bluuebunny/crossref_metadata_2025 huggingface dataset:
A model-based approach for statistical assessment of detection and localization performance of guided wave–based imaging techniques
Authors: Moriot Jérémy , Quaegebeur Nicolas , Le Duff Alain , Masson Patrice
Published: December 2017

This article aims at providing a framework for assessing the detection and localization performance of guided wave–based structural health monitoring imaging systems. The assessment exploits a damage identification metric providing a diagnostic of the structure from an image of the scatterers generated by the system, allowing detection, localization, and size estimation of the damage. Statistical probability of detection and probability of localization curves are produced based on values of the damage identification metric for several damage sizes and positions. Instead of relying on arduous measurements on a significant number of structures instrumented in the same way, a model-based approach is considered in this article for estimating probability of detection and probability of localization curves numerically. This approach is first illustrated in a simplistic model, which allows characterizing the robustness of the structural health monitoring system for various levels of noise in test signals. An experimental test case using a more realistic case with an artificial damage is then considered for validating the approach. A good agreement between experimental and numerical values of the damage identification metric and derived probability of detection and probability of localization curves is observed.
Role of genetics in peripheral arterial disease outcomes; significance of limb-salvage quantitative locus-1 genes
Authors: Okeke Emmanuel , Dokun Ayotunde O
Published: December 2017

Peripheral artery disease is a major health care problem with significant morbidity and mortality. Humans with peripheral artery disease exhibit two major and differential clinical manifestations – intermittent claudication and critical limb ischemia. Individuals with intermittent claudication or critical limb ischemia have overlapping risk factors and objective measures of blood flow. Hence, we hypothesized that variation in genetic make-up may be an important determinant in the severity of peripheral artery disease. Previous studies have identified polymorphism in genes, contributing to extent of atherosclerosis but much less is known about polymorphisms associated with genes that can influence peripheral artery disease severity. This review outlines some of the progress made up-to-date to unravel the molecular mechanisms underlining differential peripheral artery disease severity. By exploring the recovery phenotype of different mouse strains following experimental peripheral artery disease, our group identified the limb salvage-associated quantitative trait locus 1 on mouse chromosome 7 as the first genetic modifier of perfusion recovery and tissue necrosis phenotypes. Furthermore, a number of genes within LSq-1, such as ADAM12, IL-21Rα, and BAG3 were identified as genetic modifiers of peripheral artery disease severity that function through preservation of endothelial and skeletal muscle cells during ischemia. Taken together, these studies suggest manipulation of limb salvage-associated quantitative trait locus 1 genes show great promise as therapeutic targets in the management of peripheral artery disease.

Impact statement

Peripheral artery disease (PAD) is a major health care problem with significant morbidity and mortality. Individuals with similar atherosclerosis burden do display different severity of disease. This review outlines some of the progress made up-to-date in unraveling the molecular mechanisms underlining differential PAD severity with a focus on the role of the Limb Salvage-associated Quantitative trait locus 1 (LSq-1), a key locus in adaptation to ischemia in PAD.
Biomarkers: Delivering on the expectation of molecularly driven, quantitative health
Authors: Wilson Jennifer L , Altman Russ B
Published: December 2017

Biomarkers are the pillars of precision medicine and are delivering on expectations of molecular, quantitative health. These features have made clinical decisions more precise and personalized, but require a high bar for validation. Biomarkers have improved health outcomes in a few areas such as cancer, pharmacogenetics, and safety. Burgeoning big data research infrastructure, the internet of things, and increased patient participation will accelerate discovery in the many areas that have not yet realized the full potential of biomarkers for precision health. Here we review themes of biomarker discovery, current implementations of biomarkers for precision health, and future opportunities and challenges for biomarker discovery.

Impact statement

Precision medicine evolved because of the understanding that human disease is molecularly driven and is highly variable across patients. This understanding has made biomarkers, a diverse class of biological measurements, more relevant for disease diagnosis, monitoring, and selection of treatment strategy. Biomarkers’ impact on precision medicine can be seen in cancer, pharmacogenomics, and safety. The successes in these cases suggest many more applications for biomarkers and a greater impact for precision medicine across the spectrum of human disease. The authors assess the status of biomarker-guided medical practice by analyzing themes for biomarker discovery, reviewing the impact of these markers in the clinic, and highlight future and ongoing challenges for biomarker discovery. This work is timely and relevant, as the molecular, quantitative approach of precision medicine is spreading to many disease indications.
The Hatfield-system versus the weekly undulating periodised resistance training in trained males
Authors: Antretter Markus , Färber Sebastian , Immler Lorenz , Perktold Matthias , Posch Doris , Raschner Christian , Wachholz Felix , Burtscher Martin
Published: December 2017

The purpose of this study was to compare training adaptations attained during six weeks of using the Hatfield-system and six weeks of the weekly undulating periodisation strength training. Twenty-six recreationally strength trained men were randomly assigned to either a Hatfield-system group ( n = 13; age = 26.8 ± 7.2 years) or a weekly undulating periodisation group ( n = 13; age = 29.2 ± 9.0 years). Anthropometric measures and strength testing were performed before (PRE) and after six weeks (POST) of training. To subjectively quantify the individual’s perception of the physical demands of the intensity of resistance training, a category-ratio scale (CR10) was used by the subjects after each training session. The participants of both groups trained twice a week for six weeks. The Hatfield-system and weekly undulating periodisation programmes used the same exercises, the same total training volume and the same total intensity in these six weeks. The difference between the two programmes was in the distribution within each training phase. The Hatfield-system and weekly undulating periodisation groups trained using a periodised strength programme with all programme variables controlled (e.g. volume and intensity). The Hatfield-system group used a linear not varying intensity, whereas the weekly undulating periodisation group had a varied intensity. The results show that both the Hatfield-system and weekly undulating periodisation groups made significant ( p ≤ 0.05) increases in strength and power. The results of this study indicate that the Hatfield-system model is no more effective than the weekly undulating periodisation model for increasing strength, power and muscle size.
Breaking Down the Administrative Barriers: Condom Availability in the School Setting
Authors: Maziarz Lauren
Published: December 2017

School nurses are at the forefront of health resource decisions, education, and health advocacy in the school setting. When it comes to sex education and condom availability, navigating the politics and controversy surrounding student access and education is not an easy task. Moreover, recent research shows school administrators are not aware of sexual health issues in their district and are not typically supportive of condom availability, limiting evidence-based practice implementation in the school setting. At the district level, school nurses must recognize these challenges and develop plans to promote science-based interventions for students’ sexual health.
Clinical features of paraduodenal hernia
Authors: Wong Yu Jun , Lath Narayan , Eng Alvin Kim Hock , Navasivayam Vikneswaran
Published: December 2017

Paraduodenal hernia (PDH), though uncommon, is a surgical emergency associated with high risk of strangulation and incarceration. Diagnosis of PDH remains challenging due to its non-specific presentation. We report the presentation and management of PDH in our hospital. All PDHs diagnosed from 2003 to 2014 were identified from a hospital database. Diagnosis of PDH was based on either radiological imaging or intraoperative surgical findings. Eight PDHs were identified during the study period. Median age was 48.5 (24–63) years and five occurred in females. All were left-sided PDHs. Six patients experienced recurrent symptoms prior to presentation. The commonest presenting symptoms were recurrent abdominal pain (four patients) and intestinal obstruction (four patients). Five patients were treated conservatively either because they had no obstructive symptoms or they declined surgery. All of them remained well up to a median of 27 (16–45) months’ follow-up. In contrast, three patients with obstructive symptoms underwent surgical repair (laparotomy, hernia repair and adhesiolysis). One patient had sub-acute intestinal obstruction after surgical repair and required re-exploratory surgery. All three PDH patients with obstructive symptoms remained well on follow-up (median 61 (range: 27–114) months) after surgery. In conclusion, PDH is an uncommon cause of intestinal obstruction. A high index of suspicion is required to diagnose PDH.
More than a biomarker: the systemic consequences of heparan sulfate fragments released during endothelial surface layer degradation (2017 Grover Conference Series)
Authors: Oshima Kaori , Haeger Sarah M. , Hippensteel Joseph A. , Herson Paco S. , Schmidt Eric P.
Published: December 2017

Advances in tissue fixation and imaging techniques have yielded increasing appreciation for the glycosaminoglycan‐rich endothelial glycocalyx and its in vivo manifestation, the endothelial surface layer (ESL). Pathological loss of the ESL during critical illness promotes local endothelial dysfunction and, consequently, organ injury. Glycosaminoglycan fragments, such as heparan sulfate, are released into the plasma of animals and humans after ESL degradation and have thus served as a biomarker of endothelial injury. The development of state‐of‐the‐art glycomic techniques, however, has revealed that these circulating heparan sulfate fragments are capable of influencing growth factor and other signaling pathways distant to the site of ESL injury. This review summarizes the current state of knowledge concerning the local (i.e. endothelial injury) and systemic (i.e. para‐ or endocrine) consequences of ESL degradation and identifies opportunities for future, novel investigations.
Predictive value of routine point-of-care cardiac troponin T measurement for prehospital diagnosis and risk-stratification in patients with suspected acute myocardial infarction
Authors: Rasmussen Martin B , Stengaard Carsten , Sørensen Jacob T , Riddervold Ingunn S , Hansen Troels M , Giebner Matthias , Rasmussen Claus-Henrik , Bøtker Hans E , Terkelsen Christian J
Published: December 2017

Objective:

The purpose of this study was to determine the predictive value of routine prehospital point-of-care cardiac troponin T measurement for diagnosis and risk stratification of patients with suspected acute myocardial infarction.

Methods and results:

All prehospital emergency medical service vehicles in the Central Denmark Region were equipped with a point-of-care cardiac troponin T device (Roche Cobas h232) for routine use in all patients with a suspected acute myocardial infarction. During the study period, 1 June 2012–30 November 2015, prehospital point-of-care cardiac troponin T measurements were performed in a total of 19,615 cases seen by the emergency medical service and 18,712 point-of-care cardiac troponin T measurements in 15,781 individuals were matched with an admission. A final diagnosis of acute myocardial infarction was confirmed in 2187 cases and a total of 2150 point-of-care cardiac troponin T measurements (11.0%) had a value ≥50 ng/l, including 966 with acute myocardial infarction (sensitivity: 44.2%, specificity: 92.8%). Patients presenting with a prehospital point-of-care cardiac troponin T value ≥50 ng/l had a one-year mortality of 24% compared with 4.8% in those with values <50 ng/l, log-rank: p<0.001. The following variables showed the strongest association with mortality in multivariable analysis: point-of-care cardiac troponin T≥50 ng/l (hazard ratio 2.10, 95% confidence interval: 1.90–2.33), congestive heart failure (hazard ratio 1.93, 95% confidence interval: 1.74–2.14), diabetes mellitus (hazard ratio 1.42, 95% confidence interval: 1.27–1.59) and age, one-year increase (hazard ratio 1.08, 95% confidence interval: 1.08–1.09).

Conclusions:

Patients with suspected acute myocardial infarction and a prehospital point-of-care cardiac troponin T ≥50 ng/l have a poor prognosis irrespective of the final diagnosis. Routine troponin measurement in the prehospital setting has a high predictive value and can be used to identify high-risk patients even before hospital arrival so that they may be re-routed directly for advanced care at an invasive centre.
A single centre prospective cohort study addressing the effect of a rule-in/rule-out troponin algorithm on routine clinical practice
Authors: Marjot Jack , Kaier Thomas E , Henderson Katherine , Hunter Laura , Marber Michael S , Perera Divaka
Published: December 2017

Aims:

In 2015, the European Society of Cardiology introduced new guidelines for the diagnosis of acute coronary syndromes in patients presenting without persistent ST-segment elevation. These guidelines included the use of high-sensitivity troponin assays for ‘rule-in’ and ‘rule-out’ of acute myocardial injury at presentation (using a ‘0 hour’ blood test). Whilst these algorithms have been extensively validated in prospective diagnostic studies, the outcome of their implementation in routine clinical practice has not been described. The present study describes the change in the patient journey resulting from implementation of such an algorithm in a busy innercity Emergency Department.

Methods and results:

Data were prospectively collected from electronic records at a large Central London hospital over seven months spanning the periods before, during and after the introduction of a new high-sensitivity troponin rapid diagnostic algorithm modelled on the European Society of Cardiology guideline. Over 213 days, 4644 patients had high-sensitivity troponin T measured in the Emergency Department. Of these patients, 40.4% could be ‘ruled-out’ based on the high-sensitivity troponin T concentration at presentation, whilst 7.6% could be ‘ruled-in’. Adoption of the algorithm into clinical practice was associated with a 37.5% increase of repeat high-sensitivity troponin T measurements within 1.5 h for those patients classified as ‘intermediate risk’ on presentation.

Conclusions:

Introduction of a 0 hour ‘rule-in’ and ‘rule-out’ algorithm in routine clinical practice enables rapid triage of 48% of patients, and is associated with more rapid repeat testing in intermediate risk patients.
Kindergarten Teachers’ Understanding on Social Justice: Stories From Indonesia
Authors: Solehuddin Muhammad , Adriany Vina
Published: December 2017

The notion of social justice has often been overlooked in the field of early childhood education because many teachers think that it is too early to introduce the concept to young children. Using multicultural theories, this article attempts to explore kindergarten teachers’ perceptions on the issue of social justice. The method adopted in this research is case study. Thirteen kindergarten teachers from five different schools in three different cities in West Java, Indonesia, are selected as participants. Data are collected through semistructured interviews and analyzed using a grounded approach. Findings of this study highlight the extent to which kindergarten teachers understand issues of social justice in terms of equality of treatment. The findings also illuminate complexities faced by the teachers in negotiating social justice in their teaching. The findings also indicate the need to reform curriculum for teacher training programs to include matters like social justice.
Saccharomyces Boulardii in the Prevention of Pseudomembranous Colitis
Authors: Gosar James G
Published: December 2017

Objective

To evaluate the efficacy of the yeast Saccharomyces boulardii in the prevention of pseudomembranous colitis (PMC).

Data Sources

A MEDLINE search (January 1966–April 2000, updated July 2001) of English-language medical literature was conducted. Key search terms included Saccharomyces boulardii, pseudomembranous colitis, antibiotic-associated diarrhea, and Clostridium difficile. Additional information was obtained from pathophysiology and medical textbooks.

Data Synthesis

S. boulardii is a nonpathogenic yeast used to treat and prevent antibiotic-associated diarrhea, including PMC, a serious, sometimes refractory complication of antibacterial drug therapy. A literature search was conducted to determine its efficacy in preventing PMC.

Conclusions

When administered in combination with standard treatments, S. boulardii does not appear to prevent the first relapse but does appear to reduce subsequent recurrences of probable PMC in patients experiencing antibiotic-associated diarrhea. It has also shown promise as monotherapy in preventing the development of antibiotic-associated diarrhea in patients not experiencing diarrhea. Further well-designed, controlled studies are needed.
Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets
Authors: Quach M. Edward , Dragovich Matthew A. , Chen Wenchun , Syed Anum K. , Cao Wenpeng , Liang Xin , Deng Wei , De Meyer Simon F. , Zhu Guangheng , Peng Jun , Ni Heyu , Bennett Carolyn M. , Hou Ming , Ware Jerry , Deckmyn Hans , Zhang X. Frank , Li Renhao
Published: December 2017

Key Points

Anti-GPIbα antibodies exert a pulling force on platelet GPIbα by crosslinking platelets under shear flow. A mechanical feature of an anti-GPIbα antibody, rather than affinity or epitope, determines ability to induce Fc-independent clearance.
Safety and efficacy of selinexor in relapsed or refractory multiple myeloma and Waldenstrom macroglobulinemia
Authors: Chen Christine , Siegel David , Gutierrez Martin , Jacoby Meagan , Hofmeister Craig C. , Gabrail Nashat , Baz Rachid , Mau-Sorensen Morten , Berdeja Jesus G. , Savona Michael , Savoie Lynn , Trudel Suzanne , Areethamsirikul Nuchanan , Unger T. J. , Rashal Tami , Hanke Tim , Kauffman Michael , Shacham Sharon , Reece Donna
Published: December 2017

Key Points

Selinexor is an oral XPO1 inhibitor with antimyeloma activity. The RP2D is 45 mg/m2 (80 mg) selinexor plus 20 mg dexamethasone given twice weekly.
In Their Own Words: A Qualitative Study of Kenyan Breast Cancer Survivors’ Knowledge, Experiences, and Attitudes Regarding Breast Cancer Genetics
Authors: Lee Siwon , Gedleh Amal , Hill Jessica A. , Qaiser Seemi , Umukunda Yvonne , Odiyo Philip , Kitonyi Grace , Dimaras Helen
Published: December 2017

Introduction

Breast cancer ranks among the most common adult cancers in Kenya. Individuals with a family history of the disease are at increased risk. Mutations most commonly associated with breast cancer affect BRCA1 and BRCA2; mutations in several other genes may also confer breast cancer risk. Genetic testing and counseling can help patients understand their risk and assist clinicians in choosing therapies. We aimed to uncover what patients know, experience, and think with regard to breast cancer genetics in Kenya.

Methods

Participants included breast cancer survivors age > 18 years. Participants completed a demographic questionnaire before participating in focus group discussions to uncover knowledge of, experiences with, and attitudes toward the genetics of breast cancer. Data were analyzed by inductive thematic analysis.

Results

Four focus groups were conducted. Participants had rudimentary knowledge about genetics and cancer development, and although they understood breast cancer could be familial, many suspected environmental factors causing spontaneous disease. They reported limited experience with counseling about genetic risk, perceiving that their physicians were too busy to provide comprehensive information. Many indicated they promoted cancer screening among family to promote early diagnosis. Participants expressed a need for more comprehensive counseling and access to genetic testing, recognizing the added clarity it would bring to their families’ risk of cancer.

Conclusion

Improved communication from health care teams could clarify the risk of cancer for affected families. The introduction of affordable genetic testing and counseling for breast cancer in Kenya is welcomed by survivors.
Η Έννοια του Γεωμετρικού Στερεού: Ψυχολογική, Επιστημολογική και Διδακτική Προσέγγιση
Authors: Μαρκόπουλος (Christos Markopoulos) Χρήστος
Published: December 2017

Στην παρούσα εργασία επιχειρείται η διαμόρφωση ενός θεωρητικού πλαισίου για την δημιουργία ενός περιβάλλοντος διδασκαλίας και μάθησης των γεωμετρικών εννοιών. Πιο συγκεκριμένα, προτείνεται ότι η διδασκαλία και μάθηση των γεωμετρικών εννοιών θα πρέπει να βασίζεται στην ανάλυση αλλά και σύνθεση τριών βασικών προσεγγίσεων, την ψυχολογική, επιστημολογική και διδακτική. Η ψυχολογική θεώρηση περιλαμβάνει την διερεύνηση των γνωστικών αντιλήψεων των μαθητών σχετικά με την έννοια του γεωμετρικού στερεού. Η επιστημολογική ανάλυση της έννοιας συμβάλει στην διερεύνηση και ανάδειξη των επιμέρους χαρακτηριστικών της συγκεκριμένης έννοιας. Τέλος η διδακτική προσέγγιση θέτει τα απαραίτητα χαρακτηριστικά ενός μαθησιακού περιβάλλοντος. Η σύνθεση των τριών προσεγγίσεων κρίνεται απαραίτητη για την δημιουργία ενός περιβάλλοντος διδασκαλίας και μάθησης της έννοιας του γεωμετρικού στερεού. Η διαμόρφωση λοιπόν του συγκεκριμένου θεωρητικού πλαισίου μελέτης της έννοιας του γεωμετρικού στερεού αποτελεί την βάση ανάπτυξης ενός δυναμικού περιβάλλοντος μάθησης. Τα δεδομένα που παρουσιάζονται στην συγκεκριμένη έρευνα περιορίζονται στην ανάλυση ενός διδακτικού επεισοδίου σε μια Στ΄τάξη Δημοτικού όπου εφαρμόστηκε το δυναμικό περιβάλλον μάθησης που αναπτύχθηκε. Τα αποτελέσματα της ανάλυσης του διδακτικού επεισοδίου φανερώνουν ότι η δημιουργία ενός δυναμικού περιβάλλοντος στη σχολική τάξη συμβάλλει στην ανάπτυξη της γεωμετρικής γνώσης και σκέψης των μαθητών σχετικά με την έννοια του γεωμετρικού στερεού.
Εισαγωγικό Σημείωμα
Authors: Κολέζα (Evgenia Koleza) Ευγενία
Published: December 2017

Παρουσίαση του τεύχους
Οι διαισθητικές αντιλήψεις των παιδιών Νηπιαγωγείου, Δημοτικού και Γυμνασίου στο πρόβλημα του αθροίσματος των δύο ζαριών με τη βοήθεια ενός μικρόκοσμου
Authors: Φεσάκης (Giorgos Fesakis) Γιώργος , Καφούση (Sonia Kafoussi) Σόνια , Μαλισιόβα (Eleftheria Malisiova) Ελευθερία
Published: December 2017

Τα παιδιά από νεαρή ηλικία οικοδομούν διαισθητικές αντιλήψεις για τις πιθανότητες, οι οποίες είναι προσαρμόσιμες μέσω κατάλληλων μαθησιακών παρεμβάσεων. Οι ηλεκτρονικοί υπολογιστές με τη δυνατότητα παραγωγής τυχαίων αριθμών και δυναμικών αναπαραστάσεων παρέχουν νέες δυνατότητες στην μάθηση των στοχαστικών εννοιών. Στην εργασία παρουσιάζεται μελέτη περίπτωσης σχετικά με την επίδραση ειδικά σχεδιασμένου λογισμικού παιχνιδιού-μικρόκοσμου στην ανάπτυξη διαισθητικών αντιλήψεων για την έννοια της πιθανότητας. Ο προτεινόμενος μικρόκοσμος βασίζεται στο πρόβλημα του αθροίσματος των δύο ζαριών και η μελέτη της επίδρασης του αφορά σε παιδιά του Νηπιαγωγείου, του Δημοτικού και του Γυμνασίου. Τα πειραματικά ευρήματα υποστηρίζουν τη μαθησιακή αξία του προτεινόμενου μικρόκοσμου στη διάγνωση πρωτογενών και τη διαμόρφωση δευτερογενών διαισθητικών αντιλήψεων για πιθανολογικές έννοιες στο πλαίσιο ελκυστικής μαθησιακής δραστηριότητας.
ΔΙΔΑΣΚΑΛΙΑ ΜΑΘΗΜΑΤΙΚΩΝ ΣΕ ΜΑΘΗΤΕΣ ΜΕ ΝΟΗΤΙΚΗ ΑΝΑΠΗΡΙΑ: ΜΑΘΗΣΗ ΣΕ ΑΥΘΕΝΤΙΚΑ ΠΕΡΙΒΑΛΛΟΝΤΑ ΜΕ ΤΗΝ ΥΠΟΣΤΗΡΙΞΗ ΔΙΚΤΥΟΥ ΓΟΝΕΩΝ ΚΑΙ ΣΧΟΛΕΙΟΥ
Authors: Χρυσικού (Vasiliki Chrysikou) Βασιλική
Published: December 2017

Η παρούσα μελέτη αποτελεί μέρος μιας ευρύτερης έρευνας-δράσης, όπου η διδασκαλία και η μάθηση των μαθηματικών σε μαθητές με νοητική αναπηρία εξετάζονται ως κοινωνικά και πολιτισμικά ενταγμένες διαδικασίες. Ο στόχος της έρευνας είναι να μελετηθεί με ποιον τρόπο η δημιουργία συνεργασίας μεταξύ σχολείου και οικογένειας επηρεάζει την εκπαιδευτική διαδικασία και την ενεργή συμμετοχή των μαθητών σε κοινωνικές δραστηριότητες που συμβάλλουν στην ανάπτυξη της μαθηματικής σκέψης. Οι μαθητές συμμετείχαν σε δραστηριότητες χρηματικών συναλλαγών στην κοινότητα, ενώ παράλληλα ενθαρρύνονταν οι μητέρες να υλοποιήσουν παρόμοιες δράσεις εκτός του σχολικού πλαισίου. Από τα αποτελέσματα αναδεικνύεται ότι οι συζητήσεις με τις μητέρες ενίσχυσαν την επιλογή διδακτικών στόχων και πλαισίων μάθησης που έχουν νόημα για τους μαθητές. Αντίθετα, παράγοντες όπως οι αντιλήψεις των μητέρων για την κοινωνική ένταξη-και κυρίως για το στίγμα των ατόμων με αναπηρία-περιόρισαν την ενεργή συμμετοχή των μαθητών σε δραστηριότητες εκτός του σχολικού πλαισίου.
Η οικονομική λογική της συλλογικής δράσης. Μετα-ηθικά επιχειρήματα σε έναν μη ηθικό κόσμο
Authors: Αλεξανδρόπουλος Στέλιος
Published: December 2017

Δεν διατίθεται περίληψη στα ελληνικά
Οικονομικές συνθήκες και εκλογική συμπεριφορά. Οι κομματικές προτιμήσεις των ανέργων σε περιόδους κρίσης απασχόλησης
Authors: Γεωργιάδου Βασιλική
Published: December 2017

Δεν διατίθεται περίληψη στα ελληνικά
Reason and will in Christianism
Authors: Λίποβατς Θάνος
Published: December 2017

Δεν διατίθεται περίληψη στα ελληνικά
Π. ΠΑΠΑΓΙΑΝΝΗ - Δ. ΚΑΤΣΟΥΛΗ, Οι Χάρτες και η Ευρώπη της Αυτοδιοίκησης, έκδοση ΤΕΔΚΝΑ, Αθήνα 1995,206 σελ.
Authors: Χλέπας Νικόλαος-Κομνηνός
Published: December 2017

Δεν διατίθεται περίληψη / no abstract available
Εναλλακτικές προοπτικές για το μέλλον της Ευρωπαϊκής Ένωσης και οι επιπτώσεις τους στην Κοινοτική πολιτική
Authors: Schmitter Philippe C.
Published: December 2017

Δεν διατίθεται περίληψη στα ελληνικά
Το τέλος του Ψυχρού Πολέμου. Η πτώση της Σοβιετικής Ένωσης, η επανένωση της Γερμανίας και η νέα ευρωπαϊκή αρχιτεκτονική ασφαλείας
Authors: Παπασωτηρίου Χαράλαμπος
Published: December 2017

Δεν διατίθεται περίληψη στα ελληνικά
ΣΤΕΦΑΝΟΣ ΠΕΣΜΑΖΟΓΛΟΥ, Ευρώπη-Τουρκία, τόμ. 1, Αντανακλάσεις και διαθλάσεις. Η στρατηγική των κειμένων τόμ. 2, Ιδεολογία και ρητορεία. Οι αντιλήψεις των τουρκικών πολιτικών δυνάμεων για την Ευρωπαϊκή Κοινότητα, 1975-1993, Αθήνα, Θεμέλιο, 1993,2 τόμοι.
Authors: Λέκκας Παντελής
Published: December 2017

Δεν διατίθεται περίληψη / no abstract available
Οι μετατοπίσεις ψηφοφόρων και η κομματική πειθαρχία στις επαναληπτικές εκλογές της Β ' περιφέρειας Αθηνών
Authors: Χατζηπαντελής Θόδωρος , Ζαφειρόπουλος Κώστας
Published: December 2017

Δεν διατίθεται περίληψη στα ελληνικά
Ο ορθόδοξος χριστιανισμός ως πτυχή της νεοελληνικής πολιτικής κουλτούρας: Κριτικές παρατηρήσεις — σε άρθρο του Θ. Λίποβατς
Authors: Μόσχος Δημήτριος Ν.
Published: December 2017

Δεν διατίθεται περίληψη στα ελληνικά
CLINICAL-ULTRASOUND AND MORPHOLOGIC CHARACTERISTIC OF SEVERE CEREBRAL ISCHEMIA IN NEWBORNS WITH INTRAUTERINE MONO- AND MIXED-RESPIRATORY VIRUS INFECTION
Authors: Кречкивская Ирина , Krechkivskaya Irina , Бородин Евгений , Borodin Evgeniy , Гориков Игорь , Gorikov Igor , Заболотских Татьяна , Zabolotskikh Tat'yana , Баталова Татьяна , Batalova Tatiana , Макаров Игорь , Makarov Igorʹ , Резник Вадим , Reznik Vadim , Гасанова Светлана , Gasanova Svetlana , Лобанова Елизавета , Lobanova Elizaveta
Published: December 2017

The contents of the tumor necrosis factor-alpha (TNF-α) in the serum of the umbilical blood as well as ultrasound and morphologic composition of liquor ways of the brain at severe cerebral ischemia was studied in 103 full-term newborns. The first group included 30 newborns from mothers with a physiologic course of pregnancy (subgroup A) and 20 dead newborns with antenatal anamnesis with uncomplicated virus infection, severe somatic pathology and late gestosis in their mothers during gestation (subgroup B); the second one included 28 newborns with severe cerebral ischemia against intrauterine parainfluenza infection (parainfuenza of 1 and 3 type), and 18 of them died at 3-6th day. The third group consisted of 25 newborns with severe cerebral ischemia against antenatal mixed-respiratory virus infection (parainfluenza of 1 and 3 types and influenza A(H3N2), and 16 of them died at the 2-4 days). It was found out that in the patients of the third group the contents of TNF-α increased till 62.7±2.14 pg/L (in the first and second groups it was 17.6±1.53 pg/L, p1<0.001 and 34.6±2.04 pg/L, respectively, p1<0.001). High values of pro-inflammatory cytokine were caused by the development of system inflammation reaction as a result of direct and mediated influence of some respiratory viruses. In the third group periventricular ischemia was found statistically oftener in 88% of newborns and brain immaturity in 48% of children (in the second group it was 32.1 and 10.7% of newborns, respectively); under pathomorphological study there were revealed big haematomas, subarachnoid haemorrhages, full-blown hyperemia and haematomas in the vascular plexus, karyorhexis, severe perivascular and pericellular edema, vasculitis as well as big focuses of atelectasis, aspirating pneumopathy and pneumonia. This suggested an important role of antenatal mixed-respiratory virus infection and pro-inflammatory cytokines in the improvement of penetrance of blood vessels wall under severe cerebral ischemia in newborns.
PATHOPHYSIOLOGICAL MECHANISMS OF DAMAGING ACTION OF CYTOMEGALOVIRUS INFECTION IN PREGNANCY
Authors: Кытикова Оксана , Kytikova Oksana , Новгородцева Татьяна , Novgorodtseva Tatyana , Петрова Ксения , Petrova Kseniya
Published: December 2017

This systematic review was undertaken to define the urgency of studying the problem of cytomegalovirus infection due to the high frequency of detection of specific antibodies among women of childbearing age and the negative consequences of cytomegalovirus for the fetus and newborn. Despite the advances in modern medicine in the study of etiopathogenesis and diagnosis of cytomegalovirus infection during pregnancy, there is currently no trend towards a reduction in the incidence of obstetric pathologies and fetal damage. Physiological features of the functioning of the immune system in pregnancy are discussed; they create the prerequisites for the emergence or activation of long time persistent cytomegalovirus infection and intrauterine fetal damage. Complications in newborns are much more common if the primary cytomegalovirus infection was detected in the first trimester of pregnancy. Cytomegalovirus infection is accompanied by the development of immunodeficiency, but pathophysiological mechanisms of cytomegalovirus infection with the damaging effect in the first trimester of pregnancy need to be detailed. The pathophysiological mechanism of mismatch of immune regulation in pathological pregnancy and in the presence of cytomegalovirus infection is Th-1/Th-2 imbalance which can serve as a target for the development of pathogenetically oriented therapy of pregnant women with cytomegalovirus infection. It is suggested that the specification of these mechanisms will reduce the frequency of obstetric pathologies.
PLUTONIUM-239 DIOXIDE IN THE LUNG. Report 2: Pathology of the lungs of rats induced by intratracheal injection of plutonium-239 dioxide
Authors: Жорова Е. , Zhorova E. , Беляев И. , Belyaev I. , Калистратова В. , Kalistratova V. , Парфенова И. , Parfenova I. , Тищенко Г. , Tischenko G. , Сапрыкин В. , Saprykin V. , Самойлов А. , Samoylov A.
Published: December 2017

Purpose: The study of lung pathology induced by intratracheal injection of plutonium-239 dioxide and obtaining actual data on the dose-dependent profile of the remote consequences.

Material and methods: The plutonium dioxide was introduced into nonlinear white male rats once intratracheally in the amount of 100 kBq/kg body weight. Experimental animals were observed during their whole life. Radiometric, histoautoradiographical, histological and statistical research methods were used. Indicators of lung pathology were inflammatory, sclerotic, precancerous and neoplastic changes in the lungs.

Results: The calculation of absorbed doses in the lungs showed their variety from 1 to 400 Gr. The paper presents a quantitative analysis of remote lung pathology according to the groups with average absorbed doses from 7 to 306 Gy. The introduction of 239PuO2 significantly increased the frequency of sclerotic changes of the lungs compared with intact rats (11 and 46 % respectively). Tumors were found in the lungs of 20 % of intact rats and of 51 % of the rats that received 239PuO2. Malignant neoplasm of epithelial origin prevailed. They were formed in 9 % of the biological control rats and in 41 % of the rats, carriers of 239PuO2. The dependence of the frequency of pathological changes in the lungs from absorbed dose in the organ was revealed.

Conclusion: A single intratracheal introduction of 239PuO2 has increased the frequency of pathological changes in the lungs of rats compared with intact animals. With the increase of the absorbed dose in the lungs the number of rats with pneumosclerosis, tumors of epithelial origin and multiple tumors has grown. Most indicative are adenocarcinoma and squamous-cell carcinomas. With the increasing of absorbed dose not only the frequency, but a spectrum of tumors varies. Dose response – probability of effect for each type of non-neoplastic and neoplastic pathology has its own character. For tumors of hematopoietic and lymphoid tissue, localized in the lungs, the opposite from tumors of epithelial origin, dependence of the frequency of their formation from the absorbed dose has been revealed.
About Defining the Borders of Radioactive Contamination Zones as a Result of Large Radiation Accidents. Message II. The Principled Approach
Authors: Скоробогатов А. , Skorobogatov A. , Герменчук М. , Germenchuk M. , Симонов А. , Simonov A. , Жукова О. , Zhukova O. , Апанасюк О. , Apanasyuk O.
Published: December 2017

Purpose: Development of methods of establishing the borders of radioactive contamination caused by major radiation accidents.

Material and Methods: Approaches for establishing Radioactive Contamination Zones (RCZ) and defining their borders are proposed based on the notion of a ‘RCZ’s accounting unit’. An area representing a generalized land plot, settlement, forestry and/or water body (i.e. minimum registration units of: the State Cadastre, the Administrative-Territorial Classifiers, the State Forest Registry, and the State Water Register) is proposed to be taken as the RCZ’s accounting unit.

Results: The basic formal procedure provides for identification of the RCZ status for each contaminated area based on the condition of intervention level (criterion) excess by the relevant radiation-situation index. When developing a regulatory document on RCZ establishment, a list of land plots and settlements is drawn up with indication of the RCZ status (rank), the plot’s category and its unique number. Using information about the plot borders, a list of coordinates of characteristic points located at RCZ borders ranked by the RCZ status is made. Such a list may constitute an integral part of the relevant regulatory-and-legal document that establishes RCZ borders.

Conclusions: Taking of a land plot, settlement, forestry or water body as the ‘RCZ’s accounting unit’ enables RCZ’s establishment and determination of their borders using simple formal procedures and a specified number of indices. The RCZs can be presented as cumulative lists of cadastral plots and settlements, whereas their boundaries via the relevant descriptions of boundaries of the plots having different RCZ status.
An economic evaluation of renewable and conventional electricity generation systems in a shopping center using HOMER Pro
Authors: Budes Farid Barrozo , Ochoa Guillermo Valencia , Escorcia Yulineth Cardenas
Published: December 2017

This paper presents the methodology and results of the simulation and
optimization of renewables and non-renewables energy system for supply to a
shopping center as an alternative to the electric grid consumption, so that to
determinate the optimal system. The fundamentals equations used to estimate the
operational costs are presented. The software used to simulate and optimize the
purposed system is HOMER ProÂ®, this software can simulate energy systems
with renewable fractions and optimize those components to obtain the best system
to use. In addition, the renewable systems they have the lowest annual operation
cost and total operation cost in the simulated case study, therefore those systems
should be consider as the better option to take as an alternative to the electrical
grid consumption, but the non-renewable systems could be a great solution if the
problem lies in obtaining an emergency plant, capable of generating large
amounts of energy in a short period of time. Finally, that the renewable electric
generating devices are the better option to use as an alternative to the electric grid
consumption but it is recommended the use of an emergency plant with the final purpose of supply large amounts of energy if the situation requires it and this
emergency plants should be natural gas electric generating devices or diesel
electric generating devices.
Encryption through the use of fractals
Authors: Ortiz Santiago Marquez , Parra Octavio Jose Salcedo , Espitia R. Miguel J.
Published: December 2017

Due to the ever expansion of technology and the development of the world wide
web over the recent decades we have access to a large amount of resources and can
share information with different people regardless of the distance that separates us.
These advancements have different consequences such as the transmission of
information in a correct way, the security that must be assured in this type of
transmissions and the speed with which they are transferred. It is here that
cryptography plays an important role in everyday life, allowing communication to
interact to its fullest with the surrounding environment without fearing from
outsidersâ attacks thanks to the security provided by encrypting plain messages.
Cryptography is the technique that protects documents and data. It uses numbers
and codes to write secret information in documents and confidential data that need
to circulate in the network. To this date, there are different cryptographic
techniques, such as RSA, quantum, asymmetric; they have are all in advanced
research and development stages. This paper aims to discuss the advantages and
disadvantages of using these new types of mathematical methods underlying in
computer security and generating a computational model based on a mathematical model, ensuring a high level of security, complexity, ease of implementation and
more.
The challenges of a comprehensive surgical approach to Blount's disease
Authors: Edwards T. A. , Hughes R. , Monsell F.
Published: December 2017

Purpose

The purpose of this study is to evaluate a surgical technique that aims to address the multi-planar deformities occurring in early onset Blount's disease.

Methods

Seven patients (eight lower limbs) with early onset Blount's disease were treated with a surgical technique that used an external fixator to simultaneously address all aspects of deformity. Presenting radiographic parameters including mechanical axis deviation (MAD), lateral distal femoral angle (LDFA), medial proximal tibial angle (MPTA) and medial plateau angle (MPA) were compared with final follow-up and the unaffected limb. Data was also collected on surgical complications and functional outcomes.

Results

After a mean interval of 4.6 years (2.2 to 9), the MAD of the affected limb improved from 4.85 cm to 1.88 cm, MPTA from 43.58° to 75.46° and MPA from 43.41° to 20.71°. The mean time in the external fixator was 5.6 months (3.5 to 10.4). Recurrence was noted in three patients; two had evidence of nerve injury and one patient had premature fibular consolidation.

Conclusion

The surgical technique described in this study has attempted to address the complex multiaxial deformity that is encountered in Blount's disease. It identifies difficulties and limitations in developing a comprehensive surgical protocol and highlights complications associated with this approach.
A GASTRONOMIA E AS INDICAÇÕES GEOGRÁFICAS COMO FERRAMENTA DE VALORIZAÇÃO DO TERRITÓRIO
Authors: Bizinelli Camila , Manosso Franciele Cristina
Published: December 2017

Cidades, estados e até mesmo regiões vêm se destacando na comercialização e produção de seus produtos e serviços, sendo que a qualidade e a tradição destes estão sendo atribuídas a sua origem. Neste contexto, surgem as Indicações Geográficas (IG), concedidas pelo Instituto Nacional de Propriedade Industrial – INPI. Tais são trabalhadas como um fator relevante para a proteção, bem como, para a diferenciação dos produtos ou serviços de uma determinada localidade. Neste sentido, o presente artigo tem como objetivo analisar de que forma as indicações geográficas estão sendo utilizadas para o fortalecimento da divulgação dos territórios, desde uma perspectiva gastronômica. Para tal, a metodologia de pesquisa baseou-se em pesquisa bibliográfica e documental, tendo como foco central os websites governamentais. Ao que se refere aos resultados da pesquisa, pode-se verificar que um número relevante de indicações geográficas não está sendo divulgado nos sites pertencentes aos municípios, estados e secretarias de turismo correspondentes; sendo assim, destaca-se que o número de sites próprios e presença nas redes sociais são mais significativos.
LAVANDERIA CLASSE A: Um Estudo sobre o Indicador de Desempenho Relave no Processamento de Lavagem do Enxoval Hospitalar
Authors: Acosta Caroline Garaluz , Strassburger Nandri Candida
Published: December 2017

Indicadores de desempenho são formas de dimensionar as características de produtos e processos nas organizações. O objetivo dessa pesquisa é analisar o indicador de desempenho relave da Lavanderia Classe A, localizada no município de Foz do Iguaçu, Paraná, nos anos de 2013, 2014 e 2015, referente ao processamento de lavagem de enxoval hospitalar. Quanto ao método de pesquisa aplicado, face ao problema e aos objetivos, utilizou-se estudo de caso, de corte qualitativo. No estudo, empregaram-se pesquisa bibliográfica e aplicação de questionário junto à sócia proprietária. O resultado sugere que o indicador relave atingiu nos dois primeiros anos de funcionamento 4,48% e 5,01%, respectivamente, o que levou a gestão substituir os produtos utilizados na lavagem do enxoval. No ano de 2015, após a utilização de um produto a base de enzimas, mesmo tendo ocorrido aumento na quantidade de enxoval processado, o indicador apresentou retrocesso, encerrando o ano em 4,66%.
“PARAÍSO NATURAL NAS ÁGUAS”: O Nível de Satisfação dos Consumidores em Relação aos Passeios de Barco à Picãozinho
Authors: Farias Pyetro Pergentino de , Pederneiras Marcleide Maria Macêdo , Silva Keycianne Gomes de Sousa , Silva Elisama Ramos da
Published: December 2017

Os passeios de barco a Picãozinho tiveram origem durante a década de 80, objetivava o lazer das famílias dos pescadores durante finais de semana e feriados. Começou a se difundir após a descoberta do destino como forma de lazer, de forma que, o destino passou a ser comercializado diante a comunidade local e os turistas, o que ocorre até os dias de hoje. O presente artigo teve como objetivo identificar o nível de satisfação dos consumidores em relação aos passeios de barco à Picãozinho. Para isto, realizou-se uma pesquisa quantitativa fazendo uso do método survey, com a aplicação de um questionário, obtendo um total de 131 respondentes. Dentre as principais constatações do estudo, observou-se que a principal motivação que os consumidores possuem para realizar o passeio de barco consiste na experiência em poder conhecer os recifes de corais. Além disso, a maioria dos respondentes apresentou uma elevada satisfação no que se refere à qualidade do passeio.
A EDUCAÇÃO AMBIENTAL ATRAVÉS DO TURISMO PEDAGÓGICO
Authors: Carvalho Aline Beatriz Pacheco , Escobar Letícia Orling Camacho , Cademartori Cristina Vargas
Published: December 2017

Atividades como viagens de estudos e visitas guiadas mostram-se efetivas ao despertar a atenção das pessoas para os problemas decorrentes da degradação do meio ambiente. Neste sentido, o turismo pedagógico, integrando educação e conservação da Natureza, parece ser uma estratégia positiva e capaz de contribuir para a transformação do sujeito a partir da sensibilização para as questões ambientais. Considerando este contexto, o trabalho tem como objetivo apresentar algumas propostas educativas resultantes de um projeto de turismo pedagógico que visou incorporar a educação ambiental em suas práticas. As ações ocorreram entre 2014 e 2017 na sede do Centro de Estudos Ambientais Eco-Terrenão, no município de Glorinha, Rio Grande do Sul. O turismo pedagógico pode, de fato, complementar a educação ambiental ao promover a integração do sujeito com a natureza, através do reconhecimento do meio e da percepção ambiental.
NUEVOS ESCENARIOS PARA LA SEMIÓTICA
Authors: - Revista De Signos y Sentidos
Published: December 2017

NUEVOS ESCENARIOS PARA LA SEMIÓTICA
LOS ENUNCIADORES POLÍTICOS DE LA PROTESTA POR EL AUMENTO DE TARIFAS EN ARGENTINA UN ANÁLISIS HIPERMEDIÁTICO DE UN MOVIMIENTO SOCIAL CONTEMPORÁNEO
Authors: Slimovich Ana
Published: December 2017

En el siguiente trabajo realizamos una articulación de herramientas provenientes de la sociosemiótica de los medios masivos y la teoría de la mediatización de lo político veroniana (Carlón y Scolari, 2009; Steimberg, 1993; Verón, 1987, 1997, 1998 [1995], 2001, 2013), con las derivadas del modelo analítico de la circulación contemporánea (Carlón, 2014, 2015, 2016b; Carlón, Fraticelli, Slimovich y Jiménez, 2016). Asimismo, hacemos una aproximación a un modo de estudio de los movimientos sociales asociando estas conceptualizaciones con el enfoque de la comunicación de Castells (2009, 2012).Nos centramos en el caso del movimiento argentino de protesta por el aumento de tarifas de servicios públicos en 2016. Concluimos en determinar que en el ruidazo de julio de 2016 se conforma un colectivo sociopolítico en un espacio híbrido: se ancla a un hashtag y a la vez ocupa el espacio urbano. Este movimiento se nuclea a partir de un centro de interés: vetar la decisión gubernamental del aumento de tarifas.
FACEBOOK: DE LA INTERACCIÓN AL INTERCAMBIO
Authors: Schaer Francisco
Published: December 2017

El trabajo tiene por objeto presentar un campo de problemas relacionados con el análisis de las redes sociales. Para ello, se adoptarán las dos claves teóricas principales de Eliseo Verón en la Semiosis Social: el concepto de «discurso» y la hipótesis del desfase entre producción y reconocimiento. ¿Es posible «jugar a otro juego» en las redes sociales? ¿Qué implícitos y estrategias de validación plantea el mismo dispositivo de comunicación en la situación que propone? En este trabajo se aborda la evolución de funciones de Facebook para los usuarios, el problema de la construcción de la objetividad a partir de la apertura de diferentes planos de observación y una hipótesis para pensar el vínculo entre las lógicas sistémicas sociales y socioindividuales en esta evolución.