bluuebunny/crossref_metadata_2025 huggingface dataset:
Trafficking Processes and Secretion Pathways Underlying the Formation of Plant Cuticles
Authors: Philippe Glenn , De Bellis Damien , Rose Jocelyn K. C. , Nawrath Christiane
Published: January 2022

Cuticles are specialized cell wall structures that form at the surface of terrestrial plant organs. They are largely comprised lipidic compounds and are deposited in the apoplast, external to the polysaccharide-rich primary wall, creating a barrier to diffusion of water and solutes, as well as to environmental factors. The predominant cuticle component is cutin, a polyester that is assembled as a complex matrix, within and on the surface of which aliphatic and aromatic wax molecules accumulate, further modifying its properties. To reach the point of cuticle assembly the different acyl lipid-containing components are first exported from the cell across the plasma membrane and then traffic across the polysaccharide wall. The export of cutin precursors and waxes from the cell is known to involve plasma membrane-localized ATP-binding cassette (ABC) transporters; however, other secretion mechanisms may also contribute. Indeed, extracellular vesiculo-tubular structures have recently been reported in Arabidopsis thaliana (Arabidopsis) to be associated with the deposition of suberin, a polyester that is structurally closely related to cutin. Intriguingly, similar membranous structures have been observed in leaves and petals of Arabidopsis, although in lower numbers, but no close association with cutin formation has been identified. The possibility of multiple export mechanisms for cuticular components acting in parallel will be discussed, together with proposals for how cuticle precursors may traverse the polysaccharide cell wall before their assimilation into the cuticle macromolecular architecture.
Environmental Controls on Multi-Scale Dynamics of Net Carbon Dioxide Exchange From an Alpine Peatland on the Eastern Qinghai-Tibet Plateau
Authors: Yao Hu , Peng Haijun , Hong Bing , Guo Qian , Ding Hanwei , Hong Yetang , Zhu Yongxuan , Cai Cheng , Chi Jinshu
Published: January 2022

Peatlands are characterized by their large carbon storage capacity and play an essential role in the global carbon cycle. However, the future of the carbon stored in peatland ecosystems under a changing climate remains unclear. In this study, based on the eddy covariance technique, we investigated the net ecosystem CO2 exchange (NEE) and its controlling factors of the Hongyuan peatland, which is a part of the Ruoergai peatland on the eastern Qinghai-Tibet Plateau (QTP). Our results show that the Hongyuan alpine peatland was a CO2 sink with an annual NEE of −226.61 and −185.35 g C m–2 in 2014 and 2015, respectively. While, the non-growing season NEE was 53.35 and 75.08 g C m–2 in 2014 and 2015, suggesting that non-growing seasons carbon emissions should not be neglected. Clear diurnal variation in NEE was observed during the observation period, with the maximum CO2 uptake appearing at 12:30 (Beijing time, UTC+8). The Q10 value of the non-growing season in 2014 and 2015 was significantly higher than that in the growing season, which suggested that the CO2 flux in the non-growing season was more sensitive to warming than that in the growing season. We investigated the multi-scale temporal variations in NEE during the growing season using wavelet analysis. On daily timescales, photosynthetically active radiation was the primary driver of NEE. Seasonal variation in NEE was mainly driven by soil temperature. The amount of precipitation was more responsible for annual variation of NEE. The increasing number of precipitation event was associated with increasing annual carbon uptake. This study highlights the need for continuous eddy covariance measurements and time series analysis approaches to deepen our understanding of the temporal variability in NEE and multi-scale correlation between NEE and environmental factors.
Functional Divergence of G and Its Homologous Genes for Green Pigmentation in Soybean Seeds
Authors: Tokumitsu Yusuke , Kozu Takuto , Yamatani Hiroshi , Ito Takeshi , Nakano Haruna , Hase Ayaka , Sasada Hiroki , Takada Yoshitake , Kaga Akito , Ishimoto Masao , Kusaba Makoto , Nakashima Taiken , Abe Jun , Yamada Tetsuya
Published: January 2022

The degradation of chlorophyll in mature soybean seeds is closely related to the development of their yellow color. In this study, we examined G, its homologue G-like (GL), and their mutant alleles and investigated the relationship between these genes and chlorophyll accumulation in the seed coats of mature seeds. Transient expression of G and GL proteins fused with green fluorescent protein revealed that both were localized in plastids. Overexpression of G resulted in the accumulation of chlorophyll in the seed coats and cotyledons of mature seeds, indicating that high expression levels of G result in chlorophyll accumulation that exceeds its metabolism in the seeds of yellow soybean. Analysis of near isogenic lines at the G locus demonstrated a significant difference in the chlorophyll content of the seed coats and cotyledons of mature seeds when G and mutant g alleles were expressed in the d1d2 stay-green genetic background, indicating that the G protein might repress the SGR-independent degradation of chlorophyll. We examined the distribution of mutant alleles at the G and GL loci among cultivated and wild soybean germplasm. The g allele was widely distributed in cultivated soybean germplasm, except for green seed coat soybean lines, all of which contained the G allele. The gl alleles were much fewer in number than the g alleles and were mainly distributed in the genetic resources of cultivated soybean from Japan. None of the landraces and breeding lines investigated in this study were observed to contain both the g and gl alleles. Therefore, in conclusion, the mutation of the G locus alone is essential for establishing yellow soybeans, which are major current soybean breeding lines.
Adaptive Mechanisms Make Lupin a Choice Crop for Acidic Soils Affected by Aluminum Toxicity
Authors: Quiñones Miguel A. , Lucas M. Mercedes , Pueyo José J.
Published: January 2022

Almost half of the world’s agricultural soils are acidic, and most of them present significant levels of aluminum (Al) contamination, with Al3+ as the prevailing phytotoxic species. Lupin is a protein crop that is considered as an optimal alternative to soybean cultivation in cold climates. Lupins establish symbiosis with certain soil bacteria, collectively known as rhizobia, which are capable of fixing atmospheric nitrogen. Moreover, some lupin species, especially white lupin, form cluster roots, bottlebrush-like structures specialized in the mobilization and uptake of nutrients in poor soils. Cluster roots are also induced by Al toxicity. They exude phenolic compounds and organic acids that chelate Al to form non-phytotoxic complexes in the rhizosphere and inside the root cells, where Al complexes are accumulated in the vacuole. Lupins flourish in highly acidic soils where most crops, including other legumes, are unable to grow. Some lupin response mechanisms to Al toxicity are common to other plants, but lupin presents specific tolerance mechanisms, partly as a result of the formation of cluster roots. Al-induced lupin organic acid secretion differs from P-induced secretion, and organic acid transporters functions differ from those in other legumes. Additionally, symbiotic rhizobia can contribute to Al detoxification. After revising the existing knowledge on lupin distinct Al tolerance mechanisms, we conclude that further research is required to elucidate the specific organic acid secretion and Al accumulation mechanisms in this unique legume, but definitely, white lupin arises as a choice crop for cultivation in Al-rich acidic soils in temperate climate regions.
Current Approaches, Typologies and Predictors of Deviant Work Behaviors: A Scoping Review of Reviews
Authors: Zappalà Salvatore , Sbaa Maha Yomn , Kamneva Elena V. , Zhigun Leonid A. , Korobanova Zhanna V. , Chub Anna A.
Published: January 2022

This study provides a scoping review of the recent conceptual developments about the deviant work behavior and counterproductive work behavior constructs. It also examines the specific types of deviant work behavior that have been more consistently investigated in the last decade, and whether they cover the interpersonal or organizational type of deviant behavior. In addition, individual, group, and organizational predictors of deviant work behaviors are examined. A scoping review of reviews was conducted on Scopus and Web of Science databases and 54 studies published from 2010 to June 2021 were taken into account. Results show that more recent conceptualizations are based on well established models in the literature and consider the hierarchical structure of these two constructs. Recent reviews examine the relationships of deviant work behavior with job performance and ethical behavior constructs, the multilevel nature of deviant work behavior, and the consequences for the actor of the deviance. The specific types of deviant work behavior more frequently reviewed in the last decade are workplace abuse, incivility, ostracism, bullying and sexual harassment, and abusive and destructive leadership; this evidence suggests a much greater attention to interpersonal, rather than organizational, forms of deviant work behavior. Regarding antecedents, results show the continuing prevalence of personality factors antecedents. Limitations of the study and theoretical and practical implications for the field are also provided.
Gender, Socioeconomic Status, Cultural Differences, Education, Family Size and Procrastination: A Sociodemographic Meta-Analysis
Authors: Lu Desheng , He Yiheng , Tan Yu
Published: January 2022

Procrastination describes a ubiquitous scenario in which individuals voluntarily postpone scheduled activities at the expense of adverse consequences. Steel (2007) pioneered a meta-analysis to explicitly reveal the nature of procrastination and sparked intensive research on its demographic characteristics. However, conflicting and heterogeneous findings reported in the existing literature make it difficult to draw reliable conclusions. In addition, there is still room to further investigate on more sociodemographic features that include socioeconomic status, cultural differences and procrastination education. To this end, we performed quantitative sociodemographic meta-analyses (k = 193, total n = 106,764) to fill this gap. It was found that the general tendency and academic procrastination tendency of males were stronger than females (r = 0.04, 95% CI: 0.02–0.05). No significant effects of differences in socioeconomic status (i.e., poor or rich), multiculturalism (i.e., Han nation or minorities), nationality (i.e., China or other countries), family size (i.e., one child or > 1 child), and educational background (i.e., science or arts/literature) were found to affect procrastination tendencies. Furthermore, it was noteworthy that the gender differences in procrastination tendencies were prominently moderated by measurements, which has a greater effect on the Aitken Procrastination Inventory (API) (r = 0.035, 95% CI: −0.01–0.08) than on the General Procrastination Scale (GPS) (r = 0.018, 95% CI: −0.01–0.05). In conclusion, this study provides robust evidence that males tended to procrastinate more than females in general and academic profiles, and further indicates that procrastination tendencies do not vary based on sociodemographic situations, including socioeconomic status, multiculturalism, nationality, family size, and educational background.
Examining the Effectiveness and Efficiency of an Innovative Achievement Goal Measurement for Preschoolers
Authors: Wu Chung Chin
Published: January 2022

A large number of studies have investigated achievement goals and their related antecedents and consequences above elementary school level. However, few studies have implemented achievement goal assessment to investigate achievement goals and their relevance for preschoolers. In particular, no valid measurement has been developed for preschoolers’ self-reporting of their achievement goals. The main purposes of this study were twofold: (1) To develop an innovative achievement goal measurement for preschoolers, and to investigate the best theoretical model for understanding preschoolers’ achievement goal across gender. (2) To examine the effectiveness and efficiency of the pictorial and pure text measurement format and approaches (for young children’s self-reporting and teachers’ rating purposes, respectively). A total of 364 preschoolers aged 5 years participated in self-report activity, and 32 preschool teachers obtained consent to rate 193 out of 364 preschoolers. Results showed: (1) the developed achievement goal measurement was a valid tool for understanding preschoolers’ achievement goals and was equally suitable for boys and girls. (2) The 6-factor achievement goal model was the best theoretical perspective for understanding preschoolers’ achievement goals for both boys and girls. (3) The pictorial measurement format for preschoolers’ self-reporting of achievement goals was a more effective but less efficient way to investigate preschoolers’ achievement goals, while the opposite was the case for the pure text measurement format for teachers’ ratings. Implications for achievement goal literature and future research are discussed.
Design My Music Instrument: A Project-Based Science, Technology, Engineering, Arts, and Mathematics Program on The Development of Creativity
Authors: Cheng Li , Wang Meiling , Chen Yanru , Niu Weihua , Hong Mengfei , Zhu Yuhong
Published: January 2022

Creativity is an essential factor in ensuring the sustainable development of a society. Improving students’ creativity has gained much attention in education, especially in Science, Technology, Engineering, Arts, and Mathematics (STEAM) education. In a quasi-experimental design, this study examines the effectiveness of a project-based STEAM program on the development of creativity in Chinese elementary school science education. We selected two fourth-graders classes. One received a project-based STEAM program (the experimental group, n = 33), and the other received a conventional science teaching (the control group, n = 33) over 6 weeks. Students’ creativity was assessed before and after the intervention using a multi-method approach, including a test of divergent thinking, a story completion through the Consensus Assessment Technique (CAT), a creative self-efficacy (CSE) measure, and a group-based creative project. Moreover, all students received a test of their science knowledge after the intervention. The results showed that compared with the control group, the creativity of the experimental group students improved significantly for 6 weeks at both individual and group level, even though their knowledge in science were comparable. This result confirmed the effectiveness of a project-based STEAM educational program improving elementary school students’ creativity. Implications are discussed.
Stronger Prejudices Are Associated With Decreased Model-Based Control
Authors: Sebold Miriam , Chen Hao , Önal Aleyna , Kuitunen-Paul Sören , Mojtahedzadeh Negin , Garbusow Maria , Nebe Stephan , Wittchen Hans-Ulrich , Huys Quentin J. M. , Schlagenhauf Florian , Rapp Michael A. , Smolka Michael N. , Heinz Andreas
Published: January 2022

Background:Prejudices against minorities can be understood as habitually negative evaluations that are kept in spite of evidence to the contrary. Therefore, individuals with strong prejudices might be dominated by habitual or “automatic” reactions at the expense of more controlled reactions. Computational theories suggest individual differences in the balance between habitual/model-free and deliberative/model-based decision-making.

Methods:127 subjects performed the two Step task and completed the blatant and subtle prejudice scale.

Results:By using analyses of choices and reaction times in combination with computational modeling, subjects with stronger blatant prejudices showed a shift away from model-based control. There was no association between these decision-making processes and subtle prejudices.

Conclusion:These results support the idea that blatant prejudices toward minorities are related to a relative dominance of habitual decision-making. This finding has important implications for developing interventions that target to change prejudices across societies.
Support for Conciliatory Policies in the Israeli-Palestinian Conflict: The Role of Different Modes of Identification and Territorial Ownership Perceptions
Authors: Storz Nora , Martinović Borja , Rosler Nimrod
Published: January 2022

Understanding people’s attitudes toward conciliatory policies in territorial interethnic conflicts is important for a peaceful conflict resolution. We argue that ingroup identification in combination with the largely understudied territorial ownership perceptions can help us explain attitudes toward conciliatory policies. We consider two different aspects of ingroup identification—attachment to one’s ethnic ingroup as well as ingroup superiority. Furthermore, we suggest that perceptions of ingroup and outgroup ownership of the territory can serve as important mechanisms that link the different forms of ingroup identification with conciliatory policies. In the context of the Israeli-Palestinian conflict, among Israeli Jews (N= 1,268), we found that ingroup superiority, but not attachment, was negatively related to conciliatory policies. This relationship was explained by lower outgroup (but not by higher ingroup) ownership perceptions of the territory. Our findings highlight the relevance of studying ingroup superiority as a particularly relevant dimension of identification that represents a barrier to acknowledging outgroup’s territorial ownership, and is thus indirectly related to less support for conciliatory policies in intergroup conflict settings.
When and How Workplace Helping Promotes Deviance? An Actor-Centric Perspective
Authors: Zhang Hao , Lin Chunpei , Lai Xiumei , Liu Xiayi
Published: January 2022

Despite the vast academic interest in workplace helping, little is known about the impact of different types of helping behaviors on physiological and behavioral ramifications of helpers. By taking the actor-centric perspective, this study attempts to investigate the differential impacts of three kinds of helping behaviors (caring, coaching, and substituting helping) on helpers themselves from the theory of resource conservation. To test our model, 512 Chinese employees were surveyed, utilizing a three-wave time-lagged design, and we found that caring and coaching helping were negatively associated with workplace deviance, whereas substituting helping was positively associated with subsequent workplace deviance. Emotional exhaustion mediated the effects of three helping behaviors on subsequent workplace deviance. Moreover, employees' extrinsic career goals influenced the strength of the relationship between three helping behaviors and emotional exhaustion and the indirect effects of three helping behaviors on subsequent workplace deviance via emotional exhaustion. We discuss the implications of our findings for both theories and practices.
Expectations and Experiences With Online Education During the COVID-19 Pandemic in University Students
Authors: Lobos Karla , Cobo-Rendón Rubia , Mella-Norambuena Javier , Maldonado-Trapp Alejandra , Fernández Branada Carolyn , Bruna Jofré Carola
Published: January 2022

Due to COVID-19, university students continued their academic training remotely. To assess the effects of emergency remote teaching (ERT), we evaluated the expectations and, subsequently, the experiences of university students about online education. This study employed a simple prospective design as its method. We assessed the expectations of 1,904 students from different discipline areas (1,106 women and 798 men; age M = 21.56; SD = 3.07) during the beginning of the first semester, March 2020 (T1), and their experiences at the end of the same academic period, September 2020 (T2). We used convenience non-probability sampling. Participants responded to the questionnaire on Expectations toward virtual education in higher education for students and the questionnaire on virtual education experiences in higher education. The results showed that students’ responses reflected low expectations regarding peer relationships and comparison with face-to-face education (T1). This perception was maintained during the evaluation of experiences (T2). Students reported positive experiences regarding online teaching and learning, online assessment, and their self-efficacy beliefs at T2. Statistically significant differences between measurements were found, with the expertise presenting higher averages than expectations. Furthermore, differences by gender were identified, reporting a positive change in the scores of women. In addition, results reflected differences according to the disciplinary area, showing Social Sciences and Medical and Health Sciences students a more significant size effect. Findings regarding the empirical evidence and the implications for future teaching scenarios in Higher Education are discussed.
A Naturalistic, European Multi-Center Clinical Study of Electrodermal Reactivity and Suicide Risk Among Patients With Depression
Authors: Carli Vladimir , Hadlaczky Gergo , Petros Nuhamin Gebrewold , Iosue Miriam , Zeppegno Patrizia , Gramaglia Carla , Amore Mario , Baca-Garcia Enrique , Batra Anil , Cosman Doina , Courtet Philippe , Di Sciascio Guido , Ekstrand Joakim , Galfalvy Hanga , Gusmão Ricardo , Jesus Catarina , Heitor Maria João , Constante Miguel , Rad Pouya Movahed , Saiz Pilar A. , Wojnar Marcin , Sarchiapone Marco
Published: January 2022

Background:Electrodermal hyporeactivity has been proposed as a marker of suicidal risk. The EUDOR-A study investigated the prevalence of electrodermal hyporeactivity among patients with depression and its association with attempted and completed suicide.

Methods:Between August 2014 and March 2016, 1,573 in- and outpatients with a primary diagnosis of depression (active or remission phase) were recruited at 15 European psychiatric centers. Each patient was followed-up for 1 year. Electrodermal activity was assessed at baseline with the ElectroDermal Orienting Reactivity Test. Data on the sociodemographic characteristics, clinical diagnoses, and treatment of the subjects were also collected. The severity of the depressive symptoms was assessed through the Montgomery–Asberg Depression Rating Scale. Information regarding number, time, and method of suicide attempts was gathered at baseline and at the end of the 1-year follow-up. The same data were collected in case of completed suicide.

Results:Hyporeactive patients were shown to be significantly more at risk of suicide attempt compared to reactive patients, both at baseline and follow-up. A sensitivity of 29.86% and a positive predictive value (PPV) of 46.77% were found for attempted suicide at baseline, while a sensitivity of 35.36% and a PPV of 8.92% were found for attempted suicide at follow-up. The sensitivity and PPV for completed suicide were 25.00 and 0.61%, respectively. However, when controlled for suicide attempt at baseline, the association between hyporeactivity and follow-up suicide attempt was no longer significant. The low number of completed suicides did not allow any analysis.
Looking Into Recent Suicide Rates and Trends in Malaysia: A Comparative Analysis
Authors: Lew Bob , Kõlves Kairi , Lester David , Chen Won Sun , Ibrahim Nurashikin bt , Khamal Noor Raihan bt , Mustapha Feisul , Chan Caryn Mei Hsien , Ibrahim Norhayati , Siau Ching Sin , Chan Lai Fong
Published: January 2022

Background:Suicide is a preventable cause of death. Examining suicide rates and trends are important in shaping national suicide prevention strategies. Therefore, the objectives of this study were to analyze age-standardized suicide trends of Malaysia between 2000 and 2019 using the WHO Global Health Estimates data, and to compare the 2019 rate with countries from the Association of South-East Asian Nations (ASEAN), Muslim majority countries, and the Group of Seven (G7).

Methods:The age-standardized suicide rates data were extracted from the WHO Global Health Estimates. We calculated the average age-standardized suicide rates of the last 3 years from 2017 to 2019. Joinpoint regression analysis was conducted to calculate the average annual percentage change (APC) of the age-standardized suicide rates in Malaysia from 2000 to 2019.

Results:Between 2000 and 2019, the minimum and maximum suicide rates for both sexes in Malaysia were 4.9 and 6.1 per 100,000 population respectively, whilst the past 3-year (2017–2019) average rates were 5.6, 8.8, and 2.4 for both sexes, males, and females, respectively. The suicide rates decreased significantly for both sexes between 2000 and 2013. Between 2014 and 2019, the suicide rates increased significantly for males. In 2019, Malaysia recorded the rate of 5.8 per 100,000 population, with an estimated 1,841 suicide deaths, i.e., ~5 deaths per day. The Malaysian suicide rate was the second highest amongst selected Muslim majority countries, in the middle range amongst ASEAN countries, and lower than all G7 countries except Italy.

Conclusions:There is a need to further explore factors contributing to the higher suicide rates among Malaysian males. In light of the rising suicide rates in Malaysia, national mental health and suicide prevention initiatives are discussed and the importance of high-quality suicide surveillance data is emphasized.
Hidden in Plain Sight? Men's Coping Patterns and Psychological Distress Before and During the COVID-19 Pandemic
Authors: Livingston Julianne D. , Youssef George J. , Francis Lauren M. , Greenwood Christopher J. , Olsson Craig A. , Macdonald Jacqui A.
Published: January 2022

Individuals cope with stress using multiple strategies, yet studies of coping profiles are rare. We draw data from a longitudinal study of Australian men (n = 272; 30–37 years), assessed before (T1) and during (T2) a nation-wide COVID-19 lockdown. We aimed to: (1) identify men's multi-strategy coping profiles before and during the pandemic; (2) assess cross-sectional (T1-T1, T2-T2) and prospective (T1-T2) associations between profiles and symptoms of psychological distress (stress, anxiety, depression, and anger); and (3) examine relationships between coping profiles and appraisals of pandemic-related stressors and options for coping. In latent profile analyses of 14 coping strategies, three profiles emerged that were largely consistent across T1 and T2: (1) Relaxed Copers (low use of all strategies), (2) Approach Copers, and (3) Dual Copers (high avoidant and moderate-high approach-oriented strategies). Compared to Relaxed and Approach Copers, men who were Dual Copers had elevated psychological distress cross-sectionally before (T1) and during (T2) the pandemic, but not prospectively. Post hoc analyses suggested this was because many men changed coping profiles in the context of the pandemic. Men with stable (T1-T2) or new (T2 only) Dual Coping profiles experienced greater psychological distress and more negative appraisals of pandemic stressors and options for coping. In sum, at the sample level, the composition of men's coping profiles and associations with mental health risk were relatively stable over time and contexts; however, many men appeared to respond to pandemic conditions by changing coping profile groups, with mostly positive mental health outcomes. Of concern were men who adopted more avoidant strategies (e.g., denial, self-distraction, disengagement, substance use, and self-blame) under pandemic conditions. These Dual Coper men also engaged in commonly observable approach-oriented behaviours (e.g., planning, active coping, humour, seeking practical social support) that may mask their vulnerability to mental health risk. Our findings highlight the clinical importance of enquiring about escalating or frequent avoidant coping even in the presence of more active and interactive approach-oriented behaviours.
The Association Between Dry Eye Disease With Depression, Anxiety and Sleep Disturbance During COVID-19
Authors: He Qing , Chen Zhuo , Xie Caiyuan , Liu Lin , Wei Ruihua
Published: January 2022

Objective: This study aimed to investigate the relationship between dry eye disease (DED) with anxiety and depression. Additionally, the mediating effect of sleep quality on this relationship was explored.

Methods: 321 patients with DED were recruited from Tianjin Medical University Eye Hospital clinic and surveyed using demographic questionnaires, the Ocular Surface Disease Index (OSDI), Hospital Anxiety and Depression Scale (HADS), and Pittsburgh Sleep Quality Index (PSQI). Regression analysis and the bootstrap method were used to investigate the influence of sleep on the relationship between DED, anxiety and depression.

Results: Among the patients with DED, 86 (26.79%), 85 (26.48%), and 54 (16.82%) patients presented with anxiety, depression, and both anxiety and depression respectively. The OSDI and PSQI score were positively correlated with depression and anxiety (all p < 0.01). The direct effects of OSDI on depression and anxiety were significant (P < 0.01). Additionally, the bootstrap test showed significant mediating effects of subjective sleep quality [95% CI [0.003–0.016] (depression); [0.001–0.011] (anxiety)] and sleep latency [95% CI [0.001–0.010] (depression); [0.001–0.008] (anxiety)]. These results indicated that the severity of DED symptoms, as measured by the OSDI score, affected anxiety and depression through a direct and an indirect pathway mediated by subjective sleep quality and sleep latency.

Conclusions: The results indicated that there was a significant correlation between DED and anxiety and depression. Moreover, subjective sleep quality and sleep latency were a mediator of the relationship between DED symptoms and anxiety and depression.
Hyperfocus: The ADHD Superpower
Authors: Hupfeld Kathleen E. , Abagis Tessa R. , Osborne Jahla B. , Tran Quynh T. , Shah Priti
Published: January 2022

Imagine playing a video game that is so fun you do not realize someone is calling your name. Everyone can probably think of a time like that—when you were so focused that you did not notice things happening around you. For some people, this feeling of deep attention, called hyperfocus, happens really often. In our research, we first developed a way to measure hyperfocus. Next, we tested whether people with attention-deficit/hyperactivity disorder (ADHD) hyperfocus more often. ADHD is a condition that can make it harder to pay attention to things. Despite this, many people with ADHD say that they often hyperfocus. We found that people with ADHD do have higher hyperfocus levels. In this article, we talk about our hyperfocus research, how hyperfocus can be an ADHD superpower, and our next steps toward better understanding hyperfocus and how to harness it.
Preliminary Outbreak Investigation and Spatial Epidemiology of Rabbit Hemorrhagic Disease Outbreak in Nigeria
Authors: Oyewo Muftau , Al-Mustapha Ahmad I. , Richards Bukola A. , Abdulkareem Lateefah , Olasoju Taiwo , Babale Sufiyan M. , Khalid Hamza , Meseko Clement , Balogun Muhammad S.
Published: January 2022

The outbreak of highly contagious transboundary rabbit hemorrhagic disease (RHD) in Nigeria has a severe socio-economic impact on the rabbit industry. We present the outbreak investigation and spatial epidemiology of the first confirmed RHD outbreak in Nigeria from a field survey of 28 stochastic outbreaks in Kwara State, north-central Nigeria. A total of 1,639 rabbits died from 2,053 susceptible rabbits. The serotype “RHDV-2” was detected in tissue samples from some of the outbreaks. The case fatality rate of the RHDV-2 outbreak was 79.8%. The source of the outbreak is still unknown. Most (71.4%) of the farmers had introduced new rabbits into their farms 1–2 weeks before the outbreak. Most of the farmers practiced biosecurity measures such as farm fencing (83.1%) and routine disinfection of the farm materials (53.6%). However, only 17.8% of the farmers enforced movement restrictions into their farms. Some of the farmers (42.8%) had restocked their farms after being affected by the RHD outbreak and 75% of all those farmers that have restocked had used the RHD vaccine. There was no statistically significant association between adherence to biosecurity measures and the RHD outbreak in affected farms (p = 0.408). However, the introduction of new rabbits into rabbit farms significantly pre-disposed farms to the RHD outbreak (p < 0.001). There is a need for active surveillance of RHD across the country to ensure efficient and effective tracking, monitoring, and control of the disease. Equally, understanding the genetic diversity of the Lagoviruses in Nigeria that cause RHD to aid vaccine development is of utmost importance to prevent future RHD outbreaks.
Slovenian Pet Owners' Experience, Attitudes, and Predictors Regarding Cannabinoid Use in Dogs and Cats
Authors: Tomsič Katerina , Rakinić Kristina , Seliškar Alenka
Published: January 2022

The aim of this study was to assess the personal experience and attitudes of Slovenian pet owners regarding cannabinoid (CBD) use and to identify the predictors of the first use and reuse of CBDs in dogs and cats. We hypothesized that positive attitudes toward CBDs, postmodern health values, and personal experience would be significant predictors of CBD use in animals. An open online survey targeted randomly selected Slovenian dog and cat owners, regardless of their experience with cannabis products. The questionnaire consisted of six sections related to demographic data and personal experience with CBD use, information about the participant's animal, experience with CBD use in the participant's animal, reasons for not using CBDs in their animal, attitudes toward CBD use in dogs and cats, and postmodern health values. Descriptive statistics were performed to analyze demographics, personal experience with CBD use, and experience with CBD use in dogs and cats. Hierarchical multiple regression using the enter method was performed to analyze the important predictors of CBD use. A total of 408 completed questionnaires were included in the statistical analysis. A substantial proportion (38.5%) of owners had already used CBDs to treat their animal. Positive attitudes and previous personal experience were significant (p < 0.05) predictors of first use and reuse of CBDs in pets, while postmodern health values were not. In conclusion, the decision to use CBDs for medicinal purposes is based on acquired information and personal experience. Veterinarians should be informed and familiar with CBDs as a treatment option. However, further research is essential to establish the use of CBDs in veterinary medicine. Improved laws and regulations are also needed to ensure that only high-quality medications are prescribed to dogs and cats.
Appunti di tattica (De militari scientia). Testo critico, traduzione e commento
Authors: Eramo Immacolata
Published: January 2022

Au premier tiers du VIIe siècle, sous le règne d’Héraclius, un officier anonyme de l'armée de l'Empire romain d'Orient rédige des notes pour son contingent de cavalerie, s'inspirant du Strategicon de Maurice, et utilisant sans doute un manuel d’instruction. Le résultat est ce petit traité, dernier produit de la première phase de la polémograhie byzantine : une source fondamentale de la pratique militaire au septième siècle. Cet ouvrage est unique dans son genre, car il ne s’agit pas d’un manuel systématique, mais d’une véritable collection de notes de tactique. Le texte est proposé dans une nouvelle édition critique, traduite et commentée pour la première fois.
KEY ASPECTS OF THE DEVELOPMENT OF CONDUCTING PERFORMANCE IN CHINA
Authors: Yan Yang
Published: January 2022

Statement of the problem. Conducting performance in China is still a poorly explored area of the national musical art, which makes it necessary to deeply comprehend its main aspects and determine the originality of this important area of the country’s musical culture. This study is aimed at identifying the influence of the dynamics of historical development in China in the 20th century on the development of a conductor’s profession in the country. The recent researches and publications study the specifics of the conductor’s gesture (M. Mannone, I. Poggi, B. Silvey, L. Reizabal), personal conducting activities of the brightest representatives of this profession in different countries (C. Bongiovanni, J.-C. Branger, J. Orrego Salas, M. Walter and others). However no work mentions the activities of Chinese conductors. This profession is practically not studied among its Chinese representatives, too. Methodology of this research includes the study of scientific works devoted to various aspects of European conducting (R. Komurdzhi, Lee En Zhong, B. Smirnov, O. Tremzina), to the outstanding conductors (S. Bongiovanni, J.-C. Branger, J. Orrego Salas, M. Walter), general problems of connection of conducting with exact sciences (M. Mannone), and, especially, the history of the development of a new type of symphony orchestra in China (Hon-Lun Yang & M. Saffle, Mingyen Lee). Hence, it calls for an integrated approach, which includes historical-typological, comparative, genrestyle and dialectic methods. Results and Conclusions. Active involvement of European music has been taking place in China relatively recently – since the 1920s. In this way, the problems of creating a national conducting school and a symphonic culture of performance in the country became especially acute. The history of the development of the symphony orchestra and conductor’s performance of Chinese musical art of the twentieth century can be imagined as a single culture process that is constantly moving in the same vein encompassing all countries and continents. During the 20th century a new profession of musician-conductor of a new type of orchestra was formed in China, which combined instruments of the European symphony orchestra and national instruments. The formation of national symphonic schools in China is also linked to specific historical events: the modernization of Chinese music, the foreign education of many Chinese musicians, the influence of communist ideology (“exemplary performances”), on the one hand, and Western capitalist (Hong Kong orchestras), on the other. The specificity of the activity of the conductor of a new type of symphony orchestra is directly related to various changes in the quantitative and qualitative composition of the orchestra, special features for use of both individual instruments of the symphony orchestra and whole sections, and to technical capabilities of national and European instruments.
The Role of the Mask in Preventing and Controlling the Coronavirus Disease 2019 Pandemic
Authors: Tajvar Abdolhamid , Mouseli Ali , Ghaffari Hamid Reza
Published: January 2022

Following the outbreak of novel coronavirus disease 2019 (COVID-19), there have been debates among scientific communities, officials, and the public about the role of the mask in controlling and preventing this disease. Nonetheless, there are some ambiguities regarding various aspects of the mask which are still important to be addressed, including the type of the mask to be used, the situation in which the mask should be used, the correct way to use the mask, and the effectiveness of the mask in preventing the disease. Accordingly, addressing these ambiguities could change policy trends and public beliefs about the use of mask and help control the disease. To this end, this study discusses the role of the mask in preventing and controlling the COVID-19 pandemic.
Bioinformatic Evaluation of the miRNAs Targeting ACE2 Gene in COVID-19
Authors: Rafat Milad , Roshan Aida , Abyar Mahya , Keramati Saba , Nikpoor Amin Reza
Published: January 2022

Introduction: Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which began in late 2019 in Wuhan, China, has become a global epidemic. Angiotensin 2 converting enzyme (ACE2) acts as a receptor for host function to cause acute coronavirus 2 acute respiratory syndrome (SARS-CoV-2). ACE2 is abundantly expressed in different cells of different human organs. In human physiology, ACE2 is a major player in the renin-angiotensin-aldosterone (RAAS) system by degrading angiotensin II. Many factors have been associated with altered ACE2 expression and the severity and progression of COVID-19, including microRNAs that may be effective in it. Identifying pathological changes due to SARS-CoV-2 infection is important because it has major implications for understanding the pathophysiology of COVID-19 and developing evidence-based treatment strategies. Currently, many intervention strategies are being explored in ongoing clinical trials. Objective: The aim of this study is to use bioinformatics databases to find potential antiviral therapies against SARS-CoV-2 through host microRNAs (miRNAs) that can reduce viral gene expression to inhibit virus entry and replication. Methods: Using different algorithms in TargetScan, DIANA, ENCORI and miRWalk databases, the potential microRNAs were identified that target ACE2. Then, a score table was prepared from the candidate microRNAs, based on the affinity of the seed region of microRNAs and the 3`-UTR region of the ACE2 gene. Finally, microRNAs with higher scores were chosen as candidates for practical analysis. Results: The results of Bioinformatical analysis showed that Has-miR-200c-3p, Has-miR-29a, Has-miR-29c, and Has-miR-942 are most likely to inhibit ACE2. These microRNAs are the most potent factors that might be affected on ACE2 during virulence. Conclusion: It seems that ACE2 is under the control of the miR-200c-3p and plays a crucial role in the pathophysiology process. Therefore, this microRNA can be considered as a suitable new candidate for experimental evaluation.
A Review of the Prevalence and Diagnostic Points of Cryptosporidium Species in Immunocompromised and Healthy Human Samples in Iran
Authors: Etemadi Soudabeh , Raiesi Omid , Getso Muhammad I. , Raissi Vahid , Hoseini Hosnie
Published: January 2022

Cryptosporidium species are important intestinal pathogens with widespread distribution in humans and other hosts. Whereas the parasite causes acute and self-limiting gastroenteritis in people with healthy immune systems, many reports on this infection around the world are limited to people with defective or suppressed immune systems who suffer from a persistent and deadly infection. Using laboratory-serological and molecular methods for the detection of Cryptosporidium species in immunocompromised and healthy human samples, recent studies in Iran indicated that the prevalence of Cryptosporidium species in different samples varied between 0 to 14%. The samples in Iranian studies included human fecal and diarrheic samples from diarrheic children, patients with gastroenteritis, immunocompromised individuals, and people in contact with livestock. Furthermore, some species were reported based on molecular studies including Cryptosporidium parvum and Cryptosporidium hominis. Some studies have also reported Cryptosporidium meleagridis. In this review study, data were collected regarding the prevalence of cryptosporidiosis in high-risk individuals such as children and immunocompromised individuals. The results revealed that the higher prevalence of C. parvum in Iranian studies in the last 10 years may be attributed to the transmission of infection from animal sources.
ANALISIS SUMBER DAYA INTERNAL GUNA MEMBANGUN STRATEGI PEMASARAN UNTUK MENINGKATKAN MINAT BELI
Authors: Adinda Rizka , Barkah Cecep Safa'atul , Herawaty Tetty , Auliana Lina
Published: January 2022

ABSTRAKTujuan penelitian ini adalah untuk menganalisis faktor yang mempengaruhi minat beli konsumen Brekele Chips dan mengusulkan strategi pemasaran yang tepat untuk dapat Brekele Chips terapkan guna meningkatkan minat beli konsumennya. Penelitian ini menggunakan metode kuantitatif dan kualitatif deskriptif. Sampel pada penelitian ini berjumlah 123 penduduk Jawa Barat pada kelompok usia remaja yang diperoleh melalui teknik purposive sampling. Jenis data yang digunakan yaitu data primer yang diperoleh dari wawancara mendalam dengan Brekele Chips dan penyebaran kuesioner ke sampel penelitian. Metode analisis data menggunakan analisis internal based resources, analisis valuable, rare, costly to imitate, dan non-substitutable, analisis sustainable competitive advantage, dan analisis strengths, weakness, opportunities, dan threats. Berdasarkan analisis sumber daya internal yang dimiliki, hasil menunjukkan bahwa Brekele Chips dapat menerapkan suatu strategi pemasaran untuk meningkatkan minat beli konsumennya melalui pengadaan event marketing creative challenge. ABSTRACTThe purpose of this study is to analyze the factors that influence the buying interest of Brekele Chips consumers and propose the right marketing strategy to be able to apply Brekele Chips to increase consumer buying interest. This research uses descriptive quantitative and qualitative methods. The sample in this study amounted to 123 residents of West Java in the adolescent age group obtained through purposive sampling technique. The type of data used is primary data obtained from in-depth interviews with Brekele Chips and distributing questionnaires to the research sample. The data analysis method uses internal based resources analysis, valuable, rare, costly to imitate, and non-substitutable analysis, analysis of sustainable competitive advantage, and analysis of strengths, weaknesses, opportunities, and threats. Based on the analysis of its internal resources, the results show that Brekele Chips can implement a marketing strategy to increase consumer buying interest through the provision of creative challenge marketing events.