bluuebunny/crossref_metadata_2025 huggingface dataset:
O poder de disposição nas relações familiares e a mediação como meio de assegurar o direito à convivência familiar
Authors: Meireles Rose Melo Vencelau
Published: November 2018

O poder de disposição, entendido como exercício das situações subjetivas em geral, encontra espaço também nas relações familiares. Nesse sentido, mostra-se lícito regular autonomamente vários dos efeitos insertos na família, a exemplo da prestação alimentar, do modelo de guarda e regime de convivência dos filhos, o cuidado com idosos etc. No âmbito da convivência familiar entre pais e filhos, faz-se necessário promover comportamentos ativos daqueles que integram a família. Por vezes, a alienação parental e o abandono afetivo obstam a convivência familiar saudável, em prejuízo do interesse do menor. Nesses casos, o ordenamento dispõe de instrumentos punitivos e promocionais. A mediação constitui meio adequado para se promover o diálogo no interior das famílias a fim de se propiciar comportamentos ativos com vistas à garantir o direito à convivência familiar. A Lei nº 13.140/2015, que regula a mediação, admite que direitos disponíveis ou indisponíveis transacionáveis sejam objeto de mediação. Critério que se sugere para verificar se a matéria pode ser objeto de mediação consiste na existência de várias opções possíveis, sobre as quais os interessados podem chegar ao consenso, ainda que a homologação judicial se mostre necessária para formação de título executivo. Ademais, a finalidade precípua da mediação se relaciona à restauração do diálogo, sendo o acordo apenas eventual consequência. Nessa medida, a mediação constitui meio adequado para a promoção da convivência familiar, efetiva, saudável e sustentável.
Determination and Characterization of New Palladium Complexes and Study of their Properties
Authors: GHAMMAMY SHAHRIAR , SEDAGHAT SAJJAD
Published: November 2018

In the current study, two complexes prepared using ligands derived from hydrazine, tris [N (2, 4 di nitro phenyl) N’-(3-Nitro benzylidene) hydrazine[Pd(C13H10N5O4)]Cl2 and tris [N(2, 4 di nitro phenyl) N’-(3-phenyl alylidene) hydrazine[Pd(C15H13N4O4)]Cl2 using spectrometry techniques of UV-VIS and IR methods. In the current compounds, the way these ligands bonding with central metal investigated using IR method. Substitutions of C=N and C=O indicate that palladium being coordinated with ligands.
Design of Log Periodic Dipole Array (Lpda) with Cross-shape Eaching for Uhf-vhf Application (200-1500mhz) With Band Notch of (800mhz -1000mhz)
Authors: HEZARI MAHMOUD
Published: November 2018

Computer analysis reveals that the anomalous behavior of symmetric Log Periodic Dipole Array (LPDA)Antennahas infloenced by different parameters . The most important is mainly due to the radiation of the dipole elements in the anomalous radiating region which is excited by the transmission line resonance of the feed structure. In the design by changing the element spacing , changes of length of each element in the LPDA antenna and define cross eaching in an boom of an antenna in middle of the specified element the result is the return loss less from 200 MHZ to 1500 MHZ other than the notch between 850 MHZ 950 MHZ according to the simulation results.The log-periodical Dipole Antenna (LPDA) is a kind of ultra wide-band antennas. To achieve the purpose of miniaturization of the LPDA in radiate direction, this paper presents anunusual structure log-periodically loaded with slot cross-shape design.
Ausencia de septum pellucidum en neonato expuesto a Zika durante gestación
Authors: Rodríguez Cindy V. , Calvete Yesid Blanco
Published: November 2018

La epidemia del Zika y sus efectos a nivel neurológico, principalmente la microcefalia, han activado las alertas a nivel de Latinoamérica y Colombia debido al aumento de incidencia de estos casos; esto evidencia la necesidad de seguir los protocolos que permitan el adecuado diagnóstico materno y neonatal. A continuación, se presenta el caso de un neonato con sospecha de antecedente de exposición al virus Zika en su primer trimestre de gestación, sin anormalidades ecográficas pre natales ni déficit neurológico o microcefalia; en él, se evidenció mediante radiología la ausencia de septum pellucidum asociado a otras malformaciones a nivel cerebral mediante ecografía y TAC.
Dworkin’s Theory of Rights in the Age of Proportionality
Authors: Möller Kai
Published: November 2018

There is probably no conceptualization of rights more famous than Ronald Dworkin’s claim that they are “trumps.” This seems to stand in stark contrast to the dominant, proportionality-based strand of rights discourse, according to which rights, instead of trumping competing interests, ultimately have to be balanced against them. The goal of this article is to reconcile Dworkin’s work and proportionality and thereby make a contribution to our understanding of both. It offers a critical reconstruction of Dworkin’s theory of rights which does away with the misleading label of rights as “trumps” and shows that, far from being in conflict with proportionality, properly understood Dworkin’s work supports and supplements that doctrine and provides a much-needed account of its moral foundation as being about human dignity, freedom, and equality.
Proportionality & Comparative Constitutional Law versus Studies
Authors: Dixon Rosalind
Published: November 2018

The doctrine of proportionality has received sustained attention from comparative constitutional scholars. Yet it is an area where courts, and scholars, have made limited use of empirical or inter-disciplinary approaches to constitutional comparison. The article calls for a change in this practice as part of a broader call for greater dialogue between scholars and practitioners of conceptual and more empirical forms of constitutional comparison.
CD5 and CD43 expression are associate with poor prognosis in DLBCL patients
Authors: Huang Hui , Li Zhandong , Huang Chuansheng , Rao Jun , Xie Qin , Cui Wenhao , Tou Fangfang , Zheng Zhi
Published: November 2018

Objective

To investigate the expression and clinical significance of CD5 and CD43 in diffuse large B cell lymphoma (DLBCL) (unspecified).

Methods

Sixty - five patients with diagnosed DLBCL were enrolled. The expressions of CD5, CD43, CD10, Bcl-6 and Mun-1 were detected by immuno histochemistry. The relationship between CD5 and CD43 and clinicopathological features and prognosis of DLBCL was analyzed.

Results

In sixty - five adult DLBCL patients , 6 cases of DLBCL (9.2%) were CD5 positive, 24 cases of DLBCL (36.9%) were CD43 positive, 5 cases of DLBCL (7.7%) were both CD5 and CD43 positive. 40 cases of DLBCL (61.5%) were CD5 and CD43 negative. CD5 expression was not related to age, sex, clinical stage, type of immunophenotype (Hans typing), location, and whether infected with hepatitis B virus (HBV); CD43 expression was correlated with immunophenotyping and HBV i nfection, but was not correlated with the age, sex, clinical stage, and site. Median survival time was significantly lower in CD5- and CD43- positive DLBCL patients than CD5- and CD43-negative patien ts.

Conclusion

The prognosis of DLBCL patients may be worse with positive CD5 and CD43 expression.
Education, Human Rights, and Peace – Contributions to the Progress of Humanity
Authors: Lerman Zafra Margolin
Published: November 2018

I started my chemistry adventure while in high school, where I was the only female in a science and mathematics-oriented class. During our Junior year of high school, we were sent to the desert, close to the Red Sea in Israel to build roads. In the summers, we were in a Kibbutz on the border to help with the work needed. After work, we had time to discuss our future. Upon graduating from high school, I was drafted into the army, and in the evenings, started my college education and majored in chemistry. After finishing my term in the army, I continued my undergraduate studies in chemistry while raising my son. As I was conducting research on isotope effects, I realized that I wanted to make chemistry accessible to all. My tenet in life is that equal access to Science Education is a human right. I developed a method of teaching chemistry using art, music, dance, drama, and cultural backgrounds which attracted students at all educational levels to chemistry. I felt that as chemists, we have obligations to make the planet a better place for humankind. At this point, I became very active in working towards Scientific Freedom and Human Rights; helping chemists in the Soviet Union, China, Chile, Guatemala, and many other countries. The American Chemical Society established the Subcommittee on Scientific Freedom and Human Rights in 1986 and I chaired this committee for 26 years. At great risk to my personal safety, we succeeded in preventing executions, releasing prisoners of conscience from jail and bringing dissidents to freedom. This work led me to use chemistry as a bridge to peace in the Middle East by organizing Conferences which bring together chemists from 15 Middle East Countries with five Nobel Laureates. The Conferences allow the participants to collaborate on solutions to problems facing the Middle East and the World. The issues are; Air and Water Quality, Alternative Energy Sources, and Science Education at all Levels. Eight conferences were held and the ninth is scheduled for 2019. More than 600 Middle East scientists already participated in these conferences. Considering that most of the participants are professors or directors of science institutions who have access to thousands of students, the number of people in the network is in the thousands. Between the conferences, the cross-border collaborations are ongoing despite the grave situation in the Middle East. In these conferences, the participants succeed in overcoming the chasms of distrust and intolerance. They do not just form collaborations, but form friendships. Hopefully, we will manage to form a critical mass of scientists who will be able to start the chain reaction for peace in the Middle East. Commitment, perseverance, and many times, bravery, helped me to overcome the obstacles I encountered.
US Military Response to the Risk of Terrorist Attacks
Authors: Azam Jean-Paul , Thelen Véronique
Published: November 2018

This paper reports that the econometric findings of Azam & Thelen (2010) remain valid when the sample is extended by 10 years to cover 1990–2014 in Azam & Thelen (2018). They blame the presence of US troops in oil-exporting countries and their neighbors for increasing transnational terrorist attacks by nationals from these countries. They also confirm that foreign aid and educational capital are playing the opposite role by reducing the number of such attacks. The “Obama years” saw a lowered presence of US troops overseas and their smaller marginal impact on transnational terrorism.
Predicting Terrorism with Machine Learning: Lessons from “Predicting Terrorism: A Machine Learning Approach”
Authors: Basuchoudhary Atin , Bang James T.
Published: November 2018

This paper highlights how machine learning can help explain terrorism. We note that even though machine learning has a reputation for black box prediction, in fact, it can provide deeply nuanced explanations of terrorism. Moreover, machine learning is not sensitive to the sometimes heroic statistical assumptions necessary when parametric econometrics is applied to the study of terrorism. This increases the reliability of explanations while adding contextual nuance that captures the flavor of individualized case analysis. Nevertheless, this approach also gives us a sense of the replicability of results. We, therefore, suggest that it further expands the role of science in terrorism research.
Evaluierung der Sicherheit von Tiefbrunnen durch Ultraschallmessungen
Authors: Klieber Christoph , Brill Thilo M.
Published: November 2018

In der Öl- und Gasproduktion wird nach der Bohrung ein Stahlrohr, genannt Futterrohr, in das mehrere Kilometer tiefe Bohrloch eingeführt und der Ringraum zwischen Rohr und Gestein, genannt Annulus, mit Zement verfüllt. Die vollständige Füllung des Ringraums mit Zement bewirkt eine hydraulische Isolation der verschiedenen Produktionszonen: jegliche Flüssigkeits- oder Gasbewegung außerhalb des Futterrohres wird unterbunden, um mögliche Verschmutzung von Grundwasserschichten und Unfälle zu verhindern. Um die korrekte Füllung des Ringraums zu überprüfen, wird der Zement im Annulus nach Aushärtung in-situ durch akustische Messungen vermessen. Solche zerstörungsfreien Messungen müssen unter harschen Bedingungen (Sensortechnik und Elektronik arbeiten bei Drücken bis zu 2000 bar und Temperaturen bis zu 200°C) von der Innenseite des Futterrohres ausgeführt werden. Diese Messung soll mögliche Kanäle erkennen, die zu unerwünschten Flüssigkeits- oder Gasbewegungen außerhalb des Futterrohres führen können. Die genauesten Messungen basieren auf Ultraschalltechniken, die entweder den Abklang der natürlichen Resonanz des Futterrohres ausnutzen oder die Eigenschaften der niedrigsten symmetrischen und antisymmetrischen Schwingungsformen von Lambwellen im Futterrohr basieren. Das Gesamtvolumen aller Zementevaluierungsmessungen in der Öl- und Gasindustrie beläuft sich pro Jahr auf mehrere Milliarden Euro.
‘A Kind of Shadow’: Mirror Images and Alter Egos in Zadie Smith’s Swing Time
Authors: Quabeck Franziska
Published: November 2018

In Swing Time, her newest novel to date, Zadie Smith makes use of a first-person narrator for the first time in her career as a writer, and this change in narrative perspective is crucial to our understanding of the novel. Her narrator is slightly odd and we come to question the veracity of her account. Thus, she is ‘unreliable’ in traditional terms, but this article argues that we can equally call her inauthentic because she obviously represses feelings that are vital to the story. She does not fully expose herself, for she tries to hide the fact that she does not know who she is. Trapped between the intersectionality of race, class, and gender, oppressed by an overbearing mother and a racist society, the narrator has confined herself to an existence as a shadow. By way of Charles Taylor’s politics of recognition and Frantz Fanon’s image in the third person, this article tries to show that Swing Time’s narrator exists only as a shadow because she finds no external affirmation of herself as a black woman.
Factors Related to Healing Process of Sectio Caesarea Surgical Wound
Authors: Balla Juldin D. E. , Paun Rafael , Ludji Ina Debora Ratu
Published: November 2018

ABSTRACT

Sectio caesarea surgical wound is a disorder in the incontinence of cells due to surgery performed to remove the fetus and placenta by opening the abdominal wall for certain indications. The aim of the study was to analyze and make a modeling of the relationship of factors in healing the sectio caesarea surgical wounds. This research is an analytic observational study with cross-sectional design. The sample in this study were 42 mothers with post sectio caesarea surgery at Prof. DR. W.Z. Johannes Kupang Public Hospital. Sampling was performed by simple random sampling. Data analysis was carried out in a bivariate and multivariate analysis. The results of the bivariate analysis found that the variables that give risk to wound healing were age (p = 0.041; RP = 3.4), discharge planning (p = 0.004; RP = 4.75), personal hygiene (p = 0.003; RP = 0.18), nutritional status (p = 0.013; RP = 0.15). Multivariate analysis found three variables that consistently provide risks to wound healing, namely discharge planning (p = -2.078; RP = 829 95% CI), personal hygiene (p = -1.852; RP = 1.039 95% CI), nutritional status (p = -2,374; RP = 1,023 95% CI). Probability model for healing the surgical wound at Prof. Dr. W.Z. Johannes, namely personal hygiene, nutritional status, discharge planning are factors related to wound healing.

Keywords        :  sectio caesarea, wound, discharge planning, personal hygiene

 

ABSTRAK

Luka operasi sectio caesarea adalah gangguan dalam inkontuinitas sel akibat dari pembedahan yang dilakukan untuk mengeluarkan janin dan placenta dengan membuka dinding perut atas indikasi tertentu. Tujuan penelitian untuk menganalisis dan membuat pemodelan hubungan faktor pada penyembuhan luka operasi sectio caesarea. Penelitian ini merupakan studi observasional analitik dengan desain cross sectional. Sampel pada penelitian ini sebanyak 42 ibu post operasi sectio caesarea di RSUD Prof. DR. W.Z. Johannes Kupang. Pengambilan sampel secara simple random sampling. Analisis data dilakukan secara bivariat dan multivariat. Hasil analisis bivariat menemukan variabel yang memberikan risiko terhadap penyembuhan luka adalah umur (p=0,041; RP=3,4), discharge planning (p=0,004; RP=4,75), personal hygiene (p=0,003; RP=0,18), status gizi (p=0,013; RP=0,15). Analisis multivariat menemukan tiga variabel yang konsisten memberikan risiko terhadap penyembuhan luka yaitu discharge planning (p= -2.078; RP=829 95% CI), personal hygiene (p= -1.852; RP= 1,039 95% CI), status gizi (p= -2.374; RP=1,023 95% CI). Model probabilitas penyembuhan luka operasi di RSUD Prof. Dr. W.Z. Johannes yaitu personal hygiene, status gizi, discharge planning merupakan faktor yang berhubungan dengan  penyembuhan luka.

Kata kunci       :  sectio caesarea,  luka, discharge planning, personal hygiene
A New Hybrid Method in Global Dynamic Path Planning of Mobile Robot
Authors: Song Xiaoru , Gao Song , Chen C.B. , Cao Kai , Huang Jiaoru
Published: November 2018

Path planning and real-time obstacle avoidance is the key technologies of mobile robot intelligence. But the efficiency of the global path planning is not very high. It is not easy to avoid obstacles in real time. Aiming at these shortcomings it is proposed that a global dynamic path planning method based on improved A* algorithm and dynamic window method. At first the improved A* algorithm is put forward based on the traditional A* algorithm in the paper. Its optimized heuristic search function is designed. They can be eliminated that the redundant path points and unnecessary turning points. Simulation experiment 1 results show that the planned path length is reduced greatly. And the path transition points are less, too. And then it is focused on the global dynamic path planning of fusion improved A* Algorithm and Dynamic Window Method. The evaluation function is constructed taking into account the global optimal path. The real time dynamic path is planning. On the basis of ensuring the optimal global optimization of the planning path, it is improved that the smoothness of the planning path and the local real-time obstacle avoidance ability. The simulation experiments results show that the fusion algorithm is not only the shorter length, but also the smoother path compared the traditional path planning algorithms with the fusion algorithm in the paper. It is more fit to the dynamics of the robot control. And when a dynamic obstacle is added, the new path can be gained. The barrier can be bypass and the robot is to reach the target point. It can be guaranteed the global optimality of the path. Finally the Turtlebot mobile robot was used to experiment. The experimental results show that the global optimality of the proposed path can be guaranteed by the fusion algorithm. And the planned global path is smoother. When the random dynamic obstacle occurs in the experiment, the robot can be real-time dynamic obstacle avoidance. It can re-plan the path. It can bypass the random obstacle to reach the original target point. The outputting control parameters are more conducive to the robot’s automatic control. The fusion method is used for global dynamic path planning of mobile robots in this paper. In summary the experimental results show that the method is good efficiency and real-time performance. It has great reference value for the dynamic path planning application of mobile robot.
Lacandonia granules are present in the cell nucleus of Welwitschia mirabilis
Authors: Agredano-Moreno Lourdes-Teresa , Segura-Valdez María de Lourdes , Jiménez-Ramírez Jaime , Jiménez-García Luis-Felipe
Published: November 2018

Background: Lacandonia granules are extranucleolar ribonucleoprotein (RNPs) particles, 32 nanometers in diameter that were first described in the nucleus of Lacandonia schismatica . Cytochemical and immunocytochemical studies suggest that these particles are equivalent to perichromatin and Balbiani ring granules described in mammals and salivary glands cells of the insect Chironomus tentans, respectively. Lacandonia granules are also present in the related Triuris brevystilis , and they were later described in the gymnosperm Ginkgo biloba . These findings suggest that Lacandonia granules have a wider distribution in the plant kingdom. Species study: The plant Welwitschia mirabilis, a gymnosperm of the order Gnetales.Hyphotesis: Lacandonia granules are present in the cell nucleus of W. mirabilis . Methods: Plants were cultivated in a germination chamber and samples of leaves were processed for transmission electron microscopy. Thin sections were stained with the EDTA technique preferential for ribonucleoproteins and osmium amine specific for DNA and observed with a microscopy.Results: Light, electronic and atomic force microscopy revealed that cell nuclei of W. mirabilis display a reticulated arrangement of chromatin. Moreover, granules of 32.17 ± 1.7 nm in diameter were observed among strands of reticulated chromatin.Conclusions: Our results indicate that Lacandonia granules are present in the nuclei of the gnetal W.   mirabilis.
Reviewer ackowledgements 2018
Authors: Fragoso-Tejas Dalila
Published: November 2018

Lista de revisores de 2018
La séptima edición del diccionario académico (DRAE-1832)
Authors: Carriet Valiente Erica
Published: November 2018

El análisis de las ediciones del DRAE permite una aproximación a la historia del léxico desde la perspectiva académica y ofrece información relevante para las disciplinas de la lexicología y la lexicografía españolas. En este artículo se examinan las voces que son incorporadas por primera vez en la séptima edición del diccionario académico (DRAE- 1832). Además, se establece una clasificación de la nueva nomenclatura asentada en la edición. Con este análisis, se propone realizar un examen ceñido exclusivamente a la parte del aumento de voces y observar la repercusión de esta edición en la historia de la lexico- grafía española. Asimismo, el artículo ofrece un análisis que atiende al ámbito de la micro- estructura. En él, se examina, por un lado, la parte de la definición dentro del aumento y, por otro, los cambios que se han producido respecto a la anterior edición (DRAE-1822) a partir de una muestra cotejada.
Les glosses al Cant de Joan Antoni Almela en el quart centenari de la canonització de sant Vicent Ferrer (València, 1855)
Authors: Martí Mestre Joaquim
Published: November 2018

Existe una larga tradición en catalán de glosas explicativas a palabras consideradas obscuras o anticuadas en textos literarios antiguos. Esta tradición se remonta al siglo XVI, con la publicación de la obra de Ausiàs March, a causa del cambio de modelo de lengua literaria que se produce con el Renacimiento. Esta clase de glosas continúan durante los siglos XVII, XVIII y XIX, con una finalidad sobre todo actualizadora, para facilitar la lectura de los textos antiguos al lector moderno. El poeta valenciano del siglo XIX Joan Antoni Almela, comprometido con la restauración de la lengua literaria a partir del modelo de los clásicos, se vale también de este recurso para facilitar al lector medio de su tiempo la lectura de las voces consideradas anticuadas de su poema Cant (1855). Analizamos con detalle estas glosas, comparándolas con las fuentes que debió tener en cuenta el autor, así como con otros textos y diccionarios.
Rodríguez González, Félix (2014): Diccionario de la droga: vocabulario general y argot, Madrid, Arco/Libros, LV + 563 pp.
Authors: Jamieson Martín
Published: November 2018

Reseña de Rodríguez González, Félix (2014): Diccionario de la droga: vocabulario general y argot, Madrid, Arco/Libros, LV + 563 pp.
Some Special Dual Direction Curves
Authors: Şahiner Burak
Published: November 2018

In this paper, some special
associated dual curves called dual involute-evolute-direction curves, dual
Bertrand-direction curves, and dual Mannheim-direction curves are defined. Some
relations between dual Frenet vectors and dual curvatures of these dual
associated curves are given. Furthermore, useful methods to construct unit
speed dual slant helices from unit speed dual helices by using dual
involute-evolute-direction curves and dual Mannheim-direction curves are
presented.
Nohut Antraknozu (Ascochyta rabiei)’nun Entegre Hastalık Yönetimi
Authors: Arıcı Şerife Evrim , SEVEN Mehmet Ali
Published: November 2018

Ülkemizde nohut ekim alanlarında önemli kayıplara yol açan nohut antraknozu [Ascochyta rabiei (Pass.) Labr.]
hastalığı, koşulların uygun gittiği mevsimlerde % 100'e varan ürün kayıplarına neden
olmaktadır. Ülkemizde bu hastalığa karşı bazı fungisitler sadece tohum
ilaçlaması olarak önerilmekte olup, üreticiler tohum ilaçlamasına çok önem
vermemekte ve hastalık ile ilgili etkin bir mücadele yapılamamaktadır. Bunun
yanı sıra hastalık ile mücadelede kullanılan çeşit büyük önem taşımaktadır. Bu
çalışmada dayanıklı ve duyarlı olan Koçbaşı (duyarlı) ve Sarı 98 (toleranslı)
nohut çeşitleri kullanılarak Mancozeb, Thiram ve Boscalid + Pyraclostrobin
etken maddeli ilaçlarla farklı ilaçlama programının (tohum, yeşil aksam, tohum
+ yeşil aksam uygulamaları) Ascochyta
rabiei'ya etkisi araştırılmıştır. Çalışma sonucunda Sarı 98 çeşidi üzerinde
en uygun ilaçlama uygulamasının % 27.4 hastalık şiddeti ile tohum + yeşil aksam
ilaç uygulaması olduğu tespit edilmiştir. En etkili fungisitin ise, Sarı 98
nohut çeşidinde % 21.8 hastalık şiddeti ile Boscalid + Pyraclostrobin olduğu
belirlenmiştir. Aynı uygulamada, Koçbaşı nohut çeşidinde hastalık şiddeti %
36.3 olarak belirlenmiştir. İlaç uygulamalarının ve fungisitlerin aynı anda
değerlendirilmesi sonucu, Sarı 98 çeşitinde, Boscalid + Pyraclostrobin etken
maddeli fungisitin, hem tohumdan hem de yeşil aksamdan uygulanması neticesinde
hastalık şiddeti % 12.6 seviyesine indirdiği belirlenmiştir.
Increasing the brightness of red fluorescent proteins by saturation mutagenesis
Authors: Nguyen Erin , Pandelieva Antonia , Chica Roberto A.
Published: November 2018

Red fluorescent proteins (RFPs) are genetically-encoded fluorophores that are widely used for in vivo imaging. For all applications of RFPs, brighter variants are desired. Previously, we improved the brightness of mRojoA, a red-shifted mutant of the widely-used RFP mCherry, by designing a triple-decker motif of aromatic rings around its chromophore. This yielded the brighter variant mRojo-VHSV, which contains a triple-decker motif consisting of His and Tyr side chains that pack against the chromophore. This improved chromophore packing resulted in an approximately 3-fold brightness increase at physiological pH. However, the His side chain in the triple-decker motif of mRojo-VHSV adopted a perpendicular arrangement to the other two, which may result in a suboptimal packing arrangement. To further improve chromophore packing in mRojo-VHSV, we performed saturation mutagenesis of residues surrounding its triple-decker motif (positions 62, 97, 165, and 199). Using a microplate fluorescence screening assay, a total of 376 colonies were screened for improved brightness. The brightest mutant found, L199M, was expressed and purified, and its spectral properties were characterized in detail. We found that the quantum yield of this variant was improved by two-fold, resulting in a two-fold brightness increase compared to mRojo-VHSV as well as a 5.3-fold increase in brightness compared to mRojoA. The L199M improved variant is the basis for continued engineering with the goal of further improving the spectral properties of this family of RFPs.
Comparison of regenerative neurogenesis in response to CNS injury between adult zebrafish and mice
Authors: Chung Kuan-En
Published: November 2018

The difference between adult zebrafish and mice in their regenerative capacity following central nervous system (CNS) injury is influenced by the permissiveness of the brain microenvironment aside from the intrinsic neurogenic potential of the cell population. In adult zebrafish, glia cells largely retain their radial characteristics and neurogenic capacity, and the zebrafish brain shows full recovery after traumatic brain injury (TBI) as well as spinal cord injury (SCI). Conversely, in mice, radial glia (RG) have largely differentiated into astrocytes. Excluding certain brain regions, following TBI, reactive astrocytes that show the potential to become neural stem cells (NSCs) in vitro remain strictly non-neurogenic in vivo due to the presence of inhibitory factors in the microenvironment. Combined with prolonged inflammation and gliosis, injury to the CNS eventually results in formation of a glial scar further impeding regeneration. However in rodents, suppression of neurogenesis may be a protection mechanism against possible detrimental side-effects of neurogenesis in the long term.
Examining estradiols neuroprotective abilities and mechanisms of action in cerebrovascular accidents and neurodegenerative conditions
Authors: Uthayabalan Sukanthatulsee
Published: November 2018

Estrogens are known for playing essential roles in the body. These hormones exert crucial protective actions when faced with neural damage. Numerous studies have provided a deep understanding of these unique actions that go far beyond the scope of reproduction and reproductive regulation. Through various mechanisms, delivery routes, dosage levels, and with the age and health status of the individuals receiving the treatment in mind, the hormone can be used in protecting against neural death. This review examines the discoveries that comprise the current body of knowledge regarding estrogen as a neuro-protector against cerebrovascular accidents (CVA, stroke) and neurodegenerative diseases. These findings have great implications for improving the quality of life in the aging population. They provide insight into the impact of hormones on the protection of neural tissues, and prompt discussion between members of the scientific community, ensuring that future clinical studies utilize methods that will maximize the quality of the obtained results.
Novel hybrid biofilm system using synthetically engineered curli fibres
Authors: Ramesh Harshini , Pasumarthi Keerthana , Hou Maggie , Lee Jennifer
Published: November 2018

Hydraulic fracturing, a popular mining technique, generates heavy metal contamination in nearby freshwater aquifers. This poses a threat to both the surrounding ecosystems an  human health if exposed. Existing methods of heavy metal removal can produce additional hazardous byproducts. This proposal presents the use of a hybrid biofilm filter containing graphene and curli fibres with metal binding sites. Curli fibres are amyloid fibrils found on the extracellular biofilm of Escherichia coli (E coli.). Through the use of plasmid vectors, E. coliwill be engineered to produce secreted curli fibres with metal-binding residues. The stability and cohesive properties of the curli fibres augments the adherence to the graphene scaffolding, thus allowing for generation of a hybrid biofilm. With the filtration design and various experimental controls proposed, this model is ready for empirical proof of concept and subsequent quantitative optimization.
Laparoscopic versus open hysterectomies in obese patients
Authors: El Shakhs Soliman A. , Mohamed Moharam A. , Shahin Mahmoud A. , Eid Ahmed M.
Published: November 2018

Background: Hysterectomy is one of the most frequently performed surgical procedure. Though there are three approaches in hysterectomy (open, vaginal and laparoscopic), still there are controversies regarding the optimal route for performing it.Methods: This prospective comparative study included 42 obese patients subjected for pan-hysterectomy as a treatment. The forty-two patients were allocated into two groups: group (A) subjected to laparoscopic pan-hysterectomy, group (B) subjected to open pan-hysterectomy.Results: There was significant difference between the two groups regarding mean operative time, blood loss, analgesic requirements and hospital stay, while no significant difference regarding intra-operative complications.Conclusions: Laparoscopic hysterectomy in obese patients has emerged as a viable, safe and better alternative to open hysterectomy amongst appropriately trained surgeons.
A study on surgical intervention outcomes in chronic aorto iliac occlusion
Authors: Kumar D. Ashok , Kumar S. Vinoth
Published: November 2018

Background: Aorto-iliac occlusion is an advanced and late manifestation of the atherosclerotic vascular disease. Patients with this complicated and frequently multi-level disease can present with debilitating symptoms ranging from life-limiting claudication to limb-threatening ischemia. To study the results of Surgical management and complications of Aortic surgery in a patient with chronic, aortoiliac occlusion.Methods: Our study of 22 cases, 12 patient underwent aortic bi femoral bypass, 08 cases underwent aortobi-iliac bypass and 2 of them aortic endarterectomy. This entire patient had a 64 slice CT angiogram of aorto with bilateral lower limb and offered surgical treatment after explaining the risk and complication of surgery. All patients followed post op with the clinical examination, ABI, duplex once a month.Results: 19 patients had a patent graft at the end of the study period. The primary patency of 86%. 2 patient had graft thrombectomy, 1 patient had graft thrombectomy with extension bypass, hence the secondary patency was 95%.Conclusions: The spectrum of aortoiliac occlusive disease ranges from short, simple stenosis to long, complete occlusions, with treatment options that vary accordingly from minimally invasive endovascular procedures to major open surgical intervention.
A clinicopathological study of cheek carcinoma and different types of reconstructive procedure for its treatment in a tertiary care centre in India
Authors: Gupta Rupesh , Roy Choudhury Chandan , Gupta Sandipan
Published: November 2018

Background: The incidence of oral cancer varies globally and regionally and is closely linked with geographical, social, economical, biological, ethnic, dietary and environmental factors. In India, buccal mucosa (cheek) is the most common site for the lesion having 50% of all the oral cavity cancers and the incidence of oral cancers is about 10.6 % of all cancers. The aim of the study was to study the mucosal lesions with regard to mode of presentation, aetiopathology, histopathological aspects, various surgical modalities.Methods: The prospective observational and descriptive tertiary care institute based case study was undertaken at Medical College, Kolkata. A total of 30 patients were included in the study.Results: Maximum number of patients was in the 51-60 yr age group and the male: female sex ratio was 7:3. The maximum risk factors were found to be smoking and tobacco. 16.67% patients had premalignant lesions namely leucoplakia whereas 73.33% of the patients presented with oral ulcers as the chief complaint. Most of the patients presented in the late stage. Squamous cell carcinoma was the most common histological type. Out of 30 patients, 6 underwent wide local excision only and the rest underwent neck dissection. Mandibulectomy was done in 14 patients, Pectoralis major myocutaneous flap was the most common reconstructive procedure used (43.33%).Conclusions: Cancer of the oral cavity accounts for a high incidence in our country due to our social habits. In spite of easy accessibility to early lesion, the number of locally advanced lesion is very high. This can be prevented by creating health awareness.
Angry young man syndrome: anger based dominant hand injuries
Authors: Hongaiah Deepak , Sathanantham Dinesh Kumar , Sanganbhonia Spurthi
Published: November 2018

Background: The incidence of self-inflicted anger related upper extremity injuries due to punching glass, involving dominant hand has increased in recent years even in our rural population of less than 1.5 million in District of Kolar, Karnataka, India. Although hospital stay is short, these patients require long term follow up, physiotherapy and occupational rehabilitation.Methods: This study is a case series involving a a retrospective analysis from June 1, 2015, to July 31, 2017.  Our study involved only glass cut injury following an angry intention.Results: This study included 9 eligible patients who were all young male aged between 18 to 28 years (median age: 23.4 years) who had triggering factor before punching the glass pane. All patients had tendon injuries, flexors (n=4), extensor (n=3), both (n=2), muscle injuries (n=1), median nerve (n=2), radial artery (n=3). All injuries required operative intervention. Mean hospital stay was 5.2 days. Mean rehabilitation period was 5.2 months.Conclusions: These types of injuries can be prevented by regular counseling for stress/anger management as a part of rehabilitation to prevent further recurrences.
Tumescent non-tumescent technique for split thickness skin graft harvesting
Authors: Rajendran M. K.
Published: November 2018

Background: Split-thickness skin graft failures can be attributed to flaws in the recipient bed which has to be well prepared. Tissues with limited blood supply such as bone, tendons, cartilage or sites with necrotic tissue or infection do not accept skin grafts. Adrenaline is used to harvest skin grafts due to its vasoconstriction effect which limits blood loss. The aim of our study was to determine skin graft take after tumescent technique compared to a non-tumescent technique for harvesting.Methods: Two treatment groups of patients who fulfilled the inclusion criteria were randomly assigned. Forty patients underwent split-thickness skin graft harvesting with tumescent technique and forty patients underwent non-tumescent split-thickness skin graft harvesting. The recipient site was opened in both groups on the fifth day after surgery and take rate assessed. The donor site was assessed on day ten and if not healed, followed up for three weeks.Results: There was a statistically significant association between skin graft take rate and skin grafting technique (p=0.011). The mean graft take rate was 2.5% higher in the tumescent group compared to the non-tumescent group (96.3% compared to 94%). On day 10, there was no difference in percentage healing of donor sites between the tumescent and non-tumescent groups, p=0.562.Conclusions: Tumescent technique significantly reduced intraoperative blood loss. It is safe, inexpensive and easy to use. The subdermal adrenaline/saline injection creates a smooth, dense surface which assists debridement and donor harvesting.
Efficacy of chemical sphincterotomy with 2% diltiazem cream vs. surgical sphincterotomy in the management of chronic fissure in ano: a clinical study
Authors: Kenche Jeevan , Reddy Chandrashekhar
Published: November 2018

Background: Surgical intervention like lateral internal sphincterotomy is very effective and in a time of few weeks, healing can occur but there is danger of the anal incontinence. Hence alternative methods were sought like 2% diltiazem and other agents and they have been shown to lead to proper healing without anal incontinence. The objective was to study efficacy of chemical sphincterotomy with 2% diltiazem cream vs. surgical sphincterotomy in the management of chronic fissure in ano.Methods: A hospital based follow up study was carried out among 60 patients with chronic fissure in ano. They were randomly assigned in two groups. Group I consisted 30 patients who were treated with 2% diltiazem cream on outpatient basis. Group II patients i.e. 30 patients were operated for sphincterotomy. Both the group patients were followed for six weeks at two weeks interval. Outcome like complete healing, fecal incontinence, flatus incontinence was seen at follow up. Chi square test and t test were used to determine the significant difference between the groups.Results: Both the groups were comparable to each other in terms of age, sex, presenting symptoms, mean duration of symptoms and internal findings. Diltiazem group patients had significantly much better healing rate i.e. 96.7% compared to only 80% from patients with   surgery group. Incidence of complications like fecal/flatus incontinence was zero in diltiazem group compared to 13.3%/20% in surgery group.Conclusions: Authors conclude that diltiazem 2% topical application is better than surgical sphincterotomy and should be used instead of surgery.
Angiodysplasia of left colon extending to anal verge landed patient into APR: a rare finding
Authors: Jain Amit , Jain Divya
Published: November 2018

Angiodysplasias is a kind of vascular malformation preferably involves the veins. Angiodysplasia of colon is the second most common cause of lower gastrointestinal bleeding after diverticulosis. It usually involves caecum and ascending colon. Patient may either present with complaints of fresh bleeding per rectum or with melena. It usually occurs in elderly because of age related degeneration of small blood vessel walls. The case presented here involves a male patient of 25-year age with complains of intermittent bleeding per rectum and generalized weakness from one month. After examination it was found to have vascular ectasia involving mid transverse colon, left colon and the rectum coming down to anal verge which culminated into abdominoperineal resection. Biopsy of resected segment came to be angiodysplasia with external surface of specimen showing dilation of multiple vascular channels in entire length up to anal verge. This case report shows that though angiodysplasia is more common in old age but while exploring a young patient with lower gastrointestinal tract bleeding, and congestive changes are found in left colon possibility of angiodysplasia should also be kept in mind.
Anterior abdominal wall myxoid liposarcoma: a rare presentation
Authors: . Parikshith , R. K. Ashwini , Khadri Syed Iqballula Sha , S. Rajagopalan
Published: November 2018

Liposarcoma is the most common type of soft tissue sarcoma, a mesenchymal malignancy. The extremities are the most common site followed by the retroperitoneum for liposarcomas. There are 5 histologic types of liposarcoma, as follows: well differentiated; myxoid; round cell; pleomorphic; and dedifferentiated. As very few cases of MLS have been reported, we report a rare case of an MLS of a 72-year-old male who presented with spherical mass in the abdomen wall. Computed tomography (CT) found a tumor in abdominal wall extending with both intra and extra abdominal components. There were no other abnormal symptoms and the laboratory testing was also unusual. The tumor was successfully excised, which was diagnosed MLSs in pathology. Following standard principles, after complete excision, the patient was referred to a higher center for radiotherapy. The patient was followed up for 6 month and no disease recurrence was identified. MLSs are rarely seen in health centers, irrespective of the presenting signs or histologic features.
Síndrome de Mauriac: reporte de un caso
Authors: Pérez Laínez Sergio Eduardo , Rueda Ochoa Hugo , Simental Mendía Luis
Published: November 2018

INTRODUCCIÓN: El síndrome de Mauriac es poco frecuente; se caracteriza por retardo del crecimiento, hepatomegalia y obesidad en niños con diabetes mellitus tipo 1.CASO CLÍNICO: Niña de 11 años, 4 meses, con diabetes mellitus tipo 1 de 8 años de evolución, tratada con insulina glargina y ultrarrápida. Los padres refieren aumento de volumen abdominal gradual de aproximadamente 3 meses de evolución y mal control glucémico en los últimos 12 meses. Fue llevada al hospital por un cuadro clínico de 17 horas de evolución, caracterizado por polidipsia y poliuria. En la exploración física se encontraron: retardo del crecimiento, retraso en la maduración puberal y hepatomegalia. Los marcadores de hepatitis viral (virus de hepatitis A, B, C, D, Epstein-Barr, citomegalovirus y toxoplasma) o autoinmunitaria (anti-ADN) se reportaron negativos. La biopsia hepática reveló abundante depósito de glucógeno.CONCLUSIÓN: Si bien el síndrome de Mauriac es raro debe sospecharse en pacientes con diabetes mellitus tipo 1 no controlada, con la finalidad de establecer un diagnóstico y tratamiento oportuno.PALABRAS CLAVE: Síndrome de Mauriac; hepatomegalia; obesidad; diabetes tipo 1; insulina glargina; hepatitis auntoinmune; hiperglucemia.
Recount Text in SFL Perspective: Pedagogical Implication based on Student’s Writing Analysis
Authors: Cakrawati Laxmi Mustika
Published: November 2018

AbstractRecount can be considered as one of the easiest types of text that can be written by students. This might be the reason why the text is learned in both junior and senior high school level. However, there are still a lot of students who cannot produce the text well. This study was aimed to analyze student’s recount text based on three metafunctions in SFL perspective. It is expected that by identifying students’ problems, teachers can decide and design appropriate pedagogical plan. The result of the study reveals that the student’s major problems in producing recount text are the use of subject and verb tense (interpersonal metafunctions), the generic structure of the text, the use of conjunctions, the grammatical errors, and L1 interference. Therefore, considering the problems found in the student’s recount text, POWER strategy is proposed as one of strategies can be applied by teachers in teaching writing, particularly teaching recount text. Keywords: recount text, systemic functional linguistics, metafunction, POWER strategy
Актуальные проблемы реализации концепции импортозамещения в сельском хозяйстве (на примере рынка сои)
Authors: Линников Павел Иванович
Published: November 2018

Перечень вопросов продовольственной безопасности страны с каждым годом увеличивается новыми пунктами. Решение задачи обеспечения населения пищевой продукцией с высоким содержанием белка особенно актуализировалось на фоне санкционной политики и реализации концепции импортозамещения. Одним из направлений ее эффективного решения является увеличение масштабов производства сои и продуктов ее переработки. Целью написания статьи является проработка комплекса проблем, сдерживающих наращивание объемов производства сои отечественным сельским хозяйством, а также поиска направлений их купирования. В работе анализируется динамика мирового рынка сои, а также возможности российских производителей нарастить объемы производства, как для внутреннего потребления, так и для экспорта в условиях обостряющейся мировой конкуренции. В достижении поставленной цели, исследуются аспекты, связанные с динамикой развития мирового рынка сои с учетом показателей посевных площадей, урожайности, цены и возможностей наращивания объемов производства. Раскрываются закономерности развития отечественного рынка сои в рамках концепции импортзамещения при решении задач продовольственной безопасности. Предлагается рассматривать результативным вариантом развития растениеводческого бизнеса симбиоз интересов государства, регионов и частного бизнеса по наращиванию объемов производства сои. В качестве вывода делается предложение о необходимости реализации стратегических концепций с учетом результатов исследования структуры и взаимосвязей возникающих хозяйственных отношений в отрасли, складывающихся между участниками производственного процесса и рынка.