bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the Implementation of a Home-Based Exercise Training Program for People With COPD: A Mixed-Methods Study
Authors: Cerini Tamara , Kunz Ramona , Dalla Lana Kaba , Radtke Thomas , Polhemus Ashley , Puhan Milo A. , Frei Anja
Published: October 2021

Introduction: Recently, we developed a home-based, minimal-equipment exercise training program HOMEX for people with chronic obstructive pulmonary disease (COPD) and tested its effectiveness over 1 year in a randomized controlled trial. The aims of the current study were to evaluate the implementation of HOMEX from the perspectives of all involved persons and to optimize the program to ensure its long-term sustainability.

Methods: In this mixed-methods study, we used qualitative and quantitative approaches to evaluate the implementation of the intervention on the level of patients with COPD and coaches who provided the intervention and relevant stakeholders. To assess the implementation outcomes dose, reach, fidelity, and adherence, we summarized information recorded in the notes of the coaches and the diaries of patients, complemented with results from qualitative assessments. To assess acceptability and appropriateness, we conducted surveys with patients and coaches, and semistructured interviews with selected patients, coaches, and stakeholders.

Results: The coaches delivered the three home visits with one exception according to the protocol (fidelity). Of the 53 intervention group participants, 37 (70%) conducted HOMEX training until the end of the study and 43 (79%) trained for at least 10 months. The exercise behaviors of the participants could be separated into the phases “Starting the training and stabilizing into regular training routine” and “Managing training disruptions” (adherence). Overall, patients, coaches, and stakeholders conveyed a very high “acceptability” of HOMEX, noting the home-based aspect as a particular strength and interaction with other patients as future need. All involved groups perceived the strength-training exercises as appropriate, efficient for people with COPD, and relevant to maintain improvements after pulmonary rehabilitation. The most important facilitators of the patients for long-term motivation were self-perceived improvement in strength, supervision by a coach, and integration of the training in daily routine. Based on these insights, we redesigned and reworded the exercise cards, introduced three new exercises, and refined the training book.

Discussion: The results of this study provided insights of the involved persons in the frame of the HOMEX intervention implementation with a particular focus on the long-term training behavior of the participants and their perception and experience with the exercise program. These findings enabled us to optimize the training material and adapt the structure of the program for sustainable further use in clinical and other settings.
Public Perceptions of Urban Green Spaces: Convergences and Divergences
Authors: Atiqul Haq Shah Md. , Islam Mohammad Nazrul , Siddhanta Ankita , Ahmed Khandaker Jafor , Chowdhury Mohammed Thanvir Ahmed
Published: October 2021

In the context of rapid climate change, it is important to understand public perceptions of urban green spaces (UGSs), because green spaces have enormous potential as instruments for climate change adaptation and mitigation, and because the development of such spaces both requires and benefits from public support. This article attempts, through an extensive literature review, to understand convergences and divergences in perceptions of urban green spaces (UGSs) of city dwellers around the world and to identify gaps in the existing research. Additionally, the article explores research into the benefits associated with urban green spaces, including health (e.g., physical and mental), social (e.g., social networks and social relationships), economic (e.g., employment and income generation), and environmental (e.g., ecosystem services and biodiversity). This article further seeks to identify the extent to which urban residents have been found to perceive the roles UGSs can play in climate change adaptation and mitigation, and cultural exchange. Based on studies conducted in different countries over the past decade, this paper integrates environmental, social, cultural, and economic aspects of urban greening to provide insight into the similarities and differences in perceptions of urban green spaces and suggest approaches to building climate change resilient urban communities. This paper finds justification for: encouraging the use of integrated, multidisciplinary approaches, using innovative tools, for both the study and practical development of UGSs; conducting a greater number of studies of newer urban areas in developing countries; and considering the diverse disadvantages as well as the advantages of UGSs in order to support the continued development and expansion of this critical climate-friendly infrastructure. The more that residents' perceptions of and attitudes toward UGSs are incorporated into the design of such spaces, the more successful they will be at providing the myriad benefits they have the potential to offer.
“This Is Not Gym”: Enacting Student Voice Pedagogies to Promote Social and Emotional Learning and Meaningful Physical Education
Authors: Howley Donal , Dyson Ben , Baek Seunghyun , Fowler Judy , Shen Yanhua
Published: October 2021

The purpose of this study was to explore learners' experiences enacting youth/student voice pedagogies (SVP) to promote Social and Emotional Learning (SEL) and meaningful physical education (MPE) in an alternative education setting. Drawing on social constructivist learning theory in understanding and implementing a MPE approach, and a systemic framework for SEL, two research questions guided the research process: (1) How did students interpret and enact these pedagogies? (2) What contribution did the enactment of these pedagogies have in promoting SEL and MPE? This study implemented a qualitative case study design framed by a participatory action research (PAR) approach spanning 12 weeks from February to May 2021. Participants in this study included 16 ninth grade alternative high school students (eight girls/eight boys) aged 14–15 who had just returned to face-to-face learning in January 2021 for the first time following COVID-19. A range of traditional and innovative participatory qualitative research methods including focus group interviews, students' personal biographies, timelines, digital and written reflections, photovoice, and class artifacts were utilized. TheMiles, Huberman, and Saldana Framework for Qualitative Data Analysiswas implemented involving both deductive and inductive combinations of comparative and thematic analysis. The following themes were constructed:Making responsible decisions; unearthing and sharing mixed emotions; picturing physical activity beyond the classroom; recognizing the role of relationships; considering challenge and competence;and,pursuing meaning. Findings demonstrate how enacting SVP can lead to the development of students' SEL and MPE experiences complimenting multiple learning domains. We call for further embedding of SVP capturing students' physical activity and movement experiences inside and outside of PE in teacher education and professional development that helps teachers and their students make sense of, shape, influence, and enact more MPE and physical activity learning experiences.
Racialized and Gendered Constructions of the “Ideal Server”: Contesting Historical Occupational Discourses of Restaurant Service
Authors: Dempsey Sarah E.
Published: October 2021

This essay takes a discourse-centered approach to understanding the historically contingent construction of restaurant service as a devalued occupational identity, showing how service is actively constructed as low wage and organized along hierarchies of gender, race, and class. These discursive constructions shape the relative visibility and legibility of workers as fully deserving of rights, compensation, and dignity. Building on prior research on the struggle over meanings of work, occupational identity, and gendered and racialized job segregation, the essay begins by tracing constructions of the “ideal server” predating the contemporary rise of restaurants from relations of servitude within and beyond the plantation economy, to the eventual entrenchment of tipping, and the gendered and feminized constructions of domestic service. It discusses racialized and gendered relations of servitude in the Pullman Company's dining cars and the eventual white feminization of waitressing. Adopting a historical narrative built on secondary literatures, it demonstrates the centrality of race, gender, and class to early occupational formations of service. It highlights how employers have cultivated occupational hierarchies and divisions as well as efforts by restaurant workers to transform how their labor is valued and compensated.
Management of Primary Squamous Cell Carcinoma of the Pancreas: A Case Report
Authors: Guo Danling , Chen Chao , Lv Sangying , Wu Guanzuan , Shi Wei , Li Huaifeng , Hu Hongjie
Published: October 2021

Introduction: Primary squamous cell carcinoma of the pancreas (SCCP) is a rare malignant tumor that has been reported in individual case reports only. The clinical data on primary SCCP treatment are limited. Therefore, the appropriate management strategy for this disease should be standardized.

Case Presentation: We present the case of a 63-year-old man admitted to our hospital for upper left abdominal pain for 2 months without weight loss or jaundice. Enhanced computed tomography (CT) and magnetic resonance imaging (MRI) of the abdomen revealed a mixed solid and cystic lesion in the pancreatic tail, measuring 35 × 37 mm in maximum diameter with enhancement. The patient was diagnosed with primary SCCP without metastasis, based on radiological and pathological findings. He did not receive neoadjuvant therapy postoperatively and was followed up by CT and MRI for 18 months without recurrence or metastasis.

Result: Complete resection is the most effective treatment for early stage primary SCCP. Abdominal MRI is an effective imaging tool for preoperative evaluation and postoperative follow-up of primary SCCP. The need for neoadjuvant therapy depends on various factors.

Conclusion: Primary SCCP is a tumor with poor prognosis. Risk factor control, early accurate radiologic evaluation, and individualized treatment strategies improve the quality of life and prolong the overall survival period of patients.
Epidemiological, Morphological, and Morphometric Study on Haemonchus spp. Recovered From Goats in Egypt
Authors: Gareh Ahmed , Elhawary Nagwa M. , Tahoun Amin , Ramez Amany M. , EL-shewehy Dina M. M. , Elbaz Elzahara , Khalifa Marwa I. , Alsharif Khalaf F. , Khalifa Refaat M. A. , Dyab Ahmed K. , Monib Mohmed Elsalahy M. , Arafa Mohsen I. , Elmahallawy Ehab Kotb
Published: October 2021

Goats can be infected by multiple groups of external and internal parasites.Haemonchusspp. are among abomasal parasites that can result in higher mortality and several considerable economic losses in goats. Early detection of parasites and better understanding of the major risk factors associated with infection are among the main strategies for controlling the infection. Considering this, information on hemonchosis in goats from Egypt, and the contribution of goats in the maintenance of the epidemiological foci of the disease is limited. This study investigated the prevalence ofHaemonchusspecies among 240 abomasum samples collected during postmortem examination of goat carcasses from Assiut Governorate, Egypt. Moreover, the association of the major risk factors to describe the epidemiological pattern of the disease was explored. This study demonstrated that 16.66% of abomasa samples harboredHaemonchusspecies. Additionally, age, sex, and sampling season were the most significant risk factors associated with infection. Following the variable factors under study, goats aged 1 year or older were at higher risk, with an infection rate of 22.14% (31 of 140), than those younger than 1 year (9%) [p= 0.008; odds ratio (OR) = 2.87; 95% confidence interval (CI), 1.30–6.35]. The infection rate was 25% (19 of 76) in males and 12.8% (21 of 164) in females [p= 0.024; odds ratio (OR) = 2.26; 95% confidence interval (CI), 1.13–4.53]. Moreover, the exposure to infection was higher in summer (22.22%) than in winter (8.33%) (p= 0.007; odds ratio (OR) = 0.318; 95% confidence interval (CI), 0.139–0.725). More importantly, three species of the parasite—Haemonchus contortus, Haemonchus placei, andHaemonchus longistipes—were identified for the first time, and the confirmation of the identification and morphological characterization of the worms was performed using light microscopy and SEM. Collectively, this study reveals interesting epidemiological, morphological, and morphometric findings associated with the occurrence of hemonchosis among goats in Egypt. This study suggests further research for exploring the major circulating species of the parasite in Egypt, which is mandatory for controlling the disease.
Syntaxin-1 and Insulinoma-Associated Protein 1 Expression in Breast Neoplasms with Neuroendocrine Features
Authors: Turkevi-Nagy Sándor , Báthori Ágnes , Böcz János , Krenács László , Cserni Gábor , Kővári Bence
Published: October 2021

Introduction: A subset of breast neoplasia is characterized by features of neuroendocrine differentiation. Positivity for Neuroendocrine markers by immunohistochemistry is required for the diagnosis. Sensitivity and specificity of currently used markers are limited; based on the definitions of WHO Classification of Tumours, 5th edition, about 50% of breast tumors with features of neuroendocrine differentiation express chromogranin-A and 16% express synaptophysin. We assessed the applicability of two novel markers, syntaxin-1 and insulinoma-associated protein 1 (INSM1) in breast carcinomas.

Methods: Hypercellular (Type B) mucinous carcinomas, solid papillary carcinomas, invasive carcinomas of no special type with neuroendocrine features and ductal carcinomas in situ of neuroendocrine subtype were included in our study. The immunohistochemical panel included chromogranin A, synaptophysin, CD56, syntaxin-1 and INSM1. The specificity of syntaxin-1 and INSM1 was determined using samples negative for chromogranin A, synaptophysin and CD56.

Results: The sensitivity of syntaxin-1 was 84.7% (50/59), with diffuse positivity in more than 60% of the cases. Syntaxin-1 also had an excellent specificity (98.1%). Depending on the definition for positivity, the sensitivity of INSM1 was 89.8% (53/59) or 86.4% (51/59), its specificity being 57.4% or 88.9%. The sensitivities of chromogranin A, synaptophysin and CD56 were 98.3, 74.6 and 22.4%, respectively.

Discussion: Syntaxin-1 and INSM1 are sensitive and specific markers of breast tumors with neuroendocrine features, outperforming chromogranin A and CD56. We recommend syntaxin-1 and INSM1 to be included in the routine neuroendocrine immunohistochemical panel.
A Non-Dominated Genetic Algorithm Based on Decoding Rule of Heat Treatment Equipment Volume and Job Delivery Date
Authors: Liang Yan , Zhang Qingdong
Published: October 2021

This paper investigated the flexible job-shop scheduling problem with the heat treatment process. To solve this problem, we built an unified mathematical model of the heat treatment process and machining process. Up to now, this problem has not been investigated much. Based on the features of this problem, we are intended to minimize Cmax, maximize the space utilization rate of heat treatment equipment, and minimize the total delay penalty to optimize the scheduling. By taking the dynamic process arrival under consideration, this paper proposed a set of decoding rules based on the heat treatment equipment volume and job delivery date to achieve a hybrid dynamic scheduling solution during one scheduling procedure. When the utilization rate of heat treatment equipment volume is maximized, and the job delivery date is taken under consideration, it is preferred to minimize the number of workpiece batches in the same job, and reduce the waiting time of the pending job. In combination with the improved adaptive non-dominated genetic algorithm, we worked out the solution. Furthermore, we verified the effectiveness of the proposed decoding rules and improved algorithm through algorithm comparison and calculation results. Finally, a software system for algorithm verification and algorithm comparison was developed to verify the validity of our proposed algorithm.
Correction: Schwarzkopf et al. Weaning Holstein Calves at 17 Weeks of Age Enables Smooth Transition from Liquid to Solid Feed. Animals 2019, 9, 1132
Authors: Schwarzkopf Sarah , Kinoshita Asako , Kluess Jeannette , Kersten Susanne , Meyer Ulrich , Huber Korinna , Dänicke Sven , Frahm Jana
Published: October 2021

The authors wish to make the following correction to their paper [...]
A Systematic Review of the Use of Technology to Monitor Welfare in Zoo Animals: Is There Space for Improvement?
Authors: Diana Alessia , Salas Marina , Pereboom Zjef , Mendl Michael , Norton Tomas
Published: October 2021

A top priority of modern zoos is to ensure good animal welfare (AW), thus, efforts towards improving AW monitoring are increasing. Welfare assessments are performed through more traditional approaches by employing direct observations and time-consuming data collection that require trained specialists. These limitations may be overcome through automated monitoring using wearable or remotely placed sensors. However, in this fast-developing field, the level of automated AW monitoring used in zoos is unclear. Hence, the aim of this systematic literature review was to investigate research conducted on the use of technology for AW assessment in zoos with a focus on real-time automated monitoring systems. The search led to 19 publications with 18 of them published in the last six years. Studies focused on mammals (89.5%) with elephant as the most studied species followed by primates. The most used technologies were camera (52.6%) and wearable sensors (31.6%) mainly used to measure behaviour, while the use of algorithms was reported in two publications only. This research area is still young in zoos and mainly focused on large mammals. Despite an increase in publications employing automated AW monitoring in the last years, the potential for this to become an extra useful tool needs further research.
Risk Factors for Bovine Cysticercosis in North-West Italy: A Multi-Year Case-Control Study
Authors: Rubiola Selene , Moroni Barbara , Carisio Luca , Rossi Luca , Chiesa Francesco , Martano Giuseppe , Cavallo Elisa , Rambozzi Luisa
Published: October 2021

Taenia saginata is the causative agent of bovine cysticercosis, a zoonotic parasitic disease with a worldwide distribution. Bovine cysticercosis is considered to be an important food safety issue responsible for human taeniasis and a major economic concern since infected carcasses undergo condemnation, freezing and downgrading. The aim of the current investigation was to assess the presence of farm-level risk factors for bovine cysticercosis in an endemic area in North-West Italy. A questionnaire was designed to collect information relating to several farm structural features, as well as management practices, environmental characteristics and attitudes of farmers. The questionnaire was administered in two separate time intervals by direct interview to previously selected case and control farms. Overall, 32 case farms and 131 control farms were included between 2005 and 2011 and 50 case farms and 192 control farms were included between 2014 and 2020. The present survey showed a significant association between the detection of bovine cysticercosis cases at slaughter and farm proximity to picnic spots, closeness of wastewater treatment plant effluents, loose-housing systems and presence of employees along with the family members, highlighting the need for targeted awareness raising policies.
Preliminary Study on Water Bodies’ Effects on the Decomposition Rate of Goldenrod Litter
Authors: Simon Szabina , Simon-Gáspár Brigitta , Soós Gábor , Anda Angéla
Published: October 2021

Leaf-litter input constitutes a major load in natural waters; therefore, to achieve and maintain high water quality, it is important to thoroughly examine and understand the litter decomposition process. The widespread Solidago canadensis exerts a negative effect on the composition of the ecosystem, causes extinction of species, and modifies the function of the system. In Hungary, goldenrod constantly spreads to newer areas, which can also be observed around Lake Balaton and at the bank of the Hévíz canal. In our investigation, we examined the decomposition rate of the leaves and stems of the goldenrod with the commonly applied method of leaf litter bags. As water temperature, ranging from 24.0 °C to 13.7 °C, decreases in Hévíz canal away from Lake Hévíz (−0.32 °C/100 m), we chose three different sampling sites with different water temperatures along the canal to determine how water temperature influences the rate of decomposition. For both leaves and stems, the fastest decomposition rate was observed at the first site, closest to the lake. At further sites with lower water temperatures, leaf litter decomposition rates decreased. Results observed through Hévíz canal demonstrated that higher water temperature accelerated the goldenrod decomposition dynamics, while the drift also impacted its efficiency.
Impact of Radio Occultation Data on the Prediction of Typhoon Haishen (2020) with WRFDA Hybrid Assimilation
Authors: Chen Shu-Ya , Nguyen Thi-Chinh , Huang Ching-Yuang
Published: October 2021

FORMOSAT-7/COSMIC-2 (FS7/C2) satellite was successfully launched in June 2019. The satellite provides about 5000 radio occultation (RO) soundings daily over the tropical and partial subtropical regions. Such plentiful RO soundings with high accuracy and vertical resolution could be used to improve model initial analysis for typhoon prediction. In this study, assimilation experiments with and without the RO data were conducted with the WRFDA hybrid system for the prediction of Typhoon Haishen (2020). The experimental results show a remarkable improvement in typhoon track prediction with RO data assimilation, especially when using a nonlocal refractivity operator. Results in cycling DA and forecast are analyzed and verified for the RO data impact. Diagnostics of potential vorticity (PV) tendency budget helps explain the typhoon translation induced by different physical processes in the budget. The typhoon translation is essentially dominated by horizontal PV advection, but the track deviation can increase due to the vertical PV advection with opposite effects in the absence of RO data. Sensitivity experiments for different model initial times, physics schemes, and RO observation amounts show positive RO data impacts on typhoon prediction, mainly contributed from FS7. Complementary, an improved forecast of Typhoon Hagupit (2020) is also illustrated for the RO data impact.
Planetary Boundary Layer Heights from Cruises in Spring to Autumn Chukchi-Beaufort Sea Compared with ERA5
Authors: Gu Mingyi , Moore G. W. K. , Wood Kevin , Wang Zhaomin
Published: October 2021

The planetary boundary layer height (PBLH) is a diagnostic field related to the effective heat capacity of the lower atmosphere, both stable and convective, and it constrains motion in this layer as well as impacts surface warming. Here, we used radiosonde data from five icebreaker cruises to the Chukchi and Beaufort Seas during both spring and fall to derive PBLH using the bulk Ri method, which were then compared with results from ERA5 reanalysis. The ERA5 PBLH was similar to but slightly lower than the ship observations. Clear and consistent seasonal changes were found in both the observations and the reanalysis: PBLH decreased from mid-May to mid-June and subsequently increased after August. The comparison with ERA5 shows that, besides surface temperature, biases in PBLH are also a function of wind direction, suggesting that the availability of upwind observations is also important in representing processes active in the boundary layer over the Arctic Ocean.
Heat Stress Responses in Birds: A Review of the Neural Components
Authors: Bohler Mark W. , Chowdhury Vishwajit S. , Cline Mark A. , Gilbert Elizabeth R.
Published: October 2021

Heat stress is one of the major environmental conditions causing significant losses in the poultry industry and having negative impacts on the world’s food economy. Heat exposure causes several physiological impairments in birds, including oxidative stress, weight loss, immunosuppression, and dysregulated metabolism. Collectively, these lead not only to decreased production in the meat industry, but also decreases in the number of eggs laid by 20%, and overall loss due to mortality during housing and transit. Mitigation techniques have been discussed in depth, and include changes in air flow and dietary composition, improved building insulation, use of air cooling in livestock buildings (fogging systems, evaporation panels), and genetic alterations. Most commonly observed during heat exposure are reduced food intake and an increase in the stress response. However, very little has been explored regarding heat exposure, food intake and stress, and how the neural circuitry responsible for sensing temperatures mediate these responses. That thermoregulation, food intake, and the stress response are primarily mediated by the hypothalamus make it reasonable to assume that it is the central hub at which these systems interact and coordinately regulate downstream changes in metabolism. Thus, this review discusses the neural circuitry in birds associated with thermoregulation, food intake, and stress response at the level of the hypothalamus, with a focus on how these systems might interact in the presence of heat exposure.
Circadian Sleep-Activity Rhythm across Ages in Down Syndrome
Authors: Lovos Annalysa , Bottrill Kenneth , Sakhon Stella , Nyhuis Casandra , Egleson Elizabeth , Luongo Alison , Murphy Melanie , Thurman Angela John , Abbeduto Leonard , Lee Nancy Raitano , Hughes Katharine , Edgin Jamie
Published: October 2021

Across all ages, individuals with Down syndrome (DS) experience high rates of sleep problems as well as cognitive impairments. This study sought to investigate whether circadian rhythm disruption was also experienced by people with DS and whether this kind of sleep disorder may be correlated with cognitive performance. A cross-sectional study of 101 participants (58 with DS, 43 with typical development) included individuals in middle childhood (6–10 years old), adolescence (11–18 years old), and young adulthood (19–26 years old). Sleep and markers of circadian timing and robustness were calculated using actigraphy. Cognitive and behavioral data were gathered via a novel touchscreen battery (A-MAPTM, Arizona Memory Assessment for Preschoolers and Special Populations) and parent questionnaire. Results indicated that children and adolescents with DS slept the same amount as peers with typical development, but significant group differences were seen in phase timing. The circadian robustness markers, interdaily stability and intradaily variability of sleep-wake rhythms, were healthiest for children regardless of diagnostic group and worst for adults with DS. Amplitude of the 24-h activity profile was elevated for all individuals with DS. In analyses of the correlations between sleep quality, rhythms, and cognition in people with DS, interdaily stability was positively correlated with reaction time and negatively correlated with verbal and scene recall, a finding that indicates increased stability may paradoxically correlate with poorer cognitive outcomes. Further, we found no relations with sleep efficiency previously found in preschool and adult samples. Therefore, the current findings suggest that a thorough examination of sleep disorders in DS must take into account age as well as circadian robustness to better understand sleep-cognitive correlations in this group.
A Multidisciplinary Telerehabilitation Approach for Supporting Social Interaction in Autism Spectrum Disorder Families: An Italian Digital Platform in Response to COVID-19
Authors: Vallefuoco Ersilia , Purpura Giulia , Gison Giovanna , Bonifacio Andrea , Tagliabue Luca , Broggi Fiorenza , Scuccimarra Goffredo , Pepino Alessandro , Nacinovich Renata
Published: October 2021

Due to its complexity and high variability in symptomology, autism spectrum disorder (ASD) requires a coordinated and multidisciplinary intervention to better support the different programs over time and to promote social interactions in all contexts of life. Telemedicine can offer a valuable contribution in this regard, providing low-cost and portable applications. In this paper, we presented an Italian project, SUPER, which aimed to foster collaboration and information sharing between ASD families, health services, and schools. SUPER provided a digital platform with several tools that were useful both to enhance general and specific ASD knowledge and to promote personalized programs for children with ASD. We conducted a preliminary user test for the platform with 30 participants (18 therapists and 12 parents of children with ASD) using the system usability scale (SUS). The total mean SUS score (89.2) showed that SUPER is an excellent, usable system. Moreover, we extracted the usability and learnability mean components from the SUS scores, which were 96.1 and 61.7, respectively. Our preliminary results indicate that SUPER is a very user-friendly application and its innovative telemedicine approach could be ahelpful communication and collaboration tool among the different contexts of care for children with ASD.
Collaborative Interorganizational Relationships in a Project-Based Industry
Authors: Khouja Ahmed , Lehoux Nadia , Cimon Yan , Cloutier Caroline
Published: October 2021

The project-based construction industry finds itself in a paradoxical situation: while it weighs heavily in the world economy, it does have a history of low productivity. One important issue that plagues the industry is related to the challenges that stem from collaborative efforts (or lack thereof) between actors. The objective of this paper is to explore how actors of the construction industry organize their inter-firm relationships while examining the characteristics of such interactions and the elements affecting them (drivers, barriers, facilitators, outcomes). These interactions and elements were uncovered using a systematic literature review. A qualitative content analysis was carried out to categorize these elements and to generate dimensions describing the forms. The 139 articles retrieved depicted 12 relational forms established between construction companies (in descending order of citation): partnering, alliancing, project delivery methods, supply chain integration, joint ventures, integrated project delivery, joint risk management, collaborative design, contingent collaboration, quasi-fixed network, resource sharing, and collaborative planning. A multitude of drivers, barriers, facilitators, and outcomes were found. An analysis of the results led to the conceptualization of a multidimensional profile, which allows for a practical and flexible identification of the relationship form potential partners in the construction sector intend to establish. To provide guidelines for the implementation of this profile, a three-step framework was developed.
Tonsillar Cancer with High CD8+ T-Cell Infiltration Features Increased Levels of Dendritic Cells and Transcriptional Regulation Associated with an Inflamed Tumor Microenvironment
Authors: Jimenez David Gomez , Sobti Aastha , Askmyr David , Sakellariou Christina , Santos Sofia Carreira , Swoboda Sabine , Forslund Ola , Greiff Lennart , Lindstedt Malin
Published: October 2021

Human papillomavirus (HPV) is the main causal agent of tonsillar cancer (TC) and HPV+ TC has a favorable prognosis compared to HPV− disease. In this study, we examined aspects of the tumor microenvironment of TC, focusing on T-cells, dendritic cells (DC), and macrophages. Fresh biopsies of TC and the contralateral healthy tonsil (HT) were obtained from 20 patients, analyzed by multiparameter flow cytometry, and assessed against a detailed HPV-status. Additionally, RNA-sequencing data from 38 TC samples available in the public database, The Cancer Genome Atlas (TCGA), were explored, focusing on the same leukocyte populations. HPV+ TC featured increased levels of CD8+ T-cells and antigen-presenting cells (cf. HPV− TC and HT, respectively). In HPV+ TC, CD8+ T-cell frequencies correlated to DC levels independently of tumor stage, HPV 16 copy number, and E7 oncogene expression as well as frequencies of other leukocytes. Similarly, RNA sequencing data were explored by dividing the HPV+ TCs according to predefined CD8+ T-cell scores in silico. Higher levels of genes expressed by antigen-presenting cells and effector T-cells, such as immune checkpoints and cytokines, were detected in the CD8HIGH HPV+ TC samples (cf. CD8LOW HPV+ TC). In conclusion, CD8HIGH HPV+ TC displays a unique inflammatory profile associated with increased effector T-cell functions and the presence of antigen-presenting cells in the tumor microenvironment. Further studies are warranted to assess if this information can be used on an individual basis to aid in prognosis and treatment decisions.
Vascular Damage in the Aorta of Wild-Type Mice Exposed to Ionizing Radiation: Sparing and Enhancing Effects of Dose Protraction
Authors: Hamada Nobuyuki , Kawano Ki-ichiro , Nomura Takaharu , Furukawa Kyoji , Yusoff Farina Mohamad , Maruhashi Tatsuya , Maeda Makoto , Nakashima Ayumu , Higashi Yukihito
Published: October 2021

During medical (therapeutic or diagnostic) procedures or in other settings, the circulatory system receives ionizing radiation at various dose rates. Here, we analyzed prelesional changes in the circulatory system of wild-type mice at six months after starting acute, intermittent, or continuous irradiation with 5 Gy of photons. Independent of irradiation regimens, irradiation had little impact on left ventricular function, heart weight, and kidney weight. In the aorta, a single acute exposure delivered in 10 minutes led to structural disorganizations and detachment of the aortic endothelium, and intima-media thickening. These morphological changes were accompanied by increases in markers for profibrosis (TGF-β1), fibrosis (collagen fibers), proinflammation (TNF-α), and macrophages (F4/80 and CD68), with concurrent decreases in markers for cell adhesion (CD31 and VE-cadherin) and vascular functionality (eNOS) in the aortic endothelium. Compared with acute exposure, the magnitude of such aortic changes was overall greater when the same dose was delivered in 25 fractions spread over 6 weeks, smaller in 100 fractions over 5 months, and much smaller in chronic exposure over 5 months. These findings suggest that dose protraction alters vascular damage in the aorta, but in a way that is not a simple function of dose rate.
Nicotinic Acetylcholine Receptor Subunit α7 Mediates Cigarette Smoke-Induced PD-L1 Expression in Human Bronchial Epithelial Cells
Authors: Kwok Hoi-Hin , Gao Boning , Chan Koon-Ho , Ip Mary Sau-Man , Minna John Dorrance , Lam David Chi-Leung
Published: October 2021

Tobacco smoking is the top risk factor for lung cancer development. Nicotine in cigarettes can induce addiction, and its derivatives become potent carcinogens after metabolic activation and activate oncogenic signaling in lung epithelial cells through their expressed nicotinic acetylcholine receptors (nAChRs). However, the effects of smoking on the tumor immune microenvironment are under investigation. In the current study, we investigated whether nicotine activation of nicotinic acetylcholine receptor subunit α7 (nAChRα7, CHRNA7) would induce PD-L1 expression in lung epithelial cells. The expression levels of nAChRα7 and PD-L1 in eight human bronchial epithelial cell (HBEC) lines were measured after treatment with cigarette smoke extract (CSE) or nicotine derivatives. The results showed that PD-L1 expression levels increased in HBECs after exposure to CSE or nicotine derivatives. This induction of PD-L1 expression could be diminished by treatment with CHRNA7 small-interfering RNA, and the relevant signaling was mediated via STAT3 phosphorylation and NRF2 expression. In summary, this study demonstrated that the well-known nicotine derivative-activated nAChRα7 could induce STAT3/NRF2 pathways and subsequently promote PD-L1 expression in normal lung epithelial cells. This information provides mechanistic insight into cigarette smoke-induced immune evasion in lung epithelial cells.
Prognostic Factor Utility of BAP1 Immunohistochemistry in Uveal Melanoma: A Single Center Study in Spain
Authors: Tabuenca Del Barrio Laura , Nova-Camacho Luiz Miguel , Zubicoa Enériz Alicia , Martínez de Espronceda Ezquerro Iñigo , Córdoba Iturriagagoitia Alicia , Borque Rodríguez-Maimón Enrique , García-Layana Alfredo
Published: October 2021

Even today, the mortality rate for uveal melanoma (UM) remains very high. In our research, we sought to determine which pathological and clinical features were correlated with the prognosis of UM. BAP1 (BRCA1-Associated Protein 1) gene mutation has been analyzed as one of the strongest predictors for metastasis in UM. The BAP1 gene codifies the BAP1 protein which has a tumor suppressor function. The presence of this protein can be determined by BAP1 immunohistochemical staining. Eighty-four uveal melanoma patients and forty enucleated eyeballs were examined. Metastasis was present in 24 patients. Nuclear BAP1 staining was low in 23 patients. The presence of a higher large basal diameter tumor (p < 0.001), tumor infiltrating lymphocytes (p = 0.020), and a lack of nuclear BAP1 immunostaining (p = 0.001) ocurred significantly more often in the metastatic group. Metastasis-free survival was lower in patients with low nuclear BAP1 staining (p = 0.003). In conclusion, to the best of our knowledge, this is the first time that BAP1 staining has been studied in uveal melanoma in a Spanish community. We believe that this technique should become routine in the pathological examination of uveal melanoma in order to allow adequate classification of patients and to establish an individual follow-up plan.
Zebrafish Model for Studying Dexamethasone-Induced Muscle Atrophy and Preventive Effect of Maca (Lepidium meyenii)
Authors: Ryu Bomi , Je Jun-Geon , Jeon You-Jin , Yang Hye-Won
Published: October 2021

Loss of myofibers during muscle atrophy affects functional capacity and quality of life. Dexamethasone, an inducer of rapid atrophy of skeletal myofibers, has been studied as a glucocorticoid receptor in muscle atrophy or motor neurodegeneration. In this study, we examined dexamethasone-induced muscle atrophy using zebrafish (Danio rerio), a vertebrate model, and assessed whether administration of Lepidium meyenii (maca) as a dietary supplement can prevent muscle atrophy. Changes in skeletal myofibers in zebrafish were evaluated after exposure to dexamethasone for different periods and at different concentrations. Under optimized conditions, zebrafish pre-fed with maca for 3 days were exposed to 0.01% dexamethasone for 1 h/day for 7 days. Thereafter, myofiber loss, damaged muscle contractile proteins, and abnormal exploratory behavior due to the structural and functional impairment of skeletal muscle associated with muscle atrophy were investigated using hematoxylin–eosin, immunofluorescence staining, and behavioral analyses. Our findings suggest that dexamethasone induces muscle atrophy in zebrafish, inhibiting exploratory behavior by inducing myofiber loss, inhibiting muscle contraction, and causing changes in endurance and velocity. Thus, the zebrafish model can be used to screen pharmaceutical agents and to study muscle atrophy. Furthermore, maca is a potential dietary supplement to prevent muscle atrophy, as it protects muscle fibers.
Increasing the Adherence of Metallic Copper to the Surface of Titanium Hydride
Authors: Pavlenko Vyacheslav Ivanovich , Gorodov Andrey Ivanovich , Yastrebinsky Roman Nikolayevich , Cherkashina Natalia Igorevna , Karnauhov Alexander Alexandrovich
Published: October 2021

Studies have been carried out to increase the adhesive interaction between a titanium hydride substrate and a copper coating. An additional layer containing chemically active groups was created on the surface of the spherical titanium hydride by chemisorption modification. This paper discusses the results of scanning electron microscopy (SEM) using energy-dispersive X-ray spectroscopic mapping of coatings obtained on spherical granules of titanium hydride before and after adsorption modification. The mechanism of interaction of the surface of spherical granules of titanium hydride and titanium sulfate salt is proposed. It is shown that the creation of a chemisorbed layer of hydroxotitanyl and the subsequent electrodeposition of metallic copper contribute to the formation of a multilayer shell of a titanium–copper coating on the surface of spherical titanium hydride granules (≡Ti-O-Cu-) with a high adhesive interaction. Results have been given for an experimental study of the thermal stability of the initial spherical granules of titanium hydride and granules coated with a multilayer titanium-copper shell.
Effectiveness of Custom-Made Foot Orthoses vs. Heel-Lifts in Children with Calcaneal Apophysitis (Sever’s Disease): A CONSORT-Compliant Randomized Trial
Authors: Alfaro-Santafé Javier , Gómez-Bernal Antonio , Lanuza-Cerzócimo Carla , Alfaro-Santafé José-Víctor , Pérez-Morcillo Aitor , Almenar-Arasanz Alejandro-Jesús
Published: October 2021

The aim of the present research was to determine the effectiveness of relieving calcaneal apophysitis pain using “off-the-shelf” heel-lifts and custom-made orthotics. Two intervention modalities were evaluated and compared in a 12-week follow-up trial. Inclusion criteria included 9- to 12-year-old children diagnosed with calcaneal apophysitis. Children were randomly stratified into treatment A (custom-made polypropylene foot orthoses) and treatment B (“off-the-shelf” heel-lifts) groups. Treatment effectiveness was measured by algometry and the visual analogical scale (VAS). A total of 208 patients were included. The treatment A group showed an increase in threshold algometry of 53.4% (95% CI 47.1% to 59.7%) and a decrease in VAS of −68.6% (95% CI −74.5% to −62.7%) compared with the treatment B group (p < 0.001). Calcaneal apophysitis pain perception was improved in both groups, but children who used custom-made foot orthoses showed a greater improvement.
Vegetation Characteristics and Recent Successional Trends of Sand Dune Habitats at the Bulgarian Black Sea Coast
Authors: Valcheva Magdalena , Sopotlieva Desislava , Apostolova Iva , Tsvetkova Nadya
Published: October 2021

Coastal dunes are valuable and vulnerable habitats that require scientific exploration and understanding of their natural processes; therefore, the aims of this study were to determine the current vegetation characteristics of dune habitats along the Bulgarian Coast in terms of species richness and cover of typical psammophytes and different non-psammophytic plant groups, and to analyze how they respond to certain environmental drivers. Data were collected from 12 dune systems. The research was focused on embryonic, white and grey dunes. The field work was conducted throughout July and August 2017. The vegetation was sampled at 154 phytosociological plots (5 m × 5 m). To understand how the vegetation responds to different drivers, we tested the correlation of defined species group richness and cover in relation to (1) the soil pH and EC values, (2) the distance from inland to the sea and (3) the range of different categories of land cover in the surrounding area. In order to track temporal vegetation changes, we compared the cover of defined species groups between 2003 and 2017. We registered a total number of 269 vascular plants, 12 bryophytes and 5 lichens. The strongest presence in all dune types, both in species richness and cover, was the group of grass- and shrubland plants. Weeds and ruderal plants had significant coverage in grey dunes, while the richness and cover of forest and alien plants were negligible among the studied dune habitats. The comparison of data between 2003 and 2017 revealed a substantial decline in the cover of psammophytes. We observed a clear pattern regarding the share of species richness of psammophytes and non-psammophytes among different locations. We detected that grey dunes were the most affected by the penetration of non-psammophytes.
Avocado Cover Expansion in the Monarch Butterfly Biosphere Reserve, Central Mexico
Authors: Sáenz-Ceja Jesús Eduardo , Pérez-Salicrup Diego Rafael
Published: October 2021

Avocado cultivation has reduced the extent of forest ecosystems in central Mexico, even in natural protected areas such as the Monarch Butterfly Biosphere Reserve (MBBR) where information on the extent and expansion dynamics of avocado cover is scant. This study aimed to identify avocado plantations within the MBBR through photo interpretation for the 2006–2018 period. Change rates of the avocado cover extent were calculated for the northern, central, and southern zones of the MBBR, and topographic attributes such as elevation, soil type, slope, and slope aspect were identified. A total extent of 958 ha is covered by avocado plantations within the MBBR. The southern zone hosted the largest area under avocado cultivation (570 ha), but the northern zone had the highest change rate between 2006 and 2018 (422%). Most avocado orchards have been established mainly in Acrisol soils, south-facing slopes, on steep hillsides, and in elevations between 2050 and 2800 m. The conversion from traditional agricultural lands has been the main mechanism for the establishment of avocado orchards. However, 40 ha under avocado cultivation derived from deforestation, mainly in the central zone. The expansion of avocado plantations could trigger environmental impacts, even threatening the overwintering habitat and the migratory phenomenon of the monarch butterflies.
Two New Species of Parastenocaris (Copepoda, Harpacticoida) from a Hyporheic Zone and Overview of the Present Knowledge on Stygobiotic Copepoda in Vietnam
Authors: Tran Ngoc-Son , Trinh-Dang Mau , Brancelj Anton
Published: October 2021

The number of freshwater species belonging to the genus Parastenocaris reported from ten countries of Southeast Asia is quite limited. Only two species have been reported so far from freshwater habitats there, compared to over 290 described species of the family Parastenocarididae worldwide. During the first study of the hyporheic zone of two small rivers in central Vietnam, two new species of the family Parastenocarididae were collected, Parastenocaris sontraensis sp. nov. and Parastencaris vugiaensis sp. nov. Both were collected from the gravel bar along the rivers (Suoi Da and Vu Gia river) using the Karaman–Chappuis method. Both the new species belong to the brevipes group of the genus Parastenocaris Kessler, 1913 sensu Lang (1948), and Reid (1995). Parastenocaris sontraensis sp. nov. is similar to P. hinumaensis Kikuchi, 1970 and Parastenocaris jane Karanovic, 2006 in the brevipes-group. Parastenocaris sontraensis sp. nov. differs from both Parastenocaris species by (i) Exp P3 with three segments in the male, (ii) caudal rami with seven setae, and (iii) caudal rami about 2.4 times as long as wide. Parastencaris vugiaensis sp. nov. can be distinguished from its congeners by the unique combination of the following characters: (i) the elliptical shape of caudal rami, (ii) apical seta (V) with bulbous base, and (iii) anal operculum extends beyond the end of anal somite. Until now, 14 stygobiotic species of Copepoda have been recorded in Vietnam (including two new species in this paper), which is relatively few compared with nearby Thailand with 25 species. Short comments on other stygobiotic Copepoda from Vietnam are added.