bluuebunny/crossref_metadata_2025 huggingface dataset:
Leitura em português no meio digital e padrões funcionais visuais: estudo com rastreio visual-eye-tracking
Authors: Gil & Iolanda , Silva Nunes Maria Vânia
Published: December 2024

Introdução: Cada vez mais em populações com necessidades educativas especificas se utiliza na avaliação da leitura sistemas de rastreamento visual-eye-tracking para monitorizar em tempo real as suas competências de aprendizagem. Objetivos: Este estudo tem como objetivo identificar os padrões visuo-motores associados aos diferentes níveis de aprendizagem da leitura. Métodos: Participaram no estudo 12 crianças com necessidades educativas específicas a frequentar o segundo, terceiro e quarto anos de escolaridade, sem défice cognitivo ou de linguagem mas com perturbação neuromotora, Foi desenvolvido um sistema de avaliação em meio digital com recurso à ferramenta de rastreio visual e a estímulos de leitura de palavras, teste Avaliação da leitura para o português europeu e ainda pequenos textos adequados a cada nível de ensino. Foram avaliados os padrões visuais e sua correspondência ao nível de aquisições assim como o tempo despendido na leitura. Resultados: Os resultados obtidos nesta amostra revelaram padrões visuais correspondentes ao nível de aprendizagem melhorando o numero de fixações e a aumentando a velocidade à medida que os leitores iam adquirindo maior experiência na leitura. Conclusão: A facilidade de avaliação da leitura e a eficácia na identificação de padrões de rastreio visual proporcionam uma ferramenta útil aos profissionais para melhor adequarem e identificarem as dificuldades funcionais visuo-motoras e proporcionarem a estimulação adequada e atempada.
Comunicação interpessoal, resiliência e satisfação com a vida no ensino superior
Authors: Camati Pongolola Arminda Margarida , Da Silva Paím Edmar , Esteves de Almeida Sandra Luzia , Carvalho Pessoa dos Santos Renato Emanuel
Published: December 2024

A entrada e a frequência do ensino superior é sinónimo de alterações pessoais e sociais na vida dos estudantes, onde a comunicação interpessoal e a resiliência poderão contribuir para a satisfação com a vida. O presente estudo tem como objetivo verificar a influência da comunicação interpessoal e da resiliência na satisfação com a vida em alunos das Instituições de Ensino Superior. A metodologia utilizada é quantitativa, tendo sido aplicadas as Escalas de Satisfação com a Vida, da Competência em Comunicação Interpessoal e da Resiliência. A amostra, de natureza não probabilística por conveniência, foi constituída por 112 estudantes das Instituições de Ensino Superior da província de Benguela (Angola). Os resultados obtidos revelaram que a comunicação interpessoal afeta indiretamente a satisfação com a vida, sendo a resiliência uma variável mediadora. Apresentam-se, posteriormente, algumas limitações e implicações práticas, como a elaboração de programas de promoção de competências pessoais e sociais para alunos do ensino superior.
Resolución de problemas insight: propuesta de un método analítico útil para la enseñanza
Authors: Yousfi Boulaghmoudi Hanane , Sanjosé Vicente , Gómez Ferragud Carlos B.
Published: December 2024

Enseñar deliberadamente destrezas creativases difícil porque se convierten en analíticas o reproductivas para el alumnado en la siguiente tarea. El presente trabajo exploratorio tuvo como objeto proponer al profesorado un método para utilizar los problemas creativos de tipo insight en la instrucción. La propuesta se basa en métodos analíticos para facilitar al alumnado la generación de inferencias necesarias para la solución de este tipo de problemas, y también a relacionar las ideas, inferenciales y del enunciado, mediante el razonamiento lógico. Varios expertos generaron y consensuaron inferencias necesarias durante la resolución de algunos problemas insight. Luego, estas inferencias y las ideas del enunciado se relacionaron entre sí usando reglas lógicas. También se diseñaron rúbricas cuyos niveles se basan en la capacidad del alumnado para realizar, o no, ciertos procesos mentales determinados mediante las resoluciones analíticas. Estas rúbricas fueron validadas tentativamente con una muestra de 127 estudiantes de secundaria en 8º y 11º grados. Su uso permitió valorar sus avances y obstáculos específicos en aspectos como la descomposición de unidades o la relajación de restricciones, típicas de estos problemas insight, así como comparar entre cursos.
Viabilidad de un juego de mesa para abordar el miedo en la adultez temprana
Authors: Melo Alarcón Jesús David , Ortega Andrade Norma Angélica , Morales Tovar Anayely , García Cruz Rubén
Published: December 2024

Se reporta la aplicación de un juego de mesa diseñado con una metodología propuesta para la elaboración de juegos de mesa de uso clínico psicológico, con el objetivo de evidenciar su viabilidad en cuanto a utilidad, pertinencia, adecuación y relevancia en la identificación, expresión y regulación del miedo en la adultez temprana. Es un estudio exploratorio- descriptivo con un diseño no experimental transversal, en el que participaron 102 adultos mexicanos seleccionados mediante un muestreo no probabilístico. Se utilizó un cuestionario semiestructurado elaborado para los fines de este estudio. El análisis de los datos a través de distribución de frecuencias señala que el 87.3% de los participantes consideró que su experiencia con el juego fue buena; además el 99% de los participantes considera que el juego le fue de utilidad, principalmente porque ayudó a identificar y expresar la emoción del miedo, así como escuchar opiniones y compartir ideas relacionadas a la acción y la regulación del miedo, así mismo el 99% refirió que recomendaría el juego a otras personas de su edad. Se destaca que previo a la aplicación del juego, éste fue validado por jueces expertos. Por lo que se concluye que el juego de mesa diseñado para abordar el miedo es adecuado, pertinente, relevante y útil en la concientización de la naturalidad de la emoción y la importancia de expresarlo. En el diseño del juego se destaca la necesidad de apegarse a una metodología basada en evidencia científica que contribuya al diseño de este tipo de recursos de uso psicológico.
A perceção da mulher sobre a viol´ência obstétrica no ciclo gravídico puerperal: uma scoping review
Authors: Cordeiro Ana Catarina , Santos María José
Published: December 2024

Introdução: A violência obstétrica é um tipo de violência de género, caracterizada por qualquer tipo de abuso sofrido por mulheres durante a gravidez, parto e/ou puerpério. Portugal apresenta uma prevalência média de violência obstétrica três vezes superior à média europeia. Esta é uma temática que só se começou a investigar neste século, em especial na última década. No entanto, a maioria das investigações desenvolvidas são relacionadas com os profissionais de saúde e não abordam a violência na perspetiva das mulheres, pelo que estudar esta problemática nos parece relevante. Objetivo: Mapear a evidência científica sobre a forma como as mulheres percecionam a violência obstétrica durante a gravidez, parto e puerpério. Metodologia:Foi realizada uma Scoping Review, segundo o método proposto pelo Instituto Joanna Briggs, a partir da questão de pesquisa “Como é percecionada a violência obstétrica pelas mulheres durante a gravidez, parto e puerpério?”. Foram incluídos estudos publicados em português, inglês e espanhol. E a pesquisa foi realizada em várias bases de dados(CINAHL Complete, MEDLINE Complete, Cochrane Database of Systematic Reviews,e MedicLatina), tendo sido incluídos 17 artigos, aos quais se associaram três de literatura cinzenta. Resultados: As mulheres percecionam como violência obstétrica as manobras e/ou protocolos hospitalares consentidos ou não, os abusos verbais e humilhação/desrespeito, a negligência, abandono e falta de sensibilidade dos profissionais de saúde, restrição de presença de acompanhante, falta de conhecimento em relação à violência e ainda a falta de respeito por opções das mulheres. Conclusões: Os episódios de violência obstétrica são comuns durante todo o ciclo gravídico- puerperal, porém a perceção das puérperas é escassa e confirma-se mesmo o desconhecimento do termo, o que contribui para que seja um assunto subvalorizado, apesar das repercussões que pode ter no seu bem-estar.
Relato de experiência: processo educativo e promoção da saúde de máes de bebés com anquiloglossia
Authors: Kerckhoff dos Santos Andrea , Roseli Winkelmann Eliane , Caçador Anastácio Zélia
Published: December 2024

Este artigo trata-se de um relato de experiência sobre um trabalho desenvolvido com as mães de bebês que apresentavam dificuldade na mamada no seio, em especial os de anquiloglossia, moradoras na cidade de Vitória, Estado do Espírito Santo, Brasil, com distintos perfis socioeconómicos. O objetivo do trabalho foi promover a educação para a saúde com contextualização na facilitação à pega e organização sensorio-motora do binómio mãe-bebé. Participaram nos atendimentos 150 mães, com idades entre 15 e 45 anos. Foram realizadas sessões individuais de atendimento transdisciplinar e educação para a saúde, no período entre setembro de 2021 e agosto de 2022. Foram levantadas as principais dúvidas que as mães tinham sobre a mamada correta e eficiente, as quais foram esclarecidas no decorrer das sessões de atendimento assistencial e de educação para a saúde, com utilização de estratégia participativa e visual. Os termos técnicos foram descodificados para a linguagem popular. Com base nos temas trabalhados nas sessões, foi elaborada uma tarefa de casa com exercícios para a mãe e o bebé realizarem até à próxima sessão. A compreensão sobre o conteúdo foi validada com as mães a partir do momento em que se sentiam seguras para alta e no alcance dos critérios elaborados pela equipa transdisciplinar para cada caso. A experiência permitiu conhecer as peculiaridades do grupo e planear orientações compreensíveis e significativas com as mães.
Redes sociais, literacia em saude e a utilização da medicina alternativa e complementar: uma revisão narrativa
Authors: De Carvalho Angela , Galvão Ana , Anes Eugénia
Published: December 2024

Introdução: Uma das principais fontes de informações atualmente são as redes sociais devido a facilidade de acesso e a quantidade de dados que agrega. É um veículo que soma uma enorme quantidade de informação ou desinformação em saúde e às medicinas alternativas e complementares (MACs). Bons níveis de literacia em saúde (LS) são essenciais para a capacidade de discernir a qualidade e veracidade das informações obtidas antes da tomada de decisões individuais. Objetivo: Objetiva-se mapear a evidencia científica da associação entre a LS, a utilização das redes das redes sociais e utilização de MACs. Métodos: Revisão narrativa da literatura através das plataformas Google Acadêmico, PubMed e ScienceDirect, com 21 artigos incluídos para análise. Resultados: As redes sociais são amplamente utilizadas como fontes de informação para temas como a saúde e a MAC. A quantidade de desinformação presente nas redes sociais representa um perigo à saúde devido ao potencial de influenciar atitudes e potencializar comportamentos de risco. A LS aparece como um fator determinante e mediador da capacidade de discernir a qualidade das informações obtidas, influenciando a forma como os indivíduos processam e buscam informações das redes sociais, e suas atitudes perante as MACs. A LS, as redes sociais e as MACs estão associadas no que diz respeito à obtenção, interpretação e utilização de informações de saúde e de práticas alternativas e complementares. Conclusão: As MACs possibilitam diversas opções para além das convencionais, sendo vital que os indivíduos sejam informados de todas as opções disponíveis com os mais atualizados dados para poderem exercer seu direito de decisão da forma mais informada, contextualizada e segura possível.
Perceção de autoeficácia nos comportamentos de adesão ao papel de cuidador: relação com variaveis sociodemograficas
Authors: Ortiga Nogueira Juliana Sofia , Silva Pombo Soares Carla Alexandra , Pereira Gomes Nadirlene , De Sousa Carvalho Amâncio António
Published: December 2024

Introdução: O cuidador familiar num papel integral e complexo de cuidar do familiar dependente, desenvolve comportamentos no exercício desse papel, com autoeficácia variável. A autoeficácia assume-se pela capacidade de implementar estes comportamentos em situações novas e geradoras de stresse. É por isso um objeto relevante de estudo. Objetivo: Analisar a relação entre a perceção da autoeficácia nos comportamentos de adesão ao papel de cuidador familiar e algumas variáveis sociodemográficas. Metodologia: Trata-se de um estudo descritivo-correlacional, transversal e de abordagem quantitativa, no qual participaram 111 cuidadores informais familiares, utentes de uma Unidade de Saúde Familiar (USF), do Norte de Portugal. Na recolha de dados utilizámos um formulário, aplicado via telefone pelos investigadores, tendo sido tratados através do software SPSS 29.0, com recurso à estatística descritiva e inferencial. Resultados: Do total da amostra (n= 111) a maioria dos cuidadores informais, membros de uma família, era do sexo feminino (82,9%), pertencia ao grupo etário dos 45-64 anos (52,3%), detinha o estado civil de casado/união de facto (64,0%) e o maior grupo enquadrava-se na estimular a independência do familiar (70,3%), mas competentes na assistência ao familiar dependente na sua autovigilância (78,4%). A perceção da autoeficácia nos comportamentos de adesão ao papel de assistir ao familiar dependente na sua autovigilância difere entre os cuidadores familiares com diferente estado civil (Kruskal Wallis: p < 0,030), sendo que os cuidadores divorciados percecionaram maior competência, seguido pelos casados (68,00 > 57,06 pontos). Os solteiros percecionaram-se com a menor competência. Conclusões: Foram identificados os papéis em que os cuidadores familiares se percecionaram com menor competência, tornandose necessário que possa ser disponibilizada formação a estes cuidadores, a fim de melhorar a saúde e bem-estar do membro dependente e até do próprio cuidador familiar.
The impact of multilingualism on lateral thinking and critical thinking: how multilingualism is related to giftedness
Authors: Liverani Paola
Published: December 2024

This study, investigates how multilingualism influences lateral and critical thinking and its relationship to endowment. Lateral thinking involves generating different solutions, while critical thinking focuses on evaluating information. Both are essential for creativity and problem-solving. The research explores whether multilingual individuals exhibit improved skills in these areas compared to monolinguals, and how these skills relate to gifted traits such as creativity and advanced problem-solving. The study includes a literature review, standardized tests for lateral and critical thinking, and qualitative interviews. The results indicate that multilingualism increases cognitive flexibility, enhancing these thinking skills. In addition, multilingual individuals exhibit traits associated with endowment, suggesting a link between multilingualism and advanced cognitive abilities. The study’s findings underscore the importance of promoting multilingualism in education to foster cognitive and creative growth, and underscore the need for further research into its long-term effects on cognitive development and supergifting.
The problem of psychic reality before the anthropological turn: criticism by H. Plessner of the classical models of the psyche of R. Descartes, I.G. Fichte, E. Mach
Authors:   Ural Federal University named after the first President of Russia B.N. Yeltsin, Kyanganen Kirill V.
Published: December 2024

The article traces H. Plessner’s reasoning about the origins and content of psychic reality. The dependence of new European interpretations of the psyche on the dualism of R. Descartes is noted. Although W. Dilthey’s hermeneutics was adopted as a research methodology, its perception occurs as a result of a consistent analysis of several ways to solve the psychophysical problem — those proposed by R. Descartes, who defends the principle of psychophysical parallelism, by I.G. Fichte, being a representative of German idealistic philosophy, and by E. Mach, a positivist theorist. The article substantiates H. Plessner’s position regarding the insufficiency of dualistic concepts and the identification of the psyche with consciousness. The connection of E. Mach’s psychophysical monism with the Austrian philosophical tradition is noted. Also, the problematic nature of understanding the Other, as long as the Other is understood as an object of the material environment is noted. Using the example of modern researchers studying H. Plessner’s philosophical anthropology, the paper demonstrates the key role and contradictory nature of eccentricity in defining the status of the psyche. Four main questions that arise when analyzing psychic reality, including opposing trends in understanding the essence of eccentricity. On the one hand, it is proposed to bring anthropological interpretations closer to culturalist ones, and on the other — to naturalistic ones. The author of the article believes that the final answer about the nature of psychic reality depends on the solution of this question because, despite the presence of three determinants of human existence, the vector of modern research is determined, as a rule, by the priority of the body over the world of culture (Mitwelt), or vice versa. At the same time, the inner world turns out to be a derivative of bodily drives and the cultural environment.
Avaliação do uso da torta de filtro e biochar nos atributos do solo
Authors: Alves Marcelo Rodrigo , Souza Janardelly Gomes de
Published: December 2024

The aim of the present study was to evaluate the effect of different doses of filter cake and biochar on the chemical and biological attributes of the soil. Two experiments were set up, both in a completely randomized design, with 7 treatments and three replications, composed of: Experiment (SC) - soil without limestone + 1%, 2%, and 3% of filter cake (treatments SCTF1, SCTF2, and SCTF3, respectively) and, soil without limestone + 1%, 2%, and 3% of filter cake biochar (treatments SCBTF1, SCBTF2, and SCBTF3, respectively) plus the control treatment (TC); Experiment (CC) - soil with limestone + 1%, 2%, and 3% of filter cake (treatments CCTF1, CCTF2, and CCTF3, respectively) and, soil with limestone + 1%, 2%, and 3% of filter cake biochar (treatments CCBTF1, CCBTF2, and CCBTF3, respectively) plus the control treatment (TC). Subsequently, chemical (pH, OM, TOC, TN, P, K, Mg, Ca, Al, and H+Al) and biological (soil respiration, MBN, MBC, and dehydrogenase enzyme activity) analyses were performed. Variance and simple linear regression analyses (t-test at 5% probability) were conducted using the R software. For the comparison of means, the Scott-Knott test at 5% probability was used. The soil chemical attributes were influenced by the levels of TF and BTF, SC, and CC, showing higher values at the 3% level. For the biological attributes, SCTF3 was the most notable.
Sistema de Indicadores de Sustentabilidade Urbana para Pequenas Cidades
Authors: Silva Lilian Ferreira Cardoso da , Cândido Gesinaldo Ataíde , Lima Eduardo Rodrigues Viana de , Silveira José Augusto Ribeiro da
Published: December 2024

The use of urban sustainability indicator systems has been gaining increasing importance as a tool for creating and redefining public policies and urban management. The 2030 Agenda emphasizes the need to adapt these systems to local contexts, particularly in smaller cities. In this context, the article aims to propose an urban sustainability indicator system for a small city in the state of Paraíba, Brazil. Methodologically, this is an exploratory research with the collection of secondary and primary data in both quantitative and qualitative forms. The results obtained point to a set of 65 indicators aligned with the urbanization process within the territorial scope of the studied city, representing aspects that should be prioritized in public policies and urban management of the municipality, as well as being adaptable and applicable to other similar territorial contexts.
Análise Multicritério para Seleção de Técnicas Compensatórias de Drenagem Urbana e Recomendação de sua Distribuição Espacial para a Cidade de Itajubá – MG
Authors: Macedo Marina Batalini de , Rodrigues Ana Júlia
Published: December 2024

Objective - This study evaluated the applicability of the integration of multicriteria analysis methods with Geographic Information System tools to identify suitable locations for the implementation of sustainable drainage measures.
Methodology – The multicriteria analysis method known as Analytical Hierarchical Process (AHP) was employed alongside QGIS software to evaluate bioretention, detention basins, permeable pavements, individual reservoirs, and green/storage roofs in a case study conducted in the city of Itajubá, MG.
Originality/relevance – Decision-makers continue to face challenges in identifying optimal locations for implementing sustainable urban drainage techniques that account for technical and spatial constraints, posing a persistent barrier to their widespread adoption.
Results – It was observed that detention basins are more suitable for peripheral areas and individual reservoirs and green/storage roofs systems for urban areas. Bioretention was not very suitable for urban areas, due to space restrictions. The most influential criterion overall was “solid input”, except for the green/storage roof system, which prioritized the resident population.
Social and environmental contributions - This work provides a consolidated methodology for creating maps that can be used by decision makers to choose the most suitable locations for the application of sustainable urban drainage techniques, contributing to the reduction of flooding and diffuse pollution in urban centers.
Impactos sociais do desastre socioambiental provocado pela BRASKEM S.A em Maceió-Alagoas
Authors: Fragoso Amanda Carolina Simões , Gonçalves Rafael Soares
Published: December 2024

This article aims to discuss the social impacts of the socio-environmental disaster caused by Braskem S.A.'s salt mining activities in Maceió, AL. The study was conducted through a literature review. Testimonies from residents were identified in reports, articles, and academic works, as well as in newspaper reports (print and electronic media, both written and video formats). The article also incorporates the firsthand experience of the first author, a resident of the city and directly affected by the disaster. The text analyzes the social and emotional damages to displaced populations and residents in areas impacted by land subsidence caused by the underground collapse of the mines. Numerous social impacts were identified, including the loss of property and income, the closure of public facilities, the disruption of social bonds, and the emergence of emotional problems. The case should be considered a socio-environmental crime of significant impact, raising questions about possible forms of economic and social reparations involving the Maceió population, both directly and indirectly.
Advancing drug development for SSc by prioritising findings from human genetic association studies v1
Authors: Hughes Michael , not provided r.providencia
Published: December 2024

This protocol describes in the detail the processes for an evidence synthesis on drug repurposing opportunities and potentially druggable targets for systemic sclerosis (SSc) with support from human genetics, by integrating the available evidence with bioinformatics sources.
Nanopore amplicon sequencing withR10.4.1 flow cells v1
Authors: Li Teng , Wang Miao
Published: December 2024

This protocol describes an updated method for Nanopore amplicon sequencing withR10.4.1 flow cells, building upon the original protocol "Nanopore amplicon sequencing" by Yoshiyuki Matsuo (DOI: https://dx.doi.org/10.17504/protocols.io.8epv5zrodv1b/v4). The two-step PCR approach enables sequencing with a user-defined inner primer set combined with barcoded outer primers, leveraging rapid adapter attachment chemistry. With the latest version of flow cells and sequencing kits, Nanopore sequencing can achieve Q20 accuracy. This method supports a wide range of applications, including microbiome profiling, taxonomy identification (e.g., COI gene for animals), phylogenetic analysis, and identifying genetic variations in targeted loci. Since the R9.4.1 flow cell and the PCR Barcoding Kit SQK-PBK004 used in the original protocol have been discontinued, and Oxford Nanopore Technologies has decided not to release a direct upgrade for the SQK-PBK004 kit, this protocol has been revised for compatibility with the latest R10.4.1 flow cell and the cDNA-PCR Barcoding Kit SQK-PCB114.24. The updates include modifications to reagent names and volumes, PCR cycle settings, and library preparation steps to align with the specifications of the new flow cell and kit. These changes ensure that the method remains robust and accessible while leveraging the enhanced accuracy and efficiency of the latest Nanopore sequencing technology. We also use the Flongle flow cell FLO-FLG114 as an example, which is ideal for smaller-scale experiments or pilot studies, as well as Nanopore didn't provide a specific Flongle protocol for cDNA-PCR Barcoding Kit SQK-PCB114.24.
A simple protocol for sampling environmental DNA from flowing waters at remote field sites v1
Authors: A.B. Harings Maggie , Schoen Erik , Hill Justin , Reece Kristen , R Kamermans Cron Brandi , Andrés López J.
Published: December 2024

We developed this protocol in 2021 to for standardized eDNA sample collection at salmon escapement assessment sites in non-glacial, boreal rivers in the Arctic-Yukon-Kuskokwim Region of Alaska. The protocol is designed to allow researchers without any prior training in molecular techniques to collect eDNA samples and store them for up to several months at remote field camps without access to freezers or refrigeration. The protocol is also designed to minimize contamination at sites where eDNA sampling is conducted by personnel who may have also handled the target species that same day. We designed and implemented this protocol as part of a research project that tested eDNA quantification as a potential approach to estimating the abundance of salmon spawners in rivers. However, the protocol is flexible and could be applied in other projects involving eDNA sample collection from flowing waters at remote sites. We filtered duplicate samples of river water once daily and collected a weekly field blank to assess potential contamination in samples. The levels of replication and sampling frequency can be adjusted to fit the research question as well as budgetary and logistical constraints of the project
“The Russian Idea” by Vladimir Solovyov and “On the Russian Idea” by Vyacheslav Ivanov: the Rhetoric of Prophetic Word and the Thesaurus of Thought
Authors:   Saint Petersburg State University, Titarenko S.D.
Published: December 2024

The paper examines the significance of the philosophy of all-unity and moral philosophy of Vladimir Solovyov based on the little-studied problem of comparative analysis of his essay “The Russian Idea” (1888) and Vyacheslav Ivanov’s essay “On the Russian Idea” (1909). Ivanov's essay was supplemented and published in Germany in German language under the title “The Russian Idea” (“Die Russische Idee”) (1930). Both essays address the issues of overcoming the crisis of humanistic and religious consciousness in Russia and Europe. The cultural-philosophical ideas and thesaurus of the essays are analyzed. The thesaurus approach, as a basis for comparative analysis, allows for the identification of constants in the thinking of Solovyov and Ivanov, which are based on the concepts of “the Russian idea”, “Russia and Europe”, “national idea and nationalism”, “religious consciousness”, “religious culture and all-world unity” and “Christian revival”. It is shown that in Ivanov's understanding, the concept of “the Russian idea” represents the ideal of a revived Christian self-consciousness, similar to that of Solovyov and his predecessor F.M. Dostoevsky. It serves as “the first principle” of religious and national self-determination and stands in opposition to the notion of “nationalism”. These issues are also addressed in Ivanov's essay “The Religious Case of Vladimir Solovyov” (1916), his collection of essays “Native and Universal” (1917), and his book “Dostoevsky: Tragedy – Myth – Mysticism” (1932). Analyzing the thesaurus of Solovyov's and Ivanov's essays leads to the conclusion that they are characterized by rhetoric based on universal words, which are united by the symbolic significance of the concept of “the Russian idea”. Its meaning is determined by the humanistic and religious mission of Russia, which is important for preserving a space of cultural and religious unity between Russia and Europe, overcoming enmity among nations, nationalism, and authoritarianism. A comparative analysis is conducted between the ideas of Solovyov and Ivanov and the problematic aspects of Oswald Spengler's book “The Decline of the West” (1918–1922). The cultural-philosophical prophecy of Spengler regarding the cyclicality and “decline” of European culture is considered. The problem of the revival of Christian culture on the basis of the “Russian idea”, which represents the direction of thought of Solovyov, Ivanov, Dostoevsky, is of interest for understanding the meaning of Solovyov's Christian universalism, the ideas of which are relevant today.
Heparina de baixo peso molecular na cicatrização de lesões tissulares: protocolo de revisão sistemática
Authors: Baptista Carla Teles de Carvalho Herdy , Oliveira Bianca Campos , Oliveira Beatriz Guitton Renaud Baptista de
Published: December 2024

Objetivo: investigar a efetividade do uso da heparina de baixo peso molecular na cicatrização de lesões tissulares. Método: será realizado uma revisão sistemática da literatura conduzida pelas recomendações do Joanna Briggs Institute (JBI) e checklist PRISMA Extension for Systematic Reviews (Reporting Items for Systematic Reviews and Meta-Analyses). Bases de dados: MEDLINE (via PubMed), Embase, LILACS, CINAHL, Scopus e Web of Science. Pergunta de pesquisa: Pacientes com lesões em tecido cutâneo em uso de heparina de baixo peso molecular apresentam melhora na cicatrização quando comparada às terapias convencionais? Critério de inclusão: Ensaios clínicos randomizados e quase experimentais, que avaliam o uso da Heparina de Baixo Peso Molecular na cicatrização de lesões em seres humanos de 18 anos ou mais com lesões tissulares.
Degradation Testing of Thermoelectrics Due to Temperature
Authors: Pulido Julio , Manchette Kit
Published: December 2024

In today's global environment, accelerated life testing (ALT) is becoming a competitive advantage when time spent from the conceptual stage to final product development needs to be minimized. Using ALT techniques for semiconductors and structural applications has substantial challenges when defining the thermal fatigue life-stress relationship to represent actual field performance. Helpful strategies to address such common problems using ALT are presented for faster ALT planning. Test examples from the refrigeration industry are used for this demonstration. The tests and analyses performed effectively increased the degree of reliability improvement and reduced the total number of test hours, resulting in a shorter design cycle.
Reliability Focused Six Sigma (RFSS) Approach
Authors: Urdhwareshe Hemant , Prabhu Chetan
Published: December 2024

One of the major objectives of a Six Sigma program is to make defect-free, reliable products. Rightfully, customers expect more reliable products from companies adopting a Six Sigma approach. However, many companies implementing Six Sigma are unable to achieve this objective, and the impact of unreliable products can be multifold. The worst effect is reduced customer preference toward a company's product due to loss of confidence. Affected companies also can lose market share and can experience significant adverse impacts on reputation. While manufacture and sale of unreliable products could arise from poor execution of Six Sigma or other similar improvement approaches, it could also result from a lack of understanding of both reliability metrics and the toolset. Moreover, most companies prioritize Six Sigma projects based on cost and profit impacts on business. Unfortunately, the complete cost of poor reliability and durability does not get captured. As a result, reliability and durability improvement projects are frequently designated as low priority at companies.

The Six Sigma Body of Knowledge (SSBOK) for Black Belts in most companies usually does not include life data analysis and other reliability tools. SSBOK does include other tools, such as SPC, MSA, FMEA, Design of Experiments, Hypothesis Tests, ANOVA, and so forth, but, as we know, what we do not measure we cannot improve! Most of the Six Sigma books also do not include reliability tools. Conventional procedures for assessing baseline performance do not include establishment of a reliability requirement. Also, the normal distribution rarely applies to reliability data! Life data contains failure and survival points, which makes analysis more complicated. Under these circumstances, improvement project leaders need to learn and master a set of reliability tools. We call this modified approach ‘Reliability Focused Six Sigma’ (RFSS). In this paper, we will share two case studies to illustrate the RFSS approach. These case studies are based on the personal experience of the authors, and company names and more details cannot be disclosed.
The Next Chapter in the History of International Cleanroom Standards
Authors: Matthews Richard A. , Dixon-Heathman Anne Marie
Published: December 2024

The development of cleanroom standards began in the United States Air Force and has grown into a global industry with the founding of ISO Technical Committee 209, Cleanrooms and associated controlled environments. The Institute of Environmental Sciences and Technology has played a vital role from the beginning.
Key Elements of a Successful Cleaning and Disinfection Program
Authors: Polarine James N. , Dixon-Heathman Anne Marie
Published: December 2024

Maintaining and improving cleanroom manufacturing operations are required to ensure quality products. In today's world, there are many challenges facing cleanrooms and controlled environments and their support areas. Proper cleaning and sanitization of all cleanrooms and controlled environments are key to maintaining these facilities at the level for which they were designed.
Evaluation of biodistribution of Riboplatin, a Pt(IV) double prodrug based on cisplatin, using fluorescent visualization
Authors: Spektor Daniil V. , Akasov Roman A. , Khaidukov Evgeny V. , Demina Polina A. , Stepanov Maksim E. , Babayeva Gulyalek , Pokrovsky V. S. , Lapanik Anna D. , Naumova Alena D. , Lopukhov Anton V. , Klyachko Natalia  L. , Kuzmichev Ilya A. , Semkina Alevtina S. , Dubenskiy Aleksander S. , Beloglazkina Elena K. , Krasnovskaya Olga O.
Published: December 2024

BACKGROUND: Developing new platinum-based antitumor agents with improved efficacy and reduced toxicity remains a critical challenge. One promising approach is the synthesis of Pt(IV) prodrugs, such as precursor complexes of cisplatin and its analogs, which release active Pt(II) directly into the intracellular environment of malignant cells. To determine the optimal administration route for these new platinum-based drugs in vivo, it is essential to study their acute toxicity and biodistribution in vital organs.
AIM: To evaluate the tolerability, acute toxicity, biodistribution, and accumulation in breast tumors of Riboplatin and its liposomal formulation.
MATERIALS AND METHODS: The study was conducted at Moscow Pedagogical State University in female BALB/c mice (healthy or bearing transplanted breast adenocarcinoma EMT-6) and in immunodeficient BALB/c nude mice (bearing human breast adenocarcinoma SK-BR-3). The fluorescence imaging and inductively coupled plasma mass spectrometry were used.
RESULTS: A single dose (up to 48 mg/kg) of either water solution or liposomal formulation of Riboplatin did not cause any decrease of body weight in mice. The animals tolerated the dose 48 mg/kg of the drug, whereas the body weight decreased by less than 5% within 3 days. The distribution of Riboplatin and of its liposomal formulation over the body organs was assessed in BALB/c nude mice using fluorescence imaging and inductively coupled plasma mass spectrometry. Both forms provided Riboplatin delivering to EMT-6 tumor. Riboplatin in the form of water solution was predominantly excreted through liver and kidney, while the liposomal formulation lewd to drug accumulation in the spleen.
CONCLUSION: Riboplatin is a Pt(IV) prodrug with good tolerability, reduced toxicity compared with cisplatin, with effective accumulation in malignant breast tumors. The opportunity of assessing Riboplatin biodistribution in vivo in EMT-6 and SK-BR-3 tumor lines using fluorescence imaging has been demonstrated. Significant Riboplatin accumulation in EMT-6 tumors suggests the possibility of riboflavin-specific uptake.
The claudin family of proteins in the pathogenesis and treatment of malignancies: current insights and future prospects
Authors: Boichuk Sergei V. , Bikinieva Firyuza F. , Kopnin Pavel B.
Published: December 2024

This review presents data concerning claudins, the proteins of tight junctions, and their role in the pathogenesis and therapy of malignancies. Particular attention is paid to the variability in claudin expression levels, their intracellular localization in tumors, and the prognostic significance of these variations in cancer. The review highlights the role of claudins in metastatic spread, invasion, and tumor cell resistance to antitumor drug therapy. Moreover, the potential of claudins as targets for novel diagnostic and treatment methods for malignant neoplasms is also discussed.
Viral microRNA in HPV16-associated cervical cancer: expression, diagnostic potential, and biological functions
Authors: Elkina Nadezhda V. , Fedorova Mariya D. , Faskhutdinov Radik S. , Iurchenko Iuliia O. , Zhordania Kirill I. , Mustafina Ekaterina A. , Pavlova Larisa S. , Vinokurova Svetlana V.
Published: December 2024

BACKGROUND: Cervical cancer (CC) is the fourth most common cancer among women worldwide in terms of incidence and mortality. High-risk human papillomaviruses (HPVs) are etiologic factor of CC in more than 90% of cases, with type 16 HPV (HPV16) revealed in 50% of cancers. Dysregulation of expression of viral oncogenes E6 and E7 is the main cause of malignant transformation in infected cervical epithelial cells. The mechanisms of impaired expression of these genes are still underexplored. The dysfunction of viral microRNAs may be among the underlying factors.
AIM: To analyze the expression of HPV16-associated microRNA-H1 and microRNA-H2 in cervical cancer specimens, evaluate the correlation of their expression to viral load and overall patient survival, and analyze in silico their potential viral and cellular targets.
MATERIALS AND METHODS: The expression of HPV16 microRNA-H1 and HPV16 microRNA-H2 was evaluated in the real-time polymerase chain reaction. With this purpose, small RNAs were isolated from 36 specimens of HPV16-positive squamous cell carcinomas of the cervix. Further, the viral load was assessed after calculating the value of HPV16 DNA copies per cell. The association between microRNA expression and the viral load was evaluated using the nonparametric Spearman’s correlation coefficient. Kaplan-Meier curves were plotted to analyze the dependence of 5-year overall survival on the level of viral microRNA expression. The miRanda algorithm and online services mirDB, MR-microT and TargetScan Custom 5.2 were used for in silico search of theoretical microRNA targets.
RESULTS: MicroRNA-H1 expression was revealed in 33 of 38 specimens (86.8%), microRNA-H2 was detected in 37 of 38 specimens (97.4%) of HPV16-positive cervical cancer. There was a positive correlation between both microRNA-H1 (r=0.36, p=0.042) and microRNA-H2 (r=0.51, p=0.001) expression and HPV16 viral load. Higher level of expression of viral microRNA-H1 and microRNA-H2 tended to correlate with better overall patient survival. The theoretical microRNA-H1 (E7, E2, E5, L2 and URR) and microRNA-H2 (E1, E2, E5, L2, L1, URR) targets in the HPV16 genome were identified in silico, as well as theoretical cellular targets indicating possible regulation of cellular signaling pathways by means of viral microRNAs, both controlling normal viral cycle and promoting tumor transformation.
CONCLUSION: The results of this study demonstrate promising further investigation of the functions of viral microRNAs in relation with the infectious process and virus-induced malignant transformation, and their potential importance in the diagnosis of HPV16-associated cancers.
Innovations in Soil Health Monitoring: Role of Advanced Sensor Technologies and Remote Sensing
Authors: Huere-Peña Jorge Luis , Castrejon-Valdez Manuel , Castañeda-Campos Cesar , Leon-Gomez Rodolfo , Mateu-Mateo Walter Augusto , Bautista-Gómez Rolando , Arostegui-León Edward , Dueñas-Jurado Carlos , Ceenti-Chancha Edwin Javier , Rojas-Felipe Edwin , Yaulilahua-Huacho Russbelt
Published: December 2024

Soil health monitoring is essential for sustainable agricultural practices and effective environmental management. Recent sensor technologies and remote sensing innovations have transformed how we assess soil health, providing real-time and precise data that enhance decision-making processes. This review focuses on integrating advanced sensor technologies, like Internet of Things (IoT) devices, alongside remote sensing techniques, including drones and satellite imagery, in soil science. These technologies enable continuous monitoring of critical soil parameters, such as moisture levels and nutrient content, significantly improving the accuracy and efficiency of soil health evaluations. Additionally, remote sensing provides a comprehensive overview of soil conditions across large areas, allowing for the identification of spatial patterns and temporal changes that traditional methods may overlook. Various case studies from agricultural and environmental projects demonstrate the practical benefits and the challenges of implementing these innovations. The article also discusses future trends and potential obstacles, highlighting the need for further research and development to exploit these technologies' capabilities fully. Ultimately, advanced sensors and remote sensing promise to improve soil health monitoring, contributing to more sustainable and productive agricultural systems.
Medicinal value of Lippia multiflora Mondenke flowers in the fight of oral and dental infections
Authors: Rouamba Ablassé , Kamboulé Eric Wienybè , Ouedraogo Vincent , Compaoré Eli , Kiendrebeogo Martin
Published: December 2024

Oral infections pose a significant global health issue. This study assessed the antibacterial properties of methanol and dichloromethane extracts from Lippia multiflora flowers against Staphylococcus aureus ATCC 43300 and Streptococcus mutans ATCC 2517, two bacteria known to cause oral infections. The study measured the ability of these flower extracts to inhibit the growth and biofilm formation of S. aureus and S. mutans using micro-dilution and crystal violet methods, respectively. Additionally, we analyzed the presence of secondary metabolites in the extracts both qualitatively and quantitatively. The antioxidant properties of the extracts were evaluated using DPPH, ABTS, and FRAP methods. The results indicated that the dichloromethane extract demonstrated a more substantial bactericidal effect than the methanolic extract against S. mutans and S. aureus, with minimal bactericidal concentrations of 0.25 ± 0.02 mg/mL and 3.13 ± 0.30 mg/mL, respectively. Furthermore, the dichloromethane extract at a 100 µg/mL concentration exhibited the highest anti-biofilm activity against both S. aureus and S. mutans. Phytochemical screening revealed the presence of alkaloids, flavonoids, quinones, and tannins in both extracts. The total phenolic content was higher in the methanolic extract (49.57 ± 2.74 mg EAG/100 mg) compared to the dichloromethane extract (25.71 ± 0.39 mg EAG/100 mg). Similarly, the total flavonoid content was more significant in the methanolic extract (2.87 ± 0.049 mg EQ/100 mg) than in the dichloromethane extract (2.24 ± 0.02 mg EQ/100 mg). The methanolic extract also exhibited superior anti-DPPH and anti-ABTS activities, as well as a higher Fe (III) reduction potential than the dichloromethane extract (P < 0.05). These findings suggest that L. multiflora flowers could serve as a potential source of antimicrobial agents for combating oral infections.
Zeolite-based nano phosphatic fertilizer for enhancing phosphorus availability in acidic soils of Assam, India
Authors: Pachani Sukanya , Kandali Gayatri Goswami , Medhi Binoy Kumar , Saikia Lakshi , Basumatary Anjali , Begum Mahima , Bhuyan Samikhya
Published: December 2024

Considering the fixation and low availability of conventional phosphatic fertilizer in acidic soil, zeolite based nano phosphatic fertilizer was synthesized to investigate its release characteristics in acidic soil system via invitro studies. Result revealed that surface modification through a cationic surfactant improved the adsorption capacity of zeolite for phosphorus by 60%. Under the incubation study, the zeolite based nano phosphatic fertilizer sustained the release of phosphorous up to 90 days of incubation against 32 days under conventional SSP. The 100% replacement of RDP through nano fertilizer registered the maximum release of P in soil up to 9.36 mg/kg which was 23.80% higher than conventional SSP (7.56 mg/kg). The study release kinetics also revealed parabolic diffusion equation (3.012 µg/g/day) as the most suitable module for describing the P release as compared to other kinetic modules. Thus, zeolite can be used as carrier material for preparation of nano fertilizer for sustainable release of P for longer period of time under acidic soil.
Sustainable nutrient management and agricultural productivity in chernozem soils of the Kostanay Region, Kazakhstan
Authors: Zharlygassov Zhenis , Kalimov Niyazbek , Ansabayeva Assiya , Zharlygassov Zhaxylyk , Moskvicheva Elena , İslamzade Rahila , Ay Abdurrahman , Akça İzzet , Kızılkaya Rıdvan
Published: December 2024

Chernozem soils, known for their high organic matter and fertility, are crucial for agricultural productivity in northern Kazakhstan's Kostanay region. This study evaluated the physical, chemical, and biological properties of these soils to assess their suitability for crop production and propose sustainable management practices. Soil samples were collected from 0-20 cm depths across various locations to represent the region's main nutrient profile. Physical analyses included texture determination, while chemical analyses measured pH, electrical conductivity (EC), organic matter, and nutrient levels (N, P, K, Ca, Mg, Fe, Cu, Zn, and Mn) using standard methods. Biological assessments focused on microbial biomass carbon (Cmic), basal soil respiration (BSR), dehydrogenase and catalase activities, as well as Cmic: Corg and metabolic quotient (qCO₂) ratios. Results indicated high organic matter content (mean 4.49%), sufficient total nitrogen (>0.25%), and high levels of potassium and calcium. However, phosphorus levels were low (