bluuebunny/crossref_metadata_2025 huggingface dataset:
COMPUTED-ASSISTED DIAGNOSIS IN DIAGNOSTIC CERVICAL CANCER IMAGING : A TEN YEARS SYSTEMATIC REVIEW
Authors: Kusuma Dewi Rahmita , Kurnia Dewi Asri , Meitadani Nandya
Published: February 2024

Background: Cervical cancer is one of the most common malignant tumors in the world, and it is the fourth leading cause of cancer in women. The morbidity and mortality of cervical cancer in the developing countries are distinctly higher than those in the developed countries. Computer-assisted diagnosis is key for scaling up cervical cancer screening, but current algorithms perform poorly on whole slide image analysis and generalization. 
The aim: This study aims to show about computed-assisted diagnosis in diagnostic cervical cancer imaging.
Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2014 and 2024 were taken into account. Several different online reference sources, like Pubmed and SagePub, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.
Result: In the PubMed database, the results of our search brought up 153 articles, whereas the results of our search on SagePub brought up 180 articles. The results of the search conducted for the last year of 2014 yielded a total 53 articles for PubMed and 72 articles for SagePub. The result from title screening, a total 18 articles for PubMed and 27 articles for SagePub. In the end, we compiled a total of 10 papers. We included five research that met the criteria.
Conclusion: Computed-assisted medical diagnosis can successfully complete a variety of medical tasks by efficiently exploring the essence of a large amount of clinical data. The colposcopy-guided cervical biopsy is essential for detecting CIN in cervical cancer screening, but there are difficulties with increasing sensitivity globally.
PROGNOSIS OF MYASTHENIA GRAVIS: A COMPREHENSIVE SYSTEMATIC REVIEW
Authors: Maharani Shabrina , Ramadani Latifah
Published: February 2024

Background: The complex disease progression and treatment challenges affect the overall prognosis in myasthenia gravis (MG) patients. Recent advancements in managing MG have brought about significant progress in attaining complete stable remission  as the treatment objective. This study aims to systematically review the prognosis of MG in literatures of the last 10 years.  
Methods: This systematic review complied with the PRISMA 2020 standards and focused on full-text English literature published between 2014 and 2024. Articles such as editorials and review papers from the same journal, as well as submissions lacking a DOI, were excluded from consideration. Literature was sourced from online platforms like PubMed and SagePub.  
Result: We found 627 articles on PubMed and 810 articles on SagePub. Restricting our search to the past decade (2014-2024), PubMed presented 425 articles, whereas SagePub presented 309 articles. From these, we selected 5 papers meeting our criteria, with 2 from PubMed and 3 from SagePub.
Conclusion: Significant progress has been achieved in treating MG over the past decade. While some patients experience spontaneous remission, the majority require treatment with steroids or similar drugs. Other treatment modalities such as monoclonal antibody treatment, pulmonary function testing, and thymectomy can be employed to improve the prognosis of MG.
Cultura do Medronho
Authors: Fernandes António
Published: February 2024

Esta obra, escrita de uma forma rigorosa mas acessível, aborda a cultura do medronho desde a sua importância histórico-geográfica, passando pela sua caracterização e perfil nutricional, bem como pelos seus diversos aspetos culturais, até às potenciais utilizações do medronho e medronheiro. São expostos temas como a fisiologia e morfologia da planta, as técnicas de cultivo, as formas de propagação, a época de colheita e as condições pós-colheita, os custos de instalação e manutenção, bem como as características químicas da planta e a importância reconhecida dos seus componentes, por exemplo para a produção de mel, aguardente e licores, e ainda apresentadas algumas receitas.
An Examination of Constraints of Taxing the Informal Sector and the Impact on Revenue Mobilisation in Zambia
Authors: Kawimbe Dr. Sidney , Mulonga Pride
Published: February 2024

Taxation is a fundamental tool for revenue generation, economy building and sustainability, reducing market externalities, regulating trade, stimulating representation and achieving tax justice as well as building state accountability and responsiveness. The informal sector in developing countries generally and Zambia particularly has been considered a hindrance to effective domestic revenue mobilisation, hence the rejuvenated focus to bring the sector into the tax baskets. Through a critical literature review, this study sought to identify the varying motivations tabled by the various stakeholders (policy-makers, scholars and tax administrators) in literature on the need to administer tax on this sector and to strengthen enforcement and to evaluate the plausibility of these motives critically. A total of 34 journal articles extracted from Goggle scholar, Research gate, Semantic Scholar and JSTOR formed the literature review. The factors were aggregated into five major groups: political interference, high cost of collection, lack of formality and limited potential for revenue. This study, therefore, conducted a profound evaluative analysis of literature on these factors, pinpointing any voids that future research could address and accordingly sought to contribute to the guidance offered to policy-makers on how to improve informal sector. The study shows that political interference with frequency of 12 at 35%, followed by limited revenue potential with frequency of 9 at 26%, high cost of collection with frequency of 8 at 24% and lack of formality at frequency of 5 at 15% in that order.
INNOVATIVENESS AND PERFORMANCE: A MEDIATING ROLE OF CUSTOMER SATISFACTION IN SMALL AND MEDIUM PRINTING FIRMS IN ABUJA, FEDERAL CAPITAL TERRITORY, NIGERIA
Authors: Felicia EZE, , Adamu Abdul
Published: February 2024

This study examines innovativeness and performance: a mediating role of customer satisfaction in printing firms in Abuja, Federal Capital Territory, Nigeria. The study adopted a survey research design. The population of this study consist of 741 employees of registered printing press with Corporate Affairs Commission (2020), Abuja, FCT. The study used Taro Yamane’s formula to determine the sample size of 260 employees of Printing Press in Abuja, Nigeria. The method of data collection used was a questionnaire that was administered to the respondents. The statistical tool used is Partial Least Square Structural Equation Model (PLS-SEM). The findings revealed a positive effect of innovation on the performance of printing press firms in Abuja. Also, innovation has the strongest effect on customer satisfaction of small and medium printing firms in Abuja; also, innovation has the strongest effect on performance of small and medium printing press firms in Abuja and; customer satisfaction has the strongest effect on performance small and medium printing firms in Abuja. The study concluded that there is a positive effect of innovation on the performance of printing firms in Abuja, Nigeria. Also, innovation has the strongest effect on customer satisfaction of small and medium printing firms in Abuja. Customer satisfaction has significant effect on performance small and medium printing firms in Abuja and innovation has significant effect on performance of small and medium printing firms in Abuja. Based on the conclusion, it was recommended that printing firms should continue using innovation in terms of product innovation, technology innovation, process innovation, marketing and incremental innovation since it significantly contributes to performance in terms of sales increase, growth, market performance and increase in market share; and also ensure customer satisfaction in the organizations.
Engagement of Patient and Her Family Members into Cesarean Section Decision
Authors: Cheishvili Jilda
Published: February 2024

ამ თემაში საუბარია ,რომ საკეისრო კვეთის რიცხვის რაოდენობამ იმატა , განსაკუთრებით ხშირია კვეთა დედის “დაჟინებული ” მოთხოვნით . მოცემული პრობლემის გამოსაკვლევად მიზნად დავისახეთ კვლევის ჩატარება , რომელსაც უნდა ეპასუხა მთავარ კითხვაზე – საკეისრო კვეთის გადაწყვეტილების მიღების მომენტში პაციენტისა და მისი ოჯახის წევრები ფლობდნენ თუ არა სწორ და სათანადო ინფორმაციას . კვლევა ჩატარდა იმერეთის რეგიონში , ქუთაისის დედათა და ბავშვთა სამხარეო დიაგნოსტიკურ ცენტრში . 2010 წლის მონაცემების საფუძველზე საკეისრო კვეთა გაკეთდა 792 შემთხვევაში , რანდომიზაციის წესით ამორჩეულ იქნა რესპოდენტები განხილული იქნა ისტორიების მონაცემები და გაკეთდა მათი ანალიზი , დედებმა უპასუხეს სპეციალურად შემდგარ კითხვარს . კვლევის საფუძველზე შეგვიძლია ვიმსჯელოთ, რომ საკეისრო კვეთით მშობიარობა პირდაპირკორელაციურ კავშირშია ნაყოფის /ახალშობილის და დედის (ადრეული , მოგვიანებითი ) შემდგომ გართულებებთან. კვლევის შედეგად ნათელი გახდა , რომ მთავარ პრობლემასწარმოადგენს დედისთვის ინფორმაციის დეფიციტი და მშობიარობის მართვის არცოდნა . პრობლემის აღმოფხვრისათვისაუცილებელია არამარტო დედის არამედ ზოგადად საზოგადოების ინფორმატიულობა ბუნებრივი მშობიარობის უპირატესობის შესახებ . ამისათვის საჭოროა ყველა საინფორმაციო საშუალების გამოყენება .
The Salesperson’s Social Influence Principles in the Process of Buying
Authors: Tsitskishvili Rusudan
Published: February 2024

სოციალურ ზეგავლენას მნიშვნელოვანი ადგილი უჭირავს სხვადასხვა სფეროში და მათ შორის არის სამომხმარებლო ქცევა. სამომხმარებლო ქცევის ერთ-ერთი შემადგენელია უშუალოდ ყიდვის განხორციელების პროცესი. ამ დროს მომხმარებელზე მრავალი ფაქტორი მოქმედებს. ერთ-ერთი ძირითადი ფაქტორი არის გამყიდველი. გამყიდველი იყენებს სხვადასხვა ფაქტორს მომხმარებელზე ზეგავლენის მოსახდენად. ამისათვის ის უპირველეს ყოვლისა უნდა იყოს აღქმული მომხმარებლის მიერ როგორც მიმზიდველი და სანდო. გარდა ამისა, გამყიდველი ზეგავლენის მოსახდენად იყენებს მთელ რიგ ტექნიკებს. მათ შორის ძირითადია: სხვა მომხმარებელთა ქცევის დამოწმება, პროდუქტის შეზღუდული რაოდენობით წარმოდგენა, თანამიმდევრული დათანხმება, დავალებულობის გრძნო-ბის გამოწვევა, კონტრასტული აღქმა. ამ პრინციპების ცოდნა და მათი კრეატულად გამოყენების უნარი არის აუცი-ლებელი პირობა თანამედროვე კონკურენტულ სამყაროში გადასარჩენად.
Kipchaks in Georgia
Authors: Alasania Giuli
Published: February 2024

საქართველოში ყივჩაყთა გადმოსვლას მეცნიერთა უმრავლესობა 1118 წლით ათარიღებს. ყივჩაყთა ჩამოსახლებასსაქართველოში როგორც დადებით მოვლენას აფასებს დავითის ისტორიკოსი. ძირითადადა სეთივე თვალსაზრისია ქართულ ისტორიოგრაფიაში. ამასთანავე, ყივჩაყების საქართველოში ყოფნასთან დაკავშირებით ლიტერატურაში აზრთა სხვადასხვაობაა. ნაშრომში განხილულია ჩამოსახლებულთა რაოდენობა, მათი განსახლების ადგილი, ინტეგრაციის ხარისხი და ურთიერთობა ადგილობრივ მოსახლეობასთან. ნაშრომში გაზიარებულია აზრი მათი სამხრეთ და სამხრეთ-დასავლეთ საზღვრებზე დასახლების შესახებ; გაზვიადებულად არის მიჩნეული დავითის ისტორიკოსის ნაშრომში მითითებული რიცხვი 40, 000 და მცდარად შეხედულება მოგვიანებით მათი რიცხვის გაზრდის შესახებ. სტატიაში უარყოფილია შეხედულება ყივჩაყთა სწრაფი ასიმილაციის შესახებ ზოგიერთი გამონაკლისის გარდა, გამოთქმულია აზრი მათიძირითადი ნაწილის სამშობლოში დაბრუნების შესახებ დავითის გარდაცვალების შემდეგ. ნაშრომში განხილულია ყივჩაყების სტატუსი საქართველოში თამარისა და მის შემდგომ ხანებში.
The Achaemenids in Georgia According to The Georgian Chronicle
Authors: Sanadze Manana
Published: February 2024

,,ქართველთა ცხოვრების” იმ ინფორმაციების ანალიზს, რომლებიც ქართლში მეფობის დაწყებამდე და ფარნავაზის გამე-ფებამდე ხანაზე მოგვითხრობენ, შემდეგ დასკვნებამდე მივყევართ: ძვ. წ. VII-IV სს-ში, უფრო ზუსტად ალექსანდრემაკედონელის მიერ აქემენიანთა იმპერიის დანგრევამდე, სამხრეთ კავკასიაში ერთმანეთს იქ დამკვიდრებული სკვითურიმომთაბარე ტომები და აქემენიანები ებრძოდნენ. სამხრეთ კავკასიაში და მათ შორის საქართველოს ტერიტორიაზე დამკ-ვიდრებული სკვითები ორ ნაწილად იყოფოდნენ: თავდაპირველად მოსულები და დამკვიდრებულები, რომლებსაც “ქართ-ველთა ცხოვრება” ,,ბუნ-თურქებს” და ,,ხაზარებს” უწოდებს და მოგვიანებით, უკვე მიდიის მეფის ქიაყსარისაგან გამოდევ-ნილები და თავიანთ ძველ თანამეტომეებს შემოერთებული ,თურქები” და ,,ხონები”. სკვითებს ადგილობრივ კავკასიურ,მათ შორის ქართულ მოსახლეობასთან ლოიალური დამოკიდებულება ჰქონდათ, მით უფრო, რომ ერთად ლაშქრობდნენსაერთო მტრის – აქემენიანთა სპარსეთის წინააღმდეგ.
The Second Wave of Revolutions in the 21st Century - the Arab Spring
Authors: Barbakadze Sophio
Published: February 2024

21-ე საუკუნის დასაწყისმა მსოფლიოს თავი რამდენიმე მნიშვნელოვანი მოვლენით დაამახსოვრა, რომელთაშორის ერთ-ერთი უმთავრესი რევოლუციების სრულიად ახალი ფორმის-ხავერდოვანი რევოლუციების გამოჩენაიყო. ხავერდოვანი რევოლუციის ცნების, მისი ხასიათის, წარმოშობის მიზეზებისა და სამომავლო განვითარებისირგვლივ აზრთა სხვადასხვაობა წარმოიშვა. ამასთანავე, 21-ე საუკუნის მეორე ათწლეულმა თან მოიტანა ხავერ-დოვანი რევოლუციის ახალი ფორმა, რომელიც ,,არაბული გაზაფხულის”, ,,არაბული გამოღვიძებისა” და ,,ჟასმინისრევოლუციის” სახელითაა ცნობილი. სტატიის მიზანს წარმოადგენს სწორედ ამ ახალი ფორმის რევოლუციისსიღრმისეული ანალიზი, მისი რევოლუციური პროცესის შესწავლა, არაბული რევოლუციის შედარება ტრადიციულდა ხავერდოვან რევოლუციებთან და მისი მნიშვნელობის დადგენა როგორც უშუალოდ ახლო აღმოსავლეთისთვის,ისე ხავერდოვანი რევოლუციების ,,პირველი ტალღის” ქვეყნებისთვის უპირველეს ყოვლისა-საქართველოსთვის.
The Dates of the Reign of Vakhtang Gorgasali
Authors: Sanadze Manana
Published: February 2024

Georgian historiography dates the reign of King Vakhtang Gorgasali to the 2nd half of V c. The king is considered to have died in 502 in a fight with Persians. Cyril Toumanoff has expressed an opinion about the identi-fication of Vakhtang Gorgasali with the King of Kartli Gurgen, mentioned by Procopius of Caesarea in 523. Accordingly, he believed that in case of such an identification, Vakhtang Gorgasali should have died in 527 dur-ing the big Persian invasion of Georgia. We have noticed that the author of the martyrdom of David and Constantine, who was based on the an-cient chronicle (‘Dzveli Utskebani’ - Old Story) and who created his hagio-graphic work in the middle of XI c., made a big mistake: erroneously, due to the similarity of names, he identified the sons of Georgian King Vakh-tang Gorgasali Darchil and Mihrdat and the invasion of Persians in their reign with the sons of the ruler of Georgia (Kartli) Stephanoz III Mihrdat and Archil and invasions of Arabs and Marwan ibn Muhammad (Murvan Qru - “Marwan the Deaf”) that took place two centuries later, in the 30s of VIII c. Consequently, the author related the martyrdom on the back-ground of Arab invasions. The fact that according to the author of the martyrdom, the sons of Vakhtang Gorgasali were in West Georgia, name-ly Anakopia, and fought the so-called Arabs there, makes it clear that the historical developments were taking place in the period of the Great Per-sian-Byzantine War of 542-562. In the title of the work it is mentioned that the invasion, during which the martyrdom of David and Constantine took place, happened in the vicinity of the death of Vakhtang Gorgasali. Thus, it becomes clear that King Vakhtang Gorgasali could not have died during the Persian-Byzantine War of 502-505 and that the Great Invasion of Persians described in the “Georgian Chronicles”, in which Vakhtang Gorgasali was wounded, could only have happened in 527; the king must have died during a war between Persia and Byzantium in 527–532, more specifically in 527 when Persians invaded Georgia. Proceeding from the above, the surmise of Cyril Toumanoff regarding the death of Vakhtang Gorgasali in 527 becomes more convincing and well-grounded. Since it is known that King Vakhtang Gorgasali lived 60 years, the date of his birth can be presumed to be 466-467. This gives us an opportunity to establish a more precise date of reign of Vakhtang’s father - Mirdat and his grand-father - Archil. The dates of reign we have put forward for kings Mirdat and Archil (Archil - 430-463, Mirdat - 463-473) correspond to the infor-mation of the Assyrian version of the Life of Peter the Iberian.
The Role of Interdisciplinary Approach in ELT
Authors: Kutalia Maka
Published: February 2024

The paper deals with interdisciplinary approach of teaching English ter-minologies. Since language competence is linked with career options, sta-tus, and so forth, the presence of specific terminological barriers among the students from different faculties also has to be acknowledged. This demands interdisciplinary approaches in teaching process. Specific termi-nology is the standard vocabulary used in the professional field. Profes-sionals can conduct communication successfully by using terminologies easily and accurately.The research involved gathering date on learners views on their learn-ing needs and expectations, on encountered difficulties in learning Eng-lish terminologies at university, the degree of importance of proficiency in professional areas of language, and collecting and analysing learners.Empirical research questions relate to:1. The importance of interdisciplinary approach in the process of teach-ing English medical terminology2. How to use an interdisciplinary approach
Is Multi-Level Governance a Political Choice or a Service Delivery Necessity?
Authors: Kakubava Nino
Published: February 2024

The notion of multi-level governance first appeared with the estab-lishment of the European Union to describe the transfer of power upwards and downwards. Later, the power transfer appeared not only vertically, but also horizontally by involving non-gover-nmental, voluntary and private sector into public policy making. Apparently, traditional model of policy making has been chal-lenged and replaced by a more complex, decentralized structure, better able to accommodate citizens’ needs at various levels. How-ever, whether states transfer authority for the purpose of better service delivery or whether they do it under pressure is still un-clear. This paper aims at answering this question by examining various types of multi-level governance and analyzing recent de-velopments in the UK policy as a case.
The Practice of Competition Regulation in the International Procurement and State Procurement Administration in Georgia
Authors: Khomeriki Temuri
Published: February 2024

Under conditions of the emerging economy, together with the mobilization of the state income, it becomes increasingly important to rationalize the expenses. Under the market economy the government has to intervene in the market functioning in order to protect competitive mechanisms that ensure democratic choice. The regulations of the government includes the implementation of state economic policy, as well as addressing the issues that otherwise are impossible to be solved with self-regulating market mechanisms. The function of supervision the competition legislation is shifting to the judiciary and the special regulatory institutions, but the state procurement administration and anti-monopoly regulations still remain the prerogative of the executive body(the government). In the international practice the systems of the international procurement differs from each other, though they have common characteristics mainly regarding the general principles and applied methods. In addition, the level of procurement centralization and the administration quality varies from country to country. Also in each state there is at least one governmental body(in form of an agency, department, office, etc) that regulates and exercises the overall coordination of the procurement policy throughout the country. Generally this very body is responsible for the monitoring state procurement and administrating the signed contracts. In some countries additionally a special governmental office of public provision is made up that carries out the procurementof standard products and services through tenders on the basis of orders placed by state managing bodies and different organizations and then supply appropriate companies. As it turned out, the similar body is to be established in the near future in Georgia.In order to successfully introduce in Georgia the positive experience existing in the international procurement-management practice, it is equally important to have high quality law, also appropriate institutional infrastructure, the support from the authorities. In addition, it is essential to ensure the availability of the information necessary for public monitoring and the professionalism of the parties participating in the procurement process. In Georgia the law regulating the state procurement is mainly harmonized with internationalstandards, though some indirect related legal acts need further refinement. The experience of the international procurement proves that it is equally important to correctly plan the state procurement, as well as correctly organize the procurement procedures and sign fair contracts. In addition, it is important that obligations written in the contracts are fully implemented and public monitoring requires that the accountability system is strictly defined.
Cultural Characteristics and Global Branding
Authors: Bibilashvili Leli
Published: February 2024

Brand strategy is essential for the company; brand determines communicationcontent. The impact of brands is now manifest in every singleaspect of business . Product may be considered as brand only if it entersand covers the global market and is globally aware. For that it isimportant to take into account cultural characteristics. Different culturalrepresentatives react in various manner on one and the samefactor, cultural factor identification is the main keys to success. Articleemphasizes the role of culture in branding illustrating various secondaryand primary research data, covering issues like media characteristics,segmentation, preferences and etc. Brand strategy should be discussedin terms of globalization, it should be flexible and customizedaccording to the relevant environment.
Infusion of Contemporary Issues in the Undergraduate Social Studies Programs of Two National Universities
Authors: Bamidele Adeyemi Michael
Published: February 2024

The purpose of this paper is to gain deeper insights into the way Social Studies programs are structured and taught in two national universities; one from Botswana and the other one from Nigeria; including, the extent of the infusion and presentation of contemporary issues in their Social Studies programs, program similarities, and the challenges faced by lecturers in the teaching of topics related to contemporary issues at the undergraduate level. Using a case study approach, this paper examines how contemporary issues, such as HIV/AIDS, drug abuse, child abuse, social policy, violence, reproductive health, climate change, to mention a few, are infused in the Social Studies programs of the two institutions under study, one each from Nigeria and Botswana. Methods of data collection were both qualitative and quantitative and they included case study of the Social Studies programs at the two universities. It was found that the Social Studies programs were structured along the use of integrated methodology with the infusion of contemporary issues across their courses with a high degree of similar content areas and challenges. The recommendations focused on the availability of teaching materials, enlarged classroom space, regular workshops, the use of external examiners, regular program reviews, among others.
The Participation of the Russian Federation In Nagorno Karabakh Resolution
Authors: Alexeichenko Aleksandre
Published: February 2024

This article explores the causes of the Nagorno-Karabakh conflict while analyzing the possible solutions along with the possible role of the Russian Federation in the settlement of the Nagorno-Karabakh issue. The author believes that the Russian Federation has all the necessary instrumentalities of power – military and political, econo-mic and diplomatic – to resolve the Nagorno-Karabakh conflict, which for a quarter of a century has been a threat to the regional security in the Caucasus and in the entire Middle East.
Emotional Intelligence: Way We Work
Authors: Birwatkar Vaibhav P.
Published: February 2024

The notion of emotional intelligence has become a scientific construct for understanding implications of behavior and adaptation of the individual to his environment. An employee commitment, together with a competent workforce seemed to be of decisive importance for a corporate to be able to compete in quality and to go along with changes. The present article is culmination of the research work, testing the awareness level of the concept of emotional intelligence, the emotional intelligence level of managers across the organizations; whether managers use emotional intelligence competencies to enhance their leadership skills and do managers recognize emotions of different stakeholders in designing their policies. This was done through a quantitative study and these constructs were operationalized by means of a pre-designed questionnaire. The correlation and regression results seem to indicate that there is an awareness of emotional competencies among managers, managers have moderate level of emotional intelligence and they use these competencies to enhance their leadership skills.
Identifying Socio-Economic Characteristics Affecting Poverty in Rural Areas of Armenia
Authors: Bokhyan Vardges
Published: February 2024

This study attempts to determine household socio-economic factors affecting household economic conditions in rural areas of Armenia. To that end, an ordered logistic regression model was estimated using data from the Caucasus Barometer survey conducted by the regional office of the Caucasus Research Resource Centers in Armenia in 2013. The results of the estimation showed that household head health status, monthly household income, education level, and age composition of household were statistically significant determinants of household eco-nomic conditions.
Psychology of Online Customer Behavior
Authors: Meparishvili Ketevani
Published: February 2024

The online environment has been dramatically affected by customer behavior over the past years. The challenge of a sophisticated marketer became to outline the factors, which influence customer behavior in order to better plan future marketing objectives. Various dependent and independent factors exist, which are mainly grouped into social and psychological variables. Customers are constantly changing their preferences and behavior through the internet along with technological advance-ments. It became inevitable for a company to outline what the online user experience generates in the minds potential buyers. How the customer goes through the sales tunnel and what leads toward the decision to buy a certain product/service? The aim of this article is to outline the peculiarities of social and psychological factors over the web, which play a key role in internet customer behavior.
Forecasting of Currency Exchange Rates Variance
Authors: Lemonjava Givi
Published: February 2024

The report reviews currency exchange rate forecast issues. For this reason, corresponding time series have been studied based on which features of this type of series have been determined. Taking into account nature of these features, several models have been processed for currency exchange rate forecasting. Comparing the results of the models, the best model is selected and used for estimate currency exchange rate’s future movements.
The Concept of the “Best Interests” of the Child and its Application in Family Affairs
Authors: Bobokhidze Mariami
Published: February 2024

The article will illustrate an important role of the “best interest” concept of the child regarding realization and protection of children’s rights. It will concentrate on the way of its practical application together with the difficulties arising around the concept, particularly in family related cases, where a child is in a need of special care and treatment. After determining the role of the “best interest” concept regarding realization of children’s rights, its subsequent problems of interpretation and deter-mination, the paper will try to answer the question whether the concept is in fact an effective mechanism in guaran-teeing protection of their rights.
Pertinencia del programa de inglés de la Universidad Americana ante la demanda de profesionales bilingües
Authors: González Llanes Favian Moisés
Published: February 2024

La movilidad social de los estudiantes en la educación superior está relacionada con la competencia comunicativa en otras lenguas de las cuales predomina el idioma inglés. La demanda de profesionales bilingües ha tenido una curva ascendente en los últimos 15 años lo que ha motivado a las instituciones de educación superior a revisar la oferta formativa del idioma inglés. Este ensayo expositivo explora la pertinencia del programa de inglés comunicativo de la Universidad Americana en contraste con la demanda de profesionales bilingüe de Nicaragua. Se describe el contexto macro laboral de la demanda de personal bilingüe del país. Se expone una revisión cronológica de 10 años del comportamiento de la demanda del mercado laboral y se revisa la alineación los estándares del Marco Común Europeo de Referencias con el programa de inglés. Se identifica la pertinencia del programa de inglés y también resaltan aspectos académicos que requieren atención tales como la transversalidad del idioma en las facultades y una mayor oferta de clases de la carrera impartidas en inglés.
El principio procesal de inmediación en las audiencias virtuales en Colombia
Authors: España-Toro Angie Paola
Published: February 2024

Durante los años 2020 - 2021 nuestra sociedad se enfrentó a una emergencia sanitaria surgida por el virus Covid-19, creando un acercamiento jurídico procesal ante la aplicación de diferentes herramientas tecnológicas reguladas por las TIC (Tecnologías de la Información y la Comunicación) dentro de las audiencias públicas en Colombia, de lo cual no se tenía un amplio conocimiento. Es por ello que nace la siguiente pregunta jurídica: ¿cómo se genera la protección del principio procesal de inmediación en las audiencias virtuales en Colombia? Par dar respuesta se tendrá en cuenta tanto la doctrina como la ley colombiana, presentando como puntos de partida el análisis realizado al artículo 107 del Código General del Proceso (ley 1564 del 2012), el cual establece reglas para la aplicación de las audiencias, dando paso a identificar el principio procesal de inmediación dentro de ellas, por medio de diferentes conceptos y mecanismos de protección necesarios con el fin de llegar a la conclusión.
BEHeDaS: A Blockchain Electronic Health Data System for Secure Medical Records Exchange
Authors: Oladele James Kolapo , Ojugo Arnold Adimabua , Odiakaose Christopher Chukwufunaya , Emordi Frances Uchechukwu , Abere Reuben Akporube , Nwozor Blessing , Ejeh Patrick Ogholuwarami , Geteloma Victor Ochuko
Published: February 2024

Blockchain platforms propagate into every facet, including managing medical services with professional and patient-centered applications. With its sensitive nature, record privacy has become imminent with medical services for patient diagnosis and treatments. The nature of medical records has continued to necessitate their availability, reachability, accessibility, security, mobility, and confidentiality. Challenges to these include authorized transfer of patient records on referral, security across platforms, content diversity, platform interoperability, etc. These, are today – demystified with blockchain-based apps, which proffers platform/application services to achieve data features associated with the nature of the records. We use a permissioned-blockchain for healthcare record management. Our choice of permission mode with a hyper-fabric ledger that uses a world-state on a peer-to-peer chain – is that its smart contracts do not require a complex algorithm to yield controlled transparency for users. Its actors include patients, practitioners, and health-related officers as users to create, retrieve, and store patient medical records and aid interoperability. With a population of 500, the system yields a transaction (query and https) response time of 0.56 seconds and 0.42 seconds, respectively. To cater to platform scalability and accessibility, the system yielded 0.78 seconds and 063 seconds, respectively, for 2500 users.
Kronik Gerakan Serikat Buruh di Indonesia: Peta dan Sejarah
Authors: Ahmad Iqbal Faza , Al Ayubbi Syaefuddin Ahrom
Published: February 2024

This research focuses on studying the dynamics of the trade union movement in Indonesia in a historical review and current map of the Trade Union Confederation/Labor Unions registered with the Ministry of Manpower. This study is a qualitative combination of literature and empirical research, combining literature and field data to explore the dynamics of trade unions in Indonesia, especially confederations. Since the 19th century, the birth of the Dutch East Indies Teachers' Workers' Union in 1879 began the emergence of the Workers' Union Movement (SP) or Labor Unions (SB) in Indonesia. These labor organizations, especially in the transportation and plantation sectors, played a central role in Indonesia's struggle for independence. Over time, various labor organizations emerged that played a key role in national political dynamics, such as VSTP, PPKB, and the Indian Vakbonden Association (PVH). Despite experiencing challenges during the Japanese occupation and the failure of the PKI's political action in 1926, the labor movement continued to develop until post-independence, with a major role played by organizations such as SOBSI in the Old Order era, SPSI in the New Order era, and various organizations that emerged during the Reformation era. Since the Reformation era, new trade unions have emerged and old unions have emerged, driven by political reform and the rapid growth of trade and labor unions. The latest mapping shows that more than 4 million workers/laborers are members of more than 20 organizations under various federations and confederations. Organizations such as KSPSI AGN, KSPSI JUMHUR, KSPI, and KSPSI YRS have the most members.
Integration of cloud, fog, and edge technologies for the optimization of high-load systems
Authors: Cherepenin Valentin Anatolyevich , Smyk Nikolai Olegovich , Vorob'ev Sergei Petrovich
Published: February 2024

The study is dedicated to analyzing methods and tools for optimizing the performance of high-load systems using cloud, fog, and edge technologies. The focus is on understanding the concept of high-load systems, identifying the main reasons for increased load on such systems, and studying the dependency of the load on the system's scalability, number of users, and volume of processed data. The introduction of these technologies implies the creation of a multi-level topological structure that facilitates the efficient operation of distributed corporate systems and computing networks. Modern approaches to load management are considered, the main factors affecting performance are investigated, and an optimization model is proposed that ensures a high level of system efficiency and resilience to peak loads while ensuring continuity and quality of service for end-users. The methodology is based on a comprehensive approach, including the analysis of existing problems and the proposal of innovative solutions for optimization, the application of architectural solutions based on IoT, cloud, fog, and edge computing to improve performance and reduce delays in high-load systems. The scientific novelty of this work lies in the development of a unique multi-level topological structure capable of integrating cloud, fog, and edge computing to optimize high-load systems. This structure allows for improved performance, reduced delays, and effective system scaling while addressing the challenges of managing large data volumes and servicing multiple requests simultaneously. The conclusions of the study highlight the significant potential of IoT technology in improving production processes, demonstrating how the integration of modern technological solutions can contribute to increased productivity, product quality, and risk management.
Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing is associated with therapeutic response to splicing inhibitor
Authors: Jablonowski Carolyn , Quarni Waise , Singh Shivendra , Tan Haiyan , Bostanthirige Dhanushka Hewa , Jin Hongjian , Fang Jie , Chang Ti-Cheng , Finkelstein David , Cho Ji-Hoon , Hu Dongli , Pagala Vishwajeeth , Sakurada Sadie Miki , Pruett-Miller Shondra M. , Wang Ruoning , Murphy Andrew , Freeman Kevin , Peng Junmin , Davidoff Andrew M , Wu Gang , Yang Jun
Published: February 2024

Dysregulated pre-mRNA splicing and metabolism are two hallmarks of MYC-driven cancers. Pharmacological inhibition of both processes has been extensively investigated as potential therapeutic avenues in preclinical and clinical studies. However, how pre-mRNA splicing and metabolism are orchestrated in response to oncogenic stress and therapies is poorly understood. Here, we demonstrate that Jumonji Domain Containing 6, Arginine Demethylase and Lysine Hydroxylase, JMJD6, acts as a hub connecting splicing and metabolism in MYC-driven neuroblastoma. JMJD6 cooperates with MYC in cellular transformation by physically interacting with RNA binding proteins involved in pre-mRNA splicing and protein homeostasis. Notably, JMJD6 controls the alternative splicing of two isoforms of glutaminase (GLS), namely kidney-type glutaminase (KGA) and glutaminase C (GAC), which are rate-limiting enzymes of glutaminolysis in the central carbon metabolism in neuroblastoma. Further, we show that JMJD6 is correlated with the anti-cancer activity of indisulam, a “molecular glue” that degrades splicing factor RBM39, which complexes with JMJD6. The indisulam-mediated cancer cell killing is at least partly dependent on the glutamine-related metabolic pathway mediated by JMJD6. Our findings reveal a cancer-promoting metabolic program is associated with alternative pre-mRNA splicing through JMJD6, providing a rationale to target JMJD6 as a therapeutic avenue for treating MYC-driven cancers.
tCFS: A new ‘CFS tracking’ paradigm reveals uniform suppression depth regardless of target complexity or salience
Authors: Alais David , Coorey Jacob , Blake Randolph , Davidson Matthew J.
Published: February 2024

When the eyes view separate and incompatible images, the brain suppresses one image and promotes the other into visual awareness. Periods of interocular suppression can be prolonged during continuous flash suppression (CFS) - when one eye views a static ‘target’ while the other views a complex dynamic stimulus. Measuring the time needed for a suppressed image to break CFS (bCFS) has been widely used to investigate unconscious processing, and the results have generated controversy regarding the scope of visual processing without awareness. Here, we address this controversy with a new ‘CFS tracking’ paradigm (tCFS) in which the suppressed monocular target steadily increases in contrast until breaking into awareness (as in bCFS) after which it decreases until it again disappears (reCFS), with this cycle continuing for many reversals. Unlike bCFS, tCFS provides a measure of suppression depth by quantifying the difference between breakthrough and suppression thresholds. tCFS confirms that: (i) breakthrough thresholds indeed differ across target types (e.g., faces vs gratings, as bCFS has shown) – but (ii) suppression depth does not vary across target types. Once the breakthrough contrast is reached for a given stimulus, all stimuli require a strikingly uniform reduction in contrast to reach the corresponding suppression threshold. This uniform suppression depth points to a single mechanism of CFS suppression, one that likely occurs early in visual processing because suppression depth was not modulated by target salience or complexity. More fundamentally, it shows that variations in bCFS thresholds alone are insufficient for inferring whether the barrier to achieving awareness exerted by interocular suppression is weaker for some categories of visual stimuli compared to others.Research on unconscious vision has proliferated recently, often employing the continuous flash suppression (CFS) method in which rapidly changing shapes viewed by one eye suppress the other eye’s image from awareness. If that suppressed image is progressively strengthened in contrast it will eventually break suppression and emerge into visible awareness. Low breakthrough thresholds are claimed to indicate unconscious processing during suppression. We introduce a method that quantifies breakthrough thresholds and suppression thresholds, thus providing a lower bound missing from previous CFS research. Comparing various image types, including those claimed to undergo unconscious processing, all images show equal suppression when both thresholds are measured. We thus find no evidence of differential unconscious processing and conclude reliance on breakthrough thresholds is misleading without considering suppression thresholds and leads to spurious claims about unconscious processing.
Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant
Authors: Tomlinson Patsy R. , Knox Rachel , Perisic Olga , Su Helen C. , Brierley Gemma V. , Williams Roger L. , Semple Robert K.
Published: February 2024

PIK3R1
encodes three regulatory subunits of class IA phosphoinositide 3-kinase (PI3K), each associating with any of three catalytic subunits, namely p110α, p110β or p110δ. Constitutional
PIK3R1
mutations cause diseases with a genotype-phenotype relationship not yet fully explained: heterozygous loss-of-function mutations cause SHORT syndrome, featuring insulin resistance and short stature attributed to reduced p110α function, while heterozygous activating mutations cause immunodeficiency, attributed to p110δ activation and known as APDS2. Surprisingly, APDS2 patients do not show features of p110α hyperactivation, but do commonly have short stature or SHORT syndrome, suggesting p110α hypofunction. We sought to investigate this. In dermal fibroblasts from an APDS2 patient, we found no increased PI3K signalling, with p110δ expression markedly reduced. In preadipocytes, the APDS2 variant was potently dominant negative, associating with Irs1 and Irs2 but failing to heterodimerise with p110α. This attenuation of p110α signalling by a p110δ-activating PIK3R1 variant potentially explains co-incidence of gain-of-function and loss-of-function
PIK3R1
phenotypes.
Kinases in motion: impact of protein and small molecule interactions on kinase conformations
Authors: Kugler Valentina , Schwaighofer Selina , Feichtner Andreas , Enzler Florian , Fleischmann Jakob , Strich Sophie , Schwarz Sarah , Wilson Rebecca , Tschaikner Philipp , Troppmair Jakob , Sexl Veronika , Meier Pascal , Kaserer Teresa , Stefan Eduard
Published: February 2024

Protein kinases act as central molecular switches in the control of cellular functions. Alterations in the regulation and function of protein kinases may provoke diseases including cancer. In this study we investigate the conformational states of such disease-associated kinases using the high sensitivity of the Kinase Conformation (KinCon)-reporter system. We first tracked BRAF-kinase activity conformation changes upon melanoma drug binding. Second, we also use the KinCon reporter technology to examine the impact of regulatory protein interactions on LKB1-kinase tumor suppressor functions. Third, we explore the conformational dynamics of RIP-kinases in response to TNF-pathway activation and small molecule interactions. Finally, we show that CDK4/6 interactions with regulatory proteins alter conformations which remain unaffected in the presence of clinically applied inhibitors. Apart from its predictive value, the KinCon technology helps identify cellular factors that impact drug efficacies. The understanding of the dynamics of full-length protein kinases when interacting with small molecule inhibitors or regulatory proteins is crucial for designing more effective therapeutic strategies.
A machine learning-based hybrid recommender framework for smart medical systems
Authors: Wei Jianhua , Yan Honglin , Shao Xiaoli , Zhao Lili , Han Lin , Yan Peng , Wang Shengyu
Published: February 2024

This article presents a hybrid recommender framework for smart medical systems by introducing two methods to improve service level evaluations and doctor recommendations for patients. The first method uses big data techniques and deep learning algorithms to develop a registration review system in medical institutions. This system outperforms conventional evaluation methods, thus achieving higher accuracy. The second method implements the term frequency and inverse document frequency (TF-IDF) algorithm to construct a model based on the patient’s symptom vector space, incorporating score weighting, modified cosine similarity, and K-means clustering. Then, the alternating least squares (ALS) matrix decomposition and user collaborative filtering algorithm are applied to calculate patients’ predicted scores for doctors and recommend top-performing doctors. Experimental results show significant improvements in metrics called precision and recall rates compared to conventional methods, making the proposed approach a practical solution for department triage and doctor recommendation in medical appointment platforms.
Evasão no ensino superior brasileiro: uma percepção das predisposições, causas e consequências
Authors: Dos Santos Cidmar Ortiz , Borges Reginaldo , Pereira Junior Edson Hermenegildo , Kunh Peterson Diego , Dos Santos José Airton Azevedo
Published: February 2024

Este trabalho tem por objetivo discutir a evasão no ensino superior sob a percepção das predisposições, causas e consequências.  Assim alinha-se a uma revisão bibliográfica de natureza exploratória. Observa-se que a evasão no ensino superior ainda padece de maior precisão no seu cálculo e conceito. São multivariáveis as causas da evasão, destaque prevalecido para os fatores financeiros, acadêmicos e aspectos psicológicos e individuais. Neste contexto a mitigação dos índices de evasão estudantil é fator incansável das agendas institucionais e governamentais e produz políticas públicas com resultados ainda aquém dos perspectivados. Diante disto observa-se na construção do estudo que a diminuição efetiva dos índices de evasão acontecerá apenas com a melhora nas condições de permanência dos estudantes através de políticas que alinhem fatores construtivos nesta permanência no universo do ensino superior.