bluuebunny/crossref_metadata_2025 huggingface dataset:
UTILIZAÇÃO DO GOOGLE EARTH ENGINE PARA ANÁLISE COMPARATIVA DA LINHA DE COSTA DE DOIS DELTAS DA COSTA LESTE BRASILEIRA ENTRE 1986 E 2021: Delta do rio São Francisco (Al/Se) e delta do rio Paraíba Do Sul (Rj)
Authors: Almeida Karina Costa de , Costa André Paulo Ferreira da , Rocha Thais Baptista da
Published: July 2023

O Google Earth Engine (GEE) tem proporcionado subsídio às pesquisas multitemporais devido a seu rápido e gratuito processamento em nuvem. Os deltas do rio São Francisco e do rio Paraíba do Sul estão localizados na costa leste brasileira e são classificados como deltas dominados por ondas, segundo Galloway (1975). A construção de suas planícies deltaicas ocorre a partir da incorporação de Barreiras Arenosas Costeiras (BACs) e nos dois casos ocorre a formação de spits (BACs conectada à planície por apenas uma das extremidades). Para análise da trajetória espectral dos pixels entre os anos de 1986 e 2021, foram utilizadas as coleções de imagem Landsat 5 e Landsat 8. Para a detecção de mudança, foi aplicado o índice MNDWI (Modified Normalized Difference Water Index). Os resultados mostraram as áreas de acreção e recuo da linha de costa. O delta do rio São Francisco teve balanço de área negativo de - 0,1206 km², enquanto do delta do rio Paraíba do Sul obteve balanço positivo de 0,2318. Foram identificadas áreas de erosão costeira, que podem estar relacionadas à ação antrópica sobretudo no caso do delta do São Francisco, devido às construções de barragens nas bacias de drenagem que alteram a carga sedimentar fluvial.
Vozes dissonantes no documentário Dundo, memória colonial: embates de narrativas
Authors: Recchia Márcio Aurélio
Published: July 2023

Este artigo visa analisar algumas das memórias acerca do período colonial português no documentário Dundo, memória colonial (2009), da documentarista portuguesa Diana Andringa. Nascida em 1947 no Dundo, Angola, então colônia portuguesa, ela se muda para Portugal com sua família aos onze anos de idade. O documentário aborda o seu retorno à sua terra natal cinquenta anos mais tarde, na companhia de sua filha. As lembranças de infância de Andringa divergem da realidade local, além de serem contrastadas por relatos de angolanos que viveram sob o jugo do regime colonial. A análise parte do pressuposto teórico de que todo filme é um objeto de estudo independente, portanto, que vai além das escolhas e intenções de seu realizador (FERRO, 1995), como pretendemos demonstrar neste artigo.
Fazendeiros e membros de boas famílias: análise das propriedades e da nobreza de homens da agricultura de abastecimento (Nova Friburgo – 1850-1883)
Authors: Frazão Gabriel Almeida
Published: July 2023

O artigo objetiva demonstrar a importância da produção de gêneros para o mercado interno, entre 1850 e 1883, em parte do território de Nova Friburgo: as Terras Frias. Ele dialoga com a História Agrária e ratifica a defesa de análises regionais para o entendimento da agricultura brasileira. Por meio da microanálise e da variação de escalas, ele se fundamenta na reflexão bibliográfica e na apreciação de fontes como: periódicos; documentos eclesiásticos, administrativos; e inventários de fazendeiros locais. Por meio delas, foi possível compreender que os sujeitos envolvidos na produção para o abastecimento não estavam alijados do mercado, possuíam vários bens e se inseriam na escravidão. O sucesso econômico permitiu que participassem da administração pública. Esses membros da boa sociedade construíram prestígio social, o que os permitiu se distinguir socialmente.
QUESTÕES SOCIOCIENTÍFICAS BALIZADAS POR DIMENSÕES CONCEITUAIS, PROCEDIMENTAIS E ATITUDINAIS NA FORMAÇÃO INICIAL DE PROFESSORES
Authors: Funari Catiucia Anselmo , Lindemann Renata Hernandez
Published: July 2023

Por meio deste artigo, discutiram-se as contribuições da abordagem de Questões Sociocientíficas (QSC) na formação inicial de professores de Química, refletindo a respeito do desenvolvimento, das dimensões Conceituais, Procedimentais e Atitudinais (CPA) apresentadas por Conrado e Nunes Neto (2018). A pesquisa foi realizada junto ao curso de Química-Licenciatura da Universidade Federal do Pampa (UNIPAMPA), no componente de Produção de Material Didático para o Ensino de Química, no período da pandemia da covid-19. A intervenção aconteceu em quatro encontros. A coleta de dados foi realizada por meio de transcrição das aulas e do webfólio e da análise das Unidades Temáticas produzidas pelos estudantes, contemplando o uso das QSC. A Análise Textual Discursiva (MORAES; GALIAZZI, 2016) foi a metodologia analítica empregada para a discussão de três categorias, a saber: desvelando a dimensão conceitual na formação inicial de professores; os achados da dimensão procedimental; e comprometimento dos licenciados com a dimensão atitudinal. Os resultados apontaram que as QSC possuem potencial para serem incorporadas como estratégia nos currículos de formação de professores de Ciências da Natureza, pois possibilitam promover uma visão ampliada da Ciência e Tecnologia.
O uso da realidade aumentada no ensino de ciências e biologia : o que dizem os licenciandos em Ciências Biológicas?
Authors: Ribeiro Freire Juliana , Cabral de Oliveira Carlos Bruno , Guelero do Valle Mariana
Published: July 2023

O presente trabalho objetivou investigar o uso da Realidade Aumentada (RA) no ensino de ciências e biologia na perspectiva de licenciandos em ciências biológicas. O público-alvo foram licenciandos em Ciências Biológicas de uma instituição de ensino superior no Maranhão e a coleta de dados ocorreu em uma oficina de Tecnologias Digitais de Informação e Comunicação (TDIC), em que os participantes puderam experienciar a RA por meio do aplicativo Google Expedições. Foi-lhes apresentado um questionário que versava sobre o uso da RA no ensino. Para análise dos dados, foram traçadas três categorias: operabilidade, envolvimento e efetividade. A RA traz uma perspectiva atraente para os alunos, para isso, é importante haver um planejamento que leve em consideração a disponibilidade de recursos e a infraestrutura escolar. É necessário que a formação inicial promova uma visão global das potencialidades dessas ferramentas, além de maiores investimentos para a garantia do acesso aos recursos tecnológicos.
Eu brinco, tu brincas, nós brincamos: o corpo e o movimento na formação de professores para a Educação Infantil
Authors: Camargo Daiana , Dornelles Leni Vieira
Published: July 2023

Tomamos como ponto de partida as inquietações acerca do brincar no cotidiano da Educação Infantil, considerando que a formação do professor é um importante elemento para a valorização e o redimensionamento do brincar. Nesta perspectiva, nos propusemos a investigar e discutir o brincar na formação de professores para a EI, permeado por uma compreensão das crianças, de suas infâncias e das instituições de ensino a elas destinadas. Trazemos uma discussão teórica sobre a temática, apresentando abordagens de estudiosos do brincar, do corpo em movimento e da formação de professores, articuladas a algumas falas de acadêmicos de pedagogia sobre brincar, o corpo e o movimento na sua formação, no curso superior. Neste emaranhado de falas, referências e análises, tratamos do brincar, do corpo e da acrobacia cotidiana que é educar e aprender com as crianças, considerando que a formação de professores de EI precisa estar vinculada ao movimento, à vivência estética e à compreensão da arte e das culturas infantis.
Aprendizagem ao longo da vida e suas nuances: fundamentos e decreto nº 10.502/2020
Authors: Carvalho da Costa Lima Landim Caroline , Santos Rebelo Andressa
Published: July 2023

Neste artigo objetiva-se apresentar uma análise do conceito de Aprendizagem ao Longo da Vida (ALV), tendo em vista sua previsão expressa na Política Nacional de Educação Especial: Equitativa, Inclusiva e com Aprendizado ao Longo da Vida (PNEE-2020) e Decreto nº 10.502 de 30 de setembro de 2020, revogado recentemente pelo Decreto nº 11.370 de 1º de janeiro de 2023, no governo Lula. A pesquisa foi desenvolvida por meio da abordagem qualitativa e análise documental, a partir de documentos normativos e orientadores da Educação Especial. Busca-se identificar os fundamentos da Aprendizagem ao Longo da Vida (ALV), instituída no Decreto, principalmente quando tal conceito também surge, no âmbito da Educação Especial brasileira. Foi possível compreender os aspectos históricos e sua significação a partir de seu surgimento na legislação brasileira, que vem demonstrando tensões, diante da repercussão do tema. Destaca-se debates relacionados a conceitos polissêmicos, com a continuidade dos habituais modos de entender o público-alvo da Educação Especial, com definições vagas, sem especificar como e de que forma será concretizada.
Avaliação dinâmica: encontros e desencontros na educação inclusiva
Authors: Santana Ana Paula Oliveira , Figueira Ana Paula Mendes Correia Couceiro
Published: July 2023

O modelo de avaliação da aprendizagem escolar para alunos da educação especial tem sido pouco discutido. Não há documentos orientadores definidos para esse tema. Diante disso, muitas vezes as avaliações são realizadas de forma estática e classificatória sem, contudo, apontar as potencialidades dos sujeitos. Muito embora a perspectiva sócio-histórica tenha permeado vários documentos governamentais, a avaliação realizada a partir dessa perspectiva não tem sido privilegiada. Nesse sentido, o objetivo desse estudo é discutir a avaliação dinâmica como possibilidade de trabalho para a educação especial na perspectiva da educação inclusiva. Faremos isso a partir de uma revisão crítica de literatura.  Este estudo revelou lacunas nas referências bibliográficas sobre esse tema. A avaliação dinâmica deve e pode ser considerada como potencialmente importante para o contexto da educação especial pois ela leva em conta a singularidade e o processo de aprendizagem de cada sujeito, a partir da mediação do professor. Desta forma, acredita-se que a discussão sobre a avaliação dinâmica de perspectiva vygotskyana, vai ao encontro de uma educação inclusiva e para todos.
Não comunicar não é uma alternativa: o uso do dispositivo gerador de fala para alunos com autismo
Authors: Nascimento Fabiana Ferreira do , Cruz Mara Lucia Reis Monteiro da , Silva Thatyana Machado
Published: July 2023

O dispositivo gerador de fala (DGF) tem sido apresentado como uma ferramenta promissora para favorecer a comunicação de pessoas que apresentem necessidades complexas de comunicação. O foco dessa pesquisa foi apresentar uma introdução sobre o uso desse dispositivo e seus efeitos para uma criança com diagnóstico de Transtorno do espectro do autismo, no ambiente escolar. O objetivo foi discutir as suas potencialidades e evidenciar através do uso da Matriz de comunicação a evolução do perfil comunicativo do aluno após os procedimentos de intervenção. O artigo apresenta um recorte de uma investigação de doutorado que utilizou como método um delineamento quase experimental do tipo A-B. Os resultados apontaram para o uso exponencial, pelo aluno, da comunicação alternativa como forma de expressar desejos e sentimentos. As escolas e seus atores precisam apostar mais nos benefícios que os recursos tecnológicos podem oferecer para estudantes que apresentem esse perfil e que necessitem de uma ferramenta que possibilite que se comuniquem.
Adaptação transcultural e validação de instrumentos de coleta de dados na educação especial
Authors: Pedro Ketilin Mayra , Marques Ogeda Clarissa Maria
Published: July 2023

A adaptação transcultural e a validação de instrumentos de coleta de dados configuram-se como atividades complexas e que precisam ser sistematizadas, para que o rigor científico e metodológico seja garantido, propiciando assim maior confiabilidade e fidedignidade ao processo. Neste contexto, o objetivo do presente estudo consistiu em analisar produções científicas sobre adaptação transcultural e validação de instrumentos no contexto da Educação Especial. Para tanto, realizou-se uma revisão de literatura na Scientific Electronic Library Online, Biblioteca Virtual em Saúde e o Portal de Periódicos da CAPES. Como material de apoio para análise foi utilizado o Preferred Reporting Items for Systematics Review and Meta-Analysis (PRISMA), após a análise, realizada em quatro etapas, obteve-se um total de 14 produções. Verificou-se que não há uma produção acadêmica expressiva na área, o que pode indicar uma carência de instrumentos validados e fidedignos no âmbito da Educação Especial. Constatou-se uma maior prevalência de estudos cujos instrumentos enfocaram as deficiências em geral e que contemplaram uma abordagem quantitativa para fins de tratamento e análise dos dados. Ressalta-se que os autores dos artigos selecionados que aplicaram os instrumentos na população-alvo, em sua maioria, contemplaram amostras significativas, o que proporciona maior fidedignidade ao processo de adaptação transcultural e validação. Evidenciou-se a importância de novas pesquisas na área que explorem o mérito metodológico desse tipo de pesquisa, a fim de conhecer de modo mais profundo a qualidade dos instrumentos aplicados nos estudos nacionais no âmbito da Educação Especial.
Indicadores educacionais e escolarização de alunos com deficiência múltipla na baixada fluminense
Authors: Antonioli Camyla , Pletsch Márcia Denise , Eisenberg Zena
Published: July 2023

Este artigo discute a escolarização de alunos com deficiência múltipla decorrente da Síndrome Congênita do Zika Vírus (SCZV) na Baixada Fluminense/RJ. Inicialmente, foi realizado levantamento de dados estatísticos do censo escolar do período de 2018 até 2022. Em seguida, entrevistamos seis profissionais da educação de uma escola pública de Educação Infantil de uma rede municipal de Eeucação da Baixada Fluminense/RJ. Por fim, foram também observadas 2 crianças de cinco anos diagnosticadas com SCZV. Os dados apontam para um aumento anual de matrículas de alunos com deficiência múltipla em classes comuns em escolas desta região. Igualmente, evidencia que estes números poderiam ser mais expressivos, considerando que existem crianças com SCZV que residem nesta região e que ainda não estão nas escolas, apesar da idade. No que se refere à inclusão educacional dessas crianças, o artigo foca na chegada delasà escola, a relação com os colegas e a participação nas atividades escolares. Por fim, apresenta argumentos sobre a relevância de ações intersetoriais entre educação, saúde e assistência social para a promoção do atendimento integral dessas crianças focando na escolarização, melhora da condição de saúde e bem-estar.
Lexical Priming Effects According to the Priming Type and Word Order Canonicity on Sentence Production in Persons with Aphasia: An Eye-Tracking Study
Authors: Cho Su Jeong , Sung Jee Eun , Lee Jiyeon
Published: July 2023

Objectives: The purpose of the study was to examine if persons with aphasia (PWA) can use word-level information as a sentence production strategy. Specifically, we examined the effect of lexical priming on the production of passive sentences, using an eye tracking-while-speaking paradigm. Methods: Twelve PWA and twelve healthy adults (HA) described transitive action pictures in sentences following lexical (agent or theme) primes. The priming effect was calculated using both off-line (syntactic production) and real-time (eye fixations) measures. Off-line priming effects were analyzed in terms of prime type (agent vs. theme) and word order canonicity, and the on-line analyses were conducted by the prime type and five speech regions. Results: 1) PWA did not show a significant difference from the HA group in the production of passive sentences under the theme prime condition. The proportion of passives was significantly higher in the theme prime condition compared to the agent prime condition and in canonical word order versus non-canonical word order. 2) PWA showed reduced eye fixations to the theme character compared to HA and showed evenly distributed fixations to both agent and theme characters. PWA did not show reliable differences in five speech regions. Conclusion: In off-line passive production, PWA showed preserved lexical priming effects; however, they did not show a significant prime effect on eye fixations. These findings suggest that PWA have relatively intact ability to use word-level cues on syntactic production during off-line sentence production.
The Effects of a Morphological Awareness-based Intervention Program on Spelling for School-aged Children with Spelling Difficulties
Authors: Lee Youngun , Jung Kyunghee
Published: July 2023

Objectives: The purpose of this study was to investigate the effects of a spelling intervention program based on morphological awareness on school-age children’s spelling and morphological awareness abilities. Methods: A total of 3 children with spelling difficulties in 3rd to 4th grade were selected. A dictation test tool was applied, focusing on words with aspirated consonants and ‘ㅎ’ (/h/) deletion; and consisting of single words, compound words, and derivative words. A multi-intermittent baseline design methodology including pre-, post-, and maintenance procedures was applied, and the intervention period was 2-3 times a week for 5-6 weeks, for a total of 16 sessions. Results: First, it was found that the spelling intervention effect focusing on aspirated and ‘ㅎ’ deletion of children with spelling difficulties based on morphological awareness ability resulted in improved performance compared to the baseline and was maintained 2 weeks after the intervention. Second, as a result of the spelling intervention based on morphological awareness ability, it was found that the morphological awareness ability of children with poor writing skills improved compared to the baseline and was maintained even 2 weeks after the intervention. Conclusion: The results of this study suggest that morphological awareness-based spelling interventions can be used for evidence-based spelling education for children with spelling difficulties.
Comparison of Patients' Satisfaction Between 2-dimensional and 3-dimensional Digital Smile Simulation
Authors:   Department of Restorative Dentistry and Periodontology, Faculty of Dentistry, Chiang Mai University, Thailand, Ariyakriangkai Watcharaphong , Mahasup Sorawee ,   Private Practice, Thailand, Chatiketu Piyanart ,   Department of Family and Community Dentistry, Faculty of Dentistry, Chiang Mai University, Thailand, Jittidecharaks Sumana ,   Department of Restorative Dentistry and Periodontology, Faculty of Dentistry, Chiang Mai University, Thailand
Published: July 2023

Objectives: To compare 2-dimensional (2D) and 3-dimensional (3D) smile simulation techniques from the perspective of patient preferences in comfort during data collection and the simulation outcome. Methods: Twenty subjects (10 males and 10 females) with no experience with smile simulation participated in this study. Data collection was performed by using a DSLR camera (Nikon, Tokyo, Japan) for dentofacial photography, an intraoral scanner (3-Shape, Copenhagen, Denmark) for an oral scanning file, and a tablet device (iPad, Apple, CA, USA) for smile video recording. The subjects’ perceptions of comfort towards each data collection process were evaluated using a standardized questionnaire. A week later, both 2D and 3D smile simulation outcomes were presented to participants, and subjects’ preferences toward the simulation outcomes were evaluated. Statistical analyses were performed with Wilcoxon Signed Ranks Test and the one-sample chi-square test. Results: A statistical implication presented the significant difference between 2D and 3D subjects' satisfaction in terms of time consumption for data gathering. The results showed that 90% of subjects were satisfied with 2D simulation rather than 3D simulation due to time (p=0.002). For satisfaction of the simulation outcome, there was a significant difference in the statistical implication (p<0.05). Even though preference and recommendation were significantly different factors, the subjects' overall satisfaction levels were not significantly different (p=0.74). Conclusions: Although the satisfaction of recruited individuals in the 2D simulation was higher than that in the 3D simulation during the data collection process, there was no difference in patients' preferences between the 2D and 3D outcomes.
Case Report: Prosthesis (Complete Denture) for Communication and Behavioral Impaired Dementia Patient
Authors:   Intercountry Centre for Oral Health, Department of Health, Ministry of Public Health, Thailand, Gavila Patcharaporn ,   Master’s Degree Student of Geriatric Dentistry and Special Patients Care (International program), Faculty of Dentistry, Chulalongkorn University, Thailand., Komin Orapin ,   Department of Prosthodontics, Faculty of Dentistry, Chulalongkorn University, Thailand.
Published: July 2023

Aims: To describe the procedures for complete denture fabrication in dementia and behavioral impairment patient and how to manage the case holistically. Methods and Results: The patient was a 77-year-old woman diagnosed with moderate dementia, Alzheimer’s disease with Behavioral and Psychological Symptoms of Dementia. The patient lost her previous complete dentures. She had signs of agnosia, communication problems and behavioral control. These aspects increased the difficulty in her daily life activities and in providing dental treatment. Our goal was to restore her oral function and to improve her overall general health by fabricating new complete dentures. An online consultation was used to oversee the behavioral management, adaptation in posture, and techniques in prosthodontic procedures between the postgraduate dental student providing this treatment and the prosthodontic specialist in an academic institute while they were in different places. The dental treatment in this case was provided holistically and patient-centered, the dental treatment outcomes were achieved through the follow-up visits. Conclusions: This case study revealed that a dementia patient could receive appropriate dental treatment in cooperation with the care team to maintain her oral health function. Behavioral management could be performed using non-pharmacological methods. After delivering the denture, the patient’s nutritional status and the quality of life largely depends on the caregiver when the dementia progresses.
University Students’ Internet Addiction and the Relationship Between Online Gaming and Family Function in Karachi, Pakistan
Authors:   Department of Family and Community Medicine, College of Medicine,  University of Hail, Kingdom of Saudi Arabia., Zafar Mubashir
Published: July 2023

Internet addiction in the student population is a chronic social issue in Pakistan. Parental supervision is required to counter the issue. This study identifies an association between online gaming disorder and family functions by studying university students in Karachi, Pakistan. It is a cross-sectional study and 350 university students were selected through a multi-stage stratified sampling technique. A validated and structured questionnaire assessed family functioning and internet addiction. Data was analyzed using a multivariate logistic regression to identify associations between family function and online gaming disorders. In total, 66 per cent of students were found to be addicted to videogames and 39 per cent of students were deficient in their role in the family. The decreased problem solving skills (Adjusted Odd Ratio AOR 2.02, 95 per cent CI 1.35-5.96, p-value 0.002), decreased roles in the family (AOR 2.99, 95 per cent CI 1.23-5.75, p-value 0.004) and bad communication skills (AOR 0.91, 95 per cent CI 0.59-2.94, p-value 0.567) were associated with severe online gaming disorder. This study reveals a strong association between disrupted family functions and internet addiction and provides new evidence on the complex interaction between individuals and interpersonal risk factors involved in addiction among young adults. Keywords: Games, Family, Internet Addiction, Students, University
The Effect of Optimum Photoperiod from Blue LED Light on Growth of Chlorella Vulgaris in Photobioreactor Tank
Authors:   Department of Agriculture and Resources, Faculty of Natural Resources and Agro-Industry, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon 47000, Thailand., Kamolrat Narong , Kamuang Settakorn ,   Department of Electric Engineering and Computer, Faculty of Science and Engineering, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon 47000, Thailand, Khamket Thiamthep ,   Department of Electric Engineering and Computer, Faculty of Science and Engineering, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon 47000, Thailand, Sangmek Pichasit ,   Department of Agriculture and Resources, Faculty of Natural Resources and Agro-Industry, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon 47000, Thailand., Sitthaphanit Suphasit ,   Department of Agriculture and Resources, Faculty of Natural Resources and Agro-Industry, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon 47000, Thailand.
Published: July 2023

Abstract Study for investigated the optimum photoperiod from blue LED light for the growth of Chlorella vulgaris in culture tank. Photoperiods from blue LED Light (Light/Dark) were set up at 24:0, 16:8 and 12:12 h. The initial number of C. vulgaris cells was 1.6 x 105 ± 0.12 cells mL-1. Culture medium was using commercially available fertilizers. After 17 days of cultivation, the results showed that the 24:0 h photoperiod had better growth of algae than 16:8 and 12:12 h, with maximum number of cells of 1.64 x 107 ± 0.23 cells mL-1 specific growth rate (SGR) was 0.17 ± 0.05, -0.06 ± 0.11 and -0.19 ± 0.1% day-1 with statistically significant differences (P < 0.05) in day 5 of cultivation. The stationary phase continued up to day 3 of cultivation, between the treatment. The optimum temperature for growth ranged from 35.5–38.5°C. The results showed that blue LED lighting at 24:0 h is the optimum photoperiod for cultivation of C. vulgaris. Keywords: Photobioreactor tank, Photoperiod, Blue LED light, Chlorella vulgaris, Growth rate
Development of Mucoadhesive Chitosan-Iodoacetamide Buccal Tablets for Local Delivery of Dextromethorphan
Authors:   Pharmaceutical Development of Green Innovations Group (PDGIG), Department of Industrial Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand, Myat Yin Yin , Vollrath Mont Kumpugdee ,   Faculty of Pharmaceutical and Chemical Engineering, Berliner Hochschule für Technik, 13353 Berlin, Germany, Sahatspan Nitjawan ,   Pharmaceutical Development of Green Innovations Group (PDGIG), Department of Industrial Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand,   Department of Materials Science and Engineering, School of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Rayong, 21210, Thailand, Ngawhirunpat Tanasait ,   Pharmaceutical Development of Green Innovations Group (PDGIG), Department of Industrial Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand, Pornpitchanarong Chaiyakarn ,   Pharmaceutical Development of Green Innovations Group (PDGIG), Department of Industrial Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand, Patrojanasophon Prasopchai ,   Pharmaceutical Development of Green Innovations Group (PDGIG), Department of Industrial Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand
Published: July 2023

Abstract This study aimed to synthesize a chitosan (CHI) derivative, chitosan-iodoacetamide (CHI-IA), with enhanced mucoadhesive properties and develop buccal mucoadhesive tablets of CHI-IA for local delivery of dextromethorphan (DXT). Mucoadhesive CHI-IA was synthesized by a chemical reaction between CHI and iodoacetic acid (IA) in different weight ratios. The synthesized CHI-IA was characterized by Fourier-transformed infrared spectroscopy (FT-IR) and nuclear magnetic resonance spectroscopy (NMR) to confirm the chemical structure and assure successful synthesis. DXT was selected as the model drug to be incorporated into the matrix tablet to develop mucoadhesive buccal cough relief tablets. The mucoadhesive strength of the CHI-IA tablets was determined by a texture analyzer. Moreover, the drug content and the release characteristics of DXT from the mucoadhesive tablets were evaluated. The FT-IR and NMR spectra of CHI-IA indicated the conjugation of IA on the structure of CHI. The CHI-IA tablets exhibited a 4-time increase in mucoadhesion force compared with that of unmodified CHI. Moreover, a gradual release of DXT from the tablets was observed, and the release kinetics best fit with the Higuchi model (R2 = 0.9912). Therefore, the CHI-IA could be applied as the mucoadhesive carrier system for drug delivery. Keywords: Chitosan, Iodoacetic acid, Mucoadhesive, Buccal tablets, Dextromethorphan
Effects of Arm Swing Exercise Program on HbA1C and Nutritional Status in Adults and Older Adults with Type 2 Diabetes: A Quasi-Experimental Study
Authors:   Ramathibodi School of Nursing, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand, Terathongkum Sangthong , Kittipimpanon Kamonrat ,   Ramathibodi School of Nursing, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
Published: July 2023

Abstract Regular physical activity is recommended for managing type-2 diabetes to achieve optimal glycemic control. Limited studies compared the effects of exercise between adults and older adults with type-2 diabetes. This quasi-experimental aim to investigate the effects of the Arm Swing Exercise Program on HbA1C and nutritional status among four groups of adults and older adults with type-2 diabetes. Eighty eligible participants were assigned to the experimental groups (20 adults and 21 older adults) receiving the 12-week Arm Swing Exercise Program 30 minutes/day 5 day/week along with standard care, whereas the control groups (17 adults and 22 older adults) received standard care. Data were obtained, using the demographics questionnnaire, HbA1C, and nutritional status including waist circumference, body mass index, visceral fat, and skeletal muscle, before and after the Program. Paired t-tests, ANCOVA, and ANOVA were used for data analysis. The findings revealed no significant difference in HbA1C, waist circumference, body mass index, visceral fat, and skeletal muscle after receiving the Program between adults and older adults in the experimental groups. Older adults in the experimental group had significantly lower waist circumference than older adults in the control group, while adults in the experimental group had significantly lower waist circumference than adults and older adults in the control groups. This program was effective in only waist circumference reduction. Thus, nurses should encourage people with type-2 diabetes to continuously practice both the arm swing exercise and standard care to achieve glycemic control and better nutritional status. Further study should have more participants using randomized controlled trials and control other sensitive outcomes to the arm swing exercise. Keywords: Arm swing exercise, Hemoglobin A1C, Nutritional status, Adults, Older adults, exercise
Microscopical and phylogenetic analysis of Theileria annulata in Iraqi local breed cattle
Authors:   Department of Microbiology, College of Veterinary Medicine , University of Al-Qadisiyah, Al-Diwaniyah, 58001, Iraq, Albayati Hadeel Hadi , Al Khafaji Alaa Mohammed ,   Department of Microbiology, College of Veterinary Medicine , University of Al-Qadisiyah, Al-Diwaniyah, 58001, Iraq, kamel Amal ,   College of Medical & Health Technology, Middle technical university, Baghdad, 10001, Iraq, Al-karagoly Hassan ,   Department of Internal and Preventive Medicine, College of Veterinary Medicine, University of Al-Qadisiyah, Al-Diwaniyah, 58001, Iraq
Published: July 2023

The development of cattle industry in Iraq and its neighboring countries may be hampered by Theileria annulata (T. annulata) infection. In the present work, the cytochrome b gene (cyt-b) sequences were used to infer the phylogenetic relationships of T. annulata. Fifty blood samples collected randomly from 10 farms of Iraqi local breed cattle in Al-Diwaniyah province were analyzed for piroplasm using microscopic and molecular techniques. Microscopic examination revealed that 37 (74%) of the 50 blood samples examined were infected. In addition, the PCR test showed that 23 (62.2%) of the 37 blood samples (which tested positive (microscopically) were positive. The analysis of the cyt-b 1092 bp gene of T. annulata reported the presence of six genetically related clones. These six clones have been deposited in GenBank as [ON706262, ON706263, ON706264, ON706265, ON706266, and ON706267], and when compared to the T. annulata cyt-b gene (XM949625) from the GenBank database, a unique polymorphism at sixteen sites was discovered. Furthermore, the alignment of our amino acid sequences with the reference sequence reveals thirteen non-synonymous mutations in codons 11, 22, 33, 63, 103, 128, 130, 129, 172,178, and 190, and three silent mutations in codons 124, 128, and 275. Moreover, phylogenetically, our study clones were related to Iraqi, Indian, and Turkish clones. In conclusion, depending on the phylogenetic analysis the current study identified six T. annulata parasite isolates in Iraqi local breed cattle that were genetically related to the Indian, Iraqi, and Turkish clones.
Effects of organic acid and garlic powder supplementations in the diet on growth and intestinal microflora of the exotic Tam Hoang chickens
Authors:   Department of Animal Science, College of Agriculture, CanTho University, CanTho 900000, Vietnam, Thuy Nguyen Thi , Phuong Le Thanh ,   Vietswan Poultry Production Joint Stock Company, Binh Duong 820000, Vietnam, Nguyen Cong Ha ,   Department of Food Technology, College of Agriculture, CanTho University, CanTho 900000, Vietnam
Published: July 2023

A study was carried out to evaluate the effect of diet’s organic acid (OG) and garlic powder (GP) on the growth, carcass quality, and intestinal microflora of Tam Hoang chickens. The experiment consisted of three treatments and four replications in a completely randomized design; each replication was a pen (20 chickens/pen), and males and females were raised separately. The treatmentswere:1/Cont: Basal diet (BD) no supplementation; 2/OG: BD + 1g Poulacid /kg feed; 3/GP: BD + 1 g garlic powder/kg feed. Results showed that chickens fed Cont (1451 g /head) had lower final live weight than those having OG (1568 g/head) and GP (1521 g/head/day). So, the average daily gain (ADG) of chickens in Cont (16.8 g/head/day) and GP (17.7 g/head/day) were lower than in OG (18.2 g/head/day). Average daily feed intake (ADFI) was similar in all treatments. Therefore, the feed conversion ratio (FCR) of chickens fed OG (3.04 kg feed/kg gain) was better than that in Cont (3.32 kg feed/kg gain). The density of Salmonella bacteria was not detectable in chicken feces at the 4th week age but became positive in Cont and GP treatments at the 10th week age. Supplementation of OG and GP reduced E. coli and Clostridium perfringens in the feces compared to control chickens at the 4th and 10th week age. In conclusion, adding OG or GP at the same dose (1g/kg feed) in Tam Hoang chicken diets improved ADG, FCR, and reduced E. coli and Clostridium perfringens densities in the feces compared to control chickens
Biofilm: a platform for the evaluation of antimicrobial treatments and prevention against Mycoplasma bovis infection
Authors:   College of Veterinary Science and Medicine, Central Luzon State University, Science City of Muñoz 3120, Nueva Ecija, Philippines, Tubalinal Gabriel Alexis SP. ,   Biosafety and Environment Section, Philippine Carabao Center, Science City of Muñoz 3120, Nueva Ecija, Philippines, Garcia Gemerlyn G. ,   College of Veterinary Science and Medicine, Central Luzon State University, Science City of Muñoz 3120, Nueva Ecija, Philippines, Mingala Claro N. ,   Biosafety and Environment Section, Philippine Carabao Center, Science City of Muñoz 3120, Nueva Ecija, Philippines
Published: July 2023

Mycoplasma bovis is an important pathogen in large ruminants that causes various clinical pathologies with great economic impact. Though mycoplasmas were thought to have gone reductive evolution that led to the loss of genetic materials leading to the marked absence of cell wall and canonical virulence factors, adaptation made by some M. bovis isolates include production of biofilms to survive, evade host immune response, persists in a biotic environment and may mount related responses that render chemotherapy ineffective. In this review, topics on biofilms commonly produced by M. bovis isolates were discussed to view its pathogenicity. Reports that describe the involvement of variable surface antigensin biofilm production of M. bovis are also presented. This information invites interest on biofilms anchored on studies where it can be developed to be utilized as platforms for the evaluation of antimicrobial treatments and for the identification of a preventive and control strategy against Mycoplasma bovis infection.
Caprine Roundworm Nematode Resistance to Macrocyclic Lactones in Northeastern Thailand
Authors:   Division of Livestock Medicine, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen 40002 Thailand, Rerkyusuke Sarinya , Lamul Pichayawadee ,   Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen 40002 Thailand, Thipphayathon Chanoknan ,   Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen 40002 Thailand, Kanawan Kamonwan ,   Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen 40002 Thailand, Porntrakulpipat Sarthorn ,   Division of Livestock Medicine, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen 40002 Thailand
Published: July 2023

Roundworm nematodes are a significant problem in goat meat farming worldwide. These parasites can cause production losses, reduce feed efficiency and compromise animal health and welfare. Macrocyclic lactones (MLs) are common anthelmintic drugs to treat roundworm nematode infection in livestock. The objective of study was to detect roundworm resistance to MLs in meat goats in Northeast Thailand. One hundred and nineteen goats from 6 herds were studied from June to December 2022. Each herd was randomly allocated to control (n=21), epinomectin (n=34), ivermectin (n=40) and moxidectin (n=24) groups. Anthelmintic resistance (AR) was assessed based on the Fecal Egg Count Reduction Test (FECRT) and larva culture at pre-treatment (D0) and 14 days post-treatment (D14). Prevalence of Strongyle nematodes and Trichuris spp. infection was 100% (6/6 herd), and 66.7% (4/6 herd), respectively. The number of Strongyle eggs was significantly reduced in the eprinomectin group (p < 0.01). In contrast, the ivermectin group was significantly increased (p < 0.01). The prevalence of ML resistance of Strongyle nematodes and Trichuris spp. was 83.3% (5/6 herd) and 25.0% (1/4 herd), respectively. The dominant larva was Haemonchus contortus at pre- and post-treatment in every herd. This study demonstrated the presence of ML resistant Strongyle nematodes as H. contortus and Trichuris spp. in this area. To reduce ML resistance it can be useful to use drugs in combination or rotate MLs with other classes of anthelmintics or in targeted treatment programs and integrated parasite management strategies. Consequently, the efficacy of anthelmintic drugs in small ruminants needs to be monitored and surveilled in this area.
Improved Antibiotic Activity from Streptomyces monomycini strain RVE129 Using Classical and Statistical Design of Experiments
Authors: Elias Firew , Muddada Sudhamani , Muleta Diriba , Tefera Belachew
Published: July 2023

Many bioactive secondary metabolites with intriguing antibacterial, antiviral, and anticancer properties have been produced by Streptomyces species. The objective of this work is to use conventional and statistical techniques to improve the antibiotic production medium of Streptomyces monomycini RVE129, which was isolated from rhizospheric soil in Hawassa, Ethiopia. The main media components were chosen using the one factor at a time method and the Plackett-Burman design, which was then, further, optimized using the Box-Behnken Design for increased antibiotic production. On ISP4 medium (10 g/L starch, 1 g/L NaCl, 1 g/L MgSO4.7H2O, 2 g/L (NH4) 2SO4, 2 g/L CaCO3and 1 g/L K2HPO4, 0.1 g/L FeSO4·7H2O, 0.1 g/L MnCl2·4H2O, 0.1 g/L ZnSO4·7H2O), S. monomycini RVE129 produced the greatest amount of antibiotics. Starch and soybean meal were found to be the best sources of carbon and nitrogen for the strainRVE129. During the eighth day of incubation under shaking conditions, the best conditions for antibiotic synthesis were determined at a temperature of 30°C and a pH of 7.5. Plackett-Burman design identified K2HPO4, starch, and soybean meal as having the highest influence on antibiotic synthesis with a confidence level above 95%. The yield of producing antibiotics increased by 24.30% when the concentration of critical variables was further improved by using the Box-Behnken Design of the Response Surface approach. The optimum concentration was 20 g/L starch, 7.5 g/L s oybean meal, and 1.25 g/L K2HPO4. To the best of our knowledge, this is the first investigation into medium optimization for the production of the antibiotic from S. monomycini RVE129.
An Open-Label, Randomized, Parallel-Group Study to Assess the Safety, Efficacy, and Tolerability of Tapentadol Versus Tramadol in Outpatients with Moderate to Severe Chronic Low Back Pain at a Tertiary Care Hospital in South India
Authors: Naveen S , Elango P , S Ramya
Published: July 2023

Low back pain is a very common musculoskeletal symptom with multifactorial aetiology. Aims and objectives: Our study aimed at comparing the efficacy, safety, and tolerability of tapentadol versus tramadol in out-patients with moderate to severe chronic low back pain. Fifty-two patients with a diagnosis of chronic low back pain for > 3 months were randomly assigned to receive either a 50 mg tablet of tapentadol (twice daily) or 50 mg tablet of tramadol (twice daily) for 1 week. The mean (±SD) difference in the reduction of pain (at end of 1 week) between the two groups was compared employing an independent student t-test for difference in mean values separately for the Visual Analogue Scale (VAS) and Roland Morris Disability Questionnaire (RMDQ) scores. The frequency of the different adverse events between the two groups was compared employing Chi-square test. Except for VAS scores, the baseline demographic parameters of the two groups were comparable. The study found that tapentadol reduced VAS and RMDQ scores more than tramadol (statistically significant p<0.001) between baseline and the end of week 1. Regarding safety and tolerability, the tapentadol group experienced nausea/vomiting and dizziness/somnolence more frequently than the tramadol group, with p-values of 0.011 and 0.001 respectively. Both groups experienced similar rates of headache and constipation, with p-values of 0.668 and 0.610, respectively. When compared to tramadol (50 mg twice daily), tapentadol (50mg twice daily) was found to significantly improve pain and disability in patients with moderate to severe chronic low back pain, while tapentadol had greater frequencies of side effects like nausea, vomiting, dizziness, and somnolence.
Celery Ethanol Extract Prevents Renal Ischemia-Reperfusion Injury via Increasing Nitrite Oxide and Superoxide Dismutase
Authors: A Afifah , Muflikhah Khusnul , Sutrisna Eman , Pribadi Fajar Wahyu , Rujito Lantip , Avinda Tzania el Izz , Hasan Ahmad Musafi , Mukti Kresna , Haryadi Dias Rudi
Published: July 2023

Background: Acute kidney injury (AKI) is one of the health problems. Kidney ischemia-reperfusion injury (IRI) contributes to pathological conditions of AKI. An imbalance between renal vasoconstriction and vasodilatation mediators was played a role in IRI and its chronic complications. Stress oxidative and inflammation were major pathomechanism of IRI. Administration of celery ethanol extract is one of the efforts to prevent kidney damage caused by IRI. This study aimed to investigate the time effect of celery ethanol extract administration on inhibition of kidney IRI. Methods: Twenty male Sprague Dawley rats with a weight range of 190-210 g were selected for the study. The rats were divided into five groups randomly: sham operation (SO, n=4) group, IRI group (ischemia-reperfusion injury, n=4), IRI+S7 (celery ethanol extract 1000 mg/kg BW 7 days orally+ischemia-reperfusion injury, n=4), IRI+S14 (celery ethanol extract 1000 mg/kg BW 14 days orally+ischemia-reperfusion injury, n=4), IRI+S28 (celery ethanol extract 1000 mg/kg BW 28 days orally+ischemia-reperfusion injury, n=4). Serum samples were collected for creatinine serum, NO, SOD, and TNF-α measurement. mRNA expression of ET-1 and ETAR was quantified using reverse transcriptase-PCR. Result: Serum creatinine, NO, and SOD level in rats with celery ethanol extract 1000 mg/kg BW for 7 and 14 days administration before IRI induction lower than IRI group (p<0.05) and increase in 28 days administration. Meanwhile, the TNF-α level, ET-1, and ETAR gen expression lower than the IRI group but not significantly different (p>0.05). Conclusion: Administration of celery ethanol extract 1000 mg/kg BW for 7 days and 14 days prevents renal ischemia-reperfusion injury via increasing NO and SOD. Administration more than 28 days is not recommended.
Neurodevelopmental Manifestations and Birth Defects in Prader-Willi Syndrome: Findings from a Study in Western Ukraine
Authors: M Drobchak , N Kitsera , Z Osadchuk , N Kech , M Bondarenko , R Kozovyi
Published: July 2023

Prader-Willi syndrome (PWS) is a genetic disease characterized by mental retardation, as well as autism spectrum disorders, obesity and mood disorders. The aim of our study was to research a spectrum of genetic heterogenity and different clinical neurodevelopmental manifestations. Materials and methods: clinical, molecular, genetic and psychological methods were used. We observed 9 children (5 boys and 4 girls) with Prader-Willi syndrome from Lviv and Ivano-Frankivsk regions (Western Ukraine) who were diagnosed and followed-up at the Institute of Hereditary Pathology, National Academy of Medical Sciences of Ukraine, Lviv, for 4 years (2019–2022) and underwent molecular genetic testing. The ages of children ranged from 1 month to 7 years, with the mean value amounting to 3.6 years of age. Results: Our study revealed that 6 (66.7%) out of 9 children with PWS had birth defects. At ultrasound during pregnancy, we observed certain clinical features of the fetus, including fetal intrauterine development delay –5 (55.5%), and higher nuchal translucency measurement – 3 (33.3%). According to the checklist of autism spectrum disorders (CASD), 3 of the examined children with autism syndrome were at risk and required further monitoring, while 5 children scored 18-20 points, which indicated the presence of autistic spectrum and required in-depth monitoring during diagnosis. Stereotypical and repetitive play as a manifestation of problems with social interaction was observed in 3 boys with PWS. In our study, parents had no complaints about aggressive behavior in children with this syndrome. Conclusions: In cases if the children have signs of autism or developmental delay, they should undergo genetic counseling.