bluuebunny/crossref_metadata_2025 huggingface dataset:
Comunidades indígenas e as línguas de sinais
Authors: Coelho Luciana Lopes , Bruno Marilda Moraes Garcia , Cruz-Aldrete Miroslava
Published: October 2022

Este texto tem como objetivo apresentar dados de pesquisas realizadas pelas autoras no âmbito do Programa de Pós-Graduação em Educação da Universidade Federal da Grande Dourados, Brasil, em parceria com o Centro Interdisciplinário de Investigações em Humanidade da Universidade Autônoma do Estado de Morelos, México. A necessidade de adequação do ensino ministrado em escolas indígenas para a inclusão de estudantes surdos traz à tona questões que envolvem as políticas linguísticas e as políticas de educação especial para estudantes surdos que vivem em comunidades indígenas plurilíngues. Buscou-se conhecer e levantar as múltiplas interfaces entre essas modalidades, enfatizando as línguas, os dispositivos político-normativos e as articulações entre ambas as áreas, sobretudo aqueles produzidos com base no princípio da Educação Inclusiva. A pesquisa foi qualitativa com a orientação teórica dos estudos pós-críticos e a etnografia pós-moderna, no intuito de conhecer e explorar modos alternativos de pensar, falar e fazer determinadas práticas sociais, realizada em contextos específicos, onde são observadas as micropolíticas do cotidiano que constituem e são constituídas pelos discursos dominantes de nossa sociedade. Conhecer as diferentes realidades e práticas de inclusão no Brasil e outros países oportuniza uma melhor compreensão dos cotidianos escolares diversos e plurilíngues, além de permitir se pensar em construir novas e diferentes políticas linguísticas que contemplem as múltiplas realidades vivenciadas pelos sujeitos indígenas surdos.
Desempenho térmico de fachadas ventiladas opacas
Authors: Goulart Mariana Fortes , Labaki Lucila Chebel
Published: October 2022

As fachadas ventiladas têm sido apontadas como uma solução viável para melhoria do desempenho térmico de edifícios, beneficiando, assim, sua eficiência energética. Dentre os diversos tipos desse sistema, a literatura aponta uma escassez de estudos acerca das fachadas ventiladas opacas. Assim, este trabalho tem como objetivo reunir pesquisas sobre o desempenho térmico de fachadas ventiladas opacas por meio da Revisão Sistemática da Literatura (RSL), considerando o local onde as pesquisas foram feitas, o método utilizado e os principais parâmetros que influenciam no desempenho térmico dessas fachadas. A RSL se mostrou eficiente em traçar o panorama desejado, indicando que este modelo de fachada consiste em uma tecnologia explorada apenas recentemente no meio acadêmico, com pesquisas concentradas no continente europeu, principalmente na Espanha, Itália e Portugal, evidenciando o clima mediterrâneo como foco das pesquisas. A maior parte das pesquisas foi realizada com simulações computacionais, seguidos pelos métodos experimentais, que validaram os modelos matemáticos dos programas de simulação. Com a RSL, identificaram-se as condições externas e os aspectos da geometria que mais influenciam no desempenho térmico dessas fachadas. Dentre as condições do meio externo, a radiação solar e as estações do ano foram os parâmetros mais abordados nas pesquisas. Em relação à geometria da fachada, as aberturas na fachada ventilada (presença ou ausência de juntas e grelhas), a altura da cavidade e o material que compõe a camada externa foram as variáveis mais estudadas.
Ethics and professionalism of a community health worker: A virtue ethics approach
Authors: Kumar Ajith , Subramaniam Sudharshini
Published: October 2022

Community health workers are the link between the community and the health system, delivering primary care services at the frontline. Every profession has its own ethics and professional values, and there is a need to formulate the ethics of community health work which should be informed by their rich experiential wisdom. In one such effort, we interviewed a senior community health worker in the Tamil Nadu health system and present it here as a virtue ethics case study. Several situations of ethical conflict arising in her work, and her process for resolving these conflicts were discussed during the interview. The worker discussed some ethical principles: doing good, not doing any harm, maintaining justice, being honest, providing respectful care, maintaining self-respect, being accessible, earning the community's trust, and building solidarity. This interview confirms the assumption that ethics and professionalism are inherent in this community health worker, and emphasises the need for systematic research to document the experiences of such frontline workers, and to frame relevant standards of ethics and professionalism in the local context.
The anomalous measurements selection in primary processing for the orbit determination from the «Kobalt-R» ground station trajectory information.
Authors: Tuchin Denis Andreevich
Published: October 2022

Algorithms for deciphering measurements, celestial-mechanical interpretation of the requested measurements of the range and radial velocity are presented. The method of the anomalous measurements rejection during their preliminary processing is presented.
Bir Çeviribilimci Olarak Münif Paşa
Authors: GÜNÇE Şuheda
Published: October 2022

On dokuzuncu yüzyılda Batı ile artan ilişkiler sonucunda tercüme faaliyetleri oldukça önem kazanmaya başlamıştır. Bilhassa Tanzimat döneminde dil öğrenmeye büyük bir teveccüh gösterilmiş kimisi devlet eliyle açılmış olan Tercüme Odası’na giderken, kimisi de yurtdışında eğitim alma ve kendini geliştirme yolunu tercih etmiştir. Yazılı basının gelişmesiyle birlikte kendini yetiştirmiş olan Osmanlı aydınları dönemin gazete ve dergilerinde bir taraftan Türkçe yazılar kaleme alırken bir taraftan da Batı’da yayımlanmış çeşitli eserlerden tercümeler yapmaya başlamışlardır. Başta Arapça ve Farsça olmak üzere Fransızca, Almanca, İngilizce bilen ve ömrünün sonlarına doğru Çince öğrenmeye başlayan Münif Paşa da tercüme noktasında çok yönlü bir kişilik olarak karşımıza çıkmaktadır. Bu çalışmada, Münif Paşa eliyle çıkarılan ilk bilim ve fen dergisi olarak kabul edilen Mecmua-i Fünun’da ve dönemin diğer süreli yayınlarında yaptığı tercümeler üzerinden Münif Paşa’nın tercüme programı analiz edilecek ve onun yapmış olduğu tercümelerin kültür dünyamıza katkıları incelenecektir. Çalışmada kullanılan bilgiler, çoğunlukla Cumhurbaşkanlığı Osmanlı Arşivi’nde bulunan evraklar ve dönemin süreli yayınlarından elde edilmiştir.
Atlantoaxial Spondyloptosis with Type II Odontoid Fractures
Authors: Lachance Andrew D. , Gerstl Jakob V. E. , Florman Jeffrey E.
Published: October 2022

Case:

Two patients with delayed presentations of neck pain and fixed kyphotic deformity after trauma were found to have atlantoaxial spondyloptosis (AAS) with type II dens fractures. Owing to the rarity of AAS, outcomes and optimal treatment are not well understood. In both cases, closed reduction was achieved with a dynamic overhead traction setup, followed by posterior surgical stabilization with C1-2 screw fixation.

Conclusion:

Closed reduction remains a challenge because of the marked deformity of interlocking C1-C2 joints. However, patients with chronic fixed atlantoaxial dislocation due to odontoid fractures can be safely managed with closed reduction and fusion of C1-C2.

Level of Evidence:

Level V.
Respiratory Failure After Supraclavicular Nerve Block in a Patient With a Contralateral Brachial Plexus Injury
Authors: Crowe Christopher S. , Pulos Bridget P. , Spinner Robert J. , Shin Alexander Y.
Published: October 2022

Case:

A patient with prior left-sided brachial plexus trauma and associated left phrenic nerve paralysis subsequently developed transient respiratory failure after a contralateral supraclavicular nerve block. Her known left phrenic nerve palsy secondary to her index brachial plexus injury was rediscovered during the workup of her acute respiratory distress, which resulted in an emergent intensive care unit admission.

Conclusion:

The paralysis of her right phrenic nerve at the time of left-sided regional anesthesia was identified as the etiology of near-complete bilateral diaphragmatic paralysis and respiratory failure.
Karakterisasi Morfoanatomi Adiantum spp. Koleksi Kebun Raya Purwodadi
Authors: Renjana Elga , Andiana Jocelin
Published: October 2022

Adiantum spp. yang dikenal sebagai suplir merupakan tanaman hijau sepanjang tahun dan memiliki keragaman spesies yang tinggi yaitu lebih dari 200 spesies. Karakteristik Adiantum spp. terdapat pada daun majemuk dengan ukuran anak daun (pinnule) yang kecil dan bentuknya beragam dengan sori di bagian tepi abaksial daun, serta memiliki tangkai ental (stipe) berwarna hitam. Kebun Raya Purwodadi (KRP) memiliki koleksi lima spesies Adiantum spp., yaitu Adiantum caudatum, A. concinnum, A. cunninghamii, A. hispidulum, dan A. peruvianum. Penelitian ini bertujuan untuk mengkarakterisasi secara morfologi dan anatomi lima spesies Adiantum spp. koleksi KRP. Penelitian ini dilakukan pada bulan Oktober hingga November 2021 dengan mengamati dan men-deskripsikan karakter morfologi dan anatomi kelima spesies koleksi Adiantum spp. Analisis data dilakukan secara deskriptif kualitatif. Hasil penelitian menunjukkan bahwa kelimanya memiliki persamaan karakter pada permukaan tangkai ental, warna sisik, tipe indusium, bentuk spora, dan tipe stomata. Selain itu, terdapat pula karakter yang menjadi pembeda antar lima spesies Adiantum spp., yaitu ukuran tanaman, keberadaan sisik pada ental (frond), warna tangkai ental, tipe percabangan, panjang rakis, ukuran, bentuk, kedalaman toreh, jumlah, dan warna anak daun, bentuk dan susunan sel sisik, ukuran dan warna fiddlehead, jumlah dan ukuran spora, serta jumlah stomata. Hasil penelitian ini diharapkan dapat memberikan peran yang berharga untuk studi biologi serta dapat menjadi informasi dasar dalam melakukan identifikasi spesies tumbuhan paku.
Co2SnO4@Co3O4-SnO2 composite for enhanced peroxymonosulfate activation: Catalytic degradation of diclofenac, mechanism and degradation pathways
Authors: FERGANI Soumia , ZAZOUA Hanane , SAADI Adel , TOUATI Souad , BOUDJEMAA Amel , BACHARI khaldoun
Published: October 2022

Co2SnO4@Co3O4-SnO2 catalyst was successfully prepared via co-precipitation method. The physico-chemical properties of the resulting powder were determined by X-ray diffraction (XRD), infrared attenuated total reflectance spectroscopy (IR-ATR), N2 adsorption/desorption, scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). The material was tested for the catalytic degradation of diclofenac (DCF) by activating the peroxymonosulfate (PMS). Several parameters such as the catalyst amount, PMS and DCF concentrations were optimized. The experiment results revealed that Co2SnO4@Co3O4-SnO2-PMS system showed a good catalytic performance. Indeed, DCF was completely degraded within 2 min under optimal conditions. Radical scavenging experimental results showed that singlet oxygen 1O2 was identified as the only reactive species during the catalytic degradation of DCF. Finally, a possible degradation pathway was proposed based on the intermediates identified using liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS).
Broad Spectrum Antifungal Activity and Anticancer Potential of Secondary Metabolites from Cave Soil Streptomyces sp. strain YC69
Authors: Bhat Meghashyama Prabhakara , Nayaka Sreenivasa
Published: October 2022

Cancer is one of the fatal diseases and has high mortality worldwide. The major drawback with the cure is the side effects from the chemotherapeutic agents, and there is an urgent need for an alternative. Actinomycetes from cave soil were isolated, and the crude extract obtained from the potent isolate was analyzed with GC-MS and HPTLC to identify bioactive metabolites. The crude extract was examined for in-vitro antimicrobial and antifungal activity on plant pathogens. The isolate Streptomyces sp. strain YC69 exhibited antagonistic activity and increased antimicrobial activity in a dose-dependent manner, with the highest inhibition observed in S. aureus. GC-MS revealed many bioactive compounds, and HPTLC depicted metabolite fingerprints. The antifungal activity exhibited a delayed lag phase in growth curve assay and distorted and collapsed cells of Fusarium oxysporum in SEM micrograph. The results from the current study suggest that the crude extract from Streptomyces sp. strain YC69 contains antimicrobial metabolites that can inhibit pathogenic microbes, which cause severe diseases in plants and humans. The MTT assay results conclude that further studies on purification may lead to the use of Streptomyces sp. strain YC69 as a source for anti-oncogenic compounds.
Gains and Losses: A Phenomenographic Study on Adolescents’ Understanding of Isolation due to COVID-19
Authors: Rosali Leann Jester , Erojo Kreen , Dicto Princess Joy
Published: October 2022

The global health emergency posed by the COVID-19 outbreak has affected millions of people. In the Philippines, among the establishments closed are schools that resulted in children and adolescents staying at home for years under quarantine. Many studies were conducted focusing on the impact of isolation on people's physical and emotional well-being, most notably the children and adolescents who are considered vulnerable individuals. However, limited studies investigated how these young people understand their experiences while in quarantine. Hence, this phenomenographic study aims to provide insights into Filipino adolescents' realities by exploring the many different ways they view isolation. Seventeen adolescents in quarantine were interviewed, and qualitative analysis revealed a dualist outcome space where isolation is seen in the light of gains and losses. Eight sub-themes describing the three emerging themes are reported. The descriptions reveal understandings that isolation is (1) a restraint, (2) a necessity, and (3) an opportunity that has an impact on the physical, emotional, and social dimensions of adolescents' lives. Implications and recommendations presented may serve as a basis for designing programs and interventions to help adolescents deal with possible negative feelings in isolation and post quarantine.
Low-cost climate-change informational intervention reduces meat consumption among students for years
Authors: Jalil Andrew , Tasoff Joshua , Bustamante Arturo Vargas
Published: October 2022

Using a dataset of more than 100,000 meal selections over three years, we examine the long-term effects of an informational intervention designed to increase awareness about the role of meat consumption in climate change. Students randomized to the treatment group reduced their meat consumption by 5.6 percentage points with no signs of reversal. Calculations indicate a high return on investment (conservative estimate: ~$14 per metric ton CO2eq). Our findings suggest that informational interventions can be cost-effective and generate long-lasting shifts towards more sustainable food options.
MEBOCOST: Metabolite-mediated Cell Communication Modeling by Single Cell Transcriptome
Authors: Chen Kaifu , Zheng Rongbin , Zhang Yang , Tsuji Tadataka , Gao Xinlei , Shamsi Farnaz , Wagner Allon , Yosef Nir , Chen Hong , Zhang Lili , Tseng Yu-Hua
Published: October 2022

We developed MEBOCOST, an algorithm for quantitatively inferring metabolite-mediated intercellular communications using single-cell RNA-seq data. The algorithm identifies cell-cell communications in which metabolites, such as lipids, are secreted by sender cells and traveled to interact with sensor proteins of receiver cells. The sensors on the receiver cell include the cell surface receptors, transporters across the cell membrane, or nuclear receptors. MEBOCOST relies on a comprehensive database of metabolite-sensor partners, which we manually curated from the literature and other public sources. MEBOCOST defines sender and receiver cells for an extracellular metabolite based on the expression levels of the enzymes and sensors, respectively, thus identifies metabolite-sensor communications between the cells. Applying MEBOCOST to mouse brown adipose tissue (BAT) successfully recaptured known metabolite-mediated cell communications and further identified new communications. Additionally, MEBOCOST identified a set of intercellular metabolite-sensor communications regulated by cold exposure in mouse BAT. MEBOCOST will be useful to researchers for investigation of metabolite-mediated cell-cell communications in many biological and disease models. The MEBOCOST software is freely available at https://github.com/zhengrongbin/MEBOCOST.
Enhanced clinical assessment of hematologic malignancies through routine paired tumor:normal sequencing
Authors: Ptashkin Ryan Ryan N. , Ewalt Mark , Jayakumaran Gowtham , Kiecka Iwona , Bowman Anita , Yao JinJuan , Casanova Jacklyn , Lin Yun-Te David , Petrova-Drus Kseniya , Mohanty Abhinita , Bacares Ruben , Benhamida Jamal , Rana Satshil , Razumova Anna , Vanderbilt Chad , Rema Anoop Balakrishnan , Rijo Ivelise , Son-Garcia Julie , de Bruijn Ino , Zhu Menglei , Lachhander Sean , Wang Wei , Haque Mohammad , Seshan Venkatraman , Wang Jiajing , Liu Ying , Nafa Khedoudja , Borsu Laetitia , Zhang Yanming , Aypar Umut , Suehnholz Sarah , Chakravarty Debyani , Park Jae , Abdel-Wahab Omar , Mato Anthony , Xiao Wenbin , Roshal Mikhail , Yabe Mariko , Batlevi Connie , Giralt Sergio , Salles Gilles , Rampal Raajit , Tallman Martin , Stein Eytan , Younes Anas , Levine Ross , Perales Miguel-Angel , Brink Marcel van den , Dogan Ahmet , Ladanyi Marc , Berger Michael , Brannon Angela Rose , Benayed Ryma , Zehir Ahmet , Arcila Maria
Published: October 2022

Genomic profiling of hematologic malignancies has augmented our understanding of variants that contribute to disease pathogenesis and supported development of prognostic models that inform disease management in the clinic. Tumor only sequencing assays are limited in their ability to identify definitive somatic variants, which can lead to ambiguity in clinical reporting and patient management. Here, we describe the MSK-IMPACT Heme cohort, a comprehensive data set of somatic alterations from paired tumor and normal DNA using a hybridization capture next generation sequencing platform. We highlight patterns of mutations, copy number alterations, and mutation signatures in a broad set of myeloid and lymphoid neoplasms. We also demonstrate the power of appropriate matching to make definitive somatic calls, including in patients who have undergone allogeneic stem cell transplant. We expect that this resource will further spur research into the pathobiology and clinical utility of clinical sequencing for patients with hematologic neoplasms.
Transcriptome Sequencing Unveils Immune Heterogeneity between Systemic Immune Response and the Liver Immune Microenvironment along HBV-ACLF Development
Authors: Chen Mo , Lin Fanghe , Zhang Senquan , Yu Yeping , Li Zhe , Zhang Yingkun , Xi Zhifeng , Qian Yongbin , Yang Chaoyong , Xia Qiang , Song Jia , Hang Hualian
Published: October 2022

Background
The COSSH-ACLF criteria provides a grading system feasible for Chinese ACLF population featured with HBV infection background. However, insufficient mechanical foundation is available for the grading system. In the present study, we aimed to explore the status of the liver microenvironment as well as circulating immune components of HBV-ACLF patients and to establish metabolic biomarkers representing immune phenotypes corresponding to COSSH-ACLF grades.
Methods
Transcriptome sequencing on liver-infiltrated CD45+ immune cells and PBMCs from HBV-ACLF patients were applied. ACLF mouse models were constructed with chronic CCl4 administration combined with instant K.P. induction.
Results
We revealed the most prominent turbulence in immune and metabolism modules along the development of the disease. Immune profiling analysis revealed a generally exhausted liver immune microenvironment. Significant immune heterogeneity of the liver microenvironment was observed compared with immune response in circulation, manifesting that antigen presentation in innate immune response was notably inhibited. Lipid metabolism-associated turbulence was noted in liver. We established a 3-biomarker signature depicting the metabolic-induced immune turbulence of HBV-ACLF. APOE induced cholesterol efflux may play an essential role in Kupfer cell polarization along HBV-ACLF deterioration, which can be reversed by rosuvastatin.
Conclusions
The results identified that the featured immune phenotypes in the liver microenvironment were potentially related to lipid metabolic turbulence in HBV-ACLF development, highlighting the presence of novel immune heterogeneity among different COSSH-ACLF grades, as well as between that between circulation and liver focal microenvironment.
Non-phthalate Plasticizer/ Poly (vinyl chloride) Compound for Sustainablty based on biomaterials Using Glycerol From Biodiesel Process
Authors: Soliman Aya , Anwar Abbas , Anwar Hossam , morsy Ashraf
Published: October 2022

The phthalate replacement trend the globe began when the European Union put a ban on dioctyl phthalate(DOP) and other. This trend will continue as environmental and sustainability concerns increase. These polymers, made from renewable sourced (plant based) raw material, as bio-based development plasticizers to gain some functionality. At the same time, the biodiesel sector produces an excess glycerol, prompting scientists to look for new uses for this material. The main goal is to create a non-phthalate plasticizer for poly (vinyl chloride) (PVC) utilizing crude glycol from the biodiesel process, corn starch (S), sunflower oil, citric acid(C) and Benzoic acid(B). Glycerol diacetomonolaurate plasticizer will be developed utilizing glycerol from the biodiesel process. Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) will be used to examine the plasticizer production, A universal testing equipment will be used to determine the mechanical properties of the plasticizer-PVC compound, Thermal gravimetric analysis (TGA) and the experimental values will be compared with phthalate plasticizer-PVC compound. The plasticizing performances of the sampleof non- phthalate contain (SCB (3)) rivaled that of (DOP) phthalate, from this study suggesting that they have the potential to replace phthalate in soft PVC materials.
Financial socialization, strength of social ties and investment literacy of investors in P2P lending platforms
Authors: Legenzova Renata , Leckė Gintarė , Gaigalienė Asta
Published: October 2022

This study explores survey data of investors in peer-to-peer (P2P) lending platforms to assess their investment literacy, to explore how this literacy is affected by their financial socialization and the strength of their social ties, and to question whether this effect differs among investors’ sociodemographic groups.
Our research revealed that the investment literacy of P2P lending platform investors is high and rejects a common perception that investors in P2P lending platforms have a low level of investment literacy. Significant sociodemographic determinants of investment literacy are investor gender, age, net income, and interface with the finance sector. As for financial socialization, peers showed to be the main socialization agent and demonstrated the strongest social ties with our respondents. The compound direct effect of financial socialization on the aggregated level of investment literacy of P2P lending platforms’ investors was positive and stronger than that on its separate components. Although the strength of social ties had a strong influence on financial socialization, its indirect effect on investment literacy was rather weak. The average P2P lending platform investor whose investment literacy is shaped by financial socialization and reinforced by the strength of his or her social ties was shown to be an 18- to 34-year-old person (man or woman) working in the financial sector with a net monthly income below 1500 euro.
Such results show that for innovative financial services, compound financial socialization is an important mean to “fill in the gaps” in investment literacy. The results could be used by market regulators, innovative service providers and educators in the development and promotion of innovative financial products and product-related investment literacy programs.
JEL classification: G41, G53.
The future of Iberian droughts: a deeper analysis based on multi-scenario and a multi-model ensemble approach
Authors: Soares Pedro , Careto João , Russo Ana , Lima Daniela
Published: October 2022

As a result of warming and precipitation deficits, the increasing shortage of water resources and droughts have become one of the main drivers of desertification, land degradation and food insecurity with direct impacts on ecosystems and society, especially in fragile communities. Over the Iberian Peninsula, a known climate change hotspot, the occurrence of droughts varies in intensity and severity, being its assessment under present and future conditions an important asset for adaptation measures. Here, for the first time, we present a comprehensive analysis of the different plausible evolutions of droughts throughout the 21st century over Iberia at a monthly basis, featuring three different emission scenarios (RCP2.6, RCP4.5, RCP8.5). A multi-variable, multi-model EURO-CORDEX weighted ensemble is used to assess the future drought conditions using the SPI (Standardized Precipitation Index) and SPEI (Standardized Precipitation Evapotranspiration Index). All indexes were computing by considering the full period, from 1971 to 2000 merged with the 2011–2100 period from each RCP scenario. The results clearly show that Iberian Peninsula is greatly vulnerable to climate change, indicating a significant increase in intensity and severity of drought occurrences, even for the low-end RCP2.6 scenario. For the RCP4.5 and RCP8.5 scenarios, the increases are more pronounced and enhanced throughout the 21st century, from 3 up to 12 more severe droughts for the shorter timescales with increases in mean duration above the 30 months for the longer accumulation periods The use of all the RCPs data pooled together with a weighted ensemble approach allows not only a more accurate projection of future droughts, but also ensures comparability among the projections from the three RCP scenarios. The future drought evolution aspires to assist the new Portuguese national roadmap for adaptation for the 21st century, bridging the water sector challenges from mitigation to adaptation in a dynamic way.
A Tunisian social accounting matrix for impact analysis of macroeconomic policies and shocks
Authors: Salhi Jabeur , BENAMMOU Saloua
Published: October 2022

The instability caused by the events of 2011, combined with the global economic crisis, caused problems on all levels for Tunisia, hence the need for a comprehensive data framework that consists of a social accounting matrix to assist the government in policy formulation. We used cross-entropy to balance a matrix with data collected mainly from the integrated economic accounts table, the supply-use table, and other sources. We have constructed a matrix with definitive data at the macro-economic and micro-economic levels to offer a coherent and complete representation of the economic and social system while reflecting the interdependencies of institutional groups. This matrix is used as a database in a recursive dynamic computable general equilibrium model to assess the impact on economic growth and reducing unemployment of a policy of increasing public spending on infrastructure investment. The Tunisian matrix can allow decision-makers to orient their choice, and supervise social policies and their link with economic development.
JEL: (E16), (E24), (E6), (H5)
Diagnostic nomogram for distant metastasis in newly diagnosed colorectal cancer based on clinical features
Authors: Jianghua He , Cao Cong , Ding Yang , Yi Yun , Lv Yuqing , Wang Chun , Chang Ying
Published: October 2022

Background
Colorectal cancer is one of the most common primary malignancies and the third most common cause of cancer death in both men and women in the United States. Among people diagnosed with initial colorectal cancer, 22% had metastatic colorectal cancer, while the 5-year survival rate was less than 20%.
Methods
We retrospectively reviewed the data of patients who were diagnosed as Colorectal cancer in Zhong nan Hospital of Wuhan University and People's Hospital of Gansu Province between January 2016 and December 2021.Risk predictors for distant metastasis from colorectal patients were determined by the univariate and multivariate logistic regression analysis. Nomograms were developed to predict the probabilities of distant metastatic sites of Colorectal cancer patients and evaluated by calibration curves, receiver operating characteristic (ROC) curve, and decision curve analysis (DCA).
Results
A total of 327 cases were included in this study, 224 colorectal cancer patients from Zhong nan Hospital of Wuhan University were incorporated into the training set, and 103 colorectal cancer patients from Gansu Provincial People's Hospital were incorporated into the testing set. By univariate logistic regression analysis, platelet level (PLT) (p = 0.009), CEA level (p = 0.032), histological grade (p < 0.001), colorectal cancer tumor markers (p < 0.001) and N stage (p < 0.001), tumor site (p = 0.013) were associated with distant metastasis in colorectal cancer patients. The C-indexes for the prediction of the nomogram were 0.898(95% confidence interval (CI), 0.851–0.945).
Conclusions
The nomogram showed excellent accuracy in predicting distant metastatic sites and clinical utility may facilitate clinical decision-making.
A rapid forecast method for the process of flash flood based on hydrodynamic model and KNN algorithm
Authors: Zhou Nie , Hou Jingming , Chen Hua , Chen Guangzhao , Liu Bingyi
Published: October 2022

Using hydrodynamic models to carry out early warning and forecasting of flash floods is an essential non-engineering measure to reduce the loss. However, most current hydrodynamic models have insufficient forecasting timeliness. To address this issue, a method based on the hydrodynamic model and the K nearest neighbours (KNN) algorithm is proposed to realize a rapid forecast for the process of flash floods. With the rainfall sequence as the input data and the simulation results of the hydrodynamic model as the target data, the rapid forecast of water depth, water velocity and discharge are achieved. Taking the Baogai Temple Basin as the study area, the rapid forecast model (RFM) is established, and its reliability and timeliness are verified. The results suggest that the established model has high accuracy, with 99% of the test data able to control the error of accumulated inundation extent within 20% and the NSE value of the cross-sectional discharge reaching 0.98. For 75% of rainfall scenarios, the maximum average water depth and velocity error of the cross-sections can control within 7.5% and 10%, respectively. It also has dramatically improved calculation time, and can complete the prediction of the flooding process for the next 10 hours within 25s. It can gain valuable lead time for emergency decision-making and has broad application prospects in dealing with flash floods.
N-Formimidoylation/-iminoacetylation requires a specialized enzyme employing FAD-dependent and ligand-protein NOS bridge dual chemistry
Authors: Li Tsung-Lin , Wang Yung-Lin , Chang Chin-Yuan , Hsu Ning-Shian , Lo I-Wen , Lin Kuan-Hung , Chen Chun-Liang , Chang Chi-Fon , Wang Zhe-Chong , Ogasawara Yasushi , Dairi Tohru , Maruyama Chitose , Hamano Yoshimitsu
Published: October 2022

Oxidized cysteine residues are highly reactive and may form covalent conjugates with other residues in proteins to enable proper functionalities, for example, the lysine-cysteine NOS bridge identified recently as an allosteric redox switch. To our knowledge, the NOS-covalent species per se directly engaging in reactions has not been previously demonstrated. Here, we report a non-canonical FAD-dependent enzyme Orf1 that adds a glycine-derived N-formimidoyl group to glycinothricin forming BD-12, an enzymatic process demanding a cascade of delicate chemical reactions. To illustrate how it proceeds, we pursed X-ray crystallography whereby crystal complexes display two tetrameric oligomers in an asymmetric unit. Unlike canonical FAD-dependent oxidoreductases, two substrate-binding sites that sit 13.5 Å apart were uncovered one for glycine and the other for glycinothricin/glycylthricin. An intermediate-enzyme adduct in an NOS-covalent linkage was spotted at the latter, where it acts as though a two-scissile-bond linkage rod permits nucleophilic addition and cofactor-free decarboxylation reactions to take place. The chain length of nucleophilic acceptors contends with bond cleavage sites at either N–O or O–S accounting for N-formimidoylation or -iminoacetylation. The resultant is no more sensitive to aminoglycoside-modifying enzymes, an acute strategy that antibiotic-producing species employs to reinvigorate its armory countering drug resistance of competing species.
Synthesis and Characterization of Iron Doped Hydroxyapatite for Defluoridation of Water and Antibacterial Activity
Authors: Temtime Abebe Awulew , Zereffa Enyew Amare , Leku Dereje Tsegaye
Published: October 2022

Fluoride contaminated drinking water is a major concern due to its negative health effects experienced by people in many parts of the world. This study focused on the synthesis of HAp and Fe doped HAp from diammonium hydrogen phosphate (DAP), calcium and iron precursors using urea as fuel for defluoridation of water and antibacterial activities. The synthesis of HAp and Fe doped HAp were characterized by using thermogravimetric analysis; scanning electron microscopy, X-ray diffraction, and Fourier transform Infrared spectroscopic techniques. An average crystallite size of HAp and Fe doped HAp were 32.54 nm and 27.91 nm, respectively, showing Fe doping results in a decrease in crystallite size. Batch adsorption studies were performed to investigate the adsorption capacity and removal efficiency of hydroxyapatite such as the effect of the initial pH of the solution, contact time, adsorbent dose and initial fluoride concentration. The adsorption data were fitted by Freundlich isotherm model and pseudo second order kinetic. In real water samples, the maximum removal efficiency of fluoride was observed to be 82.9 % with 4.2 mg/g maximum adsorption capacity under the optimum conditions which indicated that the prepared hydroxyapatite can be used as adsorbents for the removal of fluoride from contaminated real water with good efficiency. The antibacterial activities of the synthesized HAp and Fe doped HAp were tested against gram-negative bacterial strains E. coli and against gram-positive bacterial strains S. aureus using disc diffusion method. The maximum inhibition zone of gram-negative bacterial strains E. coli was 11 mm for both HAp and Fe doped HAp.
Bayesian hypothesis testing reveals that reproducible models in Systems Biology get more citations
Authors: Höpfl Sebastian , Pleiss Jürgen , Radde Nicole
Published: October 2022

Many measures have been taken to develop data and modeling standards towards a F.A.I.R. data and model management by the Systems Biology community. Still, there is an ongoing debate about incentives and merits for the individual researcher to make their research results reproducible. Here, we pose the specific question whether reproducible models have higher impact in terms of citations. Therefore, we statistically analyze 328 published models which were recently classified by Tiwari et al. based on their reproducibility. For hypotheses testing, we use a flexible Bayesian approach that provides full distributional information for all quantities of interest and can handle outliers. The results show that in the period from 2013, i.e. 10 years after the introduction of SBML, to 2020, the group of reproducible models is significantly more cited than the non-reproducible group. We show that this effect is not explained by differences in journal impact factors and that it increases with additional standardization of data and error model integration via PEtab. Overall, our statistical analysis demonstrates long-term merits of reproducible modeling for the individual researcher in terms of citations. Moreover, it provides evidences for an increased use of reproducible models in the scientific community.
The use of impulse oscillometry system for monitoring of lung mechanics during covid-19 pneumonia
Authors: Taivans Immanuels , Grima Laura , Zvaigzne Ligita , Jurka Normunds , Gordjusina Valentina , Strazda Gunta
Published: October 2022

Forced oscillation technique (FOT) is non-invasive method, that does not require the patient's participation and allows to evaluate lung and airways mechanics. The question addressed by the study is whether Computerized Tomography (CT) and FOT data correlate between and whether FOT allows to follow up the course of covid-19 pneumonia during the acute intrahospital and recovery period. Material, patients and methods In the study were involved 30 intrahospital treated spontaneously breathing, oxygen dependent patients with moderate severity SARS-CoV-2 induced pneumonia. (CT) scans were quantitatively assessed by CT-scoring method. During the hospital stay and 3 months after the discharge lung function was measured by FOT method. Results During acute period resistance values R5 and R5-20 were elevated above the upper limit of normal (ULN) in 28% and 50% of all patients respectively. Reactance indices X5, AX and Fres exceeded ULN in 55%, 68% and 66% of cases. Significant correlations were observed between PaO2/FiO2, the time spent in the hospital and R5, X5, AX and Fres expressed as % of predicted. Significant correlations between FOT indices and CT-score was not found. After 3 months 18 patients were compared. R5-20 from 316;-171/+583 decreased to 122;- 56/+266% pred. P = 0,0075. AX from 448;- 275/+731 decreased to 213;- 131/+347% pred,p = 0,0112 and Fres from 171;- 143/+200 to 130;- 110/+150%pred, p = 0,0081. Study has shown that FOT method reliably reflects the pathological changes in lung mechanics and allows to monitor the course of covid-19 disease, but it cannot substitute for CT.
Vector coding reveals the underlying balance control strategies used by humans during translational perturbation
Authors: Taleshi Naser , Brownjohn James , Lamb Sarah E , Zivanovic Stana , Williams Genevieve
Published: October 2022

Postural control research has mainly focused on standing balance experiments on a platform moving with relatively large amplitudes (0.1-0.2 m). To broaden knowledge about postural coordination, this study investigated balance strategies while standing on a platform moving in the anterior-posterior direction and whose frequency was scaled linearly from 0.4-6 Hz at a small amplitude of 2 mm peak. The coordination between hip, knee, and ankle joint torque, and centre of mass (COM) and centre of pressure (COP) motion was quantified by vector coding (VC) method to define the local and global strategy, respectively. VC revealed that at lower frequencies, an ankle strategy was recruited which induced an in-phase COPCOM motion with COP dominancy. As platform frequency reached a critical value, the transition frequency, COM dominated over COP and an anti-phase torque occurred between the knee and ankle, called a knee strategy. The knee strategy related to an anti-phase motion between the COP and COM and allowed the COP to regain its dominance over COM. Collectively, this work revealed the knee strategy as a new balance control strategy relevant in real-life settings, and a transition between ankle and knee strategies that underpinned a transition between COP-COM relative motion.
Ephemeral Learning - Augmenting Triggers with Online-Trained Normalizing Flows
Authors: Butter Anja , Diefenbacher Sascha , Kasieczka Gregor , Nachman Benjamin , Plehn Tilman , Shih David , Winterhalder Ramon
Published: October 2022

The large data rates at the LHC require an online trigger system to select relevant collisions. Rather than compressing individual events, we propose to compress an entire data set at once. We use a normalizing flow as a deep generative model to learn the probability density of the data online. The events are then represented by the generative neural network and can be inspected offline for anomalies or used for other analysis purposes. We demonstrate our new approach for a toy model and a correlation-enhanced bump hunt.
Corporate green Sukuk issuance for sustainable financing in Indonesia
Authors: Endri Endri , Tahya Hania Bella , Ma’ruf Amir
Published: October 2022

Green Sukuk is a source of financing that supports the SDGs. Climate change, the growth of the Islamic finance industry, and the rise of socially responsible investing could make green Sukuk a vital tool for financing clean energy and sustainable infrastructure projects. Many studies have identified its potential and advantages. However, no companies have issued green corporate Sukuk in Indonesia yet. The purpose of this study is to determine the potential and main problems of issuing corporate green Sukuk in Indonesia, along with possible solutions and strategies. The research method used is the analytic network process (ANP). In this study, respondents are experts in the field of green Sukuk (involved experts were from academia, project actors, and regulators). The results of the study indicate that the first destination that has the potential to be financed with green corporate Sukuk is renewable energy. At the same time, the main problem is the lack of understanding from market participants. In terms of solutions, the incentive provided by the government is the best to encourage the issuance of green corporate Sukuk. Moreover, the first strategy is to issue green corporate Sukuk with ijarah contracts. From the research results, it is hoped that the Indonesian government can be more aggressive in providing incentives to green project actors.
Efficacy and safety of ustekinumab therapy in patients with Crohn’s disease. Real clinical practice
Authors: Knyazev O. V. , Kagramanova A. V. , Lischinskaya A. А. , Li I. А. , Sabelnikova E. А. , Demchenko A. N. , Nanaeva B. А. , Zhulina E. Yu. , Kamzarakova N. V. , Chebotareva M. V. , Fadeeva N. А. , Nikolskaya K. А.
Published: October 2022

Introduction.The results of registrational clinical trials (CTs) and real clinical practice do not always correlate. The task of practitioners is to find optimal approaches to the therapy of Crohn’s disease, based on the analysis of clinical trials and real-world data.Aim.To make a retrospective assessment of the efficacy and tolerability of UST therapy in patients with moderate to severe CD in real clinical practice.Materials and methods.A total of 88 patients with CD were included in the study to evaluate the efficacy and safety of UST. Among the patients, men accounted for 48.9%, women – 51.1%, the average age was 36.4 ± 4.8 years, the disease duration was 7.8 ± 2.1 years. 67.1% of patients with moderate CD in the form of ileocolitis (82.9%) had a stenosing (26.1%) and penetrating (50.0%) form of the disease. 95.4% of patients received prior immunosuppressive therapy.Results.After inductive therapy with UST, clinical response and clinical remission within 8 weeks were recorded in 86 (97.7%) patients with CD. After 26 weeks, 58 (65.9%) patients achieved clinical remission, 28 (31.8%) patients with CD and all patients who responded to UST therapy maintained clinical response. Crohn’s Disease Activity Index (CDAI) decreased from 445.8 ± 50.4 to 134.6 ± 21.4 points. Clinically significant endoscopic improvement was reported in 25 (40.3%) of 62 patients, endoscopic response in 14 (22.6%) patients, endoscopic remission in 18 (29.0%). After 26 weeks, CDAI decreased from 7.8 ± 1.8 to 2.9 ± 1.2 points, after 52 weeks it decreased from 445.8 ± 50.4 to 141.6 ± 28.2. Steroid-free remission in CD patients accounted for 68.2%. 1-year survival of UST therapy was 97.7%, 2-year survival was 95.5%.Conclusions.The observation demonstrated the high efficacy of the drug in induction and maintenance therapy in the cohort of patients with severe to moderate CD resistant to disease-modifying and genetically engineered biological drugs.
Efficacy of an esophageal mucosal protectant in the treatment of patients with gastroesophageal reflux disease: a systematic review
Authors: Maev I. V. , Andreev D. N. , Kucheryavyy Yu. A. , Lobanova E. G. , Shefer D. I.
Published: October 2022

Gastroesophageal reflux disease (GERD) is one of the most widespread gastrointestinal pathologies and the most common reason for seeking medical care at the level of a primary link of public health services in many countries around the world. The classic clinical presentations of GERD are heartburn, belching, and regurgitation (spitting up), but the overall spectrum of GERD symptoms is broader and more heterogeneous in scope, including extraesophageal symptoms. Clinical and/or endoscopic refractoriness of some patients to the standard proton pump inhibitors (PPIs) therapy remains a global challenge in the management of patients with GERD at the current stage of clinical medicine development. A medicinal product of a fundamentally new class was developed to optimize the treatment of patients with GERD – an esophageal mucosal protectant, which consists of a fixed combination of hyaluronic acid and chondroitin sulfate dissolved in a bioadhesive carrier (polymerase 407). This review is primarily aimed at systematizing data on the efficacy of the esophageal mucosal protectant in the treatment of patients with GERD. The systematic review that summarized the results of 10 studies involving 1090 patients with GERD showed that adding this esophageal mucosal protectant to the PPI therapy increased the efficacy of GERD therapy, as well as improved the frequency of symptomatic, endoscopic and morphological response to the treatment. Such combination therapy contributes to the optimization of the treatment of patients with various disease phenotypes, regress of both esophageal and extraesophageal symptoms, and potentiation of repair of the esophageal mucosa. To increase the efficacy of treatment and improve the prognosis of the disease, this approach should be implemented at the early stages of therapy in real clinical practice.
Modern opportunities to improve the effectiveness of eradication therapy on a clinical case
Authors: Pakhomova I. G.
Published: October 2022

Today, one of the significant and urgent problems of gastroenterology is Helicobacter pylori infection, which is one of the most common causative agents of chronic infections in humans. The problems of its diagnosis, and to a greater extent therapy, continue to be the subject of numerous consensuses and recommendations. The effectiveness of Helicobacter pylori eradication therapy is quite acute, taking into account both the characteristics of the microorganism itself, the growing antibiotic resistance and the decrease in patients’ adherence to therapy. The choice of treatment regimen is determined by a number of regional characteristics, including indicators of H. pylori resistance to clarithromycin and nitroimidazole, as a result of which regional recommendations are being developed in a number of countries. At the same time, the summary data on the resistance of H. pylori to clarithromycin in Russia do not allow us to speak about high rates of this problem. Therefore, clarithromycin can be used in first-line therapy as an effective component of eradication therapy. At the same time, an important measure to improve the effectiveness of H. pylori eradication is to increase the adherence of patients to therapy, which consists in talking with the patient, providing complete information about the disease, its complications, the need to follow all recommendations and taking prescribed drugs, keeping a patient diary, and, if necessary, telephone contact with the patient. In addition, it is possible to influence compliance by increasing it by prescribing a fixed combination of drugs in one package. An example of this approach is the drug combination of omeprazole, clarithromycin and amoxicillin. This article presents a small review of the literature on the reasons for unsuccessful H. pylori eradication, considers possible ways to improve it, and analyzes a clinical case with a discussion of rational pharmacocorrection.