bluuebunny/crossref_metadata_2025 huggingface dataset:
Signatures of Gait Movement Variability in CKD Patients Scheduled for Hemodialysis Indicate Pathological Performance Before and After Hemodialysis: A Prospective, Observational Study
Authors: Zemp Damiano D. , Giannini Olivier , Quadri Pierluigi , Rabuffetti Marco , Tettamanti Mauro , de Bruin Eling D.
Published: July 2021

Background: The frailty status of hemodialysis patients is well-known, but the role of the therapy in the frailty process is not yet clear. Nowadays gait analysis in nephrology is neglected, although gait performance is known to be related to frailty and kidney function. We hypothesized that gait quality and physical activity level is already affected before, and does not change because of the start of hemodialysis.

Methods: Fourteen patients (72.3 ± 5.7 years old) in a pre-dialysis program underwent an instrumental gait analysis and their physical activity was monitored for a week. This protocol was repeated 3, 6, 12, and 24 months after the first hemodialysis session.

Results: At baseline, our sample showed a conservative gait with pathologic gait variability, high dual-task cost, and a sedentary lifestyle. No statistically significant change was found in any parameter in the analyzed period, but there was a tendency toward an improvement of gait quality and physical activity in the first year of treatment, and a decline in the second year.

Conclusion: Elderly patients in the pre-dialysis stage show a conservative gait, however variability was in a pathological range and did not change post-hemodialysis. This hints toward changes in the central nervous system due to the kidney disease. This finding suggests the importance of gait analysis in the early stages of renal disease in the diagnosis of changes in the nervous system due to kidney failure that affect gait. Early detection of these changes would potentially allow a prevention program tailored to this population to be developed.
The miR-130a-3p/TGF-βRII Axis Participates in Inhibiting the Differentiation of Fibroblasts Induced by TGF-β1
Authors: Liu Yanhong , Ding Yan , Hou Yapeng , Yu Tong , Nie Hongguang , Cui Yong
Published: July 2021

Pulmonary fibrosis (PF) is a chronic progressive interstitial lung disease that has a poor prognosis. Abnormal activation of transforming growth factor-β1 (TGF-β1) plays a crucial role in fibroblast differentiation. Mesenchymal stem cells (MSCs) are currently being considered for the treatment of PF, but the regulatory mechanisms are poorly understood. We co-cultured bone marrow-derived MSCs and mouse lung fibroblasts (MLg) in the presence of TGF-β1, and studied the protein/mRNA expression of fibrosis markers and related signaling pathways. The effects of miR-130a-3p and TGF-β receptor II (TGF-βRII) on the differentiation of MLg induced by TGF-β1 were studied using immunofluorescence assay, Western blot, and quantitative real-time PCR techniques, respectively. Our results showed that MSCs reversed the overexpression of fibrosis markers and TGF-β1/Smad signaling pathway proteins and mRNAs after TGF-β1 treatment and increased the level of miR-130a-3p. TGF-βRII was identified as a target of miR-130a-3p and was evaluated by dual-luciferase reporter assay. The miR-130a-3p/TGF-βRII axis could suppress the differentiation of lung fibroblasts via the TGF-β1/Smad signaling pathway, thereby reducing the process of PF.
Knowledge, Attitude, and Practice Regarding COVID-19 Among Healthcare Workers in Primary Healthcare Centers in Dubai: A Cross-Sectional Survey, 2020
Authors: Albahri Abdulaziz Hussain , Alnaqbi Shatha Ahmed , Alnaqbi Shahad Ahmed , Alshaali Asma Obaid , Shahdoor Shaikha Mohammad
Published: July 2021

Introduction: The coronavirus disease 2019 (COVID-19) pandemic continues to challenge healthcare services worldwide. Healthcare workers (HCWs) are key to the continued effort to overcome the pandemic. This study aims to evaluate the knowledge, attitude, and practices of HCWs toward COVID-19 in primary health centers in Dubai.

Methods: This cross-sectional study was conducted at four primary health centers in Dubai, including two fever clinics, from July 5th to July 11th, 2020. A self-administered online questionnaire was distributed to nurses and physicians working in these centers, which evaluated their knowledge, attitude, and practices regarding COVID-19 and their associations with the participants' demographic factors. A total score of 80% and above constituted a level of sufficiency in each section. Additionally, Mann-Whitney U test and multivariable logistic regression were used to analyze the variables.

Results: A total of 176 HCWs completed the questionnaire, with a 91.2% (176/193) response rate. They were predominantly female (158/176, 90.0%), nurses (128/176, 72.7%), and non-Emiratis (150/176, 85.2%). While official health organizations were the primary source of information for 91.5% (161/176) of participants, only 38.1% (67/176) reported using scientific journals as one of their sources. Overall, 57.4% (101/176) of participants had a sufficient overall level of knowledge. Moreover, knowledge regarding signs, symptoms, and at-risk groups was generally satisfactory. However, knowledge about the virus, testing, transmission, and the isolation of contacts with positive cases was identified correctly by less than two-thirds of the participants. Half of the participants (89/176, 50.6%) expressed their concern about personally acquiring the infection, 112/176 (63.6%) worried about their relatives acquiring it, and 72/176 (40.9%) expressed some hesitancy to take the COVID-19 vaccine once available. Overall, only 58/176 (33.0%) HCWs had a sufficient overall positive attitude score. Nurses, compared to physicians, and non-Emiratis compared to Emiratis' HCWs, had statistically higher mean scores for attitude (U = 2,212, p < 0.01; and U = 1164.5, p < 0.01, respectively). The majority of participants (156/176, 88.6%) reported acceptable infection control practices.

Conclusion: Given the gaps identified in the knowledge and attitude, we recommend further training to improve the skills of primary HCWs, with encouragement to practice evidence-based medicine. Additionally, further exploration regarding vaccine hesitancy is warranted.
Early vs. Late Tracheostomy in Patients with Traumatic Brain Injury: Systematic Review and Meta-Analysis
Authors: Marra Annachiara , Vargas Maria , Buonanno Pasquale , Iacovazzo Carmine , Coviello Antonio , Servillo Giuseppe
Published: July 2021

Introduction. Tracheostomy can help weaning in long-term ventilated patients, reducing the duration of mechanical ventilation and intensive care unit length of stay, and decreasing complications from prolonged tracheal intubation. In traumatic brain injury (TBI), ideal timing for tracheostomy is still debated. We performed a systematic review and meta-analysis to evaluate the effects of timing (early vs. late) of tracheostomy on mortality and incidence of VAP in traumatic brain-injured patients. Methods. This study was conducted in conformity with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. We performed a search in PubMed, using an association between heading terms: early, tracheostomy, TBI, prognosis, recovery, impact, mortality, morbidity, and brain trauma OR brain injury. Two reviewers independently assessed the methodological quality of eligible studies using the Newcastle–Ottawa Scale (NOS). Comparative analyses were made among Early Tracheostomy (ET) and late tracheostomy (LT) groups. Our primary outcome was the odds ratio of mortality and incidence of VAP between the ET and LT groups in acute brain injury patients. Secondary outcomes included the standardized mean difference (MD) of the duration of mechanical ventilation, ICU length of stay (LOS), and hospital LOS. Results. We included two randomized controlled trials, three observational trials, one cross-sectional study, and three retrospective cohort studies. The total number of participants in the ET group was 2509, while in the LT group it was 2597. Early tracheostomy reduced risk for incidence of pneumonia, ICU length of stay, hospital length of stay and duration of mechanical ventilation, but not mortality. Conclusions. In TBI patients, early tracheostomy compared with late tracheostomy might reduce risk for VAP, ICU and hospital LOS, and duration of mechanical ventilation, but increase the risk of mortality.
A Dark Matter WIMP That Can Be Detected and Definitively Identified with Currently Planned Experiments
Authors: LaFontaine Caden , Tallman Bailey , Ellis Spencer , Croteau Trevor , Torres Brandon , Hernandez Sabrina , Guerrero Diego Cristancho , Jaksik Jessica , Lubanski Drue , Allen Roland
Published: July 2021

A recently proposed dark matter WIMP (weakly interacting massive particle) has only second-order couplings to gauge bosons and itself. As a result, it has small annihilation, scattering, and creation cross-sections, and is consequently consistent with all current experiments and the observed abundance of dark matter. These cross-sections are, however, still sufficiently large to enable detection in experiments that are planned for the near future, and definitive identification in experiments proposed on a longer time scale. The (multi-channel) cross-section for annihilation is consistent with thermal production and freeze-out in the early universe, and with current evidence for dark matter annihilation in analyses of the observations of gamma rays by Fermi-LAT and antiprotons by AMS-02, as well as the constraints from Planck and Fermi-LAT. The cross-section for direct detection via collision with xenon nuclei is estimated to be slightly below 10−47 cm2, which should be attainable by LZ and Xenon nT and well within the reach of Darwin. The cross-section for collider detection via vector boson fusion is estimated to be ∼1 fb, and may be ultimately attainable by the high-luminosity LHC; definitive collider identification will probably require the more powerful facilities now being proposed.
Modern technologies for identification of irrationally used and unused agricultural lands
Authors: Khabarova I.A. , Khabarov D.A.
Published: July 2021

In this article, the authors consider and analyze modern technologies for identifying irrational agricultural land, as well as the goal, objectives and requirements of land management in farms with significant amount of unused land.
The actual problems of cadastral system used for evaluation of agricultural land
Authors: Vyrodova Yu.N.
Published: July 2021

The article is about the formation of a new system of state cadastral evaluation of real estate after the coming into force the Federal Law "State Cadastral Evaluation". An analysis of the results of the first round (2018-2019) of the state cadastral evaluation carried out according to the new rules is presented in the paper by example of agricultural lands in the Central Federal District of Russia. The author proposed the scheme of the new cadastral evaluation system.
The symbiosis of “old” and “new” architecture – historical areas in modern cities
Authors: Nikiforova M.M.
Published: July 2021

The article deals with the most important problem of modern cities - the combination of the "new architecture" with the historically established quarters. This problem is caused by the emergence of innovative trends in architecture, which are formed under the influence of aesthetic, cultural, financial trends, as well as technological progress.

English version on pp. 239-246 is available at URL: https://panor.ru/articles/symbiosis-of-the-old-and-new-architecture-in-the-context-of-the-historic-urban-landscape-of-modern-cities/64067.html
On the flood paradigm of aqua-geological arrangement of the future rural architecture
Authors: Limonad M.Yu.
Published: July 2021

High waters systematically flood large areas and villages with their agricultural lands. People, livestock and crops perish on a huge scale. This situation should be accepted as a living condition, not an emergency. For this we need to radically reconstruct the buildings and architectural landscapes so that the floods stop being destructive. A variant of floating villages and their buildings, structures, and roads based on pontoon-pile systems and the creation of modular pontoon parks is proposed in this paper. The scale of the phenomenon requires the introduction of an appropriate national project.
Morphological diversity and differentiation of Asian populations of pink salmon Oncorhynchus gorbuscha (Walbaum) of even generations
Authors: Pustovoit Sergei Pavlovich
Published: July 2021

A morphological study of three Asian populations of pink salmon of the Ola, Bolshaya and Zhupanov rivers of adjacent even generations was carried out. For a quantitative description of the external appearance of pink salmon, a scheme of 17 measurements proposed by M.K. Glubokovsky [3] was used. On average, lower values of morphological diversity are characteristic of head measurements and fin heights, while indicators of body length and height have high indicators of morphological diversity. The hierarchical method of decomposition of morphological diversity makes it possible to find out the proportions of intrapopulation and interpopulation variability included in the total value of morphological diversity of each measurement. For females, the shares of morphological diversity averaged over all dimensions are as follows: sample — 48%, intra-annual — 19% and interpopulation — 33% share In males sample — 47%, intra-annual — 17% and interpopulation — 36% share. Thus, almost half of the total value of morphological diversity is determined by differences in morphological measurements between individuals within the sample, interpopulation differences make up one third of the total value, and the interannual share in the indicator of morphological differences is quite small. The rather high interpopulation proportion of morphological diversity indicates the possibility of using morphological measurements to distinguish populations from different parts of the range.
Coastal complex for growing fish planting material for stocking high-eftrophic reservoirs (on the example of the Veselovsky reservoir on the Western Manych River)
Authors: Shkura Viktor Nikolaevich , Shevchenko Alexey Viktorovich
Published: July 2021

The purpose of the study is to substantiate the creation and use of drivedriven fish-breeding and reclamation complexes that provide fish-breeding development and biological reclamation of eutrophic water bodies (reservoirs and lakes). The need to create drive-storage fish-breeding and reclamation complexes is determined by the need to involve eutrophied inland water bodies in the fisheries turnover and conduct environmental improvement. One of the typical arid natural-climatic zones is the Veselovsky reservoir on the Western Manych River, the survey of which established the need to clean it from excess vegetation. The measures carried out on the reservoir for the introduction of herbivorous fish do not give results and do not lead to the expected reclamation effect. The main disadvantages of the applied technologies of fish-breeding activities at the reservoir are the use of fish-planting material that is not adapted to the conditions of the stocked water body, as well as a number of technological disadvantages of various processes. To eliminate them, it is proposed to organize the Veselovsky fish-breeding and reclamation complex, which includes a fish hatchery located directly next to it, providing the cultivation of fish-planting material adapted to the conditions of the stocked reservoir using non-contact technology of cultivation and stocking with technical means, and carrying out acclimatization measures. The structure of the fish hatchery provides for the construction of a cascade of outgrowth pools with regulated conditions of the aquatic environment and food regime. The different-height arrangement of fish-breeding pools on the slope section allows for non-contact intra-complex movement of fish and the release of fish-planting material into the acclimatization bay of the stocked reservoir. The maintenance system provides for the gradual rearing of young fish in fish-breeding pools with the most close to the conditions of the stocked reservoir physical and chemical conditions of the habitat and a different ratio in the diet of hydrobionts of artificial and natural food.
Combining accounting practices to create an effective cost management system in the inter-organizational relationships of agro-entities
Authors: Khoruzhy Lyudmila Ivanovna , Katkov Yury Nikolaevich , Romanova Anastasiya Alekseevna
Published: July 2021

In the article, based on the theoretical analysis and study of accounting practices, a set of elements was formed for their use in the system of managing the costs of inter-organizational interaction of partners. The peculiarities of the combined system of calculation of the cost of agricultural products within the framework of inter-organizational cooperation, the existing accounting practices are described. Advantages of introduction and use of inter-organizational accounting and cost calculation system for efficient management of costs of inter-organizational cooperation of agro-entities have been identified. A system for managing the costs of inter-organizational cooperation in agro-industrial complex organizations has been developed and described. Possible problem areas are identified when introducing these calculation systems into the practical activities of agro-formations.
METHODS FOR INERTIA–FREE CONTROL OF NODE PROPERTIES VEHICLE CREW
Authors: DOROFEEV O.V. , VOROBYEV V.I. , BORZENKOV M.I. , ZLOBIN S.N. , IZMEROV O.V.
Published: July 2021

The results of the study of methods for the development of the construction of the crew of railway locomotives using inertialess control of the properties of units and parts are presented. To improve the dynamic properties of the traction drive and optimize the modes of its operation by means of inertialess control, such physical effects as a change in the friction coefficient by the action of an electric current or a magnetic field on the contact zone of friction pairs can be used. The use of the principle of inertialess control to optimize the properties of nodes that affect the dynamic properties of the crew, has made it possible to obtain a number of patents proposed by the authors.
PRINCIPLE AND THEOREMS OF REVERSIONAL CALCULATION
Authors: BOKHONSKY A.I. , VARMINSKAYA N.I. , RYZHKOV A. I.
Published: July 2021

A reverse optimality principle (ROP) is formulated and an algorithm for its use for constructing optimal portable object movements is presented. Using an example, sufficient conditions for the extremality of the restored criterion functional are verified when constructing an optimal control of the «acceleration–deceleration» type. The following theorems were formulated and proved: on the numerical equality of integrals with different integral functions, on the minimum energy to achieve the goal of optimally controlled motion in the form of «acceleration–deceleration». Basing on the generalization of the results for optimal controls designing of the «acceleration–deceleration» type of motion, whence the known special cases follow, universal analytical control function (translational acceleration) was found. Analytically and numerically was confirmed the existence of the limiting minimum control energy at which the movement of an object from the initial state of rest to a new state of rest is possible at a fixed distance and time of motion.
STUDY OF THE MECHANICAL PROPERTIES OF THE FILAMENT DEPENDING ON THE PERCENTAGE OF FILLING WHEN PROTOTYPING THE PARTS OF MECHATRONIC COMPLEXES
Authors: RODICHEV A.Yu. , ТOKMAKOVA М.А. , VNUYKOV S.S. , GRYADUNOVA M.A.
Published: July 2021

The article contains an analysis of the applied thermoplastics used in prototyping parts of mechatronic complexes. Several types of experimental samples with different percent of filling are presented. Shown is the equipment on which the experimental studies were carried out. During the experiments, a specialized tensile testing machine was used. Experimental samples were installed in the developed centering device. Normal conditions were observed during the tests. The results of an experimental tensile study of PLA–plastic samples are presented. A characteristic stress–strain diagram of an experimental sample is described, which describes the dependence of stress on relative deformation. An equation of the linear dependence of the tensile strength on the percentage of filament filling has been compiled, which makes it possible to determine the ultimate strength of the product at any percentage of the filling of the plastic filament. Adequacy assessment is verified by Fisher's criterion. Recommendations are given on filament filling when prototyping machine parts.
IGBT CHIP TEMPERATURE CONTROL METHOD IN REAL TIME
Authors: GOSTENKOV E.V. , MISHIN V.V. , CHETVERIKOV D.A.
Published: July 2021

The work is devoted to the study of temperature–sensitive parameters of power IGBT transistors. A method for measuring IGBT temperature based on temperature–sensitive parameters is considered. An experimental estimate of the temperature dependence of the temperature–sensitive parameter Rgint.
OPTION OF HEAT PIPES FOR COOLING OF MOLDS DURING INJECTION MOLDING PLASTICS
Authors: GOGOLEV G.V.
Published: July 2021

In the article analyzed possibility using of heat pipes and two–phase thermal siphons in production plastic injection molding and die casting of zinc alloys. The advantages of heat pipes make it possible to use them to remove heat from hard–to–reach place of casting molds. Results of the comparative analyses of the work of various heat pipes are presented. The experimental researches were in the real temperature range of work carried out. The article gives recommendations on the option of capillary–porous structures and working fluids of heat pipes. The arterial heat pipe design proposed. The optimal geometric characteristics of mesh porous structure of this heat pipe are determined.
IMPROVING THE EFFICIENCY OF THE INSTALLATION FOR APPLYING THE POLYMER SHELL TO THE ABRASIVE UNDER CRITICAL TECHNOLOGICAL CONDITIONS
Authors: KOZHUS O.G. , BARSUKOV G.V. , SHORKIN V.S. , STEPANOV Yu. S. , FROLENKOVA L.Yu.
Published: July 2021

The article deals with the issues of increasing the productivity of the process of applying the polymer shell to the abrasive. It is established that the performance of the abrasive encapsulation in the fluidized bed is achieved due to the selection of equipment, the type of polymer, the spray parameters and the properties of the abrasive material. The authors have developed a method for producing abrasive grain with a polymer coating using an installation that allows processing the initial particles in a fluidized bed.
Determinants of Malaysian Household Purchase Decisions of Shellfish Products
Authors: TAN A.K.G. , LEE H.S.H.
Published: July 2021

The dichotomous choice Logit model is applied on the Malaysian Household Expenditure Survey (1998/99) data to identify the socio-demographic determinants of household purchase decisions of shellfish. Results indicate that decisions to purchase shellfish are significantly determined by age, race, education, and the levels of household size and income. In other words, while older households have a higher propensity to consume shellfish, all three major races in Malaysia demonstrate high probability levels to purchase shellfish. Furthermore, households with higher income levels and larger family sizes are more likely to purchase shellfish, while those who are more educated are less likely to expend on it. Based on these results, several observations are noted.
Successful Induced Spawning of Indian Major Carps Following Injection of Buserelin and Domperidone
Authors: BASAVARAJA N. , NANDEESHA M.C. , AKASH N. , RANGASWAMY B.L. , MAHESH T. , MURTHY C.K.
Published: July 2021

The major source of carp seed in India is from induced breeding and most seed farms in Karnataka State use ovaprim for commercial production of fish fry. The present study was conducted to investigate the possibility of employing a combination of buserelin (an analogue of mammalian LHRH) and domperidone (a dopamine antagonist) for the induced spawning of the three Indian major carps, viz. catla (Catla catla), rohu (Labeo rohita) and mrigal (Cirrhinus mrigala). All the three species could be successfully induced bred using a combination of mLHRH-a and domperidone (DOM) through a single injection. Important aspects of induced spawning such as breeding response, fecundity, latent period, fertilization rate and quantity of spawn obtained with mLHRH-a +DOM were compared with those of sGnRH-a and DOM combination (ovaprim), a widely used fish spawning agent in India. The breeding response of females of all the three species treated with mLHRHa+DOM was 100%, while it varied between 86 and 100% for sGnRH-a+DOM treated fish. The fecundity, fertilization rate and quantity of three-day-old spawn realized for the former combination were equal or better than those obtained for the latter. Among the different doses tested, 0.8, 0.7-0.8 and 0.7 mlxkg-1 body weight (b.w.) of female produced consistently good results in catla, rohu and mrigal, respectively. Lower doses (0.4-0.5 mlxkg-1 b.w.) also led to the mass spawning of mrigal, with fertilization rate ranging between 89 and 93%. In all the trials, the males received either sGnRH-a+DOM at 0.1-0.2 mlxkg-1 b.w. or mLHRH-a+DOM at one-third of the dose given to the female. The quality of carp seed produced through mLHRH-a+DOM was good and comparable to that obtained with sGnRH-a+DOM and it is more economical than the former spawning agent.
Nivel de adquisición de habilidades para el cuidado en internos hospitalarios de enfermería, Lambayeque 2020
Authors: Alarcón Vigil Gabriela Belén , Lázaro Alcántara Elaine
Published: July 2021

Objetivo: Determinar el nivel de adquisición de habilidades para el cuidado en internos hospitalarios de enfermería, Lambayeque 2020. Método: Enfoque cuantitativo, descriptivo simple. Población constituida por 132 internos de enfermería. Se aplicó como instrumento una escala de Likert, que evaluó el nivel de adquisición de habilidades para el cuidado, constituido por dos dimensiones con 21 ítems, que fue sometido a pruebas de validez, consistencia y confiabilidad, con el análisis juicio de expertos mediante la prueba binomial, llegándose a la conclusión la proporción de preguntas aceptadas por el juez N° 1, 2,3 para el instrumento es igual al 85%, lo cual es un valor aceptable y aplicando prueba piloto, utilizando el programa estadístico SPSS 25 se halló la validez obteniéndose un alfa de Cronbach de 0.672 lo cual indico que existe una confiabilidad buena y adecuada. Se tomó como base los criterios de rigor científico (validez interna y externa) y de los principios éticos (autenticidad, autonomía, no maleficencia y justicia). Los datos fueron procesados con el programa SPSS 25. Resultados: el 75,8% aseveró que su adquisición de habilidades fue muy buena durante su internado hospitalario y el 0,8% piensa que no. En las dimensiones principiante y principiante avanzado se obtuvo un nivel de adquisición de habilidades muy buena con un 64,4% y 81,8% respectivamente. Conclusión: la adquisición de habilidades fue muy bueno debido que los estudiantes reconocieron a sus prácticas preprofesionales como una oportunidad para lograr las competencias con la práctica constante en los diferentes servicios.

Palabras clave: Adquisición de habilidades, internado de enfermería, cuidado de enfermería.

Términos Decs: Habilidad (F02.784.629.131), cuidado (F01.752.355), enfermería (H02.478).
FUTURE CELLULOSE BASED INDUSTRIES IN BANGLADESH – A MINI REVIEW
Authors: SARKAR AKASH M. , FARZANA MAISHA , RAHMAN M. MOSTAFIZUR , JIN YANGCAN , JAHAN M. SARWAR
Published: July 2021

"Lignocellulosic products can contribute to a low carbon economy, which can support in achieving the sustainable development goals of a country. The demand for pulp and paper in the developing world is constantly increasing. Due to environmental awareness, interest in bio-based products is mounting, encouraging the establishment of integrated biorefineries. Bangladesh is facing an acute shortage of fibrous raw materials, as forest resources are limited. This paper provides an overview of the characteristics of raw materials that would be available for pulping to future pulp industries in Bangladesh. Rice straw is the most abundant raw material in Bangladesh, followed by wheat straw. However, both rice and wheat straws contain a very high amount of silica, which restricts their use in pulping. An alternative technology has been developed to overcome the drawbacks of non-wood pulping, where all dissolved biomass fractions are used in the development of bio-based products. "
PRODUCTION, OPTIMIZATION AND DEINKING CAPACITY OF ALKALINE CELLULASE PRODUCED FROM MUCOR CIRCINELLOIDES WSSDBS2F1
Authors: ABDULHADI YAKUBU , ASHISH VYAS
Published: July 2021

An alkaliphilic Mucor circinelloides WSSDBS2F1 strain, with the ability to produce endoglucanase and exoglucanase enzymes, was isolated from decomposing bagasse, originating from a sugar processing mill in Punjab, India, and then screened. A pH range of 7-11, temperature of 30-60 °C, incubation period of 4-12 days, different lignocellulosic waste and nitrogen sources were investigated for optimum production of cellulase enzyme. Response Surface Methodology (RSM) was the statistical tool used for optimization of endoglucanase and exoglucanase production, following the one-factor-at-a-time approach. The optimized endoglucanase was further evaluated for its ability to deink waste paper, compared to chemical deinking. It was found that the enzymatically deinked pulp had high ISO brightness, tensile, burst and tearing strength, as compared to chemically deinked and control pulps. Scanning electron microscopy and Fourier transform infrared spectroscopy (FTIR) were also used to confirm the action of the endoglucanase enzyme on waste paper.
EXPRESSION OF CELLULOSE-DEGRADING ENDOGLUCANASE FROM BACILLUS SUBTILIS USING PTOLT EXPRESSION SYSTEM IN ESCHERICHIA COLI
Authors: KUDUĞ CEYLAN HÜLYA , ULUSU YAKUP , BILGIN SEMA , GÖKÇE İSA
Published: July 2021

Endoglucanases randomly hydrolyse the cellulose chains by acting upon internal β-1,4-D-glycosidic bonds and are used extensively in industrial applications. In this study, bacterial endoglucanase gene yhfE was obtained by PCR, using primers based on genomic sequences of Bacillus subtilis strains. 1041 bp DNA fragment of yhfE was cloned into Escherichia coli DH5α through the use of pTolT expression plasmid. PCR, restriction enzyme analysis and DNA sequencing were performed in order to confirm the cloning. E. coli BL21-AI cells expressed the yhfE after induction at 0.04% of arabinose concentration for 4 h. The expected 38.7 kDa size yhfE protein after digestion with thrombin of the His-tagged fusion protein (yhfE-TolAIII) was visualized by SDS-PAGE. The yhfE-TolAIII production yield was approximately 82 mg/L. The recombinant yhfE was characterized by MALDI-TOF mass spectrometry and CD analysis.
DERIVATIVES: HEDGING AND SPECULATION
Authors: GOGOKHIA MAYA
Published: July 2021

The purpose of the article is to demonstrate: risks arising on the securities market, the goals of hedgers and speculators. The paper discusses the main features of derivatives (the most popular securities on the modern financial markets, such as futures, options, forwards)
EDUCATION AS A FACTOR OF EMPLOYMENT AND INCOME
Authors: KHURTSIA LALI , GAPRINDASHVILI GIORGI
Published: July 2021

The article deals with the analysis of the education role with regard to the impact on income and employment. To identify the link between education and unemployment, and education and income, CRRC secondary data is used. According to the analysis, the alternative cost for basic education is important, which allows the increased number of highly qualified staff and high quality of work efficiency in the future.
ENERGY SAVING AND INTENSIFICATION OF PRODUCTION
Authors: CHOMAKHIDZE DEMUR
Published: July 2021

The report analyzes the role and importance of energy conservation for Georgia. Based on concrete materials, the effectiveness of social labor and energy savings on gross domestic product (GDP) is comparable to each other. It is said that the reduction of GDP energy efficiency by 1% is almost the same, and in more than a few years, the result of GDP
increase is more than the same as the productivity of public labor. In this regard, the report describes the level and dynamics of major macroeconomic indicators of the economic development of Georgia for 2013-2016. Set up events to improve
the situation.
RESIDENTIAL TRANSACTIONS AS LEADING ECONOMIC INDICATOR
Authors: TOTLADZE LIA
Published: July 2021

It is important to predict trends of economic development for any country. Researchers and practitioners use different ways for evaluation and forecasting economic activity.
Identification of indicators, which change impact on the economy in general, is one of the widespread methods. The most appropriate tools to solve this problem are the leading indicators and indexes based on leading indicators. The selection of indicators depends on the specificity of the country’s economy. Among the leading economic indicators is the dynamics of applications for the Building permissions for private houses, and can also be successfully use residential transactions.
Depending on the above, the paper deals the aspects of calculation of leading economic indicators. This paper analyses some aspects of the effectiveness of indicator for predicting economic activity and describes the methodological issues
forward leading indicators. Particular attention is paid to analysis of residential transactions dynamics as a leading indicator as in theoretical as in practical terms. The article highlights the peculiarities of its implementation in Georgia.
THE IMPACT OF ECOLOGICAL FACTORS ON TOURISM DEVELOPMENT IN KVEMO KARTLI REGION
Authors: LETANDZE NINO
Published: July 2021

In this Article we discuss environmental issues necessary for safe and sustainable development of tourism as an integral part of economic relations. We focus to examine the impact of anthropogenic effects on the environment, which manifests itself in organizing recreational utilization of nature We refer here to the impact of ecological problems on
human health in Kvemo Kartli region, which is very attractive tourist destination and has a great potential for tourism development as of its cultural and historic heritage.
PENGARUH MOTIVASI DAN KOMPETENSI MELALUI TUGAS BELAJAR TERHADAP KINERJA PEGAWAI NEGERI SIPIL KABUPATEN BARITO SELATAN DI BUNTOK.
Authors: Ayi Syarif Hidayat
Published: July 2021

ABSTRAK

Kinerja Pegawai  Negeri Sipil merupakan salah satu faktor penentu baik tidak nya pelayanan di Kabupaten Barito Selatan. Beberapa faktor seperti motivasi dan kompetensi melalui tugas belajar diduga memberikan pengaruh terhadap kualitas kinerja pegawai negeri sipil Kabupaten Barito Selatan di Buntok. Penelitaian ini bertujuan untuk menguji pengaruh motivasi dan kompetensi melalui tugas belajar terhadap kinerja pegawai negeri sipil kabupaten barito selatan di buntok. Objek penelitian adalah Pegawai Negeri Sipil yang sudah selesai menjalani Tugas Belajar maupun Pegawai Negeri Sipil yang sedang menjalani Tugas Belajar dengan pembiayaan melalui APBD Kabupaten Barito Selatan. Penentuan sampel dalam penelitian ini menggunakan simple random sampling, dengan sampel sebanyak 71 responden. Variabel bebas dalam penelitian ini adalah Motivasi dan Kompetensi, dengan Tugas Belajar sebagai variabel interveningnya, sedangkan variabel terikat nya adalah kinerja Pegawai Negeri Sipil. Teknik analisis yang digunakan dalam penelitian ini menggunakan analisis jalur (Path Analysis) dengan bantuan program SPSS. Hasil penelitian menunjukkan bahwa (1) Motivasi memiliki pengaruh secara langsung pada Tugas Belajar seperti yang ditunjukkan oleh nilai betacoefficient standar yang positif sebesar 0,444 dan nilai thitung 4,361, lebih besar dari ttabel 1,671. Dengan demikian, hipotesis diterima (2) Kompetensi memiliki pengaruh secara langsung pada Tugas Belajar yang ditunjukkan oleh nilai betacoefficient standar positif sebesar 0,427 dan thitung 4,195, lebih besar dari ttabel 1,671. Dengan demikian, hipotesis diterima (3) Motivasi memiliki pengaruh secara langsung pada Kinerja Pegawai Negeri Sipil dengan nilai standar positif yang dibakukan sebesar 0,235 dan thitung 3,391, lebih besar dari ttabel 1,671. Dengan demikian, hipotesis diterima. (4) Kompetensi memiliki pengaruh secara langsung terhadap Kinerja Pegawai Negeri Sipil. Hal ini ditunjukkan oleh nilai betacoefficient standar positif sebesar 0,176 dan thitung 2,553, lebih besar dari pada ttabel 1,671. Dengan demikian, hipotesis diterima. (5) Tugas Belajar memiliki pengaruh positif secara langsung pada Kinerja Pegawai Negeri Sipil seperti yang ditunjukkan oleh nilai betacoefficient standar positif yang dibakukan antara 0,619 dan thitung 7,913, lebih besar dari ttabel 1,671. Dengan demikian, hipotesis diterima.

Kata Kunci   :    Motivasi, Kompetensi, Tugas Belajar, Kinerja Pegawai Negeri Sipil
ANATOMICAL VARIATIONS OF PANCREATIC DUCTS
Authors: Indra Nath Sutia , Anuradha Baruah , Ankita Borah
Published: July 2021

Background: Anatomical variations and congenital anomalies of the pancreatic ducts are often detected as incidental ndings in asymptomatic
patients and are commonly encountered in radiological investigations. Anatomical knowledge of the pancreatic ducts and its variations are
important to avoid pancreatic injury during surgical and investigative procedure. The Objectives: aim of the present study is to study anatomical
variation of the pancreatic ducts. Methods: The study was done in the department of Anatomy, Assam Medical College, Dibrugarh, Assam. 50
specimens were collected, (35 nos perinatal and 15 nos adult). A thorough morphological study of the pancreatic duct system was carried out and
the results were recorded. Variations of the pancreatic ducts & their diffe Results: rent types correlate with the previous studies to some extent.
Conclusion: Knowledge of the pattern and anomaly of the pancreatic ducts will add in the long list of variations of the pancreas. It will be helpful
for safe and effective diagnostic and therapeutic interventions and prevention of inadvertent organ damage or ductal injury.
BODY MASS INDEX AND IT’S ASSOCIATION WITH DIABETIC RETINOPATHY IN TYPE 2 DM
Authors: kumar samota Mukesh , bijarnia Mamta
Published: July 2021

1.BACKGROUND: Overweight and obesity are global public health problem with increasing prevalence worldwide1-3. It is a risk factor for
many metabolic and cardiovascular diseases including type 2 diabetes, hypertension, and dyslipidaemia etc4. Diabetic retinopathy (DR) is the
common micro vascular complication of diabetes mellitus (DM) and a leading cause of acquired blindness in adults. The aim of this study is nd
relationship between different BMI classes and DR development in type 2 diabetic patients.
2. AIMS AND OBJECTIVES:To determine the association of BMI and diabetic retinopathy and risk factors for DR
3. MATERIALS AND METHODS: A total of 206 type 2 diabetes patients from medicine ward of Swai man singh hospital and college Jaipur
[Rajasthan]. The subjects were classied into one of the three categories according to the BMI. (1).Normal BMI 18.5–24.9 kg/m2; (2).Overweight
BMI 25–29.9 kg/m2.(3).Obese BMI ≥30 kg/m2. Blood samples were collected after overnight fasting. Glycated haemoglobin value (HbA1c), total
cholesterol and triglycerides were measured. Complete eye examination included best corrected visual acuity (BCVA), slit lamp microscopy, and
fundus examination with binocular indirect ophthalmoscope and plus 20D lens after mydriasis with topically administrated 1% tropicamide and
5% phenylephrine eye drops was done. According to the DR status, patients were divided into two groups: group 1 (no retinopathy; N= 168), group
2 diabetic retinopathy; N= 38)
RESULT: Duration of type 2 diabetes was found longer with group 2 (9.6±4.5 years) as compare with group 1 (16.82±7.21 years). Association of
body mass index (BMI) of type 2 diabetic patients (n =206) with diabetic retinopathy, no correlation was found with mean BMI in group 1 (25.48 ±
2.4) and group 2 (27.21± 2.0)( P value <0.1). In our study were found signicant correlation of HbA1c with DR (p value <.01). Mean value of
HbA1c was higher in group 2 (8.41±.6) as compare with group 1 (7.01±.8). We found a signicant increase in total cholesterol (P <.01),
triglycerides (P< 0.05) with the diabetic retinopathy
SURGICAL MANAGEMENT OF COMPLETE VASCULAR RINGS: OUR EXPERIENCE
Authors: Chugh Vaibhav , Bhushan Rahul , Jhajhria Narender Singh , Bansal Dhananjay , Aiyer Palash , Grover Vijay , Gupta V.K
Published: July 2021

Vascular rings are rare congenital aortic arch anomalies that may cause trachea-esophageal compressive symptoms in infants and children. It may
be asymptomatic in few cases. Due to its rare occurrence and non-specic symptoms, the diagnosis is often missed, thus delaying the treatment.
With this case series we share our experience of managing four cases of vascular rings over four years, with age of patients ranging from 3 months to
3 years. All cases presented in pediatric emergency with trachea-esophageal compressive symptoms. In our series we encountered 4 types of
complete vascular rings- Left Pulmonary Artery (LPA) sling with Left Ligamentum (LL), Right Aortic Arch with aberrant Left Subclavian Artery
from Kommerell diverticulum with LL, Right dominant Double Aortic Arch (DAA) with associated TOF, and DAA with left dominant arch. Two
cases had associated cardiac anomalies, which were Atrial Septal Defect (ASD) and Tetralogy Of Fallot (TOF). Median sternotomy was done in
two cases with associated cardiac anomalies and left thoracotomy was the approach for rest two cases. Single stage single incision approach was
followed in all cases, with no postoperative mortality and no signicant morbidity. Early diagnosis and precise planning of surgical intervention
provides the best long-term outcomes.
COMPARISON OF HUMANPAPILLOMAVIRUS MESSANGER(E6)RNA EXPRESSION AND DNA AS BIOMARKER IN SCREENING OF VIAVILI POSITIVE CASES IN TERTIARY CARE
Authors: Vallabi R. , Rama K. , Hemalatha S.
Published: July 2021

Cervical cancer is second most frequent cancer of women in the world. HPV infection is now a well established cause of cervical cancer . Currently
used screening programmes are detecting cases in which only 15-20 percent of women found to have an abnormality signicant enough to need
treatment, other 80-85 percent were probably false alarms. The oncogenic process in cervical cancer is initiated and mediated by upregulation of
E6/E7 mRNA proteins and their over expression. So HPV E6 mRNA detection as a triage test could actually detect a neoplastic transformation and
may help to reduce the false alarms. To compare the expression of HPV E6 mRN AIMS AND OBJECTIVES : A verses the HPV DNA as a
biomarker in the screening of cervical cancer .Biopsy is used as gold standard for screening. This a prospective MATERIALSAND METHODS:
study conducted in Institute of Social Obstetrics and Govt. Kasturba Gandhi hospital, Madras medical college, 41 cases positive for VIA/VILI in
colposcopy were selected and subjected to conventional cytology and cervical biopsy ,part of biopsy was collected in RNA later solution and were
typed for HPV DNA 16& 18,HPV E6mRNA Expression.the results of above test are compared with histopathology as gold standard. RESULTS:
The specicity of E6 mRNA was 100% for both high grade and low grade lesions.But the sensitivity was less than HPV DNA and cytology for
both low and high grade lesions.With increasing severity of lesion expression of E6 mRNA was found to increase. Low positivity CONCLUSION:
rate and the high specicity makes E6 mRNA better biomarker in a screening of cervical cancer.
New horizons for insulin therapy with a pump: the artificial pancreas
Authors: Papa, G.
Published: July 2021

The monitoring and treatment of type 1 diabetes (T1D) are undergoing profound changes today. Notable steps include the improvement and widespread adoption of glucose sensors which are now extremely reliable and furthermore are used with insulin pumps in an integrated manner. Over the last 2 to 3 years these systems have evolved rapidly with the development and use of algorithms which permit the autonomous regulation of basal insulin. Correct control and administration of basal insulin is often the greatest stumbling block in multiple daily injection therapy as basal insulins cannot replicate the physiological rhythms of basal insulin secretion. Hypoglycemia is another critical point in standard insulin pen therapy as it does not permit dosage modulation in the same way as with an insulin pump. In this article we cover the fundamental steps in this revolution of insulin therapy which promises, in the not too distant future, the ultimate achievement of the artificial pancreas and thus the complete closure of the loop. All those working in diabetes care must be adequately trained and familiar with this technology as it should no longer be considered a niche treatment reserved for carefully selected patients and managed in only a few centers of excellence. In order to choose the best treatment, tailored to each individual patient’s needs, medical staff involved in the treatment of T1D require a thorough knowledge of standalone glucose sensors, insulin pumps and integrated systems with control algorithms.Once the critical issues (costs, psychological aspects, system management difficulties, alarm fatigue, etc.) still related to their use have been resolved, new Hybrid Closed Loop and Advanced Hybrid Closed Loop systems could become the new standard in the treatment of T1D. KEY WORDS type 1 Diabetes; insulin pump; decision-making algorithms; integrated system.
Diabetes management in telemedicine: patients’ opinion (preliminary data)
Authors: Foglia, A.
Published: July 2021

With the outbreak of the COVID-19 pandemic and the resulting restrictions, telemedicine has enabled healthcare to be provided to patients with chronic diseases, although with some restrictions. During the lockdown The Campania region was the first to order (03/27/2020), to protect the health of citizens suffering from diabetes mellitus, the use of telemedicine and a tele-health service was activated in our clinics. At the end of the consultation, a survey was submitted to our diabetic patients in order to evaluate their opinion about the telemedicine experience in comparison with the traditional clinic visit. 100% of both type 1 and type 2 patients consider the telemedicine visit adequate, 89.2% of types 1 and 75.9% of types 2 consider the two forms of visit absolutely overlapping from a professional point of view, and even 6.9% of type 2, but none of type 1, considers the tele-visit more effective than the traditional visit. However, only 44.8% (type 2 diabetic patients) and 13,5%% (type 1 diabetic patients) expressed a preference for telemedicine visits over traditional visits. Telemedicine has allowed continuity of care for diabetic patients despite the difficulties of this emergency time. We believe that the opinion of patients and health care professionals on the telemedicine experience can be useful to assess the limitations and advantages in order to improve and enhance the use of this method. KEY WORDS diabetes mellitus; telemedicine system; survey.
Risk of infection in diabetes before and during COVID-19: a review
Authors: Adinolfi, V.
Published: July 2021

The risk of almost all types of infection is increased both in type 1 and type 2 diabetic patients. Notably, infections are one of the most important cause of hospitalization and death in diabetes and the risk is increased in patients with poor glycemic control. SARS-CoV2 pandemic stressed this association, since diabetic patients showed a particularly high risk of worse outcomes. This review analyzes the association of diabetes and different infections, underlining how the risk of worse outcomes was present both before and during SARS-CoV2 pandemic. KEY WORDS COVID-19; infection; diabetes; immunology; susceptibility.