bluuebunny/crossref_metadata_2025 huggingface dataset:
PERLUKAH RESEP DOKTER UNTUK OBAT BAHAN ALAM?
Authors: Aju Tofiana Fadjar
Published: April 2022

Pandemi Covid-19 yang melanda hampir di seluruh dunia di awal tahun 2020, telah banyak mengubah pandangan masyarakat terhadap pemanfaatan bahan alam sebagai pengobatan.Salah satunya adalah pemanfaatan minyak kayu putih yang di klaim dapat mengobati Covid19, padahal minyak kayu putih selama ini diketahui hanya sediaan topikal yang membantumelegakan hidung dan tenggorokan. Pemanfaatan bahan alam baik berasal dari tumbuhan, hewan, mineral dan/atau campurannya tidak dapat serta merta diterima sebagai bahan obat (obat bahan alam) dan berfungsi sebagai pengobatan manakalah bahan alam tersebut belum memiliki evidence base yang memadai, baik dari sisi keamanan dan manfaat. Minyak kayu putih dapat diklaim mengobati Covid-19 setelah hasil uji pra klinik dan uji klinik membuktikan hal tersebut. Dan juga bukan misal karena resep dokter, bahan tersebut menjadi dapat digunakan sebagai pengobatan. Tujuan penulisan ini adalah memberikan alternatif tentang kapan resep dokter untuk obat bahan alam diberikan melalui pendekatan logic frame,disandingkan dengan pemberian resep dokter pada obat modern atau obat kimia.
EFEKTIVITAS KEBIJAKAN PEMBERLAKUAN KARTU VAKSIN SEBAGAI SYARAT BERPERGIAN KE TEMPAT-TEMPAT PUBLIK PADA MASA PANDEMI
Authors: Azza El Darman Atiqa
Published: April 2022

Artikel ini membahas tentang Pemerintah Kota (Pemkot) Padang yang mengeluarkan surat edaran terkait terkait pemberlakuan wajib vaksin di lingkungan hotel, mall dan tempat publik lainnya di Kota Padang. Surat itu bernomor 400.1014/BPBD-Pdg/X/2021 tentang Percepatan Vaksinasi dan Pemberlakuan Aplikasi Peduli Lindungi Pencegahan Pandemi Covid-19. Namun terdapat beberapa masalah yang membuat kebijakan ini kurang efektif untuk dijalankan. Tujuan penelitian ini adalah untuk menjelaskan efektivitas kebijakan dari surat edaran ini dengan menggunakan teori indikator tepat kebijakan, tepat pelaksanaan, tepat target, tepat lingkungan dan tepat proses. Metode penelitian ini yaitu kualitatif deskriptif. Hasil penelitian ini mengungkapkan bahwa kebijakan ini belum efektif dijalankan. Rekomendasi penelitian ini adalah kebijakan ini perlu ditinjau ulang untuk melihat masalah-masalah yang terjadi, perlunya sosialisasi terkait kebijakan agar masyarakat lebih paham, dan perlunya pemerintah mengadakan agenda terbuka untuk masyarakat untuk vaksinasi gratis.
KEBIJAKAN PARIWISATA INDONESIA PADA ERA PANDEMI COVID-19
Authors: Nasution Torang
Published: April 2022

Saat ini ada terjadi pergeseran (shifting) yang mempengaruhi dinamika pariwisata di Indonesia, yaitu terjadinya Pandemi Covid 19 yang berdampak pada perubahan drastis multi-sektoral dan multi-dimensional, dan lahirnya Undang Undang Cipta Kerja atau yang dikenal dengan Omnibus Law. Tantangan pembangunan ke depan semakin menuntut berbagai terobosan yang dapat menjawab permasalahan dan kebutuhan riil dalam rangka mencapai daya saing destinasi yang kompetitif. Dalam konteks regulasi, berbagai kelemahan berupa tumpang-tindih dan miskoordinasi melalui UU Cipta Kerja dan review Undang-undang Kepariwisataan diharapkan dapat menjadi jawaban penyelesaiannya. Namun di sisi lain, aspek pengelolaan melalui kolaborasi lintas sektor yang masih ditemui berbagai kendala perlu pula menjadi perhatian. Di masa lalu, para aktor yang memiliki berbagai kewenangan kurang berjalan sinergis dan kadang justru cenderung mengedepankan ego sektornya. Pembangunan dan pengembangan kepariwisataan Indonesia, baik di tingkat pusat maupun daerah, perlu melakukan kebijakan pembenahan (revamping) dengan merekontektualisasi strategi pengembangan destinasi pariwisata melalui pemanfaatan suatu instrumen pengelolaan dan tatakelola destinasi pariwisata yang berkelanjutan, bertanggungjawab, berkeadilan buat masyarakat setempat. Instrumen pengelolaan dan tata kelola destinasi dimaksud adalah konsep Destination Management Organization (DMO) dan Destination Governance (DG). Platform DMO-DG diharapkan dapat memberikan suatu solusi dalam rangka mencerahkan dan menyalakan kembali pariwisata di daerah (reignite tourism). Berdasarkan pembelajaran pengelolaan destinasi yang baik, maka konsep Destination Management Organization (DMO) & Destination Governance (DG) dapat semakin berperan dalam memperkuat daya saing destinasi pariwisata, khususnya di masa adaptasi baru. Selanjutnya dapat diterapkan pada pengembangan destinasi nasional pada 5 (lima) destinasi prioritas, yaitu kawasan Danau Toba, Mandalika, Borobudur, Labuan Bajo dan Likupang.
PENGEMBANGAN KEMAMPUAN BERPIKIR KRITIS ANAK USIA DINI MELALUI STORYTELLING DI TK AMARTANI BANDAR LAMPUNG
Authors: Anggraini Gian Fitria , Pradini Susanthi , Sasmiati Sasmiati , Haenilah Een Y , Wijayanti Dwi Kurnia
Published: April 2022

Pengabdian ini bertujuan untuk memberikan pelatihan storytelling kepada pendidik anak usia dini dalam rangka mengembangkan kemampuan berpikir kritis anak usia dini melalui kegiatan membacakan cerita (storytelling). Adapun secara khusus tujuan dari pelatihan ini adalah untuk meningkatkan: (1) pemahaman guru tentang pentingnya storytelling sebagai salah satu cara mengembangkan kemampuan berpikir kritis pada pembelajaran anak usia dini; (2) pemahaman tentang strategi pembelajaran melalui kegiatan storytelling sebagai salah satu cara mengembangkan kemampuan berpikir kritis anak usia dini. Metode yang dipilih dalam kegiatan pengabdian ini adalah dengan memberikan pelatihan pendampingan storytelling baik itu melalui penyuluhan (pemberian materi), diskusi, latihan simulasi, serta pemberian tugas (workbook). Pelatihan dilaksanakan dalam beberapa tahap yaitu, tahap awal (sosialisasi), tahap pelaksanaan, dan evaluasi. Sasaran kegiatan adalah guru TK di Gugus Labuhan Ratu, Bandar Lampung yang diselenggarakan di TK Amarta Tani HKTI Bandar Lampung berjumlah sekitar 35 orang. Pengujian keefektifan pelatihan dilakukan melalui uji pre-test dan post-test, yang dianalisis menggunakan uji beda. Berdasarkan hasil analisis terdapat 66% peserta yang mengalami kenaikan skor sebelum dan sesudah pelatihan, dan kenaikan rata-rata sebesar 1.2. Hal ini menunjukkan bahwa terdapat perbedaan serta peningkatan pemahaman peserta dalam melakukan aktifitas storytelling sebagai salah satu bentuk kegiatan yang dapat membantu anak mengembangkan kemampuan berpikir kritis.
PENYULUHAN DAN PELATIHAN DIVERSIFIKASI OLAHAN LABU SIAM DI KELOMPOK PENGRAJIN NURUL HUDA, KOTABARU, BANDAR LAMPUNG
Authors: Herdiana Novita , Suharyono Suharyono , Erna Maria , Yuliandari Puspita , Anungputri Pramita Sari
Published: April 2022

Labu Siam termasuk jenis sayuran yang mudah mengalami proses kebusukkan, oleh karena itu untuk memperpanjang masa simpannya labu siam dapat dibuat dalam bentuk lain salah satunya adalah dodol labu siam. Dodol adalah produk makanan yang dibuat dari tepung beras ketan, santan kelapa dan gula dengan atau tanpa penambahan bahan rnakanan dan bahan tambahan makanan lain yang diizinkan (SNI 01-2986-1992). Dodol termasuk jenis makanan setengah basah yang memiliki sifat plastis, padat dan mempunyai kadarair 10-40 %; aw 0,60-0,90, (Soekarto, 1979). Kelompok Pengajian Nurul Huda Kelurahan Kotabaru Kecamatan Tanjung Karang Timur Bandar Lampung terdiri dari kaum ibu –ibu yang kebanyakan berprofesi sebagai ibu rumah tangga. Secara umum perekonomian Kelompok Pengajian Nurul Huda Kelurahan Kotabaru Kecamatan Tanjung Karang Timur Bandar Lampung termasuk ekonomi sedang. Dimana rata – rata latar belakang pendidikan kelompok pengajian ini umumnya hanya tamatan SMP dan SMA namun ada juga yang Sarjana. Tujuan dari kegiatan ini adalah Meningkatkan pengetahuan dan ketrampilan kelompok Pengajian Nurul Huda Kelurahan Kotabaru mengenai keamanan pangan, pembuatan dodol labu siam, sanitasi dan higiene analisis usaha pembuatan diversifikasi produk olahan labu siam yaitu dodol labu siam. Kegiatan ini diharapkan dapat memberikan manfaat bagi : Universitas lampung, yaitu sebagai sarana untuk menyebarkan ilmu pengetahuan dan teknologi dalam upaya memberikan sumbangan bagi pelaksanaan pembangunan sedangkan untuk kelompok Pengajian Nurul Huda Kelurahan Kotabaru, yaitu sebagai sarana untuk meningkatkan pengetahuan dalam membuat diversifikasi produk olahan labu siam (dodol labu siam)
PEMANFAATAN ZOOM MEETING SEBAGAI MEDIA EDUKASI COVID-19 BAGI KAUM MILENIAL
Authors: Sari Ifit Novita , Alfiansya Muhammad Zunizar , Ilmi Akhmad Miftakhul , Abdillah Ilham Fikri
Published: April 2022

Pandemi virus Corona yang melanda telah banyak menyebabkan perubahan dinamika sosial pada masyarakat dunia. Perubahan yang ada pada masyarakat banyak mempengaruhi aspek kehidupan secara drastis. Kelangsungan hidup masyarakat harus terus berjalan agar tetap kondusif. Generasi muda merupakan salah satu garda terdepan yang perlu di edukasi agar bisa cepat menyesuaikan diri dengan perubahan. Penggunaan media sosial atau platform berbasis online sangat dibutuhkan dalam mengedukasi terkait Covid-19 dan segala dampak juga penanggulangannya. Kaum milenial menjadi tujuan utama untuk di edukasi karena mereka adalah calon penggerak bangsa untuk hari esok.
EDUKASI VAKSIN COVID-19 PADA MASYARAKAT MELALUI MEDIA SOSIAL
Authors: Kamri Andi Maulana , Rahmawati Rahmawati , Hasan Murniati , Riski Filla , La Dongke Asrul , Resky Batary , Lestari Ayu , Nuraenun Nuraenun , Precyllia Nindy , Nurfadillah Nurfadillah , Istikamah Indira , Pertiwi Suci , Ali Muhammad , Rahma Nur
Published: April 2022

Pengetahuan tentang penyakit di masa modern ini sangat mudah untuk diakses oleh masyarakat awam dengan adanya internet, sehingga membuat masyarakat Sebagian kehidupannya akan bersentuhan dengan dunia maya. Namun, tidak sedikit informasi yang didapatkan keliru atau tidak lengkap. Maka dari itu, kami ingin memberikan edukasi kepada masyarakat di masa pandemi ini pengetahuan tentang vaksin agar masyarakat lebih mengenal vaksin dengan media yang lebih familiar. Metode yang kami gunakan adalah visual instrument menggunakan video dan leaflet yang disebarkan melalui media social seperti instagram, facebook, hingga youtube. Hasil menunjukkan bahwa ternyata informasi edukasi media social dapat meningkatkan pemahaman dan mempengaruhi perspektif masyarakat awam dalam menilai vaksin di tengah maraknya informasi yang tidak jelas. Hal ini terlihat bahwa ternyata 98.8% responden merasa bahwa informasi yang didapatkan melalui program edukasi ini menjadi sumber informasi baru dan update untuk mereka dibandingkan pengetahuan awal yang mereka yakini sudah benar. Pemberian informasi edukasi melalui social media dapat meningkatkan pemahaman mandiri masyarakat di masa pandemi.
Pemberdayaan Manajemen Workey “Wash or Keep Away” Dalam Meningkatkan Protokol Kesehatan Ibu dan Anak Petani Saat Menghadapi Pandemi Covid-19 di Desa Ria-Ria
Authors: Kaban Febri Oktavinola , Nasution Diah Lestari , Siregar Farida Linda Sari
Published: April 2022

Pengabdian ini akan dilakukan pada petani yang berprofesi sebagai petani di daerah Humbang Hasundutan. Permasalahan yang terjadi adalah tingginya angka covid-19 yang sangat meresahkan masyarakat dalam beberapa tahun ini. Sehingga harus melakukan pemberdayaan kepada petani agar mampu meningkatkan kualitas kesehatan. Untuk itu pengabdi menawarkan pengaturan manajemen WORKEY (wash or keep away) pada petani dengan melakukan step by step protocol Kesehatan. Solusi dalam pengabdian ini adalah memberikan edukasi dalam pengaturan petani dalam meningkatkan protocol Kesehatan saat pandemic covid-19. Target luaran dalam kegiatan ini adalah jurnal pengabdian, media cetak, video kegiatan dan jasa. Tujuan kegiatan ini adalah memberikan edukasi dan penerapan secara mandiri dalam mengatur meningkatkan protocol Kesehatan saat pandemic covid-19
PENINGKATAN KAPASITAS APARATUR DAN KADER PEMBANGUNAN PEREMPUAN DALAM RANGKA PEMBENTUKAN RUANG PUBLIK INKLUSIF DI DESA MERAK BELANTUNG LAMPUNG SELATAN
Authors: Meiliyana Meiliyana , Caturiani Susana Indriyati , Ali Suprihantin
Published: April 2022

Masyarakat yang tinggal di suatu wilayah membutuhkan ruang publik yang inklusif.  Melalui ruang publik tersebut masyarakat yang memiliki  berbagai karakteristik latar belakang seperti etnis, usia, dan jenis kelamin, dapat saling berinteraksi juga memberikan ruang bagi anak-anak serta mereka yang berkebutuhan khusus atau difabel.Berbagai penelitian menunjukkan bahwa ruang publik berdampak pada kesehatan mental, fisik dan hubungan sosial masyarakat. Namun akses ke ruang terbuka publik masih belum nyaman dana man bagi sebagian kelompok masyarakat. Hal ini disebabkan oleh desain yang belum mewadahi kebutuhan kelompok masyarakat tersebut. Kelompok masyarakat tersebut khususnya adalah kaum difabel, para lanjut usia, anak-anak dan kaum perempuan.Ruang terbuka ini tidak hanya diperlukan di daerah perkotaan tapi juga perlu dibuat di daerah perdesaan. Kesehatan mental dibutuhkan oleh masyarakat yang tinggal di perkotaan pun di perdesaan. Perwujudan ruang publik yang inklusif memerlukan keterlibatan/partisipasi semua pihak. Mereka adalah aparatur desa dan stakeholders terkait yang merupakan targeted groups terutama kaum perempuan.Kegiatan ini bertujuan untuk memberikan pemahaman dan meningkatkan pemahaman aparatur desa dan penggiat pembangunan di masyarakat Desa Merak Belantung, Kabupaten Lampung Selatan tentang pentingnya ruang publik yang inklusif serta mencoba memetakan kesempatan dan tantangan untuk mewujudkan keberadaan ruang terbuka publik ini.
ANALISIS DAMPAK PEMBANGUNAN JALAN TOL TRANS SUMATERA (JTTS) RUAS TERBANGGI BESAR-GUNUNG SUGIH TERHADAP USAHA RUMAH MAKAN DAN USAHA MIKRO KECIL MENENGAH (UMKM)
Authors: Irfan Ahmad , Rosalia Feni , Maryanah Tabah
Published: April 2022

The JTTS development policy for the Terbanggi Besar-Gunung Sugih section had both positive and negative impacts. This research is aresearch mix method combining quantitative and qualitative. Respondents in the study were 30 restaurant and UMKM business actors selling souvenirs and vehicle repair shops, as well as 10 new business actors who emerged using purposive sampling technique. The results showed that the restaurant and UMKM sellers of souvenirs and vehicle repair shops experienced a significant decrease in income after the existence of JTTS. Meanwhile, the exit toll at Terbanggi Besar has experienced quite rapid growth in new businesses. Based on the statistical test (1) Development JTTS significant effect on the reduction in income the restaurant business and SMEs sellers of souvenirs and vehicle repair shop on the street Central Crossing Sumatra from exit toll roadTerbanggi Besar to exit the toll Mount Sugih with  valuet for 8435 is greater than > 2,048 with an influence of 71.8%. (2) Development JTTS significant effect on the growth of new businesses are emerging withtvaluethe for 8222 is greater than> 2.306 with the effect of 89.4%. (3) Alternative policies for reducing the income of souvenirs-selling restaurants and SMEs as well as vehicle repair shops are: (a) The Government promotion by giving directions culinary region before the exit tollMount Sugih and exit motorwayGreat Terbanggi. (b) For the vehicle repair business, an alternative policy can be adopted for the convenience of obtaining people's business credit (KUR) through a number of banks. Meanwhile, an alternative policy for new business growth that has emerged is the use of exit the Terbanggi Besar toll roadto build a special location for selling.
ANALISIS PENDAPATAN ASLI DAERAH, DANA BAGI HASIL, DAN JUMLAH PENDUDUK TERHADAP BELANJA DAERAH DI PROVINSI SUMATERA BARAT
Authors: Fajriati Mia , Zulfatunnisa Zulfatunnisa , Wafa Dinar Rifatul , Heryaningrum Rika Amanda , Anwar Saiful
Published: April 2022

Regional spending aims to prosper the community and advance the region, when regional income increases, the region will be more capable and independent to finance regional expenditures. This study aims to determine the effect of Regional Original Income, Revenue Sharing Funds and Total Population on Regional Expenditures. The population of this study is the Regency and City in West Sumatra Province. The sampling methode uses quantitative methods with analytical techniques in the form of panel data regression analysis. The results of this study indicate that the Regional Original Revenue  has a significant positive effect on Regional Expenditure, while the Revenue Sharing Fund has a positive and significant effect, and the Number of Population has an insignificant negative effect. It is hoped that this research can be a reference in further research. It is hoped that this research can be a reference for the government to better utilize existing resources in order to prosper the community and better optimize the use of local revenue, regional expenditure funds, and profit-sharing funds.
A Survey of Occupational Inhalation Exposures to Propylene Oxide during Production and Use Operations in support of REACH registration/Erhebung über die berufsbedingte Inhalationsexposition gegenüber Propylenoxid bei Produktions- und Verwendungsvorgängen zur Unterstützung der REACH-Registrierung
Authors: Morgott David , Stewart Charln , Smet Karen , Fink Kristin , Epure Mihaela , Noij Dook , Gimeno Cortés Maria José , Urbanus Jan
Published: April 2022

As an adjunct to the chemical safety assessments mandated under the REACH legislation (REACH: Registration, Evaluation, Authorisation of Chemicals) a measurement survey was conducted to collect and document personal exposures associated with the production and downstream use of propylene oxide. Using existing company in-house exposure monitoring capability short-term and long-term levels were obtained for employees from seven European production facilities which fell into one of six exposure groups: production operator, intermediate operator, product sampling, shipping (loading of train, truck, and ships or barges), equipment maintenance, and laboratory analysis. A total of approximately 200 personal exposure samples were collected over a period lasting from April 2013 to July 2014. The measurements were supplemented with approximately 50 archival measurements collected over a ten-year period from 1997 to 2007. The samples of the exposure values were analysed in a descriptive way. Exclusion criteria for sample quality were applied and absolute numerical values replaced left censored non-quantified measurements. The limits of quantification ranged between 0.02 mg/m3 and 23.0 mg/m3. Upper bounds of 95%-intervals for the mean values of the samples ranged from 0.20 mg/m3 to 1.96 mg/m3. Mean values were not calculated for the samples of the product sampling and equipment maintenance personnel since all measurements were below the respective limits of quantification. A majority of the amassed short-term samples were collected with shipping personnel who displayed a high degree of exposure variability with concentrations ranging as high as 168.3 mg/m3. A limited number of short-term samples were also collected in other exposure groups such as product sampling and laboratory analysis where the levels were below the respective limits of quantification. The exposure survey results provide a reasonable basis for use in chemical registration under REACH.
Gemeinsam noch effizienter
Authors: Schmidt Maximilian
Published: April 2022

Sowohl im Haus- und Wohnungsbau als auch im industriellen und gewerblichen Bereich spielt der Einsatz von erneuerbaren Energien für Heizung, Kühlung und Warmwasser eine immer wichtigere Rolle. Dies gilt vor allem mit Blick auf den Umweltschutz sowie auf bestehende Fördermöglichkeiten. Zunehmend häufiger kommen deshalb Wärmepumpen zum Einsatz, die zusätzlich auch den Kühlbetrieb unterstützen. Um größere, parallele oder stark schwankende Leistungsanforderungen möglichst effizient und sicher zu decken, bietet sich eine Wärmepumpenkaskade an.
Überarbeitete Lüftungsnorm vereinfacht Planung und Anwendung von zentralen Lüftungssystemen
Authors: Geithe Oliver
Published: April 2022

Die sogenannte „Lüftungsnorm“ ist für Baubeteiligte in den vergangenen Jahren immer mehr zu einer fundamentalen Planungshilfe geworden. Die aktuelle DIN 1946–6:2019–12 trägt dieser Rolle nun Rechnung, indem sie einige wichtige Änderungen mit sich bringt – Änderungen, welche zehn Jahre nach der letzten Überarbeitung längst überfällig waren und welche aktuellen Entwicklungen, sowohl in der Bauweise von Gebäuden als auch in der Lüftungstechnik an sich, einbeziehen.
Assessment of accountability in state regulation of Arctic zone of the Russian Federation in current institutional environment.
Authors:   Saint Petersburg Mining University, Kirsanova Natalia Y. , Lenkovets Olga M. ,   Saint Petersburg Mining University
Published: April 2022

The article analyzes the role of state regulation in harmonization of the socio-economic interest system in the Arctic Zone of Russian Federation (AZRF) in the current institutional environment. Research and development of new institutions, forms of economic behavior in AZRF are especially topical in the new economic reality. They play an important role in ensuring energy and national security, which leads to increased attention to the pace and quality of the region development. The interdisciplinary management approach is required for AZRF development, because it covers social, economic, and environmental factors. The study has proven that the regional industry and transport development leads to a complex system of contradictory socio-economic interests: business, state and local population, including indigenous peoples. AZRF development effects are ranked by the degree of economic relation participants’ interests. The socio- economic interest system is analyzed. According to the authors, the general trend of AZRF development in the near future will greatly depend on accountability that the state assumes for the results of the region development, which requires tightening the institutional conditions of economic management and developing a new economic model. The study results can be used to justify the public policy in the elaboration of strategies for AZRF development.
The Northern and Arctic specifics of solving the problem of food security.
Authors:   Institute of Socio-Economic and Energy Problems of the North of the Komi Research Center of the Ural Branch of the Russian Academy of Sciences, Ivanov Valentin A.
Published: April 2022

The results of scientific research on the features and priority areas of strengthening food security of the population of the northern and Arctic territories are presented. The theoretical and methodological basis was the works of scientists in the field of food security. Analytical and statistical methods, methods of analogies, and expert assessments were used. The sources of information were data on the socio-economic development of the regions of the Far North and areas equated to them, Unified Interdepartmental Information and Statistical System (EMISS), Comistat, scientific publications on the research topic. The constituent elements of food security at the country and regional levels have been identified. Approaches to solving food security in the countries of the world are considered. The assessment of the state of food independence of Russia is given. The features, risks and threats to food security in extreme living conditions associated with the destruction of the material base of agriculture, the shortage of qualified personnel in the industry, the degradation and underdevelopment of rural infrastructure, the transport inadmissibility of remote areas for guaranteed food supply to their population, the decrease in food safety and quality, the inaccessibility of the poor to high-quality and safe food in accordance with rational consumption standards, the imperfection of regulatory and legal regulation and the organization of control over the quality and safety of food. The priority directions of ensuring food security are substantiated, including increasing own agricultural production, improving interregional links of food supplies to the regions of the North and the Arctic, improving the demographic situation, developing transport and trade infrastructures in rural areas, improving regulatory and legal regulation in the field of food safety and reducing rural poverty. The new approach to food security, which differs from the traditional one, is the sustainable development of rural areas, the creation of favorable living conditions for their population, and the reduction of poverty. Recommendations and suggestions can be used in the development of directions for improving state policy to strengthen food security of the population of the North and Arctic zone, as well as in the further research work of the author.
The efficacy and safety of neuromodulation in refractory epilepsy: a systematic review and network meta-analysis
Authors:   Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing,China, Xin Wu , Tao Xue
Published: April 2022

Review question / Objective: To assess the efficacy and safety of different neuromodulation applied to the refractory epilepsy and provide a better choice for clinical practice. Condition being studied: Epilepsy is a frequent neurologic illness defined by bursts of hypersynchronized neural network activity that afflict about 1% of the global population. Unfortunately, roughly 30% of people with drug-resistant epilepsy (DRE) continue to experience seizures despite three anti-seizure drugs. In most cases, resective surgery, as the first-line treatment for DRE, is considered a curative therapy for achieving long-term seizure-free status, but about half of patients are not candidates for surgery due to a variety of factors such as multiple/diffuse/widespread seizure foci, epileptic foci arising from eloquent, primary generalized epilepsy, or patients unwilling to undergo surgery. Neuromodulation, albeit palliative, is an important alternative treatment for these individuals to prevent or decrease ictal episodes, which can affect the nervous system in a variety of ways.
Elevated levels of pleiotropic interleukin-6 (IL-6) and interleukin-10 (IL-10) are critically involved with the severity and mortality of COVID-19: An updated longitudinal meta-analysis and systematic review on 147 studies
Authors:   Noakhali Science and Technology University, Jafrin Sarah , Aziz Md. Abdul , Islam Mohammad Safiqul
Published: April 2022

Review question / Objective: How were serum IL-6 and IL-10 linked with the severity and mortality of COVID-19 patients? To evaluate the role of IL-6 and IL-10 in the development of the severity or morality of COVID-19 patients. The outcomes (mean difference) were calculated between the severe vs. non-severe COVID-19 patients and non-survival vs. survival patients to evaluate the risk of severity or mortality. Condition being studied: Severity and mortality among the COVID-19 patients. Information sources: The international scientific authorized databases such as Google Scholar, PubMed, Embase, CNKI, Cochrane Library, and Web of science were used as primary sources to identify and collect the eligible literature. Additional secondary databases were also comprehensively searched to extract more related studies.
VALENCENE, A SESQUITERPENE EXHIBITS ANTILIPID PEROXIDATION AND ANTIOXIDANT EFFECTS IN THE PLASMA OF ISOPROTERENOLINDUCED MYOCARDIAL INFARCTED RATS
Authors:   Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore-641 114,Tamil Nadu,South India., Shervin Prince S , Berlin Grace V.M ,   Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore-641 114,Tamil Nadu,South India.
Published: April 2022

Aim: The present study was aimed to evaluate the effects of valencene, a sesquiterpene on plasma lipid peroxidation and antioxidants in isoproterenol-induced myocardial infarcted rats. Methods: Rats were induced myocardial infarction by isoproterenol (100 mg/kg body weight) on the 1st and 2nd day and then on the 4th-day valencene treatment was given to rats orally, daily, for 14 days. Results: Isoproterenol-induced myocardial rats showed an increase in the levels of serum myoglobin, plasma thiobarbituric acid reactive substances, and lipid hydroperoxides and a significant decrease in the levels of plasma non-enzymatic antioxidants such as reduced glutathione, vitamin- C, and vitamin-E. Oral treatment with valencene (12 mg/kg/body weight) daily for 14 days significantly reduced serum myoglobin and plasma lipid peroxidation and significantly increased non-enzymatic antioxidants. Conclusion: Thus this study reveals the anti-lipid peroxidation and antioxidant effects of valencene in isoproterenol-induced myocardial infarcted rats.
THE IMPORTANCE OF AFTER-SALES ACTIVITIES IN THE MARKETING OF MEDICAL PRODUCTS THROUGH PUBLIC PROCUREMENT
Authors:   Professor, International School for Social and Business Studies, Mariborska cesta 7, 3000 Celje, Slovenia and University of Primorska, Faculty of Management, Izolska vrata 2, SI- 6000 Koper, Slovenia, Vukasović Tina , Sluga Anita ,   VenoFarmacija d.o.o., Ul. I štajerskega bataljona 7, SI-3000 Celje, Slovenia
Published: April 2022

The purpose of the paper is to contribute to the knowledge in the field of marketing of medical devices in the public sector. A quantitative research method was used by means of a structured questionnaire. The target population of research is employed in laboratories in health centers and hospitals. We have obtained a sample of 208 respondents employed in these institutions. By conducting statistical analyses, we found that all the studied variables are in a positive correlation with each other and that the “Personal Sales” variable is equally important in the marketing of medical devices to social welfare institutions through public procurement as the “After-Sales Activities” variable. The research is based on the results obtained in a narrow segment of the medical products market, which makes them useful with a high degree of reliability only in this product group. For the purpose of comparability, the results may be used within the field of medical products, and in so doing we have to take into account the specificity of medical products and the medical industry. The newly designed structural model of correlations between the studied elements, represents a new value both in the field of scientific research work as well as in the field of usability in practice. The research is a contribution to the fact that in the process of marketing products through public procurement, the same attention is devoted to the after-sales activities as to the design and development of new products, planning of marketing channels (distribution), marketing communication (promotion) and pricing
Mixed Convection in a Lid-Driven Horizontal Rectangular Cavity Filled with Hybrid Nanofluid by Finite Volume Method
Authors: I. R. Ali  , Ammar I. Alsabery  , Norhaliza Abu Bakar  , Rozaini Roslan
Published: April 2022

In the present work, a new type of nanofluid called the hybrid nanofluid (Al2O3-Cu-water) is used to enhance the heat transfer. The Finite-Volume-Method (FVM) along with the SIMPLE-algorithm has been utilized to study the heat-transfer and, mixed convection fluid-flow of the hybrid nanofluid (Al2O3-Cu-water), placed within the lid-driven rectangular cavity. The bottom and top walls are subjected to constant high temperature (Th) and low temperature (Tc) respectively. The side walls are treated as adiabatic. The top wall moves in the positive x-direction. The effects of Reynolds number and hybrid nanoparticle volume fraction on the flow field have been investigated. It is found that the mean Nusselt number increases with respect to Reynolds numbers and hybrid nanoparticle volume fraction.
Drying Performance of Piper Nigrum in a Swirling Fluidized Bed Dryer: An Experimental Study
Authors: Nur Fatihah Mohd Roslan  , Ahmmad Shukrie Md Yudin  , Muhammad Afiq Sumono  , Muhammad Faris Mohamad Pozi  , Muhammad Aidil Safuan Othman
Published: April 2022

Sun drying is widely used in drying agricultural products such as piper nigrum because of its ability to dry a high volume in one batch. However, this conventional method of drying has many disadvantages, especially on the hygienic issue. This study investigates the drying performance of piper nigrum by using conventional sun drying and a new dryer called Swirling Fluidized Bed Dryer. Swirling fluidized bed dryer is operated using two inclination angles of air distributors, namely 45°, 67° and one perforated plate distributor. The drying performance is accessed in terms of drying time and moisture content reduction at three different operating temperatures. The results show that the drying time of piper nigrum using a swirling fluidized bed dryer is reduced as compared to conventional sun drying. Besides, the drying performance between different distributors in swirling fluidized bed shows that the moisture content reduction of piper nigrum using 45° angle of air distributor shows the most reduction compared to 67° angle distributor and followed by the perforated distributor. In conclusion, results show that the drying of piper nigrum in a swirling fluidized bed operated with 45° inclination angle of the distributor at high operating temperature gives the best performance.
Techno-Economic Analysis of Wind Energy Potential in North-Eastern of Thailand
Authors: Natthapat Pawintanathon  , Somchai Saeung  , Juntakan Taweekun
Published: April 2022

Thailand's alternative power development plan attempts to reduce the dependence of electrical power generation on fossil fuels by setting a goal of generating electricity from wind energy resources of 3,002MW within year 2,036. Moreover, the shortage of electricity in the North-eastern region of Thailand needs to be cared for to create stability of energy in Thailand. Therefore, the assessment of wind power resource potential in the north-eastern part of Thailand needs to be studied. This paper presents a technical and economic analysis of the wind power potential for five stations in the north-eastern part of Thailand: Buriram, Roi Et, Sri Sa Ket, Surin, and Ubon Ratchathani within 4 years (2017-2020) at a 10-minute interval. The data was collected from Thai Meteorological Department (TMD) at a 10m height above ground level. This paper focuses on the wind climate at 60m and 80m above ground level by using WAsP to simulate the mean wind speed and power density of each station. Moreover, this study uses Vestas V52-850kW and Vestas V90-2,000kW wind turbine generators to calculate the net annual energy production of each station. In addition to evaluating the economic analysis of investment, this study uses economic tools to evaluate the feasibility of investment. The result showed that Roi Et is the most suitable location for a wind farm. The mean wind speeds and power densities are 5.95 m/s and 265 W/m2 at 60m and 6.15 m/s and 311 W/m2 at 80m. The AEP can be generated at 18.932 GWh and 56.322 GWh at 60m and 80m heights respectively for Roi Et with a cost per unit of 0.09 $/kWh and 0.07 $/kWh. The other provinces have an AEP of 10.674 GWh for Buriram, 12.152 GWh for Sri Sa Ket, 12.969 GWh for Surin, and 8.508 GWh for Ubon Ratchathani at 60m height level, with a cost per unit of 0.15 $/kWh, 0.14 $/kWh, 0.13 $/kWh, and 0.2 $/kWh respectively. At 80m height, the AEP is 33.437 GWh with 0.11 $/kWh for Buriram, 45.737 GWh with 0.09 $/kWh for Sri Sa Kat, 41.189 GWh with 0.09 $/kWh for Surin, and 27.524 GWh with 0.14 $/kWh for Ubon Ratchathani.
Developmental Hypothyroidism Influences the Development of the Entorhinal-Dentate Gyrus Pathway of Rat Offspring
Authors: Jin Ting , Wang Ranran , Peng Shiqiao , Liu Xin , Zhang Hanyi , He Xue , Teng Weiping , Teng Xiaochun
Published: April 2022

Background: Developmental hypothyroidism impairs learning and memory in offspring, which depend on extensive neuronal circuits in the entorhinal cortex, together with the hippocampus and neocortex. The entorhinal-dentate gyrus pathway is the main entrance of memory circuits. We investigated whether developmental hypothyroidism impaired the morphological development of the entorhinal-dentate gyrus pathway.Methods: We examined the structure and function of the entorhinal-dentate gyrus pathway in response to developmental hypothyroidism induced using 2-mercapto-1-methylimidazole.Results: 1,1´-Dioctadecyl-3,3,3´,3´-tetramethylindocarbocyanine perchlorate tract tracing indicated that entorhinal axons showed delayed growth in reaching the outer molecular layer of the dentate gyrus at postnatal days 2 and 4 in hypothyroid conditions. The proportion of fibers in the outer molecular layer was significantly smaller in the hypothyroid group than in the euthyroid group at postnatal day 4. At postnatal day 10, the pathway showed a layer-specific distribution in the outer molecular layer, similar to the euthyroid group. However, the projected area of entorhinal axons was smaller in the hypothyroid group than in the euthyroid group. An electrophysiological examination showed that hypothyroidism impaired the long-term potentiation of the perforant and the cornu ammonis 3–cornu ammonis 1 pathways. Many repulsive axon guidance molecules were involved in the formation of the entorhinaldentate gyrus pathway. The hypothyroid group had higher levels of erythropoietin-producing hepatocyte ligand A3 and semaphorin 3A than the euthyroid group.Conclusion: We demonstrated that developmental hypothyroidism might influence the development of the entorhinal-dentate gyrus pathway, contributing to impaired long-term potentiation. These findings improve our understanding of neural mechanisms for memory function.
AUTOMATIC SAFETY EVALUATION AND VISUALIZATION OF SUBWAY STATION EXCAVATION BASED ON BIM-FEM/FDM INTEGRATED TECHNOLOGY
Authors: Xie Ping , Zhang Rongjun , Zheng Junjie , Li Ziqian
Published: April 2022

With the progressive promotion of BIM technology in collaborative design and engineering data management, there are large amounts of project information available for intelligent construction, engineering computation and design optimization. In the construction of subway station, BIM technology is still not mature and the engineering design is generally separate from the engineering safety evaluation. Thus, this paper proposed a technology that integrates BIM and numerical simulation (BIM-FEM/FDM integrated technology) to solve the problem of separation between engineering design and computation. A three-dimensional parametric modeling of subway station excavation was first carried out using the Revit® modeling software. Afterward, a FEM/FDM-process oriented data conversion interface was developed to extract and process the critical information from the parametric BIM model for numerical simulation. Then, under the impetus of an auto-simulation interface, the safety evaluation of subway station excavation was realized automatically and visualized graphically. The research of the BIM-FEM/FDM integrated technology presented in this paper has established a supporting platform to achieve the integration of BIM-based design and safety evaluation for subway station excavation.
Ancestral Black Holes of Binary Merger GW190521
Authors: Barrera O. , Bartos I.
Published: April 2022

GW190521 was the most massive black hole merger discovered by LIGO/Virgo so far, with masses in tension with stellar evolution models. A possible explanation of such heavy black holes is that they themselves are the remnants of previous mergers of lighter black holes. Here we estimate the masses of the ancestral black holes of GW190521, assuming it is the end product of previous mergers. We find that the heaviest parental black holes has a mass of

56

−
18

+
20

M
⊙ (90% credible level). We find 70% probability that it is in the 50 M
⊙–120 M
⊙ mass gap, indicating that it may also be the end product of a previous merger. We therefore also compute the expected mass distributions of the “grandparent” black holes of GW190521, assuming they existed. Ancestral black hole masses could represent an additional puzzle piece in identifying the origin of LIGO/Virgo/KAGRA’s heaviest black holes.
Blended Motor-Sensory Nerve Bundles on Diffused Tensor Imaging: Evidence of Brain Plasticity in a Patient with 36-year Sequelae from Encephalitis
Authors: Lam Khanh , Nguyen Pham Thanh , Anh Lam Viet , Lien Tran
Published: April 2022

BACKGROUND: Brain plasticity refers to the extraordinary ability of the brain to modify its structure and function following changes within the body or in the external environment. However, it is not easy to find it on non-invasive imaging modality.
CASE REPORT: In this article, we report the case of a 36-year-old male patient with sequelae of encephalitis. The patient had general epilepsy with multiple hospital admissions. MRI 3.0 Tesla showed his cerebral hemispheres were asymmetrical both morphologically and tractographically; there was a scar at the right temporo-occipital region, and an atrophy of the right temporal lobe, hippocampus and pontine. DTI reconstruction showed asymmetrical cortico-spinal and thalamo-cortical tracts with posterior thalamo-cortical tract was partly damaged by the scar. Blended motor-sensory nerve bundles were observed only on the left side of the patient’s brain but not on the right or healthy subjects. DTI quantification showed the lower line number, lower FA and higher ADC in the patient compared to healthy subjects and within the patient with decreased functionality on the side of the scar.
CONCLUSION: Non-invasive DTI with 3D image reconstruction on the patient showed evidence of brain plasticity appeared on cortico-spinal and thalamo-cortical tracts and can inform diagnosis and treatment strategies.
Environmental citizen science in Greece: perceptions and attitudes of key actors
Authors: Galanos Chrysostomos , Vogiatzakis Ioannis N.
Published: April 2022

Citizen Science (CS), the voluntary participation of lay people in scientific work, is well-established in the fields of nature conservation and biodiversity monitoring due to its potential to create large environmental datasets. This study aims to understand the familiarity, perceptions and attitudes towards CS of the key environmental actors in Greece. The target group consisted of employees and/or representatives of Environmental Non-Governmental Organisations (ENGOs), scientists and civil servants related to nature conservation. Quantitative data were collected using an electronic questionnaire, 178 fully completed questionnaires and subsequently eight semi-structured interviews with experts were conducted. Descriptive statistics were used to measure the familiarity and attitude of the actors, as well as the obstacles to the development of CS in Greece. We used Cronbach’s test to measure the reliability of the used Likert scale and Kruskal-Wallis non-parametric test to identify significant differences amongst the three groups of actors. Qualitative data were analysed following a Thematic Analysis methodology. The results show that ca. 40% of the key actors are familiar with the terms and CS practice while over 65% with the concept. The general attitude of the actors towards CS is positive although concerns about data quality collected were highlighted. “Lack of cooperation culture”, “Ignorance of the existence of the phenomenon” and “Lack of know-how” emerged as the most important obstacles to CS development in Greece. Although CS is present in Greece, it is not visible enough. The main reasons are that relevant projects employ different terms, are under-represented in the formal literature and include limited, if at all, project dissemination. There are significant differences regarding familiarity and the attitude towards CS between actors, but also similarities concerning the main obstacles. The study sets a baseline which can be employed to improve and further expand Environmental Citizen Science (ECS) in Greece.
The use of complex marketing analysis and QSPR methodology for the necessity of a drug development grounding for the treatment of type 2 diabetes mellitus with increased bioavailability
Authors: Kovalevska Inna , Ruban Olena , Volkova Alina , Kotvitska Alla , Cherkashyna Alina
Published: April 2022

In order to guarantee qualitative medical and pharmaceutical care it is necessary for all participants of the process to provide consistent interconnected actions, including the use of modern approaches in pharmacotherapy, assessment of the urgent needs of the population in medicines (drugs), development and introduction of modern qualitative, safe and effective drugs into the market. Today, one of the key indicators in determining the population‘s need for drugs is the epidemiological indicators in a particular region and their dynamics.

In recent years, the actuality of optimal and effective approaches developing in the prevention and treatment of socially significant diseases, including diabetes mellitus (DM), has been increasingly emphasized at the global level. All actions that are proposed for the development of standardized guidelines, treatment protocols, programs for on-time detection and prevention of diabetes are aimed at forming a system of measures are patient-oriented, based on understanding the patient‘s problems, lifestyle, habits, income and expenses for treatment, as well as other components associated with achieving optimal results for patients.
Les extrêmes droites européennes depuis 1945 dans les fonds de La contemporaine
Authors: Bouchery Dominique
Published: April 2022

Les extrêmes droites ne sont pas le courant politique le plus représenté dans les collections de La contemporaine, à fortiori dans la période après 1945. Pour autant, un tour d’horizon approfondi dans les divers types de fonds (archives, imprimés, affiches, collections audiovisuelles) permet de constater que de nombreuses sources s’offrent au chercheur, et que c’est justement leur croisement qui permet de multiplier les angles d’approche et les problématiques.
Le CID(-UNATI), un syndicat « subversif » (1968-1974) ?
Authors: Muller Bryan
Published: April 2022

Syndicat d’artisans et de petits commerçants de tendance néo-poujadiste, le Comité d’information et de défense (CID) de Gérard Nicoud se rend célèbre pour ses nombreuses activités spectaculaires dans les années 1968. La peur du déclassement social entraîne le syndicat dans une dérive d’actions violentes qui inquiètent les autorités. Le CID (bientôt renommé CID-UNATI à la suite d’une fusion avec un autre syndicat) en vient à interroger ses contemporains : s’agiraitil d’un syndicat « subversif » ?
Pierre Grappin, Mémoires d’un universitaire humaniste , Presses Universitaires de Paris Nanterre, 2020, 378 p.
Authors: Pailhès Anne-Marie
Published: April 2022

Le cinquantenaire de 1968 a donné lieu à cette réédition des mémoires de Pierre Grappin, germaniste et Doyen de l’université au moment des événements. L’ouvrage est agrémenté d’une préface de Daniel Cohn-Bendit et d’un cahier de documents originaux issus du fonds Grappin conservé à La contemporaine.
Exequatur à « toutes fins utiles » d’une sentence arbitrale rendue à l’étranger dans le contexte d’une procédure collective ouverte en France
Authors: Farnoux Étienne
Published: April 2022

L’exequatur ne saurait, sans méconnaître le principe d’arrêt des poursuites individuelles des créanciers, rendre exécutoire une condamnation du débiteur à paiement de sommes d’argent. L’exequatur peut être accordé dans le but, non de conférer à la sentence arbitrale la force exécutoire d’une décision de condamnation du débiteur, mais exclusivement de permettre au créancier de faire reconnaître son droit de créance.
L’action directe en matière d’assurances en droit européen : un contentieux toujours abondant
Authors: Gaudemet-Tallon Hélène
Published: April 2022

L’article 13 §2 du règlement 1215/2012, lu en combinaison avec l’article 11 §1 b) de ce même règlement, ne peut être invoqué par une société qui, en contrepartie des services rendus, a acquis la créance d’indemnités de l’assuré, quand bien même cette société n’exercerait pas une activité professionnelle dans le domaine de recouvrement desdites créances (2 e  esp.). Lorsque les règles protectrices de la partie faible en matière d’assurances ne sont pas applicables, mais seulement en ce cas, il est possible de recourir aux autres règles des règlements 44/2001 et 1215/2012 (1 re  et 2 e  esp.). Pour savoir si l’action directe contre l’assureur du responsable est recevable il convient de rechercher la loi applicable à cette action (v. la note).