bluuebunny/crossref_metadata_2025 huggingface dataset:
Second-Order Damped Differential Equations with Superlinear Neutral Term: New Criteria for Oscillation
Authors: Al-Jaser Asma , Cesarano Clemente , Qaraad Belgees , Iambor Loredana Florentina
Published: April 2024

This paper focuses on establishing new criteria to guarantee the oscillation of solutions for second-order differential equations with a superlinear and a damping term. New sufficient conditions are presented, aimed at analysing the oscillatory properties of the solutions to the equation under study. To prove these results, we employed various analysis methods, establishing new relationships to address certain problems that have hindered previous research. Consequently, by applying the principles of comparison and the Riccati transformation, we obtained findings that develop and complement those reported in earlier literature. The significance of our results is illustrated with several examples.
Corinthian Currants Promote the Expression of Paraoxonase-1 and Enhance the Antioxidant Status in Serum and Brain of 5xFAD Mouse Model of Alzheimer’s Disease
Authors: Lymperopoulos Dimitris , Dedemadi Anastasia-Georgia , Voulgari Maria-Lydia , Georgiou Eirini , Dafnis Ioannis , Mountaki Christina , Panagopoulou Eirini A. , Karvelas Michalis , Chiou Antonia , Karathanos Vaios T. , Chroni Angeliki
Published: April 2024

Paraoxonase-1 (PON1), a serum antioxidant enzyme, has been implicated in Alzheimer’s disease (AD) pathogenesis that involves early oxidative damage. Corinthian currants and their components have been shown to display antioxidant and other neuroprotective effects in AD. We evaluated the effect of a Corinthian currant paste-supplemented diet (CurD), provided to 1-month-old 5xFAD mice for 1, 3, and 6 months, on PON1 activity and levels of oxidation markers in serum and the brain of mice as compared to a control diet (ConD) or glucose/fructose-matched diet (GFD). Administration of CurD for 1 month increased PON1 activity and decreased oxidized lipid levels in serum compared to ConD and GFD. Longer-term administration of CurD did not, however, affect serum PON1 activity and oxidized lipid levels. Furthermore, CurD administered for 1 and 3 months, but not for 6 months, increased PON1 activity and decreased free radical levels in the cortex of mice compared to ConD and GFD. To probe the mechanism for the increased PON1 activity in mice, we studied the effect of Corinthian currant polar phenolic extract on PON1 activity secreted by Huh-7 hepatocytes or HEK293 cells transfected with a PON1-expressing plasmid. Incubation of cells with the extract led to a dose-dependent increase of secreted PON1 activity, which was attributed to increased cellular PON1 expression. Collectively, our findings suggest that phenolics in Corinthian currants can increase the hepatic expression and activity of antioxidant enzyme PON1 and that a Corinthian currant-supplemented diet during the early stages of AD in mice reduces brain oxidative stress.
Evaluation of Myo-Intimal Media Thickness and Atheromatous Plaques in People Living with HIV from the Archiprevaleat Cohort vs. HIV-Negative Subjects
Authors: Martini Salvatore , Ricci Elena Delfina , Masiello Addolorata , Zacà Sergio , Celesia Benedetto Maurizio , Ferrara Sergio , Di Filippo Giovanni , Tartaglia Alessandra , Basile Rosa , Angiletta Domenico , Maggi Paolo
Published: April 2024

Background: Antiretroviral therapy has allowed a clear improvement in prognosis for HIV patients, but metabolic problems, such as dyslipidemia, remain. This can lead to the development of atheromatous plaques. Our study aims to evaluate whether HIV-positive (HIV+) patients show higher myo-intimal media thickness (IMT) and atheromatous plaques compared to HIV-negative (HIV−) patients. Methods: To evaluate the association between HIV infection in experienced patients and vascular pathology, we performed a cross-sectional study, observing 1006 patients, 380 HIV+ enrolled in the Archiprevaleat cohort, and 626 HIV− as a control group. All patients underwent a Doppler scan of the supra-aortic vessels. We compared the prevalence of IMT > 1.0 mm and plaques in the two groups. Results: Patients in the HIV+ group were younger than those in the HIV− group, with a lower prevalence of hypertension and diabetes and higher dyslipidemia. The prevalence of plaques in strata of age was higher in the HIV+ group than in the HIV− group and was associated with the length of ART exposure. Conclusions: Our cross-sectional, retrospective study shows that HIV+ experienced patients are at greater risk of IMT and atheromatous plaques compared to HIV−. The risk is associated with being HIV+ and with the length of ART exposure. This finding may be useful in preventing cardiovascular risk.
A Methodological Approach to Extracting Patterns of Service Utilization from a Cross-Continuum High Dimensional Healthcare Dataset to Support Care Delivery Optimization for Patients with Complex Problems
Authors: Bambi Jonas , Santoso Yudi , Sadri Hanieh , Moselle Ken , Rudnick Abraham , Robertson Stan , Chang Ernie , Kuo Alex , Howie Joseph , Dong Gracia Yunruo , Olobatuyi Kehinde , Hajiabadi Mahdi , Richardson Ashlin
Published: April 2024

Background: Optimizing care for patients with complex problems entails the integration of clinically appropriate problem-specific clinical protocols, and the optimization of service-system-encompassing clinical pathways. However, alignment of service system operations with Clinical Practice Guidelines (CPGs) is far more challenging than the time-bounded alignment of procedures with protocols. This is due to the challenge of identifying longitudinal patterns of service utilization in the cross-continuum data to assess adherence to the CPGs. Method: This paper proposes a new methodology for identifying patients’ patterns of service utilization (PSUs) within sparse high-dimensional cross-continuum health datasets using graph community detection. Result: The result has shown that by using iterative graph community detections, and graph metrics combined with input from clinical and operational subject matter experts, it is possible to extract meaningful functionally integrated PSUs. Conclusions: This introduces the possibility of influencing the reorganization of some services to provide better care for patients with complex problems. Additionally, this introduces a novel analytical framework relying on patients’ service pathways as a foundation to generate the basic entities required to evaluate conformance of interventions to cohort-specific clinical practice guidelines, which will be further explored in our future research.
Search for Entanglement between Spatially Separated Living Systems: Experiment Design, Results, and Lessons Learned
Authors: Fields Chris , Cohen Lorenzo , Cusimano Andrew , Chakraborty Sharmistha , Nguyen Phuong , Deng Defeng , Iqbal Shafaqmuhammad , Nelson Monica , Wei Daoyan , Delorme Arnaud , Yang Peiying
Published: April 2024

Statistically significant violations of the Clauser–Horne–Shimony–Holt (CHSH) inequality are the “gold standard” test for quantum entanglement between spatially separated systems. Here, we report an experimental design that implements a CHSH test between bioelectric state variables for a human subject and bioelectric and/or biochemical state variables for cultured human cells in vitro. While we were unable to obtain evidence for entanglement with this design, observing only classical correlation, we report lessons learned and suggest possible avenues for future studies.
Enhancing Glucose Biosensing with Graphene Oxide and Ferrocene-Modified Linear Poly(ethylenimine)
Authors: Monkrathok Jirawan , Janphuang Pattanaphong , Suphachiaraphan Somphong , Kampaengsri Sastiya , Kamkaew Anyanee , Chansaenpak Kantapat , Lisnund Sireerat , Blay Vincent , Pinyou Piyanut
Published: April 2024

We designed and optimized a glucose biosensor system based on a screen-printed electrode modified with the NAD-GDH enzyme. To enhance the electroactive surface area and improve the electron transfer efficiency, we introduced graphene oxide (GO) and ferrocene-modified linear poly(ethylenimine) (LPEI-Fc) onto the biosensor surface. This strategic modification exploits the electrostatic interaction between graphene oxide, which possesses a negative charge, and LPEI-Fc, which is positively charged. This interaction results in increased catalytic current during glucose oxidation and helps improve the overall glucose detection sensitivity by amperometry. We integrated the developed glucose sensor into a flow injection (FI) system. This integration facilitates a swift and reproducible detection of glucose, and it also mitigates the risk of contamination during the analyses. The incorporation of an FI system improves the efficiency of the biosensor, ensuring precise and reliable results in a short time. The proposed sensor was operated at a constant applied potential of 0.35 V. After optimizing the system, a linear calibration curve was obtained for the concentration range of 1.0–40 mM (R2 = 0.986). The FI system was successfully applied to determine the glucose content of a commercial sports drink.
Construed Organizational Ethical Climate and Whistleblowing Behavior: The Moderated Mediation Effect of Person–Organization Value Congruence and Ethical Leader Behavior
Authors: Cai Han , Zhu Lingfeng , Jin Xiu
Published: April 2024

An organizational ethical climate enhances the degree of collaboration and cohesion among employees and facilitates the development and interests of organizations. Such roles lead to organizational sustainable development and survival. Therefore, the importance of ethical climate in organizations is becoming increasingly apparent. In this background, this study aims to explore whether an organizational ethical climate can improve whistleblowing behavior and the mediating role of organizational identification in promoting whistleblowing behavior. Most previous studies have only focused on the mediating or moderating role of the model. This study expands the research field, adds the dual moderation of person–organization value congruence and leader ethical behavior, and verifies two moderated mediation models. Overall, the purpose of this study is to determine the behavior of employees under the influence of an organizational ethical climate and, on this basis, propose suggestions for strengthening organizational ethical climate, expanding the scope of research on organizational climate and providing a theoretical basis for related research. In order to achieve the research goals, the data were collected from 344 Chinese SMEs for empirical analysis. The results showed that an organizational ethical climate has no direct impact on whistleblowing behavior but could have a positive effect on whistleblowing formation through the mediating variable of organizational identification. In addition, person–organization value congruence and leader ethical behavior significantly moderated the mediating role of organizational identification between organizational ethical climate and whistleblowing behavior. Finally, the directions that can contribute to future research were suggested.
Design and Performance Assessment of Base Isolated Structures Supplemented with Vibration Control Systems
Authors: Sapountzakis Evangelos , Florakis Georgios , Kapasakalis Konstantinos
Published: April 2024

This paper investigates the implementation of supplemental vibration control systems (VCS) in base isolated (BI) structures, to improve their dynamic performance. More specifically, the aim of the VCS is to reduce the base displacement demand of BI structures, and at the same time mitigate the superstructure seismic responses. The purpose of the examined VCS is dual, and for this reason a multi-objective optimization methodology is formulated for the design of the VCS. The examined vibration absorbers include modifications of the KDamper concept. The KDamper is an extension of the traditional Tuned Mass Damper (TMD), and introduces a negative stiffness (NS) element to the additional oscillating mass of the TMD. The generated NS force is exactly in phase with the inertia force of the added mass, thus, artificially amplifying it. This way, lighter configurations are possible with an enhanced damping behavior. These VCS are designed based on engineering criteria and manufacturing constraints, while the excitation input used in the multi-objective optimization procedure is selected from a dataset of artificial accelerograms, designed to be spectrum-compatible with the EC8 design acceleration response spectrum. The effectiveness of the examined VCS is also assess with real near-fault earthquake records, and a comparison is performed with TMD-based VCS having 50 times larger additional masses. The numerical results demonstrate the superiority of the KDamper-based VCS in improving the dynamic behavior of BI structures over other mass-related systems (TMD).
Exploring the Impact of Accessibility on Place Attachment in Urban Public Open Spaces: A Case Study of Jiamusi City, China
Authors: Zhang Jun , Zhang Zixuan , Liang Yimeng
Published: April 2024

Urban public open spaces are crucial for residents’ well-being, yet accessibility issues persist, affecting activities and social interactions. To this end, we take the main urban area of Jiamusi City, the most northeastern city in China, as an example. We start by examining both spatial and perceptual dimensions, using the Gaussian two-step moving search method to measure spatial accessibility, combining online data with multi-source data from questionnaires. Furthermore, we utilize structural equation modeling to explore the impact of accessibility on place attachment within urban public open spaces. The results show that (1) accessibility has a positive effect on place attachment, while place satisfaction plays a mediating role. (2) There were significant differences in spatial accessibility across modes of travel. Car travel had the best spatial accessibility, followed by bicycle, and walking had the lowest spatial accessibility. (3) Perceived accessibility and spatial accessibility differ, but perceived accessibility it is more persuasive in explaining and illustrating place attachment. Reducing travel costs and meeting the user needs will effectively increase place attachment and place identity. (4) Social factors such as age, education, and residency length also affect accessibility, satisfaction, and attachment. By understanding the impact of accessibility on place attachment, this study helps urban planners to better design urban spatial layout and transportation networks. It enhances people’s attachment to specific places by improving the convenience of traveling, promotes sustainable urban development, and enriches the discourse on the enhancement of psychological motivation in urban public open spaces.
Urban Landscape Perception Research Based on the ERP Method: A Case Study of Jingdezhen, China
Authors: Cheng Yue , Chen Jiayin , Tang Jiajia , Xu Wenbo , Lv Dong , Xiao Xuan
Published: April 2024

Within the rapidly growing urban tourism industry, the development of urban landscapes plays a crucial role in shaping a city’s image and competitiveness; however, standardized and mismatched landscapes often have a negative impact, highlighting the importance of assessing urban landscape perceptions. Although existing studies have discussed this through subjective questionnaires and physiological methods, the underlying neural mechanisms have not been thoroughly explored. The research focuses on Jingdezhen, a renowned historical and cultural city in China, as its case study. Utilized the event-related potential (ERP) method to explore individuals’ perceptual consistency and neural activity toward different types of urban landscapes. We adopted a 2 (landscape type: historical, modern) X 2 (perceptual match: consistent, inconsistent) within-subject design while recording behavioral data and electrophysiological responses. The results showed that, under any condition, there were no significant differences in people’s behavioral data. Neurophysiological results indicate that consistent perceptions of modern landscapes elicited greater P200 responses, suggesting increased attention driven by visual aesthetics and emotional activation. Under conditions of perceptual inconsistency, historical landscapes elicited higher N400 amplitudes than modern landscapes, revealing cognitive conflict and effort. This study demonstrates that P200 and N400 components are effective indicators for assessing urban perception, proving the viability of the event-related potential method in urban landscape research. Additionally, the research reveals the neural mechanisms of urban environmental perception from the early stages of attention and emotional distribution to the later stages of cognitive decision-making, which involve cognitive processes from “bottom-up” to “top-down”. This study not only provides a reference for efficient design planning for those involved in urban science but also inspires the coordination between the developmental needs of historical and modern urban landscapes. Moreover, it offers a new perspective for an interdisciplinary approach to urban perception assessment.
The Role of Chemical Activation in Strengthening Iron Ore Tailings Supplementary Cementitious Materials
Authors: Hu Zhihang , Gu Xiaowei , Cheng Baojun , Wang Qing , Liu Jianping , Ge Xiaowei , Yin Shiqi
Published: April 2024

The preparation of iron ore tailings (IOTs) into supplementary cementitious materials (SCMs) is an effective approach to achieve value-added utilization of industrial solid waste. This study systematically investigates the hydration pattern and strength development of Portland cement systems with the incorporation of IOTs, steel slag (SS), granulated blast-furnace slag (GBFS), and fly ash (FA) under the action of different chemical additives. The hydration products, and microstructure and pore structure of the SCMs are analyzed using X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, and mercury intrusion porosimetry. The findings of this study demonstrate that chemical activation plays a significant role in the strength development of SCMs. Among the five chemical activators tested, Triethanolamine (TEA) had the greatest influence on mechanical properties. The maximum compressive strength of the SCMs at 28 days was 42.9 MPa at a dosage of 1%. Specifically, the addition of TEA promotes volcanic ash reactions, and the high fineness of SCM provides nucleation sites for hydration products. Interactions between the volcanic ash reaction and the complexation reaction of TEA have a positive effect on compressive strength development. This research expands the potential for IOTs SCMs through chemical activation methods for value-added applications.
Workflow for Window Composition Detection to Aid Energy-Efficient Renovation in Low-Income Housing in Korea
Authors: Lee Jong-Won
Published: April 2024

Enhancing the efficiency of windows is important for improving the energy efficiency of buildings. The Korean government has performed numerous building renovation projects to reduce greenhouse gas emissions and mitigate energy poverty. To reduce the costs and manpower requirements of conventional field surveys, this study presents a deep-learning model to examine the insulation performance of windows using photographs taken in low-income housing. A smartphone application using crowdsourcing was developed for data collection. The insulation performance of windows was determined based on U-value, derived considering the frame-material type, number of panes, and area of windows. An image-labeling tool was designed to identify and annotate window components within photographs. Furthermore, software utilizing open-source computer vision was developed to estimate the window area. After training on a dataset with ResNet and EfficientNet, an accuracy of approximately 80% was achieved. Thus, this study introduces a novel workflow to evaluate the insulation performance of windows, which can support the energy-efficient renovation of low-income housing.
Claim Management and Dispute Resolution in the Construction Industry: Current Research Trends Using Novel Technologies
Authors: Kalogeraki Marianna , Antoniou Fani
Published: April 2024

In the Architecture, Engineering and Construction (AEC) industry claims arise frequently, often resulting in disputes. Claim management should be efficient to prevent claims from escalating into disputes, and if disputes are still unavoidable, they should be resolved without delay for the construction process to resume. First, by conducting a bibliometric review, this paper attempts to investigate the literature on construction claims and dispute resolution practices by employing the Scopus database and VOSviewer to retrieve and analyze related sources. The overall trend of research by country, source, and authors is detected, and the emergence of novel technologies such as BIM, blockchain, and smart contracts appearing after 2020 concerning the investigation into construction claim management and dispute resolution was identified. Second, a content analysis on the most recent publications published between 2020 and 2022 was undertaken, indicating six main research themes that represent current research trends. The employment of novel technologies to enhance claim management and dispute resolution practices in the AEC sector is identified, as well. Finally, in order to assist construction professionals and researchers in their work to address construction claims and disputes more efficiently, potential research directions are proposed.
Concise Historic Overview of Rail Corrugation Studies: From Formation Mechanisms to Detection Methods
Authors: Wang Qi-Ang , Huang Xin-Yu , Wang Jun-Fang , Ni Yi-Qing , Ran Sheng-Cai , Li Jian-Peng , Zhang Jia
Published: April 2024

Rail corrugation is a serious problem in a railway transportation system, aggravating the operational risk and shortening the lifetime of train–track system. In order to ensure the safety and reliability of the railway system, the detection of rail corrugation is very important. Thus, this study systematically summarizes the recent research progress of rail corrugation. First, this study introduces the definition of rail corrugation and the classification criteria. Then, the formation mechanism of rail corrugation is analyzed in detail, and its adverse consequences are investigated. Further, this study summarizes several main detection methods, which are corrugation-detection methods based on acceleration measurements, wavelet transform methods for corrugation evaluation, computer-vision-based methods for corrugation automatic detection, digital filtering algorithms for rail corrugation detection, and others. In this study, the formation mechanism and detection methods of rail corrugation are systematically described, and various corrugation-detection methods are also introduced in detail. This study not only provides a scientific basis for railway maintenance, but also lays a solid foundation for future experimental design and data analysis. This study can also guide engineering practice to improve the reliability and safety of railway systems. It also provides useful experience for future railway-engineering design and planning, as well as safer and more reliable operation. In general, this study can provide technical support for the detection of rail corrugation to ensure the safety of the rail–track system.
Research on Relative Humidity and Energy Savings for Air-Conditioned Spaces without Humidity Control When Adopting Air-to-Air Total Heat Exchangers in Winter
Authors: Dong Ming , Zhang Jialiang , Zhang Liufeng , Liu Lianbo , Zhang Xingqiang
Published: April 2024

In view of the problem that the exchange effectiveness is calculated according to a fixed value or only considering the influence of outdoor air parameters when analyzing the suitability of total heat recovery for plate heat recovery equipment in air-conditioned spaces without humidity control, the indoor humidity calculation model and moisture balance equation were established in this research to predict relative indoor humidity. Moreover, the relationship between total heat recovery, effective heat recovery, and the reduction in outdoor air heating load was analyzed using a psychrometric chart of the outdoor air treatment process. Referring to the standard for weather data of building energy efficiency in the Ningbo region, 6 typical days were taken as the calculation conditions. The moisture balance differential equation was solved using MATLAB software to obtain numerical solutions for the hourly indoor air humidity ratio, relative humidity, exchange effectiveness, and effective heat recovery when adopting an air-to-air total heat exchanger in an air-conditioned room of an office, classroom, or commercial building in the winter. The results indicate that, under the calculation conditions, the relative indoor humidity of commercial buildings is relatively high, making it unsuitable for a total heat exchanger. The relative humidity of indoor air in offices and classrooms can be maintained above 30%, and the total exchange effectiveness of a total heat exchanger is between 45% and 100%. The effective total heat recovery was calculated as sensible heat recovery under most calculation conditions.
An Efficient Photocatalytic Oxygen Evolution System with the Coupling of Polyoxometalates with Bismuth Vanadate
Authors: Ong Boon Chong , Lim Teik-Thye , Xue Can , Dong Zhili
Published: April 2024

In this work, a coupling system consisting of bismuth vanadate (BiVO4) and cobalt-based polyoxometalates (Co-POMs) was developed to enhance the oxygen evolution reaction. Crystallization-driven self-assembly and the wet chemical synthesis method were deployed in synthesizing Co-POMs and monoclinic–tetragonal mixed–phase BiVO4, respectively. The introduction of Co-POMs into a BiVO4-containing mixture significantly enhanced the water oxidation reaction, with a more than twofold increment in the total amount of oxygen evolved. For instance, 461.2 µmol of oxygen was evolved from the system containing 20 mg of Co-POMs compared to 195 µmol of oxygen produced from a pristine BiVO4 system. This extraordinary improvement in the oxygen evolution reaction indicates the existence of a positive synergic effect between BiVO4 and Co-POMs, in which Co-POMs could act as effective cocatalysts to extract photogenerated charge carriers generated by BiVO4 and improve the charge transfer process. However, the amount of oxygen produced was slightly reduced to 440.7 µmol with an increase in AgNO3 loading from 30 mg to 60 mg. This unforeseen phenomenon could be elucidated by the shielding effect of silver particles, in which a higher AgNO3 loading led to a more prominent shielding effect. The presence of silver nanoparticles on post-reaction BiVO4 was confirmed by TEM and XPS analysis. This newly established process scheme provides an insight into the development of an efficient photocatalytic oxygen evolution system in realizing future commercial applications toward green energy production.
Introduction and Advancements in Room-Temperature Ferromagnetic Metal Oxide Semiconductors for Enhanced Photocatalytic Performance
Authors: Sundaram Ganeshraja Ayyakannu , Muniyandi Govinda raj , Ethiraj Jayashree , Parimelazhagan Vairavel , Kumar Alagarsamy Santhana Krishna
Published: April 2024

Recent advancements in the field of room-temperature ferromagnetic metal oxide semiconductors (RTFMOS) have revealed their promising potential for enhancing photocatalytic performance. This review delves into the combined investigation of the photocatalytic and ferromagnetic properties at room temperature, with a particular focus on metal oxides like TiO2, which have emerged as pivotal materials in the fields of magnetism and environmental remediation. Despite extensive research efforts, the precise mechanism governing the interplay between ferromagnetism and photocatalysis in these materials remains only partially understood. Several crucial factors contributing to magnetism, such as oxygen vacancies and various metal dopants, have been identified. Numerous studies have highlighted the significant role of these factors in driving room-temperature ferromagnetism and photocatalytic activity in wide-bandgap metal oxides. However, establishing a direct correlation between magnetism, oxygen vacancies, dopant concentration, and photocatalysis has posed significant challenges. These RTFMOS hold immense potential to significantly boost photocatalytic efficiency, offering promising solutions for diverse environmental- and energy-related applications, including water purification, air pollution control, and solar energy conversion. This review aims to offer a comprehensive overview of recent advancements in understanding the magnetism and photocatalytic behavior of metal oxides. By synthesizing the latest findings, this study sheds light on the considerable promise of RTFMOS as effective photocatalysts, thus contributing to advancements in environmental remediation and related fields.
In-Site Growth of Efficient NiFeOOH/NiFe-LDH Electrodes: A Streamlined One-Step Methodology
Authors: Ning Jing , Xu Li , Xu Wei , Li Guizhen , Zhang Wen
Published: April 2024

Oxygen evolution reactions (OER) are often the decisive step in determining the water electrolysis rate. The first row of transition metals and their derivatives, represented by Ni and Fe, have attracted much attention due to their excellent OER performance. Here, we develop a one-step strategy for preparing oxygen-evolving electrodes, in which the NiFeOOH-modified NiFe layered double hydroxide (NiFe-LDH) nanosheet is supported by nickel foam. At 100 mA·cm−2, the overpotential of NiFeOOH-NiFe-LDH was just 227 mV, and the duration times were over 200 h in 1 mol·L−1 KOH. Furthermore, the co-existence of LDH and hydroxyl oxides helps the oxygen evolution reaction. These results suggest the potential for this synthesis strategy to provide a low-cost, highly active OER electrocatalyst for industrial water splitting.
Impact and Implementation of an Early Years Fundamental Motor Skills Intervention for Children 4–5 Years
Authors: Roscoe Clare M. P. , Taylor Nicola , Weir Natalie , Flynn Robert John. , Pringle Andy
Published: April 2024

Fundamental motor skills (FMS) are the cornerstone of a child’s motor development, but concerns remain on the current level of FMS competencies, and intervention is required. This evaluation investigated if a targeted Early Years FMS intervention, delivered by a specialist physical education (PE) provider, improved the FMS of 4–5-year-old children across multiple sites. Methods: The Early Years FMS intervention ran for 18 weeks, 1 h/week, using a standardised programme of activities to develop FMS competencies across 219 children from 15 schools in the Midlands, UK. An adapted assessment was employed as a measure of FMS, assessing locomotor, object control, and stability skills at weeks 1, 9, and 18. The FMS were each rated as green = competent, amber = working towards, or red = not meeting the standards of the skill. A description of key programme implementation characteristics was described. Findings: Statistically significant increases in FMS competencies were achieved for 80% of participants at 18 weeks. Key implementation characteristics for the intervention included consistent staffing, a standardised programme, and a variety of pedagogical approaches delivered by specialist PE staff. Conclusion: This evaluation provided important insights into the effectiveness and implementation of the Early Years FMS intervention to improve FMS competencies in children aged 4–5 years.
Preformed Elastodontic Appliances: Awareness and Attitude of Orthodontists and General Dental Practitioners
Authors: Cannatà Davide , Galdi Marzio , Martina Stefano , Rongo Roberto , D’Antò Vincenzo , Valletta Rosa , Bucci Rosaria
Published: April 2024

Background: Preformed elastodontic appliances (EAs) have been described as safe, cost-effective, and easy-to-use devices for interceptive orthodontic treatment in growing patients. This study aimed to assess the knowledge and the attitude of dentists toward the use of EAs and to compare the behaviors of orthodontists (Os) with those of general dental practitioners (GDPs). Methods: An anonymous survey was distributed among dentists through social media. Twenty-two items were divided as follows: characteristics of respondents; general knowledge about EAs; section for EA-users; and section for EA non-users. Chi-squared tests were used to analyze differences in responses between groups. Results: Participants included 226 Os and 168 GDPs. The majority in both groups reported having adequate knowledge about EAs and utilizing them in their practice. GDPs usually use EAs to treat children during the early phase of growth, while Os also use EAs to address orthodontic problems in different stages of dentition, experiencing a chair time reduction compared with traditional appliances. Regarding EA non-users, GDPs seem not to find an application among their patients, whereas Os reported not having enough patient compliance during treatment. Conclusions: Although treatment with EAs is common among all dentists, differences exist between Os and GDPs in the awareness and application, as well as in the reasons provided for not using EAs.
Frankincense (Boswellia serrata) Extract Effects on Growth and Biofilm Formation of Porphyromonas gingivalis, and Its Intracellular Infection in Human Gingival Epithelial Cells
Authors: Vang David , Moreira-Souza Aline Cristina Abreu , Zusman Nicholas , Moncada German , Matshik Dakafay Harmony , Asadi Homer , Ojcius David M. , Almeida-da-Silva Cassio Luiz Coutinho
Published: April 2024

Frankincense is produced by Boswellia trees, which can be found throughout the Middle East and parts of Africa and Asia. Boswellia serrata extract has been shown to have anti-cancer, anti-inflammatory, and antimicrobial effects. Periodontitis is an oral chronic inflammatory disease that affects nearly half of the US population. We investigated the antimicrobial effects of B. serrata extract on two oral pathogens associated with periodontitis. Using the minimum inhibitory concentration and crystal violet staining methods, we demonstrated that Porphyromonas gingivalis growth and biofilm formation were impaired by treatment with B. serrata extracts. However, the effects on Fusobacterium nucleatum growth and biofilm formation were not significant. Using quantification of colony-forming units and microscopy techniques, we also showed that concentrations of B. serrata that were not toxic for host cells decreased intracellular P. gingivalis infection in human gingival epithelial cells. Our results show antimicrobial activity of a natural product extracted from Boswellia trees (B. serrata) against periodontopathogens. Thus, B. serrata has the potential for preventing and/or treating periodontal diseases. Future studies will identify the molecular components of B. serrata extracts responsible for the beneficial effects.
Synthesis and Characterization of Iron-Doped TiO2 Nanotubes (Fe/TiNTs) with Photocatalytic Activity
Authors: Qattali S. Mohd. Yonos , Nasir Jamal , Pritzel Christian , Kowald Torsten , Sakalli Yilmaz , Moni S. M. Fuad Kabir , Schmedt auf der Günne Jörn , Wickleder Claudia , Trettin Reinhard H. F. , Killian Manuela S.
Published: April 2024

One of the most significant global challenges for humans is environmental pollution. The technology to control this problem is the utilization of semiconductors as photocatalysts. In the current study, iron-doped titania nanotubes (Fe/TiNTs) with increased photocatalytic effect were synthesized via a modified hydrothermal method. The products were characterized by X-ray powder diffraction, scanning electron microscopy, transmission electron microscopy (TEM), gas adsorption, electron spin resonance (ESR) and UV–Vis diffuse reflectance spectroscopy (DRS). TEM results indicated that Fe/TiNTs have a tubular and uniform structure with an average outer diameter of 23–48 nm and length of 10–15 µm. ESR and DRS revealed that Fe3+ ions were successfully introduced into the TiNT structure by replacing Ti4+ ions. An enhanced light absorption in the range of 400–600 nm additionally indicated successful doping. The band gap was narrowed as iron wt% was increased. The photocatalytic activity was evaluated by the degradation of methyl orange (MO) in the presence of Fe/TiNTs and TiTNs by monitoring the degradation of MO under UV light irradiation. An acceleration on the hydration of Portland cement was observed in the presence of 2.0 wt% Fe/TiNTs. Fe/TiNTs can be used as a nanomaterial in cement-based building materials to provide self-cleaning properties to the surface of concrete even in indoor environments.
Successful Multimodal Treatment of Intracranial Growing Teratoma Syndrome with Malignant Features
Authors: Satake Daiken , Natsumeda Manabu , Satomi Kaishi , Tada Mari , Sato Taro , Okubo Noritaka , Kawabe Keita , Takahashi Haruhiko , Tsukamoto Yoshihiro , Okada Masayasu , Sano Masakazu , Iwabuchi Haruko , Shibata Nao , Imamura Masaru , Imai Chihaya , Takami Hirokazu , Ichimura Koichi , Nishikawa Ryo , Umezu Hajime , Kakita Akiyoshi , Oishi Makoto
Published: April 2024

Molecular analysis of the growing teratoma syndrome has not been extensively studied. Here, we report a 14-year-old boy with a growing mass during treatment for a mixed germ cell tumor of the pineal region. Tumor markers were negative; thus, growing teratoma syndrome was suspected. A radical resection via the occipital transtentorial approach was performed, and histopathological examination revealed a teratoma with malignant features. Methylation classifier analysis confirmed the diagnosis of teratoma, and DMRT1 loss and 12p gain were identified by copy number variation analysis, potentially elucidating the cause of growth and malignant transformation of the teratoma. The patient remains in remission after intense chemoradiation treatment as a high-risk germ cell tumor.
Quantitative Microvascular Change Analysis Using a Semi-Automated Algorithm in Macula-on Rhegmatogenous Retinal Detachment Assessed by Swept-Source Optical Coherence Tomography Angiography
Authors: Díaz-Aljaro Pablo , Valldeperas Xavier , Broc-Iturralde Laura , Romanic-Bubalo Nevena , Díaz-Aljaro Ignacio , Chu Zhongdi , Wang Ruikang K. , Zarranz-Ventura Javier
Published: April 2024

Purpose: The purpose of this study was to objectively evaluate the longitudinal changes observed in the retinal capillaries in eyes with macula-on rhegmatogenous retinal detachment (RRD), assessed with optical coherence tomography angiography (OCTA), and to assess the role of these microvascular measures as potential biomarkers of postoperative visual outcomes. Methods: This was a prospective, longitudinal study conducted on consecutive patients who underwent 25 G pars plana vitrectomy for primary RRD. The vessel area density (VAD), vessel skeleton density (VSD), and vessel diameter index (VDI) were assessed in the superficial (SCP) and deep (DCP) capillary plexuses. Results: Twenty-three eyes with macula-on RRD were included in the study. The mean preoperative VDI, VAD, and VSD of the RRD eye were 18.6 ± 1.1, 0.43 ± 0.02, and 0.17 ± 0.01 in the SCP; and 18.6 ± 0.6, 0.38 ± 0.03, and 0.15 ± 0.01 in the DCP, respectively. At month 6, eight (34.8%) eyes achieved a best-corrected visual acuity (BCVA) gain ≥ 0.1 LogMAR. A preoperative VDI > 17.80, VSD > 0.170, and VDI-change > −0.395 in the SCP; and VDI > 18.11 and VDI change > −0.039 in the DCP were predictors of achieving a BCVA-gain ≥ 0.1 LogMAR. Conclusions: The preoperative VDI in SCP and DCP, the preoperative VSD in SCP, and their changes from preoperative values were predictors of visual outcomes. A quantitative OCTA analysis of capillary density and morphology may represent a potential predictive tool for surgical outcomes in RRD. The results reported in this study suggest that OCTA is a useful ancillary test for clinical disease management.
Transposon and Transgene Tribulations in Mosquitoes: A Perspective of piRNA Proportions
Authors: Lau Nelson C. , Macias Vanessa M.
Published: April 2024

Mosquitoes, like Drosophila, are dipterans, the order of “true flies” characterized by a single set of two wings. Drosophila are prime model organisms for biomedical research, while mosquito researchers struggle to establish robust molecular biology in these that are arguably the most dangerous vectors of human pathogens. Both insects utilize the RNA interference (RNAi) pathway to generate small RNAs to silence transposons and viruses, yet details are emerging that several RNAi features are unique to each insect family, such as how culicine mosquitoes have evolved extreme genomic feature differences connected to their unique RNAi features. A major technical difference in the molecular genetic studies of these insects is that generating stable transgenic animals are routine in Drosophila but still variable in stability in mosquitoes, despite genomic DNA-editing advances. By comparing and contrasting the differences in the RNAi pathways of Drosophila and mosquitoes, in this review we propose a hypothesis that transgene DNAs are possibly more intensely targeted by mosquito RNAi pathways and chromatin regulatory pathways than in Drosophila. We review the latest findings on mosquito RNAi pathways, which are still much less well understood than in Drosophila, and we speculate that deeper study into how mosquitoes modulate transposons and viruses with Piwi-interacting RNAs (piRNAs) will yield clues to improving transgene DNA expression stability in transgenic mosquitoes.
Land Use Land Cover (LULC) Change Dynamics Associated with Mining Activities in Kitwe District and Adequacy of the Legal Framework on Mine Closure in Zambia
Authors: Mutimba Kawisha , Watanabe Teiji , Chand Mohan Bahadur
Published: April 2024

Land use land cover (LULC) changes resulting from copper exploration in Kitwe District, Copperbelt Province has adversely impacted the environment. To understand LULC change dynamics associated with mining activities, this study mapped LULC changes using the Google Earth Engine (GEE) from 1990 to 2020. In addition, the Zambian legal framework for mine closure was assessed in terms of adequacy and comprehensiveness. A remote sensing analysis using Landsat TM (1990, 2000, and 2010) and OLI (2020) images was performed and the GEE Random Forest classifier algorithm was employed to detect LULC changes. Then, transition matrices and overall changes were calculated for each LULC class. The LULC classification had an overall accuracy and kappa coefficient of 82.47% and 0.78, respectively. In total, 45.2% of the district area (360.92 km2) experienced LULC changes from 1990 to 2020. The overall change indicates that the areas of built-up area, bare land, and grassland/pasture/agricultural land gained 35.84, 14.67, and 43.53 km2, respectively, while forest lost 95.30 km2, with the major driver being the privatization of mining companies. Several concerns regarding the mine closure process practiced in Zambia have principally been raised to the government. Although the legislation generally conformed to international best practices, a gap involving various pieces of legislation, overlapping requirements, and different interpretations of the laws by different governmental departments makes the system complex and unmanageable. An area of concern is the government’s capability and competence to implement legislation. Ineffective law enforcement, that is, the inadequacy of the legislation, is to blame for LULC changes in mining areas, resulting in mining corporations not paying attention to the changes made, particularly regarding mine closures. This study provides decision-makers and land use planners with baseline knowledge on LULC changes that can be valuable for future mining legislation and how these legislations can be effectively executed to ensure sustainable mine closure.
Impact of Gamification on Students’ Learning Outcomes and Academic Performance: A Longitudinal Study Comparing Online, Traditional, and Gamified Learning
Authors: Lampropoulos Georgios , Sidiropoulos Antonis
Published: April 2024

This study aims to examine the influence of gamification in students’ learning outcomes and academic performance. A longitudinal study was conducted to compare students’ academic performance in online learning (2020–2021), traditional learning (2021–2022), and gamified learning (2022–2023). The longitudinal study lasted 3 years and a total of 1001 higher education students were involved. Three research questions were set to be explored and students’ viewpoints and experiences were also examined through a questionnaire of 20 questions. This study follows a quantitative research approach. The data refers to students’ academic performance, success rate, excellence rate, withdrawal rate, engagement, motivation, and perspectives. In the laboratory part of the course, gamified learning yielded better outcomes over online learning and traditional learning in success rate (39% and 13%), excellence rate (130% and 23%), average grade (24% and 11%), and retention rate (42% and 36%) respectively. In the theoretical part of the course, gamified learning resulted in better outcomes over online learning and traditional learning in success rate (19% and 14%), in excellence rate (125% and 79%), and in average grade (25% and 12%) respectively. In the overall course, gamified learning yielded better outcomes over online learning and traditional learning in success rate (14% and 14%), in excellence rate (122% and 70%), and in average grade (25% and 17%) respectively. The highest increase was observed in students’ excellence rate. Students highly regarded gamification as an effective educational approach that can increase their learning outcomes, engagement, productivity, and motivation and trigger both their both intrinsic and extrinsic motivation. The learning experience become more enjoyable and students’ basic needs in terms of autonomy, competence and sufficiency, and relatedness and sense of belonging were met. Traditional learning also resulted in better learning outcomes when compared to online learning. Gamification emerged as an effective learning approach which leads to improved learning outcomes and academic performance, learning motivation, engagement, and retention rate over online learning and traditional learning in both theoretical and applied course settings.
Integration and Assessment of ChatGPT in Medical Case Reporting: A Multifaceted Approach
Authors: Lin Kuan-Chen , Chen Tsung-An , Lin Ming-Hwai , Chen Yu-Chun , Chen Tzeng-Ji
Published: April 2024

ChatGPT, a large language model, has gained significance in medical writing, particularly in case reports that document the course of an illness. This article explores the integration of ChatGPT and how ChatGPT shapes the process, product, and politics of medical writing in the real world. We conducted a bibliometric analysis on case reports utilizing ChatGPT and indexed in PubMed, encompassing publication information. Furthermore, an in-depth analysis was conducted to categorize the applications and limitations of ChatGPT and the publication trend of application categories. A total of 66 case reports utilizing ChatGPT were identified, with a predominant preference for the online version and English input by the authors. The prevalent application categories were information retrieval and content generation. Notably, this trend remained consistent across different months. Within the subset of 32 articles addressing ChatGPT limitations in case report writing, concerns related to inaccuracies and a lack of clinical context were prominently emphasized. This pointed out the important role of clinical thinking and professional expertise, representing the foundational tenets of medical education, while also accentuating the distinction between physicians and generative artificial intelligence.