bluuebunny/crossref_metadata_2025 huggingface dataset:
Telephone-Cardiopulmonary Resuscitation Guided by a Telecommunicator: Design of a Guiding Algorithm for Telecommunicators
Authors: Yacobis-Cervantes Tamara Rafaela , García-Méndez Juan Antonio , Leal-Costa César , Castaño-Molina María Ángeles , Suárez-Cortés María , Díaz-Agea José Luis
Published: September 2023

Background: Out-of-hospital cardiac arrest is considered a global problem. In the last few years, there has been a growing interest in telephone-cardiopulmonary resuscitation guided by a telecommunicator. Indeed, several studies have demonstrated that it increases the chances of survival rate. This study focuses on the key points the operator should follow when performing telephone-cardiopulmonary resuscitation. The main objective of this paper is to design an algorithm to improve the telephone-cardiopulmonary resuscitation response protocol. Methods: The available evidence and the areas of uncertainty that have not been previously mentioned in the literature are discussed. All the information has been analyzed by two discussion groups. Later, a consensus was reached among all members. Finally, a response algorithm was designed and implemented in clinical simulation. Results: All the witnesses were able to recognize the OHCA, call for emergency assistance, follow all the operator’s instructions, move the victim, and place their hands in the correct position to perform CPR. Discussion: The results of the pilot study provide us a basis for further experimental studies using randomization and experimental and control groups. Conclusions: No standardized recommendations exist for the operator to perform telephone-guided CPR. For this reason, a response algorithm was designed.
Effects of Mobilization within 72 h of ICU Admission in Critically Ill Patients: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Matsuoka Ayaka , Yoshihiro Shodai , Shida Haruka , Aikawa Gen , Fujinami Yoshihisa , Kawamura Yusuke , Nakanishi Nobuto , Shimizu Motohiro , Watanabe Shinichi , Sugimoto Kensuke , Taito Shunsuke , Inoue Shigeaki
Published: September 2023

Previous systematic review and meta-analysis indicates that rehabilitation within a week of intensive care unit (ICU) admission benefits physical function in critically ill patients. This updated systematic review and meta-analysis aim to clarify effects of initiating rehabilitation within 72 h of ICU admission on long-term physical, cognitive, and mental health. We systematically searched the MEDLINE, Cochrane Central Register of Controlled Trials, and Igaku Chuo Zasshi for randomized controlled trials (RCTs) between April 2019 and November 2022 to add to the previous review. Two investigators independently selected and extracted data. Pooled effect estimates for muscle strength, cognitive function, mental health after discharge, and adverse events were calculated. Evidence certainty was assessed via Grading of Recommendations, Assessment, Development, and Evaluations. Eleven RCTs were included in the meta-analysis. Early rehabilitation may improve muscle strength (three trials; standard mean difference [SMD], 0.16; 95% confidence interval [CI], −0.04–0.36) and cognitive function (two trials; SMD, 0.54; 95% CI, −0.13–1.20). Contrastingly, early mobilization showed limited impact on mental health or adverse events. In summary, initiating rehabilitation for critically ill patients within 72 h may improve physical and cognitive function to prevent post-intensive care syndrome without increasing adverse events. The effect on mental function remains uncertain.
Risk Factors and Predictors for Functional Outcome and Complication Rate in Total Hip Arthroplasty through Minimally Invasive and Conventional Approaches: A Systematic Review and Meta-Regression Analysis of 41 Randomized Controlled Trials
Authors: Ramadanov Nikolai , Ostojic Marko , Lazaru Philip , Liu Kuiliang , Hable Robert , Marinova-Kichikova Polina , Dimitrov Dobromir , Becker Roland
Published: September 2023

Objective: To investigate and identify risk factors and predictors for the difference in functional outcome and complications between total hip arthroplasty (THA) through minimally invasive and conventional approaches, using a meta-regression analysis of randomized controlled trials (RCTs). Methods: A systematic review of the literature up to 31 July 2022 was performed. A meta-regression was conducted based on a random effects meta-analysis using the Hartung–Knapp–Sidik–Jonkman method. Results: A total of 41 RCTs with 3607 patients were found. The following predictors of HHS ≥ 6 months postoperatively were identified: patient age (predictor estimate = 0.14; p < 0.01), avascular necrosis of the femoral head (predictor estimate = −0.03; p = 0.04); incision length (predictor estimate = −0.82; p < 0.01). The following predictors of complication rate were identified: osteoarthritis (predictor estimate = 0.02; p = 0.02); femoral neck fracture (predictor estimate = −0.02; p = 0.02); SuperPATH (predictor estimate = −1.72; p < 0.01). Conclusions: Patient age, avascular necrosis of the femoral head, and incision length were identified as predictors of the effect size of the HHS ≥ 6 months postoperatively; and osteoarthritis, femoral neck fracture, and SuperPATH as predictors of the effect size of the complication rate. Based on these findings, we recommend that more frequent use of minimally invasive THA in elderly patients should be considered. Level of evidence I: a systematic review of all relevant randomized controlled trials. Registered in PROSPERO on 10 August 2022 (CRD42022350287).
Study of the Law Motion of the Micro-EDM Drilling Process
Authors: Pellegrini Giuseppe , Ravasio Chiara
Published: September 2023

Micro-EDM is an unconventional technology used to machine every type of electrically conductive material regardless of its mechanical properties. Material removal occurs through electrical discharges between the workpiece and the electrode immersed in a dielectric fluid. In drilling operations, the technology is able to realise microholes with excellent quality in terms of precision, quality surface, roundness, and taper to the detriment of the machining time, which is less than other technologies. Several efforts are being made to improve different features related to the process performance that are severely affected by both the operative conditions, such as the electrode material or the type of dielectric, and process parameters. The typical indexes used to characterise the performance are the machining time, the material removal rate, and the geometric indexes. These indexes are very effective and are easily measurable, but they do not give information about the evolution of the drilling process, which could be irregular due to the different phenomena occurring during machining. The aim of this paper is the development of a method able to elaborate the motion law of the electrode during the micro-EDM drilling operation. In order to do this, a single hole was manufactured in several steps, recording both the machining time and electrode wear for each step. In this way, the actual position of the electrode during the drilling can be measured without the use of a predictive model for electrode wear. It was tested to confirm that the multistep procedure did not introduce new phenomena, in contrast to the traditional drilling operation. This method was used to study the effects of the electrode diameter, the type of electrode, the length of the electrode out of the spindle, and the entity of the run-out on the process performance. The tests were executed on titanium alloy sheets using a tungsten carbide electrode and hydrocarbon oil as the dielectric. It was found that the descent of the electrode into the workpiece was not regular, but it depended on the level of debris concentration in the machining zone. The debris concentration was influenced by the type and diameter of the electrode, its length out of the spindle, and, to a lesser extent, the run-out. This method was found to be a useful method for an in-depth analysis of the micro-EDM drilling process, contributing to a better understanding of the physical aspects of the process.
The Effect of Heating on Properties of Sandy Soils
Authors: Šurda Peter , Lichner Ľubomír , Iovino Massimo , Hološ Slavomír , Zvala Anton
Published: September 2023

Although burning grass and crop residues is prohibited in many countries, farmers perceive it as a quick and inexpensive way to eliminate unwanted biomass. The aim of this study was to estimate the impact of heating temperature (simulation of biomass burning) on the studied properties (soil organic carbon (SOC) content, pH(H2O), water drop penetration time, WDPT, and contact angle, CA) of acidic sandy soils. Soil samples were taken from the experimental sites S1, S2, and S3 at Studienka village in the Borská nížina lowland (southwestern Slovakia). Experimental site S1 was arable land, experimental site S2 was arable land abandoned for approximately 10 years, and experimental site S3 was arable land abandoned for approximately 30 years with scattered Scots pine (Pinus sylvestris L.) trees. It was found that all the soil properties studied were strongly affected by heating. A drop in SOC was observed in all the soils for the heating temperature between 20 and 600 °C. Due to the incomplete combustion of SOC, a small (0.1–0.7%) SOC content was recorded even in soils heated to between 600 and 900 °C. An increase in pH(H2O) was observed in all the soils for the heating temperature higher than 300 °C. Soil from the experimental site S1 was wettable (WDPT < 5 s) for all of the heating temperatures. WDPT vs. heating temperature relationships for the soils from the experimental sites S2 and S3 were more complex. After a decrease in the heating temperature of 50 °C, an increase in WDPT for the heating temperature between 50 °C and 300 °C (for S3 soil) and 350 °C (for S2 soil) was registered. Finally, the WDPT dramatically dropped to 0 for the heating temperature of 350 °C (for S3 soil) and 400 °C (for S2 soil). CA started to decrease at 300 °C in all the soils and dropped to 0° for all the soils at 800 °C. CA > 0° measured in soils for the heating temperature between 400 and 800 °C, as a consequence of the small SOC contents due to the incomplete combustion of SOC, is a novelty of this study which demonstrates that CA is more sensitive to the changes in subcritical water repellency than WDPT.
Assessment of Sustainable Development Suitability in Linear Cultural Heritage—A Case of Beijing Great Wall Cultural Belt
Authors: He Ding , Hu Jingchong , Zhang Jie
Published: September 2023

The Great Wall is an example of linear cultural Heritage (LCH) subjected to a fragile ecological environment and unbalanced economic development. However, no studies have been conducted to assess the sustainable development suitability (SDS) of the Great Wall region. Heritage area development assessments can increase public and government knowledge of the state of heritage areas and aid decision makers in formulating sensible policies or plans to protect and develop heritage areas. The valley is the spatial model of mountain economic development proposed on the basis of a basin combined with the ecological protection, rural development, and cultural inheritance present in mountainous areas. This study chose 169 valley units in the Beijing Great Wall Cultural Belt as research objects. A 15-indicator assessment index system was established based on the ecological, socio-economic, and cultural dimensions. The assessment procedure was enhanced by employing the triangle graphical method, and spatial autocorrelation was used to study the geographical distribution features of the development suitability scores derived from the research region. The results show the following facts: (1) Yanqing, Huairou, Miyun, Pinggu, and Changping have high development suitability results, whereas Mentougou and Changping have low scores. (2) In total, 96 valley units have practical advantages, and 51.5% are comprehensive development types (with advantages in at least two aspects). (3) Valley development suitability scores spatially cluster into seven high- and low-value groups. The ecological carrying capacity of the Badaling Cluster cannot maintain its overheated development. The results match up well with the objective condition of planning in the Beijing Great Wall National Cultural Park. We conclude that the proposed indicator framework and analytical method can be transferred to cases with similar contexts.
Africa (COVID-19) Vaccine Technology Transfer: Where Are We?
Authors: Oladipo Elijah Kolawole , Olufemi Seun Elijah , Ojo Taiwo Ooreoluwa , Adediran Daniel Adewole , Idowu Akindele Felix , Idowu Usman Abiodun , Onyeaka Helen
Published: September 2023

The rampant spread of the COVID-19 infection poses a grave and formidable challenge to global healthcare, with particular concern to the inhabitants of the African continent. In response to these pressing concerns, different strategies have been employed to combat the emergence of this insidious disease, encompassing crucial measures such as physical distancing, the utilization of face masks, meticulous hand hygiene, and widespread vaccination campaigns. Nevertheless, the economic realities faced by numerous African nations, characterized by their classification as “low-income countries (LICs)”, present a formidable barrier to accessing and distributing approved vaccines to their populations. Moreover, it is essential to discuss the hesitancy of the European Union (EU) in releasing intellectual property rights associated with the transfer of vaccine technology to Africa. While the EU has been a key player in global efforts to combat the pandemic, there has been reluctance in sharing valuable knowledge and resources with African countries. This hesitancy raises concerns about equitable vaccine access and the potential for a prolonged health crisis in Africa. This review underscores the urgent imperative and need of establishing localized vaccine development and production facilities within Africa, necessitating the active involvement of governments and collaborative partnerships to achieve this crucial objective. Furthermore, this review advocates for the exploration of viable avenues for the transfer of vaccine technology as a means to facilitate equitable vaccine access across the African continent and also the cruciality and the need for the EU to reconsider its stance and actively engage in transferring vaccine technology to Africa through sharing intellectual property. The EU can contribute to the establishment of localized vaccine production facilities on the continent, which will not only increase vaccine availability but also promote self-sufficiency and resilience in the face of future health emergencies.
Optimization of High-Efficiency Tissue Culture Regeneration Systems in Gray Poplar
Authors: Li Huanhuan , Wang Hang , Guan Lianke , Li Zihui , Wang Hua , Luo Jie
Published: September 2023

A series of tissue culture regeneration protocols were conducted on gray poplar (P. tremula × P. alba) to select the most efficient callus induction medium, adventitious shoot differentiation medium, shoot elongation medium and rooting medium, which laid the foundation for the optimization of genetic transformation technology for gray poplar. The results showed that the Woody Plant Medium (WPM) supplemented with 0.10 mg L−1 kinetin (KT) and 1.00 mg L−1 2,4-dichlorophenoxyacetic acid (2,4-D) was the most suitable medium for callus induction. The callus induction rates of different tissues were greater than 85.7%. The optimal adventitious shoot differentiation medium was the WPM supplemented with 0.02 mg L−1 thidiazuron (TDZ), and the adventitious shoot differentiation rates of young tissues were 22.2–41.9%. The optimal direct differentiation medium was the Murashige and Skoog (MS) medium supplemented with 0.20 mg L−1 6-benzylaminopurine (6-BA), 0.10 mg L−1 indole butyric acid (IBA) and 0.001 mg L−1 TDZ, and the differentiation rate of adventitious shoots was greater than 94%. The best shoot elongation medium for adventitious shoots was the MS medium with 0.10 mg L−1 naphthylacetic acid (NAA). After 45 days of cultivation in the MS medium with 0.10 mg L−1 NAA, the average plant height was 1.8 cm, and the average number of elongated adventitious shoots was 11 per explant. The 1/2 MS medium with 0.10 mg L−1 NAA showed the best performance for rooting, and later, shoot growth. The direct shoot induction pathway can induce adventitious shoots much faster than the indirect adventitious shoot induction pathway can, and the time cost via the direct adventitious shoot induction pathway can be shortened by 2–6 weeks compared to that of the indirect shoot induction pathway.
Prediction of Self-Loosening Mechanism and Behavior of Bolted Joints on Automotive Chassis Using Artificial Intelligence
Authors: Güler Birtan , Şengör Özgür , Yavuz Onur , Öztürk Ferruh
Published: September 2023

The tightening torque values considered in the assembly of vehicle subparts are of great importance in terms of connection safety. The torque value to be selected is different for each bolted joint type with respect to mechanical features. While the tightening torque value is an important indicator, the bolt preloading value is always a more reliable parameter in terms of whether a secure tightening can be achieved or not. For this reason, when it is desired to create reliable joints, the preloading value that the tightening torque input will create on the connection package should be calculated well. This study presents an integrated approach using Taguchi method (TM) and neural network (NN) to predict the self-loosening mechanism of bolted joints in automotive chassis engine suspension connections. External loading acting on the joints of the engine suspension was collected from bench tests. NN was applied to establish the relationship between controlled factors and loosening rate. The results showed that the proposed approach can be used to predict mechanism of self-loosening and behavior of bolted joints without additional tests, and it is possible to make predictions with very low error rates using artificial intelligence techniques.
Structure and Metabolically Oriented Efficacy of Fucoidan from Brown Alga Sargassum muticum in the Model of Colony Formation of Melanoma and Breast Cancer Cells
Authors: Usoltseva Roza V. , Zueva Anastasiya O. , Malyarenko Olesya S. , Anastyuk Stanislav D. , Moiseenko Olga P. , Isakov Vladimir V. , Kusaykin Mikhail I. , Jia Airong , Ermakova Svetlana P.
Published: September 2023

This work reports the detailed structure of fucoidan from Sargassum miticum (2SmF2) and its ability to potentiate the inhibitory effect of glycolysis inhibitor 2-deoxy-d-glucose (2-DG). 2SmF2 was shown to be sulfated and acetylated galactofucan containing a main chain of alternating residues of 1,3- and 1,4-linked α-l-fucopyranose, fucose fragments with monotonous 1,3- and 1,4-type linkages (DP up to 3), α-d-Gal-(1→3)-α-L-Fuc disaccharides, and 1,3,4- and 1,2,4-linked fucose branching points. The sulfate groups were found at positions 2 and 4 of fucose and galactose residues. 2SmF2 (up to 800 µg/mL) and 2-DG (up to 8 mM) were not cytotoxic against MDA-MB-231 and SK-MEL-28 as determined by MTS assay. In the soft agar-based model of cancer cell colony formation, fucoidan exhibited weak inhibitory activity at the concentration of 400 µg/mL. However, in combination with low non-cytotoxic concentrations of 2-DG (0.5 or 2 mM), 2SmF2 could effectively inhibit the colony formation of SK-MEL-28 and MDA-MB-231 cells and decreased the number of colonies by more than 50% compared to control at the concentration of 200 µg/mL. Our findings reveal the metabolically oriented effect of fucoidan in combination with a glycolysis inhibitor that may be beneficial for a therapy for aggressive cancers.
Impact of Intraoperative Factors on the Development of Postpartum Septic Complications
Authors: Andzane Diana , Miskova Anna , Krone Antra , Rezeberga Dace
Published: September 2023

Background and Objectives: Triclosan-coated sutures (antibacterial sutures) can reduce the risk of postoperative surgical site infection. This study aimed to investigate the effect of intraoperative factors, including antibacterial sutures, on the risk of postpartum septic complications. Materials and Methods: The prospective study included patients who underwent caesarean section. The exclusion criterion was chorioamnionitis. The investigation group patient’s (n = 67) uterus and fascial sheath of the abdominal wall were sutured with triclosan-coated polyglactin 910 sutures during surgery. The control group consisted of 98 patients using uncoated polyglactin 910 sutures only. The patients were contacted by phone after the 30th postoperative day. Results: No significant difference was found between the investigation group and the control group in the development of postpartum endometritis (11.7% in the investigation group vs. 8.4% in the control group, p = 0.401), wound infection (6.3% vs. 3.6%, p = 0.444) or patients experienced any septic complication (15.9% vs. 12%, p = 0.506). Postpartum endometritis was more common in patients who underwent instrumental uterine examination during the surgery (23.8% vs. 18%, p = 0.043). A moderately strong correlation was found for haemoglobin level on the third–fourth postoperative day with the development of postpartum septic complications, p < 0.001, Pearson coefficient −0.319. Post-caesarean delivery septic complications were not statistically more common in patients with blood loss greater than 1 L. The incidence of post-caesarean endometritis was 13.4%, and wound infection was 4.8% in this study’s hospital, having five to six thousand deliveries per year. Conclusions: Using antibacterial sutures during caesarean section does not affect the incidence of postpartum septic complications. Instrumental uterine examination during caesarean section increases the risk of post-caesarean endometritis and is, therefore, not recommended. Haemoglobin level on the 3rd–4th postoperative day, rather than the estimated blood loss during surgery, affects the development of postpartum septic complications.
The Use of Superb Microvascular Imaging in Evaluating Rheumatic Diseases: A Systematic Review
Authors: Seskute Goda , Jasionyte Gabija , Rugiene Rita , Butrimiene Irena
Published: September 2023

Background and Objectives: Superb microvascular imaging is an advanced Doppler algorithm that seems to be useful in detecting low-velocity blood flow without using a contrast agent. Increasing evidence suggests that SMI is a more sensitive tool than conventional Doppler techniques for evaluating rheumatic diseases, especially inflammatory arthritis. We aimed to assess the use of SMI in evaluating joints and extraarticular structures. Materials and Methods: Two reviewers independently reviewed the literature to provide a global overview of the possibilities of SMI in rheumatology. Original English-language articles published between February 2014 and November 2022 were identified through database (PubMed, Medline, Ebsco, the Cochrane Library, and ScienceDirect) searching, and analysed to summarise existing evidence according to PRISMA methodology. Inclusion criteria covered original research articles reporting applications of SMI on rheumatic diseases and musculoskeletal disorders secondary to rheumatic conditions. Qualitative data synthesis was performed. Results: A total of 18 articles were included. No systematic reviews fulfilled our inclusion criteria. Most studies focused on characterising the synovial vascularity of rheumatoid arthritis. There have been several attempts to demonstrate SMI’s value for evaluating extra-articular soft tissues (fat pads or salivary glands) and large-diameter vessels. The quantitative importance of SMI vascular indices could become a useful non-invasive diagnostic marker. Studies on therapeutic applications are still scarce, and the majority of studies have gaps in reporting the methodology (ultrasound performance technique and settings) of the research. Conclusions: SMI has proved to be useful in characterising low-flow vascularity, and growing evidence indicates that SMI is a non-invasive and lower-cost tool for prognostic assessment, especially in inflammatory arthritis. Preliminary findings also suggest potential interest in evaluating the effect of treatment.
Effect of Birch Sap as Solvent and Source of Bioactive Compounds in Casein and Gelatine Films
Authors: Carpintero María , Marcet Ismael , Zornoza María , Rendueles Manuel , Díaz Mario
Published: September 2023

Birch sap consists of a natural water-based solution with valuable compounds such as minerals, sugars, organic acids and phenolic compounds that can be used advantageously in the preparation of edible films. In this study, gelatine- and casein-based films were prepared using birch sap as biopolymer solvent and source of bioactive compounds with the aim of developing new bioactive materials for food packaging. The physical, mechanical, barrier, antioxidant and iron-chelating properties of the obtained films were investigated. Birch sap enhanced the mechanical properties of the films by increasing puncture strength and flexibility, as well as their ultraviolet–visible light barrier properties. In addition, the presence of bioactive compounds endowed the birch sap films with an antioxidant capacity of almost 90% and an iron-chelating capacity of 40–50% with respect to the control films. Finally, to test these films as food packaging material, a photosensitive curcumin solution was packed and exposed to ultraviolet light. Tested films were able to protect curcumin against photodegradation, and the presence of bioactive compounds inside the birch-sap-enriched materials offered an additional 10% photoprotective effect compared to control films. Results showed the potential of birch sap as an environmentally friendly biopolymer solvent and plasticizer that can improve the mechanical and photoprotective properties of the prepared materials.
Carbon Nano-Onions as Nanofillers for Enhancing the Damping Capacity of Titanium and Fiber-Reinforced Titanium: A Numerical Investigation
Authors: Giannopoulos Georgios I. , Batsoulas Nikolaos D.
Published: September 2023

Improving the damping capacity of metal matrix composites is crucial, especially for applications in the aerospace industry where reliable performance against vibrations and shocks is mandatory. The main objective of the present study is the numerical prediction of the damping behavior of alpha titanium matrix nanocomposites reinforced with hollow carbon nano-onions at various volume fractions. According to the proposed numerical scheme, a structural transient analysis is implemented using the implicit finite element method (FEM). The metal matrix nanocomposites are modeled via the utilization of appropriate representative volume elements. To estimate the mechanical and damping behavior of the nanocomposite representative volume elements, axial sinusoidally time-varying loads are applied to them. The damping capacity of the metal matrix nanocomposites is then estimated by the arisen loss factor, or equivalently the tan delta, which is computed by the time delay between the input stress and output strain. The analysis shows that the loss factor of alpha titanium may be improved up to 60% at 100 Hz by adding 5 wt% carbon nano-onions. The numerical outcome regarding the dynamic properties of the carbon nano-onions/alpha titanium nanocomposites is used in a second-level analysis to numerically predict their damping performance when they are additionally reinforced with unidirectional carbon fibers, using corresponding representative volume elements and time-varying loadings along the effective direction. Good agreement between the proposed computational and other experimental predictions are observed regarding the stiffness behavior of the investigated metal matrix nanocomposites with respect to the mass fraction of the carbon-onion nanofillers in the titanium matrix.
The Metabolic Footprint of Systemic Effects in the Blood Caused by Radiotherapy and Inflammatory Conditions: A Systematic Review
Authors: Jelonek Karol , Mrowiec Katarzyna , Gabryś Dorota , Widłak Piotr
Published: September 2023

Response to radiotherapy (RT) includes tissue toxicity, which may involve inflammatory reactions. We aimed to compare changes in metabolic patterns induced at the systemic level by radiation and inflammation itself. Patients treated with RT due to head and neck cancer and patients with inflammation-related diseases located in the corresponding anatomical regions were selected. PubMed and Web of Science databases were searched from 1 January 2000 to 10 August 2023. Twenty-five relevant studies where serum/plasma metabolic profiles were analyzed using different metabolomics approaches were identified. The studies showed different metabolic patterns of acute and chronic inflammatory diseases, yet changes in metabolites linked to the urea cycle and metabolism of arginine and proline were common features of both conditions. Although the reviewed reports showed only a few specific metabolites common for early RT response and inflammatory diseases, partly due to differences in metabolomics approaches, several common metabolic pathways linked to metabolites affected by radiation and inflammation were revealed. They included pathways involved in energy metabolism (e.g., metabolism of ketone bodies, mitochondrial electron transport chain, Warburg effect, citric acid cycle, urea cycle) and metabolism of certain amino acids (Arg, Pro, Gly, Ser, Met, Ala, Glu) and lipids (glycerolipids, branched-chain fatty acids). However, metabolites common for RT and inflammation-related diseases could show opposite patterns of changes. This could be exemplified by the lysophosphatidylcholine to phosphatidylcholine ratio (LPC/PC) that increased during chronic inflammation and decreased during the early phase of response to RT. One should be aware of dynamic metabolic changes during different phases of response to radiation, which involve increased levels of LPC in later phases. Hence, metabolomics studies that would address molecular features of both types of biological responses using comparable analytical and clinical approaches are needed to unravel the complexities of these phenomena, ultimately contributing to a deeper understanding of their impact on biological systems.
Tackling Drug-Resistant Tuberculosis: New Challenges from the Old Pathogen Mycobacterium tuberculosis
Authors: Mancuso Giuseppe , Midiri Angelina , De Gaetano Silvia , Ponzo Elena , Biondo Carmelo
Published: September 2023

Antibiotics have played a crucial role in the reduction in the incidence of TB globally as evidenced by the fact that before the mid-20th century, the mortality rate within five years of the onset of the disease was 50%. The use of antibiotics has eliminated TB as a devastating disease, but the challenge of resistance to anti-TB drugs, which had already been described at the time of the introduction of streptomycin, has become a major global issue in disease management. Mismanagement of multidrug-resistant tuberculosis (MDR-TB) cases, resulting from intermittent drug use, prescription errors, and non-compliance of patients, has been identified as a critical risk factor for the development of extensively drug-resistant tuberculosis (XDR-TB). Antimicrobial resistance (AMR) in TB is a multi-factorial, complex problem of microbes evolving to escape antibiotics, the gradual decline in antibiotic development, and different economic and social conditions. In this review, we summarize recent advances in our understanding of how Mycobacterium tuberculosis evolves drug resistance. We also highlight the importance of developing shorter regimens that rapidly reach bacteria in diverse host environments, eradicating all mycobacterial populations and preventing the evolution of drug resistance. Lastly, we also emphasize that the current burden of this ancient disease is driven by a combination of complex interactions between mycobacterial and host factors, and that only a holistic approach that effectively addresses all the critical issues associated with drug resistance will limit the further spread of drug-resistant strains throughout the community.
Paint, Colour, and Style: The Contribution of Minerals to the Palette of the Descent from the Cross, Attributed to the Portuguese Painter Francisco João (act. 1558–1595)
Authors: Melo Helena , Cruz António , Sanyova Jana , Valadas Sara , Cardoso Ana
Published: September 2023

The paint materials and techniques of The Descent from Cross, a panel painting attributed to the Portuguese painter Francisco João (act. 1558–1595), were investigated with a combination of visible, ultraviolet, and infrared imaging and an analysis of paint samples with microscopic, spectroscopic, and chromatographic techniques. The colour palette is composed of lead white, lead–tin yellow, minium, vermilion, ochres of different colours, umber, smalt, azurite, verdigris, charcoal black, and a variety of different-coloured red lakes made of brazilwood and cochineal. An oil-based medium was identified. The characterisation of the pigment mixtures, paint build-up, and particular paint handling techniques enabled us to determine their role in the style and formal appearance of this painting and to discuss Portuguese painting practices in the larger context of 16th-century European painting. Mineral and elemental associations or impurities in the blue pigments, as well as degradation issues affecting minium, and smalt paints were reported. In particular, the deterioration of the glass matrix in some of the smalt particles mixed in lead white paint raises special concern.
Mineralization and Skarn Formation Associated with Alkaline Magma Chambers Emplaced in a Limestone Basement: A Review
Authors: Knuever Marco , Mele Daniela , Sulpizio Roberto
Published: September 2023

The emplacement of shallow magma chambers within a carbonate basement is a typical feature of many volcanic systems around the world. The accompanying formation of exoskarns, endoskarns, cumulates, exsolved fluids and differentiated melts at the interface between the magma chamber and carbonate host-rock is well documented through mineralogical and geochemical studies of ejected skarns and cumulates and through fluid and melt inclusion studies. This review presents the current knowledge on the interaction of alkaline magma chambers with carbonate-bearing host-rocks, with a focus on the geochemical evolution and mineralization at the outer margins of the magma chamber and the accessory mineral phases at Somma-Vesuvius, Colli Albani and Merapi volcanic systems. Furthermore, we discuss how this interaction and its products, especially the CO2 released during the thermometamorphic decarbonation of the carbonate host-rock, impacts the eruptive behavior in all three systems.
The Effects of Ball-Mill Grinding Parameters on Lignite Morphology
Authors: Guven Onur , Ehsani Arman , Kaymakoğlu Burçin
Published: September 2023

In recent years, because of the decreasing liberation sizes of the minerals, processes such as grinding need to be evaluated in more detail. As is well known, size reduction processes are very important both in mineral processing and in many industrial applications. However, to increase the efficiency of the processes after size reduction, variations in particle morphology should also be evaluated, along with particle size. Although the effectiveness of grinding media (ball, rod, autogenous) has been shown for different materials, there are very few studies on the effect of the powder/grinding media ratio and grinding time on particle morphology in terms of shape factor and roughness values. This study aims to investigate the variations in the morphology of lignite samples under different grinding conditions such as grinding time and powder/grinding media ratio (U). The results of these analyses showed that while the d80 size of the ground lignite was 1.1 mm after 2 min grinding time, it decreased to 0.5 mm following 15 min grinding time. The roundness values of particles vary in the range of 0.746–0.790 with increasing grinding time. In addition to the grinding time, while the roundness of particles was found to be 0.739 for 0.34 U values (powder/grinding medium rate), it increased to 0.788 when the U value was adjusted to 0.67. The average roughness (Ra) values of particles increased from 60.9 nm to 107.9 nm upon increasing the grinding time from 2 min to 16 min. Due to these findings, it can be suggested that lignite samples became rounder with increasing grinding times, and roughness analyses made in a 10 × 10 μm surface area with an Atomic Force Microscope (AFM) indicated that particle roughness increased in direct proportion to grinding time.
Ceramic Grinding Kinetics of Fine Magnetite Ores in the Batch Ball Mill
Authors: Yuan Chengfang , Wu Caibin , Ling Li , Yao Xin , Li Zheyang , Xie Feng , Tian Jingkun
Published: September 2023

Aiming to reveal the kinetic characteristics of ceramic ball grinding of fine magnetite comprehensively, two types of ceramic balls ground with the same filling rate and total weight as steel balls were researched. The results show that the breakage rate of ceramic ball grinding is only half of that of steel ball grinding with the same media filling rate. With the same total media weight and a feed size less than 0.212 mm, the breakage rate of the ceramic ball grinding approaches the steel ball grinding and is 17.14% higher than that of the steel ball grinding. The main crushing form of magnetite changed from impact to abrasion in ceramic ball grinding compared with steel ball grinding, which significantly affected the value of the zero-order output constant a. The shift indirectly led to a very different character of the variation ing the parameter β, related to the fines generation rate in the cumulative distribution function of the ceramic ball grinding compared to the steel ball grinding. Therefore, ceramic grinding with a high ball-filling rate can greatly save on energy consumption under the premise of meeting normal production.
Zircon U-Pb Ages, Petrogenesis, and Tectono-Magmatic Evolution of Late Jurassic–Early Cretaceous S-Type Granitoid in Wujinshan Area of Northwestern Zhejiang, South China
Authors: Siddique Uzair , Zeng Zhijie , Zhang Fangjun , Farhan Muhammad , Wang Chengliang , Xia Qijun , Gao Xiang , Zhang Kunlun , Gao Qin , Li Zilong
Published: September 2023

Northwest Zhejiang area (NWZJ) is one of the important parts of the large Qingzhou-Hangzhou mineralized belt in South China formed during the Late Jurassic–Early Cretaceous period. Through the study of zircon LA-ICPMS U-Pb dating, whole-rock geochemistry, and Sr-Nd isotopes for the Wujinshan granitoid in NWZJ, two distinct S-type granitic rocks of porphyry type granodiorite and granite were identified, and the two ages of 146.4 ± 1.5 Ma for granodiorite porphyry and 141.9 ± 1.4 Ma for granite porphyries were obtained. These rocks exhibited a geochemical affinity for S-type granitoid, and the two magmatic ages indicate that these rocks were intruded in two magmatic pulses. The Late Jurassic granodiorite porphyry showed moderate SiO2 (64.38–67.89 wt.%) with higher K2O + Na2O (6.22–6.78 wt.%), lower K2O/Na2O (0.57–0.96), moderate Zr (170–215 ppm), high Sr (302–475 ppm), and low Mg# (31–32) contents. The Early Cretaceous granite porphyries contained high SiO2 (69.68–74.85 wt.%), variable K2O + Na2O (4.60–6.99), high K2O/Na2O (1.72–23.53), slightly higher Zr (160–255 ppm), variable Sr (25–412 ppm), and very low to intermediate Mg# (13–44). The granodiorites had intermediate ∑REE (149–177 ppm), while granite samples showed moderate to high ∑REE content (147–271 ppm), and both rocks showed negative Eu anomalies (0.18–0.29). We propose that these two rocks were predominantly generated by the partial melting of Mesoproterozoic metamorphic basement and underwent variable degrees of fractionation and evolution. The Late Jurassic granodiorite porphyry was formed by the partial melting of Mesoproterozoic metamorphic basement with slab-derived melts or basaltic lower crust input following fractional crystallization, while the Early Cretaceous granite porphyries were generated by the partial melting of Mesoproterozoic metamorphic basement and crystal fractionation with variable magma mixing and assimilation in the upper crust. Tectonically, the Wujinshan granitoid formed in a volcanic arc setting largely affected by the subduction and slab rollback of the paleo-Pacific Plate.
Interaction of Cerium Oxide Nanoparticles and Ionic Cerium with Duckweed (Lemna minor L.): Uptake, Distribution, and Phytotoxicity
Authors: Liu Yang , Zhao Xuepeng , Ma Yuhui , Dai Wanqin , Song Zhuda , Wang Yun , Shen Jiaqi , He Xiao , Yang Fang , Zhang Zhiyong
Published: September 2023

As one of the most widely used nanomaterials, CeO2 nanoparticles (NPs) might be released into the aquatic environment. In this paper, the interaction of CeO2 NPs and Ce3+ ions (0~10 mg/L) with duckweed (Lemna minor L.) was investigated. CeO2 NPs significantly inhibited the root elongation of duckweed at concentrations higher than 0.1 mg/L, while the inhibition threshold of Ce3+ ions was 0.02 mg/L. At high doses, both reduced photosynthetic pigment contents led to cell death and induced stomatal deformation, but the toxicity of Ce3+ ions was greater than that of CeO2 NPs at the same concentration. According to the in situ distribution of Ce in plant tissues by μ-XRF, the intensity of Ce signal was in the order of root > old frond > new frond, suggesting that roots play a major role in the uptake of Ce. The result of XANES showed that 27.6% of Ce(IV) was reduced to Ce(III) in duckweed treated with CeO2 NPs. We speculated that the toxicity of CeO2 NPs to duckweed was mainly due to its high sensitivity to the released Ce3+ ions. To our knowledge, this is the first study on the toxicity of CeO2 NPs to an aquatic higher plant.
Nano-Biotechnology for Bacteria Identification and Potent Anti-bacterial Properties: A Review of Current State of the Art
Authors: Kaushal Shimayali , Priyadarshi Nitesh , Garg Priyanka , Singhal Nitin Kumar , Lim Dong-Kwon
Published: September 2023

Sepsis is a critical disease caused by the abrupt increase of bacteria in human blood, which subsequently causes a cytokine storm. Early identification of bacteria is critical to treating a patient with proper antibiotics to avoid sepsis. However, conventional culture-based identification takes a long time. Polymerase chain reaction (PCR) is not so successful because of the complexity and similarity in the genome sequence of some bacterial species, making it difficult to design primers and thus less suitable for rapid bacterial identification. To address these issues, several new technologies have been developed. Recent advances in nanotechnology have shown great potential for fast and accurate bacterial identification. The most promising strategy in nanotechnology involves the use of nanoparticles, which has led to the advancement of highly specific and sensitive biosensors capable of detecting and identifying bacteria even at low concentrations in very little time. The primary drawback of conventional antibiotics is the potential for antimicrobial resistance, which can lead to the development of superbacteria, making them difficult to treat. The incorporation of diverse nanomaterials and designs of nanomaterials has been utilized to kill bacteria efficiently. Nanomaterials with distinct physicochemical properties, such as optical and magnetic properties, including plasmonic and magnetic nanoparticles, have been extensively studied for their potential to efficiently kill bacteria. In this review, we are emphasizing the recent advances in nano-biotechnologies for bacterial identification and anti-bacterial properties. The basic principles of new technologies, as well as their future challenges, have been discussed.
Influence of Synthesis Conditions on the Properties of Zinc Oxide Obtained in the Presence of Nonionic Structure-Forming Compounds
Authors: Valtsifer Viktor A. , Sivtseva Anastasia V. , Kondrashova Natalia B. , Shamsutdinov Artem S. , Averkina Anastasia S. , Valtsifer Igor V. , Feklistova Irina N. , Strelnikov Vladimir N.
Published: September 2023

This work investigated the influence of synthesis conditions, including the use of nonionic structure-forming compounds (surfactants) with different molecular weights (400–12,600 g/mol) and various hydrophilic/hydrophobic characteristics, as well as the use of a glass substrate and hydrothermal exposure on the texture and structural properties of ZnO samples. By X-ray analysis, it was determined that the synthesis intermediate in all cases is the compound Zn5(OH)8(NO3)2∙2H2O. It was shown that thermolysis of this compound at 600 °C, regardless of the physicochemical properties of the surfactants, leads to the formation of ZnO with a wurtzite structure and spherical or oval particles. The particle size increased slightly as the molecular weight and viscosity of the surfactants grew, from 30 nm using Pluronic F-127 (MM = 12,600) to 80 nm using Pluronic L-31 (MM = 1100), PE-block-PEG (MM = 500) and PEG (MM = 400). Holding the pre-washed synthetic intermediates (Zn5(OH)8(NO3)2∙2H2O) under hydrothermal conditions resulted in the formation of hexagonal ZnO rod crystal structures of various sizes. It was shown that the largest ZnO particles (10–15 μm) were observed in a sample obtained during hydrothermal exposure using Pluronic P-123 (MM = 5800). Atomic adsorption spectroscopy performed comparative quantitative analysis of residual Zn2+ ions in the supernatant of ZnO samples with different particle sizes and shapes. It was shown that the residual amount of Zn2+ ions was higher in the case of examining ZnO samples which have spherical particles of 30–80 nm. For example, in the supernatant of a ZnO sample that had a particle size of 30 nm, the quantitative content of Zn2+ ions was 10.22 mg/L.
Nursing Care for Stroke Patients: Current Practice and Future Needs
Authors: Babkair Lisa A. , Safhi Razan A. , Balshram Raghad , Safhei Rahaf , Almahamdy Atheer , Hakami Fatimah Hamad , Alsaleh Ali Matouq
Published: September 2023

Background: Stroke is the second leading cause of death and the third leading cause of disability worldwide. Stroke nurses play an important role in the care of patients living with stroke by using best practices and adhering to stroke-management guidelines. This study aims at examining the current nursing practice for stroke patients in Saudi Arabia. Method: A cross-sectional descriptive design was used to collect data from nurses working in the stroke unit and intensive care unit between the period of February and June 2022 using electronic self-administered questionnaires. Results: A convenience sample of 131 nurses who provided care for stroke patients was enrolled. Significant differences in nursing practice were found between the stroke units and the intensive care units regarding the activation of the stroke code, X2 (4, N = 131) = 48.34, p < 0.001; transferring stroke patients to a designated bed, X2 (4, N = 131) = 48.74, p = 0.002; applying the NIHSS, X2 (4, N = 131) = 70.11, p < 0.001; using the modified Rankin scale, X2 (4, N = 131) = 61.24, p < 0.001; providing intervention for neglect syndrome, X2 (4, N = 131) = 44.72, and hemianopsia, X2 (4, N = 131) = 39.22; screening for poststroke depression, X2 (4, N = 131) = 101.59, p < 0.001; assessing for psychosocial needs, X2 (4, N = 131) = 74.44, p < 0.001, and encouraging patients to express their feelings, X2 (4, N = 131) = 58.64, p < 0.001; educating patients and families about stroke prevention, X2 (4, N = 131) = 40.51, p < 0.001. Conclusion: As per the results of the study, there is an urgent need for stroke units run by specialized stroke nurses to provide early stroke management and improve survivors’ outcomes. Structured stroke-care programs are needed to improve nursing practice and meet the international standard of stroke care.