bluuebunny/crossref_metadata_2025 huggingface dataset:
Doubly robust estimators for generalizing treatment effects on survival outcomes from randomized controlled trials to a target population
Authors: Lee Dasom , Yang Shu , Wang Xiaofei
Published: December 2022

In the presence of heterogeneity between the randomized controlled trial (RCT) participants and the target population, evaluating the treatment effect solely based on the RCT often leads to biased quantification of the real-world treatment effect. To address the problem of lack of generalizability for the treatment effect estimated by the RCT sample, we leverage observational studies with large samples that are representative of the target population. This article concerns evaluating treatment effects on survival outcomes for a target population and considers a broad class of estimands that are functionals of treatment-specific survival functions, including differences in survival probability and restricted mean survival times. Motivated by two intuitive but distinct approaches, i.e., imputation based on survival outcome regression and weighting based on inverse probability of sampling, censoring, and treatment assignment, we propose a semiparametric estimator through the guidance of the efficient influence function. The proposed estimator is doubly robust in the sense that it is consistent for the target population estimands if either the survival model or the weighting model is correctly specified and is locally efficient when both are correct. In addition, as an alternative to parametric estimation, we employ the nonparametric method of sieves for flexible and robust estimation of the nuisance functions and show that the resulting estimator retains the root-

n

n

consistency and efficiency, the so-called rate-double robustness. Simulation studies confirm the theoretical properties of the proposed estimator and show that it outperforms competitors. We apply the proposed method to estimate the effect of adjuvant chemotherapy on survival in patients with early-stage resected non-small cell lung cancer.
Pathological characteristics of liver injury induced by N,N-dimethylformamide: From humans to animal models
Authors: Wu Haicong , Shi Yixian , Yan Yongqin , Zhang Jiaxiang , Zhou Xiaoling , Mei Xuan , Zheng Zhiyong , Li Dongliang
Published: December 2022

N,N-Dimethylformamide (DMF) is widely used in chemical industries because of its excellent solvent properties. Poisoning accidents caused by DMF have been frequently reported, particularly hepatotoxicity; however, the hepatic pathological changes have rarely been described. This study aimed to summarise the pathological characteristics of the hepatotoxicity associated with DMF in clinical cases and to verify in animal models. Liver pathologies of two patients with liver failure due to DMF were retrospectively analysed. Thirty-six rats were categorised into the DMF group (intraperitoneally injected with 4 g/kg DMF once a week), carbon tetrachloride (CCl4) group (intraperitoneally injected with 0.5 g/kg CCl4 twice a week) and control group (intraperitoneally injected with normal saline once a week). The general condition and changes in hepatic pathology at 48 h and 8 weeks were observed. Liver tissues of patients exhibited multiple unevenly distributed inflammatory and fibrotic lesions. The DMF-induced liver injury animal model was successfully established. Inflammation and fibrosis were heterogeneously observed throughout the liver in the DMF group, contrast to entirely homogeneous lesions in the CCl4 group. Specific hepatic pathological findings (heterogeneous lesions) caused by DMF detected for the first time in humans and animal model, may be significant in the clinical diagnosis of DMF poisoning.
Is a Psychic Thermidor Inevitable? Marcuse’s Hedonism and Its Freudian Challenge
Authors: Yinon Dror
Published: December 2022

In this paper I argue that Marcuse’s Eros and Civilization is a revision of his early hedonism presented in his early papers from the 1930’s, a revision necessitated by the challenge Freud’s psychoanalysis posited to the possibility of hedonism. In the first section of the paper, I present Marcuse’s critical hedonist position, mainly in “On Hedonism” (1938), where he develops a social and objective hedonism that should be set as a main political goal of a society. Accordingly, the key to a transformation of society is located at the social-political level. However, Freud’s metapsychology shows that the barriers that prevent a transformation of society are located at a much deeper level and are found in the relation between the psychological structure of individuals and social pressure, between the dynamics of the instincts and society’s material welfare. Thus, the possibility of a society that asserts happiness as its principle depends on the possibility of a transformation of human metapsychology and its social manifestation. This challenge, and the manner in which Marcuse dealt with it is the subject of the second section in which I analyze Eros and Civilization as Marcuse’s rethinking of his hedonism in light of Freud.
Il ricettario della Santissima Annunziata di Firenze
Authors: Urraci Giovanni
Published: December 2022

This paper presents the preliminary results of a study on the untitled and unpublished recipe book transmitted by the codex conv.soppr.F.VIII.1834 (Biblioteca Nazionale Centrale di Firenze), previously conserved in the library of the convent of the Most Holy Annunciation (Florence); the codex contains both culinary recipes and «secrets». We argue that the composition of the manuscript took place in the second half of the seventeenth century (§§2‒3) and was carried out by multiple authors (§4). Subsequently, we analyse its main linguistic features, with particular regard to orthographical instability and morphological variation (§5). Finally, we investigate the main sources of the cookbook (§6), examining in detail some recipes taken from Bartolomeo Scappi’s Opera.
Il cuoco reale e cittadino (1724): un ricettario tradotto e integrato
Authors: Iacolare Salvatore
Published: December 2022

The paper offers an in-depth study of one of the first Italian recipe books translated from a French source: Il Cuoco reale e cittadino, published for the first time in Bologna in 1724. Specifically, a section of the work absent in the French original – the Aggiunta di alcune vivande all’Italiana – is highlighted, in order to determine its features and the relationship to contemporary or seventeenth-century sources. By reconsidering the editorial history of the translated cookbook, the paper is also able to backdate the previously recorded gastronomic Frenchisms in the Italian lexicon through accurate comparison with the secondary literature.
Ricettari regionali e lessico gastronomico napoletano d’età borbonica
Authors: Maggi Andrea
Published: December 2022

The paper aims to present some preliminary outcomes as part of the National Research Project Atlante della lingua e dei testi della cultura gastronomica italiana dall’età medievale all’Unità (AtLiTeG). The project’s main purpose is to reconstruct the history and geography of Italian culinary texts and their language from the medieval period to the Unification of Italy. The Unit of Naples «Federico II» created a corpus of interregional cookbooks printed between the 18th and the 19th centuries, namely before the turning point represented by Pellegrino Artusi’s Scienza in cucina (1891). After illustrating our digital database, together with other kinds of collected sources, we will deal with some historical-linguistic and lexical issues related to the Cuoco galante (1773) by Vincenzo Corrado, a very important gastronome and chef of Bourbon Naples.
Zur Subversion des höfischen Liebesdiskurses: Christine de PizansCent Ballades d’amant et de dame(1409–1410) zwischen Erotik, Misogynie und marienhafter Selbstinszenierung
Authors: Jacobi Claudia
Published: December 2022

This contribution analyses the tension betweenimitatioandrenovatioin Christine de Pizan’sCent Ballades d’amant et de dame(1409–1410). It aims to show that Pizan intertwines traditional courtly discourse with fragments of Jean de Meun’s and Ovid’s writings, in order to denounce the courtly topos of worship of the lady as a manipulative strategy of seduction. In this way, she emphasizes the misogynistic conditions of the sublimated muteness and passivity of women in courtly discourse and engages in meta-reflections on her own role as a writer in the cultural context of theQuerelle des femmesand on the historical decline of France during the reign of Charles VI.
« Mon cors stracoruza » : une note lexicale franco-italienne
Authors: Guariglia Federico
Published: December 2022

The aim of the article is to study the prefixation instra- in the texts of Franco-Italian literature. Starting from the attestation of the wordstracoruzain thechanson de geste Huon d’Auvergne, the analysis will consider other similar derivatives, in order to study the interesting phenomenon ofcode-mixing. The conclusions underline, once again, the lexical and morphological vitality of the French-Italian authors and their works.
It.mosciame‘filetto di tonno essiccato e salatoʼ
Authors: Schweickard Wolfgang
Published: December 2022

The case of It.mosciame‘dry salted tunny fishʼ (< Sp.moxama‘id.ʼ < Ar. mušammaʕ​, participle of the verbšammaʕ​a‘to rub or smear with waxʼ, ‘to dryʼ) underlines once again the complexity of the lexical interrelationship between the Arab world and Europe (as well as the Ottoman empire). The ramifications of the word's history take their origin from Andalusian Arabic, whence it passes into Spanish and Catalan, and finally enters Italian, where it appears for the first time in the translation of Fernão Lopez de Castanheda'sHistóriaby Alfonso Ulloa (died 1570), and subsequently in Spanish-Italian lexicography (Franciosini 1638), in various literary texts (beginning with Aggravi'sAntilucernaof 1664) and in several Italian dialects (with documentation starting from 1714, but surely earlier in oral use).
Development and Efficacy Evaluation of an SP01-adjuvanted Inactivated Escherichia Coli Mutant Vaccine Against Bovine Coliform Mastitis
Authors: Li Xinyu , Tian Chongyu , Han Hui , Shi Bochang , Li Huabin , Liu Yuan , He Wei , Li Chunhe , Li Min , Zheng Yuanqiang , Li Bo , Zhao Liyan , Zheng Naxin , Yan Fang , Zhao Zhongpeng
Published: December 2022

Objective:

Escherichia coli (E. coli) is one of the most common pathogens causing clinical mastitis in cattle, but no vaccine is available to prevent this disease in China. Therefore, development of an E. coli vaccine against bovine clinical mastitis is urgently needed.

Methods:

The candidate vaccine (Ch-O111-1) and challenge (LZ06) strains were screened from milk samples of cows with clinical mastitis. To extend the cross-protection of the Ch-O111-1 strain, we deleted the galE gene fragment of the Ch-O111-1 strain through homologous recombination between the Ch-O111-1 strain and pCVD442/ΔgalE plasmid, which was identified through conventional methods, including PCR, SDS-PAGE and sequencing. The Ch-O111-1/ΔgalE (Z9) strain was characterized by extensive cross-reactivity and attenuated virulence. We prepared inactivated Z9 vaccines with different adjuvants.

Results:

Immunization of inactivated Z9 antigen induced adjuvant-, dosage- and inoculation time-dependent antibody titers in cows and mice. Furthermore, immunization with SP01-adjuvanted inactivated Z9 vaccine protected cows against severe clinical mastitis caused by LZ06 and protected mice against death due to LZ06.

Conclusion:

An SP01-adjuvanted inactivated Z9 vaccine was successfully developed and found to protect cows against severe mastitis caused by Escherichia coli.
Mouse uterine stem cells are affected by endocrine disruption and initiate uteropathies
Authors: Singh Pushpa , Bhartiya Deepa
Published: December 2022

Underlying pathomechanisms leading to initiation of uteropathies including non-receptive endometrium, hyperplasia, adenomyosis, endometriosis, fibroids, and cancer remain elusive. Two populations of stem cells exist in mouse uterus including pluripotent, very small embryonic-like stem cells (VSELs) and ‘progenitors’ endometrial stem cells (EnSCs) which express ERα, ERβ, PR and FSHR, participate in the regular remodelling and maintain life-long homeostasis. The present study aimed to delineate possible stem cell origins for various uteropathies. For this mouse pups were treated with estradiol or diethylstilbestrol and were studied for adult onset of various uteropathies. Treatment resulted in disrupted estrous cycles, reduced uterine weights, and marked hyperplasia in both epithelial and myometrial compartments, and the stromal compartment was also affected. VSELs were increased in numbers as judged by flow cytometry and increased expression of transcripts specific for Oct-4A, Sox-2, and Nanog but their further differentiation into a receptive endometrium was affected. Reduced 5-methyl cytosine expression suggested global hypomethylation and was associated with several oncogenic events including loss of tumor suppressor genes (Pten, p53), dysregulated DNA mismatch repair axis, and repair enzymes. Stem cells were epigenetically altered and showed increased expression of DNMTs, loss of imprinting loci (Igf2-H19, Dlk1-Meg3), and Ezh2. Increased co-expression of CD166 and ALDHA1 with OCT-4 in stem cells was associated with increased Esr-2 and reduced Pr in the endometrium while both were several folds upregulated in the myometrium. Study results suggest that various uteropathies ensue due to the dysfunction of tissue-resident stem cells and provide huge scope for further research.
LA GAMIFICACIÓN COMO ESTRATEGIA METODOLÓGICA PARA ENSEÑAR GRAMÁTICA EN EL CONTEXTO EDUCATIVO UNIVERSITARIO: EXPLORANDO EL USO DE "KAHOOT"
Authors: Martínez Lirola María
Published: December 2022

Este artículo muestra los resultados de un estudio que consistió en la implementación de la herramienta de gamificación Kahoot en una asignatura de inglés como lengua extranjera en la enseñanza universitaria. Los objetivos de este artículo son: 1. Comprobar si promover una enseñanza de la gramática inglesa en la que se integre el uso de la herramienta Kahoot contribuye a motivar al alumnado a aprender y a dotar de dinamismo el estudio de los contenidos gramaticales en la educación superior y 2. Conocer las opiniones del alumnado sobre la implementación de esta herramienta de gamificación para enseñar gramática. El estudio utiliza un diseño de investigación de métodos mixtos (cualitativo y cuantitativo) observando la participación del estudiantado en la enseñanza gramatical gamificada y utilizando un cuestionario al final del cuatrimestre. Los hallazgos muestran que el alumnado valora muy positivamente el uso de Kahoot para revisar los temas de gramática explicados en clase pues permite revisar lo aprendido de una manera lúdica, aplicar la teoría a la práctica de una manera dinámica y revisar los errores de forma gamificada. Las principales conclusiones del estudio indican que Kahoot dinamiza el proceso de enseñanza-aprendizaje y fomenta la motivación y la creatividad del alumnado.
PRESENTACIÓN
Authors: Pernas Morado Eulogio
Published: December 2022

Presentación dos contidos do número 32
Convex Bodies of Constant Width in Spaces of Constant Curvature and the Extremal Area of Reuleaux Triangles
Authors: Böröczky Károly J. , Sagmeister Ádám
Published: December 2022

Extending Blaschke and Lebesgue’s classical result in the Euclidean plane, it has been recently proved in spherical and the hyperbolic cases, as well, that Reuleaux triangles have the minimal area among convex domains of constant width D. We prove an essentially optimal stability version of this statement in each of the three types of surfaces of constant curvature. In addition, we summarize the fundamental properties of convex bodies of constant width in spaces of constant curvature, and provide a characterization in the hyperbolic case in terms of horospheres.
Amor in Vergil: Good or Bad?
Authors: Johnston Patricia A.
Published: December 2022

Vergil interweaves the varying meanings of amor, from not only a positive force, to aggressive desires and to all its varied aspects, making it both harsh, deceptive and cruel, and conversely something very special reflecting things most cherished and respected.
Constitutional identity, a new legal Babel in Europe
Authors: Baudoin Marie-Élisabeth
Published: December 2022

Constitutional identity appears as an increasingly frequent argument in the case law of constitutional courts in Europe. For many authors, it is a way to initiate dialogue with the European Union on equal terms. In this article, we argue that dialogue is not always a source of harmony, because the terms of the interaction are not exactly the same in Luxembourg and in the member states of the European Union. The Court of Justice of the European Union interprets the national identity of the member states in a way that is not always similar to the content given by the States to their constitutional identity. As a consequence, constitutional identity may allow the Member States to strengthen the specificity of their constitutional rules and, in turn, weaken the unity of European constitutionalism. Far from being an Esperanto, constitutional identity rather appears as the new legal Babel in Europe.
Micro-dose, macro-impact: Leveraging psychedelics in frontline healthcare workers during the COVID-19 pandemic
Authors: Atoian Andre , Bowles Harry , Gerhke Sarah , Atoian Suzy , Bowles Nigel , Thangathurai Duraiyah
Published: December 2022

Background and aims

The COVID-19 pandemic exacerbated pre-existing high-levels of physician stress and burnout1. In order to help treat frontline colleagues who were diagnosed with acute stress disorder, we chose a non-psychedelic, ketamine micro-dose treatment strategy for symptom management.

Methods

We provided care virtually, and all patients were prescribed sublingual ketamine once daily. Each patient was evaluated using the NIH-PROMIS CAT assessments for stress, depression, anxiety, and PTSD via a remote, HIPAA compliant patient self-reporting platform. Progress was tracked and assessed against a baseline value obtained prior to the start of treatment. Patient progress was evaluated at a 4–6-week interval. Patients did not report any significant side effects to the treatment regimen.

Results

100% (25/25) of patients experienced improved anxiety, 92% (23/25) experienced improved stress, 96% (24/25) experienced improved PTSD, and 91% (20/22) experienced improved depression.

Conclusions

While we cannot draw definitive conclusions from the association demonstrated by this data, we believe these results demonstrate that further research into the efficacy of daily, short-term ketamine micro-doses for treatment of acute stress disorder is warranted.
Eksplorasi Penangkapan Ikan dengan Pancing Ulur Tuna Madidihang Skala Kecil
Authors: Haruna Haruna , Tupamahu Agustinus , Tawari Ruslan H.S. , Siahainenia S.R. , Trisnadhi Ari , Wamnebo Muhammad Ikhsan
Published: December 2022

Informasi tentang kondisi perikanan tuna skala kecil di beberapa lokasi di Maluku, termasuk di Buru Utara adalah sangat terbatas sehingga perlu untuk dieksplorasi. Penelitian ini bertujuan untuk menganalisis kondisi armada penangkapan, komposisi ukuran hasil tangkapan, CPUE, dan musim penangkapan. Pengumpulan data dilakukan pada bulan Juli sampai September 2019. Data yang dikumpulkan meliputi jumlah armada penangkapan, hasil tangkapan, posisi daerah penangkapan ikan, dan panjang berat ikan. Data sekunder diperoleh dari Yayasan MDPI berupa data Produksi dan hasil tangkapan 5 tahun terakhir di Perairan Buru Utara. Data dianalisis secara deskriptif dan disajikan dalam bentuk gambar dan grafik histogram. Kapal dikonstruksikan dari bahan FPR dan menggunakan mesin motor tempel 15 PK berbahan bakar bensin. Dimensi rata-rata adalah panjang 8,04 m, lebar 1,29 m, tinggi 0.6 m. Daerah operasi penangkapan tuna diperkirakan 5-30 mil dari pangkalan pendaratan, hasil tangkapan didominasi tuna madidihang (71,86%), dan mempunyai ukuran panjang total berkisar antara 21-160 cm. Rata-rata hasil tangkapan adalah 6.782 kg/unit kapal/tahun atau CPUE 56 kg/unit kapal/trip. Musim penangkapan terjadi pada bulan Januari, Mei, Juli, November dan Desember.
Konektivitas Sistem Sosial-Ekologi Lamun dan Perikanan Skala Kecil
Authors: Sidiq Abdullah , Handayani Handayani , Pratomo Hurip
Published: December 2022

Penelitian ini dilaksanakan pada bulan April sampai Mei 2018 di Perairan Pulau Raam, Kota Sorong. Penelitian ini dilakukan dengan pendekatan kualitatif dan kuantitatif. Responden yang dipilih ditunjuk secara permanen sebanyak 15 responden untuk nelayan dari masing-masing Kampung. Hasil identifikasi keanekaragaman hayati menunjukkan bahwa terdapat dua famili lamun, Delapan jenis lamun yang menutupi kawasan tersebut. Lamun yang menutupi area di kedua stasiun tergolong sedang. Cakupan wilayah di kedua wilayah tersebut antara 40 % sampai 50 % yang tergolong “sedang”. Kepadatan jenis di kedua stasiun juga termasuk sedang. Hasil dari penelitian menyebutkan bahwa beberapa nelayan yang ada di Kampung Biak dan Kampung Buton telah memanfaatkan keberadaan dari ekosistem lamun dalam pemenuhan kebutuhannya. Alat tangkap yang digunakan nelayan yang memanfaatkan ekosistem lamun di kampung tersebut antara lain: jaring, pancing, bubu lobster, dan perangkap ikan. Hasil tangkapan terbesar dari perikanan skala kecil di Kampung Biak dengan alat tangkap jaring yaitu ±16,5 kg/ hari, sedangkan di Kampung Buton yaitu dengan alat tangkap perangkap ikan sebesar ±23,1 kg/hari. Beberapa famili yang paling mendominasi hasil tangkapan di kedua kampung tersebut yaitu Siganidae, Scaridae, Lethrinidae, dan Lutjanidae. Hal ini menunjukkan bahwa ekosistem lamun memiliki fungsi ekonomi yang tinggi karena jenis tersebut termasuk spesies target untuk menunjang mata pencaharian nelayan. Hasil analisis pendapatan perikanan skala kecil di ekosistem lamun pada lokasi penelitian menunjukkan bahwa pendapatan yang didapat oleh para nelayan di Kampung Biak dan Buton sebesar Rp 202.124,00 /hari dan 193.151,00 /hari. Hasil tersebut dapat menggambarkan bahwa betapa pentingnya keberadaan ekosistem lamun sehingga dapat dijadikan sebagai tempat penangkapan bagi perikanan skala kecil yang bisa berkontribusi dalam ketahanan pangan dan sebagai mata pencaharian nelayan di kampung tersebut.
Kondisi Biologi Ikan Layang (Decapterus spp) yang Didaratkan di Pemangkat, Kalimantan Barat
Authors: Setya Dona , Susiloningtyas Dewi
Published: December 2022

Perikanan ikan layang di Kalimantan Barat pada umumnya ditangkap dengan alat tangkap purse seine di Laut Natuna Utara. Hasil tangkapan utama yaitu ikan layang dan pendaratan terbesarnya di Pemangkat. Perkembangan produksi ikan layang yang di daratkan di Pemangkat mengalami penurunan yang drastis dari tahun 2011 – 2017 tetapi upaya penangkapannya meningkat. Secara biologis ikan layang yang tertangkap banyak yang belum matang gonad, sehingga kemungkinan gejala terjadinya penangkapan ikan berlebih disebabkan ikan layang yang tertangkap didominasi oleh ikan–ikan yang belum memijah. Hal ini akan mempengaruhi proses recruitment ikan layang di daerah tersebut, maka populasi ikan layang tersebut akan menurun.
Hubungan Panjang Bobot dan Beberapa Aspek Reproduksi Ikan Cakalang (Katsuwonus pelamis Linnaeus, 1758)
Authors: Suyuti DM Yusnan , Wahana Syainullah , Dahliana Besse , Nur Muhammad , Firdhita Alam Nasyrah Adiara
Published: December 2022

Ikan cakalang tergolong sebagai jenis ikan pelagis penting yang bernilai ekonomis tinggi. Tujuan penelitian ini yaitu untuk mengetahui pola pertumbuhan dan berbagai aspek reproduksi ikan cakalang sehingga dijadikan landasan dalam strategi pengelolaan ikan cakalang di Teluk Bone. Pengambilan sampel dimulai pada bulan Juli hingga September 2022 pada lokasi yang merupakan fishing-base nelayan yaitu di Kelurahan Lonrae, Kabupaten Bone, Sulawesi Selatan. Prosedur penelitian meliputi pengambilan sampel secara acak kemudian dimasukkan ke tempat ikan dan dilanjutkan dengan  membawa sampel ke Laboratorium untuk dianalis. Parameter yang diteliti dan metode pada penelitian ini antara lain pola pertumbuhan ikan cakalang yang dianalisis  melalui hubungan panjang bobot, nisbah kelamin dengan analisis “Chi-Square”, dan Indeks kematangan gonad dengan metode Johnson. Hasil penelitian ini, menunjukkan diperoleh koefisien regresi b = 3.481 pada gabungan ikan jantan dan ikan betina, koefisien regresi b = 3.597 khusus pada ikan jantan dan b = 3.419 khusus pada ikan betina. Hasil uji t  terhadap nilab b menunjukkan t hitung >  t tabel sehingga ikan cakalang pada penelitian ini tergolong memiliki pola alometrik positif. Faktor kondisi ikan cakalang betina lebih tinggi dibanding ikan jantan, pada gabungan jantan dan betina diperoleh kisaran 1.12-2.10 (rata-rata 1.39), khusus ikan jantan diperoleh 1.12-2.1  (rata-rata 1.32) dan kisaran 1.19-1.80 (rata-rata 1.50) pada ikan cakalang betina.  Indeks kematangan gonad ikan cakalang diperoleh nilai yang berkisar antara 1.176 – 3.448  pada jantan 1.795 – 4.167 pada ikan betina. Terkait dengan tingkat kematangan gonad yang diamati selama penelitian masih dikategorikan belum matang gonad.
Performa Budidaya Ikan Nila (Oreochromis sp.) pada Sistem Kombinasi Bioflok dan Resirkulasi
Authors: Abidin Zaenal , DH. Setyono Bagus , Santanumurti Muhammad Brotowijoyo
Published: December 2022

Penelitian bertujuan untuk mengetahui performa teknologi budidaya sistem resirkulasi yang dikombinasikan dengan sistem bioflok pada ikan nila (Oreochromis sp.). Performa yang dimaksud meliputi pertumbuhan, kelangsungan hidup, konversi pakan, dan  kualitas air yang diperoleh selama pemeliharaan. Penelitian ini dilakukan dengan menggunakan metode uji coba secara langsung yang disertai dengan pengamatan terhadap teknologi yang diterapkan. Penelitian ini diawali dengan penentuan tingkat kemiringan dasar kolam dan jumlah bak pengendapan yang dapat memberikan nilai padatan terendah. Desain kolam yang terbaik akan digunakan untuk pemeliharaan ikan nila selama 45 hari dengan berat awal 50 g dengan kepadatan 400 ekor. Selama pemeliharaan dilakukan pengukuran kualitas air, pengukuran berat, pergantian air, dan pemberian pakan. Data hasil penelitian dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa kemiringan dasar bak 20o dengan 2 bak pengendapan menghasilkan tingkat padatan yang lebih rendah pada media pemeliharaan yaitu 20 sampai 30 ml/l. Pemeliharaan ikan menghasilkan ikan dengan total berat 37,1 kg. Nilai konversi pakan yang diperoleh adalah 1,6 dengan tingkat kelangsungan hidup 92%. Kondisi kualitas air sangat berfluktuasi khususnya untuk nilai TDS  kekeruhan, dan DO yaitu masing-masing dengan kisaran 382 – 538 ppm, 8 – 20 NTU, dan, 1,5 - 4,5 ppm. Meskipun telah menerapkan sistem bioflok untuk menjaga kualitas air namun pergantian air tetap harus dilakukan sebanyak 30 sampai 40 % setiap lima hari pada dua minggu pertama pemeliharaan dan selanjutnya dilakukan setiap 3 sampai 4 hari hingga panen.
Everyday Religion and the Complexity of Islamic Space
Authors: Blanch Samuel
Published: December 2022

The turn to ‘everyday religion’ has disrupted the so-called ‘Muslim problem’, suggesting modes of multiculturalism located not in abstract principles of citizenship but grounded in the concrete practices of local communities. In this article, however, I offer two critiques of the literature on everyday religion in Australia. First, the literature has limited itself to discursive methodologies, largely ignoring material aspects of the everyday. Second, I show how studies of everyday religion assume multiculturalism’s location in a given public space. Drawing on ethnography from the Shia Muslim community of Sydney, I show how Shia practices of visual pilgrimage leverage an understanding of complex space that transforms everyday experience. I argue that allowing for diversity requires not merely an attentiveness to different discourses in the public sphere; it requires an allowance for difference at a deeper level, where everyday religion can generate complex alternative experiences of space itself.
Prognostic value of vascular remodeling parameters in the development of adverse cardiovascular events in patients with gastric cancer
Authors: Kirichenko Y. Yu. , Ilgisonis I. S. , Levin P. A. , Belenkov Y. N.
Published: December 2022

Aim. To determine a possible prognostic marker for adverse cardiovascular events in patients with gastric cancer by studying the early and long-term effects of multiagent chemotherapy (MAC) on the structural and functional vascular wall parameters.

Material and methods. The study included 25 patients with newly diagnosed gastric cancer who received courses of chemotherapy with platinum-based agents and fluoropyrimidines. All patients before, immediately after MAC courses and in the long-term period underwent a non-invasive assessment of vascular wall and endothelial function (photoplethysmography (PPG)). In the survivors’ cohort, a correlation analysis was performed to assess the risk of future cardiovascular events depending on changes of PPG parameters.

Results. Before the MAC courses, cancer patients had endothelial dysfunction (mean occlusion index, 1,7 (1,4; 1,9), N>1,8) and structural vascular wall disorders (mean stiffness index, 8,9 m/s (7,7; 9,7), N<8 m/s, mean reflection index, 32,4% (27,5; 37,7), N<30%). All indicators significantly worsened after MAC in the form of endothelial dysfunction progression and vascular remodeling: mean occlusion index, 1,3 (1,2; 1,5) (p<0,0002), stiffness index, 10,3 m/s (9,5; 11,2) (p<0,0001), reflection index, 40,2% (35,5; 43,6) (p<0,001). Long-term follow-up averaged 2,9 years (2,3-3,7 years). All-cause and cardiovascular mortality was 32% and 12%, respectively. Nine patients developed a cardiovascular events (CVEs) (de novo, progression of prior CVD). Significant changes of vascular indicators in the long-term period was not revealed. A trend towards association between increased reflection index and a higher probability of cardiovascular pathology was revealed (OR 1,20, 95% CI 1,01-1,55, p=0,081).

Conclusion. In this study, for the first time, a comprehensive assessment of the effect of MAC on endothelial dysfunction and vascular stiffness, including, in the long-term follow-up period, was carried out in patients with gastric cancer. A significant aggravation of all parameters of vascular remodeling immediately after treatment in the absence of their significant dynamics in the future has been proven. A possible prognostic marker, namely the reflection index, of an unfavorable cardiac outcome in patients with gastric cancer has been identified, which requires further study.
New opportunities for lowering low-density lipoprotein cholesterol: comparative characteristics of PCSK9-targeted therapy
Authors: Zyryanov S. K. , Butranova O. I.
Published: December 2022

The spread of cardiovascular diseases has the nature of an epidemic, which is enhanced by lipid profile disorders, manifested by hypercholesterolemia. Numerous conventional pharmacological tools for lowering cholesterol associated with low density lipoproteins do not make it possible to achieve target values in various categories of patients. Inhibition of proprotein convertase subtilisin/ kexin type 9 (PCSK9) is a promising target in the management of patients with atherosclerotic diseases and includes two main tools — monoclonal antibodies (Alirocumab and Evolocumab) and a small interfering RNA drug (Inclisiran). The presented review is devoted to a comparative analysis of the efficacy and safety of drugs from these groups.
Práticas formativas de uma professora experiente num programa de indução: um estudo de caso
Authors: Reali Aline Maria de Medeiros Rodrigues , Souza Ana Paula Gestoso de
Published: December 2022

Resumo Considerando referências teóricas sobre a base de conhecimento para o ensino, conversas entre professores e pensamento do professor, analisam-se as práticas formativas de uma professora experiente, em sua atuação como mentora de uma professora iniciante em um programa de indução. Realizou-se um estudo de caso exploratório de natureza descritiva-analítica sobre interações virtuais estabelecidas entre elas. A análise de narrativas escritas dessa mentora revelou seu raciocínio pedagógico por meio de diversas ações formativas relacionadas à visualização das práticas e circunscrição dos problemas enfrentados pela iniciante. Desvelou, ainda, que a promoção de processos reflexivos incentivou a iniciante a olhar a própria prática, a projetar formas alternativas de atuação e a experimentá-las.
A internacionalização da Educação Superior: como o tema é tratado pelo campo da Educação?
Authors: Moreira Claudia Regina Baukat Silveira , Ribeiro Mariana Pires
Published: December 2022

Resumo Partindo da premissa de que no início do século XXI houve um importante impulso aos processos de internacionalização da Educação Superior, este trabalho apresenta os resultados de um levantamento bibliográfico a respeito da temática em revistas de excelência na área de Educação. Para tanto, foi selecionado um conjunto de 36 artigos, publicados entre 2014 e 2019, que corresponderam aos descritores utilizados na pesquisa. Da sua análise percebe-se que, apesar de a maioria dos trabalhos poder ser categorizada na perspectiva da política pública da internacionalização da Educação Superior ou da experiência estudantil, há uma grande porosidade no trato da temática, o que dificulta o esforço de síntese.
Prevalência de cinesiofobia e catastrofização em pacientes com disfunção temporomandibular
Authors: Silva Luciana Micaelly Costa Pessoa , Rodrigues Bruna Alves , Lucena Hiênio Ítalo da Silva , Morais Edna Pereira Gomes de , Rocha Ana Carolina , Lucena Luciana Barbosa Sousa de , Alves Giorvan Anderson dos Santos , Benevides Silvia Damasceno
Published: December 2022

RESUMO Objetivo: identificar a frequência e os níveis de cinesiofobia e catastrofização em pacientes com Disfunção Temporomandibular que realizaram terapia fonoaudiológica. Métodos: a amostra compreendeu pacientes com Disfunção Temporomandibular muscular e mista com predominância muscular, grupo de estudo e adultos saudáveis, o grupo controle. Os instrumentos utilizados foram: Diagnostic Criteria for Temporomandibular Disorders, Escala Tampa para Cinesiofobia e Escala de Catastrofização da Dor. A análise estatística foi composta do Teste de Mann-Whitney para comparar as médias entre os grupos de cada escala e o teste de Coeficiente de Correlação de Spearman para analisar a correlação entre as escalas em cada grupo e sua significância. Resultados: foi identificado um alto índice de catastrofização da dor no grupo de estudo em comparação ao grupo controle. Quanto à cinesiofobia, houve maior índice positivo para essa variável no grupo de estudo e menor para o grupo controle. Além disso, identificou-se correlação moderada e positiva entre a cinesiofobia e catastrofização no grupo de estudo. Conclusão: Pacientes com Disfunção Temporomandibular possuem níveis de cinesiofobia e catastrofização mais altos que pacientes que não foram diagnosticados com o distúrbio.
Reinoculation of topdressing Rhizobium tropici combined or not with Azospirillum brasilense in common bean
Authors: Almeida Quirlene Raquel de , Teixeira Itamar Rosa , Silva Gisele Carneiro da , Rocha Ednaldo Cândido , Kikuti Hamilton
Published: December 2022

ABSTRACT The nitrogen (N) supplying capacity of common bean plants through biological fixation is still questioned by farmers. This study aimed to investigate the nodulation, growth and production of common bean cultivars under field conditions, when subjected to topdressing Rhizobium tropici reinoculation applied at different rates, combined or not with Azospirillum brasilense. A randomized blocks design was used, in a 2 × 4 × 2 + 2 factorial arrangement, with four replications. The treatments consisted of two common bean cultivars (BRS-Estilo and BRS-Esteio) reinoculated with four R. tropici rates (0-, 1-, 2- and 4-fold the reference rate), combined or not with A. brasilense in co-inoculation. The additional treatments consisted of nitrogen fertilizer applications (20 and 50 kg ha-1 at planting and as topdressing, respectively) for both cultivars. The variables evaluated at the R6 stage were nodulation (number of active nodules and nodule dry weight) and morphological plant characteristics (root length and dry weight, plant height, shoot dry weight and N content), while, at harvest, the number of pods per plant, number of grains per pod, 100-grain average weight and grain yield were evaluated. The topdressing reinoculation of R. tropici combined with A. brasilense at the V4 stage affected the nodulation process and agronomic characteristics of the common bean plants. When performed in addition to seed inoculation, it may totally replace the supply of mineral N in the crop, allowing the achievement of high yield levels.
Predictors of arteriovenous fistula maturation in hemodialysis patients: a prospective cohort from an ambulatory surgical center in Joinville, Brazil
Authors: Gasparin Claudete , Lima Helbert do Nascimento , Regueira Filho Ademar , Marques Alexandre Gustavo Baggenstoss , Erzinger Gilmar
Published: December 2022

ABSTRACT Introduction: The high rate of arteriovenous fistula maturation failure is a concern in a scenario of growing numbers of patients on hemodialysis. Non-vascular factors tied to maturation success have not been fully discussed. Methods: This prospective observational cohort study included patients with CKD on dialysis or pre-dialysis prescribed arteriovenous fistula creation for the first time in an ambulatory surgical center in Joinville, Brazil, from January 2021 to July 2021. Anthropometric aspects, sociodemographic characteristics, comorbidities, and vascular parameters observed in Doppler ultrasound were analyzed. Variables associated with maturation were analyzed in multivariate models by logistic regression. Results: Eighty-eight of 145 participants (60.1%) were males. Included patients had a median age of 59 years. Successful arteriovenous fistula maturation occurred in 113 (77.9%) patients. Factors such as increased BMI, hematocrit, arm circumference, and skinfold thickness were associated with lower chances of arteriovenous fistula maturation in univariate analysis. On the other hand, larger vein and artery diameter and fistulas in the more proximal portion of the arm were associated with higher maturation success. In multivariate analysis, smoking and larger skinfold and arm circumference were associated with lower chances of successful maturation. Increased systolic blood pressure and vein diameter were associated with greater chance of success. Conclusion: In addition to the vascular parameters assessed in Doppler ultrasonography, factors related to obesity and/or nutritional aspects may influence arteriovenous fistula maturation.
Educação e Filosofia
Authors: Haddad Samir
Published: December 2022

Resumo O trabalho busca problematizar as relações entre filosofia, educação, escola e ensino. Dividiremos a nossa abordagem em três questões balizadoras: as relações da filosofia com a cidade, a atividade de professor e a filosofia e a filosofia como disciplina no sistema escolar, questões que se entrecruzam, se justapõem e se confundem. Cremos que essas reflexões devem apontar os caminhos para nossa reflexão futura.
Breve ensaio sobre o problema do ensino de filosofia
Authors: Oliveira Thiago
Published: December 2022

Resumo: Neste artigo, pretendo debater o ensino de filosofia como um problema genuinamente filosófico, mas que é negligenciado como tal em boa parte dos cursos de licenciatura em Filosofia, bem como em boa parte da chamada produção filosófica no Brasil. Estabeleço uma relação fundamental entre a prática filosófica e o ensino em sala de aula. Defendo a docência em filosofia como um chamado filosófico que convoca docentes e estudantes enquanto pensadores, mesmo que isso não se efetive na realidade concreta. Não pode haver um ensino verdadeiramente filosófico da filosofia se os professores não se colocarem, em sala de aula, como pensadores de fato, muito mais do que meros transmissores altamente capacitados no uso de instrumentos e ferramentas para transmitir conceitos históricos e estudantes dispostos à problematização típica da atividade filosófica. Nesse sentido, a sala de aula de Filosofia deve ser, acima de tudo, um espaço para aquilo que chamarei deatividade filosófica.
“Jardins das ocupações”: estratégias de cuidados diante de perdas ocupacionais e luto
Authors: Nascimento Carla Adriana Vieira do , Souza Airle Miranda de , Corrêa Victor Augusto Cavaleiro
Published: December 2022

Resumo Situações vivenciadas como estressoras, tais como a morte de entes queridos, perda de emprego, sonhos, projetos e outros têm afetado direta ou indiretamente as ocupações rotineiras das pessoas, resultando em rupturas, mudanças e afastamentos das preferências ocupacionais diárias, tanto as externas como as realizadas no ambiente doméstico, o que pode impactar a pessoa e a maneira como se ocupa e participa da vida social. O presente artigo apresenta uma proposta de intervenção e cuidados nas condições de perdas significativas e luto e fomenta reflexões a esse respeito sob uma perspectiva ocupacional, correlacionando conceitos da Ciência da Ocupação, Logoterapia e Análise Existencial de Viktor Frankl. Para tanto, baseia-se na estratégia interventiva de cuidado no luto, denominada “Jardim de Ocupações”, a qual emprega elementos como a metáfora e o desenho como possibilidades para criar aproximações com a fundamentação teórica ancorada na Ciência Ocupacional, sob a ótica da tensão existencial e valores de sentido de Viktor Frankl. Considera-se a proposta interventiva “Jardins de Ocupações” como um instrumento participativo, reflexivo, com potencial para aprofundar reflexões e compreensões sobre os sentidos de vida e o engajamento em ocupações ante às perdas sofridas.
Diferenças de sexo e idade no limiar sensitivo para estimulação elétrica transcutânea
Authors: Saraiva Luanna Hallana Araújo , Viana Luciano da Silva , Pereira Leonardo Costa , Costa Raimundo Jeodar Rodrigues Martins , Holsbach Denise Rodrigues
Published: December 2022

Resumo Introdução A dor é um dos principais sintomas preva-lentes na maioria das patologias. A estimulação elétrica ervosa transcutânea (TENS) se apresenta não apenas como medida terapêutica, como também um meio de quantificar a percepção neurossensitiva e dolorosa em pacientes com dores crônicas. Objetivo Avaliar a relação entre sexo e idade com os limiares neurossensitivos (limiar sensitivo e limiar de tolerância) na aplicação da corrente terapêutica TENS, em pacientes com dores crônicas. Métodos Foram selecionados 45 pacientes com dores crônicas (30 mulheres), com idade entre 24 e 87 anos. Cada paciente respondeu ao Questionário Individual, ao Questionário McGill de Dor (MPQ) e ao Inventário de Depressão de Beck (BDI). Posteriormente, aplicou-se a corrente elétrica TENS, pela qual foram analisados o limiar sensitivo e doloroso, bem como a percepção de acionamento das vias neurossensitivas para cada indivíduo. Os dados foram analisados pelo pacote SPSS 24.0 for Windows. Resultados Não houve correlação significativa (p > 0,05) entre possível diagnós-tico depressivo e a percepção da corrente pelos limiares de sensibilidade e dor. Em relação ao sexo, houve diferença significativa nos limiares sensitivos (p = 0,003) entre homens e mulheres. Já para a queixa de dor e limiar de dor, não foram observadas diferenças estatísticas entre os sexos (p > 0,05). Para as análises correlacionais, identificou-se correlação significativa (p = 0,05) entre as variáveis de índice de massa corporal e limiar de tolerância à dor (r = 0,68) para o sexo feminino e idade e limiar sensitivo (r = 0,65) paro o sexo masculino. Conclusão As diferenças identificadas entre os limiares de sensibilidade entre os sexos, onde as mulheres identificaram o estímulo elétrico significativamente primeiro que os homens, podem auxiliar nas doses de intensidade ou tipo de corrente terapêutica dos pacientes.
“Com dor de dente, tudo é ruim nesta vida!”: saúde bucal na comunidade indígena de Tremembé, Ceará, Brasil
Authors: Maciel Jacques Antonio Cavalcante , Monteiro Ana Kamila Araújo , Pará Jefferson Willyan de Sousa , Sousa Joelton Rosendo , Castro-Silva Igor Iuco
Published: December 2022

Este estudo teve por objetivo analisar a importância do cuidado em saúde bucal de informantes da comunidade indígena Tremembé, em Itarema, Ceará, Brasil. Neste estudo exploratório de caráter qualitativo, foram realizadas entrevistas semiestruturadas com seis adultos considerados informantes-chave da comunidade. As percepções mais presentes nos discursos indicaram o reconhecimento da importância no cuidado em saúde bucal, com foco na higiene dentária, necessária para a socialização. As falas relacionaram a valorização da alimentação saudável, associada à boa qualidade da saúde bucal, com a valorização do conhecimento tradicional como prática de cuidado. No entanto, os discursos apresentaram uma focalização na assistência clínica para adultos, em detrimento de aspectos educativos. As percepções revelaram potencial para integração de cuidados dos profissionais de saúde e dos atores sociais que possuem papel de liderança na comunidade indígena.
Recubrimientos dobles de cerio y epoxi modificados con polipirrol y nanopartículas de plata formados sobre la aleación de Mg AZ91D
Authors: Loperena Ana Paula , Lehr Ivana Leticia , González María Belén , Brugnoni Lorena Inés , Saidman Silvana Beatriz
Published: December 2022

RESUMEN Debido a su biocompatibilidad, biodegradabilidad y características mecánicas similares a las del hueso humano, las aleaciones de Mg constituyen una alternativa prometedora como materiales para la fabricación de implantes temporales. Sin embargo, su alta velocidad de degradación en ambiente fisiológico es un impedimento para estas aplicaciones. Con la finalidad de incrementar la resistencia a la corrosión de la aleación de Mg AZ91D en ambiente fisiológico simulado, se generaron recubrimientos dobles de cerio y epoxi modificados. Como primer paso se sintetizó químicamente polipirrol (PPy) modificado con nanopartículas de plata a partir de pirrol (Py), AgNO3 y Ce(SO4)2. Se sintetizaron dos tamaños de nanopartículas variando la concentración de AgNO3 empleada para la síntesis de los polvos. Se verificó que los compuestos tienen propiedades bactericidas contra la bacteria Gram negativa Escherichia cole (E. cori). A partir de estos resultados, se formó un recubrimiento doble sobre la aleación y éste fue modificado con los polvos sintetizados. El recubrimiento consistió en una primera película base cerio y una segunda película epoxi, a la cual se le adicionó un 1% p/p de los compuestos bactericidas. Análisis electroquímicos como polarizaciones anódicas, curvas de polarización de Tafo, variación del potencial de circuito abierto (PCA) y espectroscopia de impedancia electroquímica (EIS) verificaron que los recubrimientos modificados fueron capaces de proteger al sustrato contra la corrosión en solución fisiológica simulada. A su vez, la adición del compuesto de PPy y plata confiere propiedades antibacteriales al recubrimiento, las cuales fueron evaluadas mediante la técnica de Kirby-Bauer contra la bacteria E. coli.