bluuebunny/crossref_metadata_2025 huggingface dataset:
Peer Review Practices in Scientific Journals and Developmental Scholarship in South Africa: A Peer Reviewer Perspective
Authors: Sebola M. P.
Published: November 2021

The development of science starts with investment in human capital development. Thus far arguments are that it is innovation and development of science which can assure the country of good economic, political and social development. A continuous investment in the youth in academia is a necessity to foster and continue the requirement and continuity of the development of science in academia to advance the society developmentally. This article is conceptual in approach and uses secondary literature to argue that the goal to pursue developmental scholarship, does not only lie with incapacity to mentor, but also lie with the complex peer review system which should enable the emerging researchers with an opportunity to enter the publication space. Therefore, the methodological perspective of the article is purely qualitative and based on scientific materials explored to answer the research question raised in the article. This article concludes that the goal of achieving the next generation of researchers in both academia and practice shall require a system which is highly developmental through a well-developed system of mentoring within the academic environment.

 

Received: 19 August 2021 / Accepted: 6 October 2021 / Published: 5 November 2021
Practitioners and Uses of Contemporary Mende Folk literature in South-Eastern Sierra Leone
Authors: Fofanah Ibrahim Mustapha , Thulla Philip Foday Yamba , Moriba Samba
Published: November 2021

The study examined the practitioners and uses of contemporary Mende folk literature in South-eastern Sierra Leone. A qualitative research design involving 250 participants from 50 communities with 5 participants from each community was used in the study. Interviews were carried out using interview guide questions relating to folk practices, performance, and uses in the selected communities. Focus group discussions followed the interviews in 10 communities selected using simple random techniques. The findings revealed that Mende folk literature was endangered and, apart from occasional singing, household story-telling and riddling sessions done mainly by children and women, the only groups of people recognized as practitioners of Mende folk literature were the tribal and secret society heads and the community's griots, who mostly were elderly people. Mende folk literature should not only be of academic interest but rather a source of cultural rejuvenation.

 

Received: 26 July 2021 / Accepted: 27 September 2021 / Published: 5 November 2021
Evolution and Sustainability: What Is It Difference?
Authors: Martynov Arkady
Published: November 2021

This article is devoted to the fundamental interdisciplinary problems of evolution and sustainability. From a contemporary standpoint, the author assesses the persisting notions of social and, in particular, economic evolution. An appropriate alternative to these notions presents the framework concept of integrative sustainable development, enshrined in the UN Agenda 2030. Based on the recognized integrative vision of the sustainability problem, it is advisable to extend this concept to the entire process of transformation of society as a social system. It can be named sustainable overall social transformation (SOST). The fundamental properties of SOST and the role of key actors in its provision are revealed. As follows from the study, the current implementation of SOST will be largely associated with non-evolutionary changes. The final conclusion concerns the substantial difference between the sustainable and the preferable evolutionary trajectories of the overall social transformation in the long run.

 

Received: 4 August 2021 / Accepted: 6 October 2021 / Published: 5 November 2021
The Enactment and Critique of International Accounting Standard Two
Authors: Epizitone Ayogeboh , Nxumalo Samantha Cecilia
Published: November 2021

Harmonising the International Accounting Standards/International Financial Reporting Standards (IAS/IFRS) globally has been the objective of national boards that seek to eliminate existing differences. The harmonisation project has been substantially efficient in realising the IFRS in emerging economies. However, concerning the international accounting standard two, the existence of different inventory valuation methods in literature is one of the dilemmas confronting the application of IAS 2 in many nations globally. This study through a comprehensive literature review discusses and present a critique on the international accounting standard two to afford insight that will be beneficial to both scholar and standard setters. The findings reveal a formidable contribution of the current asset inventory on companies and compliance levels in South Africa.  Furthermore, these findings supplement prevailing body knowledge on IAS two and the value relevance of accounting inventories. Highlighting key critiques on the IAS 2 prescriptions and application internationally and also revealing the standards own crucial flaws and strengths and on companies.

 

Received: 6 May 2021 / Accepted: 23 August 2021 / Published: 5 November 2021
The COVID-2019 Pandemic as a Catalyst of the Potential Loss of Democratic Foundations of Society’s Social Life
Authors: Perskaya Victoria Vadimovna , Аbramov Valery Leonidovich , Pishchik Victor Yakovlevich , Alekseev Peter Viktorovich , Medvedeva Marina Borisovna , Khomyakova Lyubov Igorevna
Published: November 2021

The pandemic-2020 has come quite unexpectedly despite the repeated warnings from WHO. It turned out that the infection’s spread in all countries of the world and the new-how to resist it depends on the ability to mobilize national system of health protection. So, on the quality of the provided medical service, on the accessibility to all levels of the society and on the ability of countries’ governments to provide with proper regulation of social life self-isolation, on-line work and quarantine regimes became the most effective tools in the world. It demanded the appropriate control mostly based on new technological solutions. Remote work and the possibilities of modern technologies to track and identify people may get elaboration after the end of the pandemic-2020. There is a great possibility to lose a part of democratic freedom of society due to using new systems of social life control in order to increase countries functioning effectiveness as the main units of a polycentric model of the world order. It is emphasized that polycentrism should lead neither to the totalitarianism of power nor to the loss of democratization of social life. The government should promote this process by increasing the effectiveness of its activity not substituting it for total control based on ICT.

 

Received: 15 July 2021 / Accepted: 12 October 2021 / Published: 5 November 2021
Acting on Behalf of Another Without Consent as a Source of the Right of Obligations in the Republic of Kosovo
Authors: Morina Sevdai , Papajorgji Endri
Published: November 2021

In life, it often happens that humans take different actions on different occasions to save man or his wealth. These actions can be taken when there is a need to protect the integrity of man and his wealth, both individual and social wealth. Man performs these actions morally and without any institutional obligation. Man does the action without consent in order to save one's life or another's wealth. There is a need for such an action, because everyone sometimes in certain cases needs mutual help. With these behaviors of people, it is seen that they do not take these actions out of legal obligation, but act and should act with the consciousness and conscience of the civilized man. People who do this are driven by the need for cooperation, humanity, existence at the expense of the other, namely society. A person performs this action by perpetrating the work of another without consent for any other person. Hence, they undertake some factual and legal action for the other, sacrificing something that can be the property value and their bodily integrity. Sometimes this action must be taken because there are actions that cannot be postponed, therefore someone should take an action in such situations even when uninvited. Consequently, the subject matter analyzed in this paper is the act of perpetration of the work of another without consent as a source of the right of obligations in the Republic of Kosovo.

 

Received: 6 October 2021 / Accepted: 1 November 2021 / Published: 5 November 2021
The Efficiency of a Group Counselling Program Based on a Problem-Solving Strategy in Reducing Psychological Stress Among Adolescent Girls of Divorced Families
Authors: Al Ali Tagreed M. , Bataineh Omar T.
Published: November 2021

This study aimed to reveal the effect of a group counseling program based on a problem-solving strategy in reducing psychological stress among adolescent girls from divorced families. The study sample consisted of (30) students from children of divorced families, in the age group (13-16) years, enrolled in one of the public schools in Zarqa in the second semester 2018/2019. To achieve the objectives of the study, a quasi-experimental design was adopted, in which the sample was divided into two groups: an experimental group (n = 15), that was exposed to the counseling program, and a control group (n = 15) for whom the program was not presented. Both groups underwent a total of two sessions per week, in which the session duration ranged between (45-60) minutes. The results of the current study indicated that there were statistically significant differences between the average performance of the members of the experimental and control groups on the psychological stress test in its psychological, cognitive, and physiological dimensions in favor of the experimental group. This indicates the program’s efficiency in reducing psychological stresses. The study recommended developing more group counseling programs to address psychological, personal, social, and behavioral issues among adolescent girls and boys from divorced families.

 

Received: 5 July 2021 / Accepted: 2 September 2021 / Published: 5 November 2021
Brain-Based Online Learning Design in The Disruptive Era for Students in University
Authors: Kristanto Andi , Sulistiowati . , Pradana Hirnanda Dimas
Published: November 2021

The learning model is a collection of activities that occur during the teaching and learning process with the objective of achieving the set goals. The brain-based online learning model developed is a solution to the students' learning problems. The majority of students struggle to interpret all of the learning materials they receive. This resulted in students' dissatisfaction with the learning materials. The purpose of this research is to develop a brain-based online learning process design based on the aforementioned problems. The Lee & Owens model of development was used in this development research. The stages of the Lee & Owens development model are analysis, design, development, implementation, and evaluation. The development research findings are as follows: (1) the media experts' assessment, which resulted in an 89.35% score with a valid category. (2) The assessment of the developed learning materials by material experts resulted in a score of 91.23% with a valid category. (3) expert evaluation, with an overall score of 86.35% for having a valid category. (4) The results of individual trials produced a percentage score of 88.5% with a valid category. (5) The results of small group trials indicated an overall percentage score of 81.60% of valid categories. (6) Field trials are classified as valid when they receive a percentage of 79.89%. The results of the development indicate that the brain-based online learning design is feasible for use.

 

Received: 11 August 2021 / Accepted: 27 October 2021 / Published: 5 November 2021
Gender and Politics: Gender Balance as a Panacea to a Credible and Successful Election
Authors: Obinna Ogbonna Hyginus , Mbah Chidi Slessor , Imoudu Monica O.
Published: November 2021

This paper focuses on Gender Balance as a Panacea to a Credible and Successful Election, having as its raison d’être: to review the concept of gender balance and appropriate its implications towards achieving a credible and successful election required for the existence of human centered development process in sub-Saharan Africa, with Nigeria as a case study. Thus, the paper achieves its goal by adopting a qualitative descriptive method of analysis as it examines qualitatively: the urgency for the crusade on gender balance; the inter-linkages between gender balance and a credible-successful election. A few theoretical orientations were employed to mediate for a proper epistemic extrapolations and reconstructions to explaining gender balance as a panacea to a credible and successful election: these include, the notion of Social Contract, the notion of Democratic Culture, and the notion of Participatory Electoral Process. The paper made some findings, a few of these include: 1) there is the tendency in the sub-Saharan African socio-political cultural practice, Nigeria in particular, to socially exclude women in politics because the female gender has been judged first of all from sexuality point of view as a second class gender rather than seeing women, first of all, as humans, hence entitled to human rights for which right to political participation is inclusive. 2) There is a correlation between gender balance and a credible-successful election, and the absence of the former reproduces a negative outcome in the latter. The paper therefore concludes that strict observance of gender balance is a sine qua non for a credible-successful election conducive for human centered development process. It thus recommends for the total commitment of government to democratic culture by mainstreaming women in politics, inter alia.

 

Received: 27 July 2021 / Accepted: 15 October 2021 / Published: 5 November 2021
Address Forms in Turkish Culture as a Reflection of Social Status
Authors: Goktepe Fatma Tokoz
Published: November 2021

The study concerned itself with forms of communication and address in Turkish culture and seeks to study how they are today regarding how they have been developed historically. Many variables determine how one addresses another and the reasons behind how that forms are chosen. It is known that what is culturally acceptable and deemed polite varies across many different cultures, although some patterns are identical regardless of the culture in which they are exhibited. For the study, a survey was conducted upon several Turkish individuals, and the findings were analysed to extract specific themes and similarities in answers. The analysis was conducted via the Colaizzi method, in which a seven-step process was used to determine themes and recurring branches of themes in subjective interviews. The findings were reported upon and determined to correlate with what has been reported in previous literature on Turkish culture concerning social norms, forms of address and politeness.

 

Received: 10 September 2021 / Accepted: 12 October 2021 / Published: 5 November 2021
Efficacy of Ozone Gas against All Stages of Red Flour Beetle, Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae) at Different Temperatures and Exposure Periods
Authors: Al-Emara Mohammed S. , Alyousuf Aqeel A. , Abass Mohammed H.
Published: November 2021

Ozone efficacy (approximately of 600 Mg.hr-1) was evaluated against Red Flour Beetle’s (RFB, Tribolium castium (Herbst)) eggs, larvae, pupae and adults at different temperatures (35, 40 and 45 ° C) and exposure times (1, 2, 4, 6, 8, 10 hours) under laboratory. The control treatments included above thermal levels without ozone at the mentioned exposure periods. The results indicated ozone effectively suppressed hatching with increasing temperature. The hatch egg rates was reduced to 0 % in the treated treatments after 10 h at 45° C. However, mortality rates of RFB were increased with maximizing of the exposure time to ozone.  After 10-h exposure to ozone at the lowest temperature 35˚ C, complete mortality (100%) or few survivals of RFB were recorded in the susceptible stages (larvae and adults). Also, the complete mortality of adults and larvae resulted after an exposure to ozone at 40 ° C for 10 hours, compared than the high survival rates at the pest’s stages at 30 and 40° C, even after 10 hours of monitoring time. However the exposure time which is required to 100% mortality was decreased to 4 hours at 45 ° C, comparing to the thermal treatment only (control) which needed more time (6 h) for 100% of mortality. In conclusion, ozone application showed the efficacy on the mortality at all stages of RFB and the temperature was a potential factor enhancing the application of ozone for RFB control.
Outcome of Non-Invasive Ventilation in Patients of Acute Respiratory Failure.
Authors: Pal Anusmriti , Yadav Manoj Kumar , Pant Chiranjeevi
Published: November 2021

Introduction: Non-invasive ventilation (NIV) is a method of ventilator support or delivery of positive pressure into the lungs usually through a face mask, mostly initiated before severe acidosis occurs. NIV failure requiring invasive mechanical ventilation in decompensated chronic obstructive pulmonary disease (COPD) patients is low, but, in critical patients, it is as high as 60%. Acute respiratory failure (ARF) is the common reason for admission to the intensive care unit. This study assesses the outcome of NIV among patients with acute respiratory failure, the duration of use, stay in ICU, and failure rate of NIV. Such type of study result is scarce in our country.
Methods:  Arterial blood gases were assessed prior, after, and at discontinuation of NIV. NIV was delivered by ventilator via face mask. All patients above age 15 years who presented to the hospital, diagnosed to have ARF by ABG were included and admitted to Medical Intensive Care Unit (MICU). . Appropriate statistical tests (Chi-square) were performed and the statistical significance of the results was assessed.
Results: 35 patients with the median age of 73 years (range: 39- 89 years), of 60.0 % females among which 74.3 % were current smokers. Arterial blood pH prior to admission ranged from 7.11-7.39 and 7.06-7.41 among NIV success and failure, respectively. Similarly, PCo2 ranged from 54.0-127.5 and 29.5-105.9 among them, respectively. Two hours after ventilation pH ranged from 7.12-7.43 and 7.05-7.30 respectively in the success and failure group. The most common disease condition requiring NIV was 77.1% COPD.  Out of NIV failure group (n=19) ,57.8 % were intubated and 42.1% patients left the intervention. 
Conclusions: Usage of NIV among ARF patients was associated with lower intubation and ICU mortality rate. COPD patients showed the most benefit with NIV, whereas patients suffering from interstitial lung disease, lung cancer had less benefit.
Clinicopathological Characteristics and Surgical Findings of Epithelial Ovarian Carcinoma
Authors: Shakya Bemba , Shrestha Eliza , Dangal Ganesh
Published: November 2021

Introduction: Ovarian cancer was the third most common gynecological cancer globally in 2020. The objective of this study was to delineate clinicopathological characteristics and surgical findings of epithelial ovarian carcinoma in our context.

Methods: This is a descriptive cross-sectional study conducted at Bhaktapur Cancer Hospital, from March, 2023 to May, 2023. Ethical approval was obtained from Institutional Review Board (Ref. No. 773/2079/80). Data pertaining patient characteristics, initial symptoms, pre-operative CA-125 level, risk of malignancy index, stage, histology, type and extent of surgery and residual disease were evaluated in 35 cases of epithelial ovarian carcinoma. Data were analyzed using SPSS version 16.0.

Results: Among 35 cases of epithelial ovarian carcinoma, majority occurred in postmenopausal women (57.1%) with mean age 53 years. The most common presentation was abdominal distension (51.4%). Majority of patients had raised preoperative serum CA-125 level (94.2%) and RMI score (91.4%). Most of them presented in advanced stage III and IV (85.7%) with histology type high grade serous 2 carcinoma (82.8%). Eleven patients (31.4%) underwent primary cytoreductive surgery and 24 (68.5%) patients received neoadjuvant chemotherapy with three to six cycles of Carboplatin and Paclitaxel and underwent interval cytoreductive surgery. At surgery, majority had no residual disease (R 0 94.2%).

Conclusions: Majority of epithelial ovarian carcinoma occurred in postmenopausal women with abdominal distension. Most of them presented in advanced stage III-IV with histology high grade serous carcinoma. They underwent interval cytoreductive surgery more than primary cytoreductive surgery. At surgery, majority had no residual disease.
Predictors of Preventable Tooth Loss due to Extraction- A Cross-Sectional Study
Authors: Kumar Mahat Arun , Bahadur Basnet Lila , Puri Reecha , Kumar Shrewastwa Mukesh , Panta Niranjan
Published: November 2021

Introduction: Dental extraction is an irreversible treatment and knowledge about patient’s perspective to submit an extraction request is essential to help develop guidelines that support oral surgeons in describing the ethical and legal issues, guiding them in decision-making, and responding to extraction requests. This study was planned to investigate the potential correlations between the predictors and extraction of permanent tooth that could be saved, in our area of practice.

Methods: The patients were divided into two categories; Group 1: teeth can be saved and Group 2: teeth cannot be saved. Habits of the patients, their socio-demographic variables, medical history, reasons for a dental visit, reason for teeth extraction, and anatomical location of teeth were analyzed as a risk factor for preventable teeth loss using student t-test or chi-square test where appropriate.

Results: Preventable tooth loss occurred more commonly at the age of 41 to 50 years of life. Low educational level and anatomic location of the tooth (anterior/posterior positioning) were more significantly associated with the loss of tooth that can be saved at the time of the visit. Extraction of the mandibular right first molar tooth was significantly more on patient request compared to other teeth. Social disbelief was a major factor in opting for patients to choose extraction over teeth preservation.

Conclusions: Additional care and counseling are required whenever risk factors such as: age group (41 to 50 years), low educational level, attrition and abrasion, endodontic failures, and treatment of first molars are present.
RESEARCH OF THE SETTLEMENT OF PRAGUE-KORCHAK CULTURE IN RIVNE CITY
Authors: Voitiuk O. P. , Pryshchepa B. A.
Published: November 2021

The paper introduces into scientific circulation the results of research of the objects of Early Slavs of the Prague-Korchak culture in a multi-layered settlement in the southern part of Rivne city. The settlement is located on the eastern shore of the Basiv Kut Reservoir, on the oval hill measuring 220 Ч 120 m. The first finds of the Early Middle Ages were discovered here by V. K. Piasetskyi in 1989. In 2019, the excavations were carried out on the area of 590 m2; the housing and storage pit of the Prague-Korchak culture have been discovered. The quadrangular foundation pit of 3.5 Ч 3.5 m square was sunk into the earth to the 0.3—0.4 m from detection level. The remains of stone stove made on the wooden frame were located in the northern corner of the dwelling. Such semi-dugout dwellings with the stove in one of corners was the main type of residential buildings in the population of the Prague-Korchak culture. The pillar holes found in the corners of the foundation pit and in the middle of the walls indicate the frame-pillar construction of the wooden walls. Among the stones from the destroyed stove and on the earthen floor in the central part of the foundation pit of the dwelling the remains of nine clay pots were found. We managed to reconstruct the full profiles of seven of them; two else vessels are represented by the profiles of the upper parts. The pots from the dwelling have a conical body, weakly marked shoulder, scarcely marked neck and short rim. The surface of the item is insufficiently smoothed and bumpy. The admixtures in the clay are mostly of small and medium size, with added fireclay, grus and sand. By their size the vessels are divided into small (1), medium (5) and large (3). All pots from the dwelling belong to variants 1—3 of the first type according to I. P. Rusanova’s classification. This combination is typical of the early monuments of the Prague-Korchak culture. The analysis allows attributing the ceramic complex from Rivne to phaze 1 according to I. O. Havritukhin and to date it as belonging to the second half of 5th — mid-6th centuries. The settlement was not large; two or three farmsteads could simultaneously exist there. They were located at a distance of 100—150 m from each other.
FARMSTEADS OF THE SALTIV CULTURAL HISTORICAL COMMUNITY ON MOKHNACH П SETTLEMENT: SELECTION CRITERIA AND HOUSEHOLD STRUCTURE
Authors: Koloda V. V.
Published: November 2021

Farmstead planning of Mokhnach П settlement during the time of existence of the Saltiv cultural historical community within the second half of the 8th — mid-9th centuries is analyzed in the paper. The settlement was included into the residential agglomeration (microregion) with the center in Mokhnach hillfort. Some categories of household living buildings and ways of their location in relation to this or other dwelling are distinguished within the bounds of the largest excavation site 1. Generally, 36 Saltiv sites were identified on the mentioned area; among them there are 4 dwellings, 4 slightly deepened household buildings, 3 summer kitchens, 4 constructions for harvest storage (1 vault, 2 cellars and 1 box room) and 21 household pits (two of them were used to prepare clay for ceramics production). The planography analysis of the present complexes of the excavation site 1 allows to admit that in the south eastern part of the settlement there were 4 farmsteads that belonged to separate families which did their own housekeeping. The usable area was not large (12—18 m2). It points to the fact that a so-called «small family» consisting of 4—6 persons owned a certain household. Borderlines of these farmsteads do not overlap one another — it shows that they coexisted together at the same time. There is enough space for passage of people or transport vehicles between the farmsteads. Structure of household buildings is generally similar. The dwelling was accompanied by a slightly deepened household building, a summer kitchen, a construction for harvest storage, and a certain amount of household pits.

At the same time, some differences are also can be observed. In two cases (farmstead 2, 4), a small household pit located very close to a household building has been discovered. In the farmsted 3 no summer kitchen was identified, and in the farmstead 1 no construction for harvest storage was found as well. In three other cases (farmsteads 2—4), buildings for harvest storage differed between one another by a form, construction and storage capacity. In the each farmstead the amount of household pits that could coexist at the same time did not exceed 5 units.

Thus, it can be noticed that the square of the identified farmsteads, the characteristics of the household buildings, amount of supportive household pits and their location point to the quite convenient organization of the living space and the opportunity to do housekeeping successfully.
COINS FROM EXCAVATIONS AT THE «T-4» SECTOR IN OLBIA
Authors: Kozlenko R. O. , Sheiko I. M. , Reuter A.
Published: November 2021

Coins from the excavations of the «T-4» site in 2018—2020, located in the Terrace City of Olbia, are introduced into scientific circulation. The total number of coins found during three years of research is 154 items, half of which are dolphin-shaped coins. These include a treasure of coins and bronze items, which, in particular, contained 26 casted dolphin-shaped coins. The coin in the shape of a «wheel» from the West Pontic city of Istria also belongs to the Classical period. Coins of the Hellenistic era from the excavations at the «T-4» sector are represented by denominations with images of Apollo, Demeter and the eagle on a dolphin, Tyche in a crown in the shape of a tower and an archer, and borysthenes coins. Among the numismatic monuments of this time is a rare coin of the city of byzantium of the IV c. BC, which confirms the evidence of the Olbian inscription (НО 9) on trade contacts between these cities during the Hellenistic period.

The latest coins of the pre-Getae Olbia are represented by coins of the Asia Minor city of Amis, which are dated by the end of the II — the first half of the I c. BC. These are tetrachalkos with images of the Ares head in a helmet and a sword in sheath, and Aegis with the head of Medusa and Nike. Their appearance in Olbia is associated with the inclusion of the city in the Pontic state of Mithradates VI Eupator, in particular the localization of the Pontic garrison in Olbia.

Coins of Roman times are represented by Olbian assarius such as Zeus / eagle of the middle of the I c. AD, dupondius of the second half of the II c, AD and a tressis depicting the Roman Empress Julia Mamaeia, which belongs to the last series of monetary units of the Olbian autonomous minting. In general, the available numismatic material from the excavations of the T-4 site is dated from the second half of the VI c. BC, and until the cessation of coinage in the second third of the III c. AD, i. e. covers all major chronological periods of existence of Olbian polis.
SUPERCOMPUTER MOLECULAR MODELING FOR RESEARCH ON COMPLEX CATALYC REACTIONS AND PHARMOCOLOGICAL PROBLEMS OF CHOLINESTEASES
Authors: Masson P. , Makhaeva G.F. , Petrov K.A. , Grigorenko B.L. , Nemukhin A.V. , Varfolomeev S.D.
Published: November 2021

In the present talk, works on supercomputer molecular modeling of interaction mechanisms of cholinesterases with substrates and inhibitors, related to biomedical problems are described.
DIGITAL MODELING OF IN VITRO RESEARCH
Authors: Ermolaeva A.V. , Vladimirov G.K. , Gordleeva S.Yu. , Zaikin A.A. , Timashev P.S.
Published: November 2021

In this work, an integrated mathematical model of the liver cell, cholesterol metabolism, and drug interactions was developed. The model reproduced the well-known biology of cholesterol regulation, which confirms its potential for minimizing cellular research in the initial testing of new drugs for cardiology.
MOLECULAR PROFILE OF A HEALTHY PERSON – MODERN RESEARCH TRENDS
Authors: Tarbeeva S.E. , Lisitsa A.V. , Ponomarenko E.A.
Published: November 2021

Information about the trends in studies of molecular profiles of healthy people has been obtained.
MOLECULAR MARKERS FOR CANCER DIAGNOSIS AND THERAPY
Authors: Skripova V.S. , Bulatova L.F. , Savenkova D.S. , Nurgalieva A.K. , Vlasenkova R.A. , Reshetnikova D.D. , Timonina A.A , Bogdanov M.V.
Published: November 2021

Using CRISPR/Cas9 and SEREX technologies we have identified and characterized more than two hundred potential molecular markers of oncological diseases. It was shown that the sodium-dependent phosphate transporter NaPi2b is a unique target for the development of antitumor targeted drugs due to its localization and tumor-specific epitope.
APPROACHES TO INCREASING THE EFFICIENCY OF THE ELECTROCATALYSIS OF CYTOCHROME P450 3A4
Authors: Shumyantseva V.V.
Published: November 2021

An electrochemical system based on cytochrome P450 and riboflavin has been developed, which makes it possible to increase the yield of the product in a model system using cytochrome P450 substrate - erythromycin. Achieved an increase in the catalytic activity of cytochrome P450 by 28-36%.
BIOTECHNOLOGICAL PRODUCTION OF LANTIBIOTICS USING LICHENICIDIN-MODIFYING ENZYMES FROM BACILLUS LICHENIFORMIS
Authors: Ovchinnikova T.V. , Balandin S.V.
Published: November 2021

In this work we investigated the possibility of using the lantibiotic lichenicidin- modifying enzymes for the biotechnological production of other antimicrobial peptides of the lantibiotic class.
WAYS TO IMPROVE THE TRADITIONAL COCARBOXYLASE SORPTION PURIFICATION TECHNOLOGY
Authors: Kotova N.V. , Kovaneva A.V. , Kholodaeva S.V. , Pyatiizbyantsev T.A.
Published: November 2021

This work presents the results of experiments of cocarboxylase sorption from a model solution on sorbents of various structures under static and dynamic conditions. The sorbent was selected for the development of a sorption-chromatographic method for the isolation of cocarboxylase from a mixture of thiamine esters.
RECONSTRUCTION OF FUNCTIONAL EQUIVALENTS OF THE SKIN USING CELL AND TISSUE TECHNOLOGIES
Authors: Rogovaya O.S. , Chermnykh E.S. , Osidak E.O. , Kiseleva E.V. , Rippa A.L. , Ryabinin A.A. , Beilin A.K. , Gurskaya N.G. , Vorotelyak E.A.
Published: November 2021

The work is based on obtaining a living skin equivalent based on a three-dimensional scaffold consisting of type I collagen and other components of the extracellular matrix. The composition of the equivalent includes dermal and epidermal cells, it significantly accelerates and normalizes the healing process of chronic wounds. The living equivalent of the skin is a start for the further development of tissue-engineered constructs-analogs of skin and equivalents of other human tissues: at present, in particular, work is underway to study the stromal fractions of the dermis to control epithelial-mesenchymal interactions in vitro.
MAGNETIC SELECTION OF TRANSDUCED CELLS USING NOVEL SURFACE MARKERS
Authors: Kandarakov O.F , Bruter A.V. , Petrovskaya A.V. , Belyavsky A.V.
Published: November 2021

The possibility of using HA- and FLAG–tags embedded into CD52 surface protein for magnetic separation of transduced cells in vitro was investigated. The efficiency of selection of transfected cell lines, both with single and binary tags, was shown to exceed 85%. Thus, surface markers on the basis of CD52 protein with integrated HA- and FLAG-tags are applicable for cell selection by the MACS method.
QUANTUM CHEMICAL ARTIFICIAL NEURAL NETWORK QSAR-MODELLING FOR ANTIGLYCATION ACTIVITY PREDICTION
Authors: Vasilev P.M. , Ibragimova U.M. , Rzaeva A.Sh.
Published: November 2021

As a result of work to create the optimal quantum-chemical neural network model for antiglycation activity prediction, a set of different neural network models was received.
TCR-PRED – WEB SERVICE FOR PREDICTING THE SPECIFICITY OF EPITOPES FOR TCR CDR3 SEQUENCES BASED ON THEIR STRUCTURAL FORMULAS
Authors: Rudik A.V. , Filimonov D.A. , Lagunin A.A.
Published: November 2021

A new web-service predicting probability of T-cell receptor binding with major histocompatibility complex has been created based on the PASS software. Web-service is available on the link: http://way2drug.com/TCR-pred/ index.php
METHODS FOR REDUCING THE DETECTION LIMIT OF IMMUNOCHROMATOGRAPHIC TEST SYSTEMS FOR ANTIBIOTIC CONTROL IN HONEY
Authors: Barshevskaya L. , Sotnikov D. , Zherdev A. , Dzantiev B.
Published: November 2021

Methods for increasing the sensitivity of immunochromatographic test systems for the determination of low molecular weight analytes are proposed. The developed analysis schemes were tested in the determination of sulfonylamide and chloramphenicol in honey.
ANNEALING OF OLIGONUCLEOTIDE HAIRPINS AS EFFECTIVE APPROACH TO IMPROVE THE ANALYTICAL CHARACTERISTICS OF AMPLIFICATION METHOD FOR MICRORNA DETERMINATION BASED ON CATALYTIC HAIRPIN ASSEMBLY REACTION
Authors: Sakharov I.Y.
Published: November 2021

This work presents a new approach for reducing the background reaction of the catalytic hairpin assembly (CHA) amplification method, based on optimizing the conditions for annealing of hairpin oligonucleotide probes. This approach made it possible to improve the analytical characteristics of the amplified CHA-based method for microRNAs quantitation.
ANALYTICAL SOLUTION FOR SAFE BREASTFEEDING. IMMUNOCHROMATOGRAPHIC ASSAY OF MACROLIDE ANTIBIOTICS IN MOTHER'S MILK
Authors: Galvidis I.A. , Raysyan A. , Schneider R.J. , Eremin S.A.
Published: November 2021

When antibiotics are given to nursing women, clarithromycin (CLA), roxithromycin (ROK), erythromycin (ERI), azithromycin (AZI), dirithromycin (DIR), and oleandomycin (OLE) are excreted in breast milk. A rapid group-specific antibody test for these analytes in breast milk has been developed as a self-monitoring tool for safe feeding in infants.
DEOXYURIDINE TRIPHOSPHATES MODIFIED WITH AROMATIC TYROSINE GROUPS FOR ELECTROCHEMICAL DETERMINATION OF RECOMBINASE POLYMERASE AMPLIFICATION PRODUCTS OF DNA
Authors: Kutdusova G. , Suprun E.
Published: November 2021

Deoxyuridine triphosphates modified with tyrosine or tryptophan aromatic groups were tested as electroactive ‘labels’ for the electrochemical detection of double-stranded DNA amplicons obtained by recombinase polymerase amplification.
HYBRIDIZATION ANALYSIS ON COLORIMETRIC BIOCHIPS FOR QUANTITATIVE DETERMINATION OF BETA-LACTAMASE GENES IN ANTIBIOTIC RESISTANT BACTERIA
Authors: Rubtsova М.Yu. , Fursova N.K. , Presnova G.V. , Ulyashova M.M. , Grigorenko V.G. , Egorov А.М.
Published: November 2021

A method of hybridization analysis on colorimetric biochips for the quantitative determination of nucleic acids has been developed. The assay conditions and the method of processing digital images of biochips using different color models have been optimized. The method was applied for the quantitative determination of DNA and mRNA of serine beta-lactamases in Gram-negative bacteria resistant to beta-lactam antibiotics.
OCCURRENCE AND MOLECULAR GENETIC CHARACTERISTICS OF GRAPEVINE PINOT GRIS VIRUS IN RUSSIA
Authors: Shvets D. , Vinogradova S.
Published: November 2021

For the first time in Russia Grapevine Pinot gris virus (GPGV) was detected on the vineyards of the Stavropol Territory and the Republic of Crimea. It has been discovered by real-time PCR that the distribution of GPGV in the vineyards of the Krasnodar Territory is 82%, in the Stavropol Territory - 94% and in the Republic of Crimea - 68%. Nucleotide percentage similarity of the Russian GPGV isolates in comparison with the closest isolates from Genbank was 97,5-99,5%.
ELECTROANALYSIS IN POSTGENOMIC ERA: RESULTS AND PERSPECTIVES
Authors: Bulko T.V. , Kuzikov A.V. , Masamrech R.A. , Agafonova L.E. , Gilep A.A. , Usanov S.A.
Published: November 2021

A method for electroanalysis of the catalytic activity of polymorphic modifications of cytochrome P450 2C9, 2C9 * 2 and 2C9 * 3 has been developed. A study of the mechanisms of interaction of DNA with drugs was carried out.
BIOCATALYTIC PROCESSES OF LOW-TEMPERATURE SYNTHESIS OF ESTERS. MODULATION OF THE FUNCTIONAL PROPERTIES OF LIPASE BY THE CHOICE OF SOLVENT AND SUPPORT FOR IMMOBILIZATION
Authors: Perminova L.V. , Pykhtina M.B. , Beklemishev A.B.
Published: November 2021

Biocatalytic processes for the synthesis of valuable products, such as different esters for various purposes, have been studied using heterogeneous biocatalysts prepared by immobilizing the recombinant lipase rPichia/lip on mesoporous silica (SiO2) and macroporous carbon aerogel (MCA). It was found that the functional properties of immobilized lipase, such as enzymatic activity, specificity toward pair of substrates (acid and alcohol), the molecules of which differ in the number of carbon atoms (C), as well as operational stability, depended on the method of adsorptive immobilization, the chemical nature of the support, and polarity of the organic solvent, i.e. logP. The functional properties of rPichia/lip have been shown to be modulated by the selection of an organic solvent and support for lipase immobilization.
BIOHYBRID MATERIALS AS PROMISING BIOCATALYSTS IN THE DEVELOPMENT OF BIOFILTERS FOR THE METHANOL WASTEWATER TREATMENT
Authors: Ponamoreva O.
Published: November 2021

Yeast cells were immobilized in a matrix made of tetraethoxysilane (TEOS) and methyltriethoxysilane (MTES) by one-step sol-gel route of synthesis in the presence of polyethylene glycol (PEG) or polyvinyl alcohol (PVA). . A trickling biofilter with and without active aeration was designed using entrapped yeast cells to treat methanol polluted wastewater.
PREPARATION OF COATINGS BASED ON PH- AND THERMOSENSITIVE POLYMERIC MICROGELS FOR ENGINEERING OF GLUCOSE OXIDASE BIOSENSOR SYSTEMS
Authors: Shalybkova A. , Sharifullin T. , Pergushov D. , Sigolaeva L.
Published: November 2021

Polymer-enzyme coatings based on pH-and thermosensitive microgel P(NIPAM-co-DMAPMA) and glucose oxidase were fabricated via two different ways: (a) a sequential deposition (adsorption) of polymer and bio- components and (b) a deposition of a pre-formed microgel-enzyme complex. It was shown that the way (a) allows obtaining sensor surfaces with higher responses while the method (b) leads to ones with better operational stability.
DEGRADATION OF PERSISTENT POLLUTANTS BY LIGNINOLYTIC FUNGI
Authors: Dubrovskaya E. , Balandina S. , Golubev S. , Kryuchkova Ye. , Grinev V. , Sigida E. , Turkovskaya O.
Published: November 2021

Screening of 20 strains of basidio- and ascomycetes for their degradative activity toward PAHs, nonionic surfactants, alkyl phenols, synthetic dyes, and oil permitted us to select the most active fungi which hold promise for further studies and for use in biotechnology.
POLYMERIC COMPOSITE MATERIAL FOR BONE IMPLANTS WITH THE FEASIBILITY OF INTRAOPERATIVE FORM CORRECTION
Authors: Senatov F.S. , Strukova N.V. , Krivozubov M.S. , Generalova M.S. , Nikitin K.E. , Orlova P.A. , Grunina T.M. , Poponova M.S. , Lunin V.G. , Karyagina A.S.
Published: November 2021

A biomimetic composite material based on polylactide (PLA), polycaprolactone (PCL) and hydroxyapatite (HAP) with high biocompatibility and osteoconductive properties was developed. The structural and mechanical characteristics of the material were investigated and in vitro and in vivo studies were carried out.
THE POSSIBILITY OF USING ION-TRACK MATRICES BASED ON POLYESTERS TO CREATE ARTIFICIAL CONNECTIVE TISSUE
Authors: Petrova D.V. , Koshlan I.V. , Nechaev A.N.
Published: November 2021

Currently, one of the rapidly developing applications of polymer matrices, or scaffolds, is tissue engineering. The usage of ion-track technologies to create scaffolds for the cultivation of various cell populations can open up new opportunities in fundamental cell biology and practical regenerative medicine.
NEW METHOD FOR NANOMECHANICAL AND MORPHOLOGICAL TISSUE MAPPING ON LIVE BRAIN SLICES
FOR DIFFERENTIAL DIAGNOSTICS OF GLIOMA
Authors: Shmelev M.E. , Shved N.A. , Kumeiko V.V.
Published: November 2021

Method for nanomechanical and morphological mapping of the brain using atomic force microscopy (AFM) on live slices has been developed. The conditions and parameters for obtaining live brain slices that meet the requirements of AFM using a composite hydrogel have been selected, and the necessary characteristics of the probes have been established. On the live brain slices, maps of nanomechanical and morphological characteristics of normal tissues and glioblastoma were obtained.
SCALING OF THE PROCESS OF OBTAINING RECOMBINANT GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR AND OBTAINING CONSTRUCTS BASED ON IT
Authors: Esina T.I. , Gogina Ya.S. , Kaplina O.N.
Published: November 2021

In this work, scaling of the process of obtaining recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) have been demonstrated and GM-CSF molecular constructs with adjuvant activity have been obtained. The scaling-up made it possible to obtain up to 5 mg of the target protein with a purity of more than 96% from 1 g of wet cells.
BIOCONJUGATE OF R-PHYCOERYTHRIN WITH AG0 NANOPARTICLE – FUNCTIONAL NANOSTRUCTURE FOR CANCER THERANOSTICS, FLUORESCENT BIOSENSORS AND ELECTROCHEMICAL BIOINTERFACES
Authors: Kurganov B.I.
Published: November 2021

Bioconjugate Ag‧PE was obtained by the synthesis of silver nanoparticles in the phycoerythrin tunnel cavity without an exogenous reducing agent. Physicochemical properties of the conjugate and analysis of published data indicate that Ag‧PE can find application for diagnostics and therapy (theranostics) of cancer, as well as fluorescent biosensors and electrochemical biointerfaces.
REGULATION OF BIOCATALYTIC PROPERTIES OF RHODOSPIRILLUM RUBRUM L-ASPARAGINASE BY THE FORMATION OF ENZYME CONJUGATES WITH POLYCATIONS
Authors: Zhdanov D.D , Sokolov N.N. , Kudryashova E.V.
Published: November 2021

Covalent conjugates of asparaginase with copolymers of chitosan-PEG, chitosan-glycol and chitosan-PEI were obtained and their antitumor activity on human chronic myeloma leukemia K-562 cells was determined.
TRYPSINOLYSIS OF POLYURETHANE PARTICLES BASED ON СYCLODEXTRIN WITH ENCAPSULATED MOXIFLOXACIN
Authors: Yakupova L.R. , Skuredina A.A. , Kudryashova E.V.
Published: November 2021

This work proposes a conceptually new approach to the development of drug formulations with prolonged action – polyurethane particles based on cyclodextrin with encapsulated moxifloxacin, as well as the study of the kinetics of drug molecule release in the presence of trypsin.
MAGNETIC NANOPARTICLES COATED BY SERUM ALBUMIN AS A DELIVERY SYSTEM FOR IMMUNO-, CHEMO- AND PHOTODYNAMIC THERAPY DRUGS
Authors: Skorikov A.S. , Ivanova A.V. , Ostroverkhov P.V. , Gabashvili A.N. , Fedotov K.A. , Melnikov P.A. , Abakumov M.A. , Chekhonin V.P.
Published: November 2021

A series of nanoformulations of various antitumor compounds loaded onto serum albumin modified magnetic maghemite nanoparticles was obtained. The significant potential of these nanoparticles in the framework of various malignant neoplasms therapy approaches was demonstrated.
A note on variational formalism for sloshing with rotational flows in a rigid tank with an unprescribed motion
Authors: Lukovsky I. A. , Timokha A. N.
Published: November 2021

UDC 517.9
The Bateman – Luke-type variational formulation of the free-boundary ‘sloshing’ problem is generalized to irrotational flows and unprescribed tank motions, i.e., to the case where both the tank and liquid motions should be found simultaneously for a given set of external forces applied to fixed points of the rigid tank body. We prove that the variational equation, which corresponds to the formulated problem, implies both the dynamic (force and moment) equations of the rigid body and the free-boundary problem, which describes sloshing in terms of the Clebsch potentials.
Іван Олександрович Луковський (до 85-річчя від дня народження)
Authors: Editorial board .
Published: November 2021

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Сингулярний інтегральний оператор у просторах, які визначаються за допомогою узагальненої осциляції
Authors: Rzaev R. M. , Aliyeva L. R. , Huseinova L. E.
Published: November 2021

УДК 517.518.13
Вивчено поведiнку багатовимiрного сингулярного iнтегрального оператора у функцiональних просторах, якi визначаються за допомогою умов на узагальнену осциляцiю функцiї.
Signless Laplacian determination of a family of double starlike trees
Authors: Sharafdini R. , Abdian A. Z. , Behmaram A.
Published: November 2021

UDC 517.9Two graphs are said to be -cospectral if they have the same signless Laplacian spectrum.A graph is said to be DQS if there are no other nonisomorphic graphs -cospectral with it. A tree is called double starlike if it has exactly two vertices of degree greater than 2.Let with denote the double starlike tree obtained by attaching pendant vertices to one pendant vertex of the path and pendant vertices to the other pendant vertex of In this paper, we prove that is  DQS for
Estimates for analytic functions concerned with Hankel determinant
Authors: Örnek B. N.
Published: November 2021

UDC 517.5
We give an upper bound of Hankel determinant of the first order for the classes of an analytic function. In addition, an evaluation with the Hankel determinant from below will be given for the second angular derivative of analytic function. For new inequalities, the results of Jack's lemma and Hankel determinant were used. Moreover, in a class of analytic functions on the unit disc, assuming the existence of an angular limit on the boundary point, the estimations below of the modulus of angular derivative have been obtained.