bluuebunny/crossref_metadata_2025 huggingface dataset:
PENDIDIKAN MULTIKULTURAL DALAM ISLAM “Toleransi Beragama Dalam Kehidupan Masyarakat”
Authors: Siddeh Khoirul Anam , Bakri Maskuri -
Published: May 2023

ABSTRACT Tolerance (tasamuh) is one of the core teachings of Islam which is very urgent to continue to be developed and built in a multicultural society. With tolerance we can appreciate and accept differences with others. So that everything goes according to nature, peacefully, without any coercion and threats from other parties.History records that Muslims have a very high tolerance, starting from the period of the Prophet, the period of the Companions, and subsequent generations. In Indonesia, Muslims have very good tolerance for followers of other religions, so they can live side by side in peace. But on the other hand, recently there have been various conflicts that have led to violence between religious communities. Seeing this phenomenon, it is necessary for the cooperation of all parties to initiate, seek, and realize tolerance in the daily life of this nation's multicultural society. So that the ideals of the formation of a civil society, namely a society that is inclusive, tolerant, humanist, and egalitarian, is actually achieved and is a reality. Keywords: Cooperation-Respect-Tolerance  ABSTRAK Toleransi (tasamuh) ini didefinisikan sebagai satu dari berbagai ajaran utama dalam ajaran dari agama Islam yang begitu penting yang wajib untuk dibangun dan juga dikembangkan secara terus-menerus dalam kehidupan masyarakat yang multikultural. Dengan toleransi ini, semua orang dapat menerima dan juga menghargai berbagai perbedaan dengan yang lainnya, oleh sebab itu semua hal akan berlangsung dengan damai, alami dan tidak terdapat ancaman dan juga paksanaa dari pihak manapun.Dalam catatan historisnya, bahwa umat Islam memiliki toleransi yang kuat dan tinggi semenjak era Rasulullah, para sahabat, dan berbagai generasi setelahnya. Umat islam yang ada di Negara Indonesia ini memiliki sikap dan tindakan toleransi yang kuat dan juga baik dengan pemeluk dari agama yang lainnya, dengan demikian dapat hidup rukun dan juga berdampingan dengan baik. Akan tetapi, dalam suatu fenomena tertentu, akhir-akhir ini timbul beberapa konflik yang tidak kunjung selesai yang berkaitan dengan kekerasan yang memperlibatkan antar umat agama tertentu. Dengan berbagai fenomena yang ada ini, dengan demikian mendesak dibutuhkan kerjasama yang memperlibatkan seluruh pihak guna mewujudkan, menggagas dan juga mengupayakan toleransi dalam kehidupan masyarakat yang multikultural ini. Demikian, impian untuk terciptanya masyarakat yang madani ini dapat terwujud, yakni suatu masyarakat yang bersikap egaliter, humanis, toleran dan juga inklusif ini dapat terwujud Kata Kunci : Kerjasama-Menghargai-Toleransi
Determinan terhadap Niat Membayar Wakaf Uang
Authors: Mudrikah Siti
Published: May 2023

Abstract

Cash Waqf is one of the familiar points that are predicted to be able to provide an alternative to poverty and welfare problems for Indonesia by seeing its great potential. This study aims to determine the reasons why someone intends to pay cash waqf among members of IPNU-IPPNU Centtral Java, who in fact are adolescents and educated, meaning that here the respondent are not people who have not received education. This study uses quantitative methods with purposive sampling. The Questionare was filled in by 100 respondents but only 99 respondents are valid who are members of IPNU-IPPNU in Central Java, the data analysis method uses Structural Equation Modelling (SEM) PLS then the data is processed using the Smart PLS application. The results showed that the subjective norm and Emotional Experience variabels had a positive effect on the intention to pay cash waqf. Meanwhile, Attitude, Perceptions of Behavior Control, and Peer Influences have no effect on the intention to pay cash waqf for IPNU-IPPNU members in Central Java.

Keywords: Cash Waqf, TPB Theory, Emotional Experience, Peer Influences.

 

Abstrak

Wakaf uang menjadi salah satu point primadona yang digadang mampu memberikan alternatif permasalahan kemiskinan dan kesejahteraan bagi Indonesia dengan melihat potensi yang besar. Penelitian ini bertujuan untuk mengetahui alasan seseorang berniat untuk membayar wakaf uang di kalangan anggota IPNU/IPPNU Jawa Tengah yang notabenya mereka adalah usia remaja (usia 19-24 tahun) dan terpelajar artinya disini respondennya bukan orang yang tidak mengenyam pendidikan. Penelitian ini menggunakan metode kuantitatif dengan purposive sampling. Kuesioner di isi oleh 100 orang responden namun yang valid hanya 99 responden yang tergabung dalam anggota IPNU/IPPNU di Jawa Tengah, metode analisis data menggunakan Structural Equation Modelling (SEM) PLS kemudian data diolah menggunakan aplikasi Smart PLS. Hasil penelitian menunjukkan untuk variabel norma subjektif dan Emotional Experience berpengaruh positif terhadap niat membayar wakaf uang. Sedangkan Sikap, Persepsi Kontrol Perilaku, dan Peer Influences tidak berpengaruh terhadap niat membayar wakaf uang bagi anggota IPNU/IPPNU di Jawa Tengah.

Kata Kunci: wakaf uang, Teori TPB, Emotional Experience, Peer Influences.
analisis optimalisasi analisis optimalisasi pengelolaan dana desa untuk kesejahteraan masyarakat di kecamatan aek bilah kabupaten tapanuli selatan
Authors: Rtg Mirnawanti
Published: May 2023

ThisKtypeLofLresearchKis quantitativeKresearch.LThis study uses a quantitativeKapproach in theKformLof financialLratio dataKbasedLon timeLseries.LTheLdata usedKisKannual data.KTheLdataKanalysisLtechniqueKusedMbyLthe researcherLis regressionKanalysis.IThe population inKthis studyKwas the entireKcommunityKof SouthKTapanuliKRegency.LWhile theMsampleKof this researchKis 15 villagesKfrom Aek BilahKDistrict, SouthKTapanuli Regency. TheKsampling techniqueKIof this research isLsaturated sampling.KData collection techniquesLin this studyKused interviewKand documentationKtechniques.  The resultsLof the study showKthat partiallyKthere isKa significantKpositive influenceKbetween Government Implementation,JdevelopmentKImplementation,KCommunityKDevelopment,Community Empowerment onLCommunityKWelfare.KIn contrast toLthe mitigationLthat hasLa negative effect on theKwelfareLof the community,Kit meansKthat there isKno significantKeffectKof the mitigation Kon the welfare of theKcommunity. SimultaneouslyK(together)KGovernment Implementation,KDevelopmentKImplementation,LCommunity Development, Community Empowerment, Management have an effect on Community Welfare in Aek Bilah District, South TapanuliKRegency in 2019-2021Kseen from theLlarge F count of 1421,371 > FLtable 2.45 then H 0    rejectedKand Halaccepted. Soiit can be concluded that simultaneously Government Implementation,KLDevelopment Implementation, Community Development, Community Empowerment, Management have an effect on Community Welfare.L;’;;’

KLO LPOLPP;LKO

Keywords :LOptimization,JVillageLFund,ICommunityJWelfare. KL
Religious Behavior among Female University Students with Full Face Veil in East Kalimantan
Authors: Hidayati Diajeng Laily
Published: May 2023

One form of the expressions of islamic piety among female university is the use of full face veil (known as cadar) in public sphere. Among educated young Muslim women in Indonesia, particularly in university settings in East Kalimantan, the use of cadar as an expression of piety managed to gain substantial ground since 2016. The majority of people often identify the full face veil with the fundamental Islamic movement. Full-face veil users among educated young Muslims, mostly in those resided in urban settings, reject the stigma and labels of hardliners that often attached to them. Believing that such practice as covering face constitute their very understanding of Islamic tenets, this particular group of young educated Muslim women are struggling to challenge the narrative of covering face among Muslim women as indication of backwardness, radicalism and extremism. This paper, therefore, aims at discussing religious behavior among female students who use full face veil in several universities in East Kalimantan. A combination of in-depth interviews and survey technique are utilized to collect data while thematic analysis technique is applied to analyze collected data. Findings reveal that, ideologically speakings, female Muslim university students split into two factions; one that believes wearing cadar as a highly commendable action and one that believes the act to be merely a good deed. They also feel much safer once they started wearing cadar. Most of informants agree that wearing full face veil has made their private lives much safer in comparison to before they wear full face veil.

Keyword: cadar, full face veil, religious behavior, female university student, East Kalimantan
Living Qur’an Dan Hadis Di Tk Syarif Ar-Rasyid Islamic School Medan (Studi Tentang Internalisasi Akhlak)
Authors: Sitorus Masganti , Sumanti Solihah Titin , Gusman Media
Published: May 2023

This study aims to analyze the readiness of children in efforts to internalize morals through the Living Qur'an and Hadith, efforts to internalize morals by teachers through the living Qur'an and Hadith, parental participation in efforts to internalize morals through living. This research was conducted at TK Syarif Ar-Rasyid Islamic School Medan. The research method used is qualitative using a phenomenological approach. Data collection techniques used interviews, observations, and documentation studies. Data analysis uses data reduction, data display, and drawing conclusions. The results showed that Syarif Ar-Rasyid Islamic School Medan Kindergarten students were prepared to accept the process of moral internalization through living Qur'an and Hadith activities. This is evident from the physical and psychological readiness possessed by students. (2) Efforts to internalize morals are carried out in two forms, namely integrated with learning, and outside learning. There are four steps of moral internalization, namely moral determination, practice, habituation, and natural appearance. The media used are posters, MP3 Murotal short suras. The evaluation of moral internalization uses the technique of observing children's developmental achievements. (3) Parental participation is carried out through controlling children's development, supporting and facilitating children's activities, semester meeting activities, getting used to the same attitude at home, participating in parenting recitations.

 

Keywords: Internalization of Akhlak, Living Qur'an and Hadith, Early Childhood
Efectos del entrenamiento de la fuerza en nadadores jóvenes de distancia corta. Una revisión sistemática (2017-2022)
Authors: Zazo Sanchéz-Mateos Ricardo , Castaño Moreno Sebastian
Published: May 2023

Antecedentes: El entrenamiento de fuerza se ha convertido en los últimos años en un imprescindible en las planificaciones tanto de nadadores amateurs como profesionales. El entrenamiento de fuerza en pruebas cortas genera una mejora del rendimiento, ya que la mayor capacidad de fuerza dota a los nadadores de una capacidad de recorrer la distancia de la prueba en menos tiempo. Sin embargo, no existe la evidencia de la utilización del entrenamiento concurrente, por lo que surge la necesidad de estudiar los beneficios de este tipo de entrenamiento en nadadores.

Objetivos: Analizar la literatura científica sobre estudios realizados que incluyan entrenamiento de fuerza y entrenamiento concurrente en nadadores de distancias cortas.

Método: Se analizaron 5 artículos publicados en revistas científicas, buscados en PubMed, Scopus, Sport Discuss y Web of Science, bajo la búsqueda de “Swimming” AND “Strength training” OR Dry-land strength* OR Concurrent training* AND “Sprint” AND “Teenagers”. Estos pasaron el filtro de selección, eliminando duplicados, estudios que no versaran sobre la materia y aquellos anteriores a 2017. Se incluyeron estudios en los que los participantes fueran nadadores jóvenes y se analizase la influencia de la fuerza en pruebas de natación de distancias cortas.

Resultados: El entrenamiento de fuerza, y en concreto el entrenamiento concurrente, consigue mejoras en el rendimiento de los nadadores de distancias cortas, mejorando el inicio de la prueba, la frecuencia de carrera y la fuerza en el tren superior

Conclusiones: El entrenamiento de fuerza concurrente consigue mejoras en el rendimiento para nadadores de distancias cortas.
La introducción al rendimiento deportivo en la sociedad del siglo XXI
Authors: Mendoza Castejón Daniel
Published: May 2023

Desde todos los estamentos se reconoce la realidad de que la sociedad ha cambiado (Alemán-Ramos & García-García, 2018) y que se ha producido una modificación en los valores colectivos e individuales, percepciones de la estructura social, de los roles o de los objetivos vitales de cada persona, ya sean balanceados hacia lo positivo o lo negativo, a saber. Una sociedad mutable y voluble (Bauman, 2001, 2003), sujeta a cambios radicales como en derechos, autoafirmación, identidades o simplemente, cambios tan veloces como en la ciencia y tecnología que, en ocasiones, no nos permiten asimilar la transición, pero ante los que hay que adaptarse...
Natación infantil, la estrategia, la reflexión, el objetivo, la evolución
Authors: De Paula Borges Luciane
Published: May 2023

Esta obra trata de la formación del profesor de natación infantil, que en la actualidad es un tema poco tratado, según la autora. En esta publicación la autora propone un abordaje teoría que aborda las cuestiones relacionadas con el proceso de enseñanza aprendizaje de la natación infantil, en el cual está envuelto los padres, educadores e los alumnos.

Este abordaje la autora la hace a través de la creación y sugerencias de dinámicas de permanentes interacciones de todos los involucrados con el medio acuático, donde la autora apunta soluciones seguras, competentes y consecuentes....
Diferencias entre la mejor marca en piscina de 25 vs 50 metros en la prueba de 200 estilos individual en relación al sexo
Authors: Hermosilla Perona Francisco , Beltrán Díaz Emilio , Juárez Santos-García Daniel
Published: May 2023

Antecedentes: La natación de competición se realiza en piscina corta (25 m) y larga (50 m). Los nadadores normalmente realizan mejores tiempos en piscina corta debido a la mayor cantidad de virajes, por lo que existe un factor de corrección para transformar las marcas realizadas en piscina a corta a marcas equivalentes en piscina larga. Sin embargo, las diferencias entre piscina corta y largas según el sexo en las pruebas de estilos todavía no se conoce.
Objetivo: El principal objetivo de este estudio es analizar las diferencias entre la mejor marca en una prueba de 200 estilos en piscina corta y piscina larga en función del sexo.
Método: Para ello, se seleccionaron los mejores tiempos realizados en piscina corta y larga en la prueba de 200 estilos de 100 nadadores nacionales españoles de primer nivel en dos temporadas.
Resultados: Se llevó a cabo un análisis de los datos mediante una prueba T de student para muestras independientes. Los resultados muestran que en ambos sexos la mejor marca corresponde a la realizada en piscina corta (p<0,001). A su vez, los nadadores masculinos muestran mayores diferencias frente a las mujeres en la prueba de 200 estilos individual entre piscina corta y piscina larga (p<0,05).
Conclusiones: De acuerdo con estos resultados, se sugiere la utilización de un factor de corrección diferente para poder transformar los tiempos entre piscina corta y larga en función del sexo para la prueba de 200 estilos individual.
Palabras clave: natación, rendimiento, piscina corta, piscina larga.
Reduced Southern Ocean Warming Enhances Global Skill and Signal-to-Noise in an Eddy-Resolving Decadal Prediction System
Authors: Yeager Stephen G. , Chang Ping , Danabasoglu Gokhan , Rosenbloom Nan , Zhang Qiuying , Castruccio Frederic S. , Gopal Abishek , Rencurrel Michael Cameron , Simpson Isla R.
Published: May 2023

The impact of increased model horizontal resolution on climate prediction performance is examined by comparing results from low-resolution (LR) and high-resolution (HR) decadal prediction simulations conducted with the Community Earth System Model (CESM). There is general improvement in global skill and signal-to-noise characteristics, with particularly noteworthy improvements in the eastern tropical Pacific, when resolution is increased from order 1° in all components to order 0.1°/0.25° in the ocean/atmosphere. A key advance in the ocean eddy-resolving HR system is the reduction of unrealistic warming in the Southern Ocean (SO) which we hypothesize has global ramifications through its impacts on tropical Pacific multidecadal variability. The results suggest that accurate representation of SO processes is critical for improving decadal climate predictions globally and for addressing longstanding issues with coupled climate model simulations of recent Earth system change.
First-line Nivolumab Plus Ipilimumab for Unresectable MPM in China: a Cost-effectiveness Analysis
Authors: Yang Liu , Song Xiaobing , Zeng Wanxian , Zheng Zhiwei , Lin Wenqiang
Published: May 2023

What is known and objective: The regimen of nivolumab plus ipilimumab(NI) has been recommended by the National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology-Malignant Pleural Mesothelioma (Version 1.2022) and Chinese Guidelines for the Clinical Diagnosis and Treatment of Malignant Pleural Mesothelioma (2021 edition) as the first-line treatment for Malignant Pleural Mesothelioma (MPM). But whether immunotherapy has a financial advantage over conventional chemotherapy (pemetrexed plus cisplatin/carboplatin, C) is uncertain.
Methods: Based on survival and safety data from the CheckMate 743 clinical trial (NCT02899299), a partitioned survival model was constructed using TreeAge Pro2022 software. The model cycle was set to 1 month and the study period was 10 years. The output indicators included total cost, quality-adjusted life year (QALY) and incremental cost-effectiveness ratio (ICER). One-way and probabilistic sensitivity analyses were used to assess the robustness of the results, considering only direct medical costs.
Results and discussion: The ICER for group NI vs. Group C was $375,656/QALY in all randomized patients, $327,943/QALY in patients with epithelioid histology, and $115,495/QALY in patients with non-epithelioid histology. The ICERs of all three different populations all exceeded the willingness-to-pay threshold (three times the per capita gross domestic product of China in 2021). The results of univariate sensitivity analysis showed that the price of pemetrexed and nivolumab had great influence on the analysis results. The results of the probabilistic sensitivity analysis show that the probability of the NI scheme being more economical in all three different populations was 0.
What is new and conclusion: From the perspective of Chinese payers, in patients with unresectable MPM, NI has no economic advantage over C.
Accelerated biological aging, cardiovascular risks, and cardiometabolic multimorbidity: a cohort study
Authors: Jiang Meijie , Tian Sifan , Lin Xihong , Belsky Daniel , Guo Xinbiao , Huang Tao , Baccarelli Andrea , Gao Xu
Published: May 2023

Background
Cardiometabolic multimorbidity (CMM) is the coexistence of two or three cardiometabolic diseases (CMDs), including diabetes, ischemic heart disease (IHD), and stroke, which are recognized as cardiometabolic physiology changes with aging. However, whether accelerated biological aging is associated with the trajectories of CMM development remains poorly understood.
Objectives
To evaluate the association between accelerated biological aging and the trajectories of CMM.
Methods
Baseline accelerated biological aging status of 341,159 adults from UK Biobank was assessed by the Klemera-Doubal method biological age (KDM-BA), PhenoAge, and frailty status. A multi-state model was employed to evaluate their associations with CMM trajectories and corresponding prediction capacities.
Results
During a median follow-up of 8.84 years, 26,319 participants developed at least one CMD, 2,502 of which subsequently developed CMM. Robust associations were observed between three aging measures and the risk from the first CMD (FCMD) to CMM. Adjusted HRs from FCMD to CMM of PhenoAge acceleration and KDM-BA acceleration were 1.15 (95% CI: 1.12–1.19) and 1.14 (95% CI: 1.08–1.21), respectively, and the HRs of frail individuals were 1.33 (95% CI: 1.15–1.53) compared to the non-frail. Classifying the FCMD into three individual cardiovascular diseases, we observed three aging measures separately indicated risk projections to CMM from each disease. People with accelerated aging were with 10 ~ 30% higher probability of death from FCMD or CMM than from baseline. PhenoAge acceleration could predict the CMM risk the best individually (Harrell C-statistics = 0.6254). Two cardiovascular risk scores, Framingham risk score and SCORE2, yielded similar prediction power, but with much reduced risk estimates compared to aging measures.
Conclusions
Accelerated biological aging provide a reservoir for a better prediction of cardiometabolic aging to optimize the subclinical prevention of CMM, and could be targeted for may provide a novel target for early intervention.
Effects of pain neuroscience training combined with neuromuscular exercises on pain, functional disability and psychological factors related to chronic low back pain: A study protocol for a single-blind randomized controlled trial
Authors: Alvani Ehsan , Sheikhi Bahram , Letafatkar Amir , Rossettini Giacomo
Published: May 2023

Background: Chronic low back pain (CLBP) is considered one of the most common health conditions, significantly increasing the disease burden worldwide. Several interventions have been used to relieve CLBP. Pain Neuroscience Education (PNE) approach is used to help patients better understand their pain from a biological and physiological perspectives. Specialists also provide it to reduce pain and disability in chronic pain patients. Also, neuromuscular exercises (NMS) are targeted exercises to control impairments presented in CLBP. In this study, PNE combined with NMS is being investigated.
Objective: This Randomized Control Trial (RCT) aims to investigate whether a program of NMS combined with PNE on pain, functional disability and psychological factors related to CLBP is effective.
Methods/ Design: In this single-blind RCT, 42 patients (men and women, aged 30 to 60) diagnosed with CLBP will be randomly assigned to one of the following groups: (1) PNE plus NMS (21 people) and (2) the NMS (21 people). Outcome assessors will be blinded toward group allocation. The primary outcome will be pain intensity. The secondary outcomes will be disability, fear-avoidance beliefs during work and physical activity, self-efficacy, fear of movement, and kinesiophobia. A blinded assessor will assess all outcomes pre- and post-test. The primary and secondary outcomes will be assessed at baseline and post-intervention (8 weeks) and also at 6 months.
Discussion: Pain neuroscience education has been recognized as an effective approach to chronic low back pain management. PNE appears to be effective when combined with NME to reduce pain, improve the patient's knowledge of pain, reduce disability and reduce psychosocial factors, increase movement and minimize the use of health care. Therefore, PNE combined with NME is an effective intervention for patients with chronic low back pain.
Study registration: The registration reference is IRCT20190427043384N2. Registered on 17 March 2023.
Protocol of a multicenter, single-blind, randomized, parallel controlled trial evaluating the effect of microbiological rapid on-site evaluation (M-ROSE) guiding anti-infection treatment in patients with severe hospital-acquired pneumonia
Authors: Wang Xiuli , Wang Kaifei , Xie Fei , Han Zhihai , Liu Yuhong , Pan Lei , Zhu Guangfa , Cao Zhixin , Yan Peng , Xiao Li , Duan Zhimei , Hu Ye , Xiao Kun , Chen Xuxin , Fu Han , Shi Yinghan , Song Yuwei , Han Xiaobo , Xie Wuxiang , Xie Lixin
Published: May 2023

Introduction: The mortality rate of hospitalized patients with severe hospital-acquired pneumonia (SHAP) remains high. Empirical broad-spectrum antibiotic coverage and the misuse of high-grade antibiotics could lead to the emergence of multi-drug and even pandrug-resistant bacteria. In addition to metagenomic next-generation sequencing (mNGS), microbiological rapid on-site evaluation(M-ROSE) might be a useful technique to identify the pathogens in the early stage, however the effect of M-ROSE guiding anti-infection treatment on prognostic outcomes of SHAP patients is still unclear.
Methods/design: This is a multicenter, single-blind, prospective, randomized controlled trial to evaluate the effect of M-ROSE guiding anti-infection treatment in SHAP patients, which will provide new strategies for the prevention and control of clinical multi-drug resistance bacteria. A total of 166 patients with SHAP, aged 18 years and over, will be recruited from seven centers in Beijing and randomly assigned to the intervention group (M-ROSE combined with mNGS) or the control group (mNGS only) in a 1:1 ratio using the central randomization system. Patients in the intervention group will accept M-ROSE and mNGS analysis, and the control group will accept mNGS analysis. Individualized anti-infective treatment and routine treatment will be selected according to the analysis results. The primary outcome is the 28-day mortality. The safety of the intervention measures will be evaluated during the entire trial period. This trial will be the first randomized controlled trial to evaluate the effect of M-ROSE guiding treatment on mortality in patients with SHAP, and may change the prevalence of multi-drug resistant bacteria.
Ethics and dissemination: This trial adheres to the Declaration of Helsinki and guidelines of Good Clinical Practice. Signed informed consent will be obtained from all participants. The trial has been approved by the Chinese PLA General Hospital (Approval Number: 20220322001).
Trail registration number: ClinicalTrials.gov, NCT05300776. Registered on 25 March 2022.
Clinical and Pathological Features in Women with Vulvar Squamous Intraepithelial Neoplasia: A Single Center Experience from China
Authors: Xiao jingjing , chen ziren , Xiao Yinping , sui long , wang chao , cong qing
Published: May 2023

Objective: This study aimed to investigate the optimal depth of vulvar intraepithelial neoplasia (VIN) and involved skin appendages to provide evidence for treatment.
Methods: The study retrospectively enrolled and analyzed the clinical characteristics of all VINs in the obstetrics and gynecology department of a university hospital from January 1, 2019, to December 30, 2021. The study further explored the thickness of epithelium and skin appendages of 285 women with low-grade VIN (VIN 1) and 285 women with high-grade VIN (VIN 2/3).
Results: The study included 1,474 VINs: 1,139 (80%) VIN 1 and 335 (20%) VIN 2/3 cases. The VIN 1 and VIN 2/3 groups showed a significant difference in HPV infection (P<0.01) but not in cytology (P=0.499). The majority (89.90%, 1,325) of the cases occurred in one area of the vulva, whereas 10.11% had multifocal areas. VIN commonly occurred on the posterior fourchette (76.85%), labia majora (11.61%), and labia minora (9.92%). The VIN 2/3 groupreported a significantly higher positive rate for concurrent Cervical and Vaginal intraepithelial neoplasia (160 of 285) compared with the VIN 1 group (321 of 953) (P=0.000). The involved epithelial thicknesses in VIN 2/3 and VIN 1 were 0.69±0.44 and 0.49±0.23 mm, respectively, both greater than their noninvolved epithelial thickness (0.31±0.19 and 0.32±0.10 mm, p<0.001 and p<0.001, respectively). In circumstances of appendage involvement, VIN thickness was 1.98±0.64 mm.
Conclusions: VIN thickness was generally ≤1 mm for the superficial lesions in non-hairy areas. Lesions extending onto hairy areas were about 3 mm, destroying involved skin appendages.
Performance, Emission and Combustion Characteristics of Aloevera-diesel Emulsified Fuel in a Di Diesel Engine
Authors: Manikandan Rajendran , Raja Thimmarayan , Raja Kengaiah Vijaya , Suresh Gopi , Vezhavendhan Rajasekharan , Kumaresan Govindasamy , Ganesamoorthy Raju
Published: May 2023

Nowadays mankind are very particular about the usage of the energy in most effective manner by keeping the view of less adulterating the atmosphere, are the key aspects of many scientists all around the world. In this particular study, the aloevera diesel has been chosen as the primary fuel and studies have been conducted in emission pollutant characteristics, by choosing appropriate diesel engine. Further to this, stable emulsions have been produced by using aloevera and the same was mixed with diesel as the ratio of 5% and 10% as compound. Moreover, span 80 and tween 80 are used as the surfactant with HLB balance of 9.95. Similarly, the emulsions are prepared with help of mechanical stirrer for exact duration of 30 minutes. In order to carry out the experimental investigation process, single cylinder diesel engine was used with data acquisition system. The entire analyses are carried with two set of methods such as no load and full load. The performance and combustion characteristics such as heat release, combustion pressure, thermal efficiency and specific fuel consumption of brake were measured. Likewise, emission parameters such as CO, HC, NOx and CO2 are measured by using AVL Di-gas analyzer. It was noticed that, increased peak cylinder pressure and greater heat release rate on account of longer ignition delay period. Additionally, increase in engine performance and corresponding reduction in exhaust emission also have been observed upon using alovera emulsified diesel fuel.
Association between olfactory dysfunction and sleep duration in US adults: A cross-sectional study
Authors: Miao Chunyu , Jiang Hongqun
Published: May 2023

Olfactory is closely associated with many diseases, and sleep is the foundation of good health. While the relationship between sleep and olfactory has been reported in numerous studies, there has been relatively little research on whether sleep duration has an effect on smell, so we aimed to evaluate the relationship between sleep duration and olfactory. This study used cross-sectional data from people over 40 years old who took part in the National Health and Nutrition Examination Survey between 2011 and 2012, collecting details on their severe sleep duration, self-report olfactory changes, and several other essential variables. There were 2844 participants, with 23.7% (675/2844) discovering olfactory alterations. Compared with individuals with less than 6 hours of sleep, the adjusted OR values for sleep duration and olfactory dysfunction in 6 to 8 hours of sleep, and more than 8 hours of sleep were 0.7 (95% CI: 0.56–0.88, p = 0.003), and 0.66 (95% CI: 0.52–0.85, p = 0.001), respectively. The association between sleep duration and olfactory dysfunction is an L-shaped curve (nonlinear, p = 0.023). The OR of developing migraine was 0.89 (95% CI: 0.801–0.996, p = 0.042) in participants with sleep seven hours/day. The link between sleep duration and olfactory dysfunction in US adults is L-shaped, with an inflection point of roughly 7 hours/day.
Levels of handwashing and vaccine uptake in Kenya, Uganda, and Tanzania to prevent and control COVID-19: a systematic review and meta-analysis
Authors: Muchangi Josphat Martin , Mturi James , Mukasa Hajra , Kithuki Kioko , Kosgei Sarah Jebet , Kanyangi Lennah Muhoja , Mararo Rogers , Nankaja Mauren
Published: May 2023

Introduction: Coronavirus Disease 2019 (COVID-19) presents a massive challenge in Africa due to overwhelmed and underresourced health systems, as well as the existing burden of communicable and non- communicable diseases. Self-inoculation may occur when an individual touches their mucous membrane following direct contact between their hands and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-contaminated surfaces. Therefore, handwashing can be used along with COVID-19 vaccines to reduce the spread of SARS-CoV-2 and the burden of COVID-19. We were interested in investigating the levels of handwashing and vaccine uptake to control and prevent COVID-19 in Kenya, Uganda and Tanzania using a systematic review and meta-analysis.
Methods: We searched PubMed, African Index Medicus and African Journals Online for studies published since inception to 31st January 2023. We included all studies that assessed: the levels of COVID-19 vaccine acceptance and hesitance as indicators of vaccine uptake; and studies on the levels of handwashing to prevent and control COVID-19 in Kenya, Uganda and Tanzania. Study findings were synthesized by meta-analysis to get the pooled effect measure. Three studies were synthesized qualitatively due to high level of heterogeneity in effect measure precluding a quantitative meta-analysis.
Results: Our search identified 128 articles of which 17 studies with 18,305 participants and 622 vaccination sites were reviewed with 14 of them being meta-analyzed. This systematic review and meta-analysis reports high levels of COVID-19 vaccine acceptance and handwashing in Kenya, Uganda and Tanzania at 67% (95% CI: 55, 78) and 88% (95% CI: 73, 97), respectively. Vaccine hesitance among the participants was low at 31% (95% CI: 15, 49).
Conclusions: Despite their importance in the control and prevention of COVID-19, some countries do not implement handwashing and vaccination effectively. There is a need for public health strategies to raise awareness about the importance of handwashing and the uptake of the COVID-19 vaccine.
Registration: PROSPERO ID CRD42023394698; registered on 6th January 2023.
A Pressure-Sensitive Bioadhesive for Wet Tissues and Organs
Authors: Nam Kum Seok , Park Geonho , Kim Yeji , Hwang Kiwook , Kim Minyoung , Chong Jooyeun , Jeon Jooik , Yang Congqi , Lu Yung Hsiang , Paniccia Christian , Choi Jeongwon , Kim Dong Geun , Lee Haeseung , Oh Seung Won , Kim Sanha , Rhyu Jee-Wook , Kang Jiheong , Hyun Jung Keun , Karp Jeffrey , Lee Yuhan , Yuk Hyunwoo , Park Seongjun
Published: May 2023

Pressure-sensitive adhesives (PSAs) have been a workhorse in diverse applications from the repair of objects to heavy-duty industrial use due to their unique capability to form near-instant and robust yet repeatable adhesion to a wide range of engineering solids via physical bonding. While these characteristics of PSAs are highly favorable in various biomedical applications, commercial PSAs lack adhesion to wet tissue surfaces. Moreover, existing bioadhesives are mostly limited to single-use applications incapable of repeated adhesion and repositioning due to the irreversible nature of chemical adhesion. In this work, we introduce a pressure-sensitive bioadhesive (PSB) that synergistically combines the advantages of viscoelastic PSAs and bioadhesives. Enabled by a one-pot scalable copolymerization of a poly(glycerol sebacate)-co-poly(ethylene glycol) (PGS-co-PEG) block copolymer, the PSB provides near-instant (~ 1 s), robust, and repeatable (over 1,000 times) adhesion to wet biological tissues (i.e., skin, lung, heart) and engineering (i.e., metals, plastics) substrates without prior surface functionalization. We further demonstrate in vitro and in vivo biocompatibility and biodegradability of the PSB and its potential applications as a surgical sealant and the rapid, robust, and repositionable integration of biomedical devices with wet dynamic organs in rat and porcine models.
Iatrogenic Left Ventricle Outflow Tract Ventricular Tachycardia Following Transcatheter Aortic Valve Replacement: A Case Series
Authors: Qavi Ahmed Hassaan , Naniwadekar Aditi , Shah Neeraj N
Published: May 2023

Background: Focal left ventricular outflow tract ventricular tachycardia (LVOT-VT) has been rarely reported following transcatheter aortic valve replacement (TAVR).
Case Presentation: Our first case is a 70-year-old man with bicuspid aortic valve (Sievers type 0) who was found to have severe aortic valve stenosis and underwent uncomplicated transfemoral TAVR with 26-mm Edwards SAPIEN-3 Ultra valve. Five months later, he presented to emergency room with dizziness and dyspnea. ECG suggested VT of LVOT origin. Cardiac MRI revealed no fibrosis. Patient was treated with amiodarone with suppression of VT. Our second case is of an 80-year-old man who was diagnosed with symptomatic severe aortic stenosis. He also underwent transfemoral TAVR with 26-mm Edwards SAPIEN-3 Ultra valve. He had complete heart block postoperatively, necessitating a pacemaker. Twelve hours later, he suffered sustained VT of one hour duration, morphology suggestive of LVOT on ECG. Coronary angiography showed patent coronary arteries. He was also managed with amiodarone with suppression of VT.
Conclusions: LVOT-VT following TAVR may be secondary to disease process affecting the valve and adjacent area, direct mechanical pressure of valve stent against LVOT, change in LVOT geometry, periaortic scar or yet unknown mechanism from an unrelated substrate. Unexplained sudden cardiac death after TAVR may be attributable to VT; hence it is important to be aware of this rare association.
Hybrid Oxide Coatings Generate Stable Cu Catalysts for CO2 Electroreduction
Authors: Albertini Petru , Newton Mark , Wang Min , Lecina Ona Segura , Green Philippe , Stoian Dragos , Oveisi Emad , Loiudice Anna , Buonsanti Raffaella
Published: May 2023

Hybrid organic/inorganic materials have contributed to solve many challenges in different areas of science.1–5 One of the biggest challenges for a more sustainable society is to have active and stable catalysts which enable the transition from fossil to renewable feedstocks, reduce energy consumption, and minimize the environmental footprint. Herein, we synthesize novel hybrid materials where an amorphous oxide coating with embedded organic ligands surrounds metallic nanocrystals. We demonstrate that the hybrid coating is a powerful mean to create electrocatalysts stable against structural reconstruction during the CO2 electroreduction. These electrocatalysts consists of copper nanocrystals encapsulated in a hybrid organic/inorganic alumina shell. This shell locks a fraction of the copper surface into a reduction resistant Cu2+ state, which inhibits those redox processes responsible for the structural reconstruction of copper. The electrocatalyst activity is preserved, which would not be possible with a conventional dense alumina coating. Varying the shell thickness and the coating morphology yields fundamental insights into the stabilization mechanism and emphasizes the importance of the Lewis acidity of the shell in relation to the retention of catalyst structure. The synthetic tunability of the chemistry developed herein opens new avenues for the design of stable electrocatalysts and beyond.
Sex ratio of offspring is not statistically altered following pre-implantation genetic testing under a specific sex selection policy
Authors: Bakkensen Jennifer Bender , Speedy Sedona , Mumm Margaret , Boots Christina
Published: May 2023

Purpose
To determine whether the use of pre-implantation genetic testing (PGT) under a specific sex selection policy is associated with alterations in offspring sex ratio.
Methods
This was a single-center retrospective cohort study of singleton live births from January 2018-December 2020 achieved via single blastocyst non-PGT or PGT frozen embryo transfer (FET). Per institutional policy, sex may be disclosed following PGT. If both sexes are available and morphologic grade is similar, patients may select the sex of the embryo to be transferred. Demographics and cycle characteristics were compared between non-PGT vs. PGT cycles with Mann-Whitney U or 𝒳2. Poisson regression with robust variance estimates was used to model the risk of female vs. male offspring among non-PGT vs. PGT cycles, reported as risk ratio (RR) and 95% confidence interval (CI).
Results(s):
Among 541 live births, 350 (64.7%) were achieved with PGT and 191 (35.3%) without PGT. In both groups, female sex was more common, representing 59.4% of PGT-offspring and 55.0% of non-PGT offspring. After adjusting for potential confounders, the use of PGT was not significantly associated with an increased likelihood of female offspring (RR 1.04, 95% CI 0.98–1.11, p = 0.22).
Conclusion(s):
Singletons born following FET had a higher rate of female sex than male. Allowing sex selection per institutional policy did not increase this ratio. These results contrast with those of prior publications and should motivate individual centers to monitor their own sex ratios. As utilization of PGT increases, local, regional, and national monitoring will become increasingly important.
Forged Facial Video Detection Framework Based on Multi-region Temporal Relationship Feature
Authors: Fang Xing , Hao Yanni , Luo yin , Cao Jia
Published: May 2023

Face generation and manipulation techniques based on deep learning has enabled the creation of sophisticated forged facial video, which is indistinguishable by human eyes. However, illegal use of deep fake technology will have a serious impact on social stability, personal reputation and even national security. Therefore, detection technology of fake facial video is of great significance to protect national security and maintain social order. Although the existing video-based fake face video detection technology has achieved good detection performance on the public fake face video database, there are still the following problems: (1) the existing technology uses 2D attention mechanism to obtain local region features from face images, and lacks a 3D attention mechanism to obtain local area features from face videos; (2) After obtaining local area features, the existing technology is directly used to classify or only model the inter-regional relationship of images, without modeling the temporal relationship between regions of the video. This paper proposes a fake facial video detection framework based on multi-region temporal relationship features, including designing a three-dimensional attention mechanism to extract local features of multiple regions of the face from the video. In order to model the time series relationship between different facial areas, a time series graph convolution neural network is also introduced to extract the time series relationship features between multiple areas. In order to model the time sequence relationship between different face regions, the convolution neural network of time the sequence diagram is also introduced to extract the characteristics of the time sequence relationship between multiple regions. Through the change characteristics of time sequence relationship between facial regions, the timing inconsistency of face video is detected, so as to determine whether the face has been deeply forged. Through experiments on multiple data sets, the experimental results of the model accuracy test show that the method proposed in the present invention achieves the highest detection accuracy, and the accuracy in the FF++ (LQ) data set is 18.19% higher than the benchmark method. The experimental results of the generalization ability test show that the method proposed in the present invention achieves the highest generalization performance, and the detection accuracy of the Celeb-DF data set is 11.92% higher than that of the benchmark method.
Feasibility of collecting longitudinal patient-reported outcomes in individuals with relapsed or refractory large B-cell lymphoma who received chimeric antigen receptor T-cell (CART) therapy
Authors: Balitsky Amaris , Pond Greg , Davies Gwynivere , Fraser Graeme , Kouroukis Tom , Levine Mark , Meyer Ralph , Foley Ronan
Published: May 2023

Purpose
Chimeric antigen receptor T-cell (CART) therapy has shown clinical efficacy in refractory and relapsed large B-cell lymphomas, but is associated with serious acute and long-term toxicities. To understand the patient perspective, we measured a patient-reported outcome (PRO), specifically, health-related quality of life (HRQoL), at multiple time points over one year.
Methods
This was a prospective feasibility study of a cohort of patients who were eligible for standard of care CART therapy, tisagenlecleucel. Demographic data and disease characteristics were collected. HRQoL was measured using FACT-Lym at baseline, and months 1, 3, 6 and 12. FACT-Lym includes FACT-G (physical, social, emotional and functional well-being domains), plus a lymphoma subscale.
Results
Thirty-four of 35 patients approached, consented to participate. Two of them did not receive their infusion due to progressive disease. Fifty percent were female and median age was 62 (23–77). Twenty-nine patients (91%) completed baseline FACT-Lym and 20 of 21 (95%) eligible patients completed 12-month FACT-Lym. 52% completed all 4 post-baseline FACT-Lym measures. Exploratory analyses for changes in FACT-Lym scores are reported.
Conclusion
It is feasible to measure longitudinal PROs in patients who receive CART therapy. This study will inform future studies in evaluating innovative ways to administer CART therapy.
Studying peacebuilding and nonviolence: the ethos and experience of the International Centre of Nonviolence, South Africa
Authors: Harris Geoffrey , Hemson Crispin , Kaye Sylvia , Plug Simone
Published: May 2023

The International Centre for Nonviolence at Durban University of Technology is a major player in the study of peacebuilding and nonviolence in Africa. ICON’s overall aim is to help African communities achieve sustained peace, which means that its teaching, research and community engagement are transformational in their methods and outcomes, with an immediate impact on the lives of those involved. In practice, this means the use of transformative learning processes in our undergraduate teaching and participatory action research in the research theses which we supervise at master’s and doctoral level. This chapter explains the theory, experience and challenges of transformative learning and participatory action research. It then reflects on the effects which these approaches have had on our students and the contributions which they have made to the building of sustained peace across the continent.
periampullary duodenal neuroendocrine tumor in a patient with neurofibromatosis-1: case report and bibliometric analysis
Authors: Zhang Xiaoyu , Yu Jianfa , Li Yang , Li Ping
Published: May 2023

Background: Patients with Neurofibromatosis type 1 (NF1) have an increased risk of developing neuroendocrine tumors, and the most frequent target organs of periampullary neuroendocrine neoplasms (NENs) in NF1 patients are the duodenum and peri-ampullary region.
Case presentation: A 50-year-old male patient was admitted to our hospital after experiencing progressive skin and scleral yellowing for over six months. An abdominal contrast-enhanced computed tomography (CT) scan showed a tumor in the periampullary region, which measures 1.2×1.4cm in size and showed a progressive enhancement. Magnetic resonance cholangiopancreatography (MRCP) showed the dilation of intra- and extrahepatic bile ducts. The patient was diagnosed with an ampullary tumor with the possibility of malignancy. A Whipple procedure was performed. Microscopically, the duodenum tumor invades the mucosa, sphincter, and muscular layer of the duodenal papilla. Histologic hematoxylin and eosin (HE)stain confirmed the presence of duodenal G1 neuroendocrine tumor (NET). In order to get the whole picture of NENs, a bibliometric analysis was performed, which showed that publications about periampullary NENs increase gradually every year, and most of them focus on the treatment and diagnosis of NENs.
Conclusions: We reported a case of periampullary duodenal NET in a patient with NF1, and carried out a bibliometric analysis on periampullary NENs.