bluuebunny/crossref_metadata_2025 huggingface dataset:
COMPARISON OF PATIENT SAFETY PERCEPTION IN PRECLINICAL AND CLINICAL STUDENTS
Authors: Simargi Yopi , Alvianto Steven
Published: August 2022

Background: Patient safety is a global problem and patient safety education for medical students is needed to improve the quality of health services. This study aimed to determine the mean difference of perception on nine patient safety key factors between preclinical students and clinical students.Methods: This observational analytic cross-sectional study was conducted on preclinical students and clinical students at the School of Medicine and Health Sciences of Atma Jaya Catholic University of Indonesia (AJCUI) in the academic year 2019/2020, randomly drawn in each batch. The research data was collected using the Attitude to Patient Safety Questionnaire -III (APSQ-III) with 7 Likert scales. Data analysis using independent t-test.Results: From 389 students, significant mean differences of patient safety perception between preclinical students and clinical were found for five key factors: PS training received (p = 0.000), Error reporting confidence (p = 0.000), Working hours as an error cause (p = 0.000), Team functioning (p = 0.001), and Patient involvement in reducing error (p = 0.000).Conclusion: Medical students had positive perceptions of patient safety. However, there were still some significant different perceptions between clinical and preclinical students, which indicated the need for patient safety education integration in the medical education curriculum.
THE DIFFERENCE IN GRADE POINTS BETWEEN MORNING AND EVENING CHRONOTYPES AMONG PRECLINICAL MEDICAL STUDENTS
Authors: Wangsa Cindy Leona , Prastowo Nawanto Agung , Juliawati Veronica Dwi Jani , Tjhay Francisca
Published: August 2022

Background: Every person has a different diurnal preference, sleep-wake cycle, and alertness known as chronotype. There are three chronotypes, that is morning, evening, and intermediate type. Medical students with evening chronotype are still forced to follow the standard academic schedule in the morning, hence their sleep time is reduced. This problem results in lower grade points since sleep quality affects academic achievement. This study aimed to analyze the difference in grade points between morning and evening chronotypes among medical students.Methods: A comparative cross-sectional study was performed among 102 preclinical students class 2018 of School Medicine and Health Sciences of Atma Jaya Catholic University Indonesia. All personal data, grade points, and chronotypes were taken using google form. Chronotypes and sleep characteristics were determined with Munich ChronoType Questionnaire (MCTQ) by calculating weekend mid-sleep time and sleep debt. Unpaired t-test and binary logistic regression were used to analyze the statistical significance.Results: The results of evening chronotype 44.1% respondents, morning chronotype 31.4% respondents, and intermediate chronotype 24.5% respondents were obtained from 102 respondents. There were 65.7% of students with grade points greater than or equal to three and 34.4%  lower than three. There was no significant difference in grade points between morning and evening chronotypes on semester 1, 2, 3, nor grade point average 3 (p>0.05). Conclusion: There is no significant difference in grade points between morning and evening chronotypes among preclinical students class 2018 of School Medicine and Health Sciences Atma Jaya Catholic University of Indonesia.
THIRD-YEAR HEALTH PROFESSIONS STUDENTS’ INTERPROFESSIONAL EDUCATION IN THE COMMUNITY SETTING: WHAT DID THEY EXPERIENCE?
Authors: Projosasmito Siti Rokhmah , Riskiyana Rilani , Supriyati Supriyati
Published: August 2022

Background: Learning by experiencing a real situation is believed to be more powerful than using simulation. This hypothesis is also applied to interprofessional learning for students in health professions education. Learning to collaborate and practice students' knowledge of health care in a community became the purpose of the community and family health care (CFHC) program in the Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada.Aim: To describe the third-year students’ experiences of learning interprofessional collaboration in a community setting based on their activity report.Case Discussion: The CFHC team created a particular design for third-year students, focused on community health problems rather than family health problems. The groups conducted focus group discussions to explore health issues and to decide together with the community the main problem that would be given intervention. The groups documented the entire process through a written report, video, and an article about their intervention outcome.Conclusion: The reports showed that students were able to demonstrate interprofessional practice in solving health problems in the community. They learned to work as an interprofessional team while experiencing it. Thus, conducting community-based IPE for undergraduate students is necessary to develop interprofessional collaboration competencies.
THE LEVEL OF KNOWLEDGE AMONG UNDERGRADUATE MEDICAL STUDENTS ABOUT STROKE
Authors: Fauziah Rita Arsika , Amalia Lisda , Oktavia Nandina , Rakhmilla Lulu Eva
Published: August 2022

Background: Stroke is a neurological emergency that requires prompt and precise diagnosis and treatment. However, errors in diagnosis and treatment are still frequently seen. One of the main causes of this problem is the lack of doctors’ knowledge. This study aims to determine the level of knowledge among undergraduate medical students about stroke. The results of this study can be used as basic information to provide educational interventions to medical students to prevent and minimize the occurrence of medical errors. Methods: This study used a quantitative-descriptive method with a cross-sectional approach. The study subjects were third-semester medical undergraduate students at the Medical Faculty of Padjadjaran University during the 2018/2019 academic year. Samples were 43 secondary data collected from ischemic and hemorrhagic stroke Students Objective Oral Case Analysis (SOOCA) exam scores and 168 primary data collected using a 30-item questionnaire regarding stroke knowledge. The data obtained was then analyzed descriptively and the result was categorized into 3 levels of knowledge: Good, moderate, and poor. Results: Each variable demonstrates a varying degree of knowledge. However, based on the total scores and averages collected from both the questionnaire and the SOOCA exam, most of the students had a moderate level of knowledge regarding ischemic and hemorrhagic stroke. Conclusion: Most of the students had a moderate level of knowledge about stroke, so educational interventions and student’s capabilities improvement are required to increase knowledge of stroke.
Non-Return Educational Migration from Rural Kalmykia: Characteristics and Risks for the Region
Authors:   Kalmyk Scientific Center of the RAS, Badmaeva Nogan
Published: August 2022

Non-return educational migration tends to become a topical problem of the Republic for it entails considerable risks, such as shortage of qualified manpower, decreased intellectual potential, losses of childbearing age groups, endangered ethnic culture and language, etc. Goals. The article aims to analyze results of in-depth interviews for characteristics of educational — and further labor — migration from rural Kalmykia to Moscow and St. Petersburg. Materials and methods. The qualitative study of non-return educational migration examines a total of 20 in-depth phone interviews. Results. In most cases, educational migrations to megalopolises turn into labor ones to be further aggravated with a home purchase and consummation of marriage. The youth migration threatens the preservation and transmission of ethnic culture, traditions and language both in the Republic and in places of actual residence of such migrants.
Analyzing Supply and Demand in Tuva’s Labor Market: Professional and Gender Aspects Revisited
Authors:   Institute of Sociology, Federal Center of Theoretical and Applied Sociology of the RAS, Gorina Tatiana , Natsak Organa ,   Tuvan Institute for Humanities and Applied Socioeconomic Research, Government of the Tyva Republic
Published: August 2022

Goals. The first in-depth study of Tuva’s labor market analyzes data obtained via hardware/software monitoring solutions created by National Labor Research Institution (Ministry of Labor of Russia) for actual demand and supply structures. Results. The paper compares and introduces qualitative and quantitative characteristics of CVs and vacancies; considers demand and supply figures by professional groups, educational levels and qualifications; compares the existing vacancies to sociodemographic characteristics of Tuva’s unemployed residents according to official statistical data. Special attention is paid to gender, educational, and age parameters of job applicants from online resources — and actual job offer requirements. The work also provides comparative insights into levels of wages mentioned in job applications and offers respectively, rates industries by number of vacancies, explores representativeness of potential employers registered in other regions of Russia. Conclusions. The article shows Tuva’s labor market is vividly characterized by ‘skills mismatch’, i.e. a misbalance between demand and supply in terms of professions and qualifications — whether involving university degrees or without the latter — that shall keep aggravating the unemployment agenda and adversely influence household incomes.
The Nāga King: One Jātaka from The Garland of Stories of Teacher’s Past Lives Revisited
Authors:   Kalmyk Scientific Center of the RAS, Maksimova Olga
Published: August 2022

Introduction. Jātakas are a most popular genre of Buddhist literature. The Garland of Stories of Teacher’s Past Lives from Collected Works of the Successive Embodiments of the Karmapas (1st to 10th and 13th to 15th) is of interest due to its relevance to the Buddhist doctrine of ten pāramitās — bodhisattva’s perfect deeds to be observed by followers. The plot of The Nāga King narrates a special deed of the Buddha practiced by him in one of his past lives. Goals. The paper aims to introduce data on the mentioned jātaka for scientific use from Buddhist Digital Resource Center (BDRC). Results. The Garland of Stories of Teacher’s Past Lives comprises 100 jātakas. This collection was published by Nationalities Languages Press (Beijing) under the title ‘100 Stories of Buddha’s Past Lives’ that also included 100 jātakas. Our analysis of the Lhasa and Beijing editions shows texts of jātaka 68 (The Nāga King) have though minor discrepancies. The moral is associated with the pāramitā of ‘skillful means’, i.e. one of the 10 special deeds practiced by a bodhisattva on the way to Buddhahood.
Entre la religión y el arte
Authors: Méndez Aguirre Víctor Hugo
Published: August 2022

Reseña de Blanca Solares, Madre terrible: La diosa en la religión del México antiguo. Barcelona, UNAM/Ánthropos, 2007, 430 pp.
Loan Repayment Ability Using Machine Learning
Authors: Nemade Suyog
Published: August 2022

Abstract: Loan lending has risen quickly around the world in recent years. The fundamental goal of loan lending is to eliminate intermediaries such as banks. Loan lending is a fantastic option to apply for a loan for a small business or an individual who does not have enough credit or a credit history. However, the basic issue with loan lending is information asymmetry in this paradigm, which may not accurately predict lending default risk. Lenders solely decide whether or not to finance the loan based on the information supplied by borrowers, resulting in imbalanced datasets containing uneven completely paid and default loans. Unfortunately, the unbalanced data are hostile to traditional machine learning approaches. In our case, models with no adaptive strategies would concentrate on learning the standard payback. However, the minority class's characteristics are crucial in the lending sector. We use re-sampling and cost-sensitive procedures to analyse unbalanced datasets in this work, in addition to multiple machine learning schemes for forecasting the default risk of loan lending. Furthermore, we validate our suggested strategy using Lending Club datasets. The experiment findings suggest that our proposed technique may effectively improve default risk prediction accuracy.
Partial Replacement of Fine Aggregate by Glass Powder in Concrete
Authors: Ansari Tanveer
Published: August 2022

Abstract: The concrete trade is one in every of the biggest customers of natural resources because of that property of concrete trade is underneath threat. The environmental and economic concern is that the biggest challenge the concrete trade is facing, the problems of environmental and economic concern are self-addressed by the utilization of waste glass as partial replacement of fine aggregates in concrete. In order to improve the mechanical properties of concrete fine aggregates will be replaced by waste glass powder as 20% ,25 and 30% weight for M-45 design mix. The concrete specimens will be tested for compressive strength at 7 ,14 and 28 days respectively and Split tensile Strength at 7 and 28 days and Compressive Strength test at 28 days also the results obtained will be compared with those of traditional concrete.
Intricate Twitternlp Modelling
Authors: Gawande Aditi Ashish
Published: August 2022

Abstract: In this research, we introduce TweetNLP, a platform for social media Natural Language Processing (NLP). An extensive range of NLP tasks are supported by TweetNLP, including standard focus areas like sentiment analysis and named entity recognition as well as social media-specific tasks like emoticon prediction and offensive language detection. Task-specific systems run on moderately small Transformer-based language models that are focused on social media text, particularly Twitter, and don't require specialized hardware or cloud services to operate. TweetNLP's major contributions are: (1) an integrated Python library for a contemporary toolkit supporting social media analysis using various task-specific models tailored to the social domain; (2) an interactive online demo for codeless experimentation using our models; and (3) a tutorial covering a wide range of typical social media applications.
The National Rural Water and Sanitation Project (1985-1989) in Brazil: limits and potentials
Authors: Roland Nathalia , Heller Léo , Rezende Sonaly
Published: August 2022

In this article, the principles of the National Rural Water and Sanitation Project (PNSR), elaborated during the 1980s, are analyzed, discussing the advances and the limits reached in the development of rural water supply and sanitation in Brazil. The methodology used was an analysis of the content of documents and interviews with key actors. The results have demonstrated that the formulation of the PNSR promoted a new contribution of knowledge to the water and sanitation sector in Brazil, bringing innovations concerning the approach to water and basic sanitation in rural areas, especially relating to its integration with health, the processes of education and social participation, the decentralization of services, the use of appropriate technologies and community involvement in the management of services. Although it did not result in a government program, the legacy left by the PNSR has provided a great contribution in the form of studies, which are still relevant today.
Communicating urgency through humor: School Strike 4 Climate protest placards
Authors: Hee Matthew , Jürgens Anna-Sophie , Fiadotava Anastasiya , Judd Karina , Feldman Hannah R.
Published: August 2022

Protest placards are an important part of School Strike 4 Climate (SS4C) protest culture and illustrate how protesters view, understand and share their environmental concerns. Many of the placards use humor to convey the messages of their creators. Bringing together science communication and humor studies, this paper examines the communicative functions of humor in Australian SS4C posters by asking to what extent protest signs can be understood as a vehicle of science communication. The paper reveals how humorous protest placards become the means of grassroots creativity, exploring bottom-up science communication in an ambiguous, but accessible and enjoyable form.
Cost Effective Ossicular Reconstruction- A Case Report
Authors: Ramanathan Sumitha , Govarthanaraj Aberna
Published: August 2022

Ossicular reconstruction using various materials from autograft to artificial prosthesis have a wide range of success and failure rates due to various reasons. In this article, a newer use of old grommet in ossicular reconstruction is attempted. A 50yr old lady presented with hearing loss in the right ear for one year. She gave a previous history of ear discharge 11 months back. There was no other positive history relevant to the case. On examination, the pars tensa was plastered and immobile on the left side. Her Pure tone audiometry showed conductive hearing loss on the left ear with average 55 db loss. Her CT showed absent incus with obliteration of middle ear-space and sclerosed mastoid. We planned for Tympanotomy. On elevating the flap, the incus and stapes were absent. Here we decided on a newer use for the grommet and used it as prosthesis. The result is good and promising with no complications. The grommet did not get extruded or produce granulation tissue. The ear is dry and the patient is still on follow up. The purpose of publishing this report is to identify a prosthesis that is cost-effective and readily available. The grommet has been used for a more extended period for other indications,but as a prosthesis for reconstruction is a new method and requires further studies.
A Case of Unilateral Pseudoglioma of Eye in A Neonate
Authors: Hamsa V.S. , Jagadeeswari S.
Published: August 2022

Pseudoglioma is a condition presenting as leukocoria other than retinoblastoma. Persistent hyperplastic primary vitreous is a type of pseudoglioma in an ocular developmental defect in which the hyaloid vasculature within the vitreous overgrows and fails to regress.In this case , 25 days old female child presented with the complaints of white pupillary reflex in the right eye since birth. Baby was born to second degree consanguineous parents. The child was born at full-term by normal delivery. The Antenatal period was uneventful. No history of oxygenation and birth trauma. Anterior segment examination of the right eye showed a shallow anterior chamber and leukocoria. Lens was cataractous and vascular. The left eye was normal. Examination under anesthesia revealed normal corneal diameter and Intraocular pressure in both the eyes. Fundus examination was normal in the left eye and cannot be performed in the right eye. Ultrasound B-scan in the right eye showed an echogenic band in the posterior surface of the lens and on colordoppler arterial blood flow was seen in the band. Hence, the patient was diagnosed to have Anterior persistent hyperplastic primary vitreous in the righteye.In this case ,child is advised to undergo Right lensectomy with cautery of the persistent anterior hyaloid stalk and anterior vitrectomy.
EDUCAÇÃO DE JOVENS E ADULTOS TRABALHADORES E RELAÇÕES ÉTNICO-RACIAIS E ENSINO DE GEOGRAFIA
Authors: Silva Douglas Basilio da , Silva Tiago Dionisio
Published: August 2022

O presente artigo traz para a discussão o tema da Educação de Jovens e Adultos e suas intersecções nos campos das relações étnico-raciais e de classe, associando ainda ao ensino da Geografia. O objetivo aqui é apresentar um levantamento das pesquisas acadêmicas realizadas sobre os temas centrais “Educação de Jovens e Adultos Trabalhadores, Questão Racial e Ensino de Geografia”, usando como método a busca pelo Estado da Arte. Desse modo, foram realizados amplo levantamento e análise das pesquisas acerca do tema no período entre 2006-2016 nas principais associações e revistas especializadas. Pretendeu-se com isso cartografar, ou seja, mapear as pesquisas que envolvem as referidas temáticas.
TERRITORIALIZAÇÃO UNDERGROUND NA METRÓPOLE
Authors: Silva Glaycon de Souza Andrade e
Published: August 2022

Investigar a cultura Hip-Hop pelo viés da ciência geográfica é uma temática emergente e compõe um campo da ciência denominado de Geografia Marginal, e almeja, principalmente, alcançar uma visibilidade dessa cultura suburbana no debate acadêmico e científico. Nesse sentido, o presente estudo tem por objetivo compreender a evolução espaço-temporal da cultura Hip-Hop ao longo de duas décadas, desde 1990 até 2009, na cidade de Belo Horizonte. Para tanto, a metodologia se baseou no levantamento de dados secundários e na confecção de cartografias dos territórios undergrounds na capital mineira. De acordo com os resultados obtidos na pesquisa, pode se inferir que ao longo do espaço-tempo houve processos de territorialização, desterritorialização e reterritorialização dos territórios do Hip-Hop, verificando-se a tendência de estabelecimento de territórios em espaços públicos tanto centrais quanto periféricos da cidade, e, além disso, nota-se que há espaços privados que possuem capacidade de reconhecer e agregar essa cultura junto ao cenário cultural underground belo-horizontino.
Documentary and Fiction in the Literature of Travel
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Guminsky Viktor M.
Published: August 2022

Author’s attention is focused on the form correlation of real life and literature, authenticity (documentary evidence) and fiction, change in space and time perception. Theoretical analysis is based on the great amount of historical and cultural materials, beginning with the ancient epochs (antiquity, Middle Ages). The complex approach to the study of this material allows validating the conception of the travel genre origin and development as an implementation of the archetypical model of a “journey” in literature: journey as the course of life (in folklore); journey as the world discovery and self-discovery (in philosophy); journey as the wandering along the land surface and the space of your own thoughts (actual travels, imagination journeys, etc.).
Memoir and Biographical Literature about Gogol: on the Apocryphal Nature Issue
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Vinogradov Igor A.
Published: August 2022

Gogol’s legacy itself is the most important document of the era. It is precisely because of its importance that a sharp ideological struggle unfolded around Gogol’s works immediately after their publication. The struggle for Gogol’s legacy continued after his death, not only in criticism, but also in the memoirs dedicated to him. The article analyzes the apocryphal features in the memoirs of Gogol by S.T. Aksakov, P.V. Annenkov, A.T. Tarasenkov, in biographical works about Gogol by P.A. Kulish, V.I. Shenrok and others. Based on the study of the entire corpus of memoirs and testimonies about Gogol by his contemporaries, published in 2011–2013, and replenished in 2017–2018, a number of sources of lesser and dubious, in comparison with others, reliability are identified and characterized. All Gogol memoirists had, in one way or another, their own interest, which did not always coincide with the desire to convey the true appearance of the writer. However, in some cases, the subjective intentions of the author led to a distortion of the true appearance of the writer. Among such reasons, ideological preferences of memoirists belonging to various liberal opposition trends (Westernism, Slavophilism, Ukrainophilism, etc.), as well as the corporate interests of the medical class, are noted as the most important.
“The Whole Day Is Like Crystal”: on a Possible Source of F.I. Tyutchev’s Famous Epithet
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Akimova Maria S.
Published: August 2022

The article describes the version of the emergence of F.I. Tyutchev’s famous image “crystal day” in his poem “There is in the beginning of autumn…” (1857). Based on Tyutchev’s creative method (work on the road, significant influence of “external” impressions on the poetic world), memoirs of his environment and other factors, the author comes to the conclusion that the birth of the epithet “crystal” could be influenced by the Transfiguration Church with a crystal interior (1855), located in relative proximity to the Tyutchev’s estate Ovstug.
Author’s Presence in the Novel “Anna Karenina”: Documentary in Artistic
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Gorodilova Natalia I.
Published: August 2022

The article is devoted to the synthesis of artistic and documentary principles in the novel “Anna Karenina”. An appeal to memoirs and epistolary sources made it possible to identify the documentary sources of a number of novel events, prototypes of heroes both main and secondary, mental interests and everyday features of the era reflected in the artistic fabric of the work. All these facts clearly testify to the topicality of “Anna Karenina”, saturated with the spirit of the 1870s. The scientific novelty of this work lies in the fact that the issue of subjectivity of the novel is considered in the context of the creative and spiritual evolution of the author, each stage of which had its own moral dominant, mood. The world outlook crisis of Tolstoy, which preceded his new understanding of life, was reflected in his work on the novel. The story of Levin with his painful search for the meaning of life, religious doubts embodied the innermost thoughts of the author, which he repeatedly expressed in letters to N.N. Strakhov. The novel becomes the artistic embodiment of religious and philosophical thoughts of the writer and precedes the most important stage in his biography. It is no coincidence that after “Anna Karenina” Tolstoy published “Confession”. The kinship of artistic and journalistic works not only testifies to the undoubted proximity between Levin and Tolstoy, but also outlines serious differences between them.
ANALISIS PENDAPATAN USAHA COKELAT OLAHAN PADA INDUSTRI UKM SAKAYA DI KOTA PALU
Authors: Palamma Didin , Sulaeman Sulaeman
Published: August 2022

Cocoa (Theobroma cacao L) is a cultivated tree originating From South America, from which cocoa beans are produced a processed product known as chocolate when developed throungh the Agro-industry. One of the well-known industries in Palu City today is the Sakaya SME Industry. The Sakaya UKM Industry produces unique chocolate products both in taste, packaging from, in terms of type, and the distinctive aroma of the chocolate. This study aims to determine how much the income level of the chocolate business in the Sakaya BTN Pengawu, West Palu, Palu City in January 2020. The thetermination of respondents in this study was carried out purposively, the selected respondents were owners and employees from both the

production and marketing departements of the industry. Sakaya UKM. The data used in this research comes from primary data and secondary data. The analysis used is Income analysis. The results showed that the income earned in November and December 2019 was Rp. 16.958.751. For Conventure chocolate. Convecture chocolate is produced every month according to consumer demand. From November to December, Convecture chocolate Demand was made so that the 2019 Sakaya UKM’s Conventure Chocolate income was quite good.
A sequence-based foldability score combined with AlphaFold2 predictions to disentangle the protein order/disorder continuum
Authors: Bruley Apolline , Bitard-Feildel Tristan , Callebaut Isabelle , Duprat Elodie
Published: August 2022

Order and disorder govern protein functions, but there is a great
diversity in disorder, from regions that are – and stay – fully
disordered to conditional order. This diversity is still difficult to
decipher even though it is encoded in the amino acid sequences. Here, we
developed an analytic Python package, named pyHCA, to estimate
the foldability of a protein segment from the only information of its
amino acid sequence and based on a measure of its density in regular
secondary structures associated with hydrophobic clusters, as defined by
the Hydrophobic Cluster Analysis (HCA) approach. The tool was designed
by optimizing the separation between foldable segments from databases of
disorder (DisProt) and order (SCOPe (soluble domains) and OPM
(transmembrane domains)). It allows to specify the ratio between order,
embodied by regular secondary structures (either participating in the
hydrophobic core of well-folded 3D structures or conditionally formed in
intrinsically disordered regions) and disorder. We illustrated the
relevance of pyHCA with several examples and applied it to the
sequences of the proteomes of 21 species ranging from prokaryotes and
archaea to unicellular and multicellular eukaryotes, for which structure
models are provided in the AlphaFold2 databases. Cases of low-confidence
scores related to disorder were distinguished from those of sequences
that we identified as foldable but are still excluded from accurate
modeling by AlphaFold2 due to a lack of sequence homologs or to
compositional biases. Overall, our approach is complementary to
AlphaFold2, providing guides to map structural innovations through
evolutionary processes, at proteome and gene scales.
Indel Error Correction Codes for DNA Digital Data Storage and Retrieval
Authors: G NallappaBhavithran , R Selvakumar
Published: August 2022

A procedure for storage and retrieval of Digital information in DNA
strings is discussed by constructing an error correction code which is
capable of correcting indel errors and maintaining the stability of DNA
strings. For correcting indel errors, Varshamov–Tenengolts algorithm is
used. In the VT algorithm, syndrome is calculated using the position
values of the retrieved word. Then, the wrongly added or deleted
positions can be found by the syndrome and weight of the retrieved word.
The stability of DNA strings depends on the proportionate occurrence of
guanine (G) and cytosine (C). Reverse complementary property is
essential for preventing de-hybridization. To ensure these properties,
VT encoded information is mapped to DNA strings by appropriate choices
of group homomorphisms. Code for any desired length(n) can be created
using the construction methods presented in this paper. The code’s
reverse complement distance is calculated by using the value of n.
A Proposed ICH Guideline for Biosimilars Approval
Authors: Niazi Sarfaraz
Published: August 2022

Guidelines for the approval or licensing of biosimilars have evolved
over the past 18 years since the first introduction of biosimilars.
Amendments to these guidelines are constrained in the US by legislation
and in the EU and WHO due to collaborative consent requirements. The
MHRA has recently joined ICH and brought its guideline that is most
rational and scientific; it removes animal and clinical efficacy
testing, as evidenced by hundreds of studies, billions of doses
administered, and a better understanding of recombinant therapeutic
proteins. However, there remains a need to bring a neutral jurisdiction
guideline that all countries can adopt; while the EU, FDA, Japan, and
now the UK are the deciding countries, they all realize the shortcomings
and will be willing to support an ICH guideline, as proposed here.
Compliance with a unified ICH guideline will promote the entry of safer
biosimilars and cross-country registrations. This review is based on
identifying the shortcomings of the current regulatory guidelines and
scientific data to support the amendments proposed. These
recommendations have been submitted to the ICH and are under
consideration in the pre-Stage 1 consensus-building evaluation that will
require comments of scientists and regulatory authorities. A new ICH
guideline for the approval of biosimilars will bring global harmony and
enhanced accessibility of safer biosimilars.
Shear wave elastography for detecting placental abnormalities in type 1 and type 2 diabetes: a systematic review and meta-analysis.
Authors: Gupta Akhil , Immanuel Jincy , Ho Vincent , Dalal Raiyomand , Symons Patricia , Simmons David
Published: August 2022

Background: Diabetes prior to conception may cause pregnancy
complications through disruptions of placental function. Objectives/Key
Questions: 1) To describe placental changes in women with pre-existing
diabetes. 2) To determine if elastography can detect in-vivo placental
changes? Search Strategy: PubMed, Embase, Medline, Cochrane database
searches of English language reports published until July 2020.
Selection Criteria: Question 1: Any study describing placental
histopathology in women with known diabetes. Question 2: Any study using
elastography to report in-vivo placental stiffness values. Data
Collection and Analysis: For Key Question 1: we grouped placental
pathologies using Amsterdam International Consensus Group definitions.
For Key Question 2: we conducted a meta-analysis of placental stiffness
scores reported in metres per second (m/s) or kilopascals (kPa). Main
Results: Cumulative data from 14 studies showed no placental
histopathology features pathognomonic for diabetes. Pooled analysis of
14 studies included 478 “high risk pregnancies” and 828
control/healthy pregnancies. Only one study reported stiffness scores
for placentas of women with pre-existing diabetes (N < 10
women). Maternal-derived pathologies resulted in higher placental
stiffness with mean difference 4.5kPa (95% CI 3.16, 5.87) compared to
control / healthy pregnancies. Fetal-derived pathologies resulted in
higher placental stiffness with mean difference of 6.5kPa (95% CI 1.08,
11.86) compared to control / healthy pregnancies. Conclusions: Shear
Wave Elastography may provide in-vivo approximation of placental
histopathology. Further studies in women with pre-existing diabetes may
confirm this. Funding: primary author (AG) receives Western Sydney
University Postgraduate Research Scholarship (Ainsworth Trust) and
Australian Federal Government Research Training Program (RTP) Fees
Offset.
Medication Deprescribing Among Patients With Type 2 Diabetes: A Qualitative Case Series of Lifestyle Medicine Practitioner Protocols
Authors: Bradley Michael D. , Arnold Matthew E. , Biskup Bradley G. , Campbell Thomas M. , Fuhrman Joel , Guthrie George E. , Kelly John H. , Lacagnina Salvatore , Loomis James F. , McMacken Michelle M. , Trapp Caroline , Karlsen Micaela C.
Published: August 2022

This study is a qualitative case series of lifestyle medicine practitioners’ protocols for medication de-escalation in the context of reduced need for glucose-lowering medications due to lifestyle modifications. Increasing numbers of lifestyle medicine practitioners report achieving reductions in medications among patients with type 2 diabetes, and in some cases remission, but limited data exist on the clinical decision-making process used to determine when and how medications are deprescribed. Practitioners interviewed here provide accounts of their deprescribing protocols. This information can serve as pilot data for other practitioners seeking examples of how deprescribing in the context of lifestyle medicine treatment is conducted.
Esthetic Crown Lengthening Surgery – A 30-Year Retrospective and Lessons Learned
Authors: Robbins JW
Published: August 2022

Esthetic crown lengthening (ECL) surgery has been available to our profession for more than 30 years. The objective of this article is to discuss the author’s evolution in the techniques associated with ECL surgery. Several technical modifications related to initial incision, ostectomy, and tissue placement will be discussed. In addition, reasons for tissue rebound will be discussed.
Interfacial Bond Strength and Morphology of Sound and Caries-affected Dentin Surfaces Bonded to Two Resin-modified Glass Ionomer Cements
Authors: Al-Hasan RM , Al-Taee LA
Published: August 2022

Objective

To evaluate the shear bond strength and interfacial morphology of sound and caries-affected dentin (CAD) bonded to two resin-modified glass ionomer cements (RMGICs) after 24 hours and two months of storage in simulated body fluid at 37°C.

Methods and Materials

Sixty-four permanent human mandibular first molars (32 sound and 32 with occlusal caries, following the International Caries Detection and Assessment System) were selected. Each prepared substrate (sound and CAD) was conditioned (10% polyacrylic acid) and bonded to Activa BioACTIVE Restorative (Activa) and Fuji II LC (F2LC) as per the manufacturers’ instructions. Shear bond strength (SBS) was performed after 24 hours and two months of storage. The interfacial surfaces were examined using a digital microscope and scanning electron microscope (SEM). Three-way ANOVA, Bonferroni post-hoc tests (α=0.05), and independent T-tests were used for multifactorial analysis.

Results

Activa exhibited reduced bond strength values to sound and CAD in comparison to F2LC after two time periods (p=0.01). There is a pronounced enhancement in SBS of F2LC when bonded to CAD (p=0.01) after storage, with no statistically significant effect on sound dentin (p=0.309). Activa showed stable SBS to sound and CAD immediately and post-aging (p>0.05). However, the evidence of mineral-like deposits under an SEM attached to the aged, debonded dentin surfaces, thereby obliterating the exposed dentinal tubules, might support the tissue repair potential of Activa.

Conclusions

The SBS of Activa was lower than F2LC when bonded to sound and CAD, but the bonding stability and sealing ability is advantageous in minimally invasive therapy, suggesting use with a resin composite coverage when used in stress-bearing areas.
Demographic ageing: the rigidity of conventional metrics and the need for their revision
Authors: Valente Rosa Maria João
Published: August 2022

This article aims to discuss the scope and value of the conventional metrics used to assess and compare levels of ageing between different populations. The age brackets for classifying if the population is ageing or aged are typically based on chronological age and are very close to the stages of the economic tripartite life cycle: the school/education phase; the labour market participation phase; the retirement phase. Those conventional metrics produce distortions in capturing the levels of demographic ageing. If the change in the age structure is rooted in social development, not in a social crisis, having more people in older ages should be related to that. Living longer, on average, does not only mean living more years but also a change in people's social profile, which the usual metrics for measuring ageing do not capture. Because of the central place that demographic ageing occupies in the framework of social, political and scientific reflection on the present and future of societies, Demographic Science should contribute with new metrics reflecting the real social improvements in populations age structures. This reflection supports the need to undertake a critical analysis of the way demographic ageing has usually been presented; stresses the need to advance ageing metrics that match societies' development by considering the life expectancy; and presents a new indicator for measurement demographic ageing that compares what we observe with what we can expect from the age structure at any given mortality level.
Entrevista Orlando Silva
Authors: Segurado Rosemary
Published: August 2022

entrevista Orlando Silva
Protagonismo estético do corpo gordo feminino: considerações sobre La Playa de Fernando Botero.
Authors: Gomes Nathália Cardoso , Tonnetti Flávio Américo
Published: August 2022

O artigo discute a representação do corpo gordo feminino na obra do artista colombiano Fernando Botero, evidenciando de que maneira o artista se opõe a um modelo de representação, quase sempre hegemônico, que estigmatiza e marginaliza esse corpo, associando-o à gula, à preguiça, à doença, ao descontrole e à feiura. Pretende-se investigar, ainda, as diferentes percepções sobre os padrões de beleza em diferentes momentos sócio-históricos. Objetiva-se resgatar o olhar sobre o corpo gordo feminino associando-o à beleza, através de uma revisão sobre as estéticas do corpo feminino e do corpo gordo no cânone artístico, dando ênfase às figuras da Vênus, e a um conjunto de reflexões sugeridas pelo quadro “La Playa”, pintado por Botero em 1998.
Como dois estudantes de 22 anos puseram de pé o Sleeping Giants Brasil
Authors: Chicarino Tathiana Senne , Raíces Carlos , Segurado Rosemary , Ferraz Cláudia
Published: August 2022

Ainda no início da preparação de seu TCC sobre fake news e discurso de ódio, o estudante de Direito Leonardo de Carvalho Leal, da Universidade Estadual de Ponta Grossa (PR), leu na noite de 17 de maio do ano passado reportagem no El País Brasil sobre como o Sleeping Giants estava levando à falência vários sites de extrema-direita nos Estados Unidos, entre eles o Breitbart News de Steve Bannon. Eufórico com a descoberta, passou a madrugada pesquisando. De manhã, ele e sua namorada Mayara Stelle, também estudante de Direito da mesma faculdade de Ponta Grossa, ambos com 22 anos, já estavam com o Sleeping Giants Brasil no ar, com milhares de seguidores e forçando empresas a retirarem patrocínio de sites de extrema-direita que se financiam veiculando fake news e pregando o ódio. Nessa entrevista à Aurora, Leonardo e Mayara contam como tudo começou; a estratégia de convencimento das empresas e de desmonetização da indústria desinformativa; o rápido sucesso do movimento; as perseguições e ameaças que sofrem ainda hoje.
Qualidade de vida relacionada à deglutição em pacientes com câncer de cabeça e pescoço
Authors: Mores Carla , Rolim Maria Rita Pimenta , Souza Cintya Meneghel de , Grando Liliane Janete , Mituuti Cláudia Tiemi
Published: August 2022

Introdução: No câncer de cabeça e pescoço (CCP), as sequelas relacionadas aos tratamentos e à própria localização do tumor podem trazer alterações físicas e funcionais, com impacto na qualidade de vida (QV) destes pacientes. Objetivo: mensurar o impacto do câncer de boca sobre a qualidade de vida relacionada à deglutição e saúde bucal em pacientes com câncer de cabeça e pescoço, após tratamento médico com radioterapia e/ou cirurgia. Métodos: participaram do estudo dez pacientes em pós-tratamento médico para o CCP e que foram submetidos aos questionários de qualidade de vida M.D. Anderson Dysphagia Inventory (MDAD), Oral Health Impact Profile (OHIP-14) e Questionário de Qualidade de Vida da Universidade de Washington (UW-QOL). Resultados: Os resultados dos domínios emocional e funcional do protocolo MDADI demonstraram médias positivas, enquanto o domínio físico apresentou médias que demonstraram baixo funcionamento do dia-a-dia e qualidade de vida. A partir do questionário OHIP-14, verificou-se que 40% dos participantes foram classificados com alto índice de impacto na saúde bucal. As dimensões ‘’desconforto psicológico’’ e ‘’deficiência’’ impactam negativamente na QV dos pacientes. “Atividade’’ e “saliva” foram os problemas mais relatados, mostrando que, ‘’saliva’’, ‘’humor’’ e ‘’mastigação’’ foram os três domínios mais importantes na visão dos pacientes, verificado a partir do protocolo UW-QOL. Conclusão: Apesar do número reduzido de pacientes e da heterogeneidade de localização dos tumores, os resultados demonstram que o CCP e as sequelas de seu tratamento podem impactar de maneira significativa a QV dos pacientes em diversos domínios.
Benefícios do treinamento auditivo para idosos usuários de aparelhos de amplificação sonora individual (AASI)
Authors: Magri Natana , De Barba Marion Cristine
Published: August 2022

Introdução: Os Aparelhos de Amplificação Sonora Individual (AASI) são considerados como uma ajuda externa e não solucionam todos os obstáculos de comunicação. Muitos idosos não apresentam bom aproveitamento da amplificação sonora, pois as próteses auditivas não fornecem as habilidades comunicativas ou equivalem à função natural do sistema auditivo. O Treinamento Auditivo tem como princípio desenvolver a neuroplasticidade, promovendo mudanças nas habilidades auditivas e desempenho auditivo mediante estimulação, permitindo que o idoso aprenda a vivenciar os sons de maneira significante. Objetivo: Verificar os benefícios do treinamento auditivo em idosos usuários de AASI. Metodologia: Trata-se de uma revisão integrativa. Foram pesquisados artigos nas bases de dados CAPES, SciELO e LILACS, e selecionados aqueles que atendiam aos critérios de inclusão. A questão norteadora que compôs o estudo foi a seguinte: “Quais os benefícios que o treinamento auditivo proporciona aos idosos usuários de próteses auditivas?” Resultados: A partir das combinações dos Descritores em Saúde (DeCS), obteve-se uma amostra de 318 artigos. Após o processo de análise, restaram 6 artigos para responder à questão proposta. Conclusão: O Treinamento Auditivo ocasionou melhora das habilidades de figura-fundo, integração binaural, ordenação e resolução temporal, em idosos usuários de AASI. A associação entre o uso das próteses auditivas e o treinamento auditivo, além de proporcionar audibilidade das informações acústicas, potencializa as habilidades envolvidas no processamento auditivo, independentemente da idade.
GeoGebra Notes: um recurso dinâmico para o ensino de matemática
Authors: LIMA Jeferson Moizés , CORRÊA Valdir José Junior
Published: August 2022

Este relato apresenta uma experiência vivenciada por um professor de matemática do Ensino Médio com a utilização de uma nova ferramenta do GeoGebra, denominada Notes. Este recurso, permite a resolução de uma situação-problema, utilizando todos os recursos já presentes na plataforma do GeoGebra e ainda a utilização de uma caneta, com auxílio de um mouse, caneta touch ou o dedo para escrever e sublinhar, ferramenta que fazia falta para expressar diferentes registros de representação de um mesmo objeto matemático, principalmente no que se refere à representação algébrica, a qual exige a escrita em notação matemática. Aqui, compartilharemos a forma como esta ferramenta pode ser explorada em aulas presenciais e remotas, bem como suas potencialidades e limitações no ensino da matemática, especificamente em uma atividade sobre geometria analítica. Tal atividade contemplou questões sobre a geometria analítica do ponto e da reta, explorando os diferentes tipos de representação da reta, em uma turma de Ensino Médio. O uso do GeoGebra Notes possibilitou um ambiente que apoia discussões colaborativas, permitindo assim, que os alunos, presencialmente ou remotamente, tivessem um papel ativo no processo de comunicação durante a aula, gerando oportunidades para reestruturação de conhecimentos durante a interação social e do feedback proporcionado pelos próprios alunos.
Jogos Olímpicos Tóquio 2020: uma análise correlata com a pandemia da COVID-19 e a vacinação.
Authors: Santos Thaina Pereira dos , Terra Ana Paula Macedo , Medeiros Diogo
Published: August 2022

O presente artigo debruçou-se em analisar o evento esportivo mundial denominado Jogos Olímpicos, em sua edição Tóquio 2020, sob a perspectiva da pandemia do Novo Coronavírus, a qual impôs diversas barreiras sanitárias como obstáculo à ocorrência do evento, assim como acentuou as gritantes diferenças entre as nações participantes dos Jogos, no que tange ao avanço da vacinação dos atletas. A pesquisa foi realizada mediante a análise de textos históricos e de importantes conceitos jurídicos  presentes dentro do Direito Desportivo e do Direito Internacional, com objetivo de embasar os entendimentos alcançados. Os resultados alcançados foram o entendimento de que, tanto a historicidade dos Jogos, quanto seus pontos atuais contribuem para compreender os Jogos Olímpicos de Tóquio. Ademais, a vacinação dos atletas brasileiros, olímpicos e paralímpicos, não somente beneficia os mesmos, mas atinge toda a sociedade brasileira, e por consequência, atinge o Olimpismo. A Pandemia da COVID-19 abarcou gritantes complicações em diversos eventos, entre eles os Jogos Olímpicos, os quais pelo tamanho da sua escala, necessitam de uma análise mais profunda, ao que pese o avanço da vacinação e as diferenças entre as nações participantes dos Jogos, demonstrando a atualidade do tema no Direito Desportivo conjuntamente com o Direito Internacional.