bluuebunny/crossref_metadata_2025 huggingface dataset:
DDSolver Software Application for Quantitative Analysis of In vitro Drug Release Behavior of the Gastroretentive Floating Tablets Combined with
Radiological Study in Rabbits
Authors: Abdul Rasool Bazigha K. , Sammour Rana
Published: March 2022

Background:

Gastroretentive drug delivery systems (GRDDSs) are designed to release the
drug in the stomach over a prolonged time; thus, they can reduce drug dosing frequency and dose size
and improve patient compliance. GRDDSs are also highly effective in enhancing the bioavailability of
the drug that exhibits window absorption in specific segments of the gastrointestinal (GI) tract. Famotidine
(FMT), an H2 receptor antagonist, is an example of these drugs. FMT is a slightly watersoluble
drug but well soluble in an acidic medium. This research aims to formulate FMT gastroretentive
floating tablets (FMT-GRFTs) to improve the bioavailability and therapeutic activity of the
drug and increase patients' adherence to treatment. In addition, the in vitro release behavior of the prepared
FMT-GRFTs was quantitatively analyzed using the DDSolver software to assist in selecting the
successful formulation that was then evaluated in vivo.

Methods:

The direct compression technique prepared numerous tablet formulations and was subjected
to the pre-and post-compression evaluation. Data of FMT dissolution in the simulated gastric medium
was analyzed by various kinetic models built in the DDSolver program. In addition, the simulated
pharmacokinetics (AUC, MDT, and MRT), R2 adjusted, AIC, MSC, correlation of the residuals, and
similarity factor (f2) were also generated.

Results:

The results revealed that FMT release from the candidate formula (FH3) fitted to the first-order
kinetic model, with a high value of R2 adjusted and MSC and a low AIC. The release behavior exhibited
the Fickian diffusion mechanism. The similarity factor showed no significant difference (p < 0.05) of
the test sample compared to the reference product. Nevertheless, the simulated pharmacokinetic parameter,
AUC, proved a two-fold enhancement in FMT bioavailability, with a significant increment in the
MDT and MRT compared with the reference product. The FT-IR spectroscopy analysis indicated the
absence of drug-excipients/polymer interaction. The in vivo X-ray studies on rabbits confirmed that the
floating tablets showed nearly eight hours of gastric residence.

Conclusion:

DDSolver software was helpful in deciding the optimized formulation of FMT floating
tablets. The radiological examination in rabbits for gastric retention was consistent with the release data
analysis in vitro.
Antioxidant and Antimicrobial Potential, BSA and DNA Binding Properties
of Some 3-Hydroxy-3-Pyrrolin-2-Ones Bearing Thenoyl Fragment
Authors: Joksimović Nenad , Petronijević Jelena , Milović Emilija , Janković Nenad , Kosanić Marijana , Petrović Nevena
Published: March 2022

Background:

It is known that pyrrolidinone derivates belong to a class of biologically
active compounds with a broad spectrum of biological actions. Nowadays, many scientists are making
an effort in the discovery of more effective ways to eliminate reactive oxygen species (ROS) that
cause oxidative stress or to eliminate the harmful microorganisms from the organism in humans.
Therefore, pyrrolidinones seem to be great candidates for the research of this field.

Methods:

The antimicrobial activity of tested compounds was estimated by the determination of the
minimal inhibitory concentration by the broth micro-dilution method against four species of bacteria
and five species of fungi. The antioxidant activity was evaluated by free radical scavenging and reducing
power.

Results:

Among the tested compounds, P22 showed marked antibacterial activity on Staphylococcus
aureus with a MIC value of 0.312 mg/mL. Maximum antifungal activity with MIC value 0.625
mg/mL was shown by P23 and P25 compounds against Trichophyton mentagrophytes. Tested samples
showed a relatively strong scavenging activity on DPPH radical (IC50 ranged from 166.75-
727.17 μg/mL). The strongest DPPH radical scavenging activity was shown by P3 compound with
an IC50 value of 166.75 μg/mL. Moreover, the tested compounds had effective reducing power.
Compounds P3, P10, and P13 showed the highest reducing power than those from the other samples.
Results of the interactions between DNA and P3 indicated that P3 had the affinity to displace EB
from the EB-DNA complex through intercalation [Ksv = (1.4 ± 0.1) × 105 M-1], while Ka values obtained
via titration of BSA with P23 or P25 [Ka = (6.2 ± 0.2) and (5.0 ± 0.2) × 105 M-1] indicate
that the notable quantity of the drug can be transmitted to the cells.

Conclusion:

Achieved results indicate that our compounds are potential candidates for use as
medicaments.
Stem Cell Application for Stress Urinary Incontinence: From Bench to
Bedside
Authors: Liu Meng , Wang Ying , Gao Guo , Zhao Wei-Xin , Fu Qiang
Published: March 2022

Stress urinary incontinence (SUI) is a common urinary system disease worldwide. Nowadays,
medical therapy and surgery can control the symptoms and improve the life quality of patients. However,
they might also bring about complications as the standard therapy fails to address the underlying problem
of urethral sphincter dysfunction. Recent advances in cell technology have aroused interest in the use of
autologous stem cell therapy to restore the ability of urinary control. The present study reviewed several
types of stem cells for the treatment of SUI in the experimental and clinical stages.
Advancement in Nanoformulations for the Management of Diabetic Wound
Healing
Authors: Bhadauria Shailendra Singh , Malviya Rishabha
Published: March 2022

People with diabetes have a very slow tendency for wound healing. Wound healing is a vast process where several factors inhibit the sequence of healing. Nano-formulations play a major role in acute and chronic wound healing. The present manuscript aims to discuss the role of nano-formulations for diabetic wound healing treatment. Diabetes is a common disease that has harmful consequences which over the time lead to serious damage to many of the body's systems, especially the nerves and blood vessels. During the literature survey, it was observed that nanotechnology has significant advantages in the treatment of diabetic wound healing. The present manuscript summa-rized the role of nanomaterials in wound healing, challenges in diabetic wound healing, physiology of wound healing, limitations that come during wound repair, and treatments available for wound healing. After a comprehensive literature survey, it can be concluded that health worker needs more focus on the area of wound healing in diabetic patients. Medical practitioners, pharmaceutical, and biomedical researchers need more attention towards the utilization of nano-formulations for the treatment of wound healing, specifically in the case of diabetes.
Peritoneal carcinomatosis and mimicking on CT scan findings
Authors: Rahma Devy Yuspita , Atmaja Muhammad Hidayat Surya
Published: March 2022

Peritoneal carcinomatosis (PC) is a term to describe the distant spread (metastatic) of the primary tumor to the peritoneal cavity. PC is a late-stage manifestation of various gastrointestinal malignancies in general and affects the ovaries, which is characterized as tumor deposits involving the surface of the peritoneal wall. If no primary signs are found, the primary diagnosis can be considered from the peritoneum itself. PC itself can be found incidentally on imaging, which can be seen on computed tomography examination, but in some mimicking images making it difficult to make a diagnosis, it is necessary to correlate it with the histopathological results.
Development of model training mentoring in improving assistant competence in the convection group of businesses
Authors: Djibu Rusdin , Shofwan Imam
Published: March 2022

This research aims to develop a mentoring training model to improve the competence of the assistant in the convection group in the city of Gorontalo. The approach used in this research is qualitative. The methods used are research and development (R D) which include the following activities: (1) Preliminary review of the initial condition of competence of convection assistants, (2) Development model Mentoring, (3) expert validation and revision, (4) implementation of the model , (5) test the effectiveness of the model, and (6) model recommendation. The results of Development Studies show: (1) initial condition of convection competence of the general do not follow the standards of convection assistant, because the convection assistant has not received training, (2) The development of training model mentoring to Increase the competence of convection assistants conducted through several steps; Conducting analysis of development needs, determining the elements to be developed, developing a mentoring model to improve quality and productivity, validating model development with non-formal education experts, educational practitioners Non-formal and peer, and compile the final model, (3) Implication model assistance is conducted thorough testing and testing model assistance. All these activities are done through stages; Planning, organizing, implementing, evaluating, and delivering results. (4) The development of a training model affects the effectiveness and efficiency of training implementation. Effectiveness tests are conducted through post-test. Research findings suggest that the training model of mentoring to improve the competencies developed by the convection Assistant is recommended for the interested parties.
Peningkatan kualitas layanan pos PAUD melalui penyusunan program penguatan Pendidikan karakter berbasis masyarakat
Authors: Wahyuni Sri , Aisyah Eny Nur , Redjeki Endang Sri
Published: March 2022

Tujuan kegiatan ini adalah meningkatkan partisipasi masyarakat pada layanan lembaga Pos PAUD. Kegiatan pelatihan ini dilaksanakan selama 2 hari dengan 30 peserta dari Pos PAUD di Kecamatan Sukun Kota Malang. Pelatihan diselenggarakan dengan metode two in one training, yang memadukan teori dan praktek penyusunan SOP (Standart Operational Procedure), Brand-ing Sekolah, dan identifikasi pelibatan potensi masyarakat. Melalui pelatihan ini pemahaman guru terhadap PPK Berbasis Masyarakat dan PPK Berbasis Budaya Sekolah meningkat, terbukti dari skor pretest 52,4 menjadi 86,2 pada saat post test. Output yang diperoleh dari kegiatan ini adalah tersusunnya rancangan program PPK berbasis masyarakat dan teridentifikasi lembaga mitra. Setiap lembaga Pos PAUD juga mampu menyusun branding sekolah. Penyelenggaraan pelatihan secara umum dinilai sangat baik oleh peserta dengan skor rata-rata 90,2. Hal ini bermakna bahwa peserta senang mengikuti pelatihan, materi sesuai dengan kebutuhan, metode pelatihan menyenangkan, media yang digunakan sesuai dengan materi, ruangan nyaman dan peserta dilibatkan secara aktif dalam proses. Improving the quality of pos PAUD services through the development of community-based character education program strengthening AbstractThe purpose of this activity is to increase community participation in the services of Pos PAUD institutions. This training activity was held for 2 days with 30 participants from Pos PAUD in Sukun District, Malang City. The training was conducted using the two in one training method, which combines the theory and practice of preparing SOP (Standard Operational Procedure), School Branding, and identification of potential community involvement. Through this training the teacher's understanding of Community Based PPK and School Culture-Based PPK increased, as evidenced by the pretest score of 52.4 to 86.2 at the time of the post-test. The output obtained from this activity is the preparation of community-based PPK program designs and identified partner institutions. Every Pos PAUD institution is also able to compile school branding. The organization of training was generally rated very well by participants with an average score of 90.2. This means that the participants like to attend the training, the material is in accordance with their needs, the training methods are fun, the media is used according to the material, the room is comfortable and participants are actively involved in the process
Optimalisasi pembelajaran self-study pada program Paket A di pusat kegiatan belajar masyarakat di masa pandemi
Authors: Rustan Edhy , Baderia Baderia , Tamrin Rahmat
Published: March 2022

Pandemi COVID-19 mensyaratkan social distance, sehingga pembelajaran mandiri perlu dimaksimalkan. Tujuan penelitian ini adalah untuk memaparkan (1) bentuk pembelajaran self-study, (2) kendala, dan (3) manfaat pembelajaran self-study pada program paket A di PKBM Rantenase selama pandemic COVID-19. Penelitian ini merupakan penelitian deskriptif kualitatif. Subjek penelitian ini adalah pengelola, tutor, dan warga belajar program paket A. Metode pengumpulan data menggunakan wawancara, observasi, dan dokumentasi. Data yang diperoleh kemudian dianalisis interaktif dengan cara reduksi, penyajian, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa pembelajaran mandiri di PKBM Rantenase dilaksanakan dengan tutor mengarahkan peserta didik melalui pesan SMS maupun Whatsapp sedangkan evaluasi diganti dengan penugasan. Kendala yang ditemui selama pembelajaran di masa pandemic yakni kendala teknis seperti akses jaringan, ketersediaan sarana dan prasarana serta sumber belajar. Sedangkan kendala nonteknis yakni karakteristik warga belajar. Manfaat pembelajaran self-study memperkuat literasi fungsional terutama keterampilan literasi digital, membangkitkan semangat penggerak pemberdayaan masyarakat terutama dalam pembelajaran meski dengan segala keterbatasan. Peserta didik memperoleh pengalaman belajar yang bermakna, berdasarkan potensi dan kebutuhannya. Optimization of self-study learning in the Paket A program at the community learning activity center during the pandemic Abstract: The COVID-19 pandemic requires social distance, so independent learning needs to be maximized. The purpose of this study was to describe (1) the form of self-study learning, (2) constraints, and (3) the benefits of self-study learning in the package A program in PKBM Rantenase during the COVID-19 pandemic. This research is a qualitative descriptive study. The subjects of this study were managers, tutors, and learning citizens of the package A program. Data collection methods used interviews, observation, and documentation. The data obtained were then analyzed interactively by means of reduction, presentation, and drawing conclusions. The results showed that independent learning in PKBM Rantenase was carried out with a tutor directing students via SMS or Whatsapp messages while assignments replaced evaluation. The obstacles encountered during learning during the pandemic were technical problems such as network access, the availability of facilities and infrastructure, and learning resources. Meanwhile, non-technical constraints are the characteristics of the learning community. The benefits of self-study learning strengthen functional literacy, especially digital literacy skills, arouse the spirit of community empowerment, especially in learning even with all the limitations. Learners gain meaningful learning experiences based on their potential and needs.
Pemberdayaan kelompok tani melalui pembuatan bioenergi pertanian dari limbah batang pisang
Authors: Nurhamidah Nurhamidah , Elvia Rina , Handayani Dewi , Amida Nadia , Palenti Citra Dwi
Published: March 2022

Kabupaten Kepahiang merupakan sentra produksi sayur-sayuran dan buah-buahan salah satunya buah pisang. Kualitas produksi sangat bergantung pada proses pemeliharaan dan pemupukan yang harganya sangat memberatkan dan menjadi permasalahan bagi petani. Pasca panen, batang pisang akan dibiarkan sebagai limbah padahal batang pisang berpotensi sebagai bioenergi pertanian. Berkaitan dengan permasalahan dan potensi tersebut maka dilaksanakan  kegiatan pengabdian yang bertujuan untuk memberikan pengetahuan dan motivasi kepada masyarakat Desa Tapak Gedung Kecamatan Tebat Karai Kabupaten Kepahiang Propinsi Bengkulu dalam memanfaatkan limbah pisang. Kegiatan ini dilakukan dengan menggunakan Metode Participatory Action Research (PAR) melalui 3 strategi yaitu Sosialisasi, Pelaksanaan serta monitoring dan evaluasi program. Data dikumpulkan melalui teknik observasi, Fosused Group Discussion (FGD), wawancara, praktek lapangan dan dokumentasi. Kegiatan ini disambut baik dan antusias oleh masyarakat Desa Tapak Gedung. Masyarakat merasa sangat terbantu dalam penyedian pupuk organik dalam menunjang usaha pertaniannya. Berdasarkan strategi yang dilakukan dapat disimpulkan bahwa kegiatan pemberdayaan kelompok tani melalui pembuatan bioenergi pertanian dari limbah batang pisang dapat memberikan ilmu yang sangat membantu bagi masyarakat serta pembuatan pupuk organik dalam skala besar dapat dijadikan alternatife untuk peningkatan ekonomi masyarakat. AbstractKepahiang Regency is a center for the production of vegetables and fruits, one of which is bananas. The quality of production is very dependent on the maintenance and fertilization process, which is very expensive and a problem for farmers. After harvest, banana stems will be left as waste, even though banana stems have the potential as agricultural bioenergy. In connection with these problems and potential, community service activities were carried out aimed at providing knowledge and motivation to the people of Tapak Gedung Village, Tebat Karai District, Kepahiang Regency, Bengkulu Province in utilizing banana waste. This activity is carried out using the Participatory Action Research (PAR) method through 3 strategies: socialization, implementation, and monitoring and evaluation of the program. Data were collected through observation techniques, Focused Group Discussion (FGD), interviews, field practice and documentation. This activity was welcomed and enthusiastically by the people of Tapak Gedung Village. The community feels very helpful in providing organic fertilizers to support their agricultural business. Based on the strategy carried out, it can be concluded that the activities of empowering farmer groups through the manufacture of agrarian bioenergy from banana stem waste can provide knowledge that is very helpful for the community, and the manufacture of organic fertilizers on a large scale can be used as an alternative to improve the community's economy.
Pariwisata Berbasis Masyarakat di Desa Sekapuk: Sebuah Participatory Action Research
Authors: Asmoro Agung Yoga , Yusrizal Firdaus , Saputra Indra
Published: March 2022

Abstrak: Penelitian ini bertujuan untuk memahami kondisi aktual kepariwisataan berbasis masyarakat (CBT) di Desa Sekapuk dengan menganalisis pelaksanaan prinsip-prinsip CBT. CBT patut diimplementasikan karena masyarakat adalah pihak yang seyogianya menjadi pelaku utama berbagai kegiatan kepariwisataan, sehingga manfaat dari pariwisata dapat dirasakan langsung oleh masyarakat. Penelitian ini merupakan Community-Based Research (CBR) yang dilakukan dengan pendekatan Participatory Action Research (PAR). Implementasi CBT di Desa Sekapuk secara garis besar sejalan dengan prinsip-prinsip CBT pada aspek: partisipasi dan pemberdayaan masyarakat; kemitraan dengan pemangku kepentingan terkait; pengakuan dari otoritas terkait; peningkatan kesejahteraan sosial; keadilan dan transparansi dalam pembagian manfaat; peningkatan hubungan dengan ekonomi lokal dan regional; dan kemandirian finansial.  Penelitian menemukan masih perlu ditingkatkan kinerja dalam aspek penghargaan terhadap budaya dan tradisi lokal, kontribusi terhadap konservasi sumber daya alam; dan upaya peningkatan pengalaman pengunjung. Community–Based Tourism in Sekapuk Village: a Participatory Action ResearchAbstract: This study aims to understand the actual conditions of community-based tourism (CBT) in Sekapuk Village by analyzing the implementation of CBT principles. CBT should be implemented because the local community is supposedly the main actors for various tourism activities to maximize the direct benefits of tourism. This research is Community-Based Research (CBR) conducted using the Participatory Action Research (PAR) approach. The implementation of CBT in Sekapuk Village is broadly in line with the principles of CBT in the aspects of community participation and empowerment; partnerships with relevant stakeholders; recognition from relevant authorities; increase in social welfare; fairness and transparency in benefit-sharing; improved relations with local and regional economies; and financial independence. The research found that performance needs to be improved in terms of respect for local culture and traditions, contribution to the conservation of natural resources; and visitor experience enhancement efforts.
The Participation of Fisherman Groups in Community Empowerment Activities (A Study of Community-Based Coral Reef Rehabilitation in Baurung, Banggae Timur, Majene)
Authors: Qadir Muhammad Muhtaj , Gunawan Budhi , Iskandar Iskandar
Published: March 2022

This study aims to describe (1) the comprehensive implementation of coral reef rehabilitation activities which have been carried out in Baurung Village, Banggae Timur District, Majene Regency, Sulawesi Barat, and (2) the participation of fisherman groups who have been directly involved in the coral reef rehabilitation activities. This study employs qualitative methods which data are collected through observation and interviews. The research participants were selected through purposive sampling and involved activity executor and the Head of the Fisherman Group from Samaelo dan Sipatuo. The results demonstrated that (1) The implementation of coral reef rehabilitation activities was carried out in four stages, namely preparation, implementation, monitoring/evaluation and maintenance, (2) The participation of fisherman groups shows that in the preparation and implementation stages, their participation is considered high, while their participation in monitoring/evaluation and maintenance stages tends to decrease. Therefore, it brings an impact to the activity results.
The Impact of Transitioning From In-Person to Virtual Heart Transplantation Selection Committee Meetings: Observational Study
Authors: Shan Rongzi , Chandra Neha V , Hsu Jeffrey J , Fraschilla Stephanie , Moore Melissa , Ardehali Abbas , Nsair Ali , Parikh Rushi V
Published: March 2022

Background

Heart transplant selection committee meetings have transitioned from in-person to remote video meetings during the COVID-19 pandemic, but how this impacts committee members and patient outcomes is unknown.

Objective

The aim of this study is to determine the perceived impact of remote video transplant selection meetings on usability and patient care and to measure patient selection outcomes during the transition period from in-person to virtual meetings.

Methods

A 35-item anonymous survey was developed and distributed electronically to the heart transplant selection committee. We reviewed medical records to compare the outcomes of patients presented at in-person meetings (January-March 2020) to those presented during video meetings (March-June 2020).

Results

Among 83 committee members queried, 50 were regular attendees. Of the 50 regular attendees, 24 (48%) were physicians and 26 (52%) were nonphysicians, including nurses, social workers, and coordinators; 46 responses were received, 23 (50%) from physicians and 23 (50%) from nonphysicians, with 41 responses fully completed. Overall, respondents were satisfied with the videoconference format and felt that video meetings did not impact patient care and were an acceptable alternative to in-person meetings. However, 54% (22/41) preferred in-person meetings, with 71% (15/21) of nonphysicians preferring in-person meetings compared to only 35% (7/20) of physicians (P=.02). Of the 46 new patient evaluations presented, there was a statistically nonsignificant trend toward fewer patients initially declined at video meetings compared with in-person meetings (6/24, 25% compared to 10/22, 45%; P=.32).

Conclusions

The transition from in-person to video heart transplant selection committee meetings was well-received and did not appear to affect committee members’ perceived ability to deliver patient care. Patient selection outcomes were similar between meeting modalities.
Editorial
Authors: Pacheco-Salazar Berenice
Published: March 2022

No necesita de un resumen.
Formación del profesorado, enseñanza y evaluación. Experiencias de estudiantes portugueses
Authors: Pinheiro Cláudia , Flores Maria Assunção , Cristóvão Francisco
Published: March 2022

Este artículo, procedente de un estudio más amplio, trata de comprender cómo los estudiantes que serán futuros profesores describen su experiencia en un curso de formación de profesores, concretamente en lo que respecta a las prácticas de enseñanza y evaluación. Los datos fueron recolectados a través de grupos focales con 30 estudiantes inscritos en un curso en el área de docencia. Los resultados apuntan a la prevalencia de prácticas docentes más tradicionales y a la falta de articulación entre la teoría y la práctica, aunque también hay aspectos que hacen referencia a diferentes grados de implicación de los alumnos en las actividades del aula y a diferentes dinámicas de interacción entre profesores y alumnos. Aunque los participantes destacan la importancia de la diversidad de los métodos de evaluación, y algunos admiten la relevancia de los portafolios y la retroalimentación oportuna y pertinente, sobresale el predominio de los exámenes y el trabajo en grupo.
Design and Development of Hydraulically Operated Torx Key Manufacturing Machine
Authors: Patil Ratnadip , Hingole Dr. R. S. , Savale Mr. Nilesh , Ghuge Mr. Ritesh Dilip , Aandhale Mr. Dipak
Published: March 2022

Abstract: The scant documentation available indicates that the idea of a hex socket screw drive was probably conceived from the 1860s to the 1890s, but there were no such screw manufacturers till 1910. This Torx key is used to drive bolts and screws with hexagonal sockets in their heads. Torx is a type of screw drive characterized by a 6-point star-shaped pattern, developed in 196 by Camcar Textron. A popular name that is generic, for the drive is a star, as in star screwdriver or star bits. Torx key is used generally to unlock the Torx screws. This paper shows the Manufacturing of Torx key machine using a hydraulic system, its circuit design, and 3D modeling of the machine using Autocad Fusion 360. Keywords: Torx key, Mini Press, Hydraulic Press, Embossing dies.
OTT Platforms Usage of During Covid-19 Lockdown
Authors: Reddy Pothe Reddy Sai Kiran , Tajammul Mohd
Published: March 2022

Abstract: Digital digitalization has changed the way we access and use our content. Information is available at the click of a button and is always in our hands. The proliferation of the Internet led to the collapse of the planet, figuratively speaking. Content based on entertainment mixed with information (infotainment), unlike the latest news, tends to attract the attention of better audiences. The rise of OTT platforms, this trend has seen a new. Content from around the world is available without wasting much time. It would not be wrong to say that OTT platforms like Netflix, Amazon Prime Video etc. provide catalytic momentum in globalization. These forums can be commended for bringing the world together and bringing them closer together and for promoting a better sense of cultural understanding among the masses. During the tragic times of the unprecedented global epidemic such as COVID-19, these highly sought-after video platforms saw a dramatic increase in their visuals. As a result of the closure and the official social reduction practices adopted by many countries affected by the epidemic, people have registered for higher attendance at these forums. It is because of these methods and statistics of increasing popularity and reliance on OTT foundations of entertainment, information and engagement among viewers that this research has done. This urban youth survey aims to assess the tendency to use content during closure, to understand your causes and impacts. Keywords: OTT, Video-on-demand, digitization, infotainment, content, COVID-19 pandemic, lockdown.
Reconfigurable Manufacturing System: A Review
Authors: Kumar Vipin , Ramesan Sreeraj , Kumar Vipin , Madan Dr. A. K
Published: March 2022

Abstract: Manufacturing firms/companies in the twenty-first century might be compelled to manage unpredictably high-rate, high-risk market changes energized by overall market competitiveness. To remain competitive in the market, these businesses should put resources into flexible manufacturing solutions and new kinds of manufacturing systems that are both cost-effective and touchy to market changes without forfeiting product and production quality. Re-configurability is a recent fad in designing technology that spotlights cost-effective, fast responses to market changes. Reconfigurable manufacturing systems (RMS) are another manufacturing paradigm that accepts a framework that is more delicate to changing market demands, including components like reconfigurable machines and reconfigurable controllers, as well as approaches for their deliberate plan and fast increase. This paper gives a basic overview of reconfigurable manufacturing systems (RMS) and the objectives that satisfy this approach. Keywords: RMS (Reconfigurable Manufacturing System) and FMS (Flexible Manufacturing System).
Evaluation of effective factors on pain in patients undergoing sleep apnea surgery
Authors: Heidari Reihaneh , Najafzadeh Mahsa , Erfaniyan Reza , Razmpa Ebrahim , Emami Hamed , Heidari Matineh
Published: March 2022

Objectives: The aim of this study was to investigate the factors affecting postoperative pain.
Methods: This descriptive cross-sectional study was performed on patients referred to the hospital to determine the factors affecting postoperative pain for patients with obstructive sleep apnea (OSA). Patients' information was recorded: age, sex, weight, height, body mass index, duration of surgery, possible complications, and anesthesia. Patients were evaluated for pain according to VAS criteria. The first time a patient requested a drug was recorded in 24 hours after surgery and data was then analyzed.
Results: A total of 40 patients were enrolled in the study, including 14 women (35%) and 26 men (65%). The mean age of patients was 41.55 ± 7.43 years. Examination of the relationships between other variables with patients' pain intensity showed a statistically significant difference between patients' pain intensity with other variables such as history of stroke (P = 0.005), history of cardiovascular disease (P = 0.048), history of drug abuse (P = 0.046) and type of analgesia received after surgery (P = 0.032). In multivariate analysis of the studied data, no statistically significant relationship was found between any of the variables with the intensity of patients' postoperative pain. The variances of height, weight, body mass index, duration of surgery and the first time of application of analgesic after surgery did not differ in different groups of pain intensity variables. But a significant difference was found between the two variables of age and pain intensity of patients (P <0.05).
Conclusion: The results of this study showed a statistically significant difference in pain intensity with a history of stroke, cardiovascular disease, history of drug abuse and also the type of analgesia received after surgery. The serious complications caused by tolerating acute postoperative pain, especially the long-term effects of experiencing severe pain, necessitates more attention to pain control.
Modern Nanotechnology Application for Generation Highly Efficient Electricity in Save Mode and Much Less Polluting
Authors: HASAN Mohammed Flayyih , DANIŞMAZ Merdin , WAHEED Faez
Published: March 2022

Most world country dependent on foreign oil to make things working, which means political disputes or any disputes between countries can result in energy crunches. The negative changes that occur in the global climate and environment due to the burning of fossil fuels, stimulate the search for modern and environmentally friendly sources of energy production. In addition, continued concern about the storage and processing of nuclear waste may limit nuclear energy options. New concepts use nanotechnology as a new application for production of the electricity. In the modern thin-film application technologies, a number of layers can be deposited to improve the cells' energy density, reduce operating temperatures, and lower manufacturing costs. Solid oxide fuel cells (SOFCs), which have the ability to convert chemical energy into electrical energy without combustion, are among the advantages of this cell; High efficiency and much less pollution. Fuel cells - zinc, air, proton exchange membranes, and solid oxide are recent and established energy applications. Several of these solid oxide fuel cells (SOFCs) have emerged as fuel cell technology that has additional positive advantages.
Quantifying dominant bacterial genera detected in metagenomic data from fish eggs and larvae using genus-specific primers
Authors: Najafpour Babak , Pinto Patricia , Canario Adelino , Power Deborah
Published: March 2022

The goal of this study was to design genus-specific primers for rapid
evaluation of the most abundant bacterial genera identified using
amplicon-based sequencing of the 16S rRNA gene in fish-related samples
and surrounding water. Efficient genus-specific primers were designed
for eleven bacterial genera including Alkalimarinus, Colwellia,
Enterovibrio, Marinomonas, Massilia, Oleispira, Phaeobacter,
Photobacterium, Polarbacerium, Pseudomonas, and Psychrobium. The
specificity of the primers was confirmed by the phylogeny of the
sequenced polymerase chain reaction (PCR) amplicons that indicated
primers were genus-specific except in the case of Colwellia and
Phaeobacter. Copy number of the 16S rRNA gene obtained by quantitative
PCR using genus-specific primers and the relative abundance obtained by
16S rRNA gene sequencing using universal primers were well correlated
for the five analyzed abundant bacterial genera. Low correlations
between quantitative PCR and 16S rRNA gene sequencing for Pseudomonas
were explained by the higher coverage of known Pseudomonas species by
the designed genus-specific primers than the universal primers used in
16S rRNA gene sequencing. The designed genus-specific primers are
proposed as rapid and cost-effective tools to evaluate the most abundant
bacterial genera in fish-related or potentially other metagenomics
samples.
THE APPLICATION OF COMPUTER VISION FOR SCANNING THE BLADE EDGE DURING REPAIR PROCEDURES
Authors: KOTLYAR DMITRY I. , LOMANOV ALEXEY N. , KORNEYCHUK VALERY S.
Published: March 2022

The authors consider common techniques for scanning the blade edge during repair procedures in aerospace industry using additive technologies. The article describes common 3D scanning techniques, their pros and cons. The authors focus on the improved algorithm for scanning the blade edge based on the phase-shift method and computer vision system integrated with a work tool.
DETERMINING THE PRIORITY OF CRITERIA IN THE OPTIMIZATION PROBLEM OF SELECTING CHARGE MATERIALS FOR AN ELECTRIC FURNACE
Authors: LOGUNOVA OKSANA S. , SIBILEVA NATALIA S.
Published: March 2022

He aim of the study is to build an algorithm for determining the priority of criteria in the optimization problem of selecting the charge materials for an electric arc furnace. The problem being solved is to provide the charge in the form of a mixture, in which each element introduces a predetermined amount of chemical elements that are difficult to remove during melting. The requirements for the content of these elements are determined by several target functions. When solving the problem, it becomes necessary to prioritize achieving the goal according to the importance of each criterion. In this work, the authors provided an algorithm for choosing the preference of criteria and demonstrated its functioning using the example of three criteria for minimizing the amount of residual elements of chromium, nickel and copper when melting steel in an electric arc furnace. The main stages of work are: classification of requirements for the quality of charge materials; formalization of the criteria list; algorithm development for formalizing the problem of choosing charge materials; methodology development for determining preferences among three criteria. The criteria are ranked with reference to expert assessments. An assessment of the experts’ competence has been carried out applying the algorithm of L. G. Evlanov and V. A. Kutuzov, which shows equal experts’ competence at various iterations. As a result of the study, the authors provided a list of criteria for the mathematical support of multicriteria optimization when forming the structure of charge materials for an electric arc furnace. This makes it possible to bring the problem to a single-criterion kind and apply the appropriate solution methods.
Ledare vol. 11 nr. 3 2021
Authors: Jers Cecilia Olsson , Lindberg-Sand Åsa
Published: March 2022

Mitt i sommaren det märkliga pandemi-året 2021 firade Högre utbildning sitt tioårsjubileum. Vi firade på distans genom att utlysa ett särskilt tema om vad Covid-19 pandemin med övergång till distansutbildning och arbetet hemifrån inneburit för högre utbildning. Vi fick in mer än tjugo bidrag. Det första av dessa ingår i det här numret och presenteras nedan. Under 2022 kommer flera artiklar på temat.
Ovarian Ectopic Gestation after Assisted Reproductive Technique with Intracytoplasmic Sperm Insemination
Authors: Kubaisi Muna Kh. Al , Yusoff Md Azam Md , Al-Shibli Saad M. , Ismail Nurul Jannah , Md Ibrahim Iza Emilia , Azizan Azha S. , Affandi KA Affandi Khairunisa Ahmad , Ramli Roszaman
Published: March 2022

Assisted reproduction technique (ART) is a known risk factor for ectopic pregnancy (EP). Ovarian ectopic pregnancy (OEP) is a rare but well-known variant of EP, which carries diagnostic challenges & is mostly diagnosed intraoperatively. Fibroid is a common medical problem, but it is not yet a recognised risk factor for OEP. Risk factors as pelvic inflammatory disease, endometriosis or fibroids can alter fallopian tube patency results in EP. In this case study the embryo implantation occurs in the ovaries with retrograde embryo migration from the uterine cavity to the peritoneum. We present an OEP with male factor subfertility that went for frozen embryo transfer. The woman had multiple small fibroids referred to the tertiary centre for fluctuation in β-hCG level and suspicion of cornual pregnancy. However, the patient was asymptomatic & haemodynamically stable. Initial diagnosis of EP with viable fetus necessitate laparoscopic interference revealed left sided OEP with normal left fallopian tube (FT). The right ovary and FT looked normal. Surgical interference with partial oophorectomy was done and the histopathological report confirms the diagnosis of OEP. The following embryo transfer after 3 months ended by viable intrauterine pregnancy.
Association of Extracranial Carotid Artery Stenosis in Ischemic Stroke in a Sri Lankan Cohort of Patients - An Analytical Cross-Sectional Study
Authors: Rajapakshe (MBBS, MD, MRCP) Ishani , Wijesundara (MBBS) Devasmitha , Chandrakumara (MBBS, MD) Amila , Senanayake (MBBS, MD, FRCP, FCCP) Bimsara
Published: March 2022

Background and Objectives: The burden of stroke in Sri Lanka is on the increase with the current demographic transition toward an ageing population. However, the association of symptomatic extracranial carotid artery stenosis (CAS) in ischemic stroke has not been prospectively evaluated in a Sri Lankan cohort of ischemic stroke patients. Globally population-based studies have estimated about 15% of ischemic strokes are caused by large vessel occlusions. It is commonly believed that the prevalence of significant extracranial CAS is low in Sri Lanka compared to western populations. The purpose our study is to systematically analyses and assess this long held notion and to search for other associated causative factors. Methods: The study population comprised of 164 acute ischemic stroke patients admitted consecutively to the National hospital of Sri Lanka over a period of 3 months. Carotid artery duplex scans were done by a single well-trained operator within 2 weeks of presentation and degree of CAS was classified as low (<50%), moderate (50-69%), severe (>70%) and complete occlusion according to NASCET criteria. Factors associated with CAS were identified by stepwise multiple logistic regression analysis. Results: Out of 164 ischemic stroke patients 104 (63.4%) were male and 60 (36.6%) were female. The mean age of stroke patients was 62.2+- 14.21 years. 139 (84.8%) had low grade stenosis, 10 (6.1%) had moderate stenosis, 7 (4.2%) had severe stenosis and 8 (4.9 %) had complete stenosis of carotid artery. Older age and presence of previous TIAs were significantly associated with CAS. Gender, hypertension, diabetes mellitus, hypercholesterolemia, IHD, previous stroke, previous TIA, previous use of antiplatelets, family history of stroke, previous use of statins and presence of carotid bruit were not significantly associated. Conclusion: Extracranial carotid artery occlusion previously considered a rare cause of ischemic stroke in Sri Lanka was found to be having prevalence similar to western populations in this study with over 15% having significant stenosis. Hence, we emphasize that early carotid doppler studies must be performed in all ischemic strokes at least within two weeks and necessary interventions carried out where it is deemed necessary.
Formulasi Masker Gel Peel-Off Berbahan Ekstrak Biji Kopi Robusta (Coffea canephora) Khas Lampung
Authors: Yasir Angga Saputra , Suryaneta Suryaneta , Fahmi Achmad Gus , Saputra Iwan Syahjoko , Hermawan Dessy , Berliyanti Rery Tri
Published: March 2022

Kopi robusta (Coffea canephora) merupakan salah satu komoditas unggulan yang berada di Provinsi Lampung. Selain sebagai olahan minuman, biji kopi robusta juga dapat dimanfaatkan sebagai bahan tambahan alami dalam sediaan produk kosmetik. Masker gel peel-off merupakan salah satu jenis produk kosmetik yang dapat berfungsi sebagai anti-aging pada wajah. Pada penelitian ini, formulasi masker gel peel-off berhasil dipreparasi dengan memanfaatkan ekstrak biji kopi robusta. Metode formulasi masker gel peel-off dilakukan melalui proses in-situ. Hasil uji fitokimia menunjukkan senyawa metabolit sekunder yang terkandung dalam ekstrak biji kopi robusta yaitu alkaloid, flavonoid, saponin, dan tannin. Analisis spektrofotometer UV-vis menunjukkan kadar senyawa flavonoid sebesar 5,86 mg/g. Hasil uji pH masker gel peel-off menggunakan ekstrak kopi robusta sebesar 5,3. Masker gel peel-off tidak menyebabkan reaksi iritasi pada kulit. Sifat fisik dari masker gel peel-off terlihat berwarna coklat dengan bentuk semisolid. Hasil uji aktivitas antioksidan masker gel peel-off menunjukkan nilai IC50 sebesar 7,104 ppm. Dari data yang ada dapat disimpulkan bahwa senyawa flavonoid dalam ekstrak biji kopi robusta sangat berpengaruh terhadap aktivitas antioksidan dalam formulasi sediaan masker gel peel-off.
A Framework for Verification in Contactless Secure Physical Access Control and Authentication Systems
Authors: Mwangi Boniface
Published: March 2022

Biometrics is one of the very popular techniques in user identification for accessing institutions and logging into attendance systems. Currently, some of the existing biometric techniques such as the use of fingerprints are unpopular due to COVID-19 challenges. This paper identifies the components of a framework for secure contactless access authentication. The researcher selected 50 journals from Google scholar which were used to analyze the various components used in a secure contactless access authentication framework. The methodology used for research was based on the scientific approach of research methodology that mainly includes data collection from the 50 selected journals, analysis of the data and assessment of results. The following components were identified: database, sensor camera, feature extraction methods, matching and decision algorithm. Out of the considered journals the most used is CASIA database at 40%, CCD Sensor camera with 56%, Gabor feature extraction method at 44%, Hamming distance for matching at 100% and PCA at 100% was used for decision making. These findings will assist the researcher in providing a guide on the best suitable components. Various researchers have proposed an improvement in the current security systems due to integrity and security problems.
Review of Semantic Importance and Role of using Ontologies in Web Information Retrieval Techniques
Authors: Ali Ashraf
Published: March 2022

The Web contains an enormous amount of information, which is managed to accumulate, researched, and regularly used by many users. The nature of the Web is multilingual and growing very fast with its diverse nature of data including unstructured or semi-structured data such as Websites, texts, journals, and files. Obtaining critical relevant data from such vast data with its diverse nature has been a monotonous and challenging task. Simple key phrase data gathering systems rely heavily on statistics, resulting in a word incompatibility problem related to a specific word's inescapable semantic and situation variants. As a result, there is an urgent need to arrange such colossal data systematically to find out the relevant information that can be quickly analyzed and fulfill the users' needs in the relevant context. Over the years ontologies are widely used in the semantic Web to contain unorganized information systematic and structured manner. Still, they have also significantly enhanced the efficiency of various information recovery approaches. Ontological information gathering systems recover files focused on the semantic relation of the search request and the searchable information. This paper examines contemporary ontology-based information extraction techniques for texts, interactive media, and multilingual data types. Moreover, the study tried to compare and classify the most significant developments utilized in the search and retrieval techniques and their major disadvantages and benefits.
Glycosylated stigmasterol from the rind of Napoleonaea imperialis
Authors: Ndukwe Gloria Ihuoma , Jack Ibiba Reuben , Ekong Rachael Elijah
Published: March 2022

Napoleonaea imperialis rinds were separated from the seeds and extracted via maceration using methanol. The crude methanol extract was partitioned with n-hexane and dichloromethane to yield n-hexane fraction (11.01 g), dichloromethane fraction (35.16 g) and methanol fraction (101.75 g). Dichloromethane fraction was chromatographed and purified to give a compound whose structure was elucidated using one-dimension and two-dimension nuclear magnetic resonance (NMR) experiments. The isolated compound was characterized as glycosylated stigmasterol.
Calcium Oxalate Crystal Yield in Various Gravity Environments
Authors: Egusquiza Riann J. , Runyon Robert Benjamin , Ringel Jordan , Seber Craig W.C. , Leyva Gonzalo , Correa Jose , Roland Coulibaly Datoliban , Umar Mujahid , Xiao Ming , Bushoven John T. , Goto Joy J.
Published: March 2022

An experimental chamber and hand-manipulated syringe apparatus were designed, tested, and utilized to assess calcium oxalate crystal yield in Terrestrial-g (1 g), micro-g (0.01 g), Lunar-g (0.16 g), and Martian-g (0.38 g). Aqueous solutions of calcium chloride (100 mM) and oxalic acid (200 mM) were mixed to precipitate calcium oxalate crystals. Gravitational differences were hypothesized to result in differences in the yield of crystal formation. These data are essential for efforts to better understand the correlation between calcium oxalate crystal formation and the production of kidney stones often associated with long-term space missions. The analyses of crystal formation produced in the micro-g (≅0.01 g) conditions of this study suggest that calcium oxalate monohydrate formation yield is slightly greater than those produced in Terrestrial-g conditions.