bluuebunny/crossref_metadata_2025 huggingface dataset:
Introduction: Intensive Family Support Services: Politics, Policy and Practice Across Contexts
Authors: Churchill Harriet , Sen Robin
Published: March 2016

The last twenty years have seen major international developments in welfare state support and services for children, parents and families. Increases in provision occurred within established areas such as welfare benefits, family allowances, child welfare services and maternity leave entitlements; and new ‘forms and modalities of provision’ were introduced (Dalyet al., 2015: 10), in particular parental and paternity leave entitlements; welfare-to-work programmes and active labour market policies; conditional cash support schemes; in-work subsidies for low income families; childcare and early education services; earlier intervention and prevention programmes; parenting and family support services; and inter-departmental, inter-professional and inter-agency models of service provision (OECD, 2009, 2011).
A 60 GHz reconfigurable active phase shifter based on a vector modulator in 65 nm CMOS technology
Authors: Moret Boris , Deltimple Nathalie , Kerhervé Eric , Martineau Baudouin , Belot Didier
Published: March 2016

This paper presents a 60 GHz reconfigurable active phase shifter based on a vector modulator implemented in 65 nm complementary metal–oxide–semiconductor technology. This circuit is based on the recombination of two differential paths in quadrature. The proposed vector modulator allows us to generate a phase shift between 0° and 360°. The voltage gain varies between −13 and −9 dB in function of the phase shift generated with a static consumption between 26 and 63 mW depending on its configuration.
Global Animal Law: What It Is and Why We Need It
Authors: Peters Anne
Published: March 2016

The symposium collection in this issue ofTEL, consisting of four articles including this framing article, seeks to conceptualize and flesh out a new branch of law and legal research: global animal law. The starting hypothesis is that contemporary animal law must be global or transnational (that is, both transboundary and multilevel) in order to be effective. In times of globalization, all aspects of (commodified) human−animal interactions (from food production and distribution, working animals and uses in research, to breeding and keeping of pets) possess a transboundary dimension. Animal welfare has become a global concern, which requires global regulation. This foreword introduces the three symposium articles, sketches out the research programme of global animal law and links its emergence to the ongoing ‘animal turn’ in the social sciences, including political philosophy.
Strategies and Resources to Help Students Evaluate Web-Based Information
Authors: Brown Linda K.
Published: March 2016

When asked to gather information for any type of research project, books are the last place many of our students want to look, unless forced to do so because print sources are required as part of the assignment. The research tool of this “post-literate” generation is the computer, and their most frequently used source of information is the internet. In fact, using the internet seems to be the best way to keep my students engaged in any extensive, or ongoing, research project.
Computergestützte Interventionen bei depressiven Symptomen
Authors: Krause Kristian , Gürtler Diana , Bischof Gallus , Rumpf Hans-Jürgen , Lucht Michael , John Ulrich , Meyer Christian
Published: March 2016

Zusammenfassung. Ziel der vorliegenden Arbeit war es, mithilfe einer systematischen Literaturrecherche die derzeit zugänglichen evidenzbasierten computergestützten Interventionen zur Reduktion depressiver Symptome zu identifizieren. Insgesamt ließen sich 37 Interventionen ausfindig machen, welche überwiegend (51,4 %) ausschließlich auf Methoden der kognitiven Verhaltenstherapie basieren. Für den englischen Sprachraum gibt es ein breites Angebot an internetbasierten, computer- und/oder smartphonegestützten Interventionen. Das deutschsprachige Angebot ist jedoch noch gering. Sprachliche und kulturelle Anpassungen der fremdsprachigen Interventionssysteme für den deutschsprachigen Raum würden eine erhebliche Erweiterung des verfügbaren Angebotes ermöglichen. Zur Ausschöpfung des Potenzials computergestützter Interventionen scheint die Frage essenziell, wie zukünftig Angebote für geeignete Patientengruppen qualitätsgesichert bereitgestellt werden können.
Sexuality-Related Conditions: A Multistakeholder Approach to Explore Feasibility of Field-Testing ICD-11 Revisions in Developing Countries
Authors: Campbell Megan M. , Robles Rebeca , Vieira Denise L. , Khoury Brigitte , Daouk Saria , Stein Dan J.
Published: March 2016

The International Classification of Diseases (ICD) is in the process of being revised. Sexuality-related conditions have been identified as a key area for revision, with the aim of improving clinical utility. Proposed revisions will be field-tested to evaluate their cultural sensitivity, relevance, and appropriateness across developed and developing world contexts. Brazil, Lebanon, Mexico, and South Africa have been identified as potential field-testing sites. The purpose of this article is to describe a multistakeholder consultative approach to explore the feasibility of field studies in these countries. A broad spectrum of ∼30 stakeholders, including health and allied health professionals, legal and human rights advocates, and government sector and civil society representatives, were approached in each of these countries and invited to participate in 3-day workshops to develop potential field-testing protocols. Engagement with these stakeholders revealed challenges for initiating field-testing in these contexts, the most common being the limited access to sexual health treatment facilities for conducting clinic-based research. Potential protocols that accommodated local resources and infrastructure were developed. Secondary outcomes included the broadening of networks for professionals working in the area of human sexuality, mapping of services currently available for sexuality-related conditions locally, increased awareness and discussion about sexuality-related conditions, and the intersection with human and sexual rights.
Screen-printed flexible MRI receive coils
Authors: Corea Joseph R. , Flynn Anita M. , Lechêne Balthazar , Scott Greig , Reed Galen D. , Shin Peter J. , Lustig Michael , Arias Ana C.
Published: March 2016

Magnetic resonance imaging is an inherently signal-to-noise-starved technique that limits the spatial resolution, diagnostic image quality and results in typically long acquisition times that are prone to motion artefacts. This limitation is exacerbated when receive coils have poor fit due to lack of flexibility or need for padding for patient comfort. Here, we report a new approach that uses printing for fabricating receive coils. Our approach enables highly flexible, extremely lightweight conforming devices. We show that these devices exhibit similar to higher signal-to-noise ratio than conventional ones, in clinical scenarios when coils could be displaced more than 18 mm away from the body. In addition, we provide detailed material properties and components performance analysis. Prototype arrays are incorporated within infant blankets for in vivo studies. This work presents the first fully functional, printed coils for 1.5- and 3-T clinical scanners.
Intracellular nanoparticles mass quantification by near-edge absorption soft X-ray nanotomography
Authors: Conesa Jose Javier , Otón Joaquín , Chiappi Michele , Carazo Jose María , Pereiro Eva , Chichón Francisco Javier , Carrascosa José L.
Published: March 2016

We used soft X-ray three-dimensional imaging to quantify the mass of superparamagnetic iron oxide nanoparticles (SPION) within whole cells, by exploiting the iron oxide differential absorption contrast. Near-edge absorption soft X-ray nanotomography (NEASXT) combines whole-cell 3D structure determination at 50 nm resolution, with 3D elemental mapping and high throughput. We detected three-dimensional distribution of SPIONs within cells with 0.3 g/cm3 sensitivity, sufficient for detecting the density corresponding to a single nanoparticle.
DBS-platform for biomonitoring and toxicokinetics of toxicants: proof of concept using LC-MS/MS analysis of fipronil and its metabolites in blood
Authors: Raju Kanumuri Siva Rama , Taneja Isha , Rashid Mamunur , Sonkar Ashish Kumar , Wahajuddin Muhammad , Singh Sheelendra Pratap
Published: March 2016

A simple, sensitive and high throughput LC-MS/MS method was developed and validated for quantification of fipronil, fipronil sulfone and fipronil desulfinyl in rat and human dried blood spots (DBS). DBS samples were prepared by spiking 10 μl blood on DMPK-C cards followed by drying at room temperature. The whole blood spots were then punched from the card and extracted using acetonitrile. The total chromatographic run time of the method was only 2 min. The lower limit of quantification of the method was 0.1 ng/ml for all the analytes. The method was successfully applied to determine fipronil desulfinyl in DBS samples obtained from its toxicokinetic study in rats following intravenous dose (1 mg/kg). In conclusion, the proposed DBS methodology has significant potential in toxicokinetics and biomonitoring studies of environmental toxicants. This microvolume DBS technique will be an ideal tool for biomonitoring studies, particularly in paediatric population. Small volume requirements, minimally invasive blood sampling method, easier storage and shipping procedure make DBS a suitable technique for such studies. Further, DBS technique contributes towards the principles of 3Rs resulting in significant reduction in the number of rodents used and refinement in sample collection for toxicokinetic studies.
Generation of a novel, multi-stage, progressive, and transplantable model of plasma cell neoplasms
Authors: Asai Takashi , Hatlen Megan A. , Lossos Chen , Ndiaye-Lobry Delphine , Deblasio Anthony , Murata Kazunori , Fleisher Martin , Cortizas Elena M. , Verdun Ramiro E. , Petrini John , Nimer Stephen D.
Published: March 2016

Multiple myeloma is a plasma cell neoplasm with an extremely variable clinical course. Animal models are needed to better understand its pathophysiology and for preclinical testing of potential therapeutic agents. Hematopoietic cells expressing the hypermorphic Rad50s allele show hematopoietic failure, which can be mitigated by the lack of a transcription factor, Mef/Elf4. However, we find that 70% of Mef−/−Rad50s/s mice die from multiple myeloma or other plasma cell neoplasms. These mice initially show an abnormal plasma cell proliferation and monoclonal protein production, and then develop anemia and a decreased bone mineral density. Tumor cells can be serially transplanted and according to array CGH and whole exome sequencing, the pathogenesis of plasma cell neoplasms in these mice is not linked to activation of a specific oncogene, or inactivation of a specific tumor suppressor. This model recapitulates the systemic manifestations of human plasma cell neoplasms, and implicates cooperativity between the Rad50s and Mef/Elf4 pathways in initiating myelomagenic mutations that promote plasma cell transformation.
Comparing the defence-related gene expression changes upon root-knot nematode attack in susceptible versus resistant cultivars of rice
Authors: Kumari Chanchal , Dutta Tushar K. , Banakar Prakash , Rao Uma
Published: March 2016

Rice is one of the major staple food crops in the world and an excellent model system for studying monocotyledonous plants. Diseases caused by nematodes in rice are well documented and among them, root-knot nematode (RKN), Meloidogyne graminicola, causes extensive yield decline. It is therefore necessary to identify novel sources of natural resistance to RKN in rice and to investigate the rice-RKN interaction in detail to understand the basal plant defence mechanisms and nematode manipulation of the host physiology. To this end, six different cultivars of rice were initially screened for RKN infection and development; Pusa 1121 and Vandana were found to be most susceptible and resistant to RKN infection, respectively. In order to investigate the role of major hormone-regulated plant defence pathways in compatible/incompatible rice-RKN interaction, some well-identified marker genes involved in salicylate/jasmonate/ethylene pathway were evaluated for their differential expression through qRT-PCR. In general, our study shows a remarkable discrepancy in the expression pattern of those genes between compatible and incompatible rice-RKN interaction. As most information on the molecular interplay between plants and nematodes were generated on dicotyledonous plants, the current study will strengthen our basic understanding of plant-nematode interaction in the monocot crops, which will aid in defining future strategies for best plant health measures.
Illumina microRNA profiles reveal the involvement of miR397a in Citrus adaptation to long-term boron toxicity via modulating secondary cell-wall biosynthesis
Authors: Huang Jing-Hao , Qi Yi-Ping , Wen Shou-Xing , Guo Peng , Chen Xiao-Min , Chen Li-Song
Published: March 2016

The mechanisms underlying tolerance to B-toxicity in plants are still controversial. Our previous studies indicated that B-toxicity is mainly limited to leaves in Citrus and that alternations of cell-wall structure in vascular bundles are involved in tolerance to B-toxicity. Here, miRNAs and their expression patterns were first identified in B-treated Citrus sinensis (tolerant) and C. grandis (intolerant) leaves via high-throughput sequencing. Candidate miRNAs were then verified with molecular and anatomical approaches. The results showed that 51 miRNAs in C. grandis and 20 miRNAs in C. sinensis were differentially expressed after B-toxic treatment. MiR395a and miR397a were the most significantly up-regulated miRNAs in B-toxic C. grandis leaves, but both were down-regulated in B-toxic C. sinensis leaves. Four auxin response factor genes and two laccase (LAC) genes were confirmed through 5′-RACE to be real targets of miR160a and miR397a, respectively. Up-regulation of LAC4 resulted in secondary deposition of cell-wall polysaccharides in vessel elements of C. sinensis, whereas down-regulation of both LAC17 and LAC4, led to poorly developed vessel elements in C. grandis. Our findings demonstrated that miR397a plays a pivotal role in woody Citrus tolerance to B-toxicity by targeting LAC17 and LAC4, both of which are responsible for secondary cell-wall synthesis.
Tunable high-order sideband spectra generation using a photonic molecule optomechanical system
Authors: Cao Cong , Mi Si-Chen , Gao Yong-Pan , He Ling-Yan , Yang Daquan , Wang Tie-Jun , Zhang Ru , Wang Chuan
Published: March 2016

A tunable high-order sideband spectra generation scheme is presented by using a photonic molecule optomechanical system coupled to a waveguide beyond the perturbation regime. The system is coherently driven by a two-tone laser consisting of a continuous-wave control field and a pulsed driving field which propagates through the waveguide. The frequency spectral feature of the output field is analyzed via numerical simulations, and we confirm that under the condition of intense and nanosecond pulse driving, the output spectrum exhibits the properties of high-order sideband frequency spectra. In the experimentally available parameter range, the output spectrum can be efficiently tuned by the system parameters, including the power of the driving pulse and the coupling rate between the cavities. In addition, analysis of the carrier-envelop phase-dependent effect of high-order sideband generation indicates that the system may present dependence upon the phase of the pulse. This may provide a further insight of the properties of cavity optomechanics in the nonlinear and non-perturbative regime, and may have potential applications in optical frequency comb and communication based on the optomechanical platform.
Asymmetrical Deterministic Lateral Displacement Gaps for Dual Functions of Enhanced Separation and Throughput of Red Blood Cells
Authors: Zeming Kerwin Kwek , Salafi Thoriq , Chen Chia-Hung , Zhang Yong
Published: March 2016

Deterministic lateral displacement (DLD) method for particle separation in microfluidic devices has been extensively used for particle separation in recent years due to its high resolution and robust separation. DLD has shown versatility for a wide spectrum of applications for sorting of micro particles such as parasites, blood cells to bacteria and DNA. DLD model is designed for spherical particles and efficient separation of blood cells is challenging due to non-uniform shape and size. Moreover, separation in sub-micron regime requires the gap size of DLD systems to be reduced which exponentially increases the device resistance, resulting in greatly reduced throughput. This paper shows how simple application of asymmetrical DLD gap-size by changing the ratio of lateral-gap (GL) to downstream-gap (GD) enables efficient separation of RBCs without greatly restricting throughput. This method reduces the need for challenging fabrication of DLD pillars and provides new insight to the current DLD model. The separation shows an increase in DLD critical diameter resolution (separate smaller particles) and increase selectivity for non-spherical RBCs. The RBCs separate better as compared to standard DLD model with symmetrical gap sizes. This method can be applied to separate non-spherical bacteria or sub-micron particles to enhance throughput and DLD resolution.
Preliminary analysis of salivary microbiome and their potential roles in oral lichen planus
Authors: Wang Kun , Lu Wenxin , Tu Qichao , Ge Yichen , He Jinzhi , Zhou Yu , Gou Yaping , Van Nostrand Joy D , Qin Yujia , Li Jiyao , Zhou Jizhong , Li Yan , Xiao Liying , Zhou Xuedong
Published: March 2016

Several studies have explored the origin and development mechanism of oral lichen planus (OLP) with limited attention to the role of bacteria in the progression of this common oral disease. Here we utilized MiSeq sequencing of 16S rRNA gene amplicons to identify complex oral microbiota associated with OLP from saliva samples of two subtypes (reticular and erosive) of OLP patients and healthy controls. Our analyses indicated that the overall structure of the salivary microbiome was not significantly affected by disease status. However, we did observe evident variations in abundance for several taxonomic groups in OLP. Porphyromonas and Solobacterium showed significantly higher relative abundances, whereas Haemophilus, Corynebacterium, Cellulosimicrobium and Campylobacter showed lower abundances in OLP patients, as compared with healthy controls. In addition, we explored specific microbial co-occurrence patterns in OLP and revealed significantly fewer linkers of Streptococcus comprising species in erosive OLP. Furthermore, the disease severity and immune dysregulation were also genus-associated, including with Porphyromonas that correlated to disease scores and salivary levels of interleukin (IL)-17 and IL-23. Overall, this study provides a general description of oral microbiome in OLP and it will be useful for further investigation of their potential roles in the initiation and immune modulation of OLP.
Large-scale production of functional human lysozyme from marker-free transgenic cloned cows
Authors: Lu Dan , Liu Shen , Ding Fangrong , Wang Haiping , Li Jing , Li Ling , Dai Yunping , Li Ning
Published: March 2016

Human lysozyme is an important natural non-specific immune protein that is highly expressed in breast milk and participates in the immune response of infants against bacterial and viral infections. Considering the medicinal value and market demand for human lysozyme, an animal model for large-scale production of recombinant human lysozyme (rhLZ) is needed. In this study, we generated transgenic cloned cows with the marker-free vector pBAC-hLF-hLZ, which was shown to efficiently express rhLZ in cow milk. Seven transgenic cloned cows, identified by polymerase chain reaction, Southern blot and western blot analyses, produced rhLZ in milk at concentrations of up to 3149.19 ± 24.80 mg/L. The purified rhLZ had a similar molecular weight and enzymatic activity as wild-type human lysozyme possessed the same C-terminal and N-terminal amino acid sequences. The preliminary results from the milk yield and milk compositions from a naturally lactating transgenic cloned cow 0906 were also tested. These results provide a solid foundation for the large-scale production of rhLZ in the future.
Brain mechanisms associated with internally directed attention and self-generated thought
Authors: Benedek Mathias , Jauk Emanuel , Beaty Roger E. , Fink Andreas , Koschutnig Karl , Neubauer Aljoscha C.
Published: March 2016

Internal cognition like imagination and prospection require sustained internally directed attention and involve self-generated thought. This fMRI study aimed to disentangle the brain mechanisms associated with attention-specific and task-specific processes during internally directed cognition. The direction of attention was manipulated by either keeping a relevant stimulus visible throughout the task, or by masking it, so that the task had to be performed “in the mind’s eye”. The level of self-directed thought was additionally varied between a convergent and a divergent thinking task. Internally directed attention was associated with increased activation in the right anterior inferior parietal lobe (aIPL), bilateral lingual gyrus and the cuneus, as well as with extended deactivations of superior parietal and occipital regions representing parts of the dorsal attention network. The right aIPL further showed increased connectivity with occipital regions suggesting an active top-down mechanism for shielding ongoing internal processes from potentially distracting sensory stimulation in terms of perceptual decoupling. Activation of the default network was not related to internally directed attention per se, but rather to a higher level of self-generated thought. The findings hence shed further light on the roles of inferior and superior parietal cortex for internally directed cognition.
Endoscopic ultrasound-guided fine needle core biopsy for the diagnosis of pancreatic malignant lesions: a systematic review and Meta-Analysis
Authors: Yang Yongtao , Li Lianyong , Qu Changmin , Liang Shuwen , Zeng Bolun , Luo Zhiwen
Published: March 2016

Endoscopic ultrasound-guided fine needle core biopsy (EUS-FNB) has been used as an effective method of diagnosing pancreatic malignant lesions. It has the advantage of providing well preserved tissue for histologic grading and subsequent molecular biological analysis. In order to estimate the diagnostic accuracy of EUS-FNB for pancreatic malignant lesions, studies assessing EUS-FNB to diagnose solid pancreatic masses were selected via Medline. Sixteen articles published between 2005 and 2015, covering 828 patients, met the inclusion criteria. The summary estimates for EUS-FNB differentiating malignant from benign solid pancreatic masses were: sensitivity 0.84 (95% confidence interval (CI), 0.82–0.87); specificity 0.98 (95% CI, 0.93–1.00); positive likelihood ratio 8.0 (95% CI 4.5–14.4); negative likelihood ratio 0.17 (95% CI 0.10–0.26); and DOR 64 (95% CI 30.4–134.8). The area under the sROC curve was 0.96. Subgroup analysis did not identify other factors that could substantially affect the diagnostic accuracy, such as the study design, location of study, number of centers, location of lesion, whether or not a cytopathologist was present and so on. EUS-FNB is a reliable diagnostic tool for solid pancreatic masses and should be especially considered for pathology where histologic morphology is preferred for diagnosis.
Human activity accelerating the rapid desertification of the Mu Us Sandy Lands, North China
Authors: Miao Yunfa , Jin Heling , Cui Jianxin
Published: March 2016

Over the past several thousand years, arid and semiarid China has experienced a series of asynchronous desertification events in its semiarid sandy and desert regions, but the precise identification of the driving forces of such events has remained elusive. In this paper we identify two rapid desertification events (RDEs) at ~4.6 ± 0.2 ka BP and ~3.3 ± 0.2 ka BP from the JJ Profile, located in the eastern Mu Us Sandy Lands. These RDEs appear to have occurred immediately following periods marked by persistently frequent and intense fires. We argue that such fire patterns, directly linked to an uncontrolled human use of vegetation as fuel, played a key role in accelerating RDEs by ensuring that the land surface was degraded beyond the threshold required for rapid desertification. This would suggest that the future use of a massive and sustained ecological program of vegetation rehabilitation should reduce the risk of destructive fire.
Phylogenetic evidence for intratypic recombinant events in a novel human adenovirus C that causes severe acute respiratory infection in children
Authors: Wang Yanqun , Li Yamin , Lu Roujian , Zhao Yanjie , Xie Zhengde , Shen Jun , Tan Wenjie
Published: March 2016

Human adenoviruses (HAdVs) are prevalent in hospitalized children with severe acute respiratory infection (SARI). Here, we report a unique recombinant HAdV strain (CBJ113) isolated from a HAdV-positive child with SARI. The whole-genome sequence was determined using Sanger sequencing and high-throughput sequencing. A phylogenetic analysis of the complete genome indicated that the CBJ113 strain shares a common origin with HAdV-C2, HAdV-C6, HAdV-C1, HAdV-C5, and HAdV-C57 and formed a novel subclade on the same branch as other HAdV-C subtypes. BootScan and single nucleotide polymorphism analyses showed that the CBJ113 genome has an intra-subtype recombinant structure and comprises gene regions mainly originating from two circulating viral strains: HAdV-1 and HAdV-2. The parental penton base, pVI, and DBP genes of the recombinant strain clustered with the HAdV-1 prototype strain, and the E1B, hexon, fiber, and 100 K genes of the recombinant clustered within the HAdV-2 subtype, meanwhile the E4orf1 and DNA polymerase genes of the recombinant shared the greatest similarity with those of HAdV-5 and HAdV-6, respectively. All of these findings provide insight into our understanding of the dynamics of the complexity of the HAdV-C epidemic. More extensive studies should address the pathogenicity and clinical characteristics of the novel recombinant.
Visible light-photocatalysed carbazole synthesis via a formal (4+2) cycloaddition of indole-derived bromides and alkynes
Authors: Yuan Zhi-Guang , Wang Qiang , Zheng Ang , Zhang Kai , Lu Liang-Qiu , Tang Zilong , Xiao Wen-Jing
Published: March 2016

We have developed an unprecedented route to carbazole by a visible light-photocatalysed formal (4+2) cycloaddition of indole-derived bromides and alkynes. Using this method, a wide range of highly functionalised carbazoles were produced in good yields under mild conditions.
Structure modulation, band structure, density of states and luminescent properties of columbite-type ZnNb2O6
Authors: Zhao Dan , Ma Fa-Xue , Zhang Rui-Juan , Li Fei-Fei , Zhang Lei , Yang Juan , Fan Yun-Chang , Xin Xia
Published: March 2016

This study reports the four-dimensional commensurately modulated structure of ZnNb2O6using superspace formalism for aperiodic structures considering the modulation vector,q= 1/3b*.
Achieving sustainable sanitation chains through better informed and more systematic improvements: lessons from multi-city research in Sub-Saharan Africa
Authors: Medland L. S. , Scott R. E. , Cotton A. P.
Published: March 2016

Consolidating findings from research managed by 5 international consortia considering the factors that influence the development and effectiveness of sanitation service chains in 9 cities of Francophone and Anglophone Africa.
A sensitive AIEE probe for amphiphilic compounds
Authors: Palakollu Veerabhadraiah , Vasu Anuji K. , Thiruvenkatam Vijay , Kanvah Sriram
Published: March 2016

AIEE active α-cyanostilbene as a probe for surfactants.
Ageing mechanisms of highly active and stable nickel-coated silicon photoanodes for water splitting
Authors: Han Tingting , Shi Yuanyuan , Song Xiaoxue , Mio Antonio , Valenti Luca , Hui Fei , Privitera Stefania , Lombardo Salvatore , Lanza Mario
Published: March 2016

The performance decay in 2 nm-thick metal-coated silicon photoanodes for water splitting is related to the formation of a thick SiOXfilm at the interface, while thicker coatings live longer and degrade due to the formation of holes.
Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin–MLL interaction
Authors: Zhong Hai-Jing , Lee Bo Ra , Boyle Joshua William , Wang Wanhe , Ma Dik-Lung , Hong Chan Philip Wai , Leung Chung-Hang
Published: March 2016

A natural product-like compound was identified as a direct inhibitor of the menin–MLL interaction after in silico screening and structural modification.
Tuning of dye optical properties by environmental effects: a QM/MM and experimental study
Authors: Del Frate Gianluca , Bellina Fabio , Mancini Giordano , Marianetti Giulia , Minei Pierpaolo , Pucci Andrea , Barone Vincenzo
Published: March 2016

The present work is aimed at a deeper investigation of two recently synthesized heteroaromatic fluorophores by means of a computational multilayer approach, integrating quantum mechanics (QM) and molecular mechanics (MM).
Determination of pseudocontact shifts of low-populated excited states by NMR chemical exchange saturation transfer
Authors: Ma R. S. , Li Q. F. , Wang A. D. , Zhang J. H. , Liu Z. J. , Wu J. H. , Su X. C. , Ruan K.
Published: March 2016

Angular and distance restraints for low populated excited conformations are studied using PCS–CEST NMR spectroscopy.
Selective recognition of c-MYC G-quadruplex DNA using prolinamide derivatives
Authors: Chauhan Ajay , Paladhi Sushovan , Debnath Manish , Dash Jyotirmayee
Published: March 2016

Herein we report the design, synthesis, biophysical and biological evaluation of triazole containing prolinamide derivatives as selectivec-MYCG-quadruplex binding ligands.
Investigation into 9(S)-HPODE-derived allene oxide to cyclopentenone cyclization mechanism via diradical oxyallyl intermediates
Authors: Hebert Sebastien P. , Cha Jin K. , Brash Alan R. , Schlegel H. Bernhard
Published: March 2016

Calculations show that the open shell, diradical pathway is lower in energy than the closed shell reactions forZ- andE-allene oxide to cyclopropanone, and cyclopropanone to cyclopentenone.
The kinetics and mechanism of the organo-iridium-catalysed enantioselective reduction of imines
Authors: Stirling Matthew J. , Sweeney Gemma , MacRory Kerry , Blacker A. John , Page Michael I.
Published: March 2016

The enantiomeric excess (ee) for the organo-iridium catalysed reduction of imines decreases during the reaction because the rate of formation of the (R)-product amine follows first-order kinetics whereas that for the (S)-enantiomer is zero-order.
Facile construction of novel imidazolidine-spirooxindoles via diastereoselective cycloaddition of N-acylhydrazine-derived imines with 3-isothiocyanato oxindoles
Authors: Zhao Hong-Wu , Li Bo , Tian Ting , Song Xiu-Qing , Pang Hai-Liang , Chen Xiao-Qin , Yang Zhao , Meng Wei
Published: March 2016

Diastereoselective cycloaddition of N-acylhydrazine-derived imines with 3-isothiocyanato oxindoles forming novel imidazolidine-spirooxindoles.
A simple synthesis of sulfur-doped graphene using sulfur powder by chemical vapor deposition
Authors: Hassani Fahimeh , Tavakol Hossein , Keshavarzipour Fariba , Javaheri Amin
Published: March 2016

S-doped graphene has synthesized by CVD, using Fe/CaCO3as a catalyst, acetylene as a carbon resource and sulfur powder as a sulfur resource.
Enhanced electrochemical performance of Al–0.9Mg–1Zn–0.1Mn–0.05Bi–0.02In fabricated from commercially pure aluminum for use as the anode of alkaline batteries
Authors: Moghanni-Bavil-Olyaei Hamed , Arjomandi Jalal
Published: March 2016

The electrochemical performance of Al–0.9Mg–1Zn–0.1Mn–0.05Bi–0.02In (wt%) from commercially pure aluminum has been determined using open circuit potential–time measurement, galvanostatic discharge, potentiodynamic polarization and electrochemical impedance spectroscopy.
Effect of ammonium groups on the properties of anion conductive membranes based on partially fluorinated aromatic polymers
Authors: Ahmed Mahmoud Ahmed Mohamed , Mohamed Elsaghier Ahmed Mohamed , Miyatake Kenji
Published: March 2016

Anion exchange membranes based on partially fluorinated segment and oligophenylene with a variety of ammonium cations were synthesized. The copolymer with trimethylammonium groups seemed most promising in terms of the conductivity and the stability.
Preparation of a natural deep eutectic solvent mediated self polymerized highly flexible transparent gel having super capacitive behaviour
Authors: Mukesh Chandrakant , Gupta Rajeev , Srivastava Divesh N. , Nataraj Sanna Kotrappanavar , Prasad Kamalesh
Published: March 2016

2-Hydroxyethyl methacrylate was found to self-polymerize in a natural deep eutectic solvent obtained by the endothermic complexation of choline chloride and orcinol resulting formation of a highly stretchable gel having good capacitive behaviour.
A symmetric organic-based nonaqueous redox flow battery and its state of charge diagnostics by FTIR
Authors: Duan Wentao , Vemuri Rama S. , Milshtein Jarrod D. , Laramie Sydney , Dmello Rylan D. , Huang Jinhua , Zhang Lu , Hu Dehong , Vijayakumar M. , Wang Wei , Liu Jun , Darling Robert M. , Thompson Levi , Smith Kyle , Moore Jeffery S. , Brushett Fikile R. , Wei Xiaoliang
Published: March 2016

A new nonaqueous symmetric redox flow battery was developed based on an organic ambipolar electroactive material. FTIR demonstrated great potential for online monitoring of the state of charge of this flow battery.
Accurate mathematical model of bearingless flywheel motor based on Maxwell tensor method
Authors: Yuan Ye , Sun Yukun , Huang Yonghong
Published: March 2016

It is particularly important to build a correct mathematical model to precisely control single winding bearingless flywheel motor. Thus, a new modelling method based on the Maxwell tensor method is present. Different from the virtual displacement theory, there is no need of the detailed derivation and complex theoretical computation and possesses advantages of universality, accuracy, and directness. Before the mathematical model is established, the fringing magnetic path is improved from straight and circular lines to elliptical line. A correction function is taken to obtain an accurate mathematical model based on finite element analysis (FEA). The FEA results show that the model based on the Maxwell tensor method is feasible and has high precision.
Innovationen kommen ins System
Authors: Mühlnikel Ingrid
Published: March 2016

kma-Interview mit Stefan Etgeton
Revolution im Freistaat
Authors: Mühlnikel Ingrid
Published: March 2016

Die Bayern sind stolz auf ihre Eigenständigkeit. Die beweisen zurzeit gerade auch ein paar tausend Hausärzte im Süden der Republik. Sie wollen kollektiv zum 1. Juli dieses Jahres ihre Kassenzulassung zurückgeben.
Bäng, draufgeklebt
Authors: Zehnder Adalbert
Published: March 2016

Vielen US-Krankenhäusern lief in den 1980er Jahren das Personal in Scharen davon. Aber nicht allen. Denen nicht, die es verstanden, durch attraktive Arbeitsbedingungen Mitarbeiter zu halten und zu beflügeln und dadurch noch bessere Medizin zu machen. Das wiederum übte auf Patienten große Anziehungskraft aus. Die Pflegeakademie AAN prägte für dieses Phänomen das Prädikat “Magnetkrankenhaus”. In Deutschland stößt diese Idee auf wachsendes Interesse.
Goldregen
Authors: Zehnder Adalbert
Published: March 2016

25 Einrichtungen der Kranken-, Behinderten- und Altenpflege sind in Berlin mit dem Gütesiegel “Beste Arbeitgeber im Gesundheitswesen 2008” ausgezeichnet worden. Platz eins belegte dabei das Altenpflegezentrum “Mainterrasse” aus Hanau. Zusätzlich gewann es einen von zwei Sonderpreisen. Damit war der Goldregen für den hessischen Familienbetrieb aber nicht zu Ende: Auch im branchenübergreifenden Hauptwettbewerb landete das Pflegezentrum im Spitzenfeld. Umgeben von Elektronik-, Chemie- oder Softwarekonzernen erzielte die “Mainterrasse” unter den 100 besten deutschen Arbeitgebern Platz 14 – als beste von insgesamt acht Einrichtungen aus dem Gesundheitswesen, die dort vertreten sind.
Auf Augenhöhe
Authors: Gaede Kirsten
Published: March 2016

Peter Bechtel gilt seit Jahren als der kontinuierliche, zuverlässige und vermittelnde Faktor im Vorstand der Bundesarbeitsgemeinschaft Leitender Pflegepersonen (Balk). Nun ist der Pflegedirektor des Herzzentrums Bad Krozingen zum Vorsitzenden des Verbandes gewählt worden.
Nutzen, nicht besitzen
Authors: Zehnder Adalbert
Published: March 2016

In schnelllebigen Zeiten immer das neueste Equipment und das ohne Kapitaleinsatz: Immer mehr Krankenhäuser entdecken das Leasing als Instrument zur Investitionsfinanzierung. Es ist flexibel, bilanzneutral, liquiditätsschonend und verbessert das Rating. Dafür zahlt man aber auch einen Preis.
Onlinepflicht offenbart Bilanzdesaster
Authors: Schmidt Hartmut
Published: March 2016

Die Offenlegungspflichten für Geschäftsberichte haben sich verschärft. Eine Veröffentlichung im Internet ist jetzt Pflicht und bringt die Malaise vieler kommunaler Träger ans Tageslicht. Es wird deutlich, dass der Privatisierungstrend noch lange anhalten wird.
Keine Angst vor Transparenz
Authors: Gaede Kirsten
Published: March 2016

In diesen Tagen startet die Schweiz ein landesweites Pilotprojekt mit den Helios-Indikatoren. Beigetragen zu dieser Entscheidung hat das Universitätshospital Basel, das bereits seit einem Jahr Erfahrungen mit dem System sammelt.
Gesundungsinsel
Authors: Oelschlegel Florian
Published: March 2016

Geht es Kliniken gut, können sie auch für Kassenpatienten Einrichtungen mit Hotel­charakter bauen. Das hat das Herzzentrum Bad Krozingen getan. Und es beweist mit seinem neuen Bettenhaus auch, dass Krankenhausarchitektur mehr sein kann als die fachgerechte Erstellung eines zweckmäßigen Gebäudes: Sie kann Ausdruck einer erfolgreichen Klinikphilosophie sein.
Say it again, Doc!
Authors: Otto Volkmar
Published: March 2016

Ärzte sind gefragte Interviewpartner. Sie nehmen Stellung zu aktuellen Vorfällen an der Klinik, zu allgemeinen Gesundheitsthemen oder zur Berufspolitik. Damitder Auftritt gelingt, empfiehlt sich ein Medientraining. In diesem lernen Mediziner, sich kurz zu fassen, ohne Fremdwörter auszukommen und einem Blackout bei Live­auftritten vorzubeugen.
Eine Messe fürs Krankenhaus
Authors: Thalmayr Maria
Published: March 2016

Verbandsnachrichten der FKT - Fachvereinigung Krankenhaustechnik (e. V.). Diese Seiten sind nur als PDF-Dokument verfügbar.
Strategisch eingekauft
Authors: Zehnder Adalbert
Published: March 2016

Um ihre Position auf dem deutschen Gesundheitsmarkt zu stärken, hat die österreichische Vamed-Gruppe den Krankenhausdienstleister Hermed aus Schleswig-Holstein übernommen. Für den Erwerb des mittelständischen Anbieters durch das international operierende Unternehmen gab das Bundeskartellamt im Februar grünes Licht.
Bitte um Aufschub
Authors: Dirks Claudia
Published: March 2016

Und wieder befinden sich die Krankenkassen in Aufruhr. Das Schreckgespenst “Gesundheitsfonds” zeigt allmählich, neun Monate vor seiner Einführung, seine Wirkung.
Der Lack ist ab
Authors: Mühlnikel Ingrid
Published: March 2016

Noch vor gut zehn Jahren war Privatisierung ein regelrechtes Zauberwort. Modernes Staatswesen bedeutete Privatisierung zentraler, hoheitlicher Bereiche der Daseinsfürsorge. Mittlerweile sind auch private Anbieter durch Marktversagen aufgefallen. Die Krankenhäuser sind von dem Argwohn bislang unberührt geblieben.
Nebliger Ausblick
Authors: Schmidt Hartmut
Published: March 2016

Passable Unternehmensgewinne, hohe Energiepreise – eine eindeutige Aussage über die wirtschaftliche Entwicklung lässt sich derzeit schwerlich treffen. Die große Volatilität der Märkte hält an. Dies gilt auch für die Aktien der stationären Gesundheitsversorger, die sich seit Mitte Februar in einer Kursrange von minus 15 und plus 15 Prozent entwickelt haben.
In gewohnter Manier
Authors: Schmidt Hartmut
Published: March 2016

Rhön befindet sich in ruhigem Fahrwasser: 2007 ist alles wie geplant verlaufen, und auch 2008 muss der Konzern trotz hoher Belastungen keine Abstriche von den Prognosen machen. Die Aktie hat sich marktkonform entwickelt.
Retter des Personalbudgets
Authors: Gaede Kirsten
Published: March 2016

Serviceassistenten liegen im Trend. Krankenhäuser versprechen sich von ihnen Kosteneinsparungen beim Personal. Die Erwartungen werden nicht enttäuscht, wie das Beispiel der Uniklinik Köln und ein Pilotprojekt an der Charité zeigen. Einige organisatorische Vorkehrungen sind jedoch nötig, um Chaos auf Station zu vermeiden.
Der Personalchef liest mit
Authors: Janning Martina
Published: March 2016

Viele Menschen sind im Internet aktiv, suchen Gleichgesinnte, diskutieren oder präsentieren eigene Fotos und Videos. Das stößt auf Interesse – auch bei Personalern. Sie überprüfen Bewerber immer öfter per Onlinerecherche. Der Leumund sollte daher auch im Internet gut sein. Passiert ein Fauxpas, gilt es, ihn zu kaschieren. Dafür gibt es spezielle Firmen.
Die FKT ist dabei
Authors: Thalmayr Maria
Published: March 2016

Verbandsnachrichten der FKT - Fachvereinigung Krankenhaustechnik (e. V.). Diese Seiten sind nur als PDF-Dokument verfügbar.
Ein Servicevertrag für die Haustechnik
Authors: Beutel Jörg , Thalmayr Maria
Published: March 2016

Verbandsnachrichten der FKT - Fachvereinigung Krankenhaustechnik (e. V.). Diese Seiten sind nur als PDF-Dokument verfügbar.
E-Arztbrief für die Reha
Authors: Zehnder Adalbert
Published: March 2016

Die Entlassberichte von Rehapatienten können künftig als elektronischer Arztbrief erzeugt und übermittelt werden. Die Deutsche Rentenversicherung Bund (DRV) und der Verband der Hersteller von IT-Lösungen für das Gesundheitswesen (VHITG) haben einen entsprechenden Implementierungsleitfaden fertiggestellt, den sie auf der Conhit in diesem Monat in Berlin präsentieren wollen.
Unerwartete Wendung
Authors: Mühlnikel Ingrid
Published: March 2016

In der Fachwelt schlug die Nachricht wie eine Granate ein. Der gesamte sechsköpfige wissenschaftliche Beirat zur Entwicklung des morbiditätsorientierten Risikostrukturausgleichs ist zurückgetreten.
Urteil gegen Klinikbewertungen
Authors: Mau Jens
Published: March 2016

In einem Rechtsstreit mit dem Online­portal Klinikbewertungen.de hat eine Klinik zum Teil recht bekommen. Aufgrund eines Urteils des Landgerichtes Landshut gegen Klinikbewertungen.de musste das Onlineportal drei Sätze aus drei Erfahrungsberichten entfernen, die Besucher der Seite verfasst hatten.
Das Land der Roten Laterne
Authors: Zehnder Adalbert
Published: March 2016

Die Krankenhäuser im bevölkerungsreichen Bundesland Nordrhein-Westfalen leiden am stärksten von allen unter dem Mangel an Investitionsmitteln.
Masse ist nicht Klasse
Authors: Schmidt Hartmut
Published: March 2016

Der Gesundheitsmarkt in Deutschland folgt anderen Regeln als in England oder den USA. Dies bekommt auch die US-amerikanische Pflegeheimkette Sunrise zu spüren. Aber nicht nur die sparsamen Deutschen, auch bilanzielle Ungereimtheiten machen dem Premiumanbieter zu schaffen.
Porträt Christian Johner
Authors: Stern Sara
Published: March 2016

Christian Johner ist Experte für Gesundheits-IT und Hochschullehrer. Aber nicht irgendeiner. Er gehört zu jenen in Deutschland seltenen Professoren, die sich wirklich um ihre Studenten kümmern und dafür von denen nur allerbeste Noten erhalten. Damit seine Kurse wirklichkeitsnah bleiben, aber auch zum eigenen Vergnügen, arbeitet Johner neben der Hochschule an der Entwicklung und Qualitätssicherung von Software.
Von Heuschrecken und Strukturkonservativen
Authors: Gerster Florian
Published: March 2016

Politik und Gesellschaft neigen zu pathologischem Lernen: Sind die öffentlichen Haushalte klamm und hoch verschuldet, wird nach Auswegen gesucht.
Keine Hauptverbandsplätze
Authors: Geppert Roland
Published: March 2016

April 2008: Hauptstadtkongress Medizin und Gesundheit 2008 – Vorsicht: Elefantenohren!
Klasse und Masse
Authors: Kolbeck Cornelia
Published: March 2016

Die bevölkerungsreichsten Staaten der Welt, China und Indien, könnten der deutschen Forschungslandschaft bald die Aufträge für klinische Studien abluchsen. Sie haben vor allen Dingen eines: jede Menge Probanden. Das ergab eine Untersuchung des Instituts Arbeit und Technik (IAT) der Fachhochschule Gelsenkirchen.
Ministererlaubnis für Greifswald
Authors: Mau Jens
Published: March 2016

Nach knapp zweijährigem Bangen ist die Fusion der medizinischen Fakultät der Universitätsklinik Greifswald (UKG) mit dem benachbarten Kreiskrankenhaus Wolgast nun in trockenen Tüchern.
Reinhardt geht
Authors: Mau Jens
Published: March 2016

Der Skandal um Schmiergeldzahlungen von Siemens hat die Sparte Healthcare erreicht. Erich Reinhardt ist als Chef der Sparte zurückgetreten und hat auch sein Mandat als Siemensvorstand niedergelegt.
Wahrzeichen aus Glas
Authors: Geisendorf Nicklas
Published: March 2016

Das Klinikum Chemnitz hat etwas geschafft, worüber andere nur nachdenken: Es hat sein Bettenhaus saniert und um einen Zentralbau ergänzt. In der Außenwirkung repräsentativ, schafft er im Inneren dringend benötigten Platz und erschließt mit seinen Komfortzimmern zugleich neue Einnahmequellen. Mit markanter Architektur in exponierter Lage hat sich das Krankenhaus sogar einen Platz in der Stadtsilhouette erobert.
FKT-Shuttle zum Experimental-OP
Authors: Thalmayr Maria
Published: March 2016

Verbandsnachrichten der FKT - Fachvereinigung Krankenhaustechnik (e. V.). Diese Seiten sind nur als PDF-Dokument verfügbar.
Welche Branche trifft sich in Berlin?
Authors: Gerster Florian
Published: March 2016

Für Leser dieser Zeitschrift ist die Antwort klar: Auf dem Hauptstadtkongress trifft sich in diesem Jahr zum elften Mal die deutsche (und internationale) Gesundheitswirtschaft. Eine Erfolgsgeschichte, auf die Initiator Ulf Fink mit Recht stolz ist. Die Teilnahme vieler hochrangiger Repräsentanten des öffentlichen Lebens macht deutlich, in wie vielen Terminkalendern der HSK “geblockt” wird. Für Manager und Akteure der Gesundheitswirtschaft ist er vielfach Pflicht und Kür gleichermaßen geworden.
Den Bock zum Gärtner gemacht
Authors: Schmincke Polly
Published: March 2016

Die EU-Kommission plant eine Aufhebung des Werbeverbots für rezeptpflichtige Arzneien. Ausgerechnet die Hersteller sollen für die objektive Information ihrer Arzneien verantwortlich sein. Die Bundesregierung hat bereits ihr Veto eingelegt.
Bei Null beginnen
Authors: Mühlnikel Ingrid
Published: March 2016

Mit einem pragmatischen Vorschlag meldet sich der Verband der Leitenden Krankenhausärzte (VLK) in die Debatte um die Krankenhausinvestitionsfinanzierung zu Wort. Der Präsident, Hans Fred Weiser, fordert, ab 1. Januar 2009 “bei null anzufangen”.
Wöchentliche Arbeitszeit eines Gesundheits- und Krankenpflegeschülers
Authors: Mühlnikel Ingrid
Published: March 2016

Sachverhalt: Im Streit steht die Dauer der regelmäßigen wöchentlichen Ausbildungszeit eines Gesundheits- und Krankenpflegeschülers und die sich daraus ergebenden Ansprüche auf Mehrarbeitsvergütung.
Baby-Baisse
Authors: Schiekiera Kirsten
Published: March 2016

Seit der Gesundheitsreform 2004 entscheiden sich immer weniger Paare für eine künstliche Befruchtung. Das schürt den Wettbewerb zwischen den Kinderwunschambulanzen der Unikliniken, Privatpraxen und Anbietern im Ausland. Die Unikliniken versuchen, sich durch wissenschaftlich hochentwickelte Verfahren und Rundumangebote zu behaupten.
Akutkliniken im Visier
Authors: Schmidt Hartmut
Published: March 2016

Mit der Erweiterung des Vorstandes um Peter Paul Gardosch plant Marseille den Einstieg ins Krankenhaus­geschäft. Es ist aber nicht sicher, ob dieser Schritt die stark gebeutelten freien Aktionäre besänftigen kann.
Händewaschen reicht nicht
Authors: Wiedemann Doris
Published: March 2016

Defizite oder Schlampigkeiten bei der Bekämpfung von Krankheitserregern schädigen erst den Patienten und dann den Erlös. Es rentiert sich deshalb, in Maßnahmen gegen nosokomiale Infektionen zu investieren.