bluuebunny/crossref_metadata_2025 huggingface dataset:
DOENÇA INFLAMATÓRIA PÉLVICA: DESAFIOS NO DIAGNÓSTICO PRECOCE E ESTRATÉGIAS TERAPÊUTICAS INOVADORAS
Authors: Silva Layra Nobrega , Pereira Maria Laís Sousa Alencar , Santos Patrick Dean Pereira de Sousa , Andrade Cleidyara de Jesus Brito Bacelar Viana , Veras Matheus Moises , Santos Carlos Eduardo Domingues dos , Guimarães Lucas Soares , Maciel Mirela Paiva , Rebouças João Victor Frota , Pereira João Victor Marinho , Carvalho Thales dos Santos Pires de , Silva Ana Lucia Fatuch e , Mattos Hellen Samilly Sudre , Morato Isadora Filgueiras Santos , Lourenço Gislayne Fontenele Albuquerque
Published: January 2025

A Doença Inflamatória Pélvica (DIP) é uma infecção do trato reprodutivo feminino que envolve a inflamação do útero, das trompas de falópio e dos ovários, podendo se espalhar para os órgãos pélvicos próximos. O diagnóstico de DIP continua a ser complicado por sua ampla gama de apresentações clínicas e pela falta de métodos de diagnóstico rápidos e específicos. Além disso, o tratamento da DIP também enfrenta desafios, uma vez que as opções terapêuticas tradicionais muitas vezes não são suficientes para prevenir complicações a longo prazo. O presente artigo tem como objetivo geral analisar os desafios no diagnóstico precoce da Doença Inflamatória Pélvica e explorar as estratégias terapêuticas inovadoras. A pesquisa é fundamentada em uma revisão abrangente da literatura existente, para a coleta dos dados, foi utilizada a base de dados PubMed e Scielo, a pesquisa foi conduzida com os termos "Doença Inflamatória Pélvica”, “Diagnóstico”, “Tratamento", aplicando o operador booleano "AND". A revisão bibliográfica revelou que a Doença Inflamatória Pélvica (DIP) continua a representar um desafio significativo no diagnóstico precoce e no tratamento eficaz. A natureza assintomática ou com sintomas pouco específicos da doença, aliada à falta de métodos diagnósticos rápidos e precisos, resulta em um diagnóstico tardio e, muitas vezes, em complicações graves, como infertilidade e abscessos pélvicos. Além disso, a resistência bacteriana e a falta de adesão ao tratamento convencional agravam ainda mais o cenário, tornando a gestão da doença complexa e demandando novas abordagens terapêuticas. No entanto, o avanço nas estratégias terapêuticas inovadoras, como o uso de antibióticos de nova geração e terapias combinadas, bem como a implementação de tecnologias de diagnóstico rápido, oferece um cenário promissor para o manejo da DIP. A abordagem multidisciplinar e a educação contínua das pacientes desempenham papéis cruciais na redução das complicações e no aumento da eficácia do tratamento. Dessa forma, é fundamental continuar o desenvolvimento e a implementação de práticas clínicas mais eficazes, com foco na detecção precoce, no tratamento personalizado e na prevenção de sequelas a longo prazo.
Advanced Adsorption in Chemical Engineering: Novel Materials and Techniques for Sustainability
Authors: Deshannavar umesh Basanagouda , A. Kadapure Santosh , G. Hegde Prasad , Karjinni Vilas Vijaya
Published: January 2025

Welcome to the exploration of adsorption in chemical engineering! Within the pages of this book, we embark on a journey through the intricate world of adsorption technology, unraveling its complexities, uncovering its applications, and envisioning its future impact.

Adsorption, a fundamental process in chemical engineering, lies at the heart of numerous industrial and environmental applications. Its ability to selectively capture molecules onto surfaces makes it a versatile tool in purification, separation, and remediation processes. As we delve into the realm of adsorption, we encounter a rich tapestry of principles, materials, techniques, and applications that shape the landscape of chemical engineering.
Prescribing patterns of low-dose aspirin during initial maternity appointments in relation to NICE guideline recommendations: findings from two clinical audits
Authors:   Newcastle Freeman Hospital, Walker Dominique , Dark Graham ,   Newcastle University
Published: January 2025

Two retrospective audits evaluated prescribing patterns of low-dose aspirin in relation to NICE guideline NG133 recommendations during initial maternity appointments at South Tyneside and Sunderland NHS Foundation Trust (STSFT). The first audit in September 2021 and the second in September 2022 each included the first 299 patients attending initial maternity appointments during those months. Maternity records were analysed to evaluate aspirin prescriptions for patients at moderate or high risk of hypertensive disorders during pregnancy, and prescription rates were compared between the two audits. In the 2022 audit, 49 patients were identified as meeting NG133 criteria for aspirin use, and only 31 (63%) were prescribed aspirin. Of the 18 patients (37%) not prescribed aspirin, five later received aspirin, leaving 4.5% of the total cohort (13/299) untreated. The 2021 audit showed a similar pattern, with 5.6% of patients (15/266) remaining untreated despite meeting NG133 criteria for aspirin use. Key risk factors applicable to those not prescribed aspirin included ‘nulliparous,' 'BMI >35,' and 'pregnancy interval >10 years.' Remote consultations were linked to inadequate BMI assessment, with 35% of applicable cases not evaluated. The audit highlights the necessity for ongoing efforts to enhance guideline adherence in clinical practice, especially with the growing prevalence of remote consultations. Addressing the identified discrepancies could lead to improved outcomes for pregnant women at risk of hypertensive disorders.
Cuidados Paliativos, Luto e Saúde Pública: Estratégias para o Acolhimento e Suporte às Famílias enlutadas no SUS
Authors: Liberato Liciane Peixoto Costa , Fernandes Ingridy Tayane Gonçalves Pires
Published: January 2025

Introdução: O luto é um processo natural que pode ter impactos significativos na saúde mental e emocional das famílias enlutadas. No contexto do Sistema Único de Saúde (SUS), a assistência a essas famílias deve ser integrada aos cuidados paliativos, promovendo suporte e acolhimento adequados. A humanização da saúde pública exige estratégias eficazes para minimizar os efeitos adversos do luto e garantir um atendimento mais sensível e eficiente. Objetivo: Analisar a importância dos cuidados paliativos e das estratégias de acolhimento às famílias enlutadas no SUS. Metodologia: A pesquisa foi desenvolvida por meio de uma revisão bibliográfica baseada em artigos científicos, capítulos de livros e dissertações sobre cuidados paliativos e suporte ao luto no SUS. Resultados e Discussões: O suporte ao luto no SUS ainda é limitado, sendo necessário fortalecer políticas públicas voltadas à assistência integral das famílias enlutadas. A implementação de programas de escuta ativa, acompanhamento psicológico e capacitação profissional pode contribuir para um atendimento mais humanizado. Considerações Finais: A incorporação do acolhimento ao luto como parte dos cuidados paliativos é essencial para a melhoria da assistência prestada pelo SUS. Investir na formação de profissionais e na ampliação de redes de apoio pode resultar em resultados positivo na qualidade de vida das famílias enlutadas. Dessa forma, o fortalecimento dessas estratégias contribui para um sistema de saúde mais inclusivo e humanizado.
Editorial: January 2025 Issue of International Journal of Bridge Engineering, Management and Research (IJBEMR)
Authors: Agrawal Anil
Published: January 2025

It is my pleasure to publish the Janyuary issue (1st issue) of Vol. 2 of the International Journal of Bridge engineering, Management and Research.  You can find detailed information about the journal in the inaugural issue of the journal in Agrawal (2024)].  In this issue of the journal, we are pleased to bring to you eight papers in innovative areas of bridge engineering.
‘Where the devil are my slippers?’ – My Fair Lady’s subversion of Pygmalion’s feminist ending?
Authors: Rousseau Aloysia
Published: January 2025

Despite the play being misleadingly subtitled “A Romance in Five Acts,” George Bernard Shaw has always been adamant that Pygmalion’s denouement should not be interpreted as romantic. Yet from the first London production of the play in 1914 to producer Gabriel Pascal’s 1938 film, Alan Jay Lerner’s 1956 libretto and George Cukor’s 1964 adaptation, it seems that no one has been able to resist the urge to romanticize the relationship between Henry Higgins and Eliza Doolittle. This paper focuses on what such romanticizing entails in terms of aesthetics and politics. I will qualify the common assumption according to which Alan Jay Lerner subverted Shaw’s original intentions by trying to demonstrate that the revised ending foregrounds rather than subverts Shaw’s feminist vision.
They Begat the Misbegotten GOP: Finian’s Rainbow and the US Civil Rights Movement
Authors: O'Leary James
Published: January 2025

Between the 1930s and the 1960s, as political discourse and race relations in the United States experienced dramatic upheavals, the conventions of political theater and music changed as well. This essay explores these changes by describing how the 1947 Broadway show Finian’s Rainbow changed when it was adapted into the 1968 film version, directed by Francis Ford Coppola. The original stage production adopted avant-garde styles of 1930s New York theater to make political points in an experimental vein. By the 1960s, however, Coppola no longer recognized the show’s stylistic innovations, and revised the script to be more in line with New Left mores and conventions.
Inventer l’opérette cinématographique : les premiers musicals de Lubitsch
Authors: Pór Katalin
Published: January 2025

Durant les premières années du cinéma sonore, à une période où ni les normes ni les formes du film musical ne sont encore fixées, Lubitsch réalise de manière quasi consécutive trois films musicaux à la Paramount : The Love Parade, Monte Carlo et The Smiling Lieutenant. Cet article s’efforce de démontrer que ces trois projets poursuivent un objectif commun, à savoir l’invention d’une version cinématographique de l’opérette. Puisant dans les sources traditionnelles de l’opérette et s’entourant de connaisseurs de cette forme, Lubitsch s’emploie à rechercher des équivalents cinématographiques de ce qui constitue un principe fondamental de l’opérette, à savoir la construction musicale d’un monde fictionnel. Ces trois films se caractérisent en effet par une volonté de rupture avec la logique de l’attraction et de la performance, au profit d’une vision du cinéma musical qui ferait de la musique l’essence même des êtres et des choses.
How do you deal with a film classic? Tradition and innovation in 42nd Street (1980/2001) and An American in Paris (2014)
Authors: Martina Anne
Published: January 2025

Movie-based shows have surged in recent decades; yet they have often been dismissed as mere commercial enterprises trading in nostalgia and commodity culture. The aim of this paper is to nuance such views by showing that movie-based musicals can be creative, generative and reflective – or not, depending on the production team’s adaptive approach and their adopted aesthetic. To do so, this essay focuses on the stage adaptations of two iconic classical Hollywood films, 42nd Street and An American in Paris. Beyond their obvious similarities (tension between familiarity and novelty induced by the use of a landmark film as source material, “Golden Age” nostalgia, commentary on the Broadway and Hollywood traditions it allows for), I argue that the shows exemplify two different takes on a similar heritage and two radically divergent adaptive processes, conservative revision on the one hand (42nd Street), and modern reinvention on the other (An American in Paris).
Evaluation of the Antimicrobial Activity of cellulolytic Bacillus spp. Isolated from Rice Paddy Fields in the Philippines
Authors:   Polytechnic University of the Philipines, Bangga Jezel , Bańares Jessica Marie ,   Polytechnic University of the Philipines, Lirio Gary Antonio ,   Polytechnic University of the Philipines
Published: January 2025

Drug-resistant strains are becoming a public health problem as antibiotic-resistant diseases become more prevalent in clinical settings throughout the world. Multidrug-resistant microorganisms are constantly adapting to the effects of currently produced antibiotics by inactivating them via a variety of mechanisms. To address this issue, microbial natural sources isolated from various settings are being used to meet the demand for new antimicrobials. On this study, Bacillus species were isolated from rice field soils and their enzyme production and antibacterial activity were determined using plate techniques and agar-well diffusion assays. The results revealed that all isolates synthesized cellulase, with strain BI-AI.1 exhibiting the largest hydrolysis zone of 2.07±1.07 mm. Bacillus cell-free supernatant (CFS) from strains NE-AIII.10, BI-BI.7, and BI-CI.2 also demonstrated antimicrobial activity against Enterococcus faecalis, Micrococcus luteus, and Candida albicans. Only NE-AIII.10 and BI-BI.7 inhibited Gram-negative Klebsiella pneumoniae (8.25±0.12 mm) and Aeromonas hydrophila (2.91±0.72 mm) with p-values of 0.00002 and 0.00006, respectively. Interestingly, Bacillus BI.CI.2 inhibited methicillin-resistant Staphylococcus aureus (MRSA) with a zone of inhibition (ZOI) of 9.83±0.44 mm (p = 0.0005). Bacillus CFS Minimum Inhibitory Concentration (MIC) assays revealed the inhibition of test pathogens at varied concentration ratios. Molecular identification of the top strains NE-AIII-10 and BI-BI.7 using 16s rRNA gene sequence analysis showed similarities of the isolates to Bacillus subtilis. The findings established the presence of cellulolytic Bacillus species in the soils of Philippine rice paddy fields. Additional investigation of the Bacillus CFS is required to confirm the presence of the active components responsible for the inhibitory effects against test pathogens.
Species Listing And Seasonality Of Macrofungi In The Campus Of Isabela State University, Philippines
Authors:   Laboratory of Microbiology and Bio-Industry, College of Arts and Sciences, Isabela State University, Echague, 3309 Philippines, Jacob James Kennard S , Chavez Mhark Jelo G ,   Laboratory of Microbiology and Bio-Industry, College of Arts and Sciences, Isabela State University, Echague, 3309 Philippines, Ignacio Stephanie A ,   Laboratory of Microbiology and Bio-Industry, College of Arts and Sciences, Isabela State University, Echague, 3309 Philippines, Abucay Jose B ,   Protein Chemistry and Biosensor Laboratory, College of Arts and Sciences, Isabela State University, Echague, 3309 Philippines, Kalaw Sofronio P. ,   Center for Tropical Mushroom Research and Development, College of Science, Central Luzon State University, Science City of Muñoz, 3120 Nueva Ecija
Published: January 2025

Macrofungi are important decomposers abundant in forested areas around the world. However, its diversity and seasonality are poorly known in the Philippines. Isabela province is located at the northern part of the Philippines. It is mainly part of the Cagayan Valley region which has wide varieties of living organisms due to its climatical and geographical conditions. Among universities and local colleges in the province, Isabela State University, particularly the Echague Campus (ISU-E), caters the vast agricultural and forest land. This research aimed to enlist the macrofungal species and their seasonality in the campus of ISU-E. Lists of macrofungal species were compared between dry seasons (March-August 2020) and wet season (September 2020 – February 2021). Macrofungal samples were characterized and identified based on their morphology. A total of 31 species belonged to 15 families and 20 genera during the dry season, while 43 species were collected and identified to 19 families and 32 genera during the wet season. The family Polyporaceae had the highest number of species during both seasons. The present study is the first to record the list of macroscopic fungi present in Isabela State University as affected by the change of seasons.
Cytotoxic and apoptotic activities of marine sponge Stylissa massa hexane and methanol extracts against breast cancer cell
Authors:   College of Health and Allied Medical Professions, University of San Agustin, Philippines, Salanio Ramon D , Corpuz Mary Jho-Anne  T ,   The Graduate School, University of Santo Tomas, Manila 1015, Philippines  Department of Pharmacy, Faculty of Pharmacy, University of Santo Tomas, España Blvd., Manila 1015, Philippines,   Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila 1015, Philippines, Vasquez Ross  D. ,   Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila 1015, Philippines,   The Graduate School, University of Santo Tomas, Manila 1015, Philippines
Published: January 2025

Breast cancer is common among Filipino women. Statistical results indicate that one in every 13 Filipino women is expected to develop breast cancer in today’s generation, as stated by the Philippine Society of Medical Oncology (2015). It is associated with the failure of the body to maintain its normal homeostasis and its exposure to harmful chemicals that can result in the proliferation of abnormal cells. The marine environment has abundant potential marine sponges that may play significant roles in drug development for their uniquely structured and unexploited novel compounds. Hence, the in-vitro cytotoxic and apoptotic activity of marine sponge Stylissa massa extract collected from the aquatic resources of Barangay Tando, Nueva Valencia, Guimaras, Philippines, was investigated. The freshly chopped marine sponge was extracted using methanol and partitioned with n-hexane. The extracts were tested on MCF-7, a breast cancer cell line, for their cytotoxicity using MTT Assay. The apoptotic activities were detected using Annexin V-FITC assay kit by fluorescence microscopy and Caspase-Glo 3/7 assays. Both extracts contain alkaloids and amino acids. They inhibited the growth of MCF-7 cells in a dose-dependent manner with an IC50 values of 25 μg/mL and 90 μg/mL for hexane and methanol extract, respectively. These results showed significant cytotoxic and apoptotic activity of hexane and methanol extracts of S. massa. Thus, this marine sponge should be given attention as a potential local source of compounds with apoptotic activity for cancer.
Gambaran Kematangan Karir Anak Binaan Lembaga Pembinaan Khusus Anak (LPKA)
Authors: Wulandari Anastasia , Maslihah Sri , Kosasih Ismawati , Zulnida Eka Fauziyya
Published: January 2025

Penelitian ini dilatarbelakangi oleh banyaknya anak binaan LPKA yang memutuskan bekerja setelah menyelesaikan  masa pembinaan di LPKA. Penelitian ini bertujuan untuk mengetahui gambaran kematangan karir anak binaan LPKA. Lokasi penelitian dilakukan di LPKA Kelas II Bandung dengan sampel sebanyak 20 anak binaan yang akan menyelesaikan masa pembinaan dalam 3-6 bulan lagi. Penelitian menggunakan metode deskriptif kuantitatif dan wawancara untuk menggali kematangan karir anak binaan. Instrumen yang digunakan adalah kuesioner kematangan karir dan dilanjutkan dengan wawancara kepada 9 orang anak binaan.  Hasil pengolahan data deskriptif  kematangan karir anak  binaan didapati 15 % berada pada kategori sangat rendah, 40% rendah, 40% tinggi dan 5 % kategori sangat tinggi. Data tersebut menunjukkan bahwa anak dengan kategori kematangan karir rendah dan tinggi menunjukkan jumlah yang sama. Hasil wawancara pada 9 orang anak yang berada pada kategori tinggi, rendah dan sangat rendah menunjukkan bahwa anak pada kategori tinggi umumnya sudah mampu menyatakan karir yang ingin dicapainya di masa yang akan datang, sementara anak dengan kategori rendah masih ragu dengan karir yang ingin dicapainya. Baik anak dengan kategori tinggi maupun rendah mampu mengenali potensi atau kelebihan yang dimilikinya.
 
Kata kunci: kematangan karir; anak binaan; LPKA
Kent Yüzey Özelliklerinin Kentsel Isı Adası Oluşumuna Etkisi: Gaziantep Örneği
Authors: Şen Ömer , Yalçın Mehmet
Published: January 2025

Günümüz kentleşme hareketleri kent dokusunu değiştirirken bunun bir yansıması olarak kent iklimini de değiştirmektedir. Bu çalışmada iklim değişikliği ve kent bağlamında “kentsel iklim”, “kentsel ısı adası”, “negatif kentsel ısı adası “kavramları tanımlanmış; kent arazi kullanımı / kent arazi yüzeyinin ısı adası/ negatif kentsel ısı adası oluşumuna etkisi Gaziantep ölçeğinde ele alınmıştır. Çalışmada Landsat 8 uydu görüntülerinden ve CORINE Arazi Yüzey/Arazi Kullanım verilerinden faydalanılmıştır. Görüntüler ArcGIS 10.5 programı aracılığıyla sayısallaştırılmış ve haritalara dönüştürülmüştür. Zaman ve mekân ölçeğinde değişimi net görebilmek adına 2013 ve 2023 yıllarına ait temmuz ayı ortalama yüzey sıcaklıkları haritaları ve Gaziantep arazi kullanım sınıfları haritaları oluşturulmuştur. Bölgeye dair çıkarımlar karşılaştırılmalı olarak bu üç harita üzerinden yapılmıştır. Çalışma sonucunda Gaziantep’in merkez ilçelerinden Şahinbey ve Şehitkamil’in çeperlerinde kentsel ısı adası oluşumu, gözlemlenirken, söz konusu ilçelerin merkezlerinde ise büyük oranda negatif kentsel ısı adası oluşumuna rastlanmıştır. Bu anlamda kent arazi sınıfları ve kentsel ısı adası/negatif kentsel ısı adası oluşumları arasında anlamlı bir bağlantının varlığı tespit edilmiştir.
Kültürü Belgeleme aracı olarak Video Sanatı ve Örnek Bir Uygulama
Authors: Vanlioğlu Mehmet
Published: January 2025

Video sanatı, hareketli görüntüler aracılığıyla kavram, eylem, duygu oluşturan bir sanat formudur. Sanat alanında kavramsal, teknik, kurgu, sergileme amaçlarıyla kullanıldığı gibi arşiv ve toplumsal hafıza kaydı olarak ta kullanılmıştır. Video sanatına Nam June Paik ve Wolf Vostell'in televizyon setleri kullanarak ürettiği ilk enstalasyonların öncülük ettiği söylenebilir. Nam June Paik ve Andy Warhol'un bir Portapak ile filme aldığı ilk videoların tarihi ise 1965’tir. Video, sanatta yeni temsil biçimleri oluşturmaya ve denemeye olanak taşıyan bir araç olmuştur. Bu nedenle video kavramsal bir araç olarak sanatın 1960’lardan sonraki tanımlarında önemli bir rol oynamıştır. Bu çalışmada bir kültüre ait bağlılık içeren ve o kültür ortamında yaşayanlar tarafından bilinen bir cümleden yola çıkılarak bir video sanat çalışması yapılmıştır. Çalışmanın amacı gelişmiş video tekniklerinin sanatta kullanılarak video sanatın bir belgeleme aracı olarak da kullanıldığını vurgulamaktır. Alan yazın taraması yapılmış video sanat ve kültürel bellek tanımlarıyla ilgili veri toplanmıştır. Gazianteplilerce çok bilinen bir söylem olan “Antep’imizin bir tek denizi eksik” cümlesi video sanat gösterimine dönüştürülmüştür. Toplumların sahip oldukları kültürleri onları bir arada tutan ve korunması gereken en önemli değerleridir. Kültürel bellek, belirli bir zamanda oluşmuş ve ortak duygu ve düşüncelerin birikiminden oluşur. Bireysel olarak sahip olunan kültürel bellek kültürün bireysel olarak korunduğu yer olarak ifade edilebilir. Bu bireyselliğin toplumsal bir olguya dönüşmesi ise bireysel kültürel belleklerin canlı tutulması gerekir. Sanat, toplumların ve kültürlerin varlıklarını sürdürmeleri için gerekli olan ortak noktaların hatırlanması ve korunması için önemli yollardan biridir.
Taşlıcalı Yahyâ’nın Divanında Zaman Mefhumu
Authors: Keskin Mehmet
Published: January 2025

Zaman, insanlık tarihi boyunca düşünceyi derinden etkileyen, geçiciliği ve bilinmezliğiyle varoluşsal bir mesele olarak karşımıza çıkar. Felsefeden mitolojiye, doğu ve batı düşünce sistemlerinden İslam tasavvufuna kadar pek çok alanda ele alınan zaman, özellikle edebiyatta farklı yönleriyle işlenmiştir. Divan edebiyatının önemli şairlerinden Taşlıcalı Yahyâ da zaman mefhumunu tasavvufi bir derinlikle ve sanatsal bir incelikle ele alır. Divanında zaman kavramını derinlemesine ele alarak bir yandan dünyevi sınırları işaret ederken, öte yandan bu sınırların ötesinde insanın ilahi gerçekliğe olan bağını simgeler. Yahyâ’nın beyitlerinde zamanın geçiciliği, insanın karşılaştığı güçlükler, aşkın yüceliği ve mistik anlamları gibi birçok tema; ezel, vakit, fenâ, ân, nefes, kadim gibi simgeler aracılığıyla hayat bulur. Yahyâ, zamanın insanı olgunlaştırdığı, çelişkilerle sınadığı ve hakikate yönelttiği temalarını, kendine has üslubuyla işler. Şairin dünyasında zaman, insanın ruhsal yolculuğunda bahar ve hazan gibi mevsim döngüleriyle bütünleşir; bahar yenilenme ve uyanış, hazan ise geçicilik ve dünyevi süslerden arınmanın bir hatırlatıcısı olarak işlenir. Şair, dünün ağırlığını ve acı birikimlerini bugünün ruhuna yansıtırken; "şimdi"yi, sevgiden uzak kalmışlığın yarattığı boşluk ve hayal kırıklığıyla resmeder. Yarın ise onun için umut, vuslat ve adanmışlığın simgesidir. Bu bağlamda Yahyâ’nın divanında zaman, kozmik döngüler, ilahi aşkın sürekliliği ve insana yönelik bir yansıtma gücü olarak karşımıza çıkar. Bu çalışmada, Taşlıcalı Yahyâ divanından hareketle, şairin zaman üzerine getirdiği yorum ve yaklaşımlar incelenmiş; beyitler üzerinden şairin zaman algısı irdelenmiştir. Bu irdeleme sonucunda Taşlıcalı Yahyâ’nın divanında, zaman bir anlatı aracı değil, insanın ruhsal uyanışını ve hakikat arayışını yansıtan derin bir metafor olarak kullandığı görülmüştür. Bu makale, şairin şiirlerindeki zaman mefhumunu ele alarak, Taşlıcalı Yahyâ’nın tasavvufi ve estetik dünyasına ışık tutmayı amaçlamaktadır.
The legal foundations of the Francoist regime
Authors: Manin Iaroslav V. , Burenko Konstantin Andreevich
Published: January 2025

The object of the study is the legal aspect of the Francoist political regime as an element of the form of the state (public relations in the field of governance of Francoist Spain), the subject is regulatory legal acts expressing the existing political system in the state. The authors of the article studied the regime of Francisco Franco and revealed its legislative framework, revealing the legal nature of authoritarianism in a single country, Spain, pointing to the concealment of the authoritarian nature of the dictatorship by democratic laws, as well as the abuse of the right to impose martial law or other emergency forms legalizing the usurpation of power. The relevance of the research topic lies in the possibility of using methods of legislative consolidation of a political structure, as well as substantiating the authoritarian legal nature of specific political regimes, forecasting prospects and modeling the development of dictatorships. The research is relevant for legal theorists and practitioners who substantiate the foundations of the constitutional order of states. The authors considered not the political, but the legal side of the rule of the Spanish speaker, introduced into scientific circulation new information about the norms of Spanish law of the Francoist period of the history of the relevant state. The methodological basis of the research is made of general scientific (comparison, analysis, synthesis, analogy, deduction, induction, and others) and special (formal logical, interpretation of law, and others), historical-legal, systemic, and other methods of cognition. The scientific novelty of the work is due to the analysis of the "Fundamental Laws of the Kingdom." The authors note that the law on succession to the throne provided for the possibility of the usurpation of supreme power in Spain by the Regency Council after the death of Francisco Franco. The purpose of the study is to identify legal methods of consolidating the authoritarian regime. The objectives of the research include the study of the normative legal acts that established the regime of Francisco Franco in Spain, as well as the relevant Russian and foreign doctrine on the topic of the scientific article. The fundamental laws of the Kingdom established the regime of Francisco Franco: a personalistic autocracy, making it stable for the duration of the dictator's life, while at the same time determining its gradual design and transformation in the future. The Francoist regime finally took shape by 1967 with the adoption of the Organic Law of the State, the last of the Fundamental Laws of the Kingdom, which came into force during the lifetime of the authoritarian leader.
Bi-dimensional gravity-influence model: Quantitative assessment of node performance based on individual potential and geographic location
Authors: LIANG ZongWen , LIAO JunZhuo , XUE ChongChen , AO YongCai ,   School of Computer Science and Software Engineering, Southwest Petroleum University, Chengdu 610500, China
Published: January 2025

In complex networks, the accurate assessing of node importance is essential for understanding critical structures and optimizing dynamic processes. Traditional gravity-based methods often rely on local attributes or global shortest paths, which exhibit limitations in heterogeneous networks due to insufficient differentiation of node roles and their influences in different topologies. To address these challenges, we propose the bi-dimensional gravity influence model (BGIM) and its enhanced version (BGIM+). These models introduce a novel entropy-weighted gravity framework that integrates node information entropy, gravity correction factors, and asymmetric attraction factors. By replacing degree centrality with information entropy, BGIM captures nodes’ uncertainty and information richness, offering a more comprehensive view of their potential influence.

The gravity correction factor (NGCF) combines eigenvector centrality with network constraint coefficients to balance global feature and local feature, while the asymmetric attraction factor (AAF) consider gravitational asymmetry between core and peripheral nodes. This bi-dimensional method can evaluate the node importance in more detail and solve the problem of imbalanced influence distribution in different network structures. A normalization mechanism further enhances adaptability, thus ensuring robust performance in both sparse and dense networks.

Extensive experiments on real-world (e.g., Jazz, USAir, Email, Router) and synthetic (LFR-generated) networks validate the proposed models. The results demonstrate that BGIM and BGIM+ consistently outperform classical methods (such as Degree, Closeness, and Betweenness centralities) in identifying critical nodes and predicting their roles in propagation dynamics. In particular, BGIM+ exhibits superior performance in networks with complex topology, achieving high correlation with SIR (Susceptible-Infected-Recovered) model simulations under different propagation rates. Moreover, BGIM+ effectively balances the influences of local hubs and global bridges, thus it is particularly suitable for heterogeneous networks.

This study highlights the significance of incorporating multidimensional features into gravity models for accurate and robust node evaluation. The proposed model advances the development of complex network analysis by providing a universal tool for identifying influential nodes indifferent applications, including epidemic control, information dissemination, and infrastructure resilience. The applicability of BGIM in temporal and dynamic network contexts will be explored in future, so as to further expand its application scope.
Study on the multimodal coupling effect between methylene blue molecular clusters and dual metal nanoparticles
Authors: Zhang Pan  , Fang De-Yin  , Hao Meng-Yuan  , Wang Lu-Xia  ,   Institute of Theoretical Physics, School of Mathematics and Physics, University of Science and; Technology Beijing, Beijing 100083, China
Published: January 2025

Based on the double Rabi splitting experiment in the methylene blue (MB) - silver nanocavity, a structural model of MB molecular clusters and dual metal nanoparticles was established. Using the density matrix theory framework and dipole approximation, the coupling dynamics of the hybrid state formed by MB molecular clusters and dual metal nanoparticles were calculated. The multi-mode coupling effect under the interaction between multi-exciton states and plasmons was studied, and qualitatively consistent results with the experiment were obtained. By short pulse excitation, the coupling states of exciton states and plasmons are studied in a larger excitation frequency domain. The paper explores the effects of exciton decoherence rate and intermolecular distance on the coupling process, as well as the phenomenon that the coupling strength between molecules and plasmons increases with the shortening of exciton decoherence time. Due to the coupling interaction between delocalized excitons and plasmons within the cluster, more hybrid energy levels can be generated in the composite system, resulting in corresponding changes in the optical response peak. By studying the mechanism of multi-mode coupling between molecular clusters and metal nanostructures, theoretical ideas have been provided for designing efficient light harvesting and conversion materials.
Cortico-striatal action control inherent of opponent cognitive-motivational styles
Authors: Avila Cassandra , Sarter Martin
Published: January 2025

Turning on cue or stopping at a red light requires attending to such cues to select action sequences, or suppress action, in accordance with learned cue-associated action rules. Cortico-striatal projections are an essential part of the brain’s attention-motor interface. Glutamate-sensing microelectrode arrays were used to measure glutamate transients in the dorsomedial striatum (DMS) of male and female rats walking a treadmill and executing cued turns and stops. Prelimbic-DMS projections were chemogenetically inhibited to determine their behavioral necessity and the cortico-striatal origin of cue-evoked glutamate transients. Furthermore, we investigated rats exhibiting preferably goal-directed (goal trackers, GTs) versus cue-driven attention (sign trackers, STs), to determine the impact of such cognitive-motivational biases on cortico-striatal control. GTs executed more cued turns and initiated such turns more slowly than STs. During turns, but not missed turns or cued stops, cue-evoked glutamate concentrations were higher in GTs than in STs. In STs, turn cue-locked glutamate concentrations frequently peaked twice or three times, contrasting with predominately single peaks in GTs. In GTs, but not STs, inhibition of prelimbic-DMS projections attenuated turn rates and turn cue-evoked glutamate concentrations and increased the number of turn cue-locked glutamate peaks. These findings indicate that turn cue-evoked glutamate release in GTs is tightly controlled by cortico-striatal neuronal activity. In contrast, in STs, glutamate release from DMS glutamatergic terminals may be regulated by other striatal circuitry, preferably mediating cued suppression of action and reward tracking. As cortico-striatal dysfunction has been hypothesized to contribute to a wide range of disorders, including complex movement control deficits in Parkinson’s disease and compulsive drug taking, the demonstration of phenotypic contrasts in cortico-striatal control implies the presence of individual vulnerabilities for such disorders.
Risk factors affecting polygenic score performance across diverse cohorts
Authors: Hui Daniel , Dudek Scott , Kiryluk Krzysztof , Walunas Theresa L , Kullo Iftikhar J , Wei Wei-Qi , Tiwari Hemant , Peterson Josh F , Chung Wendy K , Davis Brittney H , Khan Atlas , Kottyan Leah C , Limdi Nita A , Feng Qiping , Puckelwartz Megan J , Weng Chunhua , Smith Johanna L , Karlson Elizabeth W ,   Regeneron Genetics Center,   Penn Medicine BioBank, Jarvik Gail P , Ritchie Marylyn D
Published: January 2025

Apart from ancestry, personal or environmental covariates may contribute to differences in polygenic score (PGS) performance. We analyzed the effects of covariate stratification and interaction on body mass index (BMI) PGS (PGSBMI) across four cohorts of European (N = 491,111) and African (N = 21,612) ancestry. Stratifying on binary covariates and quintiles for continuous covariates, 18/62 covariates had significant and replicable R2 differences among strata. Covariates with the largest differences included age, sex, blood lipids, physical activity, and alcohol consumption, with R2 being nearly double between best- and worst-performing quintiles for certain covariates. Twenty-eight covariates had significant PGSBMI–covariate interaction effects, modifying PGSBMI effects by nearly 20% per standard deviation change. We observed overlap between covariates that had significant R2 differences among strata and interaction effects – across all covariates, their main effects on BMI were correlated with their maximum R2 differences and interaction effects (0.56 and 0.58, respectively), suggesting high-PGSBMI individuals have highest R2 and increase in PGS effect. Using quantile regression, we show the effect of PGSBMI increases as BMI itself increases, and that these differences in effects are directly related to differences in R2 when stratifying by different covariates. Given significant and replicable evidence for context-specific PGSBMI performance and effects, we investigated ways to increase model performance taking into account nonlinear effects. Machine learning models (neural networks) increased relative model R2 (mean 23%) across datasets. Finally, creating PGSBMI directly from GxAge genome-wide association studies effects increased relative R2 by 7.8%. These results demonstrate that certain covariates, especially those most associated with BMI, significantly affect both PGSBMI performance and effects across diverse cohorts and ancestries, and we provide avenues to improve model performance that consider these effects.
Respiratory and Cardiac Interoceptive Sensitivity in the First Two Years of Life
Authors: Tünte Markus R , Hoehl Stefanie , Wunderwald Moritz , Bullinger Johannes , Boyadziheva Asena , Maister Lara , Elsner Birgit , Tsakiris Manos , Kayhan Ezgi
Published: January 2025

Several recent theoretical accounts have posited that interoception, the perception of internal bodily signals, plays a vital role in early human development. Yet, empirical evidence of cardiac interoceptive sensitivity in infants to date has been mixed. Furthermore, existing evidence does not go beyond the perception of cardiac signals and focuses only on the age of 5–7 months, limiting the generalizability of the results. Here, we used a modified version of the cardiac interoceptive sensitivity paradigm introduced by Maister et al. (2017) in 3-, 9-, and 18-month-old infants using cross-sectional and longitudinal approaches. Going beyond, we introduce a novel experimental paradigm, namely the iBREATH, to investigate respiratory interoceptive sensitivity in infants. Overall, for cardiac interoceptive sensitivity (
total n
= 135) we find rather stable evidence across ages with infants on average preferring stimuli presented synchronously to their heartbeat. For respiratory interoceptive sensitivity (
total n
= 120) our results show a similar pattern in the first year of life, but not at 18 months. We did not observe a strong relationship between cardiac and respiratory interoceptive sensitivity at 3 and 9 months but found some evidence for a relationship at 18 months. We validated our results using specification curve- and mega analytic approaches. By examining early cardiac and respiratory interoceptive processing, we provide evidence that infants are sensitive to their interoceptive signals.
Cerebellar Purkinje Cells Control Posture in Larval Zebrafish (Danio rerio)
Authors: Auer Franziska , Nardone Katherine , Matsuda Koji , Hibi Masahiko , Schoppik David
Published: January 2025

Cerebellar dysfunction leads to postural instability. Recent work in freely moving rodents has transformed investigations of cerebellar contributions to posture. However, the combined complexity of terrestrial locomotion and the rodent cerebellum motivate new approaches to perturb cerebellar function in simpler vertebrates. Here, we adapted a validated chemogenetic tool (TRPV1/capsaicin) to describe the role of Purkinje cells — the output neurons of the cerebellar cortex — as larval zebrafish swam freely in depth. We achieved both bidirectional control (activation and ablation) of Purkinje cells while performing quantitative high-throughput assessment of posture and locomotion. Activation modified postural control in the pitch (nose-up/nose-down) axis. Similarly, ablations disrupted pitch-axis posture and fin-body coordination responsible for climbs. Postural disruption was more widespread in older larvae, offering a window into emergent roles for the developing cerebellum in the control of posture. Finally, we found that activity in Purkinje cells could individually and collectively encode tilt direction, a key feature of postural control neurons. Our findings delineate an expected role for the cerebellum in postural control and vestibular sensation in larval zebrafish, establishing the validity of TRPV1/capsaicin-mediated perturbations in a simple, genetically-tractable vertebrate. Moreover, by comparing the contributions of Purkinje cell ablations to posture in time, we uncover signatures of emerging cerebellar control of posture across early development. This work takes a major step towards understanding an ancestral role of the cerebellum in regulating postural maturation.
A split-GAL4 driver line resource for Drosophila neuron types
Authors: Meissner Geoffrey W , Vannan Allison , Jeter Jennifer , Close Kari , DePasquale Gina M , Dorman Zachary , Forster Kaitlyn , Beringer Jaye Anne , Gibney Theresa , Hausenfluck Joanna H , He Yisheng , Henderson Kristin , Johnson Lauren , Johnston Rebecca M , Ihrke Gudrun , Iyer Nirmala A , Lazarus Rachel , Lee Kelley , Li Hsing-Hsi , Liaw Hua-Peng , Melton Brian , Miller Scott , Motaher Reeham , Novak Alexandra , Ogundeyi Omotara , Petruncio Alyson , Price Jacquelyn , Protopapas Sophia , Tae Susana , Taylor Jennifer , Vorimo Rebecca , Yarbrough Brianna , Zeng Kevin Xiankun , Zugates Christopher T , Dionne Heather , Angstadt Claire , Ashley Kelly , Cavallaro Amanda , Dang Tam , Gonzalez Guillermo A , Hibbard Karen L , Huang Cuizhen , Kao Jui-Chun , Laverty Todd , Mercer Monti , Perez Brenda , Pitts Scarlett Rose , Ruiz Danielle , Vallanadu Viruthika , Zheng Grace Zhiyu , Goina Cristian , Otsuna Hideo , Rokicki Konrad , Svirskas Robert R , Cheong Han SJ , Dolan Michael-John , Ehrhardt Erica , Feng Kai , Galfi Basel EI , Goldammer Jens , Huston Stephen J , Hu Nan , Ito Masayoshi , McKellar Claire , Minegishi Ryo , Namiki Shigehiro , Nern Aljoscha , Schretter Catherine E , Sterne Gabriella R , Venkatasubramanian Lalanti , Wang Kaiyu , Wolff Tanya , Wu Ming , George Reed , Malkesman Oz , Aso Yoshinori , Card Gwyneth M , Dickson Barry J , Korff Wyatt , Ito Kei , Truman James W , Zlatic Marta , Rubin Gerald M ,   FlyLight Project Team
Published: January 2025

Techniques that enable precise manipulations of subsets of neurons in the fly central nervous system (CNS) have greatly facilitated our understanding of the neural basis of behavior. Split-GAL4 driver lines allow specific targeting of cell types in Drosophila melanogaster and other species. We describe here a collection of 3060 lines targeting a range of cell types in the adult Drosophila CNS and 1373 lines characterized in third-instar larvae. These tools enable functional, transcriptomic, and proteomic studies based on precise anatomical targeting. NeuronBridge and other search tools relate light microscopy images of these split-GAL4 lines to connectomes reconstructed from electron microscopy images. The collections are the result of screening over 77,000 split hemidriver combinations. Previously published and new lines are included, all validated for driver expression and curated for optimal cell-type specificity across diverse cell types. In addition to images and fly stocks for these well-characterized lines, we make available 300,000 new 3D images of other split-GAL4 lines.
A plant-derived biostimulant Aminolom Enzimatico® application stimulates chlorophyll content, electrolyte leakage, stomata density and root yield of radishes under salinity stress
Authors: Kaya Gamze
Published: January 2025

Biostimulants stimulate plant growth and tolerance to salinity stress, which creates unfavorable conditions for plant growth from emergence to harvest; however, little is known about their roles in triggering salt tolerance. Therefore, the study aimed to determine how applying a foliar plant-derived biostimulant (Aminolom Enzimatico® 24%) affects the growth (leaf area, biomass weight, root diameter, root fresh weight, and water-soluble dry matter), physiology (chlorophyll content, electrolyte leakage, cell membrane stability, and relative water content), and stomata of the lower and upper parts of leaves in radish plants (Raphanus sativus L.) under salinity stress. Radish plantlets at 7 d old were irrigated with saline water (i.e., 50, 100, 150, and 200 mM NaCl), and the biostimulant was sprayed twice at 7 d intervals. Under salinity stress, increased water-soluble dry matter content was detected, along with reduced plant biomass weight, root fresh weight, and root diameter. Meanwhile, the foliar biostimulant increased the mean root fresh weight, biomass fresh weight, and leaf area by 12%, 13.6%, and 24% compared to the control, respectively. Increasing NaCl dramatically reduced leaf area and relative water content, whereas chlorophyll content and stomata densities on both sides of the leaves improved. By regulating physiological parameters and thereby promoting root and leaf growth, the biostimulant application improved the radish plants’ tolerance to salinity stress up to 100 mM NaCl. Spraying the biostimulant can also boost plant growth, root yield, and radish quality under moderate salinity stress.
Outcomes of Percutaneous Ultrasound-guided Splenic Procedures: A Retrospective Observational Study from a Tertiary Care Centre in Southern India
Authors: Stephen Ruth Anna , Moses Vinu , Varghese George M , Babu KB Santhosh , Chase Suchita , Keshava Shyamkumar N
Published: January 2025

Introduction: Data on image-guided percutaneous procedures of the spleen are limited, particularly for infectious lesions.

Aim: To evaluate the complication rate of percutaneous ultrasound-guided splenic procedures.

Materials and Methods: A retrospective observational study was conducted in a tertiary care centre in Southern India. Data from all consecutive patients who underwent ultrasound-guided splenic procedures from January 2008 to October 2023 were analysed. Information was extracted from digital radiology reports, images, inpatient records, outpatient records and blood investigation reports. Complications were categorised according to standardised guidelines. Descriptive statistics for categorical data were reported. Pearson Chi-square test were used to assess associations between categorical variables. Statistical Package for the Social Sciences (SPSS) software version 21.0 was used.

Results: A total of 312 patients were included, with mean age of 42.2±15.8 years. Of these, 212 (68%) were males and 100 (32%) were females. There were 259 diagnostic procedures: 125 (40.1%) Fine Needle Aspiration Cytology (FNACs), 18 (5.8%) biopsies and 116 (37.2%) aspirations. Fifty-three procedures were therapeutic: 52 (16.7%) drainages, and 1 (0.3%) percutaneous injection of sclerosant. The overall complication rate was 22 in 312 patients (7.1%, with 95% CI of 4.7% to 10.4%). As per the Society of Interventional Radiology (SIR) Clinical Practice Guidelines classification, six patients (27.3%) had Category-A complications with small perisplenic haematomas, three patients (13.6%) had Category-B complications, 10 patients (45.5%) had Category-C complications and two patients (9.1%) had Category-D complications. One patient (4.5%) died during the postoperative period (Category-F complication). No patients had SIR Category-E complications.

Conclusion: Percutaneous ultrasound-guided procedures were safe and efficacious in this patient cohort, which predominantly consisted of individuals with infectious diseases and exhibited a low mortality rate.