bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on Key Influencing Factors of Ecological Environment Quality in Barcelona Metropolitan Region Based on Remote Sensing
Authors: Zhang Xu , Ramos Blanca Arellano , Cladera Josep Roca
Published: November 2024

With the rapid development of urbanization, the ecological environment is being destroyed. Taking Barcelona Metropolitan Region as an example, this paper established an ecological environment quality assessment system suitable for different time and region based on remote sensing to evaluate it from 2006 to 2018. And built various OLS models to analyze multiple variables affecting the ecological environment. Finally, the characteristic triangular space structure was used to explain the interaction between the two key variables. The results showed that the ecological quality was unevenly distributed. The largest green space contributed the most ecological benefits, but its area was decreasing and its shape was more fragmented. NDVI was the most significant natural variable related to the distribution of green space. Precipitation was the most closely related climate factor to NDVI. And there was a complex two-way interaction mechanism between the two, and its boundary value was getting higher and higher. In conclusion: The environmental quality of BMR needs to be improved. There is a two-way relationship between the two key factors. The characteristic triangle can successfully explain the interaction mechanism between precipitation and NDVI.
Transfusion Requirements for Severe Anemia in Acute Cardiovascular Patients—A Single Center Retrospective Study in Constanta County Cardiology Department
Authors: Ali Sevigean , Badea Iulia Andreea , Botnarciuc Mihaela , Tuta Liliana-Ana , Daba Lavinia Carmen , Alexandru Andreea , Parepa Raluca Irinel , Stanigut Alina- Mihaela , Ionescu Mihaela
Published: November 2024

Anemia is common in hospitalized cardiac patients and affects prognosis. Even moderate levels of anemia can be associated with high cardiovascular mortality when compared to normal hemoglobin levels in cases of patients with acute decompensated heart failure. Background: Anemia is a comorbidity potentially treatable, with significant prognostic implications. A restrictive transfusion is triggered by hemoglobin is ≤8g/dl (severe anemia) and a liberal transfusion is considered when hemoglobin ≤10 g/dL. Methods: We perform a retrospective analysis of the patients hospitalized in the Cardiology Department of Constanta County Hospital who required blood derivatives transfusions, between 1st of January 2021 - 31st of December 2021. Results: Out of the total 270 patients, 170 received a single unit of resuspended erythrocyte concentrate within the same month, while 100 required multiple transfusions, receiving between 2 and 5 units during a single hospitalization to correct anemia. Before transfusions, the mean hemoglobin (Hb) level was 7.60 g/dl, with values ranging from 6.50 g/dl to 9.10 g/dl. Men show a higher prevalence (64%) than women (36%), likely due to gender differences in susceptibility to heart conditions. After transfusions, the mean Hb reached 10.05 g/dl (minimum/maximum values of 7.40 and 12.70 g/dl). CKD patients consistently experience higher in-hospital mortality across LVEF sub-groups, while CRS patients have relatively lower mortality rates, with significant associations observed between reduced LVEF and increased mortality across all patient groups. Conclusions: Anemia in heart failure patients is linked to worsening symptoms, including decreased exercise tolerance, increased cardiovascular events, decreased kidney function and higher hospitalization and mortality rates, especially in those with associated acute or chronic kidney failure. The findings aim to inform and optimize clinical decision making, particularly regarding transfusion strategies and risk management in this high-risk population.
Copper Anode Slime Processing with a Focus on Gold Recovery: A Review of Traditional and Recent Technologies
Authors: Moosavi-Khoonsari Elmira , Tripathi Nagendra
Published: November 2024

Copper anode slime (CAS) contains high concentrations of precious metals, particularly gold, which can reach up to 11 wt%. During copper anode electrorefining, 5-10 kg of CAS is generated per ton of copper cathode. Processing CAS is crucial for economic reasons, as gold significantly contributes to revenue for both miners and custom copper smelters. This paper provides a comprehensive review of industrial processes and technologies for CAS treatment, with a focus on gold recovery. It documents traditional and recent trends and analyzes the advantages and disadvantages of existing methods. Key factors affecting revenue, such as gold production lead time, in-process inventory, and first-pass recovery rate, are discussed to mitigate losses in fluctuating gold markets. CAS processing routes are categorized into two main groups: traditional hybrid routes (involving hydrometallurgy, pyrometallurgy, and electrorefining/electrowinning) and rather recent purely hydrometallurgical routes. Traditional methods can take up to 45 days, with gold recovery occurring late in the process and losses arising in anode, cathode, electrolyte, or slag. In contrast, purely hydrometallurgical routes have total processing times of 7-8 days, achieve early gold recovery, and can attain first-pass recovery rates as high as 99%. These findings indicate that purely hydrometallurgical routes outperform traditional hybrid methods. This paper aims to serve as a guideline for industrial CAS processing, assisting custom copper smelters in navigating challenging market conditions marked by low treatment and refining charges, with an emphasis on enhancing gold recovery to promote sustainability.
Sensor Fusion for Real‐Time Object Detection and Spatial Positioning in Unmanned Vehicles Using YOLOv8 and ESP32‐Cam
Authors: Aniobi Anthony
Published: November 2024

With the rise of autonomous systems, the need for precision in navigating uncertain environments has become paramount. Unmanned vehicles in particular require accurate detection and spatial positioning of obstacles to ensure safe and efficient navigation. This research introduces a sensor-fusion based system that integrates an ESP-32 camera module and an ultrasonic sensor to detect objects and calculate their relative position to the vehicle in an average of 715 milliseconds. The object detection pipeline utilizes the Yolov8 object detection algorithm to detect and classify objects in the camera’s field of view. Combining the pinhole camera formula and Yolov8 bounding box, an equation is formulated to compute the exact spatial coordinates of the object. The system was validated through a series of experiments involving different object types at varying distances, resulting in a dataset of 397 instances with a total of 3176 values. The solution achieved a spatial detection accuracy of 89%, demonstrating its potential for reliable obstacle avoidance in unmanned vehicles.
A Parametric Six-Step Method For Second Order IVPs With Oscillating Solutions
Authors: Papadopoulos Dimitris F.
Published: November 2024

In this paper, we have developed an explicit symmetric six-step method. This new method is phase-fitted and incorporates a free coefficient as a parameter. Using a wide range of values for this parameter, we computationally define the periodicity interval. Numerical outcomes guided us toward identifying optimal values for the parameter, establishing the new method’s high efficiency. The efficiency of the new method is demonstrated through its application to oscillatory problems, comparing it with well-known phase-fitted methods.
The Neuroimmunology of Autism
Authors: Varia Jeet , Herbert Martha , Hooker Brian
Published: November 2024

Alterations and maladaptation of the immune system remain some of the most controversial concepts in autism spectrum disorder (ASD). Nonetheless, intensifying evidence confirms that much of what ASD involves is related not to fixed “autistic states of being” but rather to the consequences of environmental insult and complex psychological and physiological processes along a neuro-immune-microbiota-axis. Beginning with an epidemiological and etiological underpinning, followed by biochemical and psychiatric standpoints, we elaborate on the current role of the immune system in the pathophysiology of ASD. Finally, taking a neuroimmunological perspective, we highlight the need for a multi-scale, holistic, and “middle-out” approach to understanding and developing future therapeutic modalities to address the core symptoms of ASD that go beyond the current reductionist and “magic-bullet” medical paradigm.
Analysis of Outdoor and Indoor Radon Concentration Time Series Recorded with RadonEye Monitors
Authors: Bossew Peter , Benà Eleonora , Chambers Scott , Janik Miroslaw
Published: November 2024

Consumer-grade economical radon monitors are becoming increasingly popular in private and institutional use, both in the context of Citizen Science and traditional research. Although originally designed for screening indoor radon levels in view of radon regulation and decisions about mitigation or remediation - motivated by the health hazard posed by high radon concentrations - researchers are increasingly exploring their potential in some environmental studies. For long time, radon has been used as a tracer for investigating atmospheric transport processes. This paper focuses on the RadonEye, currently the most sensitive among low-cost monitors available on the market, and specifically, its potential use for monitoring very low radon concentrations. It has two objectives: firstly, discussing issues of statistics of low count rates and secondly, analyzing radon concentration time series acquired with RadonEyes outdoors and in low-radon indoor spaces. Regarding the first objective, among other things, the inference of reported to expected true radon concentration is discussed. The second objective includes the application of autoregressive methods and fractal statistics to time series analysis. The overall result is that radon dynamics can be well captured using this "low-tech" approach. Statistical results are plausible; however, few results are available in the literature for comparison, particularly concerning fractal methods. The paper may therefore be seen as an incentive for further research in this direction.
Analyzing the Accuracy of Satellite Derived DEMs Using High-Resolution Terrestrial LIDAR
Authors: Mohamed Aya Hamed , Keskes Mohamed Islam , Nita Mihai Daniel
Published: November 2024

Accurate estimation of Digital Elevation Models (DEMs) derived from satellite data is critical for numerous environmental applications. This study evaluates the accuracy and reliability of two satellite-derived elevation models, ALOS World 3D and SRTM DEMs, specifically for their application in hydrological modeling. A comparative analysis with Terrestrial Laser Scanning (TLS) measurements assessed the agreement between these datasets. Results indicate significant correlations between satellite DEMs and TLS measurements, with adjusted R-square values of 0.8478 for ALOS and 0.955 for SRTM. To quantify the average difference, root mean square er-ror (RMSE) values were calculated as 10.43 m for ALOS and 5.65 m for SRTM. Additionally, slope and analyses highlighted terrain characteristics across DEMs. Slope analysis revealed a strong negative correlation between SRTM and TLS slopes (p < 4.47e-10), while no significant correlation was found between ALOS and TLS slopes. Aspect analysis showed significant posi-tive correlations for both ALOS and SRTM with TLS aspect, capturing 30.21% of the variance. These findings demonstrate the accuracy of satellite-derived elevation models in representing terrain features relative to high-resolution terrestrial data.
Etiological Connections Between Initial COVID-19 and Two Rare Infectious Diseases
Authors: Zhang Zhengjun
Published: November 2024

The origin of COVID-19 remains unclear despite extensive research. Theoretical models can simplify complex epigenetic landscapes by reducing vast methylation sites into manageable sets, revealing fundamental pathogen interactions that leap medical advances for the first time in tracing virus origin in the literature and practices. In our study, a max-logistic intelligence classifier analyzed 865,859 Infinium MethylationEPIC sites (CpGs), identifying eight CpGs that achieved 100% accuracy in distinguishing COVID-19 patients from other respiratory disease patients and healthy controls. One CpG, cg07126281, linked to the SAMM50 gene, shares genetic ties with rare infectious diseases like Sennetsu fever and glanders, suggesting a potential connection between COVID-19 and these diseases, possibly transmitted through contaminated seafood or glanders-infected individuals. Identifying such links among 865,859 CpG sites is challenging, with a random correlation probability of less than one in ten million. However, the likelihood of finding meaningful associations with rare diseases lowers this probability to one in one hundred million, reinforcing the credibility of our findings. These results highlight the importance of investigating seafood markets and global supply chains in tracing COVID-19's origins and emphasize the need for ongoing biosafety and biosecurity measures to prevent future outbreaks.
Connectivity Reliability and Approachability Indicators in Public Transport
Authors: Bhouri Neila , Campisi Tiziana , Aron Maurice , Moghaddam S. M. Hassan Mahdavi
Published: November 2024

The connectivity reliability of public transport depends on a number of factors, including public transport routes, the connections between them, their frequency, their availability, and the availability of public transport and infrastructure. A shortest path algorithm is used to find up to "k" paths connecting each Origin-Destination pair in space-time, taking into account the schedules and a constraint on the maximum tolerable waiting time. For each path, four reliability indicators are proposed, as well as an approachability indicator, related to the level of transport supply. Thanks to two sets of equations, these indicators are also computed on the origin-destination and network levels. This enables fleet managers to evaluate and compare strategies for improving the connectivity reliability and the transport supply, such as increasing the number of public transport routes, reducing route length or increasing frequency. From an application on the bus network of a city in Brittany in France, we show how to understand and use these indicators.
Gluten-Free Diet Adherence Evaluation in Adults with Long-Standing Celiac Disease
Authors: Kowalski Marek , Domżał-Magrowska Danuta , Szcześniak Piotr , Bulska Magdalena , Orszulak-Michalak Daria , Małecka-Wojciesko Ewa
Published: November 2024

Background: Celiac disease is an autoimmune disease that results from the interaction of genetic, immune and environmental factors. According to 2020 ESPGHAN guidelines, an elimination diet (i.e. excluding products that may contain gluten) is the basic method of treating celiac disease. Following a gluten-free diet is extremely problematic and patients often make unconscious deviations from the diet. Objective: The aim of the study was to asses the frequency of conscious diet mistakes and unconscious deviations from the gluten-free diet in a group of patients with long-standing celiac disease and their impact on the frequency of typical and atypical symptoms. Methods: The study included 38 patients, 30 women and 8 men with a verified diagnosis of celiac disease. The effectiveness of the gluten-free diet was assessed in all participants. Blood was collected to determine IgA anti tissue transglutaminase II antibodies and IgG antibodies against deamidated gliadin peptides by ELISA. All survey participants provided data concerning current gastrointestinal and systemic symptoms, bowel habits, comorbidities, dietary habits, physical activity and socioeconomic conditions. Results: 25 patients (65.78%) declared strict adherence to the gluten-free diet. However, in this group, 7 (18.4%) patients had significantly increased levels of anti-tTG antibodies (mean 82.3 RU/ml ±78.9 SD at N<20 RU/ml). Among the patients who consciously made diet mistakes, 6 (46.2%) demonstrated increased levels of anti-tTG antibodies. The analysis did not reveal any difference between the frequency of intestinal and extraintestinal symptoms in patients making diet mistakes and following the gluten-free diet. Conclusions: More than half of celiac patients unconsciously or consciously make diet mistakes, which indicates an urgent need to increase their education about the diet. Regardless of whether the gluten-free diet is followed, both typical and atypical symptoms of the disease have been observed among celiac patients.
Differential Effects by Positive and Negative Types of Empathy on Depression and Anxiety: Gender Differences in Spanish Emerging Adults
Authors: Gomez-Baya Diego , Manrique-Millones Denisse , Garcia Arlen J. , Lopez-Bermudez Esther
Published: November 2024

(1) Background: Literature to date has shown some contradictory findings regarding the associations between empathy and mental health. Thus, the Caring component of Positive Youth Development has been related to more mental health symptoms, while positive empathy seems to have a positive impact on psychological adjustment. The present study aimed to analyze the associations between Caring and positive empathy with youth depression and anxiety, as well as examining gender differences. (2) Methods: A cross-sectional study was carried out by administering an online self-report to a sample composed of 370 university students (67.2% women), aged 18-29 (M=21.29, SD = 3.61), enrolled across 10 universities in the Spanish region of Andalusia; (3) Results: Women reported higher levels of the caring dimension of PYD, more positive empathy, but more symptoms of depression and anxiety. Mediational analyses to explain the gender differences in mental health concluded that: a) women reported more depression and anxiety partly due to their higher scores in Caring, and b) despite women had more positive empathy than men, this mechanism was only protective against anxiety in the subsample of men; (4) Conclusions: The promotion of mental health in university context should include fostering adaptive empathetic skills.
Aged Garlic Extract (AGE) and Its Constituents S‐allyl‐cysteine (SAC) Inhibit the Expression of Pro‐Inflammatory Genes Induced in Bronchial Epithelial IB3‐1 Cells by Exposure to the SARS‐CoV‐2 Spike Protein and the BNT162b2 Vaccine
Authors: Gasparello Jessica , Papi Chiara , Marzaro Giovanni , Macone Alberto , Zurlo Matteo , Finotti Alessia , Agostinelli Enzo , Gambari Roberto
Published: November 2024

Garlic (Allium sativum L.) is a species of the onion family, Alliaceae that has been widely used as a food and a folk medicine. The objective of this study was to determine the effects of AGE (Aged garlic extract) on proinflammatory genes relevant to COVID-19. To this aim, we treated bronchial epithelial IB3-1 cells with SARS-CoV-2 Spike protein (S-protein) or with the COVID-19 BNT162b2 vaccine in the absence or in the presence of AGE. The results obtained demonstrated that AGE is a potent inhibitor of the S-protein in-duced expression of the IL-1beta, IL-6 and IL-8 genes. Bio-plex analysis demonstrate that AGE reduced release of IL-6 and IL-8, that were highly induced by S-protein. No inhibition of cells growth, toxicity and proapoptotic effects were found in AGE-treated cells. The effects of one of the major AGE constituents (S-allyl cysteine, SAC) were studied on the same experimental model systems. SAC was able to inhibit the S-protein induced expression of IL-1beta, IL-6 and IL-8 genes and extracellular release of IL-6 and IL-8, con-firming that S-allyl cysteine is one of the constituents of AGE that are responsible for inhibiting S-protein induced pro-inflammatory genes. Docking experiments suggest that a possible mechanism of action of SAC is an interference with the activity of Toll-like receptors (TLRs), particularly TLR4, thereby inhibiting NF-B and NF-B regulated genes, such as IL-1beta, IL-6 and IL-8 genes. These results suggest that both AGE and SAC deserve further experimental efforts to verify their effects on pro-inflammatory genes in SARS-CoV-2 infected cells.
Analysis of Dose-Response and Analgesic Specificity of Locally Administered Morphine in the Carrageenan-Induced Inflammatory Model
Authors: Jafal Nader Mugurel , Stoleru Smaranda , Zugravu Aurelian , Orban Carmen , Popescu Mihai , Dumitrascu Oana Clementina , Poenaru Elena , Jafal Alexandra Mihaela , Fulga Ion
Published: November 2024

Background/Objectives: This study investigates the role of peripheral opioid receptors in modulating pain outside the central nervous system. Methods: The first experiment aimed to establish a dose-effect relationship for intraplantar morphine administration in a rat model of carrageenan-induced inflammation by testing successive doses after the carrageenan injection. Additionally, the second experiment assessed whether a 5 mg/kg dose of morphine has central nervous system effects by comparing its effects with 5 mg/kg and 10 mg/kg doses given intraperitoneally. Results: In the first part we observed that lower doses (2.5 mg/kg) did not significantly affect paw withdrawal latency after thermal stimulation, while higher doses (5 mg/kg and 10 mg/kg) resulted in significant increases, suggesting that maximum receptor activation occurs at 5 mg/kg. However, the 20 mg/kg dose exhibited central nervous system effects, indicating systemic absorption. The second part compared intraplantarly and intraperitoneally administered morphine, finding that while the intraplantar 5 mg/kg dose provided a significant analgesic effect, the same dose given intraperitoneally did not produce similar results, reinforcing the hypothesis that local administration targets peripheral receptors. Conclusions: Overall, the findings indicate that morphine's analgesic effect at lower doses is primarily mediated by peripheral opioid receptors, with systemic effects becoming evident at higher doses. This study aligns with existing literature emphasizing the potential for peripheral opioid receptor activation to alleviate inflammatory pain with minimized central effects
PROSPECTS OF ECONOMIC INTEGRATION OF UKRAINE WITHIN THE FRAMEWORK OF THE ASSOCIATION AGREEMENT WITH THE EU
Authors: Posokhov Ihor , Ovcharenko Andrii , Husarova Darya
Published: November 2024

The article examines the prospects of economic integration within the framework of the association agreement with the EU. It is noted that modern studies on the integration of Ukraine into the EU most often consider the problems of the Ukrainian dimension of European and Euro-Atlantic integration, Ukraine's acquisition of the status of a candidate for EU membership in the conditions of the war in Ukraine , the state European integration policy of Ukraine: theory, methodology, mechanisms, reengineering in international business. The main prospects for further economic integration of Ukraine into the EU are offered: strengthen responsibility for corruption schemes in the economy and in the field of intellectual property rights; implement the Tax Policy Strategy, which should take into account all sectoral aspects of the Association Agreement with the EU; strengthen control over public procurement; apply real tools to stimulate energy efficiency and innovative development (tax credit or tax discount), environmentally safe production (emission limits, correction factors, etc.), establish a tax-free minimum income of citizens and apply real control over persons receiving tax benefits. It is justified that the level of innovative activity should be stimulated primarily by tax benefits. It is shown that in foreign countries, the emphasis is primarily on the financing of innovative research by private companies, which allows them to obtain an innovative product, which can then be sold both inside the country and outside its borders. In Ukraine, for the most part, the state is not interested in such processes and does not create certain preferences for persons developing innovative products. It is proposed to introduce an innovative tax credit, which will allow subjects of innovative activity to reduce the tax burden from corporate income tax or postpone its payment. Thanks to this approach, Ukraine can obtain innovative products that will be in demand on the world market.
SISTEM PENYIRAMAN OTOMATIS PADA PEMBIBITAN PRE-NURSERY KELAPA SAWIT BERBASIS INTERNET OF THINGS
Authors: Eka Putra Dian , Rosman Edwar , Flomina G Katrina , Hasanah Miftahul , Salam Riyan Ikhbal
Published: November 2024

The application of automation technology in the agricultural sector is a highly effective solution for improving the efficiency and productivity of seedling cultivation, particularly in oil palm nurseries. CV Pangean Raya TBS is an oil palm nursery business located in Solok Selatan Regency. CV Pangean Raya TBS is currently facing challenges in the watering process of oil palm seedlings, as it is still done manually. This manual method leads to wasted time, labor, and water. Manual watering often results in uneven water distribution, which can affect the quality of the oil palm seedlings. This research aims to design and implement an efficient Internet of Things (IoT)-based automatic watering system using a soil moisture sensor, ESP32 module, and RTC. The system is designed to monitor soil moisture conditions in real time and regulate watering automatically. The automatic watering is based on the moisture values detected by the sensor. Watering can also be manually controlled via a smartphone when needed, such as during rainfall, to prevent water wastage and overwatering of the oil palm seedlings. This system can help plantation owners optimize water usage, increase seedling productivity, and reduce dependence on manual labor. The research results indicate that the watering system can operate automatically based on the moisture data received, making it effective in conserving resources, improving productivity, and providing better control over plant conditions.
IMPLEMENTASI CHATBOT YANG TERINTEGRASI LAYANAN KEPOLISIAN DALAM PEMBUATAN SIM
Authors: Allaam Ekananda Naufal , Zuliarso Eri
Published: November 2024

Studi ini menyarankan penggunaan pemrosesan bahasa alami (NLP) untuk mengintegrasikan chatbot dengan layanan kepolisian selama pengiriman izin pengemudi (SIM). Layanan polisi sekarang dapat memberikan informasi kepada publik lebih cepat berkat penggunaan teknologi chatbot, termasuk rencana perjalanan untuk kartu SIM dan instruksi perpanjangan SIM. Studi ini menggunakan metodologi penelitian pengembangan, menggunakan teknik kuantitatif dan kualitatif untuk mengumpulkan data melalui pengamatan, wawancara, dan dokumentasi. Dengan potensi untuk berdampak signifikan pada penggunaan teknologi untuk meningkatkan layanan publik, integrasi chatbot dengan layanan kepolisian dalam proses pengiriman kartu SIM adalah langkah penting menuju peningkatan efektivitas dan aksesibilitas layanan publik.
CIPP-Based Evaluation of the Tahfidz Al-Qur'an Program at SMP Khadijah Surabaya
Authors: Muntafi'ah Umi , Kusaeri Kusaeri
Published: November 2024

This study aims to evaluate the extent to which the tahfidz program at Khadijah Junior High School is planned, how the learning method is implemented effectively, and the impact on its output so that the profile of Khadijah Junior High School graduates can be said to be successful in becoming huffadz. The approach used in this research is a qualitative approach, data collection techniques through observation methods and interviews with the Vice Principal for curriculum, tahfidz teachers and students of SMP Khadijah. The CIPP (Context, Input, Process, Product) evaluation model in the context of this research is to explore the extent of the targets or goals, plans, actions and graduates of the tahfidz program at Khadijah Junior High School. The results of this study prove that; 1) Context evaluation, shows that this program has quality and quantity targets set in the strategic plan of the Khadijah foundation, 2) Input evaluation, Tahfidz program is planned systemically with clear and detailed planning. 3) Process evaluation, tahfidz learning activities are well organized, organized by the division of tahfidz classes tailored to the competence of students' Al-Qur'an reading, 4). Product Evaluation, Khadijah Junior High School graduates exceed the strategic plan target. Challenges that need to be considered in this tahfidz program include motivating students to be interested in participating in the tahfidz program and clarity of memorization targets.
Evaluating Entrepreneurial Intention Among Pesantren Students: Fostering Empowerment Through Education
Authors: Primanto Aji , Puspitasari Linda
Published: November 2024

Traffic education has the potential to reduce accident rates by changing the behavior and attitudes of road users. Through effective outreach and training, road safety messages can be instilled in public awareness, thereby reducing violations of traffic rules and avoiding risky behavior that causes accidents. Additionally, traffic education also helps improve driving skills and situational awareness, which are important factors in reducing accidents. Which can be taught to children at primary and secondary education levels. The research results show that Traffic Education for Elementary School and Middle School Children is one of the important programs carried out to provide children with an understanding of safe and correct traffic procedures. This program aims to provide knowledge and skills to children in dealing with various traffic situations around them. Traffic education for elementary school and MI children is carried out in stages and is adjusted to the child's age and development level. Civics and Religion are subjects that are able to contribute to solutions to the various crises that hit Indonesia, especially multidimensional crises related to Values, Norms, Morals and Traffic Ethics through Education.
Implementation of the Religious Moderation Program to Realizing the Project Student Profile Pancasila and Rahmatan Lil Alamin (P5 and PPRA) in Madrasah
Authors: Burhanuddin Hamam , Imron M.
Published: November 2024

This research will focus on Strengthening the principles of religious moderation in the Islamic education, multicultural values in education and strategies for developing religious moderation to realizing P5 PPRA. The method a qualitative descriptive approach, collecting data with observation, interviews and documentation, the validity of data credibility, transferability, dependability, and certainty. Result The internalization of religious moderation values in realizing the Project to Strengthen the Pancasila Student Profile (P5) and the Rahmatan lil’alamin Student Profile (PPRA) at carried out through co-curricular activities, integration into learning activities, and extracurricular activities focused on three values: nationalism, diversity, and tolerance through transformation, trans internalization, and the transaction of values, The values of religious moderation instilled in students are the values of Tasamuh (tolerance) and ‘Adalah (justice), which are principles taught to the students.
Evaluating Entrepreneurial Intention Among Pesantren Students: Fostering Empowerment Through Education
Authors: Abdurrohim Abdurrohim , Kusaeri Kusaeri
Published: November 2024

This article aims to evaluate predictors and triggering factors of Muslim entrepreneurial intentions and their relationship to Islamic education, particularly in Islamic boarding schools as indigenous educational institutions. The study employs systematic literature review on two databases, namely Institute Of Education Sciences (ERIC) and Scopus, with the assistance of Publish or Perish version 8, spanning from 2015 to 2024. A total of 27 articles were found, with international index quality, consisting of 8 articles in Q1, 11 in Q2, 6 in Q3, and 2 in Q4, mostly using quantitative approaches. Meanwhile, the research objects consist of countries with Muslim populations, ranging from Indonesia, Pakistan, Iran, Malaysia, Bangladesh to Nigeria. Six instruments were identified for evaluation purposes, divided into two aspects: first, internal aspects including 1) empathy, 2) self-efficacy and internal locus of control, and 3) spiritual and religiosity motivation, and second, external aspects namely 1) moral obligation, 2) prior experiences, and 3) perceived behavioral support. Additionally, 4) leadership was also identified. All these factors serve as recommendations for policymakers to formulate and develop Islamic boarding school curriculum.
The Role of Religious Education on Islamic Legal Awareness in Relation to Marriage in Kuantan Hilir: Case Study of Unrecorded Marriage Practices
Authors: Desminar Desminar , Firdaus Firdaus , Halim Syaflin , Suci Wahyuni
Published: November 2024

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This research aims to implement Islamic Religious Education (PAI) to raise awareness of Islamic law regarding unregistered marriages in the Kuantan Hilir District. Employing a qualitative method with a case study approach, primary data was gathered through in-depth interviews with 3 sources and direct observation of 12 perpetrators of serial marriages. Secondary data was collected from various related literature sources. The findings revealed 12 couples in the area engaging in unregistered marriages, predominantly due to pregnancy out of wedlock, with two cases involving arranged marriages. Understanding Islamic law underscores the significance of registering marriages at the Office of Religious Affairs (KUA) to safeguard the legal rights of partners and children, particularly in instances of pregnancy out of wedlock. Knowledge of Islamic marriage procedures underscores the imperative of complete registration at the KUA, especially in cases of pregnancy out of wedlock. Awareness of the legal consequences emphasizes the curtailment of rights for children and wives from unregistered marriages, particularly in situations of out-of-wedlock pregnancy. Attitudes towards Islamic legal education stress its role in diminishing the incidence of unregistered marriages and underscore the importance of marriage registration, particularly in cases of out-of-wedlock pregnancy. The experience of addressing unregistered marriage cases underscores the significant legal issues faced by such couples, particularly concerning children born out of wedlock without registration. Overall, this research underscores the criticality of marriage registration and Islamic legal education in safeguarding the legal rights of spouses and children.
Transformation of Education: Pattern of Integration of Science in Learning at UIN Antasari Banjarmasin
Authors: Hudaya Hairul , Barni Mahyuddin
Published: November 2024

This research aims to analyze the pattern of integrating knowledge in learning at UIN Antasari Banjarmasin. It has become a core issue at State Islamic Religious Higher Education Institutions (PTKIN), especially after the status change of several Islamic higher education institutions from STAIN or IAIN to UIN. This status change has had significant consequences on the shift in the fields of study at UIN, which were originally focused solely on Islamic sciences and have been expanded to include general sciences, both social and natural sciences. Many issues remain unresolved regarding the implementation of knowledge integration in the faculties at UIN Antasari, ranging from policies on knowledge integration in learning, the patterns of knowledge integration practiced by lecturers, and the extent to which lecturers respond to research on knowledge integration. The patterns of knowledge integration employed by some lecturers in the learning process include relating or presenting Quranic verses and Hadiths in the teaching of general subjects, and relating or presenting general knowledge in the teaching of Islamic studies. The integration models include informative and complementary approaches. The method used in this research is qualitative descriptive, which involves capturing the state of institutions, communities, and other entities based on the facts found. The research findings indicate that the pattern of knowledge integration involves lecturers relating Quranic verses and Hadiths in the teaching of general subjects, and integrating general knowledge in the teaching of Islamic studies, as well as using informative and complementary models.
Integrated Characterization of Expanding-Solvent Steam-Assisted Gravity Drainage (ES-SAGD) Processes by Using a Heat-Penetration Criterion within a Unified, Consistent, and Efficient Framework
Authors: Yang Shikai , Yang Daoyong
Published: November 2024

The hybrid solvent-steam injection [e.g., expanding-solvent steam-assisted gravity drainage (ES-SAGD)] is the most promising method to enhance heavy oil recovery; however, it is quite a challenge to reproduce the experimental measurements and in-situ observations because of the complicated multiphase flow behavior resulting from the coupled mass and heat transfer. In this work, an integrated technique has been developed and applied for the first time to dynamically and accurately characterize an ES-SAGD process within a unified, consistent, and efficient framework. By taking the competitive impact between heat energy and solvent dissolution, a generalized heat-penetration (HP) criterion has been derived and integrated with a numerical simulator to characterize the dynamics of solvent/steam chamber propagation conditioned to the production profiles during hybrid solvent-steam processes. This generalized HP criterion allows us to not only dynamically calculate temperature profiles beyond a solvent/steam chamber interface (SCI) but also accurately and pragmatically quantify mass and heat transfer inside the diluted oil drainage zone as well as the solvent/steam chamber. Also, comprehensive effects of the thermally sensitive co/countercurrent flows are examined with a series of multiphase relative permeabilities. Such an integrated technique has been successfully validated by reproducing the measured solvent/steam chambers in 3D physical ES-SAGD experiments. Good agreements between the simulated and measured production profiles (i.e., injection temperature, pressure, and flow rate) have been made throughout the entire production period. Not only have the measured solvent/steam chambers been reproduced but also sensitivity analyses have been performed to investigate the influences of multiphase flow behavior, solvent concentration, and grid dimension. It is found that the diffusion/dispersion coefficients and thermal properties are dependent on temperature and solvent concentrations, competitively affecting the calculated temperature distributions. Moreover, gas-liquid relative permeabilities can impose a significant impact on the SCI moving velocity as well as the oil drainage front. Such an integrated approach considerably reduces the simulation uncertainties and complexities, offering a straightforward and effective means of dynamically reproducing the observed solvent/steam chambers within a unified, consistent, and efficient framework.
Investigation of peripheral markers of inflammation in patients with different diagnoses on the psychosis spectrum: an observational cross-sectional study
Authors: Üstün Ezgi Sıla Ahi , Yazıcı Serkan , İlhan Rifat Serav , Can Kazım Cihan , Saka Meram Can
Published: November 2024

Background: Increasing evidence suggests that inflammatory dysfunction may be important across the psychotic spectrum. In this study, we investigated whether there is a difference between different diagnostic groups, in which psychosis is the common pathway, and healthy controls in markers of peripheral inflammation, such as platelet-lymphocyte ratio(PLR), neutrophil-lymphocyte ratio(NLR), systemic inflammatory response index(SIRI) and systemic immune-inflammatory index(SII), determined by haemogram. Our hypotheses are as follows: patients with a common history of psychosis but with different diagnoses have higher severity of peripheral inflammation compared to healthy controls, regardless of the specific diagnosis. In addition, the severity of peripheral inflammation is similar across different diagnoses across the psychosis spectrum.
Results: Before and after correction for age and sex, there was no statistically significant difference in PLR between the groups. However a substantial statistical difference in NLR and SIRI were observed between the groups. According to the post-hoc analysis performed to determine which groups the difference was between, schizophrenia and the healthy control group, schizoaffective disorder and the healthy control group, and autism spectrum disorder and the healthy control group differed in terms of NLR; there was only a significant difference in SIRI between autism spectrum disorder and the healthy control group. In addition, there was a statistically significant difference between groups for SII before and after correction for age and sex; however, when paired groups were evaluated using post hoc analysis, no statistically significant differences were found between any two groups. When comparing disorder groups within the psychotic spectrum, it was observed that PLR, NLR, SIRI, and SII levels were comparable.
Conclusions: Our results showed that several disorders including schizophrenia, schizoaffective disorder and autistic spectrum disorder, with different diagnoses but similarities in terms of a history of psychosis, had increased inflammation compared to healthy controls. This study contributes to the psychosis spectrum approach in that there was no statistically significant difference in the severity of inflammation in disorder groups with a history of psychosis but with different diagnostic categories.However further research is needed to completely understand the psychosis spectrum, as bipolar disorder patients have similar inflammation levels to those without mental disorders.
Dolomite thermochronometry applied in central Apennines: a novel tool for tectonic reconstruction in carbonate rocks
Authors: Zhang Junjie , Arriga Giorgio , Rossetti Federico , Argante Valentina , Kraemer Dennis , Cosentino Domenico , Cipollari Paola , Tsukamoto Sumiko
Published: November 2024

The lack of appropriate thermochronological methods has so far hampered reconstructions of the exhumation/cooling history in carbonate rock regions. In this study, we propose a novel thermochronological tool based on the dolomite thermoluminescence (TL) dating. The closure temperature of the TL peak of dolomite at 360°C is estimated to be 50–70°C. The high saturation characteristics of this signal indicate that the dolomite TL is effective in regions with cooling rates as low as 5°C/Ma. This novel thermochronometry is tested in the central Apennines, where seismogenic, carbonate-hosted normal faults control the neotectonics of the region. Samples collected at the footwall of the Monte Marine Fault show that the dolomite clasts in the fault zone and dolomitized bedrocks forming the northeastern shoulder of the L’Aquila Intermontane Basin have TL ages spanning from 3.57 ± 0.34 to 2.41 ± 0.17 Ma. These new TL ages: (i) provide the first direct age of the onset of the post-orogenic extension in the region, allowing to constrain the long-term evolution of seismogenic faulting in central Apennines, and (ii) demonstrate the potential of dolomite luminescence thermochronometry to reconstruct the exhumation/cooling history of carbonate bedrocks.
Simplified P. falciparum membrane feeding assay using small Petri dishes and gel warmers
Authors: Mlambo Godfree , Thanakornsombut Tassanee , Abhai K Tripathi
Published: November 2024

Studies on Plasmodium falciparum transmission require blood-feeding infectious gametocytes to mosquitoes using standard membrane-feeding assays (SMFAs). SMFAs are routinely performed using electric heating coils or glass membrane feeders connected to a circulatory water bath using tubing and clamps. Each of these approaches is expensive and requires a complex setup, hence restricting the number of assays that can be performed simultaneously. Furthermore, existing methods cannot be easily applied in low-resource field settings. Here we describe a low-cost and simplified method for feeding mosquitoes with an infectious blood meal using 35 mm Petri dishes where temperature is maintained by placing reusable gel warmers on top of the Petri dishes. The intensity and prevalence of infection in mosquitoes (An. stephensi and An. gambiae) fed via a Petri dish overlaid with gel warmers were comparable to mosquitoes fed using standard glass membrane feeders. The methodology described here can be easily applied in low-resource and field settings due to its low cost, ease of set up, and use of easily available supplies such as petri dishes, and reusable gel warmers. We believe a wide range of laboratories can easily adapt this method for P. falciparum transmission studies.
Fractal Scaling Laws in the Universe Distribution of Galaxies
Authors: Macek Wieslaw , Wójcik Dariusz
Published: November 2024

We have argued that a simple nonlinear law could be important for
the origin of the Universe resulting in fractal or multifractal features.
Some scaling of the large-scale mass distribution have also been proposed.
As expected the universal multifractal spectrum obtained for galaxies is
similar to that identified by NASA’s Voyager mission in the nearby Solar System environement.
Hence we have applied the similar method for determination of the reliable
multifractal spectrum of distribution of galaxies on cosmological scales,
based on selected observations from a million of galaxies in the Redshift
Catalog updated in June 2008. We show that the observed spectrum
is consistent with the Cantor set models characteristic for heliospheric
turbulence. The degree of multifractality somewhat varies for nearby
and more remote galaxies, which could be related to some voids in the
large-scale distribution of matter. A possible asymmetry of the spectrum
maybe be attributed to some deviations from the Hubble’s law for the
ideal uniform expansion. On the hundredth anniversary of the discovery
of the first galaxy beyond the Milky Way, we hope that the identification
of fractal scaling laws of galaxies is an important contribution
to ultimate explanations of the distribution of matter in the Universe.
Ultrasensitive detection of CEA biomarker for early diagnosing of colon cancer using MWCNT and ZnS@CdS core-shell quantum dots nanocomposite
Authors: Shamsazar Ali , Soheili-Moghaddam Mahsa , Babaei Behnam , Nasiri Ramin , Mavaei Maryamosadat
Published: November 2024

Background
The Carcinoembryonic Antigen (CEA) is a commonly employed biomarker in the surveillance of individuals diagnosed with colon cancer. The utilization of precise biosensing techniques is imperative in identifying recurrence in individuals who have undergone prior treatment for colon cancer. Electrochemical immunosensors present a straightforward and efficient analytical method for quantifying biomarkers.
Method
In this study, a novel electrochemical immunosensor was constructed utilizing a glassy carbon electrode (GCE) that was modified with a nanocomposite of multi-walled carbon nanotubes (MWCNT) and ZnS@CdS core-shell quantum dots (QDs).
Results
The immunosensor designed in this study demonstrates the ability to detect CEA within a broad linear range spanning from 0.0005 to 2.5 ng/mL, with a limit of detection (LOD) of 0.11 pg/mL. The immunosnesor presented enhanced stability and excellent sensitivity.
Conclusions
Due to the results of the immunosensor in CEA sensing, it can be inferred that this new proposed sensor is a promising device for accurate CEA detection, which will be useful in the relevant physiological processes.