bluuebunny/crossref_metadata_2025 huggingface dataset:
THE STATUS OF TOPOGRAPHIC MAPPING IN THE WORLD A UNGGIM–ISPRS PROJECT 2012–2015
Authors: Konecny G. , Breitkopf U. , Radtke A.
Published: June 2016

Abstract. In December 2011, UNGGIM initiated a cooperative project with ISPRS to resume the former UN Secretariat studies on the status of topographic mapping in the world, conducted between 1968 and 1986. After the design of a questionnaire with 27 questions, the UNGGIM Secretariat sent the questionnaires to the UN member states. 115 replies were received from the 193 member states and regions thereof. Regarding the global data coverage and age, the UN questionnaire survey was supplemented by data from the Eastview database. For each of the 27 questions, an interactive viewer was programmed permitting the analysis of the results. The authoritative data coverage at the various scale ranges has greatly increased between 1986 and 2012. Now, a 30 % 1 : 25 000 map data coverage and a 75 % 1 : 50 000 map data coverage has been completed. Nevertheless, there is still an updating problem, as data for some countries is 10 to 30 years old. Private Industry, with Google, Microsoft and Navigation system providers, have undertaken huge efforts to supplement authoritative mapping. For critical areas on the globe, MGCP committed to military mapping at 1 : 50 000. ISPRS has decided to make such surveys a sustainable issue by establishing a working group.
Bridging the Gap between Observational Oceanography and Users
Authors: Eschenbach Christiane A.
Published: June 2016

Abstract. In order to ensure relevance and societal impact of research and to meet the various requirements of different target groups the Coastal Observing System for Northern and Arctic Seas (COSYNA) developed and pursued a broad range of activities for knowledge transfer and stakeholder interaction. Potential user groups of data and data products include, but are not limited to science, administration, renewable energies, engineering, tourism, and nature conservation. COSYNA data and data products are publicly accessible and available free of charge via the Internet (data portal, www.cosyna.de). The stakeholder interaction is integrated into the COSYNA product life cycle outlined here and the steps undertaken are exemplified for the product “Surface Current Fields in the German Bight”: Initial surveys revealed COSYNA’s potential relevance in the national and international context. After the mathematical-technological realisation of high quality parameter fields, external experts evaluated the scientific value, informational value, innovative leap, cost/benefit aspects, operability etc. of the data products. In order to improve products and their usability and to pave the way for future co-operation, interviews and workshops with potential users from the offshore wind energy industry were conducted. The stakeholder interaction process was successful, revealing relevant insights into user demands and usability of (possible) products. Analysis of data download provided some evidence for impact beyond academia. Other criteria for the increasingly demanded evaluation of impact of coastal research are discussed. By sharing first hand experiences this study contributes to the emerging knowledge on integration of science and end-users.
Seasonal resonance of diurnal coastal trapped waves in the southern Weddell Sea, Antarctica
Authors: Semper Stefanie , Darelius Elin
Published: June 2016

Abstract. The summer enhancement of diurnal tidal currents at the shelf break in the southern Weddell Sea is studied using velocity measurements from 29 moorings during the period 1968 to 2014. Kinetic energy associated with diurnal tidal frequencies is largest at the shelf break and decreases rapidly with distance; its magnitude increases from austral winter to summer by on average 50 %. The summer enhancement is observed in all deployments. The observations are compared to results from an idealised numerical solution of the properties of coastal trapped waves (CTWs) for a given bathymetry, stratification and an along-slope current. The frequency at which the dispersion curve for mode 1 CTWs displays a maximum (i.e. where the group velocity is zero and resonance is possible) is found within or near the diurnal frequency band, and it is sensitive to the stratification in the upper part of the water column and to the background current. The maximum of the dispersion curve is shifted towards higher frequencies, above the diurnal band, for low stratification and a strong background current (i.e. winter-like conditions) and towards lower frequencies for strong upper layer stratification and a weak background current (summer). The seasonal evolution of hydrography and currents in the region is inferred from available mooring data and conductivity-temperature-depth profiles. Near-resonance between CTWs and the diurnal tides during austral summer can explain the observed seasonality in tidal currents.
Operational algae bloom detection in the Baltic Sea using GIS and AVHRR data
Authors: Kulawiak Marcin
Published: June 2016

During the blooming season, algal colonies can, in extreme cases, cover up to 200 000 square kilometres of the Baltic Sea water surface. Because the position and shape of the blooms may significantly change in a very short time due to the influence of wind and waves, regular monitoring of the blooms’ development is necessary. Currently, the desired monitoring frequency may only be achieved by means of remote sensing. The article presents a novel method of AVHRR data processing for the purpose of detection of algal blooms in the Baltic Sea. Instead of analysing the value of spectral reflectance of the algae, the algorithm analyses the frequency distribution of normalized difference in reflectance between the visible and near-infrared spectral bands. The proposed method has been implemented and tested as part of an operational Geographic Information System.
El humor gráfico español ante el referéndum escocés del 18 de septiembre de 2014 ¿Dibujando la independencia de Cataluña?
Authors: Requejo Fraile Marta , Velasco Molpeceres Ana María , Reguero Sanz Itziar
Published: June 2016

El presente artículo analiza el discurso que los principales diarios españoles dieron al referéndum por la independencia de Escocia, celebrado el 18 de septiembre de 2014, a través del humor gráfico. Mediante el Análisis Textual, el objetivo primordial de este estudio es examinar el tratamiento informativo que realizaron El País, El Mundo, ABC, La Razón, La Vanguardia y El Periódico por medio de sus viñetas de opinión. Esta investigación presenta un campo novedoso de análisis tanto en el tema, abriendo nuevas áreas de trabajo sobre el nacionalismo y el papel de los medios, como en la metodología, pues el examen del humor gráfico continúa siendo una asignatura pendiente en los estudios de comunicación.
Representar lo irrepresentable: las fotografías de Lee Miller en Buchenwald y Dachau
Authors: Sáez de Urabain Ainara Miguel
Published: June 2016

Este artículo propone una reflexión en torno a lo que el historiador Saul Friedländer dio en llamar “los límites de la representación” de las masacres y los genocidios, con el objetivo de aportar pruebas que contribuyan a zanjar el viejo debate sobre la irrepresentabilidad del Holocausto. Para lograrlo, se realizará un análisis textual de cinco de las imágenes más dolorosas que la fotógrafa americana Lee Miller realizara en los campos de concentración nazis de Buchenwald y Dachau, en abril de 1945. La corresponsal de guerra, quien llegó a ser asistente de fotografía, musa y amante de Man Ray, presenció el horror, y si supo representarlo fue, en gran parte, gracias a su mirada surrealista.
Família e poder nos espaços de trabalho e das trajetórias urbanas
Authors: Silva Ari Rocha da
Published: June 2016

A concepção deste trabalho tem como fonte de reflexão a pesquisa de doutoramento a qual objetiva interpretar a dinâmica das ações sociais de sujeitos que executam o trabalho de catação de materiais recicláveis na cidade de Passo Fundo, polo regional e econômico do norte do estado do Rio Grande do Sul. Temos como hipótese de pesquisa que os catadores são atores sociais dinâmicos na medida em que integram as políticas públicas e sociais postas pelo Estado, ao mesmo tempo em que são sujeitos táticos e estratégicos na promoção de seus interesses, assim como exercem uma capacidade de subjetividade condicionada culturalmente. A primeira etapa do levantamento de dados do estudo se constituiu em uma fase exploratória do campo de análise, com a aplicação de questionário socioeconômico junto a 120 catadores em diferentes locais da cidade. A segunda etapa está sendo executada, estão previstas 20 entrevistas narrativas com tal segmento de trabalhadores urbanos. Ao implementar os levantamentos de dados (questionários e entrevistas), constatou-se a importância das relações familiares e parentais na constituição de diferentes grupos de trabalho, visto o caráter positivo dos aportes de poder, confiança e reciprocidade utilizados pelos trabalhadores, seja em âmbito formal, em cooperativas de trabalho, seja no âmbito considerado informal, utilizando os espaços das ruas e das casas como ambiente de organização das atividades laborais cotidianas.
Feliz daquele que arranja um bom emprego: trajetórias geracionais no trabalho e acesso e educação de famílias sergipanas em Santos
Authors: Conceição Danilo Alves da
Published: June 2016

Tendo o porto como importante atividade econômica e palco fundamental da chegada das grandes levas de imigrantes no Brasil no início do século passado, a cidade de Santos tem o fenômeno migratório como elemento inerente à sua história. Dentre as mais variadas origens que compõem a população santista, destaca-se a presença maciça de migrantes nordestinos oriundos do Estado de Sergipe. A pesquisa em desenvolvimento do qual este artigo é um desdobramento, tem como objetivo geral investigar as transformações nas trajetórias ocupacionais e de escolaridade de migrantes oriundos do Estado de Sergipe residentes na cidade de Santos. Proponho a partir da trajetória de uma família de migrantes sergipanos composta por três gerações uma reflexão acerca do fluxo migratório entre Santos e o município sergipano de Macambira. Posteriormente busco compreender através dos relatos e da contribuição teórica de Pierre Bourdieu, Richard Sennett entre outros, como as categorias trabalho e educação se modificam, relacionam ou não, de uma geração para outra e qual o papel desempenhado pela unidade familiar neste processo.
Polêmicas do Tribunal de Contas do Paraná em 2015
Authors: Pereira Fernando Marcelino
Published: June 2016

Polêmicas do Tribunal de Contas do Paraná em 2015
TAKATUZI, Tatiana. Águas bastismais e santos óleos: uma trajetória histórica do Aldeamento de Atalaia. Curitiba: SAMP, 2014. 228 p.
Authors: Ferrari Adriane Dos Santos Tavella
Published: June 2016

TAKATUZI, Tatiana. Águas bastismais e santos óleos: uma trajetória histórica do Aldeamento de Atalaia. Curitiba: SAMP, 2014. 228 p.
PIERUCCINI, Maria Cristina. Os Rocha Loures: uma família paranaense em 300 anos de história. Curitiba: Posigraf, 1995. 204p
Authors: Vanali Ana Crhistina
Published: June 2016

PIERUCCINI, Maria Cristina. Os Rocha Loures: uma família paranaense em 300 anos de história. Curitiba: Posigraf, 1995. 204p
Família Slaviero: uma história de grandes conquistas
Authors: Goulart Monica Helena Harrich Silva
Published: June 2016

O presente texto tem como objetivo inicial apontar a trajetória do Grupo Slaviero por meio da história de seus negócios empresarias. Percebe-se a consolidação da família como um dos sobrenomes mais importantes do Paraná, aspecto evidenciado por meio da genealogia. Desde as atividades iniciadas com o patriarca Fioravante Slaviero a família vem se destacando de forma cada vez mais presente em vários seguimentos.
RECONHECIMENTO E ORGANIZAÇÃO DAS RELIGIÕES AFRO-BRASILEIRAS NUMA CIDADE DE COLONIZAÇÃO GERMÂNICA
Authors: Machado Gerson
Published: June 2016

Neste artigo apresento reflexões sobre a construção de um saber-poder a respeito das religiões afro-brasileiras em Joinville/SC, cidade que ocupa papel de destaque no processo de ocupação europeia no Sul do Brasil, mas que acolheu outras identidades em seu território, desde meados do século XIX. É uma reflexão historiográfica que problematiza a teia constituidora das dizibilidades inerentes ao estabelecimento dessas religiões no cenário da cidade, nas décadas finais do século XX, apontando para estratégias de consolidação dos grupos e para as críticas às fontes utilizadas na construção do saber historiográfico. Neste cenário, as fontes orais exigem do historiador uma sensibilidade específica para valorar e sistematizar narrativas, aparentemente desconexas, as quais, associadas às outras formas de enunciação, conferem sentidos à realidade, distintos daqueles sustentados pelo “status quo”. Diante disso, espaço, tempo e narrativa são fenômenos de uma trama em que essas agremiações religiosas a um só tempo reivindicam o direito ao pertencimento à cidade ao mesmo tempo em que reafirmam que a realidade social é consolidada na e pelas diferenças.
EDITORAL DA SEÇÃO TEMÁTICA
Authors: Machado Gerson
Published: June 2016

EDITORIAL DA SEÇÃO TEMÁTICA:FENÔMENO RELIGIOSO DE MATRIZ AFRO-BRASILEIRA
Teoria dos precedentes à brasileira e a destemporalização da decisão jurídica
Authors: Lopes Saldanha Jânia Maria , Hoffmam Fernando , Salvadori Gracia Thaís
Published: June 2016

A cultura jurídico-decisória brasileira vem marcada por uma reprodução aconteudística de enunciados sumulares descontextualizados em relação ao caso concreto e, com isso, fora do tempo, fora do mundo. Tal cultura nasce ligada umbilicalmente ao paradigma político-econômico neoliberal que busca a construção de um mercado de decisões para o mercado, marcadas pelo congelamento conteudístico da decisão jurídica, sob o pretexto de dando segurança ao decidir, acelerar o processo decisório. No entanto, em meio ao paradigma do Estado Democrático de Direito é mister decidir com os olhos no caso concreto e na mundanidade que o circunda. Dessa forma, propõe-se a construção de um espaço-tempo jurídico-decisório de integridade e coerência que leve a sério o caso concreto, assentado em uma teoria da decisão jurídica hermeneuticamente adequada ao seu tempo.
O império como conflito: Chalmers Johnson e a política externa norte-americana
Authors: Pinto Roberto Bueno
Published: June 2016

Este artigo visa analisar a noção de conflito em sua projeção nas relações internacionais a partir da ótica de Chalmers Johnson, ancorando a argumentação em uma interpretação antropológica e geopolítica da função de poder, especialmente focando a análise das relações de poder estabelecidas pelo balizamento da alta tensão exercida pela política externa norte-americana. Partindo desta contextualização teórica, este artigo assume como seu objeto a ideia de que a crítica de Johnson encontra-se centralizada não em uma perspectiva política do imperialismo mas, isto sim, econômica.
Perspectivas y perfiles de la cultura y el pacto de los derechos económicos, sociales y culturales a la luz de la fe y la justicia
Authors: Rocasolano María Méndez
Published: June 2016

Se reflexiona sobre el significado y alcance de los derechos culturales expresados en el artículo 15 del Pacto Internacional de Derechos Económicos, Sociales y Culturales (PIDESC), revisando su precedente inmediato, el art 27 de la Declaración de los Derechos Humanos a la luz de la Dialéctica de los Derechos Humanos y la Doctrina Social de la Iglesia. A continuación se estudian las influencias recibidas desde la UNESCO, brevemente las Declaraciones regionales, europeas americanas asiáticas y africanas y las aportaciones de las Constituciones del ámbito cultural hispano-luso-americano y la aportación de la Doctrina Social de la Iglesia a los derechos y obligaciones culturales. En el punto tercero se analiza el Protocolo facultativo del Pacto de Derechos Económicos Sociales y Culturales especialmente el nuevo procedimiento para la eficacia y el cumplimiento de los derechos culturales. Finalmente se concluye poniendo de manifiesto la necesidad de superar el carácter de soft law del Pacto debido a que la propia naturaleza de los derechos culturales en cuanto derechos humanos vinculados a la dignidad de la persona, exigen su real y universal respeto, protección y garantía.
A relevância do afeto e da alteridade na garantia dos direitos humanos
Authors: Hogemann Edna Raquel
Published: June 2016

Este ensaio se propõe a refletir sobre a importância dos conceitos de afeto e alteridade como elementos garantidores da efetividade dos Direitos Humanos na pós-modernidade, e na análise crítica acerca da ausência da prática da alteridade nas relações intersubjetivas na sociedade contemporânea. Dessa forma, a partir da leitura de autores como Fromm, Bauman, Birman, Lèvinas e outros, o estudo objetiva, ainda que sem esgotar o tema, promover uma investigação acerca de suas contribuições para a superação de um cenário em que o agir social se traduz numa prática impessoal, não dialógica, centrada na figura do eu logocêntrico. Para tanto, partir-se-á do que se identifica como cerne do problema: a crítica da modernidade, em especial do individualismo exacerbado que tende ao desrespeito aos direitos fundamentais da pessoa humana, para a seguir, discorrer sobre a relevância do afeto e de uma ética com base na alteridade como formas superação e transcendência na busca da efetividade dos Direitos Humanos. O texto finda por apontar que se os indivíduos têm sido continuamente condicionados a manter-se extremamente fixados na valorização das suas diferenças individuais como força, inteligência, raça, gênero, poder etc, somente através de uma mudança paradigmática ancorada na alteridade e amalgamada pelo afeto será possível vislumbrar uma saída que garanta o direito do ser humano de ser igual quando a diferença inferioriza e diferente quando a igualdade deprecia.
Direitos humanos fundamentais das pessoas com deficiência
Authors: Oliveira da Silveira Vladmir
Published: June 2016

Este artigo versa sobre os direitos humanos fundamentais das pessoas com deficiência, sob a perspectiva do processo de dinamogenesis de direitos. Por se tratar de um estudo descritivo e exploratório, será realizado com base na pesquisa bibliográfica e histórica, utilizando-se por vezes do método dedutivo e, outras vezes, do indutivo, principalmente nas críticas e reflexões acerca dos textos normativos. A terminologia “direitos humanos fundamentais” se justifica na ideia de complementariedade entre as tutelas nacional, regional e universal desses direitos, constatado o fato de que há direitos humanos que são constitucionalizados e direitos humanos fundamentais que são internacionalizados, podendo-se afirmar a primazia dos direitos humanos fundamentais, tanto no âmbito nacional quanto no internacional. Nesse sentido, este artigo analisa a tutela jurídica das pessoas com deficiência em três níveis: internacional, regional e nacional, traçando um diálogo entre os níveis de proteção, à luz da teoria do Estado Constitucional Cooperativo, de Peter Häberle. Em relação ao nível nacional de proteção das pessoas com deficiência, discutem-se os fundamentos e as consequências em se conferir hierarquia normativa infraconstitucional, supralegal ou constitucional, bem como problematiza a hipótese da não aprovação das novas convenções sobre direitos humanos segundo o rito previsto no artigo 5º, § 3º, da Constituição Federal.
A influência positivista em São Paulo nos primórdios da República: memórias do progresso e da pobreza associada ao higienismo
Authors: Oliveira Sobrinho Afonso Soares
Published: June 2016

O pensamento do progresso nos primórdios da República em São Paulo era associado às ideologias de higiene e limpeza social. Nesse contexto as memórias do progresso material da época revelam as medidas de disciplinamento da pobreza enquanto constituidora de uma utopia burguesa de uma nova ordem social.
Reflexões sobre técnica e Direito
Authors: Ormelesi Vinicius Fernandes
Published: June 2016

Este trabalho analisa o Direito sob a perspectiva da técnica. Parte-se da concepção do filósofo e sociólogo francês Jacques Ellul. O objeto do estudo é direcionado no âmbito jurídico ao Judiciário e à aplicação das normas. Com esse viés analisam-se os desdobramentos da técnica no fenômeno jurídico, na medida em que a sociedade se torna mais tecnocrática. Utiliza-se do método dedutivo com análise bibliográfica da obra do autor. Pretende-se com esse exame ponderar se existe uma crise da Justiça provocada pela técnica, mercê do império do Direito.
Violações de Direitos Humanos no Brasil: notas a partir do 5º Relatório Nacional de Direitos Humanos
Authors: Costa Gustavo Gomes da , Cardoso Fernando Da Silva , Cavalcanti Gabriela Guimarães
Published: June 2016

O presente estudo visa discorrer acerca do atual quadro de violações dos direitos humanos no panorama brasileiro contemporâneo, tendo, como lócus, os dados apresentados pelo 5º Relatório Nacional sobre os Direitos Humanos (RNDH) no Brasil, oriundo do Núcleo de Estudos da Violência da Universidade de São Paulo (BRASIL, 2012). Para tanto, este artigo pretende, a partir de um estudo documental, traçar um panorama que ofereça informações quanto à proteção dos Direitos Humanos no Brasil, considerando, para tanto, as questões centrais detectados a partir da análise do referido mapeamento presente no 5º RNDH. O trabalho buscou apresentar algumas construções sobre determinados aspectos, quais sejam: (i) o mapeamento das principais violações de direitos humanos no Brasil; (ii) os entraves quanto a (des)articulação normativa; e, (iii) a (in)efetividade de direitos na ordem jurídico-política brasileira e sua relação com a fragilidade de políticas públicas.
La prisión preventiva: interpretando su estructura
Authors: Kostenwein Ezequiel
Published: June 2016

En el presente trabajo haremos una breve introducción a la definición de la prisión preventiva (en adelante, PP), junto a una serie de trabajos en los que se la estudia dentro de contextos tres relacionados entre sí: América Latina, Argentina y la Provincia de Buenos Aires (en adelante, PBA). Posteriormente, mencionaremos a dos actores que intervienen en la estructuración del problema de la PP por afuera del Poder Judicial (en adelante, PJ): los medios de comunicación y las autoridades políticas.
O sigilo fiscal e a Lei de acesso à informação: possibilidades de acesso à informação administrativa fiscal
Authors: Machado Edinilson Donizete , Janini Tiago Cappi
Published: June 2016

Resumo: Este artigo destina-se a analisar a possibilidade de o contribuinte acessar as informações administrativas fiscais que lhe dizem respeito em poder da Administração Fazendária. Baseado em uma pesquisa bibliográfica, legislativa e jurisprudencial, este estudo utiliza-se do método dedutivo e do procedimento analítico, e tem por objetivo examinar o trato da informação administrativa fiscal, especialmente com a evolução do ciberespaço. Dessa forma a abordagem parte da identificação da informação administrativa, principalmente com o advento da Lei nº 12.527/11, e, após relacionar a fiscalização tributária com os direitos fundamentais do contribuinte, conclui que o Poder Público não pode negar ao contribuinte o acesso ao banco de dados sob pena de violar direitos fundamentais constitucionalmente previstos. Aponta, por fim, o habeas data como instrumento processual adequado para proteger o direito de o contribuinte obter as suas informações fiscais.
Identification of Ephedra species by phylogenetic analyses using matK and ITS1 sequences
Authors: Zhao Yun Sheng , Xie Li Xia , Mao Fu Ying , Cao Zhe , Wang Wen Ping , Zhao Qi Peng , Zhang Xin Hui
Published: June 2016

In this study, the species identifications of seven Ephedra plants, including three medicinal plants from the Pharmacopoeia of the People’s Republic of China, were conducted using phylogenetic analyses, and the method’s validity was verified. The phylogenetic trees constructed from the maturase-coding gene (matK) and internal transcribed spacer 1 (ITS1) sequences showed that the former could be used for identifying five Ephedra plants, Ephedra intermedia, E. equisetina, E. antisyphilitica, E. major, and E. aphylla, but it had less power to discriminate E. sinica and E. przewalskii, while the latter could distinguish five Ephedra plants, E. przewalskii, E. equisetina, E. antisyphilitica, E. major, and E. aphylla, but it had less power to discriminate E. sinica and E. intermedia. However, when the two genes were combined, the seven species could be completely distinguished from each other, especially the medicinal plants from the others, which is significant in developing their pharmaceutical uses and in performing quality control assessments of herbal medicines. The method presented here could be applied to the analysis of processed Ephedra plants and to the identification of the botanical origins of crude drugs. Additionally, we discovered that E. equisetina and E. major were probably closely related to each other, and that E. sinica, E. intermedia, and E. przewalskii also had a close genetic relationship.
Development of poorly differentiated invasive squamous cell carcinoma in giant Bowen’s disease: a case report with dermatoscopy
Authors: Akay Bengu Nisa , Maden Aysenur , Kocak Oguzhan , Bostanci Seher , Boyvat Ayse , Kocyigit Pelin , Heper Aylin Okcu
Published: June 2016

Bowen’s disease (BD) is an in situ form of squamous cell carcinoma (SCC), often occurring in the chronically UV-damaged skin of elderly people. The risk of progression of BD to invasive SCC varies between 3% and 5%, and one-third of invasive tumors may metastasize. Herein we discuss the dermatoscopic findings of a case of giant Bowen’s disease, which progressed to poorly differentiated invasive SCC.
A complicated fever
Authors: Ghiringhelli Paolo , Aspesi Mariagrazia
Published: June 2016

Fever of unknown origin is a common problem in medical practice and assemble a broad spectrum of diagnostic possibilities. We report a case of a 24-year-old woman with high-spiking fever. A diagnosis of adult-onset Still’s disease (AOSD) was made. This is a rare inflammatory disease with an unknown aetiology. The diagnosis of adult-onset Still’s disease can be very difficult. There are no specific tests and reliance is usually placed on a symptom complex and the well described typical rash seen in most patients. Thus, the diagnosis is made by exclusion and with the help of diagnostic criteria. The treatment of this disease has to limit the intensity of the symptoms, and this is usually obtained with NSAIDs (NonSteroidal Anti-Inflammatory Drugs), and to control the disease evolution, through the use of corticosteroid, methotrexate or ciclosphorine A. In the case here described treatment with corticosteroid met with a good response.
Clinical management of anasarca
Authors: Talarico Francesca , Galasso Domenico
Published: June 2016

Anasarca is a medical symptom characterized by widespread swelling of the organism due to effusion of fluid into the extracellular space. It is usually caused by either cardiac failure, liver failure or renal failure and requires hospitalization and in-depth investigations. We report a case of a 51-years-old woman, with recent recidivation of cutaneous tumour, hospitalized for basal left pneumonia treated with antibiotic therapy, with regression of the radiological signs but progressive appearance of generalized oedema, whose complex differential diagnostic procedure made evident the presence of crioglobulinemic glomerulopathy and vasculitis in patient with chronic HCV correlated liver disease. The case imposed the careful evaluation of the therapeutic strategy, for the coexistence of autoimmune pathology and of HCV positiveness in patient with recent neoplastic recidivation
When eczema stay home
Authors: Pugliese Antonio
Published: June 2016

Although most visits for skin disease are managed by primary care physicians, diagnosis and treatment of skin disease are often difficult for family doctors. In this article, two cases of occupational allergic contact dermatitis in ironers are presented. Both patients only developed their dermatitis when they came into contact with formaldehyde. Occupational dermatitis are very frequent with important social and economic implications: thus, they represent a therapeutic challenge non only for dermatologists, but also for family doctors.
A case of peripartum heart failure
Authors: Vinci Annalisa , Caforio Alida
Published: June 2016

A 32-year-old woman was admitted in congestive heart failure (CHF) 3 days after delivery. She had no history of cardiovascular disease and impaired left ventricular Ejection Fraction (EF 35%). She underwent complete heart catheterisation, selective coronary angiography and right ventricular endomyocardial biopsy (EMB).Coronary arteries were normal and EMB revealed active virus negative myocarditis. Serum was positive for anti-heart autoantibodies (AHA). Thus myocarditis was classified as autoimmune and the patient was treated with immunosuppressive therapy, with clinical and hemodynamic improvement. At 27 months follow-up EMB showed healed myocarditis. Peripartum cardiomyopathy (PPCM) is a rare disorder in which left ventricular dysfunction and heart failure occur in the peripartum period in previously healthy women. The etiology is still unknown but a sizable proportion of patients may have an underlying organ-specific autoimmune myocarditis.
Celiac disease, rare symptoms, autoimmune patology
Authors: Volta Umberto , Parisi Claudia , Piscaglia Maria , Fabbri Angela , Fiorini Erica
Published: June 2016

We report a case of a 42-years-old woman with constipation, anemia and recurrent itch. After several investigations, celiac disease was diagnosed and a treatment with a gluten-free diet was applied with beneficial effects. Recognizing celiac disease can be difficult because some of its symptoms are similar to those of other diseases. In fact, sometimes it is confused with irritable bowel syndrome or iron-deficiency anemia or intestinal infections: as a result, celiac disease is commonly underdiagnosed or misdiagnosed. This case report is described to address the physician to a correct diagnosis of celiac disease.
A strange myalgia
Authors: Ghiringhelli Paolo
Published: June 2016

A 70-year-old man was admitted in our hospital with mild fever, pain, myalgia. His eosinophil count was high, leading to a diagnosis of hypereosinophilic syndrome. This case report gives rise to many questions regarding diagnosis and correct management of eosinophilic myopathies.
Short Bowel Syndrome: clinical management
Authors: Pironi Loris , Guidetti Mariacristina , Lanzoni Elisabetta , Pazzeschi Caterina , Corsini Catia
Published: June 2016

The management of a case of intestinal failure due to Short Bowel Syndrome (SBS) is described. Patients’ care needs an expert multidisciplinary approach. Published data have demonstrated that the lack of a specialist staff is a risk factor for patients’ death. The creation of networks linking non-specialist doctors with dedicated centers is recommended.
Can antiplatelet therapy after drug eluting stent become a problem?
Authors: Romano Michele
Published: June 2016

Many clinical trials demonstrate that demonstrate drug-eluting stents (DES) can improve procedural success in patients with acute coronary syndromes, with a remarkable reduction in the rate of restenosis. On the other hand, it has been shown that stenting can also increase the rate of thrombotic complications including stent thrombosis. We describe a case of a 62-yaers-old male with angina. Four weeks after the insertion of a drug-eluting stent, the patients was admitted to our Emergency Department with asthenia.
Role of docetaxel in the treatment of advanced gastric carcinoma
Authors: Scartozzi Mario , Galizia Eva , Bianconi Maristella , Berardi Rossana , Cascinu Stefano
Published: June 2016

With a median survival of 9-11 months, advanced gastric cancer represents one of the most aggressive neoplastic disease in western Countries. Radical surgery is considered the cornerstone for any curative procedure, however only a relatively small proportion of resected cases can be considered cured after surgery. In the last few years research data suggested that advanced gastric cancer can be classified into 2 distinct clinical categories: locally advanced (nonmetastatic, non resectable) and metastatic. While the therapeutic goal in the metastatic setting is palliation and survival improvement, in locally advanced cases one of the main goals of the treatment should be response with the aim to make resectable what was unresectable. The introduction of docetaxel for the treatment of advanced gastric cancer represented then a crucial step forward for the cure of this disease with an improvement in both survival and response rate. In this article we reviewed past and ongoing trials using docetaxel in gastric cancer with the aim to delineate a possible effective strategy for the treatment of this tumour
Serotonin reuptake inhibitors in Obsessive-Compulsive Disorder: antidepressant or antiobsessional agents?
Authors: Maina Giuseppe , Pessina Enrico , Aguglia Andrea , Bogetto Filippo
Published: June 2016

The recommended pharmacological agents for the treatment of Obsessive-Compulsive Disorder (OCD) are serotonin reuptake inhibitors (SRI), used also as antidepressant drugs. Nevertheless, the therapeutic profile of SRIs shows a lot of differences in OCD and in depression, as demonstrated in the trials here described. From a pharmacological point of view, antidepressant effect can be obtained with every monoamine reuptake inhibitor, whereas a predominant serotonin reuptake inhibition is required to result in an antiobsessive effect; moreover, adding pindolol to SSRI therapy, generate opposite effects on SSRI response latency. From a clinical point of view, the trials have highlighted differences in the following fields: response rate, therapeutic dose, response latency, response curve. Taken together, these findings suggest that SRIs have two different clinical properties, antiobsessional effect and antidepressant effect, that could be due to different mechanisms of actions: further studies have to be performed the better to understand the pathophysiology of OCD.
Clinical-epidemiological evaluation in overweight and obese patients after “DCD method” application
Authors: Conese Marina , Massiah Grace , De Cavi Piero Oberto
Published: June 2016

The article describes an experimental observation performed for 2 years on 200 patients: 150 female and 50 male between 25 and 65 years old, overweight with class I, II and III obesity (WHO classification). Patients with overt diabetic pathology and with “borderline” hyperglycemia, hypertriglyceridemia and hypercholesterolemia are subjected to “DCD method” (appropriate dietary education associated to New-Electrosculpture) in Bari (DCD office). The aim of the study is weight loss, with patients’ life quality improvement. What we have obtained is an ideal body weight recover without anti-obesity drug use, with maintenance of the results obtained for 18 months.
The role of docetaxel in the multimodal treatment of non-small cell lung cancer
Authors: De Sanctis Rita , D’Antoni Igina , Del Signore Ester , Gori Bruno , Longo Flavia
Published: June 2016

We report the case of a 53-year-old woman with brain metastatic Non-Small Cell Lung Cancer (NSCLC). Diagnosis was made during brain surgery. Brain metastases were treated both with surgery and radiotherapy. The chemotherapy schedule was cisplatin 75 mg/m2 and docetaxel 75 mg/m2 1q21 for up to six cycles. Toxicities encountered were easily manageable. Subsequent thoracic radiotherapy improved tumor response and quality of life.
Psychotic disorder and its characteristics in sex chromosome aneuploidies
Authors: Verri Annapia , Cremante Anna
Published: June 2016

Sex chromosome anomalies have been associated with psychoses. We report a patient with XYY chromosome anomaly who developed a paranoid psychosis. The second case deal with a 51-year-old woman affected by Turner Syndrome and Psychotic Disorder, with a prevalent somatic and sexual focus.
Unexpected spontaneous remission of HCV in a patient with chronic HIV infection
Authors: Manfredi Roberto
Published: June 2016

We report an exceptional case of resolution of HCV infection in a HIV-infected patient. The patient, a 49-year-old male with history of drugs addiction, suffered from an evolutive liver disease never treated with specific anti-HCV compounds during two decades. The case report highlights a rare phenomenon, seldom reported in medical literature (a PubMed search retrieved only 8 similar cases), and underlines the importance of a deeper investigation of all the virologic, immunological, pathogenetic, and therapeutic implications.
Octreotide therapy in a patient with lung microcytoma
Authors: Adua Daniela , Gori Bruno , Stumbo Luciano , Del Signore Ester , Longo Flavia
Published: June 2016

We report the case of a 51-year-old woman with limited Small Cell Lung Cancer (SCLC). Cytological diagnosis has been made by fibroscopy. Chemotherapy schedule was cisplatin 30 mg/mq and VP-16 100 mg/mq days 1,2,3 q21 as first line treatment. The serum levels of cromogranine A and NSE (Neuron-Specific Enolase) were higher than normal; for this reason we prescribed, together with chemotherapy, octreotide LAR 30 mg every 28 days. Associated toxicity was easily manageable. Subsequent thoracic and panencefalic prophylactic radiotherapy improved tumour response and quality of life. We continued octreotide LAR 30 mg every 28 days even after the end of chemotherapy, as a maintenance therapy, checking periodically serum levels of NSE and cromogranine A. No side effects were observed.
Efficacy of somatostatine analogues in survival and quality of life of a frail patient with poorly differentiated biliary neuroendocrine tumour
Authors: Alì Marco , D’Agostino Antonino , Todaro Alfio , Girlando Andrea , Ferrara Marcello , Aiello Rosanna
Published: June 2016

We describe the case of a 71-year-old woman with poorly differentiated neuroendocrine tumor of third distal biliary duct and osteolytic metastasis. The patient was evaluated as a third stage of Balducci’s criteria for the recognition of frailty. The patient received radiotherapy and octreotide LAR. This treatment allowed a good tumour progression rate (18 months), a good quality of life and a good survival (35 months). The case report describes the role of octreotide in the therapy of neuroendocrine tumours, and underlines the importance of a multidisciplinary management of cancer in frail patients.
Long lasting octreotide LAR therapy in non functioning pancreatic neuroendocrine carcinoma
Authors: Lolli Ivan , Logroscino Antonio , Vallarelli Simona , Monteduro Maria A. , Gentile Antonella , Troccoli Giuseppe
Published: June 2016

Non functioning endocrine pancreatic tumors (NF-PETs) have absent or low hormone secretion without symptoms and constitue ~60% of PETs. At diagnosis more than 50% of patients have liver metastases and almost 40% are not candidates for radical surgery because of either locally advanced disease or unresectable metastases. We described the case of a 47-year-old woman with a pancreatic carcinoma with secondarism in the liver not suitable for radical surgery. Histological test of liver metastases showed positivity for endocrine well-differentiated non functioning carcinoma expressing receptors for somatostatin with very low proliferation index (Ki67 < 2%). After this diagnosis she started a specific treatment with octreotide analogues which achieved durable stabilization of the disease.
Treatment of lung microcytoma with neuroendocrine differentiation in elderly patient
Authors: Bearz Alessandra , Lleshi Arben , Fratino Lucia , Venturini Silvia , Berretta Massimiliano , Tirelli Umberto
Published: June 2016

We describe the case of a 80-year-old patient with lung microcytoma and comorbidity (diabetes, COPD and hypertensive cardiomiopaty). To manage the complexity of the elderly patient with comorbidity, he was evaluated by a Comprehensive Geriatric Assessment (CGA). Radiotherapy and chemotherapy were excluded because of the low Performance Status of the patient. A treatment with octerotide LAR was administered, allowing a good clinical benefit.
A case of double leukemia: chronic myeloid leukemia intolerant to imatinib and chronic lymphocytic leukemia
Authors: Rocchi Miriana
Published: June 2016

Chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML) are the most common leukemias of the elderly. However, the sequential occurrence of CML followed by CLL in the same patient is extremely rare. We present a report of a 70-year-old man who developed CLL six years after the diagnosis of CML in molecular, cytogenetic and morphologic remission. The diagnosis of CLL is confirmed by peripheral lymphocytosis. The first line therapy in CML in chronic phase is still imatinib, but in the present case the patient was intolerant to imatinib, therefore he switched to nilotinib after few months.
Usefulness of mirtazapine in cancer patients
Authors: Pasquini Massimo , Berardelli Isabella , Craba Ambra
Published: June 2016

The rate of depression in the general population is estimated as high as 15% and is at least two to three times more common in patients with cancer. Due to the complexity and constraints of cancer care, depression is often under-recognised and under-treated. Antidepressants are the most commonly used medications, however among cancer patients there are few randomised trials comparing antidepressants to placebo. Mirtazapine is an effective antidepressant with unique and special mechanism of action characterised by high response and remission rates, relatively early onset of action and favourable side-effect profile. Several studies reported that mirtazapine has a receptor-binding profile that may be suitable for use in controlling appetite loss and nausea of cancer patients. We conducted a review of the literature on the use of mirtazapine in cancer patients. We evaluated the effectiveness of mirtazapine for the management of depressive and anxiety symptoms and for several distressing symptoms such as pain, nausea, appetite loss, and sleep disturbances.
A complicated case of atrial fibrillation
Authors: Delsignore Erica , Cantone Roberto , Moia Maria Luisa , Olivetto Luigi , Pollo Maria Cristina , Varese Anna Maria , Tua Aldo , Bertoncelli Maria Cristina
Published: June 2016

Atrial fibrillation, usually considered a benign arrhythmia, recognizes several aetiologies: not only sctructural cardiopathies, but also other diseases, drugs intake or post-operative courses. Sometimes it can occur in absence of apparente cause. More and more frequently it is usual to consider this arrhythmia like a marker of pathological unknown situation; therefore, also patients with “lone atrial fibrillation” should be submitted to surveys in order to find probable associated causes.
A case of refractory ascites
Authors: Varvello Loris , Arnò Celeste , Bosio Angelo , Cerrato Flavio , Monaco Gabriele , Pascale Claudio
Published: June 2016

We describe a case of patient with alcoholic cirrhosis and severe functional hepatic impairment (Child C), developing in the last months renal impairment too and ingravescent, refractory ascites, despite high-dose diuretics. The patient was treated with intravenous albumin and, at last, weekly paracentesis. In this report we evaluate alternative therapeutic options (Transjugular Inrtahepatic Protosystemic Shunt, Orthotopic Liver Transplantation) when frequent paracentesis are needed.
Thromboembolic disease and chronic obstructive pulmonary disease
Authors: Re Roberta
Published: June 2016

Venous thromboembolism is still a leading cause of mortality and morbidity for hospitalised patients. While the awareness of the risk for thromboembolic complications for surgical patients is high, and effective prophylactic treatment is normally and systematically prescribed, the situation is very different regarding patients admitted in a internal medical ward. Only recently the usefulness of prophylactic treatment was recognised also for medical patients. A thromboembolic event can be a life threatening complication especially for people affected by chronic obstructive pulmonary disease (COPD) that represents a significant part of medical hospitalised patients. Moreover symptoms and signs related to the chronic pulmonary disease can be confusing factors that may delay a timely and correct diagnosis of a thromboembolic complication.
A “strange” case of COPD
Authors: Massarelli Laura , Tomaselli Valerio , Bussolino Carlo , Saracco Valter
Published: June 2016

Common variable immunodeficiency (CVID) is a rare syndrome, characterized by hypogammaglobulinemia and limited antibody responses due to either impaired B-lymphocyte development or B-cell responses to T-lymphocyte signals. CVID is frequently associated with bacterial infections, particularly against respiratory tract, that could determine a permanent organ damage (COPD, asthma), increased incidence of both autoimmune diseases and cancer, high prevalence of gastrointestinal inflammatory diseases (ulcerative colitis, Crohn’s disease, celiac disease), lymphoproliferative and granulomatous diseases. Given that the gastrointestinal tract is the largest lymphoid organ in the body, it’s not surprising that intestinal diseases are common in immunodeficiency. CVID is considered a congenital condition but it is usually diagnosed in adulthood. We describe the case of a 43-year-old man affected by recurrent infections of respiratory tract with CVID, celiac disease and type 1 diabetes. With the exclusion of gluten from the diet, patient achieved an improvement of serum level of immunoglobulins and a reduction of recurrent infections. This fact suggests that the interruption of the gluten stimulus could have a positive influence on the other diseases, improving the metabolic compensation and stabilizing the immune system.
A case of aspirin-resistance probably related to glycemic excursion
Authors: Fava Ilaria , Marfella Raffaele , Paolisso Giuseppe , Rizzo Maria Rosaria
Published: June 2016

Diabetes is characterised by development of specific microvascular complications and by a high incidence of accelerated atherosclerosis. Several Authors demonstrated that post-prandial hyperglycaemia is certainly an independent risk factor of vascular complications in type 2 diabetes. The endothelial dysfunction, the oxidative stress, the post-prandial hyperglycaemia and the haemostatic and thrombotic parameters alterations are the principal causes for the cardiovascular risk increase in diabetic patient. For this reason many studies on anti-platelet therapy have been made in order to reduce thrombotic complication of diabetes mellitus. However, data suggest that the clinical efficacy of low-dose aspirin in patients with diabetes is substantially lower than in individuals without diabetes. Indeed, several evidences support the hypothesis that diabetes might represent a case of “aspirin resistance”.
University Medicine in Italy: an exemplary “case report” of several unresolved criticities
Authors: Manfredi Roberto
Published: June 2016

The present role, space, task, mission, function, and outcome of University Medicine in Italy are briefly examined, taking as a pure and trivial pretext the actual professional activity of single, representative physician who changed his role at the same specialistic Department of the same University Hospital, by covering an University role in the past five years, after working at the same facility as an Hospital-affiliated specialist in charge of the same Medical Division during the previous 14 years. The lights and shadows of assistential and academic medicine organisation and integration in Italy are the starting point of our preliminary observations, which may be potentially extended to the University Medicine as a whole, from an organisative, functional, and especially ergonomic point of view.