bluuebunny/crossref_metadata_2025 huggingface dataset:
Child Health in Latin America
Authors: Landmann Szwarcwald Célia , do Carmo Leal Maria , da Silva de Almeida Wanessa , Barreto Mauricio Lima , Frias Paulo Germano de , Theme Filha Mariza Miranda , Domingues Rosa Maria Soares Madeira , Franca Elisabeth Barboza , da Gama Silvana Granado Nogueira , Boccolini Cristiano Sigueira , Victora Cesar
Published: July 2019

Child health has been placed at the forefront of international initiatives for development. The adoption of the Millennium Development Goals has propelled worldwide actions to improve maternal and child health. In the course of the year 2000, the Latin American (LA) countries made marked progress in implementing effective newborn and infant life-saving interventions. Under-five mortality in LA fell by a third between 1990 and 2015, with a sharp decline in diarrheal diseases and respiratory infections. Due to the successful immunization programs in the region, some vaccine-preventable diseases have been eliminated. Many of the LA countries have reached nearly universal coverage of childbirths attended by skilled personnel and >80% coverage for antenatal care. In 2015, 18 countries in the region reported the elimination of mother-to-child transmission for both HIV and syphilis.

Although the advances in the public agenda aimed at promoting child health and development in Latin American countries are undeniable, unresolved issues remain. While many stillbirths and neonatal deaths could be averted by improving access to antenatal, intra-partum, and postnatal interventions, Latin America has the highest cesarean rate among all regions of the world with an excessive number of such operations without medical indications. The simultaneous lack and excess of cesarean deliveries in LA countries reflects a model of care that excludes a considerable portion of the population and reveals the persistent gaps and inequalities in the region. One of the main challenges to be faced is the lack of sustainable financing mechanisms to provide integrated and high-quality health care to all children, equal education opportunities, and social services to support disadvantaged families. When planning interventions, equity should be restored as the guiding principle of actions to ensure inclusion and social justice. Children represent the future of society in Latin America and elsewhere. For this reason, social commitment to provide universal child health is the genesis of sustainable development and must be an absolute priority.
Agreement on the Rescue and Return of Astronauts and Objects Launched into Outer Space
Authors: Marboe Irmgard
Published: July 2019

The Agreement on the Rescue and Return of Astronauts and the Return of Objects Launched into Outer Space (ARRA) of 1968 deals with the obligation of states toward astronauts in distress or in emergency situations and with the obligation to return space objects. It is the second of the five United Nations space treaties, after the Outer Space Treaty (OST) of 1967 and before the Liability Convention (LIAB) of 1972. The historical development of ARRA and how this agreement reflects the needs and interests of the two important space-faring nations at the time of its entry into force, the United States and the Soviet Union, are important factors for understanding the space race. ARRA is related to the OST and regards the various obligations of states concerning rescue and assistance as well as the return of astronauts, which stand in the middle between a general humanitarian duty and political and national security considerations. The return of space objects and the question of costs of rescue and return operations are important concerns and can be compared to the situation with the law of the sea, the United Nations Convention on the Law of the Sea (UNCLOS) of 1982 and the Convention for the Unification of Certain Rules of Law Respecting Assistance and Salvage at Sea (Salvage Convention) of 1989.

ARRA has never been applied with respect to accidents or distress of astronauts or cosmonauts but several times with respect to the recovering and returning of space objects. Finally, current challenges, such as the commercialization and privatization of outer space activities need to be addressed. This includes the increased interests of private individuals to enter outer space (so-called space tourism) and the question of the application of the ARRA to suborbital flights. Many legal challenges created by technological progress can be resolved via an evolving interpretation and application of the ARRA. Yet, some issues might warrant a new legal framework.
Adiabatic Quantum Computing and Quantum Annealing
Authors: Grant Erica K. , Humble Travis S.
Published: July 2019

Adiabatic quantum computing (AQC) is a model of computation that uses quantum mechanical processes operating under adiabatic conditions. As a form of universal quantum computation, AQC employs the principles of superposition, tunneling, and entanglement that manifest in quantum physical systems. The AQC model of quantum computing is distinguished by the use of dynamical evolution that is slow with respect to the time and energy scales of the underlying physical systems. This adiabatic condition enforces the promise that the quantum computational state will remain well-defined and controllable thus enabling the development of new algorithmic approaches.

Several notable algorithms developed within the AQC model include methods for solving unstructured search and combinatorial optimization problems. In an idealized setting, the asymptotic complexity analyses of these algorithms indicate computational speed-ups may be possible relative to state-of-the-art conventional methods. However, the presence of non-ideal conditions, including non-adiabatic dynamics, residual thermal excitations, and physical noise complicate the assessment of the potential computational performance. A relaxation of the adiabatic condition is captured in the complementary computational heuristic of quantum annealing, which accommodates physical systems operating at finite temperature and in open environments. While quantum annealing (QA) provides a more accurate model for the behavior of actual quantum physical systems, the possibility of non-adiabatic effects obscures a clear separation with conventional computing complexity.

A series of technological advances in the control of quantum physical systems have enabled experimental AQC and QA. Prominent examples include demonstrations using superconducting electronics, which encode quantum information in the magnetic flux induced by a weak current operating at cryogenic temperatures. A family of devices developed specifically for unconstrained optimization problems has been applied to solve problems in specific domains including logistics, finance, material science, machine learning, and numerical analysis. An accompanying infrastructure has also developed to support these experimental demonstrations and to enable access of a broader community of users. Although AQC is most commonly applied in superconducting technologies, alternative approaches include optically trapped neutral atoms and ion-trap systems.

The significant progress in the understanding of AQC has revealed several open topics that continue to motivate research into this model of quantum computation. Foremost is the development of methods for fault-tolerant operation that will ensure the scalability of AQC for solving large-scale problems. In addition, unequivocal experimental demonstrations that differentiate the computational power of AQC and its variants from conventional computing approaches are needed. This will also require advances in the fabrication and control of quantum physical systems under the adiabatic restrictions.
Technology and US Foreign Relations
Authors: Krysko Michael A.
Published: July 2019

Technology is ubiquitous in the history of US foreign relations. Throughout US history, technology has played an essential role in how a wide array of Americans have traveled to and from, learned about, understood, recorded and conveyed information about, and attempted to influence, benefit from, and exert power over other lands and peoples. The challenge for the historian is not to find where technology intersects with the history of US foreign relations, but how to place a focus on technology without falling prey to deterministic assumptions about the inevitability of the global power and influence—or lack thereof—the United States has exerted through the technology it has wielded.

“Foreign relations” and “technology” are, in fact, two terms with extraordinarily broad connotations. “Foreign relations” is not synonymous with “diplomacy,” but encompasses all aspects and arenas of American engagement with the world. “Technology” is itself “an unusually slippery term,” notes prominent technology historian David Nye, and can refer to simple tools, more complex machines, and even more complicated and expansive systems on which the functionality of many other innovations depends. Furthermore, processes of technological innovation, proliferation, and patterns of use are shaped by a dizzying array of influences embedded within the larger surrounding context, including but by no means limited to politics, economics, laws, culture, international exchanges, and environment. While some of the variables that have shaped how the United States has deployed its technological capacities were indeed distinctly American, others arose outside the United States and lay beyond any American ability to control. A technology-focused rendering of US foreign relations and global ascendancy is not, therefore, a narrative of uninterrupted progress and achievement, but an accounting of both successes and failures that illuminate how surrounding contexts and decisions have variably shaped, encouraged, and limited the technology and power Americans have wielded.
Canada-US Relations, 1759–2019
Authors: Bothwell Robert
Published: July 2019

Canada has sometimes been called the United States’ attic: a useful feature, but one easily forgotten. Of all countries, it has historically resembled the United States the most closely, in terms of culture, geography, economy, society, politics, ideology and, especially, history. A shared culture—literary, social, legal, and political—is a crucial factor in Canadian-American relations. Geography is at least as important. It provides the United States with strategic insulation to the north and enhances geographic isolation to the east and west. North-south economic links are inevitable and very large. It has been a major recipient of American investment, and for most of the time since 1920 has been the United States’ principal trading partner. Prosperous and self-sufficient, it has seldom required American aid. There have been no overtly hostile official encounters since the end of the War of 1812, partly because many Americans tended to believe that Canadians would join the republic; when that did not occur, the United States accepted an independent but friendly Canada as a permanent, useful, and desirable neighbor—North America’s attic. The insulation the attic provided was a common belief in the rule of law, both domestic and international; liberal democracy; a federal constitution; liberal capitalism; and liberal international trade regimes.

That said, the United States, with its large population, huge economy, and military power, insulates Canada from hostile external forces. An attack on Canada from outside the continent is hard to imagine without a simultaneous attack on the United States. Successive American and Canadian governments have reaffirmed the political status quo while favoring mutually beneficial economic and military linkages—bilateral and multilateral. Relations have traditionally been grounded in a negotiating style that is evidence-based, proceeding issue by issue. A sober diplomatic and political context sometimes frames irritations and exclamations, but even these have usually been defined and limited by familiarity. For example, there has always been anti-Americanism in Canada. Most often it consists of sentiments derived from the United States itself, channeled by cultural similarities. No American idea, good or bad, from liberalism to populism, fails to find an echo in Canada. How loud or how soft the echo makes the difference.
Civilian Nuclear Power
Authors: Pope Daniel
Published: July 2019

Nuclear power in the United States has had an uneven history and faces an uncertain future. Promising in the 1950s electricity “too cheap to meter,” nuclear power has failed to come close to that goal, although it has carved out approximately a 20 percent share of American electrical output. Two decades after World War II, General Electric and Westinghouse offered electric utilities completed “turnkey” plants at a fixed cost, hoping these “loss leaders” would create a demand for further projects. During the 1970s the industry boomed, but it also brought forth a large-scale protest movement. Since then, partly because of that movement and because of the drama of the 1979 Three Mile Island accident, nuclear power has plateaued, with only one reactor completed since 1995.

Several factors account for the failed promise of nuclear energy. Civilian power has never fully shaken its military ancestry or its connotations of weaponry and warfare. American reactor designs borrowed from nuclear submarines. Concerns about weapons proliferation stymied industry hopes for breeder reactors that would produce plutonium as a byproduct. Federal regulatory agencies dealing with civilian nuclear energy also have military roles. Those connections have provided some advantages to the industry, but they have also generated fears. Not surprisingly, the “anti-nukes” movement of the 1970s and 1980s was closely bound to movements for peace and disarmament.

The industry’s disappointments must also be understood in a wider energy context. Nuclear grew rapidly in the late 1960s and 1970s as domestic petroleum output shrank and environmental objections to coal came to the fore. At the same time, however, slowing economic growth and an emphasis on energy efficiency reduced demand for new power output. In the 21st century, new reactor designs and the perils of fossil-fuel-caused global warming have once again raised hopes for nuclear, but natural gas and renewables now compete favorably against new nuclear projects.

Economic factors have been the main reason that nuclear has stalled in the last forty years. Highly capital intensive, nuclear projects have all too often taken too long to build and cost far more than initially forecast. The lack of standard plant designs, the need for expensive safety and security measures, and the inherent complexity of nuclear technology have all contributed to nuclear power’s inability to make its case on cost persuasively. Nevertheless, nuclear power may survive and even thrive if the nation commits to curtailing fossil fuel use or if, as the Trump administration proposes, it opts for subsidies to keep reactors operating.
Australia, New Zealand, and the United States since World War II
Authors: Bell Roger
Published: July 2019

The war against Japan (1941–1945) gave rise to a uniquely enduring alliance between the United States, Australia, and New Zealand. Rooted in overlapping geopolitical interests and shared Western traditions, tripartite relationships forged in the struggles against fascism in World War II deepened as Cold War conflicts erupted in East and Southeast Asia. War in Korea drew the three Pacific democracies into a formal alliance, ANZUS. In the aftermath of defeat in Vietnam, however, American hegemony confronted new challenges, regionally and globally. A more fluid geopolitical environment replaced the alliance certainties of the early Cold War. ANZUS splintered but was not permanently broken. Thus the ebb and flow of tripartite relationships from the attack on Pearl Harbor to the first decades of the “Pacific Century” shifted as the “war on terror” and, in a very different way, the “rise of China,” revitalized trilateral cooperation and resuscitated the ANZUS agreement.
Gods in Ancient Greece and Rome
Authors: Dillon Matt
Published: July 2019

The religions of both the ancient Greeks and Romans were polytheistic (with many gods), but centered on a finite and homogenous group of deities who were worshipped through prayer, animal sacrifice, and festivals. It was believed that the gods, in turn, provided mortals with specific benefits, at the individual, family, group or state levels. Gods were anthropomorphic (in human form) and powerful but not eternal or all-powerful. New gods could be introduced into both pantheons (groups of gods), but the number of such additions was in fact fairly limited. And both Greeks and Romans concentrated on the cults of their traditional gods, whose worship they found both beneficial and satisfying for over one thousand years.
Daoist Mysticism
Authors: Murray Judson B.
Published: July 2019

Daoist mysticism is a subfield in academic areas of study including comparative mysticism, Chinese religions, and Daoist studies. Methodologies employed in it often adopt and adapt different definitions, categories, and theories formulated in contemporary Western scholarship on the subject of “mysticism” for the purpose of analyzing Daoist thinkers, texts, practices, and traditions throughout the religion’s history. Important topics examined in scholarly works on Daoist mysticism include, first, Daoist views of the human self, both as it exists in its problematic state of degeneracy—physically, intellectually, emotionally, and morally—and in the natural and optimal condition it can and should embody. A point of emphasis regarding the latter condition is the self’s experience or consciousness of, conformity to, and unity with that which is of ultimate significance for Daoists: the “Way” (Dao/Tao). Daoist mystics, by understanding themselves to be microcosmic embodiments of the world and its processes, grasp that they are inherent constituents of the Dao and are unified with the totality of existence that it encompasses. Second, there is an array of Daoist self-cultivation techniques that are combined into training regimens aimed at cultivating and actualizing this awareness. Methods range from practices relating to the optimal setting and lifestyle to adopt for training, proper preparation and maintenance of the body, qi/ch’i cultivation, ethical observances, visualizations, and other meditative techniques. Third, successful training in them achieves the mystical aims, experiences, and transformations that practitioners seek, including physical vigor to aid the body’s functioning and longevity, moral integrity, profound visions, true and omniscient insight, correct and effective conduct, self-divinization, and immortality. Fourth, the scholarship also identifies both notable continuities and intriguing innovations in comparing ancient Daoist mystical ideas, practices, and goals to later expressions and elaborations of them.

Studying Daoist mysticism has also reciprocally contributed to Western scholarly inquiries into theories of mysticism and comparative mysticism, not only in providing a wealth of material that is relevant to these fields, but also in offering both additional perspectives on debated issues and new trajectories for future research. For example, recent scholarship has contributed to the debate between, on the one hand, Essentialist and Decontextualist theorists and, on the other, Contextualists concerning the subject of mystical experience. Scholars of Daoist mysticism have also underscored the distinctiveness of the content and the literary form of its mystical writings, as well as the vital role the practitioner’s body plays in its theories and practices, and how these defining features distinguish Daoist mysticism from some of the world’s other mystical traditions.
Black Brotherhoods and Sisterhoods: Participatory Christianity in New Spain’s Mining Towns
Authors: von Germeten Nicole
Published: July 2019

Free and enslaved Africans played an important role in developing a unique form of participatory Christianity in New Spain’s mining towns, especially Zacatecas, San Luis Potosi, and Parral. Afro-Mexicans founded, organized, and led religious organizations, called cofradías, shaping them to their own needs and understandings of the sacred and its connections to social ties, gatherings, and celebrations. The practical goals of cofradías included helping sick members and paying for burials and funerals. Historians observe a kind of Latin American African-influenced Baroque piety in cofradías, with embodied practices concentrating on annual flagellant processions held during Holy Week, and an evolving internal gender dynamic, which suggests assimilative goals, even as cofradías strengthened Afro-Mexican communities.
US and the Cold War in Latin America
Authors: Field Jr. Thomas C.
Published: July 2019

The Cold War in Latin America had marked consequences for the region’s political and economic evolution. From the origins of US fears of Latin American Communism in the early 20th century to the collapse of the Soviet Union in the early 1990s, regional actors played central roles in the drama. Seeking to maximize economic benefit while maintaining independence with regard to foreign policy, Latin Americans employed an eclectic combination of liberal and anti-imperialist discourses, balancing frequent calls for anti-Communist hemispheric unity with periodic diplomatic entreaties to the Soviet bloc and the nonaligned Third World. Meanwhile, US Cold War policies toward the region ranged from progressive developmentalism to outright military invasions, and from psychological warfare to covert paramilitary action. Above all, the United States sought to shore up its allies and maintain the Western Hemisphere as a united front against extra-hemispheric ideologies and influence. The Cold War was a bloody, violent period for Latin America, but it was also one marked by heady idealism, courageous political action, and fresh narratives about Latin America’s role in the world, all of which continue to inform regional politics to this day.
Color and Race in Portuguese America, 1640–1750
Authors: Raminelli Ronald
Published: July 2019

Color and race are important references for assessing the privileges and barriers that sustained or impeded the social ascension of New Christians, Africans, Indians, and mestiços in the Portuguese world. Questions of race and color had profound links with the Catholic faith and with social exclusion, especially of Afro-descendants. The ideas of race and racism are not static, but were forged over time. Initially, they were strongly influenced by Catholicism and later were incorporated into the scientific knowledge of the 18th and 19th centuries. Therefore, the terms “race” and “racism,” based on 19th-century biological determinism, are not suitable for discussing social relations in the 17th and 18th centuries.
Digital Resources: The Trans-Atlantic Slave Trade Database
Authors: Eltis David
Published: July 2019

The Slavevoyages website completed ten years of successful operation in 2018. Drawing on four decades of archival research on five continents, a revolution in computer-processing costs, and the more recent explosive growth of the worldwide web, the site currently offers public access to several databases on slave trading in the Atlantic World. The two most important of these are first, a database of 36,000 slave-trading voyages between Africa and the New World, and second, a database of 11,400 voyages from one port in the Americas to another—a traffic known as the intra-American slave trade. The time span covered is from the 16th to the late 19th century. The site also offers personal information on 92,000 Africans found on board some of those voyages, which is stored in a separate database, as well as an interface that permits users to explore our estimates of the overall size and direction of the transatlantic slave trade broken down by each of the 340 years of its existence. In other words, the site attempts to allow for voyages for which information has not survived. The site currently averages over 1,000 visitors per day, who consult a mean of eight pages per visit. It was one of the first web-based databases to use crowdsourcing to correct existing information and attract new contributions to its core database. These are currently refreshed on an approximately annual basis and earlier versions are made available to users on a download page. Slavevoyages has become the basic reference tool for anyone studying the transatlantic slave trade, and is used widely by teachers, genealogists, and scientists as well as historians and, more specifically, scholars of slavery and the slave trade.
Observation of Aneurobracon philippinensis (Hymenoptera: Braconidae) Immatures Shows How Koinobiont Offspring Flexibly Adjust Their Development to Host Growth
Authors: Aoyama Haruka , Ohshima Issei
Published: July 2019

Koinobionts are parasitoids that allow their hosts to grow after infection, and they finally kill their host individuals at parasitoid-specific host stages. Since fatal accidents of host organisms directly result in the deaths of parasitizing koinobionts, a longer parasitization period in vulnerable hosts is likely to increase the mortality of the koinobionts. However, for hosts inhabiting concealed environments in their later developmental stages, koinobionts should begin parasitization in early-stage hosts to make use of the grown hosts. A koinobiont parasitoid, Aneurobracon philippinensis (Muesebeck), mainly uses a leaf-mining moth, Acrocercops transecta Meyrick (Lepidoptera: Gracillariidae) as a host. Due to the three-dimensional structure of the mines constructed by later instars of A. transecta, females of A. philippinensis seldomly oviposit into later instar hosts, whereas feeding on final instar hosts is essential for A. philippinensis larvae. This implies that oviposition targets in the wild are shifted to early instars, though the final instar is the ideal target to shorten the parasitization period. The dissection of wild host larvae demonstrated that no eggs were observed in the final instar, supporting the above expectation. Laboratory parasitization experiments revealed that A. philippinensis eggs hatched approximately 80 h after oviposition, and hatched larvae stayed in the first instar until the host larvae completed making cocoons. These results suggest that the first-instar period of the parasitoid larvae functions as an adjusting period to synchronize the parasitoid and host developmental stages and that koinobiosis plays an important role in utilizing the final instar of A. transecta as a resource.
H2FPEF Score as a Prognostic Value in HFpEF Patients
Authors: Sueta Daisuke , Yamamoto Eiichiro , Nishihara Taiki , Tokitsu Takanori , Fujisue Koichiro , Oike Fumi , Takae Masafumi , Usuku Hiroki , Takashio Seiji , Arima Yuichiro , Suzuki Satoru , Nakamura Taishi , Ito Miwa , Kanazawa Hisanori , Sakamoto Kenji , Kaikita Koichi , Tsujita Kenichi
Published: July 2019

Background

The H2FPEF score is recognized as a simple method to diagnose heart failure (HF) with preserved left ventricular ejection fraction (HFpEF). We investigated the value of the H2FPEF score in predicting subsequent cardiovascular events in HFpEF patients.

Methods

This study was a retrospective, single-center, observational study. We calculated the H2FPEF scores for 404 consecutive HFpEF patients. Subjects were subdivided into low- (0–3), intermediate- (4–6), and high-score (7–9) groups and followed for 50 months. The primary and secondary endpoints were composite cardiovascular/cerebrovascular events (cardiovascular death, nonfatal myocardial infarction, unstable angina pectoris, hospitalization for HF decompensation, and nonfatal stroke) occurrence and HF-related events (hospitalization for HF decompensation) occurrence at 50 months, respectively.

Results

Kaplan–Meier analyses demonstrated a significantly higher incidence of cardiovascular/cerebrovascular events among those with a higher H2FPEF score (log-rank test, P = 0.005). The HF-related event rate was higher in proportion to the H2FPEF score (log-rank test, P < 0.001). Multivariate Cox hazard analyses identified the H2FPEF score (per 1 point) as an independent predictor of cardiovascular and HF-related events (hazard ratio [HR], 1.179; 95% confidence interval [CI], 1.066–1.305; P = 0.001 and HR, 1.288; 95% CI, 1.134–1.463; P = 0.001, respectively). Receiver operating characteristic analysis showed that the H2FPEF significantly predicted cardiovascular events (area under the curve [AUC], 0.626; 95% CI, 0.557–0.693; P < 0.001) and HF-related events (AUC, 0.680; 95% CI, 0.600–0.759; P < 0.001). The cutoff H2FPEF score was 5.5 for the identification of cardiovascular and HF-related events.

Conclusion

The H2FPEF score might be a potentially useful marker for the prediction of cardiovascular and HF-related events in HFpEF patients.

Clinical Trails Registration

Trail Number UMIN000029600.
Evaluation of the Vertical Movement of Ribeiro’s Dermolipoglandular Mammary Flap One Year After Mammaplasties in Post-Bariatric Patients
Authors: Sizenando Rodrigo P , Diniz Marco Túlio C , da Costa Paulo Roberto , Manhães Luiz Gustavo S
Published: July 2019

Background

In 1971, Ribeiro isolated a segment in the inferior pole of the ptotic breast, nourished by muscular perforating vessels, and moved it cranially to the posterior region of the remaining detached breast tissue, where it was fixed to the pectoral fascia. This maneuver created a flap with autologous implant function, independent from the rest of the breast’s support, that maintained long-term mammary projection.

Objectives

The objectives of this study were to measure the vertical movement of this flap 1 year after mammaplasty and to evaluate the factors involved.

Methods

The sample included 13 patients who had previously undergone bariatric surgery. The position of a titanium marker attached to the Ribeiro flap was compared on chest radiographs taken 1 day and 1 year after the mammaplasty. The significance level was set at 5%.

Results

All of the titanium markers moved 0.6 cm to 4.1 cm caudally during the study period (average, 2.4 cm ± 1.02 cm). The greater the weight loss after the plastic surgery, the further the marker’s descent. Weight loss between bariatric surgery and plastic surgery, the vertical dimension of the ptotic breast tissue immediately before plastic surgery, the vertical extent of the nipple-areola complex elevation during mammaplasty, the Ribeiro flap thickness and volume, and the breast volume after mammaplasty were not associated with the vertical movement of the flap.

Conclusions

The Ribeiro flap employed in mammaplasty of patients who previously underwent bariatric surgery undergoes ptosis that is exacerbated by weight loss after mammaplasty.

Level of Evidence: 4
Gene set analysis methods for the functional interpretation of non-mRNA data—Genomic range and ncRNA data
Authors: Mora Antonio
Published: July 2019

Gene set analysis (GSA) is one of the methods of choice for analyzing the results of current omics studies; however, it has been mainly developed to analyze mRNA (microarray, RNA-Seq) data. The following review includes an update regarding general methods and resources for GSA and then emphasizes GSA methods and tools for non-mRNA omics datasets, specifically genomic range data (ChIP-Seq, SNP and methylation) and ncRNA data (miRNAs, lncRNAs and others). In the end, the state of the GSA field for non-mRNA datasets is discussed, and some current challenges and trends are highlighted, especially the use of network approaches to face complexity issues.
Effect of Mobile Phase pH on the Electrospray Ionization Efficiency and Qualitative Analysis of Pharmaceuticals in ESI + LC-MS/MS
Authors: Kafeenah Husam I S , Osman Rozita , Bakar N K A
Published: July 2019

The effect of mobile phase pH on positive ionization process and retention time of nine pharmaceuticals on ultra-performance liquid chromatography-electrospray–tandem mass spectrometry (LC-MS/MS) was discussed. The effective use of high and low mobile phase pH in LC-MS/MS qualitative analyses method was also evaluated by comparing the instrument detection limit, quantification limit, precision, linearity and signal to noise (S/N) under low and high mobile phase pH. In this work, six mobile phase pH that ranged between pH 2 and pH 10 were used to evaluate the effect of the mobile phase pH changes on the ionization process in electrospray ionization. Results revealed that high mobile phase pH ionized more pharmaceuticals molecules and gave a higher signal than low mobile phase pH in positive ionization mode. The results proved that ammonium ion was better as a proton donor in high pH mobile phase than the hydronium ion in acidic mobile phase. The results revealed that the qualitative LC-MS/MS analyses method by using high mobile phase pH has better performance for most analytes in terms of sensitivity, precision, linearity and S/N than the low mobile phase pH.
The impact of aortic valve replacement on survival in patients with normal flow low gradient severe aortic stenosis: a propensity-matched comparison
Authors: Saeed Sahrai , Vamvakidou Anastasia , Seifert Reinhard , Khattar Rajdeep , Li Wei , Senior Roxy
Published: July 2019

Aims

To assess the survival benefit of aortic valve replacement (AVR) in patients with normal flow low gradient severe aortic stenosis (AS).

Methods and results

A retrospective study of prospectively collected data of 276 patients (mean age 75 ± 15 years, 51% male) with normal transaortic flow [flow rate (FR) ≥200 mL/s or stroke volume index (SVi) ≥35 mL/m2] and severe AS (aortic valve area <1.0 cm2). The outcome measure was all-cause mortality. Of the 276 patients, 151 (55%) were medically treated, while 125 (45%) underwent an AVR. Over a mean follow-up of 3.2 ± 1.8 years (range 0–6.9 years), a total of 96 (34.8%) deaths occurred: 17 (13.6%) in AVR group vs. 79 (52.3%) in those medically treated, when transaortic flow was defined by FR (P < 0.001). When transaortic flow was defined by SVi, a total of 79 (31.3%) deaths occurred: 18 (15.1%) in AVR group vs. 61 (45.9%) in medically treated (P < 0.001). In a propensity-matched multivariable Cox regression analysis adjusting for age, gender, body surface area, smoking, hypertension, diabetes mellitus, atrial fibrillation, peripheral vascular disease, chronic kidney disease, left ventricular ejection fraction, left ventricular mass, and mean aortic gradient, not having AVR was associated with a 6.3-fold higher hazard ratio (HR) of all-cause mortality [HR 6.28, 95% confidence interval (CI) 3.34–13.16; P < 0.001] when flow was defined by FR. In the SVi-guided model, it was 3.83-fold (HR 3.83, 95% CI 2.30–6.37; P < 0.001).

Conclusion

In patients with normal flow low gradient severe AS, AVR was associated with a significantly improved survival compared with those who received standard medical treatment.
Strain-oriented strategy for guiding cardioprotection initiation of breast cancer patients experiencing cardiac dysfunction
Authors: Santoro Ciro , Esposito Roberta , Lembo Maria , Sorrentino Regina , De Santo Irene , Luciano Federica , Casciano Ofelia , Giuliano Mario , De Placido Sabino , Trimarco Bruno , Lancellotti Patrizio , Arpino Grazia , Galderisi Maurizio
Published: July 2019

Aims

This study assessed the impact of the strain-guided therapeutic approach on cancer therapy-related cardiac dysfunction (CTRCD) and rate of cancer therapy (CT) interruption in breast cancer.

Methods and results

We enrolled 116 consecutive female patients with HER2-positive breast cancer undergoing a standard protocol by EC (epirubicine + cyclophosphamide) followed by paclitaxel + trastuzumab (TRZ). Coronary artery, valvular and congenital heart disease, heart failure, primary cardiomyopathies, permanent or persistent atrial fibrillation, and inadequate echo-imaging were exclusion criteria. Patients underwent an echo-Doppler exam with determination of ejection fraction (EF) and global longitudinal strain (GLS) at baseline and every 3 months during CT. All patients developing subclinical (GLS drop >15%) or overt CTRCD (EF reduction <50%) initiated cardiac treatment (ramipril+ carvedilol). In the 99.1% (115/116) of patients successfully completing CT, GLS and EF were significantly reduced and E/e′ ratio increased at therapy completion. Combined subclinical and overt CTRCD was diagnosed in 27 patients (23.3%), 8 at the end of EC and 19 during TRZ courses. Of these, 4 (3.4%) developed subsequent overt CTRCD and interrupted CT. By cardiac treatment, complete EF recovery was observed in two of these patients and partial recovery in one. These patients with EF recovery re-started and successfully completed CT. The remaining patient, not showing EF increase, permanently stopped CT. The other 23 patients with subclinical CTRCD continued and completed CT.

Conclusion

These findings highlight the usefulness of ‘strain oriented’ approach in reducing the rate of overt CTRCD and CT interruption by a timely cardioprotective treatment initiation.
Social mobility, accumulation of disadvantages and health. An analysis with retrospective data from the GSOEP (2002–14)
Authors: Knöchelmann Anja , Günther Sebastian , Moor Irene , Seifert Nico , Richter Matthias
Published: July 2019

Background

Socioeconomic position (SEP) in different life stages is related to health-related quality of life (HRQoL). Yet, research on the relevance of life course processes is scarce. This study aims to analyse the association between accumulation of disadvantages, social mobility and HRQoL.

Methods

Analyses were conducted using population-averaged panel-data models and are based on data from the German Socio-Economic Panel 2002–14, including retrospective biographical information, comprising 25 473 observations from 8666 persons. Intergenerational and intragenerational mobility included the occupational positions in childhood (parental position), first job and middle age. Accumulation of disadvantages was measured using an accumulation index. HRQoL was assessed using the Mental and Physical Component Summary Scores of the SF12v2.

Results

Accumulation of disadvantages was the main predictor for the Physical Component Summary in mid-age. Men and women in a stable low SEP or with a steep downward mobility showed the least favourable physical HRQoL. This holds for intergenerational and intragenerational mobility. Mental HRQoL did not seem to be associated with accumulation or social mobility.

Conclusion

The results show that physical HRQoL is related to social mobility and accumulation of (dis-)advantages. Further research is needed thoroughly analysing this association.
Time-varying probabilities of earthquake occurrence in central New Zealand based on the EEPAS model compensated for time-lag
Authors: Rhoades David A , Christophersen Annemarie
Published: July 2019

The ‘Every Earthquake a Precursor According to Scale’ (EEPAS) model treats every earthquake as a precursor of larger earthquakes to follow it within a time-span ranging from months to decades, depending on magnitude. Each earthquake contributes a transient increment to the expected rate of earthquake occurrence in its vicinity, based on empirical predictive scaling relations associated with the precursory scale increase phenomenon. Incomplete information on precursory earthquakes causes the EEPAS model to underpredict the expected number of earthquakes, in particular when forecasting across a time-lag for periods beginning several years ahead. We demonstrate how the model can be modified to compensate for such time-lags when calculating future forecasts. Given the model parameters, the completeness of precursory information can be expressed as a function of the target earthquake magnitude and the time-lag. We consider two end-members for compensating the model for incompleteness. In one end-member, only the background smoothed-seismicity component of the EEPAS model is compensated, in the other, only the time-varying component of the EEPAS model is compensated. We estimate an optimal mixture of these two end-members for time-lags out to 12 yr, using several different versions of the EEPAS model and subsets of the New Zealand earthquake catalogue to which the models were previously fitted. Performance is checked on an independent test period. The optimal compensated model has increasingly high information gains over the original EEPAS model with increasing time-lags. Using catalogue data complete to 2018, the compensated models forecast increased annual probabilities of earthquake occurrence above magnitude thresholds from 6.0 to 8.0 in central New Zealand in the period 2019–2030 relative to the preceding period 2008–2018.
On the forward modelling of three-dimensional magnetotelluric data using a radial-basis-function-based mesh-free method
Authors: Long Jianbo , Farquharson Colin G
Published: July 2019

The investigation of using a novel radial-basis-function-based mesh-free method for forward modelling magnetotelluric data is presented. The mesh-free method, which can be termed as radial-basis-function-based finite difference (RBF-FD), uses only a cloud of unconnected points to obtain the numerical solution throughout the computational domain. Unlike mesh-based numerical methods (e.g. grid-based finite difference, finite volume and finite element), the mesh-free method has the unique feature that the discretization of the conductivity model can be decoupled from the discretization used for numerical computation, thus avoiding traditional expensive mesh generation and allowing complicated geometries of the model be easily represented. To accelerate the computation, unstructured point discretization with local refinements is employed. Maxwell’s equations in the frequency domain are re-formulated using $\mathbf {A}$-ψ potentials in conjunction with the Coulomb gauge condition, and are solved numerically with a direct solver to obtain magnetotelluric responses. A major obstacle in applying common mesh-free methods in modelling geophysical electromagnetic data is that they are incapable of reproducing discontinuous fields such as the discontinuous electric field over conductivity jumps, causing spurious solutions. The occurrence of spurious, or non-physical, solutions when applying standard mesh-free methods is removed here by proposing a novel mixed scheme of the RBF-FD and a Galerkin-type weak-form treatment in discretizing the equations. The RBF-FD is applied to the points in uniform conductivity regions, whereas the weak-form treatment is introduced to points located on the interfaces separating different homogeneous conductivity regions. The effectiveness of the proposed mesh-free method is validated with two numerical examples of modelling the magnetotelluric responses over 3-D conductivity models.
At-scale evidence from 26 national household surveys on the prevention of mother-to-child transmission of HIV cascade
Authors: Wilson Nicholas
Published: July 2019

Prevention of mother-to-child transmission of HIV (PMTCT) can virtually eliminate vertical HIV transmission, yet more than 160 000 children were newly infected with HIV in 2016. We conducted a pooled analysis of national household surveys from 26 sub-Saharan African countries and calculated PMTCT coverage and access using unconditional and conditional likelihoods. Logistic regression analysis adjusted for country of residence was used to measure the association between socio-demographic factors and PMTCT coverage. The largest loss in the PMTCT cascade access occurred at being offered a HIV test at an antenatal care (ANC) clinic visit, with only 62.6% of women visiting an ANC clinic being offered a HIV test. Logistic regression analysis adjusted for country of residence indicated that completing primary school was associated with a higher likelihood of completing each step in the PMTCT cascade, including being offered a HIV test [odds ratio 2.18 (95% CI: 2.09–2.26)]. Urban residence was associated with a higher likelihood of completing each step in the PMTCT cascade, including being offered a HIV test [odds ratio 2.23 (95% CI: 2.15–2.30)]. To increase progression through the PMTCT cascade, policy-makers should target the likelihood an ANC client is offered a HIV test and the likelihood of facility delivery, steps where access is the lowest. Low educational attainment women and women in rural areas appear to have the lowest coverage in the cascade, suggesting that policy-makers target these individuals.
Interrogating dialogic theories of judicial review
Authors: Jhaveri Swati
Published: July 2019

This article critically evaluates dialogic theories of judicial review. It focuses on three main criticisms. Dialogic theories of judicial review can be criticised for being overinclusive in their application to vastly different constitutional systems; overenthusiastic in their preference for weak forms of judicial review; and overly positive in their characterization of systems as “dialogic,” ignoring the existence of interbranch conflict and instances of negative exchanges. This article contributes to this critical conversation on dialogic theories in the context of Asia, specifically Singapore and India. Recent attempts to justify these systems as “dialogic” exemplify these criticisms. The problem of overinclusiveness is easily apparent given that Singapore and India are examples of, respectively, weak and strong forms of judicial review in the common law world. The eagerness to extend dialogic analyses to such vastly different systems leads to problems. The enthusiasm to justify Singapore’s weak-form review as dialogic can potentially lead to a slowed-down advance on constitutionalism. The optimistic vision of constitutional amendments by the political branches in India following judicial review proceedings as a tool for interbranch exchange ignores the combative and tense constitutional conversations surrounding such amendments.
Stochastic boundedness of state trajectories of stable LTI systems in the presence of non-vanishing stochastic perturbation
Authors: Azodi Peyman , Setoodeh Peyman , Khayatian Alireza , Jamalinia Elham
Published: July 2019

This paper studies stochastic boundedness of trajectories of a non-vanishing stochastically perturbed stable linear time-invariant system. First, two definitions on stochastic boundedness are presented, then, the boundedness is analyzed via Lyapunov theory. A theorem is proposed, which shows that under a condition on the Lipchitz constant of the perturbation kernel, the trajectories remain stochastically bounded, and the bounds are calculated. Also, the limiting behaviour of the trajectories is studied. At the end, an illustrative example is presented, which shows the effectiveness of the proposed theory.