bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of Adhesion of Geopolymer and Varnished Coatings by the Pull-Off Method
Authors: Łach Michał , Róg Gabriela , Ochman Karolina , Pławecka Kinga , Bąk Agnieszka , Korniejenko Kinga
Published: January 2022

This paper presents the results of testing the adhesion of geopolymer coatings and varnishes with ceramic additives to concrete and steel substrates. The measurement method used and described in this article was the pull-off method. The pull-off method test provides an easy way to evaluate the degree of adhesion of coatings to metal surfaces. The pull-off device provides values for the peel stress, which not only allows a quick determination of the adhesion of the coating to the substrate, but also makes it easier to compare the adhesion of several coatings to each other. However, this method requires appropriate preparation, so an attempt was made to determine its suitability for geopolymer layers. The results of testing the adhesion of a geopolymer layer to a geopolymer substrate and a concrete substrate are presented. As a result of this study, a higher adhesion strength of the geopolymer layer to the geopolymer substrate was found in comparison to geopolymer coatings applied on conventional concrete. Adhesion tests were also conducted for steel substrates to which both geopolymer and acrylic lacquer were applied.
Propagation and Transformation of Vortexes in Linear and Nonlinear Radio-Photon Systems
Authors: Bagmanov Valery , Sultanov Albert , Meshkov Ivan , Gizatulin Azat , Nigmatullin Raoul , Sakhabutdinov Airat
Published: January 2022

The article is devoted to issues related to the propagation and transformation of vortexes in the optical range of frequency. Within the framework of the traditional and modified model of slowly varying envelope approximation (SVEA), the process of converting vortex beams of the optical domain into vortex beams of the terahertz radio range based on nonlinear generation of a difference frequency in a medium with a second-order susceptibility is considered. The modified SVEA splits a slowly varying amplitude into two factors, which makes it possible to more accurately describe the three-wave mixing process. The theoretical substantiation of the rule of vortex beams topological charges conversion is given—the topological charge of the output radio-vortex beam is equal to the difference between the topological charges of the input optical vortex beams. A numerical simulation model of the processes under consideration has been implemented and analyzed.
The Early Immune Response of Lymphoid and Myeloid Head-Kidney Cells of Rainbow Trout (Oncorhynchus mykiss) Stimulated with Aeromonas salmonicida
Authors: Sarais Fabio , Montero Ruth , Ostermann Sven , Rebl Alexander , Köllner Bernd , Goldammer Tom
Published: January 2022

The teleost head kidney is a highly relevant immune organ, and myeloid cells play a major role in this organ’s innate and adaptive immune responses. Because of their complexity, the early phases of the innate immune reaction of fish against bacteria are still poorly understood. In this study, naïve rainbow trout were stimulated with inactivated A. salmonicida and sampled at 12 h, 24 h and 7 d poststimulation. Cells from the head kidney were magnetically sorted with a monoclonal antibody mAB21 to obtain one (MAb21-positive) fraction enriched with myeloid cells and one (MAb21-negative) fraction enriched with lymphocytes and thrombocytes. The gene expression pattern of the resulting cell subpopulations was analysed using a panel of 43 immune-related genes. The results show an overall downregulation of the complement pathway and cytokine production at the considered time points. Some of the selected genes may be considered as parameters for diagnosing bacterial furunculosis of rainbow trout.
Characterization of the Flavor Profile of Bigeye Tuna Slices Treated by Cold Plasma Using E-Nose and GC-IMS
Authors: Pan Weicong , Benjakul Soottawat , Sanmartin Chiara , Guidi Alessandra , Ying Xiaoguo , Ma Lukai , Weng Xudong , Yu Jin , Deng Shanggui
Published: January 2022

To avoid heat, treatment induces numerous physicochemical changes under severe conditions in the tuna, cold plasma (CP), as a non-thermal technology, possess objective potential on tuna processing. The effect of cold plasma on the volatile flavor compounds of bigeye tuna (Thunnus obesus) sashimi has been evaluated using electronic nose (E-nose) and gas chromatography-ion mobility spectrometry (GC-IMS). GC–IMS results revealed a total of 33 volatile compounds in tuna slices. The effect of CP treatment on tuna flavor was not significant, furthermore CP could protect volatile freshness compounds such as 1-hexanol. Principal component analysis (PCA) of the E-nose and GC–IMS results could effectively differentiate the effect of storage to tuna sashimi. There was a high correlation between the E-nose and GC–IMS results, providing a theoretical basis for establishing the flavor fingerprint of tuna sashimi.
A Monolithic Finite Element Formulation for Magnetohydrodynamics Involving a Compressible Fluid
Authors: Gupta Adhip , Jog C. S.
Published: January 2022

This work develops a new monolithic finite-element-based strategy for magnetohydrodynamics (MHD) involving a compressible fluid based on a continuous velocity–pressure formulation. The entire formulation is within a nodal finite element framework, and is directly in terms of physical variables. The exact linearization of the variational formulation ensures a quadratic rate of convergence in the vicinity of the solution. Both steady-state and transient formulations are presented for two- and three-dimensional flows. Several benchmark problems are presented, and comparisons are carried out against analytical solutions, experimental data, or against other numerical schemes for MHD. We show a good coarse-mesh accuracy and robustness of the proposed strategy, even at high Hartmann numbers.
Developing Qualitative Plasmid DNA Reference Materials to Detect Mechanisms of Quinolone and Fluoroquinolone Resistance in Foodborne Pathogens
Authors: Niu Qinya , Su Xiumin , Lian Luxin , Huang Jinling , Xue Shutong , Zhou Wei , Zhao Hongyang , Lu Xing’an , Cui Shenghui , Chen Jia , Yang Baowei
Published: January 2022

The aim of this study was to develop homogeneous and stable plasmid DNA reference materials for detecting the mechanisms of resistance to quinolones and fluoroquinolones in foodborne pathogens. The DNA fragments of 11 target genes associated with quinolone and fluoroquinolone resistance were artificially synthesized, inserted into plasmid vectors, and transferred into recipient cells. PCR and sequencing of DNA were performed to assess the genetic stability of the target DNA in recombinant Escherichia coli DH5α cells during subculturing for 15 generations. The limit of detection (LOD) of the target DNA was determined using PCR and real-time qualitative PCR (qPCR). The homogeneity and storage stability of plasmid DNA reference materials were evaluated in terms of plasmid DNA quantity, PCR-measured gene expression, and qPCR threshold cycle. All 11 target DNAs were successfully synthesized and inserted into vectors to obtain recombinant plasmids. No nucleotide mutations were identified in the target DNA being stably inherited and detectable in the corresponding plasmids during subculturing of recombinant strains. When the target DNA was assessed using PCR and qPCR, the LOD was ≤1.77 × 105 and 3.26 × 104 copies/μL, respectively. Further, when the reference materials were stored at 37 °C for 13 days, 4 °C for 90 days, and −20 °C for 300 days, each target DNA was detectable by PCR, and no mutations were found. Although the threshold cycle values of qPCR varied with storage time, they were above the LOD, and no significant differences were found in the quantity of each plasmid DNA at different timepoints. Further, the homogeneity and stability of the materials were highly consistent with the requirements of standard reference materials. To summarize, considering that our plasmid DNA reference materials conformed to standard requirements, they can be used to detect the mechanisms of quinolone and fluoroquinolone resistance in foodborne pathogens.
Chemical Characterization of Different Products from the Tunisian Opuntia ficus-indica (L.) Mill.
Authors: Albergamo Ambrogina , Potortí Angela Giorgia , Di Bella Giuseppa , Amor Nawres Ben , Lo Vecchio Giovanna , Nava Vincenzo , Rando Rossana , Ben Mansour Hedi , Lo Turco Vincenzo
Published: January 2022

Various dried (by-)products from the Tunisian O. ficus-indica were elucidated for their proximate composition, fatty acid (FA) composition, inorganic elements, sugars, and polyphenols. Nopal and prickly pear peel and seeds were abundant in fiber (respectively, 28.39, 12.54, and 16.28%). Seeds had also high protein (17.34%) and may be source of an edible oil, due to lipids (9.65%) poor in saturated FAs (14.12%) and rich in linoleic acid (61.11%). Nopal and peel showed the highest levels of Mg (493.57 and 345.19 mg/100 g), K (6949.57 and 1820.83 mg/100 g), Mn (59.73 and 46.86 mg/Kg) and Fe (23.15 and 15.23 mg/Kg), while the fruit pulp predominantly constituted of sugars, glucose and arabinose being predominant (42.57 and 13.56 g/100 g). Total polyphenols widely varied among the Opuntia products (108.36–4785.36 mg GAE/100 g), being mainly represented by hydroxycinnamic and hydroxybenzoic acids, and flavonoids as well. In particular, peel may be revalorized for these valuable bioactives, including 4-hydroxybenzoic acid (484.95 mg/100 g), cinnamic acid (318.95 mg/100 g), rutin (818.94 mg/100 g), quercetin (605.28 mg/100 g), and several isorhamnetin and kaempferol glycosides. Overall, the Tunisian prickly pear cactus could encourage a sustainable production, an effective waste management, and may provide several benefits for human health, in accordance with the model of the Mediterranean diet.
Influence of Salting Technology on the Diffusion of NaCl in Swordfish (Xiphias gladius) Fillets
Authors: Corrias Francesco , Scano Efisio , Sarais Giorgia , Angioni Alberto
Published: January 2022

Swordfish is the most widespread billfish in the aquatic environment. The industrial processing of swordfish fillets involves salting, drying, and smoking steps. Salting techniques, dry or wet, are the most common method of fish preservation. This work evaluated salt diffusion in swordfish fillets after traditional dry salting and wet industrial injection salting methods. The data obtained from the dry salting studies highlighted that the salt diffusion process in swordfish meat was an unfavorable process depending on the contact time with the salt/meat. Moreover, irregularly shaped fillets negatively affected the salt migration in the different areas, leading to inhomogeneous and possibly unsafe final products. On the contrary, wet injection salting was suitable for processing swordfish fillets. As a result, the final products had a homogeneous salt concentration, maintained the organoleptic characteristics and health benefits for a long period, and achieved a longer shelf-life. Furthermore, the water activity (aw) values detected for the different processed fillets confirmed the physicochemical features of the final products and allow the classification of safe products. Moreover, injection salting is a quick process compatible with industrial production times.
Effects of Baicalein and Chrysin on the Structure and Functional Properties of β-Lactoglobulin
Authors: Li Ang , Chen Lei , Zhou Weijie , Pan Junhui , Gong Deming , Zhang Guowen
Published: January 2022

Two flavonoids with similar structures, baicalein (Bai) and chrysin (Chr), were selected to investigate the interactions with β-lactoglobulin (BLG) and the influences on the structure and functional properties of BLG by multispectral methods combined with molecular docking and dynamic (MD) simulation techniques. The results of fluorescence quenching suggested that both Bai and Chr interacted with BLG to form complexes with the binding constant of the magnitude of 105 L·mol−1. The binding affinity between BLG and Bai was stronger than that of Chr due to more hydrogen bond formation in Bai–BLG binding. The existence of Bai or Chr induced a looser conformation of BLG, but Chr had a greater effect on the secondary structure of BLG. The surface hydrophobicity and free sulfhydryl group content of BLG lessened due to the presence of the two flavonoids. Molecular docking was performed at the binding site of Bai or Chr located in the surface of BLG, and hydrophobic interaction and hydrogen bond actuated the formation of the Bai/Chr–BLG complex. Molecular dynamics simulation verified that the combination of Chr and BLG decreased the stability of BLG, while Bai had little effect on it. Moreover, the foaming properties of BLG got better in the presence of the two flavonoids compounds and Bai improved its emulsification stability of the protein, but Chr had the opposite effect. This work provides a new idea for the development of novel dietary supplements using functional proteins as flavonoid delivery vectors.
Inhibitory Mechanism of Baicalein on Acetylcholinesterase: Inhibitory Interaction, Conformational Change, and Computational Simulation
Authors: Liao Yijing , Hu Xing , Pan Junhui , Zhang Guowen
Published: January 2022

Alzheimer’s disease (AD) is the most prevalent chronic neurodegenerative disease in elderly individuals, causing dementia. Acetylcholinesterase (AChE) is regarded as one of the most popular drug targets for AD. Herbal secondary metabolites are frequently cited as a major source of AChE inhibitors. In the current study, baicalein, a typical bioactive flavonoid, was found to inhibit AChE competitively, with an associated IC50 value of 6.42 ± 0.07 µM, through a monophasic kinetic process. The AChE fluorescence quenching by baicalein was a static process. The binding constant between baicalein and AChE was an order of magnitude of 104 L mol−1, and hydrogen bonding and hydrophobic interaction were the major forces for forming the baicalein−AChE complex. Circular dichroism analysis revealed that baicalein caused the AChE structure to shrink and increased its surface hydrophobicity by increasing the α-helix and β-turn contents and decreasing the β-sheet and random coil structure content. Molecular docking revealed that baicalein predominated at the active site of AChE, likely tightening the gorge entrance and preventing the substrate from entering and binding with the enzyme, resulting in AChE inhibition. The preceding findings were confirmed by molecular dynamics simulation. The current study provides an insight into the molecular-level mechanism of baicalein interaction with AChE, which may offer new ideas for the research and development of anti-AD functional foods and drugs.
Improvement of Gel Quality of Squid (Dosidicus gigas) Meat by Using Sodium Gluconate, Sodium Citrate, and Sodium Tartrate
Authors: Chu Yanjiao , Deng Shanggui , Lv Guancheng , Li Mingao , Bao Hongli , Gao Yuanpei , Jia Ru
Published: January 2022

In order to improve the quality of squid surimi products, squid surimi gels were prepared using several types of organic salts under two heating conditions to study the effects of organic salts on squid gel properties. Compared with the NaCl group, organic salts reduced the solubilization capacity of myofibrillar protein, and significant (p < 0.05) decreases in the breaking force, breaking distance, texture, and water-holding capacity of the gel were observed in the sodium gluconate group, while significant (p < 0.05) increases in the breaking force, breaking distance, texture, and water-holding capacity of the gel were observed in the sodium citrate and sodium tartrate groups. Although the mixed addition of NaCl and organic salt improved surimi gel quality, the effective improvement was still lower than that of only organic salt. Rheological properties indicated that sodium citrate and sodium tartrate had high viscoelasticity. The squid surimi gel prepared by direct heating exhibited better properties than gels prepared by two-step heating. The chemical force of squid gel prepared with sodium citrate and sodium tartrate formed a stronger matrix than the gels prepared with other salts. For color, the addition of sodium citrate resulted in an undesirable color of squid surimi gels, while the addition of sodium tartrate improved the whiteness of the surimi gel. The results showed that the quality of surimi gel was dependent upon the choice of heating method and the types of salt used. Sodium citrate and sodium tartrate could significantly improve the gel properties of squid surimi. This study provides reliable guidance for improving the overall quality of squid surimi gels.
Extraction, Purification and In Vitro Antioxidant Activity Evaluation of Phenolic Compounds in California Olive Pomace
Authors: Zhao Hefei , Avena-Bustillos Roberto J. , Wang Selina C.
Published: January 2022

Olive pomace (OP) is a valuable food byproduct that contains natural phenolic compounds with health benefits related to their antioxidant activities. Few investigations have been conducted on OP from the United States while many studies on European OP have been reported. OP of Arbequina, the most common cultivar from California, was collected and extracted by water, 70% methanol and 70% ethanol, followed by purification using macroporous absorbing resin. Results showed that the extractable total phenolic content (TPC) was 36–43 mg gallic acid equivalents (GAE)/g in pitted, drum-dried defatted olive pomace (DOP), with major contributions from hydroxytyrosol, oleuropein, rutin, verbascoside, 4-hydroxyphenyl acetic acid, hydroxytyrosol-glucoside and tyrosol-glucoside. Macroporous resin purification increased TPC by 4.6 times the ethanol crude extracts of DOP, while removing 37.33% total sugar. The antioxidant activities increased 3.7 times Trolox equivalents (TrE) by DPPH and 4.7 times TrE by ferric reducing antioxidant power (FRAP) in the resin purified extracts compared to the ethanol crude extracts. This study provided a new understanding of the extraction of the bioactive compounds from OP which could lead to practical applications as natural antioxidants, preservatives and antimicrobials in clean-label foods in the US.
Efficient Approaches for Solving Systems of Nonlinear Time-Fractional Partial Differential Equations
Authors: Ali Hegagi Mohamed , Ahmad Hijaz , Askar Sameh , Ameen Ismail Gad
Published: January 2022

In this work, we present a modified generalized Mittag–Leffler function method (MGMLFM) and Laplace Adomian decomposition method (LADM) to get an analytic-approximate solution for nonlinear systems of partial differential equations (PDEs) of fractional-order in the Caputo derivative. We apply the MGMLFM and LADM on systems of nonlinear time-fractional PDEs. Precisely, we consider some important fractional-order nonlinear systems, namely Broer–Kaup (BK) and Burgers, which have found major significance because they arise in many physical applications such as shock wave, wave processes, vorticity transport, dispersal in porous media, and hydrodynamic turbulence. The analysis of these methods is implemented on the BK, Burgers systems and solutions have been offered in a simple formula. We show our results in figures and tables to demonstrate the efficiency and reliability of the used methods. Furthermore, our outcome converges rapidly to the given exact solutions.
Identification and Control of Game-Based Epidemic Models
Authors: Madeo Dario , Mocenni Chiara
Published: January 2022

The effectiveness of control measures against the diffusion of the COVID-19 pandemic is grounded on the assumption that people are prepared and disposed to cooperate. From a strategic decision point of view, cooperation is the unreachable strategy of the Prisoner’s Dilemma game, where the temptation to exploit the others and the fear of being betrayed by them drives the people’s behavior, which eventually results in a fully defective outcome. In this work, we integrate a standard epidemic model with the replicator equation of evolutionary games in order to study the interplay between the infection spreading and the propensity of people to be cooperative under the pressure of the epidemic. The developed model shows high performance in fitting real measurements of infected, recovered and dead people during the whole period of COVID-19 epidemic spread, from March 2020 to September 2021 in Italy. The estimated parameters related to cooperation result to be significantly correlated with vaccination and screening data, thus validating the model. The stability analysis of the multiple steady states present in the proposed model highlights the possibility to tune fundamental control parameters to dramatically reduce the number of potential dead people with respect to the non-controlled case.
On the Polarisation of Radio Relics
Authors: Hoeft Matthias , Rajpurohit Kamlesh , Wittor Denis , di Gennaro Gabriella , Domínguez-Fernández Paola
Published: January 2022

Radio relics are extended radio emission features which trace shock waves in the periphery of galaxy clusters originating from cluster mergers. Some radio relics show a highly polarised emission, which make relics an excellent probe for the magnetisation of the intra-cluster medium. The origin of the relic polarisation is still debated. It could be a result of tangentially stretching the magnetic field at the shock surface. This scenario would naturally explain the alignment of the polarisation (E-vectors) with the shock normal. We have implemented a toy model for the relic polarisation according to this scenario. We find that the magnetic field strength itself crucially affects the fractional polarisation. Moreover, we find that the shock strength has surprisingly little effect on the overall polarisation fraction. Finally, we find that the fractional polarisation may decrease downstream depending on the magnetic field strength. Our results demonstrates that the shock compression scenario provides a very plausible explanation for the radio relic polarisation which specific features permitting to test the origin of radio relic polarisation.
Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application
Authors: Liu Sihang , Tang Jingyi , Ji Fangqin , Lin Weifeng , Chen Shengfu
Published: January 2022

Nonspecific protein adsorption impedes the sustainability of materials in biologically related applications. Such adsorption activates the immune system by quick identification of allogeneic materials and triggers a rejection, resulting in the rapid failure of implant materials and drugs. Antifouling materials have been rapidly developed in the past 20 years, from natural polysaccharides (such as dextran) to synthetic polymers (such as polyethylene glycol, PEG). However, recent studies have shown that traditional antifouling materials, including PEG, still fail to overcome the challenges of a complex human environment. Zwitterionic materials are a class of materials that contain both cationic and anionic groups, with their overall charge being neutral. Compared with PEG materials, zwitterionic materials have much stronger hydration, which is considered the most important factor for antifouling. Among zwitterionic materials, zwitterionic hydrogels have excellent structural stability and controllable regulation capabilities for various biomedical scenarios. Here, we first describe the mechanism and structure of zwitterionic materials. Following the preparation and property of zwitterionic hydrogels, recent advances in zwitterionic hydrogels in various biomedical applications are reviewed.
The Influence of Edible Oils’ Composition on the Properties of Beeswax-Based Oleogels
Authors: Frolova Yuliya , Sarkisyan Varuzhan , Sobolev Roman , Makarenko Mariia , Semin Michael , Kochetkova Alla
Published: January 2022

This study aimed to find relationships between the properties of beeswax-based oleogels and the type of oil used. The influence of linseed, sunflower, olive, and fish oils was studied. For these oils, the fatty acid composition, the content of total polar components, and the iodine value were characterized. Textural and thermodynamic properties were determined for oleogels, the oil-binding capacity was estimated, and the morphology of crystals was studied. The concentration of beeswax in all oleogels was 6.0% w/w. It was shown that the type of oil has a significant influence on all characteristics of the oleogels. The use of different oils at the same technological treatment leads to the formation of crystals of diverse morphology—from platelets to spherulites. At the same time, it was revealed that some characteristics of oils have a varying contribution to the properties of oleogels. The content of total polar materials in oils is associated with a decrease in strength parameters (yield value and elastic modulus) and the oil-binding capacity of oleogels. In its turn, the iodine value of oils has a close positive correlation with the melting and crystallization temperatures of oleogels. The results obtained in this article indicate that the properties of beeswax-based oleogels can be directed by changing the oil composition.
Symbols of the New Districts in Ukraine: Chervonohrad Raion as an Example
Authors: Grechylo Andriy
Published: January 2022

The article examines the beginning of the creation of symbols for the new raions (districts). In 2020, Ukraine underwent an administrative reform to merge most of the existing 490 districts, resulting in the creation of 136 new raions. We have proposed three options for solving the problems with the coats of arms and flags of the new districts. The practical implementation of these methodological developments is considered in the example of the Chervonohrad raion (the Lviv region). The symbols of this district were developed and approved in the summer of 2021. They managed to combine the symbols of the ancient historical land, and the current administrative center, and the old districts.
Finite-Element Modeling of Spontaneous Potential in an Axisymmetric Reservoir Model with Account of Its Shale Content
Authors: Epov Mikhail , Glinskikh Anastasia , Nechaev Oleg
Published: January 2022

(1) This article is devoted to the development of a theoretical and algorithmic basis for numerical modeling of the spontaneous potential method (SP) as applied to the study of sandy-argillaceous reservoirs. (2) In terms of coupled flows, we consider a physical–mathematical model of SP signals from an electrochemical source, with regards to the case of fluid-saturated shaly sandstone. (3) An algorithm for 2D finite-element modeling of SP signals was developed and implemented in software, along with its internal and external testing with analytical solutions. The numerical SP modeling was carried out, determining the dependences on the reservoir thickness and porosity, the amount of argillaceous material and the type of minerals. We performed a comparative analysis of the simulated and field SP data, using the results of laboratory core examinations taken from wells in a number of fields in the Latitudinal Ob Region of Western Siberia. (4) The results of the study may be used either for the development of the existing SP techniques, by providing them with a consistent computational model, or for the design of new experimental approaches.
Lessons Learned: Occupational Therapy in Nursing Homes during the First Wave of COVID-19 in Spain
Authors: Chimento-Díaz Sara , Espino-Tato Isabel , Garcia-Alonso Jose M. , Cantero-Garlito Pablo A.
Published: January 2022

This research aims to explore the perception that occupational therapists working in elderly care facilities have about the measures implemented against the COVID-19 pandemic in their resources, and the impact that these measures have had on occupational therapy in these facilities. An interpretive paradigm was selected, using a qualitative approach and a phenomenological design. Sixteen occupational therapists working in elderly care facilities in two Spanish regions were included. Data were collected through semi-structured interviews. A discourse analysis of the narrative information was carried out using open, axial, and selective coding processes and the constant comparison method. Four themes were extracted from the analysis results: The initial chaos in senior centers; The blurring of occupational therapists’ roles; The emergence of technology; and organizational and therapeutic proposals for future pandemics. The pandemic had a significant impact on the care and therapeutic processes in elderly care facilities. Occupational therapists had to stop performing their functions to dedicate themselves to other support, auxiliary or communication tasks between the center and the families. Similarly, it is worth noting the emergence of low-cost technology to facilitate communication and to carry out some therapeutic interventions.
Resource Utilization and Caring Cost of People Living with Human Immunodeficiency Virus (PLHIV) in Saudi Arabia: A Tertiary Care University Hospital Experience
Authors: Barry Mazin , Ghonem Leen , Albeeshi Nourah , Alrabiah Maha , Alsharidi Aynaa , Al-Omar Hussain Abdulrahman
Published: January 2022

The human immunodeficiency virus (HIV) is associated with a significant burden of disease, including medical and non-medical costs. Therefore, it is considered to be a priority for all health authorities. The aim of this study is to determine healthcare and treatment costs of caring for PLHIV at one of the tertiary care university hospitals in Riyadh, Saudi Arabia. This was a micro-costing, retrospective, observational study from a tertiary care university hospital and included all confirmed HIV-infected patients who visited infectious disease clinics in the period from 1 January 2015 to 31 December 2018. A total of 42 PLHIV were included in this study. The mean age of the study participants was 38.76 ± 11.47 years with a mean disease duration of 5.27 ± 4.81 years. The majority of patients were male (85.7%) and Saudi (88.1%). More than half of included patients (59.5%) had a CD4 count of more than 500. During the study period, 26 patients (61.9%) were initiated on a single-tablet regimen. Overall, the main cost-driver was antiretroviral medications, which cumulatively represented more than 64% of the total cost. Patients who developed opportunistic infections had a statistically significant (p = 0.033) higher financial impact, both as a total and on a patient level, than those presented without opportunistic infections. On a patient level, the mean and median costs were higher and statistically significant for those with co-morbidities than those without co-morbidities (p = 0.002). The majority of the economic burden of PLHIV is attributable to antiretroviral therapy use. The healthcare costs of PLHIV can vary greatly, depending on the presenting illness, clinical stage, developed opportunistic infection, co-morbidity, and pharmacological therapy.
Association between Kinesiophobia and Knee Pain Intensity, Joint Position Sense, and Functional Performance in Individuals with Bilateral Knee Osteoarthritis
Authors: Alshahrani Mastour Saeed , Reddy Ravi Shankar , Tedla Jaya Shanker , Asiri Faisal , Alshahrani Adel
Published: January 2022

In current clinical practice, fear of movement has been considered a significant factor affecting patient disability and needs to be evaluated and addressed to accomplish successful rehabilitation strategies. Therefore, the study aims (1) to establish the association between kinesiophobia and knee pain intensity, joint position sense (JPS), and functional performance, and (2) to determine whether kinesiophobia predicts pain intensity, JPS, and functional performance among individuals with bilateral knee osteoarthritis (KOA). This cross-sectional study included 50 participants (mean age: 67.10 ± 4.36 years) with KOA. Outcome measures: The level of kinesiophobia was assessed using the Tampa Scale of Kinesiophobia, pain intensity using a visual analog scale (VAS), knee JPS using a digital inclinometer, and functional performance using five times sit-to-stand test. Knee JPS was assessed in target angles of 15°, 30°, and 60°. Pearson’s correlation coefficients and simple linear regressions were used to analyze the data. Significant moderate positive correlations were observed between kinesiophobia and pain intensity (r = 0.55, p < 0.001), JPS (r ranged between 0.38 to 0.5, p < 0.05), and functional performance (r = 0.49, p < 0.001). Simple linear regression analysis showed kinesiophobia significantly predicted pain intensity (B = 1.05, p < 0.001), knee JPS (B ranged between 0.96 (0° of knee flexion, right side) to 1.30 (15° of knee flexion, right side)), and functional performance (B = 0.57, p < 0.001). We can conclude that kinesiophobia is significantly correlated and predicted pain intensity, JPS, and functional performance in individuals with KOA. Kinesiophobia is a significant aspect of the recovery process and may be taken into account when planning and implementing rehabilitation programs for KOA individuals.
Care of Transgender Patients: A General Practice Quality Improvement Approach
Authors: Boyd Isabel , Hackett Thomas , Bewley Susan
Published: January 2022

Primary care must ensure high quality lifelong care is offered to trans and gender minority patients who are known to have poor health and adverse healthcare experiences. This quality improvement project aimed to interrogate and audit the data of trans and gender minority patients in one primary care population in England. A new data collection instrument was created examining pathways of care, assessments and interventions undertaken, monitoring, and complications. General practitioners identified a sample from the patient population and then performed an audit to examine against an established standard of care. No appropriate primary care audit standard was found. There was inconsistency between multiple UK gender identity clinics’ (GIC) individual recommended schedules of care and between specialty guidelines. Using an international, secondary care, evidence-informed guideline, it appeared that up to two-thirds of patients did not receive all recommended monitoring standards, largely due to inconsistencies between GIC and international guidance. It is imperative that an evidence-based primary care guideline is devised alongside measurable standards. Given the findings of long waits, high rates of medical complexity, and some undesired treatment outcomes (including a fifth of patients stopping hormones of whom more than half cited regret or detransition experiences), this small but population-based quality improvement approach should be replicated and expanded upon at scale.
The Severity of Postoperative Pancreatic Fistula Predicts 30-Day Unplanned Hospital Visit and Readmission after Pancreaticoduodenectomy: A Single-Center Retrospective Cohort Study
Authors: Kou Hao-Wei , Hsu Chih-Po , Chen Yi-Fu , Huang Jen-Fu , Chang Shih-Chun , Lee Chao-Wei , Wang Shang-Yu , Yeh Chun-Nan , Yeh Ta-Sen , Hwang Tsann-Long , Hsu Jun-Te
Published: January 2022

Background: Unplanned hospital visits (UHV) and readmissions after pancreaticoduodenectomy (PD) impact patients’ postoperative recovery and are associated with increased financial burden and morbidity. The aim of this study is to identify predictive factors related to these events and target the potentially preventable UHV and readmissions. Methods: We enrolled 518 patients in this study. Characteristics were compared between patients with or without UHV and readmissions. Results: The unplanned visit and readmission rate was 23.4% and 15.8%, respectively. Postoperative pancreatic fistula (POPF) grade B or C, the presence of postoperative biliary drainage, and reoperation were found to be predictive factors for UHV, whereas POPF grade B or C and the presence of postoperative biliary drainage were independently associated with hospital readmission. The most common reason for readmission was an infection, followed by failure to thrive. The overall mortality rate in the readmission group was 4.9%. Conclusions: UHV and readmissions remain common among patients undergoing PD. Patients with grade B or C POPF assessed during index hospitalization harbor an approximately two-fold increased risk of subsequent unplanned visits or readmissions compared to those with no POPF or biochemical leak. Proper preventive strategies should be adopted for high-risk patients in this population to maintain the continuum of healthcare and improve quality.
Effectiveness of Physiotherapy in Patients with Ankylosing Spondylitis: A Systematic Review and Meta-Analysis
Authors: Gravaldi Luca Pontone , Bonetti Francesca , Lezzerini Simona , De Maio Fernando
Published: January 2022

This study aimed to evaluate the safety and effectiveness of non-pharmacological interventions supervised by a physiotherapist in patients with Ankylosing Spondylitis, PROSPERO Protocol number CRD42020209453. Five databases (PubMed, PEDro, Scopus, Web of Science Core, and EMBASE) and reference lists with relevant articles were searched. Randomised controlled trials (RCTs) on the effectiveness of non-pharmacological interventions supervised by a physiotherapist were compared with usual care or home-based exercise programmes. Two investigators independently screened eligible studies. A total of 12 RCTs satisfied eligible criteria. The risk of bias ranged between medium and high. The meta-analysis results indicated that between supervised physiotherapy and usual care, the former was significantly associated with improvement in disease activity (standardised mean difference = −0.37, 95% CI, −0.64; −0.11; p < 0.001, I2 = 71.25%, n = 629), and functional capacity (standardised mean difference = −0.36, 95% CI, −0.61; −0.12, p < 0.05; n = 629). No statistically significant differences emerged when interventions were compared with home-based exercise programmes. Supervised physiotherapy is more effective than usual care in improving disease activity, functional capacity, and pain in patients with ankylosing spondylitis. No significant improvements emerged when supervised physiotherapy and home-based exercise programmes were compared. Further investigation and RCTs with larger samples are needed.
Cyanobacteria: A Natural Source for Controlling Agricultural Plant Diseases Caused by Fungi and Oomycetes and Improving Plant Growth
Authors: Righini Hillary , Francioso Ornella , Martel Quintana Antera , Roberti Roberta
Published: January 2022

Cyanobacteria, also called blue-green algae, are a group of prokaryotic microorganisms largely distributed in both terrestrial and aquatic environments. They produce a wide range of bioactive compounds that are mostly used in cosmetics, animal feed and human food, nutraceutical and pharmaceutical industries, and the production of biofuels. Nowadays, the research concerning the use of cyanobacteria in agriculture has pointed out their potential as biofertilizers and as a source of bioactive compounds, such as phycobiliproteins, for plant pathogen control and as inducers of plant systemic resistance. The use of alternative products in place of synthetic ones for plant disease control is also encouraged by European Directive 2009/128/EC. The present up-to-date review gives an overall view of the recent results on the use of cyanobacteria for both their bioprotective effect against fungal and oomycete phytopathogens and their plant biostimulant properties. We highlight the need for considering several factors for a proper and sustainable management of agricultural crops, ranging from the mechanisms by which cyanobacteria reduce plant diseases and modulate plant resistance to the enhancement of plant growth.
Stream Stage Monitoring with Community Science-Contributed Stage Data
Authors: Luffman Ingrid , Connors Daniel
Published: January 2022

Volunteered Geographic Information, data contributed by community scientists, is an increasingly popular tool to collect scientific data, involve the community in scientific research, and provide information and education about a prominent issue. Johnson City, Tennnessee, USA has a long history of downtown flooding, and recent redevelopment of two land parcels has created new city parks that mitigate flooding through floodwater storage, additional channel capacity, and reduced impervious surfaces. At Founders Park, a project to collect stage data using text messages from community scientists has collected 1479 stage measurements from 597 participants from May 2017 through July 2021. Text messages were parsed to extract the stage and merged with local precipitation data to assess the stream’s response to precipitation. Of 1479 observations, 96.7% were correctly parsed. Only 3% of observations were false positives (parser extracted incorrect stage value) or false negatives (parser unable to extract correct value but usable data were reported). Less than 2% of observations were received between 11 p.m. and 7 a.m., creating an overnight data gap, and fewer than 7% of observations were made during or immediately following precipitation. Regression models for stage using antecedent precipitation explained 21.6% of the variability in stream stage. Increased participation and development of an automated system to record stage data at regular intervals will provide data to validate community observations and develop more robust rainfall–runoff models.
Transfer of Metal(loid)s from Soil to Leaves and Trunk Xylem Sap of Medicinal Plants and Possible Health Risk Assessment
Authors: Rosa Ana C. Gomes , Melo Elaine S. de Pádua , Junior Ademir S. A. , Gondim Jacqueline M. S. , de Sousa Alexsandro G. , Cardoso Claudia A. L. , Viana Lucilene F. , Carvalho Alexandra M. A. , Machate David J. , do Nascimento Valter Aragão
Published: January 2022

The objective of the present study was to investigate metal(loid)s in soils, in the trunk xylem sap and in the leaves of the Dipteryx alata plant located near the highway with high vehicle traffic in agricultural regions and near landfills, and to assess the transfer of metal(loid)s from soil to plant and possible health risk assessment. Trunk xylem sap, leaves and soil samples were collected at three sites near the highway. The analysis of trace elements was carried out using inductively coupled plasma optical emission spectroscopy (ICP OES). In the three soil sampling sites far from the highway edge, 15 elements were quantified. The concentrations of elements in the soil presented in greater proportions in the distance of 5 m in relation to 20 and 35 m. The metal(loid)s content in the study soil was higher than in other countries. The concentrations of Al, Cu, Fe, Mg, Mn, P, Se and Zn in the xylem sap were much higher than the leaves. The values of transfer factor of P, Mg and Mn from soil to the xylem sap and transfer factor of P from soil to leaf were greater than 1, indicating that the specie have a significant phytoremediation and phytoextraction potential. This plant has a tendency to accumulate As, Cd and Cr in its leaf tissues. The chronic hazard index (HI) values recorded in this study were above 1 for adults and adolescents. It is concluded that the soil, the trunk xylem sap and leaves of this plant are contaminated by heavy metals. Ingestion of the trunk xylem sap of this plant can cause toxicity in humans if ingested in large quantities and in the long term; therefore, its consumption should be avoided.
Key Components for the Delivery of Palliative and End-of-Life Care in Care Homes in Hong Kong: A Modified Delphi Study
Authors: Chan Helen Yue-Lai , Chan Cecilia Nim-Chee , Man Chui-Wah , Chiu Alice Dik-Wah , Liu Faith Chun-Fong , Leung Edward Man-Fuk
Published: January 2022

Integrating the palliative care approach into care home service to address the complex care needs of older adults with frailty or advanced diseases has been increasingly recognized. However, such a service is underdeveloped in Hong Kong owing to socio-cultural and legal concerns. We adopted a modified Delphi study design to identify the key components for the delivery of palliative and end-of-life care in care home settings for the local context. It was an iterative staged method to assimilate views of experts in aged care, palliative care, and care home management. A multidisciplinary expert panel of 18 members consented to participate in the study. They rated their level of agreement with 61 candidate statements identified through a scoping review in two rounds of anonymous surveys. The steering group revised the statements in light of the survey findings. Eventually, the finalized list included 28 key statements concerning structure and process of care in seven domains, namely policy and infrastructure, education, assessment, symptom management, communication, care for dying patients, and family support. The findings of this study underscored concerns regarding the feasibility of statements devised at different levels of palliative care development. This list would be instrumental for regions where the development of palliative and end-of-life care services in care home setting is at an initial stage.
Moderating Effects of Physical Activity on the Relationship between Adverse Childhood Experiences and Health-Related Quality of Life
Authors: Moon Ingyu , Han Junghee
Published: January 2022

The effects of adverse childhood experiences (ACEs) on health-related quality of life (HRQOL) and their associations with physical activities (PA) are well-documented. However, the specific effects of different types of ACEs (e.g., child abuse and household dysfunction) on HRQOL and the role of PA are inconclusive. The purpose of this study is to find the buffering role of PA as a moderator that may reduce the negative impact of ACEs in general and the specific effects of different types of ACEs on HRQOL, perceived physical health, and mental health over time. The 2019 Behavioral Risk Fact Surveillance System (BRFSS), a state-based surveillance system supported by the CDC in the U.S., was used for this study. A total of 127,370 respondents from 17 states were selected for this study. First, descriptive statistics were generated and correlation analyses were conducted to find the association among variables and examine the possible predictors of HRQOL. Moderation models were then tested using Structural Equation Modeling (SEM). HRQOL in adults is negatively associated with ACEs, but is positively associated with PA. We found buffering effects of physical activity in the following relationships: (1) child abuse and HRQOL, (2) child abuse and perceived physical health, (3) ACEs and perceived mental health, (4) child abuse and perceived mental health, and (5) household dysfunction and perceived mental health. Our findings suggest that improvement of PA level is a significant predictor of improved HRQOL of adults with ACEs.