bluuebunny/crossref_metadata_2025 huggingface dataset:
miR-21-Mediated Endothelial Senescence and Dysfunction Are Involved in Cigarette Smoke-Induced Pulmonary Hypertension through Activation of PI3K/AKT/mTOR Signaling
Authors: He Bin , Shao Binxia , Cheng Cheng , Ye Zitong , Yang Yi , Fan Bowen , Xia Haibo , Wu Hao , Liu Qizhan , Zhang Jinsong
Published: May 2024

Smoking is a pathogenic factor for pulmonary hypertension (PH). Our previous study showed that serum miR-21 levels are elevated in smokers. miR-21 is considered as engaged in the PH process; however, its mechanisms remain unclear. In this investigation, we found that in the lung tissue of smoking-induced PH patients, the levels of miR-21 and aging markers (p21 and p16) were upregulated, and the function of pulmonary vascular endothelial cells was also impaired. Exposure of mice to cigarette smoke (CS) for four months caused similar changes in lung tissues and increased pulmonary arterial pressure, which were attenuated by knockout of miR-21. Further, human umbilical vein endothelial cells (HUVECs) exposed to cigarette smoke extract (CSE) revealed upregulation of miR-21 levels, depression of PTEN, activation of PI3K/AKT/mTOR signaling, an increase in senescence indexes, and enhanced dysfunction. Inhibiting miR-21 overexpression reversed the PTEN-mTOR signaling pathway and prevented senescence and dysfunction of HUVECs. In sum, our data indicate that miR-21-mediated endothelial senescence and dysfunction are involved in CS-induced PH through the activation of PI3K/AKT/mTOR signaling, which suggests that selective miR-21 inhibition offers the potential to attenuate PH.
Ejecución de gasto público por fuente de financiamiento en la Dirección de Red de Salud Yunguyo
Authors: Huacani Sucasaca Yudy , Mamani Mamani Jesús , De la Cruz Huanca Nelly Raquel , Aliaga Montoya Roberto Carlos
Published: May 2024

El estudio tuvo por finalidad explicar de qué manera se correlaciona la ejecución de gasto público y la fuente de financiamiento de la Dirección de Red de Salud Yunguyo del periodo 2013 al 2023, Perú. Se optó por un diseño metodológico no experimental, longitudinal, cuantitativo y contraste Rho de Spearman. Los resultados identificaron que la ejecución de gasto público se correlaciona significativa y positivamente con la fuente de financiamiento por recursos ordinarios [rho (11) =0.77; p < 0.001], con la fuente de financiamiento por recursos directamente recaudados [rho (11) =0.83; p < 0.001] y, con la fuente de financiamiento por recursos determinados [rho (11) =0.74; p < 0.001]. Se concluye que, ejecutar eficazmente las intervenciones priorizadas por la Dirección de Red de Salud Yunguyo están ligadas a los lineamientos del Presupuesto Público y normatividad del sector con transparencia.
Prevalence and Risk Factors of Fatigue in Adults with Stage 3 and 4 CKD
Authors: Hannan Mary F. , Tintle Nathan , Fischer Michael J. , Doorenbos Ardith Z.
Published: May 2024

Key Points

Fatigue is a common symptom experienced by adults with CKD.

Physiological, sociodemographic, psychological, and behavioral factors are associated with fatigue.

Background

Fatigue is a devastating symptom experienced by adults with CKD, but less is known about the prevalence of fatigue and factors associated with fatigue in a general population of adults with CKD. Therefore, we examined the prevalence of fatigue and identified factors associated with fatigue among a national cohort of US adults with CKD.

Methods

We utilized cross-sectional data from 1079 adults from the National Health and Nutrition Examination Survey 2007–2012 and included participants aged 18 years and older with stage 3 and 4 CKD (eGFR between 15 and 60 ml/min per 1.73 m2) who had available data evaluating fatigue. Unadjusted and adjusted logistic regression models were used to evaluate the odds of having fatigue in the context of physiological, sociodemographic, psychological, and behavioral factors.

Results

We estimated that 48% of those with CKD had fatigue. Among the risk factors examined, those with the strongest evidence of association in multivariable analyses were female sex (odds ratio [OR], 1.49; 95% confidence interval [CI], 1.02 to 2.17), pain (OR, 2.49; 95% CI, 1.57 to 3.93), poor mental health (OR, 1.97; 95% CI, 1.05 to 3.72), anxiety (OR, 1.95; 95% CI, 1.14 to 3.34), and depressive symptoms (OR, 2.58; 95% CI, 1.17 to 5.66).

Conclusions

Fatigue is a common symptom experienced by adults with CKD in the United States. Physiological, sociodemographic, psychological, and behavioral factors are associated with fatigue, with psychological factors being most strongly associated with fatigue. Future work is needed to identify interventions to mitigate fatigue and risk factors of fatigue in adults with CKD.
Modeling Grid Cell Distortions with a Grid Cell Calibration Mechanism
Authors: Strauß Daniel , Bing Zhenshan , Zhuang Genghang , Huang Kai , Knoll Alois
Published: May 2024

The medial entorhinal cortex of rodents is known to contain grid cells that exhibit precise periodic firing patterns based on the animal’s position, resulting in a distinct hexagonal pattern in space. These cells have been extensively studied due to their potential to unveil the navigational computations that occur within the mammalian brain and interesting phenomena such as so-called grid cell distortions have been observed. Previous neuronal models of grid cells assumed their firing fields were independent of environmental boundaries. However, more recent research has revealed that the grid pattern is, in fact, dependent on the environment’s boundaries. When rodents are placed in nonsquare cages, the hexagonal pattern tends to become disrupted and adopts different shapes. We believe that these grid cell distortions can provide insights into the underlying neural circuitry involved in grid cell firing. To this end, a calibration circuit for grid cells is proposed. Our simulations demonstrate that this circuit is capable of reproducing grid distortions observed in several previous studies. Our model also reproduces distortions in place cells and incorporates experimentally observed distortions of speed cells, which present further opportunities for exploration. It generates several experimentally testable predictions, including an alternative behavioral description of boundary vector cells that predicts behaviors in nonsquare environments different from the current model of boundary vector cells. In summary, our study proposes a calibration circuit that reproduces observed grid distortions and generates experimentally testable predictions, aiming to provide insights into the neural mechanisms governing spatial computations in mammals.
Intelligent Beam Optimization for Light-Sheet Fluorescence Microscopy through Deep Learning
Authors: Li Chen , Rai Mani Ratnam , Cai Yuheng , Ghashghaei H. Troy , Greenbaum Alon
Published: May 2024

Light-sheet fluorescence microscopy (LSFM) provides the benefit of optical sectioning coupled with rapid acquisition times, enabling high-resolution 3-dimensional imaging of large tissue-cleared samples. Inherent to LSFM, the quality of the imaging heavily relies on the characteristics of the illumination beam, which only illuminates a thin section of the sample. Therefore, substantial efforts are dedicated to identifying slender, nondiffracting beam profiles that yield uniform and high-contrast images. An ongoing debate concerns the identification of optimal illumination beams for different samples: Gaussian, Bessel, Airy patterns, and/or others. However, comparisons among different beam profiles are challenging as their optimization objectives are often different. Given that our large imaging datasets (approximately 0.5 TB of images per sample) are already analyzed using deep learning models, we envisioned a different approach to the problem by designing an illumination beam tailored to boost the performance of the deep learning model. We hypothesized that integrating the physical LSFM illumination model (after passing it through a variable phase mask) into the training of a cell detection network would achieve this goal. Here, we report that joint optimization continuously updates the phase mask and results in improved image quality for better cell detection. The efficacy of our method is demonstrated through both simulations and experiments that reveal substantial enhancements in imaging quality compared to the traditional Gaussian light sheet. We discuss how designing microscopy systems through a computational approach provides novel insights for advancing optical design that relies on deep learning models for the analysis of imaging datasets.
Dual-Responsive Reconfigurable Miniature Fiberbots: A Study for Vascular Embolization
Authors: Liu Xurui , Song Xin , Zhang Li
Published: May 2024

Navigating the intricate and narrow vascular pathways of the body remains a formidable challenge in vascular embolization, often limiting the maneuverability and steerability of traditional catheters. This study, by T.T. Xu and co-workers, introduces dual-responsive reconfigurable miniature fiberbots, which are capable of catheter-assisted deployment, navigation, and embolization in vascular systems. Through meticulous design and magnetic control, this work successfully validates a multistage vascular embolization approach in the renal artery of rabbits in vivo. The experiments not only overcome the existing limitations of conventional catheterization techniques but also open new avenues for minimally invasive treatments.
Link between Plant Phosphate and Drought Stress Responses
Authors: Kandhol Nidhi , Pandey Sangeeta , Singh Vijay Pratap , Herrera-Estrella Luis , Tran Lam-Son Phan , Tripathi Durgesh Kumar
Published: May 2024

The menace of drought has persistently loomed over global crop production, posing a serious threat to agricultural sustainability. Research on drought stress highlights the important role of the phytohormone abscisic acid (ABA) in orchestrating plant responses to drought conditions. ABA regulates various drought/dehydration-responsive genes, initiates stomatal closure, and influences cellular responses to drought stress. Additionally, plants employ a phosphate starvation response (PSR) mechanism to manage phosphate (Pi) deficiency, with ABA playing a role in its regulation. However, despite intensive research in these fields, the precise connection among PSRs, drought stress, and ABA signaling still needs to be determined. Recently, PSR-related gene induction has been reported to occur before the induction of ABA-responsive genes under progressive mild drought. Mild drought decreases Pi uptake and contents in plants, triggering PSRs, which play an important role in plant growth during mild drought. Both ABA-responsive and PSR-related gene expression could indicate plant perception of external moisture conditions. Thus, integrating the information regarding their associated gene expression with soil moisture contents and thermographic data can enable timely irrigation optimization to mitigate the effect of drought on crop productivity.
Scientific Discovery Framework Accelerating Advanced Polymeric Materials Design
Authors: Wang Ran , Fu Teng , Yang Ya-Jie , Song Xuan , Wang Xiu-Li , Wang Yu-Zhong
Published: May 2024

Organic polymer materials, as the most abundantly produced materials, possess a flammable nature, making them potential hazards to human casualties and property losses. Target polymer design is still hindered due to the lack of a scientific foundation. Herein, we present a robust, generalizable, yet intelligent polymer discovery framework, which synergizes diverse capabilities, including the in situ burning analyzer, virtual reaction generator, and material genomic model, to achieve results that surpass the sum of individual parts. Notably, the high-throughput analyzer created for the first time, grounded in multiple spectroscopic principles, enables in situ capturing of massive combustion intermediates; then, the created realistic apparatus transforming to the virtual reaction generator acquires exponentially more intermediate information; further, the proposed feature engineering tool, which embedded both polymer hierarchical structures and massive intermediate data, develops the generalizable genomic model with excellent universality (adapting over 20 kinds of polymers) and high accuracy (88.8%), succeeding discovering series of novel polymers. This emerging approach addresses the target polymer design for flame-retardant application and underscores a pivotal role in accelerating polymeric materials discovery.
Helicobacter pylori-Induced Angiopoietin-Like 4 Promotes Gastric Bacterial Colonization and Gastritis
Authors: Xie Rui , You Nan , Chen Wan-Yan , Zhu Peng , Wang Pan , Lv Yi-Pin , Yue Geng-Yu , Xu Xiao-Lin , Wu Jiang-Bo , Xu Jing-Yu , Liu Si-Xu , Lü Mu-Han , Yang Sheng-Qian , Cheng Ping , Mao Fang-Yuan , Teng Yong-Sheng , Peng Liu-Sheng , Zhang Jin-Yu , Liao Ya-Ling , Yang Shi-Ming , Zhao Yong-Liang , Chen Weisan , Zou Quan-Ming , Zhuang Yuan
Published: May 2024

Helicobacter pyloriinfection is characterized as progressive processes of bacterial persistence and chronic gastritis with features of infiltration of mononuclear cells more than granulocytes in gastric mucosa. Angiopoietin-like 4 (ANGPTL4) is considered a double-edged sword in inflammation-associated diseases, but its function and clinical relevance inH. pylori-associated pathology are unknown. Here, we demonstrate both pro-colonization and pro-inflammation roles of ANGPTL4 inH. pyloriinfection. Increased ANGPTL4 in the infected gastric mucosa was produced from gastric epithelial cells (GECs) synergistically induced byH. pyloriand IL-17A in acagA-dependent manner. Human gastric ANGPTL4 correlated withH. pyloricolonization and the severity of gastritis, and mouse ANGPTL4 from non-bone marrow-derived cells promoted bacteria colonization and inflammation. Importantly,H. pyloricolonization and inflammation were attenuated inIl17a−/−,Angptl4−/−, andIl17a−/−Angptl4−/−mice. Mechanistically, ANGPTL4 bound to integrin αV (ITGAV) on GECs to suppress CXCL1 production by inhibiting ERK, leading to decreased gastric influx of neutrophils, thereby promotingH. pyloricolonization; ANGPTL4 also bound to ITGAV on monocytes to promote CCL5 production by activating PI3K–AKT–NF-κB, resulting in increased gastric influx of regulatory CD4+T cells (Tregs) via CCL5–CCR4-dependent migration. In turn, ANGPTL4 induced Tregproliferation by binding to ITGAV to activate PI3K–AKT–NF-κB, promotingH. pylori-associated gastritis. Overall, we propose a model in which ANGPTL4 collectively ensuresH. pyloripersistence and promotes gastritis. Efforts to inhibit ANGPTL4-associated pathway may prove valuable strategies in treatingH. pyloriinfection.
A Universal Approach Toward Intrinsically Flexible All-Inorganic Perovskite-Gel Composites with Full-Color Luminescence
Authors: Wang Dourong , Cui Jingjing , Feng Yang , Guo Yunlong , Zhang Jie , Bao Yaqi , Deng Haoran , Chen Ruiqian , Kang Xinxin , Zhang Biao , Song Lin , Huang Wei
Published: May 2024

The combination of all-inorganic perovskites (PVSKs) and polymers allows for free-standing flexible optoelectronic devices. However, solubility difference of the PVSK precursors and concerns over the compatibility between polymer carriers and PVSKs imply a great challenge to incorporate different kinds of PVSKs into polymer matrices by the same manufacturing process. In this work, PVSK precursors are introduced into poly(2-hydroxyethyl acrylate) (PHEA) hydrogels in sequence, in which the PVSK-gel composites are achieved with full-color emissions by simply varying the precursor species. Moreover, it is found that CsBr has a higher interaction energy with the (111) plane of CsPbBr
3
than the (110) plane; thus, the CsPbBr
3
crystals with a shape of truncated cube and tetragon are observed during the CsPbBr
3
–Cs
4
PbBr
6
phase transition over time. The PVSK-gel composites feature excellent bendability, elasticity, and stretchable deformation (tensile strain > 500%), which allows for 3D printing emissive customized stereoscopic architectures with shape-memory features.
Cytochrome P450 Enzyme Design by Constraining the Catalytic Pocket in a Diffusion Model
Authors: Wang Qian , Liu Xiaonan , Zhang Hejian , Chu Huanyu , Shi Chao , Zhang Lei , Bai Jie , Liu Pi , Li Jing , Zhu Xiaoxi , Liu Yuwan , Chen Zhangxin , Huang Rong , Chang Hong , Liu Tian , Chang Zhenzhan , Cheng Jian , Jiang Huifeng
Published: May 2024

Although cytochrome P450 enzymes are the most versatile biocatalysts in nature, there is insufficient comprehension of the molecular mechanism underlying their functional innovation process. Here, by combining ancestral sequence reconstruction, reverse mutation assay, and progressive forward accumulation, we identified 5 founder residues in the catalytic pocket of flavone 6-hydroxylase (F6H) and proposed a “3-point fixation” model to elucidate the functional innovation mechanisms of P450s in nature. According to this design principle of catalytic pocket, we further developed a de novo diffusion model (P450Diffusion) to generate artificial P450s. Ultimately, among the 17 non-natural P450s we generated, 10 designs exhibited significant F6H activity and 6 exhibited a 1.3- to 3.5-fold increase in catalytic capacity compared to the natural CYP706X1. This work not only explores the design principle of catalytic pockets of P450s, but also provides an insight into the artificial design of P450 enzymes with desired functions.
Bacillus siamensis
Targeted Screening from Highly Colitis-Resistant Pigs Can Alleviate Ulcerative Colitis in Mice
Authors: Fang Xiuyu , Liu Haiyang , Du Yongqing , Jiang Lin , Gao Feng , Wang Zhengyi , Chi Zihan , Shi Baoming , Zhao Xuan
Published: May 2024

Ulcerative colitis (UC) is often accompanied by intestinal inflammation and disruption of intestinal epithelial structures, which are closely associated with changes in the intestinal microbiota. We previously revealed that Min pigs, a native Chinese breed, are more resistant to dextran sulfate sodium (DSS)-induced colitis than commercial Yorkshire pigs. Characterizing the microbiota in Min pigs would allow identification of the core microbes that confer colitis resistance. By analyzing the microbiota linked to the disease course in Min and Yorkshire pigs, we observed that
Bacillus
spp. were enriched in Min pigs and positively correlated with pathogen resistance. Using targeted screening, we identified and validated
Bacillus siamensis
MZ16 from Min pigs as a bacterial species with biofilm formation ability, superior salt and pH tolerance, and antimicrobial characteristics. Subsequently, we administered
B. siamensis
MZ16 to conventional or microbiota-deficient BALB/c mice with DSS-induced colitis to assess its efficacy in alleviating colitis.
B. siamensis
MZ16 partially counteracted DSS-induced colitis in conventional mice, but it did not mitigate DSS-induced colitis in microbiota-deficient mice. Further analysis revealed that
B. siamensis
MZ16 administration improved intestinal ecology and integrity and immunological barrier function in mice. Compared to the DSS-treated mice, mice preadministered
B. siamensis
MZ16 exhibited improved relative abundance of potentially beneficial microbes (
Lactobacillus
,
Bacillus
,
Christensenellaceae R7
,
Ruminococcus
,
Clostridium
, and
Eubacterium
), reduced relative abundance of pathogenic microbes (
Escherichia-Shigella
), and maintained colonic OCLN and ZO-1 levels and IgA and SIgA levels. Furthermore,
B. siamensis
MZ16 reduced proinflammatory cytokine levels by reversing NF-κB and MAPK pathway activation in the DSS group. Overall,
B. siamensis
MZ16 from Min pigs had beneficial effects on a colitis mouse model by enhancing intestinal barrier functions and reducing inflammation in a gut microbiota-dependent manner.
Retrieval of Interior Structure of Asteroids with the Low-Frequency Telescope DART
Authors: Zhou Honghui , Yan Jingye , Lan Ailan , Deng Xiang , Wu Lin
Published: May 2024

Understanding the internal structure of asteroids is crucial for deciphering their formation and establishing defenses against potential hazards. The Daocheng Radio Telescope (DART), a recently constructed interferometric array designed for low-frequency Sun imaging, presents a promising tool for probing asteroid interiors. With a substantial 1-km array aperture and an equivalent receiving area of approximately 8,850 m
2
, DART plays a vital role in diagnosing asteroid internal structures. This study introduces an electromagnetic wave scattering model tailored to asteroids within DART’s operational frequency range (150 to 450 MHz). Ground-based radar detection can unveil multiple facets of these celestial bodies by leveraging low-frequency waves’ penetrating capabilities and capitalizing on asteroids’ rotational dynamics. Through simulations capturing the characteristics of low-frequency waves traversing a layered model and interacting with internal structures, we propose an electromagnetic scattering model of asteroids. Our results underscore DART’s potential as a crucial instrument for discerning the internal structure of near-Earth objects. We first formulate an asteroid model through celestial impact models, dimensional analysis, and data fitting to achieve this. Subsequently, we derive an electromagnetic scattering model using geometric optics and a propagation model for lossy mediums. Simulations demonstrate that morphology and internal structure dictate the distribution of scattered waves, with forward and backscattered waves providing comprehensive internal structure information over a rotation cycle. Furthermore, we observe that alterations in electromagnetic wave frequency induce changes in the scattering characteristics, prompting the convenience of employing multiple frequencies for retrieving detailed information about an asteroid’s internal medium and structure. This multidimensional approach positions DART as a promising asset in advancing our understanding of asteroid interiors, offering valuable insights for scientific inquiry and hazard mitigation strategies.
Green Nudging in Unternehmen
Authors: Kraft Michael Hans Gino , Binder Patrick , Scherer Lukas
Published: May 2024

Green Nudging ist ein verhaltensorientierter Ansatz, um Personen zu ökologischem Verhalten zu ermuntern. Nudging basiert auf Erkenntnissen aus der Verhaltensökonomie und -psychologie. Dabei werden subtile Anreize und Systeme auf informationeller, kontextbezogener oder prozeduraler Ebene eingesetzt. Ziel ist es, individuelle Entscheidungen zu beeinflussen, ohne dabei auf Zwang oder Verbote zurückzugreifen. Green Nudging weckt zunehmend das Interesse von Unternehmen, die ihr Engagement für Umweltschutz und Nachhaltigkeit verstärken wollen. Was aber bedeutet Green Nudging im Unternehmenskontext und wie können Unternehmen von Green Nudging profitieren, um ihrer ökologischen Verantwortung gerecht zu werden? Der Beitrag erläutert anhand von Beispielen verschiedene Ansätze von Green Nudging und ihre möglichen Auswirkungen. Es werden Tipps für die Umsetzung gegeben und auch ethische Überlegungen berücksichtigt.
Green Organizations und Kooperationen
Authors: Lienbacher Eva , Vallaster Christine , Huis Cornelia
Published: May 2024

Der Wandel des Wirtschaftssystems durch neue Gesetze und den steigenden Anspruch der Kund:innen treibt die Entwicklung von Green Organizations oder hybriden Unternehmen voran. Hybride Unternehmen integrieren verschiedene Logiken, indem sie Profit mit sozialen und/oder ökologischen Zielen gleichsetzen. Der Druck im Zuge der Klimakrise begünstigt Kooperationen zwischen hybriden und konventionellen Unternehmen. Die Studie, die in fünf Ländern durchgeführt wurde und Entscheidungsträger:innen aus hybriden, Non-Profit- und For-Profit-Organisationen einschloss, hebt die entscheidende Rolle individueller Mindsets bei der Gestaltung von Kooperationen hervor. Verschiedene Archetypen beeinflussen die Präferenzen für Kooperationspartner. Als sinnvoll erweisen sich Partnerschaften auf Augenhöhe, welche die Vielfalt der Organisationsformen als Chance begreifen.
Nachhaltige Geschäftsmodellmuster als Innovationstreiber
Authors: Wunder Thomas
Published: May 2024

Nachhaltige Geschäftsmodellmuster beschreiben praxiserprobte Ansätze zur Verknüpfung von wirtschaftlicher, sozialer und ökologischer Wertschöpfung. Bei der Entwicklung eines nachhaltigen Geschäftsmodells liefern sie Impulse für die Ideengenerierung und unterstützen den Innovationsprozess. Ausgangspunkt hierfür können ESG-Themen aus einer doppelten Wesentlichkeitsanalyse der Corporate Sustainability Reporting Directive (CSRD) sein.
Neuromyelitis in a Patient with Rheumatoid Arthritis: A Case Report
Authors: Qiang Fuyong , Li Zhi , Chen Lanfang , Xuan Dan , Sheng Jun
Published: May 2024

A patient with longstanding rheumatoid arthritis (RA) complained of spinal cord symptoms after RA relapse. Contrast MRI demonstrated neuromyelitis in the upper thoracic spinal cord, and anti-aquaporin-4 (anti-AQP4) antibody was positive in the serum and cerebrospinal fluid (CSF). Neuromyelitis optica spectrum disorder (NMOSD) was diagnosed after excluding central nervous system (CNS) infection and tumor, and spinal cord symptoms were relieved after high dose of glucocorticoid and immunosuppressant were initiated for treatment.
Inflammatory Linear Verrucous Epidermal Nevus with Systemic Manifestations
Authors: Адаскевич В.П. , Катина М.А. , Пушкарская И.А. , Лесничая О.В.
Published: May 2024

Воспалительный линейный веррукозный эпидермальный невус (ILVEN – Inflammatory Linear Verrucous Epidermal Nevus) – редкий тип эпидермального невуса. Эпидермальные невусы представляют собой гамартоматозные поражения, которые обычно присутствуют при рождении, но могут возникнуть в детском возрасте и редко появляются у взрослых. У каждого третьего пациента с эпидермальными невусами наблюдаются поражения других систем организма. Существует четыре различных синдрома эпидермального невуса, распознаваемых по различным типам ассоциированных эпителиальных невусов: линейный сальный невус, линейный комедоновый невус, линейный эпидермальный невус и воспалительный линейный веррукозный эпидермальный невус (ILVEN). Каждый тип можно рассматривать как часть синдрома с другими системными проявлениями. Мы сообщаем о редком случае синдрома ILVEN у 10-летней пациентки с разнообразным спектром нарушений (кожа, опорно-двигательный аппарат, сосудистая мальформация, эндокринологическая патология), что демонстрирует полиморфную картину этого состояния.

Inflammatory Linear Verrucous Epidermal Nevus (ILVEN) is a rare type of epidermal nevus. Epidermal nevi are hamartomatous lesions that are usually present at birth, but can occur in childhood and rarely appear in adults. Every third patient with epidermal nevi has lesions in other body systems. There are four different epidermal nevus syndromes, recognized by different types of associated epithelial nevi: linear sebaceous nevus, linear comedonic nevus, linear epidermal nevus, and inflammatory linear verrucous epidermal nevus (ILVEN). Each type can be considered as part of a syndrome with other systemic manifestations. We report a rare case of ILVEN syndrome in a 10-year-old patient with a diverse range of disorders (skin, musculoskeletal system, vascular malformation, endocrinological pathology), which demonstrates a polymorphic picture of this condition.
REFINAMIENTO AL METODO DE SELECCION MASAL MODERNO
Authors: Méndez  R. Ignacio
Published: May 2024

Se discuten las bases teóricas para una mejor eliminación de los efectos ambientales, al seleccionar características métricas en los cultivos agrícolas, considerando que los efectos ambientales en su mayoría, afectan una función de tendencia geográfica en la produc­tividad de las plantas individuales. Existen antecedentes de lo anterior en muchos ensayos de uniformidad. Se propone un proce­dimiento mediante el cual, es posible estimar los efectos ambienta­les sistemáticos, usando los llamados promedios móviles. Si a la producción individual por planta se le substrae la estimación de efectos ambientales sistemáticos, se tendrá una estimación de los efectos genéticos y efectos ambientales no sistemáticos. Estos últimos se consideran de poca magnitud y con media cero al consi­derar muchas plantas. De esta manera se obtiene un estimador in­sesgado a los efectos genéticos, permitiendo de este modo la se­lección de plantas con constituciones genéticas más favorables al rendimiento.
RESPUESTA A LA DEFOLIACION DEL HIBRIDO DE MAIZ H-204 BAJO CONDICIONES DE TEMPORAL DE AGUASCALIENTES
Authors: Del Campo Valle Salvador Martín , Cueto Parra Javier
Published: May 2024

Para conocer la respuesta del hibrido precoz de maíz (Zea mays L.) H-204 a la defoliación y estudiar algunas de sus relaciones entre la fuente y la demanda fisiológicas, en una área con temporal deficiente, como es la región de El Llano, Aguascalientes, se le aplicaron cuatro niveles de defoliación (0, 25, 50 y 75X, en relación a la longitud de las hojas), en dos formas (al momento de aparecer la ligula en cada hoja y al momento de la floración). En la primera forma la defoliación redujo el rendimiento de grano hasta en 74X con relación al testigo no defoliado, 111ientras que la defoliación al momento de la floración no afectó significativamente dicho rendimiento. En ambas formas el rendimiento biológico se redujo significativamente, aunque la reducción fue mayor en el primer caso. El índice de cosecha se redujo significativamente al incrementarse los niveles de defoliación cuandoaparecía la ligula, mientras que la defoliación al momento de la floración, lo aumentó significativamente.
DIFERENCIACION VARIETAL DE MAICES "CRIOLLOS" DE LA RAZA TUXPEÑO DEL ESTADO DE VERACRUZ, MEXICO
Authors: Caballero Hernández Filiberto
Published: May 2024

En el área tropical humeda de México existen variedades "criollas" regionales que se han colectado pero aún no se han evaluado, caracterizado y seleccionado, las cuales pueden servir como fuente de plasma germinal para programas de mejoramiento genéticode maíz (Ze& mays L.). Con el objeto de conocer la variación de 171 variedades "criollas" colectadas en el área tropical humeda del estado de Veracruz, se realizó un experimento en el Campo Agrícola Experimental Cotaxtla, Ver., en el ciclo de temporal de 1981. Mediante el uso de Taxonomía Numérica sobre 19 caracteres vegetativos y agronómicos, se diferenciaron 16 grupos al nivel de 0.80de disimilitud, de los cuales Los identificados como 1, 3, 4, 5 y 6 agruparon a la mayoría de las variedades; los demás incluyeron de dos e siete colectas cada uno, excepto el grupo 16 que estuvo formado por un solo material. Se presentó una amplia variación tanto genética como fenotípica, de donde se pueden tomar diversas varieades "criollas" con caracteristicas deseables para los   de mejoramiento genético de maíz
PROBLEMAS CON LINEAS ENDOGAMICAS. I. INCREMENTO DE SEMILLA CON DOS Y CUATRO PLANTAS PROGENITORAS
Authors: Márquez Sánchez Fidel
Published: May 2024

Se discuten tres formas de calcular la endogamia (fórmula de endogamia en un sistema regular de apareamiento, coeficiente de homocigosis y fórmula de endogamia en variedades sintéticas) que se genera por un primer incremento de semilla con 2 o 4 plantas de la lfnea original para producir la semilla básica, y por un segundo incremento en esta última para producir la semilla registrada, en cuatro tipos de líneas endogámicas en maíz (Zea mays L.): autofecundadas, fraternales, mesofraternales y retrocruzadas. Se demuestra que sólo con líneas autofecundadas y retrocruzadas los tres métodos arrojan los mismos resultados de endogamia para dosincrementos, aunque en el del coeficiente de homo· cigosis esto es circunstancial, y con la fórmula de endogamia en un sistema regular de apareamiento se tiene que hacer un razonamiento a posteriori para que sea válida. con líneas fraternales y mesofraternales solo la fórmula de endogamia en variedades sintéticas produce el res~ltado correcto, con base en el tipo de cruza usado para hacer el incremento.
SELECCION DE PLANTAS REPRODUCTORAS DE PALMA DE COCO
Authors: Hernández-Roque Felícitos , Gómez-Montiel Noel
Published: May 2024

En 1979 se inició un estudio del germoplasma de palma de coco, Cocos nucifera L. , en los dos tipos existentes en el país: los criollos altos y los criollos enanos, ambos de origen malayo. Para esto se hizo un recorrido en el tramo de la costa del Pacífico comprendido entre Barra de Navidad, Jal. y Pinotepa Nacional, Oax. observándose que el rendimiento promedio anual es de 10 kg de copra por árbol, en varias huertas que tuvieron una superficie mínima de tres hectáreas con palmas de la misma edad. Se eligieron para hacer estudios de selección en criollo alto, a dos plantaciones de Lázaro Cárdenas, Mich. y otra de Tecpan de Galeana, Gro., y para el coco enano una de Tecomán, Col. En estas plantaciones se practicó selección masal durante un año en el coco enano y tres años en el tipo alto. Para 1986 se tenían seleccionadas 27 plantas altas (presión de selección del 3%) con un rendimiento medio anual de 37.8 kg de copra por palma, así como 29 palmas enanas (presión de selección del 9%) con un rendímiento medio anual de 47.1 kg de copra por palma.
EVALUACION DE HIBRIDOS RECOBRADOS DE MAIZ EN LA ZONA DEL BAJIO DERIVADOS DE H-3091
Authors: Covarrubias-Prieto Jorge
Published: May 2024

Con el objeto de obtener híbridos recobrados de maíz (Zea mays L.) que pudieran sustituir al híbrido original H-309, por ser superiores a éste en rendimiento, caracteres agronómicos y de adaptación más amplia, se derivaron sublíneas a partir de cadauna de las líneas que integran el híbrido H-309; híbrido de buena adaptación para siembras de medio riego o con buen temporal en la zona del Bajío. Las sublíneas de cada línea progenitora de la cruza simple hembra fueron evaluadas usando como probador a la cruza simple macho del mismo híbrido y viceversa. Con las sublíneas seleccionadas se formaron 225 híbridos de cuatro líneas que se evaluaron en once ambientes (cinco años en Roque, Gto., y cuatro años en cuatro localidades del estado de Jalisco). Se identificaron 37 híbridos recobrados superiores en rendimiento al H-309 en un 14% en promedio. Además, tuvieron mejor comportamiento en la zona central de Jalisco que en Guanajuato. La precocidad fue similar en ambos materiales, pero la sanidad fue mayor en los híbridos recobrados. Esto demuestra que es posible obtener nuevos materiales con mayor rendimiento y mejores características a partir de material comercial, en los que aún existe suficiente variabilidad genética que es posible aprovechar en nuevas combinaciones híbridas más específicas.
RENDIMIENTO DE GRANO Y CARACTERÍSTICAS AGRONÓMICAS EN GERMOPLASMA DE MAÍZ DE VALLES ALTOS DE MÉXICO
Authors: Hernández-Casillas Juan Manuel , Esquivel-Esquivel Gilberto
Published: May 2024

El objetivo de este estudio fue identificar germoplasma de maíz (Zea mays L.) de alto rendimiento y seleccionar las mejores cruzas con respecto a tres híbridos comerciales, en los valles altos de la Mesa Central de México. Se evaluaron 18 cruzas entre líneas y 38 cruzas entre materiales criollos y dos probadores, más tres híbridos comerciales como testigos. El experimento se estableció durante el ciclo primavera-verano en Santa Lucía de Prías, Texcoco, Estado de México, en 2002 y 2003. Las variables evaluadas fueron: días a floración, altura de planta, altura de mazorca, longitud de mazorca, diámetro de mazorca, número de hileras por mazorca, rendimiento de grano, índice de grano y sanidad de mazorca. Estas características se analizaron bajo un diseño de bloques completos al azar con arreglo factorial y tres repeticiones. Se descubrieron 10 cruzas sobresalientes en cada grupo con rendimientos que fluctúan de 5.0 a 9.3 t ha-1 en el primero y de 5.9 a 9.4 t ha-1 en el segundo. Entre el germoplasma sobresaliente se encontraron cruzas entre líneas autofecundadas y cruzas de criollos con un probador, cuyos rendimientos de grano y otros atributos de importancia fueron similares a los de los testigos.
Resonanz in der Peer-Eingewöhnung
Authors: Fink Heike
Published: May 2024

Die Autorin adressiert ihre Resonanzüberlegungen an der Peer-Eingewöhnung in der Kindertagesbetreuung. Mit Bezugnahme auf das Tübinger Modell der Eingewöhnung reflektiert sie den Stellenwert von Resonanz für die Ausgestaltung des Eingewöhnungsprozesses und den Beziehungsaufbau zwischen Fachkraft und Kind einerseits und den Kindern untereinander andererseits. (DIPF/Orig.)
Donald Trump ou la fausse présidence impériale
Authors: Burtin Olivier
Published: May 2024

Depuis la publication du livre éponyme d’Arthur Schlesinger Jr. En 1973, le concept de « présidence impériale » a souvent été utilisé pour critiquer les excès de l’exécutif aux États‑Unis. Ce fut tout particulièrement le cas pour la présidence de Donald Trump, qui a souvent été décrite comme marquant une rupture historique de par son mépris des normes institutionnelles, ses multiples conflits d’intérêts, ou sa tendance autoritaire marquée. Avec un peu de recul, le bilan de son administration semble toutefois témoigner d’un président plus en position de faiblesse que de force. En replaçant le mandat de Trump dans une perspective historique, cet article démontre en effet que, loin de s’être démarqué par sa puissance, le 45e président dût en réalité faire face aux mêmes tendances de fond qui avaient contribué depuis plusieurs décennies déjà à affaiblir sa fonction. L’omniprésence de Trump dans les médias cachait donc un président qui était loin d’être omnipotent.
Les caucus du Parti démocrate de l’Iowa (2020) : faux départ ou fin de partie ?
Authors: Ricaud Raphael
Published: May 2024

Cet article s’intéresse aux caucus démocrates de l’Iowa (hiver 2019‑2020). Ancrée dans le terroir et dans le temps long, la période précédant les caucus est censée donner davantage de latitude aux électeurs et aux candidats que les autres phases de la campagne présidentielle. En avant‑première de la course à l’investiture, les caucus de l’Iowa sont néanmoins fortement contraints par des attentes nationales.Afin d’explorer cette tension entre les forces locales et nationales à l’œuvre dans l’organisation des caucus, nous procédons à une mise en contexte de leur fonctionnement et à leur système de scrutin complexe. Nous mentionnons notamment la spécificité géographique et démographique de l’Iowa. Dans un deuxième temps, nous observons les techniques de communication des différents candidats. Force est de constater qu’en lieu et place d’un véritable discours politique, les candidats optent majoritairement pour un spectacle aux contraintes normatives fortes. Enfin, nous nous intéressons aux stratégies divergentes de deux candidats centristes en 2019‑2020 : Pete Buttigieg et Joe Biden. L’un fit le choix de l’ancrage local et du temps long tandis que l’autre considéra l’Iowa comme une étape parmi tant d’autres. Pour conclure, nous constatons que la spécificité de l’Iowa n’entrave en rien la réussite d’un candidat qui n’aurait su briller dans cet État, à condition que celui‑ci jouisse déjà d’une renommée nationale et d’une longue expérience politique.
Le Minnesota et la présidentielle de 2020 : une victoire en trompe-l’œil pour les démocrates
Authors: Azuelos Martine , Ghorra-Gobin Cynthia
Published: May 2024

On parlait peu du Minnesota avant le décès de George Floyd à Minneapolis en mai 2020. Le vaste mouvement de révolte qui s’est ensuivi a eu des effets durables sur le déroulement de la campagne de 2020 et sur le résultat des différents scrutins. Dans ce contexte, ce « petit » État est intéressant à plus d’un titre. D’abord, en dépit de spécificités propres, il est le miroir d’enjeux qui se sont posés au plan national et dans le Midwest pendant la campagne. Étudier les évolutions économiques et sociales qui l’ont marqué au cours des trois dernières décennies aide par ailleurs à comprendre le vote de ses électeurs, tant à la présidentielle qu’aux élections aux Congrès des États‑Unis et à la législature de l’État. La reconfiguration de ses territoires par l’économie de la connaissance et la mondialisation donne notamment à lire la progression du vote républicain dans le Greater Minnesota comme le reflet de forces polarisantes qui ne sont pas prêtes de s’estomper. Ainsi la victoire de Joe Biden au Minnesota peut‑elle apparaître comme une victoire en trompe-l’œil pour les démocrates.
DESEMPENHO DE CRIANÇAS NO TESTE DE INTELIGÊNCIA MATRIZES PROGRESSIVAS COLORIDAS DE RAVEN
Authors: Perissinotto Rodrigo , Resende Ana Cristina , Borges Nadyene Moreira de Souza , Assis Ana Luiza de Magalhães
Published: May 2024

O teste Matrizes Progressivas Coloridas de Raven avalia a inteligência fluida ou geral em crianças. Como essa é uma competência importante em relação a várias decisões que afetam a vida de alguém, o objetivo desse estudo foi comparar o desempenho de crianças no teste Matrizes Progressivas Coloridas de Raven em relação ao sexo, tipo de escola e faixas etárias, para ao final apresentar normas de desempenho diferenciadas para cada grupo de crianças. Participaram 431 crianças com idade de 7 a 11 anos. As evidências de precisão foram avaliadas por meio do alfa de Cronbach e correlação bisserial. Para comparar os resultados considerando sexo, tipo de escola e idade foram utilizados os testes de Mann-Whitney e Kruskal-Wallis. Adicionalmente, utilizou-se correlação de Spearman para observar a relação entre a idade e desempenho no teste. O alfa de Cronbach total foi 0,874. A correlação bisserial indicou que a série B apresentou as maiores correlações com a variável latente. Não houve diferença no desempenho dos alunos quanto ao tipo de escola e sexo, contudo houve correlação positiva moderada (r = 0,60) entre idade e desempenho.  Ao final, as normas para interpretação do teste foram elaboradas de acordo com cinco faixas etárias e por meio de percentis.
A PROPAGAÇÃO DO CYBERBULLYING PELO APLICATIVO WHATSAPP: REFLEXÕES JURÍDICAS
Authors: Silva Baia Lhais
Published: May 2024

Resumo: Este artigo busca esclarecer sobre o tema cyberbullying e WhatsApp, abordando no que consiste este tipo de bullying eletrônico, qual sua relação com as redes sociais, com o WhatsApp em específico, e quais seus reflexos jurídicos. A abordagem deste tema gera discussões atuais sobre liberdade de expressão no meio eletrônico e o dano moral em favor das vítimas. Portanto, em seguimento metodológico das linhas jurídico-dogmático e jurídico-social, investiga-se este trabalho com o objetivo de elucidar a importância do esclarecimento do cyberbullying na atual conjuntura tecnológica.
Docência On Line em Tempos de Pandemia da COVID-19: Relatos de Experiências Realizadas em um Curso de Bacharelado em Sistemas de Informação
Authors: Silveira Sidnei Renato , Bertolini Cristiano , Parreira Fábio José , Bernardino da Cunha Guilherme , Martini Bigolin Nara
Published: May 2024

Este artigo apresenta um relato de experiências compreendendo as práticas pedagógicas realizadas de forma on line, em um curso de Bacharelado em Sistemas de Informação, durante o isolamento social devido à pandemia da COVID-19. Neste contexto, as atividades relacionadas aos processos de ensino e de aprendizagem precisaram ser repensadas, aplicando-se Tecnologias Digitais da Informação e da Comunicação (TDICs) e metodologias ativas de aprendizagem. Os resultados apontam que as ferramentas mais utilizadas pelos docentes foram as vídeoaulas, de forma on line (lives) ou gravadas e disponibilizadas posteriormente aos alunos, além do Ambiente Virtual de Aprendizagem Moodle.
Hacia el futuro de la cirugía: Análisis descriptivo de la implementación del primer centro de cirugía robótica en un hospital público nacional
Authors: Larenas Huguet Francisca , Acuña Acuña Bruno Ignacio , López Miguel , Segovia Sofía , Sánchez Catherine , Fullá Juan
Published: May 2024

Objetivo: El Hospital Clínico San Borja Arriarán (HCSBA) es el primer hospital público en Chile en adoptar el sistema de cirugía robótica Da Vinci®. Este estudio busca caracterizar la población atendida, describir los resultados clínicos de las cirugías y analizar sus costos. Materiales y métodos: Se analizó una base de datos descriptiva incluyendo variables clínicas y económicas de todas las cirugías robóticas realizadas entre octubre de 2022 y octubre de 2023 en 7 especialidades quirúrgicas. Se describieron variables cuantitativas mediante media y desviación estándar y variables cualitativas mediante frecuencias y porcentajes. Resultados: Se analizaron 186 cirugías de pacientes con edad promedio de 57,98 (DE: 20,31) años. Se observó al menos una comorbilidad en el 74,19% de los pacientes, destacando como las más frecuentes la hipertensión arterial y la diabetes mellitus tipo 2. Las cirugías cardiacas mostraron el mayor porcentaje de complicaciones intra (29%) y postoperatorias (43%), el mayor volumen de sangrado intraoperatorio (971 ml, DE: 690,6), la mayor duración (180,57 min, DE: 56,9), más días de hospitalización (8,29 días, DE: 2,3) y más días de licencia médica (25 días, DE: 3,3). El costo promedio de las cirugías osciló entre $2,9 y $4,7 millones de pesos chilenos (CLP), siendo las cardíacas y urológicas las más costosas (promedio CLP $4,7 y $3,7 millones, respectivamente). Discusión y conclusión: La implementación y uso de la cirugía robótica en HCSBA ha sido factible. Se podría reducir costos a varios niveles, por lo que se requieren estudios de costo-efectividad, que permita comparar la cirugía robótica con otras técnicas.
Perceptual Learning for Promoting Design Thinking in Space Design Education
Authors: Nagatomo Daisuke
Published: May 2024

The application of real-time visualization and virtual reality (VR) technology was examined to promote students’ design thinking in space design education. Learning space design, such as architecture and interior design, takes a series of iterations of training to nurture their imagination of how to translate their idea into a physical format. While design thinking refers to ideating, prototyping, testing, and implementing, educational methods for space design linearly provide students with an opportunity by employing this procedure. Traditionally, academic tools for space design education have been drawing, model making, and, recently, computer rendering. However, these methods differ from prototyping in design thinking regarding physical experience. It lacks the problem-finding, and cannot articulate the feedback system. Thus, this study was carried out to implement perceptual learning and training by data processing via acquired visual experience. With real-time visualization and VR technologies, spatial design prototypes were developed virtually. After the perceptual learning, the result evaluation was carried out with a qualitative analysis of the participants and a quantitative analysis of pre-course and after-course questionnaires. Afterward, the teaching experience of perceptual learning and findings were discussed.
Penggunaan Senjata Api Menghadapi Tindak Kriminal: Tiga Variasi Pertimbangan dan Keputusan Memilih
Authors: Runturambi A. Josias Simon
Published: May 2024

Tulisan ini merupakan hasil penelitian deskriptif tentang pertimbangan dan keputusan menggunakan senjata api yang diambil oleh petugas kepolisian menghadapi tindak kriminal. Studi ini dilakukan dengan mengambil beberapa informan dari petugas kepolisian Indonesia. Hasil riset menunjukkan penggunaan senjata api di lapangan sangat variatif, bergantung 3 aspek utama yaitu situasi saat penangkapan, karakter pelaku kejahatan dan aturan formal yang berlaku. Selain itu karateritik sosial budaya wilayah terjadinya tindak kriminal menjadi faktor pemicu penggunaan senjata api.
Peran Negara-Negara Asia Tenggara dalam Menghadapi ISIS
Authors: Mukhtar Sidratahta
Published: May 2024

Asia Tenggara sudah menjadi pusat perkembangan kelompok militan dan terorisme dalam satu dekade terakhir. Di berbagai wilayah di Asia Tenggara kerapkali terjadi pergerakan kelompok terorisme, seperti di Mindanao Filipina, Thailand Selatan, Malaysia dan Indonesia. Antara lain, Filipina kini menjadi arena penting bagi kelompok terorisme baik secara domestic, regional dan internasional dalam 20 tahun terakhir. Sejak pada tahun 1994, Jamaah Islamiyah (JI) mendirikan camp latihan Hudaibiyah menjadi tempat training teroris di Malaysia, Singapura, Thailand, Indonesia dan dari Timur Tengah. Banyak instruktur Camp latihan militer kelompok teroris itu berasal dari Indonesia dan Timur Tengah yang memiliki afiliasi dengan Al Qaeda. Karena itu, sejak awal para pemimpin ASEAN sudah menyadari dan mmebangun kerjasama regional dalam menghadapi ancaman terorisme.