bluuebunny/crossref_metadata_2025 huggingface dataset:
A STUDY ON GOVERNANCE AND DEVELOPMENT IN BODOLAND TERRITORIAL AREA DISTRICTS OF ASSAM IN INDIA
Authors: Basumatary Nicodim , Panda Bhagirathi
Published: November 2019

Purpose of the study: The study examines the relationship between the quality of governance and level of development in the Bodoland Territorial Area District (BTAD) of Assam in India. It also assesses which dimensions of governance influence the level of development. Methodology: The study is based on the data collected from a field survey of 400 households in both rural and urban areas of BTAD. Important dimensions pertaining to measuring the quality of governance is a broad manifestation in several institutions such as Political, Legal and Judicial, Administration and Public service delivery, and Economic and Social. Similarly, we measure development in terms of economic, social and empowerment dimensions. The study uses statistical techniques of Correlation and CHAID analysis. Main findings: The study finds that the quality of governance is critical to development. Amongst other factors, efficient system and management of political institutions and effective administration and public service delivery is the key to enhancement of economic development. Social Implications: The study depicts disparity with respect to social and economic space; and suggests inclusive participation in political and fine-tuning in the front of administration and delivery of public services. Originality/Novelty of the study: The study brings out the dynamics of deficit of governance and its impact on economic development at the level of the sub-national state. It further confirms and substantially contributes to the literature on development – governance nexus.
Models of Data Storage Tables Connection Processes by MapReduce/Spark Technology
Authors: Proletarskaya V.А. , Grigoriev Yu.A.
Published: November 2019

A model has been developed and an estimate of the amount of data transmitted over the network has been obtained with duplicating the table across nodes and using the Bloom filter in the MapReduce/Spark environment. Models have been developed for fulfilling queries for joining database tables in the cascading Bloom filter in the same environment. Two cases of joining tables are considered: 1) several bushes with one dimension in each of them; 2) one bush with several dimensions --- star-type storage. We obtained an estimate of the Bloom filter volume transmitted over the network when the tables are joined. Using the example of the Q3 request from the TPC-H test, we analyzed the adequacy of the estimated gain in the amount of data transmitted over the network using the cascading Bloom filter. The prediction error was 2 %.
New Adaptive Multi-Memetic Global Optimization Algorithm for Loosely Coupled Systems
Authors: Sakharov M.K.
Published: November 2019

This study introduces a new parallel adaptive multi-memetic population-based algorithm for solving global optimization problems efficiently on loosely coupled computing systems. The existent approaches to the synthesis of adaptive population-based algorithms were considered along with the parallelization techniques; distinct features of the loosely coupled computing systems were identified; those features have to be considered carefully when designing algorithms for this class of systems. The proposed algorithm is based on the two level adaptation strategies. The upper level is a static one and allows one to adjust numeric values of the basic algorithm's free parameters before the optimization process using the information about an objective function obtained by means of the landscape analysis. The lower level is a dynamic one and was implemented by means of hybridization of the basic algorithm and several local search methods (memes). The work also presents a new static load balancing method for mapping the proposed algorithm onto parallel computing nodes. The proposed load balancing method takes into consideration both the optimization algorithm's distinct features and the computing system's architecture. This results in higher efficiency of the optimization algorithm comparing to the traditional load balancing methods. A wide performance investigation of the proposed optimization algorithm and its software optimization was carried out in this work with a use of high-dimensional benchmark functions of various classes.
Numerical Simulation of Non-Destructive Remote Field Eddy Current Testing of Rolled Metal Tubes
Authors: Efimov A.G. , Kuzelev N.R. , Martyanov E.V. , Kanter B.M. , Shubochkin A.E.
Published: November 2019

The first publications describing the physical principles of the non-destructive remote field eddy current testing method appeared about 30 years ago. This method allows to significantly expand the field of application of eddy current testing. However, due to the lack of a theoretical justification, this method did not get widespread use around the world. Domestic publications in this area are completely absent, and the descriptions given in few foreign publications often contradict each other. There are no results of full-scale simulation using numerical methods in available domestic and foreign sources. The distinctive feature of this method under consideration is the ability of detecting defects on the external (with respect to the eddy current transducer) side of the tested object, which is impossible for the classical eddy current method due to the limited eddy current penetration depth. The basics of the method were considered, the distinctive features were presented, and the advantages and disadvantages of remote field eddy current testing of metals were pointed out. A numerical simulation with the subsequent analysis of the obtained results has been carried out, the transducer design for remote field eddy current testing is given. The influence of various factors on the change in the added voltage of the signal coil of the eddy current transducer in the presence of a defect in the external wall of the tube was considered. Expressions that determine the optimal ratio of the diameters of the transducer and the tested product were obtained. The values of the test parameters and the limiting wall thickness of the tested ferromagnetic product were determined.
Modernization of the System for Measuring Cutting Forces on the Basis of UDM Dynamometer Series
Authors: Samoylov V.B.
Published: November 2019

The purpose of the research was to analyze the existing systems for measuring forces during machining of parts on metal-cutting machine tools, and to consider the options for using both specialized ready-made solutions and dynamometer heads of the UDM series as measuring transducers. The study shows the drawbacks of the well-known general-circuit solutions for the modernization of these dynamometers, associated with the need to use heterogeneous sets of amplifying and transforming equipment. We propose low-budget solutions to improve the accuracy and reliability of measurements, to control and record measurement results in a modern software environment using virtual instruments. As a result of the study, we implemented hardware and software methods for processing measurement information, accompanying experimental studies in real time. The universal scalable systems developed for measuring moments and cutting forces are used both during academic research work and educational process of the university The work is carried out under the program "Scientific and scientific-pedagogical personnel of innovative Russia", event: 1.2.1. Scientific studies are done by research teams under the guidance of doctors of science; the research area is "Creation and processing of composite ceramic materials", the project is "Improving the efficiency of mechanical and abrasive machining of parts made of composite ceramic materials"
Mathematical Simulation of the Behavior of a Cumulative Jet with Inert and Reactive Components
Authors: Babkin A.V. , Medeltsev A.A. , Zagryadskiy F.S. , Krutskevich M.A.
Published: November 2019

The purpose of the research was to investigate the processes associated with the free flight of a cumulative jet formed from a composite liner of a cumulative charge. We mathematically simulated the process from the perspective of continuum mechanics using numerical methods for solving the corresponding equations. The cumulative jet was simulated in the quasi-two-dimensional nonstationary approximation as a high-gradient cylindrical compressible elastoplastic or liquid rod. The material of the jet was considered as a one-speed three-phase medium. The compressibility of each phase was described by its inherent barotropic dependence of pressure on density. The resulting pressure in a multiphase mixture of particles of the cumulative jet, considered as a composite material, was determined on the basis of the additivity condition of the volumes. When assessing the composition of the jet, we determined the initial concentrations of the components using a software package for thermo-dynamic simulation of chemically reacting systems. To find the numerical solution of the multi-phase, i.e., composite, jet extension problem, we used a finite-difference method based on Neumann --- Richtmyer scheme. The numerical analysis of the process under study was carried out on the example of a laboratory cumulative charge. Within the research, we found the characteristic features and possible variations in the behavior of the jet depending on the presence of the components of the composite liner, i.e., matrix, inert and reactive additives, and their properties. Finally, we estimated the change in the penetrating power of the jet compared to the reference variant of the cumulative liner of a homogeneous single-phase monolithic material.
Heat Transfer with Absorption in Anisotropic Thermal Protection of High-Temperature Products
Authors: Formalev V.F. , Kolesnik S.A. , Garibyan B.A.
Published: November 2019

The purpose of the research was to study the non-stationary heat transfer in anisotropic thermal protection under the action of unsteady heat flows distributed along the body, when there are thermal energy sinks inside the body, the energy being proportional to temperature, due to endothermic physical and chemical transformations. Thermal protection is made of anisotropic material, such as phenol-formaldehyde fiberglass, asboplastics, carbon-carbon plastics, etc. A new analytical solution has been obtained for the problem of plate heating under the action of unsteady heat flows distributed along the body. Using this solution, we studied the temperature fields when the components and orientation angles of the main axes of the thermal conductivity tensors of anisotropic heat-shielding materials were changed. Findings of research show that with increasing time, the temperature field inside the plate is localized and does not extend further than the limiting isotherm.
Simulation of the Spectra of the Transverse Kerr Effect of Magnetic Nanocomposites FeCoZr−Al2O3
Authors: Yashin M.M. , Yurasov A.N. , Ganshina E.A. , Garshin V.V. , Semenova D.V. , Mirzokulov Kh.B.
Published: November 2019

The magneto-optical properties of magnetic nanocomposites have been studied in the study of spectral dependences of the transverse Kerr effect (TKE). Experimental preparation of nanocomposites formed from FeCoZr and Al2O3 alloys at different component concentrations by ion-beam sputtering is discussed. Discuss various methods of the theoretical study of nanocomposites depending on the concentration of ferromagnetic components. The spectral dependences of TKE at low concentrations of the metal component are investigated. Spectral dependences of the Kerr transverse effect are simulated in the framework of the TKE are compared taking into account the size effect at different values of the nanocomposite granule size. There is a good qualitative and quantitative agreement between experimental and theoretical spectral dependences of TKE. In addition, in this paper, we note both practical and fundamental importance of the results. The possibilities of using such nanocomposite materials are discussed.
The Effects of Dietary Vitamin C Levels on Tissue Ascorbic Acid Concentration and Growth in European Sea Bass (Dicentrarchus labrax, L.1758)
Authors: KOP Aysun
Published: November 2019

The effect of different dietary levels of L-ascorbic acid on the growth and vitamin C concentration in the tissue of European Sea bass (Dicentrarchus labrax, L.1753) with an initial body weight of 4.6±1.1 g was studied. Four practical diets were formulated to containing 10 (AA10), 25 (AA25), 42 (AA42) and 65 (AA65) mg ascorbic acid equivalent kg-1 diet. The results of a 20 week feeding trial showed that typical vitamin C-deficiency signs and high mortality in the fish fed with the AA10 diet. The fish fed with AA42 (42 mg kg-1 AA diet) showed a significantly higher final body weight than the other diets (P less than 0.05) and the concentrations of ascorbic acid (AA) in the brain of these fish were higher than in the other experimental group (P less than 0.05). In this study, the amount of storage in the organs occurred in this order: brain, kidney, liver.
Macroanatomical Investigation of Arteria Coronaria and Myocardial Bridges in Tuj and Hemshin Sheep
Authors: Gürbüz Ýftar , Aksoy Gürsoy
Published: November 2019

In the study, it was aimed that the macroanatomic features of the coronary arteries and myocardial bridges were investigated in Tuj and Hemshin sheep. 10 hearts of male Tuj sheep and 10 hearts of male Hemshin sheep were used as the study material. It was applied the latex injection and corrosion cast techniques. It was observed that the hearts were vascularized by arteria (a.) coronaria dextra and a. coronaria sinistra. A. coronaria sinistra was dominant in 8 Tuj and 9 Hemshin sheep, a. coronaria dextra was dominant in 2 Tuj and 1 Hemshin sheep. The r. interventricularis subsinuosus was formed by ramus (r.) circumflexus sinister in 8 Tuj and 9 Hemshin sheep, by r. circumflexus dexter in 1 Tuj sheep, and by r. proximalis atrii dextri in 1 Tuj and 1 Hemshin sheep. There were myocardial bridges on the r. interventricularis paraconalis in all of the hearts. There was a statistical difference in the length of the myocardial bridges on the sulcus interventricularis paraconalis between the hearts of Tuj and Hemshin sheep (P less than 0.05).
Immunomodulatory Potential of Microencapsulated Multispecies Probiotic Consortium in Newcastle Disease Virus Vaccinated Chicken
Authors: Radhika G. , Subriya S. , Manjari K. Divya , Parthiban M. , Pazhanivel N. , Vijayarani K.
Published: November 2019

A study was conducted to investigate the effect of microencapsulated probiotic consortium containing Lactobacillus plantarum, Enterococcus faecium, Enterococcus hirae, Pediococcus acidilactici and Weissella paramesenteroides on immune modulation in Newcastle Disease vaccinated chicken. Humoral immune response was assessed by ELISA. Th1, Th2 cytokine response and cell mediated immune response were assessed by using Real time PCR and flow cytometry respectively. Results indicated significantly (p less than 0.01) higher antibody titer and also higher IL-2, IL-12, IL-4 and IL-10 cytokine expression in NDV vaccinated multispecies probiotic fed group compared to commercial probiotic fed and control groups. It was also observed that higher proportions of Bu1A (B cell receptor) and CD3 (T cell receptor) positive cells in chicken fed with multispecies probiotic supplementation. Hence, it is concluded that multispecies probiotic played an important role in augmenting humoral and cell mediated immune response against NDV.
Polymorphism of Beta (â) Casein Gene and Their Association with Milk Production Traits in Malvi and Nimari Breeds of Cattle
Authors: Pandey Akhilesh , Thakur M. S. , Pandey Y.
Published: November 2019

Research work was carried out on 50 Malvi and 50 Nimari breed of cattle in the Department of Animal Genetics and Breeding of College of Veterinary Science and A.H Jabalpur. In present research work the PCR amplified products of 121bp was digested by restriction endonuclease enzyme DdeI, which recognizes G^AATTC sites. Present study showed that the presence of no restriction sites for the enzyme DdeI and only one band of 121bp was observed on the gel and such genotype was designated as A2A2 type. The â- casein gene showed A2A2 genotypes were observed in Malvi and Nimari breeds of cattle. The result of RFLP revealed that the gene and genotypic frequencies of â-casein (CSN2) gene for A2A2 was 1.00 for both Malvi and Nimari breed of cattle. So 100% frequency of A2 allele was observed in both the breeds of cattle under the study.
Agustín y la barba dorada de Hércules = Augustine and the golden beard of Hercules
Authors: San Vicente González de Aspuru Jose Ignacio
Published: November 2019

Resumen: En medio de un clima de conflicto religioso entre cristianos y paganos, la barba dorada de una estatua de Hércules en Cartago fue “afeitada” por un grupo de cristianos en el año 401. El 16 de junio de ese mismo año, Agustín pronunció un sermón (24) ante sus correligionarios en Cartago en el que analizó los hechos desde una óptica cristiana. En el artículo se examinan los datos sobre la estatua de Hércules, el significado de la barba en el mundo antiguo, el conflicto religioso, la normativa legislativa al respecto y el enfoque del obispo de Hipona sobre la estatua de Hércules, concluyéndose que la interpretatio de Agustín sobre el sentido simbólico de la barba está mediatizada por la figura bíblica de Sansón.Abstract: In the middle of a climate of religious conflict between Christians and pagans, the gilded beard of a statue of Hercules in Carthage was “shaved” by a group of Christians in the year 401. On June 16 of the same year, Augustine delivered a sermon (24) to his coreligionists in Carthage in which he analyzed the facts from a Christian perspective. The article examines the data on the statue of Hercules, the meaning of the beard in the ancient world, the religious conflict, the legislative norms on the matter and the approach of the bishop of Hippo on the statue of Hercules, concluding that Augustine’s interpretation of the symbolic meaning of the beard is mediated by the biblical figure of Samson.Palabras clave: Cartago, Código Teodosiano, cristianos, estatua, paganos.Key words: Carthage, christian, Codex Theodosianus, pagan, statue.
Heliogábalo vestido divinamente: a indumentária religiosa do imperador sacerdote de Elagabal = Heliogabalus divinely dressed: the religious clothes of Elagabalus’ priest emperor
Authors: Corsi Silva Semíramis
Published: November 2019

Resumo: Heliogábalo foi um jovem imperador romano de origem siríaca e membro da dinastia dos Severos (193-235). Seguindo uma tradição familiar, Heliogábalo foi sacerdote do deus solar Elagabal, da cidade de Emesa, na Síria. Diante de uma análise da documentação textual contemporânea de Heliogábalo, cruzada com análises das moedas emitidas no governo do imperador, apresentarei elementos sobre suas vestimentas sacerdotais de culto a Elagabal, consideradas na documentação textual antiga como cross-dressing, ou seja, transitando entre as fronteiras normativas de gênero da época. Analisarei a representação de sua indumentária religiosa e também relacionarei a essa representação a ideia trazida por Dião Cássio sobre a tentativa de Heliogábalo em fazer uma intervenção cirúrgica em seu corpo, buscando construir uma vagina nele. Também relacionado à sua indumentária religiosa, apresentarei a análise sobre a possibilidade do que seria um símbolo sacerdotal encontrado na imagem da cabeça do imperador em algumas de suas moedas. Abstract: Heliogabalus was a young Roman emperor from a Syriac origin and member of the Severan dynasty (193-235). Following a family tradition, Heliogabalus was the priest of the solar god Elagabal, from the city of Emesa, in Syria. Developing an analysis of the contemporary textual documentation of Heliogabalus, crossed with analyzes of the coins issued in the emperor's government, I will present elements about his priestly clothes of worship to Elagabalus, which were considered in the ancient textual documentation as cross-dressing, in other words, transitioning the normative gender boundaries of that time. I will analyze the representation of his religious dress and relate to this representation the idea brought by Cassius Dio about the attempt of Heliogabalus to make a surgery intervention in his body, seeking to build a vagina. Also related to his religious clothes, I will present the analysis on the possibility of what would be a priestly symbol found in the image of the emperor's head on some of his coins.Palavras-chave:Império Romano, dinastia dos Severos, Heliogábalo, Elagabal, Performances cross-dressing.Key words: Roman Empire, Severan dynasty, Heliogabalus, Elagabalus, Cross-dressing performance.
Szabó, Csaba: Sanctuaries in Roman Dacia. Materiality and religious experience (Roman Archaeology 49), Oxford: Archaeopress, 2018
Authors: Carbó Juan Ramón
Published: November 2019

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Bjelland Kartzow, Marianne: The slave metaphor and gendered enslavement in early Christian discourse: double trouble embodied, London-New York: Routledge, 2018
Authors: Gonzales Antonio
Published: November 2019

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“Die Künstlerische Betrachtungsweise…”: Wittgenstein on miracles = “Die Künstlerische Betrachtungsweise...”, Wittgenstein sobre los milagros
Authors: Sánchez Durá Nicolás
Published: November 2019

Abstract: Miracles are certainly a matter for the philosophy of religion. A defence is here raised, however, of the idea that Wittgenstein’s conception of miracles is closely connected with the artistic way of seeing in general, and with the consideration of literary fiction in particular. The connection can be established through a family of closely related concepts: “seeing as”, “the dawning of an aspect”, “image” and “perspective”. They are all involved in Wittgenstein’s aesthetic conceptions, in his analyses of art and also in his conception of miracles.Key words: Wittgenstein, miracles, art, religion.Resumen: Los milagros son ciertamente una cuestión de filosofía de la religión. En cualquier caso, me gustaría defender que la concepción de los milagros de Wittgenstein está íntimamente conectada con la forma de contemplación artística en general y con la consideración de la ficción literaria en particular. La conexión puede establecerse a través de una familia de conceptos relacionados: «ver como», «el fulgurar de un aspecto», «imagen» y «perspectiva». Estos conceptos están incluidos en las concepciones estéticas de Wittgenstein, en sus análisis del arte y también en su concepción de los milagros.Palabras clave: Wittgenstein, milagros, arte, religión.
La decoración vegetal de Estíbaliz “ante el tiempo”. Fluctuaciones en los significados iconográficos a la luz de la historiografía artística = The botanical decoration of Estibaliz “Devant le temps”: Fluctuations of iconographic meaning in the light of artistic historiography
Authors: López de Munain Gorka
Published: November 2019

Resumen: La portada Speciosa de la iglesia de Nuestra Señora de Estíbaliz (Álava) cuenta con una decoración vegetal sumamente rica y variada. Sin embargo, los investigadores que se han ocupado de su estudio han aportado visiones radicalmente opuestas, dividiéndose entre quienes consideraban su decoración como mero ornato y quienes apreciaban complejos simbolismos comprensibles sólo a la luz de los textos sagrados. Este singular caso de estudio nos permitirá reflexionar sobre el propio acto de historiar y sobre el modo en el que se relacionan las imágenes con el tiempo y con las personas que protagonizan cada una de las etapas en las que éstas son reactivadas. En un caso particular en el que no es posible conocer las motivaciones o intenciones de los constructores de esta portada, comprobaremos el valor de apreciar esos otros instantes en los que las imágenes son reapropiadas para un nuevo uso, estudio o interpretación.Palabras clave: iconografía vegetal, Nuestra Señora de Estíbaliz, historiografía, Ramiro de PinedoAbstract: The Speciosa portal of the church of Our Lady of Estíbaliz (Álava) has a rich and varied botanical decoration. The researchers who have studied it have, however, developed radically opposed interpretations, dividing those who consider the decoration merely as ornament and those who appreciate complex symbolisms connected with sacred texts. This case study will allow us to think about the very act of historicising and about how the images are linked with time and with the people involved in every stage in which the images are reactivated. In a case such as this, where it is not possible to know the motivations or intentions of the builders of the portal, we will appreciate the value of considering those other instants in which the images are reappropriated to give them a new use, study or interpretation.Key words: botanical iconography, Our Lady of Estíbaliz, historiography, Ramiro de Pinedo.
Necrópolis romana de Carmona. Un proyecto innovador de gestión cultural (1881-1930)
Authors: Rodríguez Gutiérrez Oliva
Published: November 2019

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Characteristics of the Concentric Eyewall Structure of Super Typhoon Muifa during Its Formation and Replacement Processes
Authors: Bo Tonggui , Liu Yudi , Li Dawei , Huang Lang , Yu Yi
Published: November 2019

To explore the characteristics of the concentric eyewall of a typhoon during its formation and replacement processes, with Super Typhoon Muifa in 2011 as the example case, the Weather Research and Forecast (WRF) mode was used to carry out a numerical simulation to reproduce the entire formation and replacement processes of the concentric eyewall. The physical quantities such as the tangential wind speed, radar echo, radial wind speed, vertical wind speed, and potential vortex were diagnosed and analyzed. The results of the analysis show that the outward expansion of the isovelocity in the lower troposphere was the early signal of the formation of the outer eyewall. After the outer eyewall formed, there was a center of second-highest tangential wind speed in the corresponding area. The second-highest wind speed increased as the strength of the outer eyewall increased, and the position of the second-highest wind speed center was retracted with the retraction of the outer eyewall. The tangential wind speed of the moat area was smaller than that corresponding to the concentric eyewall and this feature gradually disappeared with the increase of the height. The echo in the moat area was weak, and this characteristic was particularly evident when the moat area was relatively wide and the outer eyewall was relatively strong. With the formation and development of the outer eyewall, the intensity of the inflow in the boundary layer corresponding to the inner eyewall was reduced, the intensity of the outflow in the upper layers declined, and the intensities of the inflow and outflow corresponding to the outer eyewall were enhanced. After the second outer eyewall matured, there was a significant inflow in the upper layer of the moat area. Once the outer eyewall formed, a large amount of hydrometeors appeared in the corresponding area, and there was a strong ascending motion inside that area. The strength of the ascending motion and the content of hydrometeors increased as the outer eyewall increased. When the moat area was relatively wide, the divergent airflow generated by the developed outer eyewall in the upper layer would produce a significant descending motion in the moat area.
Pengelolaan Pola Tanam Berbasis Kedelai dan Jagung di Lahan Kering
Authors: Arifin Zainal , Tafakresnanto Chendy
Published: November 2019

Penelitian bertujuan memperoleh teknologi pola tanam berbasis kedelai dan jagung yang dapat meningkatkan produktivitas lahan dan pendapatan usahatani di lahan kering. Penelitian dilaksanakan di Kecamatan Arjasa, Kabupaten Situbondo dan di Kecamatan Manding, Kabupaten Sumenep pada musim kemarau (MK 1 dan MK 2 tahun 2018) dengan luasan 1 ha. Di masing-masing lokasi, penelitian dimulai dengan melakukan pengamatan pada pertanaman petani yang ditanam pada awal musim hujan (MH), dilanjutkan dengan menanam jagung dan kedelai sesuai penelitian pola tanam yang dirancang. Di Situbondo, pada awal MH petani menanam padi tanam pindah (tapin) varietas Ciherang, dan di Sumenep petani menanam jagung varietas BISI 18. Setelah tanaman di MH dipanen di masing-masing lokasi, penelitian dilaksanakan mengikuti pola tanam jagung dan kedelai menggunakan rancangan acak kelompok, 4 perlakuan diulang 6 kali. Pola tanam yang diteliti terdiri atas : a) jagung (75 cm x 20 cm) / / jagung (75 cm x 20 cm), b) jagung double row (100 cmx50cmx20cm)//kedelai(40cmx15cm),c) jagung (160 cm x 40 cm) / kedelai (40 cm x 15 cm), dand)kedelai(40cmx15cm)–jagung(75cmx20 cm). Hasil penelitian menunjukkan bahwa di Situbondo pola tanam padi tapin-jagung//jagung mampu memberikan hasil tertinggi, yakni setara dengan hasil kedelai 12,7 t/ha dengan nilai IIT 0,82. Pada MK 1, sistem tanam jagung double row memperoleh hasil 7,542 t/ha pipilan dan pangkasan daun jagung 7,894 t/ha dengan pendapatan Rp27.581.100/ha dan R/C 2,97. Di Sumenep hasil terbaik diperoleh pada pola tanam jagung-kedelai-jagung, yakni setara dengan hasil kedelai 9,3 t/ha dengan nilai IIT 0,76. Pada MK I sistem tanam tumpangsari kedelai (2,385 t/ha biji) dan jagung (2,775 t/ha pipilan), ditambah hasil pangkasan daun jagung (2,025 t/ha) menghasilkan pendapatan Rp24.326.200 dengan nilai R/C 2,06. 
Isoniazid preventive therapy utilization rate and associated factors in adult HIV/AIDS patients in Jimma University Specialized Hospital ART clinic, Oromia Region, Ethiopia: A cross-sectional study.
Authors: Jaleta Gudeta Imana , Rajamanickam Vinodhini , Woldemichael Kifle
Published: November 2019

Background: Tuberculosis (TB) is the most frequent life-threatening infection and a common cause of death for people living with HIV (PLHIV). The influence of TB and HIV infection has enhanced the magnitude of both epidemics. Several clinical interventions recommended early diagnosis in PLHIV and treating latent TB infection (LTBI) with Isoniazid preventive therapy (IPT) along with antiretroviral therapy (ART). IPT is one of the key interventions recommended by the world health organization (WHO) for the prevention of TB in patients infected with HIV. Hence, this study aimed to determine IPT utilization rate among adult HIV infected patients enrolled in HIV care and qualitative analysis, which explore the factors that influence IPT use among PLHIV under follow-up, Health care providers (HCPs) and TB/HIV coordinators working in Jimma University Specialized Hospital (JUSH) ART clinic. Methods: An Institution based mixed cross-sectional study was conducted in JUSH ART clinic. Adult HIV infected patients were enrolled by a systematic sampling technique from the registered medical records of JUSH HIV care. PLHIV who were on follow-up and eligible for IPT during the study period, permanent HCPs and TB/HIV coordinators working in ART clinic were included in the qualitative investigation using semi-structured questioners and in-depth interviews. All statistical analysis was compiled by Epi data 3.1 and SPSS 20. Results: Demographic and clinical factors are not significantly associated with IPT use but ethnicity (P≤ 0.02**) was highly significant with IPT use in logistic regression model. Overall, 59.2% of the patients have been prescribed and taken at least one-month course of IPT. The results of in-depth interviews are grouped into three core categories as patient perceptions, HCPs and TB/HIV coordinator perspectives. Discussion and conclusion: PLHIV, HCPs and TB/HIV coordinators suggested their overall response as periodic counseling for target groups, educating the benefits of IPT and increasing public awareness on TB prophylaxis in PLHIV will increase the acceptance and implementation of IPT in large scale. Higher attention should be provided in linking all HIV patients to the nearest health facilities for receiving free service packages and medical care. Key words: IPT, TB /HIV, PLHIV, ART, INH prophylaxis
The use of visual risk communication and its significance for risk understanding and health literacy in out-clinic settings – a literature review
Authors: Jensen Louise Drejer , Nielsen Jesper Bo , Jensen Anders Elkær
Published: November 2019

Background Patients frequently experience difficulties understanding communicated risks. The aim of this study was through a literature review to analyze if the use of visual risk communication tools improve risk understanding among patients in outpatient settings or general practice, and if one tool appears more useful than others. Method The electronic databases PubMed and PsycINFO were systematically searched. Relevant references were used for chain search to make sure all relevant literature was included. Results The main search revealed 1,157 titles. There were 13 eligible studies concerning visual risk communication in outpatient clinical settings. The design, quality and main findings of the studies were heterogeneous. However, most of the analysed studies found a significant positive effect of graphical, interactive and dynamic visual aids on risk communication. Conclusion There is currently not enough evidence to endorse one graphical format above others. Personalising the graph format to the type of risk information presented may facilitate a better understanding of risk and contribute to improve health and cost-efficacy.
Live imaging of mRNA using Pepper RNA-stabilized fluorogenic proteins
Authors: Wu Jiahui , Jaffrey Samie
Published: November 2019

mRNA plays critical roles in cell biology. Here, we describe the procedures of imaging mRNA using Pepper RNA-stabilized fluorogenic proteins in living cells.
Validation Of Cariogram In Caries Prediction At Woman And Their Children 4 Years After Pregnancy – Longitudinal Study
Authors: Dolic Olivera , Obradovic Marija , Kojic Zeljka , Trtic Natasa , Sukara Slava , Knezevic Natasa , Veselinovic Valentina
Published: November 2019

Background: The Cariogram®, an algorithm based software model, for predicting caries risk has been used to assess the caries risk profile of many different groups. Early childhood caries (ECC) is the most common chronic disease in children below 71 months of age. Identifying children at greatest risk of caries to design appropriate preventive activity has been a goal of the dental profession for many years. The aim of the study was to evaluate Cariogram caries risk assessment during pregnancy with DMFT/dmft incidence at mother and their children 4-years later. Methods: The study population consisted of 96 pregnant women (average age 27.4 years at baseline) that completed clinical baseline examination and salivary tests. A caries risk assessment was made using Cariogram model and according to it, participants were divided into five risk groups. The follow-up study was initiated 4 years later and the 80 pairs of mother and children (from that pregnancy) were re-examined using the same procedure as did at baseline. An individual caries risk profile and DMFT/dmft incidence were made for each woman and child. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for two cut-offs were calculated to express the outcome.
Results: There was a strong association between the risk categories of pregnant women and their offspring as well as between caries development in children and the Cariogram risk categories of their mother in pregnancy. Sensitivity and PPV for new DMFT (ΔDMFT > 0) over 4 years for women was high (>80%) for those participants assessed with 0-60% “chance to avoid caries“, as well as diagnostic accuracy (74.00%). High specificity (91.00%), very high PPV (95.00%) and clinically useful values according to Youden’s index (0.53) were obtained for moderate and two lowest risk groups for dmft in children.
Conclusions: With the limits of this study, Cariogram model can be useful tool for caries prediction in both groups of woman and their children based on caries risk assessment during pregnancy. The Cariogram was valid and highly predictive in caries risk assessment in children based on caries risk assessment of their mother in pregnancy.
Spatial analysis of confirmed Lassa fever cases in Edo State, Nigeria, 2008 – 2014
Authors: Owoicho Samuel Amifofum , Awosanya Emmanuel , Fadugba Dorcas , Balogun Muhammad Shakir , Nguku Patrick , Ajisegiri Simon , Eugene Odigie , Olugasa Babasola
Published: November 2019

Background: Lassa fever (LF) is endemic and poses public health threats in Edo State. Identification of primary clusters will help prioritize public health interventions in the state. We investigated retrospective cases of LF to identify primary cluster of the disease for household exposure management. Method: We reviewed retrospective data (n = 1400) of LF case-patients at a referral hospital in Edo State from 2008 to 2014 based on World Health Organization case definition for LF. We determined primary cluster of confirmed cases on Bernoulli model and evaluated environmental factors in the primary cluster: presence of rodent deterrents, proximity of households at 2 km radius to rice farm, rice post-harvest storage facility, refuse dump, forest, hospital and main road using Multi-criteria analysis at p < 0.05. Results: Of the reviewed cases, 171 (12.2%) were confirmed case-patients. The median age of confirmed case-patients was 30 years (Q1:16.0 and Q3: 43.5). Of the confirmed case-patients, 101 (59.1%) were male. A primary spatial cluster (4.45 km radius; geographic centre at 6.717900oN, 6.243500oE) was identified in Esan West LGA. Associated environmental factors included presence of rodent deterrents (p < 0.001), proximities of households to refuse dump (p < 0.001), rice post-harvest storage facility (p = 0.01) and rice farm (p = 0.03). Conclusion: Esan West LGA was identified as a primary cluster for Lassa fever. Presence of rodent deterrents, household proximity to refuse dump sites, rice storage facilities and rice farms were associated environmental factors. We recommend improved rice post-harvest storage and use of rodent deterrents in Edo State, Nigeria. Key words: Multi-criteria analysis, Lassa fever, environmental variables, Nigeria.
Analysis of deep sequencing Exosome-microRNA expression profile from Chicken Type Ⅱ Pneumocytes derived reveals potential role of gga-miRNA-451 in inflammation
Authors: Zhao Yabo , Fu Yali , Zou Mengyun , Sun Yingfei , Yin Xun , Niu Lumeng , Peng Xiuli
Published: November 2019

Background: Exosomes are nanosized extracellular vesicles secreted by multiple cells in the body, including those located in the respiratory tract and lungs. They are emerging as important inflammatory mediators and can release their contents, especially microRNAs (miRNAs), to both neighboring and distal cells. Mycoplasma gallisepticum (MG) can target host cell and cause chronic respiratory disease (CRD) in chickens. Although exosomal miRNAs have been demonstrated to produce an important effect on microbial pathogenesis and inflammatory response as crucial regulatory noncoding RNAs, the mechanism by which exosomal miRNAs regulate MG-induced inflammation remains to be elucidated. Methods: the expression of exosome-microRNA derived from MG-infected chicken type Ⅱ pneumocytes (CP-Ⅱ) was screened, and the target genes and function of differentially expressed miRNAs (DEGs) were predicted. To verify the inflammatory functions of exosomal gga-miR-451 via targeting YWHAZ, Western blot, ELISA, and RT-qPCR were used in this study. Results: A total of 722 miRNAs were identified from the two exosomal small RNA (sRNA) libraries, and 279 novel miRNAs were discovered; 30 miRNAs (9 up-regulated and 21 down-regulated) were significantly changed (P＜0.05). Function annotation analysis of DEGs showed that the target miRNAs were significantly enriched in treatment group, such as cell cycle, Toll-like receptor signaling pathway and MAPK signaling pathway, etc. The results have also confirmed that gga-miR-451-absent exosomes derived from MG-infected CP-Ⅱ cells increased inflammatory cytokine production in DF-1 (chicken embryo fibroblast) cells, and Wild Type CP-Ⅱ cells-derived-exosomes displayed protective effects. Conclusion: our work suggests that exosomes from MG-infected CP-Ⅱ cells alter the dynamics of the DF-1 cells, and may contribute to pathology of the MG infection via exosomal gga-miR-451 targeting YWHAZ involving in inflammation. This could potentially be used as a biomarker for diagnostics and treatment.
Pregnant women with gestational diabetes mellitus exhibit unique features in oral microbiome
Authors: Li Xiaoqing , Zheng Jiayong , Ma Xiuling , Zhang Bing , Zhang Jinyang , Wang Wenhuan , Sun Congcong , Wang Yeping , Zheng Jianqiong , Chen Haiying , Tao Jiejing , Wang Hai , Zhang Fengyi , Wang Jinfeng , Zhang Hongping
Published: November 2019

Background Gestational diabetes mellitus (GDM) leads to a series of adverse pregnancy outcomes, seriously endangering the health of mothers and infants. Oral glucose tolerance test (OGTT) is the gold standard test for GDM diagnosis, but largely increases the discomfort of pregnant women, and is inconvenient to follow-up and detection. Considering that oral sampling is convenient, rapid, safe and non-invasive, the feasibility of distinguishing GDM via biomarkers from oral microbiota was evaluated in this study. Here, the 16S rRNA gene sequencing was used to compare the microbiome of saliva and dental plaque samples of 111 pregnant women, and to analyze the structure of oral microbiota in patients with GDM as well as to find effective biomarkers.Results The results showed that the microbiota of both types of oral samples in patients with GDM changed, and it was quite different from that of neither periodontitis nor dental caries. By using bacterial biomarkers from oral microbiota, GDM classification models based on SVM and random forest algorithms were constructed. For the SVM algorithm, the AUC value of the classification model constructed by the combination of dental plaque Lautropia, Neisseria and saliva Veillonella achieved 0.83. For the random forest algorithm, the maximum AUC value of the model constructed by the dental plaque Streptococcus, Eikenella, Anoxybacillus and saliva Leptotrichia, Kingella was larger than 0.90.Conclusions These findings revealed that certain bacteria of either saliva or dental plaque can accurately distinguish GDM from healthy pregnant women, which provides a potential non-invasive approach for GDM diagnosis with oral microbial markers.
Silencing of FOXG1 confers radio-sensitivity through regulating autophagy in glioma cells
Authors: Liao Wenjun , Li Churong , Yin Jun , Huang Hui , Li Baisen , Zhang Shichuan , Zhang Peng , Yang Chuan
Published: November 2019

Background/Aim forkhead box G1 (FOXG1) has recently been observed in many cancers, while its effect on radio-sensitivity in glioma is still unclear. In this study, we hypothesized that FOXG1 be a major players in radio-resistance of glioma as well as the underlying mechanism.Methods Immunohistochemistry (IHC) was conducted to assess FOXG1 expression in the glioma tissues and glioma-adjacent tissues. Western Blot was applied to detect the expression of autophagy-related proteins. CCK-8 and flow cytometry assays were applied to assess proliferation and apoptosis, respectively.Results The present study demonstrated that FOXG1 was highly expressed in glioma tissues. FOXG1 silencing enhances the effect of X-ray irradiation on proliferation inhibition and apoptosis of glioma cells, while FOXG1 overexpression has the opposite effect. Interestingly, the chloroquine (CQ) of autophagy inhibitor enhanced X-ray irradiation induces proliferation inhibition and apoptosis in glioma cells.Conclusions The present study suggests that FOXG1 is a pivotal molecule for circumventing radiation-induced cell death in malignant glioma cells through the regulation of autophagy and provide a target for the treatment of human brain glioma.
Differential effects of bisphosphonates and denosumab on primary breast cancer risk, potentially to be modified by statins
Authors: Stanoyevitch Alexander , Zhang Lei , Sanz Javier , Follett Robert , Bell Douglas
Published: November 2019

Background The risks of osteoporosis and breast cancer are increasing in elderly women, as well as menopausal status related hyperlipidemia. Bisphosphonates and denosumab, varying in drug mechanisms and therapeutic effects are recommended medications for treatment of osteoporosis. The pharmacodynamics of bisphosphonates and statin overlap in one signal pathway. We aim to assess different effects of bisphosphonates and denosumab on breast cancer, possibly modifiable by statins use. Methods This cohort study includes 97,671 women elder than 50 years without previous history of malignancy. Results Over an average of 3.6 years follow up, 3020 women have received either denosumab (n=778) or bisphosphonates (n=2326) for osteoporosis, among them, 84 (84/3020=2.8%) patients have combination medication of both. Our data demonstrated significant difference in breast cancer occurrence after first year latency between denosumab ever prescription group (12/778, 1.54%) and bisphosphonates group (12/2326, 0.52%), P=0.0046; this significance is also proved by Log-rank test (p=0.0004). Although the breast cancer risk in bisphosphonates ever use group (12/2326, 0.52%), statins ever use group (99/15287, 0.65%), hormone users for menopausal symptoms (20/7631, 0.26%) are significantly lower than control patients (1032/74867, 1.38%), p<=0.004, there is no significant difference in breast cancer risk between denosumab group and control patients (p=0.6965). Further subgroup analysis revealed that concurrent use of statins in denosumab prescribers lowered the breast cancer risk to 0.89% (2/224), but with no significantly change of breast cancer risk in bisphosphonates group (7/919, 0.762%). Conclusion Our data suggest superior protective effects of bisphosphonates over denosumab on breast cancer risk in elderly women. Statins could potentially exert breast cancer protective effect in denosumab users but no synergistic effect in patients taking bisphosphonates. Large scale study with long term follow up is needed
Study of the co-expression gene modules of non-small cell lung cancer metastases
Authors: Wang Guanghui , Bie Fenglong , Li Guangxu , Shi Junping , Zeng Yanwu , Du Jiajun
Published: November 2019

Background: Metastasis regularly is a marker of the disease development of cancers. Some metastatic sites significantly showed a more serious clinical outcome in non-small cell lung cancer (NSCLC). Whether they are caused by tissue-specific (TS) or non-tissue-specific (NTS) mechanisms is still unclear. Methods: Weighted Correlation Network Analysis (WGCNA) was used to identify the gene modules among the metastases of NSCLC. The clinical significance of those gene modules was evaluated with the Cox hazard proportional model with another independent dataset. Functions of each gene module were analyzed with gene ontology. Typical genes were further studied. Results: There were two TS gene modules and two NTS gene modules identified. One TS gene module (green module) and one NTS gene module (purple module) significantly correlated with survival. This NTS gene module (purple module) was significantly enriched in the epithelial-to-mesenchymal transition (EMT) process. Higher expression of the typical genes ( CA14 , SOX10 , TWIST1, and ALX1 ) from EMT process was significantly associated with a worse survival. Conclusion: The lethality of NSCLC metastases was caused by TS gene modules and NTS gene modules, among which the EMT-related gene module was critical for a worse clinical outcome.