health problems, employment status, and past experiences of violence. It isnecessary to develop and implement strategies that mitigate high-risk drinking based on the factorsthat our study reveals. This would serve to promote a healthy lifestyle among the middle-agedwhile also preventing the progression to high-risk drinking.
Study on Age Determination by Epiphyseal Fusion of Distal End of Ulna and Radius in Telangana Region
Authors: K Srinivasulu  , Nakkala Supraja Internee  , Chittireddy Sainithya  , Jupaka Om Shanti
Published: April 2022

The use of radiographic data for age determination is a widely accepted method and consideredscientifically approved. The aim of the present study is to determine the age of epiphyseal union oflower end of ulna and radius among Telangana population. A cross-sectional study was conductedin the region of Telangana, with 100 participants include 50 males and 50 females, we observedthat the ossification of lower end of radius completed at 17 to 18 years in females and 19 to 20 yearsin males, whereas ossification center of lower end of ulna ossified one year earlier than radius, itossifies at 16 to 17 years in females and 18 to 19 years in males.Skeletal age is not uniform among all the participants. Ulna ossifies one year earlier than radius inboth males and females. We also observed that the ossification completed early in females than inmales. We found similar results in several studies conducted in India and abroad.
The Strategy of Provision Time Length Improvement of Medical Record Documents in Bhayangkara Lumajang Hospital with PDCA Method – Indonesia
Authors: Novita Nuraini  , Siti Sofiyah  , Rossalina Adi Wijayanti
Published: April 2022

Background: Each hospital must follow minimum service standards regarding waiting timesand the time for providing outpatient medical record documents. According to the results ofobservations, the time for providing outpatient medical record documents on the morning shift hasa total average of 22 minute while the afternoon shift has a total average of 21 minute.Methods: The purpose of this study is to improve and develop strategies to speed up the time ofproviding medical record documents at Bhayangkara Lumajang Hospital with the PDCA (Plan,Do, Check, Action) method.Results: The results and discussion can be concluded, namely the plan (planning) in an effort toimprove the time of providing medical record documents which is quite long, namely by makingtracers. Do (implementation) of the results of the plan in an effort to improve the length of timefor providing medical record documents at Bhayangkara Lumajang Hospital, by implementing theMCH system, applying tracers to medical record documents. The check can be concluded that thetime for providing medical record documents has not met the expected standard.Conclusion: Action (improvement) as a result of the agreement in Brainstorming, Action concludedthat Bhayangkara Lumajang Hospital will maintain the standard time for providing medical recorddocuments and apply the use of tracers from researchers.
Phenytoin Induced Gingival Enlargement and Its Management- A Case Report
Authors: Pragya Singh  , Nitin Tomar  , Mayur Kaushik  , Sameer Ahmad
Published: April 2022

Background: Gingival enlargement is associated with multiple factors including congenitaldiseases, hormonal disturbances, poor oral hygiene condition, inflammation, neoplasticconditions, and adverse drug reactions including anticonvulsants, calcium channel blockers,and immunosuppressants. This can have a deleterious effect on the quality of life and also onhigh oral bacterial load caused by plaque-retentive areas. Method: Various treatment modalitiesinclude both surgical (gingivectomy, periodontal flap, electrosurgery, and laser excision) andnonsurgical approaches (oral hygiene measures, oral prophylaxis, discontinuation of the drug, orthe replacement of the drug with other alternative). Conclusion: Surgical intervention is requiredwhen non-surgical treatment fails to resolve the problem. Proper maintenance phase should befollowed for better esthetic outcome along with drug replacement.
Complete Recovery Following Surgical Resection Inchildhood Pilocytic Astrocytoma
Authors: Prastiya Indra Gunawan  , RahardianIndarto Susilo  , Wihasto Suryaningtyas
Published: April 2022

Pilocytic Astrocytoma (PA) is a common type of brain tumour disease in the paediatric population.The cerebellum is the most common site of tumour origin. Here we present a 5-year-old girlwho referred with gait imbalance,truncal ataxia and tandem gait which was later radiology andpathologically identified as Pilocytic Astrocytoma. Complete surgical resection was performedand it resulted in complete recovery.Knowledge of these imaging manifestations of pilocyticastrocytoma may be helpful to early recognition and prompt treatment.
Results of Surgical Treated of Nodular Thyroid in Women
Authors: Rafa’a Sami Mahmood Al- Hayali
Published: April 2022

The long-term results of surgical treatment of nodular goiter and thyroid cancer were studied.Glands in 239 women under the age of 40 years. The patients were divided into two homogeneousgroups: 1st — operated on for differentiated thyroid cancer; 2nd - operated on for benign neoplasms.Revealed causes and frequency the occurrence of recurrence of the disease, especially the courseof postoperative hypothyroidism. The relationship of the occurrence of complications with thenosology and volume of the operation is analyzed. Evaluated the reproductive function of womenafter surgery. Tactics offered treatment of nodular goiter and thyroid cancer in pregnant women.Untreated thyroid diseases during pregnancy may lead to premature birth, preeclampsia (a severeincrease in blood pressure), miscarriage, and low birth weight among other problems. Therefore, itis important to talk to your doctor if you have had a history of hypothyroidism or hyperthyroidism soyou can be monitored before and during your pregnancy, and to be sure that your medication isproperly adjusted, if necessary.We studied the long-term results in 239 women under the age of 40 years. Patients were dividedinto two homogeneous groups: 1 - thyroid cancer, 2 - operated for benign tumors. The causesand frequency of recurrence of the disease and postoperative hypothyroidism were identified.The relation between the occurrence of com- plication’s with nosology and operation volume wasanalyzed. We evaluated the reproductive function of treatment of the goiter and thyroid cancer inpregnant women.
PROBLEMS OF APPLICATION OF MODERN TECHNOLOGIES IN CRIMINAL PROCEEDINGS
Authors: Аджимагомедова Сарат Курашевна , Турилов Георгий Георгиевич
Published: April 2022

В данной научной работе проведен анализ современных технологий при их внедрении в уголовный процесс России. Отмечаются проблемы использования технических средств в уголовном процессе, в частности, возможность монтажа, подделки и подлога. Проведен сравнительный анализ статистики применения современных технологий в уголовном процессе за период с 2013 по 2020 года.

In this scientific work, the analysis of modern technologies in their implementation in the criminal process of Russia is carried out. The problems of using technical means in criminal proceedings are noted, in particular, the possibility of installation, forgery and forgery. A comparative analysis of the statistics of the use of modern technologies in criminal proceedings for the period from 2013 to 2020 is carried out.
Emerging Gene Editing Therapies for Blood Disorders
Authors: Kesavan Gokul
Published: April 2022

Hemoglobinopathies like sickle cell disease (SCD) and beta thalassemia are the most common monogenic disorders and the number of children born every year with such conditions is predicted to reach about 400,000 by the year 2050. Transplantation of hematopoietic stem cells remains the gold standard of treatment but finding a Human Leukocyte Antigen (HLA)-matched donor is a major bottle neck when large numbers of patients need to be treated. Recent advances in gene editing tools, like Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), show immense potential to transform the gene/cell therapy scenario. This review covers recent breakthroughs in treating SCD and transfusion-dependent beta thalassemia such as re-initiation of fetal hemoglobin expression, and the planned clinical trials to correct the sickle cell mutation through CRISPR-based gene repair strategies. Further, expression of Factor IX to treat hemophilia using zinc finger nucleases, and universal Chimeric Antigen Receptor T cells (CAR-T) to treat cancers using genome editing are also discussed. Finally, challenges in developing these gene editing tools for clinical translation along with ensuring their safety, feasibility, and affordability, are also addressed.
The languages of culture: from theory to everyday life practices
Authors: Zhylenko Maria N. , Beresneva Zhanna A.
Published: April 2022

Language is an essential part of communication – it forms culture and provides it with transferring of social knowledge. Language, culture and communication are inseparable from each other and are the basis of human existence. Thorough approach to everyday life practices makes it possible to reveal their sign character and define them as specific language systems which give clear vision of aesthetic, ethical etc. peculiarities of a given epoch. Travel notes are an essential resource of our knowledge about everyday life of the nation. They offer us rich material about people, their appearance, historic events etc. Among other details travel notes contain a lot of interesting data about costume which can be regarded as a special sign system, language of culture, delivering information not only about its owner, but the whole epoch as well. The paper chose as an example the travel notes “Frigate Pallade” by I. A. Goncharov. In one of its chapters costume becomes an original communicative code for intercultural interaction.
Frontier identity of population in the border regions of Eastern Slavic states
Authors: Sapryka Viktor A. , Vavilov Andrey N. , Pastyuk Alexander V. , Sapryka Vasily A.
Published: April 2022

The paper is to study the frontier identities of population of the border regions of the Eastern Slavic states. The key theoretical and methodological approaches are the concept of “frontier”, the theory of intercultural communication and the theory of liminality. The purpose of the paper is a scientific and theoretical understanding of the identity of the frontier, which is being formed in the space of the border regions of the East Slavic states. The author emphasizes that against the background of the frontier, which causes active cross-border transcultural communication, there are noticeable variations in ethnocultural manifestations. An analysis of the geopolitical preferences of the population made it possible to conclude that the fronts were dynamic. Basing on the analysis of results of domestic and foreign studies, the paper consistently examines peculiarities of the belonging of the frontier of Ukraine, the Republic of Belarus and Russia. The results of the author's sociological research illustrate the similarity with an alternative set of the population of the border regions of Russia and Ukraine. This allowed for concluding about the main trends in the transformation of the civilizational frontier on the surface of the Eastern Slavic states — namely that the social civilizational front is not actually a “foothold” for achieving high results and rapprochement of the Eastern Slavic states, but the frequency is likely to correspond to the standard of disunity once accepted in the socio-cultural space. As the paper points out despite the transformation of civilizational fronts traditional socio-cultural space of the border regions is the main one for the assembly of the unities of the Eastern Slavic states. The author also specifies the necessity of developing a common symbolism, formulating design and defining socio-cultural codes to support the cultural community.
TikTok — a platform for youth communication or a new tool for promoting products and services?
Authors: Kashcheev Oleg V. , Yermolenko Diana E.
Published: April 2022

The social network TikTok reflects the modern culture of society and begins to exert an increasing influence on it. TikTok's content, like that of other popular social networks, is becoming more and more politicized. An important feature of the platform is its constant development aimed at meeting the users` needs. The target audience of TikTok is characterized by inherence with some of K. Jung's archetypes, the use of which in the development of advertising campaigns will increase the accuracy of impact on the audience. The use of various marketing techniques allows to make the audience more loyal to the brand, draw attention to advertising content and increase the number of views. Despite the ease of use and variety of content reflecting the cultural diversity of the world around us, today's platform structure does not let brands fully implement ad campaigns. The implementation of the presented practical recommendations for improving the platform, forms and methods of work on it, will enable TikTok in the foreseeable future to claim not only the role of a leading communication platform, but also to act as a tool for promoting goods and services.
Lexico-semantic sphere of mentality in poetic texts of Igor-Severyanin
Authors: Shliakhova Galina I.
Published: April 2022

The paper highlights the development of mental semantics in polysemic words in Igor Severyanin`s poetry. The vocabulary of the mental sphere is studied by Russian and foreign scientists, specialists in the field of semantics and related disciplines, since it is through its use that the worldview of nations and their representatives, native speakers, is reflected in language. Frequent use of a word’s figurative mental meaning in language makes such a lexico-semantic variant (LSV) commonplace, and leads to the fixation of this new seme in the explanatory dictionary. However, fictional (especially poetic) speech is characterized by greater variability of meanings. Via the author's word use in poems, words that do not have a common mental meaning develop a new semantics existing in a specific context. Severyanin is a poet who assigns an important place to the mental sphere vocabulary in his works, which makes them quite illustrative. Some words that do not have a mental seme according to their dictionary meanings acquire it in context and turn out to be the author's means of artistic expression and semantic neologisms. In a number of other cases, the opposite phenomenon is observed: in the context lexemes lose their usual mental meaning.
“Toponymic essays of the Orenburg region” by B. A. Moiseyev
Authors: Yakimov Petr A.
Published: April 2022

The popular scientific book “Toponymic Essays of the Orenburg Region” by Candidate of Philology, associate professor Boris Aleksandrovich Moiseyev from a position of the importance of the presented linguistic material for researchers in the field of toponymics, dialectology, history is reviewed. Advantages of author's interpretation of toponyms, originality in material statement, theoretical and practical importance of essays are shown. The edition opens the wide horizons not only for local history researches, but also researches devoted to interlingual and cross-cultural interaction.
IMPEDANCE SPECTROSCOPY BEHAVIORS OF CONDUCTING PANI - SrO NANO COMPOSITES
Authors:   Department of Physics, Gulbarga University, Kalaburgi- 585106, Karnataka, India, Kulkarni Anandrao. S , Ambika Prasad M.V.N ,   Department of Physics, Gulbarga University, Kalaburgi- 585106, Karnataka, India
Published: April 2022

The conducting Polyaniline/ Strontium Oxide (PANI-SrO) nanocomposites were synthesized by in-situ polymerization method with 10,20,30,40 and 50 wt.% of SrO in polyaniline. The nanocomposites thus formed were characterized by X-ray diffraction (XRD), Scanning Electron Microscope (SEM) and EDAX. The variation of impedance as a function of applied frequency suggesting nearly Debye-type relaxation mechanism take place. The results obtained for these nanocomposites are of scientific and technological interest
Cloud-based Project Management System for Engineering Students
Authors:   Department of computer engineering, Terna Engineering College, Nerul, Navi Mumbai, University of Mumbai, Maharashtra, India., Jena Sudhanshu , Manjrekar Tejas ,   Department of computer engineering, Terna Engineering College, Nerul, Navi Mumbai, University of Mumbai, Maharashtra, India.
Published: April 2022

Project Management System is a very important tool in project planning. It not only plans the entire project timeline but also helps in analyzing errors and reducing the errors and mistakes that generally arise during making a good project. Good projects need proper planning and good tools that can help in reducing errors. Project management helps in testing the number of tasks and can help users to make good projects. The main objective of our paper is to identify the main characteristics we should look for while creating a website for a cloud-based project management system for engineering students. We will aim to address all the potential issues and keys with a proper explanation of how to use the discussed characteristics through the use of some solved examples to create a better user-interacted and user-specific cloud-based project management system application.
SARS-CoV-2 and the Guillain-Barré syndrome – features for a complex association
Authors:   ", Schreiner Thomas Gabriel ,   Gr.T. Popa",   University of Medicine and Pharmacy, Iasi, Romania,   Neurology Department, Clinical Rehabilitation Hospital, Iasi, Romania,   "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania, Schreiner Oliver Daniel ,   "Gr.T. Popa" University of Medicine and Pharmacy, Iasi, Romania
Published: April 2022

Background. Guillain-Barré syndrome (GBS), the most common cause of flaccid motor deficit with acute or subacute onset, is associated in approximately 2/3 of cases with a history of microbial, predominantly viral, infection. In the context of the current COVID-19 pandemic, the presence of patients with both peripheral nervous system pathology and SARS-CoV-2 viral infection raised questions among researchers whether there may be a possible link between the two entities. Thus, this narrative review aims to provide a clearer perspective on this topic, addressing several issues. Methods. The authors performed independent research of the available literature in the most important electronic databases (PubMed, Google Scholar, and Science Direct). After applying the exclusion criteria, the reviewers focused on the most relevant articles published during the last 18 months, focusing on epidemiological and pathophysiological data regarding GBS and COVID-19. Results. In the first part, a summary of the most important results from the literature on the epidemiological situation in different parts of the world was conducted. Subsequently, possible immunological theories are presented in order to explain the epidemiological association between GBS and COVID-19 infection. Finally, the authors propose new research directions on the topic, discussing the issue of the COVID-19 vaccine, with its short and long term effects, and possible correlations with peripheral nerve pathology. Conclusion. Neurological manifestation in COVID-19 may represent a challenge for the clinician, and with growing numbers of unprecedented cases of peripheral nerve pathology associated with the SARS-CoV-2 virus being reported, further research is urgently needed.
Clinical neurological characteristics of geriatric patients with COVID-19 in Sanglah General Hospital from 2020 to 2021
Authors:   Neurology Department, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia, Yolanda Adriana Marsha , Laksmidewi Anak Agung Ayu Putri ,   Neurology Department, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia, Meidiary Anak Agung Ayu ,   Neurology Department, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia
Published: April 2022

Background and objectives. COVID-19 is a respiratory infection caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2). The COVID-19 associates multi-clinical symptoms such as neurological manifestations with mild to advanced progression. This study aimed to determine the clinical neurological characteristics of geriatric patients with COVID-19. Methods. The study was an observational and descriptive study on 27 geriatric patients with COVID-19. All patients’ age was over 60 years old who treated in the in-patient department of Sanglah General Hospital, Denpasar on July 2020 to January 2021. The data were taken from medical records. Outcomes. The mean age of all patients was 70.41 (± 8.902) years, and dominated by the males (51.9%). The majority of manifestations in this study were fever in 13 people (48.1%), unconsciousness in 10 people (37%), hemiparesis in 10 people (37%) and cough in 9 people (33.3%). Conclusions. The clinical neurology characteristics of geriatric patients with COVID-19 vary, which may involve general and neurological manifestations. Promptly accurate diagnosis is necessary for further management.
The frequency of abnormal electroencephalography for detecting acute ischemic stroke
Authors:   Neurology, Dow University of Health Sciences, Karachi, Pakistan, Iltaf Samar , Pechuho Sahar-u-nisa ,   Neurology, Dow University of Health Sciences, Karachi, Pakistan
Published: April 2022

Introduction. Cerebrovascular accident is defined as rapidly developing symptoms or signs of focal and global loss of cerebral function lasting for 24 hours or more with no apparent cause other than that of vascular origin. Stroke is the fifth leading cause of death in the United States and it is one of the most disabling cause of neurological disorders. The attack of cerebrovascular accident begins abruptly, the focal neurologic deficit either fully evolved at the onset or it progress over minutes to hours or within days. Electroencephalogram (EEG) is used to detect electrical activity in the brain for various neurologic disorders like epilepsy, encephalopathy, prion diseases (CJD), Alzheimer disease and also stroke. Objective. To determine the frequency of abnormal EEG for detecting acute ischemic stroke. Methods. This was a cross sectional study conducted at Department of Medicine, Dow University of Health Sciences Karachi OJHA Campus, Dow International Medical College (DIMC), and Duration of study was 06 month from 1st October 2020 to 30th March 2021. Non-probability consecutive sampling technique was used. A total of 460 patients of acute ischemic stroke were included in this study. Patients were diagnosed on the basis of CT scan brain or diffusion weighted imaging. Within 24 hours the EEG was done in all admitted patients. The potentials recorded by EEG were cumulated excitatory and inhibitory postsynaptic potentials in neuronal dendrites, usually in most superficial regions of cerebral cortex. All data was entered and analyzed using SPSS v25.0. Data were stratified for age, gender, BMI and duration of stroke to address the effect modifiers. Post-stratification, Chi-square test was used by taking p-value ≤0.05 as significant. Results. 460 patients were selected for this study. Mean age was 40.04±9.1 years. Among cases, there were 276 (60%) males and 184 (40%) females. 235 patients (51.08%) had abnormal EEG. By stratification of abnormal EEG, it was found that duration of acute stroke had significant effect having abnormal EEG (p = 0.000001). Conclusions. The role of complexity of abnormal Electro Encephalogram is useful following acute ischemic stroke. The various parameters of EEG help to evaluate the large ischemic stroke.
Adults brain tumor in Cipto Mangunkusumo General Hospital: A descriptive epidemiology
Authors:   Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia, Aninditha Tiara
Published: April 2022

Background. Brain tumor is a rare tumor with low incidence. Although it is a rare tumor, the mortality of brain tumor is disproportionately high. Many countries have already published epidemiology of brain tumor. However, the epidemiology of brain tumor in Indonesia remains to be investigated. This article aimed to provide descriptive epidemiology of brain tumor. Methods. The data of brain tumor acquired from Department of Neurology and Neurosurgery Cipto Mangunkusumo General Hospital from 2014 to 2016. The histopathology classification of primary intracranial tumors was based on WHO classification of CNS tumors 2016 while brain metastasis was classified based on other histopathological types. The variables were analyzed and presented descriptively. Results. There were 316 subjects acquired in this study. Most of the subjects (68%) were women. The mean age of this study was 43.8 (11.7). Most of the subjects (86.1%) had primary histopathology. Lung cancer was the most commonly found brain metastasis in this study (34.1%). Conclusions. This is a pilot study of brain tumor epidemiology in Indonesia. Collaboration with other centers in Indonesia is needed to give a more representative insight of brain tumor in Indonesia.
Diagnostic biomarkers of multiple sclerosis
Authors:   Biotechnology Research Center and Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran, Asgharzadeh Mohammad , Valiallahzadeh Mir Reza ,   Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Taghinejad Zahra ,   Hematology & Oncology Research center, Tabriz University of Medical Sciences, Tabriz, Iran, Poor Behroz Mahdavi ,   Department of Laboratory Sciences, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran, Kafil Hossein Samadi ,   Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Asgharzadeh Vahid ,   Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran, Rashedi Jalil ,   Department of Laboratory Sciences, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran
Published: April 2022

Multiple sclerosis (MS) is a chronic and inflammatory disease of the central nervous system (CNS) that is common in people between the ages of 20 and 40. Although the exact cause of MS is still unknown, evidences shows that genetic and environmental factors have a role in activating immune cells to attack the myelin sheath of the neurons, and causing them to be damaged. In order to control and reduce the disease prevalence, early identification of at risk people and patients in the early stages of the disease is important. Measurement of interferon gamma (IFN-γ), vitamin D, melatonin, neurofilaments, micro RNA-132 (miR-132), miR-155, determination of antibody titer against Epstein-Barr virus (EBV) and human leukocyte antigen (HLA) typing are appropriate methods to diagnose the disease, and ultimately prevent its recurrence.
Distal oesophageal spasm as a manifestation of myasthenia gravis
Authors:   Department of Neurology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India, Karri Madhavi , Ramasamy Balakrishnan ,   Department of Neurology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India, Perumal Santhosh ,   Department of Neurology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India
Published: April 2022

Myasthenia gravis is an autoimmune neuromuscular junction disorder affecting skeletal muscles. It is characterized by muscle fatigability with fluctuating weakness and diurnal variations. Here, we present an elderly female presented with subacute onset dysphagia predominantly to solids with weight loss for one month. Upper gastrointestinal endoscopy showed a crico-esophageal spasm. Manometric studies showed distal esophageal spasm with normal pressures. Clinically, she had proximal muscle weakness of all four limbs with bulbar weakness. Nerve conduction studies done were suggestive of postsynaptic neuromuscular junction disorder. Serum acetylcholinesterase receptor antibodies were elevated. We started her on pyridostigmine and low dose steroids, following which her symptoms improved. Here smooth muscle involvement was considered secondary to myasthenia gravis, which recovered after treatment. Treating physicians should even think of neurological causes in patients presenting with dysphagia predominant to solids.
Herpes zoster following Streptococcus suis infection: A case report
Authors:   Department of Dermatovenerology, Faculty of Medicine, Udayana University, Sanglah General Hospital, Bali, Indonesia, Tirka Putu Shinta Widari , Puspawati Ni Made Dwi ,   Department of Dermatovenerology, Faculty of Medicine, Udayana University, Sanglah General Hospital, Bali, Indonesia, Sarongku Tommy ,   Department of Neurology, Faculty of Medicine, Udayana University, Sanglah General Hospital, Bali, Indonesia, Widyadharma I Putu Eka ,   Department of Neurology, Faculty of Medicine, Udayana University, Sanglah General Hospital, Bali, Indonesia
Published: April 2022

Background. Herpes zoster is a disease caused by reactivation of endogenous viruses that cause local dermatomal disorders characterized by unilateral radicular pain and vesicular dermatomal eruption. Some of the factors that responsible for reactivation of the herpes zoster virus are older age and low immune status. Case presentation. A 54-years-old presenting with meningitis after consumed a raw pork. Five days later developed herpes zoster. Conclusions. Herpes simplex reactivation in Streptococcus suis infection might relate to low immune system caused by the poor immune response to antibody and the use of high-dose systemic steroid.
Ischemic stroke as a comorbidity in a patient with Stanford A aortic dissection: A case report
Authors:   Department of Cardiology, Faculty of Medicine, Udayana University, Sanglah General Hospital, Bali, Indonesia, Adipermana Made Bagus , Wibhuti Ida Bagus Rangga ,   Department of Cardiology, Faculty of Medicine, Udayana University, Sanglah General Hospital, Bali, Indonesia, Saraswati Olivia ,   Department of Cardiology, Faculty of Medicine, Udayana University, Sanglah General Hospital, Bali, Indonesia, Sari Ni Made Ayu Wulan ,   Department of Cardiology, Faculty of Medicine, Udayana University, Sanglah General Hospital, Bali, Indonesia
Published: April 2022

Background. Aortic dissection is one of the leading causes of death in cardiovascular disease. The clinical course of aortic dissection is often atypical and can mimic a variety of clinical manifestations. Stroke is one of the conditions that can make the management of aortic dissection becoming more complex. Case presentation. A 55-year-old female patient came with complaints of severe chest pain. The patient was diagnosed with Stanford aortic dissection, De Bakey type II, hypertension heart disease, mild mitral regurgitation, mild circumferential pericardial effusion. After the second day of treatment, the patient also complained of sudden slurred speech and weakness on right extremities. The administration of antiplatelet were postponed in consideration of the current patient with aortic dissection. On the 7th day of treatment, the patient experienced a worsening motor strength on the right extremities. We decided to continue antihypertensive therapy on acute phase of ischemic stroke with the consideration that aortic dissection can cause higher mortality. Conclusions. The management of ischemic stroke in a patient with aortic dissection is challenging. In ischemic stroke patient with aortic dissection, anti-hypertensives need to be given to reduce the stress on the aortic wall and prevent expansion of the dissection which has a higher mortality rate.
Relationship between phosphatase and tensin homolog (PTEN) expression in high grade glioma and histopathologic findings
Authors:   Department of Pathology, Tehran University of Medical sciences, Tehran, Iran, Hayati Nasim , Tabriz Hedieh Moradi ,   Department of Pathology, Tehran University of Medical sciences, Tehran, Iran, Nazar Elham ,   Department of Pathology, Tehran University of Medical sciences, Tehran, Iran, Gorji Reza ,   Department of Neurology, Qazvin University of Medical sciences, Qazvin, Iran
Published: April 2022

Introduction. Malignant glioma is resistant brain tumor to treatment and considered by aggressiveness that fails successful resection. Molecular pathways including PTEN related with tumor behavior. Materials and methods. We studied the immunohistochemical expression of PTEN in 32 brain surgical resection specimens with different histologic grades. All samples were from pathology department of Sina hospital in Tehran-Iran from 2020-2021. Results. From 32 patients, 21 (65.6%) had no PTEN staining. There was significant relationship between high age and no PTEN expression and average age with no PTEN staining was 54.05±14.01 years (P value: 0.044). There was significant relationship between necrosis in histopathologic evaluation with no PTEN staining (P value: 0.016). Also, there was no significant relationship between sex, tumor’s size, Tumor’s site, tumor’s grade, and primary or secondary type of tumor with PTEN staining (P value > 0.05). Conclusion. PTEN expression related to histopathologic features such as necrosis and age. PTEN can be introduced as an important prognostic indicator in high grade.