bluuebunny/crossref_metadata_2025 huggingface dataset:
POP1 Facilitates Proliferation in Triple-Negative Breast Cancer via m6A-Dependent Degradation of CDKN1A mRNA
Authors: Zhang Chao , Wang Sifen , Lu Xiuqing , Zhong Wenjing , Tang Yunyun , Huang Weiling , Wu Fengjia , Wang Xiumei , Wei Weidong , Tang Hailin
Published: August 2024

Triple-negative breast cancer (TNBC) is currently the worst prognostic subtype of breast cancer, and there is no effective treatment other than chemotherapy. Processing of precursors 1 (POP1) is the most substantially up-regulated RNA-binding protein (RBP) in TNBC. However, the role of POP1 in TNBC remains clarified. A series of molecular biological experiments in vitro and in vivo and clinical correlation analyses were conducted to clarify the biological function and regulatory mechanism of POP1 in TNBC. Here, we identified that POP1 is significantly up-regulated in TNBC and associated with poor prognosis. We further demonstrate that POP1 promotes the cell cycle and proliferation of TNBC in vitro and vivo. Mechanistically, POP1 directly binds to the coding sequence (CDS) region of CDKN1A mRNA and degrades it. The degradation process depends on the N6-methyladenosine (m6A) modification at the 497th site of CDKN1A and the recognition of this modification by YTH N6-methyladenosine RNA binding protein 2 (YTHDF2). Moreover, the m6A inhibitor STM2457 potently impaired the proliferation of POP1-overexpressed TNBC cells and improved the sensitivity to paclitaxel. In summary, our findings reveal the pivotal role of POP1 in promoting TNBC proliferation by degrading the mRNA of CDKN1A and that inhibition of m6A with STM2457 is a promising therapeutic strategy for TNBC.
Inhibition of ALOX12–12-HETE Alleviates Lung Ischemia–Reperfusion Injury by Reducing Endothelial Ferroptosis-Mediated Neutrophil Extracellular Trap Formation
Authors: Li Chongwu , Gao Peigen , Zhuang Fenghui , Wang Tao , Wang Zeyu , Wu Guodong , Zhou Ziheng , Xie Huikang , Xie Dong , Zhao Deping , Wu Junqi , Chen Chang
Published: August 2024

Lung ischemia–reperfusion injury (IRI) stands as the primary culprit behind primary graft dysfunction (PGD) after lung transplantation, yet viable therapeutic options are lacking. In the present study, we used a murine hilar clamp (1 h) and reperfusion (3 h) model to study IRI. The left lung tissues were harvested for metabolomics, transcriptomics, and single-cell RNA sequencing. Metabolomics of plasma from human lung transplantation recipients was also performed. Lung histology, pulmonary function, pulmonary edema, and survival analysis were measured in mice. Integrative analysis of metabolomics and transcriptomics revealed a marked up-regulation of arachidonate 12-lipoxygenase (ALOX12) and its metabolite 12-hydroxyeicosatetraenoic acid (12-HETE), which played a pivotal role in promoting ferroptosis and neutrophil extracellular trap (NET) formation during lung IRI. Additionally, single-cell RNA sequencing revealed that ferroptosis predominantly occurred in pulmonary endothelial cells. Importantly,
Alox12
-knockout (KO) mice exhibited a notable decrease in ferroptosis, NET formation, and tissue injury. To investigate the interplay between endothelial ferroptosis and NET formation, a hypoxia/reoxygenation (HR) cell model using 2 human endothelial cell lines was established. By incubating conditioned medium from HR cell model with neutrophils, we found that the liberation of high mobility group box 1 (HMGB1) from endothelial cells undergoing ferroptosis facilitated the formation of NETs by activating the TLR4/MYD88 pathway. Last, the administration of ML355, a targeted inhibitor of Alox12, mitigated lung IRI in both murine hilar clamp/reperfusion and rat left lung transplant models. Collectively, our study indicates ALOX12 as a promising therapeutic strategy for lung IRI.
Ulutaş Mahallesinin (İspir/ERZURUM) Botanik Kompozisyonu ve Mera Durumunun Belirlenmesi
Authors: Baykal Hüseyin , Çatal Muhammed İkbal , Bakoğlu Adil
Published: August 2024

2020 yılında Lup metodu kullanılarak Ulutaş mahallesinde (İspir/ERZURUM) yapılan bu çalışmada, toprağı kaplama ve botanik kompozisyon oranları, mera kalite derecesi ve mera durum sınıfı özellikleri incelenmiştir. Araştırma alanında, Poaceae 7, Fabaceae 12 ve diğer familyalarda; Apiaceae 3, Asteraceae 14, Brassicaceae 1, Boraginaceae 2, Campanulaceae 1, Caryophyllaceae 2, Caprifoliaceae 1, Convolvulaceae 1, Euphorbiaceae 1, Hypericaceae 2, Lamiaceae 7, Onagraceae 1, Orobanchaceae 2, Plantaginaceae 2, Polygonaceae 1, Rosaceae 6, Rubiaceae 2 olmak üzere toplam 68 takson tespit edilmiştir. Çalışma yapılan meranın toplam toprağı kaplama oranı %84.75, toprağı kaplama alanına göre botanik kompozisyon oranları Poaceae %14.70, Fabaceae %33.14 ve diğer familyalar %52.16 olarak belirlenmiştir. 3.59 mera kalite derecesi ile meranın durumu “Zayıf” olarak belirlenmiştir.
Comparative characteristics of endovascular occlusion and thoracoscopic amputation of left atrial appendage in patients with atrial fibrillation
Authors: Khalimov Z. Z. , Mamchur S. E. , Mamchur I. N. , Kozyrin K. A. , Bohan N. S. , Sizova I. N.
Published: August 2024

Aim. To compare the effectiveness and safety of endovascular occlusion and thoracoscopic amputation of the left atrial appendage (LAA) in patients with atrial fibrillation (AF).

Methods. We present a retrospective single-center study with a prospective component including 25 patients with AF who underwent thoracoscopic amputation of the LAA and 31 patients on prospective part who underwent endovascular occlusion of the LAA. All patients signed voluntary informed consent for medical intervention and participation in the study. The criteria for selecting patients for thoracoscopic amputation of the LAA were the impossibility of performing an endovascular technique, features of its anatomy and increased trabecularity.

Results. In the group of patients with thoracoscopic amputation of the LAA, 2 cases of embologenic stump of the LAA with a depth of 1.6 cm (8%) were identified; these patients were recommended to continue taking anticoagulant therapy. Among patients who underwent thoracoscopic amputation, no complications were identified in the first 30 days after surgery, including mortality, bleeding, phrenic nerve paresis, acute cerebrovascular accident, pleurisy, pneumothorax, hemothorax. In 3 patients who underwent endovascular occlusion of the LAA, hematomas were detected at the site of puncture of the great vessels (9.7%), in 2 patients thrombus were detected on the occlusion device according to the results of transesophageal echocardiography (6.5%), which required the prescription of warfarin in these patients. Also, in 2 patients (6.5%) during implantation of the occluder into the LAA, as a result of the incorrect diameter of the disk of the occluding device, a residual cavity with a depth of 0.7 cm was formed between the ridge and the occluder. No significant differences in the frequency of non-severe complications were found in the groups, p =0.139. During the year of postoperative observation, thromboembolic complications were absent in the operated patients of both groups.

Conclusion. When comparing two methods of LAA isolation, no severe complications were identified, either in the perioperative or in the early or late postoperative period. There were no significant differences in the incidence of non-severe complications in the early postoperative period. Thus, the effectiveness and safety of thoracoscopic amputation and endovascular occlusion of the left atrial appendage are comparable.
Clinical efficiency and safety of high-power short-duration radiofrequency ablation in treatment of patients with atrial fibrillation
Authors: Fayez A. , Safonov N. V. , Steklov A. S. , Faybushevich A. G. , Farzutdinov A. F.
Published: August 2024

Aim. Evaluation of the clinical efficacy and safety of a high-power short-duration (HPSD) strategy for ablation index (AI) - guided pulmonary vein isolation (PVI) using different power settings.

Methods. 185 patients were scheduled for AI guided ablation. Patients were randomized into 2 groups and every group was divided into two subgroups. First group (n=95) PVI was performed with 50W. Second group (n=90) with 45 W. In Ia and IIa AI was 400-450 au (arbitrary unit) in posterior wall and 500-550 au. in the anterior wall. In Ib and IIb AI was 400-450 au in posterior wall and 450-500 au in the anterior wall.

Results. Efficacy of the PVI was 100% in all patients. Within 6 months, atrial fibrillation recurred in Ia, Ib, IIa and IIb subgroups were 5/55 (9,0%), 4/40 (10%), 6/50 (12%) и 5/40 (12,5%) p >0,05. First-pass PVI in Ia, Ib, IIa and IIb subgroups were 53/55 (96,36%), 37/40 (92.5%), 46/50 (92%), 36/40 (90,5%) (p>0,05). There was no significant intra operative complications. The total procedure time was 55±10 min, 50±8 min, 60±10 min, 56±9 min (p>0,05).

Conclusions. HPSD ablation in patients with atrial fibrillation significantly reduces the procedure time, does not increase the incidence of intraoperative complications and is effective in the short term results.
Familial RBM20-cardiomyopathy: various clinical phenotypes. Case report
Authors: Rimskaya E. M. , Novikov P. S. , Salami H. , Kukharchuk E. V. , Mironova N. A. , Dobrovolskaya S. V. , Shestak A. G. , Zaklyazminskaya E. V. , Golitsyn S. P.
Published: August 2024

Genetic causes are increasingly found to be responsible for the development of sudden death in young people. Since 2009, pathogenic mutations in RBM20 gene were recognized as an important cause of dilated cardiomyopathy (DCM) and sudden cardiac death (SCD). The high risk of malignant ventricular arrhythmias in RBM20-cardiomyopathy has made these patients potential candidates for the implantable cardioverter-defibrillator for primary prevention of SCD. The presented clinical case of malignant pathogenic mutation in the RBM20 gene demonstrates different phenotypes, including DCM, SCD and asymptomatic forms in one family. Moreover, for the first time we described the presence of prolonged QT interval due to the fusion with U wave on ECG in carries of this malignant familial mutation. The prolonged QT interval may contribute to the development of ventricular arrhythmias and the increased risk of SCD in patients with this rare genetic pathology.
Network Forensics Analysis of Cyber Attacks Carried Out Over Wireless Networks Using Machine Learning Methods
Authors: Kaçan İmran , Gül Batuhan , Ertam Fatih
Published: August 2024

As technology advances, the frequency of attacks targeting technological devices has surged. This rise in cyber threats poses a constant risk to the devices we rely on. Any device connected to a network becomes vulnerable to exploitation by attackers. Given the extensive interconnectedness of devices in network environments, this research endeavors to address this pressing issue. The aim of this study is to analyze and classify network traffic generated during potential cyber attacks using various classification algorithms. By subjecting a simulated environment to different cyber attack scenarios, we extract the distinctive features of network packets generated during these attacks. Subsequently, we employ widely used classification algorithms to train and analyze the obtained data. For the comparison of models, more than 7000 attack data instances were employed. At the conclusion of the comparison, the Gradient Boosting algorithm achieved the highest accuracy value, reaching 91%, whereas the Naive Bayes algorithm obtained the lowest accuracy, reaching 74%.
Políticas de memoria sobre el devenir de las sociedades indígenas en la historia regional
Authors:   , Sánchez Azcárate Felicitas
Published: August 2024

En esta investigación nos proponemos indagar sobre el lugar que ha ocupado “lo indígena” dentro de las narrativas dominantes respecto al devenir histórico de la ciudad de Mar del Plata. Buscamos analizar las políticas de memoria acerca del pasado y, particularmente, del pasado indígena, promovidas por el Museo municipal José Hernández y por la réplica de la Reducción jesuítica Nuestra señora del Pilar. Ambos espacios alusivos al devenir local, se encuentran emplazados en la Reserva Integral “Laguna de los Padres”, a unos 14 Km de la ciudad de Mar del Plata. Estos sitios, constituyen un lugar relevante dentro de la oferta turística y cultural marplatense posibilitando comunicar un conjunto de enunciados respecto a los orígenes de la ciudad y a la historia de la región. Abordamos estos dos dispositivos culturales (Agamben 2011) como lugares de memoria (Nora 1984), ya que no solo historizan y divulgan relatos sobre el pasado, sino que también promueven y permiten activar determinadas memorias, recuerdos y/o experiencias compartidas desde el presente. En este sentido, siguiendo los postulados de Michael Pollak (2006), el Museo y la réplica de la Reducción jesuítica funcionan como indicadores empíricos de la memoria colectiva de determinados grupos, una memoria estructurada con sus jerarquías y clasificaciones que, al definir y delimitar lo que es común a un grupo y lo que lo diferencia de los demás, refuerza los sentimientos de pertenencia.
Horizons and Bridges of Dialogue
Authors: Airo Richard Ooko , Kapinde Stephen Asol , Wa Chidongo Tsawe Munga , Muoki Stephen Joshua
Published: August 2024

This research article explores the way in which the Roman Catholic Church (RCC) has brought to life the interreligious principles of the Second Vatican Council (1962-1965), as articulated in its Magna Carta Nostra Aetate (NA), which served as the Church’s official doctrine and stance on its relationship with non-Christian religions and world cultures. The article also delves into the RCC’s interpretation of postconciliar exhortations, including the Papal encyclicals and magisterium, in its religious and social activities to foster community cohesion and peaceful co-existence in Kenya. It explores the theological outcomes of interreligious dialogue and its pastoral practice in the Coastal Kenya. It scrutinizes the RCC’s contribution to religious moderation and social cohesion through its multifaceted dialogue initiatives with the civil society, religious, and corporate communities. It empirically analyzes the numerous initiatives and ambitious development programs, i.e., education and charity, empowerment through conferences, training, and theological exchanges with the religious other. It utilises qualitative and quantitative approaches to gather empirical data from 140 respondents through interviews, Focus Group Discussions (FGDs), and questionnaires. From the empirical data it evaluated the impact and outcome of RCC’s interreligious programs and how dialogue can reshape prevailing stereotypes about other religions in a pluralistic context.
Towards a Dialogic Community
Authors: Airo Richard Ooko , Kapinde Stephen Asol , Wa Chidongo Tsawe Munga , Muoki Stephen Joshua
Published: August 2024

This article sets out to analyse the forms of interreligious dialogue (IRD) adopted by the Roman Catholic Church (RCC) Archdiocese of Mombasa towards the promotion of social cohesion in the Coastlands of Kenya. RCC has been working with local communities in moderation of religious extremism and promoting harmonious interreligious relations. This research article argues that the RCC dialogic models are geared towards creating a dialogic community which is inclusive and cherishes equity over inequality, justice over injustice, peace over violence, and unity over disunity. In an attempt to build such a community, the RCC dialogic models was increasingly influenced by the Vatican II Council (1962-1965) and post-conciliar exhortation including Papal messages and Encyclicals. Thus, RCC took a multidimensional and integrated approach in partnership with other groups both Christian and non-Christians, faith-based and secular towards promoting interreligious dialogue. In a nutshell, it reviews that the four models of dialogue: the dialogue of life, the dialogue of action, the dialogue of religious experience, and the dialogue of theological exchange, adopted by the RCC Archdiocese of Mombasa, from 1983 to 2023. The four dialogical models re-mapped the ground for community development within a frame of ideas, such as friendship and solidarity based on mutuality, hospitality, and reciprocity between different religious groups. It also discusses some of the obstacles the RCC faced in its IRD initiatives. In conclusion, this article provides a contextual analysis of RCC’s pastoral approach and practice of IRD to social cohesion in the Coastlands of Kenya.
Analisis Kebutuhan Pengembangan e-Modul Materi Sel SMA Kelas XI
Authors: Almunawarah Rifka , Ngitung Rosdiana , Bedduside Nurhayati
Published: August 2024

This study focuses on analyzing the needs of learning resources in the form of electronic module (e-module) for high school students in class XI, as a means in the learning process. The purpose of this study was to determine the needs of students for e-module learning resources to be developed. The method used is descriptive qualitative method. The data retrieval technique used in this study was lesson plan observations and surveys, the research instruments used were questionnaires and checklists. The data analysis used is by reducing the data into more specific data to be presented descriptively. The results of the initial observations obtained are that students need electronic learning resources in the form of e-module. Based on this, it is necessary to develop an e-module on cell material that can support the biology learning process in schools.
Penerapan Jurnal Belajar untuk Meningkatkan Keterampilan Bertanya Calon Guru IPA
Authors: Yanto Nurfitra , Ramlawati Ramlawati , Muhiddin St. Mutia Alfiyanti
Published: August 2024

This study aims to determine the increase in questioning skills of prospective science teacher students. This type of research is Classroom Action Research. This research was designed as a classroom action research which consisted of 2 cycles. Each cycle consists of four stages, namely planning, action, observation, and reflection. This research was carried out in the Science Education Study Program, FMIPA UNM and the subjects of this research were students of the Program Studi Pendidikan IPA who took the IPA Sekolah 1 course in the 2022/2023 academic year. The data in this study can be in the form of qualitative data. Qualitative data in the form of learning journals made by students. The learning journal contains material conclusions, interesting things related to the material being taught, questions asked, and temporary answers to questions asked. The questions contained in the study journal are classified based on the Cognitive level of Bloom's Taxonomy and are analyzed quantitatively. In cycle I, student questions were directly answered by the subject lecturer. The results obtained were that the number of students who asked questions C1 was 20, C2 was 51, C3 was 25, C4 was 3, and there were no questions with cognitive levels C5 and C6. In cycle II, the questions posed by students were discussed and discussed by the students themselves, the course lecturer only served as a facilitator, so the number of questions at the cognitive level C1 was 6, C2 was 53, C3 was 11, C4 was 17, C5 was 7. Based on From these results, it can be concluded that the questioning skills of prospective science teacher students have increased.
Peningkatan Hasil Belajar IPA Materi Pencemaran Lingkungan melalui Model Problem Based Learning pada Siswa Kelas VII E SMPN 3 Labakkang
Authors: Taslim Fitriani , Tawil Muh. , Rahman Yenni , Ramlawati Ramlawati
Published: August 2024

Science study result of class VII E students Junior High School 3 Labakkang is still low, it is indicated by only 68% of students had passed the learning in the Mid-test academic year 2020/2021. The study low result is caused by the learning proccesed just used conventional learning model. Therefore, the researcher chose the Problem Based Learning model to solve the problem. The purpose of this research was to improve Science studies learning achievement using the Problem Based Learning Model. This research was a classroom action research with three cycle. Each cycle consist of four steps, they are planning, acting, observing, and reflecting. The subjects of this research were the 25 of class VII E students Junior High School 3 Labakkang. Based on the research result, the study result in cycle I was 50%. It was improve in cycle II. In cycle II 64,29% of students had reach the learning standard. The significant improvement can be seen in cycle III 76,92% of students had reach the learning standard. Analysis of the research results showed that more than 75% of students had reach the learning standard. It may be conclude that Problem Based Learning model could improve the Science studies cognitive learning achievement on environmental pollution of class VII E students Junior High School 3 Labakkang.
Pelatihan Akreditasi Jurnal di Lingkup FMIPA Universitas Negeri Makassar
Authors: Aswi Aswi , Assagaf Said Fachry , Yunus Sitti Rahma , Pratiwi Diana Eka , Sulistiawaty Sulistiawaty , Saleh Andi Rahmat , Fahmuddin Muhammad , Abidin Muhammad Rais , Awi Awi
Published: August 2024

Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberikan workshop mengenai akreditasi jurnal ilmiah kepada para dosen di lingkup FMIPA UNM. Kegiatan ini terdiri dari beberapa tahap yaitu observasi, penyampaian materi, diskusi, angket dan diakhiri dengan monitoring dan evaluasi program. Setelah mengikuti kegiatan workshop, diperoleh hasil bahwa seluruh peserta workshop telah mampu mengetahui syarat-syarat dalam melakukan akreditas jurnal, sekitar 95,2% peserta workshop sudah paham akan mekanisme pengajuan akreditasi jurnal, sekitar 95,3% peserta workshop telah mampu mengetahui tahapan-tahapan dalam melakukan pengajuan akreditasi jurnal, dan sekitar 95 % peserta sependapat bahwa materi sesi 1 sampai sesi 4 yang diberikan sesuai dengan kebutuhan peserta dan materi disampaikan secara sistematik dan jelas. Dengan demikian dapat disimpulkan bahwa kegiatan workshop akreditasi jurnal ini terbilang sukses dilaksanakan dan seluruh peserta mengikuti kegiatan dengan antusias dan memberikan apresiasi yang sangat positifKata Kunci: Pengabdian, Workshop, Akreditasi, Jurnal
Türkiye Koşullarında Alışveriş Merkezi Yatırım Süreci İçin Bir Değerlendirme Modeli Önerisi
Authors: Şahin Diri Berrin
Published: August 2024

Gayrimenkul sektörü Türkiye’de büyük bir potansiyele sahip bir sektördür. Devlet Planlama Teşkilatının verilerine göre gayrimenkul sektörüne yapılan 1 birimlik yatırım genel ekonomide 2.5 katsayılık bir üretim artışına yol açmaktadır. Türk insanı risksiz bir yatırım aracı olarak gördüğü gayrimenkule yatırım yapmayı tercih etmektedir. Ancak depremle birlikte insanların eğilimlerinde değişiklikler yaşanmış ve bu değişikliklerle birlikte gayrimenkul sektörü için yeni ve büyük bir potansiyel oluşmuştur. Türkiye’de ve dünyada alışveriş yatırımının durumu, yatırımcı tipleri özetlenerek sermayesini alışveriş merkezi yatırım sürecine katılarak değerlendirmek isteyen girişimciler için; projeye ait gelecekteki muhtemel nakit akışlarını önceden izleme imkanı veren ve proje karlılığını ölçebilecekleri bir model, süreci özetleyen akış şemalarıyla anlatılmaya çalışılmıştır.
Chronological Analysis of The Ontological Sequence of The Neighborhood in Urban Physical Stratification; Şükran Neighborhood-Konya
Authors: Arat Yavuz , Büyükşahin Süheyla
Published: August 2024

The aim of this study is to understand the change in the spatial structure of Şükran district, which has been shaped by the concept of neighborhood from past to present in the urban memory of Konya. In this context, the stratification in the urban space with the historical stratification, the structure and road relationship that will be revealed together with the ontological structure of the neighborhood, and the evolution of the land subdivision form and situation over the years will be examined in detail. In this sense, the connection of the structure, which is expected to be completely changed in the future with the urban transformation of the neighborhood, which is located in the historical city center of Konya and where mainly dwellings are built, will be questioned and the systematic structure of the transformation will be investigated. As a result, questioning the transformation of urban spaces where the urban physical gradation continues is important in order to transfer urban memory to future generations. In line with these purposes, within the scope of the study, the ontological structure of the neighborhood will be questioned within the urban physical stratification that took place in the historical process, its formation in the city in unplanned and planned periods from the past to the present will be investigated in detail within the framework of the decisions taken by the city administrators and the changing regulations and a documentation will be done at the point of transferring the urban memory to the future.
Sürdürülebilirlik Kapsamında Yeşil İK Yönetimi VE Personel Güçlendirme: İBB Örneği
Authors: Tanyıldızı Hilal , Habip Elif
Published: August 2024

Yeşil insan kaynakları yönetimi kavramı, örgütlerin sürdürülebilirlik hedeflerine ulaşması açısından büyük önem taşımaktadır. Çevre dostu davranışların teşvik edilmesi, kurumların sürdürülebilirlik konusunda daha etkili bir rol oynamasını sağlamaktadır. Bu bağlamda, sürdürülebilirlik hedeflerinde başarıya ulaşmak isteyen örgütler, yeşil insan kaynakları yönetimi ile daha sağlam adımlar atabilmektedir. Bu çalışma kapsamında, İstanbul Büyükşehir Belediyesi (İBB) örneğinde, bu alanda atılan adımlar incelenmiştir. Çalışanların sürdürülebilirlik konusunda güçlendirilmesi, organizasyonun çıkarları için de faydalıdır. Yapılan çalışma sonucunda, İBB’nin sürdürülebilirlik bağlamında artan çabalarının olduğu ve bu çalışmalarda personelin sürece aktif olarak dahil edildiği gözlemlenmiştir. Aynı zamanda bu çalışmalar, iş birliklerine dayalı olarak eğitim, seminer, çalıştay ve çeşitli faaliyetler kapsamında gerçekleştirilmektedir. Tüm birimlerde bu faaliyetlerin uygulanması önerisiyle, yeşil şehir olma yolunda daha güçlü adımlar atılması tavsiye edilmektedir.
BREVES REFLEXÕES SOBRE OS FUNDAMENTOS ONTOLÓGICOS E EPISTEMOLÓGICOS DA BASE NACIONAL COMUM CURRICULAR – BNCC
Authors: Lima Átila de Menezes , França Cristiane Ferreira de Souza , Sena Ivânia Paula Freitas de Souza
Published: August 2024

Desde os anos 1990, constata-se, no Brasil, uma série de reformas curriculares que buscam abrir caminho para a iniciativa privada, num movimento que objetiva mercantilizar a educação pública frente à escalada da agenda neoliberal, que, por sua vez, alia interesses de grupos econômicos, os quais se articulam em várias dimensões, que perpassam do global ao local. Este artigo tem o objetivo de contribuir com reflexões sobre as bases ontológicas e epistemológicas contidas na BNCC, demonstrando o caráter conservador e multiculturalista em seu papel na (re)produção do status quo e na manutenção das desigualdades sociais, pela tentativa de captura da escola, do currículo e do trabalho docente, destacando o papel do Banco Mundial. Para tanto, a metodologia se pautou pelo método materialista histórico e dialético a partir da pesquisa matricial, sob a coordenação da Universidade do Estado da Bahia - UNEB, da Universidade Federal de Alagoas - UFAL e da Universidade Federal da Bahia - UFBA, de caráter nacional que tem como título - “A BNCC no controle da educação pública: mecanismos neoliberais para conter as perspectivas educacionais emancipatórias”. Compreende-se que, se por um lado há uma nova ofensiva do capital em relação à educação, por outro lado, há movimentos contra hegemônicos, seja no campo ou na cidade, que lutam por uma educação pública, gratuita, socialmente referenciada e de qualidade.
Peran Literasi Keuangan Dan Teknologi Keuangan Melalui Inklusi Keuangan Untuk Keberlanjutan Umkm
Authors: Richard Yumiad Fernando , Longgy Dodhy Hyronimus Ama , Epin Maria Natalia Wainip
Published: August 2024

Usaha Mikro, Kecil, dan Menengah (UMKM) memainkan peran penting dalam pembangunan ekonomi dan kesejahteraan sosial di banyak negara. Namun, akses ke peluang keuangan dan pemasaran tetap menjadi tantangan yang terus-menerus bagi perusahaan-perusahaan ini. Kajian ini menggali potensi teknologi digital dalam meningkatkan inklusi keuangan dan strategi pemasaran UMKM untuk mendorong pertumbuhan ekonomi dan stabilitas keuangan. Kajian ini bersifat kuantitatif dengan menganalisis studi kasus, dan menggunakan survei dan wawancara untuk mengumpulkan data dari UMKM di berbagai sektor. Tujuannya untuk mengidentifikasi kesenjangan pembiayaan dan pemasaran saat ini serta menilai dampak adopsi teknologi digital terhadap kinerja dan pertumbuhan UMKM. Sampel ditarik menggunakan teknik accidental sampling. Data dianalisis menggunakan menggunakan analisis multivariat dengan model Partial Least Square (PLS) dengan bantuan software Smart-PLS. Hasil empiris mengungkapkan bahwa hanya terdapat dua hipotesis yang memiliki pengaruh terhadap keberlanjutan bisnis. Edukasi dan inovasi layanan Keuangan berbasis digital perlu terus ditingkatkan sehingga tercipta inklusi Keuangan
Pengaruh Penambahan Limbah Plastik Polietilena Tereftalat (PET) terhadap Karakteristik Marshall dengan Filler Limbah Las Karbit
Authors: Sanjani Ikhwan , Nababan Dewi Sriastuti , Kakerissa Yance
Published: August 2024

Karakteristik marshall merupakan kemampuan suatu campuran aspal untuk menerima beban sampai terjadinya aliran (flow) yang dinyatakan dalam kilogram. Tujuan penelitian ini mengetahui pengaruh penambahan limbah plastik PET (Polyethylene Terepthalate) pada aspal beton AC – WC (Asphalt Concrete-Wearing Course) dengan filler las karbit. Penelitian ini mengunakan metode eksperimental dengan syarat yang telah ditentukan oleh Standar Bina Marga 2018. Cara pencampuran yang digunakan proses basah pencampuran langsung plastik (Polyethylene Terepthalate) ke dalam aspal panas, kemudian ditambahkan agregat. Variasi PET sebesar 3%,7% dan 9% dari berat total aspal. Hasil penelitian pengaruh penambahan plastik PET dengan filler las karbit, dapat mempengaruhi peningkatan dan juga penurunan terhadap karakteristik marshall. Hasil evaluasi volimetrik nilai stabilitas mengalami peningkatan sebasar 0,217%, marshall quotient mengalami peningkatan sebesar 0,088%, flow mengalami penurunan sebesar 0,114%, VIM (Void in Total Mix) mengalami peningkatan sebesar 0,415%, VFA (Void Filled With Asphalt) mengalami penurunan sebesar 0,210% dan VMA (Voids in Mineral Agregat) mengalami penurunan sebesar 0,244%. Dari hasil evaluasi volimetrik menunjukan penggunaan limbah plastik PET dengan variasi 3%,7% dan 9% belum optimal untuk digunakan sebagain bahan tambahan lapisan AC - WC, karena nilai  VIM, VFA dan VMA tidak memenuhi spesifikasi umum Bina Marga 2018.
Spin-wave emission using a V-shaped antenna
Authors: Yoshida Ryota , Nezu Shoki , Sekiguchi Koji
Published: August 2024

We investigated the dynamics of spin waves in micro-patterned Permalloy thin films using time-resolved magneto-optic Kerr effect microscopy (TR-MOKE). By applying an external magnetic field, we observe the field dependence of spin wave signals with picosecond resolution. Fourier transform analysis of the signals confirms their agreement with the dispersion relation, demonstrating the successful detection of propagating spin waves using the MOKE technique. Furthermore, we perform dynamic measurements of interfering spin waves generated by a V-shaped antenna. The experimental results reveal differences in spin wave amplitude at each detection point. In combination with simulation analysis based on wave propagation from the V-shaped antenna, we reproduced the experimental results and revealed the existence of a protective zone.
Gas Turbine Performance Enhancement and Evaluation for Power Generation in the City of Karbala, Iraq
Authors:   Department of Mechanical Engineering, Cross River University, Calabar, Nigeria., Enyia Diwa James , Osim-Asu Dane ,   Department of Mechanical Engineering, Cross River University, Calabar, Nigeria., Uzomah Paul Chibundu ,   Department of Mechanical Engineering, Dynamic and accomplished Field Research Engineering, Calabar, Nigeria., Enyia Stanley James-Diwa ,   Department of Mechanical Engineering, Calabar, Nigeria.
Published: August 2024

The performance of gas turbines is highly susceptible to environmental factors, particularly in arid and hot climates. The present study examines the direct impact of ambient temperature on the gas turbine's performance under the climatic conditions of Karbala city. An Excel proprietary software modeled using the law of energy and mass conservation was used to simulate real data collected from the Karbala power plant (gas turbine). The simulation result was found for the gas turbine power plant with steadily increasing compressor entry temperature (T1). The result show that for a 40K temperature rise from 300K-340K at the compressor inlet stage, net power gained a 13.34% increment; thermal efficiency gained a 13.33% increment and a reduction in the specific consumption of fuel (SFC) by 12% was noticed. The effect was acknowledged to be a resonating one rather than direct. Recommendations suggest that a pre-compressor cooling technology be developed and incorporated with a high efficiency pre-combustor heating technology for compressor reduction and SFC reduction. Best practice.
Metodología activa basado en servicio: Cartilla para docentes
Authors: Jara Ramírez Milton Andrés , Barrada Soto Elizabeth
Published: August 2024

El APS se postula como una metodología que, intercala procesos de enseñanza y aprendizaje, al mismo tiempo que direcciona el conocimiento ya adquirido en la práctica diaria, por medio de un servicio comunitario que, al ser bien estructurado dentro de un proyecto educativo, da como resultado, procesos cognitivos, altruistas y sociales.
ENTRE A POESIA E A HISTÓRIA: VICO E A BUSCA PELO VERDADEIRO HOMERO
Authors: Leite Neto Eduardo
Published: August 2024

A interação entre o direito, filosofia, filologia, história e literatura, proporcionou ao pensamento de Giambattista Vico (1668-1744) o trânsito nas várias disciplinas do conhecimento humano. Nessa articulação multidisciplinar na qual buscava traçar a genealogia da sociabilidade humana, a figura de Homero é destacada pelo autor ao identificar nos poemas homéricos os dois grandes tesouros da gentilidade. No seu opus magnum, a Scienza Nuova, dedica ao terceiro livro ''Sulla discoverta del Vero Omero'' uma análise detalhada acerca dos poemas homéricos e sua relação com as etapas do desenvolvimento do mundo grego, onde busca objetos que comprovem a veracidade histórica de Homero assim como de seus escritos. Portanto, a finalidade deste artigo é descrever o percurso argumentativo usado por Vico para investigar o poeta grego e seus poemas épicos.
ALBERT CAMUS: A RECONFIGURAÇÃO DO MUNDO ATRAVÉS DA ARTE
Authors: Leva Gabriel , Furlan Reinaldo
Published: August 2024

Neste artigo buscamos investigar o papel da arte no pensamento e obra de Albert Camus. Para isso, avançamos em seus principais ensaios: O mito de Sísifo e O homem revoltado, na tentativa de sintetizar suas ideias acerca da criação absurda e da arte revoltada. Consideramos que a criação absurda, pensada n’O mito... sofrerá uma expansão explosiva no segundo ensaio do autor. Se, inicialmente, a arte para Camus devia expressar a fratura do homem e seu mundo, a consciência de nossa própria absurdidade, a arte revoltada revela o movimento inicial de todas as subjetividades humanas: a estilização de um mundo sem sentido. Dessa forma, a criação artística deixa de ser unicamente uma escola de paciência, lucidez e multiplicação diante de uma experiência humana que carece de unidade e sentido, tornando-se a expressão mais proeminente dessa própria condição. O revoltado e o artista compartilham as mesmas exigências, éticas e estéticas, afinal, a própria revolta é, em parte, uma exigência estética. Desse modo, buscamos expor e elucidar os conceitos camusianos em torno da arte, absurda ou revoltada, e seus desdobramentos para uma ética estilizada.
Riesgo de acretismo placentario en pacientes con cesárea previa
Authors: Osorio Sagastume Amanda María
Published: August 2024

PROBLEMA: el acretismo placentario es una anomalía obstétrica la cual conduce a complicaciones maternas graves, cuya incidencia se ha visto aumentada como consecuencia del incremento de cesáreas. OBJETIVO: describir el riesgo de acretismo placentario en pacientes con cesárea previa. MÉTODO: Se realizó una revisión sistemática de artículos médicos para recopilar información, utilizando los términos acretismo placentario y cesárea previa. RESULTADOS: el acretismo placentario consiste en la adhesión e invasión placentaria en el útero, la cual se ha encontrado en aumento en los últimos años de 1:30,000 a 1:333-533 condicionado por el aumento de cesáreas a nivel mundial, su diagnóstico requiere estudio de factores de riesgo y realización de ecografía, el tratamiento de elección es histerectomía.  CONCLUSIÓN: el riesgo de acretismo placentario en pacientes con cesárea previa se debe a las alteraciones anatómicas y químicas que se produce en la cicatriz del útero en embarazos posteriores.
Pengendalian Kualitas Produk X Menggunakan Pendekatan Six Sigma
Authors: Putri Anindita
Published: August 2024

Pengendalian kualitas merupakan aspek kritis dalam dunia manufaktur yang memegang peranan penting dalam menjamin produk yang dihasilkan memenuhi standar mutu yang ditetapkan. Dengan menerapkan sistem pengendalian kualitas yang efektif, produk cacat dapat diminimalisir, memberikan dampak positif terhadap kepuasan pelanggan dan reputasi perusahaan.  Di era industri 4.0, persaingan antar perusahaan semakin kompetitif sehingga kualitas produk yang dihasilkan haruslah sesuai dengan permintaan dan harapan pelanggan. Namun kecacatan produk dapat diminimalisir jika akar permasalahannya dapat diperbaiki sehingga kualitas produk dapat dikendalikan. Pada penelitian ini akan membahas terkait pengendalian kualitas pada produk bahan baku menggunakan metode DMAIC. Hasil penelitian menunjukkan bahwa penyebab terjadinya kecacatan produk yaitu karyawan yang kurang disiplin , perencanaan pada tindakan maintenance belum dilakukan serta tidak ada tempat untuk penyimpanan bleaching earth yang merupakan komponen penunjang proses produksi.
Economic Order Quantity (EOQ) Method Analysis, ABC Classification and Vital, Essential and Non Essential (VEN) Analysis of Medicines
Authors: Inayah Inayah , Alexandri Benny , Pragiwani Meita
Published: August 2024

This study aims to analyze the economic order quantity (EOQ) method, ABC classification as well as vital, essential and non-essential (VEN) analysis of drug supplies, to determine trends in the supply of vital (V), essential (E) and non-essential (N), to determine the frequency of purchasing drug preparations and the optimal amount of drug needs and to determine the total cost of supplies at the Dharma Pharmacy Clinic, Tangerang.
This study used a quantitative descriptive method and interviews were analyzed using QM software for Windows V.
From the research and calculations, the results obtained, in the analysis of vital (V), essential (E) and non- essential (N) classifications of 160 drug units classified as 66 units of vital drug classes, 58 units of essential drugs and 36 units of non-essential groups. In the use of the ABC classification analysis based on the investment value, it can be seen that group A from the vital drug group is 69.83% with a volume of 17 units, the essential drug group is 70.23% with a volume of 13 units and the non-essential group is 70.69% with a volume of 6 units. Group B of the vital drug group was 20.16% by volume 18 units, the essential drug group was 19.24% with a volume of 14 units and the non-essential group was 17.88% with a volume of 7 units. Group C vital group 10.01% volume 31 units, essential 10.53% by volume 31 units and 9.48% non essential group with volume 23 units. With the EOQ method in the procurement of drug preparations, the cost of purchasing a drug unit for a class of vital drugs is Rp. 1,069,223,104 with the lowest EOQ value of 1 and the highest is 105, for the essential drug class of Rp. 280,472,456, the lowest EOQ value is 1 and the highest is 41, and the non- essential drug class is Rp. 148,042,836 with the lowest EOQ value of 1 and the highest of 58.
Analysis of The Health of Financing Companies
Authors: Panjaitan Carolina , Suriawinata Iman Sofian , Anhar Muhammad
Published: August 2024

This study aims to determine and analyze the soundness of the case study financing company PT Astra Sedaya Finance (ASF) for the period 2020-2021 in terms of governance ratios, risk profiles, profitability and capital. The non-bank financial institution that is the main focus of this research is the financing company PT Astra Sedaya Finance (ASF). This research uses descriptive analytic method. The data used uses the financial statements of PT Astra Sedaya Finance (ASF) for 2020-2021. The results of this study indicate that PT Astra Sedaya Finance (ASF) during 2020-2021 in terms of governance factors, the results of self-assessment research get a value of 1, in accordance with applicable regulations to support the implementation of good corporate governance principles in every line of work. and operations of the Company. The results of the second factor research are the risk profile has inherent risk which is dominated by credit risk, has a strong risk management application, from the active supervision of the Board of Directors, Board of Commissioners, and DPS, as well as the completeness of policies and units in identifying, controlling, and monitoring management. risk in all functions, including the existence of three lines of defense in risk management. Thus, the risk profile of PT Astra Sedaya Finance is considered quite good. The results of the research on the third factor are profitability as long as, in terms of performance, it is very good, the ability of profits to increase capital and the prospect of future profits is still high with a value of 1 or very good. And the fourth factor, namely capital, as well as the profitability factor, has been very good. Different from banks which have minimum capital requirements regulated by OJK Regulation Number 11/POJK.03/2016 concerning Minimum Capital Adequacy Requirements for Commercial Banks, which is 8% of Risk Weighted Assets, with a capital ratio of 41.52% much higher than minimum requirement of 10%.
Penerapan ESG terintegrasi: Studi kasus PT Bukit Asam Tbk. dalam meraih proper emas tahun 2022
Authors: Wibowo Yohannes , Meiden Carmel
Published: August 2024

This research is a qualitative perspective to understand how the issuer applies Environment, Social, and Governance (ESG). The object of this research is Bukit Asam Tbk. The design of this research is a case study, with research variables assessing materiality, carbon disclosure quality, and corporate governance. The data used is the sustainability report for the period 2018-2022 and other secondary data. Sampling is done purposive sampling. Data analysis techniques using content analysis. My stakeholders define materiality as a priority topic, with the biggest stakeholder being customers, shareholders, officials, governments and policymakers; working partners, and suppliers; and the mass media. The environmental aspect is a major material issue. Highest carbon disclosure quality by 2022. The GRK category and the RC1 sub-sector are the highest disclosure quality. The corporate governance has produced an outstanding program in empowering local communities with a SROI ratio of 5.91, winning the Golden PROPER award. It can be concluded that the materiality assessment is good, the quality of disclosure is good and still needs to be improved, corporate governance is good. To the issuer, in order to maintain and improve implementation on ESG.
Case Studies and Best Practices in Cloud-Based Big Data Analytics for Process Control
Authors: Rishabh Rajesh Shanbhag  , Rajkumar Balasubramanian  , Ugandhar Dasi  , Nikhil Singla  , Siddhant Benadikar
Published: August 2024

In this research paper, case studies and exemplars and lessons learnt in cloud-based big data analytics for process control are reviewed. The paper presents big data, cloud computing and industrial process control system with prospects of enhancing effectiveness, increasing production rates, and effective decision making in the industries. The research in this paper involves a comprehensive literature review of the research topic, and an extension of the analysis to four specific business industries as well as a discussion of architectural elements for cloud-based big data solutions for process control business. It also presents various crucial issues such as data protection, adherence to legal requirements, and compatibility with other systems, giving solutions. In addition, the research compares the effectiveness of cloud-based solutions with on-premise ones and discuss other novelties, including edge computing and artificial intelligence as the tendencies potentially influencing process control. Consequently, the findings of this research can be helpful for both industry practitioners and researchers who aim to optimize process control and organization operation with the help of cloud-based big data analytics
TRIAGEM AVANÇADA EM SERVIÇOS DE URGÊNCIA E EMERGÊNCIA: IMPLEMENTAÇÃO DE PROTOCOLOS - UMA REVISÃO INTEGRATIVA
Authors: Isabelle Teixeira Zambrzycki  , Isabella Peixoto dos Santos  , Gleison Lucas Santos do Nascimento  , Welleson Feitosa Gazel  , Michel Simões dos Santos  , Emmanuel Oliveira Santos  , Taísi Lemos Pereira  , André Gabriel Lorini  , Clara Barbosa Martins  , Daniela Vieira de Paula
Published: August 2024

O superlotamento em Unidades de Urgência e emergência é um desafio global que impacta a qualidade e a segurança do atendimento. A Triagem Avançada (TA) emerge como uma estratégia para otimizar o fluxo de pacientes, reduzir o tempo de permanência e melhorar a eficiência. Este estudo visa avaliar o impacto da implementação das medidas de triagem avançada nos serviços de urgência e emergência. Trata-se de uma revisão integrativa, foram analisados diversos estudos para sintetizar as evidências disponíveis. Os resultados indicam que os TA reduzem significativamente o tempo de permanência, especialmente em serviços com alta demanda e longos tempos de espera. Essa otimização do fluxo de atendimento permite que os pacientes sejam avaliados e tratados mais rapidamente, liberando recursos e melhorando a eficiência do serviço. No entanto, desafios como treinamento adequado e resistência à mudança precisam ser superados. Estudos futuros com maior rigor metodológico são necessários para fortalecer as evidências e avaliar o impacto econômico da implementação da TA. Em suma, os TA mostram-se promissores para otimizar o atendimento em SE, desde que implementados com planejamento e acompanhamento adequados.
EDUCAÇÃO EM SAÚDE SOBRE ARBOVIROSES PARA UMA POPULAÇÃO RIBEIRINHA NA AMAZÔNIA: PERSPECTIVA PARA EMPODERAMENTO
Authors: Rabelo Mestria Thais , Tamara Alves Carretta Lucca , Schroth Baptista Mariana , Alves Gratival Raposo Francine
Published: August 2024

Objetivo: Qualificar a eficácia de ações de educação em saúde acerca de arboviroses, realizadas in loco e adaptadas ao contexto local, no empoderamento de populações ribeirinhas. Métodos: Estudo prospectivo de abordagem qualitativa e descritiva, desenvolvido a partir de uma coleta de dados com pacientes atendidos pelo barco-ambulatório Laguna Negra. Foram realizados, em formato de roda de conversa, um pré-teste, uma exposição oral e um pós-teste, todos acerca de arboviroses. Resultados: O pré-teste evidenciou desinformação ribeirinha sobre arboviroses. No entanto, após exposição oral dinâmica, o pós-teste imediato constatou boa retenção de informações. Conclusão: Portanto, considera-se a Educação em Saúde fundamental na promoção de mudanças permanentes no âmbito da saúde, haja vista o potencial da promoção de conhecimento  em gerar empoderamento, por estímulo à autonomia ribeirinha. Dessa forma, faz-se necessário ações de Educação em Saúde mais frequentes, de modo a prevenir doenças e agravos.