bluuebunny/crossref_metadata_2025 huggingface dataset:
Efektivitas Pelatihan Integrasi Canva dan Chat GPT sebagai Media Pembelajaran bagi Pendidik di kota Kupang
Authors: Ahmad Rabya Mulyawati
Published: July 2024

Guru di Kota Kupang, Nusa Tenggara Timur, masih menghadapi tantangan dalam memahami dan mengimplementasikan kecerdasan buatan (AI) seperti Canva dan Chat GPT dalam proses pembelajaran karena kurangnya sumber daya, dan infrastruktur teknologi yang diperlukan serta  pelatihan. Penelitian ini bertujuan untuk mengevaluasi efektivitas pelatihan integrasi Canva dan Chat GPT sebagai media pembelajaran bagi pendidik. Populasi penelitian ini terdiri dari para pendidik di Kupang, dengan sampel sebanyak 41 peserta. Pengumpulan data menggunkan instrumen soal, lembar observasi, dan angket presepsi. Metode analisis data yang digunakan adalah analisis deskriptif dan uji t dengan menggunakan SPSS. Hasil penelitian menunjukkan adanya peningkatan signifikan. Pada aspek pengetahuan, terdapat peningkatan rata-rata skor pretest sebesar 32,19 menjadi 78,04 pada post-test. Sementara itu, kemampuan praktis peserta pelatihan juga mengalami peningkatan yang cukup signifikan, dengan skor pretest 33,56 yang meningkat menjadi 73,04 pada post-test.Sedangakn pada aspek presepsi hasil angket menunjukkan bahwa 63,7% responden menyatakan bahwa penggunaan kedua media tersebut sangat efektif, 39% menyatakan efektif, dan 7% menyatakan netral terhadap efektivitasnya.  Hasil penelitian menunjukkan bahwa pelatihan integrasi Canva dan Chat GPT sebagai media pembelajaran memberikan dampak positif yang signifikan terhadap pengetahuan dan keterampilan praktis pendidik di Kota Kupang
Penggunaan Rasch Model untuk Analisis Instrumen Adult Attachment Scale
Authors: Sugitri Pupung , Fitri Susi
Published: July 2024

Penelitian ini dilakukan untuk menganalisa instrumen Adult Attachment Scale (AAS) yang digunakan untuk mengukur gaya kelekatan mahasiswa S1 Fakultas Ilmu Pendidikan Universitas Negeri Jakarta. Responden penelitian terdiri dari 739. Metode penelitian yang digunakan adalah metode deskriptif kualitatif. Rasch Model digunakan untuk mendapatkan butir soal yang fit. Analisa ini dilakukan dengan bantuan software Winsteps yang kemudian data dari analisis rasch model ini dijelaskan secara deskriptif. Berdasarkan analisis yang di dapat pada INFIT MNSQ dan OUTFIT MNSQ untuk tabel person dan item nilai rata-rata secara berurutan adalah 1,00 dan 1,01 nilai idealnya adalah 1,00 artinya semakin mendekati 1,00 maka semakin baik. Kemudian untuk INFIT ZSTD dan OUTFIT ZSTD nilai rata-rata pada tabel person -0,2 dan -0,2. Sementara itu pada tabel item adalah -0,3 dan -0,1. Nilai idealnya adalah 0,0 artinya semakin mendekati nilai 0,0 maka kualitas semakin baik.
Texto para Discussão 2889
Authors: Abbade Eduardo Botti
Published: July 2024

Este estudo investigou dez indicadores estratégicos analisados pela Organização para a Cooperação e o Desenvolvimento Econômico (OCDE), com o propósito de verificar a performance do Brasil em comparação aos países-membros desta organização. Os indicadores examinados foram: i) captações de água; ii) tratamento de água poluída; iii) resíduos municipais; iv) sobrepeso ou obesidade populacional; v) Índice de Restrição Regulamentar de Investimento Direto Estrangeiro (Foreign Direct Investment Regulatory Restrictiveness Index – FDI RRI); vi) geração de eletricidade; vii) acidentes de trânsito; viii) taxa de desemprego; ix) exportações por tamanho de empresa; e x) importações por tamanho de empresa. O Brasil apresenta desempenho comparável ao dos países-membros da OCDE em todos os indicadores avaliados. Ademais, foram destacadas algumas fragilidades metodológicas inerentes ao processo de avaliação dos indicadores da OCDE. Tais vulnerabilidades apontadas potencialmente prejudicam a avaliação do Brasil, tendo em vista principalmente sua vasta extensão territorial, com abundância de recursos naturais, grande diversidade populacional e diferenças expressivas entre as Grandes Regiões do país.
Effectiveness of Organizing Crossing Transport Services in the Maritime Area of Riau Islands Province
Authors: . Narima , Akhyari Edy , Septiawan Armauliza
Published: July 2024

Researchers took the research theme: Effectiveness of Organizing Crossing Transport Services in the Maritime Areas of Riau Islands Province. Ferry transportation is a mode of sea transportation available in the Riau Islands sea area as public transportation of goods by motorized vehicles. The purpose of this research is to find out the effectiveness of public crossing transportation and all its limitations, as well as to find out the scheduling patterns that occur in pioneer transportation services and commercial transportation. Meanwhile, the theoretical basis used to measure effectiveness is Duncan's theory (in Richard M. Steers, 1985:53) which measures the effectiveness of a program in an organization into 4 (four) aspects of achievement as indicators. Namely: (1) organizational characteristics; (2) adaptation characteristics (environment); (3) worker characteristics and (4) management characteristics. Meanwhile, the method used is a qualitative descriptive approach through fact finding, which studies problems in society in certain situations. The results of the short-term research are that there is an increase in accessibility on the pioneering trajectory and long-term local economic growth and improving the welfare of border communities.
Abstraction, Conceptualization, Disambiguation, Ideation, Innovation, Objectivization, Quantification, and Theorization in the Social Sciences: New Pillars for Contemporary Social Sciences Research
Authors: Mandavilli Sujay Rao
Published: July 2024

In many of our previous papers published over the years, we had developed and propounded concepts such as fuzzy logic, the theory of paradoxes, the certainty uncertainty principle for the social sciences, innovative methods for the social sciences, and had also explained the importance of inductive approaches, grounded theory, and nomothetic rule building. We had also stated the importance of practicalism as a core component of the philosophy of science. In this paper, we state the importance of abstraction, conceptualization, ideation, innovation, quantification, theorization, objectivization and disambiguation in the social sciences, and explain all of these concepts in detail. We also refer to them as the “pillars of social sciences research methods and techniques”, or “the guiding principles or the guiding forces in the use or employment of social science research methods and techniques, and social science research activity”. These approaches are necessary because social sciences research is mostly qualitative; these techniques could impart quality and objectivity to social science research in a way that other techniques cannot. These are different from the philosophy of science or the philosophy of social science, and these we anticipate would guide and drive much of social science research enterprise in the twenty-first century and beyond. These are also foundationally different from the objectives of social science research, examples of which could be cultural emancipation, inculcation of a scientific temper, etc. Needless to say, these can be gainfully employed in the non social sciences as well, though this is not our primary focus and emphasis here.
Pharmacogenomics: An Update Review
Authors: Mercy Leona Dasari , Lavanya Areboina
Published: July 2024

Pharmacogenomics studies how genetics affects how drugs affect the human body. The terms genomics and pharmacology are the sources of the field's name, which represents the intersection of genetics and medicine. The discovery of the laws of heredity in 1866 marked the beginning of the area of pharmacogenetics (PGx). The FDA has established PGx testing recommendations, so whenever these 250+ drugs are being reviewed, testing should be considered. Physicians in the fields of pain management, mental health, and cardiovascular health are among those who provide PGx recommendations. Antidepressant medications offer several therapeutic options that are similar, which makes them a prime candidate for the use of PGx. It makes sense that pharmaceutical companies are hesitant to use pharmacogenomics in clinical investigations given its relative youth. Clinical trials and pharmacogenomic testing together have many advantages. Finding populations with risk factors unrelated to the medication itself may also be facilitated by pharmacogenetics. Oral anticoagulants and chemotherapy treatment regimens are now recommended based on a patient's pharmacogenetic condition. When it comes to patient dosing, pharmacogenetic techniques are gradually replacing the traditional method of depending solely on trial and error. The present therapeutic application of pharmacogenetics can also be applied to drug research and development.
Muscular Dystrophies: An Update Review
Authors: Shalini Devarakonda , Alam Jahangir
Published: July 2024

A broad group of illnesses known as muscular dystrophies are defined by pathologic alterations found in muscle tissue following biopsy. A progressive weakening of the skeletal muscles characterises the clinical appearance of these disorders. The most common type of muscular dystrophy is Duchenne Muscular Dystrophy, an X-linked recessive disease. Distal muscular dystrophy is most common in people between the ages of 40 and 60 and primarily affects the lower limbs, such as the hands, feet, arms, and legs. The development of muscle weakness during infancy or early childhood, usually before the age of two, is a common symptom of congenital muscular dystrophy. The majority of MD types frequently result in respiratory issues that affect the diaphragm and other breathing muscles. Several MD subtypes are linked to cardiac arrhythmias or cardiomyopathy. This class of disorders is the main target of gene transfer and gene repair therapies.
The tiniest violin: the male of Loxosceles vallenar (Araneae, Sicariidae)
Authors: Magalhaes Ivan L. F. , Iuri Hernán A. , Brescovit Antonio D. , Pizarro-Araya Jaime
Published: July 2024

In recent years, several endemic species of Loxosceles, violin spiders, have been described from the North-Central Chile biodiversity hotspot, some of which have ambiguous placement within the species groups of the genus. In a recent expedition to the Atacama region, we collected male specimens representing new records of two recently described species: Loxosceles vicentei Taucare-Ríos, Brescovit & Villablanca, 2022 and Loxosceles vallenar Brescovit, Taucare-Ríos, Magalhaes & Santos, 2017 (Araneae, Sicariidae). Males of the latter are hitherto unknown and are here described for the first time. Examination of the morphology of these species revealed characters such as an embolic keel and digitiform median receptacles, which suggest they do not belong in the laeta species group, but rather in the spadicea species group, which is briefly re-diagnosed. With carapace lengths smaller than 2 mm, the newly discovered males of L. vallenar are the tiniest members of the genus. In addition, males of this species bear strong macrosetae in the clypeus, a sexually dimorphic character not previously reported in Loxosceles.
Curvature analysis of concircular trajectories in doubly warped product manifolds
Authors: Sikander Fahad , Fatima Tanveer , Deshmukh Sharief , Elsharkawy Ayman
Published: July 2024

The aim of this research paper was to explore the various characteristics of the doubly warped product manifold, focusing particularly on aspects such as the Hessian, Riemannian curvature, Ricci curvature, and concircular curvature tensor components. By examining the necessary conditions that would classify the manifold as Riemann-flat, Ricci-flat, and concircularly-flat, the study aimed to expand our understanding of these concepts. To achieve this, the research incorporated the application of these findings to a generalized Robertson-Walker doubly warped product manifold scenario. This approach allowed us to identify and analyze the specific circumstances under which the manifold displayed concircular flatness.
Remote laboratory hardware modules based on networked embedded systems
Authors: Fuduric Darko , Žagar Mario , Se Tomislav Se , Orli? Marin
Published: July 2024

Networked embedded microcontrollers integrated into remote laboratory are proposed. Hardware and software architecture responsible for functioning of the laboratory is discussed. Compatibility with existing networks is mandatory, so common TCP/IP stack layer is introduced. Open remote laboratory, based on embedded systems is accessible from anywhere on the Internet.. It is suitable for practical education in microcontroller fundamentals.
From online experiments to smart devices
Authors: Salzmann Christophe , Gillet Denis
Published: July 2024

Online experiments have been available for more than a decade. The integration of online experiments into collaborative environments is more recent. The wealth of client applications/environments, the versatility of possible interaction protocols/technologies and the needs for more autonomous actions impel the evolution of online experiments to the smart device concept. This paper reviews the evolution of an electrical drive experiment and presents the requirements for turning online experiments into smart devices.
Teleoperation of an Experimental Platform of Electrical Machines through the Internet
Authors: Guerra Torres C. , De León Morales J. , Glumineau Alain , Traore Dramane , Boisliveau Robert
Published: July 2024

The remote access to equipment through the Internet becomes an attractive research area. Most current implementations are dedicated to specific applications such as remote laboratory. A remote laboratory offers cost-effective and flexible means for distance learning education and remote experimentation, where students and scientists share the remote access to physical experiments. This paper presents the implementation of an experimental platform of induction motor though the Internet having the following important features: i) easy implementation based on software and hardware, ii) help based on IP telephony, iii) use of several computers to distribute the task. The developed scheme is versatile and robust, allowing the different control and observer actions remotely through the Internet.
Portuguese Universities Sharing Remote Laboratories
Authors: Restivo Maria Teresa , Da Silva Manuel Gameiro
Published: July 2024

This paper describes a pedagogical assignment based on a cooperative work involving teachers/students from two Portuguese universities. As it happens one is the oldest in the country â?? University of Coimbra (UC) - and the other the largest - University of Porto (UP), about 120 km apart.
The authors, believing in the relevance of Information and Communication Technologies (ITs) in teaching/learning methodologies and in cooperative teaching methods worked together to plan this pedagogical experience and to run it in a one semester course.
Students from UC have been introduced to the remote lab at UP and got the first contact with the remote experiments using easily available sound and image resources based on Skype and an IP camera for better image quality. This first contact has been conducted by the first author at UP with support of the second author at UC.
The work will describe briefly the remote experiments used, their inclusion in the course at UC, the associated assessment criteria and, finally, student comments.
Teaching Kinematics and Dynamics of Multibody Mechanical System Using the Object Oriented Language Modelica
Authors: Seabra Eurico Augusto Rodrigues , Machado José Mendes
Published: July 2024

A new modeling language, called Modelica, for physical modeling is being developed in an international effort. The main objective is to make it easy to exchange models and model libraries for different domains, such as, mechanical, pneumatics, electrical, hydraulics, and others. The design approach builds on non-causal modeling with true ordinary differential and algebraic equations and the use of object-oriented constructs stemming from modern software development, (hierarchy, encapsulation) to facilitate reuse of models and model parts. This paper gives an overview of the use of the object oriented language Modelica with the mechanical Multibody Library to model and simulate three-dimensional mechanical systems.
Le pétrarquisme de Ronsard et la culture littéraire du viol
Authors: Maira Daniel
Published: July 2024

Cet article se focalise sur le rapport de force auquel est soumis le corps de la bien-aimée dans les Amours de Ronsard : ce changement de perspective permet de lire à nouveau frais les jeux de séduction qui sont loin d’être innocents. La pertinence de l’expression « culture du viol » est examinée dans un premier temps pour voir s’il est possible, dans un second temps, de l’appliquer à la poésie amoureuse de Ronsard, où sont thématisés des abus ainsi que des relations non-consenties, fussent-elles fantasmées. Un éclairage différent rend plus complexe la lecture de certains sonnets de Ronsard, notamment une lecture qui ne refuse pas l’hypothèse selon laquelle ces sonnets perpétuent la culture du viol telle que pouvaient la produire certaines œuvres littéraires. L’objectif est ainsi d’étudier les ressorts poétiques d’un motif qui traverse le recueil entier et qui définit la posture ronsardienne du pétrarquisme.
« Hélas ! Si tu prens garde aux erreurs que j’ay faites… » Desportes, des néo-pétrarquistes à Pétrarque
Authors: Balsamo Jean
Published: July 2024

Le « pétrarquisme » de Desportes a été lié au corpus des poèmes dont il avait adapté les « lieux » et les formes dans son œuvre, principalement ceux recueillis dans les anthologies néo-pétrarquistes vénitiennes. Cette conception a conduit à une approche analytique, portant sur des pièces françaises et italiennes, isolées de leur contexte. Or ces pièces, développant un même code lyrique voué à la célébration amoureuse, sont liées entre elles par une relation d’intertextualité au canzoniere de Pétrarque. La poésie de Desportes révèle une relation essentielle à Pétrarque, dont le modèle spirituel et non pas seulement thématique et formel, donne à son propre pétrarquisme un èthos particulier, d’ordre pénitentiel, qui le distingue du pétrarquisme néo-platonicien de Du Bellay et du pétrarquisme « gaillard » de Ronsard.
Vrystaat-fokus
Authors: Eloff C.C.
Published: July 2024

No abstract available.
Piet Retief 1883-1983
Authors: Eloff C.C.
Published: July 2024

No abstract available.
Studies in the history of Cape Town
Authors: Van Breda P.
Published: July 2024

No abstract available.
Eerste fabrieken: Die beginpunt van nywerheidsontwikkeling in die Zuid-Afrikaansche Republiek
Authors: Ferreira O.J.O.
Published: July 2024

In 1881 the Volksraad of the Transvaal Republic granted A.H. Nellmapius a concession for the processing of local produce. This was the first step on the road to economic self-sufficiency of the Republic which had only recently regained its political independence. During 1882 Nellmapius in partnership with Isaac and Barnett Lewis and Samuel Marks established a factory east of Pretoria at the present Eerste Fabrieke. By February 1883 they were already producing spirituous liquor. The factory was officially opened on 6 June 1883 by S.J.P. Kruger who was elected president in May 1883. The undertaking, which in due course was taken over by Nellmapius' partners, expanded considerably in the following years. However, a severe setback was experienced when in 1896 the Liquor Law was amended and the sale of alcohol to Blacks on the Rand was strictly forbidden. This led to a steady decline in business and with the occupation of Pretoria by the British forces in 1900 production was finally stopped.
Anesthesia Considerations in Patients Undergoing Spine Surgery with Evoked Potential Monitoring
Authors: Kulkarni Amruta Mihir , Shetty Vijay L.
Published: July 2024

Intra-operative neuromonitoring (IONM) facilitates monitoring of the functional integrity of neural structures under general anesthesia. It aids in early detection of injury and minimizes postoperative neurologic deficit. IONM may be used during spine surgery, where either the blood supply to the spinal cord could be compromised or the surgical procedures where there is manipulation of the spinal cord. Somatosensory evoked potentials (SSEPs) and motor evoked potentials (MEPs) are used to monitor the sensory and motor tracts in the spinal cord, respectively. Preoperatively, a team of surgeons, anesthetists, and neurophysiologists must discuss about modalities of IONM to be used, expected changes, and alarm criteria. Anesthesia drugs need to be appropriately selected to facilitate IONM, as they affect the SSEP and MEP response obtained. Both total intravenous anesthesia and balanced anesthesia technique may be used, with appropriate titration of drugs. False-positive changes in evoked potentials (EPs) must be prevented by a steady anesthesia state and physiologic parameters. It is preferable to have a checklist to follow whenever changes in EP response are observed to rule out surgical, anesthetic, and monitoring-related causes for change in response. Risk–benefit must be assessed before the selection of a patient for EP monitoring as it may be rarely associated with complications such as burns, seizures, and bite injuries to lips, tongue, and endotracheal tube. Teamwork with meticulous planning, preparation, and multidisciplinary communication is essential for the safe conduct of spine surgeries with SSEP and MEP monitoring. In this review, we discuss various considerations for anesthesia management in patients with intraoperative EP monitoring.
El repertorio de la igualdad: visiones políticas sobre familia en Chile
Authors: Sembler Camilo
Published: July 2024

Una serie de transformaciones sociales y culturales recientes han puesto una fuerte presión a las definiciones más convencionales sobre la vida familiar. Como consecuencia, en la actualidad una arena importante de disputas políticas gira en torno a la pregunta qué se entiende por familia, así como su lugar y valor en la sociedad. El objetivo de este artículo es explorar controversias políticas contemporáneas en torno a la familia en Chile. Para ello se realiza un análisis de los discursos ligados a diferentes “centros de pensamiento” (think tanks), los cuales juegan un papel importante en los debates públicos hoy en Chile y se relacionan con distintas adscripciones ideológicas. A través de entrevistas en profundidad a integrantes de estos centros, se exploran sus visiones sobre qué es la familia, su lugar y significado hoy, identificando sus valoraciones sobre los cambios recientes y puntos de vista en disputa. Las conclusiones destacan los distintos modos en que las visiones políticas se adaptan o reaccionan ante las transformaciones de la familia, en especial a las expectativas de igualdad y autonomía en la vida familiar.
Effectiveness of transarterial chemoembolization in combination with lenvatinib and programmed cell death protein-1 inhibition for unresectable hepatocellular carcinoma
Authors: Chisthi Meer M
Published: July 2024

This editorial comments on the study by Ma et al , which delves into the efficacy and predictive factors associated with the combination of transarterial chemoembolization, lenvatinib, and programmed cell death protein-1 inhibition for the management of unresectable hepatocellular carcinoma. Analysing data from a retrospective study involving 102 patients, the treatment showcased a median overall survival (OS) of 26.43 months and a median progression-free survival (PFS) of 10.07 months. Notably, the objective response rate and disease control rate reached 61.76% and 81.37%, respectively. Specific factors such as Barcelona Clinic Liver Cancer (BCLC) Classification B-stage, early neutrophil-to-lymphocyte ratio response, and early alpha-fetoprotein response (> 20% decrease) correlated with superior OS and PFS. The triple therapy exhibited promising efficacy, particularly in BCLC B-stage disease, with prognostic markers aiding in patient stratification. Acknowledging the retrospective nature of the study design, future research should address this limitation and incorporate longer follow-up periods for a comprehensive evaluation of long-term outcomes.
Survival disparities among racial groups with hepatic malignant tumors
Authors: Han Deng , Zhang Zhi-Yu , Deng Jin-Yan , Du Hong-Bo
Published: July 2024

BACKGROUND

Investigating the impact of race on the clinicopathologic characteristics and prognosis of hepatic malignant tumors represents a complex and significant area of research. Notably, distinct differences exist among various racial groups in terms of the clinical manifestations, pathologic features, and prognosis of hepatic malignant tumors.

AIM

To explore the effect of race on clinicopathologic features and prognosis of hepatic malignancies.

METHODS

Data from patients with hepatic malignancies diagnosed between 2000 and 2019 were collected from the Surveillance, Epidemiology, and End Results database and statistically analyzed.

RESULTS

This study included 123558 patients with hepatic malignant tumors, among whom 21078 (17.06%) were Asian, 14810 (11.99%) were Black, and 87670 (70.95%) were white. The median survival times for patients with hepatic malignant tumors of different races were 12.56, 7.70, and 9.35 months for Asian patients, Black patients, and white patients, respectively. The 3-year survival rates for Asian, Black, and white patients were 29%, 19%, and 21%, respectively, and the 5-year survival rates were 22%, 13%, and 15%, respectively. The Kruskal-Wallis test indicated a significant difference in the survival time of patients with hepatic malignant tumors between different races (P < 0.001). Univariate analysis revealed gender disparities in the prognosis among different ethnic groups (Asian: P > 0.05; Black: P < 0.001; White: P < 0.05). Among Black patients, the prognosis was less affected by the degree of hepatic fibrosis than among Asian patients and white patients (Black patients: P < 0.05; Asian patients: P < 0.001; White patients: P < 0.001). Significant differences were observed in the median survival time among patients with hepatic neuroendocrine tumors and hepatoblastomas during pathologic staging between races. Tumor number was inversely related to the prognosis. Cox regression analyses revealed that T stage, M stage, surgery, chemotherapy, alpha-fetoprotein, and tumor size independently influenced prognosis. Age was a specific independent prognostic factor for white patients. Among the tumor stages, N stage is a self-reliant prognostic element specific to white patients. Conversely, radiotherapy and liver fibrosis were not self-reliant prognostic factors for Black patients. Income alone did not independently influence the prognosis of Asian patients.

CONCLUSION

The prognosis of hepatic malignant tumors is better among Asian patients than among Black patients. The prognosis of hepatic malignant tumors among white patients is affected by multiple factors, including age and N stage.
Adipocytes impact on gastric cancer progression: Prognostic insights and molecular features
Authors: Shang Jia-Rong , Zhu Jin , Bai Lu , Kulabiek Delida , Zhai Xiao-Xue , Zheng Xia , Qian Jun
Published: July 2024

BACKGROUND

Adipocytes, especially adipocytes within tumor tissue known as cancer-associated adipocytes, have been increasingly recognized for their pivotal role in the tumor microenvironment of gastric cancer (GC). Their influence on tumor progression and patient prognosis has sparked significant interest in recent research. The main objectives of this study were to investigate adipocyte infiltration, assess its correlation with clinical pathological features, develop a prognostic prediction model based on independent prognostic factors, evaluate the impact of adipocytes on immune cell infiltration and tumor invasiveness in GC, and identify and validate genes associated with high adipocyte expression, exploring their potential diagnostic and prognostic value.

AIM

To explore the relationship between increased adipocytes within tumor tissue and prognosis in GC patients as well as the associated mechanisms and potential biomarkers, using public databases and clinical data.

METHODS

Using mRNA microarray datasets from the Gene Expression Omnibus database and clinical samples from Jiangsu Provincial Hospital, survival and regression analyses were conducted to determine the relevant prognostic factors in GC. Feature gene selection was performed using least absolute shrinkage and selection operator and support vector machine recursive feature elimination algorithms, followed by differential gene expression analysis, gene ontology, pathway analysis, and Gene Set Enrichment Analysis. Immune cell infiltration was analyzed using the CIBERSORT algorithm.

RESULTS

Tumor adipocyte infiltration correlated with poor prognosis in GC, leading to the development of a highly accurate and discriminative prognostic prediction model. Key genes, ADH1B , SFRP1 , PLAC9 , and FABP4 , were identified as associated with high adipocyte expression in GC. The diagnostic and prognostic potential of these identified genes was validated using independent datasets. Downregulation of immune cells was observed in GC with high adipocyte expression.

CONCLUSION

GC with high intratumoral adipocyte expression demonstrated aggressive tumor biology and a poorer prognosis. The genes ADH1B , SFRP1 , PLAC9 , and FABP4 have been identified as holding diagnostic and prognostic significance in GC. These findings strongly support the use of adipocyte expression as a valuable indicator of tumor invasiveness and anticipated patient outcomes in GC.
Do macroeconomic variables really matter in explaining stock market returns in Tanzanian Stock Exchange Market?
Authors: Keregero Chirongo Moses
Published: July 2024

The behaviour of stock markets is characterized by volatility of macroeconomic fundamentals which cause stock prices to move upwards and downwards within a short period of time. Therefore, the current paper examines the effect of macroeconomic variables on stock market returns of firms listed at Dar es Salaam Stock Exchange market. This study used time series data of macroeconomic variables collected from Central Bank of Tanzania and National Bureau of Statistics from 2011 to 2021.The error correction model was used to check the strength of the relationship between the selected macroeconomic variables and stock market returns. The results show that the selected variables have significant effect on the stock market returns. Inflation, Broad Money Supply and Interest rate appear to have positive impact on stock market returns. However, exchange rate reports negative impact on the stock market returns. The findings of the study provide policy insights about the drivers of the stock market returns volatility to enable policy makers to design the effective macroeconomic policies that will help with predicting the pathways to economic growth.
Factors associated with dual sensory impairment in older persons attending the Geriatric Centre in Southwest Nigeria
Authors: O. Obadare Abiola , A. Adebusoye Lawrence , O. Cadmus Eniola
Published: July 2024

Objective: This study examined the prevalence of hearing impairment, visual impairment and Dual Sensory Impairment (DSI) and the risk factors among older personsDesign: A Cross-sectional study where respondents were recruited by systematic random sampling.Setting: A tertiary institution at the Geriatric Centre, University College Hospital, Ibadan, Nigeria.Participants: A total of 388 older persons aged more than 60 years were recruitedInterventions: A semi-structured pretested questionnaire was used over three months.Main outcome measures: Association between ageing, low income, poor quality of life, functional disability, and dual sensory impairment.Results: The mean age of the respondents was 70.2±6.3 years. The point prevalence of HI, VI and DSI were 14.9%, 8.0%, and 1.5% respectively. On logistic regression analysis, the most significant factors associated with HI were having no formal education OR=2.564(1.091-6.024) and previous hospital admission OR=3.473(1.856-6.499), for VI; increasing age OR=1.080(1.022-1.141) and poor income OR=2.941(1.263-6.897) and DSI; increasing age OR=1.224(1.054-1.421).Conclusion: Few (1.5%) older adults experienced DSI in our setting. The association between sensory impairments, age, and socioeconomic factors of poor education and income suggests the need for visual and hearing screening in older adults, particularly those with medical and socioeconomic issues, for early detection.
Nicotine-impaired cognitive and psychosocial behavior and spatial memory deficit: The combined roles of garlic cloves and honey in Wistar rats.
Authors: Uchewa O.O. , Okechukwu N.G. , Kenneth U.G. , Okoronkwo O.S. , Ibegbu O.A. , Cookey-Gam B.T. , Anyigor O.O. , Nwofia O.J.
Published: July 2024

BACKGROUND AND AIM: Nicotine is an additive abused among youths, which gradually becomes behavioral. The aim of this study was to investigate the ameliorative roles of aqueous garlic cloves and honey extract on nicotine-induced cognitive, spatial memory, and psychosocial behavior impairments.
METHODOLOGY: Forty rats were divided into 5 groups of eight. Group A served as control, receiving food and water. All the groups except A received 50mg/kg of nicotine for 14 days. Group B served as the nicotine-untreated group; Group C received 200mg/kg of garlic and 1000mg/kg of honey; Group D received 400mg/kg body weight of garlic and 1500mg/kg of honey; and Group E received 600mg/kg of garlic and 2000mg/kg of honey. Garlic and honey treatment lasts 14 days. Spatial memory, anxiety, social behavior, and cognition were measured using the Morris Water Maze (MWM), elevated plus maze, sociability chamber, and novel object recognition test. Brain homogenate was used to determine biomarkers.  
RESULTS: The acquisition latency was significantly decreased in the high-dose compared to the nicotine-untreated on day 4 of the MWM test at p < 0.05. The discrimination index reduced significantly in the high-dose group compared to the nicotine untreated at p < 0.05. The time spent with both novel rats significantly increased in the nicotine-untreated group and was lowered by the garlic clove extract. Glutathion-S-Transferase (GST), glutathione oxaloacetate (GOT), and Thiobarbituric Acid Reacting Substances (TBARS) were significantly reduced in the garlic extract groups at P<0.05.
CONCLUSION: Garlic cloves and honey enhanced brain cell regeneration, improved spatial memory, cognition, and social behaviors, and decreased anxiety.
Trendy i odpowiedź strategiczna organizacji cyfrowo-medialnych w czasach kryzysu na przykładzie TikToka, Tindera i Twitcha
Authors: Teler Anna
Published: July 2024

The role of the media in the context of the crisis is significant: the informational, opinion-forming, educational, conciliatory aspect and potential of the media is known. The media’s exploitation of the crisis is also known: financial exploitation or social polarization. The media as organizations, however, are themselves operating in a permanent crisis and are looking for a strategic response, which they can – and often must – provide. Because no digital-media organization, understood as an organizational entity engaged in the production and distribution of content in the digital space, operates in a vacuum. They operate in a business environment that is nowadays described as turbulent, hostile, hyper-competitive and high-potential. Therefore, there is a need to analyze the environment, which makes it possible, among other things, to identify trends and build a strategic response based on their instrumentalization and prioritization. Trends in the growth phase were analyzed using infuture.institute’s proposed maps and trend cards for 2022 and 2023, relating them to selected digital-media companies: Tinder, Twitch and TikTok. A mapping of selected trends was carried out based on a modified Eisenhower matrix: the urgent-strategic matrix. As a result of the analysis, observations were made observations on the specificity and importance of the strategic response. Some recommendations for long-term action were also formulated. The purpose of the article is to sustain interest in the discussion of the importance of strategic thinking with strategic foresight and anticipation of the future in relation to digital-media organizations.
Copypasta: internetowa literatura czy przejaw trollingu? Próba zdefiniowania gatunku
Authors: Brzyszcz Anita
Published: July 2024

Copypasta as a genre of an internet texts was born in the first decade of the 21st century in the societies of internet imageboards. Then it expanded the scope of its functioning to social news and social media portals. Due to the fact that copypasta is a heterogeneous genre in aspect of form and content, it’s still evolutioning and it’s located in the borderland of literature, rhetorical forms and other forms of communication, it hasn’t received a scientific operational definition yet. The author of the article, using the research tools of literary studies, rhetoric, netnography and cyber media studies, attempted to characterize copypaste as a separate genre of internet texts, with an emphasis on the determinants of its literariness and rhetoric, and its subordination to communication functions. Usage definitions emphasize two trends which copypasta has evolved into, taking the form of funny stories or simulating a provocative statement in an online discussion as an internet trolling manifestation. The results of the analyzes of texts representing, that the genre indicate its genre similarity to literary forms, e.g. a story, a tale, a blemish; colloquial speech genres, i.e. conversation, gossip and others, as well as rhetorical ones: speeches, appeals, etc. The overriding feature that binds all texts belonging to this genre is their functioning in the virtual web 2.0 space as a kind of verbal meme.
Agresja komunikacyjna a destrukcja racjonalności dyskursywnej
Authors: Sierocka Beata
Published: July 2024

The main thesis of the article – constructed from the standpoint of transcendental-pragmatic communicating philosophy – is to indicate aggression present in today’s media space as the most significant threat to discursive rationality. Elaborating on this thesis required, on the one hand, understanding how previous theories conceptualized aggression, and on the other hand, explaining the specificity of discursive rationality. On this basis, it was possible to propose a different approach to the problem of aggression, which, in subsequent steps, allowed the recognition that (1) due to communicative aggression present in the specific media space shaped by the latest media, the fundamental tendency toward consensus in communicative processes undergoes destruction precisely because of the specificity of this “megamedial” space. This (2) consequently prevents the maintenance of the discursive nature of human rationality, and thus (3) poses a fundamental threat to the existence of the communication community. In a “positive plan”, these diagnoses ultimately point to the principle of co-responsibility and the normative ethical framework based on it as determinants of social practices safeguarding the idea of consensus.
Kultura języka z retoryką w kształceniu humanistyczno-społecznym. Zarys problemu
Authors: Gródź Iwona
Published: July 2024

The topic of the text is to indicate the need to promote the culture of language and rhetoric in the context of humanities education. This is one of the ways to prevent the increase in communication disruptions such as trolling, hating or flaming in the media space. The aim is to respond to the socially signaled need to increase the linguistic awareness of interlocutors in the space of mass communication, improve the quality of the culture of the language used in public and strengthen respect for experts in the field of linguistics and social communication. The result of the considerations is an attempt to indicate the need to include teaching the culture of language with rhetoric (primarily the art of argumentation) into the broadly understood education in the humanities and social sciences. Thanks to it, new generations of participants in global media communication will be able to answer key questions: how to speak versus writing in a cultural and ethical way so that we are listened to versus read? And more importantly, they will be able to practice the knowledge acquired in this area.
Edward Hartwig, przemiana obrazu rzeczywistości w rzeczywistość obrazu
Authors: Aszyk-Treppa Karolina
Published: July 2024

The works of Edward Hartwig, an outstanding Polish photographer, show the confrontation of two different photographic strategies. One of them respects obligations towards the outside world and is characteristic of trends that describe reality as it is seen by the human eye. For the second strategy, the aesthetic and structural qualities of the image as such, its primacy in relation to nature and autonomy as an artistic work are important. The paper will analyze the essential features of both extremely different photographic strategies and explain the nature of their apparent contradiction. An analysis of the structural quality of the image will be used, considering the specificity of the traditional photographic technique. The most representative works from Hartwig’s rich oeuvre will be considered.
Fotografia jako medium sztuki i społecznego oddziaływania. O metafizyce w fotografiach Ireneusza Zejżdżałki z albumu Sedymentacja
Authors: Janiak Mikołaj
Published: July 2024

The article treats photography as a medium of art and a medium of social influence. This perspective makes it possible to capture the essence of the photographic work, which form and content complement each other. The analysis of Ireneusz Zjeżdżałka’s photo-images from the album “Sedimentation” was based on the semiotic theory of information, with a particular emphasis on syntactics, in order to study the role of light in the photographic image: its influence on the form and on the content, including by performing a mediumistic function, i.e. mediating, between the spheres of the sacred and the profane. The purpose of the article is to pay attention to the visual language of the image, which is governed by different rules than the verbal language. To do this, an attempt has been made to present the basic principles of “imago linguae”, with particular reference to the role of light in the photographic image as a “sine qua non” condition for the existence of photography. Thus, the article is an attempt to answer the question of whether light is responsible for creating a message with a metaphysical basis, i.e. one that goes beyond the frames of ordinary sensory cognition.
Alfonso X, Rex Magister. Ochocientos años despúes
Authors: Crego Gómez María
Published: July 2024

Alfonso X nació un 23 de noviembre de 1221. Algo más de ochocientos años después queremos sumarnos a la conmemoración del nacimiento del Rey Sabio con la convicción de que es posible seguir profundizando en su personalidad, el valor de su reinado y su legado intelectual. Proponemos volver sobre la figura de un monarca que contempló el ámbito del saber como una tarea a la que debía entregarse junto a las demás que le correspondían como rey. Su conciencia del lugar político que ocupaba, así como su absoluto interés por el conocimiento del pasado confluyen en una inquietud intelectual que tuvo otros paralelos en su tiempo, es cierto, pero también definen a un rey que no tiene parangón —y éste será su rasgo diferenciador— en cuanto a la concepción pragmática de su misión; un activo intelectual que, en pos del gobierno eficaz de sus reinos, toma la herencia romana y, combatiendo el uso y la costumbre, se dispone a la tarea de perfeccionar los extensos dominios que le han sido encomendados
Road Repair Delay Costs in Improving the Road Rehabilitation Strategy through a Comprehensive Road User Cost Model
Authors: Ferdinand Trestanto  , Sigit Pranowo Hadiwardoyo  , Jachrizal Sumabrata  , Riana Herlina Lumingkewas
Published: July 2024

This study delves into quantifying the adverse effects of road damage on users, particularly focusing on the increased travel time and consequent financial burdens stemming from delayed repairs. Utilizing a comparative method, the research underscores notable reductions in speed and prolonged travel times due to damaged roads, leading to substantial economic losses for road users. To streamline the estimation of road user costs (RUC), the study proposes a simulation model that incorporates varying traffic volumes and repair delays. This model demonstrates a high level of accuracy in estimating RUC, revealing heightened sensitivity to fluctuations in traffic volume and repair delays compared to agency costs. Consequently, the research underscores the imperative of implementing effective repair strategies to alleviate these impacts efficiently, thereby emphasizing the significance of timely infrastructure maintenance in mitigating financial burdens on road users.
La informalidad en el transporte público de la ciudad de Popayán, Colombia
Authors: Ramírez Bolaños John Felipe
Published: July 2024

El estudio analiza el impacto que tiene la informalidad en la prestación del servicio público de pasajeros en la ciudad de Popayán- Colombia. Se determina como la informalidad ha registrado un mayor crecimiento en los últimos cinco años (2018-2023) surgiendo como respuesta a los índices de desempleo y a la inconformidad por parte de los usuarios del servicio formal de transporte en la ciudad. Además se examina como los entes territoriales y nacionales, confrontan dicho fenómeno, que aunque no siendo exclusivamente de la ciudad de Popayán, se establece que no se debe asumir con cierta ligereza, dado que su impacto sobre los modelos formales de transporte tiene alta incidencia y de seguir su comportamiento desmesurado y sin control podría incluso apropiarse de la prestación del servicio, pese a los planes de acción y de mejoramiento del servicio, por parte de los entes del estado colombiano.
Directoras de películas de ficción en Colombia entre 2000 y 2019
Authors: Navarro Sanchez Gloria Esperanza
Published: July 2024

Este capítulo presenta los resultados de una investigación que tuvo por objetivo principal establecer la participación de las mujeres como directoras en el cine de ficción en Colombia entre los años 2000 y 2019. La metodología empleada fue cuantitativa de alcance descriptivo. La muestra estuvo conformada por las películas de ficción, cortometrajes y largometrajes, que aparecían registradas como terminadas o estrenadas en el ámbito nacional entre 2000 y 2019 en la base de datos del Fondo Mixto de Promoción Cinematográfica Proimágenes Colombia. Los resultados muestran que durante el periodo de tiempo estudiado se registraron como terminadas y estrenadas en el ámbito nacional 517 películas de ficción, de la cuales 436 fueron dirigidas o codirigidas por hombres, 69 fueron dirigidas o codirigidas por mujeres, y 11 fueron codirigidas por hombres y mujeres, por lo que la anhelada igualdad de género está aún lejos de convertirse en una realidad en el campo de la realización cinematográfica en Colombia. Sin embargo, entre el primer y el segundo decenio de la muestra hubo aumentos significativos en la cantidad de largometrajes registrados como dirigidos o codirigidos por mujeres, al pasar de seis entre 2000 y 2009, a 27 entre 2010 y 2019, así como en la cantidad de largometrajes que aparecen como codirigidos por hombres y mujeres, al pasar de solo uno en el primer decenio analizado a cinco en el segundo.
GUÍA DE APOYO. TRANSFERENCIA DEL APRENDIZAJE AL PUESTO DE TRABAJO PARA PERSONAL DOCENTE Y GESTOR
Authors:   INSTITUTO ANDALUZ DE ADMINISTRACIÓN PÚBLICA
Published: July 2024

La transferencia es la razón de ser de la formación, la que da sentido al aprendizaje concebido para ser aplicado en la organización, para prestar un mejor servicio público.
INNOGUÍA: GUÍA PARA INNOVAR EN LA JUNTA DE ANDALUCÍA
Authors: SÁNCHEZ PAZ , REY AMALIO
Published: July 2024

El propósito de la Guía es dirigir y acompañar con una metodología ordenada y sencilla a las personas interesadas en desarrollar actividades y proyectos innovadores dentro de la Administración Pública Andaluza.