bluuebunny/crossref_metadata_2025 huggingface dataset:
Mean Subpubic Angle of Patients Visiting Department of Radiodiagnosis of a Tertiary Care Hospital: A Descriptive Cross-sectional Study
Authors: Pandit Ruku , Adhikari Aarati , Upadhyay Hari Prasad
Published: February 2022

Introduction: The subpubic angle in the pelvis is most often used to estimate the sex with a higher degree of accuracy. Despite the anthropological and obstetric importance of the subpubic angle, only a few studies exist in the Nepalese population. The objective of this study was to determine the mean subpubic angle of the patient visiting the department of radiodiagnosis of tertiary care hospital.
Methods: This was a descriptive cross-sectional study comprising 332 pelvic digital radiographs of the patients visiting the department of radiodiagnosis of a tertiary care center from March to August, 2021. Ethical approval was taken from the Institutional Review Committee at College of Medical Sciences (Reference number: COMSTH-IRC/2021-62). Convenience sampling method was done. Demographic data like age and sex were noted. In the radiograph, the subpubic angle was measured using the program Digimizer Image Analysis Software. The collected data were analysed using the Statistical Package for the Social Sciences version 20. Point estimate at 95% Confidence Interval was calculated along with mean and standard deviation for continuous data.
Results: Among 332 pelvic radiographs studied, the mean subpubic angle was found to be 120.42±22.27° (118.02-122.81 at 95% Confidence Interval). The subpubic angle in females was 137.96±12.47° and that in males was 101.10±12.56°.
Conclusions: Our findings are similar to those of other studies, with a minor variation. The subpubic angle was comparatively higher in females than males in the present study. The findings of this study may be of interest to forensic scientists and obstetricians.
A Baby Born with Ectopia Cordis, Omphalocele, Cleft Lips and Palate: A Case Report
Authors: Shrestha Nischal
Published: February 2022

Ectopia cordis is a rare congenital defect with the prevalence of 5 to 8 per million live births. Here we report a rare case of preterm female live birth with ectopia cordis associated with omphalocele, cleft lip, and palate. In this case, 14+ weeks ultrasound did not show any fetal abnormalities and parents were unaware of the condition until 35+ weeks when ultrasound detected the anomaly a few days before delivery. After delivery, they didn’t give consent for further intervention which led to neonatal mortality 3 hours after birth. If the condition was diagnosed in time, an earlier intervention could have been done.
Coronary Artery Bypass Grafting among Patients Undergoing Cardiac Surgery in a Tertiary Care Hospital: A Descriptive Cross-sectional Study
Authors: Sharma Praman , Yadav Lokesh , Nepal Rajesh , Khanal Sunil Babu , Agrawal Subhadra , Kattel Vivek
Published: February 2022

Introduction: Among all cardiac surgeries, coronary artery bypass graft is frequently performed and is expected to improve the quality of life in patients with coronary artery disease. This study aimed to look at the prevalence of the patients undergoing coronary artery bypass grafting among cardiac surgery cases at a tertiary care hospital.
Methods: This was a descriptive cross-sectional study conducted at the Cardio-Thoracic and Vascular Surgery department of a tertiary care hospital among 92 patients who underwent cardiac surgery. Participants were enrolled after the ethical clearance from the Institutional Review Committee (Reference number: 574/2019). Epidemiological characters, functional New York Heart Association classification, and left ventricular function were evaluated. Data were entered in Microsoft Excel 2010 and analyzed using Statistical Package for the Social Sciences version 20. Point estimate at 95%Confidence Interval was calculated along with frequency and proportion for binary data.
Results: The prevalence of coronary artery bypass graft in patients undergoing cardiac surgery was 49 (53.2%) (43.0-63.4 at 95% Confidence Interval). The mean age of 49 patients was 58.87 years. Hypertension 43 (88%), Dyslipidemia 34 (69%) and Type 2 Diabetes Mellitus 25 (51%) were major comorbidities. The mean preoperative and postoperative ejection fraction was 48.2±10.5% and 52.6±6.0% respectively. The preoperative median New York Heart Association class was 3 whereas the post-operative class was 1. Mortality was seen in one (2.04%) patient.
Conclusions: The prevalence of coronary artery bypass graft in the patient undergoing cardiac surgery was lower than noted in other studies.
Primary Grynfeltt Lumbar Hernia: A Case Report
Authors: Basnet Krity , Bhandari Rupa , Shah Shiv Raj , Limbu Yugal , Ghimire Roshan
Published: February 2022

A weakening or defect in posterolateral abdominal wall can lead to development of lumbar hernia. These defects are particularly common in Petit's inferior triangle or Grynfeltt-Lesshaft superior triangle. There are very few cases of primary lumbar hernias that have been described in literature till date. As it is a rare entity, it is often misdiagnosed, leading to delay in management. We present a case of a 66-year-old male with no previous surgery who presented with a mass in left lumbar region for last ten years. The mass gradually increased in size and caused vague dragging pain. On Computed tomography, the diagnosis of Grynfeltt hernia was made. The patient underwent a laparoscopic mesh repair and had an uneventful postoperative hospital stay. Although a rare entity, there should be a high degree of suspicion of a lumbar hernia when evaluating a case of a lumbar mass. Early diagnosis by computed tomography and management with open or minimally invasive techniques can prevent complications.
Pengaruh Kualitas Produk,Kualitas Pelayanan Dan Media Sosial Terhadap Keputusan Pembelian ( Studi Pada UKM Makaroni Bantet Banyuwangi )
Authors: Hotimah Husnul , Firdaus Muhammad , Amin Saiful
Published: February 2022

This study aims to determine the effect of product quality, service quality, and social media on purchasing decisions for macaroni bantet Banyuwangi. This study is based on quantitative methods, the data used in this study are primary data obtained from respondents' responses to questionnaires. Samples were taken as many as 100 respondents with a sampling technique using a simple random sample. The data obtained is then processed using SPSS analysis tools, analysis method using multiple linier regression analysis. The results showed that the variables of product quality, service quality, and social media had a simultaneous effect on purchasing decisions.
Pengaruh Kualitas Produk, Kualitas Pelayanan Dan Citra Perusahaan Terhadap Kepuasan Konsumen PT. FIFGROUP Cabang Jembe
Authors: Setiawan Heri , Sulaksono Hary , Haifa Haifa
Published: February 2022

The purpose of the study was to determine the effect of product quality, service quality and corporate image on customer satisfaction at PT FIFGROUP Jember Branch. The population in this study were consumers of PT FIFGROUP Jember Branch, amounting to 80 consumers who were used as respondents. The analytical model used in this study is multiple linear regression analysis. The results showed that partially product quality and service quality had an effect on consumer satisfaction, while the company image had no effect on consumer satisfaction. And simultaneously the three independent variables (product quality, service quality and company image) affect variable Y (customer satisfaction) PT FIFGROUP Jember Branch.
Analisa Kepuasan Pelanggan Pengangkutan Sampah Menggunakan Metode Importance Performance Analysis (Studi Kasus Pada Dinas Lingkungan Hidup Kabupaten Jember)
Authors: Dewantara Harvian Bagus , Sulaksono Hary
Published: February 2022

This study aims to determine what quality dimension attributes have met customer satisfaction for waste transportation of the Department of the Environment of Jember Regency. The data used in this study are primary data. The data processing method in this study uses the Data Instrument Test Analysis method, namely: Validity Test and Reliability Test, and uses the Importance Performance Analysis (IPA) analysis method, using 5 service quality dimension attributes, namely Physical Evidence (Tangibles), Reliability (Reliability), Responsiveness, Assurance, and Empathy (Emphaty). The results showed that the Reliability Dimension has a very low gap value, which indicates that the quality of service provided by the Environmental Service Office of Jember Regency is very satisfying for customers. Meanwhile, the dimension of responsiveness has the highest gap, which can be concluded that there is dissatisfaction for customers with the responsiveness of the Jember Regency Environmental Service in dealing with existing problems. This of course will become a reference for the Jember Regency Environmental Service in improving the quality of its services.
MOVIMIENTO ANTI-VACUNAS: VACUNAR O NO A NUESTROS HIJOS
Authors: Fernández Muñoz Priscila
Published: February 2022

Las vacunas son sustancias elaboradas contoxoides, bacteriasovirus, que se administran a las personas para crear inmunidad. Estas han mejorado con el ﬁn de ayudar a la medicina actual, erradicando distintas enfermedades, disminuyendo las tasas de mortalidad. Para entender el movimiento anti vacunas es necesario conocer la historia, origen y evolución del mismo. Este movimiento alega que la vacunación se impuso como una doctrina obligatoria creada para el control social y con intereses económicos de distintas casas farmacéuticas. La popularidad de estas ideas, ha provocado la reaparición de enfermedades que se creían extintas. Objetivo: Conocer la historia, antecedentes y eﬁcacia de las vacunas, así como de los grupos anti vacunas, para entender sus puntos de vista, mediante un análisis bibliográﬁco. Contexto: Los grupos anti vacunas surgieron al mismo tiempo que las vacunas, pero tomaron importancia a partir de la publicación de un artículo en el año 1998 en la revista “The Lancet” donde se relacionaba la “vacuna triple vírica”, para prevenir el sarampión, rubeola y parotiditis; con el autismo. En 2004 la revista retiró el artículo pues se demostró el fraude en esta investigación, sin embargo, el daño causado fue irreparable ya que surgieron dudas de las vacunas y por tanto los grupos tomaron fuerza. Metodología: Se empleó un análisisbibliográﬁcodelaliteraturaqueanalizaelmovimientoantivacunasdesdesusprincipios,condatoshistóricosycomo este se maniﬁesta en la actualidad, también se revisó evidencia cientíﬁca de la efectividad de las vacunas.
ARGIROSIS FOCAL, REPORTE DE UN CASO
Authors: Pesántez Alvarado Juan Martín
Published: February 2022

El tatuaje de amalgama representa una de las lesiones pigmentadas más comunes que puede encontrarse en la mucosa bucal, como consecuencia del depósito de partículas de material metálico dentro del epitelio, provocando una lesión macular característica, que debe ser incluida dentro de los diagnósticos diferenciales de lesiones pigmentadas de origen melanocítico. Se reporta el caso de una paciente de 58 años de edad, quien asistió al odontólogo por una odontalgia; en el examen intraoral se observó una lesión macular localizada en el reborde alveolar inferior derecho; luego de resuelto el motivo de consulta, se realizó una biopsia excisional conﬁrmándose el diagnóstico a través del examen histopatológico.
Frecuencia del biotipo facial en estudiantes de la carrera de Odontología de la UTE
Authors: Parise Vasco Juan Marcos
Published: February 2022

Introducción: Establecer el biotipo facial del paciente es esencial en varias áreas de la odontología, al permitirnos diseñar un mejor plan de tratamiento y conductas a seguir, busca evitar errores en la planificación y desarrollo del tratamiento.  Objetivo: Determinar la prevalencia de los diferentes biotipos faciales en estudiantes de la carrera de Odontología de la Universidad UTE, mediante el análisis cefalométrico de Ricketts y aplicación del índice VERT.  Métodos: Se planteó un estudio transversal descriptivo, considerando una muestra constituida por 79 estudiantes de últimos niveles de los periodos académicos 2018-2019. Cada participante fue sometido a un examen clínico para la valoración de hipertrofia amigdalar y desórdenes en la articulación temporomandibular. Para determinar el biotipo facial y patrón esqueletal se utilizó el análisis cefalométrico de Ricketts con el índice VERT. Los datos recolectados fueron analizados mediante estadística descriptiva, análisis de frecuencias, medidas de tendencia central y de dispersión. Resultados: El biotipo facial de mayor prevalencia fue el mesofacial.
Morfología de conductos radiculares en incisivos mandibulares permanentes mediante tomografía computarizada de haz cónico en una subpoblación cuencana
Authors: ALVAREZ VASQUEZ JOSE LUIS , Durán Urdiales Daniela Belén , GONZALEZ NEIRA CINTYA CAMILA
Published: February 2022

Objetivo: Evaluar la morfología de conductos radiculares en incisivos mandibulares permanentes usando tomografía computarizada de haz cónico (CBCT). Materiales y métodos: Se analizaron 187 archivos de CBCT de pacientes cuencanos, valorando un total de 748 imágenes tomográficas. Las CBCT fueron obtenidas usando un tomógrafo Morita 3D Accuitomo 170 (J. Morita Inc., Kyoto, Japan) con tamaño de vóxel de 0.330 mm; parámetros de exposición de 90 kV, 6 mA; campo de visión de 170 x 170; grosor de corte de 0.66mm. La configuración de los conductos radiculares fue analizada de acuerdo a la clasificación de Vertucci. La influencia del género en la distribución de conductos y la simetría de bilateralidad fueron analizados estadísticamente; el nivel de significancia fue p <0.05. Resultados: Todos los dientes presentaron 1 raíz. La prevalencia de dos conductos radiculares fue del 9%. En dientes con dos conductos radiculares, la configuración de Vertucci más prevalente fue el tipo III (6,7%), seguido del tipo V (1,6%). Además, el 68,7% de los dientes con dos conductos radiculares presentaron la bifurcación en el tercio medio de la raíz. No hubo diferencias estadísticamente significativas respecto a la influencia del género y la simetría de bilateralidad. Conclusiones: La prevalencia de dos conductos en incisivos mandibulares en una subpoblación cuencana fue del 9% aproximadamente, siendo la configuración de Vertucci III la más prevalente.
Prueba de micronúcleos en células bucales. Una revisión
Authors: COLCHADO CARHUAVILCA JORGE RAÚL
Published: February 2022

La prueba de micronúcleos se ha convertido en el método más utilizado para evaluar la genotoxicidad de diferentes factores biológicos, físicos y químicos, convirtiéndose poco a poco en un reconocido marcador de daño en el ADN para el biomonitoreo de diversas entidades sistémicas. Esta revisión está enfocada principalmente en la prueba de micronúcleos en células bucales, considerado en la actualidad como una prueba prometedora para ser utilizada como biomarcador de eventos patológicos, por las características que presenta al no ser invasiva, tolerada por lo pacientes y no requerir de una infraestructura compleja, como equipos de cultivo tisular, para llevarla a cabo. Como se sabe el fundamento de esta prueba es la detección de los micronúcleos, los cuales se originan a partir de cromosomas completos o fragmento de cromosomas que fueron rezagados por genotoxinas durante la mitosis.

 

Palabras clave. Micronúcleos, Mucosa bucal, Pruebas de mutagenicidad, ADN.
Encerado digital (PDTE) : Caso clínico
Authors: Villavicencio-Caparó Emilio , Cabrera Dora , Chuya Luz Mariela
Published: February 2022

Tradicionalmente la planificación en rehabilitación oral tiene un paso importante llamado encerado diagnóstico, en la actualidad el advenimiento de la odontología digital ha generado una nueva manera de realizar este proceso. En el presente caso clínico se exponen los aspectos más relevantes de la elaboración de un Prototipo Digital de Tratamiento Estomatológico (PDTE) en el caso de una paciente de 46 años con necesidad de tratamiento de cirugía, rehabilitación oral y periodoncia. Para realizar esta planificación se utilizó un escáner Dentsply Sirona inEos X5 Digital Dental Scanner, el software Autodesk MeshMixer versión 3.5 y la impresora 3D con el material de ácido poliláctico (PLA) finalmente el diseño PDTE se articuló digitalmente en un simulador de articulador BioArt dentro del software ExoCAD.
Tercer molar retenido, un problema de salud pública (Análisis antes y durante y durante la enfermedad Covid-19).
Authors: Enríquez Méndez Silvana , Palacios Vivar Diego , Vargas Chávez Luis
Published: February 2022

Los cambios que hemos sufridos los humanos, por la mezcla racial, herencia, cambios en los hábitos alimenticios, conducen a una incidencia cada vez más elevada de retención de piezas dentales y su consiguiente patología multisintomática. Las diversas indicaciones para realizar la extracción del tercer molar retenido son: alteraciones ortodónticas, protésicas restaurativas, periodontales o bien por una patología asociada (quistes, tumores ontogénicos, fracturas, infecciones). El objetivo del presente artículo es evaluar el tratamiento temprano del tercer molar retenido. Además se analizará brevemente el costo de su tratamiento quirúrgico y recuperación posoperatoria, abarcando desde medicación hasta el descuento del sueldo mensual que puede provocar la ausencia del paciente a su trabajo.
Unternehmen: Diktaturen oder Demokratien? Debatten zur Reform der Unternehmensverfassung
Authors: Nienhüser Werner
Published: February 2022

Die US-amerikanische Philosophin Elizabeth Anderson behauptet, dass Unternehmen Diktaturen sind: Die Kapitaleigner herrschten über die Beschäftigten. Kritik an solchen Verhältnissen gäbe es kaum. Das läge daran, dass eine in den Wirtschaftswissenschaften dominierende neoliberale Theorie der Firma diktatorische Unternehmensgovernance legitimiere. Im vorliegenden Beitrag werden folgende Fragen behandelt: Gleichen Unternehmen tatsächlich Diktaturen; und gilt dies auch für die mitbestimmten Unternehmen in Deutschland? Trifft der Vorwurf der Legitimation von Unternehmensdiktatur die neueren Theorien der Wirtschaftswissenschaften? Welche Vorschläge für demokratische Regierungs- oder Governancemodelle (Unternehmensverfassungen) gibt es? Modelle wie das von Isabell Ferreras und von Nell-Breuning gehen weit über die gegenwärtige Aufsichtsratsmitbestimmung hinaus. Ein wesentliches Ziel des Beitrages besteht darin, die Diskussion über die Frage der Unternehmensverfassung weiterzuführen und Debatten um Arbeitnehmer-Mitbestimmung, Corporate Governance, Unternehmenstheorie und Demokratietheorie miteinander in Beziehung zu setzen.
Emotionale Erfahrungen von Lehramtsstudierenden bei der Arbeit mit Eigenvideografien von Unterricht – Fallanalysen aus einer längsschnittlichen Interviewstudie im Praxissemester
Authors: Pollmeier Pascal , Rogge Tim , Vogelsang Christoph
Published: February 2022

Die Arbeit mit Videografien eigenen Unterrichts wird in Praxisphasen in der universitären Lehramtsausbildung zunehmend als methodisches Mittel zur Reflexion von Unterrichtserfahrungen genutzt. Als wesentlicher Einflussfaktor für einen erfolgreichen Einsatz werden dabei die begleitenden Emotionen der Studierenden angenommen. In einer längsschnittlichen Interviewstudie wurden daher die emotionalen Prozesse von 20 Lehramtsstudierenden bei der Arbeit mit Eigenvideografien in Begleitveranstaltungen des Praxissemesters untersucht. Dabei konnten drei Typen rekonstruiert werden, die prototypische emotionale Muster im Praxissemesterverlauf beschreiben, die durch die Valenz emotionaler Zustände bezüglich der Eigenvideografie zu Beginn und Ende des Praxissemesters charakterisiert werden können (negativ-positiv, positiv-positiv, negativ-negativ). Bei fallübergreifender Betrachtung konnten zudem zentrale Zusammenhänge zwischen Emotionen und Merkmalen des Videoeinsatzes identifiziert werden, wie die Vertrautheit mit Mitstudierenden, der Prozess der Aufnahmegenehmigung und Vorerfahrungen mit Eigenvideografie. Die Ergebnisse der Studie können zur Vermeidung intensiver negativer Emotionen bei der Nutzung videobasierter Reflexion eigenen Unterrichts beitragen und die Akzeptanz von Eigenvideografie zur eigenen Professionalisierung in der Lehrerbildung erhöhen.
Olfaction, Cognitive Impairment, and PET Biomarkers in Community-Dwelling Older Adults
Authors: Tian Qu , Bilgel Murat , Moghekar Abhay R. , Ferrucci Luigi , Resnick Susan M.
Published: February 2022

Background: Olfactory deficits are early features of preclinical Alzheimer’s disease (AD). Whether olfaction is associated with PET biomarkers among community-dwelling older adults is less clear. Objective: Investigate cross-sectional and longitudinal associations of olfaction with mild cognitive impairment (MCI) and amyloid-β (Aβ) and tau deposition. Methods: We analyzed 364 initially cognitively normal participants (58% women, 24% black) who had baseline olfaction data and subsequent cognitive assessments during an average 2.4-year. A subset of 129 had PET-PiB (Aβ) (n = 72 repeated) and 105 had 18F-flortaucipir (FTP)-PET (tau) (n = 44 repeated). Olfaction was measured using a 16-item Sniffin’ Sticks Odor Identification Test. The association of olfaction with incident MCI was examined using Cox regression. Associations with PiB-distribution volume ratio (DVR) and FTP-standardized uptake value ratio (SUVR) were examined using partial correlation. We tested whether PiB+/–status modified these associations. Analyses were adjusted for demographics and olfactory test version. Results: 17 (5%) participants developed MCI. Each unit lower odor identification score was associated with 22% higher risk of developing MCI (p = 0.04). In the PET subset, lower scores were associated with higher mean cortical DVR and DVR in orbitofrontal cortex (OFC), precuneus, and middle temporal gyrus (p≤0.04). The “olfaction*PiB+/–” interaction in OFC DVR was significant (p = 0.03), indicating the association was limited to PiB positive individuals. Greater decline in odor identification score was associated with greater increase in anterior OFC DVR and entorhinal tau SUVR (p≤0.03). Conclusion: Among community-dwelling older adults, poorer olfaction predicts incident MCI and is associated with overall and regional Aβ. Greater olfaction decline is associated with faster Aβ and tau accumulation in olfaction-related regions. Whether olfaction predicts AD-related neurodegenerative changes warrants further investigations.
The Association Between Standard Electrocardiography and Cerebral Small Vessel Disease in a Memory Clinic Study
Authors: Tanaka Tomotaka , Gyanwali Bibek , Villaraza Steven Gayoles , Saridin Francis N. , Vrooman Henri , Ihara Masafumi , Reilhac Anthonin , Chen Christopher L.H. , Hilal Saima
Published: February 2022

Background: P-wave terminal force in lead V1 (PTFV1) on electrocardiography has been associated with atrial fibrillation and ischemic stroke. Objective: To investigate whether PTFV1 is associated with cerebral small vessel disease (CSVD) markers and etiological subtypes of cognitive impairment and dementia. Methods: Participants were recruited from ongoing memory clinic study between August 2010 to January 2019. All participants underwent physical and medical evaluation along with an electrocardiography and 3 T brain magnetic resonance imaging. Participants were classified as no cognitive impairment, cognitive impairment no dementia, vascular cognitive impairment no dementia, and dementia subtypes (Alzheimer’s disease and vascular dementia). Elevated PTFV1 was defined as > 4,000μV×ms and measured manually on ECG. Results: Of 408 participants, 78 (19.1%) had elevated PTFV1 (37 women [47%]; mean [SD] age, 73.8 [7.2] years). The participants with elevated PTFV1 had higher burden of lacunes, cerebral microbleeds (CMB), and cortical microinfarcts. As for the CMB location, persons with strictly deep CMB and mixed CMB had significantly higher PTFV1 than those with no CMB (p = 0.005, p = 0.007). Regardless of adjustment for cardiovascular risk factors and/or heart diseases, elevated PTFV1 was significantly associated with presence of CMB (odds ratio, 2.26; 95% CI,1.33–3.91). Conclusion: Elevated PTFV1 was associated with CSVD, especially deep CMB. PTFV1 in vascular dementia was also higher compared to Alzheimer’s disease. Thus, PTFV1 might be a potential surrogate marker of brain-heart connection and vascular brain damage.
BACE1 Overexpression Reduces SH-SY5Y Cell Viability Through a Mechanism Distinct from Amyloid-β Peptide Accumulation: Beta Prime-Mediated Competitive Depletion of sAβPPα
Authors: Owens Lauren , Bracewell Joshua , Benedetto Alexandre , Dawson Neil , Gaffney Christopher , Parkin Edward
Published: February 2022

Background: The Alzheimer’s disease (AD)-associated amyloid-beta protein precursor (AβPP) can be cleaved by β-site AβPP cleaving enzyme 1 (BACE1) and the γ-secretase complex to yield neurotoxic amyloid-β (Aβ) peptides. However, AβPP can also be cleaved in a ‘non-amyloidogenic’ manner either by α-secretase to produce soluble AβPP alpha (sAβPPα) (a fragment with neuroprotective/neurogenic functions) or through alternative BACE1-mediated ‘beta prime’ activity yielding soluble AβPP beta prime (sAβPPβ’). Objective: To determine whether sAβPPα depletion, as opposed to Aβ peptide accumulation, contributes to cytotoxicity in AD-relevant SH-SY5Y neuroblastoma cell models. Methods: AβPP proteolysis was characterized by immunoblotting in mock-, wild-type AβPP (wtAβPP)-, BACE1-, and Swedish mutant AβPP (SweAβPP)-transfected cells. AβPP beta prime cleavage was confirmed through secretase inhibitor studies and C-terminal fragment analysis. The roles of sAβPPα and sAβPPβ’ in cell viability were confirmed by overexpression studies. Results: Despite producing enhanced Aβ peptide levels, wtAβPP- and SweAβPP-transfected cells did not exhibit reduced viability whereas BACE1-transfected cells did. sAβPPα generation in SH-SY5Y-BACE1 cells was virtually ablated in lieu of BACE1-mediated sAβPPβ’ production. sAβPPα overexpression in SH-SY5Y-BACE1 cells restored viability whereas sAβPPβ’ overexpression decreased viability further. The anti-AβPP 6E10 antibody was shown to cross-react with sAβPPβ’. Conclusion: sAβPPα depletion and/or sAβPPβ’ accumulation, but not elevated Aβ peptide levels, represent the cytotoxic mechanism following BACE1 overexpression in SH-SY5Y cells. These data support the novel concept that competitive sAβPPα depletion by BACE1 beta prime activity might contribute to AD. The cross-reactivity of 6E10 with AβPPβ’also questions whether previous studies assessing sAβPPα as a biomarker using this antibody should be revisited.
Ambika approach for solving matrix games with payoffs of single-valued trapezoidal neutrosophic numbers
Authors: Brikaa M.G. , Zheng Zhoushun , Dagestani Abd Alwahed , Ammar El-Saeed , AlNemer Ghada , Zakarya M.
Published: February 2022

The principal objective of this article is to develop an effective approach to solve matrix games with payoffs of single-valued trapezoidal neutrosophic numbers (SVTNNs). In this approach, the concepts and suitable ranking function of SVTNNs are defined. Hereby, the optimal strategies and game values for both players can be determined by solving the parameterized mathematical programming problems, which are obtained from two novel auxiliary SVTNNs programming problems based on the proposed Ambika approach. In this approach, it is verified that any matrix game with SVTNN payoffs always has a SVTNN game value. Moreover, an application example is examined to verify the effectiveness and superiority of the developed algorithm. Finally, a comparison analysis between the proposed and the existing approaches is conducted to expose the advantages of our work.
Influence of wheelchair type on Wheelchair Propulsion Test performance in community-dwelling, adult wheelchair users1
Authors: Andrews Addison Williams , Vallabhajosula Srikant , Ramsey Crystal , Francis Jhonelle , Jaffe Whitney
Published: February 2022

BACKGROUND: The clinimetric properties of the Wheelchair Propulsion Test (WPT) have not been developed thoroughly. OBJECTIVE: To determine inter-rater reliability and reference values for the Wheelchair Propulsion Test (WPT) for active wheelchair users and to compare WPT performance between various types of manual wheelchairs at different paces. METHODS: This was a cross-sectional, descriptive study. Participants propelled a manual wheelchair 10 m while time and the number of pushes were recorded. Trials were performed in three different manual wheelchairs (a lightweight wheelchair (LW), an ultralightweight wheelchair (ULW), and the participant’s personal, customized wheelchair) at a comfortable pace and a fast pace. RESULTS: The ICC values ranged from 0.861 to 0.999 for both speed and number of pushes. Comfortable wheelchair propulsion speed ranged from 1.51 (0.31) m/s to 1.65 (0.33) m/s depending on the wheelchair utilized. Across both pace conditions, participants were significantly faster when using their personal wheelchair compared to the ULW (P < 0.001) and LW (P < 0.001). Push frequency was significantly greater during the fast pace condition compared to the comfortable pace condition (P < 0.001). CONCLUSIONS: Reference values for the WPT in active wheelchair users have been identified. Participants who utilize their personal wheelchair demonstrate faster wheelchair propulsion speeds complemented by greater push frequencies.
Physician recommended school accommodations and student outcomes following a mild traumatic brain injury among youth with persistent post-concussive symptoms
Authors: Takagi-Stewart Julian , Johnson Ashleigh M. , Smith Mallory B. , Wang Jin , Marcynyszyn Lyscha A. , Zatzick Douglas F. , McCarty Carolyn A. , Rivara Frederick P. , Vavilala Monica S.
Published: February 2022

BACKGROUND: Post-concussion return-to-learn (RTL) guidelines include implementation of school accommodations. Yet, little is known about physician recommendations for school accommodations and their impact, particularly among youth experiencing persistent post-concussive symptoms (PPCS). OBJECTIVE: We examined the association between physician recommended school accommodations and student outcomes among youth experiencing PPCS. METHODS: Data from a randomized comparative effectiveness trial was used. Physician recommended school accommodations (≤90 days post-injury) were collected via chart abstraction. Grade point average was extracted from school records. Reports of problems at school, concussion symptoms, health-related quality of life (HRQOL), anxiety symptoms, and depressive symptoms were collected by survey (at baseline, three months, and 12 months post study entry). RESULTS: Of 200 participants (Mage = 14.7, 62% female), 86% were recommended school accommodations. Number of recommended school accommodations was positively associated with number of school problems at three months (aRR 1.18, 95% CI:1.12–1.24) and 12 months (aRR 1.11, 95% CI:1.05–1.18). No significant associations were found between recommended school accommodations and GPA, HRQOL, anxiety symptoms, or depressive symptoms. CONCLUSIONS: Physicians recommend more school accommodations for students experiencing more school problems post-concussion. Appropriate implementation of RTL recommendations made by physicians by fostering partnerships among physicians, students, and schools may be needed to achieve student-centered RTL.
The programme of advanced training of scientific and pedagogical workers in the specialty - 014. Secondary education: natural sciences
Authors:   Institute of Pedagogy of the National Academy of Educational Sciences of Ukraine, Topuzov Oleg , Zabolotna Oksana ,   Institute of Pedagogy of the National Academy of Educational Sciences of Ukraine, Lokshyna Olena ,   Institute of Pedagogy of the National Academy of Educational Sciences of Ukraine, Kalinina Luidmyla ,   Institute of Pedagogy of the National Academy of Educational Sciences of Ukraine, Vasylieva Daryna ,   Institute of Pedagogy of the National Academy of Educational Sciences of Ukraine
Published: February 2022

The programme of advanced training of scientific and pedagogical workers is intended for their professional development in accordance with the state policy in the field of education. The programme is based on the European strategy for the development of education and effective practices of the leading PISA countries in the EU to develop key competencies and basic skills for lifelong learning. The programme is focused on improving the performance of Ukrainian students
Avaliação Clínico-epidemiológica de Pacientes com Carcinoma de Células Escamosas Oral
Authors: Santos Júlio César Saraiva , Rocha Carlos Eduardo Moura Carvalho , Costa Rafael Everton Assunção Ribeiro da , Pinto Eduardo Salmito Soares , Almeida Ana Luisa Rios Barbosa de , Teles João Batista Mendes , Nogueira Luciana Tolstenko , Pinto Lucielma Salmito Soares
Published: February 2022

Introdução: O câncer bucal corresponde a cerca de 30% de todos os tumores de cabeça e pescoço. Aproximadamente 90% dessas neoplasias malignas são carcinomas espinocelulares (CEC) e cerca de 15 mil casos novos são estimados a cada ano no Brasil. Objetivo: Avaliar os aspectos clinico-epidemiológicos de pacientes com CEC oral. Método: Estudo observacional, com delineamento transversal, quantitativo e retrospectivo, a partir da análise de prontuários de pacientes com diagnostico histopatológico de CEC bucal atendidos em um centro de referência em Oncologia da Região Nordeste do Brasil. Variáveis clinicas e epidemiológicas foram coletadas e analisadas. A análise estatística foi realizada utilizando-se o teste de qui-quadrado (p≤0,05). Resultados: Entre os 298 prontuários avaliados, predominaram pacientes do sexo masculino (75,2%), com idade média de 60,4 anos, tabagistas e etilistas (62,0%). A queixa mais frequente foi a presença de ferida ou lesão na boca (61,1%), e o local mais comum foi a língua (62,1%). As variáveis clinicas revelaram estadiamento clinico avançado (III ou IV) em 76,4% dos pacientes. Entre os pacientes com idade até 50 anos, houve maior concentração de homens (p=0,015) e maior consumo de álcool do que entre os pacientes acima dos 50 anos (p=0,010). As demais variáveis não exibiram diferença estatística significante entre os grupos. Conclusão: As características clinico-epidemiológicas relacionadas ao CEC bucal devem ser consideradas para o planejamento de políticas públicas, a fim de prevenir novos casos e permitir a realização de diagnóstico precoce.
LEGAL ANALYSIS OF LAW MAKING ACTIVITIES CONCERNING IMPROVING THE MECHANISM OF APPLICATION OF LIFE IMPRISONMENT IN UKRAINE
Authors:   Academy of the State Penitentiary Service, Chernihiv, Ukraine, Melnychenko І.P. , Parminskyi V.V. ,   Academy of the State Penitentiary Service, Chernihiv, Ukraine, Pekhovskyi A.Yu. ,   Main Department of Property and Resources,  Ministry of Defence Ukraine, Kyiv, Ukraine
Published: February 2022

Legal analysis of bills aimed at improving the mechanism of application of life imprisonment in Ukraine, namely: “On Amendments to Certain Legislative Acts Implementing Decisions of the European Court of Human Rights” № 4048 and “On Amendments to the Code of Ukraine on Administrative Offenses, the Criminal Code of Ukraine and the Criminal Procedural Code of Ukraine on the execution of decisions of the European Court of Human Rights” № 4049 is provided in the article. It is determined that the mechanism of parole in the form of life imprisonment proposed by these bills consists of two stages: the first stage is the replacement of life imprisonment with a milder punishment under the rules of the new version of Article 82 of the Criminal Code of Ukraine; the second stage is conditional early release from serving a sentence in the form of imprisonment, which is assigned to a convict in order to replace life sentence with a milder punishment (imprisonment) under the rules of a new version of Article 81 of the Criminal Code of Ukraine. The legal positions of the Committee on Ukraine’s Integration with the European Union, the Main Scientific and Expert Department of the Verkhovna Rada of Ukraine, and the expert assessment of the Council of Europe are analyzed. The generalized legal analysis of bills 4048, 4049 gave an opportunity to reveal their progressive provisions, as well as shortcomings. Progressive provisions of the bills include: convicts’ drawing up their personal plan for reintegration into society, a temporary restriction on re-applying for the replacement of life sentence with imprisonment for a definite term or a request for a parole. The shortcomings of the bills include: unjustifiably short minimum sentence that a convict must serve in order to be released from life sentence; lack of a mechanism for determining the risk assessment of those sentenced to life imprisonment; lack of legislation to provide for probation in the process of replacing life sentence with a milder sentence and parole in terms of risk assessment, reintegration plan and monitoring compliance with court obligations; lack of criteria for determining the risk of re-offending; implementation of administrative supervision by police bodies over persons released on parole; lack of clear content of the reintegration plan; providing conclusions of the administration of a penal institution on convict’s preparing for release. Key words: bill 4048, bill 4049, life sentence, parole, European standards, implementation.
CLASSIFICATION OF STAGES IN JUDICIAL PROCEEDINGS
Authors:   Academy of the State Penitentiary Service, Chernihiv, Ukraine, Olefir L.I. , Borysenko A.A.
Published: February 2022

The article highlights the concept and essence of the judicial proceedings stages. The specific features of the proceedings stages in terms of their legal nature, functional purpose and their place in system of criminal proceedings are revealed. The correlative communications with other stages of criminal trial is proved. The article is based on the analysis of scientific sources, domestic legislation, generalization of the practice of applying legal requirements and scientific knowledge. It is found out that all stages of criminal process are considered as interactive and separate parts of criminal procedural activities that can be characterized by certain features of criminal procedural form. It is defined that features of judicial proceedings stages include range of persons, series of procedural activities and procedural decisions. Every stage is separated from one another by the final procedural decisions, which divide the previous stage from the next one, complete implementation of procedural activities specific for earlier stage and afford an opportunity to conduct following procedural activities. The article also provides an overview of the classification of judicial proceedings stages. The analysis of scientific and legal literature reveals that the procedure of bringing a person to criminal responsibility is be considered as a stage of a criminal prosecution instead of a stage of criminal proceedings. Summing up the results, it can be concluded that the system of criminal proceedings passes the following stages 1) pre-trial investigation; 2) preliminary proceeding; 3) judicial proceedings; 4) proceedings in the court of appeal; 5) execution of court decision; 6) proceedings in the court of cassation; 7) proceedings in the Supreme Court; 8) proceedings on newly discovered circumstances. Key words: stages, judicial proceedings, criminal proceedings, classification, procedural activities.
ПРОГРАМНЕ ЗАБЕЗПЕЧЕННЯ ДЛЯ ГАЛУЗІ РЕСТОРАННОГО ГОСПОДАРСТВА
Authors: Колесніченко С.Л. , Павловський С.М. , Поплавська С.О.
Published: February 2022

У статті розглянуто програми, що дозволяють автоматизувати технологічні процеси на підприємствах ресторанного господарства. Традиційно для розробки рецептури фірмових страв та страв превентивного і лікувально-профілактичного призначення необхідно застосовувати значну кількість рецептурних компонентів. Тому актуальним є використання інформаційних технологій та сучасного програмного забезпечення для полегшення технологічних розрахунків у процесі конструювання багатокомпонентних харчових систем із заданими властивостями: харчовою, енергетичною, біологічною цінністю та мінімальною собівартістю. Аналіз ринку прикладного програмного забезпечення для технологів ресторанного господарства розглянуто на прикладі програмного забезпечення MS Excel, «Експерт софт», «Шеф Експерт». Найбільший інтерес становлять програми: «Технолог-Кулінар», «Технолог-Кондитер», «Технолог-Пекар». Ці програми розроблені для впровадження елементів системи якості та безпеки на підприємствах ресторанного харчування. Кожна з цих програм дозволяє швидко й якісно розробляти нормативно-технологічну документацію за своєю спрямованістю та вчасно забезпечувати кожен етап технологічного процесу всією необхідною інформацією, що дає змогу реально управляти якістю продукції. Автоматизація технологічних процесів харчових виробництв гарантує поліпшення процесів виготовлення страв високої якості та мікробіологічної безпеки, сприяє конкурентоздатності підприємства. В разі прийняття рішення про використання прикладного програмного забезпечення необхідно зробити правильний вибір та придбати гідну систему автоматизації. Обираючи прикладне програмне забезпечення, варто визначити, який саме функціонал потрібен конкретному підприємству. Також необхідно враховувати і важливий ціновий критерій у разі відповідного придбання програмного забезпечення, витрати на його встановлення та подальше обслуговування.
УДОСКОНАЛЕНИЙ АЛГОРИТМ ПРОВЕДЕННЯ ІНТЕРАКТИВНИХ ПРЕЗЕНТАЦІЙ ЗІ ЗВОРОТНОЮ КОМУНІКАЦІЄЮ
Authors: Савчук Т.О. , Руденко М.В.
Published: February 2022

Натепер інформація є найбільш цінним ресурсом у сучасному світі, є безліч способів донесення інформації до кінцевого користувача. Одним із таких способів є проведення презентацій. Зазвичай презентація – це набір слайдів, наповнених певною інформацією. Презентації проводяться перед певною аудиторією із залученням спікера, який своєю чергою доносить інформацію зі слайдів. Презентації проводяться у самих різних випадках і ситуаціях, від шкільних предметів до професійних зустрічей. Якість інформації, що буде донесена чи засвоєна слухачами, напряму залежить від виступу доповідача, але також досить важливим фактором є сам процес подання інформації. Основною проблемою будь-якої презентації є сухість та одноманітність презентації. Зазвичай доповідач створює наповнені текстом слайди та «читає» інформацію з них. Саме тому процес донесення інформації до користувачів потребує удосконалення, що своєю чергою визначає актуальність кваліфікаційної роботи. Одним з важливих етапів проведення інтерактивних презентацій є взаємодія з аудиторією, саме завдяки цьому забезпечується зв’язок доповідача та аудиторії. Зазвичай взаємодія забезпечується шляхом створення запитань до аудиторії. Це може бути опитування чи будь-яка інформація, яку потрібно донести до слухачів. Запропоновано удосконалений алгоритм проведення інтерактивних презентацій за рахунок можливості вибору режиму ідентифікації слухача презентації та використання інтерактивного опитування для покращення якості проведення презентацій. Запропонований функціонал допоможе збільшити кількість запитань від слухачів до оратора за рахунок анонімного режиму ідентифікації, а також допоможе доповідачам налагодити зворотний зв’язок з аудиторією за рахунок інтерактивного опитування, що загалом збільшить якість проведення виступів та презентацій.
Soekarno Hatta Airport Social Fund Application in PT. Angkasa Pura
Authors: Apriani Desy , Kusumawardhani Devi , Ma'ruf Yazid
Published: February 2022

The development of technology is currently growing rapidly so that many attract the attention of the wider community. The development of computers is constantly dynamic and requires information that is fast, precise and systematic and does not require a long time. Therefore, the processing of social funds plays a very important role in the financial process in the company. Social funds are gifts in the form of money provided or collected with the aim of helping the social needs of the company. Processing social funds still uses Ms. Excel is running less than the maximum due to input and expense input errors so that the report is out of sync. Therefore, there needs to be a social fund processing system to manage these funds to be synchronous. The research method used consisted of data collection methods, namely observation, interviews and literature study. For analysis using the PIECES analysis method. This system uses the PHP programming language and MySQL database. The system design uses the design of the UML (Unified Modeling Language) model. The testing method used is the Blackbox Testing method. The results obtained from this study are a social fund processing application system that helps companies in terms of fund management
Big Data Analysis of Covid-19 Spread Based on Distribution Map and Protocol Regulations with Business Intelligence
Authors: Sinaga Anita Sindar , Sitio Arjon Samuel
Published: February 2022

Various parties analyze the total cases of the Corona virus every day to prevent a high level of spread. Big Data technology involves data that is diverse, rapidly changing, super large in size so that conventional technology cannot be handled effectively. Four stages of processing Big Data until the output it produces is information for users, namely acquired, accessed, analytics, and application. Business Intelligence serves to transform operational, transactional data into useful information within the company. Big Data Analytics analyzes information, IDE for current and past business decisions visualized in graphical form. The problem in this study is modeled in the Big Data architecture with the aim of comparing the trend of the spread of Covid-19 related to process regulation. Based on the distribution map data and the regulation of health protocol rules with various online data sources, structured and unstructured using Business Intelligence (BI) cleaning data, three patterns of spread of the corona virus were found, High Cases, Medium Cases and Low Cases from 34 provinces throughout Indonesia. West Java Province became the first order of the highest cases during May 2021 with an average case of 21% followed by DKI Jakarta 14%.
Turn On Light Raspberry Pi To Reduce Traffic Jam
Authors: Rafika Ageng Setiani , Kusumah Hendra , Septiawati Mayang
Published: February 2022

Nowadays human and computer communication has changed from time to time. The change is aimed at making communication between humans and computers more efficient. Human needs for information and communication are increasing with digital communication, the microcontroller used is Raspberry Pi 3. The traffic conditions are very congested, using a manual system does not work optimally due to the number of undisciplined road users and the increasing amount of volume vehicles every year. Therefore it is very necessary that the LEDs are turned on to reduce the volume density of the vehicle, especially at the intersection, and can control the time of the traffic lights in accordance with the specified time. Internet of Things (IoT) uses Raspberry Pi 3, ESP8266 Wi-fi Module, Sensor RCWL 0516 and Blynk. Raspberry Pi 3 as the main controller uses wireless networks, and makes devices able to communication such as sending and receiving data. The Blynk application is able to provide information in real time as well as remote control monitoring. When the sensor detects, the ESP8266 Wi-fi Module will send traffic density notifications via Smartphone so that it can provide information on road conditions periodically. The purpose of this study is to monitor the condition of the road from a distance so that road users are disciplined in driving and do not commit violations when the red light is on.