bluuebunny/crossref_metadata_2025 huggingface dataset:
Alpelisib: a novel PI3K inhibitor for the treatment of breast cancer
Authors: Shao Yanting , Yao Yue , Zhang Meiyi
Published: May 2023

Breast cancer is a common malignancy that causes people to die easily, especially for women. HR-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancers occur in more than 70% of patients, who have a driver mutant kinase catalytic subunit alpha (PIK3CA) in the phosphatidylinositol 4, 5-diphosphate 3-kinase gene, resulting in impaired phosphatidylinositol 3-kinase (PI3K) and in 40% of cases, loss of cell growth. However, drug resistance remains a problem in the early stages of endocrine therapy in these patients. And a promising new approach to overcome resistance to autologous treatment in breast cancer is the inhibition of PI3K. Alpelisib is a selection PI3K inhibitor for HR-positive, HER2-negative, PIK3CA patients - with mutant breast cancer that has advanced on autologous treatment. FDA approved alpelisib in 2019 which was produced by Novartis Pharmaceuticals Corporation. It is recommended to take this drug with fulvestrant which is also an estrogen receptor antago-nist that slows the growth of breast cancer. Although alpelisib is an effective drug for the treatment of breast cancer, some adverse reactions may happen, such as stomatitis, nausea, diarrhe, dermatitis, and so on. Sometimes it also causes skin reactions, such as SIS, TEN, EM. Thus, when these serious adverse reactions happen, dosage should be reduced. As a result, some recommendations are provided for patients, and they must follow the instructions in or-der to live a more pleasant life. In this article, the working mechanism, structure, characteris-tics, clinical studies of alpelisib were reviewed and its comparison with other drugs was also provided for reference.
Research on Symptoms, Treatment and Prevention of Lumbar Muscle Strain
Authors: Wang Chidong
Published: May 2023

The rapid development of the medical industry has eased the health worries of many people. For example, uterine cancer and breast cancer are no longer as incurable as they used to be. Benign tumors basically do no harm to people's health. However, diseases such as lumbar muscle strain have not received much attention in today's medical field. Lumbar muscle strain is an injury caused by excessive fatigue. When the lumbar muscles are overused or overloaded, there will be ischemia, spasm, tension, pain, swelling and other inflammatory manifestations. That is, we feel "low back pain." This kind of illness cannot be improved very well by going to the hospital for surgery. Through this paper, we will introduce what lumbar muscle strain is, what its clinical manifestations are, and what solutions are available for different groups of people. The experimental conclusion of this paper is that there is still a lot of room for development in the field of treating lumbar muscle strain. At present, physiotherapy is the method to solve the least side effects of lumbar muscle fatigue, and the effect is relatively obvious. However, the way to avoid the disease is to pay attention to your posture, control your weight, and eat a healthy diet.
Key Substitutions in the Spike Protein of SARS-CoV-2 Delta and Omicron Variants
Authors: Zhang Tianze
Published: May 2023

The delta and omicron variants of SARS-CoV-2 (PANGO B.1.617.2. and B.1.1.529) outcompeted the earlier variations shortly after they were discovered due to their quick global dissemination. While the majority of these changes are extremely unlikely to alter the spike protein's composition or function, some might increase the virus's susceptibility to infection or make it less susceptible to vaccination, in which case they are referred to as "variants of concern" (VOC). According to previous research, the severity and transmissibility of mutant spike proteins might change if certain critical changes were present. Based on the verified mutations of spike protein, this article will discuss the specific amino acid mutations effects on the change in its transmissibility and severity. The main mechanisms affected by the mutation are the cleavage of S1 subunit1/S2 subunit2 and conformation alteration of the receptor binding domain (RBD). In conclusion, mutations in delta drastically increased its transmissibility, and mutations in omicron increased its transmissibility by becoming more stable in the environment with compromised cell fusion ability, leading to lower severity. These results emphasize the intricate relationships between alterations happened in the spike protein which influence virus stability, neutralization, and cell entering.
Interface Technologies applied for bionic prosthetic limbs
Authors: Gao Luqing
Published: May 2023

For a very long time, people have wished for a way to repair a broken limb and make it work again. The limbs are responsible for the vast majority of human movement, grasping, and other actions. If you lose them, your mental and physical health will suffer drastically. The quality of life for amputees continues to improve as new and better prosthetics are developed thanks to advancements in technology. Effective use of prostheses requires that they be at-tached to the user's natural body in some way. The development of prosthetic limbs, therefore, relies heavily on the findings of studies examining prosthetic limb interfaces. This paper pro-vides a summary of the research conducted on prosthetic interface technologies since 1985 through a method of literature review. The purpose of this paper is to provide a concise over-view of the current technologies employed in the field of prosthetic interfaces and to specu-late on the direction of future research and development in this area.
Symptoms of Bipolar Disorder and Its Distinction with Other Disorder
Authors: Fei Xiang
Published: May 2023

Bipolar disorder (BD) is a severe mental disorder and had high prevalence among the world. The overall lifetime prevalence of BP-I, BP-II and subBP are 0.6%, 0.4% and 1.4%, respectively. This article will discuss symptoms, genetic traits, hereditary patterns and treating procedure of BD. Also, differences between BD and other mental disorders and differences between sub types of bipolar disorder will be discussed in this article. For bipolar disorder patients, they will experience manic episode and depressive episode alternatively, with interphase between the two episodes. Differences in etiological agents between BD and other mental disorder lied in difference in expression of allele and environmental factors, such as childhood trauma or stressful environment. Improvement in understanding of the etiological factors and symptoms of the disease could help researchers and psychiatrists to diagnose and treat the patients.
Research on the Necessity of Wearing a Mask after Vaccination
Authors: Chen Jiasheng
Published: May 2023

In recent years, the COVID-19 pandemic has caused many people to wear masks. This article discusses the need for masks after vaccination. The research method of this study is to do some statistics and compare them to confirm the conclusions. Research shows that wearing a mask for extended periods of time after vaccination provides better protection. Therefore, it is very necessary to wear a mask after vaccination.According to the number of statistics to prove the necessity of wearing masks and vaccinations, people are urged to take relevant protective measures to minimize the spread of the virus, reduce the transmission rate, and end the era of the virus early.
Roles of Increase Fatty Acid Utilization in the Pathological Pathway of Heart Failure in Diabetes
Authors: Lyu Wenjia
Published: May 2023

This paper reviews the molecular mechanism that led diabetic patients to its major complication heart failure. While AGEs, RAAS, impaired Ca2+ handling, and ER stress also contribute to the progress of diabetic cardiomyopathy, this review emphasizes on the effect of increasing fatty acid (FA) uptake and utilization since it interconnects with other crucial causes of diabetic cardiomyopathy such as lipotoxicity, mitochondrial dysfunction, and myocardial apoptosis. The review started with the root of increasing myocardial FA metabolism, which is the overactivation of a transcription factor called peroxisome proliferator-activated receptor (PPAR). Then, the paper detailedly reviews the molecular mechanism of how increasing FA oxidation and impaired glucose oxidation leads to lipid accumulation, apoptosis, and cardiac inefficiency, which ultimately causes contractile dysfunction, left ventricular hypertrophy, and heart failure.
The Role Ipilimumab Plays in the Treatment of Melanoma
Authors: Yan Yumeng
Published: May 2023

While melanoma is not as common as other types of skin cancer among the whole dermatologic cancer category, it appears to be extremely aggressive for its high death rates. Conventional treatments like radiation therapy (RT), chemotherapy, and surgery have showed either significant side effects or limited improvement to the disease. Ipilimumab, anti-CTLA-4 antibodies, is immune checkpoint Inhibitor (ICI) approved by the FDA for being one source of treatment in the advanced melanoma in 2011 as an immunotherapeutic approach. Anti-CTLA-4 is authorized for usage as monotherapy treatment for advanced metastatic melanoma. it licensed as combination treatment for melanoma. The new study shown that the ipilimumab combined with pembrolizumab may be feasible in treating more cancerous diseases. For individuals that suffer from advanced malignant melanoma, ipilimumab decrease the overall death rates in randomized trials. The combined approach of anti-PD-1 and anti-CTLA-4 antibodies has shown feasibility.
How Food Causes Obesity
Authors: Shen Shiqi
Published: May 2023

One of the biggest threats to public health is obesity, which has developed into a concern. Obesity has been identified as an epidemic that affects people of all ages, genders, and ethnicity and requires immediate control and governance. Children and teenagers should be particularly mindful while eating ultra-processed foods. The implications of micronutrient insufficiency or the links between them and obesity are examined in this review of the literature. Findings from the research of university graduates in Spain, Brazilian civil officials, and UK Biobank show a substantial dose-response relationship between obesity and increased intake of ultra-processed meals. Additional literature review indicates the prevalence of obesity owing to its oro-sensory characteristics, satiety levels, and nutritional content.
Basic Concepts, Hypotheses and Drug Development of Alzheimer's Disease
Authors: Zhang Jinhe
Published: May 2023

Alzheimer's disease (AD) is a neurodegenerative disease that involves complicated pathogenesis and etiology that not entirely defined. As the most common form of dementia, AD is irreversibly progressive and aggravates, causing a great burden to global community. Meanwhile, the number of AD patients is growing annually with the global population aging. Unfortunately, there is currently no cure for the disease and the need for effective treatments of AD is urgent. Drug research and development for AD is a long-term and complicated process, which requires a deep understanding of the mechanisms of AD. At present, anti-Tau protein drugs as well as anti-inflammatory drugs are hot research topics. However, the clinical application of drugs still remains to improve various symptoms related to AD. This paper describes the basic concepts of pathology and gives an overview of the pathogenesis theories of AD, which include A hypothesis, Tau protein hyperphosphorylation theory, Cholinergic hypothesis and Inflammatory response. The final onset of AD is jointly caused by multiple mechanisms rather than a single one. In the paper, we summarizes the treatment strategies of AD and explores the status of drug development. This paper will help with understanding the causes of AD and provide insights into drug research and development for AD.
HPV Relevant Diseases and Vaccines, Analysis of Willingness to Vaccinate in Chinese Population and the Significance of Male Vaccination
Authors: Li Yuting
Published: May 2023

As a virus that commonly infects various populations, HPV has many types and can lead to many diseases and even malignant tumors. In this paper, the author mainly introduces HPV typing, the diseases that will cause it, and the current situation of HPV preventive vaccines, including the mechanism and types of preventive vaccines, as well as the willingness to vaccinate specific groups in some areas of China. At the end of this paper, the importance and necessity of HPV preventive vaccination for men are introduced. This paper can provide some help for future scholars in the improvement and innovation of HPV preventive vaccines, and provide some ideas and help in the direction of vaccination for male groups.
In use of Olaparib for ovarian cancer: understanding from pathogenesis, target corroboration, discovering process and treatment techanism
Authors: Wang Wenyuan , Yan Yuheng
Published: May 2023

The second most prevalent gynecologic cancer, ovarian cancer has a poor prognosis, is difficult to diagnose, and has a high mortality. EOC (epithelial ovarian cancer) is the most common subtype. PARP inhibitor has so far been approved by FDA, and used for target therapy of epithelial ovarian cancer worldwide. This article based on lots of literature research, reviews studies of ovarian cancer pathogenesis, target corroboration, Olaparib discovering process and treatment mechanism. Somatic sequence mutation occupies a prominent position in the pathogenesis of ovarian cancer. Type ovarian cancer behave PIK3CA KRAS, BRAF, PTEN, and CTNNB1 sequence mutation. Type ovarian cancers exhibit TP53 and BRCA1/2 sequence mutation. Angiogenesis, TP53, and PARP are studies in target therapy of ovarian cancer. PARP is regarded as ideal target, Olaparib is the first PARP inhibitors. Preventing PARP works in DNA damage repairing in BRCA mutation ovarian cancer cells causing cell death preferentially are confirmed as the therapeutic mechanism of Olaparib (PARP inhibitor), in therapy of ovarian cancer.
Application of Probiotics and Metazoans in Cosmetics
Authors: Qi Hongxiao
Published: May 2023

Probiotics are living microorganisms that when administered in appropriate quantities bring health benefits to the host. Probiotics products have been developed in the form of dairy products, dietary supplements, fermentation and enzyme preparations or other biological agents, and the global probiotics industry is growing at a rate of 15% to 20% per year. The clinical application of probiotics is becoming more and more extensive, especially in bacteriostasis, treatment of intestinal diseases, neonatal diseases and immune diseases, as well as in lowering blood pressure, lowering blood lipids, anti-aging, anti-tumor and central nervous system diseases. Metagenin refers to the bioactive compounds beneficial to health produced in the fermentation process of probiotics. Metagenin has anti-inflammatory, antibacterial, immune regulation, antioxidant, anti-obesity, anti-hypertension, hypidemia, liver protection, promoting wound healing and other biological activities, which has broad prospects in the development of new health functional food. This topic will be used for the method of investigation and demonstration to study the research status and future development of probiotics and metagenics cosmetics, as well as the safety evaluation of cosmetics components and human body. The main research direction is on lactic acid bacteria and bacillus.
Gene and peptide in the treatment of chlamydia trachomatis infections: beginning of an era?
Authors: Qin Jiangrong
Published: May 2023

Chlamydia trachomatis leads to the most common sexually transmitted infection (STI) worldwide, resulting in short-term and long-term health issues. The treatments for chlamydia trachomatis infection are often a hot research direction. The efficiency of antibiotics, the conventional therapy for chlamydia trachomatis infection, is decreasing gradually because of resistance, especially azithromycin. Thus, it is necessary to find new therapies to treat chlamydia trachomatis infection with higher specificity and effectiveness. Among all the trials, gene and peptide therapy stand out. As for gene therapy, IRF5 and IL-10RA are related to macrophage-chlamydia interactions. Their roles are vital in order to cure chlamydia trachomatis infection. With regard to peptide therapy, pep-1, LL-37, and melittin showed outstanding abilities in inhibiting the growth of chlamydia trachomatis. However, multiple challenges for the development of these therapies remained. Deep researches are required to address these problems in order to put these treatments into clinical use. This review summarizes the conventional treatments, and introduces gene therapy and peptide therapy for chlamydia trachomatis infection.
Predicting COVID-19 Induced Mortality Utilizing Vaccination Status Data
Authors: Chen Xiaoxuan , Tang Zhiqi
Published: May 2023

COVID-19 is a prevalent pandemic that has caused of millions of mortalities. While medical and statistical research have proven the effectiveness of COVID vaccines to reduce mortality rate in specific areas. This study aims to explore the quantitative effect of vaccine in preventing in the global level. Mortality and vaccine data was acquired from Kaggle, which summarized related data from various sources. Multiple linear regression, quasi-Poisson regression, LASSO regression, and random forest are applied to the model to analyze and predict the effect of vaccine on mortality. The adjusted R square value of these four models is 0.6670, 0.6863, 0.4901, and 0.7152 respectively. The residual boxplots of all four models show that LASSO model sometimes make extremely inaccurate predictions, and the random forest model is the most accurate model, which matches the comparison result of the adjusted R square values. Therefore, the random forest model can be potentially used to predict future COVID-related deaths based on vaccine-related data.
Clinical status, drug resistance, and countermeasures of CAR-T cell cancer immunotherapy
Authors: He Runlong
Published: May 2023

The field of adoptive immune cell therapy, known as CAR-T cells (chimeric antigen receptor-modified T-cells), has advanced significantly in recent years. However, the drug resistance of CAR-T therapy limits the further development of this technology, and a large proportion of tumor patients have drug resistance or cancer recurrence. Immune evasion due to drug resistance may be caused by CAR-T cell dysfunction, the effects of the tumor microenvironment, or drug-resistant tumor cells. The clinical status of CAR-T is reviewed here, along with the intrinsic mechanisms by which tumor cells resist CAR-T therapy and potential development options to address CAR-T resistance..
Effects of Polyunsaturated Fatty Acids on Human Health Through Intestinal Microbiota
Authors: Zhang Ruitong , Lyu Zhuo
Published: May 2023

Unsaturated fatty acids act a necessary part in the intestinal health of the host microbiota environment and immune ability by being transformed by intestinal microorganisms. Polyunsaturated fatty acids (PUFAs) are very important to the host body, also they influence many physiological activities of the body. The amount of polyunsaturated fatty acids synthesized by the human body cannot meet the daily needs of the human body, and it is necessary to obtain some essential fatty acids (EFA) from food. At the same time, some intestinal microorganisms can also synthesize and convert polyunsaturated fatty acids, which contribute to the regulation and control of host immunity. In addition, PUFAs are also beneficial to humans. They are critical in sustaining a healthy and stable gut microbiota environment and regulating and controlling host immunity. This paper summarized the conversion mechanism and effect of intestinal microbiota on polyunsaturated fatty acids, discussed whether polyunsaturated fatty acids can regulate human diseases and microbiota as health products, and determined the regulatory mechanism of polyunsaturated fatty acids.
The Impact of Environment Situation on Fireflies and the Contribution of Fireflies on Environment Situation
Authors: Shen Muyao , Qing Zijun , Lin Siyu
Published: May 2023

Firefly is an adorable insect which is often seen in our daily life as virtual characters or mascots due to its beautiful appearance. It is famous for its glowing abdomen. It can be colorful but mostly yellow and green. The biological light is rare which attracts lots of scholars and artists to study. However, after taking research on this specie, people start to ignore it. With the technology developing and land extension, they are suffering from land losing and different kind of pollution. There are countable studies on firefly protecting that lead the population of this cute creature decline steeply. The topic of this paper is about the factors which influence a lot on the population of firefly. There concentrates information from some papers related to firefly, environment pollution and bioindicator. Wishfully, this paper will be helpful to those who want to protect fireflies and those who can explore the application of fireflies. After researching, the results are about the impact of environment situation on fireflies and the contribution of fireflies on environment situation. Firefly is threatened by three aspects which are land loss, light pollution and water pollution. Land loss is due to the commercial district and residential district building of urbanization. Light pollution will disturb fireflies to find their companion and mate. Water pollution and land pollution such as insecticide will kill firefly larvae and adults directly in chemical ways. Those above are about how people gradually pushing fireflies to distinct. Its not fair of the way people treat wild fireflies. They have a lot of contribution down for people. They have controlled the number of ampullaria gigas which is a horribly threatening invasive species that confuses people for long. It is also a bioindicator which can test the level of light pollution with a relatively low cost. The biological fluorescence is pretty in the night. It has enlightened quite a few literature and art composers to create many excellent works. It is used to educate children and to witness love when wedding. Thus, the value of fireflies can be seen from this paper and how significant it is to protect wild fireflies.
Development of Provenge for Prostate Carcinoma Therapy
Authors: Chen Lixin
Published: May 2023

Provenge, as an autologous cell immunotherapy agent, was originally used to stimulate the immune cells and immunologic factors to destroy prostate cancinoma cells. For patients with hormone resistant metastatic ovarian cancer, when there are no clinical symptoms, compared to the placebo arm, the drug arm can effectively extend the median survival period of four point one months. During the three years of treatment, more than 50% of patients in the immunotherapy arm survived, and more than 50% of patients in the control group survived (31.7% vs 21.7%). Provenge, targeted to release prostate acid phosphatase, utilizes the patient's immune cells to detect and eliminate tumor cells. At the moment, there are not useful therapeutic strategies for asymptomatic patients without docetaxel and other chemical drugs treatment. The direct strategy to increase the effectiveness of Provenge is to promote more effective clinical benefits. Although the preclinical analysis and clinical efficacy of Provenge have been summarized, the clinical efficacy of enhancing efficacy needs to be reconsidered
Integrated Effects of The Amygdale, Oxytocin, and Vasopressin on Mammalian Social Behaviors
Authors: Bai Tiantian
Published: May 2023

Mammalian social behavior has long been a popular topic in the field of social interaction and cognition, providing insights into the structure formation of human society and the evolution of mammalian behaviors. The importance of the amygdala, oxytocin, and vasopressin in the mediation of sociality has been proved by many previous studies. However, the neurobiological interactions and integrated effects on behavioral regulation are relatively ignored. This review discusses these three determining factors, emphasizing the dissociable interaction at both the biological and behavioral levels. Two main ideas are presented in this review: neuropathways that directly connect oxytocin and vasopressin with the amygdala are unspecified; the mutual relationship between alienate behaviors and prosocial behaviors could be more complicated than expected. Although the influence of oxytocin and vasopressin on the amygdala has been proved by many previous studies, the specific areas and neuropathways that respond to the expression and activation of these two neuropeptides are not distinguished clearly. With more in-depth studies, the previously believed aggression behaviors that drive groups apart could also contribute to the harmony between individuals to some extent.
Analysis of risk factors of postpartum depression
Authors: Cao Shengfei , Yan Taowenxuan , Yang Jikai
Published: May 2023

With the continuous progress of science and technology, people's survival needs are growing, and the pressure is also growing. These pressures are also a huge threat to the mothers who have just given birth. Postpartum depression is a common non obstetric complication, which not only affects the physical and mental health of pregnant women, but also affects the relationship between mother and baby and the healthy growth of infants, and may even affect the whole family, such as marital disharmony. The occurrence of postpartum depression is the result of multiple factors. The neuroendocrine disorder caused by hormone changes is the pathological basis of the occurrence of postpartum depression. The postpartum depression is also mainly related to the psychological changes caused by pregnancy and childbirth. At the same time, social factors or social support are also risk factors of the disease. Early identification of high-risk factors, targeted management and intervention are carried out in each stage before, during and after childbirth, in order to better prevent and cure the disease.
Development and Prospect of Gene Editing Technology
Authors: Gao Kai , Hu Haomin , Li Siyu
Published: May 2023

Gene editing technology, as an important technology in the field of science, can accurately and stably modify the genome sequence, bringing revolutionary changes to various fields of life sciences, so it has attracted wide attention from researchers in various countries. This article makes a brief introduction to ZFN and TALEN technology, and at the same time makes a detailed introduction to CRISPR/Cas9 technology, focusing on the limitations, application, and development of CRISPR/Cas9 system. This research found that the CRISPR/Cas9 system and its related technologies are going deep into various fields of life sciences and have achieved remarkable results, providing more ideas and possibilities for human disease treatment, crop gene control and other fields.
Advances in Gene Silencing Technology
Authors: Lin Sitao , Zhao Danqi
Published: May 2023

Gene silencing is an important means of regulating gene expression in an organism, and this technique can reduce or block the expression level of a target gene. There are many types of gene silencing techniques, among which the more widely used are CRISPR/Cas9, TALEN, RNAi and so on. In recent years, with the gradual improvement and popularization of biotechnology, gene silencing techniques are slowly becoming known and applied in many fields such as gene research, disease treatment and breeding of new plant varieties. However, not all gene silencing can achieve the desired effect, and there are many reasons affecting the outcome of gene silencing. The target gene is not the only gene that determines the phenotype and there is no significant effect after knocking out the target gene. The technique also has a certain off-target rate, which can also lead to operational failure. This paper describes the principles and applications of three gene silencing techniques and compares the advantages and disadvantages of the three gene silencing techniques in order to select the most suitable gene silencing method from multiple perspectives. The current problems of CRISPR/Cas9 technology are summarized to provide certain ideas for the future development and research of CRISPR/Cas9 technology
Using Mathematical Modeling and Neuron Network to Predict the Dynamics of COVID-19 in China
Authors: Ruan Qinchen
Published: May 2023

The COVID-19 pandemic spreading from Wuhan in 2019 had a severe continuous impact globally. Even now when several vaccinations were approved by WHO and accepted widely, there are still millions of new confirmed cases daily. To provide insights for governments to make prompt and effective response with the smallest social and economic cost, numerous studies have proposed to predict COVID-19 development trend, in which mathematical modeling, such as SEIR, and neuron networks, such as LSTM, were utilized and modified widely. Among the reviewed papers, population migrations and quarantine policies were popularly considered as influential factors, while nature factors were rarely mentioned. The construction focuses of SEIR, and LSTM were parameter selection and dynamics, and solving overfitting from the data shortage and over-complicated structure respectively. The expansion of applicable environments and increase of prediction accuracy still seems to be necessary. Though this review is limited to the studies based on Chinese datasets, research from other countries may benefit from the analysis strategy
The Impact of CRISPR and Cas9 on AIDS
Authors: Xiao Peini
Published: May 2023

AIDS is a chronic infectious disease caused by the human immunodeficiency virus (HIV), and the current treatment for the disease is a combination of highly effective antiretroviral therapy, consisting of a combination of at least three of these drugs to combat HIV infection. However, this therapy only inhibits HIV replication, but does not completely eliminate the virus. Once antiretroviral treatment is interrupted, the patient's disease is prone to relapse. Therefore we need gene editing, which is the process of modifying, adding, deleting and replacing information in the body's DNA in order to modify diseases caused by genetic mutations, which can only be controlled by drugs. It is hoped that in the near future, gene editing technology will revolutionise the treatment of cancer and genetic diseases, thanks to the work of scientists.
Prognostic and Diagnostic Value of Biomarkers in Gastric Cancer
Authors: Jiang Jingyu
Published: May 2023

The fifth most prevalent cancer in the world is gastric cancer, which is aggressive illness with a low 5-year survival rate. Even though stomach cancer is becoming less frequent, patients still have a poor prognosis. Thus, early discovery using relevant screening methods, selection of an acceptable treatment strategy, and good monitoring are critical to reducing gastric cancer mortality. Biomarker identification based on clinical data and extensive genomic analysis might enhance diagnosis, prognosis, recurrence prediction, and therapy response. These biomarkers can also enable more specialized treatment strategies. This study provided an overview of the present state and methods in gastric cancer biomarkers, which may be applied for accurate treatment approach prediction, early diagnosis, and future perspectives.
A Review on the Ethical Issues in Neurotechnology
Authors: Wu Yang
Published: May 2023

Neurotechnology is rapidly evolving and there have been great advances in medical treatment, including some neurology and psychiatry disorders. Many people have been given new lifesaving treatments which help relieve their suffering. As the capabilities and applications of neurological devices have evolved, attention has been drawn to potential ethical challenges related to agency, identity, privacy, equality, regulation, and justice. This paper reviews and summarizes the current exploration of the ethical issues in neurotechnology, especially from the aspects of privacy and identity. It assesses the key methodological and ethical challenges associated with neurotechnology for today. In particular, it suggests what safeguards should be implemented in the field to reduce the concern about ethical issues.
RELATIONSHIP BETWEEN CADRE PARTICIPATION WITH POSYANDU ACTIVITIES IN DALIG RAYA VILLAGE SIMALUNGUN DISTRICT
Authors: Yunardi
Published: May 2023

The problem in this study is the relationship between cadre participation in posyandu activities in Dalig Raya Village, Raya District, Simalungun Regency. This study aims to determine the relationship between cadre participation in posyandu activities in Dalig Raya Village, Raya District, Simalungun Regency. This type of research is an analytic survey research with a cross sectional approach. The population in this study were all posyandu cadres in Dalig Raya Village, Raya District, Simalungun Regency with a total of 20 cadres. The samples taken were 19 people obtained using a random sampling technique using the Krejcie and Morgan tables. The instruments used in this study were: 1) questionnaire and 2) Observation sheets for the average coverage of D/S. The data obtained in the study were processed using the Chi Square statistical test with a 0.05. The results showed that the p values ​​of the several factors studied were as follows: 1) Knowledge of cadres about posyandu (p value -0.037); 2) The length of time the cadre has worked (p value=0.272); 3) Working hours of cadres (p value-0.249); 4) Provision of incentives (p value = 0.037), 5) Number of cadres (p value 0.530); 6) Availability of tools and materials (p value-0.574); 7) Selection (p value 0.177); 8) Development of cadres (p value=0.530); 9) Frequency of cadre meetings (p value 0.035). The results of the research and discussion concluded that there was a significant relationship between knowledge, incentives and meetings with the participation of cadres in posyandu activities in Dalig Raya Village, Simalungun Regency.
THE RELATIONSHIP BETWEEN WORK FATIGUE AND JOB SATISFACTION WITH THE WORK PRODUCTIVITY OF NURSES IN EFARINA HOSPITAL INPATIENT WARDS, 2016
Authors: Nurmala
Published: May 2023

Fatigue is a problem that needs attention. All types of work, both formal and informal, cause work fatigue. Work fatigue will reduce performance and increase work errors. Decreasing performance means decreasing work productivity. Job satisfaction is also an important target in human resource management because it directly or indirectly affects the work productivity of employees in an organization or company. analytic with a cross-sectional design to analyze the relationship between work fatigue and type of research. Tengku Mansyur Tanjungbalai Measurement of work fatigue, job satisfaction and work productivity respectively using a questionnaire. Work fatigue uses KAUPK2, job satisfaction uses a job satisfaction questionnaire while measuring work productivity uses a work productivity questionnaire. The results showed that there were 28 nurses who were tired (56.6%), the work productivity of nurses who were not suitable were 24 people (51.1%) and there were 4 people who were suitable (7.7%). There were 19 nurses (40.4%) who were not tired, 8 nurses (17.0%) who were not fit for work, and 11 nurses (23.4%) who were fit. There were 25 nurses (53.2%) who were dissatisfied, 25 nurses (53.2%) who were suitable for work productivity and none (0%) did not have suitable nurse productivity. There are 22 nurses who are satisfied (46.8%), the work productivity of nurses who are not suitable there are 7 people (14, 9%) and the work productivity of nurses who did not fit there were 15 people (31.9%). The relationship between work fatigue and job satisfaction with work productivity shows significant results (p <0.05). It is hoped that further research will be carried out on the factors that affect work productivity other than fatigue and satisfaction factors.
THE EFFECT OF USING VIDEOSCRIBE MEDIA ON STUDENT LEARNING OUTCOMES IN ISLAMIC RELIGIOUS EDUCATION SUBJECTS SMPN 2 BANDAR MASALAM SIMALUNGUN REGENCY
Authors: Jusua Barus  , Siti Nurfadillah Siregar
Published: May 2023

This type of research is quantitative research with an experimental method approach.The results of the research in this thesis, in this study, the experimental class that was taught using videoscribe media obtained an average learning outcome for Islamic Religious Education. The results of the posttest in the experimental class show that the highest score is 92 and the lowest score is 60, this indicates a significant increase compared to the pretest results in the experimental class. Whereas in the control class the highest score is 90 and the lowest score is 40, this means that there is an increase in learning outcomes but not significant in the control class. Based on the results of research that has been conducted by researchers, it can be concluded that learning using Videoscribe media can have a positive effect on educational learning outcomes Religion of Islam (PAI). This can be seen from the results of hypothesis testing at a significant level of 5% (α = 0, 05). testing the hypothesis on the posttest data of the experimental group in the output table of the paired samples test above, it is known that the Sig. (2-tailed) is 0.000 <0.05, then H0 is rejected and Ha is accepted. So it can be seen that there is an average difference between pretest and posttest learning outcomes, which means there is an effect of using videoscribe media on student learning outcomes in Islamic religious education subjects at SMP Negeri 2 Bandar Masilam.
THE INFLUENCE OF CAPITAL ADEQUACY RATIO, NET INTEREST MARGIN AND OPERATIONAL COSTS OF OPERATING REVENUE ON RETURN ON ASSET WITH LOAN TODEPOSIT RATIO AS INTERVENING VARIABLE
Authors: Puji Lestari Sri , Fitri Wahyuni Sri , Seno Affandi Wido
Published: May 2023

Research Problems: To further increase the existence of conventional banks and the trust of the Indonesian people in conventional banking services, it is necessary to improve the performance of conventional banking. The problems in this study are whether CAR, NIM, BOPO and LDR have a significant effect on ROA; Do CAR, NIM, and BOPO have a significant effect on LDR; and whether CAR, NIM and BOPO have a significant effect on ROA through LDR as an intervening variable. Research purposes: To find out how much influence CAR, NIM, BOPO and LDR have on ROA; to find out how much influence CAR, NIM, and BOPO have on LDR; and to find out how much influence CAR, NIM and BOPO have on ROA through LDR as an intervening variable. Research methods: This type of research is quantitative research with a descriptive approach. The object of this research is a commercial bank listed on the Indonesia Stock Exchange (IDX) for the 2015-2019 period. The sample in this study was 10 conventional commercial banks, which were selected based on the purposive sampling method. Data analysis technique using multiple linear regression analysis. Research Findings: Partially there is no significant effect of the CAR variable on the LDR, there is a significant negative effect of the NIM variable on the LDR; and there is a significant positive effect of BOPO on LDR; there is an insignificant negative effect of the CAR variable on ROA, there is a significant positive effect of the NIM variable on ROA, there is no significant effect of the BOPO and LDR variables on ROA. Simultaneously CAR, NIM, BOPO have a positive and significant effect on LDR and CAR, NIM, BOPO and LDR have a positive and significant effect on ROA. LDR is the intervening variable of CAR on ROA, because the number of direct effects of CAR on ROA is smaller, but LDR is not an intervening variable of NIM and BOPO on ROA because the number of direct effects of NIM and BOPO on ROA is greater than the indirect effect.
THE EFFECTIVENESS OF NUTRITION EDUCATION ON INCREASING KNOWLEDGE OF THE PROSPECTIVE BRIDE
Authors: Ningsih Tria , Husna Arfah
Published: May 2023

Stunting is a health problem that must be considered and treated early because it has a very long impact on a person's life. Aceh province is one of the provinces with the highest stunting prevalence in Indonesia, which is 37.1%. And the prevalence of stunting in West Aceh from 2015 to 2018 increased from 36.3% to 37.0%. This high prevalence is certainly a public health problem that is considered serious and must be considered, so that future generations of the nation will no longer experience stunting. Objective: to examine the effectiveness of nutrition education interventions to increase knowledge of prospective brides and grooms. Research method: the design used in this research is Quasi-Experimental with one grub pretest and posttest. The sample in this study amounted to 10 prospective brides. Samples were selected using a consecutive sampling technique. Data were analyzed using univariate and bivariate analysis (Wilcoxon test). Results: Based on the results of the bivariate test, it was found that nutrition education was effective in increasing cathin knowledge (pvalue = 0.005).
IMPACT OF ARMED CONFLICT ON TOURISM IN KASHMIR
Authors: AMIR AHMAD PEER
Published: May 2023

Many countries around the world rely heavily on tourism to support their economies. According to legend, Kashmir is known around the world as "The Paradise on Earth," because of its breath-taking beauty. Kashmir's natural beauty and rich cultural heritage are unrivalled anywhere on the planet. Every traveller fantasises about seeing Kashmir's lush green meadows, bubbling streams, and lily-covered lakes. Due to the on-going armed conflict that began in the early 1990s, this tourist destination has lost its appeal. When the tourism industry nearly collapsed in 1991, it had a significant impact on the entire state's economy, as well as individual households. Hundreds of thousands of people have died as a result of the chaos. Not only have precious lives been lost in Jammu and Kashmir, but the state's economy has also suffered a significant setback. Jammu and Kashmir has been undergoing political turmoil for the past 25 years. The tourism industry, without a doubt, has been hit the hardest by the on-going social and political unrest. The tourism industry has been hit just as hard as the allied industries, particularly Kashmiri art and craft. The present paper attempts to empirically study the impact of armed conflict on Kashmir's tourism. This supports the results, which were interpreted by the graphical representation.
Effects of Covid -19 Pandemic on Tourism in Kashmir
Authors: AHMAD DAR SHOWKAT , AHMAD LONE NASEER
Published: May 2023

Tourism is defined as leisure travel. Tourism generates jobs and promotes long-term growth, benefiting local economies. The Mughal emperor Jahangir called it "paradise on Earth." Snow-capped mountains, enchanting gardens, majestic waterfalls, apple orchards, deep gorges, and poplar, deodar, and Chinar trees are among J&K's top attractions. Tourism is big business in J&K. Tourism, the country's largest service industry, boosts the state's GDP, foreign exchange, employment, and tax revenue. Jammu and Kashmir is a popular tourist destination due to its successful development. The Covid-19 outbreak hit Kashmir just as tourist season was starting, dampening spirits. Travel and tourism have spread a novel corona virus that is highly contagious. This jeopardizes the industry's future. This paper examines how the COVID-19 lockdown has affected the tourism industry and other activities. COVID-19 is expected to have significant effects on Kashmir tourism through 2020, resulting in reduced visitor numbers and travel restrictions. That the pandemic had severe consequences for the economic development of Kashmir Valley, located in the Indian state of Kashmir. Poorer people (tourist stakeholders) were also severely harmed, the findings show. COVID-19 pandemic early effects on tourism and cost.
FACTORS RELATED TO USE OF PPE IN HEALTH WORKERS OF THE IGD UNIT AT RSUD CUT NYAK DHIEN MEULABOH
Authors: Puspita Dhani Sherly , Musnadi Jun , Eky Nursia N Lili , Maysaroh Fitri S Siti
Published: May 2023

Personal Protective Equipment (PPE) is a set of safety equipment used by workers to protect all or part of their body from the possibility of potential accidents and occupational diseases. Based on the results of a survey obtained by researchers in the field, there is data from 2020-2021, there are 52 nosocomial infection events recorded. The purpose of this study is to examine the relationship in the categories of knowledge, attitudes and compliance with the use of PPE in health workers in the IGD Unit of Cut Nyak Dhien Meulaboh Hospital. This type of research is quantitative research using cross sectional. The sample of this study used the accidental sampling method, where the researcher took a sample that happened to be found at that time amounting to 50 respondents. The results showed that there was a relationship between compliance variables (Pvalue = 0.040 and OR 0.126) with the use of PPE. However, there is no relationship of knowledge variables (Pvalue = 1.000 and OR 0.584) and attitude (Pvalue = 1.000 and OR 0.926) with the use of PPE. The conclusion of this study based on the chi-square test is that there is a relationship of compliance with the use of PPE and there is no relationship of knowledge, attitude towards the use of PPE. It is recommended to the hospital's K3 management to be able to better supervise health workers when performing medical actions to patients so that there are no health workers who do not wear PPE.
THE EFFECT OF FREE DRAWING ABILITY AND EMOTIONAL INTELLIGENCE ON THE DEVELOPMENT OF CREATIVITY FOR CHILDREN AGED 5-6 YEARS IN EARLY CHILDHOOD EDUCATION MARTABE KASIH, SILIMABAHAL VILLAGE, SIBORONGBORONG DISTRICT
Authors: Sareany Tambunan Sartika , Nahar Syamsu , Nur Nasution Wahyudin
Published: May 2023

This study aims to determine (1) free drawing activities have a significant influence on children's creativity, (2) emotional intelligence has a significant influence on children's creativity, and (3) the interaction between free drawing activities and emotional intelligence has an influence on children's creativity. The research method used in this study is a quasi-experimental method with a 2x2 factorial design. The study population was all children of PAUD Martabe Kasih, Silimabahal Village, Siborongborong District aged 5-6 years, consisting of 2 classes totaling 48 children. The sample of this study was for the control group, namely the children of group B1 which amounted to 24 children, while the experimental group, namely the children of group B2, which amounted to 24 children. The results of this study are (1) there is a positive and significant effect of free drawing activities on children's creativity, this is evident from Fcount 133.87 > Ftable 3.972. In this case, the average results of the creativity test of children who are taught with free drawing activities are higher than those of drawing activities with teacher instructions, so it can be concluded that free drawing activities are more effectively applied in learning to increase children's creativity. (2) there is a positive and significant effect of emotional intelligence on children's creativity, this is evident from Fcount 6.03 > Ftable 3.972. In this case, the average results of creativity tests for children with high emotional intelligence as a whole, both those taught with free drawing activities and drawing with teacher instructions, are higher than the average results of creativity tests for children with low emotional intelligence, and (3) there is an interaction of free drawing activities and emotional intelligence that have an influence on children's creativity, this is evident from Fcount 7.09 > Ftable 3.972. In this case, the average creativity test results of children with high emotional intelligence are better taught using free drawing activities compared to using drawing activities with teacher instructions, while children with low emotional intelligence are better taught using drawing activities with teacher instructions compared to children with low emotional intelligence. free drawing activity.