Self-expanding Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients
Authors: Van Mieghem Nicolas M. , Deeb G. Michael , Søndergaard Lars , Grube Eberhard , Windecker Stephan , Gada Hemal , Mumtaz Mubashir , Olsen Peter S. , Heiser John C. , Merhi William , Kleiman Neal S. , Chetcuti Stanley J. , Gleason Thomas G. , Lee Joon Sup , Cheng Wen , Makkar Raj R. , Crestanello Juan , George Barry , George Isaac , Kodali Susheel , Yakubov Steven J. , Serruys Patrick W. , Lange Rüdiger , Piazza Nicolo , Williams Mathew R. , Oh Jae K. , Adams David H. , Li Shuzhen , Reardon Michael J. ,   SURTAVI Trial Investigators, Gitter Christopher , Meyer Karen , Roberts Dana , Bae Richard , Sorajja Paul , Sun Benjamin , Askew Judah , Eales Frazier , Flavin Thomas , Goessl Mario , Kshettry Vibhu , Mooney Michael , Pedersen Wesley , Poulose Anil , Roohani Pezhman , Saeid Farivar Robert , Shronts Richard , Tarrel Ronald , Young Mark , Butkus Eddy , Pendleton Kristin , Fry Robert , Heine Carl , La Roe Kristin , Tran Tin , Weig Laura , Agarwal Himanshu , Langdon Thomas , Satpathy Ruby , Batter John , Bremer Karen , Indukuri Unajyothi , Baas Marijke , Oomes-Sistermans Corry , Smits Manola , Coenen Carien , Driesen Inge , Lauryssen Lia , Poorter Margreet , Schaap Jeroen , Bentala Mohamed , den Heijer Peter , Pieter Jan , Remmers Michel , Story Marie , van Erven Paul M.M. , Verbiest Henk , Vos Jeroen , Bennett Michelle , Dunaj Wendy , Seaton Deborah , Waller Deborah , Khandheria Bijoy , Bajwa Tanvir , O'Hair Daniel , Ahmed Arshad , Allaqaband Suhail , Gheith Ayman , Marriott Elizabeth , Qhavi Ajaz , Saxena Varun Kumar , Shhadeh Akram , Werner Paul , Yeomans Christine , Bessette Lynn , Byrne Jessica , Kieckhefer Heather , Munoz Marleny , Russo Elizabeth , Klein Jason , Morgan Michael , Byrne Timothy , Caskey Michael , Amabile Orazio , Brady Kevin , Chung Steven , Dacanay Kelly , Fang H. Kenith , Franz Douglas , Kelly Claire , Loli Akil , Payne Jeremy , Pershad Ashish , Wang Norman , Lott Jessi , Pool-Owens C. Angele , Porter Charlotte , Hennan Jeffrey A. , Garrett H. Edward , Paulus Basil , Craig John , Elijovich Lucas , Samaha Joseph , Wolf Bradley , Wright Lance , Zoghbi Gilbert , Willcott Leslie , Roberts Brad , Hebeler Robert , Stoler Robert , Graybeal Dion , Grayburn Paul , Henry Carl , Mir Osman , Vallabhan Ravi , Fanous Matthew , Kaufman Jenifer , Chang James , Manning Warren , Riley Marilyn , Khabbaz Kamal , Laham Roger , Popma Jeffrey , Burke David , Caplan Louis , Chui Shing Fung , Guibone Kim , Kumar Sandeep , Lioutas Vasileios-Arsenios , Liu David , Nathan Senthil , Pinto Duane , Searls D. Eric , Fisher Susan , Guirgues Lindsay , Henderson Sue , Loving Laura Ashley , McWalters Nicole , Patterson Kelly , Burkart Jesse , Carcedo Bryan , Stacey Russell , Bladergroen Mark , Lim David Scott , Edmonson Supakunya , Epps Stacey , Katz Marc Robert , Ng Ken , Sangha Amandeep , Aucoin Jennifer , Roberts Monique , Aubin Jaime , Hotard Callie , Tassin Michelle , Fail Peter , Feinberg Edgar , Netherland Donald , Abben Richard , Allam Mohamad , Bates Michael , Dearman Richard , Gervais Donald , Haight Edward , Metes Michael , Naquin Jeanette , Tedesco Victor , Thibodeaux Lisa , Thompson Karen , Aberle Sally , Amaro Dana , Grey William , Rose Geoffrey , Scherer Markus , Rinaldi Michael , Skipper Eric , Bridges Charles , Downey William , Iyengar Phaniraj , Martin Jerry , Ryan Liam , Stiegel Robert , Story John S. , Alsabaawi Khaled , Gheorghiu Mitch , Singh Chetana , Yashar Jason , Siegel Robert , Cheng Wen , Makkar Raj , Altman Karen , Jilaihawi Hasan , Kar Saibal , Khouw Stephanie , Mody Cyrus , Ramzy Danny , Salseth Tracey , Stegic Jasminka , Trento Alfredo , Lazarte Rosa , Sohn Jeanie , Hahn Rebecca , Khalique Omar , George Isaac , Kodali Susheel , Williams Mathew , Gonzalez Castellon Marco , Gutierrez Contreras Jose , Kitago Tomoko , Kummer Benjamin , Lekic Tim , Miller Eliza , Naka Yoshifumi , Nazif Tamim , Qureshi Abid , Rostanski Sara , Smith Craig , Willey Joshua , Yaghi Shadi , Abreu Leana , Clement Emerson , Sabir Sajjad , Aji Janah , Bowen Frank , Kaddissi Georges , Mirsen Thomas , Muntazar Muhammad , Ogbara Jeffrey , Rosenbloom Michael , Schell Wendy , Then Ryna , Carl Heidi , Huang Hong , Kreydi Ghassan , Wolak Heather , Sandidge Gregory , Ali Omar , Asfaw Zewditu , Henry Scott , Kafi Ali , Schreiber Theodore , Andaya Lourdes , Baciewicz Frank , Bassett Joseph , Choksi Nishit , Kassas Safwan , Munir Ahmad , Kothmeier Franziska , Stroh Annemarie , Goppel Gertrud , Hettich Ina , Bleiziffer Sabine , Hengstenberg Christian , Opitz Anke , Ruge Hendrik , Badiu Catalin Constantin , Brenner Susanne , Ehlmidi Yacine , Herold Ulf , Kasel Albert , Kreuzpointner Robert Josef , Lange Rüdiger , Mazzitelli Domenico , Poppert Holger , Seifert Christian , Vincze Dóra , Voss Bernhard , Camuglia Krista , Cowhig Dahlia , Newbold Stephanie , Pierce Cynthia , Wootton Samantha , Vemulapalli Sreekanth , Velazquez Eric , Harrison J. Kevin , Hughes G. Chad , Ali Yasmin , Babi Ali , Banks Adam , Gaca Jeffrey , Glower Donald , Gokhale Sankalp , Halim Sharif , Hendry Robert , Hernandez Christian , Kiefer Todd , Klein Michael , Kolls Bradley , Marrotte Eric , Pineda Maldonado Andres , Price Andrew , Sherwood Matthew , Swisher Christa , Van Wyck David , Vavalle John , Vora Amit , Wang Andrew , Zeylikman Yuriy , Amber Kara , Barnitt Anne , Lamm Janet , Mandelstam Lara , Schroeder Ryan , Sumner Roxanne , Nair Deepu , De Ajanta , Gaudiani Vincent , Joye James , Brown Lidia , Hessler Christine , Rammohan Chad , Vial Conrad , Charles Elizabeth , DeQuesada Angela , Kaner Maria , Mathewson Sonya , Pitts Kristy , Wheeler Lauren , Wilson Ashley , Davidson Estella , Frohwein Stephen , Lerakis Stamatios , Merlino John , Sullivan Angela , Babaliaros Vasilis , Guyton Robert , Thourani Vinod , Anderson Aaron , Belagaje Samir , Benameur Karima , Devireddy Chandan , Greene James , Harrison Amy , Hudson Kristen , Leshnower Bradley , Lieppe William , Macheers Steven , Mavromatis Kreton , Miller Jeffrey , Nahab Fadi , Sanders Keith A. , Sarin Eric , Stewart James , Winkel Daniel , Duininck Liesbeth W. , Gussinklo Titia , Jadoenath-Oedai Shashikala , Ruiter Arno , van den Berg Nico , van der Velden-Macauley Liz E.N. , van Huis Maaike , Verelst Silvia G.R. , Geleijnse Marcel Leonard , Vletter Wim B. , Bekker Margaretha , Kappetein A. Pieter , Van Mieghem Nicolas M. , Bekkers Joseph A. , Biesheuvel Karla , Birim Ozcan , Bol Raap Goris , Daemen Joost , de Jaegere Peter Paul , de Lind van Wijngaarden Rob , Khajeh Ladbon , Kik Charles , Koudstaal Peter J. , Oei Frans B.S. , Scheele Maaike , van de Woestijne Pieter , van Geuns Robert-Jan , van Leeuwen Wouter J. , Henderson Amy , Straight Faye , Schneider David , Tischler Marc , Dauerman Harold , Ittleman Frank , Schmoker Joseph , Abernethy Abraham , Alkhalil Imran , Azarbal Amir , Chava Sreedivya , Commichau Christopher , Coyle David , Denkmann Jan , Destephan Christine , Ehle Gregory , El-Haddad Mohamed , Falduto Catherine , Gorman Mark , Kadavath Sabeeda , Leavitt Bruce , Mack Allison , Malasana Gangadhar , Moossavi Shahab , Phuong Newton , Rambod Mehdi , Seecheran Naveen , Sharma Ashwini , Terrien Edward , Worgan Barbara , Zeglin-Sawczuk Magdalena , Burgess Brian , Killbride Susan , Temple Amy , Burnside Joyce , Good Christopher , Agarwal Shikhar , Casale Alfred , Skelding Kimberly , Carter Russell , Cummings Christopher , Grana Vicente , Haegerl Carl , Harjai Kishore , Holland Neil , Singh Deepak , Stahl Russell , Stella Joseph , Stewart Birute , Long Doug , Wood Kim , Alexander Donna , Barton Sally , Logtens Elaine , Marsh Anna-Marie , McAdam John , Kovac Jan , Mariscalco Giovanni , Spyt Tomasz , Garimella Soumitra , Szostek Jacek , Zlocha Viktor , Kirkland Lavonda , Reid Lori , Reilly Susan , Menderhall Melody , Martin William , Park Steven , Seshiah Puvi , Smith J. Michael , Gersch Karen , Hiratzka Loren , Kachoris John , Okum Eric , Cardozo Maria , Cyr Giselle , Duvall W. Lane , Flynn Aidan , Krupowies Nancy , Parker Matthew , Hagberg Robert , McKay Raymond , Azemi Talhat , Brown Robert , Fusco Daniel , Hammond Jonathan , Hosley Catherine , Kiernan Francis , Margey Ronan , Preissler Paul , Sadiq Immad , Silverman Isaac , Taboada Susan , Underhill David , Escobar Jose , Lopez Becky , Mullin Stephanie , Quesada Christine , Lawrence Tracy , Naqvi Tasneem , Matthews Ray V. , Starnes Vaughn , Clavijo Leonardo , Cunningham Mark , Kim-Tenser May , Sanossian Nerses , Shavelle David , DelMotte Danielle , Henry Samantha , Moltrassie JoAnne , Solanki Ashish , Cooper Raymond , Lee James , Parikh Sachin , Wang Dee Dee , Zweig Brian , O'Neill William , Paone Gaetano , Borgi Jamil , Brewer Robert , Eng Marvin , Greenbaum Adam , Guerrero Mayra , Miller Daniel , Mitsias Panayiotis , Morgan Jeffrey , Nemeh Hassan , Alcaide Muñoz Javier , Medina Fernandez Maria , Carrasco Chinchilla Fernando , Rodríguez Bailón Isabel , Hernández García José Maria , Such Miguel , Alonso-Briales Juan , De La Cruz Cosme Carlos , Dominguez-Franco Antonio , Mataró López Maria J. , Melero Jose Maria , Muñoz-Garcia Antonio-Jesus , Sanchez Espin Gemma , Fernández Maese Jose Manuel , Torres Marta , Villa Suarez Esther , De La Hera Jesus M. , Llosa Cortina Juan Carlos , Morís de la Tassa Cesar , Avanzas Fernández Pablo , Benavente Fernández Lorena , Calleja Sergio , Del Valle Raquel , Morales Pérez Carlos , Silva Jacobo , Bluntschli Eva , Keller Dorothee , Maritz Sandra , Ruest Rafael , Schönenberger Christa , Trovato Moreno , Brugger Nicolas , Göber Volkhard , Kurmann Reto , Reineke Sylvia , Zürcher Fabian , Carrel Thierry , Windecker Stephan , Arnold Marcel , Balasubramaniam Rupashani , Bellwald Sebastian , Beyeler Morin , Broeg Anne , Bühlmann Monika , Büllesfeld Lutz , Capek Lukas , Chaloulos-Lakovidis Panagiotis , Corpataux Noe , Englberger Lars , Gloekler Steffen , Goldlin Martina Beatrice , Huber Christoph , Khattab Ahmed , Kurmann Rebekka , Lanz Jonas , Liesirova Kai , Maamari Basel , Mattle Heinrich , Meinel Thomas , Panos Leonidas , Praz Fabien , Schönhoff Florian , Sleszak Agnieszka , Spirito Alessandro , Stortecky Stefan , Vaisnora Lukas , Von Martial Rascha , Wenaweser Peter , Zuk Katarzyna , Musso Iris , Allen Meredith , Gonzales Michael , Horton Ken , Doty John , Whisenant Brian , Caine William , Clayson Stephen , Harkness James , Hoesch Robert , Huan Mengjing Chloe , Jones Kent , Miner Edward , Reid Bruce , Sunderman Elizabeth , Citro Kathleen , Fisher Michele , Willhide Judi , Corretti Mary , Conte John , Mandal Kaushik , Resar Jon , Chacko Matthews , Hasan Rani , Heil Barbara , Marsh Elizabeth , Price Joel , Sciortino Chris , Shah Ashish , Tolentino Jennie , Bui Anh , Lee Ming Sum , Watanabe Colin , Aharonian Vicken , Moore Naing , Pfeffer Thomas , Ajani Zahra , Mansukhani Prakash , Sangha Navdeep , Yun Kwok , Hylander Susanne , Bäck Magnus , Corbascio Matthias , Hillebrant Carl-Gustaf , Rück Andreas , De Palma Rodney , Feldt Kari , Kostulas Konstantinos , Settergren Magnus , Yamasaki Keita , Anderson Michelle , Bloomfield Charlotte E. , Burtonwood Natalie , Harland Charlotte , Somers Kathryn , Ware Tracey L. , Deakin Sarah , Geldard Susan , Schlosshan Dominik , Blackman Daniel , Kaul Pankaj , Evans Betsy , Javangula Kalyana C. , Limaye Sameer S. , Malkin Christopher J. , Wanklyn Peter , Farhi Anita , Manapat Arika , Maranan Leandro , Mihelis Effe , Ng Amelia , Ricketts Melissa , Kronzon Itzhak , Perk Gila , Brinster Derek , Kliger Chad , Azhar Salman , Bonomo Roger , Dharva Rubin , Fontana Gregory , Mandel Steven , Mehla Priti , Patel Nirav , Plestis Konstadinos , Fox Stephanie , Mardell Stephen , Novick Teresa , Sandie Kelsey , de Jonge Wes , McLeod Claudia , Mroz Luke , Weigand Andrea , Chu Michael , Kiaii Bob , Teefy Patrick , Bagur Rodrigo , Debicki Derek , Diamantouros Pantelis , Gofton Teneille , Mandzia Jennifer , McKenzie F. 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Raymond , Groves Elliott , Hanna Nicholas , Kalafut Mary , Levisman Jeffrey , Mellinger Douglas , Odunukan Olufunso , Ong Daniel , Oyama Jared , Panguluri Praveen , Patel Aalok , Raney Aidan , Rao Suraj , Schultz Jason , Sharma Alok , Stinis Curtiss , Thompson Caleb , Wadia Subeer , Walsh Joseph , White Jeremy , Purrington Elizabeth , Zulick Chelle , Murillo Jaime , Mahoney Paul , Newton Joseph , Rich Jeffrey , Bagameri Gabor , Cohen Daniel , Dimeling George , Jordan Grace , Mistry Neville , Philpott Jonathan , Sirak John , Sourbeer Sarah , Talreja Deepak , Zweifler Richard , Helm Elizabeth , Postema Karen , Van Over Elizabeth , Chilton Dale , Mitchell Lou , Heiser John , Merhi William , Berkompas Duane , Fanning Justin , Khan Muhib , Leung Wai Sang Stephane , Omran Kaskar , Patzelt Lawrence , Rai Vivek , Thoits Timothy , Vijayappa Madhu , Kasle Margie , Trautman Leigh , Dash Rajiv , Liang David , Fischbein Michael , Miller Craig , Yeung Alan , Fearon William , George Paul , Speight Martina , Tai Waimai Amy , Albersen Inke , Bras Rebecca Gornelda , Feirabend Conny , Helwig-Vernooij Johanna Catharina , Kranen Gerda , Oostveen Manfred , Rost Ilona , van Deutekom Inge , van Weelden Atie , Heijmen Robin , ten Berg Jurriën , Bosschaert Mike Arnoud Ramon , de Kroon Thomas L. , Hilkens Pieter H.E. , Mast Eliza G. , Rensing Bernard , Schonewille W.J. , van den Akker Alberta Nelina , Haag Elizabeth , Jennings Joan , Krug Patricia , Santiago Lyn , Seth Sonika , Dimsuyu Nellia , Mihalatos Dennis , Petrossian George , Robinson Newell , Bercow Neil , Berke Andrew , Deutsch Ezra , Stevens Perry , Brown Sue , Dos Santos Jardim Victor , Radford Nicole , Sookhoo Venessa , Kyereme Kojo , Punzalan Rachel , Reynolds Rebecca , Sculeany Bogdan , Sharma Rakesh , Stuart Amanda , Brecker Stephen , Jahangiri Marjan , Alassa Aiman , Chandrasekaran Venkatachalam , Clarke Brian , Dowling Cameron , Moynihan Barry , Roy D. , Sarsam Mazin , Bess Renee , Henkel Megan , Herbert Natalie , Cohen Gerald , Batra Sanjay , Davis Thomas , Aboukasm Amer , Cullis Paul , LaLonde Thomas , Martin James , Yamasaki Hiroshi , Burkert Marylynn , Kingma Barbara , Wheatley Jessica , Segar Douglas , Heimansohn David , Hermiller James , Ball Michael , Elsner Gregory , Hanan Scott , Moainie Sina , Nukes Theodore , Reibold Patrick , Robison Robert , Salerno Christopher , Sampson Andrew , Walts Peter , Wandel Emily , Li Mary , Sarker Sulagna , Ahmed Shaheeda , Fremes Stephen , Radhakrishnan Sam , Arbel Yaron , Christakis George , Cohen Gideon , Czarnecki Andrew , Elbaz-Greener Gabby , Feld Yair , Hopyan Julia , Komatsu Ikki , McCraig Kathleen , Shuvy Menashe , Toma Jonathan , Vincenzo Basile , Wheeler Cindi , Wijeysundera Harindra , Wolff Rafael , Beck Pamela , Cabral Donna , DaCosta Christine , Hudson Laura , Pastie Michelle , Abrahams Nicole , Altamar Ingrid , Buitrago Mike , Cassman Gabrielle , Leibovici Zvi , Nelson Ana , Recchia Kelly , Robbins Gillian , Studor Kelly , Bethea Brian , Beyer Erik , Evans Sharron , Goodis Caleene , Malek Ali , Mueller-Kronast Nils , Pan Hao , Pantoja Claudia , Ramos Angelica , Wells Channing , Youngblood Colten , Snelus Patricia , Gopal Deepika , Jackson Kristie , Brown David , Ryan William , Brinkman William , Gopal Ambarish , Harrington Katherine , Mack Michael , Nosnik Pedro , Potluri Srinivasa , Smith Robert , Szerlip Molly , Blaylock Candice , Brinegar Patricia , Canter Laura , Green LaShawna , Green Lisa , Hazen Pamela , Jacobs Amber , Khan Saba , Ludwig Sheryl , Mata Mary , Moore Tammara , Underwood Carol , Faza Nadeen , Little Stephen , Nagueh Sherif , Kleiman Neal , Reardon Michael , Albright Kimberly , Atkins Marvin , Barker Colin , Bledsoe Donald , Chiu David , Goel Sachin , Gray Tiffany , Imperial-Aubin Delmar , Lin Chun , Moye Stacy , Ramchandani Mahesh , Ramlawi Basel , Reul Ross , Reyes Manuel , Scheinin Scott , Volpi John , White Shannon , Wyler von Ballmoos Moritz , Blackburn Beth , Wong Richmond , Hart Chari , Whitacker Pearl , Lau Jeffrey , Spies Christian , Badawi Ramy , Graner Sarah , Nakamura Dean , Plank Benjamin , Salem Rony , Seto Todd , Valenta Douglas , Cruz Amber , Gallagher Lauren , Schuck Laura , Siki Mary , Weeks Andre , Fishman Lise , Schwarz Teresa , Bavaria Joseph , Herrmann Howard , Anwaruddin Saif , Desai Nimesh , Giri Jay , Khella Sami , Li Robert , McGarvery Michael , Messe Steven , Price Raymond , Quinn Colin , Szeto Wilson , Vallabhajosyula Prashanth , Sun Yang , Wu Libo , Tsang Wendy , Thavendiranathan Dinesh , Feindel Chris , Horlick Eric , Casaubon Leanne , Cusimano Robert , Del Campo Martin , Osten Mark , Silver Frank , Höwisch-Pengel Rita , Lechner Gabriele , Steiger Barbara , Allgeier Martin M. , Jander Nikolaus , Beyersdorf Friedhelm , Neumann Franz-Josef , Büttner Heinz Joachim , Comberg Thomas , Diab Nawras , Gick Michael , Günkel Ludwig , Pingpoh Clarence , Rothe H. Jürgen , Siepe Matthias , Thoma Martin , Winker Thomas , Hager Christine , Sänger Ulrike , Stader Michael , Biaggi Patric , Gruner Christiane , Stämpfli Simon , Binder Ronald , Corti Roberto , Falk Volkmar , Holy Erik Walter , Maisano Francesco , Grünenfelder Jürg , Holubec Tomas , Maier Willibald , Nietlispach Fabian , Wegener Susanne , Atkinson Rachel , Davis Angela , Hall Suzanne , Mangene Samantha , Mazzurco Stacey , Hoit Brian , Musarra Raymond , Costa Marco , Markowitz Alan , Asi Khaled , Attizzani Guilherme , Chuang Dennis , Elgudin Yakov , Garcia Carlos , Jadhav Vikram , Le Scott , Miller Benjamin , Serkin Zakhar , Shams Tanzila , Sila Cathy , Simon Daniel , Bezerra Hiram , Deo Salil , Anderson Jennifer , Greening Kyle , Karson Jodi , Page Susie , Shawgo Tilitha , Freeman Jon , Mulhern Kevin , Nath Jayant , Tadros Peter , Zorn George , Hockstad Eric , Lechtenberg Colleen , Muehlebach Gregory , Rippee Michael , Rosterman Lee , Sundararajan Jayashree , Wang Yunxia , Wiley Mark , Atapattu Suresh , Marin y Kall Christian , Lowery Maureen , de Marchena Eduardo , Salerno Tomas , Alfonso Carlos , Carillo Roger , Ferreira Alexandre , Panos Anthony , Romano Jose , Williams Donald , Bhatt Shradha , Migda Erin , Oakley Jessica , Warshal Wendy , Wilcock Sandra , Booher Anna , LaBounty Troy , Chetcuti Stanley , Deeb G. Michael , Adelman Eric , Boyle Mary Jo , Geml Rachel , Grossman P. Michael , Guerin Danielle , Hodges Kelley , Kim Karen , Lammers Deborah , McDermott Margaret , Menees Daniel , Pace Robert , Patel Himanshu , Prager Richard , Ramchandren Sindhu , Romano Matthew , Stamper Angela , Wang Michael , Zahuranec Darin , Ziarkiewicz Melanie , Charlebois Cheryl , Chilton Colleen , Labinaz Marino , Ruel Marc , Glover Chris , Lam Khanh , Masters Roy , Steffenhagen Nikolai , Enlow-Germovsek Melissa , Konopka Kristin , McGargle Rachel , Travis Melissa , Anderson Kathy , Cavalcante Joao , Crock Fred , Edelman Kathy , Katz William , Gleason Thomas , Lee Joon Sup , Sultan Ibrahim , Aghaebrahim Amin Nima , Al-Bayai Alhamza , Bonaccorsi Christina , Campbell David , Giurgiutiu Dan-Victor , Gulati Deepak , Hawkes Christine , Henry Lisa , Jadhav Ashutosh , Kenmuir Cynthia , Klein Bradley , Kliner Dustin , Limaye Kaustubh , Nanduri Sunanda , Navid Forozan , Patel Pratit , Rangaraju Srikant , Rocha Marcelo , Schindler John , Shoirah Hazem , Streib Christopher , Tadi Prasanna , Tememe Danoushka , Totoraitis Ruta , Walker Greg , Ziayee Habibullah , Caufield Lori , Yeager Carol , Forbes Jennifer , Schwart Karl Q. , Knight Peter , Ling Frederick , Benesch Curtis , Bogachan Sahin , Hicks George , Kelly Adam , Narins Craig , Stuver Thomas , Adams Kathy , Blair-Anton Lynn , Haynes Mary Lou , Watts Carol , Baker Michael , Mendes Lisa , Ball Stephen , Goel Kashish , Kaiser Clayton , Robbins Mark , Zhao David , Ahmad Rashid , Crenshaw Marshall , Fredi Joseph , Hermann Lisa , Hoff Steven , Kirshner Howard , Levack Melissa , Mittal Shilpi , O'Duffy Anne , Petracek Michael , Baer Judy , Liang Grace , Nguyen Son , Heidenreich Paul , Nguyen Patricia , Burdon Thomas , Giacomini John , Yong Celina , Buchbinder Maurice , Fann James , Kilgore Shannon , Mitchell R. Scott , McDaniel Sharon , Pack Angelina , White Wendi , Young Travis , Burgess Pam , Pu Min , Upadhya Bharathi , Applegate Robert , Kon Neal , Arnan Martinson , Baghshomali Sanam , Bishop Laura , Bradbury Edward , Gandhi Sanjay , Kincaid Edward , Lefkowitz David , Lisle Benjamin , Batteria Melissa , Rerisi Elizabeth , Stepinowski Kimberly , Senicola Tanya , Goncalves John , Schubach Scott , Schwartz Richard , Antaky Karin , Christiansen Colleen , Marzo Kevin , Michel Kathleen , Misra Ajay , Varghese Princy , Wirkowski Elizieta , Levesque Linda , Sugeng Lissa , Cleman Michael , Forrest John K. , Hashim Sabet , Mangi Abeel , Amin Hardick , Darr Umer , Dewar Michael , Faheem Osman , Geirsson Arnar , Greer David M. , Kaleel Abdel , Kaple Ryan , Lansky Alexandra , MacGrory Brian , Pfau Steven , Schindler Joseph , Thompson Craig , Youn Teddy , Yuh David , Yun James 
Published: August 2022

Importance

In patients with severe aortic valve stenosis at intermediate surgical risk, transcatheter aortic valve replacement (TAVR) with a self-expanding supra-annular valve was noninferior to surgery for all-cause mortality or disabling stroke at 2 years. Comparisons of longer-term clinical and hemodynamic outcomes in these patients are limited.

Objective

To report prespecified secondary 5-year outcomes from the Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (SURTAVI) randomized clinical trial.

Design, Setting, and Participants

SURTAVI is a prospective randomized, unblinded clinical trial. Randomization was stratified by investigational site and need for revascularization determined by the local heart teams. Patients with severe aortic valve stenosis deemed to be at intermediate risk of 30-day surgical mortality were enrolled at 87 centers from June 19, 2012, to June 30, 2016, in Europe and North America. Analysis took place between August and October 2021.

Intervention

Patients were randomized to TAVR with a self-expanding, supra-annular transcatheter or a surgical bioprosthesis.

Main Outcomes and Measures

The prespecified secondary end points of death or disabling stroke and other adverse events and hemodynamic findings at 5 years. An independent clinical event committee adjudicated all serious adverse events and an independent echocardiographic core laboratory evaluated all echocardiograms at 5 years.

Results

A total of 1660 individuals underwent an attempted TAVR (n = 864) or surgical (n = 796) procedure. The mean (SD) age was 79.8 (6.2) years, 724 (43.6%) were female, and the mean (SD) Society of Thoracic Surgery Predicted Risk of Mortality score was 4.5% (1.6%). At 5 years, the rates of death or disabling stroke were similar (TAVR, 31.3% vs surgery, 30.8%; hazard ratio, 1.02 [95% CI, 0.85-1.22]; P = .85). Transprosthetic gradients remained lower (mean [SD], 8.6 [5.5] mm Hg vs 11.2 [6.0] mm Hg; P &amp;lt; .001) and aortic valve areas were higher (mean [SD], 2.2 [0.7] cm2 vs 1.8 [0.6] cm2; P &amp;lt; .001) with TAVR vs surgery. More patients had moderate/severe paravalvular leak with TAVR than surgery (11 [3.0%] vs 2 [0.7%]; risk difference, 2.37% [95% CI, 0.17%- 4.85%]; P = .05). New pacemaker implantation rates were higher for TAVR than surgery at 5 years (289 [39.1%] vs 94 [15.1%]; hazard ratio, 3.30 [95% CI, 2.61-4.17]; log-rank P &amp;lt; .001), as were valve reintervention rates (27 [3.5%] vs 11 [1.9%]; hazard ratio, 2.21 [95% CI, 1.10-4.45]; log-rank P = .02), although between 2 and 5 years only 6 patients who underwent TAVR and 7 who underwent surgery required a reintervention.

Conclusions and Relevance

Among intermediate-risk patients with symptomatic severe aortic stenosis, major clinical outcomes at 5 years were similar for TAVR and surgery. TAVR was associated with superior hemodynamic valve performance but also with more paravalvular leak and valve reinterventions.