bluuebunny/crossref_metadata_2025 huggingface dataset:
Sustainable Development Goals: Multicollinearity Between Therapeutic Entrepreneurship and Rehabilitation Therapy among African Nations
Authors: Orugba Harry Ovharhe
Published: January 2023

This study explored the multicollinearity between therapeutic entrepreneurship and rehabilitation therapy among African nations with the moderating role of sustainable development goals. The study adopted correlational design, exploratory design and cross-sectional cohort study. The study used non-proportionate stratified random sampling techniques and purposive sampling techniques. A total population of 55 rehabilitation professionals and sample size of 48 was determined using Krejcie and Morgan Table formula at 0.05 level of significance. Also, 48 copies of questionnaire were distributed to the respondents, while 42 copies were completed, retrieved, processed and analyzed. The instrument was validated with rehabilitation experts practising entrepreneurship, also various approach were employed to authenticate the reliability, the outcome of Cronbach Alpha Co-efficient is 0.954 (95.40%), Spearman-Brown equal length is 0.974 (97.40%) and Guttman Split-Half Coefficient is 96.10 (0.961). Ten research questions and ten hypotheses were raised which was tested with multiple regression analysis and KMO/Barllet’s test for the sampling adequacy on data appropriateness and sphericity respectively via SPSS 25 version. From the findings, therapeutic entrepreneurship aligned positively with occupational therapy, physical therapy and speech therapy. In conclusion, the apriori expectations could be deduced that there is positive outcome from the Condition Index and Eigenvalue which revealed there is minute multicollinearity presence among the therapeutic innovation skills, therapeutic risk culture and therapeutic passion in alignment with rehabilitation therapy, but was ignored because of the VIF and Tolerance outcome. Hence, it could be generally concluded that the study alignment is based on correlational rather than collinearity. This is in accord with the findings from the regression model used to analyze the hypotheses. Thus, the null hypotheses were rejected, while the alternate hypotheses were accepted. Based on the findings and conclusion, this study contributes to the knowledge that therapeutic entrepreneurship is an active support to SDG and booster to entrepreneurs with capability to rehabilitates business enterprise owners with unawesome condition, challenges and cases (i.e. trauma, autism, amputation and deformity) in line with their entrepreneurial journey, dreams and vision. It could be recommended that entrepreneurship rehabilitation therapist should be employed as a major trend of research and development towards achieving the SDG and should be design as academic curriculum. Additionally, it should be adopted as course of study in vocational and technical training program.
Realismo contemporáneo y modernidad en el cine de la frontera norte de México
Authors: Sánchez Baltazar Alba Nidia
Published: January 2023

Partiendo de la revisión de las estrategias del realismo y del cine moderno, y analizando la película La Paloma y el Lobo (2019) dirigida por Carlos Lenin, este ensayo busca indagar en el papel desempeñado por el cine de la frontera norte de México en la comprensión tanto de las condiciones contextuales actuales de la región, como del devenir histórico al que se ha sometido la franja fronteriza a partir de la instauración del neoliberalismo en el país.
Dibujar la complejidad. El diagrama en la investigación artística dentro de la academia
Authors: Horcajada González Ricardo
Published: January 2023

Desde principios del siglo XXI el giro epistemológico en las investigaciones académicas hacia lo visual ha obligado a los investigadores de todas las áreas a proveerse de herramientas y estrategias que faciliten la transferencia visual de grandes cantidades de información. Uno de los sistemas más eficaces es el diagrama. Nuestra propuesta es la de concebir el diagrama, de manera sumaria, en toda su magnitud y posibilidad. Tanto como sistema de síntesis en la transferencia como de espacio especulativo donde interaccionan procesos cognitivos complejos. Este proceso de modelización cognitiva mediante el dibujo genera un marco especulativo construido mediante habilidades y conocimientos propios de nuestra área. En este artículo hacemos un resumen de los principales modos y aspectos del diagrama como proceso gráfico de modelización cognitiva.
Hernia abdominal interna, reporte de un caso.
Authors: Banchón Rivas Pedro , Rodríguez Rivadeneira Walter , Eras Condoy Edipson
Published: January 2023

Introducción: Las hernias abdominales internas son protrusiones cuyo origen se puede atribuir a un defecto congénito o adquirido. La presentación clínica de este tipo de hernias representa un desafío para el profesional médico que trata de diagnosticarlo, la sintomatología puede ser intermitente o constante en otros casos, elevando de esta manera el riesgo de estrangulaciones y por ende de obstrucciones intestinales. Materiales y métodos: Se presenta el caso clínico de una paciente de 41 años de edad acude por emergencia con cuadro clínico de 12 horas de evolución caracterizado por dolor abdominal a nivel de mesogástrio, acompañado de distensión abdominal y masa a nivel de región umbilical, con cambio de coloración de la piel. Se realizó intervención quirúrgica de hernia estrangulada, posterior al procedimiento realizado, se aprecia paciente con palidez generalizada, taquipnea y taquicardia. Se realizó una segunda intervención donde se pudo identificar tejido intestinal invaginado dentro de anillo formado en el propio tejido, de características necróticas con una extensión de 20 cm aproximadamente a nivel de íleon proximal. Discusión: La patología herniaria intraabdominal es una de las causas más raras de presentación de un abdomen obstructivo, las cirugías abdominales previas o los traumatismos pasados pueden convertirse en un factor de riesgo, dentro de los exámenes complementarios la tomografía abdominal tiene un gran valor diagnóstico y el tratamiento de estas hernias radica primordialmente en resolver la obstrucción a través de cirugía. Conclusión: La sospecha de esta patología permite un curso de acción oportuno que reduce considerablemente la mortalidad de los pacientes.
Consumo de alcohol e ideación suicida en adolescentes y jóvenes: una revisión sistemática
Authors: Zamorano-Espero Jesús Antonio , Ahumada-Cortez Jesica Guadalupe , Valdez-Montero Carolina , Gámez-Medina Mario Enrique , Herrera-Paredes José Manuel
Published: January 2023

Objetivo: Analizar la información disponible sobre el consumo de alcohol e ideación suicida en adolescentes y jóvenes. Metodología: Se realizó una búsqueda sistematizada en las bases de datos EBSCO, SciELO, Elsevier, Biblioteca Virtual en Salud y Google académico. Se establecieron criterios de inclusión y exclusión, se desarrollaron estrategias de búsqueda, se llevó a cabo la selección de los artículos a incluir con la lista de chequeo de Joanna Briggs Institute, extracción de los datos y síntesis de los datos. Resultados: El 66.6% de los estudios presentan relación entre las variables de estudio. El 44.4% refieren que quienes presentan un consumo elevado de alcohol tienen mayor probabilidad de presentar ideación suicida, comparado con aquellos que reportaron un consumo de bajo riesgo. Conclusiones: La investigación de este fenómeno en la población objetivo aún se encuentra en desarrollo. Esta revisión posibilitó el reconocimiento de la influencia del tipo de consumo de alcohol (sensato, riesgo, perjudicial) para la ideación suicida. Los estudios indican que el consumo elevado de alcohol puede ser peligroso, pues aumenta la probabilidad de ideación suicida.
EVOLUTION AND ROLE OF THE DEWAXING PROCESS IN OIL REFINING
Authors:   Al-Farabi Kazakh National University, KLASSEN I.A. , ABDILDINA K.M. ,   Al-Farabi Kazakh National University;  SCIENTIFIC RESEARCH INSTITUTE FOR NEW CHEMICAL TECHNOLOGIES AND MATERIALS, 96а, Tole bi str., 050012, Almaty, Kazakhstan, ZAKIROV ZH.YE. ,   Al-Farabi Kazakh National University
Published: January 2023

Currently, the dewaxing process is used throughout the oil industry. There is a lot of research and interest in this process as necessary in the production of fuels for cold regions, as well as lubricating oils. For dewaxing, mesoporous high-silica zeolites with different structures have been used for a long time, offering sufficient activity in the process. Dewaxing can be divided into several types and is actively used not only in the oil industry, but also in biology and medicine. In this article, an overview of the dewaxing process development stages and the most popular research on this topic was made, various indicators and physicochemical parameters were considered.
INFLUENCE OF THE NATURE OF THE ALUMINUM SOURCE ON THE PHYSICO-CHEMICAL CHARACTERISTICS OF THE CARRIER OF CATALYTIC SYSTEMS FOR THE PETROCHEMICAL INDUSTRY
Authors:   SCIENTIFIC RESEARCH INSTITUTE FOR NEW CHEMICAL TECHNOLOGIES AND MATERIALS, 96а, Tole bi str., 050012, Almaty, Kazakhstan, G.K. VASSILINA  ,   Al-Farabi Kazakh National University, Almaty, Kazakhstan, A.K. ABDRASSILOVA  ,   SCIENTIFIC RESEARCH INSTITUTE FOR NEW CHEMICAL TECHNOLOGIES AND MATERIALS, 96а, Tole bi str., 050012, Almaty, Kazakhstan,   Al-Farabi Kazakh National University, Almaty, Kazakhstan
Published: January 2023

In the oil refining industry of the Republic of Kazakhstan, catalysts based on synthetic zeolites are mainly used. However, it was found that catalysts of this type have a number of disadvantages. For example, most of them have pore sizes in the micropore range, which is the reason for diffusion limitations. The solution to this problem can be found by creating catalysts based on mesoporous aluminosilicate. Mesostructured aluminosilicates are widely used as catalysts for petrochemical processes due to their high specific surface area, highly ordered pore structure and narrow pore size distribution and the possibility of regulating the size of their pores during synthesis. Mesoporous aluminosilicates are widely used as catalysts for petrochemical processes due to their high specific surface area, highly ordered pore structure and narrow pore size distribution and the possibility of regulating the size of their pores during synthesis. The article presents the synthesis of mesoporous aluminosilicates by copolycondensation of tetraethylortosilicate with various sources of aluminum: secondary aluminum butoxide (MAS-1) and aluminum triisopropoxide (MAS-2). The presence of a mesoporous and ordered structure in the synthesized aluminosilicates was confirmed by the data of low-temperature nitrogen adsorption/ desorption, X-ray diffraction and FT-IR. Acidic data were investigated by the method of infrared spectroscopy of the Fourier transform with diffuse reflection (DRIFT). It is shown that the nature of the aluminum source affects both the specific surface area and porosity, and the acidic characteristics of the synthesized mesoporous aluminosilicates.
Perspectives on the Fate of Absorbed Nitrogen in Dairy Farms
Authors:   Ruminant Nutrition and Physiology Laboratory, College of Animal Science and Technology, Shandong Agricultural University, Taian 271018, China, Zhao K. , Luo B. ,   Institute for Energy, Environment and Sustainability Research, UR-NCEPU, North China Electric Power University, Beijing 102206, China, Wu Y. W. ,   School of Environmental Science and Engineering, Shandong University, Jinan 250100, China, Liu W. ,   Ruminant Nutrition and Physiology Laboratory, College of Animal Science and Technology, Shandong Agricultural University, Taian 271018, China
Published: January 2023

The demand for milk rises dramatically due to the increased global population without damaging the standard of living. As a result, the scale of the dairy industry in the world is growing rapidly. Consequently, a concomitant problem that needs to be faced is the environmental impact of the by-products produced during the operation of the dairy farm. Among the substances produced in dairy farms, the most harmful pollutant to the environment is nitrogen (N). In addition, the N pollution from dairy farms is significant and N has a great danger to human health and society. This study provides a systematic review on how to alleviate N pollution from dairy cows during milk production and the removal of ammonia and nitrate from dairy wastewater via biochar adsorption. First, from a physiological perspective, the metabolic pathways of amino acids and ammonia in the rumen, portal-drained viscera, liver, and mammary gland of dairy cows are elaborated, as well as the measures to improve N utilization. In the second part, the progress of research on the removal of ammonia and nitrate by biochar adsorption and the involved mechanisms are summarized. Modified biochar has a significant improvement in nitrate removal due to weakening the repulsive effect of ions. Based on the review of this paper, it can provide relevant theoretical support for future studies on N pollution mitigation from dairy farms.
HİPOKSİK İSKEMİK ENSEFALOPATİDE UMBLİKAL KORD PH VE İZLEMDE ALINAN KARDİYAK BELİRTEÇLERİN YENİDOĞAN VE BEBEKLİK DÖNEMİ NÖROGELİŞİMSEL SONUÇLARA ETKİSİ
Authors: TANDIRCIOĞLU Ümit Ayşe , METE YEŞİL Ayşe , ÇELİK Tolga , ÖZMERT Elif N. , YİĞİT Şule
Published: January 2023

AMAÇ: Hipoksik iskemik ensefalopati (HİE); anormal bilinç durumu, nöbetler, çoklu organ yetmezliği ile seyredebilen klinik bir durumdur. Bu retrospektif çalışma ile terapötik hipotermi (TH) uygulanan HİE tanılı yenidoğanların kord kan gazı pH değeri ve kardiyak belirteçleri ile difüzyon Manyetik rezonans görüntüleme (MRG), nörolojik muayeneleri ve gelişimsel sonuçlarının değerlendirilmesi amaçlanmıştır.

GEREÇ- YÖNTEM: Ocak 2015- Ocak 2021 tarihleri arasında Hacettepe Üniversitesi İhsan Doğramacı Çocuk Hastanesi Yenidoğan Yoğun Bakım Ünitesi'ne yatırılarak HİE evre 2-3 tanısı ile TH tedavisi almış ve poliklinik izlemine gelen hastalar çalışmaya dahil edildi. Umblikal kord kan gazı pH, Troponin-I, CK-MB değerleri, diffüzyon MRG bulguları ile Bayley Bebekler ve Küçük Çocuklar için Gelişimi Değerlendirme Ölçeği-III (BSID-III) sonuçları karşılaştırıldı.

BULGULAR: Çalışmaya alınan 17 hastanın ortalama gebelik haftası 39 hafta (37-41), doğum ağırlıkları ortalama 3360 ± 325 g, 13’ü (%59) erkekti. Hastaların aEEG/EEG izleminde 10 (%59)’unda nöbet tespit edilmedi. Kordon kan gazı pH değeri ortancası ile anormal difüzyon MRG sonuçları arasında istatistiksel olarak fark saptanmadı. BSID-III skorları ile kord kan gazı pH değerinin ortancası arasında; kalp belirteçleri ile difüzyon MRG ve BSID-III sonuçları arasında istatistiksel fark saptanmadı.

SONUÇ: Hipoksik iskemik ensefalopati olan bebeklerde TH endikasyonu için kullanılan kord kan gazı değerleri uzun dönem nörolojik-gelişimsel prognozun öngörülmesinde yeterli değildir. Hasta sayısı arttırıldığı takdirde bu hastalarda kalp kasının hipoksiden etkilendiğini gösteren kardiyak enzimleri uzun dönem izlemde bebeğin karşılaşabileceği nörolojik-gelişimsel sorunları öngörmede yararlı olabileceğini söyleyebiliriz.
Adição de cinzas de casca de ovo e concha marinhas para melhorar as propriedades físicas e mecânicas do concreto
Authors: Cueva Abigail Kenia Hurtado , Auccatoma Mayli Pariona , Condori Luis Jimmy Clemente , Flores Leopoldo Choque
Published: January 2023

Nossa pesquisa visa modificar as propriedades físicas e mecânicas do concreto pela adição de cinzas de casca de ovo e concha marinhas. Esta investigação ocorre em decorrência da implantação de novas adições de materiais alternativos onde há a necessidade de se investigar a adição de cinzas de casca de ovo e concha marinhas e como isso pode influenciar nas propriedades físicas e mecânicas do concreto. A investigação teve um delineamento experimental, onde foram realizados 36 tubos de ensaio de resistência à compressão e 36 tubos de ensaio de tração e 24 ensaios físicos, onde foram adicionados CCH e CCA nas proporções de 2% CCH e 1% CCA; 4% CCH e 1,5% CCA e 6% CCH e 2,5% CCA que foram avaliados aos 7, 14 e 28 dias.Portanto, concluiu-se que a adição de CCH e CCA em (4% e 1,5%) e (6% e 2,5%) modificam as propriedades negativamente, enquanto as porcentagens de menor adição de cinzas (2% e 1%) modificam positivamente melhorando propriedades físicas e mecânicas do concreto.
Detection of X-Ray Bursts in Astronomical Time Series: The Burst of GRO J1744-28 as an Example
Authors: Zhao Hongyang , Jin Jing , Liu Yi , Shen Yi , Jiang Yu
Published: January 2023

To automatically, accurately, and quickly detect local changes in time-series data continuously emitted by X-ray sources, an autoencoder-based unsupervised learning anomaly detection method is proposed. Here, we consider the X-ray burst of GRO J1744-28 as our case study. First, we tested the proposed method using simulation data and a test set based on a phenomenologically motivated light-curve fitting of different burst types. Our method exhibited superior performance, achieving F-scores of 0.969 and 0.936 for the detection of small bursts with low peak count rates such as structured bursts and microbursts, respectively. Then, based on Rossi X-ray Timing Detector observation data for GRO J1744-28 during the outburst period, we identified low-amplitude bursts using the proposed method and analyzed the burst regularity of GRO J1744-28. Our approach does not require complex modeling and has powerful feature extraction and detection capabilities, which can be used to automatically and efficiently detect changes in a data stream.
A Light in the Dark: Searching for Electromagnetic Counterparts to Black Hole–Black Hole Mergers in LIGO/Virgo O3 with the Zwicky Transient Facility
Authors: Graham Matthew J. , McKernan Barry , Ford K. E. Saavik , Stern Daniel , Djorgovski S. G. , Coughlin Michael , Burdge Kevin B. , Bellm Eric C. , Helou George , Mahabal Ashish A. , Masci Frank J. , Purdum Josiah , Rosnet Philippe , Rusholme Ben
Published: January 2023

The accretion disks of active galactic nuclei (AGNs) are promising locations for the merger of compact objects detected by gravitational wave (GW) observatories. Embedded within a baryon-rich, high-density environment, mergers within AGNs are the only GW channel where an electromagnetic (EM) counterpart must occur (whether detectable or not). Considering AGNs with unusual flaring activity observed by the Zwicky Transient Facility (ZTF), we describe a search for candidate EM counterparts to binary black hole (BBH) mergers detected by LIGO/Virgo in O3. After removing probable false positives, we find nine candidate counterparts to BBH mergers during O3 (seven in O3a, two in O3b) with a p-value of 0.0019. Based on ZTF sky coverage, AGN geometry, and merger geometry, we expect ≈3(N
BBH/83)(f
AGN/0.5) potentially detectable EM counterparts from O3, where N
BBH is the total number of observed BBH mergers and f
AGN is the fraction originating in AGNs. Further modeling of breakout and flaring phenomena in AGN disks is required to reduce our false-positive rate. Two of the events are also associated with mergers with total masses >100 M
⊙, which is the expected rate for O3 if hierarchical (large-mass) mergers occur in the AGN channel. Candidate EM counterparts in future GW observing runs can be better constrained by coverage of the Southern sky as well as spectral monitoring of unusual AGN flaring events in LIGO/Virgo alert volumes. A future set of reliable AGN EM counterparts to BBH mergers will yield an independent means of measuring cosmic expansion (H
0) as a function of redshift.
Constraints on the Hosts of UHECR Accelerators
Authors: Muzio Marco Stein , Farrar Glennys R.
Published: January 2023

Interactions of ultra-high-energy cosmic rays (UHECRs) in the surroundings of their accelerators can naturally explain the observed spectrum and composition of UHECRs, including the abundance of protons below the ankle. Here we show that astrophysical properties of the UHECR source environment such as the temperature, size, and magnetic field can be constrained by UHECR and neutrino data. Applying this to candidate sources with a simple structure shows that starburst galaxies are consistent with these constraints, but galaxy clusters are in tension with them. For multicomponent systems like active galactic nuclei and gamma-ray bursts, the results are indicative, but a customized analysis is needed for definitive conclusions.
Physical Activity Habits Among Older Adults Living With Rheumatic Disease
Authors: Kumthekar Anand , Pedro Sofia , Michaud Kaleb , Ozen Gulsen , Katz Patricia , Baker Joshua , Ogdie Alexis
Published: January 2023

Objective

To describe levels of physical activity (PA) in older adults with rheumatic and musculoskeletal diseases (RMDs) and study the association between PA level and patient-reported outcomes.

Methods

Using data from FORWARD, a cross-sectional analysis was performed among adults aged 65 years and older with RMDs to assess the levels of PA. PA was categorized as high (vigorously active for at least 30 minutes, 3 times per week), moderate (moderately active for at least 3 times per week) or low (seldom active). We assessed the self-reported levels of PA among patients with different types of RMDs and assessed the association between levels of PA and PROs, including the 29-item Patient Reported Outcomes Measurement Information System (PROMIS-29) assessment.

Results

Among the 3343 eligible participants, rheumatoid arthritis (68%) was the most common RMD. High PA was reported by 457 (13.6%) participants, and 1820 (54.4%) reported moderate activity. Overall, participants reported a median of 7 (IQR 0-15) days of moderate to vigorous level of PA for ≥ 30 min per month. Obese participants were significantly more likely to report low levels of activity (44% of obese compared to 25% of nonobese individuals). Participants with low PA levels had higher (worse) pain scores, higher (worse) Health Assessment Questionnaire–Disability Index scores, higher depression rates, and worse PROMIS-29 scores related to pain, sleep and fatigue.

Conclusion

Among patients with RMDs, levels of high PA were relatively low among older patients. These observations, though descriptive, support a relationship between physical inactivity and obesity, depression, poor sleep, and fatigue in patients with RMDs.
Prevalence and Associated Factors of Facet Joint Ankylosis in Patients With Axial Spondyloarthritis
Authors: Lee Bong-Woo , Jung Joon-Yong , Kim Moon-Young , Hong Yeon Sik , Park Sung-Hwan , Kang Kwi Young
Published: January 2023

Objective

To investigate the prevalence of facet joint ankylosis in the whole spine in axial spondyloarthritis (axSpA) using low-dose computed tomography (LDCT), and to identify factors associated with facet joint ankylosis.

Methods

Whole spine LDCT images from 161 patients with axSpA were examined, and the presence of facet joint ankylosis was assessed (right and left, C2–S1) by 2 readers. Facet joint ankylosis was scored from 0 to 46. Structural damage of vertebral body was assessed using CT Syndesmophyte Score (CTSS). Factors associated with ankylosed facet joint scores for the whole spine were identified using a generalized linear model with a negative binomial distribution.

Results

Seventy-nine patients (49%) and 70 patients (43%; reader 1 and reader 2, respectively) had ≥ 1 ankylosed facet joint. Facet joint ankylosis was most common in the thoracic spine. The mean score of facet joint ankylosis for the whole spine was 6.6 (SD 11.2) in reader 1 and 4.2 (SD 8.4) in reader 2. Whole spine facet joint ankylosis score positively correlated with Ankylosing Spondylitis Disease Activity Score (ASDAS) and CTSS. In multivariable analysis, the ankylosed facet joint score was associated with ASDAS, sacroiliitis, CTSS, and a history of uveitis in both readers. Uveitis history, ASDAS, and CTSS were associated with whole spine facet joint ankylosis score in subgroup analysis of only radiographic axSpA.

Conclusion

The prevalence of ankylosed facet joints is high in axSpA, especially in the thoracic segment. The whole spine ankylosed facet joint score is significantly associated with a history of uveitis, ASDAS, sacroiliitis, and syndesmophyte score.
Validation of the Antineutrophil Cytoplasmic Antibody Renal Risk Score and Modification of the Score in a Chinese Cohort With a Majority of Myeloperoxidase-Positive Patients
Authors: Ni Anqi , Chen Liangliang , Lan Lan , Wang Yaomin , Ren Pingping , Zhu Yilin , Xu Ying , Shen Xiaoqi , Zhou Qin , Huang Xiaohan , Wang Huiping , Chen Jianghua , Han Fei
Published: January 2023

Objective

We aimed to validate and modify the renal risk score for antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) in a Chinese cohort with a majority of myeloperoxidase (MPO)-positive patients.

Methods

A total of 285 patients with biopsy-proven AAGN in our center were retrospectively included. Patients were randomly assigned to the development set (n = 201) and the validation set (n = 84). We calculated the renal risk score and analyzed the clinicopathological characteristics and follow-up data. The nomogram was constructed based on the independent prognostic factors identified by the multivariable Cox regression and then compared with the renal risk score.

Results

Over a median follow-up period of 41.3 (range 20.0-63.8) months, 84 (29.5%) patients reached end-stage kidney disease (ESKD). In the development set, hypertension (hazard ratio [HR] 2.16, 95% CI 1.08-4.32,P= 0.03), high serum creatinine (HR 1.002, 95% CI 1.001-1.003,P< 0.001), high daily urine protein (HR 1.34, 95% CI 1.15-1.57,P< 0.001), high glomerular sclerosis (HR 13.98, 95% CI 3.50-55.92,P< 0.001), and interstitial fibrosis > 50% (HR 4.18, 95% CI 1.90-9.19,P< 0.001) were independent risk factors for ESKD, and these indicators were included in the nomogram. The C-indices of the nomogram model in the development set, validation set, and all-data set were 0.838 (range 0.785-0.891), 0.794 (range 0.774-0.814), and 0.822 (range 0.775-0.869), respectively, which were higher than those of the renal risk score model, 0.801 (range 0.748-0.854), 0.746 (range 0.654-0.838) and 0.783 (range 0.736-0.830), respectively. The net reclassification improvement and the integrated discrimination improvement further illustrated the higher predictive ability of the nomogram.

Conclusion

We present a nomogram as a practical tool to predict renal outcomes in Chinese patients with MPO-ANCA glomerulonephritis.
In vitro and in silico evaluation of antiretrovirals against SARS-CoV-2: A drug repurposing approach
Authors: Zapata-Cardona Maria I. , Florez-Alvarez Lizdany , Guerra-Sandoval Ariadna L. , Chvatal-Medina Mateo , Guerra-Almonacid Carlos M. , Hincapie-Garcia Jaime , Hernandez Juan C. , Rugeles Maria T. , Zapata-Builes Wildeman
Published: January 2023

Background

Drug repurposing is a valuable strategy for rapidly developing drugs for treating COVID-19. This study aimed to evaluate the antiviral effect of six antiretrovirals against SARS-CoV-2 in vitro and in silico.

Methods

The cytotoxicity of lamivudine, emtricitabine, tenofovir, abacavir, efavirenz and raltegravir on Vero E6 was evaluated by MTT assay. The antiviral activity of each of these compounds was evaluated via a pre-post treatment strategy. The reduction in the viral titer was assessed by plaque assay. In addition, the affinities of the antiretroviral interaction with viral targets RdRp (RNA-dependent RNA polymerase), ExoN-NSP10 (exoribonuclease and its cofactor, the non-structural protein 10) complex and 3CLpro (3-chymotrypsin-like cysteine protease) were evaluated by molecular docking.

Results

Lamivudine exhibited antiviral activity against SARS-CoV-2 at 200 µM (58.3%) and 100 µM (66.7%), while emtricitabine showed anti-SARS-CoV-2 activity at 100 µM (59.6%), 50 µM (43.4%) and 25 µM (33.3%). Raltegravir inhibited SARS-CoV-2 at 25, 12.5 and 6.3 µM (43.3%, 39.9% and 38.2%, respectively). The interaction between the antiretrovirals and SARS-CoV-2 RdRp, ExoN-NSP10 and 3CLpro yielded favorable binding energies (from −4.9 kcal/mol to −7.7 kcal/mol) using bioinformatics methods.

Conclusion

Lamivudine, emtricitabine and raltegravir showed in vitro antiviral effects against the D614G strain of SARS-CoV-2. Raltegravir was the compound with the greatest in vitro antiviral potential at low concentrations, and it showed the highest binding affinities with crucial SARS-CoV-2 proteins during the viral replication cycle. However, further studies on the therapeutic utility of raltegravir in patients with COVID-19 are required.
Design, Implementation, and Evaluation of Online Bioinformatics and Neuroinformatics Labs
Authors: Doukakis Spyridon , Vrahatis Aristidis , Exarchos Themis , Hadjinicolaou Μaria , Vlamos Panagiotis , Mouza Chrystalla
Published: January 2023

In recent years, online laboratories have become highly integrated into the educational process due to the development of distance learning tools as well as the pandemic. As part of a master's degree program in bioinformatics and neuroinformatics, in the academic years 2020-2021 and 2021-2022, the mandatory module "Laboratory Education (LE)" included 9 labs and a special session took place online. For the evaluation of the LE a survey was carried out among the participants on issues of satisfaction with each lab, the knowledge they acquired, the educational material given to them, with the facilitator per lab as well as their self-reported learning. 73 postgraduate students participated in the survey. According to the results, the overall satisfaction from each laboratory ranged from 3.94 to 4.49/5.00. Furthermore, there is a variety of values in self-reported learning ranging from 23 to 50/50. Finally, although 7 out of 10 students say they are satisfied with the distance structure of LE, 8 out of 10 say they prefer LE to be carried out with a physical presence in the labs.
Former les enseignant·es à l’évaluation de la cohérence/cohésion textuelle dans des textes narratifs.
Authors: Garcia-Debanc Claudine
Published: January 2023

De nombreux travaux ont établi les difficultés des enseignant·es à formuler des annotations précises sur la cohérence et la cohésion textuelle des écrits d’élèves (Charolles, 1978 ; Halté, 1984 ; Rondelli, 2010 ; Elalouf, 2016). Cette contribution rend compte d’ateliers en formation continue visant à aider les enseignant·es à identifier et à traiter ces problèmes. Les activités s’appuient sur le corpus Resolco constitué de textes d’élèves et d’étudiants, du CE2 à la troisième, rédigés en réponse à une consigne imposant de résoudre des problèmes de cohésion textuelle. Les tâches successives proposées aux enseignant·es sont présentées et quelques-uns de leurs travaux sont analysés. Selon qu’ils doivent corriger les textes d’élèves comme ils le font à l’ordinaire, les évaluer en posant des questions à un informateur ou les réécrire, ils ne portent pas le même regard sur les textes d’élèves.
L’encadrement collégial : complexité et enjeux pour la professionnalisation de l’accompagnement doctoral
Authors: Girard Nathalie
Published: January 2023

Dans un contexte de professionnalisation de la formation doctorale, l’encadrement doctoral renvoie à un décloisonnement du binôme doctorant - directeur de thèse. Mais si l’encadrement collégial est devenu une norme à l’international, et une pratique courante en France, la littérature reste centrée sur les relations duales entre doctorant et directeur de thèse. L’objectif de cet article est de décrire la diversité des configurations organisationnelles des équipes d’encadrement doctoral. A partir d’un dispositif de formation à INRAE, nous avons constitué une base de données sur 76 thèses, avec les caractéristiques structurelles de la thèse et de son encadrement, mais aussi les difficultés exprimées par les doctorants et encadrants. L’analyse de ces données nous permet de dégager quatre types d’équipes d’encadrement doctoral, au-delà des rares binômes entre un doctorant et son directeur de thèse. Les formes organisationnelles ainsi identifiées, parfois classiques (binômes d’encadrants HdR / non HdR), d’autres plus complexes constituant des équipes pluridisciplinaires et/ou pluri-institutions autour du doctorant, voire élargies à des acteurs du monde socio-économique, sont décrites et confrontées aux difficultés rencontrées par les protagonistes de ces thèses. L’analyse transversale de ces résultats nous permet de dégager à la fois des pistes en termes de formation des doctorants et encadrants, des points de vigilance pour les institutions qui financent et hébergent ces thèses, mais aussi des perspectives de recherche dans le champ de l’accompagnement doctoral.
Quand un projet de recherche international se fait accompagnateur d’un parcours doctoral : retours d’expériences des actrices
Authors: Adam Catherine , Plaud Cécile
Published: January 2023

Le parcours doctoral représente un processus de formation et de transformation des individus et l’accompagnement doctoral est un vecteur de professionnalité émergente. En s’appuyant sur un dispositif singulier, le dispositif RIIME (Recherche sur les Ingénieurs et la formation à l’Innovation au Maghreb face aux enjeux Environnementaux), notre recherche questionne le processus d’apprentissage des doctorantes qui y sont engagées. RIIME présente des spécificités fortes du fait de sa pluridisciplinarité et de sa dimension internationale. Des entretiens semi-directifs ont été conduits auprès des doctorantes. Deux dimensions du processus de professionnalisation structurent nos résultats. La première se situe au niveau individuel et dessine des apports en termes de confiance en soi, de prise de recul et de reconnaissance. La seconde relève du collectif et porte sur l’identification, l’intégration et l’internationalisation. Cette étude souligne les bénéfices et limites perçues de l’insertion de jeunes chercheurs dans un projet de recherche international lorsqu’il se fait dispositif d’accompagnement doctoral.
L’accompagnement par les pairs au doctorat pour socialiser les femmes au métier de chercheuse
Authors: Déri Catherine E. , Vincent Cynthia , Tremblay-Wragg Émilie
Published: January 2023

Malgré les progrès réalisés en matière de parité des genres, en milieu universitaire, les femmes demeurent désavantagées sur plusieurs plans. En tant que professeures, chercheuses ou étudiantes, elles ne bénéficient pas des mêmes possibilités que leurs confrères. Dans cet article, nous présentons les résultats d’une étude de cas mettant en exergue l’accompagnement par les pairs entre doctorantes devant s’approprier des compétences rédactionnelles pour s’insérer dans leur champ de recherche. En nous appuyant sur le cadre théorique de socialisation au métier de chercheur développé par Skakni (2011), nous analysons des extraits d’entrevues semi-dirigées menées auprès de 25 doctorantes provenant d’universités canadiennes. Les résultats révèlent une préférence des participantes de s’associer à leurs semblables dans des groupes de rédaction académique afin de normaliser les défis auxquels elles font face en milieu universitaire. De plus, elles semblent accorder autant de valeur à l’accompagnement dont elles bénéficient de leurs pairs que du soutien qu’elles offrent à leurs consœurs. En définitive, il en ressort des collaborations, autant professionnelles que personnelles, par l’établissement d’un réseau de chercheuses novices qui privilégient la solidarité, plutôt que la compétitivité habituellement observée aux cycles supérieurs. La discussion porte sur la perspective féminine de cette culture de compétitivité et des différences de genre menant à une disparité dans les besoins de socialisation qui règnent en milieu universitaire. Enfin, des suggestions sont offertes pour l’exploration d’actions sociales étudiantes, en complémentarité à l’encadrement institutionnel, afin d’optimiser la socialisation des doctorantes, et par le fait même, leur professionnalisation au monde de la recherche.
Quelles conceptions de la réflexivité dans l’écriture de recherche? Savoir de quel je on parle
Authors: Boch Françoise
Published: January 2023

L’article se présente sous la forme d’une note de synthèse consacrée au positionnement énonciatif du sujet dans l’écriture de recherche en sciences humaines, appréhendée ici sous l’angle de la réflexivité. L’objectif général est de rendre compte d’un ensemble de travaux disponibles sur cette notion large et polysémique dans différentes disciplines. L’article explore ainsi plusieurs manières d’envisager la réflexivité dans l’écriture de recherche et étudie en quoi ces différentes conceptions théoriques peuvent nourrir la réflexion relative au positionnement énonciatif des doctorants dans leur thèse, à travers différents je symbolisant ce positionnement.
Le MT180® ou les infortunes de l’excellence
Authors: Frances Jean , Le Lay Stéphane
Published: January 2023

Il y a dix ans maintenant, Ma thèse en 180 secondes® faisait son entrée dans les mondes francophones de la recherche et de l’enseignement supérieur. Inspiré d’un dispositif Australien, Three Minutes Thesis (3MT), cette compétition de communications pour doctorants porte les candidats à s’affronter les uns aux autres à coups de speechs de trois minutes censés rendre compte de leurs travaux de recherche. Il pourrait, en somme, s’agir d’une sorte de concours de vulgarisation visant à mettre en lumière « la relève de la recherche ». Or, à étudier précisément ce qui se dit et se joue au MT180® (Corsi et al.), il est permis d’en douter. Et, à demander à d’anciens lauréats ce qu’ils pensent de leur passage sur les planches du concours, l’analyse selon laquelle Ma thèse en 180 secondes® servirait premièrement à faire sortir les sciences des laboratoires et à valoriser les chercheurs en devenir demande à être réexaminée de près. Ce que nous proposons de faire ici.
Principled Integration of Technology for Science Learning That Lasts
Authors: Krahenbuhl Kevin S. , Rost Jim
Published: January 2023

The world of education is caught up in trends that affect all corners of contemporary society. Those who are working in the sciences have to help students learn in this new environment of fast-paced expectations and information overload. The intention of this chapter is to present a set of principles—or axioms—about learning that have direct bearing on instructional utilization of technology in the classroom. This will, in turn, provide a guide to an effective integration of technology that promotes learning that lasts within the sciences. The principles introduced herein balance knowledge of cognition as well as application in K12 science classrooms. The principles range from moderation to when to appropriately utilize technology for enhancing science learning to precision and extension in which emphasis is placed upon in what manner to focus technology integration to enhance science learning and also a principle of timely application that clarifies not just ‘when' in terms of content but also in terms of what skills and knowledge are in place among the students.
The effect of intraorifice barriers (TheraCal LC, Lime-Lite and Ionoseal) on the fracture resistance and failure patterns of endodontically treated teeth submitted to intracoronal bleaching
Authors: Feiz Atiyeh , Shams Masoomeh , Faghihian Hessamoddin , Yousefi Parwaneh
Published: January 2023

Background:

The aim of the study was to compare the root reinforcement potential of different light cured intraorifice barriers (TheraCal, lime-lite, Ionoseal and resin-modified glass-ionomer [RMGI] [Fuji II LC]) with or without bonding agent placed in the orifice of endodontically treated and bleached teeth.

Materials and Methods:

In this experimental in vitro study, single-rooted bovine teeth were instrumented and obturated with gutta-percha. Except the control group, in other specimens, gutta-percha was removed 3 mm under cementoenamel junction. Then, the specimens were divided into seven groups according to the bases was applied: TheraCal LC, TheraCal LC with bonding agent, Lime-Lite, Lime-Lite with bonding agent, Ionoseal, Ionoseal with bonding agent, and RMGI (Fuji II LC). After internal bleaching, the teeth were decoronated. Then, all the groups were subjected to fracture resistance testing using Universal Testing Machine. For evaluating fracture resistance, analysis of variance and Tukey's test were used and for comparing the mode of fracture fisher test was applied in SPSS software. The significance was determined at (α = 0.05) confidence interval.

Results:

The group of TheraCal LC with bonding agent showed better fracture resistance as compared to the control group (P = 0.004). Although there was no statistically significant difference in the pairwise comparison between the other groups.

Conclusion:

TheraCal LC with bonding agent can be used as intraorifice barriers with good fracture resistance in endodontically treated and bleached teeth.
Association between tooth loss and risk of occurrence of oral cancer – A systematic review and meta-analysis
Authors: Gonde Noopur , Rathod Surekha , Kolte Abhay , Lathiya Vrushali , Ughade Suresh
Published: January 2023

Background:

Periodontitis, the second most common reason for tooth loss in adults, is a chronic inflammatory condition that increases the prevalence of cancer by inhibiting apoptosis and promoting tumor cell growth. However, it is still debatable if tooth loss is an important risk factor in oral cancer (OC). The aim of this systematic review is to analyze the relationship between tooth loss and the probability of developing head-and-neck cancer and also to see if there is an association between tooth loss, periodontitis, and the risk of OC.

Materials and Methods:

Studies that depicted a link between tooth loss and OC (till 2017) were searched from online databases accompanied by a thorough manual search of relevant journals. Data were collected from eligible studies, and meta-analysis was carried out using the Meta-Analysis software. The effect of various inclusions was assessed by sensitivity and subgroup analysis. Publication bias was also evaluated.

Results:

The meta-analysis consisted of 15 publications. When the number of teeth lost was counted, there was significant variability (I2 = 98.7%, P = 0.0001). When more than 15 teeth were missing in a subgroup analysis, there was a 2.4 times greater risk of OC (odds ratio: 2.496, 95% confidence interval [CI] = 2.067–3.015, P = 0.001) with no heterogeneity (I2 = 0.00%, 95% CI for I2 = 0.00–68.98). Subgroup analysis revealed that there was no evidence of publication bias.

Conclusion:

It was concluded that tooth loss can increase the OC risk by nearly 2 folds. However, large-scale population-based studies are needed to substantiate the findings.
Microshear Bond Strength of Composite to Superficial Dentin by Use of Universal Adhesives with Different pH Values in Self-Etch and Etch & Rinse Modes
Authors: Hosseini Mahtab , Raji Zahra , Kazemian Mehrdad
Published: January 2023

Background:

This study aimed to assess the microshear bond strength (micro-SBS) of two universal adhesives with different pH values in etch-and-rinse (E and R) and self-etch (SE) modes to superficial dentin.

Materials and Methods:

This in vitro experimental study evaluated 75 extracted sound human third molars. Superficial dentin was exposed by trimming the enamel and removing 0.5–1 mm of tooth structure beyond the dentinoenamel junction. A 600-grit abrasive paper was used to create smear layer. The teeth were randomly divided into five groups (n = 15). All-Bond Universal and G-Premio Bond were applied in E and R and SE modes in four groups. Clearfil SE Bond was used in the control group. Z350XT composite cylinders (0.9 mm diameter and 1.5 mm height) were then bonded to the prepared surface. The teeth were incubated at 37°C and 100% humidity for 24 h. Micro-SBS was measured by a universal testing machine, and the mode of failure was determined under a stereomicroscope. Data were analyzed using ANOVA, Bonferroni test, and Fisher's exact test (alpha = 0.05).

Results:

The micro-SBS of Clearfil SE Bond was significantly lower than all other groups (P < 0.05). All-Bond Universal yielded the maximum micro-SBS in SE and minimum micro-SBS in E and R mode. All-Bond Universal showed significantly lower micro-SBS in E and R mode than SE mode (P < 0.05). No other significant differences were noted. The mode of failure was also significantly different among the groups (P < 0.05). Mixed failure had the highest frequency in G-Premio in E and R mode.

Conclusion:

Type of adhesive and application mode affected the micro-shear bond strength to superficial dentin.
Effects of incorporating zinc oxide and graphene oxide nanoparticles on abrasion, translucency, and microhardness of flowable composite resin: In vitro
Authors: Ziaei Maryam , Alaghehmand Homayoun , Bijani Ali , Tabari Mitra
Published: January 2023

Background:

Zinc oxide (ZnO) and graphene oxide (GO) nanoparticles (NPs) have antimicrobial properties. The present study was undertaken to evaluate the effects of incorporating these NPs and their chemical and physical blends on abrasion, translucency, and microhardness of flowable composite resin.

Materials and Methods:

In the present in vitro study, flowable composite resin samples (Grandio Flow, VOCO, Germany) were evaluated in 5 groups and the sample size was 10 for each group of each experiment (n = 10) as follows: Group 1, without NPs; Group 2, with ZnO NPs; Group 3, with GO NPs; Group 4, containing a physical mixture of GO and ZnO; and Group 5, containing a chemical mixture of GO and ZnO NPs. In all the groups, 1 wt% of the NPs were incorporate into flowable composite resin. Abrasion, translucency, and microhardness of the samples were evaluated. Data were analyzed with analysis of variance, followed by post
hoc Tukey's tests at the level of significance of P < 0.05.

Results:

In Groups 2, 4, and 5 (all the groups containing ZnO), a significant decrease in abrasion and microhardness of flowable composite resin was observed compared to the control group. Incorporation of NPs in all the groups resulted in a significant decrease in translucency compared to the control group.

Conclusion:

Incorporation of NPs into flowable composite resin resulted in a decrease in translucency. The microhardness was reduced in groups containing ZnO, but the abrasion was also reduced in these groups. The incorporation of GO did not significantly alter the abrasion and microhardness of the composite resin.