bluuebunny/crossref_metadata_2025 huggingface dataset:
Prognostic factors in the treatment of androgenetic alopecia with minoxidil
Authors: Tsimbalenko T. V. , Gadzhigoroeva A. G. , Potekaev N. N. , Tereshchenko G. P. , Mikhalchik E. V.
Published: March 2023

Introduction. Androgenetic alopecia (AGA) is the most common type of alopecia, characterized by diffuse progressive thinning of the hair in the fronto-parietal area in patients with a genetic predisposition. Topical minoxidil remains the primary pharmacological treatment for AGA both in men and women. The efficacy in hair regrowth is reported to be between 40 and 50%.Aim. To evaluate prognostic factors of minoxidil response in AGA patients.Matherials and methods. The prospective open study was carried out. Thirty participants with AGA were enrolled and completed the study (twenty one women I–II Ludwig stage and nine men I–III Hamilton – Norwood stage). Primary outcomes consisted of measuring of hair density, telogen hair rate, the percentage of vellus hairs and hair diameter at baseline and repeated at 4 months. The SULT1A1 enzyme activity and the concentration of ATP in plucked hairs were measured at baseline. Patients were treated with 5% topical minoxidil applying daily for 4 months. In order to investigate prognostic factors in groups of responders and non-responders to minoxidil treatment these measured morphometric and biochemical characteristics were assessed.Results. After 4 months of treatment 77% of patients demonstrated hair regrowth and improvement of hair density, hair diameter and decrease of vellus hairs level. The SULT1A1 enzyme activity (p = 0.0008), the concentration of ATP (p = 0.004) in plucked hairs and baseline total hair density (p = 0.01) was significantly lower in group of non-responders compared to group of responders. The study demonstrated strong positive correlation between SULT1A1 enzyme activity and increase of total hair density (r = 0.7, р = 0.00002); moderate positive correlation was founded between concentration of ATP and increase of total hair density (r = 0.6, р = 0.0004).Conclusion. The negative prognostic factors for minoxidil treatment of AGA include SULT1A1 enzyme activity, concentration of ATP in plucked hairs and low total hair density at baseline.
Design of DEA water efficiency evaluation model for cotton field irrigation in Xinjiang
Authors: Zheng Zipiao , Wei Xin , Wang Liang , Guo Rensong , Xu Haijiang
Published: March 2023

Current irrigation water use efficiency assessment methods cannot accurately predict irrigation water use, leading to greater errors in water use efficiency assessment. Therefore, a new method based on data envelopment analysis (DEA) model is proposed to evaluate the irrigation water use efficiency of cotton fields in Xinjiang. The super efficiency DEA model is established by introducing the super efficiency DEA method and adjusting the predicted amount and actual amount of irrigation water use. Genetic algorithm is used to improve the super-efficiency DEA model. The indexes obtained include the indexes reflecting water resources conditions, water use situation and economic aspects, and the statistical sequence model of cotton field irrigation water information is established. Given the demand and actual usage of irrigation water for cotton fields, the numerical relationship between the demand and usage was defined by integrating the two indices as the index data set. The experimental results show that the proposed method can accurately predict the water consumption of cotton field irrigation, and the efficiency of irrigation water consumption can reach 90%.
EpiSemble: A Novel Ensemble-based Machine-learning Framework for
Prediction of DNA N6-methyladenine Sites Using Hybrid Features
Selection Approach for Crops
Authors: Sinha Dipro , Dasmandal Tanwy , Yeasin Md , Mishra Dwijesh C. , Rai Anil , Archak Sunil
Published: March 2023

Aim:

The study aimed to develop a robust and more precise 6mA methylation prediction tool
that assists researchers in studying the epigenetic behaviour of crop plants.

Background:

N6-methyladenine (6mA) is one of the predominant epigenetic modifications involved in
a variety of biological processes in all three kingdoms of life. While in vitro approaches are more precise
in detecting epigenetic alterations, they are resource-intensive and time-consuming. Artificial intelligence-
based in silico methods have helped overcome these bottlenecks

Methods:

A novel machine learning framework was developed through the incorporation of four techniques:
ensemble machine learning, hybrid approach for feature selection, the addition of features, such
as Average Mutual Information Profile (AMIP), and bootstrap samples. In this study, four different feature
sets, namely di-nucleotide frequency, GC content, AMIP, and nucleotide chemical properties were
chosen for the vectorization of DNA sequences. Nine machine learning models, including support vector
machine, random forest, k-nearest neighbor, artificial neural network, multiple logistic regression,
decision tree, naïve Bayes, AdaBoost, and gradient boosting were employed using relevant features extracted
through the feature selection module. The top three best-performing models were selected and a
robust ensemble model was developed to predict sequences with 6mA sites.

Results:

EpiSemble, a novel ensemble model was developed for the prediction of 6mA methylation
sites. Using the new model, an improvement in accuracy of 7.0%, 3.74%, and 6.65% was achieved over
existing models for RiceChen, RiceLv, and Arabidopsis datasets, respectively. An R package, EpiSemble,
based on the new model was developed and made available at https://cran.rproject.
org/web/packages/EpiSemble/index.html.

Conclusion:

The EpiSemble model added AMIP as a novel feature, integrated feature selection modules,
bootstrapping of samples, and ensemble technique to achieve an improved output for accurate prediction
of 6mA sites in plants. To our knowledge, this is the first R package developed for predicting
epigenetic sites of genomes in crop plants, which is expected to help plant researchers in their future explorations.
Fiber Wireless (FiWi) Access Network Planning & Deployment using
Reptile Search Algorithm
Authors: Chouhan Nitin , Bhatt Uma Rathore , Bhat Vijay
Published: March 2023

Aim:

The aim of this study is the deployment of components in an efficient manner to
make a cost-effective FiWi network.

Background:

Fiber Wireless access network is the boost to broadband access technology for providing
network services to Internet users at a lower cost. Deployment of components in FiWi access network
is very crucial since it affects the deployment cost and network performance.

Objective:

We investigate the planning process for efficient placement of components in FiWi access
networks. For optimizing the position of components (wireless routers and ONUs) in the network, a
novel nature inspired Reptile Search Algorithm (RSA) is proposed in the paper.

Methods:

Extensive simulation is carried out to implement proposed work. A simulation model and
code is developed in MATLAB to get the optimized position of components for existing and proposed
algorithms.

Result:

We compare the performance of proposed algorithm with existing algorithm. The obtained
results show that the proposed algorithm has superior performance than the existing algorithm.

Conclusion:

The present work optimizes the position of components using RSA algorithm. RSA returns
the lower number of required wireless routers/ONUs, lesser TCD, increased AONUC, fast convergence
rate, lesser execution run time than WSSA algorithm. The outcome of the paper highlights
the importance of the proposed work in network planning and component deployment in FiWi access
network.
Art et modernisation dans la presse carioca des années 1960: la mode dans les pages du Correio da Manhã et du Jornal do Brasil
Authors: Corrêa Clecius Campos , Bueno Maria Lucia
Published: March 2023

In the early 1960s, one can register, internationally, a growth in the population of modern artists and an expansion of the limits of the art world, whose works were marked by the visual perception of everyday life and art objects aligned to universes little explored until then. In Brazil, a country in the process of modernization and expansion of the consumer society, some precariousness in the industry and in the market were responsible for an unprecedented role of artists in the implementation and modernization of new sectors, such as fashion and the press. Thisarticle examines the contribution of artists and intellectuals in the construction of these sectors in Rio de Janeiro. The carioca press played a prominent role in the dissemination and legitimation of the products and effects of these actions.
A crítica de rock repaginada e despaginada. Da autoridade no jornalismo cultural à plataformização e performance de gosto
Authors: Alberto Thiago Pereira , Pilz Jonas
Published: March 2023

On this paper we discuss the current potentialities of rock n' roll critics, highlighting its production, reception and circulation scenarios by the platformization perspective and understanding the current criticism as a taste performance. We refuse the idea that the criticism itself became obsolete, as it has been claimed by some, and argue that, in fact, there is a repositioning process that led into the current rock critics escaping the big newspapers and magazines and having no requirement of a journalism academic degree. We present a short chronology of arts journalism, focused on culture, and rock criticism, as part of the journalism based on opinion, where the rock journalists used to claim their authorities because of their repertory and authenticity. Our main purpose here is to demonstrate that not just these values are no longer determinant for one to publish his own critics, but criticism is now less of a judgment of taste than it is a horizontally and immediatism mediation. It is not a sentence defining made by one if something is good or bad -or must be bought or not -but a sharing of taste to and by many.
A música eletrónica ambiental: da profundidade sonora aos imaginários da mente
Authors: Dinis Frederico
Published: March 2023

This article departs from the definition for ambient electronic music, as an inductive element for the creation of a space to think, and presents a set of authors and sound works orientated towards a concern with space. These authors are contextualised according to the foundations of contemporary electronic music, from the mid-20th century and which are based on works that revolutionised the way in which electronic music came to be seen, up to the new expansion of electronic ambient music, with the appearance of new sonorities and new paths for this musical genre as from the 2000s, consolidating and stabilising it as a musical genre. But electronic ambient music as a genre should be seen as an overlapping of information, and not only as an interaction with an environment. Thus, we argue that the social connection of electronic ambient music to its own environment and context has changed throughout its evolution as a genre, just as this context has changed, reinforcing that the place today is a personal space, just like the listening experience associated with electronic ambient music. The present-day experience of electronic ambient music in the conception, amplification or discontinuity of places, expresses in itself the desire to exercise an internal agency or a mediation with its own surroundings, operating as a reflection of the 'I', recurring to sonorities that move the mind. An 'I' that includes the social world in which one is immersed and a representation of figurative places.
Vida e morte nas pinturas de natureza-morta do século XVII holandês
Authors: Bortulucce Vanessa Beatriz
Published: March 2023

The purpose of this article is to make some reflections about a specific type of art that, in a large part of its history, was especially concerned with the issues of death and the transience of existence: still-life paintings, especially those made by the Dutch in the 17th century. For that, it is necessary to retrace a path about the history of this genre, to then analyze the works of the period, and, in them, visualize the symbolic universes that alert us to the brevity of existence
Renewable Energy on Islands: Lessons for Indonesia to Apply
Authors:   Public Administration Study Program, STISIPOL Raja Haji, Rianto Faizal , Utari Diah Siti , Jenawi Billy , Sujarwani Riau
Published: March 2023

The purpose of this article is to review and analyse the development of applied renewable energy in Indonesia. Indonesia has achieved 91.16% electrification rate in 2016, and in 2024 planned to achieve 100% electrification for its population. Lack of electricity access, however, is common throughout Indonesia. Provinces in eastern Indonesia such as Nusa Tenggara Timur and Papua Barat has the lowest electrification ratio, while provinces such as Nusa Tenggara Barat, Sulawesi Tenggara, Kalimantan Tengah, Kalimantan Utara, and Kepulauan Riau has less than 80% electrification rate. Out of the 34 provinces, only Bangka Belitung, Jawa Barat, and Jakarta have the electrification ratio above 99% in 2016. Providing electricity access to the population is proven to be difficult due to Indonesia’s archipelagic geography which acted as a barrier and poses a challenge in electrification efforts. Studies, however, have shown the potential use and application of renewable energy to provide electricity to islands and archipelagos. It is therefore important for Indonesia to take note that renewable energy initiatives, particularly on islands and archipelagos, are not only yielding positive results socially, economically, and environmentally, but it is also viable and feasible to implement.
The Usefulness of a Smartphone App–Based Smoking Cessation Program for Conventional Cigarette Users, Heated Tobacco Product Users, and Dual Users: Retrospective Study
Authors: Noda Yuko , So Ryuhei , Sonoda Misaki , Tabuchi Takahiro , Nomura Akihiro
Published: March 2023

Background

Heated tobacco products (HTPs) are widespread in Japan, and smoking cessation of such products has become an important issue owing to the spread of harmful effects from HTPs. The efficacy of online digital therapy has been reported in smoking cessation treatment; however, we have limited evidence of online smoking cessation programs for HTP users.

Objective

In this study, we evaluate the usefulness of the Ascure program for HTP users (defined as exclusive HTP use or dual use of HTP and cigarettes) compared with exclusive cigarette users.

Methods

This was a retrospective study. We recruited adult smokers participating in the Ascure online smoking cessation program in Japan from June 2019 to February 2021. The Ascure smartphone app provided four elements: (1) educational video tutorials to enhance the understanding of nicotine dependence, (2) a personalized to-do list for behavior change, (3) a digital diary for record keeping, and (4) interactive chat sessions for relief from cravings or withdrawal symptoms. The primary outcome was the continuous abstinence rate (CAR) at weeks 21 to 24, biochemically validated using salivary cotinine testing. We considered those who dropped out of the program as smoking cessation failures. We analyzed the primary outcome using inverse probability weighting against tobacco product type estimated by multinomial propensity scores. We also assessed CAR at weeks 9 to 12 and program adherence.

Results

We analyzed data from 2952 participants, including 52% (1524/3478) in the cigarette group, 35% (1038/3478) in the HTP group, and 13% (390/3478) in the dual-use group, who had a mean age of 43.4 (SD 10.8) years and included 17% (513/2952) women. CAR at weeks 21 to 24 showed that exclusive HTP users were more likely to stop tobacco use than exclusive cigarette smokers (CAR 52.6% for cigarette users vs CAR 64.8% for HTP users; odds ratio [OR] 1.17, 95% CI 1.12-1.22; P<.001). There was no significant difference between the exclusive cigarette users and the dual users (CAR 52.6% for cigarette users vs CAR 48.7% for dual users; OR 0.99, 95% CI 0.93-1.05; P=.77). CAR at weeks 9 to 12 was 56.7% (95% CI 54.2%-59.2%) for the exclusive cigarette users, 68.3% (95% CI 65.5%-71.1%) for the exclusive HTP users, and 58.2% (95% CI 53.3%-63.1%) for the dual users. The program adherence rate at week 24 was 70.7% overall (68.4% for cigarette users, 75% for HTP users, and 67.9% for dual users).

Conclusions

Exclusive HTP users had higher CARs and adherence compared with exclusive cigarette users, indicating a higher affinity for the Ascure online smoking cessation program. This program might be a useful smoking cessation option for HTP users, as well as for cigarette smokers.
ASSESSMENT OF TEACHING METHOD PREFERENCES AMONG DENTAL AND MEDICAL STUDENTS
Authors: Shaikh Shoyeb , L Vyas Megha , Pathak Shivang
Published: March 2023

Objectives: The objectives of this study were to evaluate the teaching approach choices among dental and medical college students.
Methodology: This survey examines how medical and dental students use their visual, auditory, reading-writing, and kinesthetic senses. It is a descriptive cross-sectional survey.
Results: According to VARK, it was found in the current survey that most students chose a single mode of learning (uni modal) – roughly 77% of clinical students and 83% of dentistry students. Tri modal was found to be the least preferred among medical students, with bi modal coming in second with 22% of scientific students and 15% of dentistry students. About 1% of dentistry students were observed using a quad modal method. A-auditory approach was found to be the most popular among medical students, with a median of 2.80, followed by utilizing OK-kinesthetic with a mean of 1.89, and R/W-studying or writing with a mean of 1.65 dentistry college students. A–auditory become the maximum desired approach with a median of two forty, accompanied by okay – kinesthetic with a mean of 2.01 and 1.67for R/W – analyzing or writing
Conclusion: According to the study’s findings, kinesthetic mode used most frequently to observe the auditory form of instruction. Both dentistry and medical students were shown to prefer the written style over the visual one. Most of the students selected more than one learning option or had multimodal options.
EARLY SURGICAL OUTCOMES OF OPERABLE BREAST CANCER PATIENTS BASED ON MOLECULAR SUBTYPING – A SINGLE-CENTRE STUDY
Authors: VERMA VISHAL , HIREMATH RAVISHEKAR N , BASRA SHARANJIT SINGH , KULKARNI PRANAV CHANDRAKANT , GHODKE SANDHYA
Published: March 2023

Objectives: The aim of the study was to assess patients belonging to four main molecular subtypes (Luminal A, Luminal B, HER2 neu positive and Triple negative) and their treatment plans with a view to compare their early surgical complications and the final outcomes specific to the surgical procedure adopted and molecular subtype.
Methods: A Cross-sectional observational study at a Tertiary care center in central UP in a two-year period with Inclusion Criteria and Exclusion Criteria. Data Collection was carried out from the patients, diagnostic confirmation to rule out any exclusion criteria was performed. Clinical staging was done using the standard TNM criteria. All the specimens were subjected to immune-histochemical evaluation for surrogate molecular subtyping to see later the early surgical outcomes.
Results: Mean age ranged from 47.57±9.57 (Group III) to 50.67±8.08 (Group II) years and BMI ranged from 23.71 (Group IV) to 26.38 kg/m2 (Group II). Neoadjuvant chemotherapy use was reported in 15.6% of Luminal A group, 33.3% of Luminal B group, 40% of Her2 negative and 52.2% of Triple negative group cases. Statistically, there was a significant difference among groups with respect to use of neoadjuvant chemotherapy. Breast conservation therapy was the preferred surgical intervention in majority of cases with Luminal A (60%) and Luminal B subtype (66.7%) whereas MRM was preferred in 54.3% of Her2 negative and 65.2% of Triple negative cases. MRM was performed in 36% of Luminal A cases. Primary surgical intervention failure (BCS) was seen in 1 (4%) case with Luminal A subtype. In this patient, mastectomy was performed as the corrective measure. Surgical site infection was noted in 1 (4%) case in Luminal A group only. Seroma formation was noted in 4 (16%) of Luminal A, 8 (22.9%) of Her2 negative and 2 (8.7%) of Triple negative patients. No case of flap necrosis was noted. Follow-up duration ranged from 15 days to 36 months. Median duration of follow-up was 6 months. No mortality was noticed in any group.
Conclusion: Different surgical management strategies suggested that breast conservative surgery was more feasible in Luminal A cases whereas MRM was the preferred mode of surgery in other molecular subtypes. Within the limitations of short duration of follow-up, there was no significant difference among different molecular subtypes with respect to late complications and survival. Further studies with longer duration of follow-up and larger sample size are recommended.
A COMPARATIVE STUDY OF MEDICAL DEVICES AND THEIR REGULATIONS IN US, EU, INDIA, AND CHINA
Authors: S NAGA SWAROOPA , K VENKATESWARA RAJU , NL PRASANTHI
Published: March 2023

The usage of medical device is on the rise due to the rise in incidence rate of chronic diseases, irregular health check-ups, and sedentary lifestyles and also rising cases of obesity, diabetes, neuro-based disorders, heart diseases, and chronic diseases relating to lifestyle disorders. Availability of hassle free home monitoring medical devices that can be used even by patients with no knowledge about the technical aspects made their way into patient homes. Even in the presence of restraining factors such as high cost and reimbursement issues, the opportunities for medical device professionals lie in the technological advancements and usage of internet of medical things in modern healthcare and the latest trend toward developing smart medical devices with fast development in (AI) and (ML). The usage of medical devices is on the rise due to medical device development is undergoing a huge technological advancement due to emergence 3D printing which allows development of devices designed specifically as per patient requirements. Medical devices like freestyle liber system by Abbott laboratories eliminate need for routine finger pricking as it has sensor that measures and records glucose levels through clothing of the consumer. Quickie Q300 M mini Wheelchair fits even in tight doorways, navigates restaurants, that are crowded and also in difficult living spaces. Harmonization of medical devices registration across the markets is essential to paue way for their easy approval and also in dealing with the withdrawn issues related to quality, safety, and performance. This review involves a comparative study of medical device regulations in four regions (US, EU, India and China).
ROLE OF ANTIBIOTIC BEADS IN MANAGEMENT OF COMPOUND FRACTURE LONG BONES
Authors: Kumar Mohit , Pachori Sachin , Choudhary Laxman , Mehra Chetan
Published: March 2023

Objective: The aim of the study was to assess role of antibiotic beads in the management of compound fracture long bone.
Methods: Twenty-four patients with compound long bone fracture (Grade II, IIIA, and IIIB) operated with initial debridement, fracture stabilization, and antibiotic coated beads. All patients were followed-up till at least 6 months. All patients were evaluated clinically and radiologically for functional outcome.
Results: Seventeen patients (71%) were male while 7 patients (29%) were female. Mean age at the time of surgery was 34.5 years (Range: 20– 70 years). Sixteen patients had fracture on the right side while the eight patients had on the left side. Sixteen patients had Type II compound injury (67%), five patients had Type IIIA (21%), and three patients had Type IIIB compound injury (12%). The average time of union was 16 weeks in 6 patients (26.06%), 12–14 weeks in 8 patients (34.78%) and 18–22 weeks in 9 patients (39.14%). Out of 24 cases, only one case had superficial infection, one case has deep infection, three patients had raw skin area, one patient developed post-operative knee stiffness, and another had 1 cm limb shortening. Functional outcome is seen as six patients with excellent outcome, eight patients with fair outcome, nine patients with good outcome, and one patient had poor outcome.
Conclusion: The study concludes the use of antibiotic coated beads in compound fracture significantly reduces the infection in compound fracture of Grade II, Grade IIIA, and IIIB. Antibiotic impregnated beads delivers higher concentration of local antibiotics to wound site which helps in hastening recovery of wound. This reduces hospital stay and morbidity.
DNA DAMAGE IN LENS EPITHELIAL CELLS OF SENILE CATARACT PATIENTS OF DIFFERENT PRAKRITI ACCORDING TO AYURVEDA LITERATURE
Authors: Jadhao Avinash Namdeo , Santosh Sorte Gawali Kranti , Chandrakant Lokhande Manoj , Shravani S Parate
Published: March 2023

Objectives: The Ayurvedic concept of the constitution is useful in predicting an individual’s susceptibility to age-related diseases like Cataracts (Kaphaja Linganasha). The objectives of the study were to assess DNA damage directly in human lens epithelial cells (HLEC) of senile cataracts of Vata Predominant, Pitta Predominant, and Kapha Predominant Prakriti individuals.
Methods: After obtaining Institutional Ethics Committee permission, HLEC were taken from 20 Vatta Predominant,20 Pitta Predominant and 20 Kapha Predominant Prakriti individuals of cataract after cataract surgery and from 4 controls in which quantitative assessment of DNA damage were measured using CometScore™ software. The formation of “comets” in the DNA of lens epithelial cells can be visualized through the method of single gel electrophoresis and indicates DNA strand breaks, as the damaged DNA migrates at a different rate than non-damaged DNA during electrophoresis.
Results: No such prominent comets were indicating any DNA damage in the HLEC of the four control subjects, but comets were found in cataractous HLEC. The maximal damage was found in pitta-predominant Prakriti Individuals. In senile cataract patients, in HLECs DNA was randomly damaged and this type of damage was possible by reactive oxygen species. The DNA damage in HLEC was found maximally in pitta Predominant Prakriti individuals of senile type of cataract patients. Statistical significance was observed between senile cataracts in pitta predominant Prakriti versus senile cataracts in Vata predominant Prakriti individuals and between senile cataracts in Vata predominant Prakriti versus senile cataracts in Kapha Prakriti individual. No statistically significant results were obtained for senile cataracts in pitta Prakriti versus senile cataracts in Kapha Prakriti individuals.
Conclusion: The pathogenesis of senile cataracts is multifactorial and includes continuous molecular stress brought by photo-oxidative stress, UV irradiation, and oxidative reactions.
EVALUATION OF POTENTIALLY HAZARDOUS CONTAMINANTS IN ANTI-VIRAL HERBAL PRODUCTS USED IN CLINICAL PRACTICE
Authors: Kazi Sarfaraz , Bais Sanjay
Published: March 2023

Objective: The main objective of this research was to collect information for consumers and practitioners of marketed non-registered preparations. According to the World Health Organization (WHO) (1998), only arsenic, cadmium, and lead have maximum acceptable concentrations in starting materials of 1.0, 0.3, and 10 ppm, respectively. The allowable limits for toxic heavy metals in raw herbal medicines (ppm) according to the WHO (2007) are 0.5, 2 ppm for mercury and chromium.
Methods: The use of an atomic absorption spectrophotometer was used to determine the buildup of heavy metals such as arsenic (As), chromium (Cr), lead (Pb), mercury (Hg), and cadmium (CD) in commercialized formulations in India. A total of ten samples of herbal formulations containing Swertia chirata, Triphala, Haridra, Daruharidra, Kantakari, Brhati, Karcura, Sunthi, Marica, and Pippali were selected for this research.
Results: The results of this survey show that levels of heavy metals exceeding the limits allowed in unlicensed herbal preparations marketed have been found in the plant-based formulations studied. The herbal formulations coded AV1, AV2, AV7, and AV8 were found to be contaminated by arsenic (As) and in AV2, AV4, AV6, AV7, AV8, and AV9 were found to be contaminated by lead (Pb) levels. Herbal formulations coded AV1, AV2, AV3, AV4, AV6, AV7, AV8, and AV9 were found to be contaminated by mercury level and chromium level was AV1, AV2, AV3, AV4, AV5, AV6, AV7, AV8, AV9, and AV10.
Conclusion: This work shows that the heavy metal content has been found in plant-based formulations. Because these formulations accumulate in the body, they can damage the delicate organs of the patient.
ROLE OF MELATONIN IN ATTENUATION OF HAEMODYNAMIC RESPONSES TO LARYNGOSCOPY AND INTUBATION IN GENERAL ANAESTHESIA
Authors: SOUPARNIKA SR  , SANTHI KS  , SUSAN T CHEERAN
Published: March 2023

Objective: The aim of the study was to study the effects of melatonin in attenuation of hemodynamic responses such as heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean blood pressure (MBP) to laryngoscopy and intubation (L&I) in general anesthesia.
Methods: This was a prospective and observational study conducted in a tertiary care teaching hospital on 120 patients aged 20–45 years belonging to American Society of Anaesthesiologists Grade I, undergoing elective surgery under general anesthesia. Selected patients were allotted into Group A (control group) and Group B (patients who took tablet melatonin 6 mg, 120 min before induction) of 60 patients each. Hemodynamic parameters such as HR, systolic, diastolic, and MBPs were recorded before the administration of drug (baseline), 120 min after administration of study drug (just before induction), immediately after induction, at L&I, just after L&I and at 1, 3, 5, and 10 min thereafter.
Results: The gender distribution and mean age of both groups were comparable. Both the groups were also comparable with respect to baseline values of HR, systolic, diastolic, and mean arterial pressure. The control group showed significant increases in HR, SBP, DBP, and mean arterial blood pressure after L&I and this increase persisted for the next 10 min. In the melatonin group, there was no significant increase in HR, systolic, diastolic, or MBP at any point of measurement after L&I.
Conclusion: Pre-treatment with 6 mg oral melatonin 120 min before induction of anesthesia is effective for attenuating hemodynamic responses to L&I without significant side effects.
EFFECT OF NEBULISED DEXMEDETOMIDINE ON HEMODYNAMIC RESPONSE TO INTUBATION
Authors: NEEMA ANN SABU  , REGIMOL V VARGHESE  , SUSAN T CHEERAN
Published: March 2023

Objective: The aim of the study was to determine the role of nebulized dexmedetomidine in attenuating the stress response to laryngoscopy and intubation and to observe any adverse effects of the drug such as cough, bradycardia, hypotension, and dose-sparing result of propofol.
Methods: A prospective and observational study was conducted in a tertiary care teaching hospital for 12 months. A total of 62 patients (ASA 1 and 2) in the age group of 18–65 years scheduled for elective surgery under general anesthesia received either nebulized dexmedetomidine 10 min before intubation (Group A) or Inj. Lignocaine 90 s before intubation (Group B). Post-intubation hemodynamic parameters were compared in both groups. Data collected remained analyzed using SPSS version 16.
Results: Both groups were comparable with respect to demographic variables. Nebulization with Inj. Dexmedetomidine showed statistically significant blunting of hemodynamic response in the 1st min following intubation, in Group A. This was seen in the variables such as heart rate, diastolic blood pressure, and mean arterial blood pressure. There was no significant difference in the systolic blood pressure at all points of time. Furthermore, there was no significant change in the variables at 5 and 10 min following intubation. There was a significant decrease in the dose of propofol required for induction in Group A compared to Group B.
Conclusion: Nebulization with dexmedetomidine before laryngoscopy and intubation significantly reduced the hemodynamic response to intubation, immediately after intubation.
Integration of DICTs in Education: The Educational Demand Faced with the Profiles of Immigrants and Digital Natives
Authors: Lopes Francisco das Chagas , Souza Walber Gonçalves de , Santana Marival Baldoino de , Ferreira Raquel Carvalho , Souza Márcio Coutinho de , Alves Wederson Marcos , Silva Daniel Rodrigues
Published: March 2023

Proposes here in this work that the implementation and use of TDIC”, necessarily, need to be absorbed by teachers and that for this to happen it is important to have an adequate understanding of their role as a mediator of knowledge and not a supplier; that there is a need for understanding that the saboteur positions that many teachers have is due to their paradigmatic positions and that it is important to understand this dysfunctional maladaptive condition through a cognitive restructuring so that their role as a mediator of knowledge is understood. That done, these digital immigrant teachers must be inserted in intensive training policy to know the tools of TDIC”s and be able to adapt their new role in the mediation between information and their native digital students. These, in turn, need to be “educated” about the use of digital information and communication technologies not only as an instrument of chatting or games, without a mediating application of knowledge.
ОБЗОР ПРОДУКЦИИ КОМПАНИИ SIT
Authors: Садеков Д.
Published: March 2023

Китайская компания Silicon Internet of Things Technology (SIT) специализируется на производстве интерфейсных микросхем для автомобильных и промышленных применений. В статье представлен обзор основных категорий и серий продуктов, выпускаемых компанией SIT, их ключевые сферы применения.
ИСТОРИЯ РАДИОЧАСТОТНЫХ СОЕДИНИТЕЛЕЙ. СОЕДИНИТЕЛИ ОБЩЕГО ПРИМЕНЕНИЯ. ЧАСТЬ 2
Authors: Джуринский К.
Published: March 2023

Основными направлениями развития радиочастотных соединителей являются: продвижение в область более высоких частот, миниатюризация, повышение надежности, улучшение основных параметров. Рассматриваются соединители мм-диапазона: 2.4 mm (предельная частота 50 ГГц), 1.85 mm (65 ГГц), 1.0 mm (110 ГГц), 1.35 mm (90 ГГц), 0.8 mm (145 ГГц).
АНТЕННЫЕ ПЕРЕКЛЮЧАТЕЛИ. ЧАСТЬ 6
Authors: Кочемасов В. , Сафин А. , Дингес С.
Published: March 2023

Рассмотрены антенные переключатели. Приведена информация об особенностях и характеристиках различных типов таких устройств, выпускаемых рядом производителей.
НАСТОЛЬНАЯ АВТОМАТИЧЕСКАЯ УСТАНОВКА МОНТАЖА ЗОЛОТОЙ ПРОВОЛОКИ МЕТОДОМ «ШАРИК-КЛИН»
Authors: Петухов И. , Летунович Е.
Published: March 2023

Описана настольная автоматическая установка термозвуковой микросварки для монтажа золотых проволочных выводов диаметром от 17,5 до 50 мкм, имеющая систему автоматического совмещения рабочего инструмента с разноуровневыми контактными площадками и прецизионную трехосевую координатную систему на основе сервоприводов. Установка обеспечивает автоматический монтаж выводов по предварительно занесенным в память координатам точек межсоединений.
ВАКУУМПЛОТНАЯ ГЕРМЕТИЗАЦИЯ МИКРОБОЛОМЕТРОВ
Authors: Видрицкий А. , Ланин В.
Published: March 2023

В статье описана разработка технологии герметизации корпусов микроболометров. Герметизация производится в высоком вакууме с использованием геттера, чем обеспечивается сохранение заданного уровня вакуума внутри корпуса микромеханического прибора в течение срока хранения и эксплуатации.
ОЦЕНКА СТАБИЛЬНОСТИ И ВОСПРОИЗВОДИМОСТИ ТЕХНОЛОГИЧЕСКОГО ПРОЦЕССА МЕТАЛЛИЗАЦИИ ЧЕРЕЗ СВОБОДНУЮ МАСКУ
Authors: Почтарь О. , Почтарь А.
Published: March 2023

В статье на основе статистической обработки экспериментальных данных представлена оценка стабильности и воспроизводимости технологического процесса двухслойной металлизации кристаллов ниобата лития через свободную металлическую маску методом электронно-­лучевого испарения.
ХАРАКТЕРИСТИКИ КРЕМНИЕВЫХ КАНТИЛЕВЕРОВ ДЛЯ АТОМНО-­СИЛОВОЙ МИКРОСКОПИИ КОМПАНИИ АО «АНГСТРЕМ»
Authors: Новак А. , Соколов А. , Ковалев В.
Published: March 2023

Представлены результаты измерения основных параметров кремниевых кантилеверов производства АО «Ангстрем», предназначенных для работы в полуконтактном и контактном режимах атомно-­силовой микроскопии (АСМ), а также АСМ-изображения различных образцов, полученные при помощи этих кантилеверов.
ЭЛЕКТРОЛИТИЧЕСКОЕ АНОДИРОВАНИЕ КРЕМНИЯ, КАРБИДА И НИТРИДА КРЕМНИЯ ДЛЯ ЦЕЛЕЙ НАНОТЕХНОЛОГИИ (ОБЗОР)
Authors: Махаринец А. , Милешко Л.
Published: March 2023

Представлен анализ технологий формирования нанометровых анодных оксидных пленок (АОП) методом электролитического анодирования кремния, карбида и нитрида кремния. Приведены примеры использования таких технологий в микро- и наноэлектронике.
Управление твердостью поверхностного слоя титановых образцов за счет аддитивной лазерной обработки
Authors: Егорова К.А. , Розанов К.А. , Киян А.И. , Синев Д.А.
Published: March 2023

Представлены результаты
экспериментальных исследований
по подбору оптимальных параметров
лазерного излучения для повышения
твердости и износостойкости модельного
титанового образца. Работа проведена
с целью поиска возможностей управления
механическими и функциональными
параметрами титана методом аддитивной
лазерной микрообработки поверхности
под вспомогательным слоем графита при
воздействии лазерного излучения ближнего
ИК-диапазона. Результаты испытаний
демонстрируют повышение твердости
поверхностного слоя обработанного титана
в 9,3 раз и снижение скорости абразивного
изнашивания по сравнению с исходным
образцом примерно в 2 раза.
Ионизация Ca при сонолюминесценции водного раствора CaCl2
Authors: Гордейчук Т.В. , Козачек М.В.
Published: March 2023

При облучении ультразвуком 20 кГц в спектре многопузырьковой СЛ 2 M водного
раствора CaCl2 наблюдались слабые линии иона CaII при 393 и 397 нм. Сравнение
со спектром Солнца позволяет сделать грубую оценку степени ионизации Ca,
которая свидетельствует о существенной термодинамической неравновесности
процессов в кавитационном пузырьке.
Nudo verdadero de cordón umbilical, hallazgo incidental al nacimiento. Reporte de 4 casos en un hospital de tercer nivel.
Authors: Arriaga López Alberto , Álvarez Torres Alfredo , Leyva Díaz Andrea , Cuevas Arellano Gladys Georgina , Chavira Anaya Cynthia Fabiola
Published: March 2023

The true umbilical cord knot is a pathology with an incidence relatively low. It is associated with the risk of loss of fetal well-being and stillbirth. There are both maternal and fetal risk factors, with different associated perinatal outcomes. Prenatal diagnosis of a true knot is a diagnostic challenge for the obstetrician, however, nowadays it is possible by ultrasound for incidental finding or by intentional search, mainly in patients with risk factors. In the same way it should be suspected in the presence of a non-reassuring cardiotocography, especially when there is no response to the usual intrauterine resuscitation maneuvers, such as left lateral decubitus position, supplemental oxygen and maternal hydration. The purpose of this report is to describe 4 cases of true knot in term pregnancies, in a third level hospital, where an incidence of 0.03% was estimated, with a mean gestational age of 39.3 weeks and a mean maternal age of 32.2 years. The main intrapartum findings were alterations in the cardiotocography, such as variable and late decelerations. The route of pregnancy resolution was equitable among the patients, 2 were resolved by vaginal delivery and the other 2 by cesarean section. Pregnancy was resolved by vaginal delivery in 2 of the patients, while the other 2 were resolved by cesarean section. One case of stillbirth was registered Keywords: Umbilical cord; true knot; perinatal outcomes; prenatal diagnosis.
Seaweed Utilizing as a Biostimulants in Agriculture Sector: A Review
Authors: Pandya Megha , Mehta Shailesh
Published: March 2023

Abstract: The marine environment depends on seaweed, which is abundant in the water and plays an essential and crucial function in it. Many researchers have been studying seaweed for more than seven decades. According to our needs, research has been done separately in different aspects. There are several chemical fertilisers commercially available today, but they significantly reduce or harm soil fertility, growth, and yield. The amount of fertiliser needed by the plant or crop will determine the fertility of the soil. When compared to terrestrial foods, the seaweed fertilisers had a lot of nutrients including nitrogen, phosphate, potassium, and important vitamins. They also helped to improve biochemical components like proteins, lipids, polysaccharides, enzymes, and plant growth hormones and trace elements. Finally, this paper would be helpful to a common man and farmers to know and aware about such a great living resource which is present in and around us and their agricultural products are beneficial to our society.
Análisis de la implementación del modelo de turismo rural comunitario desde el enfoque de bienes de capital rural en tres regiones del sur de Perú.
Authors: Vargas-Cárdenas Tonantzin , Thomé-Ortiz Humberto , Ávalos de la Cruz Dora Angélica , Gómez Merino Fernando Carlos
Published: March 2023

El objetivo de la investigación fue identificar las interrelaciones entre el Modelo de Turismo Rural Comunitario (TRC) del Ministerio de Comercio Exterior y Turismo de Perú y el marco de bienes de capital rural, a partir de la capacidad de las comunidades para generar estrategias de desarrollo territorial. Se estudiaron nueve comunidades rurales que han desarrollado el modelo de TRC con éxito en tres regiones turísticas del sur del Perú: Cusco, Puno y Arequipa. Se aplicaron 45 entrevistas a personas dedicadas a labores de agricultura, artesanía, alojamiento, guías turísticos, gastronomía y promotores de difusión; así como a dueños de emprendimientos y autoridades municipales. Los resultados indican que cuatro comunidades han logrado generar las estrategias turísticas del modelo, dos comunidades han perdido la visión del tejido social y la cadena de valor de TRC, dos comunidades más tienen dificultad con la accesibilidad al lugar y falta de promoción turística; y una última comunidad comienza a desarrollar el TRC. Se concluye que la actividad socioeconómica del capital rural del modelo TRC permite el desarrollo local y el bienestar de las familias rurales en el Perú.
Cumplimiento de la sentencia Gelman vs. Uruguay de la Corte Interamericana de Derechos Humanos. Especial referencia al punto resolutivo 11 y al Poder Judicial
Authors: Risso Ferrand Martín , Martínez Carlis Eloísa , Brun Pereira Martina , Charamelo Ignielzi Blanca , Furtado Álvarez Belén , Mendina Martínez Camila , Rodríguez Fernández Ayelén , Tucuna Boada Florencia
Published: March 2023

Luego de más de once años de dictada la sentencia de la Corte Interamericana de Derechos Humanos (Corte IDH) en el caso Gelman, se procede a estudiar cómo ha sido el cumplimiento de dicha sentencia frente al Poder Judicial y cómo ha influido dicho pronunciamiento internacional en la jurisprudencia nacional. Se aprecian vaivenes en la jurisprudencia hasta encontrar o aproximarse a una suerte de sintonía entre las jurisdicciones nacional e internacional.
Parity Quantum Optimization: Compiler
Authors: Ender Kilian , ter Hoeven Roeland , Niehoff Benjamin E. , Drieb-Schön Maike , Lechner Wolfgang
Published: March 2023

We introduce parity quantum optimization with the aim of solving optimization problems consisting of arbitrary k-body interactions and side conditions using planar quantum chip architectures. The method introduces a decomposition of the problem graph with arbitrary k-body terms using generalized closed cycles of a hypergraph. Side conditions of the optimization problem in form of hard constraints can be included as open cycles containing the terms involved in the side conditions. The generalized parity mapping thus circumvents the need to translate optimization problems to a quadratic unconstrained binary optimization problem (QUBO) and allows for the direct encoding of higher-order constrained binary optimization problems (HCBO) on a square lattice and full parallelizability of gates.
Агаарын радоноос хүний жилд авах тунг тодорхойлох нь
Authors: Б Эрдэв , М Чадраабал , Б Мөнхцэцэг
Published: March 2023

Энэхүү ажлыг МУИС-ийн ЦСТ-ийн бага цацраг бүртгэх лабораторид хийсэн бөгөөд агаарын радоноос хүний жилд авах тунг сцинтилляцийн аргаар радоныг тодорхойлох замаар тооцоолон гаргасан үр дүнг дэлхийн улсуудын үр дүнтэй харьцуулан зөвшөөрөх утгатай жишсэн тухай өгүүлнэ.
Харьцангуйн Ерөнхий Онол
Authors: M Д. Дамбасүрэн
Published: March 2023

Харьцангуйн Ерөнхий Онол
Устөрөгчийн атомыг лазерын пульсээр өдөөх магадлалыг Борны нэгдүгээр эрэмбийн ойролцоололд бодох нь
Authors: Ч Алдармаа , Л Хэнмэдэх , О Лхагва
Published: March 2023

Устөрөгчийн атомыг лазерын богино пульсээр өдөөх магадлалыг Борны 1-р эрэмбийн ойролцооллоор бодож, лазерын пульсын хэлбэр устөрөгчийн атомын өдөөгдөх магадлалд нөлөөлөх нөлөөг судлав.
Материалы: Свойства И Возможные Применения
Authors: M Э.М. Шпилевский , С.А. Филатов  , Шилагарди Г. , Тувшинтур П. , А. Т. Богорош  , Ц. Хандмаа  , Р. Нямдулам
Published: March 2023

Материалы: Свойства И Возможные Применения
Гелийн атомын фотоэлектроны голограф
Authors: Ч Алдармаа , Г Зоригт , Л Хэнмэдэх
Published: March 2023

Гелийн атомыг лазерын богино хүчтэй пульсээр иончлох процессыг Кулоны долгион функцын дискрет хувьсагчийн арга (CWDVR) ашиглан хувьсах эффектив цэнэгтэйгээр хугацаанаас хамаарсан Шредингерийн тэгшитгэлийг тоон аргаар бодлоо. Шугаман туйлшралтай лазерын богино хүчтэй пульсээр гелийн атомыг үйлчлэхэд сугаран гарч буй фотоэлектроны импульсын түгэлт буюу голографын дүрслэлийг гарган авсан.
Даралтын нөлөөнд чулуулаг дээжний кристалл бүтцэд үүсэх үлдэгдэл хэв гажилт болон текстур бүтцийг нисэлтийн хугацааны нейтрон дифракцын аргаар судалсан үр дүн
Authors: А Бадмаараг , К Шеффцюк , Д Сангаа , Б Мюллер , Ф Шиллинг , Л Энхтөр
Published: March 2023

Газрын гүний байгууламжийн эргэн тойронд үүсч буй механик хүч, температур зэрэг байгалын хүчин зүйлсийн нөлөөнд орж, кристалл бүтцийн эгэл тордоо эвдрэл, хэв гажилт үүссэн поликристалл метаморф хувьрал бүхий чулуулаг дээжний бүтцийн текстур шинж чанар болон хэв гажилтын судалгааг нисэлтийн хугацааны (TOF) нейтрон дифракцын аргаар судалсан болно. Туршилтыг ОХУ-ын Дубна хот дахь ЦШНИ-ийн ИБР-2М импульст нейтроны үүсгүүрийн 7–р сувагт байрлах SKATEPSILON нейтрон дифрактометрүүд болон тэдгээрийн дагалдах нэмэлт төхөөрөмжүүдийг ашиглан гүйцэтгэв. Эгэл торын хэв гажилтыг тодорхойлохын тулд нэг тэнхлэгийн дагуу 53 МРа хүртэл даралтын нөлөөлөл үүсгэн тухайн даралтын чиглэлийн дагуу 10 мм–ийн алхамтайгаар шилжүүлэн хэмжсэн хэмжилтийн үр дүнд поликристалл дээжний хамгийн өндөр хэв гажилтанд орж буй кварц фазын үлдэгдэл хэв гажилт нь суналтын мужид хамгийн багадаа -1.6 ∙ 10-3 ба түүнд перпендикуляр чиглэл дэх шахалтын мужид хамгийн ихдээ 1.2 ∙ 10-3 байгааг тодорхойлов.
Физические и физико-химические свойства металл-фуллереновых пленок, полученных вакуумными технологиями
Authors: П Тувшинтур , Д Улам-Оргих , Э.М. Шпилевский , С.А. Филатов , Г. Шилагарди
Published: March 2023

Показано, что введение в пленки фуллеренов даже в небольших долях (до 1.0 мас.%) существенно (в некоторых случаях в разы) изменяет их физические и физикохимические свойства. Особо сильную зависимость испытывают трибологические, электрические и термоэлектрические свойства.