bluuebunny/crossref_metadata_2025 huggingface dataset:
Overlying Suture Causes Chondrolysis in Surgical Treatment of Acute Bony Bankart Lesions
Authors: Greenstein Alexander , Brown Alexander M. , Roberts Aaron , Chen Raymond Edward , Knapp Emma , Rao Pranay , Voloshin Ilya
Published: July 2019

Objectives:

Severe cartilage loss has been described in the setting of shallow anchor placement in arthroscopic shoulder surgery. There has been no previous investigation into the effects of cartilage loss due to suture from suture anchors overlying the repaired bony fragment. Current arthroscopic techniques for bony Bankart repair involve placement of suture overlying articular cartilage. We hypothesize there will be cartilage loss over time due to the presence of suture from suture anchors in acute bony Bankart repairs, and double-row reconstruction will cause increased humeral head cartilage loss due to an overall larger surface area when compared to single-row reconstruction.

Methods:

Testing was performed on 24 cadaveric glenoids, 12 right and 12 left, with simulated bony Bankart fractures with a defect width of 25% of the glenoid diameter. Half of the fractures were repaired with a double-row technique, while the contralateral glenoids were repaired with a single-row technique. Samples were randomized by blinded envelopes. Samples were subjected to 20,000 cycles of internal-external rotation across a 90o arc at 2 Hz after a compressive load of 750-N or 90% BW, whichever was less, was applied to simulate wear. Cartilage defects were quantified through a custom MATLAB script. Images were excluded for poor quality, or inadvertent tissue folding during tissue processing. Mean cartilage cutout differences were analyzed by Wilcoxon Rank Sum Test.

Results:

A total of 92 images were analyzed, 51 double-row and 41 single-row. The double-row technique resulted in significantly (p=0.027) more cartilage cutout (99,746.1 µm2, SD=65,864.8 µm2) than single row repair (mean=68,884.5 µm2, SD=44,373 µm2).

Conclusion:

Both the single-row and double-row fixation techniques resulted in damage to the humeral articular cartilage. The double-row fixation technique resulted in significantly increased chondrolysis to the humeral head after simulated wear in this cadaveric model. Despite the biomechanical superiority of double-row repair, surgeons must be aware of the increased rate of chondrolysis involved with this technique.
The Temporal Logic of Deservingness: Inequality Beliefs in Two Postsocialist Societies
Authors: Hilmar Till
Published: July 2019

Employing a cultural sociological approach, this article asks how individuals from two postsocialist societies articulate principles of justice by providing narrative accounts of other peoples’ perceived choices and social mobility trajectories after 1989. Using data from an interview study of 67 respondents from former East Germany and the Czech Republic, I present two interrelated findings: First, as respondents negotiate the tension between the principles of merit and need, they show widespread support for the idea that individuals are personally responsible for their fate despite the legacy of egalitarianism commonly associated with postsocialist societies. Second, individuals can effectively challenge the principle of merit by using a certain type of eventful knowledge about economic change after 1989 that is articulated morally but points to the limits of choice. The article distinguishes different notions of deservingness and contributes to the current debate on the links between culture and economics.
Estrogen signaling effects on muscle-specific immune responses through controlling the recruitment and function of macrophages and T cells
Authors: Liao Zhao Hong , Huang Tao , Xiao Jiang Wei , Gu Rui Cai , Ouyang Jun , Wu Gang , Liao Hua
Published: July 2019

Background

Estrogen signaling is indispensable for muscle regeneration, yet the role of estrogen in the development of muscle inflammation, especially in the intramuscular T cell response, and the influence on the intrinsic immuno-behaviors of myofibers remain largely unknown. We investigated this issue using the mice model of cardiotoxin (CTX)-induced myoinjury, with or without estrogen level adjustment.

Methods

CTX injection i.m. (tibialis anterior, TA) was performed for preparing mice myoinjury model. Injection s.c. of 17β-estradiol (E2) or estrogen receptor antagonist 4-OHT, or ovariectomy (OVX), was used to change estrogen level of animal models in vivo. Serum E2 level was evaluated by ELISA. Gene levels of estrogen receptor (ERs) and cytokines/chemokines in inflamed muscle were monitored by qPCR. Inflammatory infiltration was observed by immunofluorescence. Macrophage and T cell phenotypes were analyzed by FACS. Immunoblotting was used to assess protein levels of ERs and immunomolecules in C2C12 myotubes treated with E2 or 4-OHT, in the presence of IFN-γ.

Results

We monitored the increased serum E2 level and the upregulated ERβ in regenerated myofibres after myotrauma. The absence of estrogen in vivo resulted in the more severe muscle inflammatory infiltration, involving the recruitment of monocyte/macrophage and CD4+ T cells, and the heightened proinflammatory (M1) macrophage. Moreover, estrogen signaling loss led to Treg cells infiltration decrease, Th1 response elevation in inflamed muscle, and the markedly expression upregulation of immunomolecules in IFN-γ-stimulated C2C12 myotubes in vitro.

Conclusion

Our data suggest that estrogen is a positive intervention factor for muscle inflammatory response, through its effects on controlling intramuscular infiltration and phenotypes of monocytes/macrophages, on affecting accumulation and function of Treg cells, and on suppressing Th1 response in inflamed muscle. Our findings also imply an inhibition effect of estrogen on the intrinsic immune behaviors of muscle cells.
Insights into functional polymer-based organic-inorganic nanocomposites as leather finishes
Authors: Fan Qianqian , Ma Jianzhong , Xu Qunna
Published: July 2019

Nowadays, the increasing demands from consumer challenges the traditional leather products. Traditional polymer leather finishes gradually lose their dominant position in the market. To address this issue, recent research effort has been devoted to developing polymer-based organic-inorganic nanocomposite leather finishes due to their various functional properties including antibacterial, self-cleaning and water-resistant property. In this review, we provide a comprehensive overview of synthesis of polymer-based organic-inorganic nanocomposites and their application as functional leather finishes. With the perspective of their properties and current challenges, an outlook in the future development about crafting functional and high-quality leather finishes are further proposed.

Graphical abstract
Factors affecting mass transfer of protease in pelt during enzymatic bating process
Authors: Song Ying , Wu Siqi , Yang Qian , Liu Hao , Zeng Yunhang , Shi Bi
Published: July 2019

Bating pelt with protease is an important process, which removes unwanted non-collagenous proteins from the pelt and moderately disperse hide collagen network. However, the grain surface, may be excessively hydrolyzed during bating due to the longer retention time of protease in the grain than in the middle layer caused by the low mass transfer rate of protease in pelt. Here, the effects of protease dosage, common auxiliaries and molecular weight of protease on protease transfer during bating were investigated so that we can find the key points to avoid excessive collagen damage, particularly in the grain. Observably, increasing protease dosage led to faster protease transfer and softer leather, but along with more considerable grain damage. Using penetrating agent JFC (fatty alcohol-polyoxyethylene ether) and ammonium sulfate enhanced protease transfer and simultaneously alleviated collagen damage due to the decrease in interfacial tension and electrostatic attraction between protease and pelt, respectively. Additionally, proteases with lower molecular weight transferred faster in pelt, which suggests that a potential strategy to solve the conflict between the mass transfer and the reaction of protease in pelt might be to produce/employ smaller bating proteases.

Graphical abstract
Exploring patients’ and carers’ views about the clinical use of ketamine to inform policy and practical decisions: mixed-methods study
Authors: Jilka Sagar , Murray Claire , Wieczorek Ania , Griffiths Helena , Wykes Til , McShane Rupert
Published: July 2019

Background

Only one-third of patients with major depressive disorder achieve remission. One new and promising treatment, ketamine, may prove challenging to implement because of its abuse potential. Although clinicians' views have been sought, we need patients' views before large scale roll-out is considered.

Aims

To explore patients’ and carers' views to inform policy and practical decisions about the clinical use of ketamine.

Method

We carried out a mixed-methods study using data from 44 participants in 21 focus groups in three sessions and an online survey with patients, carers and advocates during a consultation day. Focus groups explored participant's views about ketamine as a form of treatment and the best way for ketamine to be prescribed and monitored. The qualitative data were analysed by two patient–researchers using an exploratory framework analysis and was supplemented by a survey.

Results

The ten themes generated were monitoring, information, effect on daily life, side-effects, recreational use, effectiveness, appropriate support, cost, stigma and therapy. Participants wanted better evidence on the safety of ketamine after long-term use and felt that monitoring was required. Collecting this information would provide evidence for ketamine's safe use and administration. There were, however, concerns about the misuse of this information. Practical issues of access were important: repeated travelling to clinics and a lack of sufficiently informed medical staff were key barriers.

Conclusions

Clinicians have some similar and some different views to those of patients, carers and advocates, which need to be considered in any future roll-out of ketamine.

Declaration of interest

R.M. has had UK National Institute for Health Research grant funding to study ketamine, is participating in trials of esketamine, runs a clinic that provides ketamine treatment, and has consulted for Johnson & Johnson and Eleusis.
Immunotherapy of Relapsed and Refractory Solid Tumors With Ex Vivo Expanded Multi-Tumor Associated Antigen Specific Cytotoxic T Lymphocytes: A Phase I Study
Authors: Hont Amy B. , Cruz C. Russell , Ulrey Robert , O’Brien Barbara , Stanojevic Maja , Datar Anushree , Albihani Shuroug , Saunders Devin , Hanajiri Ryo , Panchapakesan Karuna , Darko Sam , Banerjee Payal , Fortiz Maria Fernanda , Hoq Fahmida , Lang Haili , Wang Yunfei , Hanley Patrick J. , Dome Jeffrey S. , Bollard Catherine M. , Meany Holly J.
Published: July 2019

PURPOSE

Tumor-associated antigen cytotoxic T cells (TAA-Ts) represent a new, potentially effective and nontoxic therapeutic approach for patients with relapsed or refractory solid tumors. In this first-in-human trial, we investigated the safety of administering TAA-Ts that target Wilms tumor gene 1, preferentially expressed antigen of melanoma, and survivin to patients with relapsed/refractory solid tumors.

MATERIALS AND METHODS

TAA-T products were generated from autologous peripheral blood and infused over three dose levels: 1, 2, and 4 × 107 cells/m2. Patients were eligible for up to eight infusions administered 4 to 7 weeks apart. We assessed dose limiting toxicity during the first 45 days after infusion. Disease response was determined within the context of a phase I trial.

RESULTS

There were no dose-limiting toxicities. Of 15 evaluable patients, 11 (73%) with stable disease or better at day 45 postinfusion were defined as responders. Six responders remain without progression at a median of 13.9 months (range, 4.1 to 19.9 months) after initial TAA-Ts. Patients who were treated at the highest dose level showed the best clinical outcomes, with a 6-month progression-free survival of 73% after TAA-T infusion compared with a 38% 6-month progression-free survival with prior therapy. Antigen spreading and a reduction in circulating tumor-associated antigens using digital droplet polymerase chain reaction was observed in patients after TAA-T infusion.

CONCLUSION

TAA-Ts safely induced disease stabilization, prolonged time to progression, and were associated with antigen spreading and a reduction in circulating tumor-associated antigen DNA levels in patients with relapsed/refractory solid tumors without lymphodepleting chemotherapy before infusion. TAA-Ts are a promising new treatment approach for patients with solid tumors.
The Dystonias
Authors: Jinnah H. A.
Published: July 2019

PURPOSE OF REVIEW

This article provides a summary of the state of the art in the diagnosis, classification, etiologies, and treatment of dystonia.

RECENT FINDINGS

Although many different clinical manifestations of dystonia have been recognized for decades, it is only in the past 5 years that a broadly accepted approach has emerged for classifying them into specific subgroups. The new classification system aids clinical recognition and diagnosis by focusing on key clinical features that help distinguish the many subtypes. In the past few years, major advances have been made in the discovery of new genes as well as advances in our understanding of the biological processes involved. These advances have led to major changes in strategies for diagnosis of the inherited dystonias. An emerging trend is to move away from heavy reliance on the phenotype to target diagnostic testing toward a broader approach that involves large gene panels or whole exome sequencing.

The dystonias are a large family of phenotypically and etiologically diverse disorders. The diagnosis of these disorders depends on clinical recognition of characteristic clinical features. Symptomatic treatments are useful for all forms of dystonia and include oral medications, botulinum toxins, and surgical procedures. Determination of etiology is becoming increasingly important because the number of disorders is growing and more specific and sometimes disease-modifying therapies now exist.
Tics and Tourette Syndrome
Authors: Singer Harvey S.
Published: July 2019

PURPOSE OF REVIEW

The purpose of this article is to present current information on the phenomenology, epidemiology, comorbidities, and pathophysiology of tic disorders and discuss therapy options. It is hoped that a greater understanding of each of these components will provide clinicians with the necessary information to deliver thoughtful and optimal care to affected individuals.

RECENT FINDINGS

Recent advances include the finding that Tourette syndrome is likely due to a combination of several different genes, both low-effect and larger-effect variants, plus environmental factors. Pathophysiologically, increasing evidence supports involvement of the cortical–basal ganglia–thalamocortical circuit; however, the primary location and neurotransmitter remain controversial. Behavioral therapy is first-line treatment, and pharmacotherapy is based on tic severity. Several newer therapeutic agents are under investigation (eg, valbenazine, deutetrabenazine, cannabinoids), and deep brain stimulation is a promising therapy.

Tics, defined as sudden, rapid, recurrent, nonrhythmic motor movements or vocalizations, are essential components of Tourette syndrome. Although some tics may be mild, others can cause significant psychosocial, physical, and functional difficulties that affect daily activities. In addition to tics, most affected individuals have coexisting neuropsychological difficulties (attention deficit hyperactivity disorder, obsessive-compulsive disorder, anxiety, mood disorder, disruptive behaviors, schizotypal traits, suicidal behavior, personality disorder, antisocial activities, and sleep disorders) that can further impact social and academic activities or employment.
Amplifying Migrant Voices and Struggles at Sea as a Radical Practice
Authors: Schwarz Nina Violetta , Stierl Maurice
Published: July 2019

This article takes the encounters between migrant travelers at sea and Alarm Phone activists on land as a starting point to inquire into recent transformations in maritime migrant mobilities and EUropean and North African attempts to govern them, with a focus on the western Mediterranean Sea. The Alarm Phone, an activist hotline assisting migrants in distress at sea, has been involved in everyday struggles over movement in all three Mediterranean regions, so that tracing its interventions can provide insights into the complex interplay between enactments of the freedom of movement and the ways in which EUrope seeks to preempt and deter them. Situated right at the nexus of migrant movements conceived in a kinetic and a political sense, the Alarm Phone constitutes an analytic of the EUropean border regime, able to observe the interplay between disobedient movements and their policing at sea.
Born in Translation
Authors: Dirlik Arif
Published: July 2019

Around the turn of the twentieth century, late Qing (1644–1911) thinkers settled on an ancient term, Zhongguo, as an appropriate name for the nation-form to supplant the empire that had run its course. The renaming was directly inspired by the “Western” idea of “China,” which had no equivalent in native geopolitical conceptions of the area so designated and “mis-recognized” its historical political configurations. The renaming called for radical re-signification of the idea of Zhongguo, the political and cultural space it presupposed, and the identification it demanded of its constituencies. Crucial to its realization was the reimagination of the past and the present’s relationship to it. This essay explores the reasons late Qing intellectuals felt it necessary to rename the country, the inspiration they drew upon, and the spatial and temporal presuppositions of the new idea of China/Zhongguo. Their reasoning reveals the modern origins of historical claims that nationalist and Orientalist historiography has endowed with timeless longevity.
Dialectics of Sovereignty, Compromise, and Equality in the Discourse on the “Tibetan Question”
Authors: Dhompa Tsering Wangmo
Published: July 2019

Since 1950, the Chinese government has determined the status and position of Tibetans, but it has not won the battle for Tibetans’ hearts and minds. Ongoing Tibetan resistance under Chinese rule points to serious fissures in the Chinese state’s ideological and cultural project of “liberating” Tibet. Wang Hui’s article “The ‘Tibetan Question’ East and West: Orientalism, Regional Ethnic Autonomy, and the Politics of Dignity” analyzes the March 2008 “riots” in and around Lhasa in order to understand the impediments to a real solution to the crisis in Tibet. This piece suggests that although Wang Hui offers productive ways of moving beyond the status quo, his analysis of Tibet is limited by multiple ideological contradictions that ultimately fail to lift Tibet out of the advanced/backward binary that typifies late nineteenth-century orientalism.
Disease modelling in human organoids
Authors: Lancaster Madeline A. , Huch Meritxell
Published: July 2019

The past decade has seen an explosion in the field of in vitro disease modelling, in particular the development of organoids. These self-organizing tissues derived from stem cells provide a unique system to examine mechanisms ranging from organ development to homeostasis and disease. Because organoids develop according to intrinsic developmental programmes, the resultant tissue morphology recapitulates organ architecture with remarkable fidelity. Furthermore, the fact that these tissues can be derived from human progenitors allows for the study of uniquely human processes and disorders. This article and accompanying poster highlight the currently available methods, particularly those aimed at modelling human biology, and provide an overview of their capabilities and limitations. We also speculate on possible future technological advances that have the potential for great strides in both disease modelling and future regenerative strategies.
Two-Sided Matching with (Almost) One-Sided Preferences
Authors: Haeringer Guillaume , Iehlé Vincent
Published: July 2019

In a two-sided matching context we show how we can predict stable matchings by considering only one side’s preferences and the mutually acceptable pairs of agents. Our methodology consists of identifying impossible matches, i.e., pairs of agents that can never be matched together in a stable matching of any problem consistent with the partial data. We analyze data from the French academic job market for mathematicians and show that the match of about 45 percent of positions (and about 60 percent of candidates) does not depend on the preferences of the hired candidates, unobserved and submitted at the final stage of the market. (JEL C78, I23, J41, J44)
Dominance and Competitive Bundling
Authors: Hurkens Sjaak , Jeon Doh-Shin , Menicucci Domenico
Published: July 2019

We study how bundling affects competition between two asymmetric multi-product firms. One firm dominates the other in that it produces better products more efficiently. For low (high) levels of dominance, bundling intensifies (relaxes) price competition and lowers (raises) both firms’ profits. For intermediate dominance levels, bundling increases the dominant firm’s market share substantially, thereby raising its profit while reducing its rival’s profit. Hence, the threat to bundle is then a credible foreclosure strategy. We also identify circumstances in which a firm that dominates only in some markets can profitably leverage its dominance to other markets by tying all its products. (JEL D43, K21, L13, L41)
Treatment planning for proton therapy: what is needed in the next 10 years?
Authors: Nystrom Hakan , Jensen Maria Fuglsang , Nystrom Petra Witt
Published: July 2019

Treatment planning is the process where the prescription of the radiation oncologist is translated into a deliverable treatment. With the complexity of contemporary radiotherapy, treatment planning cannot be performed without a computerized treatment planning system. Proton therapy (PT) enables highly conformal treatment plans with a minimum of dose to tissues outside the target volume, but to obtain the most optimal plan for the treatment, there are a multitude of parameters that need to be addressed. In this review areas of ongoing improvements and research in the field of PT treatment planning are identified and discussed. The main focus is on issues of immediate clinical and practical relevance to the PT community highlighting the needs for the near future but also in a longer perspective. We anticipate that the manual tasks performed by treatment planners in the future will involve a high degree of computational thinking, as many issues can be solved much better by e.g. scripting. More accurate and faster dose calculation algorithms are needed, automation for contouring and planning is required and practical tools to handle the variable biological efficiency in PT is urgently demanded just to mention a few of the expected improvements over the coming 10 years.
Turning the tables: A university league-table based on quality not quantity
Authors: Barnett Adrian G. , Moher David
Published: July 2019

Background: Universities closely watch international league tables because these tables influence governments, donors and students. Achieving a high ranking in a table, or an annual rise in ranking, allows universities to promote their achievements using an externally validated measure. However, league tables predominantly reward measures of research output, such as publications and citations, and may therefore be promoting poor research practices by encouraging the “publish or perish” mentality.

Methods: We examined whether a league table could be created based on good research practice. We rewarded researchers who cited a reporting guideline, which help researchers report their research completely, accurately and transparently, and were created to reduce the waste of poorly described research. We used the EQUATOR guidelines, which means our tables are mostly relevant to health and medical research. We used Scopus to identify the citations.

Results: Our cross-sectional tables for the years 2016 and 2017 included 14,408 papers with 47,876 author affiliations. We ranked universities and included a bootstrap measure of uncertainty. We clustered universities in five similar groups in an effort to avoid over-interpreting small differences in ranks.

Conclusions: We believe there is merit in considering more socially responsible criteria for ranking universities, and this could encourage better research practice internationally if such tables become as valued as the current quantity-focused tables.
An Advising Initiative for Online Students on Academic Probation
Authors: Miller Nathan , Greer Katherine , Cozier Lindsey , Whitener Stephanie , Patton Jerry , Koffarnus Julie
Published: July 2019

Online courses are increasingly popular with students, and postsecondary institutions are increasing the availability of online courses and degrees. Continued improvements in the academic experience, including academic advising, for students attending online degree programs will be expected as more students take these courses. This article provides an example of how institutions can improve academic advising for online students. An advising initiative designed for residential students on academic probation was adapted for use with online students on academic probation. Discussion of the advising approach used with both populations is included. Outcomes included improved academic standing for both student populations.
Periprosthetic joint infection: current concepts and outlook
Authors: Izakovicova Petra , Borens Olivier , Trampuz Andrej
Published: July 2019

Periprosthetic joint infection (PJI) is a serious complication occurring in 1% to 2% of primary arthroplasties, which is associated with high morbidity and need for complex interdisciplinary treatment strategies. The challenge in the management of PJI is the persistence of micro-organisms on the implant surface in the form of biofilm. Understanding this ability, the phases of biofilm formation, antimicrobial susceptibility and the limitations of host local immune response allows an individual choice of the most suitable treatment. By using diagnostic methods for biofilm detection such as sonication, the sensitivity for diagnosing PJI is increasing, especially in chronic infections caused by low-virulence pathogens. The use of biofilm-active antibiotics enables eradication of micro-organisms in the presence of a foreign body. The total duration of antibiotic treatment following revision surgery should not exceed 12 weeks.

Cite this article: EFORT Open Rev 2019;4:482-494. DOI: 10.1302/2058-5241.4.180092
Uncertainty over the Joint Comprehensive Plan of Action: Iran, the European Union and the United States
Authors: Belal Kulsoom
Published: July 2019

One of the most significant developments of the year 2018 was US President Trump's decision to pull out of the Joint Comprehensive Plan of Action (JCPOA) or Iran Nuclear Deal, a multilateral agreement signed between Iran and China, France, Russia, the United Kingdom, and the United States, plus Germany (P5+1). While the US has withdrawn from the deal and the other signatories to the deal are trying to keep Iran in the deal, Iran sees little return in remaining part of the deal. Hence, there is uncertainty about its survival. To study the future of JCPOA, the paper analyzes the future course of action of Iran, the EU and the US vis-à-vis the deal. It looks at US efforts to scuttle the deal, the internal and external pressures on Iran to abide or abandon the deal, and the EU's attempts to appease the US while keeping Iran in the deal. Furthermore, it looks at the bilateral relations between stakeholders and predicts the consequences of the course of action taken by each stakeholder.
Pak-Afghan Water Issue: A Case for Benefit-Sharing
Authors: Malik Tasleem
Published: July 2019

Despite being intertwined by geographical, linguistic, regional, religious and ethnic knots, Pakistan and Afghanistan have experienced upheavals in their bilateral relations. Changing regional and international political interests have further complicated their relations. Besides confronting traditional security challenges, Pakistan and Afghanistan are facing a severe non-traditional security threat, i.e., the issue of shared waters without any regulatory mechanism. Despite efforts of international organizations in the past, both countries have failed to reach an agreement over the shared waters. Currently, they are following a unilateral water strategy. Afghanistan-India joint water projects further complicate the situation as Pakistan is already facing issues with the latter due to the increasing number of Indian projects on western rivers. Though water may be critical for the recovery of Afghanistan's agriculture based economy, the projects on Kabul River may have serious implications on downstream irrigation and initiatives, the ecology and bilateral relations between the two riparian countries, Pakistan and Afghanistan. Linked closely to the conflicts among states and societies, water as an environmental security issue must be dealt with the same urgency as traditional security challenges. This paper analyzes the security perceptions in Pakistan and Afghanistan and contends that the probability of a future conflict over shared water has not been duly attended. There is a need to develop an integrated mechanism based on the fundamental principle of benefit-sharing instead of dividing waters or any unilateral decisions.
BB Integra – Portal de Inteligência Pública: Uma ferramenta no Controle Social da Gestão Municipal / BB Integra – Portal of Public Intelligence: A Tool of Social Control of Municipality Management
Authors: Ferro Kleucia Garleny De Castro Constantino , Albuquerque Emmanuel Ferro , Silva Maria Gabriela Jandiroba
Published: July 2019

O controle da gestão pública pode ser exercido por meio dos representantes eleitos, das entidades de fiscalização e pelo cidadão. O presente estudo tem como objetivo apresentar à comunidade acadêmica e à população em geral, uma alternativa de acompanhamento de controle social digital, de maneira integrada em apenas uma plataforma, simplificando o acesso aos dados públicos, distribuídos em várias bases de dados de diversas fontes públicas. A pesquisa foi realizada de forma bibliográfica e exploratória, inicialmente pela busca de embasamento teórico sobre o controle social e apresentação das funcionalidades da plataforma digital BB Integra – Portal Inteligência Pública, mantida pelo Banco do Brasil. A pesquisa demonstrou que a ferramenta está disponível a qualquer cidadão, sem a necessidade de cadastro e o seu uso é bastante simplificado, apresentando vários dados de 22 instituições públicas de maneira integrada. Sugere-se que outros estudos sejam realizados, pois existe uma escassez de pesquisas desenvolvidas sobre o BB Integra disponíveis na Biblioteca Digital Brasileira de Teses e Dissertações – BDTD entre outras bases de consulta, para que dessa forma outras análises possam expandir o estudo do tema.
A Internet das Coisas e suas implicações na Educação / The Internet of Things and its Implications in Education
Authors: Araújo Marcos Alberto de , Galhardo Cristiane Xavier , Santos Vivianni Marques Leite dos
Published: July 2019

A Internet das Coisas é uma inovação tecnológica que está presente fortemente no dia-a-dia das pessoas e tem encontrado aplicação em diversos setores da sociedade. Este artigo aborda os conceitos de Internet das Coisas e suas implicações para a área da educação. Como metodologia, concentrou-se em uma revisão da literatura na base de dados Periódicos Capes nos últimos 5 anos e em uma busca de anterioridade na base de dados de registros de computador do Instituto Nacional de Propriedade Industrial. O objetivo principal desse estudo foi obter um diagnóstico acerca das iniciativas de Internet das Coisas para melhorias na educação. Como resultado constata-se que a crescente utilização de recursos tecnológicos em sala de aula e a conectividade destes dispositivos com outros objetos potencializam o processo de ensino-aprendizagem e tem encontrado aplicações, principalmente, no que se refere a plataformas educacionais, e também no gerenciamento de informações sobre os estudantes por meio dos acessos feitos em suas plataformas.
Breve histórico da Educação Ambiental no Brasil / Brief History of Environmental Education in Brazil
Authors: Arraes Maria Cleide Gualter Alencar , Videira Márcia Cristina Moraes Cotas
Published: July 2019

A formação dos profissionais da educação tem direcionado suas atenções para o saber pedagógico, em que o professor é preparado para saber como agir nas mais diversas situações do processo ensino-aprendizagem, bem como, para os conhecimentos, que lhe possibilitam o “ensinar” durante suas aulas. Porém, é importante, que haja um destaque maior para o professor como ser humano, que é diferente e, por isso, não vai seguir sempre as mesmas regras e “receitas”. Este estudo discute um breve histórico sobre a Educação ambiental no Brasil. Os resultados demonstraram que é necessário um maior acompanhado das políticas educacionais implantadas, de forma a garantir uma escola de qualidade para todos.
O mercado brasileiro de Energia Elétrica Livre: um estudo de caso na indústria de Shopping Center sob a ótica da gestão eficiente dos recursos financeiros / The Brazilian free electric market: a case study in the Shopping Center industry from the point of view of the efficient management of financial resources
Authors: Costa Crislane Soares , Oliveira Elane Lopes de , Sousa Josiano Cesar de
Published: July 2019

Este artigo apresenta conceitos referentes ao Mercado Livre de Energia Brasileiro, com enfoque nos consumidores especiais e define a estruturação institucional do Setor Elétrico Brasileiro. Para sua elaboração, utilizou-se o método de estudo de caso, através de uma pesquisa exploratória realizada em um condomínio empresarial (shopping Center) que pertenceu ao mercado cativo e realizou a migração para o mercado livre de energia de elétrica. O objetivo desta pesquisa é analisar a viabilidade financeira da migração de um condomínio varejista do mercado cativo para o mercado de energia elétrica livre, sob a ótica da gestão eficiente dos recursos financeiros. Como resultado, o estudo realizado comprovou a viabilidade financeira da adesão ao mercado livre, através da análise do ponto de equilíbrio financeiro, possibilitando previsibilidade orçamentaria e uma melhor gestão dos recursos financeiros e quantificaram a redução de custos com o fornecimento de energia elétrica através da a migração do ambiente de contratação regulada para o ambiente de contratação livre. Ao final, o estudo apresenta suas limitações e as recomendações para o desenvolvimento de futuras pesquisas.
Considerações Sobre Educação Inclusiva / Considerations on Inclusive Education
Authors: Oliveira Gilmar Antônio De , Brito Ana Lúcia Bizerril de , Almeida Angelita Silva de , Ferreira Maria da Conceição Pereira
Published: July 2019

Este artigo discute a educação inclusiva enquanto demanda para promover a igualdade de oportunidades, valorizando as diferenças humanas, sejam elas quais forem: raciais, culturais, intelectuais, sociais, físicas, sensoriais ou de gênero. Para isso aconteça, é preciso que haja uma completa transformação no ensino, das práticas e de suas políticas adotadas, para que se possa assegurar um ensino inclusivo e democrática todos. As discussões levaram a conclusão de que, integração de alunos especiais em escolas regulares tem sido mais valorizada nos últimos anos, e isso parece ser resultado de constantes debates a respeito de educação de indivíduos com alguma deficiência e de um maior engajamento da sociedade, para que sejam respeitados os direitos dessas pessoas.
O Posicionamento do MEI Perante a Crise Econômica: Um Estudo Realizado nos MEIs em Bairro da Cidade de Juazeiro do Norte / The Positioning of the MEI Faced with the Economic Crisis: A Study Held in the MEIs in a neighbor of the City of Juazeiro do Norte
Authors: Silva Arlene Lilian Ribeiro , Araujo Michel Oliveira , Saraiva Piedley Macedo
Published: July 2019

Este artigo versa sobre o posicionamento do MEI perante a crise econômica. Um estudo realizado em MEIs do bairro Novo Juazeiro da cidade de Juazeiro do Norte. O objetivo geral foi identificar a disposição do MEI para sobreviver à crise econômica. A metodologia utilizada foi à bibliográfica, descritiva, exploratória e qualitativa, na qual foram aplicados questionários em uma entrevista estruturada a cinco microempreendedores individuais (MEI) do ramo de prestação de serviços, do segmento alimentício. Durante o estudo foi possível constatar as dificuldades que os microempreendedores enfrentaram em meio ao declínio econômico e como eles conseguiram lidar com este processo. Das cincos pessoas entrevistadas, verificou-se que quatro se mostraram com uma boa disposição diante da crise, através da diferenciação no formato e no sabor de seus produtos e no preço acessível. Enquanto que uma dessas pessoas não buscou melhorias e continuou suas atividades sem inovar o seu negócio. Espera-se ao fim deste artigo contribuir de forma significativa para o sucesso empresarial dos MEIs em meio as adversidades da economia.
A mudança linguística na perspectiva funcionalista / A linguistics change in the functionalist perspective
Authors: Souza Adílio Junior de
Published: July 2019

O presente trabalho é uma resenha de “Mudança linguística: uma abordagem baseada no uso”, obra escrita por Mário Eduardo Martelotta, um dos mais renomados linguistas do Brasil. A obra é uma introdução ao estudo da mudança linguistica em uma perspectiva funcionalista e discute acerca dos fenômenos de gramaticalização e lexicalização como temas centrais.
A Influência da Cultura Organizacional nos processos de Recrutamento, Seleção e Treinamento de Recursos Humanos / The Influence of Organizational Culture in Recruitment, Selection and Training of Human Resources
Authors: Saraiva Francisco Diógenes Da Cunha , Escudero Jaime Caiceo
Published: July 2019

A Cultura Organizacional influencia diretamente sobre o comportamento das pessoas que formam uma empresa ou organização, um dos momentos críticos desta relação é a implementação dos processos de recrutamento, seleção e treinamento de pessoas. Esta pesquisa aplicada está inserida na área de administração de recursos humanos. Tem como objetivo descrever como a cultura organizacional influência os processos de recrutamento, seleção e treinamento de pessoas. A empresa objeto da pesquisa é classificada como médio porte e tem como objetivo social o ensino fundamental e médio. Para cumprimento do objetivo utilizou-se do método qualitativo, a partir de estudo de caso. Foi constatado que os principais traços culturais da instituição encontram seu fundamento na proposta educativa criada por Dom Bosco, o chamado Sistema Preventivo de Dom Bosco. Foi identificado certa dissonância entre a fala dos grupos entrevistados quanto a importância do valor da cultura organizacional nos processos de recrutamento, seleção e treinamento, fato que revela que estes procedimentos podem ser otimizados, levando a maior assertividade na contratação e na posterior qualidade dos serviços prestados.
O Counseling como instrumento de aproximação e reconhecimento das experiências emocionais / Counseling as an approach tool and recognition of emotional experiences
Authors: Lima Júnior Carlos Mendes de , Chitolina Adalto Luiz
Published: July 2019

O counseling é quem se dispões a aconselhar. Aquele que reúne um conjunto de habilidades, atitudes e técnicas para ajudar as pessoas a ajudar-se. Parte-se do pressuposto de que o homem já tem em si os recursos necessários, portanto o processo de interação entre o counselor (aconselhador) e o cliente, propõe-se a criar as condições para fazê-los emergir por meio de um colóquio centrado na pessoa. Uma relação ativa e altamente pessoal, antes de ser sobre o problema a ser solucionado. O objetivo do presente estudo foi evidenciar a importância da experiência interna e particular na vida das pessoas, definindo como possibilidade numa relação de ajuda, através da figura do Counseling. Conclusão: Ajudar as pessoas a estarem cônscias de suas limitações e de suas possibilidades, certamente  a ajudarão a perceberem a vida e a si mesmas de uma maneira mais apropriada. Esta condição, implica em uma  melhoria na capacidade de mobilizar recursos internos para reagir mais positivamente às circunstâncias desafiadoras e, consequentemente, a melhorarem sua qualidade de vida emocional.
Avaliação do Risco de Lesão por Pressão em Unidade de Terapia Intensiva / Risk Assessment of Injury Pressure in Intensive Care Unit
Authors: Roxa Vanessa Dayana Souza , Ramos Natana De Morais , Domingos João Emanuel Pereira , Pinheiro José Alexandre Albino , Viana Maria Corina Amaral , Bezerra Adriana De Moraes
Published: July 2019

Objetivo: Avaliar o risco de desenvolvimento de Lesão por Pressão utilizando a escala de Braden em pessoas sob cuidados críticos em uma Unidade de Terapia de Intensiva. Métodos: Estudo realizado em um hospital de médio porte no interior do estado do Ceará, de setembro a novembro de 2016. Aplicou-se um instrumento validado para obtenção de dados clínicos e sociodemográficos associados à escala de Braden. Resultados: Participaram 30 pacientes internados na UTI. Os resultados sociodemográficos mostraram semelhança entre os sexos masculino e feminino; média de idade de 70,3 anos (desvio-padrão:19,3), brancos (73,33%); com escolaridade (40%); responsável legal, filhos (40%), renda familiar entre um e dois salários mínimos (83,33%). 30% da amostra apresentaram alto risco de desenvolver lesão por pressão e 26,66% risco altíssimo. Conclusão: É de extrema relevância a aplicação da Escala de Braden em pacientes críticos pela equipe de Enfermagem, visto que uma lesão pode aumentar os índices de complicação no quadro clínico e elevar a mortalidade e tempo de internação.
Efficacy and Safety of Eluxadoline in Patients With Irritable Bowel Syndrome With Diarrhea Who Report Inadequate Symptom Control With Loperamide: RELIEF Phase 4 Study
Authors: Brenner Darren M. , Sayuk Gregory S. , Gutman Catherine R. , Jo Esther , Elmes Steven J. R. , Liu Louis W. C. , Cash Brooks D.
Published: July 2019

OBJECTIVES:

Irritable bowel syndrome with diarrhea (IBS-D) is a functional gastrointestinal disorder with limited effective treatment options. We evaluated the efficacy and safety of eluxadoline in patients with IBS-D who reported inadequate symptom control with prior loperamide.

METHODS:

Three hundred forty-six adults with IBS-D (Rome III criteria) were randomly assigned to placebo or eluxadoline 100 mg twice daily for 12 weeks. Patients recorded daily IBS-D symptoms, including worst abdominal pain (WAP) and stool consistency (through Bristol Stool Scale). The primary endpoint was proportion of composite responders, defined as patients who met daily composite response criteria (≥40% WAP improvement and <5 Bristol Stool Scale score) for at least 50% of treatment days, and recorded ≥60 days of diary entries over the 12-week period.

RESULTS:

Over 12 weeks, a significantly greater proportion of eluxadoline patients achieved the primary composite responder endpoint compared to placebo (22.7% vs 10.3%, P = 0.002), and component endpoints of improvements in stool consistency (27.9% vs 16.7%, P = 0.01) and WAP (43.6% vs 31.0%, P = 0.02). Additionally, a greater proportion of eluxadoline patients met the composite responder endpoint assessed at monthly intervals compared to placebo (weeks 1–4: 14.0% vs 6.9%, P = 0.03; weeks 5–8: 26.7% vs 14.9%, P = 0.006; weeks 9–12: 30.8% vs 16.7%, P = 0.002). Rates of adverse events were comparable in both groups (37.4% vs 35.3%); no treatment-related serious adverse event, cases of sphincter of Oddi spasm, or pancreatitis were reported.

DISCUSSION:

Eluxadoline appears safe and effective for treating IBS-D symptoms in patients with an intact gallbladder reporting inadequate relief with prior loperamide use.
Hepatic Sinusoidal Obstruction Syndrome in a Patient With Multiple Myeloma Treated With CyBorD
Authors: Tariq Tooba , Dawdy John , Goyal Sachin , Mohamad Bashar , Singh Manmeet , Mutchnick Milton , Ehrinpreis Murray
Published: July 2019

Hepatic sinusoidal obstruction syndrome (SOS) is a life-threatening state generally occurring as a complication of conditioning regimens used for hematopoietic stem cell transplant. Hepatic SOS after a standard dose of chemotherapy in malignancies is rare, and there are only a few cases in pediatric literature. We report a 56-year-old man with multiple myeloma who experienced SOS after being initiated on chemotherapy including cyclophosphamide, dexamethasone, and bortezomib and who experienced a delay in treatment with defibrotide, because it is currently approved by the Food and Drug Administration for only patients who develop SOS after hematopoietic stem cell transplant.
MODEL PEMBELAJARAN TEMATIK PENDIDIKAN AGAMA ISLAM DI SEKOLAH DASAR
Authors: Salamah Umu
Published: July 2019

Thematic approach to teaching and learning especially for Islamic Religious Education in elementary school. This is a way of teaching and learning, whereby many areas of the curriculum are connected together and integrated within a theme. It allows learning to be more natural and less fragmented than the way, where a school day is time divided into different subject areas and whereby children practice exercises frequently related to nothing other than what the teacher thinks up. It guides connected ideas to follow on easily.The model of thematic learning in primary schools can be said to be using the model to share (shared/participative model). This modelis the integration of learning due to the emergence of a fallen-overlapping (overlapping concept) or an idea in two or more subjects.
PENDIDIKAN KARAKTER MELALUI KEGIATAN MENDONGENG DI TK ABA KARANGDUWUR DAN TK MASYITHOH PETANAHAN KABUPATEN KEBUMEN
Authors: Fitriyyah Diamah
Published: July 2019

This study was aimed to describe (1) character values of fairy tales, (2) the presentation of tales by the teacher, and (3) character values that affect daily life of the students. This was a naturalistic qualitative study. Data collection was done through observation, interviews, and documents. The results of this study show the following. (1) Character education that appears in fairy tales is religious values, honesty, discipline, hard working, creative, independence, curiosity, taking pleasure in reading, responsibility, tolerance, democracy, love of peace, communicativeness, awareness of environment and society. (2) The presentation of the fairy tale is by reading the fairy tales from a book, directly telling stories without props, and telling stories with props. The style of telling story with the sounds of figures, inserting chant in fairy tale, and ending by Al Quran, Hadis, or Arab proverb. (3) Character values that affect in dialy life of student are religious values, honest, discipline, hard working, independence, curiosity, responsibility, love of peace, communicativeness, awareness of environment and society.