bluuebunny/crossref_metadata_2025 huggingface dataset:
Alkaline phospatase activity in plasma of pregnant chagasic patients
Authors: Sartori María José , Lin Susana , Fretes Ricardo , Ruíz Moreno Lidia , Goldemberg Lía , P de Fabro Sofía
Published: September 2024

lite linetic properties of plasma placental alLaline phosphauase patients \vith Chagas' disease vere siudied. When Cl.Mc vas used as auivatorthe sanie mercaSe of activ iv (1 7-20 0) vas lound in thc chagasic and noii chagasic groups. Fhe enzvnie was (101 inh ihited bv 1:. ion u an of uhe groups. No sign iflcant differences were deteeted betveen the 1\Vo groups (clmtrasic and non chaasic) when the enzvrne vas tieatcd vith inhibitors such as [DTA and L-phenvia lan ¡ nc. 1 lowever, whcn the CN ionwas used, the enzynie of the normal pregnant vonien hllowed a Michaelian curve. whcreas ¡u Ihe chagasic group a sigmoideal piot vas observed. [hus. the Hill cocfhcmentwas 1.1 for the normal uroup and over 1 .5 lr (he chagasic.
Terapeútica con tuberculostáticos: cumplimiento en un hospital general
Authors: Polo Friz Hernán , Kremer Luis , Acosta Hernán , Abdala Omar , Cánova Sergio , Rojo Sandra , Roca Gabriela , Daín Alberto
Published: September 2024

lite purpose oíthis stud\ vas tu assess the complianccwitlt tuberculostatic drugs Ireatment ¡u a pimhlic hospital [rom Córdoba City aud tu estahi ish the causes of noncont p lance. AH the patients lo xvii ich lrcatmcnt vith tubercu lostatic cirugs \vas indicated roni .lanuarv 1 99 1 np lo December 1994 \vcre includecl. 45 palienls were imtclucled: 1 8 lmales (40%) and 29 males.Sixteen (35.69/o) did not complete the tinte ol treatment indicatecl. N inc (56.3%) abandoned the treatment 2 ntonthsatter havine initiated it. In de group that did not complete tIte trealnient there 'vas a It igher percentage of flntalc patieiltS (62.5%) than ¡u lite group that did complete it (27.6%). p 0.02. Ihere ''ere not statisticallv signi l'icant di lerences ¡u age. percentages ol pulntonar aud extiaptilmuonar tuberculosis ancl monlhs oftrcatment md icatecl beteen 1)1)111 gronps. lh rtv-six percent otthe pat ¡en t s w tu aba ndor cd thc Ireatmen t re te rred having interrupted it doe lo their O\Vli neglieencv. Lnovingthe risl ofsuch heltavior 36f suffered side ef'fects and did not come backtohospital:2 1 °-referred havinuconsulted another physician skho md icateci lo intcrrupt the treatnient svithaut perliirmn ¡ng othcr rests aud 7% mtiisunderstood de indications. It isconc luded that in a general hospital from Córdoba City. ihe percentage uI palients vho abancloned tubereu lostatic lreatment is It iglt In ntusl cases the cause vas relaleci tu Oiiitmres ni tite condnct ot patients. phvsicians or hoth.
Monodosis de FLEROXACINA para el tratamiento de la diarrea aguda estival en el adulto
Authors: Polo Friz Hernán , Kitsmann Patricia , Lalic Sylvia , Serra Joaquín , Rojo Sandra , Colazo Ana , Casero Rodolfo , Patrito Victorina , Pereyra de Santiago Oscar , Gandini Berbardo
Published: September 2024

Ihe purpose of this worL was lo evaluate Ihe ef113cacv and safi2tv ofa single dose of400 mgofllcroxacin foithe enlpiric antibiotic treat- inent oí' acote diarrhea in adu It patients. A prospective. double-blincl, placebo-control led, randomizcd trial vas designed. Al! the adult patients vho consu llecl iii our hospital br acute d iarrhea from December 1994 lo Apri 1 1995 were included. 72 patients were random- ized ni receive a single dose of 11eroxacin400 me and 73 were placebo. 1b rt -eight patients in each group were evaluable for efbcac) Bet\een both groups there were nol siatistical l sigtflcant dil'ferences in age, sex, number oí' ]ose stoo!s pci' clav at inclusion. davs since lile onset of svnlptoms op tu inclusion, other svnlpronis than ciiarrhea lit inclusion, percent- ages of bacterial pathogens and parasites sn- atecl aoci svniplonlatic treatnient indicatecl. At ihe thircl da) since inclusion. clinical cure oc- corred in 72.2% of lile patients receiving tieroxacin. comparecl Nviili 36.4% ofthose ie- ceivinc,p!aceho: p-0.002. Tilo niean±SD time tu cure was 2.2- 1 .2 davs iii the llel'oxacm gi'otip and13 .2—.() cla\s iii the placebo group: p=O.O 1 lwent\ -e¡(—,lit and 16.7% of patients reporteci aciverse et'6cts in lhc ileroxacin aoci placeboeroups respectiveiv: p=0.3. ¡lis concbuded that a singlecloscof lleroxacin 400 mg san effective and sale alternative for the entpiric antibiotic treatineni ob acote diarrhea o adults.
Estudio estructural comparativo de los blastomas gliales del Sistema Nervioso Central
Authors: Rodríguez Adelaida , Cejas Hugo
Published: September 2024

The objective ofour work is tu compare 2 diagnostics methods and denionstrate the similarities of the ditferent Central NervousSystem (ilial Tumor Classifications. 1 mm unomarki ng tec h niques for gliofibrilar acid protein (GFAP), and special silver impregnations to compare the results acco rdi ng tu the last h i stogen clic interpretations were Lised.
95 Glionias were studied with heniatoxiline-eosine and silver techniques, and in 58 randomized selected cases the techniquetor GFAP was also used Both iriethods showecl the sanie results in the diagnosis of Glial Tuniors whose cells possess gliotibn Is: Glioepitelioma (Ependynionia), (3 lioblastomu, Astroblastoma, and Astrocytoina.In the Oligodendrioglomas whose cells possess inicrotubules but not gliofibrils, 11-te silver tecliniques marked these cells and theirpi-olongitioiis while the technique for GFAP did not.Regardi ng (iliomas, there are similarities by coniparing dic Del Río Ortega- Polak classilication with those ofthe \VHO and other authors. There are differences only in ihe "mimes" of sorne tumors or ni their histogenetic interpretation, which are notsubstantial and are conhned to the "Polar Espongioblastorna'' and "Ghosarconia". Thercfore. ve think that the recongnitlon of the Del Río 1 Iortega-Poiak classification isjustilied.
Detección del virus Papiloma Humano en lesiones cancerosas orales en la ciudad de Córdoba
Authors: Bustos Dolores , Paván Jorge , Carricart Silvia , Talavera Ángel , Secchi Dante , Carrica Victoriano , Panico René , Gedelman Héctor
Published: September 2024

Oral cancer is a process thai involves diffurent etiological factors and meehanisms in the light of current view of viral cocarcinogenesis Evidenee from histology and DNA hybridization studies suggests that l-lPV is ingaged in oral carcinogenesis. The Pathology Laboratory of the Dentistry School, National University of Córdoba, admits approximately 20% of aH patients svith cancerous lesions in this city.In the January 1 992-December 1997 lapse, ve examined 1950 biopsies with oral lesions, 4.77% (93/1950 ) of which sere malignant neoplasnis. 79.571,1 /,, (74/93) were oral carcinomas. Thirty-three oral Carcinomas (44.6%; 33/74) were selcctcd at randoni andincluded in this study. 33 eells smears of normal oral mucosa of controls individuals were included. Thcy were analyzed by conventional [ight niicroSCOpy and an in situ hybridization technique for the detection o) HPV. Data were analyzed \vith chi square test. The prevalence of HPV among the 33 cancer samplcs studied vas 9/33 tested positive for l-IPV in low stringent conditions.Only one was positive in high stringent coiidi ion for 1-1 PV 16, a verrugous carcinoma. No HPV-DNA was detected in celis smcars ofcontrols. Aniong the I-IF'V positive, 3/9 (33 .33%)were squamous carcinomas and 5/9 (55.56%) were verrugous carcinomas. Onlyune vas a rrielanoma. Verrugous carcinoma vas the carcinoma most associated with the HPV inlection (x2 =20.5; 95% leve¡ ofconlidence). This would indicate a major role of FIPV in the pathogencsis of verrucous carcinomas. The viral prevalence found incancerous lesions reintbrces the concepi o)' 1ictcrogenic natures of oral cancer. HPV is a circumstancc tliat increase the probability of rnalignancy, and whcn reducing, diminish the frequency of cancer.
Aslamiento de vidrio cholerae no 01 de pacientes con gastroenteritis severa
Authors: Patrito E , Aliendro O , Lesa M
Published: September 2024

It was assay by biochemical and inmumological tests, strais of V. Cholerac non-O 1 non-O] 39 isolated froni two patients ofthe province of Córdoba, Argentina. They showed episodes of acote gastroenteritis. Strains non-O 1 non-O 139 werc isolatedfrom water samples ingested by palients. We conclude thai strains identified from patients would llave the source fromcontaminated enviromental water by V. Cholerae.
Comparación de abordajes antero lateral y p´osterior en artroplastia total primaria de cadera
Authors: Macedo Carlos , Galia Carlos , Rosito Ricardo , Valin Márcio , Kruel André , Müler Luis , Cejas Rodríguez Francisco
Published: September 2024

Comparison betv'een the antero-lateral and posterior approaches in pnimary total hip arthroplasty. In this retrospective study. 184 patients were enrolled, 95 submitted to the anterolateral (Watson .j ones) and 89 tu t he posterior approach (Moore) from June 1993 tu June 1997. The outcomes assessed were perioperative data (operative time, hospital stay, time from surgery unt il hospital discharge, surgical bleeding and the need for blood tmansfusion), as well as late complications (deep venous thronibosis DV P.pulnionary .emboltsm, periopheral nere injuiy, prothesis instability and others). Botlt groups did not diflr tu temis of preoperatieparanieters. Those subniitted to the posterior approach liad shorter operative times (p < 0,001), as well as redLtced bleeding (p 0,05)and need for blood transfusion (p < 0,001) durin surgery. The outcomes, such as late complications, liad simular reduced frequcncyin both groups. The posterior approach has been successfuly aplied in our service and proves to be an excellent alternative surgicalaccess to dic total hip artliroplastv.
Colectomía derecha ampliada. Lugar en el tratamiento del cáncer de colón izquierdo proximal obstructivo
Authors: Gramática (h) Luis , Lada Paul Eduardo , Mercado Luna Andrés , Badra Roberto , Bono Diego , Gramática Luis
Published: September 2024

The resu lts obtained about ni neteen (19) patients operated by left colon cancer with variable grade obstruction have buen analysed. Seventeen (17) patients operated doe tu obstructive leO colon cancer situated: Ove (5) ni distal transvcrse colon, other Ove (5) at splenic tiexure and seven (7) in proximal descending colon but threc of theni with right synchronic neoplasias. The reniaining two (2) that showed a cancer located at splenic [lexure and the other une m proximal descendi ig colon veie reuperated thrce weeks later than a ansverse colostomy liad been performecl owing lo an obstructive condition. (i)ne patienthad tu be reoperatcd because a generalised peritonitis fioni a tistula with partial disruption oil end tu end ¡leo-col ic anastomosisExteriorisation of both ends vas carried out with fiivourable evulution and subseclueni reanastomosis. An exteriorised patient bysplenic fiex ure cancer a Isu liad tu lic dra ned ten days later for a retroperitoneal ahsccss through a percutaneous puneture and a lesion grade 1 in lower pule of spleen vas resolved with electrofulguration. No patient has showed invalidating diarrhea and all themselves llave heen stabilised with two uy ifree stools daily about two rnonth afier surgery. Amplifying right colcctomy is a safe procedure with low surgical morbimortality and lake privileged place in the treatment of dic patients undergoing synchron ical neoplasias and/or carcinomas associatcd with polyps, specially in all those cases when a variable grade of obstruction have occurred.
Valor de la colangioresonancia magnético nuclear en el estudio del paciente ictérico
Authors: Gramática (H) Luis , Strunni Marcela , Carranza Diego , Varasay Guillermo , Taborda Bruno , Caballero Fabián , Gramática Luis
Published: September 2024

lhis report aiialyse ihe results ahoni foriy three (43) patienis. thirty six (3) otwhicli showed an extrahepatic obstructi ve biliarySyndroine Nvas mude evident by u It ras ono g ra ph y. fi ve (5) w it h a cholecistolithiasis and doubi ful ti istory of jaundice were evaluated to carry out a videosurgery procedure and two (2) pitieIits whoni hepatic-yeyunostomy had heen tiracticed, a control of anastomosis in postoperative period vas required. Nuclear Magnetic Resonance and Operative Cholangiography lindings were correlatcd and altcrward witli the anatoniopathological studies when thev arrived. In alt cases the Nuclear Magnctic Cholangio Resonance (NM('R) let os irovc the diagnosis of extrahepatie biliary ohstruction deterniining with precision furtherniorc the topographical site of the lesion. Respccting the aetiology of obstruction, NMCR was accuratein 34 out of 36 cases (94.4%). ln conclusion Cholangio-Resoniince is an excellent diagnostic rnethod to evaluate biliary ductilsystein including anatomic changes. 1 lowever, there are some limitat,ons vel in ordcr to determine the aetiology of' lesions about extrahepatic biliary vía extremes. Wc eniphasize its leatures sueh as non- invasive, little operati ng dependent. and \vi thoui morbimoru.il uy that become ii as a inethod of choice to study the biliary via l'rom a diagnostic viewpoint.
Proyecto de restructuración y reorganización en el área de la salud pública
Authors: Crossetto Mario , Caballero Gustavo
Published: September 2024

The ohjective of this projeci is to produce substantial change as regards the reorganization, reconsiruction and normal ization of the hospital data lo extra hospital data recording system froni the Ministry of l-lealth in the Province of Córdoba (Argentina). In order ti) incorporate socio-demogratic factors in fue various data thrms so asa ti) produce efticicncy opon the politic implemented. Ti) achicvc such mm, colwork on the diforent levels of execution, training the health team with respcct to fue identification of the population problems, and atternpiing to change of a demographic hasis the current sanitary policies nito polictes of populations.
TIMO ectópico cervical
Authors: Saracho Cornet Pedro León , Traversaro Mario , Courel José , Buteler Guillermo , Moreno Patricia , Ferreo Gabriel , Arias Marcelo
Published: September 2024

We present a case of eetopie ihynius iii tu eii..iht uiiontli Id mate hahs, svhii a rielit lateral luillor of the nec)'. I.eitupic llivinLis is apalhology raiel\ ohsers cd. lis eiiihrioetiesis coii!il e\philn lis Ceis leal ioci!iiatioii.
Aspectos básicos de la neuroendocrinoinmunología (NEI)
Authors: Correa Silvia , Rodríguez Galán María , Sotomayor Claudia
Published: September 2024

The purpose of this article is to discuss basic aspects of the interplay bciween the neuroendocrine and the irnrnune systems. Two pathways link the brain and the immune system: the autonomic nervous system and the neuroendocrine outflow via the pituitary. Most of the influence of the brain on inmune events is exerted through the hypothalamic-pituitaryadrenal (HPA) axis. Moreover, cei'tain neurotransmitters, neuropeptides, and neurohormones affect immune function both ¡o vivo and in vitro. Receptors for these molecules are present on immune cells. Thisceil-to-cell communication is bi-directional, since impulses from the immune system can affect many functions of the central nervous system. Cytokines released during the activation of the immune system, in turn, can alter the function of the IlPA axis. In this context, ve also describe our main findings working with a model of Candida albicans infection in rats exposed to chronic varied stress.
Tumores rabdomioblastos y neuroblastos
Authors: Cejas Hugo , Rodríguez Adelaida , Martinez Marcela
Published: September 2024

A metalic impregnation tecnique, Del Río Hortega's double impregnation, to evidence neuroblasts and rhabdomyoblasts, with recommendations as to the times of impregnation to obtains better results is eval uated.The images obtained are highly demostrative both of the embryo elements of the prinlitive mesenchyma from myoblast, myotube, a rhabdomyoblstic ribboned ccli wigh transverse streacks to the neoplasie elements of this lineage and to the neuroblasts with theirextensions. The stydy material includes a renal tumor of Wilms with rhabdomyoblasts and neuroblasts and a cerebellum neuroblastoma with a rhabdomyoblasic element. These injuries are considered dysembryoplasic.Wc also studied two botrioid embryo rhabdomyosarcomas, begin one or them unusually found in a menopausic woman, twoMüller mixed tumors of the uterus and Fallopian tubes, a rhabdomyoma in pharynx and three human embryos froni aborted material between 5 and 13 weeks oid. Wc emphasize the use of double impregnation to study rhabdomyobiasts and neuroblasts. In rhabdomyosarcom as, structures and elements similar to those of the embryo stageracketoid and ribboned ceils, myotubes andrhabdomyoblasts - can be observed. The tumor of Wilms is a dysembryoplasic tumor composed of renal blastem where we have found rhabdomyoblasts and neuroblasts. In the cerebe]lum neuroblastoma we observe rhabdomyoblasts with certain organicism(ectomesenchyma). Finalty, we describe a rather infrequent case of a cervix botrioid rhabdomyosarcoma of a menopausic woman.
La importancia de los auto- anticuerpos IGG específicos tipo II en la enfermedad de MENIERE y pérdida progresiva de la audición
Authors: Muino Juan , Carreras Roger , Ocampo Muriel , Ferrero Mercedes , Ferrero Piffiguer Marta , Landa Carlos , Beltramo Dante
Published: September 2024

The Meniere's Disease and Progressive Hearing Loss were considered idiopathic. Both entities were produced by endo lymphatic hydrops and disruption of the membrane which contain type II collagen. The inner ear presented widely expression of type II collagen. These pathologies were probably autoimmune diseases.The aim of this work was to study the relationship of specific IgO to type II collagen in Meniere's disease, Progressive hearing loss, and compared with Sudden hearing loss patients, vascular vertigo patients and normal controls. Patients were divided by clinical findings in: 1° Meniere's disease (n:27), 2° Progressive Hearing loss (n:20), 3° Sudden hearing loss (n: 15), 4° Vascular Vertigo (n:9) and compared with normal controls (n:30) aged and sex matched. Wc have measured specific IgG to type II collagen by ELISA test. We considered positive the OD two or more SD aboye the mean of normal controis. Results: 1° The Meniere's group presented IgG to type II collagen (+) in'.)'.) out of 27 patients, p<.025; 20 The Progressive Hearing loss presented 1gG to type II collagen in alt cases (n:20), p<.0005. The Sudden Hearing loss presented 1gG to type II collagen(-) in alt cases (n:15) p<.00001 and Vascular Vertigo (n:9) presented IgG to type II collagen (-) in 8 out of 9 cases, p<,0005. These results suggest strongly the notion that Meniere's diseases and Progressive hearing loss have specific IgG to type II collagen and these conditions were ascribed with in autoimmune process.
Divertículo de ZENKER: conducta terapéutica
Authors: Lada Paul , Florez Nicollini Francisco , Gramática (h) Luis , Finkelstein Javier , Struni Marcela , Mercado Luna Andrés , Gramática Luis
Published: September 2024

Background: Pharyngoesophageal or Zenker diverticula are a few frequent pathology that could represent between 1 and 3 % of the patients with dysfagia and their physiopatology even at present is scarcity clear.Objetive: Therapeutic procedures results about this patology were analyzed. Setting: Caraffa and Sucre Clinic.Design: Retrospective observational study.Method: It analyzed 13 patients operated by Zenker diverticula 9 of which were male and 4 were female sex with an averageage of 55,6 years. Dysfagia ocurred in 100 % of the cases. Besides clinical finding the diag- nosis was made evident by esophageal X-ray with contrast medium and endoscopy. Diverticulectomy by one stage through a left cervicotomy was the surgical procedure of choice.Results: There was no surgical mortality. Related with morbility 2 patients presented fistulas managed medically and inother 2 patients abscesses of surgical wound ocurred. The follow-up was carried on 6 months, 4 and 7 years respectively without relapses and with a good posterior evolution.Conclusions: Based on our short cxpericncc and the results attaincd we think the treatment of Zenker or pharyngoesophagealdiverticulum by diverticulectomy through a left cervicotomy is safe and effective procedure tocontrol this pathology.
Fibromatosis Mimicking clinically in vas! ve breast carcinoma
Authors: Piccinni Daniel
Published: September 2024

Our purpose is to report two cases of fibromatosis in two women of 34 and 48 years oid respectively that clinically appeared as ainvasive breast carcinoma, particular!y for the cutaneous retraction they showed. The histopathological diagnosis vas done basedon specimens studied with the common technique of paraffin embedding and Hematoxilin & Eosin staining. Both patients had firTn poorly demarcated nodules with the histopathological pattern of classic fibromatosis. Mammary fibromatosis is un infrequent relapsing entity, not suspected in differentiai ci inical diagnoses. The pathologist should bea it in niind , especially in frozen biopsiescialmente en las biopsias intraoperatorias.
Aspectos subcelulares de la inervación de las células intersticiales del ovario de embrión de pollo cultivado con LH O hCG
Authors: Ávila Rodolfo , Samar María , Ferraris Ricardo , Centurión Claudio
Published: September 2024

Severa¡ authors have shown the effect of LH or hCG gonadotrophins on steroid secrelion in the chick cmhryo ovary. However,the effects of luteinising horrnonc or human chorionic gonadotropin on chick emhryo ovary innervation have no[ heen studied. 1hc ptlrposc of the present work was to study the subcellular aspects of interstitial cells innervaliOn in chick enibryo ovaries cultured with LI-I or hCG Coobs White Rock female chick embryos at 7, 11 , 15 and 19 days of i ncubation (i n ovo) were employed. Explants of the left and right ovaries were cultured separately for 4 days in: 1- Basic medium (control): minimum essential medium(MEM-GIBCO) with 107 hovine fetal serum. 2- Basic medium with added LII or liCO (problems). The cultures were processed to bestudied ultrastructurally ('l'EM). Left and right ovary explants wore fixed two hours al room temperature in Karnovskys fixative. Thetissues were then post-fixed in osmiurn tetroxide i n 0. 1 NT cacodylate buffer for one hour and after a rinse in buffer were dehydrated in acetone; aftcrwards they were embedded in Araldite resin. Thick sections stained with 1 C/. Toluidine blue were examined and photographed using a Zeiss Photo II microscope. Thin sections were stained with uranyl acetate and lead citrate andexamined in a Siemens ElmisKop 101 electron microscope. Controls: In both ovaries the isolated interstitial cells and the appe:rance of nerve fibers and nerve endings were o!served in (he explants of 11 day cultured during four days and in a similar way at the age of 5 days of /o o vo clevelopmcnt. Problems : With\LH or hCG nerve fibers and nerve endings wer observed hoth in the right gonad and in the ¡nedulla of the left ovary in close cOntact with the steroid- producing interstitial ccl Is. Ultrastructurally, the interstitial cells are recognized by their typical oiganoids SER, Golgi apparatus. mitochondria with tubular crests and abundant lipidic droplets. The innervation of these cells were seen in ovaries at 7 days development, cultured during 4 days. The present state corresponds tothat of 11 days development in ovo. The nerve endings had mitochondria, microtubules and srnall and mediurn-sized vesicles, sorne with an electrodense content. These results jfl litro suggest that innervation of the ovaries is controlled by an indirect mechanism via the hypothalarnic-pituitary system and anoiher lo- cal with production neurotrophic factors modulated by LH.
Avalicao preliminar de un protocolo assistencial de artroplastia total de quadril
Authors: Galia Carlos Roberto
Published: September 2024

The hip arthrosis is a degenerativejoint disease occurring main]y in the elderly patients, a recently growing population. Rationalmeaswes are needed to better carry out the sur-¡cal procedurcsand lo reduce cost for the health system, since almost two thirds of the costs are due to the admission period. Therefore, a global, rnultidisciphinary assistance program for total hip arthroplasty (THAAP), including ambulatory appointments and programmed home care by a nursing team, was established to guide patients and theii' relatives for the procedure. This is a pilot study for a randomized prospective clinical trial to assess the feasibihity of the THAAP and to determine the protocol adherence by the medical and nurse team. Secondarily, it atternpts to determine the impact of the program on admission period, patient functional autonomy and postoperali ve events, as well as lo assess the lcasibiltty of theprogrammed nursing home-care. A total of 22 patients (8 males, 12 females) with mean (SD) age of 59.45 (16.87) ranging trom 21 to 86 years were includedin the study. They were divided into two groups according whether they were (group 1, n=10) or were not (group 2, n=10) included in the THAAP. The malo comorbidity for both groups were SAH (2 vs. 1). diabetes (1 vs. 0) and alcoho! consuniption (1 VS. 0), respectively. Mean (SD) postoperative (PO) period vas significantly reduced (p=0.0055) in group 1; 5.2 (0.4) as compared to group 2: 7.5 (2.3). Adherence to the THAAP was 9017ú and 10011, lordoctors and nurses, rcspectively. Seven outof nine patients in group 1 were bed-seated on the second POD, two were seated on the third POD and none were bed-ridden. Al¡of them were able to waik with crutches a day later. Al! patients in group 2 left bed on the fourth POD. In conclusion, the present protocol dernonstrated to he feasib!e, team adherence was adequate and resulted in a reduceci adrnission period. The progress of the program shall determine its cfficacy and the feasibility of programmed nursing home care.
Efecto de gangliósidos in vitro sobre linfocitos de pacientes chagásicos estimulados con motógenos o con antígenis de corazón o cerebro
Authors: Cabral Humberto R. A. , Novak Ivón T. C.
Published: September 2024

In human Chagas'dlsease previous work has shown the occurrence of a T-lymphocyte CD4-posltive population (a high producer of PAS-positive glycoprotelns) with evidence suggestlng a role In the formation of damages to the inyocardlum and neural structures in chagastc heart disease (ChHD) (5-7). Other workers have taken such facts Into consideration and have employed gangliosides (blological substances with neurotrophlc and !mmunomodulatory properties) in chagaslcs with chronic cardiomyopathy and disautonomic signs, obtainlng an improveinent in functional slgns and a decrease in the number of PAS+ lymphocytes (10). In the present work we have studied the effect of mixed gangliosides (Cronasslal') on cell cultures of total leukocytes, or on mononuclear cells preparecl through Flcoll-Hypaque. Bloocl vas obtalned from 14 patients with ChHD. Experlinents were undertaken to assess the effect of policlonal mltogens Phytohaernagglutinin (Phy) and Concanavalin A (Con A) on hlastic transformation, estimated by celi slze and cytologic study. In addition, the production of PAS+ substances by the lyniphocytes and blast were assessed. Gangliosides were added at final con centrations of 100 mg/ml or 200 ing/ ini. Ceil viability \vas assessed by means of the Trypan blue test. With respect to biastic transforination, results showecl a slgnlflcant ciecrease in the cultures that received gangliosides 24 hours before mit.ogen adnu nistration, as corupared with controis (1)<0.00 1) (both forPhyand Con A). Qn the other hand, the production of lyrnphocytic PAS+ substances decreaseci in the cultures of chagasics in which gangliosides were added. Sorne of these results confirmed previous findings on the matter (3). TI-te facts suggest that gangliosides can modulate sorne lyinphocytic activities In chagasics.
Índices de abundancia de larvas y pupas de Aedes Aegypti (diptera: Culicidae) en la ciudad de Córdoba
Authors: Almirón Walter , Asis Roberto
Published: September 2024

Background: In 1995, Aedes aegypti, vector of the Flavivirus Dengue and Yellow Fever, reached the province. Therefore, it is necessary to quantify the vector abundarice in order to determine the level of risk and to evaluate the prevention and control actlons implemented. Objectives: To determine the vector abundance breeding place preferences. Materials and Methods: Surveys of Ae. aegypti larva-pupa-infested containers were conducted in sta neighborhoods of Córdoba city in order to determine the House, Container, and Breteau Indices. Results: Larvae and pupae of Ae. a.egypti we re fou nd in a great variety of containers, most of which had been discarded. The House Index obtained was 47 %, whlle the percentage of water-holding containers examined that had larva or pupa was 24 %. The Breteau Index was estimated at 106 % Conclusions: According to the indices estimated, Córdoba city is In a risk situation if any infected person vith any dengue virus enters our city. Therefore, it Is necessary to lntensify the measures, mainly the sanitary education, vector surveillance and control, in order to prevent any form of dengue in the reglon
Extendidos delgados en la punsión aspiración con aguja fina de tiroides: un estudio de 200 casos
Authors: Irizar María , Spitale Luis , Piccini Daniel , Godoy Graciela
Published: September 2024

Introduction:Trying to increase the specificity and demostrated sensibility oh thyroid fine needle aspiration (TFNA) in the diagnosis of the thyroid nodule, and to improvide the citomorphologic diagnosis, we used the approach of realization of thin prep (TP), adapting the technique to the methods withing our possibilities. Materials and methods: The sample corresponded to a prospective study of 2020 cases of material of thyroid nodules, obtained by means of ultrasonography guide fine needle aspiration, over a 30 month period. The study was carried out by means of conventional smear (CS) and TP, cytologic preparations were stained with hematoxilin - ecosine (H-E), Papaconicolaou (PAP) and Ting 15. The analysis of these same samples was carried out according to sex, age, characteristics of the nodules and cytomorphologic features. Results: The samples were satisfactory in 184 cases (92%)and unsatisfactory in 16 cases (8%). The prevalence in samples corresponded to the female sex (88.5%). The presemptive diagnoses corresponded to: Multinodular Goiter: 41 (22.29%) - Hashimotos lesions I: 86 (46.74%), II: 34 (18.47%), III: 6 (3.26%) - Hurthle cell neoplasm: 4 (2.17%) - Papillary carcinoma: 9 (4.90%). The patient study was carried out according to the modified algorithm proposed by Gharib in 1997 and the Department of Citology of the Karolinska Hospital of Stockolm (Sweden. The cytological diagnosis was compared to the final histological resultds.
Conclusions: The present work has demonstrated that even with the available methods, we have been able to carry out TP that were acceptable for its evaluation and with the same limitations of those obtained by CS, with respect to preparations dried in direct air and in the cases of non- conclusive diagnoses. We obtained a sensibility of 94.44% and a specificity of 98.79%.
Costo directo demestral por artritis reumatoidea en pacientes que concurren a un hospital universitario
Authors: Audisio Marcelo , Strusberg Ingrid , Orellana Barbera Sergio , Drenkard Cristina , Barberis Gloria , Gamrón Susana , Onetti Carlos
Published: September 2024

Introduction: There are no medical puhlical.ions with economic analysis of rheumatoid arthritis patients (RA) from Argentina are lackirig. The objective of the present study is to determine the direct cost and its breakdown in patients with RA. Material and Methods: Fifty.- two patients who met the American College of Rheumatology RA entena were included. Direct cost was calculated over a follow-up period of 6 months during year 2001. Variables were analyzed with Student's T test, Mann-Whitney U Test, cor ANOVA as corresponded. P values <0.05 were considered significant. Results: The mean monthly home income was $426.6 SD 272. The mean half-yearly direct costs was $677,5 SD 376.2. The components of the direct cost were identified and the mean for medication cost vas $606.7 (89%), for lab tests was $45,5 (7%), for medical attention $12,5 (2%) and other costs$2.4. No differences in total cost or in medication cost were found when compared considering age, evolution time of RA or HAQ scores. Conclusion: Haif- yearly direct cost in RA is excessively high considering the monthly mean income of the patients being analyzed. The cost of medication was the principal component of the direct cost.
Trombosis aguda carotídea en el traumatismo penetrante: ¿ Es necesaria la revascularización en el paciente sin déficit neurológico central?
Authors: Fuentes Javier , Montenegro Rolando , Casaretto Eduardo , Quelas Jorge , Procikieviez Oscar , Canga Carlos , Florez Nicolini Francisco
Published: September 2024

Introduction: Carotid lesions requirepriority in both evaluation and treatmentdue (o their high morbidity and mortality.Controversy about, therapeutic behavior in these patients with or without central neurological deficit is still under in discussión. Objectives: To prescnt a patient with acute carotid trombosis due to a shotgun wound and discuss its therapeutic behavior. Setting: Hospital de Urgencias in Córdoba city. Material and methods: A 15year-old male patient is presenteci with a "point-blank" shoigun wound in the soí't parts of theleft cervical region, and a Ieft carotid trombosis with no central neurological déficit, Results: Wound toilette and carotid revascularization by means of resection and venous by-pass with extcrnal carotid ligature was performed. The procedure was finished by delaging for plastic reconstruction of the cervical injury. Carotid postoperative angiographic control showed good permeability with no carotid flow alteration. Conclusion: Penetrating carotid injuries should be resolved, if technically possible, with revascularizalion oí' [he carotid sector.This procedure has to be aborted if the palienl is in coma or ihe lesion is difficult to repair, in such a case ligature shouldbe carried out.
Brote de infección por Enterococcus Faecium resistentes a glicopéptidos en un hospital de Rosario, Argentina
Authors: All Laura , Vera Blanch Marcela , Mocarbel Nicolás , Limansky Alejandro , Viale Alejandro , Notario Rodolfo
Published: September 2024

Eriterococci causes serious ihlness in immunocompromised patients and in severely ill. hospi talized patienis. Thcy are comrnonly isolated from the human gastrointestinal tract, and rcsistance to vancomycin has increased in frequency during the past fewyears. We report three cases of nosocomial vancomycin resistant Enterococcus faecium (VRE) infections from September to Decemberof 2000. A 54-year-old man presented post surgical wound infection due lo VRE after 2 months of hospitaliza tion. The seconcl is a 65-year-old neutropenic patient with a medical history of acute mieloici leukemia and esophageal carcinoma. In this case, central venous catheter was colonized with EVR. The third, a 65-year-old wornan who received therapy with ceftriaxone, ciprofloxacin and clindamicin had a urinary tract infection due to EVR. The three isolates were resistant to vancornycin (MIC value > 256 pg/ml). The DNA amplification pattern obtained by OD-PCR were similar in the three cases
Sildenafil citrate for the treatment of patients with cardiovascular diseases with exclusion of coronary artery disease and hypertrophic subaortic stenosis
Authors: Iosa Daniel
Published: September 2024

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Rotura bilateral de tendón cuadricipital
Authors: Modrego Francisco , Molina Juan
Published: September 2024

Si mu! t a neo us bilateral, a u ci spontaneous rupture of thc quadriceps tcnclon isavery rare injurv. Individuals with this injury are usuallv prcdisposecl by chronic renal diseasc with secondary hyperparathyroidism, gout, diabetes, ancl lupus erythematosus. Often, primary diagnostie confusion can lead lo a clelay in trcatment. Two cases ofa bilateral lesion of the divadlriceps tenclon, lhat were treatecl surgicallv using the techniciue of Scuderi, followecl by art in tense rehabilitation programine , are i resenteci . Surgical treatnient yields salisfactory results.
Histiocitosis de células de Langerghans de la vulva (reporte de un caso)
Authors: Cremonezzi David , Bruno Mónica
Published: September 2024

Langerhans' cdl histiocytosis (LCH) is a proliferative clisease that rnost oflen affects chi.lclren. Prescutation ofvulvar lesion alone in adults is rare. Wc report a case of a 69-year-o1d woman with a vulvar lesion of 6 years of evolution. IlE stain and ininiunohistochemical study using CTK, ACL, 11M13 45, VIM. S 100. LN 5 y CD la were performed. CLH, although unusual presentation. it is must keep ni nund when appear vulvar lesions in older woman simulating infection or proliferative ncoplastic lcsions of skin since is necessary rule out sysleniic engagement and perioclical control of patient
Endometriosis de pared abdominal: presentación de un caso
Authors: Vélez Sebastián , Piccini Daniel José , Caminos Susana , Spitale Luis Santos , Ferrari Juan Carlos
Published: September 2024

Endometriosis is defined as the prcsence o encloinetrial glancis and stroma outside uterus. Tliis ectopie finding occur in the abdominal wall among 0,03% to 1% of women with prior gynecologic surgery, particularly after cesarcan section. Most frequently, endonietriosis is present as a palpable mass, painfuil cluring menstrual period, near surgical scar. It could minuc other pathologies such as hematomas, granuloinas. inicisional hernias, abscesses and tumors. Wc report the case of a 35 years old woman with a painful mass during nienstruation nearly cesarean scar. The tumor was completely removed and a polipropylen niesh vas placed to repair the abdominal wail defect. It vas identifieci as endometriosis in the anatorno-patologic examination.
Efecto renoprotector de altas dosis periprocedimiento de n-acetilcisteína oral en pacientes programados para someterse a una angiografía el mismo día
Authors: Baderramo Domingo , Badra Verdu Mariano , Ramacciotti Constanza , Cremona Luis , Lemos Pablo , Orías Marcelo , Moreyra Jr Eduardo
Published: September 2024

BACKGROUND: Few studies that have assessed the effect of abbrcviated oral Nacctylcysteine (NAC) rcgimens in radiocontrast-induced nephropat hy (RCIN)yield mixed results. OBJECTJVE: To evaluate the rcnoprotective effect of high periprocedural oral doses (HPOD) of NAC in patients with chronic renal impairmcnt undergoing a same-day angiography. METHODS: Sixty one paticnts vi1Ii renal impaired function scheduled to undcrgo a same-day angiography were randomly assigned to NAC 1200 ing orally 3 hours before and 3 after the procedure, or a placebo. Al! patients received 0.9% salme intravenous. RCIN was defined as an increase in SCC > 0.5 mg/dl 48 hours after the procedure. RESULTS: The mean baseline SCC for all patients was 1.44 ± 0.42 mg/dl. A slgnificant difference in SCC change at 48 hours after the angiography was found (-0.07 mg/dl NAC, 0.09 mg/dl placebo, P=0.04). RCIN occurred in 1 (3%)patient of NAC group and in 2 (7.1%) patients of placebo group (P=0.59). Adverse effects were similar in both groups. CONCLUSIONS: In patients withmild renal impairment patients undergoing angiographic procedures. HPOD of NAC were more effective than placebo in preventing SCC change 48 hours. A non slgnlficant benefit in RCIN incidence vas found.
Proliferación y apoptosis en epitelio lingual de ratones con tumores salivales inducidos por Dimetilbenzantraceno (DMBA) y modulados por lípidos dietarios
Authors: Actis Adriana , Valentich Mirta , Cremonezzi David , Cockes Silvia
Published: September 2024

Introductiomi: Aecorcling to the concept of fielcl defeets during the careinogenesis process, cxcessive cpithelial proliferation/ apoptosis may exist iii arcas near tunlors. Proliferation or apoptosis cou Id be mnodified by dietary lipids. Purpose: The present stucly vas designed ro analyze proltferation and apoptosis in tongue epitheliurn of inice Ucd cliets bascd nn different lipicls followed Uy induction of salivary tumors with DMBA. Mateninls and Methods: Forty-five clays after weaning, ten BALB/c mice were assigned to two chets: coro oil (CO) and fish oil (eod liver, FO). 'i\vo weeks later. DMBA vas injccteclin the submandibular area. Animals were sacrificed at the 13th post-in(ection weck. Sarnplcs of tongue were fixecl in formnalinethanol and irnmunohistocheinically stained for proliferation (Ki-67) and apoptosis (Bax). By light inicroseopv, the number of nuclei positive for theseniarkers were countcd out of three-hundred total interphase celis both in dorsal and in ventral tongue surfaces. Results were analyzed through Analysis ofVariance and t Test. Resu]ts: Cell proliferation vas greater in dorsal than in ventral tongue surfaces (p<0.0001) with no diet difference. Apoptosis wassignificantly greater in mice fed FO than CO, particularly in tongue dorsal epithelia (p<O.Ol 8). Conclusions: This study shows that FO diet induces higher leveis of apoptosis in tongue epithelia suggesting a tissue defensive mechanism when exposed to a carcinogenic-tumoral agent
Permanencia de la cultura Piamontesa en las prácticas alimentarias de descendientes de tercera generación de la localidad del Piamonte (Proviencia de SAnta fé, Argentina)
Authors: Andreatta María , Muñoz Sonia , Navarro Alicia
Published: September 2024

This paper describes ¿he inJluencc' of lle piernonLese culture ort food pro dices o[studenls living in Piamonte, Santa Fe, Argentina. Food practices of 96 studertls with Piamontese anceslry (PA) (n=57) and wittioul Piarnoritese anceSlr/J (No-PA)(n=39) werestudied alorig 2002 usirtg a self-adm inislered cjues 1 lonnare. Dala were analysed by Chi scjuare test, Fisher's exaci test, ni ultipie correspondance analtjsis and logis(ic regression. Consumplion of hagna cal-ida (p< 0.05 ) aoci polenta (p< 0.1) were /iigher arnong PA. D(Jjerences on Ihe elahoralion of polenta cind pasta werefounc1: PA acici litera cheese (p< 0.05) and crearn (p< 0.05) whereas no-PA ma/ce use of meal (p< 0.05) and lorna(o sauce (p<O.OS), respectively. Tite frequency of consurnption of tradilional Piarnontese rneals anc! ¿he role of tite moiher in tite purchase, the elaboral ion arid the serving of lhefood were similar on boih groups. In conclusion, food practices of Pianiontese's descendariis recaí! Ihe food culture of ¿heir ancestry wilh sorne reasonahie adaptations to the local context.
Blanco terapeutico en artritis reumatoidea
Authors: Casado Gustavo , Alba Paula
Published: September 2024

The principle of "Protein targeting" includes an indispensable approach in the prevention of complications of some of the most prevalent diseases such as diabetes, hypertension and coronary artery disease. These diseases lead to high mortality and their preventive treatment should be a public health priority.
La Investigación en Atención Primaria de la Salud
Authors: Cuestas Eduardo
Published: September 2024

Hablar de investigación en atención primaria parece algo quimérico, al no disponer ésta de la alta tecnología presumida siempre imprescindible para una investigación médica de calidad, o no atender casos de patología grave en la que se invierten cuantiosos recursos económicos, o también por no concentrar una casuística amplia de enfermedades poco frecuentes. Además por la dispersión típica de la atención primaria, los pediatras se sienten, frecuentemente aislados, faltándoles el estímulo del grupo de pediatras o de residentes y alumnos. Todo esto sin mencionar la gran presión asistencial y la ausencia de profesores universitarios con tiempo y formación para dedicarse a dirigir académicamente las investigaciones garantizando su necesidad, factibilidad, utilidad y calidad.
Food preferences and their “decision contexts” as predictors of dietary pattern
Authors: Andreatta María Marta , Del Campo María Lis , Carbonetti Adrián , Navarro Alicia
Published: September 2024

The Food Frequency Questionnaire (FFQ) is the usual method for estimating dietary intake in epidemiological studies. However, investigations focused only on nutrient and food intake does not show the reason why, where or how people choose certain foods and reject others. Food preference and its choosing decision helps to explain more accurately why people eat certain foods and how this freedom of choice is implemented. Thus, we decided to design and validate a Food Preference Questionnaire (FPQ) to be applied in adults under nutritional epidemiological studies. This FPQ was applied to 60 adults of both sexes, who lived in Córdoba, Argentina, and in the nearby cities of the Greater Córdoba region. The validity of the FPQ was estimated through the Spearman correlation coefficient and calculated by using SPSS 17.0, and the determination coefficient was also estimated. The correlation between the number of subjects who indicated a preference for a particular food or meal, and its frequency of consumption gave a result of rs=0.5 (p <0.1), whereas the determination coefficient had a value of r2= 0.25. Thus, the dietary patterns of adult population from Córdoba were estimated by assessing food preferences. The biological, psychological and socio-cultural aspects of the food decision context, in addition to their complex relations, may contribute to understand better the choice of food intake hence precluding the role of dietary practices in health and disease.
Xantomatosis plana difusa asociada a tumor hematológico y neoplasia sólida. Hallazgos de una autopsia
Authors: Bürgesser María Virginia , Calafat Patricia , Diller Ana
Published: September 2024

Diffuse plane xanthomatosis is an uncommon subtype of non-Langerhans histiocytosis. We report a case of a 78 year-old woman with a history of monoclonal gammopathy of undetermined significance and diffuse plane xanthomatosis since 1995. She consulted for malaise and died four days after admission. Autopsy was requested. Findings were diffuse plane xanthomatosis with extensive involvement of internal organs, lymphoplasmacytic lymphoma and cecal adenocarcinoma. Final event was acute bronchopneumonia. This entity is a subtype of histiocytosis. It affects skin and involves mucous membranes in 40% of the cases. Extracutaneous extension has been reported. It is usually associated with haematologic disorders. In this case, the patient had a lymphoplasmacytic lymphoma and colonic adenocarcinoma. We highlight the importance of recognition its association with monoclonal gammopathies and solid tumors in order to make a proper follow up of patients.
Riesco de hemorragia en pacientes mayores de 85 años anticoagulados por fibrilación auricular
Authors: Revigliono José I. , Amuchastegui Tomás , Contreras Alejandro E. , Amuchastegui Marcos
Published: September 2024

Background: Atrial fibrillation is the most common cardiac tachyarrythmia and is an important independent risk factor for ischemic stroke. Its prevalence begins to increase in both sexes after 40 years of age as well as the risk of hemorrhage. The aim of this study was to compare the annual rate of hemorrhagic events between patients older and younger than 85 years, with diagnosis of nonvalvular atrial fibrillation and anticoagulated with warfarin. Material and methods: A retrospective study was performed. We included 118 patients with diagnosis of nonvalvular atrial fibrillation monitorized by an informatized follow up system. Results: The study follow-up was 28,2 ±17,5 months and 24 patients (20,3%) were older than 85 years of age. The rate of major bleedings was 4,62%/year (older than 85 years) vs 0,95%/year (younger than 85 years) , p= 0,05, OR 6,57 (IC 95% 1,04-41,8) and minor bleeding was 4,62%/year (older than 85 years) vs 5,2%/year (younger than 85 years), p=0,99, OR 1,08 (IC 95% 0,28-4,21). There was no difference in the Time in Therapeutic Range between both groups (56.4 ± 16.3 % vs 60.5 ± 17.7 %, p 0,30). Conclusion: The age should not be considered a contraindication to anticoagulant therapy, however, special care and careful monitoring of patients older than 85 years should be considered due to they had high risk of bleeding.