bluuebunny/crossref_metadata_2025 huggingface dataset:
ASSISTÊNCIA ÀS MULHERES MASTECTOMIZADAS: PERCEPÇÕES DE FAMILIARES E O DESPERTAR DA PROMOÇÃO DA SAÚDE
Authors: Souza Jeane Barros de , Walker Fernanda , Schleicher Maira Lidia , Reis Luana , Manorov Maraisa , Martins Emanuelly Luize
Published: March 2020

Objetivo: compreender as percepções dos familiares de mulheres mastectomizadas sobre a assistência em saúde e a necessidade de promover a saúde após a vivência do câncer de mama na família. Método: estudo descritivo, exploratório, de abordagem qualitativa, com a participação de nove familiares de mulheres mastectomizadas entre 2012 e 2018. As entrevistas ocorreram em 2018, por meio de questões semiestruturadas. Os dados foram estruturados conforme análise de conteúdo de Bardin. Resultados: as potencialidades destacadas na assistência foram acolhimento, atenção dos profissionais e organização, enquanto as fragilidades foram lentidão, falta de profissionais diante da demanda e falta de apoio psicológico; e em busca da promoção da saúde destacou-se o fortalecimento do autocuidado após a vivência do câncer. Conclusão: as potencialidades assistenciais enfrentavam principalmente a lentidão do sistema, comprometendo a qualidade do atendimento, mas as ações preventivas surgiam como fonte de estímulo ao autocuidado na promoção da saúde.

Descritores: Neoplasias da Mama. Relações Familiares. Assistência à Saúde. Promoção da Saúde. Objective: to understand the perceptions of family members of mastectomized women about health
An Investigation of How Basic Education Level Explains the Phenomena of Unemployment Differently in Urban and Rural Areas
Authors: Sari Melati Inaya , Andriani Setyowati Fitri
Published: March 2020

This study aims to determine the effect of basic education level on unemployment and poverty rate based on the classification of urban and rural areas. The data were taken from Wonosobo Regency as the poorest district in Central Java, Indonesia, with the percentage of poor population of 20.32%. Using descriptive quantitative and linear regressions with dummy variable, we analyzed the distinguished effect of basic education level towards unemployment and poverty rate between urban and rural areas. The results show that, generally, basic education level affected unemployment and poverty rate. The basic education level affected unemployment rate in both urban and rural areas. However, the basic education level in urban area did not have an effect as significant as that in rural area in affecting poverty rate. Urban people faced more competitive workforce market that made them need more than just the basic education. Therefore, even most of them had finished their primary and secondary school; it did not mean they are not going to be trapped in poverty. Meanwhile, the basic education of rural people affected the poverty rate as the more people did not finish their basic studies; the more people had no eligibility in doing proper jobs to achieve the wealth.
 
Keywords: basic education level, poverty, rural area, unemployment, urban area
Investigating the Determinants of Non-Performing Loan: Loan Monitoring As a Moderating Variable
Authors: Khafid Muhammad , . Fachrurrozie , Anisykurlillah Indah
Published: March 2020

The objectives of the study are: 1) to analyze the effects of Capital Adequacy Ratio (CAR), Credit Risk, Loan to Deposit Ratio (LDR), and Net Interest Margin (NIM) to Non- Performing Loan (NPL); 2) to analyze the role of loan monitoring in moderating the effects of CAR, credit risk, LDR, and NIM on NPL. It was a quantitative study. The subject of the study was the Republic of Indonesia Employee Cooperative (KPRI) which had saving and loan business units. Data were collected by conducting documentation (to collect data on CAR, Credit Risk, LDL, NIM, and NPL) and distributing questionnaires (to collect data on loan monitoring). Then, data were analyzed by moderated regression. The results showed that CAR and NIM did not influence NPL, credit risk and LDR had a positive effect on NPL; Then, loan monitoring moderated the effects of NIM on NPL. However; loan monitoring did not succeed to moderate the effect of CAR, credit risk, and LDR on NPL. Based on the results of the study, the cooperatives engaged in the provision of credit need to consider loan monitoring as a very strategic variable to suppress NPL. Thus; it is suggested for the future research to analyze the effectiveness of loan monitoring system at each loaning institution to suppress NPL.
 
Keywords: Capital Adequacy Ratio, Credit Risk, Loan to Deposit Ratio, Net Income Margin, Non-Performing Loan.
The Effects of Leader-Member Exchange and Fun at Work on Work Engagement and Deviant Workplace Behavior in Indonesian Telecommunication Company
Authors: Luthfi Al Hakim Muammar , W. Soetjipto Budi
Published: March 2020

This study was conducted to see the effect of leader-member exchange and fun at work on work engagement and deviant workplace behavior in Indonesian Telecommunication Company. Respondents are permanent employees of Telkom Indonesia Company located at the headquarters involving 130 respondents. The data were collected using a set of questionnaires and were analyzed using SEM technique with LISREL 8.80 application. The results showed that leader-member exchange has a positive significant effect on fun at work and work engagement and negative significant effect on deviant workplace behavior. In addition, this study also found that fun at work has a positive and significant effect on work engagement but does not have a significant effect on deviant workplace behavior. This study also compared the direct influence of leader-member exchange on work engagement and deviant workplace behavior with the indirect one through fun at work.
Keywords: leader-member exchange, fun at work, work engagement and deviant workplace behavior
Website and Social Media Usage for Internet Reporting (Case Study at Zakah Managament Organization)
Authors: Nurkhin Ahmad , . Kardoyo , . Muhsin , Mukhibad Hasan , . Sumiadji
Published: March 2020

Zakah Management Organization (ZMO) is demanded to improve its transparency and accountability including presenting financial and non-financial information by internet. This study aims to describe and compare the usage of website and social media to report many kinds of information by ZMO at state university in Indonesia. This is descriptive qualitative study. The research object is website and social media of Rumah Amal Salman, Rumah Amal Lazis UNNES and LAZIS UNS. Moreover, the data is collected by observation and documentation method. In addition, the data then analyzed by content analysis. Results show that those ZMO have utilized well both website and social media for internet reporting, especially non-financial information. Website is used to deliver organization profile, product information and other important information that can be useful for donor or muzakki. However, there are two ZMO that have not used website and social media to report their financial state. It is Rumah Amal Lazis UNNES which conducts internet financial reporting but limited to Fund Statement. Furthermore, Facebook and Instagram are considered as social media that mostly used by ZMO. Twitter has not been actively used. In addition, YouTube application has not been maximized. In summary, interaction to muzakki through social media needs to be improved by the ZMO.
Keywords: internet reporting, website, social media, facebook, instagram, twitter, ZMO
Corporate Governance Mechanism, Firm Size and Its Effects on Acceptance of Qualified Audit Opinion
Authors: Suryandari Dhini , Andhika Ega
Published: March 2020

This study aims to examine the effect of internal and external corporate governance mechanisms that are proxied by the size of the independent commissioners, the audit committee’s educational background, the proportion of institutional ownership, audit quality, and company size factors towards acceptance of qualified audit opinion. The population in this study is the infrastructure, utilities and transportation sectors listed in the Indonesia Stock Exchange in 2013-2017. Based on the purposive sampling method, it obtained 120 analytical units from the sample data. The analysis used in this study is logistic regression analysis. The results of this study found that if the size of the company which calculated based on total assets had a negative influence on the acceptance of qualified audit opinion. On the other hand, the element of Good Corporate Governance in the form of independent commissioners, audit committee, institutional ownership, and audit quality has no effect on the acceptance of qualified audit opinion. The conclusion of this study is the presence of the company’s internal support body are not able to influence the company’s accounting for the better.
Keywords: good corporate governance, qualified audit opinion, firm size
User Acceptance Test for Kaaba Buku Saku Application
Authors: Ajriya Shaffa Amalia Azzam A , Dellyana Dina
Published: March 2020

As one of the countries with a big Muslim population in the world, opportunity of growing an Islamic business in Indonesia has swiftly gained. It is proved by the growth of 95% market share in manufacture, service, and technology areas. This will give a chance for entrepreneurs to follow the wave. One of the entrepreneurs that utilized the opportunity is the developer of Kaaba Buku Saku application. They are releasing solutions for Muslims in a form of mobile applications. Since the launching of this application, Kaaba Buku Saku generates only 30% active user from the total downloader. By using Binary Logistic Regression, it is known that Facilitating Conditions was a significant variable that means the customer would prefer to adopt the application when they have a sufficient resources and knowledge to adopt it. From the customer journey map, it is known that the improvements that should be made by the developer are equipped the prayer time feature with automatically locate feature, adjust the highlight content to be more understandable, launch live location feature for Hajj and Umrah users, give a step by step guidance for the first use, give notification to calibrate the phone for Qibla feature, and the last is launch their iOS version application.
Keywords: Muslim-based mobile application, Kaaba buku saku, binary logistic regression, customer journey map
The Effect Double Job of Audit Committee Member in Remuneration Committee on Audit Fees
Authors: Irsyad Fauzan Akbar Ahmad , Firman Ramadhan Adi
Published: March 2020

The purpose of this study is to examine the effect of double job member of audit committee in remuneration committee on audit fees. This study refers to the Kalerkar (2012), by modifying the use of control variables and research samples. The dependent variables of this study is audit fees, the independent variable is double job in membership of audit committee at remuneration committee, this study also uses control variables to determine audit fees, there are audit risk, audit complexity, auditor characteristics, and audit committee characteristics. This study uses secondary data from annual reports and financial reports of all banking sector companies listed on the Indonesia Stock Exchange (IDX) in 2014-2017. The research sample was taken by purposive sampling method. The total sample in this study is 41 companies. The analysis method used in this study is the multiple linear regression analysis. The results of this study indicate that double job in membership of audit committee at the remuneration committee negatively affects the price of audit fees.
Keywords: Audit Fees, Audit Committee, Remuneration Committee, Double job member of audit committee in remuneration committee.
Brand-Generated Content (BGC) and Consumer-Generated Advertising (CGA) on Instagram: The Influence of Perceptions on Purchase Intention
Authors: Salma Irelli Refi , Chaerudin Rendra
Published: March 2020

Generation Y individuals start to use social media as their primary tools to obtain information about product and brand. One of the most active social media in Indonesia is Instagram. Broadcasting Brand-Generated Content can be the most common marketing strategy that local fashion brands will use on Instagram. However, the previous study shows that online consumers more likely rely on information generated by other consumers (Consumer-Generated Advertising) than generated directly by marketers (Brand-Generated Content) to assist their purchase decision because they perceive consumers will provide more factual information than the advertiser. Hence, this study objective is to know how does Indonesia consumer perceive Brand-Generated Content and Consumer-Generated Advertising that has been used by a fashion brand on Instagram and which one is the most significant to influence consumer purchase intention. The sample consisted of 165 Instagram active users from Jakarta and Bandung whom voluntary agreed to participate in the online survey of this research. Finding confirmed that consumer perception of BGC and CGA has a positive influence on purchase intention on Instagram. The consumer needed BGC because it consists of important factors that could influence them to have the intention to buy: expertise, relevance, reduce risk, positive valence, usefulness, and credibility. Furthermore, the consumer also needed CGA to support the information of product because CGA has homophily and originality factor.
Keywords: Consumer Perception, Brand-Generated Content, Consumer-Generated Advertising, Purchase Intention, Fashion Brand, Social Media
Investigating the Effects of Psychological Capital on Turnover Intention
Authors: Rivaldi Erwin , Sadeli Jimmy
Published: March 2020

A high level of employee turnover in the company might cause negativity in this company such as decreasing productivity and might take a toll on financial budget. Companies will strive to minimize the level of voluntary employee turnover where possible. PsyCap was explored in many researches related to turnover intention and was positively proven. This study aims to investigate the effects of Psychological Capital (PsyCap on employee turnover intention through three mediating variables. Quantitative methods were used, and this study extracted 257 samples from State-Owned Enterprises (BUMN) engaged in telecommunications in Indonesia. In order to better represent the company as a whole, stratified sampling was used. SPSS software was used to process the data with Process V 3.0 macro as an addition. The results of this study revealed positive & significant relationship of PsyCap towards mediating variables while significant & negative relationship between mediating variables and turnover intention. In addition, there is evidence of mediating effects of PsyCap towards turnover intention through job satisfaction, work engagement and psychological well-being.
Keywords: Psychological capital, work engagement, job satisfaction, psychological well-being, turnover intention
Analysis of Entrepreneurship Behavior and Business Capital Against Business Success
Authors: Nam Hee Jo , Hendrayaty Heny , Mulyadi Hari
Published: March 2020

This study aims to determine the effect of entrepreneurial behavior and business capital on business success. The research method used is quantitative methods and surveys. The population in this study amounted to 263 people. The technique used to determine the size of the sample under study was proposed by Slovin so that respondents who were sampled in this study were entrepreneurs of Binong Jati knitting centers in Bandung as many as 100 respondents. The data analysis technique used is multiple linear regression. Based on the results of the study, it can be seen that entrepreneurial behavior and business capital simultaneously and partially have a positive effect on business success. Based on the results of the study, the recommendations proposed were that entrepreneurial behavior and business capital must be improved so that business success was achieved.
Keywords: Entrepreneurship Behavior, Business Capital, Business Success
Analysis of Tie Strength and Purchase Decision Involvement towards Word-of-Mouth Influence in Service Business
Authors: Qonitah Ummu , Nuraeni Shimaditya
Published: March 2020

The increase in services must be handled, the high cost of services has the potential to shake off economic growth, according to an economic theory called Baumol’s disease. Therefore, services have to become more efficient and productive. A handling service business that mostly intangible are dissimilar from the product-based business. In service word of mouth (WOM) is important. This research would investigate the interaction and direct effects of tie strength which is an interpersonal force between sender and receiver of WOM and the receiver’s service purchase decision involvement which is an intrapersonal force on WOM influence. A secondary aim is to investigate how a distinctive conceptualization of perceived risk affects service purchase decision involvement. A conceptual model incorporating these constructs and associated hypotheses is developed and tested. This research is quantitative research conducted to explore the objective of the study. The researcher conducts a questionnaire to collect data. The purposeful sampling conducted on this research. PLS-SEM Analysis is used in this research for the data analysis. The result indicates tie strength and involvement positively affected WOM influence. However, the moderation effect whereby, tie strength was found to diminish the effect of involvement on WOM influence. The other finding is perceived risk has a highly significant effect on involvement. Also, the relationship between WOM influence and the purchase decision is positively significant.
Keywords: Service, WOM Influence, Purchase Decision, Perceived Risk, Involvement, Tie Strength
Role Conflict Relationships That Can Increase the Satisfaction of Hospital Nurses
Authors: Ranihusna Desti , Ariani Wulansari Nury , Karuma Asiari Dikha
Published: March 2020

Humans in the development of the times, become assets for the organization. The important role of human resources for organizations is a decisive element in the activities of a company. Nurses are one of the important resources owned by hospital organizations. Nursing services are an integral part of health services in hospitals. To develop nurses to be more advanced and developing in order to achieve company goals, then one that is needed is satisfaction in work. Role conflict can affect satisfaction in the workplace. Stress can mediate these factors on job satisfaction. The formulation of this study is how job satisfaction is influenced by the determinants and stressors of hospital nurses. The purpose of this study was to analyze and assess the determinants of job satisfaction for nurses in hospitals and analyze how stressors had an impact on increasing job satisfaction for nurses in hospitals. The sample of this study was170 respondents. The questionnaire returned as many as 160 respondents. This research method with quantitative design uses path analys. Role conflict has a negative influence on job satisfaction. Role conflict has a positive impact on work stress. Job stress has a negative impact on job satisfaction. Role conflict has a negative impact on job satisfaction mediated by work stress.
Keywords: Role Conflict, Work Stress, Job Satisfaction
Are the Financial Performance and Media Coverage Associated with the Quality of Environmental Disclosures?
Authors: Solikhah Badingatus , . Subowo
Published: March 2020

Increased economic growth is positively associated with environmental pollution. The concept of environmental accounting has driven the company’s ability to minimize environmental problems. The purpose of this study was to examine the effect of profitability and media coverage on the quality of environmental disclosures. The population in this study is a company engaged in mining, energy, chemistry, pharmaceuticals, cosmetics, food and beverages that are listed on the Stock Exchange in 2012-2016. Samples were chosen by a purposive method so that 35 companies were selected so that 135 units of analysis were obtained. The data analysis method used is Structural Equation Modeling (SEM) with a Smart PLS 3.0 analysis tool. The results showed that media coverage had a significant positive effect on the quality of environmental disclosures. While profitability is not associated with the quality of environmental disclosures. The practical implications of this study, the results are expected to contribute to the government and stock exchange authorities in order to take immediate action in making policies related to environmental management for listed companies and their reporting to stakeholders.
Keywords: Profitability; Media Coverage; Environment Disclosure
Learning Model Based on Information Technology in an Accounting Education Courses Based on Technology at Faculty of Economics in Universitas Negeri Semarang
Authors: Yoga Baswara Satsya , Widhiastuti Ratieh , Citra Dewi Lita
Published: March 2020

It cannot be denied, nowadays technology is an inseparable part of learning in the classroom and also in the business world. Because of this there are many employers hoping that accounting and accounting education students get teaching about information technology in the field of accounting when they go to college. To fulfill this, in the College in the major of Accounting and Accounting Education curriculum, there are courses called accounting information systems (AIS), Computer Accounting and Introduction to Computer Accounting. This course, if traced back to its origin as mentioned above, is actually one of the very strategic courses. Why is it called very strategic value, because it is closely related to the development of information technology and the demands of the work world that are increasingly here becoming borderless? The teaching curriculum can be very different between each university depending on who and how the subject is coordinated. So that by using information technology learning instruments in the field of accounting developed by Wilis (2016), this study aims to examine a model of how to teach these courses in accounting education by incorporating the practice of using MS Excel in lecture meetings besides emphasizing the use of MS Visio.
Keywords: information technology, computer-based learning, accounting education based on the information technology
Competence of Economic Teachers in the Industrial Revolution Era 4.0: Case Study at State High Schools in Malang City, Indonesia
Authors: Rachmawati Dian , Handayani Sri , Rokhmani Lisa
Published: March 2020

The competencies needed by teachers in the era of disruption according to the Ministry of Education and Culture of the Republic of Indonesia include teachers, gatekeepers, facilitators, catalysts, and connectors. This research was conducted in 10 Public High Schools in Malang City. The focus of research is to find out how the level of competency of economic teachers in the era of industrial revolution 4.0. This research is a preliminary research, through preliminary studies and field surveys. From the survey results, it is known that the competences of economic teachers are still focused on teaching, gatekeepers, and some facilitators. Then the training model to improve teacher competences in the industrial revolution 4.0 era will be very helpful. In the next study, the development of teacher competency training era in the Republic of Indonesia 4.0 will be carried out with the aim of increasing teacher competence, which in the long run will improve the quality of students.
Keywords: teacher competence, industrial revolution 4.0
Benefit Incidence Analysis of Uninhatitable Houses Rehabilitation Program in Indonesia
Authors: Fakhrun Nisa Amalia , Setyadharma Andryan
Published: March 2020

The Government of Indonesia has launched new social assistance program named the Uninhabitable Houses Rehabilitation Program (in Indonesian: Program Rumah Tidak Layak Huni). Uninhabitable Houses Rehabilitation program is a social assistance program that aims to restore social functioning and improve the quality of poor housing that is initially uninhabitable to be habitable. This study aims to evaluate the achievement of the Uninhabitable Houses Rehabilitation Program in Grobogan Regency, Central Java Province, Indonesia. Grobogan Regency has the highest number of uninhabitable houses compared to another regencies and cities in Central Java Province. The method used in this study is Benefit Incidence Analysis (BIA). This model shows the distribution of public expenditure made by the government into different community groups based on the level of income, so that it is expected to explain the progression of the Uninhabitable Houses Rehabilitation program given by the government to the residents of Grobogan Regency. The results of this study indicate that the Uninhabitable Houses Rehabilitation program in Grobogan Regency is a progressive policy, because the benefits received by the poor are more than 10%, i.e. 12,12%.
O jornal escolar na concepção de Célestin Freinet
Authors: Martins Cintia Gonçalves , Rabelo Giani
Published: March 2020

Este artigo se dedica a realizar um diálogo entre a proposta do educador escolanovista Célestin Freinet sobre a utilização dos Jornais Escolares como práticas pedagógicas e a utilização do Jornal Escolar nas escolas do estado de Santa Catarina em meados de 1940, a partir da análise da legislação estadual que regulamentou as Associações Auxiliares da Escola, em especial o Decreto-lei no 3.735/1946 de Santa Catarina. A legislação catarinense de 1946 buscou se aproximar da perspectiva escolanovista com a criação das Associações Auxiliares da Escola às quais a Associação do Jornal Escolar pertenceu. Assim, analisamos a legislação estadual e a difusão, a partir da década de 1920, dos trabalhos de Freinet em relação à prática do Jornal Escolar. No estudo, observamos a tentativa dos governos e dos dirigentes educacionais do estado catarinense de se aproximarem das ideias pedagógicas escolanovistas com a prática dos Jornais Escolares. Todavia, na realização da análise, observamos contradições entre a proposta da legislação e os princípios de Freinet sobre a utilização do Jornal Escolar.
Platelet Rich Plasma in the Treatment of Superficial Digital Flexor Tendon Core Lesion in Donkeys: Histopathological Assessment
Authors: Mostafa Mohamed , Khalil Ahmed , Adel Al-Akraa , Al-Akraa Adel
Published: March 2020

The aim of this study was to assess the effect of platelet rich plasma (PRP) on the healing of created core lesions in the superficial digital flexor tendon (SDFT) in donkeys. Serial histopathological specimens were taken from normal and at 5th, 15th, 30th, 60th and 90th days post PRP treatment. Histopathological findings showed early rapid healing process with early angiogenesis, increased fibroblastic condensation, the nuclei appeared more elongated, flattened arranged in the peripheral collagen fibers. The collagen fibers changed from randomly arranged to semi-parallel and finally highly reoriented parallel closely packed collagen fibers at 90th days of PRP treatment. Compared to saline control displayed few scattered fibroblasts and angiogenesis. As well as less regularly arranged collagen fibers. Histopathological evaluation 90 days after three successive PRP treatment proved a more rapid tendon tissue reconstruction and maturation similar to the healthy tendons.
Effect of Micronutrients on Growth and Flowering of Marigold cv. Siracole
Authors: Pradhan Sumita , Mitra M.
Published: March 2020

A field experiment was conducted to evaluate the effect of FeS04, MnS04 and their combination on growth and flowering of Tagetes erecta cv. Siracole. Highest linear growth (68.88cm) of marigold was recorded in plants treated with 0.25%MnS04+ 0.25%FeS04. Plant spread (63.79cm), number of branches (19.10), leaf area (5.36cm.sq.), fresh and dry matter accumulation (431.69g and 105.59g), crop growth rate (7.98 g/m.sq./days), biomass duration (2783.03 g.days), number of flowers per plant (78.66), yield of flowers (35.99 t/ha) and petal meal per kilogram of fresh flowers (390.3 g/kg) and carotene content (2.26mg/g) were recorded highest in plants treated with 0.5 % FeS04+ 0.25 %MnS04 at all stages of crop growth. Plant chlorophyll and iron content were recorded highest with 0.5%FeS04 while manganese content was significantly increased with the application of MnS04@0.5%.
Socio-Economic Characteristics and Composition of Sheep and Goat Farming under Extensive System of Rearing
Authors: Shivakumara C. , Reddy B. S. , Patil S. S.
Published: March 2020

Sheep and goat play an important role in Indian economy and source of livelihood and employment to millions of rural households. Sheep and goats in India are mostly maintained on natural vegetation on common grazing lands, wastelands and uncultivated (fallow) lands, stubbles of cultivated crops and top feeds (tree loppings). Rarely they are kept on grain, cultivated fodder or crop residue. Sheep and goat rearing is the backbone of the economy of small and landless farmers in India. The study was carried out in Tumakuru, Chitradurga, Belagavi and Kalaburagi districts of Karnataka. The results of the study revealed that majority of the sheep and goat farmers belonged to age group of above 40 years and are illiterate (50-52%). The family size of sheep and goat rearing households have medium size with 4-6 members. The maximum number of farmers were having income of less than `1 lakh per annum, who belonged to backward class, scheduled caste and scheduled tribe. The total number of sheep per household were 25, 67 and 27 under small, medium and large herd size with an overall average of 71 sheep per farm. Similarly, about 17, 29 and 43 goats were found in small, medium and large flock size of goat with an average of 30 goats per flock. Majority of the farmers were having kaccha type of shed for rearing sheep (41.66%) and goat (80%).
Requisição de Análises de “Rotina” em Medicina Geral e Familiar: Um Estudo Observacional Transversal Analítico Baseado na Prática em Portugal
Authors: Conde Margarida Gil , Ramos Raquel Carmona , Rente Ana , Afonso Carina , Henriques Cristina Jesus , Reis Rita Grossinho
Published: March 2020

Introdução: Em Portugal os utentes têm a convicção de que devem realizar análises laboratoriais mesmo na ausência de fatores de risco, nomeadamente história familiar. Estas são designadas análises de “rotina”. O presente estudo pretendeu analisar o padrão de requisição de análises de “rotina” em Medicina Geral e Familiar em Portugal.Material e Métodos: Desenvolvemos um estudo observacional transversal analítico que teve como população alvo os médicos pertencentes aos cuidados de saúde primários em Portugal. Os médicos foram questionados quanto ao seu padrão de requisição e sobre quais os motivos da requisição ou não de análises de “rotina”. As questões tiveram por base as análises clínicas mais prescritas pelos médicos do Agrupamento de Centros de Saúde Lisboa Central.Resultados: A maioria dos médicos afirmou prescrever análises de “rotina” (51,4%). Verificou-se uma relação estatisticamente significativa entre ser especialista e a requisição de análises de “rotina” (p = 0,013). As análises clínicas mais prescritas na idade adulta foram a determinação de colesterol total (92,2%) e de glicemia. Na idade pediátrica foram a determinação de glicemia, de colesterol total e o hemograma. A maioria dos médicos (79,4%) que prescreve análises de “rotina” fá-lo como forma de rastreio e os não prescritores não realizam análises maioritariamente (80,8%) porque não se encontra de acordo com a evidência científica.Discussão: No nosso estudo observámos diferenças na prática de Medicina Geral e Familiar em Portugal, nomeadamente no que diz respeito à requisição de análises de “rotina” por médicos de diferentes regiões, graus de especialização e idade. Verificámos que existe uma associação entre prescrever análises de rotina e o pedido das mesmas para realização de rastreio o que parece demonstrar que os médicos que referem prescrever análises de “rotina” têm a intenção, com as mesmas, de rastrear diversos tipos de patologia, embora os doentes não apresentem sintomatologia ou riscos que o justifiquem. A maior parte dos médicos que não prescreve análises de “rotina”, não concordam com o rastreio de indivíduos assintomáticos o que está de acordo com a evidência.Conclusão: Os nossos resultados sugerem que existe um pedido excessivo de análises de “rotina” que pode levar a sobrediagnóstico e sobretratamento sendo para isso necessária a criação de estratégias globais de marketing social para mudar a cultura vigente.
Truncations of W∞ Algebras
Authors: Fellah Mohammed Akram
Published: March 2020

We introduce a new class of Vertex Operator Algebras Y+ and their duals, which generalize the standard W-algebras WN of type sl(N). These algebras can be defined in terms of junctions of boundary conditions and interfaces in the GL-twisted N = 4 Super Yang Mills gauge theory. The aim of these technical calculations is to find the relation of these ortho-symplectic Y-algebras to truncations of even W\infinity.
Genome Editing: An Emerging Tool for Plant Breeders
Authors: Kumar Anand , Sandhu Karansher
Published: March 2020

Conventional plant breeding has contributed enormously towards feeding the world and has played crucial roles in the development of modern society. The conventional method creates variation by transferring genes between or within the species. In general, these methods are more expensive and takes more time, to overcome these limitations, new technology is required. Genome editing is a powerful tool for biotechnology applications, with the capacity to alter the function of any gene. With the availability of gene information for the majority of the traits, genome editing emerged as a potential to create a new variation with the introduction of any transgene. The important genome editing tools used nowadays are ZFNs, TALEN, Pentatricopeptide repeats protein, adenine base editor, RNA interference, and CRISPR/Cas9. These tools have opened a new era for crop improvement. Due to the complex genetic architecture of most traits, it is challenging to edit genes controlling them. To overcome these challenges, genome editing provides a broader perspective. Among the above-mentioned tools, CRISPR/Cas9 is the most powerful tool for gene editing. These technologies are being used to create abiotic and biotic resistance crop varieties.
Per-head cost of patients responding to eltrombopag and rituximab in the treatment of primary immune thrombocytopenia in Spain.
Authors: Gonzalez-Porras José Ramón , Parrondo-García Francisco Javier , Anguita Eduardo
Published: March 2020

Background: Splenectomy, thrombopoietin receptor agonists (TPO-RAs) and rituximab are the second-line treatments for steroid-resistant adult primary immune thrombocytopenia (ITP). The last two are becoming the most widely used treatments to avoid splenectomy adverse effects and inconveniences. However, the choice between rituximab and TPO-RAs is unclear. Therefore, the treatment cost may be of particular interest to prioritize the therapy option. Our aim is to determine the cost per patient after 6 months of treatment of rituximab compared to TPO-RA eltrombopag in a European Health Service. Methods: A 26-week decision tree model was developed to assess the cost of treatment response of adult patients with chronic-refractory ITP to eltrombopag and rixutimab from the perspective of the Spanish National Health System. Effectiveness was obtained from the literature, and cost was obtained from the official rates. Costs were expressed in € (2018). Due to the short period of assessment, no discount rate was applied. Results: The average cost per patient after 6 months of treatment was similar for eltrombopag and rituximab, although the first cost was slightly higher. However, the greater response rate of eltrombopag decreases the bleeding costs, resulting in a 29% higher cost with rituximab treatment. Eltrombopag cost was always lower, except in the sensitivity analysis in which the patient received a daily dose of 75 mg of eltrombopag, a scenario where eltrombopag cost is 48€ higher than that of rituximab. Conclusions: The treatment cost of rituximab, including monitoring and bleeding costs, is higher than eltrombopag, favouring the latter over rituximab treatment.
Undesirable Perioperative Anesthesia Outcomes at Two National Referral Hospitals, a cross sectional study in Eritrea
Authors: Andemeskel Yonatan Mehari , Elsholz Traudl , Gebreyohannes Ghidey , Tesfamariam Eyasu H.
Published: March 2020

Background: Perioperative undesirable anesthesia outcomes are common among patients undergoing surgery. They may affect body systems and lead into more serious intraoperative and postoperative problems. This research is conducted in the Eritrean National Referral Hospitals with the aim of assessing the prevalence of undesirable anesthesia outcomes during the perioperative period. Method: A cross sectional study design was applied on 470 patient who underwent different types of surgeries with in a three month period. Patients were interviewed 24 hours after operation using the Leiden preoperative care patient satisfaction questionnaire (LPPSq). This study reports one component of a large study conducted. The dimension “Discomfort and needs” of the LPPSq was considered and the measurement of that dimension are presented in this report. Items of the dimension were standardized and measured using a five point Likert scale from “Not at all” to “Extremely”. Multivariable logistic regression was used to look for the association of the outcomes with the types of surgery and types of anesthesia using SPSS (Version 22). Statistical significance level was set at p< 0.05. Results: The prevalence of undesirable anesthesia outcomes were computed in two manners; prevalence of those with ‘at least a little bit’ outcomes which was computed to see the total occurrence of these outcomes and prevalence of those having ‘more than moderate’ outcomes to see the severe experience of these outcomes. Prevalence of the predominant undesirable outcome, post-operative pain, for ‘at least a little bit’ and ‘more than moderate’ were 82.6% and 43.6% respectively. The rest post-operative undesirable outcomes were less frequently reported. Conclusion: Postoperative pain was found to be the most prevalent undesirable outcome. Enhancement of the proper assessment and management of postoperative pain through the development and implementation of specific pain management modalities is needed. Local guidelines should also be available in these settings for the treatment of acute postoperative pain or other outcomes. Keywords: Leiden preoperative care patient satisfaction questionnaire (LPPSq), Perioperative care, Surgery, Undesirable anesthesia outcomes.
Creation of a Case Definition to Identify People Living with HIV using Canadian Primary Care Sentinel Surveillance Network data
Authors: Boyd Sarah Elizabeth , Chen Tao , Blackmore Jillian , Becker Marissa , Kendall Claire , Singer Alexander , Ireland Laurie , Asghari Shabnam
Published: March 2020

Background: HIV care that has been predominantly specialty based can often be managed in primary care settings. The Canadian Primary Care Sentinel Surveillance Network (CPCSSN) database is a rich source of electronic medical records of primary care practices. A case definition for HIV using CPCSSN allows the examination of epidemiology and healthcare utilization of people living with HIV (PLHIV) whose records are in this database and assists us to better understand the primary care of PLHIV. The objective of this study was to develop a case definition for HIV applicable to the CPCSSN database. Methods: Electronic medical record data from CPCSSN was used to develop a retrospective cohort between 2009 and 2017. We identified all possible records of PLHIV in the CPCSSN dataset based on the presence of HIV codes, keywords and medications. Multiple combination of codes, keywords and medications were analyzed to see which resulted in the most accurate definition of PLHIV. To assess the validity, we linked the data to external references (a Newfoundland and Labrador (NL) PLHIV cohort and Nine Circles HIV clinic in Manitoba) and an internal reference (a random sample of the CPCSSN database which was reviewed by two experts to confirm HIV status). Results: We found that the presence of an HIV keyword along with either an ICD code or taking 3 or more HIV medications concurrently was the most accurate algorithm for predicting PLHIV with a sensitivity of 95%, 97.9% and 88.9%, specificity of 63.5%, 100% and 100% for the NL PLHIV cohort, Nine Circles HIV clinic data and internal reference, respectively. Conclusion: To our knowledge, this is the first study to develop an algorithm for identifying people with HIV applicable to the Canadian Primary Care Sentinel Surveillance Network database. This algorithm-based case definition will support future research investigating the utilization of primary healthcare by PLHIV and facilitate improvements in primary care for PLHIV.
T-cadherin in epithelial ovarian cancer: relationship with cancer progression and drug resistanceT-cadherin in epithelial ovarian cancer: relationship with cancer progression and drug resistance
Authors: Guan Yutao , Lin Yi , Zhang Fubin , Zhou Ling-ling , Chen Yang-ping , Zheng Xiaojiao , Cui Li-ning , Lin Zhong-qiu , Wang Gang
Published: March 2020

Background: T-cadherin plays a crucial role in maintaining normal tissue structure by regulating specific cell adhesion, cellular recognition and signal transduction. The purpose of this study was to evaluate whether T-cadherin influences epithelial ovarian cancer (EOC) progression, differentiation and drug resistance and its possible mechanisms.Methods: Epithelial ovarian carcinoma (EOC, n=63) and relevant contralateral normal ovarian (CNO, n=41) fresh tissues were collected from epithelial ovarian carcinoma patients, and benign ovarian tumour fresh tissues were collected from 55 patients with benign ovarian tumours. The human epithelial ovarian carcinoma cell line A2780 was cultured. T-cadherin expression was assessed by real-time RT-PCR and Western blotting, and the expression of matrix metalloproteinase-2 (MMP-2) was detected by Western blotting. pcDNA‑T‑cad plasmid technology was used to upregulate T-cadherin expression. In addition, A2780 cell migration and invasion ability, viability, colony formation, proliferation, apoptosis and sensitivity to paclitaxel were measured.Results: T‑cadherin mRNA and protein expression in EOC tissues from EOC patients was significantly downregulated, and there was no significant difference between the matched contralateral normal ovarian fresh tissue from the same patient and the benign ovarian tumour tissues from other patients. The migration and invasion abilities, viability, colony formation, and proliferation were attenuated by restoration of T‑cadherin expression in A2780 cells via pcDNA‑T‑cad transfection; apoptosis, MMP-2 expression and sensitivity to Taxol were also enhanced by restored T‑cadherin expression. The T‑cadherin expression level was well correlated with the clinical characteristics and symptoms of EOC patients, including tumour stage, histology, lymph node metastasis, tumour size, distant metastasis and cisplatin resistance.Conclusions: T‑cadherin participates in the processes of epithelial ovarian carcinoma cell migration, invasion, proliferation, apoptosis and sensitivity to paclitaxel and can regulate the expression of MMP-2. Downregulation of T‑cadherin expression may contribute to epithelial ovarian cancer progression, differentiation and drug resistance.
Thermal And Chemical Resistance Of Plasma Sprayed Al2o3, Al2o3-Tio2 Coatings
Authors: Šuopys Airingas , Marcinauskas Liutauras , Kėželis Romualdas , Aikas Mindaugas , Uscila Rolandas
Published: March 2020

In this article, the results of thermal and chemical resistance, of plasma sprayed Al2O3 and Al2O3-13wt.TiO2 coatings on a steel (P265GH) sample are presented. Coatings were formed using air-hydrogen plasma direct current plasma torch at atmospheric pressure. The resistance of coatings was measured by analyzing surface structure, elemental and phase composition of as sprayed coatings and after several heating cycles, imitating application conditions. To make this technology more appealing, by decreasing exploitation cost of standard cast iron grate used in straw pellet broilers, we used cheaper stainless steel with a protective Al2O3 and Al2O3-13wt.% TiO2 coatings. Most of the research done in this field is by using Ar as primary gas, but to decrease the manufacturing cost even further we used Air as primary gas. It was determined that after heat treatment the minor changes in the elemental composition were observed. Meanwhile an additional crystalline phases of metal oxides were detected.
Investigation on COVID-19 Infection Cases in Korea
Authors: Kang Yun Jung
Published: March 2020

On December 31st, 2019, the Chinese government announced officially that the country had a pneumonia case with an unknown cause. After that, Korea had 24 confirmed cases on February 8th, and the number has increased constantly since then. COVID-19, a highly contagious virus, infected another patient, Case No. 31, in Daegu; she was the first patient related to Sincheonji Church in Daegu. Later, the number of cases involved with Sincheonji skyrocketed. On March 6th, 2020, the accumulated number of confirmed cases was 6,284, with 42 dead among them. This study, through collecting epidemiological data about various COVID-19 infection cases, found out that getting together in large groups and religious ceremonies leads to massive infection, and that paying close attention to personal hygiene by wearing masks and sanitary gloves, etc., can prevent the spread of COVID-19. Additional epidemiological data and related studies on COVID-19 infections in Korea might either support or modify this conclusion. However, this study is significant in that it emphasizes the precautionary principle in preventing and managing infectious diseases, and that it has a suggestion for public health policies which are on urgent demand currently.