bluuebunny/crossref_metadata_2025 huggingface dataset:
Axiological aspects of teaching Spanish in the Soviet Union
Authors: Novoselova E. V. , Chernova N. I. , Katakhova N. V.
Published: October 2022

Objectives. The paper analyzes core axiological aspects of Spanish teaching in higher educational institutions of the Soviet Union from the 1930s to the early 1980s based on various sources including textbooks, tutorials, etc. Methods. The study is based on textual-analytic, historical-comparative, and structural methods.

Results. Scientific-pedagogical and sociological aspects of the subject are distinguished. The former are limited to the internal developmental logic of Spanish studies, while the latter refers to external circumstances, including ideological factors. The literature review shows that Spanish teaching in the USSR progressed topically from simple manuals aimed at consolidating linguistic basics to a more rigorous pedagogical development of Spanish language studies (grammar, phonetics, vocabulary, etc.) The authors identify two significant periods in the development of Soviet Spanish studies, with the first phase extending from the 1930s to the early 1960s, and the second—from the 1960s to the early 1980s.

Conclusions. The analysis showed that the formation and development of each period is associated with such events as the Spanish Civil War and the victory of the Cuban Revolution, which are not directly related to Spanish teaching. The first event coincided with the beginning of systematic Spanish teaching at the USSR universities, while the second redirected this process from Castilian to Latin American Spanish. However, the analysis of textbook and tutorial materials convincingly demonstrates that this process of redirection, which mainly concerns the selection of textual materials, remains incomplete. This supports a conclusion concerning the limited impact of ideology on the internal logic of the Spanish studies development in the USSR.
3D object tracker for sports events
Authors: Volkova M. A. , Romanov M. P. , Bychkov A. M.
Published: October 2022

Objectives. Sports events are currently among the most promising areas for the application of tracking systems. In most cases, such systems are designed to track moving objects in a two-dimensional plane, e.g., players on the field, as well as to identify them by various features. However, as new sports such as drone racing are developed, the problem of determining the position of an object in a three-dimensional coordinate system becomes relevant. The aim of the present work was to develop algorithms and software for a method to perform 3D tracking of moving objects, regardless of the data segmentation technique, and to test this method to estimate the tracking quality.

Methods. A method for matching information on the speed and position of objects was selected based on a review and analysis of contemporary tracking methods.

Results. The structure of a set of algorithms comprising software for a moving-object tracker for sports events is proposed. Experimental studies were performed on the publicly available APIDIS dataset, where a MOTA metric of 0.858 was obtained. The flight of an FPV quadcopter along a track was also tracked according to the proposed dataset; the 3D path of the drone flight was reconstructed using the tracker data.

Conclusions. The results of the experimental studies, which demonstrated the feasibility of using the proposed method to track a quadcopter flight trajectory in a three-dimensional world coordinate system, is also showed that the method is suitable for tracking objects at sports events.
Technology for the creation of ferroelectric regular domain structures using interfering elastic waves
Authors: Krutov V. V. , Sigov A. S.
Published: October 2022

Objectives. In many laboratories around the world, work is underway in the field of domain engineering of ferroelectrics. For a number of years, RTU MIREA has been conducting research on the creation of a high-performance technology for the formation of ferroelectric photonic and phononic crystals. The technology is characterized by a short duration of the technological cycle and provides the necessary depth of spatially periodic domain inversion. The key element of the technology is the combined effect of a uniform electric field and interfering high-frequency elastic waves that create a temperature grating. The technology is universal in relation to ferroelectrics of varying degrees of acoustic transparency, which is achieved by using highly dissipative liquid electrodes of a certain thickness. In this case, the energy of elastic waves practically does not penetrate into the ferroelectric, so the manifestation of undesirable effects is excluded. The purpose of this review article is to analyze the results of work carried out at RTU MIREA in the field of technology for the formation of ferroelectric regular domain structures (RDSs) during the period from 2008 to the present.

Methods. Provisions of the theory of propagation, refraction and interference of elastic waves in condensed media are used, in particular, the Newtonian model of a liquid as applied to shear waves, as well as computer simulation. When considering the main stages of the Double Pulse heterothermal technology for the formation of RDSs, methods of analysis and synthesis were applied.

Results. The possibility of forming not only micro-, but also submicron RDSs is shown. Recommendations are given on the choice of the type and specific properties of liquid electrodes, the angles between the direction of propagation of interfering waves, and their frequency. It is shown, in particular, that the use of highly dissipative ionic liquids as liquid electrodes creates favorable conditions for the formation of an RDS with a short period at room temperature. Thus, on shear waves with electrodes based on LiPF6-PC at a frequency of 300 MHz, RDS with a period of about 2 цт can be created. The main technological parameters are determined both for the case of the action of longitudinal elastic waves and for the case of shear waves with horizontal polarization. The results are applicable to ferroelectrics such as lithium niobate, potassium titanyl phosphate, and lead zirconate titanate.

Conclusions. The proposed and studied methods are focused on the mass production of devices based on RDSs, in particular, on the manufacturing of optical parametric oscillators, acoustoelectronic devices, as well as terahertz wave generators and second harmonic oscillators. The technology has a short duration of the technological cycle, comparable to the polarization switching time in the used ferroelectric.
Rotasi Dan Mutasi Terhadap Kinerja Karyawan Universitas Flores
Authors: Helena Carolinda Dua Mea Maria
Published: October 2022

The goal of this study was to 1) determine the effect of rotation on the performance of University of Flores employees and 2) determine the effect of mutation on the performance of University of Flores employees. The sample size was 62 people, all of whom were permanent employees of the University of Flores. Questionnaires were distributed to gather data. SmartPLS Software is used to process data. The findings revealed that rotation had a positive (0.477>0) and significant (4.691>1.96) effect on employee performance at the University of Flores, while mutations had a positive (0.254>0) and significant (2.185>1.96) effect. Rotation and mutation influence the performance of University of Flores employees by up to 45 percent, with the remainder influenced by other variables not explained in this study.
Produtos Naturais em Fase Avançada de Testes Clínicos no Tratamento contra o Câncer
Authors: Souza M. V. N. , Pinheiro A. C. , Ferreira M. L. , Gonçalves R. S. B. , Lima Camilo H. da C.
Published: October 2022

Atualmente, os produtos naturais representam uma inestimável fonte de substâncias químicas tendo um importante papel no tratamento do câncer. Devido à importância da natureza como fonte de novos candidatos a fármacos no tratamento contra o câncer, o objetivo dessa revisão é enfocar os produtos naturais, que estão em fase avançada de testes clínicos e dentre em breve poderão ser introduzidos no mercado no combate ao câncer.
Família Lamiaceae: Importantes Óleos Essenciais com Ação Biológica e Antioxidante
Authors: Lima R. K. , Cardoso M. G.
Published: October 2022

Essa revisão teve como objetivo reunir artigos recentes sobre atividades biológicas de óleos essenciais de algumas plantas da família Lamiaceae, uma vez que o Brasil é rico em plantas desta família e estas são pouco estudadas. Entre as bioatividades relatadas estão: antioxidante, bactericida, fungicida e inseticida.
Історичні аспекти модернізації законодавства Німеччини щодо соціальної інтеграції осіб з інвалідністю
Authors: Zhorniak  A. M.
Published: October 2022

Основним показником розвитку будь-якої соціально-спрямованої держави є не лише економічне благополуччя населення, а й суспільне відношення до соціально незахищених категорій громадян, у тому числі до осіб з інвалідністю. На різних етапах становлення Німеччини як соціально-спрямованої держави ставлення до осіб з інвалідністю та їх сімей змінювалося від повного відчуження до створення інклюзивного суспільства, що знайшло своє відображення у законодавстві.
Метою статті є аналіз історичних передумов становлення сучасного законодавства щодо інтеграції осіб з інвалідністю у суспільно-політичне життя та побудови сучасного інклюзивного суспільства Німеччини.
Наукова новизна полягає у з’ясуванні теоретико-методологічних засад державної політики Німеччини щодо соціальної інтеграції осіб з інвалідністю шляхом аналізу наукових джерел; дослідженні особливостей державної політики щодо соціальної інтеграції цієї категорії громадян на основі ретроспективного аналізу німецького законодавства; узагальнення позитивного досвіду Німеччини стосовно державної політики щодо соціальної інтеграції осіб з інвалідністю.
Методологічну основу дослідження становить поєднання таких загальнонаукових, спеціальних і філософських методів, як: формально-логічний (проаналізовано ознаки, сутність та особливості держаної політики Німеччини щодо соціальної інтеграції осіб з інвалідністю); історико-правовий (з’ясовано питання становлення й розвитку законодавства про права інвалідів); формально-юридичний (проаналізовано норми німецького законодавства); cтатистичний (вивчено, проаналізовано й узагальнено інформацію щодо мети дослідження); аналітичний (визначено сутність, стан і проблеми державної політики Німеччини щодо осіб з інвалідністю); синтезу (виявлено організаційно-правові засади управлінської діяльності щодо соціальної інтеграції осіб з інвалідністю в Німеччині) тощо.
Висновки. У Німеччині було вжито комплекс спільних заходів для забезпечення впровадження практичних дій як з боку державних органів влади, законодавчих та виконавчих, так і з боку громадських інституцій, з метою удосконалення нормативно-правового підґрунтя сприяння соціальній інтеграції осіб з інвалідністю, розширення їх прав та можливостей для участі в житті громади, в обговоренні питань та прийнятті рішень на всіх рівнях, покращення суспільного ставлення до осіб з інвалідністю, забезпечення їх працевлаштування та кар’єрного розвитку.
Модель державно-релігійних відносин у Республіці Польща
Authors: Kotylko  Ya. M.
Published: October 2022

У статті здійснюється аналіз законодавства Республіки Польща з питань суспільно-релігійних відносин, розкриваються політичні та правові засади формування сучасної моделі державно-релігійних відносин та їх особливості. Досліджується вплив підписання Конкордату між Святим Престолом і Республікою Польща на польську Конституцію та нормативно-правові акти у сфері суспільно-релігійних відносин. Прослідковується еволюція поняття «світська держава» у законодавстві та рішеннях Конституційного Трибуналу Республіки Польща.
Метою статті є дослідження впливу Конкордату між Святим Престолом і Республікою Польща на національне законодавство Польської республіки та на відносини держави з Католицькою Церквою та іншими релігійними організаціями.
Наукова новизна полягає в тому, що підписання Конкордату між Святим Престолом і Республікою Польща розглядається не лише з точки зору конституційного і міжнародного права, а й через дотримання принципу рівності та недискримінації релігійних організацій.
Методологія дослідження: сукупність філософських, загальнонаукових та спеціально-правових методів, зокрема діалектичний, логіко-семантичний, структурно-функціональний та інші методи.
Висновки. Конкордат містить перелік прав, які надаються Католицькій Церкві з боку держави і гарантуються нею. Однак головною метою Конкордату є не стільки регулювання двосторонніх відносин Святого Престолу та держави, скільки визначення правового статусу та засад діяльності місцевої Католицької Церкви на території держави – учасниці цієї угоди. Для набуття чинності правових норм, що включені до Конкордату, Польща була змушена внести зміни до Конституції та ряду нормативно-правових актів. Ратифікація Конкордату призвела до ієрархізації релігійних організацій в Польщі та створення нової конвенційної (договірної) моделі державно-релігійних організацій, що ґрунтується на принципах індивідуального та диференційованого підходу до релігійних організацій.
Аналіз правового механізму забезпечення функціонування сучасної системи охорони здоров’я Німеччини
Authors: Lytovchenko  I. I.
Published: October 2022

Система забезпечення та функціонування охорони здоров’я в багатьох країнах Європи в різні часи зазнавала кількох втручань, оскільки була задумана на основі різних світоглядів, у соціальній та історичній конструкції, від простої концепції відсутності хвороби до широкої концепції з різними вимірами, такими як біологічні, поведінкові, соціальні, екологічні, політичні та економічні. Після другої світової війни в усьому світі була прийнята концепція Всесвітньої організації охорони здоров’я (ВООЗ), яка визначає «стан повного фізичного, психічного та соціального благополуччя, який не полягає лише у відсутності хвороби чи захворювання» [1].
Проте, на національному рівні Німеччини (з урахуванням міжнародного контенту) формується власний правовий механізм забезпечення функціонування системи охорони здоров’я, який є основою формування національної політики охорони здоров’я і функціонування системи в цілому.
Мета статті – дослідити і проаналізувати правовий механізм забезпечення функціонування сучасної системи охорони здоров’я Німеччини.
Наукова новизна полягає у подальшому розвитку дослідження правового механізму забезпечення впровадження сучасної політики охорони здоров'я і функціонування системи охорони здоров'я на основі чинного законодавства Федеральної Республіки Німеччина.
Методологія дослідження ґрунтується на загальнонаукових та спеціально-наукових методах, зокрема аналіз чинного законодавства Німеччини здійснювався за допомогою формальної логіки із застосуванням дедуктивного методу (аналізу) та індуктивного методу (синтезу); висновки сформульовані на основі системно-структурного аналізу та історико-правового, формально-логічного, формально-юридичного, діалектичного методів наукового пізнання.
Висновки. За результатами проведеного аналізу правового механізму забезпечення функціонування сучасної системи охорони здоров’я Німеччини встановлено, що всі правові аспекти соціального страхування поступово переносяться до Соціального кодексу (Sozialgesetzbuch (SGB)); федеральні землі мають власні законодавчі повноваження і несуть відповідальність за виконання федеральних законів; у ширшому розумінні галузь медичного права може включати, крім соціального права, лікарняне право, право про рятувальні служби, право про немедичні медичні професії, право про аптеки, ліки, медичне обладнання та інше фармацевтичне право. Цю галузь, яка відноситься до публічного права, часто також називають правом охорони здоров’я.
Корпоративне управління підприємствами: кодекси найвдаліших практик
Authors: Kryshtal  H. O.
Published: October 2022

У статті розкрито зміст поняття «корпоративне управління». Сформульовано кодекси найвдаліших практик та виявлено проблеми управління підприємницькими структурами. Проаналізовано та зазначено перспективи розвитку корпоративного управління та можливості застосування розглянутих кодексів найвдаліших практик на підприємствах України. Автором розглянуті різні види кодексів найкращої практики корпоративного управління; середовище кодексів найкращої практики корпоративного управління; статус кодексів найкращої практики корпоративного управління та механізми стимулювання, що заохочують дотримання кодексів корпоративного управління.
Мета статті: дослідження кодексів найвдаліших практик корпоративного управління в підприємницьких структурах, виділення проблем та перспектив розвитку в Україні.
Наукова новизна роботи полягає в аналізі теоретичних аспектів корпоративного управління та перспектив розвитку кодексів найвдаліших практик підприємствами України.
Методологія. Теоретична та методологічна база дослідження представлена науковими працями провідних учених у галузі корпоративного управління, а також авторським трактуванням впливу корпоративного управління на економічний розвиток та зростання держави. У процесі дослідження використовувалися такі методи, як аналіз та синтез, метод історичного та логічного моделювання. Як теоретичні методи в роботі застосовуються метод формалізації, метод «від абстрактного до конкретного», а також історичний метод, метод економічної інтерпретації. З практичної точки зору в дослідженні також були задіяні метод угруповання статистичних даних, статистичний та економетричний аналіз.
Висновки. У статті проаналізовано теоретичні аспекти перспектив розвитку найвдаліших практик кодексів корпоративного управління підприємствами України. Запропоновано розробку принципів корпоративного управління України розглядати у контексті загального розвитку законодавчої бази у корпоративному секторі. З'ясовано, що Україна увійшла у нове тисячоліття, маючи корпоративне законодавство, нездатне дати тверду основу акціонерних компаній. Доведено, що прийняття Принципів корпоративного управління України виконало подвійну місію: сформувати (національні) принципи на основі міжнародної найкращої практики корпоративного управління та заповнити пробіли в правовому просторі регулювання підприємств, надаючи їм допомогу у впровадженні положень найкращої практики у їх внутрішні документи
«КУЛЬТУРНО‐ВОСПИТАТЕЛЬНАЯ ФУНКЦИЯ ГОСУДАРСТВА»: ЭВОЛЮЦИЯ СМЫСЛА
Authors: Бредихин Алексей Леонидович
Published: October 2022

В статье анализируются понятие, значение и эволюция термина «культурно‐воспитательная функция государства». Обращается внимание на то, что он появился в советской юриспруденции в трудах ученых‐правоведов – родоначальников теории функций Советского государства. Автор выражает мысль, что культурно‐воспитательная функция изначально включала в себя и идеологическую функцию. В настоящее время идеологическая функция получила самостоятельное значение, а культурно‐воспитательная функция приобрела несколько иной смысл.
АКТУАЛЬНЫЕ ВОПРОСЫ ВЗАИМОДЕЙСТВИЯ ОРГАНОВ ПУБЛИЧНОЙ ВЛАСТИ В ФИНАНСОВОЙ СФЕРЕ
Authors: Бойко Наталья Николаевна
Published: October 2022

В статье рассматриваются актуальные вопросы взаимодействия органов государственной власти и органов местного самоуправления в финансовой сфере. Обосновывается, что взаимодействие различных уровней власти происходит на основе взаимовыгодного сотрудничества в интересах граждан Российской Федерации.
ПРИМИРЕНИЕ СТОРОН ПО УГОЛОВНОМУ ДЕЛУ В ДОРЕВОЛЮЦИОННЫЙ ПЕРИОД ИСТОРИИ РОССИИ
Authors: Исаев Флюр Рифович
Published: October 2022

Примирение сторон является институтом уголовного процесса. В статье рассмотрены исторические предпосылки его возникновения, становления и развития от момента создания Древнерусского государства и до Октябрьской революции 1917 г. для понимания сущности и особенностей данного основания для прекращения уголовного дела.
Factibilidad de una empresa comercializadora de artículos ortopédicos en la provincia de Cañar- Ecuador
Authors: Parra Quizhpi Luis Marcos , Ormaza Andrade Jorge Edwin
Published: October 2022

La presente investigación se centra en analizar la conveniencia de implementar una casa comercializadora de artículos ortopédicos en la provincia de Cañar y la aceptación que tendría la misma. Con relación a su orientación metodológica su diseño fue exploratorio y descriptivo, a su vez transversal, no experimental, no probabilístico y con un enfoque cuantitativo, además se basó en la revisión sistemática de la literatura haciendo uso de las bases de datos científicas. Para la recopilación de datos se aplicó la técnica la encuesta y como instrumento el cuestionario, a una muestra de la Población Económicamente Activa (PEA) de Cañar, mediante el cual se observó que la empresa comercializadora de artículos ortopédicos es viable teniendo mayor aceptación en la ciudad de Azogues.  Así también se propone el método de reconocer, oportunidad, tecnología, alianza y verificar (ROTAV) que aporta con fases a considerar en una idea de negocio, ofreciendo pautas a los empresarios o emprendedores mismo que ayudarán a potenciar el bien o servicio.
Az auditorium mint analóg hangszer : Az Opera felújításának építészeti kihívásai
Authors: Wettstein Domonkos
Published: October 2022

"The building is an analog instrument" - which can be interpreted not only in terms of acoustics, but also in connection of relationships between historical and contemporary layers. This instrument can be prepared during the restoration process but awaits fine tuning once performances return to the stage. In whole the main auditorium has been restored to its original form, yet innovative use of electrical and mechanical services has been applied to enhance the spectator's experiences. Not only has the auditorium been fine-tuned, but the same dedication also been applied to restoring this instrument throughout.
Budapesti műemléki lakóépületek rekonstrukciója : Andrássy út 92–94. palotaépület tetőtér-beépítése
Authors: Szecskő Heléna
Published: October 2022

Downtown Budapest residential properties from the turn of the 19th and 20th centuries, organized around inner courtyards, where historicism and free style are mixed with premodernism, socialist modernism and contemporary buildings. The older buildings are typically neglected, in need of renovation, especially the more palatial examples. The damaged roof on this building has been restored to its former splendour using contemporary construction methods, and a new "guest" floor slab, steel roof framing and improved living standards. Even still some of the more traditional elements, such as the timber framed towers, have been restored using traditional skills.
Analisis Pengaruh Pendidikan Kewirausahaan dan Efikasi Diri Sebagai Motivasi Berwirausaha pada Mahasiswa Pendidikan Ekonomi Universitas Negeri Surabaya
Authors: Rahayu Melliana Putri , Kurniawan Riza Yonisa
Published: October 2022

This study aims to analyze the effect of entrepreneurship education and self-efficacy as entrepreneurial motivation for students of Economics education at the State University of Surabaya. The research method was a quantitative causal design. The sample of this research was the students of the Economic Education study program, State University of Surabaya, batch 2020, totaling 66 people who have received the Entrepreneurship Education Course. The research instrument used was a questionnaire. The data analysis technique of this research was multiple regression analysis. The results of this study showed that entrepreneurship education had a positive and significant influence on entrepreneurial motivation. Self-efficacy had a positive and significant impact on entrepreneurial motivation in students, and entrepreneurship education and self-efficacy had a simultaneous effect on the entrepreneurial basis in Economics education students, State University of Surabaya.
Efektivitas Konseling Rasional Emotive Behavior Therapy (REBT) Untuk Meningkatkan Kesehatan Mental Mahasiswa
Authors: Apriyanto Tomy Dwi , Fanisa Nurul , Dwi Rahayu Endang
Published: October 2022

This study aims to analyze the effectiveness of rational emotive behavior therapy (REBT) counseling to improve the mental health of students of the BK Uhamka study program in 2021. The method used in this study was a quasi-experimental one group pretest-posttest design. The approach used in this research is a quantitative approach. The number of samples in this study amounted to 11 students of UHAMKA counseling guidance in 2021 with sampling using the purposive sampling method. This research instrument uses a questionnaire. As for the data analysis technique using the Wilcoxon T test. The results of this study indicate that the Wilcoxon T test with calculations using SPSS ver. 26 prove simp. Sig. (2-tailed) = 0.003. Because the value is 0.003 <0.05, so Ho is rejected, in other words there is a significant effect before and after giving the pretest-posttest. So it can be concluded that group counseling services using REBT techniques are effective in improving students' mental health. It can be seen from the 11 students who took counseling with the REBT technique that their pretest and posttest scores increased or in other words experienced changes after being given counseling services with the REBT technique.
The Different Dimensions of Quality Care Management
Authors: Ribeiro Marlene Morais
Published: October 2022

Health service organizations expect Manager Nurses to develop activities that foster the best quality results both in terms of assistance and in terms of management. To do so, managers have to master management skills in order to understand the activity carried out by the Manager Nurses in an archipelago with several islands. This is a descriptive, analytical and exploratory study of quantitative nature. The data collection instrument was an autofill questionnaire, which included a Perception Scale of the Work of the Manager Nurses. The academic qualifications of the nursing managers are as follows: postgraduate studies in specific areas other than management (15,9%); postgraduate studies in the field of management (36,5%) and master’s degree in different areas (17,5%). The results in the field of the skills of management of nursing care may be the ones that require a bigger investment in terms of training. Regarding the skills in the field of political intervention and advice, the results observed were below expectations. The need for specific training in the field of management is obvious; we were able to prove that most of the Manager Nurses do not have specific training in the field of management, which would allow them to perform the management tasks based on solid knowledge, thus improving the quality of their service.
Adherence of Hypertensive Clients: A Concept Analysis
Authors: Berek Pius A.L , Siswanto Bambang Budi , Irawati Dewi , Jatmiko Wisnu , S. Orte Christian Jay , Aggari Michael I
Published: October 2022

Objective: The purpose of this study is to clarify the concept of adherence of hypertensive clients. Method: Concept analysis proposed by Walker and Avant was applied and searching strategies were done from ProQuest, CINAHL, Scopus and Google Scholar published from 1999 to 2021. Attributes and cases (model, borderline, and contradiction) were identified to clarify the concept. Results: The results of this concept analysis show that adherence to self-care is a complex concept. This involves physical, psychological, social, cultural, and other aspects that are closely related to human resources, both internal and external for each individual. However, the terminology of adherence is closely related to the self-care of hypertensive patients. Conclusion: The study clarified self-care adherence and offered defining attributes; adherence recommendations, perceived benefits and benefits of adherence, realization, and acceptance of current conditions, and ability to perform optimal self-care. Case, borderline, and contradiction models are provided to explain this concept. Antecedents, consequences, and empirical references have also been described. Topics related to self-care adherence must be further explored to advance the nursing practice in managing the hypertensive client.
Sleep Quality of Online Doctor of Nursing Practice Students
Authors: Llaguno John Soliven
Published: October 2022

Sleep problems are common among university students and approximately one third of the general population; however, little is known about the sleep quality of online Doctor of Nursing (DNP) students, and whether the flexible schedule offered by online programs helps support students to adopt a healthy sleep pattern. Guided by the Orem’s theory of self care and deficit, underpinned by DNP essentials, this DNP project examined the sleep quality of online DNP students before and after starting doctoral studies and the factors that influence their sleep quality. Two surveys: 1). Cross-sectional survey, and 2). Pittsburgh Sleep Quality Index (PSQI) were used to collect data from Aspen University – DNP online students. Results suggest that the sleep quality of online DNP students is impacted by their studies. These findings suggest that online DNP students are not immune to the sleep problems that commonly plague brick and mortar university students. There may be a correlation between online studies and sleep quality, but further studies are needed to confirm this relationship. Application of this project and its findings is useful to the nursing profession and to other online programs. An effort may be to institute a health promotion strategy to assess the sleep quality of new incoming online students, followed by re-assessment at interval(s) throughout the programs. This health promotion strategy may provide the online student insight to their sleep quality that may lead to self- care intervention.
The Effect of Improved Nursing Education on 30-day Readmissions in Sickle Cell Patients
Authors: Adedoyin Grace , Nethers Zachary , Mularz Laura
Published: October 2022

Patients with sickle cell disease [1] have episodes of crisis that manifest as severe episodic experiences leading to multiple hospitalizations and recurrent readmissions for acute attacks and routine care [2]. In-hospital mortality is higher for patients who are readmitted versus those who are not. The estimated cost of care annually for the 100,000 patients with SCD in the United States exceeds $1.1 billion just from hospitalizations [3]. Readmissions affect the cost of healthcare in the US, and according to the Agency for Healthcare Research and Quality [4], readmission costs are higher than initial admissions. This project aimed to increase nurses’ knowledge in the care of sickle cell patients at a facility in Central New Jersey and decrease the readmission of patients with sickle cell, leading to better care outcomes.
The Syriac Orphanage and School in Beirut: Building an Elite Transnational Syriac Identity
Authors: Hager Anna
Published: October 2022

Despite a growing interest in Middle Eastern Christianity, an imbalance persists in scholarly understanding of individual Christian communities. The Syriac Orthodox – a non-Catholic Oriental Orthodox community – are one such understudied group. After experiencing massacres during World War I, they resettled in Lebanon, Syria, Iraq and Palestine, which were then newly established nation-states. This article is concerned with the Syriac school in Beirut (also called the Assyrian Orphanage and School) as a case study of the Syriac Orthodox effort to both revive the community and produce an elite that would succeed in a largely non-Syriac, Arabic environment. The school was first founded in 1919 in Adana, Cilicia, in today’s south-eastern Turkey, which was then under French occupation. In 1923 it resettled in Beirut. For several decades it was one of the few, if not the only, successful Syriac Orthodox school in the Middle East. But from the outset it faced an inherent contradiction: despite its focus on the Syriac language, its success was dependent on the graduates’ ability to thrive in a largely non-Syriac, Arab, and in our case, Lebanese, environment. I argue that it was precisely this exclusively defined Syriac identity which enabled their entry into the larger, transnational environment in which national identities were still being negotiated. This article, which is part of a project on the Syriac Orthodox in Lebanon, draws on sources in Arabic, French, English and Syriac from both inside and outside the community (such as the French archives). 1
Reforming the International Monetary System
Authors: Rahman Abdurrahman Arum
Published: October 2022

We proposed a blueprint reform of a shared and science-based international monetary system managed by all (member) countries in the world democratically and decentralized called an “organic system”. The organic system issues a cross-border payment instrument called “organic currency”. The organic currency is only for international transactions between member countries. Domestic transactions continue to use their respective national currencies. Non-member countries cannot use the organic currency. Organic and national currencies are interconvertible to each other through an auto-balancing exchange rate, which follows the economic fundamentals of each country. The organic system provides international liquidity to all member countries free of charge and sustainably, aligns macro-fundamentals, eliminates global imbalances, eliminates the potential of currency crisis, and makes the international monetary system more equitable, balanced, and stable. The organic system can start anywhere in the world and any country may join without the need for comprehensive economic integration.
Antibiotic spectrum of characterized Lactic Acid Bacteria obtained fromdomestic Dahi samples
Authors: B Ramachandra , R Prabha , H Manjunatha
Published: October 2022

From forty lactic acid bacterial isolates obtained from fifteen domestic dahi samples of dahi, thirteen were found to possess probiotic characteristics such as acid and bile tolerance . These acid and bile tolerant lactobacilli isolates further, were identified phenotypically and genotypically as Lb.rhamnosus (5 Nos). Lb. fermentum (3 Nos), Lb. plantarum (3 Nos) and Lb. delbrueckii ssp. bulgaricus (2 Nos). The identified cultures were subjected for the antibiotic test using the disc diffusion technique against Penicillin (10µg), Gentamycin (10µg), Streptomycin (10µg), Chloramphinicol (10µg), Kanamycin (30µg) Erythtomycin (15µg) and Bacitracin (10 µg). All the five strains of Lb.rhamnosus strains were susceptible to all the seven antibiotics tested as they showed more than 10 mm diameter inhibitory zone. Similarly all the three strains of Lb.plantarum, Lb.fermentum and Lb.delbruckii ssp. bulgaricus were susceptible to all the antibiotics to varying degrees. In this study the results clearly demonstrate the susceptible nature of the probiotic Lactobacilli isolates against the commonly used antibiotics.
Quality assessment of milk in supply chain of Parbhani sub-division
Authors: Jawale Manisha , Chappalwar Anita , Devangare Ashok
Published: October 2022

Present study was aimed to detect common adulterants and physico-chemical properties of milk samples collected from different levels viz. farmer/vendors, collection centre (CC) and milk processing plants (Govt./Co-operative dairy) in Parbhani sub-division (Parbhani, Gangakhed, Jintur, Selu, Purna and Palam taluka). During the study minimum and maximum values for water, total solids (TS), fat, solid not fat (SNF), protein and lactose content 79.05%, 10.90% .3.43%, 5.36%, 2.57%, 3.47% 88.88%,12.15%, 11.18%, 9.17%, 4.01%, 5.36% were observed for in the milk samples of Parbhani sub division. Statistical analysis revealed significant difference (P<0.05) in water, fat, protein content, % acidity of milk samples collected from different levels and non significant difference in TS, SNF, lactose content, pH value of milk samples collected from different levels of Parbhani subdivision. However density of milk samples did not differed significantly among both different levels as well as taluka. Most of the compositional parameters were found below the FSSAI standards for buffalo milk. More or less amount of extraneous water was added in all the milk samples of Parbhani subdivision. Adulterants viz, detergents, skim milk powder (SMP), sucrose, nitrate and urea was detected in vendor™s milk samples. None of the adulterant was detected in dairy of Parbhani subdivision; however CC milk samples of Jintur and Purna taluka were only positive for presence of detergent. From the study, it is concluded that adulteration of milk is a generally practiced by vendors which results in the deterioration of nutritive and microbiological quality of milk.
Does livestock help in compensating land inequalities in rural India: Evidencesfrom agricultural census?
Authors: Kaur Manpreet , Singla Naresh
Published: October 2022

Using data of various rounds of Agricultural Census, the study has revealed that rural inequalities are largely attributed to disparities in ownership of land leading to unequal distribution of income. Land inequalities during various rounds among various farmer categories have remained almost constant with minor fluctuations, whereas inequalities in ownership of various livestock such as cattle, buffalo, horse and pony have reduced drastically. The extent of land inequalties is also found to be much larger than livestock inequalties. Small size of operated area among marginal and small cultivators is compensated by ownership of cattle and buffalo, which helps to mitigate inequalities caused by land. The study concludes that government policies should be targeted at strengthening sustained development of livestock activities, which can go a long way in mitigating land inequalities and removing agrarian distress.
The emerging role of radical chemistry in the amination transformation of highly strained [1.1.1]propellane: Bicyclo[1.1.1]pentylamine as bioisosteres of anilines
Authors: Pang Qiwen , Li Yang , Xie Xin , Tang Jie , Liu Qian , Peng Cheng , Li Xiang , Han Bo
Published: October 2022

Bicyclo[1.1.1]pentylamines (BPCAs), emerging as sp3-rich surrogates for aniline and its derivatives, demonstrate unique structural features and physicochemical profiles in medicinal and synthetic chemistry. In recent years, compared with conventional synthetic approaches, the rapid development of radical chemistry enables the assembly of valuable bicyclo[1.1.1]pentylamines scaffold directly through the amination transformation of highly strained [1.1.1]propellane. In this review, we concisely summarize the emerging role of radical chemistry in the construction of BCPAs motif, highlighting two different and powerful radical-involved strategies including C-centered and N-centered radical pathways under appropriate conditions. The future direction concerning BCPAs is also discussed at the end of this review, which aims to provide some inspiration for the research of this promising project.
A novel STAT1 loss-of-function mutation associated with Mendelian susceptibility to mycobacterial disease
Authors: Ye Fanghua , Zhang Wen , Dong Jiajia , Peng Min , Fan Chenying , Deng Wenjun , Zhang Hui , Yang Liangchun
Published: October 2022

Mendelian susceptibility to mycobacterial diseases (MSMD) is a rare congenital immune deficiency characterized by susceptibility to weakly virulent mycobacteria. Loss-of-function (LOF) mutation of signal transducer and activator of transcription 1 (STAT1) is one of the common genetic causes of MSMD. In this study, we identified a patient who presented with multiple lymph node enlargements and multiple osteolytic disruptions. Mycobacterium gordonae infection was confirmed by metagenomic next-generation sequencing. Whole-exome sequencing identified a novel paternal heterozygous mutation in exon 22 of STAT1 (NM_007315.4, c.1892T>C, p.Val631Ala). This variant was confirmed pathogenic by multiple software predictions. Based on functional assays, STAT1 expression in STAT1V631A cells was not different from STAT1WT cells. But STAT1V631A mutation caused much lower activation of STAT1 when stimulated by interferon-γ (IFN-γ). Fluorescence localization analysis revealed that both STAT1V631A and STAT1WT proteins were located in the cytoplasm, and only a few STAT1V631A proteins were translocated to the nucleus in response to IFN-γ. These results suggest that STAT1V631A leads to LOF in IFN-γ-mediated mycobacterial immunity, resulting in MSMD. Treatment with antibiotics has achieved ideal disease control for this patient, and no adverse events occurred during follow-up. The STAT1 LOF deficiency is a genetic cause of MSMD, which should be considered in patients with mycobacterial disease, especially those with bone involvement.
Effects of fences and fence gaps on the movement behavior of three southern African antelope species
Authors: Hering Robert , Hauptfleisch Morgan , Kramer-Schadt Stephanie , Stiegler Jonas , Blaum Niels
Published: October 2022

Globally, migratory ungulates are affected by fences. While field observational studies reveal the amount of animal–fence interactions across taxa, GPS tracking-based studies uncover fence effects on movement patterns and habitat selection. However, studies on the direct effects of fences and fence gaps on movement behavior, especially based on high-frequency tracking data, are scarce. We used GPS tracking on three common African antelopes (Tragelaphus strepsiceros, Antidorcas marsupialis, and T. oryx) with movement strategies ranging from range residency to nomadism in a semi-arid, Namibian savanna traversed by wildlife-proof fences that elephants have regularly breached. We classified major forms of ungulate–fence interaction types on a seasonal and a daily scale. Furthermore, we recorded the distances and times spent at fences regarding the total individual space use. Based on this, we analyzed the direct effects of fences and fence gaps on the animals’ movement behavior for the previously defined types of animal–fence interactions. Antelope-fence interactions peaked during the early hours of the day and during seasonal transitions when the limiting resource changed between water and forage. Major types of ungulate–fence interactions were quick, trace-like, or marked by halts. We found that the amount of time spent at fences was highest for nomadic eland. Migratory springbok adjusted their space use concerning fence gap positions. If the small home ranges of sedentary kudu included a fence, they frequently interacted with this fence. For springbok and eland, distance traveled along a fence declined with increasing utilization of a fence gap. All species reduced their speed in the proximity of a fence but often increased their speed when encountering the fence. Crossing a fence led to increased speeds for all species. We demonstrate that fence effects mainly occur during crucial foraging times (seasonal scale) and during times of directed movements (daily scale). Importantly, we provide evidence that fences directly alter antelope movement behaviors with negative implications for energy budgets and that persistent fence gaps can reduce the intensity of such alterations. Our findings help to guide future animal–fence studies and provide insights for wildlife fencing and fence gap planning.
Shexiang Baoxin Pill (MUSKARDIA) reduces major adverse cardiovascular events in women with stable coronary artery disease: A subgroup analysis of a phase IV randomized clinical trial
Authors: Shi Haiming , Zhou Jingmin , Ma Changsheng , Ji Fusui , Wu Yang , Zhao Yulan , Qian Jun , Wang Xiaolong
Published: October 2022

Background

A previous phase IV trial revealed sex as a potential effect modifier of MUSKARDIA efficacy in stable coronary artery disease (CAD).

Objective

To assess the clinical effect of MUSKARDIA as a supplemental treatment to optimal medical therapy (OMT) in stable CAD cases.

Methods

This study was a subgroup analysis of a multicenter, randomized, double-blinded, placebo-controlled phase IV clinical study. Eligible individuals underwent randomization to the oral MUSKARDIA and placebo groups and were treated for 24 months. All participants received OMT according to existing guidelines. The primary composite outcome was the major adverse cardiovascular event (MACE), included cardiovascular death, non-fatal myocardial infarction (MI), or non-fatal stroke. The secondary composite outcome encompassed all-cause mortality, non-fatal MI, non-fatal stroke, hospitalization for unstable angina and/or heart failure, and undergoing coronary procedure/surgery during treatment. Safety signals, especially cardiovascular adverse events (AEs), were analyzed.

Results

The female subgroup included 776 participants (384 and 392 in the MUSKARDIA and placebo groups, respectively). The occurrence of the primary composite outcome was lower in the MUSKARDIA group compared with placebo-treated individuals (HR = 0.27, 95%CI: 0.09–0.83; P = 0.02), but the secondary composite outcome showed no significant difference (HR = 0.77, 95%CI: 0.47–1.25; P = 0.29). The MUSKARDIA group had reduced incidence of cardiovascular AEs compared with placebo-treated cases (2.9% vs. 5.6%).

Conclusion

As a supplemental treatment to OMT, 24-month administration of MUSKARDIA is effective and safe in female stable CAD cases.

Clinical trial registration

[https://clinicaltrials.gov/], identifier [NCT01897805].
The RNA-seq based endometrial receptivity test (rsERT) compared to pinopode: A better diagnostic tool for endometrial receptivity for patients with recurrent implantation failure in Chinese population
Authors: Chen Jingjing , He Aihua , Zhang Qiong , Zhao Jing , Fu Jing , Li Hui , Li Yanping
Published: October 2022

Displaced window of implantation (WOI) is one of the endometrial origins that accounts for implantation failure, especially for patients with recurrent implantation failure (RIF), yet no standard diagnostic tool has been recognized. The study consists of two parts, aiming to compare the concordance and efficacy of the diagnostic tools, the newly developed RNA-seq based endometrial receptivity test (rsERT) to the conventional pinopode, in diagnosing WOI and guiding personalized embryo transfer (pET). With the same group of RIF patients, the rsERT diagnosed 32 patients (65.31%) with normal WOIs, and most of the displacements were advancements (30.61%). While according to pinopode, only 14 patients (28.57%) were found with normal WOIs, and most patients (63.27%) presented delayed growth patterns. After conducting pET, patients in the rsERT group had higher successful pregnancy rates while requiring fewer ET cycles (50.00% vs. 16.67%, p=0.001). The study proved poor consistency between the diagnostic tools of endometrial receptivity based on cellular structure and gene profiling, and it supported rsERT as a reliable tool with potential clinical value.
Triple drug therapy with GABA, sitagliptin, and omeprazole prevents type 1 diabetes onset and promotes its reversal in non-obese diabetic mice
Authors: Lagunas-Rangel Francisco Alejandro , Koshelev Daniil , Nedorubov Andrej , Kosheleva Liudmila , Trukhan Vladimir , Rabinovitch Alexander , Schiöth Helgi B. , Levit Shmuel
Published: October 2022

Previous studies have reported that dual drug combinations consisting of γ-aminobutyric acid (GABA) together with a dipeptidyl-peptidase-4 inhibitor (DPP-4i), also a DPP-4i with a proton pump inhibitor (PPI), could improve pancreatic β-cell function and ameliorate diabetes in diabetic mice. In this study, we sought to determine if a triple drug combination of GABA, a DPP-4i and a PPI might have superior therapeutic effects compared with double drug therapies in the prevention and reversal of diabetes in the non-obese diabetic (NOD) mouse model of human type 1 diabetes (T1D). In a diabetes prevention arm of the study, the triple drug combination of GABA, a DPP-4i, and a PPI exhibited superior therapeutic effects in preventing the onset of diabetes compared with all the double drug combinations and placebo. Also, the triple drug combination significantly increased circulating C-peptide and serum insulin levels in the mice. In a diabetes reversal arm of the study, the triple drug combination was superior to all of the double drug combinations in reducing hyperglycemia in the mice. In addition, the triple drug combination was the most effective in increasing circulating levels of C-peptide and serum insulin, thereby significantly reducing exogenous insulin needs. The combination of GABA, a DPP-4i and a PPI appears to be a promising and easily scalable therapy for the treatment and prevention of T1D.