bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical effectiveness of robotic versus laparoscopic and open surgery: an overview of systematic reviews
Authors: Lai Tzu-Jung , Roxburgh Campbell , Boyd Kathleen Anne , Bouttell Janet
Published: September 2024

Objective

To undertake a review of systematic reviews on the clinical outcomes of robotic-assisted surgery across a mix of intracavity procedures, using evidence mapping to inform the decision makers on the best utilisation of robotic-assisted surgery.

Eligibility criteria

We included systematic reviews with randomised controlled trials and non-randomised controlled trials describing any clinical outcomes.

Data sources

Ovid Medline, Embase and Cochrane Library from 2017 to 2023.

Data extraction and synthesis

We first presented the number of systematic reviews distributed in different specialties. We then mapped the body of evidence across selected procedures and synthesised major findings of clinical outcomes. We used a measurement tool to assess systematic reviews to evaluate the quality of systematic reviews. The overlap of primary studies was managed by the corrected covered area method.

Results

Our search identified 165 systematic reviews published addressing clinical evidence of robotic-assisted surgery. We found that for all outcomes except operative time, the evidence was largely positive or neutral for robotic-assisted surgery versus both open and laparoscopic alternatives. Evidence was more positive versus open. The evidence for the operative time was mostly negative. We found that most systematic reviews were of low quality due to a failure to deal with the inherent bias in observational evidence.

Conclusion

Robotic surgery has a strong clinical effectiveness evidence base to support the expanded use of robotic-assisted surgery in six common intracavity procedures, which may provide an opportunity to increase the proportion of minimally invasive surgeries. Given the high incremental cost of robotic-assisted surgery and longer operative time, future economic studies are required to determine the optimal use of robotic-assisted surgery capacity.
Does multifactorial inspiratory muscle training improve postural stability and quality of life of patients with diabetes in Pakistan? A randomised controlled trial
Authors: Sheraz Suman , Malik Arshad Nawaz , Ferraro Francesco Vincenzo , Siddiqi Furqan Ahmed
Published: September 2024

Objective

To determine the effects of multifactorial inspiratory muscle training (IMT) combined with Otago Exercise Programme (OEP) on balance and quality of life (QoL) in patients with diabetes.

Methods

Pretest–post-test randomised controlled trial.

Setting

Rehabilitation Department of Pakistan Railway General Hospital.

Participants

70 patients with diabetes were randomly assigned to experimental or placebo groups, out of which 59 patients completed the intervention.

Intervention

Patients in the experimental group performed OEP+IMT (at 50% of baseline maximum inspiratory pressure (MIP)) whereas the placebo group performed OEP+sham IMT (at 15% of MIP). Both groups exercised for 12 consecutive weeks.

Outcome measures

Outcome measures included nine variables: the Berg Balance Scale (BBS), the Biodex Postural Stability System (including postural stability test (Overall Stability Index, Anterior–Posterior Index and Mediolateral Index), fall risk test (FRT), Limits of Stability (LOS) test (time to complete test and direction control), Clinical Test of Sensory Interaction and Balance (CTSIB)) and the Audit of Diabetes Dependent Quality of Life questionnaire.

Results

Out of 59 patients who completed treatment, 37.1% were men and 62.9% were women with a mean age of 58.37±5.91 years. Results show significant interaction effects on BBS scores with the mean score improving from 41.87±2.61 to 49.16±2.50 in IMT versus sham IMT group with scores improving from 41.58±2.51 to 45.74±2.30. The IMT group significantly improved in dynamic balance tested through BBS (p=0.003), anticipatory balance through LOS test (p=0.003), reactive balance tested through FRT (p=0.04), direction control (p=0.03) and sensory integration through CTSIB test (p=0.04) when compared with the sham IMT group. While no significant changes (p>0.05) between groups were observed in QoL and static balance; significant changes (p<0.05) within group were observed in both groups in QoL and static balance.

Conclusion

Additional research is necessary to understand the association between inspiratory muscle strength and balance, however, we demonstrated that a multifactorial IMT intervention should be used with patients with diabetes to improve balance, postural control and reduce fall risks.

Trial registration number

ClinicalTrials.gov, NCT#04947163.
Temporal trends in mortality and causes of death in patients with incident atrial fibrillation: a nationwide register study from 2010 to 2018
Authors: Kouki Elis , Salmela Birgitta , Aro Aapo , Halminen Olli , Teppo Konsta , Haukka Jari , Putaala Jukka , Linna Mika , Mustonen Pirjo , Hartikainen Juha , Airaksinen Juhani K E , Lehto Mika
Published: September 2024

Objectives

Atrial fibrillation (AF) is associated with increased mortality. Previous studies have reported conflicting results in temporal trends of mortality after AF diagnosis. We aim to address this disparity by investigating the 1-year mortality and causes of death in Finnish patients diagnosed with AF between 2010 and 2017.

Design

The Finnish AntiCoagulation in Atrial Fibrillation (FinACAF) study is a nationwide retrospective register-based cohort study.

Setting

The FinACAF study has gathered information on all Finnish AF patients between 2004 and 2018, with information from all national healthcare registers and data from all levels of care (primary, secondary and tertiary care).

Participants

We included patients with an incident AF diagnosis (International Classification of Diseases, 10th Revision code I48) between 2010 and 2017. To ensure a cohort of only incident AF, we excluded patients who used any oral anticoagulant during the year before cohort entry as well as patients with a recorded use of warfarin between 2004 and 2006. Patients under 20 years of age were excluded, and patients with permanent migration abroad before 1 January 2019 were excluded, N=157 658.

Primary outcome measures

1-year all-cause, cardiovascular (CV) and cause-specific mortality following AF diagnosis.

Results

The study cohort consisted of 157 658 incident AF cases (50.1% male, mean age 72.9 years). Both all-cause and CV mortality declined from cohort entry years 2010–2017 (from 12.9% to 10.6%, mortality rate ratio (MRR) 0.77; 95% CI 0.73 to 0.82 in cohort entry year 2017 with 2010 as reference; and from 7.4% to 5.2%, MRR 0.68; 95% CI 0.63 to 0.74, respectively). Overall mortality and CV mortality were lower in women than in men throughout the study period (MRR 0.66; 95% CI 0.63 to 0.69 and MRR 0.53; 95% CI 0.50 to 0.56, respectively). Deaths attributable to ischaemic heart disease decreased during the study period (from 30.7% to 21.6%, MRR 0.51; 95% CI 0.49 to 0.62 in 2017 vs 2010), whereas dementia and Alzheimer’s disease increased as a cause of death over time (6.2% to 9.9%, MRR 1.19; 95% CI 0.96 to 1.48 in 2017 vs 2010). The CHA2DS2-VASc score associated strongly with 1-year survival (p<0.0001).

Conclusions

Our study reiterates that mortality after diagnosis of AF has decreased. The CHA2DS2-VASc score highlights the need to treat comorbidities as it strongly associates with patient 1-year survival after initial AF diagnosis.
Characteristics and primary care experiences of people who self-report as autistic: a probability sample survey of adults registered with primary care services in England
Authors: Tromans Samuel Joseph , Teece Lucy , Saunders Catherine , McManus Sally , Brugha Traolach
Published: September 2024

Objectives

Little is known about adults who self-report as autistic. This study aimed to profile the demographic characteristics, long-term health conditions and primary care experiences of adults who self-report as autistic (including those with and without a formal diagnosis).

Design/setting

A nationally representative cross-sectional survey of adults registered with National Health Service (NHS) General Practitioner (GP) surgeries in England.

Participants

623 157 survey respondents aged 16 and over, including 4481 who self-report as autistic.

Outcomes

Weighted descriptive statistics, with 95% CIs. Logistic regression modelling adjusted for age, gender, ethnicity and area-level deprivation compared those who self-report as autistic with the rest of the population.

Results

A total of 4481 of the 623 157 survey participants included in the analysis self-reported autism, yielding a weighted proportion estimate of 1.41% (95% CI 1.35% to 1.46%). Adults self-reporting as autistic were more likely to be younger, male or non-binary, to identify as a gender different from their sex at birth, have a non-heterosexual sexual identity, be of white or mixed or multiple ethnic groups, non-religious, without caring responsibilities, unemployed, live in more deprived areas and not smoke. All chronic conditions covered were more prevalent among adults self-reporting as autistic, including learning disability, mental health conditions, neurological conditions, dementia, blindness or partial sight and deafness or hearing loss. Adults self-reporting as autistic were also less likely to report a positive experience of making an appointment (adjusted OR (aOR) 0.90, 95% CI 0.82 to 0.98) and navigating GP practice websites (aOR 0.78, 95% CI 0.70 to 0.87) and more likely to report seeking advice from a friend or family member prior to making an appointment (aOR 1.25, 95% CI 1.14 to 1.38) and having a preferred GP (aOR 2.25, 95% CI 2.06 to 2.46). They were less likely to report that their needs were met (aOR 0.73, 95% CI 0.65 to 0.83).

Conclusions

Adults self-reporting as autistic have a distinctive sociodemographic profile and heightened rates of long-term conditions. They report challenges in both accessing primary care and having their needs met when they do. These findings should inform future care initiatives designed to meet the needs of this group.
Physiotherapy rehabilitation experiences of people with shoulder dislocation in ARTISAN study: a qualitative study
Authors: Naghdi Seyran , Ellard David R , Kearney Rebecca
Published: September 2024

Background

Acute Rehabilitation following Traumatic anterior shoulder dISlocAtioN (ARTISAN) was a large trial comparing the clinical and cost-effectiveness of two rehabilitation interventions in adults with a first-time traumatic shoulder dislocation. Participants were allocated to receive either a single session of advice (ARTISAN) or a single session of advice and a programme of physiotherapy (ARTISAN plus). Trial results illustrated that additional physiotherapy after an initial session was not superior in improving functional outcomes for participants.

Objectives

In this study, we aim to explore the experiences of a purposive sample of participants from both the ARTISAN and ARTISAN plus groups regarding their rehabilitation journey.

Design

This is a semistructured interview-based study.

Setting

The study was conducted in the United Kingdom.

Participants

Thirty-one participants of ARTISAN trial: 16 participants from ARTISAN group and 15 from ARTISAN plus group.

Outcome measures and analysis

The study follows the consolidated criteria for reporting qualitative research. The framework analysis was used to synthesise the participants’ experiences. The interviews were coded through NVivo 12.6.1.

Results

Three dominant and interrelated topics emerged from the interview data: (1) feelings about their shoulder rehabilitation outcome, (2) judgement of ARTISAN rehabilitation materials, (3) assessment of shoulder rehabilitation service provision.

Conclusion

Both forms of intervention have some merit for some individuals. Thus, it may be appropriate to look at the patients’ preference for offering treatment to them. Recognising and facilitating this will be of benefit to both the patients and healthcare as a whole.
Implementation of decarbonisation actions in general practice: a systematic review and narrative synthesis protocol
Authors: Karaba Florence , Nunes Ana Raquel , Geddes Olivia , Atherton Helen , Dahlmann Frederik , Eccles Abi , Gregg Michael , Spencer Rachel , Twohig Helen , Dale Jeremy
Published: September 2024

Introduction

There is growing recognition of the importance of primary care in addressing climate change. The World Organisation of Family Doctors has urged general practitioners worldwide to commit to tackling climate change and to serve as agents of systemic and individual change. Though an increasing number of resources have become available to support the decarbonisation of primary care, there remains a lack of evidence about how primary care teams are using them, their reach across practices, their level of adoption and maintenance, their cost impact and their effect on carbon emissions. This systematic review aims to understand how primary care, with a focus on general practice or equivalent settings within the context of primary care, is implementing decarbonisation actions to reduce carbon emissions arising from its operations, assess efficacy of the actions and generate recommendations on how to assist and accelerate their implementation and effectiveness.

Methods and analysis

The literature search will be conducted on Medline, Embase, Web of Science, CINAHL and ProQuest, from 2007 to 29 March 2024. Article screening will be based on specified inclusion and exclusion criteria. Narrative synthesis will be used to analyse and integrate findings to offer new insights into key mechanisms that support decarbonisation in general practice and help refine an initial programme theory. The reporting of the systematic review will follow the Preferred Reporting Items for Systematic Review and Meta-Analysis framework.

Ethics and dissemination

This review did not involve the collection or analysis of any data that was not included in previously published research in the public domain. The results will be disseminated through peer-reviewed publication and conference presentations.

PROSPERO registration number

CRD42023470889.
Community-based dementia risk management and prevention program for Aboriginal Australians (DAMPAA): a randomised controlled trial study protocol
Authors: Lalovic Alex , Dowden Glennette , Markey Lesley , Bynder Michael , Yappo Lynette , Cox Kay L , Mateo-Arriero Irene , Flicker Leon , Bessarab Dawn , Thompson Sandra , Kickett Carmel , Woods Deborah , Pestell Carmela F , Edgill Paula , Hill Keith , Etherton-Beer Christopher , LoGiudice Dina , Almeida Osvaldo P , Lin Ivan , Milte Rachel , Ratcliffe Julie , Hyde Zoë , Smith Kate
Published: September 2024

Introduction

Aboriginal and Torres Strait Islander peoples are the First Peoples of Australia. Up to 45% of dementia in these populations is due to potentially modifiable risk factors. The Dementia Prevention and Risk Management Program for Aboriginal Australians (DAMPAA) is an Aboriginal Health Practitioner led programme that aims to reduce cognitive decline and functional impairment in older Aboriginal people.

Methods

Design: DAMPAA is a multisite, randomised controlled trial aiming to deliver and evaluate a culturally appropriate risk factor management programme. Population: Community-dwelling Aboriginal people aged 45–90 years. Intervention: Participants will be randomly assigned to either usual care (control) or to a group programme comprising exercise and health education yarning sessions and pharmacist-delivered medication reviews delivered over a 12-month period. Primary outcome: Cognitive function (Kimberley Indigenous Cognitive Assessment (KICA)-Cog score), daily function (KICA-Activities of Daily Living (ADL) score) and quality of life (Good Spirit, Good Life and EQ-5D-5L scores). Secondary outcomes: Process evaluation interviews, cardiovascular risk factors, falls and death. Process evaluation will be conducted with qualitative methods. Quantitative outcomes will be analysed with generalised linear mixed models.

Ethics and dissemination

The study was approved by the Western Australian Aboriginal Health Ethics Committee and the University of Western Australia Human Research Ethics Committee. Study results will be published in peer-reviewed journals and presented at scientific meetings. We will also develop and disseminate a comprehensive DAMPAA toolkit for health services. The study’s findings will guide future prevention strategies and outline a comprehensive process evaluation that may be useful in other Aboriginal health research to contextualise findings.
Recurrent ocular toxoplasmosis is associated with interferon-gamma deficiency possibly due to genetic origin
Authors: Hautala Nina Maria , Joensuu Maija , Paakkola Teija , Glumoff Virpi , Kettunen Kaisa , Saarela Janna , Siiskonen Mira , Chen Zhi , Pylkäs Katri , Hautala Timo
Published: September 2024

Objective

Ocular toxoplasmosis (OT) can cause posterior uveitis; causes of recurrent OT are not well understood. We explored clinical, immunological and genetic properties associated with recurrent OT.

Methods and analysis

A recurrent OT patient population (n=9) was identified. Clinical history, ophthalmological findings and immunological properties were assessed. B and T cell immunophenotyping including interferon-gamma (IFN-γ) responses were analysed. An analysis of 592 immunodeficiency genes was performed.

Results

The patients experienced 2–7 OT episodes (average 3.7). The first episode occurred at an average of 23.8 (SD 10.1) years of age. All patients had anterior uveitis, vitritis and various fundus lesions of OT. The patients had lymphocyte maturation abnormalities; the proportion of naive CD4+CD45RA+CCR7+T cells was high in 5/9 cases, and the percentage of CD4+CD45RA−CCR7−T effector memory cells was reduced in 7/9 cases. An increased percentage of CD19+CD38lowCD21lowactivated B cells was observed in 5/9 cases. IFN-γ response was reduced in CD4+(8.45±4.17 vs 21.27±11.0, p=0.025) and CD8+(39.0±9.9 vs 18.1±18.1, p=0.017) T cells. Genetic analysis revealed several potentially harmful variants in immunologically activeERCC3, MANBA, IRF4, HAVCR2, CARMIL2, CD247, MPO, C2andCD40genes.

Conclusion

Our recurrent OT cases had deviations in lymphocyte maturation and IFN-γ responses possibly caused by genetic reasons. However, limitations of our study include failure to identify uniform genetic mechanisms. In addition, we cannot rule out the possibility that the immunological abnormalities can be triggered by chronic toxoplasmosis. Despite the limitations, our findings contribute to the understanding of ocular immunity and development of recurrent OT.
Intestinal fatty acid binding protein is associated with infarct size and cardiac function in acute heart failure following myocardial infarction
Authors: Nendl Andraž , Andersen Geir Øystein , Seljeflot Ingebjørg , Trøseid Marius , Awoyemi Ayodeji
Published: September 2024

Background

In acute heart failure (HF), reduced cardiac output, vasoconstriction and congestion may damage the intestinal mucosa and disrupt its barrier function. This could facilitate the leakage of bacterial products into circulation and contribute to inflammation and adverse cardiac remodelling. We aimed to investigate gut leakage markers and their associations with inflammation, infarct size and cardiac function.

Methods

We examined 61 ST-elevation myocardial infarction (STEMI) patients who developed acute HF within 48 hours of successful percutaneous coronary intervention (PCI). Serial blood samples were taken to measure lipopolysaccharide (LPS), LPS-binding protein (LBP), soluble cluster of differentiation 14 (sCD14) and intestinal fatty acid binding protein (I-FABP). Cumulative areas under the curve (AUCs) from baseline to day 5 were calculated. Serial echocardiography was performed to assess left ventricular ejection fraction (LVEF), global longitudinal strain (GLS) and wall motion score index (WMSI). Single-photon emission CT (SPECT) was performed at 6 weeks to determine infarct size and LVEF.

Results

I-FABPAUCcorrelated positively with infarct size (rs=0.45, p=0.002), GLS (rs=0.32, p=0.035) and WMSI (rs=0.45, p=0.002) and negatively with LVEF measured by SPECT (rs=−0.40, p=0.007) and echocardiography (rs=−0.33, p=0.021) at 6 weeks. LPSAUC, LBPAUCand sCD14AUCdid not correlate to any cardiac function marker or infarct size. Patients, who at 6 weeks had above median GLS and WMSI, and below-median LVEF measured by SPECT, were more likely to have above median I-FABPAUCduring admission (adjusted OR (aOR) 5.22, 95% CI 1.21 to 22.44; aOR 5.05, 95% CI 1.25 to 20.43; aOR 5.67, 95% CI 1.42 to 22.59, respectively). The same was observed for patients in the lowest quartile of LVEF measured by echocardiography (aOR 9.99, 95% CI 1.79 to 55.83) and three upper quartiles of infarct size (aOR 20.34, 95% CI 1.56 to 264.65).

Conclusions

In primary PCI-treated STEMI patients with acute HF, I-FABP, a marker of intestinal epithelial damage, was associated with larger infarct size and worse cardiac function after 6 weeks.
Agriculture-informed Neural Networks for Predicting Nitrous Oxide Emissions
Authors: Lin Ci , Li FuTong , Killeen Patrick , Yeap Tet , Kiringa Iluju
Published: September 2024

Agriculture and Agri-Food Canada, in its unwavering commitment to sustainable agriculture, has launched a program to reduce nitrous oxide (N
2
O) emissions from fertilizer utilization in farming practices. This initiative is a response to the pressing environmental and climate challenges we face. To achieve our goal, we must delve into the mechanism of N
2
O emission by measuring and predicting the flux of N
2
O. This study proposes a novel architecture for neural network models, namely the agriculture-informed neural network (AINN) model, consisting of recurrent neural networks and a process-based ecosystem model, the Dynamic Land Ecosystem Model (DLEM), to predict N
2
O emissions from farming. During the 2021 and 2022 growing seasons, field data on the flux of N
2
O, soil temperature, and soil moisture were collected. However, the amount of nitrate in the soil was missing since collecting accurate data on nitrate quantities from the soil was challenging. Therefore, assumptions about the nitrate quantity in the soil were made when training and testing AINN with the data collected from the 2021 and 2022 growing seasons. In 2024, from January to April, an indoor experiment under controlled conditions was successfully executed to collect data on nitrate quantity in the soil. This experiment demonstrated that nitrate quantity is an essential factor for predicting the emission of N
2
O.

To demonstrate the versatility of the AINN across various neural networks, we conduct a comprehensive comparison with four state-of-the-art models: multilayer perceptron, convolutional neural network, long short-term memory, and Transformer. Our experiment and simulation results unequivocally demonstrate that the performance of AINN is superior to single neural network models. The DLEM component of the AINN acts as a regularizer, facilitating the training process of the AINN. This mathematical formulation transforms the problem of N
2
O emission into a constrained optimization issue, minimizing the explicit objective function and satisfying the constraints of the parameters fed into the DLEM in the AINN. The empirical results show that by incorporating information from the agricultural field, the AINN significantly reduces the generalization error compared to the corresponding neural network, underscoring its potential to revolutionize the field of neural network modeling.
An Expectation-Maximization framework for Personalized Itinerary Recommendation with POI Categories and Must-see POIs
Authors: Panagiotakis Costas , Daskalaki Evangelia , Papadakis Harris , Fragopoulou Paraskevi
Published: September 2024

In this article, we introduce a novel deterministic method based on Expectation Maximization (EM) to solve the rather complex problem of designing a tourist trip or Personalized Itinerary Recommendation (PIR). PIR objective is to recommend a personalized tour consisting of successive Points of Interest (POIs), which maximizes user satisfaction and respects user time-frame constraints. On top of that, the POIs are divided into categories, in order for travelers to be able to set limits on the maximum (and minimum) number of POIs that belong to one category and are included in the itinerary. In the proposed framework, emphasis is given on the POIs sequence selection, which exploits the customized POI recommendations offered by a recommender system. Additionally, the proposed methodology with POIs categories is able to solve the TourMustSee problem, so that the tour includes a set of POIs that must be visited. The proposed system has been successfully incorporated into a mobile app, offering a complete tourist trip design. The high performance, resilience, and computational efficiency of the proposed framework are demonstrated by experimental findings and comparisons to existing approaches on numerous synthetic and real datasets.
Mathematical Modeling and Experimental Investigation of the Dynamic Response for an Annular Circular Plate Made of Glass/Polyester Composite Under Different Boundary Conditions
Authors: Hashim Riyadh Makki , Sarhan Samaher Mohammed , Al-Shamma Fathi , Mohammed M. N. , Al-Zubaidi Salah , Abdullah Oday I.
Published: September 2024

Fiber‐reinforced elastic laminated composites are extensively used in several domains owing to their high specific stiffness and strength and low specific density. Several studies were performed to ascertain the factors that affect the composite plates’ dynamic properties. This study aims to derive a mathematical model for the dynamic response of the processed composite material in the form of an annular circular shape made of polyester/E‐glass composite. The mathematical model was developed based on modified classical annular circular plate theory under dynamic loading, and all its formulas were solved using MATLAB 2023. The mathematical model was also verified with real experimental work involving the vibration test of the fabricated composite plate. The composite plate was processed by reinforcing the polyester matrix with E‐glass fibers with a 50% volume fraction each by using the handy lay‐up method. After fabrication, the composite plate was tested with a universal vibration tester, where the plate was impacted and released to free vibration, and the deflection was measured experimentally to compare it with the theoretical value calculated from the derived model. The plate was tested under two boundary conditions, namely, simply and built‐in supported. The findings show good agreement between theoretical and experimental plate deflections at different angles, particularly at built‐in supported boundary conditions. Also, a higher natural frequency was recorded at this condition compared to others, and this may be ascribed to the higher shear stresses involved due to large moments at the ends along with supporting. Meanwhile, the real experimental spectrum of the built‐in condition was higher than others, as the sig view curve revealed.
Research on Neural Network Prediction Model of Whole Process Risk Management Based on Building Information Model
Authors: Huang Shihong , Liang Chengye , Liu Jiao
Published: September 2024

With the rapid development of China’s construction industry and the acceleration of urbanization, large‐scale public building projects are becoming increasingly important in urban development, and the risk management problems of them should be pay more attention to. Based on the integration of back propagation (BP) neural network and building information model (BIM) technology, this paper carries out the research on risk management process of the whole life cycle of large public buildings and identifies the risk factors of large public buildings from the application dimension and the management dimension. The risk management evaluation index system is constructed and identified, and assessment, early warning, prevention, and control of risk management are applied and analyzed throughout the process. The international large public sports center project is used as a case study to establish a BIM model, while the BP neural network risk management model is used for prediction and calculation. The results of this study show that, first, the maximum deviation rate of the output indicators of the BP neural network risk model is 3.57% in the design period (B2) and the minimum deviation rate is 0.00% in the commissioning period (B4), which verifies the reliability of the training results of the model. Second, the best effect of risk management in the whole life cycle of the building is in the investment period (B1) and the highest risk is in the construction period (B3). Last, this paper constructs a new risk management framework to realise the risk management of the whole cycle of construction projects from design to operation, which helps to improve the management level and risk response ability of construction projects and ensure the smooth and sustainable development of the whole life cycle of construction.
Calculation Method for Bearing Capacity of Bottom‐Supported Anti‐Pull Piles in Layered Foundation
Authors: Zeng Jianming , Wang Zhengzhen , Chen Xuwei , Lian Na , Li Feng
Published: September 2024

In recent years, with the rapid development of cities, the utilization rate of underground space has gradually increased, and anti‐pull piles have also been widely used in practical engineering. In this paper, the failure surface form of the anti‐pull pile was assumed, the soil parameters of each soil layer in the layered foundation and the Poisson effect generated by the anti‐pull pile under the action of the uplift force was considered, and the calculation formula for the bearing capacity of the anti‐pull long pile in the layered foundation was obtained, which was verified by on‐site test data. Finally, the parameter range of the calculation method was analyzed. The results show that when the aspect ratio of the anti‐pull pile is large, and the elastic modulus of the anti‐pull pile is small, the Poisson effect of the anti‐pull pile is obvious, and the increment of pile side friction caused by the Poisson effect is also large. When the value range of parameter N is 50 ≤ N ≤ 100, the calculation results are more reasonable. The average error of the lower limit N = 50 is 11.7%, and the average error of the upper limit N = 100 is 5.3%.
A Joint Analysis of Metabolomics, Network Pharmacology, and Molecular Docking Reveals the Efficacy Patterns in Various Medicinal Segments of Angelica sinensis (Oliv.) Diels Root
Authors: Guo Xiaopeng , Li Xuee , Zhang Shengli , Zhu Shuhua , Guo Rong , Gao Yue , Wang Yonggang , Liu Xiaofeng , Liu Yan , Shi Hao
Published: September 2024

Angelica sinensis (Oliv.) Diels root (ASR) is a medicinal and edible traditional Chinese herb medicine. Understanding the varying efficacies in different ASR segments and their associated pharmacological mechanisms at the metabolome level has been a largely unexplored research area. This study integrates metabolomics, network pharmacology, and molecular docking to investigate the characteristics and mechanisms underlying hemostasis, blood enrichment, and blood circulation promotion in distinct ASR medicinal segments. The distinguishable metabolic spectra were visually presented for the head (ASRH), body (ASRB), and tail (ASRT) in ASR, highlighting the dominant metabolites in each. Furthermore, a network linking components, targeted proteins, signaling pathways, and diseases was constructed. The combined analysis of metabolomics and network pharmacology confirms that ASRT primarily enhances blood circulation, whereas ASRH and ASRB lean toward hemostasis and blood enrichment. The dominant ingredients of ASRT mainly influence signaling pathways of calcium, PI3K‐Akt, and arachidonic acid metabolism by modulating targeted proteins like EGFR, SRC, AKT1, and HSP90AA1, thus enhancing hemodynamics. In contrast, the dominant ingredients of ASRH and ASRB regulate PI3K‐Akt, IL‐17, and JAK‐STAT signaling pathways via proteins, such as CTNNB1, AKT1, SRC, and EP300, playing a role in hemostasis and blood enrichment. These results were subsequently validated by molecular docking. This study innovatively combines metabolomics, network pharmacology, and molecular docking to preliminarily reveal the mechanisms governing hemostasis, blood enrichment, and blood circulation improvement regulated through multiple components, targeted proteins, and pathways in different ASR segments. These findings offer valuable insights for future investigations into the efficacies of distinct ASR segments.
Strategies to Mitigate Greenhouse Gas (GHG) Emissions from the Solid Waste Management Sector: A Case Study of Vavuniya, Sri Lanka
Authors: Kayanan Sobana , Basnayake B. F. A. , Ariyawansha R. T. K.
Published: September 2024

The waste sector is a substantial source of GHG emissions worldwide. Open dumping and internal combustion (IC) waste collection vehicles are significant sources of GHG emissions in Vavuniya. This research aims to estimate GHG emissions and recommend strategies to reduce emissions from the solid waste management sector. The IPCC methodology, considering Tier 1 estimation values based on default activity data, was used to estimate CH4 emissions from solid waste disposal sites. GHG emissions from collection vehicles were calculated based on IPCC mobile combustion recommendations. Three recommended strategies were considered based on demand, economic, and environmental feasibility and are expected to commence in 2025. According to current practices, open dumping generated 29.217 Gg of CO2 equivalent up to 2023, projected to rise by 37.8% by 2040. There will be a 57% decrease in open dumping‐related GHG emissions by 2040 if composting is made mandatory for biodegradable waste, even though it produces emissions. Solar panels will be used to charge electric vehicles that will replace IC ones to cut emissions and fuel expenditures by 2025. The carbon sink reforestation program at the district level would need to begin in 2025 with an area of 161 hectares to sequester cumulative GHG emissions from composting dumpsites and fuel vehicles to achieve carbon neutrality by 2040. Investments from Vavuniya Carbon Sink Bonds (VCSB) on additional solar panels will ensure financial feasibility, having an internal rate of return of 23.18%. It paves the path to reducing GHG emissions, which is highly emphasized in the Nationally Determined Contributions, National Climate Change Policy, and waste management policy of Sri Lanka.
Ultrasound of the Lacrimal Gland in Healthy Shih Tzu Dogs and with Dry Eye Disease
Authors: Neves Carla Amorim , Rodrigues da Silva Wanessa Patrícia , Ribeiro Fayad Andre , Zanon Ignácio Beatriz , Vasconcelos Lima Aline Maria , Cristina Borges Naida
Published: September 2024

Dry eye disease (DED) is a very common disease in dogs, especially that of immune‐mediated origin, with Shih Tzu dogs being some of the most affected. In this study, ultrasound changes of the orbital lacrimal gland (LG) were described in healthy Shih Tzu dogs and those diagnosed with different intensities of DED. For training purposes, a macroscopic and ultrasonographic study of the orbits of brachycephalic dog cadavers (n = 6) was conducted. Subsequently, thirty‐five eyes from 23 male and female dogs aged between two and eight years, distributed into four groups according to the Schirmer tear test (STT‐1), including a control group (CG, n = 10) (STT‐1 ≥15 mm/min), early DED group (DED1, n = 8) (STT‐1 between 14 and 11 mm/min), moderate DED group (DED2, n = 7) (STT‐1 between 10 and 6 mm/min), and severe DED group (DED3, n = 10) (STT‐1 ≤5 mm/min), were used. Ultrasound evaluation of LG showed a higher occurrence of glandular tissue heterogeneity (p = 0.755) and the presence of hyperechoic areas (p = 0.027) in dogs with DED3. The variables measuring the major axis were lower in dogs with DED3 (p = 0.002). The area and perimeter were smaller in dogs with DED3 than in CG and DED1 groups (p < 0.001) and the perimeter of the LG of dogs in the DED2 group was smaller than that of CG (p < 0.001). The LG major axis (r = 0.56), area (r = 0.66), and perimeter (r = 0.66) decreased as the STT‐1 of the different groups decreased. LG ultrasound of Shih Tzu dogs is a feasible technique that allows the evaluation of characteristics of the glandular tissue. The ultrasound could identify changes in texture, echogenicity, and size in LG of Shih Tzu dogs with immune‐mediated DED.
Supplementary Data from Oncogenic Calreticulin Induces Immune Escape by Stimulating TGFβ Expression and Regulatory T-cell Expansion in the Bone Marrow Microenvironment
Authors: Schmidt Dominik , Endres Cornelia , Hoefflin Rouven , Andrieux Geoffroy , Zwick Melissa , Karantzelis Nikolaos , Staehle Hans F. , Vinnakota Janaki Manoja , Duquesne Sandra , Mozaffari Jovein Miriam , Pfeifer Dietmar , Becker Heiko , Blazar Bruce R. , Zähringer Alexander , Duyster Justus , Brummer Tilman , Boerries Melanie , Baumeister Julian , Shoumariyeh Khalid , Li Juan , Green Anthony R. , Heidel Florian H. , Tirosh Itay , Pahl Heike L. , Leimkühler Nils , Köhler Natalie , de Toledo Marcelo A.S. , Koschmieder Steffen , Zeiser Robert
Published: September 2024

Supplementary data
Supplemental material from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis
Authors: Bermejo-Rodriguez Camino , Araos Henríquez Joaquín , Caligiuri Giuseppina , Pinto Teles Sara , Park Youngkyu , Evans Anthony , Barrera Lawrence N. , Neesse Albrecht , Grützmann Robert , Aust Daniela , Rümmele Petra , Knösel Thomas , Narita Masako , Narita Masashi , Campbell Fiona , Öhlund Daniel , Pilarsky Christian , Dow Lukas E. , Humbert Patrick O. , Biffi Giulia , Tuveson David A. , Perez-Mancera Pedro A.
Published: September 2024

List of Supplementary Tables
Figure S9 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis
Authors: Bermejo-Rodriguez Camino , Araos Henríquez Joaquín , Caligiuri Giuseppina , Pinto Teles Sara , Park Youngkyu , Evans Anthony , Barrera Lawrence N. , Neesse Albrecht , Grützmann Robert , Aust Daniela , Rümmele Petra , Knösel Thomas , Narita Masako , Narita Masashi , Campbell Fiona , Öhlund Daniel , Pilarsky Christian , Dow Lukas E. , Humbert Patrick O. , Biffi Giulia , Tuveson David A. , Perez-Mancera Pedro A.
Published: September 2024

Supplementary Figure 9
Supplementary Data File from IDH1 Inhibition Potentiates Chemotherapy Efficacy in Pancreatic Cancer
Authors: Zarei Mehrdad , Hajihassani Omid , Hue Jonathan J. , Loftus Alexander W. , Graor Hallie J. , Nakazzi Faith , Naji Parnian , Boutros Christina S. , Uppin Vinayak , Vaziri-Gohar Ali , Shalaby Akram S. , Asara John M. , Rothermel Luke D. , Brody Jonathan R. , Winter Jordan M.
Published: September 2024

Supplementary Data File
Figure S5 from IDH1 Inhibition Potentiates Chemotherapy Efficacy in Pancreatic Cancer
Authors: Zarei Mehrdad , Hajihassani Omid , Hue Jonathan J. , Loftus Alexander W. , Graor Hallie J. , Nakazzi Faith , Naji Parnian , Boutros Christina S. , Uppin Vinayak , Vaziri-Gohar Ali , Shalaby Akram S. , Asara John M. , Rothermel Luke D. , Brody Jonathan R. , Winter Jordan M.
Published: September 2024

Figure S5
Figure S3 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis
Authors: Bermejo-Rodriguez Camino , Araos Henríquez Joaquín , Caligiuri Giuseppina , Pinto Teles Sara , Park Youngkyu , Evans Anthony , Barrera Lawrence N. , Neesse Albrecht , Grützmann Robert , Aust Daniela , Rümmele Petra , Knösel Thomas , Narita Masako , Narita Masashi , Campbell Fiona , Öhlund Daniel , Pilarsky Christian , Dow Lukas E. , Humbert Patrick O. , Biffi Giulia , Tuveson David A. , Perez-Mancera Pedro A.
Published: September 2024

Supplementary Figure 3
Figure S11 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis
Authors: Bermejo-Rodriguez Camino , Araos Henríquez Joaquín , Caligiuri Giuseppina , Pinto Teles Sara , Park Youngkyu , Evans Anthony , Barrera Lawrence N. , Neesse Albrecht , Grützmann Robert , Aust Daniela , Rümmele Petra , Knösel Thomas , Narita Masako , Narita Masashi , Campbell Fiona , Öhlund Daniel , Pilarsky Christian , Dow Lukas E. , Humbert Patrick O. , Biffi Giulia , Tuveson David A. , Perez-Mancera Pedro A.
Published: September 2024

Supplementary Figure 11
Supplementary Figures from An Atlas of Accessible Chromatin in Advanced Prostate Cancer Reveals the Epigenetic Evolution during Tumor Progression
Authors: Shrestha Raunak , Chesner Lisa N. , Zhang Meng , Zhou Stanley , Foye Adam , Lundberg Arian , Weinstein Alana S. , Sjöström Martin , Zhu Xiaolin , Moreno-Rodriguez Thaidy , Li Haolong , Alumkal Joshi J. , Aggarwal Rahul , Small Eric J. , Lupien Mathieu , Quigley David A. , Feng Felix Y.
Published: September 2024

Supplementary Figures
Supplementary Table 3 from The macrophage-associated lncRNA MALR facilitates ILF3 liquid-liquid phase separation to promote HIF1α signaling in esophageal cancer
Authors: Liu Jia , Liu Ze-Xian , Li Jia-Jun , Zeng Zhao-Lei , Wang Jin-Hong , Luo Xiao-Jing , Wong Chau-Wei , Zheng Jia-Bo , Pu Heng-Ying , Mo Hai-yu , Sheng Hui , Wu Qi-Nian , Li Hao , Wan Gang , Li Bo , Wang De-shen , Xu Rui-Hua , Ju Huai-Qiang
Published: September 2024

Supplementary Table 3
Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization
Authors: Karreman Matthia A. , Bauer Alexander T. , Solecki Gergely , Berghoff Anna S. , Mayer Chanté D. , Frey Katharina , Hebach Nils , Feinauer Manuel J. , Schieber Nicole L. , Tehranian Cedric , Mercier Luc , Singhal Mahak , Venkataramani Varun , Schubert Marc C. , Hinze Daniel , Hölzel Michael , Helfrich Iris , Schadendorf Dirk , Schneider Stefan W. , Westphal Dana , Augustin Hellmut G. , Goetz Jacky G. , Schwab Yannick , Wick Wolfgang , Winkler Frank
Published: September 2024

Supplementary Figures and Figure legends, Supplementary Video legends and supplementary materials and methods
Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization
Authors: Karreman Matthia A. , Bauer Alexander T. , Solecki Gergely , Berghoff Anna S. , Mayer Chanté D. , Frey Katharina , Hebach Nils , Feinauer Manuel J. , Schieber Nicole L. , Tehranian Cedric , Mercier Luc , Singhal Mahak , Venkataramani Varun , Schubert Marc C. , Hinze Daniel , Hölzel Michael , Helfrich Iris , Schadendorf Dirk , Schneider Stefan W. , Westphal Dana , Augustin Hellmut G. , Goetz Jacky G. , Schwab Yannick , Wick Wolfgang , Winkler Frank
Published: September 2024

Supplementary Movie 5
Supplementary Table 4 from Spatial transcriptomics depict ligand-receptor crosstalk heterogeneity at the tumor-stroma interface in long-term ovarian cancer survivors
Authors: Ferri-Borgogno Sammy , Zhu Ying , Sheng Jianting , Burks Jared K. , Gomez Javier A. , Wong Kwong Kwok , Wong Stephen T. C. , Mok Samuel C.
Published: September 2024

MIA immune enrichment group comparison
Supplementary Materials and Methods from Spatial transcriptomics depict ligand-receptor crosstalk heterogeneity at the tumor-stroma interface in long-term ovarian cancer survivors
Authors: Ferri-Borgogno Sammy , Zhu Ying , Sheng Jianting , Burks Jared K. , Gomez Javier A. , Wong Kwong Kwok , Wong Stephen T. C. , Mok Samuel C.
Published: September 2024

Supplementary Materials and Methods
Supplementary Data Legends from Nucleophosmin plays a role in repairing DNA damage and is a target for cancer treatment
Authors: Sekhar Konjeti R. , Freeman Michael L.
Published: September 2024

Legends for Supplementary Tables
Supplementary Data from Large B-cell lymphomas of immune privileged sites relapse via parallel clonal evolution from a common progenitor B-cell
Authors: Los-de Vries G. Tjitske , Stathi Phylicia , Rutkens Ryanne , Hijmering Nathalie J. , Luijks Jeroen A.C.W. , Groenen Patricia J.T.A. , de Jong Daphne , Ylstra Bauke , Roemer Margaretha G.M.
Published: September 2024

Supplementary Data
Supplementary Table from Ubiquitin ligases Siah1a/2 control alveolar macrophage functions to limit carcinogen-induced lung adenocarcinoma
Authors: Scortegagna Marzia , Du Yuanning , Bradley Linda M. , Wang Kun , Molinolo Alfredo , Ruppin Eytan , Murad Rabi , Ronai Ze'ev A.
Published: September 2024

Sup Table 4
Supplementary Fig 7 from Ubiquitin ligases Siah1a/2 control alveolar macrophage functions to limit carcinogen-induced lung adenocarcinoma
Authors: Scortegagna Marzia , Du Yuanning , Bradley Linda M. , Wang Kun , Molinolo Alfredo , Ruppin Eytan , Murad Rabi , Ronai Ze'ev A.
Published: September 2024

Sup Fig 7
Supplementary Data from ONC201 in combination with paxalisib for the treatment of H3K27-altered diffuse midline glioma
Authors: Jackson Evangeline R. , Duchatel Ryan J. , Staudt Dilana E. , Persson Mika L. , Mannan Abdul , Yadavilli Sridevi , Parackal Sarah , Game Shaye , Chong Wai Chin , Jayasekara W. Samantha Nilanthi. , Le Grand Marion , Kearney Padraic S. , Douglas Alicia M. , Findlay Izac J. , Germon Zacary P. , McEwen Holly P. , Beitaki Tyrone S. , Patabendige Adjanie , Skerrett-Byrne David A. , Nixon Brett , Smith Nathan D. , Day Bryan , Manoharan Neevika , Nagabushan Sumanth , Hansford Jordan R. , Govender Dinisha , McCowage Geoffrey B. , Firestein Ron , Howlett Meegan , Endersby Raelene , Gottardo Nicholas G. , Alvaro Frank , Waszak Sebastian M. , Larsen Martin R. , Colino-Sanguino Yolanda , Valdés-Mora Fatima , Rakotomalala Andria , Meignan Samuel , Pasquier Eddy , Andre Nicolas , Hulleman Esther , Eisenstat David D. , Vitanza Nicholas A. , Nazarian Javad , Koschmann Carl , Mueller Sabine , Cain Jason E. , Dun Matthew D.
Published: September 2024

All Supplementary Figures and their captions.
Figure S1 from Ccr2+ monocyte-derived macrophages influence trajectories of acquired therapy resistance in Braf-mutant melanoma
Authors: Kim Dahihm , An Luye , Moon Jiwon , Maymi Viviana I. , McGurk Alexander I. , Rudd Brian D. , Fowell Deborah , White Andrew C.
Published: September 2024

Tyr-CreER, LSL-BrafV600E, Ptenflox/flox genetically engineered mouse model (TBP GEMM).
Table S1 from Metformin reprograms tryptophan metabolism to stimulate CD8+ T cell function in colorectal cancer
Authors: Huang Xiaowen , Sun Tiantian , Wang Jilin , Hong Xialu , Chen Huimin , Yan Tingting , Zhou Chengbei , Sun Danfeng , Yang Chen , Yu TaChung , Su Wenyu , Du Wan , Xiong Hua
Published: September 2024

Table S1 included primers used in real-time PCR
Supplementary Table 5 from Unique transcriptional profiles underlie osteosarcomagenesis driven by different p53 mutants
Authors: Chachad Dhruv , Patel Lalit R. , Recio Carlos Vera. , Pourebrahim Rasoul , Whitley Elizabeth M. , Wang Wenyi , Su Xiaoping , Xu An , Lee Dung-Fang , Lozano Guillermina
Published: September 2024

Gene annotation performed by HOMER of p53 ChIP peaks from p53R248W osteoblasts
Supplementary File 2 from Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway
Authors: Ludwig Michael P. , Galbraith Matthew D. , Eduthan Neetha Paul. , Hill Amanda A. , Clay Michael R. , Moreno Tellez Cristiam , Wilky Breelyn A. , Elias Anthony , Espinosa Joaquín Maximiliano. , Sullivan Kelly D.
Published: September 2024

Nutlin-3-treated LPS transcriptome analyses.
Figure S7 from Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation of Transposable Element Loci
Authors: Kanholm Tomas , Rentia Uzma , Hadley Melissa , Karlow Jennifer A. , Cox Olivia L. , Diab Noor , Bendall Matthew L. , Dawson Tyson , McDonald James I. , Xie Wenbing , Crandall Keith A. , Burns Kathleen H. , Baylin Stephen B. , Easwaran Hariharan , Chiappinelli Katherine B.
Published: September 2024

Supplemental Figure 7