bluuebunny/crossref_metadata_2025 huggingface dataset:
Coda
Authors: Halliday Aria S.
Published: October 2022

From the haircare industry and hip-hop to children’s imaginative play with Mattel’s dolls and Disney’s princesses, Buy Black calls us to consider how Black women cultural producers play a pivotal role in US and global populations’ consumption of Black femininity. As designers, actors, and icons, they fomented Black women’s buying power and the need for corporations and politicians to incorporate Black women’s perspectives in their products and ads. The coda, “The Stakes of Twenty-first-Century Black Creativity,” challenges the usefulness of Black women’s embodied objectification in Kasi Lemmons’s Harriet (2019). Recalling debates at the turn of the century over Black doll representation, it argues Black women cultural producers must be attentive to diversity within Black women’s experiences to continue to connect with Black women consumers.
Polarization and the Politics of Resentment
Authors: Simpson Dick
Published: October 2022

Political polarization is widespread in the country. There is resentment in the electorate and a widening gap between the political parties. We need to manage these conflicts and create a rebirth of freedom. In Chicago this polarization is partly based on racial and ideological divisions. In the Harold Washington era in the 1980s, the Council Wars clearly reflected tensions in the electorate. The 50-person city council was split 29-21. Government was gridlocked, as it has been nationally in the 21st century because of partisanship and an unwillingness to compromise. The policy differences today between Republicans and Democrats and between Trump supporters and opponents dwarf other differences. There is a split between those who live in cities, suburbs, or rural areas. These divisions are also about who we are as a people. The polarization, resentment, and gridlock produce dissatisfaction with our democracy and must be overcome for there to be a rebirth.
A Monument to Negro Enterprise
Authors: West E. James
Published: October 2022

This chapter begins with the Defender’s relocation to an impressive new headquarters on Indiana Avenue during the early 1920s, something that consolidated its status as the nation’s most influential Black periodical. The Defender’s new offices formed part of a Black “newspaper row” on the South Side that reached its apex during the 1920s. As a new wave of Black periodicals, including the Chicago Whip and the Chicago Bee, emerged after World War I, they turned to the built environment as a way to challenge the Defender’s position as the “dean” of Chicago’s Black press. At the same time, Chicago’s Black periodicals pushed back against racist descriptors of the “Black Belt” through the creation of new Black urban geographies such as “Defenderland” and “Bronzeville.”
A Comprehensive Review on Beyşehir Tarhana, A Turkish Traditional Food
Authors: Başlar Mehmet , Özçelik Gökçe Nur , Çalışkan Hacer
Published: October 2022

Tarhana, hold an important place in Turkish culture, and has a gastronomic value that stands out in different geographies, especially in Turkey, with its diversity. Although many comprehensive studies exist in the literature regarding the types of tarhana, very limited literature information is available on Beyşehir tarhana, which has many unique features and is mentioned in some historical events. The present study aims to create the necessary background in scientifically defining Beyşehir tarhana in a better way and enabling it to be the subject of various research. In the frame of this aim, a comprehensive literature search was performed on Beyşehir tarhana and the information was compiled using a systematic method. In the study, firstly Beyşehir tarhana was examined in comparison with other tarhana types, and its characteristic features were discussed in a conceptual framework. Second, the production steps of Beyşehir tarhana, which has a unique and simple making process with the use of yogurt, yarma wheat and salt, was explained in detail, and consumption habits in the region were revealed. And lastly, the nutritional values of Beyşehir tarhana were evaluated based on the quantitative data present in the literature. Beyşehir tarhana has a remarkable feature to be able to be considered as the ancestor of other tarhanas due to the ingredients used in its production and its name being referred in some historical events. In conclusion, it can be stated that multidimensional and more comprehensive quantitative and qualitative scientific studies should be conducted on Beyşehir tarhana.
Tourist diners demographic characteristics and neophobic tendencies to local cuisine in Botswana
Authors: Chatibura Delly Mahachi
Published: October 2022

An attempt to explore the influence of demographic characteristics on the food neophobic tendencies of diners is undertaken. Using independent sample t tests and analysis of variance, the influence of age, gender, nationality and the level of education, on the perceived avoidance of traditional Setswana cuisine consumption was investigated. Two hundred and forty nine diners from 47 restaurant facilities in Gaborone formed the sample. Key findings from the study reveal that, on average, (though statistically insignificant), male respondents experienced higher levels of Setswana cuisine neophobia than female diners. Furthermore, the paper noted that diners above 50 years of age reported significantly higher levels of neophobia than lower age groups. The findings also indicate to some extent that diners may not necessarily be compelled to taste local cuisine based on familiarity. The paper concludes by suggesting the need for more research on the relationship between familiarity and shared cultural contexts, with food neophobia.
تفعيل مقاصد الشريعة في المجال السياسي
Authors: العوا محمد سليم
Published: October 2022

يضم هذا الكتاب بين دفتيه ثلاثة عشر بحثًا القيت في ندوة علمية، وهي بحوث رصينة عالجت موضوعات نظرية وأخرى تطبيقية، كما أجرت مقارَبات مقاصدية ذات علاقة بموضوع الندوة، وأجابت عن إشكاليات واقعية مطروحة، وناقشت جدليات مثارة في الواقع السياسي العربي الحالي. وقد ناقش بعض بحوث الدورة إشكالية الدولة المدنية ذات المرجعية الإسلامية، والتطبيق المتدرّج للشريعة، وضرورة تأسيس علم مقاصد سياسي خاص وتفعيله مع الضبط الدقيق للأولويات عند تزاحم المطالب التي يفرضها الواقع. وبلور بعضها تأسيسًا مقاصديًّا لمسألة «التعدّدية وتداول السلطة». وقدّم بعضها تصورًا لعلاقة البرلمانات بالإجماع. واستعرض بعض البحوث مشروعية المشاركة السياسية، وحق التنظيم والانتخابات، مع التأكيد على أن الانتظام في الأحزاب والجمعيات، من أفضل السبل وأوكدها لتحقيق مقصد الحرية وإنجاز البعث الحضاري الإسلامي. ودرس بعضها بعمق الأهمية النظرية والعملية لـ«فقه السياسة الشرعية» من منظور النصوص والمقاصد الشرعية، مؤصلًا للسياسة الشرعية، ومرجعية مقاصد الشريعة للسياسة الشرعية، متناولًا إشكالية «فصل الدين عن الدولة والمجتمع»، مع تنزيل فقه السياسة الشرعية على «الانتخابات». واستقصى بعضها دراسة المجتمع المدني ومقاصده، وجدلية استيعابه واستبعاده، والعوائق التي تحدُّ من فعاليته في قيامه بوظيفة الإصلاح السياسي والتحول الديمقراطي في البلدان العربية، وقدم طروحات نظرية حول سياسات المجتمع المدني ومقاصده في النظم المختلفة. وتناول بعض بحوثها مقاصد الشريعة في قوانين العمل وحقوق العمال، وتعميق الرقابة الذاتية لدى المتعاملين. واستعرض بعضها تقارير حقوق الإنسان في ضوء نظرية المقاصد ،من خلال مقارنة بعض مواد «الإعلان العالمي لحقوق الإنسان 1948»، و«اتفاقية تحريم السُّخرة 1957».
LE BAMLANIVIMAB DANS LE TRAITEMENT DE LA COVID-19 LEGERE A MODEREE : UNE APPROCHE FACTUELLE
Authors: POUCHAIN D , LE ROUX G , TUDREJ B , GOCKO X , BOUSSAGEON R
Published: October 2022

Le 24 février 2021, l’Agence nationale de sécurité du médicament et des produits de santé (ANSM) a octroyé une autorisation temporaire d’utilisation de cohorte au bamlanivimab pour traiter les patients atteints d’une Covid-19 légère à modérée non hospitalisés, mais considérés comme à haut risque de développer une forme sévère. Le lendemain, la Direction générale de la santé (DGS) a adressé à tous les médecins ambulatoires un message urgent pour qu’ils repèrent ces patients, documentent la Covid-19 avec un test RT-PCR, et les adressent directement à un hôpital dédié ou via le centre 15, le tout en moins de 5 jours après les premiers symptômes. La lecture des essais randomisés versus placebo publiés dans de prestigieuses revues internationales montre que 700 mg de bamlanivimab en une perfusion unique (posologie de l’ATUc) administrée à l’hôpital n’a aucune efficacité sur la charge virale à 11 jours et encore moins sur la survenue de formes sévères chez des patients ambulatoires non graves dont la majorité guérit spontanément. Devant ce constat et l’absence d’information scientifique argumentant l’injonction de la DGS, il est licite de s’interroger sur cette démarche qui discrédite la méthode scientifique, accrédite le « deux poids, deux mesures » et soulève la question éthique de la place réservée au libre arbitre éclairé et argumenté des médecins et des patients.
SARS-CoV-2 Infection in Filipino Children: An Interim Report from the SALVACION Registry
Authors: Rivera Abigail , Pantig Francesca Mae , Maramba-Lazarte Cecilia , Dy-Co Arlene , Rosales Venus Oliva , Sarmiento Raymond Francis , Aguelo Allyne , Delos Santos-Jamora Mary Crist , Luna Imelda , Padua Jay Ron , Pasco Cleo Anna Marie , Tan-Figueras Anna Soleil Cheshia , Torres Pia Catrina
Published: October 2022

Background: The COVID-19 pandemic continues to afflict nations worldwide. The Philippines is no exception which has recorded more than 3 million cases as of December 2021 with children comprising 12% of total cases. Since the start of the pandemic, the Pediatric Infectious Disease Society of the Philippines (PIDSP) has been collecting data nationwide, through an online pediatric COVID-19 registry (SALVACION registry), to provide a better understanding of COVID-19 in children in the local setting. Methods: This was an ambispective cohort study of pediatric COVID-19 cases in the Philippines reported from March 2020 to December 2021. Data on clinical features, laboratory findings, disease severity, and treatment outcomes were voluntarily reported by physicians across the country. This study was approved by the Department of Health Single Joint Research Ethics Board. Results: As of December 30, 2021, there were 2,127 cases reported in the registry, with a median age of 5 years (interquartile range: 1-13 years) and mostly mild (41.9%) or moderate (24.5%) in severity. The top symptoms reported were fever (57.9%), cough (42.7%), coryza/colds (29.4%), anorexia (25.2%), and difficulty of breathing (23.1%). The most common comorbidities were hematologic-oncologic diseases (7.4%), neurologic diseases (7.0%) and surgical conditions (4.4%), while the most common coinfections were sepsis (6.3%), dengue fever (4.8%) and healthcare-associated pneumonia (2.1%). Significantly higher median CRP, procalcitonin, D-dimer, ferritin, transaminases and lactate dehydrogenase were seen among severe/critical cases compared to non-severe cases. There was a high frequency of antibiotic use (58%). Most cases recovered, although 172 deaths were reported with an 8.6% case fatality rate. The most common comorbidities in those who died were neurologic (15.7%), cardiac (12.8%) and hematologic (11.6%) diseases. Conclusion: Children across all age groups are susceptible to COVID-19 and most cases are mild or moderate in severity. Among severe and critical cases, the most common comorbidities were neurologic, hematologic-oncologic and cardiac diseases. Most patients recovered with supportive management.
EFEKTIFITAS PEMBELAJARAN PADA PELATIHAN JARAK JAUH ILMU PENGETAHUAN ALAM MADRASAH TSANAWIYAH ANGKATAN 2 DENGAN MENGUNAKAN MODEL ADDIE
Authors: Nurdin Saeful
Published: October 2022

Penelitian ini bertujuan untuk mengetahui efektifitas pembelajaran pada pelatihan jarak jauh guru IPA Madrasah Tsanawiyah Angkatan 2. Metode yang digunakan metode kuantitatif deskriftif dan jenis penelitian pengembangan. Penelitian ini diadaptasi dari  Pengembangan model ADDIE yang tiga tahap 1. Pemodelan, terdiri dari analisis, dan desain pembelajaran; tahap 2. Pengembangan, terdiri dari pengembangan konten dan pengembangan produksi video pembelajaran; dan tahap 3. Implementasi, terdiri dari implementasi materi esensial dan media lab virtual serta evaluasi.. Angkatan 2 yang telah lulus seleksi sebanyak 38 orang. Efektifitas pemahaman kognitif terhadap konten pelatihan jarak jauh IPA MTs Angkatan 2 dengan nilai tertinggi 100 dan tertendah 57,50 serta rata-rata kelas 83,16. Pengembangan Pelatihan PJJ IPA MTs Angkatan 2 dengan kursil yang baru dapat tercapai dengan efektif melalui model pengembangan ADDIE
EVALUASI KOMPETENSI PEDAGOGIK GURU PPKn PASCA-PELATIHAN DARING DI PPPPTK PKn DAN IPS
Authors: Malady Gatot
Published: October 2022

Penelitian ini bertujuan untuk melihat perubahan perilaku guru pada aspek kompetensi pedagogik setelah mengikuti pelatihan daring di PPPPTK PKn dan IPS (Pusat Pengembangan Pemberdayaan Pendidik dan Tenaga Kependidikan, Pendidikan Kewarganegaraan dan Ilmu Pengetahuan Sosial). Evaluasi kompetensi pedagogik tersebut mencakup pemahaman guru terhadap murid, merencanakan dan melaksanakan pembelajaran, memanfaatkan media pembelajaran, memanfaatkan teknologi informasi dan komunikasi dalam pembelajaran, serta melakukan evaluasi hasil belajar. Penelitian ini termasuk dalam penelitian evaluasi dengan pendekatan kuantitatif. Model evaluasi yang digunakan pada penelitian ini adalah model evaluasi Kirkpatrick level-3 yaitu behavior (perubahan perilaku). Penelitian dilakukan dengan memberikan kuesioner instrumen kepada semua guru PPKn alumni pelatihan daring di PPPPTK PKn dan IPS sejumlah 189 orang. Hasil penelitian menunjukkan bahwa secara umum kompetensi pedagogik guru setelah mengikuti pelatihan daring dinyatakan baik dengan nilai rata-rata 88,49. Secara terperinci nilai rata-rata untuk setiap komponen adalah sebagai berikut: 89,88 untuk pemahaman terhadap murid; 89,15 untuk perencanaan dan pelaksanaan pembelajaran; 88,77 untuk pemanfaatan media pembelajaran; 89,06 untuk pemanfaatan teknologi informasi dan komunikasi dalam pembelajaran, serta 85,61 untuk evaluasi hasil belajar.
PEMANFAATAN METODE CREATIF PLOBLEM SOLVING DALAM MENINDAKLANJUTI HASIL EVALUASI PENYELENGGARAAN PENDIDIKAN DAN PELATIHAN KEARSIPAN
Authors: Mulyaningrum Vicihayu Dyah
Published: October 2022

Artikel ini mendeskripsikan tentang pemanfaatan metode creatif problem solving dalam menindaklanjuti hasil evaluasi penyelenggaraan pendidikan dan pelatihan kearsipan. Penulisan artikel ini metode yang digunakan dalam proses pengumpulan data dalam penelitian adalah wawancara mendalam, observasi partisipatif dan studi dokumentasi. Tujuan penulisan artikel bertujuan mengetahui hasil pemanfaatan metode creatif problem solving dalam menindaklanjuti hasil evaluasi penyelenggaraan pendidikan dan pelatihan kearsipan. Berdasarkan hasil penelitian diketahui bahwa kepuasan peserta diklat terhadap penyelenggaraan diklat pada bulan Februari-Maret 2019 sebesar 79,20% berada pada kategori sedang mengalami kenaikan 3,10 % menjadi 82,30% di bulan April 2019 sehingga berada pada kategori memuaskan. Hal yang sama juga ditunjukkan pada bulan Mei 2019 yang mengalami kenaikan 5,90% menjadi 85,10% berada pada kategori memuaskan. Hal tersebut menunjukkan bahwa pemanfaatan metode creatif problem solving dalam menindaklanjuti hasil evaluasi penyelenggaraan pendidikan dan pelatihan kearsipan mampu menaikkan kepuasan peserta diklat.
PENERAPAN BINA DIRI DENGAN TEKNIK MODELLING UNTUK MENINGKATKAN PERILAKU ADAPTIF SISWA KELAS VIII C SEKOLAH LUAR BIASA YPPABK NGAWI
Authors: Setyowati Eny , Solekah Anisah Binti Solekah , Pratiwi Resa Andi
Published: October 2022

ABSTRACT This research is written to increase effectiveness tunagrahita learning activities in VIII C YPP ABK Ngawi can behave adaptive behavior and leave non adaptive. The kind of research used is case study, that is a discriptive and analysis a specified phenomenon social as individual or unit, group an intitution or community. The implementation of a development modelling to facilitate students in understanding and practice material provided by teacher making it the adaptive students behavior seen from the behavior changes and attitudes interact social students in all teachers or by part of his class, they didn’t even conduct behavior non adaptive as before.

Keywords : Self development, modelling technique, adaptive behavior
MENINGKATKAN KEMAMPUAN MENGHAFAL SURAT-SURAT PENDEK DENGAN METODE TALAQQI PADA USIA 5-6 TAHUN DI RA PERWANIDA KROMPOL BRINGIN
Authors: Prasetiyo Eko , Layli Aisyah
Published: October 2022

ABSTRACT Raudhatul Athfal (RA) is the level of Early Childhood Education in the formal pathway that organizes general and Islamic education programs. The purpose of this study is to try to find out how children can be happy with learning to memorize short letters so that children are able to memorize short letters properly and correctly. This study uses a qualitative approach with a qualitative descriptive type with a classroom action research approach, namely the data obtained in the form of written or spoken words from the results of observations and interviews / direct practice at the time of the study. The research sample amounted to 15 students, data collection techniques used observation, interviews, documentation and reflection techniques. Based on the results of the study, it was shown that increasing the ability to memorize using the talaqqi method at RA Perwanida Krompol in this study was successful in improving the memorization of short letters. It is proven by an increase in the ability to memorize short letters in children who initially did not achieve well, then after doing research using the talaqqi method many children reached the very good category.
ATENDIMENTOS EM SAÚDE NA PERSPECTIVA DE TRANSEXUAIS
Authors: Cohen Carla Ribeiro , De Tilio Rafael
Published: October 2022

Este artigo teve como objetivo compreender como transexuais significam os atendimentos em saúde, em um hospital público, na microrregião do Triângulo Mineiro. Nove transexuais foram entrevistados, e os conteúdos foram organizados em quatro categorias para análise temática (concepções sobre transexualidade; informações; percepções sobre atenção à saúde; concepções sobre direitos e preconceitos). Os principais resultados apontaram para: a compreensão da transexualidade como experiência identitária discordante com o corpo biológico; a busca por modificações corporais; as insuficiências e ausências de informações e organização para acesso, adesão e permanência naquele serviço de saúde; respeito ao nome social, apesar de pontuais discriminações por parte de alguns profissionais de saúde. A não consolidação das políticas de atenção básica de saúde (especialmente da integralidade) pode afastar e dificultar essa população de um direito que lhe é garantido, porém nem sempre observado.
Topic Coherence Metrics: How Sensitive Are They?
Authors: Campagnolo João Marcos , Duarte Denio , Dal Bianco Guillherme
Published: October 2022

Topic modeling approaches extract the most relevant sets of words (grouped into so-called topics) from a document collection. The extracted topics can be used for analyzing the latent semantic structure hiding in the collection. This task is intrinsically unsupervised (without information about the labels), so evaluating the quality of the discovered topics is challenging. To address that, different unsupervised metrics have been proposed, and some of them are close to human perception, e.g., coherence metrics. Moreover, metrics behave differently when facing noise (i.e., unrelated words) in the topics. This article presents an exploratory analysis to evaluate how state-of-the-art metrics are affected by perturbations in the topics. By perturbation, we mean that intruder words are synthetically inserted into the topics to measure the metrics’ ability to deal with noises. Our findings highlight the importance of overlooked choices in the metrics sensitiveness context. We show that some topic modeling metrics are highly sensitive to disturbing; others can handle noisy topics with minimal perturbation. As a result, we rank the chosen metrics by sensitiveness, and as the contribution, we believe that the results might be helpful for developers to evaluate the discovered topics better.
Lack of Supportive Systems for Parents of Children with Thalassemia: Forgotten Part of Health System
Authors: Heidari Haydeh , Ahmadi Ali
Published: October 2022

Background: Families of children with thalassemia may become exhausted due to the frequent hospitalizations of the child for blood injections and because of spending a great deal of time learning about and managing this disease. Objectives: The aim of this research was to explain supportive systems for parents of children with thalassemia. Methods: This study was done at Hajar hospital in Shahrekord in 2017. Content analysis was used. Ten samples consisting of 5 mothers, one grandmother, two fathers, and two nurses were selected purposely in this study. A semi-structured, face-to-face interview was used. Results: Based on data analysis, three categories of the need for supporters, lack of consultative services, and economic problems were obtained. Conclusions: Since thalassemia is a chronic disease, the parents of these children need support and consultative services throughout their life. It is necessary for authorities and healthcare planners to take measures in order to support parents of children with thalassemia (the forgotten part of the health system). The consultant-trained nurse has an important role in supporting these families.
Identificación de las contribuciones de las mipymes a la competitividad territorial: análisis de dos actividades económicas en Cauca, Colombia
Authors: Sánchez Tróchez Diana Ximena , Potes Ordoñez Laura Beatriz , De la Torre Solarte Gabriel , Rivera Martínez Wilfred Fabián
Published: October 2022

Objetivo: este artículo analiza las dinámicas empresariales de dos actividades económicas representativas de la economía nacional como lo son la manufactura y la construcción a fin de identificar la perspectiva empresarial y el análisis del entorno general, elementos relevantes en el tejido empresarial que inciden en las mediciones de competitividad.

Metodología: Para lograr este propósito se diseñó una metodología mixta que aplicó encuestas y entrevistas semiestructuradas a 146 empresas representativas de estos sectores en el departamento del Cauca, en el sur-occidente colombiano.

Resultados: entre los hallazgos de mayor relevancia se encuentran las variables que inciden en la perspectiva empresarial y los elementos del entorno en los que se desempeñan estas empresas como la fuente primaria de elementos, cuya gestión precisa de mayor atención por parte de agencias estatales y organizaciones de apoyo empresarial a fin de contribuir al mejoramiento de la competitividad en el ámbito territorial.

Limitaciones: se presentan dificultades en el trabajo de campo, debido a las exigentes medidas de bioseguridad de las organizaciones por la emergencia sanitaria del covid 19, extendiendo los tiempos de ejecución previstos inicialmente.

Implicaciones prácticas: el estudio es de utilidad en áreas de direccionamiento estratégico y gestión empresarial, promoviendo el fortalecimiento del tejido empresarial a partir de la formación de empresarios con una visión prospectiva según los requerimientos del contexto, siendo extrapolable incluso a otros sectores económicos.
De qué hablamos cuando hablamos de diseño
Authors: Lavernia Nacho
Published: October 2022

El diseño se está convirtiendo en el método que aplicar para buscar soluciones a lospequeños y grandes problemas económicos, empresariales, sociales omedioambientales, que un mundo en crisis profunda está provocando. De hecho, supráctica se está expandiendo y en los últimos tiempos han surgido especialidades comoel diseño de servicios, el diseño social, el diseño de experiencias o el design thinking.Esta dispersión del diseño hace difícil definirlo y pone en duda de qué hablamos cuandohablamos de diseño. El propósito de este artículo es compartir una definición del diseñobasada en tres características de la disciplina que parecen comunes también a estasnuevas especialidades: una actitud creativa; capacidad expresiva, y trabajar siempre enla relación entre los objetos y las personas. Tres cualidades que nos caracterizan y, a lavez, nos diferencian de otro tipo de profesionales como ingenieros o artistas.
Hook type tableaux and partition identities
Authors:   Research Institute for Symbolic Computation, Johannes Kepler University, Banerjee Koustav , Ghosh Dastidar Manosij ,   Technische Universität Wien
Published: October 2022

In this paper we exhibit the box-stacking principle (BSP) in conjunction with Young diagrams to prove generalizations of Stanley’s and Elder’s theorems without even the use of partition statistics in general. We primarily focus on to study Stanley’s theorem in color partition context.
Arithmetical functions associated with conjugate pairs of sets under regular convolutions
Authors:   Tampere University, Haukkanen Pentti
Published: October 2022

Two subsets P and Q of the set of positive integers is said to form a conjugate pair if each positive integer n possesses a unique factorization of the form n = ab, a ∈ P, b ∈ Q. In this paper we generalize conjugate pairs of sets to the setting of regular convolutions and study associated arithmetical functions. Particular attention is paid to arithmetical functions associated with k-free integers and k-th powers under regular convolution.
Pathogenic strains of Shewanella putrefaciens contain plasmids that are absent in the probiotic strain Pdp11
Authors: Domínguez-Maqueda Marta , Pérez-Gómez Olivia , Grande-Pérez Ana , Esteve Consuelo , Seoane Pedro , Tapia-Paniagua Silvana T. , Balebona Maria Carmen , Moriñigo Miguel Angel
Published: October 2022

Shewanella putrefaciens Pdp11 is a strain described as a probiotic for use in aquaculture. However, S. putrefaciens includes strains reported to be pathogenic or saprophytic to fish. Although the probiotic trait has been related to the presence of a group of genes in its genome, the existence of plasmids that could determine the probiotic or pathogenic character of this bacterium is unknown. In the present work, we searched for plasmids in several strains of S. putrefaciens that differ in their pathogenic and probiotic character. Under the different conditions tested, plasmids were only found in two of the five pathogenic strains, but not in the probiotic strain nor in the two saprophytic strains tested. Using a workflow integrating Sanger and Illumina reads, the complete consensus sequences of the plasmids were obtained. Plasmids differed in one ORF and encoded a putative replication initiator protein of the repB family, as well as proteins related to plasmid stability and a toxin-antitoxin system. Phylogenetic analysis showed some similarity to functional repB proteins of other Shewanella species. The implication of these plasmids in the probiotic or pathogenic nature of S. putrefaciens is discussed.
Contribution of Professional Teachers to the Local Economy of Cebu City, Philippines
Authors: Almaden Antoniette , Herbieto Jan Roel , Velasco Mila Mae
Published: October 2022

A yoga teacher deems professional when remuneration is generated from teaching and guiding students on the path of Yoga, including the practices of pranayama, meditation, and asana. This study intends to determine whether professional yoga teachers contribute an economic value in terms of employment and income tax to the local economy of Cebu. This study used the quantitative research method. About ten professional yoga teachers certified by Yoga Alliance, Vinyasa Yoga Academy, Mudra School, and World Peace Yoga School participated in the online survey. Economic evaluation tools such as break-even and cost- benefit analysis were applied to determine the cash flows generated between the investment (cost) incurred from acquiring the certification of a registered yoga teacher (RYT) and the earnings (benefit) generated from yoga classes conducted. It was discovered that a registered yoga teacher earns an average pay of Php165 or USD 2.9216 per hour per student derived from the 60/40 profit-sharing principle. Given the fixed cost of acquiring the RYT-200 certification and the estimated monthly earnings, part-time professional yoga teachers would need at least six months, and full-time would need at least two months to break even. The cost-benefit ratio indicates that the cash flows generated were viable since CBR >1; for each 1-peso value in the teacher’s training certification and equipment costs, 2.07 peso benefits for part-time and 6.70 pesos for full-time were generated. Therefore, professional yoga teachers were expected to create incremental economic value contributions to the local economy of Cebu.
Assessment of the Implemented Kapatid Mentor ME Program (KMME) of the Department of Trade and Industry (DTI) in Region VII, Philippines
Authors: Almaden Antoniette , Yu Bryll
Published: October 2022

The Kapatid Mentor ME (KMME) Program is a 10-module mentorship and coaching program initiative of the Department of Trade and Industry (DTI) and Philippine Center for Entrepreneurship (PCE) - Go Negosyo to help the country's Micro and Small Enterprises (MSEs). Since the COVID-19 pandemic started, the program was transitioned from face-to-face to an online learning platform. The study aimed to assess the implementation of the program from the period 2016 to 2021 to streamline the future direction and craft a more holistic initiative for MSEs. The study used a descriptive research design. An online questionnaire was administered to the 257 respondents clustered by Region VII provinces. There were advantages and disadvantages identified for both learning approaches used. The respondents considered the advantages of face-to-face learning as hands-on learning, easy networking, and a conducive learning environment. Also, the advantages of the online learning approach were accessibility of time and place, comfort, and abundant online resources. It was discovered that 74.75% of the mentee graduates had improved their business status after joining the program. To ensure sustainability and scaling up of MSEs, strengthening the monitoring phase and maximizing the enterprise development track tool are recommended to address the gap of the 25.25% non-improving mentee graduates through concrete and specific intervention schemes recommended.
Prevalence and causes of neonatal mortality in Brazil / Prevalência e causas da mortalidade neonatal no Brasil
Authors: Camara Paulista Marcilene , Silva de Azevedo Lays , Melo Emiliana Cristina , Rosseto de Oliveira Rosana
Published: October 2022

Objetivo: analisar a prevalência e causas da mortalidade neonatal no Brasil. Método: estudo transversal dos óbitos neonatais ocorridos de 2010 a 2019. Foram utilizados registros do Sistema de Informação sobre Nascidos Vivos e do Sistema de Informação sobre Mortalidade. As análises ocorreram por meio de frequências absolutas e relativas. Resultados: ao analisar a prevalência da mortalidade neonatal no Brasil, percebe-se grande diversificação no coeficiente nas diferentes regiões brasileiras. Embora houve redução no período, notam-se flutuações, com coeficientes maiores para região nordeste. A maior proporção dos óbitos ocorrem por causas perinatais, os quais, na grande maioria são evitáveis. Conclusão: o estudo permitiu observar que apesar dos avanços no atendimento pré-natal e ao recém nascido, ainda prevalecem coeficientes significativos de mortalidade neonatal, tendo como causas principais as perinatais e malformações congênitas. Por outro lado, os dados permitem sinalizar regiões com proporções elevadas, possibilitando um planejamento regional mais efetivo.
Anti-LGI1–Associated Myopathy in the Setting of Neuromuscular Hyperexcitability Syndrome
Authors: Anderyas Peter , Halliday Amy , Reardon Katrina
Published: October 2022

This case report describes a patient with anti–leucine-rich glioma-inactivated 1 (LGI1)–associated hyperexcitability syndrome associated with myopathy.
Association of Spike-Specific T Cells With Relative Protection From Subsequent SARS-CoV-2 Omicron Infection in Young Children
Authors: Dowell Alexander C. , Ireland Georgina , Zuo Jianmin , Moss Paul , Ladhani Shamez ,   sKIDs Investigation Team
Published: October 2022

This cohort study investigates the risk of SARS-CoV-2 reinfection among young children with and without spike-specific T-cell responses.
Metal‐Free Rapid Sulfonylation of para‐Quinone Methides and N‐Arylmaleimides with Sulfonyl Hydrazides via a Free‐Radical Pathway
Authors: Gairola Deepti , Peddinti Rama Krishna
Published: October 2022

Metal‐free oxidative sulfonylation strategy for the direct incorporation of sulfonyl units to access 3‐sulfonyl succinimides, diarylmethyl sulfones and diarylsulfones via a free‐radical pathway under aerobic conditions in aqueous media has been developed. Using easily accessible sulfonyl source, this methodology proceeds efficiently with a high degree of functional group compatibility under operationally simple reaction conditions. In this novel transformation with moderate to excellent yield, a green reaction system is established without the risk of metal contamination and inert atmosphere at room temperature. Mechanistic investigations revealed that sulfonyl radicals could be generated in situ from sulfonyl hydrazides in the presence of I2/TBHP under aerobic conditions.
Conversion of a AuI Fluorido Complex into an N‐Fluoroamido Derivative: N−F versus Au−N Reactivity
Authors: Rachor Simon G. , Ahrens Mike , Braun Thomas
Published: October 2022

The AuI complex [Au{N(F)SO2Ph}(SPhos)] (SPhos=dicyclohexyl(2′,6′‐dimethoxy[1,1′‐biphenyl]‐2‐yl)phosphane) (2) bearing a fluoroamido ligand has been synthesized by reaction of the fluorido complex [Au(F)(SPhos)] (1) with NFSI (NFSI=N‐fluorobenzenesulfonimide). A reaction with CO resulted in an unprecedented insertion into the N−F bond at 2. With the carbene precursor N2CH(CO2Et) N−F bond cleavage gave the Au−F bond insertion product [Au{CHF(CO2C2H5)}(SPhos)] (7). The presence of CNtBu led to Au−N cleavage at 2 and concomitant amide formation to give the cationic complex [Au(CNtBu)(SPhos)][N(F)SO2Ph)] (5), which reacted further to give FtBu as well as the cyanido complex [Au(CN)(SPhos)] (6). These results led to the development of a process for the amination of electrophilic organic substrates by transfer of the fluoroamido group NF(SO2Ph)−.
How people deal with …............................ outliers
Authors: Dannals Jennifer E. , Oppenheimer Daniel M.
Published: October 2022

People regularly make sense of distributions that are complicated by noise. How do individuals determine whether an outlying observation should be incorporated into one's understanding of the true distribution of the population or considered a fluke that ought to be disregarded? In a simple prediction task, we examine how individuals incorporate outliers and compare their behavior to various prescriptive models (e.g., averaging and tests of discordancy). We find that, on average, individuals do discount outlying values and that their outlier detection strategies approximate approaches that statisticians have recommended for Gaussian distributions, even when the observed distributions are not Gaussian. However, there are notable differences in treatment of outliers across individuals.
Enzyme Engineering Enables Inversion of Substrate Stereopreference of the Halogenase WelO5*
Authors: Voss Moritz , Hüppi Sean , Schaub Daniela , Hayashi Takahiro , Ligibel Mathieu , Sager Emine , Schroer Kirsten , Snajdrova Radka , Buller Rebecca
Published: October 2022

Enzymatic late‐stage diversification of small molecules has the potential to rapidly generate diversity in compound libraries dedicated to drug discovery. In this context, freestanding Fe(II)/α‐ketoglutarate‐dependent halogenases have raised particular interest as this enzyme family allows the otherwise difficult regio‐ and stereoselective halogenation of unactivated C(sp3)−H bonds. Here, we report the development of two engineered variants of the halogenase WelO5* for the racemic resolution of a mixture of stereoisomers generated in the synthesis of a bioactive martinelline‐derived fragment. By screening a 3‐site combinatorial variant library, we could identify two variants exhibiting exquisite substrate selectivity towards the desired enantiomers. Strikingly, the inversion of substrate stereopreference between the halogenase variants was achieved by varying only three residues in the active site. Protein crystallization and subsequent structure elucidation of the wildtype enzyme and a WelO5* variant shed light on the factors governing substrate acceptance and selectivity.
Photoredox Csp3−Csp2 Reductive Cross‐Couplings of Cereblon Ligands for PROTAC Linker Exploration in Batch and Flow
Authors: Steiner Alexander , Krieger Johannes , Jones Reinaldo , Böse Dietrich , Wang Yanping , Eggenweiler Hans‐Michael , Williams Jason D. , Kappe C. Oliver
Published: October 2022

Proteolysis‐targeting chimeras (PROTACs) have recently emerged as powerful molecules for targeted protein degradation. As such, synthetic methods for their modular synthesis are of prime importance in medicinal chemistry. We report the development of both batch and flow photoredox methodologies for Csp3−Csp2 cross‐electrophile couplings of alkyl bromides with E3 ligase‐binding aryl bromides (thalidomide and lenalidomide derivatives). Despite the challenging reaction system, containing several insoluble species, conditions were discovered to facilitate stable processing in an oscillatory flow photochemical reactor. The flow approach can enable processing of larger material quantities in a shorter time period. A range of saturated linker molecules, with various functional handles, were successfully combined with four ligand variants using the developed conditions. Finally, scalability in batch and use of an organic photocatalyst were explored.
Improved constant phase fractional order approximation method for induction motor FOPI speed controller
Authors: Adigintla Sudheer , Aware Mohan V.
Published: October 2022

This paper presents the digital realization of the fractional‐order PI (FOPI) controller fractional integrator element using the improved constant phase approximation method. A new pole‐zero rationalization approach is proposed within the bandwidth of the Bode phase plot. The voltage source inverter fed induction motor fractional‐order model has been identified. A novel mathematical FOPI controller design procedure for the identified FO plant model has been proposed. The designed FOPI controller fractional integrator element is implemented using the constant phase approximation method. A detailed comparative performance study of the proposed approximation method with the existing Charef, Oustaloup, and refined Oustaloup methods has been carried out using the Bode, Nyquist, and Nichols plots. The proposed FOPI controller is placed in the speed feedback loop of the rotor field‐oriented control algorithm of IM. To confirm the proposed FOPI controller approximation method's robustness, a hardware study is carried out on the laboratory hardware‐in‐loop (HIL) platform. In addition, variation in the number of pole‐zero pair's effect on the speed tracking performance, robustness against parameter and load variations are also analyzed.
Stereoselective Synthesis of the DE Ring Portion of Kadcoccilactone A by a Radical Addition/Cyclization Approach
Authors: Noguchi Kimihiro , Saito Sayuri , Yamakoshi Hiroyuki , Nakamura Seiichi
Published: October 2022

A stereoselective synthesis of the DE ring portion of kadcoccilactone A, triterpenoid isolated from Kadsura coccinea, has been achieved starting from a chiral building block, utilizing a photocatalytic decarboxylative addition/cyclization/fragmentation sequence to construct the five‐membered ring and intramolecular alkylation to create the quaternary stereocenter as key steps.
Electrochemical Investigation on Kinetics of Xanthine Metabolism and Inhibition Effect of Febuxostat on Xanthine Oxidase Activity
Authors: Liu Fuxin , Shang Tianyi , Han Lingling , He Nan , Liu Xiuhui
Published: October 2022

Xanthine is a significant biomolecule and its concentration level in urine and blood plasma is an indicator of specified pathological states. Here, a new sensing platform was designed, which showed excellent analytical performance for xanthine. Importantly, it is the first time to investigate the kinetics of xanthine metabolic reaction by electrochemical method. The results demonstrated that the conversion of xanthine to uric acid completely conformed to the Michaelis‐Menten kinetics. Furthermore, we also studied the inhibitory effect of febuxostat on xanthine oxidase activity detailed. As expected, the work may offer potential value for researchers in the treatment of hyperuricemia and gout.
Electrocatalytic enhancement mechanism of cobalt single atoms anchored on different MXene substrates in oxygen and hydrogen evolution reactions
Authors: Zhao Xin , Zheng Xuerong , Lu Qi , Li Ying , Xiao Fengping , Tang Bing , Wang Shixun , Yu Denis Y. W. , Rogach Andrey L.
Published: October 2022

Decorating single atoms of transition metals on MXenes to enhance the electrocatalytic properties of the resulting composites is a useful strategy for developing efficient electrocatalysts, and the mechanisms behind this enhancement are under intense scrutiny. Herein, we anchored Co single atoms onto several commonly used MXene substrates (V2CTx, Nb2CTx and Ti3C2Tx) and systematically studied the electrocatalytic behavior and the mechanisms of oxygen and hydrogen evolution reactions (OER and HER, respectively) of the resulting composites. Co@V2CTx composite displays an OER overpotential of 242 mV and an HER overpotential of 35 mV at 10 mA cm−2 in 1.0 M KOH electrolyte, which is much lower than for Co@Nb2CTx and Co@Ti3C2Tx, making it comparable to the commercial noble metal Pt/C and RuO2/C electrocatalysts. The experimental and theoretical results point out that the enhanced bifunctional catalytic performance of Co@V2CTx benefits from the stronger hybridization between Co 3d and surface terminated O 2p orbitals which optimized the electronic structure of Co single atoms in the composite. This, in turn, results in lowering the OER and HER energy barriers and acceleration of the catalytic kinetics in case of the Co@V2CTx composite. The advantage of Co@V2CTx was further validated by its high overall water splitting performance (1.60 V to deliver 10 mA cm−2). Our study sheds light on the origins of the catalytic activity of single transition metals atoms on MXene substrates, and provides guidelines for designing efficient bifunctional MXene‐based electrocatalysts.

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Who gets mad, sad, scared or happy at discipline? Emotion attributions explain child externalizing behaviour
Authors: de Oliveira Ebenézer A. , Mendes Deise M. L. F. , Pessôa Luciana F. , de M. Oliveira Susana K.
Published: October 2022

Few studies have linked parental discipline with children's emotional experiences, and not much data explore children's emotional attributions to discipline linked to externalizing behaviour. With a sample from Brazil, this study examines which emotions children most aptly attribute to a protagonist facing spanking, time‐out or inductive discipline for norm violations. We hypothesized that anger, sadness, and fear would have higher attribution rates at spanking or time‐out, relative to inductive discipline and that happiness would have higher attribution rates at induction relative to the other discipline modalities. We expected these findings to be more pronounced in older children. Based on emotional functions, we also tested the role of neutrality and happiness attributions to discipline in children's externalizing behaviour. A two‐way MANOVA, with discipline and child age as explanatory variables, showed that children attributed more anger at time‐out or spanking than at induction, and more happiness and neutrality at induction than at either time‐out or spanking. Older children attributed significantly more sadness and less fear or neutrality. Hierarchical regressions showed that child externalizing behaviour was negatively related to happy attributions in discipline independently of child emotion situation knowledge or demographics. The results are interpreted in light of a functional view of emotions.
Postdiagnosis recreational physical activity and breast cancer prognosis: Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis
Authors: Cariolou Margarita , Abar Leila , Aune Dagfinn , Balducci Katia , Becerra‐Tomás Nerea , Greenwood Darren C. , Markozannes Georgios , Nanu Neesha , Vieira Rita , Giovannucci Edward L. , Gunter Marc J. , Jackson Alan A. , Kampman Ellen , Lund Vivien , Allen Kate , Brockton Nigel T. , Croker Helen , Katsikioti Daphne , McGinley‐Gieser Deirdre , Mitrou Panagiota , Wiseman Martin , Cross Amanda J. , Riboli Elio , Clinton Steven K. , McTiernan Anne , Norat Teresa , Tsilidis Konstantinos K. , Chan Doris S. M.
Published: October 2022

It is important to clarify the associations between modifiable lifestyle factors such as physical activity and breast cancer prognosis to enable the development of evidence‐based survivorship recommendations. We performed a systematic review and meta‐analyses to summarise the evidence on the relationship between postbreast cancer diagnosis physical activity and mortality, recurrence and second primary cancers. We searched PubMed and Embase through 31st October 2021 and included 20 observational studies and three follow‐up observational analyses of patients enrolled in clinical trials. In linear dose‐response meta‐analysis of the observational studies, each 10‐unit increase in metabolic equivalent of task (MET)‐h/week higher recreational physical activity was associated with 15% and 14% lower risk of all‐cause (95% confidence interval [CI]: 8%‐22%, studies = 12, deaths = 3670) and breast cancer‐specific mortality (95% CI: 4%‐23%, studies = 11, deaths = 1632), respectively. Recreational physical activity was not associated with breast cancer recurrence (HR = 0.97, 95% CI: 0.91‐1.05, studies = 6, deaths = 1705). Nonlinear dose‐response meta‐analyses indicated 48% lower all‐cause and 38% lower breast cancer‐specific mortality with increasing recreational physical activity up to 20 MET‐h/week, but little further reduction in risk at higher levels. Predefined subgroup analyses across strata of body mass index, hormone receptors, adjustment for confounders, number of deaths, menopause and physical activity intensities were consistent in direction and magnitude to the main analyses. Considering the methodological limitations of the included studies, the independent Expert Panel concluded ‘limited‐suggestive’ likelihood of causality for an association between recreational physical activity and lower risk of all‐cause and breast cancer‐specific mortality.