Effects of icosapent ethyl according to baseline residual risk in patients with atherosclerotic cardiovascular disease: results from REDUCE-IT
Authors: Burger Pascal M , Bhatt Deepak L , Dorresteijn Jannick A N , Koudstaal Stefan , Mosterd Arend , Martens Fabrice M A C , Steg Philippe Gabriel , Visseren Frank L J ,   for the REDUCE-IT Investigators, Ladner Joanne , Kakish Lily , Kakish Ashley , Little Amy L , Gerber Jaime , Hinchion Nancy J , Guarino Janet , Raychok Denise , Budzinski Susan , Kelley-Garvin Kathleen , Beckord April , Schlinder Jessica , Schwartzbard Arthur , Cobos Stanley , Freeman Deborah , Abisalih David , McCann Dervilla , Guy Kylie , Chase Jennifer , Samuelson Stacey , Cassidy Madeline , Tardif Marissa , Smith Jaime , Sprout Brenna , Riedeman Nanette , Goza Julie , Johnson Lori , Kraske Chad , Hastings Sheila , Dutka Chris , Smith Stephanie , McCabe Toni , Maloney Kathleen , Alfieri Paul , Hosemane Vinay , Syravanh Chanhsamone , Pau Cindy , Limcoiloc April , Carreira Tabitha , Kurosawa Taryn S , Kurosawa Taryn S , Krumian Razmig , Preston Krista , Nashed Ashraf , Schneidman-Fernandez Daria , Patterson Jack , Tsakonas John , Esaki Jennifer , Sprafka Lynn , Patel Porous , Mitchell Brian , Ross Erin M , Miller Donna , Prashad Akash , Feyler Kristina M , Juarbe Natasha , Herrera Sandra , Keiran Sarah M , Whitehead Becky , Asher Whitney , Hobbs Coury , Elie Abbey , Brooks Jean , Zaleski Amanda L , Foxen Brenda , Lapke Barb , Wright Philippa , Pavol Bristol , Carangi Gwen , Turner Marla , Ellison Howard S , Sanders Katharine W , Delamar Rikita S , Wilson Virginia L , Harvel Sarah M , Cartledge Alison M , Bailey Kaitlyn R , Mahon Kathleen , Schuchard Timothy , Humbert Jen , Hanson Mark C , Cecil Michael P , Abraham James S , Benedict Lorie , Slayton Claudia , Burnett Curtis S , Ono-Lim Rachel W , Budzinski Sharon , Khan Shubi A , Goss Sharon , Techmanski Terry , Valliani Farida , Joseph Rimla , Flores Edith , Contreras Laurn , Aguillon Ana , Silvia Carrie-Ann , Martin Maria , Kerut Edmund K , Levenson Leslie W , Glade Louis B , Cospolich Brian J , Stein Maureen W , LaGuardia Stephen P , Sonza Thelma L , Fife Tracy M , Forschler Melissa , Watts Jasmyne , Fritsch Judy , Futchko Emese , Utech Sarah , Baker Scott B , Roura Miguel F , Sutton David R , Segel Scott A , Magee James S , Jackson Cathy , Goldfaden Rebecca F , Quas Liudmila , Ortiz Elizabeth C , Simpson Michael , Foster Robert , Brian C , Trimm James , Bailey Michael , Snoddy Brian , Reeder Van , Wilkinson Rachel , Settle Harold , Massey Cynthia , Maiola Angela , Hall Michele , Hall Shelly , Hall Wanda , Xenakis Mark , Barrett Janet , Campanile Giovanni , Anthou David , Neill Susan F , Karas Steven , Polanco Enrique , Schechtman Norberto , Tischner Grace , Warren Kay , Cyr Cynthia St , Kuczinski Menna , Alexander Latrina , Ibarra Maricruz , Horowitz Barry S , Steinsapir Jaime , Mangual-Coughlin Jeanette , Mooney Brittany , Vasquez Precilia , Rodkey Kathleen , Biberstein Alexandria , Ignacio Christine , Robinson Irina , Hibberd Marcia , Hoffman Lisa B , Murak Daniel J , Varavenkataraman Raghupathy , Elliott Theresa M Ohlson , Cunningham Linda A , Palmerton Heather L , Poole Sheri , Moore Jeannine , Wallace Helene , Chandler Ted , Riley Robert , Dawood Farah , Azeem Amir , Cammarata Michael , Owen Ashleigh , Aggarwal Shivani , Qureshi Waqas , Almahmoud Mohamed , Oseni Abdullahi , Leigh Adam , Barnes Erin , Pflum Adam , Aladin Amer , Blinson Karen , Wayne Vickie , Doomy Lynda , Wall Michele , Bitterman Valerie , Young Cindi , Grice Rachel , Poliakova Lioubov , Davalos Jorge , Rosenbaum David , Boulware Mark , Mazzola Heather , Strader J Russell , Linsky Russell , Schwartz David , Graf Elizabeth , Gneiting Alicia , Palmblad Melissa , Donlin Ashley , Ensminger Emily , Garcia Hillary , Robinson Dawn , Tran Carolyn , Jacqmein Jeffrey , Bartilucci Darlene , Koren Michael , Maluchnik Barbara , Parks Melissa , Miller Jennifer , DeFosse Cynthia , Knouse Albert B , Delancey Amy , Chin Stephanie , Stephens Thomas , Sohal Mag , Ingram Juana , Kumar Swarooparani , Foley Heather , Smith Nina , McKinney Vera , Schwarz Linda , Moore Judith , Anderson H V , SdringolaMaranga Stefano , Denktas Ali , Turrentine Elizabeth , Patterson Rhonda , Marshall John , Tolar Terri , Patrick Donna , Schwartzkopf Pamela , Fletcher Anthony M , Harris Frances R , Clements Sherry , Brown Tiffany , Smith William , Baehl Stacey J , Fluty Robin , VanHamersveld Daniel , Breen Dennis , Bender Nancy , Stafford Beverly , Washington Tamika , Pike Margaret N , Stich Mark A , Jawad Evyan , Nadeem Amin , Nyland Jill , Hamer Rhonda , Calhoun Kendra , Mall Charlotte , Cadogan Samuel , Raynes Kati , Katz Richard , Marshall Lorraine , Abbas Rashida , Dinerman Jay L , Hartley John T , Lamb Beth , Eskridge Lisa , Raymond Donna , Clemmer Kristy , Fine Denise M , Beardsley Paula , Werner Janet , Mahan Bette , VanTol Courtney , Herman Robert , Raiser-Vignola Christine , McShan Felicia , Neill Stefanie A , Blick David R , Liston Michael J , Nelson Denetta K , Dorrell Sandra K , Wyman Patricia , Quraishi Ambereen , Ferro Fernando , Morris Frank , Coombs Vicki J , Mains Autumn M , Campbell Austin A , Phelps Jeanne , Geary Cheryl A , Sheridan Ellen G , Downing Jean M , Swatkowski Arie , Redden Tish , Dragutsky Brian , Thomas Susan , Mitchell Candace , Barker Diana , Turcotte Elanie , Segerson Deborah , Guy Jill , De La Mora Karena , Hong Jennifer , Do Dennis , Norris Rose , Khan Faisal , Montero Hector , Kelly-White Stacy , Cleland Alan , Alcalde-Crawford Rosalyn , Morgan Melissa , Sarabu Brijmohan , Minor Megan , Kamat Shweta , Estes Stephanie M , Harless Nancee , Disney Alicia , Pagano Jodi L , Alford Chad M , Bedwell Noel W , Hardy Warren D , DeAndrade Kevin , Elmore Jessica G , Auerbach Eric G , Haney Anthony W , Brooks Miriam H , Torres Jose , Roper Lois , Backer Terry , Backer Katie , Roper Lois , Evans John G , Magee James S , Silva Ricardo A , Dajani Lorraine H , Segel Scott A , Yousif Veronica , Ross Tammy , Goldfaden Rebecca F , Roy Sion K , Oudiz Ronald , Hamal Sajad , Flores Ferdinand , Leahy Amor , Ayer Debra , George Swapna , Stewart Chrisi Carine , Orellana Elvira , Boccalandro Cristina , Rangel Mary , Hennings Suzanne , Vanselow Carl , Victor Teri , Birdwell Darlene , Haas Paul , Sandoval Anthony , Ciavarella Gina , Saglam Caroline , Bird Amy , Beck Keith , Poliquin Brian , Dominguez David , Tenorio Brittany , Perkins Harvonya , Roman Esther San , Bransford Paris , Lowrance Christy , Broussard Marcy , Ellis Mary , Skiles Bobbi , Hamilton Jessica , Hall Kathryn , Olvera Diego , Maloney Kathleen , Hartwell Julee A , Sorial Nevien , Anand Kishlay , Rickman Mary , Berman Kevin , Mehta Nirav , Laborin Annie , Saglam Caroline , Rothenberger Rodger , Beauvilliers Sarah , Morrell Kathy , Schachter Michael P , Perkins Cindy L , Gordon Elizabeth A , Lauer Jennifer , Bichsel Kim , Oliver Kelly , Mellor Leslie J , Demattia Candice , Schomburg Jennifer , Moreno Yenniffer , Mansur-Garza Eduardo , Rippstein Lena , Chacon Lorie , Pena Andrea , King Michelle , Richardson Susan , Jessop Annette , Tucker Nicole , Royer Whitney , Templeton Gilbert , Moell Ann , Weller Christine , Botts Melissa J , Hollon Gretel , Homberg-Pinassi Elsa , Forest Paula , Abhulhak Aref Bin , Chun-Furlong Devona , Harrington Deborah , Harlynn Emily , Schmitt Marjorie , Shelsky Constance , Feldick Patricia , Cherrico Mary , Jagle Courtney , Warnecke Nicholas , Myer Debra , Ruder Deanna J , Underwood Albina , Rauba Alan , Carr George , Oberhaus Barbara , Vanderfeltz Jessica , Stucky-Heil Mary Jo , Gibson Dale R , Fuentes Vonnie , Talbot Kimberly L , Simon William C , Grimes Katlyn J , Wheeler Christina R , Shultz Cassaundra , Metcalf Rhonda A , Hill Jennifer L , Oliver Michelle R , Ahmad Basharat , Azeem Fouzal , Rahim Abdul , Freeman George H , Bloch Dawn , Freeman Heather , Brown Jamie , Rosbach Sarah , Melander Pamela , Taralson Nick , Liu Alex , Harms Katlyn , Michale Mahfouz , Lopez Jose , Revoredo Maria , Edevane Shari , Shawley Sarah , Jackson Timothy L , Oliver Michael J , DeSalle Dina , Matlock Patricia J , Beraun Ionna M , Hendrix Heather , Bromley Garrett , Niemerski Ashley , Teran Gabby , Guerrero Sonia , Marvi Murtaza , Palanpurwala Zehra , Torres Andrea , Gloyd Patty , Conger Michelle , Pena Andrea , Laurent Aziz , Nayor Olia , Villanueva Catalina S , Khambati Munira , Mumford Tabetha J , Castillo Melanie J , Desta Taddese , Robinson Jerome , Woods La Shawn , Bahri Anita H , Herrera Nancy , Casaclang Cecilia , Unger Jeffrey R , Martinez Geraldine , Moon Mia K , Mohaupt Stephen M , Sandoval Larry , Valenzuela Louisito , Ramirez Victora , Mata Nelly , Avila Veronica , Patino Marisol , Montano-Pereira Cynthia , Barnett Omar , Webster William M , Christensen Lorraine M , Bofman Leighna , Livingston Melanie , Adams Stacey , Hobbs Joseph , Adams Stacey , Koskela Leesa , Katz Mia , Mujica-Trenche Samuel , Cala Franklin , Rana Noreen T , Scarlett Jennifer , Anaya Milagros Cala , Jones Marsha R , Hollis Kelly D , Roth Debbie , Eads Kristin , Watts Tina , Perkins Judy , Arnold Alice , Ginsberg Daniel C , Quinn Denise , Cureton Nicole , Fittingoff David B , Iqbal Mohammed I , White Stephen R , Sisneros Edith , Ducca Michelle , Streja David , Campos Danny , Boak Jennifer L , Amir Farzeen , Anderson Felice , Kmetzo James J , Bongarzone Mary O , Scott Dawn , De Leon Mary Grace , Buda Cynthia , Graettinger William , Alex Michelle , Graettinger William , Hess Erika , Govoni James , Bartel Melissa , Monchamp Travis L , Roach Julie S , Gibson Sara , Allfrey Amy M , Timpy Kristen , Bott Kathy , Soucy Karin A , Willis Jean , Valerio Cecilia A , Chunduri Anusha , Coker Rebecca , Vidrine Nicole , Thompson Ellen A , Studeny Mark A , Marcum Melissa K , Monway Tammy S , Kosmicki Douglas L , Kelley Melissa J , Godfrey Corey M , Krenk Susan L , Holcomb Randy R , Baehr Deb K , Trauernicht Mary K , Lowry David Rowland , Herts Betty Bondy , Phelps Jeanne E , Downing Jean-Marie , Dignon Carol Gamer , Cockrill Elisabeth S , Chapla Pravinchandra G , Fera Diane , Chang Margaret , Fredette Patricia , Ashby Tamie , Bergin Renee , Stearns Zebediah A , Ware David B , Boudreaux Rachael M , Miranda Francisco G , Rodriguez Joanna , McKenzie Robert , Huber Amanda , Sommers Rebecca , Rowe Heather , McLallen Stacy , Haynes Michale , Adamson Ashley , Henderson Janice , McClure Lori , Harris Beverly A , Ference Laura , Meissner-Dengler Sue , Treasure Lisa , Nicely Doreen , Light Timothy L , Osborn Tracey A , Mai Kimberly J , Vivas Pablo , Rios Jose , Rodriguez Dunia , DeRaad Roger , Walder James , Bailon Oscar , Hockett Denice , Anderson Debbie , McIntosh Kelli , Odegard Amber , Shepherd Andrew , Seifert Mary , Kelley Laurence , Shetty Rajendra , Castine Michael , Brill David , Fisher Gregory , Richmond Nicole , Gray Kathleen , Miller Patricia , Coneys Charlene , Chanza Yarixa , Sumoza Monica , Caudill Victoria M , Harris Kelly D , Manion Courtney A , Lineberger-Moore Melody J , Wolfe Julie J , Rosen Barbara J , DiVito Patricia , Moffat Janet L , Michaelis Christina , Koshy Prashant , Perea Diana , Yacoub Ghaith Al , Sadeghi Stephanie , LeGalley Thomas D , Evonich Rudolph F , Jean William J , Friesen Gary M , Pap John M , Pesola David A , Cowan Mark D , Dosh Kristofer M , Larson Dianna , Price Adele M , Nease Jodi A , Anderson Jane E , Piggott Lori A , Iwaoka Robert , Sharkey Kevin , McMillan Edward , Lowder Laurie , Morgan Latisha , Davis Kyle , Caldwell Tara , Breglio Erica , Summers Jasmine , Poulimas Rachel , Zahid Muhammad , Syed Hamid , Escobar Maria , Levy Jacob , Warsi Rahma , Ma Carol , Cen Puxiao , Cawthon Kimberly A , Barnes Delores B , Allen Deanna G , Warrington Margaret L , Stastny Carol R , Michaels Robin J , Saleh Mohamad , Sorin John , Rathod Sunny , Juett Urakay , Spencer Steven , Keval Aziza , McBride Jill , Young Shane , Baxter Catherine , Rasmussen Carol , Coxe Shari L , Campos Luis , Tavackoli Shahin , Beckham Diana , Sanchez Darlynee , Basrai Karanjit , Helms Dorian , Clinton Erica , Smith Kasie , Ghitis Arnold , Cusnir Henry , Clark Mary Klaus , Cherukuri Madhavagopal V , Scarfaru Ameta , Nash Stephen D , Moore Jeannine , Wallace Helene , Grimm Loretta C , Grace Anna , McElheran Kylie , Subasic Dino , Buhay Zedrick , Litvinoff Janet , Washington Tamika , Shah Deepak , Cervantes Shannon , Usher Freda , Yasser Farra , Trusevich Theodore , Garcia Ronnie L , Wyatt Jamison , Bose Rahul , Miska Holllilyn , Spivey Traci , Wren Amy B , Vance Katie E , Holman Lani L , Gibbons Pam , Eby Elaine , Shepard Sandra , Charoenthongtrakul Soratree , Snodgrass Brett , Nazem Mohammed , Keteenburg Shelly , Murthy Prathima , Prater Frederic , Rumfelt Ashley , Eizensmits Christina , Iannuzzi Lisa , Patel Pourus R , Bergamino Clellia , McFeaters Elizabeth , Rizk Botros , Pflaum Emiljia , Kalish Danny , Ambatali Rex , Ameli Mona , Sanguinetti Delaina , Ameli Mona , Vaidya Rakesh , Blinson Karen , Doomy Lynda , Wayne Vickie , Bos Rob J , Wils Alexandra , Jacobs Tamara , Badings Erik A , Ebels-Tuinbeek Lillian A , Scholten Mayke L , BayraktarVerver Esther , Zweers Debby , Schiks Manoek , Kalkman Carolien , Tiemes Tineke , Mulderij Jeanette , Hermans W , Dabrowska K , Wijnakker W , Loo R Vd , DeGraauw J , Reijnierse Giny , van der Zeijst Mirjam , Scholten Mariska , Hofmeijer Henk R , van Dijk-van der Zanden Antoinette , van Belle Dineke J , Van Es Jan , Van Buchem Gera , Zijda Wendy , Verheij Harald , Oldenhof-Janssen Linnea , Bader Martina , Löwik Marije , Stuij Sandra , Vantrimpont Pascal , van Aken Krista , Hamilton Karen , van der Weerdt Arno , Blömer Han , van Laerhoven Gabriela , Tukkie Raymond , Janssen Maarten , Verdel Gerard , Küpper Jon Funke , van Vlies Bob , Kalkman Caroline , Vooges Joke , Vermaas Marinella , de Graauw Jeanne , Van de Loo Riny , Langenberg Rachel , Haenen Niek , Smeets Frans , Scheepmaker Arko , Grosfeld Marcel , Van Lieshout Ilvy , van den Berg Marleen , Wittekoek Marian , Mol Petra , Stapel Antionette , Sierevogel M , vd Ven N , Berkelmans A , Viergever Eric , Kramer Hanneke , Engelen Wilma , Houwelingen Karen V , Wildbergh Thierry X , Mosterd Arend , Hobé-Rap Coriet , van Doorn Marjan , Bunschoten Petra , Freericks Michel , Emans Mireille , Den Boer-Penning Petra , Verlek Els , Freericks Christine , de Nooijer Cornelis , Welten Christina , Groenenberg Ingrid , van der Horst C , Vonk E , Tjeerdsma Geert , Jochemsen Gerard M , van Daalen Corinne , Danse Ingrid Y , Kuipers Lucy , Pieterse Anke , Oomen Antonius , de Waard Daan , Flu Willem Jan , Kromhout Zusan , Van der Bij Petra , Feld Rob , Hessels-Linnemeijer Brigitta , Lardinois Rob , Posma Jan L , Aukema-Wouda Zwanette R , Woerden Marjolijn Hendriks-van , van Wijk Desiree , Beelen Driek P , Hendriks Ingrid H , Jonker Jan J , Schipperen Stefanie , Köse Vicdan , Rojas Gloria , Goedhart Linda , van Meurs Hanneke , Langenberg Rachel , Rijssemus Jacqueline , Hoogendijk Jacqueline , Swinkels-Diepenmaat Lindy , van Kempen Wouter , de Louw-Jansen Marloes , Bierens-Peters Dominique , van Kempen Willem W , Wittekoek Marianne E , Agous Irmaina , Schenk Geert , van Kempen Willem W , Wittekoek Janneke , Cox Kevin , Julia Deborah F , Jonker Jan J C , Janssen Roel , van Kempen Willem W , Wittekoek Marianne E , Nierman Melchor , Katerberg Hilligje , Jonker Jan J C , van der Haar Irene , Van Kempen Willem W , van Mesdag Taco , Wittekoek Janneke , Jonker Jan J C , Costa Leyda M Alvarez , Schensema Manon , Zweekhorst Salomé , SwinkelsDiepenmaat Lindy , Schipperen Stefanie , van Kempen Willem W , Julia Deborah Font , Jonker Jan J C , Hanewinckel Lauri , Olsthoorn Joyce , Berends Johan C , van der Spek Arie C , van der Berg Roy , Timmermann Rob J , Boerema Ingrid , Mudruk Iryna , Khrystoforova Anna , Kyselov Serhii , Hilova Yaroslava V , Logoida Pavlo , Logoida Pavlo , Sanina Nataliia A , Golikova Ilona P , Nemchyna Olena O , Golikova Ilona P , Golikova Ilona P , Isaichikov Ivan I , Potapova Olga B , Gura Iurii V , Berestetska Larysa , Kulianda Olena O , Tantsura Oleksandr , Kulbachuk Oleksandr S , Petsentiy Volodymyr , Biskub Ihor , Biskub Ihor , Handych Tetyana , Lagkuti Oleg , Gagarina Alyna , Chendey Taras , Bilonko Oksana F , Matova Olena , Bezrodna Larysa , Yarynkina Olena , Ovdiienko Tetiana , Randchenko Volodymyr , Mospan Maryna , Ovdiienko Tetiana , Butko Olena , Romanenko Olga , Pavelko Mykhailo , Sichkaruk Iryna , Lazareva Svitlana O , Kudryk Olena A , Koltsun Inessa M , Koltsun Inessa M , Magdalits Tetiana , Zadorozhniy Sergei , Kompaniiets Kira , Ivanov Andrii , Romanenko Sergiy , Kaplan Pavlo , Romanov Vadym Y , Mykytyuk Oksana P , Zaitseva Nataliia S , Pyvovar Sergiy N , Burdeuna Lyudmyla , Serdobinska Emerita , Shevchenko Tatiana I , Ivanytskyi Igor I , Ivanytskyi Igor I , Ivanytskyi Igor I , Khyzhnyak Olena V , Smirnova Ganna , Kalinkina Nataliya , Keting Olena , Sklyanna Olena , Kashanska Olga , Shevelok Anna , Khristichenko Marina , Titov Ievgenii Y , Oleksander Danilenko O , Polenova Nataliia S , Altunina Nataliia , Kororaieva Viktoriia , Zborovskiy Stanislav , Kholopov Leonid , Suliman Iurii , Lukashenko Lanna , Shvaykin Stanislav , Glavatskiy Olexandr M , Sychov Roman O , Kulynych Roman L , Skarzhevskyi Oleksandr A , Dovgan Nataliia V , Horbach Marta , Cherkasova Olga , Tyshchenko Iryna , Todoriuk Liudmyla , Kizim Svitlana , Brodi Nataliia , Ivanko Oleksandr , Garbarchuk Olga , Alieksieieva Liudmyla , Shandra Tetiana L , Beregova Olena , Bodretska Larisa An , Naskalova Svitlana S , Antoniuk-Shcheglova Ivanna A , Bondarenko Olena V , Andreeva Natalia G , Vakalyuk Iryna I , Chovganyuk Olha S , Artemenko Nataliya R , Maltsev Kiril A , Kalishevich Natalia , Kondratyeva Natalia G , Nikitina Svetlana A , Martjanova Maria V , Sokolova Anna V , Dragunov Dmitrii O , Kolesnik Olga , Larina Vera , Tsygankova Oxana V , Ivanova Maria , Karpov Illia A , Aronova Elena M , Vedernikova Ekaterina S , Lubinskaya Ekaterina I , Burak Taras Y , Skichko Sergey I , Rasulev Farhad , Soldatova Ekaterina B , Fenin Alexander L , Laptev Ilya I , Luchinkina Elena E , Akatov Alexandr , Polenova Natalia V , Slavina Natalia N , Korovnika Irina N , Yu Prochorova Marina , Shakirova Regina , Andreicheva Elena N , Krasnova Olga A , Lobzhanidze Tinatin V , Dmitrova Tatiana B , Stakhiv Viktoriya V , Pechatnikova Maria I , Panova Alexandra V , Tipikina Maria Y , Rotar Oxana P , Bokovin Nikolay A , Karabalieva Saule K , Tumarov Farid Y , Vasileva Elena V , Lozhkina Natalya Gennadevna , Filippova Ekaterina V , Sharkaeva Alisa I , Filippova (Deilik) Ekanerina V , Yu Tolkacheva Natalia , Domracheva Elena N , Ryabikov Andrey N , Abesadze Inga T , Alugishvili Marianna Z , Nikolaeva Elena P , Smirnova Nadezda V , Rodionova Valentina I , Dolovstaya Polina V , Yunonin Igor E , Kadin Sergey V , Sveklina Tatyana S , Bushmanova Anna V , Bushmanova Anna V , Barkova Elena L , Gomova Irina S , Brytkova Yana V , Ivanova Tatiana B , Zubareva Marina Y , Skopets Inga , Galashevskaya Lybov A , Butinskaya Emilia D , Gusarova Olga G , Kalishevich Natalia B , Pavlova Yana R , Serebrenitskaya Marianna P , Grygorieva Vitalina F , Kuchaeva Gulnara R , Vasileva Inna A , Ospanova Gulnara I , Vahrusheva Yulia V , Semenova Irina A , Mikhailova Irina E E , Kvasova Olga O , Shurygina Valeria D , Rivin Alexey E , Savelyev Alexey O , Savelyev Alexey A , Milyaeva Olesya O , Lapshina Nadezhda N , Lantsova Ninel A , Alexandrov Pavel V , Orlikov Evgeniy A , Falkovskaya Alla , Ripp Tatiana , Triss Sergei , Pekarskiy Stanislav , Ekaterina Sitkova , Zhuravleva Evgeniya N , Perova Olga , Kovaleva Galina , Koroleva Liubov , Koroleva Liubov , Mishchenko Lydia , Garshin Boris P , Kutuzova Svetlana A , Provotorova Lyudmila I , Zadvorny Igor P , Okhapkina Olga V , Khrustalev Anatoly O , Suvorova Tatiana , Shaf Elena S , Vershinina Varvara A , Kozulin Andrey A , Oleynik Oxana A , Martynova Irina Y , Kizhvatova Natalia V , Salasyuk Alla S , Tsoma Vera V , Ledyaeva Alla A , Chumachek Elena V , Blignaut S C , Alexander Tersia Y , Du Plessis Chano , Govender Thirumani , Du Toit Samatha M , Motala Leya , Gassiep Areesh , Naude (Smit) Christina , Terblanche Marli , Snoer (Kruger) Marlien , Pillay Berenice , Basson De Vries , Corbett Clive H , Theron Marisa E , Fouche Bianca , Coetzee Mareli E , Odendall Pieter , Van Wijk Frederik H , Conradie Anna-Mari , Van der Westhuizen Trudie , Tredoux Carine , Mookdam Mohamed S , Van der Merwe Andie J , Snyman Karin , Smal Gerda , De Jager Yvonne , Mabin Thomas A , King Annusca , Henley Lindy L , Zwane Brenda M , Robinson Jane , Karsten Marinda , Page Andonia M , Nsabiyumva Valerie , Krahenbuhl Charmaine , Patel Jaiprakash D , Motala Yunus E , Dawood Ayesha , Koza Nondumiso B , Peters Lenore M S , Ramlachan Shavashni , Bodenstein Wilhelm J , Roux Pierre , Fouche Lizelle , Boshoff Cecilia M , Mitha Haroon M , Khan Fathima , Cyster Henry P , Cyster Helen , Wessels E C , Jacobs Florence J , Sebastian Melanie A , Sebastian Deborah A , Mahomed Nadia , Immink Ignatius P , Cotzee Celia , Cronje Tanja , Roscher Madele , Roux Maria Le , Trinder Yvonne A , Wnętrzak-Michalska Renata , Piszczek Magdalena , Piela Andrzej , Czernecka Ewa , Knychas Dorota , Walczak Alina , Gładysz Izabella , Filas Katarzyna , Kiluk Ewelina , Świgło Krzysztof , Jędrzejczyk Iwona , Łuczyńska Kamila , Tymendorf Katarzyna , Piesiewicz Wojciech , Kinasz Wojciech L , Samborski Stefan , Bartuś Ilona , Korecka Gramzyna Latocha , Gulaj Ewa , Sopa Jolanta , Derlaga Bogusław , Baisiak Marcin , Kowalisko Allicia , Stainszewska-Marasazlek Edyta , Szafran Bartosz , Swiatkiewicz Malgorzata , Racewicz Artur , Grycel Sławomir , Supronik Jerzy , Walendziuk Sylwia , Tarantowicz Magdalena , Stasiak Agata , Sidorowicz-Białynicka Anna , Dwojak Marek , Jaźwińska-Tarnawska Ewa , Kupczyk Katarzyna , Martowska Kamila , Kulon Kamila , Gajda Katarzyna , Wilson Bivin , Velusamy Krithika , Sadhiq Swaidha S , Siddeshi Bhavani , Bhanukumar M , Srivatsav Abhishek , Ramesh Madhan , Chalasani Sri Harsha , Johnson Mini , Gopu Prashanth , George Jeesa , Reddy Sowmya , Eleena Swetha Tessy Thara , Kodem Damodara Rao , Nakkella Haritha N , Mandula Padma Kumari , Vuriya Anjan Kumar , Rajana Syamala , Kale Aruna , Rajeev Tiwari , Jain Raina , Jain Vipin , Adhyapak Srilakshmi Mandayam , Sheeba Lumin , Uma C R , Ramya R , Kulkarni Aditya V , Ganachari M S , Sambrekar Ruma , Bilal Mohammad , Nungshijungla  , Chakravarthy Kalyan , Badhavath Ravi , Kumar Sravan , Simhadri Meenakshi , Salamuddin Farooque , Prasad Venkat , Dwivedi Vivek , Sarna Sudha , Arora Tilak , Chawla Deepak , Sathe Archana , Gayatree Chaware , Nanda Ajeet , Avtar Ram , Sharma Jyoti , Sasirekha D Vaibhavi P S , Kobbajji Deepthi , Ningappa Ramya , Shree Shwetha , Chandrashekar K , Nandini M R , Sowjanya S , Devika I G , Yashaswini N , Sonika G , Rathna L , Priyanka R , Shrimanker Rupal J , Reddy Lakshmi Vinutha , Sumathi K , Devi Babitha , Naik Bina N , Manjunath Rohini , Ashok Rajeshwari , Kunjumon Tony V , Thomas Jesline , Samdhani Shaik , Selvam Kasthuri , Subramani Poongothai , Parthasarathy Nandakumar , Bohra Nirmal K , Gatla Anvesh K , Horbatuk Cheryl , Sills Julie , Davey E B , Paramonczyk Liz , Racanelli Olga , Crowley David , Strybosch Sandy , Belanger Andre , Palardy Jean , Schiffrin Alicia , Gauthier Sylvie , Kalyniuk Norman , Whatley Shawn D , Lappala Heather , Patel Grishma , Reeve Matthew , Moran Catherine , Everitt Jody , Ferrari Teresa , Bouffard Christine , Frohlich Jirir , Francis Gordon , Mancini John , Bondy Gregory , DeAngelis Debbie , Fulton Patricia , DeAngelis Debbie , Fulton Patricia , Blank David W , Lombardo Angela , Roy Mylène , Chow Jackie , Fox Hyman , Grootendorst William J , Hutchinson Angela , Fox Hyman , Chan Sharon M , Fitzgerald Christie , Ferrari Teresa , Wilkins Lynn , Raymond Rebecca L , Reyes Arlene , André Lavoie Marc , Fortin Denis , Ouimet Hélène , Tôn-Nu Thanh-Thao , Dussureault Martine , Blain Marie-Hélène , Roy Madeleine , Kopajko Nathalie , Fleury Chantal , Maheux Karine , Ciobotaru Gabriela Valentina , Constantinescu Maria C , Gherghinescu Carmen-Lucia , Avram Ana-Maria , Manitiu Ioan , Cojan Radu I , Pirvu Octavian M , Sinpetrean Aura , Pop Lucian , Lupu Delia , Usvat Radu , Petrisor Ana , Dumitru Nicoleta , Moruju Camelia , Gheorghita Adelina , Mitu Magda V , Macarie Cosmin , Pop Ana Maria , Diaconu Maria-Catalina , Grancea Iulia , Cosma Mihaela , Cosma Mihaela , Crisan Mihaela , Herron Elizabeth , Dart Anthony M , Nestel Paul , Kay Sally B , Carter Kaye S , Badshah Imran , Makepeace Ashley , Drinkwater Jocelyn , England Michelle , Rafei Azette , Patterson Kylie , Jenkins Alicia , McAuley Sybil , Kent Sue M , Vibert Joy E , Perrett Leonie , David Thomas , Kaye Samantha L , O'Connor Monika , Perera Nimalie J , Lai Nicole T , Kearins Kerry A , Dicamillo Christinia , Anderson Heather , Ferguson Louise , Radtke Sharon D , Thamarappillil Charles T , Boys Janice M , Long Anita K , Shanahan Toni , Nyguyen Michael , Forrest Nicole , Tulloch Gill , Greenwell Della , Price Sarah L , Tint Aye N , Sumithran Priya K , Debreceni Tamara L , Walker Lisa , Caruana Mary , Edwards Kira , Stathopoulos Maria , Haywood Cilla , Sajkov Dimitar , Pringle Sharen , Tabner Anne , Bartolay Kathrina , Abeyratne Chamindi , Bragg Kylie , Mulhern Patrick , Purnell Peter , Hendriks Randall , Tulloch Gill , Williams Lyn , Hamlyn Jane , Connelly Aurelia , Hoffman Jan , Bailey Samantha , Kerr Jane , Morrison Zarnia , Maeder Sarah , McEwan Roberta , Kunasekera Prasanna , McGregor Patrice , Young Jo , Berry Sharon , Cutfield Rick , Choe Michelle , McNamara Catherine , Shergill Narrinder K , Crone Petra , Williams Miles G , Dyson Keith , Schmid Diana H , Doak Audrey C , Spooner Melissa , Edwards Colin , Turner Anne , McAnnalley Grainne M , Fisher Raewyn A , Hamilton Fraser B , Friedlander Denis H , Kirk Melissa R , Scales Jayne E , McLelland Marguerite A , Dalman Neelam A , Vickers Cathy E , Jackson Carolyn , Coleman Wendy , Garden Phillip I , Arnold Wendy F 
Published: April 2024

Aims

Icosapent ethyl lowers triglycerides and significantly reduces major adverse cardiovascular events (MACE), though treatment effects may vary between individuals. This study aimed to determine the relative and absolute effects of icosapent ethyl on MACE according to baseline cardiovascular disease (CVD) risk in patients with atherosclerotic cardiovascular disease (ASCVD).

Methods and Results

Participants from the Reduction of Cardiovascular Events with Icosapent Ethyl—Intervention Trial (REDUCE-IT) with ASCVD were included (n = 5785). The primary outcome was 3-point MACE, i.e. non-fatal myocardial infarction, non-fatal stroke, or cardiovascular death. Baseline 5-year risk of MACE was estimated using the European Society of Cardiology (ESC) guideline-recommended SMART2 risk score. Modification of the relative treatment effects of icosapent ethyl by baseline risk was assessed using Cox proportional hazards models, including a treatment-by-risk interaction. Next, treatment effects were assessed stratified by quartiles of baseline risk. During a median follow-up of 4.8 years (interquartile range 3.2–5.3), MACE occurred in 361 vs. 489 patients in the icosapent ethyl vs. placebo group [95% confidence interval (CI)]; hazard ratio (HR) 0.72 (0.63–0.82), absolute risk reduction (ARR) 4.4% (2.6–6.2%), number needed to treat (NNT) 23 (16–38), and 5-year Kaplan-Meier estimated cumulative incidence reduction (CIR) 5.7% (3.5–7.9%). Icosapent ethyl significantly reduced MACE in all risk quartiles, with an HR (95% CI) of 0.62 (0.43–0.88), 0.66 (0.48–0.92), 0.69 (0.53–0.90), and 0.78 (0.63–0.96), respectively (P for treatment-by-risk interaction = 0.106). The ARR (95% CI) increased across risk quartiles, i.e. was 3.9% (1.0–6.8%), 4.3% (1.2–7.3%), 5.1% (1.4–8.7%), and 5.6% (1.3–10.0%), respectively. This translates to NNTs (95% CI) of 26 (15–98), 24 (14–84), 20 (11–70), and 18 (10–77). The 5-year CIR (95% CI) was 4.8% (1.3–8.2%), 5.0% (1.3–8.7%), 6.1% (1.7–10.5%), and 7.7% (2.3–13.2%), respectively. Consistent results were obtained for 5-point MACE, additionally including coronary revascularization and unstable angina.

Conclusion

Among patients with ASCVD and elevated triglyceride levels, icosapent ethyl significantly reduces the risk of MACE irrespective of baseline CVD risk, though absolute benefits are largest for patients at the highest risk.