bluuebunny/crossref_metadata_2025 huggingface dataset:
Precision Monitoring of Antithrombotic Therapy in Cardiovascular Disease
Authors: Yuan Meng , Wen Haichu , Wang Yuan , Du Jie
Published: March 2024

Thrombosis, the process of blood clot formation in blood vessels, is an important protective mechanism for avoiding excessive blood spillage when an individual is exposed to trauma. The body has both a thrombosis inhibition and a thrombus removal system, which interact in a balanced manner. If these mechanisms become unbalanced, and too many clots form and block the lumen, thrombosis occurs. Thrombosis is currently the leading cause of death from disease in humans and is one of the most common events leading to many cardiovascular diseases. Antithrombotic drugs are an integral part of the pharmacological treatment regimens, and interventional strategies are currently recommended for thrombotic complications in patients with thrombosis. Despite major advances in these therapies, the high risk associated with thrombosis and bleeding remains, because of the complex interplay among patient comorbidities, drug combinations, multifaceted dose adjustments, and care settings. Detailed assessment of the effects of bleeding and thrombosis is necessary to establish optimal treatment plans for patients with thrombosis. This study retrospectively evaluated methods for assessing the risk of bleeding/ischemia in thrombosis and the individualized use of these methods.
TTK M. 579 EMREDİCİ HÜKÜMLER İLKESİ KARŞISINDA MÜDÜRLERİN GÖREV SÜRESİNE İLİŞKİN ŞİRKET SÖZLEŞMESİ HÜKÜMLERİ
Authors: ÖZDOĞAN DALOĞLU Tuğba
Published: March 2024

Emredici hükümler ilkesi, 6102 sayılı Türk Ticaret Kanunu (TTK) ile hukukumuza girmiştir. Bu ilke, tüm sermaye şirketleri açısından kabul edilmiştir (TTK m. 340, 565/2, 579). TTK m. 579’de şirket sözleşmesinin TTK’nın limited şirketlere ilişkin hükümlerinden ancak Kanun’da buna açıkça izin verilmişse sapabileceği, diğer kanunların öngörülmesine izin verdiği tamamlayıcı nitelikteki şirket sözleşmesi hükümlerinin o kanuna özgülenmiş olarak hüküm doğuracağı düzenlenmiştir. İlkeye yöneltilebilecek birçok eleştiri olmakla birlikte çalışmamızda, bu ilkenin şirket sözleşmesinde tamamlayıcı hükümler öngörülmesini engelleyip engellemediği ele alınmıştır. Bu nedenle “sapma” kavramının kapsamı ve TTK hükümlerini tamamlayıcı şirket sözleşmesi hükümlerinin öngörülebilmesi için kanunda buna “izin” verilmesi gerekip gerekmediği üzerinde durulmuştur. Son olarak TTK m. 579 hükmünün değerlendirilmesiyle vardığımız sonuç doğrultusunda limited şirketlerde müdürlerin görev süresine ilişkin şirket sözleşmesi hükümleri incelenmiştir.
Arsa Payı Karşılığı İnşaat Sözleşmesinde Nama İfanın Koşulları
Authors: KORKUSUZ Sümeyye Tuba
Published: March 2024

Arsa payı karşılığı inşaat sözleşmesi kapsamında yüklenicinin; yapıyı sözleşmeye aykırı veya ayıplı inşa etmesi ile yarım bırakarak ortadan kaybolması oldukça yaygın bir durumdur. Bu gibi durumlarda arsa sahipleri, 6098 sayılı Türk Borçlar Kanunu’nun (TBK) 113/1 ile 473/2 hükümlerinde düzenlenen “nama ifaya” başvurabilir. Bu hükümlerin yanı sıra taraflar, mahkeme izni olmaksızın aralarında anlaşarak doğrudan nama ifayı uygulayabilir.

Nama ifaya başvurulurken bulunması gereken bazı maddi koşullar, TBK m. 113/1 ile TBK m. 473/2 için ortaktır. Genel hüküm niteliğindeki TBK m. 113/1 izne tâbi tutulmuşken özel hüküm niteliğindeki TBK m. 473/2, yükleniciye uygun süre verilip ihtar çekilerek uygulanabilir. Ancak uygulamada arsa sahipleri, TBK m. 473/2’deki maddi koşullar sağlansa dahi izlenmesi gereken usûl bakımından ileride çıkabilecek uyuşmazlıklar sebebiyle TBK m. 113/1 hükmünü tercih etmektedir. Çalışmamızda, arsa payı karşılığı inşaat sözleşmesinde hangi koşullarda nama ifaya başvurulabileceği ve uyulması gereken usûl incelenmiştir.
STATE OF NEURODYNAMIC FUNCTIONS AND REGULATORY PROCESSES OF THE HEART ACCORDING TO INDICATORS OF HEART RATE VARIABILITY IN INDIVIDUALS WITH INSUFFICIENT AND INCREASED BODY WEIGHT
Authors:   National Pedagogical Dragomanov University, Kyiv, Ukraine, Dobrostan O.V. , Plyska O.I. ,   National Pedagogical Dragomanov University, Kyiv, Ukraine
Published: March 2024

One of the most common diseases in the whole world is obesity. Every year, 18-20 thousand new cases of obesity are recorded in Ukraine. Also, the number of obese students during their studies in institutions of higher education is rapidly increasing, for whom the first year of study is the most difficult and problematic. It is known that even under normal conditions, excessive body weight requires increased energy supply and persons with insufficient weight suffer from a lack of reserves. Therefore, the purpose of our work was to study the features of the state of neurodynamic functions and regulatory processes of the heart based on indicators of heart rate variability in female students with different body weights during the first year of study at a higher education institution. This will be important for the development of individual disease prevention measures for this category of students. The study examined full-time female students (17-18 years old) of the Faculty of Natural Geography Education and Ecology of National Pedagogical Dragomanov University, who were divided into groups according to body mass index: normal, overweight, and underweight. The study was conducted on days of high mental performance under standard conditions in six stages. An electrocardiogram was registered, rhythmograms and variation pulsometry indicators were calculated, and the functional state of the central nervous system was studied using computer methods. According to the Kruskal-Wallis and ANOVA tests, the following indicators were most sensitive to the influence of body weight: moda, moda amplitude, stress index, autonomic balance index, and heart rate. According to Spearman’s non-parametric correlation analysis, at each stage of the examination, correlations between variation characteristics of heart rate variability and indicators of the state of the central nervous system were revealed, and their nature was clarified. It was established that the nature of the correlations in the studied groups was different. Thus, it was established that the deviation of body weight from the norm affects the regulatory processes of the heart and neurodynamic functions during the first year of study. Overweight and underweight female students during the first year of study had a significantly higher intension of regulatory mechanisms compared to female students with a normal body weight, so they can be classified as a group at risk of developing psychosomatic diseases.
Evaluating the Efficacy of a Traditional Approach to Marketing in the South African Pharmaceutical Industry during the Covid19 Pandemic
Authors: Msosa Steven Kayambazinthu , Khuboni Thembisa Charity
Published: March 2024

Purpose: The purpose of this study was to evaluate the efficacy of a traditional approach to marketing in the South African Pharmaceutical industry during the Covid-19 pandemic.
Design/Method/Approach: The study adopted a qualitative and exploratory research design with an interpretivist epistemological paradigm. Interviews were conducted using the Zoom virtual platform to adhere to social distancing restrictions. The interviews were recorded, transcribed, and analysed using QDA Miner Lite software. The purposive sample consisted of eight participants employed within the pharmaceutical and medical device industry.
Findings: The study found that the Covid-19 pandemic prompted pharmaceutical and medical device companies to modify their traditional marketing strategies. The restricted access of pharmaceutical sales and marketing representatives to healthcare facilities led to a shift towards digital marketing.
Theoretical Implications: The study contributes to the development of knowledge regarding the effectiveness of traditional marketing strategies in the pharmaceutical industry during times of disruption. It highlights the need for pharmaceutical companies to adapt their strategies and incorporate digital platforms into their marketing efforts.
Practical Implications: Practitioners in the pharmaceutical and medical device industry can learn from the study's findings by recognizing the importance of diversifying marketing strategies and embracing digital platforms. Adapting quickly to disruptive events such as the Covid-19 pandemic is crucial to maintaining market effectiveness.
Originality/Value: This study offers new insights into the efficacy of traditional marketing strategies in the South African pharmaceutical industry during a global pandemic. It emphasizes the value of incorporating digital platforms and diversifying marketing approaches to enhance industry resilience.
Research Limitations/Future Research: The findings of this study are specific to the South African pharmaceutical industry during the Covid-19 pandemic. Future research could explore the effectiveness of traditional marketing strategies in different geographical contexts and examine the long-term impact of incorporating digital platforms into marketing strategies.
Paper Type: Empirical
JEL Classification: : I11, M31, L89
Knowledge Transfer as a Driver of Innovative Performance of SMEs in Lagos State
Authors: Olayemi Olufemi , Akinsanya Damilola
Published: March 2024

Purpose: The ability to disseminate knowledge in the presence of innovation and capability in businesses creates an advantage over other businesses. Most SMEs do not implement formal tools to protect and share needed knowledge, which makes knowledge transfer difficult.

Design/Method/Approach: Quantitative research was adopted. With over eleven (11) thousand registered SMEs in Lagos State and using Yamane’s formula, a total of 386 respondents formed the sample size for this study.

Findings: The study established a positive significance of social networking, mentorship and research and development for innovation performance. However, training revealed no impact on innovation performance which further established that most SMEs operators in Nigeria usually improve business skills through apprenticeship instead of an organized training to transfer knowledge.

Theoretical Implications: The absorptive capacity theory was adopted to explain the importance of enriching organizational learning by the acquisition of diverse knowledge from different sources to enhance capabilities. It also depicts the impact of technological innovation performance through general abilities of an individual.

Practical Implications: The study emphasized that the survival and competitiveness of any business entity in an evolving global environment is dependent on its implementation of continuous innovative improvements through knowledge transfer, but of all knowledge transfer methods, training is the least used method by business owners.

Originality/Value: This paper assesses the significance of knowledge transfer as a driver of innovation performance in Nigerian SMEs using such methods as training, mentorship, research and development and social networking employed by SMEs.

Research Limitations/Future Research: One major limitation to the study was the inability and unwillingness of SMEs owners and managers to fill in a questionnaire.

Paper Type: Empirical

JEL Classification: M10, M13
Neural correlates of model-based behavior in internet gaming disorder and alcohol use disorder
Authors: Kwon Mina , Choi Hangnyoung , Park Harhim , Ahn Woo-Young , Jung Young-Chul
Published: March 2024

Background

An imbalance between model-based and model-free decision-making systems is a common feature in addictive disorders. However, little is known about whether similar decision-making deficits appear in internet gaming disorder (IGD). This study compared neurocognitive features associated with model-based and model-free systems in IGD and alcohol use disorder (AUD).

Method

Participants diagnosed with IGD (n = 22) and AUD (n = 22), and healthy controls (n = 30) performed the two-stage task inside the functional magnetic resonance imaging (fMRI) scanner. We used computational modeling and hierarchical Bayesian analysis to provide a mechanistic account of their choice behavior. Then, we performed a model-based fMRI analysis and functional connectivity analysis to identify neural correlates of the decision-making processes in each group.

Results

The computational modeling results showed similar levels of model-based behavior in the IGD and AUD groups. However, we observed distinct neural correlates of the model-based reward prediction error (RPE) between the two groups. The IGD group exhibited insula-specific activation associated with model-based RPE, while the AUD group showed prefrontal activation, particularly in the orbitofrontal cortex and superior frontal gyrus. Furthermore, individuals with IGD demonstrated hyper-connectivity between the insula and brain regions in the salience network in the context of model-based RPE.

Discussion and Conclusions

The findings suggest potential differences in the neurobiological mechanisms underlying model-based behavior in IGD and AUD, albeit shared cognitive features observed in computational modeling analysis. As the first neuroimaging study to compare IGD and AUD in terms of the model-based system, this study provides novel insights into distinct decision-making processes in IGD.
Driving and mobile phone use: Work addiction predicts hazardous but not excessive mobile phone use in a longitudinal study of young adults
Authors: Kun Bernadette , Paksi Borbála , Eisinger Andrea , Kökönyei Gyöngyi , Demetrovics Zsolt
Published: March 2024

Background and objectives

Work addiction (WA), characterized by dimensions such as overcommitment, difficulties in detachment from work, and work-life imbalance, is presumed to be associated with increased smartphone usage, even during risky activities like driving. The study investigated the connection between WA and future problematic and hazardous smartphone use, considering personality factors: anxiety, rumination, and worry.

Methods

A three-wave longitudinal study (N = 1,866) was conducted from March to July 2019, June to September 2020, and June to November 2021, involving a representative sample of 18-34-year-old residents in Hungary's capital. The study employed Hungarian versions of the Bergen Work Addiction Scale, Problematic Mobile Phone Use Questionnaire, Ruminative Response Scale, Anxiety subscale of the Brief Symptom Inventory 18, and Penn-State Worry Questionnaire. Additionally, author-developed questions on mobile phone use while driving were included.

Results

At baseline, those at risk for WA showed more frequent mobile phone use while driving at both time points 2 and 3 compared to the non-risk group. Path analyses revealed rumination, anxiety at time 1, and worry at time 2 as significant mediators between baseline WA and mobile phone use while driving at time 3. However, when analyzing all three mediators together, only anxiety at time 1 and worry at time 2 remained significant.

Discussion and conclusion

This study demonstrates that WA predicts future mobile phone use while driving through mediation by anxiety and worry. Our findings add to the growing evidence highlighting the detrimental aspects of WA, emphasizing the need for improved prevention and treatment strategies.
Evaluating responsive gateways amid future uncertainty at the London Bridge station (UK)
Authors: Lai Bryant M L , Martani Claudio , Roman Orlando , Adey Bryan T
Published: March 2024

The high concentration of people in train stations during rush hour poses a significant risk to passenger comfort and safety. Recent technological advancements in real-time crowd counting and pedestrian microsimulations have made it feasible to create responsive gateways for managing passenger flow to prevent overcrowding situations. This paper proposes a simulation-based cost–benefit analysis, utilising the real options methodology commonly employed to assess flexible infrastructure, to estimate the costs and benefits associated with implementing responsive gateways at the London Bridge station, UK, while considering uncertainties in passenger flow and the interests of various stakeholders. Results from the demonstrative example indicate that responsive gateways offer a better service than static ones mainly due to the expected reduction in the risks related to safety, travel time and comfort, which compensates for a higher cost of installation and maintenance. Further research is envisioned to enhance the modelling of passenger flow uncertainties and expand the objective function to encompass additional externalities. The simulation-based cost–benefit analysis proposed in this paper can be extended to a broader range of intelligent transportation systems, considering uncertainties and their diverse impacts on society. Thus, this paper presents a tool that contributes to a more transparent and objective investment decision making process, particularly concerning the development of smart cities.
Usages sociaux de l’eau en Guadeloupe
Authors: BONBONNE Cathy , POGGI Marie-Paule
Published: March 2024

Face aux données statistiques de Santé Publique France mettant en évidence le caractère extrême du milieu aquatique source de noyades, notre article s’intéresse à un contexte géographique insulaire, « La Guadeloupe », dont le peuplement s’est fait par la mer dans des conditions douloureuses. Il s’agit de mettre en lumière l’héritage culturel lié à l’eau, « environnement hors normes » propres aux conditions extrêmophiles (Detay et Thomas, 2018), ainsi que les facteurs qui l’actualisent, le transforment, l’inhibent sans négliger les conditions de sa transmission dans des contextes variés (socioculturel et scolaire). A partir d’une approche croisant anthropologie (Carrier, 1992, p. 52, citant Kroeber et Kluckhohn, 1952) et sociologie dispositionnaliste et contextualiste (Lahire, 1998, 2012), nous nous intéressons aux interactions entre usages sociaux de l’eau et croyances épistémologiques des enseignants qui fondent leurs usages didactiques de l’eau. Les résultats, issus de récits de vie et d’une enquête par questionnaires, mettent en évidence un processus de dynamique évolutive et plurielle de construction des représentations liées à l’eau dans un contexte géographique, social et historique spécifique. La tension entre actualisation et construction de dispositions constitue une source d’adaptation au milieu qui interroge les pratiques didactiques réelles.
Enseigner/apprendre la culture du risque majeur à l'école
Authors: WALLIAN Nathalie , CHANG Ching-Wei , NICOLAY Xavier
Published: March 2024

Science des risques, la cindynique prend rarement en charge la dimension culturelle de l’éducation au risque à/par l'école. Un déplacement dans différents espaces culturels exposés aux risques majeurs autorise le didacticien à questionner les manières dont les humains mobilisent les facultés cognitives et sociales pour s’éduquer à la survie. La mise en contraste autorise une pensée critique en contre-point des idées reçues/colportées sur le rapport est/ouest. A partir de trois études de cas choisis en France, à Taïwan et au Japon, l'étude vise à questionner l'étalonnage des gabarits conceptuels scolaires qui conçoivent l'extrême comme un état anormal et comme une menace exigeant la mobilisation de savoirs explicites. L'enjeu est de rendre poreuses les approches éducatives respectives en contextes aux fins de 1) se dégager d'un éduco-centrisme réducteur et 2) apporter des connaissances sur les différentes façons humaines de penser le risque, 3) agir en questionnant le lien qui unit solidairement et 4) déployer une démarche auto-constructive. Le rapport à la normation ou à la sécurisation par l’institution École est récursivement questionné en contextes.
Chevaucher sur le fil du rasoir
Authors: WALLIAN Nathalie , JACQUART Eric
Published: March 2024

Statistiquement, l'équitation est classée « pratique physique la plus accidentogène » (Mutore et al., 2023), par la gravité tant des traumatismes que des séquelles encourues. Se pose la question des stratégies déployées par le cavalier pour perdurer et produire une performance en situation de concours d'obstacles. Les données croisées sur étude de cas (N = 2 cavaliers expérimentés ; 2 concours de CSO amateur 3 et 2) comportent : 1) l'analyse des discours croisés sur la pratique (cavaliers, moniteur, observateur, propriétaires, chef de piste) ; 2) l'étude des incidents remarquables (IR) survenus durant le concours, la reconnaissance de chaque parcours et 3) l'analyse vidéo de la pratique (auto/hétéroscopie ; par les cavaliers et un expert). Les résultats permettent d'identifier les points d'attention relatifs à a) la gestion du risque et des contraintes de l'épreuve et b) l'optimisation de la performance mais également de c) mesurer les écarts entre intentions de course et réalisation effective, incidents inclus. Des régularités dans les postures et les intentions sont identifiées qui permettent d'ouvrir des pistes pour la réduction des risques liés à la pratique pour l'optimisation de la performance.
Logiques des contradictions dans les pratiques humaines subaquatiques
Authors: ELOI Serge
Published: March 2024

Relevant de milieux quasi extrêmophiles, les pratiques sub-aquatiques (apnée et plongée) soumettent les organismes à des contraintes qui les obligent à se transformer pour perdurer en gérant des contradictions. L’option théorique du matérialisme dialectique renvoie à l’usage de la dialectique comme pensée logique des contradictions. Si en apnée, l’accumulation de gaz carbonique conduit à limiter le temps passé sous l’eau et invite à remonter à la surface, en plongée descendre profondément et longtemps nécessite d’éliminer l’azote qui a diffusé dans les tissus et exige un temps de remontée plus long. L'apnéiste est ainsi amené à sortir de l’eau alors qu’il souhaiterait y rester tandis que le plongeur doit y rester quand il voudrait en sortir. Les techniques et procédures nécessaires à cette intromission en milieu aqueux sont discutées à l’aune des deux points de vue.
Insécurité langagière et identitaire en milieu post-colonial
Authors: JEANNOT-FOURCAUD Béatrice , ALBERI-BOUDHAU Olivia , APATOUT Phanuelle
Published: March 2024

L’objet de cet article est d’explorer les représentations et attitudes langagières d’enfants du primaire en Guadeloupe, à travers le prisme de leurs pratiques langagières déclarées mais également des normes et des contradictions éventuelles qui s’en dégagent. La société guadeloupéenne, ancrée sur un territoire insulaire et issue d’un contexte colonial, est principalement marquée d’un point de vue sociolinguistique par un bilinguisme créole/français, qui relève par ailleurs d’une dynamique diglossique. Les deux langues peuvent de fait se retrouver au cœur de tensions susceptibles de se cristalliser dans l’imaginaire des jeunes enfants. Nous nous intéressons donc aux effets produits par cette situation en termes d’insécurité linguistique (aussi bien statutaire qu’identitaire). Les représentations des enfants révèlent le caractère extrêmophile que peut avoir ce contexte sur la façon dont se construit l’identité langagière des enfants.
ЖАНРОВО-ТЕМАТИЧЕСКАЯ СПЕЦИФИКА РОМАНА ШИО АРАГВИСПИРЕЛИ “РАЗБИТОЕ СЕРДЦЕ”
Authors: INAURİ Vakhtang
Published: March 2024

В нижеследующей статье рассматривается роман Шио Арагвиспирели «Разбитое сердце», его жанровая специфика, художественный синтез сказочных и литературных форм, соотношение любви и искусства, прозаические пассажи, эпизоды и художественное пространство, отображенные в сказочном аспекте.

Рассмотрен писательский стиль, художественно-психологический нарратив автора в романе, оригинальность прорисовки персонажей, зафиксирован их характер, настроение и образная интерпретация эмоций. Охарактеризованы созданные этим методом сказочные, реалистические и романтические образы, их визуальный и духовный мир.

Проанализированы художественная символика музыкального колокольчика, созданного Махаре Окромчедели и его художественная функция от развития сюжета романа до его финала, показаны идейные, сказочные и фантастические тенденции произведения.

Изучена структура романа, он композиционно своеобразен по вошедшим в него нескольким басням. Сказка «о гусином пастухе», басня, рассказанная пастухами в лесу и другие представляют собой самостоятельные новеллы. Семь глав романа связаны между собой одной основной идеей – любовью Етери и Махаре. Здесь в полной мере проявился высокий уровень художественного нарратива Шио Арагвиспирели, которого раньше мы знали как большого мастера словесного искусства малых форм.

Изображенное в произведении художественное пространство – это в общем страна с королем. Время соответственно феодальная эпоха. Но век и годы в романе не определены, писатель это не конкретизирует, поскольку для сказки это не обязательно.
Rabies Virus Bat-Clade Sequencing v2
Authors: Godinho Fernanda , Campos Aline , not provided rosana-huff , Ruivo Amanda , Bauermann Milena , Bermann Thales , Luz Wallau Gabriel , Michel Roehe Paulo , Salvato Richard
Published: March 2024

Join us in advancing global genomic surveillance of the rabies virus. We are actively engaged in pioneering a pan-clade whole genome amplicon sequencing protocol for the rabies virus. If you're interested in collaborating on this crucial endeavor and wish to obtain a primer aliquot from our established protocol or the one currently in development, please do not hesitate to contact us at richardssalvato@gmail.com. Background Rabies virus (RABV) causes fatal encephalitis in domestic animals and humans. This high-impact zoonotic virus is poorly studied from the genomic perspective so establishing genomic surveillance protocols for RABV is crucial to track their evolution and monitor spillover events and wildlife reservoirs. Despite the importance of RABV zoonotic cycle, there is limited complete genome sequence data of RABVs from some hosts as bats. We developed a novel rapidly deployable, cost-effective, and flexible amplicon-based sequencing approach usable with protocols widely established during the COVID-19 pandemic and suitable to different hosts based on a one-health context. We used PrimalScheme to generate a primers panel and then aligned them with a RABV sequences dataset from different species and manually degenerated the primers to cover a wider diversity of hosts. The set of 47 primers is compatible and ready to use with COVIDSeq sequencing protocol and Illumina DNA Prep, and allows to sequence up to 384 samples per run on the Illumina MiSeq system or to accommodate in libraries with other sample types. Additionally, we included primers for amplification of a fragment of the mitochondrial gene COI to host species identification. COI Initial Validation In the initial validation, we sequenced 160 complete RABV genomes from different species from five distinct families (Bovine, Equine, Caprine, Felines, Microchiroptera) with an average coverage of 98%, most of them recovering the whole genome (88/160). Conclusions Here, we introduced a cost-effective and easy-to-use sequencing protocol for RABV bat-clade in order to support genomic surveillance of a re-emerging zoonotic disease allowing targeting viral control programs and adequate public health policies. Acknowledgements We would like to thank Instituto de Pesquisas Veterinárias Desidério Finamor for sample processing and initial rabies virus diagnosis.
Analysis of Learning Innovation Based on Multiple Intelligences (MI) Used in Teaching of Islamic Education
Authors: Khoeriah Ibnaturrofi , Shohib Muhammad Wildan , Nubail Ahmad
Published: March 2024

The existence of a dichotomy for students in the classroom makes transferring knowledge from teachers to students an inequality that runs ineffectively due to the difference between intelligent and unintelligent students, especially in learning Islamic education. This study analyzes learning innovations based on multiple intelligences (MI) in Islamic education subjects. This study is qualitative in nature, uses a library research approach, and the data analysis used is a descriptive-qualitative analysis. The data sources employed are from previous relevant research on multiple intelligence (MI)-based learning, such as international and national journals. However, Howard Gardner, a psychologist from Harvard University, adopted the study. This study revealed awareness that every student born into this world has their own uniqueness, which has the right to be recognized and appreciated in their learning environment and in developing their potential. Multiple intelligence (MI)-based learning is a form of learning innovation that can be an option for Islamic education teachers in Indonesia. Implementing multiple intelligences (MI)-based learning is intended to accommodate students' diverse intelligences.
Formation of Early Childhood Religious Character Through Storytelling Television Media (Viber) in Islamic History Learning at Kindergarten in Semarang City
Authors: Fitri Asya Ainul , Istiyani Dwi , Nurussaniyyah Aqilah , Rachman Syadzsa Fathna , Fi BaitiAgustin Nur Lintang
Published: March 2024

Character or morality is a very important aspect of life. It should be developed from an early age because early childhood is a crucial period of rapid growth and development for children. Therefore, it is necessary to instill good character and morals, one of which is through stories and exemplary tales of righteous predecessors. The stories of the Prophets serve as the primary alternative in enhancing the character and morality of children through storytelling. Hence, it is essential to design an engaging and appropriate medium for this purpose. This research employs a Research Development (RD) methodology, which is a type of research and development. The author has designed Viber as an engaging storytelling medium for children. Viber is designed to enhance the formation of religious character in early childhood. According to validation by media experts, it achieved an excellent rating of 86.6 out of 20, while the validation by content experts yielded a score of 77.5 out of 20. The results of the pre-test obtained a score of 22.2, while the post-test score was 30.6. Both values show significant improvement with an average increase of 8.4. Therefore, it can be concluded that the Television Storytelling Medium (Viber) is effective in enhancing the formation of religious character in early childhood.
Validity and Reliability of Pre-Service Teacher Competency Level in Teaching Early Mathematics Instrument Using the Rasch Model
Authors: Nordin Norazly , Ghazali Munirah , Radzali Nur Faridatul Jamalia , Hashim Nor Hashimah , Chear Syed Lamsah Syed
Published: March 2024

The Pre-Service Competency Teacher Level in Teaching Early Mathematics Instrument has been developed to measure the competency level and readiness to teach early mathematics in Preschool. This study was conducted to produce empirical evidence on the validity and reliability of this instrument by using the Rasch model. Surveys were conducted in three private universities that offer Early Childhood Education Programmes. A total of 85 pre-service teachers were selected as a sample of the study through simple random sampling. The validity and reliability of the instrument were measured using Rasch's model through Winstep software version 3.68.2. The findings of the unidimensionality test showed 46.1%. The Rasch analysis shows the person reliability index is 0.8 with a separation index is 2.05. The item reliability index is 0.91 and the separation index is 3.18. The item fitness analysis found 29 items in the instruments are in the valid range and one item that falls out of the allowed range. The finding showed that this instrument has a high degree of validity and reliability and can be used to measure the competency level of pre-service teaching in teaching early mathematics.
The Use Of Interactive Videos For Learning To Recognize Colors In Children With Disabilities
Authors: Rajani Rini
Published: March 2024

This research aims to develop the potential of children with disabilities by utilizing technology. The research method in this study uses descriptive qualitative method by collecting data based on observation and interviews. The subject in this study is a first-grade elementary school child. The result of this research is an individualized learning program tailored to the needs of the child. The results of the development of individualized learning programs using interactive videos are expected to help children develop optimally. This research is expected to be a reference for parents, teachers, and special education teachers, to develop potential optimally in an educational environment.
Pengaruh Augmented reality Terhadap Hasil Belajar Siswa dalam Mata Pelajaran Konstruksi dan Utilitas Gedung di SMK
Authors: Mukhtar Eragilang , Sudjani Sudjani , Supriatna Nandan
Published: March 2024

Penelitian ini dilakukan sebagai respons terhadap kesulitan yang dihadapi mahasiswa dalam memahami gambar-gambar 2D. Tujuan utama dari penelitian ini adalah untuk menilai sejauh mana efektivitas penerapan Teknologi Augmented reality (AR) dalam proses pengajaran pemahaman gambar, serta dampaknya pada pencapaian hasil belajar mahasiswa pada mata pelajaran konstruksi bangunan dan utilitas di SMKN 1 Majalengka. Metode yang digunakan dalam penelitian ini adalah Metode Desain PraEksperimental, lebih tepatnya menggunakan DPIB. Partisipan penelitian terdiri dari 72 siswa yang terbagi dalam dua kelas, yakni kelas XI DPIB 1 sebagai kelas eksperimen dan XI DPIB 2 sebagai kelas kontrol. Data yang digunakan dalam penelitian ini dikumpulkan melalui instrumen tes dan kuesioner, dan selanjutnya dianalisis dengan menggunakan pendekatan analisis deskriptif kuantitatif serta beragam teknik analisis statistik, termasuk di antaranya analisis NGain, uji t, dan uji Mann-Whitney U. Hasil dari penelitian ini mengindikasikan bahwa penerapan AR dalam proses pembelajaran efektif dalam meningkatkan pemahaman mahasiswa terhadap gambar 2D. Selain itu, terdapat peningkatan signifikan dalam pencapaian hasil belajar siswa di kelas eksperimen jika dibandingkan dengan kelas kontrol. Hasil ini mengungkapkan bahwa penggunaan AR mampu membantu siswa dalam memahami gambar-gambar 2D secara lebih baik, sekaligus meningkatkan hasil belajar mereka pada mata pelajaran konstruksi bangunan dan utilitas. Dengan demikian, penggunaan Teknologi Augmented reality (AR) dapat dianggap sebagai alternatif efektif dalam meningkatkan kualitas pembelajaran siswa, terutama pada mata pelajaran yang memerlukan pemahaman mendalam terhadap gambar, seperti konstruksi bangunan dan utilitas. Oleh karena itu, pengaplikasian AR dapat dianggap sebagai solusi efektif dalam mengatasi kendala pemahaman gambar 2D yang sering dihadapi oleh para mahasiswa
Kontribusi Respon Mahasiswa pada Pembelajaran Micro dan Capaian Pembelajaran (CP) Micro terhadap Capaian Pembelajaran (CP) Praktik Kependidikan di PTSP FT UNY
Authors: Saputri Anggi Agnes , Sutarto Sutarto , Nur Nuzulul Alifin
Published: March 2024

Dalam menghadapi dinamika pendidikan modern, penting bagi kita untuk memahami betapa integralnya peran microteaching dalam membentuk hasil belajar praktik pendidikan. Tujuan penelitian adalah untuk mengetahui: 1) pengaruh reaksi siswa dalam microteaching terhadap hasil belajar praktik pendidikan; 2) pengaruh hasil belajar microteaching terhadap hasil belajar praktik pendidikan; 3) pengaruh reaksi siswa terhadap pengajaran mikro dan hasil belajar pengajaran mikro terhadap hasil belajar praktik pendidikan. Jenis pencarian adalah pencarian sebenarnya. Objek penelitian penelitian ini adalah PTSP FTSP UNY angkatan 2019 yang berjumlah 90 mahasiswa. Sampel sebanyak 40 siswa diperoleh dengan menggunakan teknik purposive sampling. Teknik pengumpulan data menggunakan angket dan dokumen. Validitas instrumen diperiksa dengan validitas konstruk dan validasi isi menggunakan expert review, uji korelasi product snapshot, dan uji reliabilitas menggunakan metode Cronbach’s Alpha. Analisis data dengan statistik deskriptif, pretest dan uji hipotesis menggunakan statistik non parametrik berupa uji Kendal's tau-b dan uji Kendall's W. Hasil penelitian: 1) reaksi mahasiswa terhadap mata kuliah microteaching berpengaruh positif dan signifikan terhadap hasil belajar praktik pendidikan; 2) hasil pengajaran mikro mempunyai pengaruh positif dan signifikan terhadap hasil belajar praktik pendidikan; 3) reaksi mahasiswa terhadap mata kuliah mikro dan hasil Microteaching mempunyai dampak positif dan signifikan terhadap hasil pembelajaran praktik pendidikan. Besarnya koefisien korelasi Kendall tau-b hasil uji parsial masing-masing sebesar 0,513 dan 0,403. Sedangkan nilai uji Kendall W sebesar 0,775 hasil pengujian secara bersamaan.
Kelas Sosial dan Budaya Konsumtif dalam Ruang Lingkup Masyarakat Metropolis dan Tradisional: Teori Perubahan Sosial
Authors: Chrysilla Felita Putri , Komariah Siti , Wulandari Puspita
Published: March 2024

Pengaruh adanya kelas sosial terhadap perilaku konsumen dapat dilihat pada bagaimana seseorang membeli kebutuhan sehari-hari, bagaimana seseorang membeli kebutuhan pokok sehari-hari, atau hanya sekedar dekorasi kelas sosial yang begitu berbeda. Tujuan dari artikel ini adalah untuk mengetahui perubahan sosial yang ada dan kebiasaan konsumsi masyarakat modern, baik tradisional maupun perkotaan, yang membawa tren saat ini. Tujuan utama dari penelitian ini adalah metode penelitian kepustakaan dari buku dan literatur lainnya (library research). Penelitian ini menyebabkan: Kebiasaan konsumsi masyarakat tradisional menekankan keterjangkauan karena kelas sosial mereka lebih rendah. Di sisi lain, kebiasaan konsumsi masyarakat perkotaan lebih tinggi dibandingkan masyarakat tradisional karena kelas sosial yang lebih tinggi. Namun, dengan perubahan sosial saat ini, segalanya terlihat berbeda lagi. Kebiasaan konsumsi masyarakat modern, baik tradisional maupun perkotaan, mengutamakan tren kekinian, tanpa memandang dari kelas ekonomi itu berasal.
Pengaruh Pola Asuh Permisif terhadap Perilaku Konsumtif pada Penggemar BTS (Bangtan Sonyeondan) di Bandung Raya
Authors: Khairani Nadhila Zulfa , Juwitaningrum Ita , Kosasih Engkos
Published: March 2024

Tujuan penelitian ini adalah untuk menguji pengaruh pola asuh permisif terhadap perilaku konsumtif pada penggemar BTS di Bandung Raya dalam membeli merchandise. Sampel dalam penelitian ini menggunakan non-probability sampling dengan teknik accidental sampling. Penelitian ini menggunakan metode kuantitatif dengan jumlah responden 390 orang yang merupakan penggemar BTS di Bandung Raya dan berusia 18-25 tahun. Teknik analisis data pada penelitian ini menggunakan analisis regresi linear sederhana dengan bantuan SPSS. Hasil penelitian menunjukkan bahwa terdapat pengaruh positif dan signifikan pola asuh permisif terhadap perilaku konsumtif. Aspek pola asuh permisif yaitu orang tua kurang kontrol memberikan kontribusi paling besar terhadap perilaku konsumtif subjek penelitian ini.
The role of neutrophil extracellular traps in cancer progression and thrombosis development
Authors: Khizroeva J. Kh. , Aslanova Z. D. , Solopova A. G. , Bitsadze V. O. , Vorobev А. V. , Tatarintseva А. Yu. , Gris J.-С. , Elalamy I. , Makatsariya N. А. , Blinov D. V.
Published: March 2024

Introduction. Initially discovered as a mechanism to protect host neutrophils from pathogens and prevent spread of infection outside inflammatory site, neutrophil extracellular traps (NETs) have been implicated in progression of other diseases associated with sterile inflammation such as autoimmune diseases, diabetes, and cancer. NETs components (myeloperoxidase, citrullinated histones, cell-free DNA) exhibit manifold effects on tumor cells, thereby emphasizing a need to be aware of the features of biological functions related to their constituents and their place in carcinogenesis to identify major molecular targets for targeted therapy of gynecologic cancers in the future.

Aim: to determine an impact of NETs on tumor progression/metastasis and thrombosis risk in gynecologic cancer.

Materials and Methods. A single-center interventional study was conducted: 70 women with uterine, ovarian and cervical cancer were examined; 60 age-matched apparently healthy women without thrombotic complications were selected as controls. All study participants were examined for myeloperoxidase (MРO), citrullinated histone (сitH3), proinflammatory cytokine interleukin-1β (IL-1β), and neutrophil/lymphocyte ratio (NLR).

Results. Laboratory biomarkers such as MPO (p < 0.001), IL-1β (p < 0.001) and NLR (p = 0.003) were significantly more often elevated in patients with oncological pathology compared to group of healthy women. 32 (45.7 %) of the 70 women with cancer of the reproductive system had metastases. Metastases-related analysis in patients showed significant differences in MPO level (p = 0.002), but not in level of citH3, IL-1β and NLR (p = 0.441, p = 0.159, and p = 0.739, respectively). Elevated citH3 vs. MPO, IL-1β and NLR level was significantly more often associated with developing thrombosis in study patients (p < 0.001).

Conclusion. The results of our study demonstrate that inflammation and NETs components such as MPO and citH3 may be potentially implicated in many aspects of carcinogenesis including tumor metastasis and the risk of developing thrombosis in cancer patients.
History of antiphospholipid syndrome
Authors: Drozhzhina М. Р. , Vorobev А. V.
Published: March 2024

Here, we discuss hallmark historical events occurred while investigating antiphospholipid syndrome (APS) particularly describing how lupus anticoagulant was discovered and how scientists around the world came to define APS. The prospects for exploring APS at the present time by applying current APS criteria are considered. The contribution of Russian scientists to APS study and catastrophic APS is outlined.
Effectiveness and safety of the combination drug "Femo-Klim" evaluated in patients with former cancer and moderate menopausal disorders
Authors: Vinogradova О. Р. , Biryuchkova О. А. , Mikheeva S. V.
Published: March 2024

Aim:to assess effectiveness and safety of a combination phytoestrogen-based product “Femo-Klim” in treatment of moderate climacteric disorders in gynecological cancer patients.
Nutrients and environmental toxicants: effect on placental function and fetal growth
Authors: Di Renzo G. C.
Published: March 2024

Understanding the mechanisms by which environmental factors impact reproductive health is crucial for informing public health interventions and policy decisions. By elucidating the pathways through which environmental stressors exert their effects, we can develop targeted strategies to mitigate risks and promote reproductive well-being. In this lecture, we will delve into the latest research findings and emerging trends in the field of environmental reproductive health. By exploring the intricate interplay between environmental exposures and reproductive outcomes, we aim to broaden our understanding of this complex relationship and its implications for human health. Through collaborative efforts across disciplines, we can work towards safeguarding reproductive health for current and future generations.
The role of the microenvironment in tumor growth and spreading
Authors: Bitsadze V. О. , Slukhanchuk Е. V. , Solopova А. G. , Khizroeva J. Kh. , Yakubova F. E. , Orudzhova Е. А. , Degtyareva N. D. , Egorova Е. S. , Makatsariya N. А. , Samburova N. V. , Serov V. N. , Ashrafyan L. А. , Aslanova Z. D. , Lazarchuk А. V. , Kudryavtseva Е. S. , Solopova А. Е. , Kapanadze D. L. , Gris J.-C. , Elalamy I. , Ay С. , Makatsariya А. D.
Published: March 2024

Introduction. The tumor microenvironment (TME) consisting of non-tumor cells and other components plays a crucial role in cancer development by promoting uncontrolled tumor growth.

Aim: to detail all the components in TME and their contribution to carcinogenesis by analyzing available publications.

Results. Currently, TME study is of great interest in the medical field. Its crucial role in the tumor initiation, progression, and spreading is emphasized. Several constituents have been identified in TME including cancer-associated fibroblasts, neutrophils, adipocytes, tumor vasculature, lymphocytes, extracellular matrix, dendritic cells, neutrophil extracellular traps, etc. Thromboinflammatory reactions are also considered an important TME element.

Conclusion. TME constituents can serve as new targets for both diagnostics and antitumor therapy.
Propagation of controlled frontward impulses through standing crowds
Authors: Feldmann Sina , Adrian Juliane , Boltes Maik
Published: March 2024

Impulse propagation in crowds is a phenomenon that is crucial for understanding collective dynamics, but has been scarcely addressed so far. Therefore, we have carried out experiments in which persons standing in a crowd are pushed forward in a controlled manner.Variations of experimental parameters include (i) the intensity of the push, (ii) the initial inter-person distance, (iii) the preparedness of participants and (iv) the crowd formation. Our analysis links the intensity of an impulse recorded by a pressure sensor with individual movements of participants based on head trajectories recorded by overhead cameras and 3D motion capturing data.
The propagation distance as well as the propagation speed of the external impact depends mainly on the intensity of the impulse, whereas no significant effect regarding the preparedness of participants could be found. Especially the propagation speed is influenced by the initial inter-person distance. From the comparison between two methods that detect the time of motion due to the impulse, a more sensitive result is obtained when the velocity of three landmarks of the human body is taken into account and not only the forward displacement of the center of mass. Furthermore, the more intertwined participants are in relation to each other, the more the impulse is distributed to the sides. As a result, more people are affected, however with smaller individual displacements.
Study of methods of energy efficiency improvement considering operation modes of traction electric drive with use of the methods of virtual mathematical modelling
Authors: Klimov Aleksander V.
Published: March 2024

BACKGROUND: Currently, the problem of making wheeled vehicles more environmentally-friendly is one of the most relevant, as using electric vehicles with on-board traction batteries becomes the most popular technical solution. However, the batteries capacity remains relatively low, so efficiency of using them depends on selection the most optimal components of traction electric equipment and implementing the most advanced algorithms of traction electric drive control. Therefore, development of the methods helping to achieve maximal energy efficiency at all stages of design, manufacturing and operation is highly important.
AIM: Development of fundamentals and methods of improvement of wheeled vehicles energy efficiency at the design stage with the use of virtual mathematical modelling.
METHODS: The study was conducted with the MATLAB/Simulink software package.
RESULTS: Theoretical basis of the improvement methods with the use of mathematical modelling of virtual operation of the vehicle’s digital twin in the MATLAB/Simulink is given in the paper.
CONCLUSIONS: The practical value of the study lies in ability of using the proposed methods in development of prosperous wheeled vehicles.