bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGGUNAAN MEDIA PEMBELAJARAN AUDIO VISUAL UNTUK MENINGKATKAN MOTIVASI BELAJAR IPS
Authors: Farhah Faridah Nur
Published: March 2024

The monotonous lecture method makes students' attention to learning less so that an interesting learning tool is needed and can foster student learning motivation. One of the media that can be used is video because there are two elements, namely audio and visual. In its use, videos are favored by students because they make it easier to understand learning material so that students are motivated to learn. This research method uses a qualitative type of research with a case study approach. Data collection is obtained through three ways, namely interviews, observation, and documentation. Data analysis is carried out in four stages, namely data collection, data presentation, verification/conclusions, and data reduction. Test the validity of the data using source triangulation and triangulation techniques. The results showed: The use of audio- visual learning media in social studies subjects went well, student learning motivation was good because students felt happy and interested and actively involved in learning, the advantages of audio-visual media during learning made it easier for teachers to present material and made it easier for students to understand the material. The obstacle faced lies in technical obstacles, namely electricity that goes out during learning.

ABSTRAK

Metode ceramah yang monoton membuat perhatian siswa akan pembelajaran berkurang sehingga diperlukan sebuah perangkat pembelajaran yang menarik serta dapat menumbuhkan motivasi belajar siswa. Salah satu media yang dapat digunakan adalah video karena terdapat dua unsur yakni audio dan visual. Pada penggunaannya, video digemari siswa karena memudahkan dalam memahami materi pembelajaran sehingga siswa termotivasi untuk belajar. Metode penelitian ini menggunakan jenis penelitian kualitatif dengan pendekatan studi kasus. Pengumpulan data diperoleh melalui tiga cara yaitu wawancara, observasi, dan dokumentasi. Analisis data dilakukan dengan empat tahapan yaitu pengumpulan data, penyajian data, verifikasi/penarikan kesimpulan, dan reduksi data. Uji keabsahan data menggunakan triangulasi sumber dan triangulasi teknik. Hasil penelitian menunjukkan: Penggunaan media pembelajaran audio visual pada mata pelajaran IPS berlangsung dengan baik, motivasi belajar siswa baik karena siswa merasa senang dan tertarik serta terlibat aktif dalam pembelajaran, kelebihan media audio visual pada saat pembelajaran memudahkan guru dalam menyajikan materi dan memudahkan siswa dalam memahami materi. Kendala yang dihadapi terletak pada kendala teknis, yakni listrik yang padam saat pembelajaran berlangsung.
Translation, Cultural Adaption, and Linguistic Validation of the Norwegian Wound-QoL Questionnaire
Authors: Schwartz Monica Maria , Pukstad Brita Solveig , Utvær Britt Karin , Haugan Gørill , Ljosaa Tone Marte
Published: March 2024

Background and Purpose:A sound translation is complex but necessary to provide a valid patient-reported questionnaire. The aim of this study was therefore to translate, culturally adapt, and linguistically validate the 17-item Wound-Quality of Life (Wound-QoL) questionnaire from English to Norwegian.Methods:For translation and cultural adaption of the Wound-QoL, we followed the methods described by the ISPOR—The Professional Society for Health Economics and Outcomes Research (formerly, the International Society for Pharmacoeconomics and Outcome Research), Messaging Application Programming Interface Research Institute, and recommendations from literature reviews.Results:Differences in the language semantics and syntax caused challenges in the translation. The cognitive debriefing interviews revealed some irrelevant items related to personal preferences.Conclusions:This study provides a questionnaire that can improve the quality of clinical care and promote research and valuable knowledge to other researchers translating the Wound-QoL and similar questionnaires.
Evaluation of Immunobiological Cold Chain Costs
Authors: Andrade Heuler Souza , Cazarim Maurílio de Souza , de Oliveira Valéria Conceição , Baldoni André Oliveira , Guimarães Eliete Albano de Azevedo
Published: March 2024

Background and Purpose:Studies assessing the costs of the immunobiological cold chain (CC) are scarce. Therefore, the factors that influence the allocation of resources in this process are not known. The objective of this study is to determine the cost of the immunobiological CC.Methods:The Health Economic Assessment study was carried out in Minas Gerais, Brazil, between 2021 and 2022. The unit of analysis was the municipal level of the CC. The perspective of the Public Health System (Sistema Único de Saúde) was considered as a funder, the year 2021 was considered as the time frame, and the period of 1 year was considered as the time horizon of the analysis. Direct medical, nonmedical, and indirect costs were included. A mixed technique was used involving micro- and macrocosting and sensitivity analysis to identify the influence of the main categories on the final cost.Results:The total cost was U.S. dollars 20,014,545, with nonmedical direct costs being the most representative (61.24%). Human resources were the most influential items, representing 76.43% of the total cost.Conclusions:The most influential items should be those of greatest concern and planned by managers to make the CC more efficient.
Development and Psychometric Assessment of “Self-Efficacy Scale” for Patients With Beta Thalassemia Major: A Mixed-Methods Study
Authors: Hasani Narenjbaghi Soghra , Valizadeh Leila , Zamanzadeh Vahid , Ghahramanian Akram , Asghari-jafarabadi Mohammad
Published: March 2024

Background and Purpose:Since self-efficacy is a significant factor influencing the self-management of chronic diseases, including thalassemia major, it is considered a key concept in chronic diseases. This study aimed to develop and psychometrically evaluate the self-efficacy scale for patients with thalassemia major.Methods:This was a mixed-methods study conducted in two phases. In phase 1, a qualitative study with a conventional content analysis design was conducted. In phase 2, which was a quantitative one, the psychometric analysis of the instrument’s phrases was done.Results:The instrument has 35 items and 3 factors. The Cronbach’s alpha coefficient and the intraclass correlation coefficient were .93 and .94, respectively.Conclusions:This study confirms the validity and reliability of the Beta Thalassemia Major Self-Efficacy Scale. With this tool, nurses can evaluate the self-efficacy of patients with thalassemia major.
Our Needs Have Been Ignored for a Long Time: Factors Affecting the Willingness of Black and Hispanic/Latinx Sexual and Gender Minority Communities to Donate Biospecimens
Authors: Ceja Alexis , Bruno Victoria , Panyanouvong Nicholas L. , Aguilar Jose , Raygani Sawye , Lubensky Micah E. , Dastur Zubin , Lunn Mitchell R. , Obedin-Maliver Juno , Flentje Annesa
Published: March 2024

The study aimed to document factors affecting the willingness to engage in biospecimen donation for substance use research among Black and Hispanic/Latinx sexual and gender minority (SGM) people. From May to July 2022, we interviewed 22 Black and Hispanic/Latinx SGM people from The Population Research in Identity and Disparities for Equality Study, a cohort of SGM people in the United States and its territories, using Zoom videoconferencing software. Fourteen participants were cisgender sexual minority people, and eight participants were gender minority people who were also sexual minority. We took an inductive, collaborative qualitative analytic approach to identify themes. Themes included the following: (1) community benefits, (2) personal benefits, (3) community exploitation, (4) personal risks, (5) convenience, (6) trustworthiness of the research team, (7) perceived value in donating, and (8) normalization of biospecimen collection. Participants were generally motivated to engage in biospecimen donation for altruistic purposes. The most cited concerns were related to data security, misuse, and privacy. Researchers must be proactive in building trust with Black and Hispanic/Latinx SGM communities to increase engagement, diversify biospecimen repositories, and reduce health inequities. Future research involving biospecimens should provide biospecimen education during the consent process and prioritize participant convenience.
Hermeneutics of Memory for Tourist Promotion: An Upcycling Process of Spanish Civil War Air Raid Shelters
Authors: Rosser Pablo , Soler Seila
Published: March 2024

This study delves into the transformative role of air-raid shelters from the Spanish Civil War in Alicante, Spain, highlighting their significance in the recovery and preservation of intangible heritage. Through a detailed hermeneutic analysis based on interviews and existing research, the investigation explores the shelters’ contribution to cultural identity, memory, and sustainable urban development. It reveals how the hermeneutics of memory, applied via a rigorous scientific approach, serves as a vital tool for justifying, rehabilitating, and planning these historical sites for tourism aligning with the Sustainable Development Goals. The rehabilitation of these shelters not only acts as a conservation effort but also as a means to promote cultural tourism enhancing Alicante’s cultural and tourist offerings. The study underscores the shelters’ dual role as educational resources and tourist attractions, facilitating a deeper understanding and connection with the past, and fostering community development and sustainability.
MAKNA REPRESENTAMEN KENDARAAN PADA FILM ANIMASI ANAK CAR TOONS COMPILATION: KAJIAN SEMIOTIKA C.S. PEIRCE
Authors: Astuti Soekma Yeni , W. Yanuaresti Kusuma
Published: March 2024

Car Toons Compilation is an animated film by the YouTube channel First Toons which contains a compilation of episodes of Car Toons, including A Tow Truck, A Water Truck, and A Tractor. Car Toons tells a different story in each episode but still includes car elements. This study aims to discuss the semiotic understanding of the animated film by using Peirce's semiotic theory, especially icons, indexes, and symbols. The method used in this study is a qualitative method with descriptive analysis, which emphasizes the process of semiosis with the meaning of the relationship between signs or representamen in the elements of animated films and their benefits for children. The study results show that the animated films A Tow Truck, A Water Truck, and A Tractor have imaginary icons, namely visuals based on similarities to reality. The Tow Truck's indexicality as a saviour for a breaking car has a symbol of a towing tool that has a tip like a fishing hook on the back of the truck. The indexicality of the Water Truck is used to save alive whales even though they are on land. The blue object is a symbol of water. Tractor truck indexicality that agricultural land can be planted due to tractor services, its symbolism is that the animation of land with plants is agricultural land. Based on this discussion, the meaning of representamen provides benefits for children in the form of understanding the types of trucks and their uses.
FALSAFAH MADURA DALAM NOVEL TANJUNG KEMARAU KARYA ROYYAN JULIAN: KAJIAN ANTROPOLOGI SASTRA
Authors: Sri Devi Maharani , Maslikatin Titik , Ramadhan Muhamad Abu Bakar , Aris Kartika Bambang , Angelina Dewi
Published: March 2024

The culture of an ethnic group can be known through its reflection in literary works. The Tanjung Kemarau novel by Royyan Julian tells about the complexities of the socio-cultural life of the Madurese people in Branta Pesisir Village, Pamekasan Regency, Madura. This study aims to describe the Madurese philosophy contained in the novel Tanjung Kemarau by Royyan Julian. The method used in this study is a qualitative method with descriptive analysis. This study uses the theory of literary anthropology to examine the main problem in the Tanjung Kemarau novel, namely the Madurese philosophy. The results of the study show that the Madurese philosophy reflected in the Tanjung Kemarau novel is abhântal sahâdât, smokepo' faith, apajung Èslam, (bearing creed, covered with faith, covered with Islam). Moreover, there are also found bhuppa', bhâbhu', ghuru, rato, (father, mother, teacher, and king or leader). The other phylosophy terms are abhântal ombâk, smokepo' angèn, apajung langngè', (cushioned by the waves, covered with wind, under the sky's umbrella) also Ango'an potèa tolang è tembhâng potè mata (better white bones than whites of eyes). Kar ngarkar colpè' (paw continuously pecking), Rampa' naong bâringèn korong (shady shady, banyan brackets) are stated in the novel. All the Madurese philosophy revealed in the novel describes the philosophy in the social reality of the Madurese people.
ANALISIS FRAMING PEMBERITAAN PEMBUNUHAN WANITA HAMIL DI GUNUNGKIDUL PADA MEDIA ONLINE REPUBLIKA.CO.ID DAN KOMPAS.COM
Authors: Hiranti Natasya Putri , Setiawan Hendra
Published: March 2024

This article discusses the framing analysis of reporting on pregnant women being killed in Gunungkidul in November 2022. The murder occurred because the victim RN (25) refused to abort her pregnancy as a result of her actions with ER (24). This study uses the Zhongdang Pan and Gerald M Koscki Framing Analysis model. This analysis model assumes that, every news has a frame that functions as the center of idea organization. The media studied are Republika.co.id and Kompas.com, both of which have views on how to package news. The data collection technique is the technique of observing and noting. The research data are textnews Republika.co.idq danq Kompas.com. The results of the research show that in packaging the news, these two media use simple words that are easily understood by the public. The two media have different points of view. Republika.co.id reports the chronology of the arrest of the two perpetrators of the murder by the police, while Kompas.com reports a number of heartbreaking facts in the case of the sadistic murder of RN.
ONOMATOPOEIA IN AVATAR “THE LAST AIR BENDER NORTH AND SOUTH”
Authors: Dwipayana Kadek Bara , Hikmaharyanti Putu Desi Anggerina
Published: March 2024

Comic is an image juxtaposed with other images in a sequence and make a story. The onomatopoeia word is used to build a story as well as for visual effects in comic stories. This study investigated onomatopoeia emerged in Avatar “The Last Air Bander-North and South” Comic Chapter 1. This study applied descriptive qualitative method. The data collection was carried out by using the observation through several stages, such as reading comics, highlighting the onomatopoeia found in comic, classifying onomatopoeia according to its type, and analyzing the meaning of onomatopoeia. This study used the theory from Bredin (1996) to determine the type of onomatopoeic word. On the other hand, the meaning of onomatopoeic words was analyzed using the theory from Thomas (1995). The results of this study indicated that three types of onomatopoeia found in comics, they were 32 (76%) direct onomatopoeia, 2 (5%) associative onomatopoeia, and 8 (19%) exemplary onomatopoeia. The meaning of onomatopoeic words contained in comics was included in abstract and contextual meaning.
BUSINESS STRATEGY, ACCOUNTING CONSERVATISM, TAX AGGRESSIVENESS
Authors:   Department of Design and Marketing, Tung Fang Design University, Kaohsiung, Taiwan, Yin Kuo Chen
Published: March 2024

Different from literature studying the bi-variable relation between business strategy and accounting conservatism as well as tax aggressiveness, this research provides original ideas exploring the relation among business strategy and accounting conservatism through tax aggressiveness. Using the Taiwan data including high-technology and traditional industries, our results indicate that first, prospector companies are more tax aggressive, and are more accounting conservative than defender ones. Secondly, the positive effect of business strategy on accounting conservatism holds through increasing tax aggressiveness (reducing tax payment), implying prospector companies with more tax aggressiveness are more accounting conservatism than defender ones with less tax aggressiveness. Thirdly, the positive effect of strategy on conservatism through increasing tax aggressiveness in high-tech firms is stronger than that in traditional ones. This implies that compared to traditional firms, high-technology firms can more strengthen this positive effect through tax aggressiveness. Fourthly, this paper highlights the role of tax aggressiveness in driving association between business strategy and conservative accounting. Finally, our results are analogous to Higgins et al. (2015) and Hsieh et al. (2019)’s findings of U.S. sample companies, implying that some characteristics of Taiwan companies (e.g., access to capital market, tax deductibility of investment in R&D) appear to be similar to particularities of U.S. firms. This paper provides the evidence on a developing country (Taiwan) for investors and portfolio managers.
Feldarchäologische Untersuchungen der ober- und unterfränkischen Burgställe Stufenburg, Windeck und Eltmann
Authors: Ziegler Britta
Published: March 2024

Die drei vorgestellten Burgställe Stufenburg, Windeck und Eltmann befinden sich in ähnlicher topografischer Ausgangslage auf bewaldeten Höhenzügen der Haßberge sowie des Steigerwalds. Obertägig nur durch die denkmalspezifische Topografie ihrer Wall-Grabensysteme gekennzeichnet, weisen alle drei Anlagen auch in geologischer und pedologischer Hinsicht gleichartige Standortparameter in Form des anstehenden Keupers sowie der podsoligen Braunerde auf. Die Burgen, obgleich unterschiedlicher Datierung, wurden nach ihrer Auflassung nahezu komplett zerstört: die Gebäude der Stufenburg und Burg Windeck sind erwiesenermaßen als Steinbrüche zur Gewinnung von Baumaterialien genutzt worden; die aus Holz, Erde und Trockenmauerwerk bestehende namenlose Burg im Eltmanner Bürgerwald ist seit ihrer Auflassung bis heute massiven Erosionsprozessen ausgesetzt. In allen Fällen blieben lediglich Zerstörungshorizonte zurück; nutzungszeitliche Befunde sind zumeist großflächig verloren gegangen und nur noch in geringfügigen Resten erhalten. In einem Zeitraum von neun Jahren wurden die Burganlagen durch den Lehrstuhl für Archäologie des Mittelalters und der Neuzeit der Otto-Friedrich-Universität Bamberg in mehreren feldarchäologischen Kampagnen geodätisch vermessen, geoelektrisch prospektiert und mittels minimalinvasiver Bodeneingriffe in Form von Hohlmeißelbohrungen und Sondageschnitten untersucht. Die vorliegende Arbeit setzt die jeweiligen geoelektrischen Messergebnisse in Korrelation zur Denkmaltopografie, zudem wird in zwei Fällen auch die im Untergrund vorhandene Stratigrafie einbezogen. Die zur Detektion archäologischer Schichtungen angewandten Methoden, hier Bohrungen und Sondageschnitte, eignen sich für spezifische Forschungsansätze: Mit dem Einsatz von Bohrungen zur Identifikation geoelektrisch abgebildeter Strukturen lässt sich ein schneller, kostengünstiger, wenn auch oftmals nur schlaglichtartiger Überblick über die stratigrafischen Verhältnisse einer Denkmalstätte ermitteln. Dagegen gewähren Sondageschnitte einen umfangreichen Einblick in die Befundsituation und ermöglichen die befundbezogene Bergung datierbarer Funde. Obgleich in zeitlicher, personeller und finanzieller Hinsicht erheblich aufwändiger als Bohrungen, ermöglichen Sondagen eine detailliertere Interpretation geoelektrischer Messungen und damit eine aussagekräftigere Ansprache der Befundsituation einer archäologischen Stätte. Ein weiterer Aspekt verbindet die hier vorgestellten Projekte über die Methodik hinaus: alle feldarchäologischen Maßnahmen waren als Kombination von universitärer und bürgerwissenschaftlicher Lehrveranstaltung konzipiert. Die Ergebnisse zeigen, dass die aktive Teilnahme von archäologisch interessierten Personen an universitären Forschungsprojekten sich nicht nur positiv auf das zu bewältigende Arbeitspensum auswirkt, sondern auch, bedingt durch einen nachhaltigen Wissenstransfer, eine öffentlichkeitswirksame Wissenschaftskommunikation generiert.
Deregulation of mitochondrial reverse electron transport alters the metabolism of reactive oxygen species and NAD+/NADH and presents a therapeutic target in Alzheimer’s disease
Authors: Rimal Suman , Li Wen , Khaket Tejender Pal , Li Yu , Tantray Ishaq , Li Yanping , Bhurtel Sunil , Grinberg Lea T , Spina Salvatore , Sillero Maria Inmaculada Cobos , Seeley William W , Guo Su , Lu Bingwei
Published: March 2024

Aim: Oxidative stress and NAD+/NADH imbalance caused by alterations in reactive oxygen species (ROS) and NAD(H) metabolism are pathological features associated with normal aging and age-related diseases including Alzheimer’s disease (AD). How abnormalities in ROS and NAD(H) metabolism occur under these pathological conditions is not well understood, nor is it known whether they are mechanistically linked and can be therapeutically targeted together. The aim of this study is to identify the cause of aberrant ROS and NAD(H) metabolism and test its role in the pathogenesis of AD.

Methods: Reverse electron transport (RET) along mitochondrial complex I can occur under certain thermodynamic conditions, leading to excessive ROS generation and NAD+ conversion to NADH, and thus lowered NAD+/NADH ratio. Brain samples from AD patients and mouse AD models were used to assess the status of RET by measuring ROS and NAD+/NADH ratio in brain lysates and purified mitochondria respiring under RET conditions. A small molecule RET inhibitor was used to treat APP(swe)/PS1(deltaE9) and 5xFAD mouse models and human induced pluripotent stem cell (iPSC)-derived neuronal model of AD. Effects on behavior and AD-related neuropathology were examined. The biochemical mechanism underlying RET alteration was examined by protein-protein interaction studies.

Results: RET is aberrantly activated in transgenic AD mouse brains and in individuals with AD. Pharmacological inhibition of RET reduced amyloid burden and neuroinflammation and rescued cognitive and behavioral deficits in the APP(swe)/PS1(deltaE9) and 5xFAD mouse models. In human AD iPSC-derived neurons, RET inhibition reduced amyloid aggregation, tau hyperphosphorylation, and early endosomal defects. Mechanistically, the AD-associated amyloid precursor protein C-terminal fragment (APP.C99) was found to interact with complex I proteins to promote RET.

Conclusion: RET is aberrantly activated in AD, causing altered ROS and NAD+/NADH metabolism. Pharmacological inhibition of RET is beneficial in mouse and human iPSC models of AD. RET activation represents a key pathological driver and a rational therapeutic target for AD and possibly other age-related neurodegenerative diseases.
Bentuk Kucing Sebagai Pola Hias Bingkai Cermin
Authors: A'ini Nikmah Nurul , Kurnia Panji
Published: March 2024

Dalam kehidupan sehari-hari bercermin merupakan salah satu kebutuhan manusia dalam memperbaiki tampilan diri, khususnya pada area wajah. Negara Indonesia merupakan negara yang memiliki beragam jenis kayu sebagai sumber kekayaan alam, salah satu diantaranya adalah kayu mahoni, sehingga tak heran jika kayu menjadi bahan utama sebagai pembuatan bingkai cermin yang ada di pasaran. Perkembangan budaya populer (kegiatan ber-make up) yang telah menjadi tren dalam kehidupan perilaku kaum remaja di Indonesia mendorong penulis menciptakan suatu karya fungsional dan memiliki nilai estetis sebagai benda pelengkap dekoratif berupa cermin hagging, yang dikhususkan untuk para remaja puteri usia 20 -27 tahun ketika melakukan make up. Bentuk silhouette tubuh kucing jenis Felis Silvetris Catus atau kucing kampung dipilih sebagai bentuk visual pola bingkai cermin, karena dalam islam hewan kucing memiliki keistimewaan sebagai hewan kesayangan Nabi Muhammad SAW.
Treatment of Adult Distal Humerus Fracture with Fishtail Deformity
Authors: Joseph Elias G , Gardner Warren E
Published: March 2024

Case:

We report a single case of a closed intra-articular distal humerus fracture in a 28-year-old man with a preexisting fishtail deformity characterized by concavity of the central trochlea and corresponding deformity of the olecranon. The patient was treated with open reduction and internal fixation.

Conclusion:

The case highlights the diagnosis and challenges of treatment. Conventional fixation choices and imaging techniques may need to be altered when treating a fracture with this deformity.
Islas de Calor Urbanas y sus vínculos territoriales con el sistema urbano y sociodemográfico de la Región Centro de México
Authors: Rosas Villar Israel , Pérez Campuzano Enrique
Published: March 2024

La Región Centro de México concentra una porción importante de la población, de ciudades del sistema urbano y del aparato productivo del país. Su dinámica altera la temperatura en las ciudades, y abre paso a microclimas (identificados a través de las Áreas Geoestadísticas Básicas) que se caracterizan por la presencia de Islas de Calor Urbanas que repercuten en las actividades. En la investigación se adopta la metodología de estadística espacial como el Índice de Moran y el Modelo de Rezago Espacial para analizar la estructura urbana y demográfica asociada a la variabilidad territorial de la temperatura promedio a través de estaciones meteorológicas. Los resultados señalan que las Islas de Calor Urbanas parten de las zonas metropolitanas o los centros de población hacía la periferia urbana de forma radial y asimétrica. Así mismo, su presencia está asociada a las viviendas particulares habitadas que cuenten con servicios de electricidad, refrigerador, computadora e internet; infraestructura vial, morfología urbana, manufactura, deforestación y altitud. Además, se contribuye a la comprensión de las Islas de Calor Urbanas con técnicas no convencionales como la estadística espacial, representación cartográfica y una escala territorial detallada.
Highly scalable multiplex serology by mass spectrometry analysis of beads
Authors: Drainas Alexandros P. , Rovira-Clavé Xavier
Published: March 2024

Serology testing is crucial for diagnostics and epidemiological surveillance. Traditional methods test one antigen at a time and are costly at large scale implementation. Here, we introduce a scalable, cost-effective, and multiplex serology immunoassay that uses mass cytometry to analyze polystyrene beads loaded with stable isotopes. Our approach can generate 18,840 unique barcoded beads and enables high-throughput detection of antibodies in small volumes of plasma. This scalable method allows simultaneous analysis of IgG and IgM levels across hundreds of samples, offering a significant advance to the multiplex capabilities of serology immunoassays.
Outcomes of smart glasses: Protocol for a systematic review and meta-analysis
Authors: Motahari-Nezhad Hossein , Sadeghdaghighi Aslan , Salmani Hosna
Published: March 2024

Smart glasses have revolutionized healthcare delivery with their hands-free functionality, voice command operation, and ability to project data onto lenses. This protocol outlines a systematic review and meta-analysis to assess the outcomes of smart glasses in healthcare. Following PRISMA-P guidelines, this review will include peer-reviewed English randomized controlled trials (RCTs) comparing smart glasses to non-smart glass interventions across diverse patient populations and settings. Exclusion criteria comprise non-RCTs, non-peer-reviewed resources, and studies where smart glasses are not the primary intervention. The search, conducted in PubMed, Scopus, and the Web of Science, without time limitations, will be systematically managed and documented, including the selection process, represented through a PRISMA flow diagram. Data extraction will cover key study characteristics and outcomes. Risk of bias will be assessed using the ROB 2 tool. Studies with comparable outcomes will be pooled for meta-analysis, employing the DerSimonian and Laird method in R software, with heterogeneity assessed via the I-squared statistic. A meta-regression analysis will explore age-related heterogeneity, and subgroup analysis will investigate bias risk levels. Publication bias will be assessed using the Trim and Fill technique and Egger and Begg tests. The outcomes' quality will be evaluated using the GRADE framework. The findings are expected to guide future research, influence health policy, and inform healthcare professionals and policymakers about integrating smart glasses into healthcare systems.
Enhancement of land subsidence prediction capabilities using machine learning and SHAP value analysis with Sentinel-1 InSAR Data
Authors: Su Heng , Xu Tingting , Xion Xiancai , Tian Aohua
Published: March 2024

Land subsidence has been a significant focus of geoscience studies, and researching the factors contributing to it and predicting future incidents is essential. However, current research requires a systematic and coherent strategy to identify symptoms of land sinking with scientific rigor. This study employs neural networks and SHAP values to forecast land subsidence. We utilized SHAP values as a substitute for the usual random forest (RF) technique to evaluate the attributes of land subsidence. In addition, we employed neural networks to predict the prospective areas where land subsidence may occur in Chongqing and Chengdu in the future, considering a diverse set of conceivable situations. The results indicate that using neural networks for land subsidence prediction improves the model's accuracy by 16% compared to the traditional approach. The performance is enhanced by approximately 22% after optimizing the input characteristics. The feature optimization strategy proposed in this study, which relies on SHAP values, is particularly advantageous for predicting land subsidence. Moreover, the determinants of land sinking, ascertained by data analysis considering intricate topography, correspond with the conclusions of previous research. Utilizing this feature optimization method can improve the selection of input variables for the land subsidence prediction model, increasing accuracy and providing a solid theoretical foundation for preventing urban land subsidence.
Opposing Roles of Akt isoforms in intestinal epithelial integrity, inflammation and cell renewal: therapeutic implications or Inflammatory Bowel Disease.
Authors: Prieto Teresa García , Barbachano Antonio , Cuesta Natalia , Sánchez María Dolores , Arranz Alicia , Fresno Manuel
Published: March 2024

Background
Akt1 and Akt2 genetic deficiency in mice have a role in inflammatory bowel disease development, but the mechanism of action is not yet fully understood.
Methods
Akt (Protein Kinase B) isoform-specific inhibitors were assayed in mouse colon organoids and in a mouse model of colitis induced by dextran sulfate sodium. Mice were monitored in real time for clinical signs including colonoscopy. Inflammation and colon structure were analyzed using immunohistochemistry and PCR. Permeability was assessed through transepithelial electrical resistance assays, and the expression of tight junction protein and βCatenin was analyzed using western blot and immunofluorescence in various epithelial cell lines with specific overexpression or inhibition of Akt isoforms.
Results
In the mouse model of IBD (Inflammatory Bowel Disease) induced by dextran sulfate sodium, the inhibition of Akt2 strongly ameliorates disease with animals exhibiting healthy-like crypts, tight colon epithelial cells expressing tight junction proteins, and presenting an anti-inflammatory M2 macrophage phenotype. Conversely, treatment with Akt1 inhibitors exacerbated histological damage, with disorganized tight junction proteins, reduced Lgr5+ expression, and promoted a more pro-inflammatory environment, further favoring disease development. Akt1 was expressed in healthy colon whereas Akt2 expression was associated with diseased epithelia. Mouse intestinal organoids treated ex vivo with Akt1 inhibitors exhibited disassembled and disorganized structures that mimic the histological features of IBD. Notably, overexpression of Akt1 or chemical inhibition of Akt2 on intestinal epithelial cells, had similar effects increasing the permeability of the epithelial barrier and affecting the expression and/or intracellular localization of tight junction proteins. In contrast, inhibition of Akt1 or overexpression of Akt2 showed opposite results. Overexpression of Akt1 or inhibition of Akt2 also promoted activation of βCatenin and Lgr5.
Conclusions
The results suggest that a balance between Akt1 and Akt2 regulates the functionality of the intestinal epithelial barrier, cell renewal and inflammation which affects the development of the disease. Thus, Akt2 inhibition can be considered as a new therapy for inflammatory bowel disease.
Efficacy of First-line Therapy With Anti-EGFR Versus Anti-VEGF Therapy for WT RAS Metastatic Colorectal Cancer: Real-world Experience from a Single Institute
Authors: Chiang Shih-Wei , Huang Yi-Lin , Chiang Feng-Fan , Chen Ming-Cheng
Published: March 2024

Background/Aim:
Top prospective clinical trials comparing anti-epidermal growth factor receptor (EGFR) therapy and anti-vascular endothelial growth factor (VEGF) therapy plus chemotherapy for wild-type Ras proto-oncogene, GTPase (WT RAS) metastatic colorectal cancer (mCRC) have yielded different outcomes, and real-world data are lacking. This study established real-world experiences and identified challenges in treating patients with mCRC.
Patients and Methods: This retrospective study identified first-line regimens for patients with mCRC on anti-EGFR or anti-VEGF therapy plus chemotherapy. The effects on overall survival (OS) were estimated; secondary endpoints were progression-free survival (PFS). OS in the two groups was compared on the basis of sex, age, primary tumor site, oxaliplatin-based chemotherapy, and number of organs with metastases through Cox multivariate regression analysis. Results: A total of 129 patients diagnosed with WT RAS mCRC from June 1, 2018, to December 31, 2021, were included. The median OS was 33.3 months for the anti-EGFR group (n = 78) and 26.1 months for the anti-VEGF group (n = 51; 95% confidence interval = 1.008–2.550; p = 0.044). PFS was 17.6 and 12 months, respectively (95% confidence interval = 0.9-1.963; p = 0.15). Multivariate Cox regression models revealed good OS for patients with WT RAS and left-sided primary tumor. The liver-only metastasis conversion rate after systemic chemotherapy was higher in the anti-EGFR group.
Conclusion: High survival rates can be achieved when anti-EGFR is used in patients with WT RAS mCRC. Surgery still plays an important role in patients with mCRC and on systemic treatments.
Proposal for a UAV-Integrated Manipulator-Based System for Capturing Animals with Anesthesia: Simulation and Experimental-Based Validation
Authors: Cabuk Nihat
Published: March 2024

In this study, a model was proposed for performing remote anesthesia on animals using a quadrotor unmanned aerial vehicle (UAV). The proposed model integrates a manipulator into the UAV, and a mechanism system for throwing an anesthesia needle was mounted on this manipulator. A solid model of the entire proposed system was created, and a mathematical model of the system was developed. The validity of the proposed model was verified by examining the system parameters through simulation studies based on this mathematical model. Two different scenarios were constructed in the simulations. In the first scenario, the system locked on the target for a fixed position, while the second scenario was on a target that is in motion in all three dimensions. In both simulations, the UAV flew autonomously along a predetermined trajectory. The results obtained were presented graphically. In addition, the system for which a solid model was created was produced and preliminary tests were carried out in the outdoor environment. It has been shown that this proposed system can be used in a real environment.
Contribution of alcohol use and smoking to the global burden of atrial fibrillation from 1990 to 2019 and projections to 2044
Authors: Wei¹ Yinze , Wang² Zhen , Chen² Miao , Ma Liang
Published: March 2024

Background The prevalence of atrial fibrillation has quadrupled in the last few decades. With socio-demographic issues such as ageing becoming more prominent, the soaring healthcare costs associated with AF treatment suggests that we are facing a major public health issue. In 2019, with 4.7 million cases of AF/heart failure and more than 300,000 related deaths, China led the world in the number of incident cases, cases of DALYs, and deaths are the highest in the world.Methods Based on the Socio-Demographic Index (SDI), 204 countries and territories can be categorised into five regions, including low, medium, intermediate, high and high. Considering geological consistency, these countries and areas can be divided into 21 regions.Result In 2019, there were more than 20,000 (95% IU, 0.17–0.29) AF deaths due to alcohol consumption, accounting for 30% of all AF deaths. The corresponding age-standardised death rate (ASDR) declined by 0.126% per year(95% UI, -0.193 to -0.059) from 1990 to 2019 (Table 1). In the same year, there were 730,000 (95% UI, 5.1 to 10.1) DALYs for AF due to alcohol consumption globally.Conclusions It is fortunate that there is no clear exponential rise in AF resulting from global alcohol and tobacco use, and the primary burden is found in countries with medium to high socio-demographic indices. While there is a gradual increase in deaths and DALYs caused by alcohol and tobacco use worldwide, ASDR and age-standardised DALY rates are marginally decreasing.
Chemical ordering and magnetism in face-centered cubic CrCoNi alloy
Authors: GHOSH SHEULY , Ueltzen Katharina , George Janine , Neugebauer Jörg , Körmann Fritz
Published: March 2024

The impact of magnetism on chemical ordering in face-centered cubic CrCoNi medium entropy alloy is studied by a combination of ab initio simulations, machine learning potentials, and Monte Carlo simulations. Large magnetic energies are revealed for some mixed L12 /L10 type ordered configurations, which are rooted in strong nearest-neighbor magnetic exchange interactions and chemical bonding among the constituent elements. There is a delicate interplay between magnetism and stability of MoPt2 and L12 /L10 type of ordering which may explain opposing experimental and theoretical findings.
Constant Force Grinding Controller for Robots Based on Soft-Actor-Critic Optimal Parameter Finding Algorithm
Authors: Rei Chosei , Wang Qichao , Chen Linlin , Yan Xinhua , Zhang Peng , Fu Liwei , Wang Chong , Liu Xinghui
Published: March 2024

Since conventional PID (Proportional-Integral-Derivative) controllers hardly control the robot to stabilize for constant force grinding under changing environmental conditions, it is necessary to add a compensation term to conventional PID controllers. An optimal parameter finding algorithm based on SAC(Soft-Actor-Critic) is proposed to solve the problem that the compensation term parameters are difficult to obtain, including training state action and normalization preprocessing, reward function design, and targeted deep neural network design. The algorithm is used to find the optimal controller compensation term parameters and applied to the PID controller to complete the compensation through the inverse kinematics of the robot to achieve constant force grinding control. To verify the algorithm's feasibility, a simulation model of a grinding robot with sensible force information is established, and the simulation results show that the controller trained with the algorithm can achieve constant force grinding of the robot. Finally, the robot constant force grinding experimental system platform is built for testing, which verifies the control effect of the optimal parameter finding algorithm on the robot constant force grinding and has specific environmental adaptability.
Tau aggregation induces cell death in iPSC-derived neurons
Authors: Tanabe Hirokazu , Maeda Sumihiro , Sano Etsuko , Sakai Norio , Endoh-Yamagami Setsu , Okano Hideyuki
Published: March 2024

Abnormal accumulation of tau proteins in the brain is observed in neurodegenerative diseases such as Alzheimer’s disease and is closely associated with neuronal cell death. However, the mechanism by which tau causes neuronal cell death remains unclear, and the establishment of a drug discovery model for tau-related neurodegenerative diseases is expected. In this study, we investigated the establishment of a cellular model of tau aggregation and cell death in human iPSC-derived neurons to observe tau-dependent cell death. Tau overexpression in iPSC-derived neurons resulted in cell death through tau aggregation. In addition, we confirmed that compounds exhibited neuroprotective effects. These findings suggest that this cellular model has a property of the molecular pathogenesis of tau-induced neurodegeneration.
The diagnostic value of combined detection based on heparin-binding protein in septic patients
Authors: Feng Liwei , Liu Shujie , Wang Jieying , Gao Yan , Xie Fengjie , Gong Jianguo , Bi Sheng , Yao Zhipeng , Li Yue , Liu Wenhua , Guan Chunming , Zhang Ming , Wang Hongliang , Zheng Junbo
Published: March 2024

Background Although plenty of biomarkers have been identified, prediction and diagnosis of sepsis is still challenging in the worldwide. As a novel biomarker, heparin-binding protein (HBP) released from neutrophils may induce inflammatory responses and worsen vascular permeability, which presents the physiopathologic characteristics of sepsis and septic shock. We hypothesized that combined measurements based on HBP will enhance the diagnostic efficiency of HBP and is even better than the traditional infection markers. Methods A multi-center observational cohort study between July 2021 and June 2022 at eight tertiary hospitals in Heilongjiang was performed. Enrolled patients were classified into three groups based on infection severity, including non-sepsis, sepsis and septic-shock. Clinical and laboratory data, infection and inflammation biomarkers were collected for analysis. Results A total of 195 patients were enrolled. Of the three groups classified, patients with septic shock (n = 75, 38.5%) had significantly increased levels of HBP, WBC, Lac, CRP, PCT, IL-6, IL-8 and IL-10 compared to non-sepsis (n = 43, 22.0%) and sepsis patients (n = 77, 39.5%) at baseline, as well as 28-d mortality (p < 0.05). Serum concentrations of HBP, Lac, IL-6, IL-8 and IL-10 were remarkably decreased in septic shock patients after 3 d (p < 0.05). Compared to SOFA score and classical markers of CRP, PCT, IL-6 and IL-8, the combined indexes of IL-6·IL-8·HBP and IL-6·IL-8·HBP/ALB showed significantly better performance in the diagnosis of sepsis and septic shock (AUC 0.911 and 0.902 respectively, p < 0.001). Conclusions Combination measurements of IL-6·IL-8·HBP and IL-6·IL-8·HBP/ALB can enhance the diagnostic abilities of HBP for septic diagnosis, and provide early reliable supplements to classical biomarkers for assessment of illness severity in infection patients.
Study of defect density of copper vacancies in Chalcogenide CuSbS2, CuSbSe2, CuBiS2 and CuBiSe2 heterojunction thin film Solar Cells
Authors: Lal Shankar , Rathore Sushila , Patel Kinjal , Ray Jaymin , SHARMA SHYAM SUNDER
Published: March 2024

In the past decade, a new family of ternary chalcogenide absorber (TCA) materials MIMIIX2 (where, MI= Cu, Ag, Pb, MII =Sb, Bi, In and X=S, Se, Te) have studied. The Copper family of ternary chalcogenide CuSbS2 CuSbSe2 CuBiS2 and CuBiSe2 are amazing absorber materials for thin film solar cells due to their suitable band gap, high absorption coefficient, inexpensive, nontoxic, sustainable and environment friendly. In this paper, simulated copper vacancies defect density of CuSbS2 (CAS), CuSbSe2 (CASe), CuBiS2 (CBS) and CuBiSe2(CBSe) based heterojunction thin film solar cells (HJTFSC) with buffer CdS, intrinsic i-ZnO, window ZnO: Al and back contact Mo, and set the cell scheming ZnO: Al/i-ZnO/n-CdS/p- TCA/Mo. Major focus of influence of copper vacancies defect density impact on the performance of ternary chalcogenide with various parameters of solar cells i.e., short circuit current density (Jsc), open circuit voltage (Voc), form factor (FF) and efficiency (η). The cell parameter set at constant temperature 300K, thickness 2.5mm, carrier density 5x1016cm-3, front internal transmission coefficient 1, reverses voltage across L-R -1Vand illumination intensity 100 mW/cm2with AM1.5 sun light.
Hazard assessment of debris flow disaster induced by Tianchi outburst in Changbai Mountain
Authors: Liu Peng , Lang Qiuling , Zhang Yichen , Zhang Jiquan , Huang Jintao
Published: March 2024

The frequent occurrence of debris flow disasters in the Chibei District of the Changbaishan Mountain Reserve has seriously affected the lives and properties of residents.This paper, the MIKE21 model was used to simulate the distribution area and maximum water depth after the water body collapse in Changbaishan Tianchi. According to the specific conditions of the study area, eight evaluation indicators were selected: maximum water depth, average annual rainfall, slope, aspect, curvature, vegetation cover, lithology, and distance to water system. The study adopts game theory to optimize the combination of two empowerment methods of network hierarchy analysis (ANP) and CRITIC. It comprehensively evaluates the disaster hazard of debris flow induced by the Changbaishan Tianchi outburst based on a geographic information system. The results showed that 27.5% and 11.8% of the study areas were high and very high-risk, respec-tively. The receiver operating characteristic curve (ROC) was used to verify the accuracy of the mudslide hazard evaluation model. The accu-racy of the results reached 92%, indicating that the results of the hazard zoning are in line with re-ality. The assessment results can provide primary research for assessing debris flow disaster risk and early warning in the Changbaishan mountain area.
LncRNA BRE-AS1 Regulates the JAK2/STAT3-mediated Inflammatory Activation via the miR-30b-5p/SOC3 Axis in THP-1 cells
Authors: Shin Jae-Joon , Suk Kyoungho , Lee Won-Ha
Published: March 2024

Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators in numerous biological processes, including macrophage-mediated inflammatory responses, which play a critical role in the progress of diverse diseases. This study focuses on the regulatory function of lncRNA BRE-AS1 in modulating the inflammatory activation of monocytes/macrophages. Employing the THP-1 cell line as a model, we demonstrate that lipopolysaccharide (LPS) treatment significantly upregulates BRE-AS1 expression. Notably, specific knockdown of BRE-AS1 via siRNA transfection enhances LPS-induced expression of interleukin (IL)-6 and IL-1β, while not affecting tumor necrosis factor (TNF)-α levels. This selective augmentation of pro-inflammatory cytokine production coincides with increased phosphorylation of JAK2 and STAT3. Furthermore, BRE-AS1 suppression results in the downregulation of SOCS3, an established inhibitor of the JAK2/STAT3 pathway. Bioinformatics analysis identified binding sites for miR-30b-5p on both BRE-AS1 and SOCS3 mRNA. Intervention with a miR-30b-5p inhibitor and a synthetic RNA fragment that represents the miR-30b-5p binding site on BRE-AS1 attenuates the pro-inflammatory effects of BRE-AS1 knockdown. Conversely, a miR-30b-5p mimic replicated the BRE-AS1 attenuation outcomes. Our findings elucidate the role of lncRNA BRE-AS1 in modulating inflammatory activation in THP-1 cells via the miR-30b-5p/SOCS3/JAK2/STAT3 signaling pathway, proposing that manipulation of macrophage BRE-AS1 activity may offer a novel therapeutic avenue in diseases characterized by macrophage-driven pathogenesis.