bluuebunny/crossref_metadata_2025 huggingface dataset:
Stress among nurses and associated factors during the COVID-19 pandemic in Hanoi, Vietnam, in 2022
Authors:   Hanoi University of Public Health, Tran Thi Thu Thuy , Nguyen Hong Diep Anh ,   Hanoi University of Public Health, Nguyen Van Bang ,   108 Military Central Hospital, Nguyen Thi Viet Nga ,   Saint Paul General Hospital, Nguyen Thanh Binh ,   Saint Paul General Hospital, Nguyen Duc Long ,   Saint Paul General Hospital, Nguyen Thuy Quynh ,   Hanoi University of Public Health, Nguyen Thanh Huong ,   Hanoi University of Public Health
Published: January 2024

Objective: To describe the stress prevalence and associated factors among clinical nurses at Saint Paul General Hospital in Hanoi during the COVID-19 epidemic in 2022. Methods: This study applied a cross-sectional study design and was a baseline of an original randomized controlled trial. Data of 400 Saint Paul General Hospital nurses were collected from March 2022 to April 2022 in Hanoi. Self-reported questionnaires included the stress component of the 21-item Depression, Anxiety and Stress Scale (DASS-21) and several demographic and work-related variables. Bivariate and multivariate logistic regression was performed to identify factors associated with nurses’ stress using SPSS 20.0. Results: The prevalence of stress in Saint Paul General Hospital nursing staff was 11.8%. The mean stress score was 7.8 (SD=6.3). Multivariate logistic analysis showed that anxiety and depression were significantly associated with the increased risk of stress among nurses (OR=6.6, 95% CI = 2.3-19.1 and OR=12.5, 95% CI = 5.3-29.5, respectively). Conclusion: Stress was observed among nurses. Its association with anxiety and depression calling for hospital management to consider mental health interventions such as stress management for all nurses to improve their well-beings and quality of services. Keywords: Associated factors, COVID-19, nurse, stress, Vietnam.
Stress situation and associated factors among nursre in clinical departments at Sa Dec General Hospital, Dong Thap province, in 2021
Authors:   Hanoi University of Public Health, Nguyen Thuy Quynh , Pham Thi Ngoc Lai ,   Dong Thap Rehabilitation Hospital, Ta Quynh Chi ,   Hanoi University of Public Health
Published: January 2024

Objectives: Nursing is an occupation that has high levels of stress. This study was to find out the degree of work-related stress among nurses and some associated factors at Sa Dec General Hospital, Dong Thap province in 2021. Methods: This cross-sectional survey design study was conducted with the participation of 200 nurses in clinical departments of the Sa Dec General Hospital, Dong Thap province, in 2021. Results: 29% of nurses had stress. Divided by four levels of stress, 17.0% nurses had mild stress, 7.0% had moderate stress, 3.0% had severe stress and 2.0% had extremely severe stress. Some factors of job characteristics were associated to the stress’s nurses: work overload; high intensity workplace; a large number of patients requiring care per day; witnessing the patient’dead dying and pain. Working environment factors were associated with increased stress of nurses: facilities and work equipment; cramped space; working in a noisy workplace; working in conditions of extreme heat; being disrespected, no opportunities for further professional learning. Conclusions: The hospital need to ensure a suitable workload for nurses and to avoid exceeding the capacity of the nurse. Workplace condition in hospital should be improve. Keywords: Nursing, clinical department, hospital, mental health, stress.
Compliance with National guidelines for antibiotic prophylaxis use in surgery: A case study in Thu Duc City Hospital, South of Vietnam
Authors:   Hanoi University of Public Health, Hua Thanh Thuy , Le Duc Dung ,   Thu Duc City General Hospital, Chu Quoc Thinh ,   Drug Administration of Vietnam
Published: January 2024

Objectives: To evaluate compliance with national guidelines for surgical antibiotic prophylaxis use (SAP) at a general hospital in southern Vietnam and explore the impact of patient and surgery demographics on compliance. Methods: A cross-sectional study using quantitative methods was used. A total of 270 medical records (MRs) of patients who underwent clean or clean-contaminated surgeries between January 1, 2021, and June 30, 2021, at Thu Duc City Hospital were selected by systematic random sampling. A range of data was collected, which included patient demographics, surgery type, and antibiotic selection, as well as appropriate timing, route of administration, and duration of prophylaxis for each surgical procedure. Evaluating compliance based on the national practice standards for SAP. Data were entered by Epidata 3.0 and analyzed by SPSS 22.0 software. Results: Of the 270 cases included in the study, the overall compliance rate of SAP use was only 17.0%. Inadequate timing of SAP administration (17.8%) was the major cause of non-compliance, follow by inappropriate antibiotic selection (77.0%). Furthermore, patient and surgery characteristics were found to play a significant role in compliance with guidelines, with gender, surgery type, wound infection condition, and pre-operative hospital stay all having notable correlations. Conclusion: In conclusion, the overall compliance rate of SAP use was lower than expected, and there was a significant difference among specific types of surgeries. There is a relationship between surgery type, wound infection classification, and length of pre-operative hospital stay with SAP use compliance (p < .01). To improve compliance with national guidelines for SAP use, appropriate timing, and antibiotic selection should be emphasized. Further efforts are still needed to improve the standards of antiseptic surgery in Vietnam. Keywords: Compliance, adherence, antibiotic prophylaxis, surgery, hospital.
Drinking water quality and associated factors at water supply stations in Quang Ngai Province in 2022
Authors:   Quang Ngai Provincial Center for Disease Control, Tran Thi Kim Tai , Tran Thi Tuyet Hanh ,   Hanoi University of Public Health
Published: January 2024

Objectives: This paper aims to describe drinking water quality at water supply stations in Quang Ngai province according to Vietnam Standards (QCVN 01-1:2018/BYT) and to identify some associated factors affecting water quality. Methods: The study used test results of 41 centralized water supply stations collected from Quang Ngai Center for Disease Control in December 2022 and compared them with QCVN 01-1:2018/BYT. Results: 58.5% of stations had water quality that met QCVN 01-1:2018/BYT; 65.9% and 80.5% of stations with physicochemical and microbiological parameters met the standards. The parameters not meeting the standards were mainly nitrate content, hardness, chloride, taste, residual chlorine, Coliform and E. coli. In particular, 34.1% of stations did not meet the standard for the nitrate parameter. Private enterprises had the highest rate of meeting the standard (85.7%), followed by state enterprises (79.0%), private stations (25.0%) and cooperatives (14.3%). The Chi-square test showed that water supply stations had water quality checked, applied the right prices, trained operators in water supply, had a system of settling, filtering, disinfecting, and cleaning facilities and stations with operating time within five years had better water quality. Conclusion: Water supply facilities, especially private stations and cooperatives need to improve their management, comply with regulations on internal inspection and pay attention to treating nitrate contamination. There should be a plan to send operators to specialized training in water supply. It is necessary to invest in the construction of a treatment and disinfection system, to replace the degraded, leaking distribution pipeline and to make an annual plan for the maintenance and cleaning of water supply facilities. The authorities need to provide specialized training on water supply and guide the management regulations for facility owners and operators. At the same time, there should be sanctions and strict handling measures for domestic water supply stations that violate regulations.
Association between retinol intake and risk of gastric cancer: a case-control study in a Korean population
Authors:   Hanoi University of Public Health, Bui Quynh Anh , Madhawa Gunathilake ,   Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-si, Gyeonggi-do, South Korea, Lee Jeonghee ,   Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-si, Gyeonggi-do, South Korea, Choi Il Ju ,   Center for Gastric Cancer, National Cancer Center Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, South Korea, Kim Young-Il ,   Center for Gastric Cancer, National Cancer Center Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, South Korea, Jeongseon Kim ,   Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-si, Gyeonggi-do, South Korea
Published: January 2024

Objectives: Gastric cancer has the fifth highest incidence among cancers in the world and is the most common cancer in South Korea. Several studies suggested a protective role of retinol in oesophageal, liver, lung, and breast cancer, while this effect was still inconsistent in gastric cancer. Methods: We conducted a case-control study that included 415 cases and 830 controls at the National Cancer Center Hospital in Korea. Dietary information of the participants was collected using a validated semi-quantitative food frequency questionnaire (SQFFQ) covering 106 food items. A multivariate logistic regression model was performed to investigate the association between retinol intake and risk of gastric cancer. Results: The highest consumption of retinol intake was significantly associated with lower odds of gastric cancer in the total subjects (odds ratio (OR)=0.58, 95% confidence interval (CI)=0.37–0.89), and among women (OR = 0.43, 95% CI = 0.21–0.89), but not among men (OR = 0.72, 95% CI = 0.41–1.26). After stratifying by Helicobacter pylori (H. pylori) infection, we identified a reduced risk of gastric cancer when consuming the highest level of retinol intake only among H. pylori-positive patients. This trend was demonstrated in the subgroups of current drinkers and those who had not smoked without adjustment for H. pylori infection. Conclusion: Retinol intake was proved as a protective factor against gastric cancer, and this effect remained among women and patients with H. pylori infection even after adjustment for multivariable.
Respiratory function of workers at some wood factories in Bac Tu Liem district, 2022
Authors:   Hanoi University of Public Health, Vu Thai Son , Nguyen Thi Huong ,   Hanoi University of Public Health
Published: January 2024

Objectives: This study aimed to assess the respiratory function status and associated factors among workers in wood factories in Bac Tu Liem district. Methods: A total of 80 workers from six woodworking establishments participated in this cross-sectional study. Respiratory symptom questionnaires based on ECCS-87 and ATS-DLD-78a were used to collect data on symptoms experienced within the past 12 months. Respiratory function measurements were also conducted during breaks and at the end of shifts. Results: Workers with 3-5 years of experience accounted for 63.8% of the total sample. The majority (92.5%) were exposed to harmful workplace factors for more than 8 hours per day. Only 13.8% reported using full personal protective equipment. Concentrations of respiratory particles and Total Suspended Particulate (TSP) in wood facilities exceeded allowable standards. Cough was the most commonly reported respiratory symptom, with a prevalence of 28.8%. Approximately 66.3% of subjects had normal respiratory function, while restrictive ventilation disorder accounted for the highest proportion of respiratory disorders at 21.3%. Statistical analysis revealed significant associations between respiratory dysfunction and work experience (OR=2.56, p<0.01), duration of exposure to hazardous factors (OR=1.8, p<0.05), use of personal protective equipment (OR=7.12, p<0.05), and the occurrence of respiratory symptoms (OR=1.73, p<0.01). Conclusions: workers in furniture manufacturing facilities in Bac Tu Liem district face exposure to high concentrations of total particles, respiratory particles, and toxic gases that surpass permissible standards. The study also found a significant relationship between respiratory dysfunction and employee characteristics. Keywords: Respiratory function, wood workers, wood factories.
How KoboToolbox versus Unipark platform are selected in data survey to detect child maltreatment in Vietnam: A discussion paper
Authors:   Hanoi University of Public Health, Le Minh Thi , Nguyen Tho ,   International Research Institute for Artificial Intelligence and Data Science, Dong A University, Da Nang, Vietnam, Nguyen Minh Anh ,   Tufts University, USA, Dinh Thu Ha ,   Hanoi University of Public Health, Nguyen Thai Quynh Chi ,   Hanoi University of Public Health, Nguyen Thanh Huong ,   Hanoi University of Public Health, Vu Thi Thanh Mai ,   Hanoi University of Public Health, Nguyen Thi Phuong ,   Hanoi University of Public Health, Bui Thi Phuong ,   Hanoi University of Public Health
Published: January 2024

Background: Due to the importance of good data collection and management in research, studies increasingly rely on digital tools to make this process more efficient and error-free. For the topic on child maltreatment in Vietnam, we considered the Unipark and KoboToolbox to conduct our questionnaire and collect, manage, and visualize our data. This discussion paper is about which KoboToolbox or Unipark tools are better for data survey of child maltreatment studies in Vietnam. Methods: We conducted three phases: document review, experts experimented with functions, lean operation, skip logic questions of tool and validation criteria to limit errors in filling by respondents and a pilot survey was conducted by 242 students at a secondary school in Bac Giang province. Results: Through three phases in comparison with Unipark, KoboToolbox dominates. KoboToolbox is convenient and time-saving in constructing a complex questionnaire with more than four hundred questions and skips logic by Excel software and free fee. It has a validation criteria function to mitigate data bias due to filling and clustering related questions in each part, creating a friendly user interface for experts’ experience and students. Kobo toolbox’s offline data collection platform capability addressed challenges related to unstable internet connectivity in local contexts. Conclusions: Kobotoolbox was chosen and employed for optimizing constructing questionnaires, data collection efficiency, and quality, ultimately contributing to a more comprehensive understanding of child maltreatment in Vietnam. Keywords: KoboToolbox, Unipark, platform, software, child maltreatment, data collection, data management.
Preventive Measures Against Monkeypox: A Scoping Review
Authors:   Hanoi Medical University, Phan Thanh Hai , La Que Lam ,   Hanoi Medical University, Le Viet Lam ,   Hanoi Medical University, Duong Van Vuong ,   Hanoi Medical University, Nguyen Ngoc Minh Anh ,   Hanoi Medical University
Published: January 2024

Objectives: Monkeypox (MPX), a viral zoonotic disease, is causing current outbreaks with a rise in cases. This study aims to describe available monkeypox preventive measures and summarize their results. Methods: We conducted a scoping review on monkeypox prevention methods. A search strategy including keywords of (1) monkeypox and (2) prevention was performed on PubMed, Scopus, and Embase. Results: Out of 2198 retrieved articles, 1046 duplicates were removed. After title, abstract, and full-text examination, 8 eligible studies on specific preventive measures were included. The most common monkeypox prevention methods were vaccination and health communication. Smallpox vaccines are effective, but immunity may decline over time. Film-based educational activities were successful in enhancing understanding and promoting healthy behaviors, while media campaigns had little impact. Conclusions: Monkeypox has limited data on prevention methods for humans. Future research on the effectiveness of these vaccines in humans, the relationship between vaccine efficacy and time since immunization, and the requirement to more thoroughly evaluate the impact of media campaigns are essential. Keywords: Monkeypox, Prevention, Vaccination, Health communication
Knowledge and attitudes toward using prenatal screening tests of first-trimester pregnant women in North Tu Liem District in 2022
Authors:   Hanoi University of Public Health, Nguyen Duc Trung , Pham Thuy Ngan ,   Hanoi University of Public Health, Phung Thi Thuy Tien ,   Hanoi University of Public Health, Tran Xuan Thang ,   Hanoi University of Public Health, Bui Thi Ngoc Ha ,   Hanoi University of Public Health
Published: January 2024

Objective: Describe knowledge, attitudes and related factors as well as the readiness regarding opting prenatal screening tests of first-trimester pregnant women in North Tu Liem District, Hanoi in 2022. Analyzing some factors affect knowledge and attitudes toward the use of prenatal screening tests. Methods: A quantitative, cross-sectional study was applied, using a 5-point Likert scale to assess. SPSS20 software was used to analyzed the answers of 150 participants. Main findings: The mean score of knowledge and attitudes ranged from 3,47 – 3,69 and 3,34 – 3,57 respectively on a 5-point Likert scale. In addition, Ultrasound was the most well-known test (100% women knew about it) and they mainly accessed prenatal screening’s information through Obstetricians (119/150 options). Notably, educational level, employment status and place of residence significantly affected knowledge and attitudes toward opting prenatal screening tests while the number of children was unrelated. Conclusions: First-trimester pregnant women in North Tu Liem District, Hanoi had a good level of knowledge and relatively positive attitudes toward the use of prenatal screening tests. Pregnant women with a high level of education, having an occupation and living in the urban areas have better knowledge and attitudes toward using prenatal screening tests. Keywords: Assessment, knowledge, attitudes, pregnant women, prenatal screening tests, first-trimester, North Tu Liem.
The Number of dengue hemorrhagic fever cases in Pleiku city, Gia Lai province in the period 2012 - 2021: Current status and correlation with weather factors
Authors:   Center for Disease Prevention and Control of Gia Lai Province, Phan Vu Ho , La Ngoc Quang ,   Hanoi University of Public Health, Pham Quang Thai ,   National Institute of Hygiene and Epidemiology, Truong Thi Kieu Giang ,   Gia Lai Department of Health, Vu Thi Hau ,   Hanoi University of Public Health
Published: January 2024

The study was conducted to understand the current status of dengue hemorrhagic fever cases and some related weather factors in Pleiku city, Gia Lai province in the period of 2012 - 2021. A cross-sectional study was conducted by using secondary data on all reports on the number of dengue fever cases and vector indicators and of the hydro-meteorological station of the Central Highlands region, monthly average indicators of weather in Pleiku city, Gia Lai province from August 2021 to September 2022. From 2012 to 2021, Pleiku city had 10,031 cases of dengue hemorrhagic fever with an overall incidence rate of 347.48/100,000 people, a higher rate of dengue fever than some other provinces. The incidence of Dengue Hemorrhagic Fever is not uniform from year to year, it is cyclical in 3 years and according to the rainy season. Minimum temperature, humidity, and rainfall by month/season correlate positively with incidence From the results, it is recommended to increase monitoring, control, and detection of outbreaks in places with high population density from the time preparing for the rainy season - May every year. It is necessary to raise people's awareness about disease prevention, improve their status and equip them with knowledge to prevent mosquito bites, especially those over 15 years old who need to be equipped with protective clothing to avoid mosquito bites when working. Keywords: Dengue hemorrhagic fever, weather factors, Gia Lai province
Working motivation of nurses and some influencing factors at Van Ninh District Medical Center, Khanh Hoa Province in 2023
Authors:   Medical Center in Van Ninh district, Khanh Hoa province, Đỗ Thị Diệp Qua , Nguyen Duc Thanh ,   Hanoi University of Public Health
Published: January 2024

Objective: Describe and analyze some factors affecting the working motivation of nurses at the Medical Center of Van Ninh district, Khanh Hoa province in 2023. Methods: Cross-sectional study, quantitative combined with qualitative. Quantitative data were collected through interviews with 86 nurses. Qualitative data were collected through 09 in-depth interviews and 01 group discussion with representatives of leaders and representatives of faculties/departments. Results: The percentage of nurses who are motivated to work together is 70.9%. Percentage of motivated nurses with conscientiousness factor, job satisfaction factor, and organizational commitment factor are: 86%; 76.7%; 75.6%. Factors that positively affect the staff of the nurse: increased income, good relationship between colleagues, nature of work, career advancement, recognition of achievements, good management policy. Factors that both negatively affect work motivation: Salary, working conditions, professional training, relationship between leaders and employees. Recommendations: Medical centers need to pay special attention to the issue of salary on time, improve facilities, create opportunities to improve the professional qualifications of nurses. Keywords: Working motivation, nursing, influencing factors, Van Ninh Medical Center
Epidemiology of thalassemia among some ethnic minorities of Lao Cai Province in 2018
Authors:   Department of Health of Lao Cai Province, Duong Thai Hiep , Nguyen Duc Diep ,   Lao Cai Province General Hospital
Published: January 2024

Objective: to estimate the prevalence of various form of Thalassemia gene carriers and the rate of thalassemia gene mutations among some ethnic minorities of Lao Cai Province in 2018. Methods: A cross-sectional study was conducted to obtain information and blood specimens from 1433 subjects from ethnic minority groups include Phu La, Nung, Bo Y, Giay and Ha Nhi in Lao Cai province from April 2017 to September 2018. Results: The prevalence of people carried the thalassemia gene was relatively high, about 24.5%. the rate of carrying α thalassemia gene was 15.2%; the rate of carrying β thalassemia gene was 11.4%; the rate of carrying both α and β thalassemia genes was 2.1%. The Giay and Nung ethnic groups have the highest rates of thalassemia carrier. There are 10 types of gene mutations detected, in which the most common α thalassemia gene mutation was --α3.7/αα; --α4.2/αα (6.8%) and the most common β thalassemia gene mutation was Cd17/17 (7%). Conclusion: The rate of common thalassemia gene carrier for 5 ethnic groups is high, of which Giay and Nung have the highest rate. Therefore, it is necessary to promote screening and detection of gene carriers while improving the quality, diagnosis and treatment of thalassemia in the area. Keywords: Thalasemia gene, Thalassemia, ethnic minorities
Impacts of the district "bypass" policy on health insurance examination
Authors:   Hanoi University of Public Health, Nguyen Thi Thuy Nga , Nguyen Lan Huong ,   Vietnam Social Security, Nguyen Thi Kim Lien ,   Vietnam Social Security
Published: January 2024

The Law on Health Insurance expands the right to choose a place of medical examination and treatment for participants of Health Insurance (HI) through the policy of bypassing the district from January 1, 2016. The study was carried out with the objective of describing the impact of the policy of “bypass” under the provisions of the Law on Health Insurance on the use of the health insurance fund. The study analyzed available data from the claim review information system managed by the social insurance agency from 2014 to 2021. The research results show that the policy of “bypass” at the district level has the following impacts: 1) Increased the number and cost of health care services at the district level, while decreased at the commune level; 2) Private health facilities degraded to class III and at the same time have other forms of promotion to attract patients and increase revenue); some patients went for medical examination and treatment many times; 3) The design of capitation payment had to be adjusted to be consistent with the regulation of "Bypass" which is the allocation of fixed funds according to the number of visits at the health facility. The district's "Bypass" policy makes it easier for people to access health services but may affect the efficiency of using the health insurance fund.
Treatment adherence in hypertensive patients managed and treated at health stations in Hoa Vang district, Da Nang city, in 2023 and some related factors
Authors:   Hanoi University of Public Health, Nguyen Thi Anh Tho , Nguyen Duc Hoa ,   Vietnam Social Insurance, Bui Thi Tu Quyen ,   Hanoi University of Public Health
Published: January 2024

Objectives: To describe the treatment adherence among hypertensive patients and to determine some related factors to treatment adherence. Research methods: An analytical cross-sectional study was carried out on 360 hypertensive patients being managed and treated at health stations in Hoa Vang district. Result: The overall treatment adherence rate of patients was 16,7%; the highest rate was regular health checkups (84,2%), and the lowest rate was the blood pressure measuring at home (22,5%). The treatment time, education level, support of medical facilities and knowledge are factors related to the hypertension treatment adherence of patients. Conclusion: The hypertension treatment adherence rate of patients was low, 16,7%.
Quality of the services for health examinationandtreatment and some factors affecting in the department ofdistricthealth center of Khanh Son district, Khanh Hoa province in 2023
Authors:   The department ofdistricthealth center of Khanh Son district, Tran Thi Ngoc Tinh , Nguyen Duc Thanh ,   Hanoi University of Public Health
Published: January 2024

A cross-sectional study was conducted from 11/2022 to 06/2023 to describe the quality of medical examination and treatment services (MET) and analyze some influencing factors at the Department of Examination at the District Health Center. Khanh Son Khanh Hoa province. Quantitative research method on 200 patients was conveniently selected, using SERVPERF questionnaire combined with qualitative through in-depth interviews with leaders, managers and patients. The results showed that the percentage of patients who rated the quality of service as good was 89.0%, the highest in the aspect of trust (89.5%), the lowest in the aspect of assurance (84.5%), sympathy and tangibles reached 86.0%, responsiveness reached 87.0%. Factors that positively affect service quality: Applying information technology in MET; good attitude, communication and behavior of medical staff; simple MET process and investment policy to improve hospital quality; Negative factors: Limited investment funds; degraded and narrow facilities; lack of immunoassay machines; professional capacity of medical doctors is not high; lack of specialists; training; policy is not appropriate. Positive factors need to be maintained, negative factors need to be overcome to improve service quality.
The satisfaction of the population using the expanded vaccination services at the Dong Xoai City Health Center, Binh Phuoc Province, in 2023
Authors:   Dong Xoai City Health Center, Trinh Xuan Thieu , Nguyen Thu Huong ,   Hanoi University of Public Health
Published: January 2024

Describe the satisfaction of people using expanded vaccination services at Health Stations of Dong Xoai City Health Center, Binh Phuoc province in 2023. Designed a cross-sectional study on 307 subjects using expanded vaccination services (EPI) at the City Medical Center. Dong Xoai from April 2023 - August 2023. Satisfaction is assessed in 5 aspects based on Decision 3869/QD-BYT. Overall satisfaction rate reached 86.3%. In which, satisfaction with service delivery results reached the highest rate (97.4%), the lowest was in terms of facilities and service facilities (92.2%). People's satisfaction rate with expanded vaccination services is considered quite high, it is necessary to improve the quality of facilities and facilities to serve patients. It is recommended to expand research and evaluation across the entire vaccination program and evaluate other influencing factors. Keywords: Satisfaction; Expanded Program On Immunization, Binh Phuoc province
Relationship between the level of KIAA1199 and some clinical and pathology characteristics of patients with colectal cancer at Duc Giang general hospital in year 2022-2023
Authors:   National Institute for Control and Vaccine and Biologicals, Pham Thi Thu Phuong , Tran Thi Thu Phuong ,   Hanoi University of Public Health, Le Van Thu ,   Hanoi University of Public Health, Ngo Van Lang ,   Hanoi University of Public Health, Nguyen Phuong Thoa ,   Hanoi University of Public Health, Dao Thi Nguyet ,   Duc Giang General Hospital, Nguyen Thuan Loi ,   Bach Mai Hospital, Duong Hong Quan ,   Hanoi University of Public Health
Published: January 2024

Background: Determine the level of KIAA1199 gene copy in FFPE tissue samples of colorectal cancer (CR) patients and evaluate of the relationship between KIAA1199 gene copy level and some clinical and pathological symptoms of CRC patients at Duc Giang General Hospital in year 2022-2023. Methods: A cross-sectional descriptive study on 40 FFPE samples and 40 corresponding medical records of CRC patients diagnosted and treated at Duc Giang General Hospital in year 2022-2023. Result: 26/40 FFPE tissue samples (65.0%) were processed to meet the requirements for RNA extraction quality to evaluate the KIAA1199 gene copy level. Furthermore, 20/26 samples (76.9%) had a higher level of KIAA1199 gene copy in tumor tissue than in normal tissue. There was a statistically significant association between increased KIAA1199 gene copy levels and level of tumor differentiations and types in CR patients (p<0.05); among them, CR patients with neoplasms have increased 11.3 times the KIAA1199 gen copy level higher than CR patients with other types of tumors (p<0.05). However, it was not possible to evaluate the statistically significant relationship between the KIAA1199 gene copy level and some histopathological characteristics such as tumor location, tumor number, histopathological type, level of serosal invasion, lymph node metastasis, and stages classified according to TNM (p>0.05). Conclusion: In this study, the KIAA1199 gene copy levels in tumor tissue increased more strongly than in normal tissue and a statistically significant relationship between the increased KIAA1199 gene copy levels and the tumor differentiations and types in CR patients (p<0.05).
Situation of physical activity among final year medical doctor students at Hanoi Medical University and some related factors
Authors:   Hanoi Medical University, Nguyen Thi Thu Huong , Ho Mai Huong ,   Hanoi Medical University
Published: January 2024

Physical activity helps improve health, prevent disease and improve the quality of life for the community. Objectives: the study aims to: "Describe the current state of physical activity in final-year medical students at Hanoi Medical University in 2023 and analyze some related factors." Method: A cross-sectional study was conducted on 318 final-year medical doctor students of 4 majors (general doctor, preventive medicine, maxillofacial doctor and traditional medicine) studying at Hanoi Medical University. The toolkit is designed to be collected online by investigator. Logistic regression analysis was used to find the association between some factors and recommended physical activity. Results: The main findings showed that the rate of medical students who did not meet the WHO’s recommendations was 46.5%. The percentage of students with severe, moderate, low/no physical activity was 7.2%; 44.3%; and 48.4%, respectively. Multivariate logistic regression showed that the likelihood of having WHO’s recommendation of physical activity among the non-obese groups (BMI<25) was higher than the obese group (BMI≥25) (OR = 2.3; 95%CI: 1 - 5.25); The group with good/excellent academic performance was higher than the group of students with fair academic performance (OR = 1.86; 95% CI: 1.07 - 3.23); and the group without internet addiction was higher than the group with internet addiction (OR=1.66; 95%CI: 1.11 - 2.7). Conclusions: The rate of students with physical activity at the recommended level is not high, there needs to be behavioral changes, healthy living, and increased physical activity in students.
Pulsation in TESS Objects of Interest
Authors: Gomes R. L. , Martins B. L. Canto , Fontinele D. O. , Almeida L. A. , Freire R. Alves , Brito A. C. , de Amorim R. G. S. B. , Lopes C. E. Ferreira , Hazarika D. , Janot-Pacheco E. , Leão I. C. , Messias Y. S. , Souza R. A. A. , De Medeiros J. R.
Published: January 2024

We report the discovery of three Transiting Exoplanet Survey Satellite Objects of Interest (TOI) with signatures of pulsation, observed in more than one sector. Our main goal is to explore how large is the variety of classical pulsators such as δ Sct, γ Dor, RR Lyrae and Cepheid among TOI pulsators. The analysis reveals two stars with signatures of δ Sct and one of γ Dor, out of a sample of 3901 TOIs with available light curves (LCs). To date, there is a very scarce number of known pulsating stars hosting planets. The present finding also emerges as an exciting laboratory for studying different astrophysical phenomena, including the effects of star–planet interaction on pulsation and timing detection of planetary companions. We have also identified 16 TOI stars with periodicities and LCs morphology compatible with different classical pulsating classes, but for most of them, the dominant frequency signals originate from contaminating sources.
AWSoM Magnetohydrodynamic Simulation of a Solar Active Region. II. Statistical Analysis of Alfvén Wave Dissipation and Reflection, Scaling Laws, and Energy Budget on Coronal Loops
Authors: Shi Tong , Manchester Ward , Landi Enrico , van der Holst Bart , Szente Judit , Chen Yuxi , Tóth Gábor , Bertello Luca , Pevtsov Alexander
Published: January 2024

The coronal heating problem has been a major challenge in solar physics, and a tremendous amount of effort has been made over the past several decades to solve it. In this paper, we aim at answering how the physical processes behind the Alfvén wave turbulent heating adopted in the Alfvén Wave Solar atmosphere Model (AWSoM) unfold in individual plasma loops in an active region (AR). We perform comprehensive investigations in a statistical manner on the wave dissipation and reflection, temperature distribution, heating scaling laws, and energy balance along the loops, providing in-depth insights into the energy allocation in the lower solar atmosphere. We demonstrate that our 3D global model with a physics-based phenomenological formulation for the Alfvén wave turbulent heating yields a heating rate exponentially decreasing from loop footpoints to top, which had been empirically assumed in the past literature. A detailed differential emission measure (DEM) analysis of the AR is also performed, and the simulation compares favorably with DEM curves obtained from Hinode/Extreme-ultraviolet Imaging Spectrometer observations. This is the first work to examine the detailed AR energetics of our AWSoM model with high numerical resolution and further demonstrates the capabilities of low-frequency Alfvén wave turbulent heating in producing realistic plasma properties and energetics in an AR.
Ultradeep ATCA Imaging of 47 Tucanae Reveals a Central Compact Radio Source
Authors: Paduano Alessandro , Bahramian Arash , Miller-Jones James C. A. , Kawka Adela , Galvin Tim J. , Rivera Sandoval Liliana , Kamann Sebastian , Strader Jay , Chomiuk Laura , Heinke Craig O. , Maccarone Thomas J. , Dreizler Stefan
Published: January 2024

We present the results of an ultradeep radio continuum survey, containing ∼480 hr of observations, of the Galactic globular cluster 47 Tucanae with the Australia Telescope Compact Array. This comprehensive coverage of the cluster allows us to reach rms noise levels of 1.19 μJy beam−1 at 5.5 GHz, 940 nJy beam−1 at 9 GHz, and 790 nJy beam−1 in a stacked 7.25 GHz image. This is the deepest radio image of a globular cluster and the deepest image ever made with the Australia Telescope Compact Array. We identify ATCA J002405.702-720452.361, a faint (6.3 ± 1.2 μJy at 5.5 GHz, 5.4 ± 0.9 μJy at 9 GHz), flat-spectrum (α = −0.31 ± 0.54) radio source that is positionally coincident with the cluster center and potentially associated with a faint X-ray source. No convincing optical counterpart was identified. We use radio, X-ray, optical, and UV data to show that explanations involving a background active galactic nucleus, a chromospherically active binary, or a binary involving a white dwarf are unlikely. The most plausible explanations are that the source is an undiscovered millisecond pulsar or a weakly accreting black hole. If the X-ray source is associated with the radio source, the fundamental plane of black-hole activity suggests a black hole mass of ∼54–6000 M
⊙, indicating an intermediate-mass black hole or a heavy stellar-mass black hole.
Root hemiparasites suppress invasive alien clonal plants: evidence from a cultivation experiment
Authors: Těšitelová Tamara , Knotková Kateřina , Knotek Adam , Cempírková Hana , Těšitel Jakub
Published: January 2024

Alien invasive plants threaten biodiversity by rapid spread and competitive exclusion of native plant species. Especially, tall clonal invasives can rapidly attain strong dominance in vegetation. Root-hemiparasitic plants are known to suppress the growth of clonal plants by the uptake of resources from their below-ground organs and reduce their abundance. However, root-hemiparasites’ ability to interact with alien clonal plants has not yet been tested.

We explored the interactions between native root-hemiparasitic species, Melampyrum arvense and Rhinanthus alectorolophus and invasive aliens, Solidago gigantea and Symphyotrichum lanceolatum. We investigated the haustorial connections and conducted a pot experiment. We used seeds from wild hemiparasite populations and those cultivated in monostands of the invasive plants to identify a possible selection of lineages with increased compatibility with these alien hosts. The hemiparasitic species significantly suppressed the growth of the invasive plants. Melampyrum inflicted the most substantial growth reduction on Solidago (78%), followed by Rhinanthus (49%). Both hemiparasitic species reduced Symphyotrichum biomass by one-third. Additionally, Melampyrum reduced the shoot density of both host species. We also observed some transgenerational effects possibly facilitating the growth of hemiparasites sourced from subpopulations experienced with the host.

Native root hemiparasites can effectively decrease alien clonal plants’ biomass production and shoot density. The outcomes of these interactions are species-specific and may be associated with the level of clonal integration of the hosts. The putative selection of lineages with higher performance when attached to the invasive novel hosts may increase hemiparasites’ efficiency in future biocontrol applications.
Metabolic Syndrome Is Associated With an Increased Risk of Rheumatoid Arthritis: A Prospective Cohort Study Including 369,065 Participants
Authors: Luo Peiyang , Xu WanLi , Ye Ding , Chen Weiwei , Ying Jiacheng , Liu Bin , Li Jiayu , Sun Xiaohui , He Zhixing , Wen Chengping , Mao Yingying
Published: January 2024

Objective

To explore the associations between metabolic syndrome (MetS) and its individual components and the risk of rheumatoid arthritis (RA).

Methods

A total of 369,065 individuals were included in the present study based on the UK Biobank. Multivariable Cox proportional hazards regression models were applied to estimate the associations between MetS and its individual components and the risk of RA. Mediation analysis was performed to further assess the potential mediating role of C-reactive protein (CRP) in the relationship between MetS and RA.

Results

During a median follow-up period of 12.04 years, a total of 4901 incident RA cases were documented. MetS (hazard ratio [HR] 1.22, 95% CI 1.14-1.30) and 4 of its 5 components (elevated waist circumference [WC; HR 1.21, 95% CI 1.12-1.32], elevated triglyceride [TG] level [HR 1.12, 95% CI 1.05-1.19], reduced high-density lipoprotein cholesterol [HDL-C] level [HR 1.31, 95% CI 1.23-1.39], and hyperglycemia [HR 1.15, 95% CI 1.05-1.25]) were associated with an increased risk of RA. In addition, the risk of RA increased as the number of diagnosed MetS components increased, with the highest risk in participants with all 5 components. Mediation analysis showed that CRP might mediate the association between MetS and RA, accounting for 9.27% of the total effect.

Conclusion

These findings indicated positive associations between MetS and 4 of its components (WC, TG, HDL-C, and hyperglycemia) and the risk of RA, highlighting the importance of MetS management in the prevention of RA.
Association of Serum Soluble Transferrin Receptor Concentration With Markers of Inflammation: Analysis of 1001 Patients From a Tertiary Rheumatology Center
Authors: Günther Florian , Straub Rainer H. , Hartung Wolfgang , Fleck Martin , Ehrenstein Boris , Schminke Louisa
Published: January 2024

Objective

Soluble transferrin receptor (sTfR) is considered to be a useful biomarker for the diagnosis of iron deficiency, especially in the setting of inflammation, as it is thought to not be affected by inflammation. We analyzed the relationship between sTfR levels and inflammatory markers in patients with known or suspected inflammatory rheumatic disease (IRD).

Methods

Blood samples of 1001 patients with known or suspected IRD referred to a tertiary rheumatology center were analyzed. Study participants were classified as patients with active IRD and patients with inactive IRD or without IRD. Correlation analyses were used to explore the relationship between sTfR levels and inflammatory markers (ie, C-reactive protein [CRP], erythrocyte sedimentation rate [ESR]). We applied multiple linear regression analysis to evaluate the predictive value of CRP levels for sTfR concentrations after adjustment for potential confounding factors.

Results

There were positive correlations between inflammatory markers (CRP, ESR) and serum sTfR levels (ρ 0.44, ρ 0.43, respectively;P< 0.001), exceeding the strength of correlation between inflammatory markers and the acute phase reactant ferritin (ρ 0.30, ρ 0.23, respectively;P< 0.001). Patients with active IRD demonstrated higher serum sTfR levels compared to patients with inactive or without IRD (mean 3.99 [SD 1.69] mg/L vs 3.31 [SD 1.57] mg/L;P< 0.001). After adjustment for potential confounding factors, CRP levels are predictive for serum sTfR concentrations (P< 0.001).

Conclusion

The study provides evidence against the concept that sTfR is a biomarker not affected by inflammation.
Patient-Reported Impact of Symptoms in Fibromyalgia (PRISM-FM)
Authors: Weinstein Jennifer , Rosero Spencer , Seabury Jamison , Varma Anika , Engebrecht Charlotte , Khosa Shaweta , Heatwole John , Dilek Nuran , Kaat Aaron , Matallana Lynne Kennedy , Heatwole Chad
Published: January 2024

Objective

To identify the frequency and relative importance of symptoms experienced by adults with fibromyalgia (FM) and determine factors associated with a higher disease burden.

Methods

We conducted semistructured interviews with 15 participants with FM, collecting 1479 quotes regarding the symptomatic burden of FM. We then performed an international cross-sectional study involving 1085 participants with FM to determine the prevalence and relative importance (scale 0-4) of 149 symptoms representing 14 symptomatic themes. We performed subgroup analysis to determine how age, sex, disease duration, medication use, employment status, change in employment status, missing work due to FM, and ability level are related to symptomatic theme prevalence.

Results

The symptomatic themes with the highest prevalence in FM were pain (99.8%), muscle tenderness (99.8%), and fatigue (99.3%). The symptomatic themes that had the greatest effect on patients' lives were related to fatigue (2.88), pain (2.85), muscle tenderness (2.79), and impaired sleep and daytime sleepiness (2.70). Symptomatic theme prevalence was most strongly associated with the modified Rankin Scale level of disability, disability status, and change in employment status (on disability vs not on disability).

Conclusion

Participants with FM identify a variety of symptoms that significantly affect their daily lives. Many of these symptoms, such as fatigue, sleep disturbance, and activity limitation, are life-altering and not related to traditional diagnostic criteria. Symptom prevalence in this population varies across subgroups based on demographic categories and disability status.
Relationship Between Adalimumab Concentrations, Antidrug Antibodies, and Disease Activity in Rheumatoid Arthritis: A Cross-Sectional Observational Study
Authors: Stamp Lisa K. , Keating Paula , Frampton Christopher , Barclay Murray L. , Fanning Niamh , Millier Melanie , Hessian Paul A. , O’Donnell John L.
Published: January 2024

Objectives

To determine the influence of patient characteristics and disease activity on adalimumab (ADA) concentrations; to assess the relationships between ADA concentrations, the presence of antidrug antibodies (ADAb), and disease activity in rheumatoid arthritis (RA); and to determine the association between cytokine concentrations and ADA concentrations.

Methods

A cross-sectional study of people with RA receiving ADA for at least 4 weeks was undertaken. Disease activity was assessed by the Disease Activity Score in 28 joints (DAS28), with responders defined as DAS28 ≤ 3.2. Serum and plasma were obtained for ADA concentrations and ADAb, and a panel of cytokines were obtained for a subgroup. ADA concentrations were compared between demographic and clinical subgroups using ANOVA. The independent associations between clinical and demographic features were analyzed using a general linear model. Variables significantly associated with ADA concentrations from the univariate analyses were entered into multivariate analyses.

Results

Of the 156 participants, 69.2% were female and the mean age was 57.4 (SD 12.7) years. Multivariate analysis revealed that higher C-reactive protein (P< 0.001) and higher weight (P< 0.004) were independently associated with lower ADA concentrations. ADA concentrations were higher in those with DAS28 ≤ 3.2 compared to those with DAS28 > 3.2 (median 10.8 [IQR 6.4-20.8] mg/L vs 7.1 [IQR 1.5-12.6] mg/L,P< 0.001). There was a significant negative correlation between interleukin 6 (IL-6) and ADA concentrations (r= −0.04,P< 0.01).

Conclusion

ADA concentration correlates negatively with markers of inflammatory disease activity in RA, including IL-6. ADA concentration in the range 5 to 7 mg/L over the dose interval are associated with better disease control.