bluuebunny/crossref_metadata_2025 huggingface dataset:
Rediscovery of the holotypes of Mustela africana stolzmanni Taczanowski, 1881 (Carnivora: Mustelidae) and Cuniculus taczanowskii Stolzmann, 1885 (Rodentia: Cuniculidae) at the Museum and Institute of Zoology Polish Academy of Sciences in Warsaw, Poland
Authors: PIECHNIK ŁUKASZ , MIERZWA-SZYMKOWIAK DOMINIKA , KUREK PRZEMYSŁAW
Published: August 2017

The turbulent history of Warsaw resulted in great losses in Polish zoological museums and archives especially during First and Second World War (Kazubski 1996; Fedorowicz & Feliksiak 2016). However, before 1939 Warsaw’s zoological collection deposited in the State Zoological Museum (now called: the Museum and Institute of Zoology Polish Academy of Sciences in Warsaw—MIZ PAS), especially the department of neotropics, used to be one of the best developed and well cataloged collections in Europe. There were also many holotypes of mammal species stored here after Polish expeditions to the neotropics. As a result of these events current bibliography and on-line databases (GBIF, VertNet) up to now did not mention the location of holotypes of collected taxa or even recognize them as missing (Ramírez-Chavez et al. 2014; Patton et al. 2015). We reviewed the collection to estimate the presence and status of the surviving descriptive types (holotypes). The aim of this study was to order our knowledge about the holotypes taking into account especially information about lost specimens and to explain the contradictory information about their status in the present. In 2015–2016 all type specimens in the MIZ PAS collection of neotropical mammals were revised. During revision relevant information from specimen labels was compared with the data provided in the original descriptions contained in publications from the end of nineteenth century (Taczanowski 1881; Thomas 1884; Stolzmann 1885; Thomas 1893; 1894). The results were compared with the collection databases of the Natural History Museum in London (http://data.nhm.ac.uk). Systematics and species nomenclature were followed by Wilson & Reeder (2005). Zoological nomenclature types were followed by International Commission on Zoological Nomenclature (ICZN). The results of the revision are presented as a systematic list.
Local Characteristics of the Nocturnal Boundary Layer in Response to External Pressure Forcing
Authors: van der Linden Steven J. A. , Baas Peter , Antoon van Hooft J. , van Hooijdonk Ivo G. S. , Bosveld Fred C. , van de Wiel Bas J. H.
Published: August 2017

Geostrophic wind speed data, derived from pressure observations, are used in combination with tower measurements to investigate the nocturnal stable boundary layer at Cabauw, the Netherlands. Since the geostrophic wind speed is not directly influenced by local nocturnal stability, it may be regarded as an external forcing parameter of the nocturnal stable boundary layer. This is in contrast to local parameters such as in situ wind speed, the Monin–Obukhov stability parameter (z/L), or the local Richardson number. To characterize the stable boundary layer, ensemble averages of clear-sky nights with similar geostrophic wind speeds are formed. In this manner, the mean dynamical behavior of near-surface turbulent characteristics and composite profiles of wind and temperature are systematically investigated. The classification is found to result in a gradual ordering of the diagnosed variables in terms of the geostrophic wind speed. In an ensemble sense the transition from the weakly stable to very stable boundary layer is more gradual than expected. Interestingly, for very weak geostrophic winds, turbulent activity is found to be negligibly small while the resulting boundary cooling stays finite. Realistic numerical simulations for those cases should therefore have a comprehensive description of other thermodynamic processes such as soil heat conduction and radiative transfer.
Endothelial Cell Inflammation and Antioxidant Capacity are Associated With 6-Minute Walk Performance in Patients With Symptomatic Peripheral Artery Disease
Authors: Gardner Andrew W. , Montgomery Polly S. , Zhao Yan D. , Ungvari Zoltan , Csiszar Anna , Sonntag William E.
Published: August 2017

We determined whether 6-minute walk total distance and pain-free distance were associated with circulating biomarkers of antioxidant capacity and inflammation and with cultured endothelial cell inflammation, oxidative stress, and apoptosis in 251 patients with symptomatic peripheral artery disease (PAD). In multivariate analyses, pain-free distance during the 6-minute walk test was negatively associated with dyslipidemia ( P < .001), chronic kidney disease ( P = .004), and transient transfection, nuclear factor κ-Light-Chain-Enhancer of activated B (NF-κB) cultured endothelial cells ( P = .007) and was positively associated with height ( P = .008). Furthermore, total distance walked during the 6-minute walk test was negatively associated with cultured endothelial cell NF-κB ( P < .001), coronary artery disease ( P = .009), and body mass index ( P = .022) and was positively associated with ankle–brachial index ( P < .001), male sex ( P < .001), and hydroxyl radical antioxidant capacity ( P < .001). The 6-minute walk performance in symptomatic patients with PAD was associated with vascular biomarkers, as walking distances were negatively associated with cultured endothelial cell inflammation and positively associated with circulating antioxidant capacity. The clinical implication is that behavioral interventions designed to alleviate endothelial cell inflammation and increase circulating antioxidant capacity, such as exercise and antioxidant intake, may improve ambulation of patients with PAD during submaximal exercise that is typically performed during daily activities.
Searching for prohibited items in mental-health hospitals: A randomised controlled trial of two metal-detecting technologies
Authors: Laidlaw James , Dix Roland , Slack Philip , Foy Chris , Hayward Andy , Metherall Alan , Ireland Steve , Wright James , O’Rourke Paul , Williams Jon , Rose Anneka
Published: August 2017

Weapons and other items with potential to cause harm are usually prohibited in mental-health hospitals and other psychiatric facilities. Detecting such prohibited items (PIs) can be problematic, particularly if concealed, and metal detectors are commonly used to search for such items. Our study compared two types of metal detection: continuous wave detection (CWD) by hand-held metal detector (HHMD) and magnetic anomaly detection (MAD) by a static pole device. In the study, real and dummy PIs were hidden on test subjects and in a simulated body cavity. The results showed MAD to be significantly superior to CWD in detecting small concealed PIs containing ferrous metal. The MAD pole found 100% of the real PIs on the test subjects and in the simulated body cavity. The CWD HHMD found only 5.2% of the real PIs, and these were limited to those on the test subjects, as it detected none in the simulated body cavity. In addition, the time taken to search by MAD pole was shorter than time taken to search by CWD HHMD.
Delays in diagnosis are associated with poorer outcomes in adult hip dysplasia
Authors: Kennedy John W , Brydone Alistair S , Meek Dominic RM , Patil Sanjeev R
Published: August 2017

Background and Aims

Developmental dysplasia of the hip is a common cause of osteoarthritis. Periacetabular osteotomy can restore femoral head coverage; however, it is reserved for patients with minimal articular degeneration. We examined the relationship between delays in diagnosis and outcomes.

Methods

We identified patients presenting to a hip specialist with a new diagnosis of hip dysplasia. The time taken between patients presenting to their general practitioner and attending the young adult hip clinic was established. Patients were stratified into Early, Moderate and Late Referral groups. Hip and SF-12 questionnaires were completed. Radiographs were graded according to the Tönnis classification system and the outcome following hip specialist review documented.

Results

Fifty-one patients were identified. Mean time from attending a general practitioner to review at the young adult hip clinic was 40.4 months. Lower hip and SF-12 scores, and higher radiological osteoarthritis grades were found in the Moderate and Late Referral groups. A higher proportion of the Moderate and Late Referral group underwent total hip arthroplasty rather than periacetabular osteotomy.

Conclusion

Delays in referring a patient to a hip specialist are associated with poorer outcomes. We propose pelvic radiographs are requested early by general practitioners to allow prompt diagnosis and referral to a hip specialist.
Diagnostic value of apparent diffusion coefficient in differentiating between high-grade gliomas and brain metastases
Authors: Caravan Ionut , Ciortea Cristiana Augusta , Contis Alexandra , Lebovici Andrei
Published: August 2017

Background

High-grade gliomas (HGGs) and brain metastases (BMs) can display similar imaging characteristics on conventional MRI. In HGGs, the peritumoral edema may be infiltrated by the malignant cells, which was not observed in BMs.

Purpose

To determine whether the apparent diffusion coefficient values could differentiate HGGs from BMs.

Material and Methods

Fifty-seven patients underwent conventional magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) before treatment. The minimum and mean ADC in the enhancing tumor (ADCmin, ADCmean) and the minimum ADC in the peritumoral region (ADCedema) were measured from ADC maps. To determine whether there was a statistical difference between groups, ADC values were compared. A receiver operating characteristic (ROC) curve analysis was used to determine the cutoff ADC value for distinguishing between HGGs and BMs.

Results

The mean ADCmin values in the intratumoral regions of HGGs were significantly higher than those in BMs. No differences were observed between groups regarding ADCmean values. The mean ADCmin values in the peritumoral edema of HGGs were significantly lower than those in BMs. According to ROC curve analysis, a cutoff value of 1.332 × 10−3 mm2/s for the ADCedema generated the best combination of sensitivity (95%) and specificity (84%) for distinguishing between HGGs and BMs. The same value showed a sensitivity of 95.6% and a specificity of 100% for distinguishing between GBMs and BMs.

Conclusion

ADC values from DWI were found to distinguish between HGGs and solitary BMs. The peritumoral ADC values are better than the intratumoral ADC values in predicting the tumor type.
Molecular microdeletion analysis of infertile men with karyotypic Y chromosome abnormalities
Authors: Pan Yuan , Zhang Hong-guo , Xi QI , Zhang Han , Wang Rui-xue , Li Lei-lei , Liu Rui-zhi
Published: August 2017

Objectives

To investigate azoospermic factor (AZF) microdeletions in infertile men from northeastern China with karyotypic Y chromosome abnormalities.

Methods

G-banding of metaphase chromosomes and karyotype analysis were performed in all infertile male patients. Genomic DNA was isolated and used to analyze classical AZF microdeletions by PCR. The regions and sequence-tagged sites of AZFa (SY86, SY84), AZFb (SY127, SY134, SY143), and AZFc (SY152, SY254, SY255, SY157) were sequenced by multiplex PCR.

Results

A total of 190 Y chromosome abnormality carriers were found, of whom 35 had AZF microdeletions. These were most common in 46,X,Yqh− patients, followed by 45,X/46,XY patients. Most microdeletions were detected in the AZFb + c region, including 48.57% of all AZF microdeletion cases. AZF partial deletions were also seen in these patients. Overall, AZF microdeletions were detected in 38.5% Y chromosome abnormality carriers, and most were observed in 46,X,Yqh− individuals. Loss of SY152 was seen in all 35 patients, with SY254/SY255 detected in 34 of 35 patients.

Conclusions

AZF microdeletions were detected in 38.5% of Y chromosome abnormality carriers. This indicates that AZF microdeletion screening is advisable for individuals with karyotypic Y chromosome abnormalities.
Comparative effects of traditional Chinese and Western migraine medicines in an animal model of nociceptive trigeminovascular activation
Authors: Zhao Yonglie , Martins-Oliveira Margarida , Akerman Simon , Goadsby Peter J
Published: August 2017

Background

Migraine is a highly prevalent and disabling disorder of the brain with limited therapeutic options, particularly for preventive treatment. There is a need to identify novel targets and test their potential efficacy in relevant preclinical migraine models. Traditional Chinese medicines have been used for millennia and may offer avenues for exploration.

Methods

We evaluated two traditional Chinese medicines, gastrodin and ligustrazine, and compared them to two Western approaches with propranolol and levetiracetam, one effective and one ineffective, in an established in vivo rodent model of nociceptive durovascular trigeminal activation.

Results

Intravenous gastrodin (30 and 100 mg/kg) significantly inhibited nociceptive dural-evoked neuronal firing in the trigeminocervical complex. Ligustrazine (10 mg/kg) and propranolol (3 mg/kg) also significantly inhibited dural-evoked trigeminocervical complex responses, although the timing of responses of ligustrazine does not match its pharmacokinetic profile. Levetiracetam had no effects on trigeminovascular responses.

Conclusion

Our data suggest gastrodin has potential as an anti-migraine treatment, whereas ligustrazine seems less promising. Interestingly, in line with clinical trial data, propranolol was effective and levetiracetam not. Exploration of the mechanisms and modelling effects of Chinese traditional therapies offers novel route for drug discovery in migraine.
Survival forests for data with dependent censoring
Authors: Moradian Hoora , Larocque Denis , Bellavance François
Published: August 2017

Tree-based methods are very powerful and popular tools for analysing survival data with right-censoring. The existing methods assume that the true time-to-event and the censoring times are independent given the covariates. We propose different ways to build survival forests when dependent censoring is suspected, by using an appropriate estimator of the survival function when aggregating the individual trees and/or by modifying the splitting rule. The appropriate estimator used in this paper is the copula-graphic estimator. We also propose a new method for building survival forests, called p-forest, that may be used not only when dependent censoring is suspected, but also as a new survival forest method in general. The results from a simulation study indicate that these modifications improve greatly the estimation of the survival function in situations of dependent censoring. A real data example illustrates how the proposed methods can be used to perform a sensitivity analysis.
Adjacent Joint Kinematics After Ankle Arthrodesis During Cadaveric Gait Simulation
Authors: Sturnick Daniel R. , Demetracopoulos Constantine A. , Ellis Scott J. , Queen Robin M. , Kolstov Jayme C. B. , Deland Jonathan T. , Baxter Josh R.
Published: August 2017

Background:

Arthrodesis is an effective and reliable treatment for end-stage ankle arthritis; however, many patients develop ipsilateral adjacent joint arthritis following surgery. The mechanism that drives adjacent joint arthritis remains uncertain. Cadaveric simulation permits direct investigation of the effects of both arthrodesis and movement strategy on adjacent joints during simulated walking. The objective of this study was to identify the isolated effect of ankle arthrodesis on adjacent joint kinematics during simulated walking.

Methods:

Effects of ankle arthrodesis on adjacent joint kinematics were assessed in 8 cadaveric foot and ankle specimens using a robotic gait simulator. Gait parameters acquired from healthy adults and patients with ankle arthrodesis were used as inputs for simulations. Three-dimensional subtalar and talonavicular joint kinematics were directly measured before and after ankle arthrodesis, and healthy- and arthrodesis-gait parameters were applied to identify the isolated effect of the ankle arthrodesis on adjacent joint kinematics.

Results:

Ankle arthrodesis increased subtalar and talonavicular joint motion during early and midstance independent of which gait parameters were used as inputs to the gait simulator. However, adjacent joint motions did not differ between the control and arthrodesis condition during late stance, when the healthy gait parameters were used as inputs. Conversely, adjacent joint motion decreased during late stance following arthrodesis when simulating gait using parameters typical in arthrodesis patients.

Conclusions:

Regardless of the gait parameter inputs, subtalar and talonavicular joint motions increased from normal kinematics, which likely increase the biomechanical burden placed on these adjacent joints and may lead to joint degeneration.

Clinical Relevance:

Increased motion of the adjacent joints caused by ankle arthrodesis may explain the articular degeneration observed clinically.
Crowdsourcing obituaries in the digital age: ABC Open’s In Memory Of
Authors: Graham Pamela
Published: August 2017

This article considers the evolution of the traditionally exclusive, biographical form of the obituary as it migrates online. ABC Open’s In Memory Of is an online crowdsourced project that consists of obituaries written by and about ‘ordinary Australians’. Through an examination of the most, and least, popular profiles on the site, a number of significant trends emerge. The participatory, social media platform of In Memory Of encourages commemorative writing that is more confessional and personal than many traditional obituaries, and, in turn, this intimacy promotes affective responses from visitors to the site. The obituaries highlight and reconfirm the continuing, and important, social role of online memorials: their capacity to be educational or therapeutic spaces. In addition, the In Memory Of profiles function as cultural sites that reveal common anxieties about ways of dying, and, in doing so, articulate a symbolism associated with particular forms of death.
Beneficial effect of statins on total mortality in abdominal aortic aneurysm (AAA) repair
Authors: Mathisen Sven Ross , Abdelnoor Michael
Published: August 2017

In this single center, retrospective cohort study we wished to compare early and total mortality for all patients treated for abdominal aortic aneurysms (AAA) with open surgery who were taking statins compared to those who were not. A cohort of 640 patients with AAA was treated with open surgery between 1999 and 2012. Patients were consecutively recruited from a source population of 390,000; 21.3% were female, and the median age was 73 years. The median follow-up was 3.93 years, with an interquartile range of 1.79–6.58 years. The total follow-up was 2855 patient-years. An explanatory strategy was used. The propensity score (PS) was implemented to control for selection bias and confounders. The crude effect of statin use showed a 78% reduction of the 30-day mortality. A stratified analysis using the Mantel–Haenszel method on quintiles of the PS gave an adjusted effect of the odds ratio equal to 0.43 (95% CI: 0.18–0.96), indicating a 57% reduction of the 30-day mortality for statin users. The adjusted rate ratio was 0.62 (95% CI: 0.45–0.83), indicating a reduction of long-term mortality of 38% for statin users compared to non-users for a median follow-up of 3.93 years. This retrospective cohort study showed a significant beneficial effect of statin use on early and long-term survival for patients treated with open surgery. To be conclusive, our results need to be replicated by a randomized clinical trial.
The applicability of official professionalism recommendations in the emergency department
Authors: Jahanshir Amirhosein , Motahar Hojat S , Saeedi Morteza , Vahidi Elnaz
Published: August 2017

In this cross-sectional observational study, we wanted to assess the viewpoints of residents and medical students about applicability of official professionalism recommendations in the emergency department. We asked 72 participants (24 medical students and 48 residents [29 PGY1 and 19 PGY2/3]) to fill a questionnaire, which was designed based on “the directory of professional ethics for physicians” written by Tehran University of Medical Sciences. The questionnaire consisted of 74 statements divided into 6 different categories: altruism, honor and integrity, justice, respect, duty and responsibility, and excellence. The mean and median of responses in PGY1 group were significantly more than PGY2/3 and medical students. These rates were nearly the same between PGY2/3 and medical student groups. We concluded that in a chaotic environment like the emergency department, it is important to know whether healthcare providers believe in the applicability of any professionalism recommendations or not. Our recommendation is that to ask the target group’s opinion before implementation of any new professionalism recommendations, because the unique situation of a work place can change the attitude of the trainees toward the applicability of recommendations.
Decoupling the Labeling Tradition
Authors: Caudill Jonathan W. , Diamond Brie , Karas Stephanie , DeLisi Matt
Published: August 2017

Scholars have tested Becker’s master status thesis on criminal justice system outcomes, yet have been unable to disentangle the label from behavioral characteristics. To clarify the effects of labels, we used archival juvenile court data to test Becker’s master status through the effects of gang affiliation on case disposition. Stratified multivariate regression models revealed consistent effects of predictors—mental health needs, offenses per case, felony offense, and pretrial detention—on case referral to juvenile court across the gang-affiliated demarcation. The static effects of legal predictors across the gang demarcation levy questions about the legal consequences of labels.
A nationwide analysis of 30-day readmissions related to critical limb ischemia
Authors: Masoomi Reza , Shah Zubair , Quint Clay , Hance Kirk , Vamanan Karthik , Prasad Anand , Hoel Andrew , Dawn Buddhadeb , Gupta Kamal
Published: August 2017

Objectives

There is paucity of information regarding critical limb ischemia-related readmission rates in patients admitted with critical limb ischemia. We studied 30-day critical limb ischemia-related readmission rate, its predictors, and clinical outcomes using a nationwide real-world dataset.

Methods

We did a secondary analysis of the 2013 Nationwide Readmissions Database. We included all patients with a primary diagnosis of extremity rest pain, ulceration, and gangrene secondary to peripheral arterial disease. From this group, all patients readmitted with similar diagnosis within 30 days were recorded.

Results

Of the total 25,111 index hospitalization for critical limb ischemia, 1270 (5%) were readmitted with a primary diagnosis of critical limb ischemia within 30 days. The readmission rate was highest (9.5%) for the group that did not have any intervention (revascularization or major amputation) and was lowest for surgical revascularization and major amputation groups (2.6% and 1.3%, P value <0.001 for all groups). Severity of critical limb ischemia at index admission was associated with a significantly higher rate of 30-day readmission. Critical limb ischemia-related readmission was associated with a higher rate of major amputation (29.6% vs. 16.2%, P<0.001), a lower rate of any revascularization procedure (46% vs. 62.6%, P<0.001), and a higher likelihood of discharge to a skilled nursing facility (43.2% vs. 32.2%, P<0.001) compared to index hospitalization.

Conclusions

In patients with primary diagnosis of critical limb ischemia, 30-day critical limb ischemia-related readmission rate was affected by initial management strategy and the severity of critical limb ischemia. Readmission was associated with a significantly higher rate of amputation, increased length of stay, and a more frequent discharge to an alternate care facility than index admission and thus may serve as a useful quality of care metric in critical limb ischemia patients.
Analysis of a training mesocycle and positional quantification in elite European soccer players
Authors: Owen Adam L , Lago-Peñas Carlos , Gómez Miguel-Ángel , Mendes Bruno , Dellal Alexandre
Published: August 2017

Ensuring adequate levels of training and recovery at the elite level of professional soccer to maximise player performance has continued to drive the necessity to monitor the training load and physical training output of soccer players. The aim of this investigation was to analyse a training mesocycle whilst quantifying positional demands imposed on elite European soccer players. Sixteen players were assessed using global positioning systems and ratings of perceived exertion over a competitive training six-week mesocycle period. The positional demands and training loads were analysed in addition to match conditions (match location, match score) and player’s age. Results from the investigation revealed that typical daily training loads (i.e. total distance, high-intensity distance, sprint distance, average speed, ratings of perceived exertion) did not differ throughout each week of the mesocycle in-season period. Further analysis revealed training loads were significantly lower on match day-1 when compared to training loads on match day-2, match day-3 and match day-4 preceding a match ( p < 0.05). Significant differences in physical outputs were also found between match day-2, match day-3 and match day-4 highlighting a structured periodised tapered approach ( p < 0.05). Lower average speeds were reported in training post-successful matches compared to defeats ( p < 0.05), and more specifically when a match was played away compared to home fixtures ( p < 0.05). To conclude, practitioners can maintain a uniformed and structured training load mesocycle whilst inducing variation of the physical outputs during the microcycle phase. Additionally, the investigation also provides a tapering approach that may induce significant variation of the positional demands.
The promise to the Arab World: Attributes of U.S. President Obama in Arabic-language tweets
Authors: Alkazemi Mariam F , Fahmy Shahira , Wanta Wayne
Published: August 2017

U.S. President Barack Obama's much-anticipated address in Egypt in 2009 promised a new beginning between the U.S. government and the Arab world but only a few years later there were many criticisms that the U.S. President did not live up to his promises, driving Arab attitudes toward the United States to their lowest point in years. Five years later, we analyzed Arabic-language twitter messages involving President Obama to examine cognitive and affective attributes. Results show that tweets by members of the media differed greatly from tweets by members of the public. The public tweets held more negative attitudes towards the U.S. President than tweets by news organizations. Members of the public also were more likely to link the President to a wider range of countries, suggesting a greater diversity of attributes, while primarily fixating on the Palestinian issue.
Phase 1 clinical trial using mbIL21 ex vivo–expanded donor-derived NK cells after haploidentical transplantation
Authors: Ciurea Stefan O. , Schafer Jolie R. , Bassett Roland , Denman Cecele J. , Cao Kai , Willis Dana , Rondon Gabriela , Chen Julianne , Soebbing Doris , Kaur Indreshpal , Gulbis Alison , Ahmed Sairah , Rezvani Katayoun , Shpall Elizabeth J. , Lee Dean A. , Champlin Richard E.
Published: August 2017

Relapse has emerged as the most important cause of treatment failure after allogeneic hematopoietic stem cell transplantation (HSCT). To test the hypothesis that natural killer (NK) cells can decrease the risk of leukemia relapse, we initiated a phase 1 dose-escalation study of membrane-bound interleukin 21 (mbIL21) expanded donor NK cells infused before and after haploidentical HSCT for high-risk myeloid malignancies. The goals were to determine the safety, feasibility, and maximum tolerated dose. Patients received a melphalan-based reduced-intensity conditioning regimen and posttransplant cyclophosphamide-based graft-versus-host disease (GVHD) prophylaxis. NK cells were infused on days −2, +7, and +28 posttransplant. All NK expansions achieved the required cell number, and 11 of 13 patients enrolled received all 3 planned NK-cell doses (1 × 105/kg to 1 × 108/kg per dose). No infusional reactions or dose-limiting toxicities occurred. All patients engrafted with donor cells. Seven patients (54%) developed grade 1-2 acute GVHD (aGVHD), none developed grade 3-4 aGVHD or chronic GVHD, and a low incidence of viral complications was observed. One patient died of nonrelapse mortality; 1 patient relapsed. All others were alive and in remission at last follow-up (median, 14.7 months). NK-cell reconstitution was quantitatively, phenotypically, and functionally superior compared with a similar group of patients not receiving NK cells. In conclusion, this trial demonstrated production feasibility and safety of infusing high doses of ex vivo–expanded NK cells after haploidentical HSCT without adverse effects, increased GVHD, or higher mortality, and was associated with significantly improved NK-cell number and function, lower viral infections, and low relapse rate posttransplant.
Some fixed point results for fuzzy homotopic mappings
Authors: Kiany Fatemeh
Published: August 2017

The first purpose of this paper is to define a homotopy for fuzzy spaces. We continue our work by showing that the property of having a fixed point is invariant by this homotopy. These theorems generalize and improve well-known results.
Efficacy and safety of intragastric balloon in the treatment of obesity in adolescent females
Authors: Pezzo Cynthia Teixeira , de Souza Thiago Ferreira , Fenero Vinícius , Suano-Souza Fabíola Isabel , Grecco Eduardo , Sarni Roseli Oselka Saccardo
Published: August 2017

Background

The aims of this study are to evaluate the efficacy and safety of intragastric balloon (IB) to reduce the weight and body mass index (BMI) in severely obese adolescent females and to describe the changes in the liver enzymes and lipid and glucose metabolism biomarkers.

Methods

This study included 10 severely obese post-menarche adolescent females. We evaluated anthropometric data, lipid profile, glucose metabolism biomarkers, and liver enzymes before insertion and after removal of the IB.

Results

BMI and weight reduction were larger during the first month of intervention. Especially in the first week, there was a reduction of 1.74 ± 0.46 kg/m2 (p = 0.004) and 6.46 ± 1.52 kg (p = 0,002), respectively. After 3 months, there was an average BMI reduction of 4.29 ± 1.04 kg/m (p = 0.005) and weight reduction of 12.9 ± 3.08 kg (p = 0.004). From the initial moment to study conclusion, there was a statistically significant reduction in insulin levels (9.0 ± 2.8 U/mL; p = 0.012) and in homeostatic model assessment-insulin resistance (2.0 ± 0.6; p = 0.009). Five patients reported, during the first week, epigastric pain; nausea and vomiting were observed in two patients. No adolescents presented dysphagia during IB use.

Conclusion

IB use in adolescent females with severe obesity in association with a conservative multidisciplinary treatment had a positive impact in BMI reduction, with few adverse effects. There was also an improvement in insulin resistance.
Fast 3D multichannel deconvolution of electromagnetic induction loop-loop apparent conductivity data sets acquired at low induction numbers
Authors: Guillemoteau Julien , Christensen Niels Bøie , Jacobsen Bo Holm , Tronicke Jens
Published: August 2017

Electromagnetic induction (EMI) sensors using sufficiently low-frequency harmonic sources and sufficiently small loop separations operate in the low-induction-number (LIN) domain for a relatively wide range of background conductivity. These systems are used in diverse near-surface investigations including applications from soil sciences, hydrology, and archaeology. The special case of portable multiconfiguration EMI sensors operating at frequencies [Formula: see text] offers the possibility of using a fast linear deconvolution method to interpret multichannel data sets in three dimensions. Here, we have developed a fast 3D inversion/deconvolution method regularized with 3D smoothness constraints and formulated in the hybrid spectral-spatial domain. Compared with other linear approaches, the spectral-spatial domain formulation significantly reduces the computational cost of the processing and opens the door for real-time 3D interpretation of large data sets consisting of more than 100,000 data points. First, we test our proposed algorithm on synthetic data sets computed with the full Maxwell theory. Then, we apply our method to a real four-configuration EMI data set acquired to map the thickness of peat layers embedded in a sandy environment. For the synthetic and the field example, we compared our result with the result obtained using a standard point-by-point 1D nonlinear inversion approach. This comparison demonstrates that the proposed methodology provides superior lateral resolution compared with the 1D nonlinear inversion, at the same time significantly reducing the computational cost of the processing.
Features of backscatter ionospheric sounding as studied with a chirp ionosonde
Authors: Пономарчук Сергей , Ponomarchuk Sergey , Куркин Владимир , Kurkin Vladimir , Пензин Максим , Penzin Maksim
Published: August 2017

We present the results of studies of backscatter ionospheric sounding (BS) on the basis of a multipurpose chirp ionosonde developed in ISTP SB RAS. We analyze BS experimental data obtained during different seasons from 2005 to 2009. The accumulated dataset allows us to investigate features of BS signal propagation in various heliogeophysical conditions. To analyze and interpret BS signals on ionograms, we use the results of modeling of characteristics for chirp signals in the backscatter and oblique ionospheric sounding under the waveguide approach. We have revealed the most characteristic types of ionograms and have established conditions of appearance of a given type depending on the time of day, season, sounding direction, and medium conditions. In winter, spring, and autumn, the prevailing types of ionograms are those with BS signals corresponding to the propagation mode through reflection from the F layer. Signals reflected by E or Es layers are recorded during summer periods. At the same time, frequencies of the received signals are sufficiently large, and sometimes there are no reflections from the F layer.
Effect of Grape Syrup as a Replacement for Sugar on the Chemical and Sensory Properties of Sponge Cake
Authors: Mehrabi Shima , Koushki Mohammadreza , Azizi Mohammad
Published: August 2017

The present study aimed to investigate the possibility of replacing sugar with different concentrations of natural sweetener (grape syrup) in making low-calorie cakes. For this purpose, different types of cakes with 0%, 50%, 75% and 100% grape syrup were cooked. Then, the chemical and sensory properties of cakes such as moisture content and water activity, PH, protein, sugar and fat content as well as acid-insoluble ash, sensory evolution, and color were studied. Results indicated that an increase in the grape syrup content of samples leads to many changes in their chemical and sensory properties. The sample made of 100% grape syrup showed the maximum content of moisture, water activity and high pH value as well as the minimum level of sugar on the seventh day, and the protein content of the sample remained the same as that of the control sample. The results from the comparison of means for the color parameter in seventh day, indicated that the maximum and minimum level of L* (lightness) belonged to the control treatment and the 100% grape syrup treatment, respectively, in which the cake was darker on the seventh day, while the maximum and minimum level of a*(redness) belonged to the 50% grape syrup and control respectively, the maximum (25% grape syrup) and minimum levels of b* (yellowness) belonged to the treatment and control treatment, respectively. The cake with 100% grape syrup obtained the highest score of sensory evaluation in terms of the quality and color of shell as well as soft texture to the cake, taste and aroma.
A Comparative Study on the Nutritional Profile of Male and Female Sportspersons
Authors: Kaur Harveen , Singla Neerja
Published: August 2017

To study the impact of dietary pattern on nutritional status of sportspersons, a sample of 120 sportspersons including 60 vegetarian and 60 non-vegetarian in the age group of 16-25 years were selected from Punjab Agricultural University and Guru Nanak Stadium, Ludhiana. The data regarding general profile, anthropometric measurements, hemoglobin levels, dietary and nutrient intake of the sportspersons was collected. It was revealed that percent adequacy of all the food groups including cereals, pulses, vegetables and sugar was inadequate. However, intake of fruits and milk and milk products was found to be higher. Among nutrient intake, the percent adequacy of energy, protein, fat and iron was found to be inadequate among vegetarian and non-vegetarian category of both the genders, however, that of calcium, folic acid was found to be more than adequate. Among vegetarian males 6.7 percent and 3.4 percent among non-vegetarian males were found to have a Body Mass Index (BMI) less than 18.5, whereas 40 and 30 percent vegetarian and non-vegetarian females were underweight respectively. The potential health benefits of a vegetarian diet have been reported among non athletes. However, it was considered relevant to consider the benefits of a vegetarian diet among athletes and whether their nutritional status can be improved or compromised in any ways. Therefore, in the present study a comparison was made with regard to various parameters of nutritional status of the vegetarian and non- vegetarian male and female sportspersons.
Pengaruh Kebiasaan Belajar Dan Kreativitas Belajar Siswa Terhadap Hasil Belajar Matematika (Survey Pada SMA Di Kecamatan Ciledug Tangerang)
Authors: Nurdeni Nurdeni , Liberna Hawa
Published: August 2017

The objective of this research is to investigate the influence of students learning activity and creativity toward the math learning achievement. In addition it is to know simultaneously the influence of students learning activity and creativity toward the math learning achievement. The research method is used in this research is survey. There are 60 students come from tenth grader of SMA Numaniyah and SMA Fatahillah Ciledug Tangerang as sample of the research, interview, questionner, and achievement test are used to collect the data. The descriptive statistical is used to analyze the data beside person double correlation coefficient, determination coefficient and regression analysis T and F  test are used to incate the statistical test. The research was conducted on March 2012. The result of the research show that there is simultaneous influence between students learning activity and creativity toward the math learning achievement of tenth grader students at SMA Ciledug Tangerang. It is stated by the quality regression of Y = -6,227 + 0,85 + 0,683. It indicates that one level of improvement of learning activity and creativity will be followed by the students achievement of -6,227. The students learning activity and creativity variables indicates the significance influence toward the students learning achievement. It is shownby the determination coefficient of R2 = 0,777 and F test score = 99,459.
Penyelesaian Masalah Penjadwalan Job-Majemuk dengan Pemakaian Sumberdaya- Majemuk Menggunakan Algoritma Genetika
Authors: Aji Taufiq
Published: August 2017

Scheduling problems with regard to the problem of determining the order to carry out a number of tasks. This issue covers a wide range of areas such as manufacturing, installation project, production planning, hospital management and reservation system. This problem can be seen as an optimization problem of dealing with a number of constraints. An increase in the complexity of the problem requires the existence of an efficient and effective techniques. This study addresses the issue of scheduling multiple job-where there are several different types of resources that are working on an operation or activity simultaneously. Genetic algorithms are developed to solve these problems. Genetic algorithm testing performed against a number of hipotetik example. The output agoritma of genetics compared against optimal technique of the output and the output algorithm based on Lagrange relaxation on the same issue. The results of the comparison with optimal techniques and algorithms based on Lagrange relaxation indicates a significant improvement of computing efficiency, but nevertheless occur a little decrease in effectiveness.
Aplikasi Persamaan Bessel Orde Nol Pada Persamaan Panas Dua Dimensi
Authors: Mulyati Annisa Eki , Sugiyanto Sugiyanto
Published: August 2017

Bessel differential equation is one of the applied equation in physics is about heat transfer. Application of modified Bessel function of order zero on heat transfer process of two-dimensional objects which can be modelled in the form of a two-order partial differential equations as follows, ..... With the obtained solutions of Bessel's differential equation application of circular fin, ....   two-dimensional temperature stated on the point .....  against time t
Aplikasi Algoritma Branch and Bound Untuk Optimasi Jalur Pemadam Kebakaran Kota Yogyakarta
Authors: Margiyani Sri , Mussafi Noor Saif Muhammad
Published: August 2017

Kasus kebakaran di Indonesia, khususnya Kota Yogyakarta dari tahun ke tahun masih menunjukkan angka yang tinggi. Hal ini mengakibatkan kerugian yang cukup tinggi bagi korban kebakaran. Untuk meminimalisasi terjadinya korban jiwa dan kerugian secara material saat terjadi kebakaran, maka pihak pemadam kebakaran mengupayakan melalui rute terpendek untuk sampai di lokasi kebakaran. Tujuan dari penelitian ini adalah pencarian rute terpendek jalur pemadam kebakaran dari kantor pemadam sampai ke lokasi kebakaran. Permasalahan pencarian rute terpendek jalur pemadam kebakaran secara abstrak dapat digambarkan dengan suatu graf yang merupakan masalah optimasi dalam pencarian rute terpendek (Shortest Path Problem). Pemecahan permasalahan tersebut adalah dengan merepresentasikan peta pemadam kebakaran ke dalam bentuk graf berbobot dan berarah, selanjutnya permasalahan diselesaikan menggunakan Algoritma Branch and Bound. Perhitungan dilakukan secara manual dengan jarak (dalam meter) sebagai bobot perhitungan.  Berdasarkan perhitungan menggunakan Algoritma Branch and Bound untuk optimasi jalur pemadam kebakaran Kota Yogyakarta untuk wilayah Kecamatan Umbulharjo menghasilkan solusi rute: Kantor pemadam kebakaran – Jln. Ipda Tut Harsono - Jln. Kusumanegara – Jln. Glagahsari – Kantor Kecamatan Umbulharjo) dengan total jarak 5305 meter atau 5,035 km.
Model Matematika Konflik Tiga Kompartemen (Model Diskret)
Authors: Sugiyanto Sugiyanto , Musthofa Muhammad Wakhid
Published: August 2017

The conflict between groups of people is a serious problem for the people of Indonesia. Mathematical Model of trying to resolve this problem. In this study the number of police officers involved have been in accordance with the amount of power a group of warring parties, so that the police can relieve the community because the amount of power that is balanced. In the case study of conflicts in South Lampung as much as 700 police officers who have been involved is in compliance. The victim died because police were too late in fielded as many as 700 police.
The First Manifestation of a Left Atrial Myxoma as a Consequence of Multiple Left Coronary Artery Embolisms
Authors: Novak Martin , Fila Petr , Hlinomaz Ota , Zampachova Vita
Published: August 2017

A case of multiple embolisms in the left coronary artery as a rare first manifestation of left atrial myxoma is reported. A patient with embolic myocardial infarction and congestive heart failure was treated by percutaneous aspirations and balloon dilatations. Transesophageal echocardiography disclosed a villous myxoma with high embolic potential. Surgical resection of the tumour, suturing of a patent foramen ovale suture and an annuloplasty of the dilated tricuspid annulus was performed the third day after the admission. Recovery of the documented left ventricular systolic function can be explained by resorption of myxomatous material. The patient was discharged ten days after the surgery.
Use of Transcranial Doppler in Intensive Care Unit
Authors: Viski Sandor , Olah Laszlo
Published: August 2017

Use of transcranial Doppler has undergone much development since its introduction in 1982, making the technique suitable for general use in intensive care units. The main application in intensive care units is to assess intracranial pressure, confirm the lack of cerebral circulation in brain death, detect vasospasm in subarachnoid haemorrhage, and monitor the blood flow parameters during thrombolysis and carotid endarterectomy, as well as measuring stenosis of the main intracranial arteries in sickle cell disease in children. This review summarises the use of transcranial Doppler in intensive care units.
Game Analysis in a Dual Channels System with Different Power Structures and Service Provision
Authors: Zhang Guoxing , Fang Shuai , Lai Kin Keung
Published: August 2017

This paper studies a dual-channel supply chain in which a manufacturer sells products to a retailer as well as to customers who are sensitive to both channel price and the retail service. Three game models (Manufacturer Stackelberg, Retailer Stackelberg and Vertical Nash) are built according to members’ different bargaining power in a dual channels system. The authors show that customers can receive lower channel price and higher retail service level when channel members have equal bargaining power, however, when the retailer occupies the market leadership, consumers always receive the least welfare because of the higher channel price and lower retail service. Interestingly, the retailer can take advantage of market leadership to make more profits, while the manufacturer is more willing to give up its power and act as a Stackelberg follower. Furthermore, Manufacturer Stackelberg and Vertical Nash is a strictly dominated strategy for the retailer and the manufacturer respectively.
Uniform Parallel Machine Scheduling Problem with Controllable Delivery Times
Authors: Li Kai , Li Hui , Cheng Bayi , Luo Qing
Published: August 2017

This paper considers the uniform parallel machine scheduling problem with controllable delivery times, which assumes that the delivery times of jobs are linear decreasing functions of the consumed resource. It aims to minimize the maximum completion time under the constraint that the total resource consumption does not exceed a given limit. For this NP-hard problem, we propose a resource allocation algorithm, named RAA, according to the feasible solution of the uniform parallel machine scheduling problem with fixed delivery times. It proves that RAA algorithm can obtain the optimal resource allocation scheme for any given scheduling scheme inO(nlogn)time. Some algorithms based on heuristic algorithm LDT, heuristic algorithm LPDT and simulated annealing are proposed to solve the uniform parallel machine scheduling problem with controllable delivery times. The accuracy and efficiency of the proposed algorithms are tested based on those data with problem sizes varying from 40 to 200 jobs and 2 to 8 machines. The computational results indicate that the SA approach is promising and capable of solving large-scale problems in a reasonable time.