bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Speos Method on Increasing Breast Milk among Mother with Post Section Caesaria in Pelni Hospital, Jakarta
Authors: Nurhayati Ety
Published: October 2020

In Jakarta, the proportion of low birth weight is 6.0%. LBW has difficulty adapting to extra-uterine life. This is due to the organ systems' inability, such as the lungs, heart, kidneys, liver, and digestive system. The SPEOS method can be used to increase breast milk production in mothers. This study aims to identify whether there is an effect of the SPEOS method on the increase in breast milk production in post-section caesarian mothers at Pelni Hospital, Jakarta. The sample used was Post-Caesaria Section Patients with 64 respondents. The method used was a quasi-experiment with a pre-test and post-test control group design approach. The statistical test used was the paired-sample t-test, so breast milk production was p-value <0.05. This shows a significant effect between the SPOES method on the increase in milk production in post-section caesarian mothers at Pelni Hospital, Jakarta. It is suggested that PELNI Hospital Jakarta need to implement a new policy so that breast milk production increases with the SPEOS method in Post Sectio patients
Radar Quality Index for a Mosaic of Radar Reflectivity over Chao Phraya River Basin, Thailand
Authors: Mahavik Nattapon , Tantanee Sarintip
Published: October 2020

The weather radar is one of the tools that can provide spatio-temporal information for nowcast which is useful for hydro-meteorological disasters warning and mitigation system. The ground-based weather radar can provide spatial and temporal information to monitor severe storm over the risky area. However, the usage of multiple radars can provide more effective information over large study area where single radar beam may be blocked by surrounding terrain Even though, the investigation of the sever storm physical characteristics needs the information from multiple radars, the mosaicked radar product has not been available for Thai researcher yet. In this study, algorithm of mosaicked radar reflectivity has been developed by using data from ground-based radar of Thai Meteorological Department over the Chao Phraya river basin in the middle of Thailand. The Python script associated with OpenCV and Wradlib libraries were used in our investigations of the mosaicking processes. The radar quality index (RQI) field has been developed by implementing an equation of a quality radar index to identify the reliability of each mosaicked radar reflectivity pixels. First, the percentage of beam blockage is computed to understand the radar beam propagation obstructed by surrounding topography in order to clarify the limitations of the observed beam on producing radar reflectivity maps. Second, the elevation of beam propagation associated with distance field has been computed. Then, these three parameters and the obtained percentage of beam blockage are utilized as the parameters in the equation of RQI. Finally, the detected radar flare, non-precipitating radar area, has been included to the RQI field. Then, the RQI field has been applied to the extracted radar reflectivity to evaluate the quality of mosaicked radar reflectivity to inform end user in any application fields over the Chao Phraya river basin.
The Port Phillip Lime Economy
Authors: Taylor Peter
Published: October 2020

Lime is an essential component of the building industry for it is used to make mortar and to make plaster. Without lime, building construction in Melbourne would have been severely curtailed. Yet, this is an industry rarely written about. Using newspapers as a key source, this article discusses the development of the lime industry from the time of first settlement in the Port Phillip district to the rise of Marvellous Melbourne in the 1880s, key figures in the industry, and their predilection to form cartels.
The Gaol on the Hill: The prelude to and construction of Bendigo’s sandstone gaol
Authors: Edmonds Leigh
Published: October 2020

The gold rushes on the Victorian goldfields of the 1850s increased the population of the new colony seven times over. This created many problems for the new government, not the least of which was an increase in lawlessness which put authorities under severe pressure to house the rapidly growing convict population. Other issues confronting colonial prison administrators were the mobility of the population as gold seekers moved to the latest finds, the presence of a large Chinese population on the goldfields and the housing of the mentally disturbed. At the same time, new philosophies in prison design gave the Victorian government the potential to replace its first, hastily constructed, goals with the latest ‘state of the art’ prisons at strategic locations across the goldfields.
How to make an entrance: Piranesi comes to Ballarat
Authors: Coleridge Edward
Published: October 2020

"The inside front cover of this publication carries an image of CRCAH's front door, the main gateway to the former Ballarat Gaol. It is a magnificent example of nineteenth century masonry work. The massive bluestone blocks were carved and chiselled into a grand classical edifice, making a fitting southern finale in scale and significance to the great range of buildings on either side of Lydiard Street. The remarkable architectural statement of a confident gold rich city runs from the os­tentatious neo-classical railway station at the northern end past the Art Gallery, the Mining Exchange, the palatial former Post Office (now housing the studios of the university Arts Academy) and on along the facades of banks, hotels, theatres and churches, in a melody of styles from palladian to gothic (with some 20th century intrusions) down to the suitably 'redbrick' buildings of the Ballarat School of Mines. Here the road swings round to the west so the range of prison buildings bookend the whole composition with a dramatic solemn coda " -From forum article
Apakah Harga dan Brand Image Berpengaruh Terhadap Keputusan Pembelian?
Authors: Maulida Nurul , Maya Siska
Published: October 2020

Abstract– The purpose of this study is to determine the effect of price and brand image on purchasing decisions. The method used in this research is nonprobability sampling. The sampling technique used in this study was accidental sampling, data collection using a questionnaire. Data analysis uses multiple linear regression. The results showed that price influences purchasing decisions and brand image influences purchasing decisions. Simultaneously brand image has a significant effect on purchasing decisions.

 

Abstrak– Tujuan dari penelitian ini yaitu mengetahui pengaruh harga dan brand image terhadap keputusan pembelian. Metode yang digunakan dalamalam penelitian ini adalah nonprobability sampling. Teknik pengambilan sampel yang digunakan dalam penelitian ini adalah accidental sampling, pengumpulan data menggunakan kuesioner. Analisis data menggunakan regresi linier berganda. Hasil penelitian menunjukkan bahwa harga berpengaruh terhadap keputusan pembelian dan brand image berpengaruh terhadap keputusan pembelian. Secara simulta brand image berpengaruh signifikan terhadap keputusan pembelian.
DEVELOPMENT OF KAP TOOLAND ITS APPLICATION IN ASSESSMENT OF YOUNG FEMALES WITH PCOS.
Authors: Agarwal Shubhi , C Usha Devi
Published: October 2020

BACKGROUND Polycystic ovary syndrome (PCOS) is the most common endocrine disorder amongst women of reproductive age associated with various clinical and psychological manifestations. Promoting awareness and lifestyle modifications is essential to empower the female PCOS population to take health care decisions for the treatment and management. OBJECTIVE Assessment of knowledge, attitude and practice(KAP) among PCOS population is significant in behavioral and lifestyle modification. Thus, the present study was undertaken to develop a KAP tool. METHODS An observational, non-controlled study was conducted using random sampling in the age range of 15-25 years. A total of 600 subjects were screened with the help of a standardized screening questionnaire and the presence of PCOS was confirmed using the Rotterdam criteria (2003).A KAP tool validated by an expert panel was given to the subjects confirmed for PCOS to assess knowledge, attitude and practices. The validity was assessed using exploratory factor analysis. The Spearman-Brown correlation coefficients helped to assess reliability for knowledge, attitude and practice domains, which were found to be 0.83, 0.63 and 0.47 respectively. RESULTS Significant knowledge was found among confirmed PCOS subjects, but had low attitudes and their practices did not commensurate with their knowledge about PCOS and Nutrition. CONCLUSION The present research contributes to the understanding of a growing PCOS epidemic in urban India and document the need to screen knowledge, attitude and practice, to develop supportive interventions addressing quality of life issues to reduce the distress among women with PCOS.
Intoxicação alimentar por Bacillus cereus e Staphylococcus aureus: relato de uma investigação de surto
Authors: Moriconi Patricia Rossi , Lacerda Aldrey Cintia Sgorlon , Rodrigues Elisângela Mara da Silva , Ferreira Ester Nogueira Whyte Afonso , Mazon Elaine Marra de Azevedo , Pinotti Ana Marian Solbiati
Published: October 2020

E­ste trabalho objetivou descrever uma investigação de surto de intoxicação alimentar em um evento realizado no município de Campinas/SP, avaliando as possíveis causas e identificando os agentes etiológicos. Para isso, foram analisados documentos utilizados na investigação epidemiológica (entrevista com comensais), sanitária (roteiro de inspeção sanitária baseado nas legislações vigentes) e laboratorial (análises de alimentos e de material clínico de três pacientes). A investigação epidemiológica mostrou se tratar de uma intoxicação alimentar, ao passo que a investigação sanitária revelou uma série de irregularidades na empresa produtora dos alimentos, como por exemplo, ausência de licença de funcionamento, exposição dos alimentos a temperaturas inadequadas e condições higiênicas ambientais insatisfatórias, sendo essas últimas condições que favorecem e facilitam a multiplicação de agentes patogênicos.  A investigação laboratorial confirmou os agentes bacterianos suspeitos de causar o surto (Bacillus cereus e Staphylococcus aureus) a partir de amostras de sobras de esfiha de carne e de torta de legumes, sustentando as suspeitas obtidas nas investigações sanitária e epidemiológica. O êxito desta investigação se deu a partir da ação integrada de diferentes especialidades oficiais, em esforço mútuo para elucidar as causas­ da ocorrência e a confirmação etiológica, subsidiando as ações políticas de prevenção das doenças transmitidas por alimentos.
Natimortalidade de fetos com peso de 2.500g no municí­pio do Rio de Janeiro: 2008-2017
Authors: Martins Barros Geiza , Bastos Dias Marcos Augusto , Saraceni Valeria
Published: October 2020

Este estudo visa descrever aspectos assistenciais das mulheres que tiveram natimortos com peso maior ou igual a 2.500g e que morreram antes ou durante os seus nascimentos, de mães residentes no municí­pio do Rio de Janeiro (MRJ) nos anos de 2008 a 2017. Trata-se de um estudo descritivo, retrospectivo, utilizando dados secundários, integrando variáveis relacionadas aos óbitos destes bebês, a partir dos dados secundários dos Sistemas de Informação sobre Mortalidade (SIM) e Nascidos Vivos (SINASC). A coleta dos dados ocorreu durante os meses de janeiro a março de 2019. A taxa de natimortalidade no perí­odo estudado foi de 10,1/1000 nascidos e a taxa de natimortalidade de fetos com 2500g ou mais foi de 2,42/1000 nascidos. A faixa etária materna mais frequente foi de 20 a 34 anos, a escolaridade de 4 a 11 anos de estudo, o parto vaginal foi a principal via de nascimento, o sexo masculino apresentou maior frequência de natimortalidade, a grande maioria dos óbitos foi antes do parto e tiveram como local de ocorrência, os hospitais. As afecções originadas no perí­odo perinatal foram as mais prevalentes e o declí­nio dos óbitos não investigados se deu em 2010, possí­vel relação com a obrigatoriedade da vigilância destes óbitos a partir deste ano.
Gestação com suspeita/diagnóstico de infecção pelo Zika Ví­rus
Authors: Do Espí­rito Santo Soares Laura , Soares Ferreira Cruz Gênesis Vivianne , Blanco Silva Bernardino Fabiane , Lopatko Kantoviscki Andréia Lara , Rossi Everton , Ribeiro Moraes Dias Manuela
Published: October 2020

Trata-se de estudo qualitativo, utilizando como instrumento de coleta de dados entrevista semiestruturada. A saturação dos dados se deu pela riqueza dos dados, procedendo a análise de conteúdo, na modalidade da análise temática. Foram entrevistadas 04 gestantes, uma puérpera e um cônjuge. Após análise, foram identificadas duas categorias temáticas, sendo elas: os saberes sobre o Zika Ví­rus e suas complicações; e repercussões e apoios cotidianos na gestação com suspeita ou diagnóstico de Zika Ví­rus. O saber mobilizado pelas pessoas que vivenciam o agravo enfatizou o aspecto estrutural da cabeça do bebê, que apontou preocupação com a questão da deficiência e da aparência fí­sica. As repercussões no cotidiano da gestante e do seu entorno promoveram a reorganização dos ví­nculos sociais, alcançando dimensões da vida privada, com destaque para dimensão socioeconômica e espiritualidade. A experiência diante dessa situação se repercutiu nas projeções e nos planos familiares, no compasso de questões morais que sedimentam as ações e as escolhas na esfera pública e privada.
A importância da educação em saúde para as gestantes durante o acompanhamento do ciclo graví­dico puerperal
Authors: Vieira Pereira Peixoto Ivonete , Rodrigues Lobato de Nazaré Marcela Beatriz , Lira dos Santos Raiane , Pereira Peixoto Karen Dayana , Silva Bandeira Francisco Jadson , Pinheiro Martins Marcelly Beatriz
Published: October 2020

Introdução: A gravidez é um evento de muita significação na vida da mulher e permeada por valores, transformações e momentos especiais, sendo experimentados de formas diferentes na vida de uma mulher. Objetivo: Descrever a importância da educação em saúde para as gestantes durante o acompanhamento do ciclo graví­dico-puerperal em uma Unidade Básica de Saúde em Belém do Pará. Método: produto de um projeto de extensão institucionalizado pelo Centro Universitário do Pará (CESUPA), composto por uma equipe multidisciplinar de acadêmicos dos cursos de: do 7º perí­odo de Enfermagem, 4º perí­odo de Medicina, 6º perí­odo de Odontologia e 5º perí­odo de Nutrição. A ação foi na Unidade Básica de Saúde, no Bairro do Guamá em Belém-Pa. Participaram 12 gestantes, foram inclusas as que frequentavam regularmente o pré-natal, exclui-se as que iniciaram o pré-natal no 2º trimestre. A captação foi durante as consultas pelos profissionais de saúde. A análise foi de Bardin. Resultados: As gestantes devem ter acesso í  ação educação para esclarecer e prepará-la para alterações vivenciadas, prepara-las para decisões ao parto, puerpério e amamentação. Considerações finais: O conhecimento das gestantes sobre o pré-natal contribui para o cuidado ao binômio mãe-filho, a extensão universitária e um fator contributivo para melhorar a inter-relação com os profissionais de saúde, academia e comunidade.
LEGAL ASPECTS OF MEDICAL REFORM’S IMPLEMENTATION: POLAND’S EXPERIENCE FOR UKRAINE
Authors:   Poltava State Agrarian Academy, Dubovych Olesia , Vasylieva Nataliia ,   National Academy for Public Administration under the President of Ukraine, Drohomeretska Iryna ,   Municipal non-profit enterprise "Vinnytsia City Clinical Hospital №1"
Published: October 2020

The academic paper has analyzed the experience of implementing the reform of the health care system in Poland, taking into account the legal regulation of the measures taken.The attention is focused on the basic stages of the medical reform, as well as the features of each stage. The legal aspects of the process of reforming the health care system in Poland have been investigated; they determine the sources and methods of financing health services, the level of quality of health care and the functioning of the health care system in general. The individual components of the health care system related to compulsory health insurance have been described. Based on the analysis, it has been proved that in practice there is no single universal model of financing the health care system. The experience of the functioning of health care in Poland has shown that the experience of reforming the health care system in Poland can be successfully implemented in the practice of medical reform in Ukraine, provided that the historical, economic and cultural features of the country are taken into account. It has been concluded that in order to improve measures to reform the medical system of Ukraine it is necessary to develop and implement measures aimed at the development of health insurance and medical self-government. Introduction of health insurance in Ukraine will help improve medical services, improve the management of the entire health care system and its financing.
TRADE UNION CONTROL IN THE CONTEXT OF TRADE UNION RELATIONS WITH PUBLIC ADMINISTRATION ENTITIES IN UKRAINE
Authors:   State Archives of Odessa Region, Lukyanchuk Petro
Published: October 2020

At the present stage of development of the trade union movement in Ukraine, the issues of determining the place and role of trade unions in the system of public administration as a subject of public administration and the institution of civil society are relevant. The lack of legal recognition of social partnership, and its replacement by social dialogue has led to a decrease in the influence of trade unions on social protection and the lack of trade union control. The latter has been replaced by public control exercised in Ukraine by various public associations. The aim of the article: As a result, trade unions began to participate as advisory bodies rather than as defenders of workers' labor rights. Accordingly, the relations with the subjects of public administration have changed. The aims of the article: to demonstrate that not only in the Ukrainian practice of public administration, but also in the science of public administration, no attention is paid to the problem of trade union control and the relationship between trade unions and public administration entities. Object of research: trade unions as a subject of public administration. Research methodology: a review of Ukrainian literature sources on trade union control and its impact on the relationship of public administration. The results obtained: in the Ukrainian science of public administration there are no publications on trade union activities and trade union control; the mechanisms for building relationships between trade unions and public administration entities are not defined; there is a constant perception that trade unions are public associations and their main role is to conduct a dialogue between employers, authorities and employees; there is no clear conceptual view of the trade union control process, which causes many legal conflicts. Practical significance: scientific substantiation of the use of the concept of "trade union control" in legal practice and in the activities of public administration, its clear definition makes it possible to influence the rights of workers and influence the development of social policy by public administration.
INTERNATIONAL STANDARDS ON COMBATING MONEY LAUNDERING AND CORRUPTION CRIMES: SOME ASPECTS OF INVESTIGATIONS
Authors:   National Academy of Internal Affairs, Gorbenko Ganna
Published: October 2020

The article analyzes international standards on combating money laundering and corruption crimes. The evolution of The FATF Standards, which have been revised to strengthen global safeguards and further protect the integrity of the financial system by providing governments with stronger tools to take action against financial crime, has been investigated. At the same time, these new standards address new priority areas such as corruption and tax crimes. The aim of the article is to compare international legal acts that regulate the field of anti-money laundering and anti-corruption. The research methodology: the functional and analytical methods of comparative legal research were used as the most appropriate. In comparison with AML/CFT law, the international legal requirements regarding anti-corruption compliance are very general. Many countries do not have laws and regulations on anti-corruption compliance. Companies develop their compliance programmes based on international law, foreign law that has transnational application. Certain provisions of the above-mentioned international legal acts, in addition to their scope, regulate the investigation of crimes related to money laundering, terrorist financing and corruption crimes. The main results: the implementation of international standards in national law in some way unifies the approaches to the investigation of complex crimes, which are often combined in a scheme, and allows the introduction of effective methods of investigating such crimes.
GLOBAL VIEW OF THE MAIN REASONS TERRORISM EMERGENCE
Authors:   KROK University, Mawlood Sarteep
Published: October 2020

Whereas global lives under globalization system, many things became easy to be available for normal and non-extremist people meanwhile the same thing is true for the extremist and terror groups. When resources become more then the reasons become more and diverse as well especially when the subjects are about human rights, deprivation of basic services such as speaking in their mother tongue, perform religious rituals, living in very hard situation and poverty, lack of having enough teaching centers, schools, medical centers. In another hand using violence, planting hating and enmity among people by using media, technology, fliers or any other means which motivate extremist, terror , attract other feeling, is another problem nowadays. The article aims to know the main and maximum reasons, root causes of violence, extremist and terror, study every single situation a lone, what are motivations behind them, what can we do understand the situation better, diagnose the problem, what is the best way for solving the issue, how the procedures will be, what we can do in case if we could not reach to the right point in future, how we can distinguish cases from time to time and from place to place according to its case and situation, how to lessen hating, violence, and several other issues that mentioned during the article. Based on it, the article contains several researches, studying, diverse other articles meanwhile different ways and methods are used to have maximum information about the issue in different lines and corners, which can be useful for further researchers or study.
FORMATION OF METHODOLOGICAL COMPETENCE OF FUTURE TEACHERS OF GEOGRAPHY
Authors:   Volodymyr Vynnychenko Central Ukrainian State Pedagogical University, Romankova Kateryna
Published: October 2020

The article reflects the features of methodological training of future teachers of geography in higher education institutions. The purpose of the article is to form the methodological competence of future teachers of geography, which would meet modern requirements for the training of specialists in higher education institutions. Methodological approaches (systemic, personality-oriented, competence-oriented, activity-based, contextual, environmental) and principles of methodical training (scientific, professional orientation, integrativeness, coherence, connection of theory and practice, consciousness and activity, systematicity and sequence, strengthening creative orientation, variability, personal orientation). The components of methodological competence, such as methodological knowledge, methodological skills, pedagogical reflection are revealed their mastering by students during the study of the discipline "Methods of teaching geography" and during pedagogical practice is shown. Certain difficulties of students in mastering methodological knowledge and skills are outlined and a number of organizational and pedagogical measures that will contribute to the formation of methodological competence are identified on their basis. The purpose of training is defined as the formation of methodological competence of the future teacher of geography. A description of the process of formation of methodological competence of students - future teachers of geography through various forms of education (lectures, seminars, practical classes), independent research and teaching activities.
SODIUM-GLUCOSE COTRANSPORTER-2 INHIBITORS AS NEW STRATEGY OF CHRONIC HEART FAILURE MANAGEMENT
Authors: Herashchenko Andrii S. , Fedorov Sergiy V.
Published: October 2020

Introduction: Heart failure (HF) affects over 26 million people worldwide and is associated with high morbidity and
mortality. Diabetes mellitus (DM) is a common cause of HF in current clinical practice. In recent years, the prevalence
of DM has increased considerably, with an estimated 439 million adults worldwide projected to be affected by the year
2030. The aim: To was evaluate of modern trials in patients with diabetes and heart failure treated by Sodium-glucose
cotransporter-2 inhibitors.
Materials and Methods: The database from PubMed for the last 10 years has been reviewed.
Conclusion: SGLT2i, namely Empagliflozin, has good results in their recovery from patients with HFrEF, but the results
of their use in patients with HFpEF are currently questionable and need further study.
THE EFFECT OF LOW FREQUENCY ELECTROMAGNETIC RADIATION ON THE MORPHOLOGY OF DENTAL AND PERIODONTAL TISSUES (EXPERIMENTAL INVESTIGATION)
Authors: Markovskaya Iryna V.
Published: October 2020

Introduction: Low intensity electromagnetic effects possess a high biological activity, reduce the adaptive reserves of the body, impair immunity, adversely affect the functional
state of the organs and body systems.
The aim of the study was to identify in the experiment the effect of low-frequency electromagnetic radiation on the morphological state of the dental and periodontal tissue.
Materials and methods: The experiment was conducted on WAG rats weighing 180–200 g, during which two groups were formed: group 1 (control group) included 12 WAG
rats, which were not performed any manipulations; the rats of group 2 (investigation group) (n=12) for 30 days were exposed to a 70 kHz low-frequency alternating electric
field (5th frequency range) daily from 9.00 to 12.00. To simulate a low-frequency 70 kHz alternating electric field, certified experimental equipment was used. The study material
was the upper jaw tissue. Histological and histochemical staining methods were used. Morphometric study was conducted.
Results: Complex morphological study on the experimental material allowed identifying the damaging effect of low-frequency electromagnetic radiation on the structural
components of tooth and periodontal tissues.
Conclusions: Our findings suggest that the workers who are exposed to occupational low-frequency electromagnetic radiation should be included in the risk group for developing
diseases of the dentomandibular system in order to carry out timely therapeutic and preventive measures.
FEATURES OF CLINICAL MANIFESTATIONS OF DISEASE AND PSYCHOLOGICAL STATUS OF ADOLESCENTS WITH BRONCHIAL ASTHMA OF VARIOUS LEVELS OF CONTROL AND THE INFLUENCE OF RISK FACTORS
Authors: Protsiuk Tetiana L. , Yablon Olga S. , Protsiuk Liudmyla O. , Bykovska Olga A. , Herasymova Оlena V. , Kapitan Tetiana V.
Published: October 2020

Introduction: The problem of psycho-emotional state of patients with asthma is of great importance from a mental and social point of view.
The aim: To find out the factors which influence mental state of adolescents, to determine features of clinical manifestations and of mental status in patients with bronchial
asthma, depending on degree of its control.
Materials and methods: 108 adolescents aged 11-17, ill with BA, of various levels of control. Luscher color test was used to determine the child’s mental status. Anxiety score was
assessed by Spielberger-Hanin State-Trait Anxiety Inventory. Depressive status and depression severity were evaluated by HDRS.
Results: The patients with UC BA reported unsatisfactory living conditions significantly more often compared to those with C BA and the children with PC BA compared to those
with C BA (р<0.01). Patients with PC BA and UC BA were found to have significantly increased proneness to conflict, marked emotional tension and lability, mood swings,
increased anxiety, vulnerability and sensitivity, as compared to those with C BA. Significantly lower state anxiety was revealed in the patients with C BA as compared to those with
PC BA (p = 0.004) and UC BA (p = 0.0001). Significantly lower mean values of depression values were detected in the patients with C BA compared to those with UC BA (p=0.011)
and PC BA (p=0.0015).
Conclusions: The major factors influencing the psychological status of adolescents were: unsatisfactory living conditions, psychic and physical punishment, stress, heavy
workload etc. The patients with BA developed psychological disorders under the influence of those factors.
ON THE ISSUE OF ACCELERATED HYGIENIC ASSESSMENT OF ENVIRONMENTAL GENOTOXIC CARCINOGENS
Authors: Ostash Olga , Shvager Oksana , Grygorenko Liudmyla , Stepanchuk Svetlana , Balenko Nina , Chernychenko Igor
Published: October 2020

The aim of the work was assessment of the criterial significance of the complex of early immunological reactions of the organism, pathomorphological and genotoxic changes
in the organs for the acceleration of testing and hygienic assessment of carcinogenic danger of chemical substances.
Materials and methods: Investigations were carried out in the chronic experiment on white random-bred male mice and included 2 series of the investigations: 1 – application
of benz(a)pyrene on skin in different doses (10.5μg; 2.1μg; 0.21μg); 2 - peroral administration of benz(a)pyrene and phenol (single dose - 0.1 mg). Genotoxic changes in skin
and forestomach were assessed with the help of micronuclear test.
Results: Under carcinogen exposure, regardless of routes of administration we determined an increase frequency of the cells with micronuclei and suppression of T-link of
immune system during the first month which were characterized by a parallelism of development, unidirectional relative to carcinogenesis and presence of reliable reverse
correlative connection between them. In the period between the 1t and the 3d months we observed a stabilization of the number of cells with micronuclei and deepening of
immunosuppression at the expense of the suppression of humoral chain of the immunity.
Conclusions: The obtained data became a basis for the development of methodic scheme of accelerated testing of the chemical substances under investigations for carcinogenicity
and hygienic setting of genotoxic carcinogens.
MEDICAL ERROR AND LIABILITY FOR IT IN SOME POST-SOVIET COUNTRIES (BELARUS, KAZAKHSTAN, MOLDOVA, UKRAINE)
Authors: Gornostay Alesia , Ivantsova Alona , Mykhailichenko Tetiana
Published: October 2020

Introduction: Infliction of harm to life and health due to medical errors is common for the whole world and post-Soviet countries, in particular. The problem of these errors
is one of the most important in medical law, although there is no unified concept of it. A small number of sentences in cases of criminal negligence of medical professionals
indicates a high latency and often unprovability of this crime in a number of post-Soviet countries.
The aim: To disclose the objective and subjective prerequisites of a medical error, reasons for its occurrence, to establish the grounds for criminal liability of medical professionals in case they commit an error and to examine the judicial practice in this regard. Also, to define the concept and types of circumstances exempting criminal liability and their impact on criminal liability issues concerning medical professionals.
Materials and methods: The study is based on the Belarusian, Kazakh, Moldavian and Ukrainian statutory acts as well as international acts, the European Convention for
the Protection of Human Rights and Fundamental Freedoms, case law of the European Court of Human Rights (ECHR), national court judgments. Such methods as dialectical,
comparative, analytic, synthetic and comprehensive have been used in the paper.
Review: On the basis of the study, it has been established that there is no unified concept of a medical error, medical personnel are fairly brought to criminal liability only if they commit an unjustifiable error in the presence of all the mandatory elements of a crime provided for in the relevant article of the Criminal Code. At the same time, it is extremely difficult to prove existence of such an error. Besides, at the state levels, causes and mechanisms of occurring errors have not been revealed, they are not even discussed, which makes it impossible to outline measures to prevent them or reduce their frequency and degree of danger.
Conclusions: The struggle against medical errors should encompass a number of such activities as standardization of clinical treatment protocols, further education of medical professionals and lawyers in regard to patient safety, thorough investigation of each incident in order to exclude a justifiable error or circumstances exempting criminal liability. Equitable, severe and uncompromising punishments for perpetrators should be an effective means preventing commission of crimes in medicine.
PRIMARY AND SECONDARY THROMBOPHILIА: PATHOGENESIS, CLINICAL PRESENTATION, APPROACHES TO THROMBOTIC COMPLICATIONS PREVENTION AND TREATMENT
Authors: Bereziuk Olha M. , Mazur Julia V. , Berko Galyna K. , Perebetiuk Larysa S. , Velychkovych Maryna M. , Temna Olena V. , Movchan Halyna O.
Published: October 2020

Introduction: Thrombophiliа is a predisposition to arterial or venous thrombotic complications as a result of congenital or acquired hemostatic system defects. Thrombophilia increases risk of fatal complications, disability of patients. The assessment of the risk of thrombotic complications makes it possible to prescribe adequate primary or secondary prophylaxis. However, there is no systematic information about estimation risk of thrombosis in various types of thrombophilia and conduction primary and secondary prophylaxis of thrombotic complications, choosing treatment.
The aim: Analysis and arrangement information regarding pathogenesis, clinical features, approaches to diagnosis, risk assessment, primary and secondary prevention and peculiarities of thrombotic complications treatment in patients with thrombophilia.
Materials and methods: There were used methods: content analysis, method of systemic approach. An analysis of the results of clinical trials, the review of articles in the field of hemostasis was conducted.
Conclusions: Patients with deficiency of Pt C, S, antithrombin III deficiency and homozygous factor V Leiden mutation, malignancy, antiphospholipid syndrome, surgical interventions, pregnancy, usage of oral contraceptive pills (OCP s) and hormone replacement therapy (HRT) have the highest risk of thrombotic complications. The type of thrombophilia determinates the choice of anticoagulants, necessity for primary prophylaxis and the duration of secondary prophylaxis.
PHYSICAL INDICES OF THE ORAL FLUID IN CHILDREN WITH CARIES AND INTACT TEETH AT DIFFERENT AGE PERIODS
Authors: Кaskova Lyudmila F. , Маndziuk Тetyana B. , Ulasevych Larissa P. , Kuzniak Natallia B.
Published: October 2020

Introduction: Caries occurs most frequently among dental diseases of the hard dental tissues in children. Its occurrence and intensity do not decrease, although scientists and practitioners make much efforts directed to the reduction of these indices
The aim: Therefore, the objective of our study was to investigate the indices of rate salivation and viscosity of the oral fluid in children at different age periods with caries
and intact teeth.
Materials and methods: 134 children, 7-9 years old, and 89 children,10-12 years old, studying at Poltava schools were examined. Dental examination was conducted according to the common methods. Caries intensity in all the children was determined by Caries Filling Extraction (CFE) Index, and CFE+cfe. To determine salivation rate the oral fluid was collected on empty stomach in the morning into sterile calibrated tubes during 5 minutes.
Results and conclusions: Investigations of physical indices of the oral fluid in children of 7-9 and 10-12 years of age did not find their reliable difference considering the
child’s age. Meanwhile the indices of salivation rate and oral fluid viscosity in children with caries and without it were found to differ much. That is, the course of carious process in children is associated with reduced salivation rate and increased index of the oral fluid viscosity, which in its turn deteriorates hygienic state of the oral cavity enabling to activate the activity of dental deposit microflora and its effect on enamel demineralization followed by occurrence of carious defect of temporary and especially permanent teeth recently erupted and poorly mineralized. The results obtained were calculated by variation statistics method. The indices were considered to be reliable with р≤0,05.
PECULIARITIES OF THE INTERACTION OF THE INDICATORS OF PSYCHOPHYSIOLOGICAL ADAPTATION OF MODERN STUDENTS IN THE CONTEXT OF THE EFFECTIVE MONITORING OF INDIVIDUAL HEALTH OF YOUNG WOMEN AND YOUNG MEN
Authors: Makarov Serhii Y. , Stoyan Nataliya V. , Serheta Ihor V. , Taran Oksana A. , Dyakova Oksana V.
Published: October 2020

Introduction: Creation of modern information systems for supervision of the state of health of the population is impossible without effective monitoring of the state of
individual health, the implementation of a comprehensive assessment of risk factors and the development of recommendations for the preservation of the health of individuals.
The aim: Determination of the peculiarities of the interaction between the indicators of the psychophysiological adaptation of students during the асademic year and throughout the period of stay in a higher medical education institution in the context of providing effective monitoring of the individual health of young women and young men.
Materials and methods: A set of psychophysiological functions of the organism of the students was investigated by instrumental techniques and computer diagnostic complex “Effecton Studio”, applying of standardized t questionnaires the characteristics of the person were determined, and the prognostic evaluation of the obtained data was carried out with factor analysis procedures.
Results: It was determined that the following factors should be noted as the main factor formations during the analysis of the physiologically-determined correlates of processes psychophysiological adaptation: peculiarities of dynamic performance, balance of nervous processes and mobility of nerve processes, and mentally-determined correlates of processes psychophysiological adaptation: peculiarities of temperament and anxiety, character properties, level of subjective control of personality, aggressive manifestations of personality and emotional burnout.
Conclusions: In the study were determined the most peculiarities of the interaction of the indicators of psychophysiological adaptation of modern students in the context of
providing efficient monitoring of individual health.
ANALYSIS OF THE MORTALITY RATE AMONG THE POPULATION OF THE POLTAVA REGION AND THE WAYS OF ITS REDUCTION
Authors: Dvornyk Valentyn M. , Bielikova Inna V. , Shylkina Ludmyla M. , Filatova Valentyna L. , Martynenko Natalia M.
Published: October 2020

Introduction: Saving and improvement of population’ health is one of the main priorities of the policy in any country. Studying of the level and causes of mortality is a powerful tool for assessing the effectiveness of health care systems. WHO recommends using of the European classification of preventable causes of death that based on three levels of prevention.
The aim of this study is to compare the level and structure of mortality of the population of Ukraine and the Poltava region, to substantiate scientific approaches to the study
and identification of those causes of death that can be prevented in order to formulate prevention programs at different level.
Materials and methods: In research are used the information from the State Statistics Service of Ukraine and from the Center for Medical Statistics of the MoH of Ukraine.
Review: Despite the positive dynamics of mortality in recent years, both in the Poltava region and in Ukraine, the indicators remain extremely negative. About 73.3% of all
fatalities in Ukraine are three main types of causes cardiovascular diseases, external causes of death and neoplasms. In the Poltava region, 70.56% of all causes of death are due to cardiovascular disease; neoplasms occupy 13.88%; external causes - 4.87%; diseases of the digestive system - 3,06%; respiratory diseases - 1.31% of the causes of death.
Conclusions: The mortality rate both in the Poltava region and in Ukraine has tendency for declines, but remains rather high. General trends in the structure of causes of death: in the first place are diseases of the cardiovascular system, the second - neoplasms, the third -external causes. Structuring of the causes of death that based on the principle of prevention in Ukraine do not conduct.
LUBNY PHARMACY AS A FOUNDATING STRUCTURE OF MILITARY FARMACY IN UKRAINE
Authors: Hrynzovska Anastasiia A. , Holovanova Iryna A. , Hrynzovskyi Anatolii M.
Published: October 2020

Introduction: Military pharmacy has always been a priority, being widely supported by the state with any social order. Field pharmacy development has always been considered a national safety factor. After creation of the numerous military commands and improvement of medical conditions relating to preserving and restoring the military men health, the importance of development of pharmacy as a science has only been increasing. The object of the study in this article is development of Ukrainian pharmacy as illustrated by the Poltava region example.
The aim: The study is research of the pharmacy development and its influence on to the neighbor fields within the Poltava region.
Material and methods: systemic approach, historical and dialectical methods, methods of theoretical and empirical learning.
Conclusions: The Lubny pharmacy was the basis for the military pharmaceutical service in Ukraine and triggered foundation of private pharmacies in the Poltava region. Also, the Lubny pharmacy had effected on the development of pharmaceutical service and industrial agricultural cultivation of medical plants in Ukraine.
PROGNOSTIC PARAMETERS OF THE SUSCEPTIBILITY OF STAPHYLOCOCCUS SPP. TO AMINOGLYCOSIDES AND DOXYCYCLINE
Authors: Nazarchuk Oleksandr A. , Nahaichuk Vasyl I. , Osadchuk Neonila I. , Dmytriiev Dmytro V. , Dmytriiev Kostiantyn D. , Turzhanska Oksana S.
Published: October 2020

The aim: To perform microbiological investigation and analytic mathematic prediction of clinical isolates of S. aureus to aminoglycosides in patients with severe burns.
Materials and methods: We analyzed resistance of 199 S. aureus strains to aminoglycosides (gentamicin, tobramycin and amikacin) and doxycycline from 435 patients treated
in the regional hospital due to burns for the period from 2011-2017.
Results: We created predictive curves for the prediction of susceptibility of S. aureus strains to aminoglycosides and doxycycline based on the changes in S. aureus resistance during the years of observation and expressed in mathematic equations. Susceptibility of S. aureus to gentamicin was 42.86 % at the end of observation and will decline in future. Despite tobramycin was efficient against 72.86 % of strains in 2017, mathematic modeling indicates rapid decline in its efficacy in future. Efficacy of amikacin was dropping during the last years, but according to the equation it efficacy will increase over 60 % in 2018. S. aureus susceptibility to doxycycline was 65.38 % in 2017 and mathematic
modeling indicates its gradual decline in the nearest future.
Conclusions: Predicitive values of S. aureus susceptibility indicates not sufficient efficacy of these drugs in patients with infectious complications of burns. Tendency of the slight decline of S. aureus susceptibility to doxycycline still indicates sufficient levels of its efficacy in the nearest future. This justify its use as a second-line therapy with the causative agent in patients with burns.
APOPTOTIC PROCESSES’ RESEARCH ON THE MODEL OF TYPE 2 DIABETES MELLITUS ON OBESITY’S BACKGROUND UNDER THE INFLUENCE OF DENSE BEAN EXTRACT
Authors: Rybak Viktoria A. , Korol Viktoria V. , Derkach Natalia V.
Published: October 2020

The aim of the study was to observe the influence of dense bean extract on the intensity of apoptotic processes in the liver cells and pancreas of rats on a model of type 2
diabetes mellitus on obesity’s background.
Materials and methods: The main method was to model type 2 diabetes mellitus on the background of obesity in organism of mature six-month-old male rats of the Wistar
population (n = 21), weighing 150-170 g. The modelling was carried out by intraperitoneal low dose administration of streptozotocin (30 mg / kg, in citrate buffer pH = 4, 5)
inside after three months period of keeping animals on a combined diet. Apoptosis in DNA samples of liver and pancreas cells was identified in duplicates using electrophoresis
in a 1% agarose gel with using a 1kb DNA SibEnzyme apoptosis marker (from 10,000 to 250 nucleotides).
Results: Only in two of the seven studied DNA samples of the pancreas of a group of rats, treated with a dense bean extract, were observed the traces of necrosis without
detectable manifestations of the apoptotic process. It situates at the level of indicators of the animals’ intact control group and indicates the distinct effect’s presence which
includes maintaining pancreas cells survival (in both endocrine and exocrine parts) if imbalance of carbohydrate and lipid metabolism take place in organism.
Conclusion: Dense bean extract showed a more distinct effect than the comparison drug metformin in relation to the risk of premature loss of pancreatic cell function and
the development of non-alcoholic fatty liver disease. A dense bean extract is promising for further pharmacological studies, with the aim of creating phytopreparations –
«Glyphasonorm» tablets and «Glyfasolin» capsules for the correction of type 2 diabetes mellitus and its complications.
NITRIC OXIDE METABOLISM IN PATIENTS WITH COMMUNITYACQUIRED PNEUMONIA ASSOCIATED WITH CORONARY HEART DISEASE AND THE POSSIBILITY OF ITS MEDICAMENTOUS MANAGEMENT
Authors: Ostrovskyy Mykola M. , Varunkiv Oleksandr I. , Todoriko Lilia Dm. , Savelikhina Iryna O. , Kulynych-Miskiv Mariana O. , Zuban Alla B. , Molodovets Olha B. , Ostrovska Kseniia M.
Published: October 2020

The aim: To assess the metabolic by-products of nitric oxide in peripheral blood before and after the medicamentous management in patients suffering from community-acquired pneumonia associated with coronary heart disease. Materials and methods: We have examined 102 patients with community-acquired pneumonia aged from 50 to 65 years, of which 58 patients were diagnosed with coronary heart disease (CHD). The complex treatment of patients with coronary heart disease was supplemented by the additional use of tivortin aspartate, which was taken orally with food at the dose of 5 ml (1g) 3 times a day for 15 days. The NO content in blood plasma was assessed by the concentration of the amount of final NO metabolites (NO3 + NO2), identified by means of the photocalorimetric method. Results: The content of (NO3 + NO2) in peripheral blood of patients with CAP was slightly higher (6.83 ± 0.29) μmol/l as compared to the group of apparently healthy individuals (5.19 ± 0.14) μmol/l, while in patients with CAP associated with CHD it has markedly increased to (12.74 ± 1.09) μmol/l. Against the background of administered treatment, the index of (NO3 + NO2) in patients with coronary heart disease has decreased to (5.76 ± 0.33) μmol/l, while in the group of patients who were not given tivortin aspartate additionally, this index has even slightly increased (7.01 ± 0.40) μmol/l. Conclusions: Marked increase of (NO3 + NO2) levels in blood pointed to destabilization of the course of coronary heart disease with CAP, which was eliminated by the involvement of tivortin aspartate (15 days) to the main course of treatment.