bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and Validation of the Immune Status Questionnaire (ISQ)
Authors: Wilod Versprille Livia J. F. , van de Loo Aurora J. A. E. , Mackus Marlou , Arnoldy Lizanne , Sulzer Titia A. L. , Vermeulen Sterre , Abdulahad Smedra , Huls Hendrikje , Baars Ton , Scholey Andrew , Kraneveld Aletta , Garssen Johan , Verster Joris
Published: November 2019

The self-assessment of perceived immune status is important, as this subjective observation leads individuals to decide whether or not to seek medical help or adapt their lifestyle. In addition, it can be used in clinical settings and research. The aim of this series of studies was to develop and validate a short questionnaire to assess perceived immune functioning. Five surveys were conducted among Dutch and International young healthy adults (18–30 years old), and two others among older age groups with various health complaints. For the first study, an existing immune functioning scale was modified and elaborated resulting in 23 immune-health-related items, of which the occurrence was rated on a 5-point Likert scale. A student sample was surveyed, and the results were used to shorten the 23-item listing into a 7-item scale with a predictive validity of 85%. Items include “sudden high fever”, “diarrhea”, “headache”, “skin problems (e.g., acne and eczema)”, “muscle and joint pain”, “common cold” and “coughing”. The scale is named Immune Status Questionnaire (ISQ), and it aims to assess perceived immune status over the preceding year. The second study revealed that the ISQ score correlated significantly with a 1-item perceived immune functioning (r = 0.383, p < 0.0001). In the third study, the final Likert scale descriptors were determined (“never”, “sometimes”, “regularly”, “often” and “(almost) always)”. The fourth study showed that the test–retest reliability of the ISQ is acceptable (r = 0.80). The fifth study demonstrated the association of ISQ scores with various neuropsychological and health correlates in an international sample, including perceived health and immune fitness, as well as levels of stress, fatigue, depression and anxiety. Study 6 demonstrated significant associations between ISQ scores and experiencing irritable bowel syndrome (IBS) symptoms in a sample of insomnia patients. Study 7 compared the effect of a dietary intervention in participants reporting “poor health” versus “normal health”. It is shown that ISQ scores can differentiate between those with poor and normal health, and that an effective intervention is associated with a significant improvement in ISQ scores. Data from Study 7 were further used to determine an ISQ cut-off value for reduced immune functioning, and a direct comparison with 1-item perceived immune functioning scores enabled constructing the final scoring format of the ISQ. In conclusion, the ISQ has appropriate face, content, and construct validity and is a reliable, stable and valid method to assess the past 12 month’s perceived immune status.
Facilitating Exercise Engagement among Community Dwelling Stroke Survivors: Is a once Per Week Group Session Sufficient?
Authors: Mohd Nordin Nor Azlin , Yusoff Nor Asma Husna , Ajit Singh Devinder Kaur
Published: November 2019

Although exercise is proven as an effective strategy to combat post-stroke complications and the risk of stroke recurrence, many stroke survivors fail to engage in this activity following rehabilitation. In this study, we assessed the feasibility and usefulness of a low-frequency group exercise to determine its suitability as an approach to facilitate exercise engagement among stroke survivors. Forty-one stroke survivors, mean (SD) age 59.34 (10.02) years, mean time post-stroke 17.13 (17.58) months, completed a 90 minute, once per week, group exercise supervised by therapists for 12 weeks. The exercise outcomes were measured using standardized clinical tests. We observed improvement in the group’s physical performance; balance score by 3 units (Z = −3.88, p < 0.001), speed of repetitive sit to stand by 3.4 s (Z = −4.69, p < 0.001), and walking speed by 8.22 m/min (Z = −3.25, p < 0.001). Scores of seven out of 14 Berg’s balance scale items increased significantly, indicating better balance ability among the survivors. In conclusion, a 12-week, once per week group exercise session seems feasible and sufficient to improve the physical performance of community dwelling stroke survivors. This exercise arrangement may be offered to stroke survivors to facilitate exercise practice following rehabilitation.
Rhomboid-Like-2 Intramembrane Protease Mediates Metalloprotease-Independent Regulation of Cadherins
Authors: Battistini Chiara , Rehman Michael , Avolio Marco , Arduin Alessia , Valdembri Donatella , Serini Guido , Tamagnone Luca
Published: November 2019

Cadherins are a major family of cell–cell adhesive receptors, which are implicated in development, tissue homeostasis, and cancer. Here, we show a novel mechanism of post-translational regulation of E-cadherin in cancer cells by an intramembrane protease of the Rhomboid family, RHBDL2, which leads to the shedding of E-cadherin extracellular domain. In addition, our data indicate that RHBDL2 mediates a similar activity on VE-cadherin, which is selectively expressed by endothelial cells. We show that RHBDL2 promotes cell migration, which is consistent with its ability to interfere with the functional role of cadherins as negative regulators of motility; moreover, the two players appear to lie in the same functional pathway. Importantly, we show that RHBDL2 expression is induced by the inflammatory chemokine TNFα. The E-cadherin extracellular domain is known to be released by metalloproteases (MMPs); however, here, we provide evidence of a novel MMP-independent, TNFα inducible, E-cadherin processing mechanism that is mediated by RHBDL2. Thus, the intramembrane protease RHBDL2 is a novel regulator of cadherins promoting cell motility.
Cerium Oxide Nanoparticles Protect against Oxidant Injury and Interfere with Oxidative Mediated Kinase Signaling in Human-Derived Hepatocytes
Authors: Carvajal Silvia , Perramón Meritxell , Casals Gregori , Oró Denise , Ribera Jordi , Morales-Ruiz Manuel , Casals Eudald , Casado Pedro , Melgar-Lesmes Pedro , Fernández-Varo Guillermo , Cutillas Pedro , Puntes Victor , Jiménez Wladimiro
Published: November 2019

Cerium oxide nanoparticles (CeO2NPs) possess powerful antioxidant properties, thus emerging as a potential therapeutic tool in non-alcoholic fatty liver disease (NAFLD) progression, which is characterized by a high presence of reactive oxygen species (ROS). The aim of this study was to elucidate whether CeO2NPs can prevent or attenuate oxidant injury in the hepatic human cell line HepG2 and to investigate the mechanisms involved in this phenomenon. The effect of CeO2NPs on cell viability and ROS scavenging was determined, the differential expression of pro-inflammatory and oxidative stress-related genes was analyzed, and a proteomic analysis was performed to assess the impact of CeO2NPs on cell phosphorylation in human hepatic cells under oxidative stress conditions. CeO2NPs did not modify HepG2 cell viability in basal conditions but reduced H2O2- and lipopolysaccharide (LPS)-induced cell death and prevented H2O2-induced overexpression of MPO, PTGS1 and iNOS. Phosphoproteomic analysis showed that CeO2NPs reverted the H2O2-mediated increase in the phosphorylation of peptides related to cellular proliferation, stress response, and gene transcription regulation, and interfered with H2O2 effects on mTOR, MAPK/ERK, CK2A1 and PKACA signaling pathways. In conclusion, CeO2NPs protect HepG2 cells from cell-induced oxidative damage, reducing ROS generation and inflammatory gene expression as well as regulation of kinase-driven cell survival pathways.
Cellular Factor XIII, a Transglutaminase in Human Corneal Keratocytes
Authors: Orosz Zsuzsanna , Bárdos Helga , Shemirani Amir , Beke Debreceni Ildikó , Lassila Riitta , Riikonen Antti , Kremer Hovinga Johanna , Seiler Theo , van Dorland Hendrika , Schroeder Verena , Boda Zoltán , Nemes László , Früh Eppstein Beatrice , Nagy Bence , Facskó Andrea , Kappelmayer János , Muszbek László
Published: November 2019

Cellular factor XIII (cFXIII, FXIII-A2), a transglutaminase, has been demonstrated in a few cell types. Its main function is to cross-link proteins by isopeptide bonds. Here, we investigated the presence of cFXIII in cells of human cornea. Tissue sections of the cornea were immunostained for FXIII-A in combination with staining for CD34 antigen or isopeptide cross-links. Isolated corneal keratocytes were also evaluated by immunofluorescent microscopy and flow cytometry. FXIII-A in the corneal stroma was quantified by Western blotting. FXIII-A mRNA was detected by RT-qPCR. The cornea of FXIII-A-deficient patients was evaluated by cornea topography. FXIII-A was detected in 68 ± 13% of CD34+ keratocytes. Their distribution in the corneal stroma was unequal; they were most abundant in the subepithelial tertile. cFXIII was of cytoplasmic localization. In the stroma, 3.64 ng cFXIII/mg protein was measured. The synthesis of cFXIII by keratocytes was confirmed by RT-qPCR. Isopeptide cross-links were detected above, but not within the corneal stroma. Slight abnormality of the cornea was detected in six out of nine FXIII-A-deficient patients. The presence of cFXIII in human keratocytes was established for the first time. cFXIII might be involved in maintaining the stability of the cornea and in the corneal wound healing process.
Multiple Signatures of the JC Polyomavirus in Paired Normal and Altered Colorectal Mucosa Indicate a Link with Human Colorectal Cancer, but Not with Cancer Progression
Authors: Uleri Elena , Piu Claudia , Caocci Maurizio , Ibba Gabriele , Sanges Francesca , Pira Giovanna , Murgia Luciano , Barmina Michele , Giannecchini Simone , Porcu Alberto , Serra Caterina , Scanu Antonio M , De Miglio Maria R , Dolei Antonina
Published: November 2019

The JC polyomavirus (JCV) has been repeatedly but discordantly detected in healthy colonic mucosa, adenomatous polyps, and colorectal cancer (CRC), and proposed to contribute to oncogenesis. The controversies may derive from differences in JCV targets, patient’s cohorts, and methods. Studies of simultaneous detection, quantification, and characterization of JCV presence/expression in paired samples of normal/altered tissues of the same patient are lacking. Therefore, we simultaneously quantified JCV presence (DNA) and expression (mRNA and protein) of T-antigen (T-Ag), Viral Protein 1 (Vp1), and miR-J1-5p in paired normal/altered tissues of CRC or polyps, and from controls. JCV signatures were found in most samples. They increased in patients, but were higher in normal mucosa than in corresponding polyp or CRC lesions. JCV non-coding control region (NCCR) DNA rearrangements increased in CRC patients, also in normal mucosa, thus before the onset of the lesion. A new ∆98bp NCCR DNA rearrangement was detected. T-Ag levels were higher in normal mucosa than in adenoma and adenocarcinoma lesions, but decreased to levels of controls in established CRC lesions. In CRC, miR-J1-5p expression decreased with CRC progression. Vp1 expression was not detected. The data indicate a JCV link with the disease, but possible JCV contributes to oncogenesis should occur at pre-polyp stages.
Hot Spots and Their Contribution to the Self-Assembly of the Viral Capsid: In Silico Prediction and Analysis
Authors: Díaz-Valle Armando , Falcón-González José Marcos , Carrillo-Tripp Mauricio
Published: November 2019

The viral capsid is a macromolecular complex formed by a defined number of self-assembled proteins, which, in many cases, are biopolymers with an identical amino acid sequence. Specific protein–protein interactions (PPI) drive the capsid self-assembly process, leading to several distinct protein interfaces. Following the PPI hot spot hypothesis, we present a conservation-based methodology to identify those interface residues hypothesized to be crucial elements on the self-assembly and thermodynamic stability of the capsid. We validate the predictions through a rigorous physical framework which integrates molecular dynamics simulations and free energy calculations by Umbrella sampling and the potential of mean force using an all-atom molecular representation of the capsid proteins of an icosahedral virus in an explicit solvent. Our results show that a single mutation in any of the structure-conserved hot spots significantly perturbs the quaternary protein–protein interaction, decreasing the absolute value of the binding free energy, without altering the protein’s secondary nor tertiary structure. Our conservation-based hot spot prediction methodology can lead to strategies to rationally modulate the capsid’s thermodynamic properties.
Heat-Shock Protein 27 (HSPB1) Is Upregulated and Phosphorylated in Human Platelets during ST-Elevation Myocardial Infarction
Authors: Kraemer Bjoern F. , Mannell Hanna , Lamkemeyer Tobias , Franz-Wachtel Mirita , Lindemann Stephan
Published: November 2019

Heat-shock proteins are a family of proteins which are upregulated in response to stress stimuli including inflammation, oxidative stress, or ischemia. Protective functions of heat-shock proteins have been studied in vascular disease models, and malfunction of heat-shock proteins is associated with vascular disease development. Heat-shock proteins however have not been investigated in human platelets during acute myocardial infarction ex vivo. Using two-dimensional electrophoresis and immunoblotting, we observed that heat-shock protein 27 (HSPB1) levels and phosphorylation are significantly increased in platelets of twelve patients with myocardial infarction compared to patients with nonischemic chest pain (6.4 ± 1.0-fold versus 1.0 ± 0.9-fold and 5.9 ± 1.8-fold versus 1.0 ± 0.8-fold; p < 0.05). HSP27 (HSPB1) showed a distinct and characteristic intracellular translocation from the cytoskeletal fraction into the membrane fraction of platelets during acute myocardial infarction that did not occur in the control group. In this study, we could demonstrate for the first time that HSP27 (HSPB1) is upregulated and phosphorylated in human platelets during myocardial infarction on a cellular level ex vivo with a characteristic intracellular translocation pattern. This HSP27 (HSPB1) phenotype in platelets could thus represent a measurable stress response in myocardial infarction and potentially other acute ischemic events.
Computer-Assisted Design of Environmentally Friendly and Light-Stable Fluorescent Dyes for Textile Applications
Authors: Tang Songsong , Chen Guoqiang , Sun Gang
Published: November 2019

Five potentially environmentally friendly and light-stable hemicyanine dyes were designed based on integrated consideration of photo, environmental, and computational chemistry as well as textile applications. Two of them were synthesized and applied in dyeing polyacrylonitrile (PAN), cotton, and nylon fabrics, and demonstrated the desired properties speculated by the programs. The computer-assisted analytical processes includes estimation of the maximum absorption and emission wavelengths, aquatic environmental toxicity, affinity to fibers, and photo-stability. This procedure could effectively narrow down discovery of new potential dye structures, greatly reduce and prevent complex and expensive preparation processes, and significantly improve the development efficiency of novel environmentally friendly dyes.
Synthesis and Characterization of Hollow Glass Sphere Containing Aluminum Syntactic Foam by Spark Plasma Sintering and Hot Pressing
Authors: Son Yong Guk , Lee Young Cheol , Jung Sung Su , Kwon Han Sang , Lee Wookjin , Park Yongho
Published: November 2019

The effect of sintering process on the microstructure and the mechanical properties of aluminum syntactic foam were investigated in this study. Two different sintering processes of spark plasma sintering and hot pressing were used. Glass hollow spheres with a size of 50–80 μm was used to fabricate the foams having various volume fractions of the spheres in the range of 10–30%. Microstructural analysis revealed that the glass hollow spheres were uniformly distributed in the aluminum matrix, both in the spark plasma sintered and hot pressed ones. As the volume fraction of the spheres increased from 10 to 30%, the density, micro-hardness and compressive strength of the foams were decreased. In comparison to the foams fabricated by hot pressing method, the spark plasma sintered foams had slightly lower density and mechanical strength. In nanoindentation study, it was found that the aluminum matrix in the foam prepared by the spark plasma sintering process had lower strength than foam prepared by the hot pressing process. This is likely because of shorter sintering time used in the spark plasma sintering process than the hot pressing.
MEMS Gyroscope Bias Drift Self-Calibration Based on Noise-Suppressed Mode Reversal
Authors: Gu Haoyu , Zhao Baolin , Zhou Hao , Liu Xianxue , Su Wei
Published: November 2019

This paper presents a bias drift self-calibration method for micro-electromechanical systems (MEMS) gyroscopes based on noise-suppressed mode reversal without the modeling of bias drift signal. At first, the bias drift cancellation is accomplished by periodic switching between operation mode of two collinear gyroscopes and subtracting the bias error which is estimated by the rate outputs from a consecutive period interval; then a novel filtering algorithm based on improved complete ensemble empirical mode decomposition (improved complete ensemble empirical mode decomposition with adaptive noise—CEEMDAN) is applied to eliminate the noise in the calibrated signal. A set of intrinsic mode functions (IMFs) is obtained by the decomposition of the calibrated signal using improved CEEMDAN method, and the threshold denoising method is utilized; finally, the de-noised IMFs are reconstructed into the desired signal. To verify the proposed method, the hardware circuit with an embedded field-programmable gate array (FPGA) was implemented and applied in bias drift calibration for the two MEMS gyroscopes manufactured in our laboratory. The experimental results indicate that the proposed method is feasible, and it achieved a better performance than the typical mode reversal. The bias instability of the two gyroscopes decreased from 0.0066 ° / s and 0.0055 ° / s to 0.0011 ° / s ; and, benefiting from the threshold denoising based on improved CEEMDAN, the angle random walks decreased from 1.18 × 10 − 4 ° / s 1 / 2 and 2.04 × 10 − 4 ° / s 1 / 2 to 2.19 × 10 − 5 ° / s 1 / 2 , respectively.
Comments on the Editor Re: Shi, Zumin, et al. “High Chili Intake and Cognitive Function among 4582 Adults: An Open Cohort Study over 15 Years.” Nutrients 2019, 11(5), 1183
Authors: Wang Yun , Wu Dan
Published: November 2019

We read with great interest the article [...]
Spectral Object Recognition in Hyperspectral Holography with Complex-Domain Denoising
Authors: Shevkunov Igor , Katkovnik Vladimir , Claus Daniel , Pedrini Giancarlo , Petrov Nikolay V. , Egiazarian Karen
Published: November 2019

In this paper, we have applied a recently developed complex-domain hyperspectral denoiser for the object recognition task, which is performed by the correlation analysis of investigated objects’ spectra with the fingerprint spectra from the same object. Extensive experiments carried out on noisy data from digital hyperspectral holography demonstrate a significant enhancement of the recognition accuracy of signals masked by noise, when the advanced noise suppression is applied.
Validation of a Novel Device for the Knee Monitoring of Orthopaedic Patients
Authors: Kayaalp Mahmut Enes , Agres Alison N. , Reichmann Jan , Bashkuev Maxim , Duda Georg N. , Becker Roland
Published: November 2019

Fast-track surgery is becoming increasingly popular, whereas the monitoring of postoperative rehabilitation remains a matter of considerable debate. The aim of this study was to validate a newly developed wearable system intended to monitor knee function and mobility. A sensor system with a nine-degree-of-freedom (DOF) inertial measurement unit (IMU) was developed. Thirteen healthy volunteers performed five 10-meter walking trials with simultaneous sensor and motion capture data collection. The obtained kinematic waveforms were analysed using root mean square error (RMSE) and correlation coefficient (CC) calculations. The Bland–Altman method was used for the agreement of discrete parameters consisting of peak knee angles between systems. To test the reliability, 10 other subjects with sensors walked a track of 10 metres on two consecutive days. The Pearson CC was excellent for the walking data set between both systems (r = 0.96) and very good (r = 0.95) within the sensor system. The RMSE during walking was 5.17° between systems and 6.82° within sensor measurements. No significant differences were detected between the mean values observed, except for the extension angle during the stance phase (E1). Similar results were obtained for the repeatability test. Intra-class correlation coefficients (ICCs) between systems were excellent for the flexion angle during the swing phase (F1); good for the flexion angle during the stance phase (F2) and the re-extension angle, which was calculated by subtracting the extension angle at swing phase (E2) from F2; and moderate for the extension angle during the stance phase (E1), E2 and the range of motion (ROM). ICCs within the sensor measurements were good for the ROM, F2 and re-extension, and moderate for F1, E1 and E2. The study shows that the novel sensor system can record sagittal knee kinematics during walking in healthy subjects comparable to those of a motion capture system.
In-Depth Analysis of Unmodulated Visible Light Positioning Using the Iterated Extended Kalman Filter
Authors: Amsters Robin , Demeester Eric , Stevens Nobby , Slaets Peter
Published: November 2019

Indoor positioning with visible light has become increasingly important in recent years. Usually, light sources are modulated at high speeds in order to wirelessly transmit data from the fixtures to a receiver. The accuracy of such systems can range from a few decimeters to a few centimeters. However, additional modulation hardware is required for every light source, thereby increasing cost and system complexity. This paper investigates the use of unmodulated light for indoor positioning. Contrary to previous work, a Kalman filter is used instead of a particle filter to decrease the computational load. As a result, the update rate of position estimation can be higher. Additionally, more resources could be made available for other tasks (e.g., path planning for autonomous robots). We evaluated the performance of our proposed approach through simulations and experiments. The accuracy depends on a number of parameters, but is generally lower than 0.5 m. Moreover, temporary occlusion of the receiver can be compensated in most cases.
Fringe Phase-Shifting Field Based Fuzzy Quotient Space-Oriented Partial Differential Equations Filtering Method for Gaussian Noise-Induced Phase Error
Authors: Yu Changzhi , Ji Fang , Xue Junpeng , Wang Yajun
Published: November 2019

Traditional filtering methods only focused on improving the peak signal-to-noise ratio of the single fringe pattern, which ignore the filtering effect on phase extraction. Fringe phase-shifting field based fuzzy quotient space-oriented partial differential equations filtering method is proposed to reduce the phase error caused by Gaussian noise while filtering. First, the phase error distribution that is caused by Gaussian noise is analyzed. Furthermore, by introducing the fringe phase-shifting field and the theory of fuzzy quotient space, the modified filtering direction can be adaptively obtained, which transforms the traditional single image filtering into multi-image filtering. Finally, the improved fourth-order oriented partial differential equations with fidelity item filtering method is established. Experiments demonstrated that the proposed method achieves a higher signal-to-noise ratio and lower phase error caused by noise, while also retaining more edge details.
Reverse Dispersion Entropy: A New Complexity Measure for Sensor Signal
Authors: Li Yuxing , Gao Xiang , Wang Long
Published: November 2019

Permutation entropy (PE), as one of the powerful complexity measures for analyzing time series, has advantages of easy implementation and high efficiency. In order to improve the performance of PE, some improved PE methods have been proposed through introducing amplitude information and distance information in recent years. Weighted-permutation entropy (W-PE) weight each arrangement pattern by using variance information, which has good robustness and stability in the case of high noise level and can extract complexity information from data with spike feature or abrupt amplitude change. Dispersion entropy (DE) introduces amplitude information by using the normal cumulative distribution function (NCDF); it not only can detect the change of simultaneous frequency and amplitude, but also is superior to the PE method in distinguishing different data sets. Reverse permutation entropy (RPE) is defined as the distance to white noise in the opposite trend with PE and W-PE, which has high stability for time series with varying lengths. To further improve the performance of PE, we propose a new complexity measure for analyzing time series, and term it as reverse dispersion entropy (RDE). RDE takes PE as its theoretical basis and combines the advantages of DE and RPE by introducing amplitude information and distance information. Simulation experiments were carried out on simulated and sensor signals, including mutation signal detection under different parameters, noise robustness testing, stability testing under different signal-to-noise ratios (SNRs), and distinguishing real data for different kinds of ships and faults. The experimental results show, compared with PE, W-PE, RPE, and DE, that RDE has better performance in detecting abrupt signal and noise robustness testing, and has better stability for simulated and sensor signal. Moreover, it also shows higher distinguishing ability than the other four kinds of PE for sensor signals.
Tag Localization with Asynchronous Inertial-Based Shifting and Trilateration
Authors: Alma’aitah Abdallah Y. , Eslim Lobna M. , Hassanein Hossam S.
Published: November 2019

Personal Area Networks (PAN) are key topologies in pervasive Internet of Things (IoT) localization applications. In the numerous object localization techniques, centralization and synchronization between the elements are assumed. In this paper, we leverage crowdsourcing from multiple fixed and mobile elements to enhance object localization. A cooperative crowdsourcing scheme is proposed to localize mobile low power tags using distributed and mobile/fixed readers for GPS assisted environments (i.e., outdoor) and fixed readers for indoors. We propose Inertial-Based Shifting and Trilateration (IBST) technique to provide an accurate reckoning of the absolute location of mobile tags. The novelty in our technique is its capability to estimate tag locations even when the tag is not covered by three readers to perform trilateration. In addition, IBST provides scalability since no processing is required by the low power tags. IBST technique is validated through extensive simulations using MATLAB. Simulation results show that IBST consistently estimates location, while other indoor localization solutions fail to provide such estimates as the state-of-the-art techniques require localization data to be available simultaneously to provide location estimation.
PENGARUH TERAPI MUSIK TRADISIONAL CINA TERHADAP KESEPIAN PADA LANSIA DI PANTI JOMPO YAYASAN GUNA BUDI BAKTI KELURAHAN MARTUBUNG KECAMATAN MEDAN LABUHAN KOTA MEDAN TAHUN 2019
Authors: Arlis Arlis
Published: November 2019

Loneliness in the elderly is a common thing where they feel feelings of isolation, exclusion, lack of attention from those around them, isolated from others. Traditional music is ethnic music originating from each region and even tribe, this music has a regular rhythm so that it can create relaxation and optimal resting conditions. This study used the Quasi Experiment Design with the onegroup pre and post test design method. The purpose of this study was to determine the effect of traditional Chinese music therapy on loneliness in the elderly. The population in this study amounted to 70 people with a sample of 41 people using Purposive Sampling techniques. Data collection uses the Ucla Loneliness Scale Version 3 questionnaire. The results of the Paired Sample T-Test statistic obtained p-value 0,000 <0.05, which means that there is an influence of traditional Chinese music therapy on loneliness in the elderly. Based on the results of these studies, traditional Chinese music therapy can be used as an alternative to reduce loneliness.
HUBUNGAN MOTIVASI KERJA DENGAN KINERJA PERAWAT DI RUMAH SAKIT UMUM ROYAL PRIMA MEDAN TAHUN 2017
Authors: Chiuman Linda
Published: November 2019

Nursing services in hospital healthcare service is one of the crucial factors in defining the image and quality of a hospital. Nurse, a profession which has the highest amount of interaction with the patients and their family, is one of the core elements in determining the quality of healthcare service of a hospital. The purpose of this research is to discover the relation between internal as well as external motivations and the work related performance of the nurses, particularly those who are stationed at the wards in Royal Prima General Hospital Medan. The methodology used analytical study on the survey with cross-sectional approach. The respondents of the survey are all of the nurses who are stationed at the wards with total number of 168 respondents and the sampling method uses proportional random sampling method towards 110 respondents. The data obtained is analyzed with univariate, bivariate methods utilizing chi square as well as multivariate method utilizing double logistic binary regression test analysis with 5% of confidence interval.The outcome of the research shown that there are relations between internal as well as external motivations and work related performance of the nurses. Nurses with higher value of internal motivations have the chance of 3.061 times to perform better than those with lower value of internal motivations. Additionally, nurses with higher value of external motivations have the chance of 2.761 times to perform better than those with lower value of external motivations. Hence, it is much recommended to the hospital management boards to pay more attention towards the performance of the nurses by considering of giving incentives and rewards to the nurses based on their achievements and loyalty.
HUBUNGAN PERAWATAN TALI PUSAT DENGAN KEJADIAN INFEKSI PADA BAYI BARU LAHIR DI RSUD Dr. PIRNGADI MEDAN 2019
Authors: Damanik Rani
Published: November 2019

Umbilical cord care is one treatment procedure that aims to treat the umbilical cord in newborns to keep it dry and prevent infection. Improper treatment of the umbilical cord in an infant will experience an infectious disease. This study uses a correlation design with a cross sectional approach is something that connects / analyzes the variables that aim to determine the relationship of umbilical cord care with the incidence of infection in newborns (BBL) in RSUD Dr. Pirngadi Hospital Medan 2018, with a sample of 35 respondents. The instruments included demographic data, 20 umbilical cord care questionnaires and observation sheets for infection. Based on the results of this study, the majority of people doing good umbilical cord care (score 14-20) as many as 30 (85.7%) while the minority of respondents doing umbilical cord care enough (score 7-13) as many as 5 people (14.2%). the majority did not experience an infection score of 0 (zero) as many as 33 people (94.3%) and the minority experienced infection score 1-5 as many as 2 people (5.7%). Based on Chi Square test, p = 0.017 <0.05 means that Ho is rejected and Ha is accepted. This shows a relationship between cord care and the incidence of infection in newborns (BBL). It is expected that nurses to carry out umbilical cord care measures more effectively in accordance with the SOP so as to avoid the number of infections in newborns and the next researcher makes an observation sheet in measuring cord care performed by nurses.
EFEKTIVITAS TERAPI HIPNOTIS LIMA JARI TERHADAP KECEMASAN IBU PRE PARTUM DI KLINIK CHELSEA HUSADA TANJUNG BERINGIN KABUPATEN SERDANG BEDAGAI
Authors: Marbun Agnes
Published: November 2019

Labor in pregnant women will result in various psychological problems for pregnant women, one of which is anxiety. Anxiety in pregnant women if not handled seriously will have an impact on the physical and psychological effects, both on the mother and on the fetus. One non-pharmacological therapy that can reduce anxiety is five-finger hypnosis, where this therapy can reduce muscle tension, help focus attention and reduce fear. The purpose of this study was to determine the effectiveness of five-finger hypnosis therapy on pre-partum maternal anxiety. This study uses the one group pre and post test quasy experiment method which aims to determine the effectiveness of before and after five finger hypnosis therapy on pre-partum maternal anxiety. The population was in this study were all pre-partum mothers of 180 people. The sampling technique uses a quota sampling of 15 people. The measuring instrument uses an anxiety questionnaire, the Hamilton Anxiety Rating Scale. Analysis is using the Wilcoxon test with p value <0.005. The results showed that the effectiveness of five-finger hypnosis therapy on pre-partum maternal anxiety resulted in p value = 0.001. It is recommended to the clinic to be able to provide information about the action of five-finger hypnosis therapy and can train pregnant women who will give birth so that the mother can know the benefits and the right way to eliminate anxiety at the time of delivery
Perancangan dan Pembuatan Sistem Alat Pengendalian pada Kipas Angin Menggunakan PIR (PASSIVE INFRARED RECEVIER) dan Arduino Berbasis Android
Authors: Sitanggang Delima , Aloina Grace , Ridho Muhammand
Published: November 2019

Sistem kendali yang berbasis mikrokontroler Arduino, bluetooth HC-05 telah banyak digunakan dalam berbagai aspek kegiatan manusia. Banyak aplikasi di smartphone berbasis android dengan mikrokontroler telah membantu pengguna secara efektif dan efisien dalam pengontrolan jarak jauh maupun jarak dekat. Kipas angin banyak digunakan di Indonesia, tetapi masih menggunakan secara manual. Hal tersebut menyebabkan inefisiensi penggunaan listrik karena sering ditinggalkan dalam kondisi hidup.Pada penelitian sebelumnya sistem kontrol kipas angin otomatis menggunakan sensor suhu LM35 digunakan untuk mendeteksi suhu ruangan. Penelitian ini dilakukan dengan metode studi pustaka, yaitu membaca dan mempelajari literatur-literatur yang berhubungan dengan penelitan tersebut. Penelitian ini bertujuan meningkatkan efektivitas penggunaaan kipas angin. Penelitian ini merancang suatu sistem dimana kipas angin akan hidup jika ada orang yang berada didekatnya.Rancangan sistem ini menggunakan sensor PIR sebagai alat pendeteksi keberadaan manusia. Jadi dengan adanya alat bantu yang dibuat nantinya, seseorang tidak perlu lagi menekan tombol on/off atau tombol yang lainnya pada kipas angin tersebut, pada giliranya akan memberikan efektifitas penggunaan kipas angin.
Implementasi Metode K-Means Clustering Dalam Sistem Pemilihan Jurusan Di SMK Swasta Harapan Baru
Authors: Lase Yerianus , Panggabean Erwin
Published: November 2019

SMK Swasta Harapan Baru memiliki dua jurusan yang dapat dipilih oleh siswa/siswinya, yaitu jurusan Teknik Kendaraan Ringan (TKR) dan jurusan Rekayasa Perangkat Lunak (RPL). Pemilihan jurusan merupakan hak dari siswa/siswi, namun kesalahan pemilihan jurusan dapat menyebabkan penurunan motivasi belajar dan rendahnya prestasi siswa/siswi. Permasalahan ini dapat diselesaikan dengan menggunakan metode K-Means Clustering. Proses pengelompokan data ini dilakukan berdasarkan kemiripan data antar kelompok pada titik tengah (cluster) dari 2 jurusan. Means merupakan metode yang membutuhkan parameter input sebanyak K dan membagi sekumpulan n objek ke dalam K cluster sehingga tingkat kemiripan antar anggota dalam suatu cluster tinggi, sedangkan tingkat kemiripan dengan anggota pada cluster lain sangat rendah. Setiap data siswa dihitung jarak kedekatannya dengan centroid dari masing-masing jurusan, setelah itu dilakukan update terhadap nilai centroid berdasarkan nilai rata-rata dari masing-masing kelompok. Bila nilai centroid masih berubah, maka dilakukan perhitungan jarak ulang hingga nilai centroid tidak berubah, dan data clustering stabil. Hasil penelitian adalah aplikasi dapat digunakan untuk membantu proses pemilihan jurusan pada siswa SMK Swasta Harapan Baru secara otomatis, sehingga dapat membantu siswa/siswi yang masih bingung dengan pemilihan jurusan dan dapat menghindari kesalahan dalam pemilihan jurusan.
Evaluasi Tata Kelola Teknologi Informasi berbasis COBIT 5 pada Badan Pendapatan Daerah Kabupaten Badung
Authors: Sinta Putu Hary , Swastika I Putu Agus , Raditya Putra I Gst Lanang Agung
Published: November 2019

Badan Pendapatan Daerah Kabupaten Badung Dinas Pendapatan/Pasedahan Agung Kabupaten Badung merupakan organisasi perangkat daerah yang memiliki tujuan pokok dan fungsi mengelola pendapatan daerah. Pengelolaan pendapatan daerah tersebut sebagai sumber pembiayaan daerah dalam melaksanakan pembangunan daerah. Diperlukan suatu kerangka kerja sebagai reference model, untuk memastikan kualitas tata kelola TI pada Badan Pendapatan Daerah Kabupaten Badung. Audit Tata kelola teknologi informasi (TI) diperlukan agar sesuai dengan kerangka kerja tata kelola TI dan mengacu pada standar Control Objective for Information and Related Technology (COBIT). Kerangka kerja COBIT ini memberikan solusi dalam menerapkan model tata kelola TI. Penelitian ini fokus pada domain EDM 4, APO 1, APO 7, BAI 4, BAI 9, DSS 1, MEA 1. Menghasilkan temuan bahwa Tata Kelola Teknologi Informasi pada Badan Pendapatan Daerah Kabupaten Badung telah melaksanakan hampir semua katifitas TI dan mempunyai tingkat kematangan 3 (Established).
Crystal aggregates with induced morphologies grown by silica gel technique
Authors: Garcia-Ruiz Juan Manuel , Amorós Portolés José Luis
Published: November 2019

This paper deals with the genetic mechanism of the morphologies present in BaCO₃and CaCO₃ grown by silica gel technique at basic pH. Our results show that a siliceous matrix acting as support induces the whole morphology of the aggregate. Earlier, the existence of such a membrane was inferred from physico-chemical conditions required by the growth technique. In the present research, the experimental proof of its existence is given, as well as the logical arguments required.
An approach to a quantum-mechanical model for solid solutions
Authors: Cloke Paul L.
Published: November 2019

Band gaps calculated theoretically by Kunz, De Cicco, and others, using the augmented plane wave approximation to obtain solutions to the Schrödinger equation, are first shown to yield, utilizing the equation proposed by Van Vechten, good estimation (± 10 %) of the enthalpies of formation of the six alkali halides, NaCl, KCl, NaI, NaBr, LiCl, and LiI over the temperature range 298 K to 900 K, taking account of the changes in lattice constant, band gaps, and ionicities as a function of temperature. This result, together with the remarkable success achieved by Van Vechten in estimating enthalpies of formation of numerous semiconductor compounds and predicting phase diagrams in semiconductor alloy systems suggests strongly that the equation is of general validity.

Nevertheless, when applied to the NaCl-KCl system, with the assumption of linear variation of the lattice constants, ionicities, and band gaps between end members, the equation fails to predict the solvus. Because the lattice constants and ionicities must surely vary approximately linearly with composition, large deviations from linearity must be ascribed to the band gaps, a result again in concordance with theoretical and experimental results reported for semiconductor compounds. In this paper these deviations are arbitrarily assumed to be approximately parabolic, first with the parabolic axis oriented perpendicular to the compositional axis, which yields a reasonable fit to the observed solvus, and then with a rotation of about one degree, which yields an exact fit. Ideal entropy of mixing has been assumed, although this seems rather unlikely in view of the large enthalpy of mixing.

As compared to the two parameter Margules equation, which is widely used to model solid solutions in applications to metamorphic petrology, the two band quantum dielectric model predicts activities differing by up to nearly 600 %, depending upon the component and the composition.
Interprétation du spectre infrarouge de variétés isotopiques de pyropes synthétiques
Authors: Cahay René , Tarte Pierre , Fransolet André-Mathieu
Published: November 2019

3 échantillons de pyrope pur Mg₃Al₂Si₃O₁₂, ²⁶Mg₃Al₂Si₃O₁₂ et Mg₃Al₂³⁰Si₃O₁₂ ont été synthétisés à 1 000 °C et 25 kbar.

Les spectres infrarouges de ces composés montrent que le remplacement isotopique ²⁸Si — ³⁰Si provoque, pour toutes les bandes situées au-dessus de 500 cm⁻¹, un décalage de fréquence significatif, tandis qu'on n'observe, pour ces mêmes bandes, aucune modification liée au remplacement ²⁴Mg — ²⁶Mg : ceci confirme définitivement l'attribution de ces bandes à des vibrations des groupes SiO₄.

En revanche, les bandes observées en dessous de 500 cm⁻¹, subissent un décalage de fréquence, quel que soit le type de remplacement isotopique envisagé. On doit donc, dans ce cas, renoncer à l'hypothèse de vibrations localisées, spécifiques des modes internes des groupes SiO₄ ou des translations des cations Mg²⁺ et considérer l'existence de vibrations complexes auxquelles participent simultanément les tétraèdres SiO₄, les cations Mg²⁺ et aussi probablement Al³⁺.

Le spectre infrarouge du pyrope synthétique se différencie de celui du pyrope naturel par des fréquences légèrement plus élevées et par des bandes plus fines. Ceci est lié à l'accroissement des dimensions de la maille lors de la substitution de Mg par Fe et surtout par Ca dans le pyrope naturel.
On enhanced vector symmetry and homometry in polytype
Authors: Ohsumi Kazumasa , Nowacki Werner
Published: November 2019

Pour déterminer la symétrie d'un cristal ou une structure cristalline, on utilise généralement la méthode de diffraction. Cependant, les figures de diffraction d'un cristal dépendent plus directement du réseau vectoriel du cristal que de la structure elle-même. Donc, le relèvement de la symétrie vectorielle (l'élévation de la symétrie par diffraction ; Sadanaga et Takeda, 1968) et l'homométrie peuvent être traités de manière presque identique et considérés comme le problème de la correspondance entre une structure cristalline et son réseau vectoriel.

A la suite de l'étude récente déterminant les conditions nécessaires à une structure pour avoir une symétrie vectorielle augmentée (Sadanaga et Ohsumi, 1979), nous développons l'étude des rapports entre un accroissement de la symétrie vectorielle et une homométrie, ce qui conduit, dans le cas d'autohomométrie, à l'existence d'une structure à symétrie vectorielle augmentée ayant un correspondant homométrique.

La recherche d'exemples ayant cette complexité structurale conduit à deux sortes de conditions suffisantes pour qu'un polytype MX — ou MX₂ — ait une symétrie vectorielle accrue et une homométrie, comme le polytype 20 Hq CdI₂ de la littérature.
Chemical composition of fluid inclusions in the ore-forming minerals of antimony-mercury-arsenic deposits
Authors: Otkhmezuri Z. V. , Dolidze I. D.
Published: November 2019

Chemical composition of ore-forming minerals in antimony, mercury, mercury-arsenic and arsenic (realgar orpiment) deposits on the southern slope of the Great Caucasus has been investigated. These deposits represent medium and low-temperature formations, developing stage-by stage in quartz-antimonite, quartz-dickite-carbonate-cinnabar and realgar-orpiment stages of mineralization. Chemical composition of fluid inclusions, investigated by the method of triple water extractions shows the evolution of ore-forming solutions from chlorine-sodium at initial (quartz-antimonite) stage to hydrocarbonate-magnesium-calcium composition in the final (realgar-orpiment) stage of mineralization.
The distinctive suite of platinum-group minerals from Guma Water, Sierra Leone
Authors: Bowles John F. W.
Published: November 2019

Alluvial platinum was obtained from rivers draining the western edge of the Freetown Intrusion, Sierra Leone from 1929 to 1949, although the precise source of the platinum is obscured by the jungle and the depth of weathering. Recently, eluvial material from the area of Guma Water has been examined using an electron microprobe and a scanning electron microscope. In addition to platinum-iron and osmium-iridium-ruthenium alloys, distinctive pyritohedra of laurite (RuS₂) and erlichmanite (OsS₂) occur with tulameenite (Pt₂FeCu). Although some of the material is rounded from transport, many of the minerals preserve their original euhedral form and are large compared with those normally found. This preliminary study records the overall appearance of these minerals and their composition with representative electron microprobe analyses.
Mineralogical study of complex Pt-Fe nuggets from Ethiopia
Authors: Cabri Louis J. , Criddle Alan J. , Laflamme J. H. Gilles , Bearne Graham S. , Harris Donald C.
Published: November 2019

Goethite-coated eluvial (?) and fresh-looking (alluvial ?) Pt-Fe nuggets from Joubdo stream, Birbir River are very variable in external morphology from rounded, flattened to very irregular with sharp projections. Scanning electron microscopy has revealed crystalline details of the Pt-Fe alloys at magnifications not reported previously. The most common Pt-Fe alloy is Pt₃Fe, probably isoferroplatinum, but tulameenite and tetraferroplatinum are also present. A combined electron probe and quantitative optical study has documented an extensive suite of primary inclusions in Pt-Fe alloy matrix : osmium, irarsite, erlichmanite, genkinite (second world occurrence), hollingworthite, laurite, stibiopalladinite, cuprian gold, bornite, chalcopyrite, cubanite, chromite, magnetite, diopside (?), ferroaugite (?), forsterite (?), rhodian « pentlandite » (?), unnamed RhSbS (Raicevic and Cabri, 1976), and unnamed Rh₂S₃ (Begizov et al., 1975). In addition, unnamed minerals reported for the first time include : Pt(Rh, Ir)CuS₄, Rh(Te, Bi)₂, and unidentified anisotropic Fe — Rh — Ni and Fe — Ni — Ir — Rh sulphides.

Genkinite and osmium are the only platinum-group minerals exhibiting alteration to secondary minerals, the latter to an unidentified iridium-rich alteration product.
Discovery of metallic residues of the Rochechouart meteorite in basement rocks
Authors: Horn Wolfgang , El Goresy Ahmed
Published: November 2019

The Rochechouart structure of Triassic or early Jurassic age is deeply eroded to the level of the crater floor. At Champonger, the crater floor could be recognized by the association of shatter cones in shocked basement rocks overlain by low temperature suevite. Metal veinlets and particles were found to occur in Champonger basement gneisses within shock produced inter- and intragranular microfractures in various minerals.

The metals very probably are condensates of the vaporized impacting projectile and were probably implanted as metal vapor. The condensed metallic vapor was tightly sealed within these fractures. The metals consist of an alloy containing on the average 73 wt. % Fe, 17 wt. % Cr and 8 wt. % Ni. No Mn was found, small amounts of Co may be present. Due to the high Cr content we suggest that the Rochechouart meteorite was a stony and not an iron as previously proposed by Janssens et al. (1977).