bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacovigilance in Pediatric Patients with Epilepsy Using Antiepileptic Drugs
Authors: Kopciuch Dorota , Kus Krzysztof , Fliciński Jędrzej , Steinborn Barbara , Winczewska-Wiktor Anna , Paczkowska Anna , Zaprutko Tomasz , Ratajczak Piotr , Nowakowska Elżbieta
Published: April 2022

Objective: To investigate the occurrence of adverse effects of antiepileptic drugs (AEDs) in pediatric epileptic patients on mono- or polytherapy. Method: We evaluated eighty consecutive patients that met the following inclusion criteria: aged ≤18 years; diagnosed with epilepsy for at least one year; a stable dose of AED for at least three months; verbal consent to participation in the study. Patients were asked if they had experienced any adverse drug reaction (ADR) related to the AED. Afterward, regardless of the answer, they were interviewed based on a detailed semi-structured questionnaire about the presence of ADRs associated with the AED. The data were analyzed regarding the use of monotherapy or polytherapy. Results: Ninety-seven percent of the patients reported having experienced ADRs related to AEDs. The greatest number of seizures affected the group of patients treated with monotherapy (both at baseline and at followup), but the greatest number of ADRs were observed among patients treated with polytherapy. In patients on monotherapy, the most frequent ADRs reported at baseline included fatigue and somnolence, and among patients with polytherapy, it was fatigue and hair loss. Conclusion: Children on polytherapy were significantly more likely to develop ADRs compared to those on monotherapy, but a statistically significant improvement in seizure frequency was also observed in the group of patients on polytherapy. Pharmacovigilance is very important in children with AEDs, so that ADRs can be identified early and managed appropriately.
Evaluating the Dissemination and Implementation of a Community Health Worker-Based Community Wide Campaign to Improve Fruit and Vegetable Intake and Physical Activity among Latinos along the U.S.-Mexico Border
Authors: Yeh Paul Gerardo , Reininger Belinda M. , Mitchell-Bennett Lisa A. , Lee Minjae , Xu Tianlin , Davé Amanda C. , Park Soo Kyung , Ochoa-Del Toro Alma G.
Published: April 2022

This study evaluated the dissemination and implementation of a culturally tailored community-wide campaign (CWC), Tu Salud ¡Si Cuenta! (TSSC), to augment fruit and vegetable (FV) consumption and physical activity (PA) engagement among low-income Latinos of Mexican descent living along the U.S.-Mexico Border in Texas. TSSC used longitudinal community health worker (CHW) home visits as a core vehicle to enact positive change across all socioecological levels to induce behavioral change. TSSC’s reach, effectiveness, adoption, implementation, and maintenance (RE-AIM) was examined. A dietary questionnaire and the Godin-Shepherd Exercise Questionnaire measured program effectiveness on mean daily FV consumption and weekly PA engagement, respectively. Participants were classified based on CHW home visits into “low exposure” (2–3 visits) and “high exposure” (4–5 visits) groups. The TSSC program reached low-income Latinos (n = 5686) across twelve locations. TSSC demonstrated effectiveness as, compared to the low exposure group, the high exposure group had a greater FV intake (mean difference = +0.65 FV servings daily, 95% CI: 0.53–0.77) and an increased PA (mean difference = +185.6 MET-minutes weekly, 95% CI: 105.9–265.4) from baseline to the last follow-up on a multivariable linear regression analysis. Multivariable logistic regression revealed that the high exposure group had higher odds of meeting both FV guidelines (adjusted odds ratio (AOR) = 2.03, 95% CI: 1.65–2.47) and PA guidelines (AOR = 1.36, 95% CI: 1.10–1.68) at the last follow-up. The program had a 92.3% adoption rate, with 58.3% of adopting communities meeting implementation fidelity, and 91.7% of communities maintaining TSSC. TSSC improved FV consumption and PA engagement behaviors among low-income Latinos region wide. CHW delivery and implementation funding positively influenced reach, effectiveness, adoption, and maintenance, while lack of qualified CHWs negatively impacted fidelity.
The Abysmal Organization of Work and Work Safety Culture Experienced by North Carolina Latinx Women in Farmworker Families
Authors: Arcury Thomas A. , Smith Sydney A. , Talton Jennifer W. , Quandt Sara A.
Published: April 2022

The occupational health of immigrant workers in the United States is a major concern. This analysis describes two domains, organization of work and work safety culture, important to the occupational health of Latinx women in farmworker families. Sixty-seven Latinx women in North Carolina farmworker families completed a baseline and five follow-up questionnaires in 2019 through 2021. Fifty-nine of the women were employed in the year prior to the Follow-Up 5 Questionnaire. These women experienced an abysmal organization of work and work safety culture. They experienced significant job churn, with most changing employment several times during the 18-month period. Most of their jobs were seasonal, paid less than $10.00 per hour, piece-rate, and almost all without benefits. The women’s jobs had little skill variety (mean 1.5) or decision latitude (mean 1.1), but had high psychological demands (mean 2.0). Work safety climate was very low (mean 13.7), with 76.3% of women noting that their supervisors were “only interested in doing the job fast and cheaply” rather than safely. Women employed as farmworkers versus those in other jobs had few differences. Further research and intervention are needed on the organization of work and work safety culture of Latinx women manual workers.
Physical Examination Tool for Swollen and Tender Lower Limb Joints in Juvenile Idiopathic Arthritis: A Pilot Diagnostic Accuracy Study
Authors: Fellas Antoni , Singh-Grewal Davinder , Chaitow Jeffrey , Warner Denise , Onikul Ella , Santos Derek , Clapham Matthew , Coda Andrea
Published: April 2022

Background: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children, with lower limb involvement highly prevalent. Recent evidence has highlighted the lack of specific lower limb physical examination (PE) tools for clinicians assisting the paediatric rheumatology team in identifying lower extremity disease in patients with JIA. Early clinical detection may lead to more prompt and targeted interventions to reduce lower limb problems in children with JIA. The aim of this pilot study is to provide preliminary data on the diagnostic accuracy of a lower limb PE tool in JIA. Methods: Children with JIA requiring magnetic resonance imaging (MRI) on their lower limb joints per their usual care were eligible. Lower limb joint counts were conducted clinically by a podiatrist and paediatric rheumatologist using the proposed twenty joint per side, PE tool. The PE were compared to MRI assessments completed by two independent paediatric radiologists. Data were analysed using agreement (observed, positive and negative) and Cohen’s kappa with 95% CIs. Results: Fifteen participants were recruited into the study in which 600 lower limb joints were clinically examined. Statistical analysis showed excellent inter-rater reliability between podiatrist and paediatric rheumatologist for both joint swelling and tenderness. Results of the intra-rater reliability of the podiatrist using the PE tool indicated excellent percentage agreements (98.5–100%) and substantial kappa coefficients (0.93–1). The inter-rater reliability between radiological assessments contrasted the PE results, showing low agreement and poor reliability. Comparisons between PE and MRI resulted in poor kappa coefficients and low agreement percentages. The most agreeable joint between MRI and PE was the ankle joint, while the worst performing joint was the sub-talar joint. Conclusion: Results indicate potential clinical reliability; however, the validity and diagnostic accuracy of the proposed PE tool remains unclear due to low kappa coefficients and inconsistent agreements between PE and MRI results. Further research will be required before the tool may be used in a clinical setting.
Impact of Residential Concentration of PM2.5 Analyzed as Time-Varying Covariate on the Survival Rate of Lung Cancer Patients: A 15-Year Hospital-Based Study in Upper Northern Thailand
Authors: Nakharutai Nawapon , Traisathit Patrinee , Thongsak Natthapat , Supasri Titaporn , Srikummoon Pimwarat , Thumronglaohapun Salinee , Hemwan Phonpat , Chitapanarux Imjai
Published: April 2022

Air pollutants, especially particulate matter (PM) ≤ 2.5 µm (PM2.5) and PM ≤ 10 µm (PM10), are a major concern in upper northern Thailand. Data from a retrospective cohort comprising 9820 lung cancer patients diagnosed from 2003 to 2018 were obtained from the Chiang Mai Cancer Registry, and used to evaluate mortality and survival rates. Cox proportional hazard models were used to identify the association between the risk of death and risk factors including gender, age, cancer stage, smoking history, alcohol-use history, calendar year of enrollment, and time-updated PM2.5, PM10, NO2 and O3 concentrations. The mortality rate was 68.2 per 100 persons per year of follow-up. In a multivariate analysis, gender, age, cancer stage, calendar year of enrollment, and time-varying residential concentration of PM2.5 were independently associated with the risk of death. The lower the annually averaged PM2.5 and PM10 concentrations, the higher the survival probability of the patient. As PM2.5 and PM10 were factors associated with a higher risk of death, lung cancer patients who are inhabitant in the area should reduce their exposure to high concentrations of PM2.5 and PM10 to increase survival rates.
Effects of Biological/Targeted Therapies on Bone Mineral Density in Inflammatory Arthritis
Authors: Chen Tai-Li , Chang Kai-Hung , Su Kuei-Ying
Published: April 2022

Inflammatory arthritis has been reported to be associated with the development of osteoporosis. Recent research has investigated the mechanisms of bone metabolism in chronic inflammatory arthritis such as rheumatoid arthritis (RA) and spondyloarthritis (SpA). Progress in both animal and clinical studies has provided a better understanding of the osteoclastogenesis-related pathways regarding the receptor activator of nuclear factor-κB ligand (RANKL), anti-citrullinated protein antibodies (ACPAs), and Wnt signaling and Dickkopf-related protein 1 (Dkk-1). The complex interplay between inflammatory cytokines and bone destruction has been elucidated, especially that in the interleukin-17/23 (IL-17/23) axis and Janus kinase and signal transducer and activator of transcription (JAK-STAT) signaling. Moreover, advances in biological and targeted therapies have achieved essential modifications to the bone metabolism of these inflammatory arthritis types. In this narrative review, we discuss recent findings on the pathogenic effects on bone in RA and SpA. Proinflammatory cytokines, autoantibodies, and multiple signaling pathways play an essential role in bone destruction in RA and SpA patients. We also reviewed the underlying pathomechanisms of bone structure in biological and targeted therapies of RA and SpA. The clinical implications of tumor necrosis factor inhibitors, abatacept, rituximab, tocilizumab, Janus kinase inhibitors, and inhibitors of the IL-17/23 axis are discussed. Since these novel therapeutics provide new options for disease improvement and symptom control in patients with RA and SpA, further rigorous evidence is warranted to provide a clinical reference for physicians and patients.
CD40–CD40L in Neurological Disease
Authors: Ots Heather D. , Tracz Jovanna A. , Vinokuroff Katherine E. , Musto Alberto E.
Published: April 2022

Immune-inflammatory conditions in the central nervous system (CNS) rely on molecular and cellular interactions which are homeostatically maintained to protect neural tissue from harm. The CD40–CD40L interaction upregulates key proinflammatory molecules, a function best understood in the context of infection, during which B-cells are activated via CD40 signaling to produce antibodies. However, the role of CD40 in neurological disease of non-infectious etiology is unclear. We review the role of CD40–CD40L in traumatic brain injury, Alzheimer’s Disease, Parkinson’s Disease, stroke, epilepsy, nerve injury, multiple sclerosis, ALS, myasthenia gravis and brain tumors. We also highlight therapeutic advancements targeting the CD40 system to either attenuate the neuroinflammatory response or leverage the downstream effects of CD40 signaling for direct tumor cell lysis.
Mechanisms of Resistance to Photodynamic Therapy (PDT) in Vulvar Cancer
Authors: Mossakowska Beata Joanna , Shahmoradi Ghahe Somayeh , Cysewski Dominik , Fabisiewicz Anna , Tudek Barbara , Siedlecki Janusz Aleksander
Published: April 2022

Photodynamic therapy (PDT) is a valuable treatment method for vulvar intraepithelial neoplasia (VIN). It allows for the treatment of a multifocal disease with minimal tissue destruction. 5-Aminolevulinic acid (5-ALA) is the most commonly used prodrug, which is converted in the heme pathway to protoporphyrin IX (PpIX), an actual photosensitizer (PS). Unfortunately, not all patients treated with PDT undergo complete remission. The main cause of their failure is resistance to anticancer therapy. In many cancers, resistance to various anticancer treatments is correlated with increased activity of the DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1). Enhanced activity of drug pumps may also affect the effectiveness of therapy. To investigate whether multidrug resistance mechanisms underlie PDT resistance in VIN, porphyrins were isolated from sensitive and resistant vulvar cancer cells and their culture media. APE1 activity was measured, and survival assay after PDT combined with APE1 inhibitor was performed. Our results revealed that resistant cells accumulated and effluxed less porphyrins than sensitive cells, and in response to PDT, resistant cells increased APE1 activity. Moreover, PDT combined with inhibition of APE1 significantly decreased the survival of PDT-resistant cells. This means that resistance to PDT in vulvar cancer may be the result of alterations in the heme synthesis pathway. Moreover, increased APE1 activity may be essential for the repair of PDT-mediated DNA damage, and inhibition of APE1 activity may increase the efficacy of PDT.
Applications of Plasma-Activated Water in Dentistry: A Review
Authors: Milhan Noala Vicensoto Moreira , Chiappim William , Sampaio Aline da Graça , Vegian Mariana Raquel da Cruz , Pessoa Rodrigo Sávio , Koga-Ito Cristiane Yumi
Published: April 2022

The activation of water by non-thermal plasma creates a liquid with active constituents referred to as plasma-activated water (PAW). Due to its active constituents, PAW may play an important role in different fields, such as agriculture, the food industry and healthcare. Plasma liquid technology has received attention in recent years due to its versatility and good potential, mainly focused on different health care purposes. This interest has extended to dentistry, since the use of a plasma–liquid technology could bring clinical advantages, compared to direct application of non-thermal atmospheric pressure plasmas (NTAPPs). The aim of this paper is to discuss the applicability of PAW in different areas of dentistry, according to the published literature about NTAPPs and plasma–liquid technology. The direct and indirect application of NTAPPs are presented in the introduction. Posteriorly, the main reactors for generating PAW and its active constituents with a role in biomedical applications are specified, followed by a section that discusses, in detail, the use of PAW as a tool for different oral diseases.
A Narrative Review: Gingival Stem Cells as a Limitless Reservoir for Regenerative Medicine
Authors: Fonticoli Luigia , Della Rocca Ylenia , Rajan Thangavelu Soundara , Murmura Giovanna , Trubiani Oriana , Oliva Stefano , Pizzicannella Jacopo , Marconi Guya Diletta , Diomede Francesca
Published: April 2022

The gingival tissue can be collected in an easy way and represent an accessible source to isolate gingival-derived mesenchymal stem cells (GMSCs). GMSCs are a subpopulation of dental-derived mesenchymal stem cells that show the mesenchymal stem cells (MSCs) features, such as differentiation abilities and immunomodulatory properties. Dental-derived stem cells are also expandable in vitro with genomic stability and the possibility to maintain the stemness properties over a prolonged period of passages. Moreover, several preclinical studies have documented that the extracellular vesicles (EVs) released from GMSCs possess similar biological functions and therapeutic effects. The EVs may represent a promising tool in the cell-free regenerative therapy approach. The present review paper summarized the GMSCs, their multi-lineage differentiation capacities, immunomodulatory features, and the potential use in the treatment of several diseases in order to stimulate tissue regeneration. GMSCs should be considered a good stem cell source for potential applications in tissue engineering and regenerative dentistry.
The ATX–LPA Axis Regulates Vascular Permeability during Cerebral Ischemic-Reperfusion
Authors: Bhattarai Susmita , Sharma Sudha , Subedi Utsab , Ara Hosne , Shum Alika , Milena Murov , Bhuiyan Md. Shenuarin , Kidambi Srivatsan , Sun Hong , Miriyala Sumitra , Panchatcharam Manikandan
Published: April 2022

Endothelial permeability is a major complication that must be addressed during stroke treatment. Study of the mechanisms underlying blood–brain barrier (BBB) disruption and management of the hypoxic stress-induced permeability of the endothelium following reperfusion are both urgently needed for stroke management. Lysophosphatidic acid (LPA), a bioactive lipid essential for basic cellular functions, causes unfavorable outcomes during stroke progression. LPA-producing enzyme autotaxin (ATX) is regulated in ischemic stroke. We used an electrical cell-substrate impedance sensor (ECIS) to measure endothelial permeability. Mitochondrial bioenergetics were obtained using a Seahorse analyzer. AR-2 probe fluorescence assay was used to measure ATX activity. LPA increased endothelial permeability and reduced junctional protein expression in mouse brain microvascular endothelial cells (MBMEC). LPA receptor inhibitors Ki16425 and AM095 attenuated the LPA-induced changes in the endothelial permeability and junctional proteins. LPA significantly diminished mitochondrial function in MBMEC. ATX was upregulated (p < 0.05) in brain microvascular endothelial cells under hypoxic reperfusion. ATX activity and permeability were attenuated with the use of an ATX inhibitor in a mouse stroke model. The upregulation of ATX with hypoxic reperfusion leads to LPA production in brain endothelial cells favoring permeability. Inhibition of the ATX–LPA–LPAR axis could be therapeutically targeted in stroke to achieve better outcomes.
ClPIF3-ClHY5 Module Regulates ClPSY1 to Promote Watermelon Fruit Lycopene Accumulation Earlier under Supplementary Red Lighting
Authors: Lv Tinghui , Zhao Lili , Zhang Shuting , Guan Jingyue , Liu Wei , Qi Hongyan
Published: April 2022

Lycopene content is one of the important factors for determining watermelon fruit quality. In this study, a small-type watermelon was grown in a greenhouse with supplementary red lighting for 10 h per day. The results showed that the content of lycopene in the flesh was increased 6.3-fold after 25 days of supplementary red lighting. qRT-PCR analysis showed that PHYTOENE SYNTHASE 1(ClPSY1) is the major gene that responds to red light within the lycopene synthesis pathway. Moreover, we identified two key transcription factors that were involved in light signal transduction PHYTOCHROME INTERACTING FACTORS 3 (ClPIF3) and LONG HYPOCOTYL 5 (ClHY5) in watermelon flesh. The interaction experiments showed that ClHY5, a potent ClPIF3 antagonist, regulated ClPSY1 expression by directly targeting a common promoter cis-element (G-box). Collectively, our findings identified that ClHY5 and ClPIF3 formed an activation-suppression transcriptional module that is responsive to red light and, through this model, regulated watermelon lycopene accumulation in greenhouse winter cultivation.
Activation of TRPV4 Induces Exocytosis and Ferroptosis in Human Melanoma Cells
Authors: Li Mei , Zheng Jiaojiao , Wu Tian , He Yulin , Guo Jing , Xu Jiao , Gao Chuanzhou , Qu Shuxian , Zhang Qianyi , Zhao Jiayu , Cheng Wei
Published: April 2022

TRPV4 (transient receptor potential vanilloid 4), a calcium permeable TRP ion channel, is known to play a key role in endocytosis. However, whether it contributes to exocytosis remains unclear. Here, we report that activation of TRPV4 induced massive exocytosis in both melanoma A375 cell and heterologous expression systems. We show here that, upon application of TRPV4-specific agonists, prominent vesicle priming from endoplasmic reticulum (ER) was observed, followed by morphological changes of mitochondrial crista may lead to cell ferroptosis. We further identified interactions between TRPV4 and folding/vesicle trafficking proteins, which were triggered by calcium entry through activated TRPV4. This interplay, in turn, enhanced TRPV4-mediated activation of folding and vesicle trafficking proteins to promote exocytosis. Our study revealed a signaling mechanism underlying stimulus-triggered exocytosis in melanoma and highlighted the role of cellular sensor TRPV4 ion channel in mediating ferroptosis.
Recommendation System Algorithms on Location-Based Social Networks: Comparative Study
Authors: Al-Nafjan Abeer , Alrashoudi Norah , Alrasheed Hend
Published: April 2022

Currently, social networks allow individuals from all over the world to share ideas, activities, events, and interests over the Internet. Using location-based social networks (LBSNs), users can share their locations and location-related content, including images and reviews. Location rec-14 recommendation system-based LBSN has gained considerable attention in research using techniques and methods based on users’ geosocial activities. In this study, we present a comparative analysis of three matrix factorization (MF) algorithms, namely, singular value decomposition (SVD), singular value decomposition plus (SVD++), and nonnegative matrix factorization (NMF). The primary task of the implemented recommender system was to predict restaurant ratings for each user and make a recommendation based on this prediction. This experiment used two performance metrics for evaluation, namely, root mean square error (RMSE) and mean absolute error (MAE). The RMSEs confirmed the efficacy of SVD with a lower error rate, whereas SVD++ had a lower error rate in terms of MAE.
A Feasibility Study of Two Cognitive Training Programs for Urban Community-Dwelling Older Adults
Authors: Benham Sara , Otchet Kelly , Senft Diana , Potter Ann Marie
Published: April 2022

Cognitive training approaches are promising to manage the effects of normal cognitive decline for the aging adult, especially with the development and integration of computerized cognitive training. Supportive community models for older adults, such as senior centers, may provide engagement opportunities for occupation-based cognitive training programming. Fourteen older adults (n = 13 Black) from an urban older adult community center participated. This feasibility trial used a two-group, pretest-posttest design to examine differences between an occupation-based computerized cognitive training (CCT) program (n = 7) and a traditional cognitive training (TCT) program (n = 7), as assessed by participants’ perceptions of the perceived benefits, tolerance of time of sessions, and on executive functioning measures. There were no significant differences in the tolerance of time of sessions (p = 0.81) between CCT (average session time = 43.64 min) and TCT (average session time = 44.27 min). Additionally, there were no significant differences in how the two program groups perceived the training based on helpfulness (p = 1.00), positive opinions (p = 0.46), and executive functioning measurement changes. All participants reported “enjoyment” of the training. Including occupation-based CCT and TCT programming is feasible and positive within community-based programming focusing on a diverse population. Short-term improvements in executive functioning should not be expected but are worthy of longer-term observation, considering a socialization component, telehealth integrations, and expansion of supportive technology-based models.
Short- and Long-Term Visual Outcomes in Patients Receiving Intravitreal Injections: The Impact of the Coronavirus 2019 Disease (COVID-19)—Related Lockdown
Authors: Douglas Vivian Paraskevi , Douglas Konstantinos A. A. , Vavvas Demetrios G. , Miller Joan W. , Miller John B.
Published: April 2022

Purpose: To investigate the short- and long-term impact of COVID-19—related lockdown on the vision of patients requiring intravitreal injections (IVI) for neovascular Age-related Macular degeneration (nvAMD), diabetic retinopathy (DR), central retinal vein occlusion (CRVO), or branch retinal vein occlusion (BRVO). Methods: This is a retrospective study from the Retina department of three Mass Eye and Ear centers. Charts of patients age of ≥ 18 years with any of the abovementioned diagnoses who had a scheduled appointment anytime between 17 March 2020 until 18 May 2020 (lockdown period in Boston, Massachusetts) were reviewed at baseline (up to 12 weeks before the lockdown), at first available follow-up (=actual f/u) during or after the lockdown period, at 3 months, 6 months, and at last available completed appointment of 2020. Results: A total of 1001 patients met the inclusion criteria. Of those patients, 479 (47.9%) completed their intended f/u appointment, while 522 missed it (canceled and “no show”). The delay in care of those who missed it was 59.15 days [standard deviation (SD) ± 49.6]. In these patients, significant loss of vision was noted at actual f/u [Best corrected visual acuity (BCVA) in LogMAR (Logarithm of the Minimum Angle of Resolution)—mean (±SD)—completed: 0.45 (±0.46), missed: 0.53 (±0.55); p = 0.01], which was more prominent in the DR group [Visual acuity (VA) change in LogMAR—mean (±SD); completed: 0.04 (±0.28), missed: 0.18 (±0.44); p = 0.02] and CRVO [completed: −0.06 (±0.27), missed: 0.11 (±0.35); p = <0.001] groups followed by nvAMD [completed: 0.006 (±0.16), missed: 0.06 (±0.27); p = 0.004] and BRVO [completed: −0.02 (±0.1), missed: 0.03 (±0.14); p = 0.02] ones. Overall, a higher percent of people who missed their intended f/u experienced vision loss of more than 15 letters at last f/u compared to those who completed it [missed vs. completed; 13.4% vs. 7.4% in nvAMD (p = 0.72), 7.8% vs. 6.3% in DR (0.84), 15.5% vs. 9.9% in CRVO (p < 0.001) and 9.6% vs. 2% in BRVO (p = 0.48)]. Conclusions: Delay in care of about 8.45 weeks can lead to loss of vision in patients who receive IVI with DR and CRVO patients being more vulnerable in the short-term, whereas in the long-term, CRVO patients followed by the nvAMD patients demonstrating the least vision recovery. BRVO patients were less likely to be affected by the delay in care. Adherence to treatment is key for maintaining and improving visual outcomes in patients who require IVI.
Development of In-Process Temperature Measurement of Grinding Surface with an Infrared Thermometer
Authors: Ito Yukio , Kita Yoshiyuki , Fukuhara Yoshiya , Nomura Mamoru , Sasahara Hiroyuki
Published: April 2022

Heat generation is a critical issue in grinding. If the grinding point generates significant heat, dimensional and shape accuracy may decrease due to thermal deformation, and the machined surface may deteriorate due to grinding burn. Therefore, monitoring the temperature during grinding is important to obtain ideal machining results. In this research, we develop a new method to measure the grinding surface and grinding wheel surface temperature during in-process machining. The proposed method measures the temperature of the grinding surface through small holes in a rotating grinding wheel. Using this method, we measured the temperature of the grinding surface during the dry grinding of carbon fiber reinforced plastics (CFRP). Temperature of the grinding surface was measured every 1/4 rotation of the grinding wheel at any depth of cut, assuming precision grinding, rough grinding, and high-efficiency grinding. The measurement value changed depending on the temperature measurement position of the infrared thermometer from numerical analysis of the grinding surface temperature. We also found that when the cut depth was small, the temperature, including the surface of the workpiece before machining, was measured at a specific temperature measurement position. The newly developed temperature measurement method was capable of in-process measurement of the grinding surface temperature and of detecting temperature rise when the grinding wheel was clogged.
Many-Objective Container Stowage Optimization Based on Improved NSGA-III
Authors: Wang Yuchuang , Shi Guoyou , Hirayama Katsutoshi
Published: April 2022

The container ship stowage planning problem (CSPP) is a very complex and challenging issue concerning the interests of shipping companies and ports. This article has developed a many-objective CSPP solution that optimizes ship stability and reduces the number of shifts over the whole route while at the same time considering realistic constraints such as the physical structure of the ship and the layout of the container yard. Use the initial metacentric height (GM) along with the ship’s heeling angle and trim to measure its stability. Meanwhile, use the total amount of relocation in the container terminal yard, the voluntary shift in the container ship’s bay, and the necessary shift of the future unloading port to measure the number of shifts on the whole route. This article proposes a variant of the nondominated sorting genetic algorithm III (NSGA-III) combined with local search components to solve this problem. The algorithm can produce a set of non-dominated solutions, then decision-makers can choose the best practical implementation based on their experience and preferences. After carrying out a large number of experiments on 48 examples, our calculation results show that the algorithm is effective compared with NSGA-II and random weighted genetic algorithms, especially when applied to solve many-objective CSPPs.
The Impact of Investment Efficiency on Firm Value and Moderating Role of Institutional Ownership and Board Independence
Authors: Salehi Mahdi , Zimon Grzegorz , Arianpoor Arash , Gholezoo Fatemeh Eidi
Published: April 2022

This study investigates the impact of investment efficiency on firm value with a moderating role of institutional ownership and board independence for companies listed on the Tehran Stock Exchange (TSE). The information from 177 companies in 2014–2021 was examined. Tobin’s Q is a common measure for firm value, and it is a market-based measure and provides a good tool of comparison. The results show that investment efficiency has an impact on firm value. In addition, institutional ownership and board independence moderate this impact. There is a gap between the impact of investment efficiency on firm value and the moderating role of institutional ownership and board independence. This gap creates an opportunity for carrying out in-depth research on those variables. Since the impact of investment efficiency on firm value emphasizing the role of institutional ownership and board independence has not been studied, the study’s findings can show the importance and necessity of this study and fill the gap in this field.
Bio-Priming with Compatible Rhizospheric Microbes Enhances Growth and Micronutrient Uptake of Red Cabbage
Authors: Sarkar Deepranjan , Rakshit Amitava , Parewa Hanuman Prasad , Danish Subhan , Alfarraj Saleh , Datta Rahul
Published: April 2022

Red cabbage is known as the millennium’s functional food, which has a lot of importance in our diet because of the health-promoting ingredients present in it. The current study investigated the synergistic relationship of rhizospheric-competent microbial agents (Trichoderma harzianum, Pseudomonas fluorescens, and Bacillus subtilis) in modulating the performance of red cabbage under the field conditions of Middle Gangetic Plains, India. Growth parameters were studied at three developmental stages, viz., pre-cupping, early head formation, and maturity. Our results suggested that the dual application of T. harzianum + P. fluorescens along with the 75% recommended dose of fertilizers (RDF) increased the number of leaves (24.6), leaf area (537.2 cm2), root length (19.8 cm), and micronutrient uptake (Fe, Mn, and Cu) by head of the crop, whereas the co-inoculation of P. fluorescens and B. subtilis along with 75% RDF enhanced plant spread (39.0 cm), earliness (95.2 days), and Zn uptake. Maximum plant height (28.7 cm) and chlorophyll (SPAD, 77.3) were recorded in 100% RDF (120:60:60 kg ha−1) and the combination of T. harzianum + B. subtilis along with 75% RDF, respectively. Interestingly, consortium (T. harzianum + P. fluorescens) bio-primed plants recorded about 14% higher root length in comparison to plants receiving sole fertilizers. The regression analysis revealed a significant relationship of Fe and Mn uptake with chlorophyll (SPAD) and between Zn uptake and the earliness of the crop. The present study indicated that seedling bio-priming with the dual consortium of efficient bio-agents is a viable strategy to lessen our dependence on chemical fertilizers for improving red cabbage production.
Financial Exclusion in Rural and Urban Contexts in Poland: A Threat to Achieving SDG Eight?
Authors: Náñez Alonso Sergio Luis , Jorge-Vazquez Javier , Echarte Fernández Miguel Ángel , Kolegowicz Konrad , Szymla Wojciech
Published: April 2022

Financial inclusion, which consists of having a financial system that is easily accessible to citizens, is identified by various international organizations such as the new UN Agenda 2030, as a priority objective. This objective is particularly relevant in rural areas, where access to these services is more difficult, as citizens have to travel several kilometers to access them. In this study, we analyze the current situation of the Polish financial sector in terms of its accessibility, in order to measure the degree of financial inclusion. For this purpose, we use three combined methodologies. Initially, a data extraction from the Central Bank of Poland was carried out. Subsequently, three methodologies are applied to calculate financial inclusion. First, we apply the criteria of the Financial Access Survey (FAS) of the International Monetary Fund. Secondly, the Access to Cash Index (ACI) methodology by calculating a score that describes the access to banking services according to certain items. Finally, we applied the nearest neighbor methodology to detect in each voivodship those points where it is most difficult (measured in km distance) to access banking services. Some areas, especially in rural areas of the different voivodeships, present certain problems when it comes to accessing banking services. Therefore, the fulfillment of SDG 8.10 will be more difficult to achieve in these areas. The public authorities must pay attention to this, in order to reach the commitments acquired with the 2030 agenda, in terms of financial inclusion.
The Form and Formation of Constitutionalism in India
Authors: Babie Paul T. , Bhanu Arvind P.
Published: April 2022

To allow for the effective functioning of a state, measures are necessary to limit the power of government, securing to the people certain fundamental human rights. These limitations are frequently referred to as ‘constitutionalism’. This essay explores the nature of constitutionalism found in India, and specifically as it has evolved through judicial interpretation—the process whereby judicial decisions have given meaning and content to the written constitution. In this way, the judiciary has balanced the power of government with the rights of the people. Constitutionalism is indispensable to effective governance, balancing power with right.
Simulation of the Fatigue Crack Initiation in SAE 52100 Martensitic Hardened Bearing Steel during Rolling Contact
Authors: Dogahe Kiarash Jamali , Guski Vinzenz , Mlikota Marijo , Schmauder Siegfried , Holweger Walter , Spille Joshua , Mayer Joachim , Schwedt Alexander , Görlach Bernd , Wranik Jürgen
Published: April 2022

An investigation on the White Etching Crack (WEC) phenomenon as a severe damage mode in bearing applications led to the observation that in a latent pre-damage state period, visible alterations appear on the surface of the raceway. A detailed inspection of the microstructure underneath the alterations reveals the existence of plenty of nano-sized pores in a depth range of 80 µm to 200 µm. The depth of the maximum Hertzian stress is calculated to be at 127 µm subsurface. The present study investigates the effect of these nanopores on the fatigue crack initiation in SAE 52100 martensitic hardened bearing steel. In this sense, two micro-models by means of the Finite Element Method (FEM) are developed for both a sample with and a sample without pores. The number of cycles required for the crack initiation for both samples is calculated, using the physical-based Tanaka–Mura model. It is shown that pores reduce the number of cycles in bearing application to come to an earlier transition from microstructural short cracks (MSC) to long crack (LC) propagation significantly.
Adsorption of Sodium Diclofenac in Functionalized Palygoskite Clays
Authors: Sousa Matheus Urtiga , Rodrigues Alisson Mendes , Araujo Maria Eduarda Barbosa , Menezes Romualdo Rodrigues , Neves Gelmires Araújo , Lira Hélio Lucena
Published: April 2022

The effects of acid and organo-functionalizations on the surface of Brazilian palygorskite clay was investigated, evaluating its potential in the adsorptive capacity of the drug sodium diclofenac present in wastewaters. The modifications on the clay structure were investigated by X-ray diffraction, X-ray fluorescence, thermogravimetric, differential thermal analysis, Fourier transform infrared spectroscopy, surface area by N2 adsorption (77.5 K) and Zeta potential. The experimental design was carried out to find the best conditions for the adsorption tests, in which concentration, mass and pH were significant. In the kinetic study, the pseudo-second-order model better described the adsorption process for acid and organo-functionalized samples. Such results indicate that the adsorption behavior probably occurs due to the phenomenon of chemisorption. Regarding the adsorption isotherms, the Langmuir model was the one that best adjusted both the experimental data of acid and the organo-functionalized samples, whose maximum adsorption capacity were 179.88 and 253.34 mg/g, respectively. This model also indicates that the sodium diclofenac is adsorbed to monolayers homogeneously through chemisorption. In general, the studied clays proved to be suitable adsorbents for the removal of sodium diclofenac.
Influence of Different Parameters on the Performance of Alkali-Activated Slag/Fly Ash Composite System
Authors: Zhang Zhipeng , Jia Yanmin , Liu Jinliang
Published: April 2022

In order to study the influence law of each parameter on the performance of the alkali-activated composite gelling system, the influence degree was sorted, and the most important parameter affecting each performance was found. The solution of liquid water glass and solid sodium hydroxide was used as the alkaline activator, and the mixing ratio was designed by the orthogonal test method. The effects of four parameters of fly ash content, water glass modulus, water glass solid content, and water–solid ratio on the working performance and mechanical properties of alkali-activated slag–fly ash composite cementation system were discussed. The gelling system was studied by microscopic experiments such as SEM and FTIR. The results show that the solid content of water glass has the greatest influence on the fluidity of the composite cementitious system, and the content of fly ash is the primary factor affecting the setting time of the material. The flexural and compressive strengths at the age of 7 d and 28 d were most affected by the content of fly ash, and the solid content of water glass had the greatest influence on the flexural and compressive strengths at the age of 2 d. From the perspective of microscopic morphology, in the high-strength samples, the fly ash particles and the remaining outer shell are embedded in the gel to form a dense whole. When the amount of silica in the composite gelling system is too high, it will cause the phenomenon of low macroscopic mechanical properties.
Hardening of Nanoporous Au Induced by Exposure to Different Gaseous Environments
Authors: Pia Giorgio , Sogne Elisa , Falqui Andrea , Delogu Francesco
Published: April 2022

This work focuses on the mechanical behaviour of nanoporous Au samples alternately exposed to ozone and carbon dioxide. Nanoporous Au was fabricated by freely corroding the Ag70Au30 parent alloys prepared by mechanical alloying in the form of powder and subsequently compacted by cold pressing. Dealloying was performed in acidic solution, and conditions were suitably adjusted to obtain fine nanoporous Au structures with ligaments about 15 nm thick. Nanoporous Au samples with increasingly thicker ligaments, up to about 40 nm, were fabricated by annealing the pristine nanoporous Au structure for different time intervals at 473 K. For all of the samples, the cyclic variation of gaseous atmosphere results in a macroscopic strain variation due to the occurrence of surface oxidation and reduction processes. We show that the reiterated cyclic exposure to the different gases also induces the progressive hardening of nanoporous Au, which can be ascribed to irreversible strain contributions. For nanoporous Au samples with ligaments that are 15 nm thick, after 50 exposure cycles, the yield strength increases approximately from 49 MPa to 57 MPa. A systematic investigation on coarser nanoporous Au structures indicates that, with the same exposure cycles, the degree of hardening decreases with the ligament thickness.
The Effects of the Mechanical Properties of Vascular Grafts and an Anisotropic Hyperelastic Aortic Model on Local Hemodynamics during Modified Blalock–Taussig Shunt Operation, Assessed Using FSI Simulation
Authors: Kuchumov Alex G. , Khairulin Aleksandr , Shmurak Marina , Porodikov Artem , Merzlyakov Andrey
Published: April 2022

Cardiovascular surgery requires the use of state-of-the-art artificial materials. For example, microporous polytetrafluoroethylene grafts manufactured by Gore-Tex® are used for the treatment of cyanotic heart defects (i.e., modified Blalock–Taussig shunt). Significant mortality during this palliative operation has led surgeons to adopt mathematical models to eliminate complications by performing fluid–solid interaction (FSI) simulations. To proceed with FSI modeling, it is necessary to know either the mechanical properties of the aorta and graft or the rheological properties of blood. The properties of the aorta and blood can be found in the literature, but there are no data about the mechanical properties of Gore-Tex® grafts. Experimental studies were carried out on the mechanical properties vascular grafts adopted for modified pediatric Blalock–Taussig shunts. Parameters of two models (the five-parameter Mooney–Rivlin model and the three-parameter Yeoh model) were determined by uniaxial experimental curve fitting. The obtained data were used for patient-specific FSI modeling of local blood flow in the “aorta-modified Blalock–Taussig shunt–pulmonary artery” system in three different shunt locations: central, right, and left. The anisotropic model of the aortic material showed higher stress values at the peak moment of systole, which may be a key factor determining the strength characteristics of the aorta and pulmonary artery. Additionally, this mechanical parameter is important when installing a central shunt, since it is in the area of the central anastomosis that an increase in stress on the aortic wall is observed. According to computations, the anisotropic model shows smaller values for the displacements of both the aorta and the shunt, which in turn may affect the success of preoperative predictions. Thus, it can be concluded that the anisotropic properties of the aorta play an important role in preoperative modeling.
Load-Carrying Capacity of Double-Shear Bolted Connections with Slotted-In Steel Plates in Squared and Round Timber Based on the Experimental Testing, European Yield Model, and Linear Elastic Fracture Mechanics
Authors: Dobes Pavel , Lokaj Antonin , Mikolasek David
Published: April 2022

Nowadays, the use of timber as a building material is gaining more prominence. When designing timber structures, it is necessary to pay increased attention to the design of their connections. The commonly used connections are dowel-type connections, which are often used in combination with steel plates slotted into cut-outs in timber members. The presented paper deals with the behavior of double-shear bolted connections of squared timber and round timber with slotted-in steel plates. Several variants of connections with different distances between the fastener and the loaded end were selected for the experimental testing. A total of six types of test specimens were made from spruce timber, for which their selected physical properties were determined and evaluated before the experimental testing. Test specimens of bolted connections were first tested in tension parallel to the grain until failure under quasi-static loading. The connections were broken by splitting. Ductile failure preceded brittle failure. The actual load-carrying capacities were lowest for the lowest end distance. The load-carrying capacities for the middle and the longest end distances were comparable. The results of the experiments were then used for comparison with calculation procedures according to the standard for the design of timber structures and with calculations according to the theory of linear elastic fracture mechanics. The experiments and the analytical models were supported by a simple numerical analysis based on the finite element method.
Wavelet-Based Transmissibility for Structural Damage Detection
Authors: Dziedziech Kajetan , Staszewski Wiesław Jerzy , Mendrok Krzysztof , Basu Biswajit
Published: April 2022

Short-time, abrupt events—such as earthquakes and other shock loadings—often lead to damage that is difficult to detect in structures using output-only vibration measurements. The time-variant transmissibility is proposed to tackle this problem. The approach is based on two-dimensional wavelet power spectra. The time-frequency transmissibility and relevant coherence function are used for structural damage detection in structural elements in buildings. Numerical simulations and experimental tests are used in these investigations. The results are compared with the classical transmissibility and time-variant input-output wavelet approach. The paper shows that output-only measurements and wavelet-based transmissibility can be used to monitor abrupt damage-related changes to structural dynamics.