bluuebunny/crossref_metadata_2025 huggingface dataset:
Tensor products for Gelfand–Shilov and Pilipović distribution spaces
Authors: Toft Joachim
Published: October 2019

We show basic properties on tensor products for Gelfand–Shilov distributions and Pilipović distributions. This also includes the Fubini’s property of such tensor products. We also apply the Fubini property to deduce some properties for short-time Fourier transforms of Gelfand–Shilov and Pilipović distributions.
ON TORUS ACTIONS OF HIGHER COMPLEXITY
Authors: HAUSEN JÜRGEN , HISCHE CHRISTOFF , WROBEL MILENA
Published: October 2019

We systematically produce algebraic varieties with torus action by constructing them as suitably embedded subvarieties of toric varieties. The resulting varieties admit an explicit treatment in terms of toric geometry and graded ring theory. Our approach extends existing constructions of rational varieties with torus action of complexity one and delivers all Mori dream spaces with torus action. We exhibit the example class of ‘general arrangement varieties’ and obtain classification results in the case of complexity two and Picard number at most two, extending former work in complexity one.
Respiratory viruses on personal protective equipment and bodies of healthcare workers
Authors: Phan Linh T. , Sweeney Dagmar , Maita Dayana , Moritz Donna C. , Bleasdale Susan C. , Jones Rachael M. ,   for the CDC Prevention Epicenters Program
Published: October 2019

Objective:

To characterize the magnitude of virus contamination on personal protective equipment (PPE), skin, and clothing of healthcare workers (HCWs) who cared for patients having acute viral infections.

Design:

Prospective observational study.

Setting:

Acute-care academic hospital.

Participants:

A total of 59 HCWs agreed to have their PPE, clothing, and/or skin swabbed for virus measurement.

Methods:

The PPE worn by HCW participants, including glove, face mask, gown, and personal stethoscope, were swabbed with Copan swabs. After PPE doffing, bodies and clothing of HCWs were sampled with Copan swabs: hand, face, and scrubs. Preamplification and quantitative polymerase chain reaction (qPCR) methods were used to quantify viral RNA copies in the swab samples.

Results:

Overall, 31% of glove samples, 21% of gown samples, and 12% of face mask samples were positive for virus. Among the body and clothing sites, 21% of bare hand samples, 11% of scrub samples, and 7% of face samples were positive for virus. Virus concentrations on PPE were not statistically significantly different than concentrations on skin and clothing under PPE. Virus concentrations on the personal stethoscopes and on the gowns were positively correlated with the number of torso contacts (P < .05). Virus concentrations on face masks were positively correlated with the number of face mask contacts and patient contacts (P < .05).

Conclusions:

Healthcare workers are routinely contaminated with respiratory viruses after patient care, indicating the need to ensure that HCWs complete hand hygiene and use other PPE to prevent dissemination of virus to other areas of the hospital. Modifying self-contact behaviors may decrease the presence of virus on HCWs.
Meditation-induced psychosis: a narrative review and individual patient data analysis
Authors: Sharma Pawan , Mahapatra Ananya , Gupta Rishab
Published: October 2019

Background:

Meditation is associated with health benefits; however, there are reports that it may trigger or exacerbate psychotic states. In this review, we aim to collate case reports of psychotic disorders occurring in association with meditative practice and to discuss the relationship between psychosis and meditation.

Methodology:

We performed case-based analysis of all the existing studies published in English language using PubMed, PsycINFO, Cochrane, Scopus, EMBASE, CINAHL and Google Scholar with the search terms; ‘Psychosis’ OR ‘Psychotic Symptoms’ OR ‘Schizophrenia’ AND ‘Meditation.’

Results:

A total of 19 studies and 28 cases were included in the review. The patients described had an age range of 18–57 years; there was equal distribution of males and females. The diagnoses included acute psychosis in 14 cases, schizophrenia in 7 cases, mania with psychotic symptoms in 3 cases, and schizoaffective disorder in 1 case. The types of meditation described were Transcendent, Mindfulness, Buddhist Meditation like Qigong, Zen, and Theraveda, and others like Bikram yoga, Pranic Healing, and Hindustan Type meditation. Of the 28 cases reported, 14 patients had certain precipitating factors like insomnia, lack of food intake, history of mental illness, stress, and psychoactive substance use.

Conclusion:

There are case reports of psychotic disorder arising in association with meditative practice; however, it is difficult to attribute a causal relationship between the two. At the same time, there is a body of research describing the beneficial effect of meditative practice in clinical settings for patients with psychotic disorders. Appropriately designed studies are needed to further investigate the relationship between meditative practice and psychosis.
Governing ethnic unrest: Political Islam and the Kurdish conflict in Turkey
Authors: Günay Onur , Yörük Erdem
Published: October 2019

How can we explain the mass appeal and electoral success of Islamist political parties? What are the underlying sources of the Islamist political advantage? Scholars have provided numerous answers to these widely debated questions, variously emphasizing the religious nature of the discourses in Islamist movements, their ideological hegemony, organizational capacity, provision of social services, reputation, and structural factors. However, one key aspect of Islamist movements has been underexplored in the current literature; namely, Islamists’ promises to resolve ethnic questions that remain unresolved in secularist nation-states. In this article, we argue that the extent to which Islamists govern ethnic unrest significantly shapes their electoral success and ability to establish broader hegemony. Based on ethnographic and sociological data, this article explores one particular recent electoral puzzle that reveals the limits of the scholarly literature on Islamist political advantage, examining the ethnic politics of the governing Justice and Development Party (Adalet ve Kalkınma Partisi, AKP) in Turkey.
Clinical landmarks in chronic otitis media with tympanosclerosis: clinical history may have predictive value in the diagnosis of ossicular chain mobility
Authors: Dinç A E , Kumbul Y Ç
Published: October 2019

Objectives

To evaluate clinical characteristics of tympanosclerosis and to investigate the predictive value of clinical evaluation in diagnosing the ossicular chain status in tympanosclerosis.

Methods

The study included 166 ears operated on for chronic otitis media. Age, gender, duration of symptoms and history of ear drainage were recorded from the patient's file. Details of ossicular mobility were obtained from the operation records.

Results

There was no difference in age or disease duration between ears with chronic otitis media with or without tympanosclerosis. The ears with chronic otitis media without tympanosclerosis had a higher rate of middle-ear suppuration compared to those with tympanosclerosis (p< 0.001). In chronic otitis media with tympanosclerosis, the ears with a mobile ossicular chain had a higher rate of active drainage in their clinical history compared to ears with a fixed ossicular chain (p= 0.026). Stapes fixation was present mostly in dry ears with tympanosclerosis (p= 0.005).

Conclusion

Chronic otitis media with tympanosclerosis is characterised by the long-term absence of suppurations. The probability of having a fixed ossicular chain or stapes was higher in tympanosclerosis cases with no ear drainage.
Developing evidence-based behavioural strategies to overcome physiological resistance to weight loss in the general population
Authors: Stubbs R. James , Duarte Cristiana , O'Driscoll Ruairi , Turicchi Jake , Michalowska Joanna
Published: October 2019

Physiological and behavioural systems are tolerant of excess energy intake and responsive to energy deficits. Weight loss (WL) changes body structure, physiological function and energy balance (EB) behaviours, which resist further WL and promote subsequent weight regain. Measuring and understanding the response of EB systems to energy deficits is important for developing evidence-based behaviour change interventions for longer-term weight management. Currently, behaviour change approaches for longer-term WL show modest effect sizes. Self-regulation of EB behaviours (e.g. goal setting, action plans, self-monitoring, relapse prevention plans) and aspects of motivation are important for WL maintenance. Stress management, emotion regulation and food hedonics may also be important for relapse prevention, but the evidence is less concrete. Although much is known about the effects of WL on physiological and psychological function, little is known about the way these dynamic changes affect human EB behaviours. Key areas of future importance include (i) improved methods for detailed tracking of energy expenditure, balance and by subtraction intake, using digital technologies, (ii) how WL impacts body structure, function and subsequent EB behaviours, (iii) how behaviour change approaches can overcome physiological resistance to WL and (iv) who is likely to maintain WL or relapse. Modelling physiological and psychological moderators and mediators of EB-related behaviours is central to understanding and improving longer-term weight and health outcomes in the general population.
The secular problem of evil: an essay in analytic existentialism
Authors: PRESCOTT PAUL
Published: October 2019

The existence of evil is often held to pose philosophical problems only for theists. I argue that the existence of evil gives rise to a philosophical problem which confronts theist and atheist alike. The problem is constituted by the following claims: (1) Successful human beings (i.e. those meeting their basic prudential interests) are committed to a good-enough world; (2) the actual world is not a good-enough world (i.e. sufficient evil exists). It follows that human beings must either (3a) maintain a state of epistemic ignorance regarding the nature of the actual world or (3b) abandon their basic prudential interests. Theists resolve this problem by rejecting (2), only to confront the problem of evil as it is traditionally understood. Successful atheists also reject (2), but without adequate grounds for doing so.
“Place-ing” Dementia Prevention and Care in NunatuKavut, Labrador
Authors: Pace Jessica
Published: October 2019

Le vieillissement de la population autochtone du Canada a mis en évidence l’importance du milieu de vie et de la culture sur la santé et la résilience dans le parcours de vie. La présente étude expose les résultats d’un projet Photovoix portant sur les expériences des Inuits du Sud lors de transitions associées au troisième âge et à la démence au NunatuKavut (Labrador). Dans cette région, la culture et l’environnement naturel occupent une place prépondérante dans les descriptions des activités de promotion de la santé et des trajectoires de soins. Ces facteurs peuvent contribuer au vieillissement en santé, offrir une protection contre le déclin cognitif et favoriser le maintien de l’identité des personnes atteintes de démence. Or, les modes de vie ancrés dans la terre ancestrale font l’objet de fortes pressions. Ces pressions affectent les perspectives des aînés Inuits du Sud de vieillir et d’être soignés « dans leur milieu ». Les résultats de cette recherche reflètent la nécessité d’élaborer des approches de soutien pour les aînés Inuits du Sud désirant vieillir dans leur milieu, en considérant les conceptions culturelles de la personne et les politiques et programmes qui promeuvent l’engagement envers la nature et la culture.
The social withdrawal and social anxiety feedback loop and the role of peer victimization and acceptance in the pathways
Authors: Barzeva Stefania A. , Richards Jennifer S. , Meeus Wim H. J. , Oldehinkel Albertine J.
Published: October 2019

Social withdrawal and social anxiety are believed to have a bidirectional influence on one another, but it is unknown if their relationship is bidirectional, especially within person, and if peer experiences influence this relationship. We investigated temporal sequencing and the strength of effects between social withdrawal and social anxiety, and the roles of peer victimization and acceptance in the pathways. Participants were 2,772 adolescents from the population-based and clinically referred cohorts of the Tracking Adolescents' Individual Lives Survey. Self- and parent-reported withdrawal, and self-reported social anxiety, peer victimization, and perceived peer acceptance were assessed at 11, 13, and 16 years. Random-intercept cross-lagged panel models were used to investigate within-person associations between these variables. There was no feedback loop between withdrawal and social anxiety. Social withdrawal did not predict social anxiety at any age. Social anxiety at 11 years predicted increased self-reported withdrawal at 13 years. Negative peer experiences predicted increased self- and parent-reported withdrawal at 13 years and increased parent-reported withdrawal at 16 years. In turn, self-reported withdrawal at 13 years predicted negative peer experiences at 16 years. In conclusion, adolescents became more withdrawn when they became more socially anxious or experienced greater peer problems, and increasing withdrawal predicted greater victimization and lower acceptance.
Geographic range and conservation of the Cipo CanasteroAsthenes luizae, an endemic furnariid of Brazilian sky islands
Authors: FREITAS GUILHERME H. S. , COSTA LÍLIAN M. , CHAVES ANDERSON V. , VASCONCELOS MARCELO F. , RIBEIRO LEONARDO C. , SILVA JULIANO C. , SOUZA RONEY A. , SANTOS FABRÍCIO R. , RODRIGUES MARCOS
Published: October 2019

Cipo CanasteroAsthenes luizaeis a relict ovenbird restricted to rocky outcrops at high elevations within thecampo rupestrevegetation of the Espinhaço Range in the state of Minas Gerais, south-eastern Brazil. This poorly known species is considered ‘Near Threatened’, but recent studies have suggested that it should be listed under a higher category of threat. To contribute to the knowledge of this species and its conservation assessment and related planning, we compiled all literature records of the species distribution (n= 16 locations), collected new data on its occurrence (n= 72 locations), and calculated its geographic range using four different approaches. First, we defined the sky islands where the species occurs (nine units) using the lowest elevation value recorded (1,100 m asl) as a cut-off. Second, we performed species distribution modelling (SDM) across the sky islands and identified an area of 2,225.21 km2. Third, we measured the species’ extent of occurrence (EOO = 24,555.85 km2) and used SDM to estimate its upper limit (EOOup = 30,697.58 km2). Fourth, we measured the area of occupancy (AOO = 228 km2) and used SDM to estimate its upper limit (AOOup = 1,827.39 km2). We analysed the Cipo Canastero sky islands in terms of landscape metrics including size, isolation, protected area coverage, shape index, core area index, and proportion covered by SDM. We observed a very fragmented distribution, especially in the North sector of the species distribution, composed of small and isolated populations (separated by up to 112 km); the South sector is the core of its distribution and is composed of larger, more connected patches with differences in shape complexity that are not strongly influenced by an edge effect. The range sizes calculated, along with other reported information regarding population and habitat trends, justifies the inclusion of the species in at least the ‘Vulnerable’ category.
Nurturing and Balancing the World: A Relational Approach to Rock Art and Technology from North Central Chile (Southern Andes)
Authors: Troncoso Andrés , Armstrong Felipe , Vergara Francisco , Ivanovic Francisca , Urzúa Paula
Published: October 2019

Technology has been a central theme in archaeological discussion. Different approaches have been developed in order to understand and better explain the processes that lead to the production of objects and things. The anthropology of technology has been one such effort, with its focus on technological style and thechaîne opératoire. In this paper we argue that, despite their many contributions, these approaches tend to isolate the process of production, as well as to see it as the imposition of culture over nature. Instead, we propose a relational approach to technology, one that considers the multiple participants in the social actions involved, stressing the affective qualities of the different entities participating in the process of making. We focus this discussion on the production process of rock art in North Central Chile by Diaguita communities (c.ad1000–c. 1540), arguing that making petroglyphs was a central activity that aimed at the balancing of the world and its participants, creating a mediating space that facilitated connectedness between the multiple members of the Diaguita world, humans and other-than-humans.
New Perspectives on Twentieth-Century Catholicism
Authors: Forlenza Rosario
Published: October 2019

Until the 1980s the history of the Roman Catholic Church and Catholicism in modern Europe was mostly the preserve of the theologically and confessionally defined field of ‘church history’ or ‘ecclesiastic history’. Catholic historiography was sealed off from mainstream (North American and British) historiography, with nineteenth- and twentieth-century Catholicism seemingly little more than a backward-looking footnote in the dominant narrative of secular modernity and progress. In a 1991 review article David Blackbourn pointed out that ‘historians in the mainstream have commonly considered Catholicism, if they considered it at all, as a hopelessly obscurantist force at odds with the more serious isms that have shaped the modern age’. Within the same review, however, Blackbourn signaled the emergence of timid but nevertheless clear ‘signs of a change’ in the historiographical direction and a new interest in Catholic history.
Goodbye to Grand Politics: The Cane Sugar Campaign and the Limits of Transnational Activism, 1968–1974
Authors: van Dam Peter
Published: October 2019

In 1968 Dutch activists launched a campaign focused on cane sugar as a symbol of unfair trading conditions for the global South. The history of the cane sugar campaign from 1968 to 1974 highlights how European integration provided hope for large-scale change and a common target. This led activists to establish European networks and campaigns. Its demise sheds new light on the new social movements’ shift from ‘grand politics’, aimed at a sudden and drastic transformation through global and European politics, towards incremental change by locally targeting specific companies and countries.
Consuming Anti-Consumerism: The German Fairtrade Movement and the Ambivalent Legacy of ‘1968’
Authors: Möckel Benjamin
Published: October 2019

The article explores the influence of ‘1968’ on the West German fair trade movement. It argues that 1968 constituted an ambivalent legacy for the perception of mass consumerism: while the 1960s student movement radically criticised modern consumer society, it also put new emphasis on consumer products as markers of individual identity. The article analyses this relationship by focusing on the design, representation and advertising of fair trade products by the German fair trade organation GEPA. The first two case studies examine the politicisation of fair trade products in its early campaigns in the 1970s and the subsequent attempts to use everyday products like coffee, tea and honey to educate consumers about their individual lifestyles. The third case study looks at the GEPA's first mail-order catalogues and asks how the GEPA tried to transform an icon of modern mass consumerism into a tool to communicate its fair trade approach.
In congenitally corrected transposition of great arteries following Fontan surgery, a left ventricle with suprasystemic systolic and high end-diastolic pressures paradoxically preserves right ventricular and tricuspid valve function
Authors: Wadile Santosh , Sheriff Ejaz A. , Sivakumar Kothandam
Published: October 2019

Systemic right ventricular function in congenitally corrected transposition depends on septal geometry. Suprasystemic left ventricular systolic pressures and high end-diastolic pressures after Fontan surgery paradoxically preserve right ventricular function.
Language selection contributes to intrusion errors in speaking: Evidence from picture naming
Authors: Zheng Xiaochen , Roelofs Ardi , Lemhöfer Kristin
Published: October 2019

Bilinguals usually select the right language to speak for the particular context they are in, but sometimes the nontarget language intrudes. Despite a large body of research into language selection and language control, it remains unclear where intrusion errors originate from. These errors may be due to incorrect selection of the nontarget language at the conceptual level, or be a consequence of erroneous word selection (despite correct language selection) at the lexical level. We examined the former possibility in two language switching experiments using a manipulation that supposedly affects language selection on the conceptual level, namely whether the conversational language context was associated with the target language (congruent) or with the alternative language (incongruent) on a trial. Both experiments showed that language intrusion errors occurred more often in incongruent than in congruent contexts, providing converging evidence that language selection during concept preparation is one driving force behind language intrusion.
Are similar control processes implemented during single and dual language production? Evidence from switching between speech registers and languages
Authors: Declerck Mathieu , Ivanova Iva , Grainger Jonathan , Duñabeitia Jon Andoni
Published: October 2019

To investigate whether similar control processes are used during single and dual language production, we compared register switching (formal and informal speech in the same language) vs. language switching (French and English). The results across two experiments showed a positive correlation of overall register- and language-switch costs and similar formal French switch costs across the two switching tasks. However, whereas increasing the cue-to-stimulus interval resulted in a reduction of language-switch costs, register-switch costs were unaffected by the interval manipulation. This difference in switch-cost pattern indicates that control processes are not entirely identical during single and dual language production.
Advancement of taxonomic searches in the European search catalogue for plant genetic resources
Authors: Kreide Stefanie , Oppermann Markus , Weise Stephan
Published: October 2019

Genebanks play an important role in the conservation of global plant biodiversity. The European Search Catalogue for Plant Genetic Resources (EURISCO) was created as a central entry point to provide information on these collections. However, a major challenge lies in the heterogeneity of scientific plant names. This makes the selection of suitable plant material, e.g. for research or breeding purposes, significantly more difficult. For this reason, the taxonomic backbone of EURISCO has been completely revised. Search terms entered by users are now automatically checked against taxonomic reference repositories, allowing a variety of synonyms to be identified. In addition, a fuzzy search has been implemented, which makes the search function tolerant of erroneous data (e.g. caused by typing errors). Besides improvements of the search interface, more support will be given to EURISCO's data providers. The new developments provide a tool that makes it easier to identify problem cases within the data, such as accepted/non-accepted taxonomic names, and will successively improve the quality of taxonomic information in EURISCO.
Physicians' attitudes towards accelerated access to medicines
Authors: Pace Jessica , Kerridge Ian , Pearson Sallie , Lipworth Wendy
Published: October 2019

In recent years, a variety of ‘accelerated access’ schemes have been introduced by pharmaceutical regulators and funders globally. These schemes aim to overcome perceived regulatory and reimbursement barriers to accessing medicines – particularly for patients with limited time or therapeutic options. However, patient access to approved medicines is mediated by a number of third parties including regulators and payers, and physicians who act both as gatekeepers and guides to prescribed medications. It is therefore essential to know how physicians think about accelerated access as they are responsible for advising patients on and prescribing medicines made available via these pathways. We conducted semi-structured interviews with 18 Australian physicians focusing on their attitudes towards accelerated access. We identified three ‘archetypes’ of physicians: ‘confident accelerators’, ‘cautious accelerators’, and ‘decelerators’. Although all acknowledged the potential risks and benefits of accelerated access, they disagreed on their magnitude and extent and how they should be balanced in both policy formation and clinical practice. Overall, our results illustrate the diversity of clinical opinions in this area and the importance of monitoring both the prescribing and clinical outcomes that result from accelerated access programmes to ensure that these are both clinically and morally acceptable.
Big Data Enters Environmental Law
Authors: Lajaunie Claire , Schafer Burkhard , Mazzega Pierre
Published: October 2019

Big Data is now permeating environmental law and affecting its evolution. Data-driven innovation is highlighted as a means for major organizations to address social and global challenges. We present various contributions of Big Data technologies and show how they transform our knowledge and understanding of domains regulated by environmental law – environmental changes, socio-ecological systems, sustainable development issues – and of environmental law itself as a complex system. In particular, the mining of massive data sets makes it possible to undertake concrete actions dedicated to the elaboration, production, implementation, follow-up, and adaptation of the environmental targets defined at various levels of decision making (from the international to the subnational level).

This development calls into question the traditional approach to legal epistemology and ethics, as implementation and enforcement of rules take on new forms, such as regulation through smart environmental targets and securing legal compliance through the design of technological artefacts. The entry of Big Data therefore requires the development of a new and specific epistemology of environmental law.
High‐Speed Solar Wind Streams in 2007–2008: Turning on the Russell‐McPherron Effect
Authors: Munteanu C. , Hamada A. , Mursula K.
Published: October 2019

Two sequences of five high‐speed solar wind stream/corotating interaction region (HSS/CIR) events were observed at 1 AU in December 2007–2008. These two HSS/CIR sequences had opposite magnetic polarities, and they originated from two persistent low‐latitude coronal holes with corresponding polarities. Each HSS/CIR event triggered a geomagnetic storm and strong high‐latitude activity. We follow the evolution of the properties and geomagnetic effects of the two sequences and find that the sequence with negative interplanetary magnetic field polarity (toward sector) develops systematically a more negative Bz(GSM) component and becomes relatively more geoeffective when moving from winter solstice in 2007 to spring equinox in 2008. On the other hand, the sequence with positive polarity (away sector) develops systematically a less negative Bz(GSM) component and becomes relatively less geoeffective. These changes allow the first detailed monitoring of the turning on of the Russell‐McPherron effect when moving from solstice to equinox and the development of the related changes in high‐latitude geomagnetic activity and geomagnetic storms.
Reply to Comment by Jennings et al. on “Investigating Earth's Formation History Through Copper and Sulfur Metal‐Silicate Partitioning During Core‐Mantle Differentiation”
Authors: Mahan B. , Siebert J. , Badro J. , Borensztajn S. , Moynier F.
Published: October 2019

Recognizing existing materials that can act as proxies for Earth's building blocks, and understanding the accretionary pathway taken during Earth's growth, persist as outstanding issues in need of resolution. In Mahan, Siebert, Blanchard, Badro, et al. (2018, https://doi.org/10.1029/2018JB015991), we conducted diamond anvil cell (DAC) Cu metal‐silicate partitioning experiments and coupled these results with a large complement of literature data to characterize Cu metal‐silicate partitioning during Earth's core formation and accretion history. The Comment of Jennings, Wade, and Llovet (2019, https://doi.org/10.1029/2018JB016930) contends that secondary X‐ray fluorescence, originating from the Cu holders that experiments are routinely welded to (“lift‐out” grids), compromises the novel Cu partitioning data of Mahan, Siebert, Blanchard, Badro, et al. (2018) beyond utility. To dispel these concerns and further validate our data, we have (i) investigated secondary X‐ray fluorescence effects in a Cu‐free experiment and provided a matrix‐matched data correction, and (ii) rewelded a DAC experiment from a Cu grid to a Mo grid for a comparison of compositional analyses and Cu partitioning results. Secondary fluorescence results, in fact much like the simulated results in Jennings, Wade, and Llovet (2019), indicate that this effect is essentially equal in the metal and silicate phases and therefore has no actual impact on Cu metal‐silicate partition coefficients. Moreover, Cu concentrations and partition coefficients determined using the Mo grid are statistically indistinguishable from that determined using the Cu grid. All results decisively illustrate that while secondary X‐ray fluorescence must be considered where absolute concentrations are the final objective, it has had no meaningful impact on the partitioning data and observations of Mahan, Siebert, Blanchard, Badro, et al. (2018).
Systematic Detection of Clustered Seismicity Beneath the Southwestern Alps
Authors: Beaucé Eric , Frank William B. , Paul Anne , Campillo Michel , van der Hilst Robert D.
Published: October 2019

We present a new automated earthquake detection and location method based on beamforming (or back projection) and template matching and apply it to study the seismicity of the Southwestern Alps. We use beamforming with prior knowledge of the 3‐D variations of seismic velocities as a first detection run to search for earthquakes that are used as templates in a subsequent matched‐filter search. Template matching allows us to detect low signal‐to‐noise ratio events and thus to obtain a high spatiotemporal resolution of the seismicity in the Southwestern Alps. We describe how we address the problem of false positives in energy‐based earthquake detection with supervised machine learning and how to best leverage template matching to iteratively refine the templates and the detection. We detected 18,754 earthquakes over 1 year (our catalog is available online) and observed temporal clustering of the earthquake occurrence in several regions. This statistical study of the collective behavior of earthquakes provides insights into the mechanisms of earthquake occurrence. Based on our observations, we infer the mechanisms responsible for the seismic activity in three regions of interest: the Ubaye valley, the Briançonnais, and the Dora Maira massif. Our conclusions point to the importance of fault interactions to explain the earthquake occurrence in the Briançonnais and the Dora Maira massif, whereas fluids seem to be the major driving mechanism in the Ubaye valley.
Inverse Magnetic Susceptibility Fabrics in Pelagic Sediment: Implications for Magnetofossil Abundance and Alignment
Authors: Usui Yoichi , Yamazaki Toshitsugu , Oka Toshitaka , Kumagai Yuho
Published: October 2019

Single‐domain magnetite particles exhibit minimum susceptibility along their elongation, resulting in so‐called inverse fabric of the anisotropy of magnetic susceptibility (AMS). We report the discovery of inverse AMS fabrics from pelagic clay recovered by a ∼12 m long piston core from the western North Pacific. A previous study identified fossil single‐domain magnetite produced by magnetotactic bacteria (magnetofossils) as the dominant ferrimagnetic mineral in the sediment. The inverse AMS fabrics were found in a ∼2 m zone. The ∼6 and ∼4 m of sediment above and below this zone showed normal, horizontal AMS fabrics. Rock magnetic data and ferromagnetic resonance spectroscopy indicated that magnetofossils account for most of the mean susceptibility regardless of normal or inverse AMS. This was explained by the mixing models where the inverse fabric from magnetofossils is nearly balanced by the normal fabrics of terrigenous minerals. The corrected degree of AMS carried by magnetofossils in the sediment was estimated to be ∼1.01, which is comparable to that of typical pelagic sediment at shallow depth. On the other hand, terrigenous minerals in the sediment were estimated to have higher degree of anisotropy, possibly reflecting burial and subsequent erosion of >80 m of sediment, which was also suggested by a subbottom acoustic stratigraphy. This suggests that inverse AMS fabrics due to magnetofossils may be widespread in pelagic clay without strong compaction.
The Nearshore Heat Budget: Effects of Stratification and Surfzone Dynamics
Authors: Sinnett Gregory , Feddersen Falk
Published: October 2019

Temperature variability in the nearshore (from ≈6‐m depth to the shoreline) is influenced by many processes including wave breaking and internal waves. A nearshore heat budget resolving these processes has not been considered. A 7‐month experiment at the Scripps Institution of Oceanography Pier (shoreline to 6‐m depth) measured temperature and surface and cross‐shore heat fluxes to examine a nearshore heat budget with fine cross‐shore spatial (≈20 m) and temporal (5 day to 4 h) resolution. Winds, waves, air and water temperature, and in particular, pier end stratification varied considerably from late Fall to late Spring. The largest heat flux terms were shortwave solar radiation and baroclinic advective heat flux both varying on tidal time scales. The net heat flux is coherent and in phase with the nearshore heat content change at diurnal and semidiurnal frequencies. The binned mean heat budget has squared correlation R2=0.97 and best‐fit slope of 0.76. Including an elevated breaking wave albedo parameterization reduced the residual heat flux and improved the best‐fit slope. Baroclinic and barotropic advective heat fluxes have significant noise, and removing them from the heat budget improves the best‐fit slope when stratification is weak. However, when daily mean stratification is large, baroclinic advective heat flux dominates variability and is required to capture large (≈3 °C h−1) internal wave events. At times, large heat budget residuals highlight neglected heat budget terms, pointing to surfzone alongshore advection of temperature anomalies.
Structure and Performance of GFDL's CM4.0 Climate Model
Authors: Held I. M. , Guo H. , Adcroft A. , Dunne J. P. , Horowitz L. W. , Krasting J. , Shevliakova E. , Winton M. , Zhao M. , Bushuk M. , Wittenberg A. T. , Wyman B. , Xiang B. , Zhang R. , Anderson W. , Balaji V. , Donner L. , Dunne K. , Durachta J. , Gauthier P. P. G. , Ginoux P. , Golaz J.‐C. , Griffies S. M. , Hallberg R. , Harris L. , Harrison M. , Hurlin W. , John J. , Lin P. , Lin S.‐J. , Malyshev S. , Menzel R. , Milly P. C. D. , Ming Y. , Naik V. , Paynter D. , Paulot F. , Ramaswamy V. , Reichl B. , Robinson T. , Rosati A. , Seman C. , Silvers L. G. , Underwood S. , Zadeh N.
Published: October 2019

We describe the Geophysical Fluid Dynamics Laboratory's CM4.0 physical climate model, with emphasis on those aspects that may be of particular importance to users of this model and its simulations. The model is built with the AM4.0/LM4.0 atmosphere/land model and OM4.0 ocean model. Topics include the rationale for key choices made in the model formulation, the stability as well as drift of the preindustrial control simulation, and comparison of key aspects of the historical simulations with observations from recent decades. Notable achievements include the relatively small biases in seasonal spatial patterns of top‐of‐atmosphere fluxes, surface temperature, and precipitation; reduced double Intertropical Convergence Zone bias; dramatically improved representation of ocean boundary currents; a high‐quality simulation of climatological Arctic sea ice extent and its recent decline; and excellent simulation of the El Niño‐Southern Oscillation spectrum and structure. Areas of concern include inadequate deep convection in the Nordic Seas; an inaccurate Antarctic sea ice simulation; precipitation and wind composites still affected by the equatorial cold tongue bias; muted variability in the Atlantic Meridional Overturning Circulation; strong 100 year quasiperiodicity in Southern Ocean ventilation; and a lack of historical warming before 1990 and too rapid warming thereafter due to high climate sensitivity and strong aerosol forcing, in contrast to the observational record. Overall, CM4.0 scores very well in its fidelity against observations compared to the Coupled Model Intercomparison Project Phase 5 generation in terms of both mean state and modes of variability and should prove a valuable new addition for analysis across a broad array of applications.
Circulating biomarkers in patients with glioblastoma
Authors: Müller Bark Juliana , Kulasinghe Arutha , Chua Benjamin , Day Bryan W. , Punyadeera Chamindie
Published: October 2019

Gliomas are the most common tumours of the central nervous system and the most aggressive form is glioblastoma (GBM). Despite advances in treatment, patient survival remains low. GBM diagnosis typically relies on imaging techniques and postoperative pathological diagnosis; however, both procedures have their inherent limitations. Imaging modalities cannot differentiate tumour progression from treatment-related changes that mimic progression, known as pseudoprogression, which might lead to misinterpretation of therapy response and delay clinical interventions. In addition to imaging limitations, tissue biopsies are invasive and most of the time cannot be performed over the course of treatment to evaluate ‘real-time’ tumour dynamics. In an attempt to address these limitations, liquid biopsies have been proposed in the field. Blood sampling is a minimally invasive procedure for a patient to endure and could provide tumoural information to guide therapy. Tumours shed tumoural content, such as circulating tumour cells, cell-free nucleic acids, proteins and extracellular vesicles, into the circulation, and these biomarkers are reported to cross the blood–brain barrier. The use of liquid biopsies is emerging in the field of GBM. In this review, we aim to summarise the current literature on circulating biomarkers, namely circulating tumour cells, circulating tumour DNA and extracellular vesicles as potential non-invasively sampled biomarkers to manage the treatment of patients with GBM.
Salt-inducible kinase 1 regulates bone anabolism via the CRTC1–CREB–Id1 axis
Authors: Kim Min Kyung , Kwon Jun-Oh , Song Min-Kyoung , Kim Bongjun , Kim Haemin , Lee Zang Hee , Koo Seung-Hoi , Kim Hong-Hee
Published: October 2019

New bone anabolic agents for the effective treatment of bone metabolic diseases like osteoporosis are of high clinical demand. In the present study, we reveal the function of salt-inducible kinase 1 (SIK1) in regulating osteoblast differentiation. Gene knockdown of SIK1 but not of SIK2 or SIK3 expression in primary preosteoblasts increased osteoblast differentiation and bone matrix mineralization. SIK1 also regulated the proliferation of osteoblastic precursor cells in osteogenesis. This negative control of osteoblasts required the catalytic activity of SIK1. SIK1 phosphorylated CREB regulated transcription coactivator 1 (CRTC1), preventing CRTC1 from enhancing CREB transcriptional activity for the expression of osteogenic genes like Id1. Furthermore, SIK1 knockout (KO) mice had higher bone mass, osteoblast number, and bone formation rate versus littermate wild-type (WT) mice. Preosteoblasts from SIK1 KO mice showed more osteoblastogenic potential than did WT cells, whereas osteoclast generation among KO and WT precursors was indifferent. In addition, bone morphogenic protein 2 (BMP2) suppressed both SIK1 expression as well as SIK1 activity by protein kinase A (PKA)–dependent mechanisms to stimulate osteogenesis. Taken together, our results indicate that SIK1 is a key negative regulator of preosteoblast proliferation and osteoblast differentiation and that the repression of SIK1 is crucial for BMP2 signaling for osteogenesis. Therefore, we propose SIK1 to be a useful therapeutic target for the development of bone anabolic strategies.
The interplay between regeneration and scavenging fluxes drives ocean iron cycling
Authors: Tagliabue Alessandro , Bowie Andrew R. , DeVries Timothy , Ellwood Michael J. , Landing William M. , Milne Angela , Ohnemus Daniel C. , Twining Benjamin S. , Boyd Philip W.
Published: October 2019

Despite recent advances in observational data coverage, quantitative constraints on how different physical and biogeochemical processes shape dissolved iron distributions remain elusive, lowering confidence in future projections for iron-limited regions. Here we show that dissolved iron is cycled rapidly in Pacific mode and intermediate water and accumulates at a rate controlled by the strongly opposing fluxes of regeneration and scavenging. Combining new data sets within a watermass framework shows that the multidecadal dissolved iron accumulation is much lower than expected from a meta-analysis of iron regeneration fluxes. This mismatch can only be reconciled by invoking significant rates of iron removal  to balance iron regeneration, which imply generation of authigenic particulate iron pools. Consequently, rapid internal cycling of iron, rather than its physical transport, is the main control on observed iron stocks within intermediate waters globally and upper ocean iron limitation will be strongly sensitive to subtle changes to the internal cycling balance.
Two-dimensional electronic spectroscopy reveals liquid-like lineshape dynamics in CsPbI3 perovskite nanocrystals
Authors: Seiler Hélène , Palato Samuel , Sonnichsen Colin , Baker Harry , Socie Etienne , Strandell Dallas P. , Kambhampati Patanjali
Published: October 2019

Lead-halide perovskites have attracted tremendous attention, initially for their performance in thin film photovoltaics, and more recently for a variety of remarkable optical properties. Defect tolerance through polaron formation within the ionic lattice is a key aspect of these materials. Polaron formation arises from the dynamical coupling of atomic fluctuations to electronic states. Measuring the properties of these fluctuations is therefore essential in light of potential optoelectronic applications. Here we apply two-dimensional electronic spectroscopy (2DES) to probe the timescale and amplitude of the electronic gap correlations in CsPbI3 perovskite nanocrystals via homogeneous lineshape dynamics. The 2DES data reveal irreversible, diffusive dynamics that are qualitatively inconsistent with the coherent dynamics in covalent solids such as CdSe quantum dots. In contrast, these dynamics are consistent with liquid-like structural dynamics on the 100 femtosecond timescale. These dynamics are assigned to the optical signature of polaron formation, the conceptual solid-state analogue of solvation.
Structural water and disordered structure promote aqueous sodium-ion energy storage in sodium-birnessite
Authors: Shan Xiaoqiang , Guo Fenghua , Charles Daniel S. , Lebens-Higgins Zachary , Abdel Razek Sara , Wu Jinpeng , Xu Wenqian , Yang Wanli , Page Katharine L. , Neuefeind Joerg C. , Feygenson Mikhail , Piper Louis F. J. , Teng Xiaowei
Published: October 2019

Birnessite is a low-cost and environmentally friendly layered material for aqueous electrochemical energy storage; however, its storage capacity is poor due to its narrow potential window in aqueous electrolyte and low redox activity. Herein we report a sodium rich disordered birnessite (Na0.27MnO2) for aqueous sodium-ion electrochemical storage with a much-enhanced capacity and cycling life (83 mAh g−1 after 5000 cycles in full-cell). Neutron total scattering and in situ X-ray diffraction measurements show that both structural water and the Na-rich disordered structure contribute to the improved electrochemical performance of current cathode material. Particularly, the co-deintercalation of the hydrated water and sodium-ion during the high potential charging process results in the shrinkage of interlayer distance and thus stabilizes the layered structure. Our results provide a genuine insight into how structural disordering and structural water improve sodium-ion storage in a layered electrode and open up an exciting direction for improving aqueous batteries.
Lithiophilic montmorillonite serves as lithium ion reservoir to facilitate uniform lithium deposition
Authors: Chen Wei , Hu Yin , Lv Weiqiang , Lei Tianyu , Wang Xianfu , Li Zhenghan , Zhang Miao , Huang Jianwen , Du Xinchuan , Yan Yichao , He Weidong , Liu Chen , Liao Min , Zhang Wanli , Xiong Jie , Yan Chenglin
Published: October 2019

The growing demand for lithium batteries with higher energy densities requires new electrode chemistries. Lithium metal is a promising candidate as the anode material due to its high theoretical specific capacity, negative electrochemical potential and favorable density. However, during cycling, low and uneven lithium ion concentration on the surface of anode usually results in uncontrolled dendrite growth, especially at high current densities. Here we tackle this issue by using lithiophilic montmorillonite as an additive in the ether-based electrolyte to regulate the lithium ion concentration on the anode surface and thus facilitate the uniform lithium deposition. The lithiophilic montmorillonite demonstrates a pumping feature that improves the self-concentrating kinetics of the lithium ion and thus accelerates the lithium ion transfer at the deposition/electrolyte interface. The signal intensity of TFSI− shows negligible changes via in situ Raman tracking of the ion flux at the electrochemical interface, indicating homogeneous ion distribution, which can lead to a stable and uniform lithium deposition on the anode surface. Our study indicates that the interfacial engineering induced by the lithiophilic montmorillonite could be a promising strategy to optimize the lithium deposition for next-generation lithium metal batteries.
Multiomics analysis of tolerant interaction of potato with potato virus Y
Authors: Stare Tjaša , Ramšak Živa , Križnik Maja , Gruden Kristina
Published: October 2019

Potato virus Y (PVY) is the most economically important viral pathogen of potato worldwide. Different potato cultivars react to the pathogen differently, resulting in resistant, tolerant or disease outcome of the interaction. Here we focus on tolerant interaction between potato cv. Désirée and PVYNTN. To capture the response in its full complexity, we analyzed the dynamic changes on multiple molecular levels, including transcriptomics, sRNAomics, degradomics, proteomics and hormonomics. The analysis was complemented by the measurements of viral accumulation, photosynthetic activity and phenotypisation of the symptoms. Besides cv. Désirée we also studied its transgenic counterpart depleted for the accumulation of salicylic acid (NahG-Désirée). This multiomics analysis provides better insights into the mechanisms leading to tolerant response of potato to viral infection and can be used as a base in further studies of plant immunity regulation.