bluuebunny/crossref_metadata_2025 huggingface dataset:
Bicarbonate and Serum Lab Markers as Predictors of Mortality in the Trauma Patient
Authors: Talbott Matthew M. , Waguespack Angela N. , Armstrong Peyton A. , Davis John W. , Paul Krishna K. , Williams Shania M. , Golovko Georgiy , Person Joshua , Jehle Dietrich
Published: July 2024

Introduction: Severe trauma-induced blood loss can lead to metabolic acidosis, shock, and death. Identiﬁcation of abnormalities in the bicarbonate and serum markers may be seen before frank changes in vital signs in the hemorrhaging trauma patient, allowing for earlier lifesaving interventions. In this study the author aimed to evaluate the usefulness of serum bicarbonate and other lab markers as predictors of mortality in trauma patients within 30 days after injury. Methods: This retrospective, propensity-matched cohort study used the TriNetX database, covering approximately 92 million patients from 55 healthcare organizations in the United States, including 3.8 million trauma patients in the last two decades. Trauma patients were included if they had lab measurements available the day of the event. The analysis focused on mortality within 30 days post-trauma in comparison to measured lab markers. Cohorts were formed based on ranges of bicarbonate, lactate, and base excess levels. Results: Before propensity score matching, a total of 1,275,363 trauma patients with same-day bicarbonate, lactate, or base excess labs were identiﬁed. A signiﬁcant difference in mortality was found across various serum bicarbonate lab ranges compared to the standard range of 21–27 milliequivalents per liter (mEq/L), post-propensity score matching. The relative risk of death was 6.806 for bicarbonate ≤5 mEq/L; 8.651 for 6–10; 6.746 for 11–15; 2.822 for 16–20; and 1.015 for bicarbonate ≥28. Serum lactate also displayed signiﬁcant mortality outcomes when compared to a normal level of ≤2 millimoles per liter. Base excess showed similar signiﬁcant correlation at different values compared to a normal base excessof −2 to 2 mEq/L. Conclusion: This study, approximately 100 times larger than prior studies, associated lower bicarbonate levels with increased mortality in the trauma patient. While lactate and base excess offer prognostic value, lower bicarbonate values have a higher relative risk of death. The greater predictive value of bicarbonate and accessibility during resuscitations suggests that it may be the superior prognostic marker in trauma.
OPERATOR-THEORETICAL FORMULATLONS OF BOUNDARY VALUE PROBLEM FOR STURM–LIOUVILLE OPERATOR EQUATlON
Authors: Aslanova Nigar , Aliyeva Azada , Aslanov Khalig
Published: July 2024

Abstract. Our aim in that paper is to set the operator theoretical formulation of boundary value problem for Sturm-Liovuille equation with unbounded operator coefficient and boundary condition involving Herglotz-Nevanlinna function of spectral parameter in boundary condition. We define minimal operator and give description of maximal operator.
ON THE CORRECT STATEMENTS OF BOUNDARY VALUE PROBLEMS FOR PDE'S IN BANACH-SOBOLEV SPACES
Authors: Bilalov Bilal
Published: July 2024

Abstract. In this report we consider the Banach Functional Space    X , defined on measure space   m ;  , where n R   is bounded domain, m is the Lebesgue measure in n R . It is defined the Banach Sobolev Space    m X W , generated by norm of    X . Regarding these spaces the elliptic equation is considered and the concepts of classical, local, weak and strong solutions are given. One method for defining the trace, trace operator and trace space generated by space    1 X W are introduced. These concepts allow us to consider the boundary value problems for differential equations regarding the spaces    m X W . Finally, it is considered the Dirichlet problem for polyharmonic equations in Sobolev spaces, generated by norm of symmetric spaces and the correct solvability of the corresponding problem is proved.
Savoirs, réflexivités et fonctions : l’herméneutique de l’immunité
Authors: Mühlethaler Louis
Published: July 2024

Cet article est un compte-rendu du livre : Johannes Türk, Die Immunität der Literatur, Francfort-sur-le-Main, S. Fischer, 2011, 375 p., EAN 9783100393319.
ORIGINS OF CLOTHING
Authors: Нуриза Аманова
Published: July 2024

This article analyzes that people used to live in difficult natural conditions and systematically continued their lives. Attention is drawn to the need to cover the body with something to protect it from bad weather. Various environmental changes, warm and cold weather of the year led to the appearance and further development of clothing.
Integrative taxonomy reveals unanticipated hidden diversity in the monotypic goosefish genus Lophiomus (Teleostei, Lophiidae), with description of three new species and resurrection of Chirolophius laticeps Ogilby, 1910
Authors: Chen Hsuan-Pu , Lee Mao-Ying , Chen Wei-Jen
Published: July 2024

Thought to be monotypic for decades, the only species in the goosefish genus Lophiomus Gill, Lm. setigerus (Vahl), shows a wide range of morphological variation and is distributed widely in the Indo-West Pacific (IWP). In this study, datasets for two mitochondrial and two nuclear genes sequences obtained from samples of Lophiomus collected in different localities across the IWP were constructed and analyzed to explore the phylogeny and species diversity within the genus. Our integrated approach with multiline evidence unveiled an unanticipated richness of at least six delimited species of Lophiomus. Herein, based on materials already available from museums and new specimens obtained primarily through the Tropical Deep-Sea Benthos program surveying IWP benthic fauna, we formally describe three new species: Lm. immaculioralis sp. nov., Lm. nigriventris sp. nov., and Lm. carusoi sp. nov. Also, we resurrect Lm. laticeps stat. rev. from synonyms of Lm. setigerus. These species can be diagnosed by genetics, body coloration, patterns on the floor of the mouth, peritoneum pigmentation, morphometric measurements, and meristic counts of cranial spines, dorsal-fin spines, and pectoral-fin and pelvic-fin rays from each other and from Lm. setigerus. The species Lm. setigerus, as well as the genus Lophiomus, are re-described accordingly based on the new results. Amended identification keys to the four extant lophiid genera and to species of Lophiomus are also provided.
Integrating Digital Skills Competencies into Professional Diploma in Education Curriculum in Vocational and Technical Education in North-East Nigeria
Authors: Umoru Mohammed Lawal , Ibanga Isaac John , Sunday Philip
Published: July 2024

The main aim of the study was to integrate digital skills competencies into Professional Diploma in Education curriculum in Vocational and Technical Education in North-East Nigeria. The study was guided by three research questions and three hypotheses. The study adopted a survey research design was carried out in northeast Nigeria. The population of the study was 1485 comprising 993 Vocational and Technical Education lecturers from 9 Colleges of Education (COEs) where PDE are undertaken in the northeast, 210 ICT experts from the 9 COEs, and 182 Education Supervisors from the Ministry of Education in the six States of the Northeast. The study adopted Simple random sampling and a sample size of 317 respondents was determined using Krejcie and Morgan (1970) sample size table. A structured questionnaire was utilized to gather data for the study. The questionnaire was validated by three experts and a reliability index of 0.86 was obtained using Cronbach Alpha after a trial test. The data for the study was analyzed using mean and standard deviation to answer the research questions while ANOVA was used to test the hypotheses at 0.05 l3v3l of significance. The study revealed that 26 digital skills competences, 26 general performance objective as well as 26 specific objectives each grouped into 8 clusters were found relevant for inclusion into the vocational and technical Professional Diploma in Education (PDE) curriculum in northeast, Nigeria. It was recommended that The National Commission for Colleges of Education (NCCE), and the National Teachers Institute (NTI) should adopt the identified digital competencies into the PDE curriculum of the Vocational and Technical Education curriculum; and the NCCE and NTI should update the curriculum guidelines and standards to explicitly include digital skills competencies as essential components of the PDE curriculum in vocational and technical education.
Justification of the Entrepreneurial Ability of Individuals with Special Needs on the MSME Scale Based on the CDIO Framework
Authors: Katuruni Innas Rovino , Untar Sri Isti , Istia Maria Nino
Published: July 2024

This study aims to explore the CDIO educational framework within the context of vocational education to prepare graduates with special needs for the workforce. The background underscores the significance of the disability issue in contemporary discourse, emphasizing the need for improved awareness and application of existing regulations. The research methodology employed a descriptive approach with data collected through literature review and expert interviews. Preliminary findings indicate that graduates engaged in the CDIO framework are expected to achieve proficiency levels ranging from 3 to 4, demonstrating potential in adequately preparing them to meet workforce standards. In conclusion, the CDIO framework shows promise as an effective approach to enhancing vocational education preparedness for individuals with special needs, highlighting the importance of inclusive and relevant education in addressing current job market challenges.
The postmodern subject from a psychopolitical perspective: An analysis from logotherapy
Authors: Suarez Luna Julio Cesar
Published: July 2024

From a hermeneutic interpretation, this article analyzed the new psychic pandemic configuring a typology of psychopolitical man, provided by digital swarms and mass psychology, that, from logotherapy, can be perceived as a postmodern collective neurosis. We also analyze a self's hyper-reflection as a social phenomenon of psychopolitics, suffering as repression, and the love of narcissistic consumption. Consolidating a sense of life as a social ethos is the answer to finding compromises and responsibility for the individual mission that every human being has as a member of a community and society.
Study and practical implementation of a CHUA circuit synchronized between Master-Slave
Authors: F. Benkhedir  ,   Laboratory of Coding and Security of Information. University of Sciences and Technology of Oran Mohamed Boudiaf Oran-Algeria., N. Hadj Said  , A. Ali Pacha  , M. Maamri
Published: July 2024

The Chua circuit is a simple classical electronic circuit exhibiting chaotic behaviour and considered as a true paradigm of chaos in the real world. In this paper, we propose an innovative practical implementation of two Chua circuits in master-slave configuration using the OrCAD environment. An original procedure allowing the mutual synchronisation of these two circuits is developed and experimentally validated. The detailed study of the synchronised behaviour reveals interesting cryptographic properties, in particular a high sensitivity to initial conditions. A final demonstrator consisting of the two synchronised circuits is then produced, characterised and exploited to extract relevant information for innovative chaos-based cryptographic applications. This work opens up promising prospects for the practical use of the Chua circuit, a recognised simple chaotic system, in the development of advanced cryptographic approaches exploiting the unique properties of synchronised chaotic systems.
Experimental Modal Analysis for Aerial Centerline Fuel Tanks
Authors: S. Omar  ,   Chair Talent and Tech Creativity Center, University of Tabuk, Saudi Arabia
Published: July 2024

External aerial fuel tanks are attached to the aircraft to extend their range and endurance. This experimental study presents a meticulous investigation into the dynamic characteristics of aerial fuel tanks A and B, employing resonance search tests and frequency sweep tests. The experimental setup, involving cyclic excitation and vibration analysis, aimed to predict and compare the tanks' natural frequencies, mode shapes, and structural damping. The acquired data revealed striking similarities in dynamic behavior, affirming that both tanks exhibit consistent responses to external forces. The structural damping values, mode shapes, and resonant frequencies closely aligned, indicating negligible variations in geometry, material, and production technology. The increase in natural frequencies with mode number reflects enhanced structural stiffness and responsiveness. The comprehensive analysis supports the conclusion that tank B is well-prepared for flight testing, showcasing its stability and reliability in dynamic conditions as tank A passed already the flight test.
Hierarchical Needs Status and Work Opportunities towards Organizational Commitment of Elementary School Teachers
Authors: Arlene B. Lagrimas, ,   Laguna State Polytechnic University, San Pablo City,Philippines
Published: July 2024

The study aimed to determine the current hierarchical needs status and work opportunities relative to the level of organizational commitment of school teachers. The study used descriptive method where questionnaire was the primary data gathering instrument. One hundred sixty (160) teachers from Sariaya West District Division of Quezon, contributed to the study. Frequency, percent count, mean, SD and Pearson r were used in the statistical analysis of data. The study revealed as perceived by the Teacher-respondents on their hierarchical needs status were on a high level. Effect of work opportunities in terms of trainings and development, promotion and salary was observed. Maslow’s stages of motivational theory in terms of survival needs, stability needs, enjoyment needs, and esteem needs were related to the teacher’s organizational commitment. Teachers who feel secure in their survival needs, have stable employment, derive enjoyment from their work, and possess a healthy self-esteem are more likely to exhibit higher levels of commitment to their organization. Recognizing and catering to these needs can thus serve as a powerful tool for educational institutions seeking to foster a dedicated and engaged teaching workforce. It was revealed that work opportunities and how they were committed in the organization show that there is significant relationship work opportunities and that of organizational commitment of teachers. This findings emphasizes the role of perceived career prospects and financial rewards as motivators for teachers, highlighting their influence on organizational commitment. Recognizing and investing in these aspects of work opportunities can thus serve as effective strategies for educational institutions to cultivate a committed and engaged teaching workforce. It appears that age and years in service do not moderate the relationship between hierarchical needs status and organizational commitment of the teachers. Age and years in service are not related to work opportunities and organizational commitment of the teachers. This implies that regardless of tenure and age, the impact of perceived work opportunities and hierarchical needs status on organizational commitment remains consistent. Understanding these dynamics can inform organizational strategies aimed at enhancing teacher commitment by emphasizing the importance of psychological fulfillment and job satisfaction, meaningful career development opportunities alongside age and tenure-based considerations. With these, educational institutions can foster a more engaged and committed teaching workforce.
A Study on Reorganization of Source Material for 『Records of Gisaeng and Changgi』: Focusing on “Documents Related to Gisaeng” for September to October 1908 and May 1910
Authors: Mizutani Sayaka Mizutani Sayaka ,   Korean Society of Gyobang and Culture
Published: July 2024

This study targeted a total of 58 pages of Gisaeng-related documents, including all Gisaeng -related documents for [Records of Gisaeng and Prostitute] and 3 pages of [Agenda on Gisaeng and Prostitute Regulation Enforcement Instructions] that did not exist in the original copies and were newly discovered during the preliminary research. Then, this study examined each document and reorganized them based on the time sequence of documentation for a precise and detailed clarification on the details and process of changes in the policies that the Resident-General enforced on the Gisaeng, who was a professional performer during the late Korean Empire.
First, [Gisaeng Regulation Law] began the modern Gisaeng system from September 25, 1908. The Resident-General first set to investigate and identify the personal information of the official Gisaengand transfer them to the Metropolitan Police Department.
Second, the Resident-General enacted and confirmed the [Gisaeng Regulation Law] on September 15, 1908. As the internal official, Byungjun Son, approved the law on September 24, 1908, the [Gisaeng Regulation Law] was enforced on September 25, 1908, as the beginning of the modern Gisaeng system.
Third, the Resident-General established a legal and political system for modernized control and management of Gisaengs (including official Gisaeng) who were working under the existing traditional Gisaeng system by enacting the series of Gisaeng-related laws and regulations, including [Gisaeng Regulation Law], [Standard Regulation of Gisaeng Association], [Proclamation on Gisaeng] in September 1908.
Fourth, the Resident-General enacted the [Notice on Gisaeng and Prostitute Regulation Law Enforcement] and its detailed guidelines, [Detailed Notice on Gisaeng and Prostitute Regulation Law Enforcement] in October 1908, as the guidelines to be aware and conducted by the Japanese police officers of each local police station and each police station branch. The Resident-General also arranged and confirmed the formats for reporting operation, closure, address change, etc., of Gisaeng and prostitutes.
Lastly, Gisaengs who were travelling for local tour, overseas tour, or other performances were required by the Resident-general to submit detailed contracts, contract details, and petition with names and addresses of Gisaeng and all performers. These documents were used to establish a modern management and control system for determining the authorization. This Gisaeng management and control system organized by the Resident-General during the late Korean Empire developed more systematically by the beginning of the Japanese colonial rule.
Chemical Contaminants in Nigerian Agricultural Products: The Evaluation, Alleviation and Consequences on Public Health
Authors: Nnachi Alum, Benedict ,   Publication and Extension Department Kampala International University, Uganda
Published: July 2024

This article provides a plethora of knowledge regarding the assessment of chemical contamination of agricultural goods in Nigeria, potential containment strategies, the problem's influence on public health, and supporting regulatory frameworks. This paper examines chemical contaminants and recommends the implementation of suitable measures to avert adverse health effects. It also focuses on the origins and routes of contamination. Therefore, this conversation highlights the need for multisectoral methods to address this intricate issue, with input from CSOs, government policymakers, academic and research institutions, and business stakeholders. We carefully reviewed recently published papers, journals, and other significant databases relevant to the subject to compile this crucial review article. The goal is to provide much-needed knowledge that will help solve the issue of contaminants in Nigerian agricultural products. By enacting strict laws and policies, raising awareness, and promoting sustainable farming practices, Nigeria can effectively combat the threat of chemical risks to food quality. Keywords: Chemical contamination, Agricultural goods, public health, Regulatory frameworks, Mitigation strategies
Factors Associated with the Utilisation of Family Planning Services among Women of Reproductive Age (15-49 Years) Attending Hoima Regional Referral Hospital
Authors: Solomon Okello ,   Faculty of Clinical Medicine and Dentistry Kampala International University Western Campus Uganda
Published: July 2024

Family planning is defined as the ability for individuals and couples to attain their desired number of children and plan the spacing and timing of their births through the use of contraceptive methods. Promoting family is one of the main targets to reach the SDGs, and timely achievement of family planning targets is expected to accelerate achievement across the 5 SDG themes of people, planet, prosperity, peace, and partnership. Despite the enormous benefits of family planning services, the uptake of the service remains low Uganda. This has resulted in high rates of unwanted pregnancies, unplanned deliveries, unsafe abortions, and maternal mortalities in Uganda. Several factors play an important role in the use of contraceptives among women of childbearing age. The identification of these factors is crucial to the planning and implementation of a suitable family planning programme. The study was designed to determine the factors associated with the utilisation of family planning among women of reproductive age (15–49) attending Hoima Regional Referral Hospital, Western Uganda. This was a hospital-based cross-sectional study. Quantitative and qualitative methods of data collection were utilised to collect data from 251 participants. From the results of the study majority, 182(72.5%) had never used family planning services and 68 (27.5%) had ever used family planning services. Therefore, the level of utilizing family planning services was found to be 27.5%. Thus, the level of utilisation of family planning services among women of reproductive age (15–49) attending Hoima Regional Referral Hospital, Western Uganda, was low, which is significantly associated with the education level and perceived skills of health workers. There is a need to promote and effectively implement policies in support of girls’ education to increase FP service utilisation. Keywords: Family Planning, Women, SDGs, Contraceptives, HIV/AIDS
Exploring the Trends and Patterns in Periodicity of Elements: from Mendeleev to Modern Periodic Table
Authors: Alum Benedict Nnachi ,   Department of Research and Publication, Kampala International University, Uganda
Published: July 2024

Dmitri Mendeleev created the periodic table in 1869, and it has undergone significant modifications to become an essential tool in chemical science today. This abstract provides an informative summary of the evolution of periodic trends and patterns, from Mendeleev's work to the latest complexities in the current periodic table. The first step towards comprehending the periodicity of elements was Mendeleev's periodic table, which he offered as a means of classifying elements according to their atomic weights and chemical behaviours. The periodic table underwent additions and modifications during the ensuing decades as atomic theory and experimental methods advanced. Instead of focusing on atomic weights, the current periodic law is concerned with the precise atomic number. Henry Moseley's discovery of the atomic number altered the elemental positions. This modification allowed for a deeper examination of periodic trends between elements by clarifying elemental relationships. Periodic trend analysis takes into account several characteristics, such as atomic radius, ionisation energy, electron affinity, and electronegativity. This is evident from the fact that each group of elements, ranging from noble gases to alkali metals, has distinct tendencies in both physical and chemical properties. We gathered the necessary materials for this review from a variety of reliable sources, including physical chemistry by K. K. Sharma, inorganic chemistry by J. D. Lee, and other published works. In conclusion, Mendeleev's table's evolution to its current state demonstrates that scientists have been addressing the issue for many generations. The periodic table is still a vital tool for classifying and evaluating the wide range of elements and their characteristics, although there are still many uncharted territories in chemistry. Keywords: electronic configuration, group analysis, periodic trend, periodicity, atomic number, and quantum physics.
The structure of arrhythmias in patients after septoplasty
Authors: Kalmykov I. , Efimenkov I. , Kuznetsov N. , Amirkhanyan S. , Gusev K. , Shilin S.
Published: July 2024

In the present study, an attempt was made to study and evaluate the structure of cardiac arrhythmias in men and women using septoplasty under general anesthesia. Among all types of cardiac arrhythmias, premature atrial complexes and premature ventricular complexes extrasystoles (PAC and PVC) were most often found and were detected in all patients. Atrial tachycardias (AT) in men were significantly more likely to occur in the periods before surgery, during and after it, than in women. PACs at night was significantly more common in women. Ventricular arrhythmias (VA) were significantly more common in women than in men. Moreover, PVCsin women were detected significantly more often in all periods of observation. ATs and VAs in men were significantly more common after surgery. VAs in women were significantly more likely to occur before surgery than after it. Thus, the results of the study showed that of the considered cardiac arrhythmias during septoplasty under general anaesthesia much more frequently in men and women at all stages of the survey found PVCs, and the women of their significantly higher than in men. Cardiac arrhythmias (PAC and PVC) predominated mainly in the postoperative period with the exception of PVCs in women, which was higher in the preoperative period. Reducing the number of arrhythmias observed during operation, possibly due to the impact of drugs for general anaesthesia.
Changes in Expression of Chemokines, Cytokines and their Receptors under the Action of Selank and its Fragments
Authors: Kolomin T. , Mikhalskaia P. , Sedelnikova A.
Published: July 2024

Currently, pharmacological preparations based on endogenous regulatory peptides are being actively studied as the most promising class of drugs that are practically devoid of side effects. This class of drugs includes a synthetic analogue of tuftsin - Selank. Selank, on the one hand, has an anxiolytic and nootropic effect, and on the other hand, it has pronounced antiviral properties. During the study of the immunomodulatory effect of Selank, we proved that both the whole peptide and its individual fragments can cause significant changes in the expression of genes of chemokines, cytokines, and their receptors in the mouse spleen 6 and 24 hours after a single injection. We also showed that a change in the mRNA level of most of the considered genes is observed after the introduction of Gly-Pro, previously proposed as a minimal fragment of Selank with antiviral activity - pharmacophore.
Optic Neuritis as Manifestation of Local Viral Encephalitis (Clinical Observation)
Authors: Korsakova E. , Korsakova N.
Published: July 2024

In the practice of an ophthalmologist and neurologist, the identification of relationship between optic neuritis and inflammation of the brain tissue is accompanied by significant diagnostic difficulties. In this regard, the role of interdisciplinary consultations is valuable, as an ophthalmologist knows the methods of ophthalmological diagnostics, which allow for topical diagnosis of the brain damage level, but for a neurologist, these methods are inaccessible. A clinical case of herpetic optoencephalitis (descending optic neuritis against the background of local encephalitis) in a teenager with a favorable outcome after conservative treatment is considered in the given paper. Conclusion: It is important to remember that during the optoencephalitis formation, its ophthalmic manifestations can remain not only the manifestation of this focal neurological pathology for a long time, but also require the timely appointment of appropriate routes of administration, doses and duration of etiotropic drugs use, therefore, the utmost diagnostic alertness regarding viral encephalitis (opticoencephalitis) is important at the slightest suspicion of a descending origin of the identified eye tissues inflammation.
Polymorphism of Genes of Platelets` Integrins and Fibrinogen as a Risk Factor for Homeostatic Disorders in Preeclampsia
Authors: Vlasova T. , Shishkanova T. , Arsenteva E. , Markina A. , Belova L. , Polozova A. , Kotlyarova E.
Published: July 2024

The development of perinatal obstetrics is associated with the need for a detailed study of the pathophysiological mechanisms of preeclampsia (PE). Materials and methods. A prospective cohort study included 173 patients aged 18-45 years with a singleton pregnancy at a gestational age of 22-41 weeks at the Mordovian Republican Central Clinical Hospital. There were 3 groups: group I (n=63) - pregnant women with moderate PE, group II (n=58) - patients with severe PE, group III (control) (n=52) - pregnant women with physiological pregnancy. The assessment of the prevalence of polymorphic variants of genes was by PCR diagnostics. A laboratory study of hemostasis, microcirculation and thromboelastography (TEG) parameters was performed. Results. In patients with severe preeclampsia, there is a high prevalence of homozygous C/C variants (46.5%) of the ITGB3 gene and heterozygous C/T variants (55.5%) of the ITGA2 gene, hetero-(G/A) and homozygous (A/A ) variants of the fibrinogen gene (FGB) - 48.3 and 36.2%, respectively. It is associated with such hemocoagulation disorders as an increase in the prothrombogenic potential of the blood based on a decrease in the number of platelets, prothrombin time and antithrombin III against the background of an increase in fibrinogen and an increase in the strength and volume of the blood clot according to TEG. Conclusions. The severity of thrombophilia is associated with the severity of preeclampsia; pathological alleles of the studied genes are most often recorded in patients with severe PE and severe hemostasis disorders.
Morphofunctional changes in brain and peripheral blood in aged Wistar rats due to AlCl3 exposure
Authors: Sentyabreva A. , Miroshnichenko E. , Tsvetkov I. , Kosyreva A.
Published: July 2024

The purpose of the study: To examine morphofunctional changes of brain and peripheral blood in aged Wistar rats to observe adaptive reactions as a response on AlCl3 exposure. Methods: The work was performed on male Wistar rats, 24 months of age. Animals consumed a solution of AlCl3 100 mg/kg per day for 60 days. Morphological changes of neurons and microglia, mRNA expression levels of pro- and anti-inflammatory cytokines, microglia activation markers, amyloid-related and hypoxia-related proteins, as well as monocyte and lymphocyte subpopulations in peripheral blood, were examined. Results: AlCl3-treated old rats showed the increasing of hyperchromic neurons in 2 out of 3 examined regions of the hippocampus; morphological features of microglia cells’ dystrophy; the upregulation of pro-inflammatory cytokine Il-18 and the downregulation of anti-inflammatory cytokine Il-10, as well as App, Bace1, and Hif-1a; the decreasing of percentage of B-cells, general CD3+ lymphocyte population, including CD4+ T-helpers and CD8+ cytotoxic cells, but the increasing of CD4+/CD8+ ratio in peripheral blood. Conclusion: AlCl3-treated aged rats demonstrated systemic maladaptation to AlCl3 impact. Unlike adult rodents, aged ones have the background of inflammaging, as well as elderly people. The exposure of AlCl3 could potentially be a replacement of integral cellular and molecular processes accompanying age-related diseases, presenting in most elderly people, as an enhancer of inflammaging and hypoxia. These conditions make this model of neurodegeneration a reliable one to explore the initial mechanisms of such detrimental process, as well as prove aged rats more suitable subjects to perform future researches in this field.
Current State of Factors Influencing the Development of Running Speed in the 100m Sprint for Non-Specialized University Students at Tan Trao University
Authors: Quoc Luc Hung
Published: July 2024

This study provides a comprehensive analysis of the current state of factors influencing the development of running speed in the 100m sprint for non-specialized university students at Tan Trao University. The primary objective of this research is to identify and examine the key elements that contribute to the improvement of short-distance running speed among this student population.
Through an extensive review of both domestic and international literature, the study encompasses 20 relevant publications from 2012 to 2024, establishing a robust foundation for understanding the current state of research and best practices in this domain. The findings reveal that the development of running speed is influenced by a multifaceted interplay of biomechanical, physiological, psychological, and training-related factors.
Specifically, the study delves into the significance of proper running technique, muscle strength and power, aerobic and anaerobic fitness, energy system utilization, athlete motivation, goal-setting, and mental preparation. Additionally, the paper highlights the importance of implementing effective training programs that incorporate periodization, volume and intensity management, and evidence-based injury prevention strategies.
The implications of this study are paramount, as it offers valuable insights for coaches, physical education instructors, and sports science professionals working with non-specialized university students. The findings can inform the design and implementation of comprehensive training programs aimed at enhancing the speed capabilities of this population, while also prioritizing injury prevention and overall athletic development.
The Role of Cultural Tourism in the Preservation and Promotion of Traditional Cultural Values among Ethnic Minority Groups in Tuyên Quang
Authors: Van Bui Tuong
Published: July 2024

Cultural tourism has emerged as a vital mechanism for safeguarding and disseminating the traditional values and practices of ethnic minority communities around the world. This study examines the role of cultural tourism in preserving and promoting the unique cultural heritage of ethnic minority groups residing in Tuyên Quang province, Vietnam. Drawing on qualitative fieldwork and in-depth interviews with local stakeholders, the research investigates how tourism-oriented initiatives have been leveraged to bolster the visibility and vitality of distinct cultural identities in the region.
The findings indicate that when carefully designed and implemented, cultural tourism can serve as an effective tool for conserving endangered traditional arts, rituals, and livelihoods among ethnic minority populations. By facilitating deeper engagement with indigenous knowledge systems and cultural expressions, such initiatives have succeeded in counteracting the homogenizing forces of globalization and revitalizing community pride in ancestral traditions. Furthermore, the study highlights how tourism-driven preservation efforts have generated sustainable economic opportunities for minority groups, empowering them to be active stewards of their own cultural heritage.
The research offers critical insights for policymakers, tourism operators, and community organizers seeking to harness the transformative potential of cultural tourism for the benefit of marginalized ethnic minority communities. It underscores the need for holistic, community-based approaches that prioritize the agency and self-determination of these groups in the design and management of cultural tourism programs. Overall, the study contributes to scholarly debates on the dual role of tourism as both a threat and an opportunity for the protection of intangible cultural resources worldwide.
Implementing Extracurricular Activities in English Teaching Enhance to Communication Skills for Students at Tan Trao University
Authors: Dung Nguyen Thi Thuy
Published: July 2024

This study explores the effectiveness of employing communicative activities in teaching English speaking skills to students at Tan Trao University. In the context of globalization, proficiency in English speaking is crucial for students' academic and professional success. Traditional teaching methods often fail to engage students actively, leading to limited improvements in their speaking abilities. This research proposes a shift towards interactive and communicative activities that encourage active participation and real-life communication practice. By incorporating role-plays, group discussions, and interactive tasks into the curriculum, students are provided with a dynamic learning environment that enhances their speaking proficiency. The findings suggest that these communicative activities not only improve students' fluency and confidence in speaking English but also foster a more engaging and enjoyable learning experience. This approach underscores the importance of practical application in language acquisition and offers a model for other educational institutions aiming to enhance their English language programs.
Self-Efficacy, Task Value and Metacognitive Self-Regulation as Predictors of Vietnamese High School English Learners’ Achievement
Authors: Baissane Omar , Zaid Hassan
Published: July 2024

The purpose of this study is to determine the extent to which self-efficacy, task value, and metacognitive self-regulation predict Vietnamese high school students’ English language achievement. In this quantitative study, 403 Vietnamese participants were requested to fill out the Motivated Strategies for Learning Questionnaire to measure self-efficacy, task value and metacognitive self-regulation. The English language achievement was measured by the students’ self-reported final grades. In order to analyse the data, multiple regression analysis was used. The results revealed that self-efficacy, task value and metacognitive self-regulation were positively correlated with English language achievement and they significantly predict English language achievement when they were taken together as a set. Moreover, the results showed that self-efficacy was the only significant predictor of language achievement at an individual level.
Cellular Pathophysiology in Zoonotic Transmission of Orthopoxviruses (OPXVs) from Animal Host to Human
Authors: Kerna Nicholas A. , Flores John V. , Jeremiah Shoyoye Muyiwa , Pruitt Kevin D. , Carsrud N.D. Victor , Ngwu Dabeluchi C. , Holets Hilary M. , Azi Cornelius I. , Anderson II Joseph , McKee Devin , Nwokorie Uzoamaka , Dhumad Rafad
Published: July 2024

Orthopoxviruses (OPXVs), belonging to the Poxviridae family, are large, double-stranded DNA viruses known for their zoonotic potential and impact on human and animal health. This review explores the transmission dynamics of OPXVs from animal hosts to humans and the underlying cellular pathophysiological mechanisms.
Animal hosts such as rodents, primates, and livestock are central in the ecology of OPXVs, with transmission typically occurring through direct contact or exposure to contaminated materials. Clinical manifestations in animals range from skin lesions and fever to respiratory and gastrointestinal symptoms, reflecting the diverse tissue tropism of these viruses. Humans primarily acquire OPXVs through contact with infected animals or their products, highlighting the zoonotic risk posed by these viruses.
At the cellular level, OPXV infections involve complex interactions between viral proteins and host cell receptors, triggering robust immune responses characterized by cytokine release and inflammation. The viruses replicate within the cytoplasm without accessing the host cell nucleus, evading detection by nuclear sensors and exploiting cellular machinery for viral assembly.
A comprehensive grasp of OPXV transmission dynamics and cellular pathophysiology is requisite to devise effective prevention and control strategies. Insights into host immune responses and viral replication mechanisms provide a foundation for antiviral drug development and vaccine strategies. This review synthesizes current knowledge on OPXV ecology, transmission, and cellular interactions, emphasizing their significance in veterinary, medical, and public health contexts.
Some thoughts after a trial run of GitHub’s Copilot Workspace
Authors: Lambert Joshua W. , Azam James Mba , Gupte Pratik , Kucharski Adam
Published: July 2024

GitHub recently previewed ‘Copilot Workspace’, which aims to use generative AI to assist software developers. Rather than just giving in-line suggestions, as GitHub copilot does, workspace allows users to map out and execute entire projects. We got early preview access to the tool, so decided to see how well it performed for our needs in Epiverse-TRACE.
The paradox of process metaphysics
Authors: Timmenga Friso
Published: July 2024

This essay critically discusses the rising interest in process philosophy in recent years. I argue that the appeal of process philosophy lies in its ability to circumnavigate the binary dichotomies pervasive in European philosophy and defend an interpretation of process philosophy in terms of relationality, difference, and change. After outlining the central tenets of process philosophy, Graham Harman’s critique of a relational account of process philosophy is examined, particularly his assertion that this type of philosophy cannot fully explain genuine change. Despite the merits of Harman’s critique, I will show that his object-oriented ontology faces similar limitations. Turning to Graham Priest’s dialethism I suggest that philosophy, instead of striving for a consistent representation of fundamental metaphysics, must embrace paradox to some extent. This leads the philosophical discipline to understand itself as a transformative process.
Exploring Financial Risks in Relation to Performance of MPESA Agents in Rural Areas, Kenya
Authors: Wamukekhe Shedrine Butali
Published: July 2024

The growth of mobile banking services, specifically Mpesa, has transformed financial transactions in Kenya, particularly in marginalized and rural regions. Ever since Safaricom introduced Mpesa in 2007, it has enabled various financial transactions like money transfers, bill payments, savings, and loans, becoming vital to Kenya's financial infrastructure. In rural areas, Mpesa shops are at risk of facing financial challenges which can impact their operations and long-term success. This research investigates how liquidity, credit, and operational risks affect the financial performance of Mpesa outlets in rural Kenya. The mismatch between cash coming in and going out results in liquidity risks, which can cause service interruptions and unhappy customers. Credit risks, resulting from borrowers failing to repay loans on time or defaulting, put pressure on cash flow and the stability of finances. Operational risks like technical failures, fraud, and regulatory non-compliance pose additional threats to the functionality and customer trust of the shops. By thoroughly analyzing pertinent literature and empirical data, this research investigates the way in which these risks interplay and impact the economic sustainability of Mpesa shops. The results are intended to guide improved risk management methods and policy suggestions to strengthen the resilience and sustainability of Mpesa agents, guaranteeing ongoing availability of crucial financial services in rural Kenya.
LANDSLIDE ON RAILROAD TUZLA – ZVORNIK
Authors: Đujić Anđa , Đurić Neđo , Mitrović Petar
Published: July 2024

On the railroad Tuzla – Zvornik, on stacionage km 41+150 – km 41+200, there is a landslide on the left cut, 50 m before the entrance to the tunnel. There have been partial repairs over the years, but without any former detailed researches, so no proper solutions were found. Frequent repairs, like building shallow supporting walls, haven’t given proper results, hence the giant landslide myth was created. The position of the landslide is such that it is inadequate for certain types of research works and, for repair works it is necessary to change the regime of railroad traffic.

By translated geotechnical researches it has been stated, the landslide is forming on clay slates which represent terrain substrate. These are very affected by atmospheric influences. They are very erosive, easily broken and crushed. Simply put, they are unwanted, in an engineer-geological sense. In the roofing area, there are gravel-sand-clay sediments, over which there is topsoil. In natural state conditions they are stable, but when cutting the dip, especially in the presence of atmospheric precipitations, the natural balance is then tipped and the sliding process is activated.
BUILDING UNDERGROUND FACILITIES - GARAGES AND ROAD ON THE MAIN SQUARE IN BIJELJINA
Authors: Đurić Neđo , Bajić Željko
Published: July 2024

Town of Bijeljina, with about 70 000 inhabitants, is located in the northeastern part of Republic of Srpska, Bosnia and Herzegovina. Sudden increase of population in the last 15 years, and the increased number of cars in the city, create traffic, traffic, both in terms of movement of motor vehicles, and their parking. If in fact have in mind that cars are on average older than 15 years, it is obvious that the crowd next to traffic, and the endangered environment of the harmful gases that are free from motor vehicles. Successfully resolve these problems, it is possible the construction of underground garages and road to the central city square.
BLACK SOIL ON HARD LIMESTONE AT THE HABITATS OF NATURALLY-OCCURRING PYRETHRUM
Authors: Cupać Svjetlana
Published: July 2024

Pyrethrum (Tanacetum cinerariaefolium Trev.), a herbaceous perennial plant and member of the Asteraceae family, grows as an endemic species in the coastal region of Eastern Adriatic. It has long been an object of scientific scrutiny and used in practice for its insecticidal components contained in the flower (pyrethrines I and II) which constitute a natural and environmentally safe product more acceptable than similat synthetic products. Wild pyrethrum flourishes on degraded soils and we have attempted to stady more closely its ecological and micro soil requirements. Resultes of morphological, as well as phisical and chemical soil properties study are presented in the paper.
OPTIMAL INTERVALS OF GEOTHERMAL PIPE-LINE OF DISTRICT HEATING SYSTEM OPERATION
Authors: V. Đuričković Veljko
Published: July 2024

Correct design of district heating network requires that each of its segments operates in optimal working interval, meaning that total costs of each segment (investment and operational costs) are minimal. In order to accomplish that, the designer needs to obtain all information regarding main dependences between segment load, its diameter and costs. Also, geothermal district heating system differs from traditional district heating system by source of heating energy, its treatment, transport, distribution and use. This article explains the methodology how to determine the optimal working interval of geothermal network heating system.
LIMITING FACTORS IN IMPLEMENTATION OF THE RE- CULTIVATION PROCESSES OF THE TECHNOGENOUS LAND
Authors: Sufi-Mićić Slavka
Published: July 2024

The principle of the integral approach to environmental protection requires harmonised legal acts (laws) in a number of fields of social action, thus creating clear grounds in relation to jurisdiction, higher sphere of social action and sanctioning of failure in implementation of the prescribed measures. Such grounds are still non-existing in the Federation of BH, and it is probably that the situation will remain unchanged in the upcoming period. This is specifically related to the issues of damaged land in the areas of mining activities, where large areas with technogenous land are accummulated. Re-cultivation of these areas is not only a legal obligation, which ends with preparation of the project documentation, but also a chance for thousands of hectares to be restored in the function and in the development strategies with the most appropriate intended use.