bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Microgroove Shape on Flat Miniature Heat Pipe Efficiency
Authors: Ternet François , Louahlia-Gualous Hasna , Le Masson Stéphane
Published: January 2018

Miniature heat pipes are considered to be an innovative solution able to dissipate high heat with low working fluid fill charge, provide automatic temperature control, and operate with minimum energy consumption and low noise levels. A theoretical analysis on heat pipe thermal performance using Deionized water or n-pentane as the working fluid has been carried out. Analysis on the maximum heat and capillary limitation is conducted for three microgroove cross sections: rectangular, triangular, and trapezoidal. The effect of microgroove height and width, effective length, trapezoidal microgroove inclination angle, and microgroove shape on heat pipe performance is analysed. Theoretical and experimental investigations of the heat pipes’ heat transport limitations and thermal resistances are conducted.
Function Analysis of the Euclidean Distance between Probability Distributions
Authors: Kim Namyong
Published: January 2018

Minimization of the Euclidean distance between output distribution and Dirac delta functions as a performance criterion is known to match the distribution of system output with delta functions. In the analysis of the algorithm developed based on that criterion and recursive gradient estimation, it is revealed in this paper that the minimization process of the cost function has two gradients with different functions; one that forces spreading of output samples and the other one that compels output samples to move close to symbol points. For investigation the two functions, each gradient is controlled separately through individual normalization of each gradient with their related input. From the analysis and experimental results, it is verified that one gradient is associated with the role of accelerating initial convergence speed by spreading output samples and the other gradient is related with lowering the minimum mean squared error (MSE) by pulling error samples close together.
Optimal Control of Wind Farms for Coordinated TSO-DSO Reactive Power Management
Authors: Stock David , Sala Francesco , Berizzi Alberto , Hofmann Lutz
Published: January 2018

The growing importance of renewable generation connected to distribution grids requires an increased coordination between transmission system operators (TSOs) and distribution system operators (DSOs) for reactive power management. This work proposes a practical and effective interaction method based on sequential optimizations to evaluate the reactive flexibility potential of distribution networks and to dispatch them along with traditional synchronous generators, keeping to a minimum the information exchange. A modular optimal power flow (OPF) tool featuring multi-objective optimization is developed for this purpose. The proposed method is evaluated for a model of a real German 110 kV grid with 1.6 GW of installed wind power capacity and a reduced order model of the surrounding transmission system. Simulations show the benefit of involving wind farms in reactive power support reducing losses both at distribution and transmission level. Different types of setpoints are investigated, showing the feasibility for the DSO to fulfill also individual voltage and reactive power targets over multiple connection points. Finally, some suggestions are presented to achieve a fair coordination, combining both TSO and DSO requirements.
A Review of Experiments and Modeling of Gas-Liquid Flow in Electrical Submersible Pumps
Authors: Zhu Jianjun , Zhang Hong-Quan
Published: January 2018

As the second most widely used artificial lift method in petroleum production (and first in produced amount), electrical submersible pump (ESP) maintains or increases flow rate by converting kinetic energy to hydraulic pressure of hydrocarbon fluids. To facilitate its optimal working conditions, an ESP has to be operated within a narrow application window. Issues like gas involvement, changing production rate and high oil viscosity, greatly impede ESP boosting pressure. Previous experimental studies showed that the presence of gas would cause ESP hydraulic head degradation. The flow behaviors inside ESPs under gassy conditions, such as pressure surging and gas pockets, further deteriorate ESP pressure boosting ability. Therefore, it is important to know what parameters govern the gas-liquid flow structure inside a rotating ESP and how it can be modeled. This paper presents a comprehensive review on the key factors that affect ESP performance under gassy flow conditions. Furthermore, the empirical and mechanistic models for predicting ESP pressure increment are discussed. The computational fluid dynamics (CFD)-based modeling approach for studying the multiphase flow in a rotating ESP is explained as well. The closure relationships that are critical to both mechanistic and numerical models are reviewed, which are helpful for further development of more accurate models for predicting ESP gas-liquid flow behaviors.
Acknowledgement to Reviewers of Environments in 2017
Authors:   Environments Editorial Office
Published: January 2018

Peer review is an essential part in the publication process, ensuring that Environments maintains high quality standards for its published papers [...]
Genome-Wide Methylation Patterns in Androgen-Independent Prostate Cancer Cells: A Comprehensive Analysis Combining MeDIP-Bisulfite, RNA, and microRNA Sequencing Data
Authors: Wang Yumin , Qin Tingting , Hu Wangqiang , Chen Binghua , Dai Meijie , Xu Gang
Published: January 2018

This study aimed to investigate the mechanisms underlying the development of the androgen-independent phenotype in prostate cancer. Methylation patterns were detected in androgen-independent and androgen-dependent lymph node carcinoma of the prostate (LNCaP) prostate carcinoma cells based on methylated DNA immunoprecipitation-bisulfite sequencing data and differentially methylated regions (DMRs) were identified. Differentially expressed genes (DEGs) and micro RNAs (miRNAs) with DMRs (named MDEGs and MDEmiRNAs) were identified by combining transcriptome and methylation data, and transcription factor (TF)-DEGs with DMRs in promoter (PMDEGs) and MDEmiRNA-MDEGs networks were constructed. Furthermore, a time-course analysis of gene transcription during androgen deprivation was performed based on microarray data and DMRs, MDEGs, and DEmiRNAs were validated. In total, 18,447 DMRs, 3369 MDEGs, 850 PMDEGs, and 1 MDEmiRNA (miR-429) were identified. A TF-target network (94 PMDEGs and 5 TFs) and a miRNA–target network (172 MDEGs and miR-429) were constructed. Based on the time-course analysis of genes in the networks, NEDD4L and PBX3 were targeted by SOX5, while GNAQ, ANLN, and KIF11 were targeted by miR-429. The expression levels of these genes and miR-429 were confirmed by quantitative real-time polymerase chain reaction. Additionally, 109 DMRs were confirmed using additional public datasets. The regulatory pathways SOX5-NEDD4L/PBX3, miR429-GNAQ/ANLN—RHOA, and miR429-ANLN—KIF11 may participate in the progression of the androgen-independent phenotype in prostate cancer.
Dissection of Myogenic Differentiation Signatures in Chickens by RNA-Seq Analysis
Authors: Li Tingting , Zhang Genxi , Wu Pengfei , Duan Lian , Li Guohui , Liu Qiuhong , Wang Jinyu
Published: January 2018

A series of elaborately regulated and orchestrated changes in gene expression profiles leads to muscle growth and development. In this study, RNA sequencing was used to profile embryonic chicken myoblasts and fused myotube transcriptomes, long non-coding RNAs (lncRNAs), and messenger RNAs (mRNAs) at four stages of myoblast differentiation. Of a total of 2484 lncRNA transcripts, 2288 were long intergenic non-coding RNAs (lincRNAs) and 198 were antisense lncRNAs. Additionally, 1530 lncRNAs were neighboring 2041 protein-coding genes (<10 kb upstream and downstream) and functionally enriched in several pathways related to skeletal muscle development that have been extensively studied, indicating that these genes may be in cis-regulatory relationships. In addition, Pearson’s correlation coefficients demonstrated that 990 lncRNAs and 7436 mRNAs were possibly in trans-regulatory relationships. These co-expressed mRNAs were enriched in various developmentally-related biological processes, such as myocyte proliferation and differentiation, myoblast differentiation, and myoblast fusion. The number of transcripts (906 lncRNAs and 4422 mRNAs) differentially expressed across various stages declined with the progression of differentiation. Then, 4422 differentially expressed genes were assigned to four clusters according to K-means analysis. Genes in the K1 cluster likely play important roles in myoblast proliferation and those in the K4 cluster were likely associated with the initiation of myoblast differentiation, while genes in the K2 and K3 clusters were likely related to myoblast fusion. This study provides a catalog of chicken lncRNAs and mRNAs for further experimental investigations and facilitates a better understanding of skeletal muscle development.
Inhibiting the Physiological Stress Effects of a Sustained Attention Task on Shoulder Muscle Activity
Authors: Wixted Fiona , O’Riordan Cliona , O’Sullivan Leonard
Published: January 2018

Objective: The objective of this study was to investigate if a breathing technique could counteract the effects of hyperventilation due to a sustained attention task on shoulder muscle activity. Background: The trend towards higher levels of automation in industry is increasing. Consequently, manufacturing operators often monitor automated process for long periods of their work shift. Prolonged monitoring work requires sustained attention, which is a cognitive process that humans are typically poor at and find stressful. As sustained attention becomes an increasing requirement of manufacturing operators’ job content, the resulting stress experienced could contribute to the onset of many health problems, including work related musculoskeletal disorders (WRMSDs). Methods: The SART attention test was completed by a group of participants before and after a breathing intervention exercise. The effects of the abdominal breathing intervention on breathing rate, upper trapezius muscle activity and end-tidal CO2 were evaluated. Results: The breathing intervention reduced the moderation effect of end-tidal CO2 on upper trapezius muscle activity. Conclusions: Abdominal breathing could be a useful technique in reducing the effects of sustained attention work on muscular activity. Application: This research can be applied to highly-automated manufacturing industries, where prolonged monitoring of work is widespread and could, in its role as a stressor, be a potential contributor to WRMSDs.
Biointeractions of Herbicide Atrazine with Human Serum Albumin: UV-Vis, Fluorescence and Circular Dichroism Approaches
Authors: Zhu Meiqing , Wang Lijun , Wang Yu , Zhou Jie , Ding Jie , Li Wei , Xin Yue , Fan Shisuo , Wang Zhen , Wang Yi
Published: January 2018

The herbicide atrazine is widely used across the globe, which is a great concern. To investigate its potential toxicity in the human body, human serum albumin (HSA) was selected as a model protein. The interaction between atrazine and HSA was investigated using steady-state fluorescence spectroscopy, synchronous fluorescence spectroscopy, UV-Vis spectroscopy, three-dimensional (3D) fluorescence spectroscopy and circular dichroism (CD) spectroscopy. The intrinsic fluorescence of HSA was quenched by the atrazine through a static quenching mechanism. Fluorescence spectra at two excitation wavelengths (280 and 295 nm) showed that the fluorescence quenched in HSA was mainly contributed to by tryptophan residues. In addition, the atrazine bound to HSA, which induced changes in the conformation and secondary structure of HSA and caused an energy transfer. Thermodynamic parameters revealed that this binding is spontaneous. Moreover, electrostatic interactions play a major role in the combination of atrazine and HSA. One atrazine molecule can only bind to one HSA molecule to form a complex, and the atrazine molecule is bound at site II (subdomain IIIA) of HSA. This study furthers the understanding of the potential effects posed by atrazine on humans at the molecular level.
Residual Inequity: Assessing the Unintended Consequences of New York City’s Clean Heat Transition
Authors: Carrión Daniel , Lee W. , Hernández Diana
Published: January 2018

Energy policies and public health are intimately intertwined. In New York City, a series of policies, known as the Clean Heat Program (CHP), were designed to reduce air pollution by banning residual diesel fuel oils, #6 in 2015 and #4 by 2030. This measure is expected to yield environmental and public health benefits over time. While there is near-universal compliance with the #6 ban, a substantial number of buildings still use #4. In this paper, geographic analysis and qualitative interviews with stakeholders were used to interrogate the CHP’s policy implementation in Northern Manhattan and the Bronx. A total of 1724 (53%) of all residential residual fuel burning buildings are located in this region. Stakeholders reflected mostly on the need for the program, and overall reactions to its execution. Major findings include that government partnerships with non-governmental organizations were effectively employed. However, weaknesses with the policy were also identified, including missed opportunities for more rapid transitions away from residual fuels, unsuccessful outreach efforts, cost-prohibitive conversion opportunities, and (the perception of) a volatile energy market for clean fuels. Ultimately, this analysis serves as a case study of a unique and innovative urban policy initiative to improve air quality and, consequently, public health.
Acknowledgement to Reviewers of IJERPH in 2017
Authors:   IJERPH Editorial Office
Published: January 2018

Peer review is an essential part in the publication process, ensuring that IJERPH maintains high quality standards for its published papers [...]
Acknowledgement to Reviewers of International Journal of Financial Studies in 2017
Authors:   International Journal of Financial Studies Editorial Office
Published: January 2018

Peer review is an essential part in the publication process, ensuring that International Journal of Financial Studies maintains high quality standards for its published papers[...]
Simple Sequence Repeat (SSR) Genetic Linkage Map of D Genome Diploid Cotton Derived from an Interspecific Cross between Gossypium davidsonii and Gossypium klotzschianum
Authors: Kirungu Joy , Deng Yanfeng , Cai Xiaoyan , Magwanga Richard , Zhou Zhongli , Wang Xingxing , Wang Yuhong , Zhang Zhenmei , Wang Kunbo , Liu Fang
Published: January 2018

The challenge in tetraploid cotton cultivars is the narrow genetic base and therefore, the bottleneck is how to obtain interspecific hybrids and introduce the germplasm directly from wild cotton to elite cultivars. Construction of genetic maps has provided insight into understanding the genome structure, interrelationships between organisms in relation to evolution, and discovery of genes that carry important agronomic traits in plants. In this study, we generated an interspecific hybrid between two wild diploid cottons, Gossypium davidsonii and Gossypium klotzschianum, and genotyped 188 F2:3 populations in order to develop a genetic map. We screened 12,560 SWU Simple Sequence Repeat (SSR) primers and obtained 1000 polymorphic markers which accounted for only 8%. A total of 928 polymorphic primers were successfully scored and only 728 were effectively linked across the 13 chromosomes, but with an asymmetrical distribution. The map length was 1480.23 cM, with an average length of 2.182 cM between adjacent markers. A high percentage of the markers on the map developed, and for the physical map of G. raimondii, exhibited highly significant collinearity, with two types of duplication. High level of segregation distortion was observed. A total of 27 key genes were identified with diverse roles in plant hormone signaling, development, and defense reactions. The achievement of developing the F2:3 population and its genetic map constructions may be a landmark in establishing a new tool for the genetic improvement of cultivars from wild plants in cotton. Our map had an increased recombination length compared to other maps developed from other D genome cotton species.
Barriers to the Implementation of Newborn Pulse Oximetry Screening: A Different Perspective
Authors: Kluckow Martin
Published: January 2018

Pulse oximetry screening of the well newborn to assist in the diagnosis of critical congenital heart disease (CCHD) is increasingly being adopted. There are advantages to diagnosing CCHD prior to collapse, particularly if this occurs outside of the hospital setting. The current recommended approach links pulse oximetry screening with the assessment for CCHD. An alternative approach is to document the oxygen saturation as part of a routine set of vital signs in each newborn infant prior to discharge, delinking the measurement of oxygen saturation from assessment for CCHD. This approach, the way that many hospitals which contribute to the Australian New Zealand Neonatal Network (ANZNN) have introduced screening, has the potential benefits of decreasing parental anxiety and expectation, not requiring specific consent, changing the interpretation of false positives and therefore the timing of the test, and removing the pressure to perform an immediate echocardiogram if the test is positive. There are advantages of introducing a formal screening program, including the attainment of adequate funding and a universal approach, but the barriers noted above need to be dealt with and the process of acceptance by a national body as a screening test can take many years.
Acknowledgement to Reviewers of Infrastructures in 2017
Authors:   Infrastructures Editorial Office
Published: January 2018

Peer review is an essential part in the publication process, ensuring that Infrastructures maintains high quality standards for its published papers [...]
Developing a Zener–Hollomon Based Forming Limit Surface for Warm Sheet Forming of Magnesium Alloy
Authors: Sheng Z. , Mallick P.
Published: January 2018

The concept of Zener–Hollomon (Z) based Forming Limit Surface (Z-FLS)—which has minor strain, major strain, and ln(Z) as its three axes—was initially proposed in a previous study. In the Z-FLS diagram, strain rate and temperature effects on the major limit strain are reflected by ln(Z). In the current study, the concept of Z-FLS is revisited to provide a practical approach to construct Z-FLS. A Z-FLS then is constructed for magnesium alloy AZ31B sheet material using available experimental forming limit curves. The constructed Z-FLS is used to identify fracture in a non-isothermal warm cup forming process, which was modeled as a coupled thermo-mechanical process. Based on the Z-FLS, the determined limiting draw ratio (LDR) matches well with the published experimental results.
Acknowledgement to Reviewers of Journal of Fungi in 2017
Authors:   Journal of Fungi Editorial Office
Published: January 2018

Peer review is an essential part in the publication process, ensuring that Journal of Fungi maintains high quality standards for its published papers.[...]
Acknowledgement to Reviewers of Lubricants in 2017
Authors:   Lubricants Editorial Office
Published: January 2018

Peer review is an essential part in the publication process, ensuring that Lubricants maintains high quality standards for its published papers.[...]
The Effects of a Macromolecular Charring Agent with Gas Phase and Condense Phase Synergistic Flame Retardant Capability on the Properties of PP/IFR Composites
Authors: Chen Hongda , Wang Jihui , Ni Aiqing , Ding Anxin , Han Xia , Sun Ziheng
Published: January 2018

In order to improve the efficiency of intumescent flame retardants (IFRs), a novel macromolecular charring agent named poly(ethanediamine-1,3,5-triazine-p-4-amino-2,2,6,6-tetramethylpiperidine) (PETAT) with gas phase and condense phase synergistic flame-retardant capability was synthesized and subsequently dispersed into polypropylene (PP) in combination with ammonium polyphosphate (APP) via a melt blending method. The chemical structure of PETAT was investigated by Fourier transform infrared spectroscopy (FTIR), and 1H nuclear magnetic resonance (NMR) spectroscopy. Thermal properties of the PETAT and IFR systems were tested by thermogravimetric-derivative thermogravimetric analysis (TGA-DTG) and thermogravimetry–Fourier transform infrared spectroscopy (TG-FTIR). The mechanical properties, thermal stability, flame-retardant properties, water resistance, and structures of char residue in flame-retardant composites were characterized using tensile and flexural strength property tests, TGA, limiting oxygen index (LOI) values before and after soaking, underwritten laboratory-94 (UL-94) vertical burning test, cone calorimetric test (CCT), scanning electron microscopy with energy dispersive X-ray spectrometry (SEM-EDXS), and FTIR. The results indicated that PETAT was successfully synthesized, and when the ratio of APP to PETAT was 2:1 with 25 wt % loading, the novel IFR system could reduce the deterioration of tensile strength and enhance the flexural strength of composites. Meanwhile, the flame-retardant composite was able to pass the UL-94 V-0 rating with an LOI value of 30.3%, and the peak of heat release rate (PHRR), total heat release (THR), and material fire hazard values were considerably decreased compared with others. In addition, composites also exhibited excellent water resistance properties compared with traditional IFR composites. SEM-EDXS and FTIR analyses of the char residues, as well as TG-FTIR analyses of IFR were used to investigate the flame-retardant mechanism of the APP/PETAT IFR system. The results indicated that the efficient flame retardancy of PP/IFR composites could be attributed to the synergism of the free radical-quenching and char layer-protecting mechanisms in the gas phase and condense phase, respectively.
Discrete Optimization of Internal Part Structure via SLM Unit Structure-Performance Database
Authors: Tang Li , Zhang Qingbiao , Liang Keshan , Zhao Xiqing , Zhang Zhixiong
Published: January 2018

The structural optimization of the internal structure of parts based on three-dimensional (3D) printing has been recognized as being important in the field of mechanical design. The purpose of this paper is to present a creation of a unit structure-performance database based on the selective laser melting (SLM), which contains various structural units with different functions and records their structure and performance characteristics so that we can optimize the internal structure of parts directly, according to the database. The method of creating the unit structure-performance database was introduced in this paper and several structural units of the unit structure-performance database were introduced. The bow structure unit was used to show how to create the structure-performance database of the unit as an example. Some samples of the bow structure unit were designed and manufactured by SLM. These samples were tested in the WDW-100 compression testing machine to obtain their performance characteristics. After this, the paper collected all data regarding unit structure parameters, weight, performance characteristics, and other data; and, established a complete set of data from the bow structure unit for the unit structure-performance database. Furthermore, an aircraft part was reconstructed conveniently to be more lightweight according to the unit structure-performance database. Its weight was reduced by 36.8% when compared with the original structure, while the strength far exceeded the requirements.
In Situ Spectroscopic Analysis of the Carbothermal Reduction Process of Iron Oxides during Microwave Irradiation
Authors: Fukushima Jun , Takizawa Hirotsugu
Published: January 2018

The effects of microwave plasma induction and reduction on the promotion of the carbothermal reduction of iron oxides (α-Fe2O3, γ-Fe2O3, and Fe3O4) are investigated using in situ emission spectroscopy measurements during 2.45 GHz microwave processing, and the plasma discharge (such as CN and N2) is measured during microwave E-field irradiation. It is shown that CN gas or excited CN molecules contribute to the iron oxide reduction reactions, as well as to the thermal reduction. On the other hand, no plasma is generated during microwave H-field irradiation, resulting in thermal reduction. Magnetite strongly interacts with the microwave H-field, and the reduction reaction is clearly promoted by microwave H-field irradiation, as well as thermal reduction reaction.
Acknowledgement to Reviewers of Microorganisms in 2017
Authors:   Microorganisms Editorial Office
Published: January 2018

Peer review is an essential part in the publication process, ensuring that Microorganisms maintains high quality standards for its published papers [...]
Dinuclear Nickel(I) and Palladium(I) Complexes for Highly Active Transformations of Organic Compounds
Authors: Inatomi Takahiro , Koga Yuji , Matsubara Kouki
Published: January 2018

In typical catalytic organic transformations, transition metals in catalytically active complexes are present in their most stable valence states, such as palladium(0) and (II). However, some dimeric monovalent metal complexes can be stabilized by auxiliary ligands to form diamagnetic compounds with metal–metal bonding interactions. These diamagnetic compounds can act as catalysts while retaining their dimeric forms, split homolytically or heterolytically into monomeric forms, which usually have high activity, or in contrast, become completely deactivated as catalysts. Recently, many studies using group 10 metal complexes containing nickel and palladium have demonstrated that under specific conditions, the active forms of these catalyst precursors are not mononuclear zerovalent complexes, but instead dinuclear monovalent metal complexes. In this mini-review, we have surveyed the preparation, reactivity, and the catalytic processes of dinuclear nickel(I) and palladium(I) complexes, focusing on mechanistic insights into the precatalyst activation systems and the structure and behavior of nickel and palladium intermediates.
Enantiomeric Resolution and Docking Studies of Chiral Xanthonic Derivatives on Chirobiotic Columns
Authors: Phyo Ye‛ , Cravo Sara , Palmeira Andreia , Tiritan Maria , Kijjoa Anake , Pinto Madalena , Fernandes Carla
Published: January 2018

A systematic study of enantioresolution of a library of xanthonic derivatives, prepared “in-house”, was successfully carried out with four commercially available macrocyclic glycopeptide-based columns, namely ChirobioticTM T, ChirobioticTM R, ChirobioticTM V and ChirobioticTM TAG. Evaluation was conducted in multimodal elution conditions: normal-phase, polar organic, polar ionic and reversed-phase. The effects of the mobile phase composition, the percentage of organic modifier, the pH of the mobile phase, the nature and concentration of different mobile phase additives on the chromatographic parameters are discussed. ChirobioticTM T and ChirobioticTM V, under normal-phase and reversed-phase modes, respectively, presented the best chromatographic parameters. Considering the importance of understanding the chiral recognition mechanisms associated with the chromatographic enantioresolution, and the scarce data available for macrocyclic glycopeptide-based columns, computational studies by molecular docking were also carried out.
The Chemistry of Alliums
Authors: Gruhlke Martin , Slusarenko Alan
Published: January 2018

Physiologically active sulfur-containing compounds produced by Allium spp. have long fascinated chemists, biochemists, and biologists.[...]
α-Glucosidase Inhibition and Antibacterial Activity of Secondary Metabolites from the Ecuadorian Species Clinopodium taxifolium (Kunth) Govaerts
Authors: Morocho Vladimir , Valle Andrea , García Jessica , Gilardoni Gianluca , Cartuche Luis , Suárez Alírica
Published: January 2018

The phytochemical investigation of both volatile and fixed metabolites of Clinopodium taxifolium (Kunth) Govaerts (Lamiaceae) was performed for the first time. It allowed the isolation and characterization of the essential oil and six known compounds: carvacrol (1), squalane (2), uvaol (3), erythrodiol (4), ursolic acid (5), and salvigenin (6). Their structures were identified and characterized by Nuclear Magnetic Resonance (NMR) and Gas Chromatography coupled to Mass Spectroscopy (GC-MS), and corroborated by literature. The essential oil of the leaves was obtained by hydrodistillation in two different periods and analyzed by GC-MS and GC coupled to Flame Ionization Detector (GC-FID). A total of 54 compounds were detected, of which 42 were identified (including trace constituents). The major constituents were carvacrol methyl ether (18.9–23.2%), carvacrol (13.8–16.3%) and, carvacryl acetate (11.4–4.8%). The antibacterial activities were determined as Minimum Inhibition Concentration (MIC) against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Pseudomonas aeruginosa and Micrococcus luteus. The hexane and methanol extracts exhibited activity only against Klebsiella pneumoniae (250 and 500 μg/mL respectively), while the ethyl acetate extract was inactive. The hypoglycemic activity was evaluated by the in vitro inhibition of α-glucosidase. The ethyl acetate (EtOAc) extract showed strong inhibitory activity with IC50 = 24.88 µg/mL, however methanolic and hexanic extracts showed weak activity. As a pure compound, only ursolic acid showed a strong inhibitory activity, with IC50 = 72.71 μM.
Nutritional Status of Bariatric Surgery Candidates
Authors: Al-Mutawa Aliaa , Anderson Alfred , Alsabah Salman , Al-Mutawa Mohammad
Published: January 2018

Obesity is a global epidemic affecting populations globally. Bariatric surgery is an effective treatment for morbid obesity, and has increased dramatically. Bariatric surgery candidates frequently have pre-existing nutritional deficiencies that might exacerbate post-surgery. To provide better health care management pre- and post-bariatric surgery, it is imperative to establish the nutritional status of prospective patients before surgery. The aim of this study was to assess and provide baseline data on the nutritional status of bariatric candidates. A retrospective study was conducted on obese patients who underwent bariatric surgery from 2008 to 2015. The medical records of 1538 patients were reviewed for this study. Pre-operatively, the most commonly observed vitamin deficiencies were Vitamin D (76%) and Vitamin B12 (16%). Anemia and iron status parameters were low in a considerable number of patients before surgery, as follows: hemoglobin 20%, mean corpuscular volume (MCV) 48%, ferritin 28%, serum iron 51%, and transferrin saturation 60%. Albumin and transferrin were found to be low in 10% and 9% of the patients, respectively, prior to surgery. In addition to deficiencies, a great number of patients had hypervitaminosis pre-operatively. Excess levels of Vitamin B6 (24%) was the most remarkable. The findings in this study advocate a close monitoring and tailored supplementation pre- and post-bariatric surgery.
Food Addiction and Binge Eating: Lessons Learned from Animal Models
Authors: Novelle Marta , Diéguez Carlos
Published: January 2018

The feeding process is required for basic life, influenced by environment cues and tightly regulated according to demands of the internal milieu by regulatory brain circuits. Although eating behaviour cannot be considered “addictive” under normal circumstances, people can become “addicted” to this behaviour, similarly to how some people are addicted to drugs. The symptoms, cravings and causes of “eating addiction” are remarkably similar to those experienced by drug addicts, and both drug-seeking behaviour as eating addiction share the same neural pathways. However, while the drug addiction process has been highly characterised, eating addiction is a nascent field. In fact, there is still a great controversy over the concept of “food addiction”. This review aims to summarize the most relevant animal models of “eating addictive behaviour”, emphasising binge eating disorder, that could help us to understand the neurobiological mechanisms hidden under this behaviour, and to improve the psychotherapy and pharmacological treatment in patients suffering from these pathologies.
RNA-Seq as an Emerging Tool for Marine Dinoflagellate Transcriptome Analysis: Process and Challenges
Authors: Akbar Muhamad , Ahmad Asmat , Usup Gires , Bunawan Hamidun
Published: January 2018

Dinoflagellates are the large group of marine phytoplankton with primary studies interest regarding their symbiosis with coral reef and the abilities to form harmful algae blooms (HABs). Toxin produced by dinoflagellates during events of HABs cause severe negative impact both in the economy and health sector. However, attempts to understand the dinoflagellates genomic features are hindered by their complex genome organization. Transcriptomics have been employed to understand dinoflagellates genome structure, profile genes and gene expression. RNA-seq is one of the latest methods for transcriptomics study. This method is capable of profiling the dinoflagellates transcriptomes and has several advantages, including highly sensitive, cost effective and deeper sequence coverage. Thus, in this review paper, the current workflow of dinoflagellates RNA-seq starts with the extraction of high quality RNA and is followed by cDNA sequencing using the next-generation sequencing platform, dinoflagellates transcriptome assembly and computational analysis will be discussed. Certain consideration needs will be highlighted such as difficulty in dinoflagellates sequence annotation, post-transcriptional activity and the effect of RNA pooling when using RNA-seq.
The Impact of Eclipsing GNSS Satellites on the Precise Point Positioning
Authors: Cao Xinyun , Zhang Shoujian , Kuang Kaifa , Liu Tianjun , Gao Kang
Published: January 2018

When satellites enter into the noon maneuver or the shadow crossing regimes, the actual attitudes will depart from their nominal values. If improper attitude models are used, the induced-errors due to the wind-up effect and satellite antenna PCO (Phase Center Offset) will deteriorate the positioning accuracy. Because different generations of satellites adopt different attitude control models, the influences on the positioning performances deserve further study. Consequently, the impact of three eclipsing strategies on the single-system and multi-GNSS (Global Navigation Satellite System) Precise Point Positioning (PPP) are analyzed. According to the results of the eclipsing monitor, 65 globally distributed MGEX (Multi-GNSS EXperiment) stations for 31-day period in July 2017 are selected to perform G/R/E/C/GR/GREC PPP in both static and kinematic modes. The results show that the influences of non-nominal attitudes are related to the magnitude of the PCO values, maximum yaw angle differences, the duration of maneuver, the value of the sun angle and the satellite geometric strength. For single-system, using modeled attitudes rather than the nominal ones will greatly improve the positioning accuracy of GLONASS-only and BDS-only PPP while slightly contributions to the GPS-only and GALILEO-only PPP. Deleting the eclipsing satellites may sometimes induce a longer convergence time and a worse solution due to the poor satellite geometry, especially for GLONASS kinematic PPP when stations are located in the low latitude and BDS kinematic PPP. When multi-GNSS data are available, especially four navigation systems, the accuracy improvements of using the modeled attitudes or deleting eclipsing satellites are non-significant.
Golay Complementary Waveforms in Reed–Müller Sequences for Radar Detection of Nonzero Doppler Targets
Authors: Zhu Jiahua , Wang Xuezhi , Huang Xiaotao , Suvorova Sofia , Moran Bill
Published: January 2018

Golay complementary waveforms can, in theory, yield radar returns of high range resolution with essentially zero sidelobes. In practice, when deployed conventionally, while high signal-to-noise ratios can be achieved for static target detection, significant range sidelobes are generated by target returns of nonzero Doppler causing unreliable detection. We consider signal processing techniques using Golay complementary waveforms to improve radar detection performance in scenarios involving multiple nonzero Doppler targets. A signal processing procedure based on an existing, so called, Binomial Design algorithm that alters the transmission order of Golay complementary waveforms and weights the returns is proposed in an attempt to achieve an enhanced illumination performance. The procedure applies one of three proposed waveform transmission ordering algorithms, followed by a pointwise nonlinear processor combining the outputs of the Binomial Design algorithm and one of the ordering algorithms. The computational complexity of the Binomial Design algorithm and the three ordering algorithms are compared, and a statistical analysis of the performance of the pointwise nonlinear processing is given. Estimation of the areas in the Delay–Doppler map occupied by significant range sidelobes for given targets are also discussed. Numerical simulations for the comparison of the performances of the Binomial Design algorithm and the three ordering algorithms are presented for both fixed and randomized target locations. The simulation results demonstrate that the proposed signal processing procedure has a better detection performance in terms of lower sidelobes and higher Doppler resolution in the presence of multiple nonzero Doppler targets compared to existing methods.
An Enhanced Secure Identity-Based Certificateless Public Key Authentication Scheme for Vehicular Sensor Networks
Authors: Li Congcong , Zhang Xi , Wang Haiping , Li Dongfeng
Published: January 2018

Vehicular sensor networks have been widely applied in intelligent traffic systems in recent years. Because of the specificity of vehicular sensor networks, they require an enhanced, secure and efficient authentication scheme. Existing authentication protocols are vulnerable to some problems, such as a high computational overhead with certificate distribution and revocation, strong reliance on tamper-proof devices, limited scalability when building many secure channels, and an inability to detect hardware tampering attacks. In this paper, an improved authentication scheme using certificateless public key cryptography is proposed to address these problems. A security analysis of our scheme shows that our protocol provides an enhanced secure anonymous authentication, which is resilient against major security threats. Furthermore, the proposed scheme reduces the incidence of node compromise and replication attacks. The scheme also provides a malicious-node detection and warning mechanism, which can quickly identify compromised static nodes and immediately alert the administrative department. With performance evaluations, the scheme can obtain better trade-offs between security and efficiency than the well-known available schemes.
In Vitro Bioavailability Study of an Antiviral Compound Enisamium Iodide
Authors: Haltner-Ukomadu Eleonore , Gureyeva Svitlana , Burmaka Oleksii , Goy Andriy , Mueller Lutz , Kostyuk Grygorii , Margitich Victor
Published: January 2018

An investigation into the biopharmaceutics classification and a study of the in vitro bioavailability (permeability and solubility) of the antiviral compound enisamium iodide (4-(benzylcarbamoyl)-1-methylpyridinium iodide) were carried out. The solubility of enisamium iodide was determined in four different buffers. Apparent intestinal permeability (Papp) of enisamium iodide was assessed using human colon carcinoma (Caco-2) cells at three concentrations. The solubility of enisamium iodide in four buffer solutions from pH 1.2 to 7.5 is about 60 mg/mL at 25 °C, and ranges from 130 to 150 mg/mL at 37 °C, depending on the pH. Based on these results, enisamium iodide can be classified as highly soluble. Enisamium iodide demonstrated low permeability in Caco-2 experiments in all tested concentrations of 10–100 μM with permeability coefficients between 0.2 × 10−6 cm s−1 and 0.3 × 10−6 cm s−1. These results indicate that enisamium iodide belongs to class III of the Biopharmaceutics Classification System (BCS) due to its high solubility and low permeability. The bioavailability of enisamium iodide needs to be confirmed in animal and human studies.
Phosphorus Availability in Wheat, in Volcanic Soils Inoculated with Phosphate-Solubilizing Bacillus thuringiensis
Authors: Delfim Jorge , Schoebitz Mauricio , Paulino Leandro , Hirzel Juan , Zagal Erick
Published: January 2018

The use of phosphate solubilizing bacteria (PSB) is an ecological strategy that allows for increasing the availability of phosphorus (P) in soil. The objective of this study was to evaluate P availability in wheat, in soils derived from volcanic ash (Andisol and Ultisol,) and inoculated with phosphate-solubilizing Bacillus thuringiensis, the experiment was conducted in pots under greenhouse conditions using a completely randomized design. Wheat plants were inoculated and re-inoculated at 20 and 46 days after sowing (DAS), respectively, with B. thuringiensis; and, soil and plant sampling was performed after 46, 66, and 87 days based on the Zadoks growth scale (Z). The inoculation resulted in an 11% increase in P of the rhizosphere at Z46 (Ultisol), P also increased 34% and 67% in aerial tissues at Z46 (Andisol and Ultisol), respectively, while an increase of 75% was observed in root tissues at Z87 (Ultisol). Similarly, the inoculation resulted in increases in acid phosphatase activity (Andisol), soil microbial biomass (Andisol and Ultisol), and root biomass in plants (Ultisol), without achieving increase of the aerial biomass of the plants. The phosphate solubilizing B. thuringiensis strain showed some positive, but also negative effects in soils and plants, depending on the soil.
Exploring Institutional Transformations to Address High-End Climate Change in Iberia
Authors: Tàbara Joan , Cots Francesc , Pedde Simona , Hölscher Katharina , Kok Kasper , Lovanova Anastasia , Capela Lourenço Tiago , Frantzeskaki Niki , Etherington John
Published: January 2018

Either meeting the UNFCCC Paris agreement to limit global average warming below the 2–1.5 °C threshold, or going beyond it entails huge challenges in terms of institutional innovation and transformation. This research describes a participatory integrated assessment process aimed at exploring the options, opportunities, necessary capacities and implications for institutional co-operation and innovation in the Iberian Peninsula under High-End Climate Change (HECC). Using in-depth interviews and a novel participatory research approach, different scenario narratives and pathways about the future of Iberia have been identified using Shared Socio-economic Pathways (SSPs). Special attention is given to the knowledge and policy options needed to implement cross-border organizational changes and co-operation mechanisms that would support the Integrated Climate Governance of the Tagus and Guadiana river basins. We show that a wealth of institutional innovation pathways and specific options and solutions exist not only to reduce GHG emissions (mitigation) and the negative impacts of climate change (adaptation), but, above all, to generate new forms of social-ecological system interactions aligned with sustainability (transformation). In particular, and depending on which scenario contexts unfold in the future in Iberia, different kinds of institutional and governance capacities and clusters of solutions may be needed in order to achieve transformation.
The Variety of 7-Dimensional 2-Step Nilpotent Lie Algebras
Authors: Alvarez María
Published: January 2018

In this note, we consider degenerations between complex 2-step nilpotent Lie algebras of dimension 7 within the variety N 7 2 . This allows us to obtain the rigid algebras in N 7 2 , whose closures give the irreducible components of the variety.
Bottled Water or Tap Water? A Comparative Study of Drinking Water Choices on University Campuses
Authors: Qian Neng
Published: January 2018

A cross-regional comparative study was conducted to survey the drinking behaviors of university students, in Singapore, Hong Kong, and Macau. In particular, I tested students’ preference for bottled water over filtered tap water, in a context where the latter option is widely accessible, free of charge, and meets drinking standards. It was found that Singapore has a relatively low rate of bottled water consumption within the young population of university students, while in Hong Kong and Macau one-fourth of the students still drink bottled water more frequently than tap water. Using the Theory of Planned Behavior framework, the perceptions and factors that determine the choices were studied. In terms of determinants of the drinking water choices, “Safety and Hygiene” and “Convenience and Availability” ranked highest for all three regions. “Taste”, “Price”, and “Personal and Family Habits” were valued next by different subsamples. Respondents from Singapore rated relatively high in the accessibility of filtered tap water, safety of tap water transfer, and trust in government, and these factors are considerably significant in driving the result of having the lowest consumption of bottle water on campus. Gender and the behaviors of students who stay in campus dorms were also explored.
Acknowledgement to Reviewers of Water in 2017
Authors:   Water Editorial Office
Published: January 2018

Peer review is an essential part in the publication process, ensuring that Water maintains high quality standards for its published papers [...]
Effects of Aeration, Vegetation, and Iron Input on Total P Removal in a Lacustrine Wetland Receiving Agricultural Drainage
Authors: Zou Yuanchun , Zhang Linlin , Wang Luying , Zhang Sijian , Yu Xiaofei
Published: January 2018

Utilizing natural wetlands to remove phosphorus (P) from agricultural drainage is a feasible approach of protecting receiving waterways from eutrophication. However, few studies have been carried out about how these wetlands, which act as buffer zones of pollutant sinks, can be operated to achieve optimal pollutant removal and cost efficiency. In this study, cores of sediments and water were collected from a lacustrine wetland of Lake Xiaoxingkai region in Northeastern China, to produce a number of lab-scale wetland columns. Ex situ experiments, in a controlled environment, were conducted to study the effects of aeration, vegetation, and iron (Fe) input on the removal of total P (TP) and values of dissolved oxygen (DO) and pH of the water in these columns. The results demonstrated the links between Fe, P and DO levels. The planting of Glyceria spiculosa in the wetland columns was found to increase DO and pH values, whereas the Fe:P ratio was found to inversely correlate to the pH values. The TP removal was the highest in aerobic and planted columns. The pattern of temporal variation of TP removals matched first-order exponential growth model, except for under aerobic condition and with Fe:P ratio of 10:1. It was concluded that Fe introduced into a wetland by either surface runoff or agricultural drainage is beneficial for TP removal from the overlying water, especially during the growth season of wetland vegetation.