bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploration of the mechanisms of Cyperi Rhizoma in the treatment of endometriosis through GEO datasets, network pharmacology, and molecular docking studies
Authors: Fang Xingyi , Gong Yi , Li Jinjing , Jin Yanbin , Limeng Yongwei , Ma Yanlin , Huang Yuanhua
Published: March 2023

Cyperi rhizoma (CR) has traditionally been used to treat endometriosis (EMS), but its molecular mechanism remains unclear. To address this, we used a multi-faceted approach that included analysis of GEO datasets, network pharmacology, molecular docking and in vitro experiments.CR components and their potential targets were identified using TCMSP and PubChem, while GEO datasets, GeneCards, and DisGeNET were used to retrieve EMS-related targets. Compound-target and protein-protein interaction networks were constructed using Cytoscape and STRING, respectively, and hub genes were identified using CytoHubba. Enrichment analysis and molecular docking were performed, and RT-qPCR and Western blotting were used to assess protein expression levels. According to our research, there are 18 active CR components and 34 possible anti-EMS targets. Network analysis identified quercetin and kaempferol as potential key chemicals and revealed IL6, MMP9, CCL2, CXCL8, ICAM1, L10, VCAM1, IL18, SELE and TIMP1 as central hub genes in the network. GO, KEGG and GSEA analyses showed that ICAM1 and VCAM1 are involved in "positive regulation of cell adhesion", TNF signalling pathway, NF-kappa B signalling pathway and "GO_INFLAMMATORY_RESPONSE". Analysis of the GEO datasets revealed that ICAM1 and VCAM1 were upregulated in endometriosis compared to controls. Molecular docking showed that quercetin and kaempferol have strong binding affinities for these proteins. RT-qPCR and Western blotting analyses showed that CR treatment suppressed ICAM1 and VCAM1 expression, leading to reduced inflammation and adhesion in endometriosis-associated symptoms. Thus, these results provide a novel rationale for the potential of CR in the treatment of EMS.
Influence of radiotherapy on the physical-mechanical properties of different pit and fissure sealants
Authors: Marubayashi Lucas Masaru , Galo Rodrigo , Barbosa Paulla Iáddia Zarpellon , Oliveira Harley Francisco de Oliveira , Tores Carolina Paes , de Queiroz Alexandra Mussolino , Borsatto Maria Cristina
Published: March 2023

Objectives: This study was to evaluate whether ionizing radiation used in the treatment of Head and Neck Cancer interferes with the adhesion of pit and fissure sealants applied to tooth enamel.
Materials and Methods: A total of 105 healthy human teeth were randomly allocated between the control group (non-irradiated teeth) and irradiated groups subdivided into pre-radiotherapy and post-radiotherapy. The teeth were treated using a resin sealant (Fluoroshield®) or a cement of conventional glass ionomer (Ketac Molar Easymix®). The conventional radiotherapy protocol consisted of applying an irradiation dose of 2Gy per day, over a period of 35 days, totaling a cumulative dose of 70Gy. Marginal microleakage test (n=60 teeth) and shear test (n=45 teeth) were performed. Data statistical analysis considered a significance value of 5%.
Results: Both in the shear test and the microleakage test, the resin sealant presented the best results. Also, there was no statistically significant difference in any of the tests between the non-irradiated groups and groups that received radiotherapy.
Conclusions: Thus, radiotherapy does not influence the adhesion of pit and fissure sealants of the different materials used, and the resin sealant presented better performance when compared to the conventional glass ionomer. Clinical relevance: of this study lies in the fact that patients undergoing radiotherapy treatment can undergo preventive treatment with sealants before or after radiotherapy, with resinous materials being the most suitable for this condition.
Transvaginal Posterior Levatorplasty and Perineoplasty for female Primary Stress Urinary Incontinence: 12-month follow-up and technical presentation
Authors: Xu Yansheng , Wei Lan , Liu Meichen , Jia Zhuomin , Li Yilin , Li Fengyong
Published: March 2023

The levator ani (LA) plays key roles in maintaining continence during sudden increase of intraabodominal pressure. To date, there has been no reports on the treatment of female stress urinary incontinence (SUI) by repairing the LA. We aimed to investigate the feasibility of transvaginal posterior levatorplasty combined with perineoplasty (TPLP) for women with primary stress urinary incontinence and demonstrate the surgical technique with step-by-step procedures. A total of 47 patients were prospectively enrolled in this study with a mean age of 43.6 years. Mean operative time was 78.7minites. Median estimated intraoperative blood loss was 80.2 ml. Objective cure and subjective cure rates were 87.2% and 91.5%, respectively. Compared with baseline, scores of quality of life，symptom severity and sexual function improved after surgery. Meanwhile, mobility of the urethra and bladder neck and areas of levator hiatus were decreased after surgery. There was no major adverse event, except mild coitus pain was reported in 15.4% (6/39) patients at the initial several times of intercourse after resuming sexual activity. In conclusions，this study shows that TPLP appears to be an effective surgical method for selected women with primary stress urinary incontinence.
Preserving Derivative Information while Transforming Neuronal Curves
Authors: Athey Thomas , Tward Daniel , Mueller Ulrich , Younes Laurent , Vogelstein Joshua , Miller Michael
Published: March 2023

The international neuroscience community is building the first comprehensive atlases of brain cell types to understand how the brain functions from a higher resolution, and more integrated perspective than ever before. In order to build these atlases, subsets of neurons (e.g. serotonergic neurons, prefrontal cortical neurons etc.) are traced in individual brain samples by placing points along dendrites and axons. Then, the traces are mapped to common coordinate systems by transforming the positions of their points, which neglects how the transformation bends the line segments in between. In this work, we apply the theory of jets to describe how to preserve derivatives of neuron traces up to any order. We provide a framework to compute possible error introduced by standard mapping methods, which involves the Jacobian of the mapping transformation. We show how our first order method improves mapping accuracy in both simulated and real neuron traces, though zeroth order mapping is generally adequate in our real data setting. Our method is freely available in our open-source Python package brainlit.
Novel molecular subtype-based precision therapy improves prognosis for lung adenocarcinoma patients
Authors: Zuo Ling , Zhang Rui , He Shuting , Zhang Qing , Shi Yu , Xu Qiang , Li Feng , Gai Ling
Published: March 2023

Background
Lung adenocarcinoma (LUAD) is a malignancy with a high global incidence and cancer-related mortality rate. Although various clinical trials have improved the prognosis of LUAD patients, the 5-year survival rate is still low. This study aimed to improve the prognosis of LUAD patients through molecular subtype-based precision therapy.
Methods
LUAD RNA sequencing (RNA-seq) data obtained from online database was used to screen for differentially expressed genes (DEGs). Weighted gene co-expression network analysis (WGCNA) combined with univariate and multifactorial COX analysis was used to identify hub prognostic genes. Based on these genes, pam clustering classified LUAD into two subtypes. The ESTIMATE, Immunophenoscore (IPS), and Microenvironment Cell Populations-counter (MCP-counter) algorithm were applied to determine the microenvironmental purity and immune response of the two subtypes. Genomic enrichment analysis (GSEA) was performed to analyze the function. Mutational difference was also explored. The effects of cisplatin and FASNi on gene expression were examined by RT-PCR.
Results
The results showed that LUAD patients could be divided into two subtypes. The survival rate of patients in cluster 2 was signifcantly higher than that in cluster 1 (P = 7.9e-3). Patients in cluster 2 had more immune cell infiltration, higher microenvironmental component, and higher rate of EGFR mutations (P < 0.05). In contrast, patients in cluster 1 had more fibroblast infiltration and high rate of NTRK3 mutations (P < 0.05). In addition, functional analysis suggested cluster 1 was associated with Nucleotide sequence repair, while cluster 2 mainly related to lipid metabolism and angiogenic pathways (FDR < 0.25). RT-PCR indicated that cluster1-related model genes were associated with cisplatin, cluster2-related genes were associated with EGFR-targeted therapy and lipid metabolism inhibitors.
Conclusions
This study showed patients in cluster 1 may benefit from anti-Nucleotide repair therapies such as platinum, radiotherapy, targeting fibroblasts, and targeting NTRK3, while patients in cluster 2 benefit from immunotherapy, anti-angiogenic, targeting lipid metabolism, and targeting EGFR therapy. This study may provide new insights to improve the overall prognosis of LUAD patients through molecular subtype-based precision therapy.
Association of Obstructive Sleep Apnea and Diurnal Variation of Cystatin C
Authors: Lee Seolhyun , Noh Sungryong , Lee Woo Hyun
Published: March 2023

Purpose
Obstructive sleep apnea is a known risk factor for the progression of chronic kidney disease. To find early signs of the progression in subjects with obstructive sleep apnea., we assessed the diurnal variation of kidney biomarkers.
Methods
A prospective observational study was conducted at Kangwon National University Hospital, Chuncheon, South Korea. All participants underwent in-laboratory polysomnography and phlebotomy in the evening before the polysomnography and in the morning after the polysomnography. Kidney biomarkers, including serum creatinine, blood urea nitrogen, and serum cystatin C, were measured. Delta kidney biomarkers were calculated by subtracting the evening level of the biomarkers from the morning level.
Results
Twenty-six of 50 participants had severe obstructive sleep apnea. Delta cystatin C was significantly correlated with apnea-hypopnea index, oxygen desaturation index, and total arousal index with coefficients of -0.314, -0.323, and − 0.289, respectively. In participants without severe obstructive sleep apnea, the morning cystatin C level (0.84 ± 0.11 mg/L) was significantly higher than the evening cystatin C level (0.81 ± 0.11 mg/L) (P = 0.005). With severe obstructive sleep apnea, the cystatin C levels were not different between the morning (0.85 ± 0.11 mg/L) and the evening (0.85 ± 0.10 mg/L).
Conclusions
Morning Cystatin C level was significantly increased only in participants without severe obstructive sleep apnea, presumed due to nocturnal decline in glomerular filtration rate. The absence of the nocturnal decline in glomerular filtration rate with severe obstructive apnea may be an early sign of kidney damage.
Posterior spinal fusion for severe kyphosis in a child with Gaucher disease: a case report and review of the literature
Authors: Zhao Tengfei , Zhang Ning , Chen Linwei , Wang Yifan , Li Jun , Chen Qixin , Li Fangcai
Published: March 2023

Background The skeleton involvement is one of the most significant aspects of Gaucher disease (GD).However, the treatment for spinal involvement in GD among patients undergoing enzyme replacement therapy (ERT) is poorly characterized. We present a case of progressive kyphotic spinal deformity in a young child caused by vertebral involvement, which was managed by posterior spinal fusion without anterior spinal release under ERT.
Case presentation A 10-year-old boy presented progression kyphosis ( thoracic kyphotic angle of 113°) associated with type IIIb GD had undergoneposterior spinal fusion with segmental pedicle screw fixation (from T6-L3) and Ponte osteotomy. The patient went back to school without further brace protection. Proximal junctional kyphosis (PJK) was observed at 4 months postoperatively. Revision surgery was performed to prevent the neurological impairment. Additional posterior spinal fusion from T2–T6 and decompressive laminectomy was performed during the revision surgery. 2-year of follow-up showed no recurrence of PJK and solid fusion was achieved in the patient under ERT and brace protection.
Conclusions Posterior spinal fusion without anterior spinal release is a good treatment option for severe spinal deformity in patients with GD. However, the fusion level and reinforced fixation require careful consideration, revision surgeryand brace protection is needed as long as PJK was observed.
Twelve-month Outcomes of a Mental Illness Destigmatizing Theatrical Intervention in Rural Uganda
Authors: Lee Yang Jae , Christ Ryan , Blackwell Scott , Rauben Kazungu , Krause Alyssa , Monnig Emery , Ssekalo Ibrahim , Iheanacho Theddeus , Rosenheck Robert
Published: March 2023

Purpose Evaluate the long-term effectiveness of a community-led theatrical intervention in reducing mental health stigma in a low-income setting in Uganda. Methods A follow-up survey of study participants was conducted 12 months after the initial community-led theatrical intervention measuring the primary outcomes of mental illness stigma using the Broad Acceptance Scale (BAS) and the Personal Acceptance Scale (PAS). Results Of the initial 57 participants, 46 (80%) completed the follow-up survey. The average improvement in Broad Acceptance Scale and Personal Acceptance Score observed from baseline to twelve months after the intervention was 1.435 (95% CI: 0.826–2.044, p < 0.0001, SD: 1.64) and 2.152 (95% CI: 1.444–2.860, p < 0.0001, SD: 1.93), respectively. Both effect sizes were within the confidence intervals of the average improvement observed one week after the intervention. Conclusion Exposure to the community-led theatrical intervention continued to confer a significant and substantial reduction in mental illness stigma.
Challenges of the forage crops in northwestern Ethiopia
Authors: DESTA ALEMU GASHE
Published: March 2023

Inadequate quality and quantity of animal feed are major factors influencing livestock production in Ethiopia. The primary feed sources (crop residue and natural pasture) were insufficient to meet even the annual maintenance requirement for livestock feed. To address this disparity, the production of cultivated forage is essential. Identifying the constraints and opportunities for improved forage production is critical for developing forage crops and intervention options for forage and livestock production. However, due to various constraints, the production and utilization of forage crops for animal feed are low in Ethiopia's highlands. Therefore, the purpose of this study was to identify the types, strategies, and constraints of forage crop production in three agroecologies (high, mid, and lowland agroecologies) of the east Gojjam zone. Two districts were chosen at random from all agroecologies. A total of 12 peasant associations from six districts (two from each district) were chosen using a simple random sampling system. A total of 360 respondents were taken from all agroecologies using a simple random sampling system. The data was collected through focus group discussions and individual interviews, and it was analyzed using SPSS. According to the findings, only 51% of respondents developed forage crops, due mainly to factors such as land scarcity (60.4%), a lack of awareness (24.0%), a lack of seed (14.6%), a lack of water (8.3%), and a fear of farmers birds setting on forage (3.1%). Chamaecytisus palmensis (tree lucerne) was the only forage in the highland agroecologies, whereas Sesbania sesban was the dominant species in the midland agroecologies. The dominant improved forage development strategy in all agroecologies was backyard, which did not compete with food crop production.
A new method to predict refracture risk after locking compression plate removal of clavicle shaft
Authors: Han Shuai , Wang Qinghe , Tan Fang , Bai Yunpeng , Li Kun , Qiu Yongmin , Ding Juhong , Li Shuang , Wang Jian
Published: March 2023

Aims:
The incidence rate of subsequent refracture after removal of the implant in mid-shaft clavicle fracture patients is relatively high. This can lead to additional medical costs and cause doctor-patient dispute. This study tries to introduce a new method to predict the refracture risk of the clavicle after hardware removal.
Methods:
A retrospectively review of 244 patients who had undergone ORIF with LCP for mid-shaft clavicle fractures, and had hardware removal surgery after bony union from January 2013 to September 2022 at our hospital was performed. We evaluated basic demographic characteristics, and analyzed the mean gray value of screw holes with the Image J software, which was extensively used in Western-blot analysis.
Results:
Our study showed that about 2.0% patients suffered refracture after removal of the LCP. For the first time we found obvious differences in remaining bone ratio and the index of remaining Clavicle intensity between the two groups. There was no difference between groups with regards to preoperative characteristics.
Conclusions:
Surgeons should mention that there is a relatively higher possibility of refracture rate and emphasize a proper immobilization after secondary operation. There are no significant preoperative demographics parameters associated with refracture. The mean gray value of screw holes on immediate postoperative X-ray can be a potential clinical predictor for refracture rate after LCP removal.
Exogenous [Pyr 1 ]apelin-13 prevents bupivacaine-induced cardiotoxicity via the receptor APJ
Authors: Chen Chaoxing , Zhao Shishi , Chen Zhengjie , He Yuting , Chen Jiali , Zheng Liangyu , Xia Yun , Papadimos Thomas J. , Shi Kejian , Chen Hongfei , Liu Le , Xu Xuzhong , Jin Zhousheng , Wang Quanguang
Published: March 2023

Backgrounds
Abnormal energy metabolism is an important mechanism in bupivacaine-induced cardiotoxicity. Apelin, an adipocyte-derived peptide involved in energy metabolism and regulation of the cardiovascular system, may be linked to bupivacaine-induced cardiotoxicity. Here we investigated the role of apelin in bupivacaine-induced cardiotoxicity and its relationship with energy metabolism.
Methods
We used both an ex vivo Sprague-Dawley (SD) neonatal rat cardiomyocyte toxicity model and an in vivo bupivacaine-induced rat asystole model to investigate the effect and mechanism of exogenous [Pyr1]apelin-13 in bupivacaine-induced cardiotoxicity.
Results
Exogenous [Pyr1]apelin-13 (22 μM) prevented bupivacaine-induced (90 μM) inhibition of the cardiomyocyte beating frequency (mean difference: 0.48, 95% CI: 0.35 to 0.62 versus C-bupi, p<0.001, n=5) in cells treated with bupivacaine for 60 minutes, preserved the mitochondrial ultrastructure and regulated the oxygen consumption rate , and these effects were inhibited by APJ shRNA. Exogenous [Pyr1]apelin-13 (150 μg·kg-1) increased the survival rate of SD rats with bupivacaine-induced (30 mg·kg-1) asystole (12/12 (100%) versus 6/12 (50%), p=0.014), while F13A (150 μg·kg-1), an APJ antagonist, abolished this response (3/12 (25%)). Apelin also increased the expression of adenosine monophosphate-activated protein kinase, acetyl Co-A carboxylase, and peroxisome proliferator-activated receptor-gamma coactivator-1α in SD rats heart tissue.
Conclusion
Exogenous [Pyr1]apelin-13 prevented bupivacaine-induced cardiotoxicity via the receptor APJ in adult male SD rats and SD neonatal rat cardiomyocytes through the preservation of mitochondrial structure and function.
A delayed deep reservoir computer for dynamical modelling
Authors: Liu Jianming , Xu Xu , Li Eric
Published: March 2023

Reservoir computing is an effective machine learning paradigm. We propose a new reservoir computing called delayed deep reservoir computer (DDRC), DDRC is based on feedforward neural networks (FNNs), the input of the current time and delayed time are projected into the high-dimensional space by FNNs in parallel, and are combined into a high-dimensional feature representation through a set of weight coefficients. Feature representation vectors are mapped to the output by linear regression. DDRC retains the advantages of simple training and small computation of ESN, only readout weight requires learning from the data. Several numerical experiments show that DDRC achieves better results in chaotic time series prediction. In particular, DDRC enables long term prediction of multiple superimposed oscillator (MSO) sequence.
Pancreas Segmentation in CT based on RC-3DUNet with SOM
Authors: Liu Zhe , Ma Siqi , Liu Yi , Wang Wenqiang , Song Yuqing , Su Jun , Tang Yangyang , Yu Aihong , Liu Xuesheng
Published: March 2023

Automatic and accurate 3D pancreas segmentation based on deep learning, playing an important role in medical professional's diagnosis and treatment of diseases, has received a lot of attention from medical image processing community. Although sufficient works on 3D pancreas segmentation have been conducted in recent years, they embrace two shortcomings: one is that the server environment required for segmentation is too excellent and not friendly to the public, and the other is that the segmentation accuracy needs to be further improved. In response to the above problems, we propose a Selecting the Overlap Method (SOM) operation that effectively relieves the memory pressure and associates contextual information. To accurately segment 3D medical images, a 3D segmentation model called RC-3DUnet is designed to reduce the parameters during segmentation compared with the general network. This integrates our newly proposed coarse-to-fine segmentation method, which utilizes SOM and RC-3DUnet, to both reduce the running memory environment required for 3D segmentation of the pancreas and increase the accuracy rate. Extensive experiments were conducted on the Medical Segmentation Decathlon (MSD) pancreas segmentation and the National Institutes of Health (NIH) pancreas segmentation datasets, showing our results not only showed higher accuracy than other excellent methods but also demonstrated that our method is more lightweight.
Aerobic and anaerobic potential microbial consumption of salt marsh soils organic matter
Authors: Piñeiro-Juncal Nerea , Cortizas Antonio Martinez , Sousa Ana I.
Published: March 2023

Salt marshes have a high capacity to stabilize organic carbon in their soils as organic matter (OM). Globally, they are estimated to hold ~862 to 1,350 Tg of organic carbon in the upper meter. Which OM compounds are accumulated and which are the mechanisms protecting them, beyond anoxia, are important questions to unravel and understand the full potential of salt marsh ecosystems to store carbon. Soil microbial communities have a key role in OM degradation and, therefore, in its accumulation. In this study, performed at Ria de Aveiro (Portugal) coastal lagoon, two techniques were successfully applied to explore OM microbial mineralization in salt marsh soils: EcoPlatesTM under aerobic and anaerobic conditions, and Fourier-transform infrared spectroscopy (FTIR), together with principal component analysis on the transposed matrix, to extract the signal of specific compounds. The soil samples showed a high spatial homogeneity in microbial potential consumption, regarding both depth (up to 89 cm) and halophyte species. Potential aerobic consumption was high at all depths but the anaerobic communities showed a higher diversity in carbon sources consumption. Amino acids, carbohydrates and polymers were widely consumed, while half of the carboxylic acids were not consumed. Two of the carbon sources that were not consumed were likely protected within bigger molecules, D-galacturonic acids within hemicellulose and 4-hydroxy benzoic acids within phenolic compounds, being the last most likely accumulated as blue carbon. In addition, our study shows the potential of microbial incubations coupled with FTIR to greatly increase our understanding of salt marsh soils OM dynamics.
Anterior acetabular sector angle is a potential indicator for identifying subchondral fatigue fracture of the femoral head in young military recruits
Authors: Yang Junzheng , Chen Peng , Chen Baihao , Zhao Bin
Published: March 2023

Purpose
This study aimed to evaluate the intrinsic risk factors for SFFFH in young military recruits.
Methods
We retrospectively analyzed 98 SFFFH and 24 ONFH patients who were affiliated with the Chinese People's Liberation Army (PLA) between 2013 and 2019. X-ray and MRI were the main data for analysis. Acetabular anteversion of the superior acetabulum (AVsup), acetabular anteversion of the center of the acetabulum (AVcen), anterior acetabular sector angle (AASA), posterior acetabular sector angle (PASA), superior acetabular sector angle (SASA), neck-shaft angle (NSA), inferior iliac angle (IIA) and ischiopubic angle (IPA) were calculated by two observers with three times. Then, logistics regression and independent samples T-test were performed to analyze the above data to explore the risk factors of SFFFH.
Results
Based on the results of logistics regression, age (OR: 1.33; 95% CI: 1.12-1.65; P-value = 0.0031) could be considered as the indicator. AVcen (P-value = 0.0334), AASA (P-value = 0.0002), NSA (P-value = 0.0007), IIA (P-value = 0.0316) were considered to be statistical significance. Further, AVcen (OR: 1.41; 95% CI: 1.04-1.95) and AASA (OR: 1.44; 95% CI: 1.21-1.77) especially AASA (area under curve: 66.6%) should be paid much more attention.
Conclusions
We unveiled that AASA could be the key factor for SFFFH, which further verified that deficient anterior coverage of the acetabulum might be the main cause of SFFFH.
Modelling Clean Energy Transition Pathways for India’s Power Sector Using OSeMOSYS (Open-Source Energy Modelling System)
Authors: Lobo Fern , Hannah  , Yeganyan Rudolf , Canonne Carla , Tan Naomi , Jansen Malte , Howells Mark , Patterson Simon
Published: March 2023

India, an economic powerhouse with a rapidly increasing population and considerable global influence, is uniquely positioned to shape how developing nations achieve a clean energy transition. With ambitious targets set at COP-26, a clear route to achieving this must be established. Specifically, India faces the critical challenge of shifting away from coal and increasing its share of renewable energy. Of the five targets set at COP-26, this study has focussed on: 1) Reaching 500 GW Non-fossil energy capacity by 2030 (focussed on exceeding this target by 50GW) 2) Reducing total projected carbon emissions by one billion tonnes, and 3) Achieving net zero by 2070. However, considering India’s social and economic dependency on the coal industry, along with the immense pressure from the significant, growing population, how these targets can be achieved must be scrutinised to form a clear roadmap for success. Energy System Modelling (ESM), specifically OSeMOSYS, have provided a valuable mechanism for formulating evidence-based policy recommendations. This study developed a “starter data kit” for India, allowing for the modelling of six scenarios based on the three aforementioned COP-26 targets. The modelled scenarios are as follows: a Low Cost (LC) scenario; a Fossil Future (FF) scenario, where no new investment is made in renewable energy or efficiency after 2021; a scenario where 550GW of solar/wind/hydropower is integrated into the system by 2030 (RE); Net Zero by 2070 (NZ); Net Zero by 2070, with 550 GW of renewables and a 1 billion tonne reduction in carbon emissions (NZ + RE - Emissions); and a scenario with 550 GW of renewables combined with the 1 billion tonne CO2 reduction (RE - Emissions). The results of this modelling, along with a comprehensive literature review, found that to achieve all three targets a shift in baseload energy is required, suggesting nuclear and biomass as suitable sources. Despite the high capital cost of nuclear, its longevity and low running costs counter this. It was also determined that securing 550 GW of renewable energy by 2030 is an important starting point for renewable energy penetration. However, increased system dependence on renewables requires a congruent scale-up of energy storage capabilities to address system instability, specifically to ~160 GWh of capacity. Finally, deep penetration of energy efficiency (EE) is integral to success, which should be promoted with improved fiscal and financial incentives, along with education campaigns. To achieve its COP-26 climate targets, India should consider the implementation of the above recommendations.
A Systematic Review on the Extant of Tanzania e-Government Services for Economic Development
Authors: Mwilongo Kardo , Kachota Beth
Published: March 2023

The current paper investigates the extant of Tanzania e-government services for economic development by focusing at the recent literature through systematic review of literature. The main objective is to look at how researchers are studying e-government services toward achieving the Tanzania national development goals and economic growth, what are the current issues investigated and what is going to be the direction of the topic globally. The findings reveal that the Tanzania e-government services are performed at the ministerial, departmental, agencies and institutions through various information systems including the webpages and social networks. Various levels of e-government implementation and performance are being deployed for public services and economic development. However, a number of factors related to infrastructures, technology, human capital, policy, practitioners and partnerships among others were identified to hinder the delivery of e-government services to the public and brought adverse effect on e-government performance for economic development.
Timings of treatments determine the effectiveness of insecticides in controlling the cotton pink bollworm, Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae)
Authors: Busnoor Abhishek V , Wadaskar RM , Fand Babasaheb B , Tambe VJ , Pillai T , Mahule DJ , Nagrare VS , Prasad YG
Published: March 2023

The cryptic nature enabled reduced vulnerability to insecticidal control of the pink bollworm Pectinophora gossypiella (Saunders), a serious threat to transgenic cotton cultivation due to development of resistance against Bacillus thuringiensis (Bt) toxins necessitated determining the critical timings of spray applications on the effectiveness of its control. This study assessed the influence of egg age and location of larvae as exposed vs. burrowed inside the bolls on insecticide control efficacy.
The results revealed significant decrease in ovicidal activity of test insecticides with the increase in age of eggs from one day old to three days old (paired t-test, P values <0.05). The larvae directly exposed to the insecticide residues on boll rind were more susceptible (>80% mortality) than that of larvae exposed after they burrowed inside the bolls (<49% mortality). The inhibitory effects of test insecticides on the developmental biology were more pronounced in the experiment on pre-larval release insecticide treatment compared to insecticide treatment given post-larval release and entry inside the bolls. Very low fecundity (< 5 eggs/female), higher effective deterrency (>96%) and higher avoidance index (>0.93) revealed oviposition deterrent activity of test insecticides. The test insecticides also exhibited significant adulticide action on PBW moths. The study has generated information crucial to the development of effective management strategy for cotton pink bollworm.
Coherent forward scattering as a robust probe of multifractality in critical disordered media
Authors: Martinez Maxime , Lemarié Gabriel , Georgeot Bertrand , Miniatura Christian , Giraud Olivier
Published: March 2023

We study coherent forward scattering (CFS) in critical disordered systems, whose eigenstates are multifractals. We give general and simple arguments that make it possible to fully characterize the dynamics of the shape and height of the CFS peak. We show that the dynamics is governed by multifractal dimensions D_1D1 and D_2D2, which suggests that CFS could be used as an experimental probe for quantum multifractality. Our predictions are universal and numerically verified in three paradigmatic models of quantum multifractality: Power-law Random Banded Matrices (PRBM), the Ruijsenaars-Schneider ensembles (RS), and the three-dimensional kicked-rotor (3DKR). In the strong multifractal regime, we show analytically that these universal predictions exactly coincide with results from standard perturbation theory applied to the PRBM and RS models.
Knowledge and Practices of Female Traditional Healthcare Givers to Mothers on Referral System for Care and Immunization against Childhood Killer Diseases in Hard-to-Reach Areas of Adamawa State - Nigeria
Authors: Relester Takwi,
Published: March 2023

Female Traditional Healthcare Givers’ (FTHGs) knowledge, attitude, and practice on maternal and infant survival from pregnancy, delivery, and after birth has been a contextual matter throughout the globe, especially where the incidence of infant mortality rate is high. This often poses questions as to why, what happened, and where women of childbearing go for health seeking when pregnant, at birth, and after delivery? The impact of FTHGs activities to mothers and infants on their education and referral of mothers and children for treatment and immunization was studied in the three Senatorial Districts of Adamawa State. Self-structured questionnaires with both open and closed-ended responses and oral interviews were used for the purpose of the study and analyzed electronically on SPSS version 25.0. Approaches to improve the knowledge and practice of Female Traditional Healthcare Givers include seminars and workshops by Non-Governmental Organizations’, Antenatal Care at government health facilities, and health professionals’ effort in-home visits and formal education. These have improved FTHGs knowledge, skills, and acceptance of immunization programme against childhood killer diseases in most of the Senatorial District communities. Maternal and infant morbidity and mortality has experienced a great reduction in the process as FTHGs made referrals to health facilities on cases needing treatment and immunization. This underlies the need for training in epidemiological findings to prevent the incidence of infant morbidity and mortality since education is the key to a healthy live. Keywords: Childhood killer diseases, Epidemiological, Female Traditional Health care Givers, Healthcare, Immunization, Infant morbidity, Mortality, and Referral.
Metaorganizações na Formatação de Mercados: Proposições Teóricas
Authors: Acosta Daniela Caldas , Vieira Francisco Giovanni David
Published: March 2023

Este ensaio teórico apresenta proposições teóricas de que a metaorganização (MO) atua na formatação de mercados performando uma tripla agência entre o meio econômico (mercado), o meio social e o meio político. O estudo toma como ponto de partida concepções e pressupostos alicerçados na Sociologia dos Mercados e na Teoria Ator-Rede, tendo como referência fundamental o caráter performático dos atores que atuam nos mercados. Assume-se o pressuposto de que Marketing, enquanto área de atuação e campo de conhecimento, é performativo por meio da constituição e exercício de suas práticas. Tais práticas podem ser delineadas na atuação das MOs, consideradas atores de mercado, mas que atuam como uma organização coletiva de entidades ou uma associação de organizações. As ações das MOs vêm destacando-se a partir da globalização e em diferentes frentes, em especial nos meios social, econômico e político. O entendimento teórico desenvolvido no ensaio objetivou um mapeamento de teorias que explicam o mercado na perspectiva dos Estudos de Mercado Construtivistas (EMC), que possibilitam um maior entendimento e aproximação com os conhecimentos da disciplina de marketing. Tendo como base tais pressupostos, bem como discussões acerca do desempenho das associações empresariais na construção e formatação do mercado, as proposições destacam que a MO age numa ação coletiva na construção do mercado, e, sendo assim, foi possível considerar que podem performar mercados preferencialmente por práticas representacionais e normativas.
Formation of Market Foundations of Health Care Organization in Ukraine (Commercial Legal Aspect)
Authors: Zadykhaylo Dmitry , Savchenko Anna
Published: March 2023

In the article were analyzed the state and prospects of further medical reform in Ukraine. The authors set themselves the goal of conducting a study of the essence of health care reform, and during this process advantages and disadvantages of implemented changes in this area were characterized. The importance of this study lies in the fact that human health and life are recognized at the constitutional level as the highest price, and therefore their protection requires special attention from the state. Promoting the development of health care system improve the quality of life of the population, which in the future will have a positive effect on the economic development of the country. Four main directions of the reform were developed in the work, such as improving the quality of medical services, optimizing the financing of the health care system, improving the management system, and changes in the pharmaceutical sector. An important achievement of the reform is the introduction of the medical services market, which has its own specific features and base on the principle of free competition and financial transparency. The article focuses on the legal regulation of public relations in the field of health care. Legislative provision of this is considered from the point of view of creating a competitive market for medical services, which is opposed to the administrative model of ensuring citizens' health care. The institutional nature of the organization of such market with relevant entities providing services competing with each other is emphasized; medical service in its commodity-value aspect; introduction of the principle of consumer choice of medical service and the entity that provides it; creation of a special state agency that pays the cost of the provided medical service to the relevant subject of medical activity for the benefit of the beneficiary-consumer, who chose this particular subject. Accordingly, the driving force of the market is recognized  the actual medical economic activity. Taking into account the above, the article, based on the analysis of the relevant legal acts, concludes that relations in the field of health care have been transformed in the direction of the economic and legal nature of their regulation. This is evidenced by the use of stable constructions of economic law, namely: economic activity; non-commercial management; communal non-commercial enterprise; state regulation of economic activity; subject of organizational and economic powers, etc. The continuation of scientific researches on this issue will contribute to the further development of the national health sector, including by improving the public management of this component of the national economy.
Features of Taxation of Income Received from Performing an Independent Professional Activity in the War Period
Authors: Pоstoronko Yevhen
Published: March 2023

The article analyzes the changes in income taxation of self-employed persons due to the introduction of martial law. A comparison of the transformation in taxation of two types of self-employed persons, namely: individual entrepreneurs (who are on a simplified taxation system) and persons who conduct independent professional activities. The purpose of this article is to consider and analyze the features of taxation of income from independent professional activities during the wartime period. It has been established that the legislation provides for changes in the norms regarding terms, tax control, liability (penal sanctions), exemption from taxation, reduction of tax rates, etc. for various categories of taxpayers. It was found that there is no uniform approach to the taxation of incomes of such categories of taxpayers as natural persons-entrepreneurs and persons engaged in independent professional activity, which indicates a violation of the principles of equality, social justice, legality and a unified approach to the establishment of taxes and fees, contributes to the imbalance in the implementation of economic tax principles, formation of burdensome tax burden. The legislator did not create favorable conditions for taxing the income of persons engaged in independent professional activity. At the same time, the Tax Code of Ukraine stipulates that mobilized persons who carry out independent professional activities, who had or did not have hired workers, were called up for military service during mobilization or were involved in the performance of responsibilities for mobilization in positions provided for by wartime states, for the entire period of their military service are exempted from the obligation to calculate, pay and submit tax reports on personal income tax and military levy. Under such conditions, such persons, on behalf of their employees and for the duration of their military service under conscription during mobilization, authorize another person to pay wages and/or other income to employees, then the obligation to calculate and withhold personal income tax and military collection from such payments for the period of military service. But we must not forget that this norm existed even before the full-scale invasion. It was concluded that the legal regime of martial law and its legal consequences made adjustments to the legal regulation of taxation of income from independent professional activity. However, there is currently a discriminatory regulation of income taxation of persons engaged in independent professional activity. This indicates the need for the legislator to create favorable conditions for taxation of income from independent professional activity.
Quantitative analysis on the oil content of oilfield wastewater based on a convolutional neural network model and ultraviolet transmission spectroscopy
Authors: Wang Qiushi , Li Haolin , Zhao Haiqian , Zhang Xiaoxue , Arıcı Müslüm , Li Huaizhi
Published: March 2023

Oil content (OC) is one of the important evaluation indicators in oilfield wastewater (OW) treatment. The purpose of this study is to realize online real-time detection of OC in OW by combining ultraviolet spectrophotometry with the convolutional neural network (CNN). In this paper, 80 groups of OW transmission data were measured for model establishment. Three CNN models with different structures are established to generalize the super parametric optimization process of the model. Furthermore, as a common method used in spectroscopy, the synergy interval partial least squares (siPLS) model is built in order to compare its accuracy with the CNN model. The results indicated the CNN model has a better performance than siPLS, in which the CNN model numbered Model 3 has the lowest root mean square error (MSE) of prediction (RMSEP) of 1.606 mg/L. As a consequence, the CNN model can be used in the monitoring of OW. This article will guide a rapid analysis of the OC of OW.
El Cine: una alternativa educativa en la cultura de paz desde la escuela
Authors: Peña-Murcia Deysi , Vargas-Montañez Nelson , Fuentes-Mejía Cristina
Published: March 2023

En educación se presenta una amplia reflexión frente a estrategias didácticas que posibiliten procesos de enseñanza-aprendizaje en el aula; lo que resulta crucial frente a discursos en la educación colombiana como lo es la ´cultura de paz´, un tema complejo. Por tanto, el cine se presenta como alternativa que permite construir un ambiente para el aprendizaje y la enseñanza. Por estas razones se realizó una reflexión con base en literatura que aborda al constructo de paz y su relación con los discursos de ´enseñanza para la cultura de paz´, así como la idea del cine como alternativa educativa. Para el desarrollo metodológico con el fin de presentar una reflexión argumentada fue realizada una búsqueda de material bibliográfico, especialmente artículos publicados que abordaran investigaciones relacionadas con: ´paz´, ´cultura de paz´, ´cine y educación´. Como resultado se pudo inferir que a partir de la lectura y análisis de los documentos hallados se logró argumentar la idea del cine como una valiosa herramienta pedagógica que moviliza procesos de enseñanza-aprendizaje favorables en el aula, por lo tanto, el cine es un recurso que posibilita la enseñanza y el fomento de la construcción de cultura de paz.
Traditional Chinese Medicine as the Preventive and Therapeutic
Remedy for COVID-19
Authors: Gasmi Amin , Tippairote Torsak , Mujawdiya Pavan Kumar , Menzel Alain , Lysiuk Roman , Shanaida Mariia , Lenchyk Larysa , Peana Massimiliano , Bjørklund Geir
Published: March 2023

The coronavirus disease 2019 (COVID-19) pandemic still has tremendous impacts
on the global socio-economy and quality of living. The traditional Chinese
Medicines (TCM) approach showed encouraging results during previous outbreaks of Severe
Acute Respiratory Syndrome-related Coronavirus (SARS-CoV) and the Middle East
Respiratory Syndrome Coronavirus (MERS-CoV). With limited treatment availability,
TCM herbs and formulations could be useful to reduce COVID-19 symptoms and potential
sources for discovering novel therapeutic targets. We reviewed 12 TCM herbs and
formulations recommended for COVID-19 management by the National Health Commission
and as National Administration of Traditional Chinese Medicine of the People's Republic
of China. This article explored the Chinese national authorities' guidelines from
2003 to 2020, the scientific data in public databases for the recommended TCM remedies,
and their potential mechanistic actions in COVID-19 management. Several TCM
herbs and formulations could potentially benefit COVID-19 management. The recommended
TCM oral preparations list includes Huoxiang zhengqi, Jinhua Qinggan, Lianhua
Qingwen, and Shufeng jiedu; the recommended injection preparations comprise
Xiyanping Xuebijing, Re-Du-Ning, Tanreqing, Xingnaojing, Shenfu, Shengmai, and Shenmai.
TCM remedies are viable options for symptom alleviation and management of
COVID-19. The current SARS-CoV-2 pandemic presents an opportunity to find novel
therapeutic targets from TCM-active ingredients. Despite the recommendations in Chinese
National guidelines, these remedies warrant further assessments in well-designed
clinical trials to ascertain their efficacy in the treatment of COVID-19.