bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Consumption Patterns on the Generation of Municipal Solid Waste in China: Evidences from Provincial Data
Authors: Liu Jinhui , Li Qing , Gu Wei , Wang Chen
Published: May 2019

Municipal solid waste (MSW) is the derivative of urban development and it is harmful to the environment and residents’ health. But with sustainable MSW management, MSW can be applied as an important renewable energy. In order to achieve sustainable MSW management, it is necessary to understand the mechanism of MSW generation. Consumption patterns differ in various regions of China, which make the influencing factors of MSW have unique characteristics. To explore the factors influencing MSW generation in China, this study builds a global model based on the panel data of 30 Chinese provinces. Considering regional heterogeneity, provinces are clustered into three groups according to economic and consumption indicators. Each group has its own local model of MSW generation. The results show that household expenditure on housing and the tertiary industry proportion show opposite impacting directions in high-level and low-level provinces. Finally, with the combination of the grey model (1,1) (GM(1,1)) and multiple linear regression (MLR), we find that developing provinces will generate more MSW than developed regions. According to this, different provinces should control MSW by optimizing consumption pattern and efficient fiscal expenditure, and developing provinces should pay attention to MSW management and learn from the experience of developed provinces.
Health-Related Quality of Life of People with Self-Reported Hypertension: A National Cross-Sectional Survey in China
Authors: Yao Qiang , Liu Chaojie , Zhang Yaoguang , Xu Ling
Published: May 2019

This study aimed to determine the health-related quality of life (HRQoL) of people with self-reported diagnosed hypertension and its determinants in China. Data was obtained from the 5th National Health Services Survey. The HRQoL of the respondents who were 15 years or older was assessed with the EQ-5D-3L utility index and visual analogue scale (VAS), and compared between those with (n = 30,063) and without (n = 158,657) self-reported hypertension. Multivariate logistic regression, Tobit regression, and linear regression models were established to identify predictors of HRQoL. A difference of half standard deviation was deemed as minimal clinically important difference (MCID) for the utility index (0.03). The respondents with self-reported hypertension were more likely to report problems in the five dimensions (Adjusted Odds Ratio = 1.43–1.70) of the EQ-5D-3L, resulting in a significant lower utility index (β = −0.04) and VAS scores (β = −3.22) compared with those without self-reported hypertension, and the difference of the utility index exceeded MCID. In the respondents with self-reported hypertension, higher utility index and VAS scores were found in those who were female, younger, married, employed, smoking, drinking, exercising regularly, absent from comorbidity, resided in the eastern developed region, had normal body mass index, higher levels of education, and income. Hypertension management programs were associated with higher utility index (β = 0.01) and VAS scores (β = 1.02). Overall, hypertension is associated with lower HRQoL. Higher socioeconomic status and participation in management programs for chronic conditions are independent predictors of higher HRQoL of hypertensive people. This study provides a national representative estimate on the HRQoL of hypertensive people in China, which can be used for calculating the burden of hypertension.
Combining Heart Rate Variability with Disease Severity Score Variables for Mortality Risk Stratification in Septic Patients Presenting at the Emergency Department
Authors: Pong Jeremy Zhenwen , Fook-Chong Stephanie , Koh Zhi Xiong , Samsudin Mas’uud Ibnu , Tagami Takashi , Chiew Calvin J. , Wong Ting Hway , Ho Andrew Fu Wah , Ong Marcus Eng Hock , Liu Nan
Published: May 2019

The emergency department (ED) serves as the first point of hospital contact for many septic patients, where risk-stratification would be invaluable. We devised a combination model incorporating demographic, clinical, and heart rate variability (HRV) parameters, alongside individual variables of the Sequential Organ Failure Assessment (SOFA), Acute Physiology and Chronic Health Evaluation II (APACHE II), and Mortality in Emergency Department Sepsis (MEDS) scores for mortality risk-stratification. ED patients fulfilling systemic inflammatory response syndrome criteria were recruited. National Early Warning Score (NEWS), Modified Early Warning Score (MEWS), quick SOFA (qSOFA), SOFA, APACHE II, and MEDS scores were calculated. For the prediction of 30-day in-hospital mortality, combination model performed with an area under the receiver operating characteristic curve of 0.91 (95% confidence interval (CI): 0.88–0.95), outperforming NEWS (0.70, 95% CI: 0.63–0.77), MEWS (0.61, 95% CI 0.53–0.69), qSOFA (0.70, 95% CI 0.63–0.77), SOFA (0.74, 95% CI: 0.67–0.80), APACHE II (0.76, 95% CI: 0.69–0.82), and MEDS scores (0.86, 95% CI: 0.81–0.90). The combination model had an optimal sensitivity and specificity of 91.4% (95% CI: 81.6–96.5%) and 77.9% (95% CI: 72.6–82.4%), respectively. A combination model incorporating clinical, HRV, and disease severity score variables showed superior predictive ability for the mortality risk-stratification of septic patients presenting at the ED.
Finasteride-Induced Inhibition of 5α-Reductase Type 2 Could Lead to Kidney Damage—Animal, Experimental Study
Authors: Baig Mirza Saim , Kolasa-Wołosiuk Agnieszka , Pilutin Anna , Safranow Krzysztof , Baranowska-Bosiacka Irena , Kabat-Koperska Joanna , Wiszniewska Barbara
Published: May 2019

In the pharmacological treatment of prostate cancer, benign prostatic hyperplasia and androgenetic alopecia finasteride is commonly used. This drug inhibits 5α-reductase type 2, which is why finasteride affects androgen homeostasis, since testosterone (T) cannot be reduced to dihydrotestosterone (DHT). As studies on sex-related renal injuries suggest a high probability of androgen-induced renal dysfunction, the aim of this study was to determine the potential harmful effects of finasteride on the kidneys of rats. The study was performed on sexually mature male Wistar rats given finasteride. Histological sections of the kidneys were used for immunohistochemical visualization of the androgen receptor (AR), junctional proteins (occluding (Occ); E-cad, N-cad, E-/N-cadherin; β-cat, β-catenin; connexin 43 (Cx43)), proliferating cell nuclear antigen (PCNA), IL-6, and lymphocyte markers (CD3 for T cell, CD19 for B cell). The TUNEL method was used for cell apoptosis identification, and picro sirius red staining was used to assess collagen fibers thickness. The levels of T, DHT and estradiol (E2) were determined in blood serum. It was shown that finasteride treatment affected steroid hormone homeostasis, altered the expression of AR and intracellular junction proteins, changed the ratio between cell apoptosis and proliferation, and caused lymphocyte infiltration and an increase of IL-6. The thickening of collagen fibers was observed as tubular fibrosis and glomerulosclerosis. Summarizing, finasteride-induced hormonal imbalance impaired the morphology (i.e., dysplastic glomeruli, swollen proximal convoluted tubules) and physiology (changed level of detected proteins/markers expression) of the kidneys. Therefore, it is suggested that patients with renal dysfunction or following renal transplantation, with androgen or antiandrogen supplementation, should be under special control and covered by extended diagnostics, because the adverse negative effect of DHT deficiency on the progression of kidney disease cannot be ignored.
Post-9/11 Peripheral Neuropathy Symptoms among World Trade Center-Exposed Firefighters and Emergency Medical Service Workers
Authors: Colbeth Hilary L. , Zeig-Owens Rachel , Webber Mayris P. , Goldfarb David G. , Schwartz Theresa M. , Hall Charles B. , Prezant David J.
Published: May 2019

Peripheral neuropathy can result from numerous conditions including metabolic disorders, inflammatory disease, or exposure to environmental or biological toxins. We analyzed questionnaire data from 9239 Fire Department of the City of New York (FDNY) World Trade Center (WTC)-exposed firefighters and emergency medical service workers (EMS) to evaluate the association between work at the WTC site and subsequent peripheral neuropathy symptoms using the validated Diabetic Neuropathy Symptom (DNS) score. We grouped the population into an “Indicated” group with conditions known to be associated with paresthesia (N = 2059) and a “Non-Indicated” group without conditions known to be associated (N = 7180). The level of WTC exposure was categorized by time of arrival to the WTC. Overall, 25% of workers aged 40 and older reported peripheral neuropathy symptoms: 30.6% in the Indicated and 23.8% in the Non-Indicated groups, respectively. Multivariable logistic models performed on the Non-Indicated group, and on the Non-Indicated in comparison with non-WTC exposed National Health and Nutrition Examination Survey (NHANES), found that the highest level of WTC-exposure was significantly associated with DNS positive outcomes, after controlling for potential confounders. In conclusion, this study suggests that symptoms of peripheral neuropathy and paresthesias are common and are associated with WTC-exposure intensity.
Parental Socialization and Development of Chinese Youths: A Multivariate and Comparative Approach
Authors: Yeung Jerf W. K. , Tsang Eileen Y. H. , Chen Hui-Fang
Published: May 2019

Parental socialization has been recently reported as a multifaceted concept, which includes parenting practices and family processes. Nevertheless, prior family research generally treated parental socialization tantamount to parenting behavior only and overlooked its different effects on multiple youth outcomes simultaneously, especially in the Chinese population. This study, with a sample of 223 Chinese parent-youth dyads (80.7% mothers; 55.6% male youths; meanage = 16.7 years), found that both authoritative parenting and positive family processes, as measured by a multi-informant approach, significantly predicted higher self-esteem, self-control, future orientation, other perspective taking and lower externalizing problem behavior of Chinese youths concomitantly. Furthermore, youth self-esteem was found to significantly mediate the effects of authoritative parenting and positive family processes on their self-control, future orientation, other perspective taking and externalizing problem behavior, and different facets of parental socialization significantly predicted the youth outcomes differentially. Results of this study highlight importance of considering the multifaceted nature of parental socialization and interrelations of youth development.
Asymmetric Bargaining Model for Water Resource Allocation over Transboundary Rivers
Authors: Qin Jianan , Fu Xiang , Peng Shaoming , Xu Yuni , Huang Jie , Huang Sha
Published: May 2019

Sustainable transboundary water governance is often challenged by conflicts between agents, which necessitates the design of cooperative and self-enforcing alternatives to facilitate equitable water distribution. The Nash bargaining approach, which originated from game theory, could offer a good mathematical framework to simulate strategic interactions among involved agents by considering individual rational benefits. Given that river-sharing problems often involve multiple self-interested agents, the asymmetric Nash bargaining solution (ANBS) could be used to describe agents’ powers, as determined by disparate social, economic, and political as well as military status, and ensure win–win strategies based on individual rationality. This paper proposed an asymmetric bargaining model by combining multi-criteria decision making, bankruptcy theory, and the ANBS for water distribution in the transboundary river context. The Euphrates River Basin (ERB) with three littoral states was used as a case study. Turkey has the highest bargaining power in ERB negotiation since it dominates in terms of economic strength, political influence, and military capacity, whereas in the two downstream countries these aspects are limited due to their internal political fragmentation and weaker military status. The water satisfaction percentages of Turkey, Syria, and Iraq under the best alternative are 96.30%, 84.23%, and 40.88%, respectively. The findings highlight the necessity for synthetically considering the agent’s disagreement utility and asymmetrical power when negotiating over water allocation.
Concentration of Selected Elements in the Infrapatellar Fat Pad of Patients with a History of Total Knee Arthroplasty
Authors: Ciosek Żaneta , Kosik-Bogacka Danuta , Łanocha-Arendarczyk Natalia , Kot Karolina , Karaczun Maciej , Ziętek Paweł , Kupnicka Patrycja , Szylińska Aleksandra , Rotter Iwona
Published: May 2019

In the period of long development, the human body adapted to specific concentrations of trace elements. Any changes in the trace element content manifesting in a deficiency or excess of metals in the human body may impair the functioning of the skeletal and articular system and of the organs, and may also predispose the body to the development of diseases, i.e., osteoporosis. Our study aimed to analyze the concentrations of calcium (Ca), magnesium (Mg), fluorides (F-), and lead (Pb) in the infrapatellar fat pad (Hoffa’s fat pad) of subjects who had undergone a total knee replacement (TKR) surgery. We also endeavored to establish how concentration levels of those elements are affected by selected biological and environmental factors. The studied group comprised 48 residents of Western Pomerania Province: 34 women (n = 34) aged 56–87 and 12 men (n = 12) aged 59–85. Concentration levels of Ca, Mg, and Pb were established using inductively coupled plasma-atomic emission spectrometry (ICP-AES). A Thermo Orion ion-selective electrode was applied for measuring F- concentration. Subjects aged 75–87 showed higher Mg concentration values than those aged 56–74. Big city residents and smokers were found to have higher infrapatellar fat pad Mg concentration than their non-smoking counterparts and small town dwellers. Of all the elements whose concentrations we analyzed in our studies, only magnesium was found to correlate with smoking, place of residence, and age. Our findings regarding the quantities of selected elements in the infrapatellar fat pad may be used for the interpretation and analysis of biological, morphological, and mechanical changes in the human body.
Spatial Effects of Technological Progress and Financial Support on China’s Provincial Carbon Emissions
Authors: Zhou Yingying , Xu Yaru , Liu Chuanzhe , Fang Zhuoqing , Guo Jiayi
Published: May 2019

The spatial autocorrelation analysis method was applied to panel data from the provinces of China (including autonomous regions and municipalities directly under the central government) for the period 2003 to 2016 in order to construct a spatial Durbin model of technological progress and financial support in relation to reductions in carbon emissions. The results show that China’s carbon intensity presents significant spatial spillover effects under different spatial weights, which indicates that the carbon intensity of a province is influenced not only by its own characteristics, but also by the carbon emission behaviors of geographically adjacent and economically similar provinces and regions. Financial structure, financial scale, and financial efficiency all have significant effects on carbon intensity within a province, while financial structure is also linked to carbon intensity in other regions, but financial scale has no significant spillover effect on carbon intensity in space. Areas with high financial efficiency can reduce their own carbon intensity as well as that of surrounding areas. The inter-regional spillover effect of technological progress on carbon intensity is stronger than the spillover effect, but there is a time lag.
Molecular Targets of Genistein and Its Related Flavonoids to Exert Anticancer Effects
Authors: Chae Hee-Sung , Xu Rong , Won Jae-Yeon , Chin Young-Won , Yim Hyungshin
Published: May 2019

Increased health awareness among the public has highlighted the health benefits of dietary supplements including flavonoids. As flavonoids target several critical factors to exert a variety of biological effects, studies to identify their target-specific effects have been conducted. Herein, we discuss the basic structures of flavonoids and their anticancer activities in relation to the specific biological targets acted upon by these flavonoids. Flavonoids target several signaling pathways involved in apoptosis, cell cycle arrest, mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K)/AKT kinase, and metastasis. Polo-like kinase 1 (PLK1) has been recognized as a valuable target in cancer treatment due to the prognostic implication of PLK1 in cancer patients and its clinical relevance between the overexpression of PLK1 and the reduced survival rates of several carcinoma patients. Recent studies suggest that several flavonoids, including genistein directly inhibit PLK1 inhibitory activity. Later, we focus on the anticancer effects of genistein through inhibition of PLK1.
The Kinase CIPK11 Functions as a Negative Regulator in Drought Stress Response in Arabidopsis
Authors: Ma Yanlin , Cao Jing , Chen Qiaoqiao , He Jiahan , Liu Zhibin , Wang Jianmei , Li Xufeng , Yang Yi
Published: May 2019

Drought is a major limiting factor for plant growth and crop productivity. Many Calcineurin B-like interacting protein kinases (CIPKs) play crucial roles in plant adaptation to environmental stresses. It is particularly essential to find the phosphorylation targets of CIPKs and to study the underlying molecular mechanisms. In this study, we demonstrate that CIPK11 acts as a novel component to modulate drought stress in plants. The overexpression of CIPK11 (CIPK11OE) in Arabidopsis resulted in the decreased tolerance of plant to drought stress. When compared to wild type plants, CIPK11OE plants exhibited higher leaf water loss and higher content of reactive oxygen species (ROS) after drought treatment. Additionally, a yeast two hybrid screening assay by using CIPK11 as a bait captures Di19-3, a Cys2/His2-type zinc-finger transcription factor that is involved in drought stress, as a new interactor of CIPK11. Biochemical analysis revealed that CIPK11 interacted with Di19-3 in vivo and it was capable of phosphorylating Di19-3 in vitro. Genetic studies revealed that the function of CIPK11 in regulating drought stress was dependent on Di19-3. The transcripts of stress responsive genes, such as RAB18, RD29A, RD29B, and DREB2A were down-regulated in the CIPK11OE plants. Whereas overexpression of CIPK11 in di19-3 mutant background, expression levels of those marker genes were not significantly altered. Taken together, our results demonstrate that CIPK11 partly mediates the drought stress response by regulating the transcription factor Di19-3.
Dysbiosis Disrupts Gut Immune Homeostasis and Promotes Gastric Diseases
Authors: Toor Devinder , Wsson Mishi Kaushal , Kumar Prashant , Karthikeyan G. , Kaushik Naveen Kumar , Goel Chhavi , Singh Sandhya , Kumar Anil , Prakash Hridayesh
Published: May 2019

Perturbation in the microbial population/colony index has harmful consequences on human health. Both biological and social factors influence the composition of the gut microbiota and also promote gastric diseases. Changes in the gut microbiota manifest in disease progression owing to epigenetic modification in the host, which in turn influences differentiation and function of immune cells adversely. Uncontrolled use of antibiotics, chemotherapeutic drugs, and any change in the diet pattern usually contribute to the changes in the colony index of sensitive strains known to release microbial content in the tissue micromilieu. Ligands released from dying microbes induce Toll-like receptor (TLR) mimicry, skew hypoxia, and cause sterile inflammation, which further contributes to the severity of inflammatory, autoimmune, and tumorous diseases. The major aim and scope of this review is both to discuss various modalities/interventions across the globe and to utilize microbiota-based therapeutic approaches for mitigating the disease burden.
Vascular Dysfunction Induced by Mercury Exposure
Authors: Takahashi Tetsuya , Shimohata Takayoshi
Published: May 2019

Methylmercury (MeHg) causes severe damage to the central nervous system, and there is increasing evidence of the association between MeHg exposure and vascular dysfunction, hemorrhage, and edema in the brain, but not in other organs of patients with acute MeHg intoxication. These observations suggest that MeHg possibly causes blood–brain barrier (BBB) damage. MeHg penetrates the BBB into the brain parenchyma via active transport systems, mainly the l-type amino acid transporter 1, on endothelial cell membranes. Recently, exposure to mercury has significantly increased. Numerous reports suggest that long-term low-level MeHg exposure can impair endothelial function and increase the risks of cardiovascular disease. The most widely reported mechanism of MeHg toxicity is oxidative stress and related pathways, such as neuroinflammation. BBB dysfunction has been suggested by both in vitro and in vivo models of MeHg intoxication. Therapy targeted at both maintaining the BBB and suppressing oxidative stress may represent a promising therapeutic strategy for MeHg intoxication. This paper reviews studies on the relationship between MeHg exposure and vascular dysfunction, with a special emphasis on the BBB.
Timing of Ureteric Stent Removal and Occurrence of Urological Complications after Kidney Transplantation: A Systematic Review and Meta-Analysis
Authors: Visser Isis J. , van der Staaij Jasper P. T. , Muthusamy Anand , Willicombe Michelle , Lafranca Jeffrey A. , Dor Frank J. M. F.
Published: May 2019

Implanting a ureteric stent during ureteroneocystostomy reduces the risk of leakage and ureteral stenosis after kidney transplantation (KTx), but it may also predispose to urinary tract infections (UTIs). The aim of this study is to determine the optimal timing for ureteric stent removal after KTx. Searches were performed in EMBASE, MEDLINE Ovid, Cochrane CENTRAL, Web of Science, and Google Scholar (until November 2017). For this systematic review, all aspects of the Cochrane Handbook for Interventional Systematic Reviews were followed and it was written based on the PRISMA-statement. Articles discussing JJ-stents (double-J stents) and their time of removal in relation to outcomes, UTIs, urinary leakage, ureteral stenosis or reintervention were included. One-thousand-and-forty-three articles were identified, of which fourteen articles (three randomised controlled trials, nine retrospective cohort studies, and two prospective cohort studies) were included (describing in total n = 3612 patients). Meta-analysis using random effect models showed a significant reduction of UTIs when stents were removed earlier than three weeks (OR 0.49, CI 95%, 0.33 to 0.75, p = 0.0009). Regarding incidence of urinary leakage, there was no significant difference between early (<3 weeks) and late stent removal (>3 weeks) (OR 0.60, CI 95%, 0.29 to 1.23, p = 0.16). Based on our results, earlier stent removal (<3 weeks) was associated with a decreased incidence of UTIs and did not show a higher incidence of urinary leakage compared to later removal (>3 weeks). We recommend that the routine removal of ureteric stents implanted during KTx should be performed around three weeks post-operatively.
Mapping the Sandy Beach Evolution Around Seaports at the Scale of the African Continent
Authors: de Boer Wiebe , Mao Yongjing , Hagenaars Gerben , de Vries Sierd , Slinger Jill , Vellinga Tiedo
Published: May 2019

In Africa, several new seaport developments are being considered. In sedimentary environments, such port developments can have adverse impacts on the evolution of adjacent coastlines. To learn from past port engineering practice, we created a unique database containing the coastline evolution and characteristics of 130 existing African seaports. Whereas the systematic mapping of coastal impacts was previously hampered by data availability, innovative automated satellite image processing techniques have enabled us to intercompare ports at an unprecedented continental scale. We found large geographical differences with respect to the beach evolution. The total detected changes in the beach area between 1984 and 2018 totaled 44 km2, of which ca. 23 km2 is accretion and ca. 21 km2 is erosion. The top 10% “hotspot” ports account for more than 65% of these changes. These hotspots exhibit common characteristics, namely: they are located on open coastlines, have large alongshore sediment transport potential, and have large cross-shore breakwaters. Although these driving characteristics are well established in coastal engineering theory, our results indicate that the beaches adjacent to the existing seaports have been and remain seriously affected by these drivers. Our results can be used to inform beach maintenance strategies for existing seaports and to support planners and engineers to minimize long-term coastal impacts of port expansions and new port developments in Africa in the future.
Infrared Brazed Joints of Ti50Ni50 Shape Memory Alloy and Ti-15-3 Alloy Using Two Ag-Based Fillers
Authors: Lin Chieh , Shiue Ren-Kae , Wu Shyi-Kaan , Yang Tsung-En
Published: May 2019

The wettability, microstructures, and bonding strength of infrared brazing Ti-15-3 and Ti50Ni50 shape memory alloy using 72Ag-28Cu (wt.%) and 68.8Ag-26.7Cu-4.5Ti (wt.%) filler metals have been investigated. Only Ticusil® active braze readily wets both Ti50Ni50 and Ti-15-3 substrates. Wetting of eutectic 72Ag-28Cu melt on Ti50Ni50 base metal is greatly ameliorated by adding 4.5 wt.% Ti into the alloy. The brazed Ti-15-3/BAg-8/Ti50Ni50 joint consists of Cu-Ti intermetallics in the Ag-rich matrix. The formation of interfacial Cu(Ti,V) and (CuxNi1−x)2Ti intermetallics next to Ti-15-3 and Ti50Ni50 substrates, respectively, is attributed to the wetting of both substrates. The brazed Ti-15-3/Ticusil®/Ti50Ni50 joint shows a vigorous reaction, which results in the formation of a large amount of Ti2Ni intermetallics in the joint. The maximum joint strengths using BAg-8 and Ticusil® filler metals are 197 MPa and 230 MPa, respectively.
Nano-Carriers Based on pH-Sensitive Star-Shaped Copolymers for Drug-Controlled Release
Authors: Jiang Wenzhao , Guo Jianwei , Wen Weiqiu , Jia Yong-Guang , Liu Sa
Published: May 2019

Polymeric nano-carriers are considered as promising tools in biomedical applications due to multiple attractive characteristics including their low toxicity, high loading capacity, controlled drug release capabilities, and highly tunable chemical properties. Here, a series of pH-sensitive star-shaped copolymers, Ad-P[(EMA-co-MAA)-b-PPEGMA]4, was prepared via electron transfer atom radical polymerization (ARGETE ATRP) and selective hydrolysis. These star-shaped copolymers can be self-assembled into micelles (Dh = 150–160 nm) and their critical micelle concentrations (CMC) were estimated to be 3.9–5.0 mg/L. The pH-sensitiveness of the micelles was evidenced by transmission electron microscopy (TEM) and dynamic light scattering (DLS). The maximal paclitaxel (PTX) loading efficiency (DLC) and entrapment efficiency (EE) were 18.9% and 36%, respectively. In vitro release studies revealed that about 19% of the PTX released at an acidic condition of pH 1.2 over 70 h, whereas more than 70% was released within the same time interval at pH 6.8. In vitro cytotoxicity suggested that the low cytotoxicity of the blank micelles, while the PTX-loaded micelles providing the cytotoxicity close to that of free PTX. These results indicated that this novel pH-sensitive nano-carriers have great potential applications for oral drug-controlled release.
Enhancing Photovoltaic Performance of Plasmonic Silicon Solar Cells with ITO Nanoparticles Dispersed in SiO2 Anti-Reflective Layer
Authors: Ho Wen-Jeng , Chen Guan-Yu , Liu Jheng-Jie
Published: May 2019

In this study, we sought to enhance the photovoltaic performance of silicon solar cells by coating them (via the spin-on film technique) with a layer of SiO2 containing plasmonic indium-tin-oxide nanoparticles (ITO-NPs) of various concentrations. We demonstrated that the surface plasmon resonance absorption, surface morphology, and transmittance of the ITO-NPs dispersed in SiO2 layer at various concentrations (1–7 wt%). We also assessed the plasmonic scattering effects of ITO-NPs within a layer of SiO2 with and without a sub-layer of ITO in terms of optical reflectance, external quantum efficiency, and photovoltaic current-voltage under air mass (AM) 1.5G solar simulation. Compared to an uncoated reference silicon solar cell, applying a layer of SiO2 containing 3 wt% ITO-NPs improved efficiency by 17.90%, whereas applying the same layer over a sub-layer of ITO improved efficiency by 33.27%, due to the combined effects of anti-reflection and plasmonic scattering.
Integral Involving Bessel Functions Arising in Propagation Phenomena
Authors: Ratis Yu. L. , Fernández de Córdoba P. , Isidro J. M. , Jaime R.
Published: May 2019

An new integral identity involving the product of two modified Bessel functions K 0 and K 1 , previously unreported, is presented and proved.
Numerical Method for Solving the Robust Continuous-Time Linear Programming Problems
Authors: Wu Hsien-Chung
Published: May 2019

A robust continuous-time linear programming problem is formulated and solved numerically in this paper. The data occurring in the continuous-time linear programming problem are assumed to be uncertain. In this paper, the uncertainty is treated by following the concept of robust optimization, which has been extensively studied recently. We introduce the robust counterpart of the continuous-time linear programming problem. In order to solve this robust counterpart, a discretization problem is formulated and solved to obtain the ϵ -optimal solution. The important contribution of this paper is to locate the error bound between the optimal solution and ϵ -optimal solution.
Unique Associations between Insulin-Like Growth Factor Binding Protein-1, Insulin-Like Growth Factor-1 and T Cell Immunoglobulin Mucin 3 in Successful Twin Pregnancies Conceived with Donor Oocytes
Authors: Sisti Giovanni , Di Tommaso Mariarosaria , Paccosi Sara , Parenti Astrid , Seravalli Viola , Cuzzola Roberta , Witkin Steven S.
Published: May 2019

Background and Objectives: To investigate if pregnancies conceived using an oocyte donor necessitate an alteration in immune regulation, we compared concentrations of insulin-like growth factor binding protein (IGFBP)-1, insulin-like growth factor (IGF)-1 and T cell immunoglobulin mucin-3 (Tim-3) in women with ongoing successful twin pregnancies conceived spontaneously, using assisted reproductive technologies that utilized homologous oocytes or with donor oocytes. Differences in levels of these immune modulatory proteins may be magnified and easier to detect in twin as compared to singleton pregnancies. Methods: In this prospective study IGFBP-1 and IGF-1 were measured in sera and Tim-3 in lysates of peripheral blood mononuclear cells (PBMCs) by ELISA. Results: Median IGFBP-1 levels were lower in women with donor oocytes (41.4 ng/ml) as compared to those with a spontaneous conception (51.2 ng/mL) or who conceived with various assisted reproduction protocols using homologous oocytes (52.4 ng/mL) (p < 0.001). IGF-1 and Tim-3 levels were comparable in each group. The IGFBP-1 level was inversely correlated to the IGF-1 concentration only in women with donor oocytes (p = 0.032). IGFBP-1 and Tim-3 levels were similarly negatively correlated in the donor oocyte group (p = 0. 012). Women in the assisted reproduction group who conceived following intracytoplasmic sperm injection were the only other group in which IGFBP-1 and Tim-3 were negatively correlated (p = 0.018). Conclusions: Down-regulation of IGFBP-1 production in pregnancies conceived with donor oocytes may reduce the extent of pro-inflammatory immunity and contribute to successful outcome in totally allogeneic pregnancies.
DPP-4 as a Possible Biomarker of Inflammation Before Abdominal Surgery for Chronic Pathology: Our Experience with Elective Cholecystectomy
Authors: Valencia-Sánchez Liliana , Almendra-Pegueros Rafael , Diaz R-Valdez Luis Jose , Esmer-Sánchez David , Medina Úrsula , Gordillo-Moscoso Antonio
Published: May 2019

Background and objectives: Dipeptidyl-Peptidase 4 (DPP-4) is a protein expressed in numerous cells and tissues. Recently it has shown its involvement as a catalyst in the inflammatory response in various pulmonary, autoimmune, intestinal and other pathologies. The objective of this study was to compare the preoperative serum levels of DPP-4 in patients with and without surgical finding of perivesicular inflammation. Materials and methods: a cross-sectional analytical study nested in a prospective cohort, including patients scheduled for elective cholecystectomy, without surgical complications, that were 18–70 years of age, with low cardiovascular risk, without a history of peritonitis, pancreatitis, or jaundice and underwent ERCP protocol, type 2 diabetes mellitus, acute inflammatory (Protein C Reactive < 3 mg/L, leucocytes < 10 1000/mm3), neoplastic, nephrologic or liver disease, the use of anti-inflammatory drugs, steroids and/or antibiotics, the use of pacemakers or metallic implants and without major amputations and whom agreed to participate by providing their informed consent. Ethical and Research register: 45–16. Prior to surgery we compiled anthropometric data and a blood sample to determine the serum levels of DPP-4. The presence of perivesicular inflammation was determined in the surgery. The data was analyzed using the statistical program Rstudio. Results: High BMI values were observed (27.8 ± 6.4); waist circumference (94.7 ± 15.1) and percentage of fat mass (34.7 ± 11.7), showing a cumulative frequency of 65.9% for overweight/obesity. In 27.3% of the interventions, intraoperative perivesicular inflammation findings were reported. The serum levels of DPP-4 were lower in the group of patients with perivesicular inflammation (3947.6 ± 1659.5 vs. 3053.2 ± 1469.6, LC95% of the difference: 160.4–1628.3), being statistically significant (p = 0.018). Conclusions: In the subacute or chronic phases of cholecystitis, there appears to be a constant consumption of DPP-4, which would modulate a better immune response that could be related to the reduction of postoperative complications, so the use of Serum levels of DPP-4 as an early biomarker could improve the diagnostic accuracy of this pathology and the surgical approach.
Correction: Shen, X. et al. Research on the Disc Sensitive Structure of a Micro Optoelectromechanical System (MOEMS) Resonator Gyroscope. Micromachines, 2019, 10, 264
Authors: Shen Xiang , Zhao Liye , Xia Dunzhu
Published: May 2019

In the published paper [...]
Wettability Manipulation by Interface-Localized Liquid Dielectrophoresis: Fundamentals and Applications
Authors: Barman Jitesh , Shao Wan , Tang Biao , Yuan Dong , Groenewold Jan , Zhou Guofu
Published: May 2019

Electric field-based smart wetting manipulation is one of the extensively used techniques in modern surface science and engineering, especially in microfluidics and optofluidics applications. Liquid dielectrophoresis (LDEP) is a technique involving the manipulation of dielectric liquid motion via the polarization effect using a non-homogeneous electric field. The LDEP technique was mainly dedicated to the actuation of dielectric and aqueous liquids in microfluidics systems. Recently, a new concept called dielectrowetting was demonstrated by which the wettability of a dielectric liquid droplet can be reversibly manipulated via a highly localized LDEP force at the three-phase contact line of the droplet. Although dielectrowetting is principally very different from electrowetting on dielectrics (EWOD), it has the capability to spread a dielectric droplet into a thin liquid film with the application of sufficiently high voltage, overcoming the contact-angle saturation encountered in EWOD. The strength of dielectrowetting depends on the ratio of the penetration depth of the electric field inside the dielectric liquid and the difference between the dielectric constants of the liquid and its ambient medium. Since the introduction of the dielectrowetting technique, significant progress in the field encompassing various real-life applications was demonstrated in recent decades. In this paper, we review and discuss the governing forces and basic principles of LDEP, the mechanism of interface localization of LDEP for dielectrowetting, related phenomenon, and their recent applications, with an outlook on the future research.
An Unexpected Iron (II)-Based Homogeneous Catalytic System for Highly Efficient CO2-to-CO Conversion under Visible-Light Irradiation
Authors: Fu Zi-Cheng , Mi Cheng , Sun Yan , Yang Zhi , Xu Quan-Qing , Fu Wen-Fu
Published: May 2019

We present two as-synthesized Fe(II)-based molecular catalysts with 1,10-phenanthroline (phen) ligands; Fe(phen)3Cl2 (1) and [Fe(phen)2(CH3CH2OH)Cl]Cl (2), and their robust catalytic properties for the conversion of CO2 to CO in DMF/TEOA (DMF = N,N’-dimethylformamide; TEOA = triethanolamine) solution containing Ru(bpy)32+ and BIH (1,3-dimethyl-2-phenyl-2,3- dihydro-1H-benzo-[d]-imidazole). High turnover numbers (TONs) of 19,376 were achieved with turnover frequencies (TOFs) of 3.07 s−1 for complex 1 (1.5 × 10−7 M). A quantum efficiency of 0.38% was observed after 5 h irradiated by 450 nm monochromatic light. The generation rate of CO2 and H2 were tuned by optimizing the experimental conditions, resulting in a high CO selectivity of 90%. The remarkable contribution of the photosensitizer to the total TONCO was found being 19.2% (as shown by tests under similar conditions without catalysts) when BIH was employed as a sacrificial electron donor. The product selectivity in complex 2 reached 95%, and the corresponding TONCO and TOFCO were 33,167 and 4.61 s−1 in the same concentration with complex 1 used as catalyst; respectively. This work provides guidance for future designs of simple, highly efficient and selective molecular catalytic systems that facilitate carbon-neutral solar-to-fuel conversion processes
Why Is Very High Cholesterol Content Beneficial for the Eye Lens but Negative for Other Organs?
Authors: Widomska Justyna , Subczynski Witold K.
Published: May 2019

The plasma membranes of the human lens fiber cell are overloaded with cholesterol that not only saturates the phospholipid bilayer of these membranes but also leads to the formation of pure cholesterol bilayer domains. Cholesterol level increases with age, and for older persons, it exceeds the cholesterol solubility threshold, leading to the formation of cholesterol crystals. All these changes occur in the normal lens without too much compromise to lens transparency. If the cholesterol content in the cell membranes of other organs increases to extent where cholesterol crystals forma, a pathological condition begins. In arterial cells, minute cholesterol crystals activate inflammasomes, induce inflammation, and cause atherosclerosis development. In this review, we will indicate possible factors that distinguish between beneficial and negative cholesterol action, limiting cholesterol actions to those performed through cholesterol in cell membranes and by cholesterol crystals.
Can Serum Iron Concentrations in Early Healthy Pregnancy Be Risk Marker of Pregnancy-Induced Hypertension?
Authors: Lewandowska Małgorzata , Sajdak Stefan , Lubiński Jan
Published: May 2019

The aim of this study was to assess the relationship between serum iron concentrations in early healthy pregnancy and the risk of pregnancy-induced hypertension. The data comes from our prospective cohort study in which we recruited healthy women in week 10–14 of single pregnancy. We examined a study group (n = 121) consisting of women subsequently developing pregnancy-induced hypertension and a control group (n = 363) of matched women remaining normotensive. We measured iron concentrations in the serum collected in 10–14 gestational week, using the ICP-MS technique (mass spectrometry with inductively coupled plasma). The odds ratios of the disease (95% confidence intervals) for iron concentrations were assessed in multivariate logistic regression. We found that the mean microelement concentration was lower in the case group compared to normotensive controls (p = 0.011). Women in the lowest quartile of iron (≤801.20 µg/L) had a 2.19-fold increase in pregnancy-induced hypertension risk compared with women in the highest quartile (>1211.75 µg/L) (odds ratio (OR) = 2.19; 95% CI: 1.24–3.88; p = 0.007). This result was sustained after adjusted for all the accepted confounders. Women in the higher Q2 quartile (801.20–982.33 µg/L) had a 17% lower risk, compared with those in the highest quartile (OR = 0.83; 95% CI: 0.65–2.32; p = 0.519).
Anomaly-Induced Transport Phenomena from Imaginary-Time Formalism
Authors: Hongo Masaru , Hidaka Yoshimasa
Published: May 2019

A derivation of anomaly-induced transport phenomena—the chiral magnetic/vortical effect—is revisited based on the imaginary-time formalism of quantum field theory. Considering the simplest anomalous system composed of a single Weyl fermion, we provide two derivations: perturbative (one-loop) evaluation of the anomalous transport coefficient, and the anomaly matching for the local thermodynamic functional.
Debiasing in a Minute or Less, or Too Good to Be True? The Effect of Micro-Interventions on Decision-Making Quality
Authors: Kovic Marko
Published: May 2019

In this study, the effects of a novel debiasing micro-intervention (an intervention that requires no training or instructions) are tested in three experiments. The intervention is epistemologically informed and consists of two questions that prompt the quantification of degrees of a belief (“How certain am I?”) and the justification of a belief (“Why?”). In all three experiments, this intervention was ineffective. Unexpectedly, however, when the micro-intervention consisted only of the justification question (“Why?”), there was a small, but noticeable positive effect in two experiments. Overall, even though the hypothesized effects were not observable, a justification prompt might be a potentially effective micro-intervention that should be explored in future research.
Portable Biogas Digesters for Domestic Use in Jordanian Villages
Authors: Alkhalidi Ammar , Khawaja Mohamad K. , Amer Khaled A. , Nawafleh Audai S. , Al-Safadi Mohammad A.
Published: May 2019

Essential energy needs are not always met in poor and rural areas of developing counties; therefore, natural energy sources are necessary to mitigate this problem. Rural areas inhabitants utilize methane as a replacement for cooking gas to reduce their gas bill. Methane gas can be produced from a biogas digester; however, operating a large digester in a densely populated village in Jordan can be challenging due to inefficient village waste management systems. On the other hand, using a small-scale portable biogas digester to generate biogas could overcome these problems. In this work, three biogas digester feedstocks for a small portable biogas digester from natural sources available in Jordanian villages such as human and animal waste were designed and evaluated. The three feedstocks are food waste, human waste, and a mixture of human and food waste. The parameters tested were the digester size and the biogas production. The results showed that the best digester for portable application was that which digested a mixture of human and food waste; for a five-member family, this type of digester provided 115% of the family’s cooking gas requirements with a digester volume of 0.54 m3. This design, while applicable for a typical rural Jordanian family, can also be utilized globally.
Simulation of the Operation of a Spark Ignition Engine Fueled with Various Biofuels and Its Contribution to Technology Management
Authors: Tucki Karol , Mruk Remigiusz , Orynycz Olga , Wasiak Andrzej , Botwińska Katarzyna , Gola Arkadiusz
Published: May 2019

Economic progress, development of transport, production of new cars, production of more and more energy, and the combustion of fossil fuels are causing huge changes that are currently occurring in the environment. Ecological problems of the contemporary economy combined with perspectives of resources exhaustion, as well as the need to follow sustainable rules of living, require the search for new fuels. Fuels which can assure their availability and good environmental performance are needed for maintaining sustainable transportation. Knowledge about the behavior of various fuels is necessary for realistic methods of technology management in transportation means and the fuel industry. This paper describes biofuels that can be an addition to petrol or can exist as standalone fuels. A simulation was carried out on an urban vehicle and the tested fuels were petrol 95, ethanol, methanol, and dimethyl ether. For the selected engine a simulation corresponding to that of the New European Driving Cycle (NEDC) test was created using the Scilab package. Based on this simulation, values of carbon dioxide and water vapor emission were determined. The fuel demand for each fuel mixture and the amount of air for the fuels used were also calculated (and verified on the basis of laboratory tests). It was demonstrated that addition of biofuel decreases emission of carbon dioxide, simultaneously increasing emission of water vapor. Biofuel additive also caused an increase in fuel consumption. Unfortunately, in the New European Driving Cycle test being investigated, carbon dioxide emissions in all cases exceeded the permissible level of 130 g CO2/km, which is bad news in the context of the further tightening of norms and standards. The simulation tests confirmed that when using the start/stop system and applying specific additives, the carbon dioxide emission decreases and the consumption of mixtures with the activated start/stop system is smaller. The analyzed problems and results of this analysis become more important in light of the Worldwide Harmonized Light Duty Vehicles Test Procedure (WLTP) standard, which became binding from September 2018 and applies to the sale of cars that had been approved prior (in accordance with the New European Driving Cycle standard). Although the NEDC standard appears obsolete the computer model simulating this type of test will be necessary in many cases. It is, however, needed and possible to develop a similar simulation procedure for WLTP tests.