bluuebunny/crossref_metadata_2025 huggingface dataset:
Production of recombinant IGF1 and its action on neuroblastoma cells in vitro
Authors: Ishuk Sergey A. , Bogomolova Elena G. , Dobrovolskaya Olga A. , Akhmetshina Alyona O. , Krasnoshchek Daria S. , Lukovenko Anna A. , Fedorova Ekaterina A. , Klyus Alexander M. , Kolmakov Nikolay N. , Zherebtsova Julia V. , Dukhovlinov Ilya V. , Klimov Nikolai A. , Simbirtsev Andrey S.
Published: May 2019

This study aimed to develop a method for producing human recombinant insulin-like growth factor (IGF-1) based on a prokaryotic expression system and to characterize the highly purified protein.

To achieve the study’s goal, the following methods were conducted: we performed automated chemical synthesis of DNA, constructed the expression plasmid, obtained Escherichia coli cell-producers of human recombinant IGF-1, cultivated the obtained producer cells with the induction of recombinant protein synthesis by isopropyl-β-D-1-thiogalactopyranoside and lactose, and purified human recombinant IGF-1 with affinity and cation exchange chromatography.

The recombinant protein IGF-1 forms inclusion bodies during synthesis in Escherichia coli BL21 cells that contain plasmid pET28-IGF-1. Purified recombinant protein was obtained with a purity of 98% using affinity and cation exchange chromatography methods. The protein yield was 6 mg of human recombinant IGF-1 from 1 g of raw biomass. The resulting protein has the ability to protect Neuro 2a neuroblastoma cells from death caused by the deprivation of serum in the culture medium and can stimulate the differentiation of cells into neurons.

Thus, a highly purified human recombinant IGF-1 was obtained. This protein has biological activity and is suitable for preclinical studies.
Mitotic activity of epithelia of ectoand entodermal types in spontaneous and experimental teratomas of mice
Authors: Dyban Pavel A.
Published: May 2019

Spontaneous ovarian teratomas in mice (LT/Sv and LT/SvXBJ) and experimental teratomas (the result of blastocyst transplantation underneath a testicle capsule of CBAXC57 mice) are represented with derivatives of three germ layers. During the process of cytodifferentiation, the epithelium of various origins forms closed cavities (cysts), whereas in more complex morphogenetic processes, the epithelium participates in reduced organogenesis. Intestine analogs have been reported in spontaneous and experimental teratomas, but skin analogs have been shown only in experimental teratomas. The mitotic activity of lining epithelia of organ analogs differs significantly from karyokinetic figures of similar epithelia in cysts. Possible reasons for this phenomenon are discussed in this paper.
Synergy of action of antimicrobial peptides PG-1 and ChBac3.4 with antiseptics against antibiotic-resistant bacteria
Authors: Zharkova Maria Sergeyevna , Umnyakova Ekaterina S. , Afinogenova Anna G. , Afinogenov Gennady E. , Kolobov Aleksandr A. , Shamova Olga V.
Published: May 2019

We investigated the combined effects of antimicrobial peptides PG-1 and ChBac3.4 with antiseptics (sodium hypochlorite, dioxidine, prontosan, poviargolum, and etidronic acid) to identify combinations that display synergistic antimicrobial activity against antibiotic-resistant bacteria. We used the checker-board titration method to calculate fractional inhibitory concentration indices, and based on the indices the type of combined action was determined. The combined effect on the metabolic activity of bacteria was evaluated using the fluorescent marker resazurin, and the effect on the permeability of bacterial membranes for chromogenic markers was studied spectrophotometrically. The combined hemolytic activity of the combinations was investigated. Sodium hypochlorite was shown to be antagonistic with both antimicrobial peptides. With other antiseptics, combined action was characterized by additivity or synergy. Synergy was most pronounced with the preparation of highly dispersed silver poviargolum. Antiseptics accelerate the development of the antimicrobial effect of antimicrobial peptides but do not significantly affect the dynamics of the membranolytic action of antimicrobial peptides on bacterial cells. Synergy of hemolytic activity is rare. Thus, the combined use of antimicrobial peptides and antiseptics is promising for combating antibiotic-resistant bacteria and can be used to reduce the toxic effects of these compounds.
Modulating effect of recombinant lactoferrin isolated from the milk of transgenic goats on platelet aggregation activity
Authors: Shamova Ekaterina V. , Grigorieva Daria V. , Gorudko Irina V. , Sveshnikova Anastasia N.
Published: May 2019

This work showed for the first time that recombinant lactoferrin isolated from the milk of transgenic goats binds to the plasma membrane of platelets. The interaction of recombinant lactoferrin with platelets leads to the potentiation or inhibition of agonist-induced platelet aggregation depending on the type of agonist (adenosine diphosphate, thrombin, plant lectins WGA, Con A, and SNA). Using fluorescently labeled antibody CD42b it was shown by flow cytometry that recombinant lactoferrin binds to GPIb on platelets.
Clinical and electrophysiological heterogeneity of essential tremor
Authors: Muruzheva Zamira M. , Ezhov Aleksey A. , Karpenko Marina N. , Fominceva Marina A. , Klimenko Victor M. , Stolyarov Igor D.
Published: May 2019

This study aimed to identify clinical and electrophysiological signs that determine the phenotypic heterogeneity of essential tremor using a cluster analysis. Seventy-five patients with essential tremor were examined. To identify the heterogeneity of the disease, a cluster analysis was applied (k-means method). Clustering was performed according to clinical and electromyographic parameters. The heterogeneity of essential tremor is justified by amplitude characteristics, topography of tremor, duration disease, and severity of impaired of daily activity. Detecting heterogeneity in essential tremor can broaden understanding of pathogenesis disease and justify heterogeneity of the pharmacological response in patients with essential tremor.
MemoriAl plate unveiled in memory of staff of the Institute of Experimental Medicine who were victims of political repression
Authors: Zakharova Elena T. , Kolmakov Nikolay N. , Sokolov Alexey V.
Published: May 2019

MemoriAl plate unveiled in memory of staff of the Institute of Experimental Medicine who were victims of political repression
On the semantic security of cellular automata based pseudo-random permutation using results from the Luby-Rackoff construction
Authors: Faraoun Kamel Mohammed
Published: May 2019

This paper proposes a semantically secure construction of pseudo-random permutations using second-order reversible cellular automata. We show that the proposed construction is equivalent to the Luby-Rackoff model if it is built using non-uniform transition rules, and we prove that the construction is strongly secure if an adequate number of iterations is performed. Moreover, a corresponding symmetric block cipher is constructed and analysed experimentally in comparison with popular ciphers. Obtained results approve robustness and efficacy of the construction, while achieved performances overcome those of some existing block ciphers.
Dlaczego przedsiębiorstwa emitują obligacje zamienne? Analiza polskiego rynku długu zamiennego w latach 2009-2017
Authors: Kaźmierczak Damian
Published: May 2019

Celem artykułu jest identyfikacja przyczyn emisji obligacji zamiennych na polskim rynku kapitałowym. Analiza 71 emisji obligacji przeprowadzonych w latach 2009–2017 przez 38 spółek notowanych na Giełdzie Papierów Wartościowych w Warszawie wykazała, po pierwsze, że ponad połowa obligacji zamiennych została wyemitowana przez niedowartościowanie przedsiębiorstwa znajdujące się w dobrej sytuacji finansowej w celu pozyskania funduszy na realizację nowych inwestycji jako bardziej korzystna alternatywa dla zwykłej emisji akcji. Po drugie, co trzecia emisja obligacji zamiennych została przeprowadzona przez mocno zadłużone i nierentowne spółki w procesach restrukturyzacyjnych, które traktują dług hybrydowy przeważnie jako szybszy i tańszy sposób na podwyższenie kapitału własnego w stosunku do emisji akcji. Po trzecie, co piąta emisja obligacji zamiennych była przeprowadzona dla osiągnięcia korzyści podatkowych dostępnych w polskim systemie prawnym.
Identyfiacja symptomów ryzyka bankructwa przedsiębiorstwa na podstawie polskich modeli predykcji bankructwa – case study Próchnik S.A.
Authors: Kuciński Andrzej
Published: May 2019

Celem artykułu było wskazanie głównych symptomów ryzyka bankructwa spółki Próchnik, wobec której w 2018 r. ogłoszono upadłość likwidacyjną. Analizę i ocenę zagrożenia niewypłacalnością przeprowadzono na podstawie polskich modeli predykcji bankructwa. Badaniem objęto działalność przedsiębiorstwa w latach 2010–2017. Wśród najważniejszych zidentyfiowanych czynników ryzyka, które przesądziły o niewypłacalności spółki Próchnik, wskazano utratę rentowności, problemy z płynnością fiansową, malejącą efektywność zarządzania zasobami majątkowymi przedsiębiorstwa oraz niewłaściwą strukturę kapitałową.
Lublin w pracy pedagoga – zasoby miasta w działaniach edukacyjnych. Część 1. Muzea
Authors: Bieganowska-Skóra Anna
Published: May 2019

W niniejszym tekście przeanalizowano ofertę edukacyjną lubelskich muzeów. Próbowano dać odpowiedź na pytanie, czy planując oddziaływania edukacyjne, pracownicy placówek uwzględniają potrzeby młodego pokolenia oraz zalecenia dydaktyków, czy efekty ich pracy są dla dzieci i młodzieży atrakcyjne. Opis uzupełniono wykazami propozycji za-jęć oferowanych uczniom przedszkoli i szkół przez placówki wchodzące w skład Muzeum Lubelskiego w Lublinie oraz Muzeum Wsi Lubelskiej, Muzeum na Majdanku i Regionalne Muzeum Cebularza.
Nauczyciel w obliczu krzywdy dziecka
Authors: Grabowiec Anna
Published: May 2019

Spośród różnych dysfunkcji i patologii dotykających współczesne rodziny szczególnie częste i niszczące są przemoc i alkoholizm. W artykule autorka krótko przedstawia konsekwencje wychowywania się w rodzinie z problemem alkoholowym oraz doświadczania przez dziecko przemocy ze strony najbliższych. Następnie podejmuje refleksję na temat miejsca oraz roli szkoły i nauczyciela w systemie pomocy dzieciom z rodzin alkoholowych i dzieciom-ofiarom przemocy domowej.
Asertywność a radzenie sobie w sytuacjach trudnych studentów kierunków nauczycielskich z różnym poziomem samooceny
Authors: Kirenko Janusz
Published: May 2019

Za pomocą Kwestionariusza Asertywności Nauczyciela/Wychowawczego (KAN/W Teresy Zubrzyckiej-Maciąg i Janusza Kirenki), Kwestionariusza COPE (Charlesa S. Carvera, Michaela S. Scheier, Jagdisha K. Weintrauba) i Skali Samooceny (SES Marshalla Rosenberga) przebadano 244 studentów kierunków nauczycielskich, w tym 222 kobiety (90,98%) i 22 mężczyzn (9,02%). Wiek badanych mieścił się w przedziale od 21 do 46 lat, ze średnią na poziomie 25,29 lat. Byli to studenci pedagogiki, filologii angielskiej oraz pedagogiki przedszkolnej i wczesnoszkolnej z trzech uczelni: Wyższej Szkoły Ekonomii i Innowacji w Lublinie, Uniwersytetu Marii Curie-Skłodowskiej w Lublinie i Państwowej Wyższej Szkoły Zawodowej w Chełmie. Uzyskano specyficzną strukturę związków wybranych zmiennych: zależnej (gotowości do asertywności), niezależnej (radzenia sobie w sytuacjach trudnych) i moderującej (samooceny). Uwypuklano te, które mają znaczne oparcie w empirii. Zastosowana regresja wieloraka umożliwiła przyjęcie w miarę precyzyjnych charakterystyk otrzymanych związków. Pretendują one do miana autonomicznych wniosków.
Wymiar sprawiedliwości Warszawskiego Okręgu Wojskowego armii rosyjskiej na przełomie XIX i XX wieku
Authors: Kulik Mariusz
Published: May 2019

W omawianym okresie Warszawski Okręg Wojskowy obejmował tereny większości Królestwa Polskiego oraz niektórych powiatów guberni grodzieńskiej i wołyńskiej. Struktura organizacyjna okręgu była rozbudowana i analogiczna do struktury rosyjskiego Ministerstwa Wojny. Na czele okręgu stał generał-gubernator, będący jednocześnie dowódcą wojsk okręgu. Podlegały mu wojska regularne i nieregularne oraz wszelkie instytucje wojskowe znajdujące się na tym terenie, w tym wydział sądowy wraz z sądem okręgowym i sądami pułkowymi. W ich skład wchodzili oficerowie mający odpowiedni poziom wykształcenia prawniczego i praktykę zawodową. Obowiązujące przepisy regulowały zakres oraz tryb rozpatrywanych spraw sądowych. Stan etatowy zarządu sądowego Warszawskiego Okręgu Wojskowego wynosił około 90 osób, jednak stopniowo ulegał zwiększeniu. W jego składzie znajdowali się: prezes sądu, ośmiu sędziów, trzech (potem pięciu) śledczych, dziesięciu prokuratorów oraz personel pomocniczy. Skład personalny był przeważnie rosyjski, lecz spotykało się także przedstawicieli innych narodowości, w tym Polaków (Leon Iwanowski).
Zmienna amplituda stosunków państwo–Kościół katolicki w PRL w latach 80. XX w.
Authors: Łatka Rafał
Published: May 2019

Niniejsza analiza ma za zadanie przedstawić zmienną amplitudę relacji między władzami PRL a Kościołem w latach 80. XX w. Prezentuje przy pomocy najważniejszych dokumentów programowych władz, w jaki sposób kształtowały się stosunki wzajemne w kolejnych latach. Zmienność relacji między państwem a Kościołem była cechą charakterystyczną dla wspomnianej dekady i wyróżniała ją wyraźnie spośród całego okresu Polski Ludowej. Zamiarem autora jest syntetyczne opisanie relacji wzajemnych wspomnianych instytucji w dekadzie lat osiemdziesiątych przy wykorzystaniu najważniejszych materiałów źródłowych, dotąd szerzej niewykorzystywanych przez badaczy dziejów najnowszych Polski. Wniosek, jaki się nasuwa z przeprowadzonej analizy, jest dość jednoznaczny: wraz z biegiem czasu skuteczność polityki władz wobec Kościoła stawała się coraz mniejsza. Z wieloma działaniami hierarchii kościelnej i szeregowego duchowieństwa władze nie były w stanie sobie poradzić. Przyniosło to efekt w postaci stale zwiększającego się wpływu Kościoła na rzeczywistość społeczno-polityczną, z równocześnie stale spadającym autorytetem i pogarszającą się legitymizacją społeczną władz.
Wychowanie i wykształcenie króla Michała Korybuta Wiśniowieckiego (1640–1660)
Authors: Tomczak Robert T.
Published: May 2019

Celem artykułu jest analiza wychowania i wykształcenia księcia Michała Korybuta Wiśniowieckiego (1640–1660) oraz próba bliższego przyjrzenia się środowisku akademickiemu, w którym książę pobierał nauki. Dzięki analizie materiału źródłowego z polskich i czeskich zbiorów archiwalnych udało się uzupełnić stan wiedzy dotyczący młodości przyszłego elekta oraz wpływu jego wychowania na dalszą postawę społeczną i polityczną. Za główny obszar badań zostało przyjęte nieanalizowane dotychczas praskie środowisko akademickie, w którym książę przebywał cztery lata (1656–1660). Pobyt w Pradze oraz studia na Uniwersytecie praskim stanowią główną oś konstrukcyjną artykułu, prezentującego nieznane dotychczas fakty biograficzne z młodości księcia. Michał Korybut Wiśniowiecki odebrał stosunkowo typowe wykształcenie dla swojego stanu społecznego. Jednakże w wyniku licznych zaniedbań ze strony opiekunów i protektorów, przede wszystkim królowej Ludwiki Marii, edukacja książęca była uboższa w treści mające przygotować go do piastowania wysokich funkcji w państwie. Wychowanie i edukacja przyszłego króla były niedostosowane do jego charakteru oraz potencjału, a także okazały się zbyt pryncypialne.
Aluzja do rebelii Eugeniusza czy ukłon wobec aspiracji rzymskiej elity. Nowa interpretacja mowy Maeciusa Faltoniusa Nicomachusa (Hist. Aug. Tac. 6, 1–9)
Authors: Suski Robert
Published: May 2019

Jak wiemy, Historia Augusta jest jednym z najbardziej enigmatycznych literackich źródeł późnej starożytności. Manuskrypty sugerują, że Historia Augusta została napisana za panowania Dioklecjana i Konstantyna Wielkiego. Dziś jest prawie powszechnym konsensusem w historiografii, że Historia Augusta została napisana przez jednego autora, który żył wiele dekad później, niż sam sugeruje. Niektórzy współcześni badacze sądzą, że autor Historia Augusta napisał swoje dzieło w ostatniej dekadzie IV wieku. Według ich sądów mowa wygłoszona w senacie przez Maeciusa Faltoniusa Nicomachusa w żywocie Tacyta jest aluzją do uzurpacji Eugeniusa. Mowa Nicomachusa nie odpowiada wstąpieniu na tron przez Tacyta. Oczywiście Scriptor nie jest tak dbały o prawdę historyczną, jak sam sugeruje, ale nie sądzę, aby ta mowa była aluzją do uzurpacji Eugeniusza. Prawdopodobnie potomkowie Aureliana, Tacyta i Probusa, których znamy z Historia Augusta, mogą być aluzją do rzymskich senatorów, którzy doszukiwali się przodków wśród dawnych rzymskich cesarzy.
EASTERN ORTHODOX TRADITION ACCORDING TO THE STUDENTS SLAVIC CONTEST AT THE UNIVERSITY OF LUBLIN (2012–2015) / ПРАВОСЛАВНАТА ТЕМАТИК А НА УЧЕНИЧЕСКИТЕ СЛАВИСТИЧНИ КОНКУРСИ В ЛЮБЛИНСКИЯ УНИВЕРСИТЕТ (2012–2015 г.)
Authors: Rikev Kamen
Published: May 2019

Autor analizuje główne symbole i koncepcje, uważane za należące do tradycji prawosławnej, które są często wykorzystywane w prezentacjach uczniowskich podczas finałowych edycji Konkursu Slawistycznego, organizowanego corocznie od 2009 roku przez Instytut Filologii Słowiańskiej Uniwersytetu Marii Curie-Skłodowskiej w Lublinie. Analizując prezentacje z ostatnich czterech edycji Konkursu autor formułuje wniosek, że tradycje prawosławne przyciągają uwagę uczniów na Lubelszczyźnie dzięki swojej egzotyce i archaiczności, lecz utożsamiane są jedynie z rosyjskim i ukraińskim dziedzictwem kulturowym.
Nazwy bułgarskich klubów piłki nożnej – między własną tożsamością a ideologią
Authors: Maziarz Mateusz
Published: May 2019

W artykule zaproponowano autorską funkcjonalną klasyfikację nazw bułgarskich klubów piłki nożnej, występujących w trzech najwyższych ligach krajowych w sezonie 2014/15. Klasyfikacji poddano 92 nazwy klubów. W zgromadzonym materiale odzwierciedlona jest specyfika sportowej onomastyki w Bułgarii. Widoczne jest więc dziedzictwo epoki socjalizmu (1946–1989). Można również zaobserwować tendencję  do nadawania nazw klubów na cześć postaci historycznych z epoki odrodzenia narodowego z połowy XIX wieku. Nazwy klubów często nawiązują do dawnych trackich i słowiańskich nazw poszczególnych miejscowości i regionów. Rezultaty przeprowadzonej analizy wskazują na istnienie pewnych szczególnych i osobliwych prawidłowości w zakresie nadawania nazw bułgarskim klubom piłkarskim oraz świadczą o braku ciągłości historycznej tego procesu.
Antroponimia słowiańska okolic miasta Smolian
Authors: Mihaylov Miroslav
Published: May 2019

W artykule poddano analizie imiona mieszkańców okolic bułgarskiego miasta Smolian w XX wieku. Cechą specyficzną analizowanego zbioru nazw jest ich płynność, m. in. zaobserwowano proces zamiany części imion pochodzenia arabsko-tureckiego imionami o genezie słowiańskiej. Autor ustalił przyczyny popularności antroponimów słowiańskich w zakresie nominacji mieszkańców poszczególnych miejscowości tego rejonu. Okazuje się, że zmiany antroponimicznych tendencji nazwotwórczych okolic miasta Smolan można obserwować  w ciągu całego XX wieku, głównie z powodu prowadzonej w tym okresie polityki asymilacji narodowej oraz w wyniku rozmaitych inicjatyw ze strony samych polityków.
Genealogía de las “estructuras morales” de la posmodernidad: Una lectura contrapuesta en torno a la axiomática de los valores modernos
Authors: Carretero Pasín Angel Enrique
Published: May 2019

La intención de este trabajo es retrotraernos a una genealogía histórico-conceptual de la moral moderna con sus impulsores y sus detractores, para desde este punto entender el desarrollo posterior de la moralidad posmoderna. Para ello hemos tomado como referencia las formulaciones de Émile Durkheim y de Friedrich Nietzsche como dos actitudes emblemáticas, por lo que tienen de contraposición, en torno a la  configuración de los ideales de la modernidad y a las implicaciones de ellos derivadas en el dominio de la moral.
El imaginario social de la democracia en Black Mirror
Authors: Cigüela Sola Javier , Martínez Lucena Jorge
Published: May 2019

Nuestro imaginario colectivo de la democracia es eminentemente positivo y suele estar conectado a otros imaginarios como el de la transparencia, el de la tecnología y el entretenimiento, que también tendemos a imaginar vinculados positivamente entre sí. Sin embargo, la realidad de la democracia en sí misma, así como su relación con los imaginarios a los que ésta está conectada, es paradójica. En este artículo queremos mostrar cómo la teleserie inglesa Black Mirror, un producto de entretenimiento pop, permite una reflexión crítica acerca de las paradojas que ésta misma entraña. Lo haremos mostrando en qué medida los episodios 1.2 (“Fifteen Million Merits”) y 2.3. (“The Waldo Moment”) de Black Mirror permiten, mediante un análisis hermenéutico de los imaginarios sociales cristalizados en el texto audiovisual, entender, de un modo propedéutico, determinados pasajes de los pensamientos derridiano y luhmanniano, respectivamente, acerca de la democracia.
Predictors of Progressive Course of Multifocal Atherosclerosis in Patients With Myocardial Infarction
Authors: Sedykh D. Yu. , Kazantsev A. N. , Tarasov R. S. , Kashtalap V. V. , Volkov A. N. , Grachev K. I. , Shabayev A. R. , Barbarash O. L.
Published: May 2019

Purpose. Determination of clinical and instrumental predictors of progressive course of multifocal atherosclerosis (MFA) in patients one year after myocardial infarction (MI), initially having hemodynamically insignificant stenoses of carotid arteries.

Materials and methods. From database of patients with acute coronary syndrome treated in the Kemerovo Regional Clinical Cardiac Dispensary in 2009–2010 we selected for this study 141 patients with verified diagnosis of MI and hemodynamically insignificant lesions in the internal carotid artery (ICA) (stenosis up ≤ 55 %). All patients had coronary atherosclerosis verified on coronary angiography at admission because of MI. A multivariate analysis of possible predictors of the progressive course of multifocal atherosclerosis was made based on assessment of the development of cardiovascular complications (CVC) (death, MI, stroke and transient cerebral circulatory attacks [TIA]), as well as revascularizations and negative dynamics of parameters of color duplex scanning (CDS) of ICA during one year after MI. Results. One year after MI the overall incidence of CVC was 16.3 % (n=23). Structure of registered events was as follows: death from MI 7.1 % (n=10), deaths from stroke 2.1 % (n=3) and other causes 2.1 % (n=3), non-fatal MI 5.0 % (n=7), non-fatal stroke / TIA 2.1 % (n=3), carotid revascularization 2.8 % (n=4), coronary revascularization 14.9 % (n=21). CDC of ICAs was repeated in 125 patients. There were 17 (13.6 %) cases of progression of carotid atherosclerosis in the form of de novo bilateral stenoses in 14 (11.2 %) patients, stenoses in the left and right ICA 1 patient and 2 patients, respectively. The following predictors of progression of atherosclerosis of cerebral arteries were identified: family history of cardiovascular diseases (CVD),ICA stenosis ≥45 %, baseline circular atherosclerotic plaque (ASP). Predictors of high risk of stroke were family history of CVD, history of stroke,ICA stenosis ≥45 %, heterogeneous hypoechoic ASP. As predictors of lethal outcome, we identified history of MI, high functional class of angina preceding the index MI, severe coronary vascular bed involvement (SYNTAX score >23), presence of any bilateral atherosclerotic lesion in ICAs, and heterogeneous hypoechoic ASP. Assessment of the contribution of adherence to therapy in the prognosis 1 year after hospital discharge was fulfilled in 125 alive patients. It allowed to conclude that patients with progression of atherosclerosis and nonfatal CVC were characterized by insufficient adherence to standard therapy.

Conclusion. Predictors of the progressive course of multifocal atherosclerosis during one year after MI were identified in this study. It is necessary to strengthen therapeutic and preventive measures aimed at minimization of the impact of these factors in this category of patients.
Cell therapy in the multimodality treatment of a patient with dilated cardiomyopathy. A case report
Authors: Beliy S. A. , Lukashenko V. I. , Komok V. V. , Khubulava G. G.
Published: May 2019

We present a 13-years follow-up results in patient with dilated cardiomyopathy. We performed intracoronary infusion of bone marrow mononuclear fraction in patient with 4th heart failure functional class in 2005. We observed an improvement in symptoms (patient had 1st functional class of heart failure) during 10-years follow-up. In 2015 due to clinical worsening we performed 2nd and 3rd bone marrow mononuclear cells infusion with 9-month interval. We observed a signifcant improvement in symptoms, EF and LV sizes. We continue the follow-up.
Internet usage and associated factors among college students in Saudi Arabia
Authors: Akhtar Sohail , Khan Asif
Published: May 2019

Background: Internet usage has heightened exponentially globally. The Internet is a system of connected computer networks globally and millions of users are connected globally. Internet usage has increased.Methods: A cross-sectional study was to done to know the prevalence of internet usage.Results: The general prevalence of internet addiction (expressive as heavy users and very heavy users/addicts) was 42.5%.Conclusions: A high proportion of students in the college suffer from the adverse effects of Internet addiction. It is essential for psychoanalysts and psychologists to be mindful of the mental problems induced by Internet addiction.
Assessment of nutritional status among geriatric population in rural Mangaluru: a cross sectional study
Authors: D.N. Shrivathsa , Manglik Chandana G. , Saldanha Ranish Deelan , Sharma Prajna P.
Published: May 2019

Background: The percentage of elderly is growing rapidly worldwide. They are at a risk of malnutrition due to physiological, psychological, social, dietary and environmental factors.The present study was conducted to find the malnourished elderly in the community. The aims and objectives of the study were to evaluate the nutritional status of elderly using Mini Nutritional Assessment (MNA) scales; to evaluate the dietary consumption in terms of total calories and protein intake; to assess the factors associated with the malnutrition; to educate regarding nutritional importance in elderly.Methods: A community based cross-sectional study was conducted among the geriatric population (n=117) in rural Mangaluru using convenient sampling technique. After obtaining oral consent, mini nutritional assessment scale was used and socio-demography was collected. Total screening score of 14 and assessment score of 16 were summed up to get the total assessment score of 30 to determine the person’s nutritional status.Results: Majority (60.6%) of the study population was females and 39.4% were males. 53% population were Muslims and 51% belonged to nuclear family. According to MNA scale, 54 (46.7%) were at risk of malnutrition, 17 (14.5%) were suffering from malnutrition and rest 46 (39.3%) had normal nutritional status. There was a significant correlation of MNA score with BMI.Conclusions: The results suggest that MNA is a useful tool in the identification of elderly at risk of malnutrition. Due to the high prevalence of elderly who were malnourished or at the risk of malnutrition, a more detailed evaluation, regular follow up and dietary intervention is required.
Prevalence and risk factors for work related musculoskeletal disorders in flight attendants
Authors: Mulay Revati V. , Gangwal Anand , Shyam Ashok K. , Sancheti Parag K.
Published: May 2019

Background: Flight attendants are the cabin crew members working in different commercial airlines. Their main job is to ensure safety and comfort of all the passengers. They are exposed to certain ergonomic stressors like long standing, irregular working hours and working in confined spaces and thus are likely to experience work related musculoskeletal disorders. The purpose of this study was to find out the prevalence and risk factors for work related musculoskeletal disorders in flight attendants.Methods: A survey-based study was performed. Self-made questionnaire was used and was validated by 3 experts in the Physiotherapy field. Workplace stress scale was also used to determine the level of mental stress that they experience. Informed consent was taken by each flight attendant participating in the study. Questionnaire was given to flight attendants working for different airlines like Spice Jet, Air India and Jet Airways. Hard copy of the questionnaire and online forms of the questionnaire were used to complete the data collection.Results: A total of 82% flight attendants reported to have work related pain in one or more body regions. Pain was commonly reported in feet and ankle, lower back and neck. Common risk factors were lack of rest breaks, prolonged standing/long working hours, wearing heels and mental stress.Conclusions: Thus, the study shows high prevalence of work-related musculoskeletal disorders in flight attendants.
Knowledge regarding hepatitis among students of a selected government school of Trivandrum district, Kerala
Authors: . Divija , Bindhu Sukumaran Anil , Girija Nithya , Divakaran Sreelatha Deena , C. Haran Jeesha
Published: May 2019

Background: Hepatitis is inflammation of the liver which is often self-limiting, rarely leading to progressive scarring or hepatocellular carcinoma in case of chronic hepatitis. The objective of this study was to assess the knowledge regarding hepatitis among high school students of a selected government school of Trivandrum district.Methods: A cross sectional study was carried out among high school students of a selected girls only government school of Trivandrum district during October to November 2017. Permission was obtained from Institute Ethics Committee (IEC) for the study. Data was entered in MS Excel and analyzed using SPSS. Knowledge score was calculated and categorized as follows. 0 to 5– poor knowledge, 6 to 11– average knowledge, 12 to 16– very good knowledge, 17 to 21– excellent knowledge.Results: A total of 293 students participated in our study. Majority of the students had very good knowledge regarding hepatitis i.e. 64%, 10% had average knowledge, while 19% had poor knowledge. Only 7% had excellent knowledge. The mean knowledge score was 13.7 (C.I 13.44 -14.02).Conclusions: Overall, the knowledge regarding hepatitis among students was very good.
Personal hygiene practices and related skin diseases among primary school children of urban poor locality
Authors: Haradanhalli Ravish S. , Prashanth Ramya Mandya , Kumari Nitu , Siddhareddy Iswarya , D. P. Pradeepkumar , Surendran Jithin
Published: May 2019

Background: Government of India has launched ‘Swachh Bharat Swachh Vidyalaya’ initiative in 2014, with emphasis on promoting safe and hygiene practices among school children. Providing easy access to hygiene and health education regarding personal hygiene is a simple and cost effective tool for prevention and control of hygiene related health problems including skin diseases. Objectives of the study were to assess the personal hygiene practices of primary school children and to find out the skin diseases related to personal hygiene practices.Methods: The study was conducted among 12 primary schools in an urban poor locality. The availability of hygiene facilities in all the schools was noted. The hygiene practices among the children were collected using pre-designed, semi-structured proforma and clinical examination was done to find out skin diseases among them. Subsequently, all school children were given health education regarding correct hygiene practices. The data was analysed using mean, percentages and Chi-square test.Results: The study included 1404 students. Among them 40.7% took bath daily, 53.7% wore washed undergarments, uniform and socks daily, 56.5% had trimmed nails and 76.7% washed hands with soap and water before eating and after using toilet. On examination, 475 (33.8%) had skin diseases like pityriasis alba (13.2%), pediculosis capitis (12.3%), pyoderma (4.6%) and others. There was significant association between skin diseases and hygiene practices (p<0.001).Conclusions: Improper hygiene practices were associated with skin diseases. Therefore, regular social and behavioural change communication activities on hygiene practices has to be imparted for school children to prevent related skin diseases.
Study on awareness regarding snake bite hazards among people working in agriculture sector and health education about preventive and first aid measures
Authors: Guthi Visweswara Rao , Arepalli Sreedevi , Toka Sivakala , Kakamanu Lohitha Bala , Kakamanu Lakshmi Sindhura
Published: May 2019

Background: Snake bite is a common medical emergency and an occupational hazard, more so in tropical India, where farming is a major source of employment. In India alone, it has been estimated that as many as 2.8 million people are bitten by snakes, and 46 900 people die from snakebite every year. The objective of the present study is to study the awareness about hazards of snake bite and to educate about preventive and first aid measures for snake bite.Methods: This study was a community based longitudinal study conducted in 7 villages near Kurnool town. The sample size was 230. From each agriculture workers after obtaining consent pre-test was done to know their awareness regarding hazards of snake bites in agriculture fields and preventive and first aid measures in each village followed by post-test after health education.Results: In this study 230 agriculture workers were participated. Among them 108 (46.95%) were males and 122 (53.1%) were females. Most of the study population were in the age group of 31-40 years (36.9%). Using torch during nights was 68.7% it was increased significantly to 83% after health education, using foot wear was only in 30.4% and increased significantly to 100%, using stick was in 76% and increased to 100% significantly.Conclusions: The practice of using torch, wearing footwear, using stick while on field, avoid sleeping on ground in the field were significantly improved after health education. The first aid measure measures after snake bite like immobilization of bitten limb, reassure the person bitten by snake, avoid suctioning, avoiding tourniquet were also improved significantly after health education.
Lack of bundled care intervention training program will trip up rates of ventilator associated pneumonia: the contemporary trend
Authors: Kaushal Rituja , Gupta Sanjeev , Saraogi Aashish , Singh Sandhya
Published: May 2019

Background: Ventilator associated pneumonia (VAP) is the deadliest hospital acquired infection in many low resource settings of developing countries. For VAP prevention, the concept of bundle of care was defined. Evidence based resources showed it enabled great successes in VAP prevention. It has been observed in clinical practice due to insufficient compliance, there is a need to address related issues in order to define easier-to-apply procedures.Methods: It is a retrospective analytical secondary data based study. It was conducted in a tertiary care hospital of Bhopal city.Results: T value of Mann Whitney/U test was found to be statistically significant and is indicating need of “Bundle Care Intervention” training for the prevention of increase in ventilator associated pneumonia rates in any health care setting.Conclusions: Expanded bevy of options related to infect
Health profile of school dropout children in slums of the municipal corporation area of a city
Authors: Dhande Vishal Samadhan , Gadekar R. D. , Doibale M. K. , Gattani P. L. , Domple V. K. , Inamdar I. F.
Published: May 2019

Background: Though the school health services cater to health needs to an extent, the children who drop out of schools lose on this count. These children never derive the attention for the reason of school dropouts nor are they covered under any major health programs pertaining to their health problems. The objective of the study were to study health profile of the school dropout children aged 7–16 years residing in the slums of municipal corporation area of Nanded city; to study socio-demographic factors of the families of these school dropout children.Methods: It was a community based cross-sectional study carried out in urban slums of Municipal Corporation of the Nanded city in Maharashtra on the children of age group 7 to 16 who dropped out from the school. Total 455 study subjects were studied by using simple random sampling method. A pre-designed and pre-tested questionnaire was used to collect information on socio demographic variables. Thorough clinical examination of each subject was carried out.Results: The mean age of study subjects was 14.2 (±1.9 SD) years. Out of total 455 study subjects, 264 (58%) were boys and 191 (42%) were girls. 11.20% study subjects were having skin infections, 25.71% were having dental caries, 3.29% were having ear impairment, 9.89% were having visual impairment, and 1.31% was having stammering of speech.Conclusions: Anaemia, skin infections, dental caries, visual impairment were major health problems noted in the school dropped out children. Poor socioeconomic status, religion, type of family, more number of children in the family was some sociodemographic factors responsible for school dropout.
A cross sectional study on personal hygiene among rural school students in southern Rajasthan
Authors: Mangal Nitesh , Kumar L. Dilip , Varghese K. A. , Chauhan Meet
Published: May 2019

Background: The level of personal hygiene has a strong bearing on preventive capacity for many diseases and hence the assessment of its level assumes great significance. The school being a strong base for hygienic practices, the present study aimed to assess the level of personal hygiene and its associated factors as well as its effect on morbidity level of school children in a rural belt of southern Rajasthan.Methods: The cross-sectional study was conducted among 250 students studying in classes VIII to XII in 3 different schools of southern Rajasthan from November 2018 to February 2019.The data was obtained by interview method using pretested questionnaire which included socio-demographic factors, the hygienic practices and occurrence of diseases as dichotomous questions. The association of the attributes was tested through Chi-square test, correlation and regression techniques.Results: Only 22% students scored above 75% and were categorized as good practioners of personal hygiene. The age of students, parents literacy, and household income were significantly associated with personal hygiene. The common morbidities like head lice and dental caries were found gender sensitive in the study area. The negative association between disease score and personal hygiene score implied that the disease burden of children can be minimized with higher personal hygiene practices.Conclusions: Systematic efforts to sensitize school children and parents about importance of personal hygiene, improvement in parental literacy coupled with economic empowerment of rural families can help to enhance the status of personal hygiene of students and thereby drastic reduction in their disease burden.
Knowledge, attitudes and practices of adolescent school girls regarding prevention of iron deficiency anaemia
Authors: Upadrasta Venkata Prasad , Ponna Satyendra Nath , Bathina Hemalatha , S. Bharathi , Kapu Ashok Kumar Reddy , Sadasivuni Renuka , Mitaigiri Chandini
Published: May 2019

Background: Anaemia is very prevalent in adolescent girls, especially in developing countries like India. Treatment of anaemia based on the cause during adolescence decreases morbidity and mortality during early pregnancy. Despite weekly iron and folic acid supplementation programmes, the prevalence of anaemia among women and adolescent girls is still high. The objective of the study was to assess the proportion of anaemia and its determinants among adolescent school girls.Methods: An observational study was conducted in adolescent school girls of Chandragiri from January to March, 2018. Demographic data, knowledge and practices of personal hygiene were collected. Nutritional status was assessed by collecting anthropometric, body composition measurements, dietary habits and haemoglobin was estimated.Results: Of the 111 girls studied, 55.9% were found to be anaemic. Knowledge and practices of personal hygiene was lower in anaemic girls compared to non-anaemic girls. The extent of deficit of iron rich food consumption was low in both anaemic and non-anaemic girls.Conclusions: Prevalence of mild anaemia was high and iron rich foods intake was low in our study subjects. Assessment of burden of anaemia among adolescent girls is essential to address gaps in implementation of public health programs and effective intervention programs can be designed to reduce the burden of anaemia.
Prevalence of work related musculoskeletal disorders in truck drivers and its associated risk factors
Authors: Mehta Anuj , Athavale Neeraj A. , Shyam Ashok K. , Sancheti Parag K.
Published: May 2019

Background: The main purpose of the study was to find out the different joints affected in the truck drivers and the associated-risk factors for musculoskeletal pain in this population due to the paucity of literature pertaining to Indian truck drivers.Methods: A self-administered closed-ended validated questionnaire was prepared by the researcher incorporated with Nordic musculoskeletal questionnaire and numeric pain rating scale and the participants were questioned using the same questionnaire and response was recorded by the researcher.Results: This study found a prevalence rate of work-related musculoskeletal pain to be 76.92% in truck drivers and the most commonly affected joints are lower back followed by the knee, shoulder and cervical spine. The factors which are found to be responsible for work related musculoskeletal pain in truck drivers are age, years of driving, number of driving days in a week, number of driving hours in a day, rest duration, posture, stress, vibration & poor condition of roads.Conclusions: It can be concluded from the results of this study that extrinsic factors do play a significant role in the causation of work-related musculoskeletal pain in truck drivers and are a leading cause for affecting the health of truck drivers and a frequent cause of sickness absenteeism.
Utilization of AYUSH in public health care system: a review
Authors: Boovaragasamy Chithra , Narayanan Seetharaman
Published: May 2019

India is currently facing shortage of trained health workforce, especially in rural areas. WHO recommends mainstreaming of Complementary & Traditional systems of medicine as an affordable & culturally acceptable way towards achieving Universal Health Coverage (UHC). Despite the Government of India operating AYUSH clinics in PHCs for more than 10 years, we know very little about patients attending these clinics. Exploring the reasons for utilization of AYUSH care is of much value for planning to scale up the integration of AYUSH. The required information on utilization of AYUSH services were obtained through a review of the literature in PubMed databases (including MEDLINE) using the medical subject headings (MeSH) terms: ‘AYUSH’, ‘utilization’, ‘Ayurveda’, ‘Siddha’, ‘Homeopathy’, ‘morbidities’. All such studies which have focussed on profiling of patients who sought care in AYUSH were the individuals who have non–life-threatening chronic diseases or conditions. To improve AYUSH based health care services, it is imperative to understand the acceptability of AYUSH interventions among the general public for the utmost utilization of AYUSH services.
The Effects of Physical Resources on the Implementation of Inclusive Education in Public Secondary Schools – Kenya
Authors: Ireri Sr. Bibiana , Kingendo Dr madrine , Thuranira Simon
Published: May 2019

Educational frameworks and Kenyan constitutions mandate schools to adopt; design and implement programmes that support inclusive education. Despite the inclusive education policy, disability remains a major course of exclusion in public secondary schools in Kenya. The study evaluated the influence physical resources towards the implementation of inclusive education in Kenyan schools. The study employed mixed method research design which uses both qualitative and quantitative methods. Purposive sampling technique was used to select 201 respondents from 18 extra-county and county public secondary schools that had enrolled learners with physical disabilities. Quantitative data was collected using questionnaires while qualitative data was collected through interviews and focus group discussions. A t-test was used to test the significance and determine whether to reject or accept the study hypotheses. An analysis of the findings indicated significant relationships between physical resources and implementation of inclusive education. The Linear Model showed a moderate positive correlation between human resource and inclusion. The model further showed that the rate of physical resource accounted for some variation towards the implementation of inclusive education. Creating an inclusive school where physical resources are modified and restructured to respond to learner diversity is a complex process with many inter-related elements. The schools should have a collaborative approach by creating back-up partnerships with parents, the community and disability associations. There is a need mobilize all key stakeholders to modify physical resources in order to overcome barriers that hamper access and participation in the learning process
Configuring Land Rights Registration in the Agrarian Legal System (Comparative Study of Government Regulation Number 10 of 1961 with Government Regulation Number 24 of 1997)
Authors: Sunarni Sri , Asikin Zainal , Putro Widodo Dwi
Published: May 2019

Normative research concerning Configuring the Replacement of Regulations on the Registration of Land Rights by addressing the issue of ideology and Raison de Etre's rule of law gave the conclusion, that the Registration of Mastering Rights by the State should respect and recognize individual rights to land.

From the analysis and discussion that discusses, conclusions can be drawn, that is the Right to Mastery over the Land held by the Government agrees if it has the power to connect the economic sector. More details can be found: Registration of land rights cannot be agreed with political policies on land use. In the implementation of PP 10 of 1961 the government seized people's land rights, then redistributed the people who needed it as agricultural land (in addition, this program of land redistribution was communicated to the government as an asset with public reasons; it found different political attitudes when implement PP 24 of 1997, namely: by regulating the fundamentals of a new government-finance and vice versa with the Pancasila Philosophy as a principle of Efficiency-Justice Actually it was implemented at the beginning of Repelita I by enacting Law No. 1 of 1967 (Foreign Investment) A comparable increase is needed with the people's prosperity which is relatively difficult to achieve (PP 10 of 1961) which seeks to increase government original income (PAD).
Establish The Influence of Government Policies Strategies on Tourism Performance In West Pokot County
Authors: Cherop Patricia Tulel , Ombaka Beatrice , Ann Kariuki
Published: May 2019

The research focused on the influence of government policies strategies on tourism performance in west pokot county in Kenya. The study was guided objectives-policy framework, provision of infrastructure, provision of amenities and conducive taxation strategy. The theory guiding this study is consumer choice theory. The study found out government policies should have a conducive taxation strategy to attract more investors in the tourism industry. The study  recommends that the government policies should be friendly.. Areas for further research include another study be done on challenges facing domestic tourism which was not part of the study.