bluuebunny/crossref_metadata_2025 huggingface dataset:
THE ROLE OF MELATONIN IN COMPLICATED PREGNANCY
Authors: Pushkashu Anastasiya , Semeniak Alina
Published: August 2023

In recent years, there have been signiﬁ cant changes in the understanding of the hormone melatonin (MT). It has been conﬁ rmed that the processes of conception, pregnancy, and childbirth directly depend on the rhythm and level of MT secretion, but there is no general concept that could describe in detail the mechanisms of inﬂ uence on ontogenesis. The aim of the study. To assess MT in the blood of pregnant with retrochorial hematoma (RCH) up to 12 weeks of pregnancy.Material and methods. Two groups were formed: 1st – 40 pregnant women with RCH, 2nd control– 44 healthy pregnant. Obstetric research, enzyme immunoassay to determine MT, and ultrasound were performed. Statistical analysis according to generally accepted methods of variational statistics.The approval of the scientiﬁ c work was obtained from the Bioethical Commission of the Bukovinian State Medical University (Ukraine).Research results. A signiﬁ cant decrease of MT in the 1st group and the dependence of its level on the size of the RCH was revealed: in the case of hematomas up to 1 cm MT (59.31±10.32 pg/ml) (р ˂ 0.001), which is not observed in hematomas more than 1 cm, which are dangerous for pregnancy (93.98±14.52 pg/ml), which may indicate a compensatory increase in MT; and the term of pregnancy (in 10-12 weeks 79.03±9.61 pg/ml (р ˂ 0.05), in 5-6 weeks 93.78±17.44 pg/ml).Conclusions. In cases of RCH up to 1 cm the number of MT decreases with the development of pregnancy, which can be used as a prognostic marker for the diagnosis of pregnancy complications. The increase in the level of MT with RCH more than 1 cm can be considered as a compensatory increase for the preservation of pregnancy and a regulatory inﬂ uence on the further course of pregnancy.
N-Silylimine of Trifluoropyruvate in the Asymmetric Synthesis of Trifluoroalanine Derivatives
Authors: Cherednichenko Alona S. , Rassukana Yuliya V.
Published: August 2023

Aim. To develop a preparative method for the synthesis of N-trimethylsilylimine of trifluoropyruvate, and study its interaction with acetone under organocatalytic conditions.Results and discussion. A simple preparative approach to the first representative of N-silylimines of trifluoropyruvate was developed based on the interaction of triphenylphosphinimide and trifluoropyruvic acid methyl ester by the aza-Wittig reaction. It was found that the addition of acetone to N-silylimine occurred in the presence of L- or D-proline and led to the formation of enantiomerically enriched α-amino-γ-oxocarboxylates. The hydrolysis of the ester function resulted in (R)-α-trifluoromethyl aminocarboxylic acid, and the cyclocondensation with isocyanates or 2,5-dimethoxytetrahydrofuran yielded nitrogen-containing heterocycles containing pyrimidine or pyrrolizine nuclei.Experimental part. The synthetic procedures for the N-silylimine of trifluoropyruvate and its reaction with acetone are provided, along with the transformations of obtained α-amino-γ-oxocarboxylates (hydrolysis, cyclocondensations with isocyanates and 2,5-dimethoxytetrahydrofuran). The structures of the compounds synthesized were proven by 1H, 13C, 19F NMR spectroscopy methods, as well as by the elemental analysis.Conclusions. A convenient method for the synthesis of N-silylimine of trifluoropyruvate has been developed. Using the example of the Mannich reaction with acetone, it has been demonstrated that N-silylimine of trifluoropyruvate is a convenient substrate for the synthesis of optically active 3,3,3-trifluoroalanine derivatives.
PROPOSTA E APLICAÇÃO DE PROTOCOLO DE INSPEÇÃO RÁPIDA PARA PONTES DE MADEIRA
Authors: Damascena Matheus Silva , Morais Weslley Wilker Corrêa
Published: August 2023

A intensificação das relações comerciais entre as zonas rurais e urbanas contribui para a maior ocorrência da deterioração nas pontes de madeira. O protocolo de avaliação foi constituído por informações cadastrais, classificação da condição de obra e registro de anomalias. No total, 65,21% das pontes apresentaram condições excelentes e 13,04% apresentaram condições ruins e críticas.
Transtorno de estresse pós traumático - TEPT
Authors: Mello Marcelo Feijó de , Juruena Mario Francisco Pereira
Published: August 2023

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Psiquiatria da infância e da adolescência
Authors: Barbirato Fábio
Published: August 2023

Deficiência intelectual, transtorno do espectro autista, desvio de conduta e fobia social são temas tratados nessa discussão proporcionada pela ABP TV. A maioria dos transtornos psiquiátricos em adultos são desenvolvidos na infância e adolescência. Os transtornos identificados precocemente podem proporcionar uma vida adulta saudável.
Canabidiol
Authors: Garcia Frederico Duarte , Crippa José Alexandre de Souza
Published: August 2023

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Cyber Threats and Their Impact on the U.S. National Security
Authors: Lect.Jasim Muhammed Taha
Published: August 2023

The cyberspace has been turned into a new arena for the international struggle between the major powers in order to impose hegemony and influence on cyberspace, and these developments imposed a rethinking of the structure and the concept of national security of the state. As a result, the issue of cyberspace security became part of the national security strategies of many developed countries in order to prevent the exposure of their vital infrastructure to cyber threats and risks, and the United States is one of the first global powers to realize the importance of the impact of cyberspace on the global balance of power, as it considered it an essential element of the comprehensive forces of the state. Therefore, the United States focused on technological and information superiority in cyberspace in order to increase its strategic capabilities and deprive opponents of it within its national strategy for the twenty-first century. Since the cyberspace is one of the sources of threats facing the United States of America, it is necessary to develop several strategies to deal with threats and risks poses by cyberspace that threaten US national security.
Development experiences in Estonia, Latvia, and Lithuania after 2004
Authors: Assistant Lecturer Hind Ahmed Abd
Published: August 2023

This study examines the developmental experiences in the Baltic countries, namely Estonia, Latvia, and Lithuania, after 2004. Following their accession to the European Union, these countries underwent significant transformations in the fields of economy, population, and culture. The study aims to analyze the developmental changes in these countries and evaluate their impact on the assets of the population, their languages, and the population's developmental indicators and wealth.

The analysis revolves around the key aspects of development in these countries after 2004. The influence of these transformations on the assets of the population and their languages will be studied, with a focus on demographic changes and linguistic diversity. Additionally, the study will analyze population development indicators such as population growth rate, fertility rate, and mortality rate, to understand the population shifts in those countries.
Current treatments for tinnitus
Authors: Souza Gregory Lauar e , Nascimento Ana Luisa Pinho , Silva Bárbara Valadares Diniz , Sá Felipe Gonçalves de , Pereira Felipe Magno Alves , Buzollo Gabriela Ferreira , Carvalho Handerson Dias Duarte de , Lopes Laura Portelote Silva , Dias Samuel Filippe Motta Martins , Souza Cleiton Penna e
Published: August 2023

Objective: Explore tinnitus treatment approaches. Bibliographic review: Tinnitus is the perception of sound without an external source, impacting public health and correlating with depression. Medications (e.g., tricyclic antidepressants, benzodiazepines, anticonvulsants, melatonin) show some effectiveness in reducing tinnitus severity, but their efficacy is uncertain. Non-pharmacological therapies like cognitive-behavioral therapy (CBT) and tinnitus retraining therapy (TRT) hold promise in managing symptoms. CBT targets cognitive and behavioral aspects, while TRT combines sound therapy and counseling for habituation. Cochlear implant and stapes surgeries also improve tinnitus perception. Neuromodulation techniques (e.g., transcranial magnetic stimulation, transcranial direct current stimulation) are being explored, but research is needed for efficacy confirmation. Final considerations: Effective treatment options are crucial for tinnitus patients' quality of life. Pharmacological approaches (e.g., antidepressants, benzodiazepines, anticonvulsants) offer potential, although efficacy is uncertain. Non-pharmacological treatments like CBT, TRT, cochlear implantation, stapes surgery, and transcranial magnetic stimulation show promise in reducing tinnitus severity and improving well-being.
Tecnologias educacionais no cuidado pré-natal acerca das síndromes hipertensivas: revisão integrativa
Authors: Almeida Denise Comin Silva , Monteiro Amanda Suélen , Sehnem Graciela Dutra , Mello Giovana Batistella de , Cherubim Daiani Oliveira , Lemos Sabrina Madrid , Córdova Gabriella Dalla Corte , Santos Sibéli Castelani dos , Cogo Silvana Bastos , Fontoura Daiana de Paula
Published: August 2023

Objetivo: Analisar na literatura científica as tecnologias educacionais utilizadas no pré-natal para promoção da saúde gestantes com síndromes hipertensivas. Métodos: Revisão integrativa com buscas realizadas no portal de Biblioteca Virtual em Saúde, PubMed e PubMed Central. Resultados: dos 297 estudos encontrados, oito compuseram o corpus da pesquisa após aplicação dos critérios de seleção. Os estudos retratam a utilização de estratégias educativas por meio de tecnologias como aplicativo, instrumento impresso, exposição artística e educação em grupo para conscientização e cuidados por parte das gestantes relacionados à hipertensão arterial na gestação. Considerações finais: A informação de qualidade, adequada, científica e compartilhada em linguagem acessível tem potencial de qualificar os diagnósticos e tratamentos, além de viabilizar conforto e redução de processos danosos relativos à morbimortalidade materna. Compreende-se a importância da construção de discussões em ambientes acadêmicos e assistenciais sobre validação, implantação e avaliação da aplicabilidade de tecnologias que objetivam a promoção de saúde.
Mortalidade materna no estado do Pará: principais causas no período de 2017 a 2020
Authors: Figueira Simone Aguiar da Silva , Almeida Victória Pereira , Rêgo Naiandra Jociely Ferreira , Souza Pâmela Karen Oliveira de , Costa Alice Micaela da Silva , Cardoso Fernanda Jaqueline Teixeira , Ferreira Ilma Pastana , Freitas Jofre Jacob da Silva
Published: August 2023

Objetivo: Investigar as principais causas de Mortalidade Materna no Estado do Pará e calcular a Razão de Mortalidade Materna, no período de 2017 a 2020. Métodos: A pesquisa caracteriza-se por ser descritiva, retrospectiva, com abordagem quantitativa, com base em informações de dados coletados no Sistema de Informações de Mortalidade, disponibilizado pela Secretaria de Estado da Saúde Pública do Pará. Resultados: Dos 465 óbitos encontrados, destacaram-se as causas obstétricas diretas, especialmente as relacionadas às síndromes hipertensivas (33,1%) e às hemorragias (12%). A Razão de Mortalidade Materna encontrada no Estado foi de 84,3 durante os anos estudados e não houve redução significativa, sendo 2020 o ano que marcou a maior frequência de óbitos maternos, com 28% das mortes maternas, enquanto em 2018 ocorreram 21%. Conclusão: A taxa de óbitos evitáveis foi predominante, enfatizando as fragilidades da assistência obstétrica no Estado, bem como a necessidade de maior investimento na saúde da mulher.
Análise da automedicação entre os estudantes de medicina de uma faculdade privada do Sul da Bahia
Authors: Ramos Nayara Reis , Amorim Filho Mário Alves , Barreto Tatiana Ventin Ribeiro , Peixoto Vânia Costa dos Santos , Azevedo Fernanda Luiza Andrade de , Tourinho Luciano de Oliveira Souza
Published: August 2023

Objetivo: Analisar os fatores que influenciam o uso de medicamentos sem prescrição médica pelos acadêmicos de medicina de uma faculdade privada do Sul da Bahia. Métodos: Trata-se de estudo transversal, quantitativo, descritivo, com aplicação de questionário utilizando o Google Forms, aos acadêmicos do 1º ao 10º período, com consentimento prévio, conduzido com 207 indivíduos, ambos os sexos, idade de 17 a 48 anos. Os dados foram analisados pelo programa Microsoft Excel. O estudo foi aprovado por Comitê de Ética em Pesquisa. Resultados: A amostra foi composta por 207 discentes, 100% relataram fazer uso de medicamentos sem prescrição médica, os medicamentos mais utilizados foram os analgésicos/antipirético (81,2%) e anti-inflamatórios (74,4%), sendo os motivos mais apontados a cefaleia (84,1%) e gripe (72,5%). Além disso, 77,3% se automedicam em busca de alívio rápido dos sintomas. Observou-se que o uso de medicamentos sem orientação médica entre os estudantes é erroneamente influenciado pelos familiares (65,2%) e amigos/colegas (49,3%), sendo que 62,8% reconhecem que a automedicação é perigosa, entretanto, 79,7% continuariam se automedicando. Conclusão: Conclui-se ser alto o índice de acadêmicos que se automedicam, portanto, é relevante a reflexão sobre o tema, esperando dos profissionais da saúde o uso racional dos medicamentos.
Time and Labor Costs of Compression Therapy Wrap System for Lower Extremity Edema: Results From a Single Center
Authors: Mallow Peter , Chakravarthy Debashish , Pilati Louis
Published: August 2023

Introduction. Compression therapy is the standard of care for the treatment of lower extremity edema. However, compression therapy systems can be time-consuming to apply, which adds costs to the health care system and further strains human resources. Objective. The purpose of this study was to assess time and labor costs associated with the application of a 2LB versus 4LB compression therapy system. Materials and Methods. Time and labor cost data associated with the application of a 2LB system for the treatment of lower extremity edema of all etiologies were collected from a single high-volume wound care center located in Dayton, Ohio. The time and labor costs were compared to a 4LB system over the course of a single day (n = 38). Results. The application time and associated costs were 50% lower for the 2LB system. The expected savings of a 2LB compression system over the course of a month was 16:27 hours and $427 compared to a 4LB compression system, and the revenue gain was estimated at $15 210 revenue per month over the course of the month for the practice. Conclusion. The use of a 2LB compression system may be associated with substantial time and cost savings compared to a 4LB system.
Clinicomicrobiological Profile of Podiatric Infections: A Prospective, Cross-sectional Study
Authors: Holla V R Swathi , Bhat Sevitha , Bhat Archana , Shenoy Mulki Shalini
Published: August 2023

Introduction. Podiatric infections are common in patients with and without diabetes. Biofilm detection would aid in determining the severity of foot infections and preventive strategies to manage them. Objective. The authors studied the clinicomicrobiological profile of podiatric infections. Materials and Methods. Organisms from podiatric specimens were identified and the antibiotic susceptibility of the organisms determined using standard microbiological methods. Organisms were screened for biofilm production using the microtiter plate method. Staphylococcus aureus isolates were screened for ica, cna, and hlg genes by multiplex PCR. Results. A total of 117 patients were included in the study, and specimens from 71 patients were culture positive (60.6%). Gram-negative bacteria were predominant (n = 88 [73.3%]). S aureus (n = 32 [26.7%]) was the most common isolate. The rate of biofilm production was 54.2%. Pseudomonas aeruginosa was the most prevalent biofilm producer (82.8%). The study revealed a statistically significant association of biofilm formation with MDR, MRSA, and prior antibiotic therapy with multiple (≥4) antibiotics. Conclusion. Isolation of MRSA or MDR strain from diabetic foot infections could alert the clinician to the possibility of treatment failure with a single drug regimen owing to associated biofilm production. Detection of biofilm producers and subsequent early debridement and/or cleaning of wounds might prevent chronic infection.
Diagnostic Accuracy of a Fluorescence Imaging Device in Diabetic Wounds: A Pilot Study Using a Tissue Culture System
Authors: Koo Do-Yoon , Namgoong Sik , Han Seung-Kyu , Dhong Eun-Sang , Jeong Seong-Ho
Published: August 2023

Introduction. DFUs are challenging chronic wounds that are vulnerable to infections. A fluorescence imaging device was developed to detect bacterial presence in wounds. This device utilizes the principle that when illuminated by violet light, some bacteria emit red fluorescence and others, such as Pseudomonas aeruginosa, emit cyan fluorescence. Several studies have reported the accuracy of this device. However, to the best of the authors’ knowledge, no studies have examined the correlation between bacterial presence and tissue biopsy culture results in diabetic wounds. Objective. This study aimed to investigate the diagnostic accuracy of a fluorescence imaging device using a tissue culture system. Materials and Methods. Thirty-five patients (48 wounds) were included. Wounds were sampled using tissue culture methods and photographed using the fluorescence imaging device. Culture outcomes were categorized into non-Pseudomonas bacterial, Pseudomonas bacterial, both bacterial, and no-growth groups. Image outcomes were categorized into red, cyan, both colors, and negative groups. Results. For detecting the presence of bacteria, the fluorescence imaging device showed a sensitivity, specificity, PPV, and NPV of 64.1%, 55.6%, 86.2%, and 26.3%, respectively, with an accuracy of 62.5%. For P aeruginosa, the device showed a sensitivity, specificity, PPV, and NPV of 66.7%, 87.2%, 54.6%, and 91.9%, respectively, with an accuracy of 83.3%. For non-Pseudomonas bacteria, the device showed a sensitivity, specificity, PPV, and NPV of 43.8%, 62.5%, 70.0%, and 35.7%, respectively, with an accuracy of 50.0%. Conclusion. The fluorescence imaging device can help to detect the bacterial bioburden; however, its accuracy may be lower than that reported in previous studies of diabetic wounds.
A Unique Approach to Neurosurgical Wound Closure With Porcine Urinary Bladder Matrix: An Illustrative Case Series
Authors: Rahesh Jasmin , John Albin , Ronaghan Catherine
Published: August 2023

Introduction. PUBM is a non-synthetic, completely resorbable xenograft product with a myriad of uses, including management of burns, acute and chronic wounds, soft tissue reinforcement, and hernia repair. The material is available in both powder and sheet forms which allows for excellent coverage of irregularly shaped wounds. Case Report. The authors present 2 challenging neurosurgical wound cases. The first case is a large thoracolumbar wound secondary to a laminectomy complicated by a high output CSF fistula and dermal dehiscence. The second case is a deep postoperative surgical site infection in the setting of a large amount of surgical hardware. Both cases were successfully managed to complete wound healing with PUBM. Conclusion. Neurosurgical wounds can be technically challenging and difficult to manage. CSF fistulas lack evidence for standard treatment strategy, making complications and chronic wounds more likely. The application of PUBM in the closure of neurosurgical wounds has not been thoroughly studied and may lead to improved wound closure.
Aydın İli Bazı Tarım Makinaları İmalatçılarının İş Sağlığı ve Güvenliği Uygulamalarının Araştırılması
Authors: DURAN Elif , TOPUZ Nurettin
Published: August 2023

Bu araştırma 6331 sayılı İş Sağlığı ve Güvenliği Kanunu ve ilgili tebliğ ve yönetmelikler ışığındaki uygulamalar ile Aydın ilindeki bazı tarım makinaları imalatçılarının gerçekleştirmiş olduğu iş sağlığı ve güvenliği uygulamaları karşılaştırılarak eksikliklerin tespiti ve mevcut durumun belirlenmesi amacı ile yapılmıştır. Çalışmanın materyalini Aydın ili ve ilçelerinde bulunan Sanayi Odası ve Söke Ticaret Odası’nda kayıtlı tarım makinaları imalatı yapan 19 işletme oluşturmaktadır. Veri toplama aracı olarak 68 sorudan oluşan yüz yüze gerçekleştirilen anket yöntemi kullanılmıştır. Anketlerden elde edilen veriler bilgisayar ortamında EXCEL programı kullanılarak değerlendirmeleri yapılmıştır. Araştırma; katılımcıların demografik özellikleri, işletme yapıları, üretim bölümleri, iş sağlığı ve güvenliği uygulamalarına ilişkin bilgileri ve iş kazaları ve meslek hastalıklarına yönelik işletmeler çerçevesinde elde edilen verilerden oluşmaktadır. İncelenen tarım makinaları imalatçılarının genel olarak iş sağlığı ve güvenliği uygulamalarını yerine getirdikleri görülmüş fakat birtakım eksiklikler tespit edilmiştir. Ankete katılan firma sorumlularının iş sağlığı ve güvenliği kanunu hakkında bilgi eksikliği yaşadıkları, firmalarda önlemlerin uygulanma düzeyinin yeterli seviyede olmadığı, işveren ve çalışan yükümlülüklerini tam anlamıyla bilmediği, kontrol ve denetimlerin etkin bir şekilde yapılmadığı şeklinde eksiklikler görülmüştür.
Formulasi salep ekstrak ikan gabus (Channa striata) dan madu kelulut (Heterotrigona itama) dengan bahan pengikat carbopol
Authors: Livia Livia , Andrie Mohamad , Taurina Wintari
Published: August 2023

Latar belakang: Salep yang mengandung ekstrak ikan gabus dan madu kelulut terbukti mendukung penyembuhan luka. Sediaan salep pada penelitian sebelumnya menyatakan bahwa adanya ketidakstabilan pada sediaan. Hal ini ditandai dengan terjadinya pemisahan fase, dan ditambahkan carbopol untuk mencegah pemisahan. Tujuan penelitian ini berguna memperlihatkan sifat fisik salep ketika ditambahkan carbopol sebagai peningkat kosistensi sediaan terhadap sifat fisik salep. Metode: Variasi konsentrasi carbopol terdiri dari F1 (carbopol 0,5%), F2 (carbopol 1%) dan F3 (carbopol 2%). Evaluasi yang dilakukan yaitu uji evaluasi fisik kemudian dianalisa dengan bantuan SPSS. Hasil: Konsentrasi carbopol yang semakin tinggi menghasilkan daya sebar semakin kecil dan daya lekat semakin besar. F1 memiliki rata-rata daya sebar terbesar yaitu 3,40 cm. F3 memiliki rata-rata daya lekat terbesar yaitu 969,33 detik. F3 memiliki rata-rata pH terbesar yaitu 6,04. Analisis SPSS menunjukkan semua formula yang mengandung carbopol memiliki nilai daya sebar dan daya lekat berbeda signifikan dengan formula kontrol dan F1, sedangkan nilai pH berbeda signifikan dengan F2. Kesimpulan: F3 menghasilkan sediaan salep yang baik dan sesuai persyaratan dengan nilai daya sebar 2,72 cm, daya lekat 969,33 detik, pH 6,04, memiliki daya proteksi yang baik dan sediaan homogen.
UJI_VALIDITAS_DAN_RELIABILITAS_BRIEF_ILLNESS_PERCEPTION QUESTIONNAIRE_(B-IPQ)_VERSI_INDONESIA_PADA_PASIEN_TUBERKULOSIS PARU_DI_PUSKESMAS_NANGA_PINOH_KABUPATEN_MELAWI
Authors: Saputri Mischely Widnijustin , Purwanti Nera Umilia , Nurmainah Nurmainah
Published: August 2023

Latar-Belakang:-Tuberkulosis-paru-adalah-penyakit-kronis-yang.menular,dan.membutuhkan lama-terapi-pengobatan-minimal-selama-6,bulan.-Lamanya.waktu.terapi,pengobatan.selama.6 bulan mempengaruhi.persepsi,pasien,terhadap-penyakit-yang-dideritanya.-Instrumen-B-IPQ-(Brief-Illness Perception-Questionnaire)-merupakan-kuisioner-singkat-terdiri-dari-9-item-yang-digunakan-.untuk mengukur.-,persepsi,-.penyakit,-.yang-.diderita..-oleh,.-pasien.-.Instrumen.-B-IPQ-.versi-..Indonesia perlu.-dilakukan.-uji.-reabilitas.-dan-,validitas.-agar,-data-,pada-,instrumen,-tersebut-,valid-,reliabel dan,-dapat,-dipertanggungjawabkan.-Instrumen-B-IPQ-ini-belum-pernah-dilakukan-penelitian-pada pasien-,tuberkulosis,-paru.-Tujuan:-,Mengetahui,-reabilitas-,dan-,validitas,-instrumen-B-IPQ-.versi Indonesia,-pada.-,pasien.,-tuberkulosis.,-paru-,.di-..Puskesmas-,Nanga-,Pinoh-,Kabupaten.-,Melawi. Metode:-Pada.-penelitian-.ini-digunakan-metode.-observasional-survei-analitik-dengan-pendekatan potong.-lintang.-(cross-sectional).-,Sampel-,yang-,digunakan,-adalah-.40-orang-pasien-tuberkulosis paru-,/dengan-/,teknik-/,purposive,-/sampling./- Uji-,/validitas,-/dilakukan-,/dengan-,/menggunakan metode/-Pearson-,correlation-,(nilai,-korelasi-≥-0.312),-dan-,uji-reliabilitas-,menggunakan.-,teknik Internal-.consistency.-(Cronbach-alpha-coefficient-≥-0.7).-Hasil:-Hasil-.pada-.penelitian-ini-adalah uji-,.validitas.-menunjukkan.-bahwa-.nilai.-korelasi-.item->-0.312-(0.05),-dan-,hasil-,uji-,reliabilitas menunjukkan,-.-nilai,-.-Cronbach,-.-alpha-,.coefficient,.-adalah,.-0.723->-0.7-(0.05).-,Kesimpulan: Kesimpulan,-penelitian,-ini-,adalah-,instrumen,-B-IPQ-,versi-,Indonesia,-valid-,dan-,reliabel,-untuk mengukur=.persepsi=.penyakit.=pada=.pasien=.tuberkulosis=,paru,=-di-,-Puskesmas.-Nanga-.Pinoh Kabupaten-,Melawi-,sehingga,-dapat-,digunakan-,untuk-,mendeskripsikan-seluruh-,persepsi-,pasien terhadap-rasa-sakit-dari-penyakit-yang-dideritanya.
The Training of Machine Learning Potentials for Reactive Systems: A Colab Tutorial on Basic Models
Authors: Pan Xiaoliang , Snyder Ryan , Wang Jia-Ning , Lander Chance , Wickizer Carly , Van Richard , Chesney Andrew , Xue Yuanfei , Mao Yuezhi , Mei Ye , Pu Jingzhi , Shao Yihan
Published: August 2023

In the last several years, there has been a surge in the development of machine learning potential (MLP) models for describing molecular systems. We are interested in a particular area of this field — the training of system-specific MLPs for reactive systems — with the goal of using these MLPs to accelerate free energy simulations of chemical and enzyme reactions. To help new members in our labs become familiar with the basic techniques, we have put together a self-guided Colab tutorial (https://cc-ats.github.io/mlp_tutorial/), which we expect to be also useful to other young researchers in the community. Our tutorial begins with the introduction of simple fitting neural network (FNN) and kernel-based (using Gaussian Process Regression, GPR) models by fitting the two-dimensional Müller-Brown potential. Subsequently, two simple descriptors are presented for extracting features of molecular systems: symmetry functions (including the ANI variant) and embedding neural networks (such as DeepPot-SE). Lastly, these features will be fed into FNN and GPR models to reproduce the energy/force of molecular configurations of the Claisen rearrangement.
A Conjoined Rectilinear Collision Cell and Pulsed Extraction Ion Trap with Auxiliary DC Electrodes.
Authors: Stewart Hamish , Grinfeld Dmitry , Wagner Alexander , Kholomeev Alexander , Biel Matthias , Giannakopulos Anastassios , Makarov Alexander , Hock Christian
Published: August 2023

Ion traps are routinely directly coupled to mass analyzers, where they serve to suitably cool and shape an ion population prior to pulsed extraction into the analyzer proper. Such devices benefit from high duty cycle and transmission but suffer slow ion processing times caused by compromise in the buffer gas pressure range that suitably dampens injected ion kinetic energy, without causing excessive scatter during extraction or within the analyzer. A rectilinear RF quadrupole ion trap has been characterized, conjoining a pressurized collision region with a pumped extraction region, and an unbroken RF interface for seamless ion transfer between them. Auxiliary electrodes mounted between the RF electrodes provide DC voltage gradients that serve to both guide ions through the device and position them at the extraction slot. The influence of the auxiliary DC upon the trapping RF field was measured, and suitable parameters defined. A mode of operation was developed that allowed parallel processing of ions in both regions, enabling a repetition rate of 200Hz when the device was coupled to a high-resolution accurate-mass analyzer.
Influencia del Programa Pensión 65 en el bienestar de los usuarios en la Provincia de Chupaca 2020 – 2021
Authors: Rivera Medrano José Luis
Published: August 2023

El Objetivo de la investigación fue determinar de qué manera influye el Programa Pensión 65 en la calidad de vida de los usuarios de la provincia de Chupaca 2020 – 2021. El diseño de la investigación fue no experimental porque no se manipulará variables. Siendo un estudio descriptivo, con corte transversal se realizó en un tiempo determinado (2020-2021). La población que estudiamos estuvo compuesta por 1638 usuarios y una muestra de 287 usuarios por criterio de exclusión e inclusión. Utilizamos la encuesta como técnica luego dos instrumentos, dos cuestionarios: primero con contestación dicotómica para Programa P65, segundo cuestionario con escala de varias contestaciones politómica para calidad de vida. Validamos nuestro instrumento por juicio de Expertos, para analizar nuestra relación de variables aplicamos el coeficiente de Rho de Spearman = .050. En nuestros resultados llegamos a la conclusión, que la variable Pensión 65 influye en el bienestar de vida a través de la seguridad económica en los usuarios pertenecientes a la provincia de Chupaca – Junín 2020 - 2021 se presenta que el grado de significatividad, p <0.05 y coeficiente Rho de Spearman =  .660 con una varianza del Programa P65 y bienestar de vida con una influencia en 0,01 %.
On Covert Civil Disobedience and Animal Rescue
Authors: Weltman Daniel
Published: August 2023

Tony Milligan argues that some forms of covert non-human animal rescue, wherein activists anonymously and illegally free non-human animals from confinement, should be understood as acts of civil disobedience. However, most traditional understandings of civil disobedience require that the civil disobedient act publicly rather than covertly. Thus Milligan’s proposal is that we revise our understanding of civil disobedience to allow for covert in addition to public disobedience. I argue we should not. Milligan cannot justify using paradigm cases to expand the scope of civil disobedience without justifying similar reasons to limit the scope, and he does nto give convincing reasons for discarding the communication requirement, according to which an action cannot count as civil disobedience unless it is communicative. The immediate conclusion is that animal rescue is not civil disobedience, while the broader conclusion is one about civil disobedience more broadly: an act must be public to count as civil disobedience.
The solvents influence in the continuous extraction to antioxidant and αglucosidase inhibition of Cinnamomum burmannii bark
Authors: Ervina M. , Diva J. , Caroline  , Soewandi A.
Published: August 2023

The proanthocyanidins, the polyphenolic compounds from Cinnamomum burmannii
(Lauraceae), have been known for their insulin-like effects. The different use of solvents
and extraction methods would influence the bioactive phytochemicals. This research
examined the solvents used in the continuous extraction method to provide a higher yield
of bioactive extracts. The use of ethanol only compared to the gradual polarity of nhexane, ethyl acetate, and ethanol in the soxhletation to the standardized dried cinnamon
bark. The extracts were then analyzed for their total phenolic content, antioxidant, and αglucosidase inhibition. The extracts contained essential oils, tannins and flavonoids,
triterpenoids, coumarins, and glycosides. The ethanolic solvent provides a higher yield
and total phenolic content compared to other extracts. The ethanolic extracts phenolic
content was highest, and its IC50 DPPH antioxidant activity was no significant difference
from rutin. The IC50 α-glucosidase inhibition of most extracts was lower than acarbose,
thus classified as vital to moderate activity. The correlation analysis preceded a negative
result of total phenolic content to α-glucosidase inhibition activities. These results
supported the beneficial use of C. burmannii bark ethanol extract as α-glucosidase
inhibitor and oxidative stress relieving in diabetes dietary supplements.
The use of aromatic aldehydes for the test determination of cefotaxime
Authors: Kozhinova E. S. , Tumskaia A. V. , Kosyreva I. V.
Published: August 2023

Indicator papers based on immobilized reagents with their subsequent digital image processing are widely used for the quick and cheap screening study of drugs when assessing the content of the main substance in drugs for the presence of counterfeits. Indicator papers based on reagents immobilized on a cellulose matrix 4-dimethylaminocinnamic aldehyde (DMACA), 4-dimethylaminobenzaldehyde (DMAB), and 3-methoxy-4-hydroxybenzaldehyde (vanillin) were proposed for the determination of β-lactam antibiotic cefotaxime. To specify optimal conditions for the immobilization of reagents on a solid matrix, the intensities (changes in intensities) of color parameters were recorded at a different concentration of reagents, type of surfactants, and paper porosity. The detection limits of visual-colorimetric determination of cefotaxime were 1.0 mg/ml (DMACA), 0.12 mg/ml (DMAB), and 0.30 mg/ml (vanillin). Colorimetric processing of images of the test agents was carried out in the GIMP (GNU Image Manipulation Program) 2.10 program by averaging the images of indicator papers using the blur-sharp function, determining the intensity of color parameters. The photos were taken using a 48-megapixel camera of a POCO X3 pro smartphone in a specialized box measuring 22 × 23 × 24 cm with two LED lighting strips (5 V, 1 A). Linear dependences of the intensities of color parameters of the RGB, HSV, and CMYK models on the cefotaxime concentration (log c) were obtained: y = –15x + 45 (r2 = 0. 99, color parameter H for DMACA), y = –51x + 130 (r2 = = 0.99, parameter B for DMAB), y = 36x + 30 (r2 = 0. 99, S parameter for vanillin). Linear dependences of the areas and perimeters of the petal diagrams of indicator papers on the cefotaxime concentration have been plotted for the studied systems of cefotaxime — immobilized reagent. The correctness of the determination results was assessed using the analysis of spiked samples, the relative error did not exceed 25%. The developed test tools based on immobilized aromatic aldehydes are recommended for the semi-quantitative determination of cefotaxime.
Analisis Tensil Strength Dan Micro Structure Pada Hasil Las Plat Besi Strip Dengan Variasi Jenis Ampare
Authors: Anam Mohammad Soiqul , Dika Johan Wayan , Putra Hardiansah Satria
Published: August 2023

Abstrak

Dalam rangka meningkatkan daya saing industri tingkat regional maupun internasional. Industri manufaktur merupakan industri yang banyak menyerap tenaga kerja, teknologi pengelasan menjadi sangat penting karena sebagian besar pada industri manufaktur menggunakan teknik pengelasan. Penelitian ini bertujuan untuk mengetahui pengaruh variasi arus pengelasan terhadap kekuatan tarik dan micro structure pengelasan SMAW dengan elektroda RB-26  pada pelat Besi Strip dengan ketebalan 06 mm. Besar variasi penggunaan arus las adalah 75 amp, 85 amp, 95 amp. Penelitian ini adalah dilakukan dengan membuat uji spesiment dengan variasi arus las sebesar 75 ampere, 85 ampere, 95 ampere, selanjutnya dilakukan pengujian spesiment uji tarik dan foto mikro untuk mencari informasi pengaruh yang disebabkan oleh variasi arus las terhadap kekuatan tarik dan micro structure. Hasil penelitian menunjukkan bahwa kekuatan tarik tertinggi (Ultimate Tensile Strength) diperoleh pada asampel sebesar 95 ampere dengan nilai rata – rata UTS sebesar 3624.9MPa.

Katakunci: Las SMAW, Ampare, uji Tarik, structure mikro

 

Abstract

In order to increase the competitiveness of the industry at the regional and international levels. The manufacturing industry is an industry that absorbs a lot of labor, welding technology is very important because most of the manufacturing industry uses welding techniques. This study aims to determine the effect of variations in welding current on tensile strength and microstructure of SMAW welding with RB-26 electrodes on Iron Strip plates with a thickness of 06 mm. Large variations in the use of welding currents are 75 amps, 85 amps, 95 amps. This research was carried out by making specimen tests with variations in welding currents of 75 amperes, 85 amperes, 95 amperes, then tensile test specimens and micro photos were carried out to find information on the effects caused by variations in welding currents on tensile strength and micro structure. The results showed that the highest tensile strength (Ultimate Tensile Strength) was obtained at samples of 95 amperes with an average UTS value of 3624.9 MPa.

Keywords: SMAW welding, Ampere, Tensile test, micro structure
Efisiensi Waktu Pemberian Pakan Ayam Pada Mesin Hopper
Authors: Romadhoni Ahmad
Published: August 2023

Telur merupakan bahan makanan hasil ternak unggas yang sangat bernilai gizi tinggi karena semua golongan menyukai dan sadar dengan pentingnya makanan - makanan bergizi dan diminati tanpa batasan usia dan setatus ekonomi, para peternak ayam petelur sering terkendala manajemen pemeliharaan pakan terutama berkaitan dengan pemberian pakan ternak permasalahan tersebut dapat diatasi dengan teknologi peternakan.Teknologi pemberian pakan menggunakan mesin hopper. Penggunaan mesin hopper perlu dihitung efisiensinya.Penghitungan efisiensi pemberian pakan dapat dilakukan dengan metode true exsperimental researh.Waktu penelitian ini dilaksanakan pada bulan September – Oktober di Desa Candirejo Kecamatan Ponggok.Berdasarkan penelitian yang sudah dilakukan didapatkan hasil efisiensi waktu sebesar 33,6 m/s dan diperoleh efisiensi kecepatan sebesar 0,15 m/s dengan panjang kandang 23 meter.Tujuan penelitian ini untuk mengetahui perbandingan  efisiensi waktu pemberian pakan ayam menggunakan metode  manual dan metode otomatis.
Efek Suplementasi Tepung Semangka dalam Pakan Terhadap Kualitas Interior Telur Ayam Kampung
Authors: Haryuni Nining , Syafi'ina Syafina , Lidyawati Anna , Lestariningsih -
Published: August 2023

The purpose of this study was to determine the effect of watermelon seed flour supplementation in feed on the interior quality of native chicken eggs. This research is a biological research using Completely Randomized Design (CRD) with 4 treatments and 5 replications. Each treatment used 5 chickens. The results of statistical analysis showed that watermelon seed flour supplementation in feed had a very significant effect (p<0.01) on the egg yolk index and egg white height and had an insignificant effect (p>0.05) on the egg index. The conclusion of this study is that watermelon seed flour supplementation can improve the interior quality of native chicken eggs. The best supplementation dose at 0.10%.
Pengaruh Waktu Pemanasan Sebelum Inkubasi Terhadap Kualitas Telur Tetas Ayam Buras
Authors: Haryuni Nining , Fathoali M. , Lidyawati Anna , Lestariningsih -
Published: August 2023

The purpose of this study was to determine the effect of heating before incubation on the quality of native chicken hatching eggs. This study used 200 eggs from native chickens. This research is a laboratory research using Completely Randomized Design (CRD) with 4 treatments and 5 replications. Each treatment used 10 hatching eggs. If statistical analysis shows a significantly different or very significant effect, it will be continued by using Duncan's test. In this study, the results showed that heating of hatching eggs before incubation had a very significant effect (p<0.01) on fertility and hatchability, but had an insignificant effect (p>0.05) on weight loss of hatching eggs. The average egg weight loss in this study ranged from 0.00-0.10%, fertility 70.94-83.15%, embrio mortality 15-40% and hatchability ranged from 60-85%. Based on the results of the study, it can be concluded that the heating of the hatching eggs before the eggs are put into the incubator can reduce the quality of the hatching eggs. The longer heating time causes the lower quality of hatching eggs.
Evaluasi Organoleptik Bakso Daging Joper yang Diberi Pakan Tepung Maggot Selama Pemeliharaan
Authors: Ridho M. Rosichan Ridho , Lestariningsih Lestariningsih , Haryuni Nining
Published: August 2023

Tujuan penelitian ini adalah untuk mengevaluasi organoleptik (warna, rasa, tekstur, dan kekenyalan) bakso daging ayam joper dengan subtitusi tepung maggot pada pakan selama pemeliharaan. Materi yang digunakan dalam penelitian ini adalah 60 sampel daging ayam joper yang dipanen saat umur 51 hari dengan subtitusi tepung maggot yang berbeda pada ransum. P0: Tepung ikan 15% + Tepung maggot 0% , P1: Tepung ikan 11,25% + Tepung maggot 3,75%, P2: Tepung ikan 7,5% + Tepung maggot 7,5%, P3: Tepung ikan 0 % + Tepung maggot 15%. Enam ekor ayam dari masing-masing perlakuan diambil karkasnya untuk pembuatan bakso . Pengujian kualitas organoleptik bakso antara lain warna, rasa, tekstur, dan kekenyalan. Data yang diperoleh dari penelitian ditabulasi dan dianalisis menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari 4 perlakuan dan 3 ulangan apabila terdapat perbedaan pengaruh yang nyata atau sangat nyata dilanjutkan dengan uji Duncans. Hasil dari penelitian menunjukkan bahwa subtitusi tepung maggot yang berbeda-beda dalam ransum tidak memberikan pengaruh nyata terhadap uji organoleptik yang meliputi warna, rasa, tekstur dan kekenyalan. Penelitian ini dapat disimpulkan bahwa bakso daging joper yang diberi pakan tepung maggot dengan level berbeda-beda selama pemeliharaan dapat diterapkan pada pembuatan bakso dengan tidak merubah organoleptik bakso.

Katakunci:Bakso daging joper, Evaluasi organoleptik,Pakan, Tepung maggot
Pengaruh Penggunaan Tepung Maggot dalam Pakan terhadap Organ Visceral Ayam Joper
Authors: Hadi Fuad Samsul
Published: August 2023

Upaya perbaikan pemberian pakan dalam menciptakan ransum pakan ayam joper yang memiliki nutrisi yang tinggi untuk konsumsi ayam joper dapat dilakukan melalui pemanfaatan sumber daya local sebagai subtitusi pakan dalam ransum. Ransum yang diberikan adalah sumber energi utama untuk ternak dapat mempertahankan hidupnya melalui peningkatan nutrisi didalamnya dengan pemanfaatan sumber daya local sebagai bahannya. Sumber nutrisi utama untuk otak dapat bekerja secara optimal berasal dari energy metabolis pakan. Kenyataannya penelitian tentang pengaruh pemanfaatan tepung maggot pada pakan ayam joper terhadap kualitas organ visceral ayam joper yang meliputi usus, gizzard, hati, proventikulus, lemak abdomen tidak berpengaruh signifikan karena banyak factor diantaranya bentuk pakan.

Katakunci: pakan ayam, joper, energy, dan organ visceral.
Pengaruh Jumlah Elektrode Pada Konfigurasi Sensor IDCS Terhadap Pengukuran Permitivitas Parafin dan Glycerol
Authors: Khasanah Ulfa Niswatul
Published: August 2023

Abstrak

IDCS adalah sensor kapasitif dengan ukuran kecil dan tipis yang digunakan untuk mengukur permitivitas bahan. Jenis bahan yang dapat diukur meliputi zat cair, gas dan zat padat yang berbentuk serbuk. IDCS terdiri dari lapisan tembaga yang memiliki pola atau konfigurasi seperti sisir yang menempel pada lapisan substrat FR-4. Konfigurasi tersebut meliputi lebar electrode (a), jarak antara dua electrode (b), panjang electrode (L) dan jumlah electrode (N). setiap komponen tersebut memiliki pengaruh terhadap hasil pengukuran permitivitas bahan. Sehingga untuk mendapatkan alat ukur permitivitas yang optimum maka diperlukan penelitian tentang masing-masing pengaruh dari komponen tersebut. Penelitian ini membahas tentang pengaruh jumlah elektrode pada konfigurasi sensor IDCS. Variasi jumlah elektroda ysng digunakan yaitu 3, 4, 5, 6, dan 7. Jumlah tersebut mengacu pada hasil optimasi menggunakan metode Particle Swam Optimization (PSO). Konfigurasi yang paling optimum diperoleh dari hasil pengukuran dengan eror yang terkecil. Kesimpulan pada penelitian ini yaitu semakin besar jumlah elektroda maka semakin besar pula kapasitansinya. Nilai kapasitansi tidak berbanding lurus dengan nilai permitivitas, hal ini disebabkan oleh konfigurasi IDCS yang berbeda. Pada pengukuran permitivitas udara, parafin dan glycerol terdapat 1 kesamaan yaitu konfigurasi yang memiliki eror terkecil adalah N6 dengan a = b = 2 mm, L= 5 cm, N = 6 dan h = 1µm.

 

Katakunci: IDCS, kapasitor, permitivitas
PENERAPAN K-MEANS CLUSTER DI PROVINSI JAWA TIMUR BERDASARKAN KETAHANAN PANGAN
Authors: ARINI EWING RUDITA
Published: August 2023

Pangan merupakan kebutuhan utama yang harus dipenuhi masyarakat. Jika ketahanan pangan terganggu, maka akan berdampak buruk bagi kehidupan bangsa. Analisis K-Means Cluster adalah salah satu metode pada Analisis Cluster non hirarki yang mengelompokkan data ke dalam satu atau lebih kelompok. Data-data yang mempunyai karakteristik yang sama dikelompokan dalam satu cluster dan data yang mempunyai karakteristik yang berbeda dikelompokan ke dalam cluster yang lain. Data-data yang digunakan pada penelitian ini adalah luas panen padi, produktivitas padi dan produksi beras pada 38 Kabupaten/Kota di Provinsi Jawa Timur tahun 2022. Ada tiga kelompok yang terbentuk yaitu Kabupaten/Kota dengan ketahanan pangan yang diduga rendah sebanyak 23 anggota, sedang sebanyak 9 anggota dan tinggi sebanyak 6 anggota.
ANALISIS KELAYAKAN USAHA TERNAK KAMBING BK JAYA FARM NGADIREJO KABUPATEN NGANJUK
Authors: Putra Ebim Pradana , Yuniati Erna , Andaruisworo Sapta
Published: August 2023

Penelitian ini bertujuan untuk menganalisis besarnya kelayakan usaha ternak kambing BK Farm Nganjuk. Dan menganalisis faktor-faktor yang berpengaruh terhadap kelayakan usaha ternak kambing BK Farm Nganjuk. Pendekatan dan jenis penelitian yang digunakan dalam penelitian ini adalah pendekatan deskriptif kuantitatif. Kesimpulan dari penelitian ini adalah kelayakan usaha BK Jaya Farm Nganjuk didapat dari penjualan kambing. Kelayakan usaha BK Jaya Farm Nganjuk adalah Rp 174.731.432. Hasil dari perhitungan analisis finansial menunjukkan nilai Net Present Value yaitu sebesar Rp 314.732.460. Hal ini menunjukkan bahwa usaha ini layak dijalankan selama 5 tahun karena menunjukkan Net Present Value yang positif. Titik impas (Break Event Point) akan tercapai jika BK Jaya farm menjual kambing dengan harga Rp. 1.115.000/ekor. Usaha ternak kambing BK Jaya Farm layak untuk dijalankan.
Effect of nitric oxide delivery on energy supply of renal tissue in cardiopulmonary bypass: an experimental study
Authors: Tyo M. A. , Kamenshchikov N. O. , Podoksenov Yu. K. , Mukhomedzyanov A. V. , Maslov L. N. , Kozlov B. N.
Published: August 2023

Introduction. Acute kidney injury is a common complication of cardiac surgery with cardiopulmonary bypass. Ischemic-reperfusion injury, systemic inflammation, oxidative stress, and other factors that occur during cardiopulmonary bypass lead to disruption of energy supply and death of kidney tissue cells. Delivery of nitric oxide is a promising method of nephroprotection during cardiosurgical operations with cardiopulmonary bypass.

Aim: To study the parameters of energy supply of the renal tissue during cardiopulmonary bypass with nitric oxide delivery in the experiment.

Material and Methods. A prospective controlled experimental study was performed on 12 rams. Animals were included in 2 equal groups at a ratio of 1:1. In the main group, nitric oxide was delivered at a dose of 80 ppm immediately after tracheal intubation and within 90 minutes of cardiopulmonary bypass (main group, n = 6). In the control group, mechanical ventilation and cardiopulmonary bypass were performed according to standard protocols (control group, n = 6). Biopsy specimens of kidney tissue were taken 1 hour after weaning from cardiopulmonary bypass. Energy supply was assessed (according to the tissue concentration of adenosine triphosphate (ATP) and lactate).

Results. Delivery of nitric oxide was not accompanied by tissue perfusion aberration during cardiopulmonary bypass (CPB). The level of free hemoglobin in both groups was statistically significantly higher 1 hour after cardiopulmonary bypass compared with the stages of intubation – p < 0.000... and the beginning of CPB – p < 0.000... The ATP value significantly differed between groups and amounted in the control group 3.7 ± 0.62 nmol/g; in the main group 6.8 ± 1.11 nmol/g, р = 0.00011. The lactate concentration did not differ statistically significantly between the groups and amounted to: in the control group 12.9 ± 3.71 nmol/g; in the main group 10.2 ± 2.14 nmol/g, р = 0.1502.

Conclusion: Delivery of nitric oxide improved the parameters of energy supply of the renal tissue during cardiopulmonary bypass in the experiment.