bluuebunny/crossref_metadata_2025 huggingface dataset:
RELIGIÃO E CULTURA PERIFÉRICAS: A REPRESENTAÇÃO DO ISLAMISMO NA CLASSIFICAÇÃO DECIMAL DE DEWEY
Authors: Miranda Marcos Luiz Cavalcanti de , Silva Fabio Gomes da
Published: March 2019

Analisa a representação de informações referentes à identidade e a religião islâmica no esquema de classificação bibli-ográfica mais utilizado do mundo. Investiga a existência de desvios na representação de assuntos referentes a culturas não alinhadas à cultura ocidental na 23ª edição da Classificação Decimal de Dewey (CDD23). Conceitua Organização do Conhecimento em sentido restrito como organização das informações em registros bibliográficos e, em sentido amplo, como a organização social do trabalho mental. Define Sistemas de Organização do Conhecimento, enquanto sistemas conceituais atuantes como tipos de representação do conhecimento sendo frutos da organização do conhe-cimento. Aborda a construção do conceito de Islamismo no Ocidente considerando as transformações de sentido mo-duladas pelo contexto sociocultural, conferindo ao Islã a imagem da violência. Define Religião segundo Durkheim como sistema unificado de crenças e de práticas relativo a coisas sagradas; e segundo Hans Mol como a identidade sacralizada. Aponta que a parcialidade na organização do conhecimento permite que documentos relativos à cultura e à identidade de grupos sociais não alinhados jamais sejam recuperados. Objetiva identificar como os assuntos referen-tes a culturas não alinhadas com o ocidente estão organizados; verificar a influência do contexto sociocultural na representação e recuperação da informação em bases de dados de culturas diversas; analisar o Islamismo e suas rela-ções conceituais na CDD. Para alcançar os objetivos propostos realizamos estudosna CDD23 segundo a metodologia de Miranda (2009), pesquisa bibliografica em bases de dados de diferentes culturas com ênfase nas influências do contexto sociocultural na produção cientifica pertinente a cultura Islâmica. Os resultados do estudo da representação do Islamismo na CDD23 demonstaram a existência de desvios (biases) de representação históricas da CDD, evidenci-ados tanto na seleção terminológica quanto em sua estrutura conceitual. Os resultados do levantamento bibliográfico nas bases de dados demonstram uma produção cientifica sobre assuntos referentes a cultura e identidade muçulmana numerosa e diversificada nas bases de dados de natureza global (DOAJ) e não ocidental (AJOL) e uma baixa produção na base de dados ocidental (Scielo). Reitera a necessidade da conduta ética por parte do profissional na classificação de assuntos não alinhadas a cultura ocidental.
Clinical Pharmacokinetic Studies in Pregnant Women and the Relevance of Pharmacometric Tools
Authors: Dallmann André , Mian Paola , den Anker Johannes Van , Allegaert Karel
Published: March 2019

Background:

In clinical pharmacokinetic (PK) studies, pregnant women are significantly underrepresented because of ethical and legal reasons which lead to a paucity of information on potential PK changes in this population. As a consequence, pharmacometric tools became instrumental to explore and quantify the impact of PK changes during pregnancy.

Methods:

We explore and discuss the typical characteristics of population PK and physiologically based pharmacokinetic (PBPK) models with a specific focus on pregnancy and postpartum.

Results:

Population PK models enable the analysis of dense, sparse or unbalanced data to explore covariates in order to (partly) explain inter-individual variability (including pregnancy) and to individualize dosing. For population PK models, we subsequently used an illustrative approach with ketorolac data to highlight the relevance of enantiomer specific modeling for racemic drugs during pregnancy, while data on antibiotic prophylaxis (cefazolin) during surgery illustrate the specific characteristics of the fetal compartments in the presence of timeconcentration profiles. For PBPK models, an overview on the current status of reports and papers during pregnancy is followed by a PBPK cefuroxime model to illustrate the added benefit of PBPK in evaluating dosing regimens in pregnant women.

Conclusions:

Pharmacometric tools became very instrumental to improve perinatal pharmacology. However, to reach their full potential, multidisciplinary collaboration and structured efforts are needed to generate more information from already available datasets, to share data and models, and to stimulate cross talk between clinicians and pharmacometricians to generate specific observations (pathophysiology during pregnancy, breastfeeding) needed to further develop the field.
Sildenafil for Antenatal Treatment of Congenital Diaphragmatic Hernia: From Bench to Bedside
Authors: Russo Francesca M. , De Bie Felix , Hodges Ryan , Flake Alan , Deprest Jan
Published: March 2019

Background:

Persistent pulmonary hypertension (PPH) is one of the main causes of mortality and
morbidity in infants affected by congenital diaphragmatic hernia (CDH). Since the structural changes that lead to
PPH take place already in utero, a treatment starting in the prenatal phase may prevent the occurrence of this
complication.

Objective:

To summarize the development process of antenatal sildenafil for CDH.

Methods:

The pharmacokinetics and efficacy of sildenafil have been assessed in the rat and the rabbit model. The
transfer of the drug through the human placenta has been measured with the ex-vivo placenta perfusion model.
Results from this experiment are being incorporated in a pregnancy-physiologically based pharmacokinetic (p-
PBPK) model. A phase I-IIb placental transfer and safety study is ongoing.

Results:

Sildenafil administration to pregnant rats and rabbits led to therapeutic foetal drug levels without maternal
and foetal toxicity, although it was associated with impaired vascular development in foetuses with nonhypoplastic
lungs. Peak concentrations and 24-hour exposure were higher in pregnant rabbits compared to nonpregnant
ones. In rat and rabbit foetuses with CDH, sildenafil rescued the lung vascular anomalies and partially
improved parenchymal development. Sildenafil crossed the human placenta at a high rate ex-vivo, independently
from the initial maternal concentration.

Conclusion:

There is preclinical evidence that maternally administered sildenafil prevents the vascular changes
that lead to PPH in CDH newborns. The phase I/IIb clinical study together with the p-PBPK model will define the
maternal dose needed for a therapeutic effect in the foetus. Foetal safety will be investigated both in the clinical
study and in the sheep. The final step will be a multicentre, randomized, placebo-controlled trial.
Advances in In-Silico based Predictive In-Vivo Profiling of Novel Potent β-Glucuronidase Inhibitors
Authors: Yousuf Maria
Published: March 2019

Background:

Intestinal β-glucuronidase enzyme has a significant importance in colorectal
carcinogenesis. Specific inhibition of the enzyme helps prevent immune reactivation of the glucuronide-
carcinogens, thus protecting the intestine from ROS (Reactive Oxidative Species) mediatedcarcinogenesis.

Objective:

Advancement in In-silico based techniques has provided a broad range of studies to
carry out the drug design and development process smoothly using SwissADME and BOILED-Egg
tools.

Methods:

In our designed case study, we used SwissADME and BOILED-Egg predictive computational
tools to estimate the physicochemical, human pharmacokinetics, drug-likeness, medicinal
chemistry properties and membrane permeability characteristics of our recently In-vitro evaluated
novel β-Glucuronidase inhibitors.

Results:

Out of the eleven screened potent inhibitors, compound (8) exhibited excellent bioavailability
radar against the six molecular descriptors, good (ADME) Absorption, Distribution, Metabolism
and Excretion along with P-glycoprotein, CYP450 isozymes and membranes permeability profile.
On the basis of these factual observations, it is to be predicted that compound (8) can achieve in-vivo
experimental clearance efficiently, Therefore, in the future, it can be a drug in the market to treat
various disorders associated with the overexpression of β-Glucuronidase enzyme such as various
types of cancer, particularly hormone-dependent cancer such as (breast, prostate, and colon cancer).
Moreover, other compounds (1-7, & 9-11), have also shown good predictive pharmacokinetics, medicinal
chemistry, BBB and HIA membranes permeability profiles with slight lead optimization to
obtain improved results.

Conclusion:

In consequence, in-silico based studies are considered to provide robustness for a rational
drug design and development approach to avoid the possibility of failures of drug candidates
in the later stages of drug development phases. The results of this study effectively reveal the possible
attributes of potent β-Glucuronidase inhibitors, for further experimental evaluation.
Biological Significance of Imidazole-based Analogues in New Drug Development
Authors: Chopra Pratiksha N. , Sahu Jagdish K.
Published: March 2019

In the field of heterocyclic medicinal chemistry, especially five-membered ring
structures containing a nitrogen atom, imidazole core is an imperative aromatic heterocycle which
is usually present in naturally occurring products and synthetic bioactive molecules. The
occurrence of imidazole moiety in therapeutic compounds may be beneficial in terms of improving
water-soluble properties due to its two nitrogen atoms which leads to the creation of hydrogen
bonds. The imidazole nucleus has also been recognized as an important isostere of triazole,
pyrazole, thiazole, tetrazole, oxazole, amide etc. for the purpose of designing and development of
various biologically active molecules. Moreover, imidazole core as an attractive binding site could
interact with diverse cations and anions as well as biomolecules through different reactions in the
human biological system thus displaying extensive biological activities. This effort thoroughly
provides a wide-ranging assessment in current drug discovery and developments of imidazolebased
analogues in the entire series of synthetic medicinal chemistry as antibacterial and
antifungal, anticancer, anti-tubercular, analgesic and anti-inflammatory, anti-neuropathic,
antihypertensive, anti-allergic, anti-parasitic, antiviral, antidepressant, anti-obesity and so on,
altogether with their prospective approaches in diagnostic and pathological field. It is expected
that the present review will be supportive on behalf of new opinions in the search for rational
strategies of more efficacious and less toxic medicinal agents and drugs containing imidazole core.
Aging Affects Nicotinic Acetylcholine Receptors in Brain
Authors: Utkin Yuri N.
Published: March 2019

Background:

Aging is a common and inevitable stage in the life cycle of higher organisms.
Different organs, including the central nervous system, are affected by aging in different ways.
Many processes are involved in aging, and neurodegeneration is one of the aging processes in which
the central nervous system is engaged. Brain degeneration during normal aging underlies cognitive
disorders experienced by older people. Not all molecular mechanisms associated with age-related
neurodegeneration are fully understood; however, there is a whole range of data on the participation
of nicotinic acetylcholine receptors in the processes of aging and neurodegeneration. Two main subtypes
of nicotinic acetylcholine receptor α7 and α4β2 present in the central nervous system are affected
by these processes. The loss of these receptor subtypes during normal aging is one of the reasons
for the cognitive impairments. The decrease in nicotinic acetylcholine receptors is also very important
for the pathogenesis of age-related neurodegenerative diseases. Thus, the drugs enhancing receptor
functions may be considered promising for the treatment of cognitive dysfunction in the aged
people.

Conclusion:

To achieve healthy longevity, the molecular processes that occur during aging should be
established. In this regard, the participation and role of nicotinic acetylcholine receptors in the brain
aging and degeneration are considered in this review.
Functional Nanomaterials and Their Potential Applications in Antibacterial Therapy
Authors: Hong Le , Luo Shu-Han , Yu Chen-Hao , Xie Yu , Xia Meng-Ying , Chen Ge-Yun , Peng Qiang
Published: March 2019

In the past decades, nanomaterials have shown great potential in biomedical fields, especially in drug delivery, imaging and targeted therapy. Recently, the development of novel functional nanomaterials for antibacterial application has attracted much attention. Compared to the traditional direct use of antibiotics, antibacterial nanomaterials either as drug delivery systems or active agents have a higher efficacy and lower side effects. Herein, we will focus on the antibacterial applications of four commonly used nanomaterials, including metal-based nanomaterials, polymeric nanoparticles, graphene oxides or carbon-based nanomaterials and nanogels.
A hybrid depressive mood analysis model to detect blogger depression tendency from web posts (Preprint)
Authors: Tung ChiaMing , Lu WenHsiang
Published: March 2019

UNSTRUCTURED

n recent years, reports of suicide have continuously increased because of people suffering from tremendous pressure or depression. Depression is listed as the third highest health issue from the World Health Organization. They also predict that depression will become the second highest issue by 2020. This kind of mental illness is difficult to diagnose and detect. In our previous works, we proposed a Negative Emotion Evaluation (NEE) model and an Event-Driven Depression Tendency Warning (EDDTW) model to early detect depressive moods. In this work, we combine the previous models to propose a Hybrid Depressive Mood Analysis (HDMA) model to predict the depression from web posts. The experimental results show that our proposed hybrid depressive mood analysis model obtains over 70% precision.
Широкополосный СВЧ-аттенюатор, выполненный по мостовой структуре
Authors: Репин В. , Мухин И. , Дроздецкий М. , Алексеев Г.
Published: March 2019

Представлена оригинальная структура СВЧ-аттенюатора, изготовленного по КМОП КНИ-технологии. Особенность данной структуры – возможность непрерывной регулировки ослабления благодаря использованию в качестве переменных импедансов сопротивления канала полевых транзисторов. Частотный диапазон эффективного ослабления аттенюатора 1–12 ГГц при коэффициенте ослабления не менее 32 дБ, в более узкой полосе частот ослабление превышает 50 дБ.
Экономические аспекты развития микроэлектроники КНР
Authors: Макушин М. , Фомина А.
Published: March 2019

Анализируется современное состояние микроэлектроники КНР. Отмечается, что дальнейшее развитие микроэлектроники КНР связано с более глубоким встраиванием в национальную экономику, использованием новых подходов и технологий, включая искусственный интеллект. Руководством страны поставлена задача увеличения внутреннего производства ИС в целях снижения зависимости от импортной продукции.
Необходимость межлабораторных сличений в современной метрологии
Authors: Кривов А. , Смирнова Е. , Бондин К. , Николаев П.
Published: March 2019

В практике метрологического обеспечения электронных производств все большее значение приобретает такая технология достижения и поддержания требуемой точности промышленных измерений, как межлабораторные сравнительные испытания (МСИ). В статье рассмотрены вопросы реализации требований действующих стандартов в части, относящейся к МСИ, и приведены краткие сведения о пилотном проекте по МСИ результатов калибровки и поверки электроизмерительных приборов, выполненном компанией «Диполь».
La ventaja competitiva de México en el TLCAN: un caso de dumping social visto desde la industria automotriz
Authors: Covarrubias Alex
Published: March 2019

Las negociaciones para un nuevo TLCAN han puesto el foco de atención en la industria automotriz mexicana (IAM). Con una participación cada vez mayor en los mercados, empleos e inversiones de cartera en la región y al dar cuenta del 90% del déficit comercial de E.U. con México, la IAM es una pieza clave para la conformación de un nuevo TLCAN. El presidente Trump ha hecho de la IAM el blanco de sus críticas, pues la considera el mejor ejemplo de un tratado mal instrumentado por E.U. De ahí que sea oportuno buscar nuevas explicaciones sobre las bases de la ventaja competitiva de la IAM. Este estudio se fundamenta en teorías del ciclo de negocios e inversiones y en conceptos de anclaje de mercado e institucional para evaluar las condiciones de competitividad de la IAM bajo el TLCAN. Su propuesta es que la IAM ha funcionado bajo políticas de dumping social, por lo que su posición en los mercados regionales y globales se basa en fuentes no legítimas de ventaja comparativa.
Nuevos excluidos en el sistema educacional chileno: problemas y desafíos
Authors: Cornejo Espejo Juan
Published: March 2019

El artículo es una reflexión crítica acerca de los alcances y desafíos de la inclusión educativa, ya que esta se ha centrado casi exclusivamente en la atención de estudiantes con necesidades educativas especiales. Los otros grupos excluidos en la escuela tradicionalmente han sido omitidos, invisibilizados o silenciados, motivo por el cual su irrupción en escena supone nuevos retos. El artículo está dividido en tres partes: la primera problematiza los significados e implicancias de la inclusión educativa. La segunda cuestiona los proyectos integradores que promueven la asimilación, normalización e invisibilización de las diferencias. En la tercera parte se esbozan algunas ideas que apuestan por la deconstrucción de los paradigmas que sustentan la exclusión en tanto exigencia para una auténtica inclusión educativa.
El problema, ¿está en la casa? Relaciones personales y exclusión educativa en la Ciudad de Buenos Aires (2001-2010)
Authors: De Grande Pablo
Published: March 2019

En este artículo se analizan los cambios en los condicionantes de la exclusión educativa para la educación media en la Ciudad de Buenos Aires en el período 2001-2010. A partir de información censal, se estimaron modelos de probabilidades por regresiones logísticas, que permitieron cuantificar el peso relativo de los factores relacionales, individuales y residenciales en las situaciones educativas de los jóvenes de la ciudad. Como principales resultados se destacan la alta variabilidad de las chances de asistencia escolar en función de la relación de los jóvenes con la jefatura del hogar, la sensibilidad a la presencia de niños pequeños en los hogares y la decreciente elasticidad de la asistencia con respecto a las condiciones materiales de hábitat, bienes y servicios de las viviendas.
Inclusión educativa en la escuela secundaria. Una experiencia exitosa
Authors: Garino Delfina
Published: March 2019

Aunque desde 2006 se estableció la obligatoriedad legal del nivel secundario completo en Argentina, se observan problemas vinculados a la retención y al desarrollo de procesos educativos significativos para quienes aprenden. El propósito de este artículo es analizar, desde una perspectiva metodológica cualitativa, la propuesta educativa de una escuela secundaria que ofrece formación para el trabajo. Se retoma la voz de sus egresados para examinar la inclusión de los jóvenes a la escuela secundaria (en términos de retención) y en la escuela secundaria (en términos de desarrollo de procesos de aprendizajes significativos). Entre los hallazgos se destaca la valoración del seguimiento personalizado y de la formación para el trabajo como estrategias que posibilitaron la inclusión educativa.
Instrucción específica en la mejora del desempeño ortográfico: una revisión de programas de intervención
Authors: Palombo Ana Laura , Cuadro Ariel
Published: March 2019

El objetivo de este estudio es presentar una revisión de los programas de intervención en ortografía que han mostrado evidencia de mejoras. A partir del análisis de 419 artículos identificados, se seleccionaron 12 que cumplían la condición de desarrollar específicamente un plan de intervención en ortografía. Los resultados establecen un alto nivel de sistematización, regularidad y especificaciones en las intervenciones, donde se consideran tanto aspectos cognitivos como instruccionales. Para que el programa tenga un impacto efectivo, debe tener una frecuencia de trabajo definida, considerar el tipo de palabra, el análisis fonológico y la escritura implementadas interactivamente en actividades planificadas sistemáticamente.
Perhitungan Ketebalan Bahan Komposit Karet Alam dan Timbal Oksida Sebagai Pelindung Radiasi Sinar-X 100 Ke
Authors: Prayitno Gunarwan , Gunawan Pancatatva H
Published: March 2019

Telah dilakukan perhitungan  ketebalan bahan komposit karet alam timbal oksida sebagai pelindung radiasi sinar-x 100 Kev. Perhitungan bertujuan untuk memperoleh ketebalan bahan proteksi radiasi yang aman bagi lingkungan atau pekerja dilingkungan medan radiasi. Perhitungan kemampuan daya serap bahan komposit karet alam timbal oksida dilakukan pada energy 100 Kev. Dasar perhitungan daya serap komposit karet alam timbal oksida sebasar 50 pphr (part per hundred rubber) sampai dengan 1000 pphr. Tebal komposit karet alam timbal oksida yang akan diukur setebal 2,5 mm. hasil perhitungan menunjukan bahwa ketebalan bahan komposit karet alam timbal oksida yang aman bagi pengguna atau para pekerja dimedan radiasi, apabila karet alam dicampur dengan timbal oksida sebanyak 550 pphr, nilai daya serap pada 550 pphr telah memenuhi standart yang diizinkan.
Proses Pembuatan Selongsong Tabung Pelindung Detector Geiger Muller Tipe Side Window
Authors: Prayitno Gunarwan , Sinduningrum Estu
Published: March 2019

Pembuatan pelindung detector Geiger Muller salah satunya untuk melindung detector tersebut dari benturan benda keras saat digunakan. Pada waktu penguunaaan umumnya detector diletakan terdepan dalam sistim rangkaian deteksi.untuk mendapatkan hasil cahan maksimum, oleh karena itu setiap detector harus dilindungi oleh suatu bahan yang tahan benturan benda keras, tetapi tidak mengurangi jumlah cacahan detektor. Batangan aluminium solid dibubut  hingga menyerupai tabung, salah satu bagian ujung dibuat drat atau  ulir, dudipersiapkan untuk penutup . sehingga seluruh bagian detector tertutup oleh aluminium, dipilih bahan pelindung yang tidak bersifat penyerap radiasi atau (absorber). Pada pembuatan ini dipilih suatu bahan tipe Alumunium solid, dengan alasan mudah didapat dipasaran dengan harga terjangkau. Pembuatan selongsong tabung detector merupakan penyempurnaan dan penyelesaian tahap akhir pembuatan detector Geiger Muller tipe side window.
Pembuatan Tungku Induksi Sederhana
Authors: Syahbardia Syahbardia , Somantri Herman , Suryaman Aldi
Published: March 2019

Tungku  induksi merupakan salah satu alat untuk proses pemanasan logam yang saat ini banyak digunakan di lingkungan industri, yang mana alat ini digunakan untuk melebur atau memanaskan logam. Maka dari itu untuk mengikuti perkembangan zaman dan untuk mempelajari kinerja tungku  induksi agar dapat memahami dan mengetahui prinsip kerja dari pemanas induksi maka dari itu dilakukan penelitian  pemanas atau tungku  induksi sederhana .

Metodologi  penelitian dimulai dengan : perancangan yaitu, pemilihan sistem pemanas induksi sederhana, menentukan komponen-komponen yang digunakan , proses pembuatannya dan melakukan pengujian pada pemanas induksi sederhana. Dalam proses pengujian dilakukan dua tahap pengujian yaitu proses pengamatan visual yang bertujuan untuk mengetahui apakah komponen pemanas induksi bekerja sesuai dengan yang diinginkan, lalu tahap selanjutnya dilakukan pengujian prestasi,berupa pengukuran untuk mengetahui besar daya yang digunakan dan besar pemanasan yang dihasilkan pada logam uji. Pembuatan pemanas induksi ini menghasilkan alat yang mampu memanaskan logam mencapai suhu 465oC selama 10 menit dengan nilai kalor yang dihasilkan sebesar 12192,3J dengan efisiensi thermal  sebesar 12.7%.
Analisa Penyebab Kegagalan Kemasan Cup Minuman Instan Aloe Vera
Authors: Mahaji Puteri Renty Anugerah , Prasetyawati Meri
Published: March 2019

- IKM mempunyai peran penting dan strategis dalam pembangunan ekonomi nasional. Selain berperan dalam pertumbuhan ekonomi dan penyerapan tenaga kerja, juga berperan dalam mendistribusikan hasil-hasil pembangunan. Dalam hal ini adalah IKM yang berlokasi di Kebon Pala Kecamatan Makasar Jakarta Timur yang berbahan baku herbal yang kemudian diolah menjadi makanan dan minuman. Salah satu dari sekian tanaman herbal yang digunakan adalah lidah buaya atau aloe vera. Pada studi pendahuluan yang telah dilaksanakan, diketahui permasalahan yang ditemui pada IKM tersebut diantaranya adalah masih ada dampak dengan adanya kemasan cup minuman instan aloe vera diantaranya penyok, pecah, Maka dibuatlah rancangan solusi yang ditawarkan untuk menyelesaikan masalah tersebut diatas berupa perancangan ulang kemasan cup minuman instan aloe vera. Tujuan dari penelitian ini diantaranya mengidentifikasi atribut apa saja dalam diperlukan dalam menentukan kemasan cup minuman aloe vera dan memberikan usulan dalam menentukan kemasan cup minuman aloe vera. Metode penelitian yang digunakan adalah analisa penyebab dengan Fishbone Diagram dan analisa dengan Failure Methode And Effect Analysis yang terdiri dari identifikasi proses atau produk, analisis kemungkinan setiap potensi mode kegagalan, analisis efek yang ditimbulkan dari terjadinya setiap potensi kegagalan (potential failure mode), menentukan peringkat atau ranking, menghitung nilai Risk Priority Number atau RPN, membuat daftar prioritas perbaikan untuk memperbaiki atau mencegah terjadinya potensi mode kegagalan (potential failure mode), serta membuat analisis usulan perbaikan. Didapat hasil bahwa penyebab kegagalan adalah belum adanya SOP, belum adanya waktu standar melakukan proses pengemasan, ukuran penutup cup dengan meisn kurang sesuai. Tidak adanya pengaturan suhu dan material kemasan kurang sesuai.
Pemodelan dan Simulasi Proses Adsorpsi Gas Pengotor oleh Molecular Sieve pada Pendingin Rde dengan Software Chemcad
Authors: Sriyono Sriyono , Hilda Atiqah M. , Kamayani Mia
Published: March 2019

The purity of RDE10 helium coolant should be maintained from various impurities gas due to water/air ingress that reacts with the reflector graphite (C). These impurities are CH4, CO, CO2, H2O, H2, O2, and N2 which can initiate oxidation corrosion or carburization-decarburization so the concentration should be maintain to be a minimum. The helium coolant is purified by Helium Purification System (HPS). One of the stages in HPS is adsorption by Molecular Sieve mainly for CO2 and H2O molecules. This paper discusses the influence of pressure, known as pressure swing adsorption (PSA) on the adsorption ability of the Molecular Sieve aims to determine the most effective pressure that will be operated on Molecular Sieve column. Molecular Sieve is modeled with CHEMCAD computer code in two columns, one column for the adsorption process, and the other for the regeneration (desorption). Adsorption methods used in the analysis is the Langmuir method. Models that have been developed simulated by providing input: total flow rate of 10.5 kg/hour, 30 °C, porosity 0.7, bed height 2 m, pore diameter 5 A, and the amount of O2 and N2 impurities respective each 1 g/s. The pressure varies between 5 to 50 bars, and the Molecular Sieve adsorption capability is analyzed. Simulation results show that with the increase in pressure of 5 to 50 bar, indicating an increase in Molecular Sieve absorption capacity to CO2 is 15.90% and to H2O is 15.80%. In the SPH design, the input stream to the Molecular Sieve must be compressed until 50 bar to obtain high absorption capability of the CO2 and H2O.
ATIVIDADE CIENTÍFICA QUALIFICADA NOS PROGRAMAS DE PÓS-GRADUAÇÃO EM ENFERMAGEM: UM ESTUDO BIBLIOMÉTRICO
Authors: Reis Helca Franciolli Teixeira , Santos Mateus Carmo , Bispo de Almeida Claudio , Vilela Alba Benemérita Alves , Yarid Sérgio Donha
Published: March 2019

Objetivou-se analisar a produção científica docente nos Programas de Pós-Graduação em Enfermagem no Brasil que obtiveram conceitos 6 e 7 na avaliação CAPES 2013-2016.  Trata-se de um estudo bibliométrico das produções científicas de 155 docentes de Programas de Pós-Graduação em Enfermagem brasileira, coletadas por meio dos currículos lattes, no período de junho à julho de 2017, posteriormente, realizou-se as análises descritivas. A maior parte dos professores avaliados foram do sexo feminino, com formação em Enfermagem, não apresentam índice H e não possuem bolsa de produtividade, entretanto, concentram sua produção científica em artigos, com publicações em periódicos com Qualis elevados (A1 à B1). Conclui-se que os Programas de Pós-Graduação em Enfermagem no Brasil, que obtiveram conceitos 6 e 7 na avaliação CAPES 2013-2016, são compostos por maioria de docentes que apresentam produção científica qualificada de acordo as exigências da Política de Pós-Graduação Brasileira, porém ainda não suficientes para garantir uma aquisição de verbas que sejam suficientes para produção de pesquisa.
The influence of the expression of steroid receptors on angiogenesis, proliferation and apoptosis in myomas of pre- and postmenopausal women
Authors: Kljakic Dusko , Raicevic Sasa , Milosavljevic Milos , Ilic Milena , Zivanovic Aleksandar , Radonjic Dragan , Mitrovic Slobodanka
Published: March 2019

Introduction/Objective. The aim of this study was to determine the effects of the estrogen and progesterone receptor status on angiogenesis, proliferation, and apoptosis of myoma cells in premenopausal (PreM) and postmenopausal (PostM) women. Methods. This was a cross section; clinical-experimental, retrospective, non-interventional study in the field of the study of fundamental pathogenesis mechanisms of disease using pathohistological materials from the existing archive. The research included 76 patients diagnosed with uterine leiomyomas, operatively treated in the Clinic for Gynecology and Obstetrics, Clinical Centre Kragujevac, Serbia. According to the menstrual status, we formed two experimental subgroups. The first group was PreM women (n = 35; 46.2 ? 5.02 years old), and the second group was PostM women (n = 41; 60.25 ? 5.41 years old). Hematoxylin-eosin staining for myoma and myometrium was conducted, as well as immunohistochemistry for ER?, ER?, PR?, vascular endothelial growth factor, endoglin, Ki67, and caspase-3. Results. Progesterone receptor was overexpressed in myoma and myometrium of PreM compared to myoma and myometrium of PostM women. Expression of caspase-3 was a statistically significant increase in PostM women compared to PreM group. ER? and ER? were not changed among groups neither in myoma nor in myometrium samples. Conclusion. According to our data, PR? had higher influence on apoptosis and cell growth than estrogen receptors. Since PR? was increased in PreM in both myoma and myometrium, probably this expression led further to lower expression of apoptotic marker in PreM women.
A sparse principal component analysis of Class III malocclusions
Authors: Kang Tae-Joo , Eo Soo-Heang , Cho HyungJun , Donatelli Richard E. , Lee Shin-Jae
Published: March 2019

Objectives:

To identify the most characteristic variables out of a large number of anatomic landmark variables on three-dimensional computed tomography (CT) images. A modified principal component analysis (PCA) was used to identify which anatomic structures would demonstrate the major variabilities that would most characterize the patient.

Materials and Methods:

Data were collected from 217 patients with severe skeletal Class III malocclusions who had undergone orthognathic surgery. The input variables were composed of a total of 740 variables consisting of three-dimensional Cartesian coordinates and their Euclidean distances of 104 soft tissue and 81 hard tissue landmarks identified on the CT images. A statistical method, a modified PCA based on the penalized matrix decomposition, was performed to extract the principal components.

Results:

The first 10 (8 soft tissue, 2 hard tissue) principal components from the 740 input variables explained 63% of the total variance. The most conspicuous principal components indicated that groups of soft tissue variables on the nose, lips, and eyes explained more variability than skeletal variables did. In other words, these soft tissue components were most representative of the differences among the Class III patients.

Conclusions:

On three-dimensional images, soft tissues had more variability than the skeletal anatomic structures. In the assessment of three-dimensional facial variability, a limited number of anatomic landmarks being used today did not seem sufficient. Nevertheless, this modified PCA may be used to analyze orthodontic three-dimensional images in the future, but it may not fully express the variability of the patients.
The Theory Practices Gap among Nursing and Midwifery Students in Palestine
Authors: Amro Nawaf RN , Ayham Slimi Ayat Al Sous, Shatha Shkherat, Haya Nahli, Rajeh Hassasneh,
Published: March 2019

Clinical experience is one of the most significant sources of stress and anxiety producing components of the nursing program. Clinical training, not only gives students the opportunity to transfer what they have learnt during theory into the unfamiliar and complex clinical practice environments. It also helps students learn a variety of skills, such as how to establish communication, make decisions and work as a member of a team. The purpose of this study was to identify nursing and midwifery students’ problems during clinical practice at the baccalaureate nursing program in Palestine. Descriptive cross-sectional study design was utilized. A stratified sample of 340 nursing and midwifery students was recruited. Data were collected on a self-administered questionnaire. The sample was derived from students who had experienced clinical practice among the students in the department of nursing and midwifery sciences in Al-Quds University in Palestine. The study started with 340 students, including 155 males and 185 females. The final analysis was conducted with 330 participants comprising 151 (45.8%) males and 179 (54.2%) females. The majority of respondents stated that they did perceive a difference between what they were taught in the classroom compared to what was used in their clinical experiences with 237 (71.8%) responding yes and 93 (28.2%) responding no. Approximately, half of the students perceived the extent of the gap between theoretical & practical side with 138 (41.8%) responding big. Therefore, nursing facilitators should train and make more researches to identifying more problems and working to enhancing these problems to have a professions nursing and midwifery in our life.
Safety and Efficacy of a Combination of Chloramphenicol, Polymyxin-B and Dexamethasone in Ocular Infection with Inflammation
Authors: Dilip Kiran Dr. Mayuresh , Lalit Jeevan Pawaskar Shaheen Naseem Sheikh,
Published: March 2019

Introduction: Ocular infection with inflammation is very common in developing countries like India. Multi-drug therapy is used in the treatment of Ocular infection with inflammation. We studied the safety as well as efficacy of one such combination anti-bacterial (Chloramphenicol and Polymyxin -B) and corticosteroid (Dexamethasone) in the treatment of Ocular infection with inflammation especially mild keratitis and conjunctivitis.

Methodology: Out of 151 patients, 117 were completed the study. Efficacy assessment was made by reduction in Visual Analogue Scale (VAS) Score of Ocular hypermia, Ocular discharge, Keratitis and Conjunctivitis related to Ocular infection with inflammation. Safety assessment was made by inspecting the adverse events during the study.

Results: Reduction in mean VAS score was analysed from 4.47 (baseline) to 2.76 (day 3) to 0.55 (day 5) of ocular hypermia, from 3.42 (baseline) to 2.03 (day 3) to 0.24 (day 5) of ocular discharge, 3.57 (baseline) to 1.89 (day 3) to 0.21 (day 5) of keratitis and from 3.84 (baseline) to 2.10 (day 3) to 0.20 (day 5) of conjunctivitis. Majority of patients had more than 90% reduction in their VAS score at conclusion visit in all the parameters. 8.54% of adverse events of mild intensity was observed.

Conclusion: A fixed dose combination of Chloramphenicol, Polymyxin-B and Dexamethasone of is safe and effective in the treatment of Ocular infection with inflammation.
A Rare Case of an Ophthalmologic Emergency: Idiopathic Central Retinal Artery Occlusion
Authors: Maryam Abdulla,
Published: March 2019

Central retinal artery occlusion is a form of an acute stroke in the eye and is regarded as an ophthalmic emergency.[1,2] This paper presents a case of Central retinal artery occlusion in an 18-year-old pregnant female who presented with sudden loss of vision in her right eye and was diagnosed with central retinal artery occlusion. The aim of this paper is to illustrate the clinical presentation, diagnosis and treatment but mainly focusing on the underlying etiologies.

Recent literature shows no reported cases explaining the possibility of retinal artery occlusion occurring in a young pregnant female who is otherwise free of any medical conditions.[3] Due to the serious consequence, limited knowledge and treatment in the field of unexplained retinal occlusion in pregnancy; it’s encouraged that more efforts are invested in research and reporting cases for a better understanding of the possible and future management options and preventative strategies of central retinal occlusions.
Depression in Elderly Patients Attending the Psychiatric Outpatient Department: A Cross Sectional Study
Authors: Sharma Dr. Ravi C , Sharma Dr. Dinesh Dutt , Parkash Dr. Kamal
Published: March 2019

Background: Cognitive impairment is a common clinical condition among elderly patients suffering with depression and has a well-known aetiology. The present study planned to determine the prevalence of cognitive impairment and depression in geriatric patients attending Psychiatric outpatient department services.

Methods: The study was a prospective cross-sectional one and carried out with a sound methodology on elderly patients attending the Psychiatric OPD of Indira Gandhi Medical College, Shimla-1, Himachal Pradesh. A total of 130 patients were screened, out of which 105 patients have fulfilled the inclusion criteria and enrolled after written informed consent form. The cognitive function and depression were assessed by using standardized Mini-Mental State Examination of Folstein (MMSE) and the Geriatric Depression Scale (GDS), respectively.

Results: Prevalence of cognitive impairment was found 42.9% (44.2% in women, 35.5% in men), whereas the prevalence of depression was found 48.6% (56.30%women, 41.10% men) which was statistically significant (p<0.05).Conclusions: Cognitive impairment and depression were found to be more prevalent in the females than in the males. So, it is advised that psychiatrist should provide special attention for early detection and treatment of depressive symptoms in elderly patients suffering with cognitive impairment.
Iliopsoas Haematoma Presenting with Femoral Neuropathy during Anticoagulation Therapy with Warfarin
Authors: Jayaprakash H Rajesh Kishan Rao, Girish Basappa,
Published: March 2019

Iliopsoas haematoma is a rare complication of anticoagulation therapy, presents with sudden onset of groin or flank pain, with or without neurological manifestation of the lower extremity due to femoral neuropathy. Computed Tomography of abdomen and pelvis is the most useful tool for diagnosis. Treatment options are conservative therapy, surgical decompression, ultrasound guided percutaneous drainage or trans-catheter arterial embolisation. We report a case of iliopsoas haematoma, in a 28 years old male, post aortic valve replacement on oral anticoagulation therapy, presenting with right groin and flank pain with paraesthesia of right lower limb.
Under 5 Children Mortality in Sudan: Situation Analysis
Authors: Abdeldafie Selwa Y
Published: March 2019

Sudan like other developing countries suffers a high mortality rate among under 5 children. Although there is an steady minimal reduction of this rate among Sudanese children but it is still high even after implementing many policies and interventions by the federal government.

The aim of this work is to analyze the situation of under 5children mortality in Sudan in term of trend, causes of death, policies and interventions under taken to reduce this risk. Methods :the Sudan annual statistical report of 2015 was reviewed, it revealed that : the trend of under 5children mortality in Sudan is 70.10 as of 2015 and this is the lowest value while the highest one is 178.40 in the year 1960.There are a lot of policies under taken by the government to reduce this risk like : diarrhea community treatment , antenatal corticosteroids , postnatal care and IMCI implementation and the essential interventions which are implemented include :exclusive breastfeeding, skilled birth attendance, postnatal care, early initiation of breastfeeding , access to improved drinking- water sources, pneumonia care-seeking and pneumonia antibiotics.
Demographic and Clinical Profile of Anterior Uveitis Patients Presenting in a Tertiary Eye Care Hospital
Authors: Chandravanshi Shivcharan Lal
Published: March 2019

Introduction - Anterior uveitis is referred as an inflammation of the iris and ciliary body. Anterior uveitis is the most common type of uveitis and frequently affecting young adults. Aim of this study was to evaluate the clinical presentation, etiology, pathological pattern, complications and treatment outcome of anterior uveitis in the Rewa district of Madhya Pradesh.

Materials and Methods - A Prospective, hospital based, interventional study was conducted on all anterior uveitis patients, treated at the Department of ophthalmology, S. S. Medical College, Rewa, Madhya Pradesh for the period of two years from January 2016 to December 2017.

All patients aged 0-80 years that were treated for anterior uveitis are taken in consideration. Complete ophthalmic evaluation, necessary lab investigations and imaging were performed to establish the etiology.  Demographic data, uveitis characteristics, pathological pattern, investigations, etiology, complications and the treatment outcome were collected for each patient. Patients of anterior uveitis with incomplete investigations, intermediate, posterior and panuveitis, postoperative uveitis, sympathetic ophthalmia, endophthalmitis and masquerade syndromes were excluded from study.

Results - Present study included 212 patients over a period of two years (January 2016 to December 2017). Anterior uveitis affect most frequently in the 5th decade of life (33.96%). Majority of patients had non-granulomatous type of uveitis (73.11%). Etiology of anterior uveitis remained unknown (idiopathic) in 126 cases (59.43%). The most common etiology identify in present study is tuberculosis in 47 cases (22.16%) followed by syphilis in 8 cases (3.77%). The most common complication of anterior uveitis is complicated cataract 18 cases (8.49%) followed by secondary glaucoma in 8 cases (3.77%).

Conclusion - This study gives valuable information on clinical and demographic characteristics of anterior uveitis in resident of the Rewa, district of Madhya Pradesh.
Lipid Profile in HIV Infected Children Receiving Antiretroviral Treatment
Authors: Lall Dr. Kavita J. , Khurana Dr. Omesh , Ambad Dr. Ranjit S
Published: March 2019

This study reviewed the lipid profile of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients in relation to use of antiretroviral therapy (ART). Lipid profile is becoming one of the common problems in human immunodeficiency virus infected patients receiving antiretroviral therapy. Data on lipid profile derangements induced by antiretroviral treatment. The aim of this study was to assess the lipid profile abnormalities in HIV infected children receiving ART.

Material and Method - Information on sex, age, specific ART type in use , ART start date, duration of treatment, duration of HIV infection, BMI, relevant signs and symptoms and medications if any were collected by trained nurses using structured questionnaires and patients medical record.

Blood Sample Collection, Transport and Processing - Following a standard and safety collection procedure, about 5 ml fasting venous blood was taken from the patients and the control groups by clinical nurses and senior laboratory technologist. Fasting serum samples were analyzed for total cholesterol (TC), triglyceride (TG), High Density Lipoprotein- Cholesterol (HDL-c). Low density lipoprotein cholesterol (LDL) and Very low density lipoprotein (VLDL) was determined by Friedewald Equation (13).  

Result and conclusion - There was statistically significant difference between the two groups for TC, TG, TC/HDL-c ratio and TG/HDL –c ratio. On the basis of our study we concluded that the level of TG, TC, HDL-c and VLDL-c is high in HIV positive populations receiving first line ART (group I) as compared to ART naïve (group II). Considering that these altered lipid profiles can be an independent risk factors for coronary artery diseases and myocardial infarction, treatment with first-line ART may actually have potential risks for cardiovascular health of HIV positive people receiving ART.
Study of Comparing Combined Viscocanalostomy - Trabeculectomy to Trabeculectomy for the Management of Glaucoma
Authors: Verma Dr. Anand , Kaushal Dr. Pratibha
Published: March 2019

Purpose: To compare combined viscocanalostomy - trabeculectomy to trabeculectomy in Primary Open angle glaucoma. Material and Methods: A total of 20 patients (40 eyes) of bilateral Primary Open Angle Glaucoma (POAG) were included in this study. They were randomly divided into two groups. Twenty eyes underwent combined viscocanalostomy - trabeculectomy and other twenty eyes underwent trabeculectomy with releasable suture. Combined viscocanalostomy - trabeculectomy constituted lamellar sclera flap, deep sclera flap dissection, excision of deep sclera flap, deroofing of sclemn’s canal, viscodilatation of sclemn’s canal, trabeculectomy and tight flap closure. Success criteria included intraocular pressure < 14 mmHg or more than 30% reduction of IOP. Result: Although in both the groups IOP was decreased, there was more lowering of IOP in combined viscocanalostomy -trabeculectomy than trabeculectomy. Target IOP was achieved in 95 % in viscocanalostomy - trabeculectomy group compared to 85% in trabeculectomy group.