bluuebunny/crossref_metadata_2025 huggingface dataset:
Intelligent complex for modeling safety movement of a multi-agent group of marine robots in uncertain environments
Authors: Maevskiy AM , Kozhemyakin IV , Zanin VU
Published: May 2024

Intensive development today is observed in the areas of data processing and analysis, as well as in the management of robotic systems; Artificial Intelligence (AI) systems are increasingly used. As the complexity of the tasks facing the Marine Robotic Complex (MRC) increases, the need for the use of AI technologies becomes clear. These technologies provide safe movement and control of marine objects, navigation of MRC in maritime space, development of behavior logic in unknown environments and planning of their movement, as well as optimization of data processing. The development of MRC currently covers various areas for which there is no single solution yet. This article outlines the development process of a simulation complex designed to model an intelligent system (IS) for strategizing the motion of a collective of marine robotic systems. It includes an in-depth exposition of individual modules and the mathematical modeling of the employed algorithms.
The association between tumor microenvironment collagen and liver metastasis in colorectal cancer
Authors: Jiawen Fan , Qing Zhu , Jianming Nie , J Dinghua Yang
Published: May 2024

The colon is an organ rich in collagen, while the liver is an organ deficient in collagen. The tissue microenvironment of the two organs differs significantly, but the incidence of liver metastasis in colorectal cancer is high. Besides vascular drainage factors, the changes in collagen occurring in the liver during the process of colorectal cancer liver metastasis are also very important. This article aims to discuss the characteristics of collagen changes in the premetastatic stage, liver colonization, and intrahepatic metastasis process of colorectal cancer liver metastasis.
Phytopathogenic hyphomycetes determined in Yedigöller National Park, Bolu Province
Authors: Doğan Gökhan , Erdoğdu Makbule , Aytaç Zeki , Karayel Ali İhsan , Ertuğrul Tuğba , Suludere Zekiye
Published: May 2024

Sixteen cercosporoid and ramularioid species belonging to nine genera are reported from Yedigöller National Park, Bolu Province, Türkiye. The species were identified based on conventional methods. Of these, Cercospora datiscicola, Cercospora mercurialis, Filiella pastinacae, Pseudocercospora sambucigena, Ramularia linaria, and Ramularia sphaeroidea are new records for Türkiye mycobiota. The description of the new recorded species are presented and discussed with their macro and micromorphological photographs.
A study on the adequacy of gathering areas as urban spaces
Authors: Onay Büşra
Published: May 2024

Türkiye is located in a geography of the world that can be classified as a “high risk” in terms of earthquakes. During and after an earthquake, people feel the need to leave the structures they are in and reach open areas to protect themselves and feel safe. In addition to contributing to the city in a social, psychological, economic and aesthetic sense, these areas should be increased in number and quality, as they are used in accordance with the needs of people for the purpose of escaping from the earthquake disaster, shelter, housing. The open areas scattered throughout the city have been designated as disaster and emergency gathering areas according to the fact that they meet some of the standards mentioned in this study. The main question here is whether the urban open and green space system used as ’gathering areas' is in sufficient and appropriate conditions to respond to the needs after the earthquake and shorten the return to normalcy process. This study was designed to raise awareness of students about the use of urban spaces after the earthquake that occurred on February 6, 2023 and to reveal the level of gathering areas around them. Within the scope of the Urban Design course, students who are in different provinces due to online education were asked for information about the closest gathering area to them, including the distance of their places of residence to the gathering areas, the size of the gathering areas and their current use. In this context, the data related to the collection areas were collected from the students and discussed with the relevant literature. As a result, suggestions were made about the issues that should be taken into account when planning and designing the assembly area.
Kuraklık stresine maruz bırakılan doğu kayını (Fagus orientalis Lipsky.) orijinlerinde bazı stres parametrelerinin araştırılması
Authors: Işık Çakmakçı Sümeyra , Güner Sinan
Published: May 2024

İklim değişikliği ile birlikte kuraklığın artması sonucu ormanların olumsuz yönde etkilenmesi beklenmektedir. Ormanları oluşturan fertler arasında kuraklık stresine dayanıklı genleri tespit etmek, kuraklığa karşı dayanıklı türleri geliştirmek ve tolerans mekanizmalarının belirlenmesi gibi çalışmaları yapmak kuraklık tehlikesi karşısında günümüzde bir kat daha önem kazanmıştır. Aynı zamanda orijinlerin kuraklığa karşı toleranslarının karşılaştırılması gelecekteki tohum transferi ve ıslah çalışmaları için de önem arz etmektedir. Bu çalışmada kuraklık stresine maruz bırakılan Doğu kayını (Fagus orientalis Lipsky.) orijinlerinin kuraklık stresine verdiği tepkilerin belirlenmesi hedeflenmiştir. Bolu, İstanbul, Zonguldak ve Giresun orijinli tohumlar 2021 yılında temin edilmiştir. Tohumlar Artvin Çoruh Üniversitesi, Orman Fakültesi Serasında ekilmiş ve çimlendikten sonra 2 yaşına kadar bakımları ve 2023 yılının temmuz ayından itibaren 2 yaşına gelen fidanlara kuraklık stresi uygulamaları yapılmıştır. Fidanlara kuraklık stresi uygulamak için üç farklı sulama rejimi (günde 1 sulanan (kontrol), 2 günde 1 sulanan, hiç sulanmayan) oluşturulmuştur. 15 gün süren ve kuraklık stresi uygulamalarından sonra fidanlardan alınan yaprak numuneleriyle hidrojen peroksit (H2O2) ve lipid peroksidasyonunun son ürünü olan melondialdehit (MDA) analizleri yapılmıştır. Sulama rejimlerine göre gruplandırılan orijinlerin, kuraklık stresine maruz bırakılan gruplarında, kontrol gruplarına kıyasla H2O2 içeriğinin ve MDA seviyesinin arttığı gözlemlenmiştir. Bu artış Giresun ve Bolu orijinlerinde en fazla; Zonguldak ve İstanbul orijinlerinde azdır. Sonuç olarak, kuraklık stresine maruz bırakılan orijinler arasında en toleranslı olanın İstanbul orijini olduğu önerilmektedir.
Bulanık EDAS yöntemi ile tıbbi aromatik bitki işleme tesisi yer seçimi: Artvin örneği
Authors: Küçük Enis , Dinç Ertan , Öztürk Tayfun
Published: May 2024

İklim değişikliği, biyoçeşitlilik ve toprağın iyi yönetilmesi dünyadaki hızlı nüfus artışı ile birlikte kıt olan bu tür kaynakların daha iyi yönetilmesi ve verimli kullanılması gerekliliğinin önemini artırmaktadır. Tıbbı ve aromatik bitkiler de (TAB) bu kaynaklar arasında yer almakta ve ekonomik açıdan da bir katma değer potansiyeli bulunmaktadır. Doğadan doğrudan veya kültür yolu ile üretimi gerçekleştirilen TAB’ların işlenmesi için tesis yeri seçimi önemli bir stratejik karar unsuru olmaktadır ve genel olarak tesis yeri seçimi problemi, işletmelerin veya örgütlerin karşılaştığı en temel stratejik karar verme problemlerinden biri olarak ortaya çıkmaktadır. Çok fazla faktörün minör veya majör etkilerinin bulunduğu bu karmaşık karar verme sürecini çözümlemek için bu çalışmada çok kriterli karar verme yöntemlerinden (ÇKKV) biri olan EDAS (The evaluation based on distance from average solution) metodolojisinin adımları izlenmiştir. Bunun yanı sıra bulanık teorinin belirsizlik ve eksik bilgi ile baş edebilme yeteneğinden faydalanarak (trapezoidal fuzzy numbers – yamuk bulanık sayılar) problemin çözümüne ulaşmada zaman ve kaynak tasarrufu olarak önemli bir avantaj elde edilmiştir. Çözüm sürecinde üç karar verici ve altı alternatif lokasyonu dilsel terimlerle değerlendirerek bir öncelik sıralaması oluşturulmuş ve en uygun konum (A2- Seyitler Yerleşkesi) belirlenmiştir.
Anıtsal yapıların farklı 3D modelleme programları ve ağaç türleri ile uygulanabilirliği
Authors: Çakıroğlu Evren Osman
Published: May 2024

Tarihte önemli olayların ve kahramanlıkların yaşandığı dönemi vurgulamak ve gelecek nesillere hatırlatmak adına anıtsal eserler bulunmaktadır. Bu olayları ve figürleri taş, mozaik, metal, mermer ve ahşap gibi malzemeler ile uygulayarak görsel bir yapı oluşturulmaktadır. Bu çalışmada Kastamonu’nun kahramanlık sembolü olan Şerife Bacı anıtsal heykelinin 3D modelleme ile rölyef analizinin yapılması ve pürüzsüz ahşap tabloların oluşturulması amaçlanmıştır. Çalışmanın başlangıcında Kastamonu’da fotoğraf makinesi ile 20 farklı açıdan fotoğraflama yapılmıştır. Zbrush ve Alphacam modelleme programları kullanılarak CNC makinası ile ahşaba uygulanmıştır. Çalışma kapsamında 2 çeşit 3D modelleme programı ve 3 farklı ağaç türünden yararlanılmıştır. CNC makinası için tüm ağaç türlerinde devir hızı 18000 devir/dk, dalma hızı 4000 mm/dk, kesme hızı 8000 mm/dk olarak belirlenmiştir. Kesici takım çapı 3D işleme için 2mm, kaba işlemeler için 10 mm ve 20 mm olarak seçilmiştir. Kestane, sapelli ve kayın ağaç malzemelerden 50×55 cm tablolar ve sadece kayın ağaç malzemeden 150×200 cm boyutlu ana tablo üretilmeye çalışılmıştır. Sonuçlar, Zbrush ve Alphacam modelleme programlarının birbiri ile uyumlu çalıştığını, büyük boyutlu üretimlerde de kayın türünün bazı çatlama ve yapısal bozukluklara neden olabileceğini göstermiştir. Ağaç malzeme kullanılarak büyük boyutlu 3D model üretilirken, bir bütün halinde değil de parça parça tasarlanıp uygulanabileceği gözlemlenmiştir.
Evaluating the Cumulative Effects of Fundamental Radiation Safety Measures on Health Professionals in Cath Lab
Authors: Nair Sajeesh S , Gupta Saral Kumar , Shine N S , Thomas K T , Bijumon P R , George Stanly , Nair Sarath S , George Anu K
Published: May 2024

Objectives: The significant rise in modern cath lab units has led to a proportionate increase in cath lab procedures and subsequent radiation environment may elevate the occupational radiation exposure to staff. This study aimed to assess the collective impact of fundamental radiation safety devices in the cath lab on decreasing occupational radiation exposure to staff. Methods: This study was conducted in our cath lab room, equipped with a Siemens Artis cath lab unit. Measurements were performed using RaySafe X2 detectors and Thermo Luminescent Dosimeters (TLDs). Dose assessments were conducted without safety measures and then found a considerable reduction of dose by adding basic radiation safety measures. Findings: The use of lead aprons resulted in a substantial reduction( 92%) in radiation dose. The effect of time and distance versus dose was plotted. The impact of lead flaps and the use of a ceiling suspension shield quantify reductions in scattered doses. The cumulative impact of each safety measure was calculated, and the outcome indicates a 99% reduction in dose. The importance of utilizing all available protective measures when working with radiation cannot be overstated. It is essential for maximizing safety, minimizing risks, and fostering a culture of safety within radiation environments like cath labs. Novelty: This is a thorough assessment of different radiation protection strategies in the specific setting of a Cath lab. It not only evaluates individual measures but also considers their combined impact and the calculation based on the exit dose from the patient. Keywords: Cardiologist, Radiation Dose, Interventional Radiology, Radiation protection, Cath lab
Comparative Ergonomic Posture Analysis of CNC Milling Machine Workers through Digital Human Modeling and Artificial Neural Networks
Authors:   Assistant Professor, Department of Industrial and Production Engineering, Jashore University of Science and Technology, Jashore, 7408, Bangladesh, Roy Rakesh , Murad Md. Mahafuj Anam , Billah Md. Masum , Talapatra Subrata , Rahman Md Mahfuzur , Biswas Sarojit Kumar
Published: May 2024

Objectives: To analyze the critical postures of the CNC milling machine operators by RULA (Rapid Upper Limb Assessment) scores and develop an ANN (Artificial Neural Network) prediction model. Methods: The methodology includes a postural analysis of 40 male CNC milling machine operators across Bangladesh, employing both manual (using manual RULA assessment worksheet) and digital (using CATIA V5R21 software) RULA methods complemented by an ANN prediction model. Finally, Digital RULA scores through DHM (Digital Human Modeling) and ANN predicted RULA scores would be compared. Findings: Digital RULA analysis reveals that lifting, carrying, and positioning are the most crucial ergonomic postures, and the most prominent high-risk category limbs are wrist and arm. The overall initial RULA score for lifting, carrying, and positioning are 7, 6, and 7, respectively, and reduced to 3, 3 and 4 respectively for ergonomically designed posture. The ANN model, structured with input, hidden, and output layers of 7, 10, and 1 nodes, significantly refines ergonomic risk prediction by aligning predicted scores closely with actual outcomes during the first stage, emphasized for training. It demonstrates a perfect correlation (R=1) in training, testing, validation, and overall performance for using manual RULA scores. The model's accuracy is further evidenced by minimal prediction offsets across all datasets for digital RULA score in the second stage, with correlation coefficients of 0.87003 (training), 0.93676 (validation), 0.89113 (testing), and (0.88395) for overall. This study contributes significant advancements in ergonomic risk assessment, highlighting the adoption of improved postures to reduce musculoskeletal disorders. Novelty: Employing both manual and DHM methods for RULA score calculation combined with ANN model, which can predict postural risk as floating number and fit a wider range of parameters. Keywords: ANN, CNC, Digital Human Modeling (DHM), Ergonomics, RULA
Calcium imaging in astrocytes v1
Authors: Parfitt gustavo.parfitt
Published: May 2024

Calcium imaging in astrocytes
4% PFA + 2.5% Glutaraldehyde Fixative v2
Authors: Institute for Brain Science Allen
Published: May 2024

This protocol is used to prepare 4% Paraformaldehyde (PFA) + 2.5% Glutaraldehyde Fixative. This is utilized to fix the tissue after electrophysiology recordings. Note: Research reported in this publication was supported by the National Institute Of Mental Health of the National Institutes of Health under Award Number U19MH114830. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Production of AAV Virus by Iodixanol Gradient Ultracentrifugation v2
Authors: Institute for Brain Science Allen
Published: May 2024

This protocol is used to produce AAV of any serotype with high purity and high titer. Note: Research reported in this publication was supported by the National Institute Of Mental Health of the National Institutes of Health under Award Number U19MH114830. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Production of Crude AAV Virus Extract v2
Authors: Institute for Brain Science Allen
Published: May 2024

This protocol is used to produce crude preps of AAV of any serotype. Note: Research reported in this publication was supported by the National Institute Of Mental Health of the National Institutes of Health under Award Numbers U19MH114830, RF1MH114126, and RF1MH121274. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Percepção do ambiente e a atividade física em residentes de Cambé
Authors:   Universidade Estadual de Londrina, Rodrigues Souza Yann Ferreira , Badaró Luiz Fernando ,   Universidade Estadual de Maringá, Machado de Oliveira Vinicius ,   Universidade Estadual de Maringá
Published: May 2024

O objetivo deste estudo foi investigar possíveis associações entre a percepção do ambiente e a prática de atividade física no tempo livre em residentes da cidade brasileira de Cambé, no estado de Paraná. Participaram do estudo 873 moradores com idades acima dos 40 anos. Os dados foram coletados por meio de um questionário de resposta única. Para análise dos dados utilizou-se a estatística descritiva e teste de Qui-quadrado (p≤0.05). Verificou-se que 28.3 % dos investigados eram ativos. Além disso, foi possível estabelecer associação entre a percepção positiva do ambiente com a variável idade e a prática regular de atividade física no tempo livre com a variável satisfação com as condições atuais do bairro. Apesar de não identificar associações significativas entre realizar atividade física com morar próximo a locais públicos para estes fins, evidências nos permitem destacar que o ambiente é um fator preponderante para a prática de atividade física.
Heuristic Procedures for the Synthesis of Cutting Hyperplanes in Iterative Algorithms for Solving Mixed Linear Programming with Boolean Variables Problems
Authors:   Novosibirsk State Technical University, Novosibirsk, Russian Federation, Mezentsev Yu. A.
Published: May 2024

The main provisions for one of the promising directions of methods development of mixed integer linear programming are presented. The method is based on an iterative application of a cutting-plane procedure that takes into account, as fully as possible, the properties of the problems being solved. Heuristic procedures are applied for the synthesis of cutting-planes as an intermediate step substantiating the construction of a solution tree. The properties of the generated algorithms are experimentally investigated, the prospects and ways of developing the method and expanding the classes of discrete optimization problems to be solved are determined. The material is illustrated with simple visual examples.
Formation of Thematic Virtual Tours of Cultural Heritage Objects Based on Graph Theory
Authors:   Tambov State Technical University, Morozov V. V. , Nemtinov V. A. ,   Tambov State Technical University, Protasova Yu. V. ,   ambov State University named after G. R. Derzhavin
Published: May 2024

The technology of creating an information virtual space is considered, one of the stages of which is the development of thematic excursions. The article focuses on the development of a virtual guide model, which is based on graph theory, for oriented viewing of objects and events of historical reconstruction. As an example, a historical reconstruction was carried out and a virtual museum was created on memorable places associated with the life and activities of the Chicherin family, whose prominent representatives were G. V. Chicherin and his uncle B. N. Chicherin. Chicherin is one of the founders of the constitutional law of Russia, a philosopher, historian, publicist, teacher. He developed the first model of the atom, an honorary member of the Russian Physico-Chemical Society (on the recommendation of Mendeleev). G. V. Chicherin — the first People's Commissar of Foreign Affairs of the USSR, a diplomat. When creating a virtual historical space, the software environments Twinmotion, Bigscreen and 3DVista Virtual Tour Pro were used. The virtual tour solves a number of tasks: an educational platform for schoolchildren, students; joint remote solution of issues related to the modeling of various studied objects, territories, memorable places; conducting remote online excursions to virtual museums, cultural objects with a guide. Keywords: technology for creating virtual excursions, cultural heritage sites, graph theory, historical reconstruction, virtual space, Twinmotion, 3DVista Virtual Tour, "live"guide, Bigscreen
Hairy roots biochemical characteristics of vegetable pea’s morphotype with modified leaf
Authors: Timina Olga O. , Timin Oleg Yu. , Stepanova Anna Yu.
Published: May 2024

BACKGROUND: In the literature, data on the successful production of high-protein pea root cultures with mutant alleles tl and af tl and their biochemical characteristics are not presented.
AIM: The aim of this study is the biochemical characteristic of the obtained transformed cultures of mutant pea lines with a modified leaf morphotype was. Rol genes clarification of transformed pea mutant lines by wild strains of Agrobacterium rhizogenes and amino acid analysis of the total protein of the obtained roots cultures were objectives of the research.
MATERIALS AND METHODS: Total DNA has been isolated from pea mutant root cultures. The studies were carried out on the equipment of the thermal cycler Tertsik of the company DNA-Technology (Russia). Amplicons were detected by electrophoresis in a 2% agarose gel. The gel was visualized and photographed under ultraviolet light (λ = 312 nm). The quantitative and qualitative amino acid composition of root cultures was determined by ion exchange chromatography on the amino acid analyzer AAA-339 (Microtechna, Czech Republic).
RESULTS: PCR analysis revealed the absence of agrobacterial contamination in the transformed cultures and their stable growth on liquid and agar hormone-free media for 5 years. PCR assay showed the presence of rol C and D genes in culture with the tltl genotype and four rol genes A, B, C, and D in culture with the afaftltl genotype. A differentiated content of a number of amino acids in the biomass of transformed cultures was found depending on the genotype of the culture and the insertion of rol genes. Seven essential amino acids were identified in both cultures.
CONCLUSIONS: Tryptophan turned out to be the limiting essential amino acid for both cultures. In terms of the sum of essential, ketogenic and sulfur-containing amino acids, the culture with the rol genes A, B, C, and D turned out to be the richest and most balanced.
CRISPR/Cas editing of a CPC gene in Arabidopsis thaliana
Authors: Khusnutdinov Emil A. , Panfilova Maria A. , Terekhov Mikhail P. , Mikhaylova Elena V.
Published: May 2024

BACKGROUND: Identification of target genes responsible for visible phenotypic effect may contribute to the development of transgene-free bioengineering strategies and application of crop varieties with edited genome. CAPRICE (CPC) is a single-repeat R3 MYB transcription factor, involved in anthocyanin biosynthesis and trichome formation. It is assumed that CPC controls the expression of Dihydroflavonol-4-reductase (DFR), a key gene of anthocyanin biosynthesis.
AIM: The aim of the study was to determine whether knockout of the CPC gene using CRISPR/Cas9 results in visible anthocyanin accumulation.
MATERIALS AND METHODS: Three guide RNAs were designed to excise a MYB domain from the CPC gene of Arabidopsis thaliana. Anthocyanin content and expression of CPC and DFR genes were studied in edited plants.
RESULTS: The expected 662 bp deletion was detected in 2,7% of glufosinate-resistant plants, however none of the mutations were homozygous. Four edited lines were studied in four generations. An upregulation of the DFR gene was observed in edited lines, however CPC gene expression, anthocyanin content and trichome development were not significantly different from those in control plants. Moreover, in A. thaliana pigmentation did not directly depend on DFR or CPC gene expression.
CONCLUSIONS: Our results suggest that CPC gene is involved in regulation of DFR gene expression and anthocyanin biosynthesis pathway, however in case of mutations plants might utilize other transcription factors to maintain homeostasis. Therefore, CPC gene is not a suitable target for CRISPR/Cas studies in Arabidopsis.
PCR-based genome walking methods (review)
Authors: Okulova Elena S. , Burlakovskiy Mikhail S. , Lutova Ludmila A.
Published: May 2024

The review discusses a range of classical and modern methods used to determine the nucleotide sequence of unknown DNA regions flanking known ones. These methods are applied to decipher the regulatory regions of genes, identify integration sites of T-DNA or viruses, and so on, in cases where the use of whole-genome sequencing is not justified. To amplify a DNA segment, a binding site for a primer must be added to the end of the unknown sequence. This can be achieved either by ligating an adapter or by annealing a degenerate primer under gentle conditions, or by looping the DNA fragment so that the target region is surrounded by known sequences. The second important task is to eliminate the inevitable products of nonspecific binding of adapters or degenerate primers, which is often resolved through multiple rounds of nested PCR. Different methods vary significantly in terms of complexity, prevalence, and the availability of required reagents.
Medical rehabilitation of patients after surgical treatment of prostate adenoma at the third outpatient stage of medical rehabilitation with inclusion of extracorporeal magnetic stimulation
Authors: Nazranov Beslan М. , Tsogoev Alan  S. , Chalaya Elena  N. , Efimenko Natalya V.
Published: May 2024

BACKGROUND: For modern urology the problem of optimisation of approaches to medical rehabilitation of patients after surgical treatment of the prostate gland is relevant due to the high frequency of early and late surgical complications, such as secondary lower urinary tract infections, urodynamic disorders, erectile dysfunction and others.
AIM: To study the effectiveness of medical rehabilitation of patients after surgical treatment of prostate adenoma at the third outpatient stage of medical rehabilitation with the inclusion of extracorporeal magnetic stimulation.
MATERIALS AND METHODS: There have been observed 88 patients after surgical treatment of prostate adenoma. They were divided into 2 groups by simple randomization: in the comparison group (n=43) the patients had physical therapy, psychocorrection, alpha1-adroenblock Tamsulosin, transrectal magnetic therapy at the outpatient stage; in the main group 45 patients were additionally prescribed extracorporeal electromagnetic stimulation. The effectiveness of rehabilitation measures was monitored using ultrasound examination of pelvic organs, uroflowmetry, the assessment of the severity of urinary disorders and quality of life ― the International Prostate Symptom Score (IPSS).
RESULTS: Performing stage-by-stage medical rehabilitation of the patients after surgical treatment of prostate adenoma using extracorporeal electromagnetic stimulation provides a significant leveling of urodynamic disorders (p 0.01), in the comparison group positive dynamics was expressed less (on average by 8–10%) in the absence of intergroup differences. The overall score and Quality of Life index according to IPSS significantly improved (p 0.01) immediately after rehabilitation in the main group, and 6 months later the positive dynamics of these indicators was significantly better compared to those in the comparison group (p 0.05).
CONCLUSION: The implementation of the outpatient rehabilitation program after surgical treatment of prostate adenoma using extracorporeal electromagnetic stimulation provides a significant leveling of urodynamic disorders (p 0.01), restoration of quality of life (p 0.01).
The use of physiotherapeutic methods in the treatment of dry eye syndrome
Authors: Egiazarova Agata G. , Raifeld Alina K. , Korchazhkina Natalya B.
Published: May 2024

The relevance of the treatment of dry eye syndrome is associated with the widespread prevalence of this disease. Along with the development of information technology and an increase in time spent in front of screens, the number of people suffering from this disease is steadily growing.
The basis of treatment for dry eye syndrome is the use of “artificial tears” preparations, which are instilled into the conjunctival cavity to replenish moisture deficiency. But the effect of tear replacement therapy in case of dysfunction of the meibomian glands does not last long. In this regard, the use of physiotherapeutic methods for treating dry eye syndrome to prolong the effect of drug therapy for this pathology is of particular importance.
Each of the methods of physiotherapeutic treatment of dry eye syndrome has its own unique mechanisms of action and indications for use. Physiotherapeutic methods are an effective tool in the treatment of dry eye syndrome, providing the opportunity to improve the quality of life of patients suffering from this common ophthalmic disease.
Effectiveness of complex therapy uncomplicated chronic pelvic pain syndrome
Authors: Sozaewa Larisa  G. , Evstigneeva Inna  S. , Romanovskaya Olga  A.
Published: May 2024

BACKGROUND: Therapeutic measures for chronic pelvic pain are of a pronounced interdisciplinary nature and consist of a complex of various means of influence: pharmacotherapy, physiotherapy and psychotherapy, physical therapy, surgical treatment. The solution to problems is usually achieved by prescribing venotonic drugs of systemic action, which increase venous tone, normalize capillary permeability and resistance, improve the rheological properties of blood, and for the same purpose use antihomotoxic drugs of plant origin. In addition, physiotherapy methods have become widespread in the treatment of patients with pelvic pain syndrome. Currently, pulsed magnetic therapy technologies have been developed in detail, but we hypothesized that the combined use of extracorporeal magnetic stimulation of the pelvic organs and the use of local regeneration cream can ensure mutual enhancement of the effectiveness of therapeutic effects.
AIM: To study the clinical effectiveness and characteristics of vascular reactions in response to combined treatment of pelvic pain syndrome with herbal preparations and extracorporeal magnetic stimulation of the pelvic floor.
MATERIALS AND METНODS: A randomized placebo-controlled study was conducted in 91 patients with chronic pelvic pain (more than 6 months in history). The patients were divided into 3 groups and did not differ significantly in the main studied parameters (age, parity, menstrual function, severity and duration of pain). The 1st group (n=30) patients independently carried out daily monotherapy with a cream stick of plant origin ― rectally, the 2nd group group (n=31) included women who, from the 5th to the 15th day of the menstrual cycle, had a menstrual cycle for 10 days procedures for extracorporeal magnetic stimulation of the neuromuscular apparatus of the pelvic floor; after completing the course of physiotherapy, a herbal preparation of rectal origin was prescribed daily; group 3 (n=30) included female patients who underwent physiotherapy procedures.
RESULTS: It was found that patients suffering from chronic pelvic pain need to undergo complex treatment, including physiotherapy techniques and rectal preparations of herbal origin. In groups receiving combination therapy for chronic pelvic pain, a long-term clinical effect was obtained; these data correlate with ultrasound parameters.
CONCLUSION: It has been established that women suffering from chronic pelvic pain should undergo a comprehensive treatment including physiotherapy techniques, in particular extracorporeal magnetic stimulation of the pelvic organs, and rectal preparations of herbal origin.
Superselective ablative chemo-ethanol embolization for recurrent single hepatocellular carcinoma: a 6-month outcome analysis
Authors: Lee Jae Hwan , Kim Kun Yung , Lee Chong-ho , Kim Minuk , Yoon Chang Jin
Published: May 2024

Backgrounds/Aims: To evaluate the safety and effectiveness of superselective ablative chemo-ethanol embolization (SACE) for the treatment of patients with recurrent single hepatocellular carcinoma (rHCC).Methods: This retrospective study included 22 patients (19 men; median age, 63 years [range, 38-86]) with Child-Pugh class of A/ B/C (16/3/3) that underwent SACE between January and June 2023 for recurrent single HCCs measuring ≤5 cm in diameter using a mixture of 99% ethanol and ethiodized oil/doxorubicin emulsion. The primary endpoint was the 6-month tumor response, and the secondary endpoints were the 1-month tumor response and treatment-related safety. This study was approved by our institutional review board, and the requirement for informed consent was waived.Results: SACE was successfully performed in 22 patients (95.2%). The complete response rates at 1-month and 6-month after treatment were 100.0% and 83.3%, respectively. At 6-month, local tumor progression occurred in one patient and intrahepatic distant metastasis was found in six patients (30.0%). No 6-month mortalities were reported. No adverse events greater than grade 2 or laboratory deteriorations were observed. Biliary complications or liver abscesses were not observed.Conclusions: SACE for a single rHCC was highly effective in achieving a favorable 6-month tumor response and showed acceptable adverse events. However, further prospective studies are required to verify these findings.
Assessment of the Level of Matrix Metalloproteinases, VEGF and MicroRNA-34a in Patients With Non-obstructive and Obstructive Lesions of the Coronary Arteries
Authors: Iusupova A. O. , Slepova O. A. , Pakhtusov N. N. , Popova L. V. , Ageev A. A. , Lishuta A. S. , Privalova E. V. , Khabarova N. V. , Dadashovа G. М. , Belenkov Yu. N.
Published: May 2024

Aim. To assess the levels of matrix metalloproteinases (MMP), vascular endothelial growth factor (VEGF), and miRNA-34a expression in patients with ischemic heart disease (IHD) and obstructive and nonobstructive coronary artery (CA) disease.

Material and methods. This cross-sectional observational study included 64 patients with IHD (diagnosis verified by coronary angiography or multislice computed tomography coronary angiography), of which 33 (51.6%) were men aged 64.9±8.1 years. 20 patients had nonobstructive CA disease (stenosis <50%), and 44 had hemodynamically significant stenoses. The control group consisted of 30 healthy volunteers. MMP-1, -9, -13, and -14, miRNA-34a, and VEGF were measured in all patients.

Results. The concentration of MMP-1 was significantly higher in patients with ischemia and nonobstructive CA disease (INOCAD) (p=0.016), and the concentration of MMP-9 was the highest in the group with obstructive CA disease (p<0.001). The concentrations of MMP-13 and MMP-14 did not differ significantly between the groups. The highest VEGF concentrations were observed in the INOCAD group (p<0.001). The expression of miRNA-34a significantly differed between the IHD groups with different types of CA disease and controls (p <0.001). Patients with hemodynamically significant stenosis showed moderate relationships between the concentrations of MMP-14 and VEGF (ρ=0.418; p=0.024), as well as between VEGF and miRNA-34a (ρ=0.425; p=0.022). Patients with INOCAD had a significant negative correlation between the concentrations of MMP-13 and VEGF (ρ= –0.659; p=0.003). Correlation analysis showed in all IHD patients a moderate relationship of the concentrations of MMP-1 and MMP-14 with VEGF (ρ=0.449; p=0.002 and p=0.341; p=0.019, respectively). According to ROC analysis, a MMP-9 concentration above 4.83 ng/ml can be a predictor for the presence of hemodynamically significant CA obstruction in IHD patients; a VEGF concentration higher than 27.23 pg/ml suggests the absence of hemodynamically significant CA stenosis.

Conclusion. IHD patients with INOCAD had the greatest increase in MMP-1, whereas patients with obstructive CA disease had the highest level of MMP-9. According to our data, concentrations of MMP-9 and VEGF can be used to predict the degree of CA obstruction. The expression of miRNA-34a was significantly higher in IHD patients with INOCAD and CA obstruction than in the control group, which suggested a miRNA-34a contribution to the development and progression of coronary atherosclerosis. In the future, it may be possible to use this miRNA as a diagnostic marker for IHD.
Anthracycline-induced Heart Failure: Treatment and Recovery Prospects
Authors: Vitsenya M. V. , Potekhina A. V. , Filatova A. Yu. , Stukalova O. V. , Ageev F. T.
Published: May 2024

The article presents a clinical case of heart failure associated with the anthracycline-containing antitumor therapy in a breast cancer patient with an initially low risk of developing cardiovascular complications.
Changing Concepts About Optimal Target Blood Pressure and the Therapeutic Advantages of Azilsartan for Achieving it
Authors: Gilarevsky S. R.
Published: May 2024

The article discusses current issues of the treatment of arterial hypertension. According to presented data, so-called therapeutic nihilism is becoming one of the main barriers to achieving target blood pressure (BP). This nihilism is that despite evidence of the effectiveness of achieving lower BP values, practitioners do not intensify antihypertensive therapy sufficiently to achieve such values. The article specially addresses new criteria for the effectiveness of antihypertensive therapy, which reflect the therapy sustainability. The most commonly used indicator is the duration of the period, during which systolic BP remains in the therapeutic range. The prognostic significance of such indicators is discussed. In these conditions, it is very important to use the most effective antihypertensive drugs for initial antihypertensive therapy, including as a part of combination therapy. This tactic provides more frequent achievement of BP goals without the need for dose adjustment. In this regard, a systematic review was performed, which included sufficiently large randomized studies of the antihypertensive effectiveness of azilsartan medoxomil. This systematic review will provide comprehensive information on a possible role of using the angiotensin II receptor blocker azilsartan as a basic drug for the treatment of a wide range of patients with high BP. Most of the studies included in the systematic review assessed the effectiveness of combination therapy including azilsartan.
Contribution of MASK-air® as an mHealth Tool for Digitally Enabled Person-Centered Care in Rhinitis and Asthma
Authors: Sousa-Pinto B , Fonseca JA , Bousquet J
Published: May 2024

In chronic diseases, mHealth apps help to improve clinical management and provide valuable real-world scientific evidence. In allergic rhinitis, a market research study identified only 4 mHealth apps that were multilingual, resulted in scientific publications, and displayed a comprehensive list of medications. Of these 4 apps, MASK-air® generated the highest number of scientific publications. MASK-air was launched in 2015 and is currently available in 30 countries, with data collected from more than 30 000 users. It comprises a daily monitoring questionnaire, enabling patients to register their daily allergy symptoms by means of visual analog scales and their medication use. The achievements of MASK-air include the development of 2 digital biomarkers for daily monitoring of rhinitis and asthma (combined symptom-medication score and electronic daily asthma control score). MASK-air data have also made it possible to assess patients’ behavior, suggesting that patients do not follow guideline recommendations, but rather treat themselves (and often use comedication) when they feel worse. Using MASK-air data, we quantified the impact of allergic diseases on quality of life and school and work productivity. Realworld MASK-air data are being used as a source of evidence for the Allergic Rhinitis and its Impact on Asthma 2024 guidelines in an innovative process of incorporation of mobile health data into guidelines. This review discusses the clinical and scientific contributions of MASK-air to person-centred care of rhinitis and asthma, providing an illustrative example on the use of mHealth data in chronic diseases.
Development of Hybrid Project-Based Learning Model for Multimedia Technology and Animation
Authors:   Technology and Vocational Education Study Program, Faculty of Engineering, Universitas Negeri Padang, Padang, Indonesia, Ramadhan Muhammad Sabir
Published: May 2024

Technological advancements, global initiatives, and digitization have led to a sustained demand for highly qualified engineers. However, the current state of engineering education has drifted apart from real-world requirements. Thus, it is crucial to identify the specific skills lacking in engineering graduates. Additionally, this research results can be useful for curriculum development, fostering collaboration between academic institutions and industry partners, and improving students’ skills. This study aims to introduce a pioneering educational model that combines hybrid learning and Project- Based Learning (PBL) to address the needs and preferences of college students in the fields of multimedia technology and animation. The paper presents the development and implementation of the method, including an assessment of learner characteristics, expert assessments, peer evaluations, and limited tests. The experts involved as validators comprised three individuals from the fields of education, animation, and industry practitioners. The product testing was conducted in two classes: a control class with 20 students and a limited experimental class with 15 students. Based on the paired sample t-test, p-values of 0.001 for the multimedia technology course and 0.002 for the animation course were obtained at a significance level of 0.05. This suggests that there is a significant difference in the classes that implement the Hybrid Project- Based Learning (H-PBL) model. Additionally, instructional products were developed, including a model book, a learning materials book, a user guide for lecturers, a user guide for students, and teaching modules. Furthermore, this research also yielded an e-learning platform and online modules.
Por qué y cómo desarrollar centros de día: contribuyendo al bienestar de las personas mayores y cuidadoras
Authors: Benedetti Fiorella , Sancho Mayte , Hernández Marian
Published: May 2024

El acelerado proceso de envejecimiento poblacional en América Latina y el Caribe conlleva un aumento en el número de personas mayores que necesitan cuidados. Uno de los desafíos de la región radica en desarrollar servicios de cuidado a escala que respeten la preferencia de la mayoría de las personas de envejecer en sus hogares y que alivien la carga de cuidado de las familias. En este estudio analizamos los centros de día en América Latina e internacionalmente, en particular, en Uruguay, Argentina, México, Estados Unidos y Francia. Además, recopilamos los múltiples beneficios de los centros de día para sus usuarios, las personas cuidadoras familiares y el sistema sociosanitario, así como sus precios en la región. El precio de los centros de día es de 234 dólares por mes, un valor más bajo que otros servicios de cuidado. Un valor añadido de este estudio es que, basándonos en los aprendizajes de las buenas prácticas, hemos desarrollado una guía operativa sobre cómo diseñar e implementar centros de día de calidad siguiendo el enfoque de Atención Centrado en la Persona. Asimismo, aportamos recomendaciones detalladas sobre los recursos físicos (espacio, equipamiento y transporte), los recursos humanos y sobre cómo organizar el día a día del centro, incluyendo la elaboración de itinerarios personalizados para cada usuario.
Virágnak virága
Authors: Csehy Zoltán
Published: May 2024

A tanulmány az Ómagyar Mária-siralom költői utóéletét, hatását tárja fel a szövegalkotási stratégiák mentén. Ezek a stratégiák a nyelven belüli fordítástól az átköltéseken, empatikus hódolatokon, parafrázisokon, továbbírásokon és a montázsszövegként való újrahasznosításon át egészen a parodisztikus vagy regiszterváltó áthangolásokig terjednek. Az Ómagyar Mária-siralom költői kontextualizálása is meglehetősen sokféle: a filológiai rekonstrukció illúziója éppoly fontos lehet, mint például a devóciós dráma vagy a planctus műfaja felőli megközelítés. Számos intermediális, határsértő kísérlet is született, a vers belépett a képzőművészet vagy a performace-művészet terébe is, de a neoavantgárd irodalom is kitermelte a maga variánsait. A költemény modern áthangolásai gyakorta a veszteségköltészet, a halállíra, illetve a traumapoézis kortárs eszköztárának köszönhetően válnak eleven szövegekké. A tanulmány többek között Weöres Sándor, Rákos Sándor, Áprily Lajos, Szkárosi Endre és Galántai György, Schein Gábor és Erdős Virág verseit elemzi.
Impact of medical innovations on quality of care in low income settings
Authors: Sigala, MD Gana Romanus , Michel Tchadie Alain
Published: May 2024

Access to high-quality healthcare remains a challenge in low-income settings, primarily due to resource constraints and limited access to medical innovations. This systematic review examines the impact of medical innovations on the quality of care in low-income settings. Through a comprehensive analysis of relevant literature, this paper highlights the various medical innovations that have been implemented in low-income settings and evaluates their effectiveness in improving healthcare outcomes and patient satisfaction.
The review identifies three broad categories of medical innovations: technological innovations, innovative healthcare delivery models, and novel treatment modalities. Technological innovations encompass a wide range of advancements, including telemedicine, mobile health (mHealth) applications, and point-of-care diagnostics. These innovations have shown promise in improving access to healthcare services, enhancing diagnostic accuracy, and facilitating remote monitoring and follow-up care in low-resource settings.
Innovative healthcare delivery models, such as community health worker programs, task shifting, and mobile clinics, have also been implemented to overcome barriers to healthcare access in low-income settings. These models prioritize community engagement, decentralization of services, and task delegation to non-physician healthcare providers to expand coverage and reach underserved populations.
Furthermore, novel treatment modalities, including affordable and portable medical devices, point-of-care testing kits, and low-cost medications, have been developed to address the specific healthcare needs of low-income populations. These innovations aim to improve treatment efficacy, reduce treatment costs, and minimize the burden of disease in resource-limited settings.
The review synthesizes evidence from a diverse range of studies to assess the impact of these medical innovations on healthcare outcomes and patient satisfaction. Key findings suggest that while medical innovations hold promise in enhancing quality of care, several challenges including limited resources, infrastructure constraints, and training requirements need to be addressed to maximize their impact.
The paper concludes by emphasizing the importance of tailored approaches and sustainable strategies for implementing medical innovations in low-income settings. By fostering partnerships, leveraging existing infrastructure, and investing in capacity building initiatives, stakeholders can effectively integrate medical innovations into healthcare delivery systems and improve access to high-quality care for underserved populations.
This systematic review contributes to the growing body of literature on healthcare innovation and provides valuable insights for policymakers, healthcare providers, and researchers seeking to address the healthcare needs of low-income populations and achieve health equity on a global scale.
Contractual Regulation of the Corporate Subordination of Legal Entities
Authors:   Senior Lawyer of the Legal Department of Research and Innovation Center Agrovetzaschita S-P, LLC, PhD (Law), Vasin Valery V. , Maltsev Anton K. ,   Lawyer
Published: May 2024

Agreements establishing relations of subordination between legal entities are the least studied in the science of civil law. Despite the fact that Russian legislation contains the legal basis for the use of such agreements in practice, at the same time, it lacks a detailed elaboration of its conditions. In this regard, it seems necessary and relevant to conduct a theoretical study of the legal nature of the agreement regulating the relationship between the main and subsidiary companies.