bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Pengaruh Kinerja Keuangan terhadap Alokasi Belanja Modal di Provinsi Jambi
Authors: Praza Eko Indra
Published: May 2022

Abstract.This research aimed to analyze the financial performance of the District/ Municipality in Jambi Province and to determine the effect of financial performance either simultaneously or partially on capital expenditure. The data used in this research is a panel data comprising time series data is data in 2010 - 2013 and cross section data is data of 9 (nine) District and 2 (two) Municipality is located in the Province of Jambi. The analytical method used panel data regression analysis. The analysis showed that the financial performance of the District/ Municipality in Jambi Province is still relatively low as the PAD contribution to regional revenue is still small so transfer income still dominate the local revenue to finance most of the regional expenditure. The results of panel data regression using the Fixed Effect Model (FEM) showed that the financial performance simultaneously significant effect on capital expenditure allocation of the District/Municipality in Jambi Province from 2010 to 2013 and partially Ratio Degree of Decentralization significant positive effect on the allocation of capital expenditure. Financial dependency ratio, Financial Independence Ratio and the ratio degrees contributions public enterprises significant negative effect on capital expenditure . Effectiveness ratio of PAD does not significantly influence the allocation of capital expenditure.Keyword: Financial Performance, Decentralization, Financial Independence,   Abstrak. Penelitian ini bertujuan untuk menganalisis kinerja keuangan Pemerintah Kabupaten/Kota di Provinsi Jambi dan untuk mengetahui pengaruh kinerja keuangan baik secara simultan maupun secara parsial terhadap alokasi belanja modal. Data yang digunakan dalam penelitian ini merupakan data panel yang terdiri dari data time series yaitu data tahun 2010 – tahun 2013 dan data cross section yaitu data 9 (sembilan) Kabupaten dan 2 (dua) Kota yang berada di Provinsi Jambi. Metode analisis yaitu analisis regresi data panel. Hasil analisis menunjukkan bahwa kinerja keuangan Kabupaten/Kota di Provinsi Jambi masih tergolong rendah. Hasil regresi data panel dengan menggunakan metode Fixed Effect Model (FEM) menunjukkan bahwa kinerja keuangan secara simultan berpengaruh signifikan terhadap alokasi belanja modal Kabupaten/Kota di Provinsi Jambi dari tahun 2010 sampai dengan tahun 2013 dan secara parsial  Rasio Derajat Desentralisasi berpengaruh positif signifikan terhadap alokasi belanja modal. Rasio Ketergantungan Keuangan, Rasio Kemandirian Keuangan dan Rasio Derajat Kontribusi BUMD berpengaruh negatif signifikan terhadap alokasi belanja modal. Rasio Efektifitas PAD tidak berpengaruh signifikan terhadap alokasi belanja modal. Kata Kunci : Kinerja Keuangan, Desentralisasi, Ketergantungan Keuangan
Pola dan Prilaku Konsumsi Masyarakat Muslim di Provinsi Jambi (Telaah Berdasarkan Tingkat Pendapatan dan Keimanan)
Authors: Amir Amri
Published: May 2022

This research aims to: 1) determine the characteristics and patterns of consumption of the Muslim community in Jambi Province is based on the type of work, education, income and the level of Iman; 2) relationship between type of work, education, income and level of Iman towards food consumption and for religious.The data used are primary data. The number of samples as 150 Muslim households by the "purposive random sampling", taking into account the allocation of the sample based on the status and social organization that followed. Data analysis using cross table and Chi-Square test. The results of this research: 1) The proportion of food consumption Muslim community for food at 43.48%, while for non-food needs reached 56.52%. 2). The proportion of spending on religious amounted to 28.08% of non-food expenditure, or 15.87% of the total expenditure. 3) There is a close link between type of work, education, income and level of religiosity with food and non food expenditure. The higher the education, income and Iman, then the food expenditure is lower. 4). The link between this type of work, education, income and the level of Iman related closely with the expenses of the religious. The higher the level of education, income and Iman, then the expenditure for the religious tend to be higher.
Pengaruh Perkembangan Industri Terhadap Penyerapan Tenaga Kerja di Provinsi Jambi
Authors: Muhtamil Muhtamil
Published: May 2022

This study aims to analyze the influence of industrial development on the absorption of manpower in districts/cities in Jambi Province. The data used are secondary data in district /cities of Jambi Province from 2010-2014, using panel data analysis. The result of the research shows that there is a significant positive influence between business unit variables, investment value and production value on employment absorption at districts/cities in Jambi Province. Keywords: labor, business units, investment, production. Abstrak. Penelitian ini bertujuan untuk menganalis pengaruh perkembangan industri terhadap penyerapan tenaga kerja pada kabupaten/kota di Provinsi Jambi. Data yang digunakan adalah data sekunder pada kabupaten/kota di Provinsi Jambi dari tahun 2010-2014, dengan menggunakan analisis data panel. Hasil penelitian menunjukkan terdapat pengaruh positif yang signifikan antara variabel unit usaha, nilai investasi dan nilai produksi terhadap penyerapan tenaga kerja pada kabupaten/kota di Provinsi Jambi.  Kata kunci: tenaga kerja,unit usaha, investasi, produksi.
National Policy on Food and Nutrition in the Family Food Fulfillment Practices in Aceh: Foucauldian Analysis on the Discourses of the Power of Human Body
Authors: Nulwita Maliati  , Sumarti Titik , Agusta Ivanovich , Tanziha Ikeu
Published: May 2022

This article aims to analyze national policies on food and nutrition in the family food fulfillment practices in Aceh. Various programs to address food and nutrition problems have been made but nutrition problems have not been successfully resolved. The results of the 2018 Basic Health Research (Riset Kesehatan Dasar, Riskesdas) showed that the prevalence of stunting for baby under two years old in Aceh is the highest in Indonesia. This article was based on Foucauldian theory and a qualitative approach, through interviews with 40 families having children under five years old to recall the type of food consumed by all family members for 3 x 24 hours The results show that there is a gap between the practice of fulfilling family food in Aceh and national policies on food and nutrition. The practice of fulfilling family food is focused on carbohydrates and animal protein, while the government promotes the fulfillment of a balanced diet between carbohydrates and proteins (animal and vegetable) with vegetables and fruits. The gap occurs because of differences in the discourses of the power of the body and benefits of food. The community understands that food aims to make the body able to function properly (body productivity discourse). Meanwhile, the government aims for the human body to grow and develop ideally to avoid degenerative diseases (healthy body discourse). Family food fulfillment practices depend on the power of women’s knowledge, especially mothers’ who have the main role in fulfilling family food.
Direct Epidural Metastasis of Breast Cancer Mimicking a Large Lumbar Disc Sequestrum: A Case Report and Review of Literature
Authors: Mirzashahi Babak , Razzaghof Mohammadreza , Irani Pouya Tabatabaei
Published: May 2022

Abstract We report a case of cauda equina syndrome (CES) caused by an
epidural metastasis of breast cancer, which oddly mimicked a large disc
sequestrum leading to misdiagnosis. To our knowledge, it is the first
report of the direct metastasis of breast cancer to epidural space.
An enhanced electron transport chain improved astaxanthin production in Phaffia rhodozyma
Authors: Luna-Flores Carlos , Wang Alexander , Hellens Juhani von , Speight Robert
Published: May 2022

Astaxanthin (AX) is a carotenoid pigment with antioxidant properties. AX
is used widely in the animal feed industry as a supplement. Wild-type
strains of Phaffia rhodozyma naturally produce low AX yields, but we
increased AX yields 50-fold in previous research using random
mutagenesis of P. rhodozyma CBS6938 and fermentation optimisation.
Genome sequencing linked phenotype and genome changes of the increased
AX production but relevant metabolic changes were not resolved. In this
study, the wild-type and the superior P. rhodozyma mutant strains were
grown in chemically defined media and instrumented fermenters.
Differential kinetic, metabolomics, and transcriptomics data were
collected. Our results suggest that carotenoid production was mainly
associated with cell growth and had a positive regulation of central
carbon metabolism metabolites associated with glycolysis, the pentose
phosphate pathway, the TCA cycle, and amino acids and fatty acids
biosynthesis. In the stationary phase, amino acids associated with the
TCA cycle increased, but most of the fatty acids and central carbon
metabolism metabolites decreased. TCA cycle metabolites such as
succinate, fumarate, and α-ketoglutarate were in abundance during both
growth and stationary phases. The overall observed metabolic changes in
the central carbon metabolism and abundance of TCA cycle metabolites
suggest an improvement in the electron transport chain and the provision
of the electrons required for the AX synthesis. Transcriptomic data
correlated with the metabolic data and found a positive regulation of
genes associated with the electron respiratory chain suggesting this to
be the main driver for improved AX production in the mutant strain.
Guidelines for the management of atopic dermatitis in children: A systematic review of the literature and quality appraisal with AGREE II
Authors: Wang Qi , Liu Lamei , Gao Shujing , Su Shaoyu
Published: May 2022

Background: Numerous guidelines have been published for atopic
dermatitis management in children in recent years. To date, the quality
of the newest guidelines has not been appraised. Objective: To
identify and evaluate guidelines for the management of atopic dermatitis
in children. Design: A review of the guidelines for the
management of atopic dermatitis in children and quality appraisal with
AGREE II was conducted. Methods: We reviewed literature
retrieved from PubMed, Web of Science, Ovid, ScienceDirect, Embase,
China National Knowledge Infrastructure, WanFang Data, and guidelines
websites. Search period from 1 January 2016 to 31 December 2021. The
following keywords were used for searching: ‘atopic dermatitis’, ‘atopic
eczema’, ‘eczema’, ‘guideline’ and ‘consensus’. The quality of the
guidelines was assessed by two assessors using the Appraisal of
Guidelines for Research & Evaluation II (AGREE II) instrument
independently, and domain scores were considered of sufficient quality
when > 60%. Guidelines recommendations were reviewed.
Results: Nineteen guidelines were included in the study. Three
guidelines were graded A level that recommended for use in practice.
Eleven guidelines were graded B level that recommended for use in
revision. The remaining five guidelines were rated C level not as
recommended. The average score of six domains of AGREE II was 64.76%,
48.53%, 42.35%, 73.83%, 32.23% and 70.17%, respectively. The
consistency test showed that ICC ranged from 0.497 (95%CI: 0.105,
0.705) to 0.970 (95%CI: 0.93, 0.987) in the results of two assessors’
tests of the guidelines. Conclusions: Most guidelines were
recommended for use with revision in the study. No major changes in
primary management of atopic dermatitis in children compared to previous
evidence. New biologic agents and complementary alternative medicine
were increasingly available, but evidence for the treatment of atopic
dermatitis in children was still limited.
Evaluation of the SIMULRESP: a simulation software of child and teenager cardiorespiratory physiology
Authors: Brossier David , Flechelles Olivier , Sauthier Michael , Engert Catherine , Chahir Youssef , Emeriaud Guillaume , Cheriet Farida , Jouvet Philippe , Montigny Simon de
Published: May 2022

BACKGROUND: Mathematical models based on the physiology when programmed
as a software can be used to teach cardiorespiratory physiology and to
forecast the effect of various ventilatory support strategies. We
developed a cardiorespiratory simulator for children called
“SimulResp”. The purpose of this study was to evaluate the quality of
SimulResp. METHODS: SimulResp quality was evaluated on accuracy,
robustness, repeatability and reproducibility. Blood gas values (pH,
PaCO , PaO and SaO )
were simulated for several subjects with different characteristics and
in different situations and compared to expected values available as
reference. The correlation between reference and simulated data was
evaluated by the coefficient of determination and Intraclass correlation
coefficient. The agreement was evaluated with the Bland & Altman
analysis. RESULTS: SimulResp produced healthy child physiological values
within normal range (pH 7.40 +/- 0.5; PaCO2 40 +/- 5 mmHg, PaO2 90 +/-
10 mmHg; SaO2 97% +/- 3%) starting from a weight of 25 to 35 kg,
regardless of ventilator support. SimulResp failed to simulate accurate
values for subjects under 25 kg and/or affected with pulmonary disease
and mechanically ventilated. Based on the repeatability was considered
as excellent and the reproducibility as mild to good. SimulResp’s
prediction remains stable within time. CONCLUSIONS: The
cardiorespiratory simulator SimulResp requires further development
before future integration into a clinical decision support system.
New insight into the molecular determinants of function, diversity and evolution of sweet taste receptors T1R2/T1R3 in primates
Authors: Wang Congrui , Liu Yi , Yu Haifeng , Cui Meng , Zhao Xiangzhong , Liu Bo
Published: May 2022

Sweet taste is a primary sensation for the preference and adaption of
primates to diet, which is crucial for their survival and fitness. It is
clear now that the sweet perception is mediated by a G protein-coupled
receptor (GPCR)-sweet taste receptor T1R2/T1R3, and many behavioral or
physiological experiments have revealed the diverse sweet taste
preferences and sensitivities in primates. However, the
structure-function relationship of T1R2s/T1R3s in primates, especially
the molecular basis for their species-specific sweet taste, has not be
well understood until now. In this study, we performed a comprehensive
sequence, structural and functional analysis of sweet taste receptors in
primates to elucidate the molecular determinants mediating their
species-dependent sweet taste recognition. Our results indicate
obviously distinct taxonomic distribution and classification, as well as
significant characteristics (interaction, coevolution and epistasis) for
several subsets of function-related potential residues, which could
partly account for the previously reported behavioral and physiological
results of taste perception in primates. Moreover, the prosimians
Lemuriformes species, which were reported to have no sensitivity to
aspartame, could be proposed to be aspartame tasters based on the
present analysis. Collectively, our study provides new insights and
promotes a better understanding for the diversity, function and
evolution of sweet taste receptors in primates.
Investigation of spermiotoxic, embryotoxic and cytotoxic effects of copper pyrithione on Paracentrotus lividus (Lamarck, 1816)
Authors: Taşcı Ezgi , Hayretdağ Sibel
Published: May 2022

Spermiotoxic, embryotoxic and cytotoxic effects of the widely used biofouling
biocide copper pyrithione (CuPt) were evaluated in bioassays to examine the
inhibition of fertilization rate, offspring quality and effects on early
development of the sea urchin Paracentrotus lividus. CuPt was
non-spermiotoxic for fertilization rates but the frequency of embryonic
malformations increased in a concentration-dependent manner when eggs were
fertilized with CuPt-exposed sperm. CuPt EC50 was calculated to be 13.58
?g/l for embryotoxicity. While the frequency of normally developed plutei
decreased, the number of larvae with skeletal deformations increased. The
IC25 and IC50 values in cytotoxicity assays were calculated to be 12.79 and
47.85 ?g/l, respectively. The study revealed statistically significant
decrease in the number of mitotically dividing cells, increase in the
percentage of interphase cells and increased chromosomal abnormalities in
the exposed cells. According to these results, CuPt can be said to have a
highly toxic effect on sea urchin embryos at the applied concentrations.
This situation suggests that there may be a potential risk of marine
contamination with CuPt for this species.
Reddish Tumour with Scar on the Right Thigh: A Quiz
Authors: Fukushiro Michihito , Chinuki Yuko , Ota Masataka , Honda Sakae , Yamasaki Osamu
Published: May 2022

Abstract is missing (Quiz)
Formulation and Evaluation of Polymeric Bilayer Matrix Tablet Containing Glipizide and Metformin Hydrochloride
Authors: Prabu S Lakshmana
Published: May 2022

The objective of the present study was to develop Bilayer tablets of Glipizide and metformin hydrochloride from polymeric matrices of HPMC K4M and Eudragit L-100. Drugs Glipizide and metformin hydrochloride are frontline anti-diabetic drugs prescribed in combination. Tablets were prepared by wet granulation method using different ratios of HPMC K4M and Eudragit L-100 and evaluated for its physicochemical properties, in vitro release profile and stability studies. The prepared granules physiochemical property results were within the limits and the formulated tablets hardness, friability and content uniformity was found to be between 5.1±0.1 and 5.9±0.3; 0.21 ±0.02 and 0.49±0.02%; 98.99 ±1.06 and 100.45±0.52 %w/w respectively. The invitro release was found to be observed for 12 hours in phosphate buffer pH 6.8 and compared with market formulation. The dissolution release of formulation was comparable with market formulation and the difference factor and similarity factor f1 and f2 were found to be 3.75 and 79.46 for metformin hydrochloride; 8.74 and 65.78 for glipizide respectively. Stability studies were carried out as per ICH guidelines and tested for its physicochemical properties and in vitro release studies. The stability study result reveals that the prepared formulation was stable.
Toxic Effect of Methylation and Chlorpyrifos on Liver of Male Rabbits
Authors: SAA Mohammed
Published: May 2022

The irrational use of organ phosphorus insecticides in Yemen play a crucial role in the occurrence of many diseases affecting plants, animals, and man. Methidathion (MD) and Chlorpyrifos (CF) are two of widely used organ phosphorus insecticides in agriculture. The purpose of the present study was to investigate the in vivo effect of (MD) and (CF) on lipid peroxidation (LPO), antioxidant defense system in the liver cells and liver function in male rabbits after orally administration a single dose of 1/8 of LD50 of (MD) and (CF) period of 20 days. Thirty healthy male rabbits weighting 1400-1600g., were divided into 3 groups with 10 animals in each, first group served as control animals, they received 3ml.of corn oil, while animals in second and third groups received 1/8 of LD50 of (MD) and (CF) respectively. The level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and gamma glutamyl transferase (γ-GT) in serum were analyzed, the level of (LPO), and methylglyoxal (MG), in liver homogenate were also studied. Results showed a significant (P<0.01) increase in all studied parameters in animals treated with (MD) and (CF) as compared to control animals. Our results indicated to the high toxicity of (MD) and (CF).
Bioavailability of Trans and Saturated Fatty Acids in Stuffed Cookies and Wafers Produced in Brazil
Authors: TCL Montilla
Published: May 2022

Several scientific studies highlight that trans fatty acids are harmful to health. The World Health Organization (WHO) considering the presence of trans fat in food recommends its total elimination by the year 2023. The Brazilian Health Surveillance Agency’s (ANVISA) Collegiate Board Resolution (RDC) No. 54, from November 2012, establishes that only foods with trans fat levels lower ≤ 0.1 g per portion can claim zero trans on the label. Stuffed cookies and wafers are important representatives of ultra-processed foods containing high levels of sugars and fats, being widely consumed for their low cost and accessibility. The objective of this study was to evaluate the levels of trans and saturated fat by gas chromatography (AOAC Official Method 996.06) in stuffed cookies and wafers, 31 stuffed cookies and 33 wafers were analyzed in the city of São Paulo, evaluating the amount of trans fats, between 0.01 to 1.56 g/serving and 0.01 and 2.56 g / serving in the filled wafers and cookies respectively. Therefore, it was found that some brands of stuffed wafers and wafers still present large amounts of trans fat in their composition causing risks to the consumer’s health
Bioequivalence of Oseltamivir Phosphate 6 mg/mL Powder for Oral Suspension Formulations in Healthy Thai Volunteers under Fasting Conditions
Authors: V Khaowroongrueng
Published: May 2022

Oseltamivir is an oral antiviral of choice indicated for treatment and prophylaxis of influenza A and B infections. Oseltamivir is an inactive prodrug of oseltamivir carboxylate, an active form exerting antiviral activity. Oseltamivir oral suspension is an alternative formulation for pediatric patients or adults with dysphagia. GPO-A-FLU ® , oseltamivir 6 mg/mL powder for oral suspension had been developed as a generic substitute for reference product, Tamiflu ® oral suspension. In this study, we investigated the pharmacokinetics and bioequivalence of the test oral suspension oseltamivir formulation with respect to the corresponding reference oral suspension formulation. A comparative open-label, randomized, single dose, two-way crossover study was conducted under fasting conditions. Blood samples were collected for 24 hours post-dose and the plasma was separated for oseltamivir assay using a validated liquid chromatography-mass spectrometry method. The pharmacokinetic parameters were determined from plasma concentration-time profiles after administration of the test and reference formulations. The pharmacokinetic parameters were in agreement with the previously published data. The primary pharmacokinetic parameters: AUC 0−tlast , AUC 0−  and C max obtained from 47 subjects who completed the study were statistically compared. The 90% confidence intervals of geometric least squares mean ratio (test/reference) for log-transformed parameters were within 80.00-125.00% of bioequivalence criteria: 92.33-98.52% for AUC 0−tlast , 92.28- 98.43% for AUC 0−  , and 81.82-94.26% for C max . Both products were generally well tolerated by healthy Thai subjects. This study successfully demonstrated bioequivalence between GPO-A-FLU ® and Tamiflu ® , and supported product registration.
Comparative Bioequivalence Studies of Two Metformin Extended- Release Formulations in Healthy Thai Volunteers
Authors: V Khaowroongrueng
Published: May 2022

Metformin is a first-line treatment for type 2 diabetic mellitus commonly used as a monotherapy or in a combination with other antidiabetic drugs. To control blood glucose levels, patients should be able to access to the treatment continuously. Thus, the Government Pharmaceutical Organization (GPO) had developed a generic metformin extended-release formulation as a low-cost alternative for patients and physicians. Two bioequivalence studies were conducted under fasting and fed conditions to compare the rate and extent of absorption between the test (Metformin XR 1000 mg) and reference (Glucophage XR 1000 mg) formulations. The study design for both studies was comparative randomized, open-label, single-dose, two-way crossover. Twenty-four subjects and fourteen eligible subjects were enrolled in the single-dose fasting and fed studies, respectively. Plasma concentrations of metformin were determined using a validated liquid chromatography tandem mass spectrometry method. The primary pharmacokinetics parameters including AUC 0-tlast , AUC 0−∞ and C max were statistically compared. The 90% confidence intervals of the geometric least squares mean ratio of log-transformed AUC 0-tlast , AUC 0−∞ and C max between the formulations were within 80.00-125.00% of bioequivalence criteria for both fasting and fed studies. The pharmacokinetic parameters following oral administration under fasting and fed conditions were comparable suggesting insignificant food effect on the absorption. The safety of metformin extended-release formulations was evaluated in healthy Thai subject. The test and reference products were well tolerated by the study subjects and no serious adverse events were reported in both studies. Based on the statistical indices, it was concluded that two metformin extended-release formulations were bioequivalent.
Effect of Dietary Inclusion of Ginger ( Zingiber officinale ) and Garlic ( Allium sativum ) Oil Mixture on the Growth Performance and Caecal Microbial Population of Broiler Chickens
Authors: JO Alagbe
Published: May 2022

The objective of the present study was to determine effect of dietary inclusion of ( Zingiber officinale ) and garlic ( Allium sativum ) oil mixture (GIGM) on the growth performance and caecal microbial population of broiler chickens. One hundred and fifty one-day-old broiler chicks (Ross 308) were randomly allocated into 5 treatments with three replicates consisting of 10 birds each in a completely randomized design. Birds in treatment 1 (T1) was fed basal diet with 0 % inclusion of GIGM while T2, T3, T4 and T5 were given 0.1 %, 0.2 %, 0.3 % and 0.4 % respectively. Clean feed and water were offered ad libitum and all other management practices were strictly observed throughout the experiment which lasted for 56 days. Results obtained were used to determine weight gain (WG), average daily weight gain (ADWG), total feed intake (TFI), average daily feed intake (ADFI), feed conversion ratio (FCR) and microbial population of E.coli , Salmonella spp and Lactobacillus spp. ADWG, ADFI and FCR were significantly (P ˂ 0.05) influenced by the dietary inclusion of GIGM. ADWG were highest in T5 (47.80 g), T4 (45.75 g) and T3 (45.09 g), intermediate in T2 (39.59 g) and lowest in T1 (30.72 g). Lactobacillus spp increased as the level of dietary inclusion of GIGM increases (P ˂ 0.05). E.coli and Salmonella spp counts were significantly (P ˂ 0.05) different among the treatments. It was concluded that GIGM could be included in the diet of broilers up to 0.4 % without causing any deleterious effect on the performance and health of birds.
A Typical Properties of Nanomaterials for Applications in Drug Delivery: A Review
Authors: S Lakshmana Prabu
Published: May 2022

Developing a new drug molecule is an interdisciplinary research. A new drug molecule takes 10-14 years to develop with a 0.01% success rate. The developed new drug is administered as conventional or sustained release dosage forms. Among the conventional and sustained release dosage forms, sustained release form has many advantages. In the 21 st century, nanotechnology has become an innovative field and the nanomaterials/nanoparticles made by this technology had specific atypical properties. An extensive research interest among the researchers made a new revolution and its application almost in all the fields. This nanotechnology in medicinal profession especially in drug delivery has developed several products for the treatment and cure of many diseases. This article summarizes the different nanomaterials, its atypical properties and outlines the different methods of nanoparticle preparations for applications in drug delivery
The Protective Effects of Different Types of Yemeni Honey on Hepatorenal Toxicity Induced by Gentamicin on Guinea Pigs
Authors: MSA Al-Awar
Published: May 2022

Aim: This study aimed to investigate the antioxidant properties of different types of Yemeni honey in reducing hepatotoxicity and nephrotoxicity caused by gentamicin in the female guinea pigs. Method and Results: The administration of Osaimi sider honey, Athel honey, Dam Al-Akhawain honey, Salam honey (5 mg/kg orally), Gentamicin (80 mg/kg i.p.), gentamicin+Osaimi sider honey, gentamicin+ Athel honey, gentamicin+ Dam Al-Akhawain honey, and gentamicin+ Salam honey for 7days caused a significant increase in the levels of AST and ALT, and also caused a significant decrease in the levels of total protein and albumin in gentamicin treated groups together with significant elevation in levels of urea and no significant increase in the level of creatinine. However, co-administration of gentamicin with different types of Yemeni honey used in this study ameliorated the harmful effects of gentamicin in most of the tested parameters. Different types of Yemeni honey used in this study have a protective effect on the histological changes of liver and kidney tissues induced either by gentamicin administration. Conclusion: The present study concluded that the use of antioxidants (Yemeni Honey) showed a highly significant protective effect on the functions and tissue of the liver and kidney when they were used as co-treatment. The effects of honey that were found in our experiment are due to the presence of many antioxidant compounds such as flavonoids, ascorbic acid, tocopherols, catalase, and phenolic compounds, that work together to provide a synergistic antioxidant effect, scavenging and eliminating free radicals. But the protective effect of the treatment with sider honey and Dam Al-Akhawain honey had a greater protective effect on the liver and the treatment with Dam Al-Akhawain honey and Athel honey had a greater protective effect on the kidney which was almost similar to the control.
Distinguish Thyroid Malignant from Benign Alterations Using X-Ray Fluorescence Analysis of Trace Element Contents in Nodular Tissue
Authors: V Zaichick
Published: May 2022

Introduction: Thyroid benign (TBN) and malignant (TMN) nodules are a common thyroid lesion. The differentiation of TMN often remains a clinical challenge and further improvements of TMN diagnostic accuracy are warranted. Objective: The aim of present study was to evaluate possibilities of using differences in trace elements (TEs) contents in nodular tissue for diagnosis of thyroid malignancy. Methods: Contents of TEs such as bromine (Br), copper (Cu), iron (Fe), iodine (I), rubidium (Rb), strontium (Sr), and zinc (Zn) were prospectively evaluated in nodular tissue of thyroids with TBN (79 patients) and to TMN (41 patients). Measurements were performed using energy-dispersive X-ray fluorescent analysis. Results: It was observed that in TMN tissue the mass fractions of Br, I and Zn were approximately 2.9, 20, and 1.3 times, respectively, lower while the mass fraction of Rb 41% higher than in TBN tissue. Contents of Cu, Fe, and Sr found in the TBN and TMN groups of nodular tissue samples were similar. Conclusions: It was proposed to use the I mass fraction and I/Rb mass fraction ratio in a needle-biopsy of thyroid nodules as a potential tool to diagnose thyroid malignancy. Further studies on larger number of samples are required to confirm our findings and proposals.
Chimeric Antigen Receptor T-Cell Therapy (Car T-Cells) in Solid Tumors, Resistance and Success
Authors: Y Elshimali
Published: May 2022

CARs are chimeric synthetic antigen receptors that can be introduced into an immune cell to retarget its cytotoxicity toward a specific tumor antigen. CAR T-cells immunotherapy demonstrated significant success in the management of hematologic malignancies. Nevertheless, limited studies are present regarding its efficacy in solid and refractory tumors. It is well known that the major concerns regarding this technique include the risk of relapse and the resistance of tumor cells, in addition to high expenses and limited affordability. Several factors play a crucial role in improving the efficacy of immunotherapy, including tumor mutation burden (TMB), microsatellite instability (MSI), loss of heterozygosity (LOH), the APOBEC Protein Family, tumor microenvironment (TMI), and epigenetics. In this minireview, we address the current and future applications of CAR T-Cells against solid tumors and their measure for factors of resistance and success.
Assessing the Chemical Composition of Wastewater Released from Hawassa Castel Brewery Plant and its Impact on Groundwater
Authors: ZH Melaku
Published: May 2022

Brewery plants have been known to cause pollution if they have no proper environmental safety systems by discharging effluent into the receiving stream, ground water and soil. The study aims to assess the physicochemical composition of wastewater generated from Hawassa Castel brewery plant and its impact on the surrounding environment particularly on the quality of ground-water. Thus, the study was conducted on samples taken from effluents of Hawassa Castel brewery plant and ground water from the nearby areas. Physicochemical parameters such as pH, temperature, DO, BOD, COD, TDS, TSS, EC, turbidity, nitrate, phosphate, sulphate, NH3-N, chloride, TN and TP were analyzed both for effluent samples and groundwater samples. Brewery effluent samples were collected from three sampling stations S1 (brewery effluent discharge point), S2 (50 m from brewery effluent discharge point downstream), and S3 (100 m from brewery effluent discharge point downstream) and four groundwater samples namely G1, G2, G3, G4 were also collected from near Hawassa Castel brewery plant. Groundwater samples G1 and G2 were collected approximately 30 m away from effluent discharge point and groundwater samples G3 and G4 were collected 100 m away from the stream. The parameters monitored for the quantitative analysis of brewery wastewater and ground water. The values of BOD (70.9 ± 7.69 mg/L), COD (178.5 ± 42.8 mg/L), TDS (135.5 ± 34.3 mg/L), turbidity (7.44 ± 0.77 NTU), and phosphate (9.08 ± 4.6 mg/L) were found to be above the permissible industrial effluents discharge limits. Moreover, the presence of high levels of TDS (462.8 ± 216.8 mg/L), TSS (143.7 ± 62.7 mg/L), EC (2370.9 ± 595 μS/cm), nitrate (43.5 ± 21.3 mg/L), phosphate (0.61 ± 0.13 mg/L), and chloride (931.9 ± 42.7 mg/L) in the ground-water samples were immensely polluted by anthropogenic activities and making it unsuitable for drinking purpose. Thus, the concerned bodies should act to prevent further deterioration of the quality of groundwater.
Simulation of statistical mean and variance of normally distributed random values, transformed by nonlinear functions $\sqrt{|X|}$ and $\sqrt{X}$
Authors:   Lviv Polytechnic National University, Karkulovska P. S. , Karkulovska M. S. ,   Lviv Polytechnic National University
Published: May 2022

This paper presents theoretical studies of formation regularities for the statistical mean and variance of normally distributed random values with the unlimited argument values subjected to nonlinear transformations of functions $\sqrt{|X|}$ and $\sqrt{X}$. It is shown that for nonlinear square root transformation of a normally distributed random variable, the integrals of higher order mean $n>1$ satisfy the inequality $\overline{(y-\overline{Y})^n}\neq 0$. On the basis of the theoretical research, the correct boundaries $m,\sigma \to \infty$ of error transfer formulas are suggested.
Implementasi Green Chemistry Menggunakan Teknologi Pirolisis Untuk Pengolahan Limbah Plastik Di Kelurahan Way Urang Kalianda
Authors: Sembiring Zipora , Nurhasanah Nurhasanah , Rinawati Rinawati , Simanjuntak Wasinton
Published: May 2022

Kelurahan Way Urang merupakan salah satu destinasi wisata pantai yang berpotensi menyumbang limbah plastik berlimpah. Salah satu metode pengolahan limbah plastik yang menerapkan prinsip Green Chemistry serta sederhana adalah metode pirolisis. Metode pirolisis dapat mengubah limbah atau sampah plastik menjadi bahan bakar yang dapat digunakan dalam keperluan sehari-hari. Pada kegiatan ini dilakukan pre-test dan post-test yang didasari pada pemaparan dan edukasi tentang prinsip-prinsip Green Chemistry, metode pirolisis serta jenis dan sifat bahan plastik yang dilanjutkan dengan demonstrasi pengolahan limbah plastik dengan metode pirolisis. Hasil evaluasi kegiatan menunjukkan peningkatan pengetahuan dan wawasan masyarakat terkait jenis plastik dan pengolahannya sebesar 51% sesudah penyampaian materi oleh narasumber. Melalui kegiatan pengabdian ini juga diharapkan Pemda dan masyarakat setempat saling sinergi menanggulangi limbah yang ada di daerah wisata agar dapat menunjang perekonomian daerah.
Pemanfaatan Limbah Biomassa Jagung Untuk Produksi Biochar di Desa Bangunsari, Pesawaran
Authors: Hidayat Wahyu , Haryanto Agus , Ibrahim Gusri Akhyar , Hasanudin Udin , Prayoga Seldi , Saputra Bagus , Rahman Alim Fadila , Tambunan Karina Gracia Agatha
Published: May 2022

Jagung merupakan komoditi unggulan di Desa Bangunsari, Pesawaran, namun hasil panen menyisakan limbah biomassa tongkol jagung. Selama ini limbah tongkol jagung hanya dibuang dan dibakar, sehingga menimbulkan masalah polusi, efek rumah kaca dan pemanasan global. Pemanfaatan limbah tongkol jagung sebagai bahan baku biochar dapat menjadi solusi yang menjanjikan. Kegiatan pengabdian kepada masyarakat (PKM) ini bertujuan untuk memperkenalkan manfaat penting biochar sebagai pembenah tanah kepada petani di Desa Bangunsari, membangun tungku produksi biochar, dan mempraktikkan cara membuat biochar dari tongkol jagung. Metode pengabdian menggunakan PLA (Participatory Learning and Action) dengan melibatkan beberapa petani yang dilatih dalam pembuatan biochar. Dari kegiatan PKM ini telah dibangun satu tungku produksi biochar dari batu bata dan tanah liat yang mampu memproses bahan baku berupa limbah tongkol jagung dengan kapasitas proses 35 meter kubik. Petani yang terlibat dalam kegiatan PKM ini mengerti proses pembuatan biochar menggunakan tungku tanah liat
Manajemen Pengawasan dalam Meningkatkan Kinerja Sekolah Menengah Atas Negeri 2 Kulisusu Kabupaten Buton Utara
Authors: Hasty Hasty , Alam Syamsul , Bida Obed
Published: May 2022

Supervision management is an effort to manage supervisory activities in order to improve organizational performance. Thus efforts to improve school performance can be pursued by improving the quality of supervisory management. This study was conducted to analyze supervisory management in improving school performance at SMAN 2 Kulisusu, North Buton Regency using qualitative methods. Informants in this study amounted to 9 people consisting of 8 school elements, 1 supervisor element selected by using purposive sampling technique. The data collected was then analyzed descriptively to obtain an overview of Supervisory Management and School Performance through Teacher Performance and Principal Performance. The results showed that the supervisory management carried out by SMAN 2 Kulisusu supervisors in improving school performance at SMAN 2 Kulisusu had not run optimally due to limited facilities and infrastructure that were not in accordance with needs, as well as limited operational budget supervision which led to revision activities to improve program actualization results. control cannot be carried out. In addition, the supervision stage also does not run optimally, especially at the implementation stage of supervision due to the low understanding of teachers on textual supervisor instructions and the low intensity of supervisory meetings with school principals.
Upaya Pengembangan Objek Wisata Air Terjun Tiga Pangung di Desa Ulak Bandung Kec. Muara Sahung Kab. Kaur
Authors: Susila Wati Dewi , Juim Juim , Darmi Titi
Published: May 2022

The purpose of this study is to find out the efforts and factors inhibiting the development of Tiga Pangung Waterfall Tourism Object in Ulak Village Bandung Kec. Muara Sahung Kab. Kaur. Researchers used qualitative descriptive research methods. The data source consists of primary and secondary data. Primary data is obtained through interviews to management actors. Data analysis techniques used by researchers through the stages of data collection, data reduction, data presentation, and verivication or data validation. Data validation is done by confirmation to the public. The results of research efforts to develop The Three Pangung Waterfall Tourism Object in Ulak Village Bandung Kec. Muara Sahung Kab. Kaur done quite well this is seen from the role of village officials, village heads, communities and the role of coral cadets in developing objerk Wisata empowerment of roads, maintaining cleanliness and infrastructure advice provided at the Three Pangung Waterfall Tourism Object in Ulak Village Bandung Kec. Muara Sahung Kab. Kaur. Factors Inhibiting the Development of Three Pangung Waterfall Attractions in Ulak Village Bandung Kec. Muara Sahung Kab. Kaur, which was found to include a lack of facilities and infrastructure, human resources that do not play an active role, funds and lack of coaching conducted by the tourism and cultural office.
Strategi Pembelajaran Matematika Mengenal Nilai dan Angka Melalui Bermain dan Benda-Benda Konkret pada Anak Usia Dini
Authors: Husna Amalia , Nurhafizah Nurhafizah
Published: May 2022

Mathematics is one of the cognitive aspects that must be introduced to children at an early age to achieve a standard of cognitive development called the Child Development Achievement Level Standard (STPPA) as stated in the Regulation of the Minister of Education and Culture of the Republic of Indonesia Number 137 of 2014. One of the basic learning Mathematics is a child recognizes the concept of numbers and understands numbers. So that children's understanding is in accordance with the concept, children must learn mathematics from concrete objects and by playing. the introduction of values ​​and numbers in children aged 2-8 years children need concrete objects, because at this age, children recognize concepts using symbols. This study aims to find a strategy for learning mathematics to recognize values ​​and numbers through play and concrete objects in early childhood. This type of research is descriptive qualitative with literature study method. As for the results of the research, the strategies that can be used in introducing children to numbers through play and concrete objects are: (1) Singing; (2) Flannel Board Media; (3) Calendar Games; (4) Number Card; (5) Counting Things in Daily Life; (6) Dice; (7) Write Numbers (8) Number Fishing Media; (9) Snakes and Ladders Game; (10); Congklak Game; (11) Finger Method.
Ebeveynlerin bağlanma biçimlerinin çocuk yetiştirme tutumları üzerindeki yordayıcı rolü
Authors: Akatlı Rana , Tunçay Güzin Yasemin
Published: May 2022

Bu çalışmada, ebeveynlerin bağlanma örüntüleri ile çocuklarını yetiştirme tutumları arasındaki ilişkinin incelenmesi amaçlanmaktadır. Araştırmanın örneklemi Elazığ ilinde yaşayan, 2-6 yaş arasında çocukları bulunan 18-60 yaş arası 293 (185 kadın/108 erkek) ebeveynden oluşmaktadır. Araştırmada veri toplama aracı olarak “Kişisel Bilgi Formu”, “Ebeveyn Tutum Ölçeği” ve “Erişkin Bağlanma Biçimleri Ölçeği” kullanılmıştır. Araştırmada veriler; pearson korelasyon ve çoklu regresyon analizi istatistik yöntemleriyle analiz edilmiştir. Araştırma bulgularına göre; demokratik tutum ile kaçıngan bağlanma ve güvenli bağlanma arasında negatif; otoriter tutum ile kaçıngan bağlanma ve güvenli bağlanma arasında pozitif; aşırı koruyucu tutum ile kaçıngan bağlanma arasında pozitif yönde ilişki bulunmuştur. Araştırma sonuçlarına göre eğitim düzeyi ve ebeveynlerin yaşı demokratik tutumun önemli yordayıcılarındandır. Ebeveynlerin; evlendiği yaşın, izin verici tutum düzeyini yordamada pozitif; çocuk sayısının, izin verici tutum düzeyini yordamada negatif; erkek çocuğu sayısının ise otoriter tutum düzeyini yordamada pozitif yönlü ve anlamlı katkısı bulunmuştur.
60-72 aylık çocukların mizaç özellikleri ile problem çözme becerileri arasındaki ilişkinin incelenmesi
Authors: Akçay Çağla Elif , Alabay Erhan
Published: May 2022

Araştırmanın amacı, 60-72 aylık çocukların mizaç özellikleri ile problem çözme becerileri arasındaki ilişkinin incelenmesidir. Çalışma grubunu; 2018-2019 eğitim-öğretim yılı İstanbul ili Millî Eğitim Bakanlığı’na bağlı resmi eğitim veren bağımsız okul öncesi eğitim kurumuna devam eden 60-72 aylık 168 çocuktan oluşmaktadır. Çalışmada nicel araştırma desenlerinden ilişkisel tarama yönteminden yararlanılmıştır. Araştırmada “Aile Çocuk Demografik Bilgi Formu”, “Çocuklar İçin Kısa Mizaç Ölçeği” ve “Problem Çözme Becerisi Ölçeği” kullanılmıştır. Çalışmanın sonucunda, çocukların Mizaç Ölçeği Sıcakkanlılık alt boyutundan en yüksek puana sahip oldukları tespit edilirken, en düşük puanı Tepkisellik alt boyutundan aldıkları belirlenmiştir. Sebatkarlık alt boyutunda kız çocuklarının erkek çocuklarına göre daha yüksek puan aldıkları saptanmıştır. Bir diğer ifade ile kızların erkeklere oranla daha fazla sebatkar olduğu belirlenmiştir. Çocukların problem çözme becerisi ile sıcakkanlılık ve sebatkarlık mizaç puanları arasında orta düzeyde pozitif yönlü anlamlı bir ilişki vardır. Ayrıca çocukların tepkisellik mizaç puanları ile problem çözme becerisi arasında negatif yönlü orta düzeyde anlamlı bir ilişkiye rastlanmıştır.
El tiempo y el espacio en los códices mixtecos desde el diseño para la visualización de la información
Authors:   , Méndez  Escarza Claudia Rebeca
Published: May 2022

Los códices mesoamericanos son libros con lenguaje pictográfico elaborados antes y después de la llegada de los españoles a México. Éstos han sido estudiados desde distintas disciplinas, principalmente desde la Antropología, cuyas traducciones han propiciado su interpretación de una lengua a otra. No obstante, estos documentos no han sido investigados desde el enfoque del Diseño o de la Visualización de Información. El Diseño de Información se enfoca en transmitir datos con el fin de generar entendimiento. Éste propicia en las personas, el logro de un determinado objetivo. Comúnmente se relaciona con infografías, aunque existe una diversidad de artefactos en los que se estructuran, organizan y presentan datos transformados en información comprensible. Por ello, se establece como propósito de esta investigación doctoral identificar y describir la manera en que se representan el tiempo y el espacio en los códices mixtecos empleando un método de análisis diseñado para ello y basado en cuatro disciplinas entre las que se incluyen el Diseño Visual y el Diseño de Información. Para llevar a cabo esta tesis se realizaron dos investigaciones; la primera fue la inmersión inicial en el manuscrito con la que se pudo comprender que el Códice Zouche Nuttall sí informa. Posteriormente se elaboró el marco teórico de los conceptos de tiempo y espacio. Se fundamentó la conformación del método diseñado para esta investigación, el cual se utilizó para la investigación principal, cuyos hallazgos se reportan y se discuten en este informe. Este método constituye una aportación para el campo del Diseño. Se fundamenta en cuatro disciplinas y se compone de tres etapas. Éstas conforman un proceso de análisis minucioso que permite describir verbalmente la información narrativa, iconográfica y visual presente en el códice. Además, el estudio del manuscrito llevado a cabo con este método permite estudiarlo como un relato visual por lo que ofrece alternativas a la interpretación antropológica. Se identificaron símbolos que marcan el tiempo y pictogramas que definen el espacio. Los primeros facilitan la percepción del tiempo y la manera en que transcurre. Los segundos favorecen la percepción del espacio, se emplean de manera esquematizada y ayudan a dar énfasis a distintos componentes narrativos del relato.