bluuebunny/crossref_metadata_2025 huggingface dataset:
NIR‐II‐Responsive Hybrid System Achieves Cascade‐Augmented Antitumor Immunity via Genetic Engineering of Both Bacteria and Tumor Cells
Authors: Dai Xiaoguang , Liu Zhiwen , Zhao Xiaoyi , Guo Kangli , Ding Xiaokang , Xu Fu‐Jian , Zhao Nana
Published: August 2024

The combination of nanoparticles and tumor‐targeting bacteria for cancer immunotherapy can overcome the shortcomings of poor nanoparticle accumulation, limited penetration, and restricted distribution. However, it remains a great challenge for the hybrid system to improve therapeutic efficacy through the simultaneous and controllable regulation of immune cells and tumor cells. Herein, a hybrid therapeutic platform is rationally designed to achieve immune cascade‐augmented cancer immunotherapy. To construct the hybrids, photothermal nanoparticles responsive to light in the second near‐infrared (NIR‐II) region are conjugated onto the surface of engineered bacteria through pH‐responsive Schiff base bonds. Taking advantage of the hypoxia targeting and deep penetration characteristics of the bacteria, the hybrids can accumulate at tumor sites. Then nanoparticles detach from the bacteria to realize genetic engineering of tumor cells, which induces tumor cell apoptosis and down‐regulate the expression of programmed cell death ligand 1 to alleviate immunosuppressive tumor microenvironment. The mild photothermal heating can not only induce tumor‐associated antigen release, but also trigger sustainable expression of cytokine interleukin‐2. Notably, a synergistic antitumor effect is achieved between the process of p53 transfection and NIR‐II light‐activated genetic engineering of bacteria. This work proposes a facile strategy for the construction of hybrid system to achieve cascade‐augmented cancer immunotherapy.
Recent Advances in the A‐Site Cation Engineering of Lead Halide Perovskites
Authors: Ma Yunxiu , Wang Yu , Fang Yueyue , Jiang Yu , Dai Zhigao , Miao Jinshui
Published: August 2024

Lead halide perovskite (LHP) have gained considerable research attention for their numerous photoelectric applications attributed to their ease of processability and distinctive photoelectric properties. A‐site cation engineering provides an effective solution to optimize the bandgap further, enhance stability, and improve the photoelectric properties of LHP materials. In this review, an in‐depth examination of the progress achieved in the field of A‐site cation engineering on the structure, properties, synthesis methods, and photoelectric applications of LHP is presented. It is discussed how A‐site cations can change the crystal structure and improve the crystal quality, and how the A‐site cation regulates the bandgap, enhances stability, and promotes effective charge transport. Further, synthesis strategy is presented to regulate the A‐site cation. Subsequently, the applications of A‐site cation‐regulated LHP materials in solar cells, light‐emitting diodes, photodetectors, and lasers are introduced. Finally, challenges that must be overcome to further improve the properties and stability of LHP materials via A‐site cation engineering are highlighted.
Two New Mononuclear Mn(II) and Cu(II) Mixed‐Ligand Complexes Incorporating 2,6‐Di(1H‐pyrazol‐1‐yl)pyridine and 2‐Hydroxy Naphthaldehyde‐Derived Schiff Base: Structural, Theoretical, and Phenoxazinone Synthase Mimicking Activity
Authors: Abdou Aly
Published: August 2024

The current investigation involved the synthesis and detailed characterization of novel mixed‐ligand complexes of Mn(II) (MnDPPNPH) and Cu(II) (CuDPPNPH). These complexes incorporate 2,6‐di(1H‐pyrazol‐1‐yl)pyridine (DPP) and a Schiff base derived from 2‐hydroxy naphthaldehyde (NPH). The synthesized complexes revealed a stoichiometric ratio of 1:1:1 (metal:DPP:NPH), indicative of an octahedral coordination geometry around the Mn(II) and Cu(II) centers, as represented by the chemical formula [M (DPP)(NPH)(Cl)]. To elucidate their structural and electronic properties, theoretical calculations were performed. These calculations facilitated the optimization of the geometrical structures and provided insights into the molecular orbital characteristics of the complexes. The MnDPPNPH and CuDPPNPH complexes demonstrated potential phenoxazinone synthase mimicking activity by catalyzing aerial coupling of o‐aminophenol (OAPh) to form phenoxazine‐2‐one (phenox). The mimicking activity of these complexes was quantitatively assessed using Michaelis–Menten enzymatic kinetics. Various enzyme kinetics plots were employed to determine several kinetic parameters, including the specificity constant and turnover number (kcat), which are crucial for understanding the efficiency of the catalytic cycles. Remarkably, the synthesized MnDPPNPH and CuDPPNPH complexes exhibited significantly higher turnover numbers (kcat) compared to previously reported complexes. This finding suggests that these new complexes possess superior catalytic activity, highlighting their potential as effective catalysts for reactions mimicking the function of phenoxazinone synthase.
Catalytic Activity of Fe/Mn Porphyrins Grafted on Graphitic Carbon Nitride in the Heterogeneous Oxidation of Olefins
Authors: Rayati Saeed , Bathaee Hamideh , Badiei Alireza
Published: August 2024

Biomimetic heterogeneous catalysts were prepared by immobilization of meso‐tetrakis(4‐carboxyphenyl)porphyrinatomanganese(III) acetate (MnTCPP) and meso‐tetrakis(4‐carboxyphenyl)porphyrinatoiron(III) chloride (FeTCPP) on graphitic carbon nitride (g‐C3N4) nanosheets. The anchored catalysts were characterized by various techniques such as scanning electron microscopy, thermogravimetric analysis, powder X‐ray diffraction, ultraviolet visible, photoluminescence, flame atomic absorption, and Fourier transform infrared spectroscopy. The thermogravimetric analysis demonstrated that the prepared catalysts were thermally stable up to almost 350°C, exhibiting high thermal stability. In the following, the catalytic efficiency of the prepared nanocatalyst was also investigated for the oxidation of various olefins with hydrogen peroxide (as a green oxidant) and the effect of various parameters which may affect the catalytic efficiency was optimized. The maximum conversion (100% for α‐methylstyrene and 97% for cyclooctene) was obtained in the presence of MnTCPP@C3N4. The Mn porphyrin nanocatalyst shows higher catalytic efficiency compared to the Fe porphyrin.
Macroscopic preparation of polylactic acid/graphene composite fiber film with efficient antibacterial and thermal properties
Authors: Huang Tingshan , Wang Jiangfeng , Cui Keyang , You Haining , Peng Linghao , Yan Kun , Yang Chenguang , Zhao Qinghua , Wang Dong
Published: August 2024

Photothermal antibacterial composite membranes have a broad range of clinical applications such as wound dressing, drug delivery, and physiotherapy. However, existing photothermal antimicrobial films have limitations related to biosafety, stability, and degradability. Herein, we develop an environmentally‐friendly composite membrane with antibacterial properties, photothermal conversion capability, and facile processing. The composite membrane film is comprised of polylactic acid (PLA) with graphene (G) and is synthesized via melt co‐blending and hot pressing. We verify that graphene is uniformly dispersed in the PLA phase, and an antibacterial rate of 99.7% can be achieved by a PLA/G composite membrane with only 3.0 wt.% graphene added. Moreover, the obtained films exhibit efficient photothermal conversion, reaching thermal treatment temperatures (40–60°C) within 10 s and maintaining temperature stability for extended periods. Additionally, the composite fiber film exhibited a tensile strength of 3.5 cN/dtex and good hydrophobicity (>90° contact angle). The combination of antibacterial properties, efficient photothermal conversion, noninfiltration, high strength, hydrophobicity, and mechanical stability, along with the inherent degradability of PLA and the scalability of the synthesis process for mass production, offer broad application prospects for PLA‐based composite materials.
A surrogate fuel emulating the physical and chemical properties of aviation biofuels
Authors: Ding Qingmiao , Xiong Changhong , Cui Yanyu , Zhao Fang , Li Hailong
Published: August 2024

The development of aviation biofuels is a key strategy for reducing carbon emissions in the aviation industry. This study aimed to establish a surrogate model for aviation biofuels using a hybrid approach that combined explicit equations with an artificial neural network (ANN). The low heating value was calculated using an explicit equation, whereas the ANN predicted changes in density, viscosity, surface tension with temperature, and the distillation curve of the surrogate model. An optimization algorithm was then employed to identify suitable substitutes, which consisted of 11.44% n‐decane, 43.43% n‐dodecane, 43.11% n‐tetradecane, and 2.02% methylcyclohexane. The maximum error between the physical properties of the surrogate components and the measured biofuels did not exceed 7%. The ignition delay time of the substitute components matched that of real aviation biofuels at an equivalence ratio of 1.0 and a pressure of 10 bar.
Synthesis of mesoporous niobium phosphosilicate with high catalytic activity in the conversion of glucose to 5‐hydroxymethylfurfural in water solvent
Authors: Shen Wanling , Zhu Haihang , Cheng Xiaoman , Li Xin
Published: August 2024

Mesoporous niobium‐based solid acid catalysts were successfully synthesized using the soft template method with sodium lignosulfonate (SLS) as the template. In most studies the template is calcined to form mesopores after hydrothermal synthesis; however, in this study SLS was retained to produce niobium‐carbon composite catalysts. The catalysts obtained were characterized by X‐ray diffraction, nitrogen adsorption–desorption, Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis, and static contact angle measurements. The catalytic activity of the solids was also investigated in the conversion of glucose to 5‐hydroxymethylfurfural (HMF) using pure water as the solvent. Under optimal conditions, niobium‐carbon composite catalyst achieved a glucose conversion yield of 65.1% and an HMF yield of 42.1%. The enhanced catalytic activity was attributed to the timely extraction of the HMF by the carbonized SLS.
Antimicrobial Activity of ZnS and ZnO‐TOP Nanoparticles Againts Pathogenic Bacteria
Authors: Bouasla Nabila , Abderrahmane Sihem , Obeizi Zahra , Sarah Messast , Saoudi Adel
Published: August 2024

This study aims to synthesize ZnS nanoparticles (NPs) and investigate their biocidal effects, along with those of ZnO‐Trioctylphosphine (ZnO‐TOP) NPs, on various pathogenic microbes. The NPs were synthesized via the polyol method using the forced hydrolysis of zinc acetate. They were characterized by XRD and TEM. The average sizes of ZnS and ZnO‐TOP are 3.63 nm and 16.28 nm, respectively. The antimicrobial activities were assessed using agar‐well diffusion, minimum inhibitory concentration (MIC), and biofilm inhibition. The results showed that ZnS and ZnO‐TOP NPs have potent antimicrobial activity against all tested pathogen microbes. A zone of maximum inhibition (ZMI) of 20±0.54 and 22±0.26 was observed in the case of ZnS for Acinetobacter baumannii and Candida albicans, respectively. For ZnO‐TOP, a ZMI of 20±0.15 and 20±0.19 is obtained for Pseudomonas. aeruginosa ATCC 27853 and A. baumannii, respectively. Percentages of biofilm inhibition at 128 μg/ml were notably high for Enterococcus faecalis (96.83 % with ZnO‐TOP and 91.17 % with ZnS) and Staphylococcus aureus (87.27 % with ZnO‐TOP and 76.37 % with ZnS). The results suggest that ZnS and ZnO‐TOP nanoparticles have promising potential as effective antimicrobial agents, especially against biofilm‐forming pathogens, indicating their potential for future use in treating microbial infections.
Multidimensional structural racism and estimated cancer risk from traffic‐related air pollution
Authors: White Emily B. , Ekenga Christine C.
Published: August 2024

Background

Traffic‐related air pollutants have been associated with a variety of adverse human health impacts, including cancers. In the United States, numerous studies have documented racial inequities in neighborhood exposures to traffic‐related air pollution. Emerging evidence suggests that structural racism may influence neighborhood exposures to air pollutants. However, existing research has largely focused on residential racial segregation, one indicator of structural racism. This study developed a multidimensional measure of structural racism to examine the relationship between structural racism and estimated cancer risk from air pollutants in Georgia.

Methods

Carcinogenic air toxics data were obtained from the US Environmental Protection Agency’s 2019 Air Toxics Screening Assessment and sociodemographic data from the American Community Survey. Guided by stakeholder input, county‐level data on residential segregation, education, employment, incarceration, economic status, political participation, and homeownership were used to create a multidimensional county‐level structural racism index. Relative risks (RRs) were estimated for associations between structural racism and elevated (top 10% in Georgia) estimated cancer risk from air toxics.

Results

Multilevel analyses revealed a significant association between multidimensional structural racism and exposure to carcinogenic traffic‐related air pollutants. Neighborhoods in the highest quartile of structural racism exhibited an elevated cancer risk from traffic‐related air pollutants (RR, 7.84; 95% CI, 5.11–12.05) compared to neighborhoods with lower levels of structural racism.

Conclusions

Multidimensional structural racism was associated with estimated cancer risk from traffic‐related air pollution in Georgia. Findings can inform future studies and policy interventions that address racial inequalities in exposure to traffic‐related air pollution.
Junction temperature monitoring of silicon carbide MOSFET based on turn‐off voltage spike
Authors: Liu Xinbo , Liu Bo , He Shuiyuan , Diao Lijian , Diao Lijun
Published: August 2024

Because of the advantages of high switching speed, silicon carbide (SiC) devices are widely used in high‐power power electronic equipment. Real‐time monitoring of junction temperature is very important for the safe operation of equipment. There have been many studies on traditional junction temperature monitoring methods based on Si IGBT, but the dynamic characteristics of SiC MOSFETs are changed due to their different physical structure and parasitic parameters, which make the traditional methods no longer applicable. In this paper, the junction temperature can be extracted from the switching process of SiC MOSFET by using the turn‐off voltage spike as the index of thermosensitive electrical parameter (TSEP). In addition, the effect of working voltage, current, and different materials on turn‐off voltage spike is also studied. The simulation platform of Ansys/Simplorer and the experimental test platforms are built, and the theory of junction temperature detection based on turn‐off voltage spike is verified. The simulation and experimental results show that turn‐off voltage spike is a feasible TSEP, which can be used to extract junction temperature of SiC MOSFET with good linearity and instantaneity.
Bidirectional Relations Among Maternal Positive Emotion, Infant Positive Emotionality, and Infant Physiological Regulation Across the First 18 Months of Life
Authors: Shin Eunkyung , Lytle Marisa N. , Zhou Anna M. , LoBue Vanessa , Buss Kristin A. , Pérez‐Edgar Koraly
Published: August 2024

Respiratory sinus arrhythmia (RSA), a marker of self‐regulation, has been linked to developmental outcomes in young children. Although positive emotions may have the potential to facilitate physiological self‐regulation, and enhanced self‐regulation could underlie the development of positive emotions in early childhood, the relation between positive emotions and physiological self‐regulation in infancy has been relatively overlooked. The current study examined the bidirectional associations among maternal positive emotion, infant positive emotionality, and infant resting RSA across the first 18 months of life. We used data from the Longitudinal Attention and Temperament Study (LanTs; N = 309 in the current analysis) to test the within‐ and between‐person relations of study variables over time using a random‐intercepts cross‐lagged panel model. We found that infants with higher overall levels of positive emotionality also displayed greater resting RSA, and their mothers exhibited higher levels of positive emotion. However, there were negative cross‐lagged associations within‐person; higher than average infant positive emotionality predicted lower levels of infant resting RSA at the subsequent timepoint during early infancy, whereas higher than average infant RSA subsequently predicted decreased levels of infant positive emotionality later in infancy. Results highlight the importance of considering transactional relations between positive emotion and physiological self‐regulation in infancy.
A new technique for ureteral resection to prevent urine dissemination and cancer seeding
Authors: Hoshina Hayato , Sugihara Toru , Kurokawa Masayuki , Endo Kaori , Takaoka Ei‐ichiro , Ando Satoshi , Kume Haruki , Fujimura Tetsuya
Published: August 2024

Introduction

We describe a case in which robot‐assisted radical ureterectomy was performed for residual ureteral recurrence in a postoperative patient with renal pelvis cancer.

Case presentation

A 75‐year‐old woman underwent laparoscopic radical nephroureterectomy for left renal pelvic cancer at another hospital. During follow‐up, a papillary tumor was found in the bladder on cystoscopy, and a continuous tumor was found in the residual ureter on computed tomography. Robot‐assisted radical ureterectomy was performed in combination with transurethral resection of bladder tumors. To avoid urine spillage, bladder cuff excision was performed using a mechanical suture device while monitoring the interior of the bladder.

Conclusion

We developed a new technique for remnant ureteral resection using cystoscopy and a vascular stapler to prevent urine dissemination and cancer seeding.
A new species of Verbascum (Scrophulariaceae) from Iraq
Authors: Al-Musawi A. H. E. , Al-Bermani A. K.
Published: August 2024

During the taxonomic studies of the genus Verbascum, the comparison of all Iraqi herbarium material and field studies a new species, Verbascum aqranse, has been discovered. The new described species is native in the northern mountains of Iraq near Aqra.
Cytology of the tribe Dalbergieae (Leguminosae) from Nigeria
Authors: Husaini S. W. H. , Gill L. S.
Published: August 2024

Chromosome counts of 7 species in 3 genera of the tribe Dalbergieae have been made from Nigerian material. Chromosome numbers for Dalbergia lactea (n = 10), D. saxatilis (n = 10), Machaerium lunatus (n = 9) and Pterocarpus mildbraedii (n = 10) are reported here for the first time. Distribution maps of the species are provided.
Studies on Bupleurum L. in India I. Secretory Structures in the leaves
Authors: Chakrabarty Chaitali , Mukherjee P. K.
Published: August 2024

Secretory structures in the form of schizogenous canals and/or oil sacs are found to occur in thirteen of the sixteen taxa of Bupleurum L. investigated from India. Their absence was found in xeric ones. Canals are always associated with the vascular traces but this may or may not be true for sacs, which are predominantly scattered in the mesophyll tissue. Interestingly, canals differing in structure may occur with exclusion of saces, but not vice‐versa.
Über Orchis maxima C. Koch und ihre Hybride mit Orchis punctulata Stev. ex Lindl.
Authors: Kümpel Horst
Published: August 2024

Nach Untersuchungen des Autors ist Orchis maxima C. Koch morphologisch und chorologisch deuüich gegen O. purpurea Huds. abgegrenzt. O. maxima C. Koch wird beschrieben und mit O. purpurea Huds. verglichen. Kurze Anmerkungen über O. punctulata Stev. ex Lindl. und Beschreibung einer neuen Hybride O. × suckowii Kümpel aus der Umgegend von Sotschi (UdSSR). Abbildungen nach lebenden Pflanzen sind beigefügt.
Primulaceae — its evolution and assessment in status as jugded through cytotaxonomy
Authors: Sarkar A. K.
Published: August 2024

Cytological analysis on different members of Primulaceae, collected both from the Eastern and Western Himalayas, has been carried out in detail. The members embrace four genera namely Primula, Androsace, Lysimachia and Anagallis.

The species of Primula collected from the Himalayas fall under different sections proposed by different authors. Most of the sections of Primula are characterised by varying chromosome series which are quite related to each other. Evidences SO far obtained suggest that sections of Primula represent a natural assemblage. The number of species occurring in the Eastern Himalayas is found to be more than that of the Western Himalayas. In general the Himalayan representatives are mostly characterised by diploids The two numbers n = 9 and 11 are very frequent in this genus studied.

Meiosis has been found to be regular in most of the species, the karyotype data 100 have revealed some uniform features in the basic structures.

The present investigation has further revealed that in this Eastern Himalayan sector, the cytological forms are mostly represented by diploids, ansuploids and polyploids, the majority being low diploid forms. In view of extensive distribution of Primula in the Himalayas with luxuriant growth and varieties of genotypes — it appears that this Eastern Himalayan sector might have been the centre of origin of several species Primula.

Within Androsace, the general morphology of the karyotype as brought out here shows symmetry in their long chromosomes and the taxa must be regarded as primitive as compared to the members of Primula. Androsace possibly represents a step in evolution which Primula must have passed during its evolutionary development.

Lysimachia and Anagallis too have been studied during the present project The karyotype of Lysimachia shows feature common to the other genera Primula.

It may be concluded that in the evolution of the family Primulaceae, aneuploidy, polyploidy and cryptic structural alterations are the principal factors.
Nature of ergastic substances in some West African Compositae
Authors: Omoigui I. D. , Gill L. S.
Published: August 2024

Seeds of 46 species of Compositae were examined for fats & oils, starch and protein. All the examined species except 5 are herbs. Fats & oils were found to be present in all the investigated taxa and protein bodies were present in 7 species (Eleutheranthera ruderalis, Emilia coccinca, E. praetermissa, E. sonchifolia, Gynura miniata, Tithonia diversifolia and T. rotundifolia). Starch grains were found to be absent in all the investigated species.
Beiträge zum xerothermen Vegetationskomplex Böhmens III. Die Sandvegetation in Böhmen
Authors: Toman Miloslav
Published: August 2024

Dieser Teil der Arbeit beschreibt die charakteristische Krautartige Sandvegetation Böhmens und ordnet sie einerseits in die Klasse Sedo‐Scleranthetea, andererseits in den Verband Koelerio‐Phleion phlcoidis ein. Sie bringt die erste Dokumentation des Koelerio‐Phleion phleoidis in Böhmen.

Der Verfasser schlägt vor, den Verband Koelerio‐Phleion phleoidis in die Ordnung Festucetalia valesiacae zu überführen sowie die Vereinigung der Verbände Corynephorion canescentis und Koelerion glaucae als Koelerion glaucae. Es wird die Verbreitung bedeutender sandliebender Arten in Böhmen sowie ihre Reduktion auf etlichen Fundorten beschrieben. Außerdem werden die restlichen Xerothermrasen‐Gesellschaftendes Elbniederung‐Doksy‐Bezirks behandelt.
Strategic deactivation of mRNA COVID‐19 vaccines: New applications for siRNA therapy and RIBOTACs
Authors: Hulscher Nicolas , McCullough Peter A. , Marotta Diane E.
Published: August 2024

The rapid development and authorization of messenger ribonucleic acid (mRNA) vaccines by Pfizer‐BioNTech (BNT162b2) and Moderna (mRNA‐1273) in 2020 marked a significant milestone in human mRNA product application, overcoming previous obstacles such as mRNA instability and immunogenicity. This paper reviews the strategic modifications incorporated into these vaccines to enhance mRNA stability and translation efficiency, such as the inclusion of nucleoside modifications and optimized mRNA design elements including the 5′ cap and poly(A) tail. We highlight emerging concerns regarding the wide systemic biodistribution of these mRNA vaccines leading to prolonged inflammatory responses and other safety concerns. The regulatory framework guiding the biodistribution studies is pivotal in assessing the safety profiles of new mRNA formulations in use today. The stability of mRNA vaccines, their pervasive distribution, and the longevity of the encapsulated mRNA along with unlimited production of the damaging and potentially lethal spike (S) protein call for strategies to mitigate potential adverse effects. Here, we explore the potential of small interfering RNA (siRNA) and ribonuclease targeting chimeras (RIBOTACs) as promising solutions to target, inactivate, and degrade residual and persistent vaccine mRNA, thereby potentially preventing uncontrolled S protein production and reducing toxicity. The targeted nature of siRNA and RIBOTACs allows for precise intervention, offering a path to prevent and mitigate adverse events of mRNA‐based therapies. This review calls for further research into siRNA and RIBOTAC applications as antidotes and detoxication products for mRNA vaccine technology.
Charting the evolutionary conceptual pathway of analytic network process research: A main path analysis
Authors: Vílchez‐Román Carlos , Florek‐Paszkowska Anna , Mu Enrique
Published: August 2024

This study delves into the flow and structure of knowledge prevalent in Analytic Network Process (ANP) literature. It traces the evolutionary pathway of ANP research, spotlighting seminal works and unfolding the development of topics over time. Analysing 4583 ANP literature records from 1986 to 2022, this research utilizes two pivotal data sources: Web of Science (WoS) and Dimensions. This main path analysis (MPA) approach is coupled with techniques such as citation analysis, social network analysis, and centrality measures to identify most influential papers, as well as using a search path algorithm (SPC) to provide higher weights to papers that serve as bridges connecting different research paths rather than simply counting all citations equally. Key works emerged as focal points in both datasets, including notable contributions from Lee, Kheybari and Büyüközkan, with the Dimensions dataset uniquely highlighting Saaty as the initial conceptual knowledge source of the ANP. The centrality measures unearthed persistent bridge roles undertaken by key contributors such as Saaty and Sarkis over different time periods. Furthermore, a detailed topic analysis discerned eight distinctive thematic clusters among the two data sources: analytical network process, network process, fuzzy analytic, evaluation laboratory, supply chain, quality function, hierarchy process, and information systems. These clusters emerged, providing a comprehensive map of ANP topics and their evolution. The study offers a comprehensive framework for scholars to navigate the expansive domain of ANP research. Identifying pivotal works and emergent themes provides direction for future research endeavours. It allows practitioners to gain invaluable insights into the foundational and transformative works in the ANP realm, enhancing their understanding and application of the methodology. This paper proposes of a dual methodological strategy: First, by using traditional academic data sources (WoS) along with a more encompassing Dimensions database; and second, by using a SPC algorithm to weight MPA papers based on their connecting role among different research paths. At the discipline level, this study carves out a novel vantage point in understanding the ANP research landscape. It offers an integrated portrayal of the field's conceptual evolution, identifying specific cluster topics as an indispensable resource for scholars, practitioners, and students.
Failure mechanism of fully grouted rock bolts subjected to pullout test: Insights from coupled FDM‐DEM simulation
Authors: Zhao Hongyan , Duan Kang , Zheng Yang , Zhang Qiangyong , Zhang Longyun , Jiang Rihua , Zhang Jinyuan
Published: August 2024

Fully grouted rock bolts are widely used in mining, tunneling, and pit support, and thus the study of their anchorage performance is beneficial for optimizing the anchorage system design. In this study, an FDM‐DEM coupled numerical model is established to simulate the whole process of rock bolt pullout test and to investigate the failure mechanism of fully grouted rock bolts. The accuracy of the model is verified by comparison with existing laboratory test results. Virtual experiments are conducted on different models by eliminating the anchor plate, changing the layered rock strata condition, and adding bolts. The results show that the presence of an anchor plate will reduce tensile stress to restrain the rupture of surrounding rock and thus improve the strengthening effect. Due to the different bond strength and tensile strength of the soft and hard rock mediums, the layer sequence of the rock strata affects the maximum pullout force. The upper‐soft and lower‐hard composite rock strata (S‐HCR) exhibits single‐cone damage while the upper‐hard and lower‐soft composite rock strata (H‐SCR) exhibits double‐cone damage. The superposition effect of the anchor group on the stresses and displacements is the reason leading to the reduction of the maximum load‐bearing capacity of the rock bolts.
Corrections of Electron–Phonon Coupling for Second‐Order Structural Phase Transitions
Authors: Graml Mario , Hingerl Kurt
Published: August 2024

Structural phase transitions are accompanied by a movement of one nucleus (or a few) in the crystallographic unit cell. If the nucleus movement is continuous, a second‐order phase transition without latent heat results, whereas an abrupt nucleus displacement indicates a first‐order phase transition with accompanying latent heat. Herein, a Hamiltonian including electron–phonon coupling (EPC) as proposed by Kristoffel and Konsel is taken. Contrary to their treatment, both the kinetic energy of the nucleus and its position are treated. The interaction of the many‐electron system with the single nucleus is taken into account by the Born–Oppenheimer approximation and perturbative expressions for the free energies are derived. The nuclei corrections due to the entangled electrons are found to be minor, but highlight the importance of the symmetry breaking at low temperature. Furthermore the free energy for a canonical ensemble is computed, whereas Kristoffel and Konsel use a grand canonical ensemble, which allows to derive more stringent bounds on the free energy. For the zero‐order nucleus correction, the shift of the phase transition temperature by evaluating the free energy is deduced.
The impact of economic crisis, COVID‐19, and the Beirut Blast on colorectal cancer patients in Lebanon: A trend to operate more late‐stage complex cases
Authors: Osseis Michael , Habib Farid Abi , Al Rachid Maria , El Hadi Christopher , Kazan Daniel , Mouawad Christian , Chakhtoura Ghassan , Noun Roger
Published: August 2024

Background

The convergence of the economic crisis, COVID‐19 pandemic, and Beirut Blast has precipitated unprecedented challenges for the healthcare system in Lebanon, particularly for cancer patients. Amidst these crises, our study evaluates its contribution to a concerning trend of operating on more late‐stage and complex colorectal cancer (CRC) cases.

Methods

We included 155 patients operated for CRC between 2017 and 2023. Patients age; sex; operation type (emergency or elective); tumor size, grade, and location; tumour, node, metastasis stage; lymphatic, vascular and perineural invasions; American Society of Anesthesiologists (ASA) score, presentation and previous history, and complications were examined.

Results

Surgical outcomes remained relatively consistent before and after the crisis. However, there was a notable increase, with patients being 3.59 times more likely to undergo resection of adjacent organs in metastatic disease post‐crisis. Patient characteristics also exhibited notable shifts, with a 9.60‐fold increase in the likelihood of having an ASA score of at least 2 after the crisis. Additionally, there was a 5.36‐fold decrease in the odds of patients undergoing a colonoscopy before their diagnostic one post‐crisis. Preoperative carcinoembryonic antigen levels were significantly elevated post‐crisis compared to pre‐crisis levels. Pathological findings revealed increased odds of perineural, vascular, and lymphatic invasion post‐crisis. Additionally, there was a notable increase in the likelihood of hepatic synchronous metastases post‐crisis. Furthermore, a trend to operate on complicated diseases was noted with an increased number of colostomies.

Conclusion

The economic crisis in Lebanon has profoundly affected early intervention and comprehensive treatment for CRC patients, resulting in a concerning rise in late‐stage cases requiring surgical intervention.
Äußere Übersetzungsgeschichte I: Kontexte zweiter Ordnung
Authors: Mueller Nicole Marion
Published: August 2024

Das dritte Kapitel thematisiert die äußere Übersetzungsgeschichte von Tonio Kröger in Japan anhand abstrakterer Einflusskontexte zweiter Ordnung, die die Übersetzungsaktivitäten eher mittelbar prägen. Den Betrachtungsschwerpunkt bildet eine umfassende Darstellung zum kyōyōshugi-Bildungsideal und seinen Auswirkungen auf die Rezeption, wobei erst Kerncharakteristiken von kyōyōshugi vorgestellt und dann zu Thomas Mann und zur Erzählung Tonio Kröger in Beziehung gesetzt werden. Anschließend werden die historische Entwicklung und die Spezifik des japanischen Übersetzungsdenkens skizziert und der historische Verlauf der japanischen Thomas Mann-Rezeption im Abgleich mit der internationalen Rezeption chronologisch nachvollzogen.
Innere Übersetzungsgeschichte: Tonio Kröger zwischen Konsens und Abgrenzung
Authors: Mueller Nicole Marion
Published: August 2024

Das fünfte Kapitel erschließt durch Implementierung des in Kapitel 2 bereits vorgestellten Analyseverfahrens erstmalig die innere Übersetzungsgeschichte der Erzählung Tonio Kröger in Japan, indem die Ähnlichkeits- und Einflussbeziehungen zwischen den unterschiedlichen Übersetzungsvarianten mithilfe eines digitalen Themenmodells quantifiziert werden. Dabei werden die vier Schritte des Analyseverfahrens samt den jeweiligen Ergebnissen in Teilkapiteln vorgestellt, die von der quantitativ untersuchten Skalierungsebene der Gesamttexte über Topics, Topic-Paare und Absatzdokumente bis hin zur qualitativen Analyse ausgewählter Übersetzungstokens führen.
Innere und äußere Übersetzungsgeschichte im Dialog
Authors: Mueller Nicole Marion
Published: August 2024

Im sechsten Kapitel werden die Ergebnisse der relationalen Analyse von Einfluss- und Ähnlichkeitsbeziehungen zwischen den Tonio Kröger-Übersetzungstexten mit den zuvor skizzierten historischen Phasen der japanischen Thomas Mann-Rezeption abgeglichen. Anschließend werden die Erkenntnisse zur äußeren und zur inneren Übersetzungsgeschichte zu Profilen der Texte und der Übersetzenden zusammengeführt.
Energy identity for the incompressible Cahn–Hilliard/Navier–Stokes system with non–degenerate mobility
Authors: Georgiadis Stefanos
Published: August 2024

We consider the Cahn–Hilliard/Navier–Stokes system with non–degenerate mobility in the space–periodic case, describing the flow of two viscous immiscible and incompressible Newtonian fluids with matched densities. We identify sufficient conditions on the velocity field for weak solutions to satisfy an energy identity, improving previous results on the literature.
Characterisation of the Decoring Behaviour for Furan Resin Bonded Sands Using DEM Simulation
Authors: Berbić Mirnes
Published: August 2024

Sand cores and moulds form the inner and outer structures of casting parts with tolerances of up to a few tenths of a millimetre. These must fulfil two complementary characteristics. During casting, they must withstand the high thermal and mechanical loads and subsequently disintegrate without leaving any residue. The production of these mostly organically bonded cores and moulds is done with conventional manufacturing processes, such as core shooting, or what is becoming increasingly more important for foundries, using 3D printing. In order to better understand this complex disintegration behaviour of these different core types and thus minimise the enormous energy input for their removal, a suitable simulation model based on discrete element methods (DEM) is considered as a tool to describe and further analyse the prevailing complex interactions in more detail. This contribution discusses the characterisation of furan resin bonded sand cores/parts, presenting various test apparatuses designed for this purpose, and outlines the foundational setup and definition of bonded-particle models (BPM) to be used as breakable structures in respective DEM simulations.
Therapieprogramm zur Steigerung von Organisationsfähigkeit, Konzentration und Impulskontrolle bei Kindern mit ADHS (THOKI-ADHS)
Authors: Braun Sonja , Döpfner Manfred
Published: August 2024

Organisationsfähigkeit, Konzentration und Impulskontrolle sind wesentliche Voraussetzungen für die Entwicklung von Kindern und Jugendlichen. Schwierigkeiten in diesen Bereichen lassen sich regelmäßig bei Kindern mit Aufmerksamkeitsdefizit-/Hyperaktivitätsstörungen (ADHS) feststellen. THOKI-ADHS ist das erste deutschsprachige Therapieprogramm, mit dem Defizite in den organisatorischen Fähigkeiten gezielt behandelt werden können.
Das Therapiemanual gibt zunächst einen Überblick über die Symptomatik, Pathogenese und den Verlauf von ADHS und referiert den aktuellen Stand zu wirksamen Behandlungsansätzen. Ausführlich wird anschließend das therapeutische Vorgehen in den 13 Modulen beschrieben. THOKI-ADHS ist für Kinder im Alter von sechs bis zwölf Jahren konzipiert und vor allem für den Einsatz im Einzelsetting gedacht. Ziel von THOKI-ADHS ist es, die konkreten Schwierigkeiten von Kindern hinsichtlich Organisationsfähigkeit, Konzentration und Impulskontrolle im Familienalltag, in der Schule und im Freizeitbereich zu identifizieren, anhand von simulierten Situationen im Rahmen der Therapiesitzungen zu modifizieren und danach den Transfer in den Alltag zu unterstützen. Neben den kindzentrierten Interventionen kommt auch der Integration von Eltern und anderen Bezugspersonen in die Behandlung eine wichtige Rolle zu. Zudem wird im Manual erläutert, wie eine mögliche Durchführung im Gruppensetting aufgebaut sein kann und wie ergänzend digitale Technologien zum Einsatz kommen können. Zahlreiche Arbeitsmaterialien für die Arbeit mit den Kindern sowie zwei Fragebögen zur Erfassung von Funktionseinschränkungen in relevanten Alltagssituationen können nach erfolgter Registrierung von der Hogrefe Website heruntergeladen werden.
Seasonal Variations and Controls on Triple Oxygen and Hydrogen Isotopes in Precipitation—A Case Study From Monitoring in Southwest China
Authors: Liang Qi‐Sheng , Sha Li‐Juan , Li Jun‐Yun , Zhang Jian , Wang Xue‐Jie , Zhou Shi‐Lun , Lin Fang‐Yuan , Xue Yan‐Xia , Duan Rong , He Ya‐Ting , Li Hua‐Yan , Wang Chen‐Yi , Liu Bao , Hou Yong‐Kang , Chen Chao‐Jun , Cheng Hai , Li Ting‐Yong
Published: August 2024

Precipitation δ18O has offered valuable insights into the evolution of the Asian monsoon. Recent researches focusing on precipitation Δ′17O has enhanced our understanding by offering new perspectives beyond those of δ18O, revealing insights into vapor sources and continental recycling. Nevertheless, there remains a lack of interannual triple oxygen isotope data, particularly in the Asian monsoon region. In this study, we analyzed the triple oxygen isotopes and hydrogen isotopes in monthly precipitation samples collected from Chongqing in Southwest China between 2019 and 2022 A.D. Seasonal variations in δD, δ18O, δ17O, and d‐excess values were observed, with lower values during the rainy season and higher values during the dry season, highlighting the impact of changes in moisture sources and local meteorological conditions on seasonal shifts in δD, δ18O, and δ17O. While, mean Δ′17O values were higher in rainy season and lower in dry season. Notably, during rainy season, there is a negative correlation between monthly Δ′17O values and the RH of the vapor source area, as well as a positive correlation with d‐excess. Recalculated Δ′17O values based on RH of oceanic moisture source, are higher than the measured values for this period, indicating the contribution of terrigenous moisture to precipitation in SW China. Precipitation Δ′17O values provide a more precise reflection of changes in moisture source, continental recycling, and evapotranspiration processes that drive water cycling compared Integrating modeling works in future will facilitate the use of precipitation Δ′17O values to quantify the impact of different moisture source on precipitation.
Projection of Low Cloud Variation Through Robust Meteorological Linkage and Its Comparison With CMIP6 Models at the SACOL Site
Authors: Li Yize , Ge Jinming , Du Jiajing , Peng Nan , Su Jing , Hu Xiaoyu , Zhang Chi , Mu Qingyu , Li Qinghao
Published: August 2024

Low clouds significantly influence Earth's energy budget by reflecting solar radiation. Consequently, inadequate representation of these clouds in models introduces the largest uncertainty in predicting future climate change. This study investigates low cloud cover (LCC) variation using 6 years (2014–2019) of high‐precision ground‐based Ka‐band Zenith Radar (KAZR) observations at the Semi‐Arid Climate and Environment Observatory of Lanzhou University (SACOL). We analyze the relationship between observed low cloud properties and four large‐scale meteorological factors: 700 hPa relative humidity, estimated inversion strength, low‐level wind shear, and 700 hPa vertical velocity. These factors are identified as key parameters influencing low cloud evolution over this semi‐arid region. We utilize principal component analysis to integrate these parameters into a single meteorological predictor (PC1) and establish a robust linkage between meteorological conditions and low cloud properties. By comparing LCC fluctuations derived from the meteorological factors with those directly simulated by models over the same period, we assess the projected LCC trends under various carbon emission scenarios. Contrary to the declining LCC projected by CMIP6 models outcomes, the LCC form PC1 shows a rising tendency by 2100 under global warming. This discrepancy implies that CMIP6 models may exaggerate the extent of future warming at the SACOL site. Our approach can be applied to a broader global distribution of low clouds to examine the differences between low cloud variations constrained by meteorological fields and those from direct model simulations. This will enhance our understanding of low cloud feedback on future climate change.
Insights into aging mechanisms from comparative genomics in orange and silver roughies
Authors: Carrero Dido , Pascual-Torner Maria , Álvarez-Puente Diana , Quesada Víctor , García-Gómez Claudia , López-Otín Carlos
Published: August 2024

The demersal fish orange roughy (Hoplostethus atlanticus) can live for up to 250 years, twenty times more than its congener silver roughy (Hoplostethus mediterraneus). Studies of Hoplostethus have focused mainly on its ecology and conservation due to its vulnerability to commercial fishing. In this work, we present the de novo genomes of orange and silver roughies and explore the genomic mechanisms that could contribute to such differential longevities. Using comparative genomics on a list of more than 400 genes, we identified gene candidates with differential residue changes in Hoplostethus that are related to genomic instability, disabled macroautophagy and intercellular communication. We hypothesized that these mechanisms could have been selected as adaptations to the deep environment and, as an epiphenomenon of these mechanisms, may have contributed to an extension of the lifespan of H. atlanticus.
Research on the Impact of Social Media on Brand Loyalty
Authors: Cai Shanglin
Published: August 2024

This study aims to explore the impact of social media on brand loyalty. By analyzing brand interaction, consumer engagement, and the breadth and depth of information dissemination on social media, this study reveals its impact mechanism on brand cognition, brand relationship, and brand attitude. The study uses web crawler technology to collect interactive data from brand official accounts, and uses descriptive statistical analysis, Pearson correlation analysis, multiple regression analysis, and structural equation model (SEM) for data analysis. The results show that brand interaction significantly improves consumers’ brand cognition, consumer engagement plays an important role in brand relationships, and the breadth and depth of information dissemination help to enhance brand attitudes. These factors work together to significantly improve brand loyalty. This research is fundamental because it proves the fact that brand cognition, brand relationship, and brand attitude have a direct effect on brand loyalty, and brand relationship is, of all factors, the most positive factor which influences brand loyalty. This research not only enriched theoretical studies on brand loyalty but also verified the brand marketing strategy on social media with empirical evidence. Moreover, companies increase their brand loyalty by using a better interactivity platform with the consumers, the width and depth of information passing increase, which results in a rise in the level of user engagement by consumers, and the company can increase its competitive advantage in the market.
Innovation of Media Business Models in the Digital Economy Era
Authors: Cai Shanglin
Published: August 2024

This research delves into the evolution of media business models in the digital economy period, with a specific emphasis on examining the key aspects of technology-centered and customer-focused. The research defined how essential components like value proposition, customer segments, and revenue streams are uniquely implemented in the media sector's business model. It has considered real contributions in big data, artificial intelligence, and blockchain that augment efficiency with respect to content creation, user experience, and equality with concern to revenue sharing in the media industry. The current piece of research at the same time emphasizes analyzing users' behavior and gauging users' involvement to enhance their level of engagement and satisfaction ratio. After this, it plunges deep into two details of new critical media platforms in TikTok and Facebook, describing successful business models detailing user growth trends, sources of revenue for firms, user distribution, and other dataset details. The findings recommend how, in this era, where the digital economy is growing tremendously, media companies should keep working persistently to innovate business models through an amalgamation of technology-driven with customer-oriented methods to make it sterling in such a stiff market. This study offers theoretical backing and practical guidance for the development of new media business models, with significant practical implications.