bluuebunny/crossref_metadata_2025 huggingface dataset:
Radiolabeling strategies and pharmacokinetic studies for metal based nanotheranostics
Authors: Ranjbar Bahadori Shahab , Mulgaonkar Aditi , Hart Ryan , Wu Cheng‐Yang , Zhang Dianbo , Pillai Anil , Hao Yaowu , Sun Xiankai
Published: October 2020

Radiolabeled metal‐based nanoparticles (MNPs) have drawn considerable attention in the fields of nuclear medicine and molecular imaging, drug delivery, and radiation therapy, given the fact that they can be potentially used as diagnostic imaging and/or therapeutic agents, or even as theranostic combinations. Here, we present a systematic review on recent advances in the design and synthesis of MNPs with major focuses on their radiolabeling strategies and the determinants of their in vivo pharmacokinetics, and together how their intended applications would be impacted. For clarification, we categorize all reported radiolabeling strategies for MNPs into indirect and direct approaches. While indirect labeling simply refers to the use of bifunctional chelators or prosthetic groups conjugated to MNPs for post‐synthesis labeling with radionuclides, we found that many practical direct labeling methodologies have been developed to incorporate radionuclides into the MNP core without using extra reagents, including chemisorption, radiochemical doping, hadronic bombardment, encapsulation, and isotope or cation exchange. From the perspective of practical use, a few relevant examples are presented and discussed in terms of their pros and cons. We further reviewed the determinants of in vivo pharmacokinetic parameters of MNPs, including factors influencing their in vivo absorption, distribution, metabolism, and elimination, and discussed the challenges and opportunities in the development of radiolabeled MNPs for in vivo biomedical applications. Taken together, we believe the cumulative advancement summarized in this review would provide a general guidance in the field for design and synthesis of radiolabeled MNPs towards practical realization of their much desired theranostic capabilities.

This article is categorized under:

Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

Diagnostic Tools > Diagnostic Nanodevices

Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
On three-point functions in ABJM and the latitude Wilson loop
Authors: Bianchi Marco S.
Published: October 2020

Abstract

I consider three-point functions of twist-one operators in ABJM at weak coupling. I compute the structure constant of correlators involving one twist-one un-protected operator and two protected ones for a few finite values of the spin, up to two-loop order. As an application I enforce a limit on the gauge group ranks, in which I relate the structure constant for three chiral primary operators to the expectation value of a supersymmetric Wilson loop. Such a relation is then used to perform a successful five-loop test on the matrix model conjectured to describe the supersymmetric Wilson loop.
Microscopic Derivation of the Fröhlich Hamiltonian for the Bose Polaron in the Mean-Field Limit
Authors: Myśliwy Krzysztof , Seiringer Robert
Published: October 2020

We consider the quantum mechanical many-body problem of a single impurity particle immersed in a weakly interacting Bose gas. The impurity interacts with the bosons via a two-body potential. We study the Hamiltonian of this system in the mean-field limit and rigorously show that, at low energies, the problem is well described by the Fröhlich polaron model.
Differential regulation of osteopontin and CD44 correlates with infertility status in PCOS patients
Authors: Paravati R. , De Mello N. , Onyido E. K. , Francis L. W. , Brüsehafer K. , Younas K. , Spencer-Harty S. , Conlan R. S. , Gonzalez D. , Margarit Lavinia
Published: October 2020

Endometrial receptivity is mediated by adhesion molecules at the endometrium-trophoblast interface where osteopontin (OPN) and CD44 form a protein complex that plays an important role in embryo recognition. Here, we undertook a prospective study investigating the expression and regulation of OPN and CD44 in 50 fertile and 31 infertile ovulatory polycystic ovarian syndrome (PCOS) patients in the proliferative and secretory phases of the natural menstrual cycle and in 12 infertile anovulatory PCOS patients. Endometrial biopsies and blood samples were evaluated for expression of OPN and CD44 using RT-PCR, immunohistochemistry and ELISA analysis to determine circulating levels of OPN, CD44, TNF-α, IFN-γ and OPN and CD44 levels in biopsy media. Our findings highlighted an increased level of circulating OPN and CD44 in serum from infertile patients that inversely correlated with expression levels in endometrial tissue and positively correlated with levels secreted into biopsy media. OPN and CD44 levels positively correlated to each other in serum and media from fertile and PCOS patients, as well as to circulating TNF-α and IFN-γ. In vitro analysis revealed that hormone treatment induced recruitment of ERα to the OPN and CD44 promoters with a concomitant increase in the expression of these genes. In infertile patients, inflammatory cytokines led to recruitment of NF-κB and STAT1 proteins to the OPN and CD44 promoters, resulting in their overexpression. These observations suggest that the endometrial epithelial OPN-CD44 adhesion complex is deficient in ovulatory PCOS patients and displays an altered stoichiometry in anovulatory patients, which in both cases may perturb apposition. This, together with elevated circulating and local secreted levels of these proteins, may hinder endometrium-trophoblast interactions by saturating OPN and CD44 receptors on the surface of the blastocyst, thereby contributing to the infertility associated with ovulating PCOS patients.

Key messages

• Endometrial epithelial OPN-CD44 adhesion complex levels are deficient in ovulatory PCOS patients contributing to the endometrial infertility associated with ovulating PCOS patients.

• Circulating levels of OPN, CD44 and inflammatory cytokines TNF-α and IFN-γ are altered in infertile PCOS patients.

• Increased levels of both OPN and CD44 in biopsy media and serum inversely correlate with endometrial expression of these markers in endometrial tissue.

• In infertile PCOS patients, high levels of oestrogens and inflammatory cytokines stimulate the recruitment of transcription factors to the OPN and CD44 promoters to enhance gene transcription.

• Our study identifies a novel crosstalk between the CD44-OPN adhesion complex, ERα, STAT1 and NF-κB pathways modulating endometrial receptivity.
No detrimental effect of a positive family history on postoperative upgrading and upstaging in men with low risk and favourable intermediate-risk prostate cancer: implications for active surveillance
Authors: Herkommer Kathleen , Maier Nikola , Ankerst Donna P. , Schiele Stefan , Gschwend Jürgen E. , Meissner Valentin H.
Published: October 2020

Purpose

To assess whether a first-degree family history or a fatal family history of prostate cancer (PCa) are associated with postoperative upgrading and upstaging among men with low risk and favourable intermediate-risk (FIR) PCa and to provide guidance on clinical decision making for active surveillance (AS) in this patient population.

Methods

Participants in the German Familial Prostate Cancer database diagnosed from 1994 to 2019 with (1) low risk (clinical T1c–T2a, biopsy Gleason Grade Group (GGG) 1, PSA < 10 ng/ml), (2) Gleason 6 FIR (clinical T1c–T2a, GGG 1, PSA 10–20 ng/ml), and (3) Gleason 3 + 4 FIR (clinical T1c–T2a, GGG 2, PSA < 10 ng/ml) PCa who were subsequently treated with radical prostatectomy (RP) were analysed for upgrading, defined as postoperative GGG 3 tumour or upstaging, defined as pT3–pT4 or pN1 disease at RP. Logistic regression analysis was used to assess whether PCa family history was associated with postoperative upgrading or upstaging.

Results

Among 4091 men who underwent RP, mean age at surgery was 64.4 (SD 6.7) years, 24.7% reported a family history, and 3.4% a fatal family history. Neither family history nor fatal family history were associated with upgrading or upstaging at low risk, Gleason 6 FIR, and Gleason 3 + 4 FIR PCa patients.

Conclusion

Results from the current study indicated no detrimental effect of family history on postoperative upgrading or upstaging. Therefore, a positive family history or fatal family history of PCa in FIR PCa patients should not be a reason to refrain from AS in men otherwise suitable.
Darcy, Forchheimer, Brinkman and Richards: classical hydromechanical equations and their significance in the light of the TPM
Authors: Ehlers Wolfgang
Published: October 2020

In hydromechanical applications, Darcy, Brinkman, Forchheimer and Richards equations play a central role when porous media flow under saturated and unsaturated conditions has to be investigated. While Darcy, Brinkman, Forchheimer and Richards found their equations mainly on the basis of flow observations in field and laboratory experiments, the modern Theory of Porous Media allows for a scientific view at these equations on the basis of precise continuum mechanical and thermodynamical investigations. The present article aims at commenting the classical equations and at deriving their counterparts by the use of the thermodynamical consistent Theory of Porous Media. This procedure will prove that the classical equations are valid under certain restrictions and that extended equations exist valid for arbitrary cases in their field.
How I do it: minimally invasive resection of a sub-ependymoma of the fourth ventricle
Authors: Corniola Marco V. , Meling Torstein R.
Published: October 2020

Background

A 54-year-old female was referred to our clinic with a lesion of the lower fourth ventricle extending to the median aperture. Here, we report the use a minimally invasive sub-occipital approach (MISA) as a safe and effective surgical management.

Method

We performed a MISA using a short midline incision and a 1-cm sub-occipital craniectomy. Dissection of the lesion was performed, and “en bloc” resection could be achieved. The lesion was confirmed to be a grade I sub-ependymoma.

Conclusion

MISA can be safely used when confronted to a lesion of the lower fourth ventricle.
Identification of possible dynamical drivers for long-term changes in temperature and rainfall patterns over Europe
Authors: Hoffmann Peter , Spekat Arne
Published: October 2020

This study looks into the question to what extent long-term change patterns of observed temperature and rainfall over Europe can be attributed to dynamical causes, in other words: Are the observed changes due to a change in frequency of the patterns or have the patterns’ dynamical properties changed? By using a combination of daily meteorological data and a European weather-type classification, the long-term monthly mean temperature and precipitation were calculated for each weather-type. Subsequently, the observed weather-type sequences were used to construct analogue time series for temperature and precipitation which only include the dynamical component of the long-term variability since 1961. The results show that only a fraction of about 20% of the past temperature rise since 1990, which for example amounted to 1 °C at the Potsdam Climate Station can be explained by dynamical changes, i.e. most of the weather-types have become warmer. Concerning long-term changes of seasonal rainfall patterns, a fraction of more than 60% is considerably higher. Moreover, the results indicate that for rainfall compared with temperature, the decadal variability and trends of the dynamical component follow the observed ones much stronger. Consequently, most of the explained seasonal rainfall variances can be linked to changes in weather-type sequences in Potsdam and over Europe. The dynamical contribution to long-term changes in annual and seasonal rainfall patterns dominates due to the fact that the alternation of wet and dry weather-types (e.g. the types Trough or High pressure over Central Europe), their frequencies and duration has significantly changed in the last decades.
Association of lipid profiles with severity and outcome of acute ischemic stroke in patients with and without chronic kidney disease
Authors: Zhang Ailing , Deng Wenjing , Zhang Bin , Ren Mengyang , Tian Long , Ge Jihui , Bai Jinjuan , Hu Hao , Cui Ling
Published: October 2020

Background

Contribution of lipid profiles to stroke severity and outcome was inconclusive, whether chronic kidney disease (CKD) (estimated glomerular filtration rate < 60 mL/min/1.73 m2) affects the association has not been investigated. We aim to evaluate this relationship.

Methods

A retrospective study of consecutive acute ischemic stroke patients was performed. We assessed the risk of severe stroke with the National Institutes of Health Stroke Scale (NIHSS) ≥ 5 at admission and poor outcome with the modified Rankin Scale (mRS) ≥ 3 at discharge. Multivariate stepwise logistic regression models were adopted to study interaction and independent association of lipid components with stroke severity and outcome according to lipid level quartiles by CKD stratification.

Results

Among the 875 included patients (mean age 64.9 years, 67.8% males), 213 (24.3%) presented with CKD. Elevated low-density lipoprotein cholesterol (LDL-C) was independently associated with severe stroke in patients with CKD (P for trend = 0.033) than in those without CKD (P for trend = 0.121). The association between the level of LDL-C and stroke severity was appreciably modified by CKD (Pinteraction = 0.013). Compared with without CKD patients in the lowest LDL-C quartile, the multivariable-adjusted risk of severe stroke increased significantly by 2.9-fold (95% CI 1.48–5.74) in patients with CKD in the highest LDL-C quartile. No significant association was observed between lipid components and early outcome in patients with and without CKD.

Conclusion

LDL-C levels are positively associated with stroke severity in only patients with CKD, with an interactive impact of LDL-C and CKD on ischemic stroke in the acute phase.
Physical and chemical characteristics of slag produced during Pb refining and the environmental risk associated with the storage of slag
Authors: Kicińska Alicja
Published: October 2020

Metallurgical waste originating from the Zn and Pb refining process presents varying chemical composition and physical properties and contains varying quantities of pollutants. In the study, both fresh and weathered samples of production slag from the final Pb refining process were used to determine its physical parameters and chemical composition as well as to perform an environmental risk assessment (RAC, mRAC) related to its storage. This paper focuses on determining parameters such as natural humidity (1.8%) and bulk density (1267 kg/m3) of the slag. Also, its toxicity was analysed using bio-tests, its pH was measured (11.92) and the content of sulphates (3.5 wt%), chlorides (0.3 wt%) and selected heavy metals (Cd, Cu, Fe, Mn, Zn, Pb) was determined. The Individual Contamination Factor was determined, yielding the following order of the hazard level: Pb > Cu > Zn > Cd > Fe > Mn. Based on the mobility of metals determined using the Mobility Factor, it was concluded that the hazard level followed the sequence Cd > Pb > Zn > Mn > Fe > Cu. The obtained water leaching results were compared to the values found in the legal regulations in force. Based on this comparison, it was established that the slag studied constitutes toxic waste containing considerable quantities of sulphides and chlorides. The material is also a considerable source of readily leaching elements (Cd, Zn and Pb), and thus any product created using the slag may become hazardous to the environment. Also, the waste studied must not be used in the form in which it is currently stored due to the leaching of particularly toxic elements (Cd and Pb) in water solutions with increasing acidity.
Hybrid evolutionary oligopolies and the dynamics of corporate social responsibility
Authors: Tichý Tomáš , Radi Davide , Lamantia Fabio
Published: October 2020

The diffusion ofcorporate social responsibilityis investigated by employing a hybrid evolutionary game where a firm chooses between being either socially responsible, which implies devoting a fraction of its profit to social projects, or non-socially responsible. Consumers prize socially responsible companies by paying a higher reservation price for their products. The hybrid evolutionary framework is characterized by a quantity dynamics that describes the oligopolistic competition given firms’ belief about the composition of the industry. At regular intervals of time, this belief is endogenously updated by a retrospective comparison on the profits obtained and on the basis of an evolutionary mechanism. Assuming that firms are Nash players, that is at each instant of time they produce the Nash equilibrium-in-belief quantity, the investigation of the model reveals that an industry homogeneously populated by socially responsible firms is a stable equilibrium when the fraction of profits earmarked for socially responsible activities is sufficiently limited. However, the extra marginal profits of a socially responsible firm are reduced when the number of competitors increases, impeding the diffusion of socially responsible companies. In particular, the trade-off between a higher net margin on sales obtained by socially responsible firms and a lower level of production that reduces the profit gap between a socially responsible firm and the rest of the market shows that an increased size of the industry favors mixed oligopolies. Moreover, imposing the hypothesis of neutrality of CSR activities, the model reveals that being socially responsible is an evolutionarily stable strategy for firms and is convenient for customers. Relaxing the hypothesis of Nash players by introducing boundedly rational firms that decide their level of production according to a partial adjustment toward the best reply, the robustness of these results is confirmed.
Gibbs States, Algebraic Dynamics and Generalized Riesz Systems
Authors: Bagarello F. , Inoue H. , Trapani C.
Published: October 2020

In PT-quantum mechanics the generator of the dynamics of a physical system is not necessarily a self-adjoint Hamiltonian. It is now clear that this choice does not prevent to get a unitary time evolution and a real spectrum of the Hamiltonian, even if, most of the times, one is forced to deal with biorthogonal sets rather than with on orthonormal basis of eigenvectors. In this paper we consider some extended versions of the Heisenberg algebraic dynamics and we relate this analysis to some generalized version of Gibbs states and to their related KMS-like conditions. We also discuss some preliminary aspects of the Tomita–Takesaki theory in our context.
Landfall After the Perfect Storm: Cohort Differences in the Relationship Between Debt and Risk of Heart Attack
Authors: O’Rand Angela M. , Hamil-Luker Jenifer
Published: October 2020

Analyses of the Health and Retirement Study (HRS) between 1992 and 2014 compare the relationship between different levels and forms of debt and heart attack risk trajectories across four cohorts. Although all cohorts experienced growing household debt, including the increase of both secured and unsecured debt, they nevertheless encountered different economic opportunity structures and crises at sensitive times in their life courses, with implications for heart attack risk trajectories. Results from frailty hazards models reveal that unsecured debt is associated with increased risk of heart attack across all cohorts. Higher levels of housing debt, however, predict higher rates of heart attack among only the earlier cohorts. Heart attack risk trajectories for Baby Boomers with high levels of housing debt are lower than those of same-aged peers with no housing debt. Thus, the relationship between debt and heart attack varies by level and form of debt across cohorts but distinguishes Baby Boomer cohorts based on their diverse exposures to volatile housing market conditions over the sensitive household formation period of the life course.
Absorption Pigment Cores for Pearlescent Pigments
Authors: Matejdes Marián , Hausner Josef , Grüner Michael , Kaupp Günter , Breu Josef
Published: October 2020

A lustrous appearance and interference-based colors make pearlescent pigments attractive for use in applications such as automotive paints, plastics, consumer electronics, and cosmetics. A combination of interference and absorption in the visible light spectrum improves significantly the hiding power as well as the color strength of pearlescent pigments while potentially extending their color range. The aim of the present study was to introduce synthetic fluorohectorites, having an appreciable diameter (~20 μm) and aspect ratio (~1000), as promising colored cores for pearlescent pigments. Fluorohectorites can adopt a variety of colors by ion-exchange reaction with cationic organic dyes of high absorption coefficient. Unlike related dye-exchanged natural montmorillonite clays, which undergo acid activation accompanied by release of dye at low pH, as is required for subsequent coating with TiO2 in an environment with low pH and elevated temperature, no leaching was observed with dye-exchanged synthetic fluorohectorites ([Na0.5]int.[Mg2.5Li0.5]oct.[Si4]tet.O10F2). Due to its significantly greater layer charge, more organic dye molecules were adsorbed per volume of the fluorohectorite than for montmorillonite. Consequently, the free volume available in the interlayer space for H3O+ diffusion was less for synthetic fluorohectorite than for montmorillonite. Acid attack via interlayer space was, therefore, retarded significantly for fluorohectorite. Acid attack from the external edges of synthetic fluorohectorites was in the range of conventionally applied mica pigment core (fluorophlogopite, ([K]int.[Mg3]oct.[AlSi3]tet.O10(F,OH)2) because of the comparable large diameter of the platelets. Montmorillonite, however, occurs with particle diameters typically <200 nm and the much increased relative contribution of edges to the total surface area also makes them more prone to acid attack and concomitant leaching. Aside from leaching stability, the confinement of organic dyes in the interlayer space restricts rotational and vibrational motions, which in turn stabilizes the dyes typically by ~100°C against thermal decomposition as compared to chloride salts of the dyes.
The in vitro toxicity evaluation of halloysite nanotubes (HNTs) in human lung cells
Authors: Sawicka Dorota , Zapor Lidia , Chojnacka-Puchta Luiza , Miranowicz-Dzierzawska Katarzyna
Published: October 2020

Halloysite nanotubes (HNTs) have been increasingly used in many industrial and biomedical fields. Therefore, the assessment of risk and consequences of exposure to HNTs is very important to better protect human safety. This study aims to investigate the short- (24 or 72 h) and long-term (7 days) cytotoxic effects of HNTs at doses 10–200 µg/mL on human alveolar carcinoma epithelial cells (A549) and human bronchial epithelial cells (BEAS-2B). The effect of HNTs on cell viability, apoptosis, cell proliferation, oxidative/antioxidative status and cell morphology was evaluated. Our results showed that cytotoxicity of HNTs is dependent on dose, cell model and time of exposure. During the time of exposition toxic effects were intensified. To the best of our knowledge, this is the first study to use holo-tomographic microscopy (HTM) to visualise changes in cell morphology due to exposure from HNTs. We observed cells contraction, changes in the size and shape, cell surface folding and cytoplasmic vacuolization, peripheral arrangement of cell nuclei and even increase number of nucleus, which undoubtedly confirmed cytotoxic effect of HNTs at low doses (5 µg/mL and 25 µg/mL). Our results demonstrated that HTM technique provides a new insight into the assessment of HNTs toxicity. Further studies with different cell models are recommended to assess the toxic effect of HNTs on whole human body.
Gender in Childhood
Authors: Brown Christia Spears , Biefeld Sharla D. , Tam Michelle J.
Published: October 2020

Gender is a highly salient and important social group that shapes how children interact with others and how they are treated by others. In this Element, we offer an overview and review of the research on gender development in childhood from a developmental science perspective. We first define gender and the related concepts of sex and gender identity. Second, we discuss how variations in cultural context shape gender development around the world and how variations within gender groups add to the complexity of gender identity development. Third, we discuss major theoretical perspectives in developmental science for studying child gender. Fourth, we examine differences and similarities between girls and boys using the latest meta-analytic evidence. Fifth, we discuss the development of gender, gender identity, and gender socialization throughout infancy, early childhood, and middle childhood. We conclude with a discussion of future directions for the study of gender development in childhood.
The perspective of children of hoarding parents (COHP)
Authors: Garrett Cecilia A.
Published: October 2020

The perspective herein is based upon the lived experience of adult
Children of Hoarding Parents (COHP). The weight of parental hoarding on COHP
is not derived solely from the physical adversity of living within a hoarded
home but also comes with the social and psychological challenges they carry
into adulthood. The view of hoarding as a family disorder with lasting
impact evokes research questions including the exploration of the
relationship between childhood adversity and parental hoarding, and the
application of attachment theory to hoarding behaviours and family
relationships. These types of research studies may lead to policy adoption
and programme development for early identification of and intervention
within families where parental hoarding represents a threat to child
welfare.
Grammar modulates discourse expectations: evidence from causal relations in English and Korean
Authors: YI EUNKYUNG , KOENIG JEAN-PIERRE
Published: October 2020

abstract

This paper investigates whether differences in grammar affect the production of discourse relations. We report the results of two story continuation experiments on speakers of two typologically unrelated languages, English and Korean, and in two different discourse genres, monologues (Experiment 1) and conversations (Experiment 2), focusing on the contrast between the explanation discourse relation and the result discourse relation. Since the grammar of clause linkage in Korean, but not English, disfavors a backward causal order (explanation relation), we predicted that Korean speakers are less likely to produceEXPLANATIONcontinuations inMONOLOGUESthan English speakers. We also predicted that this difference disappears in conversation, as questions that can be uttered in conversations are not subject to the same constraints on clause linkage in Korean. The results confirmed our predictions. The effect of language on the production of discourse relations in monologue suggests thatLINGUISTIC STRUCTUREScan affect speakers’ discourse expectation and production, while the absence of language effect in conversation suggests that this language effect is not due to differences in the way speakers causally relate events or to conceptual or cultural differences in preferences for iconic discourse between English and Korean speakers.
In Search of the Lands of Rus’: The Idea of Ukraine in the Imagination of the Little Russian Movement (1917–1919)
Authors: Korolov Gennadii
Published: October 2020

The article explores the idea of Ukraine in the imagination of the Little Russian politicians during the revolutionary period of 1917–1919. It chiefly focuses on figures of the Little Russian movement, such as Vasiliy Shulgin (1878–1976), Anatoliy Savenko (1874–1922), Andrey Storozhenko (1857–1926), Aleksandr Bilimovich (1876–1963), and others. This article explores the ideas of the Little Russians regarding the termUkraineand their views concerning the Ukrainian people and its ethnographic and historical boundaries. It argues that Ukraine and Ukrainians were perceived as a Little Russia, Southern Russia, Southern Rus’, and Little Russians accordingly. By their assessment, Ukraine had not included the Taurida (the New Russia region) and the Crimea, but had included Eastern Galicia and Volhynia.
All Sizes Fit the Red Queen
Authors: Žliobaitė Indrė , Fortelius Mikael
Published: October 2020

The Red Queen's hypothesis portrays evolution as a never-ending competition for expansive energy, where one species’ gain is another species’ loss. The Red Queen is neutral with respect to body size, implying that neither small nor large species have a universal competitive advantage. Here we ask whether, and if so how, the Red Queen's hypothesis really can accommodate differences in body size. The maximum population growth in ecology clearly depends on body size—the smaller the species, the shorter the generation length, and the faster it can expand given sufficient opportunity. On the other hand, large species are more efficient in energy use due to metabolic scaling and can maintain more biomass with the same energy. The advantage of shorter generation makes a wide range of body sizes competitive, yet large species do not take over. We analytically show that individuals consume energy and reproduce in physiological time, but need to compete for energy in real time. The Red Queen, through adaptive evolution of populations, balances the pressures of real and physiological time. Modeling competition for energy as a proportional prize contest from economics, we further show that Red Queen's zero-sum game can generate unimodal hat-like patterns of species rise and decline that can be neutral in relation to body size.
ON SOLVABILITY OF CERTAIN EQUATIONS OF ARBITRARY LENGTH OVER TORSION-FREE GROUPS
Authors: ANWAR MUHAMMAD FAZEEL , BIBI MAIRAJ , AKRAM MUHAMMAD SAEED
Published: October 2020

Let G be a nontrivial torsion-free group and $s\left( t \right) = {g_1}{t^{{\varepsilon _1}}}{g_2}{t^{{\varepsilon _2}}} \ldots {g_n}{t^{{\varepsilon _n}}} = 1\left( {{g_i} \in G,{\varepsilon_i} = \pm 1} \right)$ be an equation over G containing no blocks of the form ${t^{- 1}}{g_i}{t^{ - 1}},{g_i} \in G$. In this paper, we show that $s\left( t \right) = 1$ has a solution over G provided a single relation on coefficients of s(t) holds. We also generalize our results to equations containing higher powers of t. The later equations are also related to Kaplansky zero-divisor conjecture.
Viability and development of Ascaridia galli eggs recovered in artificial media followed by storage under different conditions
Authors: Feyera T. , Ruhnke I. , Sharpe B. , Elliott T. , Campbell D.L.M. , Walkden-Brown S.W.
Published: October 2020

Eggs oviposited by Ascaridia galli females in artificial media are commonly used as a source of infective material. We investigated the rate of egg production by cultured mature females (n = 223), and changes in egg viability under different storage and incubation conditions. Eggs recovered after 1, 2 or 3 days of culture were subjected to either (1) storage in water at 4°C (1, 4 or 8 weeks) followed by incubation in 0.1 N H2SO4 at 26°C (2, 4 or 6 weeks); or (2) prolonged storage at 4°C (up to 14 weeks). Egg development and viability was assessed by morphology coupled with a viability dye exclusion test of hatched larvae. Of the 6,044 eggs recovered per mature female 49.2, 38.5 and 12.3% were recovered on days 1, 2 and 3 of worm incubation respectively with similar initial viability (≥99%) between days. Eggs recovered on different days had only minor differences in viability after storage. The prolonged storage period at 4°C significantly affected both viability and embryonation ability resulting in decline in viability of 5.7–6.2% per week. A smaller but significant decline in egg (2.0%) and hatched larval (1.4%) viability per week of incubation at 26°C was also observed. We conclude that storage and incubation conditions, not the day of egg recovery, are the main factors affecting A. galli egg viability. Our findings indicate that under aerobic conditions storage at 26°C may be preferable to 4°C whereas other studies indicate that under anaerobic conditions storage at 4°C is preferable.
Risk factors for severe disease in patients admitted with COVID-19 to a hospital in London, England: a retrospective cohort study
Authors: Goodall J. W. , Reed T. A. N. , Ardissino M. , Bassett P. , Whittington A. M. , Cohen D. L. , Vaid N.
Published: October 2020

COVID-19 has caused a major global pandemic and necessitated unprecedented public health restrictions in almost every country. Understanding risk factors for severe disease in hospitalised patients is critical as the pandemic progresses. This observational cohort study aimed to characterise the independent associations between the clinical outcomes of hospitalised patients and their demographics, comorbidities, blood tests and bedside observations. All patients admitted to Northwick Park Hospital, London, UK between 12 March and 15 April 2020 with COVID-19 were retrospectively identified. The primary outcome was death. Associations were explored using Cox proportional hazards modelling. The study included 981 patients. The mortality rate was 36.0%. Age (adjusted hazard ratio (aHR) 1.53), respiratory disease (aHR 1.37), immunosuppression (aHR 2.23), respiratory rate (aHR 1.28), hypoxia (aHR 1.36), Glasgow Coma Scale <15 (aHR 1.92), urea (aHR 2.67), alkaline phosphatase (aHR 2.53), C-reactive protein (aHR 1.15), lactate (aHR 2.67), platelet count (aHR 0.77) and infiltrates on chest radiograph (aHR 1.89) were all associated with mortality. These important data will aid clinical risk stratification and provide direction for further research.
Covering and tiling hypergraphs with tight cycles
Authors: Han Jie , Lo Allan , Sanhueza-Matamala Nicolás
Published: October 2020

A k-uniform tight cycle $C_s^k$ is a hypergraph on s > k vertices with a cyclic ordering such that every k consecutive vertices under this ordering form an edge. The pair (k, s) is admissible if gcd (k, s) = 1 or k / gcd (k,s) is even. We prove that if $s \ge 2{k^2}$ and H is a k-uniform hypergraph with minimum codegree at least (1/2 + o(1))|V(H)|, then every vertex is covered by a copy of $C_s^k$. The bound is asymptotically sharp if (k, s) is admissible. Our main tool allows us to arbitrarily rearrange the order in which a tight path wraps around a complete k-partite k-uniform hypergraph, which may be of independent interest.

For hypergraphs F and H, a perfect F-tiling in H is a spanning collection of vertex-disjoint copies of F. For $k \ge 3$, there are currently only a handful of known F-tiling results when F is k-uniform but not k-partite. If s ≢ 0 mod k, then $C_s^k$ is not k-partite. Here we prove an F-tiling result for a family of non-k-partite k-uniform hypergraphs F. Namely, for $s \ge 5{k^2}$, every k-uniform hypergraph H with minimum codegree at least (1/2 + 1/(2s) + o(1))|V(H)| has a perfect $C_s^k$-tiling. Moreover, the bound is asymptotically sharp if k is even and (k, s) is admissible.
CFAP43-mediated intra-manchette transport is required for sperm head shaping and flagella formation
Authors: Yu Yi , Wang Jiaxiong , Zhou Liming , Li Haibo , Zheng Bo , Yang Shenmin
Published: October 2020

Mutation inCFAP43leads to severe asthenozoospermia and multiple morphological abnormalities of the sperm flagellum (MMAF) in both human and mouse. Previous studies have shown that disruption of intra-manchette transport (IMT) caused failure of flagellum assembly and sperm head shaping. In a previous study, therefore, we postulated that disruption of IMT may contribute to the failure of sperm flagellum formation and result in MMAF, however the mechanisms underlying these defects are still poorly understood.Cfap43-deficient mice were studied here to reveal the cellular mechanisms of abnormal sperm head morphology and MMAF. Depletion ofCfap43led to abnormal spermiogenesis and caused MMAF, sperm head abnormality and oligozoospermia. Furthermore, both abnormal manchette and disorganized ectoplasmic specialization (ES) could be observed at the elongated spermatids inCfap43-deficient mice. Therefore, our findings demonstrated that, in mice, CFAP43-mediated IMT is essential for sperm head shaping and sperm flagellum formation.
Midterm outcomes of pulmonary artery sling repair with and without tracheoplasty
Authors: Binsalamah Ziyad M. , Thomason Alyssa , Ibarra Christopher , Spigel Zachary , Adachi Iki , Barton Katherine E. , Edmunds Evan , Caldarone Christopher A. , Imamura Michiaki , Heinle Jeffrey S.
Published: October 2020

Objective:

Review a single-centre experience with pulmonary artery sling repair and evaluate risk factors for re-intervention.

Methods:

Patients with surgically repaired pulmonary artery sling at a single institution between 1996 and 2018 were retrospectively reviewed. A univariate Cox regression analysis was used to evaluate variables for association with freedom from re-intervention.

Results:

Eighteen patients had pulmonary artery sling repair. At operation, median age and weight were 6.9 months (interquartile range 4.1–18.1) and 9.5 kg (interquartile range 6.5–14.5), respectively. A median hospital length of stay was 12 days (interquartile range 5.8–55.3). Twelve patients (67%) had complete tracheal rings, of whom six (50%) underwent tracheoplasty (five concurrently with pulmonary artery sling repair). Airway re-intervention was required in five (83%) of the six patients who underwent tracheoplasty. One patient had intraoperative diagnosis and repair of pulmonary artery sling during unrelated lesion repair and required tracheoplasty 24 days post-operatively. One patient died 55 days after pulmonary artery sling repair and tracheoplasty following multiple arrests and re-interventions. Median post-operative follow-up for surviving patients was 6.3 years (interquartile range 11 months–13 years), at which time freedom from re-intervention was 61%. When controlling for patient and tracheal size, initial tracheoplasty was associated with decreased freedom from re-intervention (hazard ratio 21.9, 95% confidence interval 1.7–284.3, p = 0.018).

Conclusions:

In patients with pulmonary artery sling, tracheoplasty is associated with decreased freedom from re-intervention. In select patients with pulmonary artery sling and complete tracheal rings, conservative management without tracheoplasty is feasible. Further study is necessary to delineate objective indications for tracheoplasty.
Propranolol syrup to tablets change triggers electrical storm in Jervell-Lange-Nielsen syndrome
Authors: Ramos-Jiménez Javier , Sánchez-Perez Inmaculada , Moreno-Mata Nicolás , Moreno-Planas Javier
Published: October 2020

A 10-year-old girl with genetically confirmed Jervell-Lange-Nielsen syndrome treated with beta-blocker and developed electrical storm after changing propranolol syrup to tablets. Jervell-Lange-Nielsen is characterised by long QT and congenital sensorineural deafness, with high risk of malignant arrhythmias at early ages. Gastric involvement and achlorhydria may be present, with subsequent alteration of medication bioavailability which can trigger severe arrhythmic complications.
The Covert and Overt Reassurance Seeking Inventory (CORSI): Development, validation and psychometric analyses
Authors: Radomsky Adam S. , Neal Rachael L. , Parrish Chris L. , Lavoie Stefanie L. , Schell Sarah E.
Published: October 2020

Background:

Reassurance seeking (RS) is motivated by perceived general and social/relational threats across disorders, yet is often under-recognized because it occurs in covert (i.e. subtle) and overt forms. Covert safety-seeking behaviour may maintain disorders by preventing corrective learning and is therefore important to identify effectively.

Aims:

This study presents the validation and psychometric analyses of a novel measure of covert and overt, general and social/relational threat-related interpersonal RS.

Method:

An initial 30-item measure was administered to an undergraduate sample (N = 1626), as well as to samples of individuals diagnosed with obsessive compulsive disorder (OCD; n = 50), anxiety disorders (n = 60) and depression (n = 30). The data were subjected to exploratory and confirmatory factor analyses, and validation analyses.

Results:

An exploratory factor analysis using principal axis factoring with oblique rotation yielded five interpretable factors, after removing four complex items. The resulting 26-item measure, the Covert and Overt Reassurance Seeking Inventory (CORSI), evidenced good convergent and divergent validity and accounted for 54.99% of the total variance after extraction. Factor correlations ranged from r = .268 to .736, suggesting that they may be tapping into unique facets of RS behaviour. In comparison with undergraduate participants, all clinical groups had significantly higher total scores [t (51.80–840) = 3.92–5.84, p < .001]. The CFA confirmed the five-factor model with good fit following the addition of four covariance terms (goodness of fit index = .897, comparative fit index = .918, Tucker–Lewis index = .907, root mean square error approximation = .061).

Conclusion:

The CORSI is a brief, yet comprehensive and psychometrically strong measure of problematic RS. With further validation, the CORSI has potential for use within clinical and research contexts.
SHOULD THE PRIVATE SECTOR PROVIDE PUBLIC CAPITAL?
Authors: CHATTERJEE SANTANU
Published: October 2020

The choice between private and government provision of a productive public good like infrastructure (public capital) is examined in the context of an endogenously growing open economy. The accumulation of public capital need not require government provision, in contrast to the standard assumption in the literature. Even with an efficient government, the relative costs and benefits of government and private provision depend crucially on the economy's underlying structural conditions and borrowing constraints in international capital markets. Countries with limited substitution possibilities and large production externalities may benefit from governments encouraging private provision of public capital through targeted investment subsidies. By contrast, countries with flexible substitution possibilities and relatively smaller externalities may benefit either from governments directly providing public capital or from regulation of private providers. The transitional dynamics also are shown to depend on the underlying elasticity of substitution and the size of the production externality.
Arguments used by trade associations during the early development of a new front-of-pack nutrition labelling system in Brazil
Authors: Mialon Melissa , Khandpur Neha , Amaral Mais Laís , Bortoletto Martins Ana Paula
Published: October 2020

Objective:

To analyse the arguments used by the food industry during the early development of the new nutrition front-of-pack labelling (FOPL) in Brazil.

Design:

A thematic qualitative analysis was performed using an inductive approach. All data were collected and analysed between December 2018 and April 2019. Data included documents published by the Brazilian government, including industry’s contributions to a technical public consultation, as well as industry material and newspaper articles.

Setting:

Brazil.

Participants:

Seven trade associations and one industry group.

Results:

During the early stages of the FOPL policy development, food industry actors presented themselves as legitimate actors, by highlighting their economic contribution to the country, their role in safeguarding consumers’ right to choose and their range of solutions in addressing the non-communicable disease epidemic. They also questioned the policy process by criticising the role of the Brazilian Health Regulatory Agency and the science that informed the policy. Finally, food industry actors highlighted the supposedly lack of coherence between national, regional and international policies, as well as other socio-economic risks. A small set of evidence published in non-academic, non-peer-reviewed reports was used by industry actors to support these arguments.

Conclusions:

Collectively, these arguments reinforced the position of the food industry as a necessary part of the discussion on FOPL and shifted the blame away from unhealthy products to individual behaviours. It is crucial that public health initiatives, such as the introduction of a new FOPL, are no co-opted and negatively influenced by economic actors who may try to delay the policy process.
Empire, sociality, and political economy in colonial Bengal
Authors: Sartori Andrew
Published: October 2020

How to conceptualize the broad dissemination of economic concepts in colonial South Asia? This article uses an essay by a mid-nineteenth-century Bengali, Peary Chand Mittra, as a point of departure to approach this problem in South Asian historiography. In the first part, the essay locates the conditions of possibility for Mittra's political-economic analysis of Bengal's agrarian social order within an imperial and commercial space of extended interdependencies. The aim is not to explain the specificity of Mittra's politics so much as to highlight his recourse to political-economic concepts to ground his analysis. In the second part, the essay suggests that the grounding of political economy's colonial histories within histories of imperial space needs to be supplemented by closer attention to new normative impulses and aspirations emerging directly from agrarian society in the region. This second emphasis provides better grounds for grasping the depth and durability of political economy's reach into political and ethical claims across social space in the Subcontinent in the twentieth century. It thus broaches the necessity of subaltern histories of political economy.
The Self in Fragments: On Rowan Williams’s Tragicomic Augustinianism
Authors: Delport Khegan M.
Published: October 2020

This paper aims to expound Rowan Williams’s reading of Augustine and Hegel on the question of selfhood. Through an adoption of the tropes of ‘tragedy’ and ‘comedy’, the argument will be made that Williams’s interpretation of Augustine’s portrayal of the soul as wandering and homeless does not imply an unremitting vision of loss and fragmentation. For him, the distentio animi is always placed within a more expansive arc of desire in which the self is continually rediscovered in what is ‘other’. This means that my self is most primarily found in the unhanding of restrictive identities that hinder our spiritual growth towards union with God, and also in the discovery of my goods as being bound up with the goods of others. This reading is further expanded by relating Williams’s ‘Augustine’ to Gillian Rose’s ‘Hegel’, thereby showing the way that his reception of this has assisted him in explicating a greater ‘comic’ undercurrent in his retrieval of selfhood.
Terrestrial Radio Signals May Suppress High-Energy Electrons
Authors: Rehnberg Morgan
Published: October 2020

Naval radio signals may cause the formation of a barrier observed during geomagnetic storms that is seemingly impenetrable by relativistic electrons.