bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS ENVIRONMENTAL AWARENESS VALUE DAN GREEN PRACTICES TERHADAP KEPUTUSAN PEMBELIAN KONSUMEN
Authors: Juliana Juliana , Pramezwary Amelda , Djakasaputra Arifin , Novia Widjaja Jessica , Virgiana Wijaya Jessica
Published: October 2021

Food and Beverage products or food and beverages are growing and growing rapidly. However, plastic becomes the raw material of F&B packaging until now is still a pro cons due to the health influence of the chemicals contained in it and not environmentally friendly. The environmental damage is now getting worse and has raised concerns. As knowledge increases, consumers increasingly know how to spend their money. Environmental Awareness value and Green Practices are considered by consumers to make a purchasing decision  on a  product. The purpose of this study was to analyze the influence of Environmental Awareness value and Green Practices on Consumer Purchasing Decisions on F&B Products.  

Research was conducted online by distributing questionnaires through google forms to 96 respondents using descriptive quantitative analysis methods and data analysis  using multiple linear regression tests, determination coefficient tests and F tests and t tests, which were processed with the SPSS program. The results showed that Environmental awareness value and green practices showed a positive and significant influence on consumer purchasing decisions on F&B Products.

Key Words: Environmental Awareness value , Green Practices, Purchase Decision
PENGGUNAAN PANGGUNG BONEKA INTERAKTIF UNTUK MENINGKATKAN KEMAMPUAN INTERAKSI SOSIAL ANAK USIA DINI
Authors: Alvan Hazhari  , Uum Sumiyati
Published: October 2021

Pentingnya pendidikan anak usia dini saat ini telah menjadi perhatian internasional. Dalam pertemuan Forum pendidikan dunia tahun 2000 di Dakkar, Senegal, telah menghasilkan enam kesepakatan sebagai kerangka aksi pendidikan untuk semua (The Dakkar Frame Work for Action Education for All) yang salah satu butirnya menyatakan: “Memperluas dan memperbaiki keseluruhan perawatan dan Pendidikan Anak Usia Dini (PAUD), terutama bagi anak-anak yang sangat rawan dan kurang beruntung”. Tujuan penelitian ini adalah untuk   mengetahui   peningkatan kemampuan interaksi sosial anak usia dini. Peneltian ini adalah penelitian kepustakaan (Library Research ), Pengumpulan data peneliti menggunakan Primer : reduksi data, display data, kesimpulan, Sekunder : buku, artikel, skripsi,  dan  jurnal. Hasil penelitian yang telah dilakukan memperoleh hasil persentase yang menunjukan adanya peningkatan interaksi sosial, terlihat dalam kode kode data A1 65,6% meningkat menjadi 88,1%  sehingga peningkatan yang diperoleh  dari A1 sebanyak 16 %. Data A2 dari 56,63% menjadi 93,83% sehingga peningkatan yang diperoleh  dari A2 sebanyak 37, 20 %. Data A3 dari 54 % menjadi 70% sehingga peningkatan yang diperoleh  dari A2 sebanyak 16 %. Sehingga persentasi nilai rata-rata untuk meningkatkan motorik halus pada anak usia dini dengan media panggung boneka interaktif meningkat signifikan yaitu dari 58,74% sebelum menggunakan media tersebut menjadi 83,97% sesudah menggunakan media panggung boneka dan peningkatannya sebesar 23,06 %. Maka hal ini dapat disimpulkan bahwa model Penggunaan media panggung boneka interaktif dapat meningkatkan interaksi sosial pada anak usia dini.
THE EFFECT OF FINANCIAL KNOWLEDGE AND PERSONAL NET INCOME ON THE FINANCIAL BEHAVIOR OF MALIKUSSALEH UNIVERSITY EMPLOYEES WITH LOCUS OF CONTROL AS MODERATING VARIABLES
Authors: Khaddafi Muammar , Aryani Risa Aryani , Heikal Moh.
Published: October 2021

The Influence of Financial Knowledge and Personal Net Income on Financial Bihaviour of Universitas Malikussaleh Employees with Locus Of Control as Moderation Variable. The purpose of this study was to determine how the model of financial behaviour of civil servants and lecturers in the Malikussaleh University environment and what factors are the most powerful in influencing the financial behaviour of employees in the Malikussaleh University campus environment. The research sample taken from the population in this study were 261 Civil Servants Group II to Group IV in Universitas Malikussaleh. The method used to support this research is quantitative method and in this study using multiple linear regression models. The processing and interpretation of research data using statistical software SmartPLS. The results of data analysis in this study indicate that financial knowledge has a positive and insignificant effect on the financial behaviour of Universitas Malikussaleh employees. Personal net income has a positive and significant effect on the financial behaviour of Universitas Malikussaleh employees. Locus of control does not moderate the effect of financial knowledge on financial behaviour of Universitas Malikussaleh employees. Locus of control does not moderate the effect of personal net income on the financial behaviour of Universitas Malikussaleh employees.
Ten Years of Clinical Evaluation of the Woven EndoBridge: A Safe and Effective Treatment for Wide-Neck Bifurcation Aneurysms
Authors: Pierot Laurent
Published: October 2021

Intrasaccular flow disruption is an innovative approach for the endovascular treatment of intracranial aneurysms. As of now, only one device is currently available worldwide: the Woven EndoBridge (WEB) device (MicroVention, Aliso Viejo, CA, USA). After 10 years of clinical use and careful clinical evaluation of the WEB device by multiple prospective, multicenter studies, this article is summarizing the current knowledge regarding this endovascular technique; indications, modalities, safety and efficacy of the WEB procedure are described.
The palmaris longus muscle: A surface study of the population of North Cyprus
Authors: ALIYU Maryam N , TIRYAKIOGLU Mehtap
Published: October 2021

Objective: The aim of this research is to determine the frequency of surface anatomical variations of palmaris longus (PL) muscle inthe population of North Cyprus and their association with gender, body side, and hand dominance.Materials and Methods: The presence of PL was determined in 1280 subjects (660 females and 620 males) using four testing methods;Schaeffer’s test, the Thompson’s test, Pushpakumar’s test and the Bhattacharya’s test. Where the presence of the PL could not bedetermined by any of these tests, palpation was performed as the final confirmatory test.Results: The overall frequency of absence was 17.4%. Female subjects showed a higher frequency of absence of 10.6% compared tomales (6.8%). The absence was more likely to occur in the non-dominant hand. In those that had the PL, there were 28 (2.6%) casesof a split tendon and 3 cases (0.2%) of a laterally displaced tendon of the PL.Conclusion: The overall frequency of absence of PL in North Cyprus was 17.4% and absence is more likely to occur in females, on theleft side and in the non-dominant hand. Other variations recorded are the split tendons and laterally displaced tendons.
Problems of water separation from diesel fuel
Authors: Górska-Włodarczyk Wioletta
Published: October 2021

This study presents the effect of water on the quality of diesel fuel, including the chemical
effects of its presence in the fuel. The issues of purifying diesel fuel from water (i.e. its separation from
fuels) with the currently used filtering materials were analysed. The possibilities of improving the
efficiency of the water pollution removal process through the use of filters made of graphene materials
were presented, based on tests performed for other types of fuels. Additionally, the bactericidal
properties of graphene compounds were indicated, which show the ability to eliminate a microbial
contamination of fuels occurring in the presence of water.
Keywords: diesel fuel, water separation, graphene filters, fuel filtration
Mobile engine test station for preparation and operation of miniature turbine jet engines for flying aerial targets
Authors: Chachurski Ryszard , Omen Łukasz , Panas Andrzej J. , Zalewski Piotr
Published: October 2021

The work presents description and operation of the mobile engine test station, designed for
the miniature turbine jet engines with a maximum trust below 200 N. The engine test bed allows us to
monitor the condition of the engine used to drive remotely controlled flying aerial targets or military
unmanned aircraft. According to military (Department of Defence) requirements, the designed engine
test station is mobile, it can be used in military battlefield conditions and it meets safety precautions
and military transport requirements. The reason of the engine investigations was the shortage and lack
of information on the engine capability and suitability to work in the field conditions, and first of all
on its limitations. The designed engine test station successfully completed tests in laboratory as well
as in military field conditions and nowadays it is an integrated part of the Aerial Flying Target System
called the ZOCP-JE2 that is designated for the engine’s monitoring and checking before the flight.
Keywords: life cycle monitoring, miniature turbine jet engines, diagnostic procedures
On the possibility of surface transversal wave guidance in an elastic subsurface layer of cubic crystal systems with periodic material inhomogeneities
Authors: Kapelewski † Jerzy , Pasternak Mateusz
Published: October 2021

In the paper, the possibility of surface transversal waves existence on an elastic surface layer with artificially induced periodic inhomogeneities has been described. Such kind of waves, unlike well-known surface modes sustained close to the surface boundary by an elastic layer as well
as constant or periodic electrical short, have potential to transfer higher energy with higher velocity. Such parameters are very important for applications of sensors. In the work, some outline of the theory, chosen qualitative aspects of such wave propagation on regular crystal surfaces as well as the results
of preliminary experimental tests were presented.
The Problem of the Colorectal Anastomosis
Authors: Ionescu Sinziana
Published: October 2021

Colorectal anastomosis is defined as a surgical procedure in which the colon is attached to the remainder of the rectum after most or some part of it was removed during an intervention. A straight colorectal anastomosis implies a direct attachment, while a J-pouch colorectal anastomosis implies a previous creation of a reservoir, or “pouch” out of bowel material. The problem of colorectal anastomosis safety and outcome is among the most important and persistent issues in colorectal surgery, mainly due to the anastomotic leakage, a threatening and dangerous complication, with an incidence of up to 20% or even more in case of surgical oncology. Various prediction models and anastomosis testing techniques have been described in order to prevent or identify early any possible imperfection of the anastomosis, each with pros and cons. The measures generally used to increase the safety and reliability of the colorectal anastomosis are to evaluate the blood supply of the tissues anastomosed with indocyanine green, or to test the mechanical integrity of the anastomosis for leakage by employing air, methylene blue, or tension.
Überlegungen zur hermeneutischen Terminologie und zur Aufgabe des Übersetzers vor dem Hintergrund der Performanz
Authors: Stefanink Bernd
Published: October 2021

Many representatives of the hermeneutical approach in Translation Studies complain about the lack of consideration for their undertaking. One of the reasons seems to be the lack of coherence and clarity in their terminology. Another reason might be the lack of group cohesion. Based on my long-lasting correspondence with the main representative of translational hermeneutics, Radegundis Stolze, as well as on my review of her books, the following paper examines both the revelatory and heuristic role played by terminology, which we think to be of major importance in the framing of a theory in human sciences. The importance of that role informs my own account of the introduction of a new term and the role it is also meant to play. Specifically, what is at issue is the term „performance” and what it suggests as to this role in pragmatic texts. With regard to group cohesion, it invites us to have a better, group-based, internal communication (as is exemplified in my intensive mail exchange with Stolze and in my book reviews), in order to close ranks and speak with a more coherent hermeneutical voice. This implies, for instance, a wider use of cross-references which should not be limited to texts in English or German. It also implies a recognition of the scientific status of book reviews, which should be considered as the author’s partnerin an epistemological (erkenntnisfördernd) dialogue, similar to the conversation envisaged by Gadamer, the aim of which would be to promote and deepen mutual comprehension.
Molecular phylogeny reveals a new genus of freshwater mussels from the Mekong River Basin (Bivalvia: Unionidae)
Authors: Jeratthitikul Ekgachai , Sutcharit Chirasak , Ngor Peng Bun , Prasankok Pongpun
Published: October 2021

A new genus of freshwater mussels (Bivalvia: Unionidae) is described from the Mekong River Basin as Namkongnaia gen. nov. The validity of the new genus is supported by its unique conchological characteristics, namely the lack of hinge dentition and elongated shells, together with its evolutionary distinctiveness as estimated by multi-locus phylogenetic analyses (mitochondrial COI and 16S, and nuclear 28S genes). The new genus includes two lineages with deep divergence, shown by 5.10% uncorrected COI p-distance. One lineage is a type species described herein as Namkongnaia inkhavilayi gen. et sp. nov. The other is a recognized species under the name ‘Pilsbryoconcha lemeslei (Morelet, 1875)’. Molecular phylogenetic analysis further shows that the new genus belongs to the tribe Pseudodontini, and evolutionarily is closely related to the genus Monodontina Conrad, 1853. However, its conchology is similar to the genus Pilsbryoconcha Simpson, 1900. Time-calibrated phylogeny suggests that the main radiation events of the tribe Pseudodontini occurred during the Late Cretaceous to the Eocene, with the divergence between the new genus and Monodontina placed in the Miocene. The discovery of new freshwater mussel taxa in this study highlights the importance of the Mekong River Basin as one of the world’s biodiversity hotspots for freshwater fauna.
Cross-border Succession issues and the attempts of Serbian legislation to be harmonized with the European legislation on succession matters
Authors: de Negri
Published: October 2021

The study deals with the importance of harmonization processes related to the succession rules in the European Union. During the examination of the harmonization processes, a particular attention has been paid to migration, which nowadays has a deep impact on inheritance cases. In this regard the study demonstrates how the judicial cooperation is being realized in the European Union when it comes to succession-related issues. Among these, the study examines the current norms of the Serbian Act on private international law, which, from some aspects, has an obsolete system considering the conflict of laws rules in matters of succession with an international element. Namely, these rules are not harmonized with those of the European Succession Regulation, which means that the Serbian IPL system does not currently follow the European trends in legislation. Furthermore, it does not take into consideration certain current phenomena, especially the international migration and globalization. At the same time, Serbia is working hard to achieve a certain level of legal harmonization with the EU legislation. One proof of the harmonization attempts is the draft of the new PIL act of Serbia. The new concept of the conflict of laws rules and the new systemic approach of connecting factors is nearly completely identical with that of European legislative trends, especially regarding the scope of succession. If the draft act comes into force, it will mean, beyond any doubt, a giant leap for the country towards the European Union.
Regulation of restrictive agreements in Republic of Serbia with a reference to the European Union law
Authors: Blagojević Bojan
Published: October 2021

This paper explores the questions regarding regulations of restrictive agreements in Republic of Serbia as well as in the European Union. Moreover, it has a concept of a competition explained in order to make the importance of the exemption of agreements with the competition infringement noticed. The measures and requirements for protection of competition are presented as well. The aim of the paper is to present the importance of restrictive agreements, and to explain if the market should be protected only from an individual agreement or from all restrictive agreements. Moreover, the point whether the competition is protected from all infringements or just from some of them is explored. From all this stated, it can be concluded that there are big discrepancies in regulations against competition infringement in legal regulations of Republic of Serbia in comparison with regulations of the European Union.
Criminal offenses against property seen from an angle of basic institutes of law: Things and real rights
Authors: Lazić Dragana , Stanković Sanja , Danilović Aleksandra
Published: October 2021

Based on the data from official documents of the Republic Statistical Office and judicial institutions of the Republic of Serbia, the paper analyzes and presents the results of research related to the threat to property and real rights in the Republic of Serbia in the period from 2009 to 2019. We performed the analysis of available data in order to detect the "loss of crime" in a group of crimes aimed at protecting property. The purpose of this paper is a causal analysis of crimes against property in the entire territory of the Republic of Serbia with the aim of revealing causal relations and links between the number of reported, accused and convicted persons for these crimes, to determine the degree of loss of crime and take systemic measures to reduce that loss measure, in accordance with the standards of developed countries.
Polycyclic aromatic hydrocarbons, their urinary metabolites and health
Authors: Radosavljević Vladan
Published: October 2021

The World Health Organization (WHO) stated as one of its conclusions that air pollution is a leading environmental health risk. Polycyclic aromatic hydrocarbons (PAHs) are well-known carcinogens (above five hundred compounds) that cause lung and skin cancer, especially in occupationally exposed workers. By significantly reducing emissions from modern combustion plants, traffic control, and strict smoking bans in public places, PAHs exposure can be reduced. PAH exposure ought to be better investigated, especially in the field of mass biomonitoring of the urinary concentrations of their major metabolites. Such biomonitoring ought to integrate exposures to chemical carcinogens from different sources (air, water, food, consumer products, professional procedures, etc.), as well as exposure to chemical noxae through the respiratory tract by (inhalation), digestive tract (ingestion), or through the skin. Analysis of the concentration of main PAHs metabolites in urine must be done with highly sophisticated equipment for a valid database to be obtained. The data thus obtained are necessary for risk assessment and health policymaking in order to reduce exposure to chemical carcinogens.
The assessment of the influence of women's attitudes about screening benefits and motivational factors on their participation in the Papanicolau screening test
Authors: Jovanović Vesna , Pažun Vanja , Maksimović Vesna , Vuković Vesna
Published: October 2021

Introduction: In Serbia, cervical cancer (CC) is the second most common cancer, after breast cancer, The Papanicolaou test is used for the early detection of cervical cancer. Motivational factors and attitudes of women about the benefits of the Papanicolaou screening test can affect the rate of participation in it. The aim of the research was to examine whether there is a connection between women's attitudes about the benefits of screening and motivational factors and their participation in the Papanicolaou screening test of CC. Methods: This cross-sectional study included 300 women aged 25 to 64, who came for a gynecological examination to the Gynecology and Obstetrics Clinic "Narodni Front" in Belgrade, in the period from June to December 2015. Data were collected from all respondents on their demographic characteristics, reason for coming to the clinic, how often they underwent screening (Papanicolaou test), as well as data on their attitudes about the benefits of screening and motivation for undergoing the Papanicolaou screening test using a part of the questionnaire called CPC -28 questionnaire (in Spanish Creencias, Papanicolaou, Cancer - 28). Results: Of the 300 women who participated in the study, 37.3% of women regularly participated in the Papanicolaou test, 43.7% irregularly, and 19.0% never. Women who participated regularly in screening were significantly more likely to believe that it was important to have a regular Pap test to know they were healthy (F = 13.59; p ˂ 0.001) and that the Pap test was the best way to determine early-stage CC (F = 12.29; p ˂ 0.001) compared to women who were irregular and who had never participated in screening. Women who participated irregularly or who had never participated in the screening program would be motivated to participate in it significantly more often if someone developed CC in their family or environment (F = 5.11; p = 0.007), while women who regularly participated would be motivated significantly more often by gynecologist's recommendations (F = 5.58; p = 0.004) and care for their own health (F = 6.93; p = 0.001). The high level of motivation was significantly related to the decision of women to regularly participate in screening (ch² = 13.05; p = 0.001) in relation to women who were irregular or who had never participated in screening. Conclusion: Within this research, it was noticed that only every third respondent regularly underwent the Papanicolaou screening test, which is far lower than the set national goals that at least 75% of the target population of women aged 21 to 69 should be covered by organized screening. It is necessary to raise women's awareness about the importance of Papanicolaou screening for early detection of CC, as well as about all other preventive measures, and especially about the importance of the HPV vaccine.
Music for All: accesibilidad e inclusión en los festivales de música
Authors: Costa Gálvez Lola
Published: October 2021

Mucho se ha hablado de las restricciones a los eventos en directo a causa de la pandemia. Sin embargo, para muchas personas acceder a los espectáculos en directo siempre ha sido un reto. Según la OMS, alrededor del 15% de la población mundial son personas con discapacidad, lo que en el caso de España son más de tres millones de personas. Para estas personas no siempre es posible acceder a la oferta de ocio existente.
ДРУШТВЕНЕ МРЕЖЕ ТОКОМ ПАНДЕМИЈЕ- ИНФОРМАЦИЈА ИЛИ ДЕЗИНФОРМАЦИЈА
Authors: Бериша Хатиџа , Митић Јелена
Published: October 2021

Током присутне пандемије ковида вируса, видно је забележено велико интересовањезапраћења медија. Посебно пандемија на глобалном нивоу променила је начин на које се одређене категорије људи тежиле ка вестима и другим садржајима информисања. Појава корона вируса изазвала је велики пораст информисања у форми вести, али такође, важно је указати да су вести односно информације добиле другу форму и све више пренос се врши у оналај форматима. Свет који је захваћен паником, пуно непознаница о новој појави вируса, шире се дезинформације које постају део свакодневнице, губи се осећај између праве и стварне информације, па често долази у оптицај и нови називи као што је инфодемија (ширење лажних вести). У раду се анализира долазак револуционарне технологије кроз деловање друштвених мрежа, које у зависности од развоја и степена ширења ковид вируса добија различите улоге, у једном тренутку делују позитивно пружајући значајне информације, док у другом негативном тренду кроз ширење разних дезинформација шири панику и страх код људи и јавности.
UTICAJI LJUDSKIH RESURSAI I ITTEHNOLOGIJA NA HOTELIJERSTVO U 21.VEKU
Authors: Stojkanović Denis , Petković Zdravka
Published: October 2021

Da bi kompanija mogla da se takmiči, mora imati bar jednu konkurentsku prednost više od ostalih kompanija. Danas većina kompanija ima pristup svim istim tehnologijama, tako da tehnologija sama po sebi nije dovoljna da izdvoji jednu kompaniju od ostalih. Savremeni menadžment u prvi plan stavlja ulogu i značaj zaposlenih i važnost psiholoških faktora kao što su (sposobnosti, ciljevi, motivi, očekivanja za uspešno poslovanje preduzeća). Upravljanje ljudskim potencijalima nerazdvojno ujedinjuje odluke koje imaju presudne i dugoročne efekte za poslovno ponašanje i uspešnost hotelskog preduzeća. Budućnost hotelijerstva predviđena je na temelju brojnih projekcija koje uključuju ekološku održivost poslovanja te primenu savremene informacijske tehnologije.
GLOBALNI LANCI PROIZVODNJE I EKONOMSKE SLOBODE U ZEMLJAMA U RAZVOJU
Authors: Vidović Nikola
Published: October 2021

Fragmentacija lanaca proizvodnje i autsorsing su jedne od glavnih ekonomskih posljedica globalizacije i jedna od obilježja savremene svjetske industrije. U procesu fragmentacije, dijelovi lanaca proizvodnje se iz različitih razloga razmještaju u države širom svijeta, a najviše u zemlje u razvoju. Ovaj rad objašnjava mehanizme i razloge preseljenja dijelova proizvodnih procesa u zemlje u razvoju, te ulogu ekonomskih sloboda na integraciju ekonomija zemalja u razvoju u globalne lance proizvodnje. U radu je uz analizu dosadašnje literature koja se bavi ovom temom i pokriva uglavnom liberalizaciju trgovinskih i tokova kapitala, objašnjeno kako i ostali aspekti ekonomskih sloboda utiču na integraciju u globalne lance proizvodnje, te zašto je ona potrebna zemljama u razvoju.
ETIKA I GLOBALIZACIJA U BANKARSTVU
Authors: Poštin Jasmina , Ćilerdžić Vesna , Jagodić Rusić Aleksandra , Strahinja Stojković Hadži
Published: October 2021

Ova studija ispituje uticaj globalizacije na bankarski sektor i etičko upravljanje pred finansijskim zakonima kao ključ za efikasno upravljanje u neizvesnim vremenima. Globalna finansijska kriza je snažno pokazala kako su međunarodne banke uticale na šokove širom sveta. Globalizacija bankarske proizvodnje i internacionalizacija tržišta finansijskih usluga doveli su do toga da se bankarski menadžeri specijalizuju znanjima iz brojnih naučnih oblasti, između ostalog i poslovne etike i morala. Kako je sveprisutna dilema između ekonomije i etike, značaj etičkog stila upravljanja predstavlja izazov za organizaciono upravljanje i iniciranje kulturne promene vođene moralnim normama i primenom etičkih standarda.
OBRAZOVANJE ZA PODUZETNIŠTVO – POKRETAČ KONKURENTNOSTI U BOSNI I HERCEGOVINI
Authors: Piljić Jozo
Published: October 2021

Preduvjet za uspješan i kontinuiran rast i razvoj te konkurentnost nacionalne ekonomije je sustavno obrazovanje za poduzetništvo. Ono treba biti sadržano u obrazovnim programima na svim razinama formalnog, neformalnog i informalnog obrazovanja i osposobljavanja. Usvajanjem i podizanjem poduzetničkog obrazovanja povećava se i konkurentska sposobnost nacionalne ekonomije. Na taj se način osigurava pretpostavka za povećanje stupnja zapošljivosti stanovništva. Konkurentnost nacionalne ekonomije ogleda se i u sposobnosti stalnog dinamičkog prilagođavanja koje uvjetuju brze promjene u nauci i tehnologiji kao i proces globalizacije. Svaki pojedinac se susreće s izazovom stalne potrebe za učenjem i promjenama zaposlenja za koje su potrebna posebna znanja i vještine. U Europskoj uniji već odavno se vodi politika cjeloživotne karijerne orijentacije. U Bosni i Hercegovini karijerna orijentacija je tek u povoju. Ekonomija i tržište rada u Bosni i Hercegovini sve više su pod utjecajem jake konkurencije zbog čega je potrebno brzo prilagođavanje, kontinuiran razvoj i inovativnost domaćih poduzeća.
Regulation of signal transduction pathways in colorectal cancer: implications for therapeutic resistance
Authors: Yeoh Yeelon , Low Teck Yew , Abu Nadiah , Lee Pey Yee
Published: October 2021

Resistance to anti-cancer treatments is a critical and widespread health issue that has brought serious impacts on lives, the economy and public policies. Mounting research has suggested that a selected spectrum of patients with advanced colorectal cancer (CRC) tend to respond poorly to both chemotherapeutic and targeted therapeutic regimens. Drug resistance in tumours can occur in an intrinsic or acquired manner, rendering cancer cells insensitive to the treatment of anti-cancer therapies. Multiple factors have been associated with drug resistance. The most well-established factors are the emergence of cancer stem cell-like properties and overexpression of ABC transporters that mediate drug efflux. Besides, there is emerging evidence that signalling pathways that modulate cell survival and drug metabolism play major roles in the maintenance of multidrug resistance in CRC. This article reviews drug resistance in CRC as a result of alterations in the MAPK, PI3K/PKB, Wnt/β-catenin and Notch pathways.
Studies on Seed Dormancy Breaking in Cucumber (Cucumis sativus L.) Variety Poinsett
Authors: Nandhini Devi H. Usha , Renugadevi J. , Rajasree V. , Pugalendhi L.
Published: October 2021

Experiments were carried out to study the effect of chemicals in breaking the dormancy of cucumber. The study was conducted at the Department of Vegetable Science, Horticultural College and Research Institute, Coimbatore during 2017-2018. The seeds of cucumber variety Poinsett were treated with various chemicals immediately after harvest to standardize the best dormancy breaking treatment. The design of the experiment was Factorial Randomised Block Design with two replications. The seeds were treated with the chemicals for 12 hrs and 24 hours duration. The germination test was conducted. Observations on seed and seedling quality parameters viz., speed of germination, and germination percent, vigor index I and vigor index II were recorded. At 12 hours duration, the highest speed of germination (23.29) was recorded in T2 (GA3150 ppm) whereas the highest germination percentage (92) was recorded in T8 (Ethrel150 ppm). At 24 hours duration, the highest speed of germination (30.77) and the highest germination percentage (86) was observed in T12 (KNO3500 ppm). At 12 hours duration, the highest Vigor Index I (2800.16) was recorded in T9 (Ethrel 500 ppm) while the vigor Index II was the highest (12.19) in T8 (Ethrel150 ppm). At 24 hours duration, the highest Vigor Index I (2349.28) was observed in T10 (Ethrel 1000 ppm) while the vigor Index II was the highest (14.066) in T11 (KNO3150 ppm).
A Sodium–Antimony–Telluride Intermetallic Allows Sodium‐Metal Cycling at 100% Depth of Discharge and as an Anode‐Free Metal Battery
Authors: Wang Yixian , Dong Hui , Katyal Naman , Hao Hongchang , Liu Pengcheng , Celio Hugo , Henkelman Graeme , Watt John , Mitlin David
Published: October 2021

Repeated cold rolling and folding is employed to fabricate a metallurgical composite of sodium–antimony–telluride Na2(Sb2/6Te3/6Vac1/6) dispersed in electrochemically active sodium metal, termed “NST‐Na.” This new intermetallic has a vacancy‐rich thermodynamically stable face‐centered‐cubic structure and enables state‐of‐the‐art electrochemical performance in widely employed carbonate and ether electrolytes. NST‐Na achieves 100% depth‐of‐discharge (DOD) in 1 m NaPF6 in G2, with 15 mAh cm−2 at 1 mA cm−2 and Coulombic efficiency (CE) of 99.4%, for 1000 h of plating/stripping. Sodium‐metal batteries (SMBs) with NST‐Na and Na3V2(PO4)3 (NVP) or sulfur cathodes give significantly improved energy, cycling, and CE (>99%). An anode‐free battery with NST collector and NVP obtains 0.23% capacity decay per cycle. Imaging and tomography using conventional and cryogenic microscopy (Cryo‐EM) indicate that the sodium metal fills the open space inside the self‐supporting sodiophilic NST skeleton, resulting in dense (pore‐free and solid electrolyte interphase (SEI)‐free) metal deposits with flat surfaces. The baseline Na deposit consists of filament‐like dendrites and “dead metal”, intermixed with pores and SEI. Density functional theory calculations show that the uniqueness of NST lies in the thermodynamic stability of the Na atoms (rather than clusters) on its surface that leads to planar wetting, and in its own stability that prevents decomposition during cycling.
Extreme Environmental Thermal Shock Induced Dislocation‐Rich Pt Nanoparticles Boosting Hydrogen Evolution Reaction
Authors: Liu Siliang , Shen Yi , Zhang Yang , Cui Baihua , Xi Shibo , Zhang Jinfeng , Xu Lianyong , Zhu Shuze , Chen Yanan , Deng Yida , Hu Wenbin
Published: October 2021

Crystal structure engineering of nanomaterials is crucial for the design of electrocatalysts. Inducing dislocations is an efficient approach to generate strain effects in nanomaterials to optimize the crystal and electronic structures and improve the catalytic properties. However, it is almost impossible to produce and retain dislocations in commercial mainstream catalysts, such as single metal platinum (Pt) catalysts. In this work, a non‐equilibrium high‐temperature (>1400 K) thermal‐shock method is reported to induce rich dislocations in Pt nanocrystals (Dr‐Pt). The method is performed in an extreme environment (≈77 K) created by liquid nitrogen. The dislocations induced within milliseconds by thermal and structural stress during the crystallization process are kinetically frozen at an ultrafast cooling rate. The high‐energy surface structures with dislocation‐induced strain effects can prevent surface restructuring during catalysis. The findings indicate that a novel extreme environmental high‐temperature thermal‐shock method can successfully introduce rich dislocations in Pt nanoparticles and significantly boost its hydrogen evolution reaction performance.
A Lithium‐Silicon Microbattery with Anode and Housing Directly Made from Semiconductor Grade Monocrystalline Si
Authors: Sternad Michael , Hirtler Georg , Sorger Michael , Knez Daniel , Karlovsky Kamil , Forster Magdalena , Wilkening H. Martin R.
Published: October 2021

Miniaturized and rechargeable energy storage systems, which easily power smart and (in vivo) sensors or the wirelessly networked transmitting devices of the so‐called internet of things, are expected to open unprecedented ways for how information can be shared autonomously. On the macroscale, such battery‐powered devices have already revolutionized our daily life by the use of mobile phones and portable computers. The eagerly‐awaited advent of sufficiently powerful and long‐living microbatteries will definitely make our lives more comfortable, especially in sectors such as medicine, security, autonomous driving or artificial intelligence in conjunction with fields where information need to be quickly shared, also including pandemic‐like situations. Here, a fully matured lithium‐ion microbattery with millimeter‐sized dimensions that can be manufactured by mass production methods well‐established in semiconductor industry is presented. The battery can directly be machined from wafer‐grade monocrystalline silicon which acts as both the electrochemically active anodic part and, at the same time, as the electrically insulating housing material of the accumulator. The high current output power (200 mW cm−2; 30 mA peak current) and the solid charge‐discharge stability of at least 100 cycles (10 mAh cm−2), combined with a high Coulombic efficiency near 100%, make the device ideally suited to be implemented in a large range of intelligent, self‐powered electric devices.
Agricultural extension and advisory services strategies during COVID‐19 lockdown
Authors: Baffoe‐Bonnie Anthony , Martin David Tanner , Mrema Frank
Published: October 2021

The COVID‐19 lockdown policies that began in 2020 caused an unprecedented shock to developing countries’ agricultural activities, especially those in sub‐Saharan Africa and South Asia. To reduce some of the impacts of COVID‐19 events, agricultural extension and advisory personnel created an avenue to assist farmers in these developing countries. However, since COVID‐19 protocols restricted public gatherings and close contact activities, agricultural extension activities had to be performed using unconventional ways such as mobile phones, radio, and television. This paper highlights some of the challenges agricultural extension and advisory service personnel encountered using these unconventional means of communication for their activities. We also present some solutions to these challenges that can enable policymakers to enhance agricultural extension activities performed unconventionally.
Optoelectronic Functionality of BiFeO3–SrTiO3 Interface
Authors: Zhang Hang‐Bo , Alexe Marin
Published: October 2021

One effective way to extend the functional degree of freedom for semiconductors is to introduce structural defects (e.g., surface or interface) and chemical defects as they commonly exist and modify the properties of the entity. Here, the optoelectronic properties of bismuth ferrite thin films and their tuning by the interface between the film and the strontium titanate substrate are reported. The defects that have been demonstrated, especially oxygen vacancies, are of paramount importance in the photoelectric properties of a film‐substrate system. A detailed analysis of the oxygen vacancy levels supports the role of the interface in carrier transport. These results provide a new strategy to design the optoelectronic device via usual defect doping and interface coupling.
Mechanistic insights into the oxidation of catalytically relevant AgCu near‐surface alloy interfaces
Authors: Cramer Laura A. , Deshlahra Prashant , Sykes E. Charles H.
Published: October 2021

Recent heterogeneous catalysis studies have demonstrated that synergy between Ag and Cu can lead to more selective partial oxidation chemistries. We performed a series of scanning tunneling microscope experiments to gain a better understanding of the AgCu system under oxidative conditions. These experiments were carried out by exposing sub‐monolayer coverages of Ag on Cu(111), in the form of a near‐surface alloy (NSA), to range of oxygen exposures and temperatures. This enabled us to study the initial stages of oxidation of well‐defined Ag/Cu interfaces with atomic resolution and thereby understand the dynamic response of the AgCu NSA to oxygen environments. At low oxygen exposures, oxidation was observed on exposed Cu terraces and at the interface between the AgCu NSA and Cu(111). Higher oxygen exposure led to the segregation of Cu atoms up through the Ag layer and the appearance of surface adsorbed oxygen. Significant phase segregation of Cu was then observed at higher oxygen exposures at elevated temperatures, evidenced by the formation of Cu oxide patches within and on the top of the Ag layer. These results provide a more detailed picture of how AgCu NSAs interact with, and restructure in response to, oxygen.
Congenital X‐linked neutropenia with myelodysplasia and somatic tetraploidy due to a germline mutation in SEPT6
Authors: Renella Raffaele , Gagne Katelyn , Beauchamp Ellen , Fogel Jonathan , Perlov Aleksej , Sola Mireia , Schlaeger Thorsten , Hofmann Inga , Shimamura Akiko , Ebert Benjamin L. , Schmitz‐Abe Klaus , Markianos Kyriacos , Murphy Kristi , Sun Liang , Rockowitz Shira , Sliz Piotr , Campagna Dean R. , Springer Timothy A. , Bahl Christopher , Agarwal Suneet , Fleming Mark D. , Williams David A.
Published: October 2021

Septins play key roles in mammalian cell division and cytokinesis but have not previously been implicated in a germline human disorder. A male infant with severe neutropenia and progressive dysmyelopoiesis with tetraploid myeloid precursors was identified. No known genetic etiologies for neutropenia or bone marrow failure were found. However, next‐generation sequencing of germline samples from the patient revealed a novel, de novo germline stop‐loss mutation in the X‐linked gene SEPT6 that resulted in reduced SEPT6 staining in bone marrow granulocyte precursors and megakaryocytes. Patient skin fibroblast‐derived induced pluripotent stem cells (iPSCs) produced reduced myeloid colonies, particularly of the granulocyte lineage. CRISPR/Cas9 knock‐in of the patient's mutation or complete knock‐out of SEPT6 was not tolerated in non‐patient‐derived iPSCs or human myeloid cell lines, but SEPT6 knock‐out was successful in an erythroid cell line and resulting clones revealed a propensity to multinucleation. In silico analysis predicts that the mutated protein hinders the dimerization of SEPT6 coiled‐coils in both parallel and antiparallel arrangements, which could in turn impair filament formation. These data demonstrate a critical role for SEPT6 in chromosomal segregation in myeloid progenitors that can account for the unusual predisposition to aneuploidy and dysmyelopoiesis.
Decentralized targeting control of collinear agents
Authors: Wu Jinze , Pu Weihua , Zhang Fan , Yu Wenwu
Published: October 2021

In this paper, we deal with the decentralized targeting control problem of collinear agents in three‐dimensional space. Here the direction half‐lines associated with these agents are not coplanar on the baseplane determined by the agents and the target at the very beginning. The two direction angles of each direction half‐line in a local polar coordinate frame associated with each agent are adopted to denote the direction of the corresponding agent. The two agents at the two ends are assumed to already point at the target and stay there. Only through local information exchanges with the left and right neighbors, the remaining agents regulate their own direction angles locally so that their direction half‐lines eventually point to the same target. All the agents and the target are stationary in the sense that their locations do not change. The crucial idea of our designed decentralized targeting control algorithm is to exploit the geometric relations of the direction angles and the relative distances among three neighboring agents. The regulation of the projection lines of the direction half‐lines is the critical step to the present three‐dimensional case from the two‐dimensional one. Finally, the decentralized targeting control problem is converted into a Lyapunov stability problem and resolved. The validity of the obtained theoretical results is illustrated through numerical simulations.
Recent progress on the study of multi‐vehicle coordination in cooperative attack and defense: An overview
Authors: Zhou Jialing , Wu Xiongjun , Lv Yuezu , Li Xiaodong , Liu Zhaohui
Published: October 2021

Cooperative guidance and control design of multiple vehicles plays an important role in obtaining benefits of cooperation for enhancement of combat effectiveness in modern military. A number of efficient cooperative strategies have been developed in literature within this context. This paper aims to provide a detail overview of the theoretical advances toward multi‐vehicle coordination for cooperative attack and defense. With a focus on the pertinent literature published in the past two decades, this topic is divided into two categories, namely, terminal‐time coordination and multiplayer pursuit‐evasion. The recent progress of these two categories is systematically reviewed, and a short discussion on future research perspectives is also presented.
Techno‐economic comparison of amine regeneration process with heat‐stable amine salt reclaiming units
Authors: Lim Jonghun , Lee Jesung , Moon Il , Cho Hyungtae , Kim Junghwan
Published: October 2021

Most factories employ an amine gas sweetening process to remove sulfur compounds. During this process, heat‐stable amine salt (HSAS) is generated, which reduces process efficiency. Ion exchange resin and electrodialysis reclamation methods are employed for HSAS removal. However, the equipment cost, electricity, water, and raw material consumption of each unit vary according to the amount of HSAS reclaimed; thus, it is necessary to consider the cost. In this study, we compared the techno‐economic aspects of the amine regeneration process for individual HSAS reclaiming units, developed process models to predict operation costs, and verified our simulation results by comparing actual operation and design data. The proposed mathematical models can be employed to calculate various costs incurred during amine regeneration with HSAS reclaiming units. The economic crossover point is derived at 36.6111 kg‐mol/d by utilizing the models. This enables economically feasible units to be identified based on the amount of HSAS reclaimed.
Cachexia index as a potential biomarker for cancer cachexia and a prognostic indicator in diffuse large B‐cell lymphoma
Authors: Go Se‐Il , Park Mi Jung , Park Sungwoo , Kang Myoung Hee , Kim Hoon‐Gu , Kang Jung Hun , Kim Jung Hoon , Lee Gyeong‐Won
Published: October 2021

Background

Cancer cachexia is known to adversely affect the clinical course in patients with malignant lymphoma. The cachexia index (CXI) is a potential biomarker of cancer cachexia, and its implications for the prognosis and treatment outcome of lung cancer and aggressive lymphoma has been assessed in previous studies.

Methods

A total of 267 patients diagnosed with diffuse large B‐cell lymphoma who were treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R‐CHOP) immunochemotherapy were retrospectively reviewed. The CXI was calculated as the skeletal muscle index (SMI) × serum albumin/neutrophil–lymphocyte ratio (NLR). Although previous studies measured the SMI using the muscles of the L3 vertebral level, the present study used both the L3 vertebral muscles and the pectoralis muscles (PM) at the T4 vertebral level to measure the SMI. Depending on the type of muscles used, the CXI was termed the L3‐CXI or PM‐CXI. Using sex‐specific cutoff values for CXI, the patients were categorized as follows: (i) high‐CXI group (high L3‐CXI and high PM‐CXI), (ii) intermediate‐CXI group (high L3‐CXI and low PM‐CXI), and (iii) low‐CXI group (low L3‐CXI and low PM‐CXI).

Results

Complete responses to R‐CHOP were obtained in 145/173 (83.8%), 25/36 (69.4%), and 27/57 (47.4%) patients in the high‐CXI, intermediate‐CXI, and low‐CXI groups, respectively (P < 0.001). Treatment‐related anaemia (15.6%, 30.6%, and 26.3%, P = 0.038), thrombocytopenia (21.4%, 36.1%, and 43.9%, P < 0.001), febrile neutropenia (23.7%, 44.4%, and 36.8%, P = 0.022), and any nonhaematologic toxicity (31.2%, 44.4%, and 54.4%, P = 0.001) of Grade 3 or more were more common in the lower CXI groups than in the higher‐CXI groups. Early treatment discontinuation for reasons other than lymphoma progression also occurred more frequently in the low‐CXI group (24/57, 42.1%) compared with the intermediate‐CXI (5/36, 13.9%) and high‐CXI (18/173, 10.4%) groups (P < 0.001). Median overall survival in the high‐CXI, intermediate‐CXI, and low‐CXI groups was not reached, 50.6 months, and 14.5 months, respectively (p < 0.001). Multivariable analysis showed that low CXI was an independent negative prognostic factor for overall survival (hazard ratio 2.103, 95% confidence interval 1.278–3.460, P = 0.003).

Conclusions

We suggest that in patients with diffuse large B‐cell lymphoma, the CXI is a biomarker for cancer cachexia that can predict survival, treatment response, treatment‐related toxicity, and compliance with R‐CHOP. Patients were more clearly stratified by this new CXI category compared with the classifications described in previous studies.