bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of Membrane-Associated Progesterone Receptor Component-2 (MAPRC2) from Trichinella spiralis and Its Interaction with Progesterone and Mifepristone
Authors: Aleem Muhammad Tahir , Shi Jiawen , Yu Zhengqing , Wen Zhaohai , Zhang Yang , Liang Meng , Lakho Shakeel Ahmed , Haseeb Muhammad , Ali Haider , Hassan Muhammad Waqas , Song Xiaokai , Li Xiangrui , Xu Lixin , Yan Ruofeng
Published: August 2021

Trichinellosis is a foodborne zoonotic disease caused by Trichinella spp., including Trichinella spiralis. In the present study, T. spiralis membrane-associated progesterone receptor component-2 (Ts-MAPRC2) gene was cloned and characterized using protein sequencing analysis. Furthermore, the expression, purification, immunoblot assay, binding ability with progesterone antibody, and immunofluorescence assay were performed. A direct effect of progesterone (P4) and mifepristone (RU486) on the Ts-MAPRC2 gene was determined using in vitro cell culture that showed different expression levels at all developmental stages (muscle larvae (ML), female adult worm (F-AL), male adult worm (M-AL), and newborn larvae (NBL)). Subsequently, the in vitro phenotypic effects of P4, RU486, and rTs-MAPRC2-Ab on F-AL and ML stages were measured. Later, the in vivo phenotypic effect and relative mRNA expression of mifepristone on the F-AL stage were studied. Our results revealed that the Ts-MAPRC2 gene is critical to maintaining pregnancy in the female adult worm (F-AL) of T. spiralis. The 300 ng/mL of P4 and 100 ng/mL of RU486 showed downregulation of the Ts-MAPRC2 gene in F-AL (p ≤ 0.05). This plays an important role in abortion and possibly decreases the worm burden of T. spiralis in the host. Only 30 ng/mL P4 showed significant upregulation in F-AL (p ≤ 0.05). The current study provides new insights regarding the antihormone (P4 and RU486) drug design and vaccine therapy of recombinant (rTs-MAPRC2) protein as well as their combined effects to control T. spiralis infection.
Advances in Engineered Polymer Nanoparticle Tracking Platforms towards Cancer Immunotherapy—Current Status and Future Perspectives
Authors: Thangam Ramar , Patel Kapil D. , Kang Heemin , Paulmurugan Ramasamy
Published: August 2021

Engineering polymeric nanoparticles for their shape, size, surface chemistry, and functionalization using various targeting molecules has shown improved biomedical applications for nanoparticles. Polymeric nanoparticles have created tremendous therapeutic platforms, particularly applications related to chemo- and immunotherapies in cancer. Recently advancements in immunotherapies have broadened this field in immunology and biomedical engineering, where “immunoengineering” creates solutions to target translational science. In this regard, the nanoengineering field has offered the various techniques necessary to manufacture and assemble multifunctional polymeric nanomaterial systems. These include nanoparticles functionalized using antibodies, small molecule ligands, targeted peptides, proteins, and other novel agents that trigger and encourage biological systems to accept the engineered materials as immune enhancers or as vaccines to elevate therapeutic functions. Strategies to engineer polymeric nanoparticles with therapeutic and targeting molecules can provide solutions for developing immune vaccines via maintaining the receptor storage in T- and B cells. Furthermore, cancer immunotherapy using polymeric nanomaterials can serve as a gold standard approach for treating primary and metastasized tumors. The current status of the limited availability of immuno-therapeutic drugs highlights the importance of polymeric nanomaterial platforms to improve the outcomes via delivering anticancer agents at localized sites, thereby enhancing the host immune response in cancer therapy. This review mainly focuses on the potential scientific enhancements and recent developments in cancer immunotherapies by explicitly discussing the role of polymeric nanocarriers as nano-vaccines. We also briefly discuss the role of multifunctional nanomaterials for their therapeutic impacts on translational clinical applications.
The Rise and Fall of a Local SARS-CoV-2 Variant with the Spike Protein Mutation L452R
Authors: Mor Orna , Mandelboim Michal , Fleishon Shay , Bucris Efrat , Bar-Ilan Dana , Linial Michal , Nemet Ital , Kliker Limor , Lustig Yaniv ,   Israel National Consortium for SARS-CoV-2 Sequencing, Mendelson Ella S. , Zuckerman Neta S.
Published: August 2021

Emerging SARS-CoV-2 variants may threaten global vaccination efforts and the awaited reduction in outbreak burden. In this study, we report a novel variant carrying the L452R mutation that emerged from a local B.1.362 lineage, B.1.362+L452R. The L452R mutation is associated with the Delta and Epsilon variants and was shown to cause increased infection and reduction in neutralization in pseudoviruses. Indeed, the B.1.362+L452R variant demonstrated a X4-fold reduction in neutralization capacity of sera from BNT162b2-vaccinated individuals compared to a wild-type strain. The variant infected 270 individuals in Israel between December 2020 and March 2021, until diminishing due to the gain in dominance of the Alpha variant in February 2021. This study demonstrates an independent, local emergence of a variant carrying a critical mutation, L452R, which may have the potential of becoming a variant of concern and emphasizes the importance of routine surveillance and detection of novel variants among efforts undertaken to prevent further disease spread.
Risk Factors Associated with the Clinical Outcomes of COVID-19 and Its Variants in the Context of Cytokine Storm and Therapeutics/Vaccine Development Challenges
Authors: Hanna John , Tipparaju Padmavathi , Mulherkar Tania , Lin Edward , Mischley Victoria , Kulkarni Ratuja , Bolton Aliyah , Byrareddy Siddappa N. , Jain Pooja
Published: August 2021

The recent appearance of SARS-CoV-2 is responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic and has brought to light the importance of understanding this highly pathogenic agent to prevent future pandemics. This virus is from the same single-stranded positive-sense RNA family, Coronaviridae, as two other epidemic-causing viruses, SARS-CoV-1 and MERS-CoV. During this pandemic, one crucial focus highlighted by WHO has been to understand the risk factors that may contribute to disease severity and predict COVID-19 outcomes. In doing so, it is imperative to understand the virology of SARS-CoV-2 and the immunological response eliciting the clinical manifestation and progression of COVID-19. In this review, we provide clinical data-based analyses of how multiple risk factors (such as sex, race, HLA genotypes, blood groups, vitamin D deficiency, obesity, smoking, and asthma) contribute to the inflammatory overactivation and cytokine storm (frequently seen in COVID-19 patients) with a focus on the IL-6 pathway. We also draw comparisons to the virulence and pathophysiology of SARS and MERS to establish parallels in immune response and discuss the potential for therapeutic approaches that may limit disease progression in patients with higher risk profiles than others. Moreover, we cover the latest information on approved or upcoming COVID-19 vaccines. This paper also provides perspective on emerging variants and associated opportunistic infections such as black molds and fungus that have added to mortality in some parts of the world, such as India. This compilation of existing COVID-19 studies and data will provide an excellent referencing tool for the research, clinical, and public health communities.
Nervous and Muscular Adverse Events after COVID-19 Vaccination: A Systematic Review and Meta-Analysis of Clinical Trials
Authors: Chen Jiaxin , Cai Yuangui , Chen Yicong , Williams Anthony P. , Gao Yifang , Zeng Jinsheng
Published: August 2021

Background: Nervous and muscular adverse events (NMAEs) have garnered considerable attention after the vaccination against coronavirus disease (COVID-19). However, the incidences of NMAEs remain unclear. We aimed to calculate the pooled event rate of NMAEs after COVID-19 vaccination. Methods: A systematic review and meta-analysis of clinical trials on the incidences of NMAEs after COVID-19 vaccination was conducted. The PubMed, Medline, Embase, Cochrane Library, and Chinese National Knowledge Infrastructure databases were searched from inception to 2 June 2021. Two independent reviewers selected the study and extracted the data. Categorical variables were analyzed using Pearson’s chi-square test. The pooled odds ratio (OR) with the corresponding 95% confidence intervals (CIs) were estimated and generated with random or fixed effects models. The protocol of the present study was registered on PROSPERO (CRD42021240450). Results: In 15 phase 1/2 trials, NMAEs occurred in 29.2% vs. 21.6% (p < 0.001) vaccinated participants and controls. Headache and myalgia accounted for 98.2% and 97.7%, and their incidences were 16.4% vs. 13.9% (OR = 1.97, 95% CI = 1.28–3.06, p = 0.002) and 16.0% vs. 7.9% (OR = 3.31, 95% CI = 2.05–5.35, p < 0.001) in the vaccine and control groups, respectively. Headache and myalgia were more frequent in the newly licensed vaccines (OR = 1.97, 95% CI = 1.28–3.06, p = 0.02 and OR = 3.31, 95% CI = 2.05–5.35, p < 0.001) and younger adults (OR = 1.40, 95% CI = 1.12–1.75, p = 0.003 and OR = 1.54, 95% CI = 1.20–1.96, p < 0.001). In four open-label trials, the incidences of headache, myalgia, and unsolicited NMAEs were 38.7%, 27.4%, and 1.5%. Following vaccination in phase 3 trials, headache and myalgia were still common with a rate of 29.5% and 19.2%, although the unsolicited NMAEs with incidence rates of ≤ 0.7% were not different from the control group in each study. Conclusions: Following the vaccination, NMAEs are common of which headache and myalgia comprised a considerable measure, although life-threatening unsolicited events are rare. NMAEs should be continuously monitored during the ongoing global COVID-19 vaccination program.
Scientific-methodological and scientific study of postgraduate and doctoral students
Authors: Markhgeym M.V.
Published: August 2021

This publication is a reviewon textbook of I.V. Ponkin and A.I. Redkina “Methodology of Scientific Research and Practical Analytics” (Moscow: Buki Vedi, 2020, 365 p.).
A note of optimism in the melody of education
Authors: Malinetskiy Georgiy Gennadievich
Published: August 2021

In the article, the author reflects on the nature of the changes in the field of education, which are associated with its active reform in the last two decades. The author insists that the development of education is the key to the development of science, and vice versa. And without science, it is impossible to build a great power and maintain its status. Being an academic scientist, the author demonstrates how the formation of the younger generation takes shape and shows the role of scientific journals in this process.
The main cultural approaches in the interpretation of the immortality phenomenon. Scientifi c and methodological materials in the "Cultural Studies" training program
Authors: Karpukhin Oleg Ivanovich , Rudakova Darya
Published: August 2021

The article demonstrates that one of the most important and original forms of embodying the issue of death and immortality is a myth, the core of which, regardless of the territorial location of the state, was the act of sacrifice and the interrelated principle of retribution. It is the myth that introduces the epistemological subject to the constructs of reality, not relying on abstract concepts and logical reasoning, but guided by visual poetized images and sensory associations. The article reveals the issue of immortality as a mythologem and as a scientific problem of many cultural concepts.
Prospects and risks of digitalization in the XXI century
Authors: Gordeev Roman Mikhaylovich
Published: August 2021

The article demonstrates that information and digital technologies play a special role in the genesis of a new technological paradigm and acceleration of technological development. The digital reality in which the humanity lives today is largely determined by the ideas that developed in the 1960s and 1970s of the twentieth century: these are the ideas of hypertext, graphical user interface, and the global information network, as well as the deriving from the above mentioned idea of the personal computer as a device with a widest range of applications in almost any area of human life. The author examines the scenarios of positive and negative future presented both in scientific literature and in works of mass culture, and shows that the future of digital civilization is determined only by the human.
Methodology of humanitarian knowledge. Mass culture: adaptive and socializing potential
Authors: Kostina Anna Vladimirovna
Published: August 2021

The author proves that despite the generally accepted point of view regarding the negative functions performed by mass culture in society, i.e., first of all, simplifying consciousness, escapist, and compensatory one, there is a number of positive functions performed by mass culture in modern society. Among them, the author highlights the ability of mass culture to construct social communities and the adaptive function that becomes necessary within the framework of non-traditional — industrial, post-industrial, and informational social structures. The material of the article may be of interest as a specific methodology for the study of socio-cultural phenomena.
On culture and Cultural Studies: reflections of a scientist
Authors: Flier Andrey Yakovlevich
Published: August 2021

The article raises the problems of ontology and social essence of culture, its definition from the author's scientific point of view, features of modern culture, the place of art in culture, as well as the issues of general prospects of cultural science and education. The original author's definition of culture as a program of group adaptive behavior of people is given.
Study on sound transmission loss modeling through simplified sealing specimens and an automotive door sealing system
Authors: Deng Guoming , Shao Jianwang , Zheng Songlin , Wu Xian
Published: August 2021

An imperfect sealing system would be the main path of the noise propagating into the interior compartment of a high-speed vehicle. The study on the sound insulation modeling of automotive door sealing systems, which involve complicated threedimensional sealing structures and gap cavities,
has attracted more and more attention. This study employs hybrid finite element–statistical energy analysis (FE-SEA) models to predict the sound transmission loss of three simplified sealing specimens and an actual automotive door sealing system. For the actual sealing system under compression,
a three-dimensional FEmodel is built to simulate the nonlinear compression, which can acquire the compressed geometries and pre-stress modal results of the seals for further prediction of the sound transmission loss. The hybrid FE-SEA method is firstly verified by the experimental result of
a double plate vibro-acoustic system and another numerical method. Several factors concerning the modeling, including the boundary conditions, the equivalent elastic modulus for the hyper-elastic rubber, the specimen length, and the structural grid size, are considered to study their impacts
on the sound transmission loss. The effects of using shell elements and using solid elements to model the sealing rubber layers are also compared. The results of this study can provide guides regarding the trade-off between the modeling efficiency and accuracy, so that it has significance
for engineering modeling, as well as the design and optimization of automotive door sealing systems.
Station facilities and noise assessment: A multilevel analysis on light rail train stations
Authors: Yildirim Yalcin , Jones Allen Diane
Published: August 2021

Noise is one of the most frequent consequences of traffic. Public transportation systems, such as the Dallas Area Rapid Transit (DART) authority provides various modes of transportation. Even though the availability of commuting service for the public is a boon to communities, mass
transit systems are potential sources of excessive sound levels in daily urban life. This article examines the nexus between the transit station facilities of light rail train (LRT) stations and noise implications at both station and neighborhood scales by studying selected LRT stations. A
multilevel linear analysis was conducted to understand the degree of train station amenities and neighborhood characteristics that affect sound levels. Using a type II sound pressure level (SPL)meter, sound measurements were obtained during the weekdays and weekends over several weeks. Upon
examining the station amenities, and built environment and sociodemographic characteristics of the neighborhood, findings of this comprehensive research reveal significant implications for sound levels. Stations with ticket vending machines and informative message boards include a higher degree
of significance on SPLs, while shelters, crew rooms, bike lockers, restrooms, and windshields are significantly and negatively associated with the noise levels. Additionally, neighborhoods with dense roads, higher speed limits, more neighborhood facilities, and a higher number of transit routes
have an increased likelihood of noise levels. Recommendations include creating transformative policies for implementation, and approaches addressing noise for transit authorities, transportation engineers, and planners are presented. Planning and engineering aspects of comfort, aesthetics,
safety, and public health, as train stations are daily use spaces for commuters and surrounding communities, should also be considered.
Optimal design of noise reduction and shape modification for traction gears of EMU based on improved BP neural network
Authors: Tang Zhaoping , Wang Min , Xiong Xiaoying , Wang Manyu , Sun Jianping , Yan Li
Published: August 2021

Under high-speed operating conditions, the noise caused by the vibration of the traction gear transmission system of the Electric Multiple Units (EMU) will distinctly reduce the comfort of passengers. Therefore, analyzing the dynamic characteristics of traction gears and reducing noise
from the root cause through comprehensive modification of gear pairs have become a hot research topic. Taking the G301 traction gear transmission system of the CRH380A high-speed EMU as the research object and then using Romax software to establish a parametric modification model of the gear
transmission system, through dynamics, modal and Noise Vibration Harshness (NVH) simulation analysis, the law of howling noise of gear pair changes with modification parameters is studied. In the small sample training environment, the noise prediction model is constructed based on the priority
weighted Back Propagation (BP) neural network of small noise samples. Taking the minimum noise of high-speed EMU traction gear transmission as the optimization goal, the simulated annealing (SA) algorithm is introduced to solve the model, and the optimal combination of modification parameters
and noise data is obtained. The results show that the prediction accuracy of the prediction model is as high as 98.9%, and it can realize noise prediction under any combination of modification parameters. The optimal modification parameter combination obtained by solving the model through
the SA algorithm is imported into the traction gear transmission system model. The vibration acceleration level obtained by the simulation is 89.647 dB, and the amplitude of the vibration acceleration level is reduced by 25%. It is verified that this modification optimization design can effectively
reduce the gear transmission.
Estrategia de calidad del servicio para mejorar la atención al cliente en heladería
Authors: Otalora Gutiérrez Ana Edith
Published: August 2021

El objetivo de la investigación fue elaborar una estrategia de calidad del servicio para mejorar la atención al cliente en la heladería “El Estudiante”. La metodología fue de tipo descriptiva y propositiva, con un enfoque cuantitativo y cualitativo; los métodos usados fueron; análisis síntesis, inductivo deductivo, histórico lógico y comparativo. Las técnicas e instrumentos usados fueron, observación, entrevista y encuesta. Se obtuvo como resultado, que existen falencias y causales que ocasionan que no se brinde una buena atención al cliente. Se concluye, que con la propuesta se implementaran herramientas de calidad de servicio por lo que fue, desarrollada en base a la confiabilidad, sensibilidad, seguridad, y empatía. Cabe destacar que, esta estrategia debe ser empleada de forma conjunta, es decir, gerencia y personal para conseguir la atención al cliente ideal para la heladería “El Estudiante”.
Mecanismos de resistencia de Escherichia Coli en América Latina
Authors: Peñaloza Piña Lucía Maribel , Aspiazu Hinostroza Karla Alexandra
Published: August 2021

La resistencia bacteriana es un proceso natural de evolución de los microorganismos, y que puede acelerarse por estimulaciones del entorno que obliga a los patógenos a adaptarse para su supervivencia. Se ha convertido en un gran problema a escala mundial, debido a que un número considerable de bacterias de importancia medica han adquirido resistencia a los antibióticos y entre este grupo destaca, Escherichia coli, declarada por la OMS como un patógeno de control por ser causante de enfermedades intrahospitalarias y comunitarias y su alta multirresistencia. Objetivo. Determinar cuáles son los principales mecanismos de resistencia expresados por E. coli en América Latina. Método. Se realizó una revisión sistemática de la evidencia científica con los artículos publicados desde enero del 2000 al 2020. La búsqueda de información se recolectó de las bases de datos PubMed, Scopus, Scielo, Science Direct. Resultados. Se identificaron 430 elementos relevantes para su análisis, posterior a este se incluyeron un total de 18 artículos relevantes para la revisión. Conclusión. El mecanismo de resistencia de Escherichia coli reportado a los betalactámicos es la producción de BLEE entre las que destaca las de tipo CTX-M. De entre los genes resistentes a quinolonas destaca el gen aac (6?) Ib-cr de localización plasmídica, estos, distribuidos de manera general en América Latina.
O desafio da energia solar na Constituição da República Federativa do Brasil de 1988: Do setor público, pelo setor privado, para a Revolução Verde no Brasil.
Authors:   , Alcântara Marcelo Riceputi
Published: August 2021

Presente estudo trabalhou com a hipótese de que os instrumentos públicos responsáveis pelo patamar paradigmático do caso alemão na energia solar podem ser úteis para prover a estabilização e a garantia de continuidade de investimentos necessários à transição energética brasileira, bem como em fornecer parâmetros para uma transformação estrutural das condições do investimento publicamente orientado através da Agência Nacional de Energia Elétrica e da Agência Nacional do Petróleo, de forma a melhor contemplar a complexa rede de investimentos que se impõe como condicionante à ascensão da energia solar. Trabalhou, portanto, com a energia solar como fonte renovável central na transição energética brasileira para um mix energético ambientalmente neutro, tecendo um panorama contemporâneo geral do mercado da energia solar na Europa e no Brasil e reunindo as particularidades que envolvem a complexa rede de investimentos que se impõe a uma transição energética que tenha por elemento central a energia solar. Como arcabouço teórico, utilizou-se das reflexões de Karl Polanyi no intuito de tecer interpretação sistemática da Constituição Econômica contida na Constituição da República Federativa do Brasil de 1988, bem como das lições de Mariana Mazzucato – e seu suporte teórico em Joseph Alois Schumpeter – para elucidar o papel do Estado na transição energética nacional.
Hortas no ensino de biologia: possibilidades, limitações e sugestões
Authors:   , Rodrigues Rafaela Xavier
Published: August 2021

O uso de hortas escolares como ferramenta pedagógica de ensino, além de abordar temas relacionados a educação ambiental e a educação para a saúde, apresentam-se como um laboratório vivo de experiências que permitem associar teoria e prática. Neste sentido, o objetivo geral deste trabalho foi realizar uma revisão integrativa sobre as possibilidades e limitações do uso de hortas no ensino de biologia e elaborar sugestões de metodologias ligadas a práticas com hortas escolares para estudantes do ensino médio. Foram analisados estudos publicados originalmente na língua portuguesa, entre os anos de 2010 a 2019, tendo como referência as bases de dados Portal de Periódicos da CAPES e Google Acadêmico. Fizeram parte do escopo desta revisão 32 estudos que preencheram os critérios de seleção. Utilizamos neste estudo uma abordagem qualitativa com objetivo exploratório e descritivo com procedimentos técnicos de pesquisa bibliográfica. Os estudos permitiram concluir que as hortas escolares podem ser utilizadas como ferramentas de ensino de Biologia e além de favorecerem a interdisciplinaridade, também permitem o estudo de temas transversais relacionados a Educação Ambiental, bem como, ampliam a atuação do professor para além da sala de aula.
Brazilian version of the Functional Gait Assessment: translation, reliability, and validity for use on stroke patients
Authors: Fonseca Paulo , Da Silva Kelven Antonio , Donato do Vale Vanessa , Santos Oliveira Claudia , Dos Santos Alves Vera Lúcia
Published: August 2021

Objective. Translate and adapt the Functional Gait Assessment (FGA) to Brazilian Portuguese as a measure of balance during gait in stroke patients and determine its validity and reliability based on evidence of its measurement properties. Method. A convenience sample of 45 stroke survivors (average of seven months since diagnosis) was included (mean age: 55 years; 51% women). The instrument under consideration was translated and back-translated. The performance of the FGA was assessed by two raters to determine intrarater and interrater reliability. Concurrent and discriminant validity were investigated using the Berg Balance Scale (BBS) as well as normal and fast walking speed. Results. No difficulties with the translation were found during the application of the tests. Therefore, no structural or conceptual changes to the translated version were needed to achieve cultural equivalence. Intrarater (intraclass correlation coefficient=0.93) and interrater reliability (intraclass correlation coefficient=0.90) were almost perfect for the total scores. The reliability of single items was also strong, ranging from 0.74 to 0.95. Concurrent validity with other measures of gait and balance was moderate to substantial. The FGA was correlated (p<0.001) with the BBS (0.71), normal walking speed (0.66), and fast walking speed (0.70). Conclusion. The Brazilian version of the FGA is a reliable, valid instrument for assessing functional gait performance in stroke survivors.
Possible risk of fetal development of autism in pregnant women infected by SARS-CoV-2
Authors: Oliveira Sayd Douglas Rolim Carneiro , Honório Júnior José Eduardo Ribeiro , Aragao Gislei
Published: August 2021

Introduction. In March 2020, the World Health Organization (WHO) announced the emergence of a global pandemic, COVID-19. A disease triggered by the new coronavirus infection (SARS-CoV-2).  More recent findings indicate that the gestational period makes the mother and her offspring more susceptible to the new coronavirus and the rapid progression to the critical stage of the disease. The maternal organism presents a certain degree of immunological and cardiorespiratory deficiency due to physiological adaptations to the gestational period and, consequently, if affected by prenatal infections caused by viruses, they lead to an exacerbated Maternal Immune Activation (MIA), thus contributing to alterations in maternal-fetal neurogenesis, fetal myelinization, and is directly involved in the pathogenesis of neurodevelopmental disorders in the offspring, especially autism. Objective. This study hypothesizes that maternal COVID-19 infections during pregnancy are a potential risk for the offspring to develop Autism Spectrum Disorder. Conclusion. The exposure to viral infectious agents during the gestational period leads to exacerbated maternal immune activation. It contributes to alterations in maternal-fetal neurogenesis and is directly involved in the pathogenesis of neurodevelopmental disorders, being correlated to the predisposition to affective and psychiatric disorders in the offspring. Therefore, greater attention should be given to the offspring of pregnant women infected by COVID-19, since prenatal infectious processes have a strong correlation with the prevalence of Autistic Spectrum Disorder in the offspring.
Influence of Sampling Location on Physical and Mechanical Properties of Full Grain Leather
Authors: Tomljenović Antoneta , Živičnjak Juro , Barišić Andrijana , Akalović Jadranka
Published: August 2021

Full grain leather refers to the strongest and most durable part of the cattle hide, consisting of the grain layer and the part of the underlying corium, and has not been sanded or buffed to remove any imperfections, that means it displays the more natural characteristics of leather. Leather quality changes with sampling location, depending on variation present in the leather fibrous structure. Leather properties were also affected by tanning and finishing processes utilized during production. Full grain leather, instead finishing, sometimes go only through an ironing process for the desired sheen is obtained. Therefore, with the purpose of analysing the influence of the leather processing level, and sampling location on their quality, in this paper, the physical and mechanical properties of differently (synthetic and chromium) tanned finished and non-finished cattle full grain leathers, sampled from the bend, shoulder and belly of side leather cuts were evaluated. Their applicability for footwear uppers were assessed by measuring leather thickness, mass per unit area, apparent density, tensile strength and percentage elongation at break, all according to the standardised test methods.
Udarna izolacĳa kao kriterĳ dizajna obuće
Authors: Mĳović Budimir , Brać Petra , Jelić Josip
Published: August 2021

Sportska obuća pored estetskih mora zadovoljiti i niz funkcionalnih zahtjeva (komfor, vibro-udarna izolacija, termičko-difuzijska zaštita). Konstrukcija pojedinih tipova sportske obuće mora izdržati intenzivna dinamička opterećenja, pa se stoga u konstruiranju sportske obuće daje prioritet zadovoljenju kriterija udarne i vibracijske izolacije. Nove tehnike injekcijskog prešanja donjišta omogućile su realizaciju niza novih konstruktivnih rješenja donjišta.
SOLANUM EMULANS RAF. AND SOLANUM SCABRUM MILL. (SOLANACEAE) IN THE UDMURT REPUBLIC
Authors: Puzyrev A.N.
Published: August 2021

Information about the finds in the Udmurt Republic of two adventive Solanum species is reported. Of these, Solanum emulans is a new species for the flora of Russia. It is brought to the city of Izhevsk with North American grain. In 1993, three of its locations were discovered: at the Izhevsk railway station and in the wastelands in the courtyards of the Izhevsk bakery plant and the Izhevsk bread-receiving enterprise no. 2. Solanum scabrum is occasionally cultivated by amateur gardeners as an exotic plant. In a wild state, it has been known since 2000. To date, eleven of its locations are known in the cities of Izhevsk, Votkinsk, Mozhga, Sarapul, as well as in Zavyalovsky, Uvinsky, Yakshur-Bodinsky and Yarsky districts. Most of its finds are associated with dumps and municipal waste dumping sites. In the conditions of the Udmurt Republic, Solanum emulans and Solanum scabrum are ephemerophytes. The features that distinguish Solanum emulans and Solanum scabrum from morphologically similar species such as Solanum americanum, Solanum nigrum., Solanum retroflexum are given.
CHUVASH DRAMA ABOUT THE GREAT PATRIOTIC WAR
Authors: Kirillova I.Yu.
Published: August 2021

This article is devoted to the analysis of Chuvash plays dedicated to the Great Patriotic War; reveals the peculiarities of their poetics and problems, shows conflict situations that reveal heroic characters. The main attention is paid to the analysis of the plays by N. Aizman, N. Terentyev, M. Yuhma, A. Vasiliev, M. Belov, N. Sidorov, and others. They are united by the themes of courage, heroism, the feat of Soviet people on the battlefield and in the rear. Whereas in the early decades dramatists focused their attention directly on combat events, modern war plays are filled with deep moral content, their plots are distinguished by the sharpness of moral choices, revealing the moral and ethical aspects of the individual.
REVIEW OF THE BOOK: ILYIN A.N. EDUCATION AFFECTED BY REFORMS. MOSCOW: PUBLISHING HOUSE UNIVERSITY BOOK, 2020. 392 p.
Authors: Aksyutina Z.A.
Published: August 2021

The monograph is devoted to a critical understanding of the results of the reform of national education carried out by the liberalized government. First, an excursion is made to the initial stages of education reforms. An attempt is made to describe the existing appearance and essential characteristics of the modern education model. The reform is based on the idea of forming a qualified consumer, which leads to negative phenomena in education. The features of the commercialization of education at the level of school education and higher education are described. Criticism of consumer values in everyday educational practices, leading to the destruction of value educational guidelines, is given. The factors are given, the consequences of which are the moral and intellectual impoverishment of the country. Measures are proposed to improve educational reforms.
CLUSTER POLICY AS A TOOL FOR THE DEVELOPMENT OF THE ECONOMY OF THE RUSSIAN REGIONS
Authors: Radygina S.V.
Published: August 2021

The article researches theoretical aspects of formation and development of territorial clusters: their structure, approaches to definition, typology, key advantages. The regulatory framework for the implementation of cluster policy in the Russian Federation has been defined, as well as an analysis of the level of development achieved on the example of the Udmurt Republic. The main directions of cluster development at the federal level are considered: formation of innovation-territorial and industrial clusters. In each area, public support programmes and mechanisms have been investigated to ensure flexible funding for cluster policies. Favorable opportunities have been identified for the development of cluster projects, including when using the potentials of special economic zones, science and measures to support federal and regional development institutions. The directions of cluster initiatives in the Udmurt Republic have been formulated, the already existing cluster formations, such as innovative-territorial, industrial and tourist-recreational clusters, have been evaluated. The activity of the Russian Association of Clusters and Technology Parks as a subject uniting the organizations of technological and industrial infrastructure has been analyzed. Patterns and priorities of cluster policy development at the present stage are highlighted. Cluster associations are a unique economic system, including a set of industrial enterprises, scientific and educational organizations, and are considered as an effective tool to increase the investment attractiveness of the country and individual regions.
ILLEGAL USE OF MEDICAL ROBOTS: CRIMINAL LAW ASSESSMENT AND CRIMINOLOGICAL RISKS
Authors: Shutova A.A.
Published: August 2021

In the article, the author, on the positive side, assessing the capabilities of robotic medicine, states that today there is no comprehensive study of the safety of medical robots. In this regard, the possibility of risks and threats in the conduct of robotic surgical care cannot be denied. These actions can lead to serious legal consequences for the surgeon, medical institution and manufacturer of the medical robot. The author draws attention to the fact that there is no definition of the concept of "medical robot" in domestic regulatory legal acts. However, the Federal Law of November 21, 2011 No. 323-FZ "On the basics of protecting the health of citizens in the Russian Federation" establishes the concept of "medical product," which is quite capacious and may include the concept of "medical robot."It is necessary to distinguish the concept of "medical robot" as one of the types of medical devices, indicating it in the text of the order of the Ministry of Health of the Russian Federation. The author concludes that it should be understood as a "medical robot," and also attempts to classify the criminological risks arising from its use, depending on the contact of the medical robot with humans. In addition, the publication raises issues of qualifying the actions of attackers who, in the process of illegal access, illegally receive patient data, which forms part of the crime under Art. 137 of the Criminal Code.
Rekomendasi Paket Menu Angkringan Waru Tanjung Bias Dengan Algoritma Frequent Pattern Growth Berbasis Web
Authors: Fajar Lalu Aldila Maulana , Rismayati Ria
Published: August 2021

Culinary business using carts selling various kinds of heavy food, light and drinks, is favored by many people to just fill their stomachs, gather with friends and even family. Culinary businesses or culinary destinations like this are known as Angkringan which are increasingly mushrooming in the millennial generation. Angkringan Waru, located in Tanjung Bias, is a gathering destination for all people to enjoy a relaxed atmosphere on the beach. Angkringan Waru provides 85 types of menus for its customers, the many menus often confuse customers in choosing snacks while enjoying the beachside atmosphere. Starting from these problems, data mining techniques are used with the Frequent Pattern Growth (Fp-Growth) algorithm to recommend items in producing a menu package consisting of 1 snack item and 1 drink item. The dataset used is transaction data from Angkringan Waru as many as 870 transactions, the resulting output is a menu package recommendation rule and implemented in a web for Angkringan Waru. The Fp-Growth Data Mining Application by providing a minimum support value of 20% and Confident 50% with a lift ratio > 1 produces 57 rules or menu package recommendations that will be offered to Angkringan Waru customers. The results of the application in the form of 57 menu package recommendations are then used as recommendations for Angkringan Waru customers, where these menus are the favorite menus of customers at Angkringan Waru.
Analisis Metode K-Nearest Neighbors (K-NN) Dan Naive Bayes Dalam Memprediksi Kelulusan Mahasiswa
Authors: Kartarina Kartarina , Sriwinarti Ni Ketut , Juniarti Ni luh Putu
Published: August 2021

In this research the author aims to apply the K-NN and Naive Bayes algorithms for predicting student graduation rates at Sekolah Tinggi Pariwisata (STP) Mataram, The comparison of these two methods was carried out because based on several previous studies it was found that K-NN and Naive Bayes are well-known classification methods with a good level of accuracy. But which one has a better accuracy rate than the two algorithms, that's what researchers are trying to do. The output of this application is in the form of information on the prediction of student graduation, whether to graduate on time or not on time. The selection of STP as the research location was carried out because of the imbalance between the entry and exit of students who had completed their studies. Students who enter have a large number, but students who graduate on time according to the provisions are far very small, resulting in accumulation of the high number of students in each period of graduation, so it takes the initial predictions to quickly overcome these problems. Based on the results of designing, implementing, testing, and testing the Student Graduation Prediction Application program using the K-NN and Naive Bayes Methods with the Cross Validation method, the result is an accuracy for the K-NN method of 96.18% and for the Naive Bayes method an accuracy of 91.94% with using the RapideMiner accuracy test. So based on the results of the two tests between the K-NN and Naive Bayes methods which produce the highest accuracy, namely the K-NN method with an accuracy of 96.18%. So it can be concluded that the K-NN method is more feasible to use to predict student graduation
Przestrogi dla utopistów. Wizje optimum dóbr w historii idei w książce Andrzeja Waśkiewicza
Authors: Sokół Grzegorz
Published: August 2021

The subject of this essay is Andrzej Waśkiewicz’s book Ludzie – rzeczy – ludzie. O porządkach społecznych, gdzie rzeczy łączą, nie dzielą (People–Things–People: On Social Orders Where Things Connect Rather Than Divide People). The book is the work of a historian of ideas and concerns contemporary searches for alternatives to capitalism: the review presents the book’s overview of visions of society in which the market, property, inequality, or profit do not play significant roles. Such visions reach back to Western utopian social and political thought, from Plato to the nineteenth century. In comparing these ideas with contemporary visions of the world of post-capitalism, the author of the book proposes a general typology of such images. Ultimately, in reference to Simmel, he takes a critical stance toward the proposals, recognizing the exchange of goods to be a fundamental and indispensable element of social life. The author of the review raises two issues that came to mind while reading the book. First, the juxtaposition of texts of a very different nature within the uniform category of “utopia” causes us to question the role and status of reflections regarding the future and of speculative theory in contemporary social thought; second, such a juxtaposition suggests that reflecting on the social “optimal good” requires a much more precise and complex conception of a “thing,” for instance, as is proposed by new materialism or anthropological studies of objects and value as such.
KEHENDAK TUHAN DALAM MANIFESTASI ‘AZAB PERSPEKTIF AL-QUR’AN
Authors: Fadil Marjan , Putra Pristian Hadi
Published: August 2021

Tuhan memiliki kehendak mutlak dalam menghidupkan, mengatur, menjaga, memelihara hingga mematikan umat manusia. Salah satu kehendak Tuhan terbukti dalam bentuk ‘Azab yang bisa menimpa siapapun yang ia kehendaki. Jika Tuhan telah berkehendak, maka tidak ada apapun atau seorangpun yang mampu mencegahnya. Manifestasi kehendak Tuhan ini digambarkan dalam dalil-dalil Al-Qur’an sebagai bentuk kemaha kuasaan-Nya. Oleh sebab itu perlu diketahui bentuk, tujuan serta sasaran ‘Azab yang dimaksud dari Tuhan agar manusia mampu menjalani perintah dan menjauhi larangan-Nya. Kata ‘Azab sendiri terulang di dalam Al-Qur’an 329 kali yang mengacu pada tindakan pengusiran, ketakutan di dalam hati, hukuman dunia serta bencana alam. Penelitian ini menganalisis tindakan dalam kehendak Tuhan yang termanifestasi dalam tema ‘Azab yang terdapat di dalam Al-Qur’an dengan metode tematik.

Kata Kunci: Kehendak Tuhan, ‘Azab, Al-Qur’an
Evaluación de la función neuromuscular
Authors:   Universidad Santiago de Cal, Ordoñez Mora Leidy Tatiana , Sánchez Diana Patricia ,   Universidad Santiago de Cali, Daza Arana Jorge Enrique ,   Universidad Santiago de Cali, Álvarez Toro Lina Johanna ,   Universidad del Atlántico, Penagos Gómez Paola Teresa ,   Universidad Escuela Colombiana de Rehabilitación, Valencia Buitrago Marysol ,   Universidad Autónoma de Manizales, Giraldo Jiménez Claudia Fernanda ,   Universidad Santiago de Cali, Pinzón Bernal Mónica Yamile ,   Universidad Autónoma de Manizales, Naranjo Aristizábal María Mercedes ,   Universidad Autónoma de Manizales, Jaramillo Losada Jennifer ,   Universidad Santiago de Cali, Carabalí Cachimbo Sandra Milena ,   Universidad Santiago de Cali
Published: August 2021

Este libro pretende abordar la importancia de realizar procesos evaluativos, que permitan una correlación y análisis clínico considerando la perspectiva del movimiento corporal humano, a partir del examen y la evaluación. Por tanto, una adecuada valoración de la función neuromuscular garantiza la adecuada interacción como elemento inicial planificador y efector del movimiento a diferentes niveles, permitiendo un adecuado diseño y ejecución de programas de rehabilitación neuromuscular, disminución del riesgo de lesiones y el paso a las actividades de la vida diaria y ocupacionales.
Monedas disruptivas: atractivo financiero y tecnológico
Authors:   Institución Universitaria Escuela nacional del deporte, Fernández Hurtado Saúl Rick , Portocarrero Cuero Juan Carlos ,   Universidad Santiago de Cali, Vila Pacheco Alberth ,   Universidad Santiago de Cali, Garcés Isaza Juan Camilo ,   Universidad Santiago de Cali, Arboleda Riaño Karen Lizeth ,   STF GROUP S.A, Martínez Martínez Luz Ángela ,   Universidad Autónoma de Occidente, Arias Ruiz Julián Alberto ,   Universidad Santiago de Cali, Arcos Salazar Juan Sebastián ,   Universidad Santiago de Cali, Valencia Robles Federiko ,   Universidad Santiago de Cali, Hernández Holguín Hammer Harvey Sebastián ,   BIG HAMMER, Barahona Viáfara Simón Stiven ,   Universidad Santiago de Cali, Correa Bolaños Jeniffer ,   Universidad Santiago de Cali, Silva Gaviria Katherin Andrea ,   Universidad Santiago de Cali, Zuluaga Alzate Daniel Alejandro ,   Universidad Santiago de Cali, Ruiz Cortés Lady Giovanna ,   Universidad Santiago de Cali, Osorio Agudelo Yesid F. ,   Universidad Santiago de Cali, Castro Cardona Luzby Deyeni ,   Universidad Santiago de Cali, Velasco Pinillos Juan David ,   Universidad Santiago de Cali, Montaño Bonilla Wanda ,   Universidad Santiago de Cali, Riascos Ana Seidy ,   Universidad Santiago de Cali, Cabrera García María Juliana ,   Universidad Santiago de Cali
Published: August 2021

El Centro de Estudios e Investigaciones en Desarrollo Regional (CEIDER) de la Facultad de Ciencias Económicas y Empresariales de la Universidad Santiago de Cali, coordina sus actividades de investigación en la línea de Ciencia, Tecnología e Innovación con responsabilidad social; su eje-centro de actividades se enmarca en el desarrollo regional, medio ambiente y sociedad, para el impulso de sus líneas de investigación en temas de sostenibilidad ambiental, gestión organizacional, responsabilidad social empresarial, contabilidad internacional, teoría y pedagogía contable, comercio internacional y competitividad. La siguiente compilación hace parte de un trabajo de investigación y colaboración de pares, que busca contribuir desde la academia para enriquecer la temática de las monedas disruptivas.
COMPARISON OF THE EFFECT OF PHENYLEPHRINE AND EPHEDRINE ON UMBILICALARTERIAL BLOOD GAS PARAMETERS IN ELECTIVE CAESAREAN SECTION UNDER LUMBAR SUBARACHNOID BLOCK
Authors: Madhu Athira S , Thomas Rosely , Thomas Koshy
Published: August 2021

Introduction: Potential side effects such as supraventricular tachycardia, tachyphylaxis, and most importantly, fetal acidosis render the use of
ephedrine as a rst line agent to treat hypotension in obstetric patient debatable. Phenylephrine, an alternative drug, has a reduced incidence of
nausea and vomiting as well as decreased fetal acidosis, which gives it an advantage over the use of ephedrine.
Materials and methods: We conducted an observational study in 68 ASA II patients scheduled for lower segment caesarean section. Parturients
who satised the inclusion criteria were randomly assigned into one of the two groups of 34 each- group P with parturients who were to receive
phenylephrine boluses in 100 mcg increments and group E with parturients who were to receive ephedrine boluses in 6mg increments when they
developed hypotension. Fetal umbilical arterial blood gas was analyzed and parameters were compared.
Results: On analyzing umbilical arterial blood values, a lower mean pH was found in group E (7.27± 0.09) when compared to group P (7.3± 0.04).
Also a higher PCO value (49± 7.4) was found in group E when compared to group P (43.9 ± 6.4). Other umbilical arterial blood gas values were 2
comparable between both groups