bluuebunny/crossref_metadata_2025 huggingface dataset:
miR-429 regulates the transition between Hypoxia-Inducible Factor (HIF)1A and HIF3A expression in human endothelial cells
Authors: Janaszak-Jasiecka Anna , Bartoszewska Sylwia , Kochan Kinga , Piotrowski Arkadiusz , Kalinowski Leszek , Kamysz Wojciech , Ochocka Renata J. , Bartoszewski Rafał , Collawn James F.
Published: March 2016

Hypoxia-inducible factors (HIF) are heterodimeric transcription factors that allow cells to adapt and survive during hypoxia. Regulation of HIF1A and HIF2A mRNA is well characterized, whereas HIF3A mRNA regulation and function are less clear. Using RNA-Seq analysis of primary human umbilical vein endothelial cells, we found two isoforms of HIF3A were expressed, HIF3A2 and HIF3A3. Comparing HIF3A expression profiles to HIF1A mRNA during 48 hours of hypoxia revealed that HIF1A message peaked at 4 hours, whereas HIF3A expression increased while HIF1A was decreasing. Given that HIF1A mRNA is regulated by miR-429, we tested miR-429 effects on both HIF3A isoforms and found that they too were regulated by miR-429. Analysis of a HIF-3 target, DNA-damage-inducible transcript 4, a key survival gene, indicated that DDIT4 mRNA is induced by HIF-3 and negatively regulated by miR-429 through miR-429’s actions on HIF3A message. This provides a compelling model for how hypoxia-induced miR-429 regulates the switch between HIF-1 adaptive responses to HIF-3 survival responses by rapidly decreasing HIF1A levels while simultaneously slowing the progression of HIF3A expression until the miR-429 levels drop below normoxic levels. Since HIF-1 drives HIF3A and miR-429 expression, this establishes a regulatory network in which miR-429 plays a pivotal role.
Environmental and Historical Determinants of Patterns of Genetic Differentiation in Wild Soybean (Glycine soja Sieb. et Zucc)
Authors: He Shui-Lian , Wang Yun-Sheng , Li De-Zhu , Yi Ting-Shuang
Published: March 2016

Wild soybean, the direct progenitor of cultivated soybean, inhabits a wide distribution range across the mainland of East Asia and the Japanese archipelago. A multidisciplinary approach combining analyses of population genetics based on 20 nuclear microsatellites and one plastid locus were applied to reveal the genetic variation of wild soybean, and the contributions of geographical, environmental factors and historic climatic change on its patterns of genetic differentiation. High genetic diversity and significant genetic differentiation were revealed in wild soybean. Wild soybean was inferred to be limited to southern and central China during the Last Glacial Maximum (LGM) and experienced large-scale post-LGM range expansion into northern East Asia. A substantial northward range shift has been predicted to occur by the 2080s. A stronger effect of isolation by environment (IBE) versus isolation by geographical distance (IBD) was found for genetic differentiation in wild soybean, which suggested that environmental factors were responsible for the adaptive eco-geographical differentiation. This study indicated that IBE and historical climatic change together shaped patterns of genetic variation and differentiation of wild soybean. Different conservation measures should be implemented on different populations according to their adaptive potential to future changes in climate and human-induced environmental changes.
Spatially multiplexed dark-field microspectrophotometry for nanoplasmonics
Authors: Pini V. , Kosaka P. M. , Ruz J. J. , Malvar O. , Encinar M. , Tamayo J. , Calleja M.
Published: March 2016

Monitoring the effect of the substrate on the local surface plasmon resonance (LSPR) of metallic nanoparticles is key for deepening our understanding of light-matter interactions at the nanoscale. This coupling gives rise to shifts of the LSPR as well as changes in the scattering pattern shape. The problem requires of high-throughput techniques that present both high spatial and spectral resolution. We present here a technique, referred to as Spatially Multiplexed Micro-Spectrophotometry (SMMS), able to perform polarization-resolved spectral and spatial analysis of the scattered light over large surface areas. The SMMS technique provides three orders of magnitude faster spectroscopic analysis than conventional dark-field microspectrophotometry, with the capability for mapping the spatial distribution of the scattered light intensity with lateral resolution of 40 nm over surface areas of 0.02 mm2. We show polarization-resolved dark-field spectral analysis of hundreds of gold nanoparticles deposited on a silicon surface. The technique allows determining the effect of the substrate on the LSPR of single nanoparticles and dimers and their scattering patterns. This is applied for rapid discrimination and counting of monomers and dimers of nanoparticles. In addition, the diameter of individual nanoparticles can be rapidly assessed with 1 nm accuracy.
Delta-proteobacterial SAR324 group in hydrothermal plumes on the South Mid-Atlantic Ridge
Authors: Cao Huiluo , Dong Chunming , Bougouffa Salim , Li Jiangtao , Zhang Weipeng , Shao Zongze , Bajic Vladimir B. , Qian Pei-Yuan
Published: March 2016

In the dark ocean, the SAR324 group of Delta-proteobacteria has been associated with a chemolithotrophic lifestyle. However, their electron transport chain for energy generation and information system has not yet been well characterized. In the present study, four SAR324 draft genomes were extracted from metagenomes sampled from hydrothermal plumes in the South Mid-Atlantic Ridge. We describe novel electron transport chain components in the SAR324 group, particularly the alternative complex III, which is involved in energy generation. Moreover, we propose that the C-type cytochrome, for example the C553, may play a novel role in electron transfer, adding to our knowledge regarding the energy generation process in the SAR324 cluster. The central carbon metabolism in the described SAR324 genomes exhibits several new features other than methanotrophy e.g. aromatic compound degradation. This suggests that methane oxidation may not be the main central carbon metabolism component in SAR324 cluster bacteria. The reductive acetyl-CoA pathway may potentially be essential in carbon fixation due to the absence of components from the Calvin-Benson cycle. Our study provides insight into the role of recombination events in shaping the genome of the SAR324 group based on a larger number of repeat regions observed, which has been overlooked thus far.
Optically tuned terahertz modulator based on annealed multilayer MoS2
Authors: Cao Yapeng , Gan Sheng , Geng Zhaoxin , Liu Jian , Yang Yuping , Bao Qiaoling , Chen Hongda
Published: March 2016

Controlling the propagation properties of terahertz waves is very important in terahertz technologies applied in high-speed communication. Therefore a new-type optically tuned terahertz modulator based on multilayer-MoS2 and silicon is experimentally demonstrated. The terahertz transmission could be significantly modulated by changing the power of the pumping laser. With an annealing treatment as a p-doping method, MoS2 on silicon demonstrates a triple enhancement of terahertz modulation depth compared with the bare silicon. This MoS2-based device even exhibited much higher modulation efficiency than the graphene-based device. We also analyzed the mechanism of the modulation enhancement originated from annealed MoS2 and found that it is different from that of graphene-based device. The unique optical modulating properties of the device exhibit tremendous promise for applications in terahertz switch.
Reduced sleep duration mediates decreases in striatal D2/D3 receptor availability in cocaine abusers
Authors: Wiers C E , Shumay E , Cabrera E , Shokri-Kojori E , Gladwin T E , Skarda E , Cunningham S I , Kim S W , Wong T C , Tomasi D , Wang G-J , Volkow N D
Published: March 2016

Neuroimaging studies have documented reduced striatal dopamine D2/D3 receptor (D2/D3R) availability in cocaine abusers, which has been associated with impaired prefrontal activity and vulnerability for relapse. However, the mechanism(s) underlying the decreases in D2/D3R remain poorly understood. Recent studies have shown that sleep deprivation is associated with a downregulation of striatal D2/D3R in healthy volunteers. As cocaine abusers have disrupted sleep patterns, here we investigated whether reduced sleep duration mediates the relationship between cocaine abuse and low striatal D2/D3R availability. We used positron emission tomography with [11C]raclopride to measure striatal D2/D3R availability in 24 active cocaine abusers and 21 matched healthy controls, and interviewed them about their daily sleep patterns. Compared with controls, cocaine abusers had shorter sleep duration, went to bed later and reported longer periods of sleep disturbances. In addition, cocaine abusers had reduced striatal D2/D3R availability. Sleep duration predicted striatal D2/D3R availability and statistically mediated the relationship between cocaine abuse and striatal D2/D3R availability. These findings suggest that impaired sleep patterns contribute to the low striatal D2/D3R availability in cocaine abusers. As sleep impairments are similarly observed in other types of substance abusers (for example, alcohol and methamphetamine), this mechanism may also underlie reductions in D2/D3R availability in these groups. The current findings have clinical implications suggesting that interventions to improve sleep patterns in cocaine abusers undergoing detoxification might be beneficial in improving their clinical outcomes.
Association of thalamic hyperactivity with treatment-resistant depression and poor response in early treatment for major depression: a resting-state fMRI study using fractional amplitude of low-frequency fluctuations
Authors: Yamamura T , Okamoto Y , Okada G , Takaishi Y , Takamura M , Mantani A , Kurata A , Otagaki Y , Yamashita H , Yamawaki S
Published: March 2016

Despite novel antidepressant development, 10–30% of patients with major depressive disorder (MDD) have antidepressant treatment-resistant depression (TRD). Although new therapies are needed, lack of knowledge regarding the neural mechanisms underlying TRD hinders development of new therapeutic options. We aimed to identify brain regions in which spontaneous neural activity is not only altered in TRD but also associated with early treatment resistance in MDD. Sixteen patients with TRD, 16 patients with early-phase non-TRD and 26 healthy control (HC) subjects underwent resting-state functional magnetic resonance imaging. To identify brain region differences in spontaneous neural activity between patients with and without TRD, we assessed fractional amplitude of low-frequency fluctuations (fALFF). We also calculated correlations between the percent change in the Hamilton Rating Scale for Depression (HRSD17) scores and fALFF values in brain regions with differing activity for patients with and without TRD. Patients with TRD had increased right-thalamic fALFF values compared with patients without TRD. The percent change in HRSD17 scores negatively correlated with fALFF values in patients with non-TRD. In addition, patients with TRD showed increased fALFF values in the right inferior frontal gyrus (IFG), inferior parietal lobule (IPL) and vermis, compared with patients with non-TRD and HC subjects. Our results show that spontaneous activity in the right thalamus correlates with antidepressant treatment response. We also demonstrate that spontaneous activity in the right IFG, IPL and vermis may be specifically implicated in the neural pathophysiology of TRD.
Improvement of the gas cluster ion beam-(GCIB)-based molecular secondary ion mass spectroscopy (SIMS) depth profile with O2+ cosputtering
Authors: Chu Yi-Hsuan , Liao Hua-Yang , Lin Kang-Yi , Chang Hsun-Yun , Kao Wei-Lun , Kuo Ding-Yuan , You Yun-Wen , Chu Kuo-Jui , Wu Chen-Yi , Shyue Jing-Jong
Published: March 2016

The Ar2500+ and O2+ cosputter in ToF-SIMS depth profiles retained >95% molecular ion intensity in the steady-state.
Cooperative catalysis for the direct hydrodeoxygenation of vegetable oils into diesel-range alkanes over Pd/NbOPO4
Authors: Xia Qineng , Zhuang Xiaojing , Li Molly Meng-Jung , Peng Yung-Kang , Liu Guoliang , Wu Tai-Sing , Soo Yun-Liang , Gong Xue-Qing , Wang Yanqin , Tsang Shik Chi Edman
Published: March 2016

Near quantitative carbon yields of diesel-range alkanes are achieved from hydrodeoxygenation of triglycerides over Pd/NbOPO4 with no catalyst deactivation.
In situ generated polysiloxanes stabilizing μ3-oxo bridged Sb3 triangles
Authors: Santhana Raj Prabhu M. , Ugandhar Uppara , Baskar Viswanathan
Published: March 2016

The reaction of RSbO3H2 with t-butylsilanetriol has led to the isolation of organoantimony(v) based molecular triangles stabilized by siloxane frameworks.
Synthesis and structural properties of thermoelectric Ca3−xAgxCo4O9+δ powders
Authors: Park Kyeongsoon , Hakeem Deshmukh Abdul , Cha Jae Sung
Published: March 2016

The high-resolution Co 2p spectra of Ca3Co4O9+δ powders are deconvoluted into two spin–orbit doublets and three satellite peaks. The deconvoluted peaks at 780.3 and 796.0 eV correspond to Co2+ and those at 779.3 and 794.5 eV correspond to Co3+; the satellite peaks at 782.1, 789.5 and 804.2 eV correspond to Co4+, Co3+, and Co2+, respectively.
Silencing of USP22 suppresses high glucose-induced apoptosis, ROS production and inflammation in podocytes
Authors: Shi Jian-xia , Wang Qi-jin , Li Hui , Huang Qin
Published: March 2016

Silencing of USP22 suppresses high glucose-induced podocyte injury.
Towards an efficient blue emission cationic Ir(iii) complex with azole-type ancillary ligands: a joint theoretical and experimental study
Authors: Huang Shao-Fen , Sun Hai-Zhu , Shan Guo-Gang , Wu Yong , Zhang Min , Su Zhong-Min
Published: March 2016

A highly efficient blue emitting cationic Ir(iii) complex based on 1,2,4-triazole-pyridine ligands modified by a simple methyl moiety is reported.
Recent developments in the catalytic hydrogenation of CO2 to formic acid/formate using heterogeneous catalysts
Authors: Gunasekar Gunniya Hariyanandam , Park Kwangho , Jung Kwang-Deog , Yoon Sungho
Published: March 2016

This review highlights the recent trends in the heterogeneous hydrogenation of CO2 to formic acid/formate.
Ion specific effects on the stability of layered double hydroxide colloids
Authors: Pavlovic Marko , Huber Robin , Adok-Sipiczki Monika , Nardin Corinne , Szilagyi Istvan
Published: March 2016

Multivalent counterions are effective destabilization agents for layered double hydroxides due to their strong adsorption on the particle surface.
Hydrogen-treated mesoporous WO3 as a reducing agent of CO2 to fuels (CH4 and CH3OH) with enhanced photothermal catalytic performance
Authors: Wang Lichao , Wang Yu , Cheng Yao , Liu Zhifu , Guo Qiangsheng , Ha Minh Ngoc , Zhao Zhe
Published: March 2016

A series of mesoporous WO3 catalysts were facilely synthesized by a hydrothermal method using mesoporous silica KIT-6 as a hard template and silicotungstic acid as a precursor.
Determination of diethanolamine in cosmetics based on micellar extraction in situ derivatization coupled with high performance liquid chromatography
Authors: Li Xiaowan , Shi Jinjiao , Chen Ligang , Liu Yuqi
Published: March 2016

A schematic of the derivatization, extraction and enrichment achieved by this method.
Metal catalyst-free substitution of allylic and propargylic phosphates with diarylmethyl anions
Authors: Kawashima Hidehisa , Ogawa Narihito , Saeki Ryohei , Kobayashi Yuichi
Published: March 2016

Substitution of secondary allylic and propargylic phosphates with the anions derived from Ar2CH2 with BuLi or LDA proceeded regioselectively and stereoselectively without a metal catalyst, affording inversion products in good yields.
Exploiting redox activity in metal–organic frameworks: concepts, trends and perspectives
Authors: D'Alessandro D. M.
Published: March 2016

This feature article highlights latest developments in experimental, theoretical and computational concepts relevant to redox-active metal–organic Frameworks.
Mitochondria-specific conjugated polymer nanoparticles
Authors: Twomey Megan , Mendez Eladio , Manian Rajesh Kumar , Lee Sunwoo , Moon Joong Ho
Published: March 2016

Biodegradable conjugated polymer nanoparticles (CPNs) exhibit high mitochondrial localization upon endocytosis, fragmentation, and trafficking to mitochondria.
Anisotropic Li intercalation in a LixFePO4 nano-particle: a spectral smoothed boundary phase-field model
Authors: Hong L. , Liang L. , Bhattacharyya S. , Xing W. , Chen L. Q.
Published: March 2016

Spectral smoothed boundary phase-field model for studying phase transformation and implementing boundary conditions in a heterogeneous composite electrode.
Nucleophilic substitution by amide nitrogen in the aromatic rings of [zn− H]˙+ions; the structures of the [b2− H − 17]˙+and [c1− 17]+ions
Authors: Mu Xiaoyan , Lau Justin Kai-Chi , Lai Cheuk-Kuen , Siu K. W. Michael , Hopkinson Alan C. , Chu Ivan K.
Published: March 2016

Residue-specific [c1− 17]+and [b2− H − 17]˙+fragment ions reveal a novel cyclic rearrangement between peptide backbones and sidechains.
Mechanisms and reactivity differences of proline-mediated catalysis in water and organic solvents
Authors: Yang Gang , Zhou Lijun
Published: March 2016

Several key issues regarding the mechanisms of proline catalysis are unravelled by first-principles calculations that can guide future catalyst design.
Reactivity of diatomics and of ethylene on zeolite-supported 13-atom platinum nanoclusters
Authors: Keppeler M. , Bräuning G. , Radhakrishnan S. G. , Liu X. , Jensen C. , Roduner E.
Published: March 2016

CO and NO react on hydrogen-covered 13-atom Pt clusters, O2 does not, and the hydrogenation of ethene shows structure sensitivity.
Isomerization of the osmium–tellurium cluster Os3(μ-TeR)2(CO)10: a kinetic and computational study
Authors: Shim E. K. S. , Leong W. K. , Li Y.-Z. , Richmond M. G.
Published: March 2016

The kinetics for the isomerization of the 50e cluster Os3(μ-TeTol-p)2(CO)10 (3), where the tellurides bridge two different Os–Os edges, to one in which the tellurides bridge the same open Os⋯Os edge (4) have been measured experimentally by 1H NMR spectroscopy.
New fluoroborate Cd8B5O15F with two different isolated borate anions prepared by an open high-temperature solution method
Authors: Yang Yun , Dong Xiaoyu , Pan Shilie
Published: March 2016

The first cadmium fluoroborate Cd8B5O15F containing two different isolated anions BO3and B(O/F)4was prepared by the open high-temperature solution method.
A nano-structured RuO2/NiO cathode enables the operation of non-aqueous lithium–air batteries in ambient air
Authors: Tan P. , Wei Z. H. , Shyy W. , Zhao T. S. , Zhu X. B.
Published: March 2016

A cathode composed of RuO2 nanoparticle-decorated NiO nanosheets not only catalyzes the oxygen reduction and evolution reactions, but also promotes the decomposition of the side products (LiOH and Li2CO3), enabling a non-aqueous lithium–air battery to be truly operated in ambient air.
Gold nanorod synthesis catalysed by Au clusters
Authors: Attia Yasser A. , Vázquez-Vázquez Carlos , Blanco M. Carmen , Buceta David , López-Quintela M. Arturo
Published: March 2016

Gold nanorods have been successfully synthesized by the seed mediated method using Au clusters. This synthesis does not require silver ions to obtain large amounts of Au nanorods and has good control over their aspect ratio. Au clusters are produced with the same recipe as for Au seeds, but using shorter reaction times. This very simple scheme confirms the important catalytic influence of clusters in the anisotropic growth control.
Illuminating drug action by network integration of disease genes: a case study of myocardial infarction
Authors: Wang Rui-Sheng , Loscalzo Joseph
Published: March 2016

Illuminating the mechanisms of action of drugs used for myocardial infarction (MI) and the cardiovascular effects of non-MI drugs.
Rationalization of the selectivity between 1,3- and 1,2-migration: a DFT study on gold(i)-catalyzed propargylic ester rearrangement
Authors: Jiang Jingxing , Liu Yan , Hou Cheng , Li Yinwu , Luan Zihong , Zhao Cunyuan , Ke Zhuofeng
Published: March 2016

A general theoretical mode, based on the resonance structure of gold activated propargylic ester complexes, is presented to rationalize the regioselectivity of the gold catalyzed rearrangement of propargylic esters.
Pentavalent pillar[5]arene-based glycoclusters and their multivalent binding to pathogenic bacterial lectins
Authors: Galanos Nicolas , Gillon Emilie , Imberty Anne , Matthews Susan E. , Vidal Sébastien
Published: March 2016

Anti-adhesive glycoclusters offer potential as therapeutic alternatives to classical antibiotics in treating infections.
Maltotriose-conjugation to a fluorinated chlorin derivative generating a PDT photosensitizer with improved water-solubility
Authors: Narumi Atsushi , Tsuji Takahiro , Shinohara Kosuke , Yamazaki Hiromi , Kikuchi Moriya , Kawaguchi Seigou , Mae Tomoya , Ikeda Atsushi , Sakai Yuichi , Kataoka Hiromi , Inoue Masahiro , Nomoto Akihiro , Kikuchi Jun-ichi , Yano Shigenobu
Published: March 2016

A chlorin derivative was encircled with four maltotriose (Mal3) molecules to produce an oligosaccharide-conjugate meeting the requirements of a third generation photodynamic therapy (PDT) photosensitizer.
Probing the self-assembly and stability of oligohistidine based rod-like micelles by aggregation induced luminescence
Authors: Frisch Hendrik , Spitzer Daniel , Haase Mathias , Basché Thomas , Voskuhl Jens , Besenius Pol
Published: March 2016

The synthesis and self-assembly of a newC2-symmetric oligohistidine amphiphile equipped with an aggregation induced emission luminophore is reported.
Preparation of PE/GO nanocomposites using in situ polymerization over an efficient, thermally stable GO-supported V-based catalyst
Authors: Zhang He-Xin , Hu Yan-Ming , Lee Dong-Ho , Yoon Keun-Byoung , Zhang Xue-Quan
Published: March 2016

In this research, the high performance PE/GO nanocomposites were prepared by using a highly active, thermally stable GO-supported VOCl3-based catalyst through an in situ polymerization method.
Newly reduced graphene oxide/gold oxide neural-chemical interface on multi-channel neural probes to enhance the electrochemical properties for biosensors
Authors: Liu Ta-Chung , Chu Chao-Yi , Chen You-Yin , Chen San-Yuan
Published: March 2016

The newly neural-chemical interface designed by rGO-wrapped gold oxide nanocomposites on multi-channel neural probes as a biosensor.
Highly sensitive and selective “naked eye” sensing of Cu(ii) by a novel amido–imine based receptor: a spectrophotometric and DFT study with practical application
Authors: Bhattacharyya Arghyadeep , Ghosh Soumen , Guchhait Nikhil
Published: March 2016

Synthesis of (E)-bis-N'-((1H-pyrrol-2-yl)-methylene)-pyridine-2,6-carbohydrazide and its sensing ability towards copper(ii) ion in aqueous medium by color change, the sensing limit being 4.0 × 10−9 M.
Efficient and selective green oxidation of alcohols by MOF-derived magnetic nanoparticles as a recoverable catalyst
Authors: Yao Xianfang , Bai Cuihua , Chen Junying , Li Yingwei
Published: March 2016

A magnetic Fe3O4@C heterogeneous catalyst derived from MOFs is highly efficient and selective in oxidation of alcohols with neat water and base-free conditions.
Insight into the antioxidant properties of non-phenolic terpenoids contained in essential oils extracted from the buds of Cleistocalyx operculatus: a DFT study
Authors: Ngo Thi Chinh , Dao Duy Quang , Thong Nguyen Minh , Nam Pham Cam
Published: March 2016

The antioxidant properties of 21 non-phenolic terpenoids contained in essential oil extracted from the buds of Cleistocalyx operculatus have been investigated using density functional theory (DFT)-based computational methods.
Carbon dioxide biofixation and lipid accumulation potential of an indigenous microalga Scenedesmus obliquus (Turpin) Kützing GA 45 for biodiesel production
Authors: Bagchi Sourav Kumar , Mallick Nirupama
Published: March 2016

A strategy demonstrating the higher potential of Scenedesmus obliquus for CO2 biofixation and biodiesel production under mixotrophy with biphasic nitrogen starvation.
Correction: Removal of safranin-O dye from aqueous solution using modified red mud: kinetics and equilibrium studies
Authors: Sahu Manoj Kumar , Patel Raj Kishore
Published: March 2016

Correction for ‘Removal of safranin-O dye from aqueous solution using modified red mud: kinetics and equilibrium studies’ by Manoj Kumar Sahu et al., RSC Adv., 2015, 5, 78491–78501.
A mercapto functionalized magnetic Zr-MOF by solvent-assisted ligand exchange for Hg2+ removal from water
Authors: Huang Lijin , He Man , Chen Beibei , Hu Bin
Published: March 2016

A facile preparation of magnetic MOF composites with flexible mercapto group pendants in their pores is realized through solvent-assisted ligand exchange (SALE) under mild conditions in water, and terephthalate in UIO-66 is replaced with mercaptoacetic acid (MAA).
Computing pth roots in extended finite fields of prime characteristic p ≥ 2
Authors: Repka M.
Published: March 2016

Direct computation of pth roots in extended finite fields of characteristic p ≥ 2 is introduced, wherein the reduction polynomial is irreducible and can be even random. Proposed method works in any case of p ≥ 2 and finite field extension. This method is the most efficient, it is even more efficient than the method, which is widely used, based on inversion of squaring matrix utilised in the case of p = 2. This method is more efficient regarding the computation and storing of the matrix as well as the computation of the roots.
High‐resolution DOA estimation for cooperation networks using space‐time hopping
Authors: Li Xiangyu , Guo Suxia , Jin Liang , Huang Kaizhi , Xia Lu
Published: March 2016

Since the traditional direction‐of‐arrival (DOA) estimation algorithm is passive and non‐cooperation, its performance degrades with respect to the large number of terminals and closely spaced sources in multi‐nodes networks. A cooperated space‐time hopping algorithm to estimate the DOA of all users simultaneously is presented. The signal will be adjusted by the pre‐assigned hopping weights during each symbol time. The change of the weights is equivalent to the change of array manifolds, thus enriching differences between uses’ channels. This algorithm is able to estimate more number of signals and separate some closely spaced sources. Simulations demonstrate the effectiveness of the algorithm.
Impact of the relay on the coverage region of multiple‐access channels
Authors: Moeen Taghavi Ehsan , Abed Hodtani Ghosheh
Published: March 2016

From practical and theoretical viewpoints, performance analysis of communication systems by using information‐theoretic results is important. In this study, first, the authors obtain a general achievable rate region for three‐user discrete memoryless multiple‐access relay channel (MARC) via partial decode and forward strategy and regular block Markov encoding/backward decoding. Also by extending the discrete alphabet results to the continuous alphabet channel, an inner bound for three‐user Gaussian MARC (GMARC) is achieved. Next, based on the inner bound of three‐user GMARC, they analyse the impact of a relay on the coverage region of MARC, as a basic model for uplink communications between a base station and users with the help of a relay. This analysis includes the coverage region for the multiple‐access channel and two‐user GMARC as special cases. Considering rate regions for the GMARC and fading GMARC, it is proved that in a fixed transmission rate, the relay extends coverage region of the MARC. Numerical illustrations confirm their theoretical results.
Attitude control of quadrotors based on fractional sliding modes: theory and experiments
Authors: Izaguirre‐Espinosa Carlos , Muñoz‐Vázquez Aldo Jonathan , Sánchez‐Orta Anand , Parra‐Vega Vicente , Castillo Pedro
Published: March 2016

Light weight quadrotors are highly manoeuvrable autonomous aerial robots (UAV) that outperform most UAVs; however, quadrotors are prone to a wide class of aerodynamic disturbances, vibrations, and uncertainties that demand not only robust but fast attitude control structures. These arguments are compelling enough to motivate the design of a novel fractional‐order control scheme that enforces finite‐time convergence of the sliding manifold to guarantee local exponential tracking. The controller does not exhibit chattering and does not require the knowledge of the dynamic model. The stability analysis is based on a proposed resetting memory principle to deal with memory effects of the differintegral operator, which allows the controller to tackle also robustness against continuous disturbances that are not necessarily differentiable in the conventional sense such as some aerodynamic phenomena. Experimental evidence is presented and discussed to expose the enforcement of the sliding manifold based on a fractional‐order reaching phase that demonstrates the feasibility of the proposed control scheme.
Straight line matching method based on line pairs and feature points
Authors: Zeng Jiexian , Zhan Liqin , Fu Xiang , Wang Binbin
Published: March 2016

Straight line matching is a fundamental task in many applications such as scene matching, stereo vision and sequence images analysis. As individual line segments cannot completely present the information of image and methods based on them are difficult to achieve high matching accuracy, the authors propose a straight line matching algorithm based on line pairs and feature points. Extracted lines are clustered into line feature sets according to their spatial proximity and geometric structures. The structural relationship between line pairs, which are selected from the line feature sets, is described by feature vector consisting of length ratio, angle and average gradient. Coarse matching of line segments is achieved by using feature vector as similarity measurement. To eliminate the mismatches in the matched straight lines, the constraints of feature points are employed. The experimental results demonstrate that the authors’ algorithm can successfully match image lines with high accuracy under various image transformations, including scale, illumination changes and viewpoint variations.
Minimising disparity in distribution for unsupervised domain adaptation by preserving the local spatial arrangement of data
Authors: Samanta Suranjana , Das Sukhendu
Published: March 2016

Domain adaptation is used for machine learning tasks, when the distribution of the training (obtained from source domain) set differs from that of the testing (referred as target domain) set. In the work presented in this study, the problem of unsupervised domain adaptation is solved using a novel optimisation function to minimise the global and local discrepancies between the transformed source and the target domains. The dissimilarity in data distributions is the major contributor to the global discrepancy between the two domains. The authors propose two techniques to preserve the local structural information of source domain: (i) identify closest pair of instances in source domain and minimise the distances between these pairs of instances after transformation; (ii) preserve the naturally occurring clusters present in source domain during transformation. This cost function and constraints yield a non‐linear optimisation problem, used to estimate the weight matrix. An iterative framework solves the optimisation problem, providing a sub‐optimal solution. Next, using orthogonality constraint, an optimisation task is formulated in the Stiefel manifold. Performance analysis using real‐world datasets show that the proposed methods perform better than a few recently published state‐of‐the‐art methods.
Multi‐directional saliency metric learning for person re‐identification
Authors: Chen Ying , Huo Zhonghua , Hua Chunjian
Published: March 2016

A multi‐directional salience based similarity evaluation for person re‐identification (re‐id) is presented. After distribution analysis for salience consistency between image pairs, a similarity between matched patches is established by weighted fusion of multi‐directional salience. The weight of saliency in each direction is obtained using metric learning by means of structural support vector machines ranking. The discriminative and accurate performance of re‐id is achieved. Compared with existing salience based person matching framework, the proposed method achieves higher re‐id rate with multi‐directional salience based similarity evaluation.
Design and analysis of a novel spoke‐type permanent magnet synchronous motor
Authors: Si Meng , Yu Yang Xiang , Wei Zhao Shi , Gong Sheng
Published: March 2016

This study presents a spoke‐type permanent magnet synchronous motor (STPMSM) with a novel rotor which contains four individual iron core parts with flux barriers that are designed to realise a near‐sinusoidal air gap flux density waveform. This novel type of rotor does not require thin bridges or retaining sleeves, the iron core parts of a rotor of this type are fixed to a non‐magnetic sleeve by using dovetail slots, this structure can restrict flux leakage effectively and ensure sufficient mechanical strength. The initial design parameters of a 3 kW novel motor were obtained in the initial design process first, then several key parameters were optimised by using the Taguchi method, finally a comparative analysis of the novel motor structure and the conventional STPMSM structure was performed. The comparative analysis results reveal that the novel motor structure is superior to the conventional motor structure.
New circuits for emulating switched reluctance motor windings
Authors: Liang Yan , Chen Hao , Shi Jiaotong , Liu Huajian
Published: March 2016

This study sets forth two new universal circuits capable of emulating the behaviour of non‐linear inductance, which are composed of only off‐the‐shelf circuit devices. One of the proposed inductor emulators is dependent on a controllable resistor whose resistance value is programmable, while the other is carried out by using a multiplier to produce the emulator current. The values of the controllable resistance and the input voltage of the multiplier can be easily computed according to the requirement through digital signal processing techniques by means of digital signal processor chip. The phase inductance of switched reluctance motor (SRM) winding is of high non‐linearity due to doubly salient structure and magnetic saturation. Based on the analytical expression of phase inductance, the two proposed universal inductor emulators are applied to mimic the characteristics of SRM windings. The experimental and simulated results of the winding emulators provide the conclusive evidences for validating their practicability. Moreover, the emulators for the whole SRM drive system are designed and the corresponding experimental results further verify the correctness of the proposed SRM winding emulators.
High‐resolution indoor positioning using light emitting diode visible light and camera image sensor
Authors: Kim Jae‐Yoon , Yang Se‐Hoon , Son Yong‐Hwan , Han Sang‐Kook
Published: March 2016

The authors propose a new high‐resolution indoor positioning method based on visible light communication using two light emitting diode (LED) lightings and an image sensor of camera as a receiver. Through the proposed method, the authors can determine position of receiver using the real coordinate of two LED lightings and a captured image. In order to demonstrate the applicability of positioning method, they evaluated the positioning accuracy as changing receiver position. From the experimental results, positioning resolution of maximum 3 cm distance error is demonstrated under the square space with 96 cm height and maximum 6.5 cm distance error under the square space with 245 cm height.
Performance of M ‐ary quadrature amplitude modulation ‐based orthogonal frequency division multiplexing for free space optical transmission
Authors: Jaiswal Ishu , Sangeetha R.G. , Suchetha M.
Published: March 2016

In this study, the authors analyse the performance of the free space optical (FSO) transmission link using orthogonal frequency division multiplexing (OFDM) modulation with M ‐ary quadrature amplitude modulation (QAM) encoder. For strong and weak atmospheric attenuation, the analysis of channel distribution in FSO is carried out using gamma–gamma model. In this analysis, the expressions for probability density function and cumulative density function of OFDM‐based FSO channel have been derived in terms of Meijer's G‐function. Also, the bit error rate and outage probability of M ‐ary QAM‐based OFDM for an FSO transmission link has been derived. The feasibility of the system and the derived expressions are verified using Opti‐system and MATLAB. From the analysis, it is observed that the performance of OFDM using M ‐ary QAM modulation is feasible for 7000 m, owning to its simplicity and good performance.
Zero circulating current modulation for isolated bidirectional dual‐active‐bridge DC–DC converter
Authors: Karthikeyan V. , Gupta Rajesh
Published: March 2016

In this study, a zero circulating current (ZCC) modulation technique is proposed for isolated bidirectional DC–DC converter (IBDC). The operating modes of the proposed modulation technique for the bidirectional dual active bridge DC–DC converter have been discussed and analysed. The proposed ZCC modulation not only reduces the current stress but it also eliminates the circulating power flow (CPF). In forward mode, the fixed 50% duty cycle and pulse width modulation signals are applied to the high voltage and low voltage bridges of IBDC converter, respectively. In reverse mode, the switching pattern is interchanged to reverse the power flow. The rising and falling edge phase‐shift ratios are introduced for the two waveforms which help in identification of the ZCC switching. Condition on falling edge phase‐shift ratio is determined to eliminate the CPF in the IBDC. This study also addresses the impact of the CPF on performance of the IBDC. The simulation and experimental results validate the proposed ZCC modulation for the IBDC.
Operation method for input‐series‐output‐parallel AC–DC–DC converter
Authors: Song Chunwei , Guo Yonghong , Zeng Zheng , Sun Lihong , He Jinlong , Li Mei
Published: March 2016

In this study, the proposed configuration of input‐series‐output‐parallel (ISOP) AC–DC–DC converter consists of a cascaded H‐bridge (CHB) rectifier in the AC/DC stage and a parallel DC–DC converter in the DC/DC stage. This study reveals the relationship between input voltage sharing (IVS) and output current sharing (OCS) among the constituent modules. The factors causing DC‐link voltage unbalance among series units in CHB rectifier are studied in detail. With the proposed operation method, the power balance including IVS, DC‐link voltage balance and OCS can be achieved. In addition, the converter can always operate under a unity power factor with low‐distortion grid current. The experimental results are presented to demonstrate the validity and features of the proposed operation method.
Fuzzy logic controller for partial shaded photovoltaic array fed modular multilevel converter
Authors: Guruambeth Ramya , Ramabadran Ramaprabha
Published: March 2016

This study presents the control and modelling of modular multilevel converter (MMC) with grid‐connected photovoltaic system. Synchronisation is an important issue in grid‐connected system. Even though conventional proportional–integral (PI) controller used for synchronisation provides adequate performance, it yields poor transient response of the system because of poor tuning of controller gain values. In this study, the fuzzy tuned PI controller is designed and implemented to overcome this problem. The fuzzy logic controller refrains the controller gains based on the operating point of the system. The improved performance parameters such as faster transient response, tracking of the reference current with low overshoot and short settling time with system parameter changes under partial shading of the proposed controller are validated. The results are compared with conventional PI controlled grid‐connected MMC with various PI gains. The developed controller algorithm is implemented through TMS320F28335 digital signal processor.
Galvanically isolated modular converter
Authors: Christe Alexandre , Dujic Drazen
Published: March 2016

Direct current (DC) electrical grids are already a reality in low voltage (LV) telecom distribution systems and point‐to‐point high voltage DC transmission. Medium voltage (MV) domain, despite its big potential, still suffers from a lack of suitable conversion and protection technologies. This study presents a bidirectional, galvanically isolated, high power converter for interface of emerging MVDC grids with readily available LVAC grids. To achieve high conversion efficiency, the integration of a line frequency transformer into the structure of the modular multilevel converter (MMC) is analysed and described in a systematic manner. Two configurations of the galvanically isolated modular converter: (i) interleaved and (ii) stacked, are derived and presented. Differences and similarities, compared to the classical MMC, are presented on the system design level, while control performances are evaluated by means of simulations.
Poly(N ‐isopropylacrylamide)/polyurethane core–sheath nanofibres by coaxial electrospinning for drug controlled release
Authors: Lin Xiuling , Tang Dongyan , Lyu Haitao , Zhang Qingnan
Published: March 2016

A new type of drug carrier with thermo‐sensitivity is reported. The system consisted of poly(N ‐isopropylacrylamide) (PNIPAAm) and polyurethane (PU) and two kinds of polymer were spun into core–sheath nanofibres without bead defects by coaxial electrospinning technique. Poor soluble nifedipine was used as a model drug to evaluate the release behaviour of drug from nanofibre carriers. Results showed that the diameter and diameter distribution of nanofibres varied with the ratios of the outer flow rate to the inner flow rate. PNIPAAm/PU core–sheath electrospun nanofibres maintained the thermo‐sensitivity of PNIPAAm and the wettability of the electrospun nanofibres could be adjusted effectively by the change of the temperature. In‐vitro release of nifedipine from nanofibre carriers showed that core–sheath electrospun nanofibres as the drug carrier could slow down the release rate of nifedipine compared with that of PNIPAAm/PU composite electrospun nanofibres, and then could effectively achieve the controlled release of nifedipine, avoiding the concentrated release of drug and reduce the toxicity.
Nitrate sensing based on Pd‐Sn bimetallic composite: a comparison between a bulk electrode and a microband electrode array
Authors: Fu Yexiang , Bian Chao , Kuang Jian , Li Yang , Xia Shanghong
Published: March 2016

This work presents a bulk electrode and a microband electrode array for electrochemical nitrate sensing in acidic medium. The microelectrode array is fabricated on silicon wafer by micro electro‐mechanical system technique. Electrodepostion was carried out to modify tin onto the bulk palladium electrode and thus formed Pd‐Sn bimetallic composite. On the microelectrode array, Pd and Sn were successively deposited to obtain a double‐layer composite. The performance of the two kinds of electrodes towards nitrate sensing was investigated and compared. The microelectrode array showed better sensitivity and repeatability than the bulk electrode. The results are consistent with the unique properties of the microelectrode array in electrochemical analysis such as high current density and low background noise.
„Gewehr bei Fuß“, Interview mit Dr. Axel Paeger in der kma 4/2012
Authors: kma-Redaktion Die
Published: March 2016

In dem genannten Beitrag mit dem Vorstandsvorsitzenden Dr. Axel Paeger wird die AMEOS Gruppe als „Konzern“ bezeichnet.
Nicht zwingend ein Widerspruch
Authors: Zehnder Adalbert
Published: March 2016

Hohe Qualität? Oder niedriger Preis? Beides gar? Auf einer der 150 Fachveranstaltungen auf dem Hauptstadtkongress im Juni in Berlin werden Experten von Leistungserbringern und Krankenkassen lebhaft über die Frage debattieren, was Krankenhäuser realistischerweise leisten können.
Kopfschmerzen durch Pharmapreise
Authors: Doelfs Guntram
Published: March 2016

Unikliniken klagen über einen rasanten Anstieg der Preise für patentgeschützte Medikamente. Offenbar nutzen Pharmafirmen den stationären Markt, um ihre Verluste durch Rabattierungen im ambulanten Bereich auszugleichen.
Gemeinsame Sache
Authors: Petzsch Sandra
Published: March 2016

Die Idee, verschiedene Bildgebungsverfahren miteinander zu koppeln, bestimmt zunehmend die Entwicklungen der Hersteller.
Protest gegen die Aufräumarbeiten
Authors: Mau Jens
Published: March 2016

Siemens hat es nicht geschafft, die Partikeltherapie in die klinische Breitenversorgung zu bringen, und dafür viel Lehrgeld bezahlt. Die Anlage in Kiel wird bereits abgebaut. Die Deutsche Gesellschaft für Radioonkologie warnt nun, dass Marburg das gleiche Schicksal ereilen könnte.
„Eingeschränkte Aussagekraft“
Authors: Mau Jens
Published: March 2016

Qualitätsberater Sebastian Irps bewertet die Fallzahlenstudie von Thomas Mansky positiv, bemängelt aber, dass der Schwerpunkt auf der Mortalität liegt.
Helferlein im Hintergrund
Authors: Dirks Claudia
Published: March 2016

Wer heute in Deutschland vom papierlosen Krankenhaus spricht, beschreibt nicht den Alltag. In den meisten Kliniken existieren Papier und digitale Welt nebeneinander, und die Mitarbeiter müssen sich mit Medienbrüchen arrangieren. Dokumenten-Management-Systeme verbinden diese Parallelwelten zumindest teilweise. So tragen sie dazu bei, Betriebsabläufe effizienter zu gestalten und die Zahlen im Blick zu halten. Ganz nebenbei sorgen sie auch für eine enorme Platzersparnis.
Lösung für den Datendschungel
Authors: Dirks Claudia
Published: March 2016

Das Klinikum Stuttgart hat es nach einem Jahr Pause wieder unter die „IT-Schlüssel-Themen“ des Entscheiderfabrik-Wettbewerbs geschafft. Mit Vivantes Berlin, Hewlett Packard und Synagon tritt es an, ein Lösungspapier dafür zu konzeptionieren, wie Kliniken der Flut an elektronischen Daten zukunfts- und investitionssicher gegenübertreten können. Kein leichtes Unterfangen.
Im Fadenkreuz
Authors: König Romy
Published: March 2016

Zur Aufdeckung von Korruption und Betrug dürfen die Kassen jetzt personenbezogene Daten untereinander austauschen. Kluge Kliniken beugen vor und professionalisieren ihre Compliance-Abteilungen – indem sie etwa ein Regelwerk aufsetzen und ihre Mitarbeiter auf Compliance-Schulungen schicken.
Den größeren Handlungsrahmen nutzen
Authors: Thalmayr Maria
Published: March 2016

Verbandsnachrichten der FKT - Fachvereinigung Krankenhaustechnik (e. V.). Diese Seiten sind nur als PDF-Dokument verfügbar.
Willkommen in der Medizin
Authors: Gaede Kirsten
Published: March 2016

Die Quotendiskussion steht jetzt auch den Kliniken ins Haus. Ob sie wollen oder nicht: Namhafte Ärztinnen und Wissenschaftlerinnen haben sich in der Initiative „Pro Quote in der Medizin” zusammengeschlossen und einen offenen Brief an Verbände, Gesellschaften und Kliniken geschickt.
Deutscher Pflegerat bläst zum Wahlkampf
Authors: Gaede Kirsten
Published: March 2016

Mit einer großen Kampagne vor der Bundestagswahl will der DPR auf die Ausdünnung der Pflege in den Kliniken aufmerksam machen. Er hofft auf Unterstützung von Industrie und Krankenkassen. Zum Auftakt hat der Deutsche Pflegerat kürzlich einen offenen Brief an Bundeskanzlerin Angela Merkel geschickt.
Worms spart Putzmittel
Authors: Mau Jens
Published: March 2016

Das Klinikum Worms hat als bisher einzige Klinik in Deutschland das Chemikalien-Leasing eingeführt und nun erstmals Ergebnisse veröffentlicht.
Willkommener Tabubruch
Authors: Gaede Kirsten
Published: March 2016

Zeitarbeit oder Leiharbeit – so etwas kennen die meisten Ärzte nur von ihren Patienten. Doch diese viel geschmähte Beschäftigungsart hält jetzt Einzug in die Medizin: weil sie Kliniken und Ärzten mehr Sicherheit bietet als Honorartätigkeit.
Königin des Einkaufs
Authors: Gaede Kirsten
Published: March 2016

Bestellungen mit Durchschlag, Lagerregale ohne Kennzeichnung – es herrschte Chaos in der Einkaufsabteilung der Uniklinik Bonn. Bis die Von-Eiff-Schülerin Kerstin Stachel kam. Das Bundeswirtschafts-ministerium hat die zupackende Geschäftsbereichsleiterin und ihre Mitarbeiter jetzt sogar mit einem Preis für ihre innovativen Beschaffungsprozesse ausgezeichnet.