bluuebunny/crossref_metadata_2025 huggingface dataset:
A novel pancreaticoduodenectomy reconstruction for a patient with Roux-en-Y hepaticojejunostomy after radical extended left hepatectomy for perihilar cholangiocarcinoma
Authors: Ohwada Susumu , Sasaki Kazunari , Nakano Yuhei , Kawate Susumu , Kashima Yasushige , Matsuyama Hideki , Iijima Misa , Noda Naohiro , Hoshino Masato , Maruyama Hideki , Okauchi Kenzo
Published: February 2023

Background:
Metachronous cholangiocarcinoma in the remnant distal bile duct (BD) has been reported after the resection of perihilar cholangiocarcinoma. A pancreatoduodenectomy (PD) after radically extended hepatectomy with Roux-en-Y hepaticojejunostomy has significant surgical complexity in in both extensive adhesiolysis and digestive tract reconstruction. Herein, we reported a novel method of digestive tract reconstruction using the Y limb of pre-existing Roux-en-Y hepaticojejunostomy for pancreaticoduodenostomy and, subsequently, the Roux jejunal limb for gastrojejunostomy.
Case presentation:
A 74-year-old male developed distal BD cholangiocarcinoma six months after extended left hepatectomy for perihilar cholangiocarcinoma and subsequent adjuvant chemotherapy. The patient underwent extensive adhesiolysis followed by PD. His digestive tract was reconstructed by a novel method of PD reconstruction: the Y limb of the pre-existing Roux-en-Y hepaticojejunostomy was used for pancreaticoduodenostomy, and the Roux jejunal limb was used for the gastrojejunostomy. The tumor pathology demonstrated histologically stage Ib biliary duct adenocarcinoma with fibromuscular invasion.There were no complications of a pancreaticodeodenostomy fistula.
Conclusions:
This novel method of PD reconstruction for patients with Roux-en-Y hepaticojejunostomy could take advantage of the previous surgically altered anatomy and avoid further adhesiolysis for obtaining the adequate length of a new jejunal loop for pancreaticojejunostomy and gastrojejunostomy. This can be an optional PD reconstruction for patients with Roux-en-Y hepaticojejunostomy in cases of early-stage bile duct cancer and/or less likely to have lymph node metastasis.
Male partners’ involvement and its associated factors in promoting skilled birth use of wives in Dire Dawa Administration, eastern Ethiopia
Authors: Mohammed Aminu , Hailu Mickiale , Tadesse Daniel , Bireda Asma , Manaye Yibekal
Published: February 2023

Background
Male partner involvement in promoting skilled delivery is a process of social and behavioral change that men must undergo in order to prevent obstetric complications during childbirth. But this lacks information, and therefore, it was intended to be investigated in the study area.
Methods
A community-based cross-sectional study was conducted in the Dire Dawa administration, Ethiopia, from July 1 to 30, 2022, among male partners chosen using a systematic sampling technique. Data were collected through face-to-face interviews using a structured questionnaire, entered and cleaned by Epi DATA (Version 3.1), and analyzed using SPSS (Version 22). A P-value of 0.25 at bivariate to select variables for multivariate and 0.05 at multivariate with 95% confidence intervals was considered statistically significant.
Results
A total of 610 male partners participated, and male partners’ involvement in promoting skilled birth attendance was 51.8% (95% CI: 47.5–55.4%). The predictors were urban residence (AOR = 2.55, 95%CI: 1.75–3.73), diploma and above level of education (AOR = 2.00, 95%CI: 1.10–3.74), the perceived importance of skilled birth attendance (AOR = 1.98, 95%CI: 1.30–3.00), an antenatal care visit (AOR = 1.79, 95%CI: 1.04–3.07), and skilled birth attendance (AOR = 6.20, 95%CI: 3.4–11.33) with accompanying experiences.
Conclusion
Male partners' involvement in promoting their partners’ skilled birth attendance is moderate compared to other studies in Ethiopia. Stakeholders are recommended to use combined efforts to strengthen men's involvement and create continuous awareness about skilled birth utilization.
Black phosphorus quantum dots conjugated with dual antibodies improve tumor infiltrating CD8 + T cell activation and cancer immunotherapy
Authors: Liu Zhaoyuan , Li Wenting , Xue Ping , Jiang Xiaofeng
Published: February 2023

Tumor-infiltrating lymphocyte(TIL) therapy, an immunotherapy that uses CD8+T as the main killer cells isolated from the patient's tumor tissue to treat the patient's tumor, has shown efficacy in solid tumors. In the tumor microenvironment, effector CD8+T cells enter a state of impaired function known as T cell exhaustion. Therefore, how to improve their activity and rapid expansion in vitro is the key problem to be solved in TIL therapy. Combination immunotherapy has recently emerged as a potent cancer treatment strategy. And nanomaterials have shown great application value in the field of immunotherapy. We achieved optimal activation and amplification of CD8+T cells by combining organic nanomaterial black phosphorus quantum dots(BPQDs) with immune checkpoint inhibitory molecules PD-1 and LAG3. CD8+T cells enhanced cytotoxic function through a series of biomarkers (TNF-a and IFN-γ secretion) and targeted cell-killing measurements in vitro. It was related to the increase of CD8+T cells, and the increased function was more than the number of cells increased, indicating that the function of CD8+T cells was also enhanced. This work demonstrates a novel strategy for using organic nanotechnology to improve effective expansion and efficacy of tumor-infiltrating lymphocytes.
Comparison of optimized machine learning approach to understanding of medial tibial stress syndrome in military male personnel
Authors: Sobhani Vahid , Asgari Alireza , Arabfard Masoud , Ebrahimpour Zeynab , Shakibaei Abolfazl
Published: February 2023

The authors have requested that this preprint be removed from Research Square.
Discovering the Evolution Structure of Literature
Authors: Wu Siyuan , U Leong Hou
Published: February 2023

A common task in research work is to survey research work in bioliographic databases. Scientists are finding the survey task notably difficult as the volume of the databases has been increased considerably over the past few decades. Making a good use of a survey paper can vastly lower the difficulty but there may be no such paper existed in some emerging research topics. In this work, we propose a novel Literature Evolution Discovery (LED) process that aims to provide an explainable evolution structure of literature. The explain- ability is based on co-citation analysis and latent relationship extraction, which are done by Steiner tree and context-consistent factor graph model, respectively. The experiments show the superiority of our context-consistent factor graph model, compared with the state-of-the-art baselines. Our case studies and visualization results demonstrate the effectiveness and interpretability of our proposed algorithms in practice.
Fine Grain Algorithm Parallelization on a Hybrid Control-flow and Dataflow Processor
Authors: Korolija Nenad , Furht Borko , Milutinović Veljko
Published: February 2023

The execution time of a high performance computing algorithm depends on multiple factors: the algorithm scalability, the chosen hardware, the communication speed between processing elements, etc. This work is based on a hybrid processor consisting of both the control-flow and dataflow hardware, where the control-flow hardware includes manycore architecture. The algorithm decomposition into portions suitable for different architectures is presented. The results are presented by decomposing the Lattice-Boltzmann method implemented for both control-flow and dataflow hardware. The total acceleration factor of the decomposed Lattice-Boltzmann method comparing to the execution time using the control-flow and the dataflow hardware is obtained by the analysis based on the speed of the communication between both hardware equal to the speed of shared cache memories. Results indicate the advantage of using the proposed hybrid architecture and the capability of accelerating considerably even the suitable for dataflow architectures. The analysis of the problem size needed to justify the utilization of control-flow hardware is also presented. The main benefit is in accelerating algorithms for which only some algorithm portions are suitable for the dataflow hardware.
Candidate oncogene placenta specific 8 affect cell growth and cell migration in non- small cell lung cancers
Authors: Zhou Mei-Lin , Ma Jin-Ni , Xu Xin , Gao Xin-Yao , Wang Hai-Xia , Shen Jinhua , Xue Lu
Published: February 2023

Background
As a candidate oncogene, PLAC8 participate in genesis and progression of various tumors. However, the role of PLAC8 in lung cancer (LC) especially non-small cell lung cancer (NSCLC) is still limited.
Methods
We performed Tissue microarray analysis (TMA) and Real-Time PCR (RT-PCR) to detect the expression levels of PLAC8 in LC tissues and cell lines, respectively. Then a series of cellular experiments focusing on cell proliferation, cell cycle, cell motility were conducted to identified the role of PLAC8 in NSCLC-derived cell lines H1299 and A549.
Results
TMA and RT-PCR showed that PLAC8 played complicated even opposite roles in different LCs. Further cellular experiments confirmed that PLAC8 could promote cell viability, alter cell cycle, and accelerate cell mobility via regulation of cell cyclins or cadherins, respectively.
Conclusions
Our study indicated that PLAC8 might participate in LC especially NSCLC progression. Our study also shed new light on the potential role of PLAC8 as a therapeutic biomarker in NSCLC.
Outcomes of preoperative chemoradiotherapy after complete smoking cessation followed by total mesorectal excision with selective lateral pelvic lymph node dissection for locally advanced low rectal cancer
Authors: Inoue Akira , Kagawa Yoshinori , Nishizawa Yujiro , Komori Takamichi , Shimamoto Shigetoshi , Komatsu Hisateru , Miyazaki Yasuhiro , Tomokuni Akira , Motoori Masaaki , Fujitani Kazumasa
Published: February 2023

Purpose: Outcomes of patients with rectal cancer who underwent preoperative chemoradiotherapy after complete smoking cessation are unknown. We evaluated the outcomes of patients with locally advanced low rectal cancer who underwent combined preoperative chemoradiotherapy after complete smoking cessation and total mesorectal excision with selective lateral lymph node dissection. Predictive factors associated with response to preoperative chemoradiotherapy were investigated.
Methods: In this retrospective study at a tertiary medical center, 160 patients with locally advanced low rectal cancer who underwent surgical resection during January 2014–December 2019 were enrolled; data of 28 with stage II or III rectal cancer who underwent preoperative chemoradiotherapy and surgery were analyzed. Before chemoradiotherapy, a Smokerlyzer was used to measure expiratory carbon monoxide and monitor smoking cessation. Pathologic response rate and oncological outcomes were analyzed.
Results: No major post-surgical complications occurred. Pathologic complete response was achieved in 8/28 patients (28.6%). Three-year recurrence-free and overall survival rates were 81.4% and 92.4%, respectively. No patient developed local recurrence in lateral pelvic lymph nodes. Survival did not differ significantly between patients with and without pathologic complete response. In univariate and multivariate analyses, pretreatment hemoglobin (>13.0) [hazard ratio: 7.00 (95% confidence interval, 1.090–45.20); p=0.0408] and clinically negative N stage before treatment [hazard ratio: 18.9 (95% confidence interval, 1.63–218.0); p=0.0187] were significantly associated with pathologic complete response.
Conclusion: Preoperative chemoradiotherapy with complete smoking cessation followed by total mesorectal excision with selective lateral lymph node dissection was safely performed and resulted in high pathologic complete response rates and favorable survival outcomes.
Patient Satisfaction study in Outpatient setting in Tertiary Academic Hospital Patient Satisfaction in Outpatient Clinics
Authors: Abaalkhayl Mohammed , Abukraym Nader , Al-Najjar HANIHani
Published: February 2023

Purpose: To analyze and assess of satisfaction to the quality and performance of services provided in the outpatients Clinics of Tertiary Academic Care Hospital, and explore what is the factors affecting on it.
Methods: In a cross-sectional study at university hospitals in the Qassim region of Saudi Arabia, 476 outpatient online surveys were completed. The main content of the study was the basic characteristics of the patients. Statistical description, to identify influencing factors, chi-square analysis was utilized.
Results: The survey found that total outpatient satisfaction was 76.69±25.17, and the higher satisfaction factor scores were hospital facilities, Attitude and corporation of pharmacy staffs, language and communication of the physician, and registration process. The factors with lower scores were ease of finding OPD clinic, ease to find outpatients location, availability of prescribed medication.
Conclusion: For the continuation of the outpatient service process, patients with various educational levels, marital status, and first-time hospital visitors may receive special attention when receiving outpatient care.
The correlation between proline/P5C cycle and the response to avirulent pathogen infection in Arabidopsis
Authors: Zhang Yueqin , Ying Wenhan , Yang Rongchao , Cai Yuanyuan , Hua Xuejun
Published: February 2023

Proline/P5C cycle between mitochondria and cytosol, play important roles in energy supply and ROS generation in mammalian cell. Recently, in plant, proline-dependent ROS via proline/P5C cycle was proposed to be involved in hypersensitive reaction during plant response to avirulent pathogens. However, much remains to be elucidated about the regulation of proline/P5C cycle upon pathogen infection. Here, we reported the isolation and characterization of an Arabidopsis mutant proline resistance 2 (pre2), with a single dominant mutation in a single gene. Our results showed that the proline resistance phenotype of pre2 is not due to decreased intracellular proline content, when treated with exogenous proline. Upon proline treatment, pre2 showed reduced induction of PDH transcript level and enhanced induction of that of P5CDH, accompanied by lower level of mitochondrial ROS, suggesting an attenuated proline/P5C cycle activity. Proline-induced SA signaling was also less activated in pre2, as evidenced reduced free SA content and PR1 transcript level, compared to the WT. On the other hand, SA activation on the proline/P5C activity is to a lesser extent in pre2 than in WT. Significantly, pre2 demonstrated increased susceptibility to infection by avirulent pathogen Pst. DC3000 (avrRps4), accompanied also by lesser induced proline/P5C cycle activity by the pathogen. Our results indicated that there is a correlation between proline/P5C cycle and plant response to avirulent pathogen.
Assessing the risk of hypoglycemia secondary to propranolol therapy for the treatment of supraventricular tachycardia in infants
Authors: Parker Noah , Flowers Rhiannon , Vickery Kristen , Stolfi Adrienne , Bugnitz Christopher
Published: February 2023

Objective
Supraventricular tachycardia (SVT) is the most common arrythmia among infants. Prevention of SVT is frequently managed through propranolol therapy. Hypoglycemia is a known adverse effect of propranolol therapy, but little research has been done on the incidence and risk of hypoglycemia in treatment of SVT in infants with propranolol. This study attempts to offer insight into the risk of hypoglycemia associated with propranolol therapy when treating infantile SVT to help inform future glucose screening guidelines.
Methods
We conducted a retrospective chart review of infants treated with propranolol in our hospital system. Inclusion criteria were infants < 1 year of age who received propranolol for the treatment of SVT. A total of 63 patients were identified. Data was collected on sex, age, race, diagnosis, gestational age, nutrition source (Total Parenteral Nutrition (TPN) vs oral), weight (kg), weight for length (kg/cm), propranolol dose (mg/kg/day), comorbidities, and whether or not a hypoglycemic event was identified (< 60 mg/dL).
Results
Hypoglycemic events were identified in 9/63 (14.3%) patients. Of the patients with hypoglycemic events, 8/9 (88.9%) had comorbid conditions. Patients with hypoglycemic events had significantly lower weight and propranolol dose than those without hypoglycemic events. Weight for length also tended to increase risk for hypoglycemic events.
Conclusions
The high incidence of comorbid conditions in the patients who had hypoglycemic events suggests that hypoglycemic monitoring may only be necessary in patients with conditions predisposing to hypoglycemia.
Improving the accuracy of Covid-19 disease diagnosis with an improved fuzzy chaotic forest algorithm, optimal feature selection and decision tree
Authors: Motedayen Tahere , Yaghoobi Mahdi , Kheirabadi Maryam
Published: February 2023

Covid-19 is a new viral disease that spread in 2019 and turned into a pandemic over time. Due to its unknown nature, this disease caused a lot of human and financial losses in the current world. Several approaches were proposed to diagnose and apply medical care; One of the approaches that were more welcomed according to the results was the methods based on artificial intelligence. In the methods of artificial intelligence, various methods such as image processing, machine learning, etc. are used. Considering that in pandemic diseases, the number of patients is high and medical imaging is not without complications; Therefore, the use of clinical data and data mining techniques can be a suitable method in this field. But it should be kept in mind that in using data mining approaches, the lack of proper selection of features can hurt the analysis. Feature selection can be defined as the process of identifying relevant features and removing irrelevant and repetitive features to observe a subset of features that describe the problem well and with minimal loss of efficiency, and its purpose is to optimally select a subset of features with minimal redundancy and the maximum resolution ability. Therefore, the data mining process should pay attention to feature selection. In this article, a new method based on feature selection was proposed to increase the precision of the diagnosis of covid-19 disease. In the proposed method, we have used the fuzzy-chaotic forest optimization algorithm to select features that are effective on the covid-19 disease. This article has used four data sets collected by researchers of other scientific articles to evaluate the proposed method of diagnosing the disease of covid-19. The results of the evaluation in the important indicators of machine learning (precision, accuracy, recall and F1) show that in Comparing with similar algorithms, the proposed method provides better results and by increasing the accuracy of diagnosis, it can better diagnose the disease of Covid-19 In such a way, it improves the precision of diagnosis by 2% and reduces the dimensions of the diagnosis problem by 46%.
m5C related-regulator-mediated methylation modification patterns and prognostic significance in breast cancer
Authors: Wu Xinpei , Li Chenquan , Luo Yinyi , Ren Xiya , Cheng Chen , Zhang Guangwen , Wang Zhe , Wang Shiming
Published: February 2023

Background: Breast cancer (BC) is the most common malignancy worldwide. 5-methylcytosine (m5C) is closely related to cancer and its mechanism in BC remains unclear. We aimed to assess the expression of m5C regulators involved in BC and investigate their correlation with the prognosis of BC.
Methods: BC samples from TCGA and GEO databases were respectively analyzed as the training and testing sets, and identified their m5C modification patterns based on the differential expression of m5C-related regulators and construct an m5C scoring system. Subsequently, we evaluate the value of m5C modification in predicting prognosis, investigate the underlying pathways and functions associated with m5C modification, identify m5C modifications related to the infiltration of immune cells in the tumor microenvironment and assess the patients' potential response to pharmacotherapy based on m5C patterns.
Results: Three distinct m5C modification patterns were identified in the training dataset. Based on the m5C-related differentially expressed genes, the m5Cscore was constructed, and divided BC patients into high and low m5Cscore groups. Patients with a high m5Cscore had more abundant immune cell infiltration and better prognosis. However, a low m5Cscore was linked to an enhanced response to immunotherapy. Finally, the potential roles of the m5Cscore were validated in the testing dataset, and the results demonstrated the stability of the m5Cscore and its independent prognostic value.
Conclusions: This study revealed the m5Cscore is a potential tool for evaluating m5C modification patterns and immune cell infiltration in individual patients and has the potential to be a novel prognostic marker for BC.
Abnormal development of circular muscles in aganglionic segments of HSCR patients
Authors: Chen Ke , You Jingyi , Yang Shimin , Meng Xinyao , Chen Xuyong , Wu Luyao , Yu Xiaosi , Xiao Jun , Feng Jiexiong
Published: February 2023

Background
Hirschsprung’s disease (HSCR) is one of the most common malformations of the digestive tract. Patients with HSCR frequently manifest as having severe constipation and abdominal distension. The primary pathological feature of HSCR is the absence of ganglion cells in the distal bowel, and the arrangement of the circular and longitudinal muscles of the aganglionic segments is disorganized. To function properly, it requires an intact muscular layer as well as a neural network connection. Previous research has suggested that HSCR is a neurological disorder; however, HSCR may also be a muscular cell disorder of the intestinal smooth muscle.
Methods
To investigate the development rules of circular and longitudinal muscles and to research whether ENCCs affect smooth muscle function. αSMA immunohistochemistry was used to stain tissues of HSCR patients and HSCR model mice at different developmental stages.
Results
Under normal circumstances, the formation of circular muscles is later than that of longitudinal muscles, and the expression of αSMA in circular muscles is much lower than that in longitudinal muscles. The expression of αSMA in anganglionic segments of HSCR patients is much higher than that in the distal colon of normal control children.
Conclusions
Loss of ENCCs may influence the function of the circular muscles, αSMA is a biomarker for detecting the abnormal smooth muscle cell in Hirschsprung's disease patients' aganglionic segments.
The Mathematics Teacher at the Crossroads Between Indigenous Cultural and Exotic Games in Teaching Mathematics
Authors: Ali Clement Ayarebilla , Tangkur Michael
Published: February 2023

The issue of integrating indigenous games in Africa had long been conceived by Mogege David Mosimege in the 1990s. Of late, several countries and universities have introduced indigenous games into their curricula at all levels of education. However, with serious competition with the exotic education games, the mathematics teacher is still at the crossroads of integrating these games. One of the most challenging aspects is determining the games that best suit particular topics. The purpose of this study was to explore teachers' challenges in some selected topics and suggest ways best practices of resolving the impasses. Deeply rooted in Piaget constructivism, the phenomenological design was harnessed to address the purpose, objectives and research questions carved to guide the study. With a population of over 200 teachers, the researchers sampled 70 teachers (65 males, 5 females) through simple random sampling for the first stage. Five teachers, comprising three males and two females, were purposively sampled for the second stage. The semi-structured interview guide and an observation checklist were the instruments the researchers used to collect data. The data was analyzed thematically to reflect the research questions. The results of both stages showed that even though a good number of teachers cannot decided on any games and substantial number were still being influenced by the other cultural games, some teachers who selected the indigenous games yielded impact on students’ learning of mathematics. The four indigenous games, namely biloo, bilore, gollaa and mullaa were dominant. However, the observation checklist showed that many teachers are at serious crossroads of selecting indigenous games for the teaching of mathematics. It was therefore recommended that stakeholders reinvent teaching and learning through the integration of games and culture.
Association of Functional Health Literacy (FHL) with Socio-demographic Status and Physical Activity of Type 2 Diabetic Patients in Bangladesh: A Cross-sectional Study
Authors: Islam Md. Monirul , Hossain Syed Billal , Muhammad Faisal , Chowdhury ABM Alauddin , Khan Salim
Published: February 2023

Background
This study aimed to determine the level of functional health literacy (FHL) among type 2 diabetes patients and its relationship to their socio-demographic status and physical activity.
Methods
A cross-sectional study was undertaken. A semi-structured questionnaire including a short test of FHL was used to collect data from adult Type 2 Diabetic patients (n = 401) attending a diabetic center in Bangladesh. All participants were provided with a study information sheet and consent form. The study objective was the focus of the analysis, and so were the indicators. Data were analyzed using Fisher's exact χ2 test, bivariate and multivariate linear regression with a 95% Confidence Interval (CI) to evaluate the association among variables.
Results
Around 60% of participants were female, with the majority having completed elementary or secondary school. Both of these factors are shown to be very significant (P < 0.001) with level of FHL. The FHL level of the participants was revealed to be associated with walking as a means of regular physical exercise. More than one third of the respondents (33%) did not undertake regular physical exercise, whilst the remainder (68%) walked every day. A small proportion (11%) walked to work each day, and this had a strong correlation with their level of FHL (P < 0.001). Social Media interaction had a significant association with level of FDH (P < 0.001).
Conclusion
Increased functional health literacy among type 2 diabetes patients can significantly assist them to live a healthier lifestyle.
High coincidence rate of fluid identification of carbonate reservoirs in Yan'an gas field by gas logging bright spot -resistivity dark spot technology
Authors: Hu Dengping , Wang Rungang , Zhou Jintang , Wang Yan
Published: February 2023

The main gas layer of the Lower Paleozoic in the Yan'an gas field in the Ordos Basin is the carbonate rock of the Majiagou Formation, which is a low-porosity and low-permeability reservoir. Its storage space is mainly composed of intercrystalline pores, intercrystalline dissolved pores, dissolved caves and micro-fractures, with strong heterogeneity. The reservoir generally contains pyrite, which makes the resistivity value negatively abnormal, which interferes with the identification of low-resistivity fluids in the high-resistivity background. This leads to the failure of traditional logging interpretation methods and the low coincidence rate of reservoir interpretation. Through the statistical analysis of 240 drilling and gas testing data, the sensitive parameters of logging total hydrocarbon and logging resistivity are selected from many reservoir parameters. On this basis, after effective technical treatment, a “gas logging bright spot-resistivity dark spot technology” for carbonate reservoirs is formed. Through the field application and gas test results of 35 wells in Yan'an gas field in 2021, the interpretation coincidence rate is as high as 83%, which is much higher than the previous traditional method coincidence rate (44.3%). This study organically combines the advantages of mud logging and logging technologies, and establishes a reservoir interpretation chart and standard, which solves the long-standing problem of low coincidence rate in the identification of carbonate reservoir fluids in the geological community. An effective method for predicting favorable carbonate oil and gas areas is provided.
Therapeutic management of uterine tumors resembling ovarian sex cord tumors: Systematic Review
Authors: Shibahara Mami , Kurita Tomoko , Harada Hiroshi , Tsuda Yojiro , Hisaoka Masanori , Yoshino Kiyoshi
Published: February 2023

Objective:
Uterine tumors resembling ovarian sex cord tumors (UTROSCTs) are extremely rare, and most cases have a benign clinical course. We report the first review of treatment and prognosis, including a focus on fertility.
Methods:
We conducted a systematic review of UTROSCT case reports and case series in English till June 2022 and compared initial treatment and recurrence rates. The following was extracted: age; symptom; initial therapy; metastasis at diagnosis; recurrence.
Results:
In total, 122 cases (61 articles) reporting the clinical course of UTROSCTs were analyzed. The median age at diagnosis was 50.0 years, and 26 (21.3%) patients were aged < 40 years. Most patients (n=103) underwent hysterectomy as the initial surgery, with a recurrence rate of 19.4% (n=20). Recurrence occurred in 29.4% (n = 5) of patients who underwent mass resection (n=17). Among the patients, 13 were under 40 years of age, seven had achieved pregnancy (53.8%), and six had successful deliveries (46.2%).
Conclusion:
While total hysterectomy is the recommended treatment for UTROSCTs based on recurrence rates, mass resection as fertility-preserving surgery is an acceptable treatment option for patients who desire childbearing.
Formulation of a Gel Containing Asiaticoside from Pegagan (Centella asiatica l.) and Curcumin Isolate from Turmeric (Curcuma longa l.) as a Nano Medicine Particle Delivery System
Authors: Agusti Arsyadi , Tuba Syahrul
Published: February 2023

Pegagan (Centella asiatica) and turmeric (Curcuma longa) have a chemical that has been identified and utilized for wound healing. The study looked into how to make a gel with asiaticoside extract from Pegagan and curcumin isolate from turmeric and a nanoparticle delivery system to heal wounds caused by exercise and surgery. The rhizomes of pegagan and turmeric were taken out to make a gel preparation with a nanoparticle delivery system. Also, the extract was standardized and turned into nanoparticles. Finally, the gel preparation formula was made. Asiaticoside and curcumin gel nanoparticles were made by adding chitosan to a 0.1% sodium tripolyphosphate solution. Furthermore, physical examination and gel stability testing were performed on the three gel formulations with varying concentrations of NaCMC, such as 5%, 3%, and 15%. Asiaticoside nanoparticles had a size of 83.87 nm, while curcumin nanoparticles had a size of 62 nm, according to the results of the nanoparticle characterization. The viscous test for gel formulations employs gel viscosity standards of 80.000 (F1) cp, 34.000 cp (F2), and 3.600 cp (F3). The gel is stable for 30 days due to its organoleptic value and viscosity. Based on the results of a physical exam, Formula 3 is the best way to make a gel preparation with asiaticoside and curcumin nanoparticles.
Assessment of Orthodontic Canine Retraction via Two Approaches of Periodontal Distraction:
A Comparative Clinical Study
Authors: El-Hendawey Alaa , Hussein Farouk , Hssan Susan , Mohamed Maha
Published: February 2023

Background
This study aimed to assess and compare two approaches of periodontal distraction during orthodontic canine retraction.
Methods
A consecutive sample of 27 patients (54 canines) requiring extraction of upper 4s and canine retraction were grouped into three groups; canine retraction by using buccal periodontal distractor with distal interseptal bone cuts (group I), canine retraction by using buccal periodontal distractor without distal interseptal bone cuts (group II), conventional canine retraction on miniscrew (group III). The patients were evaluated before (T0) and after canine retraction (T1) for rate of canine retraction directly in patient’s mouth and at 1st ,2nd ,4th and 7th days after activation for pain sensation through visual analog scale (VAS).
Results
Regarding the rate of canine retraction, statistical analysis revealed that there was a significant difference between 3 groups. A significantly higher value was recorded in group I, followed by group II, with the lowest value recorded in group III (P-value > 0.05). Regarding pain score, statistical analysis revealed that there was no statistically significant difference between group I and II (p < 0.05) but the values recorded in them was significantly higher than group III within 1st and 2nd days (p > 0.05) respectively. Within 4th and 7th days, there was statically significant difference between 3 groups with the highest pain value in group II, followed by group I, with the lowest value in group III (p > 0.05).
Conclusions
canine retraction movement was accelerated effectively by periodontal distraction technique either with or without distal interseptal bone cuts; the periodontal distraction with distal interseptal bone cuts was higher in rate of canine retraction and lower in pain sensation than the periodontal distraction without distal interseptal bone cuts.
Trade in Services and Income Inequality in Africa: The Role of Information and Communication Technologies
Authors: Wonyra Kwami Ossadzifo , Tenakoua Honoré , Cassama Braima Luís Soares
Published: February 2023

With the advent of the technological revolution, trade in services is of paramount importance in major international trade issues. This paper analyses the effects of trade in services in general and ICTs in particular on income inequality in 46 African countries over a decade 2009–2018. It focuses in particular on the channels through which trade in services affects income inequality. The results from the estimates show a robust and significant inverse relationship between trade in services and income inequality in Africa. Greater participation in international trade in services reduces inequalities in intra-national income distribution in Africa. The results suggest that the interaction of trade in services and internet penetration has a positive impact on income inequality in Africa.
JEL Classification: F10, D31, C23
The Effect of Digital Marketing Strategy on Customer and Organizational Outcomes
Authors: YachouAityassine Fatima Lahcen , Al-Ajlouni Mahmoud Mohammad , Mohammad Anber
Published: February 2023

This study aims to test the impact of digital marketing strategy as an antecedent on customer outcomes (customer satisfaction, customer engagement, and customer loyalty) and the impact of these three outcomes on organizational outcomes. Twenty-five items are used to measure research variables. These items are developed referring to previous related works: digital marketing strategy, customer satisfaction, customer engagement, customer loyalty, and organizational outcomes. According to the research budget and time constraints, a convenience sampling method was implemented in the data collection process. This study applied structural equation modeling (SEM) to test the research hypotheses through AMOS software.The authors conducted a questionnaire to collect data from a sample of marketing practitioners selected from 10 organizations with a total number of 200 respondents. The total number of returned questionnaires is 187 responses. Eleven questionnaires are excluded due to invalid responses. Thus, 176 questionnaires are used to carry out data analysis. The results underline the significant effects of customer satisfaction, engagement, and loyalty on organizational outcomes. The authors noted that customer satisfaction is the most affected outcome by digital marketing strategy, followed by customer engagement and customer loyalty. Additionally, customer loyalty has the greatest effect on organizational outcomes, followed by customer satisfaction and customer loyalty. The findings showed that enhancing organizational outcomes requires marketing managers consider customer outcomes such as customer satisfaction, customer engagement, and customer loyalty, which are affected by marketing strategies. Marketing managers are requested to pay great attention to their marketing strategy, considering its effects on customer satisfaction and other customer outcomes, like customer engagement and loyalty. Likewise, scholars are required to re-test the current model to identify the mediating role of the outcomes mentioned above in the effect of marketing strategy on organizational outcomes.
Marketing 5.0: An Empirical Investigation of Its Perceived Effect on Marketing Performance
Authors: Alanazi Tawfeeq Mohammed
Published: February 2023

The study aims to explore the effect of marketing 5.0 on marketing performance. Marketing 5.0 was conceptualized using three dimensions: predictive marketing, contextual marketing, and augmented reality marketing. This study uses a questionnaire to collect data from a sample of employees working in marketing departments in 25 furniture stores. Eight employees were selected based on their managers’ recommendations regarding employee knowledge of digital marketing. The total number of the sample is 200 participants. Data were collected using a questionnaire designed as a five-point Likert scale. A total of 190 questionnaires were returned valid for data analysis. The results revealed that both contextual and augmented marketing significantly affect marketing performance. In contrast, predictive marketing exerts no significant effect on marketing performance. The above results concluded that enhancing marketing performance requires advanced human-oriented technologies. These technologies transform customers from traditional marketing environments into real-world environments by collecting and analyzing real-time customer data during the shopping process at sale points to affect customer behavioral intention and purchasing decisions. Theoretically, this study enriches the literature on marketing 5.0 by investigating the effects of three related kinds of marketing (predictive marketing, contextual marketing, and augmented marketing) on marketing performance. It provides researchers with a theory based upon which they could develop new models to examine the effects of marketing 5.0 on marketing outcomes. Empirically, the study shows that augmented marketing in the marketing 5.0 era is the most significant. It could be used to enhance the customer shopping ex
Building models of topological quantum criticality from pivot Hamiltonians
Authors: Tantivasadakarn Nathanan , Thorngren Ryan , Vishwanath Ashvin , Verresen Ruben
Published: February 2023

Progress in understanding symmetry-protected topological (SPT) phases
has been greatly aided by our ability to construct lattice models
realizing these states. In contrast, a systematic approach to
constructing models that realize quantum critical points between SPT
phases is lacking, particularly in dimension
d>1d>1.
Here, we show how the recently introduced notion of the pivot
Hamiltonian—generating rotations between SPT phases—facilitates such a
construction. We demonstrate this approach by constructing a spin model
on the triangular lattice, which is midway between a trivial and SPT
phase. The pivot Hamiltonian generates a U(1)U(1)
pivot symmetry which helps to stabilize a direct SPT transition. The
sign-problem free nature of the model—with an additional Ising
interaction preserving the pivot symmetry—allows us to obtain the phase
diagram using quantum Monte Carlo simulations. We find evidence for a
direct transition between trivial and SPT phases that is consistent with
a deconfined quantum critical point with emergent
SO(5)SO(5)
symmetry. The known anomaly of the latter is made possible by the
non-local nature of the U(1)U(1)
pivot symmetry. Interestingly, the pivot Hamiltonian generating this
symmetry is nothing other than the staggered Baxter-Wu three-spin
interaction. This work illustrates the importance of
U(1)U(1)
pivot symmetries and proposes how to generally construct
sign-problem-free lattice models of SPT transitions with such anomalous
symmetry groups for other lattices and dimensions.
Electrochemical detection of nickel(II) and zinc(II) ions by a dicarboxyl-Calix[4]arene-based sensor (Calix/MPA/Au) through differential pulse voltammetry analysis
Authors: Aziz Siti Fatimah Nur Abdul , Ainliah Alang Ahmad Shahrul
Published: February 2023

Herein, we report a facile approach for constructing a calixarene-based electrochemical heavy metal sensor (Calix/MPA/Au) via a one-pot reaction for the detection of Ni(II) and Zn(II) ions. The surface elemental properties and analytical performance of the Calix/MPA/Au sensor were characterized by X-ray photoelectron spectroscopy (XPS) and differential pulse voltammetry (DPV). Under optimum conditions, the sensor exhibited detection limits of 1.5 and 0.34 mg/L at linear ranges of 2.85–6.65 and 0.13–1.68 mg/L for the Zn(II) and Ni(II) ions, respectively. The developed sensor exhibited a better electrochemical performance in the detection of Zn(II) and Ni(II) ions owing to the favourable host–guest interactions between the hydroxyl groups-functionalized lower rim of dicarboxyl-calix[4]arene and the metal ions. The RSD of the five independent Calix/MPA/Au electrode for Zn(II) and Ni(II) ions was calculated to be 16.3 and 16.1%, respectively. Despite the lower sensitivity of the modified electrode towards Ni(II) ions, this finding proves the high selectivity of the calixarene as a detection probe towards the fitted size of guest ion, hence promising to be assembled and explored as a solid-state based-supramolecular host molecule for tracing metal ions.
Influence of power generation period on the oily sludge bio-electrical system
Authors: Zeyu Zhong , Guo Haiying , Huang Chunfeng , Geng Xiaoheng , Jia Xinlei , Huo Hongjun , Li Fanru , Jianfei Gao
Published: February 2023

The single-chamber bio-electrical systems can degrade oily sludge in sediments while generating electricity from the microbial fuel cells (MFCs) and their characteristics in energy and environmental effects have attracted wide international attention in recent years. To explore the influence of the power generation period on the oily sludge bio-electrical system, an oily sludge bio-electrical system was constructed. The output voltage, polarization curve, power density curve, crude oil removal rate and microflora were detected during different power generation periods, respectively. The results of this study showed that under the stable power generation period, the power generation and oily sludge degradation performance of MFC are higher than the voltage rise period and voltage attenuation period. Besides, the oily sludge bio-electrical system during the stable period contained more electricity-producing bacteria than the other two periods. The voltage in the stable period of oily sludge bio-electrical system is about 280 mV, the electromotive force is 493.1 mV and the power density is 134.93 mW·m−3. It lays a foundation for the improvement of degradation of crude oil and power generation performance in oily sludge bio-electrical system.
Whole campus wastewater surveillance of SARS-CoV-2 for COVID-19 outbreak management
Authors: Sharaby Y. , Gilboa Y. , Alfiya Y. , Sabach S. , Cheruti U. , Friedler Eran
Published: February 2023

In this long-term study (eight months), a wastewater-based epidemiology program was initiated as a decision support tool for the detection and containment of COVID-19 spread in the Technion campus. The on-campus students' accommodations (∼3,300 residents) were divided into housing clusters and monitored through wastewater SARS-CoV-2 surveillance in 10 manholes. Results were used to create a ‘traffic-light’ scheme allowing the Technion's COVID-19 task force to track COVID-19 spatiotemporal spread on the campus, and consequently, contain it before high morbidity levels develop. Of the 523 sewage samples analysed, 87.4% were negative for SARS-CoV-2 while 11.5% were positive, corroborating morbidity information the COVID-19 task force had. For 7.6% of the SARS-CoV-2 positive samples, the task force had no information about positive resident/s. In these events, new cases were identified after the relevant residents were clinically surge tested for COVID-19. Hence, in these instances, wastewater surveillance provided early warning helping to secure the health of the campus residents by minimising COVID-19 spread. The inflammation biomarker ferritin levels in SARS-CoV-2 positive sewage samples were significantly higher than in negative ones. This may indicate that in the future, ferritin (and other biomarkers) concentrations in wastewater could serve as indicators of infectious and inflammatory disease outbreaks.
A Perspective on Bone Morphogenetic Proteins: Dilemma behind Cancer-
related Responses
Authors: Kapoor Anmol , Mandal Chandi C.
Published: February 2023

Bone morphogenetic proteins are a center of serious concern and are known to execute
various cancer-related issues. The BMP signaling cascades have become more unpredictable as a
result of their pleiotropic and risky characteristics, particularly when it comes to cancer responses.
This perspective discusses the current therapeutic implications, emphasizes different cellular aspects
that impact the failures of the current drug treatments, and speculates on future research avenues
that include novel strategies like metabolomic studies and bio-mimetic peptide therapeutics
to mitigate cancerous outcomes.
Effects of Different Etiologies of Anterior Circulation Tandem Lesions on
Short-term Prognosis of Acute Ischemic Stroke
Authors: Xiao Guodong , Liu Chun-Feng , Huang Zhichao , Xu Yingying , You Shoujiang , Guo Zhiliang , Xu Jiaping , Cao Yongjun
Published: February 2023

Introduction:

The prognosis of anterior circulation tandem lesions caused by carotid artery
dissection (CAD) and large artery atherosclerosis (LAA) after mechanical thrombectomy is controversial.
By analyzing the clinical data of different etiologies, we explored the best treatment plan.

Methods:

Clinical data of patients with anterior circulation tandem lesions admitted to the Second
Affiliated Hospital of Soochow University from April 2018 to October 2021 were retrospectively
collected. The Modified Rankin Scale was used as the standard to evaluate the functional prognosis
of patients at 3 months. Safety assessment included symptomatic intracranial hemorrhage (sICH)
and mortality. The technical evaluation of interventional procedures included operation time, successful
recanalization, and times of pass.

Results:

74 patients were enrolled, 59 in the LAA group and 15 in the CAD group. The two groups
were similar regarding the proportion of successful recanalization, the bridge treatment and the
choice of surgical instruments. The puncture to recanalization time and the onset of symptoms to
successful recanalization time had no significant difference (p > 0.05). There were no significant
differences in hemorrhage transformation (p = 0.26), sICH (p > 0.999), good functional prognosis
(p = 0.054), and mortality (p = 0.181) between the two groups. We found a trend toward a better
functional outcome at 3 months in the CAD group (p = 0.054).

Conclusion:

The tandem lesions of anterior circulation caused by CAD tend to have a good functional
prognosis in 3 months. The proportion of successful recanalization and surgical safety was
similar between the two groups.