bluuebunny/crossref_metadata_2025 huggingface dataset:
Comprehensive Review of Islanding Detection Methods for Distributed Generation Systems
Authors: Kim Min-Sung , Haider Raza , Cho Gyu-Jung , Kim Chul-Hwan , Won Chung-Yuen , Chai Jong-Seo
Published: March 2019

The increased penetration of distributed generation (DG), renewable energy utilization, and the introduction of the microgrid concept have changed the shape of conventional electric power networks. Most of the new power system networks are transforming into the DG model integrated with renewable and non-renewable energy resources by forming a microgrid. Islanding detection in DG systems is a challenging issue that causes several protection and safety problems. A microgrid operates in the grid-connected or stand-alone mode. In the grid-connected mode, the main utility network is responsible for a smooth operation in coordination with the protection and control units, while in the stand-alone mode, the microgrid operates as an independent power island that is electrically separated from the main utility network. Fast islanding detection is, therefore, necessary for efficient and reliable microgrid operations. Many islanding detection methods (IdMs) are proposed in the literature, and each of them claims better reliability and high accuracy. This study describes a comprehensive review of various IdMs in terms of their merits, viability, effectiveness, and feasibility. The IdMs are extensively analysed by providing a fair comparison from different aspects. Moreover, a fair analysis of a feasible and economical solution in view of the recent research trend is presented.
Noise Assessment of Small Vessels for Action Planning in Canal Cities
Authors: Bernardini Marco , Fredianelli Luca , Fidecaro Francesco , Gagliardi Paolo , Nastasi Marco , Licitra Gaetano
Published: March 2019

After the European Environmental Noise Directive prescribed noise maps and action plans, wide scientific literature and a consistent number of mitigation strategies emerged for road, railway, airport, and industrial noise. Unfortunately, very little attention has been paid to the noise produced by ports in their surroundings, even though there could be many areas affected by it. At present, more attention seems to be paid to noise produced underwater, mostly for military and security reasons and for its interference with wildlife, rather than airborne noise and its influence on human health. In the framework of a project aiming to shed more light on a topic so far under-investigated, this paper presents an acoustical characterization of different small vessels at various speeds that move around on a daily basis in every type of port, produced by means of short- and long-term measurements. The new information acquired was used to produce a map of noise generated by vessels moving in Livorno’s canals, which branch off in a densely inhabited area. The simulations were validated using long-term measurement. The number of citizens exposed was also estimated and used to calculate the number of highly annoyed people according to the recent curve for road traffic noise proposed by Guski et al. In order to prevent citizen exposure to noise and possible complaints about small boats, different scenarios and possible future situations such as various vessel speeds, limited flow, restricted areas for some categories, or new residential areas were studied.
Pinus massoniana Introgression Hybrids Display Differential Expression of Reproductive Genes
Authors: Mo Jiaxing , Xu Jin , Cao Yuting , Yang Liwei , Yin Tongming , Hua Hui , Zhao Hui , Guo Zhenhao , Yang Junjie , Shi Jisen
Published: March 2019

Pinus massoniana and P. hwangshanensis are two conifer species located in southern China, which are of both economic and ornamental value. Around the middle and lower reaches of the Yangtze River, P. massoniana occurs mainly at altitudes below 700 m, while P. hwangshanensis can be found above 900 m. At altitudes where the distribution of both pines overlaps, a natural introgression hybrid exists, which we will further refer to as the Z pine. This pine has a morphological character that shares attributes of both P. massoniana and P. hwangshanensis. However, compared to the other two pines, its reproductive structure, the pinecone, has an ultra-low ripening rate with seeds that germinate poorly. In this study, we aimed to find the reason for the impaired cone maturation by comparing transcriptome libraries of P. massoniana and Z pine cones at seven successive growth stages. After sequencing and assembly, we obtained unigenes and then annotated them against NCBI’s non-redundant nucleotide and protein sequences, Swiss-Prot, Clusters of Orthologous Groups, Gene Ontology and KEGG Orthology databases. Gene expression levels were estimated and differentially expressed genes (DEGs) of the two pines were mined and analyzed. We found that several of them indeed relate to reproductive process. At every growth stage, these genes are expressed at a higher level in P. massoniana than in the Z pine. These data provide insight into understanding which molecular mechanisms are altered between P. massoniana and the Z pine that might cause changes in the reproductive process.
Generation of Wave Groups by Shear Layer Instability
Authors: Grimshaw Roger
Published: March 2019

The linear stability theory of wind-wave generation is revisited with an emphasis on the generation of wave groups. The outcome is the fundamental requirement that the group move with a real-valued group velocity. This implies that both the wave frequency and the wavenumber should be complex-valued, and in turn this then leads to a growth rate in the reference frame moving with the group velocity which is in general different from the temporal growth rate. In the weakly nonlinear regime, the amplitude envelope of the wave group is governed by a forced nonlinear Schrödinger equation. The effect of the wind forcing term is to enhance modulation instability both in terms of the wave growth and in terms of the domain of instability in the modulation wavenumber space. Also, the soliton solution for the wave envelope grows in amplitude at twice the linear growth rate.
The Complete Mitochondrial Genome Sequences of the Philomycus bilineatus (Stylommatophora: Philomycidae) and Phylogenetic Analysis
Authors: Yang Tiezhu , Xu Guolyu , Gu Bingning , Shi Yanmei , Mzuka Hellen Lucas , Shen Heding
Published: March 2019

The mitochondrial genome (mitogenome) can provide information for phylogenetic analyses and evolutionary biology. We first sequenced, annotated, and characterized the mitogenome of Philomycus bilineatus in this study. The complete mitogenome was 14,347 bp in length, containing 13 protein-coding genes (PCGs), 23 transfer RNA genes, two ribosomal RNA genes, and two non-coding regions (A + T-rich region). There were 15 overlap locations and 18 intergenic spacer regions found throughout the mitogenome of P. bilineatus. The A + T content in the mitogenome was 72.11%. All PCGs used a standard ATN as a start codon, with the exception of cytochrome c oxidase 1 (cox1) and ATP synthase F0 subunit 8 (atp8) with TTG and GTG. Additionally, TAA or TAG was identified as the typical stop codon. All transfer RNA (tRNA) genes had a typical clover-leaf structure, except for trnS1 (AGC), trnS2 (TCA), and trnK (TTT). A phylogenetic analysis with another 37 species of gastropods was performed using Bayesian inference, based on the amino acid sequences of 13 mitochondrial PCGs. The results indicated that P. bilineatus shares a close ancestry with Meghimatium bilineatum. It seems more appropriate to reclassify it as Arionoidea rather than Limacoidea, as previously thought. Our research may provide a new meaningful insight into the evolution of P. bilineatus.
Adaptation and Validation of the Chinese Version of the Nutrition Environment Measurement Tool for Stores
Authors: Liu Yang , Song Shenzhi , Gittelsohn Joel , Jiang Nan , Hu Jiajin , Ma Yanan , Wen Deliang
Published: March 2019

Changes in lifestyle and food environment have created a heavy burden of obesity and chronic disease in China. However, measurements of the food environment have been rarely reported in China or other countries with similar food cultures; this measurement shortage is partially due to the lack of valid and reliable measurement tools. The aim of the present study was to adapt and validate a Chinese version of the Nutritional Environment Measurement Survey for Stores (C-NEMS-S). Categories and items of the NEMS-S were culturally adapted to fit the Chinese population and included grains, dry beans, starchy tubers, vegetables, fruits, seafood, meat and poultry, dietary oils, milk, bread, instant noodles, and beverages. A scoring sheet for each food category was created to measure availability, quality, and pricing. Then, the C-NEMS-S was validated in 10 large-sized supermarkets and 10 convenience stores in Shenyang, China. Two trained raters performed their evaluations separately at the same store. The intra-class correlation coefficient (ICC) of the availability composite score was 0.98. All food measures had a moderate or good ICC (0.41 to 1.00). The kappa for each food measure ranged from 0.52 to 1.00. C-NEMS-S was able to show the difference in healthy food availability between large-sized supermarkets and convenience stores, as well as the price differences between healthier options and regular options. Large-sized supermarkets had a significantly higher total score (p < 0.001) and healthier option availability for all food measures (all items were statistically significant (p < 0.05), except sugar-free beverages). Healthier options cost more than regular options for grains, milk, bread, and instant noodles (from 4% to 153%). The adapted C-NEMS-S can be used to measure the consumer food environment in stores in China.
Do Sociodemographic Factors and Urban Green Space Affect Mental Health Outcomes Among the Urban Elderly Population?
Authors: Lee Hyun Jin , Lee Dong Kun
Published: March 2019

The mounting mental health issues faced by elderly urban residents increase the social and economic costs to society associated with dementia and depression. Therefore, it is necessary to identify the characteristics of elderly urban residents suffering from mental health issues, to address these issues more effectively. We used 2015 Community Health Survey data from the Korea Centers for Disease Control and Prevention to identify the demographic and social characteristics of 11,408 elderly urban residents in relation to stress levels and symptoms of depression in seven metropolitan areas in Korea, and to calculate the odds ratio for urban green space. We found that the prevalence of these mental health issues generally decreased in relation to the ratio of green space of an area. These findings suggest identifying elderly people who are vulnerable to certain mental health issues based on demographic and social characteristics and demonstrate that the ratio of urban green space within a community is an important component in improving mental health outcomes for elderly urban residents. These findings have policy implications for assisting elderly people vulnerable to certain mental health issues and for establishing a green welfare policy targeting this population.
Is Repeat Abortion a Public Health Problem among Chinese Adolescents? A Cross-Sectional Survey in 30 Provinces
Authors: Liu Jinlin , Wu Shangchun , Xu Jialin , Temmerman Marleen , Zhang Wei-Hong ,   The INPAC Group
Published: March 2019

The Chinese Family Planning (FP) programme mainly focuses on married couples, and young unmarried women have limited access. This cross-sectional study aims to identify risk factors related to repeat abortions in Chinese adolescents receiving abortions. Data were collected using a questionnaire for all women seeking abortions within 12 weeks of pregnancy during a period of 2 months in 297 participating hospitals randomly selected across 30 provinces of China in 2013. Only the adolescents (younger than the minimum legal married age of 20 years) were included in this study. Of the 2370 adolescents who were receiving abortions, 927 (39%) were undergoing repeat abortions. The primary reason for the current unintended pregnancies was non-use of contraception (68%). Adolescents receiving abortions who had an increased risk of repeat abortions were those who had children (OR 2.57, 95% CI 1.80–3.67), those who resided in a middle-developed region (OR 1.81, 95% CI 1.30–2.50), those who resided in a relatively poor region (OR 2.40, 95% CI 1.78–3.23), and those who had used contraception during the 6 months preceding the survey (OR 1.38, 95% CI 1.12–1.71 for condom use). The occupation as a student was a protective factor for adolescents (OR 0.64, 95% CI 0.50–0.83). Adolescents should be offered equal access to FP to that of married women in China to reduce unintended pregnancies and repeat abortions. Correct and consistent contraception practice should be promoted.
9/11 Residential Exposures: The Impact of World Trade Center Dust on Respiratory Outcomes of Lower Manhattan Residents
Authors: Antao Vinicius , Pallos L. , Graham Shannon , Shim Youn , Sapp James , Lewis Brian , Bullard Steven , Alper Howard , Cone James , Farfel Mark , Brackbill Robert
Published: March 2019

Thousands of lower Manhattan residents sustained damage to their homes following the collapse of the Twin Towers on 11 September 2001. Respiratory outcomes have been reported in this population. We sought to describe patterns of home damage and cleaning practices in lower Manhattan and their impacts on respiratory outcomes among World Trade Center Health Registry (WTCHR) respondents. Data were derived from WTCHR Wave 1 (W1) (9/2003–11/2004) and Wave 2 (W2) (11/2006–12/2007) surveys. Outcomes of interest were respiratory symptoms (shortness of breath (SoB), wheezing, persistent chronic cough, upper respiratory symptoms (URS)) first occurring or worsening after 9/11 W1 and still present at W2 and respiratory diseases (asthma and chronic obstructive pulmonary disease (COPD)) first diagnosed after 9/11 W1 and present at W2. We performed descriptive statistics, multivariate logistic regression and geospatial analyses, controlling for demographics and other exposure variables. A total of 6447 residents were included. Mean age on 9/11 was 45.1 years (±15.1 years), 42% were male, 45% had ever smoked cigarettes, and 44% reported some or intense dust cloud exposure on 9/11. The presence of debris was associated with chronic cough (adjusted OR (aOR) = 1.56, CI: 1.12–2.17), and upper respiratory symptoms (aOR = 1.56, CI: 1.24–1.95). A heavy coating of dust was associated with increased shortness of breath (aOR = 1.65, CI: 1.24–2.18), wheezing (aOR = 1.43, CI: 1.03–1.97), and chronic cough (aOR = 1.59, CI: 1.09–2.28). Dusting or sweeping without water was the cleaning behavior associated with the largest number of respiratory outcomes, such as shortness of breath, wheezing, and URS. Lower Manhattan residents who suffered home damage following the 9/11 attacks were more likely to report respiratory symptoms and diseases compared to those who did not report home damage.
From Substance Use Disorders in Life to Autopsy Findings: A Combined Case-Record and Medico-Legal Study
Authors: Brådvik Louise , Löwenhielm Peter , Frank Arne , Berglund Mats
Published: March 2019

Objectives: Several studies have shown mortality and suicide risk in substance use disorders, and autopsy findings with respect to the used substances. However, there seems to be a gap in the knowledge about substances misused in life and at death at the within-person level. Methods: All consecutive, autopsied patients during 1993 to 1997, who had been in contact with the Addiction Centre in Malmö from 1968, were investigated (365 subjects). Drug misuse in the long-term course noted in case records was related to autopsy findings. Self-inflicted death (suicide/undetermined suicide/accidental overdose) was compared with natural death. Results: Benzodiazepine misuse was associated with a high risk of autopsy findings of the substance in suicide and death of undetermined intent. It was also associated among non-misusers, but less so. An alcohol level above 1‰ was found more often in self-inflicted death. Prescription opioids at autopsy were mainly found in self-inflicted death among non-misusers. Heroin misuse was related to overdose. Central nervous system stimulants (CNS-S) and cannabis were rarely found in self-inflicted death among previous misusers. The overlap between depression in life and antidepressants at death was low. Conclusions: Benzodiazepines and alcohol seem to disinhibit suicidal tendencies. Suicide risk among users of cannabis and CNS-S may be related to other risk factors than acute use. Implications for suicide prevention are discussed.
The Role of Vertical Transmission in the Control of Dengue Fever
Authors: Murillo David , Murillo Anarina , Lee Sunmi
Published: March 2019

In this work, a two-strain dengue model with vertical transmission in the mosquito population is considered. Although vertical transmission is often ignored in models of dengue fever, we show that effective control of an outbreak of dengue can depend on whether or not the vertical transmission is a significant mode of disease transmission. We model the effect of a control strategy aimed at reducing human-mosquito transmissions in an optimal control framework. As the likelihood of vertical transmission increases, outbreaks become more difficult and expensive to control. However, even for low levels of vertical transmission, the additional, uncontrolled, transmission from infected mosquito to eggs may undercut the effectiveness of any control function. This is of particular importance in regions where existing control policies may be effective and the endemic strain does not exhibit vertical transmission. If a novel strain that does exhibit vertical transmission invades, then existing, formerly effective, control policies may no longer be sufficient. Therefore, public health officials should pay more attention to the role of vertical transmission for more effective interventions and policy.
Gene Selection and Evolutionary Modeling Affect Phylogenomic Inference of Neuropterida Based on Transcriptome Data
Authors: Wang Yuyu , Zhou Xiaofan , Wang Liming , Liu Xingyue , Yang Ding , Rokas Antonis
Published: March 2019

Neuropterida is a super order of Holometabola that consists of the orders Megaloptera (dobsonflies, fishflies, and alderflies), Neuroptera (lacewings) and Raphidioptera (snakeflies). Several proposed higher-level relationships within Neuropterida, such as the relationships between the orders or between the families, have been extensively debated. To further understand the evolutionary history of Neuropterida, we conducted phylogenomic analyses of all 13 published transcriptomes of the neuropterid species, as well as of a new transcriptome of the fishfly species Ctenochauliodes similis of Liu and Yang, 2006 (Megaloptera: Corydalidae: Chauliodinae) that we sequenced. Our phylogenomic data matrix contained 1392 ortholog genes from 22 holometabolan species representing six families from Neuroptera, two families from Raphidioptera, and two families from Megaloptera as the ingroup taxa, and nine orders of Holometabola as outgroups. Phylogenetic reconstruction was performed using both concatenation and coalescent-based approaches under a site-homogeneous model as well as under a site-heterogeneous model. Surprisingly, analyses using the site-homogeneous model strongly supported a paraphyletic Neuroptera, with Coniopterygidae assigned as the sister group of all other Neuropterida. In contrast, analyses using the site-heterogeneous model recovered Neuroptera as monophyletic. The monophyly of Neuroptera was also recovered in concatenation and coalescent-based analyses using genes with stronger phylogenetic signals [i.e., higher average bootstrap support (ABS) values and higher relative tree certainty including all conflicting bipartitions (RTCA) values] under the site-homogeneous model. The present study illustrated how both data selection and model selection influence phylogenomic analyses of large-scale data matrices comprehensively.
Pericytes as a Source of Osteogenic Cells in Bone Fracture Healing
Authors: Supakul Sopak , Yao Kenta , Ochi Hiroki , Shimada Tomohito , Hashimoto Kyoko , Sunamura Satoko , Mabuchi Yo , Tanaka Miwa , Akazawa Chihiro , Nakamura Takuro , Okawa Atsushi , Takeda Shu , Sato Shingo
Published: March 2019

Pericytes are mesenchymal cells that surround the endothelial cells of small vessels in various organs. These cells express several markers, such as NG2, CD146, and PDGFRβ, and play an important role in the stabilization and maturation of blood vessels. It was also recently revealed that like mesenchymal stem cells (MSCs), pericytes possess multilineage differentiation capacity, especially myogenic, adipogenic, and fibrogenic differentiation capacities. Although some previous studies have reported that pericytes also have osteogenic potential, the osteogenesis of pericytes can still be further elucidated. In the present study, we established novel methods for isolating and culturing primary murine pericytes. An immortalized pericyte line was also established. Multilineage induction of the pericyte line induced osteogenesis, adipogenesis, and chondrogenesis of the cells in vitro. In addition, pericytes that were injected into the fracture site of a bone fracture mouse model contributed to callus formation. Furthermore, in vivo pericyte-lineage-tracing studies demonstrated that endogenous pericytes also differentiate into osteoblasts and osteocytes and contribute to bone fracture healing as a cellular source of osteogenic cells. Pericytes can be a promising therapeutic candidate for treating bone fractures with a delayed union or nonunion as well as bone diseases causing bone defects.
Physiological and Transcriptome Analyses of Early Leaf Senescence for ospls1 Mutant Rice (Oryza sativa L.) during the Grain-Filling Stage
Authors: Li Zhaowei , Pan Xinfeng , Guo Xiaodong , Fan Kai , Lin Wenxiong
Published: March 2019

Early leaf senescence is an important agronomic trait that affects crop yield and quality. To understand the molecular mechanism of early leaf senescence, Oryza sativa premature leaf senescence 1 (ospls1) mutant rice with a deletion of OsVHA-A and its wild type were employed in this study. The genotype-dependent differences in photosynthetic indexes, senescence-related physiological parameters, and yield characters were investigated during the grain-filling stage. Moreover, RNA sequencing (RNA-seq) was performed to determine the genotype differences in transcriptome during the grain-filling stage. Results showed that the ospls1 mutant underwent significant decreases in the maximal quantum yield of photosystem II (PSII) photochemistry (Fv/Fm), net photosynthesis rate (Pn), and soluble sugar and protein, followed by the decreases in OsVHA-A transcript and vacuolar H+-ATPase activity. Finally, yield traits were severely suppressed in the ospls1 mutant. RNA-seq results showed that 4827 differentially expressed genes (DEGs) were identified in ospls1 mutant between 0 day and 14 days, and the pathways of biosynthesis of secondary metabolites, carbon fixation in photosynthetic organisms, and photosynthesis were downregulated in the senescing leaves of ospls1 mutant during the grain-filling stage. In addition, 81 differentially expressed TFs were identified to be involved in leaf senescence. Eleven DEGs related to hormone signaling pathways were significantly enriched in auxin, cytokinins, brassinosteroids, and abscisic acid pathways, indicating that hormone signaling pathways participated in leaf senescence. Some antioxidative and carbohydrate metabolism-related genes were detected to be differentially expressed in the senescing leaves of ospls1 mutant, suggesting that these genes probably play response and regulatory roles in leaf senescence.
Closure of the Human TKFC Active Site: Comparison of the Apoenzyme and the Complexes Formed with Either Triokinase or FMN Cyclase Substrates
Authors: Rodrigues Joaquim Rui , Cameselle José Carlos , Cabezas Alicia , Ribeiro João Meireles
Published: March 2019

Human triokinase/flavin mononucleotide (FMN) cyclase (hTKFC) catalyzes the adenosine triphosphate (ATP)-dependent phosphorylation of D-glyceraldehyde and dihydroxyacetone (DHA), and the cyclizing splitting of flavin adenine dinucleotide (FAD). hTKFC structural models are dimers of identical subunits, each with two domains, K and L, with an L2-K1-K2-L1 arrangement. Two active sites lie between L2-K1 and K2-L1, where triose binds K and ATP binds L, although the resulting ATP-to-triose distance is too large (≈14 Å) for phosphoryl transfer. A 75-ns trajectory of molecular dynamics shows considerable, but transient, ATP-to-DHA approximations in the L2-K1 site (4.83 Å or 4.16 Å). To confirm the trend towards site closure, and its relationship to kinase activity, apo-hTKFC, hTKFC:2DHA:2ATP and hTKFC:2FAD models were submitted to normal mode analysis. The trajectory of hTKFC:2DHA:2ATP was extended up to 160 ns, and 120-ns trajectories of apo-hTKFC and hTKFC:2FAD were simulated. The three systems were comparatively analyzed for equal lengths (120 ns) following the principles of essential dynamics, and by estimating site closure by distance measurements. The full trajectory of hTKFC:2DHA:2ATP was searched for in-line orientations and short distances of DHA hydroxymethyl oxygens to ATP γ-phosphorus. Full site closure was reached only in hTKFC:2DHA:2ATP, where conformations compatible with an associative phosphoryl transfer occurred in L2-K1 for significant trajectory time fractions.
ETL Best Practices for Data Quality Checks in RIS Databases
Authors: Azeroual Otmane , Saake Gunter , Abuosba Mohammad
Published: March 2019

The topic of data integration from external data sources or independent IT-systems has received increasing attention recently in IT departments as well as at management level, in particular concerning data integration in federated database systems. An example of the latter are commercial research information systems (RIS), which regularly import, cleanse, transform and prepare the analysis research information of the institutions of a variety of databases. In addition, all these so-called steps must be provided in a secured quality. As several internal and external data sources are loaded for integration into the RIS, ensuring information quality is becoming increasingly challenging for the research institutions. Before the research information is transferred to a RIS, it must be checked and cleaned up. An important factor for successful or competent data integration is therefore always the data quality. The removal of data errors (such as duplicates and harmonization of the data structure, inconsistent data and outdated data, etc.) are essential tasks of data integration using extract, transform, and load (ETL) processes. Data is extracted from the source systems, transformed and loaded into the RIS. At this point conflicts between different data sources are controlled and solved, as well as data quality issues during data integration are eliminated. Against this background, our paper presents the process of data transformation in the context of RIS which gains an overview of the quality of research information in an institution’s internal and external data sources during its integration into RIS. In addition, the question of how to control and improve the quality issues during the integration process in RIS will be addressed.
Candida albicans Morphology-Dependent Host FGF-2 Response as a Potential Therapeutic Target
Authors: Vellanki Sandeep , Huh Eun Young , Saville Stephen P. , Lee Soo Chan
Published: March 2019

Angiogenesis mediated by proteins such as Fibroblast Growth Factor-2 (FGF-2) is a vital component of normal physiological processes and has also been implicated in contributing to the disease state associated with various microbial infections. Previous studies by our group and others have shown that Candida albicans, a common agent of candidiasis, induces FGF-2 secretion in vitro and angiogenesis in brains and kidneys during systemic infections. However, the underlying mechanism(s) via which the fungus increases FGF-2 production and the role(s) that FGF-2/angiogenesis plays in C. albicans disease remain unknown. Here we show, for the first time, that C. albicans hyphae (and not yeast cells) increase the FGF-2 response in human endothelial cells. Moreover, Candidalysin, a toxin secreted exclusively by C. albicans in the hyphal state, is required to induce this response. Our in vivo studies show that in the systemic C. albicans infection model, mice treated with FGF-2 exhibit significantly higher mortality rates when compared to untreated mice not given the angiogenic growth factor. Even treatment with fluconazole could not fully rescue infected animals that were administered FGF-2. Our data suggest that the increase of FGF-2 production/angiogenesis induced by Candidalysin contributes to the pathogenicity of C. albicans.
Optical Properties of Submillimeter Silver Nanowires Synthesized Using the Hydrothermal Method
Authors: Ćwik Michał , Buczyńska Dorota , Sulowska Karolina , Roźniecka Ewa , Mackowski Sebastian , Niedziółka-Jönsson Joanna
Published: March 2019

We report on the synthesis of long silver nanowires using the hydrothermal method, with H2O2 as the reducing agent. Our approach yields nanowires with an average diameter and length of about 100 nm and 160 µm, respectively, reaching the maximum length of 800 µm. Scanning electron microscopy (SEM) measurements revealed the presence of a thick, inhomogeneous poly(vinylpyrrolidone) (PVP) layer covering the nanowires, which with time becomes much more uniform, leading to well-defined extinction peaks in the ultraviolet-visible (UV-Vis) spectra. This change in morphology is evidenced also by the fluorescence enhancement behavior probed using protein complexes. Wide-field and confocal fluorescence microscopy measurements demonstrate strong, 10-fold enhancement of the protein emission intensity, accompanied by a reduction of the fluorescence decay time. In addition, for the aged, one-month-old nanowires, the uniformity of the intensity profile along them was substantially improved as compared with the as-synthesized ones. The results point towards the importance of the morphology of plasmonically active silver nanowires when considering their application in enhancing optical properties or achieving energy propagation over submillimeter distances.
Effects of Ions-Releasing Restorative Materials on the Dentine Bonding Longevity of Modern Universal Adhesives after Load-Cycle and Prolonged Artificial Saliva Aging
Authors: Sauro Salvatore , Makeeva Irina , Faus-Matoses Vicente , Foschi Federico , Giovarruscio Massimo , Maciel Pires Paula , Martins Moura Maria Elisa , Almeida Neves Aline , Faus-Llácer Vicente
Published: March 2019

This study aimed at evaluating the microtensile bond strength (MTBS) and fractographic features of dentine-bonded specimens created using universal adhesives applied in etch-and-rinse (ER) or self-etching (SE) mode in combination with modern ion-releasing resin-modified glass-ionomer cement (RMGIC)-based materials after load cycling and artificial saliva aging. Two universal adhesives (FTB: Futurabond M+, VOCO, Germany; SCU: Scotchbond Universal, 3M Oral Care, USA) were used. Composite build-ups were made with conventional nano-filled composite (AURA, SDI, Australia), conventional resin-modified glass ionomer cement (Ionolux VOCO, Germany), or a (RMGIC)-based composite (ACTIVA, Pulpdent, USA). The specimens were divided in three groups and immersed in deionized water for 24 h, load-cycled (350,000 cycles; 3 Hz; 70 N), or load-cycled and cut into matchsticks and finally immersed for 8 months in artificial saliva (AS). The specimens were cut into matchsticks and tested for microtensile bond strength. The results were analyzed statistically using three-way ANOVA and Fisher’s LSD post hoc test (p < 0.05). Fractographic analysis was performed through stereomicroscope and FE-SEM. FTB showed no significant drop in bond strength after aging. Unlike the conventional composite, the two RMGIC-based materials caused no bond strength reduction in SCU after load-cycle aging and after prolonged aging (8 months). The SEM fractographic analysis showed severe degradation, especially with composite applied on dentine bonded with SCU in ER mode; such degradation was less evident with the two GIC-based materials. The dentine-bond longevity may be influenced by the composition rather than the mode of application (ER vs. SE) of the universal adhesives. Moreover, the choice of the restorative material may play an important role on the longevity of the finalrestoration. Indeed, bioactive GIC-based materials may contribute to maintain the bonding performance of simplified universal adhesives over time, especially when these bonding systems are applied in ER mode.
Synthesis and Catalytic Properties of Modified Electrodes by Pulsed Electrodeposition of Pt/PANI Nanocomposite
Authors: Ourari Ali , Zerdoumi Ridha , Ruiz-Rosas Ramiro , Morallon Emilia
Published: March 2019

In this study, the modification of glassy carbon electrodes by potentiostatic pulsed deposition of platinum nanoparticles and potentiostatic pulsed polymerization of polyaniline nanofibers was investigated. During the preparation of the nano-composite materials, the control of the potentiostatic pulsed deposition and potentiostatic pulsed polymerization parameters, such as pulse potential, pulse width time, duty cycle, and platinum precursor concentration allowed the optimization of the size, shape, and distribution of the deposited Pt nanoparticles. It is noteworthy that the polymerization method, cyclic voltammetry method, or potentiostatic pulsed polymerization method show an important effect in the morphology of the deposited polyaniline (PANI) film. The obtained modified electrodes, with highly uniform and well dispersed platinum nanoparticles, exhibit good electrocatalytic properties towards methanol oxidation.
Experimental and Modeling Study of the Evolution of Mechanical Properties of PAN-Based Carbon Fibers at Elevated Temperatures
Authors: Li Chenggao , Xian Guijun
Published: March 2019

In the present article, the degradation of the tensile properties of polyacrylonitrile (PAN)-based carbon fibers at elevated temperatures in air was studied experimentally and modeled. The tensile properties, mass loss, surface morphology, and elements and functional groups of carbon fibers were characterized. It can be concluded that the tensile strength and modulus of the carbon fibers decreased remarkably when the exposure temperature exceeded 500 °C. Oxidation at elevated temperatures etched the carbon layer from the skin to the core of the carbon fibers, leading to mass loss. According to the rule of mixtures, an exponential decay model was put forward to describe the degradation behavior of tensile modulus exposed to different temperatures and times. The thickness of the outer layer (Touter) of carbon fibers was obtained to be 0.818 μm. The ultimate exposure temperature was predicted to be 699.4 °C for 30 min, and the ultimate exposure time was 13.2 h at 500 °C. Furthermore, the time–temperature equivalence equation of tensile modulus was deduced. Through the introduction of the normalized oxidation degree, a degradation model of the tensile modulus at any exposure temperature (~800 °C) and time (~800 min) was also proposed. From the elastic mechanics theory for anisotropic solids, the degradation model of tensile strength exposed to elevated temperature was confirmed. It can be observed that the proposed model had good agreement with the experimental results.
Study of Catalytic Combustion of Chlorobenzene and Temperature Programmed Reactions over CrCeOx/AlFe Pillared Clay Catalysts
Authors: Qiu Yingnan , Ye Na , Situ Danna , Zuo Shufeng , Wang Xianqin
Published: March 2019

In this study, both AlFe composite pillaring agents and AlFe pillared clays (AlFe-PILC) were synthesized via a facile process developed by our group, after which mixed Cr and Ce precursors were impregnated on AlFe-PILC. Catalytic combustion of organic pollutant chlorobenzene (CB) on CrCe/AlFe-PILC catalysts were systematically studied. AlFe-PILC displayed very high thermal stability and large BET surface area (SBET). After 4 h of calcination at 550 °C, the basal spacing (d001) and SBET of AlFe-PILC was still maintained at 1.91 nm and 318 m2/g, respectively. Large SBET and d001-value, along with the strong interaction between the carrier and active components, improved the adsorption/desorption of CB and O2. When the desorption temperatures of CB and O2 got closer to the CB combustion temperature, the CB conversion could be increased to a higher level. CB combustion on CrCe/AlFe-PILC catalyst was determined using a Langmuir–Hinshelwood mechanism. Adsorption/desorption/oxidation properties were critical to design highly efficient catalysts for CB degradation. Besides, CrCe/AlFe-PILC also displayed good durability for CB combustion, whether in a humid environment or in the presence of volatile organic compound (VOC), making the catalyst an excellent material for eliminating chlorinated VOCs.
Size-Dependent Free Vibration and Buckling of Three-Dimensional Graphene Foam Microshells Based on Modified Couple Stress Theory
Authors: Liu Yunfei , Wang Yanqing
Published: March 2019

In this research, the vibration and buckling of three-dimensional graphene foam (3D-GrF) microshells are investigated for the first time. In the microshells, three-dimensional graphene foams can distribute uniformly or non-uniformly through the thickness direction. Based on Love’s thin shell theory and the modified couple stress theory (MCST), size-dependent governing equations and corresponding boundary conditions are established through Hamilton’s principle. Then, vibration and axial buckling of 3D-GrF microshells are analyzed by employing the Navier method and Galerkin method. Results show that the graphene foam distribution type, size effect, the foam coefficient, the radius-to-thickness ratio, and the length-to-radius ratio play important roles in the mechanical characteristics of 3D-GrF microshells.
Osteoclastogenesis Behavior of Zirconia for Dental Implant
Authors: Ganbold Boldbayar , Kim Seong-Kyun , Heo Seong-Joo , Koak Jai-Young , Lee Zang Hee , Cho Jaejin
Published: March 2019

Zirconia is worth studying as an alternative to dental titanium implants to overcome the disadvantages of titanium. This study investigated the surface characteristics of the zirconia implant material and osteoclastogenesis responses on the surface compared with titanium. Yttrium oxide-stabilized 5% tetragonal zirconia polycrystalline specimens were manufactured, and osteoclast-precursor cells were cultured and differentiated into osteoclasts on the specimens. Surface shape, roughness, and chemical composition were evaluated. After culturing, cell morphologies and differentiation capacity were analyzed using tartrate-resistant acid phosphatase activity (TRACP). mRNA of two critical transcription factors, nuclear factor of activated T-cells 1 (NFATc1) and c-Fos were measured, and protein levels of NFATc1 and c-Fos were investigated. The zirconia specimens had rhomboid-like shapes with smooth surfaces and exhibited no difference in surface roughness compared to the titanium specimens. Morphologies of differentiated osteoclasts on both materials were similar. TRACP activity on the zirconia showed comparable results to that on the titanium. The mRNA value of NFATc1 on the zirconia was higher than that on the titanium at day four. The protein level of c-Fos was expressed thicker on the zirconia when compared to the titanium at day two. The results of this study suggest that zirconia material provides adequate osteoclastogenesis behaviors for dental implant use.
A Fast Beamforming Method to Localize an Acoustic Emission Source under Unknown Wave Speed
Authors: Tai Junfei , He Tian , Pan Qiang , Zhang Dayi , Wang Xiaoran
Published: March 2019

The beamforming method is capable of localizing the acoustic emission source in a large-scale structure but its accuracy relies strongly on the assumed propagation speed and it is quite time consuming to apply in online monitoring. This paper proposes a fast beamforming method to localize an acoustic emission source in a thin-walled structure with unknown wave speed. Firstly, the Bartlett beamforming method (BBM) is introduced into broadband Lamb wave signal processing to develop an L-shape array-based damage source localization method for a thin-walled structure. Secondly, the fast Bartlett beamforming method (FBBM) is proposed based on the characteristics of BBM. Finally, the pencil-lead break test is carried out to validate the proposed method. The test results show that the FBBM can accurately localize the damage source by any given probable wave speed much more rapidly than traditional delay-and-sum beamforming.
Undoped and Eu3+ Doped Magnesium-Aluminium Layered Double Hydroxides: Peculiarities of Intercalation of Organic Anions and Investigation of Luminescence Properties
Authors: Smalenskaite Aurelija , Pavasaryte Lina , Yang Thomas C. K. , Kareiva Aivaras
Published: March 2019

The Mg3/Al and Mg3/Al0.99Eu0.01 layered double hydroxides (LDHs) were fabricated using a sol-gel chemistry approach and intercalated with different anions through ion exchange procedure. The influence of the origin of organic anion (oxalate, laurate, malonate, succinate, tartrate, benzoate, 1,3,5-benzentricarboxylate (BTC), 4-methylbenzoate (MB), 4-dimethylaminobenzoate (DMB) and 4-biphenylacetonate (BPhAc)) on the evolution of the chemical composition of the inorganic-organic LDHs system has been investigated. The obtained results indicated that the type and arrangement of organic guests between layers of the LDHs influence Eu3+ luminescence in the synthesized different hybrid inorganic–organic matrixes. For the characterization of synthesis products X-ray diffraction (XRD) analysis, infrared (FTIR) spectroscopy, fluorescence spectroscopy (FLS), and scanning electron microscopy (SEM), were used.
Plastic Deformation Behavior of Bi-Crystal Magnesium Nanopillars with a {1012} Twin Boundary under Compression: Molecular Dynamics Simulations
Authors: Yang Xiaoyue , Xu Shuang , Chi Qingjia
Published: March 2019

In this study, molecular dynamics simulations were performed to study the uniaxial compression deformation of bi-crystal magnesium nanopillars with a { 10 1 ¯ 2 } twin boundary (TB). The generation and evolution process of internal defects of magnesium nanopillars were analyzed in detail. Simulation results showed that the initial deformation mechanism was mainly caused by the migration of the twin boundary, and the transformation of TB into (basal/prismatic) B/P interface was observed. After that, basal slip as well as pyramidal slip nucleated during the plastic deformation process. Moreover, a competition mechanism between twin boundary migration and basal slip was found. Basal slip can inhibit the migration of the twin boundary, and { 10 1 ¯ 1 } ⟨ 10 1 ¯ 2 ⟩ twins appear at a certain high strain level ( ε = 0.104). In addition, Schmid factor (SF) analysis was conducted to understand the activations of deformation modes.
Preparation and Characteristics of Ethylene Bis(Stearamide)-Based Graphene-Modified Asphalt
Authors: Zhang Xia , He Jun-Xi , Huang Gang , Zhou Chao , Feng Man-Man , Li Yan
Published: March 2019

In this study, graphene-modified asphalt (GMA) was prepared from SK-70# matrix asphalt and ethylene bis(stearamide) (EBS). Based on the uniform design method, a model was created using Data Processing System (DPS) software and First Optimization (1stOpt) software using the graphene mixing amount, EBS mixing amount, shear rate, shear time, and shear temperature as factors and using the asphalt penetration, softening point, force ductility, SHRP-PG test, and multistress creep recovery data as indices. Calculations and analysis showed that the optimal composition and preparation parameters of GMA are as follows: the graphene proportion is 20‰, the EBS proportion is 1%, the shear rate is 6000 r.p.m., the shear time is 180 min, and the shear temperature is 140 °C. The prepared GMA had a significantly improved softening point, low-temperature fracture energy, antirutting factor, and creep recovery rate, indicating that adding graphene can improve the high- and low-temperature performance of asphalt. The prepared GMA was characterized by X-ray diffraction (XRD). The dispersibility of graphene in asphalt was evaluated by fluorescence microscopy and Image-Pro Plus imaging software. The results show that graphene can exist in asphalt in a stable form, which increases the loose-layered structure of stacked asphalt or gum. The intense adsorption effect of graphene strengthens the ordered structure of asphalt. However, due to its dispersibility characteristics, some graphene exists in asphalt in clustered form. When the graphene-to-dispersant ratio approaches the optimal value, the dispersant changes the form of graphene in asphalt from irregular clusters to regular clusters and from large, distinct clusters to small, indistinct clusters. When dispersant cannot uniformly disperse graphene in asphalt, graphene clusters primarily form medium-sized grains.
The Prouhet Tarry Escott Problem: A Review
Authors: Raghavendran Srikanth , Narayanan Veena
Published: March 2019

This paper presents a review of the Prouhet Tarry Escott problem. The solutions of the Prouhet Tarry Escott problem are significant because of its numerous applications. Available literature about the present topic has been critically examined. The ideal and non-ideal symmetric solutions of the problem are pointed out. The present work also aims to familiarize one with the different existing methods of obtaining the solutions of the Tarry Escott problem. Difficulties and possible future research directions are addressed. This review contributes a clear picture of the Prouhet Tarry Escott problem.
A Mathematical Model for Intimate Partner Violence
Authors: Delgadillo-Aleman Sandra , Ku-Carrillo Roberto , Perez-Amezcua Brenda , Chen-Charpentier Benito
Published: March 2019

In the context of mathematical models applied to social sciences, we present and analyze a model based on differential equations for the intimate partner violence (IPV). Such a model describes the dynamics of a heterosexual romantic couple in which the man perpetrates violence against the woman. We focus on incorporating different key factors reported in the literature as causal or motivational factors to perpetrate IPV. Among the main factors included are the failures in self-regulation, the man’s need to control the woman, the social pressure on the woman to remain married, and empowerment programs. Another aspect that we include is periodic alcohol consumption for the man. The discussion of the model includes a stability analysis of its equilibrium points and the asymptotic behavior of its solutions. Also, the interpretation of results is presented in terms of IPV phenomenon. Finally, a brief review is given on different scales to quantify human behavioral traits and numerical simulations for some IPV scenarios.
Discovery of Stealthin Derivatives and Implication of the Amidotransferase FlsN3 in the Biosynthesis of Nitrogen-Containing Fluostatins
Authors: Huang Chunshuai , Yang Chunfang , Fang Zhuangjie , Zhang Liping , Zhang Wenjun , Zhu Yiguang , Zhang Changsheng
Published: March 2019

Diazobenzofluorene-containing atypical angucyclines exhibit promising biological activities. Here we report the inactivation of an amidotransferase-encoding gene flsN3 in Micromonospora rosaria SCSIO N160, a producer of fluostatins. Bioinformatics analysis indicated that FlsN3 was involved in the diazo formation. Chemical investigation of the flsN3-inactivation mutant resulted in the isolation of a variety of angucycline aromatic polyketides, including four racemic aminobenzo[b]fluorenes stealthins D–G (9–12) harboring a stealthin C-like core skeleton with an acetone or butanone-like side chain. Their structures were elucidated on the basis of nuclear magnetic resonance (NMR) spectroscopic data and X-ray diffraction analysis. A plausible mechanism for the formation of stealthins D–G (9–12) was proposed. These results suggested a functional role of FlsN3 in the formation/modification of N–N bond-containing fluostatins.