bluuebunny/crossref_metadata_2025 huggingface dataset:
Decoding the Reaction Mechanism of the Cyclocondensation of Ethyl acetate 2-oxo-2-(4-oxo-4H-pyrido [1.2-a] pyrimidin-3-yl) polyazaheterocycle and Ethylenediamine using Bond Evolution Theory
Authors: Maraf Mbah , ADJIEUFACK Abel Idrice , MEKOUNG Pelagie MANWAL A , ZINTCHEM Auguste ABOUEM A , BEBGA . GOUET , Rhyman Lydia , Ibrahim Ndassa , Ramasami Ponnadurai
Published: November 2021

The bonding evolution theory has been used to investigate the flow of
electron density along the reaction pathways of ethyl acetate
2-oxo-2-(4-oxo-4H-pyrido [1.2-a] pyrimidin-3-yl) polyazaheterocycle
(1) and ethylenediamine (2). This reaction has three channels (1-3) and
each one takes place via three or four steps. DFT results reveal that
channel 2, which goes through imine intermediate is by far the most
favorable one, and the main product 3 is more stable than 4 and 5,
showing that this reaction is under kinetic and thermodynamic control,
in clear agreement with the experimental outcomes. The BET analysis
allows identifying unambiguously the main chemical events happening
along channel 2. For this reaction channel, the mechanism along the
first step (TS2-a) is described by a series of four structural stability
domains (SSDs), while five SSDs are required for the second (TS2-b) and
the third (TS2-c) one. The first step can be summarized as follow, the
appearance of V(N1,C6) basin illustrating the formation of N1-C6 bond
(SSD-II), the splitting of N1-H1 bond, followed by the restoration of
the nitrogen N1 lone pair (SSD-III), and finally, the formation of the
last O1-H1 bond (SSD-IV). For the second step, the formation of
hydroxide ion is noted, consequent of the disappearance of V(C6,O7)
basin, the transformation of C6-N1 single bond into double one (SSD-IV).
Finally, the appearance of V(O7,H2) basin leading to the elimination of
water molecule within the last domain. Overall, for the three reaction
steps, the formation of the N-C bond appears always before the O-H one.
NHC Ligated Oximes: Exploring the Electronic Structure and Properties
Authors: Dar Mohammad Ovais , Dubey Gurudutt , Singh Tejender , Bharatam Prasad
Published: November 2021

Compounds with (NHC)→E coordination bond are being generated and their
chemistry is being explored over the past 15 years (NHC=
N-heterocyclic carbenes, E = main group elements). Many examples
of species with N-heterocyclic olefins (NHOs) are known, which
exhibit umpolung chemistry. Increasing number of chemical species, which
carry NHC as a functional unit, are being reported. There is a need to
understand their electronic structure. Alkylated imidazole oximes
(cationic, found useful in medicinal chemistry) ((NHC)-C(H)=N-OH(+))
carry NHC unit as a functional group. Similarly, the corresponding
nitroso-N-heterocyclic olefins ((NHC)=C(R)-N=O) also carry NHC as
a functional unit. It is important to establish the interaction between
the NHC unit and the rest part of the molecule in these species. Density
functional (DFT) study has been carried out to explore the electronic
structure details of a few oximes and nitroso NHOs. The results indicate
that a structure with NHC→C coordination interaction can be considered
as one of the resonance structures of these species.
Intelligent Behavior Utilizing Light-weight Diagnosis
Authors: Zimmermann Martin , Wotawa Franz , Pill Ingo
Published: November 2021

Intelligence in its decisions is a trait that we have grown to expect
from a cyber-physical system. In particular that it makes the right
choices at runtime, i.e., those that allow it fulfill its tasks, even in
case of faults or unexpected interactions with its environment.
Analyzing how to continuously achieve the currently desired (and
possibly continuously changing) goals and adapting its behavior to reach
these goals is undoubtedly a serious challenge. This becomes even more
challenging if the atomic actions a system can implement become
unreliable due to faulty components or some exogenous event out of its
control. In this paper, we propose a solution for the presented
challenge. In particular, we show how to adopt a light-weight diagnosis
concept to cope with such situations. The approach is based on rules
coupled with means for rule selection that are based on previous
information regarding the success or failure of rule executions. We
furthermore present a Java-based framework of the light-weight diagnosis
concept, and discuss the results obtained from an experimental
evaluation considering several application scenarios. At the end, we
present a qualitative comparison with other related approaches that
should help the reader decide which approach works best for them.
ANCA-Associated Vasculitis Following Johnson and Johnson COVID-19 Vaccine
Authors: Yadav Rukesh , SHAH SANGAM , Chhetri Santosh
Published: November 2021

Antineutrophil cytoplasmic autoantibodies associated vasculitis(AAV) is
characterized by antibodies against antigens in cytoplasmic granules of
neutrophils and predominantly affects small vessels. AAV after COVID-19
mRNA vaccination has been reported. We report rare case of AAV in a
patient who presented with rapidly progressive glomerulonephritis(RPGN)
after Johnson & Johnson vaccine administration.
SPEECH AND CAMPUS INCLUSIVITY
Authors: Flanigan Jessica , Greven Alec
Published: November 2021

University administrators should not enforce speech codes because speech codes are generally counterproductive to a university’s educational mission. In making the case against campus speech codes, we consider and reply to four of the most prominent arguments in favor of restricting student speech. These arguments appeal to the values of harm prevention, inclusive education, relational equality, and the overall promotion of free speech. We show that speech restrictions do not effectively promote these values. We conclude that campus administrators should uphold protections for freedom of expression on college campuses in order to promote a more egalitarian and inclusive learning environment.
Concepts of Beta-Cell Organ Dysfunction and Failure Would Lead to Earlier Diagnoses and Prevention
Authors: Charles M. Arthur , Leslie R. David
Published: November 2021

As the
world endures a viral pandemic superimposed on a diabetes pandemic, the latter
incorporates most of the comorbidities associated with the former, thereby
exacerbating risk of death in both. An essential approach to both pandemics is
prevention and unrealized earlier treatment. Thus, in this Perspective relating
to diabetes we emphasize a paradigm of first, reversible beta-cell organ
dysfunction (BCOD) and then irreversible beta-cell organ failure (BCOF), which
directly indicate the potential for earlier prevention, also unrealized in
current guidelines. Four pillars support this paradigm: epidemiology,
pathophysiology, molecular pathology, and genetics. A substantial worldwide
knowledge base defines each pillar and informs a more aggressive preventive approach
to most forms of the disorder. This analysis seeks to clarify the temporal and
therapeutic relationships between lost beta-cell function and content,
illuminating the potential for earlier diagnoses and thus, prevention. We also
propose that myriad pathways leading to most forms of diabetes converge at the endoplasmic
reticulum, where stress can result in beta-cell death and content loss.
Finally, genetic and nongenetic origins common to major types of diabetes can
inform earlier diagnosis and potentially, prevention, with the aim of
preserving beta-cell mass.
Coincidences and Konstatierungen. Aspects of Methodological Creativity in Schlick's Science-Oriented Philosophizing
Authors: Max Ingolf
Published: November 2021

Moritz Schlick (1882–1936)—the integrating figure of the Vienna Circle—is an inspiring thinker who philosophizes in the immediate vicinity of contemporary physics in particular and other empirical sciences including psychology as well as ethics. In the context of interpreting Einstein’s (general) theory of relativity he wrote his „Space and time in contemporary physics, an introduction to the theory of relativity and gravitation“ [“Raum und Zeit in der gegenwärtigen Physik: zur Einführung in das Verständnis der Relativitäts- und Gravitations­theorie”]—first published in 1917. Schlick developed his conception of space-time coincidences of events. For the second edition he added the new chapter “X. Relations to Philosophy” using coincidences methodologically to connect terms which belong to different spaces of meaning. Starting in 1934—in the context of the debate on protocol sentences mainly with Otto Neurath and Rudolf Carnap—he offered his approach of Konstatierungen[1] to answer the question: “What is to be regarded as our fundament of knowledge?” I will shortly discuss Schlick’s term coincidence, move on to Konstatierungen and show some interrelations between them. I will argue for the methodological creativity in Schlick’s science-oriented philosophizing by explicating the inner structure of Konstatierungen within my 2-dimensional language of analysis. Finally, I will compare Schlick’s Konstatierungen with Kant’s synthetic a priori judgments and Frege’s thoughts as interrelated cases of two-dimensionally structured intermediate cases.
Evaluasi mutu susu segar dari peternak berbeda di provinsi Lampung sebagai bahan baku keju
Authors: Yuliana Neti , Indrawan Iyan , Wirawati Chandra Utami , Sumardi Sumardi
Published: November 2021

The objective of this study was to evaluate the quality of fresh cow’s milk from different farmers in Lampung Province as a raw material for cheese in view of the Indonesian National Standard SNI 31411 (2011) regulation.  Twelve fresh milk samples from four different districts (Tanggamus, Metro, Gisting, and Pesawaran) were evaluated by estimation of total protein and fat, pH, alcohol test, total plate count, antibiotic residues, and sensory. The result of the study revealed that the samples had protein and fat ranged from 2.44 to 3.90 %, and from 3.48 to 4.73% (wet basis) respectively.  The fresh milks had normal sensory and pH, negative of alcohol test, and free from antibiotic residues. Total microbes were detected in log 5-6 CFU/ml.  Majority of the samples screened met the Indonesian National Standard and could be used as a raw material for cheese making.  Keywords:  cheese,  fresh milk quality, Lampung province, SNI 31411,
GOOD SALES FORECASTING INFORMATION SYSTEM USING SINGLE EXPONENTIAL SMOOTHING METHOD
Authors: Darwas Rahmadini , Rahimullaily Rahimullaily , Abdi Naufal
Published: November 2021

This study aims to determine the estimated number of items sold at one of the mini market, namely the Tita shop, especially Sari Murni cooking oil, 2 liter packs for the next one month based on sales data for January 2016 to December 2017. The problems that occur at Tita`s shop are is difficult to estimate the amount of stock of goods and calculate the estimated cost required for sales in the next month period, so it is necessary to build a forecasting information system using the single exponential smoothing method which assumes that the data fluctuates around the mean value without any trend or seasonal elements. This study resulted in the amount of 2 liter packaged sari murni cooking oil in Januari 2018, which was 42 pcs. Meanwhile, the estimated cost required to buy 2 liter packaged cooking oil stock in that period is Rp. 609.000,00 with a capital price unit of goods Rp. 14.500,00.
ANALYSIS OF THE USE OF THE BEBUNGE APPLICATION USING END USER COMPUTING SATISFACTION MODEL
Authors: Setyadi Resad , Baqi Muhammad Hamzah
Published: November 2021

The Bekasi district Government already has an integrated service application, namely Bebunge or Bekasi Nyambung Bae. This application is the beginning of a part of the Bekasi district plan to prepare Bekasi for a Smart City. Through the Bebunge application, Bekasi residents can get information for population needs. However, to what extent is the satisfaction of Bekasi society with the Bebunge application so that the Bekasi government can get an evaluation of application usage by looking at the level of user satisfaction. This study analyzes the level of user satisfaction of the Bebunge application using the End User Computing Satisfaction (EUCS) model. The questionnaire analysis method uses inferential statistical analysis with Smart PLS media. Based on the guidelines for the level of satisfaction, the results of the study show that if the satisfaction level of Bekasi society is at an average value of 3.45, which is at level 4, it means that Bekasi society generally uses the Bebunge application with moderate intensity and find the Bebunge practical application. The recommendation for the Bebunge application is that additional features are needed to access job vacancies, information on the latest status updates for COVID-19 in Bekasi, and an Update on the status of the COVID-19 zone in Bekasi. The contribution of this study is to improve the functionality of the Bebunge application for Bekasi society. The second contribution of this study is to become a reference for researchers from the subdomain of smart cities, namely smart society
Recombinant adeno-associated viruses as a gene delivery vehicle for the use in molecular medicine
Authors: Usman NYu , Rebrikov DV
Published: November 2021

Viral mechanisms for the delivery of genetic material are widely used in molecular medicine. Recombinant adeno-associated viruses (rAAV) represent a promising tool for in vivo gene delivery. The review considers nosological spectrum, molecular mechanisms, the choice of drug administration route depending on target structures, the choice of serotype, and the methods of active ingredient manufacturing for rAAV-mediated gene therapy.
IMPACT OF COVID-19 ON CRYPTOCURRENCIES: EVIDENCE ON INFORMATION TRANSMISSION THROUGH ECONOMIC AND FINANCIAL MARKET SENTIMENTS
Authors: Shakri Irfan Haider , Yong Jaime , Xiang Erwei
Published: November 2021

This paper investigates the relationship between the COVID-19 crisis and the two leading cryptocurrencies, Bitcoin and Ethereum, from 31 December 2019 to 18 August 2020. We also use an economic news sentiment index and financial market sentiment index to explore the possible mechanisms through which COVID-19 impacts cryptocurrency. We employ a VAR Granger Causality framework and Wavelet Coherence Analysis and find the cryptocurrency market was impacted in the early phase of the sample period through economic news and financial market sentiments, but this effect diminished after June 2020.
Park, J., Scott, K., York, D. & Carnahan, M. (2019) Haemophilia in Aotearoa New Zealand. More than a bleeding nuisance. Abingdon: Routledge.
Authors: Benseman John
Published: November 2021

NA
Renewing Community Infrastructure: a case study of the Building one community consultation
Authors: Woodley Alex , Tupou Janet
Published: November 2021

A case study is provided of a community needs assessment of Point Chevalier community assesses the interest of the community in retaining the BuildingOne as a community arts center.
Înființarea secției de geografie și a institutului său din cadrul Facultății de Științe de la Universitatea Daciei Superioare din Cluj
Authors: Păcurar Alexandru
Published: November 2021

"The setting up of the Geography Department and its Institute within the Faculty of Sciences at the Upper Dacia University of Cluj. On 16 August 1919, the University Board, the organ created for the organization and employment of teaching staff for the Upper Dacia University of Cluj after its transition to Romanian administration (12 May 1919), presented and proposed the organisational chart by departments, seminars, laboratories and institutes of the future Faculty of Sciences, by means of the Board rapporteurs, scientists Gheorghe Țițeica, Ludovic Mrazec and Alexandru Borza. At the express request of professor George Vâlsan, the tertiary geographical education was also included in this Faculty, as an independent department, the Department of Geography, consisting of two sections and an Institute of Geography. This was a new situation, different from the study of Geography at the universities in Iași and Bucharest. The organisational chart of Cluj University, made according to the ”German model”, was kept until the Stalinist reform of the Romanian education on 3 August 1948. By means of suggestive examples, the main Romanian university institutions newly-created at Cluj University are illustrated and described, some of them under the auspices of the Royal Foundations, such as the Astronomic Observatory and the Institute of Chemistry and Physics, as well as others, like the Sports Park, the new Botanical Garden with the Botanic Museum, the Palace of University Clinics, the Academic College and the Ethnographic Park and Museum. The materialization of George Vâlsan’s concept regarding the study of Geography and its relations to the other departments of Cluj University, as well as the their scientific and logical foundation within the double specialization, are extensively presented, as a proof of the scientist’s determination to lay solid grounds to the Romanian tertiary geographical education at Cluj University.

Keywords: Upper Dacia University of Cluj, Geography Department, Faculty of Sciences.
"
The Implementation of Islamic Education in Building Preprimary Disabled Students Character
Authors: Sutejo Edi , Nurdin Nurdin , Syahid Ahmad
Published: November 2021

This study examined the implementation of Islamic education in building preprimary disabled students characters. The main focus of this study was teachers strategies in building characters for mentally retarded children in the subject of Islamic religious education and character.  In conducting the study, we used a qualitative case study method. The case of this study was a state disabled in Palu city. Data were gathered through direct field observation, in-depth interviews which involve teachers and the school principla. We also analyzed written material, such as the school teaching activities, to understand how the character building strategies were integrated in the disabled school curriculum.  Our study found that the teacher's strategies in building character of mentally retarded children in the subject of Islamic Religious Education were through habituation and modeling techniques. The teachers of Islamic religious education applied  learning habits that contain good values ​​and attitudes. This included familiarizing with habits to maintaining cleanliness, Quran recitation, practicing prayers, and getting used to giving donation.
Template assisted nano-structured nickel for efficient methanol oxidation
Authors: Mohanapriya S , Raj V
Published: November 2021

Nanoporous nickel has been prepared by electrodeposition using non-ionic surfactant based liquid crystalline template under optimized processing conditions. Physicochemical properties of nanoporous nickel are systematically characterized through XRD, SEM and AFM analyses. Comparison of electrocatalytic activity of nanoporous nickel with smooth nickel was interrogated using cyclic voltammetry (CV), chronoamperometry (CA) and electrochemical impedance spectroscopy (EIS) analyses. Distinctly enhanced electrocatalytic activity with improved surface poisoning resistance related to nanoporous nickel electrode towards methanol oxidation stems from unique nanoporous morphology. This nanoporous morphology with high surface to volume ratio is highly beneficial to promote active catalytic centers to offer readily accessible Pt catalytic sites for MOR, through facilitating mass and electron transports.
The moratorium on loan repayments during the Covid-19 Pandemic in Europe: a comparative analysis of loan moratoria in selected European countries
Authors: SKRABKA Jan
Published: November 2021

This paper examines the moratorium on loan repayments, which was intended to relieve debtors in a difficult situation during the COVID-19 pandemic. In this study, various aspects of such moratoria are critically discussed and compared from an international perspective. Some debtors were significantly hit hard by the pandemic, whereas others were no. But should the moratoria apply to all of them? The free-rider problem, or even harm to some clients, are among the unintended results of the moratorium. Moreover, the loan repayment moratorium has different effects on the traditional banking sector and on P2P lending platforms. Such differences were not discussed sufficiently before adopting the moratoria. The different effects might have a negative impact on some debtors, on some creditors, or on the market and society in general. Along with using some traditional legal research methods, this paper takes a comparative perspective on loan repayment moratoria in different EU countries among. The conclusions of the paper may help regulators and lawmakers prepare more balanced regulations of loan repayments in the next crisis. Future regulations should reflect the perspectives of both debtors and creditors.
Pemanfaatan Kacang Merah dan Ubi Jalar Putih sebagai Bahan Bolu Kukus
Authors: Agustina Novia , Fitriani Shanti
Published: November 2021

The steamed cake is one of the popular foods. It has a good taste, a soft texture, a sweet taste, and varies in shape. The steamed cake in this study was made from red bean flour and white sweet potato flour. The purpose of the utilization of red bean flour and white sweet potato flour is to diversify food products. The purpose of this research was to formulate the red bean flour and white sweet potato flour imparting the best-steamed cake’s quality. A completely randomized design (CRD) with five treatments and three replications was applied. The treatment was the red bean flour and white sweet potato flour ratios, namely KUJ1 (80:20), KUJ2 (70:30), KUJ3 (60:40), KUJ4 (50:50), and KUJ5 (40:60). The data obtained were analyzed statistically using analysis of variance (ANOVA) and followed by Duncan's Multiple Range Test (DMRT) at the 5% level. The results showed that the ratios of red bean flour and white sweet potato flour significantly affected chemical (moisture content, ash content, protein content, fat content, carbohydrate content, crude fiber content) parameters but did not significantly influence sensory test parameters (descriptive and hedonic). The best quality was developed by the KUJ1(80:20) formulation which constituted: moisture of 33.86%, ash content of 1.19%, the protein content of 9.74%, the fat content of 1.09%, the carbohydrate content of 54.13%, and crude fiber content of 12.34% with a description of brownish-white, between red beans and sweet potatoes aroma, the taste between red beans and sweet potatoes and soft tenderness, liked by the panelist.
Identifikasi Unsur Hara Sulfur pada Sistem Irigasi Primer di Tanah Sawah Wilayah Bendungan Arca Kiri, Kabupaten Banyumas
Authors: Agustine Leony , Wibowo Amanullah Thaariqa Tri , Begananda Begananda
Published: November 2021

Penelitian ini bertujuan untuk mengetahui: 1) besarnya kandungan unsur hara Sulfur di tanah sawah, Wilayah Bendungan Arca Kiri, Kabupaten Banyumas, 2) agihan unsur hara Sulfur di tanah sawah, Wilayah Bendungan Arca Kiri, Kabupaten Banyumas, dan 3) rekomendasi takaran pupuk Sulfur di tanah sawah, Wilayah Bendungan Arca Kiri, Kabupaten Banyumas. Penelitian dilaksanakan di tanah sawah, Wilayah Bendungan Arca Kiri, Kabupaten Banyumas, dan dilanjutkan dengan analisis tanah di Balai Pengkajian Teknologi Pertanian (BPTP), Yogyakarta. Penelitian dilaksanakan pada bulan September sampai November 2015. Penelitian dilakukan dengan penetapan titik sampel yang didasarkan pada sistem purposive random sampling atas dasar Satuan Lahan Homogen (SLH). Satuan Lahan Homogen disusun dengan menumpangsusunkan (overlay) Peta Administrasi, Peta Kelerengan, dan Peta Jenis Tanah. Jumlah sampel adalah 8 yang terletak di 5 desa. Variabel yang diamati meliputi kandungan unsur hara Sulfur, DHL, pH (H2O), dan KB tanah. Hasil penelitian menunjukkan bahwa kandungan unsur hara Sulfur di kedua SLH tergolong tinggi, yaitu pada SLH A1 mencapai 86,20 ppm dan SLH A2 mencapai 85,33 ppm. Rekomendasi takaran pupuk Sulfur untuk SLH A1 adalah 10,64 kg S/ha dan SLH A2 adalah 14,60 kg S/ha.
FEAR OF COVID-19 PADA KARYAWAN YANG BEKERJA SECARA LURING SELAMA PANDEMI
Authors: Nelsen Kevin Leo , Sahrani Riana
Published: November 2021

The year 2020 begins with the COVID-19 pandemic, because of the sudden pandemic, many individuals are unable to adapt to the situation, moreover, the COVID-19 pandemic has an impact on many fields, from the health sector (medical) to the field. offices. COVID-19 spreads very quickly and caused panic. The government is doing its best to reduce the number of positive cases of COVlD19 in Indonesia. Some people are worried about the invisible threat of COVID-19. From this excessive anxiety, a new phenomenon has emerged, namely the fear of COVID-19. The purpose of this study is to provide an overview of the fear of COVID-19 among employees who work offline during the pandemic in the Jakarta area. Convenience sampling was used to collect data, and involved 173 participants who filled out questionnaires online. These participants are employees or workers from various professions who still have to work outside the home with an age range of 17-49 years. The results of data analysis in this study indicate that employees who work offline during the pandemic are 36 people (20.8%) classified as having a low level of fear of COVID-19, 109 people (63%) are classified as moderate, and 109 people are classified as high. 28 people (16.2%). So, it can be said that the level of fear of COVID-19 of employees working offline during the pandemic in the Jakarta area is fairly moderate. Tahun 2020 diawali dengan pandemi COVID-19, karena pandemi yang datang secara tiba-tiba, banyak sekali individu yang tidak dapat beradaptasi dengan situasi, terlebih, pandemi COVID-19 berdampak pada banyak sekali bidang, mulai dari bidang kesehatan (medis), hingga bidang perkantoran. COVID-19 menyebar dengan sangat cepat dan sempat membuat kepanikan. Pemerintah melakukan yang terbaik untuk menekan jumlah kasus positif COVID-19 di Indonesia. Sebagian orang merasa cemas akan ancaman COVID-19 yang tidak terlihat. Dari rasa cemas yang berlebihan itu, munculah fenomena baru, yaitu fear of COVlD19. Tujuan dari penelitian ini adalah untuk memberikan gambaran umum fear of COVID-19 pada pegawai yang bekerja secara luring (luar jaringan) selama pandemi di daerah Jakarta. Teknik pengambilan data dilakukan dengan convenience sampling, dan melibatkan 173 partisipan yang mengisi kuisioner secara online. Partisipan ini adalah pegawai atau pekerja dari berbagai profesi yang tetapharus bekerja di luar rumah dengan rentang umur 17-49 tahun. Hasil analisis data pada penelitian ini menunjukan bahwa pegawai yang bekerja secara luring selama pandemi yang tergolong memiliki tingkat fear of COVID-19 rendah berjumlah 36 orang (20.8%), partisipan yang tergolong sedang berjumlah 109 orang (63%, dan partisipan yang tergolong tinggi berjumlah 28 orang (16.2%). Jadi, dapat dikatakan bahwa tingkat fear of COVID-19 para pegawai yang bekerja secara luring selama pandemi di daerah Jakarta terbilang sedang.
DUKUNGAN SOSIAL SEBAGAI MEDIATOR PENGARUH RASA SYUKUR TERHADAP KEPUASAN HIDUP GURU PADA SAAT PEMBELAJARAN DARING
Authors: Tarihoran Yulia Lestari , Heng Pamela Hendra , Tiatri Sri
Published: November 2021

The Covid-19 pandemic resulted in new policies, one of which was to maintain physical distance.The application of maintaining physical distance has a huge impact in the world of education.This is due to the introduction of an online learning system. Teachers are the most affected.In desperate circumstances, teachers are required to transform face-to-face learning systems into online learning.Changes that occur suddenly affect the satisfaction of the teacher's life as a professional educator.No exception occurs in elementary school teachers.The difficulties experienced with the implementation of online learning systems cause discomfort.One way to reduce teacher discomfort is to practice gratitude.This study examined whether social support acted as a mediator of the influence of gratitude on the life satisfaction of elementary school teachers in South Tangerang.Life satisfaction measurements use the Satisfaction with Life Scale (SWLS) adaptation scale.Social support uses the Multidimentional Scale of Perceived Social Support (MSPSS) adaptation scale Zimmet (1988).The adaptation scale of the Gratitude Questionnaire-Six Item Form (GQ-6) is used to measure gratitude.The results proved that social support mediated the influence of gratitude on life satisfaction in 125 elementary teachers in South Tangerang.The results support previous research in Korea (You et al., 2018), conducted on settings (COVID-19 pandemic) and different cultures. Pandemik Covid-19 menghasilkan kebijakan baru, salah satunya adalah menjaga jarak fisik. Penerapan menjaga jarak fisik sangat memiliki dampak dalam dunia pendidikan. Hal ini berimbas dengan diberlakukannya sistem pembelajaran daring. Guru merupakan pihak yang paling terkena dampak. Dalam keadaan terdesak, guru dituntut untuk mentransformasi sistem pembelajaran tatap muka menjadi pembelajaran daring. Perubahan yang terjadi secara tiba-tiba memengaruhi kepuasan hidup guru sebagai tenaga pendidik profesional. Tidak terkecuali terjadi pada guru Sekolah Dasar. Kesulitan yang dialami dengan pemberlakuan sistem pembelajaran daring mengakibatkan ketidaknyamanan. Salah satu cara yang dilakukan untuk mengurangi ketidaknyamanan guru adalah melatih rasa syukur. Penelitian ini menguji apakah dukungan sosial berperan sebagai mediator pengaruh rasa syukur terhadap kepuasan hidup guru SD di Tangerang Selatan. Pengukuran kepuasan hidup menggunakan skala adaptasi Satisfaction with Life Scale (SWLS). Dukungan sosial menggunakan skala adaptasi Multidimentional Scale of Perceived Social Support (MSPSS) Zimmet (1988). Skala adaptasi dari Gratitude Questionnaire-Six Item Form (GQ-6) digunakan untuk mengukur rasa syukur. Hasil penelitian membuktikan bahwa dukungan sosial memediasi pengaruh dari rasa syukur terhadap kepuasan hidup pada 125 guru SD di Tangerang Selatan. Hasil penelitian mendukung penelitian sebelumnya di Korea dilakukan pada setting (pandemik COVID-19) dan budaya berbeda.
Тrophic structures and the specifcs of paleocoenosis of the Middle-Upper Carboniferous skeletal mounds on the Shchuger River (Northern Urals)
Authors: Matveeva N. A. , Ivanova R. M.
Published: November 2021

Research subject. Organogenic structures such as the Moscowian-Kasimovian skeletal mounds from the Verkhnie vorota section on the Shchuger River (Northern Urals). Materials and methods. The lithological-paleoecological analysis of biohermal limestones and the determination of their fauna in thin sections (60 samples) and polished slabs (10 samples) taken in outcrops 39 on the Shchuger River, 89 m thick. Results. It is revealed that the Middle-Upper Carboniferous skeletal mounds were characterized by a three-level food chain at three stages of their development. Cyanobacteria, calcimicrobes and green algae were the suppliers of organic matter. Their further consumers were bryozoans, brachiopods, fusulinids, small foraminifera and bacteria. Omnivores and predators were absent. It is found that, heterotrophs were the most common organisms at the stabilization stage, while autotrophs were typical of the colonization stage. The paleocenoses of the Kasimovian skeletal mound had a more extensive composition. Here, each developmental stage was represented by two types of paleocenosis, compared to the Moscowian mound. Conclusions. It is found that the main external abiotic factors that controlled the development of the biocenosis in the sites under study were the hydrodynamic regime and sea level ﬂuctuations. An important internal factor was the development of bio-induced cement on the skeletons of organisms, which contributed to the formation of solid frameworks of buildings. Another internal factor was the widespread occurrence of Anchicodiaceae algae, which caused a decrease in the biodiversity of other groups of organisms. The data obtained allowed us to conclude that a shallow sea basin with a good aeration and low hydrodynamic regime existed in this area in the MiddleLate Carboniferous. A decrease in the basin area in the Late Carboniferous was manifested by a reduction in not only algal taxa, but also the biodiversity of the entire ecosystem.
Deformations of weakly lithifed rocks of the Bazhenov-Georgievsky complex
Authors: Grishkevich V. F. , Shaikhutdinova G. Kh. , Lagutina S. V.
Published: November 2021

Research subject. Deposits of the Upper Jurassic Bazhenov-Georgievsky complex situated in central West Siberian regions. At a frst approximation, the deposits are represented by interlayering pure or carbonatized radiolarites and organic-clay mixites. Materials and methods. A collection of core samples taken from the deposits was analyzed to study the geological and geophysical features of borehole sections, photographs of core samples, and micrographs of thin section. Soft sediment deformations, which appeared within the Bazhenov-Georgievsky complex as a result of earthquakes, were investigated using data obtained by Chinese researchers. Results. It is shown that, at diﬀerent stages of diagenesis, layers with sharply diﬀering density and mechanical properties came into contact, which led to various deformations of weakly lithifed layers during earthquakes. In the early and middle diagenesis, mobile carbonated radiolarites deformed plastic clay interlayers with the formation of carbonate nodules. In the middle diagenesis, in radiolarites, areas of weak lithifcation and mobile radiolarites coexisted. Along with plastic deformations, the processes of autobrecciation and autoﬂuid fracturing of radiolarites, abrasion erosion of the boundaries of clayey varieties took place. In the late diagenesis, lithifed varieties predominated in radiolarites and clayey silicites; as a result of deformations, radiolarites and the argillaceous bridges separating them were transformed into fragments, polished surfaces, and pellets. If, under the inﬂuence of diﬀerential loads, ﬂuidization (softening) and movement of weakly lithifed radiolarites occurred, then the rates of such movements in adjacent layers inevitably diﬀered. Each of the described cases is demonstrated by the core material of specifc boreholes and petrographic thin sections. The scale of the phenomenon is shown from the signs of loading of millimeter interlayers to pressure shafts of brecciated limestones with a thickness of 7–10 m. Conclusions. The West Siberian Plate is epicontinental; therefore, the most intense earthquakes occurred at consolidated basement block boundaries during isostatic subduction and compensations in the Neocomian clinoform ultrafast sedimentation zones. Soft sediment deformations occurred within the Bazhenov-Georgievsky layers recorded the rock history of intense seismic events of the past, their temporary and spatial distribution.
Seismic process on the Krillon Peninsula (Sakhalin Island) after the earthquake on April 23, 2017
Authors: Zakupin A. S. , Boginskaya N. V. , Kostylev D. V.
Published: November 2021

Research subject and methods. The seismicity of the Krilyon Peninsula (Sakhalin Island) after the earthquake on April 23, 2017 (M = 5.0) during the 2018–2021 period was investigated by the method of self-developing processes (SDP).

Results. The seismic activity showed a damping trend after the earthquake (and several following aftershocks), with the activation of SDP seismicity observed in two cases. In the study area (40 km within the radius from the epicenter of the Krillon earthquake) and its immediate vicinity (up to 80 km), earthquakes with M = 3.9 and M = 4.3 were observed 74 and 26 days after seismic activations. These earthquakes are considered to be the strongest events occurred in the study area in the period under consideration. The results of the study were compared with the monitoring data of the Kamchatka branch of the Geophysical Survey Russian Academy of Sciences (KB GS RAS) on the volumetric activity of subsoil radon (OA Rn). It was revealed that the OA Rn anomalies detected in November 2018 and January 2020 had appeared several weeks after the identifed SDP. The anomalies were registered at observation points remote from the study area (as well as from the above-mentioned earthquakes) by no more than 50 km. Earthquakes in 2018 (M = 3.9) and 2020 (M = 4.3) occurred 19 and 32 days after the appearance of OA Rn anomalies. In general, the current situation can be assessed as calm, since, according to the analysis data, the seismic activity has no prerequisites for the transition from the decaying stage to the stage of stabilization. As shown in the work, this is a sign for preparing an earthquake with a magnitude higher than 5. Nevertheless, activation and (as a result) earthquakes of moderate strength (M < 5) are possible on a damping trend. Conclusion. It is proposed to take into account the self-developing processes of activation as a primary sign for a change in the geodynamic state of the environment, under which the appearance of OA Rn anomalies is possible. These anomalies are associated with the forecast of moderate seismicity during foreshock or aftershock activations.
THEORETICAL FOUNDATIONS FOR THE MODULAR STRUCTURE OF THE PROGRAM FOR THE DEVELOPMENT OF INTERNATIONAL ACADEMIC MOBILITY AT A UNIVERSITY
Authors:   Armavir State Pedagogical University, Aldakimova O.V. , Oleshko T.I. ,   Armavir State Pedagogical University
Published: November 2021

Statement of the problem. The need to successfully fulfill the targets of the national project entitled “Development of the export potential of the Russian education system” emphasizes the importance of broad interdisciplinary studies of international academic mobility as a factor of strengthening Russian influence in the world. The analysis of statistical data presented in the scientific literature of the research results confirms the presence of a number of educational and managerial problems at universities that restrain the influx of students from foreign countries to Russian universities. The purpose of the article is to theoretically substantiate the modular structure of the international academic mobility development program at a university. Methodology (materials and methods). The methodological basis of the research is a systematic approach that allows us to consider international academic mobility as a complex multidimensional phenomenon with internal integrity. The reliance on a multi-context approach ensures that the system of factors affecting the development of international academic mobility in universities is taken into account. Research results. The scientific novelty and theoretical significance of the results obtained lies in the substantiation of the modular structure of the program for the development of international academic mobility at a university, including conceptual-strategic, administrative-managerial, scientific-methodological and psychological-advisory modules. The practical significance of the results obtained is determined by the possibility of their use in university practice for analyzing existing experience and planning new directions for development of international academic mobility at a university. Conclusion. The development of a comprehensive program for the development of international academic mobility will allow universities to move from isolated events to the implementation of a scientifically based strategy for strengthening leadership positions in the international arena.
MATHEMATICAL TRAINING OF SCHOOLCHILDREN AND STUDENTS IN THE REPUBLIC OF TYVA UNDER THE CONDITIONS OF BILINGUALISM
Authors:   Tuva State University, Saaya S.K. , Tanzy M.V. ,   Tuva State University, Safonov K.V. ,   Siberian State University of Science and Technology named after M.F. Reshetnev, Shershneva V.A. ,   Siberian Federal University
Published: November 2021

Statement of the problem. The article deals with the issue of the peculiarities of the formation of mathematical training of schoolchildren and students of the Republic of Tyva. The problem is caused by the bilingualism that has historically developed in the Republic: education at the university is conducted in Russian, while a significant part of students who have come from remote regions of Tuva do not speak Russian well, which complicates the acquisition of educational material.In this regard, the problem of developing a mathematics course for university students is actualized which would take into account the specifics of Tuvan-Russian bilingualism. The purpose of the article. The aim of the article is to provide guidelines for the development of an adaptive e-learning course in mathematics for engineering students, taking into account the level of Russian language proficiency by junior students. Methodology (materials and methods). The research methodology is based on the analysis of the features of Russian-Tuvan bilingualism, which affect the process of mathematical preparation of schoolchildren and students of the Republic from the standpoint of a competence approach and taking into account both the ethnopedagogical specifics of modern education and existing approaches in the field of adaptive learning in electronic educational systems. Research results. The issue of mathematical training of schoolchildren and students of Tuva has been analyzed from the standpoint of the Tuvan-Russian bilingualism historically formed in the Republic of Tuva. It is shown that the insufficient level of Russian language proficiency by junior students is a certain obstacle to studying mathematics at university. To teach future engineers mathematics it is proposed to develop and use an adaptive e-learning course in this subject, capable of taking into account, among other things, the student’s current level of Russian language proficiency. Conclusion. The author recommendations on the development of an adaptive e-learning course, which have the ability to take into account the level of students’ Russian language proficiency, proposed in the article, can be implemented when creating such a course focused on the formation of the mathematical competence of students – future engineers studying at Tuva State University.
Ichthyosis (concept, pathohistology, clinical picture, treatment)
Authors: Takhtarova Tatyana Gennadyevna , Khismatullina Zarema Rimovna , Panova Lyudmila Dmitrievna , Panova Anastasia Nikolaevna
Published: November 2021

Ichthyosis is a skin disease that is hereditary, has pronounced symptoms in the form of a violation of the skin, and the presence of formations resembling fish scales. It is possible to distinguish different approaches to the definition of ichthyosis, based on the modern study of this issue. Ichthyosis is classified by type: congenital and acquired. Congenital ichthyosis has its own classification depending on the manifestation of changes in the skin, the course of the disease, concomitant pathologies. Congenital ichthyosis is divided into ordinary (vulgar autosomal dominant, simple) ichthyosis, lamellar ichthyosis (dry ichthyosiform erythroderma, "collodion child", lamellar ichthyosis), X-linked ichthyosis (ichthyosis associated with the X chromosome, blackening ichthyosis), congenital bullous ichthyosiform erythroderma (erythroderma Broca's disease, ichthyosiform epidermolytic hyperkeratosis), fetal ichthyosis (intrauterine ichthyosis, universal hyperkeratosis, "Harlequin fetus", congenital keratosis), other congenital ichthyosis. Ichthyosiform conditions (the so-called acquired ichthyosis) are divided into symptomatic, age-related (senile), discoid ichthyosis. The causes of acquired ichthyosis can be various diseases, taking medications, improper skin care, unbalanced nutrition. Each form of ichthyosis differs by the type of inheritance, prevalence in the population, clinical picture, verified by histological examination of skin biopsies and electron microscopic examination of the skin. It may be accompanied by seasonality of exacerbation of the clinical picture, association with other diseases (allergic, diseases of the gastrointestinal tract, congenital malformations). There is no specific treatment for ichthyosis. In systemic therapy, derivatives of vitamin A are used, keratolytics, as well as moisturizing and emollient agents are used for external treatment. The use of therapeutic baths, general ultraviolet irradiation is effective.
The role of local retinoids in eliminating signs of skin aging
Authors: Albanova Vera I.
Published: November 2021

Skin aging is a complex process involving both internal (chronological aging) and external (biological aging) factors. Slowing down the proliferative and immune processes in the epidermis, reducing the activity of fibroblasts and vascularization of the dermis during chronological aging lead to thinning, dryness, hypersensitivity, vulnerability and superficial wrinkles. Exposure to ultraviolet rays, pollutants, climate, and thermal factors cause keratinocyte disorganization, enhanced melanogenesis, collagen dystrophy, solar elastosis, and disorder of microcirculation. The main signs of external skin aging are deep wrinkles, sagging, pigmentation, telangiectasia, skin neoplasms.
Among the local anti-aging agents, retinoids occupy a leading place, as they eliminate the main signs of skin aging. Of the entire group of retinoids, retinoic acids are the most active. However, the possibility of skin irritation limits their use. Therapeutic and cosmetic products with retinol esters (retinol palmitate) have a minimal irritating effect and can be used both for the prevention of skin aging and the elimination of its signs. Oral use of isotretinoin as an anti-aging agent is undesirable due to the many side effects and contraindications.
Development and research of a model for differential diagnosis of latent late syphilis and false-positive serological reactions on immunochips with a panel of 12 Treponema pallidum antigens
Authors: Shpilevaya Marina V. , Katunin Georgiy L. , Kubanov Alexey A.
Published: November 2021

The aim - to find the optimal attributing rules to distinguish groups of latent stages of syphilis and false positive serological tests of using multivariate discriminant analysis

Material and methods. The objects of the study were serum samples from patients with late latent (N=34) syphilis and false positive serological tests (N=31).

The samples were studied to determine IgG and IgM levels using indirect immunofluorescent reaction with immunochip containing recombinant antigens T. pallidum

Results The mathematical model allows to differentiate with a high degree of confidence patients with late latent syphilis and with false-positive serological reactions to syphilis.

Conclusions. . Multivariate discriminant analysis makes possible to create reliable mathematical models to classify patients with late latent syphilis and with false-positive serological reactions to syphilis.