bluuebunny/crossref_metadata_2025 huggingface dataset:
Paraneoplastic Syndromes in Patients with Keratinocyte Skin Cancer
Authors: Vlachos Christoforos , Tziortzioti Chrysanthi , Bassukas Ioannis D.
Published: January 2022

A variety of well-characterized cutaneous paraneoplastic syndromes (PNS) are diagnosed during internal malignancies; however, the spectrum of keratinocyte skin neoplasms (KSC) related to PNS is still obscure. The aim of the present review is to compile and evaluate the literature data on PNS associated with a keratinocyte skin neoplasm (KSC). Employing Pubmed, MEDLINE was searched for KSC-associated PNS reports. Forty relevant entries were assembled, reporting a total of 41 PNS cases associated with a KSC (34 male). No review paper compiling this topic was found. Six distinct PNS entities were identified, and malignancy associated hypercalcemia (MAH; 78%), anemia (10%) and Bazex syndrome (5%) were the most frequently reported among them. 85% of the PNS were reported in association with SCC, 10% with BCC, and the rest with adnexal tumors. The median age of the patients at the time of PNS diagnosis was 58 years (range: five–83 years). In most cases the PNS was diagnosed either concurrently or after the KSC diagnosis. KSC predisposing conditions, as scars (22%) or hidradenitis suppurativa (20%), were reported in >70% of the PNS cases. Most PNS resolved after KSC treatment. In conclusion, PNS of a rather limited spectrum of entities are reported in association with KSC. They also seem to be rare, possibly reflecting a limited capacity of KSC to provoke overt PNS.
The Molecular Landscape of Medulloblastoma in Teenagers and Young Adults
Authors: Mohammed Omar J. , Cebrero Maria Estevez , Ahmad Omar , Peet Andrew , Grundy Richard G. , Lourdusamy Anbarasu
Published: January 2022

Medulloblastoma (MB) is a childhood malignant brain tumour but also occurs in teenagers and young adults (TYA). Considering that MB is heterogeneous, this study aimed to define the molecular landscape of MBs in TYAs. We collated more than 2000 MB samples that included 287 TYA patients (13–24 years). We performed computational analyses consisting of genome-wide methylation and transcriptomic profiles and developed a prognostics model for the TYAs with MB. We identified that TYAs predominantly comprised of Group 4 (40%) and Sonic Hedgehog (SHH)-activated (33%) tumours, with Wingless-type (WNT, 17%) and Group 3 (10%) being less common. TYAs with SHH tumours displayed significantly more gene expression alterations, whereas no gene was detected in the Group 4 tumours. Across MB subgroups, we identified unique and shared sets of TYA-specific differentially methylated probes and DNA-binding motifs. Finally, a 22-gene signature stratified TYA patients into high- and low-risk groups, and the prognostic significance of these risk groups persisted in multivariable regression models (P = 0.001). This study is an important step toward delineating the molecular landscape of TYAs with MB. The emergence of novel genes and pathways may provide a basis for improved clinical management of TYA with MB.
Machine Learning to Discern Interactive Clusters of Risk Factors for Late Recurrence of Metastatic Breast Cancer
Authors: Gomez Marti Juan Luis , Brufsky Adam , Wells Alan , Jiang Xia
Published: January 2022

Background: Risk of metastatic recurrence of breast cancer after initial diagnosis and treatment depends on the presence of a number of risk factors. Although most univariate risk factors have been identified using classical methods, machine-learning methods are also being used to tease out non-obvious contributors to a patient’s individual risk of developing late distant metastasis. Bayesian-network algorithms can identify not only risk factors but also interactions among these risks, which consequently may increase the risk of developing metastatic breast cancer. We proposed to apply a previously developed machine-learning method to discern risk factors of 5-, 10- and 15-year metastases. Methods: We applied a previously validated algorithm named the Markov Blanket and Interactive Risk Factor Learner (MBIL) to the electronic health record (EHR)-based Lynn Sage Database (LSDB) from the Lynn Sage Comprehensive Breast Center at Northwestern Memorial Hospital. This algorithm provided an output of both single and interactive risk factors of 5-, 10-, and 15-year metastases from the LSDB. We individually examined and interpreted the clinical relevance of these interactions based on years to metastasis and reliance on interactivity between risk factors. Results: We found that, with lower alpha values (low interactivity score), the prevalence of variables with an independent influence on long-term metastasis was higher (i.e., HER2, TNEG). As the value of alpha increased to 480, stronger interactions were needed to define clusters of factors that increased the risk of metastasis (i.e., ER, smoking, race, alcohol usage). Conclusion: MBIL identified single and interacting risk factors of metastatic breast cancer, many of which were supported by clinical evidence. These results strongly recommend the development of further large data studies with different databases to validate the degree to which some of these variables impact metastatic breast cancer in the long term.
Reliability of Alkaline Phosphatase for Differentiating Flare Phenomenon from Disease Progression with Bone Scintigraphy
Authors: Jung Ji-hoon , Hong Chae-Moon , Jo Il , Jeong Shin-Young , Lee Sang-Woo , Lee Jaetae , Ahn Byeong-Cheol
Published: January 2022

The flare phenomenon (FP) on bone scintigraphy after the initiation of systemic treatment seriously complicates evaluations of therapeutic response in patients with bone metastases. The aim of this study was to evaluate whether serum alkaline phosphatase (ALP) can differentiate FP from disease progression on bone scintigraphy in these patients. Breast or prostate cancer patients with bone metastases who newly underwent systemic therapy were reviewed. Pretreatment baseline and follow-up data, including age, pathologic factors, type of systemic therapy, radiologic and bone scintigraphy findings, and ALP levels, were obtained. Univariate and multivariate analyses of these factors were performed to predict FP. An increased extent and/or new lesions were found in 160 patients on follow-up bone scintigraphy after therapy. Among the 160 patients, 80 (50%) had an improvement on subsequent bone scintigraphy (BS), while subsequent scintigraphy also showed an increased uptake in 80 (50%, progression). Multiple regression analysis revealed that stable or decreased ALP was an independent predictor for FP (p < 0.0001). ALP was an independent predictor for FP on subgroup analysis for breast and prostate cancer (p = 0.001 and p = 0.0223, respectively). Results of the study suggest that ALP is a useful serologic marker to differentiate FP from disease progression on bone scintigraphy in patients with bone metastasis. Clinical interpretation for scintigraphic aggravation can be further improved by the ALP data and it may prevent fruitless changes of therapeutic modality by misdiagnosis of disease progression in cases of FP.
Blood-Derived Extracellular Vesicle-Associated miR-3182 Detects Non-Small Cell Lung Cancer Patients
Authors: Visan Kekoolani S. , Lobb Richard J. , Wen Shu Wen , Bedo Justin , Lima Luize G. , Krumeich Sophie , Palma Carlos , Ferguson Kaltin , Green Ben , Niland Colleen , Cloonan Nicole , Simpson Peter T. , McCart Reed Amy E. , Everitt Sarah J. , MacManus Michael P. , Hartel Gunter , Salomon Carlos , Lakhani Sunil R. , Fielding David , Möller Andreas
Published: January 2022

With five-year survival rates as low as 3%, lung cancer is the most common cause of cancer-related mortality worldwide. The severity of the disease at presentation is accredited to the lack of early detection capacities, resulting in the reliance on low-throughput diagnostic measures, such as tissue biopsy and imaging. Interest in the development and use of liquid biopsies has risen, due to non-invasive sample collection, and the depth of information it can provide on a disease. Small extracellular vesicles (sEVs) as viable liquid biopsies are of particular interest due to their potential as cancer biomarkers. To validate the use of sEVs as cancer biomarkers, we characterised cancer sEVs using miRNA sequencing analysis. We found that miRNA-3182 was highly enriched in sEVs derived from the blood of patients with invasive breast carcinoma and NSCLC. The enrichment of sEV miR-3182 was confirmed in oncogenic, transformed lung cells in comparison to isogenic, untransformed lung cells. Most importantly, miR-3182 can successfully distinguish early-stage NSCLC patients from those with benign lung conditions. Therefore, miR-3182 provides potential to be used for the detection of NSCLC in blood samples, which could result in earlier therapy and thus improved outcomes and survival for patients.
Onco-miR-21 Promotes Stat3-Dependent Gastric Cancer Progression
Authors: Tse Janson , Pierce Thomas , Carli Annalisa L. E. , Alorro Mariah G. , Thiem Stefan , Marcusson Eric G. , Ernst Matthias , Buchert Michael
Published: January 2022

MicroRNA-21 (miR-21) is a small, non-coding RNA overexpressed in gastric cancer and many other solid malignancies, where it exhibits both pro-and anti-tumourigenic properties. However, the pathways regulating miR-21 and the consequences of its inhibition in gastric cancer remain incompletely understood. By exploiting the spontaneous Stat3-dependent formation of inflammation-associated gastric tumors in Gp130F/F mice, we functionally established miR-21 as a Stat3-controlled driver of tumor growth and progression. We reconciled our discoveries by identifying several conserved Stat3 binding motifs upstream of the miR-21 gene promoter, and showed that the systemic administration of a miR-21-specific antisense oligonucleotide antagomir reduced the established gastric tumor burden in Gp130F/F mice. We molecularly delineated the therapeutic benefits of miR-21 inhibition with the functional restoration of PTEN in vitro and in vivo, alongside an attenuated epithelial-to-mesenchymal transition and the extracellular matrix remodeling phenotype of tumors. We corroborated our preclinical findings by correlating high STAT3 and miR-21 expression with the reduced survival probability of gastric cancer patients. Collectively, our results provide a molecular framework by which miR-21 mediates inflammation-associated gastric cancer progression, and establish miR-21 as a robust therapeutic target for solid malignancies characterized by excessive Stat3 activity.
Multifactorial Mechanism of Sarcopenia and Sarcopenic Obesity. Role of Physical Exercise, Microbiota and Myokines
Authors: Bilski Jan , Pierzchalski Piotr , Szczepanik Marian , Bonior Joanna , Zoladz Jerzy
Published: January 2022

Obesity and ageing place a tremendous strain on the global healthcare system. Age-related sarcopenia is characterized by decreased muscular strength, decreased muscle quantity, quality, and decreased functional performance. Sarcopenic obesity (SO) is a condition that combines sarcopenia and obesity and has a substantial influence on the older adults’ health. Because of the complicated pathophysiology, there are disagreements and challenges in identifying and diagnosing SO. Recently, it has become clear that dysbiosis may play a role in the onset and progression of sarcopenia and SO. Skeletal muscle secretes myokines during contraction, which play an important role in controlling muscle growth, function, and metabolic balance. Myokine dysfunction can cause and aggravate obesity, sarcopenia, and SO. The only ways to prevent and slow the progression of sarcopenia, particularly sarcopenic obesity, are physical activity and correct nutritional support. While exercise cannot completely prevent sarcopenia and age-related loss in muscular function, it can certainly delay development and slow down the rate of sarcopenia. The purpose of this review was to discuss potential pathways to muscle deterioration in obese individuals. We also want to present the current understanding of the role of various factors, including microbiota and myokines, in the process of sarcopenia and SO.
Cell Type-Selective Loss of Peroxisomal β-Oxidation Impairs Bipolar Cell but Not Photoreceptor Survival in the Retina
Authors: Swinkels Daniëlle , Das Yannick , Kocherlakota Sai , Vinckier Stefan , Wever Eric , van Kampen Antoine H.C. , Vaz Frédéric M. , Baes Myriam
Published: January 2022

Retinal degeneration is a common feature in peroxisomal disorders leading to blindness. Peroxisomes are present in the different cell types of the retina; however, their precise contribution to retinal integrity is still unclear. We previously showed that mice lacking the central peroxisomal β-oxidation enzyme, multifunctional protein 2 (MFP2), develop an early onset retinal decay including photoreceptor cell death. To decipher the function of peroxisomal β-oxidation in photoreceptors, we generated cell type selective Mfp2 knockout mice, using the Crx promotor targeting photoreceptors and bipolar cells. Surprisingly, Crx-Mfp2−/− mice maintained photoreceptor length and number until the age of 1 year. A negative electroretinogram was indicative of preserved photoreceptor phototransduction, but impaired downstream bipolar cell signaling from the age of 6 months. The photoreceptor ribbon synapse was affected, containing free-floating ribbons and vesicles with altered size and density. The bipolar cell interneurons sprouted into the ONL and died. Whereas docosahexaenoic acid levels were normal in the neural retina, levels of lipids containing very long chain polyunsaturated fatty acids were highly increased. Crx-Pex5−/− mice, in which all peroxisomal functions are inactivated in photoreceptors and bipolar cells, developed the same phenotype as Crx-Mfp2−/− mice. In conclusion, the early photoreceptor death in global Mfp2−/− mice is not driven cell autonomously. However, peroxisomal β-oxidation is essential for the integrity of photoreceptor ribbon synapses and of bipolar cells.
Role and Involvement of TENM4 and miR-708 in Breast Cancer Development and Therapy
Authors: Peppino Giulia , Riccardo Federica , Arigoni Maddalena , Bolli Elisabetta , Barutello Giuseppina , Cavallo Federica , Quaglino Elena
Published: January 2022

Teneurin 4 (TENM4) is a transmembrane protein that is codified by the ODZ4 gene and is involved in nervous system development, neurite outgrowth, and neuronal differentiation. In line with its involvement in the nervous system, TENM4 has also been implicated in several mental disorders such as bipolar disorder, schizophrenia, and autism. TENM4 mutations and rearrangements have recently been identified in a number of tumors. This, combined with impaired expression in tumors, suggests that it may potentially be involved in tumorigenesis. Most of the TENM4 mutations that are observed in tumors occur in breast cancer, in which TENM4 plays a role in cells’ migration and stemness. However, the functional role that TENM4 plays in breast cancer still needs to be better evaluated, and further studies are required to better understand the involvement of TENM4 in breast cancer progression. Herein, we review the currently available data for TENM4′s role in breast cancer and propose its use as both a novel target with which to ameliorate patient prognosis and as a potential biomarker. Moreover, we also report data on the tumorigenic role of miR-708 deregulation and the possible use of this miRNA as a novel therapeutic molecule, as miR-708 is spliced out from TENM4 mRNA.
Targeting PGM3 as a Novel Therapeutic Strategy in KRAS/LKB1 Co-Mutant Lung Cancer
Authors: Lee Hyunmin , Cai Feng , Kelekar Neil , Velupally Nipun K. , Kim Jiyeon
Published: January 2022

In non-small-cell lung cancer (NSCLC), concurrent mutations in the oncogene KRAS and tumor suppressor STK11 (also known as LKB1) confer an aggressive malignant phenotype, an unfavourability towards immunotherapy, and overall poor prognoses in patients. In a previous study, we showed that murine KRAS/LKB1 co-mutant tumors and human co-mutant cancer cells have an enhanced dependence on glutamine-fructose-6-phosphate transaminase 2 (GFPT2), a rate-limiting enzyme in the hexosamine biosynthesis pathway (HBP), which could be targeted to reduce survival of KRAS/LKB1 co-mutants. Here, we found that KRAS/LKB1 co-mutant cells also exhibit an increased dependence on N-acetylglucosamine-phosphate mutase 3 (PGM3), an enzyme downstream of GFPT2. Genetic or pharmacologic suppression of PGM3 reduced KRAS/LKB1 co-mutant tumor growth in both in vitro and in vivo settings. Our results define an additional metabolic vulnerability in KRAS/LKB1 co-mutant tumors to the HBP and provide a rationale for targeting PGM3 in this aggressive subtype of NSCLC.
Isolation and Propagation of Human Corneal Stromal Keratocytes for Tissue Engineering and Cell Therapy
Authors: binte M. Yusoff Nur Zahirah , Riau Andri K. , Yam Gary H. F. , binte Halim Nuur Shahinda Humaira , Mehta Jodhbir S.
Published: January 2022

The human corneal stroma contains corneal stromal keratocytes (CSKs) that synthesize and deposit collagens and keratan sulfate proteoglycans into the stromal matrix to maintain the corneal structural integrity and transparency. In adult corneas, CSKs are quiescent and arrested in the G0 phase of the cell cycle. Following injury, some CSKs undergo apoptosis, whereas the surviving cells are activated to become stromal fibroblasts (SFs) and myofibroblasts (MyoFBs), as a natural mechanism of wound healing. The SFs and MyoFBs secrete abnormal extracellular matrix proteins, leading to corneal fibrosis and scar formation (corneal opacification). The issue is compounded by the fact that CSK transformation into SFs or MyoFBs is irreversible in vivo, which leads to chronic opacification. In this scenario, corneal transplantation is the only recourse. The application of cell therapy by replenishing CSKs, propagated in vitro, in the injured corneas has been demonstrated to be efficacious in resolving early-onset corneal opacification. However, expanding CSKs is challenging and has been the limiting factor for the application in corneal tissue engineering and cell therapy. The supplementation of serum in the culture medium promotes cell division but inevitably converts the CSKs into SFs. Similar to the in vivo conditions, the transformation is irreversible, even when the SF culture is switched to a serum-free medium. In the current article, we present a detailed protocol on the isolation and propagation of bona fide human CSKs and the morphological and genotypic differences from SFs.
Metabolic Implications of Immune Checkpoint Proteins in Cancer
Authors: Stirling Elizabeth R. , Bronson Steven M. , Mackert Jessica D. , Cook Katherine L. , Triozzi Pierre L. , Soto-Pantoja David R.
Published: January 2022

Expression of immune checkpoint proteins restrict immunosurveillance in the tumor microenvironment; thus, FDA-approved checkpoint inhibitor drugs, specifically PD-1/PD-L1 and CTLA-4 inhibitors, promote a cytotoxic antitumor immune response. Aside from inflammatory signaling, immune checkpoint proteins invoke metabolic reprogramming that affects immune cell function, autonomous cancer cell bioenergetics, and patient response. Therefore, this review will focus on the metabolic alterations in immune and cancer cells regulated by currently approved immune checkpoint target proteins and the effect of costimulatory receptor signaling on immunometabolism. Additionally, we explore how diet and the microbiome impact immune checkpoint blockade therapy response. The metabolic reprogramming caused by targeting these proteins is essential in understanding immune-related adverse events and therapeutic resistance. This can provide valuable information for potential biomarkers or combination therapy strategies targeting metabolic pathways with immune checkpoint blockade to enhance patient response.
Factor Structure of the AUDIM-M Dimensional Self-Concept Questionnaire in Mexican Adolescents
Authors: Blanco José René , Ornelas Martha , Barrón-Luján Juan Cristóbal , Franco-Gallegos Leticia Irene , Aguirre Susana Ivonne , Blanco Humberto , Zueck María del Carmen , Jurado-García Perla Jannet
Published: January 2022

Self-concept is one of the most relevant variables in the field of personality, and a negative self-perception can pose a risk to the adolescent’s development. The present study aimed to analyze the psychometric properties proposed by Aguirre and collaborators for the dimensional self-concept questionnaire (AUDIM-M). The total sample was 560 adolescents from the city of Chihuahua, Chihuahua, with a mean age of 12.96 ± 0.88 years. The factor structure of the questionnaire was analyzed using confirmatory factor analysis. The analyses show that a four-factor structure is viable and adequate (GFI 0.964; RMSEA 0.057; CFI 0.950). The four-factor structure (personal self-concept, physical self-concept, social self-concept, and academic self-concept), according to statistical and substantive criteria, shows adequate indicators of reliability and validity adjustment. The model obtained coincides with that proposed by Aguirre et al. Improving adolescents’ self-concept undoubtedly contributes to their quality of life, hence the need for valid and reliable instruments for its measurement; this study could be a first approach for future research.
Validation of a Computerized Version of the Trait Subscale of the Physical Appearance State and Trait Anxiety Scale in Mexican Preadolescents
Authors: Aguirre Juan Francisco , Rangel-Ledezma Yunuen Socorro , Jurado-García Perla Jannet , Blanco Humberto , Ornelas Martha , Jiménez-Lira Carolina , Blanco José René , Aguirre Susana Ivonne
Published: January 2022

Anxiety is a feeling of fear, dread or restlessness and can develop into a weight-related disorder. The objective was to analyze the psychometric properties of the trait anxiety subscale of the Physical Appearance State and Trait Anxiety Scale (PASTAS), as well as the invariance in Mexican preadolescents. The sample consisted of 604 participants, 285 female and 319 male, whose ages ranged between 11 and 12 years (M = 11.37; SD = 0.48). The questionnaire’s factor structure was analyzed using confirmatory factor analyses. The analyses show the viability and adequacy of a two-factor structure (weight and non-weight factors) both for the total sample and for the populations of male and female. The two-factor structure showed adequate reliability and validity fit indicators. The factor structure, the factor loadings and intercepts are considered invariant according to the variable sex; however, differences between female and male participants were found for levels of anxiety caused by physical appearance. In conclusion, the PASTAS can be considered a convenient instrument to assess the variables related to anxiety generated by one’s physical appearance, as well as allowing more participants to be quickly assessed.
Associations of Motor Performance and Executive Functions: Comparing Children with Down Syndrome to Chronological and Mental Age-Matched Controls
Authors: Klotzbier Thomas Jürgen , Holfelder Benjamin , Schott Nadja
Published: January 2022

Background. Children with Down syndrome (DS) exhibit lower motor and cognitive performance than typically developing children (TD). Although there is a relationship between these two developmental domains, only a few studies have addressed this association in children with DS compared to groups of the same chronological age (CA) or mental age (MA) within one study. This study aimed to fill this research gap. Method and Procedures. The Movement Assessment Battery for Children-2 and the Trail-Making Test was used to assess motor and cognitive performances in 12 children (M = 10.5 ± 10.08) with DS, 12 CA-matched, and 12 MA-matched controls. Results. There are significant group differences in the motor dimension (total test score; p < 0.001, η2p = 0.734), for processing speed (p < 0.001, η2p = 0.396), and cognitive flexibility (p < 0.001, η2p = 0.498). Between TD-CA and both other groups, the differences in the magnitude of correlations for the motor dimension balance are also significant (compared to DS: z = −2.489; p = 0.006, and to TD-MA: z = −3.12; p < 0.001). Conclusions. Our results suggest that the relationships depend on the studied cognitive and motor skills. It seems crucial to select a wide range of tasks for both domains that are as isolated as possible for future studies, to better understand the relationships between cognitive and motor skills in children with DS.
Video-Assisted Thoracoscopy for Vertebral Body Tethering of Juvenile and Adolescent Idiopathic Scoliosis: Tips and Tricks of Surgical Multidisciplinary Management
Authors: Costanzo Sara , Pansini Andrea , Colombo Luca , Caretti Valentina , Popovic Petar , Lanfranchi Giulia , Camporesi Anna , Pelizzo Gloria
Published: January 2022

VATS (video assisted thoracoscopic surgery) is routinely and successfully performed in minor and major complex thoracic procedures. This technique has been recently introduced for the treatment of severe forms of idiopathic scoliosis (IS) with the aim to repair the deformity, reduce morbidity and to prevent its progression in patients with skeletal immaturity. This study aims to present VATS in anterior vertebral body tethering (AVBT) approach to support the pediatric orthopedic surgeons during vertebral body fixation. Surgical and anesthesiologic tips and tricks are reported to assure a safe procedure. The study includes preadolescents with IS and a grade of scoliosis >40° that had a high probability of deterioration due to remaining growth (December 2018 to April 2021). Skeletal immaturity of enrolled patients was assessed by Sanders classification and Risser sign. Patients had a Risser score between 0 and 1 and a Sanders score >2 and <5. AVBT technique using VATS was performed by a senior pediatric surgeon assisting the pediatric orthopedic surgeon. Twenty-three patients have been submitted to VATS AVBT in the period of study (age range 9–14 years). The patients had a classified deformity Lenke 1A or B convex right and all types of curves were treated. In all patients, the vertebrae submitted to tethering surgery ranged from D5 to D12; mean curve correction was 43%. Three postoperative complications occurred: one late postoperative bleeding requiring a chest tube positioning on 12th postoperative day; one screw dislodged and needed to be removed; one child showed worsening of the scoliosis and needed a posterior arthrodesis. Initial results of VATS AVBT in growing patients with spinal deformities are encouraging. An appropriate selection of patients and a pediatric dedicated multidisciplinary surgical approach decrease intraoperative complications, time of operation and postoperative sequelae and guarantee an optimal outcome.
Patellar Osteomyelitis in a 9-Year-Old Patient with Chronic Granulomatous Disease: A Case Report
Authors: Park Yonggeun , Yoo Seungjin , Chu Yongyeon , Lim Chaemoon
Published: January 2022

Hematogenous osteomyelitis is commonly reported in long tubular bones in the pediatric population. Acute osteomyelitis involving the patella is extremely uncommon in children, and its diagnosis is frequently delayed due to its rarity and variable clinical manifestations. Chronic granulomatous disease (CGD) is a rare genetic immunodeficiency disorder characterized by severe recurrent bacterial and fungal infections. The most commonly affected sites of infection are the lungs, lymph nodes, skin, liver, and gastrointestinal tract. Acute hematogenous osteomyelitis of the patella associated with CGD has never been reported. Our report describes the first case of acute hematogenous patellar osteomyelitis in a pediatric patient with CGD. Her clinical manifestations were similar to other possible differentials such as septic arthritis; however, use of advanced imaging confirmed the diagnosis, and the patient was successfully managed surgically. Since hematogenous osteomyelitis in children is uncommon, a high index of suspicion and advanced imaging may help with its diagnosis, and in cases where antibiotic treatment proves to be insufficient, prompt surgical management is imperative.
Growth of Very Preterm Infants in a Low-Resourced Rural Setting after Affiliation with a Human Milk Bank
Authors: Chen Chia-Huei , Chiu Hui-Ya , Lee Szu-Chia , Chang Hung-Yang , Chang Jui-Hsing , Chen Yen-Ju , Kang Lin , Shen Shang-Po , Lin Yung-Chieh
Published: January 2022

The extrauterine growth restriction (EUGR) of very preterm infants has been associated with long-term complications and neurodevelopmental problems. EUGR has been reported at higher rates in low resource settings. There is limited research investigating how metropolitan human milk banks contribute to the growth outcomes of very preterm infants cared in rural areas. The setting of this study is located at a rural county in Taiwan and affiliated with the Taiwan Southern Human Milk Bank. Donor human milk was provided through a novel supplemental system. A renewal nutritional protocol was initiated as a quality improvement project after the affiliated program. This study aimed to compare the clinical morbidities and growth outcome at term equivalent age (TEA) of preterm infants less than 33 weeks of gestational age before (Epoch-I, July 2015–June 2018, n = 40) and after the new implementation (Epoch-II, July 2018–December 2020, n = 42). The Epoch-II group significantly increased in bodyweight z-score at TEA ((−0.02 ± 1.00) versus Epoch-I group (−0.84 ± 1.08), p = 0.002). In multivariate regression models, the statistical difference between two epochs in bodyweight z-score changes from birth to TEA was still noted. Modern human milk banks may facilitate the nutritional protocol renewal in rural areas and improve the growth outcomes of very preterm infants cared for. Establishing more distribution sites of milk banks should be encouraged.
Factors Influencing the Progression and Direction of Scoliosis in Children with Neurological Disorders
Authors: Yoo Yeun-Jie , Park Jung-Geun , Jo Leechan , Hwang Youngdeok , Yoon Mi-Jeong , Kim Joon-Sung , Lim Seonghoon , Hong Bo-Young
Published: January 2022

(1) Background: scoliosis is highly prevalent in children with neurological disorders, however, studies predicting the progression and affecting the direction of scoliosis have been insufficient. We investigated the factors associated with the progression and direction of scoliosis in children with neurological disorders. (2) Method: retrospectively, 518 whole spine radiographs from 116 patients were used for analysis. Factors affecting the progression of scoliosis over time were analyzed using linear mixed-effects model. Factors associated with the apex direction of the scoliosis were analyzed. (3) Results: pelvic obliquity (PO) ≥ 2.5°, gross motor function classification system level V, vertebral rotation, and female sex significantly affect the progression of scoliosis (p = 0.04, <0.001, <0.001, 0.005, respectively). The higher side of PO and the apex side of scoliosis were interrelated (χ² = 14.58, p < 0.001), but the asymmetrical neurological upper extremity involvement was not. (4) Conclusions: severely impaired gross motor function, PO, vertebral rotation, and female sex were significantly related to the progression of scoliosis. The higher side of PO was opposite to the apex side of scoliosis. By identifying the factors that influence the progression of scoliosis, patients at high risk could be more actively intervened to minimize the severe complications.
Effect of Cerium and Magnesium on Surface Microcracks of Al–20Si Alloys Induced by High-Current Pulsed Electron Beam
Authors: Hu Liang , Gao Bo , Xu Ning , Sun Yue , Zhang Ying , Xing Pengfei
Published: January 2022

The effect of Ce and Mg on surface microcracks of Al–20Si alloys induced via high-current pulsed electron beam (HCPEB) was studied. Mg was revealed to refine the primary Si phase in the pristine microstructure by forming a Mg2Si phase, leading to the suppression of microcrack propagation within the brittle phase after HCPEB irradiation. The incorporation of Ce into the Al–Si–Mg alloys further refined the primary Si phase and reduced the local stress concentration in the brittle phase induced by HCPEB irradiation. Ultimately, the surface microcracks were observed to be eliminated by the synergistic effects between the two elements. For Al–20Si–5Mg–0.7Ce alloys, Ce demonstrated a homogeneous distribution in the Al matrix on the HCPEB-irradiated alloy surface, while the Mg and Si exhibited a certain degree of aggregation in the Mg2Si phase. Metastable structures were formed on the HCPEB-irradiated alloy surface, including the nano-primary silicon phase, nano-cellular aluminium structure, and nano-Mg2Si phase. Compared with alloy specimens containing Mg, the Al–20Si–5Mg–0.7Ce alloy specimens exhibited an excellent anticorrosion property after HCPEB irradiation mainly due to the combined effects of the grain refinement and microcrack elimination.
Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients
Authors: Cerulli Antonietta , Masullo Milena , Montoro Paola , Piacente Sonia
Published: January 2022

The interest in plant extracts and natural compounds in cosmetic formulations is growing. Natural products may significantly improve cosmetics performance since they have both cosmetic and therapeutic-like properties, known as cosmeceutical effects. Glycyrrhiza genus, belonging to the Leguminosae family, comprises more than 30 species, widely distributed worldwide. The rhizomes and roots are the most important medicinal parts currently used in pharmaceutical industries and in the production of functional foods and food supplements. In the last few years, the interest in their potential activities in cosmetic formulations has greatly increased. Glycyrrhiza spp. extracts are widely implemented in cosmetic products for their good whitening effect. The biological effects of Glycyrrhiza extracts are especially ascribable to the occurrence of specialized metabolites belonging to the flavonoid class. This review focuses on the botany and the chemistry of the main investigated Glycyrrhiza spp. (G. glabra, G. uralensis, and G. inflata) along with their cosmeceutical activities categorized as skin anti-aging, photoprotective, hair care, and anti-acne. It has been highlighted how, along with Glycyrrhiza extracts, three main flavonoids namely licochalcone A, glabridin, and dehydroglyasperin C are the most investigated compounds. It is noteworthy that other molecules from licorice show potential cosmeceutical effects. These data suggest further investigations to clarify their potential value for cosmetic industries.
Shear Wave Elastography and Thyroid Imaging Reporting and Data System (TIRADS) for the Risk Stratification of Thyroid Nodules—Results of a Prospective Study
Authors: Petersen Manuela , Schenke Simone A. , Firla Jonas , Croner Roland S. , Kreissl Michael C.
Published: January 2022

Purpose: To compare the diagnostic performance of thyroid imaging reporting and data system (TIRADS) in combination with shear wave elastography (SWE) for the assessment of thyroid nodules. Methods: A prospective study was conducted with the following inclusion criteria: preoperative B-mode ultrasound (US) including TIRADS classification (Kwak-TIRADS, EU-TIRADS), quantitative SWE and available histological results. Results: Out of 43 patients, 61 thyroid nodules were detected; 10 nodules were found to be thyroid cancer (7 PTC, 1 FTC, 2 HüCC) and 51 were benign. According to Kwak-TIRADS the majority of benign nodules (47 out of 51, 92.2%) were classified in the low-risk- and intermediate-risk class, four nodules were classified as high-risk (7.8%). When using EU-TIRADS, the benign nodules were distributed almost equally across all risk classes, 21 (41.2%) nodules were classified in the low-risk class, 16 (31.4%) in the intermediate-risk class and 14 (27.4%) in the high-risk class. In contrast, most of the malignant nodules (eight out of ten) were classified as high-risk on EU-TIRADS. One carcinoma was classified as low-risk and one as intermediate-risk nodule. For SWE, ROC analysis showed an optimal cutoff of 18.5 kPa to distinguish malignant and benign nodules (sensitivity 80.0%, specificity 49.0%, PPV 23.5% and NPV 92.6%). The addition of elastography resulted in an increase of accuracy from 65.6% to 82.0% when using Kwak-TIRADS and from 49.2% to 72.1% when using EU-TIRADS. Conclusion: Our data demonstrate that the combination of TIRADS and SWE seems to be superior for the risk stratification of thyroid nodules than each method by itself. However, verification of these results in a larger patient population is mandatory.
Classical-Quantum Transition as a Disorder-Order Process
Authors: Kowalski Andres M. , Plastino Angelo
Published: January 2022

We associate here the relationship between de-coherence to the statistical notion of disequilibrium with regards to the dynamics of a system that reflects the interaction between matter and a given field. The process is described via information geometry. Some of its tools are shown here to appropriately explain the process’ mechanism. In particular we gain some insight into what is the role of the uncertainty principle (UP) in the pertinent proceedings.
Archetypal Analysis and DEA Model, Their Application on Financial Data and Visualization with PHATE
Authors: Grzybowska Urszula , Karwański Marek
Published: January 2022

One of the goals of macroeconomic analysis is to rank and segment enterprises described by many financial indicators. The segmentation can be used for investment strategies or risk evaluation. The aim of this research was to distinguish groups of similar objects and visualize the results in a low dimensional space. In order to obtain clusters of similar objects, the authors applied a DEA BCC model and archetypal analysis for a set of companies described by financial indicators and listed on the Warsaw Stock Exchange. The authors showed that both methods give consistent results. To get a better insight into the data structure as well as a visualization of the similarities between objects, the authors used a new approach called the PHATE algorithm. It allowed the results of DEA and archetypal analysis to be visualized in a low dimensional space.
Dhaka Sitting on a Plastic Bomb: Issues and Concerns around Waste Governance, Water Quality, and Public Health
Authors: Nadiruzzaman Md , Shewly Hosna Jahan , Esha Afsana Afrin
Published: January 2022

Plastic, an offer of modernity, has become one of the essential parts of our everyday life. However, it is presenting a massive threat in altered forms, to our health and environment. Plastic does not only pollute the surface environment, freshwater, and marine ecosystems, but toxic elements released from plastics also percolate down the surface and contaminate groundwater, which we often use as ‘safe’ drinking water. This probable future risk is deeply rooted in the entire governance infrastructure of plastic waste which could potentially lead to contamination of groundwater. Thus, a state-sponsored ‘safe drinking water’ initiative could contrarily produce a ‘risk society’. A recent study finds 81% of tap water samples collected worldwide contained plastic pollutants, which means that annually we may be ingesting between 3000 and 4000 microparticles of plastic from tap water. Based on review, ethnographic observations and interviews, and lived experience in a plastic-wrapped city (Dhaka), this paper sheds light on the complex interface of plastic, water, and public health, on the relevance of Beck’s ‘risk society’ to understand this complexity, and on replicating the idea of ‘risk society’ in the case of Bangladesh. Through understanding the plastic–groundwater–waste management nexus, this paper highlights and advocates for a new strategy of plastic governance in modern states.
Forecasting Real GDP Growth for Africa
Authors: Franses Philip Hans , Welz Max
Published: January 2022

We propose a simple and reproducible methodology to create a single equation forecasting model (SEFM) for low-frequency macroeconomic variables. Our methodology is illustrated by forecasting annual real GDP growth rates for 52 African countries, where the data are obtained from the World Bank and start in 1960. The models include lagged growth rates of other countries, as well as a cointegration relationship to capture potential common stochastic trends. With a few selection steps, our methodology quickly arrives at a reasonably small forecasting model per country. Compared with benchmark models, the single equation forecasting models seem to perform quite well.
Uncovering Hidden Factors in Electricity Consumption Based on Gaussian Mixture Estimation
Authors: Liao Shiwen , Wei Lu , Su Wencong
Published: January 2022

Load characteristics play an essential role in the planning of power generation and distribution. Various undiscovered factors, which could be socioeconomic, geographic, or climatic, make it possible to describe the electricity demand by a multimodal distribution. This letter proposes a novel method based on multimodal distributions to characterize the hidden factors in electricity consumption. Consequently, a new approach is developed to evaluate the impact of the underlying factors of electricity consumption. Some quantifiable and predictable factors are analyzed in developing multimodal distribution to describe the expected demand. Simulations based on synthetic and real-world data have been conducted to demonstrate the usefulness and robustness of the proposed method.
Three-Dimensional Computation Fluid Dynamics Simulation of CO Methanation Reactor with Immersed Tubes
Authors: Sun Liyan , Lin Junjie , Kong Dali , Luo Kun , Fan Jianren
Published: January 2022

CO methanation is an exothermic process, and heat removal is an essential issue for the methanation reactor. Numerical studies were carried out to investigate the performance of a 3D fluidized bed methanation reactor with immersed cooling tubes. The simulations were carried out in the frame of the Euler–Euler model to analyze the performance of the reactor. The influences of operating temperatures were studied to understand the reaction characteristics. The temperature increases rapidly neared the inlet due to the reactions. The immersed tubes were effective at removing the reaction heat. The chemical equilibrium state was achieved with an operating temperature of 682 K for the case with immersed tubes. Different control mechanisms can be found during the process of increasing and decreasing the temperature. The reaction kinetic is the dominate factor for the cases with lower temperatures, while the chemical equilibrium will play a more important role at high temperature conditions. The configuration with staggered tubes is beneficial for heat removal.
Impact of Economic Affluence on CO2 Emissions in CEE Countries
Authors: Majewska Agnieszka , Gierałtowska Urszula
Published: January 2022

There is huge evidence for a relationship between economic growth and environmental degradation. One of the causes of environmental degradation is CO2 emission which is added to the atmosphere through human activities and excessive industrialization. The aim of this research is to examine the relationship between CO2 emissions and measures of wealth in countries of Central and Eastern Europe between 2000 and 2019. The paper extends the research on economic affluence by taking into consideration two measures of economic growth, in addition to GDP, the HDI index is included. The basis for the investigation is the EKC concept. All analyses are based on econometric models with GDP and the HDI index as independent variables. The results are not conclusive and there is no one model which best describes the relationship between CO2 emissions and economic growth. Verification of the models indicates the better fit of models with the HDI index as the measure of affluence. Moreover, the study confirms that the key factors affecting CO2 emissions are energy consumption per capita which leads to an increase in CO2 emissions, and renewable energy consumption which reduces CO2 emissions. Therefore, technological changes and an increase in human awareness of global sustainability are required.
A Mobile Robot-Based System for Automatic Inspection of Belt Conveyors in Mining Industry
Authors: Szrek Jarosław , Jakubiak Janusz , Zimroz Radoslaw
Published: January 2022

Mechanical systems (as belt conveyors) used in the mining industry, especially in deep underground mines, must be supervised on a regular basis. Unfortunately, they require high power and are spatially distributed over a large area. Till now, some elements of the conveyor (drive units) have been monitored 24 h/day using SCADA systems. The rest of the conveyor is inspected by maintenance staff. To minimize the presence of humans in harsh environments, we propose a mobile inspection platform based on autonomous UGV. It is equipped with various sensors, and in practice it is capable of collecting almost the same information as maintenance inspectors (RGB image, sound, gas sensor, etc.). Till now such experiments have been performed in the lab or in the mine, but the robot was controlled by the operator. In such a scenario the robot is able to record data, process them and detect, for example, an overheated idler. In this paper we will introduce the general concept of an automatic robot-based inspection for underground mining applications. A framework of how to deploy the inspection robot for automatic inspection (3D model of the tunnel, path planing, etc.) are defined and some first results from automatic inspection tested in lab conditions are presented. Differences between the planned and actual path are evaluated. We also point out some challenges for further research.
An Assessment of the Key Performance Indicators (KPIs) of Energy Efficient Retrofits to Existing Residential Buildings
Authors: McGinley Orlaith , Moran Paul , Goggins Jamie
Published: January 2022

Quantifying the wider benefits of energy efficient building retrofits is crucial to incentivise householder retrofit investments. This research recognises the value of key performance indicators (KPIs) for assessing and demonstrating retrofitting benefits and provides an assessment of KPIs for evaluating retrofits. An integrated framework for evaluating retrofits using a set of economic, social, and environmental KPIs is proposed. This KPI framework is then applied in a pre- and post-retrofit assessment of five case study dwellings located in Ireland, revealing its usefulness in demonstrating the wider benefits of retrofitting to householders, with a view to driving retrofit investment. Three of these case study dwellings had state-of-the-art retrofit technologies installed as part of the works, including heat pumps and solar PV systems. In addition to demonstrating the wider benefits of retrofitting, the framework allowed for the identification of potential causes for differences in performance of these technologies across households, as well as patterns of underperformance. Such insights are useful for the future design of these technologies and retrofit packages, as well as policy measures, which support householders in the adoption and use of these measures. The results demonstrate that householders experience various benefits from retrofitting. Showcasing the different benefits that householders receive from retrofitting, and their satisfaction with the retrofit works, can serve to de-risk retrofit investments, and inspire others to seek similar benefits through retrofitting. Applying the developed framework to a larger, comparable sample size, can distinguish the retrofit packages, which perform best across the KPIs and various household profiles. Furthermore, the application of the developed framework can serve as an evidence base for retrofit designers, contractors, and policy makers in the design of retrofit packages and policy measures that will maximise the benefit for householders.