bluuebunny/crossref_metadata_2025 huggingface dataset:
Next-generation sequencing on fine needle aspirates in neck recurrence of thyroid cancers
Authors: Théodon Hélène , Guillerm Erell , Wassermann Johanna , Deniziaut Gabrielle , Jaffrelot Loïc , Denis Jérome , Chereau Nathalie , Bigorgne Claude , Potonnier Wiame , Coulet Florence , Leenhardt Laurence , Buffet Camille
Published: January 2024

Objective

Tumor molecular genotyping plays a key role in improving the management of advanced thyroid cancers. Molecular tests are classically performed on formalin-fixed, paraffin-embedded (FFPE) carcinoma tissue. However alternative molecular testing strategies are needed when FFPE tumoral tissue is unavailable. The objective of our study was to retrospectively assess the performance of targeted DNA and RNA-based next-generation sequencing (NGS) on the fine needle aspirate from thyroid cancer cervical recurrences to determine if this strategy is efficient in clinical practice.

Design/Methods

A retrospective study of 33 patients who had had DNA and/or RNA-based NGS on ultrasound (US)-guided fine needle aspirates of cervical thyroid cancer recurrences in our Department from July 2019 to September 2022.

Results

In total, 34 DNA and 32 RNA-based NGS analyses were performed. Out of the 34 DNA-based NGS performed, 27 (79%) were conclusive allowing the identification of an oncogenic driver for 18 patients (53%). The most common mutation (n = 13) was BRAF c.1799T>A. Out of the 32 RNA-based NGS performed, 26 were interpretable (81%) and no gene fusion was found. The identification of a BRAFV600E mutation was decisive for one patient in our series, who was prescribed dabrafenib and trametinib.

Conclusion

NGS performed on fine needle aspirates of neck lymph node metastases enabled the identification of an oncogenic driver alteration in 53% of the cases in our series of advanced thyroid cancer patients and could significantly alter patient management.

Significance statement

This paper shows that thyroid cancer genotyping on the fine needle aspirate (FNA) of a metastatic neck lymph node recurrence can be performed efficiently. This strategy of genotyping appears particularly effective and safe when FFPE tissue is unavailable and when the spread of the disease requires systemic treatment. To the best of our knowledge, our data regarding DNA and RNA next generation sequencing on FNA of metastatic neck recurrences are the first ever published.
La responsabilidad penal de las personas jurídicas en Italia
Authors: Mongillo Vincenzo
Published: January 2024

El Decreto Legislativo n.º 231/2001 introdujo en Italia un modelo de responsabilidad “para-penal” (formalmente “administrativa”) de las entidades colectivas por la comisión de delitos que está resultando especialmente atractivo a nivel internacional, en buena parte porque fue pionero en la fundamentación de la responsabilidad penal/punitiva de la persona jurídica basada en el defecto de organización. El artículo analiza las características principales de la disciplina italiana, con el fin de señalar tanto sus puntos fuertes como sus problemas de aplicación y necesidades de reforma.
Pratuokng: The Borneo bamboo zither of Bidayuh Sarawak
Authors: Hamdan Sinin , Mohamad Said Khairul Anwar , Faudzi Musib Ahmad , Rahman Md Rezaur , Sawawi Marini , Sinin Aaliyawani Ezzerin
Published: January 2024

The pratuokng is an idiochord tube zither, which is a musical instrument. The Bidayuh Biatah pratuokng bamboo sound radiators of Annah Rais in Padawan, Sarawak, Malaysia are made up of seven strings and one drum. The sound reproduction capabilities are unique and innovative. This study intends to highlight the importance of sound studies in the studio setting. The frequency spectrum was evaluated using a Fast Fourier Transform (FFT) analysis via PicoScope oscilloscopes, and the time frequency analysis (TFA) using Adobe Audition that produced the spectrograms. The observations and perceptions offered by the actual meaning of this bamboo tube zither instruments showed that the notes of the pratuokng strings are E, D, F, Ab, B, A#, and B, respectively. The drum note is A. The 1st, 2nd, 3rd(A), 3rd(B), 4th(A), 4th(B), and 5th strings are 320 Hz (E4 = 329.63), 300 Hz (D4 = 293.67), 350 Hz (F4 = 349), 410 Hz (A4b = 415), 490 Hz (B4 = 493), 470 Hz (A4# = 466), and 500 Hz (B4 = 493), respectively, i.e., with note E, D, F, Ab, B, A#, and B, respectively. The drum is 210 Hz (A3 = 220). The signal in the frequency spectrum showed both distinct fundamental and higher partial frequencies. In particular, the first octave are present except for string 4B and 5. The inconsistent number of partials in each string is due to the inconsistent thickness of the raised fiber from the bamboo tube.
Caudillos en resistencia: Un estudio comparado de los jefes militares tras las montoneras realistas durante el proceso independentista. Los casos de Chile y el Perú (1819-1823)
Authors: Sáez Ledesma Héctor
Published: January 2024

El objetivo de este trabajo es identificar el rol de los caudillos realistas, basándonos en los casos de Chile y el Perú entre 1819 y 1824, período en que ambos países experimentaron guerrillas o montoneras, actuando simultáneamente bajo contextos similares dentro del proceso independentista del cono sur. Postulamos que, tras una posición de cercamiento, los caudillos realistas del cono sur, ejercieron un rol similar de resistencia como figuras articuladoras de diversos grupos populares, desde donde incitaban el desorden y sabotaje, diferenciándose de la figura del caudillo patriota como contenedor del orden social. Se ha recurrido al análisis de fuentes primarias, comparando las actuaciones en ambas unidades político geográficas, para identificar factores en común del periodo estudiado.
Élite política en la provincia de Lucanas, Ayacucho, durante el Oncenio de Leguía (1919-1930). El caso de los representantes parlamentarios
Authors: Tito Melgar Juan Leandro
Published: January 2024

El presente trabajo de investigación aborda el desenvolvimiento de los políticos locales de la provincia de Lucanas durante el segundo gobierno de Augusto B. Leguía (1919-1930). Se resalta la figura de los parlamentarios de Lucanas, ya que representaron un nexo entre la política local y la de carácter regional o nacional, tanto en el Parlamento Nacional como en el Congreso Regional del Centro, figura legislativa que solo existió en el Oncenio. Se evalúa su trayectoria, su relación con el régimen y finalmente su actividad posterior a este. Se concluye que los aportes realizados por estas autoridades fueron importantes en la búsqueda del progreso de la provincia. Para ello tuvieron que servir de nexo político entre el régimen autoritario y la población local por medio de relaciones clientelares.
Certain frequency music has attracted attention for possible effective healing
Authors: BANDO Hiroshi , Yoshioka Akiyo , Bando Masahiro , Nishikiori Yu
Published: January 2024

Music has various power for human body and mind. For 12 music tone, two types of scales are Pythagorean Tuning (just intonation) and equal temperament. This minute difference may generate human feeling for music. Music with 528Hz frequency has been in focus as healing music, which is called as “solfeggio frequency music”. Certain frequency music has been known such as 96, 432, 528, 639, 852 Hz, that contributes reducing tension and anxiety. It seems to show beneficial efficacy, but scientific evidence is not enough. Similar to former Mozart effect, further accumulation of evidence and research development will be expected.
Unmasking the challenges: misdiagnosis of extra pulmonary tuberculosis
Authors: Edward Majani , Mwinbong Alexandra D , Agyapong Daniel , Mahulu Eliton
Published: January 2024

Extra-pulmonary tuberculosis (EPTB) is a type of tuberculosis that occurs outside the lungs and can affect various body parts. Misdiagnosis of EPTB is a serious issue that can lead to delayed or incorrect treatment, resulting in serious complications and even death. The lack of awareness and training among healthcare professionals, inadequate diagnostic tools, and limited access to specialized tests are the primary reasons for misdiagnosis. Misdiagnosis can have severe consequences for patients with EPTB and contribute to the spread of TB. Increased awareness and training among healthcare professionals, the use of more sensitive diagnostic tools, and the development of new technologies are needed to improve the accuracy and speed of diagnosis. Timely and accurate diagnosis is crucial in preventing the spread of TB and reducing the burden of the disease on individuals and communities.
Assessment of health problem and associated factors among flower farm workers in Ejere Woreda, West Showa Zone Oromia Regional State, Ethiopia
Authors: Tadesse Melese , Kaso Mohammedawel , Bekele Diro
Published: January 2024

Background: Floriculture is an agricultural sector that poses significant health risks, often due to unsafe work environments. Objectives: The study aimed to assess health problems and associated factors among flower farm workers in Ejere Woreda, West Showa, Oromia, Ethiopia, in 2018. Methods: A cross-sectional study incorporating quantitative and qualitative methods was conducted in Ejere Woreda from May 25 to June 30, 2018. A structured questionnaire was administered to 356 participants using simple and stratified random sampling, and qualitative data were gathered through in-depth interviews and observation checklists. Data were analyzed using EPI Info version 7 and SPSS 21. Descriptive statistics were computed, and the variables underwent binary logistic regression analysis, with a p-value < 0.3 for inclusion in multivariate logistic regression. Thematic analysis was applied to qualitative data. Results: A total of 356 workers participated, with 296 (83.3%) reporting at least one health problem in the last 12 months. Among the conditions observed, headaches were the most prevalent (226, 76.4%), followed by musculoskeletal injuries (220, 74.3%), fatigue (206, 69.3%), respiratory injuries (185, 62.5%), dizziness (180, 60.8%), and skin injuries (17, 58.8%). Factors such as sex, job satisfaction, availability of personal protective equipment, and safety training showed significant associations with health problems. Conclusion: The study revealed a high prevalence of health problems among flower farm workers, with job satisfaction, availability of safety training, and personal protective equipment shortages being significant factors. It is recommended that farm managements provide adequate safety training and full personal protective equipment to improve the health of workers.
Ginkgo biloba: a medicinal plant with clear effects and many indications
Authors: Doepp Manfred
Published: January 2024

There are not many herbal remedies that are as well known worldwide as the extract from the leaves of the Ginkgo biloba tree. This remedy has not only been used as a folk remedy in East Asia for thousands of years, but its effectiveness has also been proven in all recent studies. The emphasis is on improvements in blood circulation with blood thinning and improvements in brain performance. It therefore meets a large number of current needs in outpatient therapy, especially for older people. It is postulated that the drug (EGb 761®) should generally be used in older people.
TREATMENT OF COMPLICATED DEEP SOFT TISSUE INFECTIONS BY A COMBINATION OF NEGATIVE PRESSURE WOUND THERAPY AND INTRALESIONAL TOPICAL APPLICATION WITH STABLE OZONIDES OZOILE® FIRST CASES IN BULGARIA
Authors: Marinova P.
Published: January 2024

Introduction. Severe necrotizing soft tissue infections (SNSTI) are life-threatening conditions that require timely diagnosis and immediate surgical treatment. As part of the comprehensive treatment of severe fasciitis, the application of a new method of treatment, combined permanent negative pressure wound therapy (NPWT) and Ozoile ®, stable ozonides from organic extra- virgin olive oil +OIL®, may be considered.
The aim is a retrospective analysis of patients with severe soft tissue infections treated at the First Surgical Clinic of UMHAT "Dr. G. Stranski" LtD - Pleven with NPWT negative pressure and topical applications of Ozoile ®, stable ozonides from organic extra- virgin olive oil +OIL® and to compare the final results and outcome with group patients treated by conventional methods and NPWT alone.
Materials and methods. A retrospective, randomized study over 1 year (March 2022- March 2023), including 84 patients with SNSTI treated surgically with NPWT and local ozone therapy; 35 with NPWT and 170 by fasciotomy, wound debridement, and wound lavages.
Results. A total of 232 patients with SNSTI were divided into three subgroups according to treatment strategy. NPWT with local ozone therapy has a significantly shorter hospital stay (p<0,05), time to sterilization (p<0,05), and faster epithelization rate (p<0,05), compared with the conventional treatment strategy. Conclusion The NPWT combines with topica application of Ozoile® and stable ozonides is a novel and effective method for the treatment of SNSTI.
TRANSCRIPTION FACTORS IN CEREBELLAR DEVELOPMENT
Authors: Velikov I.
Published: January 2024

The cerebellar germ arises from the rhombic lip, and it’s a rostral part from the mesencephalon. The following cellular processes take place in the developing cerebellum: proliferation, migration, differentiation, synapse formation and cell death. An important step is the transformation of the Purkinje cell layer from a multilayer composition into a monolayer. This structural reorganization is followed by the foliation process. At first, the smooth surface is divided into five major lobes by four grooves in the vermis. In the next phase major lobes are subdivided into sublobes and lobules and they grow in size. The development of granular neurons in the cerebellum takes place in two phases. The first is in the rhombic lip and the second is in the external granular layer (EGL). The development is directed by some transcription factors such as sonic hedgehog (Shh), Zbtb, and Pax6.
First record of Anolis sagrei Dumeril & Bibron, 1837 (Squamata, Anolidae) in Sonora, northwestern Mexico
Authors: Pérez-Delgadillo Ana Gisel , Lara-Reséndiz Rafael A.
Published: January 2024

Anolis sagrei is a lizard that naturally occurs on various islands of the Caribbean and in Central America. However, it has also been widely introduced in different countries around the world. In Mexico, it is present in seven states with tropical climate Here, we present the first record of A. sagrei from the Mexican state of Sonora.
Investigating The Influence of Conformity and Fanaticism on Bullying Dynamics
Authors: Mulyana Agus , Supenawinata Anwar , Kurnia Muhamad Fasha
Published: January 2024

Bullying is a pervasive social issue within the Indonesian context, manifesting in various situations, including sports, where the behavior can occur between fellow athletes and supporters at a sporting event. Therefore, this research aimed to investigate the influence of conformity and fanaticism on incidents of bullying among supporters of the Persib Bandung football team. A quantitative causality approach was used, with data analysis executed through multiple regression to obtain 349 respondents. The results showed that conformity and fanaticism influenced bullying by Persib Bandung supporters. Specifically, the combined influence of the variables accounted for 3.3% of the observed incidents. Conformity had a partial influence of 15.8% on bullying ,while fanaticism did not show any statistically significant influence.
Are Practices Self-Governing?
Authors: Pocock Jeffrey
Published: January 2024

In this paper I consider the question of self-governing in relation to MacIntyrean practices. It is not uncommon to discover MacIntyrean practices being described as self-governing in at least some sense. However, while there are seemingly valid reasons for why this might be thought the case, in my paper I argue that there is something very different visible in MacIntyre’s writings here. Indeed, what I want to emphasise regarding MacIntyre’s position in relation to the governing of practices is that rather than self-governing, at most MacIntyrean practices are self-directing or self-guiding. Therefore, although for MacIntyre governing of practices is fundamentally important, what I draw attention to is how, on the whole, this governing happens from outside, and that direction and guidance if and when it does happen, happens in a very specific, internal way aside from governing.
Optimization of mimetic periosteum autografts for the treatment of nonunions
Authors:   , Juan Antonio Romero
Published: January 2024

Bone presents truly regenerative capacity being able to regenerate into a native state in response to injuries. Despite this self-renewal potential, bone healing is not absent of complications and different conditions can interfere with the regenerative process, leading to delayed fracture and in some cases fracture nonunion. Fracture nonunion is a major cause of chronic pain and disability and, despite the low incidence of nonunion and delayed union fractures (5-10%), the numerous fractures that take place globally (~180 million every year) emphasizes the huge economic burden that fracture nonunion represents. Once detected, fracture nonunion requires a surgical approach, and the use of bone autografts that provide and osteoinductive, osteogenic and osteoconductive environment for a successful repair. However, the availability of bone grafts is limited. The scarcity of bone tissue that can be used for autografts have consolidated the need for novel tissue engineering approaches as potential candidates for the treatment of nonunion and for long bone defects, prone to evolve to nonunions. Tissue engineering strategies allow for the combination of novel tunable materials along with different biological adjuvants, including growth factors and cells. During the bone regenerative response, the periosteum, a fibrous layer surrounding the bone, plays a key role delivering osteochondroprogenitor cells and crucial growth factors into the injured tissue. Thus, we developed a tissue engineering strategy where biocompatible, 3D melt-electro-written polycaprolactone membrane would act as a mimetic periosteum. The engineered mimetic periosteum allows vascularization of the construct either when implanted ectopically or orthotopically. Additionally, we demonstrated its capacity to be functionalized with rhBMP-2, the most important morphogen for bone regeneration, both exposed on the membrane surface attached through PEA-hFN or encapsulated in microparticles covalently bound to the PCL membrane. When functionalized with low doses of rhBMP-2 the mimetic periosteum demonstrated great osteogenic potential in vitro, inducing human MSCs differentiation into osteoblasts. More importantly, in vivo results indicate that the functionalization of the mimetic periosteum with rhBMP-2 allows regenerative properties able to heal critical size femoral defects in SD rats with high efficiency and reproducibility using unpreceded low doses of rhBMP-2. Ultimately, the mimetic periosteum demonstrated its ability to deliver key mesenchymal progenitor cells into the injured site. All these results indicate that our engineered mimetic periosteum represents an efficient system for rhBMP-2 and progenitor cells delivery with important translational potential.
Briefing: An examination of social legacy using a long-term perspective
Authors: Ward Kate
Published: January 2024

The social legacy of infrastructure is a complex concept that is not clearly understood. It can incorporate social value practices, as defined in legislation, but must also consider the intrinsic benefits of infrastructure, that is the services that infrastructure provides to allow communities to flourish and, crucially, how long that impact will last. Examination of the impact of infrastructure systems – in this case sewers – reveals that engineering solutions can over time become burdens on society that are expensive to maintain and difficult to transition away from, restricting the ability to seek better approaches. The key lesson is that the legacy of our infrastructure may be to constrain the choices open to future generations by locking them in to a path we have defined. The conclusion is that the social legacy that engineers should consider is how to avoid burdening future generations, leaving them free to seek solutions that best suit the circumstances of their time.
Volodymyr Pilat – the creator and leader of the Fighting Hopak style. Contribution to the modern history of Ukrainian martial arts
Authors: Cynarski Wojciech J.
Published: January 2024

Many nations today promote their historical martial arts and combat sports. This may result from the need to emphasize their own national traditions and cultural heritage. Thanks to outstanding figures, enthusiasts and people with a sense of mission, traditions that are partly lost are being created or restored. An example is Grand Master Volodymyr Pilat – the creator of the system called Boiovyi hopak (Battle / Combat hopak). The author, based on a direct interview and available publications, presents his path to the creation of this martial art, which is also a combat sport, and the establishment of an international federation, which indicates an already advanced institutional development. An analysis of sources was also used, including film materials and photos (visual anthropology). The specificity of this fighting art is shown, which is strongly related to the experiences of of Master Pilat’s “way of the warrior”. Boiovyi hopak was created on the basis of Cossack traditions and the experience of Volodymyr Pilat’s “way of the warrior”. The historical hopak was a dance. It is often practised with music. Among the traditional weapons there are a long stick, sabre, pike, scythe, sickle, mace, flail and ice axe.
The Influence of the Integrated Education Program on the Psycho-Physical Readiness of Children for School Education
Authors: Panhelova Nataliia , Panhelova Mariia , Pyvovar Andriy , Ruban Vladislav , Kravchenko Tetiana , Chuprun Nataliia
Published: January 2024

Modernization of preschool physical education is the subject of research by many scientists. The development and introduction of innovative recreation and health technologies into the practice of physical education in preschool education institutions is necessary in connection with the intensification of the educational load in the process of systematic preschool education, which increases the static component and negatively affects the physical condition of children and their readiness to school education. The implementation of existing physical culture and health technologies into the practice of physical education is slow. The purpose of the study is to implement and determine the impact of the comprehensive personality development program on the level of development of physical, cognitive abilities and speech of older preschoolers. Theoretical analysis and generalization of scientific and methodical literature, pedagogical, medical and biological methods, psychodiagnostic methods, methods of mathematical statistics were used in the study. Improvement of the content of physical culture and health work with older preschoolers in establishments of preschool education took place by introducing: innovative technologies of physical education, methods of psycho-prophylactic work, elements of tourist and local history activities, elements of sports-oriented physical education. These approaches were implemented through four blocks of physical exercise classes: physical education classes, physical culture andhealth activities during the day, active recreation, tourist and local history activities. Based on the determination of the means of combined development of motor and mental qualities, program material for the complex development of physical and cognitive abilities of older preschoolers in the process of physical education was developed.
Justice, Science and Sociology of Economic Systems: Transformation of Revelation into Dogma
Authors: Zimina Ekaterina , Khaustov Dmitry
Published: January 2024

The subject of the study is the transformation of the concept of justice. The object of the study is to identify the content of the concept of «Justice» depending on the cultural and historical context. The authors consider in detail several interrelated parts of humanitarian research with special emphasis on the transformation of thinking patterns: virtue and justice Post-Newtonian transformation of science; Prophet and teacher: from revelation to dogma; Insight, conversion and the sociology of non-capitalism. The article examines and compares the changes that have occurred in the ideas of justice, economic development, and science. Special attention is paid to the analysis of the problem of the correlation of «moral luck» and «moral catastrophe» as components of the very concept of justice. The novelty of the research lies in the hypothesis put forward by the authors, which consists in the fact that the transformations that happened to the ideas of social justice in some way correspond to the transformation of the European sciences created by the Royal Society of London during the time of Isaac Newton and Robert Hooke. The main conclusion was that there is one difficulty in actualizing the object of theoretical research — the presence of «invisible» transformations of the idea of Justice that involves implicit retrospection and «tipping into the past» of current ideas about morality and justice.
ТРАДИЦИИ И НОВАЦИИ В ФИЛОСОФСКОМ ОСМЫСЛЕНИИ ИДЕОЛОГИИ
Authors: Трунов Анатолий Анатольевич , Дагаев Рашид Рамазанович
Published: January 2024

Цель исследования заключается в том, чтобы осуществить сравнительный анализ основных парадигм философского исследования идеологии в обществах модерного и постмодерного типов.

Методологическую базу исследования представляют принципы системности и историзма, ведущие философские подходы к осмыслению идеологии в их классических, неклассических и постклассических интерпретациях, морфологический анализ, структурный психоанализ, постструктурализм, герменевтика, культурологический и философско-антропологический подходы.

Результаты исследований. В статье реконструированы классические, неклассические и постнеклассические подходы к изучению идеологии в обществах модерного и постмодерного типов. Особое внимание уделено характеристике морфологического анализа идеологий, а также выявлению специфики функционирования диффузной идеологии в условиях цифровизации, виртуализации и сетевизации общества.

Перспективы исследования обусловлены необходимостью глубокого и всестороннего изучения влияния диффузной идеологии на сознание, эмоции и поведение своих реципиентов в условиях цифровизации, виртуализации и сетевизации современного общества
ЦИФРОВЫЕ ТЕХНОЛОГИИ И БЮРОКРАТИЧЕСКИЕ ПРАКТИКИ В СИСТЕМЕ ВЫСШЕГО ОБРАЗОВАНИЯ
Authors: Павлов Павел Викторович
Published: January 2024

Целью статьи является анализ современных бюрократических практик в контексте развития цифровых технологий. Особое внимание уделяется проблеме цифровых технологий и бюрократии в сфере высшего образования.

Методология исследования. Статья базируется на теоретико-методологических подходах к исследованию современной бюрократии, цифровых технологий и системы высшего образования. В методологическом плане определяющими выступили идеи Дэвида Гребера о «тотальной бюрократизации» современного общества.

Результаты исследования. Специфика современных бюрократических практик и их взаимосвязь с новыми цифровыми технологиями определяются логикой развития капитализма. В статье сделан акцент на изучении особенностей реализации этих практик в современной системе высшего образования.
АКАДЕМИЧЕСКОЕ ЛИДЕРСТВО В КОНТЕКСТЕ ИНТЕЛЛЕКТУАЛЬНОГО РАЗВИТИЯ МОЛОДЕЖИ
Authors: Черных Сергей Сергеевич
Published: January 2024

Основная цель статьи заключается в анализе академического лидерства в качестве важного и дискуссионного концепта высшего образования. Данное понятие рассматривается сквозь призму интеллектуального развития молодежи, социализация которой происходит в условиях экспансии цифровых технологий. Выявлена проблема оценки качества образования в контексте противоречий между преподавательским корпусом и академической бюрократией.

Методология исследования. Статья базируется на современных подходах оценки качества образования, происходящего в условиях цифровизации. В методологическом плане наиболее важными стали проблемы, получившие освещение в творчестве отечественных философов и социологов, таких как Г. С. Батищев, Ф. И. Гиренок, Ю. А. Зубок, Г. Л. Тульчинский, и др. исследователей.

Результаты исследования. В статье показано, что современное образование в значительной степени коммерциализируется, все больше напоминая корпорацию, в которой тон задают не профессора, имеющие реальный опыт преподавания дисциплин, а представители класса академических менеджеров. Оценка качества образования в большей степени ориентируется на количественные показатели, различного рода рейтинги, тогда как в молодежной среде утверждается «клиповое сознание» и вполне определенный тип креативности, не соответствующий классическим стандартам творчества.

Перспективы исследования. Проделанная работа открывает дальнейшие перспективы изучения широкого спектра проблем образования и интеллектуального развития молодежи на основе уже достигнутого опыта обучения и творчества.
Perancangan audio streaming menggunakan wifi berbasis mikrokontroler atmega 328
Authors: Annas Muhammad Satya , Maulana Dimas
Published: January 2024

Perkembangan teknologi elektronika digital saat ini mengarah pada semakin mengecilnya perangkat keras dengan kemampuan komputasi yang kuat. Begitu juga dengan perangkat audio streaming yang selama ini membutuhkan server PC, telah memungkinkan untuk digantikan dengan mikrokontroler. Tujuan dari penelitian ini adalah untuk menciptakan sistem yang dapat menyiarkan sinyal audio melalui Wi-Fi dari komputer ke set speaker. Dari sejumlah pilihan yang ada, didapatPerkembangan teknologi elektronika digital saat ini mengarah pada semakin mengecilnya perangkat keras dengan kemampuan komputasi yang kuat. Begitu juga dengan perangkat audio streaming yang selama ini membutuhkan server PC, telah memungkinkan untuk digantikan dengan mikrokontroler. Tujuan dari penelitian ini adalah untuk menciptakan sistem yang dapat menyiarkan sinyal audio melalui Wi-Fi dari komputer ke set speaker. Dari sejumlah pilihan yang ada, didapatkan bahwa protokol Wi-Fi paling memungkinkan digunakan sebagai metode komunikasi karena perangkat Wi-Fi telah dipasang pada semua laptop modern. Sistem ini memungkinkan pengguna untuk memutar file audio dari komputer ke speaker dalam jangkauan jaringan nirkabel. Dalam penelitian ini bertujuan memanfaatkan penggabungan penggunaan perangkat keras, pemrograman perangkat lunak tingkat rendah, dan protokol standar IEEE 802.11 untuk komunikasi nirkabel (Wi- Fi). Pada penelitian ini digunakan pengkodean data audio oleh encoder sesuai dengan spesifikasi format file WAV.  Hasilnya didapatkan bahwa mikrokontroler ATMega328 mampu mengirimkan audio streaming 2 kanal 8 bit dengan sistem yang telah direncanakan.kan bahwa protokol Wi-Fi paling memungkinkan digunakan sebagai metode komunikasi karena perangkat Wi-Fi telah dipasang pada semua laptop modern. Sistem ini memungkinkan pengguna untuk memutar file audio dari komputer ke speaker dalam jangkauan jaringan nirkabel. Dalam penelitian ini memanfaatkan penggabungan penggunaan perangkat keras, pemrograman perangkat lunak tingkat rendah, dan protokol standar IEEE 802.11 untuk komunikasi nirkabel (Wi- Fi). Pada penelitian ini digunakan pengkodean data audio oleh encoder sesuai dengan spesifikasi format file WAV.  Hasilnya didapatkan bahwa mikrokontroler ATMega328 mampu mengirimkan audio streaming 2 kanal 8 bit dengan sistem yang telah direncanakan.
Penerapan teknik scraping python pada website marketplace indonesia
Authors: Sembiring Falentino , Sari Dian Permata
Published: January 2024

Marketplace adalah sebuah website atau aplikasi online yang memfasilitasi proses jual beli dari berbagai toko, online marketplace memiliki konsep yang kurang lebih sama dengan pasar tradisional. Terkadang setiap situs e-commerce menawarkan produk dengan diskon yang sangat besar. Persoalannya, banyak sekali konsumen yang tertipu dengan “iming-iming” diskon, sedangkan harga yang dijual sebenarnya sudah dinaikkan terlebih dulu sebelum didiskon sehingga harga yang terjual terkesan murah namun sebenarnya mahal. Pada penelitian ini peneliti bertujuan untuk mengetahui penerapan teknik scraping python pada website marketplace di Indonesia dan mengolahnya menjadi sebuah website perbandingan harga yang ditawarkan kepada konsumen. Model pengembangaan sistem yang digunakan adalah System Development Life Sycle (SDLC) yang merujuk kepada teori SDLC Raymond Mcleod tahun 2007 memuat beberapa hal, yaitu:  analisis, desain, testing dan implementasi. Hasil dari penelitian ini berupa website perbandingan harga antar marketplace Bukalapak dan Shopee dengan mengambil data produk pada kategori handphone dan sepatu pada marketplace Bukalapak dan Shopee menggunakan bahasa pemrograman Python.
Peranan prinsip kepuasan pelanggan guna meningkatkan jumlah penjualan pada ecommerce
Authors: Akbar Robby , Almuyassar Muhammad Hilmy , Fidi Satria Putra
Published: January 2024

Kepuasan pelanggan merupakan penilaian yang diberikan konsumen terhadap kualitas produk ataupun jasa dari sebuah perusahaan. Kepuasan didapatkan karena keinginan dan kebutuhan pelanggan yang terpenuhi atau sesuai dengan ekspektasi atau melebihi yang diharapkan. Dengan penilaian kepuasan yang diberikan konsumen pada suatu ecommerce penjual mengharapkan adanya peningkatan jumlah transaksi pada toko mereka. Namun, untuk mengetahui benar atau tidaknya kepuasan pelanggan pada suatu produk di e-commerce tidak hanya bisa dilihat dari ulasan yang diberikan saat order telah selesai. Tujuan dari penelitian ini adalah untuk mengetahui variabel/prinsip kepuasan pelanggan apa saja yang bisa meningkatkan jumlah penjualan pada suatu ecommerce. Dengan melakukan kajian literatur terhadap teori-teori dari kepuasan pelanggan dan juga faktor yang mempengaruhinya. Dari hasil kajian diperoleh bahwa yang dapat meningkatkan penjualan berdasarkan kepuasan pelanggan adalah kualitas produk dan kualitas layanan yang diberikan dari toko meliputi kinerja, ketersediaan, daya tahan, estetika, keandalan, pemeliharaan, logistik, dukungan, layanan pelanggan, pelatihan, pengiriman, penagihan, perbaikan, pemasaran, garansi, dan biaya siklus hidup. Diharapkan prinsip-prinsip tersebut dapat diimplementasikan oleh pelaku usaha di toko pada  ecommerce yang mereka gunakan.
Infrastruktur cloud pintar dalam sistem layanan informasi berbasis big data
Authors: Aditya Ristian
Published: January 2024

Penelitian ini mengulas konsep dan implementasi infrastruktur cloud pintar dalam sistem layanan informasi berbasis big data. Infrastruktur cloud telah menjadi elemen kunci dalam menunjang penyimpanan dan pemrosesan data skala besar. Namun, dengan kemajuan teknologi dan kebutuhan yang semakin kompleks dalam domain big data, diperlukan pendekatan yang lebih cerdas untuk mengelola sumber daya cloud. Dalam penelitian ini, mendiskusikan bagaimana infrastruktur cloud pintar mengintegrasikan elemen-elemen seperti komputasi awan yang adaptif, manajemen data yang dinamis, dan kecerdasan buatan (AI) untuk mengoptimalkan kinerja sistem layanan informasi berbasis big data. Penjelasan manfaat potensial dari infrastruktur cloud pintar, termasuk peningkatan efisiensi, skalabilitas, dan kemampuan untuk mengatasi tantangan kompleks yang terkait dengan data besar. Penelitian ini bertujuan membawa pandangan yang mendalam tentang perkembangan terbaru dalam teknologi cloud dan bagaimana infrastruktur cloud pintar mendorong evolusi sistem layanan informasi di era big data. Dengan menggabungkan fleksibilitas cloud dengan kecerdasan buatan, penelitian ini mewakili upaya untuk menciptakan solusi yang lebih adaptif dan efisien dalam mengelola dan memanfaatkan data besar untuk berbagai tujuan informasi.
Pengembangan website pariwisata budaya sebagai platform wisata digital di masa pandemi
Authors: Agusta Rizky Merdika , Hardiwijaya Dimas Firdlous , Nursolihah Firda Rahayu , Aisah Aisah
Published: January 2024

Berbagai sektor terkena pengaruh dari pandemi. Salah satunya adalah sektor pariwisata. Sektor pariwisata di masa pandemi menjadi salah satu kebutuhan masyarakat yang terganggu pengembangannya. Masyarakat yang dihimbau untuk tidak keluar rumah dan melakukan kontak fisik dengan orang banyak, menjadi hambatan dalam berkegiatan pun salah satunya berwisata. Hal tersebut berdampak besar bagi sektor pariwisata serta wisatawan itu sendiri. Padahal sektor pariwisata masih sangat diminati masyarakat di masa pandemi. Maka dari itu, tim pengembang berusaha mengembangkan sebuah platform wisata yang menggunakan manfaat teknologi. Wisata digital sebagai upaya yang dianggap bisa menjadi solusi dari permasalahan diatas pun dikembangkan. Tim pengembang menggunakan platform website sebagai platform yang dianggap tepat untuk pengembangan platform wisata digital ini. Sehingga diharapkan dengan adanya platform wisata digital ini masyarakat, wisatawan dan sektor pariwisata tetap dapat berjalan tanpa hambatan-hambatan di masa pandemi. Wisatawan dapat melepaskan kejenuhannya dan pelaku bisnis pariwisata pun mendapatkan dorongan agar dapat kembali produktif seperti sedia kala.
Rancang bangun jaringan hotspot warung wifi (wawi) dengan metode design thinking
Authors: Imam Chaerul , Sudaryat Muhamad Ridwan , Casapisa Pakhri Algipari , Zaki Muhammad Raihan , Fadholli Moch Ubaidillah
Published: January 2024

Internet sudah menjadi kebutuhan pokok masyarakat semua  kalangan, begitu juga bagi masyarakat yang berada di pedesaan yang  notabene dikelilingi oleh pegunungan. Kebutuhan terhadap akses  internet di pedesaan banyak keterbatasaan belum se-mudah, se-murah dan se-lancar seperti di perkotaan, bahkan masyarakat perlu  usaha yang lebih seperti naik ke genteng, bukit dan tempat  tinggi lainnya untuk mendapatkan signal yang relatif lebih stabil.  Penelitian ini menggunakan metode pengembangan design thinking. Tujuan Penelitian ini untuk merancang jaringan hotspot warung  wifi (wawi) berbasis mikrotik sebagai solusi layanan akses internet  yang mudah, murah dan lancar layaknya di perkotaan. Dengan  konsep jaringan hotspot warung wifi masyarakat dapat merasakan  internet eceran berupa hotspot voucher dengan harga yang relatif  terjangkau dan lebih murah dibanding menggunakan kartu GSM  atau CDMA, keuntungan yang lain berupa peningkatan ekonomi bagi  Warung yang ikut menjadi partner penjualan dari voucher hotspot.  Hasil dari penelitian ini berupa ide, serta rancangan prototype dengan  alur empathize, define ideation, prototyping dan testing untuk  mengetahui kebutuhan pengguna dengan baik.
Pembuatan content management system sebagai upaya percepatan penurunan stunting di kota bandung
Authors: Hakim Lukman , Elsen Rickard
Published: January 2024

Stunting bukan masalah yang bisa di anggap sebelah mata karena pertumbuhan yang tidak sesuai pada anak balita juga berpengaruh pada kemampuan kinerja otaknya. Pemerintah Kota Bandung melakukan gerakan percepatan penurunan stunting di Kota Bandung dengan membuat aplikasi e-Penting.Dinas Komunikasi dan Informatika Kota Bandung merupakan unsur utama dalam bidang teknologi yang mengembangkan from input stunting. Pembuatan aplikasi ini membutuhkan banyak pihak yang terkait karena dibutuhkan data yang akurat dan cepat. Karena perlu mengumpulkan data dari banyak pihak terkait seperti Dinas Kesehatan, Dinas Kesejahteraan Rakyat, Dinas Sosial, dll maka aplikasi e-Penting ini perlu didukung sistem informasi penginputan data stunting untuk mengumpulkan data dari pihak terkait secara berkala yang lebih efisien dan efektif sehingga data yang terkumpul bisa langsung ditampilkan pada aplikasi e-Penting. Selain itu data yang disajikan dari setiap kedinasan masih dalam bentuk Microsoft excel yang dinilai masih kurang efektif. Tujuan dari penelitian ini adalah untuk mengembangkan suatu aplikasi sistem informasi penginputan data dari setiap kedinasan agar bisa menginput, menghapus, dan tersimpan secara otomatis di database dari aplikasi e-Penting menggunakan metode Prototype dengan framework laravel. Aplikasi e-Penting nantinya akan menyajikan informasi yang akurat karena sudah terintegrasi dengan aplikasi Form Input Stunting. Hasil dari penelitian ini adalah berupa website form input stunting dan semua fungsi berjalan sesuai dengan kemauan pengguna.
Implementasi frontend web dinamis untuk aplikasi podcast player
Authors: Amhar Rasyad , Syaifunazhirin Fakhris
Published: January 2024

Podcast saat ini menjadi salah satu media konten yang sangat populer di kalangan pengguna internet. Kelebihan podcast terletak pada fleksibilitas dan intensitas pengalaman yang ditawarkannya dibandingkan dengan media konten lainnya. Podcast memberikan kebebasan kepada pendengarnya untuk mendengarkan konten audio sesuai dengan keinginan mereka, kapan pun mereka inginkan. Hal ini berbeda dengan siaran radio yang memiliki keterbatasan dalam hal akses, frekuensi, dan waktu.. Maka dari itu, diperlukan solusi dengan membuat aplikasi yang bisa memutar podcast dengan akses yang fleksibel dimanapun individu berada. Dengan implementasi menggunakan HTML, CSS, Javascript dan Library Jquery dari design aplikasi untuk pemutar podcast bernama “SOUNDS” yang sudah ada, menjadi sebuah tampilan web yang dinamis sehingga user tanpa perlu menunggu waktu dan tempat yang cocok untuk memutar podcast kesayangan mereka. Dengan adanya aplikasi "SOUNDS" ini, diharapkan pengguna internet dapat lebih menikmati podcast favorit mereka dengan cara yang lebih fleksibel dan mudah diakses. Pengembangan aplikasi ini akan memberikan pengalaman yang lebih memuaskan dalam menikmati konten audio melalui podcast, serta membuka peluang untuk pengembangan fitur-fitur tambahan yang dapat meningkatkan pengalaman pengguna secara keseluruhan.
Analisis pemanfaatan aplikasi internal arsip terhadap efektivitas pengelolaan arsip statis
Authors: Syafila Zamnna Gea , Fauzi Esa , Hidayat Muhammad , Haryanto Deni
Published: January 2024

Penelitian ini bertujuan untuk mengetahui pemanfaatan aplikasi internal arsip dalam mendukung efektivitas pengelolaan arsip statis di lingkungan Dinas Arsip dan Perpustakaan Purwakarta, serta mengevaluasi kekurangan dalam aplikasi tersebut yang dapat mengurangi efektivitas pengelolaan Arsip. Metode penelitian yang digunakan dalam penelitian ini merupakan metode penelitian deskriptif dengan pendekatan kualitatif studi kasus. Teknik pengumpulan data yang dilakukan adalah observasi, wawancara, dan studi dokumentasi yang dilaksanakan di Jl Veteran, No. 01, Komplek Perum Griya Asri, Ciseureuh, Purwakarta. Hasil penelitian menunjukkan bahwa penggunaan aplikasi internal arsip secara signifikan meningkatkan efektivitas pengelolaan arsip dibandingkan dengan metode konvensional. Aplikasi berbasis web ini memberikan dukungan yang baik dalam hal pencarian dan penyimpanan informasi dokumen. Namun, penelitian ini juga mengidentifikasi beberapa kekurangan dalam aplikasi tersebut yang dapat mengurangi efektivitas pengelolaan arsip. Kekurangan tersebut harus segera diatasi agar aplikasi dapat memberikan manfaat maksimal dalam pengelolaan arsip statis.
Data-Driven Design Optimization for Metal Additive Manufacturing
Authors:   , Perumal Vignesh Inbashekhar , Kontsos Antonios , Najafi Ahmad Raeisi
Published: January 2024

Metal Additive Manufacturing (AM) has become a viable method of fabricating complex geometries that are difficult and even impossible to manufacture using some of the traditional techniques. Design for Additive Manufacturing (DfAM) approaches leverages the vast potential of AM approaches for getting optimal and novel part designs. However, the inherent cyclic thermal nature of metal AM processes creates thermal gradients in the printed part resulting in geometry challenges such as residual stress induced distortions which compromise the overall part performance. Therefore, the reliability and performance qualification of metal AM parts is critical for their safe and successful adoption in engineering applications. The thermal profile in metal AM parts is dependent on the process parameters used for printing, the geometry of the part, and the orientation used while printing. For these reasons, a 3D-printed part optimized using standard design optimization formulations that do not account for these manufacturing parameters may not provide the desired part performance. The work presented in this dissertation proposes a potential approach that may help address this critical issue. Design considerations for AM rely on thermomechanical process simulations; which although provide valuable insights on the role of manufacturing parameters and overall geometry on the print quality, do not offer direct ways to adapt the target part geometry into the specific AM process used and thus create a disconnect between the model and the produced part. To address this issue, this dissertation presents an approach to directly couple In-Situ Monitoring (ISM) data of the AM process with a gradient-based topology optimization approach. To accomplish this goal, a database of thermal data is generated by printing candidate parts for which in-situ monitoring data is collected. Neural network-based surrogate models are then used to predict temperature and temperature gradients for novel part geometries. A bi-objective topology optimization with mechanical and thermal constraints that queries the surrogate model for the thermal data and runs a static structural finite element solver for the mechanical objective evaluation is used. The proposed data-driven approach is much faster than current trial-and-error DfAM approaches. This approach is also expected to provide more optimal design outcomes than by previous DfAM approaches proposed in literature.
Dielectrophoretic Characterization of Macrophages and Low-cost Cell Separating DEP Wand
Authors:   , Soe Mi Thant Mon , Soe Mi Thant Mon , Noh Moses
Published: January 2024

Dielectrophoresis (DEP) is a label-free cell separation method that distinguishes cells based on their relative polarizability to the surrounding medium in non-uniform electric fields. Even though it can rapidly detect cellular changes undetectable by popular labeling based cell separation techniques, DEP cell separation devices are not used by biomedical researchers. This is due to the complexity, low throughput and clogging issues associated with microchannels and high fabrication costs of DEP devices that are comparable to current methods like fluorescence-activated cell sorting (FACS). This thesis focuses on strategies to get biomedical researchers to consider using DEP cell separation: (1) characterizing the sensitivity of DEP to detect changes in cell phenotype after a chemical stimulus, and (2) developing a low-cost DEP separation device without microchannels. Macrophage phenotypes such as pro-inflammatory (M1) persists in chronic ulcers, while pro-healing (M2) phenotypes linked to tumor prognosis, were chemically induced from non-activated (M0) macrophages. Characterizing the differences in their DEP response and membrane capacitance show how they could be leveraged to advance the development of devices for disease diagnostics, and rapid detection and separation of macrophages to advance novel therapeutic strategies in cancer and chronic wound healing. Furthermore, to enable biomedical researchers to easily and cost effectively separate cells, a handheld cell separating DEP wand device (DEP PenCell) compatible with cell culture plates was fabricated using commercially available wires and negative anisotropic thermal expanding material. DEP PenCell performance was characterized using model live and dead yeast cells. The influence of parameters such as frequency of the AC signal, collection time and wash steps on the number and viability of separated cells were evaluated. Thus, DEP cell separation devices could be more viable to biomedical researchers.