bluuebunny/crossref_metadata_2025 huggingface dataset:
CHARACTERISTICS OF THE CATIONIC TRPA1-CHANNALS FAMILY IN TRICHOPLAX SP. H2 (PLACOZOA)
Authors: Fadeeva M. , Sergeeva E. , Rybakova K. , Kuznetsov A.
Published: November 2022

Mechanoreceptors can transform external mechanical forces into electrochemical signals that induce cell membrane depolarization and initiate waves propagating along the cell surface. The TRPN1/NompC mechanotransduction channel is known to contain ankyrin repeats that act as a gating helix in Drosophila melanogaster [Jin et al., 2017]. In this work, we present for the first time a family of cationic TRPA1-channels in Trichoplax sp. H2 (Placozoa), which consists of 42 homologs ranging from 468 to 3240 aa in length. Three isolated clusters with different polypeptide chain lengths and various contents of ankyrin repeats were identified within the family. The spatial structure of TRPA1-channel RDD36842.1 was reconstructed, and aspirin, a possible TRP-channel blocker, was docked. The structure of the family members is analyzed, the mechanical model of channel operation is considered, and the probable function and physiology of these protein molecules and their role in the behavior of trichoplax are discussed. Variations in the number of ankyrin repeats at the N-terminus of TRP-proteins studied, and the differences detected at the C-terminus can indicate the polyfunctionality of these proteins in Placozoa. Perhaps TRP channels arose in early evolutionary stages before the appearance of multicellularity, but diversified in multicellular animals as the structural organization of those became more complex.
Simulation of The Application of an Adaptive Smart Envelope to an Existing Building in Rhinoceros Grasshopper
Authors: Al Rawi Lina Qassim , Khalid Abdul Wahhab
Published: November 2022

In recent decades, many factors have emerged in the building design field, as the technology development after the industrial revolution has left many environmental problems affecting building environments and turning them into unhealthy ones. Also, the issues of consuming natural resources required innovative and modern solutions to address, which needed the guidance and focus of researchers, engineers, and many other relevant disciplines to find the best treatments to solve them. One of the essential treatments was using advanced smart technology to solve the environmental problems of buildings, such as providing thermal comfort and reducing energy consumption.
The concept of adaptive smart envelopes is one of this manifestation of advanced technology in the field of building design characterized by interaction and adaptation to the surrounding environment through the application of many technologies which it works to improve its environmental efficiency. The research aim was to simulate the changes in the building environment, which is treated by covering the building with an adaptive smart envelope by using the Rhinoceros Grasshopper programme.
Simulação para o controle otimizado em rede sensória de nivelamento
Authors: Aleixo Leonardo Guimarães
Published: November 2022

Este trabalho desenvolve método em simulação para o controle de nivelamento em reservatórios, utilizando modelagem matemática otimizada,com análise numérica de sinais processados por microcontrolador. O estudo permite desenvolver automatização de sinais por acionamento em equipamento, utilizando código livre e material de baixo custo acessível ao estudante e pesquisador. Também são apresentados os diagramas de controle com visualização gráfica da simulação matemática, com fins em ampliar para um sistema otimizado mais complexo.A pesquisa também permite projetar uma rede operativa e acadêmica, para a automação de equipamentos computadorizados com o controle de bombeamento sistemático.
A morphometric analysis of shape, size and position of mental foramen in dry human mandibles
Authors:   Department of Anatomy, Teerthanker Mahaveer Medical College & Research Centre, TMU, Moradabad, India, Sharma Nidhi
Published: November 2022

Aim: To calculate size, shape and position of mental foramen. Materials & Methods: 50 dry human mandibles of either gender (20- females, 30- males) were included. The position of mental foramen in horizontally was calculated based on classification proposed by Bokhari. The vertical position was divided into six types using the modified Ngeow and Yuzawati criteria. Size was measured both vertically and horizontally with the help of vernier caliper and expressed as mean. Results: Most common horizontal position was II seen in both males (left- 56%, right- 50%) and females (left- 60%, right- 58%). Most common vertical position was 2 seen in males (left- 62%, right- 65%) and females (left- 55%, right- 52%). Most common shape was oval seen in both genders (males- 68% left, 62% right) and (females- 70% left, 72% right). A significant difference was observed (P<0.05). Conclusion: Variation in shape, size and position was observed both males and females, however, most common shape found to be oval and position was II horizontally and 2 vertically in both genders
Names of botanical genera dedicated to genuine persons
Authors: Iliana Alexandrova Ilieva  , Iliana Ilieva
Published: November 2022

The current review article deals with names of botanical genera derived from personal names of ingenuine people (eponyms). It is a sort of continuation of the article dealing with generic names inspired by mythology, and like it is part of the project: Linguistic structure of binomial botanical denominations. Based on Conspectus of the Bulgarian vascular flora, genera names dedicated to real people are alphabetically arranged and accompanied by a short biographical reference for the corresponding eponym. The main word-formative rules relating to the grammatical form of this type of genera names are analyzed, indicating the detected deviations from the established nomenclature norms. Several particular cases of genera names involving additional word-formative elements also are noted.
Pengaruh Proses Normalizing Terhadap Kekuatan Tarik Sambungan Las pada Logam Tidak Sejenis
Authors: Unggul Unggul Satria Jati , Prabowo Dian , Kustiawan Anjar
Published: November 2022

Pengelasan tidak sejenis atau dissimilar metals merupakan kebutuhan yang penting bagi dunia industri. Jenis pengelasan tersebut juga banyak digunakan untuk sambungan-sambungan yang mempunyai keguanaan khusus. Penelitian ini membahas mengenai penyambungan material yang tidak sejenis dengan menambahkan proses normalising, dengan tujuan untuk mendapatkan hasil sambungan pengelasan yang terbaik pada sifat materialnya. Material yang digunakan adalah baja tahan karat AISI 304 dan baja karbon A36 dilas menggunakan las Gas Metals Arc Welding (GMAW) posisi mendatar dengan pengaturan tegangan 20 volt, arus 100 Amper. dan filler yang digunakan adalah ER308 dengan variasi normalising 4000C, 5000C dan 6000C. Pengujian yang dilakukan pada penelitian ini adalah uji tarik. Setelah dilakukan 12 kali percobaan spesimen maka didapatkan hasil bahwa proses normalising pada sambungan las GMAW dengan material tidak sejenis mempunyai pengaruh yang signifikan dimana spesimen kekuatan tariknya lebih baik dibandingkan tidak mendapatkan perlakuan. Pengaruh tersebut teramati pada spesimen dengan proses normalising 6000C yang menghasilkan kekuatan tarik paling besar yaitu 500,12 Mpa dan nilai regangan tarik yaitu 15,69%. Sedangkan pada spesimen tanpa proses normalising menghasilkan kekuatan tarik sebesar 471,08 Mpa dan regangan tarik sebesar 11,99 %.
Tinjauan Overall Equipment Effectiveness (OEE) Pada Produksi Kertas Terhadap Standar JIPM
Authors: Sepfitrah  , Pranoto Siswo , Rizal Yose , Rinaldi
Published: November 2022

Penelitian ini bertujuan untuk meningkatkan efektivitas produksi memanfaatkan hasil perhitungan nilai OEE (Overall Equipment Effectiveness). OEE adalah salah satu cara untuk mencari dan  memonitor efektivitas proses kerja dari suatu perusahaan.Setiap perusahaan menginginkan tingkat efektif yang tinggi dalam proses produksi yang dilakukannya. Salah satu upaya yang dilakukan guna menganalisa efektivitas proses produksi dalam hal ini adalah proses pada Paper Machine#3 di PT. XYZ. Dengan sistem TPM (Total Productive Maintenance), yaitu melibatkan operator sebagai pemeran utama untuk melakukan perawatan mesin, penelitian ini dimulai dengan mengidentifikasi kerugian peralatan (Equipment Losses) dan mengukur pencapaian nilai OEE satu lini produksi. Dari periode penelitian yang dilakukan pada Paper Machine#3 (Desember 2016 – July 2018) didapatkan nilai Availability 81,6%, nilai Performance 87,8%, Rate of Quality 92,65% dan nilai OEE 66,85%. Nilai ini masih dibawah nilai OEE standar yaitu  84%. Rata-rata losses terbesar pada Paper Machine#3 terdapat pada Equipment Failure yaitu 44,6%, Set-up & Adjust yaitu 19.05%, Reduce Speed Loss yaitu 12,5%  dan Rewinder Broke Loss yaitu 10,6%. Untuk meningkatkan nilai OEE ke nilai standar perlu diambil tindakan seperti membina kerjasama antar lini produksi dan manajemen agar terbentuk tim kerja yang solid. Perlunya dilakukan pelatihan guna meningkatkan kemampuan tim  maintenance dalam bertindak cepat dan tepat
NILAI PENDIDIKAN DAN IDENTITAS SOSIAL CALON BRAHMANA DALAM NOVEL AROK DEDES
Authors: Suwarta Nyoman Suwarta
Published: November 2022

Tujuan penelitian menganalisis gambaran proses pembelajaran calon Brahmana dan  proses pembentukan identitas sosial calon Brahmana. Analisis menggunakan Pendekatan Psikologi Pendidikan dan Identitas Sosial. Metode kualitatif  digunakan melalui kajian literature dan interpretasi peristiwa. Instrumen penelitian menggunakan human instrument. Gambaran pendidikan dalam novel Arok Dedes sangat religius, meliputi kegiatan membaca rontal, menghafal paramasastra, berpendapat dan berpikir kritis terhadap realitas masyarakat, sangat menghormati serta bersikap sopan dan santun kepada guru, disiplin dengan kegiatan dan budaya asrama/pemondokan, taat dengan semua aturan asrama/pemondokan. faktor penentu keberhasilan siswa dalam proses pembelajaran meliputi faktor  internal dan eksternal. Proses yang mengubah seseorang menjadi anggota calon Brahmana adalah Penggolongan diri dan Perbandingan Sosial. Terdapat motivasi kuat seseorang menjadi calon brahmana.Kata kunci: pembelajaran, identitas sosial
REFLEKSI DIRI GURU BAHASA INDONESIA DALAM PEMBELAJARAN BERDIFERENSIASI DI SEKOLAH PENGGERAK
Authors: Jatmiko Henry Trias Puguh , Putra Rian Surya
Published: November 2022

Tujuan penelitian ini adalah mendeskripsikan refleksi guru bahasa Indonesia dalam mengimplementasikan pembelajaran berdiferensiasi, (b) menggambarkan perbaikan-perbaikan yang dilakukan guru bahasa Indonesia dalam implementasi pembelajaran berdiferensiasi. Penelitian ini menggunakan teknik wawancara sebagai pengumpulan datanya, teknik dokumentasi berupa gambar yang berada lingkungan kelas dan sekolah. Sumber data penelitian ini salah satu guru komite pembelajar di sekolah penggerak. Data dianalisis menggunakan teknik analisis data miles amd Hubbermen, yakni teknik analisis mengalir. Hasil penelitian ini menunjukkan bahwa refleksi guru bahasa Indonesia dalam pembelajaran berdiferensiasi yang dilakukan di sekolah penggerak melingkupi asesmen diagnosis, diferensiasi konten, diferensiasi, proses, dan diferensiasi produk. Secara lebih detail pelaksanaannya tersebut cukup banyak mengalami kendala bahkan terdapat kegiatan yang diluar dari ketentuan kurikulum merdeka. Hal tersebut diantaranya, asesmen diagnosis yang belum memenuhi ketentuan/melaui tahapan sebuah Tindakan asesmen, guru masih kebingungan dalam mengintegrasikan kesiapan belajar, gaya belajar, dan kesiapan belajar. Selain itu, hasil refleksi juga mengungkapkan bahwa guru memiliki keunggulan dalam implementasi pembelajaran berdiferensiasi. Keunggulan tersbut, yakni bahwa guru sering memvariasi dalam pembelajaran, guru menjadi idola para peserta didik, dan guru secara resmi dipilih oleh masyarakat SMA N 1 Gapura. Hal ini menjadikan murid lebih santai saat pelajaran bahasa IndonesiaKata Kunci: Refleksi guru dan pembelajaran berdiferensiasi
Tabu search heuristic for inventory routing problem with stochastic demand and time windows
Authors: Maghfiroh Meilinda Fitriani Nur , Redi Anak Agung Ngurah Perwira
Published: November 2022

This study proposes the hybridization of tabu search (TS) and variable neighbourhood descent (VND) for solving the Inventory Routing Problems with Stochastic Demand and Time Windows (IRPSDTW). Vendor Managed Inventory (VMI) is among the most used approaches for managing supply chains comprising multiple stakeholders, and implementing VMI require addressing the Inventory Routing Problem (IRP). Considering practical constraints related to demand uncertainty and time constraint, the proposed model combines multi-item replenishment schedules with unknown demand to arrange delivery paths, where the actual demand amount is only known upon arrival at a customer location with a time limit. The proposed method starts from the initial solution that considers the time windows and uses the TS method to solve the problem. As an extension, the VND is conducted to jump the solution from its local optimal. The results show that the proposed method can solve the IRPSDTW, especially for uniformly distributed customer locations.
Momordica charantia extract modulates inﬂammatory response in human lymphocytes via suppression of TNF-α
Authors: Fischer Paula , Gomes Gabriela Cristiane Mendes , Etcheverry Bibiana Frasson , Rios Nathália Vieira , Chaves Pamella Eduardha Espindola , Sotelo Emily Clori , Campos Dyene Nascimento , Zuravski Luísa , Escobar Taiane Acunha , Machado Michel Mansur
Published: November 2022

Introducción: Momordica charantia L. es ampliamente utilizada para consumo y medicina tradicional debido a sus actividades biológicas. Sin embargo, se sabe poco sobre los efectos del melón amargo en las células sanas. Por lo tanto, nuestro objetivo fue evaluar los efectos del extracto de Momordica charantia en linfocitos humanos aislados, especialmente en aspectos inflamatorios, citotóxicos, genotóxicos y mutagénicos.

Método: Para ello se preparó un extracto hidroetanólico con frutos y semillas y se procedió a la identificación y cuantificación fitoquímica. Los linfocitos humanos purificados se expusieron a 12,5, 25 y 50 µg/mL de extracto de Momordica charantia durante 24 horas y después de este período.

Resultados: Los datos mostraron que el extracto de Momordica charantia no indujo citotoxicidad, alteraciones en la frecuencia de micronúcleos, ni actividad de interleucina-6, interleucina-10 ciclooxigenasa-2 y producción de óxido nítrico; sin embargo, causó daño en el ADN y una disminución de TNF-α en las condiciones experimentales y células aplicadas.

Conclusiones: Nuestros datos proponen un proceso antiinflamatorio generado por Momordica charantia mediado por la reducción de TNF-α.
Nutrición parenteral suplementada en el final de la vida: consideraciones nutricionales y tecnológicas
Authors: Rivas Garcia Francisco , Giménez-Martinez Rafael , López-Viota Gallardo Margarita
Published: November 2022

Introducción: El final de la vida (FV) implica un periodo en el cual una determinada enfermedad u otra situación conducen a un inexorable camino hacia la muerte. La situación clínica hace muy complejo el abordaje del FV, especialmente en aquellos estadios donde la vía parenteral constituye la única forma para proporcionar el soporte nutricional.

Método: Se realizó una revisión bibliográfica narrativa basada en la búsqueda, en distintas bases de datos tales como Medline, Science Direct y Scopus, de todos los artículos publicados, hasta marzo de 2021, que muestran una serie de consideraciones nutricionales y tecnológicas de la nutrición parenteral (NP) suplementada y sus posibles beneficios en el FV.

Resultados: Se hace necesario realizar una adecuada monitorización del FV con NP para determinar la importancia de adicionar suplementos nutricionales, por sus efectos beneficiosos, tales como glutamina, arginina, zinc, cromo, citrulina, selenio, zinc o coenzima Q para atenuar las alteraciones propias del FV y evitar nuevas complicaciones. También, deben considerarse una serie de criterios tecnológicos que garanticen la estabilidad de la NP y sus nutrientes.

Conclusiones: La NP suplementada que se administra en el FV implica controlar una serie de factores que están implicados en su estabilidad. Se han observado acciones beneficiosas de NP suplementada con zinc, selenio, cromo y taurina.
Sino-European Solar Panel Dispute: China’s Successful Carrot and Stick Approach Towards Europe
Authors: Pepermans Astrid
Published: November 2022

This article considers the Sino-European solar panel conflict, which occurred between 2012 and 2014. The article takes a particular interest in how China and Europe coped with the trade dispute, which arose after several European solar companies filed a complaint in the European Commission accusing the Chinese of unfair trade practices (i.e. dumping and illegal subsidising). An analysis of the internal and external challenges that were decisive for the outcome of the trade conflict is illustrated, after which the article makes some conclusions about the concept of economic statecraft, how it is applied and on the effectiveness of European economic diplomacy in the changing Sino-European trade relationship.
Patient Portal Perceptions in an Urban Community Health Center Setting: Insights for Telehealth
Authors: Sakumoto Matthew , Ye Jiancheng , Kalu Richard , Jackson Kathryn L , Rittner Sarah , Long Timothy , Goel Mita Sanghavi , Walunas Theresa L
Published: November 2022

Introduction

Patient portals are the “front door” to telehealth - online scheduling, video visit links, and digital after visit summaries are often conveyed via the patient portal. Patient portal tools often require similar patient skills and attitudes as telehealth adoption. Analyzing patients’ perceptions and beliefs around this digital patient engagement tool may lead to insights regarding telehealth, particularly in historically underrepresented patient populations.

 

Methods

Participants from a Federally Qualified Health Center (FQHC) in Chicago, IL were surveyed on general technology use, healthcare-specific technology use, and barriers and facilitators to patient portal use.

 

Results

The 149 respondents (81% response rate) represented a unique population base with 96% African American, 74% with educational attainment of some college or less, and 48% with at least one chronic medical condition. Technology access and use were high with 78% computer ownership, 98% mobile phone ownership (with 75% smartphone ownership). In terms of patient portal perception, 75% rated Perceived Usefulness (U) as high. Perceived Ease of Use (E) domains similarly had 70% or higher agreement from patients, and potential barriers and facilitators in the Attitudes Toward Use (A) section included a preference to calling their doctor, and minority of patients viewing the portal as unsafe way to communication, too complicated to use, or taking too much time. Additional stratification analysis by demographic variables (age, gender, educational attainment, and number of chronic conditions) revealed differences in portal perception across the Usefulness, Ease of Use, and Attitudes domains.

 

Discussion

Insights from barriers, attitudes, and capacity to use patient portal tools deliver important insight into overall adoption of other digital health modalities, including telehealth. In an urban historically underserved patient population, technology access and use is quite high, and mobile phones access was nearly ubiquitous with a large majority using the internet function on their mobile device. Different age groups, genders, levels of educational attainment, or degree of multi-morbidity have different values and needs. Therefore, each subpopulation needs targeted messaging of different portal benefits.

 

Conclusion

Our research provides initial insights into patient-level factors influencing patient portal attitudes, with implications toward telehealth adoption. Demographic differences have a significant impact on attitudes toward technology adoption. Equitable uptake of portal and telehealth services will require tailored messaging, training, and multiple modes of communication, including web-based and mobile.
Fötal Gelişim Süresince Sığır Karaciğerindeki Sitokeratin 8 ve Sitokeratin 18 Proteinlerinin Dağılımı
Authors: Topaloğlu Uğur
Published: November 2022

Embriyonik gelişimin kontrolünde kritik rol alan sitokeratinler (CK), embriyogenezis esnasında epitel hücre gelişiminin değişen aşamalarında farklı keratinler şeklinde ekspresse edilir. CK8 ve CK18 proteinleri; çeşitli parankimatöz epitel başta olmak üzere basit epitel hücrelerinin primer keratin çifti olarak bilinmektedirler. Karaciğer; embriyonal dönemde kan yapımı ve kan hacmi regülasyonu, protein sentezi, bağışıklık sistemine katkı, büyüme sinyal yollarının endokrin kontrolü, metabolitleri depolama, safra salgısı ve detoksifikasyon gibi çok sayıda fizyolojik rollere sahiptir. Bu çalışma; CK8 ve CK18 proteinlerinin sığır fötal karaciğer hücrelerindeki dağılım ve lokalizasyonlarının immunohistokimyasal yolla belirlenmesi amacıyla yapılmıştır. Çalışmada özel kesimhanelerden temin edilen 27 adet sığır fetüsü kullanıldı. Yaşları belirlenen fetüsler; gebeliğin birinci (69-89 günlük / 9 fetüs), ikinci (99-178 / 9 fetüs) ve üçüncü (190-269 / 9 fetüs) dönemlerine ait olacak şekilde gruplandırıldı. Fetüslerden alınan karaciğer örnekleri 18 saat boyunca %10’luk formol-alkolde tespit edildi. Rutin histolojik prosedürlerden sonra elde edilen kesitlere immunohistokimyasal boyamalar yapıldı. Boyama sonucunda; CK8 ve CK18’in gebelik süresince safra kanalı epitel hücrelerinde çok güçlü seviyede ekspresse olduğu görüldü. Bununla birlikte hepatositlerde ise CK8 ve CK18’in gebelik dönemlerine göre değişen yoğunluklarda ekspresyon gösterdikleri belirlendi. Böylece CK8 ve CK18'in; sığır karaciğer gelişiminin kontrolü, hepatositlerin ve safra kanal epitel hücrelerinin bölünmesi, çoğalması ve farklılaşmaları gibi birçok role sahip olabilecekleri düşünüldü.
UPACARA ADAT HABBA KO'O RAI PADA SUKU SABU RAIJUA NTT.. SARA NARA KAHA IAKN KUPANG
Authors: Narakaha Sara
Published: November 2022

catatan ini berdasarkan penelitian kepada upacara adat masyarakat Sabu habba ko'o rai. HML
DIGITAL MARKETING IN NONPROFITS ORGANIZATION: ESSENTIAL TECHNIQUES FOR THE NEW ERA
Authors: Philips Victoria M
Published: November 2022

DIGITAL MARKETING IN NONPROFITS ORGANIZATION: ESSENTIAL TECHNIQUES FOR THE NEW ERA
Taking Without Giving: When Winning an Election Reduces Citizens' Support for Partisan Surrogate Representation
Authors: Allinger Tim Lars
Published: November 2022

Does winning or losing an election influence whether citizens expect their representative to cater to their voters or all citizens equally? The normative foundations of who a politician should represent have been debated by generations of scholars. However, we know little about how citizens view this debate despite their high relevance for democratic stability. I argue that winning causes citizens to perceive successful candidates as the representatives of their voters, whereas losers view them as partisan surrogates who should also cater to the interests of those who did not vote for them. Relying on a regression discontinuity design in close district races in three German national elections, I show that winning makes citizens less supportive of the idea of partisan surrogation. Hence, citizens appear to understand democracy in a fluid and self-serving way. Winners are therefore even more willing to exclude their political opponents from the representative process.
Differential expression of mitochondrial ribosomal protein L47 in triple negative breast cancer.
Authors: Mamoor Shahan
Published: November 2022

Women diagnosed with triple negative breast cancer can benefit neither from endocrine therapy nor from HER2-targeted therapies (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with triple negative breast cancer. We report here significant differential expression of the gene encoding mitochondrial ribosomal protein L47, MRPL47, when comparing the tumor cells of patients with triple negative breast cancer to normal mammary ductal cells (2). MRPL47 was also differentially expressed in the brain metastases of patients with metastatic breast cancer (3). MRPL47 mRNA was present at significantly increased quantities in TNBC tumor cells relative to normal mammary ductal cells. Analysis of human survival data revealed that expression of MRPL47 in primary tumors of the breast was correlated with overall survival in patients with breast cancer, while within triple negative breast cancer, primary tumor expression of MRPL47 was correlated with distant metastasis-free survival in patients with mesenchymal and luminal androgen receptor subtype disease. MRPL47 may be of relevance to initiation, maintenance or progression of triple negative breast cancers.
Biaya Produksi dan Penerimaan
Authors: Nurfadila Dayang
Published: November 2022

Pengertian biaya produksi menurut Soemarso (1996,295) : adalah biaya yang dibebankan dalam proses produksi selama suatu periode. Biaya ini terdiri dalam proses awal ditambah biaya pabrik. Termasuk dalam biaya-biaya yang dibebankan pada persediaan dalam proses akhir periode.Pengertian biaya produksi Menurut Mulyadi (1999,8) adalah pengorbanan sumber ekonomi, yang diukur dalam satuan uang, yang telah terjadi untuk tujuan tertentu.Penerimaan (revenue) adalah penerimaan produsen dari hasil penjualan produksinya.
PERUBAHAN SOSIAL TENTANG MODERNISASI DAN PERUBAHAN SOSIAL, GLOBALISASI DAN PERUBAHAN SOSIAL
Authors: Wangkanusa Seltia
Published: November 2022

PERUBAHAN SOSIAL TENTANG MODERNISASI DAN PERUBAHAN SOSIAL, GLOBALISASI DAN PERUBAHAN SOSIAL
Differential expression of peroxiredoxin 4 in triple negative breast cancer.
Authors: Mamoor Shahan
Published: November 2022

Women diagnosed with triple negative breast cancer can benefit neither from endocrine therapy nor from HER2-targeted therapies (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with triple negative breast cancer. We report here significant differential expression of the gene encoding peroxiredoxin 4, PRDX4, when comparing the tumor cells of patients with triple negative breast cancer to normal mammary ductal cells (2). PRDX4 was also differentially expressed in bulk tumor in human breast cancer (3). PRDX4 mRNA was present at significantly increased quantities in TNBC tumor cells relative to normal mammary ductal cells. Analysis of human survival data revealed that expression of PRDX4 in primary tumors of the breast was correlated with overall survival in patients with breast cancer, while within triple negative breast cancer, primary tumor expression of PRDX4 was correlated with distant metastasis-free survival in patients with luminal androgen receptor subtype and mesenchymal subtype disease. PRDX4 may be of relevance to initiation, maintenance or progression of triple negative breast cancers.
Call for collaboration: Benchmark datasets for landslide susceptibility zonation
Authors: Alvioli Massimiliano , Jacobs Liesbet , Loche Marco , Grohmann Carlos
Published: November 2022

Landslide susceptibility, the spatial likelihood of occurrence of landslides in a specific geographical area, is the subject of countless scientific publications. Different authors use heterogeneous data, and apply many different methods, mostly falling under the definition of statistical and/or machine learning approaches, with the common feature of considering many input variables and a single target output, denoting landslide presence. It is a classification problem: given N input variables assuming different values, each combination associated with a 0/1 possible outcome, a model should be trained with some dataset, tested to reproduce the target outcome, and eventually applied to unseen data possibly of practical application.At variance with many fields of science, no reference data exist to comparatively assess the performance of a given method for landslide susceptibility classification and mapping. We propose a benchmark dataset in Italy, extracted from a larger dataset covering the whole country and based on slope units as basic mapping units. The selected 7,360 slope units encompass an area of about 4,100 km^2 in Central Italy. The attribute table contains 26 columns, corresponding to predictors, and a binary column containing the landslide presence/absence flag.We release the dataset, along with a ``call for collaboration'', aimed at collecting a number of different calculations peformed with common input data, and establish a benchmark for landslide susceptibility models. Contributions to this collaboration will be presented at the 2023 European Geoscience Assembly, and collected in a journal publication authored by all of the contributors.
Beyond Playing 20 Questions with Nature: Integrative Experiment Design in the Social and Behavioral Sciences
Authors: Almaatouq Abdullah , Griffiths Thomas L. , Suchow Jordan W , Whiting Mark E , Evans James , Watts Duncan J
Published: November 2022

The dominant paradigm of experiments in the social and behavioral sciences views an experiment as a test of a theory, where the theory is assumed to generalize beyond the experiment’s specific conditions. According to this view, which Alan Newell once characterized as “playing twenty questions with nature,” theory is advanced one experiment at a time, and the integration of disparate findings is assumed to happen via the scientific publishing process. In this article, we argue that the process of integration is at best inefficient, and at worst it does not, in fact, occur. We further show that the challenge of integration cannot be adequately addressed by recently proposed reforms that focus on the reliability and replicability of individual findings, nor simply by conducting more or larger experiments. Rather, the problem arises from the imprecise nature of social and behavioral theories and, consequently, a lack of commensurability across experiments conducted under different conditions. Therefore, researchers must fundamentally rethink how they design experiments and how the experiments relate to theory. We specifically describe an alternative framework, integrative experiment design, which intrinsically promotes commensurability and continuous integration of knowledge. In this paradigm, researchers explicitly map the design space of possible experiments associated with a given research question, embracing many potentially relevant theories rather than focusing on just one. The researchers then iteratively generate theories and test them with experiments explicitly sampled from the design space, allowing results to be integrated across experiments. Given recent methodological and technological developments, we conclude that this approach is feasible and would generate more-reliable, more-cumulative empirical and theoretical knowledge than the current paradigm—and with far greater efficiency.
Conceptualizing Psychological Well-Being as a Process: Implications for Mobile Health Interventions
Authors: Heshmati Saeideh , Muth Chelsea , Roeser Robert W , Smyth Joshua M , Jamalabadi Hamidreza , Oravecz Zita
Published: November 2022

We introduce a theoretical framework for conceptualizing psychological well-being as a process that unfolds over short and longer time-scales. We argue that this framework can be especially useful for studying the change mechanisms in psychological well-being within the context of mobile Health (mHealth) interventions. Four lines of process-oriented research are considered within this framework to inform the scientific exploration of psychological well-being in the context of mHealth interventions. First, we explore psychological well-being functioning via person-specific characteristics. Second, we discuss key characteristics of change as a result of mHealth interventions. Third, we review evidence that interventions conduce towards psychological well-being through an underlying process of skill development through practice. Fourth, we discuss intervention response heterogeneity within this framework. The approach we outline is intended to articulate currently unanswered, process-oriented research questions about psychological well-being interventions, how they work, and a methodological path forward for exploring them.
Predictors of Academic Success in Undergraduate Medical Programs: The Roles of Divergent and Convergent Thinking
Authors: Alabbasi Ahmed M. Abdulla
Published: November 2022

In the last two decades, researchers in the medical field have attempted to predict academic success in undergraduate medical programs. Previous literature suggests several factors that predict academic success among Doctor of Medicine (MD) students, including metacognitive awareness, motivation, and emotional intelligence. However, the roles of divergent thinking (DT) and convergent thinking (CT) in MD students’ academic success are unclear. Moreover, because most definitions and theories of giftedness focus on K-12 education, little is known about gifted post-secondary learners, especially in specialized fields such as medicine. The present study aimed to bridge this gap by testing the role of DT and CT in predicting academic success among 84 gifted post-secondary MD learners. Three assessments were administered: (a) Raven’s Advanced Progressive Matrices Test, (b) the Watson-Glaser Critical Thinking Appraisal (WG-III), and (c) Alternative Uses Test. Cluster analysis suggested a distinct three-cluster solution. Correlational and multiple regression analyses showed that the originality dimension of DT and the Drawing Conclusions and Recognizing Assumptions subscales of the WG-III were significantly associated with and predicted the academic success of gifted undergraduate MD students, while IQ was not significantly related to students’ grade point average. Recommendations for future research are also discussed.
FORECAST OF THE MAIN PARAMETERS OF THE DEVELOPMENT OF FOREIGN TRADE IN THE STAVROPOL REGION
Authors: Vaitsekhovskaya Svetlana , Sidorova Darya , Orel Yulya , Cheremnykh Marina
Published: November 2022

Subject. Foreign trade is the most developed form of international economic relations and plays an important role in the socio-economic development of the state and regions. This article analyzes the key parameters of the development of foreign trade in the Stavropol Territory, substantiates the directions of development of foreign trade in the region, and makes a forecast of its development. Methodology. Trend analysis was used in the process of studying trends and forecasting the development of foreign trade. Results. In the current situation, the development of foreign economic activity in the region requires an increase in export potential, as well as its sectoral diversification. It is established that the preservation of the prevailing trends in the development of foreign trade activities of the region will lead to a slight expansion of exports with a drop in import volumes. This indicates the need for prompt intervention in this process on the basis of modernization of the export structure and expansion of its volumes. Conclusions. An increase in the number of export-oriented enterprises, the number of contracts concluded with foreign partners, and the expansion of the geography of foreign economic activity will have a positive impact on the development of the region's foreign trade. However, the implementation of these measures requires support from the state.
KEY SHORTCOMINGS AND METHODS OF DEVELOPMENT OF TAX AUDIT IN COMMERCIAL ORGANIZATIONS
Authors: Neschadimova Tatyana , Bezdolnaya Tatyana , Nesterenko Aleksey
Published: November 2022

Introduction. One of the problems of the development of tax audit in the country, as well as audit quality control systems, is the lack of certain development foundations. This leads to inconsistency of actions between the executive and legislative bodies. In this article, the concept of "tax audit" is considered from the point of view of an institutional approach. Goals. A comprehensive author's study of the problem of the development of tax audit in Russia. Development of a qualitatively new strategy and approaches to the organization of tax audit, which will focus primarily on tax optimization and minimizing the risks of organizations. Methodology. In the process of research, the problems are presented in a systematic form of key shortcomings and problems that hinder the potential and development of tax audit, logical, statistical analysis methods were used. Results. The sphere of tax audit needs to implement measures to eliminate shortcomings and develop measures to optimize them. Among the problems of the development of tax audit in the country, as well as audit quality control systems, is the lack of certain development foundations. The article presents the results of measures to improve the activities of auditors, the search and development of new ways to eliminate shortcomings, as well as developed measures for the effectiveness of post-verification work. Conclusions. It was concluded that when implementing a tax audit, it is the development of practical recommendations for improving the activities of auditors and audit organizations, which will reduce the risks of tax audits and claims by tax authorities to build the right strata.
LAUNDRY WASTEWATER TREATMENT USING ACTIVE CARBON MEDIA FROM COCONUT SHELL, MATOA SHAWS POWDER, IRON AND LINGUA WOOD
Authors: Mulyono Sri , Markus Arwam Hermanus , Mulyani Wiwik
Published: November 2022

Limbah laundry banyak mengandung sejumlah surfaktan, Carboxyl Methyl Cellulose (CMC), kalsium (Ca), phosfat (P), dan pemutih pakaian. Limbah tersebut menimbulkan dampak yang berbahaya bagi lingkungan. Tujuan penelitian ini untuk manganalisis penurunan kadar COD, TSS dan phospat air limbah laundry menggunakan karbon aktif dibandingkan dengan kontrol positif karbon aktif terstandar SNI. Rancangan penelitian adalah pertest posttest control group design. Air limbah dilakukan pengolahan pendahuluan melalui penyaringan terbuat dari susunan ijuk, koral, kerikil dan pasir. Selanjutnya dialirkan ke dalam karbon aktif untuk proses adsorpsi. Hasil penelitian menunjukkan karbon aktif mampu menurunkan parameter COD, TSS dan Phosfat. Ke-empat karbon aktif mampu menurunkan kadar COD, TSS dan Phosfat secara bermakna (p< 0,05). Penurunan terbaik adalah karbon aktif terstandar SNI dan bahan kayu besi, keduanya mempunyai kesamaan dalam menurunkan kadar COD, TSS dan Phosfat dibandingkan dengan karbon aktif dari bahan serpihan/serbuk kayu matoa, lingua dan tempurung kelapa. Kesimpulan dalam penelitian ini adalah ke-empat karbon aktif yang diujicobakan dalam mengolah air limbah laundry mampu menurunkan kadar COD, TSS dan phosfat secara bermakna. Karbon aktif yang terbuat dari kayu besi mampu menurunkan kadar COD, TSS dan phosfat paling tinggi, atau secara bermakna menyamai karbon aktif yang dijual dipasaran dengan standar SNI dalam menurunkan kadar COD, TSS dan phosfat.
ARTICLE REVIEW: THE USE OF AROMATHERAPY FOR ANOSMIA PATIENTS DURING THE COVID-19 PANDEMIC
Authors: Akbar Ali , Prasetya Priya Yuga
Published: November 2022

This study was conducted to determine the benefits of aromatherapy for anosmia people after exposure to COVID-19. Aromatherapy was often used for health therapy so it has the potential for the treatment of anosmia. This study is necessary to be done because there are a lot of anosmia sufferers and there is no effective way to treat it. The study of post-COVID-19 anosmia continues to evolve and more needs to be researched. This study was conducted by reviewing several literature studies originating from international and national journals, theses, and dissertations with a year limit of the last 10 years. From some literature it is known that aromatherapy can reduce the risk caused by anosmia. Aromatherapy can enter through the body's circulatory system and olfactory system through fragrances, It will affect the condition, memory, and psyche of a person. Although not very effective, further research on the benefits of aromatherapy for people with anosmia is necessary.
ODONATA DIVERSITY AT THE MOUNT PERMISAN NATURAL TOURISM PARK SOUTH BANGKA REGENCY, BANGKA BELITUNG
Authors: Kusumaningrum Ani Tias , Henri Henri , Saputra Herry Marta
Published: November 2022

Mount Permisan Natural Tourism Park, South Bangka regency is a conservation area that contains flora and fauna. The diversity of fauna in conservation areas is important to note because fauna can maintain the balance of natural ecosystems. This study aims to analyze the diversity of species and the effect of habitat characteristics on the Odonata population. Odonata sampling was carried out using an insect net randomly at a predetermined point in the left and right directions of the 100 m transect line. Identification was carried out at the Entomology Laboratory, Agricultural Quarantine Center Pangkalpinang, and compared with a comparison sample at the Zoology Laboratory, Biology Department, Universitas Bangka Belitung. Based on the research that has been done, found 14 species of Odonata from the sub-order Anisoptera and 11 species of damselfishes from the sub-order Zygoptera. The species diversity at that location was classified as moderate because H' was 1.56 to 2.05. The evenness value is high with a value of 0.62 to 0.90. The species of wealth (Margalef) is in the range of values from 2.55 to 2.75 which indicates the species richness of dragonflies in the Mount Permisan Natural Tourism Park index is classified as moderate.
Pengaruh Percieved Self-Efficacy terhadap Nasionalisme yang Dimediasi oleh Identitas Nasional
Authors: Baydhowi Baydhowi , Purwono Urip , Siswadi Ahmad Gimmy prathama , Saputra Wahyu , Iskandar TB Zulrizka
Published: November 2022

Nasionalisme merupakan tema penting dan selalu menarik perhatian di kalangan ilmu sosial untuk dikaji dan ditelti. Nasionalisme dianggap sebagai pemicu munculnya perilaku individu dan sosial tertentu. Meski begitu, sampai saat ini belum terjadi konsensus tentang nasionalisme, dalam konteks Indonesia misalnya, nasionalisme berbeda yang dikonsepsikan oleh kalangan ahli psikologi sosial. Fokus penelitian ini adalah pengujian model pengaruh perceived self-efficacy terhadap nasionalisme yang dimediasi oleh national identity. Penelitian ini melibatkan 804 mahasiswa dari 49 perguruan tinggi di Indonesia dengan teknik convinient sampling. Dari jumlah tersebut, laki laki berjumlah 278 dan perempuan sebanyak 526, dengan usia rata-rata adalah usia 22 tahun. Hasil analisis menunjukkan bahwa efficacy mempiliki pengaruh langsung pada nasionalisme dan national identity dan national identity berpengaruh secara signifikan terhadap nasionalisme. Self-efficacy juga berpengaruh secara signifikan terhadap nasionalime yang dimediasi oleh national identity. Hasil pengujian dengan sobel test juga menunjukkan perbedaan yang signifikan antara pengaruhÂ  pengaruh self-efficacy kepada nasionalisme secara langsung dan pengaruh secara tidak langsung. Berdasarkan hasil analisis national identity dapat menjelaskan adanya pengaruh self-efficacy terhadap nasionalisme.
Culture of information and information exchange in a public hospital: a study based on the information orientation model and social network analysis
Authors: Fortea-Cobo Gerando , González-Teruel Aurora
Published: November 2022

The structures of hospitals have evolved to make them centre on patients and their pathologies, with care procedures that are both interprofessional and interorganisational. This has given rise to work environments made up of teams obliged to collaborate in their problem-solving, with an essential focus on proper collaborative information behaviour (CIB). The aim was to study this behaviour in a clinical service of a hospital in relation to two aspects: information culture (IC) and the exchange of information. This entailed designing a two-part descriptive study. The first step was to administer a survey based on the information orientation model to know more about the service’s IC. The second phase focussed on the exchange of information from the perspective of an analysis of social networks. The main characteristic of IC was its proactive nature, especially in the use of information to improve one’s own work (mean = 4.58) and to respond to changes and new developments relating to work (mean = 4.18). The factor that least characterised IC was control, particularly in relation to knowledge of the objective of the activity itself (mean = 2.67) and the dispersion of information about hospital processes (mean = 2.64). On social networks, factors contrary to an interprofessional CIB were identified, such as homophily and low reciprocity in terms of relationships. In practice, the results identified a need to reinforce the perception of information as a resource, the proper use of which benefits job performance at both an individual and group level. A need to reinforce flows of internal hospital-related information was likewise evident. From a theoretical and methodological point of view, a useful tool is made available for diagnosing the collaborative information behaviour of an organisation and designing strategies to improve it.
Companies’ actions for more sustainable consumption
Authors: Ezdini Idrak
Published: November 2022

This paper investigates how companies may efficiently enhance customers’ sustainability awareness, first, by identifying the root causes of consumers’ low level of engagement in sustainability. Second, by understanding the most trustworthy sorts of advertising. Third, comprehending the SHIFT framework to find solutions based on the previous three steps. This paper proposes actions for businesses to improve their customer’s awareness of sustainability. Due to underlying root causes such as lack of knowledge about sustainability, lifestyle, sustainable products, and the activities businesses make to achieve sustainability goals, individuals with unsustainable lifestyles have wrong beliefs that impact their behaviours. As a result, companies should address the various root causes using the most trusted and influential factors, including social media, conferences, and word of mouth, to create a new consumer profile more involved in sustainability. Companies can use the SHIFT framework to make people feel and believe they are part of the problem and the solution. This study directs businesses towards solutions that address the underlying causes of the problem by addressing beliefs and feelings and engaging consumers.
Biyobozunur ZW21 Döküm Alaşımlarının Mikroyapı, Sertlik ve Korozyon Özelliklerini İncelenmesi
Authors: DJEBARI Kenza , TÜREN Yunus , AHLATCI Hayrettin , ELEN Levent
Published: November 2022

Bu çalışmada, Çinko (Zn) ve İtriyum (Y) içeren magnezyum (Mg) alaşımlarından ZW21 alaşımı kokıl kalıba dökülerek üretimleri yapılmıştır ve daha sonra mikroyapı, sertlik, korozyon ve aşınma özellikleri incelenmiştir. Üretilen alaşımların mikroyapı görüntüleri, zımparalama, parlatma ve dağlama gibi klasik metalografik yöntemleriyle yapılmıştır. Mikroyapı görüntüleri optik ve SEM cihazları ile alınmış ve EDX analizleri yapılmıştır. Metalografik olarak hazırlanan numunelerin sertlikleri Brinell sertlik test cihazı ile tespit edilmiştir. In vitro deneyleri gerçekleşebilmek için, potansiyodinamik polarizasyon ve daldırma testleri Hank sıvısında (36.5 ± 0.5ºC) sıcaklığında yapılmıştır. Ayrıca, korozif Aşınma testlerinde, sabit yük altında, sabit hız, mesafede, Hank sıvısında ileri-geri aşınma yöntemiyle yapılmıştır. XRD sonuçlarına göre I ve W fazlarının varlığı tespit edilmiştir. Malzemelerin sertliği 52.55 HV olarak bulunmuştur. Korozyon hızının zamanla yavaşladığı ve numune yüzeylerinde oksit film tabaksı oluşturulduğunu gözlenmiştir. Korozif aşınmada mesafeye bağlı olarak önemli bir ağırlık kaybı tespit edilmiştir.