bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Geometries and Vibrational Contributions to Reaction Thermochemistry Are Surprisingly Insensitive to Choice of Basis Set
Authors: He Xinlan , Wang Minzhi , Lorpaiboon Wanutcha , Mun Haedam , Taylor Mackenzie , Ho Junming
Published: April 2023

Calculation of molecular geometries and harmonic vibrational frequencies are pre-requisites for thermochemistry calculations. Contrary to conventional wisdom, this paper demonstrates that quantum chemical predictions of the thermochemistry of many chemical reactions appear to be very insensitive to the choice of basis sets. For a large test set of 80 diverse organic and transition-metal containing reactions, variations in reaction free energy based on geometries and frequencies calculated using a variety of double and triple-zeta basis sets from the Pople, Jensen, Ahlrichs and Dunning families are typically less than 4 kJ mol-1, especially when the quasiharmonic oscillator correction is applied to mitigate the effects of low-frequency modes. Our analysis indicates that for many organic molecules and their transition states, high-level rev-DSD-PBEP86-D4 and DLPNO-CCSD(T)/(aug-)cc-pVTZ single point energies usually vary by less than 2 kJ mol-1 on DFT geometries optimised using basis sets ranging from 6-31+G(d) to aug-pc-seg-2 and aug-cc-pVTZ. In cases where these single-point energies vary significantly, indicating sensitivity of molecular geometries to choice of basis set, there is often substantial cancellation of errors when the reaction energy or barrier is calculated. The study concludes that the choice of basis set for molecular geometry and frequencies, particularly hose considered in this study, is not critical for the accuracy of thermochemistry calculations.
Computational Insights into the Interaction of Water with the UiO-66 Metal-Organic Framework and Its Functionalized Derivatives
Authors: Zhang Jierui , Paesani Francesco , Lessio Martina
Published: April 2023

The UiO-66 metal-organic framework (MOF) has been identified as a promising hydrophilic material for water harvesting. Recent studies show that its water uptake ability at low relative humidity (RH) can be improved by incorporating hydrophilic functional groups into the framework. In this work, we provide computational insights into the adsorption of water in UiO-66 and its functionalized derivatives to reveal the role played by different adsorption sites and functional groups in the adsorption mechanism. We started by developing molecular models for UiO-66, UiO-66-NH2, UiO-66-OH, and UiO-66-(OH)2 compatible with the MB-pol data-driven many-body potential of water. We then benchmarked these models against ab initio data. We used these models to perform molecular dynamics simulations and calculate radial distribution functions, IR spectra, and two-dimensional density distribution maps for water in the MOFs. These results consistently show that the μ3-OH sites are the preferential interaction sites for water in UiO-66 and all its variants, and the formation of localised water clusters inside the octahedral pores is responsible for the abrupt step in the experimental adsorption isotherms. Furthermore, the presence of functional groups in the framework allows water to cluster in the octahedral pores at lower RH, thus making the MOF a more efficient water harvester. Overall, this study provides molecular-level insights into the pore filling process of UiO-66 and its functionalized derivatives, which are needed for the design of efficient water harvesting materials based on MOFs.
Effect of bankruptcy costs on value of firms listed in Nairobi securities exchange
Authors: C P A Dennis Nyamasege
Published: April 2023

This study measured the effect of bankruptcy costs on the value of the firm . Financial statements of listed firms for the period of 10 years 2008- 2017 were used. The study was anchored on the Traditional theory which emphasizes on optimality of a capital structure. This study was guided by positivisim research philosophy due to its power of applting deductive logic in arriving at meanings. Asample of 40 firms which have been consistently quoted during the entire study period of 2008-2017 was used. A data collection sheet was used to extract secondary data from published financial statements. Peer reviews were done to unsure face validity while expert opinion ensured content validity. Data was analyzed using descriptive statistical methods of minimums, maximums, mean, percentages and standard deviation. Further Karl Pearson correlation coefficient and backward regression techniques were adopted in analysing the panel data. The results were presented in the form of summarised tables and graphs. The findings revealed bankruptcy costs and had significant effect on value of the firms listed in Nairobi Securities Exchage. It was recommended that information symmetry could be enhanced through close monitoring of compliance to corporate governance practices particularly on disclosure requirements.
Analyzing game-streaming services in two-sided markets: Direct selling and cloud alliance models
Authors: Jhih-Hua Jhang-Li  , Jyh-Hwa Liou
Published: April 2023

This study analyzes the profit of a cloud console provider facing competition from a hardware console provider in a two-sided market composed of game developers and consumers. The cloud console provider can either sell its subscription package to consumers independently or organize a cloud alliance with an ISP to market. As compared with the direct selling model, the cloud alliance model with full coordination can yield greater total revenue if the benefit the game developers receive from the consumer side is higher than the value the consumers receive from the developer side. However, the overall profit of the cloud alliance declines when this condition is reversed. This undesired result can be resolved by leveraging the game-streaming subscriber base to yield a moderate amount of additional revenue for the cloud console provider.
Relationship between availability of multimedia instructional technologies and training of office technology and management (otm) students for entrepreneurship in polytechnics in south-east; Nigeria
Authors: C M Ile , Okonkwo  , Dyke Amarachukwu Remigius
Published: April 2023

This paper investigated the availability of multimedia instructional technologies for entrepreneurship training of Office Technology and Management (OTM) students of polytechnics in South-East Nigeria. One research question was posed and one corresponding null hypothesis formulated for testing at 0.05 level of significance.Descriptive survey research design was adopted for the study and 86 Office Technology and Management (OTM) lecturers in both Federal- and State-owned polytechnics in South-East, Nigeria that offer entrepreneurship courses were studied without sampling. A structured questionnaire was used for data collection. The reliability of the instrument was established though trial-testing and calculation using Cronbach alpha method that yielded a correlation coefficient of 0.78. Data collected were analyzed using frequency count and percentages, mean, standard deviation, Chi-square and t-test. The results showed that majority (56%) of multimedia instructional technologies were not available in OTM departments for entrepreneurship training of OTM students. The findings also revealed that ownership of the institutions was not a significant factor on the availability of audio, visual and audio-visual instructional technologies for entrepreneurship training of OTM students in polytechnics in South-East Nigeria. Based on the findings, the researcher concluded that OTM students in polytechnics in South East Nigeria were taught entrepreneurship without necessary and required multimedia instructional technologies and this affected their entrepreneurship success upon graduation. It was recommended among others that Federal and State governments should support polytechnics in Nigeria to procure multimedia instructional technologies since their acquisition is cost intensive and cannot be procured by OTM Departments of the institutions.
De sujetos de poder a sujetos de saber: una lectura arqueológica de la idea de infancia en Colombia
Authors: Mesa Leidy Ximena , Garzón Borray Helen Alexandra , Vargas Orjuela Margy Paola
Published: April 2023

El presente capítulo se orienta a reflexionar el papel del niño y la niña como un sujeto activo en sus procesos de formación, pero, además, que intenta adentrarse a los escenarios políticos dejando de lado la representación social del niño como un “objeto” de cuidado, intervención y protección por parte de un adulto “responsable”. Es por esto que se asume la necesidad de reconocer inicialmente el origen de la concepción de infancia desde dos escenarios legitimados socialmente: la escuela y la familia. Instituciones con mayor fuerza en la sociedad, pero además bajo la tutela de la ideología eclesiástica que encontró en la infancia el medio para mantener su statu quo.
Banca Multilateral y Unión Europea: iniciativas en torno al conflicto armado en Colombia
Authors: López-Rodríguez Campo Elías , García Cárdenas Mónica Lizeth , Ortiz Patiño Camilo Andrés
Published: April 2023

El libro de investigación “Banca Multilateral y Unión Europea: iniciativas en torno al conflicto armado en Colombia” resalta el protagonismo que podría tener la Banca Multilateral en el fortalecimiento del fondo fiduciario para la paz de la Unión Europea, al cual apalanca la sostenibilidad de proyectos productivos en la población afectada por el conflicto armado colombiano. Por lo anterior, se hace pertinente establecer las diferentes contribuciones que la Banca Multilateral ha hecho en pro del desarrollo económico en desarrollo de América Latina, así como también caracterizar los proyectos aprobados por la Unión Europea para la ejecución de recursos del Fondo Fiduciario para la paz, lo anterior con un solo propósito: visualizar una posible articulación entre la Banca Multilateral y la Unión Europea para el fortalecimiento y sostenibilidad de los proyectos productivos desde el apalancamiento financiero, de tal forma que este ejercicio pueda ser aplicado en la implementación de Programas de Desarrollo con Enfoque Territorial (PDET). The current research book “multilateral bank and European Union: Proposals around Colombia´s armed conflict”, highlights the protagonist the field could have strengthened the Peace European´s Union fiduciary fund which leverages the sustainability of productive projects within the population affected by the Colombians armed conflict. Is important to stablish the different contributions the multilateral bank has done in favor of economic development of Latin America, as to characterize the projects approved by the European Union for the disbursement of resources of the fiduciary peace fund with one main aim: to visualize a possible articulation between the Multilateral bank and the European Union for strengthening and leverage the productive projects derived from strategy Programs of Development with territorial focus (PDTF) (Programas de Desarrollo con Enfoque Territorial (PDET))
Freies Ermessen Dalam Tindakan Nyata di Pemerintah Daerah
Authors: Fasyehhudin Mohamad
Published: April 2023

This study aims to examine the authority of regional government agencies/officials in implementing Freies Ermessen in regional policies and the binding power of Freies Ermessen as legal provisions in the regions. The novelty of this research is to analyze the application of Freies Ermessen in regional policies. This study uses a normative juridical approach. The results of this study are the use of Freies Ermessen Government Officials to expedite government administration, fill legal voids, provide legal certainty, overcome government stagnation in certain circumstances for the benefit and public interest. In implementing the Freies Ermessen Decree as a legal policy in the region, UUAP government agencies/officials are prohibited from abusing authority, which includes prohibitions on exceeding authority, mixing authority and not acting arbitrarily so that discretionary policies have binding power as legal decisions.

  

Penelitian ini bertujuan untuk mengkaji mengenai kewenangan badan/pejabat pemerintahan daerah dalam penerapan Freies Ermessen dalam kebijakan di daerah serta kekuatan mengikat Freies Ermessen sebagai ketetapan hukum di daerah. Kebaharuan penelitian ini adalah untuk menganalisis penerapan Freies Ermessen dalam kebijakan di daerah. Penelitian ini menggunakan pendekatan yuridis normatif. Hasil penelitian ini adalah penggunaan Freies Ermessen Pejabat Pemerintahan diterapkan untuk melancarkan penyelenggaraan pemerintahan, mengisi kekosongan hukum, memberikan kepastian hukum, mengatasi stagnasi pemerintahan dalam keadaan tertentu guna kemanfaatan dan kepentingan umum. Dalam melaksanakan Keputusan Freies Ermessen sebagai kebijakan hukum di daerah, badan/pejabat pemerintahan UUAP dilarang menyalahgunakan wewenang, yang meliputi larangan melampaui wewenang, mencampuradukan wewenang dan dilarang bertindak sewenang-wenang agar kebijakan diskresi memiliki kekuatan mengikat sebagai keputusan hukum                                                                                                                                            

  

  

  

  

  

  
Engelli Kadın Sporcuların Toplumsal Deneyimleri Üzerine Bir Çalışma (A Study on The Social Experiences of Disabled Woman Athletes)
Authors: Bayındır Zeynep , Tuna Uysal Meryem
Published: April 2023

Bu araştırmada engelli sporlarında kadınların yaşadıkları avantaj ve dezavantaj durumlarını, sporun toplumsal cinsiyet rolleri üzerindeki etkisini, sporun içindeki toplumsal cinsiyet eşitsizliklerini anlamak ve betimlemek hedeflenmiştir. Araştırma yedi farklı hem bireysel hem de takım sporlarında profesyonel olarak spor yapan faal paralimpik kadın sporcuların toplumsal ve spor hayatlarındaki deneyimlerini içermektedir. Buna göre araştırmada engelli kadın sporcuların spor ve toplumsal hayatın diğer alanlarını anlamaya yönelik betimleyici bir analiz sunmayı hedeflediği için nitel araştırma yöntem ve teknikleri kullanılmıştır. Araştırmaya katılan 17 kadın engelli sporcuya kartopu örneklem tekniği kullanılarak ulaşılmıştır. Araştırma sonucunda engelli kadınların hem “normallik” hem “sağlamlık” normlarının dışında kabul edilerek spor alanından dışlandığı spora daha az teşvik edilmesinde toplumsal cinsiyet eşitsizliklerinin etkili olduğu görülmektedir. Bu makale Doç. Dr. Meyrem TUNA UYSAL danışmanlığında Zeynep BAYINDIR tarafından hazırlanan yüksek lisans tez çalışmasının verilerinden yararlanılarak üretilmiştir.
Dil Bilimci Cevdet Nasuhi Savran ın Yeni Bilgilere veya Belgelere Göre Hayatı, Eserleri ve Öz Türkçeciliği (According To the New Information or Documentation of The Linguist Cevdet Nasuhi Savran, His Life, Works and His Own Turkish Language)
Authors: Eraslan Ebubekir
Published: April 2023

Cevdet Nasuhi Savran; ilk ve orta öğrenimini Türkiye’de tamamladıktan sonra yüksek öğrenimini bitirmek üzere İsviçre’ye gitmiştir. İsviçre’de tıp eğitimini alırken Jön Türk hareketinin İsviçre’deki temsilciliğini yapmış, kurulan cemiyetlerin tek çatı altında toplanmasını sağl amış, İsviçre’de Türk lobiciliğinin kurumsallaşmasında önemli hizmetlerde bulunmuş, Balkan Savaşı çıktığı zaman tereddüt etmeden Türkiye’ye gelmiş ve Mehmetçik’in destekçisi olmuş, savaşların bitiminde Türkiye’nin ilk psikiyatristlerinden birisi olarak yurduna dönmüştür. Savran; Türkiye’de hem Darülfunun’da hem de farklı hastanelerde ve birimlerde Cumhuriyet kuruluna kadar çalışmıştır. Ayrıca farklı kurum ve kuruluşlarda kooperatifçilik, bankacılık ve psikoloji derslerini vermiş; yazdığı kitaplar, makaleler ve verdiği konferanslarla Türkiye’de kooperatifçilik alanında farkındalık oluşmasına gayret etmiştir. Cevdet Nasuhi Savran, bilinçli olarak özellikle 1925 yılından itibaren anlaşılır bir Türkçeyle yazı yazmaya çalışmış, Birinci Türk Dil Kurultay’ında gönüllü üye olmuş, sonrasında Dil Kurumu bünyesinde kurulan farklı terim komisyonlarında çalışmış, Türk Dil Kurumu’nun üyesi olmuş, öz Türkçeciliğe yönelerek hem uygulamalı hem de teorik olarak Türkçeye hizmet etmiş bir dil bilimcidir.
Anais do III Simpósio de Ginecologia e Obstetrícia do Delta do Parnaíba
Authors: Santos Livia Rocha , Moraes Guilherme Augusto Silva de
Published: April 2023

O Simpósio de Ginecologia e Obstetrícia do Delta do Parnaíba é um evento realizado pela Liga Acadêmica de Ginecologia e Obstetrícia da Universidade Federal do Delta do Parnaíba-LIAGO, o evento é realizado bianualmente, com o objetivo de disseminar e incentivar as discussões pertinentes em torno dos assuntos das áreas de ginecologia e obstetrícia. O evento contribui e incentiva para a formação acadêmica dos estudantes da área da saúde. Em sua terceira edição, após ser adiado, por conta da pandemia da COVID-19, foi realizado em presencial em Parnaíba, Piauí, com o tema “ Vivenciando a ginecologia e Obstetrícia”, teve uma abordagem multidisciplinar, contou com palestrantes nomeados da região do Delta do Parnaíba para discutir e expor os assuntos mais relevantes e atuais sobre a saúde da mulher. Além disso, o evento contou com o edital para submissões de trabalhos acadêmicos, no intuito de estimular e valorizar as pesquisas realizadas acerca da saúde da mulher.
In the Clearing
Authors: Hardy Billy
Published: April 2023

Some context
I brought these words together in 2022 following a weekend I spent with my younger sister, Annemarie, and my younger brother, James, who came to visit me together, something that hadn’t happened before and I was left humbled by their visit.
The conversations we created as the remaining elder generation of our family were moving and it was the first time such conversations took place. The context for this coming together was triggered by a chemotherapy treatment phase following my recent diagnosis of cancer.
This weekend became an important event in our lives thus far, and as I was exploring poetry as an antidote to patient-hood, as well as making my voice find its relationship to myself inhabited by cancer, I try to capture our conversations and share them with you here.
My sister and brother have given me permission to publish this. I honour them as “us” and our experiences we have shared.
The Construction of Meaning in Three Fairy Tale Enhanced Electronic Picturebooks
Authors: Frederico Aline
Published: April 2023

Informed by David Lewis’ ecological approach to picturebooks, this study conducted close readings of three enhanced e-book versions of the fairy tale The Three Little Pigs, analyzing how the different modalities that constitute these narratives interanimate each other and participates in the meaning-making process.Fondée sur l'approche écologique du livre d'images de David Lewis, cette étude repose sur une lecture attentive de trois éditions numériques au contenu rehaussé du conte de fées Les trois petits cochons. L'analyse s'intéresse aux différentes modalités qui constituent la trame narrative et qui s'animent entre elles tout en contribuant au processus de création de sens.
A Brief Review of the Monkeypox Outbreak: Transmission, Presentation, and Developments in Treatment and Vaccines
Authors: Elahi Aria , Alan Maddox Parker , Khuram Hassan , Lewis Joshua , Hirani Rahim
Published: April 2023

The medical response to monkeypox(mpox) is a key demonstration of how COVID-19 remodeled the global response to viruses in the medical field. As a result of the 2019 pandemic, the 2022 mpox outbreak was met with mass production of vaccines, widely available PCR testing, and increased public health and research efforts. Easy access to vaccines such as the ACAM2000 and the JYNNEOS vaccines bolstered prevention while antivirals alleviated symptoms and shortened viral duration in at-risk patients. Various methods of detection have been developed for mpox over a short period with PCR currently being used in an attempt to isolate specific strains of the virus. In this brief review, we discuss its classical presentation, and detection and treatment strategies adapted to mitigate this public health risk.
Induction of plasmacytoma in mice and establishment of continuous cell line that lack Retinoblastoma gene expression
Authors: Al-Shamery Ahmed M. , Nahi Y. Yaseen  , Shalal M. Hussien  , Aymen A. Hassan  , Aesar A. Ahmed
Published: April 2023

The pristane oil induced mouse plasmacytoma (MPC) model is the most widely used and accepted model and has provided the most data on plasmacytomagenesis so far. Plasmacytoma were induced in Swiss mice by the intraperitoneal injection of pristane (2,6,10,14-tetra-methylpentadecane) after a latent period of 5-6 months where the mice developed ascites tumors. Aspirated cells were cultured in tissue culture flasks and kept under observation and further passaged to obtain continues cell line. Peritoneal exudate cells were prepared from pristane-treated and control uninjected mice during the course of a 6-month period, and these cell suspensions were studied by means of cytology, histology and Immunohistochemistry methods to identify the plasmacytoma specific markers and the genetic changes. Results showed induction of the tumor in 50% of injected mice and the new cultured cell line were negative for Retinoblastoma (RB) and epidermal growth factor receptor (EGFR)
Writing scientific theses/dissertations in biology field: confusing in using abstract and summary term
Authors: Yaseen Nahi Y.
Published: April 2023

Writing the abstract in a thesis, a dissertation and in a scientific paper is of a great importance to condense the contents in well readable and self expressible short text. The abstract should give a real, precise, accurate and satisfied picture for the entire scientific article. Two terms (abstract and summary) were used widely by Iraqi biological sciences postgraduate students as the first chapter in their theses and dissertations writing. These both terms usually are different in their context writing style and in their content. It is supposed that abstract should be used in the writing of scientific articles, thesis or dissertation instead of summary. This study hypothesized that those students have no knowledge and skill to differentiate between abstract and summary terms in their writing process. This study involved reading and analyzing of 124 thesis and dissertations from different biological disciplines and involved also interviewing 114 postgraduate students to uncover the accuracy of using those two terms and to have proper idea about their knowledge in abstract writing guidelines. The results revealed that most students didn’t differentiate between abstract and summary in their writing, no abstract was written correctly indicating that the students lacked the knowledge and skill of abstract writing guidelines. The students did write their abstract by blindly mimic the previous students writing style without any attempt to check the accuracy of writing process. Reconsideration for postgraduate students’ syllabus must be taken to establish rigid system for scientific writing based on international guidelines.
Detection of DNA H.pylori and distribution of CagA genotype in cancerous and precancerous tissue
Authors: Bakir Wasan A.
Published: April 2023

Helicobacter pylori (H. pylori) has been recognized as the causative agent of chronic gastric inflammation, which can progress further to a variety of diseases such as peptic ulcer and adenocarcinoma. The major bacterial virulence markers of H. pylori, the cytotoxin-associated gene (CagA), may play a role in determining the clinical outcome of Helicobacter infections. Aim of this study to investigate the presence of H.pylori DNA within gastric epithelial cells in patients with H.pylori infection and to determine the prevalence of CagA among patients with cancerous and precancerous lesion. Methods: A total of 92 gastric biopsy samples, 25 H.pylori negative and 67 H.pylori positive patients. H.pylori DNA in gastric epithelial cells and CagA gene of H. pylori was assessed by using the in situ hybridization test. Results: In H. pylori positive group, the positive rates of H.pylori DNA in the gastric epithelial cells were progressively increased in chronic superficial gastritis, precancerous changes and gastric cancer groups(P>0.01); The detection of CagA positive H. pylori was significantly higher in patients with gastric cancer compared to those with chronic superficial gastritis and atrophic gastritis(P<0.01). Conclusion: The pathological progression from chronic superficial gastritis, precancerous changes to gastric cancer is associated with higher positive rates of H.pylori DNA presence in the gastric epithelial cells, and there was a significant increase in CagA-positive H.pylori among patients with gastric cancer
Convolvulus Scammonia crude Alkaloids extract induces apoptosis through microtubules destruction in mice hepatoma H22 cell line
Authors: Tawfeeq Amer T.
Published: April 2023

This study evaluated the ability of crude alkaloids extracted from the leaves of Convolvulus Scammonia to distract the microtubule network of mice hepatocarcinoma cell line (H22), which is an invasive metastasis cell line. This assessment was carried out using the immunostaining technique. The extract was able to distract the microtubules of the cells under investigation after 60 min of exposure in a concentration as little as 20 µg/ml. when DAPI staining used, the cells apoptosis was not detected in this concentration and time. The apoptotic cell have been observed when the concentration of the alkaloid extract elevated up to 80 and 100 µg/ml during the mentioned exposure time. The cells were capable of recovering there native microtubules constriction after 12 hr of the alkaloid removal from the media. The extract concentration of 1mg/Kg/Bw efficiently inhibited H22 cell line tumor growth in vivo to 97.14% in mice after three weeks treatment compared to untreated control animals
Isochromosome 6(p) is a rare chromosomal aberration in Acute Lymphoblastic Leukemia: A case report
Authors: Ismail Noor Hashim
Published: April 2023

Cytogenetic analysis using G- banding technique was performed on bone marrow cells from a 22-year-old female who was diagnosed with Acute Lymphoblastic Leukemia . The chromosomal analysis showed a complex karyotype which included the Isochromosome 6(p) in 16 metaphases (16%) of 97 total metaphases studied . This finding suggests a strong selective pressure for loss of heterozygosity of genes located on 6q , and is in keeping with the hypothesis that one or more tumor suppressor genes might be located on the long arm of chromosome 6 . Moreover, trisomy (or tebasomy) for the short arm of chromosome 6, due to the isochromosome formation , indicating also a possible role for amplification of genes located on 6p in tumor progression in this case of acute lymphoblastic leukemia
Effect of In-vitroSperm Activation Techniques and Albumin Concentrations on Human Sperm Parameters and Chromatin Structure
Authors: Nasser Nadia N.
Published: April 2023

Current study used the acridine orange test to investigate the effect of two techniques of human sperm preparation involved direct swim up technique and centrifugation swim up technique on the integrity of sperm chromatin structure, and also the supplementation of two concentrations of Human serum albumin (HSA) in the culture medium that has been used in the previously mentioned methods. Assay results demonstrated that, both techniques reduce the percentages of isolated or activated spermatozoa with fragmented DNA as compared with their percentages pre-preparation, whither this decrement was significant or not (P=0.05). Also we found that using culture medium supplemented with concentrations of HSAenhance the isolation of spermatozoa with intact DNA, and (10%)HSA was the better.Therefore, the present study concluded that neither direct swim up nor centrifugation swim up techniques with single centrifuge step (559g) for 8minutes can cause further DNA damage in the activated spermatozoa by both, also the involvement of HSA in sperm preparation media enhances sperm parameters and the isolation of spermatozoa with intact DNA in-vitro.
Correlation Between Tumor Suppressor Gene P53 In Some Iraqi Patients With Thyroid Carcinoma By Immunohistochemical Assay and In Situ hybridization Method
Authors: Galoub Abd-Alameer N.
Published: April 2023

The present study was designed to compare between two methods (Immunohistochemistry and In Situ hybridization ) to investigate the relationshipe between tumor suppressor gene (P53) in some samples of some Iraqi patients with thyroid tissue cancer from different site (papillary, follicular and lymph node). A series of 30 patients with thyroid cancer who had undergone thyroidectomy. All these samples were collected during (2011-2012) . The histologic types included 21 well differentiated papillary , follicular and lymph node carcinomas,and nine poorly differentiated carcinomas.By using Immunohistochemistry , P53 was detected in eighteen out of thirty (60%) , whereas at In Situ hybridization , it was detected in fourteen out of thirty (46.6%), Moreover the positive results of the tumor supprewwor gene (p53) was related in highly significant to each of age, gender, stage and histologic grade of tumor.It is conclude from that immunohistochemistry and in situ hybridization for detection of p53 could be useful in the clinical evaluation of patients with thyroid carcinoma. And suggested that p53 mutations are involved in thyroid carcinogenesis and may play an important role in the malignant transformation of thyroid cancer.
Formulation of Lahuna Leave (Eupatorium odoratum) and Sirih Leave Extract (Piper betle L.) as Antiseptic Liquid Soap
Authors: Jumrah Elfira , Abubakar Andi Nur Fitriani , Agustina Ayu Safitri , Karneng Syahdam , Gusti Herdie Idriawien
Published: April 2023

Infectious diseases caused by microorganisms are the main cause of high morbidity and mortality in the world. One of the plants that have the potential as an antiseptic is a lahuna leaf. Lahuna leaves contain active antibacterial compounds and the addition of betel leaf to the liquid soap formulations can strengthen the activity of the antiseptic produced. The purpose of this research is to test the effectiveness of liquid soap formulations of lahuna leaves and betel leaves as an antiseptic. The methods used include phytochemical screening, physical observation of liquid soap formulations, and antibacterial activity tests using agar diffusion methods. The results of the phytochemical analysis showed that lahuna leaves contain flavonoids, tannins, terpenoids, and alkaloids, while betel leaves contain flavonoids, saponins, tannins, terpenoids, and alkaloids. The liquid soap formulation of lahuna leaves and betel leaves has a clear yellow color, distinctive aroma, liquid form, rough taste, and lots of foam and has very strong inhibition against Staphylococcus aureus which is characterized by clear zones formed for each formulation I (22.4 mm), formulation II (21.8 mm) and formulation III (20.1 mm). These results indicate the potential of liquid soap formulations of lahuna leaves and betel leaves as antiseptic soap.
Molecular Networking to Screen Macroalgal Secondary Metabolites: Case for West Timor Macroalgae
Authors: Turupadang Welem , Johanis Marskel
Published: April 2023

The research describes how molecular networking was used as a screening tool to prioritize the isolation workflow of 40 macroalgae sampled from West Timor waters, Indonesia, in addition to a Nuclear Magnetic Resonance-based (NMR) spectroscopy strategy. A mass spectrometry (MS) was employed to generate spectra that later be used as data to produce the molecular network with the Global Natural Product Social Molecular Networking (GNPS) website. The screening process used the molecular network, which assisted in the selection of six samples of macroalgae out of the 40 samples for further examination. Lastly, an NMR-based protocol was employed to choose the samples of interest to be investigated further. Six samples were shortlisted from the GNPS molecular network based on specimens, which were then validated with 1H NMR spectroscopy to finally prioritized three samples.
Pembinaan Peserta Didik di Madrasah Aliyah Swasta Pondok Pesantren Irsyadul ‘Ibad Batang Hari
Authors: Fadlilah  , Bawaihi  , Nuning Setia Ningsih
Published: April 2023

This study aims to describe the activities of coaching students at MA Pondok Pesantren Irsyadul 'Ibad Batang Hari. This research uses a qualitative approach. The informant selection technique uses snowball sampling. Data collection is carried out through observation, interviews, and documentation. Data analysis using interactive model analysis techniques by Miles and Huberman. The results showed that student development is based on the potential and interests of students which are contained in the form of student targets (achievement plans). There are two main components that are prepared in the development of students, namely accompanying teachers who meet the requirements as teachers in madrasahs and supporting facilities provided by involving the entire madrasah environment. In providing various learning services, MA Pondok Pesantren Irsyadul 'Ibad Batang Hari positions itself as an open system, so that madrasahs always make contact with the community and the surrounding environment to get support both pre, during and after the implementation of educational programs. Coaching intracurricular activities emphasizes more on character building and instilling a maturing culture which is reflected in the lack of regulations for students.
Optimalisasi Manajemen Sarana Prasarana di PAUD Nurul Ihsan Tanjung Jabung Timur
Authors: MY Mahmud , Riftiyanti Safitri  , Dwika Ristanti
Published: April 2023

This study aims to describe the process of infrastructure management at PAUD Nurul Ihsan Tanjung Jabung Timur which includes the procurement, distribution, maintenance and inventory of infrastructure. One of the efforts in improving the quality of PAUD is to meet adequate, quality infrastructure, in accordance with early childhood development, and ready-to-use infrastructure. Therefore, to improve the quality of PAUD, a good management of infrastructure is needed. This research uses a qualitative approach. Data collection is carried out through observation, interviews, and documentation. The results showed that the procurement of infrastructure was carried out from the disbursement of BOP (Educational Operational Assistance) funds, community contributions and parents of students. Maintenance is carried out by educators and education personnel. Inventory is carried out recording goods for each receipt of infrastructure.
Manajemen Hubungan Masyarakat di SMP Negeri 7 Muaro Jambi
Authors: Armida  , Savitri Riftiyanti , Erda
Published: April 2023

This study aims to determine the management of public relations at SMPN 7 Muaro Jambi which focuses on planning, implementing and public relations obstacles at SMPN 7 Muaro Jambi. This research uses descriptive qualitative research methods. Data collection using interview, observation and documentation methods. The results of this study show that the planning carried out by SMPN 7 Muaro Jambi compiles a public relations program that will be implemented by involving all school parties. The implementation of public relations is carried out in accordance with the public relations program plan that has been prepared. The hindrance factor for the public relations of SMPN 7 Muaro Jambi is that there is no special field of public relations so that the duties and responsibilities are still managed by the principal and school administration.
Manajemen Program Ujian Tahfidz dan Tahsin Al-Quran Juz 30 di Ma’had Al-Jami’ah sebagai Persyaratan Munaqosyah Mahasiswa UIN STS Jambi
Authors: Gumelar Agung
Published: April 2023

This study aims to determine the management of the tahfidz and tahsin Quran juz 30 exams at Ma'had Al-Jami'ah UIN STS Jambi. This research uses descriptive qualitative research methods. Data collection uses interview, observation, and documentation methods. The results of this study show that the management process of the tahfidz and tahsin Quran exams at Ma'had Al-Jami'ah UIN STS Jambi has carried out management functions, namely planning, organizing, implementing and evaluating. The planning of the tahfidz and tahsin Quran programs is carried out through the determination of targets, goal setting, method determination, method determination, and strategy determination. The implementation of the tahfidz and tahsin Quran programs has proceeded in accordance with the activity plans that are prepared in a structured and systematic manner. The control of the tahfidz and tahsin Quran programs has been carried out through activities to build cooperative relationships between supervisors and tutors, mentors in motivating tutors, mentors in fostering and directing tutors, and mentors in establishing communication with tutors.
Manajemen Pengolahan Koleksi Buku di Dinas Kearsipan dan Perpustakaan Kota Jambi
Authors: Jamaluddin Jamaluddin , Sumirah Sumirah , Hariyati
Published: April 2023

This study aims to determine the management of book collections, as well as the challenges and efforts made by the Jambi City Library and Archives Office. This research uses qualitative techniques and descriptive research design. Interviews, observations, and documents are used as data collection strategies. Data reduction, visualization, and verification techniques are used in data analysis (conclusions). Based on the results of field research, the management of book collections at the Jambi City Archives and Library Office includes the procurement of books, data verification, intervention, book stamps, classification, cataloguing, making cards and book bags, as well as providing barcodes before being placed on the bookshelf. In accordance with applicable norms and regulations, the number of books in the Jambi City Archives and Library Office is sufficient. Evaluate human resources by offering advice and training, and presenting them to librarian managers.
Manajemen Kepala Tata Usaha di MAN 2 Kota Jambi
Authors: Bawaihi  , Armida  , Leni Ardianti
Published: April 2023

This study discusses the Management of the Head of Administration of Madrasah Aliyah Negeri 2 Jambi City. The research approach that the authors use is descriptive qualitative, while data collection is carried out by Observation, Interview, Documentation. The purpose of this study is to find out how the Head of Administration in (Planning, Organizing, Implementing, Supervising) can help the Administration in improving its performance. The subjects in this study were the Head of Administration and Administrative Staff of Madrasah Aliyah Negeri 2 Jambi City. The object of this study is the Management of the Head of Administration of Madrasah Aliyah Negeri 2 Jambi City on the performance of the Madrasah Aliyah Negeri 2 Jambi City Administration. The results of this study found that the role of the head of administration has a significant impact on achieving the implementation of education in a school / madrasah. Because the existence of the head of administration plays a very important role. Administrative services will not run effectively without the role of the head of administration as a leader. In the implementation of administrative services, the head of administration is assisted by educational personnel. The condition of the administration in Madrasah Aliyah Negeri 2 Jambi City has been well organized as evidenced by the existence of a structural administrative organizational chart and the distribution of tasks in accordance with the field of subtlety. Because the administrative services of Madrasah Aliyah Negeri 2 Jambi City have been well organized, the quality of education in the school has become better, it is proven that Madrasah Aliyah Negeri 2 Jambi City has received "A" accreditation.
Manajemen Sarana dan Prasarana Pendidikan di Pondok Pesantren Darul Aufa Kabupaten Batanghari
Authors: Khalik Khalik , Fadlilah  , Nur Ainun Siregar
Published: April 2023

This study aims to determine the planning, procurement, maintenance and utilization of existing facilities and infrastructure at the Darul Aufa Muara Bulian Islamic Boarding School.This research uses a descriptive qualitative approach, the source of data obtained is from the Leadership, Waka Sarpras, and Students. The results showed that 1) the planning carried out at the Darul Aufa Islamic Boarding School was carried out at the beginning of each year, 2) the procurement carried out, namely receiving grants, buying, and making their own. 3) maintenance carried out, namely maintaining together and the existence of a list of pickets to take care of every day 4) utilization at this Islamic Boarding School is used which one is there first, then that is what will be used.
Внутрирегиональная миграция в Республике Бурятия: объемы, направления, последствия
Authors: Бюраева Ю.Г.
Published: April 2023

Статья посвящена исследованию проблем внутренней миграции в Республике Бурятия в 1990–2021 гг. Миграция рассматривается как определяющая компонента убыли населения муниципальных районов, за исключением пристоличных. Автор акцентирует внимание на изменении её структуры и географии. Делается вывод о смене центра притяжения миграционных перемещений на пригородные зоны столицы республики. Последняя значительно уступает пригородам по интенсивности миграционного прироста. Показано, что принимающие территории испытывают сильные нагрузки с позиции недостатка инфраструктуры и рабочих мест, ухудшения экологической обстановки. Кроме того, у переселенцев обнаруживается тенденция к сохранению элементов сельской культуры и образа жизни в городской местности. Отток чреват обезлюдением обширной сельской территории, старением ее населения и провоцированием следующего витка миграции.
Проблемы и перспективы развития особо охраняемых территорий в Пермском крае
Authors: Зайцев А.А. , Третьякова Е.А. , Шилова Е.В.
Published: April 2023

В статье рассматриваются ключевые проблемы управления особо охраняемыми территориями в Пермском крае и основные направления и инструменты их решения. Перечислены главные элементы и ключевые характеристики сети особо охраняемых зон, распределенной по шести природным районам, выделяемым в крае, подробно описана система управления ими, проанализированы возможные пути решения имеющихся проблем. Регрессионный анализ, проведенный на основе панельных данных по восьми федеральным округам за 2014–2020 гг. позволил выявить степень влияния особо охраняемых природных территорий на экономику региона.
Оценка сбалансированности развития регионов на основе Целей устойчивого развития
Authors: Алферова Т. В.
Published: April 2023

Исследование посвящено апробации методики оценки сбалансированности развития регионов на основе Целей устойчивого развития. Полученные для регионов Уральского и Приволжского федеральных округов индексы ЦУР показали практически повсеместно низкий уровень достижения целевых значений. Кроме того, обнаружено преобладание развития экономической сферы над социальной и экологической. Это говорит о том, что в данных регионах наибольшее внимание уделяется экономическому росту, что не соответствует принципам биосфероцентрической парадигмы. Низкое значение индекса по ЦУР 17 свидетельствует о недостаточном внимании к институтам управления, что и приводит к сложившейся ситуации.
FRACASSO ESCOLAR NO ENSINO SUPERIOR: O COTIDIANO DE UMA JOVEM COM VIVÊNCIAS DE DIFICULDADES ACADÊMICAS
Authors: Trindade Camila , Turati Pessoa Camila , Sanches Tessaro Leonardo Nilza
Published: April 2023

A partir da reorganização e ampliação do Ensino Superior brasileiro, sobretudo nas últimas décadas, as discussões acerca do denominado fracasso escolar têm sido ampliadas também para este nível de ensino. Objetivamos, a partir da Psicologia Histórico-cultural e das contribuições de Agnes Heller, analisar as relações entre o cotidiano universitário e a constituição das dificuldades acadêmicas a partir das vivências de uma estudante do Ensino Superior. Após os trâmites éticos, realizamos três diferentes momentos de diálogos, baseados em um roteiro de entrevista semiestruturada, que foram transcritas e analisadas. Observamos que a cotidianidade não é limitada aos aspectos acadêmicos, apesar dos diferentes processos desta articularem-se com tal formação. Depreendemos que é também a partir do cotidiano alienado, e com restritas possibilidades de sua superação, que são pavimentadas as condições para a formação das dificuldades acadêmicas vivenciadas pela estudante.
PAPEL DA ARTE NO ENSINO: UMA PERSPECTIVA DA PEDAGOGIA WALDORF
Authors: De Oliveira Martins Maíra
Published: April 2023

Neste trabalho pretendemos elaborar reflexões acerca do papel da Arte no ensino. Atualmente, podemos até interrogar o que é Arte, na medida em que nos tornamos cada vez mais distanciados dela na vida contemporânea. Desse modo, apresentamos uma perspectiva a partir dos pensamentos de Rudolf Steiner sobre o que é e qual a função da Arte para o ser humano. A partir da pesquisa bibliográfica, apresentamos algumas reflexões da importância do desenvolvimento do sentido artístico para a Pedagogia Waldorf, bem como algumas possibilidades de atuação artística, argumentando suas forças no desenvolvimento infantil. Chegamos ao pensamento de que é necessário ao ser humano atual recorrer à Arte como forma de desenvolver-se enquanto individualidade, na medida em que torna-se cada vez mais evidente a necessidade da consciência humana se unir à matéria, ou seja, uma integração entre ser humano e o mundo.
Historical foundations of the educational activities of the National Library of Russia
Authors:   federal state budget institution «National Library of Russia», Mikheeva Galina Vasil’evna
Published: April 2023

The state policy in the field of culture, as a fundamental element in ensuring the cultural sovereignty of Russia, provides for an increase in the role of education and enlightenment. The educational function immanently inherent in libraries, characteristic of all types of their activities, is characterized. The transformation of educational activities over the course of more than two hundred years of the historical path of the Imperial Public - Russian National Library is analyzed. The fundamental difference in the tasks of educational activities in the main library of the Russian Empire and in the period of the Сultural revolution and socialist construction of the 1920s–1930s was determined. The features of the educational activities of the National Library of Russia during the Great Patriotic War are characterized. The forms and methods of its implementation in the national library of the Russian Federation are revealed, their special role in changing historical conditions is shown.
«Границы музея» как предмет профессиональной рефлексии
Authors:   federal state budget educational institution of higher education «Saint Petersburg State University of Culture», Balash Aleksandra Nikolaevna
Published: April 2023

The review offers analysis of the scientific discussion, which was held by participants of All-Russian scientific and practical seminar, organized by the Chair of Museology and Cultural Heritage of SPb State University of Culture in February 2023. The main subject in discussion was a new definition of the notion “Museum” as adopted by 26th General Conference and incorporated in the Charter of ICOM. The said event was interpreted by the participants of the Seminar as a milestone in determination of the social and cultural mission of museum in modern society. It is also important for the development of museology, which is involved in the formation of modern cultural medium due to its scientific and educational importance. The Seminar was dedicated to 90th anniversary of the professor of culturology, Dr. V. P. Gritzkevitch. The review of the positions of the speakers was compiled based on the materials of the video recording of the seminar in order not only to record and summarize the results of its work, but also to give impetus to the professional reflection of the museum community.