bluuebunny/crossref_metadata_2025 huggingface dataset:
PROSPeCT: A Predictive Research Online System for Prostate Cancer Tasks
Authors: Cutumisu Maria , Vasquez Catalina , Uhlich Maxwell , Beatty Perrin H. , Hamayeli-Mehrabani Homeira , Djebah Rume , Murtha Albert , Greiner Russell , Lewis John D.
Published: May 2019

PURPOSE

An online clinical information system, called Predictive Research Online System Prostate Cancer Tasks (PROSPeCT), was developed to enable users to query the Alberta Prostate Cancer Registry database hosted by the Alberta Prostate Cancer Research Initiative. To deliver high-quality patient treatment, prostate cancer clinicians and researchers require a user-friendly system that offers an easy and efficient way to obtain relevant and accurate information about patients from a robust and expanding database.

METHODS

PROSPeCT was designed and implemented to make it easy for users to query the prostate cancer patient database by creating, saving, and reusing simple and complex definitions. We describe its intuitive nature by exemplifying the creation and use of a complex definition to identify a “high-risk” patient cohort.

RESULTS

PROSPeCT was made to minimize user error and to maximize efficiency without requiring the user to have programming skills. Thus, it provides tools that allow both novice and expert users to easily identify patient cohorts, manage individual patient care, perform Kaplan Meier estimates, plot aggregate PSA views, compute PSA-doubling time, and visualize results.

CONCLUSION

This report provides an overview of PROSPeCT, a system that helps clinicians to identify appropriate patient treatments and researchers to develop prostate cancer hypotheses, with the overarching goal of improving the quality of life of patients with prostate cancer. We have made available the code for the PROSPeCT implementation at https://github.com/max-uhlich/e-PROSPeCT .
Essential role of the mouse synapse associated protein Syap1 in circuits for spontaneous motor activity and rotarod balance
Authors: von Collenberg Cora R. , Schmitt Dominique , Rülicke Thomas , Sendtner Michael , Blum Robert , Buchner Erich
Published: May 2019

Synapse-associated protein 1 (Syap1) is the mammalian homologue of synapse-associated protein of 47 kDa (Sap47) in Drosophila. Genetic deletion of Sap47 leads to deficiencies in short-term plasticity and associative memory processing in flies. In mice, Syap1 is prominently expressed in the nervous system, but its function is still unclear. We have generated Syap1 knockout mice and tested motor behaviour and memory. These mice are viable and fertile but display distinct deficiencies in motor behaviour. Locomotor activity specifically appears to be reduced in early phases when voluntary movement is initiated. On the rotarod, a more demanding motor test involving control by sensory feedback, Syap1-deficient mice dramatically fail to adapt to accelerated speed or to a change in rotation direction. Syap1 is highly expressed in cerebellar Purkinje cells and cerebellar nuclei. Thus, this distinct motor phenotype could be due to a so far unknown function of Syap1 in cerebellar sensorimotor control. The observed motor defects are highly specific since other tests in the modified SHIRPA exam, as well as cognitive tasks like novel object recognition, Pavlovian fear conditioning, and anxiety-like behaviour in open field, dark-light transition, and elevated plus maze, do not appear to be affected in Syap1 knockout mice.
Franciszek Batko (1885‑1953): Nauczyciel, żołnierz, sybirak – szkic biograficzny
Authors: Szuster Gabriel
Published: May 2019

Franciszek Batko (1885‑1953): Teacher, Soldier, Survivor of Siberia – A Biographical SketchThis article is a biographical sketch whose purpose is to shed light on the figure of Franciszek Batko (1885-1953). Although he was from Sygneczów outside Wieliczka, he spent his entire adult life in Ochojno in the municipality of Świątniki Górne. First of all, he was a teacher with an academic education; both before and after the Great War he worked as a teacher in the state gymnasiums. In 1914, he was conscripted into the Austrian army. Upon completion of officer training in Styria, he was sent to the front. In 1915, he was taken hostage by the Russians; at that point, his long sojourn as an exile to Siberia and soldier of the Polish 5th Siberian Rifle Division began. Thanks to his courage and shrewdness, he returned to Poland in 1921. Thank he took on the duties of a teacher once again. During the Second World War, he participated in the struggle against the Germans. He received many decorations, including the Cross of Valor and the Cross of Independence. Batko is buried in Podstolice.
Pogrzeb Wojciecha Korfantego w świetle wybranych tytułów prasowych
Authors: Paluch Filip
Published: May 2019

Wojciech Korfanty’s Funeral in Light of Selected Press TitlesThe funerals of political activists from the generation of the fathers of Polish independence were considered to be events of great socio‑political significance in the final years of the Second Polish Republic. The funeral ceremonies were placed within the context of growing war‑related tensions and the internal political situation in the country; frequently, they were of a performative nature, affirming the community of a given political milieu as well as, as in the case of the funeral of Józef Piłsudski, the civic community of the Polish state. An event that partly due to the outbreak of World War II has not endured in collective memory is the funeral of Wojciech Korfanty. While analyzing the social reception of the mourning ceremonies related to the politician’s sudden death, the author has made use of seven press titles that represented a reliable spectrum of opinions expressed by the nation’s political milieus. The aim of this article is to present and analyze the discourse that took place in selected press titles in relation to the death of Wojciech Korfanty, the initiator of the Third Silesian Uprising.
Wspomnienia młodości. Służba w Legionach (fragment)
Authors: Bielski Tadeusz Saryusz
Published: May 2019

Wybrał i wstępem poprzedził Andrzej Dróżdż
MEMES, RACISMO E EDUCAÇÃO, OU POR QUE OS MEMES DA TAÍS ARAÚJO IMPORTAM
Authors: Cardoso Junior Leonardo Fraga , De Jesus Oliveira Kaio Eduardo , Porto Cristiane De Magalhães
Published: May 2019

Este artigo tem como objetivo discutir a importância dos memes de redes sociais digitais na Cibercultura e como eles favorecem a reprodução de discursos racistas na internet. Para isso,   tomou-se como objeto o caso dos memes racistas que tencionam o debate sobre racismo a partir da fala da atriz brasileira Taís Araújo em uma edição do TEDx Brasil. A produção de memes articuladas a este caso específico, insere os usuários no debate sobre preconceito social e racial no Brasil a partir de uma fala própria que se expande na rede, especialmente permeada pelo humor e pela sátira de cada meme, mas é ampliada a partir do contexto ético e moral que toma a repercussão. Utiliza-se como método a pesquisa qualitativa, de cunho exploratório e descritivo. Ao final, evidencia-se que os memes racistas presentes nas redes sociais fortalecem o racismo no debate público, visto que ampliam por meio do conteúdo irônico e superficial deste memes propriamente, um discurso que não remete ao sentido original do fato, mas que ganha dimensões hiperbólicas em sentidos distintos na rede e na produção de sentidos e subjetividades dos indivíduos imersos na rede.
Memes de internet nas aulas de Língua Portuguesa: algumas alternativas para o estudo do gênero
Authors: Berger Isnalda , Anecleto Úrsula Cunha
Published: May 2019

Este trabalho tem como objetivo discutir sobre memes de internet enquanto gêneros textuais híbridos que circulam em novas esferas públicas, a partir das Tecnologias da Informação e Comunicação e analisar alternativas de estudo dos memes nas aulas de Língua Portuguesa da educação básica. Ancora-se nos estudos sobre memes (RECUERO, 2009); esfera pública (HABERMAS, 1997) e gêneros textuais híbridos (SANTAELLA, 2014). Reforçamos que, enquanto textos sócio-historicamente situados, os memes de internet, além de contribuir para a difusão de informações no espaço virtual, oportuniza a formação de opiniões e a promoção de debates nas salas de aula da educação básica, estimulando de maneira criativa a atuação de estudantes em esferas públicas digitais.
MULTIMODALIDADE E EFEITOS DE SENTIDO NO GÊNERO MEME
Authors: Cani Josiane Brunetti
Published: May 2019

Considerando a importância de compreender a natureza constitutiva dos gêneros influenciada pelos recursos tecnológicos digitais, este trabalho tem como objetivo discutir a multimodalidade presente no gênero meme. A partir de uma análise multimodal à luz dos pressupostos teóricos abordados por Jewitt e Hiippala, apresentam-se alguns memes coletados no Facebook, estabelecendo uma taxonomia desses autores para a análise da multimodalidade relacionada aos principais usos desse gênero como dinâmica social. Utiliza-se uma abordagem qualitativa, abrangendo aspectos da linguagem visual e verbal, bem como elementos interativos de comunicação social. A análise permitiu concluir que as representações semióticas desses textos, facilmente replicáveis, seja por meio de crítica, humor ou carga emocional, promovem impactos nas práticas sociais.
Educação Museal na Cibercultura: o uso de memes no projeto “Clube de Jovens Cientistas” da Seção de Assistência ao Ensino (SAE) do Museu Nacional/UFRJ
Authors: Marti Frieda Maria , Costa Andrea , Miranda Aline
Published: May 2019

Este artigo tem como foco a interface entre cibercultura e educação museal. Objetivamos narrar a experiência de criação de memes por estudantes durante uma atividade educativa da Seção de Assistência ao Ensino do Museu Nacional (MN), discutir os possíveis conhecimentossignificações que emergiram a partir destas autorias e as potencialidades educativas dos memes na educação museal. Descrevemos uma oficina realizada com 23 estudantes do Ensino Fundamental I de escolas públicas municipais do Rio de Janeiro, participantes do projeto “Clube de Jovens Cientistas”. Após visitarem as exposições do MN em pequenos grupos e, considerando a sua interação com os objetos, os estudantes elaboraram 20 memes com tablets e acesso à wi-fi disponibilizados pelo Museu. Os 10 memes aqui discutidos nos fizeram observar a forte relação dos educandos com o gênero textual em questão. A produção textual dos memes se mostrou multimodal e indicou uma produção de sentidos baseada nos contextos sociais e históricos vivenciados pelos seus autores, nos auxiliando, dessa forma, a refletir sobre o contexto da educação museal na cibercultura e a relação entre ciência e sociedade.
Prevalência de sintomas depressivos no idoso hospitalizado: estudo comparativo
Authors: Serra Marcela Araujo , Nascimento Isabela Maria Tavares do , Guimarães Gilberto De Lima , Silva Silmar Maria da , Goveia Vania Regina , Mendoza Isabel Yovana
Published: May 2019

Objetivo: Comparar a prevalência dos sintomas depressivos no idoso hospitalizado, mediante uso da Escala de Depressão Geriátrica–15 e por meio da avaliação realizada pelo enfermeiro na admissão do idoso.  Método: Estudo descritivo de abordagem transversal em hospital público de ensino. Utilizou-se a Escala de Depressão Geriátrica e instrumento com lista de sintomas depressivos, extraídos das características definidoras dos diagnósticos de enfermagem. Resultados: A prevalência de sintomas depressivos em idosos hospitalizados foi de 47%, segundo a Escala de Depressão Geriátrica, e de 25% segundo a avaliação do enfermeiro, no momento da admissão do paciente. Conclusão: A avaliação realizada pelo enfermeiro detectou baixa porcentagem dos sintomas depressivos no idoso em comparação ao instrumento específico para depressão.
Recursos humanos e materiais para prevenção de lesão por pressão
Authors: Tonole Renato , Brandão Euzeli
Published: May 2019

Objetivo: Refletir acerca da importância dos recursos humanos e materiais na perspectiva da prevenção de lesão por pressão. Conteúdo: Trata-se de um estudo de reflexão pautado na literatura cientifica e de políticas públicas recente relacionada ao tema. Apesar da disponibilidade de escalas de avaliação de risco do cliente, as condições do cenário em que o mesmo está inserido muitas vezes não são favoráveis para realização dos cuidados de forma efetiva e individualizada. Dependendo das condições estruturais, o risco do cliente pode ser potencializado pela falta de recursos humanos e materiais.  Conclusão: Os recursos humanos e materiais são imprescindíveis na realização das intervenções direcionadas para prevenção de lesão por pressão. A disponibilidade de um instrumento para avaliação de tais recursos poderá contribuir para caracterizar o cenário onde o cliente está inserido, avaliando se os recursos disponíveis podem prestar uma assistência segura e livre de danos.
Managing radicalised patients in healthcare: raising questions for future service development
Authors: Hussain Feryad A , Royan Lindsay
Published: May 2019

Today, there are an ‘increasing number of radicalised ‘returnees’ coming home after being involved in fighting abroad. While the issue of radicalisation has existed for a number of decades, the UK faces a growing problem of managing people who have been exposed to radical beliefs. The literature has identified a number of common, contributory factors that are rooted in psychosocial issues. To this effect, health and social care services are being asked to offer therapeutic interventions and support, while working together with legal teams and police departments in order to develop a suitable preventative/management strategy. This article has been borne out of a specific project of one such team. It considers the professional challenges that teams face in applying existing models of service delivery to a new and emerging area of healthcare. An alternative working model is suggested for the development of future services.
The experience of NHS care for women living with female genital mutilation
Authors: Ormrod Judith
Published: May 2019

This qualitative study aims to explore and analyse the experiences of women living with female genital mutilation (FGM) who have sought help from healthcare providers within the NHS. Nine women aged 20–46 years were recruited from support organisations in the north-west of England and interviewed about their experiences of NHS care and if any screening had taken place in relation to the consequences of living with FGM. The interviews were undertaken in English, audiotaped, transcribed and analysed using a framework analysis method. Eight of the women had given birth and the main contact with the NHS had been with midwifery, gynaecology and paediatric services. Three key themes emerged from the qualitative data: involvement with healthcare professionals; silent suffering; and compassionate communication. Findings highlight the importance of sensitive and culturally competent communication nurses require to support women and refer them to appropriate services.
Pain management in new amputees: a nursing perspective
Authors: Colquhoun Liz , Shepherd Val , Neil Michael
Published: May 2019

Phantom limb pain (PLP) is a widespread and challenging neuropathic pain problem, occurring after both surgical and traumatic amputation of a limb. It may occur immediately after surgery or some months later, however, most cases it presents within the first 7 postoperative days. Patients report a range of pain characteristics in the absent limb, including burning, cramping, tingling and electric shock sensation. The incidence of PLP has been reported to be between 50% and 85% following amputation. Its management is notoriously difficult, with no clear consensus on optimal treatment. It is often resistant to classic balanced analgesia and typical neuropathic pain medications. Taking into account these issues, the authors aimed to improve the management of patients undergoing amputation at their institution, by ensuring accurate and holistic assessment, the selection of suitable interventions through critical analysis and synthesis of available evidence, and the appropriate evaluation and adaptation of treatment plans, to ensure patients achieved their individualised goals.
Have CQC hospital inspections resulted in better quality care?
Authors: Glasper Alan
Published: May 2019

Emeritus Professor Alan Glasper, University of Southampton, discusses the impact and success of Care Quality Commission hospital inspections since publication of the report into Mid Staffordshire NHS Trust
Patient safety: the need for global sharing and learning
Authors: Tingle John
Published: May 2019

John Tingle discusses some patient safety perspectives from around the world
Retaining nurses past retirement
Authors: Foster Sam
Published: May 2019

Sam Foster, Chief Nurse, Oxford University Hospitals, reflects on the opportunities to retain experienced staff and the importance of well-thought-out organisational approaches and clear communication around this issue
How specialist palliative care nurses identify patients with existential distress and manage their needs
Authors: Fay Zara , OBoyle Colm
Published: May 2019

Background:

Existential distress is a term used when patients who are coming towards the end of their lives exhibit profound suffering, related particularly to their thoughts on life and existence. The clinical expression of this phenomenon has not been widely researched, and so specialist palliative care nurses were asked how they identify and manage this patient cohort.

Aims:

To explore how palliative-care nurses identify patients with existential distress and manage their needs.

Methods:

A qualitative descriptive design with thematic content analysis of transcribed interviews.

Findings:

Behavioural changes, agitation, social withdrawal and communication difficulties are identified as indicators of possible existential distress. Susceptible patient groups are identified. Nurses acknowledged that caring for patients with existential distress can be emotionally demanding. Being present and building relationships with patients are identified as enabling meaning-making. Sedation for refractory distress is seen as a last resort.

Conclusion:

Early identification of existential distress by carers could enable timely intervention (counselling, psychotherapy and or spiritual guidance) to improve the patients' quality of life in the terminal phase of their illness and avoid intractable or refractory existential distress that may necessitate palliative sedation.
Research roundup
Authors: Heggs Karen
Published: May 2019

Synopses of a selection of recently published research articles of relevance to palliative care
Awareness, involvement and detachment: Understanding McLuhan’s notions of the subliminal, Narcissus narcosis, figure/ground and the anti-environment
Authors: Logan Robert K.
Published: May 2019

Use is made of Daniel Lewis’s idea that ‘awareness depends not only on involvement, but detachment as well’ to better understand McLuhan’s notion of the following ideas: the subliminal effects of media and technology, Narcissus narcosis, figure/ground and the relationship of environment and anti-environment.
Prevalence, molecular typing, and antimicrobial resistance of bacterial pathogens isolated from ducks
Authors: Eid Hamza M. , Algammal Abdelazeem M. , Elfeil Wael K. , Youssef Fatma M. , Harb Sawsan M. , Abd-Allah Ehab M.
Published: May 2019

Aim: This study aimed to investigate the prevalence of different bacterial species affecting ducks as well as demonstrating the antimicrobial susceptibility and molecular typing of the isolated strains.

Materials and Methods: A total of 500 samples were randomly collected from different duck farms at Ismailia Governorate, Egypt. The collected samples were subjected to the bacteriological examination. Polymerase chain reaction (PCR) was applied for amplification of Kmt1 gene of Pasteurella multocida and X region of protein-A (spA) gene of the isolated Staphylococcus aureus strains to ensure their virulence. The antibiotic sensitivity test was carried out.

Results: The most common pathogens isolated from apparently healthy and diseased ducks were P. multocida (10.4% and 25.2%), Escherichia coli (3.6% and 22.8%), Staphylococcus epidermidis (10% and 8.8%), Pseudomonas aeruginosa (2% and 10%), and Proteus vulgaris (0.8% and 10%), respectively. In addition, S. aureus and Salmonella spp. were isolated only from the diseased ducks with prevalence (12.2%) and (2.8%), respectively. Serotyping of the isolated E. coli strains revealed that 25 E. coli strains were belonged to five different serovars O1, O18, O111, O78, and O26, whereas three strains were untypable. Salmonella serotyping showed that all the isolated strains were Salmonella Typhimurium. PCR revealed that four tested P. multocida strains were positive for Kmt1 gene with specific amplicon size 460 bp, while three strains were negative. In addition, all the tested S. aureus strains were positive for spA gene with specific amplicon size 226 bp. The antibiotic sensitivity test revealed that most of the isolated strains were sensitive to enrofloxacin, norfloxacin, and ciprofloxacin.

Conclusion: P. multocida is the most predominant microorganism isolated from apparently healthy and diseased ducks followed by E. coli and Staphylococci. The combination of both phenotypic and genotypic characterization is more reliable an epidemiological tool for identification of bacterial pathogens affecting ducks.
A feladatmegosztás a diszruptív technológiák világában
Authors: Pléh Csaba
Published: May 2019

Cikkemben a kognitív pszichológia szemszögéből tekintem át az IKT-környezetben jelentkező multitaskingról és hatásairól szóló, napjainkban jelentkező vitákat. A nagyobb vizsgálatok azt mutatják, hogy a valós életben a multitasking főleg az időfogyasztás szempontjából bír negatív hatásokkal. Az osztálytermi megfigyelések azt mutatják, hogy a feladatmegosztás csökkenti az olvasási időt, ugyanakkor a diszruptív technológiák elősegítik a társadalmi megerősítést, ami mindenképpen további vizsgálatra érdemes tény. Központi kérdés, hogyan tudjuk az öntudatos felhasználókat megtanítani a hosszabb távú feladattudat fenntartására.
Maternal Behavior Affects Child’s Attachment-Related Cortisol Stress Response
Authors: Köhler-Dauner Franziska , Fegert Jörg M. , Buchheim Anna, , Krause Sabrina , Gündel Harald , Waller Christiane , Waller Christiane , Ziegenhain Ute
Published: May 2019

Background Mothers with a history of childhood maltreatment (CM) are likely to transmit their own experiences to the next generation. This is highly influenced by the quality of maternal behavior that enables to buffer infant’s hypothalamic-pituitary-adrenal (HPA) axis response to stress. From a transgenerational perspective the research question is, if infant’s cortisol stress response is influenced by maternal CM experiences or rather by the behavioral pathways during the first year of life. Methods 53 mother-child-dyads were measured at 12 months of infant’s age in a laboratory visit assessing the maternal quality of interactive behavior using the Atypical Maternal Behavior Instrument for Assessment and Classification (AMBIANCE) measured during the strange situation procedure (SSP). Maltreatment experiences were assessed using the childhood trauma questionnaire (CTQ). Salivary cortisol of mother and infant were collected prior to and directly, 15 and 30 minutes after the SSP. Results Infants of disruptive mothers showed a significant increase in cortisol (F (3; 147) = 2.897, p= 0.048) after the SSP compared to infants of mothers with sensitive caregiving. Maternal CM did not influence the infant’s cortisol stress response due to the SSP. However maternal cortisol response was altered by trend due to CM (F (1.392; 71.008) = 3.157, p= 0.066). Conclusions Our data indicate that infant’s cortisol stress reactivity is influenced by the quality of maternal behavior and not by the transgenerational transmission of maternal CM experiences per se. These findings implicate that helping mothers to improve their caregiving behavior may help to improve stress-reactivity of their infant.
“Eu comecei a dar uma aula mais biológica mesmo, porque é bem polêmico”: currículo de Ciências e Biologia e os atravessamentos de diversidade sexual e de gênero
Authors: Castro Roney Polato de , Reis Neilton dos
Published: May 2019

O artigo se propõe a problematizar os atravessamentos entre educação em Ciências e Biologia e a abordagem das diversidades sexuais e de gêneros na escola. Tomamos como base as análises produzidas em uma pesquisa com professoras de Ciências e Biologia sobre gêneros não-binários. As análises inspiram-se nos estudos pós-críticos, que nos possibilitam lidar com as ciências, a educação, os gêneros e sexualidades como categorias históricas, sociais e culturais, constituídas nos jogos de poder e de linguagem. Sobretudo, direcionamos nosso olhar para currículos e conteúdos curriculares: tanto os forjados na cisheteronormatividade, que assumem narrativas científicas e ditas neutras, quanto os que desestabilizam conhecimentos e práticas normativas e anunciam outras relações, gêneros e sexualidades. Apostando no questionamento e na provocação, arriscamo-nos a ensaiar possibilidades para pensar as relações entre os currículos de ciências e biologia, as narrativas acerca dos gêneros e das sexualidades e a produção de experiências de estudantes e docentes.  

PALAVRAS-CHAVE: Educação em Ciências e Biologia; Diversidade sexual e de gênero; Currículo.
Waiting for Peace in Prayers of Jews and Christians as an Example of Definition of Identity
Authors: Luccio Pino di
Published: May 2019

En estas páginas presento el significado bíblico de la paz y propongo que en el Evangelio de Mateo la petición para la remisión de las deudas del Padre Nuestro especifica una característica de la paz. Acto seguido, explico el significado de la paz en el Benedictus, y presento ejemplos de oraciones del Segundo Templo para ilustrar la variedad de los significados de la paz entre los grupos judíos de esta época. A continuación, presento el significado de la paz en algunas oraciones hebreas (de la sinagoga), sugiriendo las razones por las que es posible suponer que, en algún caso, a través de la petición de la paz, es diferenciada intencionadamente la identidad religiosa de aquellos que recitan estas oraciones de la identidad de quien recita el Padre Nuestro y el Benedictus.
¿Identidad cristiana étnica? El caso de Diogn. 1.1
Authors: Chapa Juan
Published: May 2019

El carácter étnico del cristianismo primitivo es un tema debatido en la actualidad. La referencia a γένος presente en el comienzo de la Carta a Diogneto es aducida con frecuencia para defender una comprensión racial/étnica de la identidad cristiana. Para algunos autores esta interpretación se apoya en las referencias a la expresión «tercer γένος/genus» que se encuentra en otros escritores cristianos anteriores o contemporáneos a Diogn. El presente trabajo aboga por una interpretación no étnica del término, analizando el significado de γένος en combinación con ἐπιτήδευμα, la palabra que le sigue unida por ἢ. Mediante ejemplos tomados de la literatura griega clásica y cristiana, se sostiene que con τοῦτο γένος ἢ ἐπιτήδευμα el autor de la carta se está refiriendo principalmente al modo de vida de los cristianos en la sociedad en que habitan sin connotaciones étnicas.
Pour une approche documentaire des paroles de Jésus
Authors: Amphoux Christian-Bernard
Published: May 2019

---
Recent Trends in the Textual Criticism of the New Testament. A New Millenium, a New Beginning?
Authors: Elliott James Keith
Published: May 2019

---
Anthroponymie iranienne dans la plaine hyrcanienne. Un outil pour étudier la colonisation achéménide ?
Authors: Bouzid-Adler Fabrice
Published: May 2019

---
Some Aspects of the Religious Organization of St. Thomas Christians during the Pre-colonial Period
Authors: Durant Thomas
Published: May 2019

---
« Car tout [homme] au feu sera salé ». Un réexamen textuel de Marc 9,49
Authors: Wauters Audrey
Published: May 2019

---
La linguistique marriste et son onomastique. Le cas de la Géorgie
Authors: Van Elverdinghe Emmanuel
Published: May 2019

---
À propos de deux passages du Grand Hymne à Aton (colonnes 2-3 et 6-7)
Authors: Obsomer Claude
Published: May 2019

---
Continuity of some Nabataean legal practices during the Late 19th - Early 20th century: a study in the light of unpublished deeds of sale from Wādī Mūsā, southern Jordan
Authors: Al-Salameen Zeyad , Falahat Hani
Published: May 2019

---
Guerres et discours sur la guerre dans la propagande royale: le monde ouest-sémitique au Ier millénaire av. J.-C.
Authors: Daccache Jimmy
Published: May 2019

---
Sephardic Hebrew Bibles of the Kennicott Collection
Authors: Ortega-Monasterio M. Teresa
Published: May 2019

---
Les versions syriaques des Discours de Grégoire de Nazianze : un processus continu de révision
Authors: Haelewyck Jean-Claude
Published: May 2019

---
La concordance bilingue grecque-syriaque des Discours de Grégoire de Nazianze
Authors: Kindt Bastien , Haelewyck Jean-Claude , Schmidt Andrea , Atas Nicolas
Published: May 2019

---
La troisième statue de Sésostris III au musée de Khartoum
Authors: Obsomer Claude
Published: May 2019

---
The Pericope Adulterae and the Golden Calf: A Case for Intertextuality between Codex Bezae and the Jewish Scriptures
Authors: Pinchard Laurent
Published: May 2019

---
New Potential Nonsteroidal Anti-Inflammatory Drugs with Antileukotrienic Effects: Influence on Model Proteins with Catalytic Activity
Authors: Netopilová Miloslava , Dršata Jaroslav , Beránek Martin , Palička Vladimír
Published: May 2019

Unspecific and side effects caused by interaction with proteins belong to common problems of many structures synthesized as potential medicaments. Possible in vitro interactions with proteins of a group of phenylsulfonyl benzoic acid derivatives (VÚFB 19363, 19369, 19370, 19371, and 19760) as new potential anti-inflammatory compounds with antileukotrienic activities were studied in the present work. Three purified enzymes were used as model proteins with catalytic activities: Pig heart aspartate aminotransferase (AST, EC 2.6.1.1), alanine aminotransferase (ALT, EC 2.6.1.2), and glutamate decarboxylase (GAD, EC 4.1.1.15) from E. coli. Catalytic activities during incubation of individual compounds (6 x 10-5 M solution to 5 x 10-2 M suspension) at 37 °C with enzymes served as criteria of stability and function of the proteins. No immediate influence of any compound studied on enzyme activities was found. Aminotransferase activities were not affected even during incubation up to 20 d. In the case of GAD, the compounds VÚFB 19369, 19370, 19371, and 19760 had stabilizing influence on GAD activity during incubation at enzyme concentrations of 11.25 and 5.62 mg prot/l. The lack of an immediate effect of compounds and the stability of enzymes during incubation them are favorable and support the prospective of the compounds as potential drugs.
Triglycerides Predict Plasma Fibronectin in Children with Type I Diabetes Mellitus Rather than Diabetes
Authors: Erbağcı Ayşe Binnur , Tarakçıoğlu Mehmet , Erbağcı Ahmet , Gözübüyük Mehmet , Yılmaz Necat , Deveci Rukiye , Kocabaş Ramazan
Published: May 2019

Fibronectins are adhesive proteins considered as markers of endothelial activation. Plasma fibronectin levels in diabetes mellitus (DM) have been found to be associated with atherosclerotic risk factors. This study was carried out to investigate plasma fibronectin and its relation with serum lipids, apolipoproteins AI, B100 and lp(a) in diabetic children. 35 children (19F/16M) with type I DM and 30 non-diabetic age and gender-matched controls were enrolled. Apolipoprotein and fibronectin concentrations were determined with nephelometric methods. Plasma fibronectin levels of the children with type I DM and the control group are not statistically different. HbA1c and triglycerides concentration are found to be significant predictors of plasma fibronectin in diabetic children, while effect of plasma cholesterol, apolipoprotein AI, B100 and lp(a) are insignificant. Diabetic children with triglycerides 1.13 mmol/l have elevated plasma fibronectin (median, 25th–75th percentiles; 29.6, 8.3–40.8 mg/dL) compared to the diabetic ≥19.9, 8.6–30.7 mg/dL, p<0,05) and non-diabetic children (16.6, 12.7–32.4 mg/dL, p<0.01) with triglycerides<1.13mmol/L. On the other hand plasma fibronectin concentrations of diabetic and non-diabetic children with high triglycerides are not significantly different. In conclusion our data does not support the concept that plasma fibronectin is elevated in type I diabetes mellitus at least in children, but high plasma triglycerides secondary to diabetes or not is associated with higher FNp concentrations which may have implications on atherogenesis. Plasma cholesterol, apolipoproteins AI, B100 and lp (a) are not significant determinants of FNp in type I diabetic children.
Globalizacja a europejski samorząd terytorialny
Authors: Pokładecki Jacek
Published: May 2019

Procesy globalizacyjne, szczególnie nasilone na przełomie XX i XXI wieku, mające głównie charakter gospodarczy i kulturowy, wywierały i wywierają istotny wpływ na funkcjonowanie państw demokratycznych, w tym także na władze lokalne, co wiąże się z dynamicznie zachodzącymi zmianami w ich otoczeniu. Załamanie się modelu państwa opiekuńczego postawiło przed samorządem terytorialnym w Europie nowe wyzwania. W praktyce w wielu państwach europejskich oznaczało to podjęcie reform zmierzających do dewolucji państwa, której osią jest upodmiotowienie społeczności terytorialnych. Głównym efektem globalizacji w obszarze europejskiego samorządu terytorialnego, obok reform struktury przestrzennej oraz zmian instytucjonalnych, jest poszukiwanie adekwatnych systemów zarządzania administracją publiczną, co zawiera się w dwóch procesach: urynkowieniu działalności publicznej oraz dążeniu do jej uspołecznienia.
Lokalne czasopisma Patriotycznego Ruchu Odrodzenia Narodowego w poznańskiem w latach 1983–1989
Authors: Kowalczyk Ryszard
Published: May 2019

Autor scharakteryzował przykładowe czasopisma Patriotycznego Ruchu Odrodzenia Narodowego (PRON), jakie ukazywały się w dawnym województwie poznańskim w latach 1983–1989. Należały do nich następujące miesięczniki: „Echa Opalenickie” (1983–1989), „Głos Śremski” (1984–1989), „Kórniczanin (1988–1989), „Wiadomości Grodziskie” (1986–1989), „Wiadomości Nowotomyskie” (1986–1989), oraz dwumiesięcznik „Ziemia Szamotulska (1988–1989). Przedstawił inicjatorów tych wydawnictw oraz ich cele, zadania i zawartość, a także niektórych autorów materiałów prasowych.
Strukturalne i jakościowe przemiany w mediach lokalnych
Authors: Jurga-Wosik Ewa
Published: May 2019

Zwrócenie uwagi na media lokalne jest ważne z powodu ich tematycznej bliskości z odbiorcą. Występują najczęściej w czterech głównych typach formatu: tradycyjna prasa drukowana, radio lokalne, telewizja lokalna i ortale internetowe. Przeważają ilościowo w wielu systemach medialnych państw (np. tradycyjna prasa drukowana: w Polsce 2000–2500 tytułów, Niemczech – 1500; np. lokalna prasa w wydaniu cyfrowym: Portugalia – 170 tytułów) odgrywając przy tym istotną rolę w życiu społeczeństw. Z empirycznych badań Anny Przybylskiej wynika, iż regularny kontakt z mediami lokalnymi wpływa pozytywnie na przywiązanie do miejsca zamieszkania i zaangażowanie społeczne mieszkańców. Celem niniejszego artykułu jest przedstawienie problemów, na jakie napotykają polskie media lokalne i kierunków ich rozwoju. Hipoteza badawcza brzmi – przemiany w polskich mediach lokalnych dotyczą zmian strukturalnych i jakościowych. Zmienia się zatem i warsztat dziennikarza, jak i zawartość prasy lokalnej. Jedną z głównych przyczyn tych zmian jest dynamiczny rozwój technologii. Stąd można zadać pytanie o kierunek tych przekształceń i jakie skutki za sobą pociągają, i wreszcie jaką nową jakość w dziennikarstwie lokalnym wprowadzają.
Polscy seniorzy – wyzwanie dla marketingu w XXI wieku
Authors: Kaniewska-Sęba Aleksandra
Published: May 2019

Prognozy dotyczące struktury wiekowej polskiego społeczeństwa jednoznaczniewskazują, że Polska już niedługo będzie krajem ludzi starych (chyba, że zmieni to fala imigrantów, którzy zaczną uzupełniać braki na rynku pracy w Unii Europejskiej). Ten trend demograficzny niesie zapowiedź wielu zmian na poziomie państwa (np. destabilizacja systemu emerytalnego), rodziny (np. opieka nad najstarszymi członkami rodziny) oraz jednostki (podwyższenie wieku emerytalnego). Jest postrzegany jako wyzwanie w różnych sferach życia społeczno-gospodarczego – nie tylko dla polityki gospodarczej, społecznej, ale także dla firm i organizacji, które kierują swoje produkty i usługi do seniorów. Przedmiotem artykułu będą rozważania na temat osób starszych jako grupy konsumentów, a przede wszystkim – odbiorców działań reklamowych. Ukazane zostaną trendy demograficzne, sytuacja ekonomiczna, zmiany zachodzące w stylu życia i zachowaniach nabywczych polskich seniorów. Na tym tle zaprezentowane zostaną wnioski wynikające z analiz polskich reklam z udziałem osób starszych, kierowanych do tego segmentu lub szerszego rynku odbiorców.
A clinical trial protocol to evaluate the safety and pharmacokinetics of subcutaneously administered immunoglobulin in patients with primary immunodeficiency
Authors: Vong Linda
Published: May 2019

This protocol is excerpted from recent clinical trials used to study the pharmacokinetics, safety, and tolerability of subcutaneously administered immunoglobulin (SCIG) in subjects with primary immunodeficiency. The primary objective is to determine the weekly dose of SCIG product that produces a steady-state area under the concentration-time curve of total immunoglobulin G level that is non-inferior to that of regularly administered intravenous immunoglobulin (IVIG). We include details of the target population, eligibility criteria, treatment phases, key assessments and procedures, and study analyses. Given that IVIG may be problematic in patients with poor venous access or those who develop systemic adverse effects, among others, the development of SCIG for use in the home setting provides an alternative treatment technique for adults and children with primary immunodeficiency.

Statement of novelty: This protocol describes the main topics found in prospective clinical studies evaluating the safety and pharmacokinetics of SCIG in subjects with primary immunodeficiency.
Macroprolactin: an overlooked reason of hyperprolactinemia
Authors: Muhtaroglu Sabahattin , Barlak Keti Didem , Hacıoglu Ayşa
Published: May 2019

Background

Immunoassays show variability in the detection of macroprolactin. The aim of this study was to detect the frequency of macroprolactinemia in hyperprolactinemic patients and the problems encountered in routine clinical practice.

Methods

The screening of macroprolactinemia was performed by precipitation with polyethylene glycol (PEG) in 900 patient samples with hyperprolactinemia over a period of approximately 6 months. Recovery values of less than 40% and greater than 60% were considered as macroprolactinemia and predominantly monomeric prolactin (PRL), respectively.

Results

A total of 900 (17.9%) of the 5007 PRL results were out of reference range. Thirty-one (3.4%) of the patients had less than 40% recovery after screening of all patients with hyperprolactinemia. However, the macroprolactin test was requested by clinics from only 171 patients and seven of these patients had less than 40% recovery. We also detected predominantly macroprolactin in 24 samples, overlooked in routine practice. The patients with PRL above 100 ng/mL had no macroprolactinemia.

Conclusions

The screening for macroprolactinemia of hyperprolactinemic patients who have <100 ng/mL and also with unexplained hyperprolactinemia should be the first approach before any further research or treatment is initiated. Thus, unnecessary test repetition, investigation and inappropriate treatment can be avoided. Each laboratory should inform clinicians about the frequency of macroprolactinemia.
Performance Evaluation of Ant Lion Optimizer–Based PID Controller for Speed Control of PMSM
Authors: Soundirarrajan Navaneethan , Srinivasan Kanthalakshmi
Published: May 2019

A Permanent Magnet Synchronous Motor (PMSM) is dominantly used in applications like electric vehicles, rolling mills, and servo drives. In order to efficiently run PMSM in drive applications, it needs a control strategy. A Proportional-Integral-Derivative (PID) controller is widely used in control loops to perform the automation process. The PID parameters can be tuned using optimization techniques to get a better performance. Upon advancement in computing techniques, it has become simpler to employ complex algorithms for control applications. One such stochastic optimization algorithm is Ant Lion Optimization (ALO). Its performance has been proven against a few other established algorithms of the same kind for a particular set of test functions. In this article, ALO is used to tune a PID controller for speed control of PMSM. The effectiveness of the optimizer is verified with simulation and experimental results.
Critical Analysis of Particle Detection Artifacts in Synaptosome Flow Cytometry
Authors: Hobson Benjamin D. , Sims Peter A.
Published: May 2019

Flow cytometry and fluorescence-activated sorting are powerful techniques that hold great promise for studying heterogeneous populations of submicron particles such as synaptosomes, but many technical challenges arise in these experiments. To date, most flow cytometry studies of synaptosomes have relied on particle detection using forward scatter (FSC) measurements and size estimation with polystyrene (PS) bead standards. However, these practices have serious limitations, and special care must be taken to overcome the poor sensitivity of conventional flow cytometers in the analysis of submicron particles. Technical artifacts can confound these experiments, especially the detection of multiple particles as a single event. Here, we compared analysis of P2 crude synaptosomal preparations from murine forebrain on multiple flow cytometers using both FSC-triggered and fluorescence-triggered detection. We implemented multicolor fluorescent dye-based assays to quantify coincident particle detection and aggregation, and we assessed the false colocalization of antigens in immunostaining analyses. Our results demonstrate that fluorescence triggering and proper dilution can control for coincident particle detection, but not particle aggregation. We confirmed previous studies showing that FSC-based size estimation with PS beads underestimates biological particle size, and we identified pervasive aggregation in the FSC range analyzed in most synaptosome flow cytometry studies. We found that analyzing P2 samples in sucrose/EDTA/tris (SET) buffer reduces aggregation compared to PBS, but does not completely eliminate the presence of aggregates, especially in immunostaining experiments. Our study highlights challenges and pitfalls in synaptosome flow cytometry and provides a methodological framework for future studies.
Inﬂuencia de los patrones de uso de la tierra en la calidad de las aguas superfciales de la subcuenca del río Virilla, Costa Rica
Authors: Herrera-Murillo Jorge , Anchía-Leitón Deivis , Rojas-Marín José Félix , Mora-Campos Diana , Gamboa-Jiménez Alejandra , Chaves-Villalobos María
Published: May 2019

Se analizó la relación existente entre los patrones de uso de la tierra y la calidad química de los cuerpos de agua superfcial que conforman la subcuenca del Río Virilla, Costa Rica. Para ello, se seleccionaron un total de 64 sitios de monitoreo, distribuidos en las 15 microcuencas que la integran, donde se realizaron un total de 04 muestreos, en el período comprendido entre noviembre 2014 a diciembre 2015. A las muestras recolectadas se les analizaron los siguientes parámetros: Potencial de Hidrogeno (pH), conductividad, turbiedad, sólidos suspendidos totales (SST), sólidos sedimentables, Demanda Bioquímica de Oxigeno (DBO), Demanda Química de Oxigeno (DQO), amonio (NH4+), nitrito (NO2-), nitrato (NO3-), nitrógeno total, cloruro (Cl-), sulfato (SO42-), sodio, calcio, potasio, magnesio, aluminio, hierro, manganeso, cobre, cromo, níquel, zinc, plomo, fósforo total, oxígeno disuelto y temperatura. El análisis de clúster basado en los resultados de los análisis químicos en las muestras de agua superfcial, evidenció que las 15 microcuencas se pueden agrupar en seis clústers, donde los grupos I-IV mostraron una mayor contribución de contaminantes derivados de la descarga de aguas residuales provenientes de las áreas urbanizadas. El estudio de correlación de Spearman reveló, que con el incremento de la urbanización, la carga contaminante de DQO, DBO, SST, NH4+ y NO2- en los ríos aumentó en comparación con aquellos en donde predomina el uso agrícola de la tierra y los bosques.
Fragmentación y conectividad de la cobertura natural a nivel cantonal en Costa Rica durante los años 2000 y 2015
Authors: Morera_Beita Carlos , Sandoval-Murillo Luis
Published: May 2019

En esta investigación se plantea la formulación de un índice de fragmentación/conectividad que valora la condición de las coberturas naturales a nivel de cantones para Costa Rica, basado en la distribución espacial, considerando las variables: superficie del cantón, la superficie de cobertura natural, el número de fragmentos y distancia de vecindad entre los fragmentos de la cobertura natural, para los años 2000 y 2015. Se utilizaron las imágenes Landsat 7 para el año 2000 y Landsat 8 para el año 2015, donde se derivaron las categorías de uso de la tierra para cada año mediante clasificación supervisada con el software ERDAS y con el ArcMap10.5, se estimaron los índices biométricos usando la ecuación de Vargas (2008), la cual para su aplicación fue modificada. Dentro de los resultados se identificó los cantones que presentan mayor o menor fragmentación y conectividad de su cobertura natural durante el periodo de estudio.
Alternativas en gestión local del riesgo en cantones sin plan regulador: caso de Alajuelita
Authors: Arroyo González Luis Nelson
Published: May 2019

La situación de deterioro ambiental y la ausencia de un plan regulador ha motivado el establecer alternativas de gestión del riesgos a pobladores de algunos vecindarios mediante charlas, capacitaciones, entrega de material informativo y prácticas de campo. Ello ha llevado a la formación de comités de emergencias vecinales, en donde la incorporación de pobladores ha establecido una diferencia sustancial en la identificación, vigilancia y atención de sitios de riesgo, con mejoras evidentes en la organización comunal y el autocuidado.
Creación de mapas acústicos en los cantones de Heredia, Alajuela y Belén, como indicadores de la contaminación sónica.
Authors: Bermúdez-Hidalgo Ligia , Castro Solís José , Vetrani-Chavarría Karla , Murrell-Blanco Manfred , Barraza Douglas , Méndez-Flores Manuel
Published: May 2019

El presente artículo corresponde a la conformación de mapas acústicos basados en la toma de datos de ruido en los cascos urbanos de los cantones de Heredia, Alajuela y Belén en Costa Rica. Para estose realizó un muestreo, utilizando sitios de denuncia por contaminación sónica en Alajuela y Belén, mientras que en Heredia se utilizaron los vértices de cada uno de los cuadrantes que conforman eldistrito Central como sitio de muestreo. El resultado más importante obtenido en este estudio está referido a la identificación en su mayoría de sitios con niveles de ruido que sobrepasan los límitespermisibles establecidos en el Reglamento de control de ruido que se pueden observar gráficamente en los mapas acústicos. Esto lleva a la conclusión de que los mapas acústicos representan unaherramienta fundamental para el control de ruido y planificación de estrategias de mitigación y confinamiento de áreas de impacto por contaminación sónica.