bluuebunny/crossref_metadata_2025 huggingface dataset:
Epidemiology and clinical significance of pLVPK-like virulence plasmid in KPC-2-producing Klebsiella pneumoniae infections in eastern China: a preliminary exploration
Authors: Xu Min , Yang Qing , Liu Yanchao , Chen Xiao , Kong Haishen , Fu Zhangrong , Chen Yu , Fu Yiqi
Published: August 2020

Background: By acquiring a pLVPK-like virulence plasmid (pVir), Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-kp) evolves to a hypervirulent variant, with increasing cases reported worldwide. However, little is known about the epidemiological trend of pVir in KPC-kp, as well as clinical characteristics of infections caused by this novel strain (pVir+-KPC-kp). Methods: From 2014-2018, 662 carbapenem-resistant K. pneumoniae (CRKP) were consecutively collected from a tertiary hospital of eastern China. The confirmed KPC-kp were subjected to antimicrobial susceptibility testing, multilocus sequence typing and detection of pLVPK-related genetic loci (rmpA, rmpA2, iucA and iroN) to identify pVir+-KPC-kp strains. Then, the clinical characteristics and outcomes of KPC-kp infection patients with and without pVir were compared. Moreover, the risk factors for pVir+-KPC-kp infections also determined by a multivariable logistic regression analysis.Results: of the 662 CRKP, 86.6% (573/662) were KPC-kp including 285 (49.7%) pVir+-KPC-kp and 288 (50.3%) pVir--KPC-kp. Notably, the prevalence of pVir+-KPC-kp by year increased remarkably from 2014 (19.5%, 8/41) to 2018 (60.0%, 90/150). Sequence type (ST) 11 was the most predominant ST, accounting for 88.9% of all pVir+-KPC-kp. For the 352 KPC-kp infection cases (186 with pVir+-KPC-kp and 166 with pVir--KPC-kp), multivariable analysis indicated neurosurgery (Odds ratio [OR], 2.92; 95% confidence interval [CI], 1.48-5.75; P =0.002) was independently associated with pVir+-KPC-kp infections. Although patients with pVir+-KPC-kp infections had higher incidence of septic shock (31.2% vs. 21.1%, P =0.03), the two groups showed no significant differences in 7-day mortality (23.1% vs. 18.1%, P =0.24) or 28-day mortality (45.7% vs. 44.0%, P =0.75). Conclusions: Altogether, wide dissemination of pVir in ST11 KPC-kp has emerged in China. Neurosurgery is an independent risk factor for acquisition of pVir+-KPC-kp infections. The mortality rates were similar between patients infected with pVir+-KPC-kp or pVir--KPC-kp, suggesting uncertain impact of pVir in clinical outcome.
Banking strategic management and business model: bibliometric analysis
Authors: Kryvych Yana , Goncharenko Tetiana
Published: August 2020

The article is devoted to the analysis of tendencies and research of approaches to the definition of strategic management of the bank in the scientific literature, to the identification of future perspective directions of research of this problem. VOSviewer software was used for bibliometric analysis, the object of the study was 5901 articles in scientific journals indexed by Scopus and Web of Science scientific databases, the study period was the time interval from 1991 to 2019. The article substantiates that in 2007-2009 the focus of the study has shifted from general strategic management issues to risk management issues of the bank’s business strategy. In 2019, the number of papers devoted to strategic bank management increased rapidly – by 343% compared to 2007. The use of the VOSviewer tool revealed 5 clusters of the relationship between strategic bank management theory and other theories based on scientific concepts. The largest research cluster combines the expertise of researchers who study strategic bank management in close connection with concepts that study the bank’s business models, business strategy, competition, banking performance, banking services, and more. The second-largest cluster brought together scholars who study the theory of strategic bank management at the intersection with the theories of strategic planning, finance, commerce, e-commerce, management, information management, planning, investing, technological development, and more. The third-largest cluster brings together scholars who consider strategic bank management through the lens of corporate governance, corporate strategy, financial market trends, retail banking, bank profitability, and more. The conducted research leads to the conclusion that business strategy, profitability, and strategic risk management are the priority components of banking strategic management. Keywords: bank, banking, strategy, strategic management, business strategy, business model.
THE USE OF NON-TRADITIONAL RAW MATERIALS AT MAKING SOUR-MILK PRODUCTS
Authors: Biletska Yana , Dyukareva Galina , Danko Natalia
Published: August 2020

The results of using flour of sprouted soya and chickpea at making sour-milk products, based on goat milk, are presented. The object of the study is sour milk products, based on goat milk with using flour of sprouted leguminous, enriched with iodine and selenium with the associated use of acidophilic baccilus Lactobacillus acidophilus and bifidobacteria Bifidobacterium lactis.

One of today problems is a deficiency of iodine and selenium, coming to the human organism with food in organically available forms. In this connection the development of new sour-milk products that are carriers of organic forms of microelements with organoleptic characteristics, usual for consumers, is an important task. At the research the dependence of changes of organoleptic parameters of sour-milk product quality has been established.

It has been determined, that it is expedient to use flour, enriched with iodine and selenium in amount 2 % of the sour-milk product mass. Introduction of the aforesaid amount of flour in a sour-milk product favors the improvement of organoleptic parameters and gives developed products a special dietetic destination. At consuming 100 g of a sour-milk vegetable product, 16.8 and 24.5 % of the daily need in iodine and selenium (respectively) is covered.

Based on the obtained results, the recipe of a sour milk product that provides the use of goat milk in amount 93 %, flour of sprouted leguminous (1:1) in amount 2 %, acidophilic bacillus Lactobacillus acidophilus and bifidobacteria Bifidobacterium lactis in amount 5 % of the product mass has been elaborated.

Comparing with analogous known methods, the offered method provides a series of advantages. The most important of them are organoleptic parameters of a ready product, usual for consumers, and its safe enrichment with iodine and selenium. It takes place at the expanse of using organic forms of microelements that excludes a possibility of accumulation in the organism
Gestão da Educação com Justiça Social. Que Gestão dos Injustiçados?
Authors: Arroyo Miguel Gonzalez
Published: August 2020

O texto destaca a radicalidade política de propor uma Gestão da Educação com resistência ativa para uma agenda democrática com justiça social. Que gestão da educação e que formação de gestores? Que exigências para a formação de gestores-educadores? O texto prioriza um olhar político: reafirmar a gestão da educação na razão gestora do Estado, no como o Estado administra os Outros, os oprimidos nas relações políticas de poder. O texto dá centralidade à gestão da educação com justiça social: Que justiça social em tempos de justiça justiceira, produtora de injustiçados? Que formação de gestores para a gestão dos injustiçados resistentes?
A política de contratação de professores temporários em Portel (PA)
Authors: Feldman Ariel , Alves Charles Alberto de Souza
Published: August 2020

A pesquisa analisa a relação entre contratação de professores temporários e disputa pelo poder local em Portel (PA). Trata-se de estudo de caso descritivo e exploratório, em abordagem qualitativa, pautado em referencial teórico que privilegia um enfoque a partir do município. Realizou-se pesquisa in loco em janeiro de 2018, além de análise bibliográfica e documental. O resultado da pesquisa demonstra a importância da indicação de professores temporários na disputa pelo poder local, bem como indícios de que relações de natureza clientelísticas são a base dessas contratações.
A POLÍTICA DE FORMAÇÃO CONTINUADA DO PACTO NACIONAL PELA ALFABETIZAÇÃO NA IDADE CERTA E A APRENDIZAGEM DOS ALFABETIZADORES CURSISTAS
Authors: Soares Aureliano Francisca Edilma Braga , Silva Júnior Luiz Carlos da Costa
Published: August 2020

Este trabalho objetiva analisar às aprendizagens construídas no contexto do PNAIC por professoras que lecionam no ciclo de alfabetização em uma escola pública do município de Patu/RN. A pesquisa foi realizada no Grupo de Pesquisa: Formação, Currículo e Ensino da Universidade do Estado do Rio Grande do Norte entre 2017 e 2018. A análise teórica, documental e empírica seguiu os princípios do método histórico dialético. Constatou-se que as docentes se apropriaram de alguns princípios que constituem os conceitos orientados pelo PNAIC, mas outros se encontram em processo de internalização.
O DEBATE SOBRE FEDERALISMO NA ANPAE (2007-2018)
Authors: Ferreira Eliza Bartolozzi , Alves Ferreira Andreza
Published: August 2020

O artigo analisa o debate sobre federalismo nas produções da ANPAE (2007 e 2018). A política educacional é compreendida como um campo que tem suas próprias normas, valores, interesses, instituições. O software Iramuteq é utilizado como ferramenta para processar o corpus textual. A categorização temática (BARDIN, 2011) identificou os tipos de pesquisa, as metodologias e teorias empregadas nos trabalhos. Concluímos que as produções acadêmicas no âmbito da ANPAE sinalizam disputas em torno do direito à educação e a importância da apropriação do federalismo como princípio da pactuação.
Implicações do Ambiente Físico de Aprendizagem na Formação de Mestres Profissionais em Administração
Authors: Silva Mary Dayane Souza
Published: August 2020

O pensamento acadêmico contemporâneo sugere que o professor não pode limitar-se apenas a dar aulas. É necessário também que crie um ambiente de aprendizagem no qual o aluno seja levado a compartilhar conhecimento em sala de forma aberta, fluida e espontânea, acompanhado por igual crescimento de sua compreensão como elemento ativo-participativo no aprendizado construído a partir desse ambiente. A presente pesquisa objetivou compreender as implicações do ambiente físico de aprendizagem na formação de mestres profissionais de administração. Os dados foram coletados por meio de entrevistas e foram analisados qualitativamente. Os resultados indicam que a disposição do mobiliário de forma circular em sala de aula, articulada a partir da organização mobiliar formalmente estabelecida, constitui um ambiente eficazmente dinâmico de aprendizagem em que há um nítido desenvolvimento da interação de forma mais ativa e participativa dos alunos a partir desse tipo de formação no encadeamento da condução da aula, oportunizando a gestão de espaços de ensino benéficos a aprendizagem.
ANIMAIS DE ESTIMAÇÃO EM CONDOMÍNIO EDILÍCIO: UM ESTUDO COM BASE NO DIREITO DE PROPRIEDADE
Authors: André Victor Conte
Published: August 2020

O presente trabalho tem o objetivo investigar a respeito da legalidade e dos limites das normas condominiais restritivas de animais de estimação em condomínio edilício, apresentando uma conclusão de como o assunto deve ser tratado e solucionado na prática. Para o desenvolvimento da pesquisa foi utilizado o método da revisão bibliográfica, por meio de um estudo cuidadoso da legislação, de livros dos mais renomados autores e da jurisprudência. O tema é atual e possui destacada relevância, pois um número cada vez mais alto de pessoas se encontra vivendo em condomínio edilício ao passo em que houve um aumento do número de animais de estimação nesse tipo de imóvel, havendo contradições entre as regras condominiais restritivas de animais domésticos e o direito de propriedade do condômino. A conclusão que se chega é que se figura como abusiva a restrição estabelecida se inexiste qualquer fato que revele o animal representar efetivo prejuízo à saúde, ao sossego e à segurança dos demais condôminos ou moradores do prédio. A proibição constitui uma violação ao livre exercício do direito de propriedade. É direito do proprietário ou possuidor da unidade ter um animal de estimação em sua residência, podendo se deslocar com o seu animal pelas áreas de acesso ao logradouro público, de modo a entrar e sair do prédio, sob o controle dos instrumentos apropriados, tais como o uso de coleira e guia e, quando recomendado, da focinheira. O reconhecimento do direito do condômino, ou morador, de criar em sua unidade animais domésticos e com estes circular pelas áreas comuns de acesso às vias públicas não significa que o dono do animal esteja desobrigado de preservar a saúde, o sossego e a segurança dos demais habitantes do prédio. Tampouco significa que tal direito possa ser exercido irrestritamente.
Pengaruh Kombinasi Buah Jeruk Nipis dan Buah Mengkudu Terhadap Mortalitas Pediculus humanus capitis
Authors: Sayekti Fitria Diniah Janah , Qurrohman Muhammad Taufiq , Priyandari Damar Ajeng , Srikandini Chris
Published: August 2020

Head lice (Pediculus humanus capitis) greatly interferes with human activity because it can cause itching of the head, redness and severe infections. The use of natural insecticides is recommended, because natural insecticides are considered safer. Potential anti lice plants are lime and noni. The combination of the two is believed to have a more effective effect on head lice mortality. This study aims to study and determine the effect of a combination of lime juice and noni on the mortality of Pediculus humanus capitis. The concentration of lime and noni which are used are 25%, 50%, 75% and 100%, respectively. The combination of test materials used was 25% limes 75% noni; 50% lime 50% noni; 75% lime and 25% noni, negative control and positive control. The combination of the extract of noni and lime juice had the highest mortality effect on Pediculus humanus capitis with a concentration of 25% combination of lime; 75% noni.
Tracer Study Terhadap Respon Stakeholder untuk Evaluasi dan Pengembangan Kurikulum Program Studi
Authors: Pratiwi Resi , Rahmawati Atik
Published: August 2020

This study aimed to determine the graduate user assessment (stakeholder response). The method used is through a preliminary survey phase of the alumni database, creating a google form tracer study of stakeholder responses, tracking stakeholder responses, distributing tracer study questionnaires and random stakeholder interviews. The research sample is the 2012-2014 class of chemistry graduate users who have been recorded in a tracer study of aspects of alumni tracking. The results of the study show that the assessment of graduates according to stakeholders is integrity (moral and ethics) very good category (63%), professionalism is good (51%), information technology is good (61%), teamwork is good (aspects) 63%), good personal development aspects (63%), good leadership aspects (80%), good foreign language skills (68%), good communication skills (73%), innovation ability and creativity good category (59%), and motivation in working good category (51%).
Konsep Kesejahteraan Perspektif Ashabiyah Ibnu Khaldun Dalam Wisata Religi Tebuireng
Authors: Arfaq Fadlulloh Fakhrudin , Hendratmi Achsania , Ramadhan Dwi Swasana
Published: August 2020

The concept of welfare has developed significantly, but its implementation has not been optimal. One of the concepts of welfare proposed by Ibn Khaldun about circle of equity and the concept of ashabiyah can be a reference. This article aims to analyze the concept of the welfare of Ibn Khaldun's Ashabiyah perspective by taking samples of community research around Tebuireng religious tourism. This research article uses a qualitative approach to the type of case study research. Data collection techniques using direct interviews, documentation and observation. The results of the analysis show that religious tourism in Tebuireng is beneficial to the communities around and within the religious tourism area and the focus of management on religious tourism is the community with synergies between community groups that need to be improved.
Inklusi Sosial Penghayat Kepercayaan; Upaya Mendorong Hak Warga Negara Penganut Kepercayaan Sedulur Sikep Kudus
Authors: Adzkiya Ubbadul , Fadhilah Iman
Published: August 2020

Indonesia has a diversity of religions and cultures, so far many people are still discriminated against because they are different from the state's recognized religion. In Kudus Regency, the Sedulur Sikep community as adherents of Adam's religion could not register their marriage, thus facing population administration problems. This service-based research explains how to strive for them to gain access to public services, social acceptance, and policy changes so that they are not discriminated against again. By connecting perspectives on civil and political rights as well as economic, social and cultural. The results show that the root of the problem which afflicts the victim can be spelled out in this column, namely the administrative system of population causes humiliation on the basis of the belief in participation that impacts on exclusion and other exclusions. To overcome this problem, efforts and strategies that are commonly made are changes at the internal level, empowerment, recognition and acceptance.
Anethum graveolens L‎.

Alleviates Sperm ‎Damage by Limiting Oxidative Stress ‎and Insulin ‎Resistance ‎in ‎Diabetic Rats ‎
Authors: Abbasi-Oshaghi Ebrahim , Khodadadi Iraj , Mirzaei Fatemeh , Ahmadi Mehrdad , Tayebinia Heidar , Goodarzi Mohammad Taghi
Published: August 2020

Background:

It has been reported that diabetes is associated with sperm ‎damage and infertility.

Objective:

The purpose of this experiment was to survey the effect of Anethum graveolens L. (Dill) powder on sperm profiles, oxidative stress, insulin resistance, and histological changes in male diabetic rats.

Methods:

Male rats were randomly divided into 6 groups (n=7); group 1: normal rats, 2: normal rats + 100mg/kg Dill, 3: normal rats + 300mg/kg Dill, 4: diabetic rats, 5: diabetic rats + 100mg/kg Dill, and 6: diabetic rats + 300mg/kg Dill. After 2 months of treatments, the sperm profile, anti-oxidant activity, superoxide dismutase (SOD) activity, and malondialdehyde were measured. The histopathology of testis was evaluated. Hormonal changes and tumor necrosis factor-α (TNF-α) levels were measured by ELISA.

Results:

Total anti-oxidant and SOD activity in diabetic rats significantly decreased, while MDA concentration was significantly increased in the testis and pancreas of diabetic rats compared with control. However, the use of Dill significantly normalized these profiles. The treatment of diabetic rats with Dill changed the sperm parameters. The levels of testosterone, FSH, and LH in diabetic rats were significantly reduced, but the treatment with Dill did not alter the level of these hormones. Dill also significantly normalized testis morphological changes, insulin resistance, and inflammation.

Conclusion:

The use of Dill normalized oxidative stress, inflammation, and insulin resistance in diabetic rats that correlated with sperm profile and testis histological changes. The treatment of diabetic rat models with Dill did not show harmful effects on sperm profiles.
Fibrin-Specific Thrombolytic Therapy for Acute CVA within 6 Hours of Onset, Systematic Review and Meta-analysis
Authors: Alreesi Abdullah , Al Mandhari Amal , Al Raisi Marwan , Al Ruqaishi Huda , Al Abri Fahad , Al Jufaili Mahmood
Published: August 2020

Objective:

Cerebrovascular Accident (CVA) remains a major cause of disability and death and fibrinolytic agents might reduce long-term disability. We sought to determine whether patients receiving fibrin-specific thrombolytic agents acutely (within 6 h) following CVA had improved functional outcome, or decreased mortality or increased intracerebral bleeding at 6-months than patients receiving placebo.

Materials and Methods:

We conducted a systematic review of randomized controlled clinical trials that assessed 6-months functional outcome, mortality and intracranial hemorrhage and compared thrombolytic therapy with placebo in patients randomized within the first 6 hours following CVA. We searched these databases: MEDLINE (1990-2018), Cochrane Central Register of Controlled Trials, and Cochrane Database for Systematic Reviews. Two blinded reviewers reviewed the eligible articles and rated study quality using the Jadad score. We calculated pooled Odds Ratios (ORs) using a random effect model.

Results:

We included 9 studies with 6523 enrolled participants and had 673 deaths. Compared with placebo, thrombolytic therapy within 6 hours of CVA did not result in a statistically significant reduction in 6-month mortality (OR 1.21, 95% confidence interval [CI] 0.94–1.55). More patients in the thrombolytic therapy group had favorable functional outcome (OR 1.20 confidence interval [CI] 1.07–1.35). Thrombolytic therapy caused more fatal intracerebral bleeding than placebo (OR 5.61 confidence interval [CI] 3.40-9.24).

Conclusion:

Fibrin-Specific thrombolytic within 6 hours of CVA improves functional outcome
at the expense of increasing symptomatic and fatal intracerebral bleed. Future studies are required before extending the thrombolytic window to 6-hours.
Nasopharyngeal Carriage of Streptococcus pneumoniae and Associated Factors among Children in Southwest Ethiopia
Authors: Abateneh Dejene Derseh , Shano Abera Kumalo , Dedo Teshale Worku
Published: August 2020

Background:

In Ethiopia, Streptococcus pneumoniae is the predominant causative agent of pneumonia. About, 95% of bacterial pneumonia cases in under five years of children are caused by pneumococci.

Objective:

To assess the nasopharyngeal carriage of Streptococcus pneumoniae, its antibiotic susceptibility pattern, and associated factors among children in Southwest Ethiopia.

Methods:

A cross-sectional study was conducted from October 01, 2018, to December 30, 2018. A total of 293 children aged ≤15 years were included in the study using a systematic random sampling technique. A nasopharyngeal swab was collected using a sterile cotton swab and cultured on blood agar supplemented with 5μg/ml gentamicin. The antimicrobial susceptibility testing was performed using the Kirby-Bauer disc diffusion technique.

Results:

The ages of participants ranged from 5 months to 14 years. The carriage rate of Streptococcus pneumoniae was 74/293 (25.3%). Being within the age group <3 years, the habit of sleeping with parent(s)/guardians and numbers of rooms per household were significantly associated with pneumococcal carriage. Streptococcus pneumoniae showed the highest resistance to Tetracycline, 36 (48.65%), and Trimethoprim/sulfamethoxazole, 29 (39.2%), and was found to be susceptible to Chloramphenicol, 54 (77%), and Erythromycin, 38 (51.4%).

Conclusion:

The nasopharyngeal carriage rate of Streptococcus pneumoniae is considerably high. High antimicrobial resistance of Streptococcus pneumoniae against Tetracycline and Trimethoprim/sulfamethoxazole was observed. Living in a house with a single room, children’s habit of sleeping with parents/guardians and age are associated factors of high pneumococcal carriage. Strategies need to be designed to address the modifiable associated factors and the bacterium antibiotic resistance pattern should be monitored regularly.
Laughter in Combination with Yoga Exercises: Changes in Psychological Distress and Quality of Life in Patients with Coronary Heart Disease (CHD)
Authors: Rouhi Shima , Etemadi Soraya , Pooraghajan Mehrnoosh
Published: August 2020

Background:

Emotional distress (such as depression, anxiety, and stress) predisposes individuals to the risk of heart disease and impact on patient's prospective recovery period. Targeting those factors through psychological intervention can accelerate the healing process. Simulated laughter as a form of therapy in combination with yoga exercise and diaphragmatic breathing exercise may lead to mental and physical relaxation and elevate the quality of life.

Objectives:

This study aimed to measure any psychological distress changes (anxiety, depression, and stress) and simultaneously determine any alterations in the quality of life after intervening laughter-yoga therapy in CHD patients.

Methods:

We conducted an experimental clinical trial which administered a pretest-posttest questionnaire. Also, collected data at a ten-session therapy while patients were referring to the rehabilitation program for their postoperative Coronary artery bypass grafting (CABG) at Tehran Heart Centre. Experimental Participants (N=150) and the control group (N=150) were selected by the convenient sampling method. Subjects participated in 45-minute Laughter Yoga(LY) sessions conducted by an instructor specialised in laughter yoga. A clinical psychologist administered the anxiety, stress, and depression scale (DASS) and Quality of Life Questionnaire (SF-36). We interpreted its eight subscales separately, such as measuring physical function, physical role, physical pain, general health, vitality, emotional role, mental health social function and quality of life.

Results:

Depression in the pretest group was 17.49, which degraded to 4.02 in the posttest; anxiety in the pretest test group was 17.44, which diminished to 4.20 in posttest; also, the mean of stress in the groups showed that in the trial group, the quantity degraded from 16.09 to 3.89. However, those values remained consistent in pre-posttest in the control group. Furthermore, the mean of the quality of life (QoL) in the experimental group was 227.2 in the pretest, which was 605.33 in the posttest, and significantly increased. Accordingly, the impact of laughter-yoga on physical function, physical role, physical pain, general health, vitality, emotional role, mental health, social performance is reported.

Conclusion:

Current research has shown that coronary heart disease (CHD) patients suffer considerably from emotional disturbances (depression, anxiety and stress) accordingly decreased quality of life. Intervening the laughter-yoga treatment by alleviating psychological distress is positively helpful to heal CHD patients. Ultimately, suggestions for further research are offered.
Effect of M-Health Application: “Chicken LOF” (Low Fat in 90 Days) on Lipid Profile and Body Composition Among Dyslipidemia Healthcare Workers: A Randomized Controlled Trial
Authors: Puntpanich Suwadee , Taneepanichskul Surasak
Published: August 2020

Background:

Non-communicable disease has become a public health concern and is associated with an unhealthy lifestyle and aging.

Objective:

This study aimed to explore the effect of M-Health Application: “CHICKEN LOF” on lipid profile and body composition in healthcare workers with dyslipidemia.

Methods:

This study was a randomized controlled trial conducted on 80 full-time healthcare workers having dyslipidemia from Phuket City Hospital. Participants were randomly assigned by a computer generator into an intervention group and control group. The intervention group received “CHICKEN LOF”: M-Health Application and usual care, and the control group received only usual care. Outcomes were measured on days 30, 60, 90 and compared to baseline.

Results:

The mean age was 33.9 years in the intervention group and 33.2 years in the control group. The baseline characteristics were not statistically or significantly different. However, significant changes were observed in intervention group regarding total knowledge (p<0.001), total attitude (p=0.001), total practice (p<0.001), HDL-C (p=0.002), weight (p<0.001), BMI (p=0.001), body fat percentage (p=0.029), bone mass (p=0.030), BMR (p=0.032) and total body water (p=0.027). In pairwise comparison, a significant increase in knowledge, attitude and practice was found from the baseline to day 30, 60 and 90, respectively.

Conclusion:

In the present study, CHICKEN-LOF mobile application was found to be effective in terms of knowledge, attitude and practice, and contributed to improving lipid and body composition. This study suggests a longer term implementation to evaluate sustainability not only in the healthcare setting but also in the community.
Predicting Quality of Life in Chronic Obstructive Pulmonary Disease Patients Living in the Rural Area of Chiang Mai Province, Thailand
Authors: Kantatong Tassawan , Deesomchok Athavudh , Panpanich Ratana , Sungkarat Somporn , Siviroj Penprapa
Published: August 2020

Background:

Chronic Obstructive Pulmonary Disease (COPD) becomes burdensome and reduces the quality of life in COPD patients and their families. Understanding the factors affecting the quality of life could improve the process of care and treatment of these patients. Therefore, this study aimed to investigate the factors that influence and can predict the quality of life in COPD patients.

Methods:

A total of 281 COPD patients were included and analyzed by spirometry measurement, BODE index and its components (body mass index; BMI, forced expiratory volume in one second % predicted; FEV1%predicted, dyspnea score of the modified Medical Research Council; mMRC, and distance in the six-minute walking test; 6MWT).Quality of life was assessed by the St. George’s Respiratory Questionnaire (SGRQ).

Results:

The total SGRQ score was 42.1±17.4. The mMRC dyspnea score, ABCD group classification of COPD and BODE index moderately correlated with the total SGRQ score. Weak correlations were found between BMI, FEV1%predicted and 6MWT. Multiple regression analysis showed that the mMRC dyspnea score, BODE index, age, and COPD group D were important predictors of quality of life in COPD patients with R2 of 0.467.

Conclusion:

The mMRC dyspnea score, BODE index, age, and COPD group D could predict the quality of life in the COPD patients in this study.
Recent Advances in Standardization of Herbal Drugs
Authors: Kamboj Anjoo , Kaur Ishtdeep , Kaur Narinder
Published: August 2020

Background:

Herbal drugs play a significant role to maintain the human healthiness and to treat the ailments since the dawn of civilization. Moreover, these plants have provided many lead compounds that culminated in modern medicine. A single herb is regarded as mini-combinatorial library of phytoconstituents hence the quality control of herbal drugs in an herbal formulation is not an easy task because a number of factors impact their pharmacological efficiency and consistent therapeutic effects. Hence, to provide consistent beneficial therapeutic effects, standardized herbal products of consistent quality and purity are required.

Methods:

This review is based on publications obtained by a selective search in PubMed using the keywords “Standardized herbal products”, “fingerprinting”, “authentication”, “chemometric, hyphenated techniques”, “quality control of herbal drugs”, “identification”.

Results:

In the era of modernization, chromatographic techniques coupled with sophisticated spectroscopic analytical methods are used in estimating the authenticity, identity and characteristic of herbal products. Further, with the advancement of computer technology, chemometrics methods have become a leading tool with an unsupervised pattern recognition technique for handling multivariate data without prior knowledge about the studied samples and mines more beneficial and valuable information about the chemical entities from the raw data.

Conclusion:

Standardization of HDs chromatographic fingerprint is not always a perfect way to present all compounds. To assess the quality of medicinal plants, new ways are regularly being explored such as combination chemical fingerprint with biological methods, biofingerprint and metabolic fingerprint quality metrology, pharmacodynamics and export system of medicinal plants have been researched in some groups but still a significant amount of work is required to achieve a perfect system for quality evaluation of herbal drugs. Further, novel chemometric techniques have been unfolded that mines more beneficial and valuable information about the chemical entities from the raw data. So this review emphasis mainly on hyphenated techniques associated with chemometric method used in herbal drugs for identifying more valuable information and various methods for providing data, among which most commonly used techniques are chemometric resolution method and Principal Component Analysis (PCA) method.
Mass Drug Administration With High-Dose Ivermectin and Dihydroartemisinin-Piperaquine for Malaria Elimination in an Area of Low Transmission With High Coverage of Malaria Control Interventions: Protocol for the MASSIV Cluster Randomized Clinical Trial
Authors: Dabira Edgard Diniba , Soumare Harouna M , Lindsay Steven W , Conteh Bakary , Ceesay Fatima , Bradley John , Kositz Christian , Broekhuizen Henk , Kandeh Balla , Fehr Alexandra E , Nieto-Sanchez Claudia , Ribera Joan Muela , Peeters Grietens Koen , Smit Menno Roderick , Drakeley Chris , Bousema Teun , Achan Jane , D’Alessandro Umberto
Published: August 2020

Background

With a decline in malaria burden, innovative interventions and tools are required to reduce malaria transmission further. Mass drug administration (MDA) of artemisinin-based combination therapy (ACT) has been identified as a potential tool to further reduce malaria transmission, where coverage of vector control interventions is already high. However, the impact is limited in time. Combining an ACT with an endectocide treatment that is able to reduce vector survival, such as ivermectin (IVM), could increase the impact of MDA and offer a new tool to reduce malaria transmission.

Objective

The study objective is to evaluate the impact of MDA with IVM plus dihydroartemisinin-piperaquine (DP) on malaria transmission in an area with high coverage of malaria control interventions.

Methods

The study is a cluster randomized trial in the Upper River Region of The Gambia and included 32 villages (16 control and 16 intervention). A buffer zone of ~2 km was created around all intervention clusters. MDA with IVM plus DP was implemented in all intervention villages and the buffer zones; control villages received standard malaria interventions according to the Gambian National Malaria Control Program plans.

Results

The MDA campaigns were carried out from August to October 2018 for the first year and from July to September 2019 for the second year. Statistical analysis will commence once the database is completed, cleaned, and locked.

Conclusions

This is the first cluster randomized clinical trial of MDA with IVM plus DP. The results will provide evidence on the impact of MDA with IVM plus DP on malaria transmission.

Trial Registration

ClinicalTrials.gov NCT03576313; https://clinicaltrials.gov/ct2/show/NCT03576313

International Registered Report Identifier (IRRID)

DERR1-10.2196/20904
A Framework for a Statistical Characterization of Epidemic Cycles: COVID-19 Case Study (Preprint)
Authors: De Carvalho Eduardo Atem , De Carvalho Rogerio Atem
Published: August 2020

BACKGROUND

Since the beginning of the COVID-19 pandemic, researchers and health authorities have sought to identify the different parameters that drive its local transmission cycles to make better decisions regarding prevention and control measures. Different modeling approaches have been proposed in an attempt to predict the behavior of these local cycles.

OBJECTIVE

This paper presents a framework to characterize the different variables that drive the local, or epidemic, cycles of the COVID-19 pandemic, in order to provide a set of relatively simple, yet efficient, statistical tools to be used by local health authorities to support decision making.

METHODS

Virtually closed cycles were compared to cycles in progress from different locations that present similar patterns in the figures that describe them. With the aim to compare populations of different sizes at different periods of time and locations, the cycles were normalized, allowing an analysis based on the core behavior of the numerical series. A model for the reproduction number was derived from the experimental data, and its performance was presented, including the effect of subnotification (ie, underreporting). A variation of the logistic model was used together with an innovative inventory model to calculate the actual number of infected persons, analyze the incubation period, and determine the actual onset of local epidemic cycles.

RESULTS

The similarities among cycles were demonstrated. A pattern between the cycles studied, which took on a triangular shape, was identified and used to make predictions about the duration of future cycles. Analyses on effective reproduction number (Rt) and subnotification effects for Germany, Italy, and Sweden were presented to show the performance of the framework introduced here. After comparing data from the three countries, it was possible to determine the probable dates of the actual onset of the epidemic cycles for each country, the typical duration of the incubation period for the disease, and the total number of infected persons during each cycle. In general terms, a probable average incubation time of 5 days was found, and the method used here was able to estimate the end of the cycles up to 34 days in advance, while demonstrating that the impact of the subnotification level (ie, error) on the effective reproduction number was <5%.

CONCLUSIONS

It was demonstrated that, with relatively simple mathematical tools, it is possible to obtain a reliable understanding of the behavior of COVID-19 local epidemic cycles, by introducing an integrated framework for identifying cycle patterns and calculating the variables that drive it, namely: the Rt, the subnotification effects on estimations, the most probable actual cycles start dates, the total number of infected, and the most likely incubation period for SARS-CoV-2.
Global Determinants of Covid-19 Deaths: Lockdown Dates and Social Distancing Measures Mattered (Preprint)
Authors: Hooper Vincent
Published: August 2020

UNSTRUCTURED

The severity of this global pandemic and focus upon its devastating effects upon local
communities has tended to be through the media with time series graphics at the national
level. Thus, the purpose of this paper is to examine the cross-national differences in the
deaths caused by covid-19, and relate that to a range of contextual variables.

Objectives: The objective of this paper is to examine the influence that various
contextual variables have upon the number of deaths due to covid-19, across the world.
Setting Level: This study utilizes data for 125 countries for contextual variables from 1st
January 2020 until the 15th June 2020.
Participants: This study considers deaths from covid-19.
Interventions: DELETED
Primary and secondary outcome measures: The contextual variables considered in this
study are stringency index, stringency variability, lockdown date, population density, level
of airline passengers and country health security index.
Results: It is shown there is a very strong association between the level of airline
passengers and covid-19 deaths. The results from regression analysis conducted in this
study show significant positive relationships at the 5% level of statistical significance
between Deaths from covid-19 and airline passenger levels and stringency variability;
significant negative relationships are revealed for stringency index and lockdown date
supporting the notion that lock down and social distancing measures mattered and were
effective. The Global health security index and population density did not significantly
affect deaths.
Conclusion: This study highlights the strong link between a country’s airline passengers
and covid-19 deaths and found that the lockdown date and stringency measures had a
significant effect upon deaths. The implications of the research is that lockdown and
stringency measures implemented by governments around the world worked and
mattered. Further, the fact that global health security did not affect deaths may indicate
better preparedness required to confront future pandemics.
Trial Registration: DELETED

INTERNATIONAL REGISTERED REPORT

RR2-doi.org/10.1101/2020.07.28.20163394
A New Textbook for Pursuing a New Era—Comment on Wu Guodong’s
Authors: Bao Yueli
Published: August 2020

In the new epoch, society is continuously advancing. With the accelerated development of network information dissemination, music education should satisfy the development of the times. Teaching methods should also be contemporary and innovative. With the introduction and development of quality concepts, music education is slowly improving. As a self-governing subject, it should be valued by teachers and students. Mr. Wu Guodong’s “Chinese National Music” concentrates on networked teaching and the “new teacher-training” of the new era. He strives to make more students experience the infinite charm of Chinese national music, build a distinct academic philosophy, and reshape the Chinese national spirit.
A DISCRIMINAÇÃO DO TRABALHO FEMININO A PARTIR DA DIVISÃO SEXUAL DO TRABALHO
Authors: Rosa Vanessa De Castro
Published: August 2020

opresente trabalho objetiva analisar a discriminação do trabalho feminino a partir da divisão social e sexual do trabalho. A primeira trabalhada por Karl Marx indica a divisão do trabalho na sociedade diante da necessidade de se desenhar papeis definidos para a organização e funcionamento do capitalismo, a segunda, definida pela filósofa e historiadora Silvia Federici, avalia a divisão do trabalho segundo critérios de gênero, também necessária a estrutura capitalista. Nesta visão, a discriminação do trabalho feminino não é algo ocasional, nem típico da contemporaneidade, mas inerente ao funcionamento da estrutura capitalista, que relega o trabalho feminino a papeis sociais socialmente e historicamente definidos, porém, justificados biologicamente e moralmente, a fim de acumular sobre a exploração proletária feminina. Neste quadro, às mulheres foram destinados trabalhos domésticos e trabalhos não remunerados, presentes na esfera do trabalho reprodutivo, ao passo que aos homens foram destinados trabalhos para produção de bens destinados ao mercado – trabalho produtivo. Contudo, o trabalho reprodutivo não remunerado das mulheres é indiretamente custeado pelo salário masculino, o que aumenta a exploração do homem trabalhador. A pesquisa é feita através de revisão de literatura, com referencial teórico em Karl Marx e Silvia Federici. E busca conhecer as raízes históricas e conceituais da exploração e discriminação do trabalho feminino a fim de se buscar no futuro possíveis soluções que encarem a real fonte de discriminação do trabalho das mulheres.
DESCARACTERIZANDO A FUNÇÃO SOCIAL DOS SIGNOS DISTINTIVOS COLETIVOS: UMA ANÁLISE DA PRIMEIRA INDICAÇÃO GEOGRÁFICA DE SERVIÇOS
Authors: Andrade Victor Luiz Pereira de , Canavez Luciana Lopes
Published: August 2020

Por muito tempo desconsiderada pela prática jurídica brasileira, indicações geográficas passaram a receber maior atenção do mercado brasileiro a partir do final dos anos 90, com a mudança na legislação que possibilitou o registro pelo Instituto Nacional da Propriedade Industrial, tanto de indicações de procedência como também de denominações de origem. Neste contexto, em 2012 foi concedida a primeira indicação de procedência referente à prestação de serviços, a primeira do gênero no Brasil e única no mundo da qual se possui notícia. Entretanto, com a onda da oficialização de registros de indicações geográficas, diversos entraves passaram a ser observados, sendo de maior relevância a excessiva proximidade entre os institutos de marcas e indicações geográficas, relação na qual a aplicação de princípios dos primeiros tendem a descaracterizar a própria função social dos segundos. Este artigo se propõe então a analisar o contexto em que se insere a proximidade entre os institutos no Direito brasileiro, perpassando a análise de institutos e do próprio registro da indicação de procedência dos serviços do Porto Digital. Foram utilizados os métodos exploratórios bibliográfico e documental, em uma abordagem dedutiva-indutiva de tom dogmático. Esta pesquisa é fruto de apoio da Fundação de Amparo à Pesquisa do Estado de São Paulo.
LIBERDADE RELIGIOSA COMO DIREITO FUNDAMENTAL E DEVER DE NÃO INTERVENÇÃO
Authors: Coelho Edihermes Marques , Abrahão Júnior Weber
Published: August 2020

A liberdade configura-se constitucionalmente como direito fundamental inviolável. Isso decorre do próprio caput do artigo 5º da Constituição de 1988, mas desdobra-se em diversas outras normas constitucionais e infraconstitucionais. Dentre os desdobramentos do direito à liberdade, encontra-se a liberdade de expressão, de pensamentos e de crenças. Entretanto, ao longo da história do Brasil, constantes situações de violações à liberdade religiosa e mesmo discriminações têm ocorrido. Em face do caráter jusfundamental do direito à liberdade religiosa, impõem-se ao Estado o dever de não intervenção, excetuada a intervenção para resguardar tal liberdade.
DESAFIOS DA DEMOCRACIA DIGITAL NA REALIDADE BRASILEIRA: O ACESSO À ESFERA PÚBLICA ONLINE
Authors: Borsio Bataglia Murilo , Farranha Ana Claudia
Published: August 2020

O presente trabalho tem como objetivo relacionar as discussões acerca da teoria democrática com aspectos deliberativos e de instrumentos de democracia digital. Assim, foca-se na utilização de tecnologia de informação e comunicação (TICs)  no intuito de proporcionar a formação de espaços digitais diante de crise de representatividade verificada em pesquisas de opinião as realizadas por institutos como FGV/DAPP. Ao congregar esses elementos teóricos, a princípio tem-se a hipótese de que a internet seria um novo espaço público de deliberação. No entanto, percebem-se variáveis que influenciam no acesso a esse espaço. Com isso, têm-se as seguintes perguntas de pesquisa: considerando que democracia e tecnologia estão imbricadas, quais os desafios existentes nesse meio? Qual a relação entre arenas online, a exclusão digital e consequente legitimidade política? Na tentativa de respondê-las, mune-se das técnicas de revisão bibliográfica acerca das categorias de democracia deliberativa e de democracia digital. Além disso, como forma de traduzir em dados tal debate da inclusão digital e do acesso da população à internet e demais tecnologias, lança-se mão da análise documental, possuindo como materiais: relatório do TCU sobre inclusão digital, pesquisa TIC domicílios e a Estratégia Brasileira para a Transformação Digital (E-Digital). Ao final, levantam-se questionamentos e agendas de pesquisa para futuros aprofundamentos sobre a temática em tela.
USUCAPIÃO EXTRAJUDICIAL: UM NOVO INCREMENTO NA FUNÇÃO SOCIAL DOS CARTÓRIOS
Authors: Oliveira Sobrinho Afonso Soares , Araujo Filho Clarindo Ferreira
Published: August 2020

O artigo aborda a valorização da função social dos cartórios por meio dos instrumentos extrajudiciais que o poder legiferante tem disponibilizado para a sociedade civil. Para tanto, foi realizada uma sucinta revisão do estado da questão das teorias possessórias abraçadas pelo sistema legal pátrio, bem como revistas as diversas espécies e características desse importante instituto de aquisição de propriedade. Potencialmente, a usucapião extrajudicial pode minorar as consequências nefastas causadas pela falta de regularização fundiária, que diminuem a segurança jurídica, dificultam o acesso ao crédito e promovem o aumento do risco e da taxa de juros cobrados nos negócios imobiliários.