bluuebunny/crossref_metadata_2025 huggingface dataset:
MARTYN MATVIYOVYCH TEREHOVSKYI (1740-1796) AND IMPROVEMENT OF TEACHING IN THE HIGHER MEDICAL SCHOOL
Authors: Vasyliev Yuriy
Published: April 2023

Objective: to summarize the main facts of M. M. Terekhovskyi’s biography based on a critical analysis of publications and, at the same time, to highlight his contribution to the improvement of teaching in higher medical school.
Materials and methods. Published materials were used as historical sources. The historical method was the main research method in the article.
Results. We performed an analysis of the literature about prof. Terekhovskyi. For the first time, his role in the reforms of higher medical education in the late 18th – early 19th centuries was clarified.
The first critical analysis of the literature about M. M. Terekhovskyi, published over more than a century and a half, made it possible to identify erroneous statements and typos. It was found that the first publication about him appeared in 1845, that is, half a century after his death. It was a brief biographical note in the dictionary of Metropolitan Eugene. It was proved that the main and most complete life description of Professor Terekhovskyi was his biography written by Ya. A. Chistovich (1883), which was based on archival materials and supplemented with archival findings by M. K. Borodii (1984). The fundamental study of his contribution to science was represented by the work of S. L. Sobol (1948, 1963). It was shown that the charter of 1792 of the higher medical school (academy), which Professor Terehovskyi took part in, served as the basis for the staff of the St. Petersburg Medical and Surgical Academy in 1808. The charter of 1792 for the first time included Medical Police (Politia Medica), which was later transformed into Social Hygiene and Public Health, as one of the teaching subjects in the higher medical school. Then it was enshrined in the charter of 1806, which was written by the founder of this science, J. P. Frank. The study made it possible to identify gaps in the biography of M. M. Terekhovskyi. Thus, the date and month of his birth are still unknown; it is not clear who his mother was, whether he had his own family (wife, children), and whether he received a scholarship from Princess Ye. D. Golitsyna. With this regard, further archival searches are needed to confirm Professor Terekhovsky’s authorship of the handwritten essay «Opinion on the correction of medical sciences.»
The Phenomenon of the Media Image of the Region in Conflictological Discourse (on the example of the Chechen Republic)
Authors: Ryumshin S. A. , Khaguev R. R.
Published: April 2023

The article reveals some problems of the content of the media image and the process of its formation against the background of the escalated political and economic confrontation. The authors update some characteristics of the media image phenomenon and its role in the development of the region and ensuring its national sovereignty. The research is based on the analysis of the media image of the Chechen Republic as the most complex from historical, confessional, political and other points of view. An important aspect of the formation of a positive content of the media image of Chechnya is the media image of its head. The phenomenon of the media image of the region is presented by the authors in its influence on the formation of the worldview of the society, fullness of emotional, semantic, subjective content. Based on the analysis of the experience of the Chechen Republic, the authors come to the conclusion that the promotion of a positive media image of the region in the media with the participation of regional and federal authorities can ensure the solution of the most acute socio-economic problems of the region as an integral part of the Russian state.
The Role of Storytelling in the Development of Social Identity (theoretical and applied aspects of research)
Authors: Kireeva O. F. , Kirillina N. V.
Published: April 2023

The paper represents theoretical and practical approaches to applying storytelling as modern technology for the transmission and representation of information. Storytelling has accompanied mankind throughout the ages of its civilized development, which is probably why storytelling is so effective in modern practices of managing public opinion. The authors offer the detailed definitions of the concepts of storytelling and narrative, and provide key sociological and philosophical concepts that determine the possibilities of storytelling in the formation of social identity. Storytelling is presented as a form of interactive sociocultural activity for the exchange of stories (meanings) and as a method of socio-cultural communication that can be used in various ways of managing public opinion and interaction in social groups (communities). The effectiveness of storytelling lies in establishing an emotional connection with the contact audience based on the identity, which engages, forms the loyalty and trust of the audience. In conclusion, the authors provide examples of the practical application of storytelling by companies and brands as a modern tool of communication, and draw the conclusions.
Particle dynamics on torsional galilean spacetimes
Authors: Figueroa-O'Farrill José , Görmez Can , Van den Bleeken Dieter
Published: April 2023

We study free particle motion on homogeneous kinematical spacetimes of galilean type. The three well-known cases of Galilei and (A)dS–Galilei spacetimes are included in our analysis, but our focus will be on the previously unexplored torsional galilean spacetimes. We show how in well-chosen coordinates free particle motion becomes equivalent to the dynamics of a damped harmonic oscillator, with the damping set by the torsion. The realization of the kinematical symmetry algebra in terms of conserved charges is subtle and comes with some interesting surprises, such as a homothetic version of hamiltonian vector fields and a corresponding generalization of the Poisson bracket. We show that the Bargmann extension is universal to all galilean kinematical symmetries, but also that it is no longer central for nonzero torsion. We also present a geometric interpretation of this fact through the Eisenhart lift of the dynamics.
The impact of conversion on market share in Indonesian Islamic banks
Authors: Nur Rianto Al Arif Mohammad , Nuraini Ihsan Dwi , Zulpawati  , Abdul Fatah Dede
Published: April 2023

The process of converting a conventional bank into a fully-fledged Islamic bank is becoming a popular alternative solution, alongside spin-off, for smaller banks. Two Indonesian banks, Bank of Aceh Sharia and Bank of NTB Sharia, completed this conversion in 2016 and 2018, respectively. This study uses a mixed-methods approach to examine the impact of this conversion on market share, using both quantitative regression with a dummy variable and qualitative analysis through focus group discussions with executive management and in-depth interviews with the Sharia supervisory boards of the two converted banks. The study found that the conversion positively impacted market share, with the default rate and level of capital also playing a role. Prior to conversion, the Indonesian sharia banking industry had less than a 5% market share, but after the conversion, it reached 6.7%. The two converted banks were able to increase their market share to 7% and 2%, respectively. These results suggest that converting into a full-fledged Islamic bank is a viable alternative solution for smaller conventional banks, rather than opting for spin-offs or mergers.
The effectiveness of technical trading strategies: Evidence from Indian equity markets
Authors: Tadas Harikrishna , Nagarkar Jeevan , Malik Sushant , K. Mishra Dharmesh , Paul Dipen
Published: April 2023

The purpose of the study was to analyze the effectiveness of technical trading strategies in trading stocks of selected Indian companies represented in the Nifty 50 Index. The research was done using secondary data from January 2022 to August 2022. Hourly share prices of 14 largest companies as per market capitalization from 14 different sectors from the Nifty 50 Index were considered as a part of the study. Simple Moving Average, Exponential Moving Average – Relative Strength Index and Bollinger Bands – Relative Strength Index – strategies considered in the study. It was found that strategy based on Bollinger Bands and Relative Strength Index performed the best. Performance was considered with respect to both the number of stocks having a net profit and the number of stocks that were able to outperform the buy-and-hold strategy for the time period considered. The study considered several combined strategies and performance indicators, whereas previous studies used limited indicators. Out of the 14 stocks considered, the Simple Moving Average strategy was able to generate net profit for 8 stocks and it outperformed the buy-and-hold strategy for 6 stocks, Exponential Moving Average – Relative Strength Index strategy generated net profit for 6 stocks and it outperformed the buy-and-hold strategy for 5 stocks, and the Bollinger Bands – Relative Strength Index generated net profit for 11 stocks and it outperformed the buy-and-hold strategy for 10 stocks. The Bollinger Bands – Relative Strength Index strategy was able to outperform as it was more dynamic and entered and exited positions actively.
Effects of hydrolysis degree on the functional properties of hydrolysates from sour cherry kernel protein concentrate
Authors: Cingöz Ali , Yildirim Metin
Published: April 2023

During the processing of sour cherries into different foodstuffs, a large amount of kernels is produced as waste material, which creates a significant disposal problem for the food industry. Sour cherry kernels containing 25.3–35.5% of protein can be used as a functional protein source in food production. Therefore, we aimed to study the effects of hydrolysis degree on the sour cherry kernel protein hydrolysates.

Proteins were extracted from the defatted flour by isoelectric precipitation. The resulting protein concentrate was hydrolyzed (5, 10, and 15% hydrolysis) using Alcalase to yield hydrolysates. We determined their oil and water holding, emulsifying, gelation, and foaming properties, as well as apparent molecular weight distribution and proximate compositions.

No protein fractions greater than an apparent molecular weight of about 22 kDa were present in the hydrolysates. The hydrolysis of the protein concentrate mostly led to an increase in protein solubility. As the degree of hydrolysis increased from 5 to 15%, the water holding capacity of the hydrolysates decreased from 2.50 ± 0.03 to 2.03 ± 0.02 g water/g, indicating its deterioration.

The hydrolysates obtained at different degrees of hydrolysis had a better solubility than the intact protein concentrate. The oil holding capacity, the foaming stability, and the least gelation concentration of the protein concentrate could not be considerably improved by hydrolysis. In contrast, its emulsifying activity index and foaming capacity could be increased with a limited degree of hydrolysis (up to 10%).
Using casein and gluten protein fractions to obtain functional ingredients
Authors: Prikhodko Denis , Krasnoshtanova Alla
Published: April 2023

Today, the food industry widely uses both animal and plant proteins. Animal proteins have a balanced amino acid composition, while plant proteins have more pronounced functional properties. However, both types of proteins can act as allergens, which limits their practical application. Therefore, we aimed to select optimal conditions for obtaining hypoallergenic mixtures based on casein hydrolysates and gluten proteins, which have good functional properties and a balanced amino acid composition.

We used wheat flour (Makfa, Russia) with 12.6% of crude protein and 69.4% of starch, as well as rennet casein (Atletic Food, Russia) with 90% of protein. The methods included the Lowry method, the Anson method, Laemmli electrophoresis, ion-exchange chromatography, and the enzyme-linked immunosorbent assay.

Protex 6L was an optimal enzyme preparation for the hydrolysis of gliadin, while chymotrypsin was optimal for the hydrolysis of glutenin and casein. The optimal amount for all the enzymes was 40 units/g of substrate. We analyzed the effect of casein, glutenin, and gliadin enzymolysis time on the functional properties of the hydrolysates and found that the latter had relatively low water- and fat-holding capacities. The highest foaming capacity was observed in gliadin hydrolysates, while the highest emulsifying capacity was registered in casein and glutenin hydrolysates. Further, protein enzymolysis significantly decreased allergenicity, so the hydrolysates can be used to obtain functional additives for hypoallergenic products. Finally, the mixtures of casein hydrolysate and gliadin or glutenin hydrolysates had a balanced amino acid composition and a high amino acid score. Also, they retained high emulsifying and foaming capacities.

The study proved the need for mixtures based on wheat protein and casein hydrolysates, which have good functional properties and hypoallergenicity.
Evaluation of hydraulic efficiency of lined irrigation channels – A case study from Punjab, Pakistan
Authors: Zakir-Hassan Ghulam , Kahlown Muhammad Akram , Punthakey Jehangir F. , Shabir Ghulam , Aziz Marjan , Sultan Muhammad , Ashraf Hadeed , Nawaz Qurrat ul ain , Majeed Faizan
Published: April 2023

Indus Basin Irrigation System (IBIS) in Pakistan is the backbone of agriculture in the country. The IBIS provides irrigation support to agricultural lands across the country; however, hydraulic efficiency of the water conveyance system is impacted due to seepage losses. The lining of irrigation channels is considered a potential solution for improving hydraulic efficiency. Therefore, this study explores the impact of canal lining on the hydraulic efficiency of the canals in the Punjab province of Pakistan. Overall, 14 channels/distributaries/minors (total length 226 km) were monitored in terms of hydraulic performance in different irrigation zones. Hydraulic, geometrical, and socioeconomic parameters of channel/distributaries/minors including roughness coefficient, sediments, flow velocity, wetted parameter, breaches, theft cases, bed, side slope, water surface profile, hydraulic radius, crop yield, and vegetation growth area have been experimentally observed. Obtained results have been compared with the design and pre-lining data. Ten seepage tests using the inflow -outflow method and eight seepage tests using the ponding method were conducted to estimate seepage losses. Results indicate that almost all the parameters varied from the design values. A detailed comparison of the socioeconomic parameters has been carried out. Results from seepage tests show an approximately 78% reduction in losses.
Assessment of the induced effect of selected iron hydroxysulfates biosynthesized using Acidithiobacillus ferrooxidans for biomineralization of acid mine drainage
Authors: Wang Heru , Guo Qian , Guo Zehao , Luo Haowei , Li Honghu , Yang Jun , Song Yongwei
Published: April 2023

Soluble iron and sulfate in acid mine drainage (AMD) can be greatly removed through the formation of minerals facilitated by seed crystals. However, the difference in the effects of jarosite and schwertmannite as endogenous seed crystals to induce AMD mineralization remains unclear. This paper intends to study the effect of Fe2+ oxidation and Fe3+ mineralization in the biosynthesis of minerals using different addition amounts and methods of jarosite or schwertmannite. The results showed that the addition amount and method of different seed crystals had no effect on the Fe2+ bio-oxidation but would change the Fe3+ mineralization efficiency. With the same amount of seed crystals added, jarosite exhibited a higher capacity to promote Fe3+ mineralization than schwertmannite. Adding seed crystals before the initiation of Fe2+ oxidation (0 h) could significantly promote Fe3+ mineralization efficiency. With the increase of seed crystals, jarosite could not only shorten the time required for mineral synthesis but also improve the final mineral yield, whereas schwertmannite could only shorten the time required for mineral synthesis. When Fe2+ was completely oxidized to Fe3+ (48 h), the supplementary of jarosite could still effectively improve Fe3+ mineralization efficiency, but the addition of schwertmannite no longer affected the final mineralization degree.
Advanced treatment of secondary effluent by the integration of heterogeneous catalytic ozonation and biological aerated filter
Authors: Liu Xinghao , Yang Zhaoguang , Peng Jiayun , Chen Leilei , Yang Ying , Li Haipu , Yang Liqun
Published: April 2023

The advanced treatment of secondary effluents was investigated by employing heterogeneous catalytic ozonation integrated with a biological aerated filter (BAF) process. The results indicated that catalytic ozonation with the prepared catalyst (MnxCuyOz/γ-Fe2O3) significantly enhanced the performance of pollutant removal and broke up macromolecules into molecular substances by the generated hydroxyl radicals. These molecular substances were easily absorbed by microorganisms in the microbial membrane reactor. In the BAF process, chemical oxygen demand (COD) (chemical oxygen demand) decreased from 54.26 to 32.56 mg/L, while in catalytic ozonation coupled with the BAF, COD could be reduced to 14.65 mg/L (removal ratio 73%). Under the same condition, NH4+-N decreased from 77.43 to 22.69 mg/L and 15.73 mg/L (removal ratio 70%) in the BAF and the catalytic ozonation coupled with BAF, respectively. In addition, the model that highly correlated influent COD to effluent COD and reactor height for filler could predict the removal ratio of COD of the BAF system. Based on the microbial community analysis, ozone in the solution had a certain screening effect on microorganisms, which helped to better adapt to the ozone-containing environment. Therefore, the integrated process with its efficient, economic, and sustainable advantages was suitable for the advanced treatment of secondary effluents.
Resveratrol Attenuates Hydrogen Peroxide-induced Injury of Rat Ovarian
Granulosa-lutein Cells by Resisting Oxidative Stress via the SIRT1/Nrf2/ARE
Signaling Pathway
Authors: Cai Minghui , Wang Jiao , Sun Haijuan , Guo Qi , Zhang Chi , Yao Haixu , Zhao Chen , Jia Yuhan , Zhu Hui
Published: April 2023

Introduction:

This paper aims to reveal the molecular mechanism of resveratrol against oxidative
stress and cell injury. The ovarian granulosa-lutein cell injury and apoptosis induced by oxidative stress may be
responsible for female luteal phase deficiency. The antioxidant function of resveratrol has been confirmed; however,
its effect on the expression of antioxidant enzymes and regulatory mechanisms in ovarian granulosa-lutein
cells remains unclear.

Objective:

This study aimed to investigate the role of the SIRT1/Nrf2/ARE signaling pathway in the effect of
resveratrol on the hydrogen peroxide-induced injury of rat ovarian granulosa-lutein cells.

Methods:

In this study, ovarian granulosa-lutein cells extracted from 3-week female SD rats were treated with
200 μM H2O2 in the presence or absence of 20 μM resveratrol. siRNA-SIRT1 and siRNA-Nrf2 were used to inhibit
the expression of SIRT1 and Nrf2, respectively. Cell counting kit 8 (CCK-8), cellular morphology, progesterone
secretion, and estradiol were used to evaluate cell injury. Hoechst 33258 staining was used to measure
cell apoptosis. DHE staining, DCFH-DA staining, malondialdehyde content, protein carbonyl content, total antioxidant
capacity and SOD viability were used to estimate the levels of oxidative stress. Western blot analysis
was used to detect the levels of apoptosis-related proteins, and SIRT1/Nrf2/ARE signaling pathway-related proteins.

Results:

The H2O2 treatment-induced rat ovarian granulosa-lutein cells injury was shown as decreased cell viability,
impaired cellular morphology, and decreased levels of progesterone and estradiol. The H2O2 treatment also
exacerbated cell apoptosis demonstrated as more apoptotic cells stained by Hoechst staining, decreased level
of anti-apoptosis protein Bcl-2 and increased level of pro-apoptosis protein Bax. These effects of cell injury and
apoptosis induced by H2O2 can be ameliorated by resveratrol. Resveratrol also alleviated oxidative stress induced
by H2O2, supported by decreased superoxide anion and cellular total ROS, decreased malondialdehyde
and protein carbonyl levels, and increased total antioxidant capacity and SOD viability. Western blot results demonstrated
resveratrol reversed the H2O2-induced decrease in levels of antioxidant enzymes containing ARE sequences
and activated SIRT1/Nrf2 pathway. Further treatment by siRNA-Nrf2 suggested resveratrol could not
activate the expression of antioxidant enzymes under a condition of inhibition of Nrf2.

Conclusion:

This study demonstrates that resveratrol attenuated oxidative stress to protect H2O2-induced rat
ovarian granulosa-lutein cell injury and apoptosis via SIRT1/Nrf2/ARE signaling pathway.
The Severity of Adverse Events is Associated with the Age of Hospitalized Patients: A Retrospective Study
Authors: Moya-Salazar Jeel , Añanca Graciela , Goicochea Eliane A. , Rojas-Zumaran Victor , Moya-Salazar Belén , Contreras-Pulache Hans
Published: April 2023

Background:

Adverse events (AE) are unintentional injuries or harm that occur during medical care. These represent a public health problem, and they are one of the main causes of death in the world.

Objective:

The objective of the study was to determine AEs derived from nursing care in hospitalized patients, as well as to estimate their frequency according to severity, follow-up, and type of care service.

Methods:

We undertook a retrospective study in hospitalized patients. EA by severity (no damage, irreversible damage, disability, and death), types (pressure ulcers (PUs), falls, phlebitis, and blood transfusion), and demographic data (age and gender) were taken into account. Damage severity was determined according to the guidelines of the Peruvian Ministry of Health.

Results:

We obtained 127 reports (55.9% women, mean age of 28+8 years). The main EA were PUs (57.5%), followed by phlebitis (20.5%) and falls (19.7%). Most of the AEs have been followed up, and almost all the AEs occurred during hospitalization. In addition, being older was associated with AE severity (p=0.002), as there were reports of 2 (1.6%) cases of death, and half of the cases resulted in the disability of patients > 48 years old.

Conclusion:

PUs were the most frequent AE. They affected younger patients, and their severity was associated with older age. It is important for health professionals to recognize and notify AEs in order to ensure the patients’ well-being; also, health institutions needs to be encouraged for improving their risk reduction programs.
Herbal Medicines Used for the Management of COVID-19
Authors: Kumar Virender , Kumar Yogesh , Huria Rajat , Kumar Suryadev , Kalson Tarun , Jangra Deepak , Kumar Davinder , Mangla Bharti
Published: April 2023

A worldwide outbreak of respiratory illnesses has been caused by coronavirus disease
(COVID-19). Traditional healers have used herbs and dietary plants for centuries to treat various conditions.
This review discusses the prevention of COVID-19, multiple herbs used in the treatment of
COVID-19, and their future perspectives. Various databases, such as PubMed, Web of Science, Scopus,
Medline, and Google Scholar, were searched for articles related to herbal products' antiviral effects using
different keywords: herbal, SARS-CoV-2, plant-derived drugs, COVID-19, coronavirus, etc. Herbal
treatment has been used as a contemporary alternative medicine for COVID-19. By inhibiting the replication
and entry of SARS-CoV-2 into host cells, herbs can inhibit the pathogenesis of COVID-19. This
article discusses COVID-19 infection, its salient features, spread, the life cycle of coronavirus, active
response to coronavirus, proposed treatment, and herbal drugs used in the prevention and treatment of
COVID-19.
ЗВ’ЯЗОК МІЖ ЗМІНАМИ КОНЦЕНТРАЦІЇ МАЛОНОВОГО ДІАЛЬДЕГІДУ ТА ПОКАЗНИКАМИ ЛІПІДНОГО СПЕКТРУ КРОВІ У ПАЦІЄНТІВ З СТАБІЛЬНОЮ ІШЕМІЧНОЮ ХВОРОБОЮ СЕРЦЯ ТА СУПУТНЬОЮ АРТЕРІАЛЬНОЮ ГІПЕРТЕНЗІЄЮ
Authors: Д. А. Волинський  , І. П. Вакалюк
Published: April 2023

Ішемічна хвороба серця (ІХС) і супутня артеріальна гіпертензія (АГ) – ключові проблеми сучасної кардіології. В основі атерогенезу, який відіграє вирішальну роль в прогресуванні обох патологій, лежить оксидативний стрес і ендотеліальна дисфункція. Лабораторними маркерами для оцін- ки перебігу вказаних процесів є концентрація загального холестерину (ЗХ), ліпопротеїдів низької густини (ЛПНГ) та малонового діальдегіду (МА). Вивчення взаємозв’язків між змінами рівнів цих показників може стати перспективним напрямком в діагностиці ІХС та АГ і сприятиме покра- щенню і оптимізації медикаментозного лікування. Метою дослідження є виявити зв’язок між змінами концентрації МА та ЗХ і ЛПНГ у пацієнтів з стабільною ІХС з та без супутньої АГ. У дослідження включено 131 паці- єнтів із стабільною ІХС і АГ. Хворі були розділені на 2 групи: 1) 80 хворих із стабільною ІХС та супутньою АГ; 2) 51 хворих із стабільною ІХС без супутньої АГ. В ході дослідження ми оцінювали коливання рівнів МА. Ліпід- ний спектр крові оцінювався за рівнем в сироватці крові ЗХ, ЛПНГ. Рівень МА у групі пацієнтів із супутньою АГ достовірно вищий. Ми встановили слабкий прямий кореляційний зв’язок між МА і ЗХ, МА і ЛПНГ у групі хво- рих на ІХС із супутньою АГ. У пацієнтів без патологічних коливань арте- ріального тиску ми виявили слабкий зворотній кореляційний зв’язок. Нам вдалося встановити зв’язок між змінами концентрації МА та ЗХ і ЛПНГ у пацієнтів з стабільною ІХС з та без супутньої АГ, що підтверджує сут- тєвий вплив оксидативного стресу та ендотеліальної дисфункції, які є не- від’ємними супутниками АГ, на ліпідний спектр крові.

Ключові слова: ішемічна хвороба серця, артеріальна гіпертензія, окси- дативний стрес, малоновий діальдегід, ендотеліальна дисфункція.
Biology and morphology of the ontogenetic development of Allogalumna (Acrogalumna) longipluma (Berlese, 1904) (Oribatida: Galumnidae). New record for Mexico
Authors: Revelo-Tobar Harol , Estrada-Venegas Edith G. , Equihua-Martínez Armando , Valdez-Carrasco Jorge
Published: April 2023

Allogalumna (Acrogalumna) longipluma (Berlese, 1904) es una especie de amplia distribución, se reporta por primera vez en territorio mexicano. Los ejemplares fueron colectados en muestras de suelo de bosque de encino-pino y huerta sembrada con aguacate (Persea americana) en el municipio de Uruapan, Michoacán. El objetivo de este trabajo es proporcionar mayor información sobre la biología, comportamiento y morfología de todos los estadios de desarrollo en condiciones de laboratorio. El ciclo de vida desde la oviposición hasta la muerte del adulto fue de 217 ± 69.9 días, el estado de huevo tuvo la mayor duración 10.1 ± 1.8 días, seguido de la tritoninfa 9.4 ± 2.6; la vida adulta fue la de mayor variabilidad. Se describen e ilustran los cambios de tamaño, morfología, esclerotización, sistema octotáxico y quetotaxia del cuerpo de juveniles y adultos.
Восстановление меди из оксидов при нагревании в воздухе
Authors: Пилягин М.В. , Тагиров Л.Р.
Published: April 2023

The paper presents the results of experiments on the reduction of copper oxides formed during the heat treatment of metallic copper samples in air. A necessary condition is the presence of a muffle made of a material with a higher electron affinity (lower standard electrode potential) compared to copper. Replacing nitrogen in the composition of the atmosphere with an equal proportion of argon does not change the observed redox pattern. Our results indicate an electrochemical mechanism for the reduction of copper oxides in a steel muffle, in which oxygen plays the role of a charge carrier.
T﻿he role of nerve growth factor (NGF) in the pathogenesis of leprosy
Authors: Lutsenko A. V. , Saroyants L. V.
Published: April 2023

Leprosy is a chronic infectious disease caused by M. leprae with a primary lesion of the skin and peripheral nervous system. Currently, clinicians using bacterioscopic studies of scarification and skin biopsy mainly diagnose leprosy. However, the development and application of new diagnostic criteria, especially those associated with damage to nerve fibers, remains an urgent task of modern leprology. This review considers the important role of neurotrophic factor (nerve growth factor, NGF) in the pathogenesis of nervous system damage in leprosy and establishes the relationship between NGF levels and forms of the disease. The review includes data from foreign and domestic articles; the search was carried out using the “Scopus”, “PubMed”, “Web of Science”, “elIBRARY” databases.
A clinical case of a familial form of hereditary metabolic disease from the group of peroxisomal diseases (D-bifunctional protein deficiency) in the neonatal period
Authors: Berezhanskaya S. B. , Afonin A. A. , Vostrikh N. N. , Lazareva K. I. , Loginova I. G. , Kravchenko L. V. , Medoyan A. V. , Monat L. I.
Published: April 2023

A clinical case of a familial form of peroxisomal D-bifunctional protein (DBP) deficiency (OMIM 261515) with an unfavorable (fatal) outcome caused by a mutation in type 4 17ß-hydroxysteroid dehydrogenase (HSD17B4) with a nucleotide replacement of chr5:118788316G>A in the homozygous state is presented. (D-bifunctional protein deficiency or 17-beta-hydroxysteroid dehydrogenase IV deficiency). Bifunctional protein deficiency is an autosomal recessive birth defect of peroxisomal fatty acid oxidation. The total incidence of morbidity is one case per 50,000 newborns. Most peroxisomal disorders manifest in the early neonatal period with an extremely severe course and phenotypic features, which facilitates their diagnosis. This is the difference between them and diseases with a milder and prolonged course, which debuted at different age periods, often had no neonatal or infantile symptoms and were accompanied, in some cases, by satisfactory cognitive functions. The purpose of the report was to highlight the clinical manifestations, variants of the course and complexity of the diagnosis of peroxisomal disorders to a wide range of doctors of different specialization: in the field of perinatology, pediatrics, neurology, genetics, endocrinology.
Men's ND1 gene genetic makeup Toxoplasmosis and Oligospermia affecting couples' infertility
Authors: S. Muhsin Salwa , A. Al-Safar Montaha , Mahmood Sarah A.
Published: April 2023

Introduction: Toxoplasma infection was higher in infertile couples than fertile couples, probably due to anti-sperm antibodies that were higher in couples with Toxoplasmosis. Investigations of T. gondii infections in men with infertility showed that among 100 cases of men's infertility, 36% were serologically positive for Toxoplasma-IgG and IgM. It has been concluded that T. gondii can affect men's fertility and result in infertility. Materials and Methods: Selective infertile males were asked about days of sexual abstinence. Seminal fluid samples were collected following a minimum of 2 days and a maximum of 7 days from abstinence. Every patient was given a clean, wide mouth, sterile, dry, graduated plastic and warm disposable container. The samples were obtained by masturbation in a private room near the semen analysis lab to reduce seminal exposure to temperature fluctuations and control the time from collection to analysis. Results: For the ND1 gene, samples of 8 different fertility groups have been sequenced. These sequences have been compared to reference sequences taken from the NCBI database. Several mutations in various nucleotide positions of the ND1 regions have been detected in samples from multiple groups. The base substitution has been positioned on the nucleotides (nts) 3480, 3567, 3591, 3693, and 4216. The T to C evolution was notorious at nt 3480 in ND1 genes. The SNP was detected in an asthenospermia human (Sample code: 010480).

Keywords: Sequence, ND1 gen, Oligospermia Toxoplasmosis, Couples infertility
Millennials' Consumer Behavior in the Coffee Agroindustry: The Effect of Consumer Attitudes on Purchasing Decisions
Authors: Ismoyowati Dyah , Wuryandani Shafira , Wijayanti Fadhila Kurnia
Published: April 2023

Enjoying a good cup of coffee is gaining popularity among Indonesian millennials, particularly in metropolitan areas, with an annual growth rate of 6% in the last decade. Therefore, this study aimed to provide information for adjusting coffee shop marketing strategies by estimating the influence of consumer attitudes, in particular, motivation and perception, and lifestyle, on their purchasing decisions. We sampled 153 individuals (majorly aged 25 to 27 years, with a slight bias toward females) in Yogyakarta, Java, using an online survey with 33 questions on consumer attitudes, along with four demographic questions. The responses were converted to a Likert score and analyzed using multiple linear regression. Our results demonstrate that the consumer attitudes investigated collectively explained ~41%, with motivation and perception being the dominant factor (F = 51,401 ; p < 0.05). It showed that motivation and perception, and lifestyle variables significantly affected coffee shop purchasing decisions among millennials in Yogyakarta. At the same time, the F test revealed that they had a combined effect significantly. Therefore, coffee shop owners must consider consumers' motivation and perception, and lifestyle to increase millennial coffee shop consumers' loyalty in Yogyakarta.
Application of Liquid Smoke from Rubber Wood Clone PB-340 as Latex Coagulant and Preservation of Natural Rubber Coagulum
Authors: Sinaga Maria Magdalena , Marseno Djagal Wiseso , Manikharda Manikharda
Published: April 2023

The utilization of rubber wood waste in the form of liquid smoke has the potential to overcome environmental problems caused by the industry. Therefore, this study aimed to determine the potential of liquid smoke from rubberwood clone PB 340 to be used as a coagulant and preservative. Rubber wood waste was processed into liquid smoke using the pyrolysis method with a temperature of 400°C. Determination of the composition of liquid smoke was carried out using gas chromatography-mass spectrometry (GC-MS) analysis. The results showed that the rubber wood clone PB 340 contained 57.78% cellulose, 12.16% hemicellulose, and 19.01% lignin. Furthermore, volatile analysis with GC-MS showed that liquid smoke from rubber wood clone PB 340 contained 58 organic compounds. Some compounds in liquid smoke were phenols, furans, furfurals, acetic acid, and cyclopentene. The product was then tested for its performance as a latex coagulant at several concentrations of 5%, 10%, 15%, 20%, and 25% v/v, as well as storage time of 1, 7, and 14 days. The treated latex samples that had turned into coagulums were examined for their sheet quality parameters, including initial plasticity (P0), plasticity retention index (PRI), total volatile compounds, impurity, and ash content. The outcomes from all comparisons of pure liquid smoke concentrations and storage time of up to 14 days of the coagulum samples showed that in the initial plasticity value (P0), the plasticity retention index (PRI), volatile matter, ash content, and dirt content had met the applied Standard Indonesian Rubber (SIR).
Kata Tabu dalam Video PUBG Indonesia Kebodohan Bermain Saat Karantina: Bentuk, Fungsi dan Penyebab
Authors: Qurrota Ayun Hafizh
Published: April 2023

Penelitian ini mengambil objek material video Youtube berjudul PUBG Indonesia Kebodohan Bermain Saat Karantina. Pemilihan objek disebabkan adanya penggunaan kata tabu dalam interaksi antar tokoh yang ada dalam video. Tujuan dari penelitian ini adalah mendapatkan jenis-jenis kata tabu pada video, fungsinya dan penyebab digunakannya kata tabu. Pada penelitian ini metode pengumpulan data yang digunakan adalah metode simak dan catat. Dalam video ini didapati lima puluh data kata tabu, dengan acuan pengelompokan kata tabu yang disusun oleh Timothy Jay. Adapun untuk mengetahui fungsi dari kata tabu penelitian ini mengacu pada pandangan Wardhaugh tentang macam-macam fungsi kata tabu. Dan untuk menjawab apa penyebab dari penggunaan kata tabu, peneliti menganalisis dengan pendekatan yang dirumuskan Timothy Jay. Hasil dari penelitian ini adalah pertama, terdapat lima jenis kata tabu yaitu sexual references, scatological referents and disgusting object, animal names, insulting references to perceived pyschological or socisal deviations dan offensive slang. Kedua, fungsi penggunaan kata tabu adalah untuk menghina dan mencari perhatian. Ketiga, adapun penyebabnya adalah ekspresi emosi, candaan dan keakraban.
PHYTOCHEMICAL ANALYSIS AND MOLECULAR CHARACTERIZATION OF MORINGA OLEIFERA AND ITS ENDOPHYTIC FUNGI
Authors: PRIYANKA G. DEVI , SHOBHA  , S. D. SHRUTHI
Published: April 2023

Objective: Moringa oleifera Lam (Moringaceae) is a highly valued plant which has an impressive range of medicinal uses with high nutritional value. Different parts of the plant were being used for the treatment of illness due to the presence of various secondary metabolites that gives the plant anti-bacterial, anti-oxidant and other properties. These secondary metabolites are synthesized by endophytic organisms, which are present inside the tissues of plant.
Methods: ITS regions were amplified using a polymerase chain reaction for molecular identification. The sequences were analysed using BLAST n and DNA barcoding of plant was done for the identification of species. The organisms were refined on Potato Dextrose stock for identification of metabolites.
Results: It was found that fungi obtained are Aspergillus fumigatus and Tricoderma turrialbense with percentage identity of 96% and 98%, respectively, as obtained from NCBI BLAST; the metabolites were extracted with ethanol extract and Flavonoids and terpenoids are the main phytoconstituents present in endophytic fungi.
Conclusion: The results obtained support the medicinal properties of plant, which gets enhanced due to the presence of endophytic fungi present in them.
ANALYSIS AND CHEMICAL PROFILING OF HONEY USING 1H-NMR SPECTROSCOPY, FTIR SPECTROSCOPY AND TLC USING VARIOUS CHROMOGENIC REAGENTS FOR DERIVATIZATION
Authors: SAHOO MANAS RANJAN , VARRIER RAMESH R. , RAJENDRAN ANITHAKUMARI
Published: April 2023

Objective: Honey is a natural sweet substance known for various health benefits and is used in many traditional medicines and dietary supplements. It contains various bioactive constituents like sugars, amino acids, polyphenols, flavonoids and various minerals. Quality control of honey is an essential part for ensuring its health benefits and therapeutic usage. In the present study, honey was analyzed by using various spectroscopic approaches and physicochemical methods. Methods: The samples of honey were analyzed by Thin-layer Chromatography (TLC) derivatization, ATR-FTIR, and 1H-NMR fingerprint and the total phenolic content (TPC) and total flavonoid contents (TFC) were measured by Uv-Vis spectrophotometry and analysis were carried out for various physicochemical parameters of honey. Results: All the physicochemical parameters of the honey were as per the desired quality. The UV-Vis analysis was successfully used in the determination of total phenolics and flavonoid contents in the samples of honey. TLC analysis showed the presence of flavonoids, phytosterols, phenolics, sugars and carbohydrates in honey. The Thin-Layer chromatography analysis showed good resolution for various components of honey on the TLC plates. The FTIR analysis showed the presence of various functional groups characteristic of amino acids, carbohydrates and sugars, which was further supported by 1H NMR chemical profiling. Conclusion: In the present work, the application of various spectroscopic techniques and physicochemical tests were found to be useful in analysis of honey.
Applications of Pervious Concrete in Road Pavements
Authors: Samadhana
Published: April 2023

Abstract: Pervious concrete is a relatively new concept for rural road pavement, with increase into the problems in rural areas related to the low ground water level, agricultural problem. Pervious concrete has introduced in rural road as a road pavement material. Pervious concrete as a paving material has seen renewed interest due to its ability to allow water to flow through itself to recharge groundwater level and minimize storm water runoff. This introduction to pervious concrete pavements reviews its applications and engineering properties, including environmental benefits, structural properties, and durability. In rural area cost consideration is the primary factor which must be kept in mind. So that in rural areas costly storm water management practices is not applicable. Pervious concrete pavement is unique and effective means to meet growing environmental demands. By capturing rainwater and allowing it to seep into the ground. This This pavement technology creates more efficient land use by eliminating the need for retention.
IndoGuruji Indian Language Teacher
Authors: Rugge Shrishail , Metri Veer , Satpute Sujay , Nule Prathmesh , Devmore A. P.
Published: April 2023

Abstract: The IndoGuruji Indian Language Teacher application is a great application for anyone wanting to learn an Indian regional language. It provides an easy and convenient way to learn text from one language to another. The application is extremely user-friendly and can be used by anyone, regardless of their level of expertise. The Indian Language Teacher is an essential tool for anyone wanting to communicate in an Indian regional language. It is a revolutionary new application that makes learning Indian languages easy and fun. With its user-friendly interface and comprehensive language learning tools, the Indian Language Teacher is the perfect application for anyone interested in learning an Indian language. The IndoGuruji Application is the one and only kind to teach the Indian Language in an interactive way and also covers all the flaws of the other Indian Language Teaching application which is available in the market. The app contains lessons and quizzes to help users learn the basics of the Indian language of their choice.
The Moderating Effect of the Work Environment Cluster Type on the Relationship between Director's Emotional Leadership and Job Satisfaction of Child Care Teachers
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Hwang Hyuk , Moon Hyuk-Jun
Published: April 2023

Objectives The purpose of this study was to examine the Moderating Effect of working environment cluster analysis on the relationship between directors' emotional leadership and job satisfaction of child care teachers. Methods The participants in the study were 462 child care teachers in Seoul, Gyeonggi, Daejeon province, cluster analysis using the sub-scales of work environment was conducted. According to the cluster type, the significance was verified using Process macro 3.3 for moderating effect in the relationship between emotional leadership of the director and job satisfaction of child care teachers. Results First, there were 3 clusters according to infant care teacher’s work environment. Cluster 1 was named ‘working environment low-group’, Cluster 2 was named ‘working environment middle group’, and Cluster 3 was named working environment high-group’. Second, ‘working environment low-group’ demonstrated a significant moderating effect between directors' emotional leadership and job satisfaction. The low the level of working environments have become, the bigger conditional effect they have had. Conclusions The results of this study is meaningful in identifying characteristics of the working environment of infant care teachers, and providing information that can suggest ways to actively influence job satisfaction.
A Study on Personality Education through Arts-integrated Dance Activities for Children with Disabilities
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Oh Hyun-Ju
Published: April 2023

Objectives This study aims to explore how personality education is practiced in arts-integrated dance activities for children with disabilities and how it affects the personality of children with disabilities. Methods To this end, 15 rounds of personality education through art integrated dance activities were provided for a total of 6 people with disabilities, 1 class facilitator and 1 volunteer once a week at the Bitna Disabled Welfare Center over the period between August 6, 2021 and November 30, 2021. Class journals, in-depth interviews, and expert meetings were employed to collect data, and case analysis and inductive category analysis were conducted for data analysis. Results The personality aspect of art-integrated dance activities had a major impact on children with disabilities in two aspects. First, it was found to have an effect on the good heart and bright expression of benvolence and propriety (harmony and harmony, intimacy and group bond, joy), and second, to have an impact on the wonderful behavior and good attitude of righteousness and wisdom (promise, concentration, praise, courage, creativity). Conclusions Children with disabilities had many difficulties because they lacked the ability to accept and understand other people's emotions, responsibility, and attention. However, as they experienced arts- integrated dance activities, they clearly discovered themselves, and learned about good minds such as communication and empathy, bright expressions, wonderful behaviors, and good attitudes. Children with disabilities can grow into good people through the personality contained in art integrated dance activities, and they can feel the joy of being with others as members of society. Therefore, arts- integrated dance activities will foster personality, personality education will be conducted through arts, and it will help achieve all purposes for the growth of disabled children.
A study on learning experience of graduate students in a metaverse environment: From Deleuze's perspective of ‘-becoming’
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Oh Heejung , Park Eunsil , You Youngmahn
Published: April 2023

Objectives The purpose of this study was to examine the learner's experience and meaning in a metaverse environment from a Deleuze's perspective. These studies will be able to present the direction of open learning in which learners can move toward the existence of independent ‘-being’ and provide basic data for the study of the educational use and effectiveness of metaverse that have recently emerged. Methods To this end, an in-depth interview was conducted with four graduate students of H University in Seoul by organizing a questionnaire related to their experience in the metaverse. As a result of the in-depth interview, Creswell (2009)'s spiral analysis method was used. Results The research results are as follows. First, becoming a constantly changing existence facing a new and unfamiliar space, second, becoming a true existence that reveals subjectivity and creates differences, and third, becoming a existence that constantly escapes and creates another world. Conclusions Following at the derived results, it was found that the space called metaverse could provide learners with an opportunity to face various symbols and provide various educational experiences to become the subject of change and creation. In addition, as a follow-up study, it is necessary to critically look at the standardized curriculum aspect in the educational field, beyond research on whether the learner's experience on metaverse has an educational effect.