bluuebunny/crossref_metadata_2025 huggingface dataset:
Staphylococcus aureus colonization and periprosthetic joint infection in patients undergoing elective total joint arthroplasty: a narrative review
Authors: de Buys Michael , Moodley Krisantha , Cakic Josip Nenad , Pietrzak Jurek R T
Published: September 2023

Peri-prosthetic joint infections (PJIs) following total joint arthroplasty (TJA) are associated with higher treatment costs, longer hospital admissions and increased morbidity and mortality.

Colonization with Staphylococcus aureus is an independent and modifiable risk factor for PJIs and carriers of S. aureus are ten times more likely than non-carriers for post-operative infections.

Screening and targeted decolonization, vs universal decolonization without screening, remains a controversial topic.

We recommend a tailored approach, based on local epidemiological patterns, resource availability and logistical capacity.

Universal decolonization is associated with lower rates of SSI and may reduce treatment costs.
Classification Of Pistachio Images With The ResNet Deep Learning Model
Authors: Avuçlu Emre
Published: August 2023

Pistachio, which is grown in many parts of the world today, has an important place in the agricultural economy. In order to maintain this economic value, the post-harvest industrial classification process is very important to obtain efficiency from this harvest. In the process of separating pistachios, an efficient classification process is needed in order for different pistachio species to appeal to different markets. For this reason, the classification process of pistachios is very important. In this study, Kirmizi and Siirt pistachio classification with 2148 images was made using ResNet architecture. After the statistical experimental studies, the highest classification accuracy was obtained from fold-1 as 88.5781% and the Accuracy value was 0.86168 after the classification process.
Agricultural and Food Products Sectors During and Post The Covid-19 Pandemic From Consumer Perspective in Türkiye
Authors: Aydın Can Bahar
Published: August 2023

The purpose of this research is to determine and analyze the opinions of consumers in Türkiye on agricultural and food products sectors during and post pandemic, the points they pay attention to while purchasing agricultural and food products, and their degree of satisfaction with their place of living. The main material of the research consists of the data collected by means of an online survey conducted on the consumers (n=1945) living in Türkiye. The data obtained were used to present their socio-demographic structure with frequency distributions. In addition, a chi square test was conducted to analyze the relationship between their opinions on agricultural and food products sectors during and post pandemic and their demographic characteristics. 5-point Likert scale was employed to demonstrate their attitudes and opinions. According to the results of the research, consumers strongly agreed that agricultural and food products’ prices had increased during the pandemic. 61.9% of the consumers strongly agreed that agricultural and food products’ prices had increased during the pandemic. 60.5% of the consumers indicated they wanted to live in a rural area during the pandemic. The relationship between consumers’ opinions on agricultural and food sectors and most socio-demographic characteristics was found to be significant for the period of pandemic and thereafter. This study may be useful in to predict the change of food and agricultural products consumer demand in post-pandemic.
Determination of Yield and Quality Characteristics of Tribenuron Methyl Group Sunflower Genotypes Newly Developed
Authors: Ada Rahim
Published: August 2023

The present study was conducted to determine the yield and quality characteristics of oil sunflower genotypes as candidates for registration under Konya and Karaman conditions, in 4 replications according to the “Random Blocks Trial Design”. The differences between the cultivars used in both locations of the study in terms of the number of days to bloom, the number of days to physiological maturity, the diameter of the tray, the thousand seed weight, seed moisture, seed yield, oil content, and oil yield were found to be statistically significant. The number of flowering days of the genotypes was found to be 64.5-60.8 days (H412; P63LLE113), the number of days to physiological maturity was 113.9-110.3 days (H412; P63LLE113), plant height 169.0-164.6 cm (M94S35; P63LE113), head diameter 20.9-17.3 cm (H412; P63LLE113), thousand-seed weight 60.3-47.4 g (H408; P64LE119), seed moisture 7.8-5.9 % (H408; P63LE113), seed yield 43.6-43.2 t ha-1 (H412; P64LE119), oil content 44.2-41.8 (H412; M94S35), and oil yield 19.2-17.0 t ha-1 (H412; P63LE113). The study showed that high yields could be achieved by using newly-developed hybrid sunflower genotypes in the conditions in the region. According to the averages of the location, it can be argued that the H412 hybrid that has high seed and oil yield can be successfully grown in regional conditions.
AAP Pediatric Coding Newsletter
™ September 2023 Quiz (Online Exclusive)
Authors:   American Academy of Pediatrics
Published: August 2023

Quiz for AAPC Continuing Education Units
Defining and Promoting Pediatric Pulmonary Health: Understanding Sleep and Ventilatory Health
Authors: Williamson Ariel A. , Amin Raouf S. , Meltzer Lisa J. , Laposky Aaron , Fiks Alexander G. , Tapia Ignacio E.
Published: September 2023

Healthy sleep and optimal ventilatory control begin in early development and are crucial for positive child outcomes. This paper summarizes information presented at the Sleep and Ventilatory Control sessions of the National Heart, Lung, and Blood-sponsored 2021 Defining and Promoting Pediatric Pulmonary Health workshop. These sessions focused on pediatric sleep health, screening for sleep health and sleep disorders in primary care using the electronic health record, infant sleep and ventilatory control, and home sleep testing. Throughout this summary, we discuss key gaps in and barriers to promoting sleep and ventilatory health that were identified during the workshop sessions. We conclude with strategies to address these gaps and barriers and directions for future multidisciplinary research, patient care, and training.
Effects of allogeneic blood transfusion on the immunity parameters in recipient rabbits
Authors: Malyuk M. О. , Yehorov O. V. , Kulida M. A.
Published: September 2023

Blood transfusion is always associated with immunological risks. In animals, immune conflicts can occur, because other than erythrocytes and plasma factors, many other antigens (leukocytes, trombocytes) are not accounted for. This publication is focused on morphological changes in blood of recipient rabbits following allogeneic transfusion. Modeling of blood transfusion was performed on five clinically healthy rabbits by intravenous injection of allogeneic whole blood in estimation of 5.5 mL/kg of body weight. The materials for the study were the blood samples, gathered on the 3rd, 7th, and 23th days after the transfusion. We determined that in the organism of the recipient animals, there occurred post-transfusion leukocytosis. Increase in the number of leukocytes in the experimental animals did not exceed the physiological parameters. After whole-blood transfusion, the amount of lymphocytes and granulocytes in the recipient rabbits did not significantly change over 23 days of the experiment. We recorded significant decrease in the amount of monocytes on the 3–23rd day after allogeneic transfusion in the organism of the recipient rabbits. Following the blood transfusion, percentage of T-lymphocytes in the recipient rabbits increased compared with the initial condition on the 3rd and 7th days of the experimental studies, and decreased on the 23rd day. Percentage of B-lymphocytes in the recipient rabbits after the allogeneic blood transfusion increased compared with the initial level, indicating activation of specific immunity. The whole-blood transfusion led to decrease in the percentage of O-lymphocytes in the recipient on the 3rd day of the experiment, and increase on the 7th and 23rd days of the experiment, as compared with the initial condition. The conducted studies of allogeneic transplantation of whole blood demonstrate that whole-blood transfusion entails a cascade of complex immunological reactions in the recipient animals. The prospects for further research are studies of influence of allogeneic transfusion of blood components on the parameters of specific and non-specific links of immunity of the recipient animals.
Más allá de la deserción escolar: Importancia atribuida a la finalización de la educación secundaria en cuatro comunidades educativas chilenas
Authors: Mendoza Lira Michelle , Ballesta Acevedo Emilio
Published: September 2023

Diversos organismos y países se han propuesto como prioridad fomentar que las infancias y las juventudes finalicen su enseñanza secundaria como garantía de equidad. Sin embargo, el valor de la educación se encuentra en cuestionamiento debido a que no asegura oportunidades, aun con los avances actuales en materia de políticas públicas para asegurar el acceso y la permanencia educativa de toda la población. Por esta razón, acercarse a las escuelas y estudiar la relevancia que le atribuyen a la educación resulta fundamental. La presente investigación cualitativa buscó analizar la importancia que le daban cuatro establecimientos públicos en Valparaíso (Chile) al término de cuarto medio (último nivel educativo de la enseñanza secundaria en este país). En cada recinto educativo se entrevistó al equipo directivo, docentes, profesionales de apoyo, estudiantes y sus familias. Se obtuvieron un total de 57 entrevistas. La información fue analizada bajo el análisis de contenido. Los hallazgos revelaron que graduarse de la enseñanza secundaria es trascendental porque: (1) desarrolla y moviliza habilidades, (2) mejora las oportunidades laborales, (3) favorece el acceso a la educación superior, (4) permite elaborar un proyecto de vida feliz y (5) constituye una fuente de autorrealización personal. Estos motivos, en su conjunto, permiten reconocer que la educación todavía es percibida como una herramienta de equidad e inclusión social.
The use of an RP-HPLC-UV method for the analysis of oxcarbazepine in the presence of its preservatives; stability studies and application to human plasma samples
Authors: Fouad Ali , Abdelkhalek Ahmed S. , Elrefay Hisham , Batakoushy Hany A. , Soltan Moustafa K.
Published: September 2023

A simple, sensitive, selective, accurate and precise method was developed and fully validated for determination of oxcarbazepine (OXC) in presence of their preservatives and determination of oxcarbazepine (OXC) in human plasma. A reversed phase liquid chromatography (RP-HPLC) with UV detection techniques were applied for separation and quantification of studied drug OXC. Successful separation of the drug from methyl paraben (M.P.), propyl paraben (P.P.) and potassium sorbate (P.ST.) was achieved on a Kromasil C18 column (5 μm particle size, pore size 300 Å, l × I.D. 250 × 4.6 mm). The mobile phase that contain aqueous 0.05M potassium dihydrogen phosphate buffer (pH 7): acetonitrile, (50: 50, %v/v). The method was linear over concentration ranges 5.0–50 μg mL−1 for OXC. Bioanalytical validation of the developed method was carried out according to US-FDA guidelines and revealed a good linear relations over a range of (5.0–50), (0.5–10), (0.05–0.15), and (1.0–10) μg mL−1 for OXC, M.P, P.P, and P.ST, respectively, with a correlation coefficient (R2) of more than 0.999. Limit of detection (LOD) were 1.15, 0.03, 0.01 and 0.04 μg mL−1 for OXC, M.P, P.P, and P.ST, respectively, Intra and inter-day precisions, calculated as percentage relative standard deviation (% RSD), were lower than 2.0%. The developed method can be applied for routine drug analysis, therapeutic drug monitoring and bioequivalence studies through the analysis of plasma samples taken from blood bank.
Molecular redox-active organic materials for electrochemical carbon capture
Authors: Seo Hyowon
Published: September 2023

This prospective is a forward-looking outlook for researchers investigating electrochemical carbon capture utilizing molecular redox-active organic materials, with the following objectives: (1) identifying the essential components of an electrochemical carbon capture system, (2) introducing design principles for the system utilizing redox-active organic materials, encompassing their physicochemical properties and other critical factors, (3) presenting representative examples, and (4) promoting further experimental and theoretical studies on the application of redox-active organic materials for electrochemical carbon capture.

Graphical abstract
Las facultades literarias del alma y la recepción de la literatura en la Ilustración
Authors: Rodríguez-Sánchez-de-León María-José
Published: August 2023

En este trabajo se estudia la relevancia del término gusto y de otros conceptos asociados (razón, imaginación) en el siglo XVIII. Para ello se comienza por aclarar el proceso que conduce desde un sentido innato a una idea intelectualizada del gusto, que se convierte en una capacidad adquirida de conocimiento y discriminación. Se analiza, en primer lugar, de qué manera los ilustrados teorizaron para fundamentar su origen en la observación de la naturaleza y, al mismo tiempo, para relacionarlo con la imaginación creadora y con la razón o el saber adquirido. En segundo lugar, se estudia el papel atribuido al gusto en la conformación del juicio crítico y, por extensión, en la crítica literaria. Finalmente se estudia el papel desempeñado por la lectura literaria como instrumento educador del gusto a través de las obras literarias y sus relaciones con la materialización formal del discurso y con la idea del placer estético.
Oral food challenge in children with contact urticaria in reaction to cow’s milk
Authors: Coimbra Manuela , Lacerda Araújo Laura Maria , Rosário Filho Nelson Augusto
Published: September 2023

Objective: To evaluate the relationship between the occurrence of contact urticaria in reaction to cow’s milk in infants and the diagnosis of cow’s milk allergy (CMA) established by supervised oral food challenge.
Methods: In this cross-sectional study, we identified 184 children who had undergone 221 oral food challenge (OFC) at a CMA reference center between July 2015 and August 2019. Of these, 23 (12.5%) had a history of contact urticaria to cow’s milk and underwent a total of 30 OFC. Baked cow’s milk OFC were excluded, and 21 children were included in the study. All data from clinical history and allergy tests (serum-specific IgE dosages and skin prick test [SPT] with reconstituted cow’s milk formula) were recorded on standardized forms. The challenge was conducted with reconstituted cow’s milk formula in increasing volumes every 15–20 min.
Results: 24 OFC were performed; 13/24 (54.2%) for diagnostic purpose and 11/24 (45.8%) to evaluate cow’s milk tolerance. Allergy tests were positive in 14 patients (87.5%). Positive oral challenge outcomes were identified in 7/24. One patient had a late flare of atopic dermatitis and five children presented with immediate urticaria (two generalized urticaria and three perioral urticaria). The median papule diameter was 6.5 mm in patients with a positive OFC and 3.75 mm in the negative group (P = 0.02).
Conclusion: The occurrence of contact urticaria might be the only manifestation among infants sensitized to cow’s milk with tolerance to oral ingestion. Reactions due to oral challenge were related to a larger wheal diameter on the SPT.
A Ironia e a Crítica Feminista de The Handmaid’s Tale
Authors: Gonçalves Ana Letícia Barbosa de Faria
Published: September 2023

Resumo: A presente análise crítica de The Handmaid’s Tale, de Margaret Atwood (1996), propõe explorar a ironia como estratégia retórica fértil a uma perspectiva feminista. A partir da identificação dos níveis de leitura incitados pela obra, examinamos como o olhar às investidas irônicas do romance permite a formação de uma comunidade de leitoras. O trabalho crítico de Wayne Booth (1974; 1983) é utilizado como aparato teórico central em direção a uma leitura feminista que, a partir da ironia, acolhe a história da protagonista em harmonia com as intenções implícitas da autora.
Sutilezas do relacionamento afetivo-sexual entre mulheres em Retrato de uma Jovem em Chamas
Authors: Souza Carolina de , Santos Manoel Antônio dos
Published: September 2023

Resumo: Os discursos normativizantes que oprimem as mulheres lésbicas prescrevem como legítima a heterossexualidade como base de funcionamento da organização social. Para reforçar a heteronormatividade, a existência lésbica é mantida invisibilizada ou desqualificada como sexualidade volúvel. O objetivo deste estudo é analisar as sutilezas do relacionamento afetivo entre mulheres como insurgências frente a esse apagamento. Para tanto, parte-se da leitura do filme Retrato de uma Jovem em Chamas, com base nas teorias feministas de gênero. Tendo como método a etnografia de tela, as análises foram amparadas na descrição de diálogos/cenas extraídos/as da narrativa cinematográfica. Inspiradas na arte, as protagonistas criam soluções criativas para desatar os nós das amarras que as impedem de viverem plenamente a relação. A obra celebra a potência subversiva do amor entre mulheres, não apenas pelo vértice do vínculo amoroso, mas também de diferentes alianças e relações de cumplicidade e sororidade possíveis.
Crítica da Educação Financeira na Educação Matemática
Authors: Sachs Línlya , Gereti Laís Cristina Viel , Ferraiol Thiago Fanelli , Elias Henrique Rizek , Souza Luiza Gabriela Razêra de
Published: September 2023

Resumo O presente artigo tem como objetivo tecer uma crítica da educação financeira na Educação Matemática, por meio de uma revisão sistemática da literatura. A partir de uma fundamentação teórica de base marxista, considera-se que realizar uma crítica da educação financeira pressupõe uma compreensão do próprio sistema capitalista e de seus aspectos ideológicos. Assim, foi realizado um levantamento bibliográfico de artigos que tratam do tema educação financeira em todos os volumes disponíveis até o ano de 2021 de 51 periódicos escolhidos. Foram encontrados 229 artigos em 37 periódicos, sendo que a primeira publicação data do ano de 2007. Para as análises, foram utilizadas categorias criadas a posteriori , isto é, a partir da leitura dos textos levantados. Os resultados evidenciam que, por um lado, cinco artigos (2,2%) apresentam críticas ao sistema capitalista, 47 (20,5%) a aspectos do sistema e 174 (76%) não fazem essa crítica e, por outro lado, um artigo (0,4%) apresenta algum tipo de proposição revolucionária, oito (3,5%) proposições reformistas, 74 (32,3%) proposições comportamentais, 106 (46,3%) proposições instrumentais e 66 artigos (28,8%) são não propositivos. O panorama das pesquisas em educação financeira aponta para a necessidade de investigações que abordem o tema pautadas em conhecimentos científicos, em especial, das ciências sociais, como economia e sociologia. A quase ausência de bases teóricas nessas áreas no corpus analisado pode indicar uma fragilidade das pesquisas da Educação Matemática, pois, apesar de se fundamentarem em pressupostos científicos próprios do campo educacional, promovem discursos ideológicos das instituições financeiras, que possuem o objetivo do lucro.
Comparación de Tendencias sobre la Modelización Matemática entre Latinoamérica y el Resto del Mundo: Una Revisión Bibliográfica
Authors: Acuña Fredy Peña , Rojas Armando Solares , Babb Armando Preciado , Rocha Andrea Ortiz
Published: September 2023

Resumen Presentamos una comparación de tendencias sobre la modelización matemática entre Latinoamérica y el resto del mundo a través de un análisis documental de 561 escritos, publicados entre 1980 y mediados de 2021, entre artículos de las principales revistas de investigación a nivel internacional y capítulos de libros. El análisis se centró en las perspectivas de modelización, los contenidos educativos y las poblaciones en las que se enfocan los documentos revisados. Los resultados de este análisis dan cuenta de tendencias globales y permiten identificar características específicas de las publicaciones latinoamericanas que contrastan con las publicaciones en el resto del mundo; sin embargo, este estudio también da cuenta de tendencias locales que no se extienden a toda la región.
Reivindicando la Teoría de las Situaciones Didácticas: un Paradigma de Investigación Vigente en la Didáctica de las Matemáticas
Authors: Torres Julián Humberto Santos
Published: September 2023

Resumen La Teoría de las Situaciones Didácticas, desarrollada por Brousseau en la década del 1970, fue una propuesta innovadora especialmente por su convicción de que el campo naciente, la Didáctica de las Matemáticas, debía apoyarse en metodologías que otorgaran un papel esencial al diseño de situaciones capaces de hacer emerger el saber matemático, a partir de las interacciones de los estudiantes con un medio diseñado y controlado. Esta postura cambiaba, radicalmente, la concepción del aprendizaje en su propuesta: el aprendizaje directo y por imitación no tenía cabida en la teoría. Esta teoría ha impulsado diferentes trabajos teóricos y experimentales en los que se reflexiona sobre sus posturas teóricas. También, ha propiciado discusiones y controversias debido a que otras teorías difieren de sus concepciones sobre el diseño, el control de las variables o la concepción del sujeto en el sistema didáctico. El objetivo de este artículo es, luego de hacer un estudio del arte sobre la teoría, defender la tesis de que la Teoría de Situaciones Didácticas es un paradigma que no solo se mantiene vigente en el campo de la Didáctica de las Matemáticas sino, también, que evoluciona gracias a los aportes de diferentes investigadores del campo. Formulo que es necesario compartir con la comunidad de educadores matemáticos interesados o no en la teoría, las interpretaciones y nuevos desarrollos de los pensadores que siguen desarrollando su trabajo bajo estos principios teóricos.
O Entrelaçar do Desenvolvimento do Pensamento Algébrico dos Alunos e da Constituição Profissional Docente: revelações da narrativa pedagógica de uma professora-pesquisadora
Authors: Moreira Kátia Gabriela , Nacarato Adair Mendes
Published: September 2023

Resumo Este artigo tem como objetivo discutir processos do desenvolvimento do Pensamento Algébrico de alunos do primeiro ano do Ensino Fundamental entrelaçado aos processos de constituição profissional da professora-pesquisadora, que tomou como foco de estudo a pesquisa na/da própria prática e as aprendizagens docente e discentes. A presente discussão faz parte de uma pesquisa de doutorado, de abordagem qualitativa, com apoio financeiro da Capes[1]. O cenário de investigação pertencia à rede municipal de uma cidade do interior de São Paulo, uma sala de aula composta por 26 alunos. As reflexões teóricas pautam-se na perspectiva histórico-cultural, nos estudos sobre Pensamento Algébrico e nas narrativas pedagógicas como dispositivo de autoformação e desenvolvimento profissional. Para a análise, apresenta-se uma narrativa pedagógica sobre uma tarefa que aborda uma sequência com padrão recursivo e objetiva a percepção da regularidade e o desenvolvimento de estratégias de generalização. A escrita e a análise narrativa, no contexto da pesquisa na/da própria prática, revelam indícios da constituição profissional da professora, bem como mostram que os alunos do primeiro ano do Ensino Fundamental, engajados numa cultura social de sala de aula de Matemática pautada na problematização, foram capazes de generalizar o padrão de sequências por meio da linguagem materna.
Atividades na Feira de Matemática: possibilidades para uma práxis educativa
Authors: Zabel Marília , Malheiros Ana Paula dos Santos
Published: September 2023

Resumo Este artigo é resultado de uma investigação que teve como objetivo caracterizar as atividades matemáticas desenvolvidas em sala de aula e apresentadas na Feira Regional de Matemática de Rio do Sul (SC), a fim de fundamentar uma práxis educativa. Considerando a abordagem qualitativa de pesquisa, tivemos como materiais empíricos, os relatos de experiências de quatro trabalhos apresentados na referida Feira e entrevistas realizadas com um dos estudantes expositores de cada um dos trabalhos. A análise desses materiais esteve ancorada no legado de Paulo Freire, principalmente no que se refere às ideias de práxis e de diálogo. Obtivemos, nesse processo, quatro categorias: 1) escolha do tema a ser estudado; 2) matematização; 3) diálogo, colaboração e envolvimento com a comunidade escolar e 4) ação-reflexão-transformação. Ao interpretar as categorias, vislumbramos a possibilidade de uma práxis educativa na qual educandos(as) e educadores(as) fazem uma leitura de mundo inicial, no âmbito da percepção, desenvolvem conhecimentos matemáticos para a compreensão dessa leitura e almejam uma ação transformadora coletiva. Ainda, reforçamos a importância de eventos como a Feira de Matemática para a promoção e divulgação dessas atividades.
Examen colegiado y predictores de éxito en los estudiantes de álgebra lineal
Authors: Aguilar-Salinas Wendolyn Elizabeth , Lara Maximiliano De Las Fuentes
Published: September 2023

Resumen Esta investigación se centra en el análisis del examen colegiado de álgebra lineal de una universidad pública de México en los ciclos escolares 2018-2 y 2019-1 a un total de 1209 estudiantes de primer semestre. Dicha investigación comprende la evaluación del examen y la identificación de predictores de éxito en los estudiantes. El examen colegiado está alineado al currículo, es criterial y de opción múltiple. El análisis del examen se compone del cálculo de índices de dificultad, índices de discriminación y coeficientes de correlación, así como de la actividad cognitiva, clasificación del contenido, registro inicial y final de cada reactivo. Los resultados permiten observar que el examen es una prueba confiable y con poder de discriminación satisfactorio, y que entre los reactivos predictores del éxito de los estudiantes se encuentra la resolución de operaciones con números complejos en su forma rectangular, el producto de matrices, la regla de Cramer y el espacio generado por vectores.
Os desafios da Área de Ensino: “é caminhando que se faz o caminho”
Authors: Cyrino Márcia Cristina de Costa Trindade , Rizzatti Ivanise Maria , Rôças Giselle
Published: September 2023

Resumo A pós-graduação brasileira tem sido palco de intensos debates e transformações. Nos últimos anos, enfrentou obstáculos, como a desvalorização da ciência e da educação; a perda de profissionais formados para instituições estrangeiras; a diminuição da procura por programas de pós-graduação; o baixo valor das bolsas de estudo; a instabilidade no MEC e na gestão da CAPES. Diante da complexidade do sistema, surgem desafios que exigem da comunidade acadêmica capacidade de crítica e busca de soluções inteligentes e estratégicas. Neste texto, são apresentados temas inerentes à área de Ensino, considerando sua trajetória, epistemologia, campos de ação e configuração, bem como alguns desafios a serem enfrentados pela área, como as assimetrias locais e regionais; o estabelecimento de critérios para a construção de uma avaliação multidimensional; o acesso e a aderência de discentes e docentes; a carência de políticas inclusivas e acolhedoras em relação à diversidade; a ampliação de diálogo com a comunidade acadêmica; a busca por uma compreensão do que seja inovação e transferência de conhecimento na área; aproximações estratégicas para participação da área nas decisões que afetam a educação no país. Para lidar com tais desafios é preciso envolvimento, capacidade crítica e criativa.
Mensagens telefônicas frente às medidas preventivas contra COVID-19
Authors: Souza Neto Vinicius Lino de , Lopes Camila Takao , Barros Alba Lucia Bottura Leite de , Taminato Mônica , Santos Vinícius Batista , Lopes Juliana de Lima
Published: September 2023

RESUMO Objetivo: Analisar as evidências de validade de conteúdo de mensagens telefônicas frente as medidas preventivas contra a COVID-19. Método: Estudo metodológico, em que as mensagens contendo texto e imagem foram desenvolvidas por meio de uma revisão narrativa de literatura e que tiveram seu conteúdo avaliado por oito juízes em relação a clareza, pertinência prática, relevância teórica e vocabulário. Calculou-se o índice de validade de conteúdo (IVC), e considerou-se com adequadas evidências de validade, as mensagens que alcançaram índices acima de 90%. Resultados: Foram desenvolvidas 18 mensagens de texto/imagens contendo informações sobre a COVID-19, higienização das mãos, uso e manuseio das máscaras e a importância do distanciamento social. Após a segunda rodada de avaliação obteve-se um índice de validade de conteúdo acima de 90% em todos os indicadores avaliados. Conclusão: As mensagens telefônicas foram desenvolvidas e apresentaram adequadas evidências de validade de conteúdo.
Apoio matricial para agentes comunitários de saúde sobre os marcos do desenvolvimento auditivo e de linguagem na primeira infância
Authors: Silva Lidiane Assis da , Silva Vanessa de Lima
Published: September 2023

RESUMO Objetivo analisar o conhecimento dos agentes comunitários de saúde (ACS) sobre os marcos do desenvolvimento auditivo e de linguagem na primeira infância, no contexto da visita domiciliar, antes e após oficina de apoio matricial. Método Foi desenvolvida uma pesquisa-ação, com abordagem quantitativa e qualitativa. Resultados Contribuição significativa para a aprendizagem das ACS enriquecendo a prática da visita domiciliar. Conclusão O apoio matricial é uma importante ferramenta para a atuação qualificada das ACS no tocante às orientações sobre os marcos auditivos e de linguagem na primeira infância.
Changes in the communicative skills of young people as a result of a communication training
Authors: Torres Maria Lucia Graziano Magalhães , Sampaio André Luiz Lopes , Caracas Hugo Cesar Pinto Marques
Published: September 2023

ABSTRACT Purpose To analyze the effect of communication training developed for adolescents on the youth’s communication skills. Methods Forty-one young people participated in the study and were divided into two groups. Group I received intervention - communication training for five weeks; Group II - were guided on the importance of voice for communication. Participants had their communication skills assessed before/after interventions through a self-administered questionnaire, answered by the participant and parents. Both groups had oral presentations recorded on video, which were analyzed by speech therapists through the evaluation of the communication profile, listing the aspects that should be observed as a point of strength/opportunity for improvement. Association between qualitative variables was assessed using Fischer’s exact test, Pearson’s chi-square test, McNemar’s test, and McNemar-Bowker’s test. To compare groups, paired t-test and t-test for independent samples, p level <0.05, were used. Results The analysis of questionnaires showed improvement in GI in two of the four skills assessed and no difference for GII. The video evaluations showed a significant difference between the groups in terms of eye contact and speech velocity. Conclusion This study points out that the communication training method applied to young people might improve communicative skills, providing some insights into their communication strengths and potential areas for development.
Aspectos da atuação do terapeuta ocupacional no contexto hospitalar no primeiro ano da pandemia de COVID-19
Authors: Joaquim Regina Helena Vitale Torkomian , Souza Lucas Ramon Santos de , Sousa Danielle Ferreira de , Beltrame Vitória Hoerbe , Buin Luciana , Moraes Anaelena Bragança de
Published: September 2023

Resumo Introdução A doença COVID-19 ocasionou uma pandemia, gerando sobrecarga nos serviços de saúde, principalmente nas instituições hospitalares, devido à necessidade de internação dos pacientes infectados. Dentre os profissionais da saúde, o terapeuta ocupacional tem contribuído para o enfrentamento da doença. Objetivo Verificar a atuação dos terapeutas ocupacionais em contextos hospitalares no primeiro ano da pandemia pela COVID-19. Método Trata-se de um estudo transversal, exploratório, descritivo e de abordagem quantitativa. A pesquisa foi desenvolvida utilizando-se o Google Forms®, com coleta dos dados por meio de questionário com perguntas abertas e fechadas, tendo como participantes terapeutas ocupacionais atuantes na assistência em contextos hospitalares. Os dados foram descritos e analisados estatisticamente por meio do software Statistica 9.1 e do teste Exato de Fisher. Resultados Participaram 36 terapeutas ocupacionais, destes, 23 atenderam pacientes com COVID-19 (63,9%). Dos participantes, 75% responderam que modificaram sua intervenção com o início da pandemia e 91,7% consideraram sua atuação fundamental nesse período. O percentual de terapeutas que considera a sua atuação como terapeuta ocupacional fundamental durante a pandemia no grupo que trabalhou com pacientes com COVID-19 (p=0,040) é significativamente maior em relação ao grupo que não trabalhou com pacientes com COVID-19 (76,9%). Na atenção ao paciente com COVID-19, a maioria dos terapeutas ocupacionais respondeu que sua atuação era específica do escopo da profissão (86,9%) e importante no combate à doença (60,8%). Conclusão Os resultados trazem dados esclarecedores sobre as intervenções de terapeutas ocupacionais, levando a discussões crítico-reflexivas sobre a necessidade de se apropriar de uma nova prática em contexto hospitalar.
La dimensión espiritual en el anciano desde el modelo de la gerotrascendencia y su abordaje desde la terapia ocupacional: revisión bibliográfica
Authors: Cintado Fernández Purificación , Lázaro Pulido Manuel
Published: September 2023

Resumen Introducción El campo de estudio del envejecimiento conoce un marco teórico conocido como gerotrascendencia. La gerotrascendencia entiende la vejez como la etapa final de una progresión natural que lleva a alcanzar la madurez y la sabiduría. La ancianidad es, así, una etapa de introspección entendida como espiritualidad que se explica también en un contexto religioso. Objetivo Comprobar desde la literatura científica la implementación de la gerotrascendencia y sus aspectos fundamentales en el marco de la terapia ocupacional. Metodología Estudio bibliográfico ejecutado por un estudio previo de Google Trends para conocer el tráfico de datos. Su usan bases de datos especializadas en ciencias de la salud (Pubmed, Medline, EMBASE, CINAHL complete, LILACS, Medes, CUIDENplus, Cuidatge, Cochrane Library, Trip medical database, Epistemonikos e IBECS), en el área de psicología (Psicodoc, PsycArticles, PsycBooks, PsycInfo y Psychology and Behavioral Sciences Collection), y multidisciplinares (Google Scholar, Web of Science y Scopus) a partir de una exploración booleana/frase (operadores: AND, OR, NOT). Se utilizan los tesauros especializados (MeSH, DeCS y HONselect) usando palabras clave en español e inglés: gerotrascendencia, enfermería, terapia ocupacional. El uso de bases de datos y un sistema de cribado basado en objetivos da como resultado el estudio especifico de seis artículos. Resultados La gerotrascendencia conoce una bibliografía consolidada en inglés, pero que es casi inexistente en español. De entre los estudios en español existen estudios sólidos con resultados que plantean una alternativa a los modelos materialistas que plantean un enfoque que se reducen al paradigma biomédico. Estos estudios plantean una ética de las necesidades y un enfoque centrado en la atención al usuario, donde la espiritualidad (religión interna) y su vivencia religiosa externa tienen una gran importancia. Conclusión La terapia ocupacional no puede olvidar los modelos teóricos centrados en la persona, de modo que puedan salir del corsé biomédico, al que pertenecen, pero al que no se reducen. Parece necesario realizar más abordajes teóricos y estudios cuantitativos y cualitativos que revelen la operatividad de la implementación de modelos que entiendan la fenomenología del envejecimiento de forma holística, como es el caso de la gerotrascendencia.
Parasitism by Amblyomma rotundatum on Teiidae lizards in the eastern part of the state of Acre, Brazil
Authors: Tojal Simone Delgado , Costa Ivaneide Nunes da , Aguirre André de Abreu Rangel , Martins Thiago Fernandes , Labruna Marcelo Bahia , Meneguetti Dionatas Ulises de Oliveira , Bernarde Paulo Sérgio , Cruz Karoline Silva da , Lima Jônatas Machado , Prolo Júnior Sergio Luiz , Camargo Luís Marcelo de Aranha
Published: September 2023

Abstract The aim of the present study was to report on the occurrence of parasitism by Amblyomma rotundatum ticks on two species of Teiidae lizards and test the presence of rickettsiae in the collected ticks, in the western Brazilian Amazon region. Ticks were collected in July 2019, from a fragment of terra firme forest in the municipality of Senador Guiomard, Acre, Brazil. Two lizards that were infested by immature stages of ticks were caught using mist net and Tomahawk traps. Ectoparasites were collected manually, and the lizard specimens were identified and released at the same location where they had been caught. Three nymphs and 49 larvae were collected from Ameiva ameiva, while 25 nymphs and nine larvae were collected from Tupinambis cuzcoensis, which are both in the family Teiidae. The ticks were identified morphologically as belonging to the genus Amblyomma. Nymphs were identified at species level through molecular analysis, resulting in the tick species Amblyomma rotundatum. This is the first record of parasitism by the tick A. rotundatum on T. cuzcoensis lizard, and the first report of an association between A. rotundatum and the lizard species A. ameiva and T. cuzcoensis in Acre, in the western part of the Amazon region.
Molecular Expression and Prognostic Implications of Krüppel-Like Factor 3 (KLF3) in Clear Cell Renal Cell Carcinoma
Authors: Wan Bin , Zhang Wensheng , Deng Xinxi , Lu Yigang , Zhang Zhuo , Yang Yang
Published: September 2023

A major subtype of renal cancer is clear cell renal cell carcinoma (ccRCC). Krüppel-like factor 3 (KLF3) dysfunction is also revealed leading to poor prognosis in multiple cancer types. However, dysregulation and molecular dynamics of KLF3 underlying ccRCC progression still remains elusive. Here KLF3 gene and protein expressions in ccRCC were explored using data cohorts from The Cancer Genome Atlas (TCGA), Human Protein Atlas (HPA), Clinical Proteomic Tumor Analysis Consortium (CPTAC) and verified them in our patient cohort. Correlations of KLF3 expression with clinicopathological features, epigenetic modification, and immune microenvironment characteristics were further investigated. KLF3 was significantly down-regulated expressed in ccRCC tissues compared to adjacent normal controls. Adverse pathological parameters and poor prognosis were associated with lower expression of KLF3. Mechanically, KLF3 regulation was mainly attributed to CpG island methylation. KLF3-high expression subgroup was significantly enriched in cell signaling pathways most associated with EMT markers, angiogenesis, inflammatory response, apoptosis, TGF-β, degradation of ECM, G2M checkpoint, and PI3K-AKT-mTOR. Based on GDSC database, KLF3 upregulation was identified to be associated with higher sensitivities towards PI3K-Akt-mTOR pathway inhibitors such as PI-103, PIK-93, and OSI-027. In addition, patients with down-regulated KLF3 expressions were found more sensitive towards Trametinib, Cetuximab, and Erlotinib. Collectively, our findings suggest that KLF3 may act as a suitable biomarker for prognosis prediction, tumor microenvironment (TME) phenotype identification, thereby helping ccRCC patients to make better therapeutic decisions.
Bromodomain Proteins Epigenetically Regulate the Mitotically Associated lncRNA MANCR in Triple Negative Breast Cancer Cells
Authors: Tracy Kirsten M. , Prior Shannon , Trowbridge Willem T. , Boyd Joseph R. , Ghule Prachi N. , Frietze Seth , Stein Janet L. , Stein Gary S. , Lian Jane B.
Published: September 2023

Long non-coding RNA (lncRNA)-mediated control of gene expression contributes to regulation of biological processes that include proliferation and phenotype, as well as compromised expression of genes that are functionally linked to cancer initiation and tumor progression. lncRNAs have emerged as novel targets and biomarkers in breast cancer. We have shown that mitotically associated lncRNA MANCR is expressed in triple-negative breast cancer (TNBC) cells and that it serves a critical role in promoting genome stability and survival in aggressive breast cancer cells. Using an siRNA strategy, we selectively depleted BRD2, BRD3, and BRD4, singly and in combination, to establish which bromodomain proteins regulate MANCR expression in TNBC cells. Our findings were confirmed by using in situ hybridization combined with immunofluorescence analysis that revealed BRD4, either alone or with BRD2 and BRD3, can support MANCR regulation of TNBC cells. Here we provide evidence for MANCR-responsive epigenetic control of super enhancers by histone modifications that are required for gene transcription to support cell survival and expression of the epithelial tumor phenotype in triple negative breast cancer cells.
An Eye Tracking Based Framework for Safety Improvement of Offshore Operations
Authors: Raza Muhammad , Kiran Raj , Ghazal Saima , Jeon Jiwon , Salehi Saeed , Kang Ziho , Cokely Edward
Published: September 2023

Offshore drilling operations consist of complex and high-risk processes. Lack of situational awareness in drilling operations has become an important human factor issue that causes safety accidents. Prolonged work shifts and fatigue are some of the crucial issues that impact performance. Eye tracking technology can be used to distinguish the degree of awareness or alertness of participants that might be related to fatigue or onsite distractions. Oculomotor activity can be used to obtain visual cues that can quantify the drilling operators’ situational awareness that might enable us to develop warning alarms to alert the driller. Such systems can help reduce accidents and save non-productive time. In this paper, we used eye tracking techniques to differentiate the situational awareness between a representative expert and a group of novices using a scenario-based Virtual Reality Drilling Simulator. Significant visual oculomotor activity differences were identified between the expert and the novices that indicate an eye-tracking based system can detect the distraction and alertness exhibited by the workers. The findings might be used for the development of a framework for implementing a real-time eye tracking technology in various drilling operations at drilling rigs and Real Time Operation Centers to improve process safety.
Fundamentally new approaches to solving thermophysical problems in the field of nanoelectronics
Authors: Khvesyuk V. I. , Barinov A. A. , Liu B. , Qiao W.
Published: September 2023

Currently, there is a rapid development of thermophysics of solids associated with the need of creating models with a high degree of predictive reliability. This paper presents new approaches to solving relevant issues related to the study of heat transfer in semiconductors and dielectrics, mainly concerning nano-structures. The first of the considered tasks is the creation of a statistical model of the processes of interaction of heat carriers – phonons – with rough surfaces of solids. For the first time authors proposed a method based on the statistics of the slopes of the profile of a random surface. The calculation results are the mean free paths of phonon between the opposite boundaries of the sample, which are necessary for calculating the effective thermal conductivity in ballistic and diffusion-ballistic regime of heat transfer, depending on the roughness parameters. The second task is to develop methods for calculating the processes of heat transfer through the contact surfaces of solids. We were able to show that, taking into account the phonon dispersion and the corresponding restrictions on the frequency values, the modified acoustic mismatch model for calculating Kapitsa resistances can be extended to temperatures above 300 K. Previously, the limit of applicability of this method was considered to be a temperature of 30 K. Moreover, the proposed method is also generalized to the case of rough interfaces. The third task is a new approach to determining the thermal conductivity of solids. The authors have developed a method of direct Monte Carlo simulation of phonon kinetics with strict consideration of their interaction due to the direct use of the laws of conservation of energy and quasi-momentum. The calculations of the thermal conductivity coefficient for pure silicon in the temperature range from 100 to 300 K showed good agreement with the experiment and ab initio calculations of other authors, and also allowed us to consider in detail the kinetics of phonons.
Постдемократия
Authors: Крауч Колин
Published: August 2023

В своей нашумевшей в западной интеллектуальной и научной среде книге профессор социологии Уорикского университета (Великобритания) Колин Крауч утверждает, что упадок общественных классов, которые сделали возможной массовую политику, и распространение глобального капитализма привели к возникновению замкнутого политического класса, больше заинтересованного в создании связей с влиятельными бизнес-группами, чем в проведении политических программ, отвечающих интересам простых граждан. Он показывает, что в ряде отношений политика начала XXI века возвращает нас к политике XIX столетия, которая определялась игрой, разыгрываемой между элитами. Тем не менее, по утверждению Крауча, опыт XX века по-прежнему остается значимым и сохраняет возможности для возрождения политики. Книга предназначена политологам, историкам, философам и социологам.
KAPP-Sen TMC: Tissue Section Preparation for 10x Genomics Visium CytAssist v1
Authors: Alcoforado Diniz Juliana
Published: September 2023

Sectioning was performed by the JAX Histology core in BH, ME. All experiments preceding this technique were performed at 4°C and RNase-free, as described in this protocol. Tissue sections are further used for Visium Spatial Gene Expression assay performed by the Single Cell Biology Core at The Jackson Laboratory for Genomic Medicine.
DNA extraction from recently fertilised Atlantic salmon embryos for use in microsatellite validation of triploidy v1
Authors: Howard Callum
Published: September 2023

The current methods used for producing triploid Atlantic salmon are generally reliable but not infallible, and each batch of triploids must be validated to ensure consumer trust and licensing compliance. Microsatellites have recently been shown to offer a cheaper and more convenient alternative to traditional flow cytometry for triploidy validation in a commercial setting. However, incubating eggs to at least the eyed stage for microsatellite validation poses challenges, such as reduced quality and performance of triploids produced from later eggs in the stripping season. To address these issues, we propose another option: extracting DNA from recently fertilised eggs for use in conjunction with microsatellite validation. To achieve this, we have developed an optimized protocol for HotSHOT extraction that can rapidly and cheaply extract DNA from Atlantic salmon embryos, which can then be used for triploidy validation through microsatellites. Our approach offers a simpler and more cost-effective way to validate triploidy, without the need for skilled dissection or expensive kits.