bluuebunny/crossref_metadata_2025 huggingface dataset:
Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway
Authors: Sun Fei , Zhou Jian Lin , Wei Si Xing , Jiang Ze Wen , Peng Hao
Published: May 2022

Background

Steroid-induced osteonecrosis of the femoral head (SONFH) is a disorder that causes severe disability in patients and has a high incidence worldwide. Although glucocorticoid (GC)-induced apoptosis of osteoblasts is an important cytological basis of SONFH, the detailed mechanism underlying SONFH pathogenesis remains elusive. PI3K/AKT signaling pathway was reported to involve in cell survival and apoptosis.

Objective

We explored the role of PI3K/AKT/FOXO1 signaling pathway and its downstream targets during glucocorticoid -induced osteonecrosis of the femoral head.

Methods

We obtained gene expression profile of osteoblasts subjected to dexamethasone (Dex) treatment from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were screened out and functional enrichment analysis were conducted by bioinformatics analysis. In vitro, we analyzed Dex-induced apoptosis in MC3T3-E1 cells and explored the role of PI3K/AKT/FOXO1 signaling pathway in this phenomenon by employing siRNA-FOXO1 and IGF-1(PI3K/AKT agonist). Finally, we verified our results in a rat model of SONFH.

Results

In Dex-treated osteoblasts, DEGs were mainly enriched in the FOXO signaling pathway. Dex inhibited MC3T3-E1 cell viability in a dose-dependent effect and induced apoptosis by increasing the expression levels of FOXO1, Bax, cleaved-Caspase-3, and cleaved-Caspase-9, while reducing the expression of Bcl-2. Notably, these results were reversed by siRNA-FOXO1 treatment. Dex inhibited PI3K/AKT signaling pathway, upregulated FOXO1 expression and increased FOXO1 nuclear translocation, which were reversed by IGF-1. Compared to normal rats, the femoral head of SONFH showed increased expression of FOXO1, increased number of apoptotic cells, and empty osteocytic lacunas, as well as decreased bone tissue content and femoral head integrity. Significantly, the effects of GC-induced SONFH were alleviated following IGF-1 treatment.

Conclusion

Dex induces osteoblast apoptosis via the PI3K/AKT/FOXO1 signaling pathway. Our research offers new insights into the underlying molecular mechanisms of glucocorticoid-induced osteonecrosis in SONFH and proposes FOXO1 as a therapeutic target for this disease.
Compliance of the ‘Batas Kasambahay’ (Ra 10361) Among Domestic Employers in Zamboanga Del Norte: Basis for Bureaucratic Intervention
Authors: Mansanadez Evangeline , Lapinig Ruthie Liza
Published: May 2022

Every human being has its own rights and privileges to be enjoyed for a lifetime. To have a happy and secure means of living is always a dream of every individual. This study is designed to determine the compliance of the “Batas Kasambahay” (RA 10361) among domestic employers in Zamboanga del Norte as the basis for bureaucratic intervention. It utilized descriptive normative survey method of research employing the questionnaire as the main data gathering tool; employing frequency count, simple percentage, and Likert’s method of determining the weighted mean; utilizing the 30 kasambahay working in households situated in the Poblacion areas of the towns in the three Congressional Districts within the territorial jurisdiction of the province of Zamboanga del Norte. Findings led to the conclusion that the mandated right to board and lodging and medical attendance, humane treatment, and access to communication were compiled by the majority of the domestic employers. However, their rights for social and other benefits and incentives were not complied with by the latter.
Enriching Formal Visual Analysis among Grade 10 Learners through Quest-Theme Module: An Experimental Study
Authors: Franco Samboy
Published: May 2022

This study was conducted to investigate the effectiveness of using the quest-theme module to enrich the formal visual analysis level of junior high school students in Art. A questionnaire and a teacher-made pretest and post-test were used as primary tools in gathering the data needed in this study. The study found that majority of the student respondents were classified as Level 2 in terms of formal visual analysis and also, most of them were under Approaching Proficiency (AP) category in terms of their academic achievements. Furthermore, the study unconcealed a significant relationship between the formal visual analysis level and the academic performance of the respondents. Findings also showed that pretest results were interpreted as fair. Seemingly, there was no significant difference in the mean scores of the control and experimental group. The study revealed that post-test results from the control group were interpreted as fair while results from the experimental group were described as excellent. Implicitly, the results from the data showed that there was a significant difference between the two variables. It was also found on the pre-test and post-test mean scores analysis that there was a significant difference between the results of the two variables. It discovered the effectiveness of using the quest-theme module to enrich the formal visual analysis.
Meeting our Commitment: School-Based Management System in the lens of School Performance
Authors: Linao Rian , Gosadan Beatriz
Published: May 2022

Advocates of school-based management believe that school performance will improve if educational management is focused on the school level rather than on the division level. This paper aimed to find out if the school-based management system level of implementation significantly influences the school performance. The findings of the study reveal that the level of implementation of the school-based management system of the administrators in the elementary schools of Makilala Districts was at the developing and maturing level. Most of the administrators’ school performance was meeting the standards in the NAT average rating. School-based management system level of implementation in terms of leadership and governance, curriculum and instruction, accountability, and continuous improvement and management of resources significantly influence school performance.  All of these indicators are the best significant predictors of school performance. These results further indicate that the higher is the administrators’ level of implementation on leadership and governance, curriculum and instruction, accountability and continuous improvement, and management of resources, the higher is the level of school performance.
Effect of Deep Cervical Flexor Training on Craniovertebral Angle and Muscle Endurance among Students with Forwarding Head Posture
Authors: Manlogon Jamaica , Villafranca Maurice
Published: May 2022

With the ease of use and a wide variety of choices of smartphones, it significantly affects the ways of life in terms of socializing, applications, gathering, and sharing information. Little do people know that it can also affect posture. This is where an introduction of exercise that targets the muscles involved in the impaired posture comes to maintain a proper posture. This study aimed to evaluate the effect of deep cervical flexor training on the craniovertebral angle and muscle endurance of students with forwarding head posture. The study is an experimental type of research that was utilized on thirty (30) junior high school students who had undergone fishbowl technique selection and were assigned to two (2) groups namely control and experimental group. Craniovertebral angle and deep neck flexor endurance test were used to determine the pre-and post-test of both groups. There is a significant difference in the paired t-test result of the pre-and post-test outcome of deep cervical flexor training of the experimental group in terms of CVA. In contrast to DNFET, there is no significant difference in the paired t-test result of the pre-and post-test intervention of deep cervical flexor training of the experimental group. Deep cervical flexor training is useful to increase CVA.
Assessing the Senior High School Work Immersion with Partner Industries: Basis for Supervisory Work Plan
Authors: Macalintal Irene , De Chavez Criselda
Published: May 2022

The researchers wanted to assess the preparedness of the Grade 12 students for work immersion in terms of punctuality, interpersonal relationship, efficiency, productivity, and safety. The descriptive method of research was used in this study. An online survey was conducted from 48 student respondents from Calamba City Senior High School who graduated during the school year 2017-2018 and 2018-2019 under the STEM strand. The results showed that students were prepared for work immersion in terms of punctuality, interpersonal relationship, and safety measures, as indicated in their responses. They were not as prepared as the first three mentioned indicators when it comes to efficiency and productivity, as revealed in the responses. Problems like the Attitude of superiors towards students, schedule of work, unapproachable co-workers, and tedious work were encountered. Based on the findings, the following conclusions were made: Grade 12 students were prepared for work immersion, and they need more activities to develop themselves to become efficient workers. There were problems encountered by Senior High School students during work immersion with partner industries that need to be addressed in school for them to adapt when they are in the actual workplace easily.
Lived Experiences of Newly Hired Teachers: Basis for Policy Recommendations
Authors: Quimque Ponciana
Published: May 2022

This phenomenological study described the lived experiences of newly hired teachers about their journey towards achieving the goal of imparting knowledge among their students and attaining excellence in their chosen profession. The testimonies of the participants provided bases for policy recommendations. The study was participated by ten (10) teachers who were purposively and randomly sampled among public elementary schools in the Schools Division of Calamba City. The purpose was to obtain participants from the rostrum of teachers with a 5-year length of service. An interview guide question was used during the Focus Group Discussion (FGD). The following themes emerged from the experiences shared by the participants: unprepared, under pressure, high expectations, opportunity, errands, culture shock, accountability, confusion, tradition, challenging, and unequipped. These and all other challenges in classroom management and instructions, students’ behavior and varied abilities, and lack of resources changed the life of newly hired teachers. They coped with all these challenges by doing researches, being updated, asked for technical assistance, and pursuing continuing professional development. Policy recommendations on deployment and handling of newly hired teachers were highlighted: Process of Assigning Tasks among Newly Hired Teachers, Classroom Management and Discipline, and Diversity of Learners, Interruption of Teaching-Learning Process, and Having a Good Start.
A Study on an Effective Detection Method for Ignitable Liquid Residues using FT-IR analysis
Authors: Lim Jang Gyu , choi A-Young , Lee Jeong Min , Lee Sang Gu , Kim Myung Jae , Hwang In Kyu , Kim Jun Sik , Han Dong Hun
Published: May 2022

This study was conducted to identify fire causes through scientific experiments and analysis and to find a new method that can analyze various fire debris. In general, when analyzing fire debris, especially ignitable liquids, GC/MS which is a time consuming and complicated method is used to identify the presence or absence of a fire accelerant(or a ignitable liquid) in a combustion residue. Therefore, in this study, three types of combustion accelerants and fabrics were selected. Fourier transform infrared spectroscopy (FT-IR) of ATR which is both a qualitative and a quantitative chemical analysis method was used for rapid analysis. After preparing samples through fire experiments, a library database was created in the device by measurements of samples and applicability of FT-IR analysis for identifying fire accelerants was identified.
Study on Importance Analysis and Uncertainty Analysis of Fire Probabilistic Safety Assessment in Domestic Nuclear Power Plants
Authors: Ryu Jung-Hyun
Published: May 2022

In Korea, the first of fire Probabilistic Safety Assessment (PSA) was conducted for Hanbit nuclear power plant in 1992. The fire probabilistic safety assessment of a domestic power plant was applied to the methodology and data presented in TR-105928 published in 1995 by EPRI, which separately addresses accident scenarios and conditional core damage frequency. In terms of importance analysis, they performed only a rough assessment of fire area and detailed scenarios that can have a significant impact on the Core Damage Frequency (CDF), but they do not perform uncertainty analysis. In this paper, we present a method for performing importance analysis and uncertainty analysis through a combination of the Minimum Cut Set (MCS) resulting in core damage to nuclear power plants and basic events that form an accident scenario. Based on this, we also presented insights into the basic events that were significantly derived from the fire event probabilistic safety assessment through analysis of switchgear rooms in reference nuclear power plants, and conducted a uncertainty analysis of the CDF. This paper is expected to be available for future Risk-Informed Decision Making (RIDM).
A Study on the Availability of the Toilet Exhaust Port in Apartment Households for Smoke Exhaust
Authors: Cho Sung-Woo
Published: May 2022

This paper suggests a system to reduce suffocation casualties in apartment households by smoke exhaust using the toilet exhaust port adjacent to the outdoor. The opening/closing method of the fire damper attached to the existing systems takes the form “CLOSED” to prevent flame and smoke diffusion, but the method used in the proposed system is contradictory to this method. The results of the legal review of the smoke exhaust system depends on the conformance of the damper performance to legal requirements. Hence, the proposed system can be applied if the damper performance conforms to the legal requirements and the air velocity in the pipe shaft is within the legal velocity limit. However, the exhaust rate of the natural exhaust system must be considered.
Development of the Drone Platform Equipped with Robot Arm and Gripper for Enhancing Safety and Efficiency in Fire-fighting Mission
Authors: Jeong Sanghun , Han Phan Van , Park Hyeongmo , Kim Daljoo , Jung Hoeryong , Chang Handdeut , Kim Yeongjin
Published: May 2022

Recently, drones have been utilized in various fields. The drones for firefighting have the capability to carry out various missions such as delivery of items or assistance. In this paper, we explain the drone with six powerful motors and a multi-functional gripper on the side of the drone used for conducting various missions. The drone body, which is lightweight but with high stiffness, is composed of carbon fibers. We used a PID controller and analyzed acquired sensor data during a flight by using Mission Planner software in order to improve flight stability and safety. The suggested drone could be used in firefighting missions, such as docking to the electric pole or delivering items horizontally using the equipped gripper. In addition, after fixing on the pole, equipped robot arms can conduct missions for workers at high altitude. Therefore, it could provide the safety of the firefighter and survivors.
Soberanía alimentaria, ontologías Diné: ecología política y espiritual como herramientas para la auto-determinación
Authors: Clément Picos Eugenie
Published: May 2022

Este artículo se centra en los diferentes actores involucrados en el movimiento de soberanía alimentaria en la Nación Navajo, Estados Unidos. Al observar primero las raíces históricas de la colonización y el dominio occidental sobre las tierras indígenas y sus sistemas alimentarios, trato de dar una perspectiva sobre el movimiento para terminar con la colonización y el capitalismo. Ambos se consideran vinculados y se consideran obstáculos para la autodeter- 41 minación de los Diné y los pueblos Indígenas en general. Los diferentes actores involucrados (agricultores, activistas, intelectuales y académicos) presentan la soberanía alimentaria como una herramienta clave para la descolonización. Esto podría incluir un cambio estructural en sus vidas políticas y económicas, fricciones con el gobierno tribal y el federal. Las tensiones entre la economía extractiva, los ambientalistas y la soberanía alimentaria están presentes en la nación Navajo e impactan a sus comunidades y la calidad de sus vidas.
Políticas y marco jurídico de fomento a la lactancia materna exclusiva en el Perú
Authors: Baca-Gamarra Ana Miluzka
Published: May 2022

La Organización Mundial de la Salud en su último informe sobre las Metas de Nutrición para el 2025, ha incluido a la lactancia materna, como 5ª meta, proponiendo aumentar la tasa de lactancia materna exclusiva en los primeros 6 meses de vida hasta un 50% como mínimo, para mejorar la tasa de supervivencia y la salud de los infantes, esto ha impulsado a los países miembros de la OMS a incrementar sus esfuerzos para promover su práctica y aumentar las estadísticas de países con cifras menores al 1% de mujeres que practican la lactancia materna exclusiva. Perú, como estado miembro posee una trayectoria en la implementación de disposiciones que han contribuido a mejorar el espíritu de esta meta, posicionándose actualmente en el primer lugar de los países latinoamericanos y segundo lugar a nivel mundial con mayor frecuencia de lactancia materna exclusiva, según UNICEF. El presente artículo tiene como objetivo describir la implementación de disposiciones legales en el Perú, que se relacionan con el incremento de la lactancia materna exclusiva.
Desencuentros entre el imaginario social occidental y el imaginario social indígena: elementos para una reflexión teórica sobre los imaginarios sociales nucleares en el marco del conflicto entre el estado-nación chileno y el pueblo mapuche
Authors: Gallegos Krause Eduardo
Published: May 2022

El presente trabajo de orientación eminentemente teórica tiene por objetivo realizar un diagnóstico mediante un método sintético con énfasis hipotético-deductivo que dé cuenta de cuáles son los imaginarios nucleares del Estado nación chileno, por una parte, y del Pueblo mapuche por la otra, todo esto en el marco del conflicto entre Estado-nación y Pueblo mapuche. La aproximación teórica vincula los imaginarios sociales con la construcción de la identidad y la alteridad, para esto se utilizarán los aportes en torno a los imaginarios sociales desarrollados fundamentalmente por Castoriadis y actualizados por Manuel Antonio Baeza, sin desmedro de otros aportes. El análisis particular de los elementos constituyentes de los imaginarios en estudio permite identificar y caracterizar un imaginario nuclear occidental (del Estado-nación) basado en la idea de modernidad-desarrollo y un imaginario nuclear indígena (del Pueblo mapuche) basado en el principio de renovación con una concepción cíclica y no lineal del tiempo.
El viaje del zorro al cielo y su tío el tigre: Texturas transculturales amerindias en dos repertorios de relatos mapuche del zorro
Authors: Moulian Tesmer Rodrigo
Published: May 2022

El artículo muestra los contenidos transculturales amerindios en dos repertorios de relatos mapuche del zorro. El primero de ellos corresponde al viaje del zorro al cielo, originario del área centro andina. El segundo es el del zorro y su tío el tigre procedente de las narrativas del Chaco. A través de un análisis narratológico, se destaca la recurrencia de los motivos que estructuran las tramas narrativas y dan forma a los relatos. Al respecto argumentamos que la representación del zorro como un personaje transgresor, común en las narrativas, expresa un problema general, por lo mismo, proclive a su simbolización transcultural. Las contradicciones en la conducta del zorro exponen las tensiones entre las necesidades básicas y los impulsos vitales del personaje y las normas culturales para la administración de las mismas, lo que constituye una experiencia común a la condición humana.
Migración y trabajo, una revisión del contexto chileno actual
Authors: Rival Diego , Valenzuela-Valenzuela Amanda , Cartes-Velásquez Ricardo
Published: May 2022

Los flujos migratorios son parte de la historia de Chile, y han tenido cambios a través del tiempo. Actualmente, existen múltiples vulneraciones a los derechos de las personas migrantes, que conllevan a que tengan dificultades para acceder a la esfera laboral. Esto dificulta cumplir el objetivo principal de la migración, correspondiente a mejorar las condiciones de vida. Se exploran en esta revisión bibliográfica los principales motivos para abandonar las naciones de origen; la etnicidad, diversidad cultural y procesos de aculturación; la vulneración de derechos de personas migrantes, destacándose las vulneraciones legales; y el trabajo como fenómeno social, donde se incluye la relevancia de los cursos y talleres de formación laboral para la población migrante. Se concluye que a través de múltiples intervenciones pueden disminuirse las vulneraciones de derechos a las personas migrantes y mejorar sus condiciones de vida, facilitando su acceso a la esfera laboral.
Familias transnacionales desde el sur. Testimonios de la globalización en Chile. Javiera Cienfuegos Illanes (coord.). Ediciones Universidad Academia de Humanismo Cristiano
Authors: Julián Vejar Dasten
Published: May 2022

Reseña: Familias transnacionales desde el sur. Testimonios de la globalización en Chile. Javiera Cienfuegos Illanes (coord.). Ediciones Universidad Academia de Humanismo Cristiano
Desempleo y flexibilización: Alemania Federal y Chile frente a las transformaciones del capitalismo (Décadas de 1970 y 1980)
Authors: Llanos Claudio , González José Antonio , Stillerman Joel
Published: May 2022

Este artículo analiza las respuestas a la crisis de los 1970s y la de 1982, de Chile y Alemania Federal. Crisis que impactaron en contextos diferentes, tanto a nivel de posiciones en la economía capitalista, como en lo referente a los regímenes políticos. En ambos países se plantearon el desempleo y los cambios en los ámbitos del trabajo. En este contexto, en Chile, las turbulencias económicas mundiales, se ligaron a la reacción violenta de los militares a la “vía chilena al socialismo” que, en alianza con las grandes empresas y economistas neoliberales, permitieron el desarrollo de las políticas neoliberales. Alemania Federal respondió al final del “milagro económico” de la posguerra con políticas gradualistas que preservaron el Estado del bienestar. La economía coordinada de Alemania Federal y la influencia de los sindicatos dentro de los dos grandes partidos políticos postergaron la aplicación de estas políticas hasta los 2000. La comparación demuestra la importancia de las configuraciones políticas de cada país para explicar sus políticas económicas y sociales frente a cambios de la economía global. De esta forma, se evidencia que la política es el campo de construcción de las diversas alternativas frente a las dinámicas del capitalismo.
Relaciones de reconocimiento en un trabajo feminizado. Ejes analíticos a partir del caso de mujeres operarias de la industria chilena del retail
Authors: Guerra Arau Rodrigo , Calquín Donoso Claudia Alejandra
Published: May 2022

En este artículo se discute sobre las dinámicas de reconocimiento en empleos feminizados, en particular en el sector de los servicios. En base a la teoría del reconocimiento de Honneth y otros autores, se presentan tres ejes de análisis de las dinámicas de reconocimiento conformadas tanto a partir de particulares configuraciones sociotécnicas del trabajo, como en función de estructuras sociales de género y clase. Se toma como caso los colectivos de cajeras de grandes cadenas de supermercado y vendedoras de tiendas por departamentos en Santiago de Chile.
De la subordinación asalariada a la caridad neoliberal: análisis crítico de la ley de inclusión laboral de personas con discapacidad en Chile
Authors: Cea Madrid Juan Carlos
Published: May 2022

El presente artículo analiza la entrada en vigencia de la Ley Nº 21.015 “Incentiva la inclusión de personas con discapacidad al mundo laboral”. Esta normativa tiene por finalidad mejorar la empleabilidad de las personas con discapacidad en entornos laborales abiertos por medio de la reserva del 1% de la cuota de empleos en empresas con 100 o más trabajadores. Al respecto, se examinan las limitaciones de esta política de acceso al empleo para la promoción del derecho al trabajo y la configuración de sociedades más inclusivas. De acuerdo con un análisis crítico de la implementación de la iniciativa legal en el sector privado, se observan brechas salariales, etarias y de género en la incorporación y permanencia de las personas con discapacidad en el mercado de trabajo. Finalmente, se concluye que las estrategias de inserción laboral en el campo de la discapacidad no cuestionan las estructuras de poder en la sociedad capitalista y se integran a las bases del modelo neoliberal en el Chile contemporáneo.
Seed Germination, Vegetative Growth and Flowering Performance of Cockscomb (Celosia cristata L.) in Response to Different Potting Media
Authors: Ahmed Waleed , Ali Barkat , Kumar Sujon , Memon Noor-Un-Nisa , Wahocho Niaz Ahmed , Miano Tanveer Fatima , Memon Mehr-Un-Nisa
Published: May 2022

The experiment was carried out at the Horticulture Garden, Department of Horticulture, Sindh Agriculture University, Tandojam, Pakistan, during the cropping season March 2017 to May 2017. To estimate germination percentage, vegetative growth and flowering performance of Cockscomb (Celosia cristata L.) in response to different potting media. Aim of the research was to evaluate the best potting media and select the best segregating genotype of Cockscomb for superior performance on flowering traits. The trial was laid out in randomized complete block (RCBD) with three replications. The experiment consisted with two genotypes G1 (Amigo Red) and G2 (Prestige scarlet) were planted in different potting media T1 (100% Canal sediment), T2 (75% Canal sediment + 25% FYM), T3 (50% Canal sediment + 50% Coco peat), T4 (25% Canal sediment + 50% bagasse + 25% Coco peat) and T5 (25% Canal sediment + 70% bagasse + 5% Coco peat) in the earthen pots. Our present findings of genotype (G2) in potting media (T4) indicated highest seed germination percentage (87.50%), germination index (1.77), plant height (36.55 cm), seedling vigor index (3394.2), fresh weight of shoot (56.40 g), fresh weight of root (13.35 g), fresh weight of a single flower (16.97 g), days taken to initiate flowering (74.88 days), number of flowers per plant (5.05) and chlorophyll content of leaf (36.08%). To compare mean of the G2 obtained better results in comparison to genotype (G1). The interaction of the genotypes and potting media was highly significant in G2 from the plants grown in (T4) potting media. This study showed that based on the potting media performance of the Cockscomb genotypes found maximum performance in (T4) potting media at Tandojam location. Others potting media along with genotypes and geographical locations might be explored for future research activities.
The Use of Pottasium Diformate in Feed to Improve Immunity Performance of Common Carp (Cyprinus carpio, L)
Authors: Yustiati Ayi , Riyani Awalia , Sunarto . , Suryadi Ibnu Bangkit Biohina
Published: May 2022

This research aims to determine the optimum potassium diformate (KDF) dosage which was added to commercial feed to increase the immune performance of common carp fingerlings (Cyprinus carpio L). This study was conducted from October – December, 2021 at the Laboratory of Aquaculture and Molecular Biotechnology of The Faculty of Fisheries and Marine Sciences, Universitas Padjadjaran. The method used in this research was experimental in a Completely Randomized Design (CRD) with 5 treatments and 3 replications. The treatments are A (without KDF as control), B (0.2% KDF), C (0.3% KDF), D (0.4% KDF) and E (0.5% KDF). The observed parameters are total leukocyte count, total erythrocyte count, and gross clinical symptoms. Observations were made for 35 days after KDF administration and then challenged by Aeromonas hydrophila for 14 days. Total leukocyte count and total erythrocyte count were analyzed using ANOVA and DMRT at a 95% confidence level, while the gross clinical symptoms was analyzed descriptively. The results showed that the of 0.3% KDF was the most effective dose to increase the immune performance of common carp, the result showed that the total leukocyte count, and total erythrocyte count had the highest increase of 22,95% and 20,55%. In addition, the process of recovering is faster than other treatments it can be shown by the symptoms healing time and number of total leukocyte count and total erythrocyte count are approaching normal condition, with a value of 8,38 × 104 cells/mm3, and 1,46 × 106 cells/mm3.
Medication Reconciliation in Surgical Patient Admitted at Tertiary Care Hospital of Northern India
Authors: Paljor Yoel Dewa
Published: May 2022

Objective: Medication reconciliation is a formal procedure that includes compiling the most correct and comprehensive list of a patient’s current medications and comparing it to those listed in the patient’s medical record. This study aims to evaluate the pattern of Medication Reconciliation programme in our hospital. A retrospective observational study was carried out over a period of 6 months (Jan-2021 to Jun-2021) in department of surgery of SSB Heart and Multispecialty Hospital.

A total of 1700 patients were eligible among which 64.17% cases were found to be compliant and remaining 35.82% were non-compliant, which may be due to incomplete information from the patients and frequent change in staff. A continued education of the staff and proper communication with the patient is strongly recommended.
Effect of Spacing and Biofertilizer on Yield and Economic of Black Gram (Vigna mungo L.)
Authors: Sasidhar Peruru , Singh Shika , Naidu Bevara Asiri , Chandra Y. Rajeeva Subash , Malleswari S. , Mohan Neeraganti
Published: May 2022

A field experiment was carried out during zaid season of 2021 at crop research farm of SHUATS, Prayagraj to study about the Effect of Spacing and Biofertilizer on growth and yield of Black gram (Vigna mungo L.) The experiment was laid out in randomized block design by keeping three spacing levels, i.e. S - (20 x 10 cm), S2 – (25 x 10 cm) and S3 – (30 x 10 cm) and Biofertilizers i.e. PSB and Rhizobium and which was replicated three. Results revealed that spacing of 30 x 10 cm + Rhizobium , PSB  recorded significantly higher in plant height (43.88 cm), number of branches per plant  (6.81),  number of nodules per plant (25.84), number of pods per plant (37.30), number of seeds per pod (7.51) test weight (37.73 g), grain yield (836 kg/ha) and stover yield (2144 kg/ha) and plant dry weight (6.77 g/plant), crop growth rate results are  showed in 20 x 10 cm + Rhizobium + PSB. However, net returns (54550.00 INR/ha) and B:C ratio (2.62) was also obtained with the application of spacing 30 x 10 cm + Rhizobium + PSB. Therefore I concluded that spacing of 30 cm x 10 cm + Rhizobium + PSB was produced more grains (836 kg/ha) and economic effect (2.62).
Influence of Humic Acid and Vermicompost on Vegetative and Flowering Performances of African Marigold cv. Seracole in Indo-Gangetic Plains of West Bengal
Authors: Ghosh Tushar , Maherukh Karishma , Chowni Suraranjan , Pal Arun Kumar
Published: May 2022

The present investigation was performed in Horticultural Research Station, Mondouri, Bidhan Chandra Krishi Viswavidyalaya, Nadia, West Bengal during 2017 to 2018 to assess the best dose of humic acid and vermicompost combination for African marigold. The experiment was designed in Randomised Block Design (RBD) with three replications. There were four concentrations of humic acid extracts (0.5 g/l, 1.0 g/l, 1.5 g/l and 2 g/l) applied as a foliar spray in combination with basal doses of vermicompost (1 kg/m2 and 2 kg/m2). All the parameters showed significant differences regarding vegetative, flowering as well as quality parameters. The results indicated that foliar spray with 1.5 g/l of humic acid extract along with 2 kg/m2 vermicompost significantly increased plant height (54.54 cm), number of primary branches (7.21), flower diameter (7.44 cm), fresh weight & dry weight of flower (9.06 g & 1.2 g respectively), number of flowers per plant (84.16), yield per hectare (47.01 tons/ha) as well as the quality parameters. So, among the nine treatments, T8 (Humic acid 1.5 g/l + 2 kg vermicompost/m2) was the best combination for improving plant growth, yield and quality of African marigold in the Indo-Gangetic plains of West Bengal.
The Trajectory of Evolution of State Participation in Natural Resources in Developing Nations under International Law: The Nigerian Experience
Authors: Akabuiro Dominic Obilor
Published: May 2022

The growth and development of a nation largely depends on how its natural resources are utilized for the good of the people. However, the narrative in some developing countries, particularly Nigeria is scary and this has birthed huge concerns on the global scene. The aim of this paper is to examine the history and growth of natural resource development by States for the betterment of the people in selected oil countries with emphasis on Nigeria. Nigeria’s experience with state participation in the development of its natural resources is uniquely discussed in this paper because; Nigeria being the most populous African nation and having the largest oil and gas deposits in Africa still has almost half of its population living below the poverty line.

The study examined state participation in four different jurisdictions including; Venezuela, Indonesia, Angola and Nigeria. Focus is placed on the Nigeria experience. The study adopted a qualitative and doctrinal research methodology.

At the root of all these frictions with natural resource development in Nigeria is the State’s inadequate policy and control with emphasis on localization to ensure that the center holds.

Nigerian state’s participation in natural resource development has grown from mere participation agreement to state corporation participation as a player in the oil and gas industry. Indigenous companies being enabled by the local content legislation have actively participated in the development of natural resources. However, while the aim of state participation in the development of natural resource is to improve the social and economic wellbeing of citizens, it goes without saying that the Nigerian people are fettered with resource injustice of which the state is culpable. It is not new that Nigeria still lacks and pays heavily for what it produces in abundance. It is called the resource curse syndrome.
Evaluation of the Abnormalities of Lipid Profile in Patients with Cholelithiasis
Authors: Jabeen Sadaf , Sial Ihsanullah , Shakeel Sabohi , Shaikh Khurram , Melwani Rekha , Sarwar Ghulam , Anis Syed Samir , Iqbal Kashmala M.
Published: May 2022

Objective: Cholelithiasis is a chronic recurrent illness that affects the hepatobiliary system. Gall stone formation is caused by the impaired metabolism of cholesterol, bile acids and bilirubin. Hence, the aim of this study was to compare the serum lipid parameters of gallstone patients with the control group.

Methodology: This was a Case control study conducted in surgical department of Sindh Government Hospital Korangi 5 by using convenient sampling technique. The duration of the study was about 06 months. A total of 54 patients aged above 15 years of both the genders wherein 28 patients diagnosed with Gallstone disease were considered as case group and 29 patients with no history of gallstones as controls were included in the study. Demographic characteristics such as age, gender and Continuous variables such as lipid parameters (HDL-C, VDL-C, VLDL-C, TGs, TC) were documented as frequencies and percentages. Student’s t-test was used to compare the data between the cases and the control groups.

Results: The study results showed that out of 54 patients, 44(81.5%) were female and 10(18.5%) were male. Lipid profile of the cases and controls revealed that serum VDL-C was significantly higher (p=0.014) in control group 17(31.5%) as compared to cases 8(14.8%). most of the patients of case group 26(48.1%) had serum HDL-C levels between 35-45 mg/dl as compared to the controls 8(14.8%) with a statistically significant difference between them (p=0.001). Moreover, higher serum TGs levels > 200 mg/dl observed in 1(1.9%) patients in case group and 7 (13.0%) in controls with statistically significant difference between them (p=0.006)

Conclusion: This study concluded that the significant association observed between gallstones and abnormal lipid levels among controls and cases. Therefore, it was depicted that the risk of cholelithiasis increased with discrepancies in lipid profiles.
Effects of Anti-inflammatory Medication on Indoleamine 2,3 Dioxygenase Activity
Authors: Dawood Shazia , Bano Samina , Sundus Sadia , Aijaz Asma , Samreen Talat , Usmani Mohsin Ali
Published: May 2022

Objective: To study the effects of anti-inflammatory medication on Indoleamine 2,3 dioxygenase activity.

Research Design: This was an investigational study.

Methodology: Eighteen fully grown albino rats separated into control and two treated sets, both treated sets were given indomethacin (50mg/1000g) orally. For acute treatment first treated set was sacrificed after 3.5 hrs & for chronic treatment second set was sacrificed after 3 days. However, control set animals were given an equivalent amount of vehicle.

Results: Outcomes shows that serum Indoleamine 2,3 dioxygenase (IDO) enzyme activity was suppressed after acute treatment while serum IDO activity were increased after chronic treatment however no significant effect was seen on brain IDO.

Conclusion: It is concluded that indomethacin has not shown any significant effect on brain IDO. But inhibits serum IDO activity.
Ageing and cancer: a research gap to fill
Authors: Solary Eric , Abou‐Zeid Nancy , Calvo Fabien
Published: May 2022

The complex mechanisms of ageing biology are increasingly understood. Interventions to reduce or delay ageing‐associated diseases are emerging. Cancer is one of the diseases promoted by tissue ageing. A clockwise mutational signature is identified in many tumours. Ageing might be a modifiable cancer risk factor. To reduce the incidence of ageing‐related cancer and to detect the disease at earlier stages, we need to understand better the links between ageing and tumours. When a cancer is established, geriatric assessment and measures of biological age might help to generate evidence‐based therapeutic recommendations. In this approach, patients and caregivers would include the respective weight to give to the quality of life and survival in the therapeutic choices. The increasing burden of cancer in older patients requires new generations of researchers and geriatric oncologists to be trained, to properly address disease complexity in a multidisciplinary manner, and to reduce health inequities in this population of patients. In this review, we propose a series of research challenges to tackle in the next few years to better prevent, detect and treat cancer in older patients while preserving their quality of life.
Copper‐triazine‐dendrimer‐functionalized‐graphene oxide: Synthesis, characterization, and application in green synthesis of propargylamines
Authors: Kumar Akash , Kujur Shelly , Kujur Jyoti Prabha , Sharma Richa , Pathak Devendra Deo
Published: May 2022

A copper‐triazine‐dendrimer‐functionalized graphene oxide (CTD‐GO) is synthesized for the first time. The structure of the dendrimer is confirmed by Fourier transform infrared (FT‐IR), Fourier transform (FT) Raman, powder X‐ray diffraction (PXRD), X‐ray photoelectron spectroscopy (XPS), energy‐dispersive X‐ray spectroscopy (EDX), field emission scanning electron microscopy (FESEM), high‐resolution transmission electron microscopy (HRTEM), elemental mapping, atomic absorption spectroscopy (AAS), and thermogravimetric analysis (TGA). The catalytic activity of the CTD‐GO is demonstrated in green synthesis of a series of propargylamine derivatives in high yields via A3‐coupling of aldehyde, alkyne, and amine in water. After the reaction, the catalyst was easily recuperated from the reaction mixture and reused up to four times without any significant loss in its catalytic activity. Operational simplicity, high yields of product, use of green solvent, facile recovery and recyclability of the catalyst, and easy workup are the salient features of this procedure.
Influence of reducing agents in nanoparticle synthesis: SnO2‐ZnO composite anode
Authors: Lakshmi D. , Diana M. Infanta , Manoj Gayathri , Jayapandi S. , Nalini B. , Selvin P. Christopher , Balraju P.
Published: May 2022

The present research work is dedicated to understand the effect of synthesis medium on the nanocomposite anode, SnO2: ZnO, and their synergistic effects towards Li‐ion battery applications. Alkaline and acidic media as reducing agents such as NaOH, LiOH, and NaBH4 are chosen for the preparation of the composite, and the results are surprisingly varying. Structural analysis by means of X‐ray diffraction shows the mixed crystal symmetry inclusive of SnO2 and ZnO phases for all the three systems with varying ranges of each phases. The average crystallite sizes are around 20–39 nm for all the three samples. Morphological analysis of SnO2: ZnO anode by means of transmission electron microscopy indicates mixed shapes of grains for the samples synthesized by NaOH and LiOH, whereas reducing agent, NaBH4, falls into the spherical shape predominantly. Raman and selected area electron diffraction analyses validate the mixed crystal symmetry of all the three samples. Electrochemical performance of the samples is promising where NaBH4 mediated anode delivers reversible capacity around 225 m Ahg−1 exclusively. In the aspect of electrical conductivity, almost all the three samples employed with three different reducing agents fall in the range of ~10−4 S cm−1 at room temperature, validating the choice of the material as anode in Li‐ion battery technology.
Dyad pedagogy in practical anatomy: A description of the implementation and student perceptions of an adaptive approach to cadaveric teaching
Authors: Cullinane Dearbhla P. , Barry Denis S.
Published: May 2022

Prior to the challenges imposed by the Covid‐19 pandemic, anatomy practical sessions at Trinity College Dublin involved eight to 10 students per donor station, rotating between digital learning, anatomical models/osteology, and dissection activities for three hours weekly. To maintain cadaveric participation in the anatomy laboratory while adhering to distancing guidelines, a transition to dyad pedagogy was implemented. This mode of delivery allowed two students per donor station to spend one hour per week in the anatomy laboratory with all digital learning elements transferred to the virtual learning platform Blackboard as pre‐ and post‐practical session learning activities. Dyad pedagogy has been explored in clinical settings and simulation procedural‐based training but is yet to be fully verified in anatomy education. To determine the effectiveness of hybrid practical sessions and reduced donor to student ratios, the opinions of first year medical students were examined using an online questionnaire with a 51% response rate. Although students recognized the merits of more time in the anatomy laboratory, including opportunities for self‐directed study and exposure to anatomical variation, they felt that having two students per station enabled sufficient hands‐on time with the donor body and fostered learning opportunities that would not be possible with larger groups. Strong preferences for quality time with the donor body supported by online resources suggests this modality should be a key consideration in course design for anatomy curricula and emphasizes the importance of gauging students' preferences to optimize satisfaction and learning output when pivoting to blended learning strategies in anatomy education.
Characterizing and Mitigating Cyanobacterial Blooms in Drinking Water Reservoirs
Authors: Adams Hunter , Smith Stephanie A. , Reeder Sam , Appleton Emily , Leinweber Butch , Forbes Steve , Barrowman Polly , Ford Greg , Ikehata Keisuke , Southard Mark
Published: May 2022

Key Takeaways

Successful detection and treatment of cyanobacterial blooms benefit from a thorough understanding of them.

The sooner a harmful algal bloom is detected and identified, the easier and less expensive it will be to eliminate it.

Many tools are available to refine monitoring and mitigation methods; research and technological advances continue to help support water utilities’ efforts.

A laboratory in Wichita Falls, Texas, has developed a proactive, multifaceted approach to address the complexities of monitoring and mitigating blooms.
Relationship between seasons and postpartum depression: A systematic review and meta‐analysis of cohort studies
Authors: Tung Tao‐Hsin , Jiesisibieke Dina , Xu Qinyi , Chuang Yen‐Ching , Jiesisibieke Zhu Liduzi
Published: May 2022

Objective

As the reproduction season's effect on the mental health status is unknown, this study aims to explore the association between seasons and postpartum depression.

Methods

A comprehensive search in databases, including PubMed, Cochrane Library, and EMBASE, was performed to identify studies reporting the relationship between reproduction season and postpartum depression. The latter was assessed using certain methods. Moreover, the study design and duration, sample size, the definition of four seasons, outcome assessment, method, and conclusion were extracted. Two independent authors screened the studies independently, and PRISMA 2020 was used as the reporting standard (PRISMA registration ID is 284524).

Results

A total of five studies including 103,986 participants met our criteria. In the sensitivity analysis, the result of the meta‐analysis shows that women who gave birth in spring, summer, or autumn had a lower risk of postpartum depression compared to those who gave birth in winter (RR: 0.83; 95% confidence interval [CI]: 0.78–0.88).

Conclusion

Women who gave birth in the other seasons were less likely to have postpartum depression compared to those who gave birth in winter. This result could help couples make overall decisions and help the puerpera take preventive measures against postpartum depression.
Steering the Selectivity of Electrochemical CO2 Reduction in Acidic Media
Authors: Xu Zhanyou , Sun Mingzi , Zhang Zhongshuo , Xie Yi , Hou Hongshuai , Ji Xiaobo , Liu Tianfei , Huang Bolong , Wang Ying
Published: May 2022

Improving carbon utilization efficiency is the key to developing next‐generation electrolysers for CO2 reduction reaction (CO2RR). The current CO2RR electrolyser relies on the use of neutral/alkaline media to suppress the competitive hydrogen production and improve the activity of CO2RR. However, the produced carbonate/bicarbonate leads to severe carbon loss. Performing CO2RR in acidic media can suppress the carbonate formation while hydrogen production is the major issue. Herein, we found that the activity of acidic CO2RR can be well tuned through electrolyte optimization on Cu and Ag catalyst. DFT calculation suggests that this results from the change of local electronic structure on Cu by surface adsorbed alkali metal ions. Electrolytes with high content of K+ promote the overall CO2RR activity, especially multi‐carbon production in acidic media. CH4 is the dominant product in Na+ only electrolyte on Cu, with a Faradaic efficiency of 48 % at 220 mA cm−2 in pH=2 solution.