bluuebunny/crossref_metadata_2025 huggingface dataset:
Policy, learning and regime change: Western concepts and CEE experience
Authors: Colebatch H.K.
Published: January 2018

This article offers an outsider’s perspective on the place of policy in the analysis of governing in Central and Eastern Europe, both before the change from a communist to a post-communist order, and since. It explores the way in which ‘policy’ is used as a construct in both the practice of governing and the analysis of that practice. It argues that we have to recognise multiple strands – authority, structured interaction, and collective problematisation - in the construction of ‘policy’. It points to a distinction between ‘formal’ and ‘practical’ perspectives, and argues that this distinction reflects structural tensions in the process of ’putting together’ the shared understandings and relationships which make g for ‘governing’, It argues for the importance of continuing research, empirically based and theoretically informed, into the way that governing is ‘put together’ in Central and Eastern Europe, and how both participants and the governed ‘make sense’ of this process.
Transverse Hilbert schemes and completely integrable systems
Authors: Donin Niccolò Lora Lamia
Published: January 2018

In this paper we consider a special class of completely integrable systems that arise as transverse Hilbert schemes of d points of a complex symplectic surface S projecting onto ℂ via a surjective map p which is a submersion outside a discrete subset of S. We explicitly endow the transverse Hilbert scheme Sp
[d] with a symplectic form and an endomorphism A of its tangent space with 2-dimensional eigenspaces and such that its characteristic polynomial is the square of its minimum polynomial and show it has the maximal number of commuting Hamiltonians.We then provide the inverse construction, starting from a 2ddimensional holomorphic integrable system W which has an endomorphism A: TW → TW satisfying the above properties and recover our initial surface S with W ≌ Sp
[d].
A Start-Up’s R&D Stages and the Evolution of Financing Sources: Evidence from the Biotechnology Industry
Authors: Kang Hyunsung D
Published: January 2018

The co-existence of angel, independent venture capital (IVC), and corporate venture capital (CVC) in the entrepreneurial finance market raises a natural question of why a start-up finances its projects from one source over another. This question becomes more complicated to address because a start-up grows or declines dynamically. Using a life cycle theory of entrepreneurial finance, which suggests that a start-up uses several financing sources as it reaches certain thresholds in its life cycle accordingly, I explore this selection issue with my dataset on 113 biopharmaceutical start-ups. I find that these start-ups tend to finance their projects mostly from solely IVCs or CVCs rather than angels and syndicated investors combining IVCs and CVCs when they have more preclinical and phase I products in their R&D pipelines; and from CVCs or syndicated investors rather than angels and IVCs when they do more phase II and phase III products.
In vitro reconstitution and biochemical characterization of human phospholipid scramblase 3: phospholipid specificity and metal ion binding studies
Authors: Palanirajan Santosh Kumar , Sivagnanam Ulaganathan , Murugan Sowmiya , Gummadi Sathyanarayana N.
Published: January 2018

Human phospholipid scramblase 3 (hPLSCR3) is a single pass transmembrane protein that plays a vital role in fat metabolism, mitochondrial function, structure, maintenance and apoptosis. The mechanism of action of scramblases remains still unknown, and the role of scramblases in phospholipid translocation is heavily debated. hPLSCR3 is the only member of scramblase family localized to mitochondria and is involved in cardiolipin translocation at the mitochondrial membrane. Direct biochemical evidence of phospholipid translocation by hPLSCR3 is yet to be reported. Functional assay in synthetic proteoliposomes upon Ca2+and Mg2+revealed that, apart from cardiolipin, recombinant hPLSCR3 translocates aminophospholipids such as NBD-PE and NBD-PS but not neutral phospholipids. Point mutation in hPLSCR3 (F258V) resulted in decreased Ca2+binding affinity. Functional assay with F258V-hPLSCR3 led to ~50% loss in scramblase activity in the presence of Ca2+and Mg2+. Metal ion-induced conformational changes were monitored by intrinsic tryptophan fluorescence, circular dichroism, surface hydrophobicity changes and aggregation studies. Our results revealed that Ca2+and Mg2+bind to hPLSCR3 and trigger conformational changes mediated by aggregation. In summary, we suggest that the metal ion-induced conformational change and the aggregation of the protein are essential for the phospholipid translocation by hPLSCR3.
Conceptual Blending, the Second Naïveté, and the Emergence of New Meanings
Authors: Roberts Jason P.
Published: January 2018

The field of cognitive linguistics has generated a powerful set of theoretical tools for analyzing the ways in which we understand, communicate, and create concepts. In the conceptual integration theory of Gilles Fauconnier and Mark Turner, the cognitive process known as double-scope blending provides a highdefinition model for the phenomenological hermeneutics of Paul Ricoeur. In particular, Ricoeur’s notion of developing a second naivete through the blending of ancient and contemporary worlds of meanings can be viewed as the double-scope integration of concepts across disparate conceptual frames. This re-modeling of Ricoeur’s hermeneutics gives it a new level of clarity and precision in cognitive scientific terms, which in turn may be utilized in service of theological and other forms of discourse. Conceptual integration theory also sheds light on other Ricoeur-inspired hermeneutical models and makes a case for the revelatory character of scripture through the meaning-making process of interpretation. The interpretation of the image of God concept in an evolutionary worldview serves as a heuristic example of second naivete as double-scope blending.
Konstruktionspatterns in der Idiomatik und ihre kognitiven Grundlagen
Authors: Dobrovol’skij Dmitrij , Piirainen Elisabeth
Published: January 2018

The starting point of this paper is a particular idiom category. It deals with idioms that contain determinative compounds of a special kind. The first element of the compound points to the figurative meaning of the idiom, while the second element is a part of the source concept of the metaphor and thus interacts with the literal meaning. An appropriate apparatus for describing idioms of this category is provided by the Conceptual Blending Theory. It is shown that, apart from metaphorization processes, the blending of mental spaces plays a significant part in bringing about the figurative meaning of the idioms. At the same time, the paper supports the recently discussed hypothesis that phrasemes can be constructed according to certain patterns as recurrent form-meaning pairs. Therefore, the paper contributes to Construction Grammar as well as to Blending Theory and clarifies some aspects of idiom semantics and motivation.
Differential Rates of Perinatal Maturation of Human Primary and Nonprimary Auditory Cortex
Authors: Monson Brian B. , Eaton-Rosen Zach , Kapur Kush , Liebenthal Einat , Brownell Abraham , Smyser Christopher D. , Rogers Cynthia E. , Inder Terrie E. , Warfield Simon K. , Neil Jeffrey J.
Published: January 2018

Primary and nonprimary cerebral cortex mature along different timescales; however, the differences between the rates of maturation of primary and nonprimary cortex are unclear. Cortical maturation can be measured through changes in tissue microstructure detectable by diffusion magnetic resonance imaging (MRI). In this study, diffusion tensor imaging (DTI) was used to characterize the maturation of Heschl’s gyrus (HG), which contains both primary auditory cortex (pAC) and nonprimary auditory cortex (nAC), in 90 preterm infants between 26 and 42 weeks postmenstrual age (PMA). The preterm infants were in different acoustical environments during their hospitalization: 46 in open ward beds and 44 in single rooms. A control group consisted of 15 term-born infants. Diffusion parameters revealed that (1) changes in cortical microstructure that accompany cortical maturation had largely already occurred in pAC by 28 weeks PMA, and (2) rapid changes were taking place in nAC between 26 and 42 weeks PMA. At term equivalent PMA, diffusion parameters for auditory cortex were different between preterm infants and term control infants, reflecting either delayed maturation or injury. No effect of room type was observed. For the preterm group, disturbed maturation of nonprimary (but not primary) auditory cortex was associated with poorer language performance at age two years.
Current Knowledge on Intestinal Microbes and Immunity
Authors: Synod Williams J. , Lee Cruz
Published: January 2018

The aggregation of many microorganisms, ranging from virus, bacteria, parasites, to lower plants such as fungi are frequently referred to as the microbiota, colonizes the skin and mucosal surfaces of vertebrates. In man, more than 100 trillion microorganisms, mostly bacteria, colonize the oral-gastrointestinal tract, and the majority of these microbes dwell in the distal digestive tract. A large number of years of co-evolution between the host and microorganisms have prompted a mutualistic relationship in which the micro-biota adds to many host physiological processes and, thus, the host gives niches and supplements to microbial survival. The principal roles of the microbiota to the host incorporate the digestion and fermentation of sugars, the synthesis of vitamins, the improvement of gut-related lymphoid tissues (GALTs), the polarization of gut-specific insusceptible reactions and the aversion of colonization by pathogens. Thus, gut resistant reactions that are initiated by commensal populaces control the creation of the microbiota. Therefore, an overwhelming interchange between the host immune system and the microbiota is fundamental for gut homeostasis. Nevertheless, when the mutualistic relationship between the host and microbiota is disturbed, the gut microbiota can initiate or add to infection. In this review, we will be discussing on both the beneficial and detrimental roles of the gut microbiota.
Challenges in Patients with Diabetes: Improving Clinical Outcomes After Percutaneous Coronary Intervention Through EVOlving Stent Technology
Authors: Byrne Robert A ,   German Heart Centre Munich, Technical University of Munich, Munich, Germany, Banai Shmuel ,   Tel Aviv Medical Center, Israel, Colleran Roisin ,   German Heart Centre Munich, Technical University of Munich, Munich, Germany, Colombo Antonio ,   San Raffaele Hospital, Milan, Italy
Published: January 2018

Patients with diabetes have poorer outcomes after percutaneous coronary intervention than patients without diabetes. The Cre8™ EVO drug-eluting stent (DES) has design features that aim to improve clinical outcomes in patients with diabetes. These include Abluminal Reservoir Technology – a proprietary polymer-free drug-release system consisting of reservoirs on the abluminal surface of the stent that control drug release and direct the drug exclusively towards the vessel wall – and the Amphilimus™ drug formulation, which enables enhanced drug—tissue permeation utilising fatty acid transport pathways. The latter is particularly advantageous in patients with diabetes, whose cell metabolism favours increased cellular uptake of fatty acid. Furthermore, evidence suggests that mTOR inhibitors (-limus drugs) utilised in conventional DES are less effective in diabetic cells. The new stent architecture provides high device deliverability and conformability, facilitating clinical use in complex disease patterns and high-risk lesion morphologies. Clinical evidence for the efficacy and safety of the Cre8™ DES in patients with diabetes has been demonstrated in a number of clinical trials and observational registries. These data are reviewed herein, along with an overview of on-going randomised trials.
Bioprosthetic Valve Fracture During Valve-in-valve TAVR: Bench to Bedside
Authors: Saxon John T ,   Saint Luke’s Mid America Heart Institute, Kansas City, MO, USA;,   University of Missouri – Kansas City, Kansas City, MO, USA, Allen Keith B ,   Saint Luke’s Mid America Heart Institute, Kansas City, MO, USA;,   University of Missouri – Kansas City, Kansas City, MO, USA, Cohen David J ,   Saint Luke’s Mid America Heart Institute, Kansas City, MO, USA;,   University of Missouri – Kansas City, Kansas City, MO, USA, Chhatriwalla Adnan K ,   Saint Luke’s Mid America Heart Institute, Kansas City, MO, USA;,   University of Missouri – Kansas City, Kansas City, MO, USA
Published: January 2018

Valve-in-valve (VIV) transcatheter aortic valve replacement (TAVR) has been established as a safe and effective means of treating failed surgical bioprosthetic valves (BPVs) in patients at high risk for complications related to reoperation. Patients who undergo VIV TAVR are at risk of patient—prosthesis mismatch, as the transcatheter heart valve (THV) is implanted within the ring of the existing BPV, limiting full expansion and reducing the maximum achievable effective orifice area of the THV. Importantly, patient—prosthesis mismatch and high residual transvalvular gradients are associated with reduced survival following VIV TAVR. Bioprosthetic valve fracture (BVF) is as a novel technique to address this problem. During BPV, a non-compliant valvuloplasty balloon is positioned within the BPV frame, and a high-pressure balloon inflation is performed to fracture the surgical sewing ring of the BPV. This allows for further expansion of the BPV as well as the implanted THV, thus increasing the maximum effective orifice area that can be achieved after VIV TAVR. This review focuses on the current evidence base for BVF to facilitate VIV TAVR, including initial bench testing, procedural technique, clinical experience and future directions.
Teorias econômicas marxistas e a Grande Recessão
Authors: PALLUDETO ALEX WILHANS ANTONIO , ANDRADE ROGERIO P. DE
Published: January 2018

RESUMO O presente artigo dedica-se ao exame de algumas das principais interpretações de inspiração marxista acerca da Grande Recessão que se apresentam publicadas sob a forma de livros. Do amplo conjunto de publicações sobre o tema, as seguintes obras foram analisadas: The Great Financial Crisis, de John Bellamy Foster e Fred Magdoff (2009); The Enigma of Capital, de David Harvey (2011), publicada originalmente em 2010; The Crisis of Neoliberalism, de Gérard Duménil e Dominique Lévy (2011); e The Failure of Capitalist Production, de Andrew Kliman (2012). Argumenta-se que o debate marxista em torno das causas últimas da Grande Recessão pode ser sistematizado a partir da seguinte clivagem: 1) de um lado, os autores que atribuem a turbulência à forma política/econômica/institucional específica assumida pelo sistema capitalista ao longo das últimas décadas; 2) de outro, aqueles que interpretam a crise recente como uma manifestação própria da dinâmica capitalista em geral - e não do modo particular que esta supostamente apresenta. Enquanto Foster e Magdoff (2009), Harvey (2011) e Duménil e Lévy (2011) compõem o primeiro grupo, Kliman (2012) pode ser visto como representante da segunda vertente.
The two forms of capitalism: developmentalism and economic liberalism
Authors: BRESSER-PEREIRA LUIZ CARLOS
Published: January 2018

ABSTRACT This paper argues that the state and the market are the main institutions regulating capitalism, and, correspondingly, that the form of the economic and political coordination of capitalism will be either developmental or liberal. It defines the developmental state, relates it to the formation of a developmental class coalition, and notes that capitalism was born developmental in its mercantilist phase, turned liberal in the nineteenth century, and, after 1929, became once again developmental, but, now, democratic and progressive. All industrial and capitalist revolutions took place within the framework of developmentalism, whereby the state coordinates the non-competitive sector of the economy and the five macroeconomic prices (which the market is unable to make “right”), while the market coordinates the competitive sector. In the 1970s, a crisis opened the way for a short-lived and reactionary form of capitalism, neoliberalism or rentier-financier capitalism. Since the 2008 Global Financial Crisis, the neoliberal hegemony has come to an end, and we are now experiencing a period of transition.
The impacts of the early 20 th century physics and mathematics crisis on contemporary economics discourse
Authors: LUPERI MAURICIO MARTINELLI SILVA
Published: January 2018

ABSTRACT Through discussion of several authors, dealing with the process of mathematicization of the economy, we seek to clarify the progress of this process in the world. Mirowski (1991) analyzes this phenomenon and finds that it began more strongly from 1925. However, he does not show in his article as mathematics and physics qualitatively influenced the economy. This is our primary goal in this paper: an account, in a systematic way, of how mathematics and physics have influenced constitution of economics, culminating in the adoption of general equilibrium as metatheory and the generalization of the hypothetical-method deductive.
Underdevelopment in contemporary world:is structuralism still relevant?
Authors: VILAÇA JUNIOR ADEMIR PEDRO
Published: January 2018

ABSTRACT This paper intends to evaluate if the Latin American structuralist approach is still relevant to understand capital accumulation dynamics of peripheral countries and their insertion in the global value chains. It’s a theoretical paper that strives to improve the building blocks of structuralism with the incorporation of elements from different approaches to establish a nexus to understand capital accumulation dynamics in the periphery. Considering the relevance of technological accumulation, its impacts over the productive structure and over the international insertion, we strive to analyze factors that perpetuate income diversion in relation to the center. Under this perspective, we conclude that the particularities of peripheral economies changed their form of manifestation without effectively overcome the dependence relation.
The dynamic intensity of CO 2 emissions: empirical evidence for the 20 th century
Authors: CARNEIRO DIEGO , IRFFI GUILHERME
Published: January 2018

ABSTRACT The debate around the economic growth and environmental degradation is the hot topic among academics. However, up to a point, all of them embrace the uncontroversial view that tells us that anthropic factors have leverage on global climate. It happens that the so-called greenhouse effect is closely related to the accumulation of certain gases in the atmosphere, e.g., carbon dioxide, whose original source comes from productive sectors. Thus, our purpose in this article is to estimate the rate of emission intensity - here we mean the ratio between CO2 emissions and GDP - which has increased since the early part of the 20th century. To support that idea, this study reports on data from 24 different countries. In terms of C02 emission, the results undoubtedly show that United Kingdom and the United States highlight a negative picture, particularly when both are compared to India. It should be noted the presence of structural changes, which coincide with three major historical events: the World War I (1914-1918), the Great Depression in the 1930s, and finally the Oil-price shocks in the 1970s. As the result of the analysis demonstrates, the amount of emission produced by developing countries is surprisingly low. That the technology reveals its relative merit for reducing the overall emission intensity is transparently obvious.
The impact of the Chinese exchange policy on foreign trade with the European Union
Authors: CARDOSO ANA , DUARTE ANTÓNIO PORTUGAL
Published: January 2018

ABSTRACT The aim of this paper is to analyze the impact of the Chinese foreign exchange policy on foreign trade with the European Union. After describing the importance of the exchange rate in an open economy and some of the methodologies employed to calculate its equilibrium value, we examine whether the Chinese competitiveness is due to the existence of misalignment (undervaluation) of its exchange rate, or rather, to other sources of competitiveness. For this purpose, we use a Vector Error Correction (VEC) model to estimate a long-run exports equation. The empirical results indicate that over the past few years, Chinese exports have benefited from an “unfair” competitive advantage resulting from the manipulation of its currency value.
Multiculturalismo e Direito no país das minorias invisíveis: fundamentos e proposições para uma nova leitura da identidade constitucional brasileira
Authors: Dutra Deo Campos
Published: January 2018

O presente trabalho apresenta como hipótese principal a necessidade de que o texto constitucional brasileiro seja interpretado adotando como um dos alicerces de sua identidade constitucional o respeito a identidade cultural, uma das formas da efetivação dos direitos fundamentais do indivíduo. Para isso, esta pesquisa se apoia nos fundamentos de autonomia individual e igualdade desenvolvidos pelo denominado o multiculturalismo liberal para, em um estudo analítico/prescritivo envolvendo teoria política e direito, desenvolver dois objetivos principais. Em seu primeiro momento, pretende-se realizar a análise do papel e dos desafios da constituição dentro das sociedades contemporâneas marcadas pela diversidade cultural. Num segundo momento, procurarmos reconhecer dentro da identidade constitucional brasileira, o lugar e a importância do exercício livre e autônomo da cultura particular de cada indivíduo e seu respectivo grupo.
Panorâmica e extensão da arbitragem voluntária nos domínios administrativo e tributário em Angola
Authors: Nunes Elisa Rangel
Published: January 2018

O texto que se segue versa sobre a arbitragem voluntária em dois domínios inseridos no plano do Direito Público: o Direito administrativo e o Direito fiscal. Trata-se de matéria que lá fora não goza de unanimidade nos diversos ordenamentos jurídicos. Contudo, onde a arbitragem voluntária penetrou nestas duas áreas do Direito público, têm sido dados passos muito marcantes e de forma progressiva. Por cá, assiste-se a uma tímida consagração legal mais recente, que contracena com normas de alguma vetustez, principalmente no domínio do contencioso administrativo. Se ao nível da consagração legal se extrai essa timidez, ao nível da sua aplicação a aridez ou o vazio é total.
Apropiación social del conocimiento: una aproximación teórica y perspectivas para Colombia
Authors: Pabón Rafael
Published: January 2018

Objetivo: El estudio tiene como  propósito elaborar  un marco teórico para la conformación de una escuela de comunicación científica orientada a la formación para la apropiación social del conocimiento.Método: Para su elaboración se ha utilizado una metodología de revisión bibliográfica descriptiva. Se  hace un repaso de las raíces teóricas del concepto y sus implicaciones en el fortalecimiento de la innovación y la ciencia como factores indispensable para el desarrollo de los países;  de igual forma, busca describir el contexto de aplicación de políticas públicas en Colombia para su consolidación.Resultados: Se ha determinado la relación interdisciplinaria entre psicopedagogía y sociología en la conformación de la idea de apropiación social, además de señalar la inconsistencia de las políticas gubernamentales en el fomento de estrategias de comunicación científica horizontal, aunque se resalta la importancia del cambio de postura en los últimos años.Conclusiones: Para comprender la relación de Colombia y Latinoamérica con la ciencia, la innovación y la tecnología, es necesario tomar a consideración gran cantidad de factores ya sea históricos, culturales, sociales e incluso geográficos. Aunque esta labor pueda resultar titánica, el primer paso para empezar a solventar el problema es señalar la clara realidad de que, en la actualidad, la región presenta aún importantes atrasos en esta materia.
CUT&RUN: Targeted in situ genome-wide profiling with high efficiency for low cell numbers v1
Authors: J. Skene Peter , Henikoff Steven
Published: January 2018

Cleavage Under Targets and Release Using Nuclease (CUT&RUN) is an epigenomic profiling strategy in which antibody-targeted controlled cleavage by micrococcal nuclease releases specific protein-DNA complexes into the supernatant for paired-end DNA sequencing. As only the targeted fragments enter into solution, and the vast majority of DNA is left behind, CUT&RUN has exceptionally low background levels. CUT&RUN outperforms the most widely used Chromatin Immunoprecipitation (ChIP) protocols in resolution, signal-to-noise, and depth of sequencing required. In contrast to ChIP, CUT&RUN is free of solubility and DNA accessibility artifacts and can be used to profile insoluble chromatin and to detect long-range 3D contacts without cross-linking. Here we present an improved CUT&RUN protocol that does not require isolation of nuclei and provides high-quality data starting with only 100 cells for a histone modification and 1000 cells for a transcription factor. From cells to purified DNA CUT&RUN requires less than a day at the lab bench. In summary, CUT&RUN has several advantages over ChIP-seq: (1) The method is performed in situ in non-crosslinked cells and does not require chromatin fragmentation or solubilization; (2) The intrinsically low background allows low sequence depth and identification of low signal genomic features invisible to ChIP; (3) The simple procedure can be completed within a day and is suitable for robotic automation; (4) The method can be used with low cell numbers compared to existing methodologies; (5) A simple spike-in strategy can be used for accurate quantitation of protein-DNA interactions. As such, CUT&RUN represents an attractive replacement for ChIPseq, which is one of the most popular methods in biological research.
Mast cells play an important regulators of acupoint sensitization via the secretion of tryptase, 5-hydroxytryptamine, and histamine v1
Authors: Ding Ning
Published: January 2018

FortySD male rats were divided into five groups randomly (n = 8per group): the normal control (N) group, the normal salinegroup (NS), the light osteoarthritis group (A), the mild osteoarthritis group (B) and the heavy osteoarthritis group (C).On day 0, the rats in the A, B and C group were injected with 0.3, 1, 3 mg MIA respectively, and rats in the NS group were injected with 50 μl of saline solution. Thetissues at the acupoints Yanglingquan (GB34), Heding (EX-LE2) and Weizhong (BL40) were dissected.The dimensionsof each tissue fragmentwere1.5 × 1.5 × 1.5 mm. The tissues were fixed in 10% neutral formalin, dehydrated, embedded in paraffin and sectioned with a 4-μm slicer. Subsequently, the sections were dewaxed, dehydrated and stained in 0.5% toluidine blue for 30 min and then washed withtap-water. the knee joints of 6 rats in each group were fixed in 10% neutral formalin after samplesof GB34, EX-LE2 and BL40 were dissected. Then, the kneejointswere placedin 5% formicacid fordemineralization, dehydrated, embedded in paraffin and sectioned with a 5-μm slicer. Subsequently, the sections were dewaxed, dehydrated, and stained in 1% fast green for 1.5 minandthen differentiated by acetic acid. Next, the sections were stained by 0.5% safranine-O for 1.5 min, differentiated by ethanol, and washed withtap-water. The tissues at GB34, EX-LE2,and BL40 were dissected, fixed in 4% paraformaldehyde for 2.5 h,and dehydrated by 25% sucrose for 2 days. A frozen 10-μm section was slicedbyafreezing microtome. Forstaining,the sections were washed in 0.1 M PB (pH=7.4) and blocked in 0.1 M PB (pH=7.4) containing 3% normal donkey serum and 0.5% Triton X-100 for 30 min. Next, the sections were treated withmouse monoclonal mast cell tryptase antibody and goat polyclonal serotonin antibody and incubated overnight at 4℃. After PB washes, the sections were exposed to Donkey Anti-Mouse IgG Alexa Fluor 488 and Donkey Anti-Goat IgG Alexa Fluor 594 for 2 hours. Subsequently, the sections were washedwith PB and stained with DAPI for 6 minutes. Afterwashing with PB, the sectionswere observedunder a confocal laser scanning microscope. Double immunohistochemical stainingusing the same staining protocol was undertaken,to examine the co-expression of mast cell tryptase and HA.
Platelet-rich plasma application in experimentally-induced skin wounds in animals: protocol for a systematic review and meta-analysis v2
Authors: Maria TAMBELLA Adolfo , Rita ATTILI Anna
Published: January 2018

Objective To determine whether the topical application of platelet-rich plasma (PRP) promotes healing in experimentally-induced full-thickness skin wounds in animals, a systematic review and meta-analysis will be performed. Methods Web of Science, Cochrane Library, PubMed, Research Gate, Cochrane Wounds Group, and Veterinary Information Network will be searched to identify randomised and not randomised controlled clinical trials comparing PRP with placebo or with other treatments in animals. Primary outcome: reduction of open wound area; secondary outcomes: healing time and number of healed cases. Effect sizes: Hedges’ g; odds ratio. This protocol was used in the following publication: https://doi.org/10.1371/journal.pone.0191093 Tambella AM, Attili AR, Dupré G, Cantalamessa A, Martin S, Cuteri V, Marcazzan S, Del Fabbro M (2018) Platelet-rich plasma to treat experimentally-induced skin wounds in animals: A systematic review and meta-analysis. PLoS ONE 13(1): e0191093. doi: 10.1371/journal.pone.0191093
Compositions of Anticancer Drug with Micellar Nanocarriers and Their Cytotoxicity
Authors: Kunitskaya Larisa , Zheltonozhskaya Tatyana , Stoika Rostyslav , Klymchuk Dmytro
Published: January 2018

Asymmetric diblock (DBC) and triblock (TBC) copolymers contained biocompatible chemically complementary polyacrylamide and poly(ethylene oxide) (PAAm-b-PEO-b-PAAm) or its monomethyl ether (MEPEO-b-PAAm), and also partially hydrolyzed triblock copolymer derivative (TBChydr) were used to create micelles of a special type. The micelles obtained are characterized by small CMCs and large values of the Gibbs micellization energy, thus indicating a high stability of DBC, TBC and TBChydr micelles in aqueous solutions and the capabilities of their use to encapsulate and deliver poorly soluble and/or toxic drugs in living organism. Morphological features and size of DBC and TBC micelles were determined by TEM. The electron images demonstrated spherical micelles of a polymolecular type, monomolecular type and separate micelle aggregates. TBC and TBChydr micelles were used to examine in vitro anticancer activity of their compositions with doxorubicin (Dox). The created micelle systems showed the enhanced cytotoxicity as compared to individual Dox against murine leukemia cells of L1210 line, murine transformed fibroblasts of L929 line and human T-leukemia cells of Jurkat line and allow to achieve a high efficacy at low Dox concentrations (0,1÷3 µg·cm-3) that opens the great prospects for essential decrease in drug dose at chemotherapy.
FOUNDATIONS OF A CONCEPTUAL MODEL OF ECONOMIC SECURITY THREAT SOURCES AT THE NATIONAL LEVEL
Authors:   Financial University under the Government of the Russian Federation, Troshin D.
Published: January 2018

The article considers the main features of sources and subjects of threats to economic security at the national level as well as their relations to the national economic system’s objects (elements). The aim is to create an ontological basis for interpreting knowledge of typical and specific sources of threats to economic security at various levels and in various nodes of the system for ensuring economic security, including in the monitoring system for economic security, as stipulated in the Strategy for Economic Security of the Russian Federation for the period until 2030. Three main threat source types are considered: natural, technogenic, anthropogenic. The character, types of objects and motives or causes of the threat sources are described. Sources of information and tasks to be resolved in the course of preparing measures to counter threat subjects are noted. A generalized ontological scheme for monitoring sources of threats was developed. The novelty of the work lies in the systematization and structuring of the knowledge of the problem field, which must be mastered for comprehensive information and knowledge provision of counteracting the sources of threats to economic security. The proposed conceptual model can serve as a basis for the creation of information, ontological, cognitive and structural-functional models, as well as heuristics for agent-based modeling of the behavior of threat sources within the framework of automated support systems and decision-making for economic security on the national level.
TECHNOLOGY OF APPLICATION OF ONTOLOGY DESIGN PATTERNS FOR ACCELERATION OF QUERIES EXECUTION IN ONTOLOGY BASED DATA ACCESS SYSTEMS
Authors:   Institute for Informatics and Mathematical Modeling of Technological Processes, The Kola Science Center of RAS, Lomov P. , Oleynik A. ,   Institute for Informatics and Mathematical Modeling of Technological Processes, The Kola Science Center of RAS
Published: January 2018

One of the known approaches to the construction of knowledge-based systems is the Ontology-based data access (OBDA) approach, which involves combining an ontology that represents a domain conceptual system and a relational database used to store data that corresponds to the concepts defined in the ontology. In this case, the ontology is used as the basis for the formation of user queries, and the database for obtaining the results of their execution. The article proposes a technology for improving the performance of queries to such systems by preliminarily database preparation, taking into account that the used ontology have been developed with using content ontology design patterns (CDP). These patterns are small ontology fragments that describes generalized situations of the domain (for example, participation in an event, the execution of some role, the parts of an object, etc.). The novelty of this technology determines the possibility of its application for a whole class of ontologies based on ontological patterns. The general principle of ontology-based data access system is considered. The description of the proposed technology, as well as its implementation for a specific ontology, and an experimental evaluation of the obtained results are described.
Nutrition and consumer education as a constituent part of global education in the light of the new education framework in state schools in southern Germany: The case of Baden-Württemberg
Authors: Angele Claudia
Published: January 2018

Nutrition and consumer education may be regarded as a constituent part of global education. It is, however, necessary to explore the connections between the specific subject didactics of nutrition and consumer education, and global education more closely within current academic discourse
if we are to understand it better. Currently, there is virtually no research or academic writing about these connections in the field of global education and global learning, apart from a few considerations addressing fair trade issues. This article follows an initial, exploratory approach
to explore the relationship between nutrition and consumer education, and global education. In this, the role of the state in formal education must be considered insofar as its educational policies on nutrition and consumer education curricula also exert an influence on the syllabus content
of nutrition and consumer education. In the new nutrition and consumer education curricula in southern Germany (specifically in Baden-Württemberg in 2016), global aspects of the syllabus are to some extent explicit, as the curriculum analysis will show. Nevertheless, a critical view of
the new curricula is necessary to understand how, and how far, it includes global learning concepts. In future, along with an exploratory approach to the relationship between nutrition and consumer education, and global education, as offered by this article, there will also be a need for
empirical subject-didactic research to clarify whether and where there are tangencies between nutrition and consumer education, and global learning in everyday teaching praxis. Empirical subject-didactic research in this field has hitherto been lacking, and thus offers a research desideratum.
A place for development education in the current Spanish and English curricula: Finding possibilities for practice
Authors: Regueiro Patricia Digón , García Rosa María Méndez , DePalma Renée , Matos Silvana Longueira
Published: January 2018

Development education has a long and well-established trajectory in terms of initiatives promoted by international organizations, national governments and civil associations, accompanied by a growing awareness of the significance of global issues. Nevertheless, an analysis of the education
policy reflected in the official Spanish and English curricula supports what Bourn (2015) has described as the current decline in development education. A comparative analysis of these curricula reveals interesting similarities and suggests a need for initiatives where teachers and schools
take the lead in developing educational practice committed to prepare students for global citizenship. Our research project, entitled Investigating the Global Dimension of Development Education: A Pilot Study in a Galician School, was largely inspired by the work of the Global Learning Programme
– England, in supporting collaborative networks to develop and implement effective teaching practices related to global issues. This participatory action research project aimed to design and put into practice a school-wide interdisciplinary teaching plan to embed development education
into everyday school practice, where the teachers served as the principle designers and developers of the educational proposals. We include a section of this teaching plan to demonstrate that, despite the limited policy support, there are possibilities for incorporating development education
into the existing curriculum.
Modern methods of the quality improvement and their application in managing of changes in a company
Authors: Gejdos Pavol
Published: January 2018

This article deals about the application of the Six Sigma methodology by using modern methods in various stages of the DMAIC improvement model. The change management of business processes in terms of quality is determined by the correct choice of methods and tools for reducing discrepancies and non-productive costs. The evaluation of selected processes of furniture production through defects per million opportunities, efficiency, capability and sigma level before the change and after the change in the quality process provides relevant information for ensuring continuous quality improvement. Implementation of assessing changes in the process is a source of information for continuous improvement of process performance. Keywords: Processes, quality improvement, Six Sigma, DMAIC, changes in processes.
Innovation and information business processes and their impact on the business performance of industrial companies in Slovakia
Authors: Rajnoha Rastislav
Published: January 2018

A business entity interested in long-term business, should realise innovations that drive business and are regarded as a tool to maintain competitiveness. A number of studies and research papers show that innovation has a significant role in the social and economic development. This paper focuses on innovation and information processes and their impact on overall business performance of industrial enterprises in Slovakia, mainly from wood-processing, automotive and engineering industries (N = 164). The business performance was expressed through Return on equity (ROE). The results point that these industrial companies from Slovakia have a strong focus on the systematic application of innovation procedures and specific business processes. Companies that use technological innovations achieve above average ROE value more than 7% (statistically significant dependence p-value < 0.05, the alpha level associated with 95% confidence level) and they need a system to formulate how innovation help them to survive and improve their performance. Keywords: Business process management, innovation, business performance, strategic management, industry.
OWNR problem with variable replenishment and inventory holding costs and quantity discounts
Authors: Åženyiğit Ercan
Published: January 2018

We consider an inventory/distribution system consisting of one warehouse and N retailers (OWNR). Warehouse replenishes its orders from external supplier and supplies all orders of retailers. The objective of this paper is to maximise supply chain benefits of the whole system. To achieve this objective SENYIGIT and AKKANâ€™s heuristic algorithm is used. We assume that demand is constant and deterministic; shortages are not allowed and lead times are negligible. Total system cost consists of order-quantity-dependent replenishment and inventory holding cost parameters, and quantity discounts are applicable. The main idea of new heuristic is to compare replenishment and inventory holding costs while manipulating the order quantity by order intervals of locations. While balance condition is searched by new version of SENYIGIT and AKKANâ€™s heuristic algorithm, quantity discounts and replenishment costs will reduce costs of whole systems. Capital limit constraint is also included to the model of objective function. The algorithm is developed for quantity discounts and 100 datasets randomly generated for the system that contains five retailers and the solutions were obtained by developed heuristic. Keywords: Supply chain management, two echelon inventory systems, integer-ratio policies, quantity discounts, heuristic method, variable cost parameters.
Regulating the social media for global relationships
Authors: Kayode-Adedeji Tolulope
Published: January 2018

The emergence of information and communications technology has opened a global platform for communication, causing lots of changes especially redefining the identity of many nations across borders. The presence of western power is becoming prominent while values and general way of life are being globally defined by the western culture. There is proof that the social media in this age are driving these changes faster than imagined. Consequently, the social media poses lots of challenges on a global level because of the differences that exist especially among the cultures. There is therefore a pressing need for some forms on the social media to protect the identity of nations, ensure security across borders and prevent nation-to-nation harassment and discrimination. This paper therefore using the Blakeâ€™s prototype proposes ways to ensure social media regulations and also identifies the possible challenges that could be faced in regulating social media network. Keywords: Social media, global relationship, prototype, information and communications technology, Internet.
Imperative in lifestyle modification: The case of diabetic
Authors: Kayode-Adedeji Tolulope
Published: January 2018

This study examined the awareness trend of diabetes and its associated lifestyle against the backdrop of increase in the rate of the disease. The rate of increase in diabetes in Africa is predicted to witness a rise from 10 to 20 m by 2015. Using the survey method, 50 respondents were interrogated. The study reveals that there is need for awareness on diabetes and healthy lifestyle. Asides promoting communication campaign through edutainment programmes on the mass media, this study suggests other ways of communicating with the public to provide the knowledge needed in order to reduce the outbreak of diabetes in Nigeria. Keywords: Diabetes, lifestyle, well-being, health, and nutrition.
Controlling anxiety and stress in ski-biathlon athletes using EmWave2
Authors: Florina Grosu Emilia
Published: January 2018

This study determines whether mental training, by applying specific techniques that influence certain psychological factors, is able to optimise performance in biathlon ski. The aim of this study is to modify dysfunctional negative emotions during competition and reduce stress and anxiety at biathlon skiing through mental training. The experimental series comprised 2 x 15 skiers from two clubs. The EmWave2device is used, which gives bio-feedback about the physiological indicators of the body, taking into account three levels of consistency such as low LH, medium MH and high HH. These were observed as: Group I â€“ statistically high significant differences between at least two levels (p < 0.01) and Group II â€“ intense statistically significant differences between at least two levels (p < 0.001). The test scores show that applying mental training lowers anxiety technique issues. The statistical differences observed between the two groups were intensely significant (p < 0.001). Keywords: Skiing - biathlon, stress, anxiety, cardiac rhythm, sport performance.
Identification of the Effective Algorithms in Language-Assessment Programmes for Autistic Children
Authors: Iuliana Barna
Published: January 2018

In the case of an autistic child, the language does not occur at the usual age, and there is no gesture communication. The first form of language describes several features: the immediate or delayed echolalia (which equates to what the interlocutor has just said), the specific monotonous and staccato prozodia, the reversal of the pronouns (you or he is designated), the poor syntax and the total or partial absence of expression emotions. The novelty of this pre-experimental study for determination and observation of speech disorders consists of structuring a series of theoretical frames (concepts, principles and models) in what concerns the speech disorders specific to preschool autistic children, as well as in providing a psycho-linguistic profile and proposing programmes and games useful in early detection of communication deficiencies. Keywords: Autistic children, evaluation, language disorders, algorithms.
TRABES ACARTELADAS DE CONCRETO REFORZADO CONTINUAS DISEÑADAS PARA FALLAR POR CORTANTE. PARTE 1: DESCRIPCIÓN DE LOS EXPERIMENTOS Y DEL COMPORTAMIENTO CÍCLICO
Authors: Tena Colunga Arturo , Urbina Californias Luis Angel , Archundia Aranda Hans I.
Published: January 2018

Se presentan resultados e interpretaciones de un programa experimental donde se han ensayando trabes acarteladas de concreto reforzado en condiciones de continuidad y sujetas a cargas cíclicas reversibles que permita estudiar su comportamiento a cortante. En este trabajo se reportan las características de los experimentos y la interpretación de los resultados de las primeras cuatro trabes acarteladas y una prismática de concreto reforzado que fueron diseñadas para fallar a cortante cuando disponen de refuerzo por cortante en la zona de las cartelas. Todos los especímenes tienen una longitud de acartelamiento de un tercio del claro libre y cubren uniformemente ángulos de acartelamiento entre cero (prismática) y diez grados. Los especímenes fueron ensayados a través de un patrón de cargas cíclicas reversibles y crecientes controladas por desplazamiento, donde se sometieron a dos ciclos completos a la misma amplitud de desplazamiento, aumentando la amplitud de los ciclos de desplazamientos conforme a un patrón geométrico establecido. Se discute el comportamiento cíclico de las trabes acarteladas en cuanto a sus patrones de agrietamiento, degradación de rigidez y resistencia y disipación de energía, y se compara con respecto a la de la trabe prismática de referencia. Los resultados de los ensayes en condiciones de continuidad permiten corroborar lo observado en los ensayes anteriores en condiciones de apoyo simple: que las trabes acarteladas de concreto reforzado son más eficientes que las trabes prismáticas, aún cuando fallan por cortante.