bluuebunny/crossref_metadata_2025 huggingface dataset:
Airway Management of the Right Anterior Segmentectomy through Uniportal Video-Assisted Thoracoscopic Surgery (VATS) after Left Pneumonectomy by An Adapted Double-lumen Endobronchial Tube (DLT): A Case Report
Authors: Gu Yang , Duan Ruowang , Song Jiong , Lv Xin
Published: January 2019

Background: Lung resection after previous contralateral pneumonectomy is rare. We present a case of right anterior segmentectomy despite previous left pneumonectomy, demanding special airway management strategy.
Case presentation: A 48-year-old woman was going to have the right anterior segmentectomy through uniportal video-assisted thoracoscopy (VATS) who had left pneumonectomy two years ago. A 32-French left-sided double-lumen endobronchial tube (DLT) was chosen and adapted. The DLT was intubated into the bronchus intermedius. And the upper lobe can be isolated from the ventilation in the middle and lower lobes when the bronchial cuff’s inflated. The perioperative period was uneventful and the pathological diagnosis was adenocarcinoma.
Conclusion: Lung cancer radical resection was discouraged after previous contralateral pneumonectomy partly due to the challenging ventilation and isolation. With this new DLT adapting and intubation technique showed in this case, the challenging ventilation and isolation that deter the promotion of the operation could be solved.
Intraoperative Management of Brain-dead Organ Donors by Anesthesiologists during an Organ Procurement Procedure: Results from a French survey
Authors: Champigneulle Benoit , Neuschwander Arthur , Bronchard Régis , Favé Gersende , Josserand Julien , Lebas Benjamin , Bastien Olivier , Pirracchio Romain
Published: January 2019

Background: There is no specific guidelines concerning intraoperative management of brain-dead donors (BDD) during organ procurement (OP). This study aimed at describing usual anesthetic practices for BDD during an OP procedure and to assess the knowledge and self-confidence of French anesthesiologists with this practice.
Methods: An electronic, national and anonymous survey with closed-questions about anesthetic management of BDD was distributed to French anesthesiologists via the mailing list of the French Society of Anesthesiology and Intensive Care. The questionnaire included questions concerning monitoring, intraoperative resuscitation, anesthetic drugs use and confidence of the respondents.
Results: 458 responses were analyzed. Respondents were mainly attending physicians with more than 10 years of professional experience, equally distributed between university and non-university centers. Seventy-eight percent of them declared knowledge about guidelines regarding ICU management of BDD. Advanced hemodynamic monitoring and endocrine substitution were poorly considered by respondents (31% and 35% of respondents, respectively). 98% of the respondents used crystalloids for fluid resuscitation. During the procedure, use of neuromuscular blockers, opioids and sedative agents were considered by respectively 84%, 61% and 27% of the respondents. A very high level of agreement (10 [8-10], on a ten-points Likert-style scale) was reported concerning the expected impact of intraoperative anesthetic management on the primary function of grafts.
Conclusions: Declared anesthetic practice appeared in accordance with guidelines concerning ICU management of organ donors. Further studies are needed to evaluate the specific impact of intraoperative management during this procedure and thus the need for specific anesthetic guidelines.
A cerebral Arteriovenous Malformation mistakenly diagnosed as Dry Eye and Glaucoma: a case report
Authors: Shen Shuhao , Liu Xiaoyong , Chen Jian , Yang Chengyou , Shi Changzheng , Zhou Qing
Published: January 2019

Background: To report a case of a cerebral Arteriovenous Malformation(AVM) with eye symptoms firstly and review the characteristic of this case and the main confusing point for diagnosis of such case.
Case presentation: A 58-year-old women presented to the ophthalmology clinic with 1 and an half year of right eye redness, Ocular hypertension and recurrent headache. One and a half year ago she was diagnosed as right eye dry eye and glaucoma and had received treatment according to diagnosis, however all the treatment did not lead to any improvement of redness and headache. On physical examination, it revealed dry eye and severe corkscrew hyperemia with dilated vessels in the right eye. After we consider that the symptom may be related to intracranial abnormal vessels, Computed tomography angiography and venography (CTA+CTV) were performed and the results showed an arteriovenous malformation (AVM) of right parietal-occipital area in the brain. The AVM was definitely located by the further examination of Digital subtraction angiography (DSA). After the AVM endovascular embolism treatment, the conjunctival congestion of the right eye was significantly relieved and the intraocular pressure was decreased to normal.
Conclusion: In clinical practice, when found corkscrew hyperemia accompanied by neurological symptoms, it might be considered as a result from cerebral vessels diseases, so in this case ophthalmologists diagnosis should combine disease history and imaging examination.
Key word: cAVM, DSA, hyperemia, glaucoma
Risk Factors for and Management of Anterior Chamber Intravitreal Dexamethasone Implant Migration
Authors: Röck Daniel , Bartz-Schmidt Karl Ulrich , Röck Tobias
Published: January 2019

Background: This study aimed to investigate the incidence of and risk factors for the anterior chamber migration of an intravitreal dexamethasone implant (Ozurdex®).
Methods: A retrospective review of 640 consecutive intravitreal dexamethasone implant injections was conducted from February 2011 through February 2018 at the University Eye Hospital in Tübingen, Germany. Those patients who experienced anterior chamber dexamethasone implant migrations were identified, as well as the reasons for the anterior chamber migration. The surgical histories were obtained and comprehensive ophthalmic examinations were conducted for all of the eyes. Cross-tabulations, chi-squared tests, and Fisher's exact tests were used to assess the influences of different factors on the anterior chamber implant migrations.
Results: Overall, 4 eyes of four patients (0.63%) showed anterior chamber implant migrations. All four of the eyes were pseudophakic, and they had undergone prior vitrectomies. Three eyes had sclerally-fixated intraocular lenses, and one eye had a posterior chamber intraocular lens in the capsular bag, with a capsular tension ring due to partial zonular dehiscence. When comparing the vitrectomized eyes with reduced zonular/capsular bag complex integrity to the vitrectomized pseudophakic eyes with intact zonular/capsular bags, the former were significantly associated with an increased risk of anterior chamber implant migration (P = 0.008). The vitrectomized pseudophakic eyes, in contrast to the nonvitrectomized pseudophakic eyes, were significantly associated with an increased risk of anterior chamber implant migration (P = 0.009).
Conclusions: The anterior chamber migration of an intravitreal dexamethasone implant is a serious complication. To minimize the risk of permanent corneal edema, immediate removal of the implant is important. Those patients with insufficient zonular support, defects, or missing posterior capsular membranes and vitrectomy histories present a high risk of anterior chamber dexamethasone implant migration.
Delayed-Onset Interface Fluid Syndrome After LASIK Following Phacotrabeculectomy
Authors: Kim Chung Young , Jung Young Ho , Lee Eun Ji , Hyon Joon Young , Park Kyu Hyung , Kim Tae Woo
Published: January 2019

Background: Interface fluid syndrome (IFS) is an unusual complication after laser-assisted in-situ keratomileusis (LASIK). We report the first case of IFS after uncomplicated phacotrabeculectomy in a patient who had undergone LASIK 10 years previously. This case emphasizes the importance of intraocular pressure (IOP) interpretation in eyes that have undergone LASIK.
Case presentation: A 30-year-old woman with a history of LASIK surgery presented to glaucoma clinic due to uncontrolled IOP despite of maximally tolerable medical treatment. After receiving phacotrabeculectomy, IOP decreased to 3mmHg on the first postoperative day, but again increased up to 21mmHg and a diffuse corneal edema with cloudy flap interface was demonstrated by slit-lamp microscopy. Corneal edema was sustained even after the IOP was lowered to 14 mmHg. Spectral-domain optical coherence tomography scanning of the cornea revealed a diffuse, thin fluid pocket in the corneal interface. After laser lysis of the scleral flap sutures, IOP was further decreased to 9mmHg and interface fluid was resolved.
Conclusion: IFS should be considered as a possible cause of postoperative corneal edema despite of low IOP in the eyes that underwent LASIK surgery. Additional IOP lowering may be helpful for resolving the corneal edema.
Key Words : Interface fluid syndrome, LASIK, Glaucoma, Phacotrabeculectomy.
Intra-operative red blood cell transfusion and mortality after cardiac surgery
Authors: Vlot Eline A , Verwijmeren Lisa , de Garde Ewoudt M.W. Van , Kloppenburg Geoffrey T.L. , Dongen Eric P.A. Van , Noordzij Peter G.
Published: January 2019

Background
Anemia in cardiac surgery patients has been associated with poor outcomes. Transfusion of red blood cells during surgery is common practice for perioperative anemia, but may come with risks. Little is known about the association between intra-operative transfusion and mortality in patients undergoing cardiac surgery.
Methods
Single centre historical cohort study in 2933 adult patients undergoing coronary surgery with or without aortic valve replacement from June 2011 until September 2014. To estimate the odds ratio for mortality in patients receiving intra-operative transfusion, a propensity score based logistic regression analysis was performed.
Results
Intra-operative transfusion was associated with a more than three-fold increased risk of 30-day mortality. Patients in the highest quartile of probability of transfusion were older (age 75 vs 66; P<0.001), had a higher EuroSCORE (6 vs 3; P<0.001), had lower preoperative hemoglobin levels (7.6 vs 8.9 mmol/l; P<0.001), had combined surgery more often (CABG + AVR in 33.4 % of cases vs 6.6 % (P<0.001) and a longer duration of surgery (224 vs 188 minutes; P<0.001). The association between intra-operative transfusion and mortality persisted after adjustment for these risk factors (adjusted OR 2.6; P=0.007).
Conclusions
Intra-operative transfusion of red blood cells was found to be associated with increased mortality in adults undergoing coronary surgery. Preoperative patient optimization may improve perioperative outcomes by reducing the likelihood of requiring transfusion and thus its associated risk.
Educational Intervention for Effective Postoperative Pain Management in Low Resource Settings: Evidence from Ethiopia
Authors: Eshete Million Tesfaye , Baeumler Petra I. , Tesfaye Markos , Ayele Yemane , Haileamlak Abraham , Michael Girma G , Irnich Dominik , Siebeck Matthias
Published: January 2019

Background
The annual number of surgical operations performed is increasing throughout the world. With this rise in the number of surgeries performed, so too, the challenge of effectively managing postoperative pain. Healthcare professionals and patients in education might help in controlling postoperative pain effectively. However, data from low-income countries investigating the impact of educational intervention on postoperative pain are very scanty, and reports from the developed settings are inconclusive. The study has investigated the impact of preoperative patient education and health care professionals education on improving the quality of postoperative pain management; in patients scheduled for major elective orthopedic, gynecologic and general surgery; as measured by patient-reported outcomes.
Methods
This was a quasi-experimental, non-equivalent control group design with before and after measures. We have recruited 700 consecutive patients; who are eighteen years or more, scheduled for general, orthopedic and gynecologic surgery. Outcome measures were patient-reported outcomes (postoperative pain intensity, pain interference, and perception of care) and adequacy of pain management used.
Results
Generally, no significant difference was observed in most outcome measures except for the worst level of pain, least level of pain, patient participation in decision making and feeling of drowsiness between the treatment and control group.
Conclusion
Results of this study contained very important information in understanding the effectiveness of educational interventions in the postoperative setting. The treatment was successful in increasing patients participation in decision making, as anticipated. However, its impact on decreasing pain intensity was only noted at the last measurement point after surgery.
The role of water distribution networks in water supply
Authors: Nyende-Byakika Stephen
Published: January 2019

In water supply management it is commonly thought that consumer satisfaction depends mostly on the amount of water discharged to a network. Because of this, complaints about inadequate supply are usually blamed on insufficient production. However, a recent study by the author indicated that the water distribution and supply network is equally important. A water network modelled in EPANET2 hydraulic solver was subjected to various conditions and constraints, and its responses analyzed. For water to be supplied efficiently, and in addition to augmenting production, greater emphasis must be put on the distribution system. This must be designed and optimized appropriately, to deliver water at the required pressure and discharge. In particular, higher pressures can be obtained when larger diameter pipes are used because friction losses are reduced, thereby reducing pumping costs. One way to improve pressure is by limiting demand.
Wavelet and statistical analyses of river water quality parameters: a case study in the Lower Minnesota River
Authors: Gao Ang , Wu Shiqiang , Zhu Senlin , Xu Zhun
Published: January 2019

Statistical and wavelet analyses are useful tools for analyzing river water quality parameters. In this study, they were employed to study parameters including biochemical oxygen demand (BOD), dissolved oxygen (DO), nitrate (NO3), ammonium (NH4), phosphate (PO4), total phosphorus (TP), total Kjeldahl nitrogen (TKN), chlorophyll a (CHLA), total suspended solids (TSS) and water temperature (TEMP) monitored at five hydrologic stations on the Lower Minnesota River, USA. Strong positive correlations were observed between CHLA-BOD, TP-TKN, TP-TSS and TKN-TSS, with strong negative correlation between DO-TEMP. Daubechies wavelet at level 5 has been calculated for some key water quality parameters as it gives the finer scale approximation and decomposition of each water parameter. The results show that TEMP and DO have relative quasi-periodicity of about one year, while the quasi-periodicity of NH4 and PO4 are weaker than for TEMP and DO. Correlations between some parameters based on wavelet decomposition results are consistent. The fluctuation range characteristics of some parameters were also analyzed through wavelet decomposition.
Contamination of groundwater sources in emerging African towns: the case of Babati town, Tanzania
Authors: Pantaleo P. A. , Komakech H. C. , Mtei K. M. , Njau K. N.
Published: January 2019

Assessment of groundwater contamination potential was carried out in Babati, Manyara, Tanzania. Diazotization, cadmium reduction, ascorbic acid, ion selective electrode and membrane filtration analytical methods were used, respectively, for nitrite, nitrate, phosphate, fluoride and microbial investigations. Fecal coliforms (FC) and high NO3 concentrations were present in wells less than 30 m deep. The maximum FC level was 280 CFU/100 ml, and the nitrate (NO3) ranged from 1.1 to 357.7 mg-NO3/l. In boreholes, nitrate concentrations ranged from 2.3 to 32.6 mg-NO3/l, below both national and WHO standards, and were all free of fecal coliform. Other parameters were all within recommended limits for all wells tested. Evaluation of the potential contamination pathways revealed that the shallow well depths ranged from 1.2 to 26.67 m – median 9 m (N = 366): 70% were unlined and 19% were uncovered. About 74% of the wells were within 30 m of sanitation facilities, of which 60% were traditional pit latrines. The findings revealed that most shallow wells (64%) are polluted and could cause health problems for users. Therefore, it is prudent that the community avoids relying on shallow wells. Boiling of domestic water before use is highly recommended.
Revisitando os determinantes da distribuição de dividendos: uma análise em empresas brasileiras
Authors: Leite Maurício , Bogoni Nadia Mar , Hein Nelson
Published: January 2019

Banco de dados brutos de pesquisa.
Systems Biology: A Powerful Tool for Drug Development
Authors: Rai Sneha , Raj Utkarsh , Varadwaj Pritish Kumar
Published: January 2019

The conventional way of characterizing a disease consists of correlating clinical symptoms
with pathological findings. Although this approach for many years has assisted clinicians in establishing
syndromic patterns for pathophenotypes, it has major limitations as it does not consider preclinical
disease states and is unable to individualize medicine. Moreover, the complexity of disease biology is
the major challenge in the development of effective and safe medicines. Therefore, the process of drug
development must consider biological responses in both pathological and physiological conditions.
Consequently, a quantitative and holistic systems biology approach could aid in understanding complex
biological systems by providing an exceptional platform to integrate diverse data types with molecular
as well as pathway information, leading to development of predictive models for complex diseases.
Furthermore, an increase in knowledgebase of proteins, genes, metabolites from high-throughput experimental
data accelerates hypothesis generation and testing in disease models. The systems biology
approach also assists in predicting drug effects, repurposing of existing drugs, identifying new targets,
facilitating development of personalized medicine and improving decision making and success rate of
new drugs in clinical trials.
The Impact of Pediatric Epilepsy on Children and Families: A Multicenter Cross-Sectional Study
Authors: Subki Ahmed Hussein , Mukhtar Abdel Moniem , Al-Harbi Rakan Salah , Alotaibi Abdulaziz Khaled , Mosaad Faisal Ghazi , Alsallum Mohammed Saad , Jan Mohammed M.S.
Published: January 2019

Background and Objectives:

Epilepsy is considered one of the most prevalent causes of morbidity in children. The aim of this study is to determine how epilepsy impacts the lives of children with epilepsy and their families.

Methods:

A translated version of the “Impact of Pediatric Epilepsy Scale” (IPES) questionnaire was completed by the 80 mothers of children with epilepsy, recruited at three hospitals in Jeddah, Saudi Arabia This is a validated self-administered questionnaire used to assess the impact of epilepsy on the lives of the child and family, as well as the quality of life (QoL) of the child.

Results:

The mean age of children epilepsy was 6.32 years (SD = 3.22). The mean IPES score was 6.28 (SD = 8.42) and the mean child’s QoL was 2.85 (SD= 0.83). 87.5% of the mothers rated their child’s QoL as low. IPES score was significantly associated with cause of seizure (β=0.259; 95%-CI= 0.263 - 10.334; p = 0.039). Child’s QoL was significantly associated with frequency of seizure (β=0.251; 95%-CI= 0.016 - 0.568; p= 0.039) and child’s nationality (β=-0.270; 95%-CI -0.252, -0.013; p= 0.031).

Conclusions:

Pediatric epilepsy may have a greater impact on the lives of the child and the family when it is not comorbid with cerebral palsy. Quality of life tends to be lower for non-Saudi children, and children with more frequent seizures. Therefore, these groups may need more support in managing the impact that epilepsy has on their daily functioning and quality of life.
Biosimilars in Rheumatic Diseases: Regulatory Guidelines, Efficacy and Safety Implications in Saudi Arabia
Authors: Halabi Hussein , Al Zahrani Zeyad , Al Swailem Ramiz , Husain Waleed , Al Rayes Hanan , Al Osaimi Hanan , El Dershaby Yasser , Ahmed Haytham Mohamed , Mounir Mohamed , Omair Mohammed A.
Published: January 2019

Background:

Treatment with biologic drugs has enabled many patients with inflammatory rheumatic disease to achieve disease control. In some areas of the world, limited access to biologic therapies has created a demand for lower cost options such as biosimilars, which are highly similar, but not identical to originator biologics. The safe use of biosimilars requires a scientifically rigorous review process for their approval, and guidelines that aid rheumatologists in their use.

Discussion:

In Saudi Arabia, there are no national or regional guidelines to assist rheumatologists in the proper use of biosimilars in clinical practice, and this may potentially affect the quality of patient care. In this review, we discuss the importance of developing a guidance and the need for healthcare professionals and patients to receive education about biosimilars. We discuss the unique requirements for biosimilar approval, and the differences between biosimilars, originator biologics, and generics. We review important considerations related to biosimilar use, such as switching from originator biologics to biosimilars, switching between different biosimilars, interchangeability, automatic substitution, naming, and pharmacovigilance. We also provide recommendations based on the authors’ expert opinions as rheumatologists to help ensure the appropriate use of biosimilars in Saudi Arabia.

Conclusion:

The approval and use of biosimilars must be supported by scientifically sound evidence. Guidelines for the use of biosimilars are needed in Saudi Arabia to aid rheumatologists in making clinical decisions. Additionally, educational resources should be provided to healthcare professionals and patients.
Polytechnic to Business Project (P2B) a Case of Innovation and Knowledge Transference
Authors: Paiva Teresa
Published: January 2019

Background:

The theoretical background of this article is on the model
developed of knowledge transfer between universities and the industry in order to
access the best practices and adapt to the study case in question regarding the
model of promoting and manage innovation within the universities that best
contribute with solution and projects to the business field.

Objective:

The development of a knowledge transfer model is the main goal of this
article, supported in the best practices known and, also, to reflect in the main
measurement definitions to evaluate the High Education Institution performance in
this area.

Methods:

The method for this article development is the case study method because
it allows the fully understanding of the dynamics present within a single setting, and
the subject examined to comprehend what is being done and what the dynamics
mean. The case study does not have a data collection method, as it is a research that
may rely on multiple sources of evidence and data which should be converged.

Results:

Since it’s a case study this article present a fully description of the model
proposed and implemented for the knowledge transfer process of the institution.

Conclusion:

Still in a discussion phase, this article presents as conclusions some
questions and difficulties that could be pointed out, as well as some good
perspectives of performed activity developed.
Dental Educators’ Perceptions of Educational Learning Domains
Authors: Hoskin Eileen R. , Johnsen David C. , Saksena Yun , Horvath Zsuzsa , de Peralta Tracy , Fleisher Neal , Marshall Teresa A. , Leone Cataldo
Published: January 2019

The aim of this study was to seek the views of a national sample of dental educators regarding the importance of learning domains in dental education, their defined outcomes of those domains, and their perceived effectiveness of their schools in guiding learning in those domains. The study defined the educational domains important for training future dentists as knowledge, technical skills, critical thinking, ethics, social responsibility, and interprofessional education/practice (IPE/IPP). A survey of members of the American Dental Education Association (ADEA) Special Interest Group on the Scholarship of Teaching and Learning was conducted in 2017. In addition to reporting their demographics, participants were asked to rate and rank the importance of each learning domain as well as answer open‐ended questions. Of the 89 respondents (response rate 12.5%), 31% were course directors, and 48% had been dental faculty members for more than ten years. Knowledge was ranked as the most important domain, followed by critical thinking, technical skills, clinical decision making, ethics, problem‐solving, social responsibility, and finally IPE/IPP. When rating the absolute importance of these domains in the training of dental students, the respondents gave all but IPE/IPP and social responsibility the highest rating. Knowledge and technical skills were rated highest for respondents’ confidence in defining student outcomes with similar high ratings for their confidence in guiding this learning. There was little consensus concerning a definition of critical thinking, and a third of the respondents were uncertain of specific learning outcomes for it. Participants expressed even less confidence in defining outcomes for ethics, IPE/IPP, and social responsibility. This baseline information will be used for a future in‐depth study to aid in the development of strategies for articulating outcomes, guiding learning, and assessing performance in U.S. dental schools.
As formas alternativas de solução de conflitos no código de processo civil: o processo pensado sob o prisma democrático
Authors: Rodrigues Alexsandra Gato , Lyra José Francisco Dias da Costa
Published: January 2019

No decorrer da história da humanidade os conflitos humanos foram submetidos a diferentes formas de tratamento e solução. Almeja-se um processo civil associado a um Judiciário difundido, que identifique as diferenças através de um poder compartilhado por todos os sujeitos que atuam no processo em um dimensionamento espaço-temporal compatível às exigências constitucionais. A mediação ganha ênfase no âmbito do Poder Judiciário brasileiro através de políticas públicas voltadas ao incentivo do uso dos métodos autocompositivos no tratamento e controle dos conflitos interpessoais e do demandismo exagerado. Com o advento do Código de Processo Civil de 2015 o direito brasileiro consolidou a adoção, o estímulo e a aplicabilidade dos métodos alternativos de solução de conflitos no âmbito do Poder Judiciário.Neste contesto indaga-se as formas alternativas de solução de conflitos no código de processo civil surgem como uma nova alternativa processual pensado sob o prisma democrático? Para enfrentar este questionamento, utilizar-se-á como teoria de base o método dedutivo, com a técnica de pesquisa bibliográfica. Assim, propõe-se o Código de Processo Civil através das formas autocompositivas, em uma espécie de conclamação para que o Poder Judiciário supere as relações de subordinação para as relações de cooperação, busque uma Justiça que estimule mais a cultura das soluções consensuais de conflitos
Da redistribuição de renda ao reconhecimento identitário: o contexto das mulheres camponesas a partir da Constituição Federal de 1988
Authors: Schnorrenberger Neusa , Angelin Rosângela
Published: January 2019

Utilizando o método de procedimento analítico-histórico e a abordagem dedutiva, o presente texto, por meio de um estudo bibliográfico, histórico, doutrinário e de legislações e normas constitucionais, pretende analisar quais avanços as mulheres camponesas obtiveram com a Constituição Federal de 1988, em especial no que se refere ao reconhecimento identitário e a distribuição de renda. Com base nas ponderações levantadas, a presente pesquisa, em um primeiro momento, verifica a desigualdade e diferença, enquanto fatores das identidades femininas. Posteriormente, averígua-se a constituição das identidades das mulheres camponesas, a partir de movimentos do campo. Por fim, abordam-se questões de redistribuição e reconhecimento identitários das camponesas frente à Constituição de 1988. Com base nas análises desenvolvidas a partir das teorias da redistribuição econômica e do reconhecimento identitário, observa-se a importância dos movimentos de mulheres camponesas para resignificar o papel identitário dessas mulheres, bem como para lograr redistribuição de renda, ambos aspectos positivados constitucionalmente.
Incorporating Information From Electronic and Social Media Into Psychiatric and Psychotherapeutic Patient Care: Survey Among Clinicians (Preprint)
Authors: Hobbs Katherine W , Monette Patrick J , Owoyemi Praise , Beard Courtney , Rauch Scott L , Ressler Kerry J , Vahia Ipsit V
Published: January 2019

BACKGROUND

Obtaining collateral information from a patient is an essential component of providing effective psychiatric and psychotherapeutic care. Research indicates that patients’ social and electronic media contains information relevant to their psychotherapy and clinical care. However, it remains unclear to what degree this content is being actively utilized by clinicians as a part of diagnosis or therapy. Moreover, clinicians’ attitudes around this practice have not been well characterized.

OBJECTIVE

This survey aimed to establish the current attitudes and behaviors of outpatient clinicians regarding the incorporation of patients’ social and electronic media into psychotherapy.

METHODS

A Web-based survey was sent to outpatient psychotherapists associated with McLean Hospital in Belmont, Massachusetts. The survey asked clinicians to indicate to what extent and with which patients they reviewed patients’ social and electronic media content as part of their clinical practice, as well as their reasons for or against doing so.

RESULTS

Of the total 115 respondents, 71 (61.7%) indicated that they had viewed at least one patient’s social or electronic media as part of psychotherapy, and 65 of those 71 (92%) endorsed being able to provide more effective treatment as a result of this information. The use of either short message service text messages or email was significantly greater than the use of other electronic media platforms (χ21=24.1, n=115, P<.001). Moreover, the analysis of survey responses found patterns of use associated with clinicians’ years of experience and patient demographics, including age and primary diagnosis.

CONCLUSIONS

The incorporation of patients’ social and electronic media into therapy is currently common practice among clinicians at a large psychiatric teaching hospital. The results of this survey have informed further questions about whether reviewing patient’s media impacts the quality and efficacy of clinical care.
Applicability of the User Engagement Scale to Mobile Health: A Survey-Based Quantitative Study (Preprint)
Authors: Holdener Marianne , Gut Alain , Angerer Alfred
Published: January 2019

BACKGROUND

There has recently been exponential growth in the development and use of health apps on mobile phones. As with most mobile apps, however, the majority of users abandon them quickly and after minimal use. One of the most critical factors for the success of a health app is how to support users’ commitment to their health. Despite increased interest from researchers in mobile health, few studies have examined the measurement of user engagement with health apps.

OBJECTIVE

User engagement is a multidimensional, complex phenomenon. The aim of this study was to understand the concept of user engagement and, in particular, to demonstrate the applicability of a user engagement scale (UES) to mobile health apps.

METHODS

To determine the measurability of user engagement in a mobile health context, a UES was employed, which is a psychometric tool to measure user engagement with a digital system. This was adapted to Ada, developed by Ada Health, an artificial intelligence–powered personalized health guide that helps people understand their health. A principal component analysis (PCA) with varimax rotation was conducted on 30 items. In addition, sum scores as means of each subscale were calculated.

RESULTS

Survey data from 73 Ada users were analyzed. PCA was determined to be suitable, as verified by the sampling adequacy of Kaiser-Meyer-Olkin=0.858, a significant Bartlett test of sphericity (χ2300=1127.1; P<.001), and communalities mostly within the 0.7 range. Although 5 items had to be removed because of low factor loadings, the results of the remaining 25 items revealed 4 attributes: perceived usability, aesthetic appeal, reward, and focused attention. Ada users showed the highest engagement level with perceived usability, with a value of 294, followed by aesthetic appeal, reward, and focused attention.

CONCLUSIONS

Although the UES was deployed in German and adapted to another digital domain, PCA yielded consistent subscales and a 4-factor structure. This indicates that user engagement with health apps can be assessed with the German version of the UES. These results can benefit related mobile health app engagement research and may be of importance to marketers and app developers.
Understanding Long-Term Trajectories in Web-Based Happiness Interventions: Secondary Analysis From Two Web-Based Randomized Trials (Preprint)
Authors: Sanders Christopher A , Schueller Stephen M , Parks Acacia C , Howell Ryan T
Published: January 2019

BACKGROUND

A critical issue in understanding the benefits of Web-based interventions is the lack of information on the sustainability of those benefits. Sustainability in studies is often determined using group-level analyses that might obscure our understanding of who actually sustains change. Person-centric methods might provide a deeper knowledge of whether benefits are sustained and who tends to sustain those benefits.

OBJECTIVE

The aim of this study was to conduct a person-centric analysis of longitudinal outcomes, examining well-being in participants over the first 3 months following a Web-based happiness intervention. We predicted we would find distinct trajectories in people’s pattern of response over time. We also sought to identify what aspects of the intervention and the individual predicted an individual’s well-being trajectory.

METHODS

Data were gathered from 2 large studies of Web-based happiness interventions: one in which participants were randomly assigned to 1 of 14 possible 1-week activities (N=912) and another wherein participants were randomly assigned to complete 0, 2, 4, or 6 weeks of activities (N=1318). We performed a variation of K-means cluster analysis on trajectories of life satisfaction (LS) and affect balance (AB). After clusters were identified, we used exploratory analyses of variance and logistic regression models to analyze groups and compare predictors of group membership.

RESULTS

Cluster analysis produced similar cluster solutions for each sample. In both cases, participant trajectories in LS and AB fell into 1 of 4 distinct groups. These groups were as follows: those with high and static levels of happiness (n=118, or 42.8%, in Sample 1; n=306, or 52.8%, in Sample 2), those who experienced a lasting improvement (n=74, or 26.8% in Sample 1; n=104, or 18.0%, in Sample 2), those who experienced a temporary improvement but returned to baseline (n=37, or 13.4%, in Sample 1; n=82, or 14.2%, in Sample 2), and those with other trajectories (n=47, or 17.0%, in Sample 1; n=87, or 15.0% in Sample 2). The prevalence of depression symptoms predicted membership in 1 of the latter 3 groups. Higher usage and greater adherence predicted sustained rather than temporary benefits.

CONCLUSIONS

We revealed a few common patterns of change among those completing Web-based happiness interventions. A noteworthy finding was that many individuals began quite happy and maintained those levels. We failed to identify evidence that the benefit of any particular activity or group of activities was more sustainable than any others. We did find, however, that the distressed portion of participants was more likely to achieve a lasting benefit if they continued to practice, and adhere to, their assigned Web-based happiness intervention.
Minimum Information About a Google Trends Experiment (MIAGE) (Preprint)
Authors: Bragazzi Nicola Luigi
Published: January 2019

UNSTRUCTURED

In the era of the evidence-based medicine, ensuring standardization and reproducibility is crucial. The “minimum information” standard is a new conceptual framework that comprises a set of checklists, protocols and/or guidelines for performing experiments and reporting the resultant, generated data (experimental data) along with essential information about the experiments themselves (metadata or contextual data).
Google Trend (GT) is a new, freely available, web-based tracking system that enables a visualization of hit-search volumes throughout the years, from 2004 on. GT proved particularly successful especially for infectious diseases epidemics. Its enormous potentiality and applications have been exploited in many other fields of medicine, however most research conducted with GT is poorly reproducible.
Minimum Information About a Google Trends Experiment (MIAGE) is a 23-item checklist that can facilitate and accelerate research in the field of digital health. MIAGE can enable the scientific community to produce more open, transparent, reliable investigations, whose data (both experimental and contextual) can be easily shared and reused for the sake of progress.
Indeks Pengarang Buletin Psikologi
Authors: Pengarang Indeks
Published: January 2019

Indeks Pengarang Buletin Psikologi
THE ACTIVE FRACTION FROM Nigella sativa AND ITS ACTIVITY AGAINST T47D CELL LINE
Authors: Ekowati Heny , Prasasti Eka , Rastuti Undri
Published: January 2019

Breast cancer is one of the main causes of death in women. Cancer treatment with surgery, chemotherapy, and radiology often cause undesirable side effects. Therefore, alternative cancer treatment by using plants as traditional medicine was expected to reduce side effects. Nigella sativa is one of the plants used as anticancer empirically. This study conducted to examine the cytotoxic activity of Nigella sativa seeds and identify its components on T47D breast cancer cells. Petroleum ether, chloroform, ethyl acetate, and ethanol were used to extract N. sativa seeds. The extracts were tested their cytotoxic activity on T47D cell line using MTT method. The active compound was separated using column chromatography. Cytotoxic test on T47D cell line was perform for extracts of each separation stage. Data were analyzed by probit analysis to obtain IC50 values. Components identification was performed using GC-MS analysis. The results showed that chloroform extract has cytotoxic activity better than other extracts with IC50 of 124.206 µg/mL. The third fraction has cytotoxic activity better than other fractions with IC50 of 68.568 µg/mL. The GC-MS analysis showed that in the third fraction of the chloroform extract contain linoleat acid, the major compound and tryptamine.
SYNTHESIS OF TERPINEOL FROM α-PINENE CATALYZED BY TCA/Y-ZEOLITE
Authors: Wijayati Nanik , Pranowo Harno Dwi , Jumina Jumina , Triyono Triyono
Published: January 2019

The hydration of a-pinene has been studied in the presence of TCA/Y-Zeolite catalyse. The catalyst was prepared by impregnating trichloroacetic acid (TCA) on support of Y-Zeolite. The TCA/Y-Zeolite catalyst converted a-pinene into hydrocarbons, while the TCA/Y-Zeolite catalyst was active and selective for producing alcohols, with a conversion of 66% and showed 55% selectivity for α-terpineol at 10 min. The reaction taken place in a solid-liquid mode and most of the α-terpineol is extracted out by the organic phase during the course of the reaction. TCA/Y-Zeolite was found as good catalyst for hydration of α-pinene to produce α-terpineol.
HYDROLYSIS OF CARBOHYDRATES IN CASSAVA PULP AND TAPIOCA FLOUR UNDER MICROWAVE IRRADIATION
Authors: Hermiati Euis , Azuma Jun-ichi , Mangunwidjaja Djumali , Sunarti Titi C. , Suparno Ono , Prasetya Bambang
Published: January 2019

Cassava pulp and tapioca flour are potential sources of glucose. In this work, validity of microwave irradiation for hydrolysis of carbohydrates, especially starch, present in cassava pulp and tapioca flour was estimated as a non-enzymatic saccharification technique. Suspension of cassava pulp or tapioca flour in distilled water (1g/20 mL) was subjected to microwave irradiation at temperatures of 140-240 °C with pre-heating time of 4 min and heating time of 5 min. Solubilization rate of cassava pulp increased with increasing temperature of microwave heating treatment and reached maximum (92.54%) at 220 °C, while that of tapioca flour reached almost 100% at 140 °C. Production of malto-oligomers from starch in cassava pulp and tapioca flour was clearly observed at 220 °C. The highest glucose yields from cassava pulp and tapioca flour in this experiment were 28.59 and 58.76% dry matter, respectively. Variation of pre-heating time at 230 °C did not give significant effects on glucose yield from cassava pulp. However, glucose yield from tapioca flour decreased due to increase of pre-heating time. Microwave irradiation is a promising method of hydrolysis for cassava pulp and tapioca flour due to the fast process.
FABRICATION AND CHARACTERIZATION OF CARBON COMPOSITE FROM COCONUT SHELL CARBON
Authors: Rampe Meytij Jeanne , Setiaji Bambang , Trisunaryanti Wega , Triyono Triyono
Published: January 2019

Structure and chemical composition of coconut shell carbon with polyvinyl alcohol (PVA) as the stimulant through the observation of TG-DTA, SEM-EDS and FTIR has been studied. The process was carried out by calcining coconut shell charcoal at the temperature of 873 and 1023 K under Nitrogen flow, then mixed with polyvinyl alcohol (PVA) under composition of 2.5 to 7.5% (wt) in water solvent. The growing of carbon composite structure was observed by heating the samples in Argon gas of 1673 K, the rate of temperature was 10 K/min in 3 h. The products were then analyzed by TG-DTA, SEM-EDS, FTIR and XRD. The result showed that the products were in uniform particle sizes of micrometer dimensions and spherical particles shape, with average content of C element was 97.44% (wt), aromatic character and semi-crystalline structure.
PREPARATION OF HIGHLY ACTIVE Co-Mo/Al2O3 HDS CATALYSTS WITH CITRIC ACID ADDITION BY THE POST-TREATMENT METHOD
Authors: Rinaldi Nino
Published: January 2019

A study of the influence of citric acid (CA) addition by a post-treatment method during the preparation of a series of Mo/Al2O3 catalysts on the thiophene HDS activity was conducted. The Mo/Al2O3 catalysts were also prepared by a chemical vapor deposition (CVD) technique using Co(CO)3NO to introduce Co atom and characterized by means of NO adsorption, XRD, Mo K-edge EXAFS and XRF. With 8.7 wt% Mo, citric acid was not affected very much for the Co-Mo/Al2O3 catalysts. On the other hand, an outstanding result was shown that the HDS activity was drastically enhanced by 5 times up to Mo content around of 25 wt% Mo. It is suggested that the post treatment increased the dispersion of MoS2 particles, in particular at a high Mo loading. This was also supported by the amount of NO adsorption and amount of Co anchored by the CVD results, which enhanced as the increasing Mo loading up to 25 wt% Mo. Moreover, Mo-CA complex species were observed on the post-treatment method and CVD technique was one of advanced method to prepare Co-Mo-S phases selectively.
QSAR STUDY OF XANTHONE DERIVATIVES AS ANTI PLASMODIAL AGENTS
Authors: Amanatie Amanatie , Jumina Jumina , Mustofa Mustofa , Hanafi M. , Armunanto Ria
Published: January 2019

Xanthones and their derivatives have been reported to exhibit inhibitory activities towards Plasmodium falciparum. To provide deep insight into the correlation between inhibitory activities and structures of xanthones, linear regression method was employed to establish QSAR models for 16 xanthone derivatives that have diverse structures. The accuracy and predictive power of the proposed QSAR model were verified by semi empirical PM3 method, optimation, and validation. The result showed that the best model is model 3 i.e. Log 1/IC50 = Σ (-1.446)qO(7)+ (-8.775)q.C(12) + (-10.592)qC(13) + 1,979; Y = PRESS = 1.124192.
EFFECT OF MALEIC ANHYDRIDE POLYPROPYLENE ON THE PROPERTIES OF COCONUT SHELL FILLED THERMOPLASTIC ELASTOMERIC OLEFIN COMPOSITES
Authors: Faisal Z.H. Tengku , Amri Faisal , Tahir Iqmal
Published: January 2019

Coconut shell (CS) is one of agro-waste material which has high natural lignocellulosics content. This material provides a potential resource as a reinforcement agent in thermoplastic elastomeric olefin (TEO). In this study, CS was used as filler in TEO composites. The effect of CS loading and Maleic Anhydride Polypropylene (MAPP) as compatibilizer on mechanical properties, morphology and thermal properties were studied. Results show that the increasing of CS loading has increased the tensile strength, elongation at break and Young's modulus of TEO/CS composites. At similar content, the effect of PP-g-MA as compatibilizer has improved the tensile strength, elongation at break and Young's modulus of TEO/CS composites. The SEM study of the tensile fracture surface of compatibilized composites indicates that the presence of PP-g-MA increased the interfacial interaction. TGA results show that the composites with addition of MAPP as a compatibilizer has better the thermal stability compared to composites without addition of MAPP at 600 °C. DSC analysis showed that the addition of MAPP decreases the crystallinity of TEO/CS composites. It was found that the presence of MAPP will extended the molecular chain of the TEO/CS composites.   Keywords: thermoplastic olefin, coconut shell, compatibilizer, composites
KINETIC INVESTIGATION OF PROPANE DISAPPEARANCE AND PROPENE FORMATION IN PROPANE OXIDATION ON DILUTED AND LEACHED MoVTeNb CATALYST
Authors: Widi Restu Kartiko
Published: January 2019

Reaction kinetics for the oxidation of propane over diluted-leached MoVTeNb is described. This paper is focused on the study of products selectivity profile and determination of the orders of propane disappearance and propene formation. The result shows that selective oxidation of propane to propene over this catalyst follows the Langmuir-Hinshelwood mechanism. The disappearance of propane is first order with respect to hydrocarbon and partial order (0.21) with respect to oxygen. The propene formation is first order with respect to hydrocarbon and not depending on oxygen concentration.   Keywords: propane oxidation, propane disappearance, propene formation, kinetic, reaction order