bluuebunny/crossref_metadata_2025 huggingface dataset:
Noninvasive high-resolution deep-brain photoacoustic imaging with a negatively focused fiber-laser ultrasound transducer
Authors: Xu Hexiang , Chen Zitao , Wu Yuhan , Hou Chengtian , Ma Jun , Guan Bai-Ou
Published: October 2024

Noninvasive high-resolution deep-brain imaging is essential to fundamental cognitive process study and neuroprotective drugs development. Although optical microscopes can resolve fine biological structures with good contrast without exposure to ionizing radiation or a strong magnetic field, the optical scattering limits the penetration depth and hinders its capability for deep-brain imaging. Here, in vivo high-resolution imaging of the whole mouse brain is demonstrated by using a photoacoustic computed tomography system with a negatively focused fiber-laser ultrasound transducer. By leveraging the high flexibility and low bending loss of the optical fiber, a rationally designed negatively focused fiber laser cavity exhibits a low detection limit down to 5.4 Pa and a broad view angle of ∼120  deg, enabling mouse brain imaging with a penetration larger than 7 mm and a nearly isotropic spatial resolution of ∼130  μm. In addition, the negative curvature of the fiber laser reduces the working distance, which facilitates the development of a compact and portable linear scanning imaging system. In vivo imaging of a mouse model with intracerebral hemorrhage is also showcased to demonstrate its capability for potential biomedical and clinical applications. With high spatial resolution and large tissue penetration, the system may provide a noninvasive, user-friendly, and high-performance imaging solution for biomedical research and preclinical/clinical diagnosis.
Parity effects in Rydberg-state excitation in intense laser fields
Authors: Liu Yang , Yi Xiaopeng , Chen Qi , Sun Tian , Lv Hang , Hu Shilin , Becker Wilhelm , Xu Haifeng , Chen Jing
Published: October 2024

Conservation of parity plays a fundamental role in our understanding of various quantum processes. However, it is difficult to observe in atomic and molecular processes induced by a strong laser field due to their multiphoton character and the large number of states involved. Here we report an effect of parity in strong-field Rydberg-state excitation (RSE) by comparing the RSE probabilities of the N2 molecule and its companion atom Ar, which has a similar ionization potential but opposite parity of its ground state. Experimentally, we observe an oscillatory structure as a function of intensity with a period of about 50  TW/cm2 in the ratio between the RSE yields of the two species, which can be reproduced by simulations using the time-dependent Schrödinger equation (TDSE). We analyze a quantum-mechanical model, which allows for interference of electrons captured in different spatial regions of the Rydberg-state wave function. In the intensity-dependent RSE yield, it results in peaks with alternating heights with a spacing of 25  TW/cm2 and at the same intensity for both species. However, due to the opposite parities of their ground states, pronounced RSE peaks in Ar correspond to less pronounced peaks in N2 and vice versa, which leads to the period of 50  TW/cm2 in their ratio. Our work reveals a novel parity-related interference effect in the coherent-capture picture of the RSE process in intense laser fields.
Ultra-linear FMCW laser based on time-frequency self-injection locking
Authors: Zhang Jichen , Li Shangyuan , Zheng Xiaoping , Xue Xiaoxiao
Published: October 2024

Frequency-modulated continuous-wave (FMCW) light sources are essential components for coherent light detection and ranging (LiDAR), which is ubiquitously utilized in autonomous driving, industrial monitoring, and geological remote sensing. Traditional FMCW LiDAR systems often face challenges in achieving high frequency-sweep linearity and large excursion, which are critical for accurate distance and velocity measurements. Here, we propose a self-injection locked laser with frequency-shifted feedback to generate ultra-linear and wideband FMCW light. A record-low relative frequency nonlinearity of 6.4×10−7 is achieved when the frequency excursion is 100 GHz and the repetition frequency is 1 kHz. In the LiDAR test, a range resolution of 1.6 mm and a velocity accuracy of 3 mm/s at 300 m distance are demonstrated, and those of 8.1 mm and 6 mm/s at 1 km distance are also obtained. The reported FMCW light source provides not only enhanced performance in coherent LiDAR, but also utilization potential in various high-precision measurement scenarios.
Energy use and greenhouse gas emissions in selected tea factories in Kenya
Authors: Kibet Joy J. , Letema Sammy
Published: October 2024

Tea sector is a major contributor to Kenya’s economy through foreign exchange via export. However, extensive amount of energy is required to produce one kilogram of tea, making tea processing energy-intensive. Comparing greenhouse gas emissions from different types of energy consumed in tea factories is imperative to enable policymakers make informed intervention in emission reduction. Reducing greenhouse gas emissions in tea factories is one of the pathways to meeting Kenya’s nationally determined 32% reduction of carbon emissions by 2030 and commitment to the Paris Agreement. This paper assesses greenhouse gas emissions from different sources of energy used in four tea factories in Kenya. The Intergovernmental Panel on Climate Change emission factor is used to calculate the total emissions of each type of energy used for 5 years. Life cycle assessment using SimaPro 8 software, Eco-indicator 99 method and Eco invent database was used to assess the specific compound causing the emission. The findings reveal that the 5-year greenhouse gas emissions by biogas, solar, wood, briquettes, and electricity are 336.111, 7.108, 3057.729, and 1,338.28 kg CO2/MWh, respectively. Firewood has the highest concentration of carbon dioxide, while solar energy has the least. Analysis of variance confirms significant difference (0.05>p = 0.0272) in greenhouse gas emissions from the different energy sources. Post-hoc analyses shows a significant difference in emissions between solar and firewood (p<0.0125) and no significant difference between other sources of energy. The key environmental hotspot is the energy intensive processes such as drying involved in tea production and processing, which leads to consumption of fossil fuel in the factories. To reduce such key hotspot, switching to renewable energy sources is key. Sustainability in the tea sector can therefore be achieved through switching to macadamia briquettes as a source of thermal energy and a combination of electricity and solar for electrical energy.
Evaluation of a cross-border field simulation exercise on the response to outbreaks of infectious diseases in Namanga, Kenya and Tanzania
Authors: Dzaba John Sackey , Njenge Hilary Kagume , Wakhungu James , Reintjes Ralf , Watt Nicola
Published: October 2024

Travel and trade, whilst playing a critical role in economic development, contribute to the spread of infectious diseases, including novel or emerging diseases, which can threaten health security locally, regionally and globally. The World Health Organization mandates preparedness through field simulation exercises to address infectious disease outbreaks, as highlighted by the COVID-19 pandemic. This study assessed the impact of the 2019 Namanga field simulation exercise, conducted in the border town shared by Kenya and Tanzania, on improving cross-border outbreak preparedness and response. It focused on participants’ knowledge, skills acquisition and real-world application. An anonymous online survey was administered to participants 37 months post-field simulation exercise. In addition, key informant interviews and a focus group discussion with the Joint Border Management Committee in Namanga were conducted. The June 2019 field simulation exercise enhanced the skills, knowledge, and confidence of participants, including members of the border community, in preparing for and responding to outbreaks including COVID-19. The skills and knowledge gained were deemed valuable, relevant, and effective for use in future response activities. The analysis is limited by potential response bias, as only participants with positive experiences of the field simulation exercise may have responded more favourably. Addressing the limitations of design and implementation of the field simulation exercise and the challenges of cross-border response identified in this study are critical to optimising future responses.
Institutional trust, conspiracy beliefs and Covid-19 vaccine uptake and hesitancy among adults in Ghana
Authors: Achore Meshack , Braimah Joseph Asumah , Dowou Robert Kokou , Kuuire Vincent , Ayanore Martin A. , Bisung Elijah
Published: October 2024

Vaccine hesitancy is considered one of the ten threats to global health. In the context of the COVID-19 pandemic, vaccine hesitancy may undermine efforts toward controlling or preventing the disease. Nevertheless, limited research has examined vaccine hesitance, particularly in low- and middle-income countries (LMICs). It is thus imperative to examine how institutional trust and conspiracy belief in tandem influence the uptake of COVID-19 vaccines. Using data (n = 2059) from a cross-sectional study in Ghana, this study examines the association between institutional trust, conspiracy beliefs, and vaccine uptake among adults in Ghana using logistics regression. The regression model (model 3) adjusted for variables such as marital status, age, gender, employment, income, and political affiliations. The results show that individuals were significantly less likely to be vaccinated if they did not trust institutions (OR = .421, CI = .232–.531). Similarly, we found that individuals who believed in conspiracy theories surrounding the COVID-19 vaccine were less likely to be vaccinated (OR = .734, CI = .436–.867). We also found that not having a COVID-19-related symptom is associated with vaccine refusal (OR = .069, CI = .008–.618). Similarly, compared to those with a vaccine history, those without a vaccine history are less likely to accept the COVID-19 vaccine (OR = .286, CI = .108–.756). In conclusion, our results demonstrate the need for enhanced education to tackle conspiracy beliefs about the disease and enhance vaccine uptake. Given the role of trust in effecting attitudinal change, building trust and credibility among the institutions responsible for vaccinations ought to be prioritized.
As good as it gets? A new approach to estimating possible prediction performance
Authors: Anderson David , Bjarnadottir Margret
Published: October 2024

How much information does a dataset contain about an outcome of interest? To answer this question, estimates are generated for a given dataset, representing the minimum possible absolute prediction error for an outcome variable that any model could achieve. The estimate is produced using a constrained omniscient model that mandates only that identical observations receive identical predictions, and that observations which are very similar to each other receive predictions that are alike. It is demonstrated that the resulting prediction accuracy bounds function effectively on both simulated data and real-world datasets. This method generates bounds on predictive performance typically within 10% of the performance of the true model, and performs well across a range of simulated and real datasets. Three applications of the methodology are discussed: measuring data quality, model evaluation, and quantifying the amount of irreducible error in a prediction problem.
Trade facilitation, market size, and supply chain efficiency of Taiwan semiconductor companies
Authors: Liu Cheyuan , He Tao , Liu Fangzhou , Liang Shutao , Zhang Chunyu
Published: October 2024

In an environment marked by global economic volatility and geopolitical uncertainties, the stability of Taiwan’s supply chain takes on heightened importance, particularly given Taiwan’s crucial role in the global semiconductor supply chain. In recent years, semiconductor companies in Taiwan have faced increasing inventory pressures, which will reduce their competitiveness and increase operational costs over the long term. Although previous studies have explored the influence of trade facilitation on macroeconomic and trade efficiencies, its specific impacts on the semiconductor industry have been less frequently addressed. This study integrates corporate inventory, trade facilitation, and geopolitical factors within a unified analytical framework to construct a model that explores mediating and moderating effects. This study conducted regression analysis on data from 52 Taiwan-listed integrated circuit companies from 2014 to 2022. Contrary to traditional findings that trade facilitation decreases inventory in other industries, it predominantly fosters inventory accumulation within Taiwan’s semiconductor sector by expanding market size, thereby affecting supply chain efficiency. Moreover, geopolitical factors were found to intensify the effects of trade facilitation on corporate inventory. Elevated geopolitical risks lead to greater inventory accumulation, which ultimately threatens long-term competitiveness and diminishes the semiconductor industry’s advantage in Taiwan, further influencing supply chain efficiency. Consequently, this study recommends that to more accurately forecast market size, semiconductor companies in Taiwan are encouraged to expand their manufacturing investments in Chinese mainland. Additionally, the prudent handling of cross-strait relations by the Taiwan authorities is an important strategy to mitigate geopolitical risks affecting the semiconductor supply chain.
Molecular phylogeny and cryptic morphology: A combined approach to taxonomic novelties in Polycarpaea (Caryophyllaceae) from Vietnam
Authors: Hoang Truong Thanh , Le Le Ba , Le Ngan Thi Kim , Nguyen Minh Thi Ai , Truong Anh Thi Lan , Tran Nhung Thi , Tran Vinh Thai , Le Son Van , Duong Kim Thi , Hoang Khoa Viet Bach , Le Trieu Ngoc , Nguyen Binh Van , Tran Tien Van
Published: October 2024

Three new species of Polycarpaea from Vietnam, Polycarpaea vanphongensis V.T. Tran, H.T. Truong & N.V. Binh, Polycarpaea chungana V.T. Tran, H.T. Truong & N.V. Binh, Polycarpaea phuquocensis V.T. Tran, H.T. Truong & N.V. Binh are described and illustrated based on evidence of molecular sequence data from two markers (ITS1-5.8S-ITS2 and rps16) and combined morphological characteristics. Polycarpaea vanphongensis is closely related to Polycarpaea gaudichaudi Gagnep., Polycarpaea arenaria (Lour.) Gagnep., Polycarpaea phuquocensis V.T. Tran, H.T. Truong & N.V. Binh but differs by its stem glabrous, leaf ovate to elliptic, glabrous, ovary oblong ovoid, base obtuse, apex attenuate, capsule oblong void, 3.8 mm long. Polycarpaea phuquocensis V.T. Tran, H.T. Truong & N.V. Binh differs from the three species mentioned above by its stem being densely villous, leaf spathulate, ciliate, ovary ovoid, base acute, apex obtuse, capsule ovoid, 1.2 mm long. Polycarpaea chungana V.T. Tran, H.T. Truong & N.V. Binh is most similar to Polycarpaea lignosa Gagnep., but differs in having leaf oblong or linear, sparse ciliate, sepal and petal apex deeply concaved or slightly bifid, ovary ovoid, ovoid, 0.8–1.0 mm long. Furthermore, the achievements of analysis using molecular data on the systematic positions of 7 other species are results that have not been in previous molecular analyses.
Molecular mechanism of ectopic lipid accumulation induced by methylglyoxal via activation of the NRF2/PI3K/AKT pathway implicates renal lipotoxicity caused by diabetes mellitus
Authors: Peng Chiung Chi , Chen Eugene Chang Yu , Chen Chang-Rong , Chyau Charng-Cherng , Chen Kuan-Chou , Peng Robert Y.
Published: October 2024

Patients with chronic kidney disease (CKD) have a high incidence of dyslipidemia comprising high triglyceride (TG) and low high-density lipoprotein (HDL)-cholesterol levels. An abnormal increase of TGs within cells can lead to intracellular lipid accumulation. In addition to dyslipidemia, hyperglycemia in diabetes may elicit ectopic lipid deposition in non-adipose tissues. Hyperglycemia increases intracellular levels of methylglyoxal (MG) leading to cellular dysfunction. A deficit of glyoxalase I (GLO1) contributes to dicarbonyl stress. Whether dicarbonyl stress induced by MG causes renal lipotoxicity through alteration of lipid metabolism signaling is still unknown. In this study, mice with high fat diet-induced diabetes were used to investigate the renal pathology induced by MG. NRK52E cells treated with MG were further used in vitro to delineate the involvement of lipogenic signaling. After treatment with MG for 12 weeks, plasma TG levels, renal fatty changes, and tubular injuries were aggravated in diabetic mice. In NRK52E cells, MG activated the nuclear factor erythroid 2-related factor 2 (Nrf2)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and sterol regulatory element-binding protein 1 (SREBP1), resulting in stimulation of fatty acid synthase. The intracellular accumulation of lipid droplets was mainly contributed by TGs, which increased the oxidative stress accompanied by high Nrf2 expression. In addition, MG time-dependently activated cyclin D, cyclin-dependent kinase 4 (CDK4), and cleaved caspase-3, evidencing that G0/G1 arrest was associated with apoptosis of NRK52E cells. In conclusion, our studies revealed the mechanism of lipotoxicity caused by MG. The target of such dicarbonyl stress may become a promising therapy for diabetic CKD.
Mycobacterium avium inhibits protein kinase C and MARCKS phosphorylation in human cystic fibrosis and non-cystic fibrosis cells
Authors: Kokesh Kevin J. , Bala Niharika , Dogan Yunus E. , Nguyen Van-Anh L. , Costa Marcus , Alli Abdel
Published: October 2024

In cystic fibrosis (CF), there is abnormal translocation and function of the cystic fibrosis transmembrane conductance regulator (CFTR) and an upregulation of the epithelial sodium channel (ENaC). This leads to hyperabsorption of sodium and fluid from the airway, dehydrated mucus, and an increased risk of respiratory infections. In this study, we performed a proteomic assessment of differentially regulated proteins from CF and non-CF small airway epithelial cells (SAEC) that are sensitive to Mycobacterium avium. CF SAEC and normal non-CF SAEC were infected with M. avium before the cells were harvested for protein. Protein kinase C (PKC) activity was greater in the CF cells compared to the non-CF cells, but the activity was significantly attenuated in both cell types after infection with M. avium compared to vehicle. Western blot and densitometric analysis showed a significant increase in cathepsin B protein expression in M. avium infected CF cells. Myristoylated alanine rich C-kinase substrate (MARCKS) protein was one of several differentially expressed proteins between the groups that was identified by mass spectrometry-based proteomics. Total MARCKS protein expression was greater in CF cells compared to non-CF cells. Phosphorylation of MARCKS at serine 163 was also greater in CF cells compared to non-CF cells after treating both groups of cells with M. avium. Taken together, MARCKS protein is upregulated in CF cells and there is decreased phosphorylation of the protein due to a decrease in PKC activity and presumably increased cathepsin B mediated proteolysis of the protein after M. avium infection.
How to optimise creative art therapy to foster the mental health of refugee adolescents? A Delphi study protocol
Authors: Ramadan Mohannad , Nolan Ann , Hadfield Kristin , Bosqui Tania , Ryan Meg
Published: October 2024

Objective

This study aims to identify the most recommended components of creative art therapy (CAT) to improve the mental health of refugee adolescents.

Design

A three-round Delphi design is proposed. The first round will include semi-structured interviews with a panel of 12 CAT professionals worldwide and 12 refugee adolescents aged 10–24 in Jordan with a history of participating in creative arts interventions. The hybrid approach of coding and thematic analysis will be conducted to develop statements on recommended CAT components from the interview narratives. In the second round, the same and newly enrolled 24 professionals and 24 refugee adolescents will be asked to rate the statements according to their importance, propose new statements, and add comments. A similar procedure will be followed in the third round, where panellists will rate new and old statements after perusing the feedback from the second round.

Main outcome measure

A statement will gain consensus and indicate essential components when rated ‘essential’ or ‘very important’ by > = 80% of panellists. Very important components are those with the same ratings by 60–79.9% of panellists.

Results

A list of essential and very important components, perspectives and suggestions will be provided to guide practice and intervention development.
Renal protective potential of pentoxifylline, chlorpromazine, and lovastatin in ischemia-reperfusion injury: An experimental study
Authors: Pereira Daniel Peixoto , Moreira Brunna Silva , Rodrigues Marcela Aldrovani , Magalhães Larissa Fernandes , Branco Luana de Oliveira , Reis Natani Silva , Borin-Crivellenti Sofia , Crivellenti Leandro Zuccolotto
Published: October 2024

This study aimed to evaluate the ability of pentoxifylline when compared to lovastatin and chlorpromazine as nephroprotective substances in cases of renal ischemia and reperfusion syndrome (IRI). A total of 36 adult male animals were randomly allocated into four groups (untreated control group, pentoxifylline group, lovastatin group, and chlorpromazine group), each consisting of nine animals. All groups were submitted to experimental ischemia and reperfusion procedures. The animals were evaluated 24, 72 and 120 hours after IRI, including physical examinations, serum urea and creatinine measurements, as well as histopathological, morphometric, and stereological analyses of the renal tissue. Results indicated that 24 hours after IRI, only chlorpromazine was effective in controlling azotemia. At the 72-hour mark, both chlorpromazine and pentoxifylline exhibited efficacy. After 120 hours, all three substances demonstrated renal protective qualities. Pentoxifylline was the most effective in preserving the structural integrity of kidney tissue, followed by chlorpromazine. In conclusion, all three treatments (pentoxifylline, chlorpromazine, and lovastatin) were effective. Pentoxifylline proved to be promising in the response against acute tubular necrosis, although chlorpromazine presented earlier renoprotective effects in terms of maintaining renal function.
Dual sensory impairments in companion dogs: Prevalence and relationship to cognitive impairment
Authors: Hopper Ryan G. , Bromberg Rachel B. , Salzman Michele M. , Peterson Kyle D. , Rogers Callie , Cameron Starr , Mowat Freya M.
Published: October 2024

Purpose

Many older dogs (Canis lupus familiaris) develop cognitive impairment. Dog owners often describe impairments in multiple sensory functions, yet the relationships between sensory and cognitive function in older dogs is not well understood.

Methods

We performed assessments of dog vision and hearing, both clinically (n = 91, electroretinography and brainstem auditory evoked potential) and via validated questionnaire (n = 238). We determined prevalence of sole and dual hearing/vision impairments in younger (<8 years) and older (≥8 years) dogs. Impairment cutoffs were determined using data from young dogs. We assessed the relationships between questionnaire-assessed vision and/or hearing impairments and cognitive impairment using logistic regression.

Results

Younger and older dog groups had similar distributions of sex and purebred/mixed breed status. Sex had no relationship to prevalence of sensory impairments. Older dogs had higher prevalence of hearing, vision, and dual sensory impairments, assessed both clinically and by questionnaire (P<0.001), and cognitive impairment assessed by questionnaire (P<0.001). Dogs had higher prevalence of reported cognitive impairment when owners reported dual vision and hearing impairments (79–94%, versus 25–27% in dogs with no sensory impairments), which was most consistent in dogs aged ≥8 years. In these older dogs, dual vision/hearing impairments were associated with a significantly increased risk of cognitive impairment (1.8–2.0 odds ratio).

Conclusion

Dogs aged ≥8 years are at higher risk for dual hearing/vision impairments and associated cognitive impairments. The causal relationship between these impairments is not defined, but clinical consideration of these multimorbidity risks should be made in older dogs.
Fixing imbalanced binary classification: An asymmetric Bayesian learning approach
Authors: Reis Letícia F. M. , Nascimento Diego C. , Ferreira Paulo H. , Louzada Francisco
Published: October 2024

Most statistical and machine learning models used for binary data modeling and classification assume that the data are balanced. However, this assumption can lead to poor predictive performance and bias in parameter estimation when there is an imbalance in the data due to the threshold election for the binary classification. To address this challenge, several authors suggest using asymmetric link functions in binary regression, instead of the traditional symmetric functions such as logit or probit, aiming to highlight characteristics that would help the classification task. Therefore, this study aims to introduce new classification functions based on the Lomax distribution (and its variations; including power and reverse versions). The proposed Bayesian functions have proven asymmetry and were implemented in a Stan program into the R workflow. Additionally, these functions showed promising results in real-world data applications, outperforming classical link functions in terms of metrics. For instance, in the first example, comparing the reverse power double Lomax (RPDLomax) with the logit link showed that, regardless of the data imbalance, the RPDLomax model assigns effectively lower mean posterior predictive probabilities to failure and higher probabilities to success (21.4% and 63.7%, respectively), unlike Logistic regression, which does not clearly distinguish between the mean posterior predictive probabilities for these two classes (36.0% and 39.5% for failure and success, respectively). That is, the proposed asymmetric Lomax approach is a competitive model for differentiating binary data classification in imbalanced tasks against the Logistic approach.
Development of a pharmacy-based HIV PrEP service delivery intervention for Washington, District of Columbia (DC): A study protocol
Authors: Tun Waimar , Kopeka Mamaswatsi , Conserve Donaldson F. , Gomez-Berrospi Jennifer , Janson Samuel , Johnson Courtney , Ogunbajo Adedotun , Idika Ngozi Joy , Duran Jenesis , Lendino Arianna , Bekele Bezawit , Tsao Maya Rezende , Nezam Sumaiya , Dieng Arona , Koranteng-Yorke Naana , Martin Bridget ,   BRIDGE Team, Hickson Demarc
Published: October 2024

Pharmacy-based PrEP service delivery models can help address many of the barriers that inhibit the uptake of PrEP. In an increasing number of states, legislation has been passed, or is under consideration, to allow pharmacists to initiate PrEP without a prescription from a physician or other prescriber. However, there is not yet legislation in Washington, DC to allow pharmacy-based PrEP despite its potential to curb new cases of HIV, which disproportionately affect the Black community in the area. The DC Ends HIV Plan has a goal of less than 130 new cases of HIV per year by 2030, which would require that over 13,000 high-risk residents use PrEP. However, in 2021 only 6,724 Washingtonians were taking PrEP. This study seeks to address the absence of critical formative research into the factors that would influence the implementation of pharmacy-based PrEP in Washington DC using the Implementation Mapping (IM) framework. A needs assessment will be conducted through in-depth interviews (IDIs) with pharmacists (n = 6), PrEP providers (n = 6), current PrEP users (n = 6), DC Department of Health officials (n = 2), DC Board of Pharmacy officials (n = 4) and pharmacy-based PrEP experts (n = 4) to provide input on the operational aspects of pharmacy-based PrEP model as a strategy to increase PrEP uptake. Information gathered through this needs assessment will be used to develop standard operating procedures for the introduction of pilot pharmacy-based PrEP into community-based retail pharmacies.
The value of using COVID-19 antibody tests as a potential approach to prioritize vaccination delivery
Authors: Alrabadi Nasr , Obeidat Haneen , Haddad Razan , Alyassin Noor , Alzoubi Karem H. , Obeidat Omar , Shteiwi Saif M. , Al-rabadi Daher , Al-faouri Ibrahim
Published: October 2024

Background

The highly contagious novel COVID-19 virus has demonstrated a great challenge for healthcare workers (HCWs) worldwide. One of these challenges is the availability of vaccines in some countries or societies, especially in the early stages of the pandemic.

Objectives

This study aims to determine the level of natural immunity against COVID-19 infection among HCWs exposed to COVID-19 at the early stages of the pandemic and build a model to determine the groups that can benefit more from the scarce vaccination resources.

Methods

This study took place between January and March 2021, after the first waves of the COVID-19 pandemic, before spreading the variants of concern, such as the UK variant (Alpha B.1.1.7), and before starting the vaccine campaigns. This cross-sectional study collected serum samples from 251 vulnerable HCWs. The samples were tested for IgG antibodies against COVID-19 using commercial kits. The demographics and clinical characteristics of the participants were recorded using face-to-face interviews.

Results

COVID-19 IgG antibodies were detected in more than 40% of HCWs before vaccination. Those HCWs should have less priority than those without COVID-19 IgG. The seroprevalence of COVID-19 was higher in male HCWs and among nurses. There was no association between the participants’ immunity and smoking status or different blood groups. Most HCWs reported being infected with the virus during the first wave, mainly at the end of 2020. A limited number of HCWs reported infections between January 2021 and March 2021. All HCWs eventually received the COVID-19 vaccine, ignoring being previously infected.

Conclusion

The reported results emphasize the value of using immunity tests to prioritize the groups that may benefit the most from the limited vaccines, especially in developing countries with scarce resources where those with COVID-19 IgG antibodies should have less priority for the COVID-19 vaccine. The present results indicate that up to 40% of the delivered vaccines to HCWs who had COVID-19 antibodies could be prioritized more wisely in future pandemics.
Fluctuation of functional somatic disorders in a population-based cohort. The DanFunD study
Authors: Schovsbo Signe U. , Kårhus Line L. , Bjerregaard Anne A. , Petersen Marie W. , Frostholm Lisbeth , Fink Per , Carstensen Tina B. W. , Eplov Lene F. , Benros Michael E. , Brix Susanne , Madsen Anja L. , Linneberg Allan , Dantoft Thomas M. , Jørgensen Torben
Published: October 2024

Background

Evidence of incidence of functional somatic disorders (FSD) is hampered by unclear delimitations of the conditions and little is known about the possible interchangeability between syndromes. Further, knowledge on remission and persistence of FSD in the general population is limited. We aimed to assess the natural course of various FSD over 5 years in the general population.

Methods

A follow-up study (Danish Study of Functional Disorders—DanFunD) was conducted in a random sample of the general population comprising 5,738 participants aged 18–76 years at baseline. Both at baseline and five-year follow-up, participants filled in validated questionnaires on symptoms to delimitate two approaches of FSD, the bodily distress syndrome (BDS) and four functional somatic syndromes (FSS): irritable bowel (IB), chronic fatigue (CF), chronic widespread pain (CWP), and multiple chemical sensitivity (MCS).

Results

Both BDS and FSS showed a five-year incidence around 11%. Incidence of the individual FSS varied from 0.8% (MCS) to 5.7% (CF). BDS and FSS showed a remission proportion close to 50%. We found a high degree of interchangeability between each FSS varying from 15.0% to 23.4%.

Conclusion

We identified a marked fluctuation pattern of FSD during a five-year period, with a high degree of interchangeability between each FSS. The study stresses the importance of large population-based cohorts with transparent delimitation of FSD in future research to understand these complex conditions.
Insights into artificial waterhole utilization patterns by elephants and rhinos: Lessons from a South African Nature Reserve
Authors: Smith Eilidh , Brown Leslie Robert , Barrett Alan Sean
Published: October 2024

Artificial water provisioning is a common practice in southern African nature reserves, where different game species exhibit preferences for specific waterhole types. The movement patterns and behaviour of elephants and rhinos are closely linked to water availability, with these mega-herbivores noticeably influencing the environment and other species they interact with at waterholes. Since there is limited research on this topic, understanding preferences for different types of artificial waterholes is crucial, particularly during periods of water scarcity. This knowledge enables reserve managers to effectively manage the numbers and types of waterholes. In this study, we investigate artificial waterhole selection and preferences by elephants and rhinos in the Olifants West Nature Reserve, South Africa. The study area featured various waterhole types, including earth dams, concrete pans, reservoirs, and troughs. By employing camera traps, we analysed visitation frequency, timing of visits, and factors influencing visit frequency. Our findings revealed distinct preferences for specific waterhole types among different social groupings of the study species. Breeding herds of elephants predominantly utilized reservoirs and occasionally visited troughs, while bachelor herds favoured earth dams. Black rhinos showed a preference for earth dams, whereas white rhinos selected troughs and earth dams, with bachelor groups favouring troughs and female rhinos favouring earth dams. The outcomes of this study have significant implications for the development of comprehensive conservation plans in areas where these species reside, and for potential release sites.
Prevalence of hypertension and factors associated with the utilization of primary health care services for hypertension among hypertensive population aged 40 years and above in Pyin Oo Lwin Township, Myanmar
Authors: Soe May Sabai , Hlaing Su Su , Mon Aye Sandar , Lynn Kyaw Thu
Published: October 2024

Background

Utilization of hypertension services at primary health care levels has not been assessed at township level, since launching of PEN interventions in Myanmar. This study aimed to determine the factors associating with the utilization of primary health care services for hypertension among 40 years and above hypertensive population.

Methods

Community-based cross-sectional study was done in Pyin Oo Lwin Township, 2023. Multi stage sampling was conducted to recruit 40 years and above participants; response rate was 85%. Joint National Committee (JNC7) classification was used to define hypertension. Among hypertensive participants, descriptive analysis, Chi squared test and multiple logistic models were conducted, with a significance level of 0.05.

Results

Out of 1001 screening participants, prevalence of hypertension was 38.6% (386). Among 386 participants, 51.8% (200) utilized primary health care services provided by public health facilities. Rural residents (AOR = 2.79, CI = 1.68, 4.67), known hypertension (AOR = 4.36, CI = 2.39, 8.23), good perception on hypertension (AOR = 0.30, CI = 0.14, 0.62), perceived cost of travel as necessary (AOR = 0.57, CI = 0.35, 0.92) and awareness of available services (AOR = 4.11, CI = 2.55, 6.71) were associated with the utilization of primary health care services for hypertension.

Conclusion

This study provided context-specific scientific evidence to tackle existing problems of low utilization of PHC services for hypertension. Strengthening health care infrastructure for quality hypertension care at primary health care level was also recommended.
Long-term efficacy and safety of ab externo canaloplasty in the Polish Caucasian population with open-angle glaucoma: A 3-year retrospective study
Authors: Konopińska Joanna , Gołaszewska Kinga , Saeed Emil
Published: October 2024

This study aimed to assess the effectiveness and safety of ab externo canaloplasty over a 3-year follow-up period in Polish Caucasian patients with glaucoma. This retrospective study of a cases series was conducted at the Department of Ophthalmology Medical University of Bialystok, Poland. Primary outcome measures were intraocular pressure and medication burden. Secondary outcome measures were best corrected visual acuity, retinal nerve fiber layer thickness, visual field test results, endothelial cell density, intraoperative and postoperative complications, and additional glaucoma surgery. The study group consisted of 160 eyes diagnosed with early to-moderate primary open-angle glaucoma and treated with ab externo canaloplasty from 2014 to 2020. The criteria for qualified and complete success were intraocular pressure < 18 mmHg or ≥ 20% reduction in intraocular pressure from baseline with or without antiglaucoma medications, respectively. After surgery, the mean intraocular pressure decreased from 19.23 ± 4.33 to 14.52 ± 3.79 mmHg, which constituted a 36.7 ± 7.8% reduction compared to the baseline value. The number of medications decreased by two at the end of the study period (from 2.69 ± 1.05 to 0.32 ± 0.75). Complete and qualified success were achieved in 58.7% and 68.7% of the patients, respectively, at the end of follow-up. An incomplete cannulation of Schlemm’s canal was the most common intraoperative complication, occurring in 32 eyes (20%). The most frequent postoperative complications were hyphema, Descemet’s membrane detachment, and a transient increase in intraocular pressure. Additional surgical procedure was required in seven cases (4.4%). In 16 patients (10%), medical treatment was re-administered. Overall, our findings suggest that ab externo canaloplasty is a good option for Polish Caucasian patients with primary open-angle glaucoma. It reduces intraocular pressure and has a low postoperative complication rate. Additional glaucoma surgery or re-administration of medications is required if the target intraocular pressure is unsatisfactory.
Arendt alumna de Husserl
Authors: Serrano de Haro Martínez Agustín
Published: October 2024

Mi ensayo reconstruye el curso universitario de Edmund Husserl que la joven Arendt escuchó en el semestre de invierno 1926/27 en la ciudad de Friburgo. Estas lecciones de “Introducción a la fenomenología” no han merecido atención ni de la literatura secundaria en torno a Husserl, dado que sólo disponemos de fragmentos del curso, ni de aquella en torno a Arendt, que da por descontado el que fueron irrelevantes para su trayectoria filosófica. El curso ofreció, sin embargo, una inmersión profunda en la configuración madura de la fenomenología e incluyó una discusión avanzada de la problemática de la corporalidad y la intersubjetividad. Lo cual permite una nueva mirada sobre la posible latencia de motivos husserlianos en temas importantes del pensamiento arendtiano. Esta posibilidad se comenta aquí en cinco hipótesis finales, que culminan en la meditación de La vida del espíritu sobre la naturaleza fenoménica del mundo.
Medical Therapies for Prevention and Treatment of Inflammatory Pouch Disorders—A Systematic Review and Meta-Analysis
Authors: Syal Gaurav , Barnes Edward , Raffals Laura , Al Kazzi Elie , Haydek John , Agarwal Mansai , Singh Siddharth
Published: October 2024

INTRODUCTION:

Pouchitis and Crohn's-like disease of the pouch (CLDP) are common in patients who undergo ileal pouch anal anastomosis for ulcerative colitis. We conducted separate systematic reviews to evaluate the effectiveness of available interventions to prevent and treat pouchitis and CLDP.

METHODS:

Through systematic literature reviews, we identified studies that evaluated the effectiveness of probiotics, antibiotics, 5-aminosalicylates, nonsystemic oral corticosteroids, and advanced therapies for prevention and treatment of pouchitis and CLDP for meta-analysis. Primary outcomes were occurrence of pouchitis for pouchitis prevention and clinical response for pouchitis and CLDP treatment. We estimated the relative effectiveness of these interventions using the existing placebo response rates or hypothetical spontaneous improvement rates derived from clinical trials of pouchitis, ulcerative colitis, and Crohn's disease.

RESULTS:

Probiotics were effective for primary (relative risk [RR] 0.18; 95% confidence interval [CI] 0.05–0.62) and secondary prevention (RR 0.17; 95% CI 0.09–0.34) of pouchitis. Antibiotics were effective for treatment of acute and chronic pouchitis (12 cohorts; RR 1.67; 95% CI 1.34–2.01; response rate 65%; 95% CI 52–75) with ciprofloxacin and metronidazole-based regimens being more effective than rifaximin. Advanced therapies were effective for treatment of chronic antibiotic-refractory pouchitis (31 cohorts; RR 1.71; 95% CI 1.28–2.56; response rate 50%; 95% CI 43–57) and CLDP (10 cohorts; RR 2.49; 95% CI 1.87–3.73; response rate 74%; 95% CI 68–79) without significant difference between classes.

DISCUSSION:

Multiple medical interventions are effective for prevention and treatment of pouchitis and CLDP. Given the overall low quality of data, further research is needed to confirm these findings.
On Province and Empire in My Ántonia and One of Ours: Cather’s 1922 The Waste Land
Authors: Olson Paul A.
Published: October 2024

Willa Cather profoundly alters her attitude towards the American experiment, World War I, and the prospect of cultural pluralism in America between her 1918 My Ántonia and her 1922 One of Ours. In doing so, she addresses the issue of what kind of culture America should have: a monistic one such as Theodore Roosevelt and Woodrow Wilson advocated or a pluralistic one. In My Ántonia, set during the period of Great Plains settlement but extending up into World War I, she presents an intact American cultural pluralism: non-English speaking European cultures continuing their positive practices absent the monarchic repression of Central European empires. Her ethnic settlements in the Great Plains practice pluralistic democracy without intervention from centralised authority, implicitly reflecting what could happen under an emerging European anti-monarchic ethos or in an America that allowed for many ways of life. In One of Ours, on the other hand, she savages the jingoism that possessed America during, and after World War I: a repression that makes the war disastrous for pluralistic democracy. The dream falters. Her wartime Nebraska becomes repressive for Germans, Czechs, and other divergent peoples. It practices conformity, a new materialism, and meaningless religion. Indeed, the death of her novel’s hero, Claude Wheeler, is not a sacrifice that enables democratic renewal but rather offers us a self-blinded hero who dies in glorious strife only as he sees it. He actually dies for a nation increasingly making itself unsafe for democracy in an army whose soldiers are massively disillusioned by the war. Thereafter, Cather writes little in a positive vein of Nebraska or the Great Plains and its various cultures but turns to earlier New World catalyst communities such as those of Quebec, the pueblos of the Southwest, and pioneer New Mexico.
“Can Corpses Undie?” Traces of Rothberg’s Trauma Model in Faridah Àbíké-Íyímídé’s Ace of Spades
Authors: Ayodeji Adewuyi Aremu
Published: October 2024

Interdisciplinary studies in memory have become more relevant since the turn of the twentieth century with scholars giving their divergent views. That way, personal and collective memories have been explored vis-à-vis communal identities. How tragic/traumatic events affect personal and collective memories remains the concern of trauma theory which has critically investigated both the personal and intergenerational traumas of victims of injustice. One major contribution of Michael Rothberg to collective memory is his advancement of solidarity between group victims of diverse cultures, nationalities, races, and identities in order to create a more peaceful world to live in. This paper purports that Rothberg’s multidirectional memory and theory of implication are useful theoretical tools for analysing Faridah Àbíké-Íyímídé’s Young Adult novel, Ace of Spades (2021). The paper, therefore, indicates how diverse sites of trauma in the author’s world synergise with those of the protagonists. Also, the paper notably identifies some white characters in Ace of Spades as implicated subjects of racism and white supremacy. On the whole, the premise of this paper is that the new media can serve as a convenient site of thoughtful convergence for different victim groups to devise a means of dismantling long-existing regimes of oppression and injustice.
Fulfilling data access obligations: How could (and should) platforms facilitate data donation studies?
Authors: Hase Valerie , Ausloos Jef , Boeschoten Laura , Pfiffner Nico , Janssen Heleen , Araujo Theo , Carrière Thijs , de Vreese Claes , Haßler Jörg , Loecherbach Felicia , Kmetty Zoltán , Möller Judith , Ohme Jakob , Schmidbauer Elisabeth , Struminskaya Bella , Trilling Damian , Welbers Kasper , Haim Mario
Published: October 2024

Research into digital platforms has become increasingly difficult. One way to overcome these difficulties is to build on data access rights in EU data protection law, which requires platforms to offer users a copy of their data. In data donation studies, researchers ask study participants to exercise this right and donate their data to science. However, there is increasing evidence that platforms do not comply with designated laws. We first discuss the obligations of data access from a legal perspective (with accessible, transparent, and complete data as key requirements). Next, we compile experiences from social scientists engaging in data donation projects as well as a study on data request/access. We identify 14 key challenges, most of which are a consequence of non-compliance by platforms. They include platforms’ insufficient adherence to (a) providing data in a concise and easily accessible form (e.g. the lack of information on when and how subjects can access their data); (b) being transparent about the content of their data (e.g. the lack of information on measures); and (c) providing complete data (e.g. the lack of all available information platforms process related to platform users). Finally, we formulate four central recommendations for improving the right to access.
Balancing public interest, fundamental rights, and innovation: The EU’s governance model for non-high-risk AI systems
Authors: Gille Michael , Tropmann-Frick Marina , Schomacker Thorben
Published: October 2024

The question of the concrete design of a fair and efficient governance framework to ensure responsible technology development and implementation concerns not only high-risk artificial intelligence systems. Everyday applications with a limited ability to inflict harm are also addressed. This article examines the European Union's approach to regulating these non-high-risk systems. We focus on the governance model for these systems established by the Artificial Intelligence Act. Based on a doctrinal legal reconstruction of the rules for codes of conduct and considering the European Union's stated goal of achieving a market-oriented balance between innovation, fundamental rights, and public interest, we explore our topic from three different perspectives: an analysis of specific regulatory components of the governance mechanism is followed by a reflection on ethics and trustworthiness implications of the EU´s approach and concluded by an analysis of a case study from an NLP-based, language-simplifying artificial intelligence application for assistive purposes.