bluuebunny/crossref_metadata_2025 huggingface dataset:
STRUKTUR DAN NILAI-NILAI CERITA RAKYAT KABUPATEN CIREBON DAN PEMANFAATANNYA SEBAGAI BAHAN AJAR DI SMA
Authors: Fadila Akhmad
Published: June 2020

Penelitian ini bertujuan untuk menyusun bahan ajar Teks Cerita Rakyat di SMA/MA. Sehubungan dengan hal tersebut peneliti mencoba mengkaji teks cerita rakyat di wilayah Kabupaten Cirebon yang selanjutnya dikaji berdasarkan struktur dan nilai-nilai, untuk dapat dimanfaatkan sebagai bahan ajar bahasa Indonesia di SMA. Penelitian ini menggunakan metode deskriptif analitis. Metode ini dilakukan dengan cara mendeskripsikan data bahasa yang kemudian disusul dengan analisis. Data yang dikumpulkan melalui penelitian ini adalah data kualitatif berupa deskripsi struktur dan nilai teks cerita rakyat asal-usul desa di Kabupaten Cirebon. Pengumpulan data dilakukan melalui dua tahap. Tahap pertama, dilakukan pengkajian struktur dan nilai-nilai dari sebelas cerita asal-usul desa. Tahap kedua, dilakukan pengkajian terhadap kriteria cerita rakyat untuk pemanfaatannya sebagai bahan ajar. Pemerolehan data dilakukan melalui dokumen buku asal-usul desa di Kabupaten Cirebon yang disusun Disbudpora Pemerintah Kabupaten Cirebon edisi pertama sampai enam dan menggunakan teknik angket untuk ahli materi, guru bahasa Indonesia, dan siswa. Berdasarkan hasil kajian dapat dikumpulkan sebelas cerita rakyat asal-usul desa yang merupakan jenis legenda yang memiliki struktur dan nilai-nilai sesuai dengan Kurikulum 2013. Setelah divalidasi oleh ahli materi dan guru bahasa Indonesia serta diuji coba kepada siswa, bahan ajar teks cerita rakyat Kabupaten Cirebon untuk Kelas Sepuluh Berdasarkan Kurikulum 2013 layak digunakan. Hasil implementasi pada peserta didik kelas X SMA Negeri 1 Gegesik Kabupaten Cirebon dari dokumen Cerita Rakyat Asal-usul desa di Kabupaten Cirebon menunjukkan bahwa bahan ajar yang dikembangkan dapat dipahami. Hal ini dibuktikan dari angket yang menyatakan sangat setuju nilai 30, nilai setuju nilai 64 berarti setuju digunakan. Hasil tes, siswa memeroleh nilai prestasi terendah 81,4 sedangkan tertinggi 98,5 berarti siswa mengetahui dan memahami struktur dan nilai-nilai cerita rakyat.
Dorumburnu Nekropolü (Sillyon Territoryumu / Antalya) Kurtarma Kazısından Çıkan İnsan İskelet Kalıntıları
Authors: YILMAZ USTA N. Damla
Published: June 2020

Antalya ilinin Serik ilçesinde yer alan Dorumburnu Nekropolü’nde yürütülen sondaj ve kurtarma kazılarında Geç Antik Çağ’a tarihlendirilen, kiremit çatma tipinde toplam dokuz mezardan insan iskelet kalıntıları ele geçirilmiştir. Bu çalışmada, ilgili iskeletler antropolojik açıdan incelenmiş ve bulgular literatür eşliğinde tartışılarak değerlendirilmiştir. İskelet serisi toplam dokuz bireyden oluşmakla beraber, yedi bireyin yaş grubu belirlenebilmiştir. Bir çocuğun (4 yaş, ±12ay) bulunduğu toplulukta çocuk ölüm oranı %14’dür (n: 1/7). Diğer altı bireyin erişkin olduğu belirlenmiştir. Topluluktaki erişkinlerin biri erkek, ikisi kadın olup, üç erişkinin ise cinsiyeti tayin edilememiştir. İskeletlerde patolojik bulgu olarak, bir erişkin erkek bireyin her iki tibia kemiğinin gövdesinde yüksek ihtimalle travmanın (kemiği kırmadan) yol açtığı lokal yeni kemik oluşumu gözlemlenmiştir. Bu çalışma, az sayıda bireyden oluşan bir grup iskelet üzerinde gerçekleştirilmiş olmasına karşın, Sillyon Territoryumu’na ilişkin ilk antropolojik bilgileri ortaya koyması açsından önemlidir.
Mallarmé’s Digital Demon
Authors: Lübecker Nikolaj
Published: June 2020

How do Mallarmé’s writings speak to the present? To answer this question, this article establishes a dialogue between one of Mallarmé’s early prose poems, ‘Le Démon de l'analogie’, and texts by the contemporary media theorists Mark Hansen, Steven Shaviro and Eugene Thacker. The article argues that Mallarmé’s poem explores how it feels to be a body modulated by code. The poem puts twentieth-century phenomenology with its focus on human perception under pressure, and instead presents a very contemporary view of individuation (subject-formation) as a process that is both thoroughly bound up with the environment, and difficult to comprehend and unify. In a final section, the article considers ‘Le Démon de l'analogie’ in relation to the poet's dream about le Livre, and suggests that Mallarmé’s work as a whole brings together the utopian and the dystopian tendencies that have marked media studies from their inception, and that continue to characterize our relations to the technological object.
The Law or the Demos? Derrida and Rancière on the Paradox of Democracy
Authors: Hoa Jen Hui Bon
Published: June 2020

Jacques Rancière's theory of democracy shares a great deal with Derrida's. Both view democracy as founded on paradox, define it as the irruption of alterity and, most notably, explain the disjunction between empirical and ideal democracy without recourse to the traditional opposition of the political and the social. Rancière diverges from Derrida, however, in two decisive ways. First, he argues that alterity can be comprehended within the system of democracy, which, therefore, should not be understood as constitutively suspended in a messianic temporality. Secondly, Rancière retains a theory of ‘the people’ as a political agent, while avoiding the metaphysics of an identitarian construction of class. This essay traces out the steps by which Rancière affirms Derrida's deconstruction of the notion that the social is the origin of the political, but derives from it a descriptive model of political subjectivation and agency that Derrida's approach would seem to foreclose.
Morphofunctional change small intestine in patients with ulcer disease
Authors: Lityushkina M. I. , Kozlova L. S.
Published: June 2020

The current course of diseases of the digestive system is characterized by a multi-system pathology. The long-term existence of isolated diseases of the organs of the gastrointestinal tract is impossible: the pathology of some organs of a single functional system affects the development of the pathology of other organs.

Purpose. To study the features of intestinal digestion in patients with peptic ulcer.

Material and methods. 152 patients with peptic ulcer who were hospitalized in the gastroenterological department of Mordovian Republican Clinical Hospital were examined in 2011–2017. The main indicators of intestinal digestion by the activity of intestinal enzymes were studied.

Results. Symptoms of impaired intestinal function are observed in 47 % of patients with peptic ulcer disease. In their development, a violation of membrane hydrolytic processes, which were expressed as a decrease (p < 0.05) in the activity of the main intestinal enzymes of maltase in 74 %, alanine aminopeptidase – 73 %, alkaline phosphatase – 62 %, glycyl-L-leucindipeptidase and protein – 37 % (p < 0.01).

Conclusions. With peptic ulcer, the processes of membrane intestinal digestion are disrupted, which contributes to the development of clinical symptoms of a violation of the basic functions of the small intestine.
Modern risk factors and features of treatment of onychomycosis
Authors: Sakania L. R. , Piruzyan A. L. , Korsunskaya I. M.
Published: June 2020

Onychomycosis is a widespread nail disease caused by dermatophytes, yeast and non‑dermatophytes. Risk factors for the development of onychomycosis can be various somatic conditions, for example diabetes, age, lifestyle features. Often onychomycosis occurs in athletes. According to some reports, 60.7 % of football players have this disease. The reason for the increased risk of developing onychomycosis in athletes is wearing unsuitable shoes, the frequent use of synthetic clothing and sweat‑preserving shoes, and injuries to the nail plates. Preference should be given to systemic therapy. Treatment can take up to 18 months, due to the slow regrowth of a healthy nail plate. Of the systemic drugs, itraconazole is widely used. The drug can be prescribed according to the scheme of pulse therapy, and positive dynamics is observed after 2 months of use.
Effect of sotalol on heart rate variability in patients with atrial fibrillation (clinical observation)
Authors: Popova E. P. , Bogova O. T. , Puzin S. N. , Sychyov D. A. , Fisenko V. P.
Published: June 2020

Spectral analysis of heart rate variability gives an idea of the role of the autonomic nervous system in the regulation of chronotropic heart function. This method can be used to evaluate the effectiveness of drug therapy. Drug therapy should be carried out taking into account the individual clinical form of atrial fibrillation. Information about the vegetative status of the patient will undoubtedly increase the effectiveness of treatment. In this study, spectral parameters were studied in patients with atrial fibrillation. The effect of sotalol on the spectral parameters of heart rate variability was studied.
Thermography of periodontal tissues in patients with partial tooth loss before and after orthopedic treatment
Authors: Zhulev E. N. , Arkhangelskaya E. P.
Published: June 2020

The article is devoted to the study of the condition of periodontal tissues in patients with diagnoses of ‘defect of hard tissue of teeth’ and ‘partial loss of teeth’ before and after orthopedic treatment using the method of thermography. The method of infrared thermography has such qualities as high information content, non-invasive research, ease of use, objectivity and complete safety. 50 patients were examined before and after prosthetics with fixed prostheses and 30 subjects of the control group with an intact periodontium. As a result of the study, data were obtained that led to the conclusion that orthopedic treatment of patients with periodontal diseases favorably affects the state of periodontal tissues, reducing inflammation, as evidenced by a decrease in thermography values after treatment.
Role of pregravid body mass and its gestational increase in development of various variants of preeclampsia
Authors: Pokusaeva K. B. , Krivenko A. S. , Katkova N. Yu. , Pokusaeva V. N. , Vakhrushin A. S.
Published: June 2020

Aim. To evaluate the effects of maternal pre-pregnancy body weight and excessive gestational weight gain (GWG) on the risk of different subtypes of preeclampsia (PE).

Methods. A cohort study of 289 pregnant women: 41 with early-onset (less than 34 weeks) preeclampsia (EPE), 76 with late-onset (more than 34 weeks) preeclampsia (LPE) and 172 normotensive women (control). Associations between anthropometric indicators (pre-pregnancy BMI, GWG, fat mass in the 1st, 2nd, 3rd trimesters, on the 2–3rd day after birth) and risk of PE and its subtypes were evaluated.

Results. Pre-pregnancy body weight (r = 0.36; р = 0.000) and BMI (r = 0.38; р = 0.000) moderately increased risk of PE. GWG had independent risk of developing PE (r = 0.46; р = 0.000). Women with excessive GWG had an increased risk of PE in normal BMI (RR = 2.2; р = 0.019), in overweigh (RR = 2.7; р = 0.028), in obese (ОР = 5.2; р = 0.000). The risk of developing preeclampsia increased in normal weight with GWG more than 500 g per week in the 2nd trimester (р = 0.000) and more than 400 g per week in the 3d trimester (р = 0.000), total GWG more than 16.5 kg increased risk of preeclampsia in 3.4-fold (ОР = 3.4; р = 0.001). Overweight and obesity had an increased risk of late-onset preeclampsia (RR = 4.9; р = 0.000). No association was found for early-onset preeclampsia (p > 0.050). Gestational metabolic disorders were independent risk of LPE: weekly GWG and the per cent of fat mass in normal weight pregnant women with LPE were significantly higher compared to the women with EPE and control. The per cent of fat mass in the 1st trimester in PPE (23.90 ± 4.40 %) exceeded control (20.50 ± 4.30 %; р = 0.003) and EPE (21.20 ± 3.65 %; р = 0.008) groups. Differences were aggravated during pregnancy (р < 0.050).

Conclusions. Pre-pregnancy overweight and obesity, excessive GWG and gain of fatty mass were an independent risk of developing PE with synergistic negative effect. Pre-pregnancy and gestational lipid dismetabolism were associated with LPE. Our results suggested that no correlation between pre-pregnancy BMI, GWG, fatty mass and risk of EPE.
Orphan receptor ROR1 for detection of minimal residual disease in chronic lymphocytic leukemia
Authors: Mirolyubova Yu. V. , Timofeeva N. S. , Bart V. A. , Solovyov V. M. , Tolstopyatova E. V. , Fetisov E. S. , Strugov V. V. , Zaritsky A. Yu. , Vavilova T. V.
Published: June 2020

Background and Aims. The detection of minimal residual disease (MRD) of chronic lymphocytic leukemia (CLL) using multicolor flow cytometry has been widely used in clinical studies to evaluate the effectiveness of treatment. The method is being improved by searching for the most sensitive and specific markers for use in panels for 6–8 color cytometers. According to published data, ROR1 shows high expression on CLL cells, and lack of expression on mature lymphocytes, which distinguishes it from other markers used to detect MRD in CLL.

Aim: to determine a significance of ROR1 for detection of MRD CLL by flow cytometry in a 4-color panel.

Materials and Methods. We analyzed 64 bone marrow samples of 37 patients with a verified diagnosis of CLL after the 3rd and 6th cycles of therapy according to bendamustine and rituximab (BR) regimen – 15 MRD-negative and 49 MRD-positive. Quantitative determination of MRD was carried out by the standardized method of 4-color flow cytometry according to the recommendations of ERIC (European research initiative on CLL) with the inclusion of ROR1 in the diagnostic panel. A discriminatory analysis of the differentiating properties of diagnostic markers was performed using Statistica 10.

Results. ROR1 has demonstrated high differentiating properties on CLL cells and mature lymphocytes. All the analyzed samples showed a bright monomorphic expression of ROR1 on CLL cells and B-cell precursors, and the absence of its expression on mature lymphocytes.

Conclusion. ROR1 is a highly specific and sensitive marker for the detection of CLL cells among mature lymphocytes. The high expression of ROR1 on normal B-cell precursors requires the use of ROR1 in combination with a marker that differentiates CLL cells from progenitor cells (CD81).
Clinical significance and features of laboratory determination of vitamin D
Authors: Drygina L. B.
Published: June 2020

The classic function of vitamin D is to regulate calcium metabolism. Currently, however, convincing data have been obtained on the relationship of vitamin D deficiency with the development of a number of diseases. The article analyzes the results of recent studies that present the effects of vitamin D on the immune system, cardiovascular system and liver diseases. Discusses the mechanisms of admission of vitamin D in the body, presents new data on the regulation of levels of active form of vitamin D phosphatonins (FGF23, MEPE, sFRP-4) and protein Klotho. The characteristic of methods of determination of vitamin D in blood serum is presented. Biological factors that influence the results of quantitative determination of vitamin D with different methods are considered separately.
Genetic predisposition and resistance to certain infectious diseases. II. Sexually transmitted infections
Authors: Scherbo S. N. , Shcherbo D. S. , Tishchenko A. L. , Savina M. I. , Turkina T. I.
Published: June 2020

The review addresses issues related to genetic predisposition and resistance to sexually transmitted infections (STI). Genetic factors largely determine the susceptibility of the body to various diseases, including infectious ones. The main influence is given to the genes of the main histocompatibility complex and toll-like receptors. Some STI and genetic polymorphisms responsible for resistance and susceptibility to infections and related clinical consequences are considered. Knowledge of molecular genetic biomarkers is necessary to identify risk groups, conduct predictive measures, in particular vaccination.
Laboratory monitoring analysis and prospects for using its results in specialized clinical diagnostic laboratory
Authors: Bibikova V. V. , Emanuel V. L.
Published: June 2020

This article presents a retrospective analysis of the laboratory monitoring orders from the specialized clinical laboratory. It has been established that large amounts of information about rare, poorly understood diseases and special types of pathology are accumulated during the everyday activity of specialized clinical laboratory. This research indicated that the share of laboratory monitoring, with 17 % of all orders, has a tendency to increase, which may be associated with the improvement of laboratory diagnostic methods. The possibility of laboratory monitoring results using in order to facilitate diagnostic process by the means of an optimal examination algorithm compiling, as well as to study regional pathology, is discussed. Besides, the prospects of using information on laboratory monitoring in improving the organization of specialized clinical laboratory’s activity are assessed.
High sensitivity measurement of cardiac troponins: algorithms, interpretations, clinical consequences
Authors: Velkov V. V.
Published: June 2020

Review of current trends in the usage of high sensitive troponins (hsсTn) in cardiology and emergency medicine. The special attention is given to analytical characteristics of different hscTn tests and algorithms of their serial measurements using for diagnostics of different types of myocardial infarctions, non-ischemic myocardial injury, stable and unstable angina, heart failure, cardiomyopathy takotsubo; myocardities, endocardities, and pericardities. Also it is reviewed the usage of hscTn testing for evaluation of cardiac injuries in patients with sepsis, pneumonia, renal pathologies, stroke, in critical and hospitalized patients, in outpatients and in general population.
MicroRNA and their role in pathogenesis and diagnosis of breast cancer
Authors: Ryabchikov D. A. , Vorotnikov I. K. , Talipov O. A. , Chulkova S. V. , Loginov V. I. , Snegovoy A. V. , Vinokurov M. S. , Kazakov A. M. , Khagazheeva M. N. , Berdova F. K.
Published: June 2020

This article discusses the mechanisms of the influence of microRNAs on carcinogenesis in breast cancer (breast cancer), their potential role as markers for the early detection, prognosis and effectiveness of breast cancer treatment. Epigenetic mechanisms of regulation of miсroRNA expression and their indirect effect on the pathogenesis of the disease are described.
Possibilities of ultrasound examination of chronic venous diseases by classes
Authors: Balakina I. V. , Federov A. P. , Temnikov V. A.
Published: June 2020

Ultrasound diagnostics used in the study of chronic venous diseases (CVD), allows you to visualize the anatomical structure of the veins of the lower extremities, the state of the valve apparatus, the spread of venous refluxes, as well as pathological processes in the lumen of the veins. The use of elastometry techniques, panoramic ultrasound scanning of the lower leg tissues made it possible to obtain objective signs of HZV and supplement the protocol of ultrasound examination of patients.
Din Kültürü ve Ahlak Bilgisi Dersinin Assure Modeline Göre Tasarımı
Authors: Aybey Salih
Published: June 2020

Yeni bilgi ve teknolojilere ulaşılmasıyla birlikte, eğitim-öğretim alanında kullanılan yöntem ve tekniklerde de değişimler yaşanmıştır. Yeni bir öğretim tasarım modeli olarak nitelendirilen ve düzenlenen öğretim programlarının daha verimli, daha etkili ve daha kalıcı olması amacıyla geliştirilen modellerden birisi de “ASSURE Modeli”dir. Bu çalışmada, ASSURE modelinin din eğitimi ve öğretiminde de kullanılabilirliğini ortaya koymak hedeflenmiştir. Bu amaçla ortaokul 5. sınıf ve lise 12. sınıf Din Kültürü ve Ahlak Bilgisi (DKAB) ders kitaplarının ilk ünitelerinin ilk konuları olan “Allah İnancı” ve “İslam ve Bilim” ünitesi/konusu örnek uygulama olarak verilmiştir. Böylece öğrencilerin öğrenme güçlüklerinin giderilmesinde etki ve verimi arttırıcı özelliği bulunan bu modeli öğretmenlerin din eğitimi ve öğretiminde kullanmaları sağlanmak istenmiştir. Öğrenenlerin karakteristik özelliklerinin belirlenerek, arzu edilen öğretim hedeflerine uygun yöntem, medya ve materyalleri seçerek ve kullanarak verimi artırmayı hedefleyen bu modelin, din eğitimi ve öğretiminde kullanılması bu alana yeni bir bakış açısı ve hizmette verimlilik getirecektir.
White-Collar Play: Reassessing Managerial Sports Games
Authors: Buehler Branden
Published: June 2020

In recent years, sports media has become fixated with the act of management, with once-anonymous front office executives increasingly positioned as the new heroes of the sports world. Nowhere is this fixation more evident than in new media texts. Popular sports game franchises like Football Manager emphasize mundane administrative duties rather than action, while countless fantasy sports sites encourage players to carefully manage virtual rosters of athletes. Although sports media’s managerial turn has thus far attracted little scholarly attention, a tentative consensus has begun to emerge around a few of these managerial sports games, with several scholars of sport arguing these games reinscribe troubling inequalities and signal another worrying advance of neoliberal logic – positioning athletes as resources to be optimized and figuring the world as a neatly calculable dataset. As this article argues, though, this emerging understanding of managerial sports games is incomplete. Rather than solely viewing managerial sports games as pernicious incubators of late capitalist logic, we might also consider how these games can precipitate pleasure and critique. As this article suggests, the affordances of managerial sports games uniquely complicate the divisions between work and play. As such, these games invite users to reflect on their relationship to their labor – a process that may allow users to gain a unique sense of empowerment and, moreover, to potentially scrutinize the conditions in which they work.
On the Metaphysics of Rationalism and the Distinction between Ideas and Qualities
Authors: Kader Thomas
Published: June 2020

The rationalists believe that truth is a sufficient condition of thinking itself. This is an action of inference that suggests ideas are contingent on logical conceptions represented by other minds and the qualities of objects. In this view, mind is an interpreter of sensory data that contains observable effects. Consequently, there are demonstrative modes of action in ideas that exist as beings in themselves. There are intentional structures that provide reasons about why ideas are not of the same nature as beliefs because of interpreted representations. Induction is a mode of inference that shows reasons why innate awareness is dependent on the knowledge of logical relations. Thus, the mind has perceivable structures that cause the association of ideas to be part of future and unknown possibilities of justified beliefs.
LAPAROSCOPY WITHIN MULTIMODAL OPTIMIZATION PROGRAMM IN PATIENTS WITH COLORECTAL CANCER
Authors: Zitta D. V. , Subbotin V. M.
Published: June 2020

AIM to assess the efficacy of combination of laparoscopy and protocol of enhanced recovery in patients with colorectal cancer. MATERIALS AND METHODS. Between 2008-2016 466 patients were randomly allocated into 3 groups. Of them 266 of received perioperative treatment according to enhanced recovery protocol, 191 had routibne open procedure (group 2) and, 75 had laparoscopic operation (group 1). Patients underwent the following procedures: right hemicolectomy (n=53), left hemicolectomy (n=32), sigmoidectomy (n=55), abdomeno-perineal excision (n=67) and low anterior resection of rectum(n=201), other operation - 58. The following variables were analized: operating time, intraoperative blood loss, time of first flatus and defecation, morbidity (wound infections, anastomotic leakage, peritonitis, postoperative ileus, urinary disorders, thrombosis, cardiopulmonary complications). RESULTS. Groups were comparable in gender, comorbidities, body mass index, types of operations. Operating time did not differ significantly between 3 groups. Intraoperative blood loss was higher in conventional group. The time offirstflatus and defecation were better in group 1 and 2. Mortality rate was similar. Morbidity was lower in group 1 and 2 compared with conventional group: wound infections 1,3%, 3,1% vs 9%, anastomotic leakage 4%, 5,5% vs 9%, ileus 1,2 vs 5,4%, peritonitis 2,6%, 1,5% and 3,5%, bowel obstruction caused by the adhesions 0%, 6,8% vs 5,5%. Reoperation rate was 4%, 4,7% vs 5,5%, consequemntly. CONCLUSION. Combination of laparoscopic surgery withenhanced recovery program provides better results of treatment.
POST-TRAUMATIC ANAL SPHINCTER INSUFFICIENCY
Authors: Muravyev A. V. , Linchenko V. I. , Muravyev K. A. , Chumakov P. I. , Petrosyans C. І. , Overchenko D. B. , Galstyan A. S. , Efimov A. V.
Published: June 2020

AIM. To develop tactics of treatment for post-traumatic anal sphincter insufficiency in emergency surgery. MATERIALS AND METHODS. 472 patients with anal sphincter insufficiency were treated between 1977-2015. Of them 125 had conservative therapy. Surgical treatment was performed in 347 patients. Twenty-four patients had emergency procedure. RESULTS AND CONCLUSIONS. The success of the rehabilitation of these patients depends on the timely and adequate surgical care at the time of the sphincter injury. 3 degrees of perineum tears in labor should be sutured by experienced obstetricians and only in layers. Sphincteroplasty without colostomy is indicated within 24 hours after injury, while later admission ot hospital requires defunctioning stoma. Gunshot sphincter damage require wound debridement without sphincteroplasty and defunctioning stoma.
EXPERIENCE OF SURGICAL TREATMENT OF COLORECTAL CANCER WITH LIVER METASTASES
Authors: Cherkasov M. F. , Dmitriev A. V. , Groshilin V. S. , Pomazkov A. A. , Starcev Y. M. , Melikova S. G.
Published: June 2020

AIM. To compare results surgery ofcolorectal cancer with resection or radiofrequency thermoablation of liver metastasesi. MATERIALS AND METHODS. Fifty seven patients were included into study. In first group (n=24) liver resection was performed simultaneously with primary tumor surgery; in the second group (n=33) patients underwent local thermal destruction of metastases. RESULTS. Postoperative complications developed in 2 (8,3%) patients of group I and 4 (12,1%) in group II. In group II, the postoperative in-hospital mortality rate was 5,8% (2 patients) due to failure of colonic anastomosis withfecal peritonitis. The disease-free period in group I was 14,4±3,2 months. The 3-year survival rate was 39%, with the median survival of 32,5 months. In group II, the 3-year survival rate was 27%. CONCLUSION. Resectable liver metastases should undergo resection, if there are no adverse factors. This study shows that liver resection is a more effective treatment than radiofrequency thermoablation.
APPLICATION OF FECAL TRANSPLANTATION IN THE TREATMENT OF NO-CLOSTRIDIA ANTIBIOTIC-ASSOCIATED COLITIS
Authors: Zakharenko A. A. , Suvorov A. N. , Shfyk I. V. , Trushin A. A. , Ten O. A. , Smirnov A. A. , Belyaev M. A. , Blinov E. V. , Natha A. S. , Bagnenko S. F.
Published: June 2020

This observation from practice shows modern possibilities of diagnostics and treatment of antibiotic associated gut infection in patient with cancer.
Adrenoleukodystrophy Newborn Screening in the Netherlands (SCAN Study): The X-Factor
Authors: Barendsen Rinse W. , Dijkstra Inge M. E. , Visser Wouter F. , Alders Mariëlle , Bliek Jet , Boelen Anita , Bouva Marelle J. , van der Crabben Saskia N. , Elsinghorst Ellen , van Gorp Ankie G. M. , Heijboer Annemieke C. , Jansen Mandy , Jaspers Yorrick R. J. , van Lenthe Henk , Metgod Ingrid , Mooij Christiaan F. , van der Sluijs Elise H. C. , van Trotsenburg A. S. Paul , Verschoof-Puite Rendelien K. , Vaz Frédéric M. , Waterham Hans R. , Wijburg Frits A. , Engelen Marc , Dekkers Eugènie , Kemp Stephan
Published: June 2020

X-linked adrenoleukodystrophy (ALD) is a devastating metabolic disorder affecting the adrenal glands, brain and spinal cord. Males with ALD are at high risk for developing adrenal insufficiency or progressive cerebral white matter lesions (cerebral ALD) at an early age. If untreated, cerebral ALD is often fatal. Women with ALD are not at risk for adrenal insufficiency or cerebral ALD. Newborn screening for ALD in males enables prospective monitoring and timely therapeutic intervention, thereby preventing irreparable damage and saving lives. The Dutch Ministry of Health adopted the advice of the Dutch Health Council to add a boys-only screen for ALD to the newborn screening panel. The recommendation made by the Dutch Health Council to only screen boys, without gathering any unsolicited findings, posed a challenge. We were invited to set up a prospective pilot study that became known as the SCAN study (SCreening for ALD in the Netherlands). The objectives of the SCAN study are: (1) designing a boys-only screening algorithm that identifies males with ALD and without unsolicited findings; (2) integrating this algorithm into the structure of the Dutch newborn screening program without harming the current newborn screening; (3) assessing the practical and ethical implications of screening only boys for ALD; and (4) setting up a comprehensive follow-up that is both patient- and parent-friendly. We successfully developed and validated a screening algorithm that can be integrated into the Dutch newborn screening program. The core of this algorithm is the “X-counter.” The X-counter determines the number of X chromosomes without assessing the presence of a Y chromosome. The X-counter is integrated as second tier in our 4-tier screening algorithm. Furthermore, we ensured that our screening algorithm does not result in unsolicited findings. Finally, we developed a patient- and parent-friendly, multidisciplinary, centralized follow-up protocol. Our boys-only ALD screening algorithm offers a solution for countries that encounter similar ethical considerations, for ALD as well as for other X-linked diseases. For ALD, this alternative boys-only screening algorithm may result in a more rapid inclusion of ALD in newborn screening programs worldwide.
Enhanced Hyperbox Classifier Model for Nanomaterial Discovery
Authors: Janairo Jose Isagani B. , Aviso Kathleen B. , Promentilla Michael Angelo B. , Tan Raymond R.
Published: June 2020

Machine learning tools can be applied to peptide-mediated biomineralization, which is an emerging biomimetic technique of creating functional nanomaterials. In particular, they can be used for the discovery of biomineralization peptides, which currently relies on combinatorial enumeration approaches. In this work, an enhanced hyperbox classifier is developed which can predict if a given peptide sequence has a strong or weak binding affinity towards a gold surface. A mixed-integer linear program is formulated to generate the rule-based classification model. The classifier is optimized to account for false positives and false negatives, and clearly articulates how the classification decision is made. This feature makes the decision-making process transparent, and the results easy to interpret for decision support. The method developed can help accelerate the discovery of more biomineralization peptide sequences, which may expand the utility of peptide-mediated biomineralization as a means for nanomaterial synthesis.
Sows-Gilts Stocking Rates and Their Environmental Impact in Rotationally Managed Bermudagrass Paddocks
Authors: Pietrosemoli Silvana , Green James T. , Villamide Maria Jesús
Published: June 2020

Ground cover maintenance and nutrients management are key elements to reduce the environmental impact of outdoor swine production. The objective of this study was to determine the effects of sows-gilts stocking rates on vegetative ground cover and soil nutrient concentrations in rotationally stocked bermudagrass (Cynodon dactylon L. Pers) pastures. Three stocking rates (10, 15 and 25 sows-gilts ha−1) were compared during three 8-week grazing periods. Increasing the stocking rate from 10 to 25 sows-gilts ha−1 decreased the ground cover of the paddocks from 65 to 48%, and increased soil nutrient concentrations (ammonium 47%; nitrate 129%; phosphorus 53%; zinc 84%; and copper 29%).
The Use of a Two-Dimensional Electrical Resistivity Tomography (2D-ERT) as a Technique for Cadmium Determination in Cacao Crop Soils
Authors: Bravo Daniel , Benavides-Erazo Javier
Published: June 2020

Cadmium (Cd) is a non-essential heavy metal naturally occurring in the earth’s crust or due to anthropogenic activity. The presence of this metal in cacao farm soils represents a significant issue as levels are now regulated in products derived from cacao beans (Theobroma cacao L.). Several strategies have been proposed to measure cadmium levels; however, little is known regarding in situ non-destructive and time efficient techniques to analyze Cd contents in both cacao topsoils and subsoils, particularly nearby the root system. Therefore, this research aims to integrate the physical property of soil resistivity to Cd content in cacao soils. Cd hot spots are estimated from resistivity measurements using a two-dimensional electrical resistivity tomography (2D-ERT) technique and correlated to Cd determination using inductively coupled plasma optical emission spectrometry (ICP-OES). To assess the dynamics of soil Cd content the correlation is discussed with other physical chemical parameters of soils (pH, organic matter, Ca, Fe, and P). The study was performed in 27 cacao farms in Colombia. A farm in Santander district proved to have the highest level of Cd using the correlated techniques (2.76 mg·kg−1 Cd and 1815 Ohm·m) followed by farms in Boyacá and Arauca districts (2.6 and 0.66 mg·kg−1 Cd, related to 1616 and 743 Ohm·m, respectively). A high correlation between 2D-ERT and Cd determination (R2 = 0.87) was found. The discussion regarding the soil parameters analyzed suggests that the 2D-ERT technique could be used as a preliminary approach to explore Cd distribution in cacao soils.
Boundary Value Problem for Weak Nonlinear Partial Differential Equations of Mixed Type with Fractional Hilfer Operator
Authors: Yuldashev Tursun K. , Kadirkulov Bakhtiyor J.
Published: June 2020

In this paper, we consider a boundary value problem for a nonlinear partial differential equation of mixed type with Hilfer operator of fractional integro-differentiation in a positive rectangular domain and with spectral parameter in a negative rectangular domain. With respect to the first variable, this equation is a nonlinear fractional differential equation in the positive part of the considering segment and is a second-order nonlinear differential equation with spectral parameter in the negative part of this segment. Using the Fourier series method, the solutions of nonlinear boundary value problems are constructed in the form of a Fourier series. Theorems on the existence and uniqueness of the classical solution of the problem are proved for regular values of the spectral parameter. For irregular values of the spectral parameter, an infinite number of solutions of the mixed equation in the form of a Fourier series are constructed.
Human Mesenchymal Stem Cells Overexpressing Interleukin 2 Can Suppress Proliferation of Neuroblastoma Cells in Co-Culture and Activate Mononuclear Cells In Vitro
Authors: Chulpanova Daria S. , Solovyeva Valeriya V. , James Victoria , Arkhipova Svetlana S. , Gomzikova Marina O. , Garanina Ekaterina E. , Akhmetzyanova Elvira R. , Tazetdinova Leysan G. , Khaiboullina Svetlana F. , Rizvanov Albert A.
Published: June 2020

High-dose recombinant interleukin 2 (IL2) therapy has been shown to be successful in renal cell carcinoma and metastatic melanoma. However, systemic administration of high doses of IL2 can be toxic, causing capillary leakage syndrome and stimulating pro-tumor immune response. One of the strategies to reduce the systemic toxicity of IL2 is the use of mesenchymal stem cells (MSCs) as a vehicle for the targeted delivery of IL2. Human adipose tissue-derived MSCs were transduced with lentivirus encoding IL2 (hADSCs-IL2) or blue fluorescent protein (BFP) (hADSCs-BFP). The proliferation, immunophenotype, cytokine profile and ultrastructure of hADSCs-IL2 and hADSCs-BFP were determined. The effect of hADSCs on activation of peripheral blood mononuclear cells (PBMCs) and proliferation and viability of SH-SY5Y neuroblastoma cells after co-culture with native hADSCs, hADSCs-BFP or hADSCs-IL2 on plastic and Matrigel was evaluated. Ultrastructure and cytokine production by hADSCs-IL2 showed modest changes in comparison with hADSCs and hADSCs-BFP. Conditioned medium from hADSC-IL2 affected tumor cell proliferation, increasing the proliferation of SH-SY5Y cells and also increasing the number of late-activated T-cells, natural killer (NK) cells, NKT-cells and activated T-killers. Conversely, hADSC-IL2 co-culture led to a decrease in SH-SY5Y proliferation on plastic and Matrigel. These data show that hADSCs-IL2 can reduce SH-SY5Y proliferation and activate PBMCs in vitro. However, IL2-mediated therapeutic effects of hADSCs could be offset by the increased expression of pro-oncogenes, as well as the natural ability of hADSCs to promote the progression of some tumors.
Preclinical Efficacy and Safety of an Anti-Human VEGFA and Anti-Human NRP1 Dual-Targeting Bispecific Antibody (IDB0076)
Authors: Ko Jong-Hee , Kwon Hyuk-Sang , Kim Bomin , Min Gihong , Shin Chorong , Yang Seok-Woo , Lee Seong Wook , Lee Youngmin , Hong Dahae , Kim Yong-Sung
Published: June 2020

Although bevacizumab (Avastin®) has been approved as an antiangiogenic agent against some cancers, the efficacy is transient and unsatisfactory in other cancers most likely owing to the presence of alternative proangiogenic factors. Therefore, simultaneous blocking of several proangiogenic factors may be a promising strategy for antiangiogenic cancer therapeutics. Accordingly, neuropilin-1 (NRP1) is an attractive target because it serves as a multifunctional receptor for the vascular endothelial growth factor (VEGF) family. Here, we aimed to generate and test an anti-VEGFA and anti-NRP1 dual-targeting bispecific antibody (named as IDB0076) by genetic fusion of an NRP1-targeting peptide to the C-terminus of the bevacizumab heavy chain. Similar to the parental antibody (bevacizumab), IDB0076 suppressed VEGFA-induced migration of human endothelial cells. In contrast, IDB0076 inhibited endothelial-cell migration induced by other angiogenesis growth factors and manifested a more potent antitumor activity than that of bevacizumab in a murine tumor xenograft model. When toxicity was preliminarily evaluated in cynomolgus monkeys, IDB0076 showed no substantial adverse effects, e.g., the absence of noticeable nephrotoxicity, which has previously been documented for the combination therapy of bevacizumab and an anti-NRP1 antibody. Thus, VEGFA-and-NRP1 dual-targeting bispecific antibody IDB0076 may be a potent and safe anticancer agent worthy of further preclinical and clinical studies.
Adenosine-5′-Phosphosulfate- and Sulfite Reductases Activities of Sulfate-Reducing Bacteria from Various Environments
Authors: Kushkevych Ivan , Abdulina Daryna , Kováč Jozef , Dordević Dani , Vítězová Monika , Iutynska Galyna , Rittmann Simon K.-M. R.
Published: June 2020

A comparative study of the kinetic characteristics (specific activity, initial and maximum rate, and affinity for substrates) of key enzymes of assimilatory sulfate reduction (APS reductase and dissimilatory sulfite reductase) in cell-free extracts of sulphate-reducing bacteria (SRB) from various biotopes was performed. The material for the study represented different strains of SRB from various ecotopes. Microbiological (isolation and cultivation), biochemical (free cell extract preparation) and chemical (enzyme activity determination) methods served in defining kinetic characteristics of SRB enzymes. The determined affinity data for substrates (i.e., sulfite) were 10 times higher for SRB strains isolated from environmental (soil) ecotopes than for strains from the human intestine. The maximum rate of APS reductase reached 0.282–0.862 µmol/min×mg−1 of protein that is only 10 to 28% higher than similar initial values. The maximum rate of sulfite reductase for corrosive relevant collection strains and SRB strains isolated from heating systems were increased by 3 to 10 times. A completely different picture was found for the intestinal SRB Vmax in the strains Desulfovibrio piger Vib-7 (0.67 µmol/min × mg−1 protein) and Desulfomicrobium orale Rod-9 (0.45 µmol/min × mg−1 protein). The determinant in the cluster distribution of SRB strains is the activity of the terminal enzyme of dissimilatory sulfate reduction—sulfite reductase, but not APS reductase. The data obtained from the activity of sulfate reduction enzymes indicated the adaptive plasticity of SRB strains that is manifested in the change in enzymatic activity.
Air Contamination in Different Departments of a Tertiary Hospital. Assessment of Microbial Load and of Antimicrobial Susceptibility
Authors: Tselebonis Athanasios , Nena Evangelia , Panopoulou Maria , Kontogiorgis Christos , Bezirtzoglou Eugenia , Constantinidis Theodoros
Published: June 2020

Air contamination in the hospital setting can be a reason for the spread of nosocomial infection among susceptible patients. The aim of this study was to identify bacterial species, and their load and drug resistance, in the air of a tertiary hospital. Air samples were collected on a monthly basis for 12 consecutive months in four different departments of the hospital (Intensive Care Unit (ICU), Internal Medicine Ward (IMW), Surgical Ward (SW), and Neonatal Unit (NU)). In total, 101 samples were collected, out of which 158 Gram-positive (GP) and 44 Gram-negative (GN) strains were isolated. The majority of GP isolates were Staphylococcus spp. (n = 100). The highest total microbial load was reported in the IMW (p = 0.005), while the highest Staphylococcus load was observed in the ICU (p = 0.018). GP bacterial load was higher in autumn, while GN load was higher in spring. Regarding drug resistance, four multi-drug-resistant (MDR) strains and one extensively drug-resistant (XDR) strain were isolated in the ICU, two MDR strains and one XDR strain in the SW, one MDR strain in the IMW and one MDR strain in the NU samples. Air in hospital settings is contaminated with various microbes; some of them are MDR, consisting a potential cause of hospital-acquired infection.
Assessment of Airflow and Oximetry Signals to Detect Pediatric Sleep Apnea-Hypopnea Syndrome Using AdaBoost
Authors: Jiménez-García Jorge , Gutiérrez-Tobal Gonzalo C. , García María , Kheirandish-Gozal Leila , Martín-Montero Adrián , Álvarez Daniel , del Campo Félix , Gozal David , Hornero Roberto
Published: June 2020

The reference standard to diagnose pediatric Obstructive Sleep Apnea (OSA) syndrome is an overnight polysomnographic evaluation. When polysomnography is either unavailable or has limited availability, OSA screening may comprise the automatic analysis of a minimum number of signals. The primary objective of this study was to evaluate the complementarity of airflow (AF) and oximetry (SpO2) signals to automatically detect pediatric OSA. Additionally, a secondary goal was to assess the utility of a multiclass AdaBoost classifier to predict OSA severity in children. We extracted the same features from AF and SpO2 signals from 974 pediatric subjects. We also obtained the 3% Oxygen Desaturation Index (ODI) as a common clinically used variable. Then, feature selection was conducted using the Fast Correlation-Based Filter method and AdaBoost classifiers were evaluated. Models combining ODI 3% and AF features outperformed the diagnostic performance of each signal alone, reaching 0.39 Cohens’s kappa in the four-class classification task. OSA vs. No OSA accuracies reached 81.28%, 82.05% and 90.26% in the apnea–hypopnea index cutoffs 1, 5 and 10 events/h, respectively. The most relevant information from SpO2 was redundant with ODI 3%, and AF was complementary to them. Thus, the joint analysis of AF and SpO2 enhanced the diagnostic performance of each signal alone using AdaBoost, thereby enabling a potential screening alternative for OSA in children.
Can Crude Oil Serve as a Hedging Asset for Underlying Securities?—Research on the Heterogenous Correlation between Crude Oil and Stock Index
Authors: Xu Sa , Du Ziqing , Zhang Hai
Published: June 2020

In the increasingly frequent global financial turmoil, investors prefer to invest in stable assets to hedge risks. Crude oil naturally has dual use value as a general commodity and as a financial asset, which has attracted wide attention. In this paper, we adopt a wavelet coherence analysis to study the standard of crude oil as a hedging asset and analyze the dynamic correlation of crude oil and stock market price fluctuations in the four economies of the United States, Japan, China and Hong Kong at different frequencies. The empirical evidence shows that crude oil can be conditionally used as a hedging asset for underlying securities. From the perspective of space, crude oil is suitable for investors in China’s stock market as a hedging asset, while for stock markets in the US, Japan and Hong Kong, the ability of crude oil to hedge risk has been greatly weakened. From the perspective of investment term, although crude oil cannot be regarded as a hedging asset for long-term investment, it can still play a hedging role in the short term. When the market is in a state of panic, the ability of oil to hedge risk is stronger.
Physical Literacy as A Framework of Assessment and Intervention for Children and Youth with Developmental Coordination Disorder: A Narrative Critical Review of Conventional Practice and Proposal for Future Directions
Authors: Miyahara Motohide
Published: June 2020

A framework of literacy may have roles to play in the assessment and treatment of children and youth with developmental disorders. This review aims to evaluate the conventional practice of assessment and treatment for children and youth with a developmental disorder in the physical domain, called developmental coordination disorder (DCD), and explore how the framework of physical literacy could contribute to the advancement of the current practice. This study adopts a method of narrative critical review based on a non-systematic search for its broad coverage to provide insights into the trend and future alternative directions. Over recent decades, children and youth with DCD have been typically assessed with standardized norm-referenced tests, before and after task-oriented intervention, for aiding diagnosis and evaluating the treatment effect. However, a recent high-quality systematic review showed limited evidence for the treatment effect assessed by the tests. Here, a framework of physical literacy is proposed to be used as an alternative to the conventional practice by recalibrating treatment goals and modifying the assessment and intervention approaches; criterion-referenced real-life authentic assessment and activities are encouraged with an emphasis on the enjoyment of movement and value of physical activity towards the attainment of physically active and healthy lifestyle goals from a lifespan perspective. The application of the physical literacy framework to the assessment and treatment of DCD needs to be further examined conceptually and empirically, while exploring a potential contribution of the literacy framework to transform the conventional assessment and treatment of children and youth with other developmental disorders.