bluuebunny/crossref_metadata_2025 huggingface dataset:
Methods for Estimating Water Flows from Storms and Melting Snow – Case Study
Authors: Vitan E. , Hotupan Anca , Cilibiu C. , Ștef V.
Published: May 2022

The paper presents a case study for the evaluation and comparison of three calculation methods in terms of taking the water flows resulting from storms and after melting snow for a metropolitan area, whose rainwater catchment system is the most often completely over run, with frequent flooding in the area. The study compares the results of three calculation methods by correlating the relationships and values used in the literature with the real situation determined on several calculation sections, on different water courses in the proposed area. Based on comparisons for the obtained results, the paper presents a series of conclusions that could be useful in urban systems projects.
Inheritance Tax Evasion in Germany
Authors: Linseis Philippe
Published: May 2022

It is estimated, that between 2015 and 2024 about 3 trillion € will be inherited in Germany. Due to far-reaching tax exemptions, the inheritance tax revenue per year is only about 7 billion €. Despite the fact, that the income or value-added tax burden is significantly higher, the inheritance tax is more unpopular than other taxes. The objective of the paper is to figure out, whether there is evidence of high tax evasion in the field of German inheritance tax, with a view to the low tax revenue and the high unpopularity of the tax. Therefore, data from the official inheritance tax statistic is compared with secondary data from studies, which estimate the yearly wealth transfer to the next generation by using survey data. The assumption is, that asset classes, which are easy to evade, should be recorded with a lower amount in the official tax statistic, than in the survey-based estimations. But the results do not show evidence of high tax evasion in the field of inheritance tax. As until now, only a small part of the inheritances is recorded in the official inheritance tax statistic, for the future it is recommended to the government, to record all inheritances in the official statistic. Because of far-reaching reporting obligations, the tax offices anyway have knowledge of most inheritances and the additional bureaucratic effort to record the additional data in the official tax statistic is small.
Supervision, One of the Main Aspects in Social Work in Georgia
Authors: Gagoshidze Tamar
Published: May 2022

This article aims to describe the origin and development of supervision in Georgia, especially in the sector of social workers whose services are focused on the needs of people in difficulty. We will also talk about how training programs and providers (supervisors) are organized today. The intervention of supervisors in social work is very recent in Georgia, but it is notable that it has already impacted in a positive way, which statistics are shown in the article. The information is important for practicing supervisors, those in training, as well as those considering training, and also for those who would simply like to know more about the subject. Currently, scientific and statistical publications on the supervision of social workers in Georgia are quite scarce. We are interested, from a comparative and international perspective, in how supervision is developing in Georgia and where it stands today. The following description presents, from an outside observation, the result of research, statistical data, and interviews carried out with social workers, as well as with the group of supervisors of The LEPL Agency for state Сare and assistance for the (statutory) victims of human trafficking of the Ministry of Internally Displaced Persons from the Occupied Territories, Labor, Health and Social Affairs of Georgia.
The Competency of Changing the Deed Legal Framing in Case of Case Declination By the Competent Body. Resumption and Repetition of the On-Site Investigation
Authors: Palcu Pavel , Moroșteș Anca Florina
Published: May 2022

The criminal cases solved lately by the Prosecutor’s office by the court and by the local prosecutor’s offices brought under discussion and caused various opinions on the competency of changing the legal framework of the deed by hitting or other violent acts to attempted murder provided the competency being declined by the prosecutor’s offices by the district courts to the prosecutor’s office by the county court. This issue has become particularly important in view of the recent finding by the Constitutional Court that the elimination from absolute nullities of non-compliance with the rules of substantive jurisdiction and according to the quality of the person of the criminal prosecution bodies is unconstitutional [1]. There are also different points of view regarding the resumption and repetition of the on-site investigation, the conditions in which they intervene, who continues to carry it out, but also the way in which their forensic fixation is fixed.
Society and Law During the SARS-CoV-2 Health Crisis – Legal Thinking Issues and Normative Syntheses
Authors: Roghină Răzvan Cosmin
Published: May 2022

In this paper, we aim to observe, from a bird’s eye view, the meaning for which law dictates behaviors molded on values naturally hierarchized. The right to life is the absolute value that maintains its central position in any axiological hierarchy. Of course, we refer to the typology of societies connected to democratic and liberal values (more or less accentuated). We propose an approach with philosophical accents while traveling through the sphere of international regulations that protect rights and freedoms. All these will be related to the SARS-CoV-2 pandemic context. We will pay attention to the Romanian political praxis and constitutional justice during the health crisis. Finally, we will explore some legal and social thinking landmarks about what it means to approach a health crisis when it comes to understand and value freedom within the human existence coordinated by law.
Theoretical and Practical Analysis on the Quality of Active Subject of the Corruption Offenses of the Bank Clerk in the Sense of His Assimilation to the Civil Servant
Authors: Moise Gheorghe
Published: May 2022

The quality of the active subject of the bribery offense that can be retained to the bank clerk is based on the logical-legal argument that the duties he performs are subject to the control of a public authority, which recognizes that at least in terms of the importance of this activity. type of official we place ourselves in an area of authority and public interest. If at the beginning the legislator placed the bank clerk among the private persons who in terms of activities were likely to acquire the status of active subject of the crime of bribery, then he returned and placed him among the category of employees assimilated to civil servants. This much stronger link between the activity of this official, the purpose of his duties and the subordination of his own activity to a public authority, was the new argument underlying the current criminal regulations, which recognizes the quality of active subject of the offense of bribing the bank clerk.
Adaptive stochastic management of the storage function for a large, open reservoir using learned fuzzy models
Authors: Kozel Tomas , Stary Milos
Published: May 2022

The design and evaluation of algorithms for adaptive stochastic control of the reservoir function of a water reservoir using an artificial intelligence method (learned fuzzy model) are described in this article. This procedure was tested on the Vranov reservoir (Czech Republic). Stochastic model results were compared with the results of deterministic management obtained using the method of classical optimisation (differential evolution). The models used for controlling of reservoir outflow used single quantile from flow duration curve values or combinations of quantile values from flow duration curve for determination of controlled outflow. Both methods were also tested on forecast data from real series (100% forecast). Finally, the results of the dispatcher graph, adaptive deterministic control and adaptive stochastic control were compared. Achieved results of adaptive stochastic management were better than results provided by dispatcher graph and provide inspiration for continuing research in the field.
Analytical and numerical investigation of mechanical energy balance and energy loss of three-dimensional steady turbulent flows in open-channels
Authors: Mahmoudi Mahsa , Banihashemi Mohammad Ali
Published: May 2022

Study about the mechanical energy balance and the energy loss of 3-D turbulent flows in open-channels has its own complexities. The governing equation of the mechanical energy in turbulent flows has been previously known and includes turbulence parameters that their calculations or measurements are not easy. In this study, a form of the total mechanical energy equation that leads to a number of significant physical insights is analytically investigated, from which analytical relationships for the energy loss estimation in 3-D turbulent flows are defined. The effect of different turbulence parameters is reflected on the new relationships and analyzed by equalizations replacing unknown correlations with closure approximations using the numerical turbulence simulation. In order to investigate the application of the analytical relationships, numerical simulations are performed by using OpenFOAM software to solve the Navier-Stokes equations with the RSM turbulence model in open-channels with different geometries. Then, the contribution of the turbulence parameters to the total mechanical energy balance is evaluated in uniform and nonuniform turbulent flows and their difference is analyzed, that leads to identify the parameters affecting the friction and local losses. The results demonstrate that the magnitudes of the turbulent diffusion, the work done by the viscous stresses pertaining to the mean motion and the viscous diffusion of the turbulence energy are substantially smaller than the other terms of the total energy equation for turbulent flows in open-channels with different geometries, while the effect of the variations of the turbulence kinetic energy and the work done by the turbulence stresses, that has not been considered in the previous mechanical energy equations, is more important in complex flows. From a practical viewpoint, in order to study the details of the total mechanical energy balance and the energy loss in 3-D turbulent flows with the presence of the secondary currents, the proposed method can be useful.
Business Plan Concept for the Production of Rubber-Based Noise Reduction Walls in Slovakia for the Potential of Worn Tires Material Recovery
Authors: Potkány Marek , Krajčírová Lucia , Osvaldová Mária
Published: May 2022

The automotive industry is one of the fastest growing sectors and therefore places demand on many other sectors and increases the need for cooperation. With the development of the automotive industry, tires have become an integral part of society and the everyday life of the individual. As a result of the company’s development as a connection of transport, the demand for tires is increasing and the production of waste tires is also related to this. The use of end-of-life tires is almost endless and that is why tires are good to use in the circular economy. The circular economy is an economic system that aims to keep products and materials in use for longer, thus increasing their productivity and reducing waste. The paper presents a methodical concept of the plan for the extension of production capacities of rubber-based pressed products with the intention to produce noise reduction panels. The investment consists of the acquisition of the pressing machine and respective mould in the amount of € 180,000. Based on the selected assessment methods it can be stated that the NPV reaches + 69,360 €, Profitability index is 1.38, Internal Rate of Return is 23.8% and the payback period is estimated for 4 years and 4 months, at the considered production capacity of 14,000 m2/year.
Self-Knowledge, Who God Is, and a Cure for our Deepest Shame: A Few Reflections on Till We Have Faces
Authors: Baggett David , Baggett Marybeth
Published: May 2022

Till We Have Faces is a retelling of the Cupid/Psyche myth with a few twists, namely, a nonstandard narrator and the inability of Psyche’s sister, Orual, to see the palace. Both innovations lead the reader to understand better the dynamics at play in Orual’s effort to disrupt Psyche’s life with her husband/god. The inability to see, on Orual’s part, at first suggests that the nature of the story is primarily epistemological. What is it that can be reasonably known or inferred? Digging deeper, however, reveals that the epistemic elements are actually penultimate, and that instead the book bolsters an ethically robust epistemology. Who we are deeply affects what we can see. Before Orual could apprehend the nature of the gods, she had to be brutally honest about who she herself was. A victim of abuse who was constantly shamed for reasons beyond her control, she is a sympathetic character in several ways, but she gradually moves from being victim to victimizer, treating others as means to ends, and, in the case of Psyche, ‘loving’ her in a way that was more hate than love. Self-knowledge was needed for Orual to apprehend the truth. She comes to realize her treatment of Bardia, Batta, Redival, and especially Psyche was not as pure and altruistic as she had thought. She had to come to terms with the ugliness within herself, and her penchant for consuming others, before she could hope to see the beauty and love of the gods for what they were.
Insights of C. S. Lewis Concerning Faith, Doubt, Pride, Corrupted Love, and Dying to Oneself in Till We Have Faces
Authors: Breitenbach Zachary
Published: May 2022

In Till We Have Faces (TWHF), C. S. Lewis combines his passion for pagan mythology with his knack for communicating Christian truths via story, powerfully illustrating a number of theological and moral positions that are prominent in many of his other writings. This article examines two major themes in TWHF that are also emphasized heavily within Lewis’s prose: (1) maintaining faith (which is examined from various angles) in the face of various emotionally-driven temptations to doubt; and (2) recognizing that pride prevents us from knowing God and corrupts the love we have for others into a jealous hatred. The article uncovers a variety of ways that Lewis masterfully paints a picture via the characters and the story of TWHF that exemplifies religious and ethical insights within these two themes.
Reflecting Christ in Life and Art: The Divine Dance of Self-Giving in C. S. Lewis’s Till We Have Faces
Authors: Rials Megan Joy , Walls Jerry L.
Published: May 2022

This essay examines how C. S. Lewis, in Till We Have Faces, illustrates the Christian’s journey of sanctification through the pre-Christian story of his main character, Orual. She must gain two ‘faces’ in this process that correspond to the two books she writes. First, she must gain the face of self-knowledge through humility. The key components to this face are her memory and the act of writing of her first book, which together create a mirror to reflect her sin back to her. Second, Orual must gain the face of transformation through divine agape love. The humility she learned from her first face now allows her to enter what Lewis describes as the dance of self-giving, which is a crucial element to the second face of transformation in its mortification of Orual’s sin and selfishness. In the second face, Orual gains access to an ‘actual language’ that transcends merely verbal words and involves worshipping the god with her whole being, as do we in being transformed to reflect Christ more clearly. Orual’s writing is a form of this ‘actual language’, and her second book that shares her personal encounter with the god of the mountain reflects to others the beauty of the divine. Similarly, Christians should reflect Jesus with their lives and their art, which are inextricably intertwined because a life lived for Him is the highest form of artwork they can create.
Virtuality and Truth. On Literature in Merleau-Ponty’s Indirect Ontology
Authors: Pazienti Paola
Published: May 2022

This paper aims to investigate the importance of literature in Maurice Merleau-Ponty’s reflections concerning two strictly connected phenomenological themes: 1) the virtuality of objects and of existence itself; 2) the genesis of truth and the intuition of essences. According to Merleau-Ponty, modern novelists have adopted a phenomenological method: instead of ‘explaining’ the world through words, they ‘show’ the lifeworld and its paradoxes indirectly. In his view, and against Jean-Paul Sartre’s position, analyzing literature means developing a theory integrating perception and the imagination. Moreover, at the beginning of the 1950’s, this perspective led Merleau-Ponty to a deep revision of the Sartrian concepts of spontaneity and engagement in literary practice in favour of a theory of expression as style. As a conclusion, the paper argues for the key-role of literature in Merleau-Ponty’s indirect ontology as a way of rediscovering unity and harmony behind the metamorphosis of reality.
Bibliometric Assessment of International Developments in Paper Sludge Research Using Scopus Database
Authors: Zaki Siti Nuramirah Rabbani Muhammad , Abu Falah , Bahari Shahril Anuar , Osman Syaiful , Ahmad Mansur , Zakaria Mohd Nazarudin
Published: May 2022

Energy viability and waste disposal have been the two significant global complication. The consumption of paper and, subsequently, recycling are increasingly growing, contributing to vast quantities of paper sludge. Therefore, in waste disposal and environmental remediation, coping with massive volumes of paper sludge has received tremendous attention worldwide. Our purpose was to assess leading study advancements globally of paper sludge based on articles published, authors intra/inter-collaborations and accumulations of keywords. Throughout entire 1967–2019 duration, 2096 publications in paper sludge topic were mined using Scopus database. The findings revealed that the number of publications was less than 30 between 1967 and 1995, less than 60 between 1996 and 2005, less than 90 between 2006 and 2010 and more than 90 between 2011 and the recent year. Consequently, the yearly publishing is forecast to keep to expand. In a total of 125 journals, a total of 217 Canadian scholars from 155 universities lead to 263 papers, comprising 10.8 % total publications, where 261 (99.2 %) of 263 total English-language publications dominate the other countries/territories, while 0.8 % in French language. Also, from each of the 15 top countries, among the most productive universities, Université Laval was ranked 251st in World University Rankings 2021. In review, the following present developments in paper sludge comprise of: (i) cement, cellulose, bioethanol/biogas and concrete; (ii) phytoremediation and vermicompost and (iii) modelling (e.g., response surface methodology).
The Quality of Medical Care and the Quality of Medical Services under the Legislation of the Russian Federation: General and Different
Authors: Rabets A. M.
Published: May 2022

The article is devoted to theoretical and practical problems of distinguishing the concepts of “medical services” and “quality of medical services”, which in turn is important for clarifying the relationship between the concepts of “quality of medical services” and “quality of medical care”, as well as for distinguishing contractual and tort liability of medical organizations for the quality of medical services. Based on a comparison of the legislation on the provision of services, on health protection, on consumer protection and taking into account its interpretation given by the highest judicial authorities, the author comes to the conclusion that the subordinate regulatory legal acts on the provision of medical services are not in full compliance with the legislation on consumer rights, recommends using the experience of health authorities and the system of compulsory medical insurance for the examination the quality of medical care during the consideration of criminal and civil cases by the courts, related to the violation of the requirements for the quality of medical care.
Using Negative Pressure Wound Therapy With Instillation and Dwell Time to Create a Path to Closure for Older Patients With Chronic Wounds: A Retrospective Case Series
Authors:   PRISMA Health-Upstate, Greenville, South Carolina, Klein Robert
Published: May 2022

BACKGROUND: Chronic podiatric wounds are common causes of morbidity and mortality in older patients. Negative pressure wound therapy with instillation and dwell time (NPWTi-d) has been recommended in wounds with high levels of exudate, contaminated wounds, and wounds in which healing progression has stalled. PURPOSE: This retrospective case series describes the use of NPWTi-d to prepare 4 chronic wounds for closure in older patients with multiple comorbidities. METHODS: Patients (N = 4) ranged in age from 65 to 95 years and had wounds present for at least 90 days. Previous treatments included conventional NPWT and debridement. NPWTi-d consisted of instillation of 10 to 20 mL normal saline, dwell time for 1 minute, followed by 3-hour cycles of -125 mm Hg. Antibiotics were administered as needed. Wounds included a 210-day Wagner grade 3 diabetic foot ulcer (3.2 × 1.8 × 0.3 cm3), a 90-day dehisced wound (9.5 × 2.6 × 0.4 cm3), a 300-day neuropathic ulcer (0.7 × 0.5 × 2.1 cm3), and a 150-day Wagner grade 2 diabetic foot ulcer (4.5 × 3.3 × 0.9 cm3). NPWTi-d was applied for 3 to 33 days, when care was transitioned to advanced wound dressings. RESULTS: All 4 wounds responded positively to therapy, exhibiting reduced slough, growing granulation tissue, and size reduction. Closure was achieved in all cases. CONCLUSION: In these 4 patients, NPWTi-d, used as part of a treatment regimen including debridement, antibiotics, and advanced wound dressings, was effective in creating an environment that promoted wound healing and prepared the wounds for eventual closure.
Applying a Silver-containing Dressing to the Incision Site and Its Effect on the Development of Surgical Site Infection After Ostomy Closure: A Prospective Randomized Clinical Pilot Study
Authors:   Ankara City Hospital, Ankara, Turkey, Akin Tezcan , Kendirci Murat , Akgun Ali Emre ,   Ankara City Hospital, Ankara, Turkey, Cetinkaya Erdinc ,   Ankara City Hospital, Ankara, Turkey, Er Sadettin ,   Ankara City Hospital, Ankara, Turkey, Akin Merve ,   Ankara City Hospital, Ankara, Turkey
Published: May 2022

BACKGROUND: Surgical site infections (SSIs) can occur after colorectal surgery. Ionic silver has been used to prevent the development of SSIs. New-generation dressings, defined as total occlusive ionic silver–containing dressings, have been shown to reduce bacterial colonization in SSIs. PURPOSE: To evalute the effect of a silver hydrofiber dressing on the development of SSIs at the abdominal incision after ostomy closure. METHODS: There was a total of 37 eligible patients who underwent temporary ostomy closure. Five patients required an associated intervention during ostomy closure and were excluded. One patient was lost to follow-up. Hence, 32 patients were included in the study. Silver-containing occlusive dressings and conventional dressings were used in patients who underwent ostomy closure. In the control group (n = 16), the wound area was covered with a standard sterile gauze dressing for 24 to 48 hours, and then wound cleansing was performed with 10% povidone iodine, followed by daily dressing replacement with sterile gauze for 5 days. The patients in the study group (n = 16) were treated with a silver-containing hydrofiber dressing, which was not changed for 5 days following application in the operating room. RESULTS: At the end of the 30-day follow-up period, no SSIs were observed in the study group. When the dressing methods applied to the patient groups with and without SSIs were compared, SSIs developed at a higher rate in the control group (n = 4; 26.7%) compared with the study group (n = 0); this result was statistically significant (P = .043). CONCLUSIONS: In this study, the use of a wound care product containing ionic silver reduced the rate of SSIs related to ostomy closure. Multicenter, randomized, clinical studies involving a larger number of patients are needed. In addition, occlusive wound dressings with and without silver should be investigated in further studies.
La poésie lyrique: inter-générique, transnationale, translinguistique?
Authors: Ramazani Jahan
Published: May 2022

Cet essai avance une série de postulats. 1) La poésie lyrique n’est pas définissable par des caractéristiques exclusives. 2) Elle peut être décrite par des stratégies formelles non-exclusives encodées dans les textes et les communautés. 3) Elle constitue un genre, ce dernier étant compris comme une fusion de la poétique et de l’herméneutique. 4) Elle vit historiquement mais survit de façon transhistorique. 5) Elle n’est ni simplement personnelle, ni entièrement impersonnelle. 6) Elle se distingue des genres plus empiriques et mimétiques par la densité de sa médiation verbale et formelle. 7) Elle est inter-générique. 8) Elle est transnationale. 9) Elle doit être étudiée à la fois au niveau macro et micro. 10) Elle met en évidence l’hybridation interculturelle, la créolisation et la vernacularisation. 11) Elle accomplit ceci «au sein de», et «entre» les langues. 12) Enfin, elle n’est pas morte et elle n’est pas exclusivement une forme appartenant à l’élite.

Mots-clés: CRÉOLISATION. HYBRIDATION. POÉTIQUE INTER-GÉNÉRIQUE. POÉTIQUE TRANSNATIONALE. VERNACULARISATION.
Pourquoi parler de lyrique médiéval?
Authors: Butterfield Ardis
Published: May 2022

Quelle pourrait être la contribution du lyrique médiéval à ce que l’on appelle les New Lyrics Studies? Cet article soutient que la culture manuscrite médiévale offre une nouvelle compréhension de la «lecture lyrique», qui renvoie au passage à l’imprimé des poèmes d’Emily Dickinson opéré au XIXe siècle (tel que le décrit Virginia Jackson), et remet en question les hypothèses influentes que cette lecture formule au sujet du lyrique. Le monde du poème court en moyen anglais qui est trilingue, donc non anglocentré, se réclame différemment de la littérarité, et implique la présence (largement non-écrite) de la musique. La pratique répandue de la citation sape encore davantage le concept d’un objet écrit particulier, rendu familier par l’imprimerie moderne. Des exemples tirés de divers manuscrits suggèrent des modes de lecture tant latéraux que verticaux, attentifs au réseau instable de traces verbales et au rôle fuyant de la mélodie. Ils sont aptes à être appliqués à la poésie postmédiévale.

Mots-clés: CHANSON. FORME. LECTURE DE SURFACE. LYRIQUE. MÉDIÉVAL.
«Écoutez!»: Revisiter la poésie lyrique de mariage, réinterpréter les caractéristiques lyriques, reconnaître les «flashlights» lyriques
Authors: Dubrow Heather
Published: May 2022

Bien que l’épithalame lyrique ait engendré un commentaire critique considérable, un élément n’a pas été identifié, ni discuté précédemment. Les «flashlights» peuvent être définies comme des impératives qui attirent l’attention sur une expérience sensorielle ou un évènement particuliers, souvent mais pas toujours perçus par la vue ou l’ouïe, ou plusieurs sens en même temps. Parmi les exemples courants se trouvent «Voir» (see and behold), «Écoutez!» (Hark); des mots comme «Observe» (Mark) peuvent être identifiés comme des variantes ou des proches parents. Analyser ces «flashlights» nous permet de tracer les caractéristiques clés du lyrique en général et de l’épithalame en particulier, notamment les interactions entre locuteur et public ainsi que la relation de ce genre à l’espace et à la narration.

Mots-clés: DESTINATAIRES. ÉPITHALAME. LYRIQUE. NARRATIVITÉ. SPATIALITÉ.
Isolation, characterization and UPLC-DAD based quantification of antiplasmodial isoquinoline alkaloids from Cissampelos pareira L.
Authors: Sharma Upendra , Kumari Surekha , - Anmol , - Shivani , Agrawal Prakhar , Sahal Dinkar
Published: May 2022

C. pareira L. is a centuries-old traditional medicinal plant utilized to treat various diseases like asthma, diarrhea, fever, heart disorders, snakebite, vomiting, malaria, pneumonia, dog bite, inflammation and abdominal pain. Globally, based on traditional knowledge, different parts of this plant are being used individually or in combination in various forms to manage malaria. However, the scientific investigation for validating the most effective part of this plant against malaria parasite has not been done. Therefore, current study aimed to evaluate in vitro antiplasmodial activity of extracts/fractions (whole plant) and decoctions from different parts (roots, stem, leaves and whole plant) of C. pareira against different strains of Plasmodium falciparum followed by antiplasmodial activity guided isolation and quantification of isoquinoline alkaloids in extracts/fractions and decoctions. All extracts/fractions/decoctions and molecules isolated from active fractions were investigated for antiplasmodial activity. Results showed that the chloroform fraction of whole plant was the most promising with IC50 (µg/mL) of 0.79 (Pf3D7) and 2.26 (PfINDO) followed by root decoction having IC50 (µg/mL) 10.22 (Pf3D7) and 7.7 (PfINDO). Among three isolated molecules, two bisbenzylisoquinoline alkaloids namely curine (2) [IC50 (µM) 1.46 (Pf3D7) and 0.51 (PfINDO)], and O,O-dimethylcurine (1) [IC50 (µM) 0.92 (Pf3D7) and 2.6 (PfINDO)], were found to be the most potent against P. falciparum strains. The antiplasmodial activity of chloroform fraction was further validated by the developed UPLC-DAD method, which showed the highest quantities of curine (2) (~107 mg/g) and O,O-dimethylcurine (1) (~15 mg/g) in this fraction. This study showed that the root decoction was more effective than decoctions of each of the other parts of the plant and whole plant hydroalcoholic extract. Further, for the first time, this study validates the traditional use of C. pareira whole plant to manage malaria, providing further opportunity to explore the tremendous structural and chemical diversity of isoquinoline alkaloids for antimalarial drug development.
Simultaneous Estimation of Gas Adsorption Equilibria and Kinetics of Individual Shaped Adsorbents
Authors: Azzan Hassan , Rajagopalan Ashwin Kumar , L'Hermitte Anouk , Pini Ronny , Petit Camille
Published: May 2022

Shaped adsorbents are typically employed in several gas separation and sensing applications. The performance of these adsorbents is dictated by two key factors, their adsorption equilibrium capacity and kinetics. Often, adsorption equilibrium and textural properties are reported for materials. Adsorption kinetics, despite its impact on performance in a given application, are seldom presented due to the challenges associated with measuring them. Therefore, robust and practical experimental approaches -- preferably using small quantities of material -- to characterize both the adsorption equilibrium and kinetics for shaped adsorbents is necessary. The overarching goal of this work is to develop an approach to characterize the adsorption properties of shaped adsorbents with less than 100 mg of sample. To this aim, we have developed an experimental dynamic sorption setup, complemented with mathematical models, to describe the mass transport in the system. We embed these models into a derivative-free optimizer to predict model parameters for adsorption equilibrium and kinetics. We evaluate the performance of our approach using three adsorbents. Further, we test the robustness of our mathematical framework using a digital twin. We show that framework can rapidly and quantitatively characterize adsorption properties at a milligram scale, making it suited for screening of novel porous materials.
Folding Coarse-Grained Oligomer Models with PyRosetta
Authors: Fobe Theodore L. , Walker Christopher C. , Meek Garrett A. , Shirts Michael R.
Published: May 2022

Non-biological foldamers are a promising class of macromolecules that share similarities to classical biopolymers such as proteins and nucleic acids. Currently, designing novel foldamers is a non-trivial process, often involving many iterations of trial synthesis and characterization until folded structures are observed. In this work, we aim to tackle these foldamer design challenges using computational modeling techniques. We developed CG PyRosetta, an extension to the popular protein folding python package, PyRosetta, which introduces coarse-grained (CG) residues into PyRosetta, enabling the folding of toy CG foldamer models. Through systematic variation of CG parameters in these models, we can investigate various folding hypotheses and generate folding principles at the CG scale to inform the design process of new foldamer chemistries. We demonstrate CG PyRosetta’s ability to identify minimum energy structures with a diverse structural search over a range of simple models and two hypothesis-driven parameter scans investigating the effects of side-chain size and internal backbone angle on secondary structure. We are able to identify several types of secondary structures from single- and double-helices to sheet-like and knot-like structures. We show how side-chain size and backbone bond angle both play an important role in the structure and energetics of these toy models. Optimal side-chain sizes promote favorable packing of side-chains, while specific backbone bond-angles influence the specific helix type found in folded structures.
Pulmonary toxicity induced by the use of bleomycin in patients with germ cell testicular tumors
Authors: Ognerubov Nikolai A. , Antipova Tatyana S. , Ognerubov Sergey A.
Published: May 2022

Introduction. Pulmonary toxicity induced by bleomycin is a dangerous complication of polychemotherapy in patients with germ cell tumors. It occurs with a frequency of up to 46%, and in 14% of cases it is fatal.
Aim. To present cases of pulmonary toxicity during polychemotherapy with the inclusion of bleomycin for testicular germ cell tumors.
Materials and Methods. Two patients aged 43 and 33 years old with testicular germ cell tumors were under observation after orchifuniculectomy who underwent chemotherapy according to the BER scheme (bleomycin + etoposide + cisplatin) in the steady-state mode in 4 and 6 cycles respectively. Positron emission tomography combined with computer tomography (PET/CT) with 18F-fluorodeoxyglucose was performed when clinical symptoms appeared at the end of treatment.
Results. Histologically, the tumor in a 33-year-old patient was a mixed tumor seminoma, embryonal cancer with teratoid cancer elements. Abdominal spiral computed tomography revealed metastases to retroperitoneal lymph nodes. In a 43-year-old patient, the tumor had the structure of fetal cancer with multiple metastases to the lungs, mediastinal lymph nodes and retroperitoneal lymph nodes. Six and four cycles of polychemotherapy according to the BER regimen were administered, respectively. The cumulative dose of bleomycin was 540 and 360 mg in 18 and 12 injections. Treatment was accompanied by the development of febrile neutropenia with G-CSF correction. These risk factors should be considered the most significant. The appearance of respiratory symptoms during treatment should be regarded as a manifestation of pulmonary toxicity. PET/CT is the method of choice for diagnosis. The clinical picture in the observed patients, as well as changes on PET/CT, were detected 2 weeks after chemotherapy was completed.
Conclusion. Pulmonary toxicity induced by the use of bleomycin in patients with germ cell testicular tumors is a very dangerous complication, sometimes with a lethal outcome. Therefore, its early diagnosis taking into account risk factors is of great importance in clinical practice. Among medical imaging methods, a special role is played by PET/CT, which allows predicting toxicity before the clinical and radiological debut.
The dawn of Japanese corporate governance in the Yamato era
Authors: Jerzemowska Magdalena , Jerzemowski Jacek
Published: May 2022

Background: The subject of the study is Japanese corporate governance during the formation of the centralised Yamato state and the development of its specific features. Little has been written about the structures and characteristics of governance in ancient Japan. Thus, the article may contribute to reducing the gap that exists in this field in the Polish literature.

Research purpose: The aim is to try to show Japanese corporate governance in Yamato (until 645) and to identify those unique features and their roots that have not lost their relevance to this day. The paper verifies the thesis that the model of corporate governance developed in the Yamato period is a product of uji traditions and customs, as well as the hybridisation of culture and rights of the Japanese clans and Chinese Empire.

Methods: The analysis is carried out at macro and microeconomic levels based on a review of the literature on the history of Japan and corporate governance. The most important political, social, and economic events in the early Yamato are presented in building the centralised state, its governance, control, and incentive structures. The uji, the be, and the uji-kabane system are shown as mechanisms of governance.

Conclusions: The analysis confirmed the thesis that the Yamato corporate governance model is the result of the hybridisation of cultures and the laws of Yamato and China and that it created the foundations of Japan’s unique contemporary model of corporate governance
Determining Pre-Service Teachers’ Astronomy-Related Self-Efficacy Belief Levels
Authors: Ezberci Cevik Ebru , Bektaş Oktay
Published: May 2022

This study aims to reveal the astronomy-related self-efficacy beliefs of pre-service teachers studying science education, primary school education, and social studies education programmes. The study is conducted using the survey design, a quantitative research method. The study sample consists of 322 pre-service teachers in their third or fourth year of a science education, primary school education, or social studies education programme at a university in Turkey’s Central Anatolia Region during the 2016 fall semester. The Astronomy Teaching Self-Efficacy Belief Scale developed by Güneş was used as the data collection tool. SPSS 22 was used to analyse the data, and the analyses benefited from descriptive and inferential statistics. Based on the findings, the pre-service teachers’ total scores for astronomy self-efficacy showed no significant difference in terms of certain variables (i.e., gender, age, year, and having taken a previous astronomy course). However, significant differences were found regarding self-efficacy scores in terms of the programme and having taken part in astronomy and sky-gazing activity. Concerning the obtained results, the following suggestions can be made: pre-service teachers should be actively involved during the astronomy course, and their classroom management experiences should be promoted to improve their astronomy self-efficacy belief levels.
Simultaneous determination of nitrite and nitrate in meat and meat products
using ion-exchange chromatography
Authors: Mazumdar R.M. , Sharif M. , Khan T.A. , Rahman M.M. , Abdullah A.T.M.
Published: May 2022

Nitrite and nitrate salts are widely used as curing agents to preserve meat and meat
products. Despite the benefits of using these salts in meat processing, it has some adverse
health effects. The high concentration of these salts produces nitric oxide through various
metabolic reactions followed by the generation of carcinogenic nitrosamines. In this study,
a chromatographic method was developed for the simultaneous determination of nitrite
and nitrate level in meat and meat products. Samples were collected from four different
locations in Dhaka, Bangladesh and analysed by ion-exchange chromatography. Most
relevant validation parameters were evaluated using the standard validation procedure.
The linearity was more than 0.995 and recoveries for nitrite and nitrate were more than
96% and 97%, respectively. The Limit of detection (LOD) for nitrite and nitrate was 0.10
and 0.26 mg/L, respectively. Results showed that the highest nitrite and nitrate content
was 66.04±0.55 and 55.02±1.4 mg/kg, respectively. However, nitrite and nitrate levels
were lower than the prescribed value by international guidelines. Besides, temperaturebased recovery revealed that 80°C was the optimum temperature for recovering the nitrite
and nitrate from meat and meat products. This developed method applying ion-exchange
chromatography can monitor the content of nitrite and nitrate in meat and meat products to
ensure food safety.
Research Progress in TCM Treatment of Retinitis Pigmentosa
Authors: Yang Qianqian , Zhang Li , Cheng Jinhan , Tong Jingan
Published: May 2022

Retinitis pigmentosa (RP) is a genetic eye disease characterized by primary dystrophic degenerative lesions of photoreceptor cells and retinal pigment epithelium. Although there are many treatment methods, there is still a lack of effective methods to restore visual acuity and visual field. Traditional Chinese medicine ophthalmologists have been conducting extensive clinical research on retinitis pigmentosa for a long time and have achieved significant progress. The paper is a summary of the progress of traditional Chinese medicine in the treatment of retinitis pigmentosa in the last five years.
Mercado ganadero y estratificación social en el medio rural catalán (siglo XIV)
Authors: Sales Favà Lluís
Published: May 2022

The article looks at the place of livestock rearing in the Catalonian peasant economy during the fourteenth century. The results are derived from the analysis of 126 notarial ledgers dating from 1328 to 1371 and pertaining to various towns in the Les Gavarres region of northeast Catalonia. A case study of the town of Cassà de la Selva highlights the role of a flexible and widely used animal-lease contract known as the comanda. The peasant serfs who inhabited the region chose which markets to attend in their search for the best offers and there was geographical specialization in the type of domestic animals that were kept. The article also highlights the participation of peasants and other local specialized trade agents, and the role of the mas – peasant farm – in the animal market. The author discovered that a small group of local actors from the most powerful farms, along with a group of families from the urban center, supplied the rest with animals. In some cases, these actors became full professionals and contributed to social polarization within the community. An example of this was the cattle dealer Bonanat Alagot, who monopolized the trade of draft animals in his area of influence during the fourteenth century.
CCUS-Aksi Mitigasi Gas Rumah Kaca dan Peningkatan Pengurasan Minyak CO2-EOR
Authors: Sugihardjo Sugihardjo
Published: May 2022

Emisi CO2 pada saat ini sangat tinggi yaitu pada tingkat lebih dari 400ppm di atmosfer, karena pembakaran bakar fosil yang terus menerus meningkat seiring dengan aktivitas industri yang terus bertambah. CO2 dalam jumlah besar yang dapat diterapkan dalam kegiatan CCS dan CCUS berasal dari industri atau pabrik. CCUS sangat potensial diterapkan di Indonesia, mengingat banyak lapangan tua dan sumber CO2 yang belum dimanfaatkan. Telah dilakukan studi CCUS atau CO2-EOR dengan kasus lapangan di Sumatera Selatan. Dengan analisis mulai screening lapangan, studi laboratorium, simulasi reservoar, integrasi sumuran, penangkapan dan transportasi CO2, serta monitoring. Kajian simulasi reservoar menunjukkan bahwa injeksi CO2 dapat menaikkan perolehan minyak serta juga dapat terjadi penyimpanan CO2 yang merupakan mitigasi gas rumah kaca.
Занимательная этика
Authors:   Институт философии РАН, Балашов Л.Е.
Published: May 2022

Настоящая книга — первый опыт такого рода на русском языке. Книга призвана показать этику и занимательное размышление на темы морали. В книге публикуются заметки и тексты, которые носят в основном дискуссионный, полемический характер, так сказать, с перчиком. Также их можно рассматривать как иллюстрации, как дополнительный поясняющий материал к учебному курсу по этике. Книга заставляет думать, причем без всякого насилия и принуждения. В конце учебного пособия даются задачи и упражнения по этике. В приложении приведены мысли-высказывания разных авторов на темы морали. «Занимательная этика» является продолжением двух изданных книг автора — «Занимательной философии» и «Этики». Для студентов и преподавателей высшей школы, для учащихся и учителей старших классов средних учебных заведений, для всех интересующихся проблемами морали.
Modelo de puntuación crediticia para tarjeta de crédito en México: una aproximación logística
Authors: Reyes Morales Marco Antonio , Sosa Miriam
Published: May 2022

El riesgo de crédito es una de las principales preocupaciones de los organismos de supervisión y regulación financiera, así como de las instituciones bancarias. Así, se propone un modelo de puntuación crediticia basado en una regresión logística, para analizar la probabilidad de incumplimiento por segmentos de una cartera de clientes de tarjeta de crédito de una institución mexicana. Los resultados muestran que el modelo propuesto tiene un alto nivel de predictibilidad y de estabilidad, tanto fuera como dentro del periodo de modelado, la comprobación de monotonicidad, también asegura que el modelo tenga un alto nivel de precisión. La originalidad subyace en que existen escasos estudios sobre modelos de puntuación crediticia para México, el resultado del modelo tiene alto nivel de precisión y arroja como resultado una tabla de puntuación de fácil interpretación para el personal bancario. Se concluye que el modelo es confiable y con alto nivel de ajuste.
El efecto del empoderamiento en empresas minoristas ante la pandemia a causa del COVID-19. El caso de Walmart
Authors: Rebolledo Iglesias Gilberto , De León de la Garza Elda Ayde , Aranda Contreras Elda Aurora
Published: May 2022

El presente estudio es una investigación exploratoria sobre el empoderamiento, cómo se aplica en Walmart de México y de Estados Unidos y el efecto que la pandemia del COVID 19 tuvo en estas tiendas. Se presenta un marco teórico con las ideas más importantes del empoderamiento, las tiendas minoristas y la pandemia. Para los resultados se hizo un estudio documental en el que se compararon las prácticas que realiza Walmart en México y en Estados Unidos. Se encontró que en ambos países se realizan prácticas muy parecidas en el tema del empoderamiento de empleados habiendo solo diferencia significativa en prácticas fuera del trabajo y en cuanto a la pandemia, las acciones realizadas son las dictadas por organismos de salud y que son replicables en muchos negocios.
Implementation of Analytic Network Process Algorithm in E-Lowker System
Authors: Wijaya Herry Derajad , Gunawan Wawan
Published: May 2022

Job vacancies information system at this time that there are still many companies that use the manual method to get the best employees and the number of job applicants who have not used the internet as a medium of information, but in this case the research aims to facilitate companies in getting the best employees, namely using the ANP Method in a web-based job information system and facilitate job applicants in utilizing internet media as a source of information that has been provided by the company. The ANP method is to find the weighted sum of the performance ratings for each alternative on all attributes, in this study the programming languages ​​used are PHP, MySQL database, CSS and Java Script. The criteria used in this study are education, experience, age and expertise. In this study shows that the Implementation of the ANP Method in the Web-Based Job Vacancy Information System is able to produce the best prospective workers for the company in accordance with the criteria