bluuebunny/crossref_metadata_2025 huggingface dataset:
Time course of interlimb strength transfer after unilateral handgrip training
Authors: Barss Trevor S. , Klarner Taryn , Pearcey Gregory E. P. , Sun Yao , Zehr E. Paul
Published: September 2018

"Cross-education” is the increase in strength or functional performance of an untrained limb after unilateral training. A major limitation for clinical translation from unilateral injury includes knowledge on the minimum time for the emergence of crossed effects. Therefore, the primary purpose was to characterize the time course of bilateral strength changes during both “traditional” ( n = 11) and “daily” ( n = 8) unilateral handgrip training in neurologically intact participants. Traditional training included five sets of five maximal voluntary handgrip contractions 3 times/wk for 6 wk whereas daily training included the same number of sessions and contractions but over 18 consecutive days. Three pre- and one posttest session evaluated strength, muscle activation, and reflex excitability bilaterally. Time course information was assessed by recording handgrip force for every contraction in the trained limb and from a single contraction on every third training session in the untrained limb. Six weeks of traditional training increased handgrip strength in the trained limb after the 9th session whereas the untrained limb was stronger after the 12th session. This was accompanied by increased peak muscle activation and bilateral alterations in Hoffmann reflex excitability. Daily training revealed a similar number of sessions (15) were required to induce significant strength gains in the untrained limb (7.8% compared with 12.5%) in approximately half the duration of traditional training. Therefore, minimizing rest days may improve the efficiency of unilateral training when the trained limb is not the focus. Establishing a “dose” for the time course of adaptation to strength training is paramount for effective translation to rehabilitative interventions.

NEW & NOTEWORTHY Unilateral handgrip training using a “traditional” protocol (3 times/wk; 6 wk) increased strength bilaterally after 9 (trained arm) and 12 (untrained arm) sessions. “Daily” training (18 consecutive days) increased strength in the untrained limb in a similar number of training sessions, which was accomplished in approximately half the time. Within clinical populations when the focus is on the untrained limb, reducing rest days may optimize the recovery of strength.
Regulation of regional cerebral blood flow during graded reflex-mediated sympathetic activation via lower body negative pressure
Authors: Kaur Jasdeep , Vranish Jennifer R. , Barbosa Thales C. , Washio Takuro , Young Benjamin E. , Stephens Brandi Y. , Brothers R. Matthew , Ogoh Shigehiko , Fadel Paul J.
Published: September 2018

The role of the sympathetic nervous system in cerebral blood flow (CBF) regulation remains unclear. Previous studies have primarily measured middle cerebral artery blood velocity to assess CBF. Recently, there has been a transition toward measuring internal carotid artery (ICA) and vertebral artery (VA) blood flow using duplex Doppler ultrasound. Given that the VA supplies autonomic control centers in the brainstem, we hypothesized that graded sympathetic activation via lower body negative pressure (LBNP) would reduce ICA but not VA blood flow. ICA and VA blood flow were measured during two protocols: protocol 1, low-to-moderate LBNP (−10, −20, −30, and −40 Torr) and protocol 2, moderate-to-high LBNP (−30, −50, and −70 Torr). ICA and VA blood flow, diameter, and blood velocity were unaffected up to −40 LBNP. However, −50 and −70 LBNP evoked reductions in ICA and VA blood flow [e.g., −70 LBNP: percent change (%∆)VA-baseline = −27.6 ± 3.0] that were mediated by decreases in both diameter and velocity (e.g., −70 LBNP: %∆VA-baseline diameter = −7.5 ± 1.9 and %∆VA-baseline velocity = −13.6 ± 1.7), which were comparable between vessels. Since hyperventilation during −70 LBNP reduced end-tidal pressure of carbon dioxide ([Formula: see text]), this decrease in [Formula: see text] was matched via voluntary hyperventilation. Reductions in ICA and VA blood flow during hyperventilation alone were significantly smaller than during −70 LBNP and were primarily mediated by decreases in velocity (%∆VA-baseline velocity = −8.6 ± 2.4 and %∆VA-baseline diameter = −0.05 ± 0.56). These data demonstrate that both ICA and VA were unaffected by low-to-moderate sympathetic activation, whereas robust reflex-mediated sympathoexcitation caused similar magnitudes of vasoconstriction in both arteries. Thus, contrary to our hypothesis, the ICA was not preferentially vasoconstricted by sympathetic activation.

NEW & NOTEWORTHY Our study demonstrates that moderate-to-high reflex-mediated sympathetic activation with lower body negative pressure (LBNP) decreases internal carotid artery and vertebral artery blood flow via reductions in both vessel diameter and blood velocity. This vasoconstriction was primarily sympathetically mediated as voluntary hyperventilation alone, to isolate the effect of decreases in end-tidal pressure of carbon dioxide that occurred during LBNP, resulted in a significantly smaller vasoconstriction. In contrast to our hypothesis, these data indicate a lack of heterogeneity between the anterior and posterior cerebral circulations in response to sympathoexcitation.
Double-Tension Wire Management of Nonunion Patella with Severe Quadriceps Contracture
Authors: Bhimani Rohan , Singh Preeti , Bhimani Fardeen
Published: September 2018

Introduction. Nonunion patella with quadriceps contracture is an unusual orthopaedic finding. Very few cases have been recorded in the past with this complication. We present a case of a 40-year-old male with nonunion patella with quadriceps contracture secondary to trauma. Case Report. A 40-year-old male with posttraumatic nonunion patella with quadriceps contracture since 6 months presented with complaints of defect in the left knee with restriction of movements. X-ray of the left knee confirmed our findings. He underwent quadricepsplasty with double-tension band wiring for the patella followed by rigorous physiotherapy to achieve the current level of the knee flexion of 110 degrees. Conclusion. We conclude that quadricepsplasty with tension band wiring and neutralization wire is one of the good modalities of treatment for a nonunion patella associated with quadriceps contracture.
Adaptive 3D Distance‐Based Formation Control of Multiagent Systems with Unknown Leader Velocity and Coplanar Initial Positions
Authors: Lan Xuejing , Xu Wenbiao , Wei Yun-Shan
Published: September 2018

This paper considers the distributed 3‐dimensional (3D) distance‐based formation control of multiagent systems, where the agents are connected based on an acyclic minimally structural persistent (AMSP) graph. A parameter is designed according to the desired formation shape and is used to solve the problem that there are two formation shapes satisfying the same distance requirements. The unknown moving velocity of the leader agent is estimated adaptively by the followers requiring only the relative position measurements with respect to their local coordinate systems. In addition, the proposed formation controller provides a new way for the agent to leave the initial coplanar location. The 3D formation control law is globally asymptotically stable and has been demonstrated based on the Lyapunov theorem. Finally, two numerical simulations are presented to support the theoretical analysis.
Cardiovascular Risk Assessment in Angolan Adults: A Descriptive Analysis from CardioBengo, a Community-Based Survey
Authors: Pedro João M. , Brito Miguel , Barros Henrique
Published: September 2018

From a community-based survey conducted in Angola, 468 individuals aged 40 to 64 years and not using drug therapy were evaluated according to the World Health Organisation STEPwise Approach to Chronic Disease Risk Factor Surveillance. Using data from tobacco use, blood pressure, blood glucose, and total cholesterol levels, we estimated the 10-year risk of a fatal or nonfatal major cardiovascular event and computed the proportion of untreated participants eligible for pharmacological treatment according to clinical values alone and total cardiovascular risk. The large majority of participants were classified as having a low (<10%) 10-year cardiovascular risk (87.6%), with only 4.5% having a high (≥ 20%) cardiovascular risk. If we consider the single criteria for hypertension, 48.7% of the population should be considered for treatment. This value decreases to 22.0% if we apply the risk prediction chart. The use of hypoglycaemic drugs does not present any differences (19.0% in both situations). The use of lipid-lowering drugs (3.8%) is only recommended by the risk prediction chart. This study reveals the need of integrated approaches for the treatment of cardiovascular disorders in this population. Risk prediction charts can be used as a way to promote a better use of limited resources.
Ranking Analysis for Online Customer Reviews of Products Using Opinion Mining with Clustering
Authors: Lakshmanaprabu S. K. , Shankar K. , Gupta Deepak , Khanna Ashish , Rodrigues Joel J. P. C. , Pinheiro Plácido R. , de Albuquerque Victor Hugo C.
Published: September 2018

Sites for web‐based shopping are winding up increasingly famous these days. Organizations are anxious to think about their client purchasing conduct to build their item deal. Internet shopping is a method for powerful exchange among cash and merchandise which is finished by end clients without investing a huge energy spam. The goal of this paper is to dissect the high‐recommendation web‐based business sites with the help of a collection strategy and a swarm‐based improvement system. At first, the client surveys of the items from web‐based business locales with a few features were gathered and, afterward, a fuzzy c‐means (FCM) grouping strategy to group the features for a less demanding procedure was utilized. Also, the novelty of this work—the Dragonfly Algorithm (DA)—recognizes ideal features of the items in sites, and an advanced ideal feature‐based positioning procedure will be directed to discover, at long last, which web‐based business webpage is best and easy to understand. From the execution, the outcomes demonstrate the greatest exactness rate, that is, 94.56% compared with existing methods.
Carapa guianensis Aublet (Andiroba) Seed Oil: Chemical Composition and Antileishmanial Activity of Limonoid-Rich Fractions
Authors: Oliveira Iara dos Santos da Silva , Moragas Tellis Carla Junqueira , Chagas Maria do Socorro dos Santos , Behrens Maria Dutra , Calabrese Kátia da Silva , Abreu-Silva Ana Lucia , Almeida-Souza Fernando
Published: September 2018

Leishmaniasis is a complex of diseases caused by protozoa of the genus Leishmania and affects millions of people around the world. Several species of plants are used by traditional communities for the treatment of this disease, among which is Carapa guianensis Aubl. (Meliaceae), popularly known as andiroba. The objective of the present work was to conduct a chemical study of C. guianensis seed oil and its limonoid-rich fractions, with the aim of identifying its secondary metabolites, particularly the limonoids, in addition to investigating its anti-Leishmania potential. The chemical analyses of the C. guianensis seed oil and fractions were obtained by electrospray ionization mass spectrometry (ESI-MS). The cytotoxic activity was tested against peritoneal macrophages, and antileishmanial activity was evaluated against promastigotes and intracellular amastigotes of Leishmania amazonensis. All the C. guianensis seed oil samples analyzed exhibited the same pattern of fatty acids, while the limonoids 7-deacetoxy-7-hydroxygedunin, deacetyldihydrogedunin, deoxygedunin, andirobin, gedunin, 11β-hydroxygedunin, 17-glycolyldeoxygedunin, 6α-acetoxygedunin, and 6α,11β-diacetoxygedunin were identified in the limonoid-rich fractions of the oil. The C. guianensis seed oil did not exhibit antileishmanial activity, and cytotoxicity was higher than 1000 μg/mL. Three limonoid-rich oil fractions demonstrated activity against promastigotes (IC50 of 10.53±0.050, 25.3±0.057, and 56.9±0.043μg/mL) and intracellular amastigotes (IC50 of 27.31±0.091, 78.42±0.086, and 352.2±0.145 μg/mL) of L. amazonensis, as well as cytotoxicity against peritoneal macrophages (CC50 of 78.55±1.406, 139.0±1.523, and 607.7±1.217 μg/mL). The anti-Leishmania activity of the limonoid-rich fractions of C. guianensis can be attributed to the limonoids 11β-hydroxygedunin and 6α,11β-diacetoxygedunin detected in the chemical analysis.
Prevalence of Keratoconus in a Refractive Surgery Population
Authors: Al-Amri Abdulrahman Mohammed
Published: September 2018

Objective. This study examined the prevalence of keratoconus among patients who were interested in undergoing refractive surgery. Corneal tomography measurements were used to help detect keratoconus.Methods. Adult subjects who presented to the private hospital Cataract and Refractive Surgery Unit (Abha, Saudi Arabia) for refractive surgery evaluation were considered for inclusion in this cross-sectional, retrospective study. All subjects were from the Aseer province, a southern, high-altitude region in Saudi Arabia, and presented between January and December 2017. The incidence of keratoconus and other refractive surgery contraindications were examined.Results. A total of 2931 patients were considered for inclusion in analyses. Of these, 2280 patients (77.8%) were not candidates for refractive surgery. These 2280 patients had a mean age of 24.1 ± 6.6 years and 1231 patients (54.0%) were male. Of the subjects who did not undergo refractive surgery, 548 (24%) had keratoconus, 400 (17.5%) were keratoconus suspects, 344 (15.1%) had thin corneas, 321 (14.1%) had high myopia, and 52 (2.3%) had a high astigmatism. An additional 479 subjects (21%) were candidates for refractive surgery, but chose not to undergo a procedure.Conclusion. The incidence of keratoconus in Saudi Arabian refractive surgery prospects was 18.7%. Keratoconus was the most common reason for not performing refractive surgery and accounted for 24.0% of cases in which surgery was not performed.
Machine Learning for Estimating Leaf Dust Retention Based on Hyperspectral Measurements
Authors: Jing Wenlong , Zhou Xia , Zhang Chen , Wang Chongyang , Jiang Hao
Published: September 2018

Hyperspectral sensors provide detailed information for dust retention content (DRC) estimation. However, rich hyperspectral data are not fully utilized by traditional image analysis techniques. We integrated several recently developed machine learning algorithms to estimate DRC on plant leaves using the spectra measured by the ASD FieldSpec 3. The experiments were carried out on three common green plants of southern China. The important hyperspectral variables were first identified by applying the random forest (RF) algorithm. Three estimation models were then developed using the support vector machine (SVM), classification and regression tree (CART), and RF algorithms. The results showed that the increase in dust retention contents on plant leaves enhanced their reflectance in the visible wavelength but weakened their reflectance in the infrared wavelength. Wavelengths in the ranges of 450–500 nm, 550–600 nm, 750–1000 nm, and 1100–1300 nm were identified as important variables using the RF algorithm and were used to estimate the DRC. The comparison of the three machine learning techniques for DRC estimation confirmed that the SVM and RF models performed well because their estimations were similar to the measured DRC. Specifically, the average R2 for SVM and RF model are 0.85 and 0.88. The technical approach of this study proved to be a successful illustration of using hyperspectral measurements to estimate the DRC on plant leaves. The findings of this study can be applied to monitor the DRC on leaves of other plants and can also be integrated with other types of spectral data to measure the DRC at a regional scale.
Determinants of Nursing Process Implementation in North East Ethiopia: Cross-Sectional Study
Authors: Miskir Yihun , Emishaw Solomon
Published: September 2018

Nursing process is a framework used to provide an effective, coordinated, and organized quality care for patients. Effective implementation of this framework leads to improved quality of care and decreases potential complication, hospital length of stay, and the cost of care. To assess implementation of nursing process and its hindering factors, a quantitative cross-sectional study was conducted among nurses in Afar region hospitals from October 2016 to December 2016. The data were collected from 102 nurses using primary Brooking’s ward nurses’ self-report questionnaire and with some newly prepared questions. The collected data were entered using Epi-Data version 3.1 and analyzed by SPSS version 20 and then presented by tables, graphs, and figures. Forty-three (42.1%) nurses were implementing nursing process at the time of data collection. Assessment and diagnosis were carried out by 57 (56.9%) nurses, planning by 46% of nurses, implementation by 38.2% of nurses, and evaluation by 36.2% of nurses in Afar region. Among the hindering factors towards nursing process implementation, lack of preparedness or knowledge about the nursing process or some part of it (83.3%) and absence of in-service training pertinent to nursing process (75.5%) were the most mentioned ones. Generally, nursing process was poorly implemented in Afar region mainly due to lack of knowledge and absence of in service training. Therefore, giving emphasis for cognitive parts of students about nursing process during their school time and refreshing nurse staffs with continuous training will definitively improve level of nursing process implementation.
Effect of Precooking and Superheated Steam Treatment on Quality of Black Glutinous Rice
Authors: Piyawanitpong Chinnatat , Therdthai Nantawan , Ratphitagsanti Wannasawat
Published: September 2018

Consumption of glutinous rice has been increasing. Leum Pua rice (Oryza sativa Linn.) is black glutinous rice containing high nutrition, but its cooking process is time-consuming. This study aimed at decreasing cooking time by changing rice properties using superheated steam treatment. The black glutinous rice was subjected to pretreatment: uncooking and precooking before superheated steam treatment at 250°C and 300°C. Drying rate constant (k) of uncooked rice was 0.0301–0.0744 s−1. Precooking rice prior to superheated steam treatment at 300°C reduced the kinetic rate constant to 0.0596 s−1. From SEM, porosity of the treated rice was observed. However, superheated steam treatment reduced ferric reducing antioxidant power and total phenolic content, compared with control. From X-ray diffraction, A-type crystalline structure of the treated rice was disappeared. Cooking time of the superheated steam-treated rice was reduced to 1–5 min. Their hardness and overall liking scores were comparable to control.
The Influence of Incident Power on the Magnetic Fluid Sensor Sensitivity Based on Optical Transmission Properties
Authors: Li Yongqian , Zhang Hao , Yang Zhi , Yuan Baoyi , Yuan Ze , Xue Hailong
Published: September 2018

Sensitivity is a critical characteristic of sensors, and increasing the sensitivity of the sensor is valuable for measurement study. Incident power has an important influence on the sensitivity of magnetic fluid sensors based on optical transmission properties. Variation in the magnetic field sensitivity at different incident powers was investigated by the measurement of transmitted power through the magnetic fluid sensors. As the magnetic field strength increases, the sensitivity variation of the magnetic fluid film sensor can be divided into four stages: first decreasing sharply, secondly increasing, then decreasing gradually, and finally tending toward a small stable value. The magnitudes of the change in the sensor sensitivity are influenced by the incident power, because the structural pattern of the nano-magnetic particles in the magnetic fluid sensor changes, the Soret effect and the Photonic Hall effect co-define the sensing system. In the weak magnetic field range, when a higher sensitivity is required, it is appropriate to select a larger incident power; however, in a large magnetic field range, when a higher sensitivity is required, a small incident power should be selected. Therefore, the magnetic fluid film sensor exhibits different sensitivity characteristics if different incident power values are chosen. The appropriate incident power can be selected according to the range of the magnetic field to be measured to improve the sensitivity in the magnetic field measurement study.
Detecting and Isolating Black‐Hole Attacks in MANET Using Timer Based Baited Technique
Authors: Yasin Adwan , Abu Zant Mahmoud
Published: September 2018

Mobile Ad hoc Network (MANET) is a type of wireless networks that provides numerous applications in different areas. Security of MANET had become one of the hottest topics in networks fields. MANET is vulnerable to different types of attacks that affect its functionality and connectivity. The black‐hole attack is considered one of the most widespread active attacks that degrade the performance and reliability of the network as a result of dropping all incoming packets by the malicious node. Black‐hole node aims to fool every node in the network that wants to communicate with another node by pretending that it always has the best path to the destination node. AODV is a reactive routing protocol that has no techniques to detect and neutralize the black‐hole node in the network. In this research, we enhanced AODV by integrating a new lightweight technique that uses timers and baiting in order to detect and isolate single and cooperative black‐hole attacks. During the dynamic topology changing the suggested technique enables the MANET nodes to detect and isolate the black‐hole nodes in the network. The implementation of the proposed technique is performed by using NS‐2.35 simulation tools. The results of the suggested technique in terms of Throughput, End‐to‐End Delay, and Packet Delivery Ratio are very close to the native AODV without black holes.
Clinical Pharmacology of Tisagenlecleucel in B-cell Acute Lymphoblastic Leukemia
Authors: Mueller Karen Thudium , Waldron Edward , Grupp Stephan A. , Levine John E. , Laetsch Theodore W. , Pulsipher Michael A. , Boyer Michael W. , August Keith J. , Hamilton Jason , Awasthi Rakesh , Stein Andrew M. , Sickert Denise , Chakraborty Abhijit , Levine Bruce L. , June Carl H. , Tomassian Lori , Shah Sweta S. , Leung Mimi , Taran Tetiana , Wood Patricia A. , Maude Shannon L.
Published: September 2018

Purpose:

Tisagenlecleucel is an anti-CD19 chimeric antigen receptor (CAR19) T-cell therapy approved for the treatment of children and young adults with relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (B-ALL).

Patients and Methods:

We evaluated the cellular kinetics of tisagenlecleucel, the effect of patient factors, humoral immunogenicity, and manufacturing attributes on its kinetics, and exposure-response analysis for efficacy, safety and pharmacodynamic endpoints in 79 patients across two studies in pediatric B-ALL (ELIANA and ENSIGN).

Results:

Using quantitative polymerase chain reaction to quantify levels of tisagenlecleucel transgene, responders (N = 62) had ≈2-fold higher tisagenlecleucel expansion in peripheral blood than nonresponders (N = 8; 74% and 104% higher geometric mean Cmax and AUC0-28d, respectively) with persistence measurable beyond 2 years in responding patients. Cmax increased with occurrence and severity of cytokine release syndrome (CRS). Tisagenlecleucel continued to expand and persist following tocilizumab, used to manage CRS. Patients with B-cell recovery within 6 months had earlier loss of the transgene compared with patients with sustained clinical response. Clinical responses were seen across the entire dose range evaluated (patients ≤50 kg: 0.2 to 5.0 × 106/kg; patients >50 kg: 0.1 to 2.5 × 108 CAR-positive viable T cells) with no relationship between dose and safety. Neither preexisting nor treatment-induced antimurine CAR19 antibodies affected the persistence or clinical response.

Conclusions:

Response to tisagenlecleucel was associated with increased expansion across a wide dose range. These results highlight the importance of cellular kinetics in understanding determinants of response to chimeric antigen receptor T-cell therapy.
Exosomal miR-27a Derived from Gastric Cancer Cells Regulates the Transformation of Fibroblasts into Cancer-Associated Fibroblasts
Authors: Wang Jingya , Guan Xuwen , Zhang Yue , Ge Shaohua , Zhang Le , Li Hongli , Wang Xia , Liu Rui , Ning Tao , Deng Ting , Zhang Haiyang , Jiang Xiangli , Ba Yi , Huang Dingzhi
Published: September 2018

Background/Aims: The malignant biological behavior of gastric cancer(GC) is not only determined by cancer cells alone, but also closely regulated by the microenvironment. Fibroblasts represent a large proportion of the components in the tumor microenvironment, and they promote the development of disease. Currently, accumulating evidence suggests that exosomes can function as intercellular transport systems to relay their contents, especially microRNAs(miRNAs). Methods: First, we detected the highly-expressed level of miR-27a in exosomes isolated from gastric cancer cells by qRT-PCR. MiR-27a –over-expressed models in vitro and in vivo were established to investigate the transformation of cancer-associated fibroblasts observed by Western blotting, and the malignant behavior of gastric cancer cells using the methods CCK8 and Transwell. Moreover, the downregulation of CSRP2 in fibroblasts was used to evaluate the promotion of malignancy of gastric cancer using the methods CCK8 and Transwell. Results: In this study, we found a marked high level of miR-27a in exosomes derived from GC cells. miR-27a was found to function an oncogene that not only induced the reprogramming of fibroblasts into cancer-associated fibroblasts(CAFs), but also promoted the proliferation, motility and metastasis of cancer cells in vitro and in vivo. Conversely, CAFs with over-expression of miR-27a could pleiotropically increase the malignant behavior of the GC cells. For the first time, we revealed that CSRP2 is a downstream target of miR-27a. CSRP2 downregulation could increase the proliferation and motility of GC cells. Conclusion: Thus, this report indicates that miR-27a in exosomes derived from GC cells has a crucial impact on the microenvironment and may be used as a potential therapeutic target in the treatment of GC
Spatial Frequency Tolerant Visual Object Representations in the Human Ventral and Dorsal Visual Processing Pathways
Authors: Vaziri-Pashkam Maryam , Taylor JohnMark , Xu Yaoda
Published: September 2018

Primate ventral and dorsal visual pathways both contain visual object representations. Dorsal regions receive more input from magnocellular system while ventral regions receive inputs from both magnocellular and parvocellular systems. Due to potential differences in the spatial sensitivites of manocellular and parvocellular systems, object representations in ventral and dorsal regions may differ in how they represent visual input from different spatial scales. To test this prediction, we asked observers to view blocks of images from six object categories, shown in full spectrum, high spatial frequency (SF), or low SF. We found robust object category decoding in all SF conditions as well as SF decoding in nearly all the early visual, ventral, and dorsal regions examined. Cross-SF decoding further revealed that object category representations in all regions exhibited substantial tolerance across the SF components. No difference between ventral and dorsal regions was found in their preference for the different SF components. Further comparisons revealed that, whereas differences in the SF component separated object category representations in early visual areas, such a separation was much smaller in downstream ventral and dorsal regions. In those regions, variations among the object categories played a more significant role in shaping the visual representational structures. Our findings show that ventral and dorsal regions are similar in how they represent visual input from different spatial scales and argue against a dissociation of these regions based on differential sensitivity to different SFs.
Heirs Apparent in Juxtaposition: David in Samuel-Kings and Michael Corleone in The Godfather
Authors: Aichele George , Miscall Peter D. , Walsh Richard
Published: September 2018

We read together the story of David in 1 Samuel 16-2 Kings 2 and that of Michael Corleone in The Godfather. They both begin outside the main power structure, the kingdom of Saul and the crime family, and then rise, often through the use of violence, to the top: King and Don. David’s decisive slaying of Goliath is matched by Michael’s assassination of Sollozzo and McCluskey. After the killings both are now recognized as serious “players” in their respective structures. As they move up the power chain David and Michael, as characters in biblical narrative and modern film, are haunted by the possibility that their stories could have been different: the innocent young shepherd and the decorated Marine. Both could be separate from the violence and corruption of Israelite monarchy and of the Corleone family.
XML Annotation of Hebrew Elements in Judeo-Arabic Texts
Authors: Ahmed Mohamed A. H.
Published: September 2018

The main aim of this study is to introduce a model ofTEI(Text Encoding Initiative) annotation of Hebrew elements in Judeo-Arabic texts, i.e., code switching (CS), borrowing, and Hebrew quotations. This article will provide an introduction to using XML (Extensible Markup Language) to investigate sociolinguistic aspects in medieval Judeo-Arabic texts. Accordingly, it will suggest to what extent using XML is useful for investigating linguistic and sociolinguistic features in the Judeo-Arabic paradigm. To provide an example for how XML annotation could be applied to Judeo-Arabic texts, a corpus of 300 pages selected from three Judeo-Arabic books has been manually annotated using theTEIP5. The annotation covers all instances ofCS, borrowing, and Hebrew quotations in that corpus.
Lanlabeo duanensis, a new genus and species of labeonin fish (Teleostei: Cyprinidae) from southern China
Authors: YAO MIN , HE YOU , PENG ZUO-GANG
Published: September 2018

Lanlabeo, a new genus of fish belonging to the family Cyprinidae, is described from the Pearl River drainage basin in Guangxi Province, southern China. This new genus is distinguished from all other genera of the cyprinid tribe Labeonini by a combination of morphological and phylogenetic characters. It differs morphologically from all other Asian labeonins in its uniquely modified oromandibular morphology. For example, this genus has a frenum connecting the upper jaw and lower lip at the corner of the mouth, regularly arranged papillae densely scattered over the ventral margin of the rostral cap, a vestigial upper lip, a rostral cap overlying the upper jaw and with a fimbriate posterior margin, and a lower lip divided into two lateral fleshy lobes and one central plate. These two lateral fleshy lobes are small and translucent, and the median lobe of the lower lip is large and has papillae regularly arranged in many transverse rows. In the lower jaw, the dentary is transversely L-shaped in ventral view because its anterior part forms a right-angle turn and its transverse branch is anterioposteriorly expanded. In addition, analyses of four nuclear gene datasets indicate that this new genus forms a highly divergent lineage within the Labeonini, and that Lanlabeo is closely related to the genus Ptychidio. Therefore, based on morphometric differences and phylogenetic relationships, we describe this new genus herein as Lanlabeo, containing the new species Lanlabeo duanensis.
First Iranian record of the family Odiniidae (Diptera: Opomyzoidea), including two species new to the Middle East region
Authors: PARCHAMI-ARAGHI MEHRDAD , MAJNON-JAHROMI BAHAREH , GILASIAN EBRAHIM , WITHERS PHILIP , GAIMARI STEPHEN D. , FALLAHZADEH MAJID
Published: September 2018

The family Odiniidae is newly reported from Iran through the recent discovery of the species Odinia meijerei Collin, 1952 and Turanodinia graciosa Krivosheina & Krivosheina, 1996 in Iran and the Middle East region. The species T. graciosa is here elevated from the rank of subspecies (Turanodinia stackelbergi graciosa Krivosheina & Krivosheina, 1996) to species level. This taxonomical change was based on the comparison of the male genitalia of T. graciosa with T. stackelbergi Krivosheina & Krivosheina. Images of the habitus and male genitalia of O. meijerei and T. graciosa are provided.
ANZUS and the Early Cold War
Authors: Kelly Andrew
Published: September 2018

Upon the conclusion of the ANZUS Treaty, four key issues caused considerable discord or uncertainty between the signatories: the ANZUS machinery, whether Britain would become a member or observer of council meetings, establishing a five-power staff agency in Southeast Asia, and the inauguration of President Eisenhower in January 1953. This chapter explores these developments and emphasises how the conclusion of the treaty did little to encourage immediate agreement on mutual security issues.
ANZUS and the Early Cold War
Authors: Kelly Andrew
Published: September 2018

This book ends by summarising the main themes that surfaced throughout this period, such as the impact of US leadership on ANZUS and the British role in causing policy disagreements between the signatories. It also outlines how these issues set the foundations for future policy issues, such as trans-Tasman participation in the Vietnam War despite British non-participation, New Zealand withdrawal from ANZUS in the mid-1980s, and Australia invoking ANZUS for the first time in the wake of the September 11 terrorist attacks. In short, the conclusion demonstrates how this study provides a solid framework for understanding the early motives and issues that shaped the trilateral relationship for the remainder of the 20th century and beyond.
Prediction of the Onset of Heavy Rain Using SEVIRI Cloud Observations
Authors: Patou Maximilien , Vidot Jérôme , Riédi Jérôme , Penide Guillaume , Garrett Timothy J.
Published: September 2018

Thunderstorms and strong precipitation events can be highly variable in space and time and therefore are challenging to forecast. Geostationary satellites are particularly well suited for studying their occurrence and development. This paper describes a methodology for tracking temporal trends in the development of these systems using a combination of a ground-based radar rainfall product and cloud fields derived from the Meteosat Second Generation’s (MSG) Spinning Enhanced Visible and Infrared Imager (SEVIRI). Cloud microphysical and radiative properties and the cloud perimeter-to-area ratio are used to characterize the temporal evolution of 35 cases of isolated convective development. For synchronizing temporal trends between cases, two reference times are used: the time when precipitating clouds reach a rain intensity threshold and the time of the maximum of rain intensity during the cloud life cycle. A period of decreasing cloud perimeter-to-area ratio before heavy rainfall is observed for both synchronization techniques, suggesting this parameter could be a predictor of heavy rain occurrence. However, the choice of synchronization time does impact significantly the observed trend of cloud properties. An illustration of how this approach can be applied to cloud-resolving models is presented to evaluate their ability to simulate cloud processes.
Shaping activation policy at the street level: Governing inactivity in youth employment services
Authors: Haikkola Lotta
Published: September 2018

Activation policies form the core of employment policies in most OECD countries. They are part of ‘active’ welfare states and associated neoliberal forms of governance that seek to govern through freedom by producing self-governing and responsible subjectivities. Ethnographies of governmentalities have been used in the research reported in this article to examine if and how such subjectivities are put in practice in street-level encounters in local welfare delivery. Based on an ethnographic research of youth services in the Public Employment Services (PES) in Helsinki, Finland, it is shown that despite the policy focus on active citizenship the street-level practice entails not only liberal ideas of self-governing individuals but also authoritarian measures. What is governed in the meetings is not the young people’s selves but their time and behaviour. In the process, the notion of active citizenship is emptied and transformed to mean participation in supervised activities offered by the PES. Such practice also reworks the temporal structures and creates insecure and eventful experience of time for PES clients. In contrast to governing through freedom, the localized interpretation of activation policies represents the authoritarian and paternalistic side of neoliberal governance.
The Study of Laryngoscopic and Autonomic Patterns in Exercise-Induced Laryngeal Obstruction
Authors: Shembel Adrianna C. , Hartnick Christopher J. , Bunting Glenn , Ballif Catherine , Vanswearingen Jessie , Shaiman Susan , Johnson Aaron , de Guzman Vanessa , Verdolini Abbott Katherine
Published: September 2018

Objectives:

(1) Identify laryngeal patterns axiomatic to exercise-induced laryngeal obstruction (EILO) and (2) investigate the role of autonomic function in EILO.

Methods:

Twenty-seven athletic adolescents (13 EILO, 14 control) underwent laryngoscopy at rest and exercise. Glottal configurations, supraglottic dynamics, systolic blood pressure responses, and heart rate recovery were compared between conditions and groups.

Results:

Inspiratory glottal angles were smaller in the EILO group than the control group with exercise. However, group differences were not statistically significant ( P > .05), likely due to high variability of laryngeal responses in the EILO group. Expiratory glottal patterns showed statistically greater abductory responses to exercise in the control group ( P = .001) but not the EILO group ( P > .05). Arytenoid prolapse occurred variably in both groups. Systolic blood pressure responses to exercise were higher in the control group, and heart rate recovery was faster in the EILO group. However, no significant differences were seen between the 2 groups on either autonomic parameter ( P > .05).

Conclusions:

“Paradoxical” inspiratory and blunted expiratory vocal fold pattern responses to exercise best characterize EILO. Group differences were only seen with exercise challenge, thus highlighting the utility of provocation and control groups to identify EILO.
Study on Normal Laryngeal Electromyography of Thyroarytenoid Muscle, Cricothyroid Muscle, and Posterior Cricoarytenoid Muscle
Authors: Xu Xinlin , Yang Pan , Zhuang Peiyun , Yanchao Jiao , Yanli Ma , Schrof Colin , Jiang Jack J.
Published: September 2018

Objective:

The aim of this study was to investigate the physiological activity of intrinsic laryngeal muscle under different functional states of larynx by measuring the normal laryngeal electromyography parameters.

Methods:

Laryngeal electromyography (EMG) was performed in 112 patients with unilateral vocal cord movement disorder. The duration and amplitude of the motor unit potential (MUP) of the thyroarytenoid muscle (TA), posterior cricoarytenoid muscle (PCA), and cricothyroid muscle (CT) were measured when patients were asked to make a deep inspiration and phonate /i/. The normal side of the patients’ vocal chords was used as the research object.

Results:

(1) The motor unit potential of TA, CT, and PCA were measured when inspiration and phonating /i/. Waveforms were normal. (2) There were significant differences in duration of TA between inspiration and phonating /i/ in comfortable tone. (3) When comparing the duration and amplitude of any 2 of TA, CT, and PCA during inspiration and phonating /i/, there were significant differences in duration between CT and PCA when phonating /i/ only. There were no significant differences in any other comparisons.

Conclusions:

Under either deep inspiration or pronunciation, the TA, CT, and PCA muscles were activated. The TA may play a major role in phonating. The PCA may play a major role in the action of deep inspiration.
Mobile Applications for Allergic Rhinitis
Authors: Zhou Albert H. , Patel Varesh R. , Baredes Soly , Eloy Jean Anderson , Hsueh Wayne D.
Published: September 2018

Objective:

To study and review the currently available mobile applications relating to allergic rhinitis.

Methods:

The Apple and Google mobile app stores were queried with search terms relating to allergic rhinitis. Apps were assigned to categories and analyzed based on description and characteristics such as popularity, reviews, cost, platform, and physician involvement in development.

Results:

A total of 72 apps related to allergic rhinitis were identified. Fifty-four apps were unique, with 18 apps found on both operating systems. Forty (55.5%) apps were available in the Apple App store, and 32 (44.4%) apps were available in the Google Play app store. They were grouped into the following categories: patient education (18; 25%), journals (15; 20.8%), symptom tracking (14; 19.4%), clinical/private practice (13; 18.1%), pollen forecast (7; 9.7%), medical education (4; 5.6%), and other (1; 1.4%). The majority of apps were free of charge (67; 93.1%), with paid apps ranging from $1.47 to $4.99. Apps that were reviewed had an average rating of 3.9 out of 5. Physicians were involved in the development of 37 (51.4%) apps.

Conclusions:

The collection of mobile apps developed for allergic rhinitis includes those for both educational and clinical use. Mobile apps may have an increasing role in otolaryngic allergy and rhinology practices in the future. Thus, continued research is warranted to determine the best way to ensure the accuracy and quality of app content as well as the extent mobile apps can benefit allergic rhinitis patients.
Nebulized Normal Saline Solution for Treatment of Bronchial Asthma Exacerbations and Bronchiolitis: Not Standard of Care
Authors: Hassan Shadwa , Gonzalez Anthony , Demissie Seleshi , Morawakkoralage Kashun , James Pushpom
Published: September 2018

Nebulized normal saline is frequently prescribed for the treatment of bronchiolitis or bronchial asthma exacerbations. We aimed to reinforce guidelines care by educating providers on the futility of saline administration. Frequency and indications for nebulized normal saline prescription were documented from November 1, 2014, to April 1, 2015, and then again, after dissemination of educational material to providers, from November 1, 2016, to April 1, 2017. A total of 263 patients had bronchiolitis and 470 had asthma. Nebulized normal saline for bronchiolitis decreased significantly in the emergency department (ED) and inpatient settings ( P < .001 and P = .027, respectively). For asthma exacerbations, the use of nebulized normal saline decreased significantly in the inpatient setting ( P = .025), while in the ED, numbers were low at baseline and remained unchanged. Nebulized normal saline administration in the hospital setting results in continued use in the community, where this leads to unnecessary ED visits, where first-line therapy should have been administered.
The Power of Institutionalized Disciplinarity: Molefi Asante’s Visionary and Pioneering Contributions to African American Studies
Authors: Mazama Ama
Published: September 2018

As Temple University’s Department of Africology celebrates the 30th anniversary of its doctoral program, the first of its kind, it is necessary to examine closely the vision and actions of the person, Molefi Kete Asante, who brought this doctoral program into existence. This close examination reveals that Asante’s contributions to African American Studies have been both substantial and institutional, and by all accounts, quite significant. Although occurring simultaneously, these substantial and institutional contributions will be presented separately for the sake of conceptual clarity.
Biological and Mechanical Evaluation of Novel Prototype Dental Composites
Authors: Van der Laan H.L. , Zajdowicz S.L. , Kuroda K. , Bielajew B.J. , Davidson T.A. , Gardinier J. , Kohn D.H. , Chahal S. , Chang S. , Liu J. , Gerszberg J. , Scott T.F. , Clarkson B.H.
Published: September 2018

The breakdown of the polymeric component of contemporary composite dental restorative materials compromises their longevity, while leachable compounds from these materials have cellular consequences. Thus, a new generation of composite materials needed to be designed to have a longer service life and ensure that any leachable compounds are not harmful to appropriate cell lines. To accomplish this, we have developed concurrent thiol-ene-based polymerization and allyl sulfide–based addition-fragmentation chain transfer chemistries to afford cross-linked polymeric resins that demonstrate low shrinkage and low shrinkage stress. In the past, the filler used in dental composites mainly consisted of glass, which is biologically inert. In several of our prototype composites, we introduced fluorapatite (FA) crystals, which resemble enamel crystals and are bioactive. These novel prototype composites were benchmarked against similarly filled methacrylate-based bisphenol A diglycidyl ether dimethacrylate / triethylene glycol dimethacrylate (bisGMA/TEGDMA) composite for their cytotoxicity, mechanical properties, biofilm formation, and fluoride release. The leachables at pH 7 from all the composites were nontoxic to dental pulp stem cells. There was a trend toward an increase in total toughness of the glass-only-filled prototype composites as compared with the similarly filled bisGMA/TEGDMA composite. Other mechanical properties of the glass-only-filled prototype composites were comparable to the similarly filled bisGMA/TEGDMA composite. Incorporation of the FA reduced the mechanical properties of the prototype and bisGMA/TEGDMA composite. Biofilm mass and colony-forming units per milliliter were reduced on the glass-only-filled prototype composites as compared with the glass-only-filled bisGMA/TEGDMA composite and were significantly reduced by the addition of FA to all composites. Fluoride release at pH 7 was greatest after 24 h for the bisGMA/TEGDMA glass + FA composite as compared with the similarly filled prototypes, but overall the F- release was marginal and not at a concentration to affect bacterial metabolism.
Including chiefs, maintaining peace? Examining the effects of state–traditional governance interaction on civil peace in sub-Saharan Africa
Authors: Mustasilta Katariina
Published: September 2018

The continued influence of traditional governance in sub-Saharan Africa has sparked increasing attention among scholars exploring the role of non-state and quasi-state forms of governance in the modern state. However, little attention has been given to cross-country and over-time variation in the interaction between state and traditional governance structures, particularly in regard to its implications for intrastate peace. This study examines the conditions under which traditional governance contributes to state capacity to maintain peace. The article argues that the type of institutional interaction between the state and traditional authority structures influences a country’s overall governance dynamics and its capacity to maintain peace. By combining new data on state–traditional authorities’ interaction in sub-Saharan Africa from 1989 to 2012 with intrastate armed conflict data, I conduct a systematic comparative analysis of whether concordant state–traditional authorities’ interaction strengthens peace. The empirical results support the argument that integrating traditional authorities into the public administration lowers the risk of armed conflict in comparison to when they remain unrecognized by the state. Moreover, the analysis suggests that the added value of this type of interaction is conditional on the colonial history of a country.