bluuebunny/crossref_metadata_2025 huggingface dataset:
PLANE METRICS AND THE UNIFORMIZATION THEOREM ON MINIMAL THE THREE DIMENSIONAL SPHERE
Authors: Montaño Oscar , Perdomo Oscar , Salas Nazly
Published: November 2023

Let (M, g) be a torus with a riemannian metric g. The Uniformization theorem implies the existence of a covering conforma! map <:p : R2 ----> /1.1 such that the group H,t, of diffeo­morphisms p: R2 ---+ R2 such that <Pop= <j,, is a subgroup of the group of translations in R2 and is isomorph to Z2• The classical proof of his theorem uses tools from algebraic topology and PDE's in Sobolev spaces. In this paper we will give an alternative and easier proof of this theorem in the case that M is a minimal immersed torus in the unit three dimensional sphere, S3. We will achieve this theorem by studying the shape operator of minimal torus on the sphere. One of the main ideas of the this paper is to induce the reader to the study of minimal torus in S3• Recall that one important conjecture in differential geometry is Law­son's conjecture. This conjecture states that the only minimal embedded tori in S3 are the Clifford tori.
CARACTERIZACIÓN DEL AGENTE CAUSANTE DE LA ANTRACNOSIS EN TOMATE DE ÁRBOL, MANZANO Y MORA
Authors: Saldarriaga-Cardona Alegría , Castaño-Zapata Jairo , Arango-Isaza Rafael
Published: November 2023

La Antracnosis es una enfermedad que en Colombia causa pérdidas superiores al 50% en tomate de árbol, manzano y mora. Se ha reportado al hongo Colletotrichum gloeosporioides como el agente causal de la enfermedad; su manejo se basa fundamentalmente en la aplicación de fungicidas, con resultados poco satisfactorios, lo que motivó la realización de estudios de la verdadera etiología de la enfermedad. La caracterización morfológica del hongo se complementó mediante pruebas moleculares usando oligonucleótidos específicos, dando como resultado que C. acutatum es el agente causal de la enfermedad, permitiendo además diferenciar a C. gloesoporioides de C. acutatum.
Single-electronic Multi-level Adders
Authors: Melnyk Oleksandr , Kravets Maksym , Kravets Valerii
Published: November 2023

Since metal-oxide-semiconductor microelectronic structures have reached small-scale and quantum limitations, technological models of single-electron nanocircuits of multi-level adders have been created in the work. It has been proven that one bit of information can be encoded by the presence or absence of one electron on a quantum island cluster.This paper provides a simulation of a 4×4 multiplier circuit on the proposed one-bit full adder. As a result, a comparison with other adders was made, an analysis of energy dissipation depending on temperature and the dissipated power of the existing and proposed multipliers in nW was carried out. As a result, it was found that the proposed adder has better properties compared to similar ones. As a result of the work, the simulation of the 4×4 multiplier circuit was performed, and the simulation results were obtained. Modeling of the circuit was performed in QCAD DESIGNER software.
Chrysophanol ameliorates oxidative stress and pyroptosis in mice with diabetic nephropathy through the Kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2 signaling pathway
Authors: Yuan Xinzhu , Tang Wenwu , Lin Changwei , He Hongni , Li Lingqin
Published: November 2023

Diabetic nephropathy (DN), a microvascular complication of diabetes, increases the risk of all-cause diabetes and cardiovascular mortalities. Moreover, oxidative stress and pyroptosis play important roles in the pathogenesis of DN. Rhubarb is widely used in traditional medicine, and chrysophanol (Chr), a free anthraquinone compound abundant in rhubarb, exhibits potent antioxidant properties and ameliorates renal fibrosis. Therefore, this study aimed to investigate the effects of Chr on renal injury, oxidative stress, and pyroptosis in mice with DN. A DN model was established by feeding the mice a high-sugar and fat diet and injecting them with 50 mg/kg streptozotocin as a positive control. The DN mice had significantly impaired renal function, thickened glomerular thylakoids and basement membranes, increased fibrous tissue, and inflammatory cell infiltration. Superoxide dismutase (SOD) levels were reduced, malondialdehyde (MDA) levels were increased, interleukin (IL)-1β and IL-18 increased, and cleaved caspase-1, caspase-1, and gasdermin D (GSDMD) involved in the process of pyroptosis were upregulated in DN. Kelch-like ECH-associated protein 1 (Keap1) expression was upregulated, and nuclear factor erythroid 2-related factor 2 (Nrf2) expression was downregulated. Compared to those in the DN group, the Chr-treated mice with DN had improved renal dysfunction, weakened glomerular thylakoid and basement membrane thickening, and reduced fibrous tissue proliferation and inflammatory cell infiltration. Additionally, Chr increased SOD levels, decreased MDA, IL-1β, and IL-18, down-regulated caspase-1, cleaved caspase-1, GSDMD, and Keap1 expression, and upregulated Nrf2 expression, which reversed the DN. Therefore, Chr reduced oxidative stress and pyroptosis in DNmice by activating the Keap1/Nrf2 pathway.
The Effect of Motivational Psychotherapy on Academic Motivation in Students
Authors: Kazemi Ali , Sahebdel Hosein , Ebrahimpour Majid
Published: November 2023

Background: Motivational psychotherapy has been investigated for its effects in the treatment of various disorders.
Objectives: This study aimed to examine the effectiveness of motivational psychotherapy in enhancing educational motivation among students.
Methods: This research employed a pretest-posttest quasi-experimental design with a control group. The study population comprised all female second-grade high school students in Birjand City during the 2022-2023 academic year. Purposive sampling was used to select a sample of 30 participants, who were then randomly assigned to the experimental (15 participants) and control groups (15 participants). The Harter Educational Motivation Inventory (1981) was used to collect data.
Results: The mean age of the experimental group was 17.23 years. The results of the analysis of variance (ANOVA) indicated that motivational psychotherapy had a significant impact on students’ educational motivation.
Conclusions: These findings emphasize the significance and effectiveness of motivational psychotherapy, offering new avenues for psychotherapists in the conceptualization and treatment of psychological issues in students.
Virtual Reality for Balance After Stroke: A Narrative Review
Authors: Poursaeed Fereshteh , Ansari Noureddin Nokhostin
Published: November 2023

Background: The present study was conducted to provide an up-to-date understanding of clinical applications in balance capability, as well as delivering a review of pieces of literature on Virtual Reality (VR) on balance control in stroke survivors.
Methods: Databases including PubMed, Cochrane Library, and Pedro were searched for published papers from 2010 to 2020 with the terms “Game-based rehabilitation”, “balance training”, “virtual reality”, “stroke”, “neurorehabilitation”, and “virtual environment”. We evaluated the effect of VR on balance improvement after a stroke.
Results: 33 articles describing results following the use of VR on balance in patients with stroke that met our inclusion criteria were found. Among these studies, two studies described the results in acute, eight in subacute, twenty-two in chronic stroke patients, and one study included both chronic and subacute stroke patients. The results indicated that balance can be improved with VR.
Conclusion: The results of this study strengthen the idea that VR training has the potential to become an effective adjacent to routine rehabilitation treatments for improving balance status post-stroke. However, conducting a randomized control trial that incorporates all three stroke phases with an appropriate study setting is necessary to achieve an integrated clinical protocol.
Tetracaine Effect on Pain Control within the First Day after Trans-Epithelial Photorefractive Keratectomy
Authors: Hasani Hamidreza
Published: November 2023

Background: This study was carried out to evaluate the effect of non-preserved tetracaine 0.5% on pain alleviation in the first 24 hr after Trans-epithelial Photorefractive Keratectomy (TPRK) excimer laser surgery.
Methods: This quasi-experimental study was conducted on 50 patients who were candidates for TPRK surgery using SCHWIND AMARIS 1050RS (eye-tech-solutions, Germany) excimer laser. One eye randomly received standard treatment including the eye drops of betamethasone, chloramphenicol, artificial tear, diclofenac, and diclofenac tablet (25 mg daily), and the fellow eye received standard treatment plus non-preserved tetracaine 0.5% drop every 4 hr. Post-operative pain was the main outcome measure, and the secondary outcome measures including burning sensation, epiphora, foreign body sensation, and photophobia were compared using Fisher’s exact test and ANOVA with a significance level of 0.05.
Results: Nineteen patients (38%) were male and 31 (62%) were female. Thirty patients (60%) reported no pain. The numeric scale of pain showed that the severity of pain was 4.4±0.8 for the cases’ eyes and 4.5±0.6 for the controls’ eyes, but the difference was not significant (p=0.75). Also, there was no difference regarding the burning sensation (p=0.49), epiphora (p=0.16), foreign body sensation (p=0.44), and photophobia (p=0.19). No significant difference was noted between the two groups.
Conclusion: Administering the eye drop of non-preserved tetracaine 0.5% every 4 hr had no significant effect on pain alleviation within the first day after TPRK surgery.
Exploring Cultural Competence in Business English:
Authors: Mebitil Nawal
Published: November 2023

In today’s globalised business world, effective communication and collaboration across cultures are crucial for success. Cultural competence, the ability to understand and navigate cultural differences, plays a vital role in achieving this. However, traditional language learning approaches often fail to adequately prepare learners for the cultural challenges they will face in professional contexts. English for Specific Purposes ‘ESP’ teaching, on the other hand, is well-suited to address this gap by integrating cultural content and skills into language teaching. This paper will explore the importance of cultural competence in Business English and discuss how ESP teaching can bridge the gap between traditional language learning and the needs of the business world. Precisely, the paper will aim to define cultural competence and its importance for Business English learners. It will also outline the challenges and opportunities for integrating cultural content and skills into ESP teaching. Additionally, it will answer the following question: How can ESP practitioners design and implement practical learning tasks to promote cultural competence in their students? The paper will conclude with a summary of the key findings and recommendations for ESP practitioners and syllabus designers.
Ujęzykowienie myśli poprzez pismo – analiza komunikacji pisemnej wybranej grupy dzieci ze spektrum autyzmu
Authors: Sedivy-Mączka Katarzyna
Published: November 2023

Możliwości porozumiewania się wpływają na jakość i komfort życia. Ważnym problemem jest sposób komunikacji niemówiących osób z autyzmem i dobór odpowiednich narzędzi do przekazywania myśli. Przedstawione w artykule badanie pilotażowe wskazuje na konieczność zgłębienia analizy porozumiewania się – za pomocą pisma – dzieci niemówiących, które nie rozpoczęły jeszcze nauki w szkole. Badani wykazywali znaczne ograniczenia w sposobie zapisywania, ale też widoczny był potencjał zastosowanego narzędzia w zakresie wypowiadania się. Zaburzony plan ruchu ogranicza możliwość mówienia oraz sprawność manualną, co przekłada się na ruchy ręki przy zapisywaniu. Dzięki pismu dzieci otrzymały szansę wypowiadania się w sposób swobodny, chociaż bez użycia głosu.
Nuestro contemporáneo Óscar Liera:
Authors: Velázquez Hernández Santos Javier
Published: November 2023

Este artículo aborda tres piezas «políticas» del dramaturgo Óscar Liera, El jinete de la Divina Providencia (1985), Los caminos solos (1987) y Camino rojo a Sabaiba (1988), a partir de la historia cultural. Con base en el concepto de representación, se estudia cómo el autor creó una identidad social mediante sus obras, entrevistas y cartas públicas, para enfrentar al autoritarismo del Estado en la época de los ochenta en México. Por medio del género de la farsa, con tópicos como la justicia social, la corrupción política o el cacicazgo, se propuso crear ciudadanía en el espectador/lector. Sus obras son el posicionamiento de un intelectual en el espacio público, cuya resistencia ética es indispensable aún en el escenario de la democracia latinoamericana.
Thermodynamic Properties of Seeds: A Review
Authors: Tamilarasan, C. , Jency, J. Poornima , Jerlin R.
Published: November 2023

Study of isotherms and thermodynamic properties become essential to understand the drying and imbibition mechanisms of seeds. Among post-harvest procedures of seeds, drying is widely known and used in order to assure quality and stability during storage and shelf life. Variation of moisture content through drying is important in order to understand the interaction between water molecules and the seed components, which is the key factor for correct drying and storage. Seed viability could be maintained during long periods owing to their glass structure, as a thermodynamic unstable state, with high viscosity. Thermodynamic properties were enthalpy (Amount of energy available to do work), entropy (Amount of energy present but it not available to do work) and gibbs free energy (Differential energy between the enthalpy and entropy). Thermodynamic properties of seed water determines the reaction kinetics during seed deterioration. Thermodynamic properties showed a critical upper limit, with tolerant species having higher values then susceptible species. In general the values of critical limits of the thermodynamic parameters decreased with increasing temperature. The differential enthalpy and entropy increased in seeds with period of storage and became asymptotic as the seed lost their viability. Thermodynamics properties increased with increase in temperature, indicating that drying and water absorption do not occur spontaneously it requires external energy. A radical drop in germination follows the trend of gibbs free energy increase and enthalpy decrease, indicating intensification of endergonic reaction. Hence, it is concluded that by using thermodynamic properties of seeds the seed quality can be determined without conducting the germination test in shortest period.
Estado del arte para la apreciación del valor cultural y económico de inmuebles habitacionales de mediados del siglo XX en México
Authors: Zavala Serrano Jorge , Mercado López Eugenio
Published: November 2023

Este artículo presenta la revisión el estado del arte para la apreciación del valor cultural y económico de los inmuebles habitacionales construidos a mediados del siglo XX (1940-1970) en México. A medida que estos edificios sobrepasan su vida útil material y como un esfuerzo para evitar su pérdida, se plantea la necesidad de comprender y preservar su valor cultural para las generaciones futuras. El estudio de la literatura comienza examinando el contexto histórico y social en el que se desarrollaron estos inmuebles ya que a mediados del siglo XX el mundo experimentó una serie de cambios significativos, incluyendo transformaciones económicas, sociales y tecnológicas. Estos factores tuvieron un impacto directo en la arquitectura y en el diseño de las viviendas de la época, creando una serie de corrientes distintivas que reflejaban la mentalidad y las aspiraciones de la sociedad de aquel entonces; pese a su valor arquitectónico, esos inmuebles no cuentan con una protección legal en México y, con frecuencia, son alterado o demolidos al ubicarse en áreas urbanas centrales que han adquirido un alto valor inmobiliario. Se aborda la importancia valorar estas edificaciones como hitos arquitectónicos y patrimonio cultural cuyo significado trasciende su función inicial como viviendas, al ser testimonio de una etapa en la historia urbanística, de valores y estilos de vida de quienes las habitaron. El análisis del estado del arte muestra la existencia de diferentes métodos y enfoques utilizados para apreciar y conjugar el valor económico y cultural de ese tipo de inmuebles, su impacto en la identidad y el sentido de pertenencia de una comunidad. El análisis permite advertir que existen desafíos para la salvaguarda de estos edificios en un contexto de una constante transformación social, económica y urbana, a partir de lo cual se discuten las implicaciones prácticas y las posibles recomendaciones derivadas de este análisis, concluyendo en la importancia de promover conciencia y educación sobre el valor cultural de estos inmuebles, tanto entre los profesionales del sector como en la sociedad en general.
Critical Appraisal of Electronic Surveys: An Integrated Literature Review
Authors: Keith Angela C. , Warshawsky Nora , Neff Donna , Loerzel Victoria , Parchment Joy
Published: November 2023

Background and Purpose:Electronic surveys are an essential data collection method in survey research but there are pros and cons. The purpose of this literature review was to understand the advantages and disadvantages of electronic surveys in research.Methods:An integrated literature review was performed.Results:Twenty publications met the criteria and were analyzed. The advantages of electronic surveys include speed, cost, convenience, flexibility, ease of analyses, global reach, reduced errors, and question diversity. The disadvantages of electronic surveys are response outcomes (nonresponse, item-nonresponse/poor completion rates, and careless responding errors) and digital literacy requirements.Conclusions:The advantages of electronic surveys outweigh their disadvantages, but researchers must understand the problems associated with electronic surveys and avoid them.
Enseñanza de parámetros fisicoquímicos de calidad en aceites para ingeniería de alimentos: implementación de trabajos prácticos de laboratorio
Authors: Vargas-Neira Samuel David , Rodríguez-Cepeda Rodrigo
Published: November 2023

El presente artículo muestra los resultados de una intervención didáctica piloto, en la cual se diseñaron e implementaron algunos Trabajos Prácticos de Laboratorio (TPL) contextualizados, con el propósito de evaluar su incidencia en el aprendizaje significativo de parámetros fisicoquímicos de calidad en aceites comestibles. La intervención se realizó con un grupo de 14 estudiantes de ingeniería de alimentos, donde se analizaron las respuestas de los estudiantes a cuestionarios inicial y final, además de informes de trabajo práctico, desde un enfoque cualitativo. Se identificó que el diseño e implementación de TPL favorecen el aprendizaje significativo de los conceptos químicos asociados a la calidad de los aceites en los ingenieros en formación. En este sentido, los TPL fomentan criterios para evaluar la calidad de un producto en cuanto a aceptación o rechazo, lo cual permite desarrollar habilidades para la toma de decisiones.
FAKTORS ASSOCIATED WITH THE INCIDENCE OF PREECLAMPSIA IN PREGNANT WOMEN AT RSUP. DR. M. DJAMIL PADANG IN 2022
Authors: Dewi Nur Cintia , Abdiana Abdiana , Fitrayeni Fitrayeni
Published: November 2023

Background: Preeclampsia still a complication of pregnancy is in need of special attention if not to be overcome by directly resulting in an increase in the number of deaths of pregnant women. The factors that can cause preeclampsia for pregnant women among them are age, parity, and the nutritional status of mothers. This research seeks to capture that deals with incident preeclampsia for pregnant women at RSUP Dr. M. Djamil Padang of 2022. Method: This research is quantitative research with an observational analytical design because there is no treatment of the objects studied. The research design used was cross sectional, that is, measurements and observations were carried out only once at a time. Result: The result showed 64,3 % preeclampsia pregnant women with heavy. This research result indicates the majority of pregnant women with a heavy risk preeklampsia 60,5 % ( p = 0,046; OR = 2,263; CI 95% = 1,081-4,736 ), the parity of risky 56,6 % ( p = 0,040; OR = 2,297; CI 95 % = 1,101-1,790 ) and nutritional status of risky 67,4 % ( p = 0,011; OR = 2,888; CI 95 % = 1,341-6,215) 95. Conclusion: It's concluded that there's an age relationship, parity and nutrition status of pregnant mothers against preeclampsia. Advice for health officials is particularly midwifes to increase counseling and socialization regarding pregnancy complications and raise caution to patients who are at risk of preeclampsia.
On the additive differential probability of ARX construction
Authors: Niu Zhongfeng , Sun Siwei , Hu Lei
Published: November 2023

Aim

The additive differential cryptanalysis is a significant technique used in the analysis of ARX ciphers. In this paper, we will focus on accurately and efficiently calculating the additive differential probability of $$ x \lll d \oplus y \lll e $$ .

Methods

Inspired by the work of Niu et al . at Crypto 2022, we use a delicate partition of $$ \mathbf{F}_2^m \times \mathbf{F}_2^m $$ into subsets.

Result

We derive an algorithm that can calculate it with linear time complexity. Compared with our algorithm, the one proposed by Velichkov et al . is only suitable when $$ e=0 $$ .

Conclusion

For the ARX construction: $$ (x \boxplus y) \lll d \oplus y \lll e $$ , which appears in Alzette, Speck, etc. , our algorithm can find more accurate additive differential characteristics for such ARX constructions. It is essential to evaluate the resistance of such ARX primitives against Additive differential cryptanalysis.
Recent advances in the marketing, impurity characterization and purification of quartz
Authors: Xie Yongping , Li Suqin , Pan Xiaodong , Li Yongkui , Zhang Ao
Published: November 2023

Due to its stable physical and chemical properties and its abundance in nature, quartz is widely employed in industrial and high-tech applications. However, the presence of diverse types and states of impurities in quartz ores from different geological formations poses a challenge in the process of purifying high-purity quartz, leading to wastage of raw materials and escalated costs. This study presents the socio-economic applications of quartz, scrutinizes the formation and separation mechanisms of impurities in quartz ores from a mineralogical perspective, examines the obstacles faced in quartz purification, explains the current state of development, and provides a technical summary of quartz purification. The analysis reveals that lattice impurity elements and various types of inclusion impurities are the principal factors affecting the purity of quartz. Various green separation techniques are applied based on the composition of the quartz minerals and the state of the impurities. Standard practices may involve physical pre-treatment such as scrubbing, ultrasonic crushing, and electromagnetic pulse cracking, followed by rough cleaning through color separation, superconducting high gradient magnetic separation, and flotation, and chemical pre-treatment (high-temperature or microwave roasting with chloride doping, and ammonium sulfate thermal crushing combined with water quenching to remove gas-liquid inclusions from quartz minerals). Finally, finishing processes such as fluorine-free and catalytic hot-pressure acid leaching or microbiological purification treatment with filamentous or Aspergillus fungi are used to obtain high-purity silica sand with an anticipated purity of about 99.99%.
The Consumer Protection Act, 2019: A critical analysis from a medical practitioner’s perspective
Authors: Vajawat Bhavika , Dinakaran Damodharan , Nandimath Omprakash V , HC Arpitha , Kumar Channaveerachari Naveen , Basavarajappa Chethan , Bada Math Suresh
Published: November 2023

The landmark judgment in the case of Indian Medical Association v VP Shantha in 1995 brought the medical profession under the ambit of the Consumer Protection Act, 1986. The Consumer Protection Act, 1986, was later repealed and replaced by the Consumer Protection Act, 2019. This article delves into the implications of the 2019 Act, highlighting significant changes in its scope, including the expansion of the definition of "consumer" and the incorporation of telemarketing and e-commerce within its ambit. Moreover, the amendments affect pecuniary jurisdiction, grounds for litigation, and introduce mediation cells, and the Central Consumer Protection Authority (CCPA). This article underscores concerns related to an increase in frivolous cases against medical practitioners and in defensive practice, ultimately impacting the overall quality of patient care. Recommendations for timely redressal and safeguards against unwarranted litigation are proposed to mitigate the adverse implications of the amended Act and ensure the well-being of both healthcare providers and patients.
ARCHEOLOGICAL ATTRACTIONS WITHIN INTENTION TO PARTICIPATE IN ARCHEOTOURISM: A CASE IN ÇORUM, TURKEY
Authors: KEMENT Üzeyir , ERKOL BAYRAM Gül , VALERİ Marco , BAŞAR Berkan , TUCE GÜNĞÖR Zekiye
Published: November 2023

Purpose – This paper examines the effect of the attractive motivational factors of archaeotourism on the intention to participate in archaeotourism. Methodology- The statistical program SmartPLS was used for data analysis. Design- The population consists of tourists who visited Çorum/Turkey, and convenience sampling method was applied. Four hundred and seventy tourists participated in the research between July and August 2022. Findings – Core archeological attractions, historical-cultural knowledge, leisure activities and archeotourism’development of the destination have a positive effect on the intention to participate in archaeotourism. On the other hand, additional archeological attractions and participatory archeological activities do not significantly influence the intention to participate in archaeotourism.” Originality of the research – The study includes exceptional variables to demonstrate the impact of attractive motivational factors on the intention to participate in archaeotourism. Furthermore, the statistical analysis provides desirable motivational factors for archaeotourism to determine the intention to visit archaeotourism sites. Thus, the research enables the determination of visitation intention for a destination in the context of archaeotourism and attempts to bridge the gap between tourists’ decisions and their visits. By modeling the effects of archaeotourism incentives on tourists’ visitation intentions, evidence and knowledge gaps in the literature are also addressed.
Can Machine Learning Change the Future of Basic Income Model by Predicting Future Vulnerability to Poverty?
Authors: Khalili Hamed
Published: November 2023

Appeals to governments for implementing basic income are contemporary. The theoretical backgrounds of the basic income notion, only prescribe transferring equal amounts to individuals irrespective of their specific attributes. However, the most recent basic income initiatives all around the world are attached to certain rules with regard to the attributes of the households. This approach is facing significant challenges to appropriately recognize the vulnerable groups. A possible alternative for setting rules with regard to the welfare attributes of the households is to employ artificial intelligent algorithms that can process unprecedented amounts of data. Can integrating machine learning change the future of basic income by perdition of vulnerable to future poverty households? In this paper, we utilize a multidimensional and longitudinal welfare data comprising one and a half million individual data and a Bayesian beliefs network approach to examine the feasibility of predicting households’ vulnerability to future poverty based on the existing households’ welfare attributes.
Establishment of a Novel Cancer-Specific Anti-HER2 Monoclonal Antibody H2Mab-250/H2CasMab-2 for Breast Cancers
Authors: Kaneko Mika K , Suzuki Hiroyuki , Ohishi Tomokazu , Tanaka Tomohiro , Kato Yukinari
Published: November 2023

Overexpression of human epidermal growth factor receptor 2 (HER2) in breast and gastric cancers is an important target for monoclonal antibody (mAb) therapy. All therapeutic mAbs, including anti-HER2 mAbs, exhibit adverse effects probably due to the recognition of antigens expressed in normal cells. Therefore, tumor-selective or specific mAbs can be beneficial in reducing the adverse effects. In this study, we established a novel cancer-specific anti-HER2 antibody, named H2Mab-250/H2CasMab-2 (IgG1, kappa). H2Mab-250 reacted with HER2-positive breast cancer BT-474 and SK-BR-3 cells. Importantly, H2Mab-250 did not react with non-transformed normal epithelial cells (HaCaT and MCF 10A) and immortalized normal epithelial cells in flow cytometry. In contrast, most anti-HER2 mAbs including H2Mab-119 (IgG1, kappa) reacted with both cancer and normal epithelial cells. Furthermore, a core-fucose deleted IgG2a-type H2Mab-250 (H2Mab-250-mG2a-f) could trigger the antibody-dependent cellular cytotoxicity activity to BT-474, but not to HaCaT cells. Furthermore, H2Mab-250-mG2a-f exhibited an in vivo antitumor effect against BT-474 xenograft. Immunohistochemical analysis demonstrated that H2Mab-250 possesses much higher reactivity to the HER2-positive breast cancer tissues compared to H2Mab-119, and did not react with normal tissues, including heart, breast, stomach, lung, colon, kidney, and esophagus. The epitope mapping demonstrated that the Trp614 of HER2 domain IV mainly contributes to the recognition by H2Mab-250. H2Mab-250 could contribute to the development of chimeric antigen receptor-T or antibody-drug conjugates without adverse effects for breast cancer therapy.
Knowledge and Attitude of First Aid Measures among Drivers in Sharjah
Authors: Mohamadiyeh Amjad Majed , Said Mohammed Ra'a , AlDabbagh Banan Aymen , Badawi Rana Saeed , Alhaboobi Furqan Hayder , Aljuwaied Maitha Abdulla , Shorbagi Sarra Ibrahim , Hussein Amal
Published: November 2023

Background: Injury is an important cause of mortality and morbidity.(1). FA is the immediate assistance provided to a suddenly injured or sick person until professional help arrives or that person has recovered.(2), could be a potential factor differentiating between life and death in RTA . Many lives would be saved if proper first aid is provided early. (3) In the middle east, there are limited studies that explore knowledge and practices towards first aid needed during RTA. Objective: The main aim of this study is to investigate the knowledge and attitude towards first aid among drivers in Sharjah. Methodology: A cross-sectional study was conducted through a self-administered questionnaire written in Arabic and English languages. Participants were 18 years or older holding a driving license in the city of Sharjah. Paramedics and certified participants with a certification from authorized organizations were excluded . A non-proportional convenient sampling method was used. A total of 343 participants have completed the questionnaires. Data was entered and analysed using SPSS. Results: Majority of the study participants were less than 40 years old and (56.76%) were males. Most participants(94.2%) indicated that they know the term ‘First Aid’. However, (49.73%) of the participants knew the ambulance number and (52.43%) of the participants indicated that the victim should be moved to the hospital without the ambulance. With regards to attitude, 34.86% were not willing to provide first aid in the case of RTA. The main reason was lack of knowledge followed by fear of legal consequences. Most participants (83,78%) were willing to participate in first aid classes to improve their knowledge and attitude. Conclusion: Most participants are aware of the basic term of first aid; however, they are not willing to provide first aid in cases of RTA due to lack of knowledge and fear of legal consequences. Based on these findings we recommend providing first aid classes for new drivers and to obtain certification. References: 1 and 3. Midani, O., Tillawi, T., Saqer, A., Hammami, M., Taifour, H. and Mohammad, H., 2020. Knowledge And Attitude Toward First Aid: A Cross-Sectional Study In The United Arab Emirates. 2.Van de Velde S, Heselmans A, Roex A, Vandekerckhove P, Ramaekers D, Aertgeerts B. Effectiveness of nonresuscitative first aid training in laypersons:A systematic review. Ann Emerg Med 2009;54:447-57, 457e1-5.
An Extended UTAUT Model for Analyzing Users’ Acceptance Factors for Artificial Intelligence Adoption in Human Resource Recruitment: A Case Study of Thailand
Authors: Wongras Piriyapong , Tanantong Tanatorn
Published: November 2023

Recruitment is a fundamental aspect of Human Resource Management to drive organizational performance. Traditional recruitment processes, with manual stages, are time-consuming and inefficient. Artificial Intelligence (AI), which demonstrates its potential in various sectors such as healthcare, education and notable cases of ChatGPT, is currently reshaping recruitment by automating tasks to improve efficiency. However, in Thailand, where there is a growing demand for talents, the application of AI in recruitment remains relatively limited. This research focuses on human resources (HR) and recruitment professionals in Thailand, aiming to understand their perspectives on the integration of AI in recruitment. It extended the Unified Theory for Acceptance and Use of Technology (UTAUT) model, customized to suit the specific requirements of Thai recruitment practices. The study explores the factors influencing users' intention to adopt AI in recruitment. Survey questionnaire items were created based on prior literatures and refined with insights from HR and recruitment experts to ensure applicability in the context of recruitment in Thailand. A survey involving 364 HR and recruiting professionals in Bangkok metropolitan area supplied comprehensive responses. The research reveals that several factors, including Perceived Value, Perceived Autonomy, Effort Expectancy, and Facilitating Conditions, significantly impact the intention to adopt AI for recruitment. While Social Influence and Trust in AI Technology do not have a direct influence on intention, Social Influence directly affects Perceived Value. Trust in AI Technology positively influences Effort Expectancy. This study provides valuable benefits for HR and recruitment professionals, organizations and AI developers by offering insights into AI adoption and sustainability, enhancing recruitment processes and promoting the effective use of AI tools in this sector.
Heat Stress Tolerant-QTL Identified Using Backcrossed Recombinant Inbred Lines Derived From Intra-specifically Diverse Aegilops tauschii Accessions
Authors: Ahmed Monir Idres Yahya , Kamal Nasrein Mohamed , Gorafi Yasir Serag Alnor , Abdalla Modather Galal Abdeldaim , Tahir Izzat Sidahmed Ali , Tsujimoto Hisashi
Published: November 2023

In the face of climate change, bringing more useful alleles and genes from wild relatives of wheat is crucial to develop climate-resilience varieties. We used two populations of backcrossed recombinant inbred lines (BIL1 and BIL2), developed using two intra-specifically diverse Aegilops tauschii accessions from lineage 1 and lineage 2, respectively, and backcrossing to common wheat cultivar ‘Norin 61’. The study aimed to identify quantitative trait loci (QTL) associated with heat stress (HS) tolerance. The two BILs were evaluated under heat stress environments in Sudan for phenology, plant height (PH), grain yield (GY), biomass (BIO), harvest index (HI), and thousand kernel weight (TKW). Grain yield was significantly correlated with BIO and TKW under HS; therefore, stress tolerance index (STI) was calculated for these traits as well as for GY. A total of 16 heat tolerant lines were identified based on GY and STI-GY. The QTL analysis performed using inclusive composite interval mapping identified a total of 40 QTLs in BIL1 and 153 QTLs in BIL2 across all environments. We detected 39 QTLs associated with GY-STI, BIO-STI, and TKW-STI in both populations (14 in BIL1 and 25 in BIL2). The QTL associated with STI were detected on chromosomes 1A, 3A, 5A, 2B, 4B, and all the D-subgenomes. We found that QTL detected only under HS for GY on chromosome 5A, TKW on 3B and 5B, PH on 3B and 4B, and grain filling duration on 2B. The higher number of QTLs identified in BIL2 for heat stress tolerance suggests the importance of assessing the effects of intraspecific variation of Ae. tauschii in wheat breeding as it could modulate the heat stress responses/adaptation. Our study provides useful genetic resources for uncovering heat-tolerant QTLs for wheat improvement for heat stress environments.
Virtual Journeys, Real Engagement: Analyzing User Experience in a Virtual Traveling Social Platform
Authors: Nazare Ana-Karina , Moldoveanu Alin , Moldoveanu Florica
Published: November 2023

A sustainable smart tourism ecosystem relies on building digital networks that link tourists to destinations. This study explores how web and immersive technologies, such as the VRRO platform, can improve tourism by offering interactive experiences to augment traditional travel. The study underscores the role of VRRO's design in enhancing user interaction and engagement, thereby encouraging the generation of user content and the development of a virtual tour network. An empirical analysis investigates user engagement, revealing that the platform is accessible to users regardless of their technological familiarity. It suggests a high likelihood of sustained use and recommendations. In conclusion, VRRO demonstrates how accessible and innovative technologies in tourism modernize travel experiences and significantly contribute to the evolution of the broader tourism ecosystem.
Enhancing Outlier Detection in Healthcare Data through Mahalanobis Distance Metric Analysis
Authors: Rajamani Santhosh Kumar , Iyer Radha Srinivasan
Published: November 2023

Mahalanobis distance is a useful multivariate statistic for determining how far apart two points are from one another. It is a very helpful statistic with excellent uses in multivariate anomaly detection, one-class classification, and classification on severely unbalanced datasets.
Computation Analysis of Histone Deacetylases With Curcumin
Authors: FERRARI IVAN VITO
Published: November 2023

The assessment of Histone deacetylases in conjunction with Curcumin, conducted through the Mcule Database employing the Autodock Vina algorithm, involves an examination of molecular interactions. This analysis includes the calculation of binding energies, revealing the strength and stability of the interactions between Curcumin and various Histone deacetylase targets. The comparison encompasses diverse aspects such as binding energies, specific binding sites, interactions across different targets, structural details, and potential implications for biological activity. The results imply that Curcumin shows heightened affinity for Histone deacetylase 4 in comparison to other investigated histone deacetylases.
The Existence and Averaging Principle for Caputo Fractional Stochastic Delay Differential Systems with Poisson Jumps
Authors: Bai Zhenyu , Bai Chuanzhi
Published: November 2023

In this paper, we obtain the existence and uniqueness theorem for solutions of Caputo type fractional stochastic delay differential systems (FSDDSs) with Poisson jumps by utilizing delayed perturbation of Mittag-Leffler function. Moreover, by using Burkholder-Davis-Gundy's inequality, Doob's martingale inequality and Holder inequality, we prove that the solution of the averaged FSDDSs converges to that of the standard FSDDSs in the sense of Lp. Some known results in the literature are extended.
Experimental Investigation on the Effect of Heating Oil and TPO Combustion on Different Stoichiometric Ratios, Flame Penetration, Emission Characteristics, and Soot Formation in an Evaporative Combustion Chamber
Authors: Kondor István Péter
Published: November 2023

This research aims to delve into the intricacies of combustion processes, specifically focusing on heating oil and a blend of heating oil with TPO (Tire Pirolysis Oil) in a self-developed evaporative combustion chamber featuring steam injection. The primary objective is to scrutinize the impact of steam injection on the combustion dynamics. Conducting a series of tests, the investigation involved the meticulous manipulation of stoichiometric ratios while introducing ambient air through gravity fuel flow. Subsequent iterations of these tests incorporated the introduction of steam into the ambient air stream. The examination encompassed the combustion of both heating oil and the TPO blend within the combustion chamber. The evaluation criteria comprised an in-depth analysis of flame characteristics, temperature distribution within the combustion chamber, and the quantification of emissions such as particulate matter (PM), nitrogen oxides (NOx), carbon dioxide (CO2), carbon monoxide (CO), and water vapor (H2O). Throughout the experimentation phase, commercially available diesel fuel served as the primary fuel source. To facilitate the tests, the combustion chamber under scrutiny was seamlessly integrated into an AVL engine test bench system. Essential parameters, including fuel consumption, were meticulously gauged using an AVL 735 fuel flow meter, while fuel temperature was monitored using the AVL 745 fuel temperature conditioning system. The intake air, a crucial element in the combustion process, was quantified with precision using an AVL Flowsonix sensor. Emission measurements were conducted meticulously using state-of-the-art equipment, with gaseous emissions analyzed using an AVL FTIR AMA i60 exhaust gas analyzer. Simultaneously, soot emissions were quantified through employment of an AVL Micro Soot sensor. This comprehensive approach not only delves into the fundamental aspects of combustion but also extends its reach to the exploration of innovative techniques, such as steam injection, to enhance combustion efficiency and reduce emissions. The integration of advanced measurement tools ensures a robust and thorough analysis of the combustion process and its environmental implications.
Tubular Endogenous Erythropoietin Protects Renal Function against Ischemic Reperfusion Injury
Authors: Yasuoka Yukiko , Izumi Yuichiro , Fukuyama Takashi , Oshima Tomomi , Yamazaki Taiga , Uematsu Takayuki , Kobayashi Noritada , Nanami Masayoshi , Shimada Yoshitaka , Nagaba Yasushi , Mukoyama Masashi , Sands Jeff M , Takahashi Noriko , Kawahara Katsumasa , Nonoguchi Hiroshi
Published: November 2023

Many large-scale studies revealed that exogenous erythropoietin, erythropoie-sis-stimulating agents, have no renoprotective effects. We investigated the effects of en-dogenous erythropoietin on renal function in ischemic reperfusion injury (IRI) of kidney using prolyl hydroxylase domaine (PHD) inhibitor, Roxadustat (ROX). 4 hr hypoxia (7% O2) and 4 hr treatment by ROX prior to IRI did not improve renal function. In contrast, 24-72 hr pre-treatment by ROX largely improved the decline of renal function by IRI. Hy-poxia and 4 hr ROX increased interstitial cells-derived Epo production by 75 and 6-fold, respectively, before IRI and worked as exogenous Epo. 24-72 hr ROX treatment increased Epo production during IRI by 9-fold. Immunohistochemistry revealed that 24 hr ROX caused Epo production in proximal and distal tubules and worked as endogenous Epo. Our data show that 24-72 hr ROX-induced tubular endogenous Epo production results in renoprotection but peritubular exogenous Epo production by interstitial cells-derived in-duced by hypoxia and 4 hr ROX did not. Stimulation of tubular but not peritubular Epo production may link to renoprotection.
A First Approach to Co-design with Pre-service Teachers a Multimodal Pedagogic Conversational Agent to Teach Programming in Primary Education
Authors: Pérez-Marín Diana , Hijón-Neira Raquel , Pizarro Celeste
Published: November 2023

Pedagogic Conversational Agents (PCAs) are interactive systems that engage the student in a dialogue to teach some domain. They can have the role of teacher, student, or companion, and adopt several shapes. In our previous work, a significant increase of students’ performance when learning programming was found when using PCAs in the teacher role. However, it is not common to find PCAs used in the classrooms. In this paper, it is explored whether teachers would accept PCAs to teach programming better if co-designed with them. An experiment with 35 pre-service Primary Education teachers was carried out during the 2021/2022 academic year to co-design a robotic PCA to teach programming. The experience validates the idea that involving the teachers in the design of the PCA facilitates that they integrate this technology in their classrooms. 97% of the pre-service teachers answered in a survey that they believed that the robot PCA could help children to learn programming and 80% answered that they would like to use them in their classrooms.
Redefining Literature Education in the Digital and Post-Pandemic Landscape
Authors: Eslit Edgar R.
Published: November 2023

In this inclusive review article, the focus is on navigating the dynamic landscape of literature education, particularly the profound pedagogical shifts observed in the aftermath of the pandemic. The article synthesizes global insights, delving into how educators have adapted to hybrid models and embraced digital tools, fundamentally transforming the reading, analysis, and engagement with literary works. Exploring the integration of digital tools in literature education, the review uncovers the transformative impact of technology on traditional pedagogies. It analyzes the challenges and opportunities inherent in adapting literature education to the digital era, emphasizing the need for inclusive practices and adaptability. The article concludes by suggesting future research directions, encompassing AI integration, inclusive practices, cultural variations, long-term effects of hybrid models, and effective pedagogical strategies for technology integration. With a comprehensive approach, this review not only summarizes the current state of literature education but also discusses its implications, offering a holistic understanding of the contemporary educational landscape and setting the stage for future research endeavors.
Bidirectional LSTM Autoencoder Transformer for Remaining Useful Life Estimation
Authors: Fan Zhengyang , Li Wanru , Chang Kuo-Chu
Published: November 2023

Estimating the Remaining Useful Life (RUL) of aircraft engines holds a pivotal role in enhancing safety, optimizing operations, and promoting sustainability, thus being a crucial component of modern aviation management. Precise RUL predictions offer valuable insights into an engine’s condition, enabling informed decisions regarding maintenance and crew scheduling. In this context, we propose a novel RUL prediction approach in this paper, harnessing the power of Bi-directional LSTM and Transformer architectures, known for their success in sequence modeling, such as natural languages. We adopt the encoder part of the full Transformer as the backbone of our framework, integrating it with a self-supervised denoising autoencoder that utilizes Bidirectional LSTM for improved feature extraction. Within our framework, a sequence of multivariate time series sensor measurements serves as the input, initially processed by the Bidirectional LSTM autoencoder to extract essential features. Subsequently, these feature values are fed into our Transformer encoder backbone for RUL prediction. Notably, our approach simultaneously trains the autoencoder and Transformer encoder, different from the naive sequential training method. Through a series of numerical experiments carried out on the C-MAPSS datasets, we demonstrate that the efficacy of our proposed models either surpasses or stands on par with that of other existing methods.