bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk factors for post-contrast acute kidney injury in patients sequentially administered iodine- and gadolinium-based contrast media on the same visit to the emergency department: a retrospective study
Authors: Kang Changshin , Han Soo Hyun , Park Jung Soo , Choi Dae Eun
Published: April 2023

Background: This study compares the incidence of post-contrast acute kidney injury (PC-AKI) in patients who received a single administration of iodine-based contrast medium (ICM) with that in patients who received a sequential administration of ICM and gadolinium- based contrast agents (GBCA) in a single visit to an emergency department (ED) to determine the risk factors for PC-AKI. Methods: Patients who received one or more contrast media in the ED from 2016 to 2021 were included in this retrospective study. They were divided into the ICM alone and ICM + GBCA groups, and the incidence of PC-AKI was compared between the groups. The risk factors were assessed using a multivariable analysis after propensity score matching (PSM). Results: Overall, 6,318 patients were analyzed, of whom 139 were in the ICM + GBCA group. The incidence of PC-AKI was significantly higher in the ICM + GBCA group than in the ICM alone group (10.9% vs. 27.3%, p < 0.001). In the multivariable analysis, sequential administration was a risk factor for PC-AKI, and single administration was not (adjusted odds ratio [95% confidence interval] in the 1:1, 2:1, and 3:1 PSM cohorts: 2.38 [1.25–4.55], 2.13 [1.26–3.60], and 2.28 [1.39–3.72], respectively). In subgroup analyses of the ICM + GBCA group, osmolality (1.05 [1.01–1.10]) and estimated glomerular filtration rate (eGFR, 0.93 [0.88–0.98]) were associated with PC-AKI. Conclusion: Compared with a single administration of ICM alone, sequential administration of ICM and GBCA during a single ED visit might be a risk factor for PC-AKI. Osmolality and eGFR might be associated with PC-AKI after sequential administration.
BOOK REVIEW: UNDERSTANDING SECOND LANGUAGE ACQUISITION
Authors: Dey Manna
Published: April 2023

Lourdes Ortega's "Understanding Second Language Acquisition" was first published by Routledge in 2008. Lourdes Ortega is an internationally renowned scholar in the field of second language acquisition and applied linguistics. Her work has been instrumental in advancing our understanding of the learning and acquisition of second languages. Lourdes Ortega’s Understanding Second Language Acquisition is an excellent resource for anyone interested in the study of second language acquisition (SLA). The book provides an in-depth exploration of the key concepts of SLA and offers a comprehensive overview of current research, theories, and approaches. It is a valuable resource for both language educators and students alike.
Points to consider when developing drugs for dry eye syndrome
Authors: Bae Suyoung , Seung Hosun , Oh Ho Jung
Published: April 2023

Changes in both the social environment (e.g., the increased use of electronic media) and the atmospheric environment (e.g., air pollution and dust) have contributed to an increasing incidence of eye disease and an increased need for eye care. Notably, the signs and symptoms of dry eye syndrome can impact the daily quality of life for various age groups, including the elderly, and usually requires active treatment. The symptoms of dry eye syndrome include tear film instability, hyperosmolarity, ocular surface inflammation and damage, and neurosensory abnormalities. As treatments for dry eye are being developed, a standardized guideline is needed to increase the efficiency of drug development and improve the quality of clinical trial data. In this paper, we present general considerations for the pharmaceutical industry and clinical trial investigators designing clinical trials focused on the development of drugs to treat dry eye syndrome.
La noción de rizoma como perspectiva acerca del tránsito de cazadores-recolectores a sociedades agropastoriles en Antofagasta de la Sierra (Catamarca)
Authors: Hocsman Salomon , Babot María del Pilar
Published: April 2023

Se propone abordar la transición de cazadores a sociedades agropastoriles para el caso de Antofagasta de la Sierra, situada en los desiertos de altura de la provincia de Catamarca, desde la noción de rizoma, siguiendo la conceptualización de Deleuze y Guattari (1980a y b, 2002). Se considera particularmente apropiado su empleo porque en el rizoma no hay una estructura lineal sino conexiones múltiples y heterogéneas y, principalmente, no hay un punto de inicio y fin. Un beneficio de su utilización es que se evita una perspectiva teleológica de progreso. Abordar la transición desde el rizoma, además, permite trabajar con escenarios a diferentes escalas que seguramente fueron extremadamente variables, con gente tomando diferentes elecciones sobre cómo desarrollar su vida en los mismos lugares Así, se explora la utilidad del concepto, aplicándolo a distintas situaciones sincrónicas y diacrónicas propias de la configuración del proceso local.
SOCIAL-PSYCHOLOGICAL ADAPTATION OF SYRIAN-ARMENIAN CHILDREN DIFFICULTIES IN PRIMARY SCHOOL EDUCATION PROCESS
Authors: LACHINYAN Lilit , SARGSYAN Ani
Published: April 2023

This article analyzes and reveals the socio-psychological difficulties of adaptation of Syrian-Armenian children during elementary school educational activities. The effectiveness of social-psychological adaptation in the educational process is conditioned not only by the correct choice and application of educational programs, methods, means, but also by the pedagogues who implement the whole systematic educational process. The problem of the adaptation of Syrian-Armenian children in the educational process of primary classes can be called one of the most important problems of the school. It needs extensive research in terms of pedagogy and psychology and practical work in this direction. In order to study and identify the difficulties of adaptation in the educational process of Syrian-Armenian children, we have carried out research and corrective works from previously developed psychological tasks. The positive results of the research can be used to work with Syrian-Armenian children in educational institutions, reducing their social and psychological adjustment problems in the educational process.
Checklist of Hungarian Sphecidae and Apidae species (Hymenoptera, Sphecidae and Apidae)
Authors: Józan Zsolt
Published: April 2023

Checklist of Hungarian sphecoid wasps (Sphecidae) and bees (Apidae). 306 Sphecidae and 704 Apidae species are listed. Species, which were collected 50 years or earlier, treated as extinct species. I have not seen voucher specimen of the following species: Halictus varipes, Halictus carinthiacus, Hylaeus hungaricus, Osmia hybrida, Osmia versicolor, Sphecodes hungaricus, Sphecodes schencki and Sphecodes sareptensis. These species are not listed. Belomicroides fergusoni (Sphecidae), Andrena pyropygia, Halictus cochlearitarsis, Melitta wankowiczi and Osmia scutellaris are first records for Hungary.
Observation of high degree stylopization of European paper wasp – Polistes dominula (Christ, 1791) in Hungary
Authors: Móczár László , Sziráki György
Published: April 2023

Altough the paper wasp Polistes dominula is a well known host of Xenos vesparum in many European countries, in Hungary it was observed in 1993 at first occasion. The documentation of this observation – with illustration by photographs – is performed in present paper. 5 of the 30 examined wasps were stylopized, and these 5 exemplars were parasitized by 18 strepsipteran specimens. Some details of behaviour of the parasite and host insect are discussed also.
Védett növényfajok előfordulási adatai Észak-Somogyban
Authors: Rozner György , Miókovics Eszter , Vidéki Róbert
Published: April 2023

Between 2005-2011, distribution of protected plant species was mapped in the loess hills of Marcali-hát, the marshland of Nagyberek, the southern shorezone of Lake Balaton and Külső-Somogy hills (Somogy county). Altogether, 72 protected and 1 strictly protected species were recorded. 9 species (Menyanthes trifoliata, Ophioglossum vulgatum, Anacamptis pyramidalis, Gymnadenia conopsea, Platanthera bifolia, Linum hirsutum, Aster amellus, Eleocharis uniglumis and Agrostemma githago) are new for the local flora.
Cognitive Flexibility Levels and Self-Efficacy Perceptions of Preservice Teachers
Authors: Kazu Hilal , Pullu Serkan
Published: April 2023

The aim of this study was to examine the correlation between preservice teachers’ cognitive flexibility levels and their teaching self-efficacy perceptions. Convenience sampling was used for the sample group of the study conducted according to the correlational survey model. The sample group consisted of 4th-year students who were studying in the departments of ‘Computer and Instructional Technologies Education’, ‘Classroom Teaching’, ‘Art Teaching’, ‘Mathematics Teaching’, ‘Turkish Teaching’, ‘Social Studies Teaching’, ‘Preschool Teaching’, and ‘Science Education’, under the body of Faculty of Education, Fırat University during the 2019–2020 academic year. The “Cognitive Flexibility Scale”, which was developed by Martin and Rubin (1995) and adapted into Turkish by Çelikkaleli (2014), and “Teachers’ Sense of Efficacy Scale,” which was developed by Tschannen-Moran and Woolfolk Hoy (2001) and adapted into Turkish by Çapa, Çakıroğlu and Sarıkaya (2005), were used as data collection tools in the study. The data were analysed using a computer-aided statistical program. Kolmogorov-Smirnov test was applied to meet the normality assumption of the data. Since the data met the assumption of normality, independent samples t-test was used to compare student views according to the variable of gender. Analysis of variance was used to make comparison based on the variables of department, grade point average and expectation to pass PPSE (Public Personnel Selection Examination). Pearson’s correlation coefficients were used to determine the correlation between the scales. As a result of the study, both the cognitive flexibility levels and the levels of teaching self-efficacy perception were found to be high in preservice teachers. While the cognitive flexibility level of female preservice teachers was higher than male preservice teachers, the cognitive flexibility levels and teaching self-efficacy perceptions were higher than others in preservice teachers having a high grade point average and a high expectation to pass PPSE. Finally, it was determined that levels of cognitive flexibility and teaching self-efficacy perception affected one another positively and significantly.
Mothers’ Voices on Autism Spectrum Disorder: Leaning Towards Sustainable Inclusive Education in Maragusan, Philippines
Authors: Catubigan Robie V.
Published: April 2023

The birth of a child is the beginning of a woman’s motherhood. It is genuinely illuminated in her raising and rearing responsibilities. This study explores the understanding and experiences of Mansaka mothers about autism before and after diagnosis. This qualitative phenomenological inquiry employed face-to-face semi-structured interviews with five Mansaka mothers in the countryside of Maragusan having a child diagnosed with Autism Spectrum Disorder. Colaizzi’s method was applied to analyze the data through transcribing, coding, and theming. The result of the study revealed that mothers have personal observations about their children’s behavior and share their rearing issues, retrospection, and standpoint of their children’s condition before diagnosis. It was highlighted in the result that parents had different reactions, realizations, and responses about their children’s condition after the diagnosis. The implication of the study infers development of sustainable inclusive practices and reviews of policy.
Removal of Zinc Ions from Aqueous Solutions with the Use of Lignin and Biomass Part II
Authors: Miros-Kudra P. , Sobczak P. , Gzyra-Jagieła K. , Ciepliński M.
Published: April 2023

In response to the trend toward sustainable management of by-products from the pulp and paper industry as well as plant waste, practical and economical methods are being developed to use them in a way that does not pose a threat to the environment. The main aim of the research was to study the possibility of using lignin and plant biomass as biosorbents for the removal of zinc ions from aqueous solutions. The secondary aim was to build an optimal multilayer system made of biosorbents selected during the research in order to obtain the highest sorption efficiency and to determine the best conditions of the sorption process. The effectiveness of zinc ion sorption was assessed using an appropriate combination of sorbents such as lignin, oat bran, rice husk, chitosan, pectin, sodium alginate, pine bark, coconut fiber and activated carbon, selected on the basis of literature data and the preliminary results of tests carried out using FTIR and AAS. The main component of the sorption system was lignin separated from black liquor. Results indicate that the best Zn sorption system was based on coconut fiber, lignin, and pine bark, for which the maximum sorption efficiency was 95%. The research also showed that the increase in the process temperature, the mass of biosorbents used and the alkaline pH are the factors that increase the efficiency of the sorption. It can be concluded that lignin and plant biomass can be used as ecological sorbents of zinc ions from water solutions. They are safe for the environment, produced from renewable sources, and are by-products or waste materials, which is part of the sustainable development and circular economy currently promoted in the EU.
Implications Regarding the Logistical Integration of Exoskeleton-Type Robotic Systems
Authors: Minculete Gheorghe , Virca Ioan , Giurgiu Tiberiu
Published: April 2023

The technological developments of the 2nd decade of the 21st century reveal the development of systems that facilitate economic operations within the economic and military supply chains to immediately meet the needs of consumption and use. Therefore, one of the technological systems with an important impact on the efficiency of carrying out specific operations in such systems is represented by the exoskeleton robotic system. This material approaches in a correlative manner the importance and role of exoskeleton-type robotic devices starting from the increased demands of the Future Soldier both on the operational line and in terms of adequate logistic support for its sustainment and self-sustainment. Therefore, even in the military logistics of the constitution combat forces of tactical and/or joint level, exoskeleton-type devices are used by military and civilian workers especially for carrying out activities appropriate to the loading and unloading of materials, in order to quickly respond to the requests for the timely granting of the complex logistical support both during the day, as well as at night. Moreover, this exoskeleton-type system can be easily used by logistics execution personnel who may also work in different areas of logistic support such as maintenance, movement and transportation, or medical support.
Prevention and treatment of wound infections after caesarean section
Authors: Krylov K. Yu. , Rukhliada N. N. , Biryukova E. I. , Tsechoeva L. Sh.
Published: April 2023

Caesarean section (cS) is one of the most common obstetric operations in the world. About 32 % of all births end by caesarean section. Postpartum infection at the surgical site, wound infection and endometritis are the main causes of long stays in maternity hospitals and are a source of additional costs for the healthcare system. In 2–16 % of cases postpartum endometritis develops. Many risk factors for the development of postpartum infections have been described. These include maternal factors (such as tobacco use, inadequate prenatal care, obesity, corticosteroid use; prematurity, multiple gestation, and uterine scar), intrapartum and operative factors (such as chorioamnionitis; premature rupture of membranes; prolonged anhydrous period; prolonged labor , especially a long second period; large incision of the anterior abdominal wall; subcutaneous tissue thickness more than 3 cm; subcutaneous hematoma; lack of antibiotic prophylaxis; rapid labor; massive blood loss during childbirth). Effective measures to reduce the incidence of obstetric infectious complications include prophylactic use of antibiotics (preoperative preparation with first-generation cephalosporins and intravenous azithromycin), preoperative showering with chlorhexidine instead of iodine, shaving immediately before surgery, vaginal sanitation, removal of the placenta by traction of the umbilical cord, suturing of the subcutane-ous tissue, if the depth of the wound is larger than 2 cm and suturing the skin with sutures instead of using staples. Establishing an evidence-based optimal care algorithm for patients after caesarean section can reduce the incidence of serious infectious complications.
The value of various etiopathogens in the development of infectious complications after cardiac surgery with sternal access
Authors: Kasatov A. V. , Gorowitz E. S.
Published: April 2023

The literature data on the role of various microorganisms in the etiology of infectious and inflammatory complications in poststernotomic cardiac surgery are discussed. Their pathogens can be a wide range of gram-positive and gram-negative microorganisms, representatives of various taxa. Gram-positive bacteria dominate, in particular bacteria of the genus Staphylococcus. S. aureus and S. epidermidis cause up to 60–70 % of all infectious and inflammatory complications, and S. aureus strains, as a rule, cause more severe clinical forms of the disease (sternomediastinitis). Enterobacteriaceae and non-fermenting group are the predominant gram-negative bacteria. Among non-fermenting bacteria, P. aeruginosa more often cause the development of sternomediastinitis. In recent years, antibiotic-resistant strains, methicillin-resistant staphylococci and gram-negative bacteria producing betalactamases have increasingly become etiopathogens.
Academician Vladimir Ivanovich Burakovsky (1922–1994) (on the 100th anniversary of his birth)
Authors: Kurygin A. A. , Semenov V. V.
Published: April 2023

Professor Vladimir Ivanovich Burakovsky was born on August 20, 1922 in Tiflis (Tbilisi). In 1940, Vladimir entered the Tbilisi Medical Institute. In 1947, V. I. Burakovsky was enrolled in a clinical residency at the Department of Faculty Surgery № 2 (since 1955 – Department of Surgery for Advanced Doctors № 1) Military Medical Academy named after S. M. Kirov in Leningrad. In the spring of 1960, Vladimir Ivanovich was accepted as a senior researcher at this Institute and appointed the head of the Department of Surgery of the heart and blood vessels in children. Vladimir Ivanovich was the author and co-author of more than 500 scientific papers, including 15 monographs: on the issues of pathophysiology, clinic, diagnosis and surgical treatment of congenital and acquired heart defects and major vessels, heart diseases in young children, complications after open heart surgery, surgery of complex congenital defects and coronary heart disease, heart defects with pulmonary hypertension, the use of hyperbaric oxygenation in cardiac surgery, surgical treatment of coronary disease, heart transplantation in experiment, history and philosophy of cardiac surgery. In 1970, «for the best scientific work on thoracic surgery», Vladimir Ivanovich was awarded the title of laureate of the S. I. Spasokukotsky Prize of the USSR Academy of Medical Sciences (together with B. A. Konstantinov). Academician Vladimir Ivanovich Burakovsky died on September 22, 1994 in Moscow and was buried at the Kuntsevo cemetery. The Institute of cardiac Surgery of the Federal State Budgetary Institution «A.N. Bakulev National Medical Research center of cardiovascular Surgery» (A. N. Bakulev NMRcVS) of the Ministry of Health of the Russian Federation bears his name, in which a bust of his creator is installed.
Environmental valuation of hydro-environmental services of the Tropical Montane Cloud Forest
Authors: Jimenez Palacios Arturo , Romero-López Rabindranarth
Published: April 2023

Environmental externalities are just one class of externalities (or external effects). They are not more important than any other type of economic externalities, but it would not be possible to find rational arguments to justify that they are less so. If more complex and therefore better decisions are to be taken, these externalities should be duly quantified and incorporated in the framework of an economic analysis of public or private decisions of society. In that case, they can be accounted for as costs of our decisions. Environmental economics has different environmental valuation methods to include ecosystems and its dynamics into an economic system. The most applied methods are contingent valuation, hedonic prices, and travel cost. These methods may be used as a guide to formulate public policies to protect the environment and have an efficient management. The present research is an analysis for hydro-environmental services (recreational services) of the tropical montane cloud forest (La Granada waterfall) of Coatepec due to the increasing risks caused by human activity. Therefore, the travel cost method will be applied to estimate the economic value associated with the ecosystem. This method applies conventional empirical techniques used by economists to estimate economic values based on market prices. The findings showed different travel costs for every chosen zone and a consumer surplus of $47.10 MXN and an estimated yearly value of $70,645 MXN.
Ixtlamatilistli wan tepahtilistli ipan Ixhuatlán tlen Madero, Veracruz
Authors: Nava Vite Rafael , Nava Hernández Yoltzi
Published: April 2023

Ika ni tlahkuilolistli tihnekih tihnextiseh kenihki masewalmeh mopahtiah ika xiwipahtli kemah kipiyah kokolistli ipan inintlakayo tlen tlasehsehkayotl wan tlatotonihkayotl. Nohkia, kihnextia kenihki tepahtiyanih tlen chanchiwah ipan chinankomeh nawas wan ñuhus tlen Ixhuatlán tlen Madero, Veracruz, tlen wextekapan tlalli, keniki kinchikoittah wan kintepotztokah pampa kinkokoliah. Ixhuatlán tlen Madero, Veracruz, eli se municipio tlen kipiya miakeh tlahtolmeh, pampa nikan itztokeh ipan chinankomeh nawatinih, tepehuas, totonakos wan otomimeh. Miak ohtinih tlen kipiya san tlawel owih se nehnemis pampa san kipiya tepisilli. Ni tlahkuilolistli motlatzkilia ipan se tekitl tlen mochihki ipan 2010 wan tlanki ipan 2012, ni tekitl mochihki ipan chinankomeh Guayabo, Cacahuatengo wan Ahuacapa ome, tlen Ixhuatlán tlen Madero, Veracruz. Keman titekipanokeh ipan ni chinankomeh, timokamawihkeh ika tepahtiyanih wan ipan ni tlahkuilolistli tihnextiah tlatzintokilli tle tihchihkeh.
 
Este artículo tiene por objetivo hacer visible las diversas prácticas curativas que tienen como base el uso de plantas medicinales que pueden curar las enfermedades causadas por un desequilibrio de la composición frío-caliente del cuerpo. Asimismo, hace evidente una situación de persecución que han vivido los médicos tradicionales de comunidades nahuas y otomíes del municipio de Ixhuatlán de Madero, Veracruz, ubicadas en la Huasteca baja de Veracruz.
Ixhuatlán de Madero, Veracruz es un municipio con una rica diversidad lingüística y cultural ya que en dicho municipio comparten el territorio los grupos lingüísticos nahuas, lhimasipij (tepehuas), totonacas y ñuhus (otomíes). En esta región se viven condiciones de alta marginación y la mayoría de los caminos que dan acceso a las comunidades son de terracería y de dificil acceso.
El presente artículo se sustenta en un trabajo de campo llevado a cabo del 2010 al 2012 en las comunidades nahuas de El Guayabo, Cacahuatengo y Ahuacapa Segundo de Ixhuatlán de Madero, Veracruz. En la actividad de campo se entrevistaron a varios médicos tradicionales que permiten visibilizar las condiciones de atención a la salud de la población nahua.
Estilos de vida saludable en el contexto de la contingencia por COVID-19 en adultos jóvenes veracruzanos durante el año 2022
Authors: Beltrán-Guerra León Felipe , Arellanez-Hernández Jorge Luis , Ortega-Herrera María Erika
Published: April 2023

Derivado del estudio Ansiedad, depresión, estilos de vida y bienestar en el contexto sociocultural actual, realizado en el año 2022, se presentan los resultados de la variable Estilos de Vida. El estudio da continuidad a los datos obtenidos en los años 2020 y 2021, donde las medidas de confinamiento y distanciamiento social implementadas en el contexto de la pandemia por COVID-19 trajeron cambios en los estilos de vida de la población. Se muestran los resultados de los Estilos de Vida en dos momentos del 2022: marzo con 694 personas y octubre con 367 participantes. Los resultados muestran incremento en las diferentes áreas de los estilos de vida, mismos que reflejan comportamientos adaptativos ante la pandemia. Por las características del estudio los datos no pueden ser generalizables; sin embargo, pueden ser utilizados como referente para el desarrollo de estrategias de atención a los estilos de vida saludables y bienestar.
Healthy lifestyles in the context of the COVID-19 contingency in young adults from Veracruz during the year 2022. Measurement first and second semester
Abstract: Based on the study "Anxiety, Depression, Lifestyles, and Well-being in the Current Sociocultural Context" conducted in 2022, the study presents the results of the Lifestyles variable. The study builds on data obtained in 2020 and 2021, when confinement and social distancing measures implemented in response to the COVID-19 pandemic led to changes in the lifestyles of the population. Data collection took place twice a year: in March with 694 participants (66.9% women and 33.1% men), and in October with 367 participants (67% women and 33% men). The results indicate an increase in different areas of lifestyles, suggesting the possible presence of adaptive behaviors. Although the study's characteristics do not permit generalization of the data, it is possible to use the findings as a reference for developing strategies for promoting healthy lifestyles and well-being.
A IMPORTÂNCIA DA BIBLIOTECA NA EDUCAÇÃO INFANTIL: ESTUDO DOCUMENTAL EM ESCOLA DA REDE PRIVADA DE ENSINO EM GOIÂNIA
Authors: Santos Josué Pereira da Silva , Dos Santos Andrea Pereira
Published: April 2023

Apresenta contribuições da biblioteca para a pesquisa e desenvolvimento escolar nos anos pré-escolares. Tem como objetivo geral verificar aspectos da contribuição da biblioteca para o desenvolvimento da aprendizagem e pesquisa escolar na educação infantil de uma escola confessional privada de Goiânia. Identifica parcialmente, características e abrangência da biblioteca, do profissional e das ações que favorecem a informação e a investigação científica no Projeto Político Pedagógico e em documentos institucionais. Conceitua biblioteca escolar, letramento informacional e Projeto Político Pedagógico. Os procedimentos metodológicos desta pesquisa são classificados quanto à finalidade, sendo categorizado como pesquisa básica e quanto aos propósitos, utilizando-se do modelo de pesquisa exploratória a fim de identificar através de coleta de dados documentais e levantamento bibliográfico, conceitos que integram o Letramento Informacional, a biblioteca escolar, o profissional bibliotecário e, métodos de aprendizagem para o público entre 1 e 5 anos de idade. Realiza discussão teórica a partir de documentos institucionais da escola confessional privada de Goiânia. Aponta métodos de aplicação de letramento informacional na educação infantil. Conclui que o Projeto Político Pedagógico da escola estudada atinge de forma parcial a importância da biblioteca e do bibliotecário para o desenvolvimento do ensino-aprendizagem e que o bibliotecário deve contribuir para a maior visibilidade das ações e projetos que compete à profissão e ao ambiente, agregando na formação pedagógica escolar. O período de execução desta pesquisa se deu entre abril e julho de 2018.
CRIMINOLOGIA DO PRECONCEITO: UMA PERSPECTIVA HISTÓRICO-LEGISLATIVA DO BRASIL COLÔNIA À PRÉ-ABOLIÇÃO DA ESCRAVATURA
Authors: Das Neves Cleuler Barbosa , Matos Gisele Gomes
Published: April 2023

A partir da questão racial do caso brasileiro de 300 anos de escravidão legalmente amparada, no presente artigo, recorrendo ao método dialético-argumentativo, articula uma análise sob as perspectivas histórica e legal das questões atinentes à inserção do discurso racista na legislação brasileira, que culminou, inclusive, na adoção de uma política de branqueamento do país, apresentando-se o arcabouço legislativo desde a aplicação das Ordenações do Reino e a Constituição Imperial de 1824 perpassando por Leis como o Código Criminal do Império, a Lei de Terras, A Lei Diogo Feijó, a Lei do Sexagenário, a Lei Afonso Arinos, dentre outras até o período pré-abolição da escravatura e pré-república, atrelado à realidade social da época, recorrendo-se à Criminologia como ferramenta teórica.
Analysis of Protein Markers in Plasma of Patients with Drug Dependence Syndrome: Observational Clinical Study
Authors: Bykov I. M. , Lubchenko D. A. , Popov K. A. , Stolyarova A. N. , Popova M. A. , Tsymbalov O. V. , Esaulenko E. E.
Published: April 2023

Background. In drug addiction treatment, the diagnostic process is based on the chemical toxicological determination of the intoxication substrate or its metabolite. Laboratory monitoring and prediction issues that could form the basis of secondary prevention remain unresolved. Specific nervous tissue proteins are considered to be the most promising laboratory markers of drug pathology.

Objective — to determine some potential biomarkers of protein-chemical nature in the plasma of patients with drug dependence syndrome.

Methods. The study was conducted according to the design of an observational clinical trial at the Narcological Dispensary of Krasnodar Krai in the period from 07.2021 to 07.2022. The main group (group 2) included 31 patients diagnosed with substance dependence syndrome. The control group (group 1, n = 15) consisted of healthy subjects submitted to occupational medical examinations. During the detoxification-stabilization therapy and rehabilitation, 5 proteins were determined in the plasma: brainand glial-derived neurotrophic factors, neuron-specific enolase, alpha-synuclein and calcium-binding protein S100B. Statistical analysis of the data involved the Mann-Whitney test for comparing the values of the control and experimental groups and the Wilcoxon test for comparing the values of one group obtained at different stages of observation. The calculations were carried out using StatPlus version 7 (AnalystSoft Inc., USA).

Results. A total of 31 patients were included in the main group, 18 of them were followed up with a diagnosis of opioid dependence syndrome (n = 11) or psychostimulant dependence syndrome (n = 7). Patients dropped out of the study due to their refusal to participate in the study or undergo rehabilitation, or due to relapse of the disease. When admitted to the hospital, patients indicated a 45% decrease in brain-derived neurotrophic factor in the plasma ( p < 0.001), and a 3.9-fold decrease after rehabilitation course ( p < 0.001). Glial-derived neurotrophic factor in the plasma exceeded the controls 1.9 times ( p < 0.001) upon admission to hospital, but rapidly returned to normal values thereafter. Level of neuron-specific enolase in the plasma was also poor, 36% lower than the controls ( p <0.001), but approached the control values by the end of rehabilitation.

Conclusion. The study obtained data indicating the changes in neurotrophic factors in the blood plasma of patients with opioid or psychostimulant dependence. The rehabilitation period was marked by a relatively rapid improving level of neurotrophins; however, brain-derived neurotrophic factor remained reduced despite the successful treatment, which may indicate the irreversible changes.
Cold Ion-Molecule Chemistry: The Very Different Reactions of He+ with CO and NO
Authors: B. V. Martins Fernanda , Zhelyazkova Valentina , Osterwalder Andreas , Merkt Frédéric
Published: April 2023

The ion-molecule reactions He+ + CO → He + C+ + O and He+ + NO → He + N+ + O have been measured at collision energies between 0 and kB · 10 K. Strong variations of the rate coefficients are observed below kB · 5 K. The rate of the He+ + CO reaction decreases by ~30% whereas that of the He+ + NO reaction increases by a factor of ~1.5. These observations are interpreted in the realm of an adiabatic-channel capture model as arising from interactions between the ion charge and the dipole and quadrupole moments of CO and NO. We show that the different low-energy behavior of these reactions originates from the closed- vs. open-shell electronic structures of CO and NO.
Molecular Complexity for Chemical Reactions
Authors: Von Korff Modest , Sander Thomas
Published: April 2023

A new method is presented on how to calculate molecular complexity for chemical reactions by the fractal dimension of educts and products. Two pathways for the total synthesis of strychnine were compared. Significant differences in the two synthesis pathways were reflected by reaction complexity. These results demonstrate that reaction complexity is a powerful measure to group chemical reactions beyond substructural changes.
RESULTS OF THE FIRST SATURATION OF TOBACCO VARIETIES OF AN INTERSPECIFIC HYBRID WITH GENES OF THE AUSTALIAN WILD SPECIES NICOTIANA ROSULATA DOMIN
Authors: Ларькина Н.И.
Published: April 2023

Виды рода Nicotiana являются идеальным модельным объектом для проведения исследований в разнообразных биологических направлениях. Дикий австралийский вид Nicotiana rosulata Domin использовали для создания фертильного межвидового гибрида Дюбек 44 х N. rosulata и на его основе получили при первом насыщении сортом Иммунный 580 новый гибрид с двумя геномами N. tabacum и одним геномом дикого вида. Изучали методы его создания и генетические признаки жизнедеятельности. Выяснено, что от самоопыления гибрид не дает семена.

Species of the genus Nicotiana are an ideal model object for conducting research in various biological directions. The wild Australian species N. rosulata was used to create a fertile interspecific hybrid Dubeck 44 x N. rosulata and based on it, a new hybrid with two genomes of N. tabacum and one genome of a wild species was obtained at the first saturation with the Immune 580 variety. Methods of its creation and genetic signs of vital activity were studied. It was found out that the hybrid does not produce seeds from self-pollination.
THE EFFECT OF CORONAVIRUS INFECTION ON THE SPECIES DIVERSITY OF THE INTESTINAL MICROBIOTA
Authors: Назарова М.В. , Потатуркина-Нестерова Н.И.
Published: April 2023

Приведены результаты оценки изменений микробиоты кишечника больных коронавирусной инфекцией при помощи показателя индекса разнообразия Шеннона-Вейнера. Установлено расширение видового спектра условно-патогенных и патогенных представителей микробиоты на фоне сокращения облигатных видов. Выявлены различия показателя видового разнообразия среди возрастных групп обследованных.

The results of the assessment of changes in the intestinal microbiota of patients with coronavirus infection using the Shannon-Weiner diversity index are presented. The expansion of the species spectrum of conditionally pathogenic and pathogenic representatives of the microbiota against the background of the reduction of obligate species has been established. Differences in the indicator of species diversity among the age groups of the surveyed were revealed.
BIOCHEMICAL FEATURES OF WILD FORMS MEDICAGO VARIA MART. VARIOUS ENVIRONMENTAL ORIGIN IN THE INTRODUCTION OF CULTURE
Authors: Каттабоева Г.С. , Саматова Ш.А. , Думачева Е.В. , Сайфутдинова Л.Д.
Published: April 2023

Изучали биохимический состав дикорастущих форм люцерны изменчивой (Medicago varia Mart.), отобранных из популяций пойм малых рек и меловых склонов юга Среднерусской возвышенности. Особи были пересажены в условия культуры. В среднем, в зеленой массе люцерны пойменного происхождения содержание сухого вещества на 26,4 % превышает показатель у форм мелового происхождения, сырого протеина – на 24,1 %; сырого жира – на 80,9 %; БЭВ – на 8,9 %; сырой золы – на 20,3 %. При этом у особей мелового происхождения на 16,6 % увеличивается количество сырой клетчатки. Полученные данные важны для изучения биологических ресурсов дикорастущих форм M. varia различного экологического происхождения для селекционной работы.

We studied the biochemical composition of the wild forms of alfalfa (M. varia Mart.), selected from the populations of the floodplains of small rivers and chalk slopes of the south of the Central Russian Upland. Individuals were transplanted into cultural conditions. On average, in the green mass of alfalfa of floodplain origin, the content of dry matter is 26,4 % higher than the indicator in forms of chalk origin, raw protein by 24,1 %; raw fat – by 80,9 %; carbohydrates – by 8,9 %; raw ash – by 20,3 %. At the same time, in individuals of chalk origin, the amount of raw fiber is increased by 16,6 %. The resulting data is important for studying the biological resources of wild forms of M. varia various environmental origin for breeding work.
DISEASES, PESTS AND PREDATORS OF FRUIT-EATERS WHICH DAMAGE THE ORCHARDS OF THE WESTERN REGION OF AZERBAIJAN
Authors: Мустафаева Э.Ф.
Published: April 2023

Одним из важнейших вопросов современности является проведение эффективных мероприятий по борьбе с вредителями, в том числе биологической борьбы, в повышении продуктивности садов и улучшении качества плодов.

One of the most important issues of the day is the implementation of effective pest control measures, including biological control, in increasing the productivity of orchards and improving the quality of fruits.
SYNONYMOUS LINGUISTIC BORROWINGS IN MODERN GERMAN LANGUAGE AND THE SOURCES OF THEIR FORMATION
Authors: Терехова Е.В. , Озерова М.Н.
Published: April 2023

Статья посвящена подробному анализу заимствованных в современный немецкий язык элементов английского языка, источников их возникновения, а также пополнения синонимических рядов немецкого языка – явления синонимии, возникающей вследствие заимствования лексем. Особый интерес представляет вопрос целесообразности применения заимствованных единиц на фоне иных автохтонных синонимичных инвариантов.

The article is devoted to the thorough analysis of the English elements borrowed into the modern German language, the sources of their formation, as well as their function of expanding the synonymic rows of the German language - the phenomenon of synonymy, which arises as a result of lexeme borrowing. Special interest is given to the question concerning the relevance of using borrowed units against any other purely German synonymic invariants.
Lipophilic modification of Salirasib modulate the antiproliferative and antimigratory activity.
Authors: Ballari María Sol , Porta Exequiel O. J. , Arel Zalazar Evelyn , Borini Etichetti Carla M. , Padrón José M. , Girardini Javier , Labadie Guillermo R.
Published: April 2023

Salirasib, or farnesylthiosalicylic acid (FTS), is a salicylic acid derivative with demonstrated antineoplastic activity. While designed as a competitor of the substrate S-farnesyl cysteine on Ras, it is a potent competitive inhibitor of isoprenylcysteine carboxymethyl transferase. Although different salirasib derivatives have been reported, the isoprenyl tail has not been modified. In this study, we used a series of synthetic salirasib analogues with lipophilic thioether modifications, including those with or without a 1,2,3-triazole linker, and tested their antiproliferative activity against six different solid tumor cell lines. We carried out a combination of bioassay, cheminformatics, and in silico ADME-Tox to identify new potent analogues. SAR analysis revealed structural and physicochemical features that enhance antiproliferative activity. Analogues with three or more isoprene units or a long aliphatic chain exhibited the most potent activity. Furthermore, we identified three compounds with superior antiproliferative activity than salirasib and similar potency compared to control anticancer drugs across all tested solid tumor cell lines. In addition, the behaviour of the collection on migration and invasion, the key processes in tumor metastasis, were also studied. Three analogs with specific antimigratory activity were identified with differential structural features. The combination of the antiproliferative and antimigratory results prompts to propose that the modification on the thiol aliphatic/prenyl substituents can modulate the activity. Our findings provide valuable insight on the lipophilic salirasib analogues with enhanced antiproliferative activity against solid tumor cell lines. Also, we have been able to identify analogues with specific antimigratory activity that could be the starting points on the development of new antimetastatic agents.
A Robust Framework for Generating Adsorption Isotherms to Screen Materials for Carbon Capture
Authors: Moubarak Elias , Moosavi Seyed Mohamad , Charalambous Charithea , Garcia Susana , Smit Berend
Published: April 2023

To rank the performance of materials for a given carbon capture process, we rely on pure component isotherms from which we predict the mixture isotherms. For screening a large number of materials we also increasingly rely on isotherms predicted from molecular simulations. In particular, for such screening studies, it is important that the procedures to generate the data are accurate, reliable, and robust. In this work, we develop an efficient and automated workflow for a meticulous sampling of pure component isotherms. The workflow was tested on a set of metal-organic frameworks (MOFs) and proved to be reliable given different guest molecules. We show that the coupling of our workflow with the Clausius-Clapeyron relation saves CPU time, yet enables us to accurately predict pure component isotherms at the temperatures of interest, starting from a reference isotherm at a given temperature. We also show that one can accurately predict the CO2 and N2 mixture isotherms using Ideal Adsorbed Solution Theory (IAST). In particular, we show that IAST is a more reliable numerical tool to predict binary adsorption uptakes for a range of pressures, temperatures, and compositions, as it does not rely on the fitting of experimental data, which typically needs to be done with analytical models such as dual-site Langmuir (DSL). This makes IAST a more suitable and general technique to bridge the gap between adsorption (raw) data and process modelling. To demonstrate this point, we show that the ranking of materials, for a standard 3-step Temperature Swing Adsorption (TSA) process, can be significantly different depending on the thermodynamic method used to predict binary adsorption data. We show that for the design of processes that capture CO2 from low concentration (0.4%) streams, the commonly used methodology to predict mixture isotherms incorrectly assigns up to 33% of the materials as top-performing.
Oxa-TriQuinoline: A New Entry to Aza-Oxa-Crown Architectures
Authors: Kumagai Naoya , Kobayashi Toi
Published: April 2023

A new 15-membered-macrocyclic molecular entity, oxa-TriQuinoline (o-TQ), was designed and synthesized. In o-TQ, three oxygen atoms were joined onto three quinoline units at the 2- and 8-positions in a head-to-tail fashion via three-fold SNAr reactions, giving rise to the characteristic N3O3 aza-oxa-crown architecture. o-TQ can serve as a new tridentate nitrogen ligand to capture a Cu(I) cation and adopt a bowl shape, before supramolecular complexation with corannulene and [12]CPP occurs via π–π and CH–π interactions. In the presence of the Cu(I) cation, the non-emissive o-TQ becomes a highly emissive material in the solid state, whereby the emission wave-lengths depend on the ancillary ligand on the Cu(I) cation. The o-TQ/Cu(I) complex is able to promote carbene catalysis to provide a range of enamines with a gem-difluorinated terminus.
Multiplexed deconvolution of enzyme function in a PLP-dependent protein family
Authors: Zmich Anna , Perkins Lydia , Bingman Craig , Acheson Justin , Buller Andrew
Published: April 2023

Sequence-based functional annotation of enzymes is an essential step in the discovery and development of new biocatalysts. The vinylglycine ketimine (VGK) subfamily of pyridoxal-phosphate dependent enzymes plays critical roles in sulfur metabolism and is home to a growing range of secondary metabolic enzymes that synthesize noncanonical amino acids. However, discovery of useful new enzymes has been slowed because functional assignments within the VGK sub-family are convoluted by pervasive mis-annotation. Here, we used a whole-cell substrate multiplexed screening approach to rapidly measure catalytic activities of 40 homologs in the VGK subfamily. This strategy gives direct information on enzyme specificity without having to purify each enzyme or measure individual kinetic constants. We identified a thermostable cystathionine γ-lyase from Thermobifida fusca and performed mechanistic and structural studies. For biocatalytic applications, we identified a well-behaved, thermostable, and promiscuous amino acid γ-synthase from Caldicellulosiruptor hydrothermalis (CahyGS). We showed CahyGS can catalyze a stereoselective γ-addition into L-allylglycine, providing preparative-scale access to a unique set of γ-branched amino acids. High resolution crystal structures of CahyGS show an open-closed transition associated with ligand binding and provide a basis for subsequent engineering. Together, these data show how multiplexed screening approaches aid in the rapid deconvolution of enzyme function and identify enzymes with useful properties for enzymology and biocatalysis.
Possibilities of non-invasive diagnosis of fibrotic phenotype of interstitial lung diseases
Authors: Shchepikhin Evgeniy I. , Shmelev Evgene I. , Ergeshov Atadzhan E. , Zaytseva Anna S. , Shergina Elena A. , Adamovskaya Evgeniy  N.
Published: April 2023

Progressive pulmonary fibrosis is a major problem in respiratory medicine. Currently, there are no reliable biomarkers for early diagnosis of progressive pulmonary fibrosis, which leads to delayed diagnosis.
Aim. To determine the role of serum biomarkers CA-19-9 and CA-125 and the possibilities of capillaroscopy of the nail fold in the diagnosis of progressive pulmonary fibrosis.
Materials and methods. The study included 43 patients with interstitial changes in the lungs. Based on the presence/absence of signs of progression over the previous 12 months, patients were divided into 2 groups. All patients underwent forced spirometry, body plethysmography, diffusion test, CT, lung ultrasound, capillaroscopy of the nail fold, study of serum concentrations of CA-19-9 and CA-125.
Results. In the group of patients with a progressive fibrotic phenotype of Interstitial lung diseases, a greater severity of capillaroscopic changes and a higher level of CA-19-9 were revealed. Correlation of these parameters with changes according to CT scan data (Warrick test) and lung ultrasound was shown.
Conclusion. The data obtained demonstrate the possibilities of non-invasive diagnosis of progressive fibrosing interstitial lung diseases and require further research and prospective follow-up to assess the diagnostic and prognostic role of the studied biomarkers, as well as to determine their place in clinical practice.