bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on the Regulation of Human Rights Responsibility of Multinational Companies
Authors: Su Haoyu
Published: September 2023

With the development of economic globalization, the status of multinational corporations is constantly improving. Multinational corporations play an increasingly important role in promoting global economic development, profoundly influencing the development of the global economic and political landscape. While promoting economic development, transnational corporations also violate human rights, such as squeezing labor, polluting the environment, and endangering the right to life, health and development of the people in the host country. In this context, analyzing the human rights issues of multinational corporations is important. The article adopts case analysis, historical analysis, and literature analysis methods to analyze the human rights responsibilities of multinational corporations, The article explores the definition, origin, and theoretical basis of human rights responsibility of multinational corporations, as well as the reasons for their human rights violations. At the same time, suggestions are proposed from international regulations, host countries, home countries, and enterprises themselves to regulate the human rights violations committed by multinational corporations, promoting them to actively assume human rights responsibilities.
The theoretical understanding and strategic measures of the functional value of State-owned enterprises in the new era
Authors: Liao Jianhui , Xiao Hanxiong , Wang Yu
Published: September 2023

The current global economic practice can tell us that national competition is the underlying structure of global market competition, innovation is the core factor to create the competitive power of dominant enterprises in the global market and dominates the global income distribution. However, when market competition will reshape the distribution pattern, the global market governance will fail. In this context, Chinese state-owned enterprises, due to their extensive layout and advantages, need to take greater responsibility in innovation and other aspects. To this end, we need to adhere to market-oriented reform, take core technological innovation as the key grasp, and fully follow the commercial orientation to give full play to the incentive compatibility role.
Opening to the outside world, Industrial upgrading and Labor market integration: An empirical study of Chinese data from the perspective of enterprise ownership structure
Authors: Tan Yanting
Published: September 2023

Based on the panel data of 31 provinces in China from 2011 to 2020, this paper studies the impact of opening to the outside world on labor market integration under the mechanism of industrial structure upgrading from the perspective of enterprise ownership structure. The findings are as follows: (1) the increase in opening to the outside world significantly reduces the average wage gap and employment gap between state-owned and non-state-owned sectors, which contributes to the integration of the Chinese labor market; (2) The level of opening to the outside world has a significant effect on the upgrading of industrial structure, industrial upgrading is a mechanism of opening to the outside world affecting our labor market integration; (3) The effect of the level of opening to the outside world on labor market integration has obvious regional characteristics. The findings of this paper have important implications for understanding the relationship between opening to the outside world and labor market integration from the perspective of different enterprise ownership structures and the mechanism of industrial structure upgrading.
Brexit's impact on European integration
Authors: Wu Yuze
Published: September 2023

Europe, the birthplace of modern civilization, has gone through thousands of years of change and war, and is still the focus of world politics, economy, and technology today. With the creation of the European Union, the concept of European integration has returned to public discussion. In recent years, Brexit has caused an impact on the theory of European integration, and the previous scholars' research on the theory of integration has been almost completely subverted. Based on previous studies on the theory of European integration, this paper analyzes from the perspectives of politics, economy, diplomacy and geopolitics to study what impact and influence Brexit will bring to the European integration.
A Study of the Impact of Chinese Aid to Cambodia on Bilateral Trade
Authors: Kang Ziwei
Published: September 2023

Since the "Belt and Road" initiative was put forward, the scale of China's foreign aid has grown rapidly and the scope of radiation has been expanding. Foreign aid has become one of the tools of China's foreign relations that cannot be ignored, and it is especially important to study the bilateral trade effects brought by foreign aid. This paper mainly selects the impact of China's aid to Cambodia on bilateral trade for research. This study adopts the trade gravity model, introduces GDP and population size as control variables, and conducts regression analysis on the amount of China's aid to Cambodia and bilateral trade over the years, and concludes that China's aid to Cambodia helps to promote bilateral trade.
The Relationship Between Money Supply and Price Movements from A Structural Perspective
Authors: Chen Binbin
Published: September 2023

This paper examines the impact of money creation and flow on prices, including house prices and financial asset prices, from a structural perspective. By analyzing central bank monetary statistics, the study highlights the relationship between money supply and price changes, emphasizing long-term effects on consumer prices and short-term effects on incremental household deposits. Furthermore, the study emphasizes the importance of monitoring changes in the money supply, both domestically and internationally, with specific attention to the PPI (Producer Price Index) changes. The real estate market is identified as a significant driver of money creation, particularly through deposits in non-bank financial institutions. Additionally, deposits in non-bank financial institutions are found to be an important indicator of stock market volatility. The paper recommends that asset prices be included as a key target of monetary policy and advocates closely monitoring trends in international commodity prices.
Strategic Management Analysis of Haidilao
Authors: Shu Kexin
Published: September 2023

In recent years, with the economic and social development, the development momentum of the catering industry continues to be hot, and at the same time people's consumerism and other major changes are also taking place. And in 2020 China's catering industry by the impact of the new crown virus, the development of a serious obstacle, the competition is more intense. The development strategy of catering industry enterprises has become a problem that deserves attention. As a successful model in the catering industry, Haidilao Company enjoys a high reputation among the crowd, but it also faces some development difficulties. This paper takes Haidilao Co., Ltd. as the research object, firstly introduces Haidilao's company profile and current development strategy, and analyzes the enterprise's strategic management method using Porter's Five Forces model and SWOT analysis method. Finally, according to the analysis of the content of this paper puts forward to promote product innovation, strengthen the diversification of development, strengthen the quality management and strengthen the construction of corporate culture and talent training and other recommendations, hoping to provide a certain reference for the Haidilao or catering industry practitioners.
The Influence of Ukiyo-e on Modern Illustration
Authors: Shi Yanqiu , Zhou Hao
Published: September 2023

Ukiyo-e is an art form that was developed during the Edo period in Japan, depicting mainly the culture of the Japanese marketplace, as well as places of entertainment and landscape scenery. Ukiyo-e had a great impact on European painting and influenced the creation of a large number of people, including the Impressionists, and gave European art a new look. Ukiyo-e's lines, composition, colors, and choice of materials not only profoundly influenced Western art, but also the creation of modern illustration, and traces of Ukiyo-e can be seen everywhere in modern illustration works.
The Art Form of Dragon Patterns on Jade Wares from the Tomb of the Marquis of Jin in Shanxi
Authors: Zhao Xiaoli
Published: September 2023

The dragon patterns carved on the jade wares of the Marquis of Jin Dynasty are all extremely ingenious, with vivid shapes and exquisite patterns. It presents the magnificent jade culture of the Jin Dynasty in the Western Zhou Dynasty to the world, and provides valuable information for future generations to study the dragon patterns on the jade articles of the Zhou Dynasty.
On Chinese Aesthetics of Abstract Expressionism Art
Authors: Zhang Xiaotong
Published: September 2023

In the development trend of modern and contemporary art, abstract expressionism has occupied a decisive position in the history of art since its birth. As a representative art school in the 20th century in the West, it unexpectedly has a very distinctive artistic characteristic of China. In terms of objective environment, the artistic dialogue between China and the West in the 20th century was promoted to the field of metaphysical philosophy. Western artists' interest in oriental art surpassed their superficial understanding of their unique brushwork, and abstract art became the best cultural bridge to communicate between the East and the West. This paper compares the characteristics of Chinese and western artistic thoughts and the characteristics of abstract expressionism art, and explains how it has oriental artistic thoughts on the basis of world outlook.
Characteristics of Colour Expression in Modernist Art
Authors: Pan Jing , Pi Qing , Guo Miao , Guo Zidi
Published: September 2023

The expression of colour has a special role in modern aesthetics, with psychological factors and emotional components. The characteristics of colour are directly related to the personality, concept and artistic background of modern artists. Studying the special charm of colour from the perspective of its production, its expression, its artistic nature and its psychological characteristics, we can discover the distinctive characteristics of colour expression in modern art and the great visual impact it brings.
Analysis of the Importance of Statistical Methods for Art Design
Authors: Deng Juqing
Published: September 2023

Based on the differences between statistics and art design, and through the intersections of its application and service fields, This paper expounds the importance of statistical methods to artistic design from five aspects: data collection method makes artistic design have a broad market base, quantitative analysis method makes artistic design have a clear direction, qualitative analysis method makes artistic design more profound and efficient, variable analysis method makes artistic design more creative and breakthrough, and dialectical unity of quantitative and variable makes artistic design more vital. It is proved that statistical methods can make artistic design products more scientific and targeted in the process of design and development, and can provide a guarantee for them to better open their minds, achieve breakthroughs and reflect social values.
Postmodernism and Logo Design: Take the Memphis Style as an Example
Authors: Wang Yiyuan
Published: September 2023

In the context of the post-industrial era, the comprehensive development process of transforming the design purpose into a design concept is particularly prominent in terms of breadth and depth of the impact on product design. Its postmodernism aims to better adapt to the material foundation and spiritual needs of human spiritual and cultural development, and between manufacturing and design. the intersection of the product is the core, so that the performance between the product and the design becomes more and more profound. Using the literature research and analysis method, the comparative research method is used to analyze the changes in the performance of art symbols in postmodernism and summarize the expression methods of Memphis design. The humanization, diversification, personalization, color, etc. of the performance have the characteristics of Memphis style, which fully reflects the needs of human life diversity. The pursuit and performance are also in line with the characteristics of the popularization of art ubiquitous in society. At the same time, the logo performance constantly draws on and adopts the orthogonal spirit of humanism, which closely combines traditional art theory and real cultural life, and closely combines the theory of traditional art with the actual life of modern art, so as to fully oppose Reflecting the pursuit of the universal life of mankind and the increasing needs of social material civilization and real cultural survival.
Derrida's Thinking on the Phenomenon of Blindness
Authors: Chen Qing
Published: September 2023

The issue involved in this article is the advancement of the French philosopher Jacques Derrida on the modern problem of “Invisible” through the topic of "blindness". For one thing, Derrida continued Merleau-Ponty's discussion about the invisible and emphasized an absolute invisibility; for another thing, he turned the invisible to the ethical issue, and this is also the change from recognition to gratitude. There are four aspects involved in this process: mirror without image, intentionality without vision, the essence of the eyes, and the suspension of reason.
Visual Transformation of Textile Intangible Cultural Heritage Patterns in the Design of Cultural and Creative Products
Authors: Zhang Ying , Han Xiaoshi
Published: September 2023

Based on the market status of the application of textile intangible cultural heritage in cultural and creative products, this paper analyzes the innovative design of contemporary textile intangible cultural heritage. This paper discusses the innovative design concept of textile intangible cultural heritage and creative products, analyzes the visual transformation principles of textile intangible cultural heritage in the design of cultural and creative products, and explores new ideas for intangible cultural heritage and creative design from three aspects: cultural, innovative and functional, in order to benefit the research field of textile intangible cultural heritage and creative product design in China.
Traditional Chinese Mythology in Animation Art
Authors: Zhao Yiming , Zheng Dongfang
Published: September 2023

Chinese traditional myths, as an important part of Chinese culture, have been widely applied and expressed in animation art. From the perspective of animation art, this paper will discuss in depth the expression forms and expression methods of traditional Chinese myths in animation art, including the use of myth elements in animation, the creation of myth characters, the way of narrating myth plots, and the expression of myth meanings. Through analyzing and comparing related animation works, this paper will explore the performance characteristics of Chinese traditional myths in animation art and its relationship with contemporary animation art, so as to provide reference for the inheritance and development of Chinese traditional culture.
Research on the Application of Visual Elements of Intangible Cultural Heritage in the Design of Contemporary Cultural and Creative Products
Authors: Han Xiaoshi , Zhang Ying
Published: September 2023

The rapid development of global cultural creativity has made local culture and regional culture advocated, and intangible cultural heritage containing unique cultural genes and cultural values has become an important source of cultural creative design. Nanjing is a famous cultural city with a history of more than 2,500 years, rich in culture and art, and its wide variety of intangible cultural heritage with distinctive characteristics is also remarkable, which can become a creative source of cultural and creative products. The application of cultural elements from Nanjing's intangible cultural heritage to the design of cultural and creative products can enhance the cultural connotation and cultural uniqueness of products, and also provide new ideas for the inheritance of Nanjing's intangible heritage in modern society. Based on the premise of Nanjing's intangible cultural heritage, velvet flowers, this paper focuses on the application of intangible cultural heritage in the design of cultural and creative products. Firstly, the background, definition, attributes, and design status of cultural and creative products are analyzed. Secondly, the design principles and application methods of intangible heritage, velvet flowers, in cultural and creative products are summarized, and the extraction and transformation methods of cultural elements in the design of cultural and creative products are proposed. Then, the characteristics and value of Nanjing velvet flowers are summarized, and the feasibility of cultural and creative products as the inheritance path of Nanjing velvet flowers is discussed through the analysis of the current situation of Nanjing velvet flowers. Finally, the design practice of Nanjing velvet flower is carried out as an example to promote the inheritance and development of Nanjing's intangible cultural heritage.
Application of Gestalt Psychology Principle in Decorative Film
Authors: Wu Wenhua
Published: September 2023

This paper takes the principle of Gestalt psychology and decorative film as the research object, through analyzing the practical needs of decorative film pattern design, and discusses the principle of Gestalt psychology, similar principle, similar principle, closed principle, continuous principle, subject and background relationship, symmetry principle, etc., analyzes the application design of Gestalt psychology principle in decorative film pattern. Therefore, to get the physiological and psychological characteristics of visual perception is the only way to design patterns that conform to the law of human cognition.
Turquoise Town under the Perspective of Cultural Revitalization Brand Building Research
Authors: Chen Ye , Li Shangyang , Zheng Zewei
Published: September 2023

The biggest difference between characteristic towns and ordinary towns lies in the grasp of their own cultural characteristics and the cognition of the key factors of sustainable development. Therefore, for the turquoise town in Zhushan County, Hubei Province, we should take the excavation and integration of turquoise town cultural resources and the application as the top priority of planning and construction, and build the town into a multi-cultural feature with resources, localization, creativity and experience, so as to overcome the limitation of non renewable Turquoise and promote the sustainable development of the town.
Analysis Of Wordle Games Based on Multiple Logistic Regression and Clustering
Authors: Liu Guangsheng , Cai Binjian , Liao Junlin
Published: September 2023

The development of social media has led to an increasing number of people participating in the online guessing game Wordle, which has become a popular phenomenon on Twitter. Understanding the difficulty of the Wordle game is important for both players and game designers. This article aims to gain an in-depth understanding of the game by analyzing its gameplay reports and word difficulty. Firstly, this article predicts the distribution of Wordle report results. Using a multivariate logistic regression model, the probability distribution prediction is converted into a classification problem, with word attributes and the average number of guesses per player as independent variables for prediction. At the same time, this article introduces random noise into the model prediction to address low probability issues. The model is evaluated using MAE and RMSE, and sensitivity analysis is conducted using k-fold cross-validation. In order to further evaluate the difficulty of words in the game, this article uses the entropy weight-TOPSIS method combined with the Bi-Kmeans classification model to classify word difficulty. The model results show that word difficulty can be divided into five categories. Finally, this article evaluates the performance of the model using Davies-Bouldin Index and the Silhouette Coefficient, and the results show that the model has strong reliability and persuasiveness.
Review on the Research and Application Progress of TRD Construction Method in Foundation Pit
Authors: Wang Yizhao , Zhang Siyuan , Li Zhili , Min Xing , Zhang Xuqun , Lan Zhi , Li Senyu
Published: September 2023

with the development of the times, the expansion of urban scale and the development and utilization of underground space, the building foundation pit is developing in the direction of "large and deep". The traditional deep foundation pit support construction technology can no longer meet people's needs for the construction of deep and large foundation pits, thus deriving a new construction technology TRD construction method, which has a wide range of application, guaranteed wall quality and depth, and high construction efficiency. This construction method has been born for more than 30 years and has been popularized and applied in China for more than 10 years. This paper will briefly introduce the trd method from the aspects of its development, characteristics and academic research process of related applications. It is not difficult to see from the relevant research that the trd method has broad application prospects in China.
Fatigue Crack Extension and Life Calculation Based on Finite Element Analysis
Authors: Zhang Yifan , Ma Yunlei , Liang Mingyu
Published: September 2023

With compact tension specimen static stress analysis and fatigue life of crack as the research object, through the three-dimensional modeling software to establish compact tension specimen, using the finite element analysis software to sample statics analysis, get the maximum deformation and maximum stress, and the compact tensile samples prefabricated crack, using the fatigue crack propagation analysis software, The cycle times and a-N curves were obtained.  This method can be used to calculate the fatigue crack propagation life and visualize the crack propagation process, which is convenient to analyze and master the fatigue mechanism.
Map Optimization of Path Planning in Q-Learning
Authors: Li Ye
Published: September 2023

Path planning is significant in the field of artificial intelligence and robotics. This paper proposes a unique map optimization of path planning relying on Q-learning to overcome the shortcomings of classic Q-learning, such as delayed convergence or low efficiency. First, improvements were made to the setup environment, turning a simple environment into a more complex one. Secondly, rewards were set to ensure that each step is optimal exploration. The optimal path is the globally optimal path by setting up, down, left, and right directions simultaneously. Finally, MATLAB simulation was used for verification. As compared to the original training environment, the improved map enhances learning efficiency in a more complicated environment, increases the algorithm's convergence rate, and enables the robot to swiftly discover the collection-free path and finish the job in a complex environment. The rationality of the improvement is verified, which provides important data and a theoretical basis for the subsequent research on Q-learning.
Analysis of Grasping Target by Simulated Six-Axis Robot
Authors: Jing Guanxiang
Published: September 2023

A six-axis robot is a type of robotic manipulator with six degrees of freedom (DOF) that enable it to move and rotate in six different directions. Because of its flexibility and high-precision operation, it is widely used in industrial production lines, semiconductor manufacturing, medical surgery and other fields. In the future, with the development of artificial intelligence, sensor technology and other fields, six-axis robots will achieve more intelligent and autonomous operation, and will also be more widely used in industry, medical treatment, service and other fields. In this paper, the important applications of six-axis robots in industry and other fields are introduced by introducing the relevant applications of artificial intelligence and robots. Then the DH representation method and inverse solution method are introduced, and a six-axis robot is modeled and the relevant data are calculated in MATLAB software using the DH representation method and inverse solution method. Finally, the trajectory of the robot gripper was simulated and the simulation results were obtained, which preliminarily verified the feasibility and reliability of the six-axis robot grasping objects.
Asteroid Mining Evaluation Model Based on AHP and TOPSIS
Authors: Feng Wenbin , Zhao Qi , Zheng Ruoshan , Zheng Ruoshan
Published: September 2023

It is assumed that future mining trips to asteroids will be possible and that humans will be able to bring valuable minerals back to Earth for investment at a relatively safe cost. Therefore, it is important to explore the impact of asteroid mining on global equity.First，we first used hierarchical analysis to determine the weights using five indicators: military, economic, scientific research, social, and environmental. Then the five superior indicators were subdi-vided into 20 inferior indicators, and the data from each national statistical office were used to score the strength of the eight countries using the TOPSIS method based on entropy weighting, while cluster analysis of the data was performed to verify that our model was better.
Entropy-TOPSIS Method to Study the Factors Affecting Light Pollution
Authors: Ding Qirui , Huang Yongshuai , Zhu Chenhao
Published: September 2023

The problem of light pollution, which arises from the excessive or poor use of artificial light sources, has become a global issue. Identifying and solving the light pollution problem will have a positive impact on human and ecological environment. In this paper, the entropy-TOPSIS method addresses the degree of influence of each factor on light pollution and finds appropriate improvement measures based on the characteristics of data that may affect light pollution factors. The entropy-weighting method is used to score different areas with different degrees of light pollution, and then the weights of each factor are obtained, and the TOPSIS method is used to score the degree of light pollution in each area based on the superiority and inferiority distances. Finally, the light pollution evaluation model is obtained.
Comparative Model Study of Global Temperature Forecasting Based on the ARIMA-OLS Model
Authors: Liu Kerui , Zheng Boyu , Ding Xinning
Published: September 2023

Global warming is the most important climate issue for mankind today. Predicting the direction of future global temperature change is particularly important to develop relevant response strategies. To reasonably predict the future pace of global warming, this paper firstly collects global monthly average temperature data from Berkeley Earth, covering major land areas around the world and monthly sea surface temperatures from 2012 to 2022, to ensure wide spatial coverage and high data integrity. Based on the data's cyclical and stable growth characteristics, a time series model and a simple regression model are established. Then, temperature forecasts for 2050 and 2100 are generated using the ARIMA model and simple regression model separately. Results reveal that both models predict months when the average temperature exceeds 20 degrees Celsius in 2050 and 2100. However, only the simple regression model predicts that the average annual temperature will surpass 20 degrees Celsius in 2100. Considering the trend of global warming, this paper supports the superior predictive capability of the simple regression model. The paper contributes to climate analysis, providing valuable insights for understanding future temperature trends and guiding further research in this field.
Analysis of Bubble Motion Characteristics in Oil Based on Level Set Method
Authors: Zeng Yanming , Ren Jixiang , Bao Yichen
Published: September 2023

At present, transformer oil is the primary insulation method for large power transformers, and the dynamic behavior of bubbles in transformer oil can impact the insulation performance of transformer oil. Therefore, based on the level set method in this paper, the motion characteristics of bubbles in two structures, a horizontal oil channel and a vertical oil channel, under various conditions of different bubble numbers, different flow velocities, and different bubble sizes are studied using finite element simulation. The simulation results show that the kinetic behavior of bubbles becomes more complicated as the radius increases, the number of bubbles increases, and the flow velocity increases. At the same time, the bubble expansion and deformation is a cyclic process due to the electric field force, laminar flow and surface tension in the bubble suspension process.
Preface: 2nd International Conference on Modern Medicine Technology and Clinical Science (MMTCS 2023)
Authors: Whitman Deirdre , Liu Huiyan
Published: September 2023

We are glad to introduce you that the 2023 2nd International Conference on Modern Medicine Technology and Clinical Science (MMTCS 2023) was successfully held in Tokyo, Japan from July 15-16, 2023. This conference brought together innovative academics and industrial experts in the fields of modern medicine technology, pharmaceutical engineering, and clinical science and application to a common forum.

The primary goal of the conference is to promote research and developmental activities, and another goal is to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working all around the world. During the conference, the conference model was divided into three sessions, including oral presentations, keynote speeches, and Q & A discussion. All the papers have been processed to meet the requirements of international publication standard. We selected a bunch of high-quality papers and compiled them into proceedings after rigorously reviewing.

We would like to express our sincere gratitude to the distinguished keynote speakers, as well as all the participants. We also want to thank the publisher for publishing the proceedings. May the readers could enjoy and gain some valuable knowledge from the MMTCS 2023 proceedings. We are expecting more and more experts and scholars from all over the world to join this international event next year.

The Scientific Committee of MMTCS 2023

Tokyo, Japan
The Effect of Engineering Methods on the Efficacy of Therapeutic Exosomes
Authors: Zhang Chentao
Published: September 2023

Exosomes have been brought to attention in recent years with the rapid development of cell therapy and biotechnology. Exosomes are small extracellular vesicles that facilitate intercellular communication and play a crucial role in various physiological and pathological processes. They have been proven to be less harmful in comparison to other vector counterparts. With engineering methods, the efficacy of exosome therapy can be further amplified. This literature review aims to overlook the current state of knowledge on engineering methods used to enhance the efficacy of therapeutic exosomes. By incorporating knowledge from previous studies, this article attempts to discover a direct influence of engineering methods on the efficacy of exosome therapy in main three aspects: enhanced ligand-gated targeting, larger production yield, and a larger degree of freedom to deliver different mediums. The following literature will mainly focus on engineering advantages for treating different types of cancer.
Construction of the biocompatible and pH-sensitive prodrug nanoparticles via the self-assembly for improving tumor therapy
Authors: Liu Bingjun
Published: September 2023

Endosomal pH-responsive micellar nanoparticles were prepared by self-assembly of a macromolecular poly(ethylene glycol)-Schiff-Doxorubicin (PEG-Schiff-DOX) prodrug.. These nanoparticles exhibited excellent storage stability for over 1 week under normal conditions, but disassembled quickly in response to faintly acidic environment. According to the EPR effect, the surface pore diameter of tumor blood vessels can reach hundreds of nanometers, while the surface pore diameter of ordinary blood vessels does not exceed 20 nanometers. Therefore, the chemical assembly of the drug is designed to have a diameter of 20-200 nanometers, thereby greatly improving the selectivity of the drug for tumor cells. Additionally, benefitting from the difference in drug release mechanism and rate between encapsulated DOX and conjugated DOX, a programmed drug release behavior was observed, which may result in higher intracellular drug concentration and longer action time. CCK-8 assays showed that the nanoparticles demonstrated superior antitumor activity than free PTX against both HeLa cells. These nanomedicines, which utilize prodrugs, exhibit immense promise in the advancement of translational DOX formulations for cancer treatment.
Tetrodotoxin Toxicology and Its Therapeutic Uses
Authors: Liu Yuyang , Nie Chuanyao , Xia Cuiya
Published: September 2023

Tetrodotoxin (TTX) is a potent neurotoxin found in various marine as well as terrestrial organisms. Despite lethal effects, recent research has shown that TTX may have therapeutic potential for certain medical conditions. The goal of this paper is to provide a general understanding of TTX toxicity, including its structure and mechanism of action and clinical manifestations of poisoning. TTX blocks the nerve impulse transmission and lead to severe possible lethal effect, including paralysis, respiratory failure and cardiac arrest. Additionally, some potential therapeutic uses of TTX will be discussed, such as pain management and treatment for pains including neuropatic pain, viseral pain and several other types. TTX nevertheless remains a extremely dangerous substance despite these potential therapeutic uses, thus precautions must be considered when utilizing and administering it. The challenges associated with developing safe and effective TTX-based therapies will also be highlighted. Overall, this review provides insight into the complex nature of TTX toxicity while exploring its promising applications in medicine.
Graphene-Based Devices: Exploring Advantages, Challenges, and Multidisciplinary Applications
Authors: Chen Jimai
Published: September 2023

This study investigates the properties and possible uses of graphene, a two-dimensional material, in a variety of areas, such as electronics, optoelectronics, energy storage, and biomedicine. The study aims to explore the advantages of using graphene-based devices, identify potential applications in different fields, and assess the feasibility of incorporating graphene into these applications. The paper overviews the current state-of-the-art in developing graphene-based devices and describes their unique properties. Subsequently, the study delves into the potential applications of graphene in electronics, optoelectronics, energy storage, and biomedicine, each represented by a dedicated sub-section. The applications explored include graphene transistors, sensors, interconnects, photodetectors, solar cells, light-emitting devices, supercapacitors, batteries, biosensors, drug delivery systems, and tissue engineering. The paper concludes by summarizing the primary findings and offering a perspective on future research directions. The study highlights the potential of graphene-based devices in various domains and serves as a foundation for further investigation and development. The paper contributes to the growing body of knowledge on graphene and its applications, providing insights into the possibilities and challenges of incorporating graphene into different fields.
Causes and Development of Cancer and the Effect of Age on Cancer
Authors: Wang Che
Published: September 2023

Nowadays, the disease of cancer has received more and more attention and there are medicine and living strategies to improve the living state of people who get cancer and to prevent cancer from occurring. However, some publication on how to prevent cancer and what causes the cancer are not very thorough and clear. As a result, this passage will explain these issues clearly and provide some useful strategies that can help to prevent the cancer. To explain, smoking, problems associated with metabolism and inappropriate diets can lead to cancer; depression, decrease appetite, fatigue, insomnia and pain can be symptoms of cancer; physiological situation and appetite can be affected by the aging effect; epigenetic reprogramming and inflammation are the factors of why aging can cause cancer; people can have healthy diet like taking in healthy food such as mushrooms, honey, yogurt, bananas, tea, and get into good living habits like doing physical exercises or having good sleeps, besides, they should reduce the elements which can cause cancer like arsenic in the soil in their living places Finally, it is possible that there will be some more useful medicine or new techniques that can help people better prevent cancer from happening and to better improve the living situation of people who get cancer.
Medical Image Segmentation Research Status and Development Trends
Authors: Li Nan
Published: September 2023

As one of the important steps in medical image processing, medical image segmentation plays a pivotal role in clinical surgery and is widely used in application scenarios such as preoperative diagnosis, intraoperative navigation, and postoperative evaluation. In this paper, medical image segmentation technology is studied, and a variety of medical image segmentation methods are categorized and compared in an attempt to explore the development law of medical image segmentation technology. Firstly, the medical image segmentation technology is classified and studied according to its different methods, and this paper mainly researches and organizes the deep learning method for medical image segmentation; secondly, the principle, advantages and disadvantages, and applicable scenarios of each model are analyzed; and lastly, the latest progress of the medical image segmentation technology is objectively described. inherent deficiencies and solutions of the existing techniques, and provides a direction for continued improvement in the future. As one of the important steps in medical image processing, medical image segmentation plays a pivotal role in clinical surgery and is widely used in application scenarios such as preoperative diagnosis, intraoperative navigation, and postoperative evaluation. In this paper, we explore the critical role of medical image segmentation in medical image processing, particularly in clinical surgery and its various applications such as preoperative diagnosis, intraoperative navigation, and postoperative evaluation. Our study focuses on categorizing and comparing different medical image segmentation methods, with a special emphasis on deep learning techniques. We delve into the principles, advantages, disadvantages, and suitable scenarios for each model. Additionally, we objectively present the latest progress in medical image segmentation technology, addressing existing deficiencies and proposing potential solutions. This research provides valuable insights to foster continuous advancements in the field.
Advances in Research on the Relationship between Glutamine Metabolism and Breast Cancer
Authors: Wang Yanqiu , Zhang Haotian , Chu Yi
Published: September 2023

Breast cancer is the highest incidence of cancer in women. In recent years, the incidence of breast cancer has been climbing, and the age is becoming younger and younger. Recent studies have shown that glutamine metabolism can promote the occurrence and progression of breast cancer, and is related to malignant proliferation, metastasis and drug resistance of breast cancer. Targeting glutamine metabolism is an important strategy for the treatment of breast cancer. This article reviews the mechanism of glutamine metabolism in breast cancer cells and its research progress and therapeutic significance in different molecular subtypes of breast cancer.
Graph Theory in DNA Sequencing: Unveiling Genetic Patterns
Authors: Ashton Banda
Published: September 2023

Graph theory, a branch of mathematics that studies the properties and relationships of graphs, has emerged as a powerful tool in addressing the complexities of DNA sequencing. This paper highlights the application of graph theory in DNA sequencing and its implications in various aspects of genomics research. One fundamental concept in graph theory applied to DNA sequencing is the construction of the de Bruijn graph. This graph represents overlapping k-mers, subsequences of length k, as nodes, with edges connecting adjacent k-mers. By constructing and analyzing the de Bruijn graph, researchers can infer the underlying DNA sequence, detect errors, resolve repetitive regions, and identify structural variations in the genome. Graph algorithms such as Overlap path, Eulerian path and Hamiltonian path have been adapted to reconstruct complete DNA sequences from fragmented reads obtained through sequencing. These algorithms leverage the connectivity information present in the de Bruijn graph to traverse and assemble the reads, enabling the reconstruction of long DNA sequences accurately. the application of graph theory in DNA sequencing has revolutionized the field of genomics by providing powerful computational tools for DNA assembly, sequence analysis, and functional annotation. By leveraging graph theory concepts and algorithms, researchers can unravel the intricate information embedded within DNA sequences, leading to deeper insights into the genetic basis of life and its applications in various fields, including medicine, agriculture, and evolutionary biology. Future developments in graph-based algorithms and computational techniques hold promise for further enhancing our ability to unlock the secrets encoded within the vast realm of DNA sequences.
Research on the Effect of Traction Combined with Acupuncture and Massage Function Exercise on Patients with Lumbar Disc Herniation
Authors: Liang Bingshuang , Wu Ting , Yang Yucheng
Published: September 2023

To study the clinical effect of traction combined with acupuncture and massage function exercise in the Treatment of lumbar disc herniation. Methods A total of 180 patients with lumbar intervertebral disc herniation were selected and randomly divided into traction group, acupuncture group, combined group, and control group, with 60 cases in each group. The traction group was treated with traction, while the acupuncture group and the combined group were treated with traction combined with acupuncture and massage. Results After Treatment, the total effective rate was 76.56% in the traction group, 62.3% in the control group, and 98.44% in the acupuncture and combined groups. Comparing the curative effects of the three groups, the traction group was better than the control group (P<0.05), and the traction combined with acupuncture and massage was better than the traction group (P<0.05). It shows that traction therapy is better than acupuncture and massage, and the efficacy rate of traction therapy combined with acupuncture and massage is better than that of traction therapy. Conclusion Traction combined with acupuncture and massage function exercise has a better curative effect on patients with lumbar intervertebral disc herniation, which is worthy of popularization and application, is safe, and has high clinical value.
Research Progress on the Relationship between Gastric Microorganisms and the Occurrence and Development of Gastric Cancer
Authors: Song Dan , Wang Peilong , Zhao Wanbin
Published: September 2023

The changes of composition and function of gastric microflora are closely related to the occurrence and development of gastric cancer (Gastriccancer, GC). Gastric microflora has great potential as a biomarker for diagnosis and risk assessment of gastric cancer. There is a complex flora structure in the stomach. The changes of gastric microenvironment caused by Helicobacter pylori (H. pylori HP) may change the flora structure and mainly participate in the early process of gastric carcinogenesis. Gastric microflora other than Helicobacter pylori may play a role in the last steps of gastric carcinogenesis. Exploring the mechanism of gastric microorganisms in the occurrence and development of gastric cancer is helpful to provide a basis for early diagnosis and treatment of gastric cancer. This article mainly reviews the role of Helicobacter pylori and other microorganisms in the occurrence and development of gastric cancer.
Breast Cancer Prediction based on Support Vector Machine
Authors: Liu Tianci , Li Xiangjun
Published: September 2023

Breast cancer is the most common malignant tumor among women in the world, and its mortality rate ranks second. In this paper, the breath cancer Wisconsin (diagnostic) data set is used for prediction. First, exploratory data analysis was carried out, and 10 indicators related to breast cancer were selected as independent variables. Then, support vector machine (SVM) and logistic regression model were used as classifiers, and 75% of data sets were divided into training sets to build models. Finally, 25% of test sets were used as input models for prediction, and accuracy and recall were used as evaluation indicators to compare and analyze the advantages and disadvantages of the two algorithms. The results show that the accuracy of SVM is 16.2% higher than that of logistic regression, and the recall rate is 9.2% lower. The prediction application of SVM algorithm shows that SVM algorithm has low computational complexity and strong generalization ability. Therefore, support vector machine can be used to improve the diagnostic accuracy in the diagnosis of breast tumors.
Progress in the Study of Glycosylated Haemoglobin Variability Index in Relation to Chronic Complications of Diabetes Mellitus
Authors: Chen Ruihong , Luo Liangping
Published: September 2023

Diabetes mellitus (DM) is a common endocrine disease that can cause damage to tissues and organs throughout the body. Glycosylated haemoglobin (HbA1c) is considered to be the gold standard for assessing glycaemic control and treatment outcomes in patients with diabetes, but there is individual variability that affects the accurate interpretation of blood glucose. The glycosylated haemoglobin variability index (HGI) is a measure of individual variability in HbA1c and can be used in the management and treatment of patients with DM. In this paper, the relationship between HGI and chronic complications of DM is reviewed and discussed, with the aim of providing a more individualized and accurate reference for clinical management of blood glucose and risk assessment of chronic complications in DM patients, reducing and delaying the occurrence of chronic complications of diabetes and improving the quality of life of DM patients.
Optimization Operation Status and Prospect of Multi-microgrid System
Authors: Shu Qi , Wang Zexuan , Xu Pin
Published: September 2023

The uncertainty and intermittency of renewable resources, the time-varying power generation and radiation of generator sets, and the energy coupling between generator sets in the process of energy trading all bring severe challenges to the stable operation and optimal dispatch of the power system. To this end, the energy management system in the current multi-microgrid system is analyzed. The topology, time scale and dispatch optimization structure in microgrid are discussed. The results show that the microgrid structure is conducive to the construction of new power system and plays an important role in promoting the transformation and reform of power system in the future.