bluuebunny/crossref_metadata_2025 huggingface dataset:
EFFECTS OF ZIZIPHORA CLINOPODIOIDES EXTRACT ON POLYCYSTIC OVARY SYNDROME, OBESITY, AND INSULIN RESISTANCE
Authors: Nabiuni Prof. Mohammad
Published: January 2025

Background: Polycystic ovary syndrome (PCOS) is the most common hormonal disorder in women of reproductive age. The anti-inflammatory properties of the Ziziphora clinopodioides plant inhibit the NF-KB signal by suppressing the oxidative stress pathway in cells and preventing inflammation. Therefore, the present study aimed to investigate the effects of Z. clinopodioides extract on PCOS, obesity, and insulin resistance.
Methods: In this experimental study, 60 adult Wistar rats were divided into three control (n=12), PCOS (n12), and experimental groups(n=12). After inducing the syndrome for 60 days, the experimental groups were injected intraperitoneally with 100, 150, and 200 mg/kg body weight for 10 successive days. The animals were euthanized with chloroform and their ovaries and blood were collected for histomorphometric and hormonal studies and to determine the inflammatory index CRP levels. Data were analyzed using the one-way ANOVA at a significance level of p < 0.05.
Results: Changes in the weight of animals were observed in the control and PCOS groups (n = 12 per group). The body weight of the PCOS group rats increased significantly (P < 0.001) compared to the control group. A significant increase was recorded in the ovarian weight of the PCOS group compared to the control group (n = 12 per group). Comparison of ovarian weights in the PCOS group and the PCOS group treated with Z. clinopodioides extract (n = 12 per group) indicated a significant decrease in the PCOS group treated with Z. clinopodioides extract for 10 consecutive days compared to the PCOS group.
Conclusion: The anti-inflammatory effects of Z. clinopodioides extract can significantly reduce ovarian weight in the PCOS group.
คาร์บอนดอตสำหรับการยับยั้งเชื้อแบคทีเรียด้วยกลไกการบำบัดด้วยแสง
Authors: เดชศรี กรณัฐ , จิตโรภาส ผดุงขวัญ , อัครมงคลพร ประเสริฐ , เพ็งนาม สุภัสสร , โอปณะโสภิต ปราณีต
Published: January 2025

โรคติดเชื้อเป็นปัญหาสำคัญต่อระบบสาธารณสุขของประเทศไทยและทั่วโลก โดยเฉพาะอย่างยิ่งปัญหาการดื้อยาปฏิชีวนะสำหรับการยับยั้งเชื้อแบคทีเรีย ปัจจุบันมีการนำอนุภาคนาโนเข้ามาประยุกต์ใช้สำหรับการยับยั้งเชื้อแบคทีเรีย รวมทั้งสามารถเพิ่มฤทธิ์ผ่านการกระตุ้นด้วยแสง เนื่องจากเป็นอนุภาคที่ไม่ทําให้เซลล์หรือเนื้อเยื่อปกติได้รับความเสียหาย มีความเป็นพิษต่ำ อีกทั้งยังไม่ก่อให้เกิดการดื้อยาหรือช่วยลดผลข้างเคียงจากการรักษาด้วยยาปฏิชีวนะแบบดั้งเดิม บทความนี้กล่าวถึง คาร์บอนดอต ซึ่งเป็นหนึ่งในอนุภาคระดับนาโนหรือนาโนพาร์ทิเคิลที่สามารถนำมาประยุกต์ใช้ในการยับยั้งเชื้อแบคทีเรีย และมีข้อดีเหนือกว่านาโนพาร์ทิเคิลชนิดอื่น คือ มีสมบัติเชิงแสงที่โดดเด่น สามารถเรืองแสงฟลูออเรสเซนต์และสามารถดูดกลืนแสงในช่วงอัลตราไวโอเลตและช่วงวิสิเบิลได้ ซึ่งเป็นสมบัติสำคัญสำหรับการบำบัดด้วยแสง อีกทั้งยังสามารถเข้ากับเซลล์สิ่งมีชีวิตได้ดี มีความเป็นพิษต่ำ กระจายตัวได้ดีในน้ำ สังเคราะห์ง่าย รวดเร็ว มีเสถียรภาพสูง และสามารถเติมหมู่ฟังก์ชันบนพื้นผิวได้ บทความนี้ได้รวบรวมข้อมูลทั่วไป วิธีการสังเคราะห์ กลไกการยับยั้งเชื้อแบคทีเรีย และหลักการเพิ่มประสิทธิภาพการยับยั้งเชื้อแบคทีเรียเมื่อกระตุ้นด้วยแสงของคาร์บอนดอต
Valoración de Activos biológicos en el sector ganadero vacuno Provincia de Cotopaxi, cantón Latacunga y Salcedo
Authors: Minta Caiza Estefanía Geoconda , Cofre Carasayo Doris Magali , Espín Balseca Lorena del Rocío
Published: January 2025

Las normas internacionales de contabilidad (NIC), en específico la NIC 41, relacionada con el sector agrícola permite un apropiado control, registro y valoración de activos biológicos, que es importante para los tomadores de decisión, este artículo tienen el  propósito diagnosticar la valoración de activos biológicos, así como el registro de sus  costos en el proceso de crianza del ganado vacuno según NIC 41 en las Asociaciones ganaderas vacuno que pertenecientes  a la provincia de Cotopaxi, cantón Latacunga y salcedo, la metodología aplicada es cualitativa que se realizó la aplicación de un cuestionario a los  6 socios de las asociaciones ganaderas vacuno, se detectaron dificultades a la hora de valorar los activos biológicos, en este caso del ganado vacuno, pues no se cumple lo establecido por la NIC 41en algunas asociaciones. Para valorar su producción inicial y final, la mayoría de las empresas ya utilizan el criterio de valor razonable por encima del costo histórico, lo que les facilita la toma de decisiones oportunas y pertinentes los registros contables que se deben aplicar según la naturaleza de las operaciones se presentan entre los resultados.
PENGARUH PENDIDIKAN KARAKTER TERHADAP BERPIKIR KRITIS SISWA DI ERA MASA KINI
Authors: Desty Endrawati Subroto  , Ratih Cahniyati Putri  , Windi Novianti  , Selviyana Putri  , Nafalie Cheisya Dermawan
Published: January 2025

This research aims to analyze the relationship between character education and the Z generation’s critical thinking skills in order to become intelligent and characterful individuals to compete globally. This research uses literature analysis methods. The results show that character education involves three main aspects, namely understanding good values, loving good values, and applying good values. Character education is an important element in forming individuals with integrity and noble character. In the digital era, the influence of social media, wide access to information and technology emphasizes the need for more relevant character education. This research examines the role of character education, the challenges faced, and strategies for overcoming them through a holistic approach involving families and society with wise use of technology.
ESPOROTRICOSE FELINA: ABORDAGEM TERAPÊUTICA COM ANFOTERICINA B
Authors: Donatilio Mariana Silvestre de Oliveira , Boabaid Wanessa Ferreira , Barbosa Isadora Aparecida Reis , Xavier Carlos Henrique da Silva , Palma Maurício Luiz Mesquita de , Ferreira Juliana Silva
Published: January 2025

Sporotrichosis, common in felines, is caused by the fungus Sporothrix spp, transmitted mainly by bites and scratches. The standard treatment is itraconazole, but in refractory cases, injectable Amphotericin B is used in combination to enhance efficacy by altering the cell membrane of the fungus. The research had the general objective of describing the therapeutic approach with Amphotericin B. In addition, its methodology consists of a literature review, covering research within the last five years. It was concluded that Amphotericin B is effective in refractory cases, but great caution should be exercised in its use, as it intensely affects the animal's renal system.
TIC NA PRÁTICA DOCENTE: DESAFIOS E POSSIBILIDADES NO ENSINO FUNDAMENTAL.
Authors: Rodrigues Rafaelly Maysa Balbino , Carvalho João Paulo Rodrigues de
Published: January 2025

O presente artigo tem o objetivo de constatar e analisar os desafios e as possibilidades das Tecnologias da informação e comunicação (TICs) na prática pedagógica. A pesquisa foi elaborada através de duas vertentes: Revisão bibliográfica e estudo de caso, este último foi elaborado um questionário com 14 perguntas aplicado a 10 professores dos anos iniciais e finais do ensino fundamental na escola municipal Diá Azevedo localizado no município de Bom Jesus, Rio Grande do Norte. As questões foram elaboradas de forma mista, incluindo perguntas abertas e fechadas, buscando captar percepções e experiências dos docentes. Os resultados revelaram que os principais desafios enfrentados estão relacionados a falta de infra estrutura e a falta de formações específicas que preparam os professores para integrar as TICs em suas práticas pedagógicas. Apesar dos desafios os entrevistados reconhecem a importância do uso das tecnologias de informação e comunicação para o enriquecimento do ensino, principalmente na promoção de metodologias mais dinâmicas e atrativas para os alunos. Infere-se destacar que embora existam barreiras significativas, o uso apropriado das TICs pode transformar positivamente o ensino público, desde que sejam feitas melhorias na infraestrutura e oferecidas capacitações contínuas aos educadores.
ANALISIS PENERAPAN AKUNTANSI BERTERIMA UMUM PADA SEKOLAH DASAR ISLAM TERPADU HARAPAN BUNDA BANDAR
Authors: Sugiarto  , Wazna Fikria  , Intan Imam Sutanto
Published: January 2025

Penelitian ini bertujuan untuk menganalisis kesesuaian penerapan akuntansi di SDIT Harapan Bunda Bandar dengan prinsip-prinsip Akuntansi Berterima Umum. Data yang diperoleh dikelompokkan berdasarkan topik pembahasan untuk kemudian dianalisis. Penulis menggunakan metode deskriptif dalam analisis data, yaitu dengan menelaah dan menguraikan data yang didapat, lalu membandingkannya dengan berbagai referensi. Jenis data yang dikumpulkan meliputi data primer dan data sekunder. Data primer diperoleh melalui wawancara dengan staf sekolah, mencakup informasi seperti laporan yang kemudian diolah dan disusun kembali. Sementara itu, data sekunder berupa data yang telah tersedia, mencakup sejarah sekolah, struktur organisasi, laporan keuangan (laporan posisi keuangan, laba rugi, buku harian, dan daftar aset). Hasil penelitian menunjukkan bahwa penerapan akuntansi di SDITHarapan Bunda Bandar belum sepenuhnya sesuai dengan prinsip Akuntansi Berterima Umum.
Formation of wood obstructions at bridges: processes, related problems, and prediction tools
Authors: Innocenti Lorenzo , Coscarella Francesco , Persi Elisabetta , Comiti Francesco , Francalanci Simona , Larese Antonia , Macchione Francesco , Panici Diego , Petaccia Gabriella , Sibilla Stefano , Solari Luca , Termini Donatella
Published: January 2025

The primary cause of many bridge collapses is related to hydraulic issues, and the Italian technical standards for constructions (NTC 2018) offer limited guidance on the design and verification criteria for bridges, especially concerning river processes. Recognizing this gap, a working group dedicated to “Hydraulic Compatibility of Bridges” (sites.google.com/view/gii-ponti) was established in 2021. The group's objective is to develop proposals for good practices and guidelines that assess bridge hydraulic compatibility, providing a foundation for both bridge safety and flood risk analysis. Within this initiative, a working subgroup focused on floating debris is striving to define a methodology for assessing the impacts of wood accumulation on bridges. While wood in rivers is environmentally beneficial, its transport and accumulation at bridges during high-stage events can lead to problematic consequences. Over the past two decades, the scientific community has actively studied wood transport dynamics, accumulation formation at bridges, and their effects on hydraulics and structural stability. Although some methodologies to assess wood-related risk have been incorporated into national legislation or practitioner reports, these implementations vary widely in defining the shape of accumulation, the wood volume assessment and the number of parameters considered. In many cases, qualitative evaluations are used for estimation due to the complexity and high site specificity inherent in wood transport dynamics. This work aims to propose a comprehensive approach, based on the latest research findings, (i) to define the wood accumulation probability at a bridge, (ii) to estimate the size and position of the accumulation, and (iii) to suggest a methodology for the estimation of bridge scour induced by wood accumulation.
Leveraging Artificial Intelligence to unlock Next-Generation SHM software: Advanced Feature Extraction and Damage Identification
Authors: Garcia-Macias Enrique , Tomassini Elisa , Hernández-González Israel Alejandro , Filippo Ubertini
Published: January 2025

The significant socio-economic impacts of aging infrastructure have driven the growing implementation of Structural Health Monitoring (SHM) worldwide as a key preventive maintenance strategy. However, scaling SHM systems nationwide presents significant hardware and software challenges, particularly in managing densely instrumented structures and deploying effective damage identification algorithms. This explains the circumstance that most SHM software tools are custom-built by specialized research groups, limiting technology transfer. In this context, although still in its early stages, the latest advances in Artificial Intelligence (AI) offer promising solutions to overcome these scalability issues. In this line, this work introduces the latest developments of MOVA/MOSS, a comprehensive SHM software platform developed by the authors that leverages AI to accelerate feature extraction in vibration-based systems and generate digital twins for quasi real-time damage identification. The potential of the developed platform is demonstrated through a real-world structure, the Mendez Nuñez Bridge in Spain, highlighting AI’s potential in facilitating the widespread adoption of SHM.
, Harmony at Harmonia? – Glamor and farce in Hello, Dolly!, from Wilder to Kelly
Authors: Vatain-Corfdir Julie
Published: January 2025

This article explores the stage-to-screen reinventions of style, comedy and spectacular effects in Hello, Dolly!, taking into account three diverging versions of the same narrative: Thornton Wilder’s play The Matchmaker (1954), the Broadway show Hello, Dolly! created by Jerry Herman, Michael Stuart and Gower Champion (1964), and its Hollywood adaptation directed by Gene Kelly (1969). As may be expected, the transfer to the musical stage implies shifts in scale and structure, translating physical comedy into choreography; but the screen transposition further introduces alterations in tone, sentimentality and narrative intention which create a greater distance with Wilder’s original farce. Hesitating between a spirit of preservation, a logic of amplification and a “Hollywoodized” romantic intent, Kelly’s film creates an impression of imbalance – without, however, diminishing the value of Barbra Streisand’s vocal and verbal contribution to the role of Dolly.
Les coulisses du musical , de Candide à My Fair Lady : entretien avec Julien Neyer (interview par Anne Martina)
Authors: Martina Anne , Neyer Julien
Published: January 2025

Chanteur lyrique de formation classique, Julien Neyer se produit depuis quinze ans sur diverses scènes nationales, principalement en tant que choriste, et il a notamment chanté dans quatre comédies musicales produites par le Théâtre du Châtelet (Candide, On The Town, My Fair Lady, Sunday in the Park with George). Il évoque ici avec Anne Martina cette expérience de comédie musicale américaine en France – le travail des répétitions, l’importance du chorégraphe et du metteur en scène, la complicité des équipes, l’impact du micro… – nous dévoilant ainsi les coulisses du musical.
Narrative realism and the musical: sutures of space, time, and perspective
Authors: Blim Dan
Published: January 2025

Although musicals are seldom deemed “realistic,” they frequently rely on realistic narrative elements that produce continuity of time, space, and perspective for audiences. At certain moments, however, that continuity is challenged. A musical may feature multiple stories simultaneously, may disrupt the linear chronology of the story, or may portray the fantasy or subjective perspective of one of its characters. Such moments require what I term “sutures” – a method to ensure clarity and continuity to the staging or filming. A comparison of how stage and screen media suture these moments differently illuminates the unique abilities and limitations of each medium, and thereby helps scholars and audience to analyze directorial choices in adaptation.
Proposed Improvements to Production Facility Layout Using ARC and ARD at Home Industry Aurora Official
Authors: Shiddiqi Muhammad Hasbi Ash , Ismiyah Elly , Negoro Yanuar Pandu
Published: January 2025

Home Industry Aurora Official, which is engaged in the manufacture of pillows and baby mattresses, faces problems related to inefficient facility layouts in the workflow. Suboptimal layouts result in excessive waste of distance, which affects production time and reduces operational efficiency. This study aims to design a more efficient facility layout by minimizing the distance between production processes. The methods used in this study are the ARC (Activity Relationship Chart) and ARD (Activity Relationship Diagram) methods, which can help design layouts based on the relationships between production activities and determine the relationships between activities based on their priority level of proximity. Based on the analysis results, the initial layout produces a total distance of 940 meters, while the two alternative proposed layouts produce distances of 310 meters and 405 meters respectively. Of the two proposed layouts, proposed layout 1 was chosen as the proposed layout for the company with a total distance of 310 meters, with a decrease of 67% from 100% of the total distance of the initial layout. The results of this study indicate that the application of proposed layout 1 can improve workflow efficiency and reduce waste time in the production process.
CARTOGRAFIA DA GAMIFICAÇÃO NO ENSINO DE POTENCIAÇÃO
Authors: Santos Moisés da Silva , Souza Djane da Silva , Alves Deive Barbosa
Published: January 2025

Esta pesquisa, realizada na Escola Estadual Professora Silvandira Sousa Lima do município de Araguaína - TO, teve como objetivo investigar o impacto da utilização de jogos digitais, produzido no software Scratch sobre potenciação para alunos de uma turma do 7º ano. Através de um mapeamento procedente do método cartográfico, foi possível identificar que a utilização do Scratch promoveu um aumento significativo na participação dos alunos durante as aulas, além de contribuir para uma melhor compreensão dos conceitos matemáticos envolvidos. Este trabalho descreve o percurso de uma pesquisa qualitativa de caráter exploratório que se alinha ao método cartográfico, conforme proposto por Passos, Kastrup e Escóssia (2015), essa perspectiva sublinha a natureza interventiva da cartografia, que se propõe a mapear acontecimentos reais, o que sugere uma postura ativa do pesquisador em relação ao fenômeno estudado. Os resultados apontam que a gamificação proporcionada pelo Scratch torna o ensino de matemática mais atrativo e engajador, contribuindo para uma mudança na percepção dos alunos em relação à disciplina.
PATINTERO
Authors: Dula Valentine O.
Published: January 2025

No abstract.
Fiber-Reinforced Thermoelectric Tile As An Alternative Source Of Energy
Authors:   Technological Institute of the Philippines, Facunla Rowel
Published: January 2025

Urban heating in modern cities that raises the temperature by 1℃ to 3℃ than the ordinary environment temperature due to the presence of high thermal mass materials present within the environment is a phenomenon called the Urban Heat Island Effect. These materials tend to store huge amount of thermal energy resulting to more humid environment temperature. This study proposes a method of reducing urban heating by converting thermal heat energy to electrical energy using fiber-reinforced thermoelectric tiles. The design of these tiles makes use of the concept of flywheel effect. Materials that possess high thermal mass can store thermal energy when the ambient temperature is higher than the material and releases it back when the ambient temperature is cooler. The study aims to convert the stored heat energy in materials to usable energy instead of being released back to the environment. This is accomplished by employing concrete cement mixed with carbon and aluminum fibers that act as n-type and p-type material, respectively, arranged in a way that one side is exposed to high temperature and the other side to low temperature. Result showed that a temperature difference between 15℃ and 35℃ can induce voltage and current between 0.75V to 1.80 V and 1.15A to 1.28 A, respectively, for a 305 cm × 305 cm tile. Moreover, result showed that while converting the absorbed heat energy, the ambient temperature cools down faster compared to using typical concrete tiles.
Effect Of Nitrogen From Different Sources On The Growth And Biomass Production Of Spirulina Platensis (Gomont) Geitler
Authors:   Research Institute for Science and Technology, Office of the Vice-President for Research, Extension, Planning and Development, Polytechnic University of the Philippines Department of Biology, College of Science, Polytechnic University of the Philippines, Manila, Philippines, Coronado Armin , Cabbarubias Florabelle , Arocha Leineleen Jerah Mae ,   Department of Biology, College of Science, Polytechnic University of the Philippines, Manila, Philippines
Published: January 2025

Spirulina platensis is a filamentous cyanobacterium known for its promising nutritional value used in several industries. The biomass produced after 24-days cultivation treated with sodium nitrate is significantly higher (0.001 <α0.05) than the cultures treated with urea. Cultures given with nitrogen concentration of 1.648 g/L of sodium nitrate had the highest optical density (5.895 ± 1.095) and dried biomass (2.265 ± 0.390 mg/mL) but not significantly higher with other sodium nitrate treatments (OD: 0.395 > α0.05, DBM: 0.629 >α0.05). The findings suggest that urea is not recommended as an alternative nitrogen source for Spirulina. Results also showed that lower nitrogen concentrations (0.103 g/L) of sodium nitrate can be used to cultivate Spirulina without compromising the biomass production. Moreover, this study showed that the peak of growth rate happens during the 16th day of cultivation.
China – US. relations: Strategic competition in the manufacturing of semiconductors and the status of Taiwan
Authors: Irfan Usama
Published: January 2025

Of all the active conflicts and disputes in the world, the most dangerous are those with the potential to trigger a wider regional or global conflict. In order to understand where these conflicts may originate and how they might be set off, we must analyze these potential “fault lines” in order to identify the dangers and act accordingly. In this paper, through a qualitative and quantitative analysis of the factors impacting the disputed territory, we will attend to understand the Taiwan issue, the factors which may cause or prevent an armed conflict, and how we can expect it to evolve in the future. This is a dispute which has the potential to bring two superpowers into direct armed conflict with one another and trigger a global economic crisis. As a result, it may be in the best interest of all sides involved to prefer the diplomatic approach.
Hybrid nitrile-based reactive diluent for phthalonitrile resins
Authors: Terekhov Vladimir E. , Morozov Oleg S. , Babkin Alexander V. , Kepman Alexey V. , Avdeev Viktor Vasilyvich , Bulgakov Boris A.
Published: January 2025

A hybrid diluent containing both phthalonitrile and benzonitrile functions was tested for improvement of phthalonitrile resin processability. The composites were obtained by the solvent-free prepreg technique and characterized by thermal and mechanical tests (σ11+ = 640 MPa at room temperature with 100
Synthesis, study of biological activity, and hemocompatibility of potential antitumor compounds of thiazolopyrimidinium systems
Authors: Shemchuk Olga S. , Paponov Boris V. , Rakitianskii Danil A. , Kalyuzhny Dmitrii N. , Rumyantsev Andrey M. , Sambuk Elena V. , Bublik Iliya М. , Khomenko Polina V. , Andoskin Pavel A. , Molchanov Oleg E. , Maistrenko Dmitry Nikolaevich , Semenov Konstantin Nikolaevich , Sharoyko Vladimir Vladimirovich
Published: January 2025

Four novel antitumor agents, representatives of (E)-5-(4- dimethylaminostyryl)-7-methylthiazolo[3,2-a]pyrimidin-4-ium salts, were synthesized by sequential reactions of the corresponding aminothiazoles with acetylacetone and 4-dimethylaminobenzaldehyde. Cytotoxicity was assessed on five different cell lines (HeLa, PANC-1, A549, MCF-7, and ECV304). The results indicate that the salts have significant potential for further development as anticancer drugs.
9-[6-(Diphenylphosphino)pyridin-2-yl]-9H-carbazole: synthesis and coordination properties toward CuI and PdII
Authors: Baranov Andrey Yu , Bagryanskaya Irina Yu. , Artem’ev Alexandr Viktorovich
Published: January 2025

9-[6-(Diphenylphosphino)pyridin-2-yl]-9H-carbazole was synthesized in two steps involving cross-coupling of 2,6-dibromopyridine with carbazole followed by treatment of the formed monobromo pyridine derivative with Ph2PCl. The coordination properties of the synthesized ligand were demonstrated by the reaction with Pd(COD)Cl2 and CuI. The alkylation of the title compound with MeI proceeds selectively at the P atom to afford the corresponding phosphonium salt.
Magnetic nanocomposite catalysts for hydrogenation of organic compounds
Authors: Pomogailo Svetlana I. , Chepaikin Evgenii Grigor'evich , Tkachenko Olga P. , Bubelo Olga N. , Jussupkaliyeva Rosa I. , Kustov Leonid Modestovich
Published: January 2025

This brief review examines hydrogenation reactions catalyzed by magnetite-based nanocomposite catalysts. It is shown that these catalysts are environmentally friendly, recyclable and, due to the presence of magnetite in their composition, easily separated from the reaction medium.
Programy łagodzenia kar w polskim i amerykańskim prawie ochrony konkurencji a dostępność materiałów leniency dla osób dochodzących roszczeń odszkodowawczych w sprawach karteli i antykonkurencyjnych porozumień
Authors: Hansberry-Bieguńska Dorothy , Krasnodębska-Tomkiel Małgorzata , Materna Grzegorz
Published: January 2025

Tematem artykułu są kwestie związane z dostępem do dokumentów leniency w ramach dochodzenia roszczeń odszkodowawczych w sprawach porozumień ograniczających konkurencję w prawie polskim i amerykańskim. W zakresie prawa polskiego zostały przedstawione rozwiązania prawne zarówno obowiązujące, jak i projektowane w ramach implementacji unijnej dyrektywy odszkodowawczej (dyrektywa 2014/104/UE). Omawiane rozwiązania są przedmiotem analizy w aspekcie wpływu na skuteczność programów łagodzenia kar. Wynikające ze wspominanej dyrektywy przyszłe uregulowanie kwestii dostępu do materiałów leniency na potrzeby dochodzenia roszczeń odszkodowawczych może obniżać skłonność przedsiębiorców do składania wniosków leniency, a przez to skuteczność publicznoprawnego egzekwowanie reguł konkurencji. W związku z tym autorzy artykułu zgłaszają stosowne wnioski de lege ferenda. Jednocześnie, porównując w tym zakresie prawo polskie i USA, dochodzą do wniosku, że to w prawie amerykańskim relacje między prywatnoprawnym i publicznoprawnym egzekwowaniem naruszeń reguł konkurencji są ukształtowane tak, aby oba te narzędzia faktycznie ze sobą współdziałały, nie obniżając wzajemnie swojej skuteczności.
Szacowanie szkód powodowanych przez zmowy przetargowe
Authors: Piechucka Joanna , Stryszowska Marta
Published: January 2025

Niniejszy artykuł przedstawia poszczególne etapy oraz metody szacowania strat wynikłych z istnienia zmowy przetargowej. W pierwszej kolejności przedstawiono znaczenie oraz istotę opracowania scenariusza alternatywnego opisującego sytuację, jaka miałaby miejsce, gdyby do zmowy nie doszło.
Następnie przedstawiono techniczne oraz praktyczne aspekty stosowania poszczególnych metod szacowania strat. Omówiono metody porównawcze, analizę kosztów oraz metody symulacyjne. Opisowi poszczególnych metod towarzyszą przykłady ich stosowania. Wreszcie pokrótce omówiono względy praktyczne związane z wyborem odpowiedniej metody spośród wachlarza dostępnych metod pod kątem dostępności odpowiednich danych oraz weryfikacji wiarygodności przyjętych założeń.
International cooperation between Russia and Africa in countering transnational crimes at the present stage
Authors: Krehovets Aleksandra Viktorovna , Nikiforova Alena Anatol'evna
Published: January 2025

Currently, the issue of international cooperation in countering transnational crimes is quite relevant for all countries of the world, including the Russian Federation and the countries of the African continent. In addition, the relevance of the chosen area of international cooperation for scientific research is given by the strengthening of Russian-African relations over the past few years in the context of a changing geopolitical structure of the world, one of the areas of which is the issue of effective counteraction to the most widespread transnational crimes. The subject of the study is the international counteraction to transnational crimes within the framework of cooperation between Russia and the countries of the African continent. The purpose of the research is to study international cooperation between Russia and African countries in the field of countering transnational crimes at the present stage. The methods used in the research were general (dialectical method, systematic and integrated approaches) and special formal legal methods. In the course of the research, the following results were obtained: the signs of transnational crimes identified in international law were studied, as well as their additional characteristics were indicated, the approaches of foreign and domestic experts to the definition of "transnational crimes" were analyzed, the content of international cooperation in the field of countering crimes was studied, the basis for international cooperation in the field of countering transnational crimes was outlined, and the author's definition of the concept of "transnational crimes". The results obtained have a scientific novelty due to the fact that they clarify the content of the concept of transnational crimes and can be applied in the practical activities of various public authorities, primarily in improving mechanisms for countering transnational crimes at the level of international cooperation, as well as in the framework of scientific and representative events on the subject of research.
Comparison of Bicortical versus Unicortical Medial Malleolus Fixation
Authors: Lerch Ryan , Manway Jeffrey , Moloney Gele
Published: January 2025

Background: Ankle fractures continue to increase in incidence and severity in an older, more challenging geriatric population. Medial malleolus fixation with partially threaded cancellous 4.0-mm screws, a common fixation method, has been shown to fail due to pullout strength. Subsequent cadaveric models have shown increased pullout strength with the use of bicortical screws. The literature has also demonstrated fairly good clinical results with the use of bicortical screw fixation in a general population as well as in a complicated patient cohort.

Methods: We sought to compare bicortical fully threaded 3.5-mm screw fixation with unicortical partially threaded 4.0-mm fixation in medial malleolus fractures. The aim was to compare postoperative complications such as screw failure/loosening, nonunion, delayed union, painful hardware, time to union, and time to full weightbearing.

Results: Of 292 patients retrospectively reviewed, 126 were included following the inclusion and exclusion criteria. The data included 48 patients in the bicortical group and 78 in the unicortical group, with a mean ± SD combined age of 56.0 ± 18.0 years. Complications occurred in three patients (6%) in the bicortical screw fixation group and in six (8%) in the unicortical group, which did not reach statistical significance.

Conclusions: These results show that medial malleolus fixation has an overall low complication rate of 7% total combined, which is comparable with the current literature. We demonstrated no significant differences in complications, weeks to ambulation, or time to union between bicortical and unicortical fixation.
Electrophysiologic Evidence of Concomitant Focal Nerve Entrapments in Persons With Rheumatoid Arthritis: A Cross-Sectional Study
Authors: Nirenberg Michael S. , Segura Roberto P. , Segura Alex M. , Schnack Lauren L. , Forsthoefel Craig W. , Dachman Carey
Published: January 2025

Background: Although an association between peripheral nerve entrapment issues and rheumatoid arthritis (RA) has been found, research has generally focused solely on nerve entrapment in the upper or lower extremity individually rather than on the consideration of nerve entrapment simultaneously in the upper and lower extremities. In addition, most of these studies have used small sample sizes. The aim of this study was to evaluate the incidence of carpal tunnel syndrome (CTS) and tarsal tunnel syndrome (TTS) concurrently in patients with RA using a relatively large sample size.

Methods: A cross-sectional study using a nonprobability sampling method retrospectively surveyed the incidence of CTS and TTS in 338 patients with RA who had clinical signs of nerve entrapment and electrodiagnostic test evidence of CTS or TTS. The study comprised a sample of 269 women and 69 men.

Results: Electrodiagnostic testing found CTS in 256 patients (75.7%) and TTS in 82 patients (24.3%); CTS was found in 56 men and 200 women, and TTS was seen in 13 men and 69 women. Concurrent CTS and TTS occurred in 50 patients (14.8%; nine men and 41 women).

Conclusions: Peripheral nerve entrapment in the form of CTS and TTS was found to have a high incidence in persons with RA. The incidence of CTS and TTS occurring simultaneously in persons with RA was also found to be significant.
Enthesitis of Plantar Fascia Affects Gait in Patients With Ankylosing Spondylitis
Authors: Yentur Songul Baglan , Bilek Furkan , Deniz Gulnihal , Akgöl Gürkan , Koca Süleyman Serdar
Published: January 2025

Background: Many factors, such as decreased spinal mobility, pain, and dysfunction can affect gait parameters in patients with ankylosing spondylitis. The purpose of this study was to investigate the effects of plantar fascia enthesitis and disease-specific measurements on gait parameters in patients with ankylosing spondylitis.

Methods: The Win-Track platform was used to evaluate spatiotemporal parameters in patients with ankylosing spondylitis and in healthy controls. The Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), and Bath Ankylosing Spondylitis Function Index (BASFI) were used for disease-related parameters in patients with ankylosing spondylitis, respectively. Tendon thickness in the plantar fascia was measured using ultrasound to evaluate enthesitis.

Results: Thirty-one patients with ankylosing spondylitis and 31 healthy participants were included in the study. Cadence and step-cycle duration had a significant relationship with enthesitis for all regions and disease-related measurements. In addition, step length had a significant relationship with enthesitis for the midfoot and metatarsal bones, BASMI, and BASDAI; the left step length had a significant relationship with enthesitis in the calcaneus. The double-support phase had a significant relationship with enthesitis and BASMI. In the regression analysis, a significant relationship was found between BASDAI and step cycle time. A significant correlation was observed between all ultrasonographic parameters and cadence and stride cycle time values.

Conclusions: Impaired gait parameters were found in ankylosing spondylitis patients, and we concluded that plantar fascia enthesitis, function, disease activity, and spinal mobility affect gait parameters for these patients. Therefore, therapy for enthesitis, and adding foot rehabilitation to the routine program should be considered for patients with ankylosing spondylitis.
Acute Achille Tendon Rupture After Treatment of Levofloxacin for Helicobacter pylori Eradication: A Case Report
Authors: Şeker Aysun , Durmuş Nurdan Şentürk
Published: January 2025

This case report aims to demonstrate a rare occurrence of tendon rupture attributable to levofloxacin use in Helicobacter pylori eradication. On the seventh day of treatment, the patient experienced severe foot pain and difficulty in walking, leading to a diagnosis of Achilles tendon rupture confirmed through magnetic resonance imaging. Levofloxacin-induced tendinopathy and/or rupture are rare complications that are often linked to age and sex. Health-care providers should exercise caution when prescribing fluoroquinolones, especially to at-risk patients, and should inform them about potential side effects.
Automated cell annotation in multi-cell images using an improved CRF_ID algorithm
Authors: Lee Hyun Jee , Liang Jingting , Chaudhary Shivesh , Moon Sihoon , Yu Zikai , Wu Taihong , Liu He , Choi Myung-Kyu , Zhang Yun , Lu Hang
Published: January 2025

Cell identification is an important yet difficult process in data analysis of biological images. Previously, we developed an automated cell identification method called CRF_ID and demonstrated its high performance in Caenorhabditis elegans whole-brain images (Chaudhary et al., 2021). However, because the method was optimized for whole-brain imaging, comparable performance could not be guaranteed for application in commonly used C. elegans multi-cell images that display a subpopulation of cells. Here, we present an advancement, CRF_ID 2.0, that expands the generalizability of the method to multi-cell imaging beyond whole-brain imaging. To illustrate the application of the advance, we show the characterization of CRF_ID 2.0 in multi-cell imaging and cell-specific gene expression analysis in C. elegans. This work demonstrates that high-accuracy automated cell annotation in multi-cell imaging can expedite cell identification and reduce its subjectivity in C. elegans and potentially other biological images of various origins.
O impacto das GenAI na vida laboral nas organizações: um estudo com 526 adultos na região metropolitana do Recife
Authors: Silva Aparecida Regina Bezerra da , Carrilho Silvania Lucia da Silva , Silva Edson Soares da , Roazzi Antonio , Souza Bruno Campello de
Published: January 2025

Este estudo explora os impactos da Sofotecnia no ambiente laboral, analisando 576 trabalhadores da Região Metropolitana do Recife. A Sofotecnia, definida como a internalização de padrões cognitivos mediados por inteligências artificiais generativas (GenAI), mostra-se crucial para a adaptação às novas dinâmicas de trabalho. Foram analisadas variáveis sociodemográficas, traços psicológicos e características organizacionais em relação à Sofotecnia, produtividade e flexibilidade laboral. Os resultados mostram que 80% dos participantes já interagiram com GenAI, principalmente para aquisição de conhecimento (75,7%) e manipulação textual (67,5%). No entanto, apenas 22,6% das empresas possuem projetos formais de GenAI, indicando uso predominantemente informal. A Sofotecnia correlacionou-se positivamente ao desempenho laboral, com 80% dos trabalhadores mais sofotécnicos superando expectativas organizacionais, contra 27,6% dos menos sofotécnicos. Traços psicológicos como Inteligência Geral (r = 0,34) e Abertura à Experiência (r = 0,17) foram associados à Sofotecnia, enquanto Neuroticismo teve correlação negativa. Trabalhadores sofotécnicos relataram maior satisfação com recompensas e maior propensão ao trabalho remoto. Esses achados destacam a necessidade de estratégias de capacitação e políticas inclusivas para maximizar os benefícios da Sofotecnia, ao mesmo tempo que enfrentam desigualdades no acesso e riscos éticos. Governança da IA deve priorizar transparência, equidade e proteção de direitos trabalhistas para assegurar uma transição tecnológica sustentável.
Effects of Hearing Aids on Static and Subjective Balance in Patients With Hearing Loss: A Pilot Study
Authors: Kim Ga-Young , Cho Young Sang , Jo Mini , Yun Hee Jung , Quilter Megan , Kim Dae Young , Moon Il Joon
Published: January 2025

Background and Objectives: This study aimed to investigate the effects of hearing aids (HAs) on reducing symptoms of dizziness in patients with hearing loss (HL) and dizziness.Subjects and Methods: A pre- and post-intervention study was conducted between February 2022 and July 2022 at the outpatient clinic of a tertiary hospital in Seoul, South Korea. Ten participants (four males and six females) with HL and dizziness were recruited. Participants were screened using pure-tone audiometry and visual analog scale scores at baseline. Selected participants underwent the Modified Clinical Test of Sensory Interaction on Balance (mCTSIB) and Korean Dizziness Handicap Inventory (K-DHI) in the unaided state. Thereafter, participants were provided HAs and instructed to use them for at least 6 hours every day. At the 1-month follow-up, all participants were assessed in the aided state using the same tests as at baseline. All tests were performed bilaterally.Results: In the mCTSIB, a significant difference was observed in the foam surface-eyes closed score before (median=2.35) and after (median=2.2) HA use (p=0.049). No significant differences were observed in the K-DHI scores before and after HA use.Conclusions: HA use may improve the static and subjective perception of balance in patients with HL and dizziness. Future research should explore the benefits of HAs under various balance conditions such as dynamic balance and gait.
An Exploratory Study of Peripheral Vestibular System in Users of Personal Listening Devices
Authors: Dessai Teja Deepak , Kumar Kaushlendra , Bhat Rashmi J.
Published: January 2025

Background and Objectives: The widespread use of mobile phones and personal listening devices (PLDs) poses potential health risks, particularly noise-induced hearing loss. Among younger generations, high-volume PLD use is associated with auditory and vestibular system changes. Clinical vestibular testing, including vestibular-evoked myogenic potentials (VEMP) and the video head impulse test (vHIT), may reveal peripheral vestibular impacts from prolonged PLD exposure at volumes over 60%. This study examines VEMP and vHIT results in individuals with normal hearing who have had extended high-volume PLD exposure.Subjects and Methods: A cross-sectional comparative study was conducted on individuals aged 15-24 years. All the participants had normal pure tone thresholds with “A” type tympanogram, present acoustic reflexes, and history of PLD usage. Participants were divided into groups according to PLD exposure of <1 year (group A), 1.1-2 years (group B), 2.1-3 years (group C), and 3.1-4 years (group D). The output sound pressure level (dB SPL) near the tympanic membrane was measured. Furthermore, cervical VEMP, ocular VEMP, and vHIT were assessed.Results: The VEMP and vHIT findings were statistically analyzed and compared across groups. The peak-to-peak amplitudes of VEMP showed a statistically significant difference between groups A and D.Conclusions: Potential subclinical damage to the otolith organs can be associated with increased PLD exposure. No damage to the semi-circular canals was observed as the participants used lower dBA values by the PLDs.
Influence of Different Types of Contralateral Suppression Tones on Otoacoustic Emission in Children With Autism Spectrum Disorder
Authors: Jamal Fatin Nabilah , Dzulkarnain Ahmad Aidil Arafat , Basri Nadzirah Ahmad , Rahmat Sarah , Shahrudin Fatin Amira , Azemin Mohd. Zulfaezal Che , Sidek Shahrul Na’im , Yusof Hazlina Md , Hamid Siti Rafiah Abd.
Published: January 2025

Background and Objectives: Auditory sensory gating deficits are abnormalities in patients with autism spectrum disorder (ASD) that may lead to sensory processing difficulties. It is particularly difficult for children with ASD to distinguish multiple auditory stimuli, which hinders them from focusing on a single auditory stimulus and separating unnecessary sounds. Suppression of otoacoustic emission (OAE) is an approach used to identify sensory gating deficits in the general population, specifically for children with ASD. This study aimed to investigate the suppression effect of various types of sound suppressors to measure their sensory gating capacity in children with ASD.Subjects and Methods: Twenty children including 10 with ASD and 10 normally developing children aged 6-12 years were recruited for this study. One accessible ear was exposed to transient-evoked OAE, whereas the other was exposed to suppressor tones. Contralateral suppressors included white noise, Quranic recitations, environmental noise, and natural sound. The magnitude of OAE suppression was determined from the difference between the OAE amplitude with and without the masker (in dB sound pressure levels) for all sound types. The sound with the highest suppression effect was determined using effect size calculation and repeated-measures analysis of variance at a 95% confidence level. A high suppression effect may suggest a high sensory gating performance, whereas low suppression may indicate low sensory gating performance.Results: Based on the analysis, the sound with the highest suppression effect was that of the waterfall. The suppression results were supported by descriptive analysis findings and effect-size calculations.Conclusions: This study provides a better understanding of the alternative sound stimuli, besides the standard white noise tone, for the assessment of sensory gating deficits among children with ASD. Sounds with a high suppression effect have the potential to be used as sound therapy interventions for children with ASD as part of rehabilitation and therapy.
Supply Chain Management of Sago Noodle Production in Cempaka Healthy Noodle Business
Authors: Timisela Natelda R , Leatemia Ester D. , Huliselan Hlouke A
Published: January 2025

The aim of this study is to determine the marketing efficiency of sago noodle product at the Cempaka Healthy Noodle business. This study employed a survey method, using critical observation to obtain detailed information on a specific problem. The survey method used a questionnaire as a data collection instrument with MSME Cempaka Healthy Noodle as the sample, selected using purposive sampling. The results showed that in the SCOR analysis, the performance value of sago Cempaka noodle supply chain was 35.430 and was included in the poor criteria. In addition, the highest and lowest weights were on the plan and source criteria, accounting for 0.386 and 0.034, respectively. The results show that there are 5 performance assessment criteria used. The highest (0.386) and lowest weight (0.034) were in plan criteria and source criteria, respectively. This shows that the plan criteria were prioritized over others. The company considered the plan criteria as important and also the basis for other processes to run according to plan.
Preliminary Metabolomics and Determination of a Potent Anti-inflammatory Fraction of Freshwater Brown Algae
Authors: Ezinne Nwankwo Valerie , Juliet Muoegbunam , Chika Abba , B.C Okoye Festus , C Ugwu Chukwuebuka , G Ngwoke Kenneth
Published: January 2025

Objective: The study aims to perform preliminary metabolomics and identify the potent anti-inflammatory fractions from freshwater brown algae extract.
Materials and Methods: The brown algae sample was harvested from the exposed rocks in  Ebonyi River in Nigeria, and was subjected to cold maceration in a methanol-dichloromethane (2:1) solvent mixture for 72 hours, for extraction. The resulting extract was concentrated and subsequently fractionated via vacuum liquid chromatography (VLC) using solvent gradients of n-hexane and ethyl acetate. Acute toxicity was evaluated in Swiss albino mice according to Lorke’s method, with mortality rates employed to determine the LD50. The anti-inflammatory potential of the fractions was assessed using both in vitro (protein denaturation and heat-induced hemolysis assays) and in vivo (acetic acid-induced vascular permeability and xylene-induced edema) models. Doses of 50 and 100 mg/kg as well as 1 and 2 mg of the fractions (3:7, 5:5, 7:3) were administered orally and topical for the in vivo models respectively, while doses ranging from 62.5 to 1000 μg were used for the in vitro test. Dexamethasone was used as the positive control. High-performance liquid chromatography (HPLC) dereplication was employed to identify the phytoconstituents of the fractions.
Results: Many anti-inflammatory compounds, including quercetin, ellagic acid and Kaempferol were identified in the fractions which would have accounted for the pronounced anti-inflammatory properties observed. Fraction 5:5 showed a superior anti-inflammation compared to dexamethasone in the xylene-induced edema model, although not statistically significantly different.
Conclusion: These fractions, especially 5:5 can be further developed for the treatment of inflammation.