bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of Long-Term Water Absorption on Thermal, Morphological, and Mechanical Properties of Polypropylene-Based Composites with Agro-Waste Fillers
Authors: Zhiltsova Tatiana , Costa Andreia , Oliveira Mónica S. A.
Published: July 2024

Agro-waste fibres for polymer composite reinforcement have gained increased interest in industry and academia as a more sustainable alternative to synthetic fibres. However, natural fibre composite (NFC) hygroscopicity is still an issue that needs to be solved. This work investigates how prolonged exposure to water affects the properties of the polypropylene (PP)-based injection-moulded composites reinforced with different contents of rice husk (rh) and olive pit (op) fibres. Both rh and op composites became more hydrophilic with increased fibre charge due to the affinity of cellulose and hemicellulose OH groups. Meanwhile, lignin contributes to the protection of the composites from thermo-oxidative degradation caused by water immersion. The PPrh composites had a higher saturation water content of 1.47% (20 wt.% rh) and 2.38% (30 wt.% rh) in comparison to PPop composites with an absorption of 1.13% (20 wt.% op) and 1.59% (30 wt.% op). The tensile elastic modulus has slightly increased, at the cost of the increased saturated composites’ rigidity, in composites with 30% rh and op fibre content (up to 13%) while marginally decreasing (down to 8%) in PP30%op compared to unsaturated counterparts. A similar trend was observed for the flexural modulus, enhanced up to 18%. However, rh and op composites with 30% fibre content ruptured in bending, highlighting their fragility after hydrolytic ageing.
Comparative Efficacy of Finerenone versus Canagliflozin in Patients with Chronic Kidney Disease and Type 2 Diabetes: A Matching-Adjusted Indirect Comparison
Authors: Cherney David , Folkerts Kerstin , Mernagh Paul , Nikodem Mateusz , Pawlitschko Joerg , Rossing Peter , Hawkins Neil
Published: July 2024

This study aimed to close an evidence gap concerning the relative efficacy of finerenone versus SGLT2is in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D). Canagliflozin was selected as a proxy for the SGLT2i class. Patient-level data of two randomized controlled trials (RCTs) of finerenone (FIDELIO-DKD and FIGARO-DKD) were used alongside aggregated data from CREDENCE, an RCT of canagliflozin. To account for meaningful between-study heterogeneity between each finerenone trial and CREDENCE, a matching-adjusted indirect comparison of a range of efficacy outcomes was undertaken for each finerenone study versus CREDENCE. These results were meta-analyzed, enabling the estimation of the relative effects of finerenone against canagliflozin. For the cardiorenal composite endpoint, the hazard ratio (HR) comparing finerenone to canagliflozin was 1.07 (95% CI: 0.83 to 1.36). The corresponding HRs for all-cause mortality, end-stage kidney disease and cardiovascular death were 0.99 (95% CI: 0.73 to 1.34), 1.03 (95% CI: 0.68 to 1.55) and 0.94 (95% CI: 0.64 to 1.37), respectively. The absence of statistically significant differences was consistent throughout the main analysis and a range of sensitivity analyses. Based on this study, using a large sample of data and adjusted for meaningful differences between the baseline characteristics of the included RCTs, there was no statistically significant evidence indicating a difference in the efficacy of finerenone compared to canagliflozin in the treatment of CKD in patients with T2D.
Dynamic Response Analysis of a Subsea Rigid M-Shaped Jumper under Combined Internal and External Flows
Authors: Li Guangzhao , Li Wenhua , Lin Shanying , Han Fenghui , Zhou Xingkun
Published: July 2024

To analyze the dynamic response of a rigid M-shaped jumper subjected to combined internal and external flows, a one-way coupled fluid–structure interaction process is applied. First, CFD simulations are conducted separately for the internal and external fluid domains. The pressure histories on the inner and outer walls are exported and loaded into the finite element model using inverse distance interpolation. Then, FEA is performed to determine the dynamic response, followed by a fatigue assessment based on the obtained stress data. The displacement, acceleration, and stress distribution along the M-shaped jumper are obtained. External flow velocity dominates the displacements, while internal flow velocity dominates the vibrations and stresses. The structural response to the combined effect of internal and external flows, plus the response to gravity alone, equals the sum of the structural responses to internal flow alone and external flow alone. Fatigue damage is calculated for the bend exhibiting the most intense vibration and higher stress levels, and the locations with significant damage correspond to areas with high maximum von Mises stress. This paper aims to evaluate multiple flow fields acting simultaneously on subsea pipelines and to identify the main factors that provide valuable information for their design, monitoring, and maintenance.
Challenges for Customs Risk Management Today: A Literature Review
Authors: Karklina-Admine Sandra , Cevers Aldis , Kovalenko Arturs , Auzins Armands
Published: July 2024

Changes and uncertainty in the customs operating environment and the growth of trade and travel volumes have affected how customs administrations manage and approach their tasks. As a result of technological development, the role of customs in border control has changed dramatically. Thus, the massive volume of goods, the way they are traded worldwide, and the speed of such transactions create additional fiscal, security, financial, and safety risks, affecting the resources available to customs services. The current geopolitical situation has significantly impacted the role of customs services. The topic is relevant to simultaneously assure both the quality of the services provided by the customs and compliance with the requirements set in the framework of limited resources. This study focuses on customs risk management (CRM) issues. It acknowledges that the customs services must continuously improve their operational methods, including promoting a more structured, integrated, and systematic way to manage customs risks. Based on the literature review, we examine the CRM-related challenges and how scholars address them in the scientific literature. This study aims to identify and analyse the contemporary challenges in CRM from its effectiveness point of view. We employ a systematic literature review, searching in most recognised databases and covering the period of 2005–2024. We follow this with a qualitative content analysis and synthesis, summarising and discussing the study results. We identify and discuss relevant key factors contributing to effective CRM. Finally, we conclude with the implications of the findings for CRM practice and policy, as well as with various potential developments in CRM that we suggest for further work.
Beyond Compliance: How ESG Reporting Influences the Cost of Capital in UK Firms
Authors: Moussa Ahmed Saber , Elmarzouky Mahmoud
Published: July 2024

This research examines the effect of ESG disclosure on the cost of capital for non-financial firms in the UK, indexed by the FTSE All-Share Index, during the period from 2014 to 2018. Using multivariate analysis with ordinary least squares (OLS), fixed effects, robust regression, and Tobit models, this research assesses the effect of ESG reporting, governance, and the cost of capital, including robustness checks using an alternative ESG indicator, the environmental pillar score. Contrary to expectations, ESG reporting is positively associated with the cost of capital. However, corporate governance moderates this relationship, weakening the positive correlation and reversing it to a negative association for firms with strong governance practices, consistent with the hypotheses. This research also finds that firm size, liquidity, profitability, and leverage, positively affect the cost of capital, while board size, independent board composition, audit committee independence, and auditor type do not significantly influence it. Notably, non-executive directors on the audit committee have a significant negative effect on the cost of capital. These findings are valuable for investors, companies, regulators, auditors, policymakers, and the academic and research community. Specifically, for investors, this study provides insights into how ESG disclosures can influence investment risks and returns, highlighting the importance of robust corporate governance. Companies can leverage these insights to enhance their governance practices and optimize their capital costs. Regulators and policymakers can use the findings to develop guidelines that encourage transparent ESG reporting and strong governance frameworks, thereby improving market stability and investor confidence. Auditors can utilize the results to better understand the effect of non-financial reporting on financial metrics, helping to provide more accurate audits and assessments. These findings inform investors, companies, regulators, auditors, and academia, in fostering a more sustainable and transparent financial environment.
The Evolution of Price Discrimination in E-Commerce Platform Trading: A Perspective of Platform Corporate Social Responsibility
Authors: Ma Ying , Guo Xiaodong , Su Weihuan , Fu Guo
Published: July 2024

The widespread use of data in e-commerce has facilitated the implementation of different pricing strategies for platforms and merchants. However, the excessive use of algorithms for differential pricing has sparked discussions about fairness and price discrimination, disrupting the platform trading system. To address this challenge, we adopt an evolutionary game approach to analyze the evolutionary strategies of all parties from the perspective of platform CSR. It is based on a special type of e-commerce platform trading in which major merchants have data analytics capabilities. We construct an evolutionary game model considering reputation and punishment, explore the impact of different situations and factors on the system’s evolutionary stability strategy, and conduct its verification via simulation experiments. The results show that long-term reputation is the internal driving force for platforms to fulfill responsibilities. The joint punishment of collusion is the external binding force. Consumer complaints are key to restricting merchants’ integrity operation. Moreover, penalties imposed by e-commerce platforms can help eradicate price discrimination. This study provides a new perspective to solve price discrimination in the digital era. Measures based on reputation and punishment can guide platforms to fulfill other social responsibilities.
Management Impacts on Non-Native Smooth Brome (Bromus inermis Leyss.) Control in a Native Fescue Grassland in Canada
Authors: Brown Debra J. , Dhar Amalesh , Naeth M. Anne
Published: July 2024

Native fescue grassland degradation and reductions in plant species diversity due to smooth brome (Bromus inermis Leyss.) invasion and dominance have far ranging consequences for both human and ecological systems. A study was undertaken to reduce smooth brome which was invading foothills fescue grassland in Canada and displacing native species. Sheep and cattle grazing, mowing, glyphosate, and burning were applied to control smooth brome-dominant grasslands over three growing seasons. Defoliation (5 to 10 cm, 2 to 4 times) did not reduce smooth brome tiller density, etiolated regrowth, or total non-structural carbohydrates; however, the three heaviest defoliation treatments (sheep 3×, cattle 3×, mowing 4×) reduced smooth brome composition by year 3. Repeated glyphosate wicking (1× year 1, 2× year 2) was the most effective treatment and reduced smooth brome tiller density by 50% by year 3. Early-spring burning, as smooth brome began to grow, stressed the plants and reduced tiller density. Kentucky bluegrass (Poa pratensis L.), the subdominant species, increased in all treatments except the reference; thus, reducing smooth brome may result in another undesirable species becoming dominant.
The Enlhet Revelative
Authors: Kalisch Hannes , Salanova Andrés Pablo
Published: July 2024

This paper describes the Enlhet revelative nooka’ and proposes a unified semantic analysis for it. Prima facie, nooka’ has evidential, mirative, and temporal nuances in its meaning. Against this, we establish that the core meaning of nooka’ is a change in epistemic state, and that the particle is not associated to specific sources of evidence nor to contradicting a previous expectation. The evidential properties of the particle arise from interactions between the time of the event and evidence acquisition time, while any mirative properties of nooka’ are occasional concomitants, but are not necessarily associated with the particle. We show how the evidence acquisition time implicit in nooka’ differs from the main narrative time. Our analysis characterizes nooka’ as a revelative, a category that has been identified in various other languages, but which is still poorly understood.
Exploring Active Case Detection Approaches for Leprosy Diagnosis in Varied Endemic Settings: A Comprehensive Scoping Review
Authors: Brown Heynes , Fastenau Anil , Penna Srilekha , Saunderson Paul , Klabbers Gonnie
Published: July 2024

(1) Background: The global burden of leprosy is not shared equally; with the majority of cases being diagnosed in Brazil, India, and Indonesia. Understanding the methods of active case detection (ACD) used in high and low endemic regions is vital for the development of future screening programs. (2) Methods: A systematic search of three databases, PubMed, Embase and Web of Science, was conducted for English language papers, published since the year 2000, which discussed the use of active case detection methods for leprosy screening. The paper utilised the Integrated Screening Action Model (I-SAM) as a tool for the analysis of these methods. (3) Results: 23 papers were identified from 11 different countries. The papers identified 6 different methods of active case detection: Household contact/social contact identification; door-to-door case detection; screening questionnaire distribution; rapid village surveys; school-based screening; and prison-based screening. 15 were located in high endemic regions and 8 of these were located in low endemic regions. (4) Conclusions: For selecting the appropriate methods of active case finding, the leprosy endemicity must be taken into consideration. The findings contribute to policy decision making allowing for more successful future leprosy case detection programs to be designed, ultimately reducing the global burden of the disease, and achieving the WHO’s aim of zero leprosy.
Synthesis, Characterization, and Docking Study of a Novel Indole Derivative Containing a Tosyl Moiety as Anti-Oxidant Agent
Authors: Chihab Abdelali , El Brahmi Nabil , El Kazzouli Saïd
Published: July 2024

Indole derivatives are key components of natural products and possess a wide range of biological and pharmaceutical applications. Here, we present the synthesis of a new indole derivative, namely 2-(1-ethyl-5-nitro-1H-indole-7-carbonyl)butyl 4-methylbenzenesulfonate. The structural elucidation of this compound was accomplished through comprehensive spectroscopic analysis, including Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and high-resolution mass spectrometry (HRMS). Our molecular docking study revealed that this compound exhibits strong affinity towards tyrosinase, making it a promising candidate as an antioxidant agent.
Effect of Degradation of Polylactic Acid (PLA) on Dynamic Mechanical Response of 3D Printed Lattice Structures
Authors: Hedayati Reza , Alavi Melikasadat , Sadighi Mojtaba
Published: July 2024

Material-extrusion-based 3D printing with polylactic acid (PLA) has transformed the production of lightweight lattice structures with a high strength-to-weight ratio for various industries. While PLA offers advantages such as eco-friendliness, affordability, and printability, its mechanical properties degrade due to environmental factors. This study investigated the impact resistance of PLA lattice structures subjected to material degradation under room temperature, humidity, and natural light exposure. Four lattice core types (auxetic, negative-to-positive (NTP) gradient in terms of Poisson’s ratio, positive-to-negative (PTN) gradient in terms of Poisson’s ratio, and honeycomb) were analyzed for variations in mechanical properties due to declines in yield stress and failure strain. Mechanical testing and numerical simulations at various yield stress and failure strain levels evaluated the degradation effect, using undegraded material as a reference. The results showed that structures with a negative Poisson’s ratio exhibited superior resistance to local crushing despite material weakening. Reducing the material’s brittleness (failure strain) had a greater impact on impact response compared to reducing its yield stress. This study also revealed the potential of gradient cores, which exhibited a balance between strength (maintaining similar peak force to auxetic cores around 800 N) and energy absorption (up to 40% higher than auxetic cores) under moderate degradation (yield strength and failure strain at 60% and 80% of reference values). These findings suggest that gradient structures with varying Poisson’s ratios employing auxetic designs are valuable choices for AM parts requiring both strength and resilience in variable environmental conditions.
Differentiation between Hydrolytic and Thermo-Oxidative Degradation of Poly(lactic acid) and Poly(lactic acid)/Starch Composites in Warm and Humid Environments
Authors: Goetjes Victoria , Zarges Jan-Christoph , Heim Hans-Peter
Published: July 2024

For the application of poly(lactic acid) (PLA) and PLA/starch composites in technical components such as toys, it is essential to know their degradation behavior under relevant application conditions in a hydrothermal environment. For this purpose, composites made from PLA and native potato starch were produced using twin-screw extruders and then processed into test specimens, which were then subjected to various one-week ageing processes with varying temperatures (23, 50, 70, 90 °C) and humidity levels (10, 50, 75, 90%). This was followed by mechanical characterization (tensile test) and identification of degradation using Gel Permeation Chromatography (GPC), Thermogravimetric Analysis (TGA), Fourier Transform Infrared Spectroscopy (FTIR), and Nuclear Magnetic Resonance spectroscopy (NMR). With increasing temperature and humidity, there was a clear degradation of the PLA, which could be reduced or slowed down by adding 50 wt.% starch, due to increased crystallinity. Hydrolysis was identified as the main degradation mechanism for PLA and PLA/starch composites, especially above the glass transition temperature, with thermo-oxidative degradation also playing a subordinate role. Both hydrolytic degradation and thermo-oxidative degradation led to a reduction in mechanical properties such as tensile strength.
A New Subclass of H-Matrices with Applications
Authors: Cvetković Dragana , Vukelić Đorđe , Doroslovački Ksenija
Published: July 2024

The diagonal dominance property has been applied in many different ways and has proven to be very useful in various research areas. Its generalization, also known under the name H-matrix property, can be applied and produce significant benefits in economic theory, environmental sciences, epidemiology, neurology, engineering, etc. For example, it is known that the (local) stability of a (nonlinear) dynamic system is ensured if the (Jacobian) matrix belongs to the H-matrix class, and all its diagonal elements are negative. However, checking the H-matrix property itself is too expensive (from a computational point of view), so it is always worth investing effort in finding new subclasses of H-matrices, defined by relatively simple and practical conditions. Here, we will define a new subclass, which is closely related to the Euclidean vector norm, give some possible applications of this new class, and consider its relationship to some known subclasses.
Energy-Efficient Task Offloading in Wireless-Powered MEC: A Dynamic and Cooperative Approach
Authors: He Huaiwen , Zhou Chenghao , Huang Feng , Shen Hong , Li Shuangjuan
Published: July 2024

Mobile Edge Computing (MEC) integrated with Wireless Power Transfer (WPT) is emerging as a promising solution to reduce task delays and extend the battery life of Mobile Devices (MDs). However, maximizing the long-term energy efficiency (EE) of a user-cooperative WPT-MEC system presents significant challenges due to uncertain load dynamics at the edge MD and the time-varying state of the wireless channel. In this paper, we propose an online control algorithm to maximize the long-term EE of a WPT-MEC system by making decisions on time allocations and transmission powers of mobile devices (MDs) for a three-node network. We formulate a stochastic programming problem considering the stability of network queues and time-coupled battery levels. By leveraging Dinkelbach’s method, we transform the fractional optimal problem into a more manageable form and then use the Lyapunov optimization technique to decouple the problem into a deterministic optimization problem for each time slot. For the sub-problem in each time slot, we use the variable substitution technique and convex optimization theory to convert the non-convex problem into a convex problem, which can be solved efficiently. Extensive simulation results demonstrate that our proposed algorithm outperforms baseline algorithms, achieving a 20% improvement in energy efficiency. Moreover, our algorithm achieves an [O(1/V),O(V)] trade-off between EE and network queue stability.
Invariants for Second Type Almost Geodesic Mappings of Symmetric Affine Connection Space
Authors: Vesić Nenad O. , Simjanović Dušan J. , Randjelović Branislav M.
Published: July 2024

This paper presents the results concerning a space of invariants for second type almost geodesic mappings. After discussing the general formulas of invariants for mappings of symmetric affine connection spaces, based on these formulas, invariants for second type almost geodesic mappings of symmetric affine connection spaces and Riemannian spaces are obtained, as well as their mutual connection. Also, one invariant of Thomas type and two invariants of Weyl type for almost geodesic mappings of the second type were attained.
Note on Intuitionistic Fuzzy Metric-like Spaces with Application in Image Processing
Authors: Došenović Tatjana , Rakić Dušan , Ralević Nebojša , Carić Biljana
Published: July 2024

Recently, the fixed-point theorem for fuzzy contractive mappings has been investigated within the framework of intuitionistic fuzzy metric-like spaces. This interesting topic was explored through the utilization of G-Cauchy sequences as defined by Grabiec. The aim of this study is to enhance the aforementioned results in a few aspects. Initially, the proof of the fixed-point theorem is simplified and condensed, allowing for potential generalization to papers focusing on similar fixed-point analyses. Furthermore, instead of G-Cauchy sequences, the classical Cauchy sequences proposed by George and Veeramani are examined, incorporating an additional condition on the fuzzy metric. Within this context, a solution to an old unresolved question posed by Gregory and Sapena is provided. The findings are reinforced by relevant examples. Finally, the introduced fuzzy metrics are applied to the field of image processing.
Multi-Class Hypersphere Anomaly Detection Based on Edge Outlier Exposure Set and Margin
Authors: Gao Min , Liu Xuan , Xu Di , Yang Guowei
Published: July 2024

Currently, the decision boundary of the multi-class anomaly detection algorithm based on deep learning does not sufficiently capture the positive class region, posing a risk of abnormal sample features falling into the domain of normal sample features and potentially leading to misleading outcomes in practical applications. In response to the above problems, this paper proposes a new method called multi-class hypersphere anomaly detection (MMHAD) based on the edge outlier exposure set and margin. The method aims to utilize convolutional neural networks for joint training of all normal object classes, identifying a shared set of outlier exposures, learning compact identification features, and setting appropriate edge parameters to guide the model in mapping outliers outside the hypersphere. This approach enables more comprehensive detection of various types of exceptions. The experiments demonstrate that the algorithm is superior to the most advanced baseline method, with an improvement of 26.0%, 8.2%, and 20.1% on CIFAR-10 and 14.8%, 12.0%, and 20.1% on FMNIST in the cases of (2/8), (5/5), and (9,1), respectively. Furthermore, we investigate the challenging (2/18) case on CIFAR-100, where our method achieves approximately 17.4% AUROC gain. Lastly, for a recycling waste dataset with the (4/1) case, our MMHAD yields a notable 22% enhancement in performance. Experimental results show the effectiveness of the proposed model in multi-classification anomaly detection.
A Discrete Hamilton–Jacobi Theory for Contact Hamiltonian Dynamics
Authors: Esen Oğul , Sardón Cristina , Zajac Marcin
Published: July 2024

In this paper, we propose a discrete Hamilton–Jacobi theory for (discrete) Hamiltonian dynamics defined on a (discrete) contact manifold. To this end, we first provide a novel geometric Hamilton–Jacobi theory for continuous contact Hamiltonian dynamics. Then, rooting on the discrete contact Lagrangian formulation, we obtain the discrete equations for Hamiltonian dynamics by the discrete Legendre transformation. Based on the discrete contact Hamilton equation, we construct a discrete Hamilton–Jacobi equation for contact Hamiltonian dynamics. We show how the discrete Hamilton–Jacobi equation is related to the continuous Hamilton–Jacobi theory presented in this work. Then, we propose geometric foundations of the discrete Hamilton–Jacobi equations on contact manifolds in terms of discrete contact flows. At the end of the paper, we provide a numerical example to test the theory.
Macroeconomic Impacts of College Expansion on Structural Transformation and Energy Economy in China: A Heterogeneous Agent General Equilibrium Approach
Authors: Huang Ziyao , Yang Fang
Published: July 2024

In this study, we construct heterogeneous agent general equilibrium models to investigate the relative importance of labor endowment in driving structural transformation. We aim to explore the following question: beyond the demand-side and supply-side structural transformation driving forces extensively studied in the existing literature, does labor, as a crucial endowment, play a pivotal role in facilitating structural transformation and the energy economy? In contrast to the prevalent partial equilibrium analyses, our study employs a general equilibrium framework to conduct a policy evaluation of college expansion, a significant policy that has altered the labor endowment structure in China. Our approach begins with developing a multi-sector model that integrates a nested CES production function and incorporates workers with different skill levels to assess the macroeconomic impact of college expansion on structural transformation. We calibrate the base model to reflect labor allocations across sectors and skill levels using the simulated method of moments (SMM), ensuring that the model-generated data align closely with actual labor allocation data. Utilizing this calibrated model, we perform counterfactual experiments to assess the impact and relative importance of the college expansion policy. Our counterfactual analysis demonstrates that the policy has resulted in an average decrease of 7.7% in labor allocation in the agricultural sector, alongside an average increase of 8.9% in the industry sector and 28.7% in the services sector. These results highlight the significant, yet often overlooked, contribution of labor in endowment-driven structural transformation. Furthermore, we extend the base model by constructing an industry-level heterogeneous agent general equilibrium model, enabling us to pinpoint which industries have developed as a result of the college expansion policy and recalibrate it at the industry level. This approach allows us to analyze the impact of changes in labor endowment on the energy economy. Counterfactual experiments conducted show that the college expansion policy has prompted a labor shift from industries with low energy efficiency and high pollution to high-end services. This macroeconomic pattern of structural transformation suggests that the college expansion policy has facilitated a transition toward a low-carbon economy by reducing dependency on high energy-consuming industries and promoting high-end services.
Variation in Flow Characteristics of Molten Baths at Different Blowing Stages in the Converter
Authors: Lv Ming , Hao Yijie , Hou Fuqing , Chen Shuangping , Guo Hongmin , Zhang Zhaohui
Published: July 2024

The metallurgical tasks at different stages of converter blowing are different. The process operation and physical properties of molten baths are also different. It is very important to determine the flow characteristics of molten baths at different blowing stages for optimizing process operation. In this paper, a three-dimensional, full-scale model of a 120 t top–bottom combined blowing converter is established. Based on the parameters of oxygen lance position, bath temperature, bottom blowing intensity, and bath physical properties at different blowing stages, the changes in bath flow field, turbulent kinetic energy, impact depth, impact area, and wall shear force with blowing process are studied. The results show that at the initial stage of blowing, the lance position is high, the impact depth of the molten bath is 0.23 m, the impact area is 5.06 m2, the dead zone area of the longitudinal section is 0.40 m2, and the high-speed zone area is 2.73 m2. As the blowing time increases, the lance position decreases, the impact depth of the molten bath increases, the impact area decreases, and the internal velocity of the molten bath increases. In the later stage of tuyere blowing, the lance level decreases to its lowest, the impact depth increases to 0.42 m, the impact area decreases to 2.83 m2, the dead zone area of longitudinal section decreases to 0.18 m2, and the high-speed area increases to 3.34 m2. The area with the highest wall shear stress is situated within the gas–slag–metal three-phase region, where the lining experiences the most significant erosion. The fluctuation in the slag–metal interface is small, and the wall shear force is 2.80 Pa at the initial stage of blowing. From the early to late stages of blowing, the lance position decreases, the fluctuation range of the slag–metal interface increases, and the erosion of the furnace lining increases. In the later stage of blowing, the maximum wall shear force is 3.81 Pa.
Oligomalt, a New Slowly Digestible Carbohydrate, Reduces Post-Prandial Glucose and Insulin Trajectories Compared to Maltodextrin across Different Population Characteristics: Double-Blind Randomized Controlled Trials in Healthy Individuals, People with Obesity, and People with Type 2 Diabetes
Authors: Johansen Odd Erik , Neutel Joel , Gupta Sanjay , Mariani Barbara , Ufheil Gerhard , Perrin Emilie , Rytz Andreas , Lahiry Anirban , Delodder Frederik , Lerea-Antes Jaclyn , Ocampo Naomi , von Eynatten Maximilian
Published: July 2024

We assessed the glucometabolic effects of oligomalt, a novel fully slowly digestible carbohydrate, compared with maltodextrin, in cross-over randomized controlled trials (NCT05058144; NCT05963594) involving healthy volunteers (HV), people with overweight or obesity (PwO), and people with type 2 diabetes (T2D). We tested 33 g and/or 50 g of oligomalt/maltodextrin, which were dissolved in 300 mL of water and consumed after fasting in the morning. The primary exploratory endpoint was the incremental area under the curve (iAUC) for postprandial glucose, assessed by frequent blood sampling over 3 h. Insulin levels were also assessed. In the HV cohort, a 4 h hydrogen breath test was performed with 15 g of inulin as a positive control. Analysis was performed by a mixed model. Oligomalt elicited a lower post-prandial glucose response compared to maltodextrin in HV (50 g, n = 15 [7 women], mean age/BMI 31 years/22.6 kg/m2), in PwO (33 g and 50 g, n = 26 [10 women], age/BMI 44 years/29.9 kg/m2, mean HbA1c 5.3%), and in people with T2D (50 g, n = 22 [13 women], age/BMI 61 years/31.8 kg/m2, HbA1c 7.4%), with significant reductions observed in PwO and T2D for the 0–1 h window (HV: −19% [p = 0.149]/PwO33g-38% [p = 0.0002]/PwO50g-28% [p = 0.0027]/T2D-38% [p < 0.0001]; the 0–2 h window (HV: −17% [p = 0.311]/PwO33g-34% [p = 0.0057]/PwO50g-21% [p = 0.0415]/T2D-37% [p < 0.0001]), and the 0–3 h window (HV: −15% [p = 0.386]/PwO33g-30% [p = 0.0213]/PwO50g0−19% [p = 0.0686]/T2D−37% [p = 0.0001]). The post-prandial insulin response was significantly lower, by 38–60%, across all populations, dose, and time points, with oligomalt. In HV, the breath-hydrogen pattern was comparable between oligomalt and maltodextrin, but increased significantly with inulin. These data support the glucometabolic advantages of oligomalt over maltodextrin, hence confirming it as a healthier carbohydrate, and underscoring its full digestibility. This therefore opens up the possibility for the incorporation of oligomalt in relevant food products/matrices.
Metabolomic Profiling of Adipose Tissue in Type 2 Diabetes: Associations with Obesity and Insulin Resistance
Authors: Mathioudaki Argyri , Fanni Giovanni , Eriksson Jan W. , Pereira Maria J.
Published: July 2024

The global prevalence of Type 2 Diabetes (T2D) poses significant public health challenges due to its associated severe complications. Insulin resistance is central to T2D pathophysiology, particularly affecting adipose tissue function. This cross-sectional observational study investigates metabolic alterations in subcutaneous adipose tissue (SAT) associated with T2D to identify potential therapeutic targets. We conducted a comprehensive metabolomic analysis of SAT from 40 participants (20 T2D, 20 ND-T2D), matched for sex, age, and BMI (Body Mass Index). Metabolite quantification was performed using GC/MS and LC/MS/MS platforms. Correlation analyses were conducted to explore associations between metabolites and clinical parameters. We identified 378 metabolites, including significant elevations in TCA cycle (tricarboxylic acid cycle) intermediates, branched-chain amino acids (BCAAs), and carbohydrates, and a significant reduction in the nucleotide-related metabolites in T2D subjects compared to those without T2D. Obesity exacerbated these alterations, particularly in amino acid metabolism. Adipocyte size negatively correlated with BCAAs, while adipocyte glucose uptake positively correlated with unsaturated fatty acids and glycerophospholipids. Our findings reveal distinct metabolic dysregulation in adipose tissue in T2D, particularly in energy metabolism, suggesting potential therapeutic targets for improving insulin sensitivity and metabolic health. Future studies should validate these findings in larger cohorts and explore underlying mechanisms to develop targeted interventions.
Biofilm Production and Its Implications in Pediatrics
Authors: Principi Nicola , Esposito Susanna
Published: July 2024

Biofilms, aggregates of bacteria enclosed in a self-produced matrix, have been implicated in various pediatric respiratory infections, including acute otitis media (AOM), otitis media with effusion (OME), adenoiditis, protracted bacterial bronchitis, and pulmonary exacerbations in cystic fibrosis. These infections are prevalent in children and often associated with biofilm-producing pathogens, leading to recurrent and chronic conditions. Biofilms reduce antibiotic efficacy, contributing to treatment failure and disease persistence. This narrative review discusses biofilm production by respiratory pathogens such as Streptococcus pneumoniae, non-typeable Haemophilus influenzae, Pseudomonas aeruginosa, and Staphylococcus aureus. It examines their mechanisms of biofilm formation, antibiotic resistance, and the challenges they present in clinical treatment. Various antibiofilm strategies have shown promise in vitro and in animal studies, including the use of N-acetylcysteine, enzymes like dispersin B, and agents disrupting quorum sensing and biofilm matrix components. However, their clinical application, particularly in children, remains limited. Traditional treatments for biofilm-associated diseases have not significantly evolved, even with biofilm detection. The transition from experimental findings to clinical practice is complex and requires robust clinical trials and standardized biofilm detection protocols. Addressing biofilms in pediatric respiratory infections is crucial for improving treatment outcomes and managing recurrent and chronic diseases effectively.
Resuscitation Promotion Factor: A Pronounced Bacterial Cytokine in Propelling Bacterial Resuscitation
Authors: Li Xinxin , Ren Qing , Sun Zhanbin , Wu Yanan , Pan Hanxu
Published: July 2024

While confronted with unfavorable growth conditions, bacteria may transform into the dormant state, such as viable but nonculturable (VBNC) state, which is a reversible state characterized by low metabolic activity and lack of division. These dormant cells can be reactivated through the influence of the resuscitation promoting factor (Rpf) family, which are classified as autocrine growth factors and possess peptidoglycan hydrolase activities. To date, with the significant resuscitation or growth promotion ability of Rpf, it has been extensively applied to increasing bacterial diversity and isolating functional microbial species. This review provides a comprehensive analysis of the distribution, mode of action, and functional mechanisms of Rpf proteins in various bacterial species. The aim is to create opportunities for decoding microbial communities and extracting microbial resources from real samples across different research fields.
IAA Synthesis Pathway of Fitibacillus barbaricus WL35 and Its Regulatory Gene Expression Levels in Potato (Solanum tuberosum L.)
Authors: Li Xiaoyu , Tao Huan , Wang Shisong , Zhang Di , Xiong Xingyao , Cai Yanfei
Published: July 2024

Indole-3-acetic acid (IAA), as an important regulator of potato growth, seriously affects the growth and yield of potato. Although many studies have reported that IAA-producing Bacillus can promote plant growth, little research has been conducted on its synthesis pathway and molecular mechanisms. In this study, an IAA-producing strain WL35 was identified as Fitibacillus barbaricus, and its yield was 48.79 mg·L−1. The results of the pot experiments showed that WL35 significantly increased plant height, stem thickness, chlorophyll content, and number of leaves of potato plants by 31.68%, 30.03%, 32.93%, and 36.59%, respectively. In addition, in the field experiments, WL35-treated plants increased commercial potato yield by 16.45%, vitamin C content by 16.35%, protein content by 75%, starch content by 6.60%, and the nitrogen, phosphorus, and potassium accumulation by 9.98%, 12.70%, and 26.76%, respectively. Meanwhile, the synthetic pathway of WL35 was found to be dominated by the tryptophan-dependent pathway, the IAM, TAM, and IPA pathways worked together, and the pathways that played a role at different times were different. Furthermore, RNA-seq analysis showed that there were a total of 2875 DEGs regulated in the samples treated with WL35 seed dressing compared with the CK, of which 1458 genes were up-regulated and 1417 genes were down-regulated. Potato roots express differential genes enriched in processes such as carbohydrate metabolism processes and cellular polysaccharide metabolism, which regulate potato plant growth and development. The above results provide a theoretical basis for the further exploration of the synthesis pathway of IAA and its growth-promoting mechanism in potato.
Functional Characterization of Ao4g24: An Uncharacterized Gene Involved in Conidiation, Trap Formation, Stress Response, and Secondary Metabolism in Arthrobotrys oligospora
Authors: Zhu Lirong , Zhu Meichen , Li Xuemei , Shen Yanmei , Duan Shipeng , Yang Jinkui
Published: July 2024

Arthrobotrys oligospora is a typical nematode-trapping (NT) fungus, which can secrete food cues to lure, capture, and digest nematodes by triggering the production of adhesive networks (traps). Based on genomic and proteomic analyses, multiple pathogenic genes and proteins involved in trap formation have been characterized; however, there are numerous uncharacterized genes that play important roles in trap formation. The functional studies of these unknown genes are helpful in systematically elucidating the complex interactions between A. oligospora and nematode hosts. In this study, we screened the gene AOL_s00004g24 (Ao4g24). This gene is similar to the SWI/SNF chromatin remodeling complex, which was found to play a potential role in trap formation in our previous transcriptome analysis. Here, we characterized the function of Ao4g24 by gene disruption, phenotypic analysis, and metabolomics. The deletion of Ao4g24 led to a remarkable decrease in conidia yield, trap formation, and secondary metabolites. Meanwhile, the absence of Ao4g24 influenced the mitochondrial membrane potential, ATP content, autophagy, ROS level, and stress response. These results indicate that Ao4g24 has crucial functions in sporulation, trap formation, and pathogenicity in NT fungi. Our study provides a reference for understanding the role of unidentified genes in mycelium growth and trap formation in NT fungi.
Whole Genome Sequencing of Bacillus velezensis AMR25, an Effective Antagonist Strain against Plant Pathogens
Authors: Ananev Alexey A. , Ogneva Zlata V. , Nityagovsky Nikolay N. , Suprun Andrey R. , Kiselev Konstantin V. , Aleynova Olga A.
Published: July 2024

The most serious problems for cultivated grapes are pathogenic microorganisms, which reduce the yield and quality of fruit. One of the most widespread disease of grapes is “gray mold”, caused by the fungus Botrytis cinerea. Some strains of Bacillus, such as Bacillus halotolerans, Bacillus amyloliquefaciens, and Bacillus velezensis, are known to be active against major post-harvest plant rots. In this study, we showed that the endophytic bacteria B. velezensis strain AMR25 isolated from the leaves of wild grapes Vitis amurensis Rupr. exhibited antimicrobial activity against grape pathogens, including B. cinerea. The genome of B. velezensis AMR25 has one circular chromosome with a length of 3,909,646 bp. with 3689 open reading frames. Genomic analysis identified ten gene clusters involved in the nonribosomal synthesis of polyketides (macrolactin, bacillene, and difficidin), lipopeptides (surfactin, fengycin, and bacillizin), and bacteriocins (difficidin). Also, the genome under study contains a number of genes involved in root colonization, biofilm formation, and biosynthesis of phytohormones. Thus, the endophytic bacteria B. velezensis strain AMR25 shows great promise in developing innovative biological products for enhancing plant resistance against various pathogens.
Characterization of WO3/Silicone Rubber Composites for Hydrogen-Sensitive Gasochromic Application
Authors: Wang Lin , Yang Ke , Yu Ping , Liu Huan , Cheng Qingli , Yu Anfeng , Liu Xinmei , Yang Zhe
Published: July 2024

WO3 and silicone rubber (SR)-based gasochromic composites were fabricated to detect hydrogen leaks at room temperature. WO3 rod-like nanostructures were uniformly distributed in the SR matrix, with a particle size of 60–100 nm. The hydrogen permeability of these composites reached 1.77 cm3·cm/cm2·s·cmHg. At a 10% hydrogen concentration, the visible light reflectance of the composite decreased 49% during about 40 s, with a color change rate of 6.4% s−1. Moreover, the composite detected hydrogen concentrations as low as 0.1%. And a color scale was obtained for easily assessing hydrogen concentrations in the environment based on the color of composites. Finally, the composite materials as disposable sensors underwent testing at several Sinopec hydrogen refueling stations.
Biological Nano-Agrochemicals for Crop Production as an Emerging Way to Address Heat and Associated Stresses
Authors: Prokisch József , Ferroudj Aya , Labidi Safa , El-Ramady Hassan , Brevik Eric C.
Published: July 2024

Climate change is a global problem facing all aspects of the agricultural sector. Heat stress due to increasing atmospheric temperature is one of the most common climate change impacts on agriculture. Heat stress has direct effects on crop production, along with indirect effects through associated problems such as drought, salinity, and pathogenic stresses. Approaches reported to be effective to mitigate heat stress include nano-management. Nano-agrochemicals such as nanofertilizers and nanopesticides are emerging approaches that have shown promise against heat stress, particularly biogenic nano-sources. Nanomaterials are favorable for crop production due to their low toxicity and eco-friendly action. This review focuses on the different stresses associated with heat stress and their impacts on crop production. Nano-management of crops under heat stress, including the application of biogenic nanofertilizers and nanopesticides, are discussed. The potential and limitations of these biogenic nano-agrochemicals are reviewed. Potential nanotoxicity problems need more investigation at the local, national, and global levels, as well as additional studies into biogenic nano-agrochemicals and their effects on soil, plant, and microbial properties and processes.
The Role of Combined Muscle Ultrasound and Bioimpedentiometry Parameters for Sarcopenia Diagnosis in a Population of Hospitalized Older Adults
Authors: Zanotelli Alfredo , Rossi Andrea P. , Del Monte Letizia , Vantini Gianluca , Stabile Giovanni , Urbani Silvia , Giani Anna , Zoico Elena , Babbanini Alessio , Fantin Francesco , Zamboni Mauro , Mazzali Gloria
Published: July 2024

Background: For the study of quantitative and qualitative muscle parameters, ultrasound and bioelectric impedance analysis are reliable, non-invasive, and reproducible. The aim of this study was to test the combined role of those techniques for the diagnosis of sarcopenia in a population of hospitalized older males and females. Methods: A total of 70 subjects were recruited, including 10 healthy adults and 60 hospitalized elderly patients with a good level of independence and cooperation, with and without sarcopenia. The rectus femoris cross-sectional area (CSA), thickness, echogenicity, and compressibility were measured with ultrasound echography. The phase angles (PhAs) and skeletal muscle mass were calculated by bioimpedence analysis. The muscle quality index (MQI) was calculated as the product of CSA and PhA. Results: Muscle compressibility was greater and PhA was lower in sarcopenic when compared with non-sarcopenic subjects. The threshold values for sarcopenia diagnosis in both sexes of CSA, of PhA, and of the MQI were identified. The obtained CSA values showed an AUC of 0.852 for women and 0.867 for men, PhA of 0.792 in women and 0.898 in men, while MQI was 0.900 for women and 0.969 for men. Conclusions: The newly calculated cut-off values of CSA, PhA, and MQI predicted the presence of sarcopenia with good sensitivity and specificity values. The use of the MQI proved to be more promising than the separate use of CSA and PhA in both male and female subjects.