bluuebunny/crossref_metadata_2025 huggingface dataset:
The impacts of the EU carbon border adjustment mechanism on China
Authors: Wenmei Kang , Wang Mou
Published: November 2023

The EU is China's second-largest commodity exporter. As the object of taxation via CBAM, discussing the impact of CBAM on China can provide a data basis for China to deal with the EU’s carbon border adjustment mechanism. Based on the analysis of the export trade relationship between China and the EU, this study uses the input-output model to calculate the embodied carbon of China's exports to the EU. In addition, the overall and industrial impact of CBAM on China's exports to the EU is compared and analyzed in four scenarios from the perspectives of direct and indirect carbon and embodied carbon, and the research shows that: (1) the machinery and equipment manufacturing industry is the industry with the most embodied carbon in China's exports to EU, accounting for 41.63%, and the seven industries, i.e. iron and steel, aluminum, fertilizer, cement, chemicals, polymers and electricity, covered by CBAM account for 10.89%; (2) Based on the taxation industry and taxation scope proposed by CBAM adopted on June 22, 2022, and under the current EU ETS carbon price of €70/ton, China will be levied $1.23 billion; (3) According to the taxation scope and taxation industry that may be expanded in the future mentioned in the CBAM proposal, that is, the expansion of CBAM tax scope from direct and indirect carbon to embodied carbon, and the expansion of industries from seven major industries to all industries of the China's export to the EU, the impact on China's exports to the EU is becoming more and more serious, the largest impact is 28 times that of the current proposal. In particular, the industries of machinery and equipment manufacturing, textiles, clothing, shoes, hats, leather, down feather and their products, woodworking products, furniture, and construction, where the impact of embodied carbon emissions is 16 times, 20 times, 56 times, and 14 times that of direct and indirect carbon emissions, respectively. Although these industries are not covered by the current CBAM text, they should not be ignored in the event of the taxable industries expanding in the future.
Applying Optimized YOLOv8 for Heritage Conservation: Enhanced Object Detection in Jiangnan Traditional Private Gardens
Authors: Gao Chan , Zhang Qingzhu , Tan Zheyu , Zhao Genfeng , Gao Sen , Eunyoung Kim , Shen Tao
Published: November 2023

This study aims to promote the protection and inheritance of cultural heritage in private gardens in the Jiangnan area of China. By establishing a precise visual labeling system and accelerating the construction of a database for private garden features, we deepen the understanding of garden design philosophy. To this end, we propose an improved Jiangnan private garden recognition model based on You Only Look Once (YOLO) v8. This model is particularly suitable for processing garden environments with characteristics such as single or complex structures, rich depth of field, and cluttered targets, effectively enhancing the accuracy and efficiency of object recognition.This design integrates the Diverse Branch Block (DBB), Bidirectional Feature Pyramid Network（BiFPN）, and Dynamic Head modules （DyHead）to optimize model accuracy, feature fusion, and object detection representational capability, respectively. The enhancements elevated the model's accuracy by 8.7%, achieving a mean average precision (mAP) value of 57.1%. A specialized dataset, comprising 4890 images and encapsulating various angles and lighting conditions of Jiangnan private gardens, was constructed to realize this. Following manual annotation and the application of diverse data augmentation strategies, the dataset bolsters the generalization and robustness of the model. Experimental outcomes reveal that, compared to its predecessor, the improved model has witnessed increments of 15.16%, 3.25%, and 11.88% in precision, mAP0.5, and mAP0.5:0.95 metrics, respectively, demonstrating exemplary performance in the accuracy and real-time recognition of garden target elements. This research not only furnishes robust technical support for the digitization and intelligent research of Jiangnan private gardens but also provides a potent methodological reference for object detection and classification research in analogous domains.
Survival study of small cell neuroendocrine carcinoma of the bladder: an analysis using data from the SEER Program
Authors: Wu Jinwen , Zeng Qi
Published: November 2023

Purpose
To report survival prognostic factors and explore the value of adjuvant therapy in patients with small cell neuroendocrine carcinoma of the bladder (SCNEC).
Methods
Data of patients diagnosed with SCNEC in published by the SEER from 2004 to 2017 were retrospectively reviewed, and survival rate and prognostic factors were statistically analyzed by the Kaplan-Meier method and Cox regression analysis. The propensity matching score (PSM) was used to balance the baseline characteristics between two group.
Results
A total of 1227 patients with SCNEC were included in this study. The 5-year overall survival (OS) rate was 21.2%, and the cancer-specific survival rate (CSS) was 30.3%. The results of univariate Cox regression analysis indicated that age, race, AJCC staging, TNM stage, surgery, and chemotherapy were significantly associated with OS and CSS. After multivariate Cox regression analysis, age over 75, race, AJCC staging VA/B, M1 stage, and chemotherapy were identified as independent prognostic factors. The PSM method was performed to balance prognostic factors and match patients. The results of subgroup analysis indicated that postoperative radiotherapy significantly decreased the OS of patients with the M0 stage (P = 0.041) or T1-2 stage (P = 0.011).
Conclusion
Age over 75 years old, race, AJCC staging VA/B, M1 stage, and chemotherapy were independent prognostic factors for SCNEC. Postoperative radiotherapy was not recommended for patients with the M1 stage or T1-2 stage.
A Generative Adversarial Network (GAN)-based Three-dimensional Rectal Cancer Pathological Complete Response Prediction Framework
Authors: Li Lanlan , Xie Chengjie , Xu Bin , Qi Jing , Li Juan , Niu Decao
Published: November 2023

Colorectal cancer affects the health of the global public, and the increasing proportion of cases has attracted widespread attention. This phenomenon has made the treatment of colorectal cancer an inevitable topic in the global medical community, and has sparked interest in using deep learning models for early detection and diagnosis of colorectal cancer. This study proposes a method based on Three-dimensional (3D) Magnetic Resonance Imaging (MRI) data to predict the complete pathological remission of rectal cancer patients. To improve prediction accuracy, we employ an improved Deep Convolutional Generative Adversarial Network (DCGAN) for data augmentation and optimize the 3D network with different attention modules. Specifically, we employed a DCGAN generator for data augmentation. Instead of using deconvolution operations as in the DCGAN generator, we utilized upsampling and convolution operations to diminish the impact of "artifacts" on the generated images. Additionally, we enhanced the image quality by utilizing an improved AlexNet-based discriminator architecture. Furthermore, we utilize the Convolutional Block Attention Module (CBAM) for feature extraction and capturing spatial and channel information. The experimental results of this study demonstrate significant improvements in accuracy, specificity, and sensitivity through the application of data augmentation and attention mechanisms. In detail, the accuracy is improved to 0.778, specificity to 0.796, and sensitivity to 0.754. Compared to the baseline network, these values have increased by 8.8%, 9.9%, and 9.1% respectively. These findings indicate that the method we propose offers a potential tool for doctors to avoid unnecessary surgical procedures.
Constructing a lactylation-related genes prognostic model to effectively predict the disease-free survival and treatment responsiveness in prostate cancer based on machine learning
Authors: Pan Jinyou , Zhang Jianpeng , Lin Jingwei , Cai Yinxin , Zhao Zhigang
Published: November 2023

Background: More and more studies have revealed that protein lactylation is an important mechanism for lactate to fulfill its duties and participate in important biological processes, which can regulate gene expressions through histone lactation, thereby promoting tumor spread, metastasis and immunosuppression. However, protein lactylation has been poorly studied in prostate cancer.
Methods: This study aimed to identify potential novel lactylation biomarkers of prostate cancer by biomarker analysis and to explore immune cell infiltration and treatment responsiveness. By downloading mRNA-Seq data of TCGA prostate cancer data for differential analysis, we obtained the differential genes related to Lactylation in prostate cancer. Five machine learning algorithms were used to screen for lactylation-related key genes for prostate cancer. The five overlapping key genes screened by five machine learning algorithms were used to construct a survival prognostic model by lasso cox regression analysis. Further, the relationships between the model and related pathways, tumor mutation and immune cell subpopulations and drug sensitivity were explored. Then, two risk groups were established according to the risk score calculated by the five lactylation-related genes (LRGs). Subsequently, a nomogram scoring system was established to predict disease-free survival (DFS) of patients by combining clinicopathological features and lactylation-related risk scores. Besides, the mRNA expression levels of five genes were verified in prostate cancer cell lines by qPCR.
Results: We identified 5 key LRGs (ALDOA, DDX39A, H2AX, KIF2C, RACGAP1) and constructed the LRGs prognostic model. The AUC values for 1 -, 3 -, and 5-year DFS in the TCGA dataset were 0.762, 0.745, and 0.709. The risk score was a better predictor of disease-free survival than traditional clinicopathological features in prostate cancer. The prostate cancer patients in the high-risk group have a higher proportion of regulatory T cells and M2 macrophage, a higher tumor mutation burden, and a worse prognosis. The high-risk group had a lower IC50 for certain chemotherapeutic drugs, such as Docetaxel, Paclitaxel.
Conclusions: The lactylation-related genes prognostic model can effectively predict the disease-free survival and therapeutic responses in prostate patients.
PointDMIG: A Dynamic Motion-Informed Graph Neural Network for 3D Action Recognition
Authors: Du Yao , Hou Zhenjie , Li Xing , Liang Jiuzhen , You Kaijun , Zhou Xinwen
Published: November 2023

Point cloud contains rich spatial information, providing effective supplementary clues for action recognition. Existing action recognition algorithms based on point cloud sequences typically employ complex spatiotemporal local encoding to capture the spatiotemporal features, leading to the loss of spatial information and the inability to establish long-term spatial correlation. In this paper, we propose a PointDMIG network that models the long-term spatio-temporal correlation in point cloud sequences while retaining spatial structure information. Specifically, we first employs graph-based static point cloud techniques to construct topological structures for input point cloud sequences and encodes them as human static appearance feature vectors, introducing inherent frame-level parallelism to avoid the loss of spatial information. Then, we extend the technique for static point clouds by integrating the motion information of points between adjacent frames into the topological graph structure, capturing the long-term spatio-temporal evolution of human static appearance while retaining the features of human static appearance. Moreover, to further enhance the semantic representation of the point cloud sequences, PointDMIG reconstructs the downsampled point set in the feature extraction process, further enriching the spatio-temporal information of human body movements. Experimental results on NTU RGB+D 60 and MSR Action 3D show that PointDMIG significantly improves the accuracy of 3D human action recognition based on point cloud sequences. We also performed an extended experiment on gesture recognition on the SHREC 2017 dataset, and PointDMIG achieved competitive results.
Evaluation of the effect of topical calcipotriol versus platelet-rich plasma versus a combination of both on patients with Alopecia Areata
Authors: Ali Mahmoud Ahmed Ali , Taieb Moustafa Adam El Taieb El , Younis Ali Mohamed Younis , Ibrahim Hassan Mohamed Ibrahim , Abdellatif Mohamed Amer Ahmed Abdellatif , Ahmed Nour Mohammed Ahmed , Ahmed Faten Othman Ahmed , Hegazy Eisa Mohamed Hegazy
Published: November 2023

Background: Alopecia areata (AA) is considered to be an autoimmune disease that has different treatment modalities. Topical vitamin D analog and PRP are recognized as effective therapies for AA. The aim of the study was a compare the effect of topical vitamin D analog (calcipotriol), intra-lesion PRP, and a combination of both on AA patients.
Patients and methods:
In this double-blinded randomized clinical trial study, a total of 39 cases (patients with AA) were divided into 3 groups: Group I (n = 13): cases received topical Vit D3 analog (calcipotriol) 0.005% twice daily for 3 months with follow up. Group II (n = 13): cases received PRP intra-lesion injection for 6 consecutive sessions 2 weeks apart. Combined Group III (n = 13):cases received both treatments. Clinical evaluation by SALT score (severity alopecia tool) and dermoscopic examination were performed before and after treatment. Study registration at clinicaltrial.com was done, approval number: NCT05954104. Date of registration: 23/6/2023.
Results:
In this study, there was a significant decrease in the mean SALT score for the three groups (p<0.001). The absolute reduction in G-I (calcipotriol) was 3.73 points, in G-II (PRP), was 6.87 points, and in G-III(combined) was 18.98 points This reduction was significant (p<0.001) more evident in G-III followed by G-II and then G-I. There was a significant reduction in Dermoscopic findings after treatment in the three groups.
Conclusion:
Significant reductions in SALT levels were observed across all three groups, with the combination of calcipotriol and PRP being particularly noteworthy. Significant reductions in dermoscopic symptoms were observed following treatment.
Determinants of Early Chronic Kidney Disease in Patients with Recently Diagnosed Type 2 diabetes mellitus: A study from the Taiwan Diabetes Registry
Authors: Yeh Yun-Kai , Lin Kuan-Hung , Sheu Wayne Huey-Herng , Lo Su-Huey , Yeh Yen-Po , Huang Chien-Ning , Hwu Chii-Min , Lu Chieh-Hsiang
Published: November 2023

Background
We tried to identify the risk factor associate with early chronic kidney disease (CKD) in recently diagnosed type 2 diabetes mellitus patients by utilizing real-world data from Taiwan Diabetes Registry.
Materials and methods
Patients with type 2 diabetes mellitus recently diagnosed within 1 year. We divided the study participants into control group and early CKD group. Early CKD was defined as either CKD stage G1 with albuminuria, CKD stage G2 with albuminuria, or CKD stage G3a regardless of albuminuria (Urine-albumin to creatinine ratio ≥ 3mg/mmol). Control group was defined as CKD G1 or CKD G2 without albuminuria. Logistic regression analyses were used to compare differences in clinical characteristics between the subgroups. Linear regression models were employed to examine the factors predicting estimated glomerular filtration rate (eGFR) and UACR.
Results
Total 2217 patients with recently diagnosed type 2 diabetes mellitus were included. 1545 patients were assigned to control group and 618 patients were assigned to the early CKD group. Age (odds ratio (OR) 1.02, 95% confdence interval [CI] 1.012–1.028), diastolic blood pressure (OR 1.019, 95% CI 1.011–1.026), glycated hemoglobin (OR 1.074, 95% CI 1.023–1.129) and triglyceride (OR 2.18, 95% CI 1.485–3.199) were found to be significant risk factors. Further, presence of bidirectional association between UACR and eGFR was found.
Conclusions
We reported factors associated with early CKD in recently diagnosed type 2 diabetes mellitus patients. Variables that associated with eGFR and UACR were identified respectively, included a mutual influence between UACR and eGFR.
The Relationship of Ultrasonic Characteristics of the Patent Foramen Ovale and Interventional Closure
Authors: Wang Yu-bo , Shan Lin , Huang Hui , Sun Jie , Liu Kun
Published: November 2023

Objective
Percutaneous interventional closure of patent foramen ovale (PFO) is the main method for the treatment of PFO. However, closure failed in some patients. This study aimed to investigate the relationship between ultrasonic characteristics of PFO and the results of PFO closure.
Method
Contrast transthoracic echocardiography (c-TTE) of right heart and transesophageal echocardiography (TEE) were performed to obtain data regarding the degree of the right-to-left shunt (RLS), the width and length of the PFO, the color shunt, the granular echo in the PFO gap, and atrial septal aneurysm (ASA). The effect of each factor on closure was analyzed by logistic regression.
Results
A total of 222 cases were included in the analysis. PFO with granular echo in the PFO gap, with ASA, grade I RLS, and without TEE color shunt had higher probabilities of failed PFO closure. Long PFO also had higher probability of failed PFO closure.
Conclusions
C-TTE and TEE ultrasonic characteristics of PFO may be indicative of PFO closure results. For patients about to undergo PFO closure, it is beneficial to observe the ultrasonic characteristics of PFO to provide patients with more ideal treatment.
Sex-specific Expression of Estradiol Derivatives, Hydropersulfides and Ether Lipids Regulates Ferroptosis Sensitivity of Kidney Tubules
Authors: Linkermann Andreas , Belavgeni Alexia , Tonnus Wulf , Maremonti Francesca , Penkov Sider , Mallais Melodie , Gaillet Christine , Brucker Anne , Schilling Danny , Schlicker Lisa , Himmerkus Nina , Gavali Shubhangi , Schlecht Marlena , Flade Karolin , Becker Jorunn , Tmava Mirela , Haag Anne , Hugo Christian , Schulze Almut , Plietker Bernd , Becker Jan , Weinberg Joel , Lorenz Svenja , Proneth Bettina , Conrad Marcus , Rodriguez Raphaël , Bornstein Stefan , Dick Tobias , Pratt Derel , Fedorova Maria
Published: November 2023

Acute kidney tubular necrosis (ATN) mediates acute kidney injury (AKI) and nephron loss, the major risk factor for chronic kidney disease (CKD) progression and end-stage renal disease (ESRD)1-3. For decades, it has been known that female tissue is less sensitive to AKI4,5, but the underlying mechanisms have remained elusive. As a specific feature, ATN is characterized by dynamic cell death propagation along the tubular compartment, mediated by ferroptosis in male mice6,7. Herein we demonstrate that ferroptotic cell death propagation is abrogated in female kidney tubules. Ferroptosis sensitivity in females was decreased by estradiol and its derivatives, which function as radical-trapping antioxidants (RTAs). Female sex-specific tubular expression of ferroptosis suppressor protein 1 (FSP1, also AIFM2) functions to regenerate the estradiol derivatives from their oxidation products, thereby potentiating RTA capacity. In addition, females exhibited much higher levels of anti-ferroptotic hydropersulfides detected directly from the most sensitive tubular compartment. In contrast, male proximal tubules express alkylglycerone phosphate synthase (AGPS) and fatty acyl-CoA reductase 1 (FAR1), key enzymes required for the generation of ether lipids which sensitize to ferroptosis. In summary, we uncover three independent mechanisms that collectively explain higher ferroptosis sensitivity of male over female tubular tissue and may function as therapeutic targets.
PIV Analysis of Wake Characteristics of Slanted-Back Ahmed Bodies: Effect of Leading-Edge Shape
Authors: Sagharichi Amir , Tachie Mark Francis
Published: November 2023

This study experimentally investigates turbulent flow separation over a slanted-back Ahmed body with different leading-edge configurations (rounded and square) using the particle image velocimetry (PIV) technique. Reynolds number (based on free-stream velocity and body height) is \({\text{Re}}_{\text{H}}\) = 0.17 × 105. Spatiotemporal flow characteristics, including mean flow, vorticity flux, spatial two-point correlation, reverse flow area, turbulent kinetic energy budget, frequency spectra, and proper orthogonal decomposition (POD) are analyzed. The results reveal a larger recirculation region near the leading edge of the square leading-edge (SL) case, associated with higher vorticity flux compared to the rounded leading-edge (RL) case. Pulsations are observed in the wake region recirculation bubbles through phase-averaging analysis of instantaneous velocity and vorticity. The auto and cross-correlation of reverse flow areas in the SL case exhibit higher temporal correlations in the leading edge and wake region. The analysis of Kelvin-Helmholtz wavelength and frequency spectra indicates a smaller wavelength in the RL case, corresponding to a higher dominant shedding frequency than the SL case. POD reveals the formation of smaller coherent structures with smaller convective velocities, and higher shedding frequency in the wake region of the RL case.
Hemp Seed Oil Derived Rigid Polyurethane Foams and Their Underlying Flame Retardancy Properties
Authors: Jariwala Sagar , Desai Yash N , Sahu Pranabesh , Gupta Ram K.
Published: November 2023

Green manufacturing and reducing our cultural dependency on petrochemicals have been the global interest currently, especially in the polyurethane industry segments. We report the fabrication of rigid polyurethane foams (RPUFs) and their flame-retardant property from hemp seed oil as an alternative to petrochemical-based polyols. The cold-pressed hemp-seed oil (HSO) was first oxidized to epoxidized triglyceride oils with acetic acid and hydrogen peroxide, followed by a ring-opening reaction with methanol to fabricate hemp bio-polyols. The formation of polyols was characterized using FT-IR, hydroxyl, and acid values. The bio-polyol was used in different proportions with commercial polyols and other foaming ingredients to produce rigid polyurethane foams via a one-step process. Dimethyl methylphosphonate (DMMP), triethyl phosphate (TEP), and expandable graphite (EG) were added during the foam preparation to improve flame retardancy. The produced foams were analyzed for their apparent density, mechanical properties, thermal degradation behavior, closed cell content, flammability, and cellular morphology. The effect of different flame retardants had a significant influence on the cellular structures, closed-cell content, density, and compressive strength of the polyurethane. A significant improvement in anti-flaming properties was observed as the neat HSO-based foam showed a burning time of 110 sec and a weight loss of 82%, whereas 10 wt.% of TEP displayed a reduced burning time and weight loss of 19 sec and 5%, respectively. DMMP and EG-based RPUFs exhibited similar flame retardancy and mechanical properties relative to neat HSO-based foam. The results demonstrated in this work proposed a potential combination of bio-polyols and commercial polyols as a strategy to fabricate flame-retardant polyurethane foam for high-performance applications.
Metabolic and genetic risk factors associated with pre-diabetes and type 2 diabetes in Thai healthcare employees: a long-term study from the Siriraj Health (SIH) Cohort Study
Authors: Mongkolsucharitkul Pichanun , Suta Sophida , Manosan Thamonwan , Surawit Apinya , Pumeiam Sureeporn , Pinsawas Bonggochpass , Pongkunakorn Tanyaporn , Ophakas Suphawan , Ratanasuwan Winai , Homsanit Mayuree , Charoencholvanich Keerati , Udomphorn Yuthana , Suktitipat Bhoom , Mayurasakorn Korapat
Published: November 2023

Background
The study of non-communicable diseases (NCDs) in a developing country like Thailand has rarely conducted in long-term cohort, especially in working-age population. We aim to assess the prevalence and incidence of risk factors and their associations underlying NCDs, especially type-2 diabetes mellitus (T2DM) among healthcare workers enrolled in the Siriraj Health (SIH) study cohort.
Methods
SIH study was designed as a longitudinal cohort and conducted at Siriraj hospital, Thailand. A total 5,011 participants (77% Female) were recruited and follow-up. Physical examinations, blood biochemical, family history, behavior and genetics factors were assessed.
Results
The average age was 35.44 ± 8.24 years and 51% of participants were overweight and obese. We observed men were more likely to have prevalence to T2DM and dyslipidemia (DLP) more than woman. Obese were significantly increased with prediabetes and T2DM (P < 0.001). Additionally, aging, obesity, metabolic syndrome, and DLP were associated with the development of prediabetes and T2DM. The minor T allele of the rs7903146(C/T) and rs4506565 (A/T) was associated with high risk of development of T2DM with an odds ratio of 2.74 (95% confidence interval [CI]: 0.32–23.3) and 2.71 (95% CI: 0.32–23.07), respectively; however, they were statistically insignificant (P > 0.05).
Conclusion
The SIH study's findings provide a comprehensive understanding of the health status, risk factors, and genetic factors related to T2DM in a specific working population and highlight areas for further research and intervention to address the growing burden of T2DM and NCDs.
Exploring the Relationship Between Lymphatic System Damage and Insulin Resistance in T2DM Based on Vascular Periadventitial Tensor Analysis and Triglyceride-Glucose Index
Authors: Xu Shan , Wang Xu-Yang , Yang Dong , Zhang Die , Du Li-Na , Chen Qing-Qing , Yang Yun , Lin Lin , Shen Jing , Wu Jianlin
Published: November 2023

Type 2 diabetes mellitus (T2DM) can lead to dysfunction in the brain's glymphatic system, but the relationship between glymphatic system function and insulin resistance remains unclear. The aim of this study was to investigate the connection between changes in the brain's glymphatic system function in T2DM and the surrogate marker for insulin resistance, the Triglyceride-Glucose Index (TyG). A total of 28 T2DM patients (T2DM group) and 24 healthy volunteers (HC group) were included in this study. We outlined circular regions with a diameter of 5.0 mm on diffusion tensor imaging (DTI) in the projection and association fibers in the body of the lateral ventricle. We compared the differences in DTI-ALPS index and related fiber diffusivity between the two groups. Additionally, TyG index in T2DM patients was calculated based on fasting blood glucose and triglyceride levels. Age was included as a covariate to analyze the correlation between the ALPS index and TyG index in T2DM patients. The results showed that the ALPS index and Dxproj in the T2DM group were lower than those in the HC group, while Dyproj was higher than in the HC group. In the T2DM group, the ALPS index, Dxassoc, and TyG index were all negatively correlated. The decreased ALPS index and fiber diffusivity in T2DM patients may be associated with the TyG index, suggesting a relationship between insulin resistance, lymphatic system damage, and white matter microstructure.
Increasing nurses’ occupational well-being: the role of career shocks, job crafting and supervisor autonomy support
Authors: Zhang Ying , Bu Xing , Zhang Na
Published: November 2023

Background
This study aims to explore the influence of career shocks on nurses’ occupational well-being through job crafting and the moderating role of supervisor autonomy support.
Method
The present study used a cross-sectional design. And the study included 714 frontline nurses in China, and we used structural equation modelling (SEM) to test our hypotheses.
Results
Job crafting mediated both the relationship between positive career shocks and occupational well-being and the relationship between negative career shocks and occupational well-being. Supervisor autonomy support moderated the indirect relationships.
Conclusions
Positive and negative career shocks could increase and impair nurses’ occupational well-being through job crafting, respectively. We contribute to helping nurses make sense of career shocks and preparing for career shocks, and hospital administrators and nurses’ direct supervisors can help nurse better cope with career shocks in attending job crafting activities and providing more autonomy supports.
Integration of National Health Insurance Claim Data and Animal Models Reveals Fexofenadine as a Promising Repurposed Drug for Parkinson’s Disease
Authors: Kim Jae-Bong , Kim Yujeong , Kim Soo-Jeong , Ha Tae‑Young , Kim Dong-Kyu , Kim Dong Won , So Minyoung , Kim Seung Ho , Woo Hyun Goo , Yoon Dukyong , Park Sang Myun
Published: November 2023

Background
Parkinson’s disease (PD) is a common and costly progressive neurodegenerative disease of unclear etiology. A disease-modifying approach that can directly stop or slow its progression remains a major unmet need in the treatment of PD. A clinical pharmacology-based drug repositioning strategy is a useful approach for identifying new drugs for PD.
Methods
We analyzed claims data obtained from the National Health Insurance Service (NHIS), which covers a significant portion of the South Korean population, to investigate the association between antihistamines, a class of drugs commonly used to treat allergic symptoms by blocking H1 receptors, and PD in a real-world setting. Additionally, we validated this model using various animal models of PD such as the 6-hydroxydopmaine (6-OHDA), α-synuclein preformed fibrils (PFF) injection, and Caenorhabditis elegans models. Finally, whole transcriptome data and Ingenuity Pathway Analysis (IPA) were used to elucidate drug mechanism pathways.
Results
We identified fexofenadine as the most promising candidate using National Health Insurance claims data in the real world. In several animal models, including the 6-OHDA, PFF injection, and C. elegans models, fexofenadine ameliorated PD-related pathologies. RNA-seq analysis suggested that fexofenadine is effective in PD via inhibition of peripheral immune cell infiltration into the brain.
Conclusion
This approach, which combines National Health Insurance claims data and animal model systems, provides insights into the development of novel therapeutics for PD.
Comparison of three-dimensional imaging of the nose using three different 3D- photography systems: an observational study
Authors: Ritschl Lucas M. , Classen Carolina , Kilbertus Paul , Eufinger Julia , Storck Katharina , Fichter Andreas M. , Wolff Klaus-Dietrich , Grill Florian D.
Published: November 2023

Background New 3D technologies for superficial soft tissue changes, especially in plastic and reconstructive surgical procedures, can improve the planning and documentation of facial surgeries. The purpose of this study was to compare and determine the applicability and feasibility of three different 3D-photography systems in clinical practice imaging the nose.Methods A total of 16 healthy non-operated noses were included in this prospective study. A plaster model of each nose was produced, digitized, and converted to a .stl mesh (= ground truth model). Three-dimensional images of each nose were then taken using Artec Space Spider (gold standard), Planmeca ProFace®, and the Bellus3D Dental Pro application. All resulting .stl files were aligned to the ground truth model using MeshLab software, and the root mean square error (RMSE), mean surface distance (MSD), and Hausdorff distance (HD) were calculated.Results The Artec Space Spider 3D-photography system showed significantly better results compared to the two other systems in regard to RMSE, MSD, and HD (each p < 0.001). There was no significant difference between Planmeca ProFace® and Bellus3D Dental Pro in terms of RMSE, MSD, and HD. Overall, all three camera systems showed a clinically acceptable deviation to the reference model (range: -1.23–1.57 mm).Conclusions The three evaluated 3D-photography systems were suitable for nose imaging in the clinical routine. While Artec Space Spider showed the highest accuracy, the Bellus3D Dental Pro app may be the most feasible option for everyday clinical use due to its portability, ease of use, and low cost. This study presents three different systems, allowing readers to extrapolate to other systems when planning to introduce 3D photography in the clinical routine.
Prognostics of multiple malaria episodes and nutritional status in children aged 6 to 59 months from 2013 to 2017 in Dangassa, Mali
Authors: Keita Soumba , Thiero Oumar , Toure Mahamoudou , Kane Fousseyni , Keita Moussa , Konate Drissa , Sanogo Daouda , Diawara Sory Ibrahim , Coulibaly Hamady , Thiam Sidibé M’Baye , Sogoba Nafomon , Diakite Mahamadou , Bamako Mali
Published: November 2023

Background
In Africa, the relationship between nutritional status and malaria remains complex and difficult to interpret in children. Understanding it is important in the development of malaria control strategies. This study evaluated the effect of nutritional status on the occurrence of multiple malaria episodes in children aged 6 to 59 months between 2013 and 2017 living in the village of Dangassa, Mali.
Methods
A community-based longitudinal study was conducted using cross-sectional surveys (SSCs) at the beginning (June) and end (November) of the malaria transmission season associated with passive case detection (PCD) at the Dangassa Community Health Center. Children with asymptomatic malaria infection during cross-sectional surveys were selected and their malaria episodes followed by PCD. Palustrine indicators in person-months were estimated using an ordinal-logistic model repeated on subjects during follow-up periods.
Results
The incidence rate (IR) during the period of high transmission (June to October), for 1 episode and for 2 + episodes peaked in 2013 with 65 children (IR = 95.73 per 1000 person-months) and 24 cases (IR = 35.35 per 1000 person-months), respectively. As expected, the risk of multiple episodes occurring during the period of high transmission was 3.23 compared to the period of low transmission after adjusting for other model parameters (95% CI = [2.45–4.26], p = 0.000). Children with anemia were at high risk of having multiple episodes (OR = 1.6, 95% CI [1.12–2.30], p = 0.011). However, the risk of having 2 + episodes for anemic children was higher during the period of low transmission (RR = 1.67, 95% CI [1.15–2.42], p = 0.007) compared to the period of high transmission (RR = 1.58, 95% CI [1.09–2.29], p = 0.016). The trend indicated that anemic and underweight children were significantly associated with multiple malaria episodes during the period of low transmission (p < = 0.001).
Conclusion
Our results indicate that multiple episodes of malaria are significantly related to the nutritional status (anemia and underweight) of the child during the two transmission seasons and more pronounced during the dry season (period of low transmission). Further research including other malnutrition parameters will be needed to confirm our findings.
Adalimumab as Therapy for Hidradenitis Suppurativa: a Systematic Review
Authors: Budianti Windy Keumala , Rakasiwi Muhammad Ilham Dhiya , Amin Ihya Fakhrurizal , Amelia Alda Zerlina
Published: November 2023

Background
Adalimumab (ADA) is a monoclonal antibody that is widely used as a biologic therapy for immune diseases, one of which is hidradenitis suppurativa (HS). To date, evidence-based therapeutic approaches have not been commonly used for standard of care and this is likely due to the lack of related research and the diverse therapeutic options. ADA biologic therapy shows satisfactory results and is approved by the FDA for moderate to severe HS in adult patients. Purpose: To provide an overview of the current evidence regarding the treatment of HS with ADA.
Methods
A literature search related to Hidradenitis Suppurativa Clinical Response (HiSCR) was performed on the PubMed, Scopus, and EbscoHost databases with an ADA focus on HS treatment to achieve HiSCR. Full text analysis of 8 RCT studies that met the inclusion and exclusion criteria and used a critically reviewed questionnaire from the CEBM University of Oxford.
Result
In this systematic review we obtained 8 RCTs for evaluation. The results showed that the prevalence of HiSCR after exposure to high doses of ADA, this statement was supported by 4 studies of RR > 1, meaning that the addition of ADA gave patients more opportunities to achieve HiSCR. Another finding was a decrease in Sartorius scores and DLQI after ADA treatment. ADA can reduce depressive symptoms and increase pain, this statement is supported by two studies using the PHQ and PGA-SP scores.
Conclusion
ADA has good efficacy against HS, as evidenced by the high prevalence of HiSCR and quality of life of patients.
On semi-continuity and continuity of the smallest and largest minimizing point of real convex functions with applications in probability and statistics
Authors: Ferger Dietmar
Published: November 2023

We prove that the smallest minimizer $\sigma(f)$ of a real convex function $f$ is less than or equal to a real point $x$ if and only ifthe right derivative of $f$ at $x$ is non-negative. Similarly, the largest minimizer $\tau(f)$ is greater or equal to $x$ if and only if the left derivativeof $f$ at $x$ is non-positive. From this simple result we deduce measurability and semi-continuity of the functionals $\sigma$ and $\tau$.Furthermore, if $f$ has a unique minimizing point, so that $\sigma(f)=\tau(f)$, then the functional is continuous at $f$. With these analytical preparations we canapply Continuous Mapping Theorems to obtain several Argmin theorems for convex stochastic processes. The novelty here are statements about classical distributional convergence and almost sure convergence, if the limit process does not have a unique minimum point. This is possible by replacing the natural topology on $\mathbb{R}$ with the order topologies. Another new feature is that not only sequences but more generally nets of convex stochastic processes are allowed.
Antibacterial Biocomposites: MWCNT-Coated Hanji Cellulose Paper against E. coli
Authors: Amjad Mufarah , Jeong Yunjo , Shin Subin , Kim Bogyeong , Kim Namyeon , Cho Hyunjin , Lee Sang Seok , Lee Sungbi , Na Wonjin , Jang Se Gyu , Moon SeonYoung , Lee Eun-Hee , Son Jangyup
Published: November 2023

Cellulose paper has been studied for its application as an antibacterial filter, due to its robust porous structure, minimal ecological footprint, biocompatibility, and inherent antibacterial properties. Moreover, its properties can be further enhanced via surface functionalization with metal nanoparticle (NP) agents such as silver, zinc, etc. However, the synthesis of metallic NP is challenging, costly, and environmentally harmful. On the other hand, carbon nanotubes are highly suitable as an additive to cellulose paper due to their high electrical conductivity, excellent mechanical strength, ease of fabrication, and antibacterial properties. In this study, we coated multi-walled carbon nanotubes (MWCNTs) on Hanji, a traditional Korean paper, using a simple dipping method and investigated its antibacterial activity against Escherichia coli (E. coli). The MWCNT-coated Hanji exhibited an inhibition efficiency of ~ 93% against E. coli cells. Moreover, the MWCNT coating resulted in improved mechanical strength, enhanced electrical conductivity, and increased hydrophobicity of the Hanji. Furthermore, it was observed that MWCNTs exhibited exceptionally stable adhesion to the Hanji surface. Our finding shows that MWCNT-coated Hanji could be utilized as an antibacterial material that is used as masks, air pollution filters, wallpapers in hospitals and residential complexes, and an efficient platform for antiviral studies.
Optimizing Sustainable High Performance Green Concrete Characteristics with Minimum Cement Content Using Response Surface Methodology
Authors: alani aktham , Johari Megat Azmi Megat , Majid T.A. , Bunnori N. Muhamad
Published: November 2023

In this study, an experimental design model based on the response surface method (RSM) was performed to identify the effect of optimum silica fume (SF) content on the development of compressive strength and rapid chloride permeability (RCP) of high-performance green concrete (HPGC) containing ultra-fine Palm Oil Fuel Ash (UPOFA). The UPOFA was used in ratios of (0%, 30%, and 60%) as a substitute binder for the mass of cement. SF was substituted by (0%,10, 15 and 20%) of the remaining mass of cement. The RSM with a central composite design (CCD) approach was utilized to optimize the mix design parameters. The results show that the responses (compressive strength and RCP) are influenced by the interaction of UPOFA and SF. Further, the developed models were statistically significant and exhibited a satisfactory correlation value (R2). Thus, the optimal condition was accurately predicted by the RSM method. Consequently, RSM as an optimization technique may be concluded to be a successful method for improving the mixture design. Based on this innovation, SF may expand the use of POFA in the production of green concrete with superior strength and high passive ion resistance. Meanwhile, reducing waste volume and costly power consumption for cement production.
Translation and validation of the revised “Rushton Moral Resilience Scale” in Greek
Authors: Katsiroumpa Aglaia , Moisoglou Ioannis , Konstantakopoulou Olympia , Tapaskou Theodosia , Gallos Parisis , Tsiachri Maria , Tsakalaki Anastasia , Galanis Petros
Published: November 2023

Background
High levels of moral resilience among nurses are crucial to maintain or restore moral integrity in response to moral challenges during their duties.
Aim
To translate and validate the revised “Rushton Moral Resilience Scale” (RMRS) in Greek.
Methods
We collected data from 316 nurses in Greece during July 2023. We translated the RMRS in Greek applying the forward-backward method and we adapted it in the Greek context. We used three other valid tools to estimate the concurrent validity of the RMRS: “Moral Distress Thermometer” (MDT) to measure levels of moral distress; “Quiet Quitting Scale” (QQS) to measure levels of quiet quitting; single item burnout measure to measure job burnout. We performed confirmatory factor analysis (CFA) to examine the construct validity of the RMRS.
Results
We found that the RMRS had excellent reliability since all intraclass correlation coefficients in test-rest reliability analysis were higher than 0.993 and statistically significant (p < 0.001). Moreover, Cronbach’s coefficients alpha for the response to moral adversity scale, personal integrity scale, relational integrity scale, moral efficacy scale, and total scale were 0.652, 0.795, 0.678, 0.640, and 0.778 respectively. Our confirmatory factor analysis confirmed the four-factors structure of the scale: response to moral adversity, personal integrity, relational integrity, and moral efficacy. Concurrent validity of the Greek version of the RMRS was exceptional since we found statistically significant correlations between the RMRS and MDT, QQS, and the single item burnout measure.
Conclusions
The revised “Rushton Moral Resilience Scale” is a reliable and valid tool to measure moral resilience in healthcare workers.
A review on medicinal and ethnomedicinal uses, biological features, and phytochemical constituents of Sesbania sesban L. Merr., a nitrogen-fixing plant native to the Republic of Chad
Authors: Mahamat Ousman Brahim , Younes Saoud , Otchom Boy Brahim , Franzel Steven , Hidjazi Al-Djazouli Ouchar Mahamat , Soumaya El Ismaili
Published: November 2023

This study reports on a literature review of the leguminous tree Sesbania sesban (L.) Merr, which is found in the N'Djamena region, the Republic of Chad. The study focused on S. sesban’s medicinal and ethnomedicinal uses, biological features, and phytochemical constituents to assist in future evaluations. A literature review using international academic websites, such as Science Direct, and Springer, plant databases, and data from national herbaria was conducted. S. sesban is a perennial shrub or tree that measures 3–4 meters in height. This species is becoming rare in Ndjamena but can be found in the gardens of some institutions in Ndjamena such as the Higher Institute of Educational Sciences (ISSED). The local inhabitants in Chad use the species as medicine, livestock feed, fuelwood, and for improving soil fertility and repelling desert encroachment. Traditional healers use its leaves to treat breast cancer and edema. S. sesban is an essential species native to the Republic of Chad that needs conservation and valorization. Viewing its rarity in N’Djamena today, a strategy for replanting the species in gardens, homes, and fields around Ndjamena and other regions of Chad is recommended.
Zum Wandel von Wahrnehmungsdispositionen
Authors: Röll Franz Josef
Published: November 2023

Die Relevanz und Bedeutung von Bildkommunikation vor allem in juvenilen Lebenswelten nimmt seit der Implementierung der Videoclipkultur Mitte der 1980er-Jahre permanent zu. Aktuell ist eine weitere Dynamisierung bei der Herstellung und Verwendung von Bildern vor allem im Kontext des Beziehungsmanagements und der Selbstnarration in den Sozialen Netzwerken erkennbar. Reflektiert wird, ob und welche Dispositionen bzw. Formatierungen durch die Nutzung aktueller Medien bisherige Wahrnehmungsmuster verändern bzw. modifizieren. So vermutet Katja Gunkel (2018, 39), dass die verwendeten Prinzipien der Wirklichkeitserzeugung Einfluss auf die populäre Bildsprache haben. Konkret werden die aktuellen Bildpraxen durch die Digitalisierung (Algorithmisierung), die Verwendung von mobilen Medien, die Nutzung von Mikroformaten sowie die Besonderheiten von Softwareanwendungen bzw. Internet-Plattformen (TikTok, Snapchat, Instagram) auf mögliche Beeinflussungsfaktoren reflektiert, andererseits ist der Blick darauf gerichtet, im Kontext von Alltagspraxen und deren Resonanz und/oder medienpädagogischen Impulsen, auf Potenziale bzw. Ressourcen selbstgesteuerter Aneignungsmöglichkeiten der virtuellen Lebenswelt hinzuweisen. Der Blick ist auch darauf gerichtet, ob es in der digitalen Lebenswelt visuelle Kulturen gibt bzw. geben kann, «die sich expliziten Regeln und damit auch einem algorithmischen Prozessieren entziehen» (Richter und Allert 2017, 238). Dies wird am Beispiel von zwei medienpädagogischen Projekten erörtert.
‹Auch wenn es stimmt, das hetzt letztendlich Menschen gegeneinander auf›
Authors: Brüggen Niels , Lauber Achim , Materna Georg
Published: November 2023

Bildhandeln ist zu einem wichtigen Teil des täglichen Medienhandelns von Jugendlichen geworden. Bilder werden selbst produziert, geteilt, bearbeitet und als Mittel der Kommunikation genutzt. Bilder sind jedoch für verschiedene Interpretationen offen, besonders wenn sie in digitalen Öffentlichkeiten permanent neu kontextualisiert werden. Für die Medienforschung und pädagogische Medienpraxis stellt das eine grosse Herausforderung dar. Dieser Text stellt ein Konzept der Bildaneignung zur Diskussion, mit dem die kontextspezifischen Polyvalenzen der Bildaneignung im Forschungsprozesse gefasst und für die medienpädagogische Arbeit fruchtbar gemacht werden können.
Biografisierung auf Weblogs
Authors: Kittelmann Verena
Published: November 2023

Ausgehend von den Grundlagen der Strukturalen Medienbildung und der Online-Ethnografie unternimmt Verena Kittelmann eine Analyse von bildlichen Visualisierungen und Bildpraxen im Kontext der Online-Präsenz von Veganismus. Dabei werden neben der Klärung methodischer Voraussetzungen vier Bloggerinnen empirisch untersucht, um die schriftlichen und bildanalytischen Spezifika der visuellen Inszenierung von Veganerinnen und ihrer Biografisierungsprozesse vor Augen zu führen. Der Frage, wie genau solche Prozesse von Biografisierung auf Weblogs ausgestaltet sind und wie diese grundsätzlich in ihrer medialen Komplexität und methodisch im Sinne einer medialen Strukturanalyse erschlossen werden können, geht dieser Beitrag auf verschiedenen Ebenen nach.