bluuebunny/crossref_metadata_2025 huggingface dataset:
İş Stresinin İşe Yabancılaşma Üzerindeki Etkisi: Örgütsel Destek Algısının Rolü (The Influence of Work Stress on Work Alienation: The Role of Perceived Organizational Support)
Authors: Eren Gülçin , Ece Şafak , Eren Gülçin
Published: July 2022

Amaç –Bu çalışmanınamacıişstresinin işe yabancılaşma üzerindekietkisini ve örgütsel destek algısının bu etkiüzerinde moderatör role sahip olup olmadığınıincelemektir. Birdiğer amaç ise iş stresinin, işe yabancılaşmanın ve örgütsel destek algısının demografik özelliklere göre farklılık gösterip göstermediğiniortaya koymaktır.Yöntem –Bu çalışma nicel bir çalışma olup tarama desenine sahiptir.Çalışma kapsamında kolayda örnekleme tekniği ile İstanbul’da çalışan285 bireye ulaşılıp 10.08.2021-18.12.2021tarihleri arasında çevrimiçi anket uygulanmışve eldeedilen veriler SPSS 21.0 paket programı yardımıyla analizedilmiştir.Bulgular –Çalışma sonuçları, iş stresininişe yabancılaşmaya etki ettiğinigöstermektedir. Örgütsel destek algısının bu etki üzerinde düzenleyici rolü bulunmamakla birlikte işstresi ve işe yabancılaşmaüzerinde ayrı ayrı etkilidir. Ayrıca işeyabancılaşmanın bazı sosyo-demografik özelliklere göre anlamlıbir farklılık gösterdiğisaptanmıştır.Tartışma –Alanyazınla tutarlı olarak buçalışmada da iş stresininişe yabancılaşmanın bir öncülü olduğubelirlenmiştir.Çalışanlarınişe yabancılaşmayaşamamaları için iş stresinin önlenmesi gibitedbirler alınırsa işletme açısındanortaya çıkabilecekolan olumsuzlukların önüne geçilebilir.
On Ziegler Effect with Arbitrary Large Viscous Friction
Authors:   Moscow Aviation Institute (National research university), Krasil’nikov P. S. ,   Moscow Aviation Institute (National research university), Maiorov A. Yu.
Published: July 2022

We study a mechanical system with two degrees of freedom simulating the motion of rotor blades on an elastic bushing of a medium-sized helicopter. For small values of some problem parameters, the destabilizing effect due to small linear viscous friction forces has been studied earlier. Here we study the problem with arbitrary large friction forces for arbitrary values of the problem parameters. In the plane of parameters, the regions of asymptotic stability and instability are calculated. As a result, necessary and sufficient conditions for the existence of a destabilizing effect under the action of potential, follower forces and arbitrary friction forces have been obtained. It is shown that, if some critical friction coefficient $k_{*}$ tends to infinity, then there exists a Ziegler area with arbitrarily large dissipative forces.
Homotopy Analysis Method and Time-fractional NLSE with Double Cosine, Morse, and New Hyperbolic Potential Traps
Authors:   University of Calcutta, Department of Applied Mathematics, Ghosh U. ,   Kodalia Prasanna Banga High School (H.S.), Das T. ,   University of Calcutta, Department of Applied Mathematics, Sarkar S.
Published: July 2022

A brief outline of the derivation of the time-fractional nonlinear Schrödinger equation (NLSE) is furnished. The homotopy analysis method (HAM) is applied to study time-fractional NLSE with three separate trapping potential models that we believe have not been investigated yet. The first potential is a double cosine potential $[V(x)=V_{1}\cos x+V_{2}\cos 2x]$, the second one is the Morse potential $[V(x)=V_{1}e^{-2\beta x}+V_{2}e^{-\beta x}]$, and a hyperbolic potential $[V(x)=V_{0}\tanh(x)\sech(x)]$ is taken as the third model. The fractional derivatives and integrals are described in the Caputo and Riemann Liouville sense, respectively. The solutions are given in the form of convergent series with easily computable components. A physical analysis with graphical representations explicitly reveals that HAM is effective and convenient for solving nonlinear differential equations of fractional order.
Elevated CO2 and Water Stress in Combination in Plants: Brothers in Arms or Partners in Crime?
Authors: Shanker Arun , Gunnapaneni Deepika , Bhanu Divya , Vanaja M , Jyothilakshmi N , Yadav S.K , Prabhakar M , Singh V.K
Published: July 2022

The changing dynamics in climate is the primary and important determinant of agriculture productivity. The effects of this changing climate on overall productivity in agriculture can be understood when we study the effects of individual components contributing to the changing climate on plants and crops. Elevated CO2 (eCO2) and drought due to high variability in rainfall is one of the important manifestations of the changing climate. There is a considerable amount of literature that addresses climate effects on plant systems from molecules to ecosystems. Of particular interest is the effect of increased CO2 on plants in relation to drought and water stress. As it is known that one of the consistent effects of increased CO2 in the atmosphere is increased photosynthesis, especially in C3 plants, it will be interesting to know the effect of drought in relation to elevated CO2. The potential of elevated CO2 ameliorating the effects of water deficit stress is evident from literature suggesting that these two are agents are brothers in arms protecting the plant from stress rather than partnering in crime, specifically water deficit when in isolation. The possible mechanisms by which this occurs will be discussed in this minireview. Interpreting the effects of short-term and long-term exposure of plants to elevated CO2 in the context of ameliorating the negative impacts of drought will show us the possible ways by which there can be effective adaption to crops in the changing climate scenario.
Nonlinear Generalisation of Quantum Mechanics
Authors: Jamali Alireza
Published: July 2022

According to our current understanding of quantum mechanics, a `measurement' violates unitarity. In other words as the act of measurement `resets' the probabilities described by the Schrödinger equation, in the very `moment' of the collapse of the wavefunction, conservation of probability does not hold. To make progress in our understanding of the measurement problem it is thus expected that one must encompass in a single equation both otherwise mutually-exclusive processes of measurement and unitary evolution. In this light, turning to the continuity equation, we realize the possibility that if we allow for existence of sources and sinks in the `fluid of probability' we get closer to such a theory by arriving at nonlinear generalizations of Schrödinger and Klein-Gordon equations. The generalized equations derived are then shown to satisfy all conditions that are expected from a proper generalization: simplification to their linear counterparts by a well-defined dynamical condition, and Galilean and Lorentz invariance.
Proposed Method of Combining Continuum Mechanics With Einstein Field Equations
Authors: Ogonowski Piotr
Published: July 2022

The article proposes an amendment to the relativistic continuum mechanics which introduce the relationship between density tensors and the curvature of spacetime. The resulting formulation of a symmetric stress-energy tensor for a system with an electromagnetic field, leads to the solution of Einstein Field Equations indicating a relationship between the electromagnetic field tensor and the metric tensor. In this EFE solution, the cosmological constant is related to the invariant of the electromagnetic field tensor, and an additional gravitational pull appears, dependent on the velocity of orbiting bodies and the vacuum energy contained in the system. In flat Minkowski spacetime, the vanishing four-divergence of this stress-energy tensor expresses relativistic Cauchy's momentum equation, leading to the emergence of new force densities which can be further developed and parameterized to obtain known interactions. Transformation equations were also obtained between spacetime with fields and forces, and a curved spacetime reproducing the motion resulting from the fields under consideration, which allows for the extension of the solution with new fields.
Kinases and Their Potential as Therapeutic Targets in Huntington’s Disease
Authors: White Angel , McGlone Anna , Gomez-Pastor Rocio
Published: July 2022

Huntington’s Disease (HD) is a devastating neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the HTT gene, for which no disease modifying therapies are currently available. Much of the recent research has focused on developing therapies to directly lower HTT expression, and while promising, these therapies have presented several challenges regarding administration and efficacy. Another promising therapeutic approach is the modulation of HTT post-translational modifications (PTMs) that are dysregulated in disease and have shown to play a key role in HTT toxicity. Among all PTMs, modulation of HTT phosphorylation has been proposed as an attractive therapeutic option due to the possibility of orally administering specific kinase effectors. One of the kinases described to participate in HTT phosphorylation is Protein Kinase CK2. CK2 has recently emerged as a target for the treatment of several neurological and psychiatric disorders, although its role in HD remains controversial. While pharmacological studies in vitro inhibiting CK2 resulted in reduced HTT phosphorylation and increased toxicity, genetic approaches in mouse models of HD have provided beneficial effects. In this review we discuss potential therapeutic approaches related to the manipulation of HTT-PTMs with special emphasis on the role of CK2 as a therapeutic target in HD.
Zoning Strategy for Basin Land Use Optimization for Reducing Nitrogen and Phosphorus Pollution in Guizhou Karst Watershed
Authors: Zhou Xu , Zhang Wenbin , Pei Yu , Jiang Xiao , Yang Shengtian
Published: July 2022

The eutrophication caused by excessive total nitrogen(TN) and total phosphorus(TP) emissions has been widely concerned by the whole society. Studies have revealed the relationship between land use and TN and TP, but the relationship between land use compound topographic position and TP and TN was seldom studied. Therefore, Spearman correlation and redundancy analyses were used to reveal the relationship between land use compound topographic position and TN and TP based on the monthly data of 28 water quality sampling sites and the land use data of 2013 and 2016 in the lakes of Guizhou Plateau. The results show that the nutritional state of the HBA watershed is medium. The trophic level index (TLI) value and TN concentration were high during flood, while TP concentration was high in dry period. The TN concentration in the tributaries was higher than that in the reservoir area. Construction and valley were the sources of the pollution, whereas forest land and gentle slope were the sink. According to the”source-sink”effect, the optimal zoning of land use was completed, and the urban land pollution govern area should be strengthened firstly. This paper can provide decision support for water environment management and sustainable development decision-making.
Systems Dynamics and the Analytical Network Process as A methodology for the Evaluation and Prioritization of Green Projects: A New Proposal that Involves Participative Integration
Authors: Castrillon-Gomez Julian Andres , Olivar-Tost Gerard , Valencia-Calvo Johnny
Published: July 2022

Citizen participation has always been of vital importance in decision-making processes and, likewise, joint work in the formulation and execution of projects that respond to territorial needs. This in order to ensure the best impact of public or private investment, optimizing the result and community articulation. For this reason, this investigation proposes a methodology of evaluation and prioritization of projects based on an approach integrated between the modelling in dynamics systems (SDM) and the Analytical process network (ANP), in which the citizen factors are used as qualitative and quantitative variables inside the posed balance sheet model. This is how the model developed by the Stella Architect software, it offers to the decision makers approximate information about the reality of the community, especially those who were affected by the Colombian conflict and where the expectations of a comprehensive repair could disrupt the socioeconomic system and reveal more pressing interests than those of the central government. The methodology is described by the information gotten through the participatory workshops done in the California county that belongs to the Magdalena region, this is a very affected region by the conflict in Colombia. The investigation results confirm the useful of, first of all, the use of the modelling as an information-generating tool by allowing the simulation of relevant variables in the evaluation and prioritization of projects at different moments of time and, in second place, use the knowledge of the experts that expose the ANP method for establishing the importance of each variable compared with other variables and, likewise of each project compared to the rest of the alternatives in each of the different instants of time in which the evaluation is carried out, given that the results could change in any time, the official ranking is showed after an optimization process with partial results.
Discordance in Addressing Opioid Crisis in Rural Communities: Patient and Provider Perspectives
Authors: Qudah Bonyan A. , Maurer Martha A. , Mott David A. , Chui Michelle A.
Published: July 2022

Providing patient-centered care to manage chronic pain and opioid use disorder (OUD) is associated with improved health outcomes. However, adopting a holistic approach to providing care is often challenging in rural communities. This study aims to identify and contrast challenges to providing patient-centered care from the perspective of patients and providers. A participatory design approach was adopted to elicit the perceptions of providers and patients with lived experiences of chronic pain and OUD in Jefferson County, Wisconsin. Two focus groups were conducted with each stakeholder group to identify problems that participants face with respect to chronic pain management and OUD and possible solutions. Four interviews were conducted with providers experienced in chronic pain management. Analysis of focus group sessions and interviews show consensus among patients and providers that lack of behavioral health and recovery resources create barriers to effectively manage OUD and chronic pain. However, there was discordance among the two groups about other barriers such as patient and provider attitudes, tapering approach, and access to medications for OUD. This tension among patients and providers can influence patients’ retention in therapy. More efforts are needed to mitigate stigma among providers in rural communities and support psychosocial needs of patients.
Symmetrical Simulation Scheme for Anomaly Detection in Autonomous Vehicles Based on LSTM Model
Authors: Alsulami Abdulaziz A. , Abu Al-Haija Qasem , Alqahtani Ali , Alsini Raed
Published: July 2022

Nowadays, technological advancement has transformed traditional vehicles into Au-tonomous Vehicles (A.V.s). In addition, in our daily lives, A.V.s play an important role since they are considered an essential component of smart cities. A.V. is an intelligent vehicle capable of main-taining safe driving by avoiding crashes caused by drivers. Unlike traditional vehicles, which are fully controlled and operated by humans, A.V.s collect information about the outside environment using sensors to ensure safe navigation. Furthermore, A.V.s reduce environmental impact because they usually use electricity to operate instead of fossil fuel, thus decreasing the greenhouse gasses. However, A.V.s could be threatened by cyberattacks, posing risks to human life. For example, re-searchers reported that Wi-Fi technology could be vulnerable to cyberattacks through Tesla and BMW AVs. Therefore, more research is needed to detect cyberattacks targeting the components of A.V.s to mitigate their negative consequences. This research will contribute to the security of A.V.s by detecting cyberattacks at the early stages. First, we inject False Data Injection (FDI) attacks into an A.V. simulation-based system developed by MathWorks. Inc. Second, we collect the dataset generated from the simulation model after integrating the cyberattack. Third, we implement an intelligent symmetrical anomaly detection method to identify FDI attacks targeting the control system of the A.V. through a compromised sensor. We use long short-term memory (LSTM) deep networks to detect FDI attacks in the early stage to ensure the stability of the operation of A.V.s. Our method classifies the collected dataset into two classifications: normal and anomaly data. The ex-perimental result shows that our proposed model's accuracy is 99.95%. To this end, the proposed model outperforms other state-of-the-art models in the same study area.
Posture Evaluation Based on Forward Kinematics and Inverse Kinematics of Parallel Link Type Machine Tool
Authors: Tanaka Hiroto ,   Kanazawa Institute of Technology 7-1 Ohgigaoka, Nonoichi, Ishikawa 921-8501, Japan, Morimoto Yoshitaka , Hayashi Akio , Yamaoka Hidetaka
Published: July 2022

Parallel mechanisms with multiple links have been expected to be used in machining because they are higher in rigidity, accuracy, and output power than series mechanisms, such as industrial robots. However, unlike conventional machine tools, which consist of linear and rotary axes, parallel mechanisms have a large number of error factors. In the parallel link mechanism, there is no guide surface that physically guarantees linearity, and all accuracy is determined by the operating performance of the composite axes. This makes it difficult to identify any error factors. Therefore, a kinematics model is devised, and the behavior of the tool tip is checked by inputting the encoder information during the actual operation of a specific axis. Based on the results, we evaluate the machining characteristics of the target machine tool. The target machine tool in this study is a 5-axis machine tool that combines a 3-DOF parallel mechanism consisting of three linear motion axes and a 2-DOF serial mechanism consisting of two rotary axes. In our previous research, we tried to build a forward kinematics model. Although its prediction accuracy was insufficient, it was possible to actually identify the cause of the defect in the quality of the machined surface using the servo position information of the kinematics machine. However, we have not been able to construct an inverse kinematics model that is suitable for calculating the correction position command value to improve the quality of the machined surface. In this study, based on the shape creation theory, we devise and evaluate the kinematics model of a robotic machine tool that has a parallel mechanism. As a result of comparing the kinematics model with the 3D-CAD model in order to evaluate the accuracy of the former, it was confirmed that the proposed method has high simulation accuracy. Then, machining tests were carried out to evaluate the machining accuracy by measuring, based on proposed kinematics model, the machined surfaces in order to identify the mechanism that affects the texture of the machined surface. In addition, we performed a circle interpolation to confirm the effects of reversing the motion of each drive axis on the behavior of the tool tip. As a result, it is considered that the linear motion axis has a large effect on the behavior of the tool tip on the quadrant glitch of each drive axis. It was also found that the effects of the 1st- and 3rd-axes on the behavior of the tool tip are different from those of the 2nd-axis.
Preliminary study for standardization of four to six years old questionnaires of Social Emotional Child monitoring system for young children: Korean Ages and Stages Questionnaires: Social-Emotional 2
Authors:   Korean Journal Of Early Childhood Special Education, Heo Kay-Heoung , Song Seo-Young , Lim Hee-Soo
Published: July 2022

The purpose of the study is to pursue a preliminary study for standardization of four to six years old questionnaires of social emotional child monitoring system, the Korean Ages and Stages Questionnaires: Social-Emotional 2. Data were collected and analyzed from 717 parents of young children aged 42 to 78 months in Seoul and Gyeonggi province. As a result of the study, first, the mean of the K-ASQ:SE 2 by questionnaires was 30.83 for 48 months and 23.12 for 60 months. The level of item fit was appropriate, and correlation between the total and individual item was positive signification. There was significant negative relationship with the SEAM and the revised K-ASQ, as the concurrent validity. Cutoff scores based on the 1.5SD, and 2SD was determined, and discriminate validity was confirmed based on these cutoffs. Second, as a result of reliability analysis, Cronbach alpha’s coefficient was found to be .819 for 48 months and .679 for 60 months. Interrater reliability between parents and teachers was 92.2% for 48 months and 80.0% for 60 months based on the 2SD cutoffs. In conclusion, possibility of standardization as establishing social emotional child monitoring system was predicted. Future study for standardization was proposed considering all age groups, regional arrangement, and developmental levels of young children.
Wissenschaft-Praxis-Kooperation in der spätmodernen Gesellschaft
Authors: Liegmann Anke Barbara , Breiwe René , Bau Jessica , Ervens Britta , Schwehr Marion , Racherbäumer Kathrin
Published: July 2022

Wissenschaft-Praxis-Kooperation in Form von Research Learning Communities (RLCs) gilt als probater Weg für erfolgreiche evidenzbasierte Schulentwicklungsprozesse (Rose et al. 2019). In diesem Sinne arbeiten im Projekt UDIN Wissenschaftler:innen, Lehrpersonen und Studierende an inklusiven digitalen Lernarrangements. In diesem Beitrag werden Strukturen und Praktiken dieser Kooperation in den Blick genommen, um Kommunikationsstrukturen kritisch zu beleuchten. Hierzu werden diese Praktiken in den Kontext der Charakteristik der spätmodernen Gesellschaft (Reckwitz 2017) gestellt und die Arbeitswelt der jeweiligen Bezugssysteme der kooperierenden Akteure (Schule, Wissenschaft, Studium) im Hinblick auf ihre Passung zu projektförmigem Arbeiten in Wissenschaft-Praxis-Kooperationen (in Form von RLCs) betrachtet. Anhand ausgewählter Rekonstruktionen (Dokumentarische Methode) der Gespräche aus den Treffen der RLCs zeigt sich, dass die Verhaftung im Allgemeinen aufseiten der schulischen Akteure dem Anspruch an Projektarbeit – das Besondere, Einzigartige herauszuheben – entgegensteht.
Lithofacies variability of the Yarakta horizon as a complex result of geodynamic processes of tectonogenesis and sedimentogenesis
Authors: Rapatskaya L. A. , Karpikov A. V.
Published: July 2022

The purpose of the research is to analyze the lithological and facies conditions of formation and the causes of lithological composition variability of the Yarakta horizon deposits as well as formation and distribution features of reservoir rocks in the horizon. The paper uses the data on drilling and geophysical work results and research materials from the public sources. The Yarakta horizon is commercially productive in the deposits of the southeastern slope and the central part of the Nepa-Botuoba anteclise: Dulisminskoe, Yaraktinskoe, Ayanskoe, Danilovskoe deposits, etc. The deposits of the Yarakta horizon were formed during the initial transgressive stage of the Vendian sedimentation cycle and are characterized by extreme lithological irregularity of rock composition and thickness. Investigations of a number of scientists testify that in the early formation of the Yarakta horizon its territory in geomorphological terms was predominantly presented by a coastal plain, which was occasionally flooded by the sea. The rocks in the area are represented by the facies of temporary proluvial-deluvial flows of the coastal plain replaced by coastal shallow sediments. The change in the lithological composition of rocks and thicknesses of the Yarakta horizon is a result of changes in the nature of oscillatory movements, while its structural and textural features are determined mainly by the dynamics of water flows of the sedimentation medium and the paleorelief nature of the underlying surface. The conducted research allows to conclude that lithological heterogeneity of the Yarakta horizon in sections (vertically) and along the strike (laterally) is determined by the frequent alternation of various lithotypes, the formation of which is determined by the complex nature of tectonic movements and irregularity features of sedimentary layer facies.
A multidimensional approach in examining the role of self-efficacy on innovative work behavior: Evidence from the creative industry
Authors: Musannip Efendi Siregar Zulkifli , Nur Supriadi Yudi , Setyo Pranowo Agus , Ende  , Jayanti Harahap Nova
Published: July 2022

Innovative work behavior is a significant factor for business success, including in the creative industry. This paper aims to explore the effect of self-efficacy on the innovative work behavior of employees in the creative industry sector. This study uses a quantitative research approach. It was conducted on small and medium enterprises in the creative industry sector in Labuhanbatu and South Labuhanbatu regencies, Indonesia. The participants in this study were employees and managers in the creative industry. The sampling technique is non-probability sampling. A total of 250 questionnaires were distributed, and 216 questionnaires were returned. Therefore, the samples in this study were 216 respondents. After the data were collected, they were processed by the Structural Equation Modeling (SEM) method, which uses a multidimensional approach to testing the hypothesis. The results revealed that innovative work behavior was influenced by self-efficacy. Based on the results of the multidimensional analysis, it was shown that the most influential dimension in measuring innovative work behavior was the idea champion. In addition, the strength dimension dominantly influenced self-efficacy as the most influential dimension. The originality/value of this paper is that the analysis using multidimensional analysis shows that self-efficacy can predict innovative work behavior. The SMEs in the creative industry are suggested to give support to enhance their capability to improve employee self-efficacy and innovative work behavior.
Da Parentalidade Sustentável: O Direito à Convivência Familiar como Realidade e Não Como Expectativa
Authors: Moraes Carlos Alexandre , Vieira Diego Fernandes
Published: July 2022

O trabalho tem por objetivo analisar o direito à convivência familiar e sua atual realidade em face das crianças e adolescentes, fundamentando-se em pesquisas científicas, legislação vigente e jurisprudência. Fomenta-se assim a discussão sobre o exercício da parentalidade com foco na prevenção e na proteção da população infantojuvenil, tendo em vista que os danos ocasionados pelos pais aos filhos só podem ser compensados e não reparados. Empregou-se para tanto o método hipotético-dedutivo conjuntamente com o método de investigação bibliográfico e o documental, sob o crivo de uma abordagem qualitativa. Chegou-se à conclusão de que a realidade em que se encontra o exercício da parentalidade é insustentável, que o direito à convivência familiar resta prejudicado e violado constantemente por práticas de abandono afetivo e de alienação parental, necessitando-se urgentemente de uma nova postura jurisdicional, voltada a uma parentalidade, além de responsável, sustentável.
Liberdade e Soluções Consensuais: Uma Via de Litigância Estratégica
Authors: Serva Clara Pacce Pinto , Piovesan Flavia
Published: July 2022

O trabalho analisa as soluções consensuais no âmbito das litigâncias estratégicas pelo prisma da liberdade de escolha da composição mais adequada ao caso concreto. Com base na análise exauriente de todos os Informes de Solução Amistosa emitidos pela Comissão Interamericana de Direitos Humanos, busca-se avaliar, à luz de Hobbes, o papel da liberdade das partes nos mecanismos autocompositivos como potencializador de transformação social em conflitos envolvendo Direitos Humanos, partindo-se da observação do ordenamento jurídico brasileiro e das soluções amistosas firmadas no âmbito da Comissão Interamericana de Direitos Humanos.
Carta editorial
Authors: Calabrese Claudio , Galindo Cruz Pablo
Published: July 2022

Carta editorial
The end of Liberalism?
Authors: Carlson Allan C. , Hurtado Domínguez Rafael
Published: July 2022

The article argues that the liberal family system, as crafted by late 17th Century British political theorist John Locke and enjoying apparent success as late as the 1960s, is now in ruins. Three internal contradictions which brought the system down can be identified: the first was a faulty understanding of human nature, which denigrated males and placed too great of the real family burden on women; the second contradiction was the liberal family’s lack of functions, which led to its material and economic disintegration; the third was its reliance on coercive social engineering, which undermined the very religious values which allowed the known system to work. “Self-actualization” and “gender theory,” Carlson and Hurtado show, are the logical consummation of liberalism, and fatal to its natural family order. They also reveal how and why the liberal ideal of tolerance has failed in recent decades.
Role of essential amino acid tryptophan in causing sleep disorders and anxiety-depressive disorders
Authors: Karnaukhov Vladislav E. , Narodova Ekaterina A. , Shnayder Natalya A. , Narodova Valeria V. , Dmitrenko Diana V. , Nasyrova Regina F.
Published: July 2022

Sleep is one of the most important and vital physiological processes in the human body. In addition to the length of daylight hours, the nature of work activity, bad habits (smoking, alcohol abuse, excessive consumption of caffeine-containing drinks, psychostimulants), the factors that violate the duration and quality of sleep include the nature and style of nutrition, as well as eating habits that affect daily intake vital nutrients (vitamins, essential amino acids, polyunsaturated fatty acids, etc.). Tryptophan is one of the essential amino acids associated with sleep disturbance. Given the high clinical significance of sleep disorders in the development of neurological diseases and mental disorders, the interest of researchers in the study of modifiable and non-modifiable risk factors for sleep disorders is growing. Objective: to analyze and systematize the results of fundamental and clinical studies of recent years on the role of tryptophan in the development of sleep disorders and anxiety-depressive disorders in adults. Materials and methods. This thematic review included available full-text publications obtained as a result of a literary search in the domestic (E-Library) and foreign databases (PubMed, Scopus, Oxford University Press, Springer, Web of Science Core Collection). Results. The role of tryptophan as a key link in the synthesis of melatonin and serotonin in the occurrence of sleep disorders and anxiety-depressive disorders is significant and can be used for further study. Conclusion. Based on the review of the literature, it can be concluded that one of the important mechanisms of sleep disturbance and the occurrence of anxiety and depressive disorders is insufficient intake of tryptophan in the body. This pattern is a consequence of the consumption of food with a low content of this essential amino acid. Considering the consequences that tryptophan depletion can lead to in the human body, competent nutritional support is a necessary measure.
Age-related changes in the area of the human corpus callosum
Authors: Balandin Anatolii A. , Yurushbaeva Guzel' S. , Balandina Irina A.
Published: July 2022

Objective: to carry out a comparative analysis of the area of the corpus callosum in men and women in adolescence, old age, and old age according to magnetic resonance imaging data. Material and methods. The results of magnetic resonance imaging studies of the brain of 138 patients (72 men and 66 women) were analyzed. The entire study material was divided into three groups. The first group included 44 adolescents (21 men and 23 women aged 16-21 years); the second group included 50 elderly people (27 men and 23 women aged 56-74 years); the third group included 44 seniors (24 men and 20 women aged 75-88 years). We determined the area of the corpus callosum in the sagittal projection along the midline. Results. The analysis of the results of the study revealed a tendency for the prevalence of cerebellar area parameters in boys and girls in comparison to the elderly and senile age representatives (p>0.05). There was a tendency for prevalence of cerebral body area parameters in elderly subjects over elderly ones (p>0.05). In all age groups there was a tendency for superiority of cerebral body area parameters in men compared to women (p>0.05). Conclusion. The obtained results of the in vivo comparative analysis of the area of the corpus callosum in humans in adolescence, old age and senile age extend the scientific knowledge of its age-specific features. Thus, these data can serve as a benchmark of age-related anatomical norm in various instrumental examinations, such as magnetic resonance imaging and computed tomography, and provide a foundation for further clinical research.
Peculiarities of macroand microelement accumulation in common yarrow herb of the Voronezh region
Authors: Dyakova Nina A.
Published: July 2022

Researches of elemental composition of wild-growing raw materials are actual and significant because of high efficiency and bioavailability of their metal-organic forms contained in plants. Available data on the content of elements in medicinal plant raw materials of the Voronezh region showed that studies are conducted mainly on a few elements, which does not allow to determine the full chemical composition of plants and to describe the specificity of accumulation of the whole complex of minerals in them. Objective. The aim of the investigation was to study the accumulation of macro- and microelements in common yarrow herb of natural phytocenosis of the Voronezh region. Materials and methods. Preparation of medicinal plant raw materials was carried out during the flowering of the plant in the Voronezh State Natural Biosphere Reserve. The microelement of medicinal plant raw materials was determined by mass spectroscopy with inductively coupled plasma on the ELAN-DRC device. Results. It was found that the content of microelement complex is 3.28%, 59 elements were determined. Macronutrients account for 93.78% of the total elemental composition of common yarrow herb. The basis of macronutrients is potassium (more than 14 mg/g), and calcium (more than 10 mg/g). Essential microelements make up 5.51% of the total mineral complex of the common yarrow herb. Among them the highest content was noted for silicon (more than 1.6 mg/g), iron (more than 0.1 mg/g). The content of the rationed heavy metals and arsenic in the herb common yarrow corresponds to the requirements of the normative documentation. The proportion of toxic and understudied elements in the total mineral complex of common yarrow herb is 0.71%. The highest content was noted for aluminum (116.5 µg/g), strontium (81.6 µg/g), titanium (12.5 µg/g), rubidium (9.5 µg/g), barium (9.31 µg/g). The high ability of common yarrow herb to accumulate phosphorus, potassium, copper, zinc, molybdenum, strontium from soil was shown. Conclusion. The data obtained are of great interest and can serve as a basis for further research with the aim of using their results in medical and pharmaceutical practice to create drugs and biologically active additives for correcting physiological norms of element content in the human body.
Natural Flavonoids in the Prevention and Treatment of Lung Cancer: A Pharmacological Aspect
Authors: Talukdar Anupam Das , Nath Rajat , Das Chandrima , Kityania Sibashish , Nath Deepa , Das Subrata , Choudhury Manabendra Dutta , Patra Jayanta Kumar
Published: July 2022

Deadly disease cancer has many types; among them, lung cancer is responsible for the highest number of cancer mortality. Existing therapies as well as drugs for treating lung cancer are not effective and are often associated with innumerable side effects and toxicities. For these reasons, researchers have been working on developing novel anti-cancer medicines from plants and other natural sources that have a high safety profile. Natural flavonoids are a polyphenolic group of phytochemicals extracted from plants and other plant-derived compounds. Natural flavonoids are gaining popularity due to their unique and priceless medicinal properties, including anticancer properties. Several researchers have already declared that flavonoids possess the ability to treat different cancers, particularly lung cancer. The bioactivity of natural flavonoids is mainly due to their structural diversity. Natural flavonoids fight against lung cancer by regulating redox homeostasis, upregulating apoptosis, pro-apoptotic factors, and survival genes, arresting cell cycle progression, autophagy, reducing cell proliferation and invasiveness, maintaining inflammation response, downregulating anti-apoptotic factors, and targeting lung cancer signaling pathways. Flavonoids can act alone or synergistically with other agents to treat lung cancer. Due to these reasons, it is possible to use natural flavonoids as pharmaceutical leads to prevent and treat lung cancer.
WITHDRAWN: Pharmaceutical Nanoemulsion System: A Strategy to Enhance the Bioavailability of Drugs
Authors: Kumar Shobhit , Waliyan Parul , Pahwa Rakesh , Ali Javed , Baboota Sanjula , Sharma Shrestha , Hyder Pottoo Faheem
Published: July 2022

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An Update on Recent Green Synthetic Approaches to Coumarins
Authors: Bhimani Bhargav , Patel Ashish , Shah Drashti
Published: July 2022

Coumarin and its derivatives are privileged heterocyclic motifs and important building
blocks for developing the biologically active compound due to its significant role in the development
of new drugs. As a result, many methodologies have been developed to synthesize this important
class of compounds. However, some methods are associated with toxic and corrosive catalysts, longer
reaction time, poor yield, less purity, and by-products along with the desired product. In order to minimize the utilization and generation of toxic organic substances, green synthetic methods are applied
in this manner. Green chemistry methods cover a wide range of methods, including the application of
ultrasound and microwaves, ionic liquids and deep eutectic solvents, solvent-free and catalyst-free
synthesis, and mechanosynthesis. These green synthetic methods have successfully performed all typical condensation reactions for coumarin synthesis like Knoevenagel, Perkin, Kostanecki-Robinson,
Pechmann, and Reformatsky reactions. Compared to conventional methods, these methods not only
minimize the use and generation of harmful chemicals but also improve reaction efficiency in terms
of product yields, purity, energy consumption, and post-synthetic procedures. Due to the implication
of coumarin (2-oxo-2H-1-benzopyran) backbone as a biologically active ubiquitous fragment and the
recent demands of reducing toxic solvents, catalysts, and energy consumption, this review summarized various green synthetic methods for coumarin synthesis. Moreover, researchers working on this
coumarin scaffold synthesis can find handy information from this review on the green synthetic approaches to their synthesis.
In vitro Investigation of the Effect of Anti-inflammatory and Analgesic
Drugs on Measurement of Tumor Markers
Authors: Gonel Ataman , Taskiran Huseyin
Published: July 2022

Background:

It has been shown that some drugs used as parenteral affect biochemical
measurements. Anti-inflammatory and analgesic drugs may also have the potential to affect measurement
methods.

Objective:

The aim of the study was to investigate the effects of seven different anti-inflammatory
and analgesic pharmacological agents commonly used in wards and intensive care units on thyroglobulin,
CA125, CA15-3, CA19-9, CEA, PSA and total HCG tests measured by immunoassay
technique.

Methods:

The study was performed using hormone control material (BioRad Lyphocheck Immunoassay
Plus Control) in the PETINIA immunoassay method (Siemens, Atellica, USA). 20 μL of
tenoxicam, dexamethasone, methylprednisolone, paracetamol, diclofenac sodium, dexketoprofen,
and metamizole sodium were added into 180 μL of the control solution, respectively. After vortexing
the sample, it was incubated for 20 minutes at room temperature. Thyroglobulin, CA125, CA15-
3, CA19-9, CEA, total PSA and total HCG tests were studied from the control sample. The study
was re-performed by adding 20 μL of distilled water. The measurements were repeated 3 times, and
the mean values were recorded. Percentage deviation rates from the target value were calculated.

Results:

Metamizole sodium led to negative interference in the CA 19-9, total HCG, CA 125, CEA,
total PSA and CA15-3 at a rate of -42.1%, -24.62%, -24.34%, -23.66%, -14.33%, and -13.91%,
respectively. With the administration of metamizole sodium, the only positive interference was
determined at a rate of 6.02% in thyroglobulin. Paracetamol-induced maximum deviation was calculated
at the rate of -26.41% in CA 19-9. CA 19-9 deviated -12.22% from diclofenac sodium and -
22.41% from dexketoprofen. With methylprednisolone administration, positive interference was
detected at a rate of 14.46% in thyroglobulin and negative interference at a rate of -12% in total
PSA. The highest deviation due to dexketoprofen was seen in CA 19-9 at a rate of -22.41%.

Conclusion:

This study demonstrated the potential of anti-inflammatory, analgesic, and antipyretic
agents to affect tumor marker measurements. Especially in the follow-up of cancer patients, antiinflammatory
interference may increase the likelihood of malpractice by causing erroneous clinical
evaluations.
Deep Learning-based Inverse Design of the Complete Photonic Band Gap
in Two-Dimensional Photonic Crystals
Authors: Hao Ran , Ma Bole , Yan Haotian , Jiang Huaqing , Chen Jianwei , Tang Kaida
Published: July 2022

Background:

With the continuous development of computer science, data-driven computing
methods have shown their advantages in various fields. In the field of photonics, deep learning
(DL) can be used to inversely design the structure of optical devices.

Objective:

The two-dimensional (2D) photonic crystal (PCs) with adjustable structural parameters
and a large complete photonic band gap (CPBG) are inversely designed in terms of DL neural network
(NN) tagged to obtain a specified width of CPBG.

Methods:

The new PCs structure is designed by combining multiple factors that produce a CPBG.
Tandem networks are used to speed up the training of the NN and tackle the problem of nonuniqueness
that arises in inverse design.

Results:

After various attempts and improvements, the ideal PCs structure was obtained. It is found
that the connecting channel between the primitives in the PCs unit cell has a dominate effect on the
CPBG. The use of a tandem network enables better convergence of the network. Finally, suitable
NN can be obtained, which can realize the forward prediction of the CPBG and the inverse design
of the structure.

Conclusion:

DL can realize forward prediction and inverse design of 2D PCs targeting the width
of the CPBG, which broadens the application scope of DL in the field of PCs.
Role of Extracellular Vesicles in Stem Cell Therapy
Authors: Kaiser Michael , Rodriguez-Menocal Luis , Badiavas Evangelos V.
Published: July 2022

Burn wounds are a major source of morbidity and mortality in both the military and civilian
settings. Research about the pathophysiology of thermal injury has revealed possible interventions
that can aid this process to reduce scarring and wound contracture. Bone Marrow derived Mesenchymal
Stem Cells (BM-MSCs) have been an exciting topic in research for many years. They have
been shown to facilitate wound healing and tissue regeneration, two areas that are vital in the healing
process, especially in burn wounds. More recently the discovery of Extracellular Vesicles (EVs) has
allowed us to further characterize the immunomodulatory roles and understand the cellular pathways
implicated in wound healing. The purpose of this review is to discuss the role of EVs in wound healing,
and to propose that EVs are the main mechanism that deliver cellular materials to target cells to
coordinate wound healing following tissue injury.
Molecular Identification of Free-living Amoebae Isolated from Hospital
Water Systems in Southwest Iran
Authors: Salehi Azin , Arjmand Reza , Beiromvand Molouk , Tavalla Mehdi
Published: July 2022

Introduction:

Free-living amoebae are opportunistic amoebae that usually live freely in
various environmental conditions, including warm water and even in water supply network pipes and
reservoirs connected to water. In addition to living freely, these protozoa are able to attack the host's
body when they enter a human or animal body. Therefore, it is necessary to identify their presence in
water resources. So, this study aimed to identify free-living amoebae isolated from water reservoirs of
hospitals in southwest Iran.

Methods:

A total of 80 water samples were isolated from the hospitals of Ahvaz city, southwest Iran,
and their physical and chemical parameters were measured. The samples were then put into non-food
agar culture medium and stained using the Wright-Giemsa staining. Finally, the samples were identified
by the PCR molecular method.

Results:

The mean pH and turbidity values were 7.57 ± 0.03 and 3.31 ± 0.26 nephelometric turbidity
unit (NTU), respectively. The mean residual chlorine and electrical conductivity were 0.91 ± 0.02 and
1122.39 ± 24.31, respectively. In addition, 9 (11.25%) and 3 (3.75%) samples were contaminated with
Acanthamoeba spp. and Naegleria spp., respectively. However, no positive cases of Balamuthia spp.
infection were observed. Moreover, two samples were co-infected with Acanthamoeba spp. and
Naegleria spp.

Conclusion:

Due to the existence of free-living amoebae in water storage tanks at hospitals, it is necessary
to prevent possible contamination with these amoebae and infectious agents by using new methods
of disinfection and purification of water resources.