bluuebunny/crossref_metadata_2025 huggingface dataset:
Cancer-secreted exosomal miR-21-5p induces angiogenesis and vascular permeability by targeting KRIT1
Authors: He Qinglian , Ye Aihua , Ye Weibiao , Liao Xiaomin , Qin Guoqiang , Xu Yongqiang , Yin Yuting , Luo Huanqian , Yi Muhua , Xian Liying , Zhang Shihao , Qin Xiyuan , Zhu Wei , Li Yuling
Published: June 2021

Cancer-secreted exosomes are critical mediators of cancer-host crosstalk. In the present study, we showed the delivery of miR-21-5p from colorectal cancer (CRC) cells to endothelial cells via exosomes increased the amount of miR-21-5p in recipient cells. MiR-21-5p suppressed Krev interaction trapped protein 1 (KRIT1) in recipient HUVECs and subsequently activated β-catenin signaling pathway and increased their downstream targets VEGFa and Ccnd1, which consequently promoted angiogenesis and vascular permeability in CRC. A strong inverse correlation between miR-21-5p and KRIT1 expression levels was observed in CRC-adjacent vessels. Furthermore, miR-21-5p expression in circulating exosomes was markedly higher in CRC patients than in healthy donors. Thus, our data suggest that exosomal miR-21-5p is involved in angiogenesis and vascular permeability in CRC and may be used as a potential new therapeutic target.
Targeting STAT3 signaling overcomes gefitinib resistance in non-small cell lung cancer
Authors: Liu Zhe , Ma Liang , Sun Yiming , Yu Wenying , Wang Xue
Published: June 2021

Lung cancer is one of the most aggressive cancers with poor prognosis and high resistance rate. The family of signal transducer and activator of transcriptions (STATs) appears to modulate resistance in non-small cell lung cancer (NSCLC). In this work, we demonstrated that STAT3/ZEB1 is a critical axis in gefitinib resistance. STAT3-targeted inhibition therefore is a new potential therapeutic strategy for gefitinib resistance in lung cancer. Our small molecule screening identified a relatively specific STAT3-targeted inhibitor, LL1. Pharmacological and biochemical studies indicated that LL1 block the activation of STAT3 via inhibiting its phosphorylation. Further in vitro and in vivo studies elucidated that LL1 sensitizes the resistance cells to gefitinib through depleting STAT3 activity and blocking STAT3/ZEB1 signaling pathways. Little toxicity of LL1 was observed in animal models. All these favorable results indicated that LL1 is a chemotherapeutic adjuvant for gefitinib resistance in NSCLC.
A universal, multifunctional, high-practicability superhydrophobic paint for waterproofing grass houses
Authors: Zhu Hai , Huang Yu , Zhang Shouwei , Jin Shiwei , Lou Xiaoding , Xia Fan
Published: June 2021

Roof leakage is a common phenomenon on rainy days and makes residents uncomfortable. Superhydrophobic materials are promising candidates to protect grass houses from rainwater. However, mechanical weakness, chemical corrosion, and UV light sensitivity are the three main challenges restricting these nonwetting materials from wider application in real life. Herein, we developed an inorganic–organic superhydrophobic paint (IOS-PA) for preparing a waterproof grass house. IOS-PA not only showed mechanical robustness and chemical anticorrosion but also displayed self-healing properties, anti-icing properties, and high and low temperature (150 °C and −196 °C) resistance. Photocatalysis was also achieved with IOS-PA, as demonstrated by organic matter (Nile red, methyl blue, and methyl orange) degradation. Moreover, extremely long-term UV resistance, i.e., resistance to UV irradiation (365 nm, 5.0 ± 0.6 mW/cm2) for 100 h and ambient sunlight for 8640 h (1 year), caused the conflicting properties of superhydrophobicity and photocatalysis to coexist in IOS-PA, further accomplishing self-cleaning for the removal of both dirt particles and organic contamination. Specifically, a grass house coated with IOS-PA exhibited favorable waterproof properties, indicating the potential to ensure comfortable living conditions for people living in undeveloped areas, even on rainy days. With a variety of excellent characteristics, IOS-PA, we believe, is advantageous for scalable production and practical application in reality.
SepF is the FtsZ anchor in archaea, with features of an ancestral cell division system
Authors: Pende Nika , Sogues Adrià , Megrian Daniela , Sartori-Rupp Anna , England Patrick , Palabikyan Hayk , Rittmann Simon K.-M. R. , Graña Martín , Wehenkel Anne Marie , Alzari Pedro M. , Gribaldo Simonetta
Published: June 2021

Most archaea divide by binary fission using an FtsZ-based system similar to that of bacteria, but they lack many of the divisome components described in model bacterial organisms. Notably, among the multiple factors that tether FtsZ to the membrane during bacterial cell constriction, archaea only possess SepF-like homologs. Here, we combine structural, cellular, and evolutionary analyses to demonstrate that SepF is the FtsZ anchor in the human-associated archaeon Methanobrevibacter smithii. 3D super-resolution microscopy and quantitative analysis of immunolabeled cells show that SepF transiently co-localizes with FtsZ at the septum and possibly primes the future division plane. M. smithii SepF binds to membranes and to FtsZ, inducing filament bundling. High-resolution crystal structures of archaeal SepF alone and in complex with the FtsZ C-terminal domain (FtsZCTD) reveal that SepF forms a dimer with a homodimerization interface driving a binding mode that is different from that previously reported in bacteria. Phylogenetic analyses of SepF and FtsZ from bacteria and archaea indicate that the two proteins may date back to the Last Universal Common Ancestor (LUCA), and we speculate that the archaeal mode of SepF/FtsZ interaction might reflect an ancestral feature. Our results provide insights into the mechanisms of archaeal cell division and pave the way for a better understanding of the processes underlying the divide between the two prokaryotic domains.
Tenth year reenrollment randomized trial investigating the effects of childhood probiotics and calcium supplementation on height and weight at adolescence
Authors: Setiawan Evania Astella , Rianda Davrina , Kadim Muzal , Meilianawati  , Susanto Fenny , Kok Frans J. , Shankar Anuraj H. , Agustina Rina
Published: June 2021

Microbiota and its modification with specific probiotics in early life could provide long term health benefits. Probiotics and calcium strengthen intestinal integrity and may support linear growth. This study investigated the long-term effects of childhood probiotics and calcium supplementation on growth in adolescence. We re-enrolled 238 adolescents aged 11–18 years from 494 children 10-years after 6-months of supplementation with either low-lactose milk fortified with low levels of calcium (LC, ∼50 mg/day, n = 53/124), with regular levels of calcium (RC, ∼440 mg/day, n = 70/126), or with regular calcium + 5 x 108 CFU/day Lactobacillus reuteri DSM 17938 (Reuteri, n = 55/124), or regular calcium + 5 x 108 CFU/day L. casei CRL 431 (Casei, n = 60/120). Changes in height-for-age z-score (HAZ) and body mass index-for-age z-score (BMIZ) were determined from the end of intervention to re-enrollment. General linear models were used to assess the effects on HAZ and BMIZ of group, gender, living area, maternal education, family income, physical activity, diet quality, nutritional status, and gut integrity as determined by urinary lactulose/mannitol ratio (L:M). Adolescent mean age was 15.3 years, mean HAZ was − 1.11, mean BMIZ was − 0.2 and median L:M (n = 155) was 0.23. Changes in HAZ and BMIZ were not significantly different between Casei, Reuteri, LC compared to RC. However, a significant decrease in BMIZ was observed among female adolescents in the Casei compared to RC group (− 0.5 SD, 95% CI − 0.8 to − 0.003, p = 0.048). Childhood probiotic and calcium supplementation may therefore selectively affect female adolescents.

Clinical trial registration: This follow-up study has been registered at www.clinicaltrials.gov, Registry name: Rina Agustina, Registration number: NCT04046289, First Registration Date 06/08/19. web link: https://www.clinicaltrials.gov/ct2/show/NCT04046289.
The proteome of the human endolymphatic sac endolymph
Authors: Ölander Christine , Edvardsson Rasmussen Jesper , Eriksson Per Olof , Laurell Göran , Rask-Andersen Helge , Bergquist Jonas
Published: June 2021

The endolymphatic sac (ES) is the third part of the inner ear, along with the cochlea and vestibular apparatus. A refined sampling technique was developed to analyse the proteomics of ES endolymph. With a tailored solid phase micro-extraction probe, five ES endolymph samples were collected, and six sac tissue biopsies were obtained in patients undergoing trans-labyrinthine surgery for sporadic vestibular schwannoma. The samples were analysed using nano-liquid chromatography-tandem mass spectrometry (nLC-MS/MS) to identify the total number of proteins. Pathway identification regarding molecular function and protein class was presented. A total of 1656 non-redundant proteins were identified, with 1211 proteins detected in the ES endolymph. A total of 110 proteins were unique to the ES endolymph. The results from the study both validate a strategy for in vivo and in situ human sampling during surgery and may also form a platform for further investigations to better understand the function of this intriguing part of the inner ear.
Molecular characterization of multidrug resistant Enterobacterales strains isolated from liver and kidney transplant recipients in Spain
Authors: Fernández-Martínez Marta , González-Rico Claudia , Gozalo-Margüello Mónica , Marco Francesc , Gracia-Ahufinger Irene , Aranzamendi Maitane , Sánchez-Díaz Ana M. , Vicente-Rangel Teresa , Chaves Fernando , Calvo Montes Jorge , Martínez-Martínez Luis , Fariñas Maria Carmen ,   ENTHERE Study Group, the Group for Study of Infection in Transplantation of the Spanish Society of Infectious Diseases and Clinical Microbiology (GESITRA-SEIMC) and the Spanish Network for Research in Infectious Diseases (REIPI), Salas Carlos , Armiñanzas Carlos , Arnaiz de las Revillas Francisco , Casafont-Morencos Fernando , Cuadrado Lavín Antonio , Fábrega Emilio , Fariñas-Álvarez Concepción , Morales Virginia Flor , Rodrigo Emilio , Ruiz San Millán Juan Carlos , Bodro Marta , Moreno Asunción , Linares Laura , Navasa Miquel , Cofan Frederic , Rodríguez Fernando , Torre-Cisneros Julián , Páez Vega Aurora , Montejo José Miguel , Blanco María José , Nieto Arana Javier , Fortún Jesús , Escudero Sánchez Rosa , Martin Dávila Pilar , Ruiz Garbajosa Patricia , Martínez Adolfo , Graus Javier , Fernández Ana , Muñoz Patricia , Valerio Maricela , Machado Marina , Olmedo María , Agnelli Bento Caroline , Rincón Sanz Cristina , Rodríguez Ferrero María Luisa , Sánchez Cámara Luis Alberto , Aguado José María , Resino Elena
Published: June 2021

The objective of this study was to analyse the mechanisms of resistance to carbapenems and other extended-spectrum-β-lactams and to determine the genetic relatedness of multidrug-resistant Enterobacterales (MDR-E) causing colonization or infection in solid-organ transplantation (SOT) recipients. Prospective cohort study in kidney (n = 142), liver (n = 98) or kidney/pancreas (n = 7) transplant recipients between 2014 and 2018 in seven Spanish hospitals. We included 531 MDR-E isolates from rectal swabs obtained before transplantation and weekly for 4–6 weeks after the procedure and 10 MDR-E from clinical samples related to an infection. Overall, 46.2% Escherichia coli, 35.3% Klebsiella pneumoniae, 6.5% Enterobacter cloacae, 6.3% Citrobacter freundii and 5.7% other species were isolated. The number of patients with MDR-E colonization post-transplantation (176; 71.3%) was 2.5-fold the number of patients colonized pre-transplantation (71; 28.7%). Extended-spectrum β-lactamases (ESBLs) and carbapenemases were detected in 78.0% and 21.1% of MDR-E isolates respectively. In nine of the 247 (3.6%) transplant patients, the microorganism causing an infection was the same strain previously cultured from surveillance rectal swabs. In our study we have observed a low rate of MDR-E infection in colonized patients 4–6 weeks post-transplantation. E. coli producing blaCTX-M-G1 and K. pneumoniae harbouring blaOXA-48 alone or with blaCTX-M-G1 were the most prevalent MDR-E colonization strains in SOT recipients.
Chamber-enriched gene expression profiles in failing human hearts with reduced ejection fraction
Authors: Luo Xin , Yin Jun , Dwyer Denise , Yamawaki Tracy , Zhou Hong , Ge Hongfei , Han Chun-Ya , Shkumatov Artem , Snyder Karen , Ason Brandon , Li Chi-Ming , Homann Oliver , Stolina Marina
Published: June 2021

Heart failure with reduced ejection fraction (HFrEF) constitutes 50% of HF hospitalizations and is characterized by high rates of mortality. To explore the underlying mechanisms of HFrEF etiology and progression, we studied the molecular and cellular differences in four chambers of non-failing (NF, n = 10) and HFrEF (n = 12) human hearts. We identified 333 genes enriched within NF heart subregions and often associated with cardiovascular disease GWAS variants. Expression analysis of HFrEF tissues revealed extensive disease-associated transcriptional and signaling alterations in left atrium (LA) and left ventricle (LV). Common left heart HFrEF pathologies included mitochondrial dysfunction, cardiac hypertrophy and fibrosis. Oxidative stress and cardiac necrosis pathways were prominent within LV, whereas TGF-beta signaling was evident within LA. Cell type composition was estimated by deconvolution and revealed that HFrEF samples had smaller percentage of cardiomyocytes within the left heart, higher representation of fibroblasts within LA and perivascular cells within the left heart relative to NF samples. We identified essential modules associated with HFrEF pathology and linked transcriptome discoveries with human genetics findings. This study contributes to a growing body of knowledge describing chamber-specific transcriptomics and revealed genes and pathways that are associated with heart failure pathophysiology, which may aid in therapeutic target discovery.
Risks and prediction of postoperative hypoparathyroidism due to thyroid surgery
Authors: Yazıcıoğlu Mustafa Ömer , Yılmaz Abdurrezzak , Kocaöz Servet , Özçağlayan Ruhşen , Parlak Ömer
Published: June 2021

We aimed to investigate the prevalence of postoperative hypoparathyroidism (PoH), the relevant factors, and predictors of transient or permanent hypoparathyroidism. The files of 352 patients who underwent bilateral total thyroidectomy alone or with central lymph node dissection and/or lateral neck dissection between June 1, 2019, and November 30, 2019, were retrospectively evaluated. Also, calcium and parathyroid hormone levels measured preoperatively and 4–6 h after surgery, follow-up examination results, and time to resolution of transient PoH were recorded. 16.48% (n = 58) of the surgical patients developed transient PoH and 3.98% (n = 14) developed permanent PoH. Length of hospital stay increased in patients who developed PoH (p < 0.001). Transient PoH developed less in patients who underwent parathyroid autotransplantation, while permanent PoH was not detected (p = 0.001). PoH development was not significantly correlated with nodule size as measured by preoperative thyroid ultrasonography (p = 0.944). Patients who had a serum PTH level ≤ 5.95 pmol/L 4–6 h after surgery had a greater risk of developing permanent PoH (OR 134.84, 95% CI 17.25–1053.82). PoH is more common in female gender and is not significantly correlated with nodule size. Parathyroid autotransplantation can prevent the development of PoH.
4-Phenylbutyrate (PBA) treatment reduces hyperglycemia and islet amyloid in a mouse model of type 2 diabetes and obesity
Authors: de Pablo Sara , Rodríguez-Comas Júlia , Díaz-Catalán Daniela , Alcarraz-Vizán Gema , Castaño Carlos , Moreno-Vedia Juan , Montane Joel , Parrizas Marcelina , Servitja Joan-Marc , Novials Anna
Published: June 2021

Amyloid deposits in pancreatic islets, mainly formed by human islet amyloid polypeptide (hIAPP) aggregation, have been associated with loss of β-cell mass and function, and are a pathological hallmark of type 2 diabetes (T2D). Treatment with chaperones has been associated with a decrease in endoplasmic reticulum stress leading to improved glucose metabolism. The aim of this work was to investigate whether the chemical chaperone 4-phenylbutyrate (PBA) prevents glucose metabolism abnormalities and amyloid deposition in obese agouti viable yellow (Avy) mice that overexpress hIAPP in β cells (Avy hIAPP mice), which exhibit overt diabetes. Oral PBA treatment started at 8 weeks of age, when Avy hIAPP mice already presented fasting hyperglycemia, glucose intolerance, and impaired insulin secretion. PBA treatment strongly reduced the severe hyperglycemia observed in obese Avy hIAPP mice in fasting and fed conditions throughout the study. This effect was paralleled by a decrease in hyperinsulinemia. Importantly, PBA treatment reduced the prevalence and the severity of islet amyloid deposition in Avy hIAPP mice. Collectively, these results show that PBA treatment elicits a marked reduction of hyperglycemia and reduces amyloid deposits in obese and diabetic mice, highlighting the potential of chaperones for T2D treatment.
A vital sign-based prediction algorithm for differentiating COVID-19 versus seasonal influenza in hospitalized patients
Authors: Yanamala Naveena , Krishna Nanda H. , Hathaway Quincy A. , Radhakrishnan Aditya , Sunkara Srinidhi , Patel Heenaben , Farjo Peter , Patel Brijesh , Sengupta Partho P.
Published: June 2021

Patients with influenza and SARS-CoV2/Coronavirus disease 2019 (COVID-19) infections have a different clinical course and outcomes. We developed and validated a supervised machine learning pipeline to distinguish the two viral infections using the available vital signs and demographic dataset from the first hospital/emergency room encounters of 3883 patients who had confirmed diagnoses of influenza A/B, COVID-19 or negative laboratory test results. The models were able to achieve an area under the receiver operating characteristic curve (ROC AUC) of at least 97% using our multiclass classifier. The predictive models were externally validated on 15,697 encounters in 3125 patients available on TrinetX database that contains patient-level data from different healthcare organizations. The influenza vs COVID-19-positive model had an AUC of 98.8%, and 92.8% on the internal and external test sets, respectively. Our study illustrates the potentials of machine-learning models for accurately distinguishing the two viral infections. The code is made available at https://github.com/ynaveena/COVID-19-vs-Influenza and may have utility as a frontline diagnostic tool to aid healthcare workers in triaging patients once the two viral infections start cocirculating in the communities.
First principles study of dense and metallic nitric sulfur hydrides
Authors: Li Xiaofeng , Lowe Angus , Conway Lewis , Miao Maosheng , Hermann Andreas
Published: June 2021

Studies of molecular mixtures containing hydrogen sulfide (H2S) could open up new routes towards hydrogen-rich high-temperature superconductors under pressure. H2S and ammonia (NH3) form hydrogen-bonded molecular mixtures at ambient conditions, but their phase behavior and propensity towards mixing under pressure is not well understood. Here, we show stable phases in the H2S–NH3system under extreme pressure conditions to 4 Mbar from first-principles crystal structure prediction methods. We identify four stable compositions, two of which, (H2S) (NH3) and (H2S) (NH3)4, are stable in a sequence of structures to the Mbar regime. A re-entrant stabilization of (H2S) (NH3)4above 300 GPa is driven by a marked reversal of sulfur-hydrogen chemistry. Several stable phases exhibit metallic character. Electron–phonon coupling calculations predict superconducting temperatures up to 50 K, in theCmmaphase of (H2S) (NH3) at 150 GPa. The present findings shed light on how sulfur hydride bonding and superconductivity are affected in molecular mixtures. They also suggest a reservoir for hydrogen sulfide in the upper mantle regions of icy planets in a potentially metallic mixture, which could have implications for their magnetic field formation.
N-Glycosylation in isolated rat nerve terminals
Authors: Matthies Inga , Abrahams Jodie L. , Jensen Pia , Oliveira Tiago , Kolarich Daniel , Larsen Martin R.
Published: June 2021

Glycomics and sialiomics of isolated synaptosomes reveal distinct glycosylation of surface proteins localized in the active zone of synapses.
Bi2O3 nano-flakes as a cost-effective antibacterial agent
Authors: Geoffrion Luke D. , Medina-Cruz David , Kusper Matthew , Elsaidi Sakr , Watanabe Fumiya , Parajuli Prakash , Ponce Arturo , Hoang Thang Ba , Brintlinger Todd , Webster Thomas J. , Guisbiers Grégory
Published: June 2021

Bismuth oxide nano-flakes attacking Gram positive and Gram negative bacteria.
A photoelectrochemical sensor based on an acetylcholinesterase-CdS/ZnO-modified extended-gate field-effect transistor for glyphosate detection
Authors: Yu Jiarui , Lin Jingyu , Li Jianping
Published: June 2021

A photoelectrochemical enzyme biosensor based on extended-gate field-effect transistor was constructed. Glyphosate was determined sensitively based on acetylcholinesterase inhibition with a detect limit of 3.8 × 10−16 mol L−1.
Revealing the signaling regulation of hydrogen peroxide to cell pyroptosis using a ratiometric fluorescent probe in living cells
Authors: Yang Guanqing , Zhu Tong , Wang Dong , Liu Zhengjie , Zhang Ruilong , Han Guangmei , Tian Xiaohe , Liu Bianhua , Han Ming-yong , Zhang Zhongping
Published: June 2021

A ratiometric fluorescent probe with a large emission shift is capable of accurately tracking H2O2 in sophisticated pyroptosis events.
Molecular adduct of amantadine ferulate presents a pathway for slowingin vitro/vivoreleases and raising synergistic antiviral effectsviadual optimization salification strategy
Authors: Niu Yuan-Yuan , Wang Ling-Yang , Yu Yue-Ming , Li Yan-Tuan , Wu Zhi-Yong , Yan Cui-Wei
Published: June 2021

The first synthesized antiviral drug-nutriment molecular salt demonstrating simultaneous slowed-release and synergistically enhanced antiviral effects is studied theoretically and experimentally.
Polymers under nanoconfinement: where are we now in understanding local property changes?
Authors: Roth Connie B.
Published: June 2021

Polymers in nanoconfined geometries have their properties altered by the presence of interfaces. Gradients in local glass transition and related properties near different types of interfaces are compared and contrasted.
Coagulation of organic pollutants by Moringa oleifera protein molecules: in silico approach
Authors: Adeleke Victoria T. , Adeniyi Adebayo A. , Lokhat David
Published: June 2021

This study used a molecular dynamics simulation approach to predict and evaluate the coagulation of organic pollutants around the Moringa oleifera 2S albumin protein extracted from the seed.
Fabrication of a nanoscale homogeneous lead azide@carbon fiber film with low electrostatic sensitivity by in situ synthesis
Authors: Yan Zhenzhan , Yang Li , Han Ji-Min , Li Haojie , Huo Junda
Published: June 2021

In this work, a nanoscale carbon-based lead azide explosive film was prepared by electrospinning, carbonization, in situ azidation reactions, and other steps using cheap and easily available lead acetate as the raw material.
Hybrid phosphorus–viologen dendrimers as new soft nanoparticles: design and properties
Authors: Majoral Jean-Pierre , Zablocka Maria , Ciepluch Karol , Milowska Katarzyna , Bryszewska Maria , Shcharbin Dzmitry , Katir Nadia , El Kadib Abdelkrim , Caminade Anne-Marie , Mignani Serge
Published: June 2021

Design of new families of dendritic soft nanoparticles constituted of phosphorus, viologen and carbosilane fragments and their properties as nanomaterials and applications in biology.
Molecular design of anticancer drugs from marine fungi derivatives
Authors: Cao Duc Tuan , Huong Doan Thi Mai , Pham Van Cuong , Minh Le Thi Hong , Chae Jung-Woo , Yun Hwi-yeol , Na Min-Kyun , Kim Young-Ho , Pham Minh Quan , Nguyen Van Hung
Published: June 2021

Five compounds originating from marine fungi speciesAspergillussp. andPenicilliumsp. were found to be highly potent inhibitors of cancer therapy target, Hsp90, using molecular docking and FPL calculations.
Determination of folic acid by capillary zone electrophoresis with indirect chemiluminescence detection
Authors: Zhao Tangjuan , Lin Huaping , Li Nan , Shi Hongmei , Kang Weijun , Xu Xiangdong
Published: June 2021

A capillary electrophoresis method with on-line inhibited chemiluminescence detection was first used to determine folic acid.
Novel oxygen-generation from electrospun nanofibrous scaffolds with anticancer properties: synthesis of PMMA-conjugate PVP–H2O2 nanofibers, characterization, and in vitro bio-evaluation tests
Authors: Salim Samar A. , Kamoun Elbadawy A. , Evans Stephen , Taha Tarek H. , El-Fakharany Esmail M. , Elmazar Mohamed M. , Abdel-Aziz A. F. , Abou-Saleh R. H. , Salaheldin Taher A.
Published: June 2021

Released oxygen plays a critical role in reducing destructive tumor behavior.
Time dependence of domain structures in potassium sodium niobate-based piezoelectric ceramics
Authors: Yang Jia , Gao Zhipeng , Liu Yi , Xiong Zhengwei , Zhang Faqiang , Fu Zhengqian , Xu Fangfang , Chen Xuefeng , Yang Qiang , Fang Leiming
Published: June 2021

The ferroelectric domain structure of Li-doped (K,Na)NbO3 changed naturally as time passed, and most of the change occurred in the 180° domain wall, while the 60°/120° domains remained nearly unchanged.
Construction of cyclopentane-fused coumarins via DBU-catalyzed [3+2] cycloaddition of 3-homoacyl coumarins with cyclic 1-azadienes
Authors: Lin Huawei , Yang Huimin , Gong Qi , Luo Shan , Gu Jing , Cao Xiaoqun , Mao Biming , Ge Yanqing , Yuan Chunhao
Published: June 2021

A metal-free DBU catalyzed [3+2] cycloaddition of 3-homoacyl coumarins with cyclic 1-azadienes has been developed for the synthesis of cyclopentane-fused coumarins with excellent diastereoselectivity and complete chemoselectivity.
Correction: Characterization of an exopolysaccharide from probiont Enterobacter faecalis MSI12 and its effect on the disruption of Candida albicans biofilm
Authors: Kiran G. Seghal , Priyadharshini S. , Anitha K. , Gnanamani Elumalai , Selvin Joseph
Published: June 2021

Correction for ‘Characterization of an exopolysaccharide from probiont Enterobacter faecalis MSI12 and its effect on the disruption of Candida albicans biofilm’ by G. Seghal Kiran et al., RSC Adv., 2015, 5, 71573–71585, DOI: 10.1039/C5RA10302A.
Alkynyl triazenes enable divergent syntheses of 2-pyrones
Authors: Tan Jin-Fay , Bormann Carl Thomas , Severin Kay , Cramer Nicolai
Published: June 2021

Substituted 2-pyrones are accessed in a silver-catalyzed one-pot process between propiolic acids and 1-alkynyl triazenes. Subsequent diversifying replacement of the triazenyl unit under 1,5-carbonyl transposition yields rare 2-fluoro pyrones.
First-principles formulation of spinel-like structured Li(4−3x)YxCl4 as promising solid-state electrolytes to enable superb lithium ion conductivity and matching oxidation potentials to high-voltage cathodes
Authors: Huang Yuanyuan , Yu Yuran , Xu Hongjie , Zhang Xiangdan , Wang Zhuo , Shao Guosheng
Published: June 2021

Halide solid-state electrolytes (SSEs) have attracted great attention as potential electrolytes for all solid-state batteries (ASSBs) owing to their high oxidation potentials, excellent ductility, and good resilience to humidity.
Oriented growth of semiconducting TCNQ@Cu3(BTC)2 MOF on Cu(OH)2: crystallographic orientation and pattern formation toward semiconducting thin-film devices
Authors: Okada Kenji , Mori Keyaki , Fukatsu Arisa , Takahashi Masahide
Published: June 2021

Oriented film and pattern of TCNQ@Cu3(BTC)2(HKUST-1) fabricated via epitaxial growth exhibit anisotropic electrical properties toward MOF-based (flexible) thin-film smart device applications, such as transistors and thermoelectric thin films.
Imidazole-functionalized polyketone-based polyelectrolytes with efficient ionic channels and superwettability for alkaline polyelectrolyte fuel cells and multiple liquid purification
Authors: Zhou Yi-Cun , Zhang Zheng-Min , Zhou Ling , Bao Rui-Ying , Liu Zheng-Ying , Yang Ming-Bo , Yang Wei
Published: June 2021

Imidazole-functionalized polyketone-based polyelectrolytes with efficient ionic channels and superwettability for alkaline polyelectrolyte fuel cells and multiple liquid purification.
Selenium atom on phosphate enhances specificity and sensitivity of DNA polymerization and detection
Authors: Luo Guangcheng , Zhang Jun , Yang Mei , He Hongfei , Huang Zhen
Published: June 2021

This study reported a unique mechanism of a single selenium-atom modified dNTP to enhance polymerization specificity, enabling us to develop selenium enhanced specific isothermal amplification (SEA) with high specificity and sensitivity.
Cancer cell membrane-coated nanogels as a redox/pH dual-responsive drug carrier for tumor-targeted therapy
Authors: Xu Weide , Wang Jilong , Li Qinghua , Wu Chenghu , Wu Lingling , Li Kaiqiang , Li Qin , Han Qing , Zhu Jingjing , Bai Yongheng , Deng Junjie , Lyu Jianxin , Wang Zhen
Published: June 2021

Redox/pH dual-responsive nanogels have shown great advantages in enhancing tumor chemotherapy.
Hydrophilic and anti-adhesive modification of porous polymer microneedles for rapid dermal interstitial fluid extraction
Authors: Liu Pei , Du Hongyao , Wu Zhuoli , Wang Hua , Tao Juan , Zhang Lianbin , Zhu Jintao
Published: June 2021

A facile and mild polydopamine (PDA) and poly(ethylene glycol) (PEG) coating strategy is reported for hydrophilic and anti-adhesive modification of porous polymer MNs from a phase inversion method.
Dual-emission Eu-doped Ca2−xSrxPN3nitridophosphate phosphors prepared by hot isostatic press
Authors: Fang Mu-Huai , Hsueh Hsi-Ping , Vasudevan Thangaraji , Huang Wen-Tse , Bao Zhen , Majewska Natalia , Mahlik Sebastian , Sheu Hwo-Shuenn , Liu Ru-Shi
Published: June 2021

Here, we demonstrate a series of Ca2−xSrxPN3:Eu2+nitridophosphate phosphors synthesized through a hot isostatic press with unexpected dual-emission in the red and infrared regions.
Mechanically enhanced healable and recyclable silicone with dynamic hindered urea bond for flexible electronics
Authors: Sun Wenjie , Zhang Lei , Wang Shuang , Mao Jiale , Luo Jiaming , Chen Yu , Cheng Yonghong
Published: June 2021

A silicone-containing dynamic hindered urea bond for flexible electronic substrates is developed with enhanced mechanical strength and healing ability simultaneously.
Twisted small organic molecules for high thermoelectric performance of single-walled carbon nanotubes/small organic molecule hybrids through mild charge transfer interactions
Authors: Jeon Yongjun , Jang Jae Gyu , Kim Sung Hyun , Hong Jong-In
Published: June 2021

Twisted small organic molecules (SOMs) enhance the thermoelectric performance of single-walled carbon nanotubes/SOM hybrid films by dramatically increasing the Seebeck coefficient and minimising the inevitable reduction in electrical conductivity.
Solution-processed high-performance p-channel copper tin sulfide thin-film transistors
Authors: Mude Narendra Naik , Bukke Ravindra Naik , Jang Jin
Published: June 2021

We introduce a solution-processed copper tin sulfide (CTS) thin film to realize high-performance of thin-film transistors (TFT) by optimizing the CTS precursor solution concentration.
Nucleation management for the ambient fabrication of high-performance perovskite photodetectors with the eco-friendly tert-butanol anti-solvent
Authors: Tang Xin , Li Tengteng , Li Qingyan , Zhao Hongliang , Wang Silei , Li Mengyao , Hao Xuanruo , Zhang Yating , Yao Jianquan
Published: June 2021

We investigated the influence of tert-butanol (TBA) on the perovskite nucleation mechanism in ambient atmosphere, and found that TBA could form high-quality perovskite films with enhanced optoelectronic properties.
Optimal time allocation for throughput maximization in backscatter assisted wireless powered communication networks
Authors: Sun Juan , Zhang Shubin , Chi Kaikai
Published: June 2021

Integrating backscatter communication (BackCom) into wireless powered communication networks (WPCNs) makes it possible to transmit information and harvest energy simultaneously, which is regarded as a promising method to enhance the throughput. A very important issue is how to allocate the charging time and transmitting time to efficiently utilize the energy in hybrid access point (HAP) so as to improve the network performance. This paper adopts convex optimization to handle the time allocation for both WPCNs and BackCom users. A two‐stage efficient algorithm is proposed to solve the problem of sum‐throughput maximization (STM) subject to the basic throughput requirements of BackCom users, where the Lagrange duality method is applied at the first‐stage, while golden section and bisection method are jointly used at the second‐stage. In order to solve the throughput unfairness among nodes in the STM problem, the common‐throughput maximization (CTM; i.e. the worst node's throughput) problem is further considered. This problem is decomposed into a master problem and a sub‐problem, which are solved in a progressive manner. Simulation results show that the proposed methods obtain substantial improvement compared to the benchmark scheme.
Array antenna equipped UAV‐BS for efficient low power WSN and its theoretical analysis
Authors: Lumbantoruan Hendrik , Adachi Koichi
Published: June 2021

In a wireless sensor network consisting of a large number of sensor nodes (SNs), an efficient communication scheme is crucial to boost data collection efficiency. Furthermore, SN is required to communicate by the low transmission power to prolong its battery life. However, SNs located at the edge of the communication area may fall into the outage as the signal‐to‐noise power ratio fails to surpass a certain threshold. Moreover, signal collision due to the interferers may deteriorate the packet delivery rate. An unmanned aerial vehicle‐base station (UAV‐BS) is an attractive solution to lower outage probability and enhance communication efficiency. Here, outage probability and capturing failure probability performance of a rotational angle division multiple access (RADMA), which is realized by UAV‐BS with an array antenna, are analytically evaluated. The numerical performance evaluation is conducted to elucidate the performance improvement of RADMA under low power wide‐area network setup. Numerical simulation results show that RADMA can suppress the packet loss ratio 77%, shorten the transmission time 25%, and reduce the required transmission energy 20%.
Total transfer capability assessment of HVDC tie‐lines in asynchronous grids
Authors: Deng Buqing , Wen Yunfeng , Jiang Xiaoliang
Published: June 2021

This paper discusses how frequency‐stable operational decision‐making of asynchronous grids with intensive high‐capacity HVDC tie‐lines, can be achieved leveraging a novel total transfer capability (TTC) evaluation approach. This problem is formulated as a hierarchical optimization model with multiple decision‐makers, in which the master problem is solved by the coordinator to determine the base case maximum acceptable transmission power of each HVDC tie‐line, while the sending‐ and receiving‐end grid's local TSO each autonomously solves a frequency constrained optimal power flow sub‐problem. Coordinated fast and slow frequency arrest strategies are fully integrated into the TTC assessment framework, which not only ensure that last‐resort protections are not triggered following the HVDC bi‐pole block contingency, but also take advantage of the potential control capability of the sending‐ and receiving‐end grids and would therefore increase the TTC of HVDC tie‐lines. A decentralized algorithm based on accelerated analytical target cascading is developed to solve the formulated model. Case studies on a modified two‐area RTS‐96 system and a practical large‐scale system demonstrate the effectiveness of the proposed approach.
Implementation of uniaxial perfectly matched layer based on hexahedron element in discontinuous Galerkin time domain
Authors: Xiao Zhennan , Wei Bing , Ge Debiao
Published: June 2021

The uniaxial perfectly matched layer (UPML), an important link in the numerical calculation of the discontinuous Galerkin time domain (DGTD), truncates the size of the computational domain and absorbs the outward‐travelling waves. In traditional DGTD, tetrahedral meshes are used to divide the computational domain. These meshes are also used in UPML. As the scope of the computational domain is wide, many meshes will be generated after the UPML division wraps the external part of the domain, thereby resulting in inefficient computation. The use of a UPML in DGTD form based on hexahedral meshes is proposed. The internal propagation and UPML regions are divided by a tetrahedral element and a hexahedral element, respectively. Among the relevant numerical examples given, a few cases are analysed to demonstrate the feasibility of the proposed method: the high efficiency of the UPML with hexahedral mesh, attenuation of electromagnetic waves inside the UPML, and relative error of the electric field values at the observation points.
Co(II) coordination polymer: Treatment activity on vulvovaginal candidiasis by inhibiting the growth of the Candida albicans
Authors: Sun Huaqin , Li Yanxia , Ding Zhaoxia , Xu Shucui , Cui Qiulian
Published: June 2021

By the reaction between Co(NO3)2·6H2O and 4‐(bis(4‐(pyridin‐4‐yl)phenyl)amino)benzoic acid (Hbpba), a triphenylamine‐functionalized ligand in CH3CN and N,N‐dimethylformamide (DMF) mixed solvent under the solvothermal conditions, a new coordination polymer (CP) containing Co(II) has been successfully prepared, and its chemical formula is [Co(bpba)(NO3)] (1). The colony‐forming unit (CFU) numbers of the Candida albicans after the compound treatment was measured with diluted micro‐plates assay. In addition to this, the inflammatory cytokines released into the vaginal discharge was determined with enzyme linked immunosorbent assay (ELISA) detection kit. Both pyridine and carboxyl groups have the capabilities to provide polar atoms for interacting with the active sites on target protein, however, results from molecular docking showed that only carboxyl group exhibited activity.
Research on the application of nanometre fiso interferometer for phase and phase element detection signal processing
Authors: Feng Fei , Qin Li , Li Xiuyuan , Li Yingxue
Published: June 2021

The use of nanometre fiso interferometer to measure heterodyne interference signals at the same time for phase and phase element detection and phase‐locked frequency multiplication counting is employed here. After a certain logic mixing, a set of measurement results with a certain degree of redundancy can be obtained; the test results can be measured and resolved. The rate is better than 0.1 nm, and the measurement range is not limited by the λ/2 period, thus overcoming the previous problems that is the measurement range of the phase measurement method is limited to one period and the resolution of the phase‐locked frequency multiplication counting method is not easy to improve.
Application of an adaptive Bayesian‐based model for probabilistic and deterministic PV forecasting
Authors: Abedinia Oveis , Bagheri Mehdi , Agelidis Vassilios G.
Published: June 2021

Accurate prediction of solar photovoltaic plant energy generation is essential for optimal planning and operation of modern power systems, and incorporating such plants into the energy sector. In this study, an adaptive Gaussian mixture method (AGM) and a developed variational Bayesian model (VBM) inference through multikernel regression (MkR) are utilized to assist desirable precise prediction. In this model, the MkR processes the multiresolution solar energy signal, and then the AGM models the complex signals forecasting error. Finally, the proposed model can be optimized, and the concurrent output of the solar energy signal in both probabilistic and deterministic status can be attained through the introduction of the VBM. The solar energy output of an actual plant, including four measurement sites provided the data for the study. The results confirmed that the proposed model delivers higher prediction accuracy for both probabilistic and deterministic forecasts when compared with other well‐known models.
Perspectives of the oil potential of the Bazhenov formation within the Kogalym top of the Surgut arch
Authors: Spiridonov D.A.
Published: June 2021

Based on the analysis of the geological structure of the territory, mineral composition of rocks and bedding conditions, the most promising areas for the development of the Bazhenov formation were localized.
Development of technology for destroying stable water-in-oil emulsions by ultrasonic method at the mobile well production preparing unit
Authors: Lekomtsev A.V. , Stepanenko I.B.
Published: June 2021

Treatment of production fluids to meet the requirements of the first quality group for commercial purposes is becoming more relevant every year in the Perm Region. Most operational facilities are in the final stages of development and characterized by the high water content of production fluids, which later leads to the formation of water-in-oil emulsions (WOEs) during transportation and field preparation. When treated by traditional methods, such as thermal and thermo chemical gravity sedimentation, stable WOEs are not amenable to destruction. These preparation methods are easy to use but do not always provide the expected result. In this regard, an urgent task is to develop and implement new technologies for the preparation of hydrocarbons, which can be used separately from traditional methods, or in combination with them. This method is called ultrasound impact (USI). This article describes regularities in the influence of various parameters on the efficiency of stable water-in-oil emulsion destruction during field-based treatment with the use of USI. The paper describes the experience of using USI, as well as the high destruction efficiency of stable water-in-oil emulsions in comparison with traditional methods. The authors of the article conducted pilot tests using a mobile unit for treating production fluids with stable WOEs pre-treated by ultrasound. Following test results, the technological effect has been evaluated and recommendations for the practical application of the proposed method have been made.
Analysis the influence of natural non-toxic components on physicochemical parameters of drilling fluids
Authors: Belukhin A.I. , Veliev R.Ya. , Vasyokha M.V. , Belozerov A.A.
Published: June 2021

Objective: to analyze the effect of non-toxic components on physical andchemical characteristics of drilling fluids. Methodology: determination of physical characteristics (density, plastic viscosity, yield point, effective viscosity, gel strength, water cut, mud cake thickness), determination of chemical characteristics (ph). results: threeиdifferent drilling fluids were prepared, their physical and chemical characteristics were studied, a Comparative analysis was carried out, the impact on the marine ecosystem was assessed. Conclusions: the considered drilling fluids are competitive with others fluids used in well construction in terms of their physical and chemical properties, also the less damage to the environment is expected.
Optimal method of Arctic hydrocarbons production-and-supply system implementation
Authors: Bratskikh D.S. , Schipachev A.M. , Bukov V.A.
Published: June 2021

One of the most important issues in the development of the Arctic shelf is the rationality of transportation. Selection of the optimal method is an integral part of the project, in the framework of which this article is written. Earlier all possible methods and their advantages and disadvantages were evaluated. Within the framework of this article, t optimal method for the development of reserves on the Arctic shelf will be proposed, taking into account the possibilities of development and the effectiveness of subsequent transportation to the importing countries. The risks of gas hydrates were considered. The prospects of development of the Northern Sea Route between Russia and Asian countries are assessed; the cost of transportation of liquefied natural gas and compressed natural gas from the Barents Sea to Central Europe is compared. The hydraulic calculation of the selected section of the gas pipeline network is conducted. The economic calculation of the project as a whole is accomplished. The optimal location of the route in relation to the reserves in the Barents Sea has been chosen. Pressure losses in the selected zone were no more than 12.24 MPa with pipeline pressure from 8 to 16 MPa. In this case, condensation and subsequent formation of gas hydrates are not possible. Using only three sections of the network, the profit of the project will be 223 billion rubles per year. In accordance with this the best way of hydrocarbons realization in the Arctic is a combined method of transportation with modern methods of extraction and pipelaying laying.
Substantiation of methods of improving safety of pipeline gas transportation
Authors: Kurasov O.A. , Burkov P.V.
Published: June 2021

Ensuring the operational efficiency of hazardous production facilities throughout their entire service life becomes a formidable challenge associated with coordinating thorough monitoring of such facilities, assessing their exposure, mitigation and sustainability, and taking measures to minimize and prevent negative outcomes that can lead to negative consequences, including human fatalities, injuries and economic losses. At the same time, the optimal choice of the ratio between levels of risk and costs of identification, regulation and increase in the resource will ensure both a reduction to a minimum of the risk of failures in gas pipeline systems and increase the efficiency of resource use to maximize technogenic safety. The paper proposes a methodology for the calculation of risk indicators and the probability of emergencies on gas networks and gas distribution facilities during their operation in normal and emergency situations.
Log-based prediction of pore pressure and its relationship to compressional velocity, shear velocity and Poisson’s ratio in gas reservoirs; Case study from selected gas wells in Iran
Authors: Nikou E. R. , Aghaei H. , Ghaedi M. , Jafarpour H.
Published: June 2021

A precise identification of pore fluid pressure (PP) is of great significance, specifically, in terms of drilling safety and reservoir management. Despite numerous work have been carried out for prediction of PP in oil reservoirs, but there still exists a tangible lack of such work in gas hosting rocks. The present study aims to discuss and evaluate the application of a number of existing methods for prediction of PP in two selected giant carbonate gas reservoirs in south Iran. For this purpose, PP was first estimated based on the available conventional log data and later compared with the PP suggested by Reservoir Formation Test (RFT) and other bore data. At the end, it has been revealed that while PP prediction is highly dependent on the type of litho logy in carbonates, the effect of fluid type is negligible. Moreover, the velocity correlations work more efficiently for the pure limestone/dolomite reservoirs compared with the mixed ones.