bluuebunny/crossref_metadata_2025 huggingface dataset:
Is Identification of Lupus Erythematosus Cells Still Useful? A Case Report
Authors: Xu Min , Macneal Lucinda A. , Wittman Brenda J. , Rutledge Joe C.
Published: November 2015

A 13-year-old girl presented with significant weight loss, depression, anemia, and neutropenia. The preliminary diagnosis was anorexia nervosa combined with depression. Due to peripheral cytopenia, a bone marrow biopsy was performed to rule out leukemia. Lupus erythematosus (LE) cells were found in the bone marrow aspirate, which prompted autoantibody testing, although clinically it was not suspected the patient had systemic lupus erythematosus (SLE). Further testing demonstrated very high levels of antinuclear antibodies (ANA) (>12 U) and anti–double strand DNA (dsNDA) (>1000 IU/mL), which confirmed the diagnosis of SLE. The patient was treated with steroids for SLE, and symptoms improved quickly. In conclusion, although the identification of LE cells as one of the diagnostic criteria for SLE has been obsolete, careful examination of bone marrow to identify LE cells is still very important in the diagnosis of unsuspected SLE.
The lure and the limits of dialogue
Authors: Kavanagh Aileen
Published: November 2015

Over the last two decades, the metaphor of ‘dialogue’ has become a common way of characterizing the relationship between courts and legislatures under bills of rights. Following an examination of the role of ‘dialogue’ in debates about the Canadian Charter and the UK Human Rights Act, this article will argue that dialogue is a misleading metaphor, which we should abandon in our constitutional discourse. While it may have contributed some potential insights, its overall effect has been to distort our understanding of the relationship between courts and legislatures under bills of rights. In the scholarly debates surrounding dialogue, the lure of the metaphor obscured its limits. This article examines some of the pathologies which afflicted the debate about dialogue in comparative constitutional discourse, detailing some of the many distortions of dialogue.
The 1980s and Present in Maribor -- Creativity and Déjà Vu
Authors: Kordiš Meta
Published: November 2015

The article discusses the process of setting up an exhibition presenting the fragments of alternative creative practices in 1980s Maribor (Slovenia) in an art museum. Within an interdisciplinary approach – art historical, museological and anthropological, which is in focus here – I try to understand how such a heritage of alternative creative practices is constructed and produced. Furthermore, the question of the anthropological potentiality of exhibition-making as a method for researching certain aspects of urban practices and development is considered. During the exhibition the art museum became a collaborative place for negotiating, mediating and constructing a heritage between an imagined community of (once) alternative individuals and collectives who participated in the exhibition, the museum staff, visitors and the media. The exhibition was echoed in some other events in the city as it also addressed contemporary artistic, cultural and social issues in Maribor.
Natalie 2.0: Sparse Global Network Alignment as a Special Case of Quadratic Assignment
Authors: El-Kebir Mohammed , Heringa Jaap , Klau Gunnar
Published: November 2015

Data on molecular interactions is increasing at a tremendous pace, while the development of solid methods for analyzing this network data is still lagging behind. This holds in particular for the field of comparative network analysis, where one wants to identify commonalities between biological networks. Since biological functionality primarily operates at the network level, there is a clear need for topology-aware comparison methods. We present a method for global network alignment that is fast and robust and can flexibly deal with various scoring schemes taking both node-to-node correspondences as well as network topologies into account. We exploit that network alignment is a special case of the well-studied quadratic assignment problem (QAP). We focus on sparse network alignment, where each node can be mapped only to a typically small subset of nodes in the other network. This corresponds to a QAP instance with a symmetric and sparse weight matrix. We obtain strong upper and lower bounds for the problem by improving a Lagrangian relaxation approach and introduce the open source software tool Natalie 2.0, a publicly available implementation of our method. In an extensive computational study on protein interaction networks for six different species, we find that our new method outperforms alternative established and recent state-of-the-art methods.
Evaluation of Precipitation Climatology Derived from TRMM Multi-Satellite Precipitation Analysis (TMPA) Monthly Product over Land with Two Gauge-Based Products
Authors: Liu Zhong
Published: November 2015

The NASA/JAXA Tropical Rainfall Measuring Mission (TRMM) has been in operation for over 17 years since 1997. The length of TRMM is far shorter than those from ground observations, raising a question as to whether TRMM derived climatology products are good enough for research and applications. In this study, three climatologies derived from a blended product (the TRMM Multi-Satellite Precipitation Analysis (TMPA) monthly product or 3B43) and gauge-based ground observations (Global Precipitation Climatology Center (GPCC) and Willmott and Matsuura (WM)) are compared over land on a global scale (50° N–50° S) to assess the performance and weaknesses of the TMPA-derived climatology. Results show that the 3B43 climatology matches well with the two gauge-based climatologies in all seasons in terms of spatial distribution, zonal means as well as seasonal variations. However, large variations are found in light rain (<0.5 mm/day) regions such as the Sahara Desert. At high rain rates, large negative biases (3B43 < WM < GPCC) are found in orographically influenced regions such as windward sides of monsoon mountains in JJA, which is associated with underestimation of shallow orographic rain rates in microwave radiometer algorithms and sparse gauge data for bias correction. Nonetheless, biases in 3B43 exist and vary with geographic locations due to a number of factors such as gauge availability and algorithm issues.
Identification of Candidate Genes for Seed Glucosinolate Content Using Association Mapping in Brassica napus L.
Authors: Qu Cun-Min , Li Shi-Meng , Duan Xiu-Jian , Fan Jin-Hua , Jia Le-Dong , Zhao Hui-Yan , Lu Kun , Li Jia-Na , Xu Xin-Fu , Wang Rui
Published: November 2015

Rapeseed contains glucosinolates, a toxic group of sulfur-containing glucosides, which play critical roles in defense against herbivores and microbes. However, the presence of glucosinolates in rapeseed reduces the value of the meal as feed for livestock. We performed association mapping of seed glucosinolate (GS) content using the 60K Brassica Infinium single nucleotide polymorphism (SNP) array in 520 oilseed rape accessions. A total of 11 peak SNPs significantly associated with GS content were detected in growing seasons of 2013 and 2014 and were located on B. napus chromosomes A08, A09, C03, and C09, respectively. Two associated regions of GS content covered by these markers were further verified, and three B. napus homologous genes involved in the biosynthesis and accumulation of GS were identified. These genes were multigene family members and were distributed on different chromosomes. Moreover, two genes (BnGRT2 and BnMYB28) associated with GS content were validated by the qRT-PCR analysis of their expression profiles. The further identification and functionalization of these genes will provide useful insight into the mechanism underlying GS biosynthesis and allocation in B. napus, and the associated SNPs markers could be helpful for molecular maker-assisted breeding for low seed GS in B. napus.
A Critical Role for Cysteine 57 in the Biological Functions of Selenium Binding Protein-1
Authors: Ying Qi , Ansong Emmanuel , Diamond Alan , Yang Wancai
Published: November 2015

The concentration of selenium-binding protein1 (SBP1) is often lower in tumors than in the corresponding tissue and lower levels have been associated with poor clinical outcomes. SBP1 binds tightly selenium although what role selenium plays in its biological functions remains unknown. Previous studies indicated that cysteine 57 is the most likely candidate amino acid for selenium binding. In order to investigate the role of cysteine 57 in SBP1, this amino acid was altered to a glycine and the mutated protein was expressed in human cancer cells. The SBP1 half-life, as well as the cellular response to selenite cytotoxicity, was altered by this change. The ectopic expression of SBP1GLY also caused mitochondrial damage in HCT116 cells. Taken together, these results indicated that cysteine 57 is a critical determinant of SBP1 function and may play a significant role in mitochondrial function.
Leptin Promotes cPLA2 Gene Expression through Activation of the MAPK/NF-κB/p300 Cascade
Authors: Hsu Pei-Sung , Wu Chi-Sheng , Chang Jia-Feng , Lin Wei-Ning
Published: November 2015

Hyperplasia or hypertrophy of adipose tissues plays a crucial role in obesity, which is accompanied by the release of leptin. Recently, obesity was determined to be associated with various pulmonary diseases including asthma, acute lung injury, and chronic obstructive pulmonary disease. However, how obesity contributes to pulmonary diseases and whether leptin directly regulates lung inflammation remains unclear. We used cell and animal models to study the mechanisms of leptin mediation of pulmonary inflammation. We found that leptin activated de novo synthesis of cytosolic phospholipase A2-α (cPLA2-α) in vitro in the lung alveolar type II cells, A549, and in vivo in ICR mice. Upregulated cPLA2-α protein was attenuated by pretreatment with an OB-R blocking antibody, U0126, SB202190, SP600125, Bay11-7086, garcinol, and p300 siRNA, suggesting roles of p42/p44 MAPK, p38 MAPK, JNK1/2, NF-κB, and p300 in leptin effects. Leptin enhanced the activities of p42/p44 MAPK, p38 MAPK, JNK1/2, and p65 NF-κB in a time-dependent manner. Additional studies have suggested the participation of OB-R, p42/p44 MAPK, and JNK1/2 in leptin-increased p65 phosphorylation. Furthermore, p300 phosphorylation and histone H4 acetylation were reduced by blockage of OB-R, p42/p44 MAPK, p38 MAPK, JNK1/2, and NF-κB in leptin-stimulated cells. Similarly, blockage of the MAPKs/NF-κB/p300 cascade significantly inhibited leptin-mediated cPLA2-α mRNA expression. Our data as a whole showed that leptin contributed to lung cPLA2-α expression through OB-R-dependent activation of the MAPKs/NF-κB/p300 cascade.
Gold-Coated Superparamagnetic Nanoparticles for Single Methyl Discrimination in DNA Aptamers
Authors: Tintoré Maria , Mazzini Stefania , Polito Laura , Marelli Marcello , Latorre Alfonso , Somoza Álvaro , Aviñó Anna , Fàbrega Carme , Eritja Ramon
Published: November 2015

Au- and iron-based magnetic nanoparticles (NPs) are promising NPs for biomedical applications due to their unique properties. The combination of a gold coating over a magnetic core puts together the benefits from adding the magnetic properties to the robust chemistry provided by the thiol functionalization of gold. Here, the use of Au-coated magnetic NPs for molecular detection of a single methylation in DNA aptamer is described. Binding of α-thrombin to two aptamers conjugated to these NPs causes aggregation, a phenomenon that can be observed by UV, DLS and MRI. These techniques discriminate a single methylation in one of the aptamers, preventing aggregation due to the inability of α-thrombin to recognize it. A parallel study with gold and ferromagnetic NPs is detailed, concluding that the Au coating of FexOy NP does not affect their performance and that they are suitable as complex biosensors. These results prove the high detection potency of Au-coated SPIONs for biomedical applications especially for DNA repair detection.
Improvement of Psychotic Symptoms and the Role of Tissue Plasminogen Activator
Authors: Hoirisch-Clapauch Silvia , Nardi Antonio
Published: November 2015

Tissue plasminogen activator (tPA) mediates a number of processes that are pivotal for synaptogenesis and remodeling of synapses, including proteolysis of the brain extracellular matrix, degradation of adhesion molecules, activation of neurotrophins, and activation of the N-methyl-d-aspartate receptor. Abnormalities in these processes have been consistently described in psychotic disorders. In this paper, we review the physiological roles of tPA, focusing on conditions characterized by low tPA activity, which are prevalent in schizophrenia. We then describe how tPA activity is influenced by lifestyle interventions and nutritional supplements that may ameliorate psychotic symptoms. Next, we analyze the role of tPA in the mechanism of action of hormones and medications effective in mitigating psychotic symptoms, such as pregnenolone, estrogen, oxytocin, dopamine D3 receptor antagonists, retinoic acid, valproic acid, cannabidiol, sodium nitroprusside, N-acetyl cysteine, and warfarin. We also review evidence that tPA participates in the mechanism by which electroconvulsive therapy and cigarette smoking may reduce psychotic symptoms.
Analysis of the Constituents in “Zhu She Yong Xue Shuan Tong” by Ultra High Performance Liquid Chromatography with Quadrupole Time-of-Flight Mass Spectrometry Combined with Preparative High Performance Liquid Chromatography
Authors: Wang Lin-Lin , Han Li-Feng , Yu He-Shui , Sang Mang-Mang , Liu Er-Wei , Zhang Yi , Fang Shi-Ming , Wang Tao , Gao Xiu-Mei
Published: November 2015

“Zhu She Yong Xue Shuan Tong” lyophilized powder (ZSYXST), consists of a series of saponins extracted from Panax notoginseng, which has been widely used in China for the treatment of strokes. In this study, an ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) combined with preparative high performance liquid chromatography (PHPLC) method was developed to rapidly identify both major and minor saponins in ZSYXST. Some high content components were removed through PHPLC in order to increase the sensitivity of the trace saponins. Then, specific characteristic fragment ions in both positive and negative mode were utilized to determine the types of aglycone, saccharide, as well as the saccharide chain linkages. As a result, 94 saponins, including 20 pairs of isomers and ten new compounds, which could represent higher than 98% components in ZSYXST, were identified or tentatively identified in commercial ZSYXST samples.
La nouvelle notoriété : quelle place pour le généalogiste ?
Authors: Labelle-Pichevin Fabienne
Published: November 2015

La loi n° 2001-1135 du 3 décembre 2001, portant réforme du droit des successions, a institutionnalisé la pratique de l'acte de notoriété. En posant les nouvelles conditions de l'acte, et notamment, en décrivant son contenu obligatoire, elle n'en modifie pas substantiellement les effets. En revanche, elle accroît la responsabilité du notaire chargé de sa rédaction et augure sans doute un nouveau partenariat avec les généalogistes.
Banque et crédit à Lille de 1800 à 1939
Authors: Pouchain Pierre
Published: November 2015

Lille, an industrial centre witnesses only belatedly the creation of an organised banking network. This latter grows only after 1848 with the establishment of numerous regional banks ; the major national institutions establish themselves in 1865 and 1881. After several years of hardship, most of these companies enjoy an exceptional prosperity between the end of the XIXth century and 1914.

The war over, business conditions have changed. Financial crashes foreign to the city and the lasting depression generate a period of instability, at the end of which the picture of the Lille banking world is durably altered.
L'épuration des Magistrats du Nord en 1883
Authors: Martinage Renée
Published: November 2015

Sixteen irremovabe magistrates feel victim of the 1883 Republican purge in the Nord and Pas-de-Calais. The eviction hit more severely the hierarchy in our region than in the rest of the territory.

Judicial notabilities, rich, in their mid-fifties, with distinguished social origins, Catholic, close to the older powers, were thus eliminated by the Republicans in order to weaken the local dynasties.

Yet political motivations were preeminent in the choice of those excluded from the magistracy. Faithful servants of the previous regimes, they all had demonstrated their hostility to the Republic, mostly when the 1880 anti-religious decrees were published. Their professional quality, though quite high, was not taken into account.

In other words, in the Nord, the Republic chose to make examples.
La formation d'un homme politique Maurice Schumann de 1911 à 1940
Authors: Michau François-Xavier
Published: November 2015

Born in april 1911 , in a family of the Paris upper middleclass, son of a liberal Israelitish father, Maurice Schumann progressively converted himself to the Christian faith, but delayed his christening until 1942 out of solidarity for the persecuted Jewish European community. Revolted by social injustice, he was amember of the S.F.I.O. from 1928 to 1935, when he breaks his ties with that party to join the Jeune Républicaine, founded by Marc Sangnier. The Jeune République enables him better to reconciliate his yearning for social advances with his genuinely Catholic faith. Moreover, the Jeune République is also a real Gaullist before its time spiritual family (with Philippe Serre, André Lecomte). Schumann, a man endowed with a vast culture (he renounced a university career in favour of great reporting), but also a man of contact, was thus to meet Colonel de Gaulle as early as before the war, at a dinner at Daniel Rops's.

A specialist of international relations, Schumann was to demonstrate, through numerous articles and books (the most famous of which remains Le Germanisme en marche, in 1938) a lot of acumen, warn against Nazi pan-germanism, worry about the policy of the U.S.S.R., and also of Italy, in these years (1936-1939) of progress towards war. His reflexions were to bring M. Schumann to join De Gaulle, as early as June 1940, in London.
Pregnancy in a Renal Transplant Recipient with HIV-1 Infection: A Case Report
Authors: Agüero Fernando , Cofan Frederic , Fortuny Claudia , Lopez Marta , Manzardo Christian , Lonca Montserrat , Oppenheimer Frederic , Moreno Asuncion , Campistol Josep M , Miro Jose M
Published: November 2015

We report the first case of a pregnancy in a renal transplant recipient with HIV infection. She underwent renal transplantation in 2005 and became pregnant in 2009. The patient underwent vaginal delivery and a healthy full-term, female baby was born. Almost 6 years after delivery, both mother and child were doing well. The management of concurrent renal transplantation, HIV infection and pregnancy was extremely challenging. Women with HIV infection who have undergone renal transplantation should be accurately informed of the potential health risks for them and their offspring. Multidisciplinary teams are mandatory in order to properly manage these patients.
A stochastic approach to rhotic variation in Spanish codas
Authors: Gibson Mark
Published: November 2015

A stochastic analysis using aerodynamic and temporal variables is presented to explain tap/trill variation in Spanish codas. Simultaneous intraoral pressure (Po), translingual flow (F) and acoustic signals were obtained for two native speakers of Peninsular Spanish performing a rate-controlled reiterative task. Data were analyzed using linear mixed effects models fitted with random effects for speaker and repetition. The results show that tongue height and tongue anteriority of the preceding vowel affect the timing and aerodynamic parameters of the rhotic onset gesture, but the phonological specifications of the following consonants do not. Continuous variables were fit into a Bayesian logit regression model using noninformative priors which shows that tap/trill variation in coda can be predicted in part from aerodynamic and temporal parameters. Such a proposal obviates the need to resort to positional constraints to explain tap/trill variation in codas.
STP-ISS Transport Protocol for SpaceWire On-Board Networks
Authors: Olenev Valentin , Lavrovskaya Irina , Sheynin Yuriy , Korobkov Ilya , Suvorova Elena , Podgornova Elena , Dymov Dmitry , Kochura Sergey
Published: November 2015

The paper describes the development of a new transport protocol for the SpaceWire onboard networks. It starts from the overview and analysis of existing SpaceWire-oriented transport protocols. Then the paper considers the general industrial requirements for the Transport protocol, which should operate over the SpaceWire network technology. The main two chapters of the paper present the first and the second revisions of the new STP-ISS transport protocol, which has been developed in accordance with the results of the overview and technical requirements. In addition, the authors describe STP-ISS modeling process, which was very efficient for the STP ISS protocol development, testing, analysis and improvement.
Archean basement underlying Paleoproterozoic Cape Smith Belt: part of Povungnituk map area NTS 35-C
Authors: Baragar W R A
Published: November 2015

Field work for this report was done in 1985 as part of a project that was intended to clarify the relationship of the Cape Smith Belt to its encompassing tectonic setting. Accordingly, a strip of 1 degree longitude width (approximately 105 km) was to be mapped
from south of the Cape Smith Belt to the coast of Hudson Strait. Due to unfortunate circumstances only one summer's field work was completed when the project was cancelled. A preliminary map and report of the work completed that summer with few details was published earlier (Baragar et al., 1986).
The present map represents that portion of the summer's field work that lies south of the Cape Smith Belt. Work done on the north side of the Belt is represented in a separate report and map; the Kovik Bay Map Area 35F (Baragar, 2015).
A summary map of the area is shown in Fig. 1 as well as in the 1:250 000 scale geology map (accompanying pdf) where northward Archean trends can be seen to be truncated by rocks of the east-northeastward trending Paleoproterozoic Cape Smith Belt. Within this area most of the contact between the
stratified rocks of the Cape Smith Belt and underlying Archean basement is clearly unconformable (Baragar et al. 2001). In places it is obscured or replaced by south-verging thrust faults that roughly parallel the trend of the belt. In this report only the geology of the Archean rocks will be
addressed in detail. The geology of the Cape Smith Belt immediately to the north is covered in such publications as: Baragar and Scoates, 1987; Moorehead, 1988; Picard, 1989; and Baragar et al., 2001.
The Archean geology has been subdivided into four units but as shown in the legend of Fig.1 probably only two of them are to be regarded as primary lithologies; the trondhjemite-tonalite and the megacrystic granite gneisses. Gneisses of the mafic margins and of the migmatites seem to be, at least in
part, phases of the megacrystic granite gneisses. The trondhjemite-tonalite unit is interpreted as being the older but relationships between the various units are not well defined and the interpretation depends on less direct evidence and, to a degree, intuition. This will be discussed further in
the descriptions of units that follow.
Cross cutting the Archean gneissosity and widely distributed within the map area (Fig.1 and accompanying pdf) are two sets of dolerite dykes, of probable Proterozoic age, trending respectively, northward and westward. For most of the dykes, relatively short lengths were all that were observed but in
each set at least one major dyke exists that can be traced through a number of traverse intersections and on air photographs for distances of 22 km (northward set) and 9 km (westward set) respectively.
Étude géomécanique régionale de la Formation de Macasty et de sa couverture d'après les puits pétroliers et gaziers de l'Ile d'Anticosti, Province de Québec
Authors: Séjourné S
Published: November 2015

This project is part of a larger study initiated by the Geological survey of Canada, Quebec section (GSCQuebec), and which deals with the evaluation of the geomechanical parameters of the Macasty Formation and its caprock on Anticosti Island to better understand
their spatial variability and their controls.
This study enabled to document the geomechanical properties of the Macasty Formation and its caprock at a regional scale on Anticosti Island, based on the available petrophysical logs from the oil and gas wells drilled on the island and through a calibration with data from a reference well, the well
Petrolia/Corridor, Anticosti, Chaloupe No. 1 (D020). This well is the only one on the island for which an acoustic log of the S wave is available at the present time, and in the absence of laboratory data this log is required to establish the various geomechanical parameters.
A series of calibration tests was conducted in a first time so as to determine the best method to generate a synthetic acoustic log of the S wave for each of the wells considered. On the basis of the available regional data and the parameters required for the calibrations, eight oil and gas wells
were selected for the regional geomechanical study.
At the scale of the well, the results highlight the presence of clear mechanical contrasts between the Macasty Formation and the overlying and underlying formations. In a context of hydraulic fracturing these mechanical contrasts are reflected in the existence of barriers to the propagation of
hydraulic fractures outside the Macasty Formation. Furthermore, the analysis of two wells located on both sides of a regional-scale fault, the Jupiter Fault, reveals that the vicinity of the fault does not affect significantly the mechanical properties of the caprock.
At a regional scale the results demonstrate a remarkable homogeneity from a well to another, except in the South-central part of the island where a barrier to the hydraulic fractures is identified stratigraphically higher in the caprock rather than immediately above the Macasty Formation. In this
specific case the phenomenon can be real or correspond to an artifact related to methodological limitations of the study, and it is not possible to decide on the basis of currently available data.
The calibrations necessary for this study are based on the raw acoustic log of the S-wave of the sole well D020. Therefore, in the future it is recommended to confirm the robustness of the method and the results presented here by comparing them with data which may be eventually collected in new
wells.
In the scope of exploration and exploitation of unconventional reservoirs on Anticosti Island it is also particularly desirable to examine the impact that may have structural discontinuities -- faults interpreted on seismic and natural fractures networks documented at surface -- on the integrity of
the caprock of the Macasty Formation.
Document d'information sur l'interopérabilité géosémantique
Authors:   GéoConnexions,   Hickling Arthurs Low Corporation
Published: November 2015

Le présent guide fait partie d'une série de documents sur les politiques opérationnelles préparés par GéoConnexions. Il a pour but d'informer les intervenants de l'ICDG sur les principaux concepts et l'importance de
l'interopérabilité géosémantique de même que sur les technologies connexes et les exemples d'intégration de l'interopérabilité géosémantique dans les organisations.
Twenty-six archival stratigraphic sections in Paleoproterozoic to Neoproterozoic strata from the Coal Creek inlier, southern Ogilvie Mountains, Yukon
Authors: Thompson R I ,   Geological Survey of Canada, Roots C F
Published: November 2015

This Open File presents 26 stratigraphic sections measured by Bob Thompson during regional mapping of the northeast half of Dawson map area (NTS 116 B/C). The sections are previously unpublished, and figures are augmented by stratigraphic nomenclature from more
recent work. These stratigraphic sections document representative exposures of Paleoproterozoic to Neoproterozoic strata in the Coal Creek inlier, namely the Wernecke, Fifteenmile, Mount Harper, Hay Creek and 'Upper' groups.
Three dimensional groundwater flow model of the Nanoose-Deep Bay area, Nanaimo Lowland, British Columbia
Authors: Benoit N , Paradis D
Published: November 2015

The Nanaimo Lowland Groundwater Study is a collaboration between the British Columbia (BC) Ministry of Environment (MoE), Ministry of Forests, Lands, and Natural Resource Operations (MFLNRO), the Regional District of Nanaimo (RDN), and the Geological Survey of
Canada (GSC). This Open File reports on the three-dimensional (3D) groundwater flow model (3DGFM) for the Nanaimo Lowland aquifer system developed to support improved sustainable groundwater management of the Nanaimo Lowland. The study area represents a coastal strip running from Nanoose to Deep Bay
in the eastern part of Vancouver Island and covers approximately 580 km2. The groundwater flow model was based on the 3D hydrostratigraphic model (3DHSM) developed by Benoit et al. (2015). The hydrostratigraphic units were converted into a numerical grid and representative hydraulic properties were
assigned based to each unit on statistical analysis of available values. The groundwater resurgences present along the steep slopes of the main riverbanks and at the shoreline were simulated with seepage boundary conditions allowing for a vertical hydraulic link between the main Quadra Sand aquifer
and surface water bodies. Hydraulic conductivity and groundwater recharge rate were further calibrated through numerical inversion using static hydraulic heads recorded in existing wells and estimated baseflow values from streamflow records. Simulation results that two distinct groundwater flow
systems: (1) the Quadra aquifer system with groundwater divides closely matching watershed boundaries containing relatively fresh water; and (2) the extensive bedrock aquifer system with older water and a flow patterns generally directed toward the sea coast. Simulations also reveal discharge to
rivers and streams mainly from the Quadra Sand aquifer and the Capilano sediments, often locally present along the main river channels, with low contribution from the bedrock. Exception is the Englishmen River where the Quadra Sand is inexistent and the river is in direct hydraulic contact with the
bedrock aquifer. The Quadra Sand aquifer is naturally protected from sea intrusion due to the higher altitude with respect to sea level, whereas the bedrock aquifer appears vulnerable to encroachment especially under heavy pumping conditions close to the shoreline. This 3DGFM provides then a
meaningful framework for the understanding of the regional hydrogeology of Nanoose-Deep Bay aquifer system that would contributes to support sustainable management of groundwater resources.
Geotechnical data from a large landslide site at Quyon, Quebec
Authors: Wang B , Brooks G R , Hunter J A
M
Published: November 2015

A geotechnical study was initiated in 2014 to investigate the triggering mechanism of an enormous prehistorical landslide near Quyon, Quebec. The study consisted of surveys of the thickness of the glaciolacustrine deposits with a hand held seismograph, cone
penetrometer testing (CPT), seismic cone penetrometer testing (SCPT), field vane shear testing (VST), soil sampling, and laboratory testing. Preliminary results were presented in a separate paper. This Open File provides more detailed information and updated data. In summary, the measured thickness
of the Champlain Sea deposits in the region ranges from 0 m (at bedrock outcrops) to 68 m. The underlying bedrock surface forms a buried valley underlying the modern Quyon River. The glaciomarine sediments consist of clay, silty clay or clayey silt. The materials from the southern area are finer
than that of the northern area. The materials in the southern area exhibit a high to extremely high plasticity with Plasticity Index ranging from 38.6% to 68.6%. The materials from the northern area have low to high plasticity with the Plasticity Index ranging from 13.9% to 33.0%.
The clay/silt samples from 30 m depth and above have moisture content higher than the liquid limit in both the northern and southern areas. The CPT bearing factor Nkt was calibrated to be 11.5. The pore pressure bearing factor N?u varies with pore water pressure parameter Bq. The soil undrained
shear strength (Su) ranges from 22 kPa to 250 kPa. The Su profiles determined from Nkt and N?u are identical. A clay unit of continuous Su profile was identified at three CPT locations in the undisturbed areas outside the landslide scar. Absence of the low strength material and discontinuity of the
Su profiles were observed at upper elevations in the drill holes inside the landslide scar, which suggest that the upper clay unit either flowed away or was dislocated.
Improved sensitivity, safety and laboratory turnaround time in the diagnosis of pulmonary tuberculosis by use of bleach sedimentation
Authors: James Ameh , Ochei Kingsley , Emenyonu Nnamdi , Lawson Lovett
Published: November 2015

Background: Inadequate diagnostic processes and human resources in laboratories contribute to a high burden of tuberculosis (TB) in low- and middle-income countries. Direct smear microscopy is relied on for TB diagnosis; however, sensitivity rates vary. To improve sensitivity of direct microscopy, the researchers employed several approaches, including sputum digestion and concentration of acid-fast bacilli (AFB), a technique which uses commercial bleach.Objectives: This study compared methods used to diagnose active Mycobacterium tuberculosis infections.Methods: Three sputum specimens were collected from each of 340 participants in Abuja, Nigeria, over two consecutive days. Direct microscopy was performed on all specimens; following microscopy, one specimen from each patient was selected randomly for bleach sedimentation and one for Lowenstein-Jensen culture.Results: Direct microscopy produced 28.8% AFB-positive results, whilst bleach sedimentation resulted in 30.3%. When compared with the cultures, 26.5% were AFB true positive using direct microscopy and 27.1% using bleach sedimentation. Whilst the specificity rate between these two methods was not statistically significant (P = 0.548), the sensitivity rate was significant (P = 0.004).Conclusion: Based on these results, bleach increases the sensitivity of microscopy compared with direct smear and has similar specificity. When diagnosing new cases of pulmonary TB, one bleach-digested smear is as sensitive as three direct smears, reducing waiting times for patients and ensuring the safety of laboratory technicians.
Ecological considerations for intervention strategy in the development of eye health promotion policy in South Africa
Authors: Sithole Hlupheka L.
Published: November 2015

Eye health promotion is an important component of public health. To realise the essential aspects of eye health promotion, the formulation and implementation of policy as an intervention strategy is a major contributory factor and can best be described by an ecological framework. Ecological perspectives assert that people’s health affairs cannot be neatly grouped into diagnoses, symptoms and risk factors to be targeted and eliminated; this is because the core concept of an ecological model is that behaviour has many levels of influence, often including intrapersonal, interpersonal, organisational, physical environmental, and policy. Therefore, societal and personal issues can be directly linked to an ecological model that points to issues of numerous levels of influence on certain behaviours that affect the manner in which eye care services are utilised. These behaviours are therefore termed salient beliefs. Unfortunately, there is no study in South Africa that has identified the set of beliefs that are salient in any given population that might be responsible for influencing the uptake of eye care services. However, reorienting eye health care services through direct policy reforms and advocacy may change the landscape of eye health care services in South Africa.
Combinatorial topology and the global dimension of algebras arising in combinatorics
Authors: Margolis Stuart , Saliola Franco , Steinberg Benjamin
Published: November 2015

In a highly influential paper, Bidigare, Hanlon and Rockmore showed that a number of popular Markov chains are random walks on the faces of a hyperplane arrangement. Their analysis of these Markov chains took advantage of the monoid structure on the set of faces. This theory was later extended by Brown to a larger class of monoids called left regular bands. In both cases, the representation theory of these monoids played a prominent role. In particular, it was used to compute the spectrum of the transition operators of the Markov chains and to prove diagonalizability of the transition operators.

In this paper, we establish a close connection between algebraic and combinatorial invariants of a left regular band: we show that certain homological invariants of the algebra of a left regular band coincide with the cohomology of order complexes of posets naturally associated to the left regular band. For instance, we show that the global dimension of these algebras is bounded above by the Leray number of the associated order complex. Conversely, we associate to every flag complex a left regular band whose algebra has global dimension precisely the Leray number of the flag complex.
Two-dimensional curvature functionals with superquadratic growth
Authors: Kuwert Ernst , Lamm Tobias , Li Yuxiang
Published: November 2015

For two-dimensional, immersed closed surfaces

f:\Sigma \to \mathbb R^n

, we study the curvature functionals

\mathcal{E}^p(f)

and

\mathcal{W}^p(f)

with integrands

(1+|A|^2)^{p/2}

and

(1+|H|^2)^{p/2}

, respectively. Here

A

is the second fundamental form,

H

is the mean curvature and we assume

p > 2

. Our main result asserts that

W^{2,p}

critical points are smooth in both cases. We also prove a compactness theorem for

\mathcal{W}^p

-bounded sequences. In the case of

\mathcal{E}^p

this is just Langer's theorem [16], while for

\mathcal{W}^p

we have to impose a bound for the Willmore energy strictly below

8\pi

as an additional condition. Finally, we establish versions of the Palais–Smale condition for both functionals.
How to produce a Ricci flow via Cheeger–Gromoll exhaustion
Authors: Cabezas-Rivas Esther , Wilking Burkhard
Published: November 2015

We prove short time existence for the Ricci flow on open manifolds of non-negative complex sectional curvature without requiring upper curvature bounds. By considering the doubling of convex sets contained in a Cheeger–Gromoll convex exhaustion and solving the singular initial value problem for the Ricci flow on these closed manifolds, we obtain a sequence of closed solutions of the Ricci flow with non-negative complex sectional curvature which subconverge to a Ricci flow on the open manifold. Furthermore, we find an optimal volume growth condition which guarantees long time existence, and give an analysis of the long time behavior of the Ricci flow. We also construct an explicit example of an immortal non-negatively curved Ricci flow with unbounded curvature for all time.
A Mobile, Collaborative, Real Time Task List for Inpatient Environments
Authors: Ho T. , Pelletier A. , Al Ayubi S. , Bourgeois F. , Michelson K.A.
Published: November 2015

Background: Inpatient teams commonly track their tasks using paper checklists that are not shared between team members. Team members frequently communicate redundantly in order to prevent errors.

Methods: We created a mobile, collaborative, real-time task list application on the iOS platform. The application listed tasks for each patient, allowed users to check them off as completed, and transmitted that information to all other team members. In this report, we qualitatively describe our experience designing and piloting the application with an inpatient pediatric ward team at an academic pediatric hospital.

Results: We successfully created the tasklist application, however team members showed limited usage.

Conclusion: Physicians described that they preferred the immediacy and familiarity of paper, and did not experience an efficiency benefit when using the electronic tasklist.
Reconstrucción virtual del mobiliario doméstico romano a través de las fuentes antiguas
Authors: Moreno Alcaide Manuel
Published: November 2015

The aim of this paper is the recreation of the various domestic environments of the Romandomus, with particular attention to the furniture and dishes that are linked very closely with each one of the rooms within it. First, there has been a collection of ancient sources, with particular attention to the inscriptions, wall paintings and mosaics, then there has been a catalog of parts in response to various aspects such as the type of object or stay they occupied.Secondly we have proceeded to the digitization of images for late reconstruction using SketchUp8. In conclusion, we intend to virtually rebuild the Roman household furniture to make it understandable to these spaces.
La porta principalis sinistra del campamento de la Legión VII Gémina en León. De la intervención arqueológica a la restitución virtual11
Authors: Morillo Cerdán Ángel , Durán Cabello Rosalía
Published: November 2015

The archaeological interventions developed throughout 1996 deserves the discovery and conservation of the remains of the porta principalis sinistra, east gate of the Roman legionary camp of legio VII gemina, below the so-called medieval Bishop Gate (Puerta Obispo). It was built in Flavian times. At the end of the 3rd century or beginnings of the 4th A.D, the gate underwent significant changes. From 2006 we have begun the present project of virtual reconstruction based on the archaeological data of architecture, measures and constructive materials. This paper present a three-dimensional high-definition computer reconstruction of different constructive phases of the Roman gate from its origins to V century AD.
Low cost image-based modeling techniques for archaeological heritage digitalization: more than just a good tool for 3d visualization?
Authors: Galizia Mariateresa , Santagati Cettina
Published: November 2015

This study shows the first results of a research aimed at catching the potentiality of a series of low cost, free and open source tools (such as ARC3D, 123D Catch, Hypr3D). These tools are founded on the SfM (Structure from Motion) techniques and they are able to realize automatically image-based models starting from simple sequences of pictures data sets. Initially born as simple touristic 3D visualization (e.g. Photosynth) of archaeological and/or architectural sites or cultural assets (e.g. statues, fountains and so on), nowadays allow to reconstruct impressive photorealistic 3D models in short time and at very low costs. Therefore we have chosen different case studies with various levels of complexity (from the statues to the architectures) in order to start a first testing on the modeling potentiality of these tools.
Reconstrucción Infográfica de la Necrópolis Septentrional de la ciudad de Onoba12
Authors: Bermejo Meléndez Javier , Fernández Sutilo Lucía , Delgado Aguilar Salvador , Campos Carrasco Juan Manuel
Published: November 2015

The north necropolis of city was an object of an important program of building towards the change of Age destined to show before the position reached by Onoba's city in the political - economic context of the Empire. In spite of it, the knowledge of this funeral area has seen strongly determined for the system of hills and water-course in which it placed, as well as for the nonexistence of an overall view derived from the multiple research's teams that they have worked on it.
Procedural modeling historical buildings for serious games
Authors: Besuievsky Gonzalo , Patow Gustavo
Published: November 2015

In this paper we target the goal of obtaining detailed historical virtual buildings, like a castle or a city old town, through a methodology that facilitates their reconstruction. We allow having in a short time an approximation model that is flexible for being explored, analyzed and eventually modified. This is crucial for serious game development pipelines, whose objective is focused not only on accuracy and realism, but also on transmitting a sense of immersion to the player.
Rehabilitación motivacional basada en la utilización de serious games
Authors: Jaume i Capó Antoni , Varona Gómez Javier , Moyà Gabriel , Perales Francisco
Published: November 2015

Research studies show that serious games help to motivate users in rehabilitation processes, and rehabilitation results are better when users are motivated. In long term rehabilitation for maintaining capacities, the demotivation of chronic patients is common. In this work, we have implemented balance rehabilitation video game for cerebral palsy patients. The video game was developed using the prototype development paradigm and following desirable features for rehabilitation serious games presented in the literature. We have tested the video game with a set of users who abandoned therapy due to demotivation in the previous year. Results show that the set of users improved their balance and motivation.
PotuGame. Un videojuego para conocer la Universidad
Authors: Guillem Antoni , Perales Francisco José , Jaume Antoni , Buades José María
Published: November 2015

The aim of the PotuGame proposal to give a step more on strategies already developed in previous Potu Program (Programa d’Orientació i Transició a la Universitat-UIB). For that we add a new multidisciplinary component that enables high school students, teachers and researchers from UIB to share knowledge of the research conducted using a common language or a common world. Therefore it is considered very appropriate to use the technologies related to the creation of virtual worlds, especially those aimed in online video games as a means to allow vehicle for the transmission of knowledge in an interactive and fun way increasing mass participation of all components of the teaching environment at all levels. Several experiments have been developed and that have been implemented in several virtual worlds. The final tool used was the Unreal SDK.
Propuesta metodológica para la generación de recorridos virtuales interactivos
Authors: Esclapés Javier , Tejerina Daniel , Esquembre Marco Aurelio , Bolufer Joaquim
Published: November 2015

Virtual walkthroughs have become one of the most effective tools for the dissemination of archaeological heritage, particularly in those cases in which the site, by location or by their morphology, can not be visited. In this paper we describe the workflow for producing such tools, focusing on its two main phases: 3D digital documentation and the use of a game engine to create a virtual walkthrough. In this same line, as a case study, we describe the intervention in the archaeological site “Cova del Barranc del Migdia”, located on the southern face of Mount Montgó, within the Montgó Natural Park, in the town of Javea (Alicante, Spain).