bluuebunny/crossref_metadata_2025 huggingface dataset:
Uso do ozônio no tratamento de feridas: revisão de escopo
Authors: Carneiro Cordeiro Nobre Vera Patricia , Gehring Junior Waldemar , Antar Gamba Mônica , Santos de Souza Oliveira Lavinia , Taminato Mônica
Published: May 2022

Objetivo: identificar evidências sobre o uso do ozônio no tratamento tópico de feridas cutâneas em humanos. Método: revisão de escopo, realizada em março de 2021 nas bases de dados Cochrane Library, Literatura Latino-Americana e do Caribe em Ciências da Saúde, Scientific Eletronic Library Online e National Library of Medicine com os descritores em Ciências da Saúde nas combinações: Cicatrização, Ozônio, Feridas e Lesões. Foram selecionados 1352 artigos, elegí­veis 129 e analisados em detalhe 09. Resultados: os estudos mostraram que o ozônio é uma terapia vantajosa na estimulação cicatricial das feridas cutâneas devido í s suas diversas potencialidades. Conclusão: há evidências da efetividade do uso do ozônio no tratamento de feridas, principalmente nas formas de gás e óleos, sendo necessários novos estudos a fim de parametrizar sua aplicação e os indicadores de cicatrização.
An IoT based Automated and Intelligent System for Patient Health
Authors: Nivedita S. , Kala R.
Published: May 2022

The Internet of Things (IoT) has remained extensively to connect accessible medical resources and provide smooth, dependable, and in effect of healthcare services to patients, and it has the potential to disrupt healthcare innovation. Health monitoring system using IoT application is the recent trend in medical field, by discovering the potential of the technology. Humans are incrassating the several issues and precocious death due to numerous illness, and by deficiency in providing medical treatment to the patients. To obtain the solution to this issue, a real time health monitoring system is proposed based on the recent technology such as IoT. Enhanced and intelligent healthcare system is the representation of developed and prosperous nation. The proposed method improves the monitoring system by shrinking the use of sensors, which have been attempted to exploit the new technology to obtain the solution for the healthcare problem currently society is facing, and a remote healthcare system is designed. The proposed automated and intelligent system involved with the different phases such as revealing the vitality of patient’s using sensors, sends patients data to cloud storage and thus providing it to the doctors to utilize it, which will help to access and observe the patient’s well-being improvement away from hospital locations. The proposed automated and intelligent system is used to interconnect the accessible medical resources and offer smart, reliable, and effective healthcare system to the people. An IoT architecture with customized healthcare applications have been developed to support remote health monitoring system.
INFÂNCIA EM TEMPOS DE PANDEMIA: ESCUTA, DESAFIOS E POSSIBILIDADES NO CENTRO DE EDUCAÇÃO INFANTIL PASTOR BILLY GRAHAM EM CAMPINAS, SÃO PAULO, BRASIL
Authors: Queiroz Thelma Yara Falca dos Reis , Ramos Aziz Júlio Salles , Yada Maria Lúcia Garcia
Published: May 2022

O cenário de pandemia gerado pela Covid-19 trouxe inúmeras preocupações e acentuou outras já existentes para aqueles que se interessam pela educação infantil. Dentre estas, estão o acesso das crianças às tecnologias digitais no contexto das instituições educacionais e/ou fora dele. O objetivo principal deste estudo foi mostrar os desafios e as possibilidades do processo ensino aprendizagem na primeira etapa da educação básica, realizadas durante a pandemia da Covid-19 no Centro de Educação Infantil Bem Querer Pastor Billy Graham em Campinas-SP. O método de pesquisa utilizado foi quali-quantitativo. Concluiu-se que as tecnologias foram recursos pedagógicos fundamentais para o processo ensino aprendizagem e para a manutenção de vínculo no momento pandêmico e que muitos desafios foram superados tantos pela equipe de profissionais da unidade educacional quanto para as famílias e crianças.
Bioprospecting of strawberry guava leaf essential oil in Caxias do Sul region, South Brazil
Authors: Silvestre Wendel Paulo , Mazzotti Luanna , Fernandes Pauletti Gabriel
Published: May 2022

The strawberry guava (Psidium cattleianum Sabine) is a fruit species native from South-Southeast Brazil whose leaf essential oil has potential for commercial uses due to its bioactive properties. However, little is known about the influence of the geographical distribution in small scale on P. cattleianum essential oil chemical composition and yield. The present work aimed to evaluate the yield and chemical composition of the leaf essential oil of P. cattleianum populations in the region of Caxias do Sul, South Brazil. Samples of twelve populations were collected and the essential oil was extracted by hydrodistillation. The chemical composition of the essential oils was determined by GC/MS and GC-FID. The results showed a high variability of essential oil yield, which ranged between 0.08 and 0.75% v/w. Regarding the chemical profiles, nine populations presented the 1,8-cineole chemotype, the β-caryophyllene chemotype was observed in two of them, and in one population there were four major compounds. Both hierarchical cluster and principal component analyses showed differences in essential oil composition in populations geographically close, indicating the existence of an important genetic variability in populations of the same geographical area.
Skapandet av tillit i en riskkontext. Om social riskacceptans vid lokalisering av anläggningar för radioaktivt och miljöfarligt avfall
Authors: Lidskog Rolf
Published: May 2022

Skapandet av tillit i en riskkontext. Om social riskacceptans vid lokalisering av anläggningar för radioaktivt och miljöfarligt avfallTaking Beck’s and Giddens’ recent formulation of the society’s new conditions for gaining trust as theoretical point of departure, this article focusses trust and risk with regard to hazardous and radioactive waste disposal in Sweden. Seeing trust as intimately connected with cognitive understanding of risks, the information strategies of the companies with responsibility for hazardous and radioactive waste management are analysed. Central in gaining trust is the creation of access points - points of connection between lay individuals or collectivities and the representatives of expert systems - at which trust can be built up or maintained. This article emphasizes that this kind of locational conflict is to be seen as a struggle concerning the cognitive understanding of risk-generating activities, and the question is to what extent the cognitive understanding of nuclear companies will be accepted among the affected local population and to what extent the local population will develop and maintain an alternative cognitive understanding.
The Compromised Researcher
Authors: Griffin Gabriele
Published: May 2022

This article centres on issues of vulnerability and being compromised in feminist research where the focus has frequently been on researching the same. Compromise, here used in its pejorative sense, may for instance occur in terms of one’s research topic, the methods one utilizes, or the participants chosen for a study. Drawing on a range of examples including the methodological work of Ann Oakley (1981, 2000) as well as three articles on researching men that appeared in the journal Signs in 2005, I argue that feminist researchers, possibly because they work in an identity-based discipline, may be diversely vulnerable when researching the same and/or researching the different, and can be compromised both by how they are treated by those whom they encounter in their research and by their own behaviour in that context. I suggest that these concerns are under-articulated in feminist research and conclude with a series of questions that need to be raised.
Women have a stronger say in couples’ decisions to have a child
Authors: Duvander Ann-Zophie , Brandén Maria , Fahlén Susanne , Ohlsson-Wijk Sofi
Published: May 2022

Sweden stands out as a forerunner in the development of gender equality and family dynamics. To deepen the knowledge on power distribution and gender dynamics of couple relations, we investigate how women and men’s childbearing intentions influence actual childbearing behavior. The Young Adult Panel Study (YAPS) has information on both partners’ childbearing intentions in 2009, which we follow for five years with register data on childbearing. The results indicate that women’s childbearing intentions are more important than men’s intentions in determining actual childbirths.
Popular peers and firstborn siblings are better off
Authors: Almquist Ylva B , Modin Bitte
Published: May 2022

‘The apple doesn’t fall far from the tree’ is an idiom that ultimately is reflected in the reproduction of inequality patterns across generations. Representatives of the child’s own generation, such as siblings and peers, may however play a key role by either reinforcing or counteracting this reproduction. Based on a Stockholm cohort now approaching retirement, we explore whether the inheritance of parents’ misfortunes, here reflected through poverty, varies in strength depending on the cohort members’ position in the sibship or peer group.
The changing political landscape of Sweden
Authors: Elgenius Gabriella , Wennerhag Magnus
Published: May 2022

The political landscape in Sweden has undergone considerable changes in recent decades The number of political parties in the Swedish parliament has increased from five to eight, and the socio-economic issues of the traditional political right–left scale has been challenged by socio-cultural issues relating to lifestyle and identity. Notably, the notion of Swedish exceptionalism and the particularities of its welfare state is lingering despite findings pointing in the opposite direction e.g. with the increased electoral support for the radical right, and its ethno-nationalist and anti-immigrant rhetoric. The corporatist model has been challenged by new forms of political authority, participation and representation. New political actors, such as social movements and civil society actors, think tanks and policy professionals, are becoming increasingly engaged in political processes. The long-term trend suggests that traditionally marginalised groups, such as the young, women and groups of migrant background, are represented in decision-making forums to a higher degree than before. Yet, current conditions need further analysis. In this article, we provide a background to Sociologisk Forskning’s special issue on the political landscape of the parliamentary election in 2018.
Unveiling the radical right online
Authors: Törnberg Anton , Wahlström Mattias
Published: May 2022

Radical right online discussion groups have grown in importance in the Swedish political landscape, yet the dynamics of these groups are still poorly understood. Apart from their topical import, these groups provide a unique entrance to grassroots discourses of the radical right movement and the mechanisms for radical nationalist mobilization. In this paper, we present an analysis of the largest current anti-immigrant online discussion group in Sweden by using a combination of quantitative and qualitative content analysis. We argue that this type of social media group needs to be approached as both a “counterpublic” within a wider public sphere and as a “free social space” for social movements. The analysis reveals that the use of external links in the group reflects an active negotiation of frames that both confirm and contradict those of the group, thereby challenging a simplistic understanding of the so-called “echo chamber” dynamics. A form of collective identity can be discerned, mainly through the opposition to various outgroups and through an implicit form of nationalism expressed through the concern of “sacred objects” typically perceived to be under threat.
Time to clean
Authors: Ambjörnsson Fanny
Published: May 2022

Cleaning is a practice with low status. Most people single out cleaning as the least attractive of household chores and the people who clean as a profession are usually badly payed. This article is an attempt to discuss why these practices have such a bad reputation – in everyday life, in work, in popular culture and, not the least, in the feminist movement. Through ethnographic data primarily based on interviews, I investigate the historically imbedded meanings tied to practices of tidying up. Drawing on theories of queer temporality, I highlight what I want to call the temporality of cleaning – the repetitiveness and direction backwards and sideways instead of forward – as a possible answer. The circular practice of taking care of our physical remains remind us of our approaching death, rather than of progress, and thus generates feelings of anger and despair. But instead of ignoring or avoiding this reminder of another time, I argue for a feminist appraisal of the temporality of cleaning.
Makt och motstånd i rehabiliteringsprocessen
Authors: Wall Erika , Selander John , Bergman Jonny
Published: May 2022

Syftet med denna studie är att nå en djupare förståelse för rehabiliteringsprocessens ambition om tidig återgång i arbete och vad detta innebär för långtidssjukskrivna kvinnor. En diskursanalys, baserad på myndighetsmaterial och svaren på en öppen enkätfråga visar, hur makt och motstånd framträder i materialet och hur sjukskrivna görs till passiva mottagare av rehabilitering och/eller definieras som långsamma i relation till de normer som återfinns som del av rehabiliteringsprocessen. Mot detta gör de långtidssjukskrivna kvinnorna motstånd. Vi menar att det finns behov av en variation inom ramen för rehabiliteringsprocessen med större möjligheter för långsammare processer för dem vilka har behov av mer tid för att tillfriskna, det finns behov av att återgå i egen takt.
Imagined independence among highly skilled Swedish labour migrants
Authors: Wallinder Ylva
Published: May 2022

The political discussion on intra-European mobility differentiates between mobile, interna- tionally employable individuals and immobile, locally employed ones. Mobile EU citizens, in turn, are subdivided into “attractive” highly skilled workers and “unwanted” lower skil- led workers. Transnational labour mobility among the highly skilled often results from an individual’s free will to move, disregarding structural reasons. This article examines the expectations and experiences of highly skilled Swedish labour migrants seeking qualified employment in Germany and the UK, exploring their strategies and modes of handling the mismatch between expectations and actual experiences. The findings demonstrate that the vulnerability migrants experience while working abroad does not seem to affect their self-understanding of being independent, flexible and highly mobile European citizens. The interviewees’ self-understanding is therefore conceptualised as an imagined independence, and one that stands in sharp contrast to their experiences of vulnerability and unexpected dif- ficulty in the host country.
Psychoactive drugs and the management of time
Authors: Hilte Mats
Published: May 2022

The main objective for this article is to explore how users of psychoactive drugs experience time and the role psychoactive drugs play in the management and construction of time. The data in this study consists of different kinds of written documents such as anecdotal accounts and scientific articles and reports which was collected using a purposeful sampling technique. One important result is that time is experienced and constructed differently among users of legal drugs compared to users of illegal drugs. The use of heroin is for example associated with shrinking time-horizons and being afraid of looking back and looking ahead, while smoking cigarettes is correlated with killing chronological time and instituting a parenthesis in normative time. Another conclusion is that users of illegal drugs experience greater problems synchronizing social and subjective time compared to users of legal substances. The results of my study also suggest that drug users´ experiences of time are intertwined with the social context and social meanings of drug use.
Time, power and resistance: Guest editors introduction
Authors: Sørensen Majken Jul , Heikkinen Satu , Alfredsson-Olsson Eva
Published: May 2022

Time, power and resistance are all central sociological concepts, but only rarely have the intertwi- ning between all three been explored. Here the guest editors of the special issue of Sociologisk Forskning called ”Time, power and resistance” introduce five empirical research articles. The articles all investigate time and temporality in relation to forms of power, ranging from discursive power to dominant norms and state power. The resistances vary from organised, collective resistance to subtle and discreet forms of everyday and constructive resistance. Additionally, the guest editors point towards future avenues of research in the area and show sociologically interesting links between the three concepts.
Common Causes Of Jaw Bones Swelling Among Yemenis (A Prospective Descriptive Hospital Based- Study)
Authors: AL-Zamzami Ali Ali
Published: May 2022

Objective: The aims of this study were to determine the common causes of jawbone swellings, common affected sites, the relationship of these causes to the age, gender of the patients and compare the findings of this study with many previous studies from various countries.

Material and methods: The study design as a prospective descriptive hospital-based study, carried out at Al-gomhori teaching hospital in Sana'a Republic of Yemen. Material consists of 125 patients who attending to the department of oral and maxillofacial surgery and to the consultant unit of head and neck oncologic surgery and diagnosed clinically, radiographically as having jawbone swellings. Histopathological results of biopsy were used to confirm the diagnosis. Data; were collected from clinical examination of the patients (interview, inspection and palpation of the suspected swelling), patient history(using questionnaire sheet), radiographs and histopathological examinations. They entered the computer and analysis using statistical package for social science (SPSS) version 24. Results; were presented as simple frequencies and descriptive statistics. Chi-square test used to assess the association and the level of significance among categorical variables. P-value less than 0.05 were considered to be statistically significant.

Results: Sixty eight of 125 patients(54.4%) were males and 57 (45.6%) were females, giving a male to female ratio of 1.2:1. Patients age ranged from 3 to 80 years with a mean age of 28.8 years ± 17.9 years. The majority of patients (80.0%) were in their 1st to 4th decades of life, with a peak incidence(40.8%) was found in the third and fourth decades of life. The most common causes of jawbone swellings were, jaw cysts, benign tumors (odontogenic and non-odontogenic tumor/tumor like-lesions) and malignant tumors, accounting 40.0%, 39.2% and 20.8% respectively. Conclusion: Jawbone swellings were observed more commonly in male patients, with a male to female ratio of 1.2:1 They may be found on any age of patients, with average age of 28.8 years (age range from 3-80 years). Jaw cysts were the most common causes of jaw bones wellings, following by benign tumors (odontogenic and nonodontogenic tumor/ or tumor lick-lesion) and malignant tumors which accounting 40.8%,39.2% and 20.8%.
Research Progress Of Spatial Transcriptomics In The Field Of Laryngeal Cancer And Other Tumors
Authors: Hong Guo
Published: May 2022

Multicellular organisms with different tissues and organs are three-dimensional complex life forms with both temporal and spatial specificity of gene expression. While temporal specificity can be obtained through assays and analyses at different time points, spatial specificity has only just been investigated at the macroscopic organismal level. Recent developments in single-cell sequencing technologies have enabled high-throughput analysis of spatially specific gene expression studies at the cellular level, and thus high-precision spatial transcriptomics studies are just beginning to emerge as the next frontier in histology. In this paper, we review the recent progress of spatial transcriptomic techniques in the field of laryngeal cancer and other tumors, which has implications for the exploration of the pathogenesis of laryngeal cancer and other malignancies.
Anomalous Presentation Of A Renal Angiomyolipoma
Authors: Xanicia Long Jiahuan
Published: May 2022

Angiomyolipoma (AML) of the kidney is a benign hamartomatous neoplasm which is usually asymptomatic and picked up incidentally on radiological imaging. AMLs that present symptomatically are typically those of large sizes exceeding 4cm with complications of rupture and retroperitoneal bleed. The classical triad in symptomatic cases includes flank pain, flank mass and gross hematuria. In cases of severe hemorrhage, patients may even turn hypotensive. AMLs rarely present as fever or urinary tract infection. This report presents a case of a middle-aged lady who presented with fever and symptoms of urinary tract infection, with urine tests suggestive of a urinary tract infection. Radiological investigations revealed a right-sided renal AML. This report discusses how renal AMLs can present atypically and includes a review of literature.
Incident Of Vitamin D Deficiency In Derna City\libya
Authors: Eljamay Salwa Muftah
Published: May 2022

The study explained the incident of vitamin D deficiency in Derna city, in the Eastern part of Libya.

Aim: To find out the causes of Vitamin D deficiency.

Material and Methods: Cross-sectional study for 590 samples were given a questionnaire, about demographic characters started in 01\05\2018 up to 15\ 01\2020.

Result: A 590 case were 360 who suffering from Vit D deficiency, that the frequency & the percent % of skin color, was the highest percent for wheaten skin color by 164 (45.6%), followed by white color skin 122 (33.9%), brownish color by 68 (18.9%), then black skin color by 6 (1.0%), Mean (2.15), SD (0.917), as followed by Smoking were 94 (26.1%) not smoking 266 (73.9%), Mean 1.74, SD (0.440), about sporting the percent was who keep exercising were 144 (40.0%), the percent who do not continue to exercise were 216(60.0%), the percent who do not exercise was 164 (45.6%), Mean (1.60), SD (0.491). As for the percent whose expose to sun were 103(17.5), then who not expose to sun were 213(36.1), who Sometimes exposed to the sun were 274(46.4), Mean (2.31), SD (0.710), p–value=0.000 that their relationship between Vitamin D Deficiencies and demographic characters, skin color, smoking, sporting, nutrition, expose to sun, diabetes, and hypertension.

Conclusion: The obtained results prove that their relationship between, age, gender, skin color, smoking, nutrition, expose to sun, sporting, diabetes, hypertension, different type of diseases, and other type of vitamins, there is also a direct proportion between vitamin D deficiency and S.Ca+ deficiency.
Evaluating The Ease-of-use Of Genotropin Go Quick Disposable Injection Pen For Treatment Of Short Stature In Paediatrics
Authors: Al-Agha Abdulmoein E
Published: May 2022

Objective: To evaluate the patient perception of the ease of use associated with Genotropin Go Quick disposable injection pen for the treatment of pediatric short stature and growth hormone deficiency.

Methods: This is a descriptive study including patients between 2-18 years of age undergoing GH treatment using Genotropin Go Quick for a minimum of 6 months. Data were collected through a personal interview in pediatric endocrinology clinics and questions were answered by those primarily administering the medication. Subjects were asked to grade the difficulty of each of the 9 steps involved in setting up Genotropin Go Quick pen at the start of treatment, 3 months, and 6 months after on a scale of very easy, somewhat easy, neutral, challenging, or difficult.

Results: A total of 310 patients were included of whom 48.4% were female. At the start of treatment, 28.8% found its use easy whereas 71.6% found it difficult. After 3 and 6 months, 81.9% and 86.8% found its use to be easy whereas 14.8% and 12.3% still found it difficult, respectively. The hardest steps identified were premixing of Genotropin solution and removal of trapped air, whereas the easiest steps were disposal of the pen or its associated parts, attaching the needle guard, and injecting the dose. 99% found storing Genotropin Go Quick and 97% found transporting it while traveling to be very easy.

Conclusion: Ease of use of an injection device is essential to ensure optimal treatment outcome and duration, minimal metabolic consequences, and avoid unnecessary high treatment costs. The majority perceived Genotropin Go Quick as difficult to use at the start of treatment yet easy after 3 months. The two most challenging steps were identified as premixing the solution and removing trapped air. Genotropin Go Quick almost unanimously was considered easy to store and transport when traveling.
Post-intubation Tracheoesophageal Fistula In Severe Sars-cov-2 Covid-19 Patient: An Unexpected Finding During Swallowing Test
Authors: Elli Fabrizia
Published: May 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-Cov2) has cause the COVID-19 pandemic that had led to an increase in intensive care unit admission for massive interstitial pneumonia. Many patients underwent mechanical ventilation and endotracheal intubation for a prolonged period of time followed by a subsequent tracheostomy. The most common complications related to these maneuvers are stenosis, malacia, laryngotracheal granulomas, webs. The least common complications are tracheal necrosis due to tracheo-arterial or trachea-esophageal fistulas, caused by compression between the nasogastric tube and the orotracheal tube cuff.

A case of 58-year-old female COVID-19 patient with severe pneumonia who underwent prolonged mechanical ventilation and intubation and for two months with unexplained episodes of food inhalation. During the swallowing test, it was observed inhalation, without natural passage of food from the glottic plane. Therefore, ENT specialist in swallowing, suspecting the feared tracheo-esophageal fistula, requested a double contrast esophageal x-ray that confirmed the diagnostic hypothesis. Thoracic surgery team performed surgical correction by resection and tracheal anastomosis with esophagoraffia.

TEF is a very rare, but potentially fatal, complication of invasive VM. Predisposing factors are prolonged periods of invasive VM, elevated cuff pressures, oversized endotracheal tubes, patient comorbidities, local and general infections, use of a nasogastric tube.

The endoscopic swallow test is a relatively simple test, performed at the patient's bed, that can identify oropharyngeal swallowing disorders and esophageal changes, such as tracheoesophageal fistula.
Remove Pediatric Telemedicine Face To Face Contact?
Authors: Bittmann Stefan
Published: May 2022

Telemedical methods are increasingly used worldwide. Since coronapandemic, telemedicine settings were used to examine, diagnose and treat children with different diseases. We focused on an innovative approach of telemedicine to examine, diagnose and treat abdominal pain in 120 pediatric patients.
Recent Electrochemical Methods Proposed for the Detection of Hepatitis C Virus. A Minireview
Authors: Ilie-Mihai Ruxandra-Maria , Staden Raluca-Ioana Stefan-Van , Staden Jacobus(Koos) Frederick Van , Aboul-Enein Hassan Y.
Published: May 2022

Hepatitis C virus is very common amongst population infected with viral hepatitis. A very important point before deciding on the correct treatment is the stage of illness. More people are detected too late, and therefore the treatment was not efficient. A highly sensitive and selective screening system for early detection is needed in order to cure the patient cured. Therefore, this review is summarizing new methods of detection of specific biomarkers/genotypes for viral hepatitis C, to help find the highest sensitive screening methods that may influence the decision of the most efficient treatment.
Introduction of Defence Response in Papaya (Carica papaya) Against PRSV Through Organic and Inorganic Chemicals as Inducers
Authors: Chaves-Bedoya Giovanni , Ortiz-Rojas Luz Yineth , Ochoa-Alejo Naftali
Published: May 2022

The use of molecules that promote plant defence mechanisms turn out to be an alternative in disease management in agriculturally important crops contributing to the reduction of pesticide use. The activation of the defence responses in plants constitute a promising tool for the control of diseases in conventional agriculture. The results of the effect of a Chamomile aqueous extract as organic inducer and a sulphur-based fungicide as inorganic chemical inducer, as well as their combination, on the induction of resistance-related PR1 and MPK1 genes are presented in this work. In vivo results show a deleterious effect of the organic inducer in papaya plants. However, this effect decreased when combined with the sulphur-based compound, which also reduced the severity of symptoms caused by PRSV. Our results indicate that the combined treatment generates a similar response in plants to that produced by Salicylic Acid in the induction of PR1 expression.
Pocket Milling of AISI 1045 Steel using Abrasive Water Jet Machining by Varying Contours
Authors: Umapathy Vishnuja , Bhavani Bhaskar Govindaswamy
Published: May 2022

Abrasive water jet machining (AWJM) is an innovative machining technology recognized for cutting tougher materials smoothly. This study investigates the significance of AWJM parameters on surface roughness (SR) and material removal rate (MRR); while machining AISI1045medium carbon steel. Pocket milling has been done on the material; pockets of definite size/specifications are machined and associated MRR and SR are investigated. The Input parameters considered are Standoff distance (SOD), Cutting feed, Pressure. Experimental parameters are analyzed as per Taguchi method (DOE). The interaction effects of input process parameters are studied through 3D contour plots. ANOVA is used to determine the influencing parameter, and it has been verified that the ideal combination of Taguchi process parameters satisfies the actual machining of material.
Study of diazepam effects on Ehrlich ascites carcinoma and anxiety responses in male SHK mice
Authors: Kalinina T. S. , Shimshirt A. A. , Lisitskaya K. V. , Volkova A. V. , Kudryashov N. V.
Published: May 2022

Сomorbidity of malignant tumors and affective disorders is an urgent problem. It is known that some psychotropic drugs may adversely influence the growth of malignant tumors and metastasis; in the experiment, a connection between neurotransmitters and tumors was established. Earlier, in experiments on mice, the ability of diazepam to stimulate the growth of Ehrlich's ascites carcinoma was demonstrated.

   The aim of this study was to assess the role of central and peripheral benzodiazepine receptor sites in the stimulating effect of diazepam on Ehrlich's carcinoma. The effects of diazepam (0.03 and 3.0 mg / kg, intragastric) on the development of Ehrlich's ascites carcinoma and an orientation-exploratory response in the "open field" test on male SHK mice were studied. It was found that diazepam at a dose of 0.03 mg / kg, but not at a dose of 3 mg / kg, increases the cellularity of the malignant ascites. At the same time, diazepam in both doses studied causes an increase in the peripheral motor activity of mice, which indicates an increase in anxiety reactions. It was found that flumazenil, but not PK11195, attenuates the stimulating effect of diazepam on Ehrlich's ascites carcinoma and inhibits the pro-anxiogenic effect of a small dose of diazepam. The results obtained allow us to conclude that there is no associative relationship between the pro-tumor effect of diazepam and its effect on anxiety responses, but at the same time, the participation of central mechanisms in the stimulating effect of benzodiazepine on the tumor cannot be ruled out.
Comparative study of the effects of adamantane derivatives on the behavior of CD-1 mice with different phenotype of attention stability
Authors: Sukhorukova N. A. , Salimov R. M. , Kovalev G. I.
Published: May 2022

The effect of memantine (1 and 10 mg/kg/day), ladasten (50 mg/kg/day) and cyclantane (10 mg/kg/day) on the behavior of CD-1 mice differing in the phenotype of attention stability in the "closed enriched cross maze" test after three days of intraperitoneal administration was studied. It was found that in a subpopulation of mice with an initial attention deficit, these aminoadamantane derivatives partially restored the level of attention. The drugs equally worsened attention in a subpopulation with an initially high attention index by 40–47 % relative to the control, which indicates the absence of selectivity of the effect of these drugs with respect to attention deficit. However, this effect was not accompanied by a change in exploratory and locomotor activity, which makes it possible to make an assumption about the prospects for further study of the pharmacological effects of adamantane derivatives and optimization of their dose and duration of administration.
The clinical-economic characteristic of current basis-bolus insulin therapy schemes in diabetes mellitus type 1 in adults
Authors: Kolbin A. S. , Kurilev A. A. , Balikina Y. E. , Proskurin M. A.
Published: May 2022

Basis-bolus insulin therapy is a cornerstone of Diabetes Mellitus type 1 (DM1T) control. Basal insulin analogs — glargine 300 U/ml (iGla 300), glargine 100 U/ml (iGla 100), detemir (iDet) degludec (iDeg), — as well as prandial insulins — glulisine (iGlu), aspart (iAsp) and lispro — are used widely during last 10–15 years. Aim. Evaluation of a comparative economic efficacy of the different basis-bolus schemes of insulin therapy in DM1T in adults. Materials and methods. Analysis has been performed for the following schemes: iGla 300 + iGlu, iGla 100 + iGlu, iDet+iAsp, iDeg+iAsp from Govt position based on modelling of the efficacy for 5 years. Data regarding probability of complications based on glycated hemoglobin (HbA1c) reduction for human insulin treatment and insulin analogs were taken into modelling. Direct medical costs were calculated for insulins, complications, hypoglycemic including severe events. Sensitivity analysis has been performed for validation of the received results. Results: Insulin analogs have economic advantages in compare with human insulins for DM1T control for 6.5 years. They could reduce expenditures in 1.89 times. iGla 300 + iGlu and iDeg+iGlu reduced HbA1c more effective among analogs and hypo events were more rare also (35.0 episodes/patient/year), including severe (0.57 and 0.70 episodes/patient/ year accordingly) vs iGla 100 + iGlu and iDet+iAsp (37.8 and 39.9 episodes/patient/year and 1.10 and 1.21 episodes/patient/ year for severe accordingly). Calculated direct medical costs were less for iGla 300 + iGlu, after that were following iGla 100 + iGlu, iDet+iAsp and last (highest) were expenditures for iDeg+iAsp. Conclusion. Created model prognoses complications of DM1T depending on schemes of insulin therapy and calculates of direct costs. iGla 300 + iGlu has economic advantages vs iGla100 + iGlu, iDet+iAsp and iDeg+iAsp in DM1T control during 5 years horizon.
Drug-induced pulmonary artery hypertension
Authors: Ostroumova O. D. , Listratov A. I. , Kochetkov A. I. , Bliznyuk S. A. , Komarova A. G. , Sychev D. A.
Published: May 2022

Pulmonary arterial hypertension is a condition characterized by an increase in mean pressure in the pulmonary artery. This pathology is associated with high mortality, and specific therapy for pulmonary arterial hypertension does not affect the cause of the disease and is extremely expensive. In this regard, it is especially important to study the modifiable etiological factors of pulmonary arterial hypertension. One such factor is drugs. One of the leading groups of drugs-inductors is anorexigenic drugs. It was the representatives of this group, such as aminorex, who were the first inducers of pulmonary hypertension. Moreover, this adverse reaction was so significant that it led to the withdrawal of these drugs. Currently, the leading role in the context of drug-induced pulmonary hypertension is played by such drugs as anticancer, antiviral drugs, and interferons. These drugs lead to pulmonary hypertension through various pathophysiological mechanisms. The leading measures to prevent this pathology are to limit the use of culprit medications, reduce the spread of HIV infection, since several groups of drugs can be used to treat HIV-infected patients, leading to the development of pulmonary hypertension.
Effect of Communual Clash on Agricultural Production in Awka North Local Government Area of Anambra State
Authors: Okafor  , Esther Ogochukwu , Chioma Ngene Ngozi
Published: May 2022

The manifest communal clashes in the State necessitated this study to investigate the effect of communal clash on Agricultural production, using Awka North Local Government Area as a yardstick. A survey research design was employed in the study. The population of the study consisted of 927 Cooperative farmer members in Awka North and the sample size was 101 using Taro Yamane formula. Questionnaire was used in collecting data. Data were analyzed using Multiple Regression at 5% level of significance. Findings showed that there is a statistical significant relationship between communal clash and agricultural output (r = 0.19, R2 = 0.22, F = 0.0001, p-value < 0.05) and that boundary dispute has inverse relationship with agricultural output (r = 0.03, R2 = 0.07, F = 0.1137, p-value > 0.05). Consequently, the study concluded that communal clash has altered agricultural production in Awka North Local Government Area. Therefore, the study recommended among other things that Anambra State government need to make policies that would enhance peaceful coexistence among the communities in Awka North local Government Area to enable farmers in the area attain their full potential in agricultural production. Anambra State Ministry of Agriculture needs to intensify efforts in the provision agricultural inputs such as fertilizers so as to enhance soil manure for increased agricultural production
Notes: The Strange Nature of Light
Authors: Maccinia Anthony
Published: May 2022

The purpose of this paper is to show that contrary to the conventional view of the nature of light, its behaviour is far stranger than has been considered. Here presented it is shown that time is frozen from the reference frame of a photon, that the phase velocity of light is superluminal. And also light is superluminal in the nearfield of the source of a transmitter, and that advanced waves have been detected. The principle of least action is reflected in lights behaviour in the quantum domain, and conservation laws may apply for advanced waves travailing into the past. These aspects of light, known by scientists, but presented all together show how strange the nature of light really is, and that a new model needs to be addressed on the behaviour of light.
Perceptions and Logics of Appropriation of the Practice and Use of Compost in Agricultural Production Systems in Western Burkina Faso
Authors: FAYAMA Dr. Tionyélé
Published: May 2022

Observations of the degradation of the environment and the vegetation cover have led rural populations to become aware of the harmful effects of chemical fertilizers. More and more voices call for the abandonment of these fertilizers of chemical origin and their replacement by those resulting from the bio-organic decomposition of bio-vegetable elements. This process is known as composting. Even if it is beneficial, composting is nevertheless little practiced by peasant populations. If so, one wonders what the current perception of this practice is. This research has made it possible to travel through thirteen villages in the HautsBassins region using qualitative approach. Four focus groups, twenty semi-structured interviews, and observations were carried out with various actors from the rural world. A documentary review was also used. This research shows that farmers place great trust in the use of compost, to the detriment of other chemical fertilizers. However, they face several difficulties related to this practice. The provision of a mobile crusher and the training of farmers will solve a large part of the difficulties they encounter. This study demonstrates that farmers put a high premium on compost at the expense of other chemical fertilizers. However, they do confront several issues because of this behavior. The provision of a mobile crusher and training for farmers will alleviate many of the issues they face.
Impact of Community Development Programmes on Leadership Capacity Building of Community Leaders in Bayelsa State, Nigeria
Authors: BRUCE  , Esther Seagirl , KOBANI  , Doreen
Published: May 2022

This Study examined Community Development Programmes and Leadership Capacity Building of Community Leaders in Bayelsa State of Nigeria. The study adopted a descriptive survey design. The population of the study comprises the 1,294 Paramount Rulers and Community Development Committee (CDC) Chairmen in the state. The simple random sampling technique was applied to select 200 respondents from each of the senatorial districts that make up Bayelsa State (Bayelsa Central, Bayelsa East and Bayelsa West) to realize a sample size of 600. The instrument used for data collection was a questionnaire. The reliability coefficient index of the instrument was 0.85. Three research questions were posed. They were analyzed using frequencies and weighted mean. The findings revealed amongst others that: cultural education programmes, environment/sanitation education programmes and peace/conflict resolution education programmes build the capacity of Community Leaders on cultural values for peaceful coexistence amongst others. Based on the findings, the Researcher recommended amongst others that: Paramount Rulers and Community Development Committee (CDC) Chairmen should recommend to the state government on adding peace education to the primary and secondary school curriculum as this would bring lasting peace to the various local government areas of Bayelsa State and Nigeria at large.
Digitale Fabrikplanung als Befähiger zur Erreichung der Klimaziele/Scalable factory and production concept for the production of water electrolysers
Authors: Burggräf Peter , Adlon Tobias , Beyer Moritz , Xu Tingni , Lehde genannt Kettler Nils , Koc Rana
Published: May 2022

Der prognostizierte Bedarf nach Wasserstoff für industrielle, energetische und mobile Anwendungen bedingt deutlich erweiterte Herstellungskapazitäten. Die Produktionen von Wasserelektrolyseuren wiederum sind jedoch gekennzeichnet durch eine teilautomatisierte Einzelfertigung, die den erwarteten Absatzzahlen nicht gerecht wird. Dieser Beitrag skizziert einen strategischen Entwicklungsplan, um mittels digitaler Fabrikplanung skalierbare Fabrik- und Produktionskonzepte für Elektrolyseure zu erarbeiten. Im Anschluss werden zu untersuchende Handlungsfelder abgeleitet.

 

The projected demand for hydrogen for industrial, energetic and mobile applications causes an urge for production capacities. Though the productions of such electrolysers are currently characterised by a partially automated single-unit production, which does not meet the projected sales volumes. This paper outlines a strategic development plan to elaborate scalable factory and production concepts for electrolysers by means of digital factory planning. Finally, fields of action to be investigated are beeing derived.
Abordaje cualitativo en la búsqueda de un contexto para la enseñanza de las matemáticas en conjunto con la robótica educativa: Ludobot y sus posibilidades pedagógicas en los primeros años de la escuela primaria
Authors: Oliveira dos Santos Érica , Schneider Gross Giane Fernanda , Machado Albertoni Neumar Regiane , Kalinke Marco Aurélio
Published: May 2022

En este artículo se analiza una de las intenciones de la investigación cualitativa sobre la objetivación del fenómeno, con el propósito de detallar el camino entre las acciones de describir, comprender y explicar las posibilidades pedagógicas con un determinado kit para el trabajo con Robótica Educativa (ER), denominado Ludobot, y la enseñanza de las Matemáticas. Esta investigación de abordaje cualitativa, de tipo descriptiva, fue realizada utilizando el análisis de datos de un estudio de maestría profesional, que trata del uso de ER en los primeros años de la escuela primaria. En el análisis se evidencia la perspectiva de una investigación cualitativa en Educación Matemática, que buscó profundizar la comprensión de los fenómenos investigados en relación con el contexto en que ocurren. El transcurso de la investigación denota la importancia de percibir los fundamentos teóricos subyacentes a la práctica de la ER y el trabajo docente más allá de las posibilidades de recursos (o kits) a ser utilizados. Se entiende que el enfoque metodológico presentado en la investigación de Santos (2020) fue fundamental para señalar bases teóricas y científicas para la elaboración de un producto educativo y demostró que en la investigación cualitativa el investigador necesita tener sensibilidad para acercarse a su objeto de estudio, buscando establecer relaciones de investigación y, a veces, distanciarse de ella, de modo que sea posible observar diferentes aspectos y enfoques.
Características fundamentales del trabajo con Modelación Matemática en el ámbito de la Educación Matemática
Authors: Tambarussi Carla Melli , Viggiani Bicudo Maria Aparecida
Published: May 2022

La pregunta que nos mueve en la articulación de este texto se centra en lo qué caracteriza el trabajo con la Modelación Matemática en la Educación Matemática. La indagación busca comprender los aspectos que se abren y que implican trabajar con la MM en el aula. Los datos producidos para la investigación se refieren a entrevistas con sujetos significativos que trabajan con Modelación Matemática en la Educación Matemática. Los análisis fueron guiados por procedimientos de investigación cualitativa, guiados por la visión fenomenológica. Las discusiones que presentamos indican que la Modelación Matemática en la Educación Matemática como horizonte abierto de posibilidades de enseñanza y aprendizaje, las matemáticas y la realidad, los aspectos concernientes al modo de ser del estudiante, presentes también en la acción ciudadana, la formalización e la interdisciplinariedad son aspectos característicos del trabajo con Modelación Matemática en situaciones de enseñanza y aprendizaje.