bluuebunny/crossref_metadata_2025 huggingface dataset:
Perancangan Rangkaian Arus AC dan DC Listrik Menggunakan Simulink Matlab
Authors: Jannah Annur Miftahul , Yolanda Valina , Nasir Muhammad
Published: March 2023

Penelitian ini bertujuan untuk memuat kajian mengenai perancangan arus AC dan DC dengan memanfaatkan simulink matlab. Penelitian ini menggunakan pengembangan 4D yang dilaksanakan hanya sampai tahap perancangan dan pengembangan. Hasil penelitian untuk arus AC menunjukkan sinyal keluaran berbentuk gelombang sinus, sedangkan hasil penelitian pada arus DC menghasilkan sinyal keluaran yang lurus dengan tegangan yang tetap. Sehingga hasil yang diperoleh disesuaikan dengan konsep simulink matlab dalam perancangan rangkaian arus AC dan DC listrik yang telah diajarkan di sekolah. Implikasi dari penelitian ini adalah simulink ini dapat digunakan sebagai salah satu penunjang praktikum fisika dari segi visualisasi. This study aims to include a study on the design of AC and DC currents using Matlab Simulink. This research uses 4D development, which is carried out only until the design and development stage. The research results for AC current show that the output signal is in the form of a sine wave, while the research on DC current produces a straight output signal with a fixed voltage. So that the results obtained are adjusted to the concepts that have been taught at school. This research implies that this Simulink can be used as a support for physics practicum in terms of visualization.
Profil Aspek Interpretasi Pemahaman Konsep Materi Kinematika Gerak Lurus pada Siswa SMAN 6 Kota Bengkulu
Authors: Apridonata Wahyu , Syarkowi Ahmad , Purwanto Andik
Published: March 2023

Penelitian ini bertujuan untuk menganalisis gambaran mengenai pemahaman konsep pada materi kinematika gerak lurus pada aspek interpretasi. Metode penelitian yang digunakan yakni menggunakan metode cross sectional. Sampel pada penelitian ini yakni siswa SMAN 6 Kota Bengkulu sebanyak 70 responden. Berdasarkan hasil yang diperoleh siswa SMAN 6 Kota Bengkulu dikategorikan sedang dalam menjawab soal pemahaman konsep aspek interpretasi khususnya pada materi kinematika gerak lurus dengan persentase rata-rata skornya 35,12%. Instrumen yang digunakan berupa soal pretest pilihan ganda dimana satu soal memiliki lima pilihan jawaban. Berdasarkan hasil test responden terdapat indikator yang ketiga yaitu menjelaskan ciri-ciri gerak jatuh bebas memiliki persentase tertinggi sebesar 45% dan indikator pertama yakni menjelaskan perbedaan gerak lurus dengan kecepatan konstan dan gerak lurus dengan percepatan konstan  memiliki persentase terendah sebesar 30%. Sehingga pemahaman konsep pada siswa SMAN 6 Kota Bengkulu masih dikategorikan sedang. This study aims to analyze the understanding of straight motion kinematics in interpretation. The research method used is a cross-sectional method. This study's sample was SMAN 6 Bengkulu City students, with as many as 70 respondents. Based on the results obtained by students of SMAN 6 Bengkulu City, they are categorized as moderate in answering questions about understanding the concept of interpretation aspects, especially in straight-motion kinematics material, with an average percentage score of 35.12%. The instrument used is in the form of multiple choice pretest questions where one question has five answer choices. Based on the results of the respondent's test, there is a third indicator, namely explaining the characteristics of free fall motion, which has the highest percentage of 45% and the first indicator, which explains the difference between straight motion with constant speed and straight motion with constant acceleration, has the lowest percentage of 30%. So that the understanding of the concept in SMAN 6 Bengkulu City students is still categorized as moderate.
Pengembangan Instrumen Tes Keterampilan Problem Solving pada Materi Gerak Lurus di SMA
Authors: Patimah Siti , Putri Desy Hanisa , Syarkowi Ahmad
Published: March 2023

Penelitian ini bertujuan untuk menghasilkan instrument tes keterampilan problem solving yang valid dan mengetahui kelayakan instrumen tes keterampilan problem solving pada materi gerak lurus. Penelitian ini menggunkan model (Research andDevelopment). Dalam penelitian ini menggunakan model 4D denganlangkah-langkahDefine,Design,Develop dan Dissemination. Namun untuk penelitian ini dibatasi sampai tahap 3D yaitu Define,Design, dan Develop. Tahapan analisis pada Define dilakukan dengan penyebaran angket kebutuhan yang dilakukan di tiga sekolah yaitu SMA N 7 Kota Bengkulu, SMA N 4 Kota Bengkulu, dan SMA N 9 Kota Bengkulu kemudian dilakukan perancangan pengembangan instrument soal. Instrumen tes berisikan 6 soal uraian yang menggunakan indikator keterampilan problem solving. Setelah itu instrument yang telah disusun divalidasi oleh tiga pakar yaitu dua ahli dan satu praktisi. Berdasarkanhasilujivalidasiaspekmateri, aspek konstruksi, aspek bahasa memperoleh persentase validasi berturut-turut sebesar 100%, 98,6% dan 100%. Dengan demikian instrumen yang disusun dikategorikansangat layak digunakan. This study aims to produce a valid problem-solving skill test instrument and determine the feasibility of a problem-solving skill test instrument on straight-motion material.This research uses a model (Research and Development). The development model used is a 4D model with the steps of Define, Design, Develop and Dissemination. However, this research is limited to the 3D stage, namely Define, Design, and Develop. The analysis stage in Define was carried out by distributing a needs questionnaire which was carried out in three schools, namely SMA N 7 Bengkulu City, SMA N 4 Bengkulu City, and SMA N 9 Bengkulu City; then carried out the design of the question instrument development. The test instrument contains six description questions that use problem-solving. After that, the instrument that has been compiled is validated by three experts, namely two experts and one practitioner. Based on the validation test results, the material aspect, construction aspect, and language aspect obtained validation percentages of 100%, 98.6% and 100%, respectively. Thus, the instruments compiled are categorized as very suitable for use.
The Effect of STEAM Learning on Improving Each Indicator of Students' Creative Thinking in Physics Learning
Authors: Witdiya Tasta , Supriadi Gito , Supriatin Atin , Annovasho Jhelang
Published: March 2023

The research aims to analyze the effectiveness toward which STEAM learning improves each indication of students' creative thinking ability in physics learning. This research used a quantitative approach with a quasi-experimental design and a non-equivalent pretest-posttest control group design. In this research, the Class XI science students of SMA Negeri 1 Mentaya Hilir Utara during the 2022-2023 school year would present as the population. Class XI IPA I was selected as the experimental class, while class XI IPA II was presented as the control class in the sample. The collected research data will be analyzed using the Willcoxon test, the Mann-Whitney difference test, and the N-gain test. The improvement (N-Gain) of all indicators has reached the moderate category. Indications in the element of elaboration increased the highest, while indicators in the aspect of originality increased the lowest. Based on the improvement in each indicator and the results of regression tests on each indicator, it is demonstrated that STEAM learning has a very favorable effect on students' creative thinking abilities. STEAM-based learning is recommended for usage as an innovation in physics learning in schools in order to develop creative thinking.
Plantation de haies nectarifères pour les pollinisateurs : des agriculteurs accompagnés par le Parc national des Cévennes
Authors: SAVARY Camille
Published: March 2023

L’une des orientations de la charte du Parc national des Cévennes est de promouvoir une agriculture respectueuse de la biodiversité et des principes de l’agroécologie. Dans un contexte d’évolution globale du climat et de raréfaction de la ressource nectarifère, le Parc a lancé de 2020 à 2023 un programme d'envergure afin d’être un territoire pilote pour l’accueil des pollinisateurs sauvages et domestiques.
Renal Denervation Helps Preserve the Ejection Fraction by Pre-Serving Endocardial-Endothelial Function During Heart Failure
Authors: Pushpakumar Sathnur , Singh Mahavir , Zheng Yuting , Akinterinwa Oluwaseun E. , Mokshagundam Sri Prakash L. , Sen Utpal , Kalra Dinesh K. , Tyagi Suresh C.
Published: March 2023

Although renal denervation (RDN) protects against hypertension, hypertrophy, and heart failure (HF), it is not clear whether RDN preserves ejection fraction (EF) during heart failure (HFpEF). To test this hypothesis, we simulated chronic congestive cardiopulmonary heart failure (CHF) by creating aorta-vena cava fistula (AVF) in C57BL/6J wild type (WT) mice. There are four ways to create experimental CHF: (1) myocardial infarction (MI) which is basically ligating coronary by instrumenting and injuring the heart; (2) trans-aortic constriction (TAC), although it mimics systematic hypertension but TAC again constricts aorta on top of the heart and exposes the heart; (3) acquired CHF such as by dietary factors, diabetes/salt diets etc. but it is multifactorial, and finally (4) AVF, which is the only one wherein AVF is created ~1cm below the kidney where the aorta and vena cava share the common middle-wall. By creating fistula, the red blood enters vena cava without an injury to the heart. This model mimics CHF such as during aging where with age the preload keeps increasing than the aging heart can pump out due to the weakened cardiac myocytes. This also involves the right ventricle to lung to left ventricle flow, thus creating congestion. The heart in AVF goes to transition from preserved to reduced EF (i.e., HFpEF to HFrEF). In fact, there are more models of volume overload, such as the pacing-induced and mitral valve regurgitation but these are also injurious models. Our lab is one of the original labs in creating and studying the AVF phenotype. The RDN was created by treating the cleaned bilateral renal artery. After 6 weeks, blood, heart, and renal samples were analyzed for exosome, cardiac regeneration markers and renal cortex proteinases. Cardiac function was analyzed by echocardiogram (ECHO). Fibrosis was analyzed with trichrome staining. The results suggested that there was robust increase in exosomes’ level in AVF blood, suggesting compensatory systemic response during AVF-CHF. During AVF there was no change in cardiac eNOS, Wnt1 and β-catenin, however; during RDN there was robust increase in eNOS, Wnt1 and β-catenin compared to the sham group. As expected in HFpEF there was perivascular fibrosis, hypertrophy and pEF. Interestingly, increased levels of eNOS suggested that despite fibrosis, the NO generation was higher that most likely contributed to pEF during HF. The RDN intervention revealed an increase in renal cortical caspase 8 and a decrease in caspase 9. Since caspase 8 is protective and caspase 9 is apoptotic, we suggest that RDN protects against renal stresses, and apoptosis. Our findings also suggest that RDN is cardioprotective during HFpEF via the preservation of eNOS and accompanied endocardial-endothelial function.
Automatic Generation of SBML Kinetic Models from Natural Language Texts using GPT
Authors: Maeda Kazuhiro , Kurata Hiroyuki
Published: March 2023

Kinetic modeling is an essential tool in systems biology research, enabling the quantitative analysis of biological systems and predicting their behavior. However, the development of kinetic models is a complex and time-consuming process. In this article, we propose a novel approach called KinModGPT, which generates kinetic models directly from natural language text. KinModGPT employs GPT-3 as a natural language interpreter and Tellurium as an SBML generator. We demonstrate the effectiveness of KinModGPT in creating SBML models from complex natural language descriptions of biochemical reactions. KinModGPT successfully generates valid SBML models from a range of natural language model descriptions of metabolic pathways, protein-protein interaction networks, and heat shock response. This article demonstrates the potential of KinModGPT in kinetic modeling automation.
Detection of Toxoplasma gondii in Sylvatic Rodents in Poland Using Molecular and Serological Methods
Authors: Nowicka Joanna , Antolová Daniela , Lass Anna , Biernat Beata , Baranowicz Karolina , Goll Aleksander , Krupińska Martyna , Ferra Bartłomiej , Strachecka Aneta , Behnke Jerzy M. , Bajer Anna , Grzybek Maciej
Published: March 2023

Rodents are known to be reservoirs of Toxoplasma gondii and keep the parasite circulation in the environment. We conducted biomonitoring to assess the role of sylvatic rodents in maintaining T. gondii and to analyse the prevalence and seroprevalence of the parasite in seven wild rodent species. Rodents were collected in our study sites (woodland and open grasslands) located in northeastern Poland and dissected. We collected brain, spleen, blood and serum samples. We applied both molecular (PCR assay, nested-PCR assay) and serological (ELISA and agglutination tests) methods to indicate the best approach for application in the biomonitoring of T. gondii in small mammals. We screened samples from 95 individuals sing PCR assays and found no T. gondii DNA. The agglutination test showed no signal. We found antibodies against T. gondii in 6 sera samples out of 74 analysed (seroprevalence = 8.11% [4.0-17.1]). Our results confirm that rodents participate in the life cycle of T. gondii as reservoirs of this parasite in the sylvatic environment. However, biomonitoring should be performed with the ELISA tests to search for T. gondii antigens, rather than a molecular approach only.
General Consumer Preferences for Sleep-Tracking Wearables: The Role of Expert Validation
Authors: Schwartz Lindsay P , Devine Jaime K , Choynowski Jake , Hursh Steven R
Published: March 2023

The goal of this report was to examine the behavioral economic demand for consumer sleep technologies with different levels of validation and endorsement. The value or importance consumers place in different validation methods and the organizations conducting the evaluations was also assessed. Survey data were collected from 113 participants on Amazon mTurk. Participants indicated their likelihood of purchasing devices that varied in level of validation across a series of increasing prices. Demand curves were analyzed to determine the relative value of each watch type. Participants also reported how valuable or important different aspects of device validation were to them. Devices that were both evaluated against laboratory measures and endorsed by sleep researchers had the most value, followed by those only evaluated against laboratory measures, and then those not evaluated against any laboratory measures. The unit price at which there was 50% probability of purchase was increased by $25 or $44 for evaluation or endorsement, respectively. Respondents indicated the most valuable features were a measure of sleep duration, that it was most important that devices were validated against measures of sleep from a laboratory or hospital, and that they would put a high value on sleep tracker endorsements from a university or academic institution. Consumer demand is greatest for a device that has been evaluated by an independent laboratory for accuracy in measuring sleep and is endorsed by an academic, medical, or government institution. These results indicate a role for scientific evaluation and endorsement in consumer preference for sleep trackers.
Slot opening displacement technique for cogging torque reduction of axial flux brushless DC motor for electric two-wheeler application
Authors: Patel A. N.
Published: March 2023

Introduction. Reduction of cogging torque is the crucial design consideration of axial flux brushless DC (BLDC) motor, particularly for low-speed applications. Aim. The slot opening displacement technique is presented in this article to reduce cogging torque in axial flux BLDC motors suitable for electric two-wheeler applications. Methods. Double rotor single stator configuration of axial flux BLDC motor is the most suitable for such vehicular applications. Initially double rotor single stator 250 W, 150 rpm axial flux BLDC motor is designed with stator slot opening in middle position and considered as reference motor for further analysis. To evaluate the cogging torque profile of the reference motor 3D finite element modeling and analysis are performed. The design is enhanced by dividing all stator teeth into groups and displacing the slot openings of each group in opposite direction with respect to the adjacent group. Results. The influence of slot opening displacement on cogging torque is evaluated with finite element modeling and analysis. As cogging torque is reduced from 1.23 N×m to 0.63 N×m, the slot opening displacement technique is found to be effective in reducing cogging torque of axial flux BLDC motor.
Exploration and mitigation of power quality problems in radial distribution system by placing distributed generation through voltage stability index
Authors: Manohara M. , Veera Reddy V. C. , Vijaya Kumar M.
Published: March 2023

Introduction. Distributed generation has played an important role in many aspects of sustainability, such as improving voltage profiles and reducing power losses, in the distribution network. Problem. Frequent variation of loads causes many complications while placing and sizing of distributed generation in the radial distribution network, via quality of supply, and stability of the system. Goal of the paper is to investigate and mitigate the power quality issues towards stabilizing the system during distributed generations placed in the system under various loading conditions. Methodology. The line voltage stability index analyses and enhances the performance of the radial distribution network by effective sizing and location of distributed generation towards the objective function. Practical value. A standard test system IEEE-69 bus radial distribution network is used to understand through MATLAB environment.
OBJECTIVES AND INFORMATION BASE FOR ANALYZING THE EFFICIENCY OF LABOR RESOURCES UTILIZATION
Authors: Pohorielov Serhiy
Published: March 2023

The development of market relations and related structural changes in the economy have a significant impact on the processes of economic activity. Most enterprises operate in a tough environment of external and internal competition, which requires them to take active steps to optimize and adjust technological processes and economic strategy, both current operations and enterprise development. Optimization and adjustment of current operations is achieved by making appropriate management decisions, which requires a comprehensive analysis of the company's performance. It is used to develop the strategy and tactics of the company's development, to make plans and management decisions, to monitor their implementation, to identify reserves for improving production efficiency, and to evaluate the performance of the company, its divisions and employees.

At the same time, as the practice of Ukrainian enterprises, especially privatized ones, shows, the use of modern methods is too limited, as evidenced by the large number of economically inexpedient business projects at various levels, low levels of labor productivity and profitability, unreasonably high costs of maintaining the administrative apparatus, which ultimately leads to severe financial losses up to the bankruptcy of the enterprise.

Undoubtedly, this situation is shaped by a number of factors, among which the economic instability of the external business environment is the most important. However, internal factors also play a significant role, namely, the low level and quality of enterprise management, one of which is the inability to analyze activities and identify factors affecting both economic activity and the financial position of an enterprise.
ESSENTIAL CHARACTERISTICS OF DIAGRAMMATIC REPRESENTATIONS IN CREATIVE ARCHITECTURAL DESIGN
Authors:   Andrzej Frycz Modrzewski Krakow University, Poland Faculty of Architecture and Fine Arts, Maryńczuk Paweł
Published: March 2023

In this paper I attempt to identify the fundamental properties of the diagram as a form of representation in opposition to purely symbolic representation The author’s intent is to present the characteristics of architectural diagrams as they are and to analyse their role in argumentation, or, more broadly, in various forms of justifying diagrammatic representations. However, these two aspects cannot be fully separated from each other – the distinctive features of diagrams are of course tied with the distinctive properties of cognitive processes associated with them. This discussion will present just how diverse diagrams and types of thinking can be, and the wide range of roles that representations can play in architectural cognitionKey words: design process, diagram features, diagram thinking, cognitive processes, presentation methods, philosophical problems.
PROBLEMS REGARDING THE CONSERVATION, PLANNING AND MANAGEMENT OF THE VANTAGE POINTS OF GREATER POLAND FOLWARKS
Authors:   National Institute of Cultural Heritage, Poland Regional Office in Poznań, Mikulski Daniel
Published: March 2023

The landowners' houses together with the manorial and park layout gave a unique character to the landscape of Wielkopolska. They are characterized by high sensitivity in terms of the landscape capacity of the vantage points. This is because not only the loss of the historical building substance or greenery, but also the new buildings erected in their surroundings, disturb the legibility of the relics of the manorial economy. The problem is the point protection of these elementsfore, which will probably be emphasized soon by the results of the landscape audit. The Italian experience in the protection, planning and management of landscapes, the character of which was given by landowners, brings inspiring conclusions.
Taxonomía integrativa y evolución
Authors: Coordinador Equipo
Published: March 2023

En este simposio se presentaron investigaciones sobre el uso del sonido en el estudio de sistemas biológicos, con énfasis en la delimitación de especies, descripción de vocalizaciones y el papel de los sonidos en la evolución. Se discutieron temas como el uso de vocalizaciones como herramienta para identificar y distinguir diferentes especies, técnicas utilizadas para estudiar la producción, recepción y percepción de vocalizaciones, y los factores ecológicos y evolutivos que influyen en el desarrollo de estos sonidos. El simposio contó con la participación de expertos de varias disciplinas que compartieron sus conocimientos e investigaciones sobre el uso del sonido en el estudio de sistemas biológicos.
Obesity and Asthma Risk in Indonesian Adults: Findings from the 2018 Indonesia Basic Health Research
Authors: Nisa Hoirun
Published: March 2023

Obesity and asthma are both global public health challenges. Mounting evidence suggests that obesity may increase asthma risk in adults; however, the association by sex remains uncertain. This study examined the association of obesity with asthma risk in Indonesian adult men and women. Data were obtained from the 2018 Indonesia Basic Health Research. The analysis included 299,837 men and 333,218 women aged ≥18 years. Asthma was identified by the self-report of a doctor’s diagnosis. Obesity was defined as a body mass index ≥30 kg/m2. A logistic regression was used for data analysis. Asthma prevalence was 2.7% (2.5% in men and 2.8% in women) and was higher in obese than non-obese adults. The adjusted odds ratio (aOR) of having asthma-related obesity was 1.22, 95% Confidence Interval (CI) = 1.17–1.28 (aOR = 1.25, 95% CI = 1.21–1.34 in women and aOR = 1.14, 95% CI = 1.05–1.25 in men). In conclusion, asthma prevalence was relatively low in Indonesian adults and slightly higher in women than men. Both men and women had a slight increase in the odds of having asthma-related obesity. Longitudinal studies are needed to understand better the causality association of obesity with asthma in adults.
Understanding the Health-related Quality of Life of People Living with HIV Based on Sexual Orientation
Authors: Sitorus Rico Januar , Antara Nyoman Yudi , Sangalang Reymart , Panjaitan Merry Natalia , Fauk Nelsensius Klau
Published: March 2023

Human immunodeficiency virus (HIV) infection has detrimental impacts on the lives of different population groups living with HIV, including men who have sex with men (MSM). Using the World Health Organization Quality of Life questionnaire, this study aimed to assess the health-related quality of life of men living with HIV with different sexual orientations and to determine the dominant influential factors. This cross-sectional study involved 206 men living with HIV. They were recruited from the Sriwijaya Plus Foundation and a medical facility that provided antiretroviral therapy. The data were analyzed using Chi-square and binomial logistic regression. The analysis showed that the percentage of MSM patients was greater than that of non-MSM patients, accounting for 68.9% of the total population. The multivariate logistic regression revealed that the most dominant influential factor was depression status (PR = 5.417; 95% CI = 2.473–11.876), with the majority of the depressed patients being 5.417 times more at risk of a lower quality of life compared to others. These findings suggest that depression can lead to a low quality of life among HIV patients.
¡¡Cien años de vida perdularia!!
Authors: Abelardo M. Gamarra
Published: March 2023

Cien años de vida perdularia se publicó en 1921, el año del centenario de la independencia del Perú, y el autor lejos de publicar un libro solemne o acorde al espíritu celebratorio, eligió reunir textos cargados de crítica y temperados con sentido del humor. Hay crítica y denuncia en su obra, ciertamente, pero todo está empacado y adornado con ingenio y picardía. Esta obra del Tunante es de artículos de costumbres, como lo fue Tradiciones peruanas de Ricardo Palma.
Maintaining Structural Integrity for New Well Design
Authors: Khan Danish Ahmed , Acuna Manuel Centeno , Al-Asadi Yousif Baqer , Sebbane Slimane , Tossonian Hoory , Chica Pablo , Hussein Ahmed Mudheher
Published: March 2023

Maintaining the structural integrity of the wellbore and preventing it from collapsing requires maintaining the balance between in-situ stresses and drilling practices. Historically, deviated wells drilled in this super-giant oil field in Iraq (Figure 1 – Iraq Field developments), with an estimated 38 billion barrels of oil in place in multiple reservoirs, were conservative and based on conventional well design. The conventional design approach separated Anhydrite-Marl and Gravel formations from the potential loss circulation zone of the porous vuggy limestone formations. The new well design, called the Slim Design, was to drill through these heterogeneous formations and isolate them across a single production casing with a significant reduction in well delivery time and tubular cost.

Construction of 1D Geomechanics Model is presented that uses data from offset open hole logs, offset well data, and utilizes mohr coulomb and modified lade methods to examine the wellbore stability models. These models were used to define the minimum required mud weight required to drill through heterogenous formations and avoid wellbore instability issues. Drilling strategy through loss zone was optimized based on risk identification from geomechanics – maintain Hydrostatic over Anhydrite-Marl and Gravel formations to prevent it from collapse. Severe to complete losses observed while performing 9-5/8in cement job due to natural fractures in Limestone formations can only be compensated by performing the top job i.e., the volume of cement required to fill the annulus to achieve the acceptance criteria. The cementing strategy was modified based on input from geo-mechanics as 90% of overburden vertical stress was used as a pressure limit to squeeze cement into the annulus. Results obtained from this study were in good agreement with field observations.

Figure 1 IRAQ FIELD DEVELOPMENTS1
High Power Laser Technology Toward the Downhole Applications: The Effect on Permeability
Authors: Alharith Abdullah , Batarseh Sameeh , San Roman Alerigi Damian
Published: March 2023

In response to the high oil and gas demand, new sustainable technologies were developed and evolved to improve the production. Among those new technologies is the high power laser technology. Laser technology attracted the industry due to its unique properties and the potential to revolutionize the oil and gas industry in many applications. Such applications include; drilling, perforation, descaling, pipe cutting, casing-casing annulus remedy, and fracture initiation.

This paper will discuss the effect of high power laser operations on the permeability during the utilization of this method for oil and gas applications. The interaction between the high power laser and the formation induces high thermal energy to the geological structure of the reservoir that will influence the permeability of the formation.

Different types of experimental work examine the consequences of high power laser on permeability. Several research studies are conducted on different rock samples; the samples include carbonate, sandstone, and shale. The high power laser induces thermal energy, which affects the physical structure of the rock sample by altering the physical and chemical properties of the rock. Such changes include decomposition reaction, dehydration, clays collapse, and micro-cracking. Various lab techniques are used for analysis and characterization, including thermogravimetric analyzer (TGA), and permeability measuring machine. The lab work showed improvement in permeability in most rock samples that are treated with high power laser energy. High power laser technology is a friendly environmental method for downhole oil and gas applications. The paper demonstrated that the technology is non-damaging and enhances the flow properties in the well. Improving the production by enhancing the permeability.
Audience Effects in Sooty Mangabey Agonistic Behaviour
Authors: Quintero Fredy , Touitou Sonia , Magris Martina , Zuberbühler Klaus
Published: March 2023

Aggression is a functional term that refers to behaviour in competitive interactions, such as repelling predators, accessing resources or pursuing other self-serving interests. However, aggression also has a secondary function as a partner control mechanism to extort cooperation and tolerance from others. Both functions are mainly available to high-ranking individuals interacting with lower-ranking opponents, which raises the question of how do lower-ranking individuals achieve their goals? One possibility is by predicting future reactions of uninvolved bystanders and adjusting one’s behaviour accordingly. Here, we investigated how free-ranging sooty mangabeys, a socially tolerant forest dwelling primate, used aggression depending on audience composition. As predicted, high-ranking individuals used aggression universally to displace lower-ranking competitors, but we also found several audience effects for other group members. First, aggression of lower-ranking individuals was significantly augmented in front of high-ranking audiences, often accompanied by vocalisations. Second, individuals generally refrained from severe aggression in front of friends and when audience size was small. We discuss these patterns of audience-dependent aggressive behaviour and conclude that, while mangabeys naturally pursue selfish goals, they also adjust levels and rates of aggression depending on who observes them, consistent with the idea of pursuing longer-term goals of securing cooperation and tolerance.
Key factors for teaching and learning - Teachers’ experiences and reflections on literacy teaching
Authors: Tjernberg Catharina Cecilia
Published: March 2023

A group of students were followed in a longitudinal study throughout their compulsory
school years. The data collected formed the starting point for a focusgroup
discussion, the results of which are reported and discussed in this article.
The aim is to investigate the factors that the teachers consider especially important
for the students’ learning processes, and to reflect on what characterises
teaching practices that promote participation and learning. The results show that
the most important factor in a successful teacher’s work is the ability to meet the
students according to their individual needs; this also involves using the student
group as a learning resource, and to adopt a critical attitude to one’s own teaching
with the aim of developing it. Attitude, high expectations and a positive belief in
the students are key factors here, as well as the ability to stage well-balanced
teaching with a focus on content, language, and language use.
The importance of collegial learning for the teacher’s professional development
is emphasised, as is the value of enjoying one’s work and to share both successful
and less successful pedagogical episodes. One surprising result is the teachers’
conscious efforts to help the students adopt strategies for learning.
Temozolomide Combined with Radiotherapy Can Benefit Patients with Glioma: A Systematic Review and Meta-Analysis
Authors: huang Qinhong , Yang Lihui , Ye Zhenwei , Yang Jing , Ke Yiquan
Published: March 2023

Background: Glioma originates from glial cells of the nervous system and is the most common malignant tumor in the brain. Temozolomide is considered as a promising medicine that can improve the overall survival (OS) and progress-free survival (PFS) rate of patients with glioma after operation. However, whether radiotherapy plus temozolomide has substantive role for glioma patients remains controversial.
Methods:We conducted a meta-analysis included 10 Randomized controlled trials (RCTs) encompassing 2703 patients to evaluate the efficacy and safety of radiotherapy plus temozolomide for glioma. EMbase, PubMed, Web of Science, and Cochrane library were searched. Our study strictly follows the PRISMA guideline.
Results:Overall, compared with receiving radiotherapy alone, patients through radiotherapy combined with temozolomide has substantial benefit on both OS (HR=0.78; 95% CI: 0.62-0.98; P =0.03) and PFS (HR=0.62; 95% CI: 0.49-0.78; P <0.0001). The best effect shows in patients receiving radiotherapy combined with both concurrent and adjuvant temozolomide on both OS (HR=0.66; 95% CI: 0.58-0.74; P <0.00001) and PFS (HR=0.55; 95% CI: 0.48-0.62; P <0.00001), when compared with radiotherapy alone. Whereas, temozolomide monotherapy do not show greater benefits than radiotherapy alone on OS (HR=0.93; 95% CI: 0.74-1.14; P =0.53). Moreover, radiotherapy plus temozolomide obviously increase the incidence of hematological complications than only radiotherapy (RR=10.31; 95% CI: 4.49-23.71; P<0.00001). Also, our meta-analysis suggested that MGMT methylation test can be helpful for evaluating prognosis, determining individualized treatment and forecasting the curative effect.
Conclusion:Radiotherapy combined with temozolomide, especially combined with both concurrent and adjuvant temozolomide has great benefit on both OS and PFS of glioma patients. Conditionally, patients with glioma receiving glioma MGMT methylation test have advantage over evaluating prognosis, determining individualized treatment and forecasting the curative effect. Last but not least, monitoring blood routine and remedying the possible abnormalities in time is especially necessary of patient receiving temozolomide therapy.
Contextualizing the Revised Patient Perception of Patient-Centeredness (PPPC-R) Scale in Primary Healthcare settings: a Validity and Reliability Evaluation Study
Authors: Cai Yiyuan , Guo Pengfei , Tu Jiong , Hu Mengyao , Liu Lingrui , Ryan Bridget L. , Liao Jing , Dev Rubee , Li Yiran , Huang Tianyu , Wang Ruilin , Li Kuang , Huang Ruonan , Li Xinfang , Melipillán Edmundo Roberto , Zhao Shuaixiang , He Wenjun , Wang Xiaohui , Zhang Nan , Xu Dong（Roman）
Published: March 2023

Background The Patient Perception of Patient-Centeredness (PPPC) scale in English was recently revised, and it is necessary to test this instrument in different primary care populations.
Aim This study aimed to assess the validity and reliability of a Chinese version of the PPPC scale.
Design Delphi method was used to address the content validity of the PPPC scale by calculating the Content Validity Index, Content Validity Ratio, the adjusted Kappa, and the Item Impact Score. Confirmatory factor analysis (CFA) and exploratory factor analysis (EFA) were used to assess the construct validity of the PPPC scale. The internal consistency was also assessed.
Setting/participants A cross-sectional survey included 188 outpatients in Guangzhou city and 108 outpatients in Hohhot city from community health service centers or stations.
Results The 21 items in the scale were relevant to the component they belong to. The Item-level Content Validity Index for each item was higher than 0.79, and the average Scale-level content validity index was 0.97 in each evaluation round. The initial proposed 4-factor CFA model did not fit adequately. Still, we found a 3-factor solution based on our EFA model and the validation via the CFA model (model fit:χ2=294.573, P<0.001, RMSEA=0.044, CFI=0.981; factor loadings: 0.553 to 0.888). Cronbach's α also indicated good internal consistency reliability: The overall Cronbach's α was 0.922, and the Cronbach's α for each factor was 0.851, 0.872, and 0.717, respectively.
Conclusions The Chinese version of the PPPC scale provides a valuable tool for evaluating patient-centered medical service quality.
Determination of Online Thin Film Buckling Configuration by Parametric Optimization for Flexible Sensor Application
Authors: Kim Yeoun-Jae , Wi Daehan , Kim Jingyu , Choi Jaesoon
Published: March 2023

The thin film flexible sensor has applications in the medical field in measuring the electro cardiography (ECG) signals to localize and quantize the physiological condition/status of heart. Owing to the flexible nature of the thin film, its configuration changes with respect to the contact boundary condition when it comes in contact with the target surface. Therefore, to accurately localize the flexible sensor, the thin film flexible sensor's configuration must be determined accurately in an on-line fashion. As a study of localizing the thin film flexible sensor, this study proposes an on-line thin film buckling configuration determination method using parametric optimization and interpolation technique. With the specific modulus of elasticity and dimensions of the thin film flexible sensor of the mapping catheter prototype, the buckling configuration with two point boundary condition under axial load can be calculated online with approximately 0.1 mm absolute ya value error compared with that of the experiment. The result of the proposed method is also compared with that of the numerical simulation by ANSYS, which has approximately 0.4 mm absolute ya value error compared with that of the experiment.
Rapid detection of goose astrovirus genotypes 2 using real-timereverse transcription recombinase polymerase amplification
Authors: Li Haiqin , Zhu Yujun , Wan Chunhe , Wang Zhangzhang , Liu Lei , Tan Meifang , Zhang Fanfan , Zeng Yanbing , Huang Jiangnan , Wu Chengcheng , Huang Yu , Kang Zhaofeng , Guo Xiaoqiao
Published: March 2023

Background
Goose astrovirus (GoAstV) is an important pathogen that causes joint and visceral gout in goslings. It has been circulating in many provinces of China since 2017. Goose astrovirus genotypes 2 (GoAstV-2) is the main epidemic strain, and its high morbidity and mortality have caused huge economic losses to the goose industry. An accurate point-of-care detection for GoAstV-2 is of great significance. In this study, we developed a real-time reverse transcription recombinase polymerase amplification (RT-RPA) method for the on-site detection of GoAstV-2 infection.
Results
The real-time RT-RPA reaction was carried out at a constant temperature of 39°C, and the entire detection time from nucleic acid preparation to the end of amplification was only 25 min using the portable device. The results of a specificity analysis showed that no cross-reaction was observed with other related pathogens. The detection limit of the assay was 100 RNA copies/µL. The low coefficient of variation value indicated excellent repeatability. We used 270 clinical samples to evaluate the performance of our established method, the positive concordance rates with RT-qPCR were 99.6%, and the linear regression analysis revealed a strong correlation.
Conclusions
The established real-time RT-RPA assay showed high rapidity, specificity and sensitivity, which can be widely applied in the laboratory, field and especially in the resource-limited settings for GoAstV-2 point-of-care diagnosis.
Faecalibacterium duncaniae A2-165 regulates the expression of butyrate synthesis, ferrous iron uptake, and stress-response genes based on acetate consumption
Authors: Verstraeten Sophie , Layec Séverine , Auger Sandrine , Juste Catherine , Henry Céline , Charif Sawiya , Jaszczyszyn Yan , Sokol Harry , Beney Laurent , Langella Philippe , Thomas Muriel , Huillet Eugénie
Published: March 2023

The promising next-generation probiotic Faecalibacterium
prausnitzii is one of the most abundant acetate-consuming,
butyrate-producing bacteria in the healthy human gut. Yet, little
is known about how acetate availability affects this bacterium’s
gene expression strategies. Here, we show that, in the early
stationary phase, F. duncaniae strain A2-165 (previously
known as F. prausnitzii) can strongly regulate the
expression of metabolic and stress-response genes based on acetate
availability. Using RNA-seq, we compared gene expression patterns
between two growth phases (late exponential vs. early stationary)
and two acetate levels (low: 3 mM vs. high: 23 mM). Remarkably,
transcription levels were high for the gene encoding the MAM
protein, a pattern that was unaffected by acetate levels. At
low-acetate levels, a general stress response was activated, and
protein synthesis expression was down-regulated. At high- acetate
levels, there was greater expression of genes related to butyrate
synthesis and to the importation of B vitamins and iron.
Specifically, expression was strongly activated in the case of the
feoAABC operon, which encodes a FeoB ferrous iron
transporter, but not in the case of the feoABgene, which
encodes a second FeoB transporter. RT-PCR revealed that excess
ferrous iron repressed feoB gene expression. Finally, we
detected FeoB peptides from strain A2-165 in a healthy human fecal
metaproteome. In conclusion, we characterized two early stationary
lifestyles for F. duncaniae A2-165 that relate to acetate
consumption. Through multiomics and targeted approaches, this work
highlights the crucial role that the feoAABCoperon might
play in iron homeostasis in acetate-rich environments.
Impact of the COVID-19 pandemic on women living with and beyond breast cancer: a qualitative study of women’s experiences and how they varied by social determinants of health
Authors: Myers Charlotte , Waldron Catherine , Bennett Kathleen , Cahir Caitriona
Published: March 2023

Background
The aim of this study is to explore the general impact of COVID-19 on the access and use of BC services and support and overall well-being in women living with a diagnosis of breast cancer (BC) and to investigate how these experiences varied by the social determinants of health (SDH).
Methods
Semi-structured qualitative interviews were conducted with women selected through stratified purposive sampling to ensure data were available on information-rich cases. Interviews were conducted in early 2021 during government restrictions due to COVID-19. Thematic analysis was conducted to obtain overall experience and variation of experience based on SDH.
Results
Thirty seven women participated in interviews. Three major themes, with additional subthemes, emerged from analysis: 1. breast cancer services (screening, active treatment, and routine care); 2. breast cancer support and communication (continuity of care, role of liaison, and support services); and 3. quality of life (QoL) and well-being (emotional well-being; social well-being; and functional well-being). Women’s experiences within the themes varied by socio-economic status (SES) and region of residence (urban/rural) specifically for BC services and support.
Conclusion
The pandemic impacted women living with and beyond BC, but the impact has not been the same for all women. This study highlights areas for improvement in the context of BC care in Ireland and the findings will inform further policy and practice, including standardized BC services, improved communication, and enhancement of cancer support services.
Generation of DNA Oligomers with Similar Chemical Kinetics via In-Silico Optimization
Authors: Tobiason Michael , Yurke Bernard , Hughes William
Published: March 2023

Networks of interacting DNA oligomers are useful for applications such as biomarker detection, targeted drug delivery, information storage, and photonic information processing. However, differences in the chemical kinetics of hybridization reactions, referred to as kinetic dispersion, can be problematic for certain applications. Here, it is found that controlling known factors is sufficient to mitigate most kinetic dispersion. Eliminating complementary base-sequences which are not part of the desired hybridization reaction, referred to as unnecessary duplexes, is key to achieving exceptionally low kinetic dispersions. An analysis of existing experimental data indicates that unnecessary duplexes explain up to 94% of previously reported kinetic dispersion. Nearly all networks are found to contain unnecessary duplexes substantial enough to affect hybridization kinetics. New networks are generated using in-silico optimization, reducing in-vitro kinetic dispersion up to 86%. Limitations of the generation method are tested by creating oligomers for three previously programmed reactions and one previously engineered structure.