bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure S3 from Genomic Profiling of Radiation-Induced Sarcomas Reveals the Immunologic Characteristics and Its Response to Immune Checkpoint Blockade
Authors: Hong Dong-Chun , Yang Jing , Sun Cong , Liu Yuan-Tao , Shen Lu-Jun , Xu Bu-Shu , Que Yi , Xia Xiaojun , Zhang Xing
Published: August 2023

Comparison between RIS group and SARC group in mRNA-seq and WES data.(A) Expression levels of IDO and CTLA-4 in the RIS group and SARC group in mRNA-seq.(B) The anti-tumor immunity score and the proliferation module score of the RIFS group and the RIOS group.(C) The comparison of the anti-tumor immunity score and the proliferation module score between subtypes RIFS vs FS and between RIOS vs OS.(D) Mutation summary of WES data in the RIS and SARC groups.(E) Top 50 mutated genes in RIFS, FS, RIOS and OS subtype groups.
Supplementary Table S2 from Early On-treatment Changes in Circulating Tumor DNA Fraction and Response to Enzalutamide or Abiraterone in Metastatic Castration-Resistant Prostate Cancer
Authors: Tolmeijer Sofie H. , Boerrigter Emmy , Sumiyoshi Takayuki , Kwan Edmond M. , Ng Sarah W.S. , Annala Matti , Donnellan Gráinne , Herberts Cameron , Benoist Guillemette E. , Hamberg Paul , Somford Diederik M. , van Oort Inge M. , Schalken Jack A. , Mehra Niven , van Erp Nielka P. , Wyatt Alexander W.
Published: August 2023

Evidence for ctDNA estimates per patient per timepoint
Supplementary Figure S7 from Early On-treatment Changes in Circulating Tumor DNA Fraction and Response to Enzalutamide or Abiraterone in Metastatic Castration-Resistant Prostate Cancer
Authors: Tolmeijer Sofie H. , Boerrigter Emmy , Sumiyoshi Takayuki , Kwan Edmond M. , Ng Sarah W.S. , Annala Matti , Donnellan Gráinne , Herberts Cameron , Benoist Guillemette E. , Hamberg Paul , Somford Diederik M. , van Oort Inge M. , Schalken Jack A. , Mehra Niven , van Erp Nielka P. , Wyatt Alexander W.
Published: August 2023

On-treatment ctDNA fraction, PSA responses and baseline genomic and clinical features
Supplementary Figure S3 from Early On-treatment Changes in Circulating Tumor DNA Fraction and Response to Enzalutamide or Abiraterone in Metastatic Castration-Resistant Prostate Cancer
Authors: Tolmeijer Sofie H. , Boerrigter Emmy , Sumiyoshi Takayuki , Kwan Edmond M. , Ng Sarah W.S. , Annala Matti , Donnellan Gráinne , Herberts Cameron , Benoist Guillemette E. , Hamberg Paul , Somford Diederik M. , van Oort Inge M. , Schalken Jack A. , Mehra Niven , van Erp Nielka P. , Wyatt Alexander W.
Published: August 2023

Oncoprint showing the copy number alterations, structural variants and mutations per patient at baseline
Supplementary Tables 1-8 from Alternating 17β-Estradiol and Aromatase Inhibitor Therapies Is Efficacious in Postmenopausal Women with Advanced Endocrine-Resistant ER+ Breast Cancer
Authors: Schwartz Gary N. , Kaufman Peter A. , Giridhar Karthik V. , Marotti Jonathan D. , Chamberlin Mary D. , Arrick Bradley A. , Makari-Judson Grace , Goetz Matthew P. , Soucy Shannon M. , Kolling Fred , Demidenko Eugene , Miller Todd W.
Published: August 2023

Suppl. Tables S1-S8
Supplementary Fig. 1 from Alternating 17β-Estradiol and Aromatase Inhibitor Therapies Is Efficacious in Postmenopausal Women with Advanced Endocrine-Resistant ER+ Breast Cancer
Authors: Schwartz Gary N. , Kaufman Peter A. , Giridhar Karthik V. , Marotti Jonathan D. , Chamberlin Mary D. , Arrick Bradley A. , Makari-Judson Grace , Goetz Matthew P. , Soucy Shannon M. , Kolling Fred , Demidenko Eugene , Miller Todd W.
Published: August 2023

Supplementary Fig. 1 CONSORT flow diagram of study patients. Among the 23 patients consented for study participation, 19 were considered evaluable.
Figure S8 from Subsets of IFN Signaling Predict Response to Immune Checkpoint Blockade in Patients with Melanoma
Authors: Horowitch Brooke , Lee Daniel Y. , Ding Min , Martinez-Morilla Sandra , Aung Thazin Nwe , Ouerghi Feriel , Wang Xueting , Wei Wei , Damsky William , Sznol Mario , Kluger Harriet , Rimm David L. , Ishizuka Jeffrey J.
Published: August 2023

Supplementary Figure 8: Members of the interferon signaling pathway and ICI treatment regimen predict survival in Gide et al
Figure S5 from Subsets of IFN Signaling Predict Response to Immune Checkpoint Blockade in Patients with Melanoma
Authors: Horowitch Brooke , Lee Daniel Y. , Ding Min , Martinez-Morilla Sandra , Aung Thazin Nwe , Ouerghi Feriel , Wang Xueting , Wei Wei , Damsky William , Sznol Mario , Kluger Harriet , Rimm David L. , Ishizuka Jeffrey J.
Published: August 2023

Supplementary Figure 5: STAT1, pSTAT1Y701, and PD-L1 have similar baseline expression and impact on survival between tissue types
Figure S4 from Subsets of IFN Signaling Predict Response to Immune Checkpoint Blockade in Patients with Melanoma
Authors: Horowitch Brooke , Lee Daniel Y. , Ding Min , Martinez-Morilla Sandra , Aung Thazin Nwe , Ouerghi Feriel , Wang Xueting , Wei Wei , Damsky William , Sznol Mario , Kluger Harriet , Rimm David L. , Ishizuka Jeffrey J.
Published: August 2023

Supplemental Figure 4: STAT1 in the nuclear compartment consistently predicts ICI response and survival but not nuclear pSTAT1Y701 or tumor/stromal PD-L1
Figure S3 from Subsets of IFN Signaling Predict Response to Immune Checkpoint Blockade in Patients with Melanoma
Authors: Horowitch Brooke , Lee Daniel Y. , Ding Min , Martinez-Morilla Sandra , Aung Thazin Nwe , Ouerghi Feriel , Wang Xueting , Wei Wei , Damsky William , Sznol Mario , Kluger Harriet , Rimm David L. , Ishizuka Jeffrey J.
Published: August 2023

Supplemental Figure 3: STAT1 in the tumor compartment consistently predicts ICI response and survival but not stromal STAT1 or tumor/stromal pSTAT1Y701
Supplementary Fig. 2 from An Open-label Phase I Study of GDC-0927 in Postmenopausal Women with Locally Advanced or Metastatic Estrogen Receptor–Positive Breast Cancer
Authors: Chandarlapaty Sarat , Dickler Maura N. , Perez Fidalgo Jose Alejandro , Villanueva-Vázquez Rafael , Giltnane Jennifer , Gates Mary , Chang Ching-Wei , Cheeti Sravanthi , Fredrickson Jill , Wang Xiaojing , Collier Ann , Moore Heather M. , Metcalfe Ciara , Lauchle Jennifer , Humke Eric W. , Bardia Aditya
Published: August 2023

Supplementary Fig. S2. The PGR z-score for six patients analyzed in Fig. 4.
Supplementary Fig. 1 from An Open-label Phase I Study of GDC-0927 in Postmenopausal Women with Locally Advanced or Metastatic Estrogen Receptor–Positive Breast Cancer
Authors: Chandarlapaty Sarat , Dickler Maura N. , Perez Fidalgo Jose Alejandro , Villanueva-Vázquez Rafael , Giltnane Jennifer , Gates Mary , Chang Ching-Wei , Cheeti Sravanthi , Fredrickson Jill , Wang Xiaojing , Collier Ann , Moore Heather M. , Metcalfe Ciara , Lauchle Jennifer , Humke Eric W. , Bardia Aditya
Published: August 2023

Supplementary Fig. S1. Study scheme.
Supplementary Figure S3 from HLA Class II Loss and JAK1/2 Deficiency Coevolve in Melanoma Leading to CD4 T-cell and IFNγ Cross-Resistance
Authors: Stupia Simone , Heeke Christina , Brüggemann Alicia , Zaremba Anne , Thier Beatrice , Kretz Julia , Sucker Antje , Philip Manuel , Zelinskyy Gennadiy , Ferrone Soldano , Roesch Alexander , Horn Susanne , Hadaschik Eva , Schadendorf Dirk , Trilling Mirko , Dittmer Ulf , Griewank Klaus , Zhao Fang , Paschen Annette
Published: August 2023

ConstHLA-II melanoma cells lack endogenous interferon expression
Supplementary Fig. 6 from Antitumor Efficacy of the Novel KIT Inhibitor IDRX-42 (Formerly M4205) in Patient- and Cell Line–Derived Xenograft Models of Gastrointestinal Stromal Tumor (GIST)
Authors: De Sutter Luna , Wozniak Agnieszka , Verreet Jasper , Vanleeuw Ulla , De Cock Lore , Linde Nina , Drechsler Christine , Esdar Christina , Sciot Raf , Schöffski Patrick
Published: August 2023

Supplementary Fig. 6. One histologically representative picture of cPARP staining in control group versus IDRX-42_25 treatment group in the experiment with UZLX-GIST9KIT11+17.
Supplementary Fig. 2 from Antitumor Efficacy of the Novel KIT Inhibitor IDRX-42 (Formerly M4205) in Patient- and Cell Line–Derived Xenograft Models of Gastrointestinal Stromal Tumor (GIST)
Authors: De Sutter Luna , Wozniak Agnieszka , Verreet Jasper , Vanleeuw Ulla , De Cock Lore , Linde Nina , Drechsler Christine , Esdar Christina , Sciot Raf , Schöffski Patrick
Published: August 2023

Supplementary Fig. 2. Individual absolute tumor volumes per experiment and per treatment group on the first and last day of experiment.
Supplementary Fig. 1 from Antitumor Efficacy of the Novel KIT Inhibitor IDRX-42 (Formerly M4205) in Patient- and Cell Line–Derived Xenograft Models of Gastrointestinal Stromal Tumor (GIST)
Authors: De Sutter Luna , Wozniak Agnieszka , Verreet Jasper , Vanleeuw Ulla , De Cock Lore , Linde Nina , Drechsler Christine , Esdar Christina , Sciot Raf , Schöffski Patrick
Published: August 2023

Supplementary Fig. 1. Histopathological characteristics.
Figure S5 from Immunogenomic Landscape of Neuroendocrine Prostate Cancer
Authors: Bhinder Bhavneet , Ferguson Alison , Sigouros Michael , Uppal Manik , Elsaeed Ahmed G. , Bareja Rohan , Alnajar Hussein , Eng Kenneth Wha , Conteduca Vincenza , Sboner Andrea , Mosquera Juan Miguel , Elemento Olivier , Beltran Himisha
Published: August 2023

Suppl Figure 5. Comparative analysis between NEPC and SCLC.
Figure S4 from Immunogenomic Landscape of Neuroendocrine Prostate Cancer
Authors: Bhinder Bhavneet , Ferguson Alison , Sigouros Michael , Uppal Manik , Elsaeed Ahmed G. , Bareja Rohan , Alnajar Hussein , Eng Kenneth Wha , Conteduca Vincenza , Sboner Andrea , Mosquera Juan Miguel , Elemento Olivier , Beltran Himisha
Published: August 2023

Suppl Figure 4. TME profile of distinct prostate cancer types in the cohort.
Supplementary Table 2 from Gemcitabine, Docetaxel, Capecitabine, Cisplatin, Irinotecan (GTX-CI) as First-line Treatment for Metastatic Pancreatic Cancer
Authors: Wilbur H. Catherine , Durham Jennifer N , Lim Su Jin , Purtell Katrina , Bever Katherine M. , Laheru Daniel A. , De Jesus-Acosta Ana , Azad Nilofer S. , Wilt Bradley , Diaz Luis A. , Le Dung T. , Wang Hao
Published: August 2023

Supplementary Table 2: Related Adverse Events
Supplementary Figure 1 from Gemcitabine, Docetaxel, Capecitabine, Cisplatin, Irinotecan (GTX-CI) as First-line Treatment for Metastatic Pancreatic Cancer
Authors: Wilbur H. Catherine , Durham Jennifer N , Lim Su Jin , Purtell Katrina , Bever Katherine M. , Laheru Daniel A. , De Jesus-Acosta Ana , Azad Nilofer S. , Wilt Bradley , Diaz Luis A. , Le Dung T. , Wang Hao
Published: August 2023

Supplementary Figure 1: Consort
TABLE 1 from Immunologic Assessment of Tumors from a Race-matched Military Cohort Identifies Mast Cell Depletion as a Marker of Prostate Cancer Progression
Authors: Schafer Cara C. , Jiang Jiji , Elsamanoudi Sally , Nousome Darryl , Young Denise Y. , Song Yingjie , Sesterhenn Isabell A. , Chesnut Gregory T. , Tan Shyh-Han
Published: August 2023

Cohort summary
Supplementary Figure S5 from Immunologic Assessment of Tumors from a Race-matched Military Cohort Identifies Mast Cell Depletion as a Marker of Prostate Cancer Progression
Authors: Schafer Cara C. , Jiang Jiji , Elsamanoudi Sally , Nousome Darryl , Young Denise Y. , Song Yingjie , Sesterhenn Isabell A. , Chesnut Gregory T. , Tan Shyh-Han
Published: August 2023

Supplementary Figure S5 shows non-significant relative cell type scores by metastasis status.
Supplementary Figure S4 from Immunologic Assessment of Tumors from a Race-matched Military Cohort Identifies Mast Cell Depletion as a Marker of Prostate Cancer Progression
Authors: Schafer Cara C. , Jiang Jiji , Elsamanoudi Sally , Nousome Darryl , Young Denise Y. , Song Yingjie , Sesterhenn Isabell A. , Chesnut Gregory T. , Tan Shyh-Han
Published: August 2023

Supplementary Figure S4 shows non-significant relative cell type scores by GG.
O presente peronista: “espaço de experiência” e “horizonte de expectativa” no discurso populista de Juan Domingo Perón (1946-1955)
Authors: Batista Ana Laura Galvão
Published: August 2023

O presente trabalho analisa a inserção particular do peronismo argentino (1946-1955) no regime de temporalidade moderno concebido pelo historiador Reinhart Koselleck a partir da identificação de dissonâncias temporais próprias do período e que precisavam ser consideradas nos discursos oficiais para se garantir a manutenção da hegemonia populista do regime. Em um primeiro momento, será apresentada uma breve articulação do que consideramos como as contribuições essenciais da metafísica do tempo histórico de Reinhart Koselleck para os estudos temporais, assim como a revisão crítica desse pensamento tradicional desdobrada por Stefan Helgesson no âmbito da historiografia pós-colonial. Nessa perspectiva, em seguida, identificaremos as “heterocronias”, ou seja, as conversões temporais do discurso populista de Juan Domingo Perón nos documentos oficiais, as quais possibilitariam deslocamentos específicos entre o “espaço de experiência” e o “horizonte de expectativa” dos argentinos. Como resultado, identificamos uma temporalidade na qual o presente é destacado como o tempo das mudanças e das realizações sociais, rompendo com um “antes” oligárquico de exploração e cosmopolitismo e se estabelecendo um futuro determinado e planejado pelo “agora” peronista. Tal análise, então, permite-nos conceber a Argentina sob Perón como um exemplo de modernidade alternativa.
Flora Tristan e o sistema de justiça patriarcal: a insurgência de “Peregrinações de uma Pária”
Authors: Duarte Joana das Flores
Published: August 2023

Flora Tristan escreveu Peregrinaciones de una paria [As peregrinações de uma pária] entre 1833-1834. O livro é um relato da sua viagem pelo Peru, em busca do reconhecimento de sua família paterna. O fito desta resenha é o de mostrar a atualidade e insurgência do pensamento de Flora Tristan. Destacamos, entre essas rebeldias, a sua transcendência cronológica ao tempo vivido e os elementos fundantes de uma crítica feminista ao sistema de justiça patriarcal. É partindo de sua experiência matrimonial (da tentativa de desfecho dessa experiência) que Flora explora as determinações patriarcais que se interseccionam com o sistema de justiça. Desvenda, a partir daí a relação de dominação e imposição do casamento, bem como a determinação do “papel feminino” no seio da família. Ao trazer a perseguição chancelada pelo Estado do homem sobre a mulher, Flora afirma a atualidade da sua obra após 188 anos da primeira publicação. Sua insurgência não reside apenas no tratamento analítico dado ao apagamento dos fundamentos filosóficos do direito de liberdade das mulheres, mas na sua arguta apreensão sobre a relação de dominação masculina com a formulação jurídica do direito de propriedade privada burguesa. Flora inaugura como princípio revolucionário que o privado, além de público, é político. Destaca-se a relevância contemporânea de sua obra para a América Latina e o Caribe, em especial no pensamento feminista.
América latina: la trampa para las clases reinantes
Authors: Cueva Perus Marcos
Published: August 2023

Este artículo se propone examinar algunas de las contradicciones sociales en las que se desenvuelven los gobiernos latinoamericanos actuales, en particular los progresistas. A partir de lo que entiende Michel Foucault por “soberanía” y mediante una metodología hipotético-deductiva, se afirma que la región latinoamericana, pese a la penetración capitalista generalizada, conserva rasgos arcaicos no sencillos de desterrar. Habida cuenta de un estado de crisis y de desnacionalización, bajo fuerte influencia estadounidense, ciertas “capas ideológicas y políticas”, no desligadas de las capas medias, podrían haberse visto llamadas a gestionarlo, pero sin cambiar estructuras de raíz, en un tipo de proceso que ya ha ocurrido antes en la historia. Desde este punto de vista, sigue siendo importante distinguir entre clase dirigente y “clase reinante”, y recordar que “progresismo”, a fin de cuentas, no es sinónimo de acceso de los sectores populares al poder, sobre todo en sociedades polarizadas.
Resumo: Este artigo pretende examinar algumas das contradições sociais nas quais operam os atuais governos latino-americanos, particularmente os progressistas. Partindo do que Michel Foucault entende por “soberania” e por meio de uma hipotética metodologia dedutiva, afirma-se que a região latino-americana, apesar da penetração capitalista generalizada, preserva traços arcaicos que não são fáceis de banir. Dado um estado de crise e desnacionalização, sob forte influência dos EUA, na crise, certas "camadas ideológicas e políticas", não desvinculadas das camadas médias, poderiam ter sido chamadas a geri-la, mas sem alterar as estruturas de raiz, de uma forma processo que já aconteceu antes na história. Desse ponto de vista, ainda é importante distinguir entre classe dominante e “classe reinante”, e lembrar que “progressismo”, afinal, não é sinônimo de acesso ao poder para os setores populares, especialmente em sociedades polarizadas .
 
Abstract: This article intends to examine some of the social contradictions in which current Latin American governments operate, particularly the progressive ones. Starting from what Michel Foucault understands by “sovereignty” and through a hypothetical deductive methodology, it is affirmed that the Latin American region, despite the generalized capitalist penetration, preserves archaic features that are not easy to banish. Given a state of crisis and denationalization, under strong US influence, in the crisis, certain "ideological and political layers", not detached from the middle layers, could have been called upon to manage it, but without changing root structures, in a kind of process that has happened before in history. From this point of view, it is still important to distinguish between the ruling class and the “class which reigns”, and to remember that “progressivism”, after all, is not synonymous with access to power for the popular sectors, especially in polarized societies.
“El marxismo dará salud a los enfermos”: ideia-chave da medicina social latino-americana
Authors: Souza Diego de Oliveira
Published: August 2023

Neste artigo, analisamos a tela “El marxismo dará salud a los enfermos” (1954), de autoria da mexicana Frida Kahlo. Metodologicamente, procedemos conforme a proposta de análise imanente, considerando a perspectiva estética lukacsiana. Iniciamos com uma breve descrição da trajetória de Frida, com destaque para a obra em análise. Em seguida, realizamos analogias com premissas da Medicina Social Latino-americana, destacando três aspectos decisivos da determinação social da saúde: o caráter ontológico, a natureza dialética e o horizonte político. Destacamos que, tanto na obra de Frida quanto nos principais autores da Medicina Social Latino-americana (ambos influenciados pelo marxismo), está presente a ideia-chave de que a saúde, no capitalismo, consiste em manifestação do antagonismo entre capital e trabalho. Essa ideia-chave representa, pois, a síntese entre singularidades, particularidades e universalidade; assim como a articulação orgânica entre as esferas biológica e social, o que pressupõe certo caráter político, no sentido das respostas que essa articulação suscita e do horizonte de transformação da saúde, em suas múltiplas dimensões.
Revolução Cubana entre artistas e intelectuais brasileiros: o caso de "Violão de Rua"
Authors: Neves Dédallo
Published: August 2023

Violão de Rua foi uma antologia publicada em três volumes entre os anos 1962 e 1963. Integrou a coleção Cadernos do Povo Brasileiro como volume especial da editora Civilização Brasileira. Com seleção e edição do também poeta Moacyr Félix, o objetivo era popularizar a poesia entre as diferentes camadas sociais. Ao pôr a antologia em diálogo com a Revolução Cubana, será demonstrado como a poesia pode ser ferramenta estruturante de modos de vida e visões de mundo, e como ela está indissoluvelmente associada às dinâmicas e processos sociais, sendo partícipe de uma mesma “estrutura de sentimento”. Considerando a expressividade da Revolução Cubana nos países latino-americanos, o que interessa a este artigo é investigar como ela impactou a produção artística brasileira, particularmente a antologia Violão de Rua, e como esta, por sua vez, tornou-se uma possibilidade de avaliação dos acontecimentos da ilha caribenha, expressando e compartilhando uma consciência prática estruturada a partir da produção e organização material da vida.
Conjunturas críticas, mudanças de ciclos políticos e desdemocratização na Venezuela ao longo dos governos chavistas
Authors: Nascimento Jefferson
Published: August 2023

O presente artigo analisa as transformações sociopolíticas ocorridas na Venezuela desde a chegada de Chávez ao poder, utilizando os conceitos de conjuntura crítica, ciclo político e (des)democratização como ferramentas teóricas. Mais especificamente, objetivamos responder a seguinte pergunta: é possível afirmar que, na mudança do governo de Hugo Chavéz para o governo de Nicolás Maduro, houve também uma mudança de ciclo político? Argumentamos que sim, pois houve uma significativa reformulação das agendas dominantes no debate público e uma rearticulação dos atores hegemônicos nas disputas políticas, fazendo emergir inclusive novos atores. Além disso, a maneira como as instituições funcionam foi radicalmente alterada, principalmente do ponto de vista do seu funcionamento informal. O resultado disso foi que, desde 2013, está em curso um processo no qual os elementos democratizantes que marcaram o ciclo político chavista (1999-2013) vêm desaparecendo e os traços desdemocratizantes herdados desse período se acentuam progressivamente.
Myocardial Fibrosis and Cardiomyopathy Risk: A Genetic Link in the MESA
Authors: Shabani Mahsima , Wang Min , Jenkins Gregory D. , Rotter Jerome I. , Rich Stephen S. , Batzler Anthony , Taylor Kent D. , Mychaleckyj Josyf C. , Liu Duan , Lima Joao A.C. , Pereira Naveen L.
Published: August 2023

BACKGROUND:

Common genetic variants are associated with risk for hypertrophic cardiomyopathy and dilated cardiomyopathy and with left ventricular (LV) traits. Whether these variants are associated with myocardial fibrosis, an important pathophysiological mediator of cardiomyopathy, is unknown.

METHODS:

Multi-Ethnic Study of Atherosclerosis participants with T1-mapping cardiac magnetic resonance imaging in-whom extracellular volume was assessed, and genotyping information was available were included (N=1255). Log extracellular volume (%) was regressed on 50 candidate single nucleotide polymorphisms (previously identified to be associated with hypertrophic cardiomyopathy, dilated cardiomyopathy, and LV traits) adjusting for age, sex, diabetes, blood pressure, and principal components of ancestry. Ancestry-specific results were pooled by fixed-effect meta-analyses. Gene knockdown experiments were performed in human cardiac fibroblasts.

RESULTS:

The
SMARCB1
rs2186370 intronic variant (minor allele frequency: 0.18 in White and 0.50 in Black participants), previously identified as a risk variant for dilated cardiomyopathy and hypertrophic cardiomyopathy, was significantly associated with increased extracellular volume (
P=
0.0002) after adjusting for confounding clinical variables. The
SMARCB1
rs2070458 locus previously associated with increased LV wall thickness and mass was similarly significantly associated with increased extracellular volume (
P=
0.0002). The direction of effect was similar in all 4 ancestry groups, but the effect was strongest in Black participants. The variants are strong expression quantitative loci in human LV tissue and associated with genotype-dependent decreased expression of
SMARCB1
(
P=
7.3×10
-22
).
SMARCB1
knockdown in human cardiac fibroblasts resulted in increased TGF (transforming growth factor)-β1–mediated α-smooth muscle actin and collagen expression.

CONCLUSIONS:

Common genetic variation in
SMARCB1
previously associated with risk for cardiomyopathies and increased LV wall thickness is associated with increased cardiac magnetic resonance imaging–based myocardial fibrosis and increased TGF-β1 mediated myocardial fibrosis in vitro. Whether these findings suggest a pathophysiologic link between myocardial fibrosis and cardiomyopathy risk remains to be proven.
Noninvasive Assessment of Lipomatous Metaplasia as a Substrate for Ventricular Tachycardia in Chronic Infarct
Authors: Xu Lingyu , Desjardins Benoit , Witschey Walter R. , Nazarian Saman
Published: August 2023

Myocardial lipomatous metaplasia (LM) has been increasingly reported in patients with prior myocardial infarction. Cardiac magnetic resonance and cardiac contrast-enhanced computed tomography have been used to noninvasively detect and quantify myocardial LM in postinfarct patients, and may provide useful information for understanding cardiac mechanics, arrhythmia susceptibility, and prognosis. This review aims to summarize the advantages and disadvantages, clinical applications, and imaging features of different cardiac magnetic resonance sequences and cardiac contrast-enhanced computed tomography for LM detection and quantification. We also briefly summarize LM prevalence in different cohorts of postinfarct patients and review the clinical utility of cardiac imaging in exploring myocardial LM as an arrhythmogenic substrate in patients with prior myocardial infarction.
Revisiting mandibular symphyseal shape in juvenile early hominins and modern humans using a deformation-based approach
Authors: Zimmer Veronika A. , Oettlé Anna , Hoffmann Jakobus , Thackeray John Francis , Zipfel Bernhard , Braga José
Published: August 2023

The juvenile mandible is important in the investigation of ontogenetic and evolutionary changes among early hominins. We revisit the mandibular symphysis in juvenile specimens of Australopithecus africanus and Paranthropus robustus with two main contributions. First, we employ, for the first time, methods of computational anatomy to model complex symphyseal shape differences. Second, we present new fossil evidence from Kromdraai to improve our knowledge of symphyseal morphology. We describe differences between shapes by landmark-free diffeomorphism needed to align them. We assess which features of the mandibular symphysis best discriminate the juvenile symphysis in these fossil species, relative to the intraspecific variation observed among modern humans. Our approach eliminates potential methodological inconsistencies with traditional approaches (i.e., the need for homologous anatomical landmarks, assumption of linearity). By enabling detailed comparisons of complex shapes in juvenile mandibles, our proposed approach offers new perspectives for more detailed comparisons among Australopithecus, Paranthropus and early Homo.
International Legal Responses for Protecting Fishers’ Fundamental Rights Impacted by a Changing Ocean
Authors: Nakamura Julia , Cirne Lima Weston Julia , Lennan Mitchell
Published: August 2023

Climate change directly impacts the marine landscape where fishers operate. Most fishers rely on fishing for food, income and/or employment. A changing ocean can therefore significantly impact fishers’ lives and hinder the full exercise of their rights of access to fisheries resources, rights to fish, to food, to work, to culture, and to a healthy, clean and sustainable environment. This article questions whether international law supports the protection of fishers’ fundamental rights in the changing ocean context. The authors begin by elucidating what such context means to fishers and their rights, taking special account of small-scale fishers and vulnerable groups. The obligations of States Parties to key instruments under the law of the sea and international climate change law, vis-à-vis States’ obligations under human rights treaties and other relevant international guidance, are explored with a view to furthering the protection of fishers impacted by a changing ocean.
Kuduro, Digital Music and Lifestyle in Diaspora
Authors: Marcon Frank
Published: August 2023

Kuduro is a style of dance and electronic music that emerged in Angola in the nineties, in a peculiar social context. Initially consumed and produced by young people from the periphery of the city of Luanda, it became a means of expression, entertainment, socialization and subsistence, through which they became autonomous and symbolically transformed their realities of scarcity. With access to communication technologies and movements of global dispersion of people and information, kuduro also spread to other countries and gained other meanings. Here, I analyze the characteristics of its context of origin, the conditions and implications of such dispersal, and disputes over the meanings of style.
« Etes-vous la victime d’un “isme”? »: emploi nominal et référentiel du suffixe –isme
Authors: Agabalian Grigory
Published: August 2023

This article addresses the nominal use of the suffix -isme in French, as in the sentence “êtes-vous la victime d’un isme?” (“are you the victim of an ism?”). Using data from a media corpus, first I observe that there are occurrences where the suffix -isme is indeed a noun with a referential meaning (i.e. referring to extralinguistic objects), refering to doctrines, movements, religions or attitudes. Then, I observe that the suffix -isme is associated with axiologically negative realities (especially conflict) in its nominal use. From this information, I try to answer two questions: what is isme the name of and how to describe the negative assessment associated to it?
Système numéral et neutralisation du genre numéral en soureth
Authors: Skaff Rola
Published: August 2023

This article describes the numeral system in several varieties of Soureth, one of the modern languages derived from the eastern branch of Aramaic, a Semitic language of the Northwest.

Historically, it has been spoken in Iraq, Syria, Iran, and southeastern Turkey; and in the diaspora since the early 20th century.

After describing the system in general, the article will study a particular phenomenon concerning the gender agreement between the numeral and the counted name. Modern Aramaic, like the classical language, Syriac, has a binary gender marking on the noun (masculine or feminine), which affects the relations of agreement. The numeral system also contains marked masculine and feminine forms that agree with the noun (Coghill 2004 & 2018, Poizat 2008). However, there is a process of gender neutralization of the numeral that occurs (Khan 2009). Indeed, numerals do not always change according to the gender of the name counted. They thus have a single form that could be called a “neutral” form.

This paper presents the different uses of numerals in an oral corpus made up with Soureth speakers living in France. Some hypotheses will be proposed in order to analyze the neutralization process which does not exist in an absolute way in all varieties.
Regard sur quelques facteurs de sélection des subordonnants relatifs du français par des apprenants norvégiens
Authors: Stenkløv Nelly Foucher , Helland Hans Petter , Larrivée Pierre
Published: August 2023

Acquisition of relative is subject to the Accessibility Hierarchy developed by Keenan and Comrie (1977), and should not be subject to mother tongue transfer effects, even if these are documented. The tension between transfer and hierarchy is therefore explored on the basis of the acquisition of French relatives by Norwegian learners. These are interesting because Norwegian has a different relative system from French, and Norwegian speakers are generally multilingual, multiplying the sources of transfer. The guided and free productions of beginner and intermediate Norwegian learners make it possible to establish not only the error rate, but also the position of the erroneous relative on the accessibility hierarchy. However, the relatives used incorrectly are not necessarily more accessible in the hierarchy than the relative which should be used. There are nonetheless potential interfering effects from the animacy value of the antecedent.
Mechanical performances of polyvinyl chloride (PVC) foam sandwich composites with glass cloth face-sheet
Authors: Zhao Jitao , Yan Yutong , Xu Lidan , Zhang Hongxia
Published: August 2023

The mechanical performances of polyvinyl chloride (PVC) foam sandwich panels with different types of cores prepared by vacuum-assisted resin infusion process (VARI) were investigated. The flatwise, edge-wise compression, flexural and impact properties of three types of PVC sandwich panels of the prepared panels were performed. The results show that the mechanical performances of the foam sandwich composites can be enhanced due to the presence of polymer pins, and the impact properties appear slightly different at different stages. Due to the existence of pins, the energy absorption and impact properties of the sandwich panels are slightly reduced during the impact rebound phase, while the impact properties of the three sandwich panels do not change much during the impact penetrated phase. The contact surface and the cross-section through the damaged area were observed to analyze the failure modes of sandwich composites.
MnO2 nanodrug mediates the expression of antigen-presenting cell through combined chemotherapy to enhance the antineoplastic curative function
Authors: Li Xu , Ma Yuhui
Published: August 2023

Nano-conjugated compounds are studied in tumor treatment. However, little is known on the function of MnO2 nanodrug mediated by combined chemotherapy. This study explored the efficacy of MnO2 nanodrug applied in combined chemotherapy and evaluated its antineoplastic
efficacy in vivo. Confocal microscope was used to detect the transfection efficiency in tumor cells. Nanoparticles with MnO2 as core (MnO2 NPs) were prepared. The antineoplastic activity efficiency of MnO2 NPs loaded with doxorubicin (DOX) was tested
by cell viability test and cell biological behaviors. And the proliferation activity of the co-loading complex on tumor cells was tested in mice in vivo. RT-PCR and flow cytometry detected the expression of adenomatous polyposis coli (APC) mediated by MnO2 nanodrug combined
chemotherapy. Co-loading MnO2 NPs and DOX showed a high activity on cells. The mobility of MnO2 NPs DOX cells was weakened and co-loading could inhibit cell invasion. The in vivo studies showed that the metastasis of tumor cells was inhibited after the mice received
co-loading. Compared with DOX group, ki67 and APC in co-loading group decreased significantly and the expression of IFN-γ mediated by co-loading drugs was higher than control group, indicating that APC is involved in inhibiting tumor cell growth and metastasis by co-loading. MnO2
nanodrug can enhance the antineoplastic function through APC mediated by combined chemotherapy and inhibit the tumor growth by enhancing the synergistic function of inhibiting the growth, migration, and invasion of tumor cells.
Effect of ice treatment combined with nano-silver hydrogel nursing in operative area after microwave ablation of benign thyroid nodule
Authors: Shi Jing , Wang Xuguang
Published: August 2023

This study aims to evaluate the effect of microwave ablation (MWA) and the effect of ice nursing combined with nano-silver hydrogel nursing on postoperative recovery. The clinical data of 120 patients with benign thyroid nodules who received MWA from January 2019 to December 2021 were
retrospectively analyzed. The patients were randomly divided into the control (60 cases) and observation (60 cases) groups. The control group received routine nursing, and the observation group received postoperative ice nursing and nano-silver hydrogel nursing on the basis of routine nursing.
Postoperative skin temperature, SF-MPQ pain scale scores, state anxiety inventory (S-AI) scores, general comfort questionnaire scores for each dimension, and incidence of postoperative adverse reactions were compared between the two groups. At admission, differences in basic data between the
two groups were statistically insignificant (P >0.05). After ice nursing and nano-silver hydrogel nursing was complete, skin temperature of the participants decreased with the extension of cold treatment time; moreover, compared to the control group, the observation group had lower
skin temperature and a lower incidence of hematoma after nursing (P <0.05). Postoperative SF-MPQ pain scores of patients decreased gradually; SF-MPQ pain scores and corresponding S-AI scores of patients in the observation group were lower than those in the control group. Compared
to that before nursing, the comfort level of patients after postoperative care significantly improved. Compared to that in the control group, the comfort score of physiological and psychological dimensions in the General Comfort Questionnaire score of the observation group was higher after
nursing, and the overall comfort score of the observation group was higher (P <0.05). There was no significant difference in the incidence of postoperative adverse reactions between the two groups. Nursing satisfaction was higher in the observation group than the control group. The
use of MWA in the treatment of benign thyroid nodule has a good effect and the incidence of postoperative adverse reactions is low. Postoperative ice nursing can reduce skin temperature in the operative area, relieve pain, and reduce psychological and physiological pressure of patients, as
well as improve nursing satisfaction. Thus, postoperative ice nursing and nano-silver hydrogel nursing has great potential in promoting postoperative recovery after MWA.
Research on mechanism of novel isoflavone F11 in protecting rotator cuff injury through vascular endothelial growth factor signal pathway
Authors: Wang Wei , Zhang Bo , Ge Hao , Tang Tongjun , Xue Ning
Published: August 2023

This study discusses the mechanism of novel isoflavone F11 in protecting rotator cuff injury through vascular endothelial growth factor (VEGF) signal pathway. 60 rats were assigned into sham group, RCT group, low F11 group, middle F11 group, high F11 group, and huqian pill group. The
level of IL-1β, IL-6 and tumor necrosis factor alpha (TNF-α) was detected with enzyme-linked immunosorbent assay (ELISA) method. The max load was detected with MTS biomechanics experiment. The pathological form of tissue was detected with HE staining method. The expression
of VEGF and basic fibroblast growth factor (BFGF) was detected with western blot and real-time reverse transcription–polymerase chain reaction (RT-PCR). The level of IL-1β, IL-6 and TNF-α in RCT group was higher than that in sham group. The max load was reduced.
Their level in low F11 group, middle F11 group, high F11 group and huqian pill group was lower than RCT group with a significant difference in max load. VEGF and BFGF expression in RCT group was lower than sham group. It was increasing along with the increasing concentration of adopted F11.
The level of inflammation in serum was reduced with F11. The biomechanics of bone could be increased. Thus, it could develop protecting action on rotator cuff injury through activating the level of VEGF.
Astragaloside IV ameliorates cerebral ischemic damage by restraining adenosine monophosphate-activated protein kinase/mTOR-triggered autophagic process and apoptotic activity in neurons
Authors: Hao Huan , Yang Jianjun , Zhu Jianguang
Published: August 2023

Astragaloside IV is a natural saponin purified from Astragalus membranaceus that exerts a promising effect on Alzheimer’s disease (AD). This study explored its effects on cerebral ischemic injury. SD rats were randomized into sham-operation group, Vehicle (MCAO) group and Astragaloside
IV groups (25, 50 and 100 mg/kg, respectively), followed by analysis of neurological deficit, brain edema, infarct volume and neuronal apoptosis. In addition, autophagy was also monitored using an electron microscope. Finally, the functional mechanism for Astragaloside IV was studied via Western-blotting.
Astragaloside IV can ameliorate brain ischemia/reperfusion injury and consequent neurological malfunction. The induction of autophagy is a participant in the protective mechanism for SH-SY5Y cells against brain ischemia/reperfusion damage. Additionally, Astragaloside IV can trigger autophagy
by manipulating AMPK/mTOR signal pathway. For SH-SY5Y cells, Astragaloside IV ameliorates oxygen-glucose deprivation-reoxygenation damage via restraining of AMPK/mTOR-triggered autophagic process and mitochondria-mediated apoptotic activity. In conclusion, Astragaloside IV can execute a neuroprotective
effect on cerebral ischemia, implying that it might be a promising candidate drug in the therapy and prophylaxis of ischemic stroke.
Matrine inhibits miR-181a-mediated chemoresistance in rectal cancer
Authors: Gu Wenzhe , Shen Zhengjie
Published: August 2023

Chemotherapy is widely used for treating rectal cancer, but the existence of drug resistance during chemotherapy hinders the therapeutic effect of chemotherapy. Studies have found that matrine inhibits miR-181a and PI3K-Akt and the expression of miR-181a affects PI3K-Akt activity. Therefore,
this paper explores whether matrine can affect PI3K-Akt activity by regulating miR-181a via constructing a rat model of rectal cancer, and finally reduce the chemotherapy resistance of rectal cancer. The rat model of rectal cancer was constructed, treated with the chemotherapy drug pentafluorouracil
(5-FU), and assigned into model group, chemotherapy-resistant group, low-dose and high-dose matrine group followed by analysis of the pathology by HE staining. Rectal cancer tissues were used to construct miR-181a silencing group and miR-181a overexpression group followed by measuring cell
inhibition by MTT assay, cell proliferation and apoptosis by flow cytometry, and the levels of miR-181a, PI3K and Akt. (1) miR-181a expression was related to matrine’s inhibition of chemotherapy resistance in rectal cancer; (2) miR-181a expression induced PI3K-Akt signaling during matrine’s
inhibition of chemotherapy resistance; (3) matrine can further inhibit PI3K-Akt activation by inhibiting miR-181a to enhance the sensitivity of chemotherapy resistance. Matrine can inhibit the expression of miR-181a to reduce PI3K-AKT signaling activity and decrease chemotherapy resistance
of rectal cancer. It provides a new idea for clinical chemotherapy drugs to treat rectal cancer and increases the therapeutic effects.
Preparation method and process of gadolinium gallium aluminum garnet-based ceramic nanopowders
Authors: Zan Yongxi , Hu Tao , Jiang Zhouqing , Chen Guantong , Liu Yuanhong , Liu Ronghui
Published: August 2023

Gadolinium gallium aluminum garnet has a unique cubic structure, and high optical yield, high density and fast decay rate, it is because of the above advantages has become one of the most promising scintillation materials, is widely used in a variety of industries. The main methods
of oxide transparent ceramic powder preparation are solid-phase reaction synthesis, alcohol salt hydrolysis, sol–gel method, chemical co-precipitation method, etc. Solid-phase reaction synthesis requires high reaction temperature and long reaction time, and it is difficult to achieve
homogeneous chemical composition by ball-mill mixing, therefore, it is difficult to prepare homogeneous and high sintering activity powder by solid-phase reaction. Alcohol salt hydrolysis method can prepare high purity powder, but it is generally rarely used because the raw materials are expensive
and difficult to obtain. Co-precipitation method can achieve the molecular level of mixing, the preparation of powder process is simple, while the calcination temperature of powder synthesis can be reduced to prepare excellent performance of the powder. Therefore, in order to obtain nanopowders
with uniform particle size, good dispersion, regular and nearly spherical shape, and suitable for the preparation of transparent ceramics. In this paper, we studied the preparation method and process of gadolinium gallium aluminum garnet ceramic nanopowders, and further analyzed the influencing
factors of synthesizing gadolinium gallium aluminum garnet ceramic nanopowders, in order to provide some reference for the related research of gadolinium gallium aluminum garnet ceramic nanopowders.
Evaluation of visual perceptual training-assisted far-infrared nanomaterial-based eye relaxation system combined with chinese medicine therapy to control myopia in adolescents
Authors: Liu Fei , Zhao Bo , Tian Mi
Published: August 2023

This study investigated the efficacy of the far-infrared eye relaxation system assisted visual perceptual training (VPT) combined with auricular point sticking (APS) in myopia. Fifty-two adolescent myopic patients were randomly divided into the comprehensive intervention and control
groups. The control group received optometry therapy, whereas the comprehensive treatment group received VPT combined with APS and supplemented with an eye relaxation system. The zinc oxide and silica nanoparticles used in the eye relaxation system could maintain good stability in acid and
alkali, and had a considerable bactericidal effect. After treatment, patients in the comprehensive intervention group showed significant improvements in ocular accommodation, visual acuity, and diopter. Furthermore, the growth rate of the axial length and intraocular pressure were significantly
controlled, while lens thickness decreased and eye fatigue improved. Thus, the combination of VPT and APS shows great potential in the myopia therapy.
Quantitative identification of triassic top unconformity: vertical structure and its reservoir significance in the sanbian area of the ordos basin
Authors: Sun Tongwen , Liu Guanglin , Yan Baiquan , Hu Ming , Zhang Zhongyi , Hui Xiao , Gong Lei , Wang Wei
Published: August 2023

The Triassic top unconformity in the Ordos Basin, which serves as a transfer station for hydrocarbon migration, has become a bottleneck for Mesozoic oil and gas exploration. Taking the Sanbian area as an example, based on core observations, petrophysical properties, and a weathering index analysis of five coring wells, a standard for the quantitative identification of the vertical structure of the unconformity is established using the optimal segmentation method and principal component analysis of conventional logging curves. The standard is then applied to 40 real wells, and 32 typical unconformity reservoirs are dissected. The results show that the reclassification of the unconformity surface corrects the 17.5% error in the geological stratification as an unconformity. On this basis, a quantitative identification standard for the structure of the unconformity is established via the principal component curve. The analysis of unconformity structure types applied to five paleogeomorphic units reveals that the slope mouth and slope develop three layers of structure, namely residual layer, weathered clay layer, and weathered leaching zone, while highlands, river valleys, and inter-river hills lack weathered clay layer. As an independent oil and gas-bearing layer, the unconformity has two types of reservoir-forming models. The first is the hydrocarbon accumulation in the Chang1–Chang2 member shielded by weathered clay layer in the slope mouth and slope. The second is hydrocarbon migrated from the residual layer to the local structural high part of the Yan 10–Yan 9 member in the slope mouth. The hydrocarbon in the unconformity is complementary to the upper Yan 10–Yan 9 member and the lower unweathered rock layer of Yanchang Formation. The results of this study are of great significance to the quantitative identification of unconformity structures in exploration wells without coring data in the study area, as well as to future hydrocarbon exploration in the Mesozoic strata.