bluuebunny/crossref_metadata_2025 huggingface dataset:
A Cytological Study of Anther and Pollen Development in Chinquapin (Castanea henryi)
Authors: Zhong Weiping , Zhu Zhoujun , Ouyang Fen , Qiu Qi , Fan Xiaoming , Yuan Deyi
Published: May 2020

The normal development of anthers and the formation of functional pollen are the prerequisites for successful pollination and fertilization. In this study, we observed dynamic changes in inflorescence and anther development in the chinquapin (Castanea henryi) using stereomicroscopy, light microscopy, and transmission electron microscopy. We found that cytokinesis during meiosis in microsporocytes was of the simultaneous type, and that the tetrads were mainly tetrahedral. Mature pollen grains contained two cells with three germ pores. The anther wall was of the basic type and composed of epidermis, endothecium, middle layers, and tapetum. Mature anthers had no middle layer and tapetum. The tapetum was of the glandular type. At the early microspore stage, a large number of starch granules appeared in the endothecium, which was deformed at the late microspore stage. Lipid droplets appeared in tapetum during the early microspore stage, and a few lipid droplets were still found during tapetum degeneration. The mature pollen accumulated a large amount of starch and lipids. These findings demonstrated that the anther wall provides nutrients and protection for pollen development. There is relatively stable correspondence between the external morphological characteristics of male flowers and internal structure of anther development.
Аrmen А. Bunyatyan
Authors: Yavorovskiy A. G. , Vyzhigina M. A. , Zaytsev A. Yu. , Polushin Yu. S.
Published: May 2020

The article tells about Armen A. Bunyatyan, the outstanding Soviet and Russian scientist, anesthesiologist, Doctor of Medical Sciences, Professor, Academician of the Russian Academy of Sciences (September 30, 1930 – February 19, 2020). It presents his background and reflects his contribution to the development of the specialty and science of anesthesiology and resuscitation.
The Development of Teachers’ Knowledge of the Nature of Mathematical Modeling Scale
Authors: ASEMPAPA Reuben
Published: May 2020

This study addresses a gap in the literature on mathematical modeling education by developing the mathematical modeling knowledge scale (MMKS). The MMKS is a quantitative tool created to assess teachers’ knowledge of the nature of mathematical modeling. Quantitative instruments to measure modeling knowledge is scare in the literature partially due to the lack of appropriate instruments developed to assess such knowledge among teachers. The MMKS was developed and validated with a total sample of 364 K–12 teachers from several public-schools using three phases. Phase 1 addresses content validity of the scale using reviews from experts and interviews with knowledgable teachers. Initial psychometric properties and piloting results are presented in phase 2 of the study, and phase 3 reports on the findings during the field test, factor structure, and factor analyses. The results of the factor analyses and other psychometric measures supported a 12-item, one-factor scale for assessing teachers’ knowledge of the nature of mathematical modeling. The reliability of the MMKS was moderately high and acceptable (α = .84). The findings suggest the MMKS is a reliable, valid, and useful tool to measure teachers’ knowledge of the nature of mathematical modeling. Potential uses and applications of the MMKS by researchers and educators are discussed, and implications for further research are provided.
Obesity and its role in the development of metabolic syndrome in children
Authors: Panasenko L. M. , Nefedova J. V. , Kartseva T. V. , Cherepanova M. I.
Published: May 2020

The health basis and correct lifestyle habits, including proper nutrition, are formed in the childhood and adolescence. An excess or deficiency of certain nutrients can cause chronic forms of alimentary-dependent pathology. Childhood obesity results in both short-term and long-term unfavorable effects on physical and psychosocial health. The article presents modern ideas about the pathogenesis of the metabolic syndrome in children and adolescents, diagnostic, prevention and treatment methods.
Establishment and simulation of dynamic model of backfilling hydraulic support with six pillars
Authors: Tian Zhen , Jing Shuangxi , Gao Shan , Zhang Jianjun
Published: May 2020

A backfilling hydraulic support with six pillars used for working face roof support and goaf backfilling in coal mine is designed, and the structure and working principle of the backfilling hydraulic support are described. In order to improve the working stability of backfilling hydraulic support, the differential equations of motion and the state space model of backfilling hydraulic support are established based on Lagrange method and space coordinate system. According to the support structure and related parameters, the differential equation of motion of the system is solved by MATLAB. The influence law of disturbance frequency and amplitude on the top beam vertical vibration, roll and pitch vibration is obtained. The results show that the vertical vibration and roll vibration of the top beam are more severe in the low frequency range. And the degree of vibration gradually decreases as the disturbance frequency increases. As the disturbance amplitude increases, the vibration of the top beam is more severe. The vibration of the backfilling hydraulic support and the deformation distribution nephogram of the top beam are obtained by the finite element analysis, the validity of the dynamic model is verified by finite element simulation. The results provide the basis for the optimization design and the stability evaluation of backfilling hydraulic support.
Stress analysis of rotating functionally graded polar orthotropic disk under thermomechanical loading
Authors: Jalali Mohammad Hadi , Jalali Mohammad Reza
Published: May 2020

In this paper, thermo-elastic stress analysis of rotating variable thickness annular disk made of polar orthotropic functionally graded material (FGM) is presented. Elasticity modulus, density and thick-ness of the disk are assumed to vary radially according to a power law function. The material of the disk is assumed to be temperature dependent and different temperature distributions are assumed for variation of the temperature in radial direction. Radial stress and radial deformation of the disk with Clamped- Free (C-F) and Free-Free (F-F) boundary conditions are obtained using the numerical finite difference (FD) method. It is concluded that, by increasing the temperature variation, the radial stress and displacement increase. It is also observed that the radial stress in the rotating FG disk is more than the radial stress in rotating homogeneous disk and by increasing the FG index, the location of maximum stress in the disk shifts toward the outer surface. Also, the effects of temperature variation along the radius and orthotropy of the material on the radial stress and deformation are evaluated and concluded that their effect are significant. The results are compared with the available results in the literature and the good agreement between the present results and results in the literature shows the accuracy of FD method in thermo-elastic analysis of rotating FG orthotropic disk of variable thickness.
Particle stratification of a vibrating screen with translation-swing composite motion
Authors: Shen Guolang , Tong Xin
Published: May 2020

With the development of science and technology, more and more demand was proposed in the sieving industry. The sieving theory has been used to optimize parameters of vibrating screen to achieve a higher screening efficiency. Perfecting the sieving theory was became the main goal of most scholars to study the vibrating screen. Stratification as part of sieving theory research, the screening process and screening result was deeply influenced by stratification. In this paper, the sedimentation difference was defined to make the stratification became a numerical description. The discrete element method (DEM) has been used to simulate the screening process about the vibrating screen with translation-swing composite motion. The relationship between screening efficiency and sedimentation difference under each parameter is established and the effect of stratification on screening efficiency is studied under various single parameter conditions including vibration frequency, amplitude, vibration direction angle, swinging frequency, and swinging angle. The conclusions are: sedimentation difference is closely related to screening efficiency, the screening efficiency had obviously a positive correlation with the sedimentation difference. Combined with the value of the sedimentation difference, a better positive stratification is meaningful to the screening process and screening efficiency.
Vibration monitoring of CNC machinery using MEMS sensors
Authors: Wszołek Grzegorz , Czop Piotr , Słoniewski Jakub , Dogrusoz Halit
Published: May 2020

Industry 4.0 relies on the adoption of digital technologies to gather data in real time and to analyse it, providing useful information to the manufacturing system. In this paper, what solutions modern production plants that are aspiring towards compliance with philosophy of the Industry 4.0 have to adopt, monitor and analyse the vibration data of the manufacturing systems using existing process and tool monitoring solutions. In addition, detailed explanation of vibration level reading in order to increase the protection of the production sources (machines, devices etc.) against human errors and malfunctions in terms of Total Quality Management (TQM) and Total Productive Maintenance (TPM) with the concept’s levels TPM1(operator level) and TPM2(periodic conditional reviews etc.) will be giving with a Montronix system’s integration on a CNC milling machine. Besides, optimization and monitoring function of production process will be demonstrated with related graphs and tables with values of different scenarios.
Hybrid artificial genetic – neural network model to predict the transmission of vibration to the head during whole-body vibration training
Authors: Alshabi M. , Nawayseh N. , Bettayeb M.
Published: May 2020

In this work, Artificial Neural Network (ANN) modelling has been employed to investigate the effects of various factors on the biodynamic responses to vibration represented by the transmissibility and its phase. These factors include, height, weight, Body Mass Index (BMI), age, frequency and posture. Nine subjects stood on a vibrating plate and were exposed to vertical vibration at nine frequencies in the range 17-46 Hz while adopting four different standing postures; Bent Knee posture (BK), Locked Knee posture (LK), right foot to the Front and left foot to the Back posture (FB) and One Leg posture (OL). The accelerations of the vibrating plate and the head of the subjects were measured during the exposure to vibration in order to calculate the transmissibility between the vibrating plate and the head. Genetic Algorithm (GA) was used to choose ANN’s number of hidden layers and number of neurons in each layer to obtain the best performance for predicting the transmissibility. The GA compared the root mean square errors (RMSE) between the ANN outputs and the experimental outputs, and then choose the best results that could be achieved. The number of hidden layers and number of neurons tested in GA vary from one hidden layer to four hidden layers, and from one neuron per layer to one hundred neurons per layer. Several runs have been conducted to train and validate the ANN model. The results show that double hidden layer with 13 neurons in the first layer and 12 neurons in the second layer give the best candidate. The proposed model can be integrated with whole-body vibration machines in order to choose the suitable exposure based on the user’s characteristics.
A noise-resistant Wigner-Vile spectrum analysis method based on cyclostationarity and its application in fault diagnosis of rotating
Authors: Wang Hongchao , Du Wenliao
Published: May 2020

Rolling element bearing and gear are the most common used rotating parts in rotating machinery and they are also the fragile mechanical part. Studying the effective method of timely diagnosis of them is very necessary. The Wigner-Vile spectrum (WVS) is an effective time-frequency analysis and common used method for diagnosis of rotating machinery. However, it would not work effectively when the impulsion characteristic fault signal of rotating machinery is buried by strong background noise. To solve the above problem, the property of cyclostationarity of the rotating machinery signal is used, and the cyclic spectral density basing on second order cyclostationarity statistic is combined with the WVS, and the cyclic spectral density Wigner Vile spectrum (CSDWVS) time-frequency method is proposed in the paper. Through the analysis results of simulation and experiment, the CSDWVS method has the advantages of much more noise-resistant than traditional WVS method, and it could extract the fault feature of the vibration signal of rotating machinery buried in strong background noise. Besides, it also has better time frequency aggregation effect.
Dynamics modeling and experimental modal analysis of bolt loosening for lightning rod
Authors: Chen Guoda , Chen Yang , Chen Yijie , Ji Shiming
Published: May 2020

Lightning rods are effective to prevent lightning damage in power systems. However, under the influence of severe weather conditions, they often face failure problems, mainly manifested as tilt and fracture caused by bolt loosening which can result in significant economic losses. Therefore, it is very meaningful to detect the loosening of the lightning rod. The vibration-based method is an effective method for bolt loosening detection and is suitable for use on large lightning rods. This paper built a finite element model of the lightning rod Flange-Bolt Structure Unit (FBSU) based on the virtual material method, designed an effective acquisition test of the vibration signal under different loosening conditions of the lightning rod FBSU. The experimental results showed that it was effective to establish the dynamic model of the lightning rod FBSU by using the virtual material method. According to the measured vibration signal, the frequency response function was obtained by TIME MDOF method, and the preliminary judgment of bolt loosening can be realized. This study lays the foundation for the precise positioning and the extent of loosening detection of lightning rod bolt loosening, and also provides a guideline for the vibration test design of large bolted structures similar to lightning rods.
Analysis of vibroexciters working process of the improved efficiency for ice breaking, construction and road machines
Authors: Kim Alina , Doudkin Mikhail , Ermilov Alexandr , Kustarev Gennadiy , Sakimov Murat , Mlynczak Marek
Published: May 2020

In the drives of the working bodies of ice breaking, road, construction and other technological machines the use of asymmetric planetary vibration exciters becomes promising. Where rotation carrier axis of the inertial runner is shifted relative to the treadmill center. Vibro-exciters of this type as a result of the joint action of the centrifugal and Coriolis forces on the inertial slider provide a significant increase in the integral value of the directional driving force. The momentum is proportional to the eccentricity of the carrier and directed towards the specified displacement of the carrier axis. The article presents the original mathematical and graphical dependencies characterizing the workflow of these vibration exciters and confirming their effectiveness.
Effects of combustion parameters on antiexplosion performance: model tests and numerical simulations
Authors: Bai Mingxin , Xu Xianglian , Yang Hongxing , Xiong Meng , Zhu Wenqiang , Liu Zhaopeng , Luo Chenhu
Published: May 2020

This study presented a reference for design, analysis, and assessment of typical reinforced concrete (RC) piles subjected to a near-field non-contact explosion. In particular, the effects of radius on the dynamic response of the RC piles under such explosion conditions were investigated using the model tests. Furthermore, the damage and safety as well as the failure modes of such piles were analyzed using the numerical simulations. It was demonstrated that such explosions can cause a partial damage for the piles during the stage of shock waves, whereas for the stage of bubble actions, it can lead to a serious damage of the piles. For a certain distance, the failure of the piles was earlier than the bubble pulsation pressure caused at the end of the first pulsation cycle. Compared with the steel bar, the damage of concretes was more serious because the bonds between the steel bar and the concretes became more severe. Based on the experimental and numerical simulation results, a method to assess the damage of such piles under the explosion conditions was proposed, which could be applicable for the anti-explosion design and the safety and fault diagnosis of various industrial facilities and equipment.
An economic model of risk assessment for water projects
Authors: Nesticò Antonio , De Mare Gianluigi , Maselli Gabriella
Published: May 2020

The projects that concern water resources are characterized by the multiple risk rates – even extra–financial – that significantly affect their concrete feasibility. Although the risk assessment is decisive for expressing economic convenience judgements on these project initiatives, the decision-maker does not have precise references to determine whether the residual investment risk is acceptable. Thus, the purpose of the paper is to overcome the limit set by characterizing a model for the acceptability of project risk, also considering the plurality of environmental effects that the water projects generate on the community. The idea is to integrate the logic ‘As Low As Reasonably Practicable’ (ALARP) into the procedural schemes of Cost–Benefit Analysis (CBA). In accordance with this principle, widely applied in high-risk sectors such as those of industrial engineering, a risk is ALARP when the costs to further reduce it are disproportionate to the obtainable benefits. The application of the model to an irrigation reconversion intervention in a Municipality in the Province of Salerno (Italy) shows that the ALARP logic defines a general way of thinking and can contribute to the definition of effective forecasting protocols. In this sense, the proposed methodology becomes a useful support for environmental decision-making. (The paper is to be attributed in equal parts to the three authors.)
Innovative ex-situ biological biogas upgrading using immobilized biomethanation bioreactor (IBBR)
Authors: Baransi-Karkaby Katie , Hassanin Mahdi , Muhsein Sharihan , Massalha Nedal , Sabbah Isam
Published: May 2020

Biogas, which typically consists of about 50–70% of methane gas, is produced by anaerobic digestion of organic waste and wastewater. Biogas is considered an important energy resource with much potential; however, its application is low due to its low quality. In this regard, upgrading it to natural gas quality (above 90% methane) will broaden its application. In this research, a novel ex-situ immobilized biomethanation bioreactor (IBBR) was developed for biologically upgrading biogas by reducing CO2 to CH4 using hydrogen gas as an electron donor. The developed process is based on immobilized microorganisms within a polymeric matrix enabling the application of high recirculation to increase the hydrogen bioavailability. This generates an increase in the consumption rate of hydrogen and the production rate of methane. This process was successfully demonstrated at laboratory-scale system, where the developed process led to a production of 80–89% methane with consumption of more than 93% of the fed hydrogen. However, a lower methane content was achieved in the bench-scale system, likely as a result of lower hydrogen consumption (63–90%). To conclude, the IBBRs show promising results with a potential for simple and effective biogas upgrading.
Application of Artificial Intelligence in Pharmaceutical and Biomedical Studies
Authors: Thakur Abhimanyu , Mishra Ambika P. , Panda Bishnupriya , Rodríguez Diana C.S. , Gaurav Isha , Majhi Babita
Published: May 2020

Background:

Artificial intelligence (AI) is the way to model human intelligence to accomplish certain
tasks without much intervention of human beings. The term AI was first used in 1956 with The Logic Theorist
program, which was designed to simulate problem-solving ability of human beings. There have been a significant
amount of research works using AI in order to determine the advantages and disadvantages of its applicabication
and, future perspectives that impact different areas of society. Even the remarkable impact of AI can be transferred
to the field of healthcare with its use in pharmaceutical and biomedical studies crucial for the socioeconomic
development of the population in general within different studies, we can highlight those that have been
conducted with the objective of treating diseases, such as cancer, neurodegenerative diseases, among others. In
parallel, the long process of drug development also requires the application of AI to accelerate research in medical
care.

Methods:

This review is based on research material obtained from PubMed up to Jan 2020. The search terms
include “artificial intelligence”, “machine learning” in the context of research on pharmaceutical and biomedical
applications.

Results:

This study aimed to highlight the importance of AI in the biomedical research and also recent studies
that support the use of AI to generate tools using patient data to improve outcomes. Other studies have demonstrated
the use of AI to create prediction models to determine response to cancer treatment.

Conclusion:

The application of AI in the field of pharmaceutical and biomedical studies has been extensive,
including cancer research, for diagnosis as well as prognosis of the disease state. It has become a tool for researchers
in the management of complex data, ranging from obtaining complementary results to conventional
statistical analyses. AI increases the precision in the estimation of treatment effect in cancer patients and determines
prediction outcomes.
Role of the Phytochemical Compounds like Modulators in Gut Microbiota and Oxidative Stress
Authors: Martínez Yordan , Más Dairon , Betancur Cesar , Gebeyew Kefyalew , Adebowale Tolulope , Hussain Tarique , Lan Wensheng , Ding Xinghua
Published: May 2020

Background:

Currently, daily consumption of green herb functional food or medicinal herbs has increased as adopted by many people worldwide as a way of life or even as an alternative to the use of synthetic medicines. Phytochemicals, which are a series of compounds of relatively complex structures and restricted distribution in plants, usually perform the defensive functions for plants against insects, bacteria, fungi or other pathogenic factors. A series of studies have found their effectiveness in the treatment or prevention of systemic diseases such as autoimmune diseases, cancer, neurodegenerative diseases, Crohn's disease and so on.

Objective:

This review systematizes the literature on the mechanisms of the phytochemicals that react against unique free radicals and prevent the oxidative stress and also summarizes their role in gut microbiota inhibiting bacterial translocation and damage to the intestinal barrier and improving the intestinal membrane condition.

Conclusion:

The gut microbiota modulation and antioxidant activities of the phytochemicals shall be emphasized on the research of the active principles of the phytochemicals.
Sulfonamides: Antiviral Strategy for Neglected Tropical Disease Virus
Authors: Dash Rudra Narayan , Moharana Alok Kumar , Subudhi Bharat Bhusan
Published: May 2020

The viral infections are a threat to the health system around the globe. Although more than 60 antiviral drugs have been approved by the FDA, most of them are for the management of few viruses like HIV, Hepatitis and Influenza. There is no antiviral for many viruses including Dengue, Chikungunya and Japanese encephalitis. Many of these neglected viruses are increasingly becoming global pathogens. Lack of broad spectrum of action and the rapid rise of resistance and cross-resistance to existing antiviral have further increased the challenge of antiviral development. Sulfonamide, as a privileged scaffold, has been capitalized to develop several bioactive compounds and drugs. Accordingly, several reviews have been published in recent times on bioactive sulfonamides. However, there are not enough review reports of antiviral sulfonamides in the last five years. Sulfonamides scaffolds have received sufficient attention for the development of non- nucleoside antivirals following the emergence of cross-resistance to nucleoside inhibitors. Hybridization of bioactive pharmacophores with sulfonamides has been used as a strategy to develop sulfonamide antivirals. This review is an effort to analyze these attempts and evaluate their translational potential. Parameters including potency (IC50), toxicity (CC50) and selectivity (CC50/IC50) have been used in this report to suggest the potential of sulfonamide derivatives to progress further as antiviral. Since most of these antiviral properties are based on the in vitro results, the drug-likeness of molecules has been predicted to propose in vivo potential. The structure-activity relationship has been analyzed to encourage further optimization of antiviral properties.
Evaluating Lean Liver Volume as a Potential Scaler for In Vitro-In Vivo Extrapolation of Drug Clearance in Obesity Using the Model Drug Antipyrine
Authors: Sinha Jaydeep , Duffull Stephen B. , Green Bruce , Al-Sallami Hesham S.
Published: May 2020

Background:

In vitro-in vivo extrapolation (IVIVE) of hepatic drug clearance (CL) involves the scaling of
hepatic intrinsic clearance (CLint,uH) by functional liver size, which is approximated by total liver volume (LV) as
per the convention. However, in most overweight and obese patients, LV includes abnormal liver fat, which is not
thought to contribute to drug elimination, thus overestimating drug CL. Therefore, lean liver volume (LLV) might be
a more appropriate scaler of CLint,uH.

Objective:

The objective of this work was to assess the application of LLV in CL extrapolation in overweight and
obese patients (BMI>25 kg/m2) using a model drug antipyrine.

Methods:

Recently, a model to predict LLV from patient sex, weight, and height was developed and evaluated. In
order to assess the LLV model’s use in IVIVE, a correlation-based analysis was conducted using antipyrine as an
example drug.

Results:

In the overweight group (BMI >25 kg/m2), LLV could describe 36% of the variation in antipyrine CL
(R2 = 0.36), which was >2-fold higher than that was explained by LV (R2 = 0.17). In the normal-weight group
(BMI ≤25 kg/m2), the coefficients of determination were 58% (R2 = 0.58) and 43% (R2= 0.43) for LLV and LV,
respectively.

Conclusion:

The analysis indicates that LLV is potentially a more appropriate descriptor of functional liver size than
LV, particularly in overweight individuals. Therefore, LLV has a potential application in IVIVE of CL in obesity.
Influence of the Intestinal Microbiota on Diabetes Management
Authors: Alvarez-Vieites Eva , López-Santamarina Arora , Miranda José M. , del Carmen Mondragón Alicia , Lamas Alexandre , Cardelle-Cobas Alejandra , Nebot Carolina , Franco Carlos M. , Cepeda Alberto
Published: May 2020

In recent decades, there has been a very rapid increase in the prevalence of diabetes globally,
with serious health and economic implications. Although today there are several therapeutic treatments
for this disease, these do not address the causes of the disease and have serious side effects, so it
is necessary to seek new treatments to replace or complement the existing ones. Among these complementary
treatments, a strong link between the intestinal microbiota and diabetes has been demonstrated,
which has focused attention on the use of biotherapy to regulate the function of the intestinal microbiota
and, thus, treat diabetes. In this way, the main objective of this work is to provide a review of
the latest scientific evidence on diabetes, gathering information about new trends in its management,
and especially, the influence of the intestinal microbiota and microbiome on this pathology. It is possible
to conclude that the relationship between the intestinal microbiota and diabetes is carried out
through alterations in energy metabolism, the immune system, changes in intestinal permeability, and a
state of low-intensity systemic inflammation. Although, currently, most of the experimental work, using
probiotics for diabetes management, has been done on experimental animals, the results obtained
are promising. Thus, the modification of the microbiota through biotherapy has shown to improve the
symptoms and severity of diabetes through various mechanisms related to these alterations.
Cardio-Rheumatology: Cardiovascular Complications in Systemic Autoimmune Rheumatic Diseases / Is Inflammation the Common Link and Target?
Authors: Manolis Antonis S. , Tzioufas Athanasios G.
Published: May 2020

In the current Thematic Issue of Current Vascular Pharmacology (CVP), entitled “Systemic Autoimmune
Rheumatic Diseases and Cardiology”, presented in two parts, Part 1 and Part 2, review articles are included from specialists
in cardiology, rheumatology, immunology and related fields. These reviews discuss the cardiovascular complications
of the main systemic Autoimmune Rheumatic Diseases (ARDs). For example, the underlying pathogenetic mechanisms,
the role of cardiovascular imaging and recommendations for prevention and management. These articles place inflammation
as the key process, linking cardiovascular complications with ARDs. From all these reviews, the conclusion is the
need for collaboration between the disciplines of Rheumatology and Cardiology to establish the emerging field of Cardio-
Rheumatology. This will aid to fine-tune risk stratification and optimize preventive strategies and pharmacological therapies
for patients with ARDs.
Anxiety and Osteoarthritis Disability: Updated Overview and Commentary
Authors: Marks Ray
Published: May 2020

Introduction:

Osteoarthritis, a widespread highly painful often incapacitating joint disease continues to impose immense personal and societal challenges among adults of all ages, especially among older adults. In the absence of any effective cure or treatment, it has become essential to explore all correlates of this chronic disabling disease, especially those that might be preventable or modifiable. Anxiety, a potentially remediable state of mental distress - found linked to chronically disabling forms of arthritis, in various imperceptible ways, and which may have an immense bearing on the outcomes of osteoarthritis, has not received as much attention in the related literature as other topics, such as surgery.

Objective:

In line with previous promising work, this narrative review elected to explore the extent to which current researchers in the field are pursuing this topic, and if so, the degree to which prevailing peer-reviewed data sources support an important role for continued research in this realm, and in what regard.

Methods:

Primarily explored were the key databases housing relevant publications that emerged over Aug 1, 2018-Feb 26, 2020 using the keywordsOsteoarthritisandAnxiety.Using a descriptive approach, the relative progress made over the past five previous years in this regard was assessed, in addition to what joints have been studied and with what frequency, and how the degree of interest compares to other currently researched osteoarthritis themes. The potential for intervening in the osteoarthritis pain cycle by addressing anxiety was also examined.

Results:

Findings show a high level of current interest in this topic, and that despite the paucity of prospective studies, studies on joints other than the knee and hip joints, some equivocal conclusions, small numbers of anxiety-related studies compared to other topics, and substantive design limitations, it appears that future research in this realm is strongly indicated.

Conclusion:

This topic if examined further is likely to produce highly advantageous results at all stages of the osteoarthritic disease process and in the context of primary, secondary, as well as tertiary measures to ameliorate osteoarthritis pain and disability.
The Impact of Royal Jelly against Hepatic Ischemia/Reperfusion-Induced Hepatocyte Damage in Rats: The Role of Cytoglobin, Nrf-2/HO-1/COX-4, and P38-MAPK/NF-κB-p65/TNF-α Signaling Pathways
Authors: Ali Fares E.M. , Saad Eldien Heba M. , Mostafa Nashwa A.M. , Almaeen Abdulrahman H. , Marzouk Mohamed R.A. , Eid Khalid M. , Ghoziz Ahmed H.E. , Ebrahiem Abdelaziz F. , Hagag Mohamed G. , Ghogar Osama M.
Published: May 2020

Objective:

The present study was conducted to elucidate the underlying molecular mechanism as well as the potential hepatoprotective effects of royal jelly (RJ) against hepatic ischemia/reperfusion (IR) injury.

Methods:

Rats were assigned into four groups; sham (received vehicle), IR (30 minutes ischemia and 45 minutes reperfusion), sham
pretreated with RJ (200 mg/kg P.O.), and IR pretreated with RJ (200 mg/kg P.O.). The experiment has lasted for 28 days.

Results:

Hepatic IR significantly induced hepatic dysfunctions, as manifested by elevation of serum transaminases, ALP and LDH
levels. Moreover, hepatic IR caused a significant up-regulation of P38-MAPK, NF-κB-p65, TNF-α and MDA levels along with
marked down-regulation of Nrf-2, HO-1, COX-4, cytoglobin, IκBa, IL-10, GSH, GST and SOD levels. Additionally, marked histopathological changes were observed after hepatic IR injury. On the contrary, pretreatment with RJ significantly improved hepatic
functions along with the alleviation of histopathological changes. Moreover, RJ restored oxidant/antioxidant balance as well as hepatic expressions of Nrf-2, HO-1, COX-4, and cytoglobin. Simultaneously, RJ significantly mitigated the inflammatory response by
down-regulation of P38-MAPK, NF-κB-p65, TNF-α expression.

Conclusion:

The present results revealed that RJ has successfully protected the liver against hepatic IR injury through modulation of
cytoglobin, Nrf-2/HO-1/COX-4, and P38-MAPK/NF-κB-p65/TNF-α signaling pathways.
Tele-Rehabilitation to Combat Rehabilitation Service Disruption During COVID-19 in Hong Kong: Observational Study (Preprint)
Authors: Ku Benny Pang Shing , Tse Ada Wai Shan , Pang Benny Chu Hang , Cheung Ngai Tseung , Pang Joanna Yuk Wa , Chan Joyce Ka Yin , Hui Hing Loi , Chu Dave , Choi Kevin Hoi Wa
Published: May 2020

BACKGROUND

A tele-rehabilitation platform was developed to improve access to ambulatory rehabilitation services in Hong Kong. The development was completed in October 2019 and rolled out for use to occupational therapists, physiotherapists, and speech therapists. During the COVID-19 pandemic, rehabilitation services were severely interrupted. Tele-rehabilitation was used extensively to meet the demand for rehabilitation service delivery.

OBJECTIVE

The aims of this study were to (1) describe the design and development process of a tele-rehabilitation service, and (2) study how the tele-rehabilitation platform was used to overcome the disruption of rehabilitation service during the COVID-19 pandemic.

METHODS

Tele-rehabilitation was developed utilizing 4 core determinants of Unified Theory of Acceptance and Use of Technology as guiding principles. A generic prescription platform, called the activity-based prescription system, and a mobile app, called the Rehabilitation App, were built. Five outcomes were used to examine the utilization of tele-rehabilitation both before and during the pandemic: throughput, patient demographic, patient conditions, workforce, and satisfaction from patients and staff.

RESULTS

There was a tremendous increase in the use of tele-rehabilitation during pandemic. The total number of patients (up until July 2020) was 9101, and the main age range was between 51 to 70 years old. Tele-rehabilitation was used for a much wider scope of patient conditions than originally planned. More than 1112 therapists, which constituted 50.6% of the total workforce (1112/2196), prescribed tele-rehabilitation to their patients. Moreover, there was a high satisfaction rate from patients, with a mean rating of 4.2 out of 5, and a high adherence rate to prescribed rehabilitation activities (107840/131995, 81.7%).

CONCLUSIONS

The findings of our study suggested that tele-rehabilitation in the form of a generic prescription platform and mobile app can be an effective means to provide rehabilitation to patient. During the COVID-19 pandemic, tele-rehabilitation has been used extensively and effectively to mitigate service disruption. Our findings also provide support that there is a high level of satisfaction with tele-rehabilitation; however, a longer duration study is required to demonstrate the sustained use of tele-rehabilitation, especially after the pandemic.
Effectiveness, Acceptability, and Feasibility of Digital Health Interventions for LGBTIQ+ Young People: Systematic Review (Preprint)
Authors: Gilbey Dylan , Morgan Helen , Lin Ashleigh , Perry Yael
Published: May 2020

BACKGROUND

Young people (aged 12-25 years) with diverse sexuality, gender, or bodily characteristics, such as those who identify as lesbian, gay, bisexual, transgender, intersex, or queer (LGBTIQ+), are at substantially greater risk of a range of mental, physical, and sexual health difficulties compared with their peers. Digital health interventions have been identified as a potential way to reduce these health disparities.

OBJECTIVE

This review aims to summarize the characteristics of existing evidence-based digital health interventions for LGBTIQ+ young people and to describe the evidence for their effectiveness, acceptability, and feasibility.

METHODS

A systematic literature search was conducted using internet databases and gray literature sources, and the results were screened for inclusion. The included studies were synthesized qualitatively.

RESULTS

The search identified 38 studies of 24 unique interventions seeking to address mental, physical, or sexual health–related concerns in LGBTIQ+ young people. Substantially more evidence-based interventions existed for gay and bisexual men than for any other population group, and there were more interventions related to risk reduction of sexually transmitted infections than to any other health concern. There was some evidence for the effectiveness, feasibility, and acceptability of these interventions overall; however, the quality of evidence is often lacking.

CONCLUSIONS

There is sufficient evidence to suggest that targeted digital health interventions are an important focus for future research aimed at addressing health difficulties in LGBTIQ+ young people. Additional digital health interventions are needed for a wider range of health difficulties, particularly in terms of mental and physical health concerns, as well as more targeted interventions for same gender–attracted women, trans and gender-diverse people, and people with intersex variations.

CLINICALTRIAL

PROSPERO International Prospective Register of Systematic Reviews CRD42020128164; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=128164
Experiences of Psychotherapists With Remote Psychotherapy During the COVID-19 Pandemic: Cross-sectional Web-Based Survey Study (Preprint)
Authors: Humer Elke , Stippl Peter , Pieh Christoph , Pryss Rüdiger , Probst Thomas
Published: May 2020

BACKGROUND

The current situation around the COVID-19 pandemic and the measures necessary to fight it are creating challenges for psychotherapists, who usually treat patients face-to-face with personal contact. The pandemic is accelerating the use of remote psychotherapy (ie, psychotherapy provided via telephone or the internet). However, some psychotherapists have expressed reservations regarding remote psychotherapy. As psychotherapists are the individuals who determine the frequency of use of remote psychotherapy, the potential of enabling mental health care during the COVID-19 pandemic in line with the protective measures to fight COVID-19 can be realized only if psychotherapists are willing to use remote psychotherapy.

OBJECTIVE

This study aimed to investigate the experiences of psychotherapists with remote psychotherapy in the first weeks of the COVID-19 lockdown in Austria (between March 24 and April 1, 2020).

METHODS

Austrian psychotherapists were invited to take part in a web-based survey. The therapeutic orientations of the psychotherapists (behavioral, humanistic, psychodynamic, or systemic), their rating of the comparability of remote psychotherapy (web- or telephone-based) with face-to-face psychotherapy involving personal contact, and potential discrepancies between their actual experiences and previous expectations with remote psychotherapy were assessed. Data from 1162 psychotherapists practicing before and during the COVID-19 lockdown were analyzed.

RESULTS

Psychotherapy conducted via telephone or the internet was reported to not be totally comparable to psychotherapy with personal contact (P<.001). Psychodynamic (P=.001) and humanistic (P=.005) therapists reported a higher comparability of telephone-based psychotherapy to in-person psychotherapy than behavioral therapists. Experiences with remote therapy (both web- and telephone-based) were more positive than previously expected (P<.001). Psychodynamic therapists reported more positive experiences with telephone-based psychotherapy than expected compared to behavioral (P=.03) and systemic (P=.002) therapists. In general, web-based psychotherapy was rated more positively (regarding comparability to psychotherapy with personal contact and experiences vs expectations) than telephone-based psychotherapy (P<.001); however, psychodynamic therapists reported their previous expectations to be equal to their actual experiences for both telephone- and web-based psychotherapy.

CONCLUSIONS

Psychotherapists found their experiences with remote psychotherapy (ie, web- or telephone-based psychotherapy) to be better than expected but found that this mode was not totally comparable to face-to-face psychotherapy with personal contact. Especially, behavioral therapists were found to rate telephone-based psychotherapy less favorably than therapists with other theoretical backgrounds.
On the Lenin’s Journalistic Thought and China’s News Work in the Context of New Media
Authors: Jia Chaoran , She Jia
Published: May 2020

April 22nd, 2020 is the 150th anniversary of Lenin’s birth. As a journalist, the author, under the guidance of Socialism with Chinese characteristics, has mainly reviewed Lenin’s news thought, which has not only the commemorative significance, but the practical significance in enlightening China’s current news work. This article, taking the main content and the main principles of Lenin’s news thought as its theoretical support, has studied the enlightenment of Lenin’s news thought on China’s Journalistic work in the era of new media.
An Effective Training and Evaluation Method for Anchoring Training in Maritime Education
Authors: Kunieda Yoshiaki , Kumagai Kei , Kashima Hideyuki , Murai Koji
Published: May 2020

Captain Kashima et al. showed that ship handling skills significantly improve when anchoring exercises are practiced on training ships. And Kunieda et al. showed that the practicing on training ships also develops critical thinking and problem-solving skills. We created an evaluation scale for elementary ship handling skills to measure the effects of different anchoring training methods. We assessed the training methods using a rubric evaluation list containing nine evaluation items. Group work was arranged before and after the anchoring training sessions based on the results from student questionnaires and instructor evaluations. Our results reveal the most effective training model for developing ship handling skills.
Ensino e formação: a prática apaixonada de uma semioticista
Authors: Soares de Lima Eliane
Published: May 2020

O texto apresentado tem a intenção de fazer um breve registro de alguns pontos do percurso profissional exemplar – porque verdadeiramente empenhado no compromisso com o ensino e a formação de seus alunos no contexto da Academia – da professora Diana Luz Pessoa de Barros. Sem qualquer pretensão de contribuição científica, o objetivo é unicamente o de prestar uma justa homenagem a ela; o que explica, e justifica, a adoção de um tom bastante pessoal e exacerbadamente afetivo, típico aos discursos da admiração. De toda forma, na tentativa de apresentar um “estilo Diana de ser professora” um pouco mais objetivo, propõe-se também uma breve análise de relatos recolhidos entre seus ex-alunos e orientandos.
Una experiencia educativa transmedia
Authors: Zorrilla Abascal María Luisa
Published: May 2020

En el video, la doctora Zorrilla de la Universidad Autónoma de Morelos, en México, comenta el concepto de narrativa transmedia y presenta una investigación-intervención desarrollada en una escuela morelense donde los estudiantes abordaron una novela en tres soportes diferentes. Incluye testimonios de alumnos y comparte, a través de un sitio web, recursos adicionales sobre el tema. Video disponible: https://youtu.be/kuWU8uDUbuc
Desarrollo de recursos didácticos basados en realidad mixta en el bachillerato a distancia
Authors: Cavazos Salazar Rosario Lucero , Suárez Escalona Rubén
Published: May 2020

El crecimiento constante de la tecnología, como el caso de la creciente expansión de la industria 4.0, ha ocasionado que las universidades se interesen cada vez más en preparar a sus egresados para enfrentar los retos del mañana. Por tal motivo, el objetivo de este trabajo es compartir la experiencia en la implementación de objetos de aprendizaje basados en realidad mixta que fueron desarrollados e implementados en el bachillerato a distancia de la Universidad Autónoma de Nuevo León.El Proyecto Reto Verde es el producto de un trabajo interdisciplinario, el cual tiene como objetivos concientizar a los estudiantes sobre la importancia del cuidado del medioambiente, y, a la vez, construir una identidad de universitarios mediante objetos de aprendizaje de realidad mixta, con los que los alumnos pueden conocer el campus de la ciudad universitaria en un recorrido virtual que les permite interactuar con distintos objetos, principalmente los árboles del campus, que muestran información general sobre sus características y una reseña histórica de su presencia en el campus, cuando se pulsa sobre ellos.El diseño de este proyecto se realizó con la metodología Design Thinking y los resultados muestran que los estudiantes se sienten motivados a utilizar la realidad mixta para múltiples actividades escolares con fines educativos.
Support Vector Machine-based Modified Sp Statistic for Subset Selection with Non-Normal Error Terms
Authors: Desai Shivaji Shripati , Kashid D. N.
Published: May 2020

Support vector machine (SVM) is used for estimation of regression parameters to modify the sum of cross products (Sp). It works well for some nonnormal error distributions. The performance of existing robust methods and the modified Sp is evaluated through simulated and real data. The results show the performance of the modified Sp is good.