bluuebunny/crossref_metadata_2025 huggingface dataset:
A system-oriented strategy to enhance electron production of Synechocystis sp. PCC6803 in bio-photovoltaic devices: experimental and modeling insights
Authors: Firoozabadi Hossein , Mardanpour Mohammad Mahdi , Motamedian Ehsan
Published: March 2021

Bio-photovoltaic devices (BPVs) harness photosynthetic organisms to produce bioelectricity in an eco-friendly way. However, their low energy efficiency is still a challenge. A comprehension of metabolic constraints can result in finding strategies for efficiency enhancement. This study presents a systemic approach based on metabolic modeling to design a regulatory defined medium, reducing the intracellular constraints in bioelectricity generation of Synechocystis sp. PCC6803 through the cellular metabolism alteration. The approach identified key reactions that played a critical role in improving electricity generation in Synechocystis sp. PCC6803 by comparing multiple optimal solutions of minimal and maximal NADH generation using two criteria. Regulatory compounds, which controlled the enzyme activity of the key reactions, were obtained from the BRENDA database. The selected compounds were subsequently added to the culture media, and their effect on bioelectricity generation was experimentally assessed. The power density curves for different culture media showed the BPV fed by Synechocystis sp. PCC6803 suspension in BG-11 supplemented with NH4Cl achieved the maximum power density of 148.27 mW m-2. This produced power density was more than 40.5-fold of what was obtained for the BPV fed with cyanobacterial suspension in BG-11. The effect of the activators on BPV performance was also evaluated by comparing their overpotential, maximum produced power density, and biofilm morphology under different conditions. These findings demonstrated the crucial role of cellular metabolism in improving bioelectricity generation in BPVs.
Association of variants m.T16172C and m.T16519C in whole mtDNA sequences with high altitude pulmonary edema in Han Chinese lowlanders
Authors: Wang Yan , Huang Xuewen , Peng Fujun , Han Huiling , Gu Yanan , Liu Xin , Feng Zhichun
Published: March 2021

Background: High altitude pulmonary edema (HAPE) is a hypoxia-induced non-cardiogenic pulmonary edema that typically occurred in un-acclimatized lowlanders, which inevitably leads to life-threatening consequences. Apart from multiple factors involved, the genetic factors also play an important role in the pathogenesis of HAPE. So far, researchers put more energy into the nuclear genome and HAPE, and ignored the relationship between the mitochondrion DNA (mtDNA) variants and HAPE susceptibility. Methods: We recruited a total of 366 individuals including 181 HAPE patients and 185 healthy or non-HAPE populations through two times. The first time, 49 HAPE patients and 58 non-HAPE cases were performed through whole mtDNA sequences to search the mutations and haplogroups, which were associated with the HAPE. The second time, 132 HAPE patients and 127 non-HAPE subjects were collected to apply of verifying these variants and haplogroups of mtDNA with routine PCR method. Results: We analyzed and summarized the clinical characteristics and sequence data for 49 HAPE patients and 58 non-HAPE cases. We found that a series of routine blood indexes including systolic arterial blood pressure (SBP), heart rate (HR), white blood cell (WBC) and C-reactive protein (CRP) in HAPE group presented higher and displayed the significant differences compared with those in non-HAPE group. Though the average numbers of variants in different regions and groups samples were not statistically significant (P > 0.05), the mutation densities of different region in the internal group shown the significant differences. Then we found that two mutations (T16172C and T16519C) associated with the HAPE susceptibility, and the T16172C mutation increased the risk of HAPE, and the T16519C mutation decreased the HAPE rating. Furthermore, the two mutations were demonstrated with 132 HAPE cases and 127 non-HAPE individuals. Unfortunately, all the haplogroups were not associated with the HAPE haplogroups.Conclusions: We provided the evidence of differences in mtDNA polymorphism frequencies between HAPE and non-HAPE Han Chinese. Genotypes of mtDNA 16172C and 16519C were correlated with HAPE susceptibility, which indicated that the role in mitochondrial genome in the pathogenesis of HAPE.
Ethnobotanical Study of Medicinal Plants Used for Human Health Care in Yem Culture, South Ethiopia
Authors: Woldemariam Gideon , Demissew Sebsebe , Asfaw Zemede
Published: March 2021

BackgroundIndigenous or traditional herbal medicine has been widely regarded as a resource for strengthening the health care systems among communities of low income countries including Ethiopia. The Yem people in Ethiopia have deep-rooted and ancient traditional knowledge of managing human ailments and health conditions using medicinal plants (mps). On the other hand, mps and the associated indigenous knowledge are under erosion due to human-induced and natural factors. Therefore, documenting the plant biodiversity along with the associated indigenous knowledge is of urgent task for conservation. MethodsThis study was conducted in April, 2013, October, 2016 and July, 2016 with the objective of documenting traditional mps in different land uses that are used for treating human ailments. Ethnobotanical data were collected from 69 informants that were selected by stratified random sampling and purposive sampling. Vegetation data were obtained from 30, 30x30 m quadrats. Ethnobotanical data were analysed using paired ranking, Informant consensus factor and Fidelity Level index. ResultsAbout 213 medicinal plant species that are used for treating 117 human ailments were recorded. ICF calculated depicted a highest ICF value of 0.82 for Gastrointestinal & Visceral organs ailments. Haplocarpha rueppellii, Carduus schimperi and Inula confortiflora each 100%, Maesa lanceolata 80% and Rumex abyssinicus 75%. Vegetation analysis showed three plant communities.ConclusionThe Yem people have rich traditional knowledge of utilising plants side by side with the mainstream biomedical system for maintaining human health care.
Geotechnical Seismic Vulnerability Assessment of Puerto Vallarta, México
Authors: Escudero Christian R , Gaytan Alejandro Ramirez , Camacho Araceli Zamora , Preciado Adolfo , Flores Karen L. , Hernandez Adan Gomez
Published: March 2021

We performed a seismic vulnerability assessment that involves geotechnical and building structure analysis for Puerto Vallarta, Mexico, a city located along the pacific coast. Like many other Latin American cities, has significant seismic risk. We implemented the multi-channel analysis of surface waves and the horizontal-to-vertical spectral ratio methods to estimate shear wave velocity and soil resonance frequency. We considered standard penetration test to determine the penetration resistance and soil classification. We also defined building typologies based on construction materials and structural systems. The VS30 parameter shows that Puerto Vallarta has the three poorest soil classifications. The resonance frequency parameter shows four zones with different fundamental soil periods. We inferred the building's vulnerability from the coupling between the structural and soil fundamental period and the soil characteristics. The analysis shows several vulnerable buildings scatters within the city, e.g., within the tourist area, confined masonry buildings from one to five stories and moment resistance frame buildings up to 12 in the tourist area, poorly confined masonry houses of one to two stories, and confined masonry buildings of one to five stories in the residential/commercial. We present an approach that combines the academic and government to solve a real and transcendental problem since it might directly affect the regulation and structure evaluations in the area. We are sure that these exercises are of great interest in urban growth areas in other parts of the world, especially in Latin America, to achieve seismic risk mitigation.
Recent Trends in Precipitation Over the Myanmar Coast During Onset and Withdrawal Phases of Monsoon Season
Authors: Yan Xiao , Yao Yibin , Yang Yuanjian , Zhang Liang , Zhang Bao
Published: March 2021

Monsoon precipitation is the major driver of agricultural productivity in the Myanmar Coast, it is crucial to quantify and understand recent changes in precipitation during the monsoon season over this region. By using multiple precipitation datasets, we demonstrate that total precipitation during monsoon season over the Myanmar Coast has increased slightly but not significantly, but precipitation during the onset and withdrawal phases of monsoon season exhibit a significant increasing trend during 1979–2015, and the contribution of precipitation during the two phases to total monsoon precipitation has increased significantly. The increased precipitation during the onset phase over the Myanmar Coast directly results from the earlier onset of the South Asian Summer Monsoon in recent decades, which is associated with the phase transition of the Inter-decadal Pacific Oscillation in the late 1990s. And the precipitation increase during the withdrawal phase is directly due to the enhances of the ascending motion and convection around this region, which is dynamically correlated to the anomalous cyclone-like circulation around the Bay of Bengal as well as the strengthening of the cross-equatorial flow around the equatorial Indian Ocean.
Thermography as a Non-ionizing Quantitative Tool for Diagnosing Endo-perio Lesions
Authors: Aboushady M. Atef , Talaat Wael , Hamdoon Zaid , Elshazly Tarek , Ragy Nivin , Bourauel Christoph , Talaat Sameh
Published: March 2021

Background: Thermography is a contemporary imaging modality based on acquiring and analyzing thermal data using non-contact devices. The aim of the present study was to assess the validity of thermography, compared with that of the gold standard, for the diagnosis of endo-perio lesions and to evaluate the temperature ranges for acute pulpitis with apical periodontitis (AAP), acute periapical abscess (AA) and chronic periapical abscess (CA).Methods: AAP, AA and CA were diagnosed based on clinical and radiographic criteria. Thermographic data were acquired using the FLIR E-5 Infrared Camera. Extraoral thermal images were taken from the front and right and left sides of patients whose mouths were closed, and one intraoral thermal image was taken from the palatal perspective. Agreement in the diagnoses based on the combination of clinical and radiographic assessments and the thermographic evaluation was calculated. The temperature ranges of the three subdiagnostic groups were also measured.Results: A total of 80 patients were enrolled in this study. The mean thermal image temperature for AA was 37.26±0.36, that for CA was 35.03±0.63 and that for AAP was 36.07±0.45. The differences between the mean thermal temperatures of the three diagnostic groups were highly statistically significant (P<0.001). The result of the Kappa coefficient of agreement between the combination of clinical and radiographic assessments and the thermographic evaluation was highly significant (P<0.001). The rates of change in temperature with time for each diagnostic group were highly statistically significantly different (P<0.001).Conclusions: Thermography is an effective, quantitative and nonionizing approach that can be used for the diagnosis of endo-perio lesions. This technology is able to distinguish different forms of infection by identifying the range of temperature increases related to each form.
Effects of combined carbohydrate and protein supplementation on athletic performance and recovery of endurance runners：a double blind, random trial
Authors: Liang Yiheng , Yang Fan , Chen Yan , Geng Guoqiang , Lu Mingyue , Gao Ruirui , Yi Longyan , Qiu Junqiang
Published: March 2021

Background

The aim of this study is to explore the effects of ingesting protein supplementation before endurance exercise.
Methods

10 recreationally active male runners (VO2max: 53.61±3.86 ml/kg•min) completed a run-to-exhaustion test three times. Each test involved 90 minutes of running at 70% VO2max, followed by a time to exhausted test for running at 80% VO2max. All subjects ingested three different, randomly assigned, supplement before the first phase. At the end of the first phase, CHO (carbohydrate) + CHO; PRO (protein) + CHO; CHO + PRO. Both carbohydrate and protein were supplemented at 0.4g•kg− 1BM− 1. Blood samples were obtained before, immediately after and 24 h after exercise for alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK), and myoglobin (MB).
Results

Three different supplement regimens did not cause a significant difference in exhaustion time (CHO + CHO: 432.36 ± 225.51s; PRO + CHO: 463.82 ± 227.45s; CHO + PRO: 461.45 ± 248.5s). However, ALT and AST in PRO + CHO were significantly lower than CHO + CHO 24h after exercise (ALT: 16.8 ± 6.31 VS. 24.39 ± 2.54 U/L; AST: 24.06 ± 4.77 VS. 31.51 ± 7.53 U/L, p < 0.05), and MB in PRO + CHO and CHO + PRO were significantly lower than CHO + CHO 24 h after exercise (40.71 ± 15.16; 38.12 ± 14.32; 64.32 ± 28.86 ng/mL, respectively, p < 0.05). Compared to CHO + CHO, CK in PRO + CHO increased less 24 h after exercise (404.22 ± 75.31 VS. 642.33 ± 68.57 U/L, p < 0.05).
Conclusion

Although combined carbohydrate and protein supplementation did not prolong exhaustion time, it can effectively relieve muscle damage, and it is better to supplement PRO before exercise.
Propranolol and Somatostatin Agonist Therapy Resulting in Symptom Improvement and Stabilization of von Hippel-Lindau-Associated Hemangioblastoma: A Case Report
Authors: Ilanchezhian Maran , Alvarez Reinier , Carbonell Amanda , Widemann Brigitte C. , Chittiboina Prashant , Rivero Jaydira Del
Published: March 2021

Von Hippel-Lindau disease is an inherited, autosomal dominant tumor predisposition syndrome which leads to susceptibility for developing hemangioblastomas of the central nervous system and retina, as well as other tumor types. No approved systemic therapies exist for this disease. Here, we present a patient diagnosed with Von Hippel-Lindau disease, with central nervous system and retinal hemangioblastomas, treated with propranolol and subsequently with Lanreotide. On both treatments, the patient showed notable symptom improvement. In addition, since starting Lanreotide, the patients hemangioblastoma has remained stable on imaging. Based on the symptom improvement in this patient and other reported findings in the literature, propranolol and somatostatin agonist therapy may have an anti-tumor effect in Von Hippel-Lindau associated hemangioblastomas; however, further investigation is warranted.
Green Supplier Selection in New Era for Sustainability: A Novel Method for Integrating Big Data Analytics and a Hybrid Fuzzy Multi-Criteria Decision Making
Authors: YILDIZBASI Abdullah , ARIOZ Yağmur
Published: March 2021

Environmentally conscious supplier selection has become increasingly important in recent years. Green supplier selection is one of the vital decisions of supply chain management, as it is preferred for businesses in the market that adopt an environmental approach and green philosophy in line with material and moral benefits. In this context, the problem of choosing the most efficient green supplier is addressed with a three-step methodology using big data analysis that includes an integrated approach and hybrid fuzzy AHP-TOPSIS techniques. First of all, big data plays an important role in delivering meaningful results by reducing complexity to a more fundamental level. It is possible to obtain more consistent results by examining a series of criteria in green supplier selection at a more reasonable and operational level. Thus, the role of big data analysis provides an input for decision-making, which enables a systematic reduction to more concise data. Then, these inputs are evaluated in a fuzzy environment with hybrid MCDM techniques and the most efficient green supplier is determined among the suppliers. This authentic study sheds light on providing a significant competitive advantage to businesses in line with their strategic targets as well as having environmental contributions to sustainability.
Flexible ZnO photoelectrode for photo electrochemical energy conversion
Authors: Shiyani T. , Banerjee Indrani , Mahapatra Santosh K. , Ray Asim K
Published: March 2021

Photoelectrochemical properties have been investigated for flexible ZnO/ITO/PET photoelectrodes. ZnO was spin coated on ITO/PET substrate with thickness of about 310 nm. The high crystalline structure of ZnO was studied using x-ray diffraction pattern. A value of 3.4 eV has been estimated for optical band gap from its absorption spectra. The flexible ZnO photoelectrode was demonstrated to generate photoelectrochemical current. Values of 1.022 and 0.714 were found to be for photo switching and photoresponsivity, respectively. ZnO/ITO/PET can be used as a substrate for making flexible hybrid PEC devices to generate solar power and solar fuels.
Kinetics of HE4 and CA125 as prognosis biomarkers during neoadjuvant chemotherapy in advanced epithelial ovarian cancer
Authors: Alegría-Baños Jorge A. , Jiménez-López José C. , Vergara-Castañeda Arely , de León David F. Cantú , Mohar-Betancourt Alejandro , Pérez-Montiel Delia , Sánchez-Domínguez Gisela , García-Villarejo Mariana , Olivares-Pérez César , Hernández-Constantino Ángel , González-Santiago Acitlalin , Clara-Altamirano Miguel A. , Arela-Quispe Liz , Prada-Ortega Diddier G.
Published: March 2021

Background
Ovarian cancer (OC) is considered the most lethal gynecological cancer, of which more than 65% cases are diagnosed in advanced stages, requiring platinum-based neoadjuvant chemotherapy (NACT).
Methods
A prospective-longitudinal study was conducted among women with advanced epithelial ovarian cancer (AEOC), III and IV stages, and treated with NACT, at the National Cancer Institute – Mexico, from July 2017 to July 2018. Serum samples were obtained for quantification of CA125 and HE4 using ELISA at the first and in each of the three NACT cycles. The therapeutic response was evaluated through standard tomography. We determined whether CA125 and HE4, alone or in combination, were associated with TR to NACT during follow up.
Results
53 patients aged 38 to 79 years were included, 92.4% presented papillary serous subtype OC. Higher serum HE4 levels were observed in patients with non-tomographic response (6.89 vs 5.19 pmol/mL; p = 0.031), specially during the second (p = 0.039) and third cycle of NACT (p = 0.031). Multivariate-adjusted models showed an association between HE4 levels and TR, from the second treatment cycle (p = 0.042) to the third cycle (p = 0.033). Changes from baseline HE4 levels during the first cycle was negative associated with TR. No associations were found between CA125 and TR.
Conclusions
Serum HE4 levels were independently associated with TR among patients with AOEC treated with NACT, also a reduction between baseline HE4 and first chemotherapy levels was also independently associated with the TR. These findings might be relevant for predicting a lack of response to treatment.
GP-DMD: A Genetic Programming variant with Dynamic Management of Diversity
Authors: Fuentes Ricardo Nieto , Segura Carlos
Published: March 2021

The proper management of diversity is essential to the success of Evolutionary Algorithms. Specifically, methods that explicitly relate the amount of diversity maintained in the population to the stopping criterion and elapsed period of execution, with the aim of attaining a gradual shift from exploration to exploitation, have been particularly successful. However, in the area of Genetic Programming (GP), the performance of this design principle has not been studied. In this paper, a novel GP variant, Genetic Programming with Dynamic Management of Diversity (GP-DMD), is presented. GP-DMD applies this novel design principle through a replacement strategy that combines penalties based on distance-like functions with a multi-objective Pareto selection based on maximizing accuracy and minimizing tree size. The experimental validation based on the symbolic regression task considers several state-of-the-art approaches and shows clear improvements both in terms of accuracy and simplicity. The effects of GP-DMD on the dynamics of the population are also analyzed, revealing the reasons for the superiority of GP-DMD. As in other fields of Evolutionary Computation, this design principle contributes significantly to the area of GP.
Reduced False Positives in Autism Screening Via Digital Bio-markers Inferred from Deep Co-morbidity Patterns
Authors: Chattopadhyay Ishanu , Onishchenko Dmytro , Huang Yi , Smith Peter J. , Msall Michael M. , Horne James van
Published: March 2021

Autism spectrum disorder (ASD) is a developmental disability associated with significant social and behavioral challenges. There is a need for tools that help identify children with ASD as early as possible. Our current incomplete understanding of ASD pathogenesis, and the lack of reliable biomarkers hampers early detection, intervention, and developmental trajectories. In this study we develop and validate machine inferred digital biomarkers for autism using individual diagnostic codes already recorded during medical encounters. Our risk estimator identifies children at high risk with a corresponding area under the receiver operating characteristic curve (AUC) exceeding 80% from shortly after two years of age for either sex, and across two independent databases of patient records. Thus, we systematically leverage ASD co-morbidities - with no requirement of additional blood work, tests or procedures - to compute the Autism Co-morbid Risk Score (ACoR) which predicts elevated risk during the earliest childhood years, when interventions are the most effective. By itself, ACoR has superior performance to common questionnaires-based screenings such as the M-CHAT/F, and has the potential to reduce socio-economic, ethnic and demographic biases. In addition to superior standalone performance, independence from questionnaire based screening allows us to further boost performance by conditioning on the individual M-CHAT/F scores - we can either halve the false positive rate of current screening protocols or boost sensitivity to over 60%, while maintaining specificity above 95%. Adopted in practice, ACoR could significantly reduce the median diagnostic age for ASD, and reduce long post-screen wait-times experienced by families for confirmatory diagnoses and access to evidence based interventions.
Organisational Implementation Climate in implementing internet-based Cognitive Behaviour Therapy for depression
Authors: Vis Christiaan , Kleiboer Annet , Mol Mayke , Pedersen Claus Duedal , Finch Tracy , Smit Jan , Riper Heleen
Published: March 2021

Background. Internet-based Cognitive Behaviour Therapy (iCBT) services for depression have been implemented in routine care in 14 European regions. This study aimed to advance understanding of the nature and value of organisational implementation climate in implementing iCBT services from the perspectives of implementers and service deliverers.Methods. A mixed method approach was applied. Based on concept mapping, a workshop with implementers was conducted to qualitatively conceptualise organisational implementation climate conducive to optimizing iCBT use in routine practice. Mental health service deliverers involved in the provision of iCBT services were invited to participate in a cross-sectional survey assessing levels of satisfaction and usability of iCBT, and of the organisational implementation climate. Associations between satisfaction, usability and implementation climate were explored.Results. 16 implementers representing 14 service delivery organisations participated in the workshop. The top-3 characteristics of a strong organisational implementation climate included: (1) clear roles and skills of implementers, (2) feasible implementation targets, and (3) a dedicated implementation team. The top-3 tools for creating a good implementation climate included: (1) job performance feedback, (2) progress monitoring in achieving implementation targets, and (3) guidelines for assessing the impact of iCBT. 111 respondents (73% female) completed the survey. Respondents were generally satisfied delivering iCBT services (MCSQ = 9.11, SD = 1.96, range = 3-15, n = 108) and found their usability slightly below average (MSUS = 63.76, SD = 15.53, range = 0-100, n = 103). They regarded their organisational implementation climate as supportive in implementing iCBT services (MICS = 43.21, SD = 5.62, range = 12-60, n = 89). Organisational implementation climate was weakly associated with usability (r = 0.25, p =.03) and moderately with satisfaction (r = .51, p £ .00).Conclusions. Organisational implementation climate as part of the wider organisational context in which implementation processes take place, is a relevant factor to implementers and service deliverers in implementing iCBT in routine care. The qualitative conceptual findings align with the quantitative approach applied in this study for measuring organisational implementation climate. Implementers can use various practical tools to shape organisational implementation climate to increase acceptance and improve implementation of iCBT in mental health care.
­ Apatinib combined with PD-L1 blockade synergistically enhances antitumor immune responses and promotes HEV formation in gastric cancer
Authors: Zhang Yu , Wang Fei , Sun Hao-ran , Huang Ya-kai , Gao Jian-peng , Huang Hua
Published: March 2021

Purpose
Apatinib, an antiangiogenic drug, has showed beneficial effects only in a fraction of advanced gastric cancer (GC) patients. Given the recent success of immunotherapies, combination of apatinib with immune checkpoint inhibitor may provide sustained and potent antitumor responses.
Methods
Immunocompetent mice with subcutaneous MFC tumors grown were given combination of apatinib and anti-PD-L1 antibody therapy. GC tissues from patients undergoing curative resection in China were collected, and the density of HEVs, MSI status and tumor-infiltrated lymphocytes were analyzed by immunohistochemical staining.
Results
Combined apatinib and PD-L1 blockade therapy synergistically delayed tumor growth and increased survival in MFC-bearing immunocompetent mice. The combination therapy promoted antitumor immunity by increasing the ratio of CD8+ cytotoxic T cells to Foxp3+ Treg cells, the accumulation of CD20+ B cells and the Th1/Th2 cytokine ratio (IFN-γ/IL-10). The combination therapy induced the formation of HEVs through activation of LTβR signaling, thus promoting CD8+ cytotoxic T cell and CD20+ B cell infiltration in tumors. In clinical GC samples, the density of HEVs positively correlated with the intratumoral infiltration of CD8+ cytotoxic T cells and CD20+ B cells. MSI-high GC showed a higher density of HEVs, CD8+ cytotoxic T cells and CD20+ B cells than MSS/MSI-low GC. GC patients with high densities of HEVs, CD8+ cytotoxic T cells and CD20+ B cells had an improved prognosis with superior overall survival.
Conclusion
Combining apatinib with PD-L1 blockade treatment synergistically enhances antitumor immune responses and promotes HEV formation in GC.
TGF-β and CCL18 as indicators for predicting and monitoring the development of pulmonary fibrosis in patients with COVID-19
Authors: Zong Ming , Zheng Liang , Zhou Huan , Lu Liu , He Long , Wu Xiaodong , Chen Nianzhen , Wang Lan , Yuan Jiayi , Jiang Erpeng , Shi Yan , Li Qiang , Fan Lieying , Liu Zhongmin
Published: March 2021

Background

Many COVID-19 patients have been discharged, but lung injury, including pulmonary fibrosis, might lead to long-term impairment. This study aimed to evaluate predictors and monitors of pulmonary fibrosis in patients with COVID-19.
Methods

Thirty-five convalescent patients with severe COVID-19, after appropriate medical treatments, were recruited. According to evidence of fibrosis on initial computed tomography (CT), the patients were divided into mild-to-moderate and severe groups. Levels of transforming growth factor beta (TGF-β), chemokine ligand 18 (CCL18), type III procollagen peptide (PⅢP), hyaluronic acid (HA), laminin (LN), and type IV collagen (CⅣ) were determined. Laboratory tests, clinical data, and CT features at different stages were collected and analyzed, and the prognostic performance of these parameters was evaluated.
Results

Severe fibrosis was found in 76.29% (26/35) of patients. However, most baseline laboratory characteristics were normal. Fibrosis indicators (TGF-β: 66.67 ± 158.57 vs 55.84 ± 126.43 pg/mL, P = 0.006; CCL18: 364.27 ± 167.70 vs 84.47 ± 60.67 ng/mL, P = 0.000; PⅢP: 54.12 ± 55.34 vs 17.15 ± 2.48 ng/mL, P = 0.000; HA: 122.47 ± 78.84 vs 59.74 ± 18.01 ng/mL, p = 0.000; LN: 55.43 ± 46.44 vs 24.25 ± 7.79 ng/mL, P = 0.000; CⅣ: 24.77 ± 14.97 vs 15.32 ± 1.15 ng/mL, P = 0.001) were elevated in patients compared with controls. Over 90 days’ follow-up, HRCT scores gradually decreased from 22.48 ± 16.13 to 10.33 ± 11.11 (P < 0.001), and mMRC scores decreased from 3.27 ± 0.32 to 1.48 ± 0.33, and all fibrosis indicators, except for PⅢP, gradually declined with the improvement of pulmonary fibrosis. Moreover, TGF-β and CCL18 levels were lower in the mild-to-moderate than severe fibrosis group (88.16 ± 97.45 vs 205.93 ± 170.57 pg/mL, P = 0.024; 241.84 ± 125.37 vs 366.64 ± 161.06 ng/mL, P = 0.038), and patients with elevated baseline levels of serum TGF-β and CCL18 had longer rehabilitation times.
Conclusions

TGF-β and CCL18 may be promising biomarkers for predicting and monitoring the development of pulmonary fibrosis in patients with COVID-19.
Lesão por armlock em atleta amador de jiu-jitsu: relato de caso
Authors: Alves Rezende Luis Guilherme Rosifini , Shimaoka Filipe Jun , Shimabukuro Gunter Shin Iti Takamori , Mandarano-Filho Luiz Garcia , Mazzer Nilton , Barbieri Cláudio Henrique
Published: March 2021

O jiu-jitsu brasileiro é uma modalidade de arte marcial que utiliza o princípio da imobilização para a execução de seus golpes. Este esporte tem apresentado aumento do número de praticantes nas últimas duas décadas. Isto implica no aumento do número de lesões, principalmente quando se considera o perfil dos atletas amadores. As lesões do cotovelo no jiu-jitsu estão entre as lesões mais comuns nesta modalidade esportiva.  O mecanismo de trauma mais observado é a hiperextensão forçada durante a aplicação da chave de braço (armlock ou armbar). Apresentamos um relato de caso de um paciente de 26 anos com uma lesão aguda do complexo ligamentar medial por chave de braço durante uma luta de jiu-jitsu. O paciente foi submetido ao tratamento conservador, com imobilização e fortalecimento da musculatura flexo-pronadora. Realizou-se o retorno gradual ao esporte, apresentando bom resultado funcional do cotovelo e do membro superior após quatro anos de seguimento.
Punica granatum, lippia sidoides, mikania glomerata e mikania laevegata: ação sobre o biofilme dental
Authors: Queiroz Rauhan Gomes de , Oliveira Sandson Cleyton Ferreira da Silva , Fragoso Lukas Natã Mendes , Flores Nathalia da Cruz , Freitas Ana Letícia Alcântara , Sousa Millena Lorrana de Almeida , Santos Maria Vitória Calado Ramalho dos , Jesus Felipe Franklin de , Lacerda José Wanderson , Linhares Layara Maria Vieira , Oliveira Filho Abrahão Alves de
Published: March 2021

As plantas medicinais vêm sendo mais utilizadas devidos às suas propriedades preventivas, paliativas e curativas, além de ser uma terapia diferente, trazendo inúmeros benefícios aos usuários. A Punica granatum Linn pertence a família Lythracaceae, sendo popularmente conhecida como “Romã”. Em forma de colutório a romã pode demonstrar eficácia sobre diversos microorganismos formadores do biofilme dental, além de ajudar na redução do sangramento gengival. A Lippia sidoides Cham pertence à família Verbenaceae, popularmente conhecida como “Alecrim-pimenta”. Seu uso tem mostrado uma alta atividade antimicrobiana contra fungos e bactérias, incluindo espécies do gênero Streptococcus mutans, como, também, a redução da gengivite e placa bacteriana. As Mikania glomerata e a Mikania laevegata, pertencem a mesma família Asteraceae e são popularmente conhecidas como “Guaco” e possuem atividade antimicrobiana sobre o Streptococcus mutans. O presente trabalho teve como objetivo realizar uma revisão bibliográfica sobre o uso de fitoterápicos na Odontologia, em especial quanto à atividade microbiana das plantas Punica, Lippia e Mikania, as propriedades farmacológicas dessas e sua atuação sobre o biofilme dental. Trata-se de uma revisão literária do tipo narrativa, onde foi realizada uma seleção de trabalhos científicos já elaborados sobre os aspectos das propriedades farmacológicas da Mikania glomerata, Mikana laevigata, Punica granatum Linn. e da Lippia sidoides Cham, através das bases de dados: LILACS, SciELO, MEDLINE, BVS, além de monografias, teses, dissertações e livros. Foi visto na literatura que todas as plantas pesquisadas possuem efeito sobre o biofilme dental quando em baixa concentração e de acordo com suas propriedades químicas e fitoterápicas.
Characterization of carbon phases in Yamato 74123 ureilite to constrain the meteorite shock history
Authors: Barbaro Anna , Nestola Fabrizio , Pittarello Lidia , Ferrière Ludovic , Murri Mara , Litasov Konstantin D. , Christ Oliver , Alvaro Matteo , Domeneghetti M. Chiara
Published: March 2021

The formation and shock history of ureilite meteorites, a relatively abundant type of primitive achondrites, has been debated for decades. For this purpose, the characterization of carbon phases can provide further information on diamond and graphite formation in ureilites, shedding light on the origin and history of this meteorite group. In this work, we present X-ray diffraction and micro-Raman spectroscopy analyses performed on diamond and graphite occurring in the ureilite Yamato 74123 (Y-74123). The results show that nano- and microdiamonds coexist with nanographite aggregates. This, together with the shock-deformation features observed in olivine, such as mosaicism and planar fractures, suggest that diamond grains formed by a shock event (≥15 GPa) on the ureilitic parent body (UPB). Our results on Y-74123 are consistent with those obtained on the NWA 7983 ureilite and further support the hypothesis that the simultaneous formation of nano- and microdiamonds with the assistance of a Fe-Ni melt catalysis may be related to the heterogeneous propagation and local scattering of the shock wave. Graphite geothermometry revealed an average recorded temperature (Tmax) of 1314 °C (±120 °C) in agreement with previously estimated crystallization temperatures reported for graphite in Almahata Sitta ureilite.
Entanglement Dynamics of Random GUE Hamiltonians
Authors: Chernowitz Daniel , Gritsev Vladimir
Published: March 2021

In this work, we consider a model of a subsystem interacting with a reservoir and study dynamics of entanglement assuming that the overall time-evolution is governed by non-integrable Hamiltonians. We also compare to an ensemble of Integrable Hamiltonians. To do this, we make use of unitary invariant ensembles of random matrices with either Wigner-Dyson or Poissonian distributions of energy. Using the theory of Weingarten functions, we derive universal average time evolution of the reduced density matrix and the purity and compare these results with several physical Hamiltonians: randomized versions of the transverse field Ising and XXZ models, Spin Glass and, Central Spin and SYK model. The theory excels at describing the latter two. Along the way, we find general expressions for exponential n-point correlation functions in the gas of GUE eigenvalues.
Consecuencias y conductas clínicas frente a accidentes por extravasación de NaClO en endodoncias
Authors: Vaz de Freitas Sirlei , Tomazinho Luiz Fernando , Holanda de Medeiros Batista Mara Ilka , Tavares Carvalho Alessandra Albuquerque , Ribeiro Paulino Marcília
Published: March 2021

La terapia endodóntica prevé la descontaminación químico-mecánica de los canales radiculares, siendo el hipoclorito de sodio (NaClO) la sustancia química más utilizada. Se buscó realizar una revisión crítica de la literatura sobre las consecuencias de accidentes por extravasación de NaClO durante el tratamiento endodóntico y las conductas clínicas necesarias en esos casos. Las búsquedas de bases de datos fueron realizadas en Scielo y Lilacs con descriptores em portugués, y la base de datos PubMed con descriptores en Inglés, obteniéndose 98 registros de artículos disponibles para la lectura completa, publicados desde 2003 hasta 2018. Se incluyeron aquellos cuya temática respondía a los cuestionamientos en discusión: HClO como irrigante endodóntico; factores que afectan la extrusión del hipoclorito en tratamientos endodónticos, consecuencias y manejo clínico en caso de extravasación del riego. La extrusión del hipoclorito más allá del agujero apical conduce a la destrucción del tejido y la necrosis. Sin embargo, son pocos los estudios con recomendaciones después de accidentes por extravasación de NaClO en la clínica endodôntica. En casos de accidentes, se debe aspirar la sustancia y lavar el área con solución salina estéril. No existe un protocolo único para la intervención, se debe evaluar el alcance y la gravedad del accidente. La prioridad es el alivio del dolor, el control del edema y la prevención de infecciones secundarias. El profesional debe atentar a la posibilidad diaria de accidentes y adoptar medidas preventivas.
The Relationship between Culture and Social Capital with the Sustainability of Microfinance
Authors: Firdaus Nur
Published: March 2021

Poverty has been the biggest problem around the world, and one of the innovative solutions offered is microfinance. Since the success story of Grameen Bank has been widely spread, many countries decided to adopt microfinance programs to alleviate poverty. Microfinance is then believed as an effective instrument that can answer the poverty challenges. Several studies have analysed the impact of microfinance on poverty reduction, but the results varied. Some support that microfinance can improve the poor, but other criticise and argue that microfinance does not play a significant role to reduce the poverty rate and even undermine the poor. This article aims to analyse factors, namely culture and social capital, that can influence the sustainability of microfinance performance. The assumption used in this article is that the success of microfinance cannot be separated from the borrowers’ background that influences their behaviours towards microfinance. The article summarised a number of studies that have discussed this issue using a qualitative approach. The findings show that culture and social capital have an impact on the sustainability of microfinance, but the impacts depend on the condition of cultures and social capital in a society. However, additional supports are needed and should not be ignored to accelerate the impact of microfinance.
Role of Insurance Sector on Inclusive Growth in India
Authors: Jana Debabrata
Published: March 2021

In the present era insurance sector plays a vital role in both developed and developing countries. Insurance markets working as a financial intermediary to contribute economic growth of the country as well as risk management more efficiently. The purpose of the study is to investigate the relationship between insurance sector development and economic growth in India. For this study, data has been collected only from the secondary sources for the period 2000 to 2019. To run linear regression, four variables are taken viz. GDP as a surrogate of economic growth and Real Premium Growth Rate, Total Investment in Insurance Sector and Insurance Claim. Finally, it can be suggested that more attention in the insurance market is to be paid so that proper economic growth will be possible in the developing country in India.
Dampak Faktor Makroekonomi terhadap Non Performing Loan pada Kredit Produktif Bank Umum di Indonesia
Authors:   Sekolah Bisnis dan Ekonomi -Universitas Prasetiya Mulya BSD City Kavling Edutown I.1 , Jl. BSD Raya Utama, BSD City, Tangerang 15339, Hernando Alben , Miranda Elvaretta ,   Sekolah Bisnis dan Ekonomi -Universitas Prasetiya Mulya BSD City Kavling Edutown I.1 , Jl. BSD Raya Utama, BSD City, Tangerang 15339, Theodora Lauw Luvena Aileen ,   Sekolah Bisnis dan Ekonomi -Universitas Prasetiya Mulya BSD City Kavling Edutown I.1 , Jl. BSD Raya Utama, BSD City, Tangerang 15339, Kadarusma Yohanes B. ,   Sekolah Bisnis dan Ekonomi -Universitas Prasetiya Mulya BSD City Kavling Edutown I.1 , Jl. BSD Raya Utama, BSD City, Tangerang 15339, Ariyan Glisera Agri ,   Sekolah Bisnis dan Ekonomi -Universitas Prasetiya Mulya BSD City Kavling Edutown I.1 , Jl. BSD Raya Utama, BSD City, Tangerang 15339
Published: March 2021

This study aims to find out the factors that affect non-performing loans of productive loans of commercial banks registeredin oritas Jasa Keuangan. This study examined the macroeconomic variables that affect productive credit NPLs. The sample used is a commercial bank in Indonesia, which is registered in OJK. Productive credit NPL data are taken quarterly from 2003 to 2017,and 56 observationsare obtained. The regression model used in this study is ARDL, with the help of processing Eviews 10 software. The macroeconomic variables tested in this research consist of GDP growth, loan interest rates growth, and IDR/ USD exchangerate growth. GDP growth and exchange rate growth has a negative relationship, while loan interest rates growth does not have a significant relationship with the dependent variable.
Dampak Pencatatandan Jatuh TempoWaran terhadap Harga Saham yang Disertai Waran di Indonesia
Authors:   Sekolah Bisnis dan Ekonomi -Universitas Prasetiya Mulya BSD City Kavling Edutown I.1 , Jl. BSD Raya Utama, BSD City, Tangerang 15339, Suryawinata Stefan , Tekadtuera Aldwin ,   Sekolah Bisnis dan Ekonomi -Universitas Prasetiya Mulya BSD City Kavling Edutown I.1 , Jl. BSD Raya Utama, BSD City, Tangerang 15339, Ervina Dahlia ,   Sekolah Bisnis dan Ekonomi -Universitas Prasetiya Mulya BSD City Kavling Edutown I.1 , Jl. BSD Raya Utama, BSD City, Tangerang 15339
Published: March 2021

This research discusses the stock abnormal return effect of warrants to its underlying stock on its listing and maturity date. This study sample is the stock price changes of stocks backed with a warrant in the Indonesian stock market for the year 2008 to 2018—using an event study approach to observe stock abnormal return effect on the listing and maturity date of warrants. The results of this research are that we find a significant negative abnormal return around the warrants' listing date. On the warrants' expiration date, we find a significant negative effect before and after the money warrants' maturity date. However, a different result is obtained for the observation of out-of-the-money warrants that do not show any significant abnormal return on the event window.
Potential Therapeutic Relevance of CRISPR/Cas9 Guided Epigenetic Regulations for Neuropsychiatric Disorders
Authors: Singh Desh D. , Verma Ravi , Parimoo Piyush , Sahu Ashish , Kumar Vikram , Upadhyay Era , Yadav Dharmendra K.
Published: March 2021

Brain function activity is regulated by several mechanisms of genetic and epigenetic factors
such as histone modelling, DNA methylation, and non-coding RNA. Alterations in these regulatory
mechanisms affect the normal development of neurons that causes Neuropsychiatric Disorders
(ND). However, it is required to analyse the functional significance of neuropsychiatric disorders
associated with a molecular mechanism to bring about therapeutic advances in early diagnosis
and treatment of the patients. The CRISPR/Cas 9 (Clustered Regularly Interspaced Short Palindromic
Repeats) genome editing tools have revolutionized multiple genome and epigenome manipulation
targets the same time. This review discussed the possibilities of using CRISPR/Cas 9 tools
during molecular mechanism in the ND as a therapeutic approach to overcome ND that is caused
due to genetic and epigenetic abnormalities.
EKSPLORASI DAN UJI ANTAGONISME JAMUR FILOPLANE TERHADAP JAMUR Fusarium sp. PENYEBAB PENYAKIT BUSUK KERING PADA DAUN SRI REJEKI (Aglaonema sp.)
Authors: Ismahmudi Asri , Sastrahidayat Ika Rochdjatun , Djauhari Syamsuddin
Published: March 2021

Penelitian ini bertujuan untuk mengetahui jamur filoplane pada daun Aglaonema dan mengidentifikasi antagonisme penyakit busuk kering pada daun Aglaonema yang disebabkan oleh Fusarium sp. Penelitian yang dilakukan meliputi identifikasi jamur patogen, eksplorasi jamur filoplane, dan uji antagonisme. Penelitian ini dilaksanakan di Sub Laboratorium Mikologi Jurusan Hama dan Penyakit Tumbuhan Fakultas Pertanian Universitas Brawijaya Malang. Uji antagonisme dilakukan dengan menggunakan Rancangan Acak Lengkap yang terdiri dari 12 perlakuan dan empat ulangan. Hasil penelitian menunjukkan ada tujuh jenis jamur filoplane yaitu genus Acromonium, Trichoderma, Cephalosporium, Mucor, Rhizopus, Fusarium, dan Aspergillus. Dari tujuh jenis jamur filoplane yang ditemukan, Trichoderma sp. memiliki daya hambat tertinggi (71,5%) terhadap pertumbuhan patogen Fusarium sp. Aplikasi suspensi dengan kerapatan 106 konidia/ml air Trichoderma sp. pada daun Aglaonema terbukti dapat menghambat penyakit busuk kering.
Predictors associated with and the prevalence of condylomata acuminata infection among people in Southern Brazil
Authors: Peder Leyde Daiane de , Silva Claudinei Mesquita da , Madeira Heloise Skiavine , Malizan Josi Any , Nascimento Bruna Larissa , Horvath Josana Dranka , Silva Eraldo Schunk , Teixeira Jorge Juarez Vieira
Published: March 2021

Objectives:  To estimate the prevalence of condylomata acuminata/HPV and evaluate associated predictors in infected patients. Methods: In this cross-sectional and retrospective study, medical records of patients who attended a public health referral center located in Southern Brazil, Parana, between April 2012 and March 2017 were reviewed. Epidemiological, clinical, and laboratory data were analyzed using the chi-square and odds ratio (OR) with 95% confidence interval (CI). Results: The overall prevalence of condylomata acuminata/HPV in 3,447 patients was 33.1% (n = 1,140). Coinfection of condylomata/HPV with other STI was noted in 23.7% (n = 270) of cases. The population was characterized by a high prevalence (43.8%) in patients aged < 20 years, women (37.4%), white (33.3%), educational level with more than 8 years of study (33.7%), widowed (39.2%), heterosexual (36.7%), and ages between 13 and 19 years at first sexual intercourse (41.1%). A significant association was observed between male sex and multiple partners and between male sex and irregular use of condoms (p < 0.001). The predictors associated with HPV infection were the age group of up to 29 years (OR 2.0, 95% CI 1.3–3.7, p < 0.013) and homosexual/bisexual (OR 0.2, 95% CI 0.12–0.66, p = 0.003). Conclusion: The findings showed a high prevalence of condylomata acuminata in a public health center study, with emphasis on the age range below the third decade of life and sexual behavior predictors. These predictors are important for the determination of preventive measures against the transmission of infection and the development of cancer.