bluuebunny/crossref_metadata_2025 huggingface dataset:
Online Advertising and Real Estate sales: evidence from the Housing Market
Authors: Zhang Xiuzhi , Zhang Ying , Lin Zhijie
Published: November 2022

Despite the popular use of online advertising by marketers, little is known about its role in the real estate market. This research aims to investigate how online advertising affects the sales of new houses and explores potential contingent factors and the underlying mechanism. Based on a rich secondary data set and econometric models, we find that online advertising increases the sales of new houses, and the effect is stronger with lower housing prices, higher residential incomes, and lower-tier cities. Additionally, the mechanism is that advertising generates an impact via processes, such as lowering housing prices, attracting more immigrants, and reducing emigration. Lastly, the spillover effect of online advertising may not exist in the housing market. We discuss theoretical contributions and important implications to practitioners and policy makers.
Siwa Oasis groundwater quality: factors controlling spatial and temporal changes
Authors: Elnazer Ahmed A. , Salman Salman A. , Mohamed Yasser M. A. , Stafford Jason , Davies Philip , El Nazer Hossam A.
Published: November 2022

Siwa Oasis is of great historical, environmental, and scientific importance, as it contains unique archeological and geological features. Groundwater is the main source of freshwater in that oasis. The carbonate aquifer groundwater, used for irrigation, was sampled to evaluate factors controlling quality changes spatially and temporally by applying hydrochemical and statistical analyses. The salinity of the aquifer varied spatially from 1367 to 8645 mg/l based on one hydrogeological condition, with the highest TDS (> 5432.5 mg/l, 25% of samples) at the central part of the study area. Temporally, the salinity changed slightly from 3754.3 mg/l (in 2014) to 4222.4 mg/l (in 2020). The cession of illegal wells, pumping control, and excavation of formed salts have a noticeable impact on salinity (mediate the increase in salinity) and ions. However, about 61% of the studied samples can be considered unsuitable for irrigation owing to salinity and can harm plant yield. The heavy metals studied (Fe, Mn, Cu, Pb), except Cd, were within the permissible limit for irrigation water. Finally, it is proposed to construct desalination stations to enhance water quality for irrigation in the study area and set up many companies for salt extraction.
Participation and performance characteristics in half-marathon run: a brief narrative review
Authors: Nikolaidis Pantelis Theodoros , Knechtle Beat
Published: November 2022

Half-marathon (HM) is a running sport of increasing popularity in both sexes and in all age groups worldwide during the last years. Many studies have examined several aspects of HM, such as performance and participation trends, sex and age differences, physiological correlates, and training; however, no comprehensive review has ever been contacted to summarize the recently accumulated knowledge. Therefore, the aim of the present study was to review all previous research in this sport, focusing on participation and performance aspects. It was shown that HM runners had similar anthropometric and physiological characteristics as full-marathon runners which should be attributed to the affinity of these two races in terms of metabolic demands. Performance in HM was related with superior scores in aerobic capacity (maximal oxygen uptake, anaerobic threshold and running economy) and training characteristics (sport experience, weekly distance, training speed, frequency of sessions and long single endurance run distance), and lower scores in adiposity-related scores (e.g. body mass, body mass index, body fat percentage and skinfold thickness). Considering the popularity of HM race and the lack of many original studies (compared to FM race), this is an exciting field for scientific research with a large potential for practical applications, since the majority of HM runners are amateur runners in need of sex-, age- and performance-tailored exercise prescription.
Exciting Storms: Weather Phenomena as Catalysts of Chivalric Adventures
Authors: Reich Philip
Published: November 2022

The tempest is a conventional figure in epic tradition. This essay examines the narrative position of weather phenomena in Middle High German courtly romances and their relation to the adventures of the active characters–most of them knights. In particular, storms, as severe meteorological perturbations, seem to excite heroic exploits as they mark the difference between the space of origin and a space of danger. To return to safety, the heroes undergo adventures, but also expose themselves to perilous situations in which they lose their agency. This (in some ways paradoxical) constellation between passivity and activity is processed through various narrative possibilities in which agency alternates between the prescient characters and meteorological ‘entities’. The essay is concerned mainly with theEneasRomance (Heinrich von Veldeke), the anonymousHerzog Ernst(B), and the Arthurian RomancesParzival(Wolfram von Eschenbach),Iwein(Hartmann von Aue) andDiuCrône(Heinrich von dem Türlin).
Decentring the discoverer: how AI helps us rethink scientific discovery
Authors: Clark Elinor , Khosrowi Donal
Published: November 2022

This paper investigates how intuitions about scientific discovery using artificial intelligence (AI) can be used to improve our understanding of scientific discovery more generally. Traditional accounts of discovery have been agent-centred: they place emphasis on identifying a specific agent who is responsible for conducting all, or at least the important part, of a discovery process. We argue that these accounts experience difficulties capturing scientific discovery involving AI and that similar issues arise for human discovery. We propose an alternative, collective-centred view as superior for understanding discovery, with and without AI. This view maintains that discovery is performed by a collective of agents and entities, each making contributions that differ in significance and character, and that attributing credit for discovery depends on various finer-grained properties of the contributions made. Detailing its conceptual resources, we argue that this view is considerably more compelling than its agent-centred alternative. Considering and responding to several theoretical and practical challenges, we point to concrete avenues for further developing the view we propose.
Investigation of Contact Clusters Between Rough Surfaces
Authors: Yin Shijun , Costagliola Gianluca , Molinari Jean-François
Published: November 2022

We investigate the persistence of micro-contacts between two elastic random rough surfaces by means of a simple model for quasi-static sliding. Contact clusters are calculated with the Boundary Element Method, then surfaces are repeatedly displaced to study the evolution of the original contact area. While the real contact area remains constant due to the rejuvenation of micro-contacts, the original contact clusters are progressively erased and replaced by new ones. We find an approximate exponential decrease of the original real contact area with a characteristic length that is influenced both by statistics of the contact cluster distribution and physical parameters. This study aims to shine light on the microscopic origins of phenomenological rate-and-state friction laws and the memory effects observed in frictional sliding.
The Evolutionary Origin(s) of the Umwelt
Authors: Tønnessen Morten
Published: November 2022

Although Jakob von Uexküll´s Umwelt theory is not mentioned in Jablonka and Ginsburg´s Target article, von Uexküll´s theory is clearly relevant in the context of the article, with the authors´ emphasis on the origin of “subjective experiencing”. I relate some of Jablonka and Ginsburg´s main claims to an evolutionary perspective on Umwelt theory. As it turns out, the Umwelt has multiple evolutionary origins depending on our exact definition(s) of Umwelt.
Pretreatment platelet-to-lymphocyte ratio (PLR) as a prognosticating indicator for gastric cancer patients receiving immunotherapy
Authors: Gou Miaomiao , Zhang Yong
Published: November 2022

Background

Previous investigations suggest that systemic inflammation markers are able to provide prognostic value in several cancers. This study seeks to characterize the ability of pretreatment platelet-to-lymphocyte ratio (PLR) to prognosticate advanced or metastatic gastric cancer patients (AGC or MGC, respectively) receiving immunotherapy.

Methods

AGC and MGC patients exposed to PD-1 inhibitors from January 2016–August 2021 in the Chinese PLA General Hospital were recruited. Correlations between PLR and overall survival (OS), progression-free survival (PFS), and immunotherapy-associated tumor response rates were determined.

Results

237 patients were enrolled for this retrospective investigation. The 6 month and 12 month PFS based on the area under the curve value was 0.60 and 0.65 (p < 0.05). based on a calculated PLR cut-off value of 139.41, The PLR < 139.41 group has a longer OS in contrast with the PLR ≥ 139.41 group (13.46 m vs 10.71 m, HR = 0.57, 95% CI 0.42–0.78, p = 0.004). The PLR < 139.41 group had a PFS of 7.93 m in contrast to the 4.75 m seen in those with PLR ≥ 139.41 group (HR = 0.57, 95% CI 0.43–0.76, p = 0.002). The disease control rate (DCR) and objective response rate (ORR) were 86.17% and 30.85%, respectively, in the PLR < 139.41 group, but were 82.52% and 32.17%, respectively in the PLR ≥ 139.41 group. Both groups did not show any marked differences in terms of ORR and DCR (p = 0.887, p = 0.476). PLR is an independent prognostic indicator for OS and PFS upon uni- and multivariate analyses (p < 0.05).

Conclusions

Pre-treatment PLR correlated significantly with PFS and OS in AGC and MGC patients who received immunotherapy. An elevated PLR may provide guidance on subsequent treatment options.
Envelope-based constrained model for multiparameter pre-stack seismic inversion
Authors: Shan Junzhen , Wu Guochen , Yang Sen , Liu Hongying
Published: November 2022

Pre-stack seismic inversion is an effective method to estimate multiparameter from seismic reflection data in the oil–gas reservoir exploration. In order to get a reliable inverted parameter result, a constrained model is commonly used to reduce the multi-solution in the seismic inversion. However, it is hard to get an appropriate constrained model by conventional well-log data interpolation or velocity field in offshore oil–gas exploration with sparse wells. Envelope inversion has been successfully applied to get a good initial model with low-frequency components in full-waveform inversion. In order to fully exploit the rich information contained in seismic data, we introduce envelope inversion into background modeling based on convolution theory and propose a multiparameter pre-stack seismic inversion with envelope prior constraint. Both inversion results of the model and field data indicate the effectiveness and adaptability of the proposed method in multiparameter estimation.
Social Media as Social Science Data
Authors: Wilson Steven Lloyd
Published: November 2022

Social media has put mass communication in the hands of normal people on an unprecedented scale, and has also given social scientists the tools necessary to listen to the voices of everyday people around the world. This book gives social scientists the skills necessary to leverage that opportunity, and transform social media's vast stream of information into social science data. The book combines the big data techniques of computer science with social science methodology. Intended as a text for advanced undergraduates, graduate students, and researchers in the social sciences, this book provides a methodological pathway for scholars who want to make use of this new and evolving source of data. It provides a framework for building one's own data collection and analysis infrastructure, a toolkit of content analysis, geographic analysis, and network analysis, and meditations on the ethical implications of social media data.
Food Insecurity and COVID-19 Food-Related Perceptions, Practices, and Problems: A 3-State Descriptive Study
Authors: Koyratty Nadia , Clay Lauren , Penta Samantha , Silver Amber
Published: November 2022

Objective:

To compare food insecurity (FI) risk and food-related COVID-19 infection risk perceptions, practices, and problems (3P) in Washington (WA), New York (NY), and Louisiana (LA).

Methods:

Data from the RAPID Multi-Wave Risk Perception Study was collected via online surveys between May 19 to July 14, 2020 (N = 1260). Multivariable - adjusted logistic and ordinal regressions were performed for odds of FI risk and 3P during these early months of the pandemic.

Results:

The determinants of FI risk in all states included income, age, and employment. Some determinants were state-specific: households with members at substantial risk for COVID-19 (WA and NY), ethnicity (NY), education, and relationship status (LA). The odds of FI risk were higher among those who perceived higher likelihood of COVID-19 infection via in-store shopping (OR = 1.34, 95% CI: 1.06, 1.70) and improperly cooked food (OR = 1.87, 95% CI: 1.46, 2.41). FI risk was associated with higher odds of problems related to food affordability (OR = 10.66, 95% CI: 7.87, 14.44), preference (OR = 2.51, 95% CI: 1.86, 3.39), sufficiency (OR = 2.63, 95% CI: 1.96, 3.54), food sources (OR = 7.68, 95% CI: 5.73, 10.31), food storage capacity (OR = 0.48, 95% CI: 0.36, 0.66), and knowing where to find help in obtaining food (OR= 7.68, 95% CI: 5.73, 10.31); most of which did not differ by state. No association was found between food insecurity risk and food-related practices.

Conclusion:

Better food preparedness is needed to reduce FI risk during pandemics in specific groups in WA, NY, and LA. Specifically, food affordability, sufficiency, and storage, as well as sources, and increasing knowledge on food programs are limitations that need to be addressed for emergency situations.
Pre-COVID-19 Physician Awareness of Mental Health Resources During and After Natural and Human-Made Disasters
Authors: Sood Natasha , Hazelton Joshua P. , Boehmer Sue , Olympia Robert P.
Published: November 2022

Objective:

Physician mental health is critical during the recovery of natural and human-made disasters (NHDs), yet the accessibility of mental health resources to physicians has not been characterized. This study examined emergency medicine and trauma physician knowledge of and access to mental health resources in NHD settings.

Methods:

The survey was electronically disseminated to the American College of Emergency Physicians and the American Association of the Surgery of Trauma between February 4, 2020, and March 9, 2020. The 17-question survey assessed physician awareness and access to emergency preparedness resources at their institutions.

Results:

Of the responders, 86% (n = 229) were aware of written emergency response plans for their facility. While 31% were aware of the hospital’s mental health policies and resources outside of the emergency response plan, only 25% knew how to access these resources during and after NHDs. Finally, 10% reported the incorporation of mental health resources during institutional practice drills.

Conclusions:

Physicians reported knowledge of emergency preparedness policies; however, significant gaps remain in physician knowledge and access to mental health resources NHD settings. As NHDs increase on a global scale, it is critical for health systems to ensure accessible infrastructure to support the mental well-being of health professionals.
Influencing Factors of Patients’ Trust in Nurses During the COVID-19 Pandemic: A Mixed-Methods Study
Authors: Tang Xiaolan , Lu Junhua , Chen Zhihui , Liu Chao , Jiang Xue , Ning Mei
Published: November 2022

Objective:

This study aimed to investigate the nurse-patient trust among in-patients in the context of the coronavirus disease (COVID-19) epidemic; it further analyzed the related influencing factors, which will provide a theoretical basis for developing corresponding measures.

Methods:

This study employed a mixed-method design and analyzed 149 patients at the Hongqi Hospital, affiliated with Mudanjiang Medical University, from December 2020 to February 2021. Quantitative analysis was carried out using the “Nurse Patient Trust Scale,” and qualitative analysis was performed using a semi-structured interview with in-patients.

Results:

The average score on the scale was 46.65 ± 2.83, and the scores of the 2 dimensions were: 23.24 ± 1.51 for ability and peace of mind, and 23.32 ± 1.53 for attitude and care. According to the interview data, the factors included 3 aspects: a comfortable hospital environment and humane management measures; the nurse’s own competence; and effective communication with patients.

Conclusion:

During the COVID-19 epidemic, there are still many factors affecting patients’ trust in nurses that can be addressed by taking different measures. All these factors must be considered by the relevant managers and clinical nursing staff to maintain a better nurse-patient trust relationship.
Resilient Nurses in the COVID-19 Compared With Non-COVID-19 Wards
Authors: Ghahramani Sulmaz , Bagheri Lankarani Kamran , Ahmadi Marzaleh Milad , Sayari Mohammad , Moradi Hekmatollah
Published: November 2022

Introduction:

Owing to daily exposure to high job stress, nurses need to use coping techniques. One of the coping strategies helping a person to cope with stressful situations effectively is resiliency skills. The aim of this cross-sectional study was to examine the factors related to nurses’ resiliency during the coronavirus disease 2019 (COVID-19) epidemic.

Methods:

The resiliency of 288 nurses, 145 nurses from the COVID-19 wards , and 143 nurses from other wards were compared using 25-item Connor & Davidson Resilience Questionnaire. This study was conducted in 2021 in four referral hospitals at Shiraz.

Results:

The mean age of participants was 32 y. The average resilience score in the in the participants worked in COVID-19 wards was 95.30 for men and 87.72 for women, and in the non-COVID-19 wards was 85.82 for men and 88.48 for women. The mean resiliency scores of nurses working in COVID-19 and non-COVID-19 wards did not show a statistically significant difference. Factors affecting resilience included age, employment status, gender, and job expectancy.

Conclusions:

In this study, the resiliency of nurses working in COVID-19 wards did not differed from that of working in non-COVID-19 ones. This result should be further investigated and elaborated. Health policymakers should consider job expectation, gender, age, and employment status of nurses when making plans for future pandemics.
A Precarious Future: Reflections from a Survey of Early Career Researchers in Archaeology
Authors: Brami Maxime , Emra Stephanie , Muller Antoine , Preda-Bălănică Bianca , Irvine Benjamin , Milić Bogdana , Malagó Aldo , Meheux Katie , Fernández-Götz Manuel
Published: November 2022

This article presents the results of a 2021 international online survey of 419 early career researchers in archaeology. Respondents were passionate about pursuing an academic career, but pessimistic about job and career prospects. Statistics highlight specific obstacles, especially for women, from unstable employment to inequitable practices, and a chronic lack of support. Over 180 open-ended comments reveal worrying levels of workplace bullying and discrimination, particularly targeting women and minorities. The impact of the COVID-19 pandemic on early career researchers is also examined. The survey's findings are analysed and contextualized within the international higher education sector. A communal effort is necessary to create sustained change, but early career researchers remain hopeful that change can be implemented.
Viscous effects on real gases in quasi-one-dimensional supersonic convergent divergent nozzle flows
Authors: Restrepo Julián , Simões-Moreira José R.
Published: November 2022

Viscous effects on an ideal gas flow in a supersonic convergent–divergent nozzle are a well-studied subject in classical gas dynamics. However, the ideal assumption fails on fluids that exhibit complex behaviours such as near-critical-region and non-ideal dense vapours. Under those conditions, a realistic equation of state (EOS) plays a vital role for a precise and realistic computation. This work examines the problem for solving the quasi-one-dimensional viscous compressible flow using a realistic EOS. The governing equations are discretised and solved using the fourth-order Runge–Kutta method coupled with a state-of-the-art EOS to calculate the thermodynamic properties. The role of the Grüneisen parameter along with viscous and real gas effects and their influence on the sonic point formation are discussed. The study shows that the flow may not achieve the supersonic regime for any pressure ratio depending on the combination of that parameter and the normalised friction factor. In addition, the analysis yields the discharge coefficient and the isentropic nozzle efficiency, which may achieve maximum values as a function of the stagnation conditions. Finally, the study also evaluates the formation and intensity of normal shock waves by using the Rankine–Hugoniot relations, which now depend on the real gas and viscous effects in opposition to the inviscid solution. Moreover, the methodology used captures the sonic point and shock wave position by a space marching algorithm using the Brent method for scalar minimisation. Experimental data available in the open literature corroborate the approach.
Urban transformation in the Central Medjerda Valley (north-west Tunisia) in late antiquity and the middle ages: a regional approach
Authors: Fenwick Corisande , Dufton Andrew , Ardeleanu Stefan , Chaouali Moheddine , Möller Heike , Pagels Julia , von Rummel Philipp
Published: November 2022

Recent scholarship on North African cities has done much to dispel earlier assumptions about late antique collapse and demonstrate significant continuity into the Byzantine and medieval periods. Yet urban changes did not affect North Africa evenly. Far less is known about the differing regional trajectories that shaped urban transformation and the extent to which pre-Roman and Roman micro-regions continued to share meaningful characteristics in subsequent periods. This article provides a preliminary exploration of regional change from the fourth to the eleventh century focused on a zone in the Central Medjerda Valley (Tunisia) containing the well-known sites of Bulla Regia and Chimtou. We place these towns in their wider historical and geographical setting and interrogate urban change by looking at investment in public buildings and spaces, religious buildings and housing, and ceramic networks. The process of comparison identifies new commonalities (and differences) between the sites of this stretch of the Medjerda River and provides a framework for understanding the many transformations of North African cities over the long late antiquity.
Relative validity of the online Meal-based Diet History Questionnaire for evaluating the overall diet quality and quality of each meal type in Japanese adults
Authors: Murakami Kentaro , Shinozaki Nana , Livingstone M. Barbara E. , Kimoto Nana , Masayasu Shizuko , Sasaki Satoshi
Published: November 2022

The aim of this study was to examine the relative validity of the online Meal-based Diet History Questionnaire (MDHQ) for assessing the overall diet quality and quality of each meal type (breakfast, lunch, dinner and snacks). In total, 222 Japanese adults (111 for each sex) aged 30–76 years completed the online MDHQ and then the 4-non-consecutive-day weighed dietary record (DR). The diet quality was assessed using the Healthy Eating Index-2015 (HEI-2015) and Nutrient-Rich Food Index 9.3 (NRF9.3). For the HEI-2015, compared with the DR, the MDHQ provided high median values for breakfast (in women only) and dinner and low median values for snacks. There were no significant differences observed for overall diet and lunch. For the NRF9.3, the MDHQ provided higher median values for breakfast and dinner and a lower median value for overall diet than the DR in women, with no significant differences for lunch and snacks. In men, no significant difference was observed, except for overall diet (the MDHQ providing a lower median value). For the HEI-2015, median Spearman correlation coefficient was 0·43, with a range from 0·12 (snacks in women) to 0·68 (breakfast in men). For the NRF9.3, median Spearman correlation coefficient was 0·47, with a range from 0·26 (snacks in men) to 0·65 (breakfast in men). Bland–Altman plots showed wide limits of agreement and, in some cases, proportional bias. In conclusion, the online MDHQ showed an acceptable ability for ranking individuals according to the quality of overall diet, breakfast, lunch and dinner, but not snacks.
Chirostyloid and galatheoid anomurans (Crustacea: Decapoda) from Indian waters, with descriptions of three new species
Authors: Tiwari Shivam , Padate Vinay P. , Cubelio Sherine Sonia , Osawa Masayuki
Published: November 2022

Seven species of chirostyloid and galatheoid crustaceans, including three new species, are reported from the eastern Arabian Sea and Bay of Bengal, India, based on material from depths ranging from 32–1420 metres.Trapezionida samudrikasp. nov. appears close toT. munin(Komai, 2011), but is distinguished by the shape of the carapace and fourth thoracic sternite, the armature of the third maxilliped merus, the length and armature of the cheliped, and the armature of the ambulatory legs.Paramunida travancoricasp. nov. differs from its closest speciesP. bineeshiMacpherson, Chan, Kumar & Rodriguez-Flores, 2020,P. mozambicaCabezas, Macpherson & Machordom, 2010, andP. stichasMacpherson, 1993 in the morphology of the carapace and antennular and antennal peduncles.Munidopsis bhavasagarasp. nov. is similar toM. dentifalxOsawa, Lin & Chan, 2007, but distinguishable by the absence of a pair of elevated, short ridges on the epigastric carapace region and the proportionally shorter chelipeds and ambulatory legs. The present material ofMunidopsis unguiferaAlcock & Anderson, 1894 represents only the third record of the species in India and a detailed description and illustrations are provided to supplement the previous descriptions. The remaining three species,Eumunida multispinaKomai, Chakraborty, Paramasivam & Gidda, 2019,Munidopsis scobinaAlcock, 1894, andM. stylirostrisWood-Mason in Wood-Mason & Alcock, 1891, are recorded from additional localities within their known geographic regions.
Association between physical activity status and severity of COVID-19 in older adults
Authors: Tsuzuki Shinya , Akiyama Takayuki , Matsunaga Nobuaki , Ohmagari Norio
Published: November 2022

The risk factors specific to the elderly population for severe coronavirus disease 2019 (COVID-19) caused by the Omicron variant of concern (VOC) are not yet clear. We performed an exploratory analysis using logistic regression to identify risk factors for severe COVID-19 illness among 4,868 older adults with a positive severe acute respiratory coronavirus 2 (SARS-CoV-2) test result who were admitted to a healthcare facility between 1 January 2022 and 16 May 2022. We then conducted one-to-one propensity score (PS) matching for three factors – dementia, admission from a long-term care facility and poor physical activity status – and used Fisher's exact test to compare the proportion of severe COVID-19 cases in the matched data. We also estimated the average treatment effect on treated (ATT) in each PS matching analysis. Of the 4,868 cases analysed, 1,380 were severe. Logistic regression analysis showed that age, male sex, cardiovascular disease, cerebrovascular disease, chronic lung disease, renal failure and/or dialysis, physician-diagnosed obesity, admission from a long-term care facility and poor physical activity status were risk factors for severe disease. Vaccination and dementia were identified as factors associated with non-severe illness. The ATT for dementia, admission from a long-term care facility and poor physical activity status was −0.04 (95% confidence interval −0.07 to −0.01), 0.09 (0.06 to 0.12) and 0.17 (0.14 to 0.19), respectively. Our results suggest that poor physical activity status and living in a long-term care facility have a substantial association with the risk of severe COVID-19 caused by the Omicron VOC, while dementia may be associated with non-severe illness.
Out-of-hours versus in-hours delivery of antenatally diagnosed transposition of the great arteries: outcomes from a United Kingdom Tertiary Centre
Authors: Cave Daniel G.W. , Lillitos Peter J. , Lancaster Rebecca , Bentham James R. , Barwick Shuba
Published: November 2022

Objective

To study the impact of out-of-hours delivery on outcome for neonates with antenatally diagnosed transposition of the great arteries.

Setting

Tertiary paediatric cardiology centre (Yorkshire, United Kingdom), with co-located tertiary neonatal unit.

Patients

Neonates with antenatally diagnosed simple transposition of the great arteries delivered out-of-hours (Monday to Friday 17:00–08:00 and weekends) versus in-hours between 2015 and 2020.

Outcome

The primary outcome was survival to hospital discharge. Secondary outcomes included neurological morbidity, length of stay, and time to balloon atrial septostomy.

Results

Of 51 neonates, 38 (75%) were delivered out-of-hours. All neonates born in the tertiary centre survived to discharge. Time to balloon atrial septostomy was slightly longer for out-of-hours deliveries compared to in-hours (median 130 versus 93 mins, p = 0.33). Neurological morbidity occurred for nine (24%) patients in the out-of-hours group and one (8%) in-hours (OR 3.72, 95% CI: 0.42–32.71, p = 0.24). Length of stay was also similar (18.5 versus 17.3 days, p = 0.59). Antenatal diagnosis of a restrictive atrial septum was associated with a lower initial pH (7.03 versus 7.13; CI: 0.03–0.17, p = 0.01), longer length of stay (22.6 versus 17.3 days; CI: 0.37–10.17, p = 0.04), and increased neurological morbidity (44% versus 14%; OR 4.80, CI 1.00–23.15, p = 0.05). A further three neonates were delivered in surrounding hospitals, with a mortality of 67% (versus 0 in tertiary centre; OR 172, CI 5-5371, p = 0.003).

Conclusion

Neonates with antenatally diagnosed transposition of the great arteries have similar outcomes when delivered out-of-hours versus in-hours. Antenatal diagnosis of restrictive atrial septum is a significant predictor of worse outcomes. In our region, delivery outside the tertiary cardiac centre had a significantly higher risk of mortality.
Health Emergency and Disaster Risk Management Workforce Development Strategies: Delphi Consensus Study
Authors: Hung Kevin K.C. , MacDermot Makiko K. , Chan Emily Y.Y. , Mashino Sonoe , Balsari Satchit , Ciottone Gregory R. , Della Corte Francesco , Dell’Aringa Marcelo F. , Egawa Shinichi , Evio Bettina D. , Hart Alexander , Ishii Tadashi , Ragazzoni Luca , Sasaki Hiroyuki , Walline Joseph Harold , Wong Chi S. , Dalal Saurabh , Kayano Ryoma , Abrahams Jonathan , Huda Qudsia , Graham Colin A.
Published: November 2022

Introduction:

Health workforce development is essential for achieving the goals of an effective health system, as well as establishing national Health Emergency and Disaster Risk Management (Health EDRM).

Study Objective:

The objective of this Delphi consensus study was to identify strategic recommendations for strengthening the workforce for Health EDRM in low- and middle-income countries (LMIC) and high-income countries (HIC).

Methods:

A total of 31 international experts were asked to rate the level of importance (one being strongly unimportant to seven being strongly important) for 46 statements that contain recommendations for strengthening the workforce for Health EDRM. The experts were divided into a LMIC group and an HIC group. There were three rounds of rating, and statements that did not reach consensus (SD ≥ 1.0) proceeded to the next round for further ranking.

Results:

In total, 44 statements from the LMIC group and 34 statements from the HIC group attained consensus and achieved high mean scores for importance (higher than five out of seven). The components of the World Health Organization (WHO) Health EDRM Framework with the highest number of recommendations were “Human Resources” (n = 15), “Planning and Coordination” (n = 7), and “Community Capacities for Health EDRM” (n = 6) in the LMIC group. “Policies, Strategies, and Legislation” (n = 7) and “Human Resources” (n = 7) were the components with the most recommendations for the HIC group.

Conclusion:

The expert panel provided a comprehensive list of important and actionable strategic recommendations on workforce development for Health EDRM.
Profiles of language and communication abilities in adolescents with fetal alcohol spectrum disorders
Authors: Poth Lauren D. , Love Tracy , Mattson Sarah N.
Published: November 2022

Objective:

Language and communication are largely understudied among youth with fetal alcohol spectrum disorders (FASD). Findings have been mixed, and have generally focused on more severely affected (i.e., children with FAS alone) or younger children. This study aimed to elucidate the profiles of language (i.e., receptive, expressive, general language) and communication (i.e., functional, social) abilities in adolescents with FASD.

Method:

Participants aged 12–17 years with (AE = 31) and without (CON = 29) prenatal alcohol exposure were included. Receptive and expressive language were measured by the Clinical Evaluation of Language Fundamentals – Fifth Edition (CELF-5). Parents or caregivers completed the Children’s Communication Checklist – Second Edition as a subjective measure of general language skills. Functional communication was measured by the Student Functional Assessment of Verbal Reasoning and Executive Strategies and parents or caregivers completed the Social Skills Improvement System Rating Scales as a measure of social communication. Multivariate analysis of variance determined the overall profiles of language and communication and whether they differed between groups.

Results:

The AE group performed significantly lower than the CON group on receptive language and parent report of general language while groups did not significantly differ on expressive language. Groups did not significantly differ on functional communication while social communication was significantly lower in the AE group.

Conclusions:

Results of this study provide important information regarding the overall profile of basic language abilities and higher-level communication skills of adolescents with FASD. Ultimately, improving communication skills of youth with FASD may translate to better overall functioning.
Quantifying spillovers of coordinated investment stimulus in the EU
Authors: Pfeiffer Philipp , Varga Janos , in ’t Veld Jan
Published: November 2022

In response to the recession brought about by the COVID-19 pandemic, EU-wide macroeconomic policy has launched an unprecedented coordinated fiscal expansion across the EU (Next Generation EU or NGEU), financed by issuing common debt. Given NGEU’s nature, it is essential to take fiscal spillovers into consideration when assessing the overall macroeconomic effects of this fiscal expansion. We quantify the effects of the additional public investment for all Member States in a rich macro-model with a trade structure. Our model suggests that, on average, GDP effects are around one-third larger when explicitly accounting for the spillover effects from individual-country measures. For small open economies with smaller NGEU allocations, spillover effects account for the bulk of the GDP impact. We also quantify key transmission channels.
Climate Warming Alters Nutrient Storage in Seasonally Dry Forests: Insights From a 2,300 m Elevation Gradient
Authors: Yang Yang , Berhe Asmeret Asefaw , Barnes Morgan E. , Moreland Kimber C. , Tian Zhiyuan , Kelly Anne E. , Bales Roger C. , O'Geen Anthony T. , Goulden Michael L. , Hartsough Peter , Hart Stephen C.
Published: November 2022

Understanding potential response of forest carbon (C) and nutrient storage to warming is important for climate mitigation policies. Unfortunately, those responses are difficult to predict in seasonally dry forests, in part, because ecosystem processes are highly sensitive to both changes in temperature and precipitation. We investigated how warming might alter stocks of C, nitrogen (N), and phosphorus (P) in vegetation and the entire regolith (soil + weathered bedrock or “saprock”) using a space‐for‐time substitution along a bioclimatic gradient in the Sierra Nevada, California. The pine‐oak and mixed‐conifer forests between 1,160–2,015 m elevation have more optimal climates (not too dry or hot) for ecosystem productivity, soil weathering, and cycling of essential elements than the oak savannah (405 m) and subalpine forest (2,700 m). We found decreases in overstory vegetation nutrient stocks with decreasing elevation because of enhanced water limitation and greater occurrence of disturbances. Stocks of C, N, and P in the entire regolith peaked at the pine‐oak and mixed‐conifer forests across the bioclimatic gradient, driven by thicker regolith profiles and greater nutrient input rates. These observations suggest long‐term warming will decrease ecosystem nutrient storage at the warmer, transitional pine‐oak zone, but will increase nutrient storage at the colder, subalpine zone. Assuming steady‐state conditions, we found the mean residence time of ecosystem C decreased with projected rising air temperatures and increased following a major drought event across the bioclimatic gradient. Our study emphasizes potentially elevation‐dependent changes in nutrient storage and C persistence with warming in seasonally dry forests.
Estuarine Salinity Response to Freshwater Pulses
Authors: Biemond Bouke , de Swart Huib E. , Dijkstra Henk A. , Díez‐Minguito Manuel
Published: November 2022

Freshwater pulses (during which river discharge is much higher than average) occur in many estuaries and strongly impact estuarine functioning. To gain insight into the estuarine salinity response to freshwater pulses, an idealized model is presented. With respect to earlier models on the spatiotemporal behavior of salinity in estuaries, it includes additional processes that provide a more detailed vertical structure of salinity. Simulation of an observed salinity response to a freshwater pulse in the Guadalquivir Estuary (Spain) shows that this is important to adequately simulate the salinity structure. The model is used to determine the dependency of the estuarine salinity response to freshwater pulses for different background discharge, tides, and different intensities and durations of the pulses. Results indicate that the change in salt intrusion length due to a freshwater pulse is proportional to the ratio between peak and background river discharge and depends linearly on the duration of the pulse if there is no equilibration during the pulse. The adjustment time, which is the time it takes for the estuary to reach equilibrium after an increase in river discharge, scales with the ratio of the change in salt intrusion length and the peak river discharge. The recovery time, that is, the time it takes for the estuary to reach equilibrium after a decrease in river discharge, does not depend on the amount of decrease in salt intrusion length caused by the pulse. The strength of the tides is of minor importance to the salt dynamics during and after the pulse.
Life Underground: Investigating Microbial Communities and Their Biomarkers in Mars‐Analog Lava Tubes at Craters of the Moon National Monument and Preserve
Authors: Weng M. M. , Zaikova E. , Millan M. , Williams A. J. , McAdam A. C. , Knudson C. A. , Fuqua S. R. , Wagner N. Y. , Craft K. , Kobs Nawotniak S. , Shields A. , Bevilacqua J. , Bai Y. , Hughes S. S. , Garry W. B. , Heldmann J. L. , Lim D. S. S. , Buckner D. , Gant P. , Johnson S. S.
Published: November 2022

Craters of the Moon National Monument and Preserve (CotM) is a strong terrestrial analog for lava tube formations on Mars. The commonality of its basalt composition to Martian lava tubes makes it especially useful for probing how interactions between water, rock, and life have developed over time, and what traces of these microbial communities may be detectable by current flight‐capable instrumentation. Our investigations found that secondary mineral deposits within these caves contain a range of underlying compositions that support diverse and active microbial communities. Examining the taxonomy, activity, and metabolic potential of these communities revealed largely heterotrophic life strategies supported by contributions from chemolithoautotrophs that facilitate key elemental cycles. Finally, traces of these microbial communities were detectable by flight‐capable pyrolysis and wet chemistry gas chromatography‐mass spectrometry methods comparable to those employed by the Sample Analysis at Mars (SAM) instrument aboard the Curiosity rover and the Mars Organic Molecule Analyzer (MOMA) on the upcoming Rosalind Franklin rover. Using a suite of methods for chemical derivatization of organic compounds is beneficial for resolving the greatest variety of biosignatures. Tetramethylammonium hydroxide (TMAH), for example, allowed for optimal resolution of long chain fatty acids. Taken together, these results have implications for the direction of mass spectrometry as a tool for biosignature detection on Mars, as well as informing the selection of sampling sites that could potentially host biosignatures.
Impacts of Heterogeneous Chemistry on Vertical Profiles of Martian Ozone
Authors: Brown M. A. J. , Patel M. R. , Lewis S. R. , Holmes J. A. , Sellers G. J. , Streeter P. M. , Bennaceur A. , Liuzzi G. , Villanueva G. L. , Vandaele A. C.
Published: November 2022

We show a positive vertical correlation between ozone and water ice using a vertical cross‐correlation analysis with observations from the ExoMars Trace Gas Orbiter's Nadir and Occultation for Mars Discovery instrument. This is particularly apparent during LS = 0°–180°, Mars Year 35 at high southern latitudes, when the water vapor abundance is low. Ozone and water vapor are anti‐correlated on Mars; Clancy et al. (2016, https://doi.org/10.1016/j.icarus.2015.11.016) also discuss the anti‐correlation between ozone and water ice. However, our simulations with gas‐phase‐only chemistry using a 1‐D model show that ozone concentration is not influenced by water ice. Heterogeneous chemistry has been proposed as a mechanism to explain the underprediction of ozone in global climate models (GCMs) through the removal of HOx. We find improving the heterogeneous chemical scheme by creating a separate tracer for the HOx adsorbed state, causes ozone abundance to increase when water ice is present (30–50 km), better matching observed trends. When water vapor abundance is high, there is no consistent vertical correlation between observed ozone and water ice and, in simulated scenarios, the heterogeneous chemistry has a minor influence on ozone. HOx, which are by‐products of water vapor, dominate ozone abundance, masking the effects of heterogeneous chemistry on ozone, and making adsorption of HOx have a negligible impact on ozone. This is consistent with gas‐phase‐only modeled ozone, showing good agreement with observations when water vapor is abundant. Overall, the inclusion of heterogeneous chemistry improves the ozone vertical structure in regions of low water vapor abundance, which may partially explain GCM ozone deficits.
A New Halocarbon Absorption Model Based on HITRAN Cross‐Section Data and New Estimates of Halocarbon Instantaneous Clear‐Sky Radiative Forcing
Authors: Buehler Stefan A. , Brath Manfred , Lemke Oliver , Hodnebrog Øivind , Pincus Robert , Eriksson Patrick , Gordon Iouli , Larsson Richard
Published: November 2022

The article describes a new practical model for the infrared absorption of chlorofluorocarbons and other gases with dense spectra, based on high‐resolution transmission molecular absorption database (HITRAN) absorption cross‐sections. The model is very simple, consisting of frequency‐dependent polynomial coefficients describing the pressure and temperature dependence of absorption. Currently it is implemented for the halocarbon species required by the Radiative Forcing Model Intercomparison Project. In cases where cross‐section data is available at a range of different temperatures and pressures, this approach offers practical advantages compared to previously available options, and is traceable, since the polynomial coefficients follow directly from the laboratory spectra. The new model is freely available and has several important applications, notably in remote sensing and in developing advanced radiation schemes for global circulation models that include halocarbon absorption. For demonstration, the model is applied to the problem of computing instantaneous clear‐sky halocarbon radiative efficiencies and present day radiative forcing. Results are in reasonable agreement with earlier assessments that were carried out with the less explicit Pinnock method, and thus broadly validate that method.
Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation
Authors: Tu Hailin , Xiong Weihang , Zhang Jie , Zhao Xueqiang , Lin Xin
Published: November 2022

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a cytosolic protein kinase that regulates multiple inflammatory and cell death pathways. Serine/Threonine phosphorylation of RIPK1 is known to suppress RIPK1 kinase-mediated cell death in the contexts of inflammation, infection and embryogenesis, however, regulation by tyrosine phosphorylation has not been reported. Here, we show that non-receptor tyrosine kinases Janus kinase 1 (JAK1) and SRC are able to phosphorylate RIPK1 at Y384 (Y383 in murine RIPK1), leading to suppression of TNF-induced cell death. Mice bearing a homozygous Ripk1 mutation that prevents tyrosine phosphorylation of RIPK1 (Ripk1Y383F/Y383F), develop systemic inflammation and emergency haematopoiesis. Mechanistically, Ripk1Y383F/Y383F mutation promotes RIPK1 kinase activation and enhances TNF-induced apoptosis and necroptosis, which is partially due to impaired recruitment and activation of MAP kinase-activated protein kinase 2 (MK2). The systemic inflammation and emergency haematopoiesis in Ripk1Y383F/Y383F mice are largely alleviated by RIPK1 kinase inhibition, and prevented by genomic deletions targeted to the upstream pathway (either to Tumor necrosis factor receptor 1 or RIPK3 and Caspase8 simultaneously). In summary, our results demonstrate that tyrosine phosphorylation of RIPK1 is critical for regulating RIPK1 activity to limit cell death and inflammation.
Self-healable printed magnetic field sensors using alternating magnetic fields
Authors: Xu Rui , Cañón Bermúdez Gilbert Santiago , Pylypovskyi Oleksandr V. , Volkov Oleksii M. , Oliveros Mata Eduardo Sergio , Zabila Yevhen , Illing Rico , Makushko Pavlo , Milkin Pavel , Ionov Leonid , Fassbender Jürgen , Makarov Denys
Published: November 2022

We employ alternating magnetic fields (AMF) to drive magnetic fillers actively and guide the formation and self-healing of percolation networks. Relying on AMF, we fabricate printable magnetoresistive sensors revealing an enhancement in sensitivity and figure of merit of more than one and two orders of magnitude relative to previous reports. These sensors display low noise, high resolution, and are readily processable using various printing techniques that can be applied to different substrates. The AMF-mediated self-healing has six characteristics: 100% performance recovery; repeatable healing over multiple cycles; room-temperature operation; healing in seconds; no need for manual reassembly; humidity insensitivity. It is found that the above advantages arise from the AMF-induced attraction of magnetic microparticles and the determinative oscillation that work synergistically to improve the quantity and quality of filler contacts. By virtue of these advantages, the AMF-mediated sensors are used in safety application, medical therapy, and human-machine interfaces for augmented reality.