bluuebunny/crossref_metadata_2025 huggingface dataset:
CURCUMIN IN COMBINATION WITH TRIPLE THERAPY REGIMES AMELIORATES OXIDATIVE STRESS AND HISTOPATHOLOGIC CHANGES IN CHRONIC GASTRITIS-ASSOCIATED HELICOBACTER PYLORI INFECTION
Authors: JUDAKI Arezu , RAHMANI Asghar , FEIZI Jalil , ASADOLLAHI Khairollah , HAFEZI AHMADI Mohammad Reza
Published: May 2017

ABSTRACT BACKGROUND Helicobacter pylori (H. pylori) gastric infection is a main cause of inflammatory changes and gastric cancers. OBJECTIVE The aim of this study was finding the effects of curcumin on oxidative stress and histological changes in chronic gastritis associated with H. pylori. METHODS In a randomized clinical trial, patients were divided into two groups: a standard triple therapy group and triple therapy with curcumin group. Endoscopic and histological examinations were measured for all patients before and after 8 weeks. RESULTS Triple therapy with curcumin treatment group significantly decreased malondialdehyde markers, glutathione peroxides and increased total antioxidant capacity of the gastric mucosa at the end of study compared to baseline and triple regimen groups. In addition, the oxidative damage to DNA was significantly decreased in triple therapy with curcumin group at the end of study compared to baseline and compared to triple therapy (P<0.05 for both). Triple therapy group in combination with Curcumin significantly decreased all active, chronic and endoscopic inflammation scores of patients compared to the baseline and triple therapy group (P<0.05 for both). The eradication rate by triple therapy + curcumin was significantly increased compared to triple therapy alone (P<0.05). CONCLUSION Curcumin can be a useful supplement to improve chronic inflammation and prevention of carcinogenic changes in patients with chronic gastritis associated by H. pylori.
Corn yield, forage production and quality affected by methods of intercropping corn and Panicum maximum
Authors: Almeida Rodrigo Estevam Munhoz de , Gomes Caio Macret , Lago Bruno Cocco , Oliveira Silas Maciel de , Pierozan Junior Clovis , Favarin José Laércio
Published: May 2017

Abstract: The objective of this work was to evaluate methods of intercropping corn and Panicum spp. forages and their effects on corn yield and forage development. Two experiments with Panicum spp. were conducted, one with 'Tanzania' and other with 'Massai' in the municipality of Piracicaba, in the state of São Paulo, Brazil, in the 2012/2013 growing season. In both experiments, the treatments were: broadcast seeding of Panicum spp. at the same time of corn sowing; corn with Panicum spp. between rows; Panicum spp. sown with fertilizer; Panicum spp. sown between corn rows after corn establishment; broadcast seeding of Panicum spp. after corn establishment; and sole corn sowing. For corn, leaf nitrogen content, ear height, and grain yield were evaluated. For Panicum spp. cultivars, height, dry mass, tiller density, and leaf:stem ratio were evaluated. The intercropping establishment methods used do not affect corn growth, grain yield, and N leaf content. The seeding of both cultivars of Panicum spp. when corn plants had four expanded leaves reduces forage dry mass production and increases the leaf:stem ratio. The Panicum spp. broadcast method, performed after corn was established, does not allow appropriate establishment, with few plants in the area.
Modelagem da progressão da DBO obtida na incubação de esgoto doméstico sob diferentes temperaturas
Authors: Matos Mateus Pimentel de , Borges Alisson Carraro , Matos Antonio Teixeira de , Silva Edson Faria da , Martinez Mauro Aparecido
Published: May 2017

RESUMO Confiável quantificação da demanda bioquímica de oxigênio exercida (DBO exercida) poderá ser obtida com incubação das amostras sob temperaturas diferentes, desde que o valor da demanda bioquímica de oxigênio última (DBOU) não seja alterado nessas condições. Alguns autores têm relatado aumento no valor da DBOU com a elevação da temperatura de incubação das amostras, o que pode ser decorrente da ocorrência da nitrificação, da aclimatação diferenciada ou do mau ajuste dos modelos de progressão da demanda bioquímica carbonácea de oxigênio (DBO exercida). Neste estudo, objetivou-se avaliar o efeito da temperatura sobre a progressão da DBO exercida e o valor da DBOu em amostras de esgoto doméstico bruto, avaliando-se qual modelo melhor se ajusta aos dados obtidos. Os resultados indicaram pequena influência da temperatura de incubação das amostras nos valores da DBOU do esgoto sanitário e que os modelos de primeira e segunda ordens descreveram adequadamente a progressão da DBO exercida.
Emprego de Aspergillus niger AN 400 em reatores de bancada para remover pesticida de matriz aquosa
Authors: Freitas Luciane Mara Cardoso , Barbosa Bárbara Chaves Aguiar , Rodrigues Kelly , Marinho Glória
Published: May 2017

RESUMO Esta pesquisa propõe utilizar o fungo Aspergillus niger AN 400 no tratamento de matriz aquosa contendo metil paration por meio de reatores em batelada, sendo dividida em duas etapas. Na etapa I, foram montados reatores controle (RCs) contendo apenas metil paration em matriz aquosa; reatores contendo metil paration e suspensão de esporos de fungo (RFs); e reatores contendo metil paration, suspensão de esporos de fungo e etanol (RFEs). A cada tempo de reação (TR), um RC, um RF e um RFE eram colocados fora de operação. Os TRs estudados foram distribuídos em 30 dias. Na etapa II, operou-se um reator com biomassa imobilizada (RBI) alimentado por metil paration e etanol, efetuando-se cinco ciclos cada um com duração de uma semana. Como resultados, na Etapa I, verificou-se que o pH variou de 5 a 8, atingindo remoções finais de 61% (RF) e 89% (RFE) de demanda química de oxigênio (DQO) bruta; 67% (RF) e 52% (RFE) de nitrogênio amoniacal; 34% (RF) e 45% (RFE) de nitrato; 2% (RF) e 15% (RFE) de fósforo total. Na Etapa II, o pH variou de 3 a 8 e as médias de remoção final foram: 94% de DQO filtrada, 88% de DQO bruta, 19% de nitrogênio amoniacal, 96% de nitrato, 12% de fósforo total e metil paration de 95%, com biomassa imobilizada e 73% (95%) com biomassa dispersa. Os resultados mostraram que a utilização do fungo Aspergillus niger AN 400 pode ser uma alternativa no tratamento de água residuária contendo metil paration.
Utilização de macrófitas aquáticas de três diferentes tipos ecológicos para remoção de Escherichia coli de efluentes de criação de pacu
Authors: Assunção Argos Willian de Almeida , Gatti Junior Pedro , Almeida Renata Vilar , Gasparotto Yuri , Amaral Luiz Augusto do
Published: May 2017

RESUMO O presente trabalho avaliou a contaminação por Escherichia coli em viveiro de criação de pacu (Piaractus mesopotamicus) e sua remoção do efluente utilizando um sistema do tipo constructed wetland, contendo macrófitas aquáticas de três tipos ecológicos diferentes (Eichhornia crassipes, Ceratophyllum demersum e Typha domingensis). Durante três meses foram realizadas análises do número mais provável (NMP) de Escherichia coli na água de abastecimento do viveiro, no seu efluente e em cada etapa do tratamento (sedimentação e emprego de cada espécie de macrófita). Concluiu-se que a contaminação por E. coli na água de abastecimento e no viveiro pode alcançar o ambiente por meio do efluente. O sistema de tratamento proposto foi eficiente na remoção de E. coli da água, sendo que, após estabilização do sistema, ocorreu remoção média de 95% da contaminação. A etapa contendo E. crassipes apresentou maior remoção média, porém mostrou diminuição da eficiência a partir de 60 dias após implementação do sistema. A remoção média das etapas contendo C. demersum e T. domingensis foi prejudicada devido à presença de E. coli no solo usado como substrato durante as primeiras semanas de experimento. Contudo, com a diminuição do efeito da contaminação presente no substrato, essas duas etapas foram fundamentais para manutenção da qualidade do efluente tratado, demonstrando que o consórcio de espécies de tipos ecológicos diferentes foi vantajoso, uma vez que a qualidade da água do efluente foi mantida mesmo quando algumas etapas do tratamento diminuíram sua eficiência.
Desenvolvimento Psíquico e Elaboração Conceitual por Alunos com Deficiência Intelectual na Educação Escolar1
Authors: PADILHA Anna Maria Lunardi
Published: May 2017

RESUMO: considerando que o desenvolvimento humano é passagem do ser biológico ao ser cultural e que são as condições de existência, criadas pelos homens, ao longo da história de cada povo, que promovem o desenvolvimento das funções propriamente humanas, neste texto pretende-se dar destaque à elaboração conceitual, própria da educação escolar, pelos alunos com deficiência intelectual. O percurso da reflexão segue trazendo, primeiramente, as bases teóricas da Psicologia Histórico-Cultural para a compreensão das leis gerais que regem o desenvolvimento cultural das pessoas. Em seguida, desenvolvem-se argumentos acerca das funções psicológicas superiores ou culturais e a elaboração conceitual como condição e caminho desse desenvolvimento. Na terceira parte, apresenta-se a mediação entre os fundamentos da Psicologia Histórico-Cultural e a educação escolar realizada pela Pedagogia Histórico-Crítica. Conclui-se abordando as práticas pedagógicas e as possibilidades que se abrem para a educação das pessoas com deficiência, uma vez que, por meio delas, se dê a significação do mundo e de si, elevando e transformando, portanto, os conhecimentos cotidianos em direção à apropriação dos conceitos científicos.
Concepção do Primeiro Curso Online de Pedagogia em uma Perspectiva Bilíngue Libras-Português1
Authors: MACHADO Erica Esch , TEIXEIRA Dirceu Esdras , GALASSO Bruno José Betti
Published: May 2017

RESUMO: o presente artigo tem como objetivo contextualizar o processo de construção do primeiro curso superior online de Pedagogia Bilíngue (Libras- Português). Esta iniciativa é resultado de demanda do Governo Federal que instituiu a criação de cursos de Pedagogia na perspectiva bilíngue como parte integrante do Plano Nacional dos Direitos da Pessoa com Deficiência. Neste artigo, procuramos evidenciar o posicionamento político-pedagógico do Curso, a dinâmica entre os fundamentos da educação online colaborativa e as especificidades da educação de surdos, criando um lócus de realização capaz de potencializar as interações entre estudantes surdos e não-surdos por meio do círculo de cultura.
Pais de Crianças com Paralisia Cerebral Pouco Estressados1
Authors: CUNHA Katiane da Costa , PONTES Fernando Augusto Ramos , SILVA Simone Souza da Costa
Published: May 2017

RESUMO: a presente pesquisa objetivou identificar, com base na Bioecologia do Desenvolvimento de Bronfenbrenner, fatores de proteção e de risco nas falas de pais de crianças com paralisia cerebral considerados pouco estressados. Inicialmente, 101 pais responderam aos questionários sociodemográficos, de limitação funcional da criança e de estresse parental. Posteriormente, um grupo focal foi realizado com sete pais. Verificou-se maior frequência de relatos protetivos, principalmente relacionados à pessoa, entretanto também se observou relatos sobre o contexto e o tempo. Finalmente, verificou-se que os pais utilizaram mecanismos protetivos eficientes, que podem justificar o baixo nível de estresse encontrado.
Instrução Islâmica na Senegâmbia e práticas de Muçulmanos Africanos em Portugal: uma abordagem Atlântica (séculos XVI e XVII)
Authors: Mota Thiago Henrique
Published: May 2017

Resumo Práticas islâmicas de africanos escravizados em Portugal no século XVI são analisadas à luz da metodologia atlântica, buscando-se compreendê-las em relação às instituições muçulmanas na região dos rios Senegal e Gâmbia. Parte-se desta perspectiva para estudar culturas africanas na diáspora identificando elementos africanos em Portugal; retornando à África, são relacionados às sociedades de origem; voltando a Portugal, os dados obtidos são confrontados. As fontes da pesquisa são memoriais de viajantes europeus, cartas de jesuítas e processos inquisitoriais. Argumenta-se que as práticas islâmicas em Portugal expõem continuidades de experiências africanas, evidenciando o papel do Islã nas sociedades da Senegâmbia.
Latin America in Global History: An Historiographic Overview
Authors: Olstein Diego
Published: May 2017

Abstract World history can be arranged into three major regional divergences: the 'Greatest Divergence' starting at the end of the last Ice Age (ca. 15,000 years ago) and isolating the Old and the New Worlds from one another till 1500; the 'Great Divergence' bifurcating the paths of Europe and Afro-Asia since 1500; and the 'American Divergence' which divided the fortunes of New World societies from 1500 onwards. Accordingly, all world regions have confronted two divergences: one disassociating the fates of the Old and New Worlds, and the other within either the Old or the New World. Latin America is in the uneasy position that in both divergences it ended up on the 'losing side.' As a result, a contentious historiography of Latin America evolved from the very moment that it was incorporated into the wider world. Three basic attitudes toward the place of Latin America in global history have since emerged and developed: admiration for the major impact that the emergence on Latin America on the world scene imprinted on global history; hostility and disdain over Latin America since it entered the world scene; direct rejection of and head on confrontation in reaction the former. This paper examines each of these three attitudes in five periods: the 'long sixteenth century' (1492-1650); the 'age of crisis' (1650-1780); 'the long nineteenth century' (1780-1914); 'the short twentieth century' (1914-1991); and 'contemporary globalization' (1991 onwards).
Is similar the distribution of Chironomidae (Diptera) and Oligochaeta (Annelida, Clitellata) in a river and a lateral fluvial area?
Authors: Cesar Daniela Aparecida Silveira , Henry Raoul
Published: May 2017

Abstract Numerous factors may affect the pattern of distribution of benthic fauna in a river mouth region and, among the macroinvertebrates, Chironomidae and Oligochaeta are the most abundant groups and most tolerant to environmental changes. Aim The aim of this study was to evaluate the controlling factors of and a possible similarity between Chironomidae and Oligochaeta assemblies at two close sites, the mouth of the Guareí River into the Paranapanema River (São Paulo, Brazil) and its lateral fluvial area. Methods Fauna samples were collected every three months during one year. Water physical and chemical variables and sediment variables were also determined in the same period. Results Both assemblies presented low density variability over time in the lateral area due to sediment characteristics and environmental factors. Taxa Caladomyia, Parachironomus, Pristina sp., Pristina osborni, Bothrioneurum and Opistocysta funiculus were recorded at this site. The Guareí River presented both greater temporal and spatial variations, attributed mainly to a reduction in the water level. Greater organism abundance, especially of Chironomus and Tubificinae, was observed in the river. Conclusions Dissimilarity in temporal and spatial distributions of Chironomidae and Oligochaeta was attributed to peculiar characteristics of the two study sites, a river channel and a lateral area. Reduction in the water level over the year was the main controlling factor of Chironomidae and Oligochaeta richness and density in the river. In the lateral area, the presence and abundance of certain taxa were determined by the nature of the sediment and water physical and chemical variables.
The design and construction of the Pont Briwet Viaduct, UK
Authors: Barnes Jeremy Nigel , Gill John Christopher
Published: May 2017

Minimising maintenance requirements and whole-life costs is becoming increasingly important to clients. The new Pont Briwet combined road and rail viaduct in north Wales addresses this, as it is a fully integral structure. No movement joints were provided for the highway and no rail adjustment switches were required. At 133 m long, eliminating any movement provision posed certain design and construction challenges. This paper describes the analysis undertaken to prove movement provision was not required and describes how this influenced the arrangement and detailing. As it is set in a picturesque estuarine location in Snowdonia National Park, the client also desired a visual form for the viaduct befitting its surroundings. The construction challenges in meeting this requirement and those posed by the integral nature of the viaduct are also described.
«Constitutional Fever»? Constitutional Integration in Post-Revolutionary France, Great Britain and Germany, 1814–c.1835
Authors: Rausch Fabian
Published: May 2017

«Constitutional Fever»? Constitutional Integration in Post-Revolutionary France, Great Britain and Germany, 1814–c.1835

This article proposes a comparative perspective on the role of constitutions in European political cultures from 1814 to c.1835. Through its analysis of constitutions first as a means to legitimising post-revolutionary monarchies, and secondly as a means to integrating the divided societies in France, Great Britain as well as the German states, this article suggests two major results: 1) Constitutions were a central instrument that was imagined by post-revolutionary European societies in order to open up an «evolutionary» path to political progress and thereby finally «end» or «prevent» further revolutionary changes. 2) The major challenges to constitutional integration were posed by the emergence of competing political groups that often demanded a strengthening of certain parts of the constitutions or their further reform. The problems, which were faced by almost all political actors regarding the acceptance of these new imperatives of party politics and the different constitutional «solutions» that they had developed to meet these challenges, provide explanations for the different constitutional paths that were taken by Great Britain, the German states and France during the early 1830s. In Great Britain, a common constitutionalist language enabled a precarious understanding amongst the competing groups, whereas anti-pluralist constitutional conceptions led to constitutional instability in France and even damaged the very idea of constitutional integration in Germany thus benefitting a «unification first»-approach in the German states.
El currículum familiar: herramienta pedagógica alternativa para la educación
Authors: Salazar Andrés José
Published: May 2017

The research that here is presented is centered in the process of generation of knowledge and truths through the curriculum family, as tool pedagogical alternative for weaving encounters with it lived. In the work is taken as samples representative to three groups family of the State Sucre, specifically of the peninsula of Araya: the corner, family Ortiz; Manicuare, Pereda family; Araya, Salazar family. Through this curriculum is achieved to know its history and shows its behavior in various aspects of his live daily; among those who can point out: the preservation of the values, customs, beliefs and traditions of his native lar. Similarly, the role of the family education beyond school spaces are taken into account, and get know these living testimonies of their wisdom, warmth and authenticity; legacies left during the course of its existence, as a contribution of live or have lived. These personal aspects, each family in particular, were important for the researcher to set its position on the conceptualization of the “family resume”. The study is purely empirical and is part of the qualitative approach by applying two methodological variants: Phenomenology and the life stories; in an ethnographic study that combines observation participant and interview in depth biographical type.At work is made clear how develop perceptions of breeding, training, education, work and other categories of analysis of importance of families involved in thestudy, linked with the conditions and experiences of its transit through life.
Relaciones familiares versus aprendizaje: un análisis con niños de 5 a 6 años
Authors: Jacometo Durante Marisa Claudia , Yanagu Adriana Rossato
Published: May 2017

El contexto de la afectividad es el proceso de aprendizaje y se basa en la familia que se desarrollan los primeros hábitos, que garantiza, o no, una base sólida y segura para hacer frente a la adversidad. La investigación se enfocó en examinar si el aprendizaje de los niños puede verse comprometida por la afectividad en el entorno familiar. Específicamente: a) Identificar el entorno de la afectividad experimentan las familias; b) Entender cómo este entorno la afectividad puede poner en peligro la relación interpersonal que se construye por los niños en la etapa de la alfabetización; c) Entender cómo este entorno la afectividad puede interferir con el aprendizaje de los niños. Metodológicamente se utilizó el estudio de caso con 219 familias con niños de entre 5 y 6 años que están en la educación de la primera infancia en las escuelas públicas y privadas en el municipio de Lucas do Rio Verde - MT. El método de enfoque inductivo es el análisis cualitativo. Los datos fueron recolectados a través de un cuestionario. Los principales resultados indican que el aprendizaje de los niños puede verse comprometida por la afectividad en el entorno familiar, ya que el aprendizaje y el rendimiento escolar depende, en primer lugar, la interrelación familiar y más tarde, la relación entre el profesor y el estudiante. Se considera que la afectividad y la inteligencia son inseparables.
muSCOPE BLAST v1
Authors: Youens-Clark Ken
Published: May 2017

How to use the muSCOPE BLAST app.
New Ferrocenyl Phenol Thiophosphines
Authors: Bretosh Kataryna , Vincendeau Sandrine , Routaboul Lucie , Daran Jean-Claude , Voitenko Zoia , Manoury Eric
Published: May 2017

Two new enantiomerically pure ferrocenyl phenol-thiophosphine compounds have been efficiently synthesized by a one pot procedure from enantiomerically pure alcohol (R)-(diphenylthiophosphinoferrocenyl)methanol 1 by a fully regioselective Friedel-Crafts reaction on phenols after strong acid activation. A mechanistic proposal through O-alkylation followed by rearrangement of the formed oxonium is proposed. All compounds have been and fully characterized by NMR(1H, 31P and 13C) and High Resolution Mass Spectroscopy. The molecular structure of one of these ferrocene derivatives have been determined by X ray diffraction analysis on monocrystal.
Zalina Rolim e Helena Morley: duas escritoras-educadoras
Authors: Dal Farra Maria Lúcia
Published: May 2017

Este artigo compara duas escritoras-educadoras brasileiras – Zalina Rolim e Helena Morley – que escreveram e publicaram no final do século XIX, uma paulista e outra mineira, uma poetisa e outra narradora, ambas preocupadas com a educação infanto-juvenil e ambas revelando nas suas obras literárias, cada qual a seu modo, aspectos relevantes da burguesia brasileira à sua época e da condição feminina no seio da família burguesa.
COELHO, Alexandra Lucas. Deus-dará. Lisboa: Tinta-da-China, 2016. 568 p.
Authors: Barros Bruno Mazolini de
Published: May 2017

Resenha do romance Deus-dará, de Alexandra Lucas Coelho.
Study of maternal and fetal outcome in twin pregnancy
Authors: Singh Lata , Trivedi Kiran
Published: May 2017

Background: Multiple pregnancies are associated with an increased risk of obstetric complications as well as perinatal morbidity and mortality especially in developing countries. The present study aims to understand the maternal and perinatal outcomes of multiple and singleton pregnancies delivering at Rajendra Institute of Medical Sciences, Ranchi, India. Aim of study was to investigate the maternal and fetal outcome in twin pregnancies in Rajendra Institute of Medical Sciences (RIMS), RanchiMethods: This comparative prospective study was conducted in the department of obstetrics and gynecology, Rajendra Institute of Medical Sciences, Ranchi from the period of 1st April 2015 to 30th September 2016. Consecutive sampling was done till the sample size of 75 was reached for both twin and singleton pregnancies. It included all women admitted in antenatal ward and labor room with clinical or ultrasound diagnosis of twin pregnancy after 28 weeks of gestation.Results: The incidence of twins in this study was 1.85%. Mean maternal age was 25.25±4.5 years for twin pregnancies and 23.53 ± 3.3 for singleton pregnancies. Twins were seen more in multigravida (70.7%) as compared to primigravida (29.3%). Preterm labor (74.7%), anemia (44%) and hypertensive disorders (32%) and PPH (13.33%) were the most common complication in twin pregnancies. Significantly higher rate of LSCS were seen in twin pregnancies (32.67%) as compared to singletons 18.67%. Mean weight of first twin was 2.03±0.52kg and for second twin it was 1.98±0.51kg. There was higher incidence of moderate to severe asphyxia, IUGR and higher rate of NICU admissions in twins as compared to singletons. Perinatal mortality rate of monchrionic pregnancy was 30% and it was 10.2% for dichorionic pregnancy which shows a significant association of perinatal mortality rate and chorionicity.Conclusions: Good antenatal care, with increased rest and nutritional supplementation, early detection of fetal and maternal complications together with thorough intranatal and postnatal vigilance, can lower both maternal and fetal dangers.
Epithelial Mesenchymal Transition Network-Based Feature Engineering in Lung Adenocarcinoma Prognosis Prediction Using Multiple Omic Data
Authors: Shao Borong , Cannistraci Carlo Vittorio , Conrad Tim OF.
Published: May 2017

Epithelial mesenchymal transition (EMT) process has been shown as highly relevant to cancer prognosis. However, although different biological network-based biomarker identification methods have been proposed to predict cancer prognosis, EMT network has not been directly used for this purpose. In this study, we constructed an EMT regulatory network consisting of 87 molecules and tried to select features that are useful for prognosis prediction in Lung Adenocarcinoma (LUAD). To incorporate multiple molecular profiles, we obtained four types of molecular data including mRNA-Seq, copy number alteration (CNA), DNA methylation, and miRNA-Seq data from The Cancer Genome Atlas. The data were mapped to the EMT network in three alternative ways: mRNA-Seq and miRNA-Seq, DNA methylation, and CNA and miRNA-Seq. Each mapping was employed to extract five different sets of features using discretization and network-based biomarker identification methods. Each feature set was then used to predict prognosis with SVM and logistic regression classifiers. We measured the prediction accuracy with AUC and AUPR values using 10 times 10-fold cross validation. For a more comprehensive evaluation, we also measured the prediction accuracies of clinical features, EMT plus clinical features, randomly picked 87 molecules from each data mapping, and using all molecules from each data type. Counter-intuitively, EMT features do not always outperform randomly selected features and the prediction accuracies of the five feature sets are mostly not significantly different. Clinical features are shown to give the highest prediction accuracies. In addition, the prediction accuracies of both EMT features and random features are comparable as using all features (more than 17,000) from each data type.
Reducing the Search Space in Literature-Based Discovery by Exploring Outlier Documents: a Case Study in Finding Links Between Gut Microbiome and Alzheimer’s Disease
Authors: Cestnik Bojan , Fabbretti Elsa , Gubiani Donatella , Urbančič Tanja , Lavrač Nada
Published: May 2017

Literature-based discovery tools have been often used to overcome the problem of fragmentation of science and to assist researchers in their process of cross-domain knowledge discovery. In this paper we propose a methodology for cross-domain literature-based discovery that focuses on outlier documents to reduce the search space of potential cross-domain links and to improve search efficiency. In a previous study, literature mining tools OntoGen for document clustering and CrossBee for cross-domain bridging term exploration were combined to search for hidden relations in scientific papers from two different domains of interest, where the utility of the approach was demonstrated in a study involving PubMed papers about Alzheimer’s disease and gut microbiome. This paper extends the approach by proposing a methodology, implemented as a repeatable workflow in a web-based text mining platform TextFlows, which enables easy access and execution of the methodology for the interested researcher.
Influence of rs2228570 on Transcriptional Activation by the Vitamin D Receptor in Human Gingival Fibroblasts and Periodontal Ligament Cells
Authors: Liu Kaining , Han Bing , Meng Huanxin , Hou Jianxia
Published: May 2017

Background: rs2228570 is the only known single nucleotide polymorphism of the vitamin D receptor (VDR) that alters the protein structure. VDRs can be distinguished using the restriction endonuclease FokI and accordingly divided into three genotypes: FF, Ff, and ff. Influence of rs2228570 on transcriptional activation by VDRs in human gingival fibroblasts (hGFs) and periodontal ligament cells (hPDLCs) is investigated in this study.

Methods: From 15 donors, hGFs and hPDLCs were cultured, genomic DNA was extracted, and genotypes were determined using the polymerase chain reaction (PCR)‐restriction fragment length polymorphism method. Cells were stimulated with calcitriol with or without VDR antagonist ZK159222 or osteogenic induction. Alkaline phosphatase, osteocalcin, and VDR messenger RNA (mRNA) expression were detected using real‐time PCR. Alkaline phosphatase and osteocalcin protein expression were detected by enzyme activity assays with p‐nitrophenyl phosphate substrate and enzyme‐linked immunosorbent assay, respectively.

Results: Among the 15 donor cell cultures, the number of FF, ff, and Ff genotypes were 5, 3, and 7, respectively. There were no significant differences in expression of alkaline phosphatase or osteocalcin among the three genotypes in hGFs. However, after stimulation with calcitriol, alkaline phosphatase and osteocalcin mRNA levels in FF‐hPDLCs were significantly higher than in other hPDLCs genotypes, as was osteocalcin protein expression. Furthermore, when ZK159222 was included, this difference disappeared, and when osteogenic induction was performed, alkaline phosphatase and osteocalcin mRNA and protein levels were higher in FF‐hPDLCs than in the other hPDLCs genotypes.

Conclusion: The FF‐VDR genotype is associated with the most remarkable upregulation of alkaline phosphatase and osteocalcin in hPDLCs.
Microbiota Analysis of Biofilms on Experimental Abutments Mimicking Dental Implants: An In Vivo Model
Authors: Cortés‐Acha Berta , Figueiredo Rui , Seminago Ramón , Roig Francisco J. , Llorens Carlos , Valmaseda‐Castellón Eduard
Published: May 2017

Background: The microbiota colonizing dental implants has been said to be similar to the microbiome surrounding teeth. In the absence of inflammation, a biofilm with pathologic bacteria can cover implant surfaces exposed to the oral cavity, for example, due to a remodeling process. The aim of the present study is to identify microbiota surrounding exposed dental implants in patients with and without a history of periodontitis through a deep‐sequencing approach.

Methods: An experimental abutment with the same surface and structure as a commercially available dental implant was used. Bacterial DNA was isolated, and the 16S ribosomal RNA gene was amplified and sequenced. Multiplexed tag‐encoded sequencing of DNA from the samples was performed, and the reads were processed by metagenomic rapid annotation.

Results: A wide variety of bacteria, 96 species, were identified. The most frequently found bacteria were Fusobacterium nucleatum and Prevotella denticola. Some species generally associated with periodontitis were found to a greater extent in patients without a history of periodontitis. Some bacteria that have never been described as part of the oral microbiome were identified in the present sample.

Conclusions: Analysis of data suggests that the bacteria surrounding exposed dental implants form a diverse microbiome regardless of the periodontal profile of patients. Further research is needed to clarify the role of these microorganisms in the oral environment.
LOKOV NOVI PUT IDEJA
Authors: POPOVIĆ UNA
Published: May 2017

Filozofija Džona Loka u ovom radu razmatra se iz perspektive njegovog razumevanja ideja i opažanja, sa ciljem da se rekonstruiše Lokov metod mišljenja. Lokov metod, novi put ideja, razume se kao bitno vezan za njegovo empirističko opredeljenje, i kao konstitutivan za celokupan projekat njegove filozofije. Centralne analize u radu posvećene su razmatranju veze opažaja, ideje i njima opredeljenog filozofskog načina mišljenja.
ODREĐENJE OBJEKTIVNOG DUHA KROZ ODNOS PREMA SUBJEKTIVNOM I APSOLUTNOM DUHU
Authors: JOVANČEVIĆ DEJAN
Published: May 2017

Na negativni podsticaj sve prisutnije tendencije da se filozofija iskorenjuje, odvaja od svoje najbolje tradicije, nastoji se u ovom članku odrediti pojam nad kojim postoji takva vrsta sumnje da se kod njega radi gotovo o iluziji, o nečemu što zapravo ne postoji. Reč je o bivstvovanju duha. U Hegelovom shvatanju, međutim, ne samo da se ne radi o iluziji, već su pojam i bivstvovanje duha kao objektivnog apsolutna supstancija onoga čije postojanje niko neće poricati, a to je čovekov svet. Ako se pretpostavi da se do pojma objektivnog duha može doći samo kroz čvrsto držanje određenja, a da se tek nakon toga može zauzeti kritički stav i pojam staviti u razvoj i posredovanje, onda se kao neposredni cilj rada postavlja izvođenje ovog pojma kroz tri određenja: određenja duha u odnosu na prirodu, određenje objektivnog duha u odnosu na subjektivni duh i određenje objektivnog duha u odnosu na apsolutni duh sledeći samog Hegela.
FIHTEOVA IDEJA BOGA
Authors: VLAŠKI STANKO
Published: May 2017

Istovremeno prihvatanje stava da bog nije i poricanje optužbe za ateizam moguće je samo ako se demonstrira da to jeste nije ono najviše što se o bogu može izgovoriti. Čitav Fihteov filozofski rad počivao je na nastojanju da se čin iznova otkriva kao ono što suštinski prethodi svemu što jeste i onome jeste sâmom, svakoj činjenici, zbog čega se i njegovo razmatranje ideje boga može sagledati kao bitna etapa u filozofskoj borbi da se sloboda prizna kao najviše načelo svakog ljudskog znanja i bitka uopšte, a koje, kao takvo, ostaje zaključano za razumsku pojmovnost. Nasuprot često zastupanoj interpretatorskoj tvrdnji o antagonizmu između ideje boga i misli o sebestavljajućem Ja učenja o znanosti, autor je sklon da tvrdi da Fihte, misleći boga kao čisto delanje i kao moralni poredak sveta, zapravo misli isti proces samooslobađanja čovečnosti koji je izražen prvim načelom učenja o znanosti.
NASTAVA FILOZOFIJE U KARLOVAČKOJ GIMNAZIJI U PERIODU IZMEĐU DVA SVETSKA RATA
Authors: KALUĐEROVIĆ ŽELJKO
Published: May 2017

U radu je ispitivana zastupljenost filozofskih predmeta i tema u nastavi u Karlovačkoj gimnaziji u periodu između Prvog i Drugog svetskog rata. Nakon podrobne analize „Izveštaja” i drugih dostupnih primarnih i sekundarnih izvora o radu Gimnazije, autor je izveo sledeći zaključak: Dešavale su se promene naziva filozofskog predmeta (najpre je to bila Filozofska propedeutika a potom Osnovi filozofije), obima nastave iz njega (u četrnaest razmatranih „Izveštaja” on je iznosio četiri časa nedeljno, po dva časa u svakom od dva završna razreda Gimnazije, dok su u osam „Izveštaja” filozofska predavanja održavana samo dva časa nedeljno u osmom razredu), sadržaja izlaganja (Logika i Psihologija zajedno, samo Logika, samo Psihologija), korišćenih knjiga u nastavi (Logika za srednja učilišta, Psihologija za srednja učilišta, (Đ. Arnold), Psihologija za srednje i stručne škole (B. Lorenc), Logika, Za učenike učiteljskih i drugih srednjih škola (B. D. Marković), Osnovi psihologije: za srednje i stručne škole (B. Petronijević), Logika za školsku i privatnu upotrebu (S. Ristić), kao i profesora (ukupno šest: Dušan Spernjak, Panajot Miodragović, Jovan Marčetić, Simeun Grozdanić, Vladimir Vujić i Milivoj Ivančević), ali one su, u godinama koje su sledile do početka Drugog svetskog rata, retko koincidirale izmenama nastavnih planova i programa, kao i donetim zakonima, propisima i uredbama. Istraživanje je, štaviše, pokazalo da je nastava iz filozofije u Karlovačkoj gimnaziji imala osobenu evoluciju, kao i da je ta evolucija u značajnoj meri bila nezavisna od implementiranih promena.
Usage profile and out-of-pocket health expenses of patients visiting a private medical office to receive dental care treatmens. Reforma, Chiapas, 2015
Authors: Flores Morales Jonatan , Ramírez-Mendoza Jeannette , Morales-García Manuel Higinio
Published: May 2017

Objetive. To describe the social and labor characteristics, usage profie, satisfaction and dissatisfaction of users in regards to the out-of-pocket health expenses of patients enjoying social security when visiting a private dentistry offi.
Material and method: An observational, analytical study was conducted in a population of 84 private practice users. The sampling was simple random, using a questionnaire that measures the use and out-of-pocket dentistry expenses.
Results: The surveyed patients receive a wage, have a formal employment, and are affiated to a social security institution. Regarding the procedures undertaken to receive dental care in the social security institution, 60% of the users were dissatisfid, 41.7% answered that they never received the adequate treatment, and 78.6% stated they were not satisfid. However, in private dental offis, 56% of the patients stated they were completely satisfid with the treatment received and with the promptness with which they received care and 100% stated they would defiitely return to receive dental care. Conversely, over 70% was dissatisfid with the high cost of treatments, one third was not satisfid with the amount paid or the treatment provided at the private offis, and 44% categorically stated that the usage of private care had a considerable impact on their economy.
Conclusions: The patients affiated to a social security institution do not seek dental care in the dental area due to the procedures they must follow. The users rather seek private care due to the promptness in service, the dentistpatient relation, the information received, despite the high cost of the treatment and its direct impact on their personal and family economy.
EL HOSPITAL DE LA MUJER EN SU LUCHA CONTRA EL CANCER CERVICO UTERINO
Authors: Bocanegra Broca Yrma Del C.
Published: May 2017

En México el cáncer de cuello de matriz constituye la primera causa de
mortalidad por neoplasias malignas entre las mujeres de 25 años y más.
Diariamente se registran en México alrededor de 12 muertes por esta causa, lo que representa una verdadera inquietud de genero e injusticia social, con mayor incidencia en las entidades federativas del sureste del país, para abatir este importante problema de salud pública, el programa nacional de salud 2001-2006, establece como una de sus estrategias sustantivas el programa de acción para la prevención y control del cáncer cervico uterino, cuyo propósito es disminuir la mortalidad por este tipo de neoplasia entre la población femenina de 25 años y mas, es de aclarar que este programa ya existía antes del 2001 y este nos ha permitido disminuir la mortalidad por cáncer Cervico uterino en algunos estados de la República Mexicana, especialmente en aquellos en donde las autoridades de salud han puesto interés en este programa como es el estado de Tabasco.
LA INTERSECTORIALIDAD. CONCEPTUALIZACIÓN. PANORAMA INTERNACIONAL Y DE CUBA
Authors: Castell Florit-Serrate Pastor
Published: May 2017

La salud aparece como un producto social en la cual sus actores y las acciones, trascienden significativamente las fronteras del denominado “sector salud,” por lo que se requiere de una respuesta social organizada, sin la cual el enfoque no sería sistémico y por tanto, el nivel de sinergia que se podría alcanzar sería muy bajo. La intersectorialidad forma parte importante de esa respuesta social organizada. Consiste fundamentalmente en convertir la cooperación fortuita o casual en
acciones que lidereadas por el sector salud se orienten estratégicamente a aquellos problemas, donde las actividades de otros sectores pueden ser decisivas. Lo anterior queda plenamente demostrado cuando se estudian los elementos influyentes o determinantes de la salud y se interrelacionan con los sectores que pueden actuar positivamente en el problema de salud. Las intersectorial se compone de tres grupos de factores: determinantes, condicionantes y desencadenantes. El estudio de dichos factores es una condición básica para un enfoque inteligente de la intersectorialidad. La importancia de la intersectorialidad para los sistemas de salud es aceptada y defendida ampliamente, sin embargo esta demostrado que falta mucho aún para pasar del discurso, a la acción y en consecuencia a los resultados.
Tooth whitening recovers the color of pre-stained composites
Authors: Farinon Camila Bruscato , Pasqualotto Giovanna Signori , Carraro Kauani , Rodrigues Junior Sinval Adalberto
Published: May 2017

Aim: To assess the effect of home-whitening on aged and stained composite. Methods: Fifteen disc-shaped specimens (10 mm diameter x 2 mm thick) of Filtek Z350XT, shade A2E were fabricated, polished and embedded in wax, leaving exposed the top surface. The specimens were allocated to three groups (n=5): A – the specimens remained dry; B – conditioning in distilled water and; C – conditioning in distilled water and coffee. They were next subjected to whitening with 10% carbamide peroxide (Whiteness Perfect) for 4 h daily for 1, 2 and 4 weeks. Shade was measured with a spectrophotometer Easyshade and expressed based on the CIE L*a*b* system (ΔE*). Surface roughness was measured with a roughness meter (Ra-µm). Data were analyzed with two-way ANOVA and Tukey’s test (α=0.05). Results: Conditioning, grouping and the interaction between both, influenced the ΔE* (p<0.0001), which exceeded the 3.3 threshold for visible color change after conditioning of Group C in black coffee. Whitening for 1 week significantly reduced ΔE* in this group. There were no significant changes in surface roughness. Conclusions: Home-whitening did not alter significantly the color of the nanocomposite, except when it was previously stained. One-week whitening was sufficient to recover color change to an acceptable level.
Comparison of the indentation strength and single-edge-v-notched beam methods for dental ceramic fracture toughness testing
Authors: Domingues Natália Bertolo , Galvão Beatriz Regalado , Ribeiro Sebastião , Almeida Junior Antonio Alves de , Longhini Diogo , Adabo Gelson Luís
Published: May 2017

Aim: To study influence of the cooling rate after sintering a veneering porcelain (Vita VM9) on fracture toughness by indentation strength (IS) and single-edge-v-notched beam (SEVNB) methods. Methods: Vita VM9 bars were sintered according to the manufacturer’s recommendation and cooled under three conditions: Slow (inside the furnace from sintering temperature to room temperature); Normal (inside the furnace from sintering temperature to 500 ºC and outside the furnace from 500 ºC to room temperature); and Fast (outside the furnace from sintering temperature to room temperature). Fracture toughness was measured by IS (n=10) and SEVNB (n=10) methods. Data were analyzed by two-way ANOVA (α=0.05). Results: The fracture toughness obtained from SEVNB (slow - 1.02±0.10; normal - 1.09±0.13; and fast - 1,02±0.18 MPa.m1/2 cooling techniques) was significantly lower than IS (slow - 1.19±0.13; normal - 1.17±0.07; and fast - 1.16±0.06 MPa. m1/2 cooling techniques). There was no significant influence of the cooling technique (p=0.012). Conclusions: The measurement technique influenced the fracture toughness values . IS method overestimated the fracture toughness values. Irrespective of the measuring method, cooling rate did not influence the Vita VM9 veneering porcelain fracture toughness.
Consumers Awareness towards Insurance Companies and their
Authors: Babu G. Suresh
Published: May 2017

The insurance sector is growing rapidly all over the world. The insurance industry is gaining key position in the world economy and playing a significant role to cover the life and business risk of millions. At present, the insurance industry is in a nascent stage. The impact of privatization in risk business in India has shown its impact on transformation from the state of monopoly to mushrooming companies offering innovative products to the Indians. The growth in the life insurance sector has shown new heights and the functioning of private companies has given tough challenge to Life Insurance Corporation of India. Within a short span of time, private insurance companies have acquired more than 25 per cent of the life insurance market. Many changes have taken place in the processes and procedures of insurance business in terms of its format and products as well the mindset, motives, interests, and expectations on the part of the customers also. The customers have become more vigilant, calculative and calibrated not only in terms of risk coverage but look forward for safety of investment and higher rate of returns on the saving in insurance sector
Discrimination of Beer Based on E-tongue and E-nose Combined with SVM: Comparison of Different Variable Selection Methods by PCA, GA-PLS and VIP
Authors: Men Hong , Shi Yan , Fu Songlin , Jiao Yanan , Qiao Yu , Liu Jingjing
Published: May 2017

Multi-sensor data fusion of E-tongue and E-nose can provide a more comprehensive and more accurate analysis results. However, it also brings some redundant information, it is a hot issue to reduce the feature dimension for pattern recognition. In this paper, the taste-olfactory data fusion based on E-tongue and E-nose combined with Support Vector Machine (SVM) was used to classify five different beers. First, the taste and olfactory feature information were obtained based on E-tongue and E-nose. Second, the original feature data of single system were fused, then Principal Component Analysis (PCA) was applied to extract principal components, Genetic Algorithm-Partial Least Squares (GA-PLS) was used to select the characteristic variables, 20 subsets were generated with those variables based on the best Variable Importance of Projection (VIP) score. Finally, the classification models based on SVM were established, also c and g of SVM were calculated by Grid Search (GS), Genetic Algorithm (GA), and Particle Swarm Optimization (PSO), the classification results of all subsets were obtained. The results showed that the classification accuracy using data fusion was much higher over single E-tongue and single E-nose, and the variable selection method by VIP had the best classification performance in #12 subset coupled with GA-SVM.