bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Faktor Fundamental Mikro Makro terhadap Harga Saham Sektor Perbankan
Authors: Rezeki Yuliarti , Wulandari Dyah Sri , Kusumawati Linda
Published: July 2022

Micro and macroeconomic fundamentals can affect the company's stock price. This is the background of this research. The objective is to analyze the microeconomic fundamentals, which consist of ROA, EPS, DER and macroeconomic fundamentals, namely inflation, Exchange and BI Rate against stock prices. The analytical method used is multiple linear regression with a population of 13 companies listed on the Stock Exchange and have met the sample criteria. Data in the form of banking financial reports for 2015-2019 and other data were obtained from Bank Indonesia, the Central Bureau of Statistics, and the Indonesian Stock Exchange. The results of the f test conclude that the micro and macroeconomic variables have a significant effect. The results of the t-test are only the ROA, DER and BI-Rate variables which are significant while the EPS, inflation, and exchange rate variables are not significant. The conclusion of this research for investors can consider ROA and DER variables as a measure of company performance. The BI Rate variable can be taken into consideration in determining investment strategies. An increase or decrease in interest rates greatly affects the economic condition of a country. For companies, analysis of microeconomic and macroeconomic factors is important in determining policy.
Pengaruh Pemasaran Digital dan Kesadaran Merek terhadap Keputusan Pembelian di Store Zoya
Authors: Erpurini Wala , Rukmana Maman , Fajrin Syifa Aulia
Published: July 2022

This study aims to determine the effect of digital marketing and brand awareness on purchasing decisions at Zoya Bandung Indah Plaza. The population of this study includes members who buy products at Zoya Bandung Indah Plaza. The survey subjects in this study amounted to 100 people. This research method uses descriptive and linked research methods. This method considers the influence between the independent variable and the dependent variable. The results of the descriptive analysis research show that digital marketing and brand awareness on purchasing decisions at Zoya Bandung Indah Plaza are very good. The data analysis technique used is link test path analysis. It shows that the influence of digital marketing on purchasing decisions is 2%, the influence of brand awareness on purchasing decisions is 387 % of the influence of brand awareness and digital marketing on purchasing decisions at Zoya Bandung Indah Plaza is 829%.
Pengaruh Penerapan Sistem Pengendalian Manajemen (SPM), Motivasi Dan Gaya Kepemimpinan Terhadap Kinerja Manajerial PT. Bank Pembangunan Daerah Jambi
Authors: Hastuti Wulan Novi , Herawaty Netty , Lutfi Lutfi
Published: July 2022

This study aims to determine and analyze whether the application of management control systems, motivation and leadership style affect managerial performance at PT. Bank Pembangunan Daerah Jambi either simultaneously or partially. The implementation of management control system, motivation and leadership style are independent variables, while managerial performance is the dependent variable. This type of research is quantitative where the type of data used is primary data in the form of a questionnaire at PT. Bank Pembangunan Daerah Jambi. The data analysis technique used in this research is multiple linear regression analysis. The population in this study is all levels of organizational management at PT. Bank Pembangunan Daerah Jambi with a total sample of 52 people. The results of this study indicate that management control system, motivation and leadership style affect managerial performance at PT. Bank Pembangunan Daerah Jambi.
Electronic Word of Mouth (eWOM): Menguji Pengaruh Pengalaman Positif, Persepsi Kualitas dan Kepercayaan. Studi Kasus: Restoran di Labuhanbatu
Authors: Prayoga Yudi , Pohan Muhammad Yasir Arafat
Published: July 2022

Compared to traditional methods, the Internet as a means of communication offers several advantages such as constant availability of information, efficient transfer of information and interactivity. In the context of the culinary business, the contribution of customers who want to spread positive information about restaurants is certainly very large. According to the literature, it was also conveyed that consumers believed in previous consumer experiences more than the advertisements delivered by the company. This study wants to examine the role of positive experience variables, perceived quality and trust in the eWOM behavior of restaurant customers in Labuhanbatu. The study used a quantitative approach using a questionnaire as a data collection tool. Questionnaires were distributed via google form to respondents. Respondents in this study were restaurant customers in Labuhanbatu who had carried out eWOM activities to the people around them. This study uses the SEM analysis method with the help of SMART PLS 3 software. The results of this study indicate that all predictive variables analyzed have a positive and significant influence on positive eWOM behavior in the context of a restaurant in Labuhanbatu.
Model Peningkatan Kinerja Melalui Disiplin Kerja Sebagai Intervening pada Pegawai Dinas Pendidikan Kota Padang
Authors: Eliza Yulina , Andria Yass , Adriani Evi
Published: July 2022

Performance is a picture of the results achieved in the implementation of a policy realized through the strategic planning of an organization including the goals, goals, vision, and mission of the organization. The performance of employees of the Regional Device Organization (KOPD) of the Padang City Education Office is still not optimal, where the placement of employees is not by the competencies needed by the organization. Employee absenteeism increased by 2-5% per month due to several things such as delays in employees entering the office, employees applying for permission for family affairs and employees who do not give news or without information. The purpose of this study was to test variables that affect employee performance using work discipline intervening variables with 101 samples at the Padang City Education Office. The results of the study prove that: 1) employee discipline is positively and significantly influenced by work competence; 2) employee discipline is positively and significantly influenced by work culture; 3) employee performance is positively and significantly affected by work competence; 4) employee performance is positively and significantly affected by the work culture; 5) Employee performance is positively and significantly affected by work discipline; 6) Employee performance is positively and significantly affected by work competence with work discipline as an intervening variable; 7) Employee performance is positively and significantly influenced by work culture with work disciplines such as intervening variables in the Padang City Education Office.
Pengaruh Pendapatan Asli Daerah, Dana Alokasi Umum, dan Dana Bagi Hasil terhadap Belanja Modal pada Daerah Pemekaran di Provinsi Jambi
Authors: Syukri Muhammad , Alhudhori M , Adisetiawan R
Published: July 2022

Local taxes are the obligation of citizens to finance various regional needs to carry out regional development. This is an important benchmark for contributing to increasing local revenue in implementing regional autonomy. This study aims to determine how much the contribution of provincial taxes in increasing local revenue (PAD) in Jambi province.Based on the result of the analysis contribution and Analysis Process Hierarchy (AHP), get the results of the research in the form that of the five (5) province taxes that greatly contribute to increasing local revenue, namely Motor Vehicle Tax, Motor Vehicle Transfer Fee Tax and Motor Vehicle Fuel Tax. These three taxes greatly contribute, which for motor vehicle taxes in 2017-2019 or the last 3 years can contribute 27.91%, motor vehicle transfer fees tax contributes 22.67% and motor vehicle fuel taxes contribute 19.39 % . Meanwhile, the other two taxes, the surface water tax and the cigarette tax, began to contribute to local revenue (PAD), although their contribution was not very large.
Analisis Pengaruh PMDN dan PMA terhadap Perekonomian Provinsi Jambi
Authors: Fahmi Ali , Adriani Evi
Published: July 2022

Economic development carried out by a State aims to realize a prosperous, just and prosperous society. The success of a development can be seen from the development of existing economic indicators, whether it has increased or decreased. Gross Regional Domestic Product (PDRB) is included in one of the indicators of development of a region to see the level of community welfare in a region. PDRB which tends to increase indicates an increase in development and community welfare that continues to improve, while the Declining GDP reflects the decline in development and a decrease in the level of community welfare. Investment is an important factor in determining the level of national income which means it depends on the amount of capital and technology planted and developed in society. Investment activities allow an area to continuously increase economic activity and employment opportunities. This increase in investment in both government and private is very important. The conceptual framework in this study is that the Economy of Jambi Province is influenced by two economic variables, namely; PMDN investment and PMA investment. PDRB as a dependent variable while PMDN and PMA Investment Variable. Descriptive research methods for analyzing data with the Ordinary Least Square (OLS) method is a multiple linear regression. The results showed that PMDN had no significant effect on PDRB. There is a negative relationship between PMA and PDRB. Results of Research Analysis of multiple linear regressions that PMA has a significant effect on Economic Growth in Jambi Province. Based on the results of simultaneous tests that the variables PMDN and PMA simultaneously have a significant effect on the Economy of Jambi Province. While partially variable PMDN has a negative but insignificant effect on the Economy of Jambi Province. Recommendations ; The local government is expected to increase investment in Domestic Investment (PMDN) in Jambi Province through policies by creating a conducive investment climate, simplifying the licensing process, improving infrastructure, and improving the quality of human resources so that it is expected that the value of Investment can increase and can encourage the Economy of Jambi Province.
Pengaruh Kompetensi, Motivasi dan Disiplin Kerja terhadap Kinerja Karyawan (Studi Kasus Karyawan Perusahaan Pembiayaan Kota Jambi)
Authors: Fathiyah Fathiyah , Masnun Masnun , Syekh Saiyid
Published: July 2022

The purpose of this study is to see the extent to which competence, motivation and discipline affect employee performance, the analysis unit in this study is employees who work in financing companies in Jambi City, the sample number of 67 respondents, data collection techniques using questionnaires and processed by using multiple linear regression analysis, the results of the study show that there is a positive and significant influence both partially and significantly. Simultaneously from the variables of competence, motivation and discipline to the performance of employees of financing companies in Jambi City.
Optimalisasi Peran Satuan Brimob Polda Sumut Dalam Penanggulangan Aksi Radikalisme
Authors: I Kadoli Mukhtar , Eddy Triono , Sahari Alpi
Published: July 2022

Perkembangan lingkungan strategis yang diiringi dengan maraknya isu globalisasi selain berdampak positif terhadap kehidupan masyarakat, juga telah membawa dampak  yang besar terhadap situasi kamtibmas. Dimana perkembangan tersebut seharusnya menjadikan tatanan masyarakat semakin maju dan berkembang serta terjaminnya keamanan dan ketertiban masyarakat, akan tetapi yang terjadi sebaliknya yaitu memunculkan berbagai gerakan-gerakan ekstrim dan radikal berbasis sosial dan keagamaan yang mengarah kepada bentuk dan tindakan yang tidak sejalan dengan nilai-nilai pancasila berupa aksi kekerasan, teror dan bentuk-bentuk gangguan lainnya yang mengakibatkan terganggunya siuasi kamtibmas yang kondusif. Penanggulangan radikalisme diarahkan untuk mengembangkan potensi dan kekuatan dalam menangkal, mencegah dan menanggulangi segala bentuk pelanggaran hukum dan bentuk-bentuk gangguan lainnya yang dapat meresahkan masyarakat dengan sasaran perioritas untuk dilaksanakan yang dilakukan secara profesional dan proporsional untuk terwujudnya daya cegah dan daya tangkal terhadap gangguan Kamtibmas yang berkadar tinggi yakni radikalisme dan intoleransi. Metode penelitian yang digunakan dalam penelitian tesis ini terdiri dari spesifikasi penelitian, sumber data, teknik pengumpulan data dan analisis data. Jenis penelitian yang digunakan adalah penelitian hukum normatif, yaitu penelitian hukum yang mempergunakan sumber data sekunder yang penekanannya pada teoritis dan analisis kualitatif yang juga disebut sebagai penelitian perpustakaan atau studi dokumen. Pemberlakuan Peraturan Presiden (Perpres) Nomor 7 Tahun 2021 tentang Rencana Aksi Nasional Pencegahan dan Penanggulangan Ekstrimisme Berbasis Kekerasan yang Mengarah pada Terorisme tidak diikuti dengan penjelasan secara rinci perihal kegiatan apa saja yang masuk kategori ekstrimisme sehingga terjadinya multi tafsir dan memunculkan stigmatisasi di masyarakat. Hal ini tentunya berimpilkasi terhapap upaya yang dilakukan oleh Polri khususnya Satbrimob dalam penanggulangan aksi radikalsime. Satbrimob Polda Sumatera Utara sesuai dengan tugas dan fungsinya dalam penanggulangan aksi radikalisme adalah  melaksanakan patroli kemitraan di setiap daerah rawan penyebaran dan kegiatan kelompok-kelompok radikal yang menjadi lingkup tugas dimasing-masing Batalyon sebagai salah satu implementasi program Quick Wins Renstra dan transformasi menuju Polri yang PRESISI yaitu “penertiban dan penegakkan hukum bagi organisasi radikaldan anti pancasila
PEGEKAN HUKUM TERHADAP TAMBANG MINYAK ILEGAL DI WILAYAH HUKUM POLDA JAMBI
Authors: Gani Ruslan Abdul , Wardani Retno Kusuma
Published: July 2022

Banyaknya   sumber  minyak  yang  ada  di Kabupaten Batang Hari  sehingga  berpotensi  timbulnya  Illegal drilling  yakni aktivitas penambangan minyak yang dilakukan secara ilegal dengan mengeksplorasi dan mengolah minyak dari sumur tua maupun  membuat sumur baru tanpa izin. Setidaknya terdapat 3000  (tiga ribu) titik sumur ilegal yang ironisnya telah masuk ke dalam kawasan hutan lindung dan hutan restorasi yang dilindungi oleh negara.  Undang-Undang  Nomor  22  Tahun  2001  tentang  Minyak  dan  Gas  Bumi,melarang dilakukanya penambangan minyak secara illegal hal ini sebagaimana  diatur  dalam Pasal 52. “Setiap orang yang melakukan Eksplorasi dan/atau Eksploitasi tanpa mempunyai Kontrak Kerja Sama sebagaimana dimaksud dalam Pasal 11 ayat (1) dipidana dengan pidana penjara paling lama 6 (enam) tahun dan denda paling tinggi Rp.60.000.000.000,00 (enam puluh miliar rupiah).  Penegakan  hukum  terhadap  pelaku  Tindak Pidana penambangan  minyak  diwilayah hukum Polda  Jambi  khususnya  yang terjadi di Batang Hari,  kurun  waktu  3 (tiga)  tahun  terakhir  ini  yakni tahun  2018 s/d 2020 telah  dilakukan  dimana  ada 16. Permasalahan    yang  ditemui  oleh Kepolisian Daerah   Jambi  antara   lain, Masalah  penegakan hukum, masih terbatas, sarana  atau fasilitas yang  mendukung penegakan hukum masih kuran,  dilihat  dari  faktor masyarakat  dan budaya Masyarakat, dimana penambang minyak ilegal  sudah menjadi kebiasaan masyarakat, sehingga  sulit untuk  di cegah
EFEKTIIVITAS PENGGUNAAN GAME EDUKASI QUIZWHIZZER UNTUK MENINGKATKAN PEMAHAMAN KONSEP TEOREMA PHYTAGORAS
Authors: Faijah Nuthfah , Nuryadi Nuryadi , Hetty Marhaeni Nafida
Published: July 2022

Tujuan penelitian ini adalah mengetahui efektivitas penggunaan game edukasi berbantuan QuizWhizzer untuk meningkatkan kemampuan pemahaman konsep matematis siswa kelas VIII SMP pada materi teorema Pythagoras. Jenis penelitian ini adalah penelitian eksperimen dengan desain pretest posttest control group design. Sampel dalam penelitian ini adalah kelas VIII-H (kelas eksperimen) dan kelas VIII-G (kelas kontrol) di SMP Negeri 8 Yogyakarta. Teknik pengumpulan data menggunakan wawancara, observasi, soal pretest dan posttest kemampuan pemahaman konsep matematika. Hasil penelitian menunjukkan bahwa penggunaan game edukasi berbantuan QuizWhizzer lebih efektif untuk meningkatkan kemampuan pemahaman konsep siswa daripada pembelajaran secara langsung. Hal ini didukung dengan hasil analisis datta dimana berdasarkan uji independent sample t-tetst menunjukkan bahwa signifikansi (2-tailed) kurang dari signifikansi   , hal ini berarti penggunaan game edukasi berbantuan QuizWhizzer lebih efektif daripada kelas yang tidak menggunakan game edukasi berbantuan QuizWhizzer. Selain itu, berdasarkan uji perbedaan rata-rata juga menunjukkan bahwa peningkatan rata-rata untuk kelas eksperimen lebih besar dibandingkan peningkatan rata-rata kelas kontrol . Oleh karena itu, kemampuan pemahaman konsep siswa dapat meningkat dengan penggunaan game edukasi berbantuan QuizWhizzer saat pembelajaran matematika pada materi teorema Pythagoras.
Evaluasi Penerapan Green Construction Proyek Pembangunan Gedung Rektorat Kampus UIII
Authors: Suripto Suripto , Abdi Muhammad Haikal , Manurung Edison Hatoguan
Published: July 2022

Pemanasan global dan kerusakan pada lingkungan menjadi fenomena yang sering terjadi di dunia ini. Perkembangan dunia konstruksi menjadi salah satu alasan atas penyebab terjadinya fenomena tersebut. Oleh karena itu, dibutuhkan suatu konsep pembangunan yang dapat mengurangi kerusakan lingkungan serta memperhatikan kondisi lingkungan sekitar selama proses pembangunan. Green Building merupakan sebuah konsep pembangunan yang memerhatikan lingkungan sekitar, sebuah gedung dapat dikatakan sebagai greenbuilding apabila memenuhi penerapan green construction. Terdapat beberapa kategori green construction. Pada penelitian kali ini dibahas evaluasi penerapan green construction untuk mengetahui kategori apa yang dapat diterapkan dan mengukur tingkat prosentase pencapaian kategori green construction pada proyek pembangunan Gedung Rektorat Kampus Universitas Islam Internasional Indonesia berdasarkan Greenship New Building Versi 1.2. Metode yang digunakan yaitu analisa kualitatif, kategori green construction didapatkan dari hasil survey pendahuluan kepada para responden yaitu 3 orang praktisi dan seorang akademisi. Kategori yang didapat berdasarkan hasil survey pendahuluan yaitu pengendalian lingkungan atas asap rokok, polutan kimia, tingkat pencahayaan dan polusi dari aktivitas konstruksi. Untuk kategori pengendalian lingkungan atas asap rokok, polutan kimia, dan tingkat pencahayaan sudah memenuhi tolak ukur Greenship dengan prosentase 100% serta untuk kategori polusi dari aktivitas konstruksi mendapat prosentase sebesasr 50%
Evaluasi Ruang Henti Khusus (RHK) Sepeda Motor Pada Simpang Tiga di Kota Jambi
Authors: Sahera Sahera , Ermadani Ermadani , Bahar Fetty Febriasti
Published: July 2022

Ruang henti khusus (RHK) sepeda motor ialah ruangan yang disediakan pada ujung mulut persimpangan hanya dikhususkan untuk sepeda motor pada saat lampu merah menyala. Di Kota Jambi hampir di setiap persimpangan telah diterapkan Ruang Henti Khusus (RHK) sepeda motor. Menurut pandangan dari masyarakat Kota Jambi RHK di persimpangan tersebut masih belum bisa digunakan sesuai fungsinya dikarenakan masih ada masyarakat yang tidak mengetahui apa fungsi dari RHK tersebut. Untuk meninjau hal tersebut penulis melakukan penelitian evaluasi penerapan RHK pada persimpangan bersinyal Simpang Tiga di Kota Jambi. Berdasarkan Hasil Penelitian Untuk dapat diketahui bahwa presentase tingkat keterisian RHK persimpangan simpang 3 Kota Jambi dari 13 simpang yang memiliki 36 pendekat yang memiliki RHK hanya beberapa simpang yang dikatakan berhasil dengan persentase ≥80% yaitu ada 8 pendekat simpang, yang dikatakan cukup berhasil dengan persentase 60%-79% ada 12 pendekat simpang, sedangkan yang tergolong kurang berhasil diterapkan dengan persentase <60% ada 13 pendekat simpang yang ada di Kota Jambi. Untuk penempatan RHK dilihat dari kondisi lalu lintas ada di persimpangan simpang 3 di Kota Jambi ada 9 simpang dengan 14 pendekat yang sesuai dengan persyaratan geometrik persimpangan dan ada 13 simpang dengan 29 pendekat yang memenuhi persyaratan kondisi lalu lintas sesuai dengan pedoman RHK 2015.
Implementasi Pembinaan Kepribadian dan Keterampilan terhadap Narapidana pada Lembaga Pemasyarakatan Kelas II A Jambi
Authors: Yanti Herma , Maryati Maryati , Yusriansyah Andika
Published: July 2022

Guidance of prisoners in Correctional Institutions is an important process in shaping personality as well as providing skills so that the stated coaching goals can be realized. For this reason, these coaching activities need to be carried out optimally according to the pattern of coaching as stipulated in the Decree of the Minister of Justice Number M.02-PK.04.10 of 1990, which includes personality development and skills development. Considering the large number of prisoners who are accommodated in the Jambi Class IIA Institute, this study aims to discuss how the implementation of personality development and skills development for these prisoners and other factors that also influence its implementation. Therefore, this study uses a socio legal research approach. To obtain field data, it was conducted through interviews with several correctional officers respondents who were considered relevant to the problem being studied. From the results of the study, it is known that the implementation of the guidance has not been optimally carried out. In addition to the main factor, the number of prisoners that far exceeds the capacity of the Correctional Institution so that it affects the availability of coaching facilities, it is also influenced by the staff's resource factor, and no less important is the quality of the resources involved in providing materials for some of the coaching activities carried out.
Sanksi Pidana Kerja Sosial terhadap Pengguna Knalpot Racing Sepeda Motor
Authors: Nurhasan Nurhasan
Published: July 2022

The existence of exhaust racing is currently very troubling to the community so that sanctions are needed in accordance with the actions committed by the violator. The type of research used in this research is normative juridical so that this research is more descriptive in nature, the data sources are primary, secondary and tertiary sources, then the research approach this is a statutory approach, the data collection technique in this research is a document study and the data analysis in this research is carried out qualitatively. The results show that the regulation of criminal sanctions against motorcycle racing exhaust users in Law Number 22 of 2009 concerning Road Traffic and Transportation is regulated in Article 285 paragraph (1) of Law Number 22 of 2009 concerning Road Traffic and Transportation. Then the impact of motorcycle racing exhaust users is that it can pollute the air and cause noise pollution. For perpetrators of violations of motorcycle racing exhaust users, the sanctions imposed include bringing the racing exhaust closer to the ears of the motorcycle racing exhaust user, doing push-ups and the like which can be categorized as sports and sweeping on the roadside, assisting the environmental cleaning service to clean the city and others.
Improving the anti-acute myeloid leukemia activity of CD123-specific engager T cells by MyD88 and CD40 costimulation
Authors: Vaidya Abishek , Doherty Erin , Wu Xiya , Huang Sujuan , Hebbar Nikhil , Thanekar Unmesha , Bonifant Challice L. , Cheng Cheng , Gottschalk Stephen , Velasquez M. Paulina
Published: July 2022

The outcome of patients with acute myeloid leukemia remains poor, and immunotherapy has the potential to improve this. T cells expressing chimeric antigen receptors or bispecific T-cell engagers targeting CD123 are actively being explored in preclinical and/or early phase clinical studies. We have shown that T cells expressing CD123-specific bispecific T-cell engagers (CD123.ENG T cells) have anti-acute myeloid leukemia activity. However, like chimeric antigen receptor T cells, their effector function diminishes rapidly once they are repeatedly exposed to antigen-positive target cells. Here we sought to improve the effector function of CD123.ENG T cells by expressing inducible co-stimulatory molecules consisting of MyD88 and CD40 (iMC), MyD88 (iM), or CD40 (iC), which are activated by a chemical inducer of dimerization. CD123.ENG T cells expressing iMC, iM, or iC maintained their antigen specificity in the presence of a chemical inducer of dimerization, as judged by cytokine production (interferon-γ, interleukin-2) and their cytolytic activity. In repeat stimulation assays, activating iMC and iM, in contrast to iC, enabled CD123.ENG T cells to secrete cytokines, expand, and kill CD123-positive target cells repeatedly. Activating iMC in CD123.ENG T cells consistently improved antitumor activity in an acute myeloid leukemia xenograft model. This translated into a significant survival advantage in comparison to that of mice that received CD123.ENG or CD123.ENG.iC T cells. In contrast, activation of only iM in CD123.ENG T cells resulted in donor-dependent antitumor activity. Our work highlights the need for both toll-like receptor pathway activation via MyD88 and provision of co-stimulation via CD40 to consistently enhance the antitumor activity of CD123.ENG T cells.
Analysis of rare driving events in pediatric acute myeloid leukemia
Authors: Noort Sanne , Oosterwijk Jolieke van , Ma Jing , Garfinkle Elizabeth A.R. , Nance Stephanie , Walsh Michael , Song Guangchun , Reinhardt Dirk , Pigazzi Martina , Locatelli Franco , Hasle Henrik , Abrahamsson Jonas , Jarosova Marie , Kelaidi Charikleia , Polychronopoulou Sophia , Van den Heuvel-Eibrink Marry M. , Fornerod Maarten , Gruber Tanja A. , Zwaan C. Michel
Published: July 2022

Elucidating genetic aberrations in pediatric acute myeloid leukemia (AML) provides insight in biology and may impact on risk-group stratification and clinical outcome. This study aimed to detect such aberrations in a selected series of samples without known (cyto)genetic aberration using molecular profiling. A cohort of 161 patients was selected from various study groups: DCOG, BFM, SJCRH, NOPHO and AEIOP. Samples were analyzed using RNA sequencing (n=152), whole exome (n=135) and/or whole genome sequencing (n=100). In 70 of 156 patients (45%), of whom RNA sequencing or whole genome sequencing was available, rearrangements were detected, 22 of which were novel; five involving ERG rearrangements and four NPM1 rearrangements. ERG rearrangements showed self-renewal capacity in vitro, and a distinct gene expression pattern. Gene set enrichment analysis of this cluster showed upregulation of gene sets derived from Ewing sarcoma, which was confirmed comparing gene expression profiles of AML and Ewing sarcoma. Furthermore, NPM1-rearranged cases showed cytoplasmic NPM1 localization and revealed HOXA/B gene overexpression, as described for NPM1 mutated cases. Single-gene mutations as identified in adult AML were rare. Patients had a median of 24 coding mutations (range, 7-159). Novel recurrent mutations were detected in UBTF (n=10), a regulator of RNA transcription. In 75% of patients an aberration with a prognostic impact could be detected. Therefore, we suggest these techniques need to become standard of care in diagnostics.
Editorial Vol13(2)
Authors: Talukder Md Humayun Kabir
Published: July 2022

Abstract not available
Bangladesh Journal of Medical Education Vol.13(2) July 2022: 1-2
Paleogeomorfologi Formasi Cibodas dan Catatan Temuan Fosil Gigi Hiu di Daerah Gunung Sungging dan Sekitarnya, Kabupaten Sukabumi, Jawa Barat
Authors: Winarto Johan Budi
Published: July 2022

Fosil gigi hiu ditemukan oleh masyarakat di Desa Gunung Sungging, Kecamatan Surade, Kabupaten Sukabumi, Jawa Barat. Fosil tersingkap pada batupasir tufan, anggota Formasi Cibodas berumur Pliosen dengan lingkungan pengendapan transisi-neritik. Morfologi daerah penyelidikan merupakan dataran sampai perbukitan dan dikontrol oleh struktur sesar normal yang tersingkap di sungai Cikarang. Kajian paleogeomorfologi ditentukan melalui analisis bentangalam, struktur geologi, stratigrafi serta paleontologi. Bentangalam daerah penyelidikan menunjukkan perubahan lingkungan pengendapan dari laut ke darat, yang dibatasi oleh singkapan Formasi Cibodas. Formasi ini terdiri atas satuan batupasir gampingan dan tuf. Sekitar 120 fosil hiu telah dikumpulkan selama penyelidikan lapangan, dan dianalisis berdasarkan karakteristik, morfologi, dan dimensi ukurannya. Fosil gigi Otodus megalodon berjumlah 19 buah, dan 101 buah lainnya adalah jenis gigi non-Otodus megalodon. Semua fosil ditemukan di Formasi Cibodas bagian bawah. Pada kala Pliosen, kawasan ini diinterpretasikan sebagai kawasan teluk dan laguna yang menjadi tempat cocok bagi kehidupan hiu.Keywords: Bentuk lahan, fosil gigi hiu, paleogeomorfologi, stratigrafi.
Pemisahan Menggunakan Polynomial Fitting dan Analisis Second Vertical Derivative (SVD) untuk Mengidentifikasi Patahan pada Lapangan Panasbumi Pulau Pantar, Kabupaten Alor
Authors: Charisma A.W Puja , Zarkasyi Ahmad , - Suharno , Haerudin Nandi
Published: July 2022

- Pulau Pantar, Kabupaten Alor, Nusa Tenggara Timur berada di lingkungan vulkanik Kuarter yang memiliki potensi panasbumi yang diindikasikan adanya manifestasi panas bumi diantaranya fumarola, solfatara, tanah panas, dan air panas. Manisfestasi tersebut dapat muncul ke permukaan karena keberadaan struktur geologi berupa patahan. Selain manisfestasi, patahan pada sistem panas bumi berperan penting dalam proses resapan pada daerah pengisian. Salah satu metode yang dapat digunakan untuk mengidentifikasi struktur geologi adalah metode gayaberat. Identifikasi struktur patahan pada survei ini dilakukan dengan mengkorelasikan pemodelan gaya berat 2D dan 3D. Pemisahan anomali Bouger dilakukan dengan polynomial fitting. Pada lintasan pertama diidentifikasi terdapat 4 litologi antara lain ada Vulkanik Tua Kongmauwas (VTKG), Aliran Piroklastik Sirung Tua (StAl), Batugamping (Bgp), dan Vulkanik Tua Kalondama (VTKl). Pada lintasan kedua terdapat 4 litologi diantaranya terdapat Vulkanik Tua Kongmauwas (VTKG), Aliran Piroklastik Sirung Tua (StAl), Jatuhan Piroklastik (SAj), dan Vulkanik Tua Kalondama (VTKl). Berdasarkan hasil pemodelan dan analisis data gayaberat diidentifikasi terdapat 4 struktur patahan pada lintasan AB yang telah dikorelasikan dengan peta geologi, dan terdapat 2 patahan pada anomali rendah dan 2 patahan pada anomali tinggi yang salah satu patahannya terdapat pada manifestasi air panas dan untuk lintasan CD diidentifikasi terdapat 3 struktur patahan untuk 2 patahan terdapat pada anomali tinggi dan 1 patahan terdapat pada anomali rendah.KataKunci: Gayaberat, Geothermal, Pulau Pantar, Polynomial Fitting.
Compostos bioativos presentes no azeite de oliva e seus subprodutos: revisão bibliográfica
Authors: Basso Cristiana , Uliana Greici C. , Richards Neila S. P. S.
Published: July 2022

O objetivo do estudo foi investigar acerca do que está sendo questionado por renomados pesquisadores em todas as partes do mundo, ou seja, especular em relação aos países que mais publicam quando o assunto se refere a azeite e seus subprodutos, quais são os maiores produtores, qual a qualidade desses produtos oferecidos ao mercado, quais as melhores técnicas para preservar os compostos benéficos à saúde, além de lacunas que possam instigar a mais pesquisas elucidativas. Ocorreu através de revisão da literatura, utilizando os descritores ¨Azeite de Oliva¨ e ¨Bioativos¨. A pesquisa foi refinada almejando como forma de documento somente artigos, estes com publicação nos anos de 2021 e 2022. Posteriormente os artigos selecionados foram direcionados para análise bibliométrica. Em posse dos 109 artigos pré-selecionados, fez-se um novo refinamento, analisando-se então 78 artigos, os quais foram categorizados em cinco tópicos de maior importância: Resíduos da produção do azeite de oliva, processo tecnológico para análise do azeite, parâmetros químicos de diferentes cultivares, compostos bioativos, processo para determinação dos compostos bioativos. Após análise minuciosa de todos os artigos selecionados, referente inicialmente a compostos bioativos e azeite de oliva, e no decorrer adicionado subprodutos da produção do azeite, pode-se comprovar acerca dos benefícios dos compostos bioativos, formas de melhor preservá-los, além de algumas tendências em relação a sustentabilidade e preservação do meio ambiente, e por fim, identificação de métodos que podem se tornar promissores: bioinformática a fim de predizer propriedades medicinais e análise sensorial corroborando com técnicas analíticas e químicas.
Decreased vitamin D-binding protein level portends poor outcome in acute-on-chronic liver failure caused by hepatitis B virus
Authors: Wu Daxian , Rao Qunfang , Xie Zhongyang , Zhu Xiaoqing , Che Yuanmei , Wu Jian , Gao Hainv , Zhang Jingyu , Hou Zhouhua , Cheng Xiaoyu , Sun Zeyu
Published: July 2022

Background/Aims: Acute-on-chronic liver failure (ACLF) is a catastrophic illness. Few studies investigated the prognostic value of vitamin D-binding protein (VDBP) for hepatitis B virus (HBV)-related ACLF (HBV-ACLF) resulted in conflicting results.Methods: Two prospective HBV-ACLF cohorts (n=287 and n=119) were enrolled to assess and validate the prognostic performance of VDBP.Results: VDBP levels in the non-survivors were significantly lower than in the survivors (P<0.001). Multivariate Cox regression demonstrated that VDBP was an independent prognostic factor for HBV-ACLF. The VDBP level at admission gradually decreased as the number of failed organs increased (P<0.001), and it was closely related to coagulation failure. The areas under the receiver operating characteristic curve (AUCs) of the Child-Pugh-VDBP and chronic liver failuresequential organ failure assessment (CLIF–SOFA)-VDBP scores were significantly higher than those of Child-Pugh (P<0.001) and CLIF-SOFA (P=0.0013). The AUCs of model for end-stage liver disease (MELD)-VDBP were significantly higher than those of MELD (P= 0.0384) only in the case of cirrhotic HBV-ACLF patients. Similar results were validated using an external multicenter HBV-ACLF cohort. By longitudinal observation, the VDBP levels gradually increased in survivors (P=0.026) and gradually decreased in non-survivors (P<0.001). Additionally, the VDBP levels were found to be significantly decreased in the deterioration group (P=0.012) and tended to be decreased in the fluctuation group (P=0.055). In contrast, they showed a significant increase in the improvement group (P=0.036).Conclusions: The VDBP was a promising prognostic biomarker for HBV-ACLF. Sequential measurement of circulating VDBP shows value for the monitoring of ACLF progression.
Quantifying the historical development of recreational fisheries in Southeast Queensland, Australia
Authors: Chong-Montenegro C , Thurstan RH , Pandolfi JM
Published: July 2022

Recreational fisheries are of global socio-ecological importance and contribute significantly to local economies and fisheries harvests. In some regions of Australia, organized recreational fishing activities have existed for over 150 yr. However, historical understanding of the spatio-temporal development and resource usage of recreational fisheries has been hampered by the lack of continuous time-series catch and effort data. This study used historical newspaper articles of reported landings by fishing clubs to reconstruct catch rate trends and evaluate changes in catch composition of marine recreational fishing activities in Moreton Bay, Queensland, Australia, from 1920-1984. Using generalized additive mixed models, 2 catch rate metrics (no. of fish fisher-1 trip-1 and kg fish fisher-1 trip-1) were constructed as functions of time and distance travelled. Significant nonlinear relationships were found for no. of fish fisher-1 trip-1. Fluctuations in no. of fish fisher-1 trip-1 were strongly influenced by time, while increases in distance travelled predicted a larger no. of fish fisher-1 trip-1. Measures of kg fish fisher-1 trip-1 were tightly linked to increases in distance travelled but did not vary with time. Spatial analysis revealed shifts in areas fished, from inshore reefs during the 1920s and 1930s (pre-WWII) towards isolated offshore island systems in later decades (>1950s; post-WWII). Reported catches pre-WWII were strongly associated with reef species, while reported catches post-WWII were predominantly characterized by demersal coastal fish. Spatially resolved time-series fisheries data can be reconstructed from archival sources, providing valuable information about the development of recreational fishing activities and explaining the historical social-ecological dynamics that led to current ecosystem states.
Functional comparison of anti-restriction and anti-methylation activities of ArdA, KlcA, and KlcAHS from Klebsiella pneumoniae
Authors: Chen Huimin , Tao Shuan , Li Na , Wang Fang , Wang Lei , Tang Yu , Liang Wei
Published: July 2022

Anti-restriction proteins are typically encoded by plasmids, conjugative transposons, or phages to improve their chances of entering a new bacterial host with a type I DNA restriction and modification (RM) system. The invading DNA is normally destroyed by the RM system. The anti-restriction proteins ArdA, KlcA, and their homologues are usually encoded on plasmid of carbapenemase-resistant Klebsiella pneumoniae. We found that the plasmid sequence and restriction proteins affected horizontal gene transfer, and confirmed the anti-restriction and anti-methylation activities of ArdA and KlcA during transformation and transduction. Among the three anti-restriction proteins, ArdA shows stronger anti-restriction and anti-methylation effects, and KlcAHS was weaker. KlcA shows anti-methylation only during transformation. Understanding the molecular mechanism underlying the clinical dissemination of K. pneumoniae and other clinically resistant strains from the perspective of restrictive and anti-restrictive systems will provide basic theoretical support for the prevention and control of multidrug-resistant bacteria, and new strategies for delaying or even controlling the clinical dissemination of resistant strains in the future.
Establishment of a rapid diagnosis method for Candida glabrata based on the ITS2 gene using recombinase polymerase amplification combined with lateral flow strips
Authors: Wang Kun , Huo Li , Li Yuanyuan , Zhu Lihua , Wang Yan , Wang Lei
Published: July 2022

Candida glabrata is the second or third most common Candida-associated species isolated from hospital-acquired infections, surpassing even C. albicans in some hospitals. With the rapid progression of the disease course of C. glabrata infections, there is an urgent need for a rapid and sensitive on-site assay for clinical diagnosis. Isothermal amplification is a recently developed method for rapid nucleic acid detection that is being increasingly used for on-site detection, especially recombinase polymerase amplification (RPA). RPA combined with lateral flow strips (LFS) can rapidly amplify and visually detect the target gene within 20 min. The whole detection process can be controlled within 30–60 min by rapid sample pre-treatment. In this study, RPA-LFS was used to amplify the internal transcribed spacer region 2 gene of C. glabrata. The primer–probe design was optimized by introducing base mismatches (probe modification of one base) to obtain a highly specific and sensitive primer–probe combination for clinical sample detection. RPA-LFS was performed on 23 common clinical pathogens to determine the specificity of the assay system. The RPA-LFS system specifically detected C. glabrata without cross-reaction with other fungi or bacteria. Gradient dilutions of the template were tested to explore the lower limit of detection of this detection system and to determine the sensitivity of the assay. The sensitivity was 10 CFU/µL, without interference from genomic DNA of other species. The RPA-LFS and qPCR assays were performed on 227 clinical samples to evaluate the detection performance of the RPA-LFS system. Eighty-five samples were identified as C. glabrata, representing a detection rate of 37.5%. The results were consistent with qPCR and conventional culture methods. The collective findings indicate a reliable molecular diagnostic method for the detection of C. glabrata, and to meet the urgent need for rapid, specific, sensitive, and portable clinical field-testing.
Role of HPV16 E1 in cervical carcinogenesis
Authors: Baedyananda Fern , Sasivimolrattana Thanayod , Chaiwongkot Arkom , Varadarajan Shankar , Bhattarakosol Parvapan
Published: July 2022

Cervical cancer is the fourth most common cancer in women worldwide. More than 90% of cases are caused by the human papillomavirus (HPV). Vaccines developed only guard against a few HPV types and do not protect people who have already been infected. HPV is a small DNA virus that infects the basal layer of the stratified epithelium of the skin and mucosa through small breaks and replicates as the cells differentiate. The mucosal types of HPV can be classified into low-risk and high-risk groups, based on their association with cancer. Among HPV types in high-risk group, HPV type 16 (HPV-16) is the most common, causing 50% of all cancer cases. HPV infection can occur as transient or persistent infections, based on the ability of immune system to clear the virus. Persistent infection is characterized by the integration of HPV genome. HPV-16 exhibits a different integration pattern, with only 50% reported to be integrated at the carcinoma stage. Replication of the HPV genome depends on protein E1, an ATP-dependent helicase. E1 is essential for the amplification of the viral episome in infected cells. Previous studies have shown that E1 does not only act as a helicase protein but is also involved in recruiting and interacting with other host proteins. E1 has also been deemed to drive host cell proliferation. Recent studies have emphasized the emerging role of HPV E1 in cervical carcinogenesis. In this review, a possible mechanism by which E1 drives cell proliferation and oncogenesis will be discussed.
Spatio-temporal characteristics of hazardous weather affecting Chinese airports based on the ERA5/ERA5-land reanalysis dataset
Authors: Lei Ting , Jin Chenxi , Qi Chen
Published: July 2022

The growing demand for air transportation has led to increased air traffic and airline operations at airports worldwide, while hazardous weather conditions have a considerable impact on the efficiency and safety of air traffic. The long-term and high-resolution state-of-art fifth-generation reanalysis of the European Center for Medium-Range Weather Forecasts (ECMWF) (ERA5) and ERA5-land provide us a perspective on the climatological characteristics of hazardous weather conditions affecting Chinese airports. These hazardous weather conditions include low-level wind shear (LLWS), limited visibility (LIMV), thunderstorms (TSTMs), and snowfall (SNOW). The LLWS is frequent in winter but rare in summer. At the airports in the north of eastern China, managers should take more precautions about LLWS from February to March and October to November. LIMV is major hazardous weather in the south of eastern China that should be carefully monitored in winter, especially from December to January. In northwestern China, LIMV is rare, especially at Yinchuan and Lanzhou airports. TSTMs frequently occur in South China and Southwest China, especially in Yunnan, Guangxi, Guangdong, and eastern Tibet. The corresponding active period is summer. SNOW frequently occurs over the Tibet Plateau and parts of Xinjiang province. SNOW is generally active in early winter (December–January) at Urumchi airport but at Lhasa airport in late winter (February–March). There is no SNOW throughout the year in the south of eastern China. The observations also verify such characteristics of the annual cycles of the four hazardous weather conditions. The trend analysis does not express many warnings on hazardous weather conditions except the SNOW. The SNOW at Lhasa airport shows an increasing trend. Considering the frequent SNOW in Lhasa, more attention should be put to monitoring this weather here.
Warm beach, warmer turtles: Using drone-mounted thermal infrared sensors to monitor sea turtle nesting activity
Authors: Sellés-Ríos Bárbara , Flatt Eleanor , Ortiz-García Johan , García-Colomé Júlia , Latour Orane , Whitworth Andrew
Published: July 2022

For decades sea turtle projects around the world have monitored nesting females using labor-intensive human patrolling techniques. Here we describe the first empirical testing of a drone-mounted thermal infrared sensor for nocturnal sea turtle monitoring; on the Osa peninsula in Costa Rica. Preliminary flights verified that the drone could detect similar sea turtle activities as identified by on-the-ground human patrollers – such as turtles, nests and tracks. Drone observers could even differentiate tracks of different sea turtle species, detect sea turtle hatchlings, other wildlife, and potential poachers. We carried out pilot flights to determine optimal parameters for detection by testing different thermal visualization modes, drone heights, and gimbal angles. Then, over seven nights, we set up a trial to compare the thermal drone and operators’ detections with those observed by traditional patrollers. Our trials showed that thermal drones can record more information than traditional sea turtle monitoring methods. The drone and observer detected 20% more sea turtles or tracks than traditional ground-based patrolling (flights and patrols carried out across the same nights at the same time and beach). In addition, the drone operator detected 39 other animals/predators and three potential poachers that patrollers failed to detect. Although the technology holds great promise in being able to enhance detection rates of nesting turtles and other beach activity, and in helping to keep observers safer, we detail challenges and limiting factors; in drone imagery, current cost barriers, and technological advances that need to be assessed and developed before standardized methodologies can be adopted. We suggest potential ways to overcome these challenges and recommend how further studies can help to optimize thermal drones to enhance sea turtle monitoring efforts worldwide.
Machine learning algorithms to predict major bleeding after isolated coronary artery bypass grafting
Authors: Gao Yuchen , Liu Xiaojie , Wang Lijuan , Wang Sudena , Yu Yang , Ding Yao , Wang Jingcan , Ao Hushan
Published: July 2022

Objectives

Postoperative major bleeding is a common problem in patients undergoing cardiac surgery and is associated with poor outcomes. We evaluated the performance of machine learning (ML) methods to predict postoperative major bleeding.

Methods

A total of 1,045 patients who underwent isolated coronary artery bypass graft surgery (CABG) were enrolled. Their datasets were assigned randomly to training (70%) or a testing set (30%). The primary outcome was major bleeding defined as the universal definition of perioperative bleeding (UDPB) classes 3–4. We constructed a reference logistic regression (LR) model using known predictors. We also developed several modern ML algorithms. In the test set, we compared the area under the receiver operating characteristic curves (AUCs) of these ML algorithms with the reference LR model results, and the TRUST and WILL-BLEED risk score. Calibration analysis was undertaken using the calibration belt method.

Results

The prevalence of postoperative major bleeding was 7.1% (74/1,045). For major bleeds, the conditional inference random forest (CIRF) model showed the highest AUC [0.831 (0.732–0.930)], and the stochastic gradient boosting (SGBT) and random forest models demonstrated the next best results [0.820 (0.742–0.899) and 0.810 (0.719–0.902)]. The AUCs of all ML models were higher than [0.629 (0.517–0.641) and 0.557 (0.449–0.665)], as achieved by TRUST and WILL-BLEED, respectively.

Conclusion

ML methods successfully predicted major bleeding after cardiac surgery, with greater performance compared with previous scoring models. Modern ML models may enhance the identification of high-risk major bleeding subpopulations.