bluuebunny/crossref_metadata_2025 huggingface dataset:
НЭО G3 — новая подгруппа, новые подходы
Authors: Евдокимова Е. В. , Артамонова Е. В. , Делекторская В. В. , Чемерис Г. Ю.
Published: November 2021

Введение: Подгруппа нейроэндокринных опухолей (НЭО) G3 впервые была выделена в 2017 году. Данная подгруппа опухолей отличается от смежных групп НЭО G2 и крупноклеточных нейроэндокринный карцином (КНЭК) по своим молекулярным и морфологическим свойствам. Эта группа характеризуется индексом ki-67>20% и отсутствием мутаций p53 и Rb, которые характерны для нейроэндокринных карцином (НЭК), но отсутствуют в группе НЭО. Опухоли группы НЭО G3 характеризуются менее благоприятным течением, чем опухоли группы НЭО G2, но, тем не менее, протекают значительно более благоприятно, нежели НЭК. К сожалению, на сегодняшний день не существует единого стандарта лечения для данной группы пациентов.Цели и задачи: 1) определение иммуногистохимического статуса рецепторов соматостатина в новой группе НЭО G3; 2) оценка эффективности режимов химиотерапии 1-й линии в комбинации с терапией аналогами соматостатина.Материалы и методы: В исследование включено 53 пациента с диагнозом НЭО G3 (медиана ki-67 36,4% [21,0–60,0%]). В 1 линию лечения пациентам проводилась химиотерапия (ХТ) 1-й линии Аранозой (n =19) или в режиме XELOX (n =8) или TemCAP (n =11) или платиносодержащими режимами (n =10) в комбинации с аналогами соматостатина (АС). Анализ базы данных проведен с помощью программы IBM SPSS Statistics версия 26.0.0.0.Заключение: Экспрессия РСС 2 и/или 5 типа выявлена в 64,1% (n =34) случаев НЭО G3. Наличие экспрессии рецепторов соматостатина в опухоли позволило добавить терапию АС к системной ХТ. Медиана выживаемости без прогрессирования (ВБП) в группе Аранозы +АС составила 12,0 ± 5,1 месяцев (95%ДИ: 1,9–22,0), в группе XELOX +АС — 5,0 ± 2,0 месяцев (0,9–9,0), в группе TemCAP +АС — 11,0 ± 8,4 месяцев (1,6–27,4) и в группе платиносодержащих комбинаций +АС — 4,0 ± 1,3 месяца (1,4–6,6), статистическая значимость не достигнута (p =0,3). Частота контроля заболевания (ЧКЗ) в группе Аранозы + АС составила 73,6 %, частота объективных ответов (ЧОО) — 36,8 %, прогрессирование заболевания (ПЗ) наблюдалось в 21,1% случаев. В группе XELOX +АС ЧОО составила 62,5%, стабилизация болезни наблюдалась в 50,0% случаев, ПЗ в 25,0%. В группе TemCAP +АС ЧКЗ составила 63,6%, ЧОО наблюдался в 9,1%, ПЗ в 18,2% случаев. В группе платиносодержащих режимов +АС стабилизация болезни наблюдалась в 40,0% случаев, ПЗ было отмечено в 50,0% случаев (p =0,05). В результате комбинированного действия двух групп препаратов была достигнута максимальная эффективность лечения данных пациентов.
Практические рекомендации по лечению злокачественных опухолей головы и шеи
Authors: Болотина Л. В. , Владимирова Л. Ю. , Деньгина Н. В. , Новик А. В. , Романов И. С.
Published: November 2021

.
Практические рекомендации по лекарственному лечению больных гепатоцеллюлярным раком
Authors: Бредер В. В. , Балахнин П. В. , Виршке Э. Р. , Косырев В. Ю. , Ледин Е. В. , Петкау В. В.
Published: November 2021

.
Практические рекомендации по коррекции нефротоксичности противоопухолевых препаратов
Authors: Громова Е. Г. , Бирюкова Л. С. , Джумабаева Б. Т. , Курмуков И. А.
Published: November 2021

.
Avances en el Trabajo de las Fuerzas Militares de Colombia en torno a la Equidad de Género, el Enfoque Diferencial y la Prevención de Violencia basada en Género
Authors: Perdomo Ramos Tania Paola
Published: November 2021

Este artículo tiene por objeto evidenciar algunos avances que las FF.MM. de Colombia han llevado a cabo en la inserción de conceptos como la equidad de género, el enfoque diferencial y la violencia de género, los cuales dan paso a manuales de función y operación de las diferentes fuerzas en torno a ellos. Como conclusión, se evidencia que la aplicación de estos conceptos necesariamente ha de ir más allá de la creación de una política pública, puesto que quedan al descubierto desafíos no sólo en materia de equidad de género, sino también en lo relacionado con el andamiaje institucional del país y sus procesos.
Penyelesaian Sengketa Hak Milik atas Tanah dalam Perkawinan Campuran di Indonesia
Authors: Prastyawan Yoga Nasa
Published: November 2021

Penelitian ini secara objektif bertujuan untuk menemukan dasar hukum pembuatan penetapan pisah harta pada perkawinan campuran tanpa perjanjian kawin di Indonesia dan untuk mengetahui penyelesaian sengketa hak milik atas tanah pada perkawinan campuran tanpa perjanjian kawin di Indonesia. Jenis penelitian ini adalah penelitian hukum normatif, dengan bahan penelitian berupa bahan primer, bahan sekunder, dan bahan tersier. Teknik pengumpulan data berupa studi pustaka dan data pendukung diperoleh dengan melakukan wawancara kepada Ibu Pujiastuti, S.H, selaku Notaris. Teknik analisis data secara deskriptif dengan cara pengolahan data menggabungkan data primer, data sekunder, dan data tersier. Hasil penelitian secara deskriptif yang pertama menunjukkan bahwa Dasar hukum pengajuan permohonan pisah harta pada perkawinan campuran dapat menggunakan ketentuan Pasal 186 KUHPerdata. Putusan Mahkamah Konstitusional Nomor 69/PUU/XIII/2015 dan yurisprudensi dari Penetapan Pengadilan Negeri Bekasi Nomor 67/PDT.P/2014/PN.Bks. Hasil penelitian yang kedua penyelesaian sengketa hak milik atas tanah pada perkawinan campuran tanpa perjanjian kawin di indonesia dengan mengajukan permohonan pisah harta oleh salah satu pasangan suami-isteri ke pengadilan sesuai kopetensi relatifnya. Penyelesaian ini menurut peneliti adalah satu-satunya cara yang terbaik dan legal dimata Hukum
Anxieties of secondary school students during distance learning in COVID-19 pandemic
Authors: Bülbül Ali Haydar , Demirbaş Gonca , Odabaşi Hatice Ferhan
Published: November 2021

As a result of increasing COVID-19 cases all over the world, schools continued to provide education distantly since the beginning of 2020. This immediate shift is considered as both a factor of anxiety and an area of anxiety. This study aims to investigate the underlying reasons of anxieties among secondary school students with regard to five dimensions: health-related issues, technological opportunities, domiciliary conditions, course-related issues and privacy-related issues. A survey design was adopted. The research was carried out with participation of 156 secondary school students of a state school in Istanbul. Data was collected through the Anxiety Sources Questionnaire in Distance Education developed by the researchers. The underlying reasons of anxiety of secondary school students is presented under five categories. The results revealed that students were mainly concerned about face-to-face exams; problems related to devices; isolation; their inefficiency to learn the content and sharing their private settings.

Keywords: Anxiety; COVID-19 pandemic; Distance education; Secondary school students.
Mercado Minorista de Abastos de La Victoria
Authors:   , Lucar Figueroa Eugenio Javier
Published: November 2021

El proyecto del Mercado Minorista de Abastos de La Victoria se lleva acabo con la consigna de aportar una nueva infraestructura que además de ser un equipamiento vital para la vida de la gente, permita dar una puesta en valor del espacio público y refuerce la identidad del lugar. La tipología de mercado en este caso minorista tiene una influencia limitada, pero permite generar un orden en el patrón de la actividad comercial de abasto ausente en gran parte de La Victoria. Por eso se optó por emplazarlo en un lugar donde estuvieran implicados usos adecuados para la actividad y sobre todo tenga un impacto positivo entre los dos asentamientos humanos más importantes del distrito como San Cosme y El Pino. Lo esencial de este proyecto es integrar el mercado con sus bordes a fin de darle animación y tener una experiencia continua en toda la trama influenciada por el proyecto. En conclusión, el nuevo mercado a desarrollar incluye una preocupación por regirse a los parámetros de un sistema de abasto adecuado, además de ofrecer infraestructura optima y servicios complementarios.
El impacto de las TIC en la formación de los estudiantes de los cursos de Lectura Musical y Entrenamiento Auditivo en una escuela de música en Lima (2009-2020)
Authors:   , Lescano Contador Juan Alfonso
Published: November 2021

El presente trabajo de investigación busca conocer el nivel de impacto que tienen las Tecnologías de Información y Comunicación (TIC) en la formación de los estudiantes de los cursos de Lenguaje Musical y Entrenamiento Auditivo (LEA) pertenecientes a una escuela de música en Lima. Para ello, en primer lugar, se realiza una descripción sobre las herramientas tecnológicas que están incorporándose en la educación superior musical, así como las metodologías modernas que las respaldan, como serían el b-learning, el e-learning, y el m-learning. En segundo lugar, se efectúa un análisis de los cursos de LEA a partir de su metodología aplicada y de las herramientas tecnológicas que ofrecen para el aprendizaje del estudiante. Para recopilar esta información se realizaron entrevistas a los docentes de las asignaturas, al director de la carrera, al experto en metodologías e-learning y b-learning Daniel Ravelo, y al músico y docente de la Universidad de Chile y Universidad Católica de Chile, Winston Moya. Asimismo, fueron realizadas encuestas a los alumnos de LEA, y dos focus group, uno con 9 estudiantes de quinto y sexto ciclo, y otro con 5 egresados de la carrera. Los resultados encontrados mostraron la necesidad de implementar nuevas y mejores herramientas tecnológicas a los cursos previamente mencionados, por lo que se propone finalmente el diseño de un aplicativo digital innovador.
La gestión comunicacional en el proceso de fusión empresarial de Cassinelli y Celima-Trébol en relación con los activos intangibles
Authors:   , Del Mar Rojas Ana Ester
Published: November 2021

El presente trabajo de investigación aborda la importancia de la gestión comunicacional en los procesos de fusión empresarial, basado en la dinámica de dos organizaciones peruanas. Asimismo, analiza los impactos en términos de imagen y reputación interna. El objetivo general ahonda en la investigación de los impactos de la ausencia de la gestión comunicacional en procesos de fusión empresarial entre Cassinelli y Celima-Trébol, con el fin de identificar la relación causa-efecto entre dichas variables. El Marco Teórico ha sido estructurado de manera que muestre el sentido y relación de los procesos de fusión empresarial con la comunicación. En ese sentido, se exponen las diferentes definiciones, clasificaciones y características de las fusiones empresariales. Así mismo, se muestra cómo es que una fusión organizacional puede presentarse como estrategia para el crecimiento externo de la empresa, las posibles consecuencias organizativas producto de ellas y su impacto en los activos intangibles a nivel interno. Por último, se expone el concepto de Gestión Empresarial, sus niveles dentro de una organización, las etapas y ventajas de este. Luego, se abordan los temas de la Gestión Comunicacional, en términos de Comunicación e Identidad Corporativa, activos intangibles, Imagen y Reputación Corporativa, con el objeto de relacionarlos con el proceso de fusión en empresas de mejoramiento del hogar en el Perú. En el capítulo tres, se exponen los Hallazgos y Resultados producto de la realización de entrevistas en profundidad aplicada a los altos mandos de la organización y encuestas a una muestra representativa de colaboradores, la cual buscó de manera directa identificar los impactos de la ausencia de una gestión comunicacional en el proceso de fusión empresarial. Por último, se presentan las principales conclusiones derivadas del presente trabajo de investigación, en las que se evidencia la inexistencia de una adecuada estrategia comunicacional entre ambas marcas y un arduo proceso de adaptación basado en un nuevo ambiente laboral y; se exponen las recomendaciones que demuestran la relevancia de la gestión comunicacional en el desarrollo de la fusión empresarial.
Development of Physics-Based Morphology Model with an Emphasis on the Interaction of Incoming Waves with Transient Bed Profile due to Scouring and Accretion using Dynamic Mesh
Authors: Cho Yong Jun
Published: November 2021

A physics-based morphology model [Seoul Foam] was developed using the dynamic mesh technique to explain the interaction between the sea bed, which undergoes deformation due to siltation and scouring, and the incoming waves. In doing so, OlaFlow, an Open Foam-based toolbox, was used as a hydrodynamic model. To verify the proposed physically-based morphology [Seoul Foam] in this study, numerical simulations of the shoaling process over the beach of the uniform slope were implemented. The numerical result shows that the formation process of a sand bar over the foreshore was successfully simulated. As can be easily anticipated, the size of the sand bar was closely linked to the nature of incoming waves, and in the case of a rough sea, the foreshore slope was rapidly deformed due to scouring. In mild seas, several sand waves were formed near the shoreline, and when the exposure time was the same, the size of the sand waves was not as large as in rough seas.
Hidden Markov Model(HMM)-Based Fishing Activity Prediction Using V-Pass Data
Authors: Park Ju-Han , Jeon Ho-Kun , Yang Chan-Su
Published: November 2021

Illegal fishing has been a serious threat to the conservation of seafood resources and provoked the importance of marine surveillance. There are several types of fishing vessel monitoring systems operated by Republic of Korea, for example, Vessel Monitoring System(VMS), Automatic Identification System (AIS), V-Pass and VHF-DSC. However, those methods are not adaptable directly to fishing activity monitoring. The limitation requires more human resources to determine fishing status. Thus, this study proposes a method of estimating fishing activity from V-Pass, fishing vessel position reporting system, using Hidden Markov Model (HMM). HMM is a model to determine status through probability distribution for a sequence of time-series data. First of all, fishing activity status was labeled on V-Pass data. The distribution of speed on fishing activity was computed from the labeled data and HMM was constructed from the data obtained at Socheongcho Ocean Research Station (SORS). The model was first applied to the data of SORS for a test, and then Busan for validation. The model showed 99.4% and 89.6% as test and validation accuracy, respectively. It is concluded that the HMM can be applicable to predict a fishing activity from vessel tracks.
Salinity drift prevention experiments in the Korea ocean research stations and suggestions for high quality salinity observation
Authors: Lee Jaeik , Lee Suchan , Jeong Jongmin , Min Yongchim , Jeong Jin-Yong , Kim Yong Sun
Published: November 2021

The importance of salinity has been highlighted to cope with climate changes and disaster prevention. The salinity of accuracy up to 0.005 is normally required in an open ocean to understand various oceanic and climatic phenomena; however, the reliability of salinity measured on the coast and open seas around Korea was low due to the lack of a standardized observation system and post-processing of quality verification. Korea Ocean Research Stations (KORS) has been producing salinity time series since 2003 through the Aanderaa conductivity-temperature (CT) 3919 inductive sensors, which have an advantage of on-site maintenance but tend to drift toward a lower conductivity because of biological attachments to the sensor. This study applied copper taping and UV light exposure techniques to the sensors and then compared its salinity measurements with RBR CTD mooring observations and SeaBird19 CTD profiles to assess a biofouling effect on salinity observations. This experiment shows that the salinity from the CT sensor without biofouling prevention starts to drift in a week, particularly for a surface sensor. This biofouling induced the decrease of salinity up to 10 in a month. The copper taping methodology efficiently suppressed the biological attachment but disturbed an electromagnetic field around the sensor, thus resulting in unrealistic salinity values. When UV light was periodically exposed at a distance of about 5 cm away from the CT sensor, relatively stable salinity could be observed without significant drift at least in two months. Besides, the SBE37 CTD, an electrode-type sensor, seems to be relatively free from biofouling but has difficulties in sensor maintenance and a sensor calibration process. Our results underline a double installation of salinity observation equipment with UV light exposure. In addition, the pre-calibration of a CT(D) sensor and post-verification should be included in a standard procedure for high-quality salinity measurement.
ACTIVE METHODOLOGIES IN HEALTH EDUCATION FOR THE ELDERLY: a literature review
Authors: Pessoa Borges Ana Kleiber , Brito Ana Gabriela Ferreira , Brilhante Batista Ilaíse , Marinho Jéssica da Silva , Costa Erenilde Barbosa da Silva , Melo Mislene Ferreira Xavier de
Published: November 2021

This research aimed to analyze the practices in active methodologies used in health education for the elderly. The sample search was carried out in the LILACS, SciELO, CAPES journals and Google Scholar search databases. Seven articles were selected and their analysis resulted in the categories “the use of active methodologies for teaching health to the elderly” and “the use of the main active methodologies in the training of academics, professionals and caregivers”. Current social demands require teaching methodologies that enable critical, reflective and problematizing training. The need for more research on this topic is suggested, both in the academic sphere and in other teaching contexts, such as health and permanent education.
“PLANTÃO DA CIDADE”: a study of local political participation and the constitution of subjectivities through Facebook
Authors: Rodrigues Hila , Melo Isabela
Published: November 2021

The purpose of this article is to discuss the act of political participation by citizens mediated by communication technologies. It is an effort to understand the potential scenarios and paths for the promotion of citizen participation in the sphere of public power. The investigation took place through the observation of a specific space on Facebook: the Plantão da Cidade group, conceived in the municipality of Ouro Preto to enable political discussions. The proposed exam highlights the possibilities offered by the online environment to ensure the political participation of ordinary people in municipal management decisions and the mobilization of local community actions.
O CORPO EM MOVIMENTO NO CARIMBÓ: uma contribuição no Desenvolvimento Sensório-Motor em Educação Física na Educação Infantil em Belém (PA)
Authors: Azevedo Ana D'Arc Martins , Neiva Camila Rodrigues Neiva , Chagas Junior Edgar Monteiro Chagas Junior , Arroyo Maria Betânia de Carvalho Fidalgo Arroyo
Published: November 2021

Este artigo destaca o Carimbó como símbolo da cultura tradicional e identidade paraense, um instrumento para trabalhar a teoria de Wallon sobre o desenvolvimento sensório-motor. Teve como problemática, conhecer a maneira que o Carimbó contribui para o desenvolvimento sensório-motor em alunos da Educação Infantil (maternal) nas aulas de Educação Física. A pesquisa qualitativa do tipo Estudo de Caso, utilizou a observação participativa e a entrevista aberta com uma professora e seis alunos. Para a análise dos dados, foi utilizada a Triangulação de Dados. Como resultados, compreendemos que o Carimbó viabilizou o desenvolvimento sensório-motor dos alunos, pois foi possível observar o desenvolvimento dos aspectos pesquisados.
SPECIFIC AND DIFFERENTIATED EDUCATION: cultural complexes of the Haliti-Paresi mother tongue
Authors: Ferreira Waldinéia Antunes de Alcântara , Zonizokemairô Nilce
Published: November 2021

This article presents some reflections related to mother tongue teaching with the Haliti - Paresi people. It is the result of some questions raised from the classes at the Post-Graduation Stricto Sensu Professional Master in “Teaching in Indigenous Intercultural Context” - UNEMAT, about significant pedagogical practices within the context of the specific, differentiated, intercultural and bilingual school. It addresses the place of the mother tongue in the school and its cultural complexes constituted by stories, memories and its own culture. Localizes the mother tongue as a language of instruction at school, as a linguistic ethnopolitics and as a fundamental factor of ethnic identity.
Regional Differences in Control Operations During the 2019-2021 Desert Locust Upsurge
Authors: Retkute Renata , Hinton Rebekah G.K. , Cressman Keith , Gilligan Christopher A.
Published: November 2021

The desert locust remains a major threat to global food security. Control operations are a crucial tool to manage crisis; this research investigated the nature of control operations conducted between 2019-2021. Historical data on desert locust and control operations were obtained from the survey reports at the FAO Locust Hub and analysed with respect to survey reports, land cover types, cropland/rangeland extent and crop productivity data. We found that 16.1% of the grid cells with locust presence and 14.9% of the grid cells with control operations had a proportion of rangeland higher than 0.75; while 13.3% of the grid cells with locust presence and 13.2% of the grid cells with control operations had a proportion of croplands higher than 0.75, highlighting that locust presence and control operations were reported in both rangeland and cropland. Control operations continue to be used both to reduce overall locust numbers and to protect crops. Furthermore, through identifying which crops were most at risk, our analyses indicate that wheat production was under the highest strain during periods of increased locust infestations.
Problem Solving Ability Analysis Assessed From Self-Efficacy in The Missouri Mathematics Project Learning Model
Authors: Rini Zulmi Roestika , Purwanti Kartika Yuni
Published: November 2021

Abstrack

This study has purposes, namely to test the effectiveness of the MMP learning model on problem-solving abilities and to describe problem solving abilities in terms of self-efficacy. The benefits of this research are (1) Students get meaningful knowledge to develop problem-solving skills through the MMP learning model (2) Teachers can choose the right learning model to develop problem solving abilities (3) Provide an overview to the teachers about problem solving abilities in terms of self-assessing student’s efficacy. The results showed that: (1) the MMP learning model was effective on problem solving abilities, (2) a) high self-efficacy’ students could understand problems, plan problem-solving, and implement problem-solving plans, as well as re-examine correctly and completely. b) moderate self-efficacy’s students could understand problems, plan problem-solving, implement problem-solving’s plan correctly but not yet completely, re-examine but not yet able to use other methods. c) low self-efficacy’s students could understand problems and plan problem-solving correctly but incompletely, less able to carry out problem-solving plans, but unable to re-examine and use other methods. Based on data and research findings regarding problem-solving abilities in terms of student self-efficacy in MMP learning, it can be recommended: (1) Teachers should guide and help developing the low self-efficacy’s students problem-solving abilities to further improve their abilities. (2) Measuring the students’ self-efficacy even involving a psychological institution in every school is important, so that each school has self-efficacy’s data to provide treatment to the students. (3) The low self-efficacy’s students need further treatment by cultivating confidence and giving direction that they are able to learn mathematics, improving problem solving skill and not prioritizing memorization in learning mathematics.
Penerapan Sistem Informasi Akuntansi Di Bagian Umum Kantor Walikota Medan
Authors: Fahri Zukhruf , Nasution Juliana
Published: November 2021

Tujuan dari penelitian ini adalah untuk mengetahui dan memahami bagaimana penerapan Sistem Informasi Akuntansi (SIA) di Kantor Walikota Medan terkhusus di sub bagian umum keuangan. Penelitian ini termasuk kategori penelitian deskriptif dengan menggunakan metode pendekatan kualitatif. Peneliti mendapatkan hasil penelitian yakni penerapan sistem informasi akuntansi di Bagian Umum Kantor Walikota Medan yaitu menggunakan Sistem Informasi Manajemen Daerah (SIMDA) Keuangan yang sudah terlaksana namun masih ada beberapa kendala atau hambatan dalam penerapannya. Adapun kendala atau hambatan yang ditemukan peneliti yaitu Sumber Daya Manusia (SDM) yang masih sedikit handal dalam mengoperasikan aplikasi SIMDA Keuangan, belum terintegrasi dengan seluruh Satuan Kerja Perangkat Desa (SKPD) secara online, dan tidak adanya Surat Keputusan (SK) Walikota Medan untuk pembentukan Tim Pengelola SIMDA Keuangan. Dari hasil penelitian maka dapat disimpulkan bahwa penerapan SIA berupa Sistem Informasi Manajemen Daerah (SIMDA) Keuangan sudah berjalan namun ada beberapa kendala ataupun hambatan  yang harus diperbaiki agar penerapan SIMDA Keuangan dapat berjalan secara optimal dan sesusai dengan yang diharapkan.
Strategi Going Concern Pedagang Mlijo Pada Masa Pandemi
Authors: Wahyu Setiyowati Supami
Published: November 2021

Tujuan dari penelitian ini adalah untuk mengetahui penerapan prinsip going concern dan kendala yang dialami oleh Mlijo atau pedagang pedang keliling selama masa covid 19. Lokasi penelitian berada di Kelurahan Cemorokandang, Kecamatan Kedungkandang, Kota Malang. Metode penelitian yang digunakan adalah pendekatan kualitatif dengan pendekatan deskriptif. Informan yang dipilih adalah 4 pedagang Mlijo. Teknik pengumpulan data yang digunakan adalah reduksi data, pemaparan data, dan penarikan kesimpulan data. Hasil kajian menunjukkan bahwa kondisi pedagang Mlijo di masa pandemi Covid 19 sudah menerapkan prinsip going concern meski perkembangannya kecil. Pedagang Mlijo menerapkan prinsip going concern dalam usaha dagang dan ekonomi keluarga. Strategi kelangsungan bisnis perdagangan dengan mengutamakan barang yang dipesan oleh pembeli dan menambahkan barang yang sedang tren atau musiman. Pengelolaan ekonomi keluarga meliputi pengelolaan keuangan keluarga dengan mengutamakan kebutuhan yang dianggap penting agar pengeluaran tidak melebihi pendapatan. Pengeluaran keluarga meliputi alokasi keuangan untuk kebutuhan makan sehari-hari, biaya pendidikan anak,  pembayaran cicilan pinjaman, dan tabungan.
MENINGKATKAN MOTIVASI BELAJAR MENGGUNAKAN MEDIA PEMBELAJARAN METODE SYDW PADA PELAJARAN MATEMATIKA DI SMPN 3 PAREPARE
Authors: Sofyan Edy , Gusniwati Gusniwati , Buhaerah Buhaerah
Published: November 2021

Pemanfaatan dan sosialisasi video instruksional adalah solusi efektif untuk pembelajaran online selama pandemi Covid-19. Video pembelajaran ini berbantuan aplikasi YouTube dan WhatsApp. Penggunaan aplikasi ini dapat membantu siswa berpartisipasi dalam kegiatan selama pandemi Covid-19.Selain itu, aplikasi YouTube dan WhatsApp juga dapat memberikan inovasi bagi guru untuk mengembangkan media pembelajaran online. Metode yang digunakan adalah SYDW (Sharing to Youtube and Discussion in WhatsApp ). Kegiatan ini dilaksanakan di UPTD SMPN 3 Parepare, Kecamatan Bacukiki Barat,Kelurahan Bumi Harapan, Kota Parepare, Provinsi Sulawesi Selatan. Kegiatan ini melibatkan siswa SMP kelas IX.1. Hasil survei menunjukkan bahwa melalui penggunaan video pembelajaran berbasis YouTube dan WhatsApp, sebagian besar siswa dapat memahami materi dengan baik. Dengan video pembelajaran, siswa juga termotivasi untuk belajar. Selain itu, belajar juga menjadi menyenangkan dan menarik. Sehingga, video pembelajaran dapat menjadi alternatif dalam mengatasi kesulitan belajar siswa di tengah pandemi Covid-19. Video pembelajaran tersebut dapat membantu guru menyampaikan pelajaran dengan baik dan jelas. Sehingga, siswa lebih mudah memahami pelajaran karena adanya penjelasan dari guru yang mereka lihat melalui video pembelajaran. Dengan demikian, dapat disimpulkan bahwa video pembelajaran berbasis YouTube dan WhatsApp dapat dijadikan sebagai sumber belajar bagi siswa dan sebagai inovasi pembelajaran bagi guru.
Combination of Digital Image Processing and Statistical Data Segmentation to Enhance SPR and SPRi Sensor-responses
Authors: de Aguiar Gleice M. , de Souza Leandro C. , de Souza Daniel F. L. , Oliveira Leiva Casemiro
Published: November 2021

The work reports the combination of basics digital image processing (DIP) techniques and statistical segmentation strategy (SDS) to improve surface plasmon resonance curve (SPRc) and SPR imaging (SPRi) sensors' performance. The SPR image is used for sensing and monitoring biological events in the so-called SPR imaging process. In the traditional SPR process based on the attenuated total reflection (ATR) method, the image is used to create the SPR curve, and the curve features tracking is employed on sensing applications. The SPR curve features are enhanced after the pixels of the SPR image have been processed with lowcomplexity filters in the spatial domain (brightness, contrast, threshold, and morphological). The bootstrap was used as a statistical processing approach, selecting lines and columns from the image that was less affected by imperfections and noises in the image detector, and consequently reducing the SPR sensor instrumentation disturbances. Experimental tests with reversible binding water-mixture were performed, and both image and statistical processing were reported. The combination of DIP and SDS approaches improves the extraction of the curve features, increasing the performance in terms of resonance position sensitivity until 81%.
Taxonomic and Functional Metagenomics Profiling of Tuwa and Unnai Hot Springs Microbial Communities
Authors: Vora Disha , Shekh Satyamitra , Joshi Madhvi , Patel Amrutlal , Joshi Chaitanya
Published: November 2021

Hot springs are of great importance due to their unique physicochemical properties. Due to unique selection pressure in this habitat, a diverse microbial community is prevailing and can be analyzed by high throughput sequencing technology. Present study focuses on metagenomic sequencing of two hot springs from Gujarat, India namely Tuwa and Unnai through both, culturable and culture independent approach. Sequence analysis from both the water reservoirs depicted higher species richness and diversity based on various diversity indices. The microbial community structure at both the hot springs was distinct and dependent on physicochemical factors like temperature, pH, mineral content etc. Enrichment by cultivation before metagenome sequencing revealed the abundance of Firmicutes (up to 96%) representing cultivable organisms in hotsprings. The bacterial phyla Firmicutes, Proteobacteria, Bacteroidetes, Thermotogae, Deinococcus-Thermus, and Chloroflexi dominate the thermoalkaline spring at Unnai and Tuwa in different proportion. Economically important microorganisms belonging to genera Thermus, Brevibacillus, Anoxybacillus, Bacillus, Pseudomonas, and Geobacillus were prevalent in hot springs. The analysis of functional potential by KEGG revealed pathways for metabolism of carbohydrates, amino acids, vitamins, cofactors and xenobiotics. Annotation with Carbohydrate Active EnZymes (CAZy) revealed the presence of four major classes of enzymes: glycosyl transferase, glycoside hydrolase, polysaccharide lyase and carbohydrate-binding modules. The study provides insight into the microbial community structure and their untapped functional potential for various biotechnological and environmental applications.
A Practical Manner To GTR Recycling in Waste HDPE/ABS
Authors: Varga Csilla , Heller Balázs , Simon-Stőger Lilla , Makó Éva
Published: November 2021

Waste high-density polyethylene (w-HDPE)/ acrylonitrile-butadiene-styrene (ABS)/ground tire rubber (GTR) have been melt blended by two-roll milling. Ternary blends of w-HDPE/ABS/GTR have been observed to be incompatible in the composition range studied which revealed in the deteriorated mechanical properties. Two main types of compatibilizers such as an olefin-maleic anhydride copolymer based one synthesized by the authors and a commercial maleic anhydride grafted polypropylene (MA-g-PP) have been chosen for enhancing compatibility between the components ergo the mechanical properties. For characterizing tensile and impact properties of the blends mechanical tests have been carried out besides the scanning electron microscopy (SEM), X-ray diffraction and Fourier transform infrared spectroscopy. The most advantageous result in industrial practice can be that the experimental additive allows to apply higher GTR concentration ergo gives the opportunity to recycle higher level of GTR.
CD73 Downregulation by EGFR-Targeted Liposomal CD73 siRNA Potentiates Antitumor Effect of Liposomal Doxorubicin (Doxil) in 4T1 Tumor-Bearing Mice
Authors: Soleimani Anvar , Mirzavi Farshad , sahlabadi Sara Nikoofal , Nikpoor Amin reza , Taghizadeh Bita , Barati Mehdi , Soukhtanloo Mohammad , Jafari Mahmoudreza
Published: November 2021

Background

Blocking CD73 ectonucleotidase has been proposed as a potential therapeutic approach for cancer treatment. The purpose of the present study was to investigate the antitumor effect of a novel EGFR-Targeted liposomal CD73 siRNA formulation in combination therapy with Doxil in the 4T1 mouse model.
Methods

CD73 siRNA was encapsulated into nanoliposomes by the ethanol injection method. After preparation, characterization, morphology, and stability evaluation of formulations, the toxicity was measured by MTT assay. Uptake assay and efficiency of the liposomal formulations were investigated on the 4T1 cell line. The liposomal formulation containing CD73 siRNA was targeted with GE11 peptide for in vivo evaluations. Antitumor activity of prepared formulations in combination with Doxil was studied in mice bearing 4T1 metastatic breast cancer cells. Finally, the antitumor efficacy of the formulation in concomitant treatment with Doxil was evaluated in a mouse model of breast cancer.
Results

The size of prepared liposomal formulations at N/P=16 for the liposomal CD73 siRNA and GE11-lipo CD73 siRNA groups were 89 nm ± 4.4 and 95 nm ± 6.6, respectively. The nanoparticle’s PDI was less than 0.3 and their surface charge was below 10 mV. The results demonstrated that N/P=16 yielded the best encapsulation efficiency which was 94% ± 3. 3. AFM results showed that the liposomes were spherical in shape and were less than 100 nm in size. The results of the MTT assay showed significant toxicity of the liposomes containing CD73 siRNA during the 48-hour cell culture. Real-time PCR and flow cytometry results showed that liposomes containing CD73 siRNA could effectively downregulate CD73 expression. Liposomal formulations were able to significantly downregulate CD73 gene expression, in vivo. However, CD73 downregulation efficiency was significantly higher for targeted form in comparison with non-targeted formulation (P-value <0.01). The combination showed maximum tumor growth delay with remarkable survival improvement compared to the control group. Studying the immune responses in the treatment groups which received doxorubicin, showed decreased number of lymphocytes in the tumor environment. However, this decrease was lower in the combination therapy group. Finally, our results clearly showed that CD73 downregulation increases the activity of CD8+ lymphocytes (INF-ℽ production) and also significantly decreases the Foxp3 in the CD25+ lymphocytes compared to the control group.
Conclusion

GE11-Lipo CD73 siRNA formulation can efficiently knock down CD73 ectonucleotidase. Also, the efficacy of Doxil is significantly enhanced via the downregulation of CD73 ectonucleotidase.
Retrospective Study of FinDer Algorithm During the 2019, Ridgecrest Earthquake Sequence
Authors: Huang Wei
Published: November 2021

Real-time characterization of evolving rupture is crucial for mitigating against seismic hazards exposed to potentially devastating earthquake events in EEWs (Earthquake Early Warning system). Currently, FinDer (Finite Fault Rupture Detector) algorithm explicitly utilizes observed ground motion pattern to solve for the evolving rupture to generate alerts for early warning purpose, which is currently contributing to ShakeAlert EEW system in West Coast of United States, within the area covered by the Advanced National Seismic System (ANSS) network. Here we implement FinDer offline to explore its feasibility assuming ideal field telemetry on a database of real earthquakes with magnitude M ≥5.0 occurring in Ridgecrest, Southern California in 2019. We specially focus on evaluating the performance of FinDer through end-user-orientated analysis in terms of warning time and accuracy of ground shaking prediction. Overall, FinDer classifies alerts with a rate of success over 74% across a broad range of alert criteria, substantial fraction of sites can be successfully alerted including the most difficult cases with high ground motion intensities regardless of invariable few seconds of warning time. FinDer can be configured to generate more useful alerts with higher cost savings by applying lower alert threshold during the Ridgecrest earthquake sequence. Furthermore, although large fractions of sites would have been timely alerted, it is significantly challenging for predicting accurately the moderate or worse intensities (Modified Mercalli Intensity > 5.5) in advance even if applying lower alert threshold and higher damage threshold. Nonetheless, FinDer performs well in an evolutionary manner to guarantee reliable alerts by resorting to a consistent description of point source or occurring rupture.
Synergistic Lethality Effects of ABT-199 and Apatinib on DLBCL: Antitumor Efficacy and Underlying Mechanisms
Authors: Shi Yuanfei , Ye Jing , Shen Huafei , Xu Yi , Wan Rui , Ye Xiujin , Jin Jie , Xie Wanzhuo
Published: November 2021

Background

To investigate the effect of ABT-199 combined with Apatinib on diffuse large B-cell lymphoma (DLBCL).
Methods

We explored the synergistic effect of ABT-199 and Apatinib in diffuse large B-cell lymphoma (DLBCL) cell lines, DLBCL patient samples, and DLBCL mouse models, using viability assay and immunoblotting. RNA sequencing assay helped identify mechanisms of ABT-199 plus Apatinib.
Results

ABT-199 combined with Apatinib inhibited cell proliferation, reduced colony-forming capacity, and induced apoptosis and cell cycle arrest in DLBCL cells. Mechanistically, the combination therapy inhibited tumor cell growth and promoted tumor cell death by regulating EDN1 and MAPK related pathways and activating the intrinsic apoptotic pathway. The effect of the combination therapy was also validated in primary DLBCL blasts and xenograft mouse models.
Conclusion

Our findings indicate that simultaneously targeting both BCL-2 and VEGFR2 might serve as a promising therapeutic strategy for DLBCL.
Seasonal Dynamics of Agro-meteorological Drought in Mberengwa and Zvishavane Districts between 2017 and 2020, Zimbabwe
Authors: Mupepi Oshneck , Matsa Mark M
Published: November 2021

Drought severity is increasing in Southern Africa which is affecting rain-fed agriculture, the main source of livelihood in most countries in this region. The study assessed the seasonal spatio-temporal dynamics of agro-meteorological drought between 2017 and 2020 in Mberengwa and Zvishavane Districts. An empirical research design supported by quantitative geographical information system and remote sensing techniques was adopted in this study. Microsoft excel 2013, SPI generator and ArcMap 10.5 software were used for data analysis in this study. Results showed that both Mberengwa and Zvishavane Districts experienced an increasing trend in spatial coverage of drought from 2017 to 2019 before a slight decline in 2020. From 2017, drought severity increased in terms of spatial coverage with this spatial distribution increasing to almost over ¾ of the wards in both Mberengwa and Zvishavane Districts between 2018 and 2020. Since 2017, on a ward level basis, both districts have been experiencing late onset and early cessation of the rain season as shown by increasingly dry October, November and March, months which determine the length of crop growing season in these two districts. Results indicated that the month of March was drier in Mberengwa whilst the month of December was drier in Zvishavane, an indication of more mid-season dry spells in Zvishavane and earlier rainfall cessation in Mberengwa. Drought is worsening in both Mberengwa and Zvishavane Districts hence long term drought resilience interventions are required to improve drought resilience of communities in these areas. The study recommends the Government of Zimbabwe and other stakeholders of drought resilience building like CARE International, World Vision among others to prioritize launching of resilience building initiatives in most vulnerable areas whilst guided by fine empirical information on spatial distribution of drought.
Identification of an SRY-Negative 46,XX Infertility Male with a Heterozygous Deletion Downstream of SOX3 Gene
Authors: Qin Shengfang , Wang Xueyan , Wang Jin
Published: November 2021

Background: A male individual with a non-chimeric karyotype of 46,XX is very rare. We explored the genetic aetiology of an infertility male with 46,XX and SRY negative.Methods: The peripheral blood sample was collected from the patient and subjected to a range of genetic testing, including conventional chromosomal karyotyping, short tandem repeat (STR) analysis for chromosome 13, 18, 21, X, Y contained SRY gene, azoospermia factor (AZF) deletion analysis including SRY gene, fluorescence in situ hybridization (FISH) with specific probes for CSP X/CSP Y/SRY, chromosomal microarray analysis (CMA) for genomic copy number variations (CNVs), and whole-genome analysis(WGA) for SNV&InDel variants, and the X chromosome inactivation (XCI) analysis for AR gene.Results: The patient was found to have a 46,XX karyotype. Neither AZFa+b+c nor SRY band was detected in the electrophoresis result. FISH results of both interphase cells with CSPX/CSPY probe and metaphase cells with CSPX/CSPY/SRY probe showed two green fluorescence signals at the centromeres of X chromosomes, but no Y chromosome and SRY fluorescence signal. QF-PCR results showed that the patient had only the AMELX fluorescence peak of the X chromosome but no AMELY and SRY fluorescence peak. All results of the Karyotype, FISH, and STR did not suggest limited Y chimerism. CMA showed he had a heterozygous deletion of about 867 kb in Xq27.1 (hg19: chrX: 138,612,879-139,480,163 bp), located at 104 kb downstream of SOX3 gene, including F9, CXorf66, MCF2 and ATP11C; Meanwhile, whole-genome sequencing also found no SNV&InDel mutation associated with abnormal sex development. 75% X chromosome inactivation was detected.Conclusions: Although the pathogenicity of 46,XX male patients with SRY negative remains unclear, SOX3 expression of the acquired function may be associated with partial testis differentiation. Therefore, copy number variation of SOX3 gene and regulatory region should be performed routinely for these patients.
A Multilevel Systemic Pan-cancer Analysis: Collagen Triple Helix Repeat Containing-1 is a Potential Target for Tumor Immunotherapy
Authors: Zhang Jiangtao , Wu Xianghua , Ruan Huichao , Wang Changli , Yang Rong qiang , Fu xiaobing
Published: November 2021

Background: Cancer is one of the leading causes of pathological death in humans. Although CTHRC1 is a prooncogene highly expressed in a variety of tumor tissues, the specific biological mechanisms of CTHRC1 involvement in cancer development need to be elucidated. Methods: In the present study, nine online bioinformatics databases were employed to explore the potential prognostic and grading value of CTHRC1 in generalized cancer as well as its potential role in regulating tumor immunity. Results: Data from GEPIA2.0, Oncomine, TNMplot, Kaplan-Meier Plotter and TISIDB database had consistently demonstrated that CTHRC1 was associated with the expression, prognosis and typing in most cancer tissues. Cbioportal and SMART analysis revealed that genomic changes and methylation of CTHRC1 in most tumor tissues. Finally, Sangerbox and TIMER database analysis suggested that CTHRC1 was involved in the changes of immune cell components in tumor immune microenvironment, with certain heterogeneity. Meanwhile, CTHRC1 was correlated with TMB, MSI, neoantigen and tumor immune checkpoint, especially CD276. Conclusion: CTHRC1 had the potential as a prognostic and grading molecular marker for pan-cancer. And CTHRC1-related targeting agents may be a novel breakthrough in tumor immunotherapy.
Influence of Bentonite Nanoparticles on Properties of PVP-CMC-Gums Biodegradable Hydrogel Films for Biomedical Applications
Authors: Idris Samahir Sheikh , yucel ozgun
Published: November 2021

Using polymer daily becomes increasingly extensive; the many characteristics of hydrogel lead to a wide range of uses, particularly in biomedical applications. Hydrogel films were made from a variety of materials in this investigation. Casting techniques and room temperature drying were used to make PVP- CMC- Gums films based on hydrogels, however, the effects of adding bentonite clay were needed. SEM, FTIR, XRD, TGA, swelling, solubility, contact angle, and a variety of other studies were used to illustrate and analyze a variety of physical, mechanical, thermal, and many characteristics. The major findings revealed new peaks, which indicate the creation of cross-linking bonds, which are the primary cause of capsulation and release characteristics, indicating that these films might be utilized in drug delivery and a variety of other applications. The PCXB film has the best color, surface hydrophobicity, solubility, and swelling properties, while the PCGB film has the greatest biodegradability and permeability results, and both films have strong thermal, mechanical, and releasing properties. As a result, adding bentonite clay to hydrogel films improves all of their characteristics, making them suitable for a variety of biomedical applications such as dentistry root filling, tissue engineering, contact lenses, and bandages.
Assessing Negative Core Beliefs in Eating Disorders: Revision of the Eating Disorder Core Beliefs Questionnaire
Authors: Hatoum Amaani H. , Burton Amy L , Abbott Maree J
Published: November 2021

Background: Increased theoretical and empirical attention has been given to examining the role of core beliefs in both the development and maintenance of eating disorders (EDs). The Eating Disorder Core Beliefs Questionnaire (ED-CBQ) is self-report measure designed to assess five dimensions of core beliefs relating to eating disorders; self-loathing, unassertive/inhibited, demanding/needing help and support, abandoned/deprived, and high standards for the self. The present study aimed to evaluate the psychometric properties of the ED-CBQ and to develop a revised and improved version of the original measure, as necessary, after evaluating its factor structure and related properties.Methods: A sample of undergraduate university students (N = 763) completed an online test battery of questionnaires. Putative ED (n = 384) and non-ED (n = 379) subgroups were created from self-reported responses from the Eating Disorder Examination Questionnaire (EDEQ). Confirmatory factor analyses (CFAs) were performed, and internal consistency, construct validity, group differences and clinical utility was examined. Results: An initial CFA did not support the original five-factor 40-item ED-CBQ. Two revised versions were developed that both possessed equal or superior psychometric properties to the original 40-item measure. The ED-CBQ-SF and ED-CBQ-R both demonstrated superior model fit, similar levels of reliability and construct validity, and the ability to discriminate between putative ED diagnostic groups.Conclusions: Our results suggest that the ED-CBQ-SF and ED-CBQ-R are both valid, reliable, but more importantly efficient and accessible measures with the potential to be utilised both clinically and in research settings.