bluuebunny/crossref_metadata_2025 huggingface dataset:
Fish feeds supplemented with calcium-based buffering minerals decrease stomach acidity, increase the blood alkaline tide and cost more to digest
Authors: Goodrich Harriet R. , Berry Alex A. , Montgomery Daniel W. , Davison William G. , Wilson Rod W.
Published: November 2022

Predatory fish in the wild consume whole prey including hard skeletal parts like shell and bone. Shell and bone are made up of the buffering minerals calcium carbonate (CaCO3) and calcium phosphate (Ca3(PO4)2). These minerals resist changes in pH, meaning they could have physiological consequences for gastric acidity, digestion and metabolism in fish. Using isocaloric diets supplemented with either CaCO3, Ca3(PO4)2 or CaCl2 as non-buffering control, we investigated the impacts of dietary buffering on the energetic cost of digestion (i.e. specific dynamic action or SDA), gastric pH, the postprandial blood alkalosis (the “alkaline tide”) and growth in juvenile rainbow trout (Oncorhynchus mykiss). Increases in dietary buffering were significantly associated with increased stomach chyme pH, postprandial blood HCO3−, net base excretion, the total SDA and peak SDA but did not influence growth efficiency in a 21 day trial. This result shows that aspects of a meal that have no nutritional value can influence the physiological and energetic costs associated with digestion in fish, but that a reduction in the SDA will not always lead to improvements in growth efficiency. We discuss the broader implications of these findings for the gastrointestinal physiology of fishes, trade-offs in prey choice in the wild, anthropogenic warming and feed formulation in aquaculture.
Insights into the quality of recombinant proteins produced by two different Bombyx mori expression systems
Authors: Kajiura Hiroyuki , Tatematsu Ken-ichiro , Nomura Tsuyoshi , Miyazawa Mitsuhiro , Usami Akihiro , Tamura Toshiki , Sezutsu Hideki , Fujiyama Kazuhito
Published: November 2022

The silkworm,Bombyx mori, is an attractive host for recombinant protein production due to its high expression efficiency, quality, and quantity. Two expression systems have been widely used for recombinant protein production inB. mori: baculovirus/silkworm expression system and transgenic silkworm expression system. Both expression systems enable high protein production, but the qualities of the resulting recombinant proteins have not been well evaluated. In this study, we expressed bovine interferon γ (IFN-γ) using the two systems and examined the quality of the resulting proteins in terms ofN-glycosylation and protein cleavage. Both expression systems successfully produced IFN-γ as anN-glycoprotein. Although the production in the baculovirus/silkworm expression system was much more efficient than that in the transgenic silkworm expression system, unexpected variants of IFN-γ were also produced in the former system due to the differentN-glycosylation and C-terminal truncations. These results indicate that while high protein production could be achieved in the baculovirus/silkworm expression system, unintentional protein modification might occur, and therefore protein expression in the transgenic silkworm expression system is preferable from the point-of-view ofN-glycosylation of the recombinant protein and evasion of unexpected attack by a protease inB. mori.
Weber number and the outcome of binary collisions between quantum droplets
Authors: Alba-Arroyo J. E. , Caballero-Benitez S. F. , Jáuregui R.
Published: November 2022

A theoretical analysis of binary collisions of quantum droplets under feasible experimental conditions is reported. Droplets formed from degenerate dilute Bose gases made up from binary mixtures of ultracold atoms are considered. Reliable expressions for the surface tension of the droplets are introduced based on a study of low energy excitations of their ground state within the random phase approximation. Their relevance is evaluated considering an estimation of the expected excitation energy having in mind the Thouless variational theorem. The surface tension expressions allow calculating the Weber number of the droplets involved in the collisions. Several regimes on the outcomes of the binary frontal collisions that range from the coalescence of the quantum droplets to their disintegration into smaller droplets are identified. Atoms losses of the droplets derived from self-evaporation and three-body scattering are quantified for both homo- and hetero-nuclear mixtures. Their control is mandatory for the observation of some interesting effects arising from droplets collisions.
Strategies of protected area use by Asian elephants in relation to motivational state and social affiliations
Authors: Madsen Anastasia E. , Minge Christin , Pushpakumara T. V. , Weerathunga U. Sameera , Padmalal U. K. , Weerakoon Devaka K. , de Silva Shermin
Published: November 2022

Animals’ space requirements may vary according to life-history and social considerations. We observed 516 wild adult Asian elephants from both sexes, over 9 years, to investigate how life-history traits and social behavior influence protected-area (PA) use at Udawalawe National Park, Sri Lanka. Male PA-use, quantified in terms of average between-sightings-interval (BSI), was significantly influenced by the interaction of age class and motivational state (i.e. reproduction vs. foraging). Musth lengthened with age, with a median of 24.5 days for ages 21–30, 32.5 days for ages 31–40, and 45 days for those > 40. A minority (11%) used it exclusively during musth, while others used it exclusively for foraging (44%) or both (45%). Males using it in both states and older musth-only males were more likely to be seen across years. There were 16 social communities containing between 2–22 adult females. Females’ BSI was significantly influenced by social ties, but this relationship was weak, because members of social communities do not necessarily disperse together, resulting in high individual variation in space-use. Inter-annual variability in sightings among individuals of both sexes indicates that around ¾ of the population is likely non-residential across years, challenging the prevailing fortress-conservation paradigm of wildlife management.
Data-driven comorbidity analysis of 100 common disorders reveals patient subgroups with differing mortality risks and laboratory correlates
Authors: Koskinen Miika , Salmi Jani K. , Loukola Anu , Mäkelä Mika J. , Sinisalo Juha , Carpén Olli , Renkonen Risto
Published: November 2022

The populational heterogeneity of a disease, in part due to comorbidity, poses several complexities. Individual comorbidity profiles, on the other hand, contain useful information to refine phenotyping, prognostication, and risk assessment, and they provide clues to underlying biology. Nevertheless, the spectrum and the implications of the diagnosis profiles remain largely uncharted. Here we mapped comorbidity patterns in 100 common diseases using 4-year retrospective data from 526,779 patients and developed an online tool to visualize the results. Our analysis exposed disease-specific patient subgroups with distinctive diagnosis patterns, survival functions, and laboratory correlates. Computational modeling and real-world data shed light on the structure, variation, and relevance of populational comorbidity patterns, paving the way for improved diagnostics, risk assessment, and individualization of care. Variation in outcomes and biological correlates of a disease emphasizes the importance of evaluating the generalizability of current treatment strategies, as well as considering the limitations that selective inclusion criteria pose on clinical trials.
Extreme temperature increases the risk of stillbirth in the third trimester of pregnancy
Authors: Yang Hsiao-Yu , Lee Jason Kai Wei , Chio Chia-Pin
Published: November 2022

Epidemiological studies have reported the association between extreme temperatures and adverse reproductive effects. However, the susceptible period of exposure during pregnancy remains unclear. This study aimed to assess the impact of extreme temperature on the stillbirth rate. We performed a time-series analysis to explore the associations between temperature and stillbirth with a distributed lag nonlinear model. A total of 22,769 stillbirths in Taiwan between 2009 and 2018 were enrolled. The mean stillbirth rate was 11.3 ± 1.4 per 1000 births. The relative risk of stillbirth due to exposure to extreme heat temperature (> 29 °C) was 1.18 (95% CI 1.11, 1.25). Pregnant women in the third trimester were most susceptible to the effects of extreme cold and heat temperatures. At lag of 0–3 months, the cumulative relative risk (CRR) of stillbirth for exposure to extreme heat temperature (29.8 °C, 97.5th percentile of temperature) relative to the optimal temperature (21 °C) was 2.49 (95% CI: 1.24, 5.03), and the CRR of stillbirth for exposure to extreme low temperature (16.5 °C, 1st percentile) was 1.29 (95% CI: 0.93, 1.80). The stillbirth rate in Taiwan is on the rise. Our findings inform public health interventions to manage the health impacts of climate change.
Scene-relative object motion biases depth percepts
Authors: French Ranran L. , DeAngelis Gregory C.
Published: November 2022

An important function of the visual system is to represent 3D scene structure from a sequence of 2D images projected onto the retinae. During observer translation, the relative image motion of stationary objects at different distances (motion parallax) provides potent depth information. However, if an object moves relative to the scene, this complicates the computation of depth from motion parallax since there will be an additional component of image motion related to scene-relative object motion. To correctly compute depth from motion parallax, only the component of image motion caused by self-motion should be used by the brain. Previous experimental and theoretical work on perception of depth from motion parallax has assumed that objects are stationary in the world. Thus, it is unknown whether perceived depth based on motion parallax is biased by object motion relative to the scene. Naïve human subjects viewed a virtual 3D scene consisting of a ground plane and stationary background objects, while lateral self-motion was simulated by optic flow. A target object could be either stationary or moving laterally at different velocities, and subjects were asked to judge the depth of the object relative to the plane of fixation. Subjects showed a far bias when object and observer moved in the same direction, and a near bias when object and observer moved in opposite directions. This pattern of biases is expected if subjects confound image motion due to self-motion with that due to scene-relative object motion. These biases were large when the object was viewed monocularly, and were greatly reduced, but not eliminated, when binocular disparity cues were provided. Our findings establish that scene-relative object motion can confound perceptual judgements of depth during self-motion.
Nucleation of cadherin clusters on cell-cell interfaces
Authors: Ibata Neil , Terentjev Eugene M.
Published: November 2022

Cadherins mediate cell-cell adhesion and help the cell determine its shape and function. Here we study collective cadherin organization and interactions within cell-cell contact areas, and find the cadherin density at which a ‘gas-liquid’ phase transition occurs, when cadherin monomers begin to aggregate into dense clusters. We use a 2D lattice model of a cell-cell contact area, and coarse-grain to the continuous number density of cadherin to map the model onto the Cahn-Hilliard coarsening theory. This predicts the density required for nucleation, the characteristic length scale of the process, and the number density of clusters. The analytical predictions of the model are in good agreement with experimental observations of cadherin clustering in epithelial tissues.
Parallel functional annotation of cancer-associated missense mutations in histone methyltransferases
Authors: Canning Ashley J. , Viggiano Susan , Fernandez-Zapico Martin E. , Cosgrove Michael S.
Published: November 2022

Using exome sequencing for biomarker discovery and precision medicine requires connecting nucleotide-level variation with functional changes in encoded proteins. However, for functionally annotating the thousands of cancer-associated missense mutations, or variants of uncertain significance (VUS), purifying variant proteins for biochemical and functional analysis is cost-prohibitive and inefficient. We describe parallel functional annotation (PFA) of large numbers of VUS using small cultures and crude extracts in 96-well plates. Using members of a histone methyltransferase family, we demonstrate high-throughput structural and functional annotation of cancer-associated mutations. By combining functional annotation of paralogs, we discovered two phylogenetic and clustering parameters that improve the accuracy of sequence-based functional predictions to over 90%. Our results demonstrate the value of PFA for defining oncogenic/tumor suppressor functions of histone methyltransferases as well as enhancing the accuracy of sequence-based algorithms in predicting the effects of cancer-associated mutations.
Aerosol jet printing polymer dispersed liquid crystals on highly curved optical surfaces and edges
Authors: Davies Matthew , Hobbs Matthew J. , Nohl James , Davies Benedict , Rodenburg Cornelia , Willmott Jon R.
Published: November 2022

We demonstrate a new technique for producing Polymer Dispersed Liquid Crystal (PDLC) devices utilising aerosol jet printing (AJP). PDLCs require two substrates to act as scaffold for the Indium Tin Oxide electrodes, which restricts the device geometries. Our approach precludes the requirement for the second substrate by printing the electrode directly onto the surface of the PDLC, which is also printed. The process has the potential to be precursory to the implementation of non-contact printing techniques for a variety of liquid crystal-based devices on non-planar substrates. We report the demonstration of direct deposition of PDLC films onto non-planar optical surfaces, including a functional device printed over the 90° edge of a prism. Scanning Electron Microscopy is used to inspect surface features of the polymer electrodes and the liquid crystal domains in the host polymer. The minimum relaxation time of the PDLC was measured at 1.3 ms with an 800 Hz, 90 V, peak-to-peak (Vpp) applied AC field. Cross-polarised transmission is reduced by up to a factor of 3.9. A transparent/scattering contrast ratio of 1.4 is reported between 0 and 140 V at 100 Hz.
Characteristics and outcomes of severe COVID-19 in hospitalized patients with cardiovascular diseases in the Amazonian region of Brazil: a retrospective cohort
Authors: Sardinha Daniele Melo , de Sá Carmem Aliandra Freire , Rodrigues Yan Corrêa , dos Santos Freitas Joyce , Brodeur Ketan , do Socorro Pompeu de Loiola Rosane , Lima Karla Valéria Batista , de Paula Souza e Guimarães Ricardo José , Lima Luana Nepomuceno Gondim Costa
Published: November 2022

The northern region of Brazil is already vulnerable to other infectious diseases and it was no different in COVID-19. However, cardiovascular diseases still lead the causes of death. Thus, the objective of this study is to identify the clinical predictors and outcome of severe COVID-19 in hospitalized patients with and without CVD in this region of the Amazon. A retrospective cohort, referring to the notifications from January 1 to December 31, 2020, including cases confirmed by molecular testing. The study consisted of 9223 confirmed cases for COVID-19. Of these, 6011 (65.17%) did not have cardiovascular disease and 3212 (34.83%) had some cardiovascular disease. The significance of deaths was in the age group of < 1 to 59 CVD carriers (< 0.001). Predictor of mortality were invasive ventilation for patients with CVD, (OR 23,688 CI 18,180–30,866), followed by chronic kidney disease (OR 2442 CI 1568–3740), dyspnea (OR 2312 CI 1817–3941), respiratory distress (OR 1523 CI 1210–2919), cough (OR 1268 CI 1005–1599), Lower oxygen saturation 95% (OR 1281 CI 1039–1579), diabetes mellitus (OR 1267 CI 1050–1528) and age (OR 1051 CI 1044–1058). Carriers of CVD had a lower survival rate (< 0.0001). The order of the predictors of death differed among the non-carriers, as well as the high odds ratio in the predictors of CVD, only cough was an independent predictor. The age group under 59 years was associated with deaths. We also show the shorter survival in CVD carriers, as well as the higher cardiovascular morbidity rate than other studies in the literature.
Estimation of hospital visits for respiratory diseases attributable to PM10 from vegetation fire smoke and health impacts of regulatory intervention in Upper Northern Thailand
Authors: Uttajug Athicha , Ueda Kayo , Honda Akiko , Takano Hirohisa
Published: November 2022

The air quality in Upper Northern Thailand (UNT) deteriorates during seasonal vegetation fire events, causing adverse effects especially on respiratory health outcomes. This study aimed to quantitatively estimate respiratory morbidity from vegetation fire smoke exposure, and to assess the impact of a burning ban enforced in 2016 on morbidity burden in UNT. We computed daily population exposure to fire-originated PM10 and estimated its health burden during a 5-year period from 2014 to 2018 using daily fire-originated PM10 concentration and the concentration–response function for short-term exposure to PM10 from vegetation fire smoke and respiratory morbidity. In subgroups classified as children and older adults, the health burden of respiratory morbidity was estimated using specific effect coefficients from previous studies conducted in UNT. Finally, we compared the health burden of respiratory morbidity before and after burning ban enforcement. Approximately 130,000 hospital visits for respiratory diseases were estimated to be attributable to fire-originated PM10 in UNT from 2014 to 2018. This estimation accounted for 1.3% of total hospital visits for respiratory diseases during the 5-year period, and 20% of those during burning events. Age-specific estimates revealed a larger impact of PM10 in the older adult group. The number of hospital visits for respiratory diseases attributable to fire-originated PM10 decreased from 1.8% to 0.5% after the burning ban policy was implemented in the area. Our findings suggest that PM10 released from vegetation fires is a health burden in UNT. The prohibition of the burning using regulatory measure had a positive impact on respiratory morbidity in this area.
Degradation and fragmentation behavior of polypropylene and polystyrene in water
Authors: Nakatani Hisayuki , Ohshima Yuina , Uchiyama Taishi , Motokucho Suguru
Published: November 2022

The polystyrene (PS) retrieved from the beach exhibited no change in surface texture. In contrast to it, the retrieved polypropylene (PP) had a rumpled surface texture. Highly reactive sulfate radical generated by K2S2O8 was employed as degradation initiator of PP and PS, and their degradation behavior was studied in water. The PS carbonyl index value gradually went up down, and its molecular weight (MW) curve discontinuously shifted to a lower MW with the increase of the degradation time unlike the PP. It was found that the PP microplastic production rate was approximately three time higher than the PS from weight ratio dependence on degradation time. The higher microplastic production rate of PP arose from its crystallizability. The voids were produced by change in specific volume occurring by chemi-crystallization and then provoked the cracks leading to quick fragmentation. The SEM photographs suggested that the PP microplastic size facilely reached nm order by the cracking around lamella.
Geostationary satellite reveals increasing marine isoprene emissions in the center of the equatorial Pacific Ocean
Authors: Zhang Wentai , Gu Dasa
Published: November 2022

Isoprene is the most abundant non-methane biogenic volatile organic compound in the Earth’s atmosphere and has the potential to influence photochemistry in the remote ocean–atmosphere. Marine isoprene emission estimates vary over multiple orders of magnitude using different methods, and the paucity of continuous in-situ measurements makes it challenging to distinguish their spatiotemporal variations. Here we present marine isoprene emission estimates inferred from Himawari-8 observations and model simulation covering the western Pacific Ocean and the eastern Indian Ocean. Although most isoprene emission hotspots were near coasts, we found an unexpected emission pool in the center of the equatorial Pacific Ocean with 18% higher emissions than those in the North and South Pacific Oceans. Remarkably, the isoprene emissions increased by 5.5 ± 0.1% per year in the center of the equatorial Pacific Ocean between August 2015 and December 2020, while no significant trend for emissions in other ocean regions. We investigated marine isoprene oxidation impacts based on satellite observations, and the results suggest NO2 may play a critical role during aerosol formation from isoprene in the remote ocean air.
Cytidine analogs are synthetic lethal with base excision repair default due to MBD4 deficiency
Authors: Chabot Thomas , Nemati Fariba , Herbette Aurélie , Demeyer Alexandre , Dayot Stéphane , Ganier Olivier , Alsafadi Samar , Gardrat Sophie , Mariani Pascale , Luporsi Marie , Corbé Maxime , Servois Vincent , Cassoux Nathalie , Decaudin Didier , Roman Sergio Roman , Del Nery Elaine , Piperno-Neumann Sophie , Stern Marc-Henri , Rodrigues Manuel
Published: November 2022

Inactivating mutations of MBD4 have been reported in subsets of various tumors. A deficiency of this DNA glycosylase, recognizing specifically T:G mismatch resulting from the deamination of methyl-cytosine, results in a hypermutated phenotype due to the accumulation of CpG>TpG transitions. Here, we hypothesize that the difference in DNA metabolism consecutive to MBD4 deficiency may result in specific cytotoxicities in MBD4-deficient tumor cells in a synthetic lethality fashion. After a large-scale drug repurposing screen, we show in two isogenic MBD4 knock-out cell models that the inactivation of MBD4 sensitizes cancer cells to cytidine analogs. We further confirm the exquisite activity of gemcitabine in an MBD4-deficient co-clinical model as (i) it completely prevented the development of an MBD4-deficient uveal melanoma patient-derived xenograft and (ii) treatment in the corresponding patient resulted in an exceptional tumor response. These data suggest that patients harboring MBD4-deficient tumors may be treated efficiently by cytidine analogs.
Discovering a trans-omics biomarker signature that predisposes high risk diabetic patients to diabetic kidney disease
Authors: Wu I-Wen , Tsai Tsung-Hsien , Lo Chi-Jen , Chou Yi-Ju , Yeh Chi-Hsiao , Chan Yun-Hsuan , Chen Jun-Hong , Hsu Paul Wei-Che , Pan Heng-Chih , Hsu Heng-Jung , Chen Chun-Yu , Lee Chin-Chan , Shyu Yu-Chiau , Lin Chih-Lang , Cheng Mei-Ling , Lai Chi-Chun , Sytwu Huey-Kang , Tsai Ting-Fen
Published: November 2022

Diabetic kidney disease is the leading cause of end-stage kidney disease worldwide; however, the integration of high-dimensional trans-omics data to predict this diabetic complication is rare. We develop artificial intelligence (AI)-assisted models using machine learning algorithms to identify a biomarker signature that predisposes high risk patients with diabetes mellitus (DM) to diabetic kidney disease based on clinical information, untargeted metabolomics, targeted lipidomics and genome-wide single nucleotide polymorphism (SNP) datasets. This involves 618 individuals who are split into training and testing cohorts of 557 and 61 subjects, respectively. Three models are developed. In model 1, the top 20 features selected by AI give an accuracy rate of 0.83 and an area under curve (AUC) of 0.89 when differentiating DM and non-DM individuals. In model 2, among DM patients, a biomarker signature of 10 AI-selected features gives an accuracy rate of 0.70 and an AUC of 0.76 when identifying subjects at high risk of renal impairment. In model 3, among non-DM patients, a biomarker signature of 25 AI-selected features gives an accuracy rate of 0.82 and an AUC of 0.76 when pinpointing subjects at high risk of chronic kidney disease. In addition, the performance of the three models is rigorously verified using an independent validation cohort. Intriguingly, analysis of the protein–protein interaction network of the genes containing the identified SNPs (RPTOR, CLPTM1L, ALDH1L1, LY6D, PCDH9, B3GNTL1, CDS1, ADCYAP and FAM53A) reveals that, at the molecular level, there seems to be interconnected factors that have an effect on the progression of renal impairment among DM patients. In conclusion, our findings reveal the potential of employing machine learning algorithms to augment traditional methods and our findings suggest what molecular mechanisms may underlie the complex interaction between DM and chronic kidney disease. Moreover, the development of our AI-assisted models will improve precision when diagnosing renal impairment in predisposed patients, both DM and non-DM. Finally, a large prospective cohort study is needed to validate the clinical utility and mechanistic implications of these biomarker signatures.
Wireless neuromodulation in vitro and in vivo by intrinsic TRPC-mediated magnetomechanical stimulation
Authors: Su Chih-Lun , Cheng Chao-Chun , Yen Ping-Hsiang , Huang Jun-Xuan , Ting Yen-Jing , Chiang Po-Han
Published: November 2022

Various magnetic deep brain stimulation (DBS) methods have been developing rapidly in the last decade for minimizing the invasiveness of DBS. However, current magnetic DBS methods, such as magnetothermal and magnetomechanical stimulation, require overexpressing exogeneous ion channels in the central nervous system (CNS). It is unclear whether magnetomechanical stimulation can modulate non-transgenic CNS neurons or not. Here, we reveal that the torque of magnetic nanodiscs with weak and slow alternative magnetic field (50 mT at 10 Hz) could activate neurons through the intrinsic transient receptor potential canonical channels (TRPC), which are mechanosensitive ion channels widely expressed in the brain. The immunostaining with c-fos shows the increasement of neuronal activity by wireless DBS with magnetomechanical approach in vivo. Overall, this research demonstrates a magnetic nanodiscs-based magnetomechanical approach that can be used for wireless neuronal stimulation in vitro and untethered DBS in vivo without implants or genetic manipulation.
Design and integration of single-qubit rotations and two-qubit gates in silicon above one Kelvin
Authors: Petit Luca , Russ Maximilian , Eenink Gertjan H. G. J. , Lawrie William I. L. , Clarke James S. , Vandersypen Lieven M. K. , Veldhorst Menno
Published: November 2022

Spin qubits in quantum dots define an attractive platform for quantum information because of their compatibility with semiconductor manufacturing, their long coherence times, and the ability to operate above one Kelvin. However, despite demonstrations of SWAP oscillations, the integration of this two-qubit gate together with single-qubit control to create a universal gate set as originally proposed for single spins in quantum dots has remained elusive. Here, we show that we can overcome these limitations and execute a multitude of native two-qubit gates, together with single-qubit control, in a single device, reducing the operation overhead to perform quantum algorithms. We demonstrate single-qubit rotations, together with the two-qubit gates CROT, CPHASE, and SWAP, on a silicon double quantum dot. Furthermore, we introduce adiabatic and diabatic composite sequences that allow the execution of CPHASE and SWAP gates on the same device, despite the finite Zeeman energy difference. Both two-qubit gates can be executed in less than 100 ns and, by theoretically analyzing the experimental noise sources, we predict control fidelities exceeding 99%, even for operation above one Kelvin.
Boosting the photocatalytic performance via isomeric configuration design in covalent organic frameworks
Authors: Yang Fan , Qu Hong-Yan , Guo Yuan , Kan Jing-Lan , Dong Yu-Bin
Published: November 2022

BT-COF1 and BT-COF2 with identical chemical formula but isomeric configurations were synthesized. BT-COF2 with broader absorption range and more evident charge transfer property exhibits superior photocatalytic activity in the oxidation of sulfides.
A novel AIEgen photosensitizer with an elevated intersystem crossing rate for tumor precise imaging and therapy
Authors: Hu Yingcai , Yin Sheng-Yan , Li Zuhao , Qi Wenchen , Chen Yun , Li Jishan
Published: November 2022

An ultraefficient AIEgen photosensitizer (TPE-4QL+) was synthesized based on an alternative elevated intersystem crossing rate for the precise imaging and therapy of tumors.
An NO-responsive probe for detecting acute inflammation using NIR-II fluorescence/optoacoustic imaging
Authors: She Zunpan , Chen Junjie , Sun Lihe , Zeng Fang , Wu Shuizhu
Published: November 2022

An activatable probe for detecting acute inflammation has been developed. Nitrosation turns electron-donating methylamine into electron-withdrawing methyl-N-nitroso with turn-on NIR-II fluorescence and optoacoustic signals for imaging.
A strained intramolecular P/Al-FLP and its reactivity toward allene
Authors: Federmann Patrick , Bosse Tamino , Wolff Siad , Cula Beatrice , Herwig Christian , Limberg Christian
Published: November 2022

An intramolecular P/Al-based FLP with a biphenylene scaffold is synthesized by a convenient Al-Sn exchange. Despite the spacer the FLP functions interact leading to a strained compound, capable of CO2 binding and unprecedented allene activation.
Synthesis of different manganese tungstate nanostructures for enhanced charge-storage applications: theoretical support for experimental findings
Authors: Sardar K. , Thakur S. , Das A. , Besra N. , Banerjee D. , Majumdar G. , Chattopadhyay K. K.
Published: November 2022

Due to the dual features of EDLC and pseudocapacitance the low-temperature developed MnWO4 nanostructures with different aspect ratio showed good electrochemical properties. DFT study provided the quantum capacitance value.
Robust palladium catalysts on nickel foam for highly efficient hydrogenations
Authors: Rahmani Azina , Currie Taylor M. , Shultz Lorianne R. , Bryant Jacob T. , Beazley Melanie J. , Uribe-Romo Fernando J. , Tetard Laurene , Rudawski Nicholas G. , Xie Shaohua , Liu Fudong , Wang Ting-Hsuan , Ong Tiow-Gan , Zhai Lei , Jurca Titel
Published: November 2022

The combination of a polydopamine interface, solvothermal seeding of Pd(OAc)2, and ALD Al2O3 overcoat enables the formation of evenly-coated, ultralow Pd loading Ni foam monolith materials.
Ce1−xSrxO2−δ solid solution supports cobalt-based catalysts for hydrogen production via auto-thermal reforming of acetic acid
Authors: Shu Chenghong , Ding Chenyu , Liu Yan , Sun Wenjing , Huang Jia , Liao Fuxia , Huang Lihong , Wang Ning
Published: November 2022

Auto-thermal reforming (ATR) is an effective route to extract hydrogen from acetic acid (Hac) derived from biomass.
Deep learning for enantioselectivity predictions in catalytic asymmetric β-C–H bond activation reactions
Authors: Hoque Ajnabiul , Sunoj Raghavan B.
Published: November 2022

Molecular descriptors from a mechanistically important metal–ligand–substrate complex are used for the first time to build a Deep Neural Network (DNN) model to predict % ee. Accurate and chemically meaningful predictions could be obtained.
Effects ofDendrobium officinaleultrafine powder on sub-health mice induced by unhealthy lifestyle based on neuroendocrine immune system
Authors: Shi Meng-Lin , Yan Mei-Qiu , Su Jie , Yu Jing-Jing , Ye Sen-Yu , Fu Meng , Hu Xue-Ling , Niu Zhuang-Wei , Wu Wen-Yan , Chen Si-Min , Chen Su-Hong , Chen Jian-Zhen , Lv Gui-Yuan
Published: November 2022

Dendrobium officinalepowder was found to relieve symptoms such as fatigue and depression in sub-health mice by regulating the disorder of the neuroendocrine-immune network.
Towards personalized antibody cancer therapy: development of a microfluidic cell culture device for antibody selection
Authors: Condelipes Pedro G. M. , Fontes Pedro Mendes , Godinho-Santos Ana , Brás Eduardo J. S. , Marques Vanda , Afonso Marta B. , Rodrigues Cecília M. P. , Chu Virginia , Gonçalves João , Conde João Pedro
Published: November 2022

Easy-to-use PDMS/polystyrene microfluidic device for the perfused culture of cancer cells and study of interaction-based therapies, namely phage-cell interactions.
Photo-induced phase-transitions in complex solids
Authors: Rajpurohit Sangeeta , Simoni Jacopo , Tan Liang Z.
Published: November 2022

This review highlights the recent experimental and theoretical advances in ultrafast science in the field of ultrafast sciences, particularly photoinduced phase transitions in complex systems.
A flexible Ni–Ag-coated nylon yarn as an electrode for non-enzymatic glucose sensing
Authors: Li Xiaozhi , Qiao Jutao , Luo Dan , Xu Siyi , Liu Yuefeng , Liu Hao
Published: November 2022

SCNY@Ni was prepared by electrochemical deposition and exhibited excellent performance for glucose determination.
Reliability evaluation of traditional Chinese medicine fingerprints combined with qualitative and quantitative analysis and antioxidant activity to comprehensively evaluate the quality of Citri Reticulatae Pericarpium
Authors: Wang Xinyi , Chang Qian , Lan Lili , Guo Yong , Sun Guoxiang , Li Qian
Published: November 2022

Comprehensive evaluation of Citri Reticulatae Pericapium quality by HPLC, UV and antioxidant activity.
Benzothiadiazole-based fluorophores as efficient non-doped emitters for solution-processed organic light-emitting diodes
Authors: Sudyoadsuk Taweesak , Funchien Patteera , Petdee Sujinda , Loythaworn Thidarat , Chasing Pongsakorn , Waengdongbung Wijitra , Saenubol Atthapon , Hadsadee Sarinya , Jungsuttiwong Siriporn , Promarak Vinich
Published: November 2022

New HLCT fluorophores are synthesized and successfully applied as non-doped emissive layers in solution-processed double-layered OLEDs. These devices exhibit intense yellow-green emission colors with superior performance.
New trifluoromethylated sesquiterpenoids: synthesis, rearrangement, and biological activity
Authors: Gyrdymova Yulia V. , Rumyantcev Roman V. , Esaulkova Yana L. , Belyaevskaya Svetlana V. , Zarubaev Vladimir V. , Kayumov Airat R. , Rubtsova Svetlana A.
Published: November 2022

The tandem isomerization and trifluoromethylation reactions are a simple, convenient, and atom-economical strategy for the synthesis of various products in high yields from simple substrates.
Simultaneous extraction of total polyphenols and triterpenes from leaves ofCeltis sinensisby deep eutectic solvent hybrid system combined with response surface methodology
Authors: Wang Lei , Cao Shiping , Guo Guoqing , Hu Yang , Li Jie , Fang Xianying , Zhao Linguo
Published: November 2022

Efficient extraction of the total polyphenols and triterpenes fromCeltisleaves with multiple DESs by RSM.
Biosynthesis of indole diterpenes: a reconstitution approach in a heterologous host
Authors: Ozaki Taro , Minami Atsushi , Oikawa Hideaki
Published: November 2022

Reconstitution studies applying the 3-stage strategy to the synthesis of highly elaborated indole diterpenes are reviewed.
Infinite building blocks for directed self-assembly of a supramolecular polyoxometalate–cyclodextrin framework for multifunctional oxidative catalysis
Authors: Liu Xiaohui , Zhang Jinlin , Lan Yuxin , Zheng Qi , Xuan Weimin
Published: November 2022

With evolution from polyoxometalate-based molecular building blocks to infinite building blocks (IBBs), a supramolecular polyoxometalate–cyclodextrin framework was constructed by an IBB strategy for multifunctional oxidative catalysis.
Boosting the photocatalytic performance of Cu2O for hydrogen generation by Au nanostructures and rGO nanosheets
Authors: Ma Yujie , Wei Xindong , Aishanjiang Kedeerya , Fu Yi , Le Jiamei , Wu Hailong
Published: November 2022

Au@Cu2O/rGO exhibited boosting photocatalytic performance due to the yolk–shelled structure, abundant hot charges on Au, and quick charge transfer by rGO.
Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens
Authors: Al-Warhi Tarfah , Elimam Diaaeldin M. , Elsayed Zainab M. , Abdel-Aziz Marwa M. , Maklad Raed M. , Al-Karmalawy Ahmed A. , Afarinkia Kamyar , Abourehab Mohammed A. S. , Abdel-Aziz Hatem A. , Eldehna Wagdy M.
Published: November 2022

As promising antimicrobials against MDR pathogens, two novel series of isatin thiazolyl-pyrazoline conjugates were developed. Compounds 9f and 10h were the most effective against the tested MDR strains.
Water splitting by MnFe2O4/Na2CO3 reversible redox reactions
Authors: Deng Yimin , Li Shuo , Dewil Raf , Appels Lise , Yang Miao , Zhang Huili , Baeyens Jan
Published: November 2022

Investigating H2 production by MnFe2O4/Na2CO3/H2O redox cycles, using different reactants. Using the more efficient coprecipitated reactant, production costs will be ∼1€ per kg H2, if 120 cycles are achieved. Improving the cheaper ball-milled reactant is recommended.
In-depth drug delivery to tumoral soft tissuesviapH responsive hydrogel
Authors: Sarwar Shumaila , Bashir Sajid , Asim Mulazim Hussain , Ikram Fakhera , Ahmed Arsalan , Omema Ume , Asif Anila , Chaudhry Aqif Anwar , Hu Yong , Ustundag Cem Bulent
Published: November 2022

A pH responsive nanoparticle–hydrogel hybrid drug delivery system was investigated for in-depth anticancer drug delivery to solid tumours.
Photoelectrochemical performance of a spin coated TiO2 protected BiVO4-Cu2O thin film tandem cell for unassisted solar water splitting
Authors: Sitaaraman S. R. , Nirmala Grace Andrews , Sellappan Raja
Published: November 2022

Mo-BiVO4/TiO2/FeOOH photoanode–Cu2O/TiO2/MoS2 photocathode tandem cells with photoelectrochemical stability testing.
Ligand functionalization of defect-engineered Ni-MOF-74
Authors: Lim Jaewoong , Lee Seonghwan , Sharma Amitosh , Seong Junmo , Baek Seung Bin , Lah Myoung Soo
Published: November 2022

Ni-MOF-74 incorporated with functionalized ligand fragments exhibits modified porosity and CO2 adsorption depending on the amount of fragment and the type, position, and size of the functional groups.
One-pot chlorocarboxylation of toluenes with chlorine dioxide under photoirradiation
Authors: Ohno Shohei , Asahara Haruyasu , Inoue Tsuyoshi , Ohkubo Kei
Published: November 2022

Chlorine dioxide radical (ClO2˙) under photoirradiation induces the chlorocarboxylation of toluene in a single step to produce 2- and 4-chlorobenzoic acids.
Correction: The role of electrochemical biosensors in SARS-CoV-2 detection: a bibliometrics-based analysis and review
Authors: Mao Shuduan , Fu Li , Yin Chengliang , Liu Xiaozhu , Karimi-Maleh Hassan
Published: November 2022

Correction for ‘The role of electrochemical biosensors in SARS-CoV-2 detection: a bibliometrics-based analysis and review’ by Shuduan Mao et al., RSC Adv., 2022, 12, 22592–22607, https://doi.org/10.1039/D2RA04162F.
Organic photovoltaic performance and structural relationship of non-fullerene small molecule acceptors based on a tetraarylphenazine core and perylene diimide
Authors: Xiao Jing , Yu Hui-Juan , Xie De-Xun , Shinohara Akira , Fan Ting , Yi Jicheng , Lai Joshua Yuk Lin , Shao Guang , Yan He
Published: November 2022

Two small molecular acceptors based on perylene diimide tetramer with a phenazine core and benzene or thiophene linkers are developed.
Polypropylene separator-reinforced polymer-in-salt solid composite electrolytes for high-performance lithium ion batteries at room temperature
Authors: Shi Kun , Zheng Dawei , Guo Zhiming , Yang Zeheng , Zhang Weixin
Published: November 2022

Polypropylene separator-reinforced polymer-in-salt SSCEs combine high ionic conductivity, largetLi+and superior interface stability toward lithium anodes, enabling excellent cycling stability of solid-state lithium ion batteries at room temperature.
Multiple boosting Janus membranes synergized with Li-rich PAF-6 and carbon nanoparticles for high performance lithium–sulfur batteries
Authors: Zhu Kewei , Li Zhangnan , Yu Mengxuan , Liu Baijun , Sun Zhaoyan , Hu Wei , Zhu Guangshan
Published: November 2022

Li-rich PAF-6 synergized with CNs afforded efficient transfer channels for Li+, effectively preventing polysulfide dissolution and shuttle. The introduced –SO3H can also inhibit the shuttle effect. An excellent capacity retention rate of 85% after 100 cycles was achieved.
A 2D copper-imidazolate framework without thermal treatment as an efficient ORR electrocatalyst for Zn–air batteries
Authors: Franco Ana , Salatti-Dorado José Ángel , García-Caballero Valentín , Lorca Sebastián , Camacho Luis , Cano Manuel , Fernández-Romero Antonio J. , Delgado Juan J. , Giner-Casares Juan J. , Carrillo-Carrión Carolina
Published: November 2022

A novel water-stable 2D Copper-Imidazolate Framework (2DCIF) exhibits outstanding electrocatalytic activity for the oxygen reduction reaction without the need for calcination. These 2DCIFs have been successfully used as air electrodes in Zn–air batteries.
Transparent conductive oxide type materials as the anode of solid oxide fuel cells at a reduced temperature
Authors: Zhang Xuelin , Zhang Yuan , Ni Jiupai , Irvine John T. S. , Ni Chengsheng
Published: November 2022

ZnGa2O4 reduced at high temperature led to the formation of anti-site defects, which resulted in high electrical conductivity and enabled it to obtain excellent electrochemical performance as a SOFC anode.
Bandgap engineering of covalent organic frameworks for boosting photocatalytic hydrogen evolution from water
Authors: Chen Yuxiang , Luo Xiao , Zhang Jiejie , Hu Lu , Xu Ting , Li Wei , Chen Lei , Shen Mao , Ren Shi-Bin , Han De-Man , Ning Guo-Hong , Li Dan
Published: November 2022

A simple and efficient way was developed to enhance the visible-light-driven water-splitting performance by varying the number of β-ketoenamine linkages in covalent organic frameworks.
Visible light-activated photocatalytic activity of TiO2–crystal violet based superhydrophobic paint against VOCs in indoor air
Authors: Anus Ali , Le Van Cam Thi , Sheraz Mahshab , Kim Seungdo , Lee Woo Ram
Published: November 2022

Visible-light-activated photochemical degradation against VOCs in indoor air using TiO2 nanoparticles encapsulated crystal violet.
Multiview subspace clustering via low‐rank correlation analysis
Authors: Kun Qu , Abhadiomhen Stanley Ebhohimhen , Liu Zhifeng
Published: November 2022

In order to explore multi‐view data, existing low‐rank‐based multi‐view subspace clustering methods seek a common low‐rank structure from different views. However, in real‐world scenarios, each view will often hold complex structures resulting from noise or outliers, causing unreliable and imprecise graphs, which the previous methods cannot effectively ameliorate. This study proposes a new method based on low‐rank correlation analysis to overcome these limitations. Firstly, the canonical correlation analysis strategy is introduced to jointly find the low‐rank structures in different views. In order to facilitate a robust solution, a dual regularisation term is further introduced to find such low‐rank structures that maximise the correlation in respective views much better. Thus, a unifying clustering structure is then integrated into the model to characterise the connections between different views adaptively. In this way, noise suppression is achieved more effectively. Furthermore, we avoid the uncertainty of spectral post‐processing of the unifying clustering structure by imposing a rank constraint on its Laplacian matrix to obtain the clustering results explicitly, further enhancing computation efficiency. Experimental results obtained from several clustering and classification experiments performed using 3Sources, Caltech101‐20, 100leaves, WebKB, and Hdigit datasets reveal the proposed method's superiority over compared state‐of‐the‐art methods in Accuracy, Normalised Mutual Information, and F‐score evaluation metrics.
Transgender Medicine and Risk of Venous Thromboembolism
Authors: Bunderen C.C. Van , Leentjens J. , Middeldorp S.
Published: November 2022

Gender dysphoria refers to psychological distress that results from an incongruence between gender identity and sex assigned at birth. Administration of sex hormones is most often used as a first step to develop and maintain physical characteristics consistent with gender identity. Gender-affirming hormone treatment is considered beneficial for the quality of life and reduction of depression. However, estrogen and androgen-lowering hormone therapies used in transwomen are in particular associated with increased risk of venous thromboembolism. In this review, introduced by a clinical case, we provide an overview of the currently available medical therapies in transgender medicine, and put the associated increased risk of venous thromboembolism into perspective.
Tierärztliches Meinungsbild zur Equinen Lyme-Borreliose – Ergebnisse einer Fragebogenstudie
Authors: Gehlen Heidrun , Inerle Katharina Sophie , Briese Beatrice
Published: November 2022

Ziel Erfassung des tierärztlichen Meinungsbildes zur Equinen Lyme-Borreliose

Material und Methoden Durch eine Befragung wurde untersucht, wie Pferdetierärzte die Bedeutung positiver serologischer Nachweise gegen Borrelia burgdorferi (Bb-AK) und einer klinisch manifesten Lyme-Borreliose (LB) einschätzten sowie letztere diagnostizieren und therapieren.

Ergebnisse Der Fragebogen wurde von 73 Tierärzten (TÄ) ausgefüllt. 48 % der TÄ erhoben nur sehr selten bis gar keine serologischen Bb-AK-Nachweise bei Pferden in ihrer Praxis, 47 % stellten gelegentlich Bb-AK fest und nur 5 % fanden häufig Bb-AK-Nachweise. 51 % der TÄ bestätigen, dass sie bereits klinisch-manifeste LB-Erkrankungen festgestellt hätten, während 43 % die Existenz dieser Erkrankung zwar nicht ausschlossen, aber selber keine Equine Lyme-Borreliose Fälle gesehen haben. 6 % der TÄ zweifeln die Existenz einer klinischen LB beim Pferd generell an.

Im Durchschnitt wurden 159-mal im Jahr weiterführende diagnostische Maßnahmen im Hinblick auf eine LB eingeleitet, und es wurden 1,4 ± 1,0 Fälle von equiner LB im Jahr diagnostiziert. Als Untersuchungsmethoden zur Abklärung von Borreliose-Verdachtsfällen verwendeten 68 % der TÄ den „indirekten Erregernachweis“, 27 % sowohl den direkten als auch den indirekten Erregernachweis und 5 % verwendeten ausschließlich den direkten Erregernachweis. Bei letzterem wurden am häufigsten Blut und Hautstanzen als Probenmaterial eingesandt.

Die Behandlung von Pferden mit auf eine Borrelioseerkrankung hinweisenden Laborergebnissen und als passend bewerteter, klinischer Symptomatik erfolgte durch 93 % der Tierärzte mit Antibiotika und 7 % mit Homöopathie. Am häufigsten wurde Doxycyclin (68 %) eingesetzt. Dabei erfolgte die antibiotische Behandlung über einen Zeitraum von 3 (31 %) bis 4 (63 %) Wochen.

In Bezug auf eine mögliche Impfung der Pferde gegen Borreliose boten 39 % der Tierärzte diese Impfung nicht an, bei 20 % wurde sie noch nicht eingesetzt, aber auch nicht kategorisch abgelehnt und 41 % führten regelmäßig Borreliose-Impfungen durch.

Schlussfolgerung und klinische Relevanz Das Meinungsbild von praktizierenden Pferdetierärztinnen und Pferdetierärzten in Deutschland zur klinischen Relevanz der equinen LB ist sehr heterogen. Einheitliche Richtlinien hinsichtlich Diagnostik- und evtl. auch Therapieempfehlungen wären sinnvoll, um der Unsicherheit in der Tierärzteschaft entgegenzuwirken.