bluuebunny/crossref_metadata_2025 huggingface dataset:
Toxina Botulínica para Indicações Cosméticas: uma visão geral
Authors: MAGANHIN LUQUETTI CAMILLA , Daniel Zanoni Rodrigo , Barreira Alves Neto Luís , Parreira de Assis Gabriela , Buss Heidemann Débora , Brasileiro Diniz Beatriz , Melo Souza de Farias Tassila , Oliveira Benine Sarah , Mendes Santos João Marcos , Nery Diniz Pessanha Débora , Siqueira Nunes Mirele , Cristina Maganhin Carla
Published: August 2024

Introdução: A toxina botulínica é derivada de neurotoxinas produzidas pela Clostridium botulinum. Com capacidade de inibir a neurotransmissão entre nervos periféricos e tecido muscular, é eficaz em preocupações estéticas ao enfraquecer a contração muscular. Embora a aprovação da Food and Drug Administration (FDA) para o uso cosmético seja limitada a linhas glabelares, cantais laterais e da testa, é usada para outras indicações. Conhecimento profundo da anatomia e função muscular é crucial na administração eficaz e segura. A inadequação pode resultar em desfiguração e déficits funcionais persistentes por meses. Sua dosagem não é intercambiável entre diferentes formulações. Objetivo: discutir indicações cosméticas da toxina em locais específicos. Metodologia:Revisão de literatura integrativa a partir de bases da Scielo, da PubMed e da BVS, de março a maio de 2024, com descritores “Botulinum toxin”, “cosmetic indications”, “treatment” e “specific sites”, cadastrados no DeCS/MeSH e operador “AND”. Incluíram-se artigos de 2019-2024 (total 51), com exclusão de outros critérios e escolha de 05 artigos na íntegra. Resultados e Discussão:Candidatos apropriados para injeção são aqueles em que tais preocupações estéticas podem ser aliviadas pelo enfraquecimento muscular local e sem contraindicações; geralmente idosos não se beneficiam pela perda da elasticidade da pele. Há de se garantir que a colocação anatômica das injeções esteja correta e que as doses sejam apropriadas com base no local de tratamento e nas características específicas do paciente. Os locais nos músculos que deprimem a sobrancelha resultam em melhorias nas rítides glabelares, sendo que homens precisam de doses maiores devido à maior massa muscular nessa área. Todas as injeções devem ser colocadas acima da borda supraorbital para reduzir o risco de ptose da pálpebra superior. O tratamento bem-sucedido de rugas horizontais da testa requer tratamento simultâneo do músculo frontal e dos depressores da sobrancelha. Injeções colocadas muito baixas no músculo frontal podem resultar em ptose da sobrancelha. As rugas cantais laterais (pés de galinha) podem ser tratadas com sucesso com múltiplas injeções no músculo orbicular lateral, com musculatura facial em repouso e injeções laterais. Além do tratamento facial, a toxina botulínica pode ser usada para melhorar a aparência do pescoço. Pacientes com bandas platismais ou linhas horizontais do pescoço podem se beneficiar. Conclusão: Há necessidade de profundo conhecimento da anatomia facial e das relações funcionais entre músculos do rosto e do pescoço para uso com segurança da toxina botulínica. Só assim há enfraquecimento seletivo de músculos específicos, com resultados estéticos favoráveis.
Visão geral e aspectos clínicos do glaucoma em bebês e crianças
Authors: MAGANHIN LUQUETTI CAMILLA , Laperuta Pauletti Carolina , Ferray Soares Thays , Abensur Fróes Ramos Fernanda , Caroline Zanatta Pedon Isabel , Fabiano Zamora Paulo Henrique , Nascimento Santos Luíza , Rocha de Oliveira Anna Isabel , Sousa Grego Júlia , Pomarico de Oliveira Pedro , Cristina Maganhin Carla , Assunção de Andrade Lima Júnior Elson , ALMEIDA ISIS MARCONDES SODRÉ DE
Published: August 2024

Introdução: O glaucoma representa um grupo heterogêneo de doenças oculares com neuropatia óptica progressiva, manifestada pela escavação do disco óptico e, geralmente, associada ao aumento da pressão intraocular (PIO). Pode levar a danos no nervo óptico e consequente perda visual. A perda da visão periférica ocorre primeiro, mas se o glaucoma não for tratado, pode levar à perda da visão central e à cegueira completa. Em bebês e crianças pequenas, podem ocorrer danos adicionais ao sistema visual, incluindo erro refrativo grande e potencialmente assimétrico, edema ou cicatrizes da córnea, astigmatismo, estrabismo e ambliopia. O diagnóstico e o encaminhamento precoces são cruciais para garantir o resultado visual ideal. Objetivo: compreender a visão geral do glaucoma em bebês e crianças. Metodologia: Revisão de literatura a partir de bases da Scielo, da PubMed e da BVS, de março a maio de 2024, com descritores “glaucoma”, “management”, “babies”, e “children”, cadastrados no DeCS/MeSH e operador “AND”. Incluíram-se artigos de 2019-2024 (total 181), com exclusão de outros critérios e escolha de 05 artigos na íntegra. Resultados e Discussão: O glaucoma pode ser classificado quanto ao ângulo da câmara anterior (aberto/fechado) e primário/secundário. O de ângulo aberto é o mais comum em crianças e adultos, com perda progressiva do campo visual periférico seguida de perda de campo central em um padrão típico. Quando primário, há malformação angular isolada (trabeculodisgênese), sendo raro na infância e com início nos primeiros anos de vida. A idade em que os sintomas aparecem pela primeira vez provavelmente está relacionada à gravidade da disgênese angular. Se juvenil, aparece após 4-5 anos de idade. Geralmente são assintomáticos e o dano ao nervo óptico é oculto. O diagnóstico é dado pelo dano ao nervo óptico no exame do fundo de olho tipicamente na presença de PIO elevada e déficit de campo visual. Na maioria dos casos, há histórico familiar positivo. A intervenção cirúrgica é base terapêutica e medicamentos são adjuvantes. A frequência de acompanhamento depende da gravidade. Quando secundário, é adquirido ou relacionado à anormalidade ocular subjacente, em qualquer idade e pode estar presente no nascimento (ex: tumores, trauma, glicocorticoides, retinotipatia da prematuridade). O diagnóstico é confirmado com exame de fundo, tonometria e campimetria. Conclusão: Glaucoma é a segunda principal causa de cegueira no mundo. A neuropatia óptica nem sempre apresenta aumento da pressão intraocular, o que pode atrasar o diagnóstico. Faz-se importante o reconhecimento e diagnóstico precoce, bem como acompanhamento com oftalmologista na infância.
Whose Umntu Anyway? Ubuntu in Relation to Gender and Human Dignity: Missiological Implications
Authors: Penxa-Matholeni Nobuntu
Published: August 2024

The concept of ubuntu has been widely explored across various academic disciplines, yet it has also been subject to misuse and commercial exploitation. It has been appropriated as the name of an open-source operating system, a soft-drink brand, and various education initiatives, among other things. Furthermore, ubuntu has been employed to justify practices that exploit hospitality and perpetuate gender binaries. This paper contends that, considering these contexts, the concept has been overcooked and has lost its taste.
2. Jan Smuts and the World Counter‑Revolution 1917-1923
Authors: Hyslop Jonathan
Published: August 2024

At 7.20 p.m. on Tuesday 1 April 1919, a train steamed out of Paris’s Gare de l’Est. On board was a delegation dispatched from the Supreme Council of the victorious powers of World War I. The mission was led by Jan Christiaan Smuts, Minister of Defence and Deputy Prime Minister of the Union of South Africa and a member, since June 1917, of the Imperial War Cabinet. Smuts's task was to negotiate with the revolutionary government of Béla Kun, which had seized power in Hungary in the aftermath of the collapse of the Austro-Hungarian Empire, and the subsequent failure of the liberal government of Count Mihály Károlyi. The Council was considering how to handle the military confrontation that had been shaping up between the Romanian and Hungarian forces over disputed border territories. It had been toying with sending a Romanian army, under the command of France’s General Charles Mangin, to crush the revolutionaries. But the Council would first allow the South African to exercise the powers of intellect and persuasion with which he was credited by his admirers (Nicolson, 1933: Hancock & van der Poel, 1966b:105-118).
Exploring the Foundations of Quantum Mechanics: Recent Developments and Open Questions
Authors: Kumar Arun
Published: August 2024

The foundations of quantum mechanics have been a subject of intense investigation and debate since the theory's inception. Recent developments in quantum technologies and theoretical frameworks have shed new light on foundational issues and raised intriguing questions about the nature of reality at the quantum level. recent advancements in our understanding of the foundational principles of quantum mechanics and discuss unresolved questions that continue to challenge our conceptual framework. Topics of interest include the measurement problem, quantum entanglement, the role of contextuality and nonlocality, interpretations of quantum theory, and the quest for a unified theory of quantum gravity. findings and ongoing debates in the field, we aim to provide a comprehensive overview of the current state of research in the foundations of quantum mechanics and stimulate further discussion and inquiry into these fundamental questions.
IbM PELATIHAN PEMANFAATAN E-COMMERCE SEBAGAI MEDIA PEMASARAN GLOBAL UNTUK PENINGKATAN PENJUALAN PRODUK KELOM GEULIS (Studi Kasus: UKM kelom geulis Tamansari Tasikmalaya)
Authors: Rachman Andi Nur , Sidik Ramdani Cecep Muhamad
Published: August 2024

Kegiatan pengabdian pada masyarakat adalah penguatan daya beli produk Kelom Geulis melalui implementasi E-Commerce berbasis Web dan pendampingan penggunaannya menggunakan teknologi informasi pada UKM pengrajin kelom geulis Regga dan Salwa di kecamatan Tamansari Tasikmalaya, sehingga meningkatkan kemandirian ekonomi melalui usaha kerajinan kelom geulis sebagai produk khas daerah Tasikmalaya, khususnya pada keterampilan pemanfaatan teknologi informasi dan internet dalam kegiatan marketing secara global. Permasalahan yang diangkat adalah peningkatan pelayanan penjualan, pemasaran, pemesanan produk dari konsumen dan peningkatan manajemen (organizer) pemesanan produk dengan implementasi teknologi informasi. Solusi yang ditawarkan adalah pembuatan aplikasi e-Commerce dibuat berbasis teknologi web dan mobile web. Penerapan aplikasi kepada mitra melalui kegiatan transfer knowledge melalui pelatihan dan pendampingan mitra dalam menggunakan aplikasi e-commerce. Pelaksanaan kegiatan dengan metode Rational Unified Process (RUP) terdiri dari Inception, Elaboration, Construction dan terakhir transition. Detail dari fase RUP diantaranya Focus Group Discussion (FGD) untuk menjalin keterbukaan, kepercayaan, dan memahami persepsi, sikap, serta pengalaman dan persoalan yang dimiliki pengrajin (Salwa dan Regga Kelom Geulis) dalam melakukan pemasaran melalui internet, pembuatan aplikasi sesuai hasil FGD, kemudian dilanjutkan pada pendampingan yaitu penyuluhan dan pelatihan penggunaan E-Commerce sebagai yang meliputi desain iklan, perawatan domain, upload konten iklan di aplikasi E-Commerce, manajemen pemasaran, organizer pesanan pelanggan melalui e-Commerce, hingga perawatan website.

Kata Kunci : e-Commerce, Kelom Geulis, FGD, pelatihan.
PELATIHAN PENERAPAN SISTEM LAYANAN ADMINISTRASI PENDUDUK DESA BERBASIS TEKNOLOGI INFORMASI
Authors: Rianto Rianto , Mubarok Husni , Aradea Aradea
Published: August 2024

Tugas dari aparatur desa adalah bagaimana memberikan pelayanan terhadap masyarakat dengan pelayanan maksimal. Salah satu tugas pelayanan yang diberikan adalah pembuatan surat keterangan yang dibutuhkan oleh masyarakat, diantaranya pembuatan surat keterangan tidak mampu, keterangan domisili, perizinan, kelahiran, dan lain-lain. Beberapa kendala yang dihadapi dalam pelayanan tersebut diantaranya masih menggunakan proses manual serta sebagian menggunakan aplikasi microsoft office. Proses tersebut memiliki kelemahan format surat berbeda-beda dan belum adanya penerapan basis data kependudukan yang dapat menyebabkan pencatatan yang tidak akurat. Permasalahan lain ditambah dengan kurangnya kemampuan penggunaan IT aparatur desa sehingga menyebabkan pelayaannya tidak optimal. Dengan permasalahan tersebut maka dibutuhkan suatu pelatihan penggunaan dan penerapan IT bagi aparatur desa dalam pelayanan administrasi desa khususnya dalam pembuatan surat keterangan. Manfaat dari pelatihan tersebut diharapkan dapat membantu aparatur desa dalam proses pelayanan terhadap masyarakat terutama pencatatan data surat menyurat sehingga pelayanan administrasi yang dirasakan masyarakat menjadi lebih baik. Metode pelatihan yang dilakukan meliputi pelatihan penggunaan aplikasi surat dan pengelolaan data kependudukan sesuai format yang berlaku.Â Hasil aplikasi memberikan kemudahan kepada aparatur desa dalam upaya optimalisasi layanan terhadap masyarakat.
İngiltere Premier Lig Futbol Kulüplerinin Sosyal Değişim Uygulamalarının Spor ve Sosyal Hizmet Perspektifinde İncelenmesi
Authors: Arı Furkan , Boduroğlu Gökhan
Published: August 2024

Sporun en çok takip edilen ve sosyal değişim gücü en fazla olan branşı futbolun üçüncü sektörün en önemli aktörlerinden biri olduğu bilinmektedir. Bu bağlamda futbol kulüpleri de sivil oluşumları ile sosyal risklere karşı spor özelinde futbolun gücünü kullanarak çeşitli sosyal hizmet müdahaleleri gerçekleştirmektedir. Bu çalışma, İngiltere Premier Lig futbol kulüpleri bünyesinde bulunan vakıfların yürütmüş olduğu sosyal hizmet uygulamalarının incelenmesine odaklanmaktadır. Çalışmada Premier Lig futbol kulüplerinin hangi sosyal hizmet uygulamalarını gerçekleştirdikleri incelenmiş olup bu uygulamalar MAXQDA programı aracılığıyla detaylı bir şekilde analiz edilmiştir. Bu analizler sonucunda kulüplerin bünyelerinde bulunan vakıfların futbolun da gücünü kullanarak daha çok sağlık hizmetleri, eğitim, istihdam, sosyal içerme ve sosyal refah alanlarına yönelik çalışmalar yaptığına dair bulgulara ulaşılmıştır. Çalışmadan elde edilen bulgular, futbol kulüplerinin sivil oluşumlarının sporun gücünü kullandıklarında etkili ve sürdürülebilir sosyal hizmet müdahalesi gerçekleştirebileceğini göstermektedir. Bu çalışmanın amacı, İngiltere’deki benzer uygulamalardan yola çıkılarak Türk futbol kulüplerinin de sosyal hizmet alanında daha çok aktif olmaları gerektiğine yönelik farkındalık sağlamaktır.
Anticancer peptides as novel immunomodulatory therapeutic candidates for cancer treatment
Authors: Sood Apurva , Jothiswaran V.V. , Singh Amrita , Sharma Anuradha
Published: August 2024

Cancer remains a concern after years of research in this field. Conventional therapies such as chemotherapy, radiation, and surgery are available for cancer treatment, but they are characterized by various side effects. There are several immunological challenges that make it difficult for the immune system and conventional therapies to treat cancer. Some of these challenges include heterogeneity, resistance to medicines, and cancer relapse. Even advanced treatments like immune checkpoint inhibitors (ICIs), which revolutionized cancer treatment, have associated toxicity and resistance further necessitate the exploration of alternative therapies. Anticancer peptides (ACPs) offer promising potential as cancer-fighting agents and address challenges such as treatment resistance, tumor heterogeneity, and metastasis. Although these peptides exist as components of the defense system in various plants, animals, fungi, etc., but can also be created synthetically and used as a new treatment measure. These peptides possess properties that make them appealing for cancer therapy, such as apoptosis induction, inhibition of angiogenesis, and cell membrane breakdown with low toxicity. Their capacity to specifically target cancer cells selectively holds promise for enhancing treatment environments as well as improving patients’ quality of life. This review provides detailed insights into the different prospects of ACPs, including their characterization, use as immunomodulatory agents in cancer treatment, and their mechanistic details after addressing various immunological challenges in existing cancer treatment strategies. In conclusion, ACPs have promising potential as novel cancer therapeutics due to their target specificity and fewer side effects than conventional therapies.
Armenian-Azerbaijani relations in the Context of recognition of Azerbaijan's sovereignty over Nagorno-Karabakh
Authors:   North Ossetian State University named after K.L. Khetagurov, Koibaev B. G. ,   North-Caucasus Mining and Metallurgical Institute (State Technological University), Revazov V. Ch. ,   North-Caucasus Mining and Metallurgical Institute (State Technological University)
Published: August 2024

The problem of Nagorno-Karabakh's ownership remains relevant when considering Armenian-Azerbaijani relations, despite the fact that Armenia has actually recognized Azerbaijan's sovereignty over it. In this regard, the article, based on the analysis of documents and statements of political figures from countries interested in resolving pressing issues of regional security in the South Caucasus, examines the modern policies of Russia, Armenia, Azerbaijan, Turkey and other geopolitical players in the region, in particular their position regarding problems of Nagorno-Karabakh within the framework of the Armenian-Azerbaijani confrontation, as the most important component of the entire system of international relations in the South Caucasus.
The Neural network development of food formulations and evaluation of the quality characteristics of finished products
Authors:   Belgorod University of Cooperation, Economics and Law, Stavropol Institute of Cooperation (branch), Sadovoy V. V. , Shchedrina T. V. ,   North-Caucasus Federal University, Pyatigorsk Institute (branch), Khamitsaeva А. S. ,   Gorsky State Agrarian University, Trubina I. А. ,   Stavropol State Agrarian University
Published: August 2024

Using statistical methods of visualization of experimental data, the use of artificial intelligence for the development of optimal food formulations in terms of qualitative characteristics is justified. Using the example of sausage products, a method for identifying the prescription composition of food products has been developed for comparison with the indicators of technical documentation. The assessment of the adequacy of the chemical and amino acid compositions of the formulations of the technical documentation confirmed the effectiveness of the developed methodology.
Leadership in the Family from the Perspective of Modern Family Jurisprudence
Authors: M. Waritsul Firdaus. F  , M. Shofwan Taufiq
Published: August 2024

The evolving view in society regarding the status and role of women is still divided into two opposite poles. On the one hand, it is generally argued that women should be in the home, serve their husbands and only have a domestic role. Meanwhile, on the other hand, there is also a growing notion that women should be free in accordance with their right to freedom. In this study, the authors used a type of library research. The primary data source in this study is progressive Muslim fiqh. The secondary data sources are books that support the author to supplement from the primary data source. The result of this study is Q.S. An-Nisa: 34 it is often mistaken that all men are female leaders, including in the family. The word ar-rijal in question is a man in particular, that is, a certain husband because of the consideration of the continuation of the verse because they provide for part of their property. So here is a continuation of the verse God has exaggerated some of them over others, which shows that the man in question is the one who has advantages in various respects from the female
Limitation Of Authority Between Central And Local Governments In The Oil And Gas Business
Authors: Wulan Dewi Nawang , Rusydi  , Ahmad Munir  , Ahmad Taufiq Rifaldi
Published: August 2024

The oil and gas revenue-sharing system for several regions has conflicting norms for regulating authority between the central government and regional governments in the oil and gas revenue-sharing system for several regional governments. In Article 14 Paragraph 3 of Law Number 23 of 2014 concerning Regional Government it is stated that only the central government can manage oil and gas business activities. -Law Number 22 of 2001 concerning Oil and Gas still regulates the authority/involvement of local governments in fulfilling the clauses of the cooperation contract as an instrument of oil and gas business activities. The method used in writing this article is normative law. In this study, the authors want to know and obtain clarity about what the central authority over the oil and gas business is, and how the revenue-sharing funds are divided for the two local governments. The literature used in this paper comes from scientific journals and is supported by scientific books from various scientists. From the results of the research that has been done, in fact there is still involvement of local governments both in management in the form of fulfilling the clauses of the cooperation contract, especially in determining the work area and its return as well as environmental management.
Cancellation of Notary Deed Based on Agreement of The Parties Through Deed of Cancellation
Authors: Amalia Thalita Reizky , Soroinda Disriani Latifah
Published: August 2024

An authentic deed is a form as written evidence that has perfect evidentiary power or so called fautless evidence. A deed can be declared as an authentic deed if it fulfil all the terms in article 1868 of Burgerlijk Wetboek, where the deed is made in the presence of or made by public functionary, namely a notary. As a public functionary that has an authority and obligations that clearly regulated in law, when carrying out his duties a notary must follows  the notary’s act and the Code of Ethics. A notarial deed cannot be canceled immediately but must go through the correct process to remove the binding status of the deed. This research was conducted to provide an understanding of the proper and correct ways for cancellation of notarial deeds that can be carried out by the parties. The research methods that uses is doctrinal research methods, with secondary data which is divided into 3 legal materials, namely, primary, secondary and tertiary which are analyzed to answer the problems in the thesis. A deed made by a notary has binding legal force for each parties in the deed, as well with regulated third party in the deed. By the process, a deed can be invalidated or annulled if it does not fulfil the formal or material terms, either based on a lawsuit by one of the parties through a the decision of a court from judge, or based on the mutual agreement of the parties through a deed of cancellation.
Pengembangan Materi dan Bahan Ajar PAI Dengan Model Dick And Carey
Authors: Fauziah Erika , Rohmah Ucik Saidatur
Published: August 2024

The Dick and Carey’s model is a learning model that has procedures with an instructional design consisting of systematic steps, consisting of cognitive and behavioral elements that require student responses to the material presented. So that this learning model is suitable with PAI materials and teaching materials, and can include knowledge, attitudes and skills, which are learning-oriented.
Problematika Guru Dalam Pengunaan Vidio Youtube Sebagai Media Pembelajaran di SMPN 1 Sidorejo
Authors: Auliya Rifqi Fadhillah , Khusniati Rima , Giar Fatnawa Rizky , Riski Awwalin Rista
Published: August 2024

The purpose of this research is to examine the problems of internal teachers using YouTube videos as learning media at SMPN 1 Sidorejo, so this research is important to do. This type of research is descriptive research with a qualitative approach. Collection method data using interviews, observation, and documentation with using research tools in the form of interview guides. Data obtained in research, it is researched descriptively by means of reduction, presentation, and drawing conclusions. The results of this research on problems that identified can be used as a reference for teachers to solve problems when using YouTube videos as a medium for learning and achieving higher quality learning. The limitations of this research are: teacher problems in the realm of junior high school learning at SMPN 1 Sidorejo.
Older people in English-based advertising discourse
Authors: Чупрына О.Г.
Published: August 2024

Для современного общества характерно противоречие между активным использованием людей возраста 50+ в качестве энергичной рабочей силы и незначительной их представленностью в интенсивно развивающемся рекламном дискурсе. Объект представленного в статье исследования — рекламный дискурс, актором которого является пожилой человек. Предмет исследования — оценочный аспект вербального и невербального представления старости и людей старшего возраста в англоязычной рекламе. Статья нацелена на решение проблемы модальности рекламных произведений, транслирующих отношение общества к пожилым людям и их отношение к обществу. Результаты исследования говорят о том, что оценка субъектом рекламного произведения его объекта выражается через ситуативный контекст и его вербальное наполнение. Когнитивные основания исследуемой рекламы делятся на стереотипные представления о людях 50+ и формирующееся современное восприятие представителей «серебряного» возраста. Для первых характерна псевдо-аффективность и антагонизм взаимодействия «молодые — старые», для второго — равновесная оценка молодых и пожилых.

Older generation is considered as a challenge for advertising industry. People 50+ are actively involved in manufacturing and seriously contribute to DDP in English-speaking countries. Nevertheless, their presence in commercials and other types of ads is almost invisible. The paper is anchored to the advertising discourse with an older person as a central actor. It specifies how older people are assessed in creolized advertising texts and commercials. The research subject is modality of ads translating the societal attitude towards gold agers and their attitude towards a society. Analysis reveals that the subject of a commercial or copy assesses its object with the help of a situation context and its verbal content. Cognitive patterns of advertising products fall into stereotypical perception of people 50+ and emerging contemporary comprehension of gold agers. The first is associated with the pseudo-affection and antagonistic relationship “the younger — the older” while the second equalizes the assessment of both — the young and the old.
Problem statement and methods for the computing resources distribution in geo-distributed heterogeneous computing environments with dynamics and restrictions on the execution time of tasks
Authors:   Russian State University for Humanities, Klimenko Anna B.
Published: August 2024

An analysis of the presented formulations of problems of distribution of computing resources has shown that to date there is no formalization of taking into account the properties of geodistribution, heterogeneity and dynamics of computing environments, subject to the existence of a limit on the execution time of user tasks. The purpose of this article is to develop a new general formulation of the problem of distribution of computing resources for geo-distributed heterogeneous computing environments with dynamics and a set of methods for solving it. The novelty of the research results is the new formulation of the problem for the specified class of computing environments, which differs from the existing ones by the complex integration of controlled parameters for the use of computing resources for data transit and the computational complexity of the procedure for allocating resources in the formal formulation of the problem of distribution of computing resources, as well as a set of methods for solving the problem, which differ from existing ones, taking into account the parameters of the computational complexity of the procedure for distributing the computational load and the characteristics of nodes in transit sections of the network. Within the framework of the study, discrete optimization methods are used, including iterative stochastic numerical optimization methods. The developed set of methods reduces the use of computing resources during the operation of the computing environment and, as a consequence, other resources that depend on the load on the computing nodes. The experimental results confirm the effectiveness of the developed set of methods, making it possible to reduce the use of computing resources for the process of their allocation by up to 2 times, as well as to reduce the execution time of a set of tasks by up to 2 times while maintaining the level of device load due to the selection of algorithmic implementation of data processing.
La Importancia de los Sistemas de Riego para el Uso Eficiente del Agua en la Agricultura
Authors: López Medina Manuel Salvador , Neri Ramirez Efrain , Rodríguez Morán Héctor Manuel , Moreno Ramírez Yolanda del Rocío , Rocandio Rodríguez Mario , Segura Martínez Teresa de Jesús
Published: August 2024

Las bajas precipitaciones que se han presentado en la última década han traído consigo una baja disponibilidad de este recurso, aunado a esto, la agricultura en México concentra el 77 % del agua consuntiva disponible, por ello, es necesario contar con el sistema de riego más eficiente disponible para cada tipo de cultivo, tipo de suelo, topografía, capital y condiciones climáticas del sitio donde se instalara, de manera que, se estableció como objetivo de este trabajo determinar el grado de eficiencia de los diferentes sistemas de riego. Para lo cual se realizó una revisión sistemática de literatura: libros, artículos de revistas como Scielo, Redalyc, Dialnet, Scopus, entre otros documentos académicos, para sintetizar las ideas principales y hallazgos a través del tiempo. Los resultados indicaron que no existe un sistema de riego que pueda ser utilizado para todo tipo de cultivo, topografía y tipo de suelo, sin embargo, resulta necesario aumentar el grado de tecnificación de riego en el sector agrícola, además de la implementación de técnicas que eficienticen el uso del agua, para ello es necesario que los sectores público y privado inviertan recursos para que el sector agropecuario migre hacia la tecnificación y un mejor uso del agua.
La importancia de la metodología en la psicología forense para los tribunales. Un estudio de caso sobre el análisis y opinión técnica
Authors: Martínez Díaz Edgar Israel
Published: August 2024

El presente trabajo deviene de un estudio de caso, basado en nuestra praxis pericial, el cual, versó sobre el análisis y opinión con respecto a un dictamen en materia psicológica emitido por la Fiscalía del Estado de Sinaloa en México, para determinar su estatus técnico en razón de la metodología empleada por los peritos oficiales, con la que se asegura “soportaron” sus conclusiones periciales (se omiten nombres y datos sensibles de todos los involucrados, así como criterios para la identificación del asunto legal). El fin, fue analizar el procedimiento que utilizaron éstos, con el que fundamentaron la prueba, misma que, señaló a personas y hechos de un delito de abuso sexual cometido en contra de una menor de edad, y que motivó nuestra participación, en el cual, se examinó el documento legal para establecer si de acuerdo al procedimiento técnico que utilizaron los psicólogos en cuestión pudieron arribar a las conclusiones; para esto, se estableció si existió o no, una metodología “dura” que respetara los criterios de idoneidad y suficiencia en el marco de la pertinencia que debe de tener toda evaluación clínica psicológica que se encamina para dilucidar un conflicto en los tribunales; dado que, los “especialistas” arribaron en su diagnóstico que la niña examinada (en adelante llamaremos Renata), presentó un sufrimiento psico-emocional,  que existió una correlación positiva entre el discurso de su proceso de entrevista psicológica, los signos y síntomas de dicho sufrimiento, basado en los estudios que practicaron. La denuncia se llevó a cabo por la madre de Renata en abril del 2014, donde se acusa al padre, como responsable de dichos actos.
Association between Treatment Adherence and Depression in Patients with HIV/AIDS
Authors: Tienda-Pimentel Marcos Ivan , Rodríguez Román Eréndira , Jiménez Morales Ingrid , Torres Dibildox Ana Sofia
Published: August 2024

Background: Depression represents a significant issue among individuals diagnosed with HIV. A study conducted in Africa revealed that the prevalence of depression in this patient population may reach 63.1%. In Mexico, however, there is no existing literature on this matter. Antiretroviral therapy (ARV) is a vital component of treatment for individuals with HIV/AIDS. However, the efficacy of ARV may be compromised by poor adherence to treatment. The lack of adherence may be attributed to psychological factors, such as depression. Objective: To determine the presence and severity of depression and its relationship with adherence to treatment in patients with HIV/AIDS. Methods: A quantitative, non-experimental, cross-sectional, and non-interventional study was conducted at the High-Specialty Regional Hospital ISSSTE (Institute for Social Security and Services for State Workers) in Veracruz, Mexico. Unit of analysis: 977 individuals, selected according to the pre-established inclusion and exclusion criteria, with a confidence level of 99% and a confidence limit of 3.8%. Discussion: The lack of adherence to treatment in patients with HIV/AIDS was found to be directly proportional to the presence and severity of depression. Depression was identified in 81.17% of the total sample. 62.79% exhibited mild depression, 16.27% demonstrated moderate depression, and 20.93% displayed severe depression. In patients with poor adherence to treatment, severe depression was found in 91.37%. Additionally, comorbidities such as diabetes and hypertension were observed with a higher frequency than reported in literature. Conclusion: We recommend establishing a systematic and individual psychological evaluation of HIV/AIDS patients and initiating measures for the early detection of depression. This approach will help to prevent a possible interruption or abandonment of antiretroviral treatment, and therefore therapeutic failure.
High-quality human resources in sustainable socio-economic development in Vietnam
Authors: Nguyen Minh Tri , Pham Ngoc Thanh , Nguyen Quoc Thang
Published: August 2024

The globe is currently experiencing swift and ground breaking transformations, where the crucial element influencing significant economic and social shifts is top-notch resources. In today's landscape, the rivalry among nations and enterprises primarily revolves around intellectual capacity, representing the knowledge encapsulated in products, commodities, and services facilitated by high-caliber human resources. To attain rapid and enduring progress, countries worldwide are directing their attention toward the development of human resources, recognizing it as a strategic and pressing concern within the framework of global economic globalization. Consequently, developing high-quality human resources stands out as a pivotal factor aiding Vietnam in enhancing its competitive edge and aligning with the demands of the contemporary digital economy. This piece delves into the role of advancing human resources, emphasizing how high-quality human resources align with the prerequisites of sustainable development.
Corona: Covid 19 Presentation as Motor Neuron Disease Corona: A Motor Neuron Disease
Authors: Kumar Jain Anil
Published: August 2024

Breathing difficulty, difficulty in Deglutition, generalized weakness, pain weakness on the side of lying down., gastroparesis, numbness Constipation, increase sleep hyperglycaemia type 2 Diabetes hypothyroidism, Hypotension, Hypoxia, Irritability, Hair fall.
A tüntetések világa a jog tükrében. Hajas Barnabás: Utcák, terek szabadsága. Kézikönyv szervezőknek, tüntetőknek, rendőröknek és bámészkodóknak (207–212)
Authors: Szabó Máté
Published: August 2024

The study examines the practical issues of the regulation of the right of assembly, with special reference to the police tasks and enforcement dilemmas in Hungary since 1989. It shows that the right of assembly plays an important role in the protection of democracy and human rights, and describes the problems encountered in interactions between police and demonstrators. The study stresses the importance of communication and conflict management to ensure peaceful demonstrations, and the need for the development of legal regulation and practice.
OPERATION AND DEVELOPMENT OF THE TOURIST COMPLEX IN THE ECONOMIC SPACE OF THE REGION IN THE CONDITIONS OF THE NEW REALITY
Authors:   Ural State University of Economics, NOVIKOVA NATALYA , DZHIMOVA SAIDA ,   Ural State University of Economics
Published: August 2024

The article substantiates the key problems of the functioning and development of the tourism complex in the economic space of the region in the conditions of an actively emerging new reality. The object of the study is one of the regions of the Russian Federation — the Republic of Adygea, in the economic space of which economic entities that are part of the tourism complex are important in ensuring socio-economic dynamics. The methods of the presented research are based on formalization and systematization approaches, bibliometric analysis and content analysis, and time series analysis.
The taste of the landing
Authors: Fiore Teresa
Published: August 2024

Inspired by Leonardo Sciascia’s novella ‘The American Aunt’, this article offers a new perspective on the 1943 Allied landing in Sicily, reading it through the lens of food practices and migration. Blending literary and historical analysis with the testimonies of direct witnesses of the landing, the article explores the role of food (access, products, symbolism) during late Fascism, the actual landing, and the post-1943 and post-Second World War era. The picture that emerges is a variegated landscape of experiences, pointing to starvation among the poor but also to food access for those Sicilians who lived in the countryside away from the bombarded cities, and in a Sciascia-like ironic twist, to the Sicilians’ offer of fresh flavourful food to US soldiers weary of the military pre-packaged food. The article complicates the assumption that all Sicilians were starving at the time of the landing and waiting to be fed by the American soldiers coming from the Land of Abundance, a representation created by a mixture of one-sided perspectives of the war along with decades of emigration to the United States.
Combination of resveratrol and piperine to target doxorubicin resistance in breast cancer: An in vitro and in vivo study
Authors: AlHur Mallak J. , Barakova Nadezhda , Talib Wamidh H.
Published: August 2024

One of the biggest causes of death worldwide is cancer, which poses a serious threat to healthcare systems all over the world. Triple-negative breast cancer (TNBC), in particular, presents substantial clinical challenges because it does not express Human Epidermal Growth Factor Receptor 2 (HER2) or hormone receptors. Despite concerns about early recurrence and drug resistance, chemotherapy, particularly anthracyclines like Doxorubicin (DOX), remains the mainstay of treatment for TNBC patients. This research investigates the possibility of using natural products, especially piperine (PIP) and resveratrol (RES), to overcome DOX resistance. PIP and RES have shown anticancer effects via various pathways, such as inducing apoptosis and controlling the cell cycle. In this research, in vitro experiments showed that RES and PIP inhibit cell growth in a dose-dependent manner using triple-negative parent mouse mammary breast cancer cells and DOX resistance cells (EMT-6/P and EMT-6/DOX). RES in EMT-6/P cells showed an IC50 value of 146.511 ± 5.35 μM, and in EMT-6/DOX cells, it was 88.635 ± 29.507 μM. In the same way, PIP was found to have IC50 values of 148.819 ± 14.317 and 9.375 μM in the triplicate trials in EMT-6/P and EMT-6/DOX, respectively. Furthermore, on both cell lines, the combination demonstrated very strong synergistic effects; noticeably lower doses were needed for the combined treatment to reduce cell viability by 50%. The IC50 values for the combination treatments of RES and PIP were found to be < 2.289 µM and < 2.325 µM in EMT-6/P cells, respectively, with values < 0.348 µM and 0.243 ± 0.142 µM in EMT-6/DOX cells. The in vivo experiment conducted on Balb/C females indicated that mice bearing EMT-6/Dox cells and treated with the combination of RES and PIP had the highest cure percentage; however, this treatment showed mild toxicity. The study clarifies the potential synergistic activity between PIP and RES in combating DOX-resistant TNBC cells. These findings highlight the significance of investigating natural products as supplemental therapies in cancer treatment and provide insights into new treatment approaches. While the combination shows promise as a therapeutic option for treating breast cancer, especially in cases of DOX resistance, further investigation is needed.
A Cost Analysis of Traditional Versus Robotic Total Knee Arthroplasty Performed With an Imageless, Second-generation Robotic System
Authors: Leal Justin , Cochrane Niall H. , Kim Billy I. , Holland Christopher T. , Hallows Rhett , Seyler Thorsten
Published: August 2024

Background

This study compared perioperative outcomes as well as encounter and 90-day costs between patients undergoing traditional vs robotic total knee arthroplasty (rTKA).

Materials and Methods

A total of 430 TKAs (215 rTKAs, 215 traditional) were retrospectively reviewed. All rTKAs were performed with an imageless, second-generation robotic system. Cohorts were propensity score matched by age, sex, body mass index, and American Society of Anesthesiologists score. Perioperative data and 90-day complications were subsequently compared. Cox regression analyses evaluated survival to all-cause revisions. Univariable analyses compared total cost of care for the initial encounter and 90-day postoperative period. Multivariable regression analyses were then performed to evaluate associations with increased encounter and 90-day costs.

Results

Patients undergoing rTKA had a higher incidence of discharge home (86.5% vs 60.0%;
P
<.001). The rTKA cohort trended toward a lower incidence of 90-day emergency department visits, and there was a significantly lower percentage of 90-day readmissions (4.2% vs 13.5%;
P
=.001). Cox hazard ratio demonstrated no difference in survival to all-cause revisions (hazard ratio, 1.3; 95% CI, 0.5–3.7;
P
=.64). The cost of surgery was significantly higher in the rTKA cohort ($9292 vs $8392;
P
<.001); however, there was no difference in cost of encounter ($10,356.86 vs $10,396.44;
P
=.110) or at 90 days postoperatively ($11,103.89 vs $11,040.13;
P
=.739). rTKA did not have a significant association with increased cost at 90 days postoperatively (odds ratio, 0.96; 95% CI, 0.90–1.02;
P
=.180).

Conclusion

rTKA had a higher intraoperative cost compared with traditional TKA. However, with increased home discharges and fewer 90-day readmissions, rTKA was not associated with increased cost at 90 days. [
Orthopedics
. 2024;47(6):365–371.]
Surgeons Who Perform Total Hip Arthroplasty Are at Risk for Noise-Induced Hearing Loss, Especially When Using Automated Broaching
Authors: Lutz Rex W. , Ponzio Danielle , Kwan Stephanie A. , Thalody Hope S. , Cheesman Quincy , Patrizio Harrison A. , Ong Alvin C. , Deirmengian Gregory K.
Published: August 2024

Background

Noise-induced hearing loss (NIHL) is a serious concern for orthopedic surgeons. The National Institute for Occupational Safety and Health (NIOSH) sets the safe exposure limit at 85 dB for 8 hours, yet operating rooms often surpass this limit. This study investigated if using an automated broaching system exposes orthopedic surgeons to dangerous decibel (dB) levels.

Materials and Methods

A prospective study analyzed 138 intraoperative sound recordings from 92 total hip arthroplasty (THA) surgeries and 46 baseline measurements at an academic-affiliated private practice, using the NIOSH Sound Level Meter (SLM) application and a microphone. The surgeries were categorized into manual and automated broaching. Key metrics measured included maximal dB level (MDL), peak sound pressure (LC
peak
), average continuous sound (LA
eq
), and average weighted sound in an 8-hour period (TWA), along with dose representations, to identify hazardous noise levels.

Results

Of the 92 THA sound recordings, 50 used manual broaching and 42 employed automated broaching. Automated broaching exhibited higher noise levels, with an average MDL of 109.92 dBA, a LA
eq
of 86.09 dBA, a TWA of 76.48 dBA, and a projected noise dose of 137.74%. In contrast, manual broaching exhibited an average MDL of 105.87 dBA, a LA
eq
of 83.06 dBA, a TWA of 72.82 dBA, and a projected noise dose of 82.02%.

Conclusion

This study highlights the auditory risks from automated broach and manual THA surgeries that orthopedic surgeons experience. Manufacturers should focus on reducing instrument noise when designing surgical tools and orthopedic surgeons and operating room staff should take measures to protect themselves from NIHL during surgery. [
Orthopedics
. 2024;47(6):349–354.]
Full-Thickness Macular Hole in a Pediatric Patient With Normal Vision
Authors: Forati Rasadokht , Hoyek Sandra , Romano Francesco , Miller John B. , Patel Nimesh A.
Published: August 2024

A 17-year-old boy presented with a full-thickness macular hole, with 20/20 vision with eccentric fixation in the left eye. Examination of the left eye showed a large macular hole with a base diameter measuring 1,680 μm and temporal macular and mid-peripheral retinal atrophy on ultra-high-definition optical coherence tomography (OCT) scans. Microperimetry showed eccentric fixation with good nasal sensitivity. A 12 x 12-mm extended-field swept-source OCT angiogram showed flow loss in the temporal macula, with slight reduction noted in the choriocapillaris. Given excellent visual acuity, good tolerance by the patient, and large atrophic hole, the decision was made for observation rather than surgery.

[
Ophthalmic Surg Lasers Imaging Retina
2024;55:607–612.]
A weak Galerkin finite element method for parabolic singularly perturbed convection-diffusion equations on layer-adapted meshes
Authors: Toprakseven Suayip , Dinibutun Seza
Published: August 2024

In this paper, we designed and analyzed a weak Galerkin finite element method on layer adapted meshes for solving the time-dependent convection-dominated problems. Error estimates for semi-discrete and fully-discrete schemes were presented, and the optimal order of uniform convergence has been obtained. A special interpolation was delicately designed based on the structures of the designed method and layer-adapted meshes. We provided various numerical examples to confirm the theoretical findings.
The green finance dilemma: No impact without risk – a multiple case study on renewable energy investments
Authors: Grumann Laura , Madaleno Mara , Vieira Elisabete
Published: August 2024

Recently, European regulation on sustainability preferences has made green finance a mainstream topic for retail investors. On the contrary, green innovation is largely discussed as bearing risks, and renewable energy projects are sometimes referred to as related to high risk. Our article aimed to shed light on retail investors' risk exposure in green finance. In the literature review, we rarely found the retail investor's risk perspective reflected, and green finance risk in terms of major capital loss was not explicitly stated as a research topic. We aimed to close this gap in the literature and apply a multiple case study approach with cases from the renewable energy sector to analyze the components that nurture green finance risk. For case description, we leveraged publicly available online information such as press articles, financial reporting, mandatory disclosure from the represented company, and pre-contractual information of the financial instruments marketed. Our findings suggest that green finance risk (GFR) is nurtured by risk components from the categories of financial instrument risk (FIR), investee company risk (ICR), and operational risk (OR) of renewable energy projects. The cross-case analysis identified red flags that might alert future investors. Additionally, we suggested measures to mitigate green finance risk and propose regulatory improvements. Our research marks a starting point for future quantitative and qualitative research.