bluuebunny/crossref_metadata_2025 huggingface dataset:
Nano-Drug Delivery Systems Entrapping Natural Bioactive Compounds for Cancer: Recent Progress and Future Challenges
Authors: Chavda Vivek P. , Patel Aayushi B. , Mistry Kavya J. , Suthar Suresh F. , Wu Zhuo-Xun , Chen Zhe-Sheng , Hou Kaijian
Published: March 2022

Cancer is a prominent cause of mortality globally, and it becomes fatal and incurable if it is delayed in diagnosis. Chemotherapy is a type of treatment that is used to eliminate, diminish, or restrict tumor progression. Chemotherapeutic medicines are available in various formulations. Some tumors require just one type of chemotherapy medication, while others may require a combination of surgery and/or radiotherapy. Treatments might last from a few minutes to many hours to several days. Each medication has potential adverse effects associated with it. Researchers have recently become interested in the use of natural bioactive compounds in anticancer therapy. Some phytochemicals have effects on cellular processes and signaling pathways with potential antitumor properties. Beneficial anticancer effects of phytochemicals were observed in both in vivo and in vitro investigations. Encapsulating natural bioactive compounds in different drug delivery methods may improve their anticancer efficacy. Greater in vivo stability and bioavailability, as well as a reduction in undesirable effects and an enhancement in target-specific activity, will increase the effectiveness of bioactive compounds. This review work focuses on a novel drug delivery system that entraps natural bioactive substances. It also provides an idea of the bioavailability of phytochemicals, challenges and limitations of standard cancer therapy. It also encompasses recent patents on nanoparticle formulations containing a natural anti-cancer molecule.
Sharing Channel Strategy With Customers’ Collaborative Consumption Behaviors
Authors: Dong Shaozeng , Luan Mingqiao , Chen Lingming , Ali Zulqurnain
Published: March 2022

Associated with the sharing economy, collaborative consumption behaviors often take place among customers. Different from the traditional consumption that customers purchase the product and own it, in the sharing economy, customers can access the product only for a particular period and the ownership of the product also belongs to the firm. In this paper, we develop a theoretical analysis model, and investigate the intrinsic connection between collaborative consumption and the sharing channel strategy. Adopting the sharing channel strategy, the firm has a chance to expand the market demand and improve its profit. In addition, we examine the impacts of other influential factors on a firm’s decisions, such as the unit product cost, surplus-value, and service capability coefficient.
Harmful Stress-Related Couple Processes During the COVID-19 Pandemic and Lockdown: A Longitudinal Dyadic Perspective
Authors: Galdiolo Sarah , Culot Stéphanie , Delannoy Pauline , Mauroy Anthony , Laforgue Florine , Gaugue Justine
Published: March 2022

In March 2020, the World Health Organization declared the disease caused by SARS-CoV-2 coronavirus “pandemic.” To reduce the risk of contamination, many countries have ordered a lockdown characterized by social distancing and restrictive isolation measures. While the lockdown has proven to be quite effective in terms of physical health, little is known about its impact on couple satisfaction in a dyadic perspective. The current research was a 4-waves longitudinal study (i.e., from March to July 2020) with the objective to examine the trajectory of couple satisfaction during the lockdown with a dyadic perspective (N = 108 couples), including the presence (or absence) of children at home, the number of hours spent together, and the duration of the relationship as time-invariant predictors and the partner’s couple satisfaction trajectory as a time-varying covariate. Results showed positive intraindividual changes in couple satisfaction during the lockdown, especially an increase in partners’ effectiveness for resolving couple conflicts and a decrease in partners’ aggressiveness. Partners had also perceived the influence of the lockdown as more and more positive over time on couple and family functioning. Finally, the couple satisfaction of both partners changed in tandem during the lockdown: The perception of the couple relationship seems to similarly evolve between partners.
Drivers of Green Entrepreneurial Intention: Why Does Sustainability Awareness Matter Among University Students?
Authors: Prabowo Hartiwi , Ikhsan Ridho Bramulya , Yuniarty Yuniarty
Published: March 2022

Entrepreneurship is an essential aspect of economic growth because of its contribution to people’s welfare through employment opportunities. Universities offer compulsory entrepreneurship subjects for students with the support of government policies. Therefore, this study aimed to determine the factors that influence the students’ intentions to become green entrepreneurs using contextual aspects as moderators. The applied theoretical model was the planned behavior (TPB) that adds cultural values and cognitive knowledge. The sample included 305 students from 10 private universities in Jakarta. The results showed that green entrepreneurial intentions are affected by perceived behavioral control (PBC), cultural values, cognition knowledge, and contextual factors. However, they lack a significant effect on attitudes toward behavior and subjective norms. Second, the contextual factors can moderate the relationship between variables and significantly affect green entrepreneurial intentions. Third, they moderate attitudes toward behavior and cognitive knowledge with green entrepreneurial intentions. Contrastingly, other factors had no effect when contextual factors moderated the relationship.
Behavioral and Psychological Symptoms of Dementia as a Means of Communication: Considerations for Reducing Stigma and Promoting Person-Centered Care
Authors: Warren Alison
Published: March 2022

Dementia has rapidly become a major global health crisis. As the aging population continues to increase, the burden increases commensurately on both individual and societal levels. The behavioral and psychological symptoms of dementia (BPSD) are a prominent clinical feature of Alzheimer’s disease and related dementias (ADRD). BPSD represent a myriad of manifestations that can create significant challenges for persons living with dementia and their care providers. As such, BPSD can result in detriments to social interaction with others, resulting in harm to the psychosocial health of the person with dementia. While brain deterioration can contribute to BPSD as the disease progresses, it may be confounded by language and communication difficulties associated with ADRD. Indeed, when a person with dementia cannot effectively communicate their needs, including basic needs such as hunger or toileting, nor symptoms of pain or discomfort, it may manifest as BPSD. In this way, a person with dementia may be attempting to communicate with what little resources are available to them in the form of emotional expression. Failing to recognize unmet needs compromises care and can reduce quality of life. Moreover, failing to fulfill said needs can also deteriorate communication and social bonds with loved ones and caregivers. The aim of this review is to bring the differential of unmet needs to the forefront of BPSD interpretation for both formal and informal caregivers. The overarching goal is to provide evidence to reframe the approach with which caregivers view the manifestations of BPSD to ensure quality of care for persons with dementia. Understanding that BPSD may, in fact, be attempts to communicate unmet needs in persons with dementia may facilitate clinical care decisions, promote quality of life, reduce stigma, and foster positive communications.
Lockdown Impact on Stress, Coping Strategies, and Substance Use in Teenagers
Authors: Bourduge Cédrine , Teissedre Frédérique , Morel Florence , Flaudias Valentin , Izaute Marie , Brousse Georges
Published: March 2022

Background

In response to the COVID-19 pandemic, the French government took many measures, the most notable of which was a national lockdown on 17 March 2020. Its effects have been widely studied, but to our knowledge, no study has sought to determine how adolescents have adapted to cope with this situation. The present study set out to explore teenagers' stress levels, coping strategies, and substance use during this period.

Methods

This paper is a cross-sectional study that rides on an existing prevention program interviewed 348 French middle school students (209 girls and 139 boys) in grade 8 (Mage = 13.45; SDage = 0.54) using an online questionnaire between March 17 and May 11, 2020 (COVID-19 lockdown). The study examined the teenagers' perceived stress, coping strategies they had used, including recent use of tobacco, alcohol and cannabis, during COVID-19 lockdown.

Results

Teenagers reported lower perceived stress during lockdown than usually, with a significant decrease for girls. Those who perceived the least social support reported the highest levels of stress. The strategies of planning, behavioral disengagement, self-distraction, positive reframing, acceptance, and religion were used more than usual, while active coping and self-blame were used less. Acceptance was the most often used strategy and a source of decreased stress during lockdown. A significant decrease in recent tobacco, alcohol and cannabis use was also observed.

Conclusion

Changes in the use of coping strategies, withdrawal from the stressful school environment, and greater exposure to parents than to peers caused adolescents to be less stressed and to decrease their substance use during the lockdown.
The Oral-Microbiome-Brain Axis and Neuropsychiatric Disorders: An Anthropological Perspective
Authors: Bowland Grace B. , Weyrich Laura S.
Published: March 2022

In the 21st century, neuropsychiatric disorders (NPDs) are on the rise, yet the causal mechanisms behind this global epidemic remain poorly understood. A key to these unknowns may lie within the vast communities of bacteria, fungi, and viruses in the body (microbiota), which are intimately linked with health and disease. NPDs were recently shown to be connected to gut microbiota, which can communicate with and influence the brain through the Gut-Brain-Axis (GBA). Parallel studies examining oral microbiota and their connections to the brain also suggest that microbes in the mouth can similarly influence NPD outcomes. However, the mechanisms and pathways that illuminate how oral microbiota and brain communicate in NPDs remain unknown. Here, we review identified mechanisms and pathways that oral microbiota use to engage the brain, and we lay the theoretical foundation for an oral-microbiota-brain axis (OMBA). Specifically, we examine established neuroinflammatory and immune system activation responses that underpin interactions between the oral microbiota and the central nervous system (CNS), detailing four specific mechanisms: (1) microbial and metabolite escape, (2) neuroinflammation, (3) CNS signaling, and (4) response to neurohormones. We then scrutinize why including the OMBA, in addition to the GBA, is critically needed to elucidate specific causal relationships between microbial dysbiosis and observed NPD development and progression. Furthermore, we argue for comprehensive, interdisciplinary approaches that integrate lab-based microbiome research and population-level studies that examine the OMBA to improve NPDs. We specifically identify key anthropological perspectives that integrate sociocultural, epidemiological, genetic, and environmental factors that shape the oral microbiome and its interactions with NPDs. Together, future studies of the OMBA in conjunction with interdisciplinary approaches can be used to identify NPD risks and improve outcomes, as well as develop novel intervention and treatment strategies.
Differences in the Awareness and Knowledge of Radiological and Nuclear Events Among Medical Workers in Japan
Authors: Ochiai Kanae , Oka Tomo , Kato Nagisa , Kondo Yuji , Otomo Yasuhiro , Swienton Raymond E.
Published: March 2022

Background

Previous research revealed a lack of comfort and knowledge regarding nuclear and radiological events among medical staff. We investigated the awareness and knowledge of radiological and nuclear events among the Japanese medical staff by comparing differences by occupation (doctors, nurses, and other medical specialists).

Methods

We conducted a cross-sectional questionnaire survey among trainees undergoing Japanese disaster medical training courses between July 2014 and February 2016. The differences by occupation were evaluated for all questions on awareness and knowledge concerning disasters or radiological and nuclear events and demographics.

Results

Among the occupations, there were significant differences in the willingness to work onsite based on the types of disaster, familiarity with the national disaster medical response system, the accuracy rate of some knowledge about medical practice and the risk, and demographic characteristics such as practical experience and educational degree. The accuracy rates of responses to some questions on knowledge were very low in all occupations.

Conclusion

There were significant differences in awareness and knowledge of radiological and nuclear events by occupation. We believe that the results can be used to develop and modify the content of training courses on radiological and nuclear events to make such courses beneficial for each healthcare worker.
Risk Adjustment in Home and Community Based Services Outcome Measurement
Authors: Houseworth James , Kilaberia Tina , Ticha Renata , Abery Brian
Published: March 2022

The purpose of this study was to review and evaluate existing research that used risk adjusters in disability research. Risk adjustment controls for individual characteristics of persons when examining outcomes. We have conducted a systematic review and an evaluation of existing studies that included risk adjusters for outcomes of people with disabilities receiving services (home or community based). The process included coding each study according to the type(s) of risk adjusters employed and their relation to the specific population and outcomes within a framework. Panels were utilized to prioritize the risk adjusters. Findings indicate that four risk adjusters can be tentatively recommended as potential candidate risk adjusters: chronic conditions, functional disability, mental health status, and cognitive functioning. Holistic Health and Functioning far outweighed other outcomes studied to date. Further, there is a need for testing recommended risk adjusters across multiple outcomes and different populations of people with disabilities.
Lessons Learnt From the Experiences of Primary Care Physicians Facing COVID-19 in Benin: A Mixed-Methods Study
Authors: Bello Kéfilath , De Lepeleire Jan , Agossou Christian , Apers Ludwig , Zannou Djimon Marcel , Criel Bart
Published: March 2022

Introduction

In sub-Saharan Africa, there is a need to better understand and guide the practice of primary care physicians (PCPs), especially in a crisis context like the COVID-19 pandemic. This study analyses the experiences of PCPs facing COVID-19 in Benin and draws policy lessons.

Methods

The study followed a fully mixed sequential dominant status design. Data were collected between April and August 2020 from a sample of PCPs in Benin. We performed descriptive analyses on the quantitative data. We also performed bivariate analyses for testing associations between various outcomes and the public/private status of the PCPs, their localization within or outside the cordon sanitaire put in place at the beginning of COVID-19, and their practice' category. A thematic content analysis was done on qualitative data. Results from both analyses were triangulated.

Results

Ninety PCPs participated in the quantitative strand, and 14 in the qualitative. The median percentage of the COVID-19 control measures implemented in the health facilities, as reported by the PCPs, was 77.8% (interquartile range = 16.7%), with no difference between the various groups. While 29.4% of the PCPs reported being poorly/not capable of helping the communities to deal with COVID-19, 45.3% felt poorly/not confident in dealing with an actual case. These percentages were bigger in the private sector. The PCP's experiences were marked by anxiety and fear, with 80.2% reporting stress. Many PCPs (74.1%) reported not receiving support from local health authorities, and 75.3% felt their concerns were not adequately addressed. Both percentages were higher in the private sector. The PCPs especially complained of insufficient training, insufficient coordination, and less support to private providers than the public ones. For 72.4 and 79.3% of the PCPs, respectively, the pandemic impacted services utilization and daily work. There were negative impacts (like a decrease in the services utilization or the quality of care), but also positive ones (like improved compliance to hygiene measures and new opportunities).

Conclusion

Our study highlighted the need for more structured support to PCPs for optimizing their contribution to epidemics control and good primary healthcare in Benin. Efforts in this direction can build on several good practices and opportunities.
Justice and the Pandemic City: How the Pandemic Has Revealed Social, Urban, and Data Injustices, and How a Narrative Approach Can Unlock Them
Authors: Gulsrud Natalie Marie , Steiner Henriette
Published: March 2022

The global COVID-19 pandemic has exacerbated infrastructural, societal, and resource inequalities along racial and socioeconomic lines. Many countries have struggled to provide adequate COVID testing and healthcare. Denmark has been exceptional in its investment in a hyper-efficient and ever-present infrastructure, with testing tents distributed across the country. In this article we ask: What is the impact of this infrastructure in terms of the (urban) culture that is built around testing? And what does that mean in terms of data management and mass surveillance? As a public good, the COVID-19 testing infrastructure has costs and benefits, but these are not always clear. They concern future urban life and data management, and our ability to draw a boundary around ourselves—that is, biopolitics. At the time of writing, with the Omicron variant on the rise, we are hovering on the threshold between new restrictions and a post-COVID urban reality. Now is the time to take stock of the COVID infrastructure's spatial, temporal, and political dimensions, and of what they mean for urban decision-making, governance, justice, and democracy. To do so, and following philosopher and legal scholar Martha Nussbaum, we suggest the deployment of a narrative approach for the education of democratic citizenship and, indeed, for justice.
Optimizing Smallholder Farmers' Productivity Through Crop Selection, Targeting and Prioritization Framework in the Limpopo and Free State Provinces, South Africa
Authors: Kephe Priscilla Ntuchu , Siewe Lendeu Constantain , Lekalakala Ratunku Gabriel , Kwabena Ayisi Kingsley , Petja Brilliant Mareme
Published: March 2022

Smallholder farmers like those in Limpopo and the Free State (FS) Province of South Africa sometimes incur high production costs due to their crop choices. This cost is exacerbated by the challenges posed by climate change and the socio-economic position of the smallholder farmers. The opportunity cost of producing cost-intensive crops is the forgone benefits these smallholder farmers would have gained if they grew cheaper options. Therefore, a tool to assist farmers and stakeholders when choosing, advising on, or assisting with production and management decisions at farm levels to ensure profitability and sustainability is needed. This paper aimed at providing a framework to assist farmers in identifying profitable crops for production under the present day and possible future scenarios in Limpopo and the FS. This framework uses a multi-stage process with forward and backward linkages to refine analysis and results. Through reviews, interviews, focus groups and transect walks, the state of the biophysical, socio-economic, and political environment and their impact on smallholder farming were collected from 600 farmers and 40 key informants. Inferential statistics and cost-benefit analysis were used for data analysis. The results indicate that maize, though widely cultivated in both Provinces, has the highest average total production cost of R 29,694.39 /ha while the lowest was sunflower with R 6,453.78 /ha. Irrigated maize had the highest break-even price per hectare of R 38 351.85, while sunflower had the lowest R 4 685.85. In both provinces, groundnut ranked first on Net Present Value (NPVs) at discount rates of 8% and 10%, while low yield maize ranked last, scoring values of –R 4 163 894 and –R 3 953 393. Groundnut had the highest Benefit Cost Ratio (BCR) at 2.22 and 6.70 in Limpopo and FS. The BCR for low-yield maize was the lowest of all the crops. The base scenario results in economic and financial terms indicate it is better to farm sunflower, soybean, grain sorghum, and groundnuts than maize because of lower production cost and maize substitutes. Furthermore, climate change projections suggest a drier future for these provinces, implying the yield targets for farmers producing maize would be difficult to achieve when faced with climate change. Such information is vital for stakeholders.
Reduced Milk Production, Economic Losses, and Risk Factors Associated to Subclinical Hypocalcemia in Holstein Friesian × Zebu Crossbreed Cows in North-West Ethiopia
Authors: Mekonnen Sefinew Alemu , Alelgn Zegeye , Saudik Seid , Molla Wassie , Fentie Tsegaw , Jemberu Wudu Temesgen
Published: March 2022

Hypocalcemia is a metabolic disorder that occurs when calcium leaves the blood to support milk production or for the growth of the fetus faster than calcium can be put back into the blood. Subclinical hypocalcemia (SCH) refers to clinically normal cows but with concentrations of calcium lower than measured in normal cows. A study was conducted to estimate economic losses and to identify risk factors associated with SCH in Holstein Friesian × Zebu crossbreed Cows in North-West Ethiopia. A total of 221 lactating dairy cows obtained from 81 dairy farms were selected and serum samples were collected and analyzed to estimate the level of calcium in the serum using an automated electrolyte analyzer (Roch, UVL Japan, 2014). Forty-seven cows obtained from 12 farms were grouped into two: cows with SCH and cows without SCH and milk yield was measured for eight consecutive days to estimate milk production loss associated with SCH. Prevalence was estimated and univariable and multivariable logistic regression analyses were used to identify determinants of SCH. The prevalence of SCH was 20.3% (51/221, 90% CI = 18.6%−28.1%). Grazing on pasture, membership to dairy cooperative, feeding above the cows' requirement (based on farmers' opinion), and previous experience of metritis reduced the odds of SCH (P < 0.05). The average economic losses associated with reduced milk production due to SCH were 11.25 Ethiopian Birr (ETB) (1 ETB = 0.023 US Dollar) and 3,026.25 ETB (69.6 US Dollar) per cow per lactation, respectively. The main findings of the study have shown that SCH was a problem in crossbreed dairy cows in Northwestern Ethiopia and identified few risk factors that could be targeted to mitigate the problem. Actually, in this study, the economic cost of SCH was significant and needs attention in the dairy extension and dairy health training programs.
Phase Change Cooling of a Metal Hydride Reactor for Rapid Hydrogen Absorption
Authors: Keith Matthew Duncan , Kukkapalli Vamsi Krishna , Kim Sunwoo
Published: March 2022

As the world is keen on cleaner and sustainable energy, hydrogen energy has the potential to be part of the green energy transition to replace fossil fuels and mitigate climate change. However, hydrogen energy storage is a difficult task since physical storage in the form of compressed gas under high pressure is associated with safety issues. Another form of hydrogen storage is material-based storage, which is the safest way to store hydrogen energy in a particulate matter, known as metal hydrides. Metal hydrides can store hydrogen at room temperature and use less volume to store the same amount of hydrogen compared to classical gas tanks. The challenges with the metal hydrides reactor are their slow charging process and the requirement of proper thermal management during the charging process. In this study, a metal hydride reactor model is developed in COMSOL Multiphysics, and the associated heat transfer simulations are performed. The main objective of this research is to optimize the cooling channel design in the metal hydride reactor, where the R-134a coolant rejects heat through both latent and sensible heat transfer. The study showed that the phase-changing coolant and varying convection coefficient along the length of tubes significantly reduce the hydrogen charging time and the peak temperature of the reactor during hydrogen absorption. The pumping power analysis for the R-134a flow was also conducted. The computation results reveal that coolant channel configurations with nine or more tube-passes require significantly large pumping power.
Scientific and Ethical Aspects of Identified Skeletal Series: The Case of the Documented Human Osteological Collections of the University of Bologna (Northern Italy)
Authors: Belcastro Maria Giovanna , Pietrobelli Annalisa , Nicolosi Teresa , Milella Marco , Mariotti Valentina
Published: March 2022

Osteological collections are an essential source of information on human biological and cultural variability, providing insights about developmental, evolutionary, and biocultural processes. Among osteological series, documented human osteological collections (DHOC) are especially useful due to the opportunity to control biological parameters such as age-at-death and sex, which are typically unknown in archaeological or forensic cases. Raising ethical concerns about the collection, management, and study of human remains poses anthropologists with renewed responsibilities. These issues become especially pressing when dealing with DHOC. In this contribution, we discuss the scientific value and ethical issues characterizing DHOC using as case study the documented human osteological collections of the University of Bologna. This series includes more than 1000 individuals from Northern Italian and Sardinian cemeteries and is among the largest in Europe. It represents the basis for ongoing research on a large range of methodological studies, especially focused on the reconstruction of biological profile. After outlining the scientific studies performed on this DHOC, we discuss it in the context of the specific legislation featuring the Italian territory. Finally, we highlight some directions where work can be carried out to better balance scientific research, preservation needs, and ethical concerns, stressing the advantages of modern imaging techniques.
Contact-Induced Change in the Domain of Grammatical Gender in Pontic Greek Spoken in Georgia
Authors: Berikashvili Svetlana
Published: March 2022

This paper presents an empirical study on the cross-linguistic influence of contact languages (Turkish, Georgian and Russian) in the domain of grammatical gender in Pontic Greek spoken by the Pontic-speaking community of Georgia. The study is based on corpus data collected during several periods of fieldwork within the Pontic-speaking community of Georgia. The questions addressed in the paper are: What innovations can be observed in the understudied variety in the gender domain, and, if any innovation is observed, are they due to the impact of contact languages? I argue that contact-induced changes in the gender domain manifest themselves in the assignment of gender to loan nouns, and contribute to the establishment of the default gender value. The main findings reveal that, in comparison with other Pontic varieties, this variety is on the one hand more sensitive to the animacy hierarchy, and, on the other, shows increased use of the feminine gender as a result of the incorporation of feminine loans from a gendered language, i.e., Russian.
Masturbation Frequency and Sexual Function in Individuals with and without Sexual Partners
Authors: Huang Sijia , Niu Caoyuan , Santtila Pekka
Published: March 2022

The aim of this study was to investigate the association between masturbation frequency and sexual dysfunction among men and women, focusing on individuals with and without regular sexual partners, and to determine whether sexual compatibility (e.g., similar sexual desire levels and a match between desired behaviors and behaviors one’s partner is willing to engage in) in the relationship affects masturbation frequency. Here, 12,271 Finnish men and women completed an online survey about masturbation frequency, sexual function, and sexual compatibility with their partner for those who were in a relationship. The results indicated that masturbation frequency was positively associated with overall sexual function for women. This was moderated by relationship status, meaning that more frequent masturbation was associated with better orgasmic function and sexual satisfaction in single women, whereas the opposite was true for women who were in a relationship. For men, more frequent masturbation was associated with better erectile function for single men, and better ejaculatory latency but worse orgasmic function, intercourse satisfaction, and more symptoms of delayed ejaculation for men who were in a relationship. Lower sexual compatibility and sexual dysfunctions in the partner were associated with more frequent masturbation in both sexes. The associations between masturbation frequency and sexual function vary for single and partnered individuals, and are, for the latter group, further affected by sexual compatibility.
Caecal Volvulus: A District General Hospital Experience and Review of the Literature
Authors: Pangeni Anang , Chowdhury Ashim , Rai Sujata , Colledge Jann Yee , Shrestha Ashish Kiran
Published: March 2022

Background: Caecal volvulus (CV) is an uncommon cause of large bowel obstruction with potential for complications such as ischaemia and perforation. Prompt diagnosis and treatment only will ensure better outcomes. We aim to describe our experience in the largest series of CV reported in the United Kingdom. Methods: This was a retrospective study of 16 consecutive patients diagnosed with CV between March 2017 and March 2020. Results: Out of 16 patients, 11 were female, with a median age of 64 (range 33–80) years. All patients presented with abdominal pain and vomiting. An initial diagnosis of bowel obstruction was made only in 8 patients (50%). Computed tomography (CT) scan of the abdomen and pelvis correctly diagnosed CV in fourteen (87.5%). Fifteen patients (94%) underwent surgical intervention. All but one (n = 14, 93.4%) underwent laparotomy, and one patient (6.6%) underwent successful laparoscopic intervention. Right hemicolectomy was performed in all operated patients, and fourteen patients (93.4%) had primary anastomosis. Twelve patients (80%) had one or another form of morbidity. Seven patients (47%) and three patients (20%) had grade II and III (Clavien–Dindo Classification) complications, respectively, with a median hospital stay of 10 (range 1–49) days. One patient (6.7%) managed conservatively was deemed to be futile. There was no postoperative mortality. Conclusions: CV can present with non-specific symptoms, and a definite preoperative diagnosis is only possible with the aid of CT. Open resectional procedures with primary anastomosis are the most favoured approach in management, though laparoscopic access is also feasible in fit patients.
Assessment and modeling of volatility in the Russian stock market: empirical study
Authors: Lukasevich I.
Published: March 2022

The work is devoted to an empirical study of volatility in the Russian stock market. The indicators of volatility assessment are considered, approaches to its assessment and modeling are analyzed. Based on the values of the stock indices MOEX10 and MOEXBMI for a ten-year period from 2012 to 2021, various indicators of their volatility were determined, its properties and features were identified. Econometric models are proposed that describe the behavior of the volatility of the MOEX10 and MOEXBMI indices and allow for short-term and long-term forecasting of their values. The indicators, models and approaches used in this article can be used by investors to assess and predict risks when conducting transactions in the stock market.
EMIL FROESCHEL'S CONTRIBUTION TO THE DEVELOPMENT OF SPEECH THERAPEUTIC SCIENCE AND PRACTICE
Authors: BEREZAN V.
Published: March 2022

The article presents the figure of the prominent Austrian scientist Emil Froeschels, who introduced the term “logopedics” into clinical practice, is considered the founder of speech pathology (speech therapy) education, founded the world's first International Association of Logopedics and Phoniatrics (IALP) and a number of other national associations and unions. The article focuses on his leadership qualities as a scientist, teacher and public figure. On the basis of the research the directions of researches of the scientist are defined: problems of speech therapy (stuttering, aphasia, dysarthria, etc.), speech and voice therapy, methodical materials and the analysis of comparative researches, researches of physiology and problems of speech and voice and speech organs, philosophical researches, questions speech psychology, problems of education, training and upbringing of children with and without disabilities, phonetic observations, etc. The methods of speech pathology (speech therapy) work with the patient proposed by E. Froeschels, which were introduced into clinical practice, are analyzed.
PSYCHOLOGICAL AND PEDAGOGICAL ASPECTS OF LANGUAUGE TRAINING IN THE STUDY OF BIOLOGICAL DISCIPLINES BY FOREIGN STUDENTS
Authors: OVCHARENKO O. , KUSHPIL N. , KOLECHKINA I.
Published: March 2022

The article analyzes the key aspects of psychological and pedagogical features of language training in the study of biological disciplines by foreign students of The Educational and Research Center for Foreign Citizens Training of Poltava State Medical University. The basic issues of studying the language of biological disciplines as a tool of psychological and pedagogical adaptation of foreign students to the Ukrainian educational environment are outlined. The main problems that cause an unfavourable level of adaptive capacity of foreign students to the educational process at the propaedeutic stage are revealed. The authors prove the effectiveness of taking into account the individual speech competencies of foreigners as a basis for further professional training in the favourable educational environment. The main problems that determine the proper level of adaptive capacity of foreign students to the educational process at the propaedeutic stage are identified: low level of speech competence, insufficient level of knowledge of natural sciences, lack of motivation of most foreigners to study natural sciences. Based on experience, measures to overcome these problems are presented. Research is guided by the principles of communicative methods and based on interdisciplinary coordination. There are adapted textbooks in natural sciences in Ukrainian / Russian / English, multilingual dictionaries, guidelines for laboratory work with recommendations for generalization and systematization of knowledge. In order to form an internal motivation to learn and establish effective cooperation and understanding in the group, an individual approach to each student is taken into account.
ANALISIS	ISO 9001:2015 PT PANCA BINTANG TUNGGAL SEJAHTERA DENGAN MENGGUNAKAN METODE GAP ANALYSIS
Authors: Primasanti Yunita , Hendratmoko Rachmat
Published: March 2022

Large and medium scale companies wish to obtain ISO 9001: 2015 certificate to improve management quality. PT Panca Bintang Tunggal Sejahtera has made preparations for the implementation of quality management. Before applying for the certification process, the company has implemented and is currently reviewing the implementation of its quality management system so that the certification process can run well so that the certificate can be obtained. To analyze the level of implementation of the quality management system in the company used the GAP analysis checklist method. This analysis uses several indicators. Furthermore, interviews were conducted with each director who served in the company to determine the obstacles in the application of the quality management system. The results of the GAP analysis checklist show that the implementation of the ISO 9001: 2015 quality management system in the company is good but still requires improvement in several clauses. The percentage of the assessment shows that clause 9 (performance evaluation) is the clause with the lowest score with a value of 60.25%, while the highest percentage is in clause 5 (leadership) with a score of 81.29%. The main obstacle faced by the company is the level of understanding of the implementation of the new system is still lacking and the performance of some individuals is not optimal. Companies must be more intense in monitoring the performance of each unit to improve their quality management system so that the certification process can run smoothly.
Myotonic Dystrophy of Rossolimo – Curschmann – Steinert – Batten: Own Clinical Observation and Features of Differential Diagnosis
Authors: Яровая К.А. , Солодовникова Ю.А. , Дрибина С.И. , Сон А.С.
Published: March 2022

Миотоническая дистрофия (МД) Россолимо – Куршманна – Штейнерта – Баттена, или тип 1, – наследственное аутосомно-доминантное заболевание с сочетанием миотонического, миопатического синдромов и мультисистемных проявлений и феноменом антиципации. МД была описана несколькими авторами: Г.И. Россолимо (1901 г.), F.F. Batten, H. Curschmann, H. Steinert (1909 г.). Заболевание чаще проявляет себя на 2–4-м десятилетиях жизни. В начале болезни миотония превалирует над миодистрофией, но по мере прогрессирования дистрофии миотонический компонент становится менее заметным. Пациенты имеют характерный фенотип из-за лобной алопеции, двустороннего птоза, «губ тапира», амимии, атрофии мимических, височных, жевательных мышц, грудино-ключично-сосцевидных мышц. К другим неврологическим симптомам относятся сомноленция в дневное время, прогрессирующий когнитивный дефицит, дизартрия, отсутствие ахилловых и коленных рефлексов, атаксия; атрофия мышц дистальных отделов ног, со временем распространяющаяся на кисти, степпаж. МР-признаки в головном мозге неспецифичны и включают в себя умеренную корковую атрофию и вентрикуломегалию, диффузные двусторонние повреждения белого вещества в лобно-теменной и передней височной областях. К системным признакам относят раннюю субкапсулярную катаракту, нарушения сердечного ритма и проводимости, расстройства дыхания, гастроэзофагеальную рефлюксную болезнь, эндокринные нарушения, костные изменения.

Myotonic dystrophy (MD) of Rossolimo – Kurshman – Steinert – Batten or type 1 is a hereditary autosomaldominantdiseasewithacombinationofmyotonic, myopathicsyndromesandmultisystem manifestations and the phenomenon of anticipation. MD has been described by several authors:G.I. Rossolimo (1901), F.F. Batten, H. Curschmann, H. Steinert (1909). The disease often manifestsin the 2nd-4th decades of life. At the onset of the disease, myotonia prevails over myodystrophy, but as dystrophy progresses the myotonic component becomes less noticeable. Patients have a characteristic phenotype due to frontal alopecia, bilateral ptosis, tapir mouth, amimia, atrophy of the facial, temporal, and masticatory muscles, sternocleidomastoid muscles. Other neurological symptoms include daytime somnolence, progressive cognitive deficiency, dysarthria, absence of Achilles and knee reflexes, ataxia; distal muscular dystrophy of legs, eventually spreading to the hands, steppage. MR signs in the brain are nonspecific and include moderate cortical atrophy and ventriculomegaly, diffuse bilateral lesions of white matter in the frontoparietal and anterior temporal regions. Systemic signs include early subcapsular cataracts, cardiac arrhythmias and conduction disorders, respiratory disorders, gastroesophageal reflux disease, endocrine diseases, bone changes.
Limb-Girdle Muscular Dystrophy Type 2A (Leiden- Möbius Phenotype) with Compound Heterozygous Mutationin 4 Exon of CAPN3 Gene: Own Observation
Authors: Рушкевич Ю.Н. , Мальгина Е.В. , Куликова С.Л. , Лихачев С.А. , Мирзоян А.Р.
Published: March 2022

В статье приведено описание собственного наблюдения генетически подтвержденного случая конечностно-поясной мышечной дистрофии (КПМД) 2А типа (фенотип Лейдена – Мебиуса). По клиническим признакам различные типы КПМД крайне трудно дифференцировать между собой. КПМД являются примером, когда мутации разных генов, локализованных в разных хромосомах, кодирующих разные белки, приводят к развитию сходных клинических фенотипов. Кальпаинопатия является наиболее распространенной формой КПМД и характеризуется значительным клиническим полиморфизмом и тяжестью заболевания. Установить точный диагноз позволяет молекулярно-генетическое исследование, которое должно быть рекомендовано в случае наличия типичных клинических проявлений, а также при выявлении высоких цифр сывороточной креатининфосфокиназы. В последнее десятилетие достигнуты значительные успехи в изучении молекулярных механизмов наследственных нервно-мышечных заболеваний. Важным аспектом является вопрос планирования детей и необходимость молекулярно-генетического исследования супругов пациентов для оценки риска рождения больного ребенка.

The article describes own observation of a genetically confirmed limb-girdle muscular dystrophy type 2A (Leiden- Möbius phenotype). According to clinical signs, various types of CPMD are extremely difficult to differentiate between themselves. LGMD’s are an example where mutations of different genes located in different chromosomes encoding different proteins lead to the development of similar clinical phenotypes. Calpainopathy is the most common form of LGMD and is characterized by significant clinical polymorphism and severity of the disease. It is possible to establish an accuratediagnosis of molecular genetic study, which should be recommended in case of typical clinical manifestations, as well as in case of detection of high figures of serum CK. Significant advances have been made over the past decade in the study of the molecular mechanisms of hereditary neuromuscular diseases. An important aspect is child planning issues and the need for molecular genetic research of patient spouses to assess the risk of having a sick child.
Pengaruh Sistem Produksi Dan Peran Penyuluh Pertanian Terhadap Keberhasilan Usahatani Jamur Tiram Putih (Pleurotus ostreatus)
Authors: Sumarga Amar Romidin , Dasipah Euis , KS Karyana
Published: March 2022

This study aims to find out the relationship between the Production System And Role of Agricultural Extensionists on the Success of White Oyster Mushroom Farming (Pleurotus Ostreatus).    The analysis unit is farmers of White Oyster Mushroom Farming. The technique of determining respondents was carried out in a census of 60 units. Analysis techniques are used pearson correlation and path analysis. The results of the study obtained by the production system in the business activities of white oyster mushrooms inCugenangSubdistrict are characterized at the level of application of white oyster mushroom cultivation technology consisting of dimensions: from the process of providing raw materials; production process; harvesting and post-harvest handling; Distribution and warehousing obtained a rate of achievement of 78.87 % good criteria. The role of PPL is related to the business activities of white oyster mushrooms inCugenangSubdistrict which consists of dimensions: Advisors; Technicians; Liaison; Organizer;  and innovators obtained a level of achievement of 77.01 % good criteria. The success of the white oyster mushroom farming business inCugenangSubdistrict consisting of dimensions: productivity; product quality; continuity ; and farming efficient . Obtained a level of achievement of 77.50 % good criteria. There is a strong relationship between the role of PPL and the production system in the white oyster mushroom farming business inCugenangSubdistrict, indicated by the correlation coefficient r = 0.93.  The better the role of PPL, the better the production system.    The production system and the role of PPL have a positive effect on the success of white oyster mushroom farming inCugenangSubdistrict.  Production System contribution was obtained 81,23 % and contribution of PPL Role 12.60 %.
¿Fue golpe? Pulsando el debate sobre la supuesta fascistización de Bolivia
Authors: Archondo Rafael
Published: March 2022

El 10 de noviembre de 2019, Evo Morales, presidente de Bolivia durante los últimos 14 años, entregaba su carta de renuncia después de un largo período de protestas iniciado después de las elecciones generales del 20 de octubre, atravesadas por acusaciones de fraude. Dejaba a Bolivia sumida en un vacío de poder que tardó dos días en ser llenado con la conformación de un gobierno transitoriodescrita por la prensa como un golpe de Estado a la democracia. ¿Fue un golpe? El presente artículo evalúa minuciosamente las dos argumentaciones, hace un seguimiento de los cambios de gobierno en Bolivia durante los últimos 87 años y cataloga los hechos ocurridos en 2019 desde una perspectiva comparada. El objetivo es tratar de etender si democracia boliviana está en agonía o restablecida y si las tendencias hacia la fascistización del país son una realidad o un mito
Intraoperative radiation therapy in the treatment of breast cancer. From the past to the future
Authors: Chumachenko I. S. , Murashko R. A. , Keshabyan A. A.
Published: March 2022

This article discusses the experience of using intraoperative radiation therapy in the treatment of patients with breast cancer, as well as the prospects for the development of this area in terms of benefits (improved therapy effect, reduced severity of side effects, no effect on adjacent organs) and risks (the possibility of local recurrence) for patients.
GANTI KERUGIAN IMMATERIIL TERHADAP PERBUATAN MELAWAN HUKUM DALAM PRAKTIK: PERBANDINGAN INDONESIA DAN BELANDA
Authors: Mantili Rai
Published: March 2022

Pasal 1365 KUHPerdata menyatakan bahwa perbuatan melawan hukum yang membawa kerugian kepada seorang lain, mewajibkan orang yang karena salahnya menerbitkan kerugian itu, mengganti kerugian tersebut. Rumusan mengenai perbuatan melawan hukum tidak dijelaskan dan hanya memberikan dasar pengajuan ganti kerugian berdasarkan perbuatan melawan hukum. Bentuk-bentuk kerugian pada perkara perbuatan melawan hukum biasanya terdiri atas dua bentuk, yakni kerugian materiil dan kerugian immateriil. Metode penelitan dalam penelitian ini yaitu yuridis normatif. Melalui penelitian yang dituangkan dalam bentuk artikel ini diharapkan konsep ganti kerugian immateriil di Indonesia dapat terbentuk agar tercipta kepastian hukum dalam suatu putusan pengadilan. Hasil penelitian menegaskan bahwa ketiadaan pengaturan mengenai kompensasi ganti kerugian immateriil perbuatan melawan hukum menyebabkan perbedaan penafsiran yang berbeda-beda pada putusan hakim. Hal yang akan diuraikan dalam artikel ini adalah mengenai pengaturan ganti kerugian immateriil pada perkara perbuatan melawan hukum dalam praktik di Indonesia dan mengenai pengaturan ganti kerugian immateriil pada perbuatan melawan hukum di Belanda.