bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of the formation of liabilities and their management in a credit institution
Authors: Protas N. . , Koshelev M. .
Published: March 2022

The article presents the results of the author's research in the field of formation and management of the bank's liabilities. The concepts of bank liabilities and passive operations were formulated by author. The main principles and factors influencing the management of passive operations of banks were identified, which made it possible to identify the need for regular analysis of the bank's activities in the field of formation and management of liabilities. As part of the analysis of existing approaches and methods for assessing the bank's liabilities, the key requirements that an effective methodology should meet were formulated. The author of the research has formed a general methodology that allows for the most qualitative analysis of the bank's resource base. Based on this methodology, an analysis of the liabilities of Alfa-Bank JSC was carried out, which made it possible to identify problematic issues in this area and form recommendations for their elimination.
Repairing rat calvarial defects by adipose mesenchymal stem cells and novel freeze-dried three-dimensional nanofibrous scaffolds
Authors: Khoramgah Maryam Sadat , Ghanbarian Hossein , Ranjbari Javad , Ebrahimi Nilufar , Tabatabaei Mirakabad Fatemeh Sadat , Ahmady Roozbahany Navid , Abbaszadeh Hojjat Allah , Hosseinzadeh Simzar
Published: March 2022

Introduction: Treatment of critical-sized bone defects is challenging. Tissue engineering as a state-of-the-art method has been concerned with treating these non-self-healing bone defects. Here, we studied the potentials of new three-dimensional nanofibrous scaffolds (3DNS) with and without human adipose mesenchymal stem cells (ADSCs) for reconstructing rat critical-sized calvarial defects (CSCD). Methods: Scaffolds were made from 1- polytetrafluoroethylene (PTFE), and polyvinyl alcohol (PVA) (PTFE/ PVA group), and 2- PTFE, PVA, and graphene oxide (GO) nanoparticle (PTFE/ PVA/GO group) and seeded by ADSCs and incubated in osteogenic media (OM). The expression of key osteogenic proteins including Runt-related transcription factor 2 (Runx2), collagen type Iα (COL Iα), osteocalcin (OCN), and osteonectin (ON) at days 14 and 21 of culture were evaluated by western blot and immunocytochemistry methods. Next, 40 selected rats were assigned to five groups (n=8) to create CSCD which will be filled by scaffolds or cell-containing scaffolds. The groups were denominated as the following order: Control (empty defects), PTFE/PVA (PTFE/PVA scaffolds implant), PTFE/PVA/GO (PTFE/PVA/GO scaffolds implant), PTFE/PVA/Cell group (PTFE/PVA scaffolds containing ADSCs implant), and PTFE/PVA/GO/Cell group (PTFE/PVA/GO scaffolds containing ADSCs implant). Six and 12 weeks after implantation, the animals were sacrificed and bone regeneration was evaluated using computerized tomography (CT), and hematoxylin-eosin (H&E) staining. Results: Based on the in-vitro study, expression of bone-related proteins in ADSCs seeded on PTFE/PVA/GO scaffolds were significantly higher than PTFE/PVA scaffolds and TCPS (P<0.05). Based on the in-vivo study, bone regeneration in CSCD were filled with PTFE/PVA/GO scaffolds containing ADSCs were significantly higher than PTFE/PVA scaffolds containing ADSCs (P<0.05). CSCD filled with cell-seeded scaffolds showed higher bone regeneration in comparison with CSCD filled with scaffolds only (P<0.05). Conclusion: The data provided evidence showing new freeze-dried nanofibrous scaffolds formed from hydrophobic (PTFE) and hydrophilic (PVA) polymers with and without GO provide a suitable environment for ADSCs due to the expression of bone-related proteins. ADSCs and GO in the implanted scaffolds had a distinct effect on the bone regeneration process in this in-vivo study.
Hollow pollen grains as scaffolding building blocks in bone tissue engineering
Authors: Zakhireh Solmaz , Barar Jaleh , Beygi-Khosrowshahi Younes , Barzegari Abolfazl , Omidi Yadollah , Adibkia Khosro
Published: March 2022

Introduction: The current study, for the first time, suggests nature-made pollen grains (PGs) of Pistacia vera L. as a potential candidate for using as scaffolding building blocks with encapsulation capability of bioactive compounds, such as bone morphogenetic protein 4 (BMP4). Methods: A modified method using KOH (5%, 25ºC) was developed to produce nonallergic hollow pollen grains (HPGs), confirmed by energy dispersive X-ray (EDX) analysis, field emission scanning electron microscopy (FESEM), and DNA and protein staining techniques. The in-vitro study was conducted on human adipose-derived mesenchymal stem cells (hAD-MSCs) to investigate the applicability of HPGs as bone scaffolding building blocks. Cytocompability was evaluated by FESEM, MTT assay, and gene expression analysis of apoptotic markers (BAX and BCL2). The osteoconductive potential of HPGs was assessed by alkaline phosphatase (ALP) activity measurement and gene expression analysis of osteogenic markers (RUNX2 and osteocalcin). Results: Findings demonstrated that HPGs can be considered as biocompatible compounds increasing the metabolic activities of the cells. Further, the bioactive nature of HPGs resulted in suitable cellular adhesion properties, required for a potent scaffold. The investigation of apoptotic gene expression indicated a reduced BAX/BCL2 ratio reflecting the protective effect of HPGs on hAD-MSCs. The increased ALP activity and expression of osteogenic genes displayed the osteoconductive property of HPGs. Moreover, the incorporation of BMP4 in HPGs initiated a synergistic effect on osteoblast maturation. Conclusion: Owing to the unique compositional and surface nanotopographical features of the Pistacia vera L. HPG, this microscale architecture provides a favorable microenvironment for the bottom-up remodeling of bone.
Evaluation of poly (lactic-co-glycolic acid) nanoparticles to improve the therapeutic efficacy of paclitaxel in breast cancer
Authors: Cabeza Laura , El-Hammadi Mazen M. , Ortiz Raul , Cayero-Otero Maria D. , Jiménez-López Julia , Perazzoli Gloria , Martin-Banderas Lucia , Baeyens Jose M. , Melguizo Consolación , Prados Jose
Published: March 2022

Introduction: Paclitaxel (PTX) is a cornerstone in the treatment of breast cancer, the most common type of cancer in women. However, this drug has serious limitations, including lack of tissue-specificity, poor water solubility, and the development of drug resistance. The transport of PTX in a polymeric nanoformulation could overcome these limitations. Methods: In this study, PLGA-PTX nanoparticles (NPs) were assayed in breast cancer cell lines, breast cancer stem cells (CSCs) and multicellular tumor spheroids (MTSs) analyzing cell cycle, cell uptake (Nile Red-NR-) and α-tubulin expression. In addition, PLGA-PTX NPs were tested in vivo using C57BL/6 mice, including a biodistribution assay. Results: PTX-PLGA NPs induced a significant decrease in the PTX IC50 of cancer cell lines (1.31 and 3.03-fold reduction in MDA-MB-231 and E0771 cells, respectively) and CSCs. In addition, MTSs treated with PTX-PLGA exhibited a more disorganized surface and significantly higher cell death rates compared to free PTX (27.9% and 16.3% less in MTSs from MCF-7 and E0771, respectively). PTX-PLGA nanoformulation preserved PTX’s mechanism of action and increased its cell internalization. Interestingly, PTX-PLGA NPs not only reduced the tumor volume of treated mice but also increased the antineoplastic drug accumulation in their lungs, liver, and spleen. In addition, mice treated with PTX-loaded NPs showed blood parameters similar to the control mice, in contrast with free PTX. Conclusion: These results suggest that our PTX-PLGA NPs could be a suitable strategy for breast cancer therapy, improving antitumor drug efficiency and reducing systemic toxicity without altering its mechanism of action.
To detect potential pathways and target genes in infantile Pompe patients using computational analysis
Authors: Karadağ Gürel Aynur , Gürel Selçuk
Published: March 2022

Introduction: Pompe disease (PD) is a disease caused by pathogenic variations in the GAA gene known as glycogen storage disease type II, characterized by heart hypertrophy, respiratory failure, and muscle hypotonia, leading to premature death if not treated early. The only treatment option, enzyme replacement therapy (ERT), significantly improves the prognosis for some patients while failing to help others. In this study, the determination of key genes involved in the response to ERT and potential molecular mechanisms were investigated. Methods: Gene Expression Omnibus (GEO) data, accession number GSE38680, containing samples of biceps and quadriceps muscles was used. Expression array data were analyzed using BRB-Array Tools. Biceps group patients did not receive ERT, while quadriceps received treatment with rhGAA at 0, 12, and 52 weeks. Differentially expressed genes (DEGs) were deeply analyzed by DAVID, GO, KEGG and STRING online analyses, respectively. Results: A total of 1727 genes in the biceps group and 1198 genes in the quadriceps group are expressed differently. It was observed that DEGs were enriched in the group that responded poorly to ERT in the 52nd week. Genes frequently changed in the weak response group; the expression of 530 genes increased and 1245 genes decreased compared to 0 and 12 weeks. The GO analysis demonstrated that the DEGs were mainly involved in vascular smooth muscle contraction, lysosomes, autophagy, regulation of actin cytoskeleton, inflammatory response, and the WNT signaling pathway. We also discovered that the WNT signaling pathway is highly correlated with DEGs. Several DEGs, such as WNT11, WNT5A, CTNNB1, M6PR, MYL12A, VCL, TLN, FYN, YES1, and BCL2, may be important in elucidating the mechanisms underlying poor response to ERT. Conclusion: Early diagnosis and treatment of PD are very important for the clinic of the disease. As a result, it suggests that the enriched genes and new pathways emerging as a result of the analysis may help identify the group that responds poorly to treatment and the outcome of the treatment. Obtained genes and pathways in neonatal screening will guide diagnosis and treatment.
Recent advances in cancer immunotherapy: Modulation of tumor microenvironment by Toll-like receptor ligands
Authors: Rostamizadeh Leila , Molavi Ommoleila , Rashid Mohsen , Ramazani Fatemeh , Baradaran Behzad , Lavasanaifar Afsaneh , Lai Raymond
Published: March 2022

Immunotherapy is considered a promising approach for cancer treatment. An important strategy for cancer immunotherapy is the use of cancer vaccines, which have been widely used for cancer treatment. Despite the great potential of cancer vaccines for cancer treatment, their therapeutic effects in clinical settings have been limited. The main reason behind the lack of significant therapeutic outcomes for cancer vaccines is believed to be the immunosuppressive tumor microenvironment (TME). The TME counteracts the therapeutic effects of immunotherapy and provides a favorable environment for tumor growth and progression. Therefore, overcoming the immunosuppressive TME can potentially augment the therapeutic effects of cancer immunotherapy in general and therapeutic cancer vaccines in particular. Among the strategies developed for overcoming immunosuppression in TME, the use of toll-like receptor (TLR) agonists has been suggested as a promising approach to reverse immunosuppression. In this paper, we will review the application of the four most widely studied TLR agonists including agonists of TLR3, 4, 7, and 9 in cancer immunotherapy.
Opioid overdose, interventions, and challenges
Authors: Alaei Samaneh , Omidian Hossein
Published: March 2022

This short letter briefly reviews the significance of opioid overdose as well as the existing approaches to combat the epidemic. It also signifies the importance of naloxone, its commercially available dosage forms, and the unmet need for developing safe and effective naloxone dosage forms that can easily be administered in emergency settings.
Exosomes as versatile nanoscaled biocompartments in cancer therapy and/or resistance
Authors: Rahbar Saadat Yalda , Barar Jaleh
Published: March 2022

Cancer remains to be a major hurdle to global health. Exosomes as a versatile bio-derived platform, hold a bright prospect in nano-scaled delivery/targeting strategies. Shreds of evidence indicate that exosomes have a critical role in drug resistance in cancer cells through various mechanisms including shuttling of miRNAs, drug efflux transporters, and anti-apoptotic signaling. Exosomes’ cargo, particularly miRNAs, may exert both resistance and in a few cases sensitivity to the anticancer agents in targeted cells. Therefore, the source and components of the exosomes should be carefully considered before any application. Our aim in this editorial is to further highlight the role of exosomes in the development of resistance to therapy in cancer cells. As a new chapter for drug delivery, the challenges should be elucidated before exosomes emerge as novel nanoplatforms for cancer therapy.
Influence of choline-based ionic liquids as neoteric green solvents on aqueous solubility of lamotrigine and piroxicam drugs
Authors: Shekaari Hemayat , Basteholia Negar , Mokhtarpour Masumeh , Zafarani-Moattar Mohammed Taghi
Published: March 2022

Background: The low aqueous solubility of three important drugs (betamethasone (BETA), meloxicam (MEL) and piroxicam (PIR)) have been increased by use of deep eutectic solvents (DESs) based choline chloride/urea (ChCl/U), choline chloride/ethylene glycol (ChCl/EG) and choline chloride/glycerol (ChCl/G) as new class of solvents at T = (298.15 to 313.15) K. Methods: DESs were prepared by combination of the ChCl/EG, U and G with the molar ratios: 1:2. The solubility of drugs in the aqueous DESs solutions was measured at different temperatures with shake flask method. Results: The solubility of the investigated drugs increased with increasing the weight fraction of DESs. The solubility data were correlated by e-NRTL and Wilson models. Also, the thermodynamic functions, Gibbs energy, enthalpy, and entropy of dissolution were calculated. Conclusion: At the same composition of co-solvents and temperature, the BETA, PIR and MEL solubility was highest in (ChCl/U + water), (ChCl/U + water) and (ChCl/EG + water) respectively. The calculated solubility based on these models was in good agreement with the experimental values. In addition, the results show that, the main contribution for drugs solubility in the aqueous DES solutions is the enthalpy.
Synergistic effect of quercetin and cobalt ferrite-graphene oxide-based hyperthermia to inhibit expression of heat shock proteins and induce apoptosis in breast cancer cells
Authors: Mobaraki Fatemeh , Nazari Hojjatollah , Lajevardiyan Seyed Ali , Hatamie Shadie , Jafary Hanieh , Hosseinzadeh Simzar
Published: March 2022

Background: Combinatorial medicine includes promising therapeutic methods for diseases such as cancer, whereby various biochemical and physical agents are simultaneously used to remove tumors. For example, the effectiveness of hyperthermia as a new technique for cancer therapy, can be enhanced, if it is combined with chemical compounds. Herein, the influence of quercetin as a heat shock protein (HSP) inhibitor on the efficiency of cobalt ferrite-graphene oxide (CoFe2O4-GO) nanoparticles- based hyperthermia was investigated in an in vitro study. Methods: Firstly, the surface of graphene sheets was decorated with CoFe2O4 nanoparticles (5-8 nm) and assayed using transmission electron microscopy (TEM), vibrating-sample magnetometer (VSM) and X-ray diffraction (XRD) methods. The cytotoxic effect of the corresponding co-implementation was then examined in MCF7 cell line with or without hyperthermia by (3-(4,5-dimethyl thiazolyl-2)-2,5-diphenyltetrazolium bromide) (MTT) test for 24, 48 and 72 hrs. In addition, the expression of Bax, Bcl2 and HSP70 genes and the production of radicals were evaluated by Real-Time PCR and DPPH (2,2-diphenyl-1-picrylhydrazyl) assays respectively. Results: The study showed that the doses associated with the IC50 points for quercetin and the CoFe2O4-GO nanocomposite were 0.02 mg/ml and 0.001 g/ml, respectively. The results showed that the simultaneous treatment of the cancer cells with quercetin, the nanocomposite, and hyperthermia significantly improves the cytotoxicity effect, increases the expression of Bax gene and down-regulates HSP70 and Bcl2 genes. In addition, the greatest attenuation of DPPH free radicals was observed in the corresponding group. Conclusion: The hybrid treatment of quercetin and the nanoparticle in the presence of hyperthermia could be considered as a promising approach for cancer therapy with minor side effects.
Modulating nimodipine crystallinity for enhancing dissolution: development of geriatric-friendly dosage form
Authors: Abdelrahman Howaida , Essa Ebtessam , El Maghraby Gamal , Arafa Mona Farouk
Published: March 2022

Background: Instant disintegration of oral disintegrating tablets (ODTs) provides greater chance for buccal absorption, avoiding presystemic metabolism of nimodipine. In addition, ODT can be easily dispersed in suitable liquid before delivery via nasogastric tube in critical care setting. Objective: The objective was to improve nimodipine dissolution rate with the goal of developing ODTs for elderly patients, especially those experiencing neurological deficits. Methods: Drop assisted co-grinding of nimodipine with glycine (at molar ratios 1:1, 1:2 and 1:3) or tartaric acid (at molar ratios 1:0.5, 1:1, 1:2, 1:3, and 1:4) was performed. Solid state characterization and in vitro dissolution studies were employed. The optimized formulations were employed to prepare ODTs using suitable excipients. Results: The prepared formulations improved drug dissolution compared to unprocessed and wet ground nimodipine. Fourier–transform infrared spectroscopy, differential scanning calorimetry (DSC), powder X-ray diffraction and scanning electron microscopy suggested transformation of the crystalline structure after co-processing. This was due to salt formation in case of tartaric acid and formation of new crystalline species/ size reduction in case of glycine. These changes were associated with dissolution enhancement. Formulations with highest release efficiency (nimodipine and glycine a molar ratio of 1:1 or nimodipine and tartaric acid at molar ratio of 1:3) were successively incorporated in ODTs which showed fast liberation of nimodipine and dissolution efficiency values of 76 + 0.6 % and 73.3 + 1.7 % for the tablets containing glycine or tartaric acid respectively. Conclusion: The study introduced simple co-grinding approach for dissolution enhancement of nimodipine with high scaling up potential. The developed tablets will increase patient compliance with expected improved bioavailability.
Comparing the efficacy of problem-based learning vs. lectures on the academic achievement and educational motivation of nursing students: A 3-year quasi-experimental study
Authors: Arian Mahdieh , Kamali Azadeh , Oghazian Mohammad Bagher
Published: March 2022

Background: The expansion of roles and the professionalization of nursing obligates instructors to use novel teaching methods, especially problem-based learning (PBL), which provides students with clinical problem-solving skills and promotes lifelong learning. Methods: In a quasi-experimental study, the effects of two teaching methods (traditional lectures and PBL) on academic achievement and educational motivation of nursing students were compared. The study participants consisted of four different classes across four academic semesters of students who had taken a "Respiratory System Diseases and Disorders" theoretical course. The Solomon four-group test was used to remove the sensitizing effect of the pre-test and avoid compromising the external validity of the research. Two classes used the PBL method and two classes used the lecture method. An academic achievement test and the Inventory of School Motivation (ISM) were used to compare the pre-and post-test results. Results: The pre-test indicated the same random effect on all the participants (P>0.05). Both control groups were treated as one general control group (n=52) and both experimental groups were treated as one general experimental group (n=56). The difference between the post-test mean scores of academic achievement and educational motivation was not significant between the two PBL groups (P>0.05) nor the two lecture groups (P>0.05). The PBL and lecture groups differed in their mean post-test scores of academic achievement and educational motivation (P < 0.05), wherein the PBL group showed higher scores than the control group. Conclusion: In traditional learning methods, students gain required knowledge for problem-solving before encountering problems. In PBL, however, knowledge is acquired by actually working on problems. The advantages of PBL include gaining basic knowledge for clinical use, developing effective care, developing personal learning skills, and increasing the desire to learn.
A case of complex treatment of deep burns of the buttocks, perineum, genitals, received by an explosion from a firecracker
Authors: Kozka A. A. , Olifirova O. S.
Published: March 2022

A case of a rare localization of skin lesions by a firecracker flame is described. Burns of II – III degree S 18% of p.t. with lesions of the back, buttocks, perineum, genitals were obtained as a result of illegal actions on the patient. The patient's condition at admission is severe, due to the area and degree of the lesion. Conscious, but intoxicated. Wounds in the perineum, genitals, buttocks, thighs, back are represented by dry white dermis with charring, and on the buttocks – in places with eversion of the subcutaneous tissue. In the area of the vagina, edema and lacerations of the mucous membrane of the labia were observed, at the entrance to the anus there was a hematoma; damage to the rectum and internal genital organs was not revealed. Installed a urinary catheter, the urine is light. In blood tests: leukocytosis, hypoproteinemia, hyperbilirubinemia. Complex treatment included anti-shock, anticoagulant (heparin), antibacterial, analgesic, transfusion therapy (FFP 4750 ml, albumin 10% 800  ml, erythrocyte mass 633 ml), nutritional support (Isosurs). The treatment used a fluidizing bed "Reditron" in the pulse-mode. Bandaging with antiseptics and ointments was regularly performed, staged necrectomies were performed. After preparation of granulating wounds, three stages of autodermoplasty of the above areas were performed on the 30th, 37th, 51st days after the injury. The postoperative period was uneventful. Conservative therapy, physiotherapy, exercise therapy continued. Blood counts returned to normal. Against the background of complex treatment, the patient's skin was completely restored, the functions of the genitals and the anal canal remained.
Modern Clinical Approach in Treatment of Destructive Forms of Chronic Apical Periodontitis
Authors: Байтус Н.А. , Чернявский Ю.П.
Published: March 2022

Целью исследования было клиническое изучение эффективности использования материала «Биопласт-Дент» пасты при деструктивных процессах в тканях апикального периодонта. Объектами исследования явились 22 пациента с деструктивными процессами в тканях периодонта, которые обратились в Клинику ВГМУ и на кафедру терапевтической стоматологии с курсом ФПК и ПК УО «ВГМУ» в период 2014–2018 гг. Временную обтурацию корневых каналов проводили материалом «Биопласт-Дент» паста. Постоянную обтурацию корневых каналов при сохраненной верхушке корня зуба осуществляли с использованием материала на основе эпоксидной смолы и гуттаперчевых штифтов методом латеральной конденсации. При наличии резорбции корня применяли материал на основе минерального триоксидного агрегата – «Рутсил». Окончательную реставрацию коронки зуба осуществляли после рентген-контроля с момента постоянной обтурации корневых каналов через 3 месяца. Всего динамически R-контроль проводили через 3, 6, 12, 24 месяца. Результаты исследования показали эффективность клинического применения гидроксиапатита в 81,82% случаев (p<0,05).

The aim of the study was a clinical study of the effectiveness of the use of "Bioplast-Dent" paste material destructive processes in the tissues of the apical periodontium. The subjects of the study were 22 patients with destructive processes in the periodontal tissues, who applied to the Clinic of the Vitebsk State Medical University and the Department of Therapeutic Dentistry with a course of Faculty of Advanced Training and Retraining Vitebsk State Medical University in the period 2014–2018. Temporary root canal obstruction was performed with "Bioplast-Dent" paste material. Permanent obstruction of the root canals with the preserved apex of the root of the tooth was carried out using a material based on epoxy resin and gutta-percha pins by lateral condensation. In the presence of root resorption, a material based on MTA, "Rооtsil" material was used. The final restoration of the tooth crown was carried out after x-ray control from the moment of constant obstruction of the root canals after 3 months. In total, R-control indicated dynamically after 3, 6, 12,24 months. The results of the study showed the effectiveness of the clinical use of hydroxyapatite in 81.82% of cases (p<0.05).
Kawasaki Disease in Children and Pediatric Multisystem Inflammatory Syndrome Associated with SARS-CoV-2 During the Pandemic (Clinical Lecture)
Authors: Бекетова Г.В. , Солдатова О.В.
Published: March 2022

В статье представлены современные данные о болезни Кавасаки, которая представляет собой генетически обусловленный системный васкулит с поражением коронарных артерий и мультисистемными проявлениями. Этиология до конца не выяснена, однако рассматривается роль вирусов в инициировании аггравированного иммунного ответа с возможным развитием синдромов активации макрофагов и шока, которые могут привести к летальному исходу. Существуют трудности диагностики болезни Кавасаки в связи с разнообразными симптомами, характерными для ряда инфекционных и аутоиммунных заболеваний (скарлатина, корь, иерсиниоз, системный ювенильный идиопатический артрит). Ранняя диагностика и лечение (в первые 10 дней заболевания) с использованием высоких доз внутривенного иммуноглобулина и аспирина ассоциированы с низким риском развития аневризм коронарных артерий и других опасных для жизни осложнений. Также авторами представлены данные об особенностях Кавасаки-подобных заболеваний с тяжелым течением, которые регистрировались в ряде стран Европы и Америки на пике пандемии COVID-19 и диагностические критерии педиатрического воспалительного мультисистемного синдрома, связанного с SARS-CoV-2, предложенные Королевским колледжем педиатрии и детского здоровья (Великобритания).

The article presents modern data about Kawasaki disease, which is a genetically determined systemic vasculitis with damage to the coronary arteries and multisystem manifestations. The etiology is not fully understood, but there is considered a possible role of viruses in the initiation of the aggravated immune response with possible development of macrophage activation syndromes and shock, which can lead to death. There are difficulties in diagnosing Kawasaki diseasedue to a variety of symptoms that are typical for a lot of infectious and autoimmune diseases (scarlet fever, measles, yersiniosis, systemic juvenile idiopathic arthritis). Early diagnosis and treatment (in the first 10 days of illness) using high doses of intravenous immunoglobulin and aspirin are associated with a low risk of development of coronary aneurysms and other complications. The authors also presented the data on the characteristics of severe Kawasaki-like diseases, which were recorded in several countries of Europe and America at the peak of the COVID-19 pandemic, and diagnostic criteria for the pediatric multisystem inflammatory syndrome associated with SARS- CoV-2, proposed by the Royal College of Pediatrics and Children Health (UK).
Continuación y addenda a listas bibliográficas sobre publicaciones de Hymenoptera (Insecta) en revistas científicas chilenas 2005-2021 (II)
Authors: Chiappa Elizabeth , Llerena Pablo
Published: March 2022

Se presenta una lista de las publicaciones sobre Hymenoptera (2005 a diciembre 2021), publicadas en revistas científicas chilenas, que corresponde a una continuación y aditamento a trabajos previos sobre esta materia, agregando 16 años a esas listas. Durante este período se publicaron 203 artículos sobre Hymenoptera y la revista más solicitada para publicar fue la Revista Chilena de Entomología.
Emerging Technologies: Factors Influencing Knowledge Sharing
Authors: Tiwari Siddhartha Paul
Published: March 2022

As advances in emerging technologies continue to transform the business landscape, knowledge sharing will become increasingly important to leveraging the unique core competencies of organizations so as to gain a competitive advantage. Despite emerging technologies being so popular in news and media publications, knowledge sharing remains an area of research that is under-researched in the emerging technologies context. This research aims to identify the barriers and factors to knowledge sharing within an emerging technology context. A comprehensive in-depth interview was conducted with 38 professionals working in 5 organizations engaged in the field of emerging technologies in order to arrive at the findings discussed in this paper. Based on the analysis of the surveys, we found that there are six main factors driving the need for sharing knowledge. The six factors are: regular cadence, integrating expertise from different teams, diversity-inclusive social environment, Interconnected platforms that are accessible to all, a regular update schedule that needs to be followed, to create points of contact within different departments of an organization in order to facilitate sharing. It is important to note that the distribution and use of knowledge in organizations is dependent on the interactions between individuals.
Öğrenci Merkezli Yöntem, Teknik ve Stratejilerin Öğrenci Tutumuna Etkisi: Bir Meta Analiz Çalışması
Authors: YAĞAN Saadet Aylin
Published: March 2022

Bu araştırmanın amacı, öğrenci merkezli yöntem, teknik ve stratejilerin öğrencilerin derse karşı tutumları üzerindeki etkisini incelemektir. Araştırmada meta-analiz yönteminden yararlanılmıştır. Veriler Yükseköğretim Kurulu (YÖK) Ulusal Tez Merkezi’nden erişilebilen lisansüstü tezlerden edinilmiştir. Meta analize dâhil edilme kriterlerini karşılayan 35 teze ulaşılmış bu tezlerden 39 etki büyüklüğü hesaplanmıştır. Verilerin analizinde her bir çalışmaya ait bireysel etki büyüklükleri ve genel etki büyüklüğü hesaplanmıştır. Ayrıca öğrenim düzeyi ve öğrenme alanı değişkenlerinin etkisi de incelenmiştir. Araştırmada öğrenci merkezli yöntem, teknik ve stratejilerin öğrenci tutumunu olumlu yönde geliştirmede orta düzeyde etkili olduğu sonucuna varılmıştır. Öğrenim düzeyi ve öğrenme alanlarına göre etki büyüklükleri farklılaşmaktadır. Bu sonuçlara dayalı olarak öğrenci merkezli yöntem, teknik ve stratejilerin öğretim aşamasında kullanılması ancak öğrenim düzeyi ve öğrenme alanı özelliklerinin göz önünde bulundurulması önerilmiştir.
WILSON’S DISEASE A RARE AND FATAL DISEASE: CASE REPORT AND REVIEW OF LITERATURE
Authors: Jain Prasad , Rajur Rashmi , Shrestha Suraj , Lakhyani Drishti
Published: March 2022

Wilson’s disease is a rare inherited autosomal recessive disorder of copper metabolism leading to various clinical, biochemical and radiological
features. In this disorder there is accumulation of copper in various tissues like liver, brain, cornea, etc., due to impairment in excretion of copper
from body. In today’s world Wilson’s disease has been evolved from fatal disease to a treatable condition were life expectancy and quality of life has
been increased to a great extent. With advancement in diagnostic modalities there has been a drastic change in understanding the disease pathology
and to nd treatment for better outcome for the patients. Earlier when there were delay in diagnosis and treatment of these patients, it led to early
fatalities but is uncommon now. We present you a case of a 20 year male patient who was diagnosed with Wilson disease after he developed liver
cirrhosis which proved fatal for him.
EVALUATION OF FUNCTIONAL OUTCOME BASED ON ACETABULAR COMPONENT PLACEMENT IN TOTAL HIP REPLACEMENT
Authors: Ampolu Atchuta Rao , Kanugula Sai Bharath , Kumar Patnala Ashok
Published: March 2022

BACKGROUND; Total hip arthroplasty (THA) is one of contemporary medicine's true successes (1,2). People with crippling hip diseases could only look forward to living out their years in excruciating pain for generations. For most patients who were unfortunate enough to be aficted, the unrelenting advancement of hip illness resulted in a downward spiral of limited function. Although early attempts at inter-positional arthroplasty and resurfacing operations frequently failed, the development of contemporary THA has provided surgeons and patients with a safe and effective treatment for hip arthritis. Based on a pelvic radiograph and a CT scan, the purpose of this study is to evaluate the acetabular component version and inclination, as well as the functional outcome of total hip replacement.. METHODS: Study design: Hospital Based Retrospective study. Study period: September 2019 to August 2021. Sample size: 30 RESULTS There were 16 males and 14 females among the 30 patients. In 18 cases, the right side was damaged, while in 12 patients, the left side was affected. Avascular necrosis is the most common reason for total hip replacement in 14 patients, followed by rheumatoid arthritis in three, nonunion neck of femur in three, ignored fracture of neck of femur in two, secondary osteoarthritis in six, and ankylosing spondylitis in two. In our research, the average acetabular cup variant performed well. In axial CT, we employed a modied Murray's technique to measure acetabular version. This was the most widely used strategy in numerous investigations. This approach has a very high accuracy rating of around 95%. In all of the cases, the acetabular cup was anteverted. 90 percent of patients in our study had an excellent functional outcome, 6.3 percent had a good functional outcome, and 3.7 percent had a fair functional outcome. 86.66 percent of acetabular cup placements in our investigation were within acceptable limits. Excessive anteversion was found in just 13.33 percent of acetabular cups. CONCLUSION In our study, 90% of the cases had an excellent Harris hip score, whereas 10% had a good or fair Harris hip score. Excessive anteversion was not linked to joint dislocation, however it did result in limited internal rotation
“EFFECTIVENESS OF CHAIR YOGA IN GERIATRIC WITH TYPE - 2 DIABETES MELLITUS –AN EXPERIMENTAL STUDY”
Authors: patel Charmi , solanki Vidhya
Published: March 2022

Diabetes is a major cause of morbility and mortality through these outcomes are not due to immediate effects of the disorder they are instead related
to the disease that develop as a result of chronic diabetes mellitus Type 2 diabetes accounts for more than 90% of patients with diabetes and leads to
microvascular and macrovascular complications. Objective: The study aims to nd the effectiveness of chair yoga for geriatrics with type -2
diabetes mellitus Method: In a 6-week intervention study 30 participants of diabetes mellitus type 2 were studied. They were divided into a group
by convenience sampling, that participants receive chair yoga. pre and post-treatment data were collected and analyzed using SPSS 22.0 paired ttest were used to nd out the signicance of the treatment. A signica Results: nt improvement in strength (p<0.05) after the treatment was found.
Greater statistically signicant improvement was seen in participants with type-2 DM. The study concluded that the effectiveness of Conclusion:
chair yoga improves muscle strength in participants with type-2 DM and prevents the risk of diabetes mellitus.
Semi-Universal Adversarial Perturbations
Authors: Frecon Jordan , Gasso Gilles , canu stephane
Published: March 2022

The present work introduces a framework for learning and selecting semi-universal adversarial perturbations. It relies on a joint estimation of multiple universal adversarial perturbations which are chosen in an unsupervised manner depending on the sample to attack. Two algorithmic solutions, with convergence guarantees under Lipschitz continuity assumptions, are proposed to handle either small scale or large scale datasets. Numerical experiments, conducted on benchmark datasets, support its unifying aspect between universal and specific attacks as the number of perturbations grows. In addition, the learned perturbations display strong patterns indicative of the existing similarities between the training instances of different classes.
3D Adapted Random Forest Vision (3DARFV) for Untangling Heterogeneous-Fabric Exceeding Deep Learning Semantic Segmentation Efficiency at the Utmost Accuracy
Authors: Alfarisi Omar , Aung Zeyar , Huang Qingfeng , Alhashmi Hamed , Abdelsalam Mohamed , Alzaabi Salem , Al-Khateeb Ashraf , Alyazeedi Haifa , Tzes Anthony
Published: March 2022

Planetary exploration depends heavily on 3D image data to characterize the static and dynamic properties of the rock and environment. Analyzing 3D images requires many computations, causing efficiency to suffer lengthy processing time alongside large energy consumption. High-Performance Computing (HPC) provides apparent efficiency at the expense of energy consumption. However, for remote explorations, the conveyed surveillance and the robotized sensing need faster data analysis with ultimate accuracy to make real-time decisions. In such environments, access to HPC and energy is limited. Therefore, we realize that reducing the number of computations to optimal and maintaining the desired accuracy leads to higher efficiency. This paper demonstrates the semantic segmentation capability of a probabilistic decision tree algorithm, 3D Adapted Random Forest Vision (3DARFV), exceeding deep learning algorithm efficiency at the utmost accuracy.
Vulnerability of Coastal Communities to Sea Level Rise in Brass Local Government Area, Nigeria
Authors: Efere Z.S. , Ohwo O.
Published: March 2022

Coastal communities are continuously under threat of survival due to sea level rise, which has increased their vulnerability to inundation resulting to loss of livelihood, property and land area. Hence, this study investigated the vulnerability of the communities in the Brass coast to the impacts of sea level rise. Three communities (Twon-Brass, Okpoama and Diema) located within 0 – 1.2km from the shoreline, and where economic activities are prominent were purposively selected for the study. To assess the level of vulnerability of these communities to sea level rise, the coastal vulnerability index method comprising of six variables (topography, geomorphology, relative sea level rise rate, annual shoreline erosion rate, proximity to coast and population growth rate) were adopted. Landsat imageries at 10years interval for the period 1999 to 2019 were acquired to analyze the Brass shoreline dynamics. The results revealed that for a period of 20 years (1999-2019), the Brass coast has experienced a net land loss of 364.0km2 and a projected land loss of 910km2 by 2050, based on the current scenario. The study further revealed that Twon-Brass and Okpoama communities have high risk of inundation due to sea level rise with a calculated coastal vulnerability index values of 23.1 and 25.3, respectively; while Diema community had moderate risk of being inundated with a coastal vulnerability index value of 21.9. The study recommends the development of an integrated mitigation and adaptation strategy that would increase the resilience of the coastal communities to withstand the threat of sea level rise.
Determination of Critical Weed Competition Period in Chamomile (Matricaria chamomilla L.) Production at Wondo Genet, Southern Ethiopia
Authors: Negaso Ano Wariyo , Abayechaw Desta , Bayisa Negasu Guteta
Published: March 2022

The study was carried out at Wondo Genet to determine the critical weed competition period for growth, yield, and yield components of the chamomile plant. The weed competition duration had a significant influence on plant height, the number of primary branches/plants, fresh stem yield/plant, fresh leaves yield/plant, fresh and dry flower/plant, fresh and dry flower yield/ha, essential oil content (v/w) and yield kg/ha. The highest fresh and dried flower yield (3780.10 kg/ha) and (798.32 kg/ha) was recorded from weed-free check followed by weed-free for 60 DACE (Days After Crop Emergence) (3652.10 kg/ha) and (789.43 kg/ha), respectively. The maximum essential oil content and yield were recorded from the weed-free check (0.79v/w) and (6.25 kg/ha) whereas the minimum was in the weedy-check (0.10 v/w) and (0.15kg/ha), respectively. The yield losses of chamomile were estimated based on the fresh and dry flower and essential oil yield per hectare. Thus, the highest fresh and dry flower yield losses were recorded from the weedy-check (83.58%) and (81.05%) while the lowest was from weed-free check (0.00%), respectively. The highest essential oil yield loss was also recorded from the weedy for 60DACE (97.92%) followed by weedy-check (97.60%). To determine the beginning and the end of the critical period of crop-weed competition 5 and 0% acceptable yield loss levels were used. Therefore, to reduce the yield losses of chamomile by more than 10% and higher economic return, plants must be kept weed-free within 40 to 60DACE to reduce the risk of economic yield losses as it is the critical period of weed-crop competition in chamomile plants.
Strengthening the Management of Projects Using Investment Capital from the State Budget: Necessity and Recommendations for Solutions
Authors: Huong Pham Nguyen Quynh
Published: March 2022

In the past time, the management of investment projects using state budget capital has had many positive changes, the quality of project appraisal, design appraisal is implemented after basic design (technical design). techniques) of specialized agencies has improved day by day, many works and projects after being completed and handed over and put into use are of high quality and effective. However, besides that, there are still some works and projects with certain limitations, the project must be adjusted many times; the volume, unit price, and norms applied are not appropriate; projects that are completed late, handed over and put into use, or after they are put into use, quickly damaged or degraded buildings have not yet brought into full play their functions according to the set objectives, causing a waste of the state budget. This study points out the need to strengthen management, thereby proposing solutions for the management of investment projects using state budget capital to achieve high efficiency in the future.
Anglican Fasting and Prayer Society and Development of Christianity in Urhobo, 1990-2017
Authors: ONU Ben O. , Onokpite Freeborn Avwerosuoghene
Published: March 2022

The emergence of charismatic groups in mainline churches has infused new worship life and increase in membership and structure. The historiography of Anglican Fasting and Prayer Society, examined the characteristics and impact of the movement to the development of the Christian faith in Urhobo between 1990 and 2017. The functional theory which stressed on the role of religion in the society was adopted. Historical, phenomenological, participant observation, and oral interview methods were applied. Data were drawn from primary and secondary source to allow for unbiased analysis of findings. The movement, has affected the worship life of members which has led to the speedy growth and development of Anglican churches in Warri, Ughelli, and Sapele Dioceses. The rift between some leaders of the movement and authorities of the Anglican Church occasioned the founding of new churches which has expanded the Christian landscape in Urhobo. Wittingly or unwittingly, the movement has become a breeding ground for charismatic leaders and church founders in the area. The paper recommended for the sustenance of the movement; appointment of chaplains to each branch of AFPS and establishment of theological institution to empower members and promote balanced growth of the church. Further in-depth research on the churches that emerged from the movement will enrich our understanding of growth pattern of new generation churches in the Niger Delta, Nigeria, and Africa by extension.
“Pattern of Sexually Transmitted Infections: Treated in A Private Clinic at Dhaka, Bangladesh”
Authors: Rahman Md. Mahmudur , Haq Sharmina , Rashid Saida , Hossain Syeda Rubana
Published: March 2022

Background: Sexually transmitted infections (STIs), including human immunodeficiency virus (HIV), continue to present major health, social, and economic problems in the developing world, leading to considerable morbidity, mortality, stigma and long-term disability, economic loss and death throughout the world. Despite the availability of effective treatment and preventive measures, incidence of STIs is increasing even in developed countries. Objectives: To determine the pattern of sexually transmitted infections in patients presenting with genital symptoms. Material and Methods: A cross sectional, descriptive study was carried in the Dermatology-Venereology Clinic of Holy Lab Diagnostic & Consultation Centre, Uttara, Dhaka, Bangladesh from January to December 2019. During one year period, a total of 140 consecutive cases were enrolled in this study. The diagnosis of infections was made clinically with relevant laboratory investigations and they were interviewed for their sexual behaviour after taking consent and assuring confidentiality. Results: A total of one hundred forty (140) patients who presented with genital symptoms were studied. The average age of this population was 28.84 years (±9.15) and it ranged from 18-58 years. 3.7% belonged to age group 18-27 years, followed by 28-37 years (22.1%); 38-47 yrs (52.8%); 48-57 yrs (18.5%) and > 57 yrs (2.8%). Majority patients of 38-47 yrs 74 cases 52.8%. Males outnumbered females, constituting 76.2% of the total patients, with male to female ratio of 3.37:1. Out of the total 140, some had multiple complaints while others were asymptomatic. Majority cases of burning micturition in both male and female patients 39(24%). Burning micturition and discharge from genitalia was also observed in both sexes. The most frequently encountered infection in both male and female was Gonococcal Urethritis (GU) 42 (30%). The infections were common among both married and unmarried people. Other group of people who had no STI (23.5%) was suffering from venereophobia, pearly penile papules and some form of dermatitis. No case of HIV infection was encountered in this study. Gonococcal Urethritis was common mainly among businessman, transportation worker, security personnel and housewives. Other infections were equally dispersed in all other occupation groups. Conclusions: The prevention and control of STI is based on health education, appropriate diagnosis and treatment. Sexually active people adolescents and young adults should be provided with proper sex education about delaying sex debut and protective measures (correct and consistent use of barrier method during every sexual act) to prevent these infections with especial focus on monogamous relationship.