bluuebunny/crossref_metadata_2025 huggingface dataset:
An Ayurvedic Intervention for Subconjunctival Hemorrhage (SCH) Resulting in Early Alleviation of Disease — A Case Report
Authors: Madhukar Madhav , Jagtap Pallavi , Shiralkar Mayur
Published: November 2023

Introduction: Subconjunctival Hemorrhage (SCH) is a common condition of the eye that has distinct characteristic features, such as the acute appearance of a sharply circumscribed redness of bleeding underneath the conjunctiva in the absence of discharge, and inflammation in the affected areas, which is painless. We are now disclosing a case of subconjunctival bleeding caused by local minor trauma and eye rubbing. This case was unique as the healing time, which was usually 1 to 2 weeks, was reduced to 5 days after the intervention of ayurvedic formulations. Case Presentation: A 60-year-old man who had redness in his left eye for one day came to the OPD setting. Redness and inflammation were present, as shown by direct clinical questioning. Later, a clinical examination confirmed both symptoms. A subconjunctival hemorrhage was confirmed by the way the eye appeared. Conclusion: Subconjunctival hemorrhage may exhibit signs of other conditions that pose a risk to the eyes. To make a distinction between those causes and localized subconjunctival hemorrhage, a clinical assessment was necessary.
Emblica officinalis Gaertn. (Amalaki): A Natural Herbal Remedy to Enhance Cardiorespiratory Fitness in Ayurveda - An In Silico Molecular Docking Approach
Authors: Chandran Amal S. , Patil Ashok , Kumar Sanjiv , Muralidharan Krishika , Kaimal Sreeja V.
Published: November 2023

Background: Cardiorespiratory fitness is the capacity of the circulatory and respiratory systems to transport oxygen to the skeletal muscle mitochondria for energy production during physical activity. Cardiorespiratory fitness has been recognized as a vital health biomarker and is very crucial for sports persons. Physical activities, aerobic exercise, yoga, meditation, nutritional supplements, and ergogenic aids are the ways to enhance cardiorespiratory fitness. Emblica officinalis Gaertn. is one of the widely used drugs in Ayurveda traditional medicine to enhance Cardiorespiratory Fitness (CRF). However, there is a dearth of clear information regarding how Emblica officinalis can improve CRF. Objective: The current in silico molecular docking study was planned to identify the phytochemicals, and targets of endurance and predict the probable mode of action of the drug and thereby substantiate the ability of Emblica officinalis as a natural and ethical way of enhancing cardiorespiratory fitness. Methods: The phytochemicals and targets are collected from reliable sources, and the effectiveness of these gene targets was validated using network pharmacology ligand-target interaction methods. The Protein Data Bank and PubChem were used to find the ligands and targets, and PyRx was used to do docking. Conclusion: Emblica officinalis is found to have a positive influence on the 12 metabolic pathways that act in enhancing the cardiorespiratory endurance in the human being. PRKCA was analyzed and concluded as the highly modulated gene target with the lowest binding energy. Thus, Emblica officinalis was found to have an action in enhancing cardio-respiratory endurance.
SMART HOME IOT: UMA ANÁLISE ACERCA DA REDUÇÃO DO CONSUMO DE ENERGIA ELÉTRICA RESIDÊNCIAL COM DISPOSITIVOS SMART ACESSÍVEIS
Authors: Casagrande Cristiano Gomes , Rodrigues Ana Carolina Caldas , Guimarães Tuanny Cristinny da Cunha
Published: November 2023

Este artigo faz uma análise a respeito de como o avanço e disseminação da internet culminou em novos padrões de comportamento. Percebe-se que o desenvolvimento de novas tecnologias possibilita o surgimento de produtos com certo grau de inteligência que podem otimizar as tarefas diárias dos indivíduos. Por conseguinte, o novo conceito de smart home apresenta a possibilidade do uso mais eficiente de aparelhos domésticos para economia de energia, por meio de estratégias que colaboram para a eficiência energética sem grandes compromissos financeiros. O objetivo deste artigo é apresentar alguns dispositivos com foco nas smart home que possam ser adquiridos de forma acessível financeiramente, ou seja, com baixo custo e que não exijam um sistema de instalação complexo, como demais automações que elevam o custo final do produto. O trabalho partiu da pesquisa bibliográfica e documental com base nas seguintes temáticas: internet das coisas, smart home, eficiência energética e sistemas e dispositivos. Além disso, foi realizada uma busca mercadológica por tecnologias e produtos inteligentes comercializados no Brasil, com baixo custo e de fácil instalação. O principal resultado desta pesquisa expõe alguns dispositivos que podem auxiliar na redução do consumo de energia e que se apresentam acessíveis no mercado com valores variáveis de acordo com marca e modelo.  Posto isso, nota-se a viabilidade de adotar novas estratégias nas residências brasileiras, a partir dos dispositivos mencionados para corroborar com políticas governamentais que incentivem a eficiência energética, com o intuito de fortalecer um dos objetivos do desenvolvimento sustentável da ONU, produção e consumo responsáveis.
CAMINHANDO PELO CENTRO HISTÓRICO DE CÁCERES-MT: PERCEPÇÕES DE UM DEVANEIO URBANO
Authors: Mininel Willian Jonas , Busnardo Filho Antonio , Soukef Júnior Antonio
Published: November 2023

A cidade de Cáceres está localizada na mesorregião Centro Sul mato-grossense, Microrregião do Alto Pantanal. Tem uma importância histórica tanto para o estado de Mato Grosso quanto para o Brasil, pois seu início de urbanização data de 1778, tornando-se peça-chave na colonização do extremo Oeste brasileiro e da capitânia de Mato Grosso e Cuiabá. O presente trabalho busca analisar algumas obras encontradas no centro histórico da atual cidade de Cáceres. A caminhada não teve um roteiro preciso, teve apenas a curiosidade como guia. Durante esse trajeto algumas fotos foram registradas e a partir disso foi comparada a situação atual das casas tombadas com o que é descrito na Carta de Veneza, na Declaração de Amsterdã e na Carta de Washington. Ao fazer esta comparação, percebe-se que as casas tombadas na cidade não seguem os princípios que norteiam os documentos. Faz-se necessário um estudo mais aprofundado para compreender a relação que o município mantém com o centro histórico e quais as medidas de preservação e incentivos educacionais que deveriam ser elencados fim de reverter o abandono e o descaso com o patrimônio local.
CONSIDERAÇÕES A RESPEITO DO ESTATUTO LEGAL NO CASO DA COMUNIDADE DA RUA MONSENHOR RUBENS MESQUITA, SALVADOR - BA
Authors: Bahia Adriana Teixeira , Luz Vera Santana
Published: November 2023

Este artigo é desdobramento da pesquisa de doutorado em desenvolvimento. No texto que segue, retratamos o objeto de estudo, a Comunidade da Rua Monsenhor Rubens Mesquita, Salvador – BA, a partir do estatuto legal, tendo também como foco a discussão do direito à moradia e à cidade. A Rua estudo de caso vive, desde 2018, um processo de reintegração de posse. Os moradores que ali habitam estão sendo expulsos em prol da construção de um Shopping Center. De modo a alcançarmos os objetivos propostos, investigamos a legislação urbanística no âmbito federal e municipal, especialmente as que incidem sobre o território, como o Plano Diretor de Desenvolvimento Urbano de Salvador de 2016, que classifica esse espaço como uma Zona de Interesse Social (ZEIS) e a Lei de Ordenamento do Uso e da Ocupação do Solo.  A determinação do estudo de caso como ZEIS nos leva à discussão da capacidade dos instrumentos legais em serem efetivos no que tange ao espaço urbano, em suas determinações. Como processo metodológico, de caráter indutivo, levanta-se, a partir do estudo de caso e referências documentais, uma indagação a respeito da dicotomia recorrente entre o estatuto legal e o estatuto da realidade, como contribuição para a compreensão das contradições que envolvem as decisões que pautam o futuro das nossas cidades.
MOBILIDADE URBANA E POLÍTICAS PÚBLICAS PARA CICLABILIDADE
Authors: Ribeiro Nathalia dos Santos , Gallo Douglas
Published: November 2023

A mobilidade ativa é uma estratégia fundamental para a garantia de cidades mais saudáveis, sustentáveis, seguras e humanas. As políticas públicas são fundamentais para a consolidação de um modelo de cidade que privilegia a escala e a dimensão humanas, possibilitando a configuração de espaços que privilegiem o deslocamento a pé e por bicicleta, e criando cidades mais ativas. O objetivo do artigo é relacionar a mobilidade ativa com a infraestrutura do planejamento urbano da cidade de São Paulo, discutindo como o planejamento pode considerar a saúde da população, contribuindo para uma cidade com mais qualidade de vida. Além disso, procura-se analisar como se deu o desenvolvimento de políticas públicas relacionadas ao ciclismo urbano na cidade, visto que elas contribuem para incentivar o uso do transporte ativo. Embora tenham ocorridos avanços com a criação de uma legislação e planejamento focados na ciclabilidade, a cidade de São Paulo ainda possui grandes desafios e potencial para expansão da malha cicloviária, particularmente nos territórios mais periféricos e desiguais.
A SEGREGAÇÃO SOCIOTERRITORIAL: O BAIRRO CARAPINA EM GOVERNADOR VALADARES/MG NA CONTEMPORANEIDADE
Authors: Pereira Iaminne Rodrigues , Cunha Claudia dos Reis e , Laurentiz Luiz Carlos de
Published: November 2023

O presente trabalho tem como foco desvelar o Bairro Carapina, localizado na cidade de Governador Valadares/MG, e como impera a segregação neste microterritório, cindido em duas áreas distintas: uma mais adequadamente urbanizada e outra bastante precária, conhecida popularmente como Buracão. O objetivo do trabalho é investigar sua condição de área periférica dentro da cidade de Governador Valadares. Como metodologia utilizou-se a pesquisa de campo, experiências erráticas e deambulações, além da análise survey. O presente artigo surge de uma pesquisa de mestrado em andamento, que busca dar voz à comunidade do Bairro Carapina, já que é um território que historicamente foi invisibilizado. Assim, o estudo reveste-se de uma relevância social ao aproximar a academia da sociedade. Ademais, no âmbito político, a pesquisa apresenta convergência da temática com a meta da Agenda 2030, com o objetivo de número 11, que busca tornar as cidades mais sustentáveis, seguras e resilientes. Como resultado preliminar, percebe-se que o Bairro ainda vivencia uma realidade de segregação especialmente sociocultural, tendo em vista que sua localização no tecido urbano não o caracteriza como propriamente periférico. Assim, o estudo também busca lançar luzes sobre estudos urbanísticos que tradicionalmente apresentam segregação e periferia praticamente como sinônimos, apontando que o fenômeno da segregação pode ter outras formas de manifestação em nossos espaços urbanos tão desiguais.
Device for Determining Variations in Stem Thickness of Trees
Authors: Chimarro J. , Freire F.
Published: November 2023

In precision agriculture, obtaining accurate information in real-time is essential when making relevant decisions; for example, to determine the hydric stress of plants, continuous monitoring of different plant variables such as stem thickness is required, since this is a very relevant indicator to define the water need. For this purpose, a low-cost prototype was developed to constantly monitor the fluctuations of the diameter of the trunk of a tree. The device has been designed so that it can acquire information autonomously with the help of a control software,. The sensitivity of the device allows measuring variations of up to 8 mm, which is considered optimal for this type of need. During the development of the prototype, the mechanical and electronic structure was designed using simulation software, considering the technical characteristics and functional requirements of the sensor, a control system and power supply. The prototype was built using a 3D printer, the mathematical model used in the control system was validated in a controlled environment presenting a percentage error of 2%, which is considered acceptable, prior to the implementation of the prototype in the field.
Keywords: agriculture, water stress, log diameter, 3D model.
Resumen
En la agricultura de precisión la obtención de información precisa y en tiempo real es fundamental al momento de tomar decisiones relevantes; por ejemplo, para determinar el estrés hídrico de las plantas se requiere de un monitoreo continuo de diferentes variables de la planta como el grosor del tallo puesto que este es un indicador de mucha relevancia para poder definir la necesidad hídrica. Con esta finalidad se desarrolló un prototipo de bajo costo para monitorear constantemente las fluctuaciones del diámetro del tronco de un árbol, el dispositivo ha sido diseñado de manera que pueda adquirir información de forma autónoma apoyado por un software de control, la sensibilidad del dispositivo permite medir variaciones hasta de 8 mm, lo cual se considera óptimo para este tipo de necesidad. Durante el desarrollo del prototipo se diseñó la estructura mecánica y electrónica utilizando software de simulación, tomando en cuenta las características técnicas y requerimientos funcionales del sensor, del sistema de control y alimentación. El prototipo se construyó utilizando una impresora 3D, el modelo matemático utilizado en el sistema de control fue validados en un entorno controlado presentando un error porcentual del 2 %, lo cual se considera aceptable, previo a la implementación del prototipo en campo.
Palabras Clave: Agricultura, Estrés hídrico, Diámetro de troco, Modelo 3D.
Structural Modeling of Straw Bale Loadbearing Wall
Authors: Arroba L. P. Viera , Coronel G. D. Pacheco , Amaguaña J. M. Vásquez
Published: November 2023

In Ecuador, there are qualitative and quantitative housing deficits that must be covered with materials that produce seismic-resistant, energy-efficient buildings that do not require a large amount of energy to be produced. Several studies indicate that the answer lies in straw bale structures. However, for these to be considered by designers, aids are needed to facilitate their structural modeling in specialized computer programs. Through literature reviews, the present research proposes a model that adapts the specific structural considerations of straw bale buildings to the tools available in a design program.
Keywords: structure, bales, straw, model, program, design.
Resumen
En el Ecuador existe un déficit cualitativo y cuantitativo de viviendas que debe ser cubierto con materiales que produzcan edificaciones sismo resistentes, energéticamente eficientes y a la vez que no requieran gran cantidad de energía para ser producidos. Varios estudios señalan que la respuesta está en las estructuras elaboradas con fardos de paja. Sin embargo, para que éstas sean consideradas por los diseñadores son necesarias ayudas para facilitar su modelamiento estructural en programas informáticos especializados. La presente investigación, a través de revisiones bibliográficas, propone un modelo que adapta las consideraciones estructurales específicas de las construcciones con fardos de paja a las herramientas disponibles en un programa de diseño.
Palabras Clave: estructura, fardos, paja, modelo, programa, diseño
Factors that Affect the Business Performance of Commercial Mipymes in the Tarqui Parish of Guayaquil
Authors: Paola Quimi Franco Wendy , Ivonne Quimi Franco Dennise , Javier Flores Villacrés Emilio , Elías Merizalde Andrade Christian
Published: November 2023

Abstract This study aims to analyze the factors that affect the business performance of commercial MSMEs in the Tarqui parish of Guayaquil to establish useful strategies in the market. In the study, surveys were applied that indicated which factors can help improve the development and growth of MSMEs, which correspond to those that involve the adoption of new technologies, innovation, diversification, and training. Based on the above data, it was proposed to measure their performance through a descriptive study that interprets the perceptions of the owners. The survey was conducted on 50 owners or administrators who answered the questions, which reflected a very low performance of these Mipymes that are concerning, and should be addressed. Therefore, it was decided to propose strategies for Mipymes to position themselves in the market where different points are detailed, such as the training of entrepreneurs, having more facilities to obtain leverage, product diversification, and customer loyalty.
Keywords: business performance, strategies, MSMEs, entrepreneurs.
Resumen
La esencia de este estudio es analizar los factores que inciden en el desempeño empresarial de las Mipymes comerciales en la parroquia Tarqui de Guayaquil, con el fin de establecer estrategias que sean útiles para mejorar su permanencia en el mercado. En el estudio se aplicaron encuestas que nos indicaron que factores pueden ayudar a mejorar el desarrollo y crecimiento de las Mipymes los cuales corresponden a aquellos que involucran la adopción de nuevas tecnologías, la innovación, diversificación y capacitación. En base a lo expuesto se plantea medir su desempeño a través de un estudio descriptivo que interprete las percepciones de los propietarios, la encuesta se aplicó a 50 dueños o administradores que respondieron a las preguntas, que reflejaron un desempeño muy bajo de estas Mipymes lo cual es un peligro muy preocupante, que debería de ser atendido. Por lo tanto, se decidió proponer estrategias para que las Mipymes logren posicionarse en el mercado donde se detallan diferentes puntos tales como la formación de emprendedores, tener más facilidades para la obtención de un apalancamiento, diversificación de productos, y fidelización de clientes.
Palabras Clave: Desempeño empresarial, estrategias, Mipymes, Emprendedores.
Książę Józef Poniatowski w twórczości Kazimierza Bartoszewicza
Authors: Florczak Ilona
Published: November 2023

Kazimierz Bartoszewicz (1852–1930), writer and historian, living in Krakow, Galicia, in his journalistic works dealt with the popularization of the history of the Polish nation. He was highly regarded by readers of participated Poland journalist and social activist. Among his articles were texts on the life and work of Joseph Poniatowski. Most works on nephew of Stanislaus Augustus wrote in 1913, that is, on the centenary of the death of Prince at the Battle of Nations at Leipzig, including the same in the nationwide celebration of this event. Under the influence of nineteenthcentury legend surrounding the figure of Prince Joseph, he was trying newly built national hero myth of Joseph Poniatowski. Like other writers and historians, especially in Galicia, in Bartoszewicz’ works, prince was not only an excellent leader and commander, full of youthful charm favorite ladies, but first and foremost a defender of honor of the Polish nation, faithful to the idea and the nation. These features, highlighted many times in press releases, literature, and finally backed up prior to the work of historians (especially in the biography of the Duke, author Simon Askenazy) made of Joseph Poniatowski figure worthy of inclusion in the pantheon of national heroes, particularly during the period when the Polish people again began to loudly talk about independence, and when he began to develop in Galicia Polish paramilitary movement, the members of the Prince Joseph was the best model.
Demography of Cholanaickan, the Cave-men of Kerala – India
Authors: Bhanu B.  A. , Saheb S. Yaseen
Published: November 2023

Cholanaickans, a tribe of hunters-gatherers from Kerala State in India were investigated from the demographic aspect. On the basis of data from many years the dynamics of changes of the group structure was presented. Special attention was devoted to the mating system and reproduction.
A new perspectives on breastfeeding practice reconstruction in bioarchaeology – an oxygen isotopes study in an animal model
Authors: Lisowska-Gaczorek Aleksandra , Cienkosz-Stepańczak Beata , Furmanek Mirosław , Szostek Krzysztof
Published: November 2023

Research using stable isotopes for the reconstruction of breastfeeding strategies are based on assumptions that have not yet been verified by experimental studies. Interpreting the results of isotope analysis is associated with a certain degree of uncertainty, mainly due to the lack of information on how isotopes are distributed in mothers, breast-fed and weaned offspring. Culinary practices also can affect the interpretation of isotope results.
Considering positive correlation between oxygen isotope composition of drinking water and bone phosphates, experimental studies were carried out using rats as an animal model. The experiment showed that apatites of breast-fed offspring were enriched 1.6‰ in comparison to the values observed in their mothers. In the boiled water model, the difference was 1.8‰. On the basis of the animal model, it was estimated that the difference in 18O between mother and child in the human species may amount to approximately 2.7‰, and long-term intake of boiled liquid food and beverages will not compensate the difference.
The experiment allowed observation of the effect of changes in isotope ratios to a change in trophic levels during breastfeeding and weaning, as well as the additional effect associated with the consumption of isotope enriched water during thermal treatment.
Perlindungan Hukum Nasabah Bank Terhadap Kekeliruan Transfer Dana Akibat Kelalaian Bank
Authors: Ningtyas Fona Aprilia Dwi , Permana Bayu Indra
Published: November 2023

Fund transfers are a solution to the problem of sending money that requires people to carry money from one area to another and reduce the various risks that can occur when transferring money in cash. However, nowadays there are often cases of erroneous transfers of funds in the form of foreign incoming funds where the recipient feels he does not know the information about the sender of the funds, the funds come in suddenly where the recipient customer does not feel he is in or has made a transaction with another party which results in transfer of funds to the account. Cases of errors in customer fund transfers that occur can result in losses experienced and suffered by the customer concerned. This study uses a juridical-normative method, by collecting descriptions and information that can be used in resolving this problem using a statutory approach and a conceptual approach, as well as using sources of primary legal materials and secondary legal materials, as well as methods of collecting legal materials with literature studies. . The status of ownership of funds in a fund transfer is the right of the recipient of the funds as long as it can be proven that the funds are his right and are not an error in the transfer of funds. Meanwhile, this form of legal protection for errors in fund transfers can also be seen in the bank's responsibility to cancel or issue a new fund transfer order addressed to a recipient who is entitled to and desired by the sender.
Keywords: Legal Protection, Confusion, Fund Transfers, Customers, Banks
In vivo studies of lavender extracts for healing thermal injury in rats
Authors: Organ Adina , Jian Mariana , Cobzac Vitalie , Girbu Vladilena , Cotelea Tamara , Cirimpei Octavian , Kulcitki Veaceslav , Nacu Viorel
Published: November 2023

In recent years, herbal extracts obtained from medicinal plants have gained increasing interest in treatment of wounds. About 450 plant species having wound healing properties have been identified. The present knowledge of the wound healing process comprises coagulation, inflammation, proliferation, formation and accumulation of fibrous tissues, collagen deposition, epithelialization, contraction of wound with formation of granulation tissues, remodeling and maturation [1]. The selection of research methods was carried out in accordance with objectives of the work: determining of regeneration properties of Lavandula angustifolia extract fractions with assessment of the influence on the regeneration of thermal injuries of the epithelium in laboratory animals, through the evaluation, when they are administered in different fractions. Sodium carboxymethylcellulose gels containing 5% lavender extracts were investigated in this study for regenerative properties in thermal injury repair in laboratory rats. "Levomicol" ointment was administered as a control. Gel formulations were administered daily to lesions in white rats. Animals were divided into 6 groups of 3 individuals. After the observation period (of 7 days) the animals were euthanized and the epithelium harvested for the study of regeneration indices. As a result of this study, the histological sections studied in hematoxylin and eosin (HE) staining showed partial regeneration both at the epithelial and dermal levels. Regeneration indices have shown that gels containing lavender extracts can increase the proliferation of epithelial cells, the inflammatory processes being decreased.
Synthesis and structure of compounds obtained from the interaction of (+) 3-carene monoterpene with potassium permanganate
Authors: Cojocari Sergiu , Bilan Dmitri , Macaev Fliur
Published: November 2023

At present one of the main features of the chemistry of natural cyclopropanes is determined by the great diversity/variability of their structures and properties. However, the low content of most optically active cyclopropanes obtained from natural sources is a priority and requires the urgent development of readily applicable methods for synthesis from available natural substances, e.g. (+)-3-carene monoterpene 1. A distinctive structural feature of (+)-3-carene is the presence in its molecule of a bicyclic bridge system consisting of methylcyclohexane, 2,2dimethylcyclopropane moieties and a reactive С-С double bond. The main aim of the work is to obtain oxygen-containing functional groups in the (+)-3carene 1 molecule, thus the oxidation properties of (+)-3-carene with permanganate in an acetone solution were studied.It was found that after 3 hours of mixing of the reagents a mixture of products (TLC data) was formed, which allowed the isolation by SiO2 column chromatography of three predominant substances. Less polar was substance 2, in the IR spectrum of which there are characteristic stretching vibration frequencies for the unsaturated ketone (1660 cm-1), for methyl (1370 and 1385 cm-1). In the 1H NMR spectrum, the singlet signals of six protons and three protons of two single methyl groups in a strong field are complemented by one proton signals of three vinyl protons and a two proton signal of the methylene group. These data, combined with 13C NMR data, indicate the structure of (2Z,4Z)-3,6,6-trimethylcyclohepta-2,4-dienone 2. (1R,4S,6S)-4-hydroxy-4,7,7-trimethylbicyclo[4.1.0]heptane-3-one 3. The most polar substance was cis-diol (1S,3S,4R,6R)-3,7,7-trimethylbicyclo[4.1.0]heptan-33,4-diol 4. Thus, it was found that the interaction of monoterpene (+)-3-carene 1 with KMnO4 occurs with the introduction of both one and two oxygen-containing functional groups, and involves both change and conservation of the carene "scaffold".
The alkylation of the amides of dehydroabietic acid
Authors: Pogrebnoi Vsevolod , Pogrebnoi Serghei , Macaev Fliur
Published: November 2023

In this abstract is being discussed the synthesis of new substituted amides of dehydroabietic acid with different bromides in system K2CO3/DMF. It is known fact that many compounds, such as famous isatine 1, have the amide group in its molecule. There is no point in talking about it, because everything is known regarding chemical properties. However, what if there are two amide groups in the molecule at once? Let us see… For our investigation, we used the model of well-known alkylation reaction [1]. As starting material, we used two types of bromide: aliphatic and aromatic – bromoacetone [2] and phenacyl bromide [3], respectively, which reacted with dioxalane 2 [4] in above described conditions [4].The first approach was started from slight excess of corresponding bromide (1.2-1.3 eq.) and the full conversion observed after 3 hours at 40-500C. According to NMR spectrum, the isolated white solids are monosubstituted products – 3 and 4, respectively [4]. Increasing the amount of bromide to 3-4 equivalents didn't change the situation – the TLC showed only monosubstituted compounds. And the last approach was in significantly increasing the amount of bromide (up to 10 equivalents) and heating the reaction mixture above 1000C for several days, resulting a significant drop in the yield of the desired products and the formation of by-products that could not be isolated and characterized. The formation of monosubstituted products can be explained by steric factors – the close location of methyl and carbonyl group to the reaction center at the nitrogen atom in dehydroabietic fragment.
Late stage functionalization of cyclic terpenoids by atom transfer radical addition. A convenient route towards nitrogen heterocycles
Authors: Birca Natalia , Kulcitki Veaceslav
Published: November 2023

Terpens are a class of widely spread natural compounds with a broad range of biological properties, showing ‘drug-like’ chemical properties, including lipophilicity, interesting molecular geometry, alkylating center reactivity etc [1]. Nevertheless, nitrogen-containing terpens, which can show diverse functionality and biological activity in living cells, are rare in natural sources. We present in this communication the atom transfer radical additions performed on relevant terpene derivatives of labdane and drimane framework, compounds 1-3, and resulting in a series of azido-compounds. Carboazidation of correspomding terpenic olefins was carried out with ethyliodoacetate under specific conditions using di-tert-butyl hyponitrite (DTBHN) as free radical initiator and phenylsolfonylazide as the azide radical source [2]. The addition products formed with excellent yields. Subsequent modifications to the azide group, such as catalytic hydrogenation, led to spontaneous lactamization, resulting in the formation of γ-lactam products. Our investigations revealed that stereochemical constraints play an important role in these transformations, both at addition and reduction steps. Following assessment of the interactions of these compounds with biomolecular targets is under way.
Transforming the five-membered ring d in a pregnenolone derivative into a six-membered ring through skeletal rearrangement
Authors: Bilan Dmitri , Cojocari Sergiu , Sucman Natalia , Stingaci Eughenia , Macaev Fliur
Published: November 2023

In pursuit of obtaining steroid derivatives containing a triazole moiety in their structure, a series of reactions was conducted (Figure 1). In these reactions, an intermediate compound was the corresponding azide 3, which was subsequently involved in a reaction with the required alkyne to form a 1,2,3-triazole. In click chemistry reactions, it is well-known that catalysts are one-valent copper salts, which can be generated in situ from copper(II) salts. However, the NMR spectra of the main product, isolated from the reaction mass, did not match the expected results.Figure 1. The procedure for synthesizing azides 3 and 4 Upon analyzing the collected data from 1H, 13C, 15N, HSQC, HMBC, and DEPT spectra, it was concluded that under these conditions, a skeletal rearrangement occurs, where the fivemembered ring D expands to a six-membered one, forming a new compound. To confirm this hypothesis, the starting compound 3 was mixed under similar conditions without the addition of a reagent. As a result, the same compound was isolated, and its spectral data corresponded to the structure of 5, which was confirmed through X-ray structural analysis too.Figure 2. The mechanism of the skeletal rearrangement The mechanism of the skeletal rearrangement of steroid derivatives in the presence of copper(I) ions is presented in Figure 2.
Project technologies as a factor in the development of students’ creative potential
Authors: Grigorieva Elena I. , Sakharova Maria V.
Published: November 2023

Importance. The demand for a creative approach in many fields of activity is revealed, and creativity is also considered as a necessary part of professional training. The actualization of active methods (using the example of project technologies) for the university students’ creative potential development is worked out. Research Methods. The research object is project technologies, the subject is project technologies possibilities to develop the higher educational institutions students’ creative potential. The theoretical basis of the research is an interdisciplinary approach, the research axiological foundations are the subject-activity and functional-activity approach to the educational process. The research empirical basis is the practice of using project technologies in the teaching process. Results and Discussion. The possibilities and features of project technologies for the development of students’ creative potential are considered. The characteristic of the main conditions and necessary components of this process is given. The practice of using project technologies in teaching such disciplines as “Philosophy”, “Cultural codes”, “Great Books”, “History of Sociology” is analyzed. Conclusion. Project activity, developing the individual creative potential, solves an important task of professional training – the development the ability to independently set professional goals and implement their ideas.
Teaching the grammatical side of foreign language speech to future social workers based on mental cards
Authors: Bryxina Iraida E.
Published: November 2023

Importance. The methodological potential of mental cards for interconnected teaching of a foreign language and the specialty of future social workers is considered. This technology, used as part of integrated subject-language teaching of the French language and specialty, helps students visualize and control the material being studied, providing the opportunity to see several ideas in a small space. The theoretical description of mental maps is analyzed, their importance for teaching the grammatical side of foreign language speech and its activation in classes in a non-linguistic university is substantiated.
Materials and Methods. During the study the theoretical analysis of scientific and methodological literature and advanced methodological experience were used; experiential learning; observation; survey; descriptions; elements of quantitative calculations.
Results and Discussion. To create educational mental cards, the following components are proposed: the main idea or purpose of studying the material, secondary (and subsequent) ideas, connections between components, illustrative material, color stimulus, and others corresponding to the topic of the course. An algorithm for working with mental cards has been defined, which includes four main stages, each of which may contain additional stages: informational (organization of work with the topic being studied), technological (working with elements of a mental card, their comprehension, discussion and memorization), procedural (correction of the mental card), final (discussion on authentic text fragments containing studied grammatical structures and their discussion). The following oral and written professional tasks were identified: sketch, testing, abstract, discussion. The feasibility of using mental cards in teaching grammar is confirmed in the experiment conducted by the authors; statistical calculations and questioning of students have proven the effectiveness of the proposed technology.
Conclusion. The effectiveness of using mental cards in the learning process is predetermined by their properties, including clarity (you can view the vocabulary being studied and note shortcomings), attractiveness (aesthetic appearance), timeliness (see what information is missing), possibility of revision (allows you to remember and assimilate the material, identify the causes of possible difficulties). This technology demonstrates a wide range of possible methods for the development of linguistic thinking, both in the field of analyzing vocabulary and grammar in the specialty being studied, and in using it for any stage of work at a non-linguistic university. The effectiveness of using mental cards for the formation of the grammatical side of foreign language speech in situations of professional communication, as well as for increasing motivation for learning a foreign language in the field of professional communication, is noted.
“And on the Crimean coast they finished their exodus”: the fate of fellow officers at the end of the “Great” Civil War
Authors: Kanishchev Vladimir V.
Published: November 2023

Importance. The life trajectories of the Russian Imperial Army officers group who stayed in the Crimea at the final stage of the “Great” Civil War are considered. The importance of the research lies in the fact that the sample is based on fates of the officers who served in various units in the Tambov governorate on the eve of the World War I and were subsequently plunged into the abyss of the national strife.
Materials and Methods. The research is based on the materials of archival sources, Memory Books and electronic databases. The work is based on the prosopographical research method, which allowed to establish the life trajectories of the studied characters.
Results and Discussion. It is found that of all the participants of the sample, only the revolution opponents were in Crimea. It is interesting that they were in each of the consideredunits. It is not found any mention of fellow soldiers who enlisted in the Workers’ and Peasants’ Red Army and fought on the peninsula.
Conclusions. The denouement of the “Crimean Epopoeia” for most of them also looks typical in many respects. Someone was able to leave the peninsula, and for some it became “final residence”. In some cases it is also possible to trace the emigrant path of mentioned characters, which, has a very serious significance.
Microdemographic processes in the agrarian field: growth points and islands of stability
Authors: Ilyin Alexey Y. , Kanishchev Vladimir V.
Published: November 2023

Importance. In modern conditions of depopulation and migration outflow of rural population it is important to study the facts of sustainable development of rural population and factors of such stability.
Materials and methods. The research is based on the published and Internet statistical materials of the settlement level. A sample of several dozens of urban-type settlements and suburban rural councils located in rural areas is created as an object of study. Sociological materials on the issue of marriage of rural population are also involved.
Results and Discussion. The research show that the population dynamics in the selected group of settlements at the beginning of the 21st century developed unevenly. Along with the reduction in the number of residents in most settlements and villages there were facts of the indicator growth due to migration inflow. The cases of population growth and decline in some segments of the last decades indicate the non-linearity of demographic processes. The revealed order of figures in the indicators of natural and migratory movement of residents of the studied settlements indicates the absence of extreme values. The study of the problem of economic employment of residents of suburban rural settlements and urban-type settlements show a considerable number of jobs to retain the population in these settlements.
Conclusions. Demographic data at the micro-level do not allow us to speak about widespread depopulation and devastation of the rural population of the Tambov Region. But “islands of stability” and “growth points” should be studied more thoroughly, using interdisciplinary approaches of humanitarian, socio-political, natural and other exact sciences.
The effects of context of learning on the perception of Spanish stress by Japanese speakers
Authors: Sierra Elkin , Loyola Gabriela Martinez , Kimura Takuya , Stevenson Ryan , Rao Rajiv , Rafat Yasaman
Published: November 2023

This study explores the effect of context of learning on the perception of Spanish lexical stress. Spanish is considered a mixed system (with predictable and unpredictable stress) and a stress-accent language. Tokyo Japanese is a good example of a language without stress, but with pitch-accent. Two groups of Japanese speakers (20 in Bogotá and 25 in Japan) and a control group of 20 Spanish speakers completed a stress identification task, consisting of nine sets of 3 syllable accentual minimal triplets with each having an oxytone (e.g., nabidó), a paroxytone (e.g., nabido), and a proparoxytone (e.g., nábido). The results demonstrated that there was a significant effect of context of learning, with learners in Japan (88%) having a significantly (p=0.000) higher error rate than the learners in Colombia (60%). This study sheds highlights the effect of context of learning on L2 speech learning by demonstrating that immersion can enhance L2 stress perception.
CARICA PAPAYA L. WITH SUTURE WOUND HEALING IN MICE EXPERIMENTAL ANIMALS
Authors: Istiqomah Dani , Azizah Nurul , Purwanti Yanik , Rinata Evi
Published: November 2023

Background: Stitches are a condition in which skin tissue damage results from incisions or surgery and trauma. Carica Papaya Linn contains flavonoids which are efficacious as anti-inflammatory or antiseptic in inhibiting bacterial growth. Carica Papaya Linn is effective in repairing cells damaged by free radicals. The purpose of this study was to see the effectiveness of papaya leaf extract (Carica Papaya Linn) against stitches. Method: This research was quantitative research with a True Experimental design with the one group post-test method using the REEDA scale assessment. The population in this study were mice (Mus Musculus) which were divided into 5 groups, control group, nebacetin group, 5% test group, 10% test group and 15% test group. Research was conducted in the Lab. Medical Laboratory Technology at Muhammadiyah University of Sidoarjo and for making extracts from the Faculty of Mathematics and Natural Sciences, Surabaya State University. Data was collected and then the results were analysed using the One Way ANOVA statistical test. Result: The results of the statistical test showed a value of P = 0.000 in the 7th day group, which means there was a difference in each group of mice and the mean results showed the lowest result was 0.2 in the 15% extract which stated the best wound healing. Conclusion : The conclusion of the study was that there was an effect of giving papaya leaf extract (Carica Papaya L.) on wound healing in experimental mice.
BINAHONG [Anredera cordifolia (Tenore) Steenis] LEAF INFUSA FOR SUTURE WOUND INFECTION CONVALESCENCE
Authors: Baso Siti Nur Azizah Sucitra , Azizah Nurul , Rosyidah Rafhani , Rinata Evi
Published: November 2023

Background: Postpartum infections are the top 4 main causes of the high maternal mortality rate in Indonesia at 2022 of 183 per 100,000 live births. Efforts to prevent complications due to infection of puerperal suture wounds with pharmacological therapy using antibiotics and antiseptics, as well as non-pharmacological ones using plant extracts. Binahong is believed to contain flavonoids, terpenoids, saponins, tannins, essential oils, and alkaloids, which are especially useful in healing wound infections. The aim of the study was to determine the effectiveness of infusion of binahong leaves (Anredera cordifolia (Tenore) Steenis) on the healing of suture wound infections in rats (Rattus norvegicus) experimental animals. Method: The research method was a true-experimental posttest only control group design, the study was conducted from June to August 2023 at the Microbiology and Pharmacology Laboratory of Muhammadiyah Sidoarjo University, the research variables were binahong leaf infusion and healing of suture infection, assessment and data collection using the REEDA scale instrument, statistical analysis with the one-way ANOVA, and post-hoc follow-up tests. Result: The results showed p <0.05, so there was a significant effect of giving binahong leaf infusion on the healing of suture wound infections. In terms of the difference in the mean value and the results of the post-hoc significant difference test, it appears that the 5% binahong leaf infusion group showed the most effective results in healing suture wound infections and was significantly different from the negative control group with less effective healing of suture infections. Conclusion : This is in line with research that states that the group given a 5% concentration of binahong extract was more effective than the group with a higher concentration. Thus, administration of a 5% concentration of binahong leaf infusion can be an alternative for healing suture wound infections due to the important content in it in the form of flavonoids, terpenoids, saponins, tannins, essential oils, and alkaloids. Further research is needed with lower concentrations of binahong leaf infusion to find out the minimum concentration that can have a good effect on the convalescence of suture wound infections.
THE EFFECT OF ALOE VERA COMPRESSES ON BREAST ENGORGEMENT PAIN IN POSTPARTUM MOTHERS
Authors: Safaah Nurus , Erna Eka Wijayanti  , Umu Qonitun
Published: November 2023

Background: Breast engorgement is an unpleasant physiological condition characterized by swelling and pain in the breasts. Treatment to reduce breast engorgement uses aloe vera which contains aloin and emodin which can function as analgesics. The purpose of this study was to determine the effect of aloe vera compresses on breast engorgement in postpartum mothers. Methods: This was a true-experimental design with a pre-post test design with a control group. The independent variable is Aloe vera compress while the dependent variable is Breast engorgement pain. The population in this study were all postpartum mothers at the Merakurak health center, The sample in this study was 32 postpartum mothers at the Merakurak Community Health Center who met the inclusion criteria, The sampling technique used consecutive sampling and data collection using observation sheets involving 32 postpartum mothers. The statistical tests were undertaken using the Wilcoxon and Mann-Whitney tests. Results: The results of the study showed that the majority of postpartum mothers were aged 20-35 years, in a total of 23 mothers (93.6%). Most of them (62.5%) had a high school educational background, and most of them (62.5%) had a history of multiparas. Based on the results of the study, there is an effect of giving aloe vera compresses on breast engorgement in postpartum mothers (p-value 0.000). Conclusion: Aloe vera compress therapy can be used by postpartum mothers to treat breast milk retention because aloe vera contains anthraquinone which contains aloin and emodin which can function as analgesics. Aloe vera compress can be done Recommended as a complementary therapy for breast engorgement pain.