bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from Antitumor Efficacy of Dual Blockade with Encorafenib + Cetuximab in Combination with Chemotherapy in Human BRAFV600E-Mutant Colorectal Cancer
Authors: Napolitano Stefania , Woods Melanie , Lee Hey Min , De Falco Vincenzo , Martini Giulia , Della Corte Carminia Maria , Martinelli Erika , Famiglietti Vincenzo , Ciardiello Davide , Anderson Amanda , Fowlkes Natalie Wall , Villareal Oscar Eduardo , Sorokin Alexey , Kanikarla Preeti , Coker Olu , Morris Van , Altucci Lucia , Tabernero Josep , Troiani Teresa , Ciardiello Fortunato , Kopetz Scott
Published: May 2023

AbstractPurpose:
Encorafenib + cetuximab (E+C) is an effective therapeutic option in chemorefractory BRAFV600E metastatic colorectal cancer (mCRC). However, there is a need to improve the efficacy of this molecular-targeted therapy and evaluate regimens suitable for untreated BRAFV600E in patients with mCRC.
Experimental Design:
We performed a series of in vivo studies using BRAFV600E mCRC tumor xenografts. Mice were randomized to receive 5-fluoruracil (5-FU), irinotecan, or oxaliplatin regimens (FOLFIRI or FOLFOX), (E+C) or the combination. Patients received long-term treatment until disease progression, with deescalation strategies used to mimic maintenance therapy. Transcriptomic changes after progression on cytotoxic chemotherapy or targeted therapy were assessed.
Results:
Antitumor activity of either FOLFIRI or E+C was better as first-line treatment as compared with second-line, with partial cross-resistance seen between a cytotoxic regimen and targeted therapy with an average 62% loss of efficacy for FOLFIRI after E+C and a 45% loss of efficacy of E+C after FOLFIRI (P < 0.001 for both). FOLFIRI-treated models had upregulation of epithelial–mesenchymal transition (EMT) and MAPK pathway activation, where E+C treated models had suppressed MAPK signaling. In contrast, with chemotherapy with E+C, EMT and MAPK signaling remained suppressed. FOLFOX or FOLFIRI, each in combination with E+C, were the most active first-line treatments as compared with E+C or to chemotherapy alone. Furthermore, FOLFOX in combination with E+C as first-line induction therapy, followed by E+C ± 5-FU as maintenance therapy, was the most effective strategy for long-term disease control.
Conclusions:
These results support the combination of cytotoxic chemotherapy and molecular-targeted therapy as a promising therapeutic approach in the first-line treatment of BRAFV600E mCRC.
Data from Adjuvant Nivolumab versus Ipilimumab in Resected Stage III/IV Melanoma: 5-Year Efficacy and Biomarker Results from CheckMate 238
Authors: Larkin James , Del Vecchio Michele , Mandalá Mario , Gogas Helen , Arance Fernandez Ana M. , Dalle Stéphane , Cowey Charles Lance , Schenker Michael , Grob Jean-Jacques , Chiarion-Sileni Vanna , Marquez-Rodas Ivan , Butler Marcus O. , Di Giacomo Anna Maria , Middleton Mark R. , Lutzky Jose , de la Cruz-Merino Luis , Arenberger Petr , Atkinson Victoria , Hill Andrew G. , Fecher Leslie A. , Millward Michael , Nathan Paul D. , Khushalani Nikhil I. , Queirolo Paola , Ritchings Corey , Lobo Maurice , Askelson Margarita , Tang Hao , Dolfi Sonia , Ascierto Paolo A. , Weber Jeffrey
Published: May 2023

AbstractPurpose:
In the phase III CheckMate 238 study, adjuvant nivolumab significantly improved recurrence-free survival (RFS) and distant metastasis-free survival versus ipilimumab in patients with resected stage IIIB–C or stage IV melanoma, with benefit sustained at 4 years. We report updated 5-year efficacy and biomarker findings.
Patients and Methods:
Patients with resected stage IIIB–C/IV melanoma were stratified by stage and baseline programmed death cell ligand 1 (PD-L1) expression and received nivolumab 3 mg/kg every 2 weeks or ipilimumab 10 mg/kg every 3 weeks for four doses and then every 12 weeks, both intravenously for 1 year until disease recurrence, unacceptable toxicity, or withdrawal of consent. The primary endpoint was RFS.
Results:
At a minimum follow-up of 62 months, RFS with nivolumab remained superior to ipilimumab (HR = 0.72; 95% confidence interval, 0.60–0.86; 5-year rates of 50% vs. 39%). Five-year distant metastasis-free survival (DMFS) rates were 58% with nivolumab versus 51% with ipilimumab. Five-year overall survival (OS) rates were 76% with nivolumab and 72% with ipilimumab (75% data maturity: 228 of 302 planned events). Higher levels of tumor mutational burden (TMB), tumor PD-L1, intratumoral CD8+ T cells and IFNγ-associated gene expression signature, and lower levels of peripheral serum C-reactive protein were associated with improved RFS and OS with both nivolumab and ipilimumab, albeit with limited clinically meaningful predictive value.
Conclusions:
Nivolumab is a proven adjuvant treatment for resected melanoma at high risk of recurrence, with sustained, long-term improvement in RFS and DMFS compared with ipilimumab and high OS rates. Identification of additional biomarkers is needed to better predict treatment outcome.
Data from First-in-human study of the radioligand 68Ga-N188 targeting nectin-4 for PET/CT imaging of advanced urothelial carcinoma
Authors: Duan Xiaojiang , Xia Lei , Zhang Zhuochen , Ren Yanan , Pomper Martin G. , Rowe Steven P. , Li Xuesong , Li Nan , Zhang Ning , Zhu Hua , Yang Zhi , Sheng Xinan , Yang Xing
Published: May 2023

Abstract
Purpose: Nectin-4 is an emerging biomarker for cancer diagnosis and therapy. Recently, enfortumab vedotin (EV) was approved by the FDA as the first nectin-4 targeting antibody-drug conjugate for treating advanced urothelial carcinoma. A PET imaging method to non-invasively quantify nectin-4 expression level would potentially help to select patients most likely to respond to EV and predict the response. Experimental Design: In this study, we designed a bicyclic peptide-based nectin-4 targeting radiotracer 68Ga-N188. Initially, we performed preclinical evaluations of 68Ga-N188 in urothelial cancer cell lines and xenograft mouse models. Next, we performed the translational study in healthy volunteers and a pilot cohort of patients with advanced urothelial cancer on uEXPLORER total-body PET/CT. Results: In the preclinical study, 68Ga-N188 showed high affinity to nectin-4, specific uptake in a nectin-4(+) xenograft mouse model, suitable pharmacokinetic and safety profiles. In the translational study, two healthy volunteers and fourteen patients with advanced urothelial cancer were enrolled in the translational study. The pharmacokinetic profile was determined for 68Ga-N188, and the nectin-4 relative expression level in different organs was quantitatively imaged. Conclusions: A clear correlation between PET SUV value and nectin-4 expression was observed, supporting the application of 68Ga-N188 PET as a companion diagnostic tool for optimizing treatments that target nectin-4.
Data from PI3K Inhibition Restores and Amplifies Response to Ruxolitinib in Patients with Myelofibrosis
Authors: Moyo Tamara K. , Kishtagari Ashwin , Villaume Matthew T. , McMahon Brandon , Mohan Sanjay R. , Stopczynski Tess , Chen Sheau-Chiann , Fan Run , Huo Yuankai , Moon Hyeonsoo , Tang Yucheng , Bejan Cosmin A. , Childress Merrida , Anderson Ingrid , Rawling Kyle , Simons Rhea M. , Moncrief Ashley , Caza Rebekah , Dugger Laura , Collins Aunshka , Dudley Channing V. , Ferrell P. Brent , Byrne Michael , Strickland Stephen A. , Ayers Gregory D. , Landman Bennett A. , Mason Emily F. , Mesa Ruben A. , Palmer Jeanne M. , Michaelis Laura C. , Savona Michael R.
Published: May 2023

AbstractPurpose:
Treatment options are limited beyond JAK inhibitors for patients with primary myelofibrosis (MF) or secondary MF. Preclinical studies have revealed that PI3Kδ inhibition cooperates with ruxolitinib, a JAK1/2 inhibitor, to reduce proliferation and induce apoptosis of JAK2V617F-mutant cell lines.
Patients and Methods:
In a phase I dose-escalation and -expansion study, we evaluated the safety and efficacy of a selective PI3Kδ inhibitor, umbralisib, in combination with ruxolitinib in patients with MF who had a suboptimal response or lost response to ruxolitinib. Enrolled subjects were required to be on a stable dose of ruxolitinib for ≥8 weeks and continue that MTD at study enrollment. The recommended dose of umbralisib in combination with ruxolitinib was determined using a modified 3+3 dose-escalation design. Safety, pharmacokinetics, and efficacy outcomes were evaluated, and spleen size was measured with a novel automated digital atlas.
Results:
Thirty-seven patients with MF (median age, 67 years) with prior exposure to ruxolitinib were enrolled. A total of 2 patients treated with 800 mg umbralisib experienced reversible grade 3 asymptomatic pancreatic enzyme elevation, but no dose-limiting toxicities were seen at lower umbralisib doses. Two patients (5%) achieved a durable complete response, and 12 patients (32%) met the International Working Group-Myeloproliferative Neoplasms Research and Treatment response criteria of clinical improvement. With a median follow-up of 50.3 months for censored patients, overall survival was greater than 70% after 3 years of follow-up.
Conclusions:
Adding umbralisib to ruxolitinib in patients was well tolerated and may resensitize patients with MF to ruxolitinib without unacceptable rates of adverse events seen with earlier generation PI3Kδ inhibitors. Randomized trials testing umbralisib in the treatment of MF should be pursued.
Supplementary Figure Legends 1-7 from Dynamic Intestinal Stem Cell Plasticity and Lineage Remodeling by a Nutritional Environment Relevant to Human Risk for Tumorigenesis
Authors: Choi Jiahn , Zhang Xusheng , Li Wenge , Houston Michele , Peregrina Karina , Dubin Robert , Ye Kenny , Augenlicht Leonard
Published: May 2023

S1. The western diet extensively reprograms Lgr5hi stem cells that expands with time and is reversible. This includes the TCA cycle and Oxphos pathways.S2. The western diet elevates and suppresses multiple pathways by 3 months, most persisting to 12 months, and reversible by switching to control diet.S3. The western diet suppresses expression of a large number of genes encoding subunits of each of the 5 complexes of mitochondrial electron transport.S4. Mouse genotyping identified presence of the wild-type, or heterozygous or homozygous conditionally targeted Ppargc1a allele.S5. Rapid dietary cross-over experiment of Fig 3.S6. scRNAseq analysis of Bmi1+ derived cells.S7. Inflammatory response to NWD1.
Figure S4 from Dynamic Intestinal Stem Cell Plasticity and Lineage Remodeling by a Nutritional Environment Relevant to Human Risk for Tumorigenesis
Authors: Choi Jiahn , Zhang Xusheng , Li Wenge , Houston Michele , Peregrina Karina , Dubin Robert , Ye Kenny , Augenlicht Leonard
Published: May 2023

Targeted knockout of Ppargc1a in Lgr5hi cells was confirmed, and trajectory analyses of dietary and genetic alterations confirmed by marker expression.
Figure S1 from Dynamic Intestinal Stem Cell Plasticity and Lineage Remodeling by a Nutritional Environment Relevant to Human Risk for Tumorigenesis
Authors: Choi Jiahn , Zhang Xusheng , Li Wenge , Houston Michele , Peregrina Karina , Dubin Robert , Ye Kenny , Augenlicht Leonard
Published: May 2023

The western diet extensively reprograms Lgr5hi stem cells that expands with time and is reversible. This includes the TCA cycle and Oxphos pathways
Supplementary Figure 2 from Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma
Authors: Shah Payal D. , Huang Alexander C. , Xu Xiaowei , Orlowski Robert , Amaravadi Ravi K. , Schuchter Lynn M. , Zhang Paul , Tchou Julia , Matlawski Tina , Cervini Amanda , Shea Joanne , Gilmore Joan , Lledo Lester , Dengel Karen , Marshall Amy , Wherry E. John , Linette Gerald P. , Brennan Andrea , Gonzalez Vanessa , Kulikovskaya Irina , Lacey Simon F. , Plesa Gabriela , June Carl H. , Vonderheide Robert H. , Mitchell Tara C.
Published: May 2023

Supplementary Figure 2: Representative immunohistochemical staining for Subject 27 with metastatic triple-negative breast cancer; lymph node biopsy. Panel A shows CD8 staining prior to infusion and Panel B shows CD8 staining at the time of post-infusion biopsy.
FIGURE 4 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas
Authors: Sertier Anne-Sophie , Ferrari Anthony , Pommier Roxane M. , Treilleux Isabelle , Boyault Sandrine , Devouassoux-Shisheboran Mojgan , Kielbassa Janice , Thomas Emilie , Tonon Laurie , Le Texier Vincent , Charreton Amandine , Morel Anne-Pierre , Floquet Anne , Joly Florence , Berton-Rigaud Dominique , Ferron Gwenaël , Arnould Laurent , Croce Sabrina , Bataillon Guillaume , Saintigny Pierre , Mery-Lamarche Eliane , Sagan Christine , Senaratne Aruni P. , Gut Ivo G. , Calvo Fabien , Viari Alain , Ouzounova Maria , Ray-Coquard Isabelle , Puisieux Alain
Published: May 2023

Evolutionary histories of CS. Clonal lineage histories of P02 MSI phenotype tumor (A), P12 BRCAness-phenotype tumor (B), and P15 ovarian bilateral tumor (C). Left, Clonal lineage inference for the whole tumor: subclonal populations (Ci), main cancer gene alterations, genome doubling events, and representative mutational signature proportions are represented. Right, Subclonal population frequencies projection in each tumor sample. Clones colored in gray are found in both derived samples, pink (or green) clones are specific to sarcoma- (or carcinoma-) derived samples, respectively.
Figure S3 from A novel class of Ribosome Modulating Agents (RMAs) exploits cancer ribosome heterogeneity to selectively target the CMS2 subtype of colorectal cancer
Authors: Terzo Esteban , Apte Shruti A , Padhye Simran , Rashed Saleh , Austin Wesley , Caponegro Michael , Reddy Anupama , Shi Shuhao , Wang Christy , Clark Roger B , Sidransky David , Modur Vijay , Badarinarayana Vasudeo
Published: May 2023

FACS analysis demonstrating ZKN-157 selectively induces cell cycle arrest and apoptosis
Data from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas
Authors: Sertier Anne-Sophie , Ferrari Anthony , Pommier Roxane M. , Treilleux Isabelle , Boyault Sandrine , Devouassoux-Shisheboran Mojgan , Kielbassa Janice , Thomas Emilie , Tonon Laurie , Le Texier Vincent , Charreton Amandine , Morel Anne-Pierre , Floquet Anne , Joly Florence , Berton-Rigaud Dominique , Ferron Gwenaël , Arnould Laurent , Croce Sabrina , Bataillon Guillaume , Saintigny Pierre , Mery-Lamarche Eliane , Sagan Christine , Senaratne Aruni P. , Gut Ivo G. , Calvo Fabien , Viari Alain , Ouzounova Maria , Ray-Coquard Isabelle , Puisieux Alain
Published: May 2023

Gynecologic carcinosarcomas (CS) are biphasic neoplasms composed of carcinomatous (C) and sarcomatous (S) malignant components. Because of their rarity and histologic complexity, genetic and functional studies on CS are scarce and the mechanisms of initiation and development remain largely unknown.

Whole-genome analysis of the C and S components reveals shared genomic alterations, thus emphasizing the clonal evolution of CS. Reconstructions of the evolutionary history of each tumor further reveal that C and S samples are composed of both ancestral cell populations and component-specific subclones, supporting a common origin followed by distinct evolutionary trajectories. However, while we do not find any recurrent genomic features associated with phenotypic divergence, transcriptomic and methylome analyses identify a common mechanism across the cohort, the epithelial-to-mesenchymal transition (EMT), suggesting a role for nongenetic factors in inflicting changes to cellular fate. Altogether, these data accredit the hypothesis that CS tumors are driven by both clonal evolution and transcriptomic reprogramming, essential for susceptibility to transdifferentiation upon encountering environmental cues, thus linking CS heterogeneity to genetic, transcriptomic, and epigenetic influences.
Significance:
We have provided a detailed characterization of the genomic landscape of CS and identified EMT as a common mechanism associated with phenotypic divergence, linking CS heterogeneity to genetic, transcriptomic, and epigenetic influences.
Data from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Authors: Terzo Esteban , Apte Shruti A. , Padhye Simran , Rashed Saleh , Austin Wesley , Caponegro Michael , Reddy Anupama , Shi Shuhao , Wang Christy , Clark Roger B. , Sidransky David , Modur Vijay , Badarinarayana Vasudeo
Published: May 2023

Ribosomes in cancer cells accumulate numerous patient-specific structural and functional modifications that facilitate tumor progression by modifying protein translation. We have taken a unique synthetic chemistry approach to generate novel macrolides, Ribosome modulating agents (RMA), that are proposed to act distal to catalytic sites and exploit cancer ribosome heterogeneity. The RMA ZKN-157 shows two levels of selectivity: (i) selective translation inhibition of a subset of proteins enriched for components of the ribosome and protein translation machinery that are upregulated by MYC; and (ii) selective inhibition of proliferation of a subset of colorectal cancer cell lines. Mechanistically, the selective ribosome targeting in sensitive cells triggered cell-cycle arrest and apoptosis. Consequently, in colorectal cancer, sensitivity to ZKN-157 in cell lines and patient-derived organoids was restricted to the consensus molecular subtype 2 (CMS2) subtype that is distinguished by high MYC and WNT pathway activity. ZKN-157 showed efficacy as single agent and, the potency and efficacy of ZKN-157 synergized with clinically approved DNA-intercalating agents which have previously been shown to inhibit ribogenesis as well. ZKN-157 thus represents a new class of ribosome modulators that display cancer selectivity through specific ribosome inhibition in the CMS2 subtype of colorectal cancer potentially targeting MYC-driven addiction to high protein translation.
Significance:
This study demonstrates that ribosome heterogeneity in cancer can be exploited to develop selective ribogenesis inhibitors. The colorectal cancer CMS2 subtype, with a high unmet need for therapeutics, shows vulnerability to our novel selective ribosome modulator. The mechanism suggests that other cancer subtypes with high MYC activation could also be targeted.
Dois extremos da atuação das CAPs e IAPs no campo habitacional de Passo Fundo, RS: CAPFESP e IAPB
Authors: Souza Edgar de
Published: May 2023

As Caixas e os Institutos de Aposentadoria e Pensões (1930-1964) tiveram protagonismo nas discussões e na materialização das reflexões acerca da construção do espaço urbano e habitacional do século XX. Contudo, sem uniformidade regulamentar, a atuação das CAPs e IAPs resultou em diferenças na qualidade, nos serviços e no volume de benefícios ofertados por cada instituição. Desta forma, no presente artigo, objetiva-se analisar o projeto arquitetônico de duas distintas habitações financiadas na cidade de Passo Fundo/RS, pela CAPFESP e IAPB. Metodologicamente, o estudo foi dividido em revisão bibliográfica, análise documental e análise gráfica. O trabalho é justificado essencialmente pela escassez de estudos que analisem arquitetonicamente as ações de tais instituições, sobretudo em cidades médias distantes do eixo Rio-São Paulo.
O posto e seu oposto: reflexões sobre a morfose tecnológica de um novo arranjo produtivo
Authors: Ferreira Thiago Lopes , Lopes João Marcos de Almeida
Published: May 2023

Partindo de uma abordagem analítica acerca das características que conformam o atual modelo produtivo e seus arranjos na cadeia da construção civil, o artigo propõe um conjunto de reflexões teóricas quanto às possibilidades de recomposição produtiva, apontando para um novo arranjo pautado por distintas relações de produção dos materiais de construção e outras perspectivas sociotécnicas de aplicação. A morfose tecnológica de uma nova matriz produtiva configura-se como condição impreterível diante dos colapsos ambientais e das crises sociais factuais. Nesta orientação, a reinserção dos materiais naturais, de baixo impacto ambiental, como disparadores de novos arranjos produtivos, potencializa a reapropriação dos produtores da fabricação dos materiais e componentes construtivos, expandindo suas condições de autonomia produtiva, portadora de princípios educativos, criativos e emancipatórios.
O plano nº 12: uma leitura sobre o plano do grupo STAM para a Nova Capital Federal do Brasil
Authors: Quintanilha Rogério Penna
Published: May 2023

O artigo, financiado pela FAPESP, procura apresentar e interpretar o plano apresentado pelo grupo STAM, formado por Joaquim Guedes, Liliana Guedes, Domingos de Azevedo e Carlos Milan, participante do concurso nacional para o plano piloto da nova capital federal do Brasil, realizado em 1957. Apesar de não classificado, o plano despertou certo interesse ao longo das décadas a despeito da ausência de seu memorial, peça importante para a correta compreensão de seu contexto e intenções, que estava perdido e foi localizado apenas em 2016 O artigo é dividido em 3 partes, localizando o plano do grupo STAM em relação aos demais participantes do concurso, tratando do registro do plano e finalmente enumerando e os pontos fundamentais para sua compreensão.
Ex-incentros: teoria, construções e problemas
Authors:   Universidade de São Paulo. Faculdade de Zootecnia e Engenharia de Alimentos, Linhares Juan López
Published: May 2023

Todo triângulo permite a construção de um incírculo e três ex-incírculos. Os centros destes são chamados de incentro e ex-incentros. Seu estudo está diretamente relacionado com as bissetrizes internas e externas. Muitos problemas olímpicos exploram geometrias que utilizam esses elementos. A discussão neste e-book é organizada em quatro capítulos: Fundamentos teóricos; Construções, exercícios e desafios; Teorema de Feuerbach; Problemas de olimpíadas internacionais. Este material didático foi utilizado durante algumas das aulas do curso ``Geometria Olímpica com GeoGebra'' para professores de Matemática do Ensino Fundamental e Médio de todo o Brasil. O texto conta com 50 figuras que facilitam acompanhar a resolução. Todas têm como complemento links para os gráficos interativos no site do GeoGebra e, vários, a resolução em vídeo do YouTube. O diferencial na utilização do GeoGebra está baseado na disponibilidade gratuita do software, tanto online como aplicativos para computadores e celulares. As construções geométricas podem ser feitas de forma dinâmica, onde exploram-se diversas configurações de um mesmo problema. O GeoGebra serve tanto como calculadora gráfica e numérica, utilizada para a verificação, como ferramenta para a apresentação, passo a passo, de uma demonstração rigorosa. O GeoGebra também convida o leitor a interagir, a pôr as mão na massa.
A ciência do jornalismo (& muito mais) volume 2
Authors:   Universidade de São Paulo. Escola de Comunicações e Artes
Published: May 2023

Este livro é fruto dos encontros da disciplina A Ciência do Jornalismo, que foi oferecida no segundo semestre de 2022 no Programa de Pós-Graduação em Ciências da Comunicações da Escola de Comunicações e Artes da Universidade de São Paulo. Os temas abordados pelos docentes, alunos e colaboradores recuperam o conteúdo discutido e analisado durante as aulas. Os artigos e ensaios trabalham questões relacionadas ao universo do jornalismo e suas vertentes. Este livro é o segundo volume da Série Alterjor – Grupo de Pesquisa em Jornalismo Popular e Alternativo da ECA-USP.
Intersecções entre sexo e horror em dois contos de João do Rio
Authors: Fraccari Sabrina Ferraz , Santos Pedro Brum
Published: May 2023

Este artigo objetiva analisar elementos que sugerem uma insinuação sexual/pornográfica nos contos “O bebê de tarlatana rosa” e “O carro da Semana Santa”, publicados em Dentro da noite, de João do Rio (1881-1921). O escritor carioca incorpora elementos populares dos chamados “livros para homens” (eufemismo para livros pornográficos) a fim de promover um jogo com as expectativas dos leitores, insinuando encontros sexuais que, entretanto, caminham para o horror. A intersecção entre sexo e horror pode ser lida como influência direta do Decadentismo, estética que reverbera na produção literária de João do Rio.
Mulheres de bigode: masculinidades, gênero e a Guerra da Tríplice Aliança na ficção de Joaquim Manuel de Macedo
Authors: Braga-Pinto César
Published: May 2023

Narrativas históricas revelam casos de mulheres, como Jovita Alves Feitosa, que se vestiram como homens para combater na Guerra da Tríplice Aliança. Menos conhecidos, porém, são os casos de homens que teriam se travestido para fugir ao recrutamento obrigatório. Este artigo propõe que o romance Mulheres de mantilha (1870), de Joaquim Manuel de Macedo, representa o desejo de novas performances de masculinidade. Discordando daqueles que leram o romance como um dos primeiros exemplos de homoerotismo feminino, este trabalho sugere que, ao introduzir a figura da filha virtuosa atraída por outra mulher (na verdade, um homem travestido), Macedo renova as noções de honra masculina e virtude feminina.
Livro de uma sogra (1895), de Aluísio Azevedo (ou “como conservar o amor sexual”)
Authors: Mendes Leonardo , Santos Marina Pozes Pereira dos
Published: May 2023

Nesse trabalho, propomos estudar o Livro de uma sogra (1895), de Aluísio Azevedo, como um produto cultural comercialmente bem-sucedido. Para compreender o sucesso do livro, o situamos no contexto da expansão editorial do fim do século e do aparecimento dos “manuais práticos”. A obra se comunicava com o “sogrismo”, uma antiga tradição satírica que maldizia as sogras. Valia-se de apimentadas estratégias libertinas, como a narradora feminina ilustrada, e tinha como missão ensinar aos leitores como manter viva a chama sexual no casamento. Nessa visada, o Livro de uma sogra emerge como uma obra erótica, popular e cômica, que marcou a vida cultural da Belle Époque.
Putos e fanchonos na Belle Époque carioca: representações da homossexualidade masculina em três contos pornográficos (1914-1916)
Authors: Cardoso Erika
Published: May 2023

Este artigo propõe uma breve reflexão sobre as representações da homossexualidade masculina presentes nos contos O Menino do Gouveia, Na Zona... e O Cachorro, publicados pelo jornal carioca O Rio Nu, entre 1914 e 1916, como parte da Coleção Contos Rápidos. A ideia é analisar como os personagens masculinos que se relacionavam sexualmente com outros homens figuravam nessas narrativas, que estereótipos eles encarnavam e de que forma essas narrativas se relacionavam com o cotidiano da cidade.
A imoralidade do orgasmo feminino em A história de cada uma: os serões do convento
Authors: Menezes Maria Isabela Berenguer de , Azevedo Natanael Duarte de
Published: May 2023

A breve discussão que se sucede pretende analisar a representação do gozo feminino através dos conceitos psicanalíticos de Imaginário, Real e Simbólico, aplicados ao corpus do romance ficcional A história de cada uma: Os serões do convento (sd), de Rabelais, pseudônimo atribuído a Alfredo Gallis. A análise do romance pornográfico se insere numa perspectiva historiográfica da literatura brasileira, tendo como recorte o período finissecular de Oitocentos, considerado um marco temporal na circulação de obras licenciosas, para serem lidas com uma única mão, e no protagonismo da sexualidade no campo literário-psicanalítico.
Livros que as mulheres (não) devem ler: impressos licenciosos no Brasil no final do Oitocentos
Authors: Moreira Aline
Published: May 2023

Extremamente populares entre os leitores das principais cidades do país, os livros licenciosos eram uma preocupação constante entre a sociedade conservadora. Sem poder contar com a lei para reprimir e exterminar definitivamente o consumo de pornografia, clamava-se às autoridades políticas que agissem em favor do pudor público. A popularidade do gênero é revelada sobretudo pelos anúncios das livrarias e pelas críticas preocupadas quanto ao efeito pernicioso desses livros. Anônimos ou não, os impressos forneciam um arsenal farto de informações sobre sexo que poderiam ser aprendidas por moças e mulheres de família. Era uma literatura perigosamente pedagógica: ensinava como sentir prazer, estando uma mulher só ou acompanhada. Mostrava mulheres vivendo de maneira autônoma, sem punições ou consequências. Neste artigo, vamos conhecer dois desses livros: o anônimo Amar, gozar, morrer (c.1878) e Cocotes e conselheiros (1887), do pseudônimo Rabelais. Percorrendo as fontes primárias e comentando estes e outros livros, buscamos ampliar o nosso conhecimento sobre a literatura – e as leitoras – do período.
Hobbesian Diffidence, Second-Order Discrimination, and Racial Profiling
Authors: Wilson Yolonda Y.
Published: May 2023

Taking Hobbesian logic as my starting point, I argue that Hobbesian diffidence, one of the causes of quarrel in the state of nature, does not disappear once the citizens enter civil society. Rather, diffidence is merely contained by the sovereign. Following Alice Ristroph, I argue that diffidence comes to shape what citizens demand of the state/sovereign in the criminal law. However, I show that Ristroph does not fully appreciate that the concept of diffidence is a racialized one, and as such, race underlies how the citizens understand their own diffidence, what citizens demand of the sovereign, and how they demand it. Further, because diffidence itself is racialized, criminal law need not make explicit appeals to race. Once racialized diffidence becomes embedded in the criminal law, it remains there regardless of any conscious racial animus. I show that racial profiling is a prime example of how this racialized diffidence manifests. Thus, I present Hobbesian diffidence as a framework from which to understand racial oppression. This paper is primarily an application of Hobbes to contemporary issues rather than an exegesis and analysis of Hobbes’s views.
The Ethical Turn of Neo-Traditionalism: Karāmāt al-awliyāʾ in Nuh Keller’s Sea Without Shore
Authors: Kulieva Elvira
Published: May 2023

This article focuses on the concept of karāmāt al-awliyāʾ in the contemporary Sufi manual Sea Without Shore by Nuh Ha Mim Keller (b. 1954), an American convert and a major representative of the neo-traditionalist camp. Through situating Sea Without Shore within the context of early Sufi manuals, this article analyses the specificities of Keller’s interpretation of karāmāt al-awliyāʾ. I argue that his approach represents an ethical turn, as his discussion aims to lessen anxiety about the metaphysical aspects of miracles and instead direct attention towards the ethical standards that make the awliyāʾ extraordinary. By emphasizing the ethical over the metaphysical, Keller’s handling of the subject of karāmāt al-awliyāʾ does not challenge modern “rational” sensitivities, but instead re-frames the idea of miracles for the modern age. In the wider context, this article contributes to a more nuanced understanding of the ways that neo-traditionalists are interpreting and adapting Muslim traditions to modernity.
The Notion of Mistake in Blockchain-Based Smart Contracts: An Analysis of B2C2 Ltd v Quoine Pte Ltd from a Comparative Perspective
Authors: Cassar Damian P.
Published: May 2023

The paper draws a comparative analysis on the doctrine of mistake in contract law between common law and civil law traditions, to explore the legal implications and ramifications of blockchain technology, as one form of dlt, and smart contracting. The case of B2C2 Ltd v. Quoine Pte Ltd is instrumental in portraying how an actual legal dispute may arise in smart contracting relationships, whereby little to no human intervention exists. By comparatively analysing the two legal systems, one may understand better the judgments delivered by the courts in Singapore, the historical common law background leading to such a decision as confirmed also in appellate stage, the consequences such a decision may possibly have on the adoption of similar smart contracting arrangements, and the possible approach under a civil law regime. The conclusions pinpoint some crucial observations relating to the legal approach courts may adopt and their consequences on such contracting arrangements.
Jesuits and Print: the Polemical Example of John Hay
Authors: Lamal Nina , Machielsen Jan
Published: May 2023

This introductory article employs the Scottish Jesuit John Hay as a starting point for a wider exploration of the relationship between Jesuits and print, the theme of this special issue. Hay demonstrates how important print could be to a Jesuit’s self-worth and identity. In this, as contemporary catalogs of Jesuit publications attest, he was not alone, but he was a controversial outlier. Hay’s superiors prevented him from continuing a vociferous polemical exchange and appeared to guide him towards a more suitable subject: translations of missionary reports. Hay’s career in print points to the importance of geography and context in shaping Jesuit publications, and to the conflicts between individual authorial projects and institutional restraints. His example shows above all that the commonplace equation of Jesuits with print requires urgent historical investigation. The essays presented here seek to remedy this oversight by paying attention to Jesuits as authors, printers, and readers.
Jesuit Attitudes Toward Printers and Printing in Early Modern Italy
Authors: Mancini Lorenzo
Published: May 2023

The Society of Jesus engaged with the medium of print almost from its inception and, as in other fields, according to its own way of proceeding. This article studies two aspects of Jesuit engagement with print, using its Italian assistancy as a case study. In the first part, Jesuit attitudes towards printing technology—its dangers and opportunities—are examined, focusing especially on the relationship between Robert Bellarmine and some of his printers. What emerges is an overriding concern for accuracy: the need to disseminate texts without typographical errors in order to avoid misinterpretations and possible accusations of heresy. The second part of the article analyzes one possible solution to this difficulty: Jesuit attempts, at the Roman College and elsewhere, at managing their own printing presses. As these efforts regularly ended in economic failure, they bring into question the traditional view of Jesuits as skilled administrators.
Frantz Fanon as Witness and Participant: Theorising a Peasant Revolution
Authors: Moussa Mohammed
Published: May 2023

Frantz Fanon was not only a witness to colonial violence and its equally violent anti-colonial response, he was also a participant who contributed to the fln’s campaign for liberation from the French metropole. Thus, the twin roles of witness and participant in the Algerian anti-colonial struggle allowed Fanon to theorise revolution away from the putative detachment of the ivory towers of academic speculation or distant commentators. This paper’s meditation on Fanon and his theorising of the anti-colonial struggle as a peasant revolution is divided into two sections. I will first sketch out the background of colonial Algeria and the nature of anti-colonial liberation in the Third World in the middle of the twentieth century. The second section will discuss Fanon’s conception of revolution in which the peasantry, alongside the “illegalist militants,” initiate a wave of mobilisation that begins in the countryside and embraces the colonised centre of the towns.
Types of some Mexican names in Amaranthaceae s.l. (Caryophyllales)
Authors: SANDOVAL-ORTEGA MANUEL HIGINIO , ZUMAYA-MENDOZA SILVIA
Published: May 2023

The family Amaranthaceae has a cosmopolitan distribution and it is one of the most diverse families within the order Caryophyllales. Species of Amaranthaceae live mainly in arid environments, saline habitats, or disturbed areas. Nomenclature is the necessary first-step to study the members of this group, aiming to clarify their identity which is often critical. The types of four names in Amaranthaceae (sensu lato, including Chenopodiaceae)—Chenopodium berlandieri, Celosia monosperma, Iresine grandis var. glabrata, Iresine interrupta—with Mexican loci classici are designated in the present paper, including comments on their identities.
Knockdown of Long Non-Coding RNA (LncRNA) MAFG Divergent Transcript Inhibits the Tumorigenesis of Hepatocellular Carcinoma Through miR-339-5p/CDC25A Axis
Authors: Shi Yongguo , Guo Jianxiong , Ye Aiqin , Zhou Juan , Zheng Lei , Cai Jian
Published: May 2023

Hepatocellular carcinoma (HCC) is frequently diagnosed at late stages when curative treatments are no more applicable. Hence, it is essential to explore new strategie sagainst HCC. Long non-coding RNA (LncRNA) MAFG divergent transcript (MAFG-DT) was known to act as a modulator in various
cancers. Nevertheless, the role of MAFG-DT in HCC remains unexplored. The Cancer Genome Atlas (TCGA) and bioinformatics analyzes were used to explore MAFG-DT level in HCC. In addition, LncBase was used to explore the downstream miRNA of MAFG-DT, and target scan was applied to analyze the targets
of miR-339-5p. Meanwhile, bioinformatics tool was applied to assess the role of CDC25A and miR-339-5p in HCC. Furthermore, CCK8 and transwell assays were applied to assess the cell viability and migration. MAFG-DT level was elevated in HCC tissues. MAFG-DT level was positively correlated with
the advanced TNM stage, vascular invasion, histologic grade recurrence and mortality. Kaplan–Meier analysis suggested that MAFG-DT was negatively associated with recurrence-free survival (RFS) and overall survival in HCC. Meanwhile, MAFG-DT was verified to sponge miR-339-5p, and CDC25A
was the target mRNA of miR-339-5p. MAFG-DT silencing could significantly inhibit the viability of migration of HCC cells through binding to miR-339-5p. MAFG-DT silencing inhibited the development of HCC through miR-339-5p/CDC25A axis. Thus, our study might supply a new target against HCC.
Spinal Cord Injury Repair in a Rat Model via a Sophisticated Delivery System Composed of Schwan Cells, Calcium Alginate Hydrogel, and Bellis perennis Extract-Loaded Gelatin Nanofibers
Authors: Li Huanan , Han Bao , Chen Zhihao , Shen Zhaoliang
Published: May 2023

In the current study, a potential treatment modality for spinal cord injury repair was developed. The delivery system was prepared by crushing the Bellis perennis extract-loaded gelatin nanofibers and loading them into calcium alginate hydrogels. The properties of this delivery
system including its microarchitecture, biocompatibility, biodegradation, and hemocompatibility were studied in vitro. Then, the healing potential of this system co-administrated with Schwan cells was investigated in a rat model of spinal cord injury. Results showed that co-delivery
of Schwan cells and Bellis perennis extract had the highest rate of motor function recovery. Gene expression studies showed that the co-delivery system augmented the tissue expression levels of basic fibroblast growth factor and brain derived neurotrophic factor genes.
Co-Delivery of Curcumin and Resveratrol via a Hydrogel/Nanoparticle System Modulate NF-kB Inflammatory Signalling Pathway in Rat Model of Traumatic Spinal Cord Injury
Authors: Liu Xiajun , Ma Wenbin , Song Defu , Rohani Saeed
Published: May 2023

In this research, a nanocomposite delivery system was developed for the delivery of curcumin and resveratrol to treat spinal cord injury in rat model. The nanoparticles were prepared using the ionotropic gelation method and then dispersed in a calcium alginate hydrogel. The delivery
system was characterized in vitro and its healing potential was evaluated in a rat model of spinal cord injury. Study showed that the nanocomposite system was not toxic against PC-12 cells and showed a sustained release profile for both drugs. In vivo study showed that co-administration
of curcumin and resveratrol had significantly higher healing activity compared with the animals treated with other groups. In addition, the delivery system downregulated the expression profile of NF-kB and TNF-a genes.
Construction and Validation of A Novel Predictive Model Based on Chromatin Regulators in Endometrial Cancer
Authors: Zhao Ling , Peng Chuyu , Wang Haolun , Ou Shanshan , Li Ting , Wei Peiru , Zhu Jianbin , Liu Bo
Published: May 2023

Chromatin regulators (CRs) are substantially associated with the prognosis and immunotherapy responses in multiple cancers. However, comprehensive studies related to the prognostic prediction of CRs in endometrial cancer (UCEC) still remains lacking. Therefore, first, we constructed a prognostic model for UCEC associated with 23 CRs using a univariate Cox regression model as well as the glmnet R package. Then, based on the median risk scores, we separated the UCEC sufferers into the high risk set and low risk set, in which the proportion of sufferers with pathological grade G3 and clinical-stage III–IV is higher in the high risk one. Furthermore, we investigated the association of independent prognostic factors, immunotherapy-related scores, GO, KEGG pathways, and drug sensitivity between both groupings. We identified the high risk set tended to have lower IPS, microsatellite instability, and tumor mutational load. GO and KEGG suggested an enrichment of genes related to ribosome biogenesis, RNA processing and metabolism, viral defence, translational regulation, and calmodulin-binding in the high-risk one, while the other one related to cilia movement, microtubule movement, axonal components, and calmodulin-binding. Drug sensitivity assay showed sensitive doxorubicin could be applied to the high-risk patients. All in all, our team successfully built and validated a predictive model for CRs that predicts the overall survival of UCEC patients, which may provide a potential new direction for prognosis prediction and therapeutic target selection for UCEC patients.
Application of Self-Adaptive Medical Ultrasonic Imaging Algorithm-Based Obturator Nerve Block in Transurethral Resection of Bladder Tumor
Authors: Sun Haoliang
Published: May 2023

The application values of ultrasound-guided obturator nerve block (ONB) optimized by self-adaptive algorithm in transurethral resection of bladder tumor (TURBT) are investigated. For this purpose, total of 50 patients receiving TURBT areselected and randomly rolled into a control group
(Ctrl group, ONB under traditional resectoscope) and an experimental group (Exp group, self-adaptive algorithm-based ultrasound-guided ONB (algorithm+ultrasound ONB)). Each group contains 25 cases. The results of the comprehensive assessment of each index showed that the self-adaptive algorithm
enhanced the solution of ultrasonoscopy, which was morebeneficial for the intraoperative guidance on block. The success rate of the block in the Exp group reached 100%, higher than that in the Ctrl group (92%). The block time was 6.53±1.28 minutes, which was obviously shorter than that
in the Ctrl group (10.34±1.76 minutes). The incidence of complications (IoC) (16%) was significantly lower than that in the Ctrl group (36%). Besides, postoperative visual analogue scale/score (VAS) (2.01±0.84 points) was remarkably lower based on the score in theCtrl group (4.73±1.15
points). The above differences all show statistical significance (P <0.05). To sum up, self-adaptive algorithm could enhance the quality of surgical ultrasound-guided ONB, which showed significant values in the prevention of obturator nerve reflex, postoperative analgesia for patients,
and the recovery.
Promotion of Osseointegration Using a Titanium Oxide Nanotube Modified Biomimetic Nano-Structured Multi-Layer Implant
Authors: Xie Xueguan , Hu Hao , Dai Yankun , Huang Xu , Meng Shengdong , Zhan Qing , Ding Mingsheng
Published: May 2023

Objective: Construction of a novel biomimetic nano-structured multi-layer interface implant to induce osseointegration. Methods: Spark plasma sintering was used to create micron-scale trabecular bone biomimicry structures, surface modification with TiO2 nanotubes,
and micron-scale trabecular bone biomimicry/TiO2 nanotubes from pure titanium samples. The structure of the modified surface. Four groups (A, B, C, and D) of 40 female SD rats were randomly divided into each of the four groups and implanted with titanium, trabecular bone biomimetic
titanium, TiO2 nanotube surface modified titanium, and micron trabecular bone biomimetic/TiO2 nanotube surface modified trabecular titanium. Results: The proximal tibia and titanium implants underwent histological, micro-CT, and biomechanical testing after 12 weeks.
Conclusions: The best osseointegration was shown in Group D, which had the greatest osseointegration rate, relative bone volume, and total bone volume, as well as greater trabecular bone-related measures. It was also shown that group D had the highest maximum pushing force and critical
shear strength compared to the other three groups. Conclusion: Ultimately, the biomimetic nano-structured multi-layer implant improves the osseointegration of titanium implants, making it a suitable material for use in clinical therapy.
Extending Residual-Mean Overturning Theory to the Topographically Localized Transport in the Southern Ocean
Authors: Youngs Madeleine K. , Flierl Glenn R.
Published: May 2023

The Southern Ocean plays a major role in global air–sea carbon fluxes, with some estimates suggesting it contributes to up to 40% of the oceanic anthropogenic carbon dioxide uptake, despite only comprising about 20% of oceanic surface area. Thus, the Southern Ocean overturning, the circulation that transports tracers between the surface and deep ocean interior, is particularly important for climate. Recent studies show that vertical velocities and tracer transport are largest just downstream of bottom topography; these quantities are related to the overturning, but provide incomplete information about the net Lagrangian transport, usually described with the residual-mean theory in a zonally integrated sense. This study uses an idealized Southern Ocean–like channel model with particle tracking to visualize the thickness-weighted velocities that capture the net overturning transport of a parcel, connecting residual-mean overturning theory to the three-dimensional, localized nature of the overturning. From this, we split the flow into three main drivers of transport: a wind-driven Ekman pumping into or out of a density layer, and standing eddies and transient eddies, both of which are localized near the topography. In this framework, the three-dimensional overturning circulation is not a small residual between the eddy and Eulerian-mean transport. The existence of a ridge weakens the response of the overturning to changes in wind, especially in the lower cell. This local understanding of the overturning framework suggests that careful modeling and sampling of specific regions near topography in the Southern Ocean are vital to understand climate sensitivity, transport, carbon export, and connections with the oceans to the north.
Tension Pneumopericardium Causing Cardiogenic Shock due to Blunt Injury to the Chest
Authors: Pearl Leah , Kerby Emily , Pansuriya Shyamal , Alnajjar Raed , Lim John
Published: May 2023

Pneumopericardium is an exceptionally uncommon phenomenon in the setting of blunt polytrauma. It is imperative for trauma providers to identify tension pneumopericardium despite its rarity. A 22-year-old male motorcyclist presented to the hospital after colliding with a car going approximately 50 mph. The patient was hemodynamically unstable and had diminished breath sounds bilaterally. Bilateral chest tubes were placed, yielding little improvement in condition. While obtaining CT imaging, pneumopericardium was promptly identified. Pulses were lost immediately before pericardiocentesis, and resuscitative thoracotomy was performed. The pericardial sac was tense and an immediate gush of air released upon incising the sac. The patient was taken immediately to the Operating Room for further exploration and repair.