bluuebunny/crossref_metadata_2025 huggingface dataset:
VALORACIÓN FINANCIERA Y AMBIENTAL EN LAS ORGANIZACIONES
Authors:   Corporación Universitaria Republicana, GOMEZ ANGIE , MARTINEZ LEIDY , AVILA SAMIR
Published: January 2022

This article analyzes the subject of financial and environmental assessment in companies, highlighting in this sense the environmental accounting that allows to identify the necessary information to intervene from the educational and financial aspect in the social commitment to protect the environment from pollution, which is generated largely by industrialization. In this way, the relationship between management and environmental management manifests itself throughout the document with the management of the resources that a company has to provide continuity to its inmates without interrupting production or the usual performance. At the same time, environmental education in organizations is able to raise awareness about the notion of environmental responsibility, Bioethics and Corporate Social Responsibility, being fundamental pillars to mitigate at present the destruction of biodiversity and environmental damage caused to a large extent by the industrial processes generated by some organizations around the world, manifesting with this a reduction of the quality of life of living beings.
EL TRABAJO SOCIAL EN LAS BRIGADAS JURÍDICAS DE LA CORPORACIÓN UNIVERSITARIA REPUBLICANA
Authors:   Corporación Universitaria Republicana, BONILLA LUZ , GUZMAN LINA
Published: January 2022

rom the legal office of the Republican University Corporation, legal brigades are being carried out in different localities of Bogotá, where the approach to the communities has shown the need for interdisciplinarity with Social Work and the essential for the formation of citizens who think about collective projects and the construction of more equitable societies for all. In this space law students who belong to the Disability Convention of the legal office, provide legal advice in different locations discovering realities that need a transformation and that even belong to the reality of the adviser’s own environment, giving a new experience that takes them to think of a «want to change and help», forming more reflective, sensitive, understandable subjects that are aware of the differences between all people (in our case, people with disabilities, PcD). All this leads to the emergence of new questions and proposals to help, change or apply from their law career, where they are: laws, decrees, public policies and mainly the application of the «United Nations Con- vention on the Rights of people with disabilities «(2006) which was ratified by Colombia; it is struggling against pre-established models and common ways of seeing discouragement, which gave way to the social and legal limitations of PWD. In several nations in its historical line,models were used that allowed the exclusion, violation or limitation of the exercise of the right and the effective participation of PWD in conditions of equality with other members of society. Colombia has created public policies for PcD where its dignity and quality of human beings are recognized, historically it is based on the struggle that had been posed since the seventies in Europe and the United States to stop being considered second class citizens, disabled people, sick or mutilated. These campaigns and protests were aimed at allowing PWDs to form inclusive societies that accept the difference, respecting the human dignity of all people regardless of the «disability» they may have.
VALORACIÓN DE LA CÁTEDRA DE LA PAZ EN COLOMBIA
Authors:   Corporación Universitaria Minuto de Dios, JIMENEZ ADRIANA , JIMENEZ AIDA
Published: January 2022

he chair for peace in Colombia is a viable and focused proposal that aims to create a space to articulate the learning process with cultural reflection, acquiring citizen competencies that promote rights in situations of the current context, improving the quality of life. However, a problem that differs in the process is the lack of appropriation and suitability by the teachers of the proposed issues and lack of commitment to the identity of the country and its peace process.
E-BOT PLATAFORMA ROBÓTICA DE APOYO EN LA ENSEÑANZA DE ALGORITMOS Y PROGRAMACIÓN
Authors:   Corporación Universitaria Republicana, GÚTIERREZ JEFFERSON , CALDERON NICOLAS , FRANCO JOSE
Published: January 2022

This article presents the design and construction of a mobile robot (E-BOT) both in the hardware and in the software part, which works as a support tool for teaching processes and allows to consolidate learning in related topics. a Programming having as its scope repetitive structures, this through a series of previously constructed learning elements. E-BOT has a series of actuators (Led, oled, servomotor, motors) and sensors (ultrasound and reflective light) which are controlled by means of Arduino that allow an easy interaction of EBOT with the real world. Additionally, the construction of a verification software is carried out that allows us to validate the correct operation of all the modules built.
A CRITICAL REVIEW ON ALPHA TOCOPHEROL: SOURCES, RDA AND HEALTH BENEFITS.
Authors:   Samina Kauser, Batool, Maria
Published: January 2022

Virtually 100 years before Î±-tocopherol (universally known as a "Vitamin-E") remained revealed. It was essential component to preclude fetal recommencement in expectant. In 1940s, Vitamin E existed recognized as the crucial part that plays in deactivating and extinguishing the free radicals that is present inside the diverse compartments of muscles.
TYPHOID CONJUGATED VACCINE: PAKISTAN ROLLS OUT NEW TYPHOID VACCINE TO FIGHT RESISTANT STRAIN
Authors:   Samina Alam, Dilshad Huma
Published: January 2022

Typhoid is a contamination of micro organism that could result in excessive fever, diarrhea and vomiting. Could be fatal. This is resulting from the Salmonella Typhi micro organism
KRITIK SOSIAL DALAM PUISI AKU MASIH SANGAT HAFAL NYANYIAN ITU KARYA MUSTOFA BISRI (PENDEKATAN HERMENEUTIKA PAUL RICOEUR)
Authors: Kholiq Abdul , Tengsoe Tjahjono
Published: January 2022

Penelitian ini bertujuan untuk menganalisis makna simbol “Nyanyian Itu” dan kritik sosial dalam puisi “Aku Masih Sangat Hafal Nyanyian Itu” karya Mustofa Bisri. Penelitian ini menggunakan pendekatan kaulitatif. Pengumpulan data pada penelitian ini menggunakan teknik dokumentasi. Pendokumentasian puisi “Aku Masih Sangat Hafal Nyanyian Itu” dilakukan dengan mendownload puisi tersebut di internet. Penganalisisan data pada penelitian ini menggunakan pendekatan hermeneutika Paul Ricoeur Hasil penelitian tersebut menunjukkan bahwa makna simbol nyanyian itu dalam puisi “Aku Masih Sangat Hafal Nyanyian Itu” katya Mustofa Bisri digambarkan sebagai 1) lagu yang biasa dilantunkan penyair dengan teman-temannya pada waktu masa kecil; 2) nyanyian kesukaan siswa pada saat di sekolah rakyat; 3) lagu wajib yang harus dilantunkan siswa setiap hari; 4) lagu yang digubah syairnya dengan subjek yang sama. Kritik sosial dalam puisi  “Aku Masih Sangat Hafal Nyanyian Itu” karya Mustofa Bisri, yaitu 1) banyak orang yang saat ini terlalu individualis yang mementingkan keperluan dan kepentingannya masing-masing; 2) banyaknya orang yang memiliki sifat keduniawian yang tinggi (hedonis); 3) banyaknya orang yang saling berebut kuasa.
Kompatibilitas Konsep Sustainable Development pada Laporan Corporate Social Responsibility
Authors: Yuliarini Sarah , Inayati Titik
Published: January 2022

Intrinsic aspect  that is owned by internal management on policies related to the corporation social responsibility (CSR) program leads to the results the company wants to achieve their purposes. Based on the context of intrinsic factors, this study intends to explore facts from the internal management of a company regarding the compatible concept for sustainable development (SD) as company achievements on CSR as a program that is run by the company. This research was conducted with a qualitative approach and strengthened by a triangulation process with supporting data from the company's Sustainability Report (SR). Monetary quantity parameter or economy aspect of corporate wealth (such as tangible assets be classified as internal features or extrinsic factor) have relatable impact to sustainable development (SD), with semantic analysis method revealed intrinsic factor have not it. The contribution to outcomes is to create a conceptual framework for categories associated with sustainable development through the CSR program that is required by the government for companies to implement in Indonesia. The implication of the research is found the CSR reporting supporting economic aspect, strengthen sustainable development in practices.
The Fact of Inter-Regional Cooperation on Environmental Law in Lampung, Indonesia
Authors: Akib Muhammad , Sumarja FX. , Yuwono Slamet Budi , Soerjatisnanta Hieronymus
Published: January 2022

This study aims to analyze the regulation of inter-regional cooperation law in environmental management in Lampung Province. The findings of this research are expected to be a basis in determining the model of legal policy of interregional cooperation in the field of environmental management in Lampung Province. Thus, the implementation of regional autonomy will be protected from regional ego and sector ego, and will eventually realize the ultimate goal of regional autonomy in the field of environment that is the welfare of local communities and environmental sustainability. This research method using socio-legal approach. The practice is primarily concerned with Local Government involvement and communities in upstream-downstream relationships in watershed (DAS) management in Lampung Province. Therefore, this study, in addition to reviewing the environmental policy of the Lampung Provincial Government, also examines district and city government environmental policies, especially in environmental management involving more than one district / city. The results showed that the legal arrangement of interregional cooperation in management of the environment in Lampung Province has not been specifically regulated. The basis of inter-regional cooperation is based only on the principles of regional autonomy and has not been based on the ecological characteristics and conditions in the region. Therefore, the approach still tends to be economic oriented and regional administration.The ideal concept is that the legal arrangement of cooperation inter-regional in the field of environment should be based on the principle of ecoregion.
The Feasibility of Guided Inquiry –Based Natural Sciences Module to Object Materal and Form Changes
Authors: Aminah Siti , Yunus Rahmat , Suyidno Suyidno
Published: January 2022

Inquiry is the essence of science learning, but their activity is rarely trained in elementary school students. Therefore, the purpose of this research is to produce a guided inquiry-based science module that is appropriate to improve students’ learning outcomes on material objects and changes in form. This research is part of the educational research design with Tessmer's formative evaluation, namely at the field test stage. The module trial used a quasi-experimental one-group pre-test and post-test design. The science module was declared valid by the validators, was then tested on 30 fifth graders in an elementary school in Kapus Regency, Central Kalimantan. The research data was obtained through the instrument of observing the module implementation and learning outcomes tests (products and processes). The results of the observations show that all inquiry activities in the module can be carried out properly. In addition, the acquisition of n-gain student learning outcomes is 0.43 with moderate criteria. Thus, the guided inquiry-based science module is feasible to use in science learning.
Vertical and horizontal datums used in the Lower Mississippi Valley for US Army Corps of Engineers projects
Authors: Dunbar Joseph
Published: January 2022

Six geodetic datums have been used by the US Army Corps of Engineers (USACE), Mississippi River Commission (MRC), for river surveys in the Lower Mississippi Valley (LMV). These legacy elevation datums are the Cairo datum, the Memphis datum, the Mean Gulf Level (MGL), the Mean Sea Level (MSL), the National Geodetic Vertical Datum (NGVD) 1929, and the North American Vertical Datum 1988 (NAVD88). The official geodetic datum currently prescribed by the USACE is NAVD88 (USACE 2010). In addition to these different geodetic datums, hydraulic datums are in use by the USACE for rivers, lakes, and reservoir systems. Hydrographic surveys from the Mississippi River are typically based on a low water pool or discharge reference, such as a low water reference plane (LWRP), an average low water plane (ALWP), or a low water (LW) plane. The following technical note is intended to provide background information about legacy datums used in the LMV to permit comparison of historic maps, charts, and surveys pertaining to the Mississippi River in the LMV. The purpose of this report is to provide background information and history of different published horizontal and vertical datums used for presentation of hydrographic survey data from the Mississippi River. The goal is to facilitate understanding of differences with comparison to other historic surveys for change-detection studies along the river. Conversion values are identified herein for the earlier surveys where appropriate, and methods are presented here to evaluate the differences between earlier and later charts and maps. This report is solely intended to address the LMV area and historic surveys made there. This note is not applicable to areas outside of the LMV. Throughout this technical note, historic hydrographic surveys and data from the Memphis, TN, to Rosedale, MS, reach will be used as examples of features of interest for discussion purposes. Selected historic hydrographic survey sheets at Helena, AR, are included as Plates 1 to 3 (Appendix C) of this document and will be used as examples for discussion purposes.
Modeling Horizontal Salt Cavern Leaching in Bedded Salt Formations
Authors: Zeng Quanshu , Wang Zhiming , Wang Jinchao , Wanyan Qiqi , Ding Guosheng , Li Kang
Published: January 2022

The leaching of a salt cavern will trigger a series of rock-fluid interactions, including salt rock dissolution, cavity expansion, and brine transport caused by convection, turbulence, and diffusion effects. These interactions have influences on one another. The primary objectives of this study include developing a 3D multiphysical coupled model for horizontal salt cavern leaching and quantifying these interactions. The species transport equation and standard κ-ε equation were combined to describe the brine transport dynamics within the cavity. Based on the velocity and concentration distribution characteristics predicted, the interface movement equation implemented with mesh deformation techniques was applied to describe the cavity expansion. Next, the Volgograd cavern monitored data were collected for model validation. The predicted results are consistent with the field data. The average relative errors are 11.0% for brine displacing concentration and 4.5% for cavity volume. The results suggest that the cavity can be divided into three regions, including the main flow region, circulation region, and reflux region. The results also suggest that the brine concentration distribution is relatively uniform. With the dissolution threshold angle and anisotropic dissolution rates considered, the resultant cavity cross section is crown top and cone bottom. The results also show that the cavity can be divided into dissolution and erosion sections according to its position relative to the injection point.
Inhibitory Effects of Doxycycline on Tumor Progression In vitro and on Metastases in Early-Stage Osteosarcoma Xenografts Mice.
Authors: Hadjimichael Argyris Costas , Foukas Athanasios F. , Papadimitriou Evangelia , Peristiani Chrysostomi , Chaniotakis Ioannis , Pergaris Alexandros , Theocharis Stamatios , Sarantis Panagiotis , Psyrri Amanda , Mavrogenis Andreas F. , Savvidou Olga D , Kaspiris Angelos , Papagelopoulos Panayiotis J. , Armakolas Athanasios
Published: January 2022

Introduction. Osteosarcoma (OS) is the commonest primary osseous malignant tumor with a high propensity to metastasize in lungs. Pulmonary widespread micrometastatic lesions are present in up to 80% of patients at initial diagnosis and they are associated with significantly worse prognosis. Doxycycline (Dox) is a synthetic tetracycline that has been shown to have anti-cancer properties in vitro and in vivo, and inhibit angiogenesis, effects that may prove beneficial for several types of cancer. The aim of the present work was to study how Dox affects OS cells’ growth in vitro and in vivo and OS-driven pulmonary metastasis in vivo. Methods. In vitro, the effect of Dox was measured in MG-63 and 143B human OS cells’ viability, apoptosis, and migration. In vivo, highly metastatic143B cells were orthotopically implanted into the tibia of SCID mice and tumor growth as well as pulmonary metastases between Dox treated and untreated, non-amputated and early amputated xenografts were examined. Results. Dox decreased the viability, inhibited the migration, and induced the apoptosis of OS cells in vitro. In vivo, Dox significantly enhanced tumor necrosis at primary OS sites, similarly to its in vitro effect. It also decreased the expression of Ki67, metalloproteinases 2 and 9 (MMP2 and MMP9), vascular endothelial growth factor A (VEGFA) and Ezrin in primary tumors. It also decreased the circulating VEGFA and MMP9 protein levels, in line with the decreased metastatic burden in Dox-treated mice in both non-amputated and early amputated xenografts. Conclusions. Our results suggest that adjuvant administration of Dox may decrease OS growth and development of pulmonary metastases. Administration of Dox in combination with surgical resection and standard chemotherapeutic protocols in the early-stages of OS treatment is also supported. Moreover, Dox administration prior to the development of clinically detectable pulmonary macrometastases, is associated with enhanced clinically benefits from its anti-metastatic effect.
Sleep And Positive Emotions In Adolescents With Anorexia Nervosa In Relation To The Covid-19 Pandemic
Authors: Rossi Lucia , Silva Catarina Da , Charvin Isabelle , Fonseca David Da , Bat-Pitault Flora
Published: January 2022

Purpose: The recent COVID-19 pandemic, and its consequent lockdown measures raised concerns about people’s mental health. Identified vulnerable groups may be especially at risk. This study investigated the impact of this unprecedent situation on sleeping patterns and emotionality in adolescents with anorexia nervosa (AN).Methods: Variations in sleeping patterns and emotionality of 101 adolescents with AN, assessed during the pandemic (Covid-19 Group), and the year before (No-Covid-19 Group) were analyzed. We further investigated these variations over time: before the lockdown, 9 months later and after the lockdown.Results: Adolescents in the Covid-19 Group had significantly higher rates of sleep alterations and lower rates of positive emotions, compared to the No-Covid-19 Group. A higher insomnia severity index score and a tendency to lengthen sleep latency time were also associated with the pandemic period. Considering three different groups of patients over time, the kinetics of the impact of the changes shows that the worsening of values is not strictly limited to the acute lockdown phase but is increasing over time. Conclusions: These sleep and emotionality features could have participated to increase severity and incidence of AN in adolescents during the Covid-19 pandemic. As such, these features could represent therapeutic targets to optimize the care of adolescents with AN, particularly urgent to improve considering the kinetic of the deterioration. Tools such as those provided by cognitive behavioral therapy for insomnia (CBTi) and by the positive psychology seem appropriate to guide clinicians in this context. Level of evidence: Level V, descriptive study (evaluation data retrospectively studied).
A New Method for Detecting Sleep Apnea
Authors: Xin Xiong , yaru zhang , Sanli Yi , Chunwu Wang , Ruixiang Liu , Jianfeng He
Published: January 2022

Sleep apnea is a sleep disorder that can induce hypertension, coronary heart disease, stroke and other diseases, so the detection of sleep apnea is clinically important for the prevention of these diseases. In order to improve the detection performance and verify which physiological signals are better for sleep apnea detection, this paper uses multi-channel signal superposition and channel summation to improve the content of valid information in the original signal. Thirty features are analyzed by Relief feature selection algorithm. Finally, 15 features were used to build a classification model and support vector machine (SVM) was used for classification. The experimental results showed that the highest accuracy of 96.24% was achieved when electrocardiogram (X2) and electroencephalogram (C3-A2) channels were used for channel summation.
Mitochondrial Proteomics and Transcriptional Analysis of Cytoplasmic Male Sterility in Sugar Beet using iTRAQ and qRT–PCR
Authors: Liu Tianjiao , Cheng Dayou , Han Xue , Cui Jie , Dai Cuihong , Li Junliang , Liang Naiguo
Published: January 2022

Sugar beet (Beta vulgaris L.) is an important raw material for the sugar industry, and its output is second only to sugar cane. Cytoplasmic male sterility (CMS) is a phenomenon of pollen abortion that has important implications in sugar beet hybrid breeding. Male plant sterility is usually considered to be associated with mitochondrial dysfunction. Although mitochondrial genes associated with male sterility have been well explored, the different mitochondrial proteomics of CMS in sugar beet are still poorly understood. In this study, differentially expressed mitochondrial proteomic analysis was performed on the flower buds of the male sterile line (DY5-CMS), its maintainer line (DY5-O) and a fertility restorer line (CL6), using an isobaric tag for relative and absolute quantitation (iTRAQ) technology. A total of 2260 proteins were identified by mass spectrometry, of which 538 were differentially expressed proteins. Most of them were involved in protein metabolism, carbohydrate and energy metabolism, and binding. More specifically, some cysteine and methionine metabolism proteins (A0A0J8BGE0, A0A0J8CZM6, A0A0J8D7W0 and A0A0J8BCR7) may play important roles during the formation of CMS. This study provided an in–depth understanding of the CMS molecular mechanism at the protein level in sugar beet.
Marein prevented LPS-induced osteoclastogenesis by regulating the NF-κB pathway in vitro
Authors: Li Yuling , Zhang Jing , Yan Caiping , Chen Qian , Xiang Chao , Zhang Qingyan , Wang Xingkuan , jiang ke
Published: January 2022

Gram-negative bacterial infection causes many bone diseases such as osteolysis, osteomyelitis and septic arthritis. Lipopolysaccharide (LPS), a bacteria product, played an important role in this process. Drugs that inhibited LPS-induced osteoclastogenesis were urgently needed for the prevention of bone destruction in infective bone diseases. Marein, a major bioactive compound of Coreopsis.tinctoria, which possesses anti-oxidative, anti-inflammatory, anti-hypertensive, anti-hyperlipidemic and anti-diabetic effects. In this study, the effect of marein on RAW264.7 cells was measured by CCK-8 assay; TRAP staining was used to determine osteoclastogenesis; the levels of osteoclast-related genes and NF-κB-related proteins were analyzed by WB; the levels of pro-inflammatory cytokines were quantified by ELISA. Our results showed that marein inhibited LPS-induced osteoclast formation from osteoclast precursor RAW264.7 cells. The effect of marein was related to its inhibitory function on expressions of pro-inflammatory cytokines and osteoclast-related genes including RANK, TRAF6, MMP-9, CK and CAⅡ. Besides, marein treatment could inhibit LPS-induced activation of NF-κB signaling pathway in RAW264.7 cells. Meanwhile, inhibition of NF-κB signaling pathway decreased the formation of osteoclasts and expression of pro-inflammatory cytokines which were LPS-induced. Collectively, marein could prevent LPS-induced osteoclast formation in vitro by regulating NF-κB signaling pathway. These findings provided evidence that marein might be beneficial as a valuable choice for the prevention and treatment of bacteria-induced bone destruction disease, and gave new insights for understanding its possible mechanism.
An anomalous atmospheric river linked to the late June 2021 western North America heatwave
Authors: Mo Ruping , Lin Hai , Vitart Frédéric
Published: January 2022

Atmospheric rivers (ARs) are long and narrow bands of enhanced water vapour flux concentrated in the lower troposphere. Many studies have documented the important role of cold-season ARs in producing heavy precipitation and triggering extreme flooding in many parts of the world. However, relatively little research has been conducted on the warm-season ARs and their impacts on extreme heatwave development. Here we show an anomalous warm-season AR moving across the North Pacific and its interaction with the western North American heatwave in late June 2021. We call it an “oriental express’’ to highlight its capability to transport tropical moisture to the west coast of North America from sources in Southeast Asia. Its landfall over the Alaska Panhandle lasted for more than two days and resulted in significant spillover of moisture into western Canada. We provide evidence that the injected water vapour was trapped under the heat dome and may have formed a positive feedback mechanism to regulate the heatwave development in western North America.
Response in Growth Performance, Physico-chemical Properties, and Fatty acid Composition of Broiler Meat to Different Levels of Mucuna Pruriens Seed Meal
Authors: Mthana Makiwa Simeon , Gajana Christian Sabelo , Moyo Bethwell , Hugo Arno , Makhamba Nasiphi , Thabethe Fortune
Published: January 2022

The study was conducted to determine the response in growth performance, physicochemical properties and fatty acid composition of broiler meat fed incremental levels of M. pruriens seed meal. A total of 112 Cobb 500, seven days old, unsexed broiler chicks with body weight of 150 ± 5.47 g/bird (mean ±SD) were used. Chicks were allotted to pens in a completely randomized design hence assigned to four experimental diets containing 0, 10, 15, and 20% of MPSM, respectively. Each diet was offered ad libitum with clean water to 28 broilers in each treatment. There was a linear decrease in average daily feed intake (ADFI), average daily gain (ADG) and final body weight (FBW) with incremental levels of MPSM (P < 0.05). Feed conversion ratio (FCR) increased linearly with increasing MPSM levels while Final Body Wight (FBW) decreased linearly with increasing levels of MPSM (P < 0.05). Meat pH24 and colour parameters showed no relationship with increasing levels of MPSM (P > 0.05). Thawing loss, carcass weight and cooking loss showed a linear increase with increasing levels of MPSM (P < 0.05). However, shear force showed a linear decrease with increasing levels of MPSM (P > 0.05). Muscle fat, fat free dry matter (FFDM) and moisture, mono-unsaturated fatty acids and margaric acid showed no relationship with increasing levels of MPSM (P > 0.05), however, a linear decrease (P < 0.05) on myristic acid and palmitic acid with incremental levels of MPSM was observed. Arachidic acid, and α-Linolenic acid increased linearly with inclusion level of MPSM (P < 0.05). Other poly-unsaturated fatty acids, fatty acid ratios and health lipid indices indicators showed no relationship with increasing levels of MPSM (P > 0.05). Increasing inclusion levels of MPSM impairs growth performance of broilers and may also improve broiler quality and fatty acid some fatty acids.
Effect of Physical Therapy on Bone Remodelling in Preterm Infants. A Multicenter Randomized Controlled Clinical Trial
Authors: Torró-Ferrero Galaad , Fernández-Rego Francisco Javier , Jiménez-Liria Rosario , Agüera-Arenas Juan Jose , Piñero-Peñalver Jessica , Sánchez-Joya María del Mar , Fernández-Berenguer María Jesús , Rodríguez-Pérez Mónica , Gomez-Conesa Antonia
Published: January 2022

Background: Preterm infants have a low level of bone mineralization compared to those born at term, since 80% of calcium incorporation occurs at the end of pregnancy. The purpose of the present study was to investigate the effect of reflex locomotion therapy on bone modeling and growth in preterm infants and to compare its effect with those of other Physiotherapy modalities.Methods: A multicentre randomized controlled clinical trial was conducted (02/2016 – 07/2020). 106 preterm infants born at the Virgen de la Arrixaca University Clinical Hospital, the General University Hospital of Elche and the Torrecárdenas Hospital in Almería, between 29 and 34 weeks with hemodynamic stability, complete enteral nutrition and without any metabolic, congenital, genetic, neurological or respiratory disorders were evaluated for inclusion. Infants were randomly assigned to three groups: one group received reflex locomotion therapy (EGrlt); another group received passive mobilizations with gentle joint compression (EGpmc); and the control group received massage (CG). All treatments were carried out in the neonatal units lasting one month. The main outcome measure was bone formation and resorption measured with bone biomarkers. A mixed ANOVA was used to compare the results of bone biomarkers, and anthropometric measurements. Results: Infants were randomized to EGrlt (n = 38), EGpmc (n = 32), and CG (n = 36). All groups were similar in terms of gender (p = 0.891 female 47.2%), gestational age (M = 30.753, SD = 1.878, p = 0.39) and birth weight (M = 1413.45, SD = 347.36, p = 0.157). At the end of the study, significant differences were found between the groups in their interaction in bone formation, measured with osteocalcin [F (2,35) = 4.92, p = 0.013, ηp2 = 0.043], in benefit of the EGrlt. Conclusions: Reflex locomotion therapy has been effective in improving bone formation, more so than other Physiotherapy modalities. Therefore, reflex locomotion therapy could be considered one of the most effective physiotherapeutic modalities for the prevention and treatment of osteopenia of prematurity Trial registrstion: Trial retrospectively registered at ClinicalTrials.gov. First posted on 22/04/2020. Registration number: NCT04356807. URL: https://clinicaltrials.gov/ct2/show/NCT04356807?cond=Physical+Therapy+to+Prevent+Osteopenia+in+Preterm+Infants&draw=2&rank=1
Uptake of Screening Mammogram in West-central Illinois During COVID-19 Pandemic: Lessons Learned
Authors: Agboola John Owoade , Ayosanmi Oluwasola Stephen , Bezold Maureen P. , Mogbojuri Oluwatobi
Published: January 2022

Objectives. The study aims to reveal the trend of mammogram uptake in seventeen rural counties in Illinois to understand how the COVID-19 pandemic is influencing breast cancer screening in the area.Methods. Aggregated data on mammography screening for west central Illinois was provided by the Illinois Hospital Association. Data for 2018 and 2019 was used to determine the typical monthly and annual screenings for the two years before the onset of COVID-19. Then, the two years' data was compared to the 2020 data. The monthly mean values for the aggregated 2018 and 2019 data were generated as the base "year" to compare with the monthly value for 2020. Paired T-Test analysis was used to find if there were any statistically significant differences the years and between the base year and 2020.Results. January 2020 revealed an uptick to 2,921, which is more than the uptake for January 2018 (2700) and January 2019 (2488), and 13% greater than the mean value of 2,594 for the previous two years. This was followed by a gradual decrease in uptake in February 2020 by 4% compared to previous years at a mean of 2518 and a further decline in March (44%), with a drastic fall (98%) by April 2020 at 56 screening mammograms in all 17 counties. The lowest uptake in any three months occurred from March through May 2020. Compared to previous years, increase in uptake was noted across the region in 2020 June (8%) and July (4%) after the pandemic restrictions were relaxed. Overall, the total uptake in 2020 was 15% less than the average annual uptake for 2018-2019 with a deficit of 5,537. There was no statistically significant difference in mammogram uptake across the three years.Conclusion. The findings reveal that there was a significant reduction in uptake during the pandemic restriction period. However, increased uptake during the rest of the year effectively mitigated this reduction to such an extent that there was no statistically significant downturn compared to each of the previous two years. A rising trend in total annual uptake noted in preceding years could have continued without the COVID-19 event.
Quadruple Term Gestation of Quadri-Chorionic Quadri-Amniotic Pregnancy After Artificial Insemination: A Case Report
Authors: Caballero-Reyes Mauricio , Medina-Rivera Diana , Alas-Pineda César , Mejía-Raudales Beatriz , Gaitán-Zambrano Kristhel , Rubi Tesla Valle
Published: January 2022

Background: To solve infertility, modern science has promoted assisted reproduction techniques such as in vitro fertilization, ovulation induction, and artificial insemination. Quadruple-type multiple pregnancies occur in 1 of every 500,000 pregnancies, and it is estimated that 90% occur due to assisted reproductive techniques, which often lead to numerous complications. Case presentation: Here we present a case of a 33-year-old woman, who desired pregnancy, but had a history of primary infertility diagnosed by hysterosalpingography, and endometriosis, which was treated by fulguration and medical management. Concomitantly, the patient was anovulatory. To fulfill her wish, she underwent homologous artificial insemination, after treatment, she successfully conceived quadri-chorionic quadri-amniotic infants, who were born at 37.2 weeks, without perinatal or maternal complications.Conclusion: This paper presented the parameters of prenatal care, appropriate management approach, and successful resolution without maternal-fetal complications despite the inherent risks of this type of pregnancy.
Mechanically axially chiral catenanes and noncanonical mechanically axially chiral rotaxanes
Authors: Goldup Stephen , Maynard John , Gallagher Peter , Lozano David , Butler Patrick
Published: January 2022

The term chiral was introduced by Lord Kelvin over a century ago to describe objects that are distinct from their own mirror image. Chirality is relevant in many scientific areas, but particularly chemistry because different mirror image forms of a molecule famously have different biological properties. Chirality typically arises in molecules due to a rigidly chiral arrangement of covalently bonded atoms. Less generally appreciated is that molecular chirality can arise when molecules are threaded through one another to create a mechanical bond. For example, when two molecular rings with chemically distinct faces are joined like links in a chain the resulting structure is chiral even when the rings themselves are not. We re-examined the symmetry properties of such mechanically axially chiral catenanes and in doing so identified a straightforward route to these molecules from simple building blocks. This also led to the discovery of a previously overlooked mechanical stereogenic unit that can arise when such a ring encircles a dumbbell-shaped axle to generate a rotaxane. These insights allowed us to produce the first highly enantioenriched axially chiral catenane and the same approach gave access to a molecule containing the newly identified noncanonical axially chiral rotaxane motif. With methods to access these structures in hand, the process of exploring their properties and applications can now begin.
Deep Eutectic Solvents For Efficient Processing of Renewable Resources Into Sustainable Biofuels and High Value-Added Carbon-Based Fine Chemicals: Recent Developments, Challenges, and Future Perspectives
Authors: Lin Yuan-Chung (Oliver) , Amesho Kassian T.T. , Mohan S. Venkata
Published: January 2022

Green chemistry techniques for the exploitation of renewable resources have emerged as beneficial techniques for producing sustainable biofuels and high value-added carbon-based fine chemicals with the potential to decrease the impact of anthropogenic activities on the environment. Despite various green chemistry technologies for processing renewable resources into different valuable products, there are still several major issues concerning the pretreatment processes and techniques, such as high cost and high-energy consumption. Thankfully, deep eutectic solvents (DESs), a potentially attractive “green solvent” biodegradable substitute to environmentally harmful organic solvents, have been progressively exploited for renewable resources processing. Therefore, the central focus of this review is to present recent developments and challenges of DESs as processing green solvents for renewable resources. We believe this comprehensive review will provide new insights towards developing state-of-the-art sustainable and new green technologies for the efficient processing of renewable resources for sustainable biofuels and value-added carbon-based fine chemicals.
GLAM: An adaptive graph learning method for automated molecular interactions and properties predictions
Authors: Li Yuquan , Hsieh Chang-Yu , Lu Ruiqiang , Gong Xiaoqing , Wang Xiaorui , li Pengyong , Liu Shuo , Tian Yanan , Jiang Dejun , Yan Jiaxian , Bai Qifeng , Liu Huanxiang , Zhang Shengyu , Yao Xiaojun
Published: January 2022

Improving drug discovery efficiency is a core and long-standing challenge in drug discovery. For this purpose, many graph learning methods have been developed to search potential drug candidates with fast speed and low cost. In fact, the pursuit of high prediction performance on a limited number of datasets has crystallized them, making them lose advantage in repurposing to new data generated in drug discovery. Here we propose a flexible method that can adapt to any dataset and make accurate predictions. The proposed method employs an adaptive pipeline to learn from a dataset and output a predictor. Without any manual intervention, the method achieves far better prediction performance on all tested datasets than traditional methods, which are based on hand-designed neural architectures and other fixed items. In addition, we found that the proposed method is more robust than traditional methods and can provide meaningful interpretability. Given the above, the proposed method can serve as a reliable method to predict molecular interactions and properties with high adaptability, performance, robustness and interpretability. This work would take a solid step forward to the purpose of aiding researchers to design better drugs with high efficiency.
Point-of-Care Urine Gram Stain for Managing Febrile Urinary Tract Infection in Adults
Authors: Taniguchi Tomohiro , Tsuha Sanefumi , Shiiki Soichi , Narita Masashi
Published: January 2022

Background

Febrile urinary tract infections (fUTIs), which include pyelonephritis, prostatitis, and urosepsis, are the most common cause of sepsis. However, the treatment has become more complex because of the world-wide increase in antimicrobial resistance (AMR). The objective of this study was to clarify whether point-of-care Gram stain (PCGS) of urine contributed to fUTI diagnosis and treatment in adults.
Methods

This hospital-based observational study was undertaken between January 2013 and March 2015 in Okinawa, Japan. All enrolled patients were adults who had been admitted to the Division of Infectious Diseases with suspected fUTI. The usefulness of PCGS results were compared for urinalysis (U/A) and urine cultures (U/Cs). The targeted therapy type and its effectiveness based on PCGS were analyzed, and each was investigated in two groups: the uncomplicated pyelonephritis group and the complicated pyelonephritis/prostatitis group.
Results

Two hundred sixty-six patients were enrolled. The results of PCGS were closely correlated with those of U/A for pyuria and bacteriuria, and moderately correlated with the results of U/C for bacterial types. In the uncomplicated group, narrow-spectrum antimicrobials such as cefotiam were initially selected in 97.9% (47/48) of patients, and their effectiveness was 97.9% (47/48). In the complicated group, the effectiveness was 84.2% (186/221) (p=0.009) despite frequent AMRs (14.7%; 32/218) and low use of broad-spectrum antimicrobials such as carbapenems (7.7%; 17/221).
Conclusion

Urine PCGS led to a more precise fUTI diagnosis and prompted clinicians to select narrower-spectrum antibiotics with high effectiveness.
Prototyping of Straight Section Components Using Incremental Shape Rolling
Authors: Essa Abdelrahman , Abeyrathna Buddhika , Rolfe Bernard , Weiss Matthias
Published: January 2022

Flexible Roll Forming (FRF) allows the forming of components with a variable cross-section along the length of the component. However, the process has only limited application in the automotive industry due to wrinkling in the flange which currently prevents the forming of high strength steels and limits the part shape complexity. This paper presents a new forming technology, Incremental Shape Rolling (ISR), where a pre-cut blank is clamped between two dies and then a single forming roll is used to incrementally form the material to the desired shape. The new process is similar to some Incremental Sheet Forming (ISF) approaches but with the difference that Incremental Shape Rolling (ISR) allows the manufacture of longitudinal components from high strength metal sheets. In this work, a numerical model of the ISR of a straight section is developed. Experimental prototyping trials are performed and are used to validate the numerical model which is then applied to analyse the new forming process. The results show that in ISR, tensile residual strains are developed in the flange. Flange wrinkling is observed and directly linked to the number of forming passes that are used in the process.
Machine-learning and Automatically Segmented Retinal Biomarkers Generate Spatial Heatmaps Predictive for Standard and Low Luminance Visual Acuity in Geographic Atrophy
Authors: Balaskas Konstantinos , Glinton Sophie , Keenan Tiarnan , Faes Livia , Liefers Bart , Zhang Gongyu , Pontikos Nikolas , Struyven Robbert , Wagner Siegfried , McKeown Alex , Patel Praveen , Keane Pearse , Fu Dun Jack
Published: January 2022

Objective: Predict visual function with machine-learning applied to automatically acquired quantitative imaging biomarkers in geographic atrophyDesign: Post-hoc analysis of data from a clinical trial and routine clinical care.Methods: Automated segmentation of OCT scans from 476 eyes (325 patients) with geographic atrophy. Machine learning modelling of resultant quantitative OCT (qOCT) biomarkers to predict cross-sectional visual acuity under both standard luminance (VA) and low luminance (LLVA) conditions.Main Outcome Measure: Correlation coefficient (R2) and mean absolute error (MAE) for cross-sectional VA and LLVA in Early Treatment Diabetic Retinopathy Study (ETDRS) letters.Results: Best-corrected VA under both standard luminance (R2 0.46 MAE 10.2 ETDRS letters) and low-luminance conditions (R2 0.25 MAE 12.1) could be predicted. The foveal region contributed the most (46.5%) toward model performance, with retinal pigment epithelium loss and outer retinal atrophy contributing the most (31.1%). For LLVA, however, features in the non-foveal regions were most important (74.5%), led by photoreceptor degeneration (38.9%).Conclusions: Our method of automatic qOCT segmentation demonstrates functional significance for vision in geographic atrophy, including LLVA. LLVA is itself predictive of geographic atrophy progression, implying that the predictive qOCT biomarkers provided by our model are also prognostic.
Diaphragmatic Compound Muscle Action Potentials Recorded From Over the Sternum and Lateral Chest Wall: a Comparative Study
Authors: Younis Gihan , EL-Sawy Noha , Elnemr Rehab , Madkour Doaa
Published: January 2022

Objectives:To report normative data for diaphragmatic compound muscle action potentials (DCMAPs) recorded from over the sternum and lateral chest wall (LCW).Method:The phrenic nerve of seventy-three healthy subjects was bilaterally stimulated at the posterior border of the sternocleidomastoid muscle. DCMAPs from over the sternum and LCW were recorded (inspiration/expiration). Results: Normative values of sternal and LCW DCMAPs were presented. Significant differences were found between sternal and LCW potentials in the mean latency, amplitude, and area (p<0.001). The duration did not differ between the two sites. Differences were found between inspiration and expiration, right and left sides, and men and women. Regression analysis showed a relation between latency of sternal and LCW potentials and age. Latency (LCW potentials) and amplitude and area (sternal/LCW potentials) were related to gender. Amplitude (LCW potentials/inspiration) and area (sternal potentials/inspiration) were related to chest circumference (p=0.023 and 0.013 respectively). Area (sternal potentials/expiration) was related to the BMI (p=0.019). Conclusions: Our normative values for sternal and LCW DCMAPs are provided. Notable differences in the DCMAPs parameters were detected between the two recording sites, inspiration and expiration, right and left, and men and women. Significance:The technique of phrenic nerve should be standardized.
Slipped Capital Femoral Epiphysis Associated With Hypogonadism: A Case Report And Literature Review
Authors: Kitagawa Sachiko , Wakabayashi Kenjiro , Azuma Yoshiteru , Kurahashi Hirokazu , Takazawa Kei , Kashimada Kenichi , Takagi Junko , Yamamoto Toshiyuki , Akihisa Okumura , Iwayama Hideyuki
Published: January 2022

Background: Slipped capital femoral epiphysis (SCFE) is a displacement of the femoral head epiphysis that is sometimes associated with endocrinopathies. We report the case of a 12-year-old girl with hypergonadotropic hypogonadism (HH) who developed SCFE during growth hormone therapy (GHT). We also performed a systematic review of the cases of SCFE and hypogonadism in the literature. Case presentation: The patient was diagnosed with HH based on the absence of ovaries and a uterus. Her medical history included GHT for 9 years as she was small for gestational age. Chromosomal and genetic analyses revealed no pathogenic abnormalities. Radiographs revealed a left SCFE with a 28.7° posterior tilt angle. GHT was discontinued, and bilateral in situ screw fixation was performed. Sex hormone therapy (SHT) was initiated. Two years later, the patient recovered.Methods: We reviewed the cases of hypogonadism complicated with SCFE. The guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 statement were followed. Case reports of patients were retrieved using PubMed on November 17, 2021.Results: A total of 44 cases of SCFE and hypogonadism were identified, including this case. Endocrinological complications included growth hormone deficiency (n = 18), being overweight (n = 9), and hypothyroidism (n = 25). Hormone replacement was administered before (SHT, n = 6; GHT, n = 12) and after surgery (SHT, n = 21; GHT, n = 11). SCFE surgery was invasive (minimal, n = 19; moderate, n = 10; high, n = 8). Orthopedic complications were observed in four cases. Conclusions: If hypogonadism occurs during GHT, SCFE should be noted. Hypogonadism should be studied to determine the effects of hormonal replacement on SCFE.