bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of a Transcriptional Amplification System Based on the PEG3 Promoter to Target Androgen Receptor-Positive and -Negative Prostate Cancer Cells
Authors: Jain Pallavi , Clermont Pier-Luc , Desmeules Francis , Zoubeidi Amina , Neveu Bertrand , Pouliot Frédéric
Published: January 2019

Localized prostate cancer (PCa) is often curable, whereas metastatic disease treated by castration inevitably progresses toward castration-resistant PCa (CRPC). Most CRPC treatments target androgen receptor (AR) signaling. However, not all CRPC cells rely on AR activity for survival and proliferation. With advances in immunotherapy and fluid biopsies for cancer management, expression systems specific for both AR-positive and -negative PCa are required for virus-based vaccines and cell imaging. To target both AR-responsive and non-responsive cells, we developed a three-step transcriptional amplification (3STA) system based on the progression elevated gene-3 (PEG3) promoter named PEG3AP1-3STA. Notably, we report on different genetic modifications that significantly improved PEG3 promoter’s strength in PCa cells. Adenoviruses incorporating PEG3 promoter with and without transcriptional amplification systems were generated. The potential of PEG3AP1-3STA to target PCa cells was then evaluated in vitro and in vivo in androgen-responsive and non-responsive PCa cell lines. PEG3AP1-3STA was shown to be active in all PCa cell lines and not regulated by androgens, and its activity was amplified 97-fold compared to that of a non-amplified promoter. The PEG3AP1-3STA system can thus be used to target advanced AR+ and AR− cells for imaging or immunovirotherapy in advanced PCa.
Targeting Mitochondria for Treatment of Chemoresistant Ovarian Cancer
Authors: Emmings Edith , Mullany Sally , Chang Zenas , Landen Charles N. , Linder Stig , Bazzaro Martina
Published: January 2019

Ovarian cancer is the leading cause of death from gynecologic malignancy in the Western world. This is due, in part, to the fact that despite standard treatment of surgery and platinum/paclitaxel most patients recur with ultimately chemoresistant disease. Ovarian cancer is a unique form of solid tumor that develops, metastasizes and recurs in the same space, the abdominal cavity, which becomes a unique microenvironment characterized by ascites, hypoxia and low glucose levels. It is under these conditions that cancer cells adapt and switch to mitochondrial respiration, which becomes crucial to their survival, and therefore an ideal metabolic target for chemoresistant ovarian cancer. Importantly, independent of microenvironmental factors, mitochondria spatial redistribution has been associated to both tumor metastasis and chemoresistance in ovarian cancer while specific sets of genetic mutations have been shown to cause aberrant dependence on mitochondrial pathways in the most aggressive ovarian cancer subtypes. In this review we summarize on targeting mitochondria for treatment of chemoresistant ovarian cancer and current state of understanding of the role of mitochondria respiration in ovarian cancer. We feel this is an important and timely topic given that ovarian cancer remains the deadliest of the gynecological diseases, and that the mitochondrial pathway has recently emerged as critical in sustaining solid tumor progression.
Influence of Alloy Substrate Treatment on Microstructure and Surface Performances of Arc-Ion Plated Gold-Like Film
Authors: Yu Qinghai , Pei Jingxuan , Huang Jiankang , Zhang Yuejuan , Ma Di
Published: January 2019

Three typical surface pretreatment strategies (grind, drawing, polishing) are employed to explore the influence of alloy substrate treatment on microstructure and surface performances of arc-ion plated TiN and ZrN films. The luminance and color of the films are measured by the color coordinate value of CIELab system (a color system which is defined by the International Commission on illumination). The crystal phases, morphology and microstructure are characterized and analyzed by scanning electron microscope (SEM) and X-ray powder diffraction (XRD). In addition, the anti-alkali, salt corrosion and anti-oxidation performances of films are systematically researched. The results show that the films with grinding pretreatment are more like gold color, “L” values are 77.27 cd/m2 and 80.30 cd/m2. The “b” value of TiN film is 29.96, which is the same as that of pure gold. The “a” value of ZrN film is 0.31, which is the same as pure silver. The density of TiN and ZrN films is the best, and both TiN and ZrN films were crystalline. They have the best anti-alkali and anti-oxidation performance. The films with drawing pretreatment show slant red color and have medium brightness values (74.07–76.37 cd/m2), worse compactness, obvious furrows and holes in their microstructures and worse salt corrosion and anti-oxidation performances. However, the TiN films are in amorphous states. The films with polishing pretreatment have the lowest brightness (72.66 cd/m2), gold-like color, superior compactness and best salt corrosion performance, which have a small number of holes. The TiN films with polishing pretreatment are also in amorphous state. Above all, alloy substrate pretreatment by grinding has the best gold-like color, brightness, compactness and corrosion resistance performance. This work exclusively sheds new light on surface pretreatment of alloy substrate by arc-ion plated films and also provides a reference for corrosion resistance performance of gold-like films.
Recent Advances in Supervised Dimension Reduction: A Survey
Authors: Chao Guoqing , Luo Yuan , Ding Weiping
Published: January 2019

Recently, we have witnessed an explosive growth in both the quantity and dimension of data generated, which aggravates the high dimensionality challenge in tasks such as predictive modeling and decision support. Up to now, a large amount of unsupervised dimension reduction methods have been proposed and studied. However, there is no specific review focusing on the supervised dimension reduction problem. Most studies performed classification or regression after unsupervised dimension reduction methods. However, we recognize the following advantages if learning the low-dimensional representation and the classification/regression model simultaneously: high accuracy and effective representation. Considering classification or regression as being the main goal of dimension reduction, the purpose of this paper is to summarize and organize the current developments in the field into three main classes: PCA-based, Non-negative Matrix Factorization (NMF)-based, and manifold-based supervised dimension reduction methods, as well as provide elaborated discussions on their advantages and disadvantages. Moreover, we outline a dozen open problems that can be further explored to advance the development of this topic.
Carboxyxanthones: Bioactive Agents and Molecular Scaffold for Synthesis of Analogues and Derivatives
Authors: Ribeiro João , Veloso Cláudia , Fernandes Carla , Tiritan Maria Elizabeth , Pinto Madalena M. M.
Published: January 2019

Xanthones represent a structurally diverse group of compounds with a broad range of biological and pharmacological activities, depending on the nature and position of various substituents in the dibenzo-γ-pyrone scaffold. Among the large number of natural and synthetic xanthone derivatives, carboxyxanthones are very interesting bioactive compounds as well as important chemical substrates for molecular modifications to obtain new derivatives. A remarkable example is 5,6-dimethylxanthone-4-acetic acid (DMXAA), a simple carboxyxanthone derivative, originally developed as an anti-tumor agent and the first of its class to enter phase III clinical trials. From DMXAA new bioactive analogues and derivatives were also described. In this review, a literature survey covering the report on carboxyxanthone derivatives is presented, emphasizing their biological activities as well as their application as suitable building blocks to obtain new bioactive derivatives. The data assembled in this review intends to highlight the therapeutic potential of carboxyxanthone derivatives and guide the design for new bioactive xanthone derivatives.
Catalytic Conversion of Carbon Dioxide through C-N Bond Formation
Authors: Li Jing-Yuan , Song Qing-Wen , Zhang Kan , Liu Ping
Published: January 2019

From the viewpoint of green chemistry and sustainable development, it is of great significance to synthesize chemicals from CO2 as C1 source through C-N bond formation. During the past several decade years, many studies on C-N bond formation reaction were involved, and many efforts have been made on the theory. Nevertheless, several great challenges such as thermodynamic limitation, low catalytic efficiency and selectivity, and high pressure etc. are still suffered. Herein, recent advances are highlighted on the development of catalytic methods for chemical fixation of CO2 to various chemicals through C-N bond formation. Meanwhile, the catalytic systems (metal and metal-free catalysis), strategies and catalytic mechanism are summarized and discussed in detail. Besides, this review also covers some novel synthetic strategies to urethanes based on amines and CO2. Finally, the regulatory strategies on functionalization of CO2 for N-methylation/N-formylation of amines with phenylsilane and heterogeneous catalysis N-methylation of amines with CO2 and H2 are emphasized.
Chemical Eustress Elicits Tailored Responses and Enhances the Functional Quality of Novel Food Perilla frutescens
Authors: Rouphael Youssef , Kyriacou Marios C. , Carillo Petronia , Pizzolongo Fabiana , Romano Raffaele , Sifola Maria Isabella
Published: January 2019

Consumer demand for fresh and functional horticultural products is on the rise. Perilla frutescens, L. Britt (Lamiaceae) is a potential specialty/niche crop for consumption and therapeutic uses with high contents of phenolic and volatile compounds. Plant growth, mineral composition, polyphenol profile and aroma volatile components of two perilla genotypes in response to salinity (non-salt control, 10, 20 or 30 mM NaCl) applied as chemical eustressor were assessed. Salinity suppressed growth and yield of both genotypes, although the red-pigmented genotype was less sensitive than the green-pigmented one. Mild (10 mM NaCl) and moderate (20 and 30 mM NaCl) salinity suppressed foliar potassium, magnesium, nitrate and chlorophyll a concentrations of both genotypes and increased the levels of rosmarinic acid, total polyphenols and target aroma volatile components. Green perilla showed higher yield and biomass production and higher content of protein, dry matter, calcium, magnesium, perilla ketone and cis-jasmone, whereas red perilla exhibited higher content of potassium, chlorophyll a, rosmarinic acid, total polyphenols, perilla aldehyde and benzaldehyde. Our findings support that chemical eustressors such as mild to moderate salinity offer valuable means to manipulate phytochemical and aroma profiles.
Biosynthetic Gene Content of the ‘Perfume Lichens’ Evernia prunastri and Pseudevernia furfuracea
Authors: Calchera Anjuli , Dal Grande Francesco , Bode Helge B. , Schmitt Imke
Published: January 2019

Lichen-forming fungi produce a vast number of unique natural products with a wide variety of biological activities and human uses. Although lichens have remarkable potential in natural product research and industry, the molecular mechanisms underlying the biosynthesis of lichen metabolites are poorly understood. Here we use genome mining and comparative genomics to assess biosynthetic gene clusters and their putative regulators in the genomes of two lichen-forming fungi, which have substantial commercial value in the perfume industry, Evernia prunastri and Pseudevernia furfuracea. We report a total of 80 biosynthetic gene clusters (polyketide synthases (PKS), non-ribosomal peptide synthetases and terpene synthases) in E. prunastri and 51 in P. furfuracea. We present an in-depth comparison of 11 clusters, which show high homology between the two species. A ketosynthase (KS) phylogeny shows that biosynthetic gene clusters from E. prunastri and P. furfuracea are widespread across the Fungi. The phylogeny includes 15 genomes of lichenized fungi and all fungal PKSs with known functions from the MIBiG database. Phylogenetically closely related KS domains predict not only similar PKS architecture but also similar cluster architecture. Our study highlights the untapped biosynthetic richness of lichen-forming fungi, provides new insights into lichen biosynthetic pathways and facilitates heterologous expression of lichen biosynthetic gene clusters.
Dietary Factors Associated with Frailty in Old Adults: A Review of Nutritional Interventions to Prevent Frailty Development
Authors: Hernández Morante Juan José , Gómez Martínez Carmelo , Morillas-Ruiz Juana María
Published: January 2019

Frailty syndrome is a medical condition that is characterised by a functional decline, usually from 65 years old on, and creates the need for assistance to perform daily living activities. As the population ages, the need for specialised geriatric care will increase immensely, and consequently, the need for specialised services for the care of these people will increase accordingly. From a nutritional point of view, to control or balance the nutritional status of residents will be essential in order to prevent sarcopenia and, consequently, frailty development. In this line, previous studies have highlighted the association among low energy intake, inadequate intake of protein and vitamin D, and an increased risk of frailty development. However, there is a lack of intervention studies on frail patients, especially in the realm of quality clinical trials. The few studies performed to date seem to indicate that there is a protective role of protein supplementation against frailty syndrome. In this regard, it is tempting to suggest daily 30 g protein supplements to prevent frailty. However, it is well established that excess protein can also be harmful; therefore, specific individual characteristics should be considered before prescribing these supplements. On the other hand, the relevance of other nutritional interventions, such as vitamin D, omega-3, and medium-chain triglycerides, is much more scarce in the literature. Therefore, we encourage the development of new clinical trials to carry out effective therapies to prevent frailty development.
Modifying Serum Plant Sterol Concentrations: Effects on Markers for Whole Body Cholesterol Metabolism in Children Receiving Parenteral Nutrition and Intravenous Lipids
Authors: Plat Jogchum , Baumgartner Sabine , Vreugdenhil Anita C.E. , Konings Maurice C. J. M. , Calkins Kara L. , Mensink Ronald P.
Published: January 2019

Background: Non-cholesterol sterols are validated markers for fractional intestinal cholesterol absorption (cholestanol) and endogenous cholesterol synthesis (lathosterol). This study’s objective was to evaluate markers for cholesterol synthesis and absorption in children exposed to two different intravenous lipid emulsions that rapidly change serum plant sterol concentrations as part of their parenteral nutrition (PN). Methods: Serum samples from two different studies were used: (1) nine PN-dependent children with intestinal failure associated liver disease (IFALD) whose soy-based, plant sterol-rich lipid (SO) was replaced with a fish-based, plant sterol-poor (FO) lipid; and (2) five neonates prescribed SO after birth. In the first study, samples were collected at baseline (prior to FO initiation) and after 3 and 6 months of FO. In study 2, samples were collected at 1 and 3 weeks of age. Results: In study 1, a 7-fold reduction in campesterol, a 12-fold reduction in sitosterol, and a 15-fold reduction in stigmasterol was observed 6 months after switching to FO. Serum cholesterol concentrations did not change, but cholesterol-standardized lathosterol increased (3-fold) and cholesterol-standardized cholestanol decreased (2-fold). In study 2, after 3 weeks of SO, sitosterol and campesterol concentrations increased 4-5 fold. At the same time, cholesterol-standardized lathosterol increased 69% and cholesterol-standardized cholestanol decreased by 29%. Conclusion: Based on these finding we conclude that changes in serum plant sterol concentrations might have direct effects on endogenous cholesterol synthesis, although this needs to be confirmed in future studies. Moreover, we speculate that this changed synthesis subsequently affects intestinal cholesterol absorption.
A Statistical Regression Method for Characterization of Household Solid Waste: A Case Study of Awka Municipality in Nigeria
Authors: Ezeudu Obiora B. , Ozoegwu Chigbogu G. , Madu Christian N.
Published: January 2019

This work contributes to waste management from two major perspectives. Firstly, waste generation in a previously not-studied location—Awka municipality—was sampled and characterized. Secondly, the characterization was done with improved accuracy using a new method called zero-intercept first-order polynomial regression. The proposed method arrives at composition values and per capita values through polynomial regression that considers sampled waste generation data and household size as regressors, respectively. There are no constituents when no waste is generated and there is no per capita waste when household size is zero, therefore, zero-intercept was imposed on the proposed linear regression approach. An 820 by 11 data matrix from a ten-day sampling in Awka Municipality was used to illustrate the proposed approach; eighty percent of the data was used for training, while twenty percent was used for testing. The results from the proposed method proved more accurate when compared with traditional averaging techniques. The results established for the study area are equally in consonance with known results for similar Nigerian locations, such as organic (73.2%), plastic (8.0%), and recyclable (20.3%). The calculated specific loose volume, specific compact volume, the loose bulk density, and compact bulk density are 2.0 × 10−3 m3/kg, 9.9 × 10−4 m3/kg, 500.0 kg∙m−3, and 1010.2 kg∙m−3, respectively. The waste generation rate is 416.9 g/capita/day, the organic waste generation rate is 307.1 g/capita/day, the recyclable waste generation rate is 83.0 g/capita/day, paper and textile waste generation rate is 25.2 g/capita/day, loose waste volume rate is 9.02 × 10−1 dm3/capita/day, and compact waste volume rate is 4.51 × 10−1 dm3/capita/day. The solid waste characters were compared among the three income groups of low, middle, and high income earners and the observed trends are literature compliant with city-specific coloration. City-wide estimations were made based on demography, literature, and the established results that would aid waste management planning.
Abnormalities and Return: An Exploration of the Concept Fan 反 in the Laozi
Authors: Wang Zhongjiang
Published: January 2019

Laozi’s concept of fan 反 has many different interpretations. However, except for the fan character in chapter seventy-eight which says “appropriate language seems contradictory (fan 反)” where it obviously refers to contradictions or opposites (xiangfan 相反), all other appearances of this character should be explained as fan 返 (return). Return does not refer to opposites, nor does it refer to cyclicality. This point is illustrated through three main channels: first, we argue that in the Laozi, the character fan 反 was used as a phonetic loan for fan 返. Second, this paper shows that both fan and fugui 复归mean “return.” The third channel attempts to answer the questions of why and where the Laozi needs to advocate for the principle of return.
Sensitivity Enhancement of a Surface Plasmon Resonance with Tin Selenide (SnSe) Allotropes
Authors: Dai Xiaoyu , Liang Yanzhao , Zhao Yuting , Gan Shuaiwen , Jia Yue , Xiang Yuanjiang
Published: January 2019

Single layers of tin selenide (SnSe), which have a similar structure as graphene and phosphorene, also show excellent optoelectronic properties, and have received much attention as a two-dimensional (2D) material beyond other 2D material family members. Surface plasmon resonance (SPR) sensors based on three monolayer SnSe allotropes are investigated with the transfer matrix method. The simulated results have indicated that the proposed SnSe-containing biochemical sensors are suitable to detect different types of analytes. Compared with the conventional Ag-only film biochemical sensor whose sensitivity is 116°/RIU, the sensitivities of these SnSe-based biochemical sensors containing α-SnSe, δ-SnSe, ε-SnSe, were obviously increased to 178°/RIU, 156°/RIU and 154°/RIU, respectively. The diverse biosensor sensitivities achieved with these three SnSe allotropes suggest that these 2D materials can adjust SPR sensor properties.
A Novel Energy-Efficient Contention-Based MAC Protocol Used for OA-UWSN
Authors: Wang Jingjing , Shen Jie , Shi Wei , Qiao Gang , Wu Shaoen , Wang Xinjie
Published: January 2019

A hybrid optical-acoustic underwater wireless sensor network (OA-UWSN) was proposed to solve the problem of high-speed transmission of real-time video and images in marine information detection. This paper proposes a novel energy-efficient contention-based media access control (MAC) protocol (OA-CMAC) for the OA-UWSN. Based on optical-acoustic fusion technology, our proposed OA-CMAC combines the postponed access mechanism in carrier sense multiple access with collision avoidance (CSMA/CA) and multiplexing-based spatial division multiple access (SDMA) technology to achieve high-speed and real-time data transmission. The protocol first performs an acoustic handshake to obtain the location information of a transceiver node, ensuring that the channel is idle. Otherwise, it performs postponed access and waits for the next time slot to contend for the channel again. Then, an optical handshake is performed to detect whether the channel condition satisfies the optical transmission, and beam alignment is performed at the same time. Finally, the nodes transmit data using optical communication. If the channel conditions do not meet the requirements for optical communication, a small amount of data with high priority is transmitted through acoustic communication. An evaluation of the proposed MAC protocol was performed with OMNeT++ simulations. The results showed that when the optical handshaking success ratio was greater than 50%, compared to the O-A handshake protocol in the literature, our protocol could result in doubled throughput. Due to the low energy consumption of optical communication, the node’s lifetime is 30% longer than that of pure acoustic communication, greatly reducing the network operation cost. Therefore, it is suitable for large-scale underwater sensor networks with high loads.
Multiple Wire-Mesh Sensors Applied to the Characterization of Two-Phase Flow inside a Cyclonic Flow Distribution System
Authors: Ofuchi César Y. , Eidt Henrique K. , Rodrigues Carolina C. , Dos Santos Eduardo N. , Dos Santos Paulo H. D. , Da Silva Marco J. , Neves Flávio , Domingos Paulo Vinicius S. R. , Morales Rigoberto E. M.
Published: January 2019

Wire-mesh sensors are used to determine the phase fraction of gas–liquid two-phase flow in many industrial applications. In this paper, we report the use of the sensor to study the flow behavior inside an offshore oil and gas industry device for subsea phase separation. The study focused on the behavior of gas–liquid slug flow inside a flow distribution device with four outlets, which is part of the subsea phase separator system. The void fraction profile and the flow symmetry across the outlets were investigated using tomographic wire-mesh sensors and a camera. Results showed an ascendant liquid film in the cyclonic chamber with the gas phase at the center of the pipe generating a symmetrical flow. Dispersed bubbles coalesced into a gas vortex due to the centrifugal force inside the cyclonic chamber. The behavior favored the separation of smaller bubbles from the liquid bulk, which was an important parameter for gas-liquid separator sizing. The void fraction analysis of the outlets showed an even flow distribution with less than 10% difference, which was a satisfactorily result that may contribute to a reduction on the subsea gas–liquid separators size. From the outcomes of this study, detailed information regarding this type of flow distribution system was extracted. Thereby, wire-mesh sensors were successfully applied to investigate a new type of equipment for the offshore oil and gas industry.
Reinforcement Strains in Reinforced Concrete Tensile Members Recorded by Strain Gauges and FBG Sensors: Experimental and Numerical Analysis
Authors: Kaklauskas Gintaris , Sokolov Aleksandr , Ramanauskas Regimantas , Jakubovskis Ronaldas
Published: January 2019

Experimental and numerical studies have been carried out on reinforced concrete (RC) short tensile specimens. Double pull-out tests employed rectangular RC elements of a length determined not to yield any additional primary cracks. Tests were carried out with tensor strain gauges installed within a specially modified reinforcement bar and, alternatively, with fibre Bragg grating based optical sensors. The aim of this paper is to analyse the different experimental setups regarding obtaining more accurate and reliable reinforcement strain distribution data. Furthermore, reinforcement strain profiles obtained numerically using the stress transfer approach and the Model Code 2010 provided bond-slip model were compared against the experimental results. Accurate knowledge of the relation between the concrete and the embedded reinforcement is necessary and lacking to this day for less scattered and reliable prediction of cracking behaviour of RC elements. The presented experimental strain values enable future research on bond interaction. In addition, few double pull-out test results are published when compared to ordinary bond tests of single pull-out tests with embedded reinforcement. The authors summarize the comparison with observations on experimental setups and discuss the findings.
‘Come Back at Us’: Reflections on Researcher-Community Partnerships during a Post-Oil Spill Gulf Coast Resilience Study
Authors: Lesen Amy E. , Tucker Chloe , Olson M. G. , Ferreira Regardt J.
Published: January 2019

This paper presents findings from eight post-hoc interviews with individuals representing the key community partner organizations that facilitated and hosted data collection for an in-person mixed-methods survey about disaster resilience and preparedness in three communities on the Gulf Coast (U.S.) impacted by the Deepwater Horizon oil spill and numerous disasters from natural hazards. We submit our analysis of these follow-up interviews with community partners as a case study to provide a set of recommendations for future community-engaged research practices, particularly in the field of environmental and disaster resilience. Input from community partners stressed the importance of engaging with local community brokers to enhance trust in research; researcher-partner communication; and researcher interaction with community residents that respects local knowledge and culture. The partners indicated that even communities that have often been the subjects of post-disaster studies are receptive to research participation, especially when the effects of disasters are long-term and ongoing. Recommendations include using research methodologies that are congruent with post-disaster community characteristics such as educational attainment; collaborating with community partners to disseminate research findings; and incorporating theories and practices that center critical reflection and consider power dynamics when working with communities that have experienced disaster and trauma.
How Eudaimonic Aspect of Subjective Well-Being Affect Transport Mode Choice? The Case of Thessaloniki, Greece
Authors: Vaitsis Panagiotis , Basbas Socrates , Nikiforiadis Andreas
Published: January 2019

In recent years, the relationship between transportation and subjective well-being has been a major subject. Well-being is a factor that can affect travelers’ psychology and transport mode choice. For this reason, policymakers have attempted to improve travelers’ subjective well-being and promote sustainable modes of transport. For a better understanding of these factors, a questionnaire-based survey was conducted to identify the travel eudaimonia aspect of subjective well-being (comfort, safety, autonomy, self-confidence, physical, and mental health), for the various means of transport in the city of Thessaloniki. During the survey, 300 valid questionnaires were completed. The collection of the above data was followed by statistical analysis. The aim of the analysis was to identify the factors of travel eudaimonia that contributed to the mode choice. For that reason, four ordinal regression models were developed to determine how travel eudaimonia affected the usage frequency of the four available means of transport in the city of Thessaloniki (i.e., private car, bicycle, public transport, walking). Walking was rated higher than other modes in all factors, whilst cycling was rated high in physical and mental health, self-confidence, and autonomy, but low in comfort and safety. Public transport scored very low in all factors, demonstrating the poor quality of service provided by the city’s public transport. Moreover, from the ordinal regression models’ results, it could be demonstrated that travel eudaimonia factors had a significant role to play in mode choice. Recognizing the impact of these factors on transport mode choice is particularly useful for policymakers, researchers, and engineers, as it helps them to make informed decisions about what improvements are needed to promote sustainable modes of transport (mainly walking, cycling, and secondarily, public transport).
Go Long or Go Often: Influences on Binge Watching Frequency and Duration among College Students
Authors: Merrill Jr. Kelly , Rubenking Bridget
Published: January 2019

Binge watching, or serial viewing of a single program over an extended period of time, is a relatively new norm in television viewing that is becoming more popular than traditional appointment viewing. Previous research has explored various influences on binge watching; however, the current research is unique in exploring theoretically and empirically grounded predictors of both binge watching frequency and duration of binge watching sessions by means of a survey administered to college undergraduates (N = 651). Data show that binge watching frequency and duration are predicted by two non-overlapping sets of variables. Binge watching frequency was predicted by low self-regulation, greater tendency to use binge watching as both a reward and a form of procrastination, and less regret; while binge watching duration was associated with being female and experiencing greater enjoyment while binging. Self-control did not predict either binge watching frequency or duration, suggesting that alternative theoretical models should be explored. Findings also suggest that scholars should reconceptualize binge watching by including both frequency and duration measures in future studies.
Putting Research to Action: Integrating Collaborative Governance and Community-Engaged Research for Community Solar
Authors: Prehoda Emily , Winkler Richelle , Schelly Chelsea
Published: January 2019

Community solar involves the installation of a solar electricity system that is built in one central location with the costs and benefits distributed across voluntary investors who choose to subscribe and receive credits based on the generated energy. Community solar is gaining attention because of its potential to increase access to renewable energy and to democratize energy governance. This paper reflects on community-engaged research experiences in two rural community case studies in Michigan, USA, focusing on obstacles that were experienced during the research process rather than empirical findings from the research. We highlight difficulties we experienced to help advance a conceptual argument about incorporating collaborative governance strategies to improve community-engaged research for community energy projects. Our reflections illustrate challenges in community-engaged research that are associated with identifying who should be included in the decision-making process, sustaining participation and avoiding exploitation, establishing and communicating final decision-making power, and giving attention to outputs and outcomes of the research. We argue that collaborative governance strategies can help to address these challenges, as we experienced firsthand in our project.
Environmental and Vegetative Controls on Soil CO2 Efflux in Three Semiarid Ecosystems
Authors: Roby Matthew C. , Scott Russell L. , Barron-Gafford Greg A. , Hamerlynck Erik P. , Moore David J. P.
Published: January 2019

Soil CO2 efflux (Fsoil) is a major component of the ecosystem carbon balance. Globally expansive semiarid ecosystems have been shown to influence the trend and interannual variability of the terrestrial carbon sink. Modeling Fsoil in water-limited ecosystems remains relatively difficult due to high spatial and temporal variability associated with dynamics in moisture availability and biological activity. Measurements of the processes underlying variability in Fsoil can help evaluate Fsoil models for water-limited ecosystems. Here we combine automated soil chamber and flux tower data with models to investigate how soil temperature (Ts), soil moisture (θ), and gross ecosystem photosynthesis (GEP) control Fsoil in semiarid ecosystems with similar climates and different vegetation types. Across grassland, shrubland, and savanna sites, θ regulated the relationship between Fsoil and Ts, and GEP influenced Fsoil magnitude. Thus, the combination of Ts, θ, and GEP controlled rates and patterns of Fsoil. In a root exclusion experiment at the grassland, we found that growing season autotrophic respiration accounted for 45% of Fsoil. Our modeling results indicate that a combination of Ts, θ, and GEP terms is required to model spatial and temporal dynamics in Fsoil, particularly in deeper-rooted shrublands and savannas where coupling between GEP and shallow θ is weaker than in grasslands. Together, these results highlight that including θ and GEP in Fsoil models can help reduce uncertainty in semiarid ecosystem carbon dynamics.
The 5E Model of Environmental Engagement: Bringing Sustainability Change to Higher Education through Positive Psychology
Authors: Macharis Cathy , Kerret Dorit
Published: January 2019

What is the role of universities in advancing sustainability? This paper delineates a unique program for promoting sustainability that was applied in Vrije Universiteit Brussels (VUB). The unique characteristics of the program are described in light of the positive sustainability framework. The five components of the program are designed to promote sustainable behavior of participants, through promoting goal-oriented hope: setting a goal; believing that one can successfully achieve the chosen goal (agency thinking); viewing the potential paths for achieving the goal (pathway thinking); and trusting other members of society to follow the same desired goal (social trust). The five components of the program are designed to jointly raise all the elements of hope. It starts with goal setting (estimate), which is aimed at evaluating the impact of the university on the physical environment. Secondly, the entire community of the university should be engaged in achieving the desired goal. The third component of the method is education about the potential options and actions for achieving the designed goal. Then, enabling the achievement of the goal takes place (meaning making it easy). Lastly, participants should be encouraged to pursue the goal by positive rewarding.
A Model for Predicting Energy Usage Pattern Types with Energy Consumption Information According to the Behaviors of Single-Person Households in South Korea
Authors: Kim Sol , Jung Sungwon , Baek Seung-Man
Published: January 2019

Residential energy consumption accounts for the majority of building energy consumption. Physical factors and technological developments to address this problem have been researched continuously. However, physical improvements have limitations, and there is a paradigm shift towards energy research based on occupant behavior. Furthermore, the rapid increase in the number of single-person households around the world is decreasing residential energy efficiency, which is an urgent problem that needs to be solved. This study prepared a large dataset for analysis based on the Korean Time Use Survey (KTUS), which provides behavioral data for actual occupants of single-person households, and energy usage pattern (EUP) types that were derived through K-modes clustering. The characteristics and energy consumption of each type of household were analyzed, and their relationships were examined. Finally, an EUP-type predictive model, with a prediction rate of 95.0%, was implemented by training a support vector machine, and an energy consumption information model based on a Gaussian process regression was provided. The results of this study provide useful basic data for future research on energy consumption based on the behaviors of occupants, and the method proposed in this study will also be applicable to other regions.
The Effect of Value Co-Creation on Social Enterprise Growth: Moderating Mechanism of Environment Dynamics
Authors: Ge Jianxin , Xu Hongjia , Pellegrini Massimiliano M.
Published: January 2019

The traditional approach to demonstrate the growth processes of social enterprise still relies heavily on an internal perspective of resource and capability accumulation. However, it is insufficient to explain why some social enterprises grow quickly while other social enterprises do not. Based on the theory of value co-creation, this paper proposes a theoretical framework of the effect of value co-creation on social enterprise growth. A survey was conducted in China across 29 provinces and municipalities from October 2015 to March 2016, through the efforts of a market research group. The final number of usable questionnaires was 172. Specifically, by employing hierarchical regression models, this paper partially confirms the positive impact of value co-creation on social enterprise growth, while environment dynamics have a negative moderating effect on the relationship between value creation and the growth of social enterprises.
Who Is the Beneficiary of Slack on Corporate Financial Performance and Corporate Philanthropy? Evidence from South Korea
Authors: Chung Seungwha (Andy) , Pyo Hyunsang , Guiral Andres
Published: January 2019

As stakeholder relations vary depending on firm characteristics, the associations among corporate financial performance (CFP), corporate giving, and corporate social performance (CSP) are complex. In this paper, we contribute to the literature by exploring CFP as a predictor of CSP by differentiating the stakeholder groups that firms interact with; that is, primary versus secondary stakeholder relations. Our study also extends the existing literature by examining who the beneficiaries of corporate philanthropy are, and the role played on the CFP/CSP association. By extracting a sample of 52 firms and 312 firm-year observations from the Korea Economic Justice Institute database, we find that while CFP has a positive effect only on primary stakeholder relations, corporate philanthropy has a positive impact on both primary and secondary stakeholder relations. Furthermore, we observe an overall influence of CFP on stakeholder relations when corporate philanthropy is high. Our findings suggest that differentiating multiple stakeholder groups together with the role played by corporate philanthropy provides a more valuable and meaningful analysis of the antecedents of CSP.
A Comparative Analysis on Residents’ Reservation Willingness for Bus Service Based on Option Price
Authors: Zheng Xun , Miwa Tomio
Published: January 2019

Population decline is a pressing issue facing Japan and other developed countries. Local governments in Japan are seeking solutions to insure they meet the daily travel demands of the elderly. Although subsidy for local bus companies is a highly practical policy, a careful investigation to determine its reasonable level is required. This paper investigates the option price of local bus services, that is, the willingness of residents to pay to maintain the services and attempts to gain insights on a reasonable level of subsidy for local bus companies. A comparative analysis among age groups and different city size groups was made. The result showed that elderly residents show a higher option price value than younger and middle-age residents.
Does Bilingual Instruction Impact Students’ Academic Performance in Content-Based Learning? Evidence from Business School Students Attending Bilingual and L1 Courses
Authors: Lin Teng , He Yuanyue
Published: January 2019

Despite the rapid adoption of bilingual programs (English–Chinese) in Chinese higher education institutions (HEIs), concerns have been raised about perceived language hindrance to students’ academic comprehension and performance. In response to these concerns, we investigated the effects of bilingual instruction on content-based learning, and provide empirical evidence after testing influential factors in bilingual environments. Analyzing a sample of 498 undergraduate students enrolled in a fundamental business course at a sample university in China, we found insignificant statistical differences in the students’ academic performance between bilingual and L1 (Chinese) classes. We attribute this to the English language support provided by the university, and show that learning competence can help students minimize language barriers and solve common learning problems facing both bilingual and L1 students. Overall, our paper aimed to identify key determinants of students’ academic performance during bilingual instruction, and provide policy implications for developing desirable bilingual programs in HEIs.
Packaging-Related Food Losses and Waste: An Overview of Drivers and Issues
Authors: Wohner Bernhard , Pauer Erik , Heinrich Victoria , Tacker Manfred
Published: January 2019

Packaging is often criticized as a symbol of today’s throwaway society, as it is mostly made of plastic, which is in itself quite controversial, and is usually used only once. However, as packaging’s main function is to protect its content and 30% of all food produced worldwide is lost or wasted along the supply chain, optimized packaging may be one of the solutions to reduce this staggering amount. Developing countries struggle with losses in the supply chain before food reaches the consumer. Here, appropriate packaging may help to protect food and prolong its shelf life so that it safely reaches these households. In developed countries, food tends to be wasted rather at the household’s level due to wasteful behavior. There, packaging may be one of the drivers due to inappropriate packaging sizes and packaging that is difficult to empty. When discussing the sustainability of packaging, its protective function is often neglected and only revolves around the type and amount of material used for production. In this review, drivers, issues, and implications of packaging-related food losses and waste (FLW) are discussed, as well as the implication for the implementation in life cycle assessments (LCA).
The Influence of Insulation Styles on the Building Energy Consumption and Indoor Thermal Comfort of Multi-Family Residences
Authors: Wang Yupeng , Fukuda Hiroatsu
Published: January 2019

The properties of building envelopes significantly affect indoor building energy consumption, indoor thermal comfort, and building durability. In the current standards for Japanese residential energy efficiency, insulation placement is not well regulated. Meanwhile, it is common in Japan to use air-conditioning intermittently, rather than having the units operate continuously. Therefore, considering specific Japanese lifestyles, we investigated insulation performance. In this research, we: (1) developed the interior insulation to include insulation on walls, ceilings and floors of building units (all of the interior surfaces) to achieve building energy savings by avoiding heat loss through thermal bridges; (2) discussed and demonstrated the effects of high heat capacitance for each of the building components and the thermal bridge by conducting building environmental simulations; (3) conducted simulations in seven cities in Japan and discussed the applicability of these different weather conditions; and (4) compared temperature distributions to investigate differences in indoor comfort with partial heating on winter nights. We demonstrated the energy saving and thermal comfort advantages of interior insulation. This research provides an innovative insulation style based on Japanese lifestyles that contributes to new energy-saving standards and formulations.
Family Structure and Severe Food Insecurity in Maputo and Matola, Mozambique
Authors: McCordic Cameron , Abrahamo Ezequiel
Published: January 2019

The rapid growth of Maputo and Matola (neighbouring cities in Mozambique) has dramatically shifted the vulnerability profiles of these cities. Poor neighbourhoods across these two cities may now face the prospect of becoming food deserts. Scholars have defined African urban food deserts by the co-occurrence of poverty and food insecurity. This study aims to assess the assumed relationship between resource poverty and food insecurity in the African urban food desert concept and to assess the contribution of household demographics to this relationship. Using household survey data collected in 2014 across Maputo and Matola, this investigation demonstrated that inconsistent access to water, electricity, medical care, cooking fuel, and cash was associated with increased odds of severe household food insecurity across both cities. In addition, a nuclear household family structure was associated with reduced odds of severe food insecurity in both cities (even when taking limited resource access into account). These findings suggest that the severe food insecurity vulnerabilities associated with African urban food deserts may differ according to the family structure of households in Maputo and Matola.
Making Ours Mine: Increasing Consumer Acceptance of Access-Based PSS through Temporary Product Customisation
Authors: Tunn Vivian S. C. , Fokker Richard , Luijkx Koen A. , De Jong Silke A. M. , Schoormans Jan P. L.
Published: January 2019

Access-based product-service systems (AB-PSS) have the potential to lower environmental impacts. Currently, a lack of consumer acceptance and, consequently, low adoption levels of AB-PSS are challenges preventing the realisation of their sustainability potential. This study proposes temporary product customisation to lower barriers for the acceptance of AB-PSS. We investigated whether customisation through modifying the appearance of an easily changeable attribute of a typical product, and thereby changing the product personality, could improve consumer acceptance while limiting the impact on sustainability. To explore this, a 3 × 1 between-group design experiment was conducted with consumers who are familiar with offerings similar to the AB-PSS we tested. The results indicate that respondents have a strong preference, as is widely recognised, for typical products in an AB-PSS. Infusing meaning and intangible value into accessed products through customisation can simultaneously lead to wider acceptance in the market and individual consumers’ satisfaction. Our findings confirm that consumer acceptance increases if a product fulfils intangible needs along with functionality needs. The results can be used to think about new ways in which product design can enhance the diffusion of AB-PSS in the consumer market.