bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficient segmentation of active and inactive plaques in FLAIR-images using DeepLabV3Plus SE with efficientnetb0 backbone in multiple sclerosis
Authors: Naeeni Davarani Mahsa , Arian Darestani Ali , Guillen Cañas Virginia , Azimi Hossein , Havadaragh Sanaz Heydari , Hashemi Hasan , Harirchian Mohammd Hossein
Published: July 2024

This research paper introduces an efficient approach for the segmentation of active and inactive plaques within Fluid-attenuated inversion recovery (FLAIR) images, employing a convolutional neural network (CNN) model known as DeepLabV3Plus SE with the EfficientNetB0 backbone in Multiple sclerosis (MS), and demonstrates its superior performance compared to other CNN architectures. The study encompasses various critical components, including dataset pre-processing techniques, the utilization of the Squeeze and Excitation Network (SE-Block), and the atrous spatial separable pyramid Block to enhance segmentation capabilities. Detailed descriptions of pre-processing procedures, such as removing the cranial bone segment, image resizing, and normalization, are provided. This study analyzed a cross-sectional cohort of 100 MS patients with active brain plaques, examining 5000 MRI slices. After filtering, 1500 slices were utilized for labeling and deep learning. The training process adopts the dice coefficient as the loss function and utilizes Adam optimization. The study evaluated the model's performance using multiple metrics, including intersection over union (IOU), Dice Score, Precision, Recall, and F1-Score, and offers a comparative analysis with other CNN architectures. Results demonstrate the superior segmentation ability of the proposed model, as evidenced by an IOU of 69.87, Dice Score of 76.24, Precision of 88.89, Recall of 73.52, and F1-Score of 80.47 for the DeepLabV3+SE_EfficientNetB0 model. This research contributes to the advancement of plaque segmentation in FLAIR images and offers a compelling approach with substantial potential for medical image analysis and diagnosis.
Modeling and self-supporting printing simulation of fuse filament fabrication
Authors: Ao Xiaohui , Lin Shengxiang , Liu Jianhua , Xia Huanxiong , Meng Junfeng
Published: July 2024

This study presented a comprehensive computational fluid dynamics-based model for fused filament fabrication (FFF) three-dimensional (3D) printing multiphase and multiphysics coupling. A model based on the framework of computational fluid dynamics was built, utilizing the front-tracking method for high precision of multiphase material interfaces, a fully resolved simulation at the mesoscale explores the underlying physical mechanism of the self-supported horizontal printing. The study investigated the influence of printing temperature and velocity on the FFF process, exhibiting a certain self-supporting forming ability over a specific range. The results indicated that during the printing of large-span horizontal extension structures, the bridge deck material transitions from initial straight extension to sagging deformation, ultimately adopting a curved shape. The straight extension distance is inversely proportional to the depth of the sagging deformation. Additionally, the study revealed that printing temperature primarily affected the curing time of the molten material, while printing velocity fundamentally affected the relaxation time of both thermal and dynamic characteristics of the material.
18F-FDG PET/CT metabolic parameters can semi-quantitatively evaluate the nature of the heart and pericardial masses: a retrospective study
Authors: Hu Xianwen , Yang Peiqing , Pan Dongfeng , Wang Pan
Published: July 2024

The objective of this study was to evaluate semi-quantitatively the diagnostic performance of PET/CT metabolic parameters in differentiating benign or malignant cardiac or pericardial masses. A total of forty-one patients with newly diagnosed cardiac/pericardial masses who underwent 18F-FDG PET/CT were recruited. PET/CT metabolic parameters including the maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), total lesion glycolysis (TLG), tumor metabolic volume (MTV), the maximum tumor-to-mediastinal background ratio (TMR) and the maximum tumor-to-liver background ratio (TLR) is measured or calculated to evaluate the benign or malignant nature of cardiac/pericardial masses. Compared with benign cardiac/pericardial lesions, cardiac/pericardial malignancies had higher SUVmax, SUVmean, TLG, MTV, TMR, and TLR. All these PET/CT metabolic parameters showed high diagnostic performance in semi-quantitative evaluation of benign or malignant cardiac or pericardial masses, and SUVmean and MTV had the highest diagnostic accuracy. Therefore, PET/CT metabolic parameters can semi-quantitatively evaluate the benign or malignant cardiac/pericardial masses.
Effect of caspase inhibitors on hemodynamics and inflammatory factors in ARDS model rats
Authors: Liu Aiming , Tian Fei , Zhou Yaqing , Pu Zunguo
Published: July 2024

To study the effects of caspase inhibitors on hemodynamics and inflammatory factors in acute respiratory distress syndrome (ARDS) model rats. Sixty healthy male Wistar rats were randomly divided into three groups, namely, the control group, ARDS group and ARDS + Caspase inhibitor group, with 20 rats in each group. The control group was intraperitoneally injected with 2 mL/kg saline, and the ARDS model group was established by intraperitoneally injecting 4 mg/kg Lipopolysaccharide (LPS), ARDS + Caspase inhibitor group was adminstered 20 mg/kg caspase inhibitor after intraperitoneal LPS injection. Changes in pulmonary arterial pressure (PAP) and mean arterial pressure (MAP) at 6 and 12 h before and after administration were recorded. Moreover, arterial blood gas was evaluated with a blood gas analyzer and changes in the partial pressure of O2 (PaO2), partial pressure of CO2 (PaCO2), partial pressure of O2/fraction of inspired O2 (PaO2/FiO2) were evaluated. In addition, the lung wet/dry weight (W/D) ratio and inflammatory factor levels in lung tissue were determined. Finally, pathological sections were used to determine the pulmonary artery media thickness (MT), MT percentage (MT%), and the degree of muscle vascularization. The pulmonary arterial pressure of rats was determined at several time points. Compared with the control group, the model group had a significantly increased pulmonary arterial pressure at each time point (P < 0.01), and the mean arterial pressure significantly increased at 6 h (P < 0.05). Compared with that of rats in the model group, the pulmonary arterial pressure of rats in drug administration group was significantly reduced at each time point after administration (P < 0.01), and the mean arterial pressure was significantly reduced at 6 h (P < 0.05). The arterial blood gas analysis showed that compared with those in the control group, PaO2, PaCO2 and PaO2/FiO2 in the model group were significantly reduced (P < 0.01), and PaO2, PaCO2 and PaO2/FiO2 were significantly increased after caspase inhibitor treatment (P < 0.05 or 0.01). The levels of the inflammatory mediators tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6) in the model group were significantly higher than those in the control group (P < 0.01), and they were significantly decreased after caspase inhibitor treatment (P < 0.01). In the model group, pulmonary artery MT, MT% and the degree of muscle vascularization were significantly increased (P < 0.05 or 0.01), and pulmonary artery MT and the degree of muscle vascularization were significantly reduced after caspase inhibitor treatment (P < 0.05 or 0.01). Apoptosis Repressor with a Caspase Recuitment Domain (ARC) can alleviate the occurrence and development of pulmonary hypertension (PH) by affecting hemodynamics and reducing inflammation.
Association between the serum uric acid/serum creatinine ratio and cognitive function in older adults: NHANES in the United States
Authors: Chen Gang , Tong Ling , Ye Qing
Published: July 2024

Cognitive impairment can potentially become a significant health concern in older adults. However, early effective diagnostic methods are still lacking. Therefore, we utilized the NHANES database in the US to investigate the relationship between serum uric acid to serum creatinine (SUA/SCR) ratio and cognitive impairment. In our study, a total of 3874 participants were included (2001–2002, 2011–2014). Weighted t tests or chi-square tests were utilized to analyze the basic characteristics of the population. Weighted logistic regression analysis, smooth-fit curves, threshold effects, and subgroup analysis were conducted to investigate the correlation between the SUA/SCR and cognitive impairment. In this study, the SUA/SCR was significantly lower in individuals with cognitive impairment. The logistic regression model, after adjusting for all covariates, revealed that the Q2–Q4 were 0.65 (95% CI 0.49, 0.86), 0.60 (95% CI 0.40, 0.90), 0.55 (95% CI 0.39, 0.77) respectively. This indicates that participants in the Q4 had a 45% reduced risk of cognitive impairment. Smooth-fit curves and threshold effect analysis revealed a nonlinear relationship between SUA/SCR and cognitive impairment, with a turning point at 4.13. Subgroup analysis showed no statistically significant differences in the relationship between SUA/SCR and cognitive impairment among different subgroups (P > 0.05). Our findings indicate a negative correlation between the SUA/SCR and the risk of cognitive impairment in the population of adults aged 60 and above in the US. This suggests that the SUA/SCR holds promise as a potential indicator for cognitive impairment.
Targeting neuronal epigenomes for brain rejuvenation
Authors: Zocher Sara
Published: July 2024

Aging is associated with a progressive decline of brain function, and the underlying causes and possible interventions to prevent this cognitive decline have been the focus of intense investigation. The maintenance of neuronal function over the lifespan requires proper epigenetic regulation, and accumulating evidence suggests that the deterioration of the neuronal epigenetic landscape contributes to brain dysfunction during aging. Epigenetic aging of neurons may, however, be malleable. Recent reports have shown age-related epigenetic changes in neurons to be reversible and targetable by rejuvenation strategies that can restore brain function during aging. This review discusses the current evidence that identifies neuronal epigenetic aging as a driver of cognitive decline and a promising target of brain rejuvenation strategies, and it highlights potential approaches for the specific manipulation of the aging neuronal epigenome to restore a youthful epigenetic state in the brain.
Structural insights into the molecular effects of the anthelmintics monepantel and betaine on the Caenorhabditis elegans acetylcholine receptor ACR-23
Authors: Liu Fenglian , Li Tianyu , Gong Huihui , Tian Fei , Bai Yan , Wang Haowei , Yang Chonglin , Li Yang , Guo Fei , Liu Sheng , Chen Qingfeng
Published: July 2024

Anthelmintics are drugs used for controlling pathogenic helminths in animals and plants. The natural compound betaine and the recently developed synthetic compound monepantel are both anthelmintics that target the acetylcholine receptor ACR-23 and its homologs in nematodes. Here, we present cryo-electron microscopy structures of ACR-23 in apo, betaine-bound, and betaine- and monepantel-bound states. We show that ACR-23 forms a homo-pentameric channel, similar to some other pentameric ligand-gated ion channels (pLGICs). While betaine molecules are bound to the classical neurotransmitter sites in the inter-subunit interfaces in the extracellular domain, monepantel molecules are bound to allosteric sites formed in the inter-subunit interfaces in the transmembrane domain of the receptor. Although the pore remains closed in betaine-bound state, monepantel binding results in an open channel by wedging into the cleft between the transmembrane domains of two neighboring subunits, which causes dilation of the ion conduction pore. By combining structural analyses with site-directed mutagenesis, electrophysiology and in vivo locomotion assays, we provide insights into the mechanism of action of the anthelmintics monepantel and betaine.
Novel immunomodulatory properties of adenosine analogs promote their antiviral activity against SARS-CoV-2
Authors: Monticone Giulia , Huang Zhi , Hewins Peter , Cook Thomasina , Mirzalieva Oygul , King Brionna , Larter Kristina , Miller-Ensminger Taylor , Sanchez-Pino Maria D , Foster Timothy P , Nichols Olga V , Ramsay Alistair J , Majumder Samarpan , Wyczechowska Dorota , Tauzier Darlene , Gravois Elizabeth , Crabtree Judy S , Garai Jone , Li Li , Zabaleta Jovanny , Barbier Mallory T , Del Valle Luis , Jurado Kellie A , Miele Lucio
Published: July 2024

The COVID-19 pandemic reminded us of the urgent need for new antivirals to control emerging infectious diseases and potential future pandemics. Immunotherapy has revolutionized oncology and could complement the use of antivirals, but its application to infectious diseases remains largely unexplored. Nucleoside analogs are a class of agents widely used as antiviral and anti-neoplastic drugs. Their antiviral activity is generally based on interference with viral nucleic acid replication or transcription. Based on our previous work and computer modeling, we hypothesize that antiviral adenosine analogs, like remdesivir, have previously unrecognized immunomodulatory properties which contribute to their therapeutic activity. In the case of remdesivir, we here show that these properties are due to its metabolite, GS-441524, acting as an Adenosine A2A Receptor antagonist. Our findings support a new rationale for the design of next-generation antiviral agents with dual - immunomodulatory and intrinsic - antiviral properties. These compounds could represent game-changing therapies to control emerging viral diseases and future pandemics.
Microbe-material hybrids for therapeutic applications
Authors: Chen Meng , Xia Lili , Wu Chenyao , Wang Zeyu , Ding Li , Xie Yujie , Feng Wei , Chen Yu
Published: July 2024

Microorganisms can create microbe-material hybrids for biomedical uses like bioimaging, anti-tumor, antibacterial, and anti-inflammatory treatments. These hybrids hold promise for the development of next-gen nanomedicine and biomaterials.
High magnetization composite magnetic fluid: structure, magnetorheology and new sealing mechanism in rotating seals
Authors: Susan-Resiga Daniela , Socoliuc Vlad-Mircea , Borbáth István , Borbáth Tünde , Tripon Septimiu Casian , Bălănean Florica , Vékás Ladislau
Published: July 2024

Magnetically separated Fe nanoparticles cake, with ten times higher saturation magnetization than the ferrofluid carrier, act as the main plug in the sealing stage. The burst pressure sharply increases in the concentration range where the cake fills the seal gap.
Ultrasensitive detection of the H5N1 nucleic acid fragment by ICP-MS using DNA dendrimer-carried silver nanoparticle labeling
Authors: Huang Chao , Jiao Yanni , Shao Lijun , Li Wei , Ding Shengyong , Jiang Dafeng , Jiang Wei
Published: July 2024

Ultrasensitive detection of the H5N1 nucleic acid fragment by ICP-MS using DNA dendrimer-carried AgNP labeling was developed. This approach enabled significant signal amplification, while magnetic separation effectively suppressed background signals.
Synthesis and biological evaluation of vioprolide B and its dehydrobutyrine-glycine analogue
Authors: Osorio Reineke Noé , Elsen Franziska A. V. , Grab Hanusch A. , Mostert Dietrich , Sieber Stephan A. , Bach Thorsten
Published: July 2024

Vioprolide B and an analogue, in which the (E)-dehydrobutyrine was replaced by glycine, were synthesized and studied in biological assays which revealed cytotoxicity solely for vioprolide B, presumably by covalent binding to the target protein.
Specific interaction between the DSPHTELP peptide and various functional groups
Authors: Kwon Haeun , Jin Seongeon , Ko Jina , Ryu Jungki , Ryu Ja-Hyoung , Lee Dong Woog
Published: July 2024

The specific interaction of an 8-mer peptide from the coat protein (pVIII) of the DSPH M13 bacteriophage was investigated.
Distribution characteristics of soil microplastics and their impact on soil physicochemical properties in agricultural areas of the North China plain
Authors: Zhou Yuze , Dou Ming , Zhang Yan , Ning Kaizi , Li Yuxuan
Published: July 2024

A novel image recognition method based on fluorescence staining was proposed for the batch analysis of microplastics (MPs), and the impact of MPs on soil physicochemical properties was analyzed and evaluated.
A novel method for extracting potassium (K) from K-poor and sodium-rich samples for high-precision stable K isotope analysis
Authors: Zheng Xin-Yuan
Published: July 2024

A novel method for extracting small quantities of potassium (K) from highly sodium- and calcium-rich samples for high-precision stable K isotope analysis.
One-step hydrothermal synthesis of MIL-88A/BiOCl0.1Br0.9(M88/BCB) solid solution Z-scheme heterojunction photocatalysts
Authors: Gao Yanhua , Liu Hongya , Zhang Dongfeng , Chen Ying , Liang Yuning , Ren Juan
Published: July 2024

Description of the synthesis process of a M88/BCB-scheme heterojunction.
A mild synthetic route to α-nitroso diaryl pyrroles
Authors: Brown Emily B. , Gapare Rosinah Liandrah , Campbell Jacob W. , Alkaş Adil , Sequeira Steve , Hilborn James W. , Greening Sarah M. , Robertson Katherine N. , Thompson Alison
Published: July 2024

A new synthetic method to access α-nitroso pyrroles is presented.
Preparative scale Achmatowicz and aza-Achmatowicz rearrangements catalyzed by Agrocybe aegerita unspecific peroxygenase
Authors: Pogrányi Balázs , Mielke Tamara , Díaz Rodríguez Alba , Cartwright Jared , Unsworth William P. , Grogan Gideon
Published: July 2024

The unspecific peroxygenase from Agrocybe aegerita has been applied to the oxidative expansion of furfuryl alcohols/amines on a preparative scale.
Visible-light induced selenocyclization of 2-ethynylanilines under ambient conditions: simple FeBr3 as a dual-functional catalyst
Authors: Huang Binbin , Tang Xinye , Yuan Jiawei , Zhang Mingyu , Luo Zhenyu , Wang Junlei , Lu Caicai
Published: July 2024

Reported herein is a visible-light induced selenocyclization of 2-ethynylanilines under ambient conditions, with simple FeBr3 as a dual-functional catalyst.
Xylose-derived thionocarbamates as a synthetic handle towards a functional platform of sugar-based polymers
Authors: Runge James R. , Davies Bethan , Buchard Antoine
Published: July 2024

The derivatisation of d-xylose with potassium thiocyanate, then reactivity with alkyl bromides, is presented as a versatile synthetic handle towards functional synthetic carbohydrate polymers, including via post-polymerisation modifications.
2D pyrene-based metal–organic framework nanobelts as efficient photocatalysts for the coupling of thiols into disulfides
Authors: Zhao Xin , Zhao Yajun , He Tao , Deng Jing-Tong , Mo Zong-Wen , Liu Jiewei
Published: July 2024

2D pyrene-based metal–organic framework nanobelts for the photocatalytic coupling of thiols into disulfides.
Anisotropic electronic coupling in three-dimensional assembly of CsPbBr3 quantum dots
Authors: Enomoto Kazushi , Miranti Retno , Liu Jianjun , Okano Rinkei , Inoue Daishi , Kim DaeGwi , Pu Yong-Jin
Published: July 2024

Controlled interparticle distance in the out-of-plane direction realizes anisotropic electronic coupling in the multilayers of colloidal CsPbBr3 quantum dots.
A further focus on penetration indices of misfit van der Waals crusts
Authors: Echeverría Jorge , Alvarez Santiago
Published: July 2024

The different left-right and right-left penetrations of two van der Waals crusts, one narrow and one wide, are adequately represented by the single penetration parameter defined earlier.
How Do Quantitative Videofluoroscopy Measures Differ Between People With Amyotrophic Lateral Sclerosis and Age-Matched Healthy Adults?
Authors: Gandhi Pooja , Waito Ashley A. , Peladeau-Pigeon Melanie , Plowman Emily K. , Steele Catriona M.
Published: July 2024

Purpose:

Dysphagia is a leading cause of morbidity in people with amyotrophic lateral sclerosis (PwALS). Previous videofluoroscopic swallowing studies (VFSS) in PwALS do not account for the influence of senescence. We aimed to compare swallowing in PwALS and an age- and sex-matched control group using healthy reference data to define typical and atypical values.

Method:

We conducted retrospective analysis of VFSS data from 19 PwALS (10 male,
M
age
= 63 years, range: 47–82) compared to control data from a cohort of healthy adults. Participants swallowed 20% w/v liquid barium from thin to extremely thick consistency. Blinded duplicate VFSS analysis using the ASPEKT (Analysis of Swallowing Physiology: Events, Kinematics and Timing) method yielded descriptive statistics for 16 quantitative VFSS parameters by consistency. Mann–Whitney
U
tests were used to identify significant cohort differences. Additionally, the frequencies of atypical values (in the 25% tails of the reference distribution) were tabulated by cohort and compared using odds ratios.

Results:

PwALS showed increased frequencies of multiple swallows per bolus, incomplete laryngeal vestibule closure, and reduced hyoid speed across consistencies. By contrast, similar frequencies of atypical values for pharyngeal constriction and residue in both cohorts suggest that age-related changes may contribute to the presence of these features in PwALS.

Conclusions:

This analysis builds on previous descriptions of swallowing pathophysiology in amyotrophic lateral sclerosis (ALS) by clarifying the extent to which aging may account for some of the atypical findings seen in this patient population. Longitudinal studies are recommended to further differentiate the effects of ALS from age-related changes in swallowing over the course of disease progression.
Technology of organization and comprehensive assessment of sports activities of judoka students
Authors: Kadirov Rashid Xamidovich , Azimov Laziz Axrorovich
Published: July 2024

The article deals with the organization of extracurricular activities of students studying in various educational areas of the university through classes in judo circles, general and special training, the development of aspects of competitive activity and integrated assessment technologies. On the basis of the university, was formed a group of judo and 20 students, differing in levels of mutual training and weight categories, and the circle’s classes are based on such feedback principles as current and final control, general and special physical training, individualization of the content of judo classes depending on age and level of training and sports qualifications. simultaneous increase in sports activity. According to the results of an experimental test of the effectiveness of specially organized university group classes in the 2023-24 academic year, it was found that the effectiveness of the training methodology has sufficient validity with a significant difference in the results of judo students at the beginning and at the end of the academic semester p < 0. 001 (significance level 99%). The priority of the competitive method as one of the conditions for increasing the motivation of students to study in judo circles, as well as an experimentally based technology for a comprehensive assessment of general sports activities by planning means of general physical, special physical and pre-competitive training, allowing to develop aspects of sports training.
Effective velosity coefficient as a criterion for assessing the tactical, technical and functional conditions of proffecional swimmers
Authors: Drozhetskiy D. A. , Rumyantseva E. R.
Published: July 2024

In this article, we have to test the Effective Velocity Coefficient (EVC), which we proposed as a criterion for assessing the tactical model of pacing a competitive distance by professional swimmers. The value of the coefficient itself, as well as the analysis of combinations of EVC within the distance parts of swimming (DV1-DV6) in a distance of 100 m with all styles in a 50 m swimming pools, allows to trace the distribution of energy within the distance and identify tactical and technical mistakes of swimming. The information obtained during the analysis of the competition distance demonstrates the level of functional training, indicates the biomechanical characteristics of the swimmer, and also gives an idea of the level of tactical skill. Using this type of analysis will help coaches make the training process more efficient.
Formation of healthy lifestyle as a tool to prevent psychoactive substance use and HIV infection in the Kyrgyz Republic
Authors: Bakirova Jyldyz Kadyrkulovna , Shayloobek Kyzy Aysuluu , Asekova Jyldyz Duishebaevna , Omurova Zharkyn Namirovna
Published: July 2024

The article substantiates the need for further development of the program of formation of a healthy lifestyle among young people of the Kyrgyz Republic. It is the basis of the general health of the society. The purpose of this work is to understand the process of formation of healthy lifestyle (HL) as a tool for primary prevention of substance use and HIV infection in the Kyrgyz Republic. The main objective of the work was to analyze legal and regulatory acts and programs on healthy lifestyle formation among the population, review the most important international recommendations in the field of psychoactive substances (PAS) use and HIV/AIDS prevention, and study evidence-based interventions and strategies conducted in the Kyrgyz Republic. The researchers found that with joint activities and appropriate contribution of all participants involved in the process of formation of a healthy lifestyle of young people, it is possible to realize preventive education in the field of substance use and HIV infection, as well as timely detection and quality provision of medical, social and psychological assistance.
Primary health care as a key component of the Global Public Health architecture
Authors: Sadyrbekov Kubatbek K.
Published: July 2024

Modern challenges associated with a sharp increase in morbidity and mortality in the world (non-communicable diseases, COVID-19, etc.), predetermine the improvement of public health systems and the strengthening of international cooperation in the field of medicine. The purpose of the study was to study health indicators of the population and the potential of PHC in Bishkek. Studies have shown that the PHC reforms carried out in Bishkek have not achieved their goals and have led to a deterioration in the quality and accessibility of medical care. Based on the conclusions, it is recommended to conduct point-based comprehensive scientific research of primary health care in Bishkek with a strategic analysis of the results obtained for the development of programs to improve the quality and accessibility of medical services, taking into account benchmarking international experience in the development and implementation of effective models of primary health care.
Psychological and pedagogical problems of personal self-understanding in Kyrgyz society
Authors: Myrzabek Kamchybek , Shakeeva Chinara
Published: July 2024

This article presents the results of the study, which from a new perspective are important for revealing the problem of self-understanding of the individual. Through empirical and experimental data, it is confirmed that living in the ethno-cultural conditions of a young sovereign state, on the one hand, has a similar effect on the development of self-understanding of personal and social identity both among representatives of the titular ethnic group of Kyrgyzstan and other large ethnic groups living in modern Kyrgyzstan, and so, I am an Ideal and positive attitude In relation to other people's groups, they play a central role in the formation of Self-Identity. On the other hand, it is important to take into account the issues of xenophobia, xenophilia, and control of beliefs when developing self-understanding of personal and social identity of representatives of other people’s living in Kyrgyzstan. Without finding a balance between the Ideal Self and the Real Self, xenophobia and xenophilia, the process of becoming a balanced Self-Identity can be extremely difficult for representatives of other people’s living in Kyrgyzstan, which will inevitably lead to ethnic conflicts, clashes on national grounds.
Improving the methodology of shooting the ball in the basket using exercises in asymmetrical direction in the movement of 12-14-year-old basketball players
Authors: Farmonov Utkir Alimovich , Kadirov Shakhrukh Nematovich
Published: July 2024

The basic use of exercises of an asymmetric orientation is to improve the methods of teaching throwing the ball into the basket in motion to basketball players 12-14 years old. In basketball, increased activity during the competition period, and even the intensity of defense dramatically increase the value of gears in motion. The necessity of throwing the ball into the basket, performing attacks from different distances, the importance and improvement of methods of sports training are currently increasing even more. One way to solve this problem is to take into account the influence of functional asymmetry, which is effective in the process of shooting the ball into the basket in motion. We can see in the studies that the peculiarities of the manifestation of asymmetry as a tool in the training of basketball players have shown that its actuality. Therefore, the improvement of functional asymmetry is relevant in the process of technical training of young basketball players aged 12-14 years, taking into account the individual profile. As a result of our research, we found the use of asymmetrically oriented exercises in training sessions, and this process had a positive impact on the effectiveness of technical actions performed by a weak hand.
Recreational and health aspect of theme park activities
Authors: Ryndach Marina , Kazak Anatoliy , Selivanov Victor , Gurevskikh Olga , Dolgushina Yulia , Leonid Maksimov , Chudnovskaya Tatyana , Kryukova Anastasia
Published: July 2024

The paper examines the recreational and health aspect of theme park activities. This study substantiates the idea that theme parks in the modern tourism business should become an alternative to the prohibitive construction of hotels in resort areas and traditional recreation areas. This paper is also devoted to understanding the problem of fulfilling the ambitious goals formulated by the government of the Russian Federation to form a new domestic tourism industry by 2030. According to this project, the tourist flow should double, reaching 140 million tourists per year. By 2030, 300 thousand rooms will be built; this is approximately a third of the existing ones. However, there is an alternative solution to this problem. For the development of the tourism industry, today it is more important not to build new hotels, but to create an additional tourist flow in order to increase the occupancy and profitability of existing hotels. The most effective tool for this is the creation of year-round theme parks that can attract millions of tourists to the regions and thereby reduce the seasonality of tourism.
Ecotourism as an effective direction for a healthy lifestyle
Authors: Selivanov Victor , Kazak Anatoliy , Shulga Marina , Kruglaya Natalia , Pavlenko Irina , Bukreev Igor , Sergeeva Elena , Frolova Kristina
Published: July 2024

Ecotourism is one of the effective ways to ensure a healthy lifestyle. The paper is devoted to the study of the possibilities of developing ecotourism at the Crimean resorts in the northern Black Sea region of Russia. Today, eco-tourism is becoming increasingly popular. Every year more people are looking for outdoor recreation, away from noisy cities and all-inclusive hotels. This paper also substantiates the idea that ecotourism in Crimea is not only an opportunity to enjoy the natural beauty of the peninsula, but also to gain new emotions and impressions. Crimea is a unique region where you can visit the mountains, the sea coast, steppe plains or virgin forests. Such a variety of landscapes makes it possible to create eco-tourism programs that find their admirers. Accommodation in eco-estates is another option for those who want to relax in nature. Some of them offer truly unusual living conditions, for example, in artificial caves, where there is everything you need for a comfortable stay.
Sustainable socio-economic development model: Implementation through regional ICT potential assessment
Authors: Ziankova Inha U. , Lisichonak Alena P. , Yemialyanau Aliaksandr A. , Pozdnyakova Irina A. , Gasheva Olga V.
Published: July 2024

Purpose of the study is the theoretical substantiation of sustainable socio-economic development model with realization of human potential, and its practical implementation through the assessment of Information and Communication Technologies (ICT) potential at regional level. Novelty lies in generalization of provisions of the proposed model of sustainable socio-economic development with realization of human potential as well as substantiating of implementation of this model through relevant tools in context of digitalization. Identified following results: 1) systematized theoretical approaches to modeling sustainable human development and formation of the author's model of sustainable development with the realization of human potential; 2) assessed the potential of regions of the Republic of Belarus in the field of ICT within three areas: access, use and skills; 3) compared received positions of the regions with their positions in terms of the value of the Gross Regional Product (GRP), which allowed to conclude that level of development of ICT potential influences the economic growth of regions and state. It is proposed to build the potential of the regions of Belarus in the field of ICT, which will ensure their sustainable socio-economic development, while achieving goals set within proposed model of socio-economic sustainable development with realization of human potential.
Socio-psychological aspects of adaptation of foreign students
Authors: Ysmailova Raikan , Kalmatov Roman , Dzhumaeva Lazokatkhan
Published: July 2024

The article deals with the socio-psychological aspects of adaptation of foreign students to the conditions of the educational environment. Adaptation of students to the educational process at a university generally affects the professional training of young specialists. The current and future successes of students and the process of their professional development depend on how long the adaptation process takes place in terms of time and various conditions. In the course of this study, paying attention to the socio-psychological and pedagogical side of adaptation, we supplemented the below-mentioned complex with cultural aspects. Interest in this topic can be traced from the excessive number of literary sources that consider adaptation issues in one aspect or another. We believe, adaptation potential as a set of personal properties is largely related to subjective factors, which to a certain extent characterizes the psychological state of the individual. The conducted studies, regardless of the identified characteristics of adaptation potential, do not provide an accurate explanation of the mechanism of its formation in the process of educational activities.
Regulation of NGO activities in the field of health and physical education: Problems and prospects
Authors: Alieva Malika , Abdukakharova Takhmina , Rasulzhan kyzy Zhanyl , Tokoshov Rakhim , Makambai Maksat
Published: July 2024

This article explores the regulation of non-governmental organizations (NGOs) in the field of health and physical culture in the Kyrgyz Republic. The study analyzes the current legal norms governing NGO activities and identifies the main challenges these organizations face in this area. Special attention is given to the issues of interaction between NGOs and government bodies as well as other social partners, alongside the legal aspects of implementing innovative technologies in health and physical culture and rehabilitation. The article discusses the prospects for developing a regulatory framework aimed at improving the working conditions of NGOs and provides recommendations for enhancing legislation to ensure the effective functioning of NGOs in the health and physical culture
Effect of L-arginine on myocardial vascular atherosclerosis in rabbits under high mountain environment
Authors: Akynbekova Nuriza Bolotovna , Makhmudova Zhyldyz Akmatovna , Taalaibekova Meerim Taalaibekovna , Baatyrova Nuraiym Zhumabekovna , Bekturganova Asel Orumbekovna , Niiazalieva Dzhamiila Karybekovna
Published: July 2024

The study assessed blood lipid metabolism indicators and myocardial vascular morphology in rabbits with atherosclerosis under long-term adaptation under high mountain environment against the background of L-arginine therapy and prophylaxis. The experiment was conducted on 30 rabbits divided into 5 groups. Using biochemical analyzers, changes in the concentrations of total cholesterol, triglycerides, low- and high-density lipoproteins were determined before and after atherosclerosis simulation; additionally, the effect of L-arginine on the dynamics of the lipid spectrum indicators under long-term adaptation to high mountain environment was assessed. The results were processed using SPSS 16.0 at a statistical significance level of p <0.05. Administration of L-arginine in rabbits with high cholesterol rate under long-term adaptation under high mountain environment resulted in a significant decrease in its content related to the initial increased level. Triglyceride level decreased after L-arginine therapy under adaptation to high mountain environment; however, an increase in the level of this lipid type was observed in animals receiving cholesterol simultaneously with L-arginine (prophylaxis). The therapy and prophylaxis with L-arginine resulted in a decrease in LDL level in animals with atherosclerosis under long-term adaptation to high mountain environment that may indicate the potential efficacy of the drug in the treatment of this condition.
Foundations and principles of strategic planning in the field of health care in primary care
Authors: Boltaeva Klara Shamuratovna , Kuliyev Ozodjon Abdurakhmanovich , Mustanov Tollibay Boltaevich , Mukhamedova Matlyuba Satvaldiyevna , Avilova Klara Xudjayarovna
Published: July 2024

The article examines the effectiveness of strategic planning in primary healthcare. The results show improved availability and quality of services, optimization of resources, and development of personnel qualifications. Technology integration, prevention programs, and employee engagement are also evaluated. The importance of continuously updating strategy in the context of a changing environment is emphasized for future sustainability. This article supports the need for innovation and adaptation in healthcare.
Sustainable Logistics Management of Public Procurement of Medical Equipment
Authors: Kazakov Avaz , Musaeva Nuriza , Goncharova Irina , Mambetkulova Asel , Orozonova Azyk , Akylbekova Nelli
Published: July 2024

The relevance of the study is determined by the fact that the increasingly dynamic and competitive nature of the market requires companies to provide high quality logistics services, especially in the field of medical equipment. The purpose of the study is to analyze and identify key factors influencing the efficiency of medical equipment logistics. Among the methods used were analytical method, statistical method, functional method, system analysis method, deductive method, synthesis method and comparative method. During the research, the logistics system was analyzed. The study summarizes current trends and provides practical recommendations. The practical significance of the results is to improve logistics processes and improve the quality of services.
Adaptation and Formation of a Healthy Lifestyle of Convicts after Their Release in the Context of Sustainable Socio-Economic Development
Authors: Isamatov Ernis , Dmitrienko Irina , Kochkarova Eristina , Ismailbekov Muskay , Kazakbaev Medetbek , Atakulova Aida
Published: July 2024

The article raises the legal, organizational and practical problems of the activities of penitentiary institutions to prepare prisoners for release, their social adaptation and the formation of a healthy lifestyle in the steadily developing socio-economic environment of the Kyrgyz Republic. The main target groups of people in need of social rehabilitation and adaptation have been identified. The main factors that determine the insufficient level of social adaptation of persons who have served their sentence in the form of deprivation of liberty have been established. In order to create conditions for the social rehabilitation and adaptation of persons released from places of deprivation of liberty in the territory of the Kyrgyz Republic, as well as to reduce the factors contributing to recidivism, a comprehensive programme of rehabilitation and social adaptation has been developed. The article also discusses the organizational and managerial mechanism of work to provide the necessary advisory assistance to persons who have served their sentences in prisons.
Dynamique du peuplement phytoplanctonique le long de l’axe côtier Casablanca – El Jadida
Authors: Tahraoui Soumia , Ennaffah Btissam , Morton Steve L. , Souilmi Fatima , Chaira Karima , Sagou Requia , Reani Abdeltif , Sabour Brahim
Published: July 2024

Notre étude taxonomique entre mars 2014 et novembre 2015 le long de la côte atlantique entre Casablanca et El Jadida a permis de déceler une flore phytoplanctonique représentée par les Diatomées, Dinoflagellés, Silicoflagellés et Euglenophycées avec une nette dominance des Diatomées et des Dinoflagellés. Au total, 101 taxons d’algues planctoniques ont été identifiés, témoignant d’une taxocénose relativement diversifiée. Dans cet ensemble, les Diatomées sont représentées par 62 taxons (61,4 %), les Dinoflagellés par 36 taxa (35,6 %) et les deux autres groupes (Silicoflagellés et Euglénophycées) ne sont représentés que par 3 espèces seulement (3,0 %). En ce qui concerne les espèces potentiellement toxiques, plus d’une quinzaine de taxons ont été identifiés dont la plupart sont des Dinoflagellés et des Diatomées (Pseudo-nitzschia australis et Pseudo-nitzschia cuspidata). L’analyse de l’évolution spatiotemporelle des indices de diversité (H’) et d’équitabilité (E) révèle des fluctuations saisonnières prononcées sans montrer, pour autant, une grande analogie entre les différents sites prospectés. Par ailleurs, les densités phytoplanctoniques totales présentent de grandes variations à la fois spatiales et temporelles (sur les deux cycles annuels). La présence de proliférations massives de certaines espèces potentiellement toxiques (Pseudo-nitzschia australis et Pseudo-nitzschia cuspidata, Lingulodinium polyedrum, Karenia mikimotoi), d’une nouvelle espèce de Dinoflagellé ectoparasite pour le Maroc (Amyloodinium ocellatum) et d’autres espèces opportunistes (Eutreptiella, Thalassiosira, Prorocentrum scutellum) a été notée au cours de cette étude. La détection des espèces potentiellement toxiques, parfois à des concentrations alarmantes, devrait inciter les autorités compétentes à élargir le spectre et la fréquence de biosurveillance aux sites non contrôlés.
IL-17A et IL-17F : de la découverte au ciblage thérapeutique - Un exemple de médecine translationnelle
Authors: Robert Marie , Miossec Pierre
Published: July 2024

L’interleukine (IL)-17A puis l’IL-17F ont été découvertes tour à tour pour leur rôle joué dans les maladies inflammatoires chroniques. Elles ont une homologie de séquence d’environ 50 % et partagent le même récepteur formé des chaînes IL-17RA et IL-17RC. Si elles ont des effets pro-inflammatoires assez similaires, il existe néanmoins quelques différences selon le type cellulaire considéré et selon la présence ou non de TNF, autre cytokine avec laquelle elles ont une synergie d’action. La troisième variable venant moduler leurs effets réside dans les interactions entre cellules immunes et cellules stromales, qui, là encore, varient selon le type de cellules stromales. La mise en évidence de leur rôle dans le psoriasis a notamment conduit au développement d’inhibiteurs de l’IL-17A, puis à la fois de l’IL-17A et de l’IL-17F et enfin d’un de leurs récepteurs. Ces inhibiteurs sont utilisés avec succès dans cette pathologie, et leur indication a été étendue progressivement au rhumatisme psoriasique et à certaines formes de spondylarthrite. Enfin, la récente compréhension de l’importance des cellules stromales dans la réaction inflammatoire chronique permet d’expliquer l’efficacité variable de ces biothérapies dans certaines pathologies.
Imagerie de la cavité pleurale
Authors: Gallois Bride Hélène
Published: July 2024

L’imagerie médicale est un examen complémentaire prépondérant pour explorer les affections de la cavité pleurale. Au chevet de l’animal, la radiographie et l’échographie permettent le plus souvent de faire un état des lieux complet, particulièrement lors d’épanchement pleural : détection du liquide, quantité, type d’épanchement, cause. Le pneumothorax est également une affection facile à reconnaître par radiographie.

Le scanner est réservé à l’exploration des pneumothorax spontanés et des épanchements actifs (inflammatoires/infectieux, néoplasiques) dont la cause n’a pas été élucidée par échographie.
Les infections à Anaplasma phagocytophilum et Anaplasma platys
chez les carnivores domestiques
Authors: Deshuillers Pierre , Lagrée Anne-Claire , Rouxel Clotilde , Haddad Nadia , Boulouis Henri-Jean
Published: July 2024

Les chiens et les chats sont susceptibles d’être infectés par deux rickettsiales, Anaplasma phagocytophilum et Anaplasma platys. Ces deux bactéries intracellulaires strictes sont transmises par des tiques dures, A. phagocytophilum par Ixodes spp. et A. platys par Rhipicephalus sangineus. Leurs réservoirs sont encore mal identifiés. Ces deux espèces sont susceptibles d’infecter l’homme. Cependant, les cas d’infection humaines par A. platys, sont extrêmement rares.

Outre les porteurs sains identifiés pour ces deux bactéries, elles sont à l‘origine de manifestations peu caractéristiques liées d’une part, à l’inflammation qu’elles induisent et d’autre part, aux cellules qu’elles infectent.

Elles sont dominées par des troubles généraux comme la fièvre et l’inappétence. Des manifestations liées à des atteintes localisées sont beaucoup moins fréquentes.

Le diagnostic est fondé sur la présence de morulas (micro-colonies intra-vacuolaires) mises en évidence par coloration dans les cellules infectées : granulocytes neutrophiles pour A. phagocytophilum et plaquettes pour A. platys. La PCR est aussi utilisée. La sérologie est moins indicative d’une infection en cours.

Dans les deux tests, la période pendant laquelle le résultat du test est positif est courte (une dizaine de jours) ce qui explique la fréquence des résultats faussement négatifs. Il n‘existe pas de vaccins contre ces deux espèces. La prévention est essentiellement fondée sur les moyens de lutte contre les tiques.
Isocyanoalkene Addition–Cyclization–Decarboxylation Cascades
Authors: Fleming Fraser F. , Marrazzo John-Paul R. , Huynh Tish
Published: July 2024

A rare conjugate addition to isocyanoalkenes with ethyl cyanoacetate triggers an efficient addition–cyclization–decarboxylation cascade. Using finely dispersed NaOH in THF as a base and nucleophile, is critical in facilitating the proton transfers, the ester hydrolysis, and the subsequent decarboxylation. The strategy provides an efficient route to valuable nitrile-substituted 2,3-dihydro-1H-pyrroles while providing fundamental insight into conjugate additions to isocyanoalkenes.