bluuebunny/crossref_metadata_2025 huggingface dataset:
A comparison between mobile and stationary gas chromatography–mass spectrometry devices for analysis of complex volatile profiles
Authors: Marcillo Andrea , Baca Cabrera Juan C. , Widdig Anja , Birkemeyer Claudia
Published: November 2022

On-site analysis of volatile organic compounds (VOCs) with miniaturized gas chromatography–mass spectrometry (GC–MS) systems is a very rapidly developing field of application. While, on the one hand, major technological advances are improving the availability of these systems on the market, on the other hand, systematic studies to assess the performance of such instruments are still lacking. To fill this gap, we compared three portable GC–MS devices to a state-of-the-art benchtop (stationary) system for analysis of a standard mixture of 18 VOCs. We systematically compared analytical parameters such as the sensitivity and similarity of the signal response pattern and the quality of the obtained mass spectra. We found that the investigated mobile instruments (i) showed different response profiles with a generally lower number of identified analytes. Also, (ii) mass spectral reproducibility (% relative standard deviation (RSD) of the relative abundance of selective fragments) was generally worse in the mobile devices (mean RSD for all targeted fragments ~9.7% vs. ~3.5% in the stationary system). Furthermore, mobile devices (iii) showed a poorer mass spectral similarity to commercial reference library spectra (>20% deviation of fragment ion relative intensity vs. ~10% in the stationary GC–MS), suggesting a less reliable identification of analytes by library search. Indeed, (iv) the performance was better with higher-mass and/or more abundant fragments, which should be considered to improve the results of library searches for substance identification. Finally, (v) the estimation of the signal-to-noise ratio (S/N) in mobile instruments as a measure of sensitivity revealed a significantly lower performance compared to the benchtop lab equipment (with a ratio among medians of ~8 times lower). Overall, our study reveals not only a poor signal-to-noise ratio and poor reproducibility of the data obtained from mobile instruments, but also unfavorable results with respect to a reliable identification of substances when they are applied for complex mixtures of volatiles.

Graphical Abstract
Clinical pitfalls and serological diagnostics of MuSK myasthenia gravis
Authors: Kwon Young Nam , Woodhall Mark , Sung Jung-Joon , Kim Kwang-Kuk , Lim Young-Min , Kim Hyunjin , Kim Jee-Eun , Baek Seol-Hee , Kim Byung-Jo , Park Jin-Sung , Seok Hung Youl , Kim Dae-Seong , Kwon Ohyun , Park Kee Hong , Sohn Eunhee , Bae Jong Seok , Yoon Byung-Nam , Kim Nam-Hee , Ahn Suk-Won , Choi Kyomin , Oh Jeeyoung , Park Hyung Jun , Shin Kyong Jin , Lee Sanggon , Park Jinseok , Kim Seung Hyun , Seok Jung Im , Bae Dae Woong , An Jae Young , Joo In Soo , Choi Seok-Jin , Nam Tai-Seung , Kim Sunyoung , Park Ki-Jong , Kwon Ki-Han , Waters Patrick , Hong Yoon-Ho
Published: November 2022

Background

We aimed to evaluate the diagnostic accuracy of enzyme-linked immunosorbent assay (ELISA) for anti-muscle specific tyrosine kinase (MuSK) antibody (Ab) in a large cohort of anti-acetylcholine receptor (AChR) Ab-negative generalized myasthenia gravis (MG), and also to investigate clinical contexts for the diagnosis of MuSK MG.

Methods

A retrospective study of 160 patients with a clinical suspicion of AChR Ab-negative generalized MG was performed. The serum samples were tested for anti-clustered AChR Ab by cell-based assay (CBA), anti-MuSK Ab by ELISA, CBA and/or radioimmunoprecipitation assay (RIPA). Clinical data were compared between anti-MuSK Ab-positive MG and double seronegative (AChR and MuSK) MG groups.

Results

After excluding non-MG and clustered AChR Ab-positive patients, we identified 89 patients as a cohort of AChR Ab-negative generalized MG. Anti-MuSK Ab was positive by ELISA in 22 (24.7%) patients. While CBA identified five additional anti-MuSK Ab-positive patients, the results of ELISA were mostly consistent with CBA and RIPA with Cohen’s kappa of 0.80 and 0.90, respectively (p < 0.001). The most frequent differential diagnosis was motor neuron disease particularly of bulbar onset which showed remarkably overlapping clinical and electrophysiological features with MuSK MG at presentation.

Conclusion

While confirming the highest sensitivity of CBA for detecting anti-MuSK Ab, our results highlight the clinical pitfalls in making a diagnosis of MuSK MG and may support a diagnostic utility of MuSK-ELISA in clinical practice.
Role of the endothelial reverse mode sodium-calcium exchanger in the dilation of the rat middle cerebral artery during hypoosmotic hyponatremia
Authors: Klapczyńska Katarzyna , Aleksandrowicz Marta , Koźniewska Ewa
Published: November 2022

A decrease in serum sodium ion concentration below 135 mmol L−1 is usually accompanied by a decrease in plasma osmolality (hypoosmotic hyponatremia) and leads to the disorder of intracranial homeostasis mainly due to cellular swelling. Recently, using an in vitro model of hypoosmotic hyponatremia, we have found that a decrease in sodium ion concentration in the perfusate to 121 mmol L−1 relaxes the isolated rat middle cerebral artery (MCA). The aim of the present study was to explore the mechanism responsible for this relaxation. Isolated, pressurized, and perfused MCAs placed in a vessel chamber were subjected to a decrease in sodium ion concentration to 121 mmol L−1. Changes in the diameter of the vessels were monitored with a video camera. The removal of the endothelium and inhibition of nitric oxide-dependent signaling or the reverse mode sodium-calcium exchanger (NCX) were used to study the mechanism of the dilation of the vessel during hyponatremia. The dilation of the MCA (19 ± 5%, p < 0.005) in a low-sodium buffer was absent after removal of the endothelium or administration of the inhibitor of the reverse mode of sodium-calcium exchange and was reversed to constriction after the inhibition of nitric oxide (NO)/cGMP signaling. The dilation of the middle cerebral artery of the rat in a 121 mmol L−1 Na+ buffer depends on NO signaling and reverse mode of sodium-calcium exchange. These results suggest that constriction of large cerebral arteries with impaired NO-dependent signaling may be observed in response to hypoosmotic hyponatremia.
Follicular lymphoma and marginal zone lymphoma: how many diseases?
Authors: Laurent Camille , Cook James R. , Yoshino Tadashi , Quintanilla-Martinez Leticia , Jaffe Elaine S.
Published: November 2022

Follicular lymphoma (FL) and marginal zone lymphoma (MZL) are indolent mature B-cell neoplasms with variable clinical presentation and distinct histopathologic features. Recent advances in the biology and molecular characteristics of these lymphomas have further expanded our understanding of the heterogeneous nature of these lymphomas, with increasing recognition of specific disease entities within the broader categories of FL and MZL. Here, we discuss the conclusions of the 2022 International Consensus Classification of Mature Lymphoid Neoplasms (2022 ICC) dealing with FL, and review differences with the proposed WHO 5th Edition classification. We review issues related to grading and alternative forms of FL especially those lacking the genetic hallmark of FL, the t(14;18) chromosomal alteration. Among them, t(14;18)-negative CD23+ follicle center lymphoma has been proposed by the 2022 ICC as a provisional entity. Other follicle center–derived lymphomas such as pediatric-type follicular lymphoma, testicular follicular lymphoma, primary cutaneous follicle center lymphoma, and large B-cell lymphoma with IRF4 rearrangement are considered distinct entities separate from conventional FL. Importantly, large B-cell lymphoma with IRF4 rearrangement introduced as a provisional entity in the WHO 2017 is upgraded to a definite entity in the 2022 ICC. We also discuss diagnostic strategies for recognition of MZLs including splenic MZL, extranodal MZL (MALT lymphoma), and primary nodal MZL. The importance of molecular studies in the distinction among marginal zone lymphoma subtypes is emphasized, as well as their value in the differential diagnosis with other B-cell lymphomas.
Evaluation of a commercial coproantigen immunoassay for the detection of Toxocara cati and Ancylostoma tubaeforme in cats and Uncinaria stenocephala in dogs
Authors: Hauck Daniela , Raue Katharina , Blazejak Katrin , Hanna Rita M. , Elsemore David A. , Pantchev Nikola , Strube Christina
Published: November 2022

Coproantigen immunoassays (IDEXX Fecal Dx® antigen tests) were evaluated for their ability to identify Toxocara cati and Ancylostoma tubaeforme infections in cats and Uncinaria stenocephala infection in dogs. Five cats were experimentally infected with 500 embryonated eggs of T. cati, eight cats with 500 third-stage larvae (L3) of A. tubaeforme and seven dogs with 500 L3 of U. stenocephala. In addition to the three coproantigen tests, the course of infection was monitored by a combined sedimentation-flotation method with ZnSO4 as flotation medium (specific gravity: 1.28–1.30) and a modified McMaster method in case of copromicroscopically positive samples. Eggs of T. cati were first observed between 28 and 54 days post infection (dpi) in four of the five infected cats. In these four cats, positive roundworm coproantigen signals were obtained between 16 and 44 dpi. Positive coproantigen signal always preceded egg observations, but the interval varied between 6 and 30 days. Hookworm-specific positive coproantigen signals were detected in seven of the eight A. tubaeforme infected cats between 10 and 52 dpi, while consecutive egg excretion was observed in three cats between day 26 and 54 pi. Of these three, coproantigen signal preceded egg observation by 12 to 24 days. Four cats had positive coproantigen results in the absence of egg excretion, and one cat never achieved a positive result for egg or coproantigen. In six of seven U. stenocephala infected dogs, infection was confirmed by copromicroscopy between 16 and 24 dpi as well as for hookworm coproantigen between 10 and 14 dpi. Coproantigen signal was detected prior to egg observation by 2 to 14 days. No cross-reactions between the roundworm, hookworm und whipworm tests occurred in study animals. The results of this study demonstrate the ability of the coproantigen tests to detect the common roundworm and hookworm infections in cats and U. stenocephala infections in dogs as well as the ability to detect the prepatent stage of infection.
Aktuelle Rechtsfragen des Cross-Compliance (in Landwirtschaft und Umweltschutz) – Cross-Compliance im Umweltschutz und Landwirtschaft
Authors: Krimphove Dieter
Published: November 2022

Zahlreiche staatlicher Anreize – insbesondere GLÖZ und GAB – beeinflussen und steuern
die Entscheidungen des einzelnen Landwirtes. Die Anforderungen dieser finanziellen Anreize wollen auch
eingehalten sein. Hierzu hat sich ein Kontroll-System bestehend aus Anreiz- Gewährungen aber auch
-Verweigerungen und -Rücknahmen; das sog. Cross-Compliance entwickelt.

Nachfolgender Beitrag stellt dieses System in seinen wesentlichen Einzelheiten vor allem deswegen
dar, weil sich mit den Jahreswechsel 2022/2023 zahlreiche Neuerungen dieses Anreizsystems ergeben.
Habit Reversal Training and Variants of Decoupling for Use in Body-Focused Repetitive Behaviors. A Randomized Controlled Trial
Authors: Moritz Steffen , Penney Danielle , Bruhns Alina , Weidinger Sarah , Schmotz Stella
Published: November 2022

Background

Behavioral interventions hold promise in improving body-focused repetitive behaviors (BFRBs), such as hair pulling and skin picking. The effect of combining different treatment techniques is currently unknown.

Methods

In the framework of a randomized controlled crossover trial, 334 individuals with at least one BFRB were allocated either to a waitlist control or to three experimental conditions (1:1:1:1). Participants in the experimental condition received self-help manuals teaching habit reversal training (HRT), decoupling (DC) and decoupling in sensu (DC-is) during a six-week period. Treatment conditions differed only in the order of manual presentation. We examined whether applying more than one technique would lead either to add-on or interference effects.

Results

The three treatment conditions were significantly superior to the waitlist control group in the improvement of BFRBs according to intention-to-treat analyses at a medium effect size (all p ≤ 0.002, d = 0.52 – 0.54). The condition displaying DC first significantly reduced depressive symptoms (p = 0.003, d = 0.47) and improved quality of life (p = 0.011, d = 0.39) compared to the waitlist control. Those using more techniques concurrently showed the strongest decline in BFRB symptoms, even after controlling for days practiced. Participants rated all manuals favorably, with standard DC and HRT yielding greatest acceptability.

Discussion

Results tentatively suggest the concurrent application of different behavioral treatments for BFRBs leads to add-on effects. Results were superior when DC was practiced first, with positive effects extending to depressive symptoms and quality of life. Integrating the three techniques into one self-help manual or video along with other treatment procedures (e.g., stimulus control techniques) is recommended.
Ficus-mediated green synthesis of manganese oxide nanoparticles for adsorptive removal of malachite green from surface water
Authors: Hasan Ibrahem Mohamed Abouzeid , Salman Hassan M. A. , Hafez Olfat M.
Published: November 2022

The extract of ficus leaves was used to prepare manganese (IV) oxide nanoparticles (MnO2 NPs) for the first time. Several different analytical techniques were used to characterize the prepared MnO2 NPs. MnO2 has spherical crystals that are ~ 7 nm on average in size and have 149.68 m2/g of surface area and 0.91 cm3/g of total pore volume. Malachite green (MG) dye was then taken out of the water by adsorption using MnO2 NPs. Optimization of various adsorption parameters resulted in 188.68–277.78 mg/g maximum adsorption capacities at 298–328 K tested temperatures and 99.6% removal of 50 mg/L MG within 90 min using MnO2 dose of 0.01 g at pH 10 and 298 K. The results were tested using pseudo-first order, pseudo-second order, intraparticle diffusion, Elovich, and Liquid film kinetic models as well as Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich isotherm models. The most likely models to describe the adsorption process at 298 K are pseudo-second-order kinetics (R2 = 0.997) with a rate constant of 4 × 10−4 g/(mg.min) and Langmuir isotherm (R2 = 0.973). Additionally, the positive values of enthalpy change (3.91–67.81 kJ/mol) and the negative values of Gibb’s free energy (− 3.38 to − 19.7 kJ/mol) indicate that the process is endothermic, spontaneous, and thermodynamically feasible. MnO2 NPs sustained their adsorption efficiency at 90.4% after 5 sorption cycles. MnO2 appears to be more selective for MG in studies examining the adsorption of various cationic dyes. Lately, the biosynthesized MnO2 NPs can be utilized to remove MG from aqueous solutions effectively.
Keyword-augmented and semi-automatic generation of FESS reports: a proof-of-concept study
Authors: Kunz V. , Wildfeuer V. , Bieck R. , Sorge M. , Zebralla V. , Dietz A. , Neumuth T. , Pirlich M.
Published: November 2022

Introduction

Surgical reports are usually written after a procedure and must often be reproduced from memory. Thus, this is an error-prone, and time-consuming task which increases the workload of physicians. In this proof-of-concept study, we developed and evaluated a software tool using Artificial Intelligence (AI) for semi-automatic intraoperative generation of surgical reports for functional endoscopic sinus surgery (FESS).

Materials and methods

A vocabulary of keywords for developing a neural language model was created. With an encoder-decoder-architecture, artificially coherent sentence structures, as they would be expected in general operation reports, were generated. A first set of 48 conventional operation reports were used for model training. After training, the reports were generated again and compared to those before training. Established metrics were used to measure optimization of the model objectively. A cohort of 16 physicians corrected and evaluated three randomly selected, generated reports in four categories: “quality of the generated operation reports,” “time-saving,” “clinical benefits” and “comparison with the conventional reports.” The corrections of the generated reports were counted and categorized.

Results

Objective parameters showed improvement in performance after training the language model (p < 0.001). 27.78% estimated a timesaving of 1–15 and 61.11% of 16–30 min per day. 66.66% claimed to see a clinical benefit and 61.11% a relevant workload reduction. Similarity in content between generated and conventional reports was seen by 33.33%, similarity in form by 27.78%. 66.67% would use this tool in the future. An average of 23.25 ± 12.5 corrections was needed for a subjectively appropriate surgery report.

Conclusion

The results indicate existing limitations of applying deep learning to text generation of operation reports and show a high acceptance by the physicians. By taking over this time-consuming task, the tool could reduce workload, optimize clinical workflows and improve the quality of patient care. Further training of the language model is needed.
Die Kommunikativierung der Maschinen
Authors: Dogruel Leyla , Dickel Sascha
Published: November 2022

With chatbots, voice assistants, and social robots oriented towards the ideal of human communication and emulating it in design and fields of application, communication studies is challenged to deal with these “communicating” technical media. In our contribution we argue that for communication science the social theoretical differences between “human” and “machines” are less relevant than the conditions that make it more likely that an attribution of communicative competences to the machine occurs. Drawing on research on mediatization, we show how communication is produced, initiated, and stabilized under contemporary conditions. We then design a model that captures different degrees of attributions of communication to the machine (“Kommunikativierung”) driven by three driving forces: (1) the decline of human control over the communication process, (2) the rise of simulation of human mediation of meaning, and (3) the discursive attribution of communication to the machine.
Chikungunya: An Emerging Public Health Concern
Authors: Mourad Omar , Makhani Leila , Chen Lin H.
Published: November 2022

Purpose of Review

The worldwide spread of chikungunya over the past two decades calls for greater knowledge and awareness of the virus, its route of transmission, methods of diagnosis, and the use of available treatment and prevention measures.

Recent Findings

Chikungunya virus infection, an Aedes mosquito-borne febrile disease, has spread from Africa and Asia to Europe and the Americas and from the tropics and subtropics to temperate regions. International travel is a pivotal influence in the emergence of chikungunya as a global public health threat, as evidenced by a growing number of published reports on travel-related chikungunya infections. The striking features of chikungunya are arthralgia and arthritis, and the disease is often mistaken for dengue. Although mortality is low, morbidity can be profound and persistent. Current treatment for chikungunya is supportive; chikungunya vaccines and therapeutics are in development. Travelers planning to visit areas where the mosquito vectors are present should be advised on preventive measures.

Chikungunya is an emerging disease in the Americas. Frequent travel, the presence of at least two competent mosquito species, and a largely naïve human population in the Western Hemisphere create a setting conducive to future outbreaks. Awareness of the disease and its manifestations is critical to effectively and safely manage and limit its impact. Vaccines in late-stage clinical trials offer a new pathway to prevention.
Involuntary Celibacy: A Review of Incel Ideology and Experiences with Dating, Rejection, and Associated Mental Health and Emotional Sequelae
Authors: Sparks Brandon , Zidenberg Alexandra M. , Olver Mark E.
Published: November 2022

Purpose of Review

Incels (involuntary celibates) have recently garnered media attention for seemingly random attacks of violence. Much attention has centered around the misogynistic and violent discourse that has taken place in online incel forums as well as manifestos written by incels who have perpetrated deadly attacks. Such work overlooks the experiences and issues faced by incels themselves, the majority of which have not engaged in any violent behavior.

Recent Findings

A small number of studies have recruited incels. Results from these studies highlight the nuanced nature of the incel identity. It is also apparent that incels suffer from high levels of romantic rejection and a greater degree of depressive and anxious symptoms, insecure attachment, fear of being single, and loneliness.

Incels report significant issues pertaining to their mental, social, and relational well-being and may seek support from forums that often feature misogynistic and violent content.
Streamlined NTRU Prime on FPGA
Authors: Peng Bo-Yuan , Marotzke Adrian , Tsai Ming-Han , Yang Bo-Yin , Chen Ho-Lin
Published: November 2022

We present a novel full hardware implementation of Streamlined NTRU Prime, with two variants: a high-speed, high-area implementation and a slower, low-area implementation. We introduce several new techniques that improve performance, including a batch inversion for key generation, a high-speed schoolbook polynomial multiplier, an NTT polynomial multiplier combined with a CRT map, a new DSP-free modular reduction method, a high-speed radix sorting module, and new encoders and decoders. With the high-speed design, we achieve the to-date fastest speeds for Streamlined NTRU Prime, with speeds of 5007, 10,989, and 64,026 cycles for encapsulation, decapsulation, and key generation, respectively, while running at 285 MHz on a Xilinx Zynq Ultrascale+. The entire design uses 40,060 LUT, 26,384 flip-flops, 36.5 Bram, and 31 DSP.
Mechanical properties of additively-manufactured cellular ceramic structures: A comprehensive study
Authors: Zhang Xueqin , Zhang Keqiang , Zhang Bin , Li Ying , He Rujie
Published: November 2022

Cellular ceramic structures (CCSs) are promising candidates for structural components in aerospace and modern industry because of their extraordinary physical and chemical properties. Herein, the CCSs with different structural parameters, i.e., relative density, layer, size of unit cells, and structural configuration, were designed and prepared by digital light processing (DLP)-based additive manufacturing (AM) technology to investigate their responses under compressive loading systematically. It was demonstrated that as the relative density increased and the size of the unit cells decreased, the mechanical properties of one-layer CCSs increased. The mechanical properties of three-layer CCSs were more outstanding than those of the CCSs with one and two layers. In addition, structural configurations also played a vital role in the mechanical properties of the CCSs. Overall, the mechanical properties of the CCSs from superior to inferior were that with the structural configurations of modified body-centered cubic (MBCC), Octet, SchwarzP, IWP, and body-centered cubic (BCC). Furthermore, structural parameters also had significant impacts on the failure mode of the CCSs under compressive loading. As the relative density increased, the failure mode of the one-layer CCSs changed from parallel—vertical—inclined mode to parallel—vertical mode. It was worth noting that the size of the unit cells did not alter the failure mode. Inclined fracture took a greater proportion in the failure mode of the multi-layer CCSs. But it could be suppressed by the increased relative density. Similarly, the proportions of the parallel—vertical mode and the fracture along a specific plane always changed with the variation of the structural configurations. This study will serve as the base for investigating the mechanical properties of the CCSs.
Design Approaches, Functionalization, and Environmental and Analytical Applications of Magnetic Halloysite Nanotubes: A Review
Authors: Fizir Meriem , Liu Wei , Tang Xue , Wang Fangqi , Benmokadem Yassmine
Published: November 2022

Researchers have long been committed to developing alternative, low-cost nanomaterials that have comparable capacity to carbon nanotubes. Halloysite nanotubes (HNTs) are naturally hollow, multi-walled, tubular structures that have high porosity, enlarged volumes and surface areas, and hydroxyl groups ready for modification. In addition, HNTs are non-toxic, biocompatible, inexpensive, abundant in nature, and easy to obtain. Magnetic nanocomposites have aroused widespread attention for their diverse potential applications in analytical fields and so magnetic halloysite nanotubes (MHNTs) have emerged as outstanding magnetic nano-adsorbent materials. Owing to their superparamagnetism, selective adsorption ability, and easy separation and surface modification, these captivating nanomaterials excel at extracting and enriching various analytes from environmental, biological, and food samples. The current review article gives an insight into recent advances in the design, functionalization, characterization, and application of MHNTs as magnetic, solid-phase extraction sorbents for separation of antibiotics, pesticides, proteins, carcinogens such as polycyclic aromatic hydrocarbons (PAHs), dyes, radioactive ions, and heavy-metal ions in complex matrices.
Robust Index Selection for Stochastic Dynamic Workloads
Authors: Schlosser Rainer , Weisgut Marcel , Hübscher Leonardo , Nordemann Oliver
Published: November 2022

Fast query processing is a primary goal of modern database systems. The use of indexes is crucial to reduce the execution times of database queries. Hence, it is of great interest to determine an efficient selection of indexes for a database management system (DBMS). However, index selection problems are highly challenging as indexes cause additional memory consumption and the individual benefit of an index is influenced by the selection of others. In this paper, we consider index selection problems accounting for non-standard features, such as (i) multiple potential workloads, (ii) different risk-averse objectives, (iii) multi-index configurations, (iv) reconfiguration costs, and (v) anticipation of dynamic workload scenarios. For the different problem extensions, we propose specific model formulations, which can be solved efficiently using solver-based solution techniques. The applicability and performance of our concepts are demonstrated using reproducible synthetic workloads as well as standard TPC-H and TPC-DS-based benchmark workloads.
Understanding the psychosocial needs of breast cancer survivors in the United Arab Emirates: a qualitative study
Authors: Aamir Maria , Al Ameri Mouza , Ganesan Subhashini , Alharmoudi Fatima , Alshehhi Anood , Alhashmi Fatima , Alawlaqi Dina , Cantarutti Flavia Martinez , Dubrow-Marshall Linda , Dubrow-Marshall Roderick , Zaher Walid Abbas
Published: November 2022

Background

Breast cancer is the most common cancer among women in the United Arab Emirates; yet there is little known about the psychosocial concerns of the survivors. Research shows that meeting the psychosocial needs significantly contributes to cancer survivor’s wellbeing and potentially elevates the quality of the patient’s life. Therefore the study aims to understand the psychosocial needs of breast cancer survivors through a qualitative approach.

Methods

A qualitative study was conducted using semi structured in-depth interviews among ten breast cancer survivors. The recorded texts were coded and salient themes were generated using an inductive approach. Thematic analysis of the interviews was done observing for meaning, repeating phrases and keywords.

Results

Analysis yielded three major themes which included survivors’ living experience with breast cancer, concerns of breast cancer survivors and the survivors’ expectations of healthcare delivery or support needed. The breast cancer survivors had psychosocial concerns that are not well understood and addressed by the healthcare. The experiences, concerns and expectations differ from individuals and through the continuum of survivorship.

Conclusion

Understanding the unmet psychosocial concerns of the cancer survivors is essential to design a structured survivorship program and offer timely and effective interventions. This would improve survivorship care in the country and offers opportunities to redesign cancer services towards patient-centred care.
Magnetic field effects on the quantum spin liquid behaviors of NaYbS2
Authors: Wu Jiangtao , Li Jianshu , Zhang Zheng , Liu Changle , Gao Yong Hao , Feng Erxi , Deng Guochu , Ren Qingyong , Wang Zhe , Chen Rui , Embs Jan , Zhu Fengfeng , Huang Qing , Xiang Ziji , Chen Lu , Wu Yan , Choi E. S. , Qu Zhe , Li Lu , Wang Junfeng , Zhou Haidong , Su Yixi , Wang Xiaoqun , Chen Gang , Zhang Qingming , Ma Jie
Published: November 2022

Spin-orbit coupling is an important ingredient to regulate the many-body physics, especially for many spin liquid candidate materials such as rare-earth magnets and Kitaev materials. The rare-earth chalcogenides "Equation missing" (Ch = O, S, Se) is a congenital frustrating system to exhibit the intrinsic landmark of spin liquid by eliminating both the site disorders between "Equation missing" and "Equation missing" ions with the big ionic size difference and the Dzyaloshinskii-Moriya interaction with the perfect triangular lattice of the "Equation missing" ions. The temperature versus magnetic-field phase diagram is established by the magnetization, specific heat, and neutron-scattering measurements. Notably, the neutron diffraction spectra and the magnetization curve might provide microscopic evidence for a series of spin configuration for in-plane fields, which include the disordered spin liquid state, 120° antiferromagnet, and one-half magnetization state. Furthermore, the ground state is suggested to be a gapless spin liquid from inelastic neutron scattering, and the magnetic field adjusts the spin orbit coupling. Therefore, the strong spin-orbit coupling in the frustrated quantum magnet substantially enriches low-energy spin physics. This rare-earth family could offer a good platform for exploring the quantum spin liquid ground state and quantum magnetic transitions.
Molecular beam epitaxy growth of few-layer stanene
Authors: Zang Yunyi , Zhu Kejing , Li Lin , He Ke
Published: November 2022

Two-dimensional topological materials, especially quantum spin Hall insulators, have attracted enormous research interest owing to their potential for applications ranging from low-power electronics to fault-tolerant quantum computation. Stanene—the tin counterpart of graphene—is a promising candidate for room-temperature quantum spin Hall insulators, motivated by its simple atomic structure and considerable band-inversion gap. Nevertheless, one key challenge is to fabricate topological non-trivial stanene on insulating substrates. In this Perspective, we review recent developments in experimental routes to the creation of few-layer stanene films on various substrates. A quantitative comparison between these stanene films on different substrates is also presented.
Grating-free 2.8 μm Er:ZBLAN fiber chirped pulse amplifier
Authors: Zhou Yicheng , Qin Zhipeng , Zhou Xiabing , Xie Guoqiang
Published: November 2022

We report on a grating-free fiber chirped pulse amplifier (CPA) at 2.8 μm for the first time. The CPA system adopted Er:ZBLAN fiber with large anomalous dispersion as the stretcher and germanium (Ge) rods as the compressor with a compact structure. High-energy picosecond pulses of 2.07 μJ were generated at the repetition rate of 100 kHz. Using highly dispersive Ge rods, the amplified pulses were compressed to 408 fs with a pulse energy of 0.57 μJ, resulting in a peak power of approximately 1.4 MW. A spectral broadening phenomenon in the main amplifier was observed, which was caused by the special gain shape of the Er:ZBLAN fiber amplifier in operation and confirmed by our numerical simulation. This compact fiber CPA system at 2.8 μm will be practical and meaningful for application fields.
The Growth of Finance is Not Remarkable
Authors: Brown James R. , Martinsson Gustav , Petersen Bruce C.
Published: November 2022

An important literature emphasizes that finance grew rapidly after WWII relative to the full economy and the services sector, but these are poor benchmarks because they mask a broad structural shift from low- to high-skill services. We show that i) finance is among the most skill-intensive service industries, ii) the evolution of the finance income share closely tracks other high-skill service industries, and iii) finance grew much slower than the rest of high-skill services in the post-WWII period. The rise of modern finance is not as remarkable as prior research suggests, providing context for debates about the size of finance.
Detailed analysis of cytoplasmic strings in human blastocysts: new insights
Authors: Eastick Jessica , Venetis Christos , Cooke Simon , Chapman Michael
Published: November 2022

The aim of this study was to determine if there was an association between the presence of cytoplasmic strings (CS) and their characteristics, with blastocyst quality, development and clinical outcome in human blastocysts. This two-centre cohort study was performed between July 2017 and September 2018 and involved a total of 1152 blastocysts from 225 patients undergoing in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). All embryos were cultured in Embryoscope+ and were assessed for CS using time-lapse images. A single assessor examined all blastocysts and reviewed videos using the EmbyroViewer® Software. Blastocyst quality was assessed on day 5 of embryo development. The number of CS, location and duration of their activity was recorded on days 5/6. A positive association between the presence of CS in human blastocysts with blastocyst quality was identified. Blastocysts with a higher number of CS present, were of higher quality and were in the more advanced stages of development. Top quality blastocysts had CS activity present for longer, as well as having a higher number of vesicles present travelling along the CS. Blastocysts that had CS present, had a significantly higher live birth rate. This study has confirmed that a higher number of CS and vesicles in human blastocysts is associated with top quality blastocysts and is not a negative predictor of development. They had a higher number of CS present that appeared earlier in development and, although ceased activity sooner, had a longer duration of activity. Blastocysts with CS had a significant increase in live birth rate.
Property rights aren't primary; ideas are
Authors: Wilson Bart J.
Published: November 2022

The current approach to the study of property cannot distinguish the causes of human action from the consequences of human action. It also cordons off morality thereby opening a hole in how property rights work. The scientific difficulty is that our analysis must constantly shift between the individual, their local community, and the larger polity in which both are embedded, in order to explain simultaneously different levels of consequences with different kinds of causes. The difficulty is made worse when we construct mental models without the human mind. My framework leaves the human mind in. Since Armen Alchian and Harold Demsetz, the study of property rights has had a decidedly external stance: the institution imposes itself on the individual from the outside. The problem of property rights, however, also calls for inquiry from the inside out of human agency, because in the study of property, ideas are primary.
Target-site and metabolic mechanisms of tolerance to penoxsulam in pond lovegrass (Eragrostis japonica)
Authors: Liu Ying , Wang Hao , Fang Jiapeng , Gao Haitao , Chen Jinyi , Peng Zhen , Dong Liyao
Published: November 2022

The identification of herbicide tolerance is essential for effective chemical weed control. According to whole-plant dose–response assays, none of 29 pond lovegrass [Eragrostis japonica (Thunb.) Trin.] populations were sensitive to penoxsulam. The effective dose values of penoxsulam causing 50% inhibition of fresh weight (GR50: 105.14 to 148.78 g ai ha−1) in E. japonica populations were much higher than the label rate of penoxsulam (15 to 30 g ai ha−1) in the field. This confirmed that E. japonica was tolerant to penoxsulam. Eragrostis japonica populations showed 52.83- to 74.76-fold higher tolerance to penoxsulam than susceptible barnyardgrass [Echinochloa crus-galli (L.) P. Beauv.]. The mechanisms of tolerance to penoxsulam in E. japonica were also identified. In vitro activity assays revealed that the penoxsulam concentration required to inhibit 50% of the acetolactate synthase (ALS) activity (IC50) was 12.27-fold higher in E. japonica than in E. crus-galli. However, differences in the ALS gene, previously found to endow target-site resistance in weeds, were not detected in the sequences obtained. Additionally, the expression level of genes encoding ALS in E. japonica was approximately 2-fold higher than in E. crus-galli after penoxsulam treatment. Furthermore, penoxsulam tolerance can be significantly reversed by three cytochrome P450 monooxygenase (CytP450) inhibitors (1-aminobenzotriazole, piperonyl butoxide, and malathion), and the activity of NADPH-dependent cytochrome P450 reductase toward penoxsulam in E. japonica increased significantly (approximately 7-fold higher) compared with that of treated E. crus-galli. Taken together, these results indicate that lower ALS sensitivity, relatively higher ALS expression levels, and stronger metabolism of CytP450s combined to bring about penoxsulam tolerance in E. japonica.
Microphysical Structure of Thunderstorms and Their Lightning Activity During the mei‐yu and Post‐mei‐yu Periods Over Nanjing, Yangtze River Delta
Authors: Yang Ji , Zhao Kun , Zheng Yuanyuan , Chen Haonan , Chen Gang
Published: November 2022

Using polarimetric radar, cloud‐to‐ground (CG) lightning, and reanalysis data, this study examined the microphysical structures of thunderstorm and their environmental impact during two active monsoon periods over Nanjing, Yangtze River Delta. The results show that the mei‐yu thunderstorm presented a large area of radar echo and many graupels between 0 and −10°C levels; these were accompanied by large vertical wind shear, which was favorite for the organization of thunderstorm. Broad updrafts within the mei‐yu thunderstorms were hypothesized, causing lower amount of dilution and entrainment, facilitating transportation of supercooled liquid water to the mixed‐phase region and producing CG lightning. Due to large atmospheric instability, strong updrafts within the post‐mei‐yu thunderstorm were expected to supply supercooled liquid water for the riming process to form more graupel above −10°C level. These provided favorable conditions for electrification, resulting in more CG lightning during the post‐mei‐yu period than during the mei‐yu period.
Global Mapping of Mesoscale Eddy Vertical Tilt
Authors: Li Hong , Xu Fanghua , Wang Guihua
Published: November 2022

Vertical motion induced by oceanic mesoscale eddies can strengthen ocean ventilation, and regulate vertical distribution of heat, dissolved CO2 and other tracers on a global scale. Eddy‐induced vertical motion is closely related to eddy vertical structure. Here, based on available satellite observations and Argo profiles, we find that mesoscale eddies in global oceans are prevalently vertical tilted. Anticyclonic eddies are frequently tilted westward and poleward from 300 dbar up to sea surface, while cyclonic eddies are frequently tilted westward and equatorward. The horizontal tilting distance of eddies is significantly correlated (r ≥ 0.84) with the Burger number (the ratio of vertical stratification to planetary rotation and eddy size), indicating a strong constraint of Earth's rotation and ocean stratification on eddy vertical tilt. On average, the maximum vertical velocity in tilted circular eddies is at least one order of magnitude larger than that in non‐tilted circular eddies. This finding would improve estimates of eddy‐induced vertical motion, ventilation, so as to heat/salt and biogeochemical responses.
Scalings for Eddy Buoyancy Fluxes Across Prograde Shelf/Slope Fronts
Authors: Wei Huaiyu , Wang Yan , Stewart Andrew L. , Mak Julian
Published: November 2022

Depth‐averaged eddy buoyancy diffusivities across continental shelves and slopes are investigated using a suite of eddy‐resolving, process‐oriented simulations of prograde frontal currents characterized by isopycnals tilted in the opposite direction to the seafloor, a flow regime commonly found along continental margins under downwelling‐favorable winds or occupied by buoyant boundary currents. The diagnosed cross‐slope eddy diffusivity varies by up to three orders of magnitude, decaying from in the relatively flat‐bottomed region to over the steep continental slope, consistent with previously reported suppression effects of steep topography on baroclinic eddy fluxes. To theoretically constrain the simulated cross‐slope eddy fluxes, we examine extant scalings for eddy buoyancy diffusivities across prograde shelf/slope fronts and in flat‐bottomed oceans. Among all tested scalings, the GEOMETRIC framework developed by D. P. Marshall et al. (2012, https://doi.org/10.1175/JPO-D-11-048.1) and a parametrically similar Eady scale‐based scaling proposed by Jansen et al. (2015, https://doi.org/10.1016/j.ocemod.2015.05.007) most accurately reproduce the diagnosed eddy diffusivities across the entire shelf‐to‐open‐ocean analysis regions in our simulations. This result relies upon the incorporation of the topographic suppression effects on eddy fluxes, quantified via analytical functions of the slope Burger number, into the scaling prefactor coefficients. The predictive skills of the GEOMETRIC and Eady scale‐based scalings are shown to be insensitive to the presence of along‐slope topographic corrugations. This work lays a foundation for parameterizing eddy buoyancy fluxes across large‐scale prograde shelf/slope fronts in coarse‐resolution ocean models.
Heterogeneity in treatment outcomes and incomplete recovery in first episode psychosis: does one size fit all?
Authors: Griffiths Siân Lowri , Lalousis Paris Alexandros , Wood Stephen J. , Upthegrove Rachel
Published: November 2022

The heterogeneity in recovery outcomes for individuals with First Episode Psychosis (FEP) calls for a strong evidence base to inform practice at an individual level. Between 19–89% of young people with FEP have an incomplete recovery despite gold-standard evidence-based treatments, suggesting current service models, which adopt a ‘one-size fits all’ approach, may not be addressing the needs of many young people with psychosis. The lack of consistent terminology to define key concepts such as recovery and treatment resistance, the multidimensional nature of these concepts, and common comorbid symptoms are some of the challenges faced by the field in delineating heterogeneity in recovery outcomes. The lack of robust markers for incomplete recovery also results in potential delay in delivering prompt, and effective treatments to individuals at greatest risk. There is a clear need to adopt a stratified approach to care where interventions are targeted at subgroups of patients, and ultimately at the individual level. Novel machine learning, using large, representative data from a range of modalities, may aid in the parsing of heterogeneity, and provide greater precision and sophistication in identifying those on a pathway to incomplete recovery.
Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesis
Authors: Boiarsky Rebecca , Haradhvala Nicholas J. , Alberge Jean-Baptiste , Sklavenitis-Pistofidis Romanos , Mouhieddine Tarek H. , Zavidij Oksana , Shih Ming-Chieh , Firer Danielle , Miller Mendy , El-Khoury Habib , Anand Shankara K. , Aguet François , Sontag David , Ghobrial Irene M. , Getz Gad
Published: November 2022

Multiple myeloma is a plasma cell malignancy almost always preceded by precursor conditions, but low tumor burden of these early stages has hindered the study of their molecular programs through bulk sequencing technologies. Here, we generate and analyze single cell RNA-sequencing of plasma cells from 26 patients at varying disease stages and 9 healthy donors. In silico dissection and comparison of normal and transformed plasma cells from the same bone marrow biopsy enables discovery of patient-specific transcriptional changes. Using Non-Negative Matrix Factorization, we discover 15 gene expression signatures which represent transcriptional modules relevant to myeloma biology, and identify a signature that is uniformly lost in abnormal cells across disease stages. Finally, we demonstrate that tumors contain heterogeneous subpopulations expressing distinct transcriptional patterns. Our findings characterize transcriptomic alterations present at the earliest stages of myeloma, providing insight into the molecular underpinnings of disease initiation.
Nickel-catalyzed switchable 1,3-dienylation and enantioselective allenylation of phosphine oxides
Authors: Zhang Jiayin , Chang Xihao , Xu Xianghong , Wang Hongyi , Peng Lingzi , Guo Chang
Published: November 2022

The development of general catalytic methods for the regio- and stereoselective construction of phosphoryl derivatives from identical substrates remains a formidable challenge in organic synthesis. Enabled by the newly developed BDPP-type ligands, we disclosed a nickel-catalyzed allenylation of phosphine oxides rationally and predictably, allowing the construction of versatile chiral allenylphosphoryl derivatives with high enantiopurity (up to 94% e.e.). Alternatively, using an achiral phosphine ligand dcypbz under acidic conditions, we achieved a regiochemical switch of the 1,3-dienylation to afford functionalized phosphinoyl 1,3-butadienes (up to 93% yield). The salient features of this method include switchable reactivity, broad substrate scope, readily available feedstock, single-step preparation, and high asymmetric induction.
Constructing molecular bridge for high-efficiency and stable perovskite solar cells based on P3HT
Authors: Xu Dongdong , Gong Zhiming , Jiang Yue , Feng Yancong , Wang Zhen , Gao Xingsen , Lu Xubing , Zhou Guofu , Liu Jun-Ming , Gao Jinwei
Published: November 2022

Poly (3-hexylthiophene) (P3HT) is one of the most attractive hole transport materials (HTMs) for the pursuit of stable, low-cost, and high-efficiency perovskite solar cells (PSCs). However, the poor contact and the severe recombination at P3HT/perovskite interface lead to a low power conversion efficiency (PCE). Thus, we construct a molecular bridge, 2-((7-(4-(bis(4-methoxyphenyl)amino)phenyl)−10-(2-(2-ethoxyethoxy)ethyl)−10H-phenoxazin-3-yl)methylene)malononitrile (MDN), whose malononitrile group can anchor the perovskite surface while the triphenylamine group can form π−π stacking with P3HT, to form a charge transport channel. In addition, MDN is also found effectively passivate the defects and reduce the recombination to a large extent. Finally, a PCE of 22.87% has been achieved with MDN-doped P3HT (M-P3HT) as HTM, much higher than the efficiency of PSCs with pristine P3HT. Furthermore, MDN gives the un-encapsulated device enhanced long-term stability that 92% of its initial efficiency maintain even after two months of aging at 75% relative humidity (RH) follow by one month of aging at 85% RH in the atmosphere, and the PCE does not change after operating at the maximum power point (MPP) under 1 sun illumination (~45oC in N2) over 500 hours.