bluuebunny/crossref_metadata_2025 huggingface dataset:
Odontoma composto associado canino incluso no palato: relato de caso
Authors: Fernandes Breno dos Reis , Marchiori Darah Ligia , Medronho Daniel de Lima e Sá , Mulinari-Santos Gabriel , Figueira Patrick Peloso Pereira , Hadad Henrique , Escudeiro Emmanuel Pereira , Silva Jonathan Ribeiro da
Published: June 2020

Odontoma refere-se a tumores de origem odontogênica. Sua etiologia envolve distúrbios de desenvolvimento, traumatismos e infecções. Embora o crescimento seja lento e geralmente assintomático, complicações de ordem estética e funcional podem advir da permanência desta lesão. Os odontomas podem ser classificados como complexos e compostos, e o seu tratamento envolve a remoção cirúrgica conservadora com posterior exame histopatológico. Neste artigo é relatado um caso clínico de uma remoção de um canino incluso no palato associado a um odontoma com posterior enxertia utilizando enxerto do ramo mandibular particulado.Descritores: Odontoma; Cirurgia Bucal; Dente Canino.ReferênciasTeruhisa U, Murakami J, Hitasomi M, Yanagi Y, Asaumi J. A case of unerupted lower primary second molar associated with compound odontoma. Open Dent J. 2009;3:173-76.Ladeinde AL, Ajayi OF, Ogunlewe MO, Adeyemo WL, Arotiba GT, Bamgbose BO et al. Odontogenic tumors: a review of 319 cases in a Nigerian teaching hospital. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99(2):191-95.Hidalgo-Sánchez O, Leco-Berrocal MI, Martínez-Gonzáles JM. Metaanalysis of the epidemiology and clinical manifestations of odontomas. Med Oral Patol Oral Cir Bucal. 2008;13(11):730-34.Pires LD, Krüger MLB, Viana ES, Kramer PF, Ferreira SL. Odontoma: estado da arte e relato de caso clínico. Stomatos. 2007;13(24):21-9.Chang JY, Wang JT, Wang YP, Liu BY, Sun A, Chiang CP. Odontoma: a clinicopathologic study of 81 cases. J Formos Med Assoc. 2003;102(12):876-82.Hisatomi M, Asaumi JI, Konouchi H, Honda Y, Wakasa T, Kishi K. A case of complex odontoma associated with an impacted lower deciduous second molar and analysis of the 107 odontomas. Oral Dis. 2002;8(2):100-5.Sheehy EC, Odell EW, Al-Jaddir G. Odontomas in the primary dentition: literature review and case report. J Dent Child (Chic). 2004;71(1):73-6.Sasaki PS, Biancalana H, Duarte DA. Odontoma em pacientes odontopediátricos: repercussöes clínicas e proposiçäo de tratamento Rev Assoc Paul Cir Dent. 2002;56(5):382-86.Serra-Serra G, Berini-Aytés L, Gay-Escoda C. Erupted odontomas: a report of three cases and review of the literature. Med Oral Patol Oral Cir Bucal. 2009;14(6):299-303.Cardoso LC, Miyahara GI, Magro Filho O, Garcia Junior IR, Soubhia AMP. Odontoma combinado associado a dentes não-irrompidos: relato de casos clínicos. Rev Odontol Araçatuba. 2003;24:47-51.Lukes SM, Wachter KM. Compound odontoma: a case study. J Dent Hyg. 2003;77(1):47-9.Chrcanovic RB, Jaeger F, Freire-Maya B. Two-stage surgical removal of large complex odontoma. Oral Maxillofac Surg. 2010;14(4):247-52.
Atenção odontológica ao paciente com carcinoma epidermoide em palato mole
Authors: Patrocinio Victor Hugo , Nascimento Paulo Pereira do , Silva Edilma  Moraes da , Peruffo Leticia Bandeira , Patrocinio Aline Almeida da Motta , Oliveira Renata Lanzoni de , Gaetti Jardim Ellen Cristina
Published: June 2020

O Carcinoma Epidermóide enquadra-se como uma das neoplasias malignas mais comuns em região de orofaringe acontecendo sobretudo em pacientes leucodermas do sexo masculino e maiores de 50 anos de idade sendo o alcool e o fumo os fatores mais associados ao surgimento da patologia. Deste modo, é objetivo mencionar o tratamento cirúrgico de paciente com tumor de orofaringe levando em consideração a necessidade do enfoque odontológico. O caso evidencia a importância do diagnóstico precoce  atrelado ao atendimento odontológico inicial de lesões precursoras do câncer oral alem da necessidade de prover ao paciente manutenção das funções mastigatórias.Descritores: Carcinoma de Células Escamosas; Assistência Odontológica; Palato Mole.ReferênciasFrancio FF, Salum FG, Cherubini K, Soares LY, Figueiredo MAS. Perfil epidemiológico de portadores de carcinoma bucal do serviço de estomatologia hsl-PUCRS. Rev Odontol. Bras Central. 2011;20(55):308-312.Neville BW, Damm DD, Alen CM, Bouquot JE.  Patologia oral e maxilofacial. Rio de Janeiro: Elsevier; 2009.Freitas DA, Caballero AD, Pereira MM, Oliveira SKM, Silva GPE, Hernandez CIV. Oral sequelae of head and neck radiotherapy. Rev CEFAC. 2011;13(6):1103-08.Araujo TLC, Mesquita LKM, Vitorino RM, Macedo AKMN, Amaral RC, Silva TF. Manifestações bucais em pacientes submetidos a tratamento quimioterápico. Rev Cubana Estomatol. 2015;52(4):16-24.Rocha-Buelvas A, Pumalpa AJ. Manejo odontológico de las complicaciones orales secundarias al tratamiento oncológico con quimioterapia y radioterapia. CES odontol. 2011;24(2):71-8.
ARSITEKTUR DAN AIR (Kasus: Kota Palembang)
Authors: Adiyanto Johannes
Published: June 2020

Title: Architecture and Water (Palembang Case)

The total area of Indonesia consists of a total land area of 1,904,569 km2 and a sea area of 7.900.000 km2. Indonesia's geographical location has two rainy and dry seasons, tropical climate and high humidity and sunshine throughout the year. This condition is also reinforced by the location of Indonesia located on two continents, Asia and Australia. Thus Indonesia is not only about land but also waters. This general description becomes the basic of understanding the case study of Palembang city. The case of Palembang was appointed to see the consequences of 'water' in the course of city development and the traces of its architectural artifacts. Then how the latest development of Palembang city, is still oriented to the water or have forgotten the water as the face of the city? The purpose of this discussion is to show the development of the city, especially Palembang, related to its natural geographical conditions. Explore this descriptive paper using a historical study approach with chronic descriptive methods. Chronic descriptive method is a method of translation as it is with a note on events that are considered important in a particular location. Descriptive descriptive results show that the city of Palembang has left the water, the icon of the Musi River is placed as a 'separator / distinguishing / distance maker' rather than 'union' between Ilir and Ulu. Geographical natural conditions are not placed as a basis in the implementation and development of Palembang City.
KAJIAN ARSITEKTUR HIJAU DALAM PENGEMBANGAN DESAIN GEDUNG PEMERINTAHAN
Authors: Afrizal Zahmi
Published: June 2020

Title: Green Architecture Study in The Development of Government Building Designs

The development of constructing the building especially the government building develop rapidly and increasing the number of needs in each region or province in Indonesia. Issues concerning environmental problems resulting from the impact of the development of government buildings in Indonesia at this time such as environmental degradation, global warming, energy and water crises into the background of the emergence of the concept of green architecture or environmentally friendly architecture. The components of green architecture within the building and its environment relate to the site management, energy efficiency, water use efficiency, indoor air quality, environmentally friendly materials, waste management, wastewater management, and vegetation placement are necessary to be researched. The results of this study is expected to be a reference and design guidelines on the development of government buildings in Indonesia to become green buildings that are environmentally friendly.
MENYEMAIKAN KEMAMPUAN MELIHAT DENGAN HATI BAGI MAHASISWA ARSITEKTUR
Authors: Octavia Linda , Prawoto Eko
Published: June 2020

Title: Developing Mindful Eyes of the Architecture Students

Change is bound to happen in nature, be it revolutionary or evolutionary. The fundamental changes that occur throughtout all aspects would consequently have an impact on life in its entirety, and architecture education is no exception. Hence, architecture education should also continue to refine itself to anticipate the substantial issues it encounters. This first year studio is one of the concepts of change in architecture education, namely by attempting to find a different foundation wherein the emphasis of education is not in the accumulation of information but in fostering individuals to acquire sensitivity and skills for contemplating through a perspective of mutual togetherness. Mindful eyes is actually the consciousness to see, to learn through one?s eyes with awareness, which is implemented in this first year studio with the objective of learning to recognize the tools that will be used in the subsequent studios in the following years to come. This paper is the response of architecture education in confronting changes and it is currently implemented on first year architecture students. Several samples of first year student tasks are presented in a very simple manner, it is, however, aimed at preparing future architects with several essential skills.
PERANCANGAN ALAT BANTU MEMBILAS PAKAIAN DENGAN PENDEKATAN DESAIN INKLUSIF UNTUK MENGURANGI RISIKO CARPAL TUNNEL SYNDROME
Authors: Anggia Gabriella Nadya , Guspara Winta Adhitia , Nur Christmastuti
Published: June 2020

Title: Design of Rinsing Clothes Tools with Inclusive Design Approach to Reduce Carpal Tunnel Syndrome Risk

Based on case studies at Panti Wreda Perandan Padudan, Gondokusuman, Yogyakarta, the fact that the clothes that are washed by the elderly is not completely clean. One clean indicator of the laundry is seen from the absence of detergent foam that makes the water become cloudy when rinsing clothes. Manual rinsing process requires the work of both hands that seek friction and pressure (i.e. to rubben) so that the soap water contained in the fabric can come out. The movement of the evaporating on rinsing has a tendency to inflict numbness even pain (i.e. carpal tunnel syndrome) if done at high intensity. The condition can deteriorate in long-lasting routines in the elderly. In the process of cassing, the elderly have limited hand grips in conducting activities that are made repeatedly. With this problem, it is necessary to design the tools to rinse the clothes so as to minimize the foam attached to the clothes until the result of a cleaner laundry and can reduce the risk of carpal tunnel syndrome. The design of this product utilizes a two-stage inclusion approach, which is research and design designing. The research phase uses ergonomics- based methods with observation and interview techniques. The design process that was used after obtaining the designs statement was SCAMPER. Through this method, the tool is produced to rinse the laundry cleaner without experiencing the pain in the hands.
KAJIAN PERUBAHAN RUANG DAN SOUNDMARK KAWASAN WISATA PUSAKA TAMANSARI YOGYAKARTA
Authors: Noviandri Patricia Pahlevi , Sabono Ferdy
Published: June 2020

Title: Study of Space Changing and Soundmark in Tamansari Heritage Tourism Area, Yogyakarta

Tamansari area is an area of historical value. Until now, this region has been conserved and used as a heritage tourism. The Tamansari site, which has not been used anymore since the reign of Sultan Hamengkubuwono III, has caused the growth of residential areas around it. This causes a change in the solid void of the Tamansari area. Changes in the existing building structure create differences in the soundscape of the area that was once the location of the palace retreat and is now a heritage tourism area. In this study will discuss the changes that occur in the mass management of buildings in the Tamansari area that will affect the environmental acoustics of the area. This research method uses qualitative deductive method by comparing the shape of the space during the active period of the building as the resting of the Keraton family with the current building mass discussed with the theory of space and acoustic environment. The results of this study are changes in ground figures and linkages showing changes in the soundmark of the Tamansari area. Changing ground figures make the impact of increasingly diverse activities appear. Soundmark changed from the dominant calm voice to the nois dominant. The soundmark area changes from sounds that support a sacred atmosphere with sounds that are due to building density. This change in soundmark creates a change of sense of place from the Tamansari area.
KESIAPSIAGAAN DESA TERHADAP BENCANA TANAH LONGSOR
Authors: Octavia Linda , Prawoto Eko
Published: June 2020

Title: Village Preparedness Against Landslide Disaster

Disasters that have previously occurred can almost be guaranteed that they would most likely reoccur without our knowing when and where they would take place once again. Maximum preparation and understanding about what we should do during events of disaster are substantial measures that we must take. In addition, knowledge or experiences relating to disasters should also be passed down to the next generation. This study employed methods of in-depth interviews and direct observations to acquire data regarding indicators of disasters found in the village of Kebonharjo. The interviews were performed with the villagers, while observations were carried out in a number of locations where landslides had occurred. The acquired results were subsequently analyzed in order to gain an understanding of the most significant indicators that can be used as a standard for the villagers to be prepared in the event of a disaster. The availability of written knowledge and documentation pertaining to these indicators will consequently lead to such knowledge being more widely known by the community and they can also serve as a useful resource for the villagers when they find locations that are considered to show indications of disaster, in which they can then make a quick identification of the situation. Transforming oral knowledge into a written one is admittedly an appropriate choice in order to strengthen the village’s preparedness against disaster.
PENGEMBANGAN DESAIN GANTUNGAN PAKAIAN INKLUSIF UNTUK MEMUDAHKAN AKTIVITAS MENJEMUR PAKAIAN
Authors: Angelika Amelia , Guspara Winta Adhitia , Nur Christmastuti
Published: June 2020

Title: Development of Inclusive Hanger Design to Facilitate Clothes Drying Activities

Laundry activities, including drying are still recommended to be done by the elderly independently. However, the decline in the physical condition of the elderly, including a decrease in the balance of body position, cannot be avoided. In the observation at the GKJ Gondokusuman nursing home, the drying place is uses a rope on the roof or pole that is quite high from the reach of the elderly hand. When drying clothes, the elderly must stretch their arms and tiptoe because of the differences in height of the clothesline. This condition can increase the risk of accidents for the elderly who lose balance. This study aims to develop a product to dry the laundry and reduce the distance between the users with a high clothesline. This product development was using design research and product design. The research method was based in ergonomics knowledge through an inclusive design approach. The techniques used were behavioral observation, assessment of body activities, like Nordic Body Map (NBM) and Rapid Entire Body Assignment (REBA). The results of the NBM stated that the elderly experienced pain in the right side of the body, while the results of the REBA assessment showed a score of 10. This condition showed that the elderly posture while drying still had a high risk of injury. As the results of these studies, the product is designed with a function to hang laundry that make user's body position more balanced because there is no need to stretch arms and tiptoe too high. Users also easily put clothes on the hanger because there is a grip feature for both hands.
Restoring and Controlling the Water Pollution of Endangered River in Bangladesh: A Case Study in Pabna City
Authors: Sadath Abu , Afroz Farhana , Ara Hosne , Kafy Abdulla-Al
Published: June 2020

Rivers are the lifeline of Bangladesh economy and serve as the source of water supply, fisheries, irrigation for agriculture, low-cost transport, generate electricity and conserve biodiversity. The Ichamati River situated in Pabna, Bangladesh is also a blessing for the city. However, recently, due to the irregular and unplanned activities adjacent to the riverside, the life, flow and water quality of the river is in a vulnerable condition. This study aims to identify the present status of the Ichamati River and provide an effective design approach and policy measures in restoring the river flow and control water pollution. The data was collected from the questioner surveys, key informant interviews and focus group discussions. Results suggest that several factors such as the construction of an illegal settlement, unplanned waste dumping, disposal of fiscal sludge through sewerage connection, lack of awareness among people regarding the importance of river biodiversity and absence of riverfront development and conservation plan are responsible for water pollution, inconsistent water flow and damaging the life cycle of Ichamati river. The design approach and policy measures were developed based on the perceptions of local community people, experts and government officials. The suggested policy measures will help to restore the flow of the river and reduce the water pollution, and the design approach will ensure the economic benefit of the riverfront development in future.
Waste load allocation under uncertainty using game theory approach and simulation-optimization process
Authors: Andik Behnam , Niksokhan Mohammad Hossein
Published: June 2020

This article aims to present a new methodology for waste load allocation (WLA) in a riverine system considering the uncertainty and achieve the lowest amount of inequity index, cost, and fuzzy risk of standard violation. To find a surface of undominated solutions, a new modified PAWN method, initially designed for sensitivity analysis, was developed and coupled with a simulation-optimization process using multi-objective particle swarm optimization (MOPSO) algorithm, to consider the uncertainty of all affecting variables and parameters by using their probability distribution. The proposed methodology applied to Sefidrood River in the northern part of Iran. Graph model for conflict resolution (GMCR) as a subset of game theory was implemented to attain a compromise on WLA among the stakeholders of a river system's quality in Iran: Department of Environment, Municipal Waste Water, and Private Sector. Some undominated solutions were used in GMCR model and modeling the conflict among decision makers reveals that their preferences and the status quo do not lead to a solely stable equilibrium; thus the intervention of a ruler as arbitrator leads them to reach a compromise on a scenario that has a median FRVS and cost. Sensitivity analysis was done using the PAWN method to assess the sensitivity of three intended objectives to all variables and parameters.
Assessing the impacts of climate change on aerobic rice production using the DSSAT-CERES-Rice model
Authors: Alejo Lanie A.
Published: June 2020

This study assessed the impacts of climate change on aerobic rice production using the DSSAT-CERES-Rice model. Actual data observed from four cropping seasons in two sites were used for calibration and validation. Four Representative Concentration Pathway scenarios were used to simulate climate change. The optimum planting windows were simulated across these scenarios. Results showed that DSSAT-CERES-Rice could adequately simulate aerobic rice production. Changes in seasonal rainfall and increases in temperature especially during dry seasons adversely affected aerobic rice production. Reduction of rainfall during the wet seasons favored aerobic rice production. Yield losses are twice as large as gains. Changes in climate could cause yield improvements to decline from 83% to 53% and yield reductions to increase from 150% to 177% towards the end of the 21st century. Selecting the best planting windows could optimize production to avoid huge economic losses. Optimum planting windows were simulated during normal, dry, and wet climate conditions. The derived set of genetic coefficients could be used to assess various aerobic rice farm crop and nutrient management strategies as well as other climate and soil conditions. The long-term projections on aerobic rice production could guide policy and decision-makers on designing long-term climate change adaptation and mitigation plans and programs.
Advancing the Therapeutic Efficacy of Bioactive Molecules by Delivery Vehicle Platforms
Authors: Tsiailanis Antonis D. , Tzakos Andreas G. , Mavromoustakos Thomas
Published: June 2020

Drugs have to overcome numerous barriers to reach their desired therapeutic targets.
In several cases, drugs, especially the highly lipophilic molecules, suffer from low solubility
and bioavailability and therefore their desired targeting is hampered. In addition, undesired
metabolic products might be produced or off-targets could be recognized. Along these
lines, nanopharmacology has provided new technological platforms, to overcome these
boundaries. Specifically, numerous vehicle platforms such as cyclodextrins and calixarenes
have been widely utilized to host lipophilic drugs such as antagonists of the angiotensin II
AT1 receptor (AT1R), as well as quercetin and silibinin. The encapsulation of these drugs in
supramolecules or other systems refines their solubility and metabolic stability, increases their
selectivity and therefore decreases their effective dose and improves their therapeutic index.
In this mini review we report on the formulations of silibinin and AT1R antagonist candesartan
in a 2-HP-β-cyclodextrin host molecule, which displayed enhanced cytotoxicity and increased
silibinin’s and candesartan’s stability, respectively. Moreover, we describe the encapsulation
of quercetin in gold nanoparticles bearing a calixarene supramolecular host. Also, the
encapsulation of temozolomide in a calixarene nanocapsule has been described. Finally, we
report on the activity enhancement that has been achieved upon using these formulations as
well as the analytical and computational methods we used to characterize these formulations
and explore the molecular interactions between the host and quest molecules.
A Systems Biology Approach for miRNA-mRNA Expression Patterns Analysis in Rheumatoid Arthritis
Authors: Tavasolian Fataneh , Hosseini Ahmad Zavaran , Soudi Sara , Naderi Mahmood , Sahebkar Amirhossein
Published: June 2020

Objective:

Considering the molecular complexity and heterogeneity of rheumatoid
arthritis (RA), the identification of novel molecular contributors involved in RA initiation and
progression using systems biology approaches will open up potential therapeutic strategies. The
bioinformatics method allows the detection of associated miRNA-mRNA as both therapeutic and
prognostic targets for RA.

Methods:

This research used a system biology approach based on a systematic re-analysis of the
RA-related microarray datasets in the NCBI Gene Expression Omnibus (GEO) database to find out
deregulated miRNAs. We then studied the deregulated miRNA-mRNA using Enrichr and
Molecular Signatures Database (MSigDB) to identify novel RA-related markers followed by an
overview of miRNA-mRNA interaction networks and RA-related pathways.

Results:

This research mainly focused on mRNA and miRNA interactions in all tissues and
blood/serum associated with RA to obtain a comprehensive knowledge of RA. Recent systems
biology approach analyzed seven independent studies and presented important RA-related
deregulated miRNAs (miR-145-5p, miR-146a-5p, miR-155-5p, miR-15a-5p, miR-29c-3p, miR-
103a-3p, miR-125a-5p, miR-125b-5p, miR-218); upregulation of miR-125b is shown in the study
(GSE71600). While the findings of the Enrichr showed cytokine and vitamin D receptor pathways
and inflammatory pathways. Further analysis revealed a negative correlation between the vitamin
D receptor (VDR) and miR-125b in RA-associated gene expression.

Conclusion:

Since vitamin D is capable of regulating the immune homeostasis and decreasing the
autoimmune process through its receptor (VDR), it is regarded as a potential target for RA.
According to the results obtained, a comparative correlation between negative expression of the
vitamin D receptor (VDR) and miR-125b was suggested in RA. The increasing miR-125b
expression would reduce the VitD uptake through its receptor.
Chitin, Characteristic, Sources, and Biomedical Application
Authors: Shahbaz Umar
Published: June 2020

Background:

Chitin stands at second, after cellulose, as the most abundant polysaccharide
in the world. Chitin is found naturally in marine environments as it is a crucial structural component of
various marine organisms.

Methods:

Different amounts of waste chitin and chitosan can be discovered in the environment. Chitinase
producing microbes help to hydrolyze chitin waste to play an essential function for the removal of chitin
pollution in the Marine Atmosphere. Chitin can be converted by using chemical and biological methods
into prominent derivate chitosan. Numerous bacteria naturally have chitin degrading ability.

Results:

Chitin shows promise in terms of biocompatibility, low toxicity, complete biodegradability,
nontoxicity, and film-forming capability. The application of these polymers in the different sectors of
biomedical, food, agriculture, cosmetics, pharmaceuticals could be lucrative. Moreover, the most recent
achievement in nanotechnology is based on chitin and chitosan-based materials.

Conclusion:

In this review, we examine chitin in terms of its natural sources and different extraction
methods, chitinase producing microbes and chitin, chitosan together with its derivatives for use in biomedical
and agricultural applications.
Drug Delivery Assessment of a Novel Triple Antibiotic-Eluting Injectable Platelet-Rich Fibrin Scaffold: An In Vitro Study
Authors: Rafiee Azade , Memarpour Mahtab , Taghvamanesh Sara , Karami Forough , Karami Somayeh , Morowvat Mohammad H.
Published: June 2020

Background:

Intracanal disinfection is a critical, yet challenging goal for long-term success
in regenerative-based treatments. This in-vitro study aimed to assess the release profile of triple antibiotic-
eluting Injectable Platelet-Rich Fibrin (I-PRF) constructs in 28 days.

Methods:

I-PRF scaffolds containing triple antibiotic mixture [Metronidazole (MET), Ciprofloxacin
(CIP), and Minocycline (MINO)] by immersion (group one), I-PRF scaffolds containing triple antibiotic
mixture by integration (group two), and antibiotic-free I-PRF scaffolds (group three) were fabricated.
The antibiotic release from the scaffolds was measured using High-Performance Liquid Chromatography
(HPLC) (the mobile phase of 0.1% formic acid and methanol (35:65 v/v), a C18 analytical
column (150 × 4.6 mm, 5 μm) at a flow rate of 0.7 mL/min, at 25ºC) at days 1, 3, 7, 14, 21, and 28.

Results:

Retention times for MINO, CIP, and MET were achieved as 2.3, 2.6, and 3.1 min, respectively.
The maximum UV absorbance values for CIP, MET, and MINO were 268 nm, 278 nm, and 350
nm, respectively. The results of the first group showed burst release within the first 24 hours followed
by sustained maintenance of all three antibiotics up to 14 days. MINO and MET were still detectable in
the third week. The second group could not sustainably release the antibiotics.

Conclusions:

The developed method for the simultaneous identification and quantification of each antibiotic
in I-PRF was sensitive and quick. Overall, group one could take up the antibiotics in adequate
quantities and then subsequently release them over the study period.
Unveiling the Biodiversity of Hyperthermophilic Archaea in Jharia Coal Mines: Potential Threat to Methanogenesis?
Authors: Jha Priyanka , Singh Joginder , Vidyarthi Ambarish S. , Prasad Ram
Published: June 2020

Aim:

To examine the biodiversity of archaeal sulfate reducers and methanogens present in
the underground coal mines of Jharia using metagenomics and pyrosequencing.

Objectives:

1) Bioinformatical analysis of the metagenomic data related to a taxonomic analysis obtained
from the coal to investigate complete archaeal taxonomic features of the coal bed methane
(CBM) microbiome. 2) Bioinformatical analysis of the metagenomic data related to a functional analysis
obtained from the coal to investigate functional features relating to taxonomic diversity of the
CBM microbiome. 3) The functional attributes have been examined specifically for ORFs related to
sulfite reduction and methanogenesis.

:

The taxonomic and functional biodiversity related to euryarchaeota will help in a better understanding
of the obstacles associated with methane production imposed by the sulfate reducers.

Background:

The microbial methanogenesis in the coal microbiome is a resultant of substrate utilization
by primarily fermentative bacteria and methanogens. The present work reveals the biodiversity of
archaeal sulfate reducers and methanogens present in the underground coal mines of Jharia using metagenomics
and pyrosequencing.

Methodology:

Bioinformatical analysis for structural and functional attributes was accomplished using
MG-RAST. The structural analysis was accomplished using RefSeq database, whereas the functional
analysis was done via CoG database with a cut off value, a sequence percent identity, and sequence
alignment length cut off of 1e−5, 60% and 45, respectively.

Results:

Attained communities revealed the dominance of hyperthermophilic archaea Pyrococcus furiosus
along with Thermococcus kodakarensis in the coal metagenome.The obtained results also suggest
the presence of dissimilatory sulfite reductase and formylmethanofuran dehydrogenase, formylmethanofuran:
tetrahydromethanopterin formyltransferase involved in sulfite reduction and methanogenesis,
respectively, in the microbiome.

Conclusion:

This report is the first attempt to showcase the existence of specific euryarchaeal diversity
and their related functional attributes from Jharia coal mines through high throughput sequencing.
The study helps in developing a better understanding of the presence of indigenous microbes (archaea)
and their functions in the coal microbiome, which can be utilized further to resolve the energy crisis.
Vitamin D-RAAS Connection: An Integrative Standpoint into Cardiovascular and Neuroinflammatory Disorders
Authors: Giménez Virna Margarita Martín , Sanz Raúl Lelio , Marón Feres José Mocayar , Ferder León , Manucha Walter
Published: June 2020

Background:

The neuroinflammatory process is associated with the pathogenesis of many
cardiovascular disorders, particularly with hypertension. In this regard, the deficiency of vitamin D
seems to increase the risk of cardiovascular pathologies related to neuroinflammation. Long-term lack
of vitamin D leads to over-activation of the renin-angiotensin-aldosterone system (RAAS), one of the
essential mechanisms of blood pressure regulation.

Purpose of Review:

This review summarizes the latest studies carried out to evaluate the primary
mechanisms underlying the neuroprotective effect of vitamin D and its receptors (VDR) in the central
nervous system. Besides, the present article condenses the evidence supporting the link between vitamin
D and the RAAS in hypertension and neuroinflammation.

Highlights Standpoints:

Vitamin D deficiency is highly prevalent in the world, and the rising prevalence
of neuroinflammatory diseases and associated pathologies such as hypertension around the world
justifies the urgent need of searching new and more effective therapeutic methods that could be related
to RAAS modulation and vitamin D levels management.
Epidemiology of HIV in Iran
Authors: Najafi Zeinab , Taj Leila , Dadras Omid , Ghadimi Fatemeh , Moradmand Banafsheh , SeyedAlinaghi SeyedAhmad
Published: June 2020

:

Iran has been one of the active countries fighting against HIV/AIDS in the Middle East
during the last decades. Moreover, there is a strong push to strengthen the national health management
system concerning HIV prevention and control. In Iran, HIV disease has its unique features,
from changes in modes of transmission to improvement in treatment and care programs, which can
make it a good case for closer scrutiny. The present review describes the HIV epidemic in Iran from
the first case diagnosed until prevention among different groups at risk and co-infections. Not only
we addressed the key populations and community-based attempts to overcome HIV-related issues in
clinics, but we also elaborated on the efforts and trends in society and the actual behaviors related to
HIV/AIDS. Being located in the Middle East and North Africa (MENA) region, given the countryspecific
characteristics, and despite all the national efforts along with other countries in this region,
Iran still needs to take extra measures to reduce HIV transmission, especially in health education.
Although Iran is one of the pioneers in implementing applicable and appropriate policies in the
MENA region, including harm reduction services to reduce HIV incidence, people with substance
use disorder continue to be the majority of those living with HIV in the country. Similar to other
countries in this region, the HIV prevention and control programs aim at 90-90-90 targets to eliminate
HIV infection and reduce the transmission, especially the mother-to-child transmission and
among other key populations.
The Potential Prebiotic Effects of Yacon (Smallanthus sonchifolius) in Colorectal Cancer
Authors: Verediano Thaísa A. , Viana Mirelle L. , das G.V. Tostes Maria , Costa Neuza M.B.
Published: June 2020

Background:

Colorectal cancer is caused by genetic predisposition and lifestyle risk factors and is associated with altered homeostasis of the intestinal microbiota. Evidence suggests that chronic infection and inflammation contribute to carcinogenic mutagenesis and promote cancer initiation and progression. Food components with prebiotic properties, such as fructooligosaccharides (FOS), promote intestinal integrity and health benefits. Yacon (Smallanthus sonchifolius) is an abundant source of FOS, which are fermented by beneficial bacteria, improving the intestinal environment affected by colorectal cancer.

Objective:

In the current review, the aim was to discuss colorectal cancer and its inflammatory process of development. Also, some general aspects concerning yacon roots and its prebiotic properties are described. Finely, the beneficial effects of yacon to reduce intestinal parameters altered due to colorectal cancer are summarized.

Conclusion:

It was verified that yacon might improve immunological parameters, intestinal barrier, intestinal microbiota, and inflammation in induced colorectal cancer in animals, especially. Researches with humans must be further investigated to prove these positive effects.
Evaluation of Anti-Diabetic Potential of Corn Silk in High-Fat Diet/ Streptozotocin-Induced Type 2 Diabetes Mice Model
Authors: Sheng Li , Chen Qian , Di Lei , Li Ning
Published: June 2020

Background:

Corn silk is the elongated stigma of the female flower of Zea mays and traditionally
used to treat diabetes mellitus (DM).

Objective:

To investigate the beneficial effects of corn silk extract (CSE) on HFD/STZ-induced diabetic
C56BL/6J mice.

Methods:

Establishment of a T2DM model through feeding HFD combined with STZ. T2DM was
randomly divided into 5 groups: diabetic control mice treated with vehicle (model group, n=10), metformin-
treated group (metformin: 150 mg/kg.d, n=10), three CS-treated groups (CS: 300, 600 and
1200 mg/kg.d, n=10). After four weeks of CS treatment, the body weight, FBG, IR, TC, TG, LDL-C,
MDA and SOD levels of mice were measured. In addition, the liver tissue was histomorphologically
analyzed by HE stain followed a light microscopy observation.

Results:

4-week CSE treatment significantly reduced FBG and enhanced the glucose tolerance; improved
IR indicated by decreased HOMA-IR and elevated ISI; alleviated hyperlipidemia indicated by
decreased TC, TG, LDL-C, and increased HDL-C; reduced oxidative stress by decreased MDA and
elevated SOD activity; decreased hepatic lipid accumulation and prevented liver tissue morphological
change in T2DM. In addition, CSE treatments effectively prevent the weight gain loss of diabetic mice.

Conclusion:

These results confirmed the traditionally claimed benefits of corn silk on DM, which
suggested that the corn silk possessed the anti-diabetic potential and could be further developed as a
cheap and plant-derived agent for the treatment of type 2 diabetes mellitus.
Taxonomy of Cluster-Based Target Tracking System in Wireless Sensor Networks
Authors: Odeh Ammar
Published: June 2020

Background:

In the last decade, with the advancement of big data technology and the
internet of things, Wireless Sensor Networks (WSN) have become fundamental for the success of
a different range of applications especially those demanding massive data processing.

Objective:

This paper investigates several tracking methods to introduce a novel cluster-based target
tracking analysis model.

Methods:

Some crucial factors of the cluster-based routing protocols are demonstrated, and a
comparison among these different methods is conducted according to our taxonomy, such as cluster
formation, predicate/proactive, target speed, single or multi-object tracking, boundary problem,
scalability, energy efficiency, and communication cost. This can help the community of researchers
by providing clear information for further study.

Results and Conclusion:

The proposed paper compares the differences and similarities between
the available approaches across different categories in terms of the cluster construction, clustering
method, object speed, number of objects, boundary problem, and scalability. Finally, we can recognize
some open issues that have so far gained little attention or are unexplored yet.
Biosynthesis of Silver Nanoparticles from Synechocystis sp to be Used as a Flocculant Agent with Different Microalgae Strains
Authors: Fathy Wael , Elsayed Khaled , Essawy Ehab , Tawfik Eman , Zaki Ayman , Abdelhameed Mohamed S. , Hammouda Ola
Published: June 2020

Background:

Biofuels produced from trans-esterification of high lipid
content in microalgae represent a promising alternative renewable source of energy
to the limited and depleted global fossil fuel reservoir. The most critical step in
such a process is the harvesting of algal cells.

Objective:

We aimed to improve the current methodology for microalgae harvesting
via utilizing biosynthesized silver nanoparticles (AgNPs) from Synechocystis sp.
ElfSCS31 as an eco-friendly, stable, and affordable flocculant agent.

Methods:

AgNPs were prepared by the green synthesis method using the alcoholic
extract of Synechocystis sp. ElfSCS31. The synthesized nanoparticles were
characterized by Zeta sizer, X-ray Diffraction (XRD), Fourier Transform Infrared
Spectroscopy (FT-IR), and UV-Vis Spectroscopy. Biosynthesised AgNPs were
applied for harvesting 20 microalgae strains, and then, harvesting efficiency was
determined by UV Spectrophotometry.

Results:

Our results revealed an average size of polydispersed nanoparticles
ranging from 10 to 100 nm for prepared AgNPs and the potential of 1.78 mV, with
an average crystallite size of 22 nm. Biosynthesised AgNPs exhibited harvesting
efficiency towards different strains of microalgae, which reached 97% in some
strains as in Chlorella lobophora and Chlorococcum oleofaciens.

Conclusion:

The presented study introduces a feasible strategy using biosynthesized
AgNPs as a flocculant agent to harvest different strains of microalgae at normal
growth conditions of light and temperature. Our developed method could replace the
classical high-cost step of harvesting that leads to unravelling the full potential of
microalgae as a promising and fascinating source for biofuels production.
Hacia un mercado ecológico
Authors: Marshall Wesley
Published: June 2020

Este artículo propone la creación de una nueva moneda, el dólar verde, que estaría diseñada para crear incentivos financieros para actividades amigables con el medio ambiente y, en el proceso, atender a problemas de larga data de desigualdad de riqueza y pobreza. Este artículo intenta explicar la naturaleza del dinero y cómo se contempla y utiliza actualmente, para abogar por una reutilización de nuestro sistema financiero para apoyar una agenda ecológica. Tal propuesta contrasta con otras en que no necesitará nuevos recursos, ya sean financieros o tecnológicos, para ser implementada.
"Juntas nos quitamos el miedo". Estudiantes feministas contra la violencia sexista
Authors: Mingo Araceli
Published: June 2020

Con el propósito de conocer el trabajo realizado por estudiantes feministas cuyas colectivas hicieron suya la tarea de denunciar la violencia machista ocurrida en diversos espacios de la Universidad Nacional Autónoma de México, solicité la participación de 11 de ellas para esta investigación. El análisis de la información recolectada en las entrevistas que me concedieron, así como en otras fuentes, permiten apreciar, entre otras cosas, la importante labor que han cumplido con el acompañamiento brindado a quienes han sufrido tal tipo de violencia, así como al hacer visible la presencia continuada de ésta dentro de una institución en la que, al igual que sucede en casi todas las universidades, esa conducta se ha normalizado.
El primer año de la universidad. Condiciones de trabajo docente, modalidades de admisión y abandono estudiantil desde la perspectiva de los profesores
Authors: Pierella María-Paula , Peralta Nadia-Soledad , Pozzo María-Isabel
Published: June 2020

El objetivo de este artículo es analizar las perspectivas de profesores de primer año de algunas facultades de la Universidad Nacional de Rosario, Argentina, en relación con las condiciones en que se desarrolla la docencia universitaria. Dentro de estas perspectivas se indagan específicamente las valoraciones sobre el sistema de admisión y los modos en que interpretan el abandono en los primeros años. En el marco de una investigación que contempla una fase cualitativa y una cuantitativa aquí se presentan los resultados obtenidos en la segunda de estas fases. La técnica de recolección de datos implementada fue un cuestionario a docentes de primer año de la universidad mencionada. Se realizó un análisis de correspondencias múltiples, así como análisis bivariados. Los resultados generales indican que la mayoría de los docentes están de acuerdo con el ingreso directo, con instancias de ambientación y acompañamiento, y otorgan centralidad a las problemáticas propias de los ingresantes como causas principales del abandono en primer año. El estudio apunta a destacar la importancia de reconocer al primer año como un ciclo con características específicas.
La Educación Flexible: estrategia para la configuración de universidades virtuales en Colombia
Authors: Benitez-Saza Claudia-Rocío , Santamaría-Rodríguez Juan-Esteban , Sotomayor-Tacuri Scarlet
Published: June 2020

El artículo revisa y reflexiona sobre la incursión e implementación de la educación flexible (EF) en la educación superior en Colombia como estrategia de formación de profesionales para la virtualización. Es decir, se identifican las fuerzas que han permitido generar una estrategia de poder/saber, y que hoy permite ir constituyendo un profesional flexible para la virtualización del trabajo, a través de una pesquisa de corte arqueológica-genealógica, en donde el uso de la arqueología permitirá ir al pasado, exactamente hasta dónde la EF hace su emergencia como estrategia de formación para la virtualización de los profesionales. Escudriñar la emergencia, remite exclusivamente a cuándo el discurso de “flexibilización” hace su aparición para la constitución de universidades virtuales en Colombia.
Revisión sistémica de la literatura sobre el fenómeno del techo de cristal en las universidades españolas
Authors: Gallego-Morón Nazareth , Matus-López Mauricio A. , Gálvez-Muñoz Lina
Published: June 2020

En el presente trabajo se realiza una revisión sistemática de la literatura sobre el fenómeno del techo de cristal en las universidades españolas. Esta tuvo un horizonte temporal de diez años e incluyó los estudios publicados en las principales bases de datos de revistas indexadas y de organismos oficiales. Se detectan tres características de los estudios: 1) escasez de investigaciones empíricas, 2) estudios de casos aislados y 3) falta de consenso sobre las causas del fenómeno. Se concluye la necesidad de realizar estudios empíricos a nivel nacional centrados en el análisis de las barreras organizacionales.
Reseña del libro de Frida Díaz-Barriga, Dispositivos pedagógicos basados en la narrativa
Authors: Barrón-Tirado Concepción
Published: June 2020

El libro constituye una aportación relevante al campo de la educación al imaginar y experienciar estrategias de investigación, formación y acción pedagógica que nombran, piensan y estudian el mundo de la experiencia educativa de otro modo, a través de dispositivos pedagógicos basados en la narrativa. Asimismo, exploran los sentidos, las comprensiones, las interpretaciones sociales, profesionales, pedagógicas, que producen y ejercitan los aprendices cuando viven esas experiencias y las recrean a través de relatos autobiográficos.
Strategi Kebijakan Pemerintah Venezuela di Tengah Krisis
Authors: Nuryanti Nuryanti , Salsabila Salsabila
Published: June 2020

In the era of president Nicolas Maduro, the Venezuela faced economic crisis. It affects to social and economic decline. The govenment is in the chellenge of public trust and political instablity. The Maduro performance perceived as less effective and repressive that lead to the society questioning about government capacity to solve the problems. Thus, the authors are interested in explaining the efforts of the Venezuelan government in dealing with the crisis. The author uses descriptive qualitative research methods and data collection techniques based on literature study. The data source comes from the literature published by scholars and experts on Venezuelan politics and the Latin American economic crisis. The author notes several actions of the Venezuelan government in dealing with the economic crisis including: (1) economic policies reform; (2) diplomacy of foreign aid to China; (3) food price stabilization: (4) strengthening public health services; and (5) strengthening regional cooperation with organizations in the Latin American region.
Pengaruh Penggunaan Celebrity Endorser Arief Muhammad di Instagram Terhadap Brand Image Erigo Store
Authors: Bulan Setia Indah Setara , Sudrajat Ratih Hasanah
Published: June 2020

In Indonesia there are already many popular local products market their products using social media, which one is in the fashion field, namely local t-shirts. The IDN Times article mentions there are 10 highly recommended local brands namely Erigo, Oomaoo, Sans, Monstore, Thanksinsomnia, Kamengski, Yogs, Sunday Sunday Co., Thinkcookcook, and Dreambirds Artwear. Erigo Store get first ranked with the number of Instagram followers 376.000 in September 2018 so Erigo Store as a local brand already has fans among the people of Indonesia. Seeing this phenomenon, it can be seen that brands have a very important role. To build the Erigo brand into a brand that can be trusted by the public, a strategy is needed to strengthen a brand, which one is through endorsement. To find out the effect of using Celebrity endorser on brand image, this research focus on examining Erigo. Purpose of this study to find the influence of celebrity endorser Arief Muhammad on Instagram Erigo brand image and how much affected partially. Method in this study is quantitative with type descriptive and causal research. Sampling technique using non-probability sampling method of purposive sampling, with respondents 100 people. Data analysis technique is descriptive analysis, classic assumption test, simple linear regression analysis, coefficient determination and hypothesis testing. The results of the t-test found the celebrity endorser had influence on the brand image. This is evidenced by thitung (9,918)> ttable (1,661). Based on result determination coefficient, celebrity endorser Arief Muhammad had an influence of 50.1% on the Erigo brand image.