bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Factors Determining Korea's Agricultural Export Competitiveness: A Focus on the Panel Spatial Gravity Model
Authors:   Korea Association for International Commerce and Information, Cho Sung-Je
Published: January 2025

This study analyzes the determinants of Korea's agricultural export competitiveness using a panel spatial gravity model. With K-Food exports reaching approximately USD 13 billion in 2023, the research highlights key factors for strengthening Korea's agricultural export competitiveness and provides strategic directions as a foundation for the medium- and long-term development of Korea's agricultural exports. Historically, agricultural exports accounted for a small proportion of Korea's total exports. However, the remarkable growth of agricultural exports today, alongside the emergence of K-Food, can be attributed to the cumulative experience and strategies employed in the past. This underscores the importance of maintaining a strong foothold in traditionally established markets while actively leveraging the concept of K-Food, which integrates agricultural products with K-Culture, rather than viewing agricultural exports solely as the trade of raw goods.\n\nBased on the findings derived from the analysis of Korea's agricultural export competitiveness using the panel spatial gravity model, the study presents the following recommendations. First, strategies for sustaining and expanding markets should be developed by utilizing historical export data. Second, logistics networks must be strengthened to overcome physical and infrastructural barriers. Third, mutually complementary trade relations should be established, reflecting regional cooperation and spatial dynamics. By adopting these approaches, Korea can respond effectively to the evolving demands of the international market and solidify its position as a leading powerhouse in agricultural exports.
Global Economic Prospects, January 2025
Authors:   World Bank
Published: January 2025

Global growth is expected to hold steady at 2.7 percent in 2025-26. However, the global economy appears to be settling at a low growth rate that will be insufficient to foster sustained economic development—with the possibility of further headwinds from heightened policy uncertainty and adverse trade policy shifts, geopolitical tensions, persistent inflation, and climate-related natural disasters. Against this backdrop, emerging market and developing economies are set to enter the second quarter of the twenty-first century with per capita incomes on a trajectory that implies substantially slower catch-up toward advanced-economy living standards than they previously experienced. Without course corrections, most low-income countries are unlikely to graduate to middle-income status by the middle of the century. Policy action at both global and national levels is needed to foster a more favorable external environment, enhance macroeconomic stability, reduce structural constraints, address the effects of climate change, and thus accelerate long-term growth and development.
Prosociality in Microtransit
Authors: Sundaresan Divya , Watson Akhira , Bardaka Eleni , Lee Crystal Chen , Mayhorn Christopher B. , Singh Munindar P.
Published: January 2025

We study (public) microtransit, a type of transportation service wherein a municipality offers point-to-point rides to residents, for a fixed, nominal fare. Microtransit exemplifies practical resource allocation problems that are often over-constrained in that not all ride requests (pickup and dropoff locations at specified times) can be satisfied or satisfied only by violating soft goals such as sustainability, and where economic signals (e.g., surge pricing) are not applicable—they would lead to unethical outcomes by effectively coercing poor people.
We posit that instead of taking rider preferences as fixed, shaping them prosocially will lead to improved societal outcomes. Prosociality refers to an attitude or behavior that is intended to benefit others. This paper demonstrates a computational approach to prosociality in the context of a (public) microtransit service for disadvantaged riders. Prosociality appears as a willingness to adjust one’s pickup and dropoff times and locations to accommodate the schedules of others and to enable sharing rides (which increases the number of riders served with the same resources).
This paper describes an interdisciplinary study of prosociality in microtransit between a transportation researcher, psychologists, a social scientist, and AI researchers. Our contributions are these: (1) empirical support for the viability of prosociality in microtransit (and constraints on it) through interviews with drivers and focus groups of riders; (2) a prototype mobile app demonstrating how our prosocial intervention can be combined with the transportation backend; (3) a reinforcement learning approach to model a rider and determine the best interventions to persuade that rider toward prosociality; and (4) a cognitive model of rider personas to enable evaluation of alternative interventions.
A Portfolio Approach to Massively Parallel Bayesian Optimization
Authors: Binois Mickael , Collier Nicholson , Ozik Jonathan
Published: January 2025

One way to reduce the time of conducting optimization studies is to evaluate designs in parallel rather than just one-at-a-time. For expensive-to-evaluate black-boxes, batch versions of Bayesian optimization have been proposed. They work by building a surrogate model of the black-box to simultaneously select multiple designs via an infill criterion. Still, despite the increased availability of computing resources that enable large-scale parallelism, the strategies that work for selecting a few tens of parallel designs for evaluations become limiting due to the complexity of selecting more designs. It is even more crucial when the black-box is noisy, necessitating more evaluations as well as repeating experiments. Here we propose a scalable strategy that can keep up with massive batching natively, focused on the exploration/exploitation trade-off and a portfolio allocation. We compare the approach with related methods on noisy functions, for mono and multi-objective optimization tasks. These experiments show orders of magnitude speed improvements over existing methods with similar or better performance.
NEAR-FIELD SPRAY TIP CHARACTERISTICS OF ISO-OCTANE/DIETHYL ETHER BLENDS AS PROMISING GCI FUELS
Authors: Yao Xiaoxin , Wang Ze , Liu Xiao , Huang Zuohua , Law Chung K. , Tang Chenglong
Published: January 2025

Effects of bio-fuel diethyl ether (DEE) addition on the near-field spray tip characteristics of iso-octane
have been investigated at different ambient temperatures experimentally by using high-speed imaging with a long-distance microscope. The near-field spray screening is focused on the early stage of ∼0.2 ms after starting the injection and the measuring length scale is less than 3.0 mm below the nozzle exit. Results show that, first, the DEE blending ratio and ambient temperature significantly affect the state of the previous injection residual fuel, which leads to four typical near-field spray tip patterns: mushroom, umbrella, helmet, and vapor hemisphere, as the liquid phase residual fuel is vaporized. Second,
quantitative description of the near-field spray tip has been conducted. High ambient temperature and DEE blending ratio favor faster tip penetration because of the enhanced residual fuel vaporization and reduced axial obstruction. Finally, different near-field spray tip patterns resulting from the residual fuel state are shown as function of the ambient temperature and DEE blending ratio, followed by a conceptual scheme regarding the state of the residual fuel and its evolution after the start of injection, at different ambient temperatures and DEE blending ratios.
Utilization of Telemedicine for Patients Receiving In-Center Hemodialysis in the United States
Authors: Niu Jingbo , Rosales Omar , Oluyomi Abiodun , Lew Susie Q. , Chertow Glenn M. , Winkelmayer Wolfgang C. , Erickson Kevin F.
Published: January 2025

Key Points

Emergency waivers enacted during the coronavirus disease 2019 (COVID-19) pandemic in the United States enabled kidney care providers to provide hemodialysis visits with telemedicine.

Telemedicine was associated with a somewhat higher frequency of four or more hemodialysis visits per month but not with hospitalizations.

Visit frequency increases were more pronounced when kidney care providers had to travel longer distances to see patients in person.

Background

In March 2020, responding to the COVID-19 pandemic, federal emergency waivers in the United States enabled kidney care providers (nephrologists and advanced practice providers) to substitute face-to-face in-center hemodialysis visits with telemedicine encounters. We examined whether the frequency of kidney care provider visits and hospitalizations were associated with telemedicine use in hemodialysis care.

Methods

We used Medicare claims to identify US patients receiving in-center hemodialysis during the first 16 months of the COVID-19 pandemic. We examined the association between telemedicine use during in-center hemodialysis, the frequency with which kidney care providers visited patients at dialysis four or more times per month, and hospitalizations. We also examined whether the association between telemedicine use and visit frequency varied at facilities located in more remote areas. Multivariable regression models adjusted for patient, physician, geographic, and dialysis facility characteristics along with the frequency with which kidney care providers saw patients at each facility before the pandemic. We focused on kidney care providers who demonstrated knowledge of how to bill for telemedicine visits by using the telemedicine modifier on prior claims.

Results

We identified 1881 providers who saw patients between March 2020 and June 2021 and were definitively using telemedicine. In the adjusted model, a 35% absolute higher use of telemedicine at a facility (representing 1 SD difference) was associated with a 1.4% higher rate of four or more visits (incidence rate ratio, 1.014; 95% confidence interval, 1.007 to 1.022). The association between telemedicine use and visit frequency was stronger where travel distances to facilities were farther (interaction P = 0.01). There was no significant association between telemedicine use and hospitalizations.

Conclusions

The use of telemedicine to care for patients receiving in-center hemodialysis was associated with a slightly higher frequency of four or more visits per month but not with hospitalizations; the association with visit frequency was more pronounced in areas where providers had to travel longer distances to see patients in person.
Hızlı Okuma Eğitiminin İlkokul Dördüncü Sınıf Öğrencilerinin Okuma Hızlarına ve Anlama Düzeylerine Etkisi
Authors: Oktay Kırkkılıç Zeynep , Boyraz Celal
Published: January 2025

Araştırmanın temel amacı, hızlı okuma eğitiminin ilkokul dördüncü sınıf öğrencilerinin okuma hızlarına ve anlama düzeylerine etkisini incelemektir. Bu doğrultuda araştırma, ön test-son test kontrol gruplu yarı deneysel model olarak desenlemiştir. 2023-2024 eğitim-öğretim yılı bahar döneminde gerçekleştirilen araştırmaya Bayburt ili merkez ilçesine bağlı bir devlet okulunun dördüncü sınıf A ve B şubelerinde öğrenim gören öğrenciler katılmıştır. Örneklemi 16 deney, 15 kontrol olmak üzere 31 öğrenci oluşturmaktadır. Deneysel süreçte önce her iki sınıfa ön test olarak Okuduğunu Anlama Başarı Testi uygulanmış ve araştırmacılar tarafından belirlenen metin üzerinden okuma hızı ölçümü yapılmıştır. Deney grubuna araştırmacı tarafından Hızlı Okuma Eğitimi verilmiştir. Deneysel işlem sonrasında veri toplama araçları son test olarak yeniden uygulanmıştır. Araştırma kapsamında ulaşılan verilerin normal dağılıp dağılmadığını incelemek için Shapiro-Wilk normallik testi sonuçları, basıklık-çarpıklık katsayıları, histogram ve kutu grafikleri incelenerek verilerin parametrik testlerle çözümlenmesine karar verilmiştir. Sonuç olarak hızlı okuma eğitiminin okuduğunu anlama başarısını ve okuma hızını olumlu yönde etkilediği görülmüştür.
Irony, end of the word and authority. About Witold Gombrowicz’s Premeditated crime
Authors: Całbecki Marcin
Published: January 2025

The article Irony, end of the word and authority. About Witold Gombrowicz’s “Premeditated crime” is an interpretation of the prewar novel, written by the author of Ferdydurke. The context of the reading is the category of the irony, that is treated in the historical-cultural order. The destructive-creative potential of this communication’s category, used by Gombrowicz, show, how the ironical subject is involved in the political reality. The goal of this activity ist the authority and the establishing of rules in the nominalistic world.
Association between triglyceride-glucose (TyG) index and risk of depression in middle-aged and elderly Chinese adults: Evidence from a large national cohort study
Authors: Xu Zhang-Yang , Zheng Hong , Pan Zi-Jun , Hu Shou-Yi , Wang Yun-Xia , Su Wen-Jun
Published: January 2025

Insulin resistance (IR) has been proposed as a contributing factor to major depressive disorder (MDD), with previous studies reporting a positive correlation between triglyceride-glucose (TyG) a proxy indicator of IR and MDD. However, limited information is available regarding their longitudinal association. This study aimed to clarify the connection between TyG levels and depression risk, as well as explore its predictive potential. A total of 3021 participants without a prior history of depression were recruited from the China Health and Retirement Longitudinal Study and followed for seven years. Participants were categorized into tertiles based on their TyG levels. The cumulative hazard of depression was analyzed using Kaplan–Meier curves, while cox regression analyses and multivariable-adjusted restricted cubic spline (RCS) curves were employed to assess the relationship between TyG levels and depression risk. Stratified analyses across various subgroups were also conducted to confirm the robustness of the conclusions. Over the follow-up period, 1782 participants (58.9%) developed depression, with incidence rates of 30.2%, 34.0%, and 35.8% in tertiles 1, 2, and 3, respectively. After adjusting for confounding factors, each 1-unit increase in TyG was associated with a significantly higher risk of depression. RCS curve analysis revealed a compelling dose-response relationship between TyG levels and depression susceptibility. These findings indicate that elevated TyG levels are strongly associated with an increased risk of depression and could serve as a reliable biomarker for assessing depression risk. These insights provide valuable guidance for developing more effective strategies for the prevention and treatment of depressive disorders.
POWERHOUSES OF SERVICE INDUSTRY IN EUROPE: THE CASE OF SPAIN
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Ignatiev Pavlo , Tsyrfa Iuliia ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: January 2025

Along with France, Spain is considered the European leader in the field of service economy because of record-breaking numbers of foreign tourists, logistic infrastracture of world class and developed net of sea ports that serve as vital intermediaries in the trade between Europe and Africa. The article deals with the statistics that justifies the tourist success of the country and tries to explain how it became so prosperous, while using its rather limited economic potential.

The authors analyze the peculiarities of Spain whose territory consists of the mainland, the Balearic Islands and the Canary Islands, and also belongs to the list of world leaders by the number of UNESCO World heritage sites and the beaches under the ‘Blue Flag’. Since the country’s culture has absorbed the heritage of several eras and different peoples who lived in the Iberian Peninsula, it is interesting both for lovers of antiquity and historical architectural heritage and for admirers of modern cultural trends.

The article underlines an exceptional contribution of aviation industry in the development of tourism, while simultaneously underscoring the importance of the developed net of bullet trains that belongs to the list of the largest in Europe, as well as the cooperation of this state with the European countries that are recognized as leaders in the field of aviation services.

Such topics as the Spanish language educational establishments and famous festivals that allow a certain category of holidaymakers arranging their own leisure time are also highlighted.

The authors believe that transit importance of Spain being at the crossroads between Morocco with its imperial towns, Andorra with its large duty-free zone and Portugal that is famous for its historic towns, windsurfing facilities and developed wine industry contributes even more to its resounding tourist success.

In the final count, one should claim that sophisticated service industry plays an important role in the Spanish economy by reducing, at least in seasonal terms, the high level of unemployment that is the second-worst in the EU only after Greece. Its contribution is monetary terms is also among the largest in the world.
Feasibility of acoustic arthrometry in arthroplasty
Authors: Tashtanov Baikozho R. , Rajfeld Mikhail A. , Vasyukov Vasily N. , Pavlov Vitaliy V. , Korytkin Andrey A.
Published: January 2025

A registers shows an annual increase in the volume of primary arthroplasties, and the number of revision surgeries is increasing respectively. In the long-term results, the number of revisions due to aseptic loosening or failure of the implant (fracture, cracking) is the overwhelming majority. The relevance for early detection of loosening endoprostheses components has become one of the priority research areas in orthopedics. Recently, the interest to the medical community in a diagnostic method based on acoustic or vibration arthrometry has been growing again. The method of acoustic arthrometry (AA), being non-invasive, portable and safe, is more informative under certain conditions in recognizing and displaying the destruction of the implant or the bone-implant system in more detail, contributing to the early diagnosis of implant failures. Aim of this study is to review a state of the art and role of diagnostic acoustic arthrometry (AA) in the hip arthroplasty. Thirty-one technologies have been proposed and despite efforts, none of them has been included in the number of generally accepted medical studies, as all of them have significant limitations, such as: dependence on the density of soft tissues surrounding the endoprosthesis, unresolved issue of the location of sensors. Moreover, most of them have not been tested in vivo, which would show their real potential for further integration into the medical system. Nevertheless, most experimental studies have demonstrated positive results in the diagnosis of loosening, cement mantle failure and component breakage in hip arthroplasty. To overcome these limitations, further studies both in vitro and in vivo, recruitment of a defined cohort of subjects and formation of a database are needed.
Anatomic characteristics of the lacrimal sac and adjacent bony structures–a computed tomographic-dacryocystography research
Authors:   Eye Institute and Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai 200031, China; NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai 200031, China, Cui Xin-Han , Zhang Li-Min ,   Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, China, Qiu Ji-Ni ,   Eye Institute and Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai 200031, China; NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai 200031, China, Zhang Chao-Ran ,   Eye Institute and Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai 200031, China; NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai 200031, China, Wang Yan ,   Eye Institute and Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai 200031, China; NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai 200031, China
Published: January 2025

AIM: To describe the anatomic characteristics of the lacrimal sac and its adjacent bone structures and to provide surgical recommendations for endoscopic dacryocystorhinostomy (EN-DCR).
METHODS: This retrospective comparative study involved 118 sides with complete nasolacrimal duct obstruction and 83 unaffected sides from 126 patients. Computed tomographic-dacryocystography (CT-DCG) scans were performed before lacrimal surgery, and image reconstruction was used to obtain continuous 0.75-mm axial, coronal, and segmental sections for review. The morphology of the lacrimal sac and its relationship with adjacent bony structures were determined for measurement, as well as the obstructed location.
RESULTS: The height of the lacrimal sac was 12.99±2.10 mm in this study. The operculum of the middle turbinate (OMT) was located vertically in the lower third of the lacrimal sac. Horizontally, the junction between the maxillary bone and the lacrimal bone (MB-LB) was close to, mostly (60.2%) posterior to, the lacrimal sac. The uncinate process was more frequently attached to the lacrimal bones (75.1%). The obstructions were generally located around the entrance of the nasolacrimal duct (NLD). However, some were placed higher, with 7.63% blocked not lower than the OMT. There was a negative correlation between the diameter of the lacrimal sac and the level of obstruction (r= -0.35, P<0.01).
CONCLUSION: In this study, the OMT and MB-LB can be served as the landmarks in EN-DCR. Partial uncinectomy should be performed in most cases. The obstructions were generally located around the entrance of the NLD, but some extreme individual variations strongly implies the importance of CT-DCG scanning before surgery.
Comparison of the effect of ranibizumab in retinal vein occlusion and macular edema with different optical coherence tomographic patterns
Authors:   Department of Ophthalmology, the Fourth Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu Province, China, Xu Yue , Song Ze-Yu ,   Department of Ophthalmology, the Fourth Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu Province, China, Zhou Xiao-Yu ,   Department of Ophthalmology, the Fourth Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu Province, China, Zhang Jia-Ju ,   Department of Ophthalmology, the Fourth Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu Province, China, Liang Juan ,   Department of Ophthalmology, the Fourth Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu Province, China
Published: January 2025

AIM: To explore the morphological and functional parameters to evaluate the effectiveness of intravitreal injections of ranibizumab (IVR) in treating macular edema (ME) secondary to retinal vein occlusion (RVO).
METHODS: This retrospective study involved 65 RVO patients (65 eyes) who received IVR and were followed-up for more than 3mo. ME was categorized into cystoid macular edema (CME), diffuse retinal thickening (DRT), and serous retinal detachment (SRD) according to optical coherence tomography (OCT) images. The comparison of best corrected visual acuity (BCVA; logMAR) and central macular thickness (CMT) among different follow-up points and those among 3 groups were performed by Kruskal-Wallis test. The correlation between BCVA and baseline parameters during treatment was analyzed using Spearman correlation analysis.
RESULTS: BCVA tended to improve in all groups, with marked improvement in CME and DRT groups. CMT showed the greatest reduction after 1wk, and remained stable over the following 3mo. DRT patients had the worst BCVA and the highest CMT at baseline, but the differences became smaller after IVR treatment. CMT in SRD group was significantly better than in CME and DRT groups 3mo after IVR. Most patients of CME and SRD groups transitioned to a normal pattern at 3mo follow-up. DRT patients were most likely to transform into the other morphological groups, while SRD patients showed minimal transitions. BCVA at baseline was identified as the most important prognostic indicator in all 3 groups. Additionally, DRT patients with a longer clinical course, higher CMT and central retinal vein occlusion (CRVO) tend to exhibit worse BCVA after treatment. In addition, CRVO patients are more likely to have worse BCVA at 2 and 3mo follow-up compared with branch retinal vein occlusion (BRVO) patients in CME group. SRD patients with higher baseline CMT were prone to experiencing worse BCVA after treatment.
CONCLUSION: The effectiveness of IVR is strongly correlated with baseline BCVA in all 3 groups. Baseline parameters including clinical course, CMT, and RVO position are also useful in predicting the BCVA at different time points after treatment.
COVID-19’s effects on microvascular structure in a healthy retina: an OCTA study
Authors:   Department of Infectious Diseases and Clinical Microbiology, Katip Celebi University Ataturk Educating and Research Hospital, Izmir 35360, Türkiye, Kiratli Kazim , Guven Yusuf Ziya ,   Department of Ophthalmology, Katip Çelebi University Atatürk Educating and Research Hospital, Izmir 35360, Türkey, Akay Fahrettin ,   Department of Ophthalmology, Health Sciences University Gülhane Educating and Research Hospital, Ankara 06010, Türkiye, Aysin Murat ,   Department of Public Health, Balikesir University Faculty of Medicine, Balikesir 10230, Türkiye
Published: January 2025

AIM: To examine the subclinical alterations in the retina and choroid between patients with 2019 coronavirus disease (COVID-19)-related lung involvement and the healthy control group.
METHODS: In this prospective case-control study, 85 cases with lung involvement due to COVID-19 and 50 healthy cases were included. Best-corrected visual acuity, intraocular pressure measurement, and anterior and posterior segment examination were performed on both eyes for each individual. Choroidal and retinal changes were examined and recorded by optical coherence tomography angiography.
RESULTS: All choroidal thickness measurements of the COVID-19 group showed no statistically significant difference when compared to healthy individuals. When vascular density and perfusion density values were compared, there was a decrease in the average of these values in the COVID-19 group, although it was not statistically significant (P=0.088, P=0.065 respectively). When the fovea avascular zone (FAZ) area values were compared, the average was 0.57±0.38 in the COVID-19 group, while it was 0.54±0.24 in the control group.
CONCLUSION: Although our data are not statistically significant, the decrease in vascularity and perfusion and the accompanying FAZ expansion are detected in the acute period (1st month). These changes may anatomically alter the retina in the long term and affect functional vision. Future ischemia-related alterations in the retina caused by a prior COVID-19 infection may arise in situations without comorbidities and may require concern in the patient’s systemic assessment.
New perspectives on DNA methylation modifications in ocular diseases
Authors:   Department of Pathology, Yichang Central People’s Hospital, the First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, Hubei Province, China, Zong Fei-Fei , Huang Guang-Kun ,   Department of Ophthalmology, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China, Pan Meng ,   Shaanxi University of Chinese Medicine, Basic Medical College, Xianyang 712046, Shaanxi Province, China, Hu Hao ,   The Second People’s Hospital of China Three Gorges University, the Second People’s Hospital of Yichang, Yichang 443000, Hubei Province, China, Song Shi-Yi ,   The Second People’s Hospital of China Three Gorges University, the Second People’s Hospital of Yichang, Yichang 443000, Hubei Province, China, Xiao Liang ,   Department of Pathology, Yichang Central People’s Hospital, the First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, Hubei Province, China, Wang Ru-Weng ,   The Second People’s Hospital of China Three Gorges University, the Second People’s Hospital of Yichang, Yichang 443000, Hubei Province, China, Liang Liang ,   The Second People’s Hospital of China Three Gorges University, the Second People’s Hospital of Yichang, Yichang 443000, Hubei Province, China
Published: January 2025

The methylation of DNA is a prevalent epigenetic modification that plays a crucial role in the pathological progression of ocular diseases. DNA methylation can regulate gene expression, thereby affecting cell function and signal transduction. Ophthalmic diseases are a kind of complex diseases, and their pathogenesis involves many factors such as genetic, environmental and individual differences. In addition, inflammation, oxidative stress and lipid metabolism, which abnormal DNA methylation is closely related to, are also considered to be major factors in eye diseases. The current understanding of DNA methylation in eye diseases is becoming more complex and comprehensive. In addition to the simple suppression of gene expression by hypermethylation, factors such as hypomethylation or demethylation, DNA methylation in non-promoter regions, interactions with other epigenetic modifications, and dynamic changes in DNA methylation must also be considered. Interestingly, although some genes are at abnormal methylation levels, their expression is not significantly changed, which indirectly reflects the complexity of gene regulation. This review aims to summarize and compare some relevant studies, and provide with new ideas and methods for the prevention and treatment of different eye diseases, such as glaucoma, retinoblastoma, and diabetic retinopathy.
Photobiomodulation in ocular therapy: current status and future perspectives
Authors:   Al-Mustaqbal University, College of Science, Hillah 51001, Babylon, Iraq; Lumedico Eye Clinics Düsseldorf Germany, Münsterstraße 96, Düsseldorf 40476, Germany, Chichan Hasan , Michalakis Konstantinos ,   Lumedico Eye Clinics Düsseldorf Germany, Münsterstraße 96, Düsseldorf 40476, Germany, Kanal Levent ,   Lumedico Eye Clinics Düsseldorf Germany, Münsterstraße 96, Düsseldorf 40476, Germany
Published: January 2025

Photobiomodulation has been known to have potential medicinal effects for ages. It involves the use of specific wavelengths to target specific regions in the cell. Different health conditions have been reported to be treated with exposure to light such as cardiovascular conditions, inflammatory diseases, infectious diseases, and most importantly ocular diseases. This review specifically targets the treatment of retinal diseases including age-related macular degeneration, diabetic macular edema, myopia and acute retinal light injury with photobiomodulation. Red light is used in this therapy since this wavelength has lower frequency and hence minimal chance of causing any damage. Red light has the potential to penetrate cellular structures such as mitochondria and facilitate cellular processes. For ocular diseases, the target wavelength ranges between 630 to 800 nm. In most of the cases the primary target for red light is the cytochrome C oxidase enzyme in mitochondria, which alters the gene expression and promotes cellular energy production. Clinical evidence shows improvement of visual activity and reduction in thickness of retina post treatment. Future prospects of photobiomodulation involve target-specific treatment, combinational therapy to treat complex retinal diseases including gene therapy, and longitudinal studies to predict long-term efficacy and the chance of any recurrence in the patients. Hence the future of photobiomodulation holds significant potential in medicine especially in ocular diseases characterized by progress in research, technology, and clinical trials.
Sestavinske in skladenjske prenovitve frazemov v izbranih stripih Mikija Mustra
Authors: Markežič Tjaša
Published: January 2025

Stripi kot zgodbe, prikazane z zaporedjem slik in z besedilom navadno v oblačkih, predstavljajo bogat vir jezikovno-slogovnih posebnosti: tujejezičnih prvin, priložnostnic, besednih iger, ironije, onomatopoije, slogovno zaznamovanih besed in tudi frazemov. V prispevku se osredotočamo prav na frazeme v izbranih stripih slovenskega avtorja Mikija Mustra. V številnih stripih pa gre za prenovitev katerega od znanih in uveljavljenih frazemov, ki so, kljub svoji modifikaciji, dovolj očitni in prepoznavni, da brez težav razberemo njihovo izhodiščno obliko. Zbrani primeri vsebujejo inovativne posege v frazeme, kar zaradi izvirnosti in humornosti pritegne naslovnikovo pozornost. Ob zavedanju, da imajo frazeološke prenovitve v besedilu prav poseben učinek, opazujemo enostopenjske (znotraj- in zunajfrazemske), večstopenjske (sestavljene in razstavljene) in križanjske prenovitve ter razmišljamo o njihovem namenu in učinku v besedilih; frazemi s prenovitvijo ustrezajo času in okolju stripovske zgodbe ali poudarijo govorne posebnosti književnih likov.
Drugačenje v otroški in mladinski literarni vedi
Authors: Zavrl Andrej
Published: January 2025

Sodobna otroška in mladinska književnost pogosto tematizira različne oblike oviranosti ter nevečinske identitete in osebne okoliščine. Obenem so te teme in literarne osebe posebej v literarni vedi in kritiki še vedno označene za »drugačne« oziroma »problemske« (ali celo »tabu«), to pa so oznake, ki vzpostavljajo in utrjujejo razmerja moči med družbeno normo in vsem, kar od nje odstopa, ter krepijo (nezavedne) predsodke in stereotipne predstave, da je vse, kar ni v skladu z večinskim razumevanjem sveta, nekako nenormalno oziroma potrebuje strpnost ali sočutje večinske populacije. Prispevek ugotovitve o praktični rabi teh oznak umesti v družboslovno teorijo, posebej koncepte performativnosti (Austin, Butler), orientalizma (Said) in epistemološkega nasilja (Spivak). Zavzema se za (po eni strani) vsebinsko natančnejši in (po drugi strani) jezikovno občutljivejši pristop k poimenovanju in predstavljanju raznolikih tem, identitet in osebnih okoliščin, zato je do navedenih izrazov kritičen, tudi kadar so uporabljeni z dobrimi in (biblio)pedagoško optimističnimi nameni.
Uredniške prakse pri prirejanju (»prevajanju«) slikanic brez besed
Authors: Baloh Barbara , Petrović Vanja
Published: January 2025

Kljub terminološkemu poimenovanju slikanice brez besed vedno vsebujejo določene verbalne elemente. Prav zaradi prevladujoče vizualne plati v slikanicah brez besed je verbalna plat dodatno obremenjena s pomenom in kot taka lahko močno usmerja (širi/zoži) interpretativne možnosti. V tem smislu najmanjša sprememba lahko bistveno vpliva na umetniško strukturo oz. dojemanje dela. Glede na to, da v slovenskem kulturnem prostoru ni veliko znanstvenih prispevkov, ki se teoretično ukvarjajo s slikanicami brez besed, bodo v prvem delu članka predstavljene ključne terminološke težave pri imenovanju žanra in povzete najpomembnejše žanrske značilnosti ter njihov odnos do parabesedila. V analitičnem delu bomo na podlagi analize izbranih originalnih slovenskih izdaj in izdaj v drugih jezikih raziskali splošne uredniške tendence ter pozitivne in negativne uredniške prakse. Poleg tega bomo izpostavili neposredne uredniške intervencije, zaradi katerih prihaja do žanrskih transgresij.
Humic Acid and Sulphur Modulating Phenology, Membrane Integrity, Lipid Peroxidation and Oil Yield in Brassica juncea under Water Regimes
Authors: Manna Toko , Siddique Anaytullah
Published: January 2025

Background: Indian mustard, a key oilseed crop in India, is valued for its diverse culinary and health benefits. It faces significant challenges due to a wide range of abiotic stress wherein climate-induced water stress is one of them, which negatively impacts plant population, morpho-physiological growth and biochemical reactions. Thus not only the seed yield but also oil production is declining. Methods: The current study aimed to evaluate the efficacy of humic acid and sulfur on phenology, membrane integrity, lipid peroxidation and oil yield in Brassica juncea under varying water regimes during the Rabi season of 2022-23 at the research farm of Lovely Professional University. The experiment was conducted in a split-plot design with a total of 16 possible combinations of water regimes and chemical treatments which include humic acid and sulfur. Result: The results indicated that most of the traits were noticed as statistically significant for both factors i.e. water regimes and chemical treatments at p=0.05%. Among the treatments, I3 (Three irrigation) and C3 (Humic acid + Sulfur) were detected as the most effective treatments in terms of percent increase/decrease, resulting highest value over the respective control. The highest % increase was noticed in the initial plant population, final plant population, days taken for maturity, oil content, the moisture content in oil, chlorophyll a, b, a+b and membrane stability index while the reduction in days taken for branching, days taken for the 50% flowering, relative density and malondialdehyde were noticed in the I3 and C3. Thus the findings suggest that the 3 irrigations in combination with humic acid and Sulfur can effectively ameliorate the morpho-physiological growth by increasing the chlorophyll contents, integrity of the cell wall and oil yield in Indian Mustard.
Profiling of Health and Nutritional Components in Jackfruit Variety - ‘Muttomvarikka’
Authors: Divakar Suma , Chandra Neethu
Published: January 2025

Background: Jackfruit or ‘panasa’ scientifically known as Artocarpus heterophyllus. Lam belongs to the family Moraceae. Artocarpus heterophyllus Lam., is a tropical climacteric fruit and is native to Western Ghats of India and common in Asia, Africa and some regions in South America. It is known to be the largest edible fruit in the world. Jackfruit is rich in nutrients including carbohydrates, proteins, vitamins, minerals and phytochemicals. Both the seeds and the flesh of jackfruits are consumed as curries and boiled forms, while the flesh in fully ripened stage can be eaten directly as a fruit. This study was carried out to ascertain the bioactive compounds and nutrients present in the variety of jackfruit released by Kerala Agricultural University -Muttomvarikka. Method: Raw bulb and seeds from fruits of 12 week maturity, along with manifestations like flattening of spikes, change from green to pale green, hollow sound, last leaf in the stalk turning yellow, were considered for selection. The analyses for nutritional and biochemical parameters were conducted using standard protocols. Result: Muttomvarikka ripe seeds recorded higher content of protein (7.99 g) than raw seeds and bulbs. Fibre content of the samples revealed a range of 2.3% to 7.6%. Ripe bulb had higher beta carotene content (5.77 mg/g) than raw bulb and seeds. Carbohydrate content in seeds were higher than bulbs in both raw and ripe stages. Alkaloid content was higher in ripe bulbs and flavonoid content was higher in raw seeds; 19.32 mg of poly phenol was present in 100 g of ripe bulb, which was higher than raw stage. Antioxidant concentration was higher in koozha raw bulbs than ripe bulbs and seeds.
En deuda con el videoclip: un vistazo a las películas de Jonze, Gondry, Dayton y Faris
Authors: Bryson Janice , Péndola Isabel , Sánchez Diego
Published: January 2025

El videoclip es un cortometraje que se difunde por televisión o por internet con tiene fines comerciales. Generalmente estos videos musicales contienen una gran variedad de efectos visuales que los hacen más dinámicos y atractivos, una mezcla de imagen, música y lenguaje verbal. Ello origina una nueva estética en función del tema musical que se representa. Sin embargo, no hay un patrón específico en su creación ya que existen tantos videos musicales como estilos. Prueba de ello son los videoclips dirigidos por Spike Jonze, Michel Gondry, Jonathan Dayton y Valerie Faris. Sin embargo, cuando estos autores dirigen largometrajes, ¿están en deuda con la estética del videoclip?
Kinesik Berkonteks Maluku dalam Film Cahaya Dari Timur Beta Maluku (Kajian Pragmatik)
Authors: Wally Firman , Maisaroh Siti , Martutik
Published: January 2025

Penilitian ini mengkaji kinesik atau studi tentang gerak tubuh dalam komunikasi nonverbal. Penelitian ini bertujuan untuk mendeskripsikan bentuk dan makna kinesik berkonteks budaya Maluku yang terdapat dalam film Cahaya dari Timur Beta Maluku dilihat dari sudut pandang pragmatik. Penelitian ini menggunakan metode deskriptif kualitatif. Sumber data penelitian ini yaitu film Cahaya dari Timur Beta Maluku. Data penelitian ini berupa bahasa nonverbal kinesik. Pengumpulan data dilakukan dengan teknik observasi dan dokumentasi. Adapun teknik analisis data dilakukan dengan (1) memilih dan memeriksa kejelasan dan kelengkapan data yang telah terkumpul, (2) mengidentifikasi data-data yang merujuk pada bahasa nonverbal kinesik (3) mengelompokkan data, (4) mendeskripsikan data, (5) menyimpulkan hasil penelitian. Hasil dari penelitian ini adalah terdapat tiga jenis kinesik yang ditemukan yaitu ekspresi wajah, gerak tubuh, dan posisi tubuh. Ekspresi wajah dalam film ini berupa ekspresi menaikkan alis. Gerakan badan yang terdapat dalam film ini meliputi gerakan tangan, gerakan kepala, dan bentuk gerakan badan menyerupai tarian cakalele. Posisi tubuh dalam film ini berupa posisi mendekat dan menjauh. Penelitian ini menunjukkan bahwa kinesik dalam film tersebut tidak hanya sebagai aspek teknis visual semata, tetapi juga sebagai sarana komunikasi nonverbal yang memperkaya interpretasi penonton terhadap karakter dan suasana budaya Maluku.
Generalized Peritonitis due to Multiple Perforation and Necrotic of Ileum: A Case Report
Authors: Rifqyan Anizar
Published: January 2025

Peritonitis is a life-threatening condition with a mortality rate according to WHO of 5.9 million per year. We report the case of an elderly man who complained of severe pain in the entire abdominal region and the results of a plain abdominal radiograph showed peritonitis and small bowel obstruction. Exploratory laparotomy and ileal resection were performed, and multiple ileal perforations, 120 cm of necrotic ileum and grade IV adhesions were found. There were post-surgical complications of sepsis and the patient died on the seventh post-operative day. Histopathological examination shows images that was not contributory to the diagnosis. There were no features of malignancy or tendency to a specific infection. Non-specific small bowel perforation can be considered as the etiology of peritonitis because there are no specific pathognomonic characteristics. Diagnostic and management of surgical emergencies plays a very important role in patient prognosis.
Impact of the User-Friendliness of BalitaGrow+© on Compliance with Children's Daily Nutrition Column Completing
Authors: Pradewi Ranny Tandria
Published: January 2025

Nutritional imbalances can lead to malnutrition which can affect children's physical and cognitive growth and development. Advances in science and technology has created opportunities for innovation in the form of health applications to help monitor children's growth and development, nutritional status, and children's daily nutritional intake. The factor that influences the intention to use technology is the ease of use. This indicates that the easier the application is to use, the higher a person's interest and compliance will be in using the application regularly. This research aims to determine ease of use effect of the BalitaGrow+© application on compliance filling the daily nutrition column for children in Rambigundam Village, Jember. This research was an analytical observational research with a cross sectional approach using 35 sample size who meet the criteria. Data analyzed with univariate and bivariate test used the Spearman Rank correlation test. The results obtained from 35 respondents showed that 34 people (97.1%) found it easy to use the BalitaGrow+© application and 31 people (88.6%) had good compliance in filling the child's daily nutrition column in the application. The result of statistical analysis showed a significance value of p value >0.05 (0.726). It can be concluded that there was no significant correlation between the ease of use BalitaGrow+© application and compliance filling the daily nutrition column for children in Rambigundam Village, Jember. Researcher suggests for further research to increase the sample size and investigate other influenced factor.
Risk Factor Analysis of Residential Topography and Age on Prostate Cancer Incidence
Authors: Nabilah Aisyah
Published: January 2025

GLOBOCAN stated that prostate cancer is the third most common type of cancer in the world. Previously, prostate cancer incidence rates in Asian populations were lower than Western populations. In recent years, the incidence rate of prostate cancer in Asia has increased rapidly. Indonesia ranks 10th out of 32 Asian countries. Prostate cancer is a multifactorial disease, including age and topographical factors of residence. Prostate cancer risk factors need to be identified to target primary and secondary prevention. Pesticide-specific exposure in rice field areas accumulates in the environment and becomes a pathology. Literature studies from various sources related to these risk factors are still very limited. This study aims to analyze the risk factors of residential topography and age on prostate cancer incidence. An observational analytic study was conducted with a case-control design. 177 samples were obtained by total sampling method, with prostate cancer as the case group and benign prostate hyperplasia as the control group. Age variable parameters are less than or more than 65 years. The residential topography criteria are narrow and large rice fields around the sample residence. The chi-square test result found a significant correlation between residential topography with prostate cancer incidence (p= 0.028, OR= 2.155) and correlation between age factor with prostate cancer incidence (p=0.018, OR=2.187). Age had a 2.009-fold higher risk of prostate cancer incidence than the topography of residence. In conclusion, the topographic profile of the rice field area around the residence and age has a significant risk factor on prostate cancer incidence.
Entre o iconoclasmo e o iconoclash
Authors: Mazim Beatriz Lopes
Published: January 2025

O projeto demonumenta, ligado à Faculdade de Arquitetura e Urbanismo da Universidade de São Paulo (FAU-USP) propõe uma discussão acerca da colonialidade associada a instituições, monumentos e acervos. Uma das seções do projeto, denominada IApiranga, utiliza a inteligência artificial para intervir sobre o acervo do Museu Paulista. Neste artigo, buscamos analisar a seção IApiranga a partir dos conceitos de iconoclasmo e iconoclash situando-a entre os dois. Nesse sentido, o propósito deste trabalho é estudar o potencial iconoclasta do projeto demonumenta que, apesar de operar virtualmente, propõe uma desconstrução e problematização em torno de bens culturais. Propomos uma análise que combine teorias em torno da iconoclastia e história digital a fim de compreender os diálogos possíveis entre as duas áreas.
As imagens também morrem?
Authors: Zacarias Gabriel Ferreira
Published: January 2025

Com crescentes casos de ataques a monumentos no passado recente, o tema da iconoclastia voltou a ser debatido. Mas a iconoclastia que testemunhamos hoje é de fato análoga àquela de períodos distantes no tempo, estudada por autores consagrados como Freedberg e Belting? A hipótese que procuro apresentar é a de que atravessamos um período de transformação epocal na relação com a imagem, e que o próprio conceito de imagem, subentendido de modo genérico à noção de iconoclastia, precisa ser repensado e historicizado. Para tanto, revisito rapidamente a iconoclastia de maio de 68, momento de emergência da sociedade do espetáculo, e proponho, em seguida, algumas indicações teóricas que podem nos ajudar a diferenciar a iconoclastia contemporânea.