bluuebunny/crossref_metadata_2025 huggingface dataset:
Systematic review and meta-analysis: risk factors for psoriatic arthritis. Part 2
Authors: Pereverzina N. O. , Kruglova L. S. , Korotaeva T. V. , Lila A. M.
Published: May 2022

Psoriasis (PsO) is a chronic immune-mediated disease, in the pathogenesis of which various risk factors (RFs) and genetic predisposition play an important role. The complex interaction of genetic and trigger factors leads to the development of autoimmune and autoinflammatory reactions. Every fourth patient with skin PsO develops psoriatic arthritis (PsA), which, progressing and left untreated, can cause irreversible functional disorders, which necessitates early diagnosis of this disease.

Objective: to identify endogenous risk factors for the development of PsA.

Material and methods. We searched PubMed (MEDLINE), EMBASE, and Google Scholar databases for articles on endogenous risk factors for the development of PsA that were published over the past 10 years (until March 1, 2021). We searched for currently registered trials in the registers of clinical trials of US (ClinicalTrials.gov), of China (Chinese Clinical Trial Registry) and the WHO International Clinical Trial Registry Platform. The statistical analysis was prepared in accordance with the international guidelines for systematic reviews and meta-analysis (PRISMA) using the Statistic SPSS 26.0 program (USA). Meta-analysis was prepared using RevMan 5 software.

Results and discussion. Part 2 of the systematic review included 56 articles on endogenous risk factors for the development of PsA. When preparing a meta-analysis, a statistically significant increase (1.68 times) in the risk of developing PsA in the presence of psoriatic lesions of the scalp was noted (95% confidence interval, CI 1.09–2.61). There was no statistically significant increase in the risk of developing PsA in the presence of inverse PsO. The mean PASI was significantly higher (mean difference 2.64; 95% CI 1.37–3.91) in patients with PsA compared with patients without this disease. Mean duration of illness was also longer (mean difference 2.64 years; 95% CI 1.34–4.50) in patients with PsA than in patients with PsO.

Conclusion: PsO and PsA are multifactorial diseases. RFs not only affect their development, but also determine the characteristics of the clinical course, severity, and the presence of complications. Understanding the risk factors of the development of PsA is important for assessing the prognosis, timely diagnosis, and early initiation of therapy, which will prevent severe forms of the disease and disability in patients.
Undifferentiated connective tissue dysplasia and knee osteoarthritis: clinical manifestations and the state of carbohydrate metabolism
Authors: Popov A. A. , Izmozherova N. V. , Getmanova N. A.
Published: May 2022

Objective: to evaluate the impact of undifferentiated connective tissue dysplasia (CTD) on the clinical manifestations of primary osteoarthritis (OA) in postmenopausal women.

Patients and methods. The case-control study included 38 postmenopausal women with primary knee OA, radiological stage II. The main group included 19 patients who met the criteria for CTD, the control group included 19 patients without CTD.

Results and discussion. Patients in the control group had significantly higher values of body mass index, hip circumference and more pronounced clinical manifestations of menopausal syndrome. Patients in the control group had all clinical components and laboratory criteria of the metabolic syndrome, they also had greater limitations of joint function compared to patients of the main group. In patients with CTD pathogenetic mechanisms of development and progression of OA differ from the metabolic phenotype of OA.

Conclusion. The dysplastic phenotype of OA develops in the absence of metabolic syndrome and with less functional impairment than the metabolic phenotype. The metabolic phenotype of OA is associated with insulin resistance, more pronounced functional and psycho-emotional disturbances.
Therapeutic potential of a drug based on avocado and soy unsaponifiable compounds in the treatment of osteoarthritis: data from Russian and international studies (descriptive review)
Authors: Karateev A. E. , Lila A. M.
Published: May 2022

Slow-acting symptomatic drugs (SYSADOA) occupy one of the leading positions in the complex treatment of osteoarthritis (OA). These drugs have a symptomatic and structure-modifying effect, while they are well tolerated and rarely cause serious adverse reactions (AEs). This review examines the evidence base for the use of one of the most popular SYSADOAs, avocado-soybean unsaponifiable compounds (ASACs, Piascledine 300).

Objective: to provide the most complete analysis of clinical trials of ASACs in OA.

Patients and methods. We performed a search in English-language (PubMed) and Russian-language (eLIBRARY.ru) electronic libraries for publications on clinical studies of the efficacy and safety of ASACs in OA. Among the English-language publications were selected: 3 randomized controlled trials (RCTs) of ASACs and their symptomatic effect (n=587), 2 RCTs of the structure-modifying effect of ASACs (n=562), 1 RCT comparing the effect of ASACs and chondroitin sulfate (n=364), and 1 observational study of ASACs in real practice (n=4185). Among the Russian- language publications, 1 observational study of ASACs in real practice (n=6448) and 5 papers containing data from open clinical trials of ASACs (n=356) were found.

Results and discussion. According to the results of the presented studies, ASACs have proven efficacy in reducing the intensity of pain and dysfunction in knee OA. There are data confirming the structure-modifying effect of ASACs in OA of the hip joint (HJ). This drug is well tolerated: in RCTs, the incidence of AEs during ASACs and placebo usage was comparable. In observational studies (n=10 634), there were no serious AEs associated with the use of ASACs.

Conclusion. There is a robust evidence base for the expediency of the active use of ASACs in knee OA. Given the similarity of the pathogenesis of OA of different localizations, the data of individual successful studies and a favorable safety profile, the use of ASACs can also be considered as a component of the complex treatment of OA of the hip joint, hand joints and spine.
Treatment of osteoporosis in clinical practice: first experience with the Russian generic drug of zoledronic acid
Authors: Toroptsova N. V. , Efremova A. O. , Korotkova T. A. , Dobrovolskaya O. V. , Demin N. V. , Feklistov A. Yu. , Samarkina E. Yu. , Cherkasova M. V.
Published: May 2022

Objective: to evaluate the effect of the generic drug of zoledronic acid on bone mineral density (BMD) and markers of bone metabolism in patients with osteoporosis (OP), as well as possible long-term adverse reactions (AR) 12 months after drug administration.

Patients and methods. The study included 30 postmenopausal women with OP (mean age 64±8 years) who signed an informed consent of participance in clinical observation. Patients received a single dose of generic zoledronic acid (5 mg) as a 15-minute infusion. All patients additionally took calcium and vitamin D. The dynamics of BMD and bone metabolism markers, as well as the safety and tolerability of the drug, were evaluated. Fractures that might have occurred during follow-up should have been reported as ARs.

Results and discussion. During treatment with generic zoledronic acid, the increase in BMD in the lumbar region was 4.9% (p<0.0001), in the femoral neck –2.7% (p<0.01), and in the femur as a whole – 3.0% (p<0.0001). Positive dynamics (increase in BMD>2%) in the spine was detected in 26 (86.7%) patients, in the proximal femur – in 20 (66.7%) patients. There was a decrease in the intensity of pain in both the thoracic (by 62%; p=0.038) and lumbar (by 29%; p=0.022) spine. Three months after the administration of the drug, a decrease in the level of bone metabolism markers was revealed: CTX – by an average of 29.7%, and P1NP – by an average of 25.5%. ARs were post-dose reactions that occurred within the first 48 hours after drug infusion. Remote ARs, fractures of peripheral bones and vertebrae were not recorded.

Conclusion. The use of the generic drug of zoledronic acid has demonstrated its positive effect on BMD and markers of bone metabolism, as well as safety.
Clinical significance of antibodies to the phosphatidylserine/prothrombin complex
Authors: Reshetnyak T. M. , Cheldieva F. A. , Cherkasova M. V. , Lila A. M.
Published: May 2022

Classical serological markers of antiphospholipid syndrome (APS) are antibodies to cardiolipin, antibodies to β2-glycoprotein 1, and lupus anticoagulant. The utility of testing other antiphospholipid antibodies, not included in the classification criteria for improving the diagnosis of autoimmune thrombophilia continues to be debated. The review presents literature data on the study of antibodies to prothrombin and the phosphatidylserine/prothrombin complex in patients with systemic lupus erythematosus and APS.
Symptomatic delayed-acting drugs (SYSADOA): new applications
Authors: Lila A. M. , Taskina E. A. , Alekseeva L. I. , Kashevarova N. G.
Published: May 2022

The review systematizes modern data indicating effective pain control and a significant improvement in the functional activity of patients suffering from osteoarthritis (OA) using pharmaceutical substances of chondroitin sulfate (CS) and glucosamine (GA). The effect of a combination of CS and GA on subclinical inflammation (low-grade inflammation) in the joints, slowing down the progression of OA, reducing cardiovascular risk, metabolic disorders, etc. are discussed. There are promising reports of a possible decrease in overall mortality and mortality from cardiovascular diseases during long-term therapy with symptomatic delayed-acting drugs (SYSADOA). A wide range of pleiotropic effects of CS and HA allows us to classify these drugs as geroprotectors and recommend their use not only in OA, but also in various comorbid conditions.
Qué sabemos y cómo lo contamos: Cultura de datos en la trata de seres humanos
Authors:   Universidad Pontificia Comillas, Castaño Reyero María José , Barrio Lema Clara Isabel ,   Universidad Pontificia Comillas, Díez Velasco Isabel ,   Universidad Pontificia Comillas, Maffeis Pacheco Gizela ,   Universidad Pontificia Comillas, Olaguibel Echevarría-Torres Almudena ,   Unicef Comité Español
Published: May 2022

Este informe corto narra la experiencia del proyecto Cultura de Datos en la Trata de Seres Humanos, liderado por el Instituto Universitario de Estudios sobre Migraciones (IUEM) en colaboración con Unicef Comité Español. Durante más de dos años, el proyecto ha investigado las tendencias, lagunas y retos a la hora de recoger, analizar, compartir y utilizar los datos en materia de trata de seres humanos con el fin de poder tomar mejores decisiones. Una vez hecho el análisis, se ha servido de dos herramientas esenciales para presentar dos posibles soluciones: una estadística y una tecnológica. Con la primera, se ha logrado estimar la “cifra oculta” de víctimas de trata en la Comunidad Autónoma de Madrid para el periodo 2015-2019. Con la segunda, se han sentado las bases para una aplicación tecnológica basada en tecnología blockchain permita el acceso a derechos de las personas en procesos de trata y explotación, así como la interoperabilidad institucional de las organizaciones y autoridades que las asisten.
To whom can God speak?
Authors: King Derek S.
Published: May 2022

The analytic philosopher or theologian is faced with two important tasks when giving an account of Trinity: demonstrate logical coherence and remain faithful to the doctrine as received from the Christian tradition. A good analytic doctrine of the Trinity does both well. This paper examines one modern attempt of this: William Hasker’s pro-Social account. It argues that, despite much good in Hasker’s account, he fails to reckon with difficult passages in the theologian he claims as his greatest ally: Gregory of Nyssa. This paper argues that at least one passage in Gregory is incompatible with Hasker’s pro-Social account.
Clientele network in the district of Barranquilla: the role of intermediaries
Authors: Tuirán Sarmiento Ángel Alberto , Naranjo Cortés Ana María , Murillo Lenis Ciro David , Villalba Ramos Luis
Published: May 2022

Un importante actor interviene en las relaciones clientelares a nivel local y no ha sido estudiado a profundidad: el intermediario o broker. A través de entrevistas con estos actores en el distrito de Barranquilla (Colombia), el presente artículo presenta nuevos hallazgos sobre su clasificación, roles, funciones y las motivaciones que los llevan a hacer parte de estas estructuras políticas.
Effect of Spraying with different Concentrations of Methyl Jasmonate on the Sulforaphane Content of Broccoli Plant
Authors: Shakir Walaa Mahmood , AL-Mahdawe Dr. Muthana Muhamed Ibrahim , Hammadi Mustafa
Published: May 2022

The experiment was carried out during the 2020-2021 agricultural season in the greenhouse of the Baquba nursery/ Diyala Agriculture Directorate, with the aim of studying the effect of spraying with different concentrations of Methyl Jasmonate on the sulforaphane content of the broccoli plant using the soilless cultivation technique. The experiment was implemented using a completely randomized design (CRD) and the study included 4 treatments with nine repetitions for each treatment. The averages were compared at a probability level of 0.05. The study included foliar spraying of broccoli at concentrations of 25,50,75 μmol. l-1 of Methyl Jasmonate As well as a control treatment, the results showed the surprise treatment of the MeJA compound by focusing 25 μmol. l-1, While the average of this trait decreased in the treated plants Mej50 μmol.l-1, which recorded the lowest value for this trait, which was 59.57 μg/gm. Compared to the control MeJA0 μmol.l-1, which recorded a mean of 125.31 μg/g.
Form Factor and Charge Density Distribution Calculations for 58Ni, 70,72Ge Isotopes by Using Skyrme Interaction in NushellX@MSU Code
Authors: Sheehab Nawres T. , Majeed Fouad A.
Published: May 2022

The inelastic electron scattering form factors for several chosen states of the 58Ni and 70,72Ge nuclei that reside in the fp-shell region were examined in this research. NushellX@MSU, a recent version of the shell model code, was used to do the computations. Skyrme effective interactions were utilized to calculate the energy Eigen values and eigen vectors that were used to generate the one body transition densities (OBTD) that were used in the inelastic electron scattering form factor calculations. To determine the inelastic electron scattering form factors, Tassie and Bohr-Mottelson models are used. The experimental data was compared to the estimated inelastic electron scattering form factors and charge density distribution for the examined nucleus.
Radon Concentrations and Risk Factors Evaluation in Iraqi Museum and Al Mustansiriya Old School in Baghdad Using CR-39 as a Solid State Nuclear Track Detector (SSNTD)
Authors: Hameed Doaa M. , Aljanabi Ali T. , Ali Ruaa M. , Alobaidy Wasif O.
Published: May 2022

The current study reports radon gas measurements (Rn) levels of concentration in indoor air at various locations of the Iraqi museum and Al-mustansiriya old school which were conducted using a solid state nuclear track detector (SSNTDs) technique. The samples were randomly distributed over twenty different locations in the Iraqi museum and Al-mustansiriya old school. Radon concentrations (CRn) and risk factors (PAEC (mWL), EP (WLM Y-1), AED (mSv /y) and cancer of the Lungs per 106 person) were calculated, the values of radon concentration were high in the basements (ground floor) and poor ventilation locations (A7 and B1), while the average radon concentration was equal to 168.27±5.89 and 231.88±3.03 Bq/m3, (AED) 5.5±0.32 and 8.32±0.13 mSv/y, (CPPP) 154.63±2.16 and 184.21±1.86, (PAEC) 45.84±1.70 and 39.14±1.31 mWL and (EP) 0.93±0.036 and 1.53±0.022 WLMY-1 in Iraqi museum and Al-mustansiriya old school respectively, all these values are within the permissible limits recommended by the ICRP.
Novel Zinc Oxide Nanostructures Produce by Hydrothermal Method Using different Reactors
Authors: Fahem Mohanad Q. , Hassan Thamir A.A.
Published: May 2022

Zinc oxide (ZnO) nanoparticles were prepared with different structures and morphology by using the hydrothermal method. Multi-shape of reactor autoclaves (hom made) with different diminutions has been used. However, increasing the diameter of the autoclave led to slightly reducing the particles size of ZnO NPs. Therefore, the FESEM images show the semi-hexagonal shape with the big diameter of autoclaves and various shapes depending on the diameter of the autoclave. The energy dispersive spectroscopy (EDS) was appeared the atomic percentage of ZnO NPs decreases with Increase the diameter of the reactor. XRD patterns confirm the structure of ZnO NPs. Raman spectroscopy appeared broad peak at prepare with the smallest diameter and was showing high crystallization of nanostructure and red shifting when increasing the diameter of the autoclave.
Review of Humour Interventions to Reduce Stress, Anxiety, and Depression in Adults
Authors: Susanti Inta , Harmiardillah Sylvi , Faridah Virgianti Nur , Pramestirini Rizky Asta , Magfiroh Isni Lailatul
Published: May 2022

Humour interventions can be utilized for improving health status or as complementary therapy for physical, emotional, cognitive, social, or spiritual illnesses. The aim of this review is to identify the effectiveness of humour interventions on depression, anxiety, and stress in adults. Articles published from 2015 to 2020 were searched from various databases. The PRISMA strategy was utilized to identify articles that met the inclusion criteria. The search resulted in 1701 studies, although only sixteen studies were eligible for final review. Humour interventions are safe, inexpensive, and easy to use, and contribute greatly to reducing stress, anxiety, and depression in the adult population. The types of humour intervention are indirect humour, direct humour, social humour, and self-humiliating humour. All humour interventions were of planned humour. Planned humour was the most usable in all studies. It is recommended that more high-quality studies and follow-up assessments should be carried out for future research.
Potential of C-Phenylcalix[4]Resorcinarene Epoxide Compound as Drug Delivery Agent in Breast Cancer Cells MCF-7
Authors: Fatmawati Dwi Rahmasari , Hidayat Danny Nur Wahyu , Sari Diah Kartika , Putri Rizky Riyami , Jumina Jumina , Kurniawan Yehezkiel Steven
Published: May 2022

Cancer therapy through conventional chemotherapy has been widely applied; however, one of the main disadvantages of chemotherapy is the non-selective targeting of cancer cells which causes various adverse side effects. The development of drug delivery agents that are more selective and effective in cancer therapy needs to be performed so that the drugs have a therapeutic effect and minimize side effects. In this study, the compound C-phenylcalyx[4]resorcinarene epoxide (CFKRE) has acted as a drug delivery agent because it can form host complex interactions with ligands. The CFKRE compound was synthesized through two reaction steps: the condensation and alkylation reactions of the epoxide. The structure was analyzed using FTIR, 1H-, and 13C-NMR spectrophotometers and then tested for in vitro cytotoxicity using the MTT assay. The results showed that 70% yield of CFKRE was obtained. Molecular docking analysis of CFKRE compounds against PDGFR and EGFR proteins showed high binding energy compared to conventional chemotherapeutic agents. Molecular dynamic studies showed that CFKRE compounds could form a host-ligand complex with a −350.4 kcal/mol binding energy. Cytotoxic assay of CFKRE compound against MCF-7 breast cancer cells and Vero cells gave IC50 values of 4.04 and 29.59 μg/mL, respectively. These results indicated that CFKRE compounds are not toxic and have the potential to be utilized as new candidates for drug delivery agents.
Akumulasi logam Pb pada Air, Sedimen, dan Kerang Hijau (Perna viridis) di Perairan Tambak Lorok serta Analisis Batas Aman Konsumsi untuk Manusia
Authors: Kusuma Rizky Budhi , Supriyantini Endang , Munasik Munasik
Published: May 2022

Tambak Lorok merupakan salah satu wilayah di Semarang yang dikelilingi oleh berbagai industri. Tambak Lorok juga menjadi kawasan pemukiman nelayan serta menjadi pusat penjualan hasil laut dengan adanya TPI Tambak Lorok. Limbah buangan industri dan rumah tangga di sekitar Tambak Lorok diduga menyebabkan terjadinya pencemaran logam berat timbal (Pb) di perairan yang tentunya dapat mempengaruhi organisme laut seperti kerang hijau (Perna viridis). Penelitian ini bertujuan untuk menganalisis kandungan logam berat Pb pada air, sedimen dan kerang hijau (Perna viridis) di Perairan Tambak Lorok, Semarang serta mengetahui hubungannya. Penelitian ini dilaksanakan pada bulan Januari – Maret 2021 dengan metode penelitian eksploratif kuantitatif. Analisis kandungan logam berat timbal (Pb) pada air, sedimen dan kerang hijau dilakukan di Laboratorium Teknik Lingkungan Universitas Diponegoro dengan metode AAS (Atomic Absorption Spectrophotometer). Hasil menunjukkan bahwa kandungan logam berat Pb Nilai determinasi (R2) kandungan logam berat timbal (Pb) dalam sedimen di Perairan Tambak Lorok yaitu R2 = 0,40 dan pada air yaitu R2 = 0,07. Hasil analisis korelasi menunjukkan tingkat keeratan hubungan yang kuat yaitu dengan nilai r = 0,63, sedangkan pada air terhadap kerang hijau (P. viridis) menunujukkan tingkat keeratan hubungan yang lemah dengan nilai r = 0,26.    Tambak Lorok is one of the areas in Semarang which is surrounded by various industries. Tambak Lorok is also a residential area for fishermen and a center for selling marine products with the Tambak Lorok TPI. Industrial and household effluents around Tambak Lorok are suspected of causing heavy metal lead (Pb) pollution in the waters which of course can affect marine organisms such as green mussels (Perna viridis). This study aims to analyze the heavy metal content of Pb in water, sediment and green mussels (Perna viridis) in Tambak Lorok Waters, Semarang and to determine the relationship. This research was conducted in January – March 2021 with explorative quantitative research methods. Analysis of the heavy metal content of lead (Pb) in water, sediment and green mussels was carried out at the Environmental Engineering Laboratory of Diponegoro University using the AAS (Atomic Absorption Spectrophotometer) method. The results showed that the heavy metal content of Pb The determination value (R2) of the heavy metal content of lead (Pb) in the sediment in Tambak Lorok waters was R2 = 0.40 and in the water was R2 = 0.07. The results of the correlation analysis showed a strong level of a close relationship with a value of r = 0.63, while in water to green mussels (P. viridis) it showed a weak level of a close relationship with a value of r = 0.26.
Potensi Fitoremediasi Mangrove Rhizophora mucronata Terhadap Logam Berat Tembaga di Kawasan Mangrove Park, Pekalongan
Authors: Mentari Refinda Juliant , Soenardjo Nirwani , Yulianto Bambang
Published: May 2022

Pekalongan merupakan kota dengan kegiatan industri tekstil yang cukup besar, terutama industri batik. Banyaknya kegiatan industri menghasilkan limbah yang cukup besar sehingga dapat mencemari lingkungan, salah satunya adalah cemran logam berat. Tembaga (Cu) adalah logam berat yang umumnya digunakan sebagai pewarna mordant dalam pewarnaan tekstil. Fitoremediasi merupakan penggunaan tumbuhan untuk proses dekontaminasi polutan atau masalah pencemaran lingkungan. Mangrove Rhizophora sp. sering diteliti sebagai tumbuhan yang dapat mengakumulasi logam berat, sehingga dapat digunakan sebagai fitoremediator. Penelitian ini bertujuan untuk mengetahui potensi Rhizophora mucronata sebagai fotoremediator logam berat Cu. Analisis kandungan logam berat dari sampel air, sedimen, daun, akar, dan serasah mangrove dilakukan dengan metode AAS (Atomic Absorption Spectophotometry). Hasil penelitian menunjukkan adanya kandungan Cu dalam sampel air, sedimen, daun, akar dan serasah mangrove. Berdasarkan perhitungan Faktor Biokonsentrasi dan Fator Translokasi, mangrove R. mucronata merupakan tubuhan excluder yang mempunyai mekanisme rhizofiltrasi.   Pekalongan has quite large industrial activities, for example is the textile industry. Industrial activities produce large amounts of waste that can pollute the environment, for example heavy metals.  Copper (Cu) is commonly used as dye mordant in textile dyeing. Phytoremediation is the use of plants for the process of decontamination of pollutants. Mangrove Rhizophora sp. is often studied as a plant that can accumulate heavy metals, so it can be used as a phytoremediator. This research was conducted to determine the potential of R. mucronata as a phytoremediation agent for heavy metals (Cu). Samples of water, sediment, leaves, roots, and mangrove litter were analyzed for heavy metals content using the AAS (Atomic Absorption Spectophotometry) method. The results showed that water, sediment, leaves, roots, and mangrove litter contained heavy metals Cu. Based on the calculation of bioconcentration factor and translocation factor, R. mucronata is an excluder plant that has rhizofiltration mechanism.
Pengaruh Bioaktivator EM4 Terhadap Proses Degradasi Pupuk Organik Cair Cymodocea serrulata
Authors: Pradiksa Ony Ilham , Setyati Wilis Ari , Widianingsih Widianingsih
Published: May 2022

Penggunaan pupuk anorganik yang berlebih dan secara terus menerus memiliki dampak negatif bagi lingkungan dan dapat merusak tanah. Upaya yang dapat dilakukan untuk mengurangi dampak negatif dari pemakian pupuk anorganik yaitu menggantinya menggunakan pupuk organik. Penelitian bertujuan untuk mengetahui pengaruh pemberian volume bioaktivator EM4 yang berbeda dalam pembuatan pupuk serasah Cymodocea serrulata terhadap kadar C-organik, N,P,K dan rasio C/N. Metode penelitian yang digunakan yaitu eksperimental dengan menggunakan rancangan penelitian RAL (Rancangan Acak Rangkap). Hasil penelitian menunjukkan pupuk organik cair Cymodocea serrulata memiliki kandungan C-organik berkisar antara 1,51% hingga 2,65% (nilai tertinggi pada kontrol, terendah pada perlakuan 40 ml EM4), N berkisar antara 0,70% hingga 1,54% (nilai tertinggi pada kontrol, terendah pada perlakuan 60 ml EM4), P berkisar antara 0,26% hingga 0,73% (nilai tertinggi pada perlakuan 40 ml EM4, terendah pada kontrol), K berkisar antara 0,41% hingga 0,58% (nilai tertinggi pada perlakuan 40 ml EM4, terendah pada kontrol), serta rasio C/N berkisar antara 1,6 hingga 2,28 (nilai tertinggi pada perlakuan 60 ml EM4, terendah pada kontrol). Berdasarkan hasil penelitian dapat disimpulkan bahwa pemberian bioaktivator EM4 dapat meningkatkan jumlah bakteri sehingga proses degradasi bahan organik dapat berlangsung lebih cepat dan dapat mempengaruhi hasil akhir nilai C-organik, N, P, K, serta rasio C/N.Cymodocea serrulata; Fermentasi; POC; Unsur Hara  The excessive and continuous use of inorganic fertilizers has a negative impact on the environment and can damage the soil. Efforts that can be made to reduce the negative impact of using inorganic fertilizers are replacing them with organic fertilizers. The study aimed to determine the effect of giving different volumes of EM4 bio activator in the manufacture of Cymodocea serrulata serasah on levels of C-organic, N, P, K, and C/N ratio. The research method used is experimental by using the RAL research design (Duplicate Randomized Design). The results showed that Cymodocea serrulata liquid organic fertilizer had C-organic content ranging from 1.51% to 2.65% (the highest value was in the control, the lowest was in the 40 ml EM4 treatment), N ranging from 0.70% to 1.54%. (highest value in the control, lowest in the 60 ml EM4 treatment), P ranged from 0.26% to 0.73% (the highest value in the 40 ml EM4 treatment), K ranged from 0.41% to 0, 58% (the highest value in the 40 ml EM4 treatment, the lowest in the control), and the C/N ratio ranged from 1.6 to 2.28 (the highest value in the 60 ml EM4 treatment, the lowest in the control). Based on the results of the study, it can be concluded that the administration of EM4 bio activator can increase the number of bacteria so that the degradation process of organic matter can take place more quickly and can affect the final results of C-organic, N, P, K, and C/N ratios.
Pressure Transient Analysis of CO2 Rich Gas Reservoir using Pseudo Pressure Approach
Authors: Jan Khair , Jokhio Sarfraz Ahmed , Memon Khalil Rehman , Tunio Abdul Haque
Published: May 2022

This study involves pressure transient analysis of
rich gas reservoir using pseudo pressure approach. Pressure
transient or any other analysis in gas reservoir can be interpreted using pressure, pressure square or pseudo pressure
approach. Previously the pressure tests in gas reservoir were interpreted with diffusivity equation solved for liquid
(using simple pressure approach). But unfortunately in case of gas reservoir the properties of gas are highly affected
with change in pressure. This problem was firstly addressed during 70's by Al-Hussainy and Ramey, when they
conceived the idea of real gas pseudo pressure function, which laid the basis for all gas pressure transient analysis
and rate transient analysis equations to be solved in terms of pseudo pressure approach rather than pressure
approach, but their work is only limited to the sweet gas. Pressure dependence of gas properties is further
complicated when natural gas contains higher amount of contaminant gases such as
and
. The main
objective of this research is to employ the different approaches of pseudo pressure function in pressure transient
analysis of gas reservoir with high concentration of
. Furthermore this study involves the comparative analysis of
results estimated with different pressure approaches.
A Review Study-Use of Different Shapes of Twin Towers High Rise building under Seismic Loading
Authors: Pal Ankit , Kumawat Mahendra , Choudhary Mayank
Published: May 2022

It is observed that there are different-different types of high-rise buildings in the world with different shape and sizes.
These buildings are mainly designed for seismic and wind load. Therefore it is required to take new ideas of
construction and research on that so that the chances of wind and seismic failure can be reduced. After reviewing
various papers it is necessary to analyze different shapes of twin towers in multistoried building under seismic zone
as per Indian standards.
Why Projects Fail
Authors: Giri Utkarsh , Aggrawal Akash , Pandey Shubham
Published: May 2022

Projects that do not meet the original time, cost 8 quality requirements are said to be failed Projects.
Four Pillars of Project: Man, machine, money 8 managements; if any of the four pillars get disturbed the building of
projects fails. Research reveals that project management in many firms 8 companies currently ranges from
undisciplined to confusion. Most of the project failure is related to the time, cost 8 quality paradigm is the motivation
of research on this topic. This paper examines some of the issues 8 casual factors of projects failure.
Searching time reduction of dies by implementing ABC analysis in Automotive Industry
Authors: Darawade Suyog , S Patil , Abdagire Madhavi , Suryawanshi Hemant , Kulkarni Purushottam
Published: May 2022

This paper clarifies the execution of ABC analysis in store division of press part producing industry to improve the die
searching time of all procedure of the organization .This examination depends on execution of ABC analysis
framework and end of various sorts of misfortune from the organization .it tends to be seen that actualizing the ABC
framework will prompts the major gainful change in die searching time reduction, just is likewise improve it
workplace for instance improving the normal working ,improving visual die searching time. ABC method of inventory
control involves a system that controls inventory and is used for materials and throughout the distribution
management.
An Analytical Approach to find out the Efficient Design of Intz Water Tank as per Different Breeze Speed of India
Authors: Chawla Sapan , Jamle Sagar , Meshram Kundan
Published: May 2022

Because of colossal need by the general population, water must be put away and provided by their necessities. Water
request isn't steady for the duration of the day. It changes hour to hour. To supply steady measure of water, we must
store water. So, to full fill the open water need, water tank should be developed. Limit storehouses and overhead tanks
are used to store water, liquid oil, oil-based merchandise and relative liquids. The power assessment of the store or
tanks is about the comparable free of the substance thought of the thing. All tanks are arranged as split free
structures to discard any spillage. This undertaking gives more or less, the speculation behind the arrangement of
liquid holding structure (Elevated roundabout water tank with domed rooftop and cone shaped base) utilizing
working stress strategy method. Components are configured in working pressure technique. Breeze speed from
33m/sec to 55 m/s has used in this work along with Fani cyclone effect of 52 m/sec for some areas.
A Review on Base Shear Reduction by using same Grade of Concrete by Optimizing Size of Column Member
Authors: Khan Aasif , Pal Ankit
Published: May 2022

India is the fastest growing economy in the world and infrastructure plays a very important role in it. The Construction
of high rise buildings in India is growing day by day. Therefore new ideas and venture are needed to make the building
safe, economic and durable. The base shear reduction by using Optimum Size of column in Top Floors in Multistoried
Building under seismic loading is the one of them. It reduces the size of column at the top levels of the building to reduce
its self-weight.
Methodology for selection of optimum interference fit for enhancing performance of external gear pumps
Authors: S Jayakumar , Patil Vijayagowda R , H Madhusudan B
Published: May 2022

External gear pumps are the heart of mobile hydraulic equipment in the mining sectors where it requires precise
control of work attachment functions, lubrication of transmissions and oil supply to steering control units. The external
gear pumps encounter many tribological phenomena such as lubrication and wear of gear teeth, an inner profile of
casing, wear plates, and press fitting of journal bearings. The major challenge involved during the design phase is the
optimum selection of required interference dimensions between the shaft plain bushings and its housings such as
bracket and covers. Though the analytical calculations provide some rough initial sizes, it is a time consuming and
tedious process when it comes to different material combinations, non-uniform and unsymmetrical sections of brackets
and housings. Also, it is difficult to include the effect of thermal variations and different surface finish conditions of
mating surfaces in analytical calculations. Optimum interference dimensions are essential to avoid premature failure
of the Pumps due to dislodging of the bushings. In the current study, the required initial interference fit dimensions are
computed based on an analytical method for different materials combinations. Further, the effect of the surface finish
of mating surfaces and thermal expansion of materials are studied using KISSsoft simulation. The validation of the
same has been carried out using an experimental set up with different material and assembly conditions as a
comparative study to find the optimum dimensions.
Modelling of Sheet Metal Process using Finite Element Analysis 2DCAD Model to Find the Optimum Sheet Thickness
Authors: Sahay Amit , Srivastava Vikas , Shivvedi Kamlesh
Published: May 2022

Deep drawing is popular sheet metal forming process. Complex axisymmetric geometries, and certain nonaxisymmetric geometries, can be produced in a few operations in small cycle time. Skill requirement of operator is
relatively less. The basic theories governing the deep drawing are based on application of theory of plasticity to the
deep drawing process. It is very difficult to apply these theories and arrive at a general solution which can handle any
arbitrary geometry. Some simpler ‘mechanics models’ are more appropriate for such cases, though these do not
incorporate all the aspects governing the process. Therefore, design in sheet metal forming, even after many years of
practice, still remains more an art than science due to the large number of parameters involved in deep drawing and
their interdependence. Design of tooling for deep drawing (die, blank holder and punch) has been largely based on
trial and error resulting in loss of time and money and large development cycles. Using the finite element method one
can simulate the process and study the effect of various parameters before finalizing the design. Several simulation
tests were carried out to obtain the most appropriate value for some of the parameter. A computational experiment is
made to explore the effect of process variables on stress distribution and punch load. An elastic-plastic finite element
computational program is developed to simulate successive deep drawing process.
The chemical composition, characterization, and combination effect of Ocimum campechianum leaf essential oils and bio-produced silver nanoparticles against Listeria monocytogenes and Escherichia coli.
Authors: Okafor Florence , Bomma Manjula , Mentreddy S R , Nyochembeng Leopold , Rangari Vijaya Kumar , Khan Salam
Published: May 2022

Metallic nano-particles (NPs), particularly silver nanoparticles (AgNPs) are emerging as biological tools for assessing
the antibacterial, antifungal, and antioxidant properties and to enhance the potential therapeutic efficacy of
botanicals. Basil (Ocimum spp.), rich in various essential oils has been attributed with a wide range of antimicrobial
properties. The aim of this study was to compare anti-bacterial activity of basil (Ocimum campechianum) essential oil,
bioproduced silver NPs and their possible combinations against Listeria monocytogenes and Escherichia coli. The
constituents of essential oil of Ocimum campechianum was analyzed by gas chromatography/mass spectrometry (GCMS). The AgNPs were monitored by visualizing color changes and were characterized by using UV-Vis, FT-IR, SEM, and
TEM. Further, antibacterial activity of basil EO extracts alone, bioproduced silver NPs alone, and their possible
combination activity with basil EO extracts were assessed by measuring turbidity of growth rates of Listeria
monocytogenes and Escherichia coli using BioScreen C analyzer. A total of 20 compounds were identified in the
essential oil accounting for 99.6% of the composition. The oil of O. campechianum contained as main components,
caryophyllane 4, 8- α-epoxy (59.5%), (E)-caryophyllene (11.7%), and (E)-methyl isoeugenol (6.3%), α-Cymene (5.6%).
The presence of AgNPs was confirmed by the excitation of Surface Plasmon Resonance (SPR) using UV–visible
spectrophotometer at 442nm. The FT-IR analysis showed the presence of possible biomolecules needed for reducing
silver ions; SEM and, TEM analysis confirmed the spherical shape and the average particle size (5-50nm). The reduction
in the growth of L. monocytogenes was 66% by EO extract, 42% by bio-produced AgNPs alone, and by 49% by the
combined effect of (EO extract with bio-produced AgNPs). The EO extract of accession PI 652066 reduced the growth
of E. coli by 62%, whereas combined EO extract with bio-produced AgNPs reduced the growth by 25%. However, there
was no inhibition of the growth of E. coli by AgNPs alone. The results suggest that O. campechianum plant extract could
be used as a proficient reducing agent for the bio production of AgNPs and, can be used to treat multidrug resistant
microorganisms and other bio medical applications.
Behavior of Copper Slag Admixed Concrete in Acidic Environment
Authors: Sagili Venkata Narsireddy , Dicha Habtamu Melesse , Patnaik Binaya , Kannekanti Venkatesh
Published: May 2022

Non-conventional building materials are in huge demand these days because of rapid urbanization and huge cost associated with conventional building materials. Sand is majorly used fine aggregate in the preparation of concrete, however heavy depletion of river beds and rising cost of sand have made the builders and construction industry to think about alternative form of fine aggregate. Many alternatives like industrial wastes, different types of slags, stone dust and agro wastes etc. have been tried to fully or partially replace river sand in preparation of concrete and the results have been encouraging. Out of the non-conventional materials, copper slag is one such type which has a capable future to be used as a fine aggregate in preparation of concrete. The initial strength studies carried out have shown that the optimum percentage of copper slag as a partial replacement of sand in concrete is 40%. To ascertain any material as a building material it is highly important that along with the strength aspects of the material the durability characteristics also verified. So as part of durability studies of copper slag concrete, an attempt has been made here to examine the impact of acid attack on copper slag concrete and the effects have been compared with that of normal concrete. M30 grade of concrete has been used for this experimental investigation. The test results indicate that durability of the copper slag concrete found to be higher resistant to HCl as compared H2SO4 and also normal concrete has better resistance to acid and sulphate attack compared to copper slag concrete.
Importance of Staff Training in a Libyan Oil Organisation, with Special Reference to the Libyan National Oil Corporation
Authors: Senoussi Naser Muftah Abdurrhman , Senoussi Ahmed Miftah Abdelrahman
Published: May 2022

The study examines the effectiveness of in-service staff training with special emphasis on staff of the Libyan National Oil Corporation (NOC). The study adopts quantitative approach for the collection of data, using a questionnaire. A methodical review of the literature relevant to staff training has been carried out, analysed and discussed. The aim of the present study was to: “evaluate the effectiveness of training of staff at National Oil Corporation (NOC), Libya.” The objectives were to: examine current training programmes and to assess their values to trainee staff and to know whether staff need to update their technical skills, or learn new methods of undertaking their tasks, identify reasons motivating staff to attend training courses, identify whether training courses are relevant to the needs and requirements of trainee staff, identify whether training is based on the goals, objectives, or plans of the organisation, or whether they are general in nature, and to check whether performance has improved, and identify whether training has helped libyanise semi-skilled and skilled staff within the Corporation by the provision of effective training programmes.
To Design a Continuous Gas Lift Method for Improving Production in a Dead Well: A Case Study
Authors: Muhammad Noor , Tunio Abdul Haque
Published: May 2022

In Petroleum industry the goal of production department is to obtain maximum oil production at minimum expenditures. The oil production from the wells decreases after some period due to decline in reservoir pressure, increase in water cut, water conning etc. in other words the revenue is lost. Therefore, the artificial lift system is installed on the wells depending upon its characteristics. Gas lift system is one of the most popular artificial lift systems to optimize oil recovery employed in petroleum industry. In gas lift system, gas injected into the well through gas lift valves which reduces the density of liquid column in the well which in turn causes the oil to be produced at the surface. This research study is conducted on well named A-1 in an onshore field Alpha, the well is considered dead due to increase in water cut (40%). The objectives of this research study are to unload the well by designing an efficient continuous gas lift method and then optimize the production by varying some parameters. For this purpose, a simulation model of base case well and gas lift case is designed on PROSPER software by entering the PVT properties, well properties and reservoir properties. After that a sensitivity analysis is performed on PROSPER by changing some variables such as; water cut, wellhead pressure, skin factor, gas injection rate and casing pressure. Subsequently designing the model of the well with gas lift method the well started to produce oil at suitable rate. After that the production is optimized by performing sensitivity analysis on some variables and optimum oil production rate vs gas injection rate is obtained.
A Study of Chosen an Optimum Type of Wavelet Filter for De-Noising an ECG signal
Authors: Ahmed Asia Sh , Rijab Khalida Sh , Alagha Salwa A
Published: May 2022

Among various biological signals for the diagnosing of cardiac arrhythmia, Electrocardiographic (ECG) signal is the most significant one. The interesting challenge is an accurate analysis of the noisy ECG signal. Prior to accurate analysis, these signals need for de-noising to remove these unwanted noises in the signal to get an accurate diagnosis. In order to get the best de-noising results, it should have an accurate decision about the filters that we deal with for de-noising the signals. So, in this paper we present a study for choosing the optimum wavelet filter for de-noising the electrocardiograph (ECG) signal. Signals were stored as a one-dimensional matrix and series of procedure were performed to reduce the noise. The wavelets filters were chosen that very close to the original signal after applied a random-noises to the ECG signals to get familiar with the possible noise that can the signal affected with it. Also, estimation the most standard wavelet families namely Symlets, Coiflet, and Daubechies with different methods of threshold and decomposition levels were done. The purposes of this study to conclude the convenient wavelet functions in decomposition, the de-noising and the reconstruction, the method of the threshold, and the optimal decomposition level of the wavelet.
Microcontroller based Hybrid Power Electronics Trainer using PWM Techniques
Authors: Iqbal Muhammad Waqas , Shakeel Awais , Khan Muhammad Talha , Farooq Arsalan , Hassan Waqas Ul , Khan Muhammad Azeem
Published: May 2022

The project is focused on the main concepts of the power electronics field and the related application of some major
components studied in these courses. Initially, different circuits will be designed according to given experiments list
and they will combine up to make a trainer together. The Proteus software will do the designing. Last but not the
least the main factor, which will be making our project trainer different from the other will be the circuity of the
micro controller through which we will be controlling some angle delays and the timing factor of Power Electronic
IC’s circuit with software implementations. In the future, we will be watching our trainer in different universities. We
hope that students should get better knowledge about these labs through our trainer then the present ones.