bluuebunny/crossref_metadata_2025 huggingface dataset:
A Complex Unit Interviews Analysis Approach in Qualitative Social Work Research
Authors: Koren Chaya
Published: April 2023

Qualitative research methods are advancing from individual analysis levels to dyadic and above to present multiple facets of reality, coinciding well with micro (individual), mezzo (family and groups) and macro (communities and society) levels in social work (SW) practices. Complex units (CU) comprise two groups with several members in each group, with each CU member having a perspective on the studied phenomenon; some perspectives are in congruence, others not. However, methodological approaches to the analysis of CUs are lacking. Based on the naturalistic–constructivist paradigm, this methodological article aims to present a Complex Unit Interviews Analysis (CUIA) approach that can be used in qualitative SW research. It includes a four-phase circular procedure: Phase 1—full analysis (i) familiarisation, (ii) coding, (iii) identifying themes; Phase 2—selective analysis of how a theme plays out in a CU (i) vertical analysis (across interviews within each CU group) and (ii) horizontal analysis (between groups of a CU); Phase 3—refining themes by analysis across CUs; Phase 4—conducting Phase 2 and Phase 3 for each theme identified in Phase 1. CUIA is illustrated using a family study case that presents multiple facets of a phenomenon’s reality by combining individual perspectives to form a CU perspective within SW and familial contexts.
Development of a Liquid-Phase Microextraction Method Prior to HPLC Analysis of Quercetin in Food Samples
Authors: Ghasemi Maryam , Rahmani Mashaallah , Khajeh Mostafa
Published: April 2023

In this research, an efficient, fast, low-cost and easy-to-use liquid-phase microextraction method was established to measure quercetin in onion and tomato before analysis by HPLC instrument. Herein, a rotatable central composite design-response surface methodology and artificial neural network were applied to model, optimize and predict the affecting factors on the microextraction procedure. Here, a minimal level of extractant was applied in the absence of a disperser. The cloudy state was formed by repeatedly suctioning and injecting the mixture of the aqueous solution and extractant with a glass syringe. Due to this procedure, a turbid solution composed of the very fine droplets of extractant dispersed in the aqueous solution was created, the contact surface was significantly enlarged and the quercetin was promptly extracted. The optimum values for the proposed method included 284 μL of 1-undecanol as the organic extractive solvent, pH of sample 3.3, the number of air injected nine times and speed and duration of centrifugation 4,000 rpm and 5 min. The linear range and detection of limit were achieved at 20–4,000 and 6 μg L−1, respectively. RSD% was obtained ˂4.93% (n = 5). This model was applied to monitor quercetin in tomato and onion samples.
Pharmacokinetic relevance of glomerular hyperfiltration for drug dosing
Authors: Zoccali Carmine , Mallamaci Francesca , De Caterina Raffaele
Published: April 2023

In chronic kidney disease (CKD) patients, hypofiltration may lead to the accumulation of drugs that are cleared mainly by the kidney and, vice versa, hyperfiltration may cause augmented renal excretion of the same drugs. In this review we mainly focus on the issue of whether hyperfiltration significantly impacts the renal clearance of drugs and whether the same alteration may demand an up-titration of the doses applied in clinical practice. About half of severely ill, septic patients and patients with burns show glomerular hyperfiltration and this may lead to enhanced removal of drugs such as hydrophilic antibiotics and a higher risk of antibiotic treatment failure. In general, hyperfiltering obese individuals show higher absolute drug clearances than non-obese control subjects, but this depends on the body size descriptor adopted to adjust for fat excess. Several mechanisms influence pharmacokinetics in type 2 diabetes, including renal hyperfiltration, reduced tubular reabsorption and augmented tubular excretion. However, no consistent pharmacokinetic alteration has been identified in hyperfiltering obese subjects and type 2 diabetics. Non-vitamin K antagonist oral anticoagulants (NOACs) have exhibited lower plasma concentrations in hyperfiltering patients in some studies in patients with atrial fibrillation, but a recent systematic review failed to document any excess risk for stroke and systemic embolism in these patients. Hyperfiltration is common among severely ill patients in intensive care units and drug levels should be measured whenever possible in these high-risk patients to prevent underdosing and treatment failure. Hyperfiltration is also common in patients with obesity or type 2 diabetes, but no consistent pharmacokinetic alteration has been described in these patients. No NOAC dose adjustment is indicated in patients with atrial fibrillation being treated with these drugs.
The place of cyclical therapy for the treatment of membranous nephropathy in the era of rituximab
Authors: Alberici Federico , Mescia Federica , Scolari Francesco
Published: April 2023

Primary membranous nephropathy (MN) is the most frequent cause of nephrotic syndrome in adults, due to a variety of autoantibodies, most frequently against phospholipase A2 receptor (PLA2R). In severe cases or when spontaneous remission is not achieved, immunosuppression is required. Cyclical therapy, based on glucocorticoids and cyclophosphamide on alternate months for 6 months, has proven effective to induce remission and reduce the risk of end-stage renal disease. Since the early 2000s, rituximab (RTX) has emerged as a key player in the management of MN, showing overall comparable effectiveness and likely better safety compared with the cyclical regimen, despite the lack of adequately powered trials comparing the two approaches head to head. For these reasons, RTX is now considered the agent of choice for most patients with MN. However, there are still uncertainties. Around 20–40% of patients are resistant to RTX, especially in the setting of high anti-PLA2R levels, and this drug remains relatively unexplored in patients with the most severe disease. In these scenarios, although the expanding therapeutic armamentarium is probably going to provide further options, the cyclical regimen still plays a key role as a safety net. The aim of this article is to illustrate the role of cyclical therapy in the RTX era.
Microtubule plus-end tracking proteins: novel modulators of cardiac sodium channels and arrhythmogenesis
Authors: Marchal Gerard A , Galjart Niels , Portero Vincent , Remme Carol Ann
Published: April 2023

The cardiac sodium channel NaV1.5 is an essential modulator of cardiac excitability, with decreased NaV1.5 levels at the plasma membrane and consequent reduction in sodium current (INa) leading to potentially lethal cardiac arrhythmias. NaV1.5 is distributed in a specific pattern at the plasma membrane of cardiomyocytes, with localization at the crests, grooves, and T-tubules of the lateral membrane and particularly high levels at the intercalated disc region. NaV1.5 forms a large macromolecular complex with and is regulated by interacting proteins, some of which are specifically localized at either the lateral membrane or intercalated disc. One of the NaV1.5 trafficking routes is via microtubules (MTs), which are regulated by MT plus-end tracking proteins (+TIPs). In our search for mechanisms involved in targeted delivery of NaV1.5, we here provide an overview of previously demonstrated interactions between NaV1.5 interacting proteins and +TIPs, which potentially (in)directly impact on NaV1.5 trafficking. Strikingly, +TIPs interact extensively with several intercalated disc- and lateral membrane-specific NaV1.5 interacting proteins. Recent work indicates that this interplay of +TIPs and NaV1.5 interacting proteins mediates the targeted delivery of NaV1.5 at specific cardiomyocyte subcellular domains, while also being potentially relevant for the trafficking of other ion channels. These observations are especially relevant for diseases associated with loss of NaV1.5 specifically at the lateral membrane (such as Duchenne muscular dystrophy), or at the intercalated disc (for example, arrhythmogenic cardiomyopathy), and open up potential avenues for development of new anti-arrhythmic therapies.
Twenty-five years of root remodelling for root aneurysm and tricuspid aortic valve
Authors: Ehrlich Tristan , Abeln Karen B , Burgard Christian , Froede Lennart , Schulze-Berge Julia , Morgenthaler Lucie , Giebels Christian , Schäfers Hans-Joachim
Published: April 2023

OBJECTIVES

The aim of this retrospective study was to assess the long-term results of root remodelling with tricuspid aortic valves and the effects of concomitant cusp repair and annuloplasty.

METHODS

Between October 1995 and December 2021, 684 patients with root aneurysm and regurgitant tricuspid valves were treated by root remodelling. The mean age was 56.5 [standard deviation (SD): 14] years, and 538 (77.6%) were male. Relevant aortic regurgitation was present in 68.3%. Concomitant procedures were performed in 374 patients. The long-term results were analysed. The mean follow-up of 7.2 (SD: 5.3) years (median 6.6 years); it was 95% complete (4934.4 patient-years).

RESULTS

Cusp prolapse was repaired in 83%, and an annuloplasty was added in 353 instances (51.6%). Hospital mortality was 2.3%, and survival was 81.7% (SD: 1.2) and 55.7% (SD: 5.8) at 10 and 20 years; age and measurement of effective height were independent predictors for death. Freedom from Aortic insufficiency (AI) II was 90.5 (SD: 1.9) at 10 years and 76.7 (SD: 4.5) at 20 years. Cusp repair of all cusps showed a lower freedom from recurrent AI ≥II at 10 years (P < 0.001). Suture annuloplasty showed a lower freedom from recurrent AI II at 10 years (P = 0.07). Freedom from reoperation was 95.5 (SD: 1.1) and 92.8 (SD: 2.8) at 10 and 20 years. The addition of an annuloplasty showed no difference (P = 0.236). Cusp repair had no effect on valve durability (P = 0.390).

CONCLUSIONS

Root remodelling leads to good long-term stability. The addition of cusp repair improves the valve stability over time. The addition of suture annuloplasty improves early valve competency; it showed no effect on freedom from reoperation up to 10 years.
A spatial and contextual exposome-wide association study and polyexposomic score of COVID-19 hospitalization
Authors: Hu Hui , Laden Francine , Hart Jaime , James Peter , Fishe Jennifer , Hogan William , Shenkman Elizabeth , Bian Jiang
Published: April 2023

Environmental exposures have been linked to COVID-19 severity. Previous studies examined very few environmental factors, and often only separately without considering the totality of the environment, or the exposome. In addition, existing risk prediction models of severe COVID-19 predominantly rely on demographic and clinical factors. To address these gaps, we conducted a spatial and contextual exposome-wide association study (ExWAS) and developed polyexposomic scores (PES) of COVID-19 hospitalization leveraging rich information from individuals’ spatial and contextual exposome. Individual-level electronic health records of 50 368 patients aged 18 years and older with a positive SARS-CoV-2 PCR/Antigen lab test or a COVID-19 diagnosis between March 2020 and October 2021 were obtained from the OneFlorida+ Clinical Research Network. A total of 194 spatial and contextual exposome factors from 10 data sources were spatiotemporally linked to each patient based on geocoded residential histories. We used a standard two-phase procedure in the ExWAS and developed and validated PES using gradient boosting decision trees models. Four exposome measures significantly associated with COVID-19 hospitalization were identified, including 2-chloroacetophenone, low food access, neighborhood deprivation, and reduced access to fitness centers. The initial prediction model in all patients without considering exposome factors had a testing-area under the curve (AUC) of 0.778. Incorporation of exposome data increased the testing-AUC to 0.787. Similar findings were observed in subgroup analyses focusing on populations without comorbidities and aged 18–24 years old. This spatial and contextual exposome study of COVID-19 hospitalization confirmed previously reported risk factor but also generated novel predictors that warrant more focused evaluation.
Price Volatility Modeling for the Lumber Futures Market: A Generalized Autoregressive Conditional Heteroskedasticity-Mixed Data Sampling Approach
Authors: Deb Prokash , Assogba Noel Perceval , Li Wenying
Published: April 2023

Lumber is one of the most essential forest products in the United States. During the first year of the COVID-19 pandemic, lumber prices almost quadrupled, and fluctuations reached record levels. Although market experts have pointed to various drivers of such high price volatility, no firm conclusions have been drawn yet. Using the generalized autoregressive conditional heteroskedasticity-mixed data sampling (GARCH-MIDAS) framework, this study assesses the potential drivers of lumber price volatility, with predictors including the Google Trends Web Search Index, housing starts, US lumber production quantity, and VIX index, representing public attention, housing demand, lumber supply, and macroeconomic concerns, respectively. We have found that housing demand is the key driver of lumber price volatility, followed by public attention. It is worth noting that US lumber supply and macroeconomic concerns have played a modest role in explaining lumber price volatility. Also, forecasting lumber price by using the housing demand variable substantially outperforms others. Market participants, including lumber mills, wholesalers, and home builders can get valuable information from the housing market to manage lumber price risk.
Oxidation Driven Reversal of PIP2-dependent Gating in GIRK2 Channels
Authors: Lee Sun-Joo , Maeda Shoji , Gao Jian , Nichols Colin G
Published: April 2023

Physiological activity of G protein gated inward rectifier K+ (GIRK, Kir3) channel, dynamically regulated by three key ligands, phosphoinositol-4,5-bisphosphate (PIP2), Gβγ, and Na+, underlies cellular electrical response to multiple hormones and neurotransmitters in myocytes and neurons. In a reducing environment, matching that inside cells, purified GIRK2 (Kir3.2) channels demonstrate low basal activity, and expected sensitivity to the above ligands. However, under oxidizing conditions, anomalous behavior emerges, including rapid loss of PIP2 and Na+-dependent activation and a high basal activity in the absence of any agonists, that is now paradoxically inhibited by PIP2. Mutagenesis identifies two cysteine residues (C65 and C190) as being responsible for the loss of PIP2 and Na+-dependent activity and the elevated basal activity, respectively. The results explain anomalous findings from earlier studies and illustrate the potential pathophysiologic consequences of oxidation on GIRK channel function, as well as providing insight to reversed ligand-dependence of Kir and KirBac channels.
Single-Cell RNA Sequencing Reveals Microevolution of the Stickleback Immune System
Authors: Fuess Lauren E , Bolnick Daniel I
Published: April 2023

The risk and severity of pathogen infections in humans, livestock, or wild organisms depend on host immune function, which can vary between closely related host populations or even among individuals. This immune variation can entail between-population differences in immune gene coding sequences, copy number, or expression. In recent years, many studies have focused on population divergence in immunity using whole-tissue transcriptomics. But, whole-tissue transcriptomics cannot distinguish between evolved differences in gene regulation within cells, versus changes in cell composition within the focal tissue. Here, we leverage single-cell transcriptomic approaches to document signatures of microevolution of immune system structure in a natural system, the three-spined stickleback (Gasterosteus aculeatus). We sampled nine adult fish from three populations with variability in resistance to a cestode parasite, Schistocephalus solidus, to create the first comprehensive immune cell atlas for G. aculeatus. Eight broad immune cell types, corresponding to major vertebrate immune cells, were identified. We were also able to document significant variation in both abundance and expression profiles of the individual immune cell types among the three populations of fish. Furthermore, we demonstrate that identified cell type markers can be used to reinterpret traditional transcriptomic data: we reevaluate previously published whole-tissue transcriptome data from a quantitative genetic experimental infection study to gain better resolution relating infection outcomes to inferred cell type variation. Our combined study demonstrates the power of single-cell sequencing to not only document evolutionary phenomena (i.e., microevolution of immune cells) but also increase the power of traditional transcriptomic data sets.
Molecular mechanisms underlying hematophagia revealed by comparative analyses of leech genomes
Authors: Zheng Jinghui , Wang Xiaobo , Feng Tong , Rehman Saif ur , Yan Xiuying , Shan Huiquan , Ma Xiaocong , Zhou Weiguan , Xu Wenhua , Lu Liying , Liu Jiasheng , Luo Xier , Cui Kuiqing , Qin Chaobin , Chen Weihua , Yu Jun , Li Zhipeng , Ruan Jue , Liu Qingyou
Published: April 2023

Background

Leeches have been used in traditional Chinese medicine since prehistoric times to treat a spectrum of ailments, but very little is known about their physiological, genetic, and evolutionary characteristics.

Findings

We sequenced and assembled chromosome-level genomes of 3 leech species (bloodsucking Hirudo nipponia and Hirudinaria manillensis and nonbloodsucking Whitmania pigra). The dynamic population histories and genome-wide expression patterns of the 2 bloodsucking leech species were found to be similar. A combined analysis of the genomic and transcriptional data revealed that the bloodsucking leeches have a presumably enhanced auditory sense for prey location in relatively deep fresh water. The copy number of genes related to anticoagulation, analgesia, and anti-inflammation increased in the bloodsucking leeches, and their gene expressions responded dynamically to the bloodsucking process. Furthermore, the expanded FBN1 gene family may help in rapid body swelling of leeches after bloodsucking, and the expanded GLB3 gene family may be associated with long-term storage of prey blood in a leech's body.

Conclusions

The high-quality reference genomes and comprehensive datasets obtained in this study may facilitate innovations in the artificial culture and strain optimization of leeches.
An Enhanced Euler Characteristic of Sutured Instanton Homology
Authors: Li Zhenkun , Ye Fan
Published: April 2023

For a balanced sutured manifold $(M,\gamma )$, we construct a decomposition of $SHI(M,\gamma )$ with respect to torsions in $H=H_{1}(M;\mathbb {Z})$, which generalizes the decomposition of $I^{\sharp }(Y)$ in a previous work of the authors. This decomposition can be regarded as a candidate for the counterpart of the torsion spin$^{c}$ decompositions in $SFH(M,\gamma )$. Based on this decomposition, we define an enhanced Euler characteristic $\chi _{\textrm {en}}(SHI(M,\gamma ))\in \mathbb {Z}[H]/\pm H$ and prove that $\chi _{\textrm {en}}(SHI(M,\gamma ))=\chi (SFH(M,\gamma ))$. This provides a better lower bound on $\dim _{\mathbb {C}}SHI(M,\gamma )$ than the graded Euler characteristic $\chi _{\textrm {gr}}(SHI(M,\gamma ))$. As applications, we prove instanton knot homology detects the unknot in any instanton L-space and show that the conjecture $KHI(Y,K)\cong \widehat {HFK}(Y,K)$ holds for all $(1,1)$-L-space knots and constrained knots in lens spaces, which include all torus knots and many hyperbolic knots in lens spaces.
Structured Immune Workup in Healthy Children With a First Episode of Severe Bacterial Infection: A 7-year Single-Center Study
Authors: Strasser Sophie , Relly Christa , Berger Christoph , Trück Johannes
Published: April 2023

Background

Severe bacterial infections (SBIs) in otherwise healthy children are rare and may represent an underlying impairment of the immune system, including primary immunodeficiency. However, it is unclear whether and how children should be assessed.

Methods

We retrospectively analyzed data from hospital records of previously healthy children aged 3 days to 18 years with SBI, including pleuropneumonia, meningitis, and/or sepsis. Patients were diagnosed or immunologically followed up between 1 January 2013 and 31 March 2020.

Results

Among 432 children with SBI, findings could be analyzed in 360. Follow-up data were available for 265 children (74%), of whom 244 (92%) underwent immunological testing. Laboratory abnormalities were found in 51 of 244 patients (21%), with 3 deaths (1%). Fourteen children (6%) had immunodeficiency considered clinically relevant (3 complement deficiencies, 1 autoimmune neutropenia, 10 humoral immunodeficiencies), and 27 (11%) had milder humoral abnormalities or findings suggestive of delayed adaptive immune maturation.

Conclusions

A substantial proportion of children with SBI may benefit from routine immunological testing, revealing (potentially) clinically relevant impaired immune function in 6%–17% of children. The identification of immune abnormalities allows for specific counseling of families and optimization of preventive measures, such as booster vaccinations, to avoid future SBI episodes.
Effect analysis of multi-department cooperation in improving etiological submission rates before antibiotic treatment
Authors: Lao YiQun , Tang QiJiang , Zeng Juan , Gong WeiWei , Shen YuYing
Published: April 2023

Increased bacterial drug resistance has become a serious global public health problem. The application of antibiotics involves various clinical departments, and the rational application of antibiotics is the key to improving their efficacy. To provide a basis for further improving the etiological submission rate and standardizing the rational use of antibiotics, this article discusses the intervention effect of multi-department cooperation in improving the etiological submission rate before antibiotic treatment. A total of 87 607 patients were divided into a control group (n = 45 890) and an intervention group (n = 41 717) according to whether multi-department cooperation management was implemented. The intervention group involved the patients hospitalized from August to December 2021, while the control group involved the patients hospitalized from August to December 2020. The submission rates of the two groups; the rates before antibiotic treatment at the unrestricted use level, the restricted use level, and the special use level in departments; and the timing of submission were compared and analysed. The overall differences in the etiological submission rates before antibiotic treatment at the unrestricted use level (20.70% vs 55.98%), the restricted use level (38.23% vs 66.58%), and the special use level (84.92% vs 93.14%) were statistically significant before and after intervention (P < .05). At a more specific level, the etiological submission rates of different departments before antibiotic treatment at the unrestricted use level, the restricted use level, and the special use level were improved, but the special activities of multi-department cooperation management did not improve the submission timing significantly. Multi-department cooperation can effectively improve the etiological submission rates before antimicrobial treatment, but it is necessary to improve measures for specific departments to improve long-term management and incentive and restraint mechanisms.
The anti-inflammatory and anti-oxidative effect of a classical hypnotic bromovalerylurea mediated by the activation of NRF2
Authors: Takeda Haruna , Nakajima Yoshihiro , Yamaguchi Teruaki , Watanabe Itaru , Miyoshi Shoko , Nagashio Kodai , Sekine Hiroki , Motohashi Hozumi , Yano Hajime , Tanaka Junya
Published: April 2023

The Kelch-like ECH-associated protein 1–nuclear factor erythroid 2-related factor 2 (KEAP1–NRF2) system plays a central role in redox homeostasis and inflammation control. Oxidative stress or electrophilic compounds promote NRF2 stabilization and transcriptional activity by negatively regulating its inhibitor, KEAP1. We have previously reported that bromovalerylurea (BU), originally developed as a hypnotic, exerts anti-inflammatory effects in various inflammatory disease models. However, the molecular mechanism underlying its effect remains uncertain. Herein, we found that by real-time multicolor luciferase assay using stable luciferase red3 (SLR3) and green-emitting emerald luciferase (ELuc), BU potentiates NRF2-dependent transcription in the human hepatoblastoma cell line HepG2 cells, which lasted for more than 60 h. Further analysis revealed that BU promotes NRF2 accumulation and the transcription of its downstream cytoprotective genes in the HepG2 and the murine microglial cell line BV2. Keap1 knockdown did not further enhance NRF2 activity, suggesting that BU upregulates NRF2 by targeting KEAP1. Knockdown of Nfe2l2 in BV2 cells diminished the suppressive effects of BU on the production of pro-inflammatory mediators, like nitric oxide (NO) and its synthase NOS2, indicating the involvement of NRF2 in the anti-inflammatory effects of BU. These data collectively suggest that BU could be repurposed as a novel NRF2 activator to control inflammation and oxidative stress.
MPARN: multi-scale path attention residual network for fault diagnosis of rotating machines
Authors: Kim Hyeongmin , Park Chan Hee , Suh Chaehyun , Chae Minseok , Yoon Heonjun , Youn Byeng D
Published: April 2023

Multi-scale convolutional neural network structures consisting of parallel convolution paths with different kernel sizes have been developed to extract features from multiple temporal scales and applied for fault diagnosis of rotating machines. However, when the extracted features are used to the same extent regardless of the temporal scale inside the network, good diagnostic performance may not be guaranteed due to the influence of the features of certain temporal scale less related to faults. Considering this issue, this paper presents a novel architecture called a multi-scale path attention residual network to further enhance the feature representational ability of a multi-scale structure. Multi-scale path attention residual network adopts a path attention module after a multi-scale dilated convolution layer, assigning different weights to features from different convolution paths. In addition, the network is composed of a stacked multi-scale attention residual block structure to continuously extract meaningful multi-scale characteristics and relationships between scales. The effectiveness of the proposed method is verified by examining its application to a helical gearbox vibration dataset and a permanent magnet synchronous motor current dataset. The results show that the proposed multi-scale path attention residual network can improve the feature learning ability of the multi-scale structure and achieve better fault diagnosis performance.
Circulating IgG antibodies to periodontal bacteria and lung cancer risk in the CLUE cohorts
Authors: Ampomah Nana K , Teles Flavia , Martin Lynn M , Lu Jiayun , Koestler Devin C , Kelsey Karl T , Beck James D , Platz Elizabeth A , Michaud Dominique S
Published: April 2023

Background

Oral health is a key indicator of overall health, well-being, and quality of life. Several studies have provided new evidence about the role of oral diseases, specifically periodontitis, in generating risk for various forms of cancers, including lung, colorectal, and pancreatic cancers.

Methods

Incident lung cancer cases (n = 192) and matched controls (n = 192) were selected from participants of the CLUE I and CLUE II cohorts. Archived serum samples collected from participants in 1974 (in CLUE I) were analyzed using immunoblotting for immunoglobulin G (IgG) antibody levels to 13 bacteria of the periodontium. Associations between antibody levels and lung cancer were estimated using conditional logistic regression.

Results

Most of the periodontal bacterial antibodies measured were inversely associated with lung cancer risk; of these, 3 were statistically significant (Prevotellaintermedia, Actinomyces naeslundii, and Veillonella parvula). A statistically significant positive association was observed for one of the Porphyromonas gingivalis strains after adjusting for P. intermedia. The sum of the logarithm of antibodies against the 13 measured bacteria was inversely associated with risk of lung cancer when the analysis was restricted to a longer follow-up (31-44 years after blood collection, highest vs lowest quartile: odds ratio = 0.26, 95% confidence interval = 0.08 to 0.84).

Conclusions

Findings from this study highlight the complexity of using serum IgG antibodies to periodontal bacteria to identify associations between oral pathogens and risk of lung cancer. The inverse associations observed for antibodies to periodontal bacteria suggest that these may represent markers of immunity that provide some advantage in reducing the development of lung cancer.
The Role of Incremental and Superficial Processing in the Depth Charge Illusion: Experimental and Modeling Evidence
Authors: Paape Dario
Published: April 2023

The depth charge illusion occurs when compositionally incongruous sentences such as No detail is too unimportant to be left out are assigned plausible non-compositional meanings (Don’t leave out details). Results of two online reading and judgment experiments show that moving the incongruous degree phrase to the beginning of the sentence in German (lit. “Too unimportant to be left out is surely no detail”) results in an attenuation of this semantic illusion, implying a role for incremental processing. Two further experiments show that readers cannot consistently turn the communicated meaning of depth charge sentences into its opposite, and that acceptability varies greatly between sentences and subjects, which is consistent with superficial interpretation. A meta-analytic fit of the Wiener diffusion model to data from six experiments shows that world knowledge is a systematic driver of the illusion, leading to stable acceptability judgments. Other variables, such as sentiment polarity, influence subjects’ depth of processing. Overall, the results shed new light on the role of superficial processing on the one hand and of communicative competence on the other hand in creating the depth charge illusion. I conclude that the depth charge illusion combines aspects of being a persistent processing “bug” with aspects of being a beneficial communicative “feature”, making it a fascinating object of study.
A giant metanephric adenoma in a young male
Authors: Mremi Alex , Bodganowics Jack , Sadiq Adnan , Tadayo Joshua , Lodhia Jay
Published: April 2023

Metanephric adenoma is an uncommon renal tumor with almost exclusively benign behavior, which can clinically and radiologically imitate malignancy. The histological examination is therefore crucial in diagnosis. Herein, we report a case of an 18-year-old male with a huge left renal mass. Histopathology and immunohistochemistry of nephrectomy resection specimen confirmed it to be metanephric adenoma. We present our experience with this rare tumor entity and literature review with focusing on differential diagnosis.
Menstrual cycle–driven vs noncyclical daily changes in sexual desire
Authors: Kiesner Jeff , Bittoni Celeste , Eisenlohr-Moul Tory , Komisaruk Barry , Pastore Massimiliano
Published: April 2023

Background

Past research on the association between sexual desire and the menstrual cycle has provided inconclusive results and has not considered the potential influence of psychological and physical changes that are frequently associated with the menstrual cycle.

Aim

To test the strength of association between the menstrual cycle (and associated symptoms) and changes in sexual desire.

Methods

Prospective daily reports across 2 full menstrual cycles (2 months) from a sample of female university students (n = 213), were analysed. Analyses tested for average effects of the menstrual cycle on sexual desire, individual differences in these effects, and cyclical and noncyclical associations between sexual desire and the 9 menstrual cycle–related changes. Note that data presented in the current article come from a larger study from which other reports have been published.

Outcomes

Target variables were (1) daily change in sexual desire and (2) daily reports of 5 psychological changes and 4 physical changes that are commonly associated with the menstrual cycle.

Results

Results showed that when considering average effects across participants, the menstrual cycle was associated with a small midcycle increase in sexual desire. However, multilevel analyses showed large individual differences in how the menstrual cycle influences sexual desire. Specifically, some participants showed a midcycle increase, others a perimenstrual increase, and others no change across the menstrual cycle. Moreover, results demonstrated that psychological changes were more important for predicting sexual desire as compared with physical changes.

Clinical Implications

These results suggest that daily measurement of sexual desire across multiple menstrual cycles may be an important tool in the assessment of sexual desire among some females.

Strengths and Limitations

Strengths of this study are the daily assessment of sexual desire and all symptoms for 2 menstrual cycles and multilevel analyses that allow the study of individual differences. Limitations include limited measurement of sexual desire based on only 2 questions and the lack of measures of relationship status and sexual orientation.

Conclusion

Emphasis is placed on the need to apply more rigorous research methods and to abandon simplistic average-effects models that are based on outdated theories and stereotypes.
Genetic susceptibility to cognitive decline following craniospinal irradiation for pediatric central nervous system tumors
Authors: Brown Austin L , Sok Pagna , Raghubar Kimberly P , Lupo Philip J , Richard Melissa A , Morrison Alanna C , Yang Jun J , Stewart Clinton F , Okcu Mehmet Fatih , Chintagumpala Murali M , Gajjar Amar , Kahalley Lisa S , Conklin Heather , Scheurer Michael E
Published: April 2023

Background

Survivors of pediatric central nervous system (CNS) tumors treated with craniospinal irradiation (CSI) exhibit long-term cognitive difficulties. Goals of this study were to evaluate longitudinal effects of candidate and novel genetic variants on cognitive decline following CSI.

Methods

Intelligence quotient (IQ), working memory (WM), and processing speed (PS) were longitudinally collected from patients treated with CSI (n = 241). Genotype-by-time interactions were evaluated using mixed-effects linear regression to identify common variants (minor allele frequency > 1%) associated with cognitive performance change. Novel variants associated with cognitive decline (P < 5 × 10−5) in individuals of European ancestry (n = 163) were considered replicated if they demonstrated consistent genotype-by-time interactions (P < .05) in individuals of non-European ancestries (n = 78) and achieved genome-wide statistical significance (P < 5 × 10−8) in a meta-analysis across ancestry groups.

Results

Participants were mostly males (65%) diagnosed with embryonal tumors (98%) at a median age of 8.3 years. Overall, 1150 neurocognitive evaluations were obtained (median = 5, range: 2–10 per participant). One of the five loci previously associated with cognitive outcomes in pediatric CNS tumors survivors demonstrated significant time-dependent IQ declines (PPARA rs6008197, P = .004). Two variants associated with IQ in the general population were associated with declines in IQ after Bonferroni correction (rs9348721, P = 1.7 × 10−5; rs31771, P = 7.8 × 10−4). In genome-wide analyses, we identified novel loci associated with accelerated declines in IQ (rs116595313, meta-P = 9.4 × 10−9), WM (rs17774009, meta-P = 4.2 × 10−9), and PS (rs77467524, meta-P = 1.5 × 10−8; rs17630683, meta-P = 2.0 × 10−8; rs73249323, meta-P = 3.1 × 10−8).

Conclusions

Inherited genetic variants involved in baseline cognitive functioning and novel susceptibility loci jointly influence the degree of treatment-associated cognitive decline in pediatric CNS tumor survivors.
A single-institution retrospective analysis of pathologically determined malignant transformation in IDH mutant glioma patients
Authors: Liu Vicki , Wetzel Ethan A , Eldred Blaine S C , Zapanta Rinonos Serendipity , Prins Terry J , Khanlou Negar , Liau Linda M , Chong Robert , Nghiemphu Phioanh L , Cloughesy Timothy F , Ellingson Benjamin M , Lai Albert
Published: April 2023

Background

Lower-grade IDH mutant glioma patients frequently undergo malignant transformation (MT), with apparent worse prognosis. Many studies examine MT in mixed IDH status cohorts and define MT using imaging, not histopathology. Our study examines the timing, predictors, and prognostic implications of pathologically determined MT in a large, exclusively IDH mutant cohort.

Methods

We identified 193 IDH mutant lower-grade glioma patients at UCLA who received multiple surgeries. We examined the outcomes of pathologically determined MT patients.

Results

Time to MT is longer in grade 2 oligodendroglioma (G2 Oligo) than in grade 2 astrocytoma (G2 Astro) (HR = 0.46, P = .0007). The grade 3 astrocytoma (G3 Astro) to grade 4 astrocytoma (G4 Astro) interval is shorter in stepwise MT (G2 to G3 to G4 Astro) patients than in initial G3 Astro patients (P = .03). Novel contrast enhancement had 65% positive predictivity, 67% negative predictivity, 75% sensitivity, and 55% specificity in indicating pathologically defined MT. In G2 Astro, initial gross total resection delayed MT (HR = 0.50, P = .02) and predicted better overall survival (OS) (HR = 0.34, P = .009). In G2 Oligo, spontaneous MT occurred earlier than treated MT (HR = 11.43, P = .0002), but treatment did not predict improved OS (P = .8). MT patients (n = 126) exhibited worse OS than non-MT patients (n = 67) in All (HR = 2.54, P = .0009) and G2 Astro (HR = 4.26, P = .02).

Conclusion

Our study expands the understanding of MT to improve IDH mutant lower-grade glioma management.
The brain-penetrant cell-cycle inhibitor p28 sensitizes brain metastases to DNA-damaging agents
Authors: Mander Sunam , Gorman Gregory S , Coward Lori U , Christov Konstantin , Green Albert , Das Gupta Tapas K , Yamada Tohru
Published: April 2023

Background

Brain metastases (BMs), the most common tumors of the central nervous system, are life-threatening with a dismal prognosis. The major challenges to developing effective treatments for BMs are the limited abilities of drugs to target tumors and to cross the blood-brain barrier (BBB). We aimed to investigate the efficacy of our therapeutic approach against BMs in mouse models that recapitulate the clinical manifestations of BMs.

Methods

BMs mouse models were constructed by injecting human breast, lung cancer, and melanoma intracardially, which allowed the BBB to remain intact. We investigated the ability of the cell-penetrating peptide p28 to cross the BBB in an in vitro 3D model and in the BMs animal models. The therapeutic effects of p28 in combination with DNA-damaging agents (radiation and temozolomide) on BMs were also evaluated.

Results

p28 crossed the intact BBB more efficiently than the standard chemotherapeutic agent, temozolomide. Upon crossing the BBB, p28 localized preferentially to tumor lesions and enhanced the efficacy of DNA-damaging agents by activating the p53-p21 axis. In the BMs animal models, radiation in combination with p28 significantly reduced the tumor burden of BMs.

Conclusions

The cell-cycle inhibitor p28 can cross the BBB localize to tumor lesions in the brain and enhance the inhibitory effects of DNA-damaging agents on BMs, suggesting the potential therapeutic benefits of this molecule in BMs.
Longer-term structural transitions and short-term macroeconomic adjustment: quantitative implications for the global financial system
Authors: McKibbin Warwick , Vines David
Published: April 2023

This paper provides quantitative modelling of the effect of three longer-term global transitions: the global demographic transition involving a marked reduction in population growth; a long-term slowdown in productivity growth which may continue, or may conceivably be reversed; and the disruption in the global economy due to increasing climate shocks and the implementation of climate policies that will be needed to reach net-zero emissions by 2050. We study the global investment needs to which these transitions will lead. We demonstrate that these investment needs will be both asymmetric across countries and over time. This asymmetry will lead to potentially large changes in trade flows and significant financial capital flows across national borders, and also to substantial real exchange changes and interest rate movements. The resulting large movements in international capital flows will have significant implications for the global financial system, which we demonstrate at the country and regional level.
The IMF’s journey on capital controls: what is the destination?
Authors: Ostry Jonathan D
Published: April 2023

The International Monetary Fund’s Articles of Agreement give countries wide latitude to regulate cross-border capital movements, subject mainly to the proviso that such regulations not be used to manipulate the exchange rate for the purpose of gaining an unfair competitive advantage. Beginning from the 1990s, however, the IMF has seemed far more supportive of fully open capital accounts than its legal framework. This can be seen not only in the institutional push to amend the Articles to enshrine fully open capital accounts in the mid-1990s, but also in subsequent speeches by IMF managing directors impugning capital controls and recent attempts to codify a set of highly restrictive circumstances under which countries may avail themselves of external financial regulations. This history suggests that, institutionally, the IMF would be far more comfortable with an architecture in which countries (strive to) eliminate restrictions on cross-border capital movements than with the vision of capital controls enshrined in its constitution by the IMF’s founding fathers, Keynes and White.
Development finance cooperation amidst great power competition: what role for the World Bank?
Authors: Morris Scott
Published: April 2023

The World Bank today faces parallel challenges to its operations and governance. The institution has since its founding provided financing on favourable terms to developing country governments to support national development efforts. Alongside these country demands, there are now calls for a new set of mandates and activities associated with global public goods. Advocates would have the Bank allocate large sums toward climate mitigation, pandemic response and preparedness, and other activities that may or may not align with national priorities in developing countries. The ability of the World Bank to strike an appropriate balance between country demands and global goods depends on the institution’s shareholders. Yet, the deterioration in the bilateral relationship between the United States and China now threatens to undermine effective governance at the institution. This paper considers the challenge of competing demands on World Bank resources and the degree to which a resolution could depend on an agreement between the United States and China, one that sets the strategic direction of the institution and addresses the growing impasse on the question of China’s shareholding in the Bank.
Fifty years on: what the Bretton Woods System can teach us about global macroeconomic policy-making
Authors: Subacchi Paola , Vines David
Published: April 2023

This paper first describes the Bretton Woods system: its origin, what it was meant to achieve, and why it collapsed. We then describe the emergence of the global non-system in which inflation targeting has replaced full-employment Keynesianism and floating exchange rates have replaced the Bretton Woods set-up of fixed but adjustable exchange rates. We describe how the Bretton Woods system set about achieving the three objectives laid down for a well-functioning international economic system by John Maynard Keynes: full employment without inflation, sustainable current account balances between countries, and a sustainable flow of international financial capital—on the understanding that an open trading regime is also fostered. Because the global non-system is now very different from the Bretton Woods system, Keynes’s objectives now need to be achieved in a very different manner. Looking forward, this non-system faces a number of longer-term challenges. Important adjustment issues will arise in relation to the global demographic transition; the potential long-term slowdown in productivity growth; and the rise in investment in renewable sources of energy which will be necessary to help ensure that the world is able to move towards zero emissions of carbon by 2050. We also discuss important policy issues in relation to the flows of international capital to emerging market economies, and the likely need for a sovereign debt reconstruction mechanism. We then go on to consider two significant structural changes to the world—the emergence of the European Monetary Union and the rise of China. A final section of the paper considers the importance of leadership in this global non-system.
From the Bretton Woods system to the global non-system: the trials and tribulations of slow learning
Authors: Vines David , Subacchi Paola
Published: April 2023

In this paper we analyse why an understanding of the global ‘non-system’, in which we now live, took so long to arrive after the Bretton Woods system collapsed in 1971. We first describe how knowledge of how an inflation-targeting regime would operate—what we call ‘Taylor-rule macroeconomics’—was only gradually created during the 1970s, 1980s, and 1990s. We then describe how, subsequent to this, an awareness emerged, also gradually, of how the international non-system might work, depending, as it does, on Taylor-rule macroeconomics being already in place. We then discuss the Great Moderation, making clear that a well-functioning global non-system would require not just inflation targeting and floating exchange rates in each country, but also adequate fiscal discipline, and a satisfactory form of financial regulation. We describe how a well-functioning version of this global non-system would actually fit together. We then discuss how this non-system has responded to two enormous challenges of the last 15 years, namely the Global Financial Crisis and the Covid pandemic. This discussion of what has happened in the recent past provides the background to a discussion, in the companion paper by Subacchi and Vines in this issue of the Oxford Review of Economic Policy, of the challenges that the global non-system will face in the future.