bluuebunny/crossref_metadata_2025 huggingface dataset:
O USO DO DRY NEEDLING NA DISFUNÇÃO TEMPOROMANDIBULAR: UMA REVISÃO SISTEMÁTICA
Authors: Araújo João Victor de Jesus , Barbosa Jonathan Souza , Santos Raquel Bastos , Silva Graciely Lima Ferraz da
Published: October 2024

A Disfunção Temporomandibular (DTM) compreende um grupo de distúrbios que afetam as articulações temporomandibulares, músculos mastigatórios e estruturas associadas, manifestando-se principalmente por dor, limitação funcional e desconforto na região facial. A etiologia das DTMs é multifatorial, envolvendo aspectos biomecânicos, emocionais e psicossociais, com impacto significativo na qualidade de vida dos indivíduos afetados. Diversas abordagens terapêuticas têm sido adotadas para o tratamento da DTM, priorizando intervenções minimamente invasivas antes de considerar opções mais agressivas. Uma técnica de destaque é o Dry Needling (DN), que consiste na inserção de agulhas finas em pontos-gatilho miofasciais para promover relaxamento muscular e alívio da dor. Esta técnica tem sido cada vez mais utilizada devido à sua eficácia na redução da dor e melhora funcional em pacientes com DTM. O presente artigo tem como objetivo realizar uma revisão sistemática da literatura sobre o uso do Dry Needling como abordagem terapêutica para a DTM. A pesquisa foi conduzida nas bases de dados PubMed, LILACS e SciELO, considerando estudos publicados nos últimos cinco anos (2019-2024). Após a aplicação dos critérios de inclusão e exclusão, sete artigos foram selecionados para análise detalhada. Os resultados dos estudos revisados sugerem que o Dry Needling é eficaz na desativação dos pontos-gatilho, aliviando a dor muscular e promovendo relaxamento. Além disso, a técnica demonstrou efeitos positivos na funcionalidade da articulação temporomandibular e na qualidade de vida dos pacientes. Em comparação com outros métodos de tratamento, como fotobiomodulação e termoterapia, o DN mostrou eficácia superior na redução da dor desde a primeira sessão. Concluiu- se que o Dry Needling é uma intervenção promissora para o manejo da DTM, especialmente quando integrada a um plano terapêutico multidisciplinar que inclui fisioterapia, odontologia e suporte psicológico. Futuras pesquisas devem explorar combinações terapêuticas que potencializam os benefícios do DN, contribuindo para um tratamento mais abrangente e eficaz das DTMs.
La heteronomía fundamental del deseo humano según René Girard
Authors: Buil Unai
Published: October 2024

La teoría antropológica de René Girard postula que la característica básica del ser humano en contraposición al mundo animal del que deriva por evolución es el deseo. Entre la animalidad y la humanidad hay una diferencia de grado, no de esencia. Tal diferencia de intensidad se refiere específicamente a un elemento: la mímesis. Tanto animales como seres humanos son miméticos, pero los segundos lo son de modo particularmente destacado. Esa mímesis hiperbólica que caracteriza al hombre se convierte en ‘deseo’ que, de resultas, por definición, es deseo mimético. Las características esenciales de tal deseo emanan de la mímesis de la que surgen en el proceso de hominización al llegar a cierto umbral de intensidad. Entre ellas, la nota fundamental es la “heteronomía”, el objeto que deseamos lo anhelamos por el deseo de un tercero y no por las particularidades intrínsecas de ese “algo”. Es decir, nuestras tendencias sobre un objeto se refieren a él por la mediación desiderativa de un tercer individuo (un hombre semejante a nosotros), que se convierte en modelo de nuestros deseos. Queremos lo que queremos porque un tercero lo desea. Esta dinámica genera tensiones interindividuales y, por extensión, sociales; en consecuencia, la humanidad no hace más que decaer en la violencia desde el origen de los tiempos. En el fondo, el problema de base de la violencia humana es una cuestión mimética pero focalizada en concreto en la manera como se articula la mediación entre el deseo humano y la trascendencia divina.
Más allá de la Ilustración francesa: el humanismo polaco de Karol Wojtyla (2a Parte)
Authors: Gómez Nieves
Published: October 2024

Una vez convertido en profesor de la Cátedra de Ética en la Universidad de Lublin (Polonia), el joven Karol Wojty?a participará en el notable y ambicioso proyecto de reformulación de los ideales ilustrados, protagonizado por un núcleo de profesores de la Facultad de Filosofía, que veían en la Ilustración francesa un hito a superar, sobre todo por la necesidad de ir más allá de un tipo de razón deficitaria, que mostraba la imposibilidad de establecer un diálogo fecundo con otras áreas del saber. Este proyecto de formulación de un humanismo completo, sin amputaciones, es el que seguirá latiendo hasta el final de sus días, como se puede comprobar de manera muy explícita en su última obra, publicada un mes antes de su muerte, Memoria e identidad: conversaciones al filo de dos milenios (2005), la cual tiene una enorme profundidad filosófica y en cierta manera puede ser considerada como la herencia intelectual de un hombre que había vivido numerosas formas de despersonalización y quería ofrecer al mundo un modelo completo de humanismo, fruto de la experiencia colectiva de su patria.
Jacques Maritain y Simone Weil. Correspondencia amistosa y algunos desencuentros
Authors: Herrando Carmen
Published: October 2024

Jacques Maritain y Simone Weil se conocieron en Nueva York en julio de 1942; el encuentro fue breve, pero se prolongaría con un intercambio de cartas. Simone Weil estaba al corriente de la conversión al catolicismo de Maritain y de su esposa Raïssa, esta última de origen judío, y, a pesar de que Simone Weil no sentía atracción alguna por Aristóteles y el tomismo, Maritain era para ella un referente cristiano y moral; por eso le expondría por escrito su propia situación espiritual, la de alguien que se estaba acercando a la Iglesia católica, pero que aún no tenía luz suficiente sobre la conveniencia de bautizarse, y dudaba mucho si podría ser admitida en la Iglesia con sus planteamientos y sus preguntas. A este encuentro con Maritain seguirían, sin embargo, algunos desencuentros intelectuales, debidos a las diferentes concepciones que los dos pensadores tenían sobre el derecho y ante la noción de persona.
KETAKUTAN TOKOH DALAM MANGA BLEACH VOL. 1 KARYA TITE KUBO
Authors: Nurfadila Nikita , Andari Novi
Published: October 2024

Manga memiliki ciri khusus, terutama dalam teknik penggambaran karakter, yaitu penggambaran latar yang penuh dengan gambar dan tulisan untuk menekankan situasi cerita. Manga Bleach adalah manga karya Tite Kubo. Manga ini menceritakan tentang seorang tokoh bernama Ichigo Kurosaki. Dia adalah murid yang harus menggantikan Rukia Kuchiki, seorang Shinigami yang bertugas untuk membasmi Hollow yang menakuti karakter lain di manga Bleach. Penelitian ini menggunakan metode deskriptif kualitatif dengan pendekatan psikolinguistik. Penelitian ini menghasilkan temuan sebagai berikut; faktor penyebab ketakutan dalam manga Bleach volume 1 terdiri dari: 1) ancaman bahaya (39 data); 2) khawatir disakiti oleh seseorang (15 data); 3) situasi asing (29 data); 4) ketakutan akan peristiwa interpersonal (25 data); 5) ketakutan karena masalah eksistensial (38 data); 6) takut binatang (4 data); dan 7) ketakutan berhubungan dengan tempat (1 datum).
THE BASICS OF THE PHYSICO-CHEMICAL TECHNOLOGY OF OBTAINING SIMPLE PHOSPHORUS FERTILIZERS
Authors: Kudiyarova Ayimxan , Nurmurodov Tulkin
Published: October 2024

The article examines the basics of the physico-chemical technology of obtaining simple phosphorus fertilizers from aznekic phosphorites, which is becoming more and more relevant in the context of the growing demand for phosphorus for agriculture. The chemical composition and mineralogy of aznekic phosphorites, as well as their role in the production of phosphorus fertilizers, are discussed. We analyze the main stages of the technological process, including the preparation, extraction and conversion of raw materials into phosphorus compounds. The available methods of obtaining phosphoric acid and phosphoric fertilizers such as superphosphate and ammophos are highlighted, as well as the economic and ecological aspects of the use of aznekic phosphorites in agronomy are considered. At the end of the article, it is emphasized the need to continue research and development of new technologies that will increase the stability of agriculture and increase the efficiency of resource use.
CONCESSÃO DE BENEFÍCIOS FISCAIS PELO ERJ
Authors: Correa Jeferson Luís Terroso , Araújo Nina Quintanilha
Published: October 2024

O artigo destaca as principais deficiências de controle da política de concessão de benefícios fiscais do ERJ, a partir da consolidação dos achados das auditorias mais recentes realizadas pela Coordenadoria de Controle da Receita do TCE-RJ. As auditorias demonstram que há uma falta de controle estrutural, uma vez que as falhas perpassam várias gestões e setores das diferentes secretarias envolvidas na concessão e monitoramento dos benefícios fiscais, além de apresentar graves falhas de concepção, operacionalização e apuração de resultados. Em um cenário de deterioração das finanças estaduais, a discussão sobre a continuidade dessas políticas de incentivo, seu custo e retorno para a sociedade, adquire ainda mais importância, em especial diante da ausência de dados concretos e da constatação de que são desvinculadas de uma diretriz de política de desenvolvimento setorial ou regional que as justifique, destacandose ainda que o ERJ, desde 2017, está submetido às regras do Regime de Recuperação Fiscal, tendo que adotar medidas para aumentar receitas e reduzir despesas, com impactos severos sobre a quantidade e qualidade dos serviços públicos prestados à população.
OS ÓRGÃOS DE CONTROLE DIANTE DOS DESAFIOS DA SOCIEDADE DO CONHECIMENTO E DA TECNOLOGIA DIGITAL
Authors: Cavalcanti Marcos
Published: October 2024

Vivemos na sociedade do conhecimento, numa economia cada vez mais digitalizada e num ambiente onde a tecnologia está presente no dia a dia de milhões de pessoas, mas com um mindset dos séculos XIX e XX, da sociedade industrial. Essa distância entre realidade e imaginário faz as pessoas terem a sensação de que as instituições que temos não conseguem mais dar conta de suas obrigações e precisam ser transformadas. Este artigo foca os desafios com que se deparam os órgãos de controle (Tribunais de Contas, Controladoria-Geral e Ministério Público) diante dessa nova realidade intensiva em conhecimento e tecnologia digital. O argumento principal é que estamos diante de um processo de transformação social irreversível e que essas instituições precisam urgentemente rever seus processos, cultura e competências para fazer frente a esses desafios e poderem cumprir sua missão constitucional, sob pena de se tornarem ineficazes e serem percebidas como inúteis pela sociedade.
O ARTIGO 26 DA LINDBCOMO INSTRUMENTO DENEGOCIAÇÃO DE DÍVIDASE A ORDEM CRONOLÓGICADOS PAGAMENTOS NA ADMINISTRAÇÃO PÚBLICA
Authors: Santos Gustavo Silva Gusmão dos
Published: October 2024

O presente artigo tem como objetivo analisar o compromisso previsto no artigo 26 da Lei de Introdução às Normas de Direito Brasileiro como instrumento de composição aplicável à negociação de dívidas da Administração Pública junto a fornecedores de bens e prestadores de obras e serviços. Através de pesquisa bibliográfica, notadamente da legislação de regência e do estudo comparado da doutrina de direito administrativo, além da jurisprudência dos tribunais sobre o tema, conclui-se que o compromisso se revela como ferramenta de eficiência na gestão dos recursos públicos, permitindo a negociação de dívidas da Administração Pública, sem prejuízo à ordem cronológica dos pagamentos da Administração Pública.
Computing Hive Plots: A Combinatorial Framework
Authors: Nöllenburg Martin , Wallinger Markus
Published: October 2024

Hive plots are a graph visualization style placing vertices on a set of radial axes emanating from a common center and drawing edges as smooth curves connecting their respective endpoints. In previous work on hive plots, assignment to an axis and vertex positions on each axis were determined based on selected vertex attributes and the order of axes was prespecified.
Here, we present a new framework focusing on combinatorial aspects of these drawings to extend the original hive plot idea and optimize visual properties such as the total edge length and the number of edge crossings in the resulting hive plots.
Our framework comprises three steps: (1) partition the vertices into multiple groups, each corresponding to an axis of the hive plot; (2) optimize the cyclic axis order to bring more strongly connected groups near each other; (3) optimize the vertex ordering on each axis to minimize edge crossings.
Each of the three steps is related to a well-studied, but NP-complete computational problem.
We combine and adapt suitable exact and heuristic algorithmic approaches, implement them as an instantiation of our framework, and show in a case study how it can be applied in a practical setting. Furthermore, we conduct computational experiments to gain further insights regarding the algorithmic choices of our framework. The code of the implementation and a prototype web application can be found on OSF.
Giovanissimi colpevoli?
Authors: Carbone Mariateresa
Published: October 2024

In che misura l’impubere è tenuto a rispondere per il compimento di fatti illeciti? Si tratta di un interrogativo che si pone spesso nella riflessione giuridica attuale, ma che si presenta in termini per certi versi simili anche in epoca antica, caratterizzandosi oggi come allora per profili di grande problematicità. Da un soggetto in crescita l’ordinamento pretende infatti gradi sempre crescenti di consapevolezza nell’agire, valutando diversamente, dalla nascita alla pubertà, l’atteggiarsi della volontà ai fini dell’imputazione dell’illecito al suo autore, e ciò anche in ragione della natura del reato commesso. Attraverso l’esame delle fonti, non particolarmente numerose in argomento, ci si propone di offrire un quadro evolutivo delle regole e dei principi che, nel periodo che va dall’epoca arcaica a quella tardoclassica, disciplinano l’imputabilità del soggetto che non abbia ancora raggiunto la pubertà.
Analysis of quantum properties of two-mode coupled harmonic oscillator based on entangled state representation
Authors: Chen Feng , Ren Gang ,   Institute of Advanced Manufacturing Engineering, Hefei University, Hefei 230022, China,   School of Electronic Engineering, Huainan Normal University, Huainan 232001, China
Published: October 2024

The quantum oscillator model plays a significant role in quantum optics and quantum information and has been one of the hot topics in related research fields. Inspired by the single-mode linear harmonic oscillator and the two-mode entangled state representation, we construct a two-mode coupled harmonic oscillator in this work. Different from the quantum transformation method used in previous literature, the entangled state representation is directly used in this work to solve its energy eigenvalues and eigenfunctions easily. The energy eigenvalues and eigenfunctions of this two-mode coupled harmonic oscillator are continuous compared with those of the one-mode harmonic oscillator.

Using the matrix theory of quantum operators, we derive the transformation and inverse transformation of the time evolution operator corresponding to the two-mode coupled harmonic oscillator. In addition, using the entangled state representation, the specific form of the time evolution of the two-mode vacuum state under the action of the oscillator is obtained. Through the analysis of quantum fidelity, it is found that the fidelity of the output quantum state decreases with the oscillator frequency increasing, and the fidelity eventually tends to zero with the increase of time.

When analyzing the orthogonal squeezing properties of the output quantum state, this type of two-mode oscillator does not have the orthogonal squeezing effect, but it has a strong quantum dissipation effect instead. This conclusion is further verified by the quasi-probability distribution Q function of the quantum state phase space. Therefore, the two-mode coupled harmonic oscillator has a major reference value in quantum control such as quantum decoherence and quantum information transmission.

Like the two-mode squeezed vacuum state, the photon distribution of the output quantum light field corresponding to the two-mode harmonic oscillator presents a super-Poisson distribution, and the photons exhibit a strong anti-bunching effect. Using the three-dimensional discrete plot of the photon number distribution, the super-Poisson distribution and quantum dissipation effect of the output quantum state are intuitively demonstrated.

Finally, the SV, which is an entanglement criterion, is used to determine that the output quantum state has a high degree of entanglement. Further numerical analysis shows that the degree of entanglement increases with the action time and the oscillator frequency.

In summary, the two-mode coupled harmonic oscillator constructed in this work can be used to prepare highly entangled quantum states through a complete quantum dissipation process. This provides theoretical support for experimental preparing quantum entangled states based on dissipative mechanisms.
Incompatible Elements (REE, Th, U, Nb, Ta, Ti) Mineral Association in Altered Pegmatite from the Djurkovo Pb-Zn Deposit, Central Rhodopes: Occurrence and Geochemical Properties
Authors: Georgieva Sylvina , Vassileva Rossitsa , Grozdev Valentin , Milenkov Georgi , Cempírek Jan , Škoda Radek , Stefanova Elitsa
Published: October 2024

The Djurkovo base-metal vein deposit in Laki ore field, is hosted by a heterogeneous gneiss/amphibolite/marble rock sequence of the high-grade metamorphic complex of the Central Rhodopes. Mineralogical and geochemical investigation was conducted on slightly deformed, and hydrothermally altered thin pegmatite dykes intruded in the marbles. The pegmatite bodies consist mostly of K-feldspar, albite and quartz, with minor garnet present. Clear textural zonation within the bodies is absent except for the preferential crystallization of garnet in the innermost parts. The main pegmatite accessories include ishikawaite, zircon, apatite, monazite-(Ce), allanite-(Ce), and titanite. The post-magmatic hydrothermal overprint on the pegmatites resulted in the formation of the assemblage including epidote, sericite, chlorite, carbonate, quartz, hematite, and leucoxene. The accessory oxide, silicate, and phosphate minerals bearing rare earth elements (REE), actinides (ACT), Nb, Ta, and Ti have undergone partial replacement by secondary mineral phases (thortveitite, fergusonite, fersmite, uraninite, thorianite, REE-epidote, xenotime) observed as irregular grains or veinlets along fractures and dissolved zones, either inside or near the primary minerals.
Statistical learning beyond words in human neonates
Authors: Fló Ana , Benjamin Lucas , Palu Marie , Dehaene-Lambertz Ghislaine
Published: October 2024

Interest in statistical learning in developmental studies stems from the observation that 8-month-olds were able to extract words from a monotone speech stream solely using the transition probabilities (TP) between syllables (Saffran et al., 1996). A simple mechanism was thus part of the human infant’s toolbox for discovering regularities in language. Since this seminal study, observations on statistical learning capabilities have multiplied across domains and species, challenging the hypothesis of a dedicated mechanism for language acquisition. Here, we leverage the two dimensions conveyed by speech –speaker identity and phonemes– to examine (1) whether neonates can compute TPs on one dimension despite irrelevant variation on the other and (2) whether the linguistic dimension enjoys an advantage over the voice dimension. In two experiments, we exposed neonates to artificial speech streams constructed by concatenating syllables while recording EEG. The sequence had a statistical structure based either on the phonetic content, while the voices varied randomly (Experiment 1) or on voices with random phonetic content (Experiment 2). After familiarisation, neonates heard isolated duplets adhering, or not, to the structure they were familiarised with. In both experiments, we observed neural entrainment at the frequency of the regularity and distinct Event-Related Potentials (ERP) to correct and incorrect duplets, highlighting the universality of statistical learning mechanisms and suggesting it operates on virtually any dimension the input is factorised. However, only linguistic duplets elicited a specific ERP component, potentially an N400 precursor, suggesting a lexical stage triggered by phonetic regularities already at birth. These results show that, from birth, multiple input regularities can be processed in parallel and feed different higher-order networks.
Statistical learning beyond words in human neonates
Authors: Fló Ana , Benjamin Lucas , Palu Marie , Dehaene-Lambertz Ghislaine
Published: October 2024

Interest in statistical learning in developmental studies stems from the observation that 8-month-olds were able to extract words from a monotone speech stream solely using the transition probabilities (TP) between syllables (Saffran et al., 1996). A simple mechanism was thus part of the human infant’s toolbox for discovering regularities in language. Since this seminal study, observations on statistical learning capabilities have multiplied across domains and species, challenging the hypothesis of a dedicated mechanism for language acquisition. Here, we leverage the two dimensions conveyed by speech –speaker identity and phonemes– to examine (1) whether neonates can compute TPs on one dimension despite irrelevant variation on the other and (2) whether the linguistic dimension enjoys an advantage over the voice dimension. In two experiments, we exposed neonates to artificial speech streams constructed by concatenating syllables while recording EEG. The sequence had a statistical structure based either on the phonetic content, while the voices varied randomly (Experiment 1) or on voices with random phonetic content (Experiment 2). After familiarisation, neonates heard isolated duplets adhering, or not, to the structure they were familiarised with. In both experiments, we observed neural entrainment at the frequency of the regularity and distinct Event-Related Potentials (ERP) to correct and incorrect duplets, highlighting the universality of statistical learning mechanisms and suggesting it operates on virtually any dimension the input is factorised. However, only linguistic duplets elicited a specific ERP component consistent with an N400, suggesting a lexical stage triggered by phonetic regularities already at birth. These results show that, from birth, multiple input regularities can be processed in parallel and feed different higher-order networks.
DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci
Authors: Liu Yuzhen , McGann Christopher D , Krebs Mary , Perkins Thomas A , Fields Rose , Camplisson Conor K , Nwizugbo David Z , Hsu Chris , Avanessian Shayan C , Tsue Ashley F , Kania Evan E , Shechner David M , Beliveau Brian J , Schweppe Devin K
Published: October 2024

The accuracy of crucial nuclear processes such as transcription, replication, and repair, depends on the local composition of chromatin and the regulatory proteins that reside there. Understanding these DNA-protein interactions at the level of specific genomic loci has remained challenging due to technical limitations. Here, we introduce a method termed “DNA O-MAP”, which uses programmable peroxidase-conjugated oligonucleotide probes to biotinylate nearby proteins. We show that DNA O-MAP can be coupled with sample multiplexed quantitative proteomics and next-generation sequencing to quantify DNA-protein and DNA-DNA interactions at specific genomic loci.
Linking the evolution of two prefrontal brain regions to social and foraging challenges in primates
Authors: Bouret Sebastien , Paradis Emmanuel , Prat Sandrine , Castro Laurie , Perez Pauline , Gilissen Emmanuel , Garcia Cecile
Published: October 2024

The diversity of cognitive skills across primates remains both a fascinating and a controversial issue. Recent comparative studies provided conflicting results regarding the contribution of social vs ecological constraints to the evolution of cognition. Here, we used an interdisciplinary approach combining comparative cognitive neurosciences and behavioral ecology. Using brain imaging data from 16 primate species, we measured the size of two prefrontal brain regions, the frontal pole (FP) and the dorso-lateral prefrontal cortex (DLPFC), respectively, involved in metacognition and working memory, and examined their relation to a combination of socio-ecological variables. The size of these prefrontal regions, as well as the whole brain, was best explained by three variables: body mass, daily traveled distance (an index of ecological constraints), and population density (an index of social constraints). The strong influence of ecological constraints on FP and DLPFC volumes suggests that both metacognition and working memory are critical for foraging in primates. Interestingly, FP volume was much more sensitive to social constraints than DLPFC volume, in line with laboratory studies showing an implication of FP in complex social interactions. Thus, our data highlights the relative weight of social vs ecological constraints on the evolution of specific prefrontal brain regions and their associated cognitive operations in primates.
Reliability and validity of My Jump 2® app to measure the vertical jump in visually impaired five-a-side soccer athletes
Authors: Silva Julio Cesar , Silva Kalinne Fernandes , Torres Vitor Bruno , Cirilo-Sousa Maria Socorro , Medeiros Alexandre Igor Araripe , Esmeraldo Melo Jacques Eanes , Batista Gilmário Ricarte
Published: October 2024

Background

Although My Jump 2® consistently presented excellent values of reliability and validity when compared to force platforms (FPs) and contact mats, to date no scientific investigation assessed the validity and reliability of My Jump 2® to measure jump height in visually impaired five-a-side soccer athletes. Thus, the study aimed at analyzing the validity and reliability of the My Jump 2® to measure the vertical jump of five-a-side soccer athletes.

Methods

Twelve visually impaired five-a-side soccer athletes, volunteered for this study. Each player performed five countermovement jumps (CMJs) and squat jumps (SJs) on a contact platform (CP) while they were simultaneously recorded using My Jump 2®.

Results

There was almost perfect agreement between the My Jump 2® and the contact platform measurements of CMJ (intraclass correlation coefficient = 0.99; p < 0.001) and SJ (intraclass correlation coefficient = 0.99; p < 0.001), heights for athletes during the first and second measurement days. Bland-Altman analysis showed a bias of 0.25 ± 0.5 cm; maximum SD = 1.3; minimum SD = −0.88 for CMJ, while that Bland-Altman analysis showed bias 0.18 ± 0.5 cm; maximum SD = 1.3; minimum SD = −0.96, for SJ.

Conclusion

We can conclude that the My Jump 2® is a valid and reliable method to measure CMJ and SJ in visually impaired five-a-side soccer athletes.
Forkhead box D subfamily genes in colorectal cancer: potential biomarkers and therapeutic targets
Authors: Chen Ying , Qiao Haiyan , Zhong Ruiqi , Sun Lei , Shang Bingbing
Published: October 2024

Background

The forkhead box (FOX) family members regulate gene transcription and expression. FOX family members regulate various biological processes, such as cell proliferation and tumorigenesis. FOXD, a FOX protein subfamily, is associated with poor prognosis for various cancers. However, the potential clinical value of FOXD subfamily members in colorectal cancer (CRC) has not yet been elucidated. Therefore, in this study, we aimed to determine the role of the FOXD subfamily members in CRC development.

Methods

Using HTSeq-count data, clinical data, and single-nucleotide polymorphisms (obtained from The Cancer Genome Atlas Project), and bioinformatics analyses (using DESEQ2 software), we identified differentially expressed genes (DEGs) in CRC. Next, each DEG expression was validated in vitro using reverse transcription-quantitative polymerase chain reaction, western blotting, and immunohistochemistry (IHC).

Results

Among the FOXD subfamily members, the area under the receiver operating characteristic curve of FOXD3 was 0.949, indicating that FOXD3 has a high overall diagnostic accuracy for CRC. Gene Set Enrichment Analysis revealed that FOXD-DEGs were mainly related to pathways such as cytokine, cytokine, and extracellular matrix receptor interactions. Kaplan–Meier curves and nomograms showed that FOXD1, FOXD3, and FOXD4 were prognostically significant. In conclusion, FOXD subfamily members (especially FOXD3) could serve as diagnostic and prognostic biomarkers for CRC and an immunotherapy target in patients with CRC.
A Novel Improved Butterfly Optimization Algorithm Based on the Adaptive Inertia Weight and the Dynamic Switching Probability
Authors: Han Xiang
Published: October 2024

Butterfly optimization algorithm (BOA) is widely applied in various complex problems because of its efficient performance. However, similar to other swarm intelligent optimization algorithms, the BOA also has the problem of easily falling into the local optimum. In order to solve the above problem, this paper proposes an improved BOA (IBOA) by balancing local search and global search. In the IBOA, the adaptive inertia weight and the dynamic switching probability are introduced, which enables the IBOA to significantly improve the exploration ability in the early stage and the exploitation ability in the later stage, so that the algorithm is able to effectively escape from the local optimum. The performance of the IBOA is verified on eight benchmark functions. Compared with the other four optimization algorithms, the IBOA has the strongest optimization ability. Finally, a new prediction model is proposed based on that the IBOA is used to determine the hyper-parameters of support vector machine (SVM), which is called the IBOA-SVM model. Prediction experiments are carried out in earthquake magnitude dataset and air quality index dataset to validate the performance of the IBOA-SVM. The comparative experimental results indicate that, in comparison to the SVM, GWO-SVM, PSO-SVM, and BOA-SVM model, the values of MSE and MAE obtained by the IBOA-SVM model are the smallest, so our proposed model has higher prediction accuracy.
Analysis Of Blast Resistant Structure
Authors: Kulkarni Sirish S , Chitnis Sameer
Published: October 2024

The response of reinforced concrete buildings subjected to blast loading under variable mass of TNT and different statical system will be discussed. The study was carried out using the finite element program (ABAQUS) by using solid slab model. The plastic behavior of steel reinforced bars and concrete has been incorporated. The results obtained from the two models are in terms of Von-Mises stresses, deflection and concrete damage against varying mass of TNT. The results indicate that using double reinforced mesh has great influence on reinforced concrete slabs to withstand blast loads and the damage in concrete happened under blast loads in solid slab system. The response of reinforced concrete buildings subjected to blast loading under variable mass of TNT and different statical system will be discussed. The study was carried out using the finite element program (ABAQUS) by using Solid slab system. The plastic behaviour of steel reinforced bars and concrete has been incorporated. The results obtained for stresses, deflection and concrete damage against varying mass of TNT
Optimizing Sustainable Urban Mobility: Integration Of Electric Vehicle Charging Infrastructure Into Smart Buildings
Authors: Joseph. Ph.D Zosu Segbenu , Anosike Ph.D Amaghionyeodiwe Cyril , Adegboyega Ph.D Bilau, Abdulquadri
Published: October 2024

The integration of electric vehicle (EV) charging infrastructure into smart buildings is a crucial step toward enhancing sustainable urban mobility. This paper explores the benefits, challenges, strategies, and best practices associated with this integration, with a focus on optimizing EV charging accessibility and promoting a cleaner transportation ecosystem. Traditional vehicles powered by fossil fuels contribute significantly to pollution and greenhouse gas emissions, highlighting the urgent need for sustainable alternatives. EVs offer reduced emissions, lower operating costs, and potential energy independence through renewable sources, making them a promising solution for urban mobility challenges. Despite these advantages, the widespread adoption of EVs faces hurdles, particularly regarding charging infrastructure availability and accessibility in urban areas. Range anxiety among EV users due to insufficient charging stations is a significant concern hindering the transition to electric transportation. The paper emphasizes strategic placement of charging stations, integration with renewable energy sources like solar panels, and utilization of smart grid technologies to optimize EV charging operations. Case studies such as Tesla Gigafactory Shanghai and Googleplex showcase successful implementations, demonstrating scalability, user-centric design, and seamless integration with building management systems. Key challenges such as funding constraints, technical interoperability, and grid integration are addressed, proposing solutions like innovative financing models, standardization efforts, and advanced grid management technologies. By addressing these challenges and implementing sustainable solutions, the integration of EV charging infrastructure into smart buildings can significantly contribute to reducing environmental impact, promoting cleaner transportation options, and fostering a more sustainable and resilient urban environment
A Mini Review Of Modern Composites For Advanced Applications
Authors: Bhat Sunil
Published: October 2024

The field and scope of composites is constantly widening with the introduction of new materials and manufacturing technologies. Unknown properties of different engineering, non-engineering and bio-materials are regularly explored for the development of modern composites that show immense potential in future for applications in domestic, automotive, defence and aerospace industries. Some fundamental aspects, processing techniques, properties and applications of such composites are reviewed in the paper
Optimization Of Process Parameters For Incremental Forming Of Aluminium 1060
Authors: Chandrakanth A. , Krishnaiah Dr. A.
Published: October 2024

In the past two decades, extensive research was done on incremental sheet forming (ISF). It has resulted in significant advances in fundamental understanding and the development of new processing and tooling solutions. However, ISF is yet to be fully implemented in mainstream high-value manufacturing industries due to a number of technical challenges, all of which are directly related to ISF process parameters. Now a days, the demand for new materials for sheet plate has become high in the number of applications because of various attributes in the material such as high tensile strength, good flexibility and durability. The present work gives the effect of several process parameters such as tool rotating speed, step size(z-axis), and feed (x-y axis) on forming force of incremental forming. Particular attention is given to the deformation rate and stress developed in the material during incremental forming. The tool path for incremental forming is generated using MATLAB software. Simulations are done using Taguchi’s L9 orthogonal array method. All the simulations are done in Abaqus software. Stress developed in the material during incremental forming is determined in the simulations. The effect of each process parameter on the stress developed is investigated. Finally, Optimization of the Process parameters is done for Incremental forming process. ANOVA technique is used to find the influence of each process parameter on the stress developed in the material
The Characteristics of Everyday Life Safety Incidents among Vulnerable Groups
Authors: Park Changyeol , Park Minho
Published: October 2024

As society diversifies, everyday life safety incidents have emerged as a major social concern. Consequently, support measures for vulnerable groups who are less capable of responding to such accidents are increasingly necessary. This study is intended to diagnose the causes of everyday life safety incidents among vulnerable groups and establish preventive measures by analyzing the spatial, temporal, and variable characteristics of these accidents. The study’s findings reveal distinct spatial patterns and monthly and hourly trends in the occurrence of everyday life safety incidents, with a significant relationship between the age of the vulnerable persons and the accident type. The results of this study are expected to 1) contribute to the development of preventive measures tailored to different vulnerable groups and 2) inform regional safety policies.
A Study on the Development of a Filtration System for Drainage Discharge Capacity
Authors: Moon Jiyoung , Lee Seungwook
Published: October 2024

This study analyzes the social and economic characteristics of an area affected by chemical emission facilities and proposes policy measures to respond to social disasters such as hazardous chemical emission accidents. Even within the area affected by chemical discharge facilities, social and economic disparities existed depending on the proximity to the chemical discharge facility, child population ratio, and land value. However, the elderly population ratio decreased. It is believed that the presentation of response plans based on the study’s analysis will contribute to protecting people's health and property, which is the ultimate goal of chemical management.
Experimental Study on the Analysis of Leakage in Aged Fire Doors
Authors: Lee Yoolim , Kim Yunseong , Kim Taehyeong , Kim Hyewon , Kwon Youngjin
Published: October 2024

Aged fire doors may develop leakage cracks owing to damage from long-term use, leading to issues such as declines in the functionality of pressurization systems. This study analyzes the trends of leakage cracks in aged fire doors based on existing research and field surveys and derives the differential pressure and leakage amounts corresponding to each leakage crack via experiments conducted in a full-scale ancillary room. The results indicate that an increase in the number of leakage cracks tends to result in a decrease in the design differential pressure, which thereby prevents the fire door from performing its intended functions. Moreover, the results confirm that an increase in the number of leakage cracks also affects the leakage amounts.
Comparative Study on the Characteristics of Compartment Fire and Travelling Fire for Large-Space Fire Analysis
Authors: Kweon Ohsang
Published: October 2024

Fire models typically include standard and parametric types. These models assume that the gases produced by the fire within the compartment are fully mixed, resulting in a uniform temperature distribution. However, in real fires, significant non-uniformity is observed, and some large-compartment fires exhibit localized combustion and move across the floor of the burning room over time. This scenario is known as a “travelling fire”. In this study, the characteristics of the traditional compartment and travelling fires were compared. Combustion experiments were conducted in a medium-sized compartment with a single opening using heptane pools. Throughout these experiments, the heat-release rate and temperature changes were measured to analyze the simultaneous and delayed ignition of the flames. The experimental results showed an approximately 19% difference in the maximum heat-release rate and 50% difference in the time required to reach it. Consequently, the temperature changes within the internal compartment were also delayed and reduced.
Assessing the Need for Additional Evacuation Measures in Deep Underground Stations
Authors: Jin Dongwoo , Moon Soyun , Chae Seungun , Kim Hag Beom
Published: October 2024

Underground railroad stations face evacuation challenges owing to the rapid spread of smoke and extended escape routes during fires. Evacuation in deeply underground domestic railroad stations relies solely on stairways, with no legal standards for additional evacuation methods. In contrast, international standards such as NFPA 130 and Japan’s Fire Protection Engineering Association (JAFPE) recommend using evacuation elevators as a supplementary means of evacuation. This study analyzed smoke behavior in deep underground railroad stations through fire simulations at the Soongsil University and Guryong station. It also examined additional evacuation measures to enhance evacuation safety through evacuation simulations. The results show that during a fire, smoke spread follows the same path as the passenger evacuation routes because of the chimney effect. Even with smoke control and ventilation systems in operation, smoke follows the same evacuation routes, such as stairways or escalators. Therefore, the study concluded that evacuation elevators should be installed as an additional means to improve evacuation efficiency, and placed in smoke-protected evacuation routes. The study also found that combining evacuation stairways and elevators significantly enhances the evacuation efficiency.
Levels of Effectiveness of Water Curtain Equipment Applied When Mitigating Fire Compartment Installation of Logistics Facilities
Authors: Seo Heewon , Shon Jongwon , Kim Daehoi , Hong Sungho , Lee Sangbum , Lim Seongbin
Published: October 2024

Mock-up tests and fire simulations were performed to verify the effectiveness of water curtain equipment in mitigating fire compartment installation of logistics facilities. The radiant-heat-blocking effect of the water curtain equipment differed significantly based on the type of drencher head, and a blocking effect was observed. Additionally, the radiant temperature and heat flux were significantly reduced when the installation intervals of the drencher heads of the water curtain equipment were reduced. Therefore, improving the standards related to the water curtain equipment of logistics facilities, e.g., providing drencher head specifications, restricting the sizes of the openings, and narrowing the installation intervals of the drencher heads, is necessary to ensure the fire safety of water curtain equipment.
Pressurization System under Various Operating Conditions for Smoke Control
Authors: Kim Jungyup
Published: October 2024

The importance of smoke control systems has been emphasized for a safe evacuation and efficient firefighting activities during fire situations. To protect stairwells from smoke hazards, ‘Design Guide for Smoke Control System of Special Evacuation Stairwell and Lobby (NFPC501A)’ has been presented. In domestic area, pressurization systems utilize an air supply system consisting of fans, ducts, and dampers for supplying the outdoor air to the lobbies . For a 10-story model building, the design of the pressurization system must consider the leakage/supply flow rate, pressure loss, and fan performance. In this study, the flow field of the pressurization system under various operating conditions was analyzed using CONTAM network model.
Improvement of Safety Standards for Railway Station Platforms
Authors: Han Chungbae , Choi Youngmin , Ko Wangyoul
Published: October 2024

This study compares and analyzes the fire safety standards of both domestic and international railway station platforms by investigating the installation status of fire protection facilities in platforms with a total floor area of over 5,000 m2 in the Chungcheong region. The existing fire protection facilities require improvement in their standards by taking into account various factors, such as the location of railway stations, openness of platforms, and amount of combustible materials. The installation standards for fire protection facilities on platforms must be clearly defined and reinforced. Additionally, the installation of evacuation elevators is required for wheelchair users on underground station platforms without any open areas, as this would facilitate easy evacuation in the event of a fire.
Assessment of Overflow Risk in Agricultural Reservoir Based on Water Balance Theory
Authors: Shim Kyuhyun , Heo Jun , Jin Youngkyu
Published: October 2024

The unexpected climate changes are causing rainfalls to exceed the design frequency, which complicates the management and operation of agricultural reservoirs and increases the risk of overflow. According to the “Planning and Design Standards for Agricultural Prediction Infrastructure Maintenance Project (Fill Dam Section),” agricultural reservoirs were originally designed without flood control functions, with the standard being to directly discharge incoming flood. Based on this foundation, this study assesses the overflow risk of agricultural reservoirs using the concepts of inflow and outflow theories as well as storage capacity. The balance when inflow and outflow are at their maximum was analyzed for prioritized areas, focusing on the flood management area (the area between the full water level and crest elevation) relative to the basin area, to examine the feasibility of balance through flood routing. The proposed method is easily accessible to facility managers, enabling them to assess the risk of reservoirs for efficient management and operation during floods.
Effect of Vehicle Load on the Fatigue Cracks of the Center-stay for a Steel Girder Deck in a Suspension Bridge
Authors: Kim Dae-Hwan , Park Chanhyun , Ha Min-Gyun , Ahn Jin-Hee
Published: October 2024

Steel deck systems are widely used in cable-stayed and suspension bridges because of their various advantages. However, the direct effect of vehicle loads often leads to fatigue cracks in steel decks, particularly at the intersections of the longitudinal and transverse ribs, which have been the focus of most studies. In the target bridge of this study, unlike the location where fatigue cracking generally occurs, cracks were detected in the vertical stiffener inside the stiffening girder just below the center-stay and that adjacent to the center-stay. A precise analysis was performed to determine the cause of fatigue cracking, and the analysis model was verified by comparing it with the results of an existing load test. This study examined the effects of heavy vehicle loads by adjusting the vehicle weight and changing the position of the vehicle. This study confirms that as the vehicle load increases, fatigue cracing may occur in the internal vertical stiffener of the center-stay stiffening girder, leading to subseuent cracs in the external center-stay.
Stability Assessment of Weirs Reinforced with Sheet Piles
Authors: Kim Jihoon , Kim Mintae
Published: October 2024

Extreme weather events induced by climate change are increasing across the world. In particular, floods resulting from unpredictable heavy rains cause significant damage to property and human life. In Korea, river and underwater structure management is performed continuously in accordance with strict regulations. However, to prepare for unprecedented downpours, the structures of river reservoirs must be reinforced and their stability must be evaluated. This study focuses on the stability evaluation of piping, which represents the main cause of weir collapse. To this end, sheet piles are applied to weirs to evaluate the effects of changes in their length and location on their seepage discharge, seepage velocity, and maximum hydraulic gradient. Additionally, piping stability evaluation of weirs is conducted using sheet piles by evaluating the critical velocity. The results derived in this study are expected to be highly beneficial for reinforcing weirs currently in operation as well as for the design, construction, and operation of future underwater structures.