bluuebunny/crossref_metadata_2025 huggingface dataset:
Analogous detection of circulating tumor cells using the AccuCyte®—CyteFinder® system and ISET system in patients with locally advanced and metastatic prostate cancer
Authors: van der Toom Emma E. , Groot Vincent P. , Glavaris Stephanie A. , Gemenetzis Georgios , Chalfin Heather J. , Wood Laura D. , Wolfgang Christopher L. , de la Rosette Jean J.M.C.H. , de Reijke Theo M. , Pienta Kenneth J.
Published: December 2017

Introduction

Circulating tumor cells (CTCs) can provide important information on patient's prognosis and treatment efficacy. Currently, a plethora of methods is available for the detection of these rare cells. We compared the outcomes of two of those methods to enumerate and characterize CTCs in patients with locally advanced and metastatic prostate cancer (PCa). First, the selection‐free AccuCyte® − CyteFinder® system (RareCyte®, Inc., Seattle, WA) and second, the ISET system (Rarecells Diagnostics, France), a CTC detection method based on cell size‐exclusion.

Methods

Peripheral blood samples were obtained from 15 patients with metastatic PCa and processed in parallel, using both methods according to manufacturer's protocol. CTCs were identified by immunofluorescence, using commercially available antibodies to pancytokeratin (PanCK), EpCAM, CD45/CD66b/CD34/CD11b/CD14 (AccuCyte® − CyteFinder® system), and pancytokeratin, vimentin (Vim) and CD45 (ISET system).

Results

The median CTC count was 5 CTCs/7.5 mL (range, 0‐20) for the AccuCyte® − CyteFinder® system and 37 CTCs/7.5 mL (range, 8‐139) for the ISET system (P < 0.001). Total CTC counts obtained for the two methods were correlated (r = 0.750, P = 0.001). When separating the total CTC count obtained with the ISET system in PanCK+/Vim− and PanCK+/Vim+ CTCs, the total CTC count obtained with the AccuCyte® − CyteFinder® system was moderately correlated with the PanCK+/Vim− CTCs, and strongly correlated with the PanCK+/Vim+ CTCs (r = 0.700, P = 0.004 and r = 0.810, P < 0.001, respectively).

Conclusion

Our results highlight significant disparities in the enumeration and phenotype of CTCs detected by both techniques. Although the median amount of CTCs/7.5 mL differed significantly, total CTC counts of both methods were strongly correlated. For future studies, a more uniform approach to the isolation and definition of CTCs based on immunofluorescent stains is needed to provide reproducible results that can be correlated with clinical outcomes.
Thiocarbamate fungicides: reliable tools in resistance management and future outlook
Authors: Thind Tarlochan S , Hollomon Derek W
Published: December 2017

Among contact fungicides, dithiocarbamates have remained successful and are used worldwide. These organic sulfur fungicides, viz. mancozeb, maneb, zineb, ziram, thiram, metiram and propineb, have helped growers manage several economically important plant diseases. Their multi‐site mode of action and broad‐spectrum disease control make them some of the most common partners in mixtures of a number of single‐site fungicides as part of resistance management strategies. Indeed, it was the part played by ethylene‐bis‐dithiocarbamates such as mancozeb in delaying the evolution of phenylamide resistance in several oomycete phytopathogens that laid the groundwork for mixture strategies to become a cornerstone of anti‐resistance management in plant disease control. Dithiocarbamates, however, do not have systemic action, are only surface protectants and have to be applied prior to pathogen infection. Dithiocarbamates will likely continue play a key role as reliable resistance management tools to prolong the efficacy of single‐site fungicides. The primary metabolite ethylene thiourea produced by some of these fungicides is considered a reproductive and endocrine disrupter in animals. Therefore, dithiocarbamates need to be used at reduced rates or in slow‐release formulations. © 2017 Society of Chemical Industry
Counting strongly connected (k1, k2)‐directed cores
Authors: Pittel Boris
Published: December 2017

Consider the set of all digraphs on with M edges, whose minimum in‐degree and minimum out‐degree are at least k1 and k2 respectively. For and , we show that, among those digraphs, the fraction of k‐strongly connected digraphs is . Earlier with Dan Poole we identified a sharp edge‐density threshold for birth of a giant (k1, k2)‐core in the random digraph . Combining the claims, for with probability the giant (k1, k2)‐core exists and is k‐strongly connected.
More effective sprint retrospective with statistical analysis
Authors: Erdoğan Onur , Pekkaya Muhammed Emre , Gök Halime
Published: December 2017

Scrum teams aim to deliver products productively with highest possible value and quality, so they try to deliver high priority and high value product backlog items in earlier sprints. Making size estimation of product backlog items correctly is one of the most prominent factors for effective sprint planning. Retrospective meetings are an opportunity for teams to improve product quality, their productivity, and estimation capability. Enhancing in those areas requires empiricism as agility requires; hence, measureable indicators should be inspected and adapted at regular intervals. In this study, we assessed how and what kind of historical data is required to be collected for monitoring, and how statistical analysis can be investigated for inspection and adaptation in retrospective meetings. We experimented that statistics of “Correlation between Story Point and Actual Effort” and “Consistency of Relative Estimation” were convenient for inspection and adaptation of estimation capability of teams. Past retrospective meetings also showed that statistics of “Team's Actual Effort on Product,” “Team Velocity,” “Actual Effort for One Story Point,” “Innovation Rate,” and “Velocity vs Unplanned Effort Rate” were helpful to control and increase the productivity of teams. “Actual Effort Rate of Quality Activities” and “Subcomponent Defect Density” statistical results helped to enhance product quality.
Detecting opinion spams and fake news using text classification
Authors: Ahmed Hadeer , Traore Issa , Saad Sherif
Published: December 2017

In recent years, deceptive content such as fake news and fake reviews, also known as opinion spams, have increasingly become a dangerous prospect for online users. Fake reviews have affected consumers and stores alike. Furthermore, the problem of fake news has gained attention in 2016, especially in the aftermath of the last U.S. presidential elections. Fake reviews and fake news are a closely related phenomenon as both consist of writing and spreading false information or beliefs. The opinion spam problem was formulated for the first time a few years ago, but it has quickly become a growing research area due to the abundance of user‐generated content. It is now easy for anyone to either write fake reviews or write fake news on the web. The biggest challenge is the lack of an efficient way to tell the difference between a real review and a fake one; even humans are often unable to tell the difference. In this paper, we introduce a new n‐gram model to detect automatically fake contents with a particular focus on fake reviews and fake news. We study and compare 2 different features extraction techniques and 6 machine learning classification techniques. Experimental evaluation using existing public datasets and a newly introduced fake news dataset indicate very encouraging and improved performances compared to the state‐of‐the‐art methods.
Design and Synthesis of Cobalt‐Based Electrocatalysts for Oxygen Reduction Reaction
Authors: Zhong Haihong , Gong Xiaoman , Zhang Shuwei , Tang Pinggui , Li Dianqing , Feng Yongjun
Published: December 2017

Oxygen reduction reaction (ORR) is the crucial step of various renewable energy conversion and storage technologies such as fuel cells and air‐batteries. Cobalt–based electrocatalysts including oxides/chalcogenides and Co−Nx/C, one kind of non‐precious metal electrocatalysts with competitive activity, enhanced durability, and acceptable cost, have been proposed as the potentially interesting alternatives to Pt‐based electrocatalysts. In this account, we summarized the synthesis methods and the corresponding main impact factors including ligand effect, particle size effect, crystal structure, nanostructure, defects and active centers related to the ORR performance on both of oxides/chalcogenides and Co−Nx/C. Some special points have been discussed on design and synthesis of low‐cost and high–performance cobalt‐based electrocatalysts with enhanced electrocatalytic activity. Also, the current challenges and future trends are proposed for improving the performance of Co‐involving electrocatalysts.
Evolutionary leap in large‐scale flood risk assessment needed
Authors: Vorogushyn Sergiy , Bates Paul D. , de Bruijn Karin , Castellarin Attilio , Kreibich Heidi , Priest Sally , Schröter Kai , Bagli Stefano , Blöschl Günter , Domeneghetti Alessio , Gouldby Ben , Klijn Frans , Lammersen Rita , Neal Jeffrey C. , Ridder Nina , Terink Wilco , Viavattene Christophe , Viglione Alberto , Zanardo Stefano , Merz Bruno
Published: December 2017

Current approaches for assessing large‐scale flood risks contravene the fundamental principles of the flood risk system functioning because they largely ignore basic interactions and feedbacks between atmosphere, catchments, river‐floodplain systems, and socioeconomic processes. As a consequence, risk analyses are uncertain and might be biased. However, reliable risk estimates are required for prioritizing national investments in flood risk mitigation or for appraisal and management of insurance portfolios. We review several examples of process interactions and highlight their importance in shaping spatiotemporal risk patterns. We call for a fundamental redesign of the approaches used for large‐scale flood risk assessment. They need to be capable to form a basis for large‐scale flood risk management and insurance policies worldwide facing the challenge of increasing risks due to climate and global change. In particular, implementation of the European Flood Directive needs to be adjusted for the next round of flood risk mapping and development of flood risk management plans focusing on methods accounting for more process interactions in flood risk systems. WIREs Water 2018, 5:e1266. doi: 10.1002/wat2.1266

This article is categorized under:

Science of Water > Water Extremes

Science of Water > Hydrological Processes

Engineering Water > Planning Water
Long‐Lasting Voice‐Related Symptoms in Patients Without Vocal Cord Palsy After Thyroidectomy
Authors: Kim Choung‐Soo , Park Jun Ook , Bae Ja‐Sung , Lee So‐Hee , Joo Young‐Hoon , Park Young‐Hak , Hwang Yeon‐Shin , Shim Mi‐Ran , Sun Dong‐Il
Published: December 2017

Background

Some patients complain of long‐lasting voice symptoms after thyroid surgery without objective vocal fold pathology. We assessed the factors that may influence voice symptoms more than 12 months after thyroidectomy.

Methods

We performed a retrospective analysis of 68 patients from July 2010 to May 2012. The voices of all patients were analyzed before and after thyroid surgery (2 weeks and 2, 4, 6, 8, 10, and 12 months after surgery). According to the recovery of postoperative voice symptoms, patients were divided into two groups: the non‐recovery group and the recovery group. Voice symptoms were measured using a thyroidectomy‐related voice questionnaire (TVQ). We compared voice analysis data for each group and investigated the factors related to long‐lasting postoperative voice symptoms.

Results

Forty‐nine patients were included in the recovery group, and 19 patients were included in the non‐recovery group. No differences in sex ratio, tumor size, and surgical extent were found between the groups. However, the proportion of professional voice users (odds ratio 4.121; 95% confidence interval 0.983–17.267; p < 0.043) was significantly higher in the non‐recovery group. The cutoff score of the TVQ, at 2 months after thyroid surgery, for the differentiation of the recovery and non‐recovery groups was 25, and the sensitivity and specificity values were 84.2 and 87.8%, respectively.

Conclusions

Professional voice users may be presented long‐lasting voice symptoms after thyroid surgery. The cutoff TVQ score of 25, at 2 months after thyroid surgery, may be a guideline for counseling patients who have voice symptoms.
The Value of the C‐Reactive Protein‐to‐Albumin Ratio is Useful for Predicting Survival of Patients with Child–Pugh Class A Undergoing Liver Resection for Hepatocellular Carcinoma
Authors: Shimizu Takayuki , Ishizuka Mitsuru , Suzuki Takashi , Tanaka Genki , Shiraki Takayuki , Sakuraoka Yuhki , Matsumoto Takatsugu , Kato Masato , Aoki Taku , Kubota Keiichi
Published: December 2017

Background

Although a recent study has shown that the C‐reactive protein‐to‐albumin ratio (CAR) can predict the survival in patients with hepatocellular carcinoma (HCC), it is unclear whether CAR can predict the survival after surgery.

Objective

To investigate the utility of CAR for prediction of postoperative survival among HCC patients with Child–Pugh class A.

Methods

We retrospectively reviewed 239 patients with Child–Pugh class A who were newly diagnosed with HCC and received initial liver resection. Univariate and multivariate analyses using the Cox proportional hazard model were performed to detect clinical characteristics that correlated with overall survival (OS), and their cutoff values were identified using receiver operating characteristic curve analyses. The cutoff value of CAR was 0.028. Kaplan–Meier analysis and the log‐rank test were used for the comparison of OS and disease‐free survival (DFS) between two CAR groups (>0.028/≤0.028).

Results

Multivariate analysis using 16 clinical characteristics selected by univariate analyses revealed that CAR (>0.028/≤0.028) (HR, 3.211; 95% CI 1.065–9.680; P = 0.038) was significantly associated with OS, as well as anatomical resection (presence/absence) (HR, 0.275; 95% CI 0.119–0.635; P = 0.275). A significant difference in OS and DFS was observed between patients with low CAR (≤0.028) and patients with high CAR (>0.028).

Conclusions

CAR is a useful predictor of postoperative survival among HCC patients with Child–Pugh class A.
Feasibility of Compliant Flooring in Long-Term Care: Results from a Stakeholder Symposium
Authors: Lachance Chantelle C. , Mackey Dawn C.
Published: December 2017

Le revêtement de sol compliant vise à prévenir les blessures causées par les chutes chez les personnes âgées à risque en soins de longue durée, mais l’utilisation de ce type de revêtement dans ces milieux est encore limitée. Nous avons organisé un symposium d’une journée réunissant les parties prenantes afin d’identifier les avantages et les désavantages de l’installation d’un revêtement de sol compliant en soins de longue durée, ainsi que les questions de recherche future les plus pressantes selon les perspectives des parties prenantes clés. Vingt-trois parties prenantes du domaine de la santé, de l’industrie et de la recherche ont assisté au symposium. Les participants considéraient que les avantages les plus importants de ce revêtement étaient la réduction des blessures pour les résidents qui ont chuté auparavant, les avantages potentiels pour le personnel soignant, et la possibilité d’amélioration de la qualité de vie des résidents. Les désavantages perçus comprenaient des considérations financières, le manque de résultats de recherche concernant ce revêtement et les défis associés à l’installation. Les participants ont indiqué que davantage de recherches étaient nécessaires pour montrer le rapport coût-efficacité et l’efficacité clinique du revêtement de sol compliant. Les parties prenantes ont ainsi perçu que ce revêtement procurait une valeur ajoutée en soins de longue durée, mais ont aussi mis en évidence certaines barrières informationnelles et financières significatives liées à son adoption.
Bridging together: teamwork in caring for the family touched by CHD
Authors: Jonas Richard A.
Published: December 2017

In the opening plenary address of the 2017 7th World Congress of Pediatric Cardiology and Cardiac Surgery the author, who represented the World Society for Pediatric and Congenital Heart Surgery at the Congress and is currently the Society’s president, described the history of the formation of the World Society. He listed accomplishments of the World Society including publication of the only journal devoted to congenital cardiac surgery, development of a global database, and convening several international conferences dating back to the inaugural conference in Washington, DC in 2007. The general theme of the presentation is the importance of teamwork in managing patients and families with CHD. Challenges facing congenital heart teams are discussed including the fragility of cardiac programmes, that can be heavily influenced by the administrative structure of a paediatric hospital; the difficulty of recruiting skilled surgeons into the field as training in general cardiothoracic surgery contracts and general surgery becomes predominantly laparoscopic with few open procedures; and increasing barriers to the international movement of surgeons including the opportunities for United States of America-based surgeons to acquire international experience at leading global centres. Finally, the author focusses on the danger that the team approach poses to maintaining empathy and emotional support for the family with CHD undergoing a stressful hospitalisation. He discusses strategies to optimise holistic support of the child and family.
Landmark lecture on cardiology: the quest for the ultimate team in health care – what we can learn from musicians about leadership, innovation, and teambuilding?
Authors: Penny Daniel J.
Published: December 2017

The importance of teamwork is being increasingly recognised in healthcare. Nonetheless, it is equally recognised that teamwork is difficult. In this article, I explore whether we can learn lessons from musicians, orchestras, and conductors as we build our teams. The evolution of the role of the conductor provides useful lessons on leadership and the evolving role of the members of the orchestra on how team members can contribute to a shared outcome. The uncertainty of jazz provides useful lessons for innovation in an increasingly turbulent healthcare environment.
The 2017 Seventh World Congress of Pediatric Cardiology & Cardiac Surgery: week in review – cardiac surgery
Authors: Karl Tom R.
Published: December 2017

The 2017 Seventh World Congress was held in Barcelona, Spain, 16–21 July. The week in review for this meeting is presented in the current issue of Cardiology in the Young, and herein we discuss the surgical highlights of the programme.
Retrospective and Prospective Memory Among OEF/OIF/OND Veterans With a Self-Reported History of Blast-Related mTBI
Authors: Pagulayan Kathleen F. , Rau Holly , Madathil Renee , Werhane Madeleine , Millard Steven P. , Petrie Eric C. , Parmenter Brett , Peterson Sarah , Sorg Scott , Hendrickson Rebecca , Mayer Cindy , Meabon James S. , Huber Bertrand R. , Raskind Murray , Cook David G. , Peskind Elaine R.
Published: December 2017

Objectives:To evaluate prospective and retrospective memory abilities in Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Operation New Dawn (OND) Veterans with and without a self-reported history of blast-related mild traumatic brain injury (mTBI).Methods:Sixty-one OEF/OIF/OND Veterans, including Veterans with a self-reported history of blast-related mTBI (mTBI group;n=42) and Veterans without a self-reported history of TBI (control group;n=19) completed the Memory for Intentions Test, a measure of prospective memory (PM), and two measures of retrospective memory (RM), the California Verbal Learning Test-II and the Brief Visuospatial Memory Test-Revised.Results:Veterans in the mTBI group exhibited significantly lower PM performance than the control group, but the groups did not differ in their performance on RM measures. Further analysis revealed that Veterans in the mTBI group with current PTSD (mTBI/PTSD+) demonstrated significantly lower performance on the PM measure than Veterans in the control group. PM performance by Veterans in the mTBI group without current PTSD (mTBI/PTSD-) was intermediate between the mTBI/PTSD+ and control groups, and results for the mTBI/PTSD- group were not significantly different from either of the other two groups.Conclusions:Results suggest that PM performance may be a sensitive marker of cognitive dysfunction among OEF/OIF/OND Veterans with a history of self-reported blast-related mTBI and comorbid PTSD. Reduced PM may account, in part, for complaints of cognitive difficulties in this Veteran cohort, even years post-injury. (JINS, 2018,24, 324–334)
HILBERT, DUALITY, AND THE GEOMETRICAL ROOTS OF MODEL THEORY
Authors: EDER GÜNTHER , SCHIEMER GEORG
Published: December 2017

The article investigates one of the key contributions to modern structural mathematics, namely Hilbert’sFoundations of Geometry(1899) and its mathematical roots in nineteenth-century projective geometry. A central innovation of Hilbert’s book was to provide semantically minded independence proofs for various fragments of Euclidean geometry, thereby contributing to the development of the model-theoretic point of view in logical theory. Though it is generally acknowledged that the development of model theory is intimately bound up with innovations in 19th century geometry (in particular, the development of non-Euclidean geometries), so far, little has been said about how exactly model-theoretic concepts grew out of methodological investigations within projective geometry. This article is supposed to fill this lacuna and investigates this geometrical prehistory of modern model theory, eventually leading up to Hilbert’sFoundations.
Bahr, Duce, and Somerville Receive 2017 Ambassador Awards
Authors:   AGU
Published: December 2017

Jean M. Bahr, Robert A. Duce, and Richard C. J. Somerville were awarded the 2017 Ambassador Award at the American Geophysical Union Fall Meeting Honors Ceremony, held on 13 December 2017 in New Orleans, La. The award is in recognition for “outstanding contributions to one or more of the following areas: societal impact, service to the Earth and space community, scientific leadership, and promotion of talent/career pool.”
Impact of Dural Resection on Sinonasal Malignancies with Skull Base Encroachment or Erosion
Authors: Ziai Hedyeh , Yu Eugene , Fu Terence , Muhanna Nidal , Monteiro Eric , Vescan Allan , Zadeh Gelareh , Witterick Ian , Goldstein David , Gentili Fred , de Almeida John
Published: December 2017

Objectives (1) To determine the occult rate of dural invasion in patients with tumors extending to and/or eroding the bony anterior skull base but without evidence of dural invasion on preoperative imaging. (2) To determine the impact of dural resection and of skull base erosion on survival outcomes in this group of patients (without evidence of dural invasion upon preoperative imaging).

Study Design Retrospective study.

Setting Tertiary care academic center.

Participants Patients with sinonasal malignancies with anterior skull base encroachment/erosion without dural invasion on preoperative imaging treated surgically.

Main Outcome Measures (1) Histopathologic disease in the dura in patients who had dural resection and (2) Oncologic outcomes (5-year local recurrence, dural recurrence, disease-specific survival, and overall survival) in patients with and without dural resection, and patients with and without skull base erosion.

Results Thirty-seven patients were included. The occult rate of dural invasion was 54%. Patients with dural resection had improved margin control versus those without dural resection (90% vs 56%, p = 0.02). Dural resection improved 5-year overall survival only in patients with esthesioneuroblastoma compared with bony skull base resection alone (100% vs 75%, p = 0.03). Patients with skull base erosion had reduced local control versus those without erosion (63% vs 93%, p = 0.047).

Conclusion This study suggests a substantial rate of occult dural invasion despite no overt imaging findings. Dural resection may be associated with improved margin control, but no oncologic benefit except for esthesioneuroblastomas, although treatment heterogeneity and small sample size may limit conclusions.
Case Report of Proliferative Peripheral Retinopathy in Two Familial Lissencephaly Infants with Miller–Dieker Syndrome
Authors: Shoukfeh Omar , Prouty Leonard , Hinrichsen John , Spencer William , Langford Marlyn , Richards Alan
Published: December 2017

A complete ophthalmic examination is not routinely performed on infants with Miller–Dieker syndrome (MDS, chromosome 17p13.3 microdeletion). The authors present the cases of four cousins with MDS who also carried a 16p13.3 microduplication (not associated with Rubinstein–Taybi syndrome). Retinopathy of prematurity-like proliferative peripheral retinopathy (PPR) was detected in two male first cousins, but was not detected in the female half-cousins. PPR in the first infant resolved by 4 months, but the second infant's PPR progressed, requiring photocoagulation followed by lens-sparing vitrectomy. While ocular abnormalities are more prevalent and severe in other lissencephalopathies, the PPR in these MDS infants underscores the sight-saving potential of performing an ophthalmologic exam with early molecular testing for all lissencephaly infants.
A Case Report of Fatal Necrotizing Encephalitis and Acute HBV Infection: Coincidence or Comorbidity?
Authors: Krzysztofiak Andrzej , Russo Cristina , De Vito Rita , Nobili Valerio , Villani Alberto , Bozzola Elena
Published: December 2017

We report the first fatal pediatric case of encephalitis associated with hepatitis B virus (HBV) infection. A Caucasian, previously healthy, and vaccinated 7-year-old girl was evaluated at our hospital for fever, vomiting, tremors, and loss of consciousness. At admission, she underwent brain computed tomographic scan, electroencephalogram, lumbar puncture, and blood examination. In 12 hours, her clinical condition deteriorated and the patient entered coma and died. A laboratory error was useful to reach a predeath diagnosis, showing HBV–DNA on blood. Autopsy confirmed HBV–PCR DNA in brain, lymphnodes, lungs, liver, and spleen. We generally do not search HBV–DNA in organic fluid of Italian children with encephalitis, as they are currently all vaccinated. Consequently, as a teaching lesson, we would suggest not to take anything obvious.
Growth Impairment in Acute Central Infectious Diseases
Authors: Meazza Cristina , Bossi Grazia , Comoli Patrizia , Bozzola Elena , Bozzola Mauro
Published: December 2017

Acute meningitis is an inflammation of the meninges affecting the pia, arachnoid, and subarachnoid space that still causes morbidity and mortality. Among the sequelae of meningitis, endocrine complications have been reported in patients recovering from acute central infectious diseases. Although the results of the studies are conflicting, the most common pituitary hormone deficiency during the acute phase or at 1-year follow-up evaluation is growth hormone deficiency, which results in growth impairment in children and a dysregulation of body composition and lipid metabolism throughout life. The mechanisms involved in growth failure secondary to meningitis are unknown. Therefore, endocrinological evaluation, including clinical, auxological, and hormonal assessments, should be performed during the acute phase of the infection and during recovery.
A Case of Fatal Pulmonary Hypoplasia with Congenital Diaphragmatic Hernia, Thoracic Myelomeningocele, and Thoracic Dysplasia
Authors: Ito Ai , Fujinaga Hideshi , Matsui Sachiko , Tago Kumiko , Iwasaki Yuka , Fujino Shuhei , Nagasawa Junko , Amari Shoichiro , Kaneshige Masao , Wada Yuka , Takahashi Shigehiro , Tsukamoto Keiko , Miyazaki Osamu , Yoshioka Takako , Ishiguro Akira , Ito Yushi
Published: December 2017

Background Congenital diaphragmatic hernia (CDH) is fatal in severe cases of pulmonary hypoplasia. We experienced a fatal case of pulmonary hypoplasia due to CDH, thoracic myelomeningocele (MMC), and thoracic dysplasia. This constellation of anomalies has not been previously reported.

Case Report A male infant with a prenatal diagnosis of thoracic MMC with severe hydrocephalus and scoliosis was born at 36 weeks of gestation. CDH was found after birth and the patient died of respiratory failure due to pulmonary hypoplasia and persistent pulmonary hypertension of the newborn at 30 hours of age despite neonatal intensive care. An autopsy revealed a left CDH without herniation of the liver or stomach into the thoracic cavity, severe hydrocephalus, Chiari malformation type II, MMC with spina bifida from Th4 to Th12, hemivertebrae, fused ribs, deformities of the thoracic cage and legs, short trunk, and agenesis of the left kidney.

Conclusion We speculate that two factors may be associated with the severe pulmonary hypoplasia: decreased thoracic space due to the herniation of visceral organs caused by CDH and thoracic dysplasia due to skeletal deformity and severe scoliosis.
Outcomes of Medically Indicated Preterm Births Differ by Indication
Authors: Kuper Spencer , Steele Robin , Sievert Rachel , Tita Alan , Harper Lorie , Wang Michelle
Published: December 2017

Objective We aim to examine whether outcomes of preterm birth (PTB) are further modified by the indication for delivery.

Study Design We performed a retrospective cohort study of all singletons delivered at 23 to 34 weeks from 2011 to 2014. Women were classified by their primary indication for delivery: maternal (preeclampsia) or fetal/obstetric (growth restriction, nonreassuring fetal status, and vaginal bleeding). The primary neonatal outcome was a composite of neonatal death, cord pH <7 or base excess < − 12, 5-minute Apgar ≤3, C-reactive protein during resuscitation, culture-proven sepsis, intraventricular hemorrhage, and necrotizing enterocolitis. Secondary outcomes included the individual components of the primary outcome. Groups were compared using Student's t-test and chi-squared tests. Logistic regression was used to adjust for confounding variables.

Results Of 528 women, 395 (74.8%) were delivered for maternal and 133 (25.2%) for fetal/obstetric indications. Compared with those delivered for a maternal indication, those with a fetal/obstetric indication for delivery had an increased risk of the composite neonatal outcome (adjusted odds ratio [AOR]: 1.9, 95% confidence interval [CI]: 1.13–3.21) and acidemia at birth (AOR: 4.2, 95% CI: 1.89–9.55).

Conclusion Preterm infants delivered for fetal/obstetric indications have worsened outcomes compared with those delivered for maternal indications. Additional research is needed to further tailor counseling specific to the indication for delivery.
Die aktuellen Leitlinien für Autologe Fettgewebstransplantationen der Deutschen Gesellschaft der Plastischen,
Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC) und der Fat Graft Task Force der American Society of Plastic Surgeons (ASPS) – ein
transatlantischer Vergleich
Authors: Broelsch G. Felix , Könneker Sören , Ipaktchi Ramin , Vogt Peter M.
Published: December 2017

Problemstellung Die zunehmende Verwendung von autologen Fetttransplantationen veranlasste 2009 die American Society of Plastic
Surgeons eine Fat Graft Task Force (AFGT) zu etablieren und in 2015 die Deutsche Gesellschaft der Plastischen, Rekonstruktiven und
Ästhetischen Chirurgen (DGPRÄC) gemeinsam mit drei weiteren Fachgesellschaften (DDG, DGMKG, DGGG) an Hand der bislang publizierten
Ergebnissen Behandlungsleitlinien zu erstellen. Die vorliegende Arbeit will die beiden Leitlinien hinsichtlich Ihres Anliegens, einer
sicheren Durchführung von autologer Fetttransplantation, vergleichen.

Methoden Die AFGT stützt ihre Empfehlungen ausschließlich auf Parameter der evidenzbasierten Medizin. Die DGPRÄC bewertet unter
Berücksichtigung der aktuellen Literatur im Rahmen eines vierstufigen Expertenkonsenses das Vorgehen nach allgemeinen Anforderungen der
Operativen Medizin und gesetzlichen Vorgaben.

Ergebnisse Beide Gesellschaften stimmen in Indikation und technischen Vorgehen weitestgehend überein: Fetttransplantationen sind
indiziert zum Brustaufbau, zur Rekonstruktion von Gewebsdefiziten oder Deformitäten. Beide weisen auf die Risikogruppe bestimmter
Brusttumoren (BRCA-1, BRCA-2) bzw. familiäre Prädispositionen hin. In fast allen Anwendungsbereichen sind Ergebnisse abhängig von der
verwendeten Applikationstechnik und den Erfahrungen eines Operateurs. Randomisierte, prospektive Studien für bestimmte Verfahren fehlen.
Aufgrund der Einzelberichte und Expertenmeinungen liegt zwar nur eine Evidenz-Stufe von IV–V nach Einschätzung der AFGT vor. Demgegenüber
vermittelt die DGPRÄC detailliertere Vorgehensverfahren und erreicht durch das Experten-Konsensusverfahren eine deutlich stärkere
Aussagefähigkeit als die Leitlinie der AFGT.

Zusammenfassung Beide Expertengremien empfehlen die Durchführung autologer Fetttransplantationen bei entsprechenden Indikationen und
weisen darauf hin, dass es keine Standardverfahren für ein bestimmtes Vorgehen gibt. Die publizierten Leitlinien sollen Hinweise geben auf
die richtige Patientenselektion, eine optimale Technik, mögliche Komplikationen und realistische Erfolgsaussichten. Die DGPRÄC empfiehlt die
Einhaltung der von ihr gegebenen praktischen Einzelrichtlinien einschließlich der gesetzlichen Vorgaben, um die Patientensicherheit zu
gewährleisten und ist damit in der Praxis richtungsweisender und verbindlicher. Die AFGT rät dringend zur erweiterten Grundlagenforschung
und zur Durchführung randomisierter, prospektiver Studien.
Wunschoperationen bei Jugendlichen am Beispiel der Mamma-Reduktionsplastik
Authors: Bruck Johannes C. , Wipper Anna-Kristine
Published: December 2017

Die Kenntnis über medizinischen Möglichkeiten zur Optimierung des eigenen Körperbildes geht auch an Jugendlichen nicht spurlos vorüber. Auch
wenn der überwältigende Anteil an Operationen bei Jugendlichen sich auf das Anlegen von Ohren konzentriert, werden doch rund 4 % aller
Operationen an Jugendlichen an der Brust vorgenommen. Auch wenn die Menarche in den letzten Jahren kaum mehr verschoben wurde, scheint
Adipositas auch für die Entwicklung der Brüste junger Mädchen eine Rolle zu spielen. Angesichts der schwierigen Erfassung des Reifegrades
und der psychischen Belastbarkeit jugendlicher Patienten gerät der Plastische Chirurg leicht in ein besonderes Spannungsfeld zwischen dem
Wunsch ein nachvollziehbares Leid lindern zu wollen, einen nachhaltig befriedigenden Behandlungserfolg zu erzielen und in weiten Teilen
unsicheren rechtlichen Rahmenbedingungen zu genügen. In der Darstellung der Rechtsprechung und einschlägiger Gesetzgebung wird die besondere
rechtliche Situation Jugendlicher dargestellt und Empfehlungen zur Überbrückung juristischer Unsicherheiten gegeben. Ziel der
Indikationsstellung wird in diesen Fällen sein müssen, die Entscheidungsfindung auf möglichst breite Beine zu stellen und mögliche
Einflussnahmen durch Dritte in besonderer Weise zu berücksichtigen um ein dauerhaft befriedigendes Ergebnis für alle Beteiligten zu
erzielen.
Versorgungsforschung – Gegenstand einer neuen Wissenschaft oder transdisziplinäre Aktivität?
Authors: Mansmann Ulrich
Published: December 2017

Das Positionspapier des DNVF impliziert meine Titelfrage in seinem letzten Satz: Dies birgt für die Versorgungsforschung die … Option, sich … als reifes und verantwortungsvolles Wissenschaftsgebiet zu präsentieren. Die Autoren kommen zu dieser Schlussfolgerung nach einer Diskussion zur raschen Weiterentwicklung digitaler Technologien im Gesundheitswesen und deren Evaluation hinsichtlich gesellschaftlichen Nutzens und gesellschaftlicher Risiken. Ihr Papier behandelt keine Fragen, die einem wissenschaftsinternen Diskurs entspringen. Es diskutiert ein integratives Forschungsprinzip, das wissenschaftliches und praktisches Wissen verbindet. Dieses Forschungsprinzip ist integrationsorientiert und transdisziplinär. Es vermittelt keine Methoden zwischen sondern bedient sich der Methoden unterschiedlicher Disziplinen.
HaMiPla Best Paper Sitzungen – Ihre Favoriten 2016
Authors: Maier Katrin , Giunta Riccardo E. , Prommersberger Karl-Josef
Published: December 2017

Alljährlich zeichnen die Herausgeber und die Thieme-Gruppe mit dem HaMiPla Best-Paper-Award die Top Publikationen in Handchirurgie und
Plastischer Chirurgie aus, die unsere Leser und Nutzer im vergangenen Jahr am meisten interessiert haben. Gemessen wird dies anhand der
online-Zugriffstatistiken auf die im jeweiligen Jahr veröffentlichten Artikel.
Implementation of one-dimensional domain wall dynamics simulator
Authors: Kim Hyungsuk , Heo Seo Weon , You Chun-Yeol
Published: December 2017

We implemented a one-dimensional domain wall (DW) dynamics simulator based on the well-developed collective coordinate approach to demonstrate DW motion under a given magnetic field and/or current flow. The simulator adopted all known influences, including three-dimensional external magnetic fields, spin transfer torque with non-adiabatic contribution, spin Hall effect, Rashba effect, and Dzyaloshinskii-Moriya interaction. The simulator can calculate the position, velocity, internal magnetization angle, and tilting angle of the domain wall to the current direction or wire axis under given simulation conditions and material parameters. It will not only provide physical insights of domain wall dynamics to experimentalists, but also can be used to more easily simulate various physical circumstances before running time-consuming micromagnetic simulations or real experiments.
Volume-amplified magnetic bioassay integrated with microfluidic sample handling and high-Tc SQUID magnetic readout
Authors: Sepehri Sobhan , Eriksson Emil , Kalaboukhov Alexei , Zardán Gómez de la Torre Teresa , Kustanovich Kiryl , Jesorka Aldo , Schneiderman Justin F. , Blomgren Jakob , Johansson Christer , Strømme Maria , Winkler Dag
Published: December 2017

A bioassay based on a high-Tc superconducting quantum interference device (SQUID) reading out functionalized magnetic nanoparticles (fMNPs) in a prototype microfluidic platform is presented. The target molecule recognition is based on volume amplification using padlock-probe-ligation followed by rolling circle amplification (RCA). The MNPs are functionalized with single-stranded oligonucleotides, which give a specific binding of the MNPs to the large RCA coil product, resulting in a large change in the amplitude of the imaginary part of the ac magnetic susceptibility. The RCA products from amplification of synthetic Vibrio cholera target DNA were investigated using our SQUID ac susceptibility system in microfluidic channel with an equivalent sample volume of 3 μl. From extrapolation of the linear dependence of the SQUID signal versus concentration of the RCA coils, it is found that the projected limit of detection for our system is about 1.0 × 105 RCA coils (0.2 × 10−18 mol), which is equivalent to 66 fM in the 3 μl sample volume. This ultra-high magnetic sensitivity and integration with microfluidic sample handling are critical steps towards magnetic bioassays for rapid detection of DNA and RNA targets at the point of care.
Magnetoresistance originated from charge-spin conversion in ferromagnet
Authors: Taniguchi Tomohiro
Published: December 2017

Transverse magnetoresistance in a ferromagnetic/nonmagnetic/ferromagnetic trilayer originated from charge-spin conversion by anomalous Hall effect is investigated theoretically. Solving the spin diffusion equation in bulk and using the spin-dependent Landauer formula at the ferromagnetic/nonmagnetic interface, an analytical formula of the transverse resistivity is obtained. The charge-spin conversion by the anomalous Hall effect contributes to the magnetoresistance in a manner proportional to the square of the spin anomalous Hall angle. The angular dependence of the magnetoresistance is basically identical to that of planar Hall effect, but has an additional term which depends on the relative angle of the magnetizations in two ferromagnets.
Characterization of high κ Al2O3 based metal-insulator-metal antifuse
Authors: Tian Min , Zhong Huicai , Li Li , Wang Zhigang
Published: December 2017

A new metal-insulator-metal (MIM) antifuse structure was fabricated with the amorphous Al2O3 synthesized by atomic layer deposition (ALD) as the dielectric and with either Ti or TiN as top electrode. The device with Ti electrode exhibits lower breakdown voltage compared to the TiN counterpart due to the more oxygen vacancies in Ti electrode antifuse. During breakdown, the effective programming current is found to be several orders larger than the compliance current, and resulting in extremely low on-state resistance. A hypothesis based on the electron trap of oxygen vacancy in the bulk of Al2O3 is proposed to explain this breakdown characteristics.
Envelope detection using temporal magnetization dynamics of resonantly interacting spin-torque oscillator
Authors: Nakamura Y. , Nishikawa M. , Osawa H. , Okamoto Y. , Kanao T. , Sato R.
Published: December 2017

In this article, we propose the detection method of the recorded data pattern by the envelope of the temporal magnetization dynamics of resonantly interacting spin-torque oscillator on the microwave assisted magnetic recording for three-dimensional magnetic recording. We simulate the envelope of the waveform from recorded dots with the staggered magnetization configuration, which are calculated by using a micromagnetic simulation. We study the data detection methods for the envelope and propose a soft-output Viterbi algorithm (SOVA) for partial response (PR) system as a signal processing system for three dimensional magnetic recording.
Hydrostatic pressure-tuned magnetostructural transition and magnetocaloric effect in Mn-Co-Ge-In compounds
Authors: Liang F. X. , Shen F. R. , Liu Y. , Li J. , Qiao K. M. , Wang J. , Hu F. X. , Sun J. R. , Shen B. G.
Published: December 2017

Polycrystalline MnCoGe0.99In0.01 with magnetostructural transition temperature (Tmstr) around 330 K has been prepared by arc-melting technique, and the pressure-tuned magnetostructural transition as well as the magnetocaloric effect (MCE) has been investigated. The experimental results indicate that a pressure (P) smaller than 0.53 GPa can shift Tmstr to lower temperature at a considerable rate of 119 K/GPa with the coupled nature of magnetostructural transition unchanged. However, as P reaches 0.53 GPa, the martensitic structural transition temperature (TM) further shifts to 254 K while the magnetic transition temperature of austenitic phase (TCA) occurs at around 282 K, denoting the decoupling of magnetostructural transition. Further increasing P to 0.87 GPa leads the further shift of TM to a lower temperature while the TCA keeps nearly unchanged. Therefore, the entropy change (ΔS) of the MnCoGe0.99In0.01 under different magnetic fields can be tailored by adjusting the hydrostatic pressure.
Preparation and evaluation of Mn3GaN1-x thin films with controlled N compositions
Authors: Ishino Sunao , So Jongmin , Goto Hirotaka , Hajiri Tetsuya , Asano Hidefumi
Published: December 2017

Thin films of antiperovskite Mn3GaN1-x were grown on MgO (001) substrates by reactive magnetron sputtering, and their structural, magnetic, and magneto-optical properties were systematically investigated. It was found that the combination of the deposition rate and the N2 gas partial pressure could produce epitaxial films with a wide range of N composition (N-deficiency) and resulting c/a values (0.93 - 1.0). While the films with c/a = 0.992 - 1.0 were antiferromagnetic, the films with c/a = 0.93 - 0.989 showed perpendicular magnetic anisotropy (PMA) with the maximum PMA energy up to 1.5×106 erg/cm3. Systematic dependences of the energy spectra of the polar Kerr signals on the c/a ratio were observed, and the Kerr ellipticity was as large as 2.4 deg. at 1.9 eV for perpendicularly magnetized ferromagnetic thin films with c/a = 0.975. These results highlight that the tetragonal distortion plays an important role in magnetic and magneto-optical properties of Mn3GaN1-x thin films.
Continuous and jumpwise reversal magnetization in [Mn(II)(HL)(H2O)][Mn(III)(CN)6]·2H2O molecular ferrimagnet
Authors: Kirman M. V. , Vasiliev L. A. , Morgunov R. B.
Published: December 2017

Magnetic jumps with the amplitudes of 0.01%–0.1% of the saturation magnetization were observed during the magnetization reversal of a [Mn(II)(HL)(H2O)][Mn(III)(CN)6]·2H2O molecular ferrimagnet. Fourier transform of the time series of the magnetization jumps showed that its frequency spectrum is close to that of white noise. The distribution of the jump amplitudes versus time revealed that large jumps dominate at the onset of magnetization reversal.
Magnetic and magnetocaloric properties of the La0.9−xAgxMn1.1O3 compounds
Authors: Zubov E. , Pashchenko A. , Nedelko N. , Radelytskiy I. , Dyakonov K. , Krzyżewski A. , Ślawska-Waniewska A. , Dyakonov V. , Szymczak H.
Published: December 2017

The influence of Ag+ ions and Mn non-stoichiometry on the magnetic properties and magnetocaloric effect in the La0.9–xAgxMn1.1O3 compounds has been studied. The Ag+ ions content substituting for trivalent lanthanum ions was varied from x = 0.05 to 0.3. Magnetic measurements have been performed over a wide temperature (350–5 K) and magnetic field (up to 5 T) ranges. All the manganites studied show the ferromagnetic-like ordering with a first order magnetic phase transition. The magnetic entropy changes were evaluated from the isothermal curves of magnetization versus an applied magnetic field using both the thermodynamic Maxwell relation (MR) and calculation based on the Landau theory of phase transitions. The largest values of the magnetocaloric effect as well as the relative cooling power among the studied manganites are equal to 5.76 J/(kg K) and 185 J/kg, respectively, for La0.7Ag0.2Mn1.1O3 in the magnetic field change of 5 T near the Curie temperature of TC = 271 K. A good correlation between the magnetization, colossal magnetoresistance and magnetic entropy changes as a function of Ag concentration in the La0.9–xAgxMn1.1O3 manganites was established.
Effect of deformation on the structure of polyimide PM-A at low temperatures
Authors: Braude I. S. , Galtsov N. N. , Geidarov V. G. , Kirichenko G. I. , Lototskaya V. A. , Plotnikova Yu. M.
Published: December 2017

Films of polyimide PM-A were studied by x-ray diffractometry after deformation at liquid nitrogen and liquid helium temperatures. Deformation at liquid nitrogen temperature causes the formation of two regions with different densities in the films. Deformation of the films at liquid helium temperature does not cause significant changes in their structure. Assuming that the films consist of quasilinear chain molecules, two mechanisms are proposed which provide a qualitative description of the processes taking place in polyimide PM-A films after deformation at low temperatures.
Isolated spherical impurity in noble gas crystals
Authors: Strzhemechny M. A. , Danchuk V. V. , Legchenkova I. V.
Published: December 2017

To explain the experimentally observed structural anomalies in diluted solid solutions of argon in krypton, we calculated the positions of atoms in a nine-layer spherical cluster of krypton with an argon atom in the center. The interaction was approximated with the Lenard–Jones potential. The substitution volume ω of an argon atom in the krypton crystal was calculated. It was shown that compared to the generally accepted estimates obtained within the nearest-neighbor approximation, the value of ω is approximately twice as small. This effect is explained by an additional repulsion of the first coordination sphere of krypton atoms arising as the krypton atoms approach each other upon their inward motion.
Magnetic bioassay system progresses toward versatile device for rapid point-of-care diagnosis
Authors: Bello Mark
Published: December 2017

Integration of lab-on-chip technology, high-T c  superconductor sensor, magnetic nanoparticles, and nucleic acid amplification into a tabletop system detects pathogens with high-sensitivity.
High frequencies in random forcing affect turbulence simulations
Authors: Kim Meeri
Published: December 2017

An investigation into white noise forcing reveals it may not be the best choice for idealized simulations of atmospheric and oceanic turbulence.