bluuebunny/crossref_metadata_2025 huggingface dataset:
La literatura y el ocio de la sociedad cortesana del Siglo de Oro | Jesús Gómez, Salamanca, Universidad de Salamanca, 2021, 202 pp.
Authors: Baranda Leturio Consolación
Published: January 2024

Reseña: La literatura y el ocio de la sociedad cortesana del Siglo de Oro | Jesús Gómez, Salamanca, Universidad de Salamanca, 2021, 202 pp.
Literatura italiana del seiscientos y filología de autor: tres ejemplos (Marino, Stigliani, Tesauro)
Authors: Carminati Clizia , Landi Marco , Chiesa Federica , Cutrì Maicol
Published: January 2024

Para el siglo XVII la filología de autor registra, con escasas excepciones, una penuria tanto de ediciones modernas y críticas como de estudios filológicos. Los tres casos que se estudian aquí, aunque muy diferentes entre sí, muestran cómo la investigación en este campo permite reunir valiosa información sobre la forma de trabajar de los autores del Barroco. Por lo que atañe a Marino, se revisa la situación de las Rime, la Galeria y el Adone y se brinda una primera valoración de las circunstancias y de los problemas de la tradición textual, a partir de los varios tipos de documentos supérstites (originales y ediciones al cuidado del autor). En cuanto a Stigliani, se ofrece una visión general de la gran variedad de materiales hoy disponibles: impresos, manuscritos y apostillas, que atestiguan un incansable proceso de reelaboración, en el cual influyeron de forma acusada las vicisitudes personales del propio escritor. El caso de Tesauro, finalmente, se presenta a través de su obra más conocida, Il Cannocchiale aristotelico, para la cual el cotejo de las ediciones significativas ha puesto de relieve las variaciones tanto en la estructura general del libro como en porciones aisladas del texto.
Premisa para una filología de autor aplicada a textos italianos del Siglo de Oro
Authors: Albonico Simone
Published: January 2024

Introducción
Sobre España en el largo siglo XVIII | Juan Díaz Álvarez, Fernando Manzano Ledesma, Rodrigo Olay Valdés (coords.), Gijón, Ediciones Trea, 2021, 669 pp.
Authors: Sánchez Pascual Pablo
Published: January 2024

Reseña a: Sobre España en el largo siglo XVIII | Juan Díaz Álvarez, Fernando Manzano Ledesma, Rodrigo Olay Valdés (coords.), Gijón, Ediciones Trea, 2021, 669 pp.
La zarzuela en Sevilla. Crónicas musicales atribuidas a Gustavo Adolfo Bécquer | Marta Palenque y Andrés Moreno Mengíbar, Sevilla, Diputación de Sevilla, Colección Arte Hispalense, 2022, 182 pp.
Authors: Bordons Ortiz César de
Published: January 2024

Reseña a: La zarzuela en Sevilla. Crónicas musicales atribuidas a Gustavo Adolfo Bécquer, Marta Palenque y Andrés Moreno Mengíbar, Sevilla, Diputación de Sevilla, Colección Arte Hispalense, 2022, 182 pp.
Un único corazón | Alejandro Duque Amusco, Valencia, Pre-textos, 2022, 88 pp.
Authors: Balcells Domenech José María
Published: January 2024

Reseña a: Un único corazón, Alejandro Duque Amusco, Valencia, Pre-textos, 2022, 88 pp.
Auto-biografismo por omisión: retrato familiar a trazo limpio en El buen padre de Nadia Hafid
Authors: Rodrigues Judite
Published: January 2024

El título de la primera novela gráfica de Nadia Hafid (El buen padre, Barcelona, Sapristi Editorial, 2020) es una declaración de respeto y comprensión, un marbete —en mayúsculas y sin matiz— que rechaza el rencor y la amargura: el buen padre. Se trata de la historia de un abandono: la capitulación de un padre, inmigrante marroquí, que regresa a su país dejando atrás a su mujer y sus tres niños. Algunas páginas documentan con sencillez la realidad de la inmigración —entre derrota y violencia— y la situación enquistada de quien no consigue arraigarse. Pero, más allá de la sola figura paterna, la autora dibuja un retrato familiar que aborda las complejidades de las ausencias, las pérdidas, las personalidades moldeadas por esas herencias y heridas. Nadia Hafid firma una obra con carácter claramente autobiográfico. El presente artículo analiza cómo la autora aborda el género autobiográfico explorando formas nuevas de narración y apostando por un lenguaje gráfico original. El estudio indaga de qué forma la sobriedad gráfica permite plasmar la ausencia de un padre cuya figura espectral recorre toda la obra.
Escritos de Pío Baroja en la prensa española desde el final de la Guerra Civil hasta 1955. Recuperación de los desconocidos
Authors: García de Juan Miguel Ángel
Published: January 2024

El presente artículo informa de los escritos periodísticos de Pío Baroja, casi todos procedentes de antetextos, a partir de su regreso de Francia en 1940, tras cuatro años de exilio voluntario en nuestro país vecino. Después de contextualizarlos dentro de su obra de aquel periodo, se reproducen en un apéndice los escasos que no procedían de una versión anterior, o sea, los redactados poco tiempo antes de publicarse. Finalmente, se añade un anexo con el listado de los casi doscientos que no se habían atendido y que se difundieron en prensa, señalando la cabecera de donde fueron extraídos, la fecha de su publicación y el medio que los reprodujo.
José de Siles. Poemas y cuentos de la bohemia | Emilio José Ocampos Palomar (ed.) Córdoba, UCOPress, 2023, 146 pp.
Authors: Palenque Marta
Published: January 2024

Reseña de José de Siles. Poemas y cuentos de la bohemia |Emilio José Ocampos Palomar (Ed.)Córdoba, UCOPress, 2023, 146 pp.
"Tu mudo horror divino". Góngora y el horror sagrado
Authors: Huergo Humberto
Published: January 2024

A pesar de la atención recibida, el soneto “Restituye a tu mudo horror divino” sigue planteando toda clase de interrogantes. El objetivo de este trabajo es ofrecer una interpretación rigurosa del texto, que tenga en cuenta no sólo el aspecto filológico, sino también el filosófico, muy en particular la sublimidad del horror.
Rinconete y Cortadillo: los juegos de la creación
Authors: Laspéras Jean Michel
Published: January 2024

En La novela de Rinconete y Cortadillo, el análisis de la creación de los personajes y sus respectivos diálogos enseña cómo Cervantes se fundó no sólo en la Miscelánea de Luis Zapata, sino en obras como El Galateo español de Gracián Dantisco o Propos rustiques de Noël du Fail, que pudo conocer gracias al bibliópola e impresor Andrea Pescioni. Las tres, en el crisol de la inventiva del alcalaíno, contribuyen al amanecer de una nueva poética.
¡Pícaros a escena! Teatralizaciones de la novela picaresca en el siglo XXI
Authors: Conejero Alberto , Fontseré Ramón , Sánchez Arnosi Milagros , Tato Álvaro , Soledad Arredondo María
Published: January 2024

Este artículo a diez manos recoge una de las conferencias y sendas entrevistas-diálogo de la jornada ¡Pícaros a escena! Teatralizaciones de la novela picaresca en el siglo XXI, celebrada en la Posada del Potro de Córdoba el 9 de diciembre de 2022. Se fundan sobre la adaptación de El coloquio de los perros de Miguel de Cervantes por Els Joglars (Albert Boadella y Ramón Fontseré) (2014), la reescritura de Rinconete y Cortadillo (también del autor de las Novelas ejemplares) a cargo de Alberto Conejero (2016) y el bastidor de La pícara Justina de Francisco López de Úbeda, La hija de Celestina de Alonso Jerónimo de Salas Barbadillo y La niña de los embustes. Teresa de Manzanares de Alonso de Castillo Solórzano en Malvivir (2022) de Álvaro Tato y Ron Lalá.
Doenças diagnosticadas pelo Laboratório de Patologia Veterinária em 2021
Authors: Miglioranza Cesar Augusto , Neumann Schuck Bruna Luiza , Pelisser Giovana , Horn Vitor Waldir , Begnini Ana Flavia , Gomes Teane Milagres Augusto , Mendes Ricardo Evandro
Published: January 2024

Este trabalho apresenta a casuística de diagnósticos no ano de 2021 do Laboratório de Patologia Veterinária do IFC Campus Concórdia. Foram 247 diagnósticos em bovinos, 32 em ovinos e 14 em suínos, totalizando 293. Destes, 264 (90,1%) foram através de necropsias e 29 (9,9%) através de amostras formolizadas enviadas por veterinários. Em bovinos as doenças mais incidentes foram retículo peritonite traumática, intoxicação por nitrato/nitrito e leucose enzoótica bovina com 16 casos (6,5%) cada; miosite clostridial com 15 casos (6,1%); seguido por uma doença granulomatosa idiopática, com 13 casos (5,3%). Já em ovinos o diagnóstico mais prevalente foi a intoxicação por nitrato/nitrito com 18 necropsias (56,3%).
Surto de polioencefalomalácia em bovinos de corte em Santa Catarina
Authors: Horn Vitor Waldir , Perosa Fernanda Felicetti , Gimenes da Silva Isabela , Mingotti Taisson Rafael , Gris Ladi , Bianchi Ronaldo Michel , Gomes Teane Milagres Augusto , Mendes Ricardo Evandro
Published: January 2024

Polioencefalomalácia (PEM) é o diagnóstico morfológico para necrose com amolecimento (malácia) da substância cinzenta (pólio) do encéfalo. O termo PEM foi inicialmente empregado no Colorado (EUA) em 1956 para designar uma doença específica de ruminantes, e não somente uma lesão, presumivelmente causada por deficiência de tiamina e caracterizada por necrose do córtex telencefálico. Inúmeras causas já foram descritas como causadoras de PEM em ruminantes. O objetivo deste trabalho foi relatar um surto de polioencefalomalácia em bovinos de corte ocorrido no ano de 2019 no município de Xavantina, estado de Santa Catarina, Brasil. Os dados epidemiológicos e clínicos foram obtidos durante uma série de visitas à propriedade do surto, em Xavantina. Foram realizadas necropsias de quatro bovinos adultos. Fragmentos de órgãos foram colhidos, fixados em formol 10%, processados rotineiramente para histopatologia e corados com Hematoxilina e Eosina (HE). De um rebanho de 50 animais criados a campo em sistema de piquetiamento, em um período de uma semana, oito animais morreram e 16 apresentaram sinais clínicos. O diagnóstico definitivo de PEM foi estabelecido através da associação dos sinais clínicos e lesões microscópicas, assim como pela melhora clínica dos bovinos após a administração de tiamina. No LPV do Instituto Federal Catarinense (IFC) a incidência de PEM, de janeiro de 2013 a dezembro de 2022, é de 1,2%; ou seja, dos 2.162 bovinos diagnosticados no período, 17 fora necropsiados por PEM. Conclui-se que a PEM é um importante diferencial a ser considerado em casos de sinais clínicos nervosos em bovinos no estado de Santa Catarina, visto que é factível o tratamento de bovinos com administração de tiamina.
Estudo retrospectivo dos casos de endocardite diagnosticados em bovinos pelo LPV-IFC em Santa Catarina (2013-2022)
Authors: Tonin Raphael Adenir Valeriano , Boldori Érica , Drechmer Natacha , Silva Isabela Gimenes da , Carneiro Christophe , Werlang Rafael André , Bianchi Ronaldo Michel , Ascoli Baldi Kelen Regina , Gomes Teane Milagres Augusto , Mendes Ricardo Evandro
Published: January 2024

Endocardite bacteriana é uma das principais enfermidades cardíacas que acomete bovinos leiteiros adultos. Processos sépticos, como metrite, mastite, pododermatites, abcessos no fígado e peritonite traumática, estão fortemente relacionados com a ocorrência da enfermidade em bovinos. O objetivo deste trabalho foi relatar os casos de endocardite bacteriana em bovinos diagnosticados pelo Laboratório de Patologia Veterinária do Instituto Federal Catarinense (LPV-IFC) - Campus Concórdia. No período estudado (2013-2022) foram realizadas 1.769 necropsias de bovinos; destas, 51 (2,88%) foram diagnosticadas como endocardite. A valva atrioventricular direita foi a mais acometida (38/51), e em 23 dos 38 casos, além da tricúspide, havia a ocorrência simultânea em outras valvas. O segundo local mais acometido foi a valva atrioventricular esquerda (20/51). A valva bicúspide teve acometimento concomitante com a valva atrioventricular direita em 17 necropsias. Doenças síncronas foram encontradas em 18 casos, sendo a retículo peritonite traumática (4/18) a mais frequente, seguida por úlcera de abomaso (3/18). Conclui-se que a proporção de casos em relação ao total de diagnósticos em bovinos no IFC (2,88%), foi comparativamente maior a de outros laboratórios de diagnóstico do sul do Brasil: 1,0% e 2,5%, sendo necessário que técnicos e produtores rurais adotem de medidas de prevenção e controle dessa enfermidade.
RETRACTED: Malaysian Hospitals on the Web: a Multi-Criteria Assessment of Official Websites
Authors: Sarantis Demetrios , Musizvingoza Ronald , Shameeta Masilamany , Soares Delfina , Carvalho Joana
Published: January 2024

The authors have requested that this preprint be removed from Research Square.
Numerical Simulation of Turbulent Premixed CH4-H2 Flames in a High Pressure Swirl Burner for Gas Turbine Applications
Authors: ouali sofiane
Published: January 2024

This 3D numerical study investigates the combustion characteristics of methane-hydrogen blends in a high-pressure swirl burner for gas turbine applications. Hydrogen concentration is varied from 0% to 50% in steps of 5 % by volume for four thermal power levels (42KW, 84 KW, 126 KW, and 168 kW). The other parameters such as the inlet temperature as well as the fuel-air ratio were kept constant in order to analyze only the effect of the H2 addition and the power variation. Results demonstrate hydrogen enrichment mildly increases flame temperature and stabilizes the reaction zone without significantly disturbing the flow field. All cases exhibit coherent temperature evolution and steady flame fronts. NOx production shows an acceptable rise with hydrogen addition peaking at 6.2 ppm for 168 KW power and 50 % of H2. Results suggest this burner geometry can stably operate on methane-hydrogen mixtures up to 50% by volume hydrogen across a wide power band, offering promising prospects for gas turbine fuel flexibility.
Numerical simulation of droplet formation in a Co-flow microchannel capillary device
Authors: Zhang Peihua , Ma Yongbiao , Song Bao , Chen Dengke , Zhang Dengying , Yuan Jinliang , Wang Meichun , Chen Xueye
Published: January 2024

In this article, a numerical simulation of the droplet formation in a Co-flow microchannel capillary device, and the influencing factors of the formation of droplets are studied. The level set method is used to track the two-phase interface and droplet formation. In the Co-flow focusing device, we explored the influencing factors of the size of the generated droplets. The results show that as the ratio of the dispersed phase velocity to the continuous phase velocity increases, the volume of the generated droplets decreases significantly, the droplet generation frequency increases significantly, and the pressure of the droplets at the centerline decreases significantly. As the viscosity of continuous phase increases, the volume of generated droplets decreases significantly, the frequency of droplet generation increases significantly, and the pressure of droplets at the centerline decreases significantly. As the contact angle between the continuous phase and the wall increases, the volume of the generated droplets increases, but the volume increase is not obvious enough, the droplet generation frequency becomes smaller, and the droplet pressure at the centerline decreases. As the increase of interfacial tension, the volume of droplet generation increases significantly, the frequency of droplet generation decreases significantly, and the pressure of droplet at the centerline increases significantly.
A Novel Brain Mapping Method without Predetermined Targets Using Hyperspectral Microscopy
Authors: Oka Kotaro , Inoue Shunsei , Inda Masahiro , Hotta Kohji
Published: January 2024

Simple and efficienttechniques to produce brain maps are required for current neuroscience research. We developed a novel pipeline called Hyperspectral Phasor Mapping (HySP-Map) to map unstained brain sections using a hyperspectral camera. Our camera can acquire 125 bands of spectral information from 380 nm − 1000 nm. The HySP-Map obtains the transmittance from the division of the background image and the sample image and applies the phasor method. The maps produced by HySP-Map for mouse brain sections were of comparable quality to existing brain maps. We also successfully applied HySP-Map to the bird brain, validating its applicability across considerably different species. Moreover, we compared the results from HySP-Map with those of existing tissue staining techniques, and it demonstrated a high degree of reproducibility. This indicates that HySP-Map may be able to visualize brain areas that have not been previously identified.
Efficient Removal of Amoxicillin, Ciprofloxacin, and Tetracycline from Aqueous Solution Utilizing Cu-doped Bi2O3 Material
Authors: Saadah Fatkhiyatus , Sutanto Heri , hadiyanto hadiyanto , Alkian Ilham
Published: January 2024

This study investigates the effectiveness of the Cu-doped Bi2O3 method for removing antibiotics. Cu at varying concentrations of 0%, 2%, 4%, 6%, and 8% was used to synthesize Bi2O3 material successfully. The optimal results were obtained by adding 4% Cu to the Bi2O3 matrix. Cu-doped Bi2O3 was characterized by an energy band gap of 2.32 eV, a crystal size of 37.04 nm, and α- Bi2O3 and Rouaite phases. Material containing Cu-doped Bi2O3 was used to degrade antibiotics such as amoxicillin (AMX), ciprofloxacin (CIP), and tetracycline (TC). The various removal techniques investigated include adsorption, photolysis, and photocatalysis. The photocatalytic procedure yielded the highest results in terms of degradation efficiency. The removal efficiency of each antibiotic using the photocatalytic method varies, with AMX at 52.06%, CIP at 61.72%, and TC at 69.44%. Cu-doped Bi2O3 degraded TC-type antibiotics more rapidly, with a reaction rate constant of 0.0065 minutes− 1, according to the results of the reaction rate constants. The high removal efficiency and rapid reaction rate indicate that Cu-doped Bi2O3 is an effective antibiotic removal agent, especially for tetracycline-type antibiotics.
Design of Sulfonamide Substituted Mono-Azo Derivatives: Photophysical and Biological Activity
Authors: Shekharagouda Pampapathi , P Mamatha G , KM Pallavi , Krishnamurthy Chethan , Sajjan Vinodkumar P. , Al-Asbahi Bandar Ali , Al-Hada Naif Mohammed , Naik Lohit
Published: January 2024

Novel Azo-linked substituted sulfonamides were synthesized via diazo coupling reactions and characterized by FT-IR, UV-vis, HR-MS and 1H NMR spectroscopic techniques. The newly synthesized compounds were examined for their in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli strains using the disc-agar diffusion method, the dye F1 exhibited more zone inhibition 25mm in the concentration 75µl/ml in gram-negative bacteria when compared with common antibiotic Ciprofloxacin. The photophysical properties was estimated using DFT-B3LYP-6-31 + G (d) basis set. The correlation between the HOMO LUMO energy gap and antibacterial activity was investigated computationally. Additionally, in silico molecular docking was carried out. Among four compounds, compound F2 has the highest binding energy against cyclin dependent kinase (ΔGb = -9.8 kcal/mol).
Modelling the potential clinical and economic impact of universal immunisation with nirsevimab versus standard of practice for protecting all neonates and infants in their first respiratory syncytial virus season in Spain
Authors: Gil-Prieto Ruth , Pérez Jaime Jesus , Drago Georgina , Kieffer Alexia , Roïz Julie , Kazmierska Paulina , Sardesai Aditya , Boisvilliers Solène , López-Belmonte Juan Luis , Beuvelet Matthieu , Aldean Javier Alvarez
Published: January 2024

Background
Respiratory syncytial virus (RSV) is associated with substantial morbidity among infants. This study modelled the potential public health and economic impact of nirsevimab, a long-acting monoclonal antibody, as an immunoprophylactic strategy for all infants in Spain in their first RSV season.
Methods
A static decision-analytic model of the Spanish birth cohort during its first RSV season was developed to estimate the impact of nirsevimab on RSV-related health events and costs versus the standard of practice (SoP). Spain-specific costs and epidemiological data were used as model inputs. Modelled outcomes included RSV-related outpatient visits, emerging room (ER) visits, hospitalisations – including pediatric intensive care unit (PICU) admission, mechanical ventilation, and inpatient mortality.
Results
Under the current SoP, RSV caused 145104 primary care visits, 37978 ER visits, 12911 hospitalisations, 1415 PICU admissions, and 17 deaths over a single season, representing a cost of €68.4 million from a healthcare payer perspective. Universal immunisation of all infants with nirsevimab was expected to prevent 99433 primary care visits (68.5% reduction), 26030 ER visits (68.5%), 8754 hospitalisations (67.8%), 934 PICU admissions (66.0%), and 9 inpatient deaths (56.5%), saving €45.6 million (66.7%) in healthcare costs.
Conclusions
These results suggest that immunisation with nirsevimab of all infants experiencing their first RSV season in Spain is likely to prevent thousands of RSV-related health events and save considerable costs versus the current SoP.
Fire effects on plant communities in Ozark woodlands and glades
Authors: Stephen Carolyn A. , Drees Dan G. , Ladner Jamie H. , Sullivan Lauren L.
Published: January 2024

Background
Decades of fire suppression have caused drastic changes to community structure and composition across ecosystems, including in Ozark woodlands in the central Midwestern United States. Reintroducing fire can restore ground flora by reducing midstory tree density, increasing ground layer light, and reducing leaf litter accumulation, but we lack a clear understanding of how these effects vary across time and space. We investigated the effects of repeated prescribed fire on ground flora species richness, floristic quality, abundance, community composition, and stand structure over 20 years in a landscape matrix of glades, dry woodlands, and dry mesic woodlands using data collected from the Ozark National Scenic Riverways Fire Effects Monitoring program in the Current River Watershed in the Missouri Ozarks.
Results
We found that fire plays a key role in driving community structure and dynamics across community types, although with varying levels of intensity. Herbaceous species richness, abundance, and floristic quality index increased across all community types, while mean coefficient of conservatism decreased. Effects were stronger in drier sites. Community composition changed with successive burns, resulting in several indicator species for post burn treatments. The density of midstory trees declined across community types with repeated fire. The number of burns significantly affected overstory tree density overall, but overstory tree density only declined in dry woodlands and glades and not in dry mesic woodlands.
Conclusions
Our results suggest that landscape fire can shape plant community structure and dynamics. Specifically, these findings show that fire effects vary among community types, and suggest that land managers should consider landscape heterogeneity. Understanding repeated fire effects over several decades across multiple community types is critical to informing fire-driven woodland restoration across landscape scales.
Environmental Risk Assessment of Analgesics and Antibiotics in Effluents from Three Selected Hospitals in Kumasi Metropolis of Ghana
Authors: Nsafoah Emma Kofua , Gyeniaw Cindy Yaa , Sulemana Alhassan , Fei-Baffoe Bernard , Azanu David , Miezah Kodwo , Boateng Kofi Sekyere , Amprako Daniel Nimako , Hogarh Jonathan Nartey , Buabeng Kwame Ohene
Published: January 2024

Hospital effluents are the main source of pharmaceuticals like analgesics and antibiotics in the environment. This study seeks to determine the occurrence of commonly administered analgesics and antibiotics in hospital effluents and assess their environmental risks. Three replicates effluent samples from 3 hospitals (Kwame Nkrumah University of Science and Technology Hospital - KNUST, Kumasi South Hospital - KSH, and Komfo Anokye Teaching Hospital - KATH) within Kumasi were sampled and analyzed for occurrence of analgesics (caffeine, diclofenac, ibuprofen, and paracetamol); and antibiotics (amoxicillin, ciprofloxacin, and metronidazole). Samples were prepared for HPLC analysis by filtration and solid phase extraction. Apart from diclofenac and paracetamol detected at concentrations of 0.077–0.555 mg/L and 0.040–0.0440 mg/L respectively, all other pharmaceuticals were below detection levels in KNUST effluent samples. Caffeine (0.060–0.085 mg/L); diclofenac (0.055–0.380 mg/L); paracetamol (0.266–0.510 mg/L); ciprofloxacin (0.044–0.045 mg/L) and metronidazole (0.018–0.042 mg/L) were detected in KSH effluent samples; whilst ibuprofen and amoxicillin were below detection levels. In KATH effluent samples, ciprofloxacin and paracetamol were found at concentrations of 0.029–0.1142 mg/L and 0.074–0.232 mg/L respectively, and the rest were below detection levels. With the exception of the risk quotient (RQ) for ciprofloxacin showing high toxicity for exposure to algae and low toxicity exposure to daphnids and fish, the RQs for all other pharmaceuticals showed low toxicity exposure to algae, daphnids and fish. Pharmaceuticals in hospital effluents pose risk to aquatic life and human health with its associated socio-economic consequences. Thus, hospital effluents must be treated before discharge to avoid or reduce such negative effects.
Clinical Manifestations and Molecular Identification of Giardia duodenalis in Pediatric Cancer Patients in Shiraz, Southwestern Iran
Authors: Mahdavi Farzad , Mohammadi Mohammad Reza , Shamsi Laya , Asghari Ali , Shahabi Saeed , Motazedian Mohammad Hossein
Published: January 2024

Purpose
Understanding the prevalence of intestinal parasitic infections in the general population is crucial, especially in individuals with cancer. This study aimed to investigate the clinical and molecular characteristics of Giardia duodenalis (G. duodenalis) infection and identify potential risk factors in children and teenagers with malignancies in Shiraz, southwestern Iran.
Methods
200 fresh fecal samples were collected from children and adolescents suffering from 32 different cancer types at Amir, Nemazee, and Saadi hospitals affiliated with Shiraz University of Medical Sciences between October 2021 to May 2023. Direct microscopy using saline and iodine wet mount was conducted, and all fecal samples were rechecked by SSU-PCR. Subsequently, a DNA fragment from the tpi gene was amplified on SSU-PCR positive samples for sequencing and assemblage identification.
Results
Our study found a 4% (8/200) prevalence of G. duodenalis using microscopy and PCR. The molecular findings were consistent with the microscopic results. All eight positive samples with SSU-rRNA gene were also detected as positive with tpi gene and were correctly sequenced. Among the examined cancer patients, two assemblages were identified: A [sub-assemblage AI (2/8, 25%) and sub-assemblage AII (3/8, 37.5%)] and B [sub-assemblage BIV (3/8, 37.5%)]. Notably, patients were more vulnerable to G. duodenalis infection after receiving at least 8 treatment episodes (P < 0.05) and displaying gastrointestinal symptoms (P > 0.05). The demographic characteristics of cancer patients with Giardia infection and the statistical conclusions were separately detailed.
Conclusions
The small sample size and low prevalence rate in this study hindered precise epidemiological conclusions. Nonetheless, the results suggest that G. duodenalis infection among cancer patients in Shiraz city originates from humans, without any specific animal groups (C-H) involved. Additional molecular-based analyses are required to verify and build upon these findings.
Barriers and Facilitators to Uptake and Persistence on PrEP among Key Populations in Southern Province, Zambia: A Thematic Analysis
Authors: Stoebenau Kirsten , Muchanga Godfrey , Ahmad Sacha St-Onge , Bwalya Chiti , Mwale Mwangala , Toussaint Samara , Maambo Choolwe , Peters Carson J. , Baumhart Caitlin , Mwango Linah K. , Lavoie Marie-Claude , Claassen Cassidy W.
Published: January 2024

Background: Especially in high HV prevalence contexts, such as Zambia, effective biomedical prevention tools are needed for priority populations (PPs), including key populations (KPs), who are at higher risk. HIV pre-exposure prophylaxis (PrEP) has been scaled up nationally in Zambia, but little is known about barriers to PrEP use among specific PPs to date.
Methods: To understand barriers and facilitators to PrEP use in Zambia, we conducted a qualitative case study of PrEP services to PPs including sero-discordant couples (SDCs), female sex workers (FSWs), and men who have sex with men (MSM) in Livingstone. The study conducted in 2021 included in-depth interviews (n=43) guided by the socio-ecological model, and focus group discussions (n=4) with clinic and community-based providers and PrEP-eligible clients including users and non-users across PP groups. We used thematic analysis to analyze data using codes derived both deductively and inductively.
Results: We found multilevel barriers and facilitators to PrEP use. Cross-cutting barriers shared across PP groups included anticipated stigma resulting from PrEP being mistaken for antiretroviral drugs used to treat HIV and concerns about side-effects based on both misinformation and experience. PrEP stigma in this setting differed from studies in other regions; for example, there was little concern about PrEP being associated with promiscuity. The fear of being mislabeled as having HIV was of greatest concern for FSWs. Facilitators to PrEP use primarily included the importance of confidential, KP-sensitive services, and the role of informed, supportive family, friends, and peers. Participants across all PP groups urged expanded education efforts to increase awareness of PrEP within the general population toward mitigating concerns of being mislabeled as living with HIV.
Conclusion: To our knowledge, this is the first qualitative study of the PrEP cascade among PPs in Zambia. This study provides important explanation for the low rates of PrEP continuation found in earlier demonstration trials among KPs in Zambia. The study also offers recommendations for programming efforts going forward such as inclusive PrEP awareness campaigns, expanded KP sensitivity training, and related efforts to thwart PrEP stigma while expanding access.
Converter slag causes gradual collapse of chlamydospore of the rice false smut fungus and suppresses hyphal invasion into rice roots
Authors: Uchihashi Kaichi , Mitsunaga Takayuki , Ashizawa Taketo
Published: January 2024

The rice false smut disease has become a serious threat to rice production. Chlamydospores are the primary durable inoculum for this disease in paddy soil. Recently, mixing converter slag into paddy soil has been shown to decrease the occurrence of the disease; however, the mechanism underlying this suppression is unknown. To confirm the disease suppression, firstly we conducted the converter slag application test (3t/ha) in a paddy field. Next, we investigated the effects of converter slag-added solution (CSS), neutralized CSS (NCSS), and converter slag-added soil extract (CSSE), which corresponds to 3t/ha application of the converter slag in a paddy field, on chlamydospore morphology and germination, as well as the effect of CSSE on hyphal invasion of rice roots by germinated chlamydospores. The field test showed 75.6% suppression of the disease occurrence. Moreover, in the CSS test, the normal chlamydospores rapidly became transparent and gradually collapsed. In contrast, NCSS slowed chlamydospore collapse. The abnormal germination percentages in CSS were higher than those in NCSS. The percentages of transparent, collapsed, and normally germinated chlamydospores obtained in CSSE were intermediate between those obtained in CSS and NCSS. This suppression may have been due to the soil buffering effect. Furthermore, hyphal invasion by germinated chlamydospores into rice roots in CSSE was suppressed compared to that in control. These results suggest a gradual collapse caused by the cation may be suppressed by the anion, and subsequent infection of the rice roots may be inactivated. These mechanisms may be contributed to the disease suppression in fields.
Dual-targeting tigecycline nanoparticles for treating intracranial infections caused by multidrug-resistant Acinetobacter baumannii
Authors: Lan Xing , Qin Shugang , Liu Huan , Guo Mengran , Zhang Yupei , Jin Xinyang , Duan Xing , Sun Min , Liu Zhenjun , Wang Wenyan , Zheng Qian , Liao Xuelian , Chen Jinpeng , Kang Yan , Xie Yongmei , Song xiangrong
Published: January 2024

Multidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) is a formidable pathogen responsible for severe intracranial infections post-craniotomy, exhibiting a mortality rate as high as 71%. Tigecycline (TGC), a broad-spectrum antibiotic, emerged as a potential therapeutic agent for MDR A. baumanniiinfections. Nonetheless, its clinical application was hindered by a short in vivo half-life and limited permeability through the blood-brain barrier (BBB). In this study, we developed a novel nanocarrier, integrating a dual-targeting peptide Aβ11 and Tween 80 modification (Aβ11/T80@CSs), specifically designed to enhance TGC delivery to the brain for treating A. baumannii-induced intracranial infections. Our findings demonstrated that Aβ11/T80@CSs nanocarriers successfully traversed the BBB and effectively delivered TGC into the cerebrospinal fluid (CSF), leading to a significant therapeutic response in a model of MDR A. baumannii intracranial infection. This study offers initial evidence and a platform for the application of brain-targeted nanocarrier delivery systems, showcasing their potential in administering water-soluble anti-infection drugs for intracranial infection treatments, and suggesting promising avenues for clinical translation.
Optimization of Surface Roughness for Titanium Alloy Based on Multi- strategy Fusion Snake Algorithm
Authors: Zhao Guochao , Li Nanqi Q. , Zhao Yang , Wang Hui
Published: January 2024

Titanium alloy has the characteristics of low thermal conductivity, small elastic modulus, and serious work hardening, which makes it difficult to predict the surface quality after high-speed milling. Surface quality is known to significantly impact the wear resistance, fatigue strength, and corrosion resistance of parts. To improve the service performance of titanium alloy parts, it is of great significance to optimize the milling parameters based on the improvement of surface quality. Therefore, this paper proposes a milling parameter optimization method based on the snake algorithm based on multi-strategy fusion. The surface roughness was used as the optimization goal to optimize the parameters. Firstly, the response surface method was used to establish a prediction model of titanium alloy milling surface roughness to realize the prediction of surface roughness and make it continuous. Then, the snake algorithm with multi-strategy fusion was proposed, which initialized the population based on the orthogonal matrix initialization strategy, so that the population individuals were more evenly distributed in space, increased the diversity of the population, improved the model of food quantity and temperature in the algorithm, optimized the change mechanism of food quantity and temperature in the original algorithm into a dynamic adaptive mechanism, accelerated the convergence speed, used the joint reverse strategy to select and generate individuals with higher fitness, and strengthened the ability of the algorithm to escape the local optimal solution. Experimental results on five benchmarks with multiple comparative optimization algorithms show that the MSSO algorithm has faster convergence speed and higher convergence accuracy. Finally, the multi-strategy snake algorithm was used to optimize the optimization objective equation, and the milling parameter experiment shows that the surface roughness of Ti64 is increased by 55.7 percent compared with that before optimization, and the surface roughness of the specimen optimized by the multi-strategy fusion snake algorithm is significantly reduced, the surface toolpath row spacing is reduced, and the average height of the texture is reduced. This method can reduce the optimization time and ensure better optimization results than the classical optimization algorithm.
Predictive Role of Depressive Symptoms on Frailty and its Components in Chinese Middle-Aged and Older Adults: a Longitudinal Analysis
Authors: Sun Yuanhao , Li Xiangdong , Liu Haiyang , Li Yuqing , Gui Jiaofeng , Zhang Xiaoyun , Li Xiaoping , Sun Lu , Wang Congzhi , Li Jing , Liu Mingming , Zhang Dongmei , Gao Jingyi , Kang Xuefeng , Lei Yunxiao , Zhang Lin , Yuan Ting
Published: January 2024

Background
To investigate the cross-sectional and longitudinal associations between depressive symptoms and the prevalence of frailty and its components in a nationally representative sample of middle-aged and older Chinese adults.
Method
The China Health and Retirement Longitudinal Study (CHARLS) provided data on 17,104 adults aged ≥ 45 years. Every two years, face-to-face, computer-aided personal interviews (CAPI), and structured questionnaires were used to follow up with the respondents. The Chinese version of the Center for Epidemiologic Studies-Depression Scale (CES-D) was used to evaluate depressive symptoms, and the Fried criteria were used to measure frailty. The odds ratio (OR) and 95% confidence interval (CI) for the cross-sectional connections among depressive symptoms and frailty and its components in the individuals at baseline were analyzed using logistic regression. A Cox proportional hazards analysis was performed using the hazard ratio (HR) and 95% confidence interval for the prospective connection between baseline depressive symptoms and frailty and its component in the participants without frailty at baseline.
Results
At baseline, 11.62% of participants had frailty, and 57.92% had depressive symptoms. In the cross-sectional analysis, depressive symptoms (OR = 5.222, 95%CI 3.665–7.442) were associated with frailty. In the longitudinal analysis, after adjusting for the full set of covariates among participants free of baseline frailty, depressive symptoms were significantly associated with incident frailty during the short term [HR = 2.193 (1.324–3.631)] and the long term [HR = 1.926 (1.021–3.632)]. Meanwhile, depressive symptoms were associated with an increased risk of weakness [HR = 1.990 (1.250–3.166)], slowness [HR = 1.395 (1.044–1.865)], and exhaustion [HR = 2.827 (2.150–3.719)] onset during the short-term. Depressive symptoms were associated with an increased risk of exhaustion [HR = 2.869 (2.004–4.109)] onset during the long-term.
Conclusion
Among middle-aged and older adults, depressive symptoms could predict frailty during 2 years of follow-up and 4 years of follow-up. When considering potential confounding factors, depressive symptoms were considered a predictor of weakness, slowness, and exhaustion. Interventions aimed at preventing depressive symptoms may be beneficial in reducing frailty and its components.
Quantum transport for gate length scaling limit of Si NWFETs based on calibrated k·p Hamiltonian parameters
Authors: Wu Zhenhua , Zhan Guohui , Zhu Tongshuai , Yao Jiaxin , Luo Kun , Zhang Shengli , Yin Huaxiang
Published: January 2024

We present a comprehensive investigation of quantum transport in silicon nanowire field-effect transistors (Si NWFETs) at the scaling limit. The Si bulk $\bm{k}\cdot\bm{p}$ Hamiltonian parameters are rendered invalid at smaller scales due to pronounced quantum confinement effects. Consequently, nanowire $\bm{k}\cdot\bm{p}$ Hamiltonian parameters are meticulously calibrated using first-principle HSE06 band structures through the fast least square method. Based on the Non-Equilibrium Green's functon(NEGF) formalism, we systematically analyze the performance limits of \textrm{Si} gate-all-around NWFETs under varying gate lengths. With diminishing gate lengths, quantum tunneling from source to drain intensifies, leading to a degradation in subthreshold swing. Our findings reveal that the gate length scaling limit for N-type devices surpasses that of P-type devices, and distinct gate scaling limits are elucidated for varying cross-sectional sizes, for instance, the ultimate scaling limit of a 4 nm $\times$ 4 nm cross-section Si nanowires is approximately 10 nm.
Electric-field-induced crystallization of Hf0.5Zr0.5O2 thin film based on phase-field modeling
Authors: Huang Houbing , Liu Zhaobo , Shi Xiaoming , Wang Jing
Published: January 2024

Ferroelectricity in crystalline hafnium oxide has attracted considerable attention because of its potential application for memory devices. A recent breakthrough involves electric-field-induced crystallization, allowing HfO2-based materials to avoid high-temperature crystallization, which is unexpected in the back-end-of-line process. However, due to the lack of clarity in understanding the mechanisms during the crystallization process, we aim to employ theoretical methods for simulation, to guide experimental endeavors. In this work, we extended our phase-field model by coupling the crystallization model and time-dependent Ginzburg-Landau equation to analyze the crystalline properties and the polarization evolution of Hf0.5Zr0.5O2 thin film under applying an electric field periodic pulse. Through this approach, we found a wake-up effect during the process of crystallization and a transformation from orthorhombic nano-domains to the stripe domain. Furthermore, we have proposed an innovative artificial neural synapses concept based on the continuous polarization variation under applied electric field pulses. Our research lays the theoretical groundwork for the advancement of electric-field-induced crystallization in the hafnium oxide system.
AAGCN: A Graph Convolutional Neural Network with Adaptive Feature and Topology Learning
Authors: Wang Bin , Cai Bodong , Sheng Jinfang , Jiao Wenzhe
Published: January 2024

In recent years, there has been a growing prevalence of deep learning in various domains, owing to advancements in information technology and computing power. Graph neural network methods within deep learning have shown remarkable capabilities in processing graph-structured data, such as social networks and traffic networks. As a result, they have garnered significant attention from researchers.However, real-world data often face challenges like data sparsity and missing labels, which can hinder the performance and generalization ability of graph convolutional neural networks. To overcome these challenges, our research aims to effectively extract the hidden features and topological information of graph convolutional neural networks. We propose an innovative model called Adaptive Feature and Topology Graph Convolutional Neural Network (AAGCN). By incorporating an adaptive layer, our model preprocesses the data and integrates the hidden features and topological information with the original data's features and structure. These fused features are then utilized in the convolutional layer for training, significantly enhancing the expressive power of graph convolutional neural networks.To evaluate the effectiveness of the adaptive layer in the AAGCN model, we conducted node classification experiments on real datasets. The results validate its ability to address data sparsity and improve the classification performance of graph convolutional neural networks.In conclusion, our research primarily focuses on addressing data sparsity and missing labels in graph convolutional neural networks. The proposed AAGCN model, which incorporates an adaptive layer, effectively extracts hidden features and topological information, thereby enhancing the expressive power and classification performance of these networks.
Some Selected Secondary School Students Perception of the Quality of PGDE Teachers Trained By National Teachers Institute
Authors: Ogbu J.C. , Ganou Morino
Published: January 2024

This study samples the Perception Of Secondary School Students on the quality of PGDE Teachers produced through National Teachers Institute (NTI) of Nigeria program. The study was guided by four hypothesis and three research questions. Stratified random sampling technique was adopted in selecting a sample of 100 Secondary School Students from National Mathematical Centre International Model Science Academy and Government Secondary School Hajj camp. Questionaire containing sixteen items was used to elicit information. The data collected was analysed. The findings were PGDE Teachers produced through NTI program are competent in the general studies aspect of education, competent in their area of specialisation and in the professional aspect of teacher education. Some gray areas were identified in the general studies aspect of education and recommendations were made on how to improve NTI program generally.
Exploring the relationship between parental psychological control and children’s social behavior: A moderated mediation model
Authors: Liu Qian , Wang Shuqiong , Wang Li
Published: January 2024

This study investigates the relationship between parental psychological control and children’s social behavior, as well as the mediating role of parent-child conflict and the moderating effect of gender in 676 parents of young children in Shandong Province, China. The results show that (1) parental psychological control is negatively correlated with children’s prosocial behavior and positively correlated with children’s problem behavior; (2) parental psychological control significantly negatively predicts children’s prosocial behavior through parent-child conflict; and (3) parental psychological control can predict children’s problem behavior directly or positively through parent-child conflict. (4) The first half of the mediating effect of parental psychological control → parent-child conflict → children’s social behavior is moderated by gender. The moderating effect reaches a significant level in both boys and girls, and the effect is more prominent in girls than in boys.
Optimizing an electromagnetic wave absorber for Bi-anisotropic metasurfaces based on Toroidal modes
Authors: Aghdasinia Sina , Allahverdizade Hosein , Afkari Ehsan , Ahmadpour behrouz , bemani mohammad
Published: January 2024

The design and optimization of an electromagnetic wave absorber for far-field wireless power transmission (WPT) is the subject of this research study. The goal of the research is to effectively absorb energy from ambient RF electromagnetic waves without the usage of a ground plane by employing metasurfaces with chiral components.By integrating trioidal moments into the design theory, the objective is to create a metasurface that functions in two frequency bands and produces high-quality resonance. The study also explores the dual non-homogeneity property of structures, polarization tensor coefficients, and the electromagnetic response of non-homogeneous metasurfaces. Based on the relative orientation of induced fields and moments, it delves deeper into the two basic possibilities for dual non-homogeneous elements. The development of chiral metasurfaces and the notion of electromagnetic chirality and its implications for polarization properties are introduced