bluuebunny/crossref_metadata_2025 huggingface dataset:
Immunomodulatory, anti-infammatory and antioxidant activities of aqueous and ethanolic extracts of Cissus quadrangularis Linn. (Vitaceae) in chronic pain
Authors: Feigni Olga Youyi Marcelle , Mbiantcha Marius , Yousseu William Nana , Tsafack Gonzal Eric , Djuichou Flore Nguepnang Stephanie , Noungoua Chrétien Mbeugangkeng , Atsafack Gisèle Mboudem Lylie , Ateufack Gilbert
Published: November 2022

Cissus quadrangularis Linn. (Vitaceae) is a plant used to treat injured tendons, broken bones, asthma, stomach ache, scurvy and digestive disorders. The present study purposed to evaluate the antihyperalgesic effects (in vivo) and the immunomodulatory, antioxidant and anti-inflammatory properties (in vitro) of aqueous and ethanolic extracts of Cissus quadrangularis (C. quadrangularis). Immunomodulatory (chemiluminescence, cytokines and cell proliferation), anti-inflammatory (protein denaturation, 5-lipoxygenase, cyclooxygenase 1 and 2) and antioxidant (DPPH, ABTS and NO) tests were performed in vitro, while the anti- hyperalgesic (vincristine) investigations were conducted in vivo on Wistar rats. The results revealed that extracts developed immunomodulatory activity by inhibiting the production of ROS (intracellular/extracellular), of TNFα, IL-1β, IL-6 as well as inhibiting cell proliferation, and by stimulating the production of IL-10. The anti-inflammatory activity of the extracts was demonstrated by an inhibition of 5-LOX, protein denaturation and cyclooxygenases 1 and 2. In addition, extracts showed interesting scavenging effects, attesting their antioxidant potential. The extracts administered to the animals (180 and 360 mg/kg) inhibited (p < 0.001) hyperalgesia and allodynia in animals. These extracts also led to the reduction in serum and sciatic nerve levels of TNFα, IL-1β and IL-6, as well as to an increase in cell growth factors (NGF and IGF) production of treated animals. These results suggest that extracts of C. quadrangularis use immunomodulatory, anti-infammatory and antioxidant capacity to prevent and/cure painful neuropathy after vincristine administration. C. quadrangularis is therefore a promising natural substance for the management of neuropathic pain.
Atomic-level Chemical Reaction Promoting External Quantum Efficiency of Organic Photodetector Exceeding 10^8% for Weak-Light Detection
Authors: Shi Linlin , Zhu Yizhi , Guohui Li , Ji Ting , Wang Wenyan , Zhang Ye , Wu Yukun , Hao Yuying , Wang Kaiying , Zhang Fujun , Yuan Jun , zou yingping , Ong Beng , Zhu Furong , Cui Yanxia
Published: November 2022

Low-cost, solution-processed photomultiplication organic photodetectors (PM-OPDs) with external quantum efficiency (EQE) above unity have attracted enormous attention. However, their weak-light detection is unpleasant because the anode Ohmic contact causes exacerbation in dark current. Here, we introduce atomic-level chemical reaction in PM-OPDs which can simultaneously suppress dark current and increase EQE via depositing a 0.8 nm thick Al2O3 by atomic layer deposition. Suppression in dark current mainly originates from the built-in anode Schottky junction as a result of work function decrease of hole-transporting layer of which the chemical groups can react chemically with the bottom surface of Al2O3 layer at the atomic-level. Such strategy of suppressing dark current is not adverse to charge injection under illumination; instead, responsivity enhancement is realized because charge injection can shift from cathode to anode, of which the neighborhood possesses increased photogenerated carriers. Consequently, weak-light detection limit of the Al2O3 treated PM-OPD reaches a remarkable level of 2.5 nW/cm2, while that of the control is 25 times inferior. Meanwhile, the PM-OPD yields a record high EQE and responsivity of 4.31×108% and 1.85×106 A/W, respectively, outperforming all other polymer-based PM-OPDs.
Real-time Implementation and Experimental Verification of Dual-Switch Coupled Inductor (DSCI) Converter based BLDC Drive for Electric Vehicle Applications
Authors: Chandran Praveenkumar , Mylsamy Kaliamoorthy , Umapathy Prabha S
Published: November 2022

Large heat output and burning have recently emerged as critical challenges in electric vehicles (EV). The main causes of this issue are the use of spark-propelled motors and in-built complicated circuits. This research attempts to address the aforementioned issues by providing a reduced switch converter for Brush-Less DC (BLDC) motors. A Dual-Switch Coupled Inductor (DSCI) converter is proposed based on the BLDC drive for electric vehicle (EV) applications. Because the DSCI converter has only two switches, the need for a gate-driven circuit is greatly minimized, which is responsible for high heat dissipation and complicates the circuit. Theoretical analysis is performed on the operating principles, switching frequencies, component design concerns, maximum voltage gain, and efficiency, as well as simulations using Matlab® Simulink. The efficiency of the DSCI converter obtained is 98.23%. The converter is used to drive a 0.75-kW BLDC motor, and the simulation results are validated with a hardware prototype model at 3000 rpm. At the end of the paper, the explored results for both hardware and simulation and comparative studies with earlier work are described in detail.
Copper(II) coordination polymer based on L-arginine as a supramolecular hybrid inorganic-organic material - synthesis, structural, spectroscopic and magnetic properties
Authors: Musioł Karol , Janczak Jan , Helios Katarzyna , Witwicki Maciej , Fitta Magdalena , Pełka Robert , Wojciechowska Agnieszka
Published: November 2022

We report the synthesis and structural, spectroscopic and magnetic properties of new 1D coordination polymeric complex of the formulae {[Cu(µ−l−Arg)2]SO4⋅1.5H2O}n (1) that contains asymmetric µ − O,O’ carboxylic bridge linking distorted square-pyramidal [Cu(µ−l−Arg)2]2+ coordination units. In 1D the syn − anti − µ2 − η1:η1 zig-zag polymer conformation, the adjacent Cu(II) ions are distanced by 5.707 Å, and the subsequent Cu∙∙∙Cu proximity in 1D− coordination chain equals 6.978 Å. Detailed interpretation of IR and Raman spectra of l−arginine and 1 has been performed. The values of EPR parameters (gx=2.059, gy=2.075, gz=2.228) indicate nearly of axial local symmetry of Cu(II) coordination sphere (elongated square pyramidal geometry) and correspond to dx2−y2 orbital of unpaired electron ground state. The single broad band at 16200 cm–1, characteristic for d − d transition, is assigned to the dominant dublet-dublet 2B1g(dx2−y2)→2Eg(dyz≈dxz) transition. Magnetic susceptibility measurement has revealed ferromagnetic coupling between the Cu(II) ions within the 1D−coordination chain, while the intermolecular coupling is antiferromagnetic.
Genetic structure and variation of Liobagrus nigricauda of the upper Yangtze River basin based on cytochrome b
Authors: Jia Xiang-Yang , Li Wei , Tu Bin
Published: November 2022

Liobagrus nigricauda is endemic to the upper Yangtze River basin. By using the fast isolation by amplified fragment polymorphism of sequences containing cytochrome b, we identified the genetic variation in 6 populations of L. nigricauda. A total 21 nucleotide sites were detected in 1086 bp from cytochrome b, and 16 haplotypes were defined from 145 sequences. Nucleotide diversity index was 0.00087, and haplotype diversity index was 0.26858. Hierarchical analysis of molecular variance (AMOVA) showed that the variation from within populations was 93.03%. And the mainstream populations of the upper Yangtze River had preliminary genetic differentiation with tributary.
Exploring perception of rural women's towards cervical cancer and its screening in Sadi Chanka district, West Ethiopia: A qualitative study.
Authors: Shambi Dame Banti , Nigussie Tadesse , Lagasse Elsabeth , Guye Ararso Hordofa , Dureso Negasa Shuma , Jebesa Gemechis
Published: November 2022

Background: Cervical cancer is the fourth common cancer affecting women's reproductive oegans and challenges faced by women in worldwide. Cervical cancer screening is a public health intervention used on a population at risk, or target population to diagnose a disease. Effective screening programs reduce morbidity and mortality associated with this cancer. Objective: To explore perceptions of rural women's towards cervical cancer and its screening among women in Sadi Chanka district, Oromia, west Ethiopia.
Methods: A qualitative study was conducted using in-depth interviews to explore perceptions of rural women's towards cervical cancer and its screening among women in Sadi Chanka district, west Ethiopia from May 1 to May 30, 2022. A qualitative study design was employed and the study participants were acquired using heterogeneous purposive sampling techniques. In total, 9 interviews were conducted using in-depth interviews and key informant interview methods. The data were analyzed using thematic analysis manually. Thematic analysis were performed in order to extract the main themes, categories and codes. Direct quotations were presented with a thick description of the findings.
Results: A total of nine participants participated in in-depth interviews. The findings of this study were discussed under three themes and 7 categories which emerged from thematic analysis of the data. Awareness of cervical cancer and its screening, awareness of the risk factors, and syptoms of cervical cancer, Availability, accessibility and affordability of the service, gender prefer for screening and prevention and treatment of cervical cancer perception.
Conclusion: This study indicates that rural women's in the study area had low perceived about cervical cancer and its screening, health service related factors and perception of women's on prevention and treatment of cervical cancer were the key reasons for rural women's not cervical cancer screening. To improve cervical cancer and its screening, effort should be focused on enhancing positive perception of rural women's.
Implementation of Optimal Oil Flushing Methodology for Nuclear Steam Turbo Generator Oil circuits - A Case Study
Authors: Swamynathan Kudiyarasan , Lakshmanaraj Levankumar , Ramalingam Mahesh
Published: November 2022

The objectives of this article are to elaborate the various tactics used in flushing of Prototype Fast Breeder Reactor (PFBR) 500 MWe TG oil systems, the difficulties faced while doing flushing and lessons to be remembered before starting the oil flushing of TG oil systems. TG oil circuits flushing was carried out with Turbinol 46 in three stages. Oil samples were also collected periodically to monitor the flushing performance. In this article a simple method was used to find the minimum oil required for starting the flushing and make up requirements of oil during different stages of flushing. An energy balance approach was also used to find the fraction of oil going through cooler and cooler bypass line during thermal shocking process. This study reveals that it will be possible to control the cooling time of lube oil during stage-2 flushing which leads to an increase in number of thermal shocks per day thereby flushing time can be considerably reduced.
Improving energy efficiency and CO2 emissions reduction in the telecom sector: from exploration to development of framework for material flow costing
Authors: Kukreti Kamlesh , Ganguly Kunal
Published: November 2022

Telecommunication provides the infrastructure to deliver core services but contributes to extensive CO2 emissions. This study aims to demonstrate the effectiveness of Material Flow Cost Accounting (MFCA) in reducing carbon emissions in the telecom sector through energy optimization and improving operational efficiency by using electricity consumption as raw material and quantifying energy waste. An extensive literature review is conducted to identify the critical energy conservation initiatives in the telecom sector, followed by a questionnaire survey among Indian telecom managers to rate the identified initiatives. Finally, the outcome of the factor analysis was used as input for the successful implementation of MFCA in one of the large telecom industries in India. The study demonstrates a successful case of MFCA implementation with some promising results. The present case study may help promote the implementation of MFCA in sectors where material quantification of intangible products makes the identification of waste a hurdle for MFCA adoption.
The Use of Edge Cloud Computing Technology in Innovative Design of Historical Cultural and Creative Products in the Context of Augmented Reality
Authors: Li¹ Ren , Zhang² Bingyu
Published: November 2022

The purpose is to reconstruct the existing cultural form and change the traditional design concept of the historical cultural and creative product (CCP). In the context of Augmented Reality (AR), this exploration uses the edge cloud computing platform to calculate and process the brain-computer interface technology data, and makes a more in-depth discussion on the immersion, presence, and empathy effects of AR historical CCP. The brain-computer interface device is adopted to collect the different mental states of the subjects when viewing historical CCP in different media, and to conduct edge cloud computing analysis. The overall structure of the system is designed and developed, and some key technology implementation methods in the whole working process are analyzed, including the design of the visual interface, the implementation of the communication interface and the introduction and control of the robot. The results show that the designed AR fusion brain-computer technology system is efficient and stable. Meanwhile, it combines AR and steady-state visual evoked potential to provide a high-performance brain-computer interaction mode, which provides a reference value for developing AR fusion brain-computer technology system. Technological progress is not achieved overnight. In the near future, AR historical CCP should continue to focus on content, continuously improve technological innovation, and strive to bring a more shocking visual feast to the public. This exploration can enable the future AR technology to continue to overcome various problems, better serve the historical cultural and creative industry, build a new platform and drive cultural innovation to a higher and better direction.
Use of mobile phone sensing data to estimate residence and mobility times in urban patches during the COVID-19 epidemic: The case of the 2020 outbreak in Hermosillo, Mexico
Authors: Ramírez-Ramírez L. Leticia , Montoya José A. , Espinoza Jesús F. , Mehta Chahak , Akuno Albert Orwa , Bui-Thanh Tan
Published: November 2022

It is often necessary to introduce the main characteristics of population mobility dynamics to model critical social phenomena such as the economy, violence, transmission of information, or infectious diseases. In this work, we focus on modeling and inferring urban population mobility using the geospatial data of its inhabitants. The objective is to estimate mobility and times inhabitants spend in the areas of interest, such as zip codes and census geographical areas. The proposed method uses the Brownian bridge model for animal movement in ecology. We illustrate its possible applications using mobile phone GPS data in 2020 from the city of Hermosillo, Sonora, in Mexico. We incorporate the estimated residence-mobility matrix into a multi-patch compartmental SEIR model to assess the effect of mobility changes due to governmental interventions.
Sea-level rise and coastal flooding: A review of models for coastal policy and management
Authors: DEGUENON Sèna Donalde Dolorès Marguerite , Adade Richard , TEKA Oscar , Aheto Denis Worlanyo , SINSIN Brice
Published: November 2022

In the face of current uncertainties about the processes of climate change and its consequences, the search for possible response strategies is urgently needed. One of the most serious repercussions of climate change, which threatens many coastal areas globally, is the sea-level rise (SLR). To deepen understanding of this phenomenon and its related impacts, several models have recently been developed to satisfy the unique needs of coastal zone management. These models are very useful because of their visualization and prediction capabilities as they aid in decision-making regarding the adaptation of current protected area investments. This review, therefore, provides evidence of the potential and effectiveness of recent mapping models for managing the effects of sea-level rise. This study examined current models for mapping flood risk areas as a result of sea-level rise. It also provides guidelines to help coastal zone managers and policymakers decide the applicability of various models at local, regional, and global scales. There is no universally approved model, and each of the models examined in this article has its own set of advantages and limitations. However, relevant resources from the National Oceanic and Atmospheric Administration are more frequently utilized for organizations and beyond, and they are easier to understand and relate with by scientists and those with less scientific knowledge on sea-level rise.
Entrepreneurship Growth and Employment Generation for Regional Development in India through Foreign Direct Investments: An Empirical Analysis
Authors: Singha Seema , Choudhary Soma Roy Dey
Published: November 2022

This paper investigates the relationship between foreign direct investment (FDI) and employment opportunities in India. To investigate, they used coefficients of forward and backward linkages between foreign affiliates and local firms are also included to critically examine the impact of FDI on employment generation in India. Data for the present study was derived from the website of DIPP, MSME annual report, CSO, India and Economic survey report (2020-21) from the period 2006-2017 (due to unavailability of data). The empirical result shows that neither FDI create backward linkages with local firms nor foreign affiliates that have evidence of employment generation in the MSME sector in India. FDI creates only forward linkages with local firms to outsource or distribute their products to end consumers, the “market-seeking” motive of FDI. This study will help policymakers and government understand domestic firms' lacuna, FDI policy, and the channelization of foreign investment in manufacturing.
Does Foreign Direct Investment Leads to Growth of Micro, Small & Medium Enterprises in India: An Empirical Analysis
Authors: Singha Seema , Choudhary Soma Roy Dey
Published: November 2022

This study investigates the Spillover effects of inward foreign direct investments (FDI) and the probable absorption capacity of local firms (micro, small & medium enterprises) in India. To investigate the Spillover effects, we estimated the coefficients of the intersectoral linkages (backward & forward linkages) developed in economy and their respective performance in gross domestic production. Linear panel data model (fixed effects & random effects model), panel corrected standard error model and the Hausman Taylor instrument variable model employed to estimate the significant relationship between the variables. PCSE model provide robust standard error and control the problem of heteroskedasticity & autocorrelation, and Hausman Taylor model applied to deal with unobserved heterogeneity and check the robustness of the estimation of linear panel model. For the present study data collected for 27 industries of the economy (both manufacturing and service) from the year 2006-2017, since limited data are available for the study. Data collected from the MSME annual report, inputoutput & supply-use table from CSO, India, DIPP report for FDI data. The result indicates the negative relationship between inward FDI and gross domestic production of MSME sector, and forward linkages in economy significantly added to the GDP of the economy, indicating negative Spillover impact in upstream sector & positive Spillover in downstream sectors.
NATIONAL PROJECTS IN RUSSIA: PROBLEMS AND SOLUTIONS
Authors:   Transbaikal State University, Chita, Gorodkova S. , Makarova M. ,   Transbaikal State University, Chita, Malyshev E. ,   Transbaikal State University, Chita
Published: November 2022

Russia's national projects are an important tool for the socio-economic development of the state, which includes all sectors of the country's economy. The purpose of the national projects’ implementation is to improve economic performance, as well as to improve the well-being of the country's citizens. Over the past years, national projects have shown their effectiveness. Hospitals, schools, kindergartens have been built; a wide segment of the population has an opportunity to purchase housing on a mortgage. The development of agriculture is equally important; roads have been built and repaired, thereby raising the standard of living of the population. However, in the course of the national projects’ implementation, there are not only positive aspects, but also negative ones. The object of the study is the priority national projects of Russia. The subject of the study is the implementation of priority national projects in Russia and the Transbaikal Territory. The purpose of the study is to identify problems in the national projects’ implementation both in Russia and in the Transbaikal Territory. In carrying out the study, the following scientific methods have been used: economic method, statistical and comparative analysis, generalization and system analysis methods, monographic method. The information base for the event has become the data of Rosstat, the Accounts Chamber of the Russian Federation and publications on the Internet. In the course of the study, given the ambiguous approach to the definition of "national project", the concept is clarified. In addition, the formation chronology of the national project as a form of government is given. Problems in the implementation of national projects in Russia are identified, including the absence in most cases of an integrated approach to project activities, the need to bring the regulatory framework in line with modern requirements and realities, and overestimated indicators of national projects. An analysis of the national project’s implementation "Safe High-Quality Roads" in the Transbaikal Territory has been made, which noted problems in terms of insufficient provision of municipalities with funds for co-financing, problems with unscrupulous contractors, as well as problems with long overhaul periods. Based on the results of the results obtained, the authors have grouped the identified problems and proposed possible solutions, such as improving the legislative framework, working with contractors, and working out shortcomings when launching projects
THE IRANIAN MODEL OF THE RESILIECY ECONOMY: LESSONS AND RECOMMENDATIONS FOR RUSSIA
Authors:   University of Tehran, Tehran, Ehsan Rasoulinezhad  , Fatemeh Motamedi Sedeh  ,   University of Tehran, Tehran
Published: November 2022

The term of the resistance economy has been one of the most important topics of interest in Iran over the past decade, which is addressed as the main strategy of Iran to neutralize the negative consequences of the imposed sanctions by the West. The purpose of this research is to investigate the concept of resistance economy in the economic literature of Iran and Russia, to investigate the policies of the resistance economy of these two countries against economic sanctions. Also, in this article, the examined similarities and differences of the concept of resistance economy in two countries are described. The main conclusions highlight the positive impact of this strategy in order to mitigate the negative consequences of the financial and economic sanctions imposed by the western block. However, Iran and Russia should pay more attention to the advantages of multilateralism and regionalism in economic intreactions beyond the western sanctions
PROBLEMS AND PROSPECTS OF HIGHER EDUCATION EXPORT IN A CROSS-BORDER REGION (BY THE CASE OF THE TRANSBAIKAL STATE UNIVERSITY)
Authors:   Transbaikal State University, Chita, Kazantseva N. , Kazariyan I. ,   Transbaikal State University, Chita
Published: November 2022

Today strategic academic activity is more and more associated with the export of knowledge and services. One of the most topical directions in the development of the higher education system is connected with the increase of the academic export potential. In this context, the trends and challenges related to the export of educational services that the present-day system of higher education faces require systematic understanding, interpretation and objectively increase the need to consider and study the prospects for more effective involvement of universities of cross-border regions into the global market of educational services. The object of the research is higher education export. The subject of the research is the problems and prospects of the export potential development in the Transbaikal State University. The objective of the research is to assess the degree of involvement of the Transbaikal State University, as the leading university in the cross-border region, in export of educational activities, to identify the main problems and to determine the prospects for more effective work of the university in this direction. The objective of the research is achieved through the solution of the following tasks: to reveal the meaning of the concept of «higher education export», to conduct a comprehensive analysis of the theoretical works on this issue, to study international activities and the practice of providing educational services to foreign students by the case of the Transbaikal State University. The research methodology of the study is based on the works of Russian and foreign scientists devoted to this issue. To analyze the effectiveness of the Transbaikal State University’s work in this direction, the author used a factor analysis that is connected with the impact of external and internal factors, objective and subjective reasons that affect the effectiveness of the export educational activities of the leading university in the cross-border Transbaikal region. To create the methodological integrity of the study, universal methods of analysis, synthesis, and generalization were used
Methodological provisions for assessing the competitiveness of water transport companies
Authors:   St. Petersburg State Marine Technical University, St. Petersburg, Voronova D. , Marchenko S. ,   St. Petersburg State Marine Technical University, St. Petersburg
Published: November 2022

The authors have explored a number of scientific papers that consider the most common methods for assessing the competitiveness of enterprises, as a result of which their inherent shortcomings are established. The object of the study is the competitiveness of water transport companies. The subject of the study is the assessment of enterprises’ competitiveness. The purpose of the study is to consider the issues of assessing the companies’ competitiveness and to develop methodological provisions for determining the competitiveness of water transport companies. The methods of the study are presented by general scientific methods of system analysis and synthesis; methods of expert evaluations were used. When assessing the level of competitiveness of water transport companies, in particular seaports, a modified method based on the theory of effective competition and allowing the most complete consideration of various aspects and aspects of the company's production activities is proposed to use. An algorithm for calculating the integral indicator of competitiveness has been developed. Using the proposed algorithm, a quantitative assessment of the level of competitiveness of the logistics company JSC "Sea Port of St. Petersburg" in relation to one of its main competitors - JSC "Petrolesport" has been carried out, as a result of which its advantage in this indicator was established. As a result – an algorithm for calculating the integral indicator of the company's competitiveness level has been formed
ЗНАНИЕ, ПОЛУЧЕННОЕ ВО СНЕ…К ВОПРОСУ ОБ ИНТЕРПРЕТАЦИИ«ТРАГЕДИИ ЧЕЛОВЕКА» ИМРЕ МАДАЧА
Authors: М.С. Петрова
Published: November 2022

В настоящей статье сочинение Имре Мадача (1823–1864) «Трагедия человека» анализируется в ракурсе идеализма, поиска чувственности и рационализма. Показывается, каким образом Адам, главный герой «Трагедии», пребывая в состоянии сна, эмоционально и интеллектуально созревает, получает жизненный опыт, как возникают и обесцениваются его жизненные идеалы. Выявляется, как цветистое в языковом отношении рассуждение И. Мадача о трагедии человека, генерируясь, выстраивается и варьирует между такими составляющими, как поиск идеала, негативизм, эмоциональность и чувственность, стремление к познанию, выливаясь в мощный синтез в финальной сцене.

In this paper “The Tragedy of Man” by Imre Madách (1823–1864) is analyzed from the point of his search for idealism, sensuality and rationalism. It is demonstrated how Adam, the protagonist of “The Tragedy”, being in a state of sleep, emotionally and intellectually matures, gets life experience, how his life ideals arise and depreciate. It is shown how Madách’s flamboyant story in which the tragedy of man unfolds, is arranged, varying between idealism, negativism, emotionality, aspiration to cognition, resulting in a powerful synthesis in the final scene.
МЕДИЦИНА СССР И КИТАЯВ 1950-Е ГОДЫТРАДИЦИИ И ИНТЕГРАЦИЯ ПРАКТИК
Authors: О.С. Нагорных
Published: November 2022

Статья посвящена научно-историческому анализу потенциала китайской традиционной медицины, сохранившей в середине XX века большое значение для поддержания здоровья китайского населения. В ней не только привлекается внимание к проблеме трансформации медицинских традиций СССР и Китая в 1950-х гг. как интеграции практик, но и отмечается, что советско-китайское сотрудничество в сфере медицины в указанный период предполагало взаимный обмен достижениями. Через переосмысление отношения к значению традиционных методов китайской медицины автором определяются точки пересечения и возможности взаимодействия традиций и советских новаций в системе здравоохранения в Китае 1950-х гг., а также выявляются апробации методов китайской медицины в практике советских врачей.

The article proposes with the academic and historical evaluation of potential of Traditional Chinese Medicine which managed to keep its importance in health support of the population of China in the middle of the twentieth century. The problem of the USSR and China’s medical traditions’ transformation as an  integration of practices in the 1950s as a period of an integration of practices, while pointing out that the Soviet-Chinese medical cooperation at that time was meant to exchange their achievements. By rethinking the importance traditional methods of Chinese medicine, the author defines the points of contact and cooperation between Chinese traditional medicine and Soviet medical novations in Chinese health care system in 1950s. She also explores the instances of practical approbation of Chinese medicine methods in the practice of Soviet medics.
МАТЕРИАЛЫДЛЯ ПОЛНОЙ БИБЛИОГРАФИИ Д.С. МЕРЕЖКОВСКОГО
Authors: В.Л. Семигин
Published: November 2022

В работе дается перечень книг и брошюр Д.С. Мережковского, изданных на русском языке с 1888 по 1939 г. Раскрывается содержание сборников стихотворений, статей, новелл, собраний сочинений.

The article describes books and brochures by D.S. Merezhkovsky, published in Russian from 1888 to 1939. It covers the contents of collections of poems, articles, short stories, and collected works.
CASSIODORUS AND AUGUSTINE ON THE SOUL: GENERAL AND PARTICULAR
Authors: Петров Ф.В.
Published: November 2022

В статье обсуждаются представления Кассиодора (487–575) об индивидуальной душе и зависимость его психологических представлений от Августина (354–430) и других ранних авторов.

The paper discusses the ideas of Cassiodorus (487-575) on the individual soul and the dependence of his psychological ideas on Augustine (354-430) and other early authors.
Features of the composition of the intestinal microbiota in patients with colorectal cancer
Authors: Volkov S. V. , Lobanov S. L. , Dobrodeev A. Yu.
Published: November 2022

Purpose of the study: to investigate the composition of the intestinal microbiota and determine the feasibility of using it in diagnosis and prognosis of colorectal cancer (CRC). Material and methods. The study included 75 patients with CC (study group I) and 25 healthy individuals (control group II) who were treated at Chita State Medical Academy from 2017 to 2021. Group I patients underwent surgery and adjuvant chemotherapy. To determine the composition of the intestinal microbiota, biopsy specimens were taken from the tumor tissue and from the visually unchanged colon mucosa after the completion of surgery in the study group and from the visually unchanged colon mucosa during colonoscopy in the control group. Results. The counts of Bifidobacterium spp., E. Coli (typical) in the intestinal microbiota were significantly lower and the concentration of Clostridium spp. Was higher in CRC patients than in healthy individuals. Significant relationships between the counts of Lactobacillus spp., Bifidobacterium spp., Bacteroides spp., E. Coli and the patient’s gender; Lactobacillus spp., Bifidobacterium spp., Staphylococcus spp. (CNS) and the tumor grade; conditionally pathogenic microflora and the form of tumor growth were found. Some combinations of the composition of the intestinal microbiota in CRC patients are predictive factors for the development of postoperative complications (Lactobacillus spp., Bacteroides spp., E. Coli <3.0 CFU/g) and 3-year survival (Lactobacillus spp., Bifidobacterium spp., Bacteroides and E. Coli ≥3.0 CFU/g). Conclusion. The study of the intestinal microbiota makes it possible to differentiate patients with CRC, as well as to predict the risk of postoperative complications and patient survival.
Nivolumab monotherapy in metastatic colorectal cancer: current approaches to response evaluation
Authors: Babyshkina N. N. , Dronova T. A. , Gervas P. A. , Popova N. O. , Dobrodeev A. Yu. , Kostromitsky D. N. , Afanasyev S. G. , Goldberg V. E. , Cherdyntseva N. V.
Published: November 2022

Aim of the study: a systematic analysis of the modern literature data on the nivolumab monotherapy efficacy in patients with metastatic colorectal cancer (mCRC). Material and methods. The review summarizes the results of clinical studies of the nivolumab efficacy in patients with mCRC between 2012 and 2022. The current approaches to assessing the tumor response in patients treated with immune checkpoint inhibitors are considered, including response patterns and criteria. Results. Data analysis showed that the use of nivolumab in mCRC patients had significant clinical benefits. Nivolumab monotherapy was shown to improve survival in patients with high microsatellite instability (MSI) or deficiencies in mismatch repair (dMMR) that progressed during standard chemotherapy. Numerous clinical studies indicate the atypical response to nivolumab. Traditional response criteria, such as RECIST do not always adequately assess the therapeutic efficacy of nivolumab in patients with mCRC. Conclusion. To improve the efficacy of mCRC treatment, standardized approaches based on the proposed specific criteria for response to immunotherapy, including immune related RECIST, immune RECIST, and immune-modified RECIST must be developed.
Cancer incidence and mortality and state of cancer care for colorectal cancer patients in the Russian Far East.
Authors: Gordienko V. P. , Ilyushenok A. S.
Published: November 2022

The aim of the study was to estimate the incidence and mortality rates in patients with colorectal cancer in the Russian Far east in the time period from 2008 to 2020. Material and methods. Cancer incidence and mortality data collected from population-based cancer registries were used. Results. In 2020, the average rate of colorectal cancer incidence in the Russian Far east was 15.29 ± 0.33 per 100,000 men (2019: 15.35 ± 0.36) with an annual percent decrease of 5.40% since 2008. The corresponding rate increased to 12.92 ± 0.23 (2019: 12.98 ± 0.25) per 100,000 women with an annual percent increase of 5.95 %. By the end of the study period the number of new cancer cases increased to 13.2 % (2008: 1.3 %). The percent of morphological confirmation of the diagnosis was lower than in the Russian Federation as a whole (93.4 % versus 96.0; 2008: 84.3 %). The number of patients followed-up for 5 and more years was lower than in the Russian Federation as a whole (52.7 % versus 55.0 %; 2008: 41.9 %). The quality of the cancer service activity was marked by the index of reliability of registration, which was not lower than 0.40 in any of the territories of the district. The average colorectal cancer mortality rate in men was 8.73 ± 0.12 per 100,000 population (2019: 8.72 ± 0.13), which exceeded that in women (6.83 ± 0.10; 2019: 7.37 ± 0.53). The death rate within the first year after diagnosis decreased to 25.0 % (2008: 34.3 %). Conclusion. Unfortunately, the work of primary healthcare organizations responsible for early detection of cancer has not led to significant changes in the incidence rates. (2020: 13.02 0/0000; 2008: 12.9858 0/0000) and mortality rates (2020: 7.4558 0/0000; 2008: 7.6158 0/0000). Cancer screening programs aimed not only at the early cancer detection, but also at the formation of groups being at high risk of cancer are necessary for improving cancer care in the Russian Far east region. These programs should be accompanied by the training of professional staff and the development of modern diagnostic and treatment regimens.
Features of lymph node metastasis depending on intratumoral heterogeneity of non-small cell lung cancer in patients with different morphological changes in the bronchial epithelium
Authors: Zavyalova M. V. , Loos D. M. , Pismenny D. S. , Durova A. A. , Andryukhova E. S. , Rodionov E. O. , Miller S. V. , Tuzikov S. A. , Pankova O. V. , Tashireva L. A. , Vtorushin S. V. , Perelmuter V. M.
Published: November 2022

The aim of the study: to examine the relationship between the morphological diversity of non-small cell lung cancer and the frequency of lymph node metastasis in groups of patients with different epithelial conditions in the bronchi adjacent to the tumor. Material and methods. Surgical specimens from 90 patients with non-small cell lung cancer, who were treated in the Thoracoabdominal Department Of The Research Institute Of Oncology Of The Tomsk National Research Medical Center in the period from 2009 to 2017 were studied. The histological type of cancer was determined according to the who classification (2020). Lepidic, acinar, papillary, micropapillary, solid and solitary tumor cells were isolated in the parenchymal component of adenocarcinoma. In the parenchymal component of squamous cell carcinoma, 5 types of structures were distinguished: with keratinization, consisting of atypical cells of the prickly type without keratinization, consisting of atypical cells of the basaloid type, built of atypical cells with pronounced polymorphism, single tumor cells. Results. In patients with isolated basal cell hyperplasia, acinar (37 %), papillary (29 %) and solid (27 %) patterns were found less frequently in cases with metastatic regional lymph nodes compared to those without metastatic lymph nodes (63 %; p=0.05; 71 %; p=0.05; 73 %; p=0.01, respectively). In patients with isolated basal cell hyperplasia of the bronchial epithelium, in cases with the presence of lymph node metastasis in the parenchymal component of squamous cell carcinoma, structures 1 (with keratinization) (17 %), 2 (spiky pattern) (33 %) and 4 (polymorphic pattern) (29 %) were less frequently detected compared to those without metastases in regional lymph nodes (83 %; p=0.01; 67 %; p=0.02 and 71 %; p=0.01, respectively). In patients with a combination of basal cell hyperplasia and squamous metaplasia, a spiny pattern (65 %), a basaloid pattern (100 %), a polymorphic pattern (82 %) and single tumor cells (89 %) were more frequently detected in cases with metastatic lymph nodes than in cases without metastatic lymph nodes (35 %; р=0.04; 0 %; р=0.01; 18 %; р=0.01; 11 %; р=0.01, respectively). Conclusion. The data obtained clarify the available information on the significance of the morphological heterogeneity of the tumor for predicting the course of adenocarcinoma and squamous cell carcinoma of the lung.
Current trends and outcomes of surgical treatment of colorectal cancer with liver metastasis
Authors: Shabunin A. V. , Bedin V. V. , Grekov D. N. , Tavobilov M. M. , Drozdov P. A. , Lebedev S. S. , Karpov A. A. , Chechenin G. M. , Tsurkan V. A.
Published: November 2022

Aim. To analyze multimodal treatment outcomes in patients with liver metastases from colorectal cancer, who were treated at multidisciplinary cancer clinic. Material and methods. From 2007 to 2021, 315 colorectal cancer patients with liver metastases underwent liver resections (201, 63.8 %), radiofrequency ablation (RFA) (29, 9.2 %), microwave ablation (MWA) (22, 6.9 %), transarterial chemoembolozation (TACE) in combination with RFA (22, 6.9 %), and TACE + RFA + TACE combination (41, 13.2 %) at the department of liver and pancreas surgery, Moscow Botkin Clinical Hospital. Results. A 90-day mortality rate was 1.9% in 6 patients who underwent liver resection. Postoperative complications after liver resection were observed in 49 patients (24.3 %). The overall 5- and 10-year survival rates after liver resection were 38.8 % and 23.2 %, respectively. The factors of poor prognosis after liver resection were: age over 70 years (p=0.03), localization of the primary tumor in the right half or rectum (p=0.037), three or more metastatic foci in the liver (p=0.01), maximum size of the tumor of more than 5 cm (p=0.021), synchronous colorectal liver metastases (p=0.039), and bilobar colorectal liver metastases (p=0.007). Postoperative complications after RFA, TACE + RFA, TACE + RFA + TACE WERE 5.8 %, 9.1 % and 7.3 %, respectively. In patients with a size of metastases of no more than 3 cm, the 3-year disease-free and overall survival rates after rfa were 45.8 % and 54.2 %, respectively. In patients with a size of metastases from 3 to 5 cm, the 3-year disease-free and overall survival rates after TACE + RFA + TACE were 56.1 % and 63.4 %, respectively. Conclusion. In colorectal cancer patients with liver metastases, multimodal treatment within a multi-disciplinary setting demonstrated significant improvements in their survival.
Budaya Masyarakat Bugis dalam Aspek Perkahwinan, Komunikasi dan Makanan Warisan
Authors:   Center for General Studies and Co-Curriculum, Universiti Tun Hussein Onn Malaysia, Johor, MALAYSIA, Saleh Nor Shela , Rosli Mohd Shafie ,   Faculty of Social Sciences and Humanities, Universiti Teknologi Malaysia, Johor, Malaysia, Syamsuri Andi Sukri ,   Fakultas Adab dan Humaniora, Universitas Islam Negeri Alauddin Makassar, Sulawesi Selatan, Indonesia
Published: November 2022

The Bugis tribe’s customs, culture and heritage must be preserved because they have a distinct and valuable value and identity. However, many generations, particularly the young, are increasingly hazy about and unaware of the Bugis tribe’s customs and culture. Many younger generations appear to have forgotten their ancestors and origins, which is causing this phenomenon. Thus, this study highlights three main objectives of the culture of the Bugis community in aspects of daily life, namely, identifying the Bugis tribe’s wedding culture, identifying communication among the Bugis tribe and identifying the Bugis tribe’s heritage food. This study was conducted both quantitatively and qualitatively. The questionnaire was distributed to social media respondents by the researcher using the Google Forms application. The questionnaire was distributed using a purposive sampling method to only Bugis tribe respondents. According to the findings of the study, 69 people completed the questionnaire. An observational study was also conducted by the researcher in Kampung Tampok Laut, Benut, Johor. The researchers participated in several ceremonies and gatherings in order to strengthen their research findings. The study’s findings show that the Bugis still maintain their customs and culture, whether in the context of marriage culture, communication, or heritage food. This study may have an indirect impact on the Bugis community and ensure that each generation can maintain the Bugis tribe’s identity, particularly in the aspects studied.
How I Managed to Integrate: An Analysis of the Protective Factors in Determining Good Life Events and Turning Points of Three Former Prisoners in Malaysia
Authors:   School of Applied Psychology, Social Work and Policy, Universiti Utara Malaysia, Kedah, Malaysia, Jasni Mohd Alif ,   Institute for Psychotherapy, Correctional and Rehabilitation (iPSYCORE), Universiti Utara Malaysia, Kedah, Malaysia, Abu Bakar Ah Siti Hajar ,   Department of Social Administration and Justice, Faculty of Arts and Social Sciences, Universiti Malaya, Kuala Lumpur, Malaysia, Mohd Nasir Norruzeyati Che ,   School of Applied Psychology, Social Work and Policy, Universiti Utara Malaysia, Kedah, Malaysia
Published: November 2022

Imprisonment impacts the life events and turning points of former prisoners upon release. The challenges faced during societal re-integration are contributing factors that shape the life events of former prisoners upon release and subsequently determine their turning point. This study aims to prove that positive life events will cause former prisoners to shape positive turning points after release. Criminal justice studies have since strived to understand the factors that cause former prisoners to repeat their crimes after being released from prison. However, in Malaysia, not many works have explored the factors that cause former prisoners to cease committing a crime. Besides, the successful re-integration of these prisoners is still understudied. The researchers conducted a qualitative study in Kuala Lumpur with 19 former prisoners. The results revealed that 16 informants had repeatedly committed crimes, while only three managed to desist. This study will describe the views and experiences of the three former prisoners (desisters) on how they desist from crime during re-integration. Only three desisters were considered and did not include 16 other recidivist informants since the objective of this study was to identify the success factors for re-integration and to understand the protective factors of former prisoners during re-integration into society. The crucial findings were also discussed, including family acceptance, the presence of a supportive spouse, employment, avoiding negative peers, no drug addiction and being healthy. These factors managed to prevent the former prisoners from committing crimes again.
ANAYASA MAHKEMESİ’NİN İŞ İLİŞKİSİNDE İŞVERENİN EŞİT DAVRANMA BORCUNA İLİŞKİN KARARI VE DÜŞÜNDÜRDÜKLERİ (2016/5824 NO.LU 28/12/2021 TARİHLİ BURCU REİS BAŞVURUSU)
Authors: DULAY YANGİN Dilek , ÖZER Hatice Duygu
Published: November 2022

İşverenin eşit davranma borcu iş hukukunda, ayrımcılık yasağı ve dar anlamda eşit davranma borcu çerçevesinde ikili görünüme sahiptir. İşverenin benzer durumdaki işçileri arasında ayrımcılık temellerine dayalı olmayan, farklı muamelede bulunmasının sonuçlarının ele alındığı çalışmada, konu Anayasa Mahkemesi’nin 2016/5824 no.lu 28/12/2021 tarihli Burcu Reis başvurusu özelinde değerlendirilmiştir. Anılan kararda işverenin benzer durumdaki küçük çocuğu olan kadın işçilerinden bir kısmını işyerinde açmış olduğu kreş imkanından yararlandırmasına karşın, başvurucuyu sebebi açıkça ortaya konulamayan bir şekilde yararlandırmamış olması, Anayasa Mahkemesi tarafından eşitlik ilkesine aykırı bulunarak, ortaya çıkan ayrımcılık yasağının ihlalinin sonuçlarının ortadan kaldırılması için iş yargısının yeniden yargılama yapmasına karar verilmiştir. Yargıtay’ın yerleşik içtihadına göre ise, İş Kanunu m.5 hükmünün yaptırımını teşkil eden ayrımcılık tazminatı sadece ayrımcılık temelli farklı muameleye maruz kalan işçiler için söz konusudur. Oysa Anayasa Mahkemesi tarafından verilen karar, işverenin eşit davranma borcuna aykırı olan tüm durumlarda anılan tazminatın ödenmesini sağlamaya yönelik bir açılım sağlayacak niteliktedir. Bu sonuç, İş Kanunu m.5’deki farklı muameleye maruz kalan işçinin üzerindeki ispat yükü açısından da işçi lehine sonuç doğuracak niteliktedir.