bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study of Management of Subtrochanteric Fractures Treated by Proximal Femoral Nail - A Prospective Study
Authors: Dasari Venkateswara Rao , Chinta Shyam Kumar , CNS Mounika , Azari Prathyusha
Published: February 2022

BACKGROUND The proximal femur nail (PFN) is one of many intramedullary nails that have been designed for the early mobilisation and secure fixation of subtrochanteric fractures. METHODS We conducted a prospective study at our institute between November 2018 and November 2020 on a hundred patients who had high subtrochanteric fractures and were treated with proximal femoral nailing. Ninety-five patients had fracture fragments reduced to within a few millimetres of their anatomical size, whereas five needed limited open reduction. RESULTS In the current study, nine (7.76%) of the cases had superficial infections; no deep infections were observed. In five cases (5.76%), we found an anti-rotational screw cut-off. Three (4.75 percent) of the patients had shaft fractures with nail breaking. In the present series, the mean modified Harris Hip Score was 81.24, ranging from 100 to 29. Regardless of fracture kind, all of the patients between the ages of 20 and 30 achieved good results (80.77 percent) in this study. Patients in the older age group had comparatively bad results (19.33%), with 50 percent (5) having poor results and five (50%) having good to fair results. CONCLUSIONS Patients in the older age groups did not have a good outcome in this series. These findings suggest that to reduce problems, a meticulous surgical technique and adjustments tailored to the individual fracture pattern are required. The advantages of the high rotational stability and unreamed insertion method of the head-neck fragment, as well as the potential of static or dynamic distal locking, are emphasized in osteosynthesis of the proximal femoral nail. KEY WORDS Proximal Femur Nail, Subtrochanteric Fractures
Peripartum Cardiomyopathy
Authors: J. John Vinoj , M. Vigneshwaran
Published: February 2022

BACKGROUND Peripartum cardiomyopathy is a rare, dilated cardiomyopathy with systolic dysfunction that occurs in the late pregnancy or more commonly in the early postpartum period. Risk factors include pre-eclampsia, advanced maternal age, multiple gestation. Although the complete pathogenesis is unclear, researches over the past few years suggest the importance of vasculo-hormonal pathways in women with underlying susceptibility and sarcomere gene mutation. Most of the patients will recover with adequate systolic function, although very few may go on to chronic cardiomyopathy. Other potential complications include thromboembolism and arrhythmias. METHODS This is a prospective study conducted at Kanyakumari Government Medical College between May 2019 and May 2021. 10 cases were observed and followed up. ANC cases with acute heart failure and no history of previous heart diseases were included in the study. Patients with known heart diseases were excluded from the study. RESULTS 10 cases of ANC cases were diagnosed with peripartum cardiomyopathy with half of them having comorbidity and others were comorbid free. Diagnosis was confirmed with echocardiography and all the patients recovered with medical management. CONCLUSIONS Though peripartum cardiomyopathy is a rare occurring event, incidence of 10 cases in a period of 2 years highlights the need for us to be aware of this peripartum cardiac event and have it as a differential diagnosis in the situational setting at the back of the mind. Since this is a serious medical condition that affects pregnant women, prompt and timely medical intervention will save the patient from serious life-threatening complications. KEY WORDS Peripartum Cardiomyopathy, Pregnancy, Heart Disease, Dyspnoea in Pregnancy.
Uma experiência interrompida: o Colégio Integrado do Centro Pedagógico da Universidade Federal de Minas Gerais (1971)
Authors: Santos Alessandra Soares
Published: February 2022

O artigo aborda a experiência do Colégio Integrado do Centro Pedagógico da UFMG, realizada em 1971, a partir de uma perspectiva que buscou compreender tanto a dinâmica interna desta instituição escolar, quanto sua relação com a política educacional estabelecida pela ditadura civil-militar. O Colégio Integrado propôs uma estrutura e um currículo próprio que pretendeu representar uma das possibilidades mais arrojadas de ensino e, ao mesmo tempo, se adequar às novas demandas da reforma do ensino de 1º e 2º graus que estava em discussão em nível federal e que viria a ser oficializada no ano seguinte. Entretanto, esta experiência foi interrompida pela proposta de profissionalização obrigatória prevista na lei e também pelas circunstâncias internas à universidade. Concluímos que esta experiência se juntou a outras do mesmo período que, pretendendo inovar o ensino secundário, não foi capaz de superar os entraves de um sistema educacional conservador e pragmático.
“Ciclo de Debates sobre Educação Brasileira Contemporânea”: posições conflitantes acerca da educação na Universidade Federal da Paraíba (1979)
Authors: Machado Charliton José dos Santos , Nunes Maria Lucia da Silva , Machado Aline Maria Batista
Published: February 2022

A partir das noções teórico-metodológicas da Nova História Cultural, especialmente da História do Tempo Presente, objetivou-se analisar as principais ideias, comunicações e intervenções, apresentadas no “Ciclo de Debates sobre a Educação Brasileira Contemporânea”, realizado em 1979, na Universidade Federal da Paraíba. Almejou-se também resgatar a importância desse evento que, em plena ditadura militar, confrontava os ideais antidemocráticos do período, e destacar o papel exercido pela UFPB e o Centro de Educação, no contexto em que já se prenunciavam a defesa da anistia e abertura política. A fonte principal deste estudo foram os Anais do evento, de 1981. Os debates desenvolvidos contemplaram da educação básica à educação superior, e sob uma ótica crítica analisavam os obstáculos e os dilemas da educação brasileira em todas as suas modalidades, mas também buscavam apontar alternativas e mudanças. Portanto, entende-se que o evento assegurou um lugar de protagonismo à UFPB e ao CE naquela conjuntura.
Contribuições da literatura para a História da Educação
Authors: Lima Ana Laura Godinho , Menezes Roni Cleber Dias de
Published: February 2022

Este dossiê parte da premissa de que a literatura tem contribuições preciosas a oferecer para a história da educação. À partida, no que concerne mais de perto ao domínio metodológico, é notável a dilatação - acompanhada em seu aspecto quantitativo pelo que se refere também à diversidade - das fontes e dos objetos propiciados pelas obras literárias para a interpelação do passado educativo realizada pelo historiador. A exploração dessa potencialidade está em íntima consonância com o movimento de renovação historiográfica vindo à tona nas últimas décadas do século XX no terreno da história tout court e que chega um pouco mais tarde ao domínio da história da educação. Caracterizada em grande medida pelo protagonismo das temáticas de matiz sociocultural, as apropriações realizadas no interior desta última apontam outrossim para novos problemas, os quais terminam por provocar novas abordagens, intensificando o diálogo da história da educação com outras áreas das ciências humanas, especialmente em torno da mobilização de novos repertórios teóricos.
Efficiency of Zakat Fund Payment through "E-Muzakki" in Industrial Revolution 4.0
Authors: Maesaroh Indah , Fauziyah Anisa Nurul , Ishak Ishak
Published: February 2022

Indonesia is one of the countries with the most Muslim population in the world. Around 80% of the total population of Indonesia is Muslim. So it is not surprising, that Islam and various kinds of Islam exist in Indonesia. Apart from that, Islam there is known as Islam which is quite advanced and developing as well as being very tolerant of other religions whose numbers are also not small. In this case, Indonesia is indeed not an Islamic state, but it does not rule out the possibility that zakat in Indonesia can be far more developed than other countries. Zakat certainly has a very important role for the economy in Indonesia, this is certainly also supported by the majority Muslim population in Indonesia. In writing this paper, the author uses the type of library research, in which problems are described based on data contained in literature or documents. Then analyzed further to be drawn a conclusion. it can be concluded that related to this research is the concept of zakat fund payment theory can be applied as a platform to make zakat payments effectively and efficiently for millennials. E-Muzakki is a platform or application that makes it easy for muzakki who have funds to reach their nishob to pay zakat.
Trust on Sharia M-Banking: Evidance on Milenials Generations
Authors: Safitri Novita , Anggraini Wahyu
Published: February 2022

This study aims to examine the trust of millennial generation in the role of sharia mobile banking in the ease of solving their financial problems. The increased use of smartphones has made the banking industry provide mobile banking services to facilitate and increase customer productivity. The level of trust in sharia mobile banking is measured using the Technology Acceptance Model (TAM). Based on TAM, trust is determined by Perceived Easy of Use (PEoU), Perceived Usefulness (PU), Attitude to Product (ATP), and Intention to Use (ITU). This study uses an independent survey, with a total sample of 330 sharia mobile banking users spread throughout Indonesia. Data analysis techniques used in this study used SB-SEM (Covariance Based-Structural Equation Modeling) with AMOS software. The results showed that PEoU had a positive effect on PU, PEoU had a positive effect on ATP, PU had a positive effect on ATP, ATP had a positive effect on ITU, and ITU had a positive effect on Trust. Overall millennial generation has a high level of trust in sharia mobile banking, because sharia mobile banking is easy to use and makes it easy to solve their financial problems.
Change Management Strategy in Islamic Organizations
Authors: Fauza Dhiya Rahmi , Rahman Ahmad Arif
Published: February 2022

Change management is a process of managing change in order to make the best use of it by applying the knowledge, strategies, tools, and resources needed to achieve certain goals. Change management is aimed at providing the business solutions needed successfully in an organized manner and with methods through managing the impact of change on the people involved in it. The purpose of this study is to determine the change management strategies and the causes of making changes so that the changes can be utilized as well as possible. This study uses a positive post approach with the method of collecting literature study data (literature review) of several previous journals that contain research data on change management in English and Indonesian. In this study discusses the strategies and causes of managing change in organizations.
Comparative Analysis of Factors Affecting the Underpricing Level of Sharia and Non Sharia Stocks at the time of Initial Public Offering
Authors: Hidayah Lia , Sunarsih Sunarsih
Published: February 2022

Underpricing is a condition where the stock price of a company when conducting an Initial Public Offering (IPO) is below the stock price when it is on secondary market. In Indonesia, stocks are divided into two types, namely Sharia stock and non Sharia stock. This study aims to determine the effect of underwriter reputation, investment risk, profitability, financial laverage, and company size on the level of underpricing of Sharia stock and non Sharia stock. The sampling technique used was purposive sampling. The analytical method used is linear multiple regression with the type of cross section data. The results of the study found that there are differences that effect  the underpricing of Sharia stock and non Sharia stock. In Sharia stock, underpricing is only influenced by financial laverage, while in non Sharia stock underpricing is influenced by investment risk and company size. This study provides an overview to investors who have the aim of investing in companies that are IPOs for profit so that they carefully consider the influence of underwriter variables, investment risk, company size, financial laverage, and profitability. For companies, this research provides an overview to companies in order to make the right decisions in offering optimal stock prices. And for further researchers,
The Effect of Quality, Image and Price on Repurchase Decisions
Authors: Antaka Tridiar , Iklima Syanaz
Published: February 2022

This research aimed to determine whether there is the influence of product quality, brand image and price towards the repurchase decision of smartphone xiaomi. This research uses quantitative method. The number of samples in this research was 100, this research used purposive sampling technique to determine the samples. Method of completion of data used in this research were a questionare and google form. Result of t test shows significant influence product quality variable on decision making with tcount 3.111 ≥ t-table 1.660. Significant influence brand image on decision making with tcount 3.153 ≥ t-table 1.660. Significant influence price on decision making with tcount 6.980 ≥ ttable 1,660. Product quality, brand image and price variables simultaneously have an effect of repurchase decision.
Eliminasi Cairan dengan Target Balans Cairan Negatif pada Pasien Bedah Sesar dengan Gagal Jantung, Penyakit Jantung Kanan, Hipertensi Pulmonal dan Pasca Repair Katup Mitral
Authors: Napitu Sabar Hamonangan Victorianus , Madjid Amir S , Muljono Indro
Published: February 2022

Latar Belakang: Kehamilan dengan permasalahan jantung merupakan sebuah tantangan dalam pengelolaan pasien-pasien kritis. Right heart disease (RHD) yang menyebabkan mitral regurgitation (MR) dan selanjutnya diikuti oleh congestive heart failure (CHF) yang terjadi pada ibu hamil menyebabkan fluid overload dengan segala konsekuensinya. Fluid removal dengan target balans cairan negatif merupakan strategi pengelolaan pada kondisi tersebut.Kasus: Untuk kasus ini, fluid removal dilakukan dengan pemberian diuretik (Furosemide) sejak hari I sampai dengan IV dengan dosis 2-5 mg/jam secara titrasi. Panduan fluid removal yang digunakan adalah kondisi klinis pasien secara umum, ditambah dengan parameter seperti: tekanan darah, heart rate, urine output, balans cairan kumulatif, tingkat kebutuhan akan obat-obat penopang hemodinamik, rasio hemoglobin/hematokrit, ureum, kreatinin, laktat, dan BE (parameter makro dan mikro dinamik).Pembahasan: Panduan baku tentang fluid removal baik dalam hal volume cairan yang ditarik, durasi, dan timing untuk memulai dan mengakhiri belum ada.Kesimpulan: Diperlukan monitoring ketat untuk mencapai balans cairan negatif tanpa menimbulkan efek samping.
Chess movies między ludologią a historią wizualną – wprowadzenie do zagadnienia. Od Gorączki szachowej (1925) po Gambit królowej (2020)
Authors: Szymala Jacek
Published: February 2022

Celem artykułu jest sklasyfikowanie tzw. chess movies – filmów szachowych, o szachach i szachistach. W tekście wymieniono i scharakteryzowano wybrane tytuły spośród 83 ujętych w zestawieniu filmograficznym. Autor proponuje interdyscyplinarne ujęcie badawcze łączące elementy ludologii i historii wizualnej. Każdy film mówi coś o czasie, w którym powstał, w tym o historii szachów i ich postrzeganiu w danym okresie historycznym
No association of natural killer cell number and function in peripheral blood with overweight/obesity and metabolic syndrome in a cohort of young women
Authors: Keilen Julia , Gar Christina , Rottenkolber Marietta , Fueessl Louise U. , Joseph Anna T. , Draenert Rika , Seissler Jochen , Lechner Andreas
Published: February 2022

Aim

To reexamine the associations of NK cell number and function in the peripheral blood with overweight/obesity and the metabolic syndrome in a large, well‐phenotyped human cohort.

Methods

Cross‐sectional analysis of 273 women in the PPSDiab Study; measurement of absolute and relative number of NK cells in peripheral blood, and of functional parameters CD69 positivity and cytotoxicity against K562 cells; group comparison of NK cell characteristics between lean, overweight, and obese participants, as well as metabolic syndrome scores of 0, 1, 2, and ≥3; Spearman correlation analyses to clinical parameters related to the metabolic syndrome.

Results

We found no differences in NK cell number and function between lean, overweight, and obese women (relative NK cell number (median (Q1–Q3), [%]) 5.1(2.6–9.4) vs. 4.8 (2.9–8.4) vs. 3.8 (1.7–7.8), p = 0.187; absolute NK cell number [106/L]: 86.9 (44.6–188.8) vs. 92.6 (52.5–154.6) vs. 85.9 (44–153.8), p = 0.632; CD69+ [%]: 27.2 (12.9–44.3) vs. 37.6 (13.2–52.8) vs. 33.6 (16.3–45), p = 0.136; cytotoxicity [%]: 11.0 (7.1–14.5) vs. 8.5 (6.4–13.2) vs. 11.3 (8.7–14.2), p = 0.094), as well as between different metabolic syndrome scores. Nonesterified fatty acids correlated with absolute and relative NK cell number and cytotoxicity (ρ [p‐value]: 0.142 [0.021], 0.119 [0.049], and 0.131 [0.035], respectively). Relative NK cell number further correlated with high‐density lipoprotein cholesterol (0.144 [0.018]) and cytotoxicity with 2 h glucose in oral glucose tolerance testing (0.132 [0.034]). CD69 positivity correlated with body fat (0.141 [0.021]), triglycerides (0.129 [0.033]), and plasma leptin (0.155 [0.010]). After correction for multiple testing, none of the associations remained significant.

Conclusion

In the present study, we observed no associations of NK cell number and function in the peripheral blood with overweight/obesity and the metabolic syndrome. Extreme phenotypes of obesity and the metabolic syndrome might have caused differing results in previous studies. Further analyses with a focus on compartments other than peripheral blood may help to clarify the relation between NK cells and metabolic diseases.
The glucose lowering effects of CL 316,243 dissipate with repeated use and are rescued by cilostamide
Authors: Medak Kyle D. , McKie Greg L. , Shamshoum Hesham , Seguin Ian , Wright David C.
Published: February 2022

Repeated activation of the beta 3 adrenergic receptor (β3AR) with the agonist CL 316,243 (CL) results in remodeling of white adipose tissue (WAT) characterized by increased mitochondrial enzymes and expression of uncoupling protein 1 (UCP1). β3AR activation also has profound acute metabolic effects including rapidly decreasing blood glucose, secondary to fatty acid‐induced increases in insulin, and increasing energy expenditure. The acute (single dose) effects of β3AR activation have largely been examined in treatment naive animals and under room temperature housing conditions. The current study examined if repeated CL treatment would lead to an attenuation of acute metabolic effects of CL treatment under thermoneutral housing conditions and if this could be rescued with cilostamide, a phosphodiesterase inhibitor. We provide evidence demonstrating that the acute effects of CL to increase serum fatty acids and insulin and reduce blood glucose, but not increases in energy expenditure, are attenuated in mice following repeated treatment with CL. This occurs in parallel with reductions in indices of protein kinase A signaling in WAT including the phosphorylation of hormone sensitive lipase. The findings of attenuated serum fatty acid, insulin, and blood glucose responses were confirmed in both high‐fat fed and UCP1−/− mice repeatedly treated with CL. Desensitization to CL in mice was rescued by cilostamide. Herein, we provide evidence that the glucose lowering, but not thermogenesis inducing, effects of CL are attenuated with repeated treatment and can be rescued by cilostamide. The findings of this study point toward novel adjunct treatment approaches that could be used to maximize therapeutic, glucose lowering effects of β3AR agonists.
Linear recurrent relations, power series distributions, and generalized allocation scheme
Authors: Timashev Aleksandr N.
Published: February 2022

We consider distributions of the power series type determined by the generating functions of sequences satisfying linear recurrence relations with nonnegative coefficients. These functions are represented by power series with positive radius of convergence. An integral limit theorem is proved on the convergence of such distributions to the exponential distribution. For the generalized allocation scheme generated by these linear relations a local normal theorem for the total number of components is proved. As a consequence of more general results of the author, a limit theorem is stated containing sufficient conditions under which the distributions of the number of components having a given volume converge to the Poisson distribution.
Enabling data-centric AI through data quality management and data literacy
Authors: Abedjan Ziawasch
Published: February 2022

Data is being produced at an intractable pace. At the same time, there is an insatiable interest in using such data for use cases that span all imaginable domains, including health, climate, business, and gaming. Beyond the novel socio-technical challenges that surround data-driven innovations, there are still open data processing challenges that impede the usability of data-driven techniques. It is commonly acknowledged that overcoming heterogeneity of data with regard to syntax and semantics to combine various sources for a common goal is a major bottleneck. Furthermore, the quality of such data is always under question as the data science pipelines today are highly ad-hoc and without the necessary care for provenance. Finally, quality criteria that go beyond the syntactical and semantic correctness of individual values but also incorporate population-level constraints, such as equal parity and opportunity with regard to protected groups, play a more and more important role in this process. Traditional research on data integration was focused on post-merger integration of companies, where customer or product databases had to be integrated. While this is often hard enough, today the challenges aggravate because of the fact that more stakeholders are using data analytics tools to derive domain-specific insights. I call this phenomenon the democratization of data science, a process, which is both challenging and necessary. Novel systems need to be user-friendly in a way that not only trained database admins can handle them but also less computer science savvy stakeholders. Thus, our research focuses on scalable example-driven techniques for data preparation and curation. Furthermore, we believe that it is important to educate the breadth of society on implications of a data-driven world and actively promote the concept of data literacy as a fundamental competence.
The role of acupuncture for myofascial pain syndrome (MPS) in interventional pain management
Authors: Fredy Diana Marsha , Harpin Darwin , Mihardja Hasan
Published: February 2022

Objectives

The aim of this literature review is to describe the role of acupuncture for myofascial pain syndrome in interventional pain management.

Content

Myofascial pain syndrome (MPS) can be found at all ages. Approximately 30.0–93.0% of patients with musculoskeletal pain have MPS. Unsuccessful treatment can lead to dysfunction, disability, and a cost burden. We conducted a search of studies published in Google Scholar and PubMed databases from 2016 to 2021.

Acupuncture, combined with other therapies, is effective in reducing pain and improving physical function. Acupuncture can enhance endogenous opioids such as endorphins to relieve pain and enhance the healing process.

Outlook

Acupuncture could be considered as one of nonpharmacological options in Interventional Pain Management for MPS. Interventions with acupuncture are safe and have minimal side effects when performed by a trained and competent practitioner.
Assessing the United States’ most frequently asked questions about osteopathic medicine, osteopathic education, and osteopathic manipulative treatment
Authors: Sajjadi Nicholas B. , Ottwell Ryan , Shepard Samuel , Bray Natasha , Dyer Robin , Wilson Jennifer , Vassar Matt , Hartwell Micah
Published: February 2022

Context

Osteopathic medicine in the United States continues to produce a substantial number of physicians and medical educators. However, recently popularized misconceptions about osteopathic medical practice, education, and manual therapy suggest an unsettling prevalence of inaccurate beliefs held by the public. The public often searches the internet to find out information about osteopathic medicine, but the content of questions and the transparency of the resulting information is unknown.

Objectives

We sought to explore frequently asked questions (FAQs) generated by Google to assess commonly searched questions about the osteopathic profession and to determine the level of information transparency associated with resulting sources.

Methods

On June 16, 2021, we searched Google for three terms: “osteopathic medicine,” “doctor of osteopathic medicine,” and “DO,” until a minimum of 100 FAQs and their answer links were extracted from each search. After excluding irrelevant FAQs, we used Rothwell’s Classification of Questions to categorize the FAQs. We then used the Journal of the American Medical Association’s Benchmark Criteria to assess information transparency for each corresponding answer source provided by Google. The answer sources were screened for the inappropriate use of “osteopathy” in place of “osteopathic medicine” and for “osteopath” in place of “DO,” “Doctor of Osteopathic Medicine,” or “Osteopathic Physician.” We performed statistical tests to ascertain the differences in information transparency between osteopathic and nonosteopathic information sources.

Results

Our Google search revealed 110 unique FAQs about osteopathic medicine. The majority of FAQs were classified as fact-based (82/110; 74.55%), nearly half of which (45.12%) were related to the medical practicing privileges of DOs. The FAQs were most commonly answered by academic institutions (44/110, 40.0%). Nearly half (49.09%) of the linked answer sources were deemed inadequate by JAMA benchmark criteria. Of the 110 linked answer sources, 19 (17.27%) misused either osteopathy, osteopath, or both to describe osteopathic physicians. Only 30 sources were linked to US-based osteopathic organizations. Osteopathic organizations were statistically less likely to meet high-transparency criteria than nonosteopathic organizations (p=0.002).

Conclusions

Our study shows that the US public may be unsure about the physician status of DOs, which may prevent securing the professional identity of osteopathic physicians in the eyes of the public. Osteopathic organizations should tailor awareness campaigns toward addressing the common misconceptions revealed by our study. Osteopathic organizations should use transparency criteria as a rubric when publishing information to enhance transparency.
A pan-cancer analysis of the oncogenic role of Holliday junction recognition protein in human tumors
Authors: Su Rong , Huang Hechen , Gao Xingxing , Zhou Yuan , Yin Shengyong , Xie Haiyang , Zhou Lin , Zheng Shusen
Published: February 2022

Although cell-based or animal-based research evidence support the association of Holliday junction recognition protein (HJURP) with cancers, no pan-cancer investigation has been reported. The datasets of Gene Expression Omnibus database along with The Cancer Genome Atlas project were used to evaluate the expression of HJURP in various types of tumors. HJURP is overexpressed in a considerable number of cancers, and some changes in DNA methylation and genetic alterations are discovered in some types of tumors, such as kidney-related and adrenal gland-related tumors. Based on PrognoScan and gene expression profiling interactive analysis (GEPIA), the elevated expression of HJURP worsened the survival time of individuals with cancer. The biological general repository for interaction datasets (BioGRID) and The database for annotation, visualization and integrated discovery (DAVID) were used to establish the functional molecular network. It revealed that the cell cycle and p53 signaling pathway are the key molecular mechanisms that HJURP promotes carcinogenesis. The nomograms between HJURP and clinical pathological factors based on the Cox proportional hazards model showed a good prognostic performance in kidney carcinoma, hepatocellular carcinoma, and lung adenocarcinoma. Our first pan-cancer study provides a relatively profound insights into the oncogenic roles of HJURP across different tumors.
Radiation increases COL1A1, COL3A1, and COL1A2 expression in breast cancer
Authors: Yao Guorong , Zhao Kaiyue , Bao Kaikai , Li Jing
Published: February 2022

Background

Radiotherapy-associated secondary cancer is an important issue for the treatment of breast cancer (BCa). This study aimed to investigate the molecular mechanism and genetic risk factors for radiation-associated secondary diseases in BCa.

Methods

The differentially expressed genes (DEGs) between preradiation and postradiation BCa samples in the GSE65505 dataset were obtained. The pathways related to the radiation-associated DEGs in the protein–protein interaction (PPI) network modules were identified. miRNAs targeted to the key genes in the PPI network were identified, and their association with BCa prognosis was analyzed.

Results

A total of 136 radiation-associated DEGs preradiation and postradiation BCa samples were screened out. The PPI network consisted of a significant module that consisted of 21 upregulated DEGs that were associated with “hsa04512: ECM–receptor interaction,” “hsa04151: PI3K-Akt signaling pathway,” and “hsa04115: p53 signaling pathway.” Sixteen DEGs, including three collagen genes collagen type I alpha 1 chain (COL1A1), COL3A1, and COL1A2, were enriched in 17 radiation-associated pathways. The three genes were upregulated in BCa tissues compared with controls and were also elevated by radiation. They were targeted by hsa-miR-29a/c, and the expression levels of hsa-miR-29a/c were associated with a poor prognosis of BCa.

Conclusions

The upregulation of COL1A1, COL3A1, and COL1A2 might be genetic risk factors for radiation-associated secondary diseases in BCa.
A large-scale single-mode array laser based on a topological edge mode
Authors: Ishida Natsuko , Ota Yasutomo , Lin Wenbo , Byrnes Tim , Arakawa Yasuhiko , Iwamoto Satoshi
Published: February 2022

Topological lasers have been intensively investigated as a strong candidate for robust single-mode lasers. A typical topological laser employs a single-mode topological edge state, which appears deterministically in a designed topological bandgap and exhibits robustness to disorder. These properties seem to be highly attractive in pursuit of high-power lasers capable of single mode operation. In this paper, we theoretically analyze a large-scale single-mode laser based on a topological edge state. We consider a sizable array laser consisting of a few hundreds of site resonators, which support a single topological edge mode broadly distributed among the resonators. We build a basic model describing the laser using the tight binding approximation and evaluate the stability of single mode lasing based on the threshold gain difference Δα between the first-lasing edge mode and the second-lasing competing bulk mode. Our calculations demonstrate that stronger couplings between the cavities and lower losses are advantageous for achieving stable operation of the device. When assuming an average coupling of 100 cm−1 between site resonators and other realistic parameters, the threshold gain difference Δα can reach about 2 cm−1, which would be sufficient for stable single mode lasing using a conventional semiconductor laser architecture. We also consider the effects of possible disorders and long-range interactions to assess the robustness of the laser under non-ideal situations. These results lay the groundwork for developing single-mode high-power topological lasers.
The crystal structure of [(2,2′-bipyridine-k2
N,N)-bis(6-phenylpyridine-2-carboxylate-k2
N,O)copper(II)], C34H24N4O4Cu
Authors: Yi-Min Feng , Xi-Shi Tai , Yu-Pei Xia
Published: February 2022

C34H24N4O4Cu, monoclinic, C2/c (no. 15), a = 17.2931(15) Å, b = 10.3584(5) Å, c = 17.5641(16) Å, β = 120.180(12)°, V = 2719.8(5) Å3, Z = 4, R

gt
(F) = 0.0282, wR
ref(F
2) = 0.0681, T = 199.99(10) K.
Foliar application of boron positively affects the growth, yield, and oil content of sesame (Sesamum indicum L.)
Authors: Khuong Nguyen Quoc , Thuc Le Vinh , Tran Nguyen Thi Bich , Huu Tran Ngoc , Sakagami Jun-Ichi
Published: February 2022

The objective of this study was to determine the optimal concentration of boron (B) to obtain the highest growth, yield, and oil content of black sesame. A field experiment was conducted in a completely randomized block design with five treatments and five replications. Treatments included foliar application of B at five rates: control, 50, 100, 150, and 200 mg L−1 at 25 and 35 days after sowing. Results showed that spraying B on leaves increased sesame growth in terms of plant height, number of leaves, and chlorophyll content. Moreover, spraying B increased yield components including the number of pods; the highest pods per plant was 46.2 in the B application treatment with 150 mg L−1 compared to the control with 27.2 pods per plant. The grain yield of the B spray treatment produced 1.10–1.32 t ha−1, with the highest yield at the dose of 150 mg L−1 and the lowest yield at no B spray treatment. Spraying B on leaves at optimal concentration also increased the oil content in seeds up to 5.3% compared to the control treatment. The findings of the study suggest that foliar B application with 150 mg L−1 increases the growth, fruit set, seed yield, and oil content in sesame.
On numerical computation of sensitivity of response functions to system inputs in variational data assimilation problems
Authors: Shutyaev Victor , Ha Tran Thu , Le Dimet Francois-Xavier , Hoang Hong Son , Phong Nguyen Hong
Published: February 2022

Prediction of pollution in water flow is a very important task. To this end, it is imperative to be able to define the uncertainty in a model prediction. This is the purpose of sensitivity analysis whose role is to identify what uncertainty in the model outputs is attributable to the model inputs (parameters in this case). Traditionally, this is achieved by running the model perturbed by many random samples in the parameter space to determine their impact on the model outputs. It provides information on how much of the output variance is controlled by each parameter of the inputs.

The theoretical results related to the procedure based adjoint approach for computing a sensitivity of the response function (RF) to changes in the input source are presented in the paper. It is shown that this approach allows to compute, by one single integration of the adjoint equation over a given time interval, a sensitivity of the RF to any source located in the domain of interest. The proposed approach is applied to the 2D Saint-Venant flow equations for modelling the water pollution problem. A numerical experiment is formulated and implemented for the Thanh Nhan Lake in Hanoi for studying a sensitivity of some RF to observations. The numerical model is constructed by applying the well-known finite-volume method. Two appropriate optimization problems are introduced and solved on the basis of the BFGS algorithm. The numerical results show the efficiency of the proposed method and confirm the theoretical findings.
Conflicted landscapes: The Kall Trail. Monitoring transformations of a Second World War heritage site using UAV-lidar remote sensing and ground truthing
Authors: Adam Mirjam , Storch Marcel , Rass Christoph A.
Published: February 2022

The transformation of Second World War heritage sites is a common challenge for today's memory culture. In this project, we combine ground truthing with drone-based, high-resolution laser scanning to document recent anthropogenically and environmentally caused transformation processes, and to raise public awareness of the importance of the ever-changing conflict landscape of the ‘Huertgen Forest’.
Design of Wireless Sensor Network Data Acquisition System via Health Sensor Based on Symmetric Encryption Algorithm
Authors: Xuan Chunqing
Published: February 2022

In order to improve the data collection effect of the wireless sensor network, a data collection system based on symmetric encryption algorithm is designed via health sensor. Upload the received data to the host via RS-232 to get the working mode and clock activity. The data acquisition circuit is designed with MSP430 module. The MapReduce programming model is used to complete data collection, a symmetric encryption algorithm is introduced, and a range data encryption query scheme with privacy protection function is designed. Apply it to the node data of the wireless sensor network to realize the secure data collection of the wireless sensor network. Experimental results show that the system has the advantages of high efficiency, large amount of data collection, and high residual energy of sensor network nodes.
The effect of two different types of removable partial dentures on chewing activity and muscle efficiency.
Authors:   Hawler Medical University, Mohammed Banu , Hasan Rizgar
Published: February 2022

Background and objectives: Cobalt chromium removable partial denture has been in use for years and despite of the advantages that cobalt chromium provides, it has many disad‐ vantages. In the recent years flexible removable partial denture has been introduced to dentistry with many advantages over cobalt chromium removable partial denture . The purpose of this study was to evaluate the effect of cobalt chromium and flexible removable partial denture on chewing activity and muscle efficiency. Methods: Ten patients were selected, all of them had completely edentulous maxilla and Kennedy Class I partially edentulous lower arch. eight male and two females with their ages ranging from 45 to 60 years. For each patient, an upper complete denture and two lower removable partial dentures (cobalt chromium and flexible) were constructed. Once the dentures were completed, muscle efficiency with the use of Electromyography and chew‐ ing activity by sieving method was performed in scheduled visits. Statistical analysis of data was achieved by means of (SPSS 25). And performing (independent sample T test, one‐way anova test, and multiple comparison Tukey test). Results: The chewing activity test, revealed a statistically significant difference (P< 0.05) between first and fourth visit concerning the flexible partial denture and improvement of chewing, for the cobalt chromium removable partial denture although there was improve‐ ment of chewing but it was not significant. Regarding the muscle efficiency test, this test revealed that there was no major significance between flexible and cobalt chromium re‐ movable partial denture and they are almost the same, but we can notice improvements of muscular efficiency specially in masseter muscle. Conclusions: Within the limitations of this study, it has been concluded that the muscle efficiency is improved within one month of insertion of both types of removable partial denture . Both flexible and cobalt chromium dentures increased muscle efficiency. Flexible removable partial denture increased chewing activity slightly better than cobalt chromium, while cobalt chromium was marginally better at chewing of hard food comparing to flexible denture.
Effect of bleaching materials and whitening mouth wash on surface roughness of two types of composite resin materials nanohybrid and nanofill: an In‐vitro Study.
Authors:   College of Dentistry-Hawler Medical University, Taher Manal , Aziz Nsar , Toma Intesar
Published: February 2022

Background and objective: Bleaching teeth is one of the effective, comparatively safe, aesthetic treatments in dentistry. Many systems are available now in clinical practice that has a peroxide mechanism. The purpose of this study was to evaluate the effect of three different bleaching system on the surface roughness of two different composite resin materials (nanohybride and nanofilled). Methods: A total of 60 samples of two types of composite resin were used (nanohybrid and nanofill), 30 samples for each material were prepared. The total samples then divided into six groups, ten samples for each group. Each group were analyzed and tested before exposing to bleaching system that considered as control, by using surface roughness (Ra) machine using atomic force microscopy. Three bleaching system then used, hydrogen peroxide 35% with laser and carbamide peroxide 10% three times each time for 15 min‐ utes while whitening mouth wash for 1 minute/ day for one month. After bleaching ended, the surface roughness of all the samples were re‐evaluated. Results:Whiting mouth wash thtcontaing peroxide bleaching agents showed a significant differences for the two composite materials(nano hybrid and nano filled). While for the another bleaching systems(hydrogen peroxide and carbamide peroxide) there is no significant differences Conclusion:Whiting mouth wash showed more surface roughness for the two materials when compared with the another bleaching materials and Increased surface roughness of composites as a result of bleaching appears to be dependent on the bleaching agent used as well as the composite material types.
The Efficacy of Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet laser in the removal of calcium hydroxide as intra canal medicament.
Authors:   College of Dentistry-Hawler Medical University, Sarhang Ranu , Zakareya Nawfal
Published: February 2022

Background and objectives: Removal of calcium hydroxide from root canal system is difficult, and its residuals left on the dentin walls reduce the penetration of root canal seal‐ ers into dentinal tubules, resulting in a possible increase of apical leakage. This study evalu‐ ated the efficiency of two different techniques including Erbium, Chromium: Yttrium, Scan‐ dium, Gallium, Garnet (Er, Cr: YSGG) laser activated irrigation and conventional method on the removal of calcium hydroxide Ca(OH)2. Methods: Twenty extracted single‐rooted teeth (upper second premolar, lower first and second premolars) with straight canals were prepared using ProTaper next rotary files up to size x5. The root canals were filled with calcium hydroxide and putted inside the incuba‐ tor for 1 week in 100% humidity. The samples divided in to two groups in the first one con‐ ventional irrigation was used while in the second group (Er, Cr: YSGG) laser activation irri‐ gation was used to remove Ca(OH)2. After removel of calcium hydroxide the roots were split in to two halves and viewed under stereo microscope then surface area of remained Ca(OH)2 was evaluated by Digimizer software. The data were analyzed statistically using one‐way ANOVA, least significant differences (LSD) and post hoc test 95% confidence level (P = 0.05). Results: The results of this study showed that the Er,Cr:YSGG laser activation irrigation was more powerful in the removal of Ca(OH)2 in the apical and middle part of the root as com‐ pared to conventional irrigation (P < 0.001) but, in the coronal part of the root there was no significant difference between both groups. Conclusion: Er,Cr:YSGG laser activated irrigation is significantly better removal of Ca(OH)2 in the apical and middle part of the root than conventional method, but did not provide complete removal of Ca(OH)2.
The Mother, the Mistress, and the Cover Girls
Authors: Blaylock Jennifer
Published: February 2022

When Ghana Television began in 1965, its first director, Shirley Graham Du Bois, explicitly devised it as an anticolonial and pan-African indigenous television system. Likely the first Black woman to head a national station, Graham Du Bois’ prominence, along with Genoveva Marais as head of programing, suggests that in its nascency Ghana Television was an exceptional place for women. Yet each woman’s relationship with Kwame Nkrumah, the first president of Ghana, shadowed their professional lives and legacies. Rumors situated them along female archetypes with a powerful man firmly at the center: Graham Du Bois as Nkrumah’s mother and Marais as his mistress. In this article, I argue that while Graham Du Bois and Marais’ media practice rarely addressed gender inequality specifically, their work as female broadcast leaders set a precedent for decolonial feminist futures even as the coloniality of gender extended into Ghana broadcasting during the independence period.
Decolonization, Disenchantment, and Arab Feminist Genealogies of Worldmaking
Authors: Saglier Viviane
Published: February 2022

This article analyzes the intersection of Third Worldist materialism and decolonial epistemologies in the Arab world by focusing on Lebanese filmmaker Heiny Srour’s decolonial feminist cinema in the transitional period of the 1970s to 1990s. It proposes to read Srour’s disenchanted critique of masculine Third World nationalisms and Western feminism as a practice of worldmaking that is grounded within colonial-patriarchal modernity. Using Srour’s own trajectory as an entry point into larger debates, the article reflects on what affiliation to third cinema means for crafting a cinema of liberation that reconfigures gender relations. Srour’s Leila and the Wolves (1984) exemplifies such an expansive praxis of third cinema by combining a feminist historiography that centers oral tales, myth, and genealogies with a commitment to the armed struggle. The article concludes that Srour’s decolonial feminist cinema functions as a pedagogical tool to build cross-gender coalitions necessary for the persistence of the anticolonial struggle.
On the Necessity of Bad Trans Objects
Authors: Keegan Cáel M.
Published: February 2022

Despite newly affirming images of transgender people proliferating across US visual media, there has been a concomitant rise in anti-transgender attitudes, transphobic legislation, and trans antagonistic violence. The assumption that more and better images of transgender people are key to achieving transgender equality strains under the weight of an emerging contradiction: “good” representation does not necessarily mean reduced social or political antagonism for transgender people. Rather, the emergence of “good” (i.e. marketable) trans media objects illustrates how the most politically challenging aspects of transgender identification are increasingly forced outside the horizon of representability. This essay turns away from “good” transgender representations and toward an archive of recently canceled “bad” transgender media objects, offering new assessments of their unexpected value. Claiming badness as a trans property that must be embraced to achieve sex and gender liberation, it defends bad trans objects as unrecognized sources of transformative potential.
Pascale Ferran
Authors: Dupont Joan
Published: February 2022

FQ contributing editor Joan Dupont continues her series on French women directors with a rare interview with Pascale Ferran, whose debut feature film, Petits arrangements avec la mort (Coming to Terms with the Dead, 1994), won the Caméra d’Or at Cannes. Dupont surveys the ups and downs of Ferran’s subsequent career, which includes the celebrated Lady Chatterley (2006) along with lesser-known films such as L’âge des possibles (The Age of Potential, 1996) and the more recent Bird People (2014).
Identity Remakes in and out of Time
Authors: Wanzo Rebecca
Published: February 2022

Film Quarterly columnist Rebecca Wanzo reads Hagai Levi’s remake of Ingmar Bergman’s Scenes from a Marriage as a case study for ongoing debates about remakes. Noting the particular scorn a remake can be subject to when racial or gender identities are changed or updated, she suggests that Levi’s Scenes is a feminist update that also illustrates how genre can get in the way of more progressive renderings of gender roles, revealing instead the intransigence of heteronormative gender performance.