bluuebunny/crossref_metadata_2025 huggingface dataset:
The automorphism group and fixing number of orthogonality graph over a vector space
Authors: Ou Shikun , Tan Yanfei
Published: September 2021

Let [Formula: see text] be a field, and [Formula: see text] the [Formula: see text]-dimensional row vector space over [Formula: see text]. The orthogonality graph [Formula: see text] of [Formula: see text] is an undirected simple graph which has [Formula: see text] as its vertex set, and for distinct [Formula: see text], [Formula: see text] if and only if [Formula: see text], where [Formula: see text] is the transpose of [Formula: see text]. When [Formula: see text] is finite, it is shown that any automorphism of [Formula: see text] can be decomposed into the product of a row-orthogonal automorphism and either a permutation automorphism or a field automorphism; moreover, the fixing number and metric dimension of [Formula: see text] are considered.
GENDER, POVERTY AND ENTREPRENEURSHIP: A SYSTEMATIC LITERATURE REVIEW AND FUTURE RESEARCH AGENDA
Authors: SANTOS SUSANA C. , NEUMEYER XAVER
Published: September 2021

Women represent the majority of the poor worldwide and entrepreneurship is widely argued to be critical for alleviating poverty conditions. However, research on this topic is dispersed and fragmented across various research domains and contexts. In this paper, we provide a broader perspective on the relationship between gender and poverty entrepreneurship. The purpose of this review is to acknowledge and critically discuss the variety of studies on gender and poverty entrepreneurship published over the last three decades. Using a systematic literature review process and an inductive categorization, we offer an overarching framework for organizing what we know about gendered entrepreneurial activity under poverty conditions including the relevant antecedents, mechanisms, outcomes and characteristics. In doing so, this article develops a roadmap of the current knowledge and provides suggestions to guide future research.
Layer-by-Layer Structure Design of G@SiOx@PPY Materials as Promising High-Performance Anodes for Lithium-Ion Batteries
Authors: Zhang Jiaying , Li Ting , Li Chao , Zhang Jingjing , Lv Chun Ju , Chen Zhi , Fan Meiqiang , Sheng Meide
Published: September 2021

The graphene/silicon oxide/polypyrrole (G/SiOx/PPY) material was prepared in this paper. The G/SiOx/PPY material has good electrochemical performances including high capacity and cyclic stability. It has 2068/2130[Formula: see text]mAh g[Formula: see text] of capacity after 100th charge/discharge cycle at 200[Formula: see text]mA[Formula: see text]g[Formula: see text] of current density and 575/569[Formula: see text]mAh[Formula: see text]g[Formula: see text] of capacity after 100th charge/discharge cycle at 2000[Formula: see text]mA g[Formula: see text] of current density when G/SiOx molar ratio is 1:5. Its capacity increases but its cyclic stability decreases with G/SiOx molar ratio decreasing from 1:1 to 1:3 and 1:5. The electrochemical performance improvement of the G/SiOx/PPY material is due to the synergetic effect of graphene and polypyrrole, which improve the conductivity of SiOx and prevent its dropping from the surface of the electrode caused by the stress due to the volume expansion and shrinkage in charge/discharge cycles.
Mechanochromic behavior of a pyridine-containing pyrene derivative
Authors: Zhang Na , Wang Haoxiang , Shen Lei , Wang Taisheng
Published: September 2021

Pyrene-based hydrazone derivative (PYI) which was synthesized from 1-pyrene formaldehyde and isoniazid presented a mechanochromic (MC) behavior and self-recovery performance at room temperature. Mild grinding of a PYI crystal would convert its fluorescence from weak blue to yellow. The metastable grinded PYI powders could revert to the original stable state at room temperature (RT) in 24 h. However, under the same conditions, the control molecule PYB did not exhibit MC property. The results showed that the MC behavior of PYI was caused by mechanical induced slippage of the pyrene dimers in the lattice, which altered the stacking behavior and molecular interactions. Because the two pyrene units in PYB dimer almost exhibited a sandwich-type arrangement, mechanical stimulus had little influence on the stacking state of PYB. Therefore, it did not exhibit the MC property. In addition, when mixed with oxalic acid and malonic acid, the fluorescence of pristine PYI was turned off, meanwhile with a visible color change from yellow to orange red. The phenomenon was a result of enhanced ICT effect between acidifying pyridine and pyrene unit.
Unipolar electron transport polymer semiconductor based on fluorine- and nitrogen-substituted units for field-effect transistors
Authors: Hao Xiaojun , Yang Xiaofan , Zhao Hongyu , Li Tingpeng
Published: September 2021

The unipolar electron transport conjugated polymers play an important role in organic semiconductors. In this work, a unipolar electron transport polymer semiconductor was designed and synthesized based on fluorination on the donor unit and replacement of nitrogen on the acceptor unit. The optical properties, electrochemistry properties, and film morphology were systematically characterized and investigated. Heteroatom with large electronegativity could effectively lower the molecular orbital energy levels of conjugated polymer. Organic field-effect transistors (OFETs) devices were fabricated to investigate the charge transport properties. Unipolar electron transport characteristics were obtained with the highest field-effect mobility of over 0.03 cm2V[Formula: see text]s[Formula: see text].
Structural and Electrical Characteristics of FeTiVO6 Double Perovskite
Authors: Arya B. B. , Nayak S. , Choudhary R. N. P.
Published: September 2021

In this paper, studies of structural as well as electrical characteristics of the double perovskite material FeTiVO6 (iron titanium vanadate), synthesized by a high-temperature mixed oxide reaction method have been discussed. The room temperature X-ray diffraction analysis confirms the formation of a single-phase orthorhombic structure without any secondary phase. All the electrical characteristics (i.e., dielectric, impedance, conductivity and modulus) of the sample, studied at various temperatures (25–300°C) and frequencies (1[Formula: see text]kHz–1[Formula: see text]MHz), provide many remarkable characteristics of the material. The dielectric parameters as a function of frequency explain the presence of different polarization mechanisms based on the Maxwell–Wagner double-layer model. Impedance analysis describes the grain (bulk) and grain boundary (bulk interior) effect on the material using the equivalent RQC-RC circuits. The presence of non-Debye type of relaxation behavior in the material is confirmed by the depressed semicircles of Nyquist plots. The conductivity study provides information about the CBH and OLPT type of conduction phenomenon. The temperature dependence of leakage current behavior follows the Ohmic (semiconductor) and space charge limited conduction mechanisms at a different range of applied fields. The occurrence of the room temperature hysteresis loop obtained from the PE loop tracer confirms the ferroelectric behavior of the studied compound.
One-dimensional consolidation of multilayered aquifer systems with viscoelastic properties induced by time-dependent groundwater drawdown
Authors: Yang Weitao , Xu Jin
Published: September 2021

Most analytical and semi-analytical models for pumping-induced land subsidence invoke the simplifying assumptions regarding characteristics of geomaterials, as well as the pattern of drawdown response to pumping. This paper presents an analytical solution for one-dimensional consolidation of the multilayered soil due to groundwater drawdown, in which viscoelastic property and time-dependent drawdown are taken into account. The presented solution is developed by using the boundary transformation techniques. The validity of the proposed solution is verified by comparing with a degenerated case for a single layer, as well as with the numerical solutions and experimental results for a two-layer system. The difference between the average consolidation degree
U
p
, defined by hydraulic head, and
U
s
, defined by total settlement, is discussed. Detailed parametric studies are conducted to reveal the effects of viscoelastic properties and drawdown patterns on the consolidation process. It is revealed that while the effect of different drawdown response patterns is significant during the early–intermediate stages of consolidation, the viscoelastic properties may have a more dominant influence on long-term consolidation behaviour, depending on the values of the material parameters, which are reflected in both the deformation process of soil layers and the dissipation of excess pore-water pressure.
Weighting of Basic Indices for Value for Money Qualitative Evaluation of the Public-Private Partnership Aged Care Project through the Analytic Hierarchy Process
Authors: Ye Song , Chen Ying , Mao Guangao
Published: September 2021

The evaluation of value for money (VFM) is an essential part of the pre-evaluation of public-private partnership (PPP) projects in China. It can be divided into qualitative evaluation and quantitative evaluation. However, there is no uniform weighting criterion for the indices of qualitative evaluation. To reasonably weigh the qualitative evaluation indices, this paper sorts and measures these indices through the analytic hierarchy process (AHP), using the public data on preapplied PPP aged care projects, and obtains the reference values. On this basis, several suggestions were put forward to standardize and develop VFM evaluation of PPP aged care projects, such as improve the scientific VFM evaluation system and realize whole-process performance appraisal. Based on actual project data, the qualitative evaluation is more objective than the analysis based on subjective experience. Therefore, our findings promote the application of VFM qualitative evaluation.
Necrotizing Ulcerative Gingivitis, a Rare Manifestation as a Sequel of Drug-Induced Gingival Overgrowth: A Case Report
Authors: Damdoum Marah , Varma Sudhir Rama , Jaber Mohamed A. , Nambiar Manjusha
Published: September 2021

Purpose. The purpose of this case report is to present a rare case of amlodipine-induced gingival overgrowth with a secondary formation of necrotizing ulcerative gingivitis involving the upper and lower arches of a 68-year-old female patient with a chief complaint of “swollen gums and pain on mastication which has been recurring for the past 5 years.” Materials and Methods. The treatment plan of this case was divided according to quadrants of the mouth. Each week, one quadrant was surgically excised, and the remaining quadrants were observed for any changes. The gingival overgrowths were excised using a 15 blade, and debris/plaque was removed with Gracey curettes. Results. Although full-mouth exodontia was performed, the patient unfortunately suffered with recurrences in GO. These results are suggestive of idiopathic causes of GO. Conclusion. Careful examination, physician referrals, and biopsy to rule out any specific anomalies and to assist in proper diagnosis are followed by sequential management of the case results in productive outcomes.
Networked Artificial Intelligence English Translation System Based on an Intelligent Knowledge Base and Translation Method Thereof
Authors: Ren Shuping
Published: September 2021

Language translation is often conducted in work and study. Traditional language translation is based on lexical structure analysis. However, natural language is not so standardized, which causes this translation method to have fundamental defects, no matter how much the algorithm is improved. The translation results and human translation will be very different. This paper mainly studies the networked artificial intelligence. The English translation system and translation methods are based on a smart knowledge base. Bringing an example of English-Chinese translation to suggest translations according to the intelligent knowledge base explains in detail the principle of intelligent knowledge-based translation and the advantage of this translation method compared with the traditional translation method based on lexical structure analysis. In the experiment of this paper, when the variance is 2/N, 30/N, 100/N, and 2N, it is the experimental data for an in-depth study. When the variance is 2/N, 30/N, and 100/N, the result is the same as that when the variance is 0.5; the result when the variance is 2N also conforms to the trend in the tables, which is close to the effect of the smoothing algorithm, which verifies the effectiveness of the system in this paper.
Undiagnosed Behçet’s Disease Presenting as Fournier’s Gangrene in a Young Male
Authors: Winyard Jasmine C. , Wong Anton , Rashed Hala , Mellon John K.
Published: September 2021

Behçet’s disease is rare, especially in the paediatric population. In this case, a healthy 16-year-old made presented with discrete scrotal ulcers and systemic illness. He was found to have Fournier’s gangrene and with subsequent investigation was diagnosed with Behçet’s disease as an underlying cause. A PubMed search reveals no similar case reports. His only risk factors for Fournier’s gangrene was his raised body mass index. His only risk factor for Behçet’s disease was his ethnic origin. An understanding of risk factors and epidemiology can raise suspicion of these rare pathologies.
Challenges Faced by the Development Support Group in Implementing the Integrated Quality Management System in Circuit 04 Schools in the Mthatha Education District
Authors: Tachie Simon Adjei , Mancotywa Nandi Carol
Published: September 2021

The purpose of this study was to investigate challenges faced by Development Support Groups (DSGs) in implementing the Integrated Quality Management System (IQMS) in the primary schools of Circuit 04 of the Mthatha District of the Eastern Cape Province, South Africa. The scope of this research was restricted to four primary schools in Circuit 04. The research methodology was qualitative in nature, and a multiple case study strategy was employed. The sampling strategy was convenience sampling and included DSGs and teachers. Data were collected through face-to-face individual in-depth interviews to elicit information from DSGs and teachers. The IQMS is performed through the completion of special instruments, which help to rate and score teachers on their performances. During IQMS, two structures, the DSGs and School Development Team (SDT), are created to implement developmental appraisal and performance management (or summative evaluation). The main finding of this study revealed that even though school principals were part of the team and structure to manage the IQMS, some principals did not drive or influence the process resulting in some schools finding it difficult to effectively manage the IQMS. Challenges, thus, faced by DSGs tended to have a negative effect on the teachers as well as on learner performance.
Anti-VEGF Antibody Protects against Alveolar Exudate Leakage Caused by Vascular Hyperpermeability, Resulting in Mitigation of Pneumonitis Induced by Immunotherapy
Authors: Iwai Toshiki , Sugimoto Masamichi , Patel Hina , Yorozu Keigo , Kurasawa Mitsue , Kondoh Osamu
Published: September 2021

Immune-related pneumonitis is an important toxicity associated with checkpoint inhibitor therapy with anti–PD-1 or anti–PD-L1 antibodies, often necessitating discontinuation of treatment. Development of methods to mitigate checkpoint inhibitor–related pneumonitis is required.

The contributions of PD-L1, PD-L2, and VEGF to the pathogenesis of pneumonitis were examined in an IL2- plus IL18-induced mouse pneumonitis model (IL pneumonitis model). Furthermore, the incidences of pneumonitis were retrospectively examined in patients with non–small cell lung cancer treated with the anti–PD-L1 mAb atezolizumab plus chemotherapy, with or without the anti-VEGF mAb bevacizumab, in the phase III IMpower150 trial. PD-1 signal blockade by anti–PD-L1 and anti–PD-L2 antibodies aggravated pneumonitis in the IL pneumonitis model. An anti-VEGF antibody prevented PD-1 signal blockade from aggravating pneumonitis in this model. PD-1 signal blockade induced interstitial T-cell infiltration in the lungs, but VEGF blockade did not affect this T-cell infiltration. The anti-VEGF antibody protected against vascular-to-alveolar leakage of protein and fluid due to PD-1 signal blockade in a murine model. In the IMpower150 trial, incidence rates of pneumonitis of any grade were 4.3% in the group without bevacizumab and 2.8% in the group with bevacizumab. In patients with pneumonitis, outcomes of “Not recovered/Not resolved” were reported for 29.4% in the group without bevacizumab compared with 9.1% in the group with bevacizumab. Our findings suggest that anti-VEGF antibodies in combination with checkpoint inhibitors may be a treatment method that can control checkpoint inhibitor–related pneumonitis.
Predictive Value of MRP-1 in Localized High-Risk Soft Tissue Sarcomas: A Translational Research Associated to ISG-STS 1001 Randomized Phase III Trial
Authors: Martin-Broto Javier , Lopez-Alvarez Maria , Moura David S. , Ramos Rafael , Collini Paola , Romagosa Cleofe , Bagué Silvia , Renne Salvatore L. , Barisella Marta , Velasco Valerie , Coindre Jean-Michel , Lopez-Lopez Daniel , Dopazo Joaquin , Gambarotti Marco , Braglia Luca , Merlo Domenico Franco , Palmerini Emanuela , Stacchiotti Silvia , Quagliuolo Vittorio L. , Lopez-Pousa Antonio , Grignani Giovanni , Blay Jean-Yves , Brunello Antonella , Gutierrez Antonio , Valverde Claudia , Hindi Nadia , Dei Tos Angelo Paolo , Picci Piero , Casali Paolo G. , Gronchi Alessandro
Published: September 2021

MRP-1 is implicated in multidrug resistance and was described as prognostic in high-risk patients with soft-tissue sarcoma (STS) in a previous study. The current research aimed to validate MRP-1 prognostic/predictive value in localized sarcomas treated with anthracyclines plus ifosfamide within the ISG-1001 phase III study. In addition, the inhibitory activity on MRP-1 was investigated in preclinical studies to identify new combinations able to increase the efficacy of standard chemotherapy in STS. MRP-1 expression was assessed by IHC in tissue microarrays from patients with STS and tested for correlation with disease-free survival (DFS) and overall survival (OS). In vitro studies tested the efficacy of MRP-1 inhibitors (nilotinib, ripretinib, selumetinib, and avapritinib) in sarcoma cell lines. The effect of combinations of the most active MRP-1 inhibitors and chemotherapy was measured on the basis of apoptosis. MRP-1 was evaluable in 231 of 264 cases who entered the study. MRP-1 expression (strong intensity) was independently associated with worse DFS [HR, 1.78; 95% confidence interval (CI), 1.11–2.83; P = 0.016], in the multivariate analysis, with a trend for a worse OS (HR, 1.78; 95% CI, 0.97–3.25; P = 0.062). In vitro studies showed that the addition of MRP-1 inhibitors (nilotinib or avapritinib) to doxorubicin plus palifosfamide, significantly increased cell death in SK-UT-1 and CP0024 cell lines. MRP-1 is an adverse predictive factor in localized high-risk patients with STS treated with neoadjuvant anthracyclines plus ifosfamide followed by surgery. In vitro findings support the clinical assessment of the combination of chemotherapy and MRP-1 inhibitors as a promising strategy to overcome the drug ceiling effect for chemotherapy.
Sickle Cell Disease-Induced Pulmonary Hypertension: A Review of Pathophysiology, Management, and Current Literature
Authors: Sheikh Abu Baker , Nasrullah Adeel , Lopez Erick Daniel , Tanveer Ud Din Mian , Sagheer Shazib , Shah Ishan , Javed Nismat , Shekhar Rahul
Published: September 2021

Sickle cell disease is an inherited hemoglobinopathy leading to the synthesis of hemoglobin S. Hemoglobin S results in the formation of abnormal sickle-shaped erythrocytes that lead to hematologic abnormalities such as hemolytic anemia and increased risks of thrombosis. Another particular problem encountered with the disease is pulmonary hypertension. The objective of this narrative review is to discuss the prevalence, pathophysiology mechanisms, diagnostic techniques, treatment options, and prognostic indicators in the setting of sickle cell disease with pulmonary hypertension. Additionally, the review also highlights other advancements that are being investigated. Considering the significant morbidity, mortality, and prevalence of pulmonary hypertension in patients with sickle cell disease, it is important to account for the aforementioned domains in the future guidelines to provide optimal and individualized care to the high-risk individuals as well as reduce the progression of disease, morbidity, and mortality rates.
Spondyloarthritis in Taihangshan Macaques (Macaca mulatta tcheliensis)
Authors: Pang Ke-Li , Jin Qin-Qin , Yuan Zan-An , Kuang Zhen-Jing , Lu Ji-Qi , Tian Jundong
Published: September 2021

The rhesus macaque (Macaca mulatta) is the most widely distributed nonhuman primate species, and captive populations play an important role in biomedical research due to close phylogenetic and physiological similarity to human beings. However, to our best knowledge, the spondyloarthritis (SpA) in rhesus macaques has been exclusively reported in captive or semicaptive populations rather than wild counterparts. In the present study, we report 2 cases of SpA observed in Taihangshan macaques (Macaca mulatta tcheliensis) inhabiting the Taihangshan Macaque National Nature Reserve, Henan Province, China. Among these 2 cases, one can be diagnosed as ankylosing spondylitis (AS) following accepted medical criteria, and another case showed evident fusion at the pubic symphysis which could be specific to rhesus macaque AS. We discuss the potential causes leading directly or indirectly to the development of SpA.
Review of the Oriental species of the genus Brachycerocoris Costa, 1863 (Hemiptera: Pentatomoidea: Pentatomidae: Podopinae s.l.) with description of two new species
Authors: SALINI S. , ROCA-CUSACHS M.
Published: September 2021

The Oriental species belonging to genus Brachycerocoris Costa, 1863 (Hemiptera: Pentatomoidea: Pentatomidae: Podopinae s.l.) are revised with description of two new species, B. petrii sp. nov. and B. davidii sp. nov. from India and Philippines respectively. Brachycerocoris camelus Costa, 1863 is diagnosed and illustrated for female genitalia and B. dromedarius (Vollenhoven, 1863) is diagnosed and illustrated for both male and female genitalia. Additionally, host record, bionomics of B. petrii sp. nov. and a key to the Oriental species are provided.
Integrative taxonomy reveals remarkable diversity in Australian Protomiltogramma (Diptera: Sarcophagidae)
Authors: JOHNSTON NIKOLAS P. , WALLMAN JAMES F. , SZPILA KRZYSZTOF , PAPE THOMAS
Published: September 2021

Protomiltogramma Townsend is the largest and most diverse genus of miltogrammine flesh flies in Australia. However, no comprehensive taxonomic work had been completed on the Australian members of this genus in almost a century. This study presents the first taxonomic revision of all Australian species of Protomiltogramma (Sarcophagidae: Miltogramminae), completed using an integrative approach combining molecular and morphological data. Eight new species endemic to Australia are described: P. dalbiensis sp. n., P. grandis sp. n., P. incana sp. n., P. kapnos sp. n., P. nigrisensa sp. n., P. popularis sp. n., P. rubra sp. n. and P. subtilis sp. n. In addition, P. australis Malloch, 1930 is synonymised with P. cincta Townsend, 1916, syn. n. and P. mallochi Verves, 1987 is synonymised with P. laticeps Malloch, 1930, syn. n. Molecular phylogenetics is used to place the Australian Protomiltogramma among the miltogrammine genera of the world.
The mediating role of self-esteem in the relationship between childhood maltreatment and god image among Turkish Muslims
Authors: Kıraç Ferdi
Published: September 2021

Childhood maltreatment is widespread in predominantly Muslim countries. However, the research investigating the impact of childhood maltreatment on the adult survivors’ religious and spiritual lives has mainly focused on Western Judeo-Christian samples. Considering cross-cultural differences in religious beliefs, in this study, we investigated the relationship between childhood maltreatment and god image, and the mediating role of self-esteem in a sample of Muslim Turkish adults. Eight hundred two participants completed Childhood Trauma Questionnaire–Short Form, God Perception Scale, and Self-Esteem Scale. Findings revealed that all childhood maltreatment subtypes predicted negative image of god and self-esteem mediated some of the negative effects of each maltreatment subtype on god image. The study also found that emotional neglect was the most prominent predictor of negative image of god, followed by emotional abuse. Based on attachment theory, we concluded that the emotional component of childhood maltreatment had more long-lasting adverse consequences in survivors’s relationship with god in Muslim adults.
Genome-wide analysis and expression profiles of PdeMYB transcription factors in colored-leaf poplar (Populus deltoids)
Authors: Zhuang Weibing , Shu Xiaochun , Lu Xinya , Wang Tao , Zhang Fengjiao , Wang Ning , Wang Zhong
Published: September 2021

Background

MYB transcription factors, comprising one of the largest transcription factor families in plants, play many roles in secondary metabolism, especially in anthocyanin biosynthesis. However, the functions of the PdeMYB transcription factor in colored-leaf poplar remain elusive.

Results

In the present study, genome-wide characterization of the PdeMYB genes in colored-leaf poplar (Populus deltoids) was conducted. A total of 302 PdeMYB transcription factors were identified, including 183 R2R3-MYB, five R1R2R3-MYB, one 4R-MYB, and 113 1R-MYB transcription factor genes. Genomic localization and paralogs of PdeMYB genes mapped 289 genes on 19 chromosomes, with collinearity relationships among genes. The conserved domain, gene structure, and evolutionary relationships of the PdeMYB genes were also established and analyzed. The expression levels of PdeMYB genes were obtained from previous data in green leaf poplar (L2025) and colored leaf poplar (QHP) as well as our own qRT-PCR analysis data in green leaf poplar (L2025) and colored leaf poplar (CHP), which provide valuable clues for further functional characterization of PdeMYB genes.

Conclusions

The above results provide not only comprehensive insights into the structure and functions of PdeMYB genes but also provide candidate genes for the future improvement of leaf colorization in Populus deltoids.
Process evaluation of an implementation study in dementia care (EIT-4-BPSD): stakeholder perspectives
Authors: Behrens Liza , Boltz Marie , Riley Kiernan , Eshraghi Karen , Resnick Barbara , Galik Elizabeth , Ellis Jeanette , Kolanowski Ann , Van Haitsma Kimberly
Published: September 2021

Background

Behavioral and psychological symptoms of distress in dementia (BPSD) are major drivers of poor quality of life, caregiver burden, institutionalization, and cost of care in nursing homes. The Evidence Integration Triangle (EIT)-4-BPSD in nursing homes was a pragmatic Hybrid III trial of an implementation strategy to help staff use evidence-based non-pharmacological interventions to prevent and manage BPSD. This study aimed to describe and explore the stakeholders’ perceptions of the process to implement the EIT-4-BPSD strategy including its utility, and the barriers and facilitators to implementation in real-world settings.

Methods

EIT-4-BPSD was a multi-layer implementation strategy that engaged nursing home stakeholder groups to define community specific goals towards reducing BPSD over a 12-month period. Stakeholder groups from nursing homes that completed all 12-months of the implementation strategy were invited to participate in this process evaluation study. Qualitative data from focus group transcripts were analyzed using a conventional content analysis. Emerging codes were sorted into categories, then organized in meaningful clusters based on the domains of the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework.

Results

The EIT-4-BPSD implementation strategy was completed in 21 nursing homes; 93 stakeholders participated in focus groups. Over half of participating nursing homes reported meeting their BPSD goals as expected or more. Challenges, facilitators, and contextual factors reported by stakeholder members explains variability in the implementation of EIT-4-BPSD strategy in 11 key categories: family; staff; organizational; staff, environmental, and resident outcomes; utility of EIT resources; adoption barriers and facilitators; care process adaptations; and future planning.

Conclusion

Stakeholders offered guidance on salient factors influencing the feasibility and utility of EIT-4-BPSD adoption and implementation to consider in future implementation research that aims to improve behavioral well-being in NH residents living with dementia. Engagement of family and staff at all levels of the organization (Management, leadership, and direct care); and measurement of staff, environmental, and resident outcomes were perceived as critical for future implementation success. While regulations, finances, and competing demands on staff time were perceived as reducing implementation success.

Trial Registration

The Testing the Implementation of EIT-4-BPSD study was registered in the ClinicalTrials.gov (NCT03014570) January 9, 2017.
Whole genome sequencing in the diagnosis of primary ciliary dyskinesia
Authors: Wheway Gabrielle , Thomas N. Simon , Carroll Mary , Coles Janice , Doherty Regan ,   Genomics England Research Consortium, Goggin Patricia , Green Ben , Harris Amanda , Hunt David , Jackson Claire L. , Lord Jenny , Mennella Vito , Thompson James , Walker Woolf T. , Lucas Jane S.
Published: September 2021

Background

It is estimated that 1–13% of cases of bronchiectasis in adults globally are attributable to primary ciliary dyskinesia (PCD) but many adult patients with bronchiectasis have not been investigated for PCD. PCD is a disorder caused by mutations in genes required for motile cilium structure or function, resulting in impaired mucociliary clearance. Symptoms appear in infancy but diagnosis is often late or missed, often due to the lack of a “gold standard” diagnostic tool and non-specific symptoms. Mutations in > 50 genes account for around 70% of cases, with additional genes, and non-coding, synonymous, missense changes or structural variants (SVs) in known genes presumed to account for the missing heritability.

Methods

UK patients with no identified genetic confirmation for the cause of their PCD or bronchiectasis were eligible for whole genome sequencing (WGS) in the Genomics England Ltd 100,000 Genomes Project. 21 PCD probands and 52 non-cystic fibrosis (CF) bronchiectasis probands were recruited in Wessex Genome Medicine Centre (GMC). We carried out analysis of single nucleotide variants (SNVs) and SVs in all families recruited in Wessex GMC.

Results

16/21 probands in the PCD cohort received confirmed (n = 9), probable (n = 4) or possible (n = 3) diagnosis from WGS, although 13/16 of these could have been picked up by current standard of care gene panel testing. In the other cases, SVs were identified which were missed by panel testing. We identified variants in novel PCD candidate genes (IFT140 and PLK4) in 2 probands in the PCD cohort. 3/52 probands in the non-CF bronchiectasis cohort received a confirmed (n = 2) or possible (n = 1) diagnosis of PCD. We identified variants in novel PCD candidate genes (CFAP53 and CEP164) in 2 further probands in the non-CF bronchiectasis cohort.

Conclusions

Genetic testing is an important component of diagnosing PCD, especially in cases of atypical disease history. WGS is effective in cases where prior gene panel testing has found no variants or only heterozygous variants. In these cases it may detect SVs and is a powerful tool for novel gene discovery.
AprGPD: the apricot genomic and phenotypic database
Authors: Chen Chen , Liu Huimin , Gou Ningning , Huang Mengzhen , Xu Wanyu , Zhu Xuchun , Yin Mingyu , Bai Haikun , Wang Lin , Wuyun Ta-na
Published: September 2021

Background

Apricot is cultivated worldwide because of its high nutritive content and strong adaptability. Its flesh is delicious and has a unique and pleasant aroma. Apricot kernel is also consumed as nuts. The genome of apricot has been sequenced, and the transcriptome, resequencing, and phenotype data have been increasely generated. However, with the emergence of new information, the data are expected to integrate, and disseminate.

Results

To better manage the continuous addition of new data and increase convenience, we constructed the apricot genomic and phenotypic database (AprGPD, http://apricotgpd.com). At present, AprGPD contains three reference genomes, 1692 germplasms, 306 genome resequencing data, 90 RNA sequencing data. A set of user-friendly query, analysis, and visualization tools have been implemented in AprGPD. We have also performed a detailed analysis of 59 transcription factor families for the three genomes of apricot.

Conclusion

Six modules are displayed in AprGPD, including species, germplasm, genome, variation, product, tools. The data integrated by AprGPD will be helpful for the molecular breeding of apricot.
Autokreacja ról politycznych Komitetu Obrony Demokracji w mitycznym uniwersum polskiej sceny politycznej
Authors: Rak Joanna
Published: September 2021

Głównymi celami tego artykułu są identyfikacja mitów ról politycznych, które zostały wykorzystane przez Komitet Obrony Demokracji (KOD) do stworzenia językowego obrazu jego powstania, a także wyjaśnienie znaczenia konfiguracji tych struktur semantycznych dla autokreacji ról politycznych, które okazały się efektywnym bodźcem dla oddolnej mobilizacji przeciwników Prawa i Sprawiedliwości. Zostaną one zrealizowane przy wykorzystaniu analizy źródeł, jakościowej relacyjnej analizy zawartości i typologii mitów. Z kolei cel poboczny artykułu stanowi weryfikacja użyteczności analitycznej narzędzia teoretycznego w postaci typologii mitów, których przedmiotem są role polityczne. Testowi poddano siatkę kategorii teoretycznych obejmującą cztery pary typów idealnych mitów: antropolatryzującego i diabolizującego, teofanijnego i demonizującego, boskiego i diabelskiego mesistesu oraz katechonu i antychrysta. Wykorzystanie tych kategorii teoretycznych do zidentyfikowania i rozróżnienia dyskursywnych kreacji oraz autokreacji ruchu społecznego pokazało, że dzielą one pole semantyczne mitu roli politycznej w taki sposób, że jego typy idealne są rozłączne i umożliwiają rozpoznanie podstawowych konstruktów semantycznych ról politycznych. Uwidoczniło również, że KOD zaniechał skrajnie pozytywnego i negatywnego wartościowania siebie i swoich oponentów politycznych. Do dyskursywnej autolegitymizacji w systemie politycznym wykorzystał mity teofanijny, boskiego mesistesu i katechonu. Do delegitymizacji rządzących podmiotów politycznych zastosował mity demonizujący i antychrysta. Obraz powstania ruchu był wyrazem poczucia konieczności powstania i działania dobrego katechonu, który powstrzyma antychrysta przed zniszczeniem systemu demokratycznego w Polsce i przyczyni się do ochrony i zachowania jego konstytutywnych wartości.
Polityczne i wojskowe aspekty stosunków między Chińską Republiką Ludową i niepodległym Sudanem Południowym
Authors: Jureńczyk Łukasz
Published: September 2021

Przedmiotem analizy są polityczne i wojskowe aspekty stosunków między Chińską Republiką Ludową i Sudanem Południowym. W pierwszej części artykułu omówiono aspekty polityczne, a w drugiej części aspekty wojskowe współpracy między państwami. Polityczno-wojskowe stosunki dwustronne zdominowane są kwestią konfliktów militarnych Sudanu Południowego. Chiny angażują się w działania na rzecz stabilizacji sytuacji bezpieczeństwa w Sudanie Południowym, jednak przede wszystkim koncentrują się na ochronie własnych interesów w tym państwie i regionie Afryki Wschodniej. Rozważania prowadzone są z perspektywy zarówno krajowej, jak i międzynarodowej.
Droga, brama, szczelina. „Przejście” jako element symboliczny we współczesnych pomnikach i miejscach pamięci
Authors: Zaborski Marcin
Published: September 2021

Tekst przedstawia zagadnienia związane ze współczesnymi miejscami pamięci. Autor analizuje symbolikę pomników i memoriałów, w których osią upamiętnienia jest „przejście”, brama, szczelina. Pyta o intencje twórców takich miejsc pamięci i podkreśla, że są one nie tylko reprezentacją przeszłości. Zdobywając status symbolu, wyraźnie wpływają na zbiorową wyobraźnię. Nie tylko pielęgnują wspomnienia, ale też odgrywają ważną rolę w budowaniu mostów między przeszłością a teraźniejszością. Wspierają edukację obywatelską i kształtują postawy społeczne.
Nutritional Status of Children Under Five Years in the Work Area of Puskesmas Cipadung
Authors: Nafia Zidni Ilma , Shodiq Istiqomah Zakiyah , Handayani Lina
Published: September 2021

Background: Children under five years are in the golden growth and development period; however, an excellent nutritional status must support optimal growth and development. The nutritional status of children under five years needs special attention. An overview of the nutritional status of children in a region is the first step to determine the factors that affect the nutritional status of children under five in that region. Method: This was a descriptive study with a cross-sectional design. Results: The results showed that children under five aged 0 – 23 months were 35.47%, while those aged 24-59 months were 64.53%, boys were 52.95%, and girls were 47.05%. Children under five years with inferior nutritional status (index weight/age) of 2.63%, children with nutritional status of stunting (index for height/age) of 12.57%. Children with a malnutrition status (index weight/height) of 2.41%. Conclusion: The problem of stunting and wasting nutrition is still found in the work area Puskesmas Cipadung. These problems can arise due to poor parenting and lack of nutritious food intake due to parents' low education and income level.
ESTUDO DE MÉTODOS PARA PREVISÃO DA PRODUÇÃO DE GRÃOS NO BRASIL VIA SÉRIES TEMPORAIS
Authors: Wolfart Simone Beatriz , Lima José Donizetti de , Oliveira Gilson Adamczuk , Fritsch Neto Armenio
Published: September 2021

A previsão é uma ferramenta fundamental para se posicionar estrategicamente frente aos negócios futuros. O objetivo deste artigo é estudar a previsão da produção de grãos no Brasil, utilizando os dados históricos disponibilizados pela CONAB, no período de 1976/1977 a 2018/2019, via análise de séries temporais. Foi utilizado o método Box & Jenkis para realizações das previsões. A definição do melhor modelo foi por meio da avaliação dos erros de previsão calculados para cada modelo e escolhido o que melhor representa a série analisada. O modelo que mais se adequou foi o ARIMA (1,1,2), com MAPE de 7,1% (validação) e 5,4%(teste) com AIC 18,05. Com os resultados obtidos na previsão da produção, percebeu-se que o modelo escolhido atendeu a expectativa da previsão, pois gerou resultados dentro dos limites inferiores e superiores de variação com 95% de confiança.
Trajetória dos cursos de graduação do Instituto de Nutrição Josué de Castro: 75 anos de história
Authors: Santiago Ceci Figueiredo de Moura , De Oliveira Aline Gomes de Mello , Faller Ana Luísa Kremer , De Cnop Mara Lima , De Carvalho Rodrigo Cotrim , Accioly Elizabeth
Published: September 2021

No ano de 2021, celebra-se o aniversário de 75 anos do Instituto de Nutrição Josué de Castro (INJC), da Universidade Federal do Rio de Janeiro (UFRJ), criado em 1946 como instituição de ensino e pesquisa da, à época, Universidade do Brasil. O objetivo deste relato, na modalidade “Perspectivas”, foi narrar a trajetória dos cursos do INJC no ensino de graduação, por meio de entrevistas e depoimentos de docentes, análise de documentos, relatórios, atas, anotações do acervo institucional e consultas aos sistemas de informação e armazenamento de dados da UFRJ, livros e resoluções/leis/decretos pertinentes ao tema. O Instituto abriga dois cursos de graduação, sendo o pioneiro o curso de Nutrição, implantado em 1948 para formação de dietistas/nutricionistas, o quarto em nível nacional; e o curso de Gastronomia, implantado em 2011, o primeiro na Região Sudeste do país em instituição pública, na modalidade de graduação, e com proposta pedagógica inovadora. O corpo docente de ambos os cursos apresenta alta qualificação e diversidade de formação, e está envolvido em atividades de ensino, pesquisa e extensão da unidade, ou em parceria com outras instituições, sejam de ensino, organizações sociais, entidades de classe, garantindo a qualidade de formação dos estudantes. Nas comemorações de seu jubileu de brilhante, o INJC reitera seu compromisso social na formação de profissionais tecnicamente competentes e comprometidos com as transformações sociais e na defesa do direito humano à alimentação adequada e saudável.
Tributo ao Instituto de Nutrição Josué de Castro da UFRJ 75 anos de história
Authors: Fernandes Avany , Accioly Elizabeth
Published: September 2021

O presente editorial anuncia, neste número da revista, três manuscritos com o relato das realizações e conquistas do Instituto de Nutrição Josué de Castro (INJC), da Universidade Federal do Rio de Janeiro, no ensino de graduação, pós-graduação e extensão, ao longo de seus 75 anos de criação (1946-2021), como unidade formadora e produtora de conhecimento.Tendo como fundador e primeiro diretor o ilustre professor Josué de Castro, e como missão principal o ensino, implantado em 1948 com a instalação do curso de dietistas, o INJC participou ativamente, em 2009, da criação do segundo curso de Nutrição da UFRJ, no campus Macaé Professor Aloísio Teixeira e, em 2011, implantou o curso de Gastronomia.O ensino de graduação tem forte vínculo com as atividades de extensão, as quais demonstram forte compromisso com as demandas sociais.O INJC é pioneiro ao sediar dois programas de pós-graduação congregando cursos de mestrado acadêmico, mestrado profissional e doutorado, com linhas de pesquisa em parcerias intra e interinstitucionais e com instituições internacionais.Toda essa trajetória é contada, com maior riqueza de detalhes, nos manuscritos que tratam, ainda, das perspectivas e desafios das atividades-fins dessa que é uma das mais tradicionais instituições públicas universitárias, em níveis regional e nacional, na área de Alimentação e Nutrição.O corpo social do INJC, por ocasião das comemorações do jubileu de brilhante da instituição, orgulha-se de sua história de lutas e vitórias conquistadas mesmo diante das adversidades, vivenciadas pela educação pública em diferentes tempos, e reitera seu compromisso com a memória de seu patrono e com a saúde e bem-estar da sociedade brasileira.Agradecemos à equipe editorial da DEMETRA pela oportunidade de contar essa vitoriosa história.E que venham muitos outros jubileus para celebrar!
"Porque a cidade é feita pelas pessoas": uma análise do discurso de uma utopia social contra-hegemônica
Authors: Santos Jouberte Maria Leandro , Mello Sérgio Carvalho Benício de
Published: September 2021

RESUMOA cidade, como é conhecida hoje, é resultado de influências de premissas do paradigma moderno de urbanidade. O conceito de sociedade moderna foi problematizado de modo a entendê-la como, majoritariamente, tecnocrática e liberal. Sendo assim, o objetivo deste paper foi realizar uma explanação crítica do discurso de um movimento social urbano, ou seja, produzir uma Teoria do Discurso da Cidade sob a perspectiva dos Novos Movimentos Sociais. Os dados foram coletados por meio de documentos oficiais, entrevistas e observações. Utiliza-se da teoria pós-estruturalista do discurso de Laclau e Mouffe (2015) para identificar as lógicas sociais, políticas e fantasmáticas que fundamentam e validam as ações do movimento social Direitos Urbanos no período entre 2012 a 2014.
Contratto ed emergenza sanitaria in Italia
Authors: Piraino Fabrizio
Published: September 2021

Questo articolo si propone di analizzare il disastro globale causato dall'epidemia di COVID-19 che ha turbato l'esistenza di quasi tutta l'umanità. Esaminare le significative limitazioni alle libertà individuali e collettive per proteggere la salute pubblica e, in secondo luogo, mitigare il più possibile l'impatto della pandemia sulle attività economiche. L'attenzione dell'articolo si concentrerà esclusivamente sulle norme che impattano sulla disciplina generale delle obbligazioni e dei contratti, tralasciando le importantissime disposizioni in materia di rapporti di lavoro, contratti di mutuo, contratti bancari e assicurativi, ecc. Verificherà fino a che punto la situazione sociale, sanitaria, economica e istituzionale determinata dalla pandemia rappresenti uno stato di emergenza, non dissimile dal dopoguerra, ma che non deve e non può essere considerato uno stato di eccezione.
Prevenção de lesões por pressão nos doentes em unidades de cuidados intensivos
Authors: Ferreira Paulo Alexandre Carvalho , Delphim Livia Moreira , Rodrigues Joana Filipa Cunha , Dias Maria João Da Graça Silva Neves
Published: September 2021

Objetivo: identificar o nível de conhecimento e quais as atitudes dos enfermeiros sobre a prevenção de lesões por pressão nos doentes em unidades de cuidados intensivos. Método: foi realizada pesquisa bibliográfica em abril de 2020, na plataforma EBSCOhost, selecionando as bases de dados Academic Search Complete, CINAHL Complete e MedicLatina, na MEDLINE, através da plataforma Pubmed, na Scopus e na Web of Science. A partir da aplicação dos critérios de inclusão e exclusão, foram analisados oito artigos primários. Resultados: o nível de conhecimento dos enfermeiros demonstrou ser insuficiente e as suas atitudes positivas. Os principais fatores influenciadores foram: idade, anos de experiência profissional, formação/educação e treino na área das lesões por pressão. Conclusão: há necessidade da avaliação do nível de conhecimento dos enfermeiros relativamente à prevenção de lesões por pressão e da criação/implementação de programas educativos.
Teoria crítica racial: direito como definição da condição dos negros
Authors: Batista Waleska Miguel , Almeida Silvio Luiz de
Published: September 2021

Busca-se apresentar que Teoria Crítica Racial surgida a partir das lutas pelos direitos civis nos Estados Unidos contribuiu para evidenciar que o direito nunca foi universal, mas um instrumento de poder do Estado que determina as relações sociais, políticas e econômicas, de tal forma que o racismo é uma relação social normalizada, produzida e reproduzida, apesar de haver leis antirracistas, sendo mantido no Estado Social e Democrático de Direito sem qualquer problema de contradição.  Assim, através de uma revisão bibliográfica de livros e periódicos qualificados sobre a articulação entre raça, racismo e o sistema socioeconômico, conclui-se que  não adianta buscar o combate ao racismo pelo direito enquanto não for compreendido que ele é um poder que utiliza da força para estabelecer a ordem social em que o racismo é normal, ou seja, é incapaz de lutar contra formas de acumulação de capital.