bluuebunny/crossref_metadata_2025 huggingface dataset:
Cantinas Survey: proposição e avaliação de um aplicativo para análise do risco sanitário e dos alimentos comercializados em cantinas escolares
Authors: Balestrin Mariana , Brasil Carla Cristina Bauermann , Bellei Ericles Andrei , Marchi Ana Carolina Bertoletti De , Kirsten Vanessa Ramos , Wagner Mario Bernardes
Published: September 2022

Este artigo revela um estudo que tem por objetivo apresentar a versão inicial do desenvolvimento tecnológico e a avaliação de um aplicativo móvel que auxilia a coleta de dados, análise, avaliação e o monitoramento das cantinas escolares saudáveis. O desenvolvimento do aplicativo aconteceu em etapas, com a definição dos eixos de investigação, avaliação por especialistas, adaptação, aplicação prática em 27 cantinas escolares e avaliação da usabilidade, percepção e aceitação pelos usuários finais. O aplicativo, desenvolvido para o sistema operacional Android, é dividido em três partes: caracterização do perfil da cantina escolar; avaliação do risco sanitário; e características dos alimentos comercializados. Ele apresentou uma usabilidade satisfatória no que diz respeito aos critérios de efetividade, eficiência e satisfação do usuário. Entre os principais benefícios, destacam-se a maior agilidade de coleta, processamento e análise de dados, a facilidade de uso, a padronização dos procedimentos e vantagens econômicas de contribuir para a sustentabilidade ambiental. Trabalhos futuros envolverão melhoria de suas funcionalidades e disponibilização de uma versão pública.
Meio ambiente e saúde: caminhos para uma divulgação científica multidisciplinar?
Authors: Oliveira Denise Maria de , Vasconcelos Wagner Robson Manso de
Published: September 2022

O trabalho que fundamenta este artigo traçou dois caminhos metodológicos para analisar a divulgação científica sobre a relação entre desmatamento, mudanças climáticas e saúde em uma experiência selecionada. Foi realizada revisão de literatura para identificar como o tema emergia em artigos científicos publicados no Brasil entre 2020 e 2021. A partir do referencial temático identificado por meio de palavras-chave, foram analisados 42 vídeos publicados pelo canal Ciência com Certeza no YouTube. Considerando os conceitos de divulgação científica e comunicação científica segundo Bueno (2010), é possível afirmar que o projeto caracteriza-se como de comunicação científica extrapares por estar direcionado ao público especializado de diversas áreas do conhecimento. A disponibilização pública das gravações das palestras não o caracteriza como um projeto de divulgação científica, embora tenha potencial de ampliar seu direcionamento para públicos leigos. Também foi constatado que a relação entre meio ambiente e saúde não foi tema central das palestras no período analisado.
Vida saudável? Os discursos construídos no Instagram pelo médico Mohamad Barakat
Authors: Lima Lunélia Amaral , Souza Flávia Mayer dos Santos
Published: September 2022

Em meio ao crescimento da participação de médicos nas mídias sociais digitais, este artigo objetiva analisar os discursos sobre vida saudável produzidos no Instagram pelo médico Mohamad Barakat (@doutorbarakat). O corpus é composto por stories selecionados a partir de uma coleta diária realizada ao longo de três meses em 2020. Como referencial teórico-metodológico recorre-se à semiótica discursiva e à semiótica plástica. Os resultados apontam a construção do discurso de vida saudável revestido por temas como rotina, estilo de vida, comportamento, aconselhamento e autocuidado, figurativizados por elementos de comprovação e reforçados pelo arranjo expressivo, em que a presença do médico é marcada por informalidade, intimidade e proximidade. Uma concepção de vida saudável que dialoga com a otimização de si discutida por Paula Sibilia e Marianna Ferreira Jorge e com a busca da aptidão levantada por Zygmunt Bauman.
Length-Weight and Length-Length Relationships and Condition Factor of An Endemic Fish Species (Capoeta tinca (Heckel, 1843)) Inhabiting Bayat Pond (Ankara, TÜRKİYE))
Authors: YAZICI Ramazan , SAYLAR Ömer
Published: September 2022

The aim of this study is to determine the length-weight relationship, length-length relationship, and Fulton’s condition factor (K) of Capoeta tinca, which is endemic to Turkey. A total of 52 samples were obtained from Bayat Pond in 2017. The total length (TL) of the samples ranged between 20 and 34 cm. Total weights (W) of they also varied from 85 to 446g. Strong correlations were found between length and weight. In the length-weight relationship equation, a and b was found as 0.0144 and 2.9028, respectively. b value was not statistically different from 3 (t-test, P>0.05). Therefore, this species showed isometric growth in the Bayat Pond. The value of Fulton’s condition factor was 1.0485. Total length - Fork length (FL), Total Length - Standard length (SL) and Fork length - Standard length conversion equations were calculated. There was a high correlation between all length types. In this study, the length-weight relationship, length-length relationship, and Fulton's condition factor values of Capoeta tinca inhabiting Bayat Pond were determined for the first time.
Evaluation of the Therapeutic Potential of Warburgia ugandensis, Prunus africana, and Piliostigma thonningii against Leishmania donovani in vitro and in Balb/c Mice
Authors: Mogaka Maria Divinah , Mutiso Joshua M. , Macharia John C. , Ayako Rebecca M. , Osero Bernard , Gicheru Michael M.
Published: September 2022

Leishmaniasis is a zoonotic disease caused by protozoan parasites of the genus Leishmania. Conventional chemotherapy remains to be the most preferred measure against leishmaniasis despite being associated with high toxicity and relapse rates. They are also expensive and require hospitalization. Plant-based compounds provide a better treatment alternative because they are effective, cheap, and less associated with toxicity and resistance. This study examined the therapeutic potential of Warburgia ugandensis, Prunus africana, and Piliostigma thonningii against Leishmania donovani infection in BALB/c mice. Anti-promastigote and toxicity studies were evaluated by incubating the test compound with promastigotes and Vero cells, respectively. Serum was obtained from the mice for total immunoglobulin gamma (IgG) quantification. For in vivo studies, the mice were infected with virulent Leishmania donovani then treated with methanolic extracts of Warburgia ugandensis, Prunus africana, and Piliostigma thonningii and control drug, pentostam (sodium stibogluconate). Treatment with the plant extracts and standard drug resulted to significant reduction in parasite burden. Outcomes in the mice treated with plant extracts were comparable to those treated with pentostam (P≥0.05). In the promastigote assay, all the test compounds killed more than half of the promastigotes at the highest concentration (500 µg/mL). Warburgia ugandensis, P. thonningii, and P. africana reduced the number of promastigotes from 2.0 × 106 to 7.7 × 103 , 72.0 × 103 , and 5.0 × 103 , respectively. Pentostam had the lowest IC50 (210 µg/mL), followed by Warburgia ugandensis (IC50 of 270 µg/mL). Piliostigma thonningii and P. africana were less toxic with IC50 of 720 µg/mL and 500 µg/mL, respectively. There was low production of IgG antibodies following treatment with the plant extracts and high levels in the untreated control.
The effect of water hyacinth (Eichhornia crassipes) organic fertilizer on the vegetative growth of Manado strain yellow maize (Zea mays L.)
Authors: Merry Gosal  , Debby Rayer  , Sukmarayu Gedoan
Published: September 2022

Introduction: The invasion of water hyacinth (Eichhornia crassipes), a freshwater weed, has been an unsolved problem in many lakes around the world, including in Tondano lake, Indonesia. Since the 2000s, many efforts to eliminate it have turned unsuccessful and uneconomical. Here, we aim to provide a solution and perform a systematic study to utilize water hyacinth as an organic fertilizer for application to local crops, the Manado strain yellow maize. Methods: Water hyacinth was manually harvested and fermented using an effective microbial fermentation for one month. The resulting compost was analyzed chemically and applied to bedding groups of maize at increasing doses: 0, 100, 150, 200, and 250 grams per plant. All beddings were made in triplicate, consisting of 8-10 plants per repeat. At 2 and 12 weeks post plantation, a series of measurements of plant height, leaf length, and leaf width was performed. Data were analyzed using one- or two-way ANOVA. Results: The application of water hyacinth organic fertilizer had readily shown beneficial effects on vegetative growth at 2 weeks of age in terms of plant height, leaves length and leaves width at the dose of 200 and 250 grams of fertilizer per plant. This effect persisted up to 12 weeks of age in terms of plant height, but not in leaves length or width. Conclusion: The application of water hyacinth organic fertilizer is able to increase the vegetative growth of the local Manado strain of yellow maize at the dose of 200 grams per plant.
Roles of soluble TAM receptors, ligands for these receptors, and shedding enzymes in patients with acute pancreatitis
Authors: Soichiro Uehara  , Yuichi Fukuzawa  , Tomohiko Matuyama  , Katshuhiro Gotoh
Published: September 2022

The goal of the study was to measure the plasma levels of soluble TAM receptors (sTAMRs: Tyro3, Axl and Mer), growth arrest-specific 6 (Gas6), free-PROS1 (Protein S), and C4bp-protein and two disintegrin metallopeptidase domains (ADAM 10 and 17) in patients with acute pancreatitis (AP). The subjects were 56 patients, including 14 cases of severe AP and 42 cases of mild AP, and 20 healthy normal controls. Plasma levels of the three sTAMRs, Gas6, free PROS1 and C4bp-protein, and two ADAMs were measured using ELISA kits. The levels of the sTAMRs and ADAM10 and 17 increased markedly with greater severity of AP. Three sTAMRs increase rate became the order of sTyro3, sMer and sAxl, while ADAM10 was higher than ADAM17. The platelet count and PROS1 significantly decreased in AP but there are differences between C4bp-protein, but these are not significant. sTAMRs levels increased in the early stage in almost all AP patients, but then gradually normalized. However, sTAMRs in non-survivors increased again in the late stage. The fluctuations of ligands (Gas6 and free-PROS1) levels in AP patients showed progress like three sTAMRs.　The correlation coefficients of sTAMRs with ligands were stronger for free-PROS1 in non-survivors and patients with severe AP, whereas Gas6 was more strongly correlated with sTAMRs in patients with mild AP. Marked increases of sTAMRs and ADAMs were found with increased severity of AP. Gas6 and free-PROS1 in the TAM system may have complementary roles in local and systemic lesions, respectively.
İBN EBÎ ZEYD EL-KAYRAVÂNÎ VE KELÂM ANLAYIŞI
Authors: FİDANBOY Ömer
Published: September 2022

İbn Ebî Zeyd el-Kayravânî (ö. 386/996), İslâm düşüncesinde fikrî ayrılıkların yaşandığı, mezhepler arası fikir çatışmalarının cereyan ettiği ve sosyo-politik açıdan zor şartların hüküm sürdüğü bir dönemde (h. IV y.y.) ve kritik bir coğrafyada (Kuzey Afrika) yaşamış, Mâlikî mezhebine mensup önemli bir düşünürdür. O, Mu‘tezilî, Mürciî, Haricî, Şi‘î ve diğer düşünce akımlarına karşı Selef akidesinin metodunu benimsemiş, Mâlikî mezhebini savunmuş, mezhebin yayılmasına katkıda bulunmuş ve Ehl-i Sünnet düşüncesinin sonraki nesillere aktarımında önemli bir rol oynamıştır. Ancak mezkûr düşünce akımlarına karşı kullandığı Selef metodunun yetersiz kaldığının farkına varan Kayravânî, kendisi gibi Mâlikî fıkhına mensup olan Ebü’l-Hasan el-Eş‘arî’nin (ö. 324/935-36) bu tür akımlara karşı verdiği mücadeleyi yerinde bulup takdir etmiştir. Kayravânî’nin Eş‘arî’ye olan bu sempatisi onun Eş‘arî’den etkilenmesini kaçınılmaz kılmıştır. Çalışmada İbn Ebî Zeyd el-Kayravânî’nin er-Risâle ve el-Câmi‘ adlı eserleri özelinde kelâmî görüşleri ele alınmıştır. Ayrıca Selefî ve Eş‘arî ithamları arasındaki Kayravânî’nin tutumu, konumunu ve benimsediği metot ortaya konulmaya çalışılmıştır.
KAYGIYLA BAŞA ÇIKMADA İNŞİRÂH/HİSLERİ GENİŞLETME: KURAMSAL BİR MODEL DENEMESİ
Authors: YAPICI Asım , KAYIKLIK Hasan
Published: September 2022

Bu çalışmada, zor yaşam olaylarına maruz kalan bir insanın yaşadığı kaygıyla başa çıkabilmesinde, “Kur’an temelli inşirâh (hisleri genişletme) kavramı üzerinden yerel bir model önerilebilir mi?” sorusuna cevap aranmaktadır. Amacı ise “Biz senin göğsümü genişletmedik mi?” (İnşirah suresi, 1) ayetine dayanarak yaşanan psikolojik sorunlara karşı algı ve hisleri genişletmenin işlevsel değerini ortaya koymak, buradan hareketle bilim dünyasına evrenselle yereli harmanlayan, Doğu bilgeliğiyle Batının bilimselliğini iç içe sokan kuramsal bir model denemesi sunmaktır. Veriler literatür taramasına dayalı olarak toplanmış, betimsel analiz tekniğiyle çözümlenmiştir. Kaynaklardan edinilen bilgilere göre inkıta-ı vahiy (vahyin bir müddet kesilmesi hadisesi) yaşadığı dönemde iç ve dış faktörlerin etkisiyle kaygı ve endişe düzeyi ziyadesiyle yükselen Hz. Peygamber, zihinsel ve duygusal açıdan sıkıntılı günler geçirmiştir. Bununla birlikte o, Duhâ suresinin nüzulü ile kendisini rahatsız eden duygu ve düşüncelerden (kaygı halinden) kurtulmuştur. İnşirah suresinde ise Hz. Peygamberin yaşadığı sıkıntılı hallerden neden ve nasıl kurtulduğuna yönelik psikolojik izahlar mevcuttur. Duhâ ve İnşirâh surelerinde vurgulanan hususları çözümleyecek ve günümüz kavramlarıyla ifade edecek olursak şu tespiti yapabiliriz: Her iki surenin nüzul sebebi, anlamı ve verdiği mesajlar; kısmen bilişsel davranışçı, kısmen fenomenolojik, kısmen varoluşçu danışma kuramları kapsamında değerlendirilebilecek özgün bir model içermektedir. Ancak vurgulamak gerekir ki söz konusu özgünlük, Batılı yaklaşımların eklektik bir şekilde sunumundan değil İslam bilgi anlayışı ve insan modelinden kaynaklanmaktadır. “İnşirah” modelinde insan, kartezyen felsefeden mülhem bilinç-beden, şekil-öz, madde-mana, fizik-metafizik ayrımına tâbi değildir. Bu nedenle bahsi geçen çağdaş psikolojik danışma kuramları için “kısmen” ifadesi özellikle kullanılmıştır. Çünkü inşirah modelinde sadece bilişsel düzeyde yanlış ve mantıksız düşüncelerden kurtulmak değil göğsün genişle(til)mesi de önemlidir. Bu bağlamda, inşirâh ya da hisleri genişletme haline yönelik açıklamalar ve verilen örnekler, Kur’an-ı Kerim ve İslam kültürüne dayalıdır. Bununla birlikte önerilen model her ne kadar yerellik içerse de Batılı kuramlara bütünüyle ters değildir.
HANEFÎ KADISI TARSÛSÎ’NİN KİTÂBÜ’T-TEVÂRÎH’İNİN NUAYMÎ VE İBN TOLUN’UN BİYOGRAFİ ESERLERİNE KAYNAKLIĞI
Authors: SADIKER Ömer , AKBAŞ Hamdi
Published: September 2022

Mısır’ın Selâhaddin Eyyûbî (ö. 589/1193) tarafından fethinden (567/1171) sonra uygulamaya konulan Şâfiî kādılkudât tayini Memlükler’de daha geniş formuna kavuşmuştur. Memlükler’in ilk yıllarında Şâfiî kādılkudâtın yanına görevinde yardımcı olmak üzere diğer mezheplerden naibler atanmıştır. Şâfiî merkezli yargı sisteminin anlaşmazlıklara yol açması üzerine I. Baybars’ın emriyle sadece Şâfiîlerden bir kādılkudât tayin edilmesi uygulamasından vazgeçilmiş önce başşehir Kahire olmak üzere tedricen diğer şehirlerde de icra edilmek üzere dört sünnî mezhebin mensuplarına kendi mezheplerine göre hükmedecek kādılkudâtlar tayin edilmiştir. Uygulama bölgelerde mezhep mensubu âlimlerin, müderrislerin yetişmesinin önünü açmış, buralardan devlet kademesinde görev alan tarihe mâl olmuş ilim adamları yetişmiş ve tarihi kayıt altına alan müverrihler meşhur ilim adamlarının biyografilerini kaleme almıştır. Nuaymî ve öğrencisi İbn Tolun, Memlük dönemi tarihçilerinin öne çıkan şahsiyetleri arasındadır. Bunların biyografi eserlerinde istifade ettiği kaynaklardan biri de Hanefîler ile Eşʽarîler arasındaki görüş ayrılıklarını manzum bir şekilde ilk defa ele alan ve hilafette Kureyşli olmanın şart olmadığını dile getiren Necmeddin Tarsûsî’nin Kitâbü’t-Tevârîh’idir. Çalışmanın konusu Kitâbü’t-Tevârîh’in Nuaymî’nin ed-Dâris fî Târîhi’l-Medâris’i ile İbn Tolun’un Kudâtü Dımaşk ve el-Kalâidü’l-Cevheriyye adlı eserlerine kaynaklığıdır. Amacı, kaynaklarda Dımaşk tarihi olarak bilinen bu eserlere kısmen de olsa Kitâbü’t-Tevârîh’in kaynaklığını ortaya koymak, örnekleri ve delilleriyle ispat etmektir. Yöntemi ise ilgili eserleri içerik ve metin açısından karşılaştırma yöntemidir. Bu üç eserin ikisinde müelliflerin atıfta bulunmaları sebebiyle Kitâbü’t-Tevârîh’in kaynaklığını ifade ettikleri görülür. Herhangi bir atfın yapılmadığı Kudâtü Dımaşk’ta ise ikisi arasındaki yoğun benzerlikler sebebiyle Kitâbü’t-Tevârîh’in bu esere de kaynaklık ettiğini dile getirmek bilimsel bir zorunluluktur.
The Clinical Effect of Dapagliflozin in Patients with Angiographically Confirmed Coronary Artery Disease and Concomitant Type 2 Diabetes Mellitus
Authors: Dzhun Yana Yu. , Marushko Yevhen Yu. , Saienko Yanina A. , Rudenko Nadiya M. , Mankovsky Borys M.
Published: September 2022

Nowadays treatment of patients with coronary artery disease (CAD) and concomitant type 2 diabetes mellitus (DM) needs further study.

The aim. Evaluation of the clinical effect and glycemic variability of dapagliflozin in patients with angiographically confirmed CAD and concomitant type 2 DM.

Materials and methods. The study involved 47 patients with angiographically confirmed CAD. The patients underwent laboratory blood tests, electrocardiography, echocardiography, continuous glucose monitoring and percutaneous coronary intervention (PCI). Depending on the usage of dapagliflozin 10 mg, the patients were divided into 2 groups: group I (+SGLT2i, n = 24) and group II (–SGLT2i, n = 23). The average follow-up period was 16 months.

Results. Distribution of the examined patients by age, anthropometric characteristics, duration of DM, functional state of the heart and kidneys, smoking, the presence of acute cardiovascular events and previous PCI showed no statistically significant difference. In patients of group I, on the background of taking SGLT2i, a decrease in body mass index and improved glycemic profile were revealed. Patients in group II were more likely to have complaints of angina (4 [17.3%] vs 1 [4.3%], p>0.05); repeated coronary angiography in this group was significantly more likely to reveal progression to atherosclerotic CAD (4 [17.3%], p<0.05) which required re-revascularization. No fatalities were detected during the follow-up.

Conclusion. Dapagliflozin has improved glycemic and lipid profile of the blood and long-term prognosis after PCI. Adding this drug to the treatment reduces the clinical progression of CAD, the need for re-hospitalization and cardiac revascularization.
Prenatal Diagnosis of Chromosome 22q11.21 Microduplication Syndrome in a Fetus with Congenital Malformation of the Cardiovascular System: Case Report
Authors: Galagan Vira O. , Dudierina Yuliia V. , Pavlova Anna O.
Published: September 2022

A clinical case of microduplication of chromosome 22q11.21 in a fetus with a malformation of the cardiovascular system (vascular ring) is presented. This anatomical variant of the vascular ring is extremely rare and is formed by the pathological circumflex retroesophageal left-sided cervical aortic arch with the left arterial ductus arteriosus. The anatomical features of the circumflex cervical aortic arch are the left-sided pathological curved aortic arch in combination with the right-sided descending aorta. This vascular pathology can cause compression of the trachea and esophagus. This variant of the vascular ring is extremely unfavorable for surgical correction. Chromosome 22q11.21 microduplication syndrome is associated with the clinical presentation of “cat eye syndrome”. The clinical case description shows unique data from instrumental and genetic studies. All stages of examination of a pregnant woman from primary to tertiary medical care are described. The features and importance of a multidisciplinary approach are also presented.

Every case of congenital heart defect in fetus, confirmed by echocardiographic method in a specialized institution, requires medical and genetic counseling. Using of the highly sensitive specific molecular cytogenetic method, comparative genomic hybridization, in prenatal diagnosis allows for timely diagnosis of microstructural disorders of chromosomes in fetus. Follow-up of a pregnant woman with congenital heart defect in the fetus requires a multidisciplinary approach not only to improve diagnosis and treatment, but also to calculate genetic risk.
Myocardial Revascularization in Patients with Coronary Artery Disease and Reduced Left Ventricular Ejection Fraction
Authors: Kucheriava Mariia V. , Mankovsky Georgiy B.
Published: September 2022

The aim. To evaluate the short-term and long-term outcomes of myocardial revascularization – percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) – in patients with coronary artery disease (CAD) and heart failure (HF) with reduced left ventricular ejection fraction.

Materials and methods. This one-center prospective study was conducted on the basis of the Ukrainian Children’s Cardiac Center, Clinic for Adults, Kyiv, Ukraine. Analysis included 194 patients with CAD and HF with reduced left ventricular ejection fraction. The studied cohort of patients underwent myocardial revascularization: 99 (51.1%) patients through PCI and 95 (48.9%) patients through CABG during 24 months (between January 2020 and January 2022).

Results and discussion. PCI and CAD were associated with a similar risk of all-cause mortality during 30-day follow-up (HR 0,95; [95% CI], 0.135-6.796; p=0.96). When analyzing the long-term results of myocardial revascularization in terms of the effect on all-cause mortality, PCI and CABG had identical results, no significant difference was observed (HR 1.05; [95% CI], 0.448-2.481; p = 0.903). However, PCI was associated with an increased risk of repeated myocardial revascularization (HR 3.00; [95% CI], 1.251-7.221; p=0.025) compared with CABG. Patients who underwent CABG had a significant difference in the number of re-hospitalizations due to HF progression compared to those after PCI (HR 0.33; [95% CI], 0.170-0.652; p=0.002). The rehabilitation period was 2±4 days in patients after PCI, and 7±4 days in patients after CABG, which corresponded to a statistically significant difference (HR 3.48; [95% CI], 2.489-4.891; p <0.001). The visual analog scale scores of pain intensity were 3±1 in patients after PCI and 7±2 in those after CABG, the difference is statistically significant (HR 3.16; [95% CI], 2.283-4.382; p <0.001).

Conclusions. Results of myocardial revascularization with PCI and CABG had identical short-term and long-term all-cause mortality rates. However, PCI was associated with a higher risk of repeated myocardial revascularization over a 2-year follow-up period. CABG, in turn, was associated with more frequent HF readmissions than PCI. The rehabilitation period was statistically shorter in patients after PCI. According to the visual analog scale, the pain in patients after CABG was more pronounced.
Cardiorenal Syndrome in Patients with Infective Endocarditis Complicated by Acute Heart Failure
Authors: Koltunova Hanna B. , Mazur Andriy P. , Krykunov Oleksii A. , Chyz Kostiantyn P. , Klymenko Larysa A.
Published: September 2022

Cardiorenal interaction in acute heart failure (AHF) is becoming an increasingly recognized factor to consider in the management of cardiac surgical patients. Achieving adequate control of water balance and simultaneously preserving kidney function is the goal of the optimal management strategy for patients with AHF. The majority of preoperative hospitalizations to intensive care units in patients with infective endocarditis (IE) are associated with the development of AHF. The term “cardiorenal syndrome” (CRS) is used to define kidney dysfunction on the background of AHF. Due to the lack of clear clinical manifestations of CRS in IE, the diagnosis and treatment of this pathology may be delayed and contribute to the increase in the number of postoperative complications. Recent data, both in basic science and in clinical research, have changed our understanding of CRS. To date, several types of impaired interaction between the kidneys and the heart have been identified.

The aim. To study the peculiarities of CRS in patients with IE complicated by AHF.

Materials and methods. The basis of this study was the clinical data of 41 patients with active IE who were treated at the National Amosov Institute of Cardiovascular Surgery of the National Academy of Medical Sciences of Ukraine from 1/1/2020 to 8/31/2020. In order to study the features of clinical manifestation and the course of CRS, a comparative analysis was conducted based on the history and results of laboratory and instrumental research for the group of patients with IE complicated by preoperative AHF, and patients without clinical manifestations of AHF at the time of hospitalization. For an in-depth study of myocardial damage in heart failure, troponin, NT-proBNP, lactate levels were analyzed; dysfunction of the urinary system was assessed by the level of urea and serum creatinine, the volume of diuresis.

Results. A reliable relationship between the levels of NT-proBNP and serum creatinine at the preoperative stage was revealed (p˂0.001), as an indicator of the presence of CRS in patients with IE. In the early postoperative period, signs of CRS persisted in patients with IE complicated by preoperative AHF (serum creatinine 157.0±8.5 μmol/l [p<0.001], NT-proBNP 8214.9±2390.0 pg/ml [p=0.010]). Normalization of kidney function indicators was reported on the day 14 after surgery.

Conclusions. Cardiac surgical intervention in patients with IE contributes to reduction of CRS manifestations on the day 14 of the postoperative period.
Diagnostic Features and Selection of Hypolipidemic Therapy in Patients with Coronary Artery Disease with “Possible” Familial Hypercholesterolemia
Authors: Mitchenko Olena I. , Timokhova Kateryna O. , Chulaievska Nataliia M.
Published: September 2022

The aim. To optimize the diagnostic algorithm for patients with true “possible” familial hypercholesterolemia (FH) and differential diagnosis with hypercholesterolemia on the background of comorbid endocrinopathies for selection of optimal hypolipidemic therapy.

Materials and methods. We examined 130 patients with hypercholesterolemia and comorbid pathology (type 2 diabetes mellitus, hypothyroidism, obesity grade II-III). In each group, subgroups with low-density lipoproteins (LDL) ≥5 mmol/l were selected and followed up on the background of maximum tolerated doses of statins in combination with therapy aimed to compensate comorbid pathology. The control group consisted of 20 patients with verified FH.

Results and discussion. Combined dyslipidemia was detected in groups 1 and 3, pure hypercholesterolemia in group 2. Direct correlations between lipid profile and comorbid pathology characteristics were revealed. Patients of the subgroups with “possible” FH had higher atherogenicity of the lipid profile associated with comorbid pathology destabilization and high percentage of atherosclerosis of carotid and coronary arteries. According to the results of the follow-up, it was established that statin therapy and comorbid pathology compensation led to the achievement of target levels of LDL (group 3) or a reduction of LDL by 50% (group 1, 2). In patients of the control group, statin therapy with maximally tolerated doses did not show such results.

Conclusions. The cohort of patients defined as having “possible” FH is heterogeneous and may include patients with secondary dyslipidemia on the background of comorbid pathology destabilization, timely verification and treatment of which contributes to achieving the goals of lipid-lowering therapy. Taking into account that only obese patients reached the target level of LDL <1.8 mmol/l, combined lipid-lowering therapy is recommended for patients with hypothyroidism and diabetes. Refractoriness to statin therapy in patients with verified “possible” FH emphasizes the need for combined lipid-lowering therapy (ezetimibe, PCSK9 inhibitors).
Awareness Among Otorhinolaryngologists of Literature Resources: Survey Research
Authors: ture Nurullah , tunc yesim , Aksoy Cemal
Published: September 2022

Amaç: Bu çalışmada, ulusal ölçekte kulak burun boğaz hekimleri arasında podcast farkındalığının ve kullanım sıklığının araştırılması amaçlanmıştır.
Hastalar ve Yöntem: Çevrimiçi anket türündeki çalışmamız, 2021-2022 yılları arasında ‘Google forms’ (Mountain View, CA) açık web adresi üzerinden yapılmıştır. Hedef kitle, ulusal ölçekteki her yaş ve deneyim seviyesinden kulak burun boğaz hekimleridir. Anketimiz yirmi sorudan oluşmaktadır.
Bulgular: Anket çalışmamızda, sorularımıza cevap veren kişi sayısı 112’dir. Bu 112 kişinin 92’ si erkek (%82,1), 20’ si kadın (%17,9)’dır. Kulak burun boğazla ilgili mesleki alanda podcast dinleyen %20,5 (n=23), dinlemeyen %79,5 (n=89) olarak izlendi. Pandemi öncesi en sık başvurulan kaynakların %40,2 (n=45) ile kitap ve %31,3 (n=35) ile e-kitap olurken, pandemide %30,4 (n=34) çevrimiçi toplantı ve %27,7 (n=31) e-kitap olduğu izlenmiştir. Pandemi öncesi ve pandemi dönemi başvurulan kaynakların sıklık karşılaştırılmasında istatistiksel anlamlı fark bulunmuştur (p<0,001).
Sonuç: Süregelen pandemi bilgi kaynaklarına başvuru sıklığını etkilemiş olmasına rağmen, podcast kullanımında anlamlı bir değişikliğe neden olmamıştır. Yazarlar, bu makalenin kulak burun boğaz alanında Türkçe podcast üretmek için bir farkındalık oluşturacağını umuyorlar.
Autologous Hematopoietic Stem Cell Transplantation in Pediatric Malignant Diseases: 12 Years of Experience
Authors: kartal Ibrahim , dagdemir ayhan , dincer oguz salih , elli murat , albayrak canan
Published: September 2022

Amaç: Bu çalışmada yüksek riskli pediatrik solid tümör hastalarında uyguladığımız otolog hematopoietik kök hücre tedavisinin (OHKHT) etkinlik ve güvenilirliğini 12 yıllık tecrübemizle paylaşmayı amaçladık. Hastalar ve Yöntem: Ocak 2009-Temmuz 2021 tarihleri arasında Çocuk Kemik İliği Nakil Ünitesi'nde 18 yaş altı OHKHT yapılan pediatrik maligniteli hastaların verileri retrospektif olarak değerlendirildi. Bulgular: Ortanca yaşı 7,8 (0,5-18) yıl olan 51 hasta (24 kız, 27 erkek) çalışmaya dahil edildi: sırasıyla nöroblastom, ewing sarkomu, hodgkin lenfoması, hodgkin dışı lenfoma, germ hücreli tümör ve yumuşak doku sarkomu olan 20, 15, 8, 4, 2 ve 2 hasta vardı. Hastaların nötrofil ve trombosit engraftman ortanca süreleri sırasıyla 11 (8-45) gün ve 16 (4-62) gün ve ortanca hastanede kalış süresi 38 (17-67) gün idi. Tüm hastalarda ortanca takip süresi 2.83 (0.12-10.81) yıl ve genel sağkalım %51.3±10.3; Ewing sarkomu ve nöroblastom olgularının ortanca takip süreleri ve sağkalım oranları sırasıyla 2,63 (0,12-10,55) yıl ve % 64,2 ±14,9 ve 2,81 (0,31-7,91) yıl ve %42,8±12 idi. Nöroblastom hastalarında; karboplatin, etoposid, melfalan (CEM) hazırlık rejimi olarak alan 4 hastanın tümü ölürken, hazırlık rejimi olarak busulfan ve melfalan (Bu/Mel) rejimi alan 16 hastanın 6'sı öldü: Bu/Mel grubunun ortanca takip süresi 3.08 (0.32-7.91) yıl ve genel sağkalım %55,1±13,8 idi (p:0,001).
Sonuç: Hasta sayımızın sınırlı olmasına rağmen, kliniğimizde Ewing sarkomu ve nöroblastom olgularımızda elde edilen verilerde ve literatürde OHKHT'nin yapılmayan hastalara göre daha iyi sağkalım sağladığı görülmektedir.
SAĞLIK İŞLETMELERİNDE ETİK LİDERLİĞİN DİLE GETİRME DAVRANIŞLARI ARACILIĞIYLA İŞ PERFORMANSINA ETKİSİ: ÖRGÜTSEL AİDİYETİN DÜZENLEYİCİ ROLÜ
Authors: YILDIZ Ayşe Tuğba , DEMİRTAŞ Özgür
Published: September 2022

ÖZET

Bu çalışmanın amacı dile getirme davranışı aracı (mediating) rolde iken etik liderlik davranışlarının iş performansı üzerindeki etkisini incelemektir. İlave olarak günümüzde bireylerin iş performansının artırılmasında etkili bir algı olan örgütsel aidiyet değişkeni de düzenleyici rolde çalışmada yer almaktadır. Bu amaç doğrultusunda Kayseri’de bulunan sağlık kurumlarında tam zamanlı olarak çalışan 415 sağlık çalışanı üzerinde anket tekniği ile veriler yüz yüze toplanmıştır. Çalışma sonucunda etik liderliğin iş performansını pozitif yönde etkilediği, dile getirme davranışlarının ise bu ilişkide kısmi aracı role sahip olduğu tespit edilmiştir. İlave olarak da örgütsel aidiyetin etik liderlik ve dile getirme davranışları ilişkisinde düzenleyici rolde olmadığı bulunmuştur.
İŞ OTONOMİSİNİN PSİKOLOJİK İYİ OLUŞ ÜZERİNE ETKİSİ: PSİKOLOJİK DAYANIKLILIĞIN ARACI ROLÜ
Authors: KAPLAN Merve , ÖZTÜRK Mehtap
Published: September 2022

Psikolojik iyi oluş bireyin duygusal ve bilişsel iyi oluşunu inceleyen bir kavramdır. Son yıllarda, örgütlerde iyi oluşu konu alan araştırmacılar dikkate değer bir ilgi görmektedir. İyi oluşa yönelik yapılan araştırmalarda kaygı, psikolojik sıkıntı, zayıf fiziksel sağlık, düşük performans gibi faktörlerin bireyler ve örgütler üzerindeki zararlı etkileri vurgulanmaktadır (Ryff, 1995). Ancak psikolojik iyi oluşun sadece çalışanların optimal işleyişini anlamanın yanı sıra çalışanların sağlığını, mutluluğunu ve iyiliğini teşvik etmenin örgütlerde meşru hedeflere ulaşmanın bir yolu olması nedeniyle iyi oluş kavramına ilgi yoğunlaşmaktadır. Bu doğrultuda bu çalışmada çalışanların psikolojik dayanıklılık ve psikolojik iyi oluş düzeylerinin iş otonomisi üzerinde nasıl bir etkiye sahip olduğunu anlamaya yönelik bankacılık sektöründe 411 çalışan üzerinde bir araştırma yapılmıştır. Araştırma sonucunda iş otonomisi ve psikolojik dayanıklılığın psikolojik iyi oluş üzerinde pozitif yönlü, istatiksel olarak anlamlı etkiye sahip olduğu tespit edilmiştir. Ayrıca araştırmada psikolojik iyi oluş ve iş otonomisi arasındaki istatistiksel ilişkide psikolojik dayanıklılığın aracı rolü olduğu sonucuna ulaşılmıştır.
TVP-VAR Tabanlı CARR Oynaklık Bağlantılılığı: Rusya-Ukrayna Çatışmasından Kanıtlar
Authors: ARI Yakup
Published: September 2022

Bu çalışma Zamanla Değişen Parametreli Vektör Otoregresif (TVP-VAR) tabanlı Diebold-Yılmaz yaklaşımı ile Koşullu Otoregresif Aralık (CARR) sürecinden elde edilen oynaklıklar arasındaki yayılmayı incelemeyi amaçlamaktadır. Çalışmada volatiliteleri tahmin etmek için Gumbel olasılık dağılımına sahip CARR (1,1) uygulanmıştır. Özet istatistikler serilerin normal dağılım göstermediğini ve inovasyonların Gumbel dağılımına uyduğunu göstermektedir. Ayrıca elde edilen oynaklık serileri durağandır. Bunların yanında tüm serilerde ve kare serilerde anlamlı bir otokorelasyonun ortaya çıktığı gözlemlenmiştir. Bu nedenle, zamanla değişen varyans-kovaryans yapısına sahip bir TVP-VAR modeli tüm bu ampirik özellikleri yakalamak için uygun bir ekonometrik çerçevedir. Metodolojik yaklaşıma örnek olarak Ukrayna-Rusya Savaşının küresel piyasalar üzerindeki etkisini ortaya koyan bir uygulama sunulmuştur. Bu amaçla, bağlantılılık analizini gerçekleştirmek için varlık büyüklüğüne göre küresel ölçekte en büyük yirmi borsa arasından seçilen endeksler ile Rus borsa endeksi verisini içeren TVP-VAR analizi iki gruba ayrılmıştır. İlk grubu oluşturan panelde Rus borsa endeksinin oynaklığı dahil edilmezken, ikinci panele dahil edilerek ortalama toplam bağlantılılık endeksleri hesaplanmıştır. Bulgular, toplam bağlantılılık endeksinin ilk panelde %79,91 olduğunu ve Rusya pazarının eklenmesiyle %81,44'e yükseldiğini göstermektedir.
Einfluss der Frässpindel-Orientierung auf die Bearbeitungsgenauigkeit beim Fräsen mit Industrierobotern
Authors:   Ruhr-Universität Bochum, Josler Lars Niklas , Möllensiep Dennis ,   Ruhr-Universität Bochum, Kuhlenkötter Bernd ,   Ruhr-Universität Bochum
Published: September 2022

Industrieroboter finden zunehmend Anwendung bei Bearbeitungsprozessen. Hier weisen die Roboter bedingt durch ihre vergleichsweise geringe Steifigkeit eine deutlich höhere Abdrängung des Endeffektors, als herkömmliche CNC-Maschinen, auf. Dieser Beitrag stellt einen Ansatz zur Minimierung solcher Abdrängungen des Werkzeugs durch die Ausnutzung der rotatorischen Freiheitsgrade an der Frässpindel vor. Hierzu wurde die Abdrängung des Endeffektors bei unterschiedlichsten Orientierungen der Frässpindel mittels eines Strukturmodells untersucht.
Cystatin C Levels, Status of Oxidant-Antioxidant and Inflammation in Hemodialysis Patients
Authors: MERT Handan , DURGAÇ Murat , ÖZCAN Neyran , MİS Leyla , MERT Nihat
Published: September 2022

Objective: Cystatin C is considered an important marker for the detection of renal dysfunction. It was aimed to determine cystatin C levels, status of oxidant-antioxidant and inflammation in hemodialysis (HD) patients.
Methods: The study groups consisted of 20 HD patients and 20 healthy controls. Blood samples were obtained from the control group and from the HD group before hemodialysis. Serum cystatin C, total antioxidant capacity (TAC), total oxidative state (TOS), tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6) interleukin 18 (IL-18) levels were detected by Enzyme Linked Immunosorbent Assay (ELISA), C-reactive protein (CRP) and some biochemical parameters were analyzed by autoanalyser.
Results: Cystatin C, TOS, TNF-α, IL-6, IL-18 and CRP levels of the HD group were significantly higher than the control group.
Conclusion: As a result; oxidative stress and inflammation were increased in patients with chronic renal failure undergoing hemodialysis. New strategies and new studies are needed to reduce the increase in oxidative stress and inflammation in HD patients.
Evaluation of Dry Eye Parameters in Patients with Unilateral Herpetic Keratitis
Authors: SUBASİ Sevgi
Published: September 2022

Objective: Our aim in this study was to examine the tear parameters between affected and unaffected eyes of unilateral herpes simplex virus (HSV) keratitis patients, especially the meibomian glands status.
Methods: The examinations and tear parameters including; tear film meniscus height (TMH) and area (TMA), non-invazive break up time (NIBUT), schirmer test, meibomian gland’s ekspressibility grade, drop out grade and microstructure of patients who were treated in our clinic with the diagnosis of unilateral herpetic endothelitis or herpetic stromal keratitis, and who had a quiescent period of about 3 months, were evaluated retrospectively.
Results: The median age of our patients was 58.0 (55.25-72.25) years. The median NIBUT was 6.85 (4.62-17.0) sec. in affected eye and 15.85 (10.47-17.15) sec. in unaffected eye. NIBUT values were observed to be remarkable lower in the affected eye, although the change between groups was not statistically significant. Schirmer test values, TMH and TMA were similar between affected and unaffected eyes. Meibomian gland evaluations of affected and unaffected eyes were shown similar distribution across meibomian expressibility and drop out grades.
Conclusion: We observed similar effects in both morphological and microstructural features of meibomian glands in both eyes. This condition makes us think that the developing dry eye disease in both eyes may be caused not only by neurosensorial anomalies but also by changes in the meibomian glands.
Transnational Class Actions: The Canadian Experience and the Improvement of Access to Justice in Latin America
Authors: da Silva Larissa Clare Pochmann
Published: September 2022

This paper analyses how the Canadian experience of class actions could contribute to the improvement of access to justice in Latin American, in a scene that damages are no longer restricted to state borders. For that, the text clarifies the concept of transnational class actions and how they could improve the prevention and reparation of damages that are no longer restricted to state borders. Then, based on the Canadian experience, that are different models of class actions, proposals are made for the admissibility and enforcement of transnational class actions in Latin American context. Keywords: Transnational class actions; Latin America; Canada.
Genealogy, Variations and Specificity of the Right to Truth
Authors: Latino Agostina
Published: September 2022

This essay focuses on the right to truth as a specific guarantee of the human person, characterised by both an individual and collective dimension, especially in the context of transitional justice. The analysis takes as its perimeter of investigation both the normative datum, which highlights its development in three phases (at first exclusively in the sphere of international humanitarian law, then circumscribed to the context of enforced disappearances, and today applicable in any case of serious violation), and the practice of the decisions of international tribunals and human rights control mechanisms. The aim is to highlight how the right to truth, far from constituting an aspiration that is more ethical than juridical or a mere explication of pre-existing rights already established, can, if crystallised, serve the pursuit of its own objectives that would be difficult to achieve without it. Keywords: Human rights; Rights to the truth; Transitional justice; Gross violations
The Rohingya Crisis: A Critical Analysis of the United Nations Security Council and International Human Rights Law
Authors: Nartey Emmanuel K
Published: September 2022

This essay reviews the human rights violations against the Rohingya people in 2017 and assesses the effectiveness of accountability under the United Nations Security Council (UNSC). It is concluded that under the principles of ethics and integrity in international law and human rights law, there should have been investigations into the crimes committed against Rohingya Muslims in accordance with the judgement given by the ICC's Pre-Trial Chamber. The essay underlines the fundamental principles of ethics and integrity in international law and human rights law. The principles of ethics and integrity in international law should have allowed the UNSC to act in accordance with the international doctrine of human rights. It is concluded that the UNSC's failure to carry out its obligations was solely due to Russia's political ties with Myanmar, which also resulted in Russia using its veto power and obstructing the UNSC's statement on the situation. The banal approach to the implementation and enforcement of international law and human rights has paralysed the principle of ethics and integrity. In this light, the essay affirms there is a need to create a better framework to resolve issues such as the Rohingya genocide and the Russian invasion of Ukraine and any complications that may arise in the future. It is suggested that in addition to the United Nations Assembly and the UNSC, there is a need to create a conflict management body within these two settings. Keywords: Accountability; Genocide; Human Dignity; Human Rights Law; Human Rights Violations; International law; Rohingyal; Russia; States; Ukraine; United National General Assembly; United National Security Council;
Why the World Needs Futures Studies: A Social and Methodological Challeng
Authors: Facioni Carolina
Published: September 2022

This work aims to focus on the absolute need that the world has today of Futures Studies. Thanks to this discipline’s historical and methodological specificities in human sciences’ context, Futures Studies can help humankind to manage the critical issues that are threatening it. The topic will be discussed through an exclusively theoretical approach, also describing the Italian contribution to Futures Studies: e.g., Eleonora Barbieri Masini’s work, or Aurelio Peccei’s, who (as early as the 1960s) was among the first to emphasize (in a complex approach) the risks the Earth would run. Nowadays, the delay in the actions that could have been taken many years ago places the world in front of previously unthinkable scenarios. New migrations caused by climate changes, possible criticalities due to the lack of demographic balance in the world population, our own survival as a living species at risk. In this sense, the new challenges that Futures Studies have to face are both socio-cultural and (in a particular approach) methodological. In the present times, many situations at the international level seem to have reached their limits. There is very little time to eventually refine (or change) the tools both of analysis and problem solving. As Aurelio Peccei pointed out in his time, phenomena (and problems) interact with each other in a very complex way. So, Futures Studies can help in the search for a possible solution by giving their particular multidisciplinary and overall look. Keywords: Futures Studies, Italian contribution, world criticalities, methodological issues
Knowledge, Attitude, and Practices (KAP) Towards COVID-19 among Older People Living in Informal Settlements in Nairobi City, Kenya
Authors: Okoth Okaka Fredrick , Omondi Paul
Published: September 2022

Informal settlements in developing countries such as Kenya are the least prepared to deal with COVID-19 pandemic due to lack of basic housing, water and sanitation, and overcrowding. The risk is magnified for older people in such an environment due to their advanced age that compromises their immune system, and the fact that they are more likely to have pre-existing health conditions which weaken their body’s ability to fight infectious diseases. This study sought to establish older people’s knowledge levels, perception, and risk assessment with regard to COVID-19, and adherence to prevention measures. A cross-sectional survey was conducted among 150 respondents aged 60 years and above from two selected informal settlements in the city of Nairobi during the month of August 2020. Primary data were collected using questionnaire and analyzed using descriptive statistics that involved the use of frequencies, totals and percentages. Knowledge of dry cough and fever as COVID-19 symptoms was high, but only 31.5% listed difficulty in breathing. Slightly over half correctly identified elderly people as being at greatest risk of getting severely sick from COVID-19. About 60% were aware that they are at risk of contracting COVID-19. Strong religious belief was the main reason among those who believed they are not at risk. Wearing face masks and hand-washing using soap were the main prevention measures adopted. In conclusion, the study revealed that knowledge about some key symptoms of COVID-19 is still low, and that a considerable number of older people do not think that elderly people are at great risk of getting severely sick. Misconception that a strong religious belief can protect one from contracting the disease is still common among older people. There is, therefore, need for well-tailored and contextualized awareness campaigns to reach this high risk group. Keywords: COVID-19, older people, slums, knowledge, behavior
“As Long as the Boat Goes”: Singing by Metaphor in the Years of Lead
Authors: Bellini Pier Paolo
Published: September 2022

“There is everything in the Sixties ... it is a phase of magmatic confrontation” (Colombo 1998, p. 248). Those that in Italy will be called “years of lead”, marked by the well known dramatic social and cultural changes, claim the tension of real “worlds” and “point of view of worlds” alternative, a new and an old no longer reconcilable, but forced to cohabitate. The Italian song of those years is a photograph of this situation: in it, old aspirations, imaginary, values face each other with new ones, without getting to definitively eliminate the antagonists. If it is true that the text of the most famous “ditty” of the Italian singer Orietta Berti is able to make people talk about its hidden meaning even today, it must be admitted that the musical creation of those years is a forge of “polysemic” production. “Where there is metaphor, there is conflict” (Goodman 1968, p. 67). Even in its narrative function, the metaphor presents conflict: it can have, in fact, a “selective” function or, on the contrary, an “explanatory” function, aimed at favoring the understanding of obscure things, those not easily communicable through the usual narrative practices. Keywords: metaphor, Masscult, sense and meaning, multichannel, polysemy