bluuebunny/crossref_metadata_2025 huggingface dataset:
Peaceful Coexistence Through the Concepts of Brahmavihārās of Buddhism and Maqāṣid al-Sharīʿa of Islam: A Content Analysis
Authors: Ashath Mohamed
Published: October 2022

To understand every religion, it is vital to study the main sources, the specific religious scriptures of a particular religion. In order to draw a conclusion about the core message of religion, it is not scientific to observe only the practices of the adherents of a certain religion. Although Buddhism and Islam have been considered as religions of peace, the meeting of Buddhists and Muslims is most often imagined as one of violent confrontation in the modern world. There should be an understanding between Buddhism and Islam to ensure peaceful coexistence among the adherents. Based on the arguments,this study aims to analyze peaceful coexistence through two different concepts, Brahmavihārās from Buddhism and Maqāṣidh al-Sharīʿa from Islam. Primarily it seeks to analyze these two concepts within their respective religions for a better comparison. It uses a library-based qualitative method. For this purpose, the research adopts the content analysis method, which focuses on the materials from journals, books, written reports, and other materials. The study highlights that even though Buddhism and Islam have different doctrinal foundations, the basic teachings promote peaceful coexistence from different points of view. This research concludes that both religions share similar concepts of peaceful coexistence which denote and declare human dignity as a right that should be paid attention. Both religions prioritize love and justice as the main standard in discussing peaceful coexistence. Hopefully, this conceptual study will be able to show that these two ideas are very significant and valuable when dealing with religious conflicts, to make a better inter-religious understanding among Buddhists and Muslims and to succeed in a process of reconciliation and for peaceful coexistence among diverse religious people.
Effect of Parboiling on the Physicochemical and Phytochemicals Characteristics of Traditional Rice Cultivars
Authors: Sri M.J. Anitha , Kanchana S. , Geetha P.S. , Mini M.L. , Vanniyarajan C. , Ejilane J. , Pasupathi E.
Published: October 2022

Background: The indigenous rice varieties of India are cultivated and utilized by tribal peoples as well as people in the distant regions with traditional culture. The main aim of the research work was to explore the inherit beneficial characteristics of traditional rice cultivars over hybrid varieties. Methods: The research work was aimed to investiagate the physicochemical and phytochemicals characteristics in traditional red rice cultivars (Mapillai Samba and Karungkuruvai) and traditional white rice cultivars (IR 20 and Improved White Ponni). The different treatments used in the study were raw rice (unpolished, polished) and parboiled rice (unpolished, polished). The interaction between physicochemical characteristics and phytochemicals were evaluated using Pearson correlation and Principal component analysis. Result: The physicochemical characteristics were analyzed for all the rice cultivars. It was observed that parboiled-unpolished mapillai samba showed highest length, breadth, 1000 grain weight. The raw rice cultivars showed highest phytochemicals than parboiled rice. The total phenolic, total flavonoids and total anthocyanin contents were highest for the mapillai samba (raw rice-unpolished). Among different traditional rice cultivars, mapillai samba showed significantly higher antioxidant levels. The results of the study suggested that these traditional rice cultivars can be incorporated in value added products.
A Clinical Study on the Surgical Management of Third Eyelid Gland Prolapse in Dogs
Authors: Sowmya D. Sri , Reddy K. Jagan Mohan , Latha C.
Published: October 2022

Background: The current study was undertaken to evaluate the clinical efficacy of two different surgical methods for management of third eyelid gland prolapse in dogs. Methods: The study was conducted on 14 eyes of 11 dogs presented with third eyelid gland prolapse for surgical treatment. Two groups dogs were subjected to clinical and ophthalmic examination based on the surgical technique used i.e., Group I (n=8) in which modified Morgan’s pocket technique, Group II (n=6) in which modified orbital rim anchorage technique was used. Among the breeds brachycephalic dogs (54.54%, n=6) followed by mesocephalic dogs (45.45%, n=5). The modified Morgan’s pocket technique was adopted in 8 eyes of 7 dogs (1 bilateral, 6 unilateral) and the modified orbital rim anchorage technique was performed in 6 eyes of 4 dogs (2 bilateral, 2 unilateral). In Group I, the mean pre-operative Schirmer tear test value was 16.87±0.72 mm/min and in Group II, it was 17.33±0.67 mm/min, both values increased on 30th Post-operative day. Statistical analysis revealed that there was no significant difference between the two groups (p greater than 0.05), but there were significant differences within each group (p less than 0.05). The fluorescein dye test was repeated on 1st,7th,14th, 30th days post-operatively and found positive in the left eye of one dog with the reduced bilateral cherry eye on 7th post-operative day in group I. Third eyelid mobility was normal post-operatively in all the cases of group I. Whereas in group II, it is restricted in all the cases. Three cases regained normal contour by the 10th post-operative day whereas 5 cases by the 14th postoperative day in group I. In group II, 3 cases regained normal contour by 12th post-operative day and 3 cases regained by 14th post-operative day. One case in the group I tested positive for superficial corneal ulcer on the 7th post-operative day. One dog in group I had a recurrence after 45 days of repositioning. One dog in group II with reduced bilateral cherry eye had a recurrence in the left eye 30 days after surgery. Result: Present study, Modified Morgan’s pocket technique was considered superior over the modified orbital rim anchorage technique in view of technical feasibility and unrestricted third eyelid mobility.
Thoughts of Bangabandhu Sheikh Mujibur Rahman on agricultural and industrial development in Bangladesh: An analysis
Authors: Billah Arif
Published: October 2022

Bangabandhu Sheikh Mujibur Rahman is one of the most undeniable and charismatic leaders in the world. He won the trust, support and hope of the general public as a result of his inherent and exceptional traits (East Bengalis). The purpose of this study is to examine the important roles he has played in boosting Bangladesh's economy. Secondary data was acquired from a range of sources, including journals, websites, articles and books, as well as descriptive and preferred qualitative approaches, and national and international media. Government documents, research papers and publications from international organisations, research institutes and individual academics were examined. Bangladesh has become a global role model for sustainable development in addition to achieving food security, thanks to its energetic efforts and future recommendations (1972–1975). Bangladesh is progressing quickly because of its ideologies and ideals. Bangladesh is on track to becoming a developed country by 2041, thanks to its ideologies and ideals.
 
Keywords: Agriculture, Bangabandhu, Bangladesh, development, economic;
Percepciones de los estudiantes de licenciatura sobre las pruebas estandarizadas de inglés
Authors: Vez López Enrique , Molina Muñoz Karla Elizabeth , Sánchez Hernández Diana Iveth
Published: October 2022

Este reporte de investigación examina las percepciones de un grupo de estudiantes de inglés como lengua extranjera con respecto a los exámenesestandarizados aplicados en una facultad de lenguas en el estado de Veracruz, México. En este programa académico, todos los estudiantes toman los mismos exámenes, cuyo fin es evaluar su nivel de competencia en inglés. Para este estudio se utilizó un cuestionario con preguntas abiertas y cerradas con el objetivo de examinar los puntos de vista de los participantes en lo que se refiere al diseño de los exámenes, su validez, e imparcialidad. En el presente reporte, se utilizan tanto datos numéricos como las opiniones de los estudiantes para apoyar la presentación de resultados. Al analizar las respuestas al cuestionario fue posible identificar si los participantes consideraban que este tipo de exámenes son justos, confiables, y válidos para evaluar su competencia en inglés. Adicionalmente, esta investigación ayudó a identificar debilidades y fortalezas de los exámenes estandarizados en este contexto
¿Píri mu rimúli?: la narración de los sueños en el rarámuri de Norogachi
Authors:   Universidad Nacional Autónoma de México, Instituto de Investigaciones Antropológicas - Instituto de Investigaciones Filológicas, Villalpando Quiñonez Jesús , Espino Moreno Regina ,   Hablante de rarámuri, Holguín Javier Jaime ,   Hablante de rarámuri
Published: October 2022

the topic of dreams has been extensively studied by cultural and linguistic anthropologists (graham 2001; Mannheim 1991), but what we know about this social practice from the perspective of lin-guistic documentation is minimal. this paper presents three oral texts where speakers of norogachi Rarámuri narrate their dreams. the goals of this paper are twofold, on the one hand, it documents a practice that shows an important social meaning for the Rarámuri people, and from then, the second goal focuses on presenting the linguistic characteristics of such social practice. among the formal characteristics found in this type of narrative are repetitions at the lexical and phrasal level, the use of epistemic adverbs such as niráa ‘(a)like’, the use of specialized forms for narrating dreams which have not been previously described with these functions for Rarámuri, and the use of nominalized forms, which suggest that events are presented as states in dreaming narration. this paper documents a previously unattended type of narration among linguistic studies, but one that shows particular characteristics of importance for both linguistic and ethnographic description.
Professionals as Targets in the Culture Wars: A European Perspective
Authors: Morgado Pedro
Published: October 2022

N/a.
Changes in physical activity and energy intake according to abdominal obesity in Korean adult men before and after COVID-19: Data from 2019 and 2020 Korea National Health and Nutrition Examination Survey (KNHANES)
Authors: Park Mi-Young , Chung Nana
Published: October 2022

[Purpose] This study aimed to investigate changes in physical activity and energy intake according to abdominal obesity in Korean adult men before and after COVID-19.[Methods] Using data from the 2019 and 2020 KNHANES, the physical activity level measured by the Global Physical Activity Questionnaire (GPAQ) the physical activity level by GPAQ, number of days of walking and strength training, aerobic exercise, and total energy, protein, fat, carbohydrate, dietary fiber, and sugar intake for a total of 2,799 participants were analyzed.[Results] There were no changes in energy intake during the pandemic. The number of days of weekly walking was higher (2019, p = 0.006; 2020, p = 0.012) and strength training was significantly higher (2019, p < 0.0001; 2020 p < 0.0001) in the non-abdominal obesity group than in the abdominal obesity group before and after COVID-19. Strength training at least once a week suppressed abdominal obesity (0.628 times in 2019, p < 0.0001; 0.605 times in 2020, p < 0.0001). In addition, even when the total energy intake and age were adjusted for, strength training influenced the suppression of abdominal obesity (0.634 times in 2019, p < 0.0001; 0.614 times in 2020, p < 0.0001).[Conclusion] Even with the change in the physical activity level, such as walking and aerobic exercise, due to the influence of social distancing measures, strength training influenced the suppression of abdominal obesity, regardless of the COVID-19 pandemic.
Effects of combined hip exercise and passive stretching on muscle stiffness, pain perception and painrelated disability, and physical function in older adults with low back pain
Authors: Kim Ji-Hwan , Park Hun-Young
Published: October 2022

[Purpose] This study aimed to examine the effects of combined hip exercise and passive stretching as a novel treatment method for low back pain (LBP) in older adults.[Methods] Altogether, 20 Koreans with LBP aged 60–79 years (67.3 ± 5.92 years) were randomly assigned to undertake combined exercise (CE; n = 10) or lumbar stabilization exercise (LSE; n = 10). All participants performed their respective exercise program for 25–30 min with an OMNI scale of 6–8 for 8 weeks, three times a week. Body composition, muscle stiffness, pain-visual analog scale (P-VAS), Oswestry disability index, and physical function were evaluated before and after the exercise intervention.[Results] The CE group demonstrated greater improvements in lean body mass (η2 = 0.402, p = 0.003) and percent body fat (η2 = 0.222, p = 0.036) than the LSE group. Both groups demonstrated significant improvements in muscle stiffness, P-VAS scores, and Oswestry disability index scores, although no significant differences were observed between the interventions. All physical function parameters demonstrated a significant improvement in both groups, and the CE group demonstrated greater improvement in the YMCA sit-and-reach (η2 = 0.338, p = 0.007) and straight leg raise tests (η2 = 0.283, p = 0.016) than the LSE group.[Conclusion] CE is comparable to LSE as an effective and successful exercise intervention that reduces muscle stiffness and P-VAS scores. Moreover, CE is more effective than LSE in enhancing the physical function of older adults with LBP.
Comparison between predicted and measured resting energy expenditures in Korean male collegiate soccer players
Authors: Lee Sihyung , Moto Kuniko , Oh Taewoong , Taguchi Motoko
Published: October 2022

[Purpose] This study aimed to evaluate the differences between predicted resting energy expenditure (REE), using fat-free mass (FFM)-based prediction equations, and measured REE in Korean male collegiate soccer players.[Methods] Fifteen male collegiate soccer players (18-21 years) participated in this study. The REE measurements were conducted using the Douglas bag method. Body composition was measured by dual-energy X-ray absorptiometry (DXA). The differences between the measured REE and predicted REE, using the five FFM-based REE equations, were analyzed using the t-test, calculation of errors, regression analysis, and the Bland-Altman method.[Results] The Cunningham (1980) and ten Haaf and Weijs (2014) equations showed significantly overestimated REE (1,808 ± 99 kcal/d, p <0.01; 1,838 ± 103 kcal/d, p <0.01; respectively), but the Owen (1988), Taguchi (2011), and Kim (2015) equations’ estimations were not significantly different from the measured REE (1,589 ± 106 kcal/d, 1,640 ± 124 kcal/d, and 1,622 ± 68 kcal/d, respectively). The Taguchi equation gave the best prediction of REE with the lowest constant error (-6 ± 125) and effect size (-0.05), and a non-significant proportional bias (p = 0.95).[Conclusion] The Taguchi equation is recommended for predicting REE in Korean collegiate soccer players. The selection process of a REE-prediction equation must take into consideration the target population’s characteristics. Future studies are recommended to evaluate the validity of the different FFM-based REE-prediction equations in various Korean athletes.
Besin Alerjisi Tanılı Hastalarda Tolerans Gelişimi ve Toleransa Etki Eden Faktörler
Authors: ERSÖZLÜ Yasemin , ANIL Hulya , HARMANCİ Koray
Published: October 2022

Besin alerjisinin prevelansı bilinmemekle birlikte son yıllarda giderek arttığı tahmin edilmektedir. Genel olarak besin alerjileri pediatrik yaş grubunda erişkine oranla daha sık görülür. Çalışmamızda; polikliniğimizde gıda alerjisi tanısı olan hastalarımızın, doğal seyri, tolerans gelişimi ve toleransa etki eden faktörleri belirlemeyi hedefledik. Ocak 2013-Ocak 2016 yılı arasında polikliniğimizde Besin Alerjisi tanısı alan hastaların dosyaları retrospektif olarak incelendi. Hastaların cinsiyetleri, ilk semptom yaşı, anne sütü alma süresi, ailede atopi öyküsü, çoklu besin alerjisi, ek alerjik hastalık varlığı ve klinik bulguları değerlendirildi. Hastaların prik test sonuçları, total IgE, spesifik IgE, düzeyleri ve tolerans geliştirme durumları değerlendirildi. 319 hastanın 184’ü erkek (%57.7) idi. Hastaların 127’sinde (%39.8) ailede atopi öyküsü ve 71’inde (%22.3) çoklu besin alerjisi mevcuttu. Hastalarda görülen en sık semptom, %65.8 gastrointestinal sistem, %21 cilt bulguları, %6.3 solunum bulgularıydı. Hastaların semptom yaşı 5.8 ± 9,7 ay; tanı yaşı 6.6 ± 9.08 aydı. Hastaların yıllara göre tolerans geliştirme oranları; Birinci yıl 287 (%87,1) ikinci yıl 19’unda (%5,9) üçüncü yıl 9’unda (% 2,8) olarak saptandı. En sık alerjen gıda inek sütü (%71,3), yumurta (%17,6), fıstık (2,8), fındık (%2,04) olmakla beraber diğer gıdalar çilek, kakao, şeftali, buğday, soya, balık olarak saptandı. Çalışmamızda ilk yılda annenin sigara kullanımı ile besin alerjilerinde tolerans gelişimi arasında anlamlı fark saptanmıştır. Non Ig E aracılı besin alerjisi olanlar ve tek besine karşı alerjen olan hastalarda ilk yılda tolerans gelişimi anlamlı oranda faza saptanmıştır.
Hicri V. Asır Delâilü’n-Nübüvve Geleneği: Kadı Abdülcabbar ve Beyhâkî Örneği
Authors: AKBAŞ Hamdi
Published: October 2022

İslam toplumuna dâhil olan farklı dinî ve felsefî akımların Hz. Peygamberin nübüvvetine yaptıkları itirazları bertaraf edebilmek için Müslüman âlimlerce geliştirilen savunmacı refleks, tarihi süreçte delâilü’n-nübüvve isimli geleneğin oluşmasına zemin hazırlamıştır. İlkin Muʽtezilî âlimlerin çabalarıyla vücud bulmaya başlayan bu gelenek, daha sonra selefi düşünürler ile hadis âlimlerinin çalışmalarıyla daha da genişleyerek varlığını devam ettirmiştir. Bu gelişmeler nübüvvetin ispatında farklı metodların zuhur etmesini de doğal hale getirmiştir. Nitekim Mu’tezile’nin geliştirdiği akıl ve nakil merkezli tavrın yanı sıra sadece nakli merkeze alan bir rivayetçi yaklaşımın da ortaya çıktığı görülmektedir. Bu bağlamda Mu’tezilî kimliğiyle bilinen Kadı Abdülcabar’ın “Tesbitü Delâilü’n-Nübüvve” isimli eseri ile muhaddis kimliğiyle ön plana çıkmış Beyhâkî’nin “Delâilü’n-Nübüvve” isimli eseri, hicri beşinci asırda Muhammed'in nübüvvetini ispat etmek üzere iki farklı metod kullanılarak telif edilen eserlerdendir. Biz bu çalışmamızda hicri V. asırda metodik farklılıkları bulunan iki delail müellifi ile eserini tanıtmayı ve mukayese etmeyi planlamaktayız. Ayrıca müelliflerin hayatları hakkında bilgiler vermek suretiyle de bu iki müellifin yaşadığı süreç ve fikri ortam üzerinden metod farklılıklarının daha anlaşılır hale geleceğini de düşünmekteyiz.
The effects of foreign direct investment and trade openness on economic growth amid crises in Asian economies
Authors: Hossain Rabiul
Published: October 2022

Purpose ― The main objective is to examine the effects of foreign direct investment and trade openness on economic growth (SDG-8.1) about economic growth amid crises in 30 Asian economies.
Design/methodology/approach ― The effects of FDI and trade openness on economic growth in the Asian region are examined using the fixed-effects model, panel corrected standard errors (PCSE), and generalized method of moments (GMM) estimations. The study also measures the long-run effects of the estimates and the granger causality tests.
Findings ― The findings revealed that both FDI and trade openness contribute to boosting economic growth in Asian economies, and the effect is also persistent in the long run. We also find that the Asian and global financial collapse shocks in 1997-1998 and 2008-2009, respectively, adversely affected the region's economic growth. Additionally, the economic growths of some Asian countries are below the targeted level set in SDG-8.1. 
Practical implications ― The Asian countries should adopt appropriate policy measures for encouraging the inflow of FDI and cross-border trade of goods and services as it is evident that the inflow of FDI and open trade will improve local human capital and technological capabilities of the industries, which will ultimately help to enhance stable economic growth.
Originality/value ― This study is unique in accompanying the Asian financial crisis and world recession in studying the effects of FDI and trade openness on SDG-8.1 in Asian economies.
Lipofuscin as the Main Driving Force of Current Age-Related Disease: Justification and Strategies for Removal
Authors: Renteln Michael
Published: October 2022

Lipofuscin is indigestible garbage that accumulates in the autophagic vesicles and cytosol of post-mitotic cells with age. Drs. Brunk and Terman postulated that lipofuscin accumulation is the main or at least a major driving factor in aging. They even posited that the evolution of memory is the reason why we get lipofuscin at all, as stable synaptic connections must be maintained over time, meaning that the somas of neurons must also remain in the same locale. In other words, they cannot dilute out their garbage over time through cell division. Mechanistically, their position certainly makes sense given that rendering a large percentage of a post-mitotic cell’s lysosomes useless must almost certainly negatively affect that cell and the surrounding microenvironment. Here, I explore the possibility that the accumulation of lipofuscin to some extent underlies all other categories of age-related damage as defined by Dr. Aubrey de Grey. I do not think that lipofuscin removal will reverse/prevent all forms of aging, just the major component facing us currently. In this piece, I will review what is known about lipofuscin accumulation from evolutionary and mechanistic standpoints and discuss ways of removing it from non-dividing (or slowly-dividing) cells.
The Wave Reduction Efficiency How Relates with the Crest Widths, Working States of Pile-rock Breakwater in Coastal Mekong Delta
Authors: Nguyen Nguyet-Minh , Van Duong Do , Le Duy Tu , Pham Nhat Truong , Dang Duc Thanh , Tanim Ahad Hasan , Wright David , Thanh Phong Nguyen , Anh Duong Tran
Published: October 2022

The coastline in Ca Mau and Kien Giang provinces on Mekong Delta has been severely eroded in recent years. The Pile-Rock Breakwater (PRBW) was selected as predominant structure to construct widely more than 30 km on the west coast of Ca Mau. This structure shows the effectiveness of wave reduction, stimulating sediment accumulation and facilitating restoration of mangrove forest. However, this breakwater had been designed on the basis of best-engineering practice, lacking sufficient scientific background with regard to the structural design, capacity of wave reduction, working conditions. This study is to investigate the interaction of crest width, working states (submerged, transition and emerged) and the wave transmission coefficient, wave reflection coefficient and wave energy dissipation of PRBW by experiment in the laboratory and derive the empirical formulas for this construction under different sea states and crest widths. The results show a significant influence of width dimensions on the above coefficients. The findings revealed that the crest width of the breakwater is inversely proportional to the wave transmission coefficient (Kt) under emerged state. The crest width is also proportional to the wave reduction efficiency and wave energy dissipation in both working states (submerged and emerged states). The front wave disturbance coefficient is proportional to the reflected wave coefficient and the wave height in front of the structure can increase by 1.4 times in the emerged state. It is especially important to note when designing this structure to reduce the erosion in the structure toe due to the reflected waves. The empirical equations including linear and non-linear formulas have also developed and compared with previous studies for different breakwaters. This is necessary to be considered to calculate the structure and stability of breakwater. The results of this study serve as the basis for the design of pile-rock breakwater to reduce the waves under different natural conditions in the coastal area of the Mekong Delta.
The Flavonoid Rich Black Currant (Ribes nigrum) Gemmotherapy Extract Prevents Microglial Body Swelling in Hippocampus and Reduces Serum TNF-α Level: Pilot Study
Authors: Téglás Tímea , Mihok Emőke , Cziáky Zoltán , Oláh Neli-Kinga , Nyakas Csaba , Máthé Endre
Published: October 2022

The fruits and leaves of the black currant (BC, Ribes nigrum) contain phytochemicals with thera-peutic benefits. The current paper reports on a standardized BC gemmotherapy extract (BC-GTE) prepared from fresh buds, and details the extract specific flavonoid content, antioxidant, and an-ti-inflammatory properties, respectively. The main HPLC identified aglyka flavonoids were lute-olin, quercetin, apigenin and kaempferol, while all together, at about 133 phytonutrients could be detected in the reported BC-GTE, so that the BC specific presence of many compounds was re-ported for the first time. We also demonstrated that in adult male Wistar rats pretreated with BC-GTE, and assessed after the LPS injection, the body size modifications of the activated microglial cells in the hippocampal CA1 region were not apparent, and no elevated serum specific TNF-α levels were seen under such LPS induced inflammatory conditions. The specific flavonoid content, and the LPS induced in-flammatory model based experimental data are all suggesting that the assessed BC-GTE seems to feature anti-neuroinflammatory property, holding the promise of a novel GTE based comple-mentary therapeutic approach.
Water Balance Evaluation for Flood Risk Reduction in the Yala River Basin, Western Kenya
Authors:   School of Disaster Management and Humanitarian Assistance, Masinde Muliro University of Science and Technology, Kakamega, Kenya, Kiluva Mary , E.S Wanyonyi , J.W Wakhungu
Published: October 2022

The Yala River Basin (YRB) in Western region of Kenya has in the past experienced climate and weather extreme events that include floods. Floods have triggered loss of lives, destruction of property, outbreak of water borne diseases and siltation of arable land. This study utilized the Nedbør-Afstrømnings-Model (NAM) hydrologic model (available in the NAM Module of the MIKE 11 hydrodynamic model) on the Yala River Basin (YRB) to generate flood flows for water balance evaluation. The study utilized satellite imagery data for the period 1984-2010 sourced from the Regional Centre for Mapping of Resources for Development, rainfall (1980-2012) and river discharge (1947-2012) data sets from the Kenya Meteorological Department (KMD) and the Water Resources Management Authority (WARMA), respectively. Data quality control was statistically checked before sensitivity analysis, calibration, validation, and simulation of the flood flows. Daily water balance estimates for the Yala River Basin (YRB) over the period 1980-2010 were developed using the NAM hydrologic model. The results indicate that the mapped flood area extent varied by a value of 34.23 km2 over the period 1980-2010. The Yala River Basin (YRB) indicated an estimated inflow value of 4,814.72 MCM and outflow value of 4,578.23 MCM, with a coefficient of determination of 0.867. The difference between the inflow and outflow values was 236.49 MCM, that formed the flood flow or the water balance. This study concluded that the water balance value of 236.49 MCM was responsible for the floods recorded in the Yala River Basin (YRB) for the period 1980-2010, and it should be taken care of through flood risk reduction initiatives.
PROTOTIPE SMART REAL TIME ALARM BERBASIS ARDUINO MEGA 2560 DI RUANGAN ORGANISASI KEMAHASISWAAN
Authors: Eka Rahmah Pratiwi Adinda , Fahmy Resmont , Yusro Muhammad
Published: October 2022

The purpose of this thesis is to make a prototype realtime alarm in the student organization room as a reminder of the lecture schedule to be more efficient and for access in and out of the members' room as a safety. The method used in this research is the experimental method. This experimental research was conducted in system design, both in hardware design and software design of this device. This prototype diagram consists of an input block diagram that containing a fingerprint sensor and an RTC module, block diagram control set by Arduino Mega 2560, and output block diagrams containing LCD, solenoid, dfplayer, servo motor, relay and speaker. Test results that the author has done, this prototype has been running in accordance with the program created. The results obtained are fingerprint sensors can detect fingerprints of members when entering or exiting. When members enter or exit, the solenoid will open the door lock and the servo motor will open the door. Then the alarm will activate and make a sound from the speaker 10 minutes before the lecture schedule. This system will work repeatedly until the system is turned off.

Tujuan penelitian ini adalah membuat prototipe real time alarm di ruangan organisasi kemahasiswaan sebagai pengingat jadwal jam perkuliahan agar lebih efisien serta untuk akses masuk dan keluar ruangan anggota sebagai pengaman. Metode yang digunakan dalam penelitian ini adalah metode eksperimen (uji coba). Penelitian eksperimen ini dilakukan pada perancangan sistem, baik pada perancangan perangkat keras (hardware) maupun perancangan perangkat lunak (software) dari alat ini. Diagram prototipe ini terdiri dari blok diagram input yang berisi sensor fingerprint dan modul RTC, blok diagram kontrol yang diatur oleh Arduino Mega 2560, serta blok diagram output yang berisi LCD, solenoid, dfplayer, motor servo, relay dan speaker. Hasil pengujian yang telah penulis lakukan, prototipe ini telah berjalan sesuai dengan program yang di buat. Hasil yang didapat adalah fingerprint dapat mendeteksi sidik jari anggota pada saat masuk atau keluar. Pada saat anggota masuk atau keluar solenoid akan membuka kunci pintu lalu motor servo akan membuka pintu. Kemudian alarm akan aktif dan mengeluarkan suara dari speaker saat 10 menit sebelum jadwal perkuliahan  anggota.  Sistem ini akan bekerja terus berulang hingga sistem dimatikan.
KELAYAKAN MODUL PEMILIHAN BAHAN BUSANA PENGANTIN PADA MATA KULIAH BUSANA WANITA 3
Authors: Suci Amalia  , Suryawati Suryawati , Rawiyah Lubis Harsuyanti
Published: October 2022

Penelitian ini bertujuan untuk penilaian kelayakan bahan pembelajaran berbentuk modul dengan materi bahan busana pengantin dalam mata kuliah busana wanita 3. Metode yang digunakan dalam penelitian ini adalah metode Pre-Experimental dengan desain One-Shot Case Study. Teknik analisis data yang digunakan Kuantitatif Deskriptif. Menggunakan variabel tunggal yaitu variabel bahan ajar modul Busana Wanita 3 Materi Bahan Busana Pengantin. Penelitian ini menggunakan indikator penilaian bahan ajar dengan aspek materi, aspek penyajian, dan kebahasaan, dan berdasarkan 5 karakteristik modul yaitu pembelajaran diri (self-instruction), satu kesatuan (self-contained), berdiri sendiri (stand alone), menyesuaikan diri (adaptive), dan mudah digunakan (user friendly). Hasil penelitian menyatakan  bahwa modul pembelajaran Busana Wanita 3 Materi Bahan Busana Pengantin dengan memperoleh persentase rata-rata 82,5% sebagai bahan ajar modul. Penilaian berdasarkan nilai tertinggi aspek bahan ajar, pada aspek materi dengan persentase 80% karena aspek materi modul Busana Wanita 3 tersusun sistematis sesuai dengan acuan Rencana Pembelajaran Semester (RPS). Aspek media dengan penilaian tertinggi didapatkan pada aspek User Friendly dengan persentase 94% , karena aspek media disusun dengan bahasa yang komunikatif sehingga bagi pengguna mudah dipahami. Penilaian berdasarkan nilai terendah dalam aspek bahan ajar, pada aspek kebahasan dengan persentase 75%. Nilai terendah pada aspek media terdapat pada aspek satu kesatuan (Self Contained), persentase 75%.
Fetuin A: Is a New Biomarker for Growth?
Authors:   Department of Child Health and Diseases, Yozgat Bozok University Faculty of Medicine, Yozgat, Turkey, Domur Esra , Tubas Filiz ,   Department of Child Health and Diseases, Yozgat Bozok University Faculty of Medicine, Yozgat, Turkey, Turksoy Vugar Ali ,   Department of Public Health, Faculty of Medicine, Yozgat Bozok University, Yozgat, Turkey, Tutkun Lütfiye ,   Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara, Turkey, Ercan Mujgan ,   Department of Biochemistry, Faculty of Medicine, Harran University, Sanliurfa, Turkey, Arısoy Fatma İnci ,   Department of Child Health and Diseases, Yozgat Bozok University Faculty of Medicine, Yozgat, Turkey
Published: October 2022

Vitamin D deficiency is common in the World and Turkey due to changing lifestyles. The association with autoimmune diseases such as obesity, metabolic syndrome, diabetes, cardiovascular diseases and important diseases such as cancer has made it important to prevent vitamin D deficiency. Fetuin-A is a glycoprotein produced in the liver and it is effective in the inhibition of bone mineralization, insulin resistance, obesity and calcification in smooth muscle. In the study conducted, it was aimed to investigate the relationship between the two substances in growth retardation, considering that Vitamin D and Fetuin-A are acting through similar mechanisms. The study was conducted with 50 healthy children with growth retardation. In short patients and underweight patients, vitamin D levels were found to be lower than control group (respectively p = 0,011 p = 0,036). As vitamin D value increased one unit, it was found that the risk of growth retardation decreased by 1,071 times (p = 0,21). Fetuin-A levels were higher in those with growth retardation (p = 0,035). In the preschool group, fetuin-A was higher than middle childhood (p < 0,001). In short patients, fetuin-A levels were higher than control groups (p = 0,043). There was a poor correlation between vitamin D and fetuin-A levels in those with growth retardation (rho: 0,366 p = 0,009). Fetuin-A levels were higher in short children and there was a positive relationship between vitamin D and fetuin-A levels in those with growth retardation. Vitamin D levels were lower in those with growth retardation.
Inhibitory action of mVOCs from Shewanella algae Sg8 against phytopathogenic fungi and transcriptional elicitation of PR genes in tomato
Authors: Subramanian Radhesh Krishnan , Kumaravel Sengali Ragunath , Sriniva Radhakrishnan , Prabakaran Narayanasamy , Kandasamy Keerthana Ponni , G Balaji , K Latha
Published: October 2022

The analysis of Microbial volatile organic compounds (mVOCs) is an emerging research field with huge impact in the fields of medical and agricultural biotechnology, mVOCs are being considered as imminent eco-friendly alternatives to chemical pesticides and fertilizers in sustainable agriculture. In this study, we characterized the effect of volatiles emitted from Shewanella algae (Sg8) isolated from a marine ecosystem in promoting plant growth, in controlling the activity of Fusarium oxysporum and its antagonistic activity against other phytopathogenic fungus. Sg8 inhibited the growth of four other agronomically important foliar and soil plant pathogens: Botrytis cinerea, Colletotrichum gloeosporioides, Magnoporthae oryzae and Macrophomina sp. The effect of mVOCs produced by the bacterium Sg8, on plant growth were investigated on tomato plants under in vivo conditions. The VOCs emitted from Sg8 up regulated the Thaumatin-like antifungal (PR-5) gene (9-fold) and Glutamine synthetase (GS) gene (0.96-fold) in tomato plants. Sg8 effectively inhibited the growth of F. oxysporum and possessed plant growth promoting (PGP) activity. Our results show that Sg8 generates bioactive volatiles that induces the regulation of Pathogenesis related (PR) genes, and stimulates the growth of the plants and also suppresses the growth of other agriculturally important foliar and soil phyto-pathogenic fungus.
Comparison between Oblique Lateral Interbody Fusion and Minimally Invasive Transforaminal Lumbar Interbody Fusion in Degenerative Lumbar Stenosis: An Age-, Sex-, and Segment-matched Cohort Study
Authors: Liu Lantao , Xue Hui , Han Zhiyuan , Jiang Lianghai , Chen Longwei , Wang Dechun
Published: October 2022

Objectives: To compare outcomes after oblique lateral interbody fusion (OLIF) versus minimally invasive transforaminal lumbar interbody fusion (MISTLIF) with bilateral decompression via unilateral approach for treating mild to moderate symptomatic degenerative lumbar spinal stenosis (DLSS).
Methods: We retrospectively compared patients who underwent single-level (L4/5) OLIF with an age-, sex-, and segment-matched MISTLIF with bilateral decompression via unilateral approach cohort. Perioperative data were collected for the operative time, intraoperative blood loss, drainage in the first postoperative day, postoperative hospital stay, cost, intraoperative fluoroscopy, and complications. Lumbar radiographs were measured for changes in posterior intervertebral space height (PISH), intervertebral space foramen height (IFH), intervertebral foramen area (IFA), and area of the spinal canal (ASC). Clinical and psychological outcomes included the visual analog scale (VAS), Oswestry Disability Index (ODI), and hospital anxiety and depression scale (HADS).
Results: 35 OLIF patients were compared with 35 MISTLIF patients in L4/5 DLSS. The OLIF group had shorter bedtime, postoperative hospital stays, less intraoperative and postoperative blood loss (all P<0.05), but had more times of intraoperative fluoroscopy, longer operative time, and higher cost (all P<0.05). The complication rates were equivalent (OLIF vs MISTLIF: 22.86% vs 17.14%). PISH (11.94±1.78mm vs 9.42±1.94mm, P<0.05), IFH (23.87±3.05mm vs 21.41±2.95mm, P<0.05), and IFA (212.14±51.82mm2 vs 177.07±51.73mm2, P<0.05) after surgery were significantly increased in the OLIF group. The ASC was increased significantly after the operation in both groups, but the ASC in the MISTLIF group was increased significantly more than that in the OLIF group (450.04±66.66mm2 vs 171.41±58.55mm2, P<0.05). The lumbar VAS scores at 1 month (1.89±0.87 vs 2.34±0.84, P=0.028) and 6 months (1.23±0.97 vs 1.80±0.99, P=0.018) after operation in the OLIF group were significantly lower. There were no significant differences in lower extremity VAS and ODI scores between the two groups. Compared with MISTLIF group, HADS scores on postoperative day 3 (2.91±1.46 vs 4.89±1.78, P<0.05) and prior to hospital discharge (PTD) (2.54±1.38 vs 3.80±1.78, P=0.002) in the OLIF group were decreased significantly.
Conclusions: OLIF showed more advantages of less surgical invasion, lower incidence of postoperative low back pain, faster postoperative recovery, and less anxiety compared with MISTLIF. Regardless of cost, OLIF seems to be a better option to treat mild to moderate symptomatic DLSS.
Thermodynamic Parameters of Phenylglycine Interaction with UO22+, La3+ and Zr4+
Authors: El-Dossoki Farid I. , Mohamed Abd Allah Abd El-Wahab
Published: October 2022

The interactions between phenylglycine and some transition metal ions (UO22+,La3+ and Zr4+) were studied at three ionic strengths [(µ = 0.05, 0.10 and 0.15) M KNO3] and three temperatures [(25, 35 and 45) ºC] in aqueous media by using Bjerrum’s potentiometric technique. The stoichiometric and thermodynamic stability constants as well as the degree of complexation for all studied systems (\(\stackrel{-}{\text{n}}\)) were determined and discussed. The standard thermodynamic parameters (Δ pKº and Δlog Kº) and the thermodynamic parameter differences (ΔGº, ΔΔGº, ΔHº, ΔΔHº, ΔSº, and ΔΔSº) were calculated for all possible reactions. Advanced discussions of these functions as well as the factors that may control the complexation processes from the thermodynamic point of view have been reported.
Push-pull behavior of 2,7-disubstituted sila- and germafluorenes
Authors: Jarrett-Noland Shelby J. , McConnell William , Braddock-Wilking Janet , Dupureur Cynthia M.
Published: October 2022

Push-pull dyes exhibit intramolecular charge transfer behavior, which due to changes in dipole moment upon excitation, is the origin of their environmental sensitivity. Such compounds are of interest as probes for bioimaging and as biosensors to monitor cellular dynamics and molecular interactions. Desirable biological probes absorb in the visible region, have high extinction coefficients, high quantum yields and excellent photostability. Fluorophores with scaffolding that can be used to tune and optimize solvatochromic behavior are of particular interest. Here we investigate the environmental sensitivity of a small library of highly fluorescent 2,7-disubstituted sila- and germafluorenes. Density functional theory calculations show that charge transfer occurs from the alkyne core out to the 2,7- and 3,6-methoxy substituents, the hallmark of push-pull behavior. They exhibit HOMO-LUMO energy gaps of about 3 eV with dipole moments ranging from 2-3.25 D. These compounds exhibit desirable Stokes shifts in various solvents, and the dependences of Stokes shift on solvent polarizability are consistent with solvatochromic behavior. With the ability to tune push-pull properties via the 2,7-substituent, these disubstituted sila- and germafluorenes have excellent potential as biological probes.
Structure of a duplex-embedded G-quadruplex system resolved to 7.4 Å resolution by cryo-EM
Authors: Monsen Robert , Chua Eugene , Hopkins Jesse , Chaires Jonathan , Trent John
Published: October 2022

Genomic regions with high guanine content can fold into non-B form DNA four-stranded structures known as G-quadruplexes (G4s). Extensive in vivo investigations have revealed that promoter G4s are transcriptional regulators. Little structural information exists for these G4s embedded within duplexes, their presumed genomic environment. Here we report the 7.4 Å resolution structure and dynamics of a 28.5 kDa duplex-G4-duplex (DGD) model system using cryo-EM, molecular dynamics, and small-angle X-ray scattering (SAXS) studies. The DGD cryo-EM refined model features a 53° bend induced by a stacked duplex-G4 interaction at the 5’ G-tetrad interface with a persistently unstacked 3’ duplex. The surrogate complement poly dT loop preferably stacks onto the 3’ G-tetrad interface resulting in occlusion of both 5’ and 3’ tetrad interfaces. Structural analysis shows that the DGD model is quantifiably more druggable than the monomeric G4 structure alone and represents a new structural drug target. Our results illustrate how the integration of cryo-EM, MD, and SAXS can reveal complementary detailed static and dynamic structural information on DNA G4 systems.
Transcriptional regulation profiling reveals PPARA-mediated fatty acid oxidation as a novel therapeutic target in phospholamban R14del cardiomyopathy
Authors: Harakalova Magdalena , Pei Jiayi , Maas Renee , Gaar-Humphreys Karen , Gho Johannes , Nagyova Emilia , Blok Christian Snijders , Adrichem Iris van , Es René van , Sepehrkhouy Shahrzad , Feyen Dries , Dungen Noortje van den , Lansu Nico , Calis Jorg , Kaaij Niels van der , de Jonge Nicolaas , Laake Linda van , Riele Anneline ter , Huibers Manon , de Weger Roel , Verhaar Marianne C. , Tintelen J. Peter van , Vaz Frederic , Burgering Boudewijn , Mil Alain van , Buikema Jan , Vink Aryan , Karakikes Ioannis , Mercola Mark , Doevendans Pieter AFM , Sluijter Joost , Steenbeek Frank van , Cheng Caroline , Mokry Michal , Asselbergs Folkert
Published: October 2022

Carriers of the R14del pathogenic variant in the phospholamban (PLN) gene develop severe cardiomyopathy with extracellular adipocyte infiltration and intracellular cardiomyocyte mitochondrial disturbances. However, the basis of this metabolic dysregulation tailoring potential treatment targets is unknown. Here, we present a combined approach of transcriptional regulation analysis in human primary tissue and validation in a unique long-term (160 days) matured human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) model. We demonstrate a dysregulated PPARA-mediated mitochondrial fatty acid oxidation (FAO) signalling in PLN-R14del hearts and hiPSC-CMs. PLN-R14del hiPSC-CMs also displayed a higher preference for glycolysis over FAO and presented limited flexibility in energy substrate switching leading to enhanced lipid droplet storage. By activating PPARA in PLN-R14del hiPSC-CMs using bezafibrate, we observed an improved mitochondrial structure and calcium handling function, further indicating the importance of FAO in the disease and the potential of PPARA agonists as a novel therapeutic strategy in cardiomyopathies.
Epidemiology of hand, foot, and mouth disease and genetic characteristics of Coxsackievirus A10 in Taiyuan City, Shanxi Province from 2016–2020
Authors: Wang Jitao , Liu Hongyan , Cao Zijun , Xu Jihong , Guo Jiane , Zhao Lifeng , Wang Rui , Xu Yang , Gao Ruihong , Gao Li , Zuo Zhihong , Xiao Jinbo , Lu Huanhuan , Zhang Yong
Published: October 2022

Background In recent years, the prevalence of hand, foot, and mouth disease (HFMD) caused by enteroviruses other than enterovirus A71 (EV-A71) and coxsackievirus A16 (CVA16) has gradually increased. The pathogen spectrum of HFMD also continues to change. In this study, we analyzed the epidemiological characteristics of HFMD and the genetic characteristics of the coxsackievirus A10 (CVA10) virus identified in Taiyuan City, Shanxi Province. Methods The epidemiological data from 2016–2020 on HFMD in Taiyuan City was collected from the China Information System For Disease Control and Prevention. The throat swab specimens of 2701 HFMD cases were tested, theVP1regions of CVA10 RNA were amplified using RT-PCR, and phylogenetic analysis of CVA10 was performed. The study results were analyzed using Pearson's Chi-Square Test. Results Children aged 1–5 years accounted for the majority (81.65%) of all HFMD cases, and the average annual incidence is higher in boys than in girls. Of the 2,701 specimens collected, 1,439 (53.28%) were positive for human enterovirus (EV). The positivity rates of EV-A71, CVA16, and other EVs were 15.22% (219/1439), 28.77% (414/1439), and 56.01% (806/1439), respectively. The proportion of specimens positive for other EVs was significantly higher than that of EV-A71 and CVA16. CVA10 is one of the important viruses of other EVs. A total of 52 CVA10 strains were used for phylogenetic analysis based on theVP1region. Of the 52 CVA10 strains, 31 were from this study, and 21 were downloaded from GenBank. All CVA10 sequences could be assigned to seven genotypes (A, B, C, D, E, F, and G), and genotype C was further divided into C1 and C2 subtypes. Of the 31 CVA10 strains identified in this study, only one belonged to subtype C1 and the remaining 30 belonged to C2. Conclusions This study emphasized the importance of strengthening the surveillance of the HFMD in order to understand the mechanisms of pathogen variation and evolution, so as to provide a scientific basis for HFMD prevention, control, and vaccine development.