bluuebunny/crossref_metadata_2025 huggingface dataset:
The C-terminal tail guides assembly and degradation of membrane proteins
Authors: Sun Sha , Mariappan Malaiyalam
Published: November 2019

A large number of newly synthesized membrane proteins in the endoplasmic reticulum (ER) are assembled into multi-protein complexes, but little is known about the mechanisms required for either assembly or degradation of unassembled membrane proteins. We find that C-terminal transmembrane domains (C-TMDs) with shorter tails are inefficiently inserted into the ER membrane since the translation is terminated before they emerge from ribosomes. These TMDs of insufficient hydrophobicity are post-translationally retained by the Sec61 translocon, thus providing a time window for efficient assembly with TMDs from partner membrane proteins. The unassembled C-TMDs are slowly flipped into the ER lumen. While the luminal chaperone BiP captures flipped C-TMDs with long tails and routes them to the ER-associated quality control, C-TMDs with shorter tails are diffused into the nuclear membrane. Thus, our studies suggest that C-terminal tails harbor important biochemical features for both biosynthesis and quality control of membrane protein complexes.
Inspiratory muscle training in young, race-fit Thoroughbred racehorses during a period of detraining
Authors: Katz Lisa M. , Stallard Jessica , Holtby Amy , Hill Emmeline W. , Allen Kate , Sweeney James
Published: November 2019

Although inspiratory muscle training (IMT) is reported to improve inspiratory muscle strength in humans little has been reported for horses. We tested the hypothesis that IMT would maintain and/or improve inspiratory muscle strength variables measured in Thoroughbreds during detraining. Thoroughbreds from one training yard were placed into a control (Con,n=3 malesn=7 females; median age 2.2±0.4 years) or treatment group (Tr,n=5 males,n=5 females; median age 2.1±0.3 years) as they entered a detraining period at the end of the racing/training season. The Tr group underwent eight weeks of IMT twice a day, five days per week using custom-made training masks with resistance valves and an incremental threshold of breath-loading protocol. An inspiratory muscle strength test to fatigue using an incremental threshold of breath-loading was performed in duplicate before (T0) and after four (T1) and eight weeks (T2) of IMT/no IMT using a custom-made testing mask and a commercial testing device. Inspiratory measurements included the total number of breaths achieved during the test, average load, peak power, peak volume, peak flow, energy and the mean peak inspiratory muscle strength index (IMSi). Data was analysed using a linear mixed effects model,P≤0.05 significant. There were no differences for inspiratory measurements between groups at T0. Compared to T0, the total number of breaths achieved (P=0.02), load (P=0.003) and IMSi (P=0.01) at T2had decreased for the Con group while the total number of breaths achieved (P<0.001), load (P=0.03), volume (P=0.004), flow (P=0.006), energy (P=0.01) and IMSi (P=0.002) had increased for the Tr group. At T2the total number of breaths achieved (P<0.0001), load (P<0.0001), volume (P=0.02), energy (P=0.03) and IMSi (P<0.0001) were greater for the Tr than Con group. In conclusion, our results support that IMT can maintain and/or increase aspects of inspiratory muscle strength for horses in a detraining programme.
A deep learning framework for improving protein interaction prediction using sequence properties
Authors: Guo Yi , Chen Xiang
Published: November 2019

Motivation

Almost all critical functions and processes in cells are sustained by the cellular networks of protein-protein interactions (PPIs), understanding these is therefore crucial in the investigation of biological systems. Despite all past efforts, we still lack high-quality PPI data for constructing the networks, which makes it challenging to study the functions of association of proteins. High-throughput experimental techniques have produced abundant data for systematically studying the cellular networks of a biological system and the development of computational method for PPI identification.

Results

We have developed a deep learning-based framework, named iPPI, for accurately predicting PPI on a proteome-wide scale depended only on sequence information. iPPI integrates the amino acid properties and compositions of protein sequence into a unified prediction framework using a hybrid deep neural network. Extensive tests demonstrated that iPPI can greatly outperform the state-of-the-art prediction methods in identifying PPIs. In addition, the iPPI prediction score can be related to the strength of protein-protein binding affinity and further showed the biological relevance of our deep learning framework to identify PPIs.

Availability and Implementation

iPPI is available as an open-source software and can be downloaded from https://github.com/model-lab/deeplearning.ppi

Contact

xiang-chen@zju.edu.cn
Persuasive language of responsible organisation? A critical discourse analysis of corporate social responsibility (CSR) reports of Nigerian oil companies
Authors: Nwagbara Uzoechi , Belal Ataur
Published: November 2019

Purpose

The purpose of this paper is to investigate how language (choice) in CSR reports of leading oil companies in Nigeria is used to portray an image of “responsible organisation”.

Design/methodology/approach

This paper draws insights from communication studies (persuasion theory) and critical discourse analysis (CDA) studies to discursively unpack all those subtle and visible, yet equally invisible, linguistic strategies (micro-level elements): wording (single words), phrases and chains of words (clauses/sentences). These linguistic strategies (micro-level elements) proxy organisational discourses (meso-level elements), which are reflective of wider social practices (macro-level elements). The authors base the investigation on CSR reports of six leading oil companies in Nigeria from 2009 to 2012.

Findings

The findings of this study reveal that (leading) Nigerian oil companies linguistically use CSR reports to persuasively construct and portray the image of “responsible organisation” in the eyes of wider stakeholders (the communities) despite serious criticism of their corporate (ir) responsibility.

Originality/value

As opposed to the previous content analysis based studies, this paper contributes to the emerging stream of CDA studies on CSR reporting by providing a finer-grained linguistic analytical schema couched in Fairclough’s (2003) approach to CDA (and persuasion theory). This helps to unravel how persuasive language/discourse of responsible organisation is enacted and reproduced. The authors thus respond to the calls for theoretical plurality in CSR reporting research by introducing persuasion theory from communication studies literature which has hitherto been rarely applied.
Causes and consequences of voluntary assurance of CSR reports
Authors: Clarkson Peter , Li Yue , Richardson Gordon , Tsang Albert
Published: November 2019

Purpose

The purpose of this paper is twofold. First, the authors investigate a firm’s decision to provide a CSR report, and if so, whether to have the report assured and to seek higher quality assurance as reflected through the choices of the scope of the assurance and type of assurer, Big 4 accounting firm vs specialist consultant. Second, the authors investigate the impact of voluntary assurance of CSR reports, assurance scope and type of assurer on the likelihood of inclusion in the DJSI and on market valuation.

Design/methodology/approach

The study’s sample consists of 17,050 firm-year observations from 40 countries with CSR reports available from Corporate Register and ESG metrics available from ASSET4 over the period 2009–2015. The study first empirically examines the associations between CSR commitment and each of CSR report provision, CSR report assurance, assurance scope and type of assurer. It then examines that association between both inclusion in the DJSI and market valuation with each of CSR report assurance, assurance scope and type of assurer, using inclusion in the DJSI as an objective measure of a firm’s reputation for sustainability given its recognition as a leading indicator for corporate sustainability and market valuation as a reflection of the broader set of capital market participants.

Findings

The authors establish two key findings consistent with the predictions of signaling theory. First, we show that high CSR commitment firms are more likely to: provide standalone CSR reports; obtain assurance; obtain assurance from a Big 4 accounting firm; and, adopt higher assurance scope. Second, the authors find that both CSR report assurance and assurance scope increase the likelihood of inclusion in the DJSI, but that the type of assurance provider does not. Alternatively, the authors find that capital market participants appear to value the provision of a CSR report only when it is assured by a Big 4 accounting firm.

Originality/value

The results in the existing literature exploring the capital market benefits to CSR Assurance have been mixed. Firms that voluntarily obtain CSR Assurance incur a cost in doing so and must perceive a net benefit from obtaining such assurance. Despite the limited guidance currently provided by existing CSR standards, we establish the existence of benefits to obtaining CSR Assurance in terms of enhanced likelihood of DJSI inclusion and, more generally, enhanced market valuation. The discussions with DJSI analysts indicate that CSR assurance does enhance the perceived reliability of CSR data, thus improving user confidence.
Managerial overconfidence, firm transparency, and stock price crash risk
Authors: Liang Quanxi , Ling Leng , Tang Jingjing , Zeng Haijian , Zhuang Mingming
Published: November 2019

Purpose

The purpose of this paper is to empirically analyze whether and how managerial overconfidence affects stock price crash risk.

Design/methodology/approach

Based on a large sample of Chinese non-state-owned firms from 2000 to 2012, this study employs methods including multiple linear regression model, Heckman two-stage treatment effect procedure, firm fixed effects model and event study to clarify the causality relationship between managerial overconfidence and crash risk.

Findings

The authors find that firms with overconfident managers (chief executive officer or board chairs) are more likely to experience future stock price crashes than firms with non-overconfident managers. The effect of overconfidence on crash risk is more pronounced for firms with low transparency, suggesting that firm opacity facilitates overconfident managers’ bad news hoarding activities, which, in turn, increases stock price crash risk. The authors also show evidence that overconfident managers tend to disclose good news in a timely manner.

Originality/value

The authors add to the growing literature on stock price crash risk. Specifically, the authors find that the cognitive bias of board chair plays an important role in the bad news hoarding activities, thereby increasing the likelihood of stock price crash. This study also contributes to the literature that addresses the effects of managerial overconfidence on corporate finance issues.
Site selection criteria for temporary sheltering in urban environment
Authors: Jahangiri Katayoun , Borgheipour Hasti , Gendeshmin Saeid Bahramzadeh , Matin Amirhossein , Monazami Tehrani Ghazaleh
Published: November 2019

Purpose

The inevitable occurrence of natural disasters and crisis arising from them causes a lot of losses globally, particularly in disaster-prone countries such as Iran. One of the main issues considered by organizations involved in crisis management is the selection of suitable sites for temporary sheltering for disaster victims. This study aims to choose safe places to establish temporary sheltering in urban environment.

Design/methodology/approach

Initially, relevant factors are identified by reviewing literature and through consultation with disaster experts. Next, the important layers were collected and analytical hierarchy process was used to assess the criteria weights based on their effectiveness on selection of safe sites for temporary sheltering. Finally, for integrating layers of factors, overlay and fuzzy models were used in Geographic Information System (GIS) environment, and subsequently, a proper map was prepared and suitable areas were identified.

Findings

7 main criteria and 19 sub-criteria were selected to provide safe places for temporary sheltering. The results of fuzzy model in this study provide more accurate and limited safe areas for temporary sheltering when compared to index overlay model.

Originality/value

The results of this study will help decision-makers and local and regional managers to reduce the vulnerability of at-risk communities in urban environments. Moreover, choosing appropriate places for temporary shelters would help build community disaster resilience according to these criteria.
Finite element analysis of plasticity behaviour of aluminium alloys in high-pressure torsion compressive loading stage
Authors: Lamin Fauziana , Ahmad Kamal Ariffin Ahmad Kamal Ariffin , Mohamed Intan Fadhlina
Published: November 2019

Purpose

The purpose of this paper is to examine the plasticity behaviour of aluminium alloys in high-pressure torsion (HPT) compressive loading stage. It is a part of the strengthen lightweight material development through severe plastic deformation.

Design/methodology/approach

A finite element simulation of HPT compression stage by displacement control incremental loading was proposed by taking into account an unconstraint HPT configuration. The quasi-static condition was utilised, by embedding strain hardening plasticity constitutive model and considering frictional effects, to assess the plasticity behaviour of aluminium alloys, particularly AA2024 and AA6082.

Findings

The present investigation clearly indicates that the deviation of material flow as a result of sticking condition of µ⩾0.5, was found to be negligible. An inhomogeneous material flow along the sample radial and thickness direction was evident, producing a stress concentration at the edge of the loaded surface, indicating the anticipated region of failure. The effective plastic strain in the compression stage was also found to be significant. Based on the effective strain response, plasticity behaviour of the compressed sample was predicted.

Originality/value

This paper demonstrates the plasticity behaviour of the analysed aluminium alloys. Since the mechanical properties produced by the deformed material are closely related to the exerted plastic deformation, understanding the phenomenon associated with the plastic strain development is essential. The outcome of this research will assist in seizing the opportunities of improving both material properties and the HPT procedures.
Evaluation of halal tourism in terms of bibliometric characteristics
Authors: Yagmur Yenal , Ehtiyar Rüya , Aksu Akin
Published: November 2019

Purpose

The growing competition between the developing halal market and the countries in halal market has enhanced the interest of researchers in this field in recent years. In this context, this study aims to examine the studies published in the international literature on halal tourism between 1975 and 2019 in terms of bibliometric characteristics and to reveal tendencies and trends of these publications within the framework of certain parameters.

Design/methodology/approach

In accordance with this purpose, the topic of “halal tourism” was searched in the database of “Web of Science Core Collection,” and bibliometrics data in regard to the publications were reached. Publications on halal tourism were examined in the context of years, numbers, genres, research fields, fields of study, journals in which they are found, the number of authors and page number of publications, research approaches of publications, themes of publications, country where the research data was collected (examined), names of the authors in the publications and publication numbers of the authors, and the number of citations.

Findings

In this paper, it was determined that the studies in the field of halal tourism increased in recent years. It was concluded that these studies were mainly carried out after 2011 and showed a large increase in 2016, the majority of the publications were in the form of study-paper and the average number of citations in the field was 3.1, and h-index number was seven.

Research limitations/implications

This paper is based on bibliometric analysis. Bibliometric analyses were performed on the “Web of Science Core Collection.” Because of database searches were made only on “Web of Science Core Collection,” the publications that were not scanned here could not be analyzed.

Originality/value

This paper examined the studies on halal tourism between 1975 and 2019 with a bibliometric analysis technique. Thus, it is aimed to learn more about halal tourism and to provide the researchers who work in this field with information about the structure of this field.
The determinants of imported food purchase of Muslim consumers in Malaysia
Authors: Choi YoungMin , Jeong JinYi
Published: November 2019

Purpose

This paper aims to investigate the consumption and actual purchase behaviour of Malaysian food consumers who have experienced of buying imported food and to compare the differences between two groups, Muslim and non-Muslim.

Design/methodology/approach

This study collected data from the imported food buyers in Malaysia using a self-administered questionnaire. A total of 435 usable responses were used for further analysis. To identify the Malaysian consumers’ imported food consumption, exploratory factor analysis was used. A t-test and χ2 test were applied to compare the difference of consumer groups between Muslim and non-Muslims.

Findings

The results have found the determinants of imported food purchasing of both Muslim and non-Muslim consumers and the most perceived quality aspects related to their food lifestyles. Malaysian consumers, regardless of religion, are most affected by the intrinsic factors like nutrients, health functionality and freshness. Muslim consumers also mostly perceive taste as a quality aspect regarding to their food lifestyles.

Practical implications

This study provides a number of potentially important and valuable resources for the manufacturer or exporters seeking to enter the Malaysian food market. Imported food into Malaysia should adopt the customised strategies through the products emphasising health benefits and tastes to achieve maximum marketing results.

Originality/value

This paper contributes important information about imported food consumption of Malaysian consumers. Therefore, it will be useful for food manufacturers or exporters from in particular non-Muslim countries to understand Muslim consumers’ perception and purchasing behaviour towards imported food.
Situated algorithms: a sociotechnical systemic approach to bias
Authors: Draude Claude , Klumbyte Goda , Lücking Phillip , Treusch Pat
Published: November 2019

Purpose

The purpose of this paper is to propose that in order to tackle the question of bias in algorithms, a systemic, sociotechnical and holistic perspective is needed. With reference to the term “algorithmic culture,” the interconnectedness and mutual shaping of society and technology are postulated. A sociotechnical approach requires translational work between and across disciplines. This conceptual paper undertakes such translational work. It exemplifies how gender and diversity studies, by bringing in expertise on addressing bias and structural inequalities, provide a crucial source for analyzing and mitigating bias in algorithmic systems.

Design/methodology/approach

After introducing the sociotechnical context, an overview is provided regarding the contemporary discourse around bias in algorithms, debates around algorithmic culture, knowledge production and bias identification as well as common solutions. The key concepts of gender studies (situated knowledges and strong objectivity) and concrete examples of gender bias then serve as a backdrop for revisiting contemporary debates.

Findings

The key concepts reframe the discourse on bias and concepts such as algorithmic fairness and transparency by contextualizing and situating them. The paper includes specific suggestions for researchers and practitioners on how to account for social inequalities in the design of algorithmic systems.

Originality/value

A systemic, gender-informed approach for addressing the issue is provided, and a concrete, applicable methodology toward a situated understanding of algorithmic bias is laid out, providing an important contribution for an urgent multidisciplinary dialogue.
Revising the Kano model for designing an employee compensation system
Authors: Vaez Shahrestani Hossein , Shahin Arash , Teimouri Hadi , Shaemi Barzoki Ali
Published: November 2019

Purpose

The purpose of this paper is twofold: first, to revise the Kano model with a focus on one-dimensional attributes; and second, to use the revised model for categorizing and prioritizing various employee compensation strategies.

Design/methodology/approach

The Kano evaluation table has been revised and the one-dimensional attribute has been further extended to three categories ofOO,OMandOA. In the next step, the literature review-based identified strategies have been categorized and prioritized according to the developed Kano model. Consequently, an employee compensation system has been proposed to a process-based manufacturing company as a case study.

Findings

Findings indicated that out of the 44 employee compensation strategies, typically 6 were must-be, 13 were one-dimensional, 18 were attractive and 7 were indifferent. Also, the results of the revised Kano model indicated that typically out of the 13 one-dimensional strategies, 7 were one-dimensional tending toward must-be (OM); and 6 were one-dimensional tending toward attractive (OA).

Research limitations/implications

The case study was limited to one company. The validity of the proposed model can be further studied in a larger population. This study provides managers with a more accurate instrument of decision making in selecting more differentiated employee compensation strategies, which, in turn, might lead to more employee satisfaction.

Originality/value

Theoretically, this study is different from existing studies, since almost none of the previous studies extended the Kano evaluation table for one-dimensional attributes. Practically, this study is another evidence of the application of the Kano model in the field of human resource management and in particular contributes to the design of employee compensation systems.
A review of performance-geared contracting
Authors: Odongo Nickson Herbert , Wang Daoping , Bishoge Obadia , Arrive Tsitaire Jean
Published: November 2019

Purpose

The purpose of this paper is to provide a systematic review of numerous writings addressing quality performance-geared contracting (PC) and self-stated performance.

Design/methodology/approach

The study systematically reviewed 134 refereed papers across various fields published between from 2000 to 2018. A categorization framework of PC is suggested addressing fundamental dimensions of its plan and management.

Findings

The relative analysis of pertinent articles advancing interdisciplinary perspective encourages learning and provides knowledge about quality management in organizations especially at individual and organizational levels.

Research limitations/implications

The outcomes indicate that much of the present-day wide-ranging performance contracting studies do not have robust theoretical grounds. Studies are also inclined to certain theories for instance agency theory and play down other theories with the likelihood of contributing to quality management.

Practical implications

Performance contracting between citizens and public entities is important in that the written contract limits what the public entities, for instance, the government can and cannot do and informs on the rights and privileges of citizens, thus contracts to form the core of a free society.

Originality/value

This review demonstrates that performance contracting is useful in performance improvement if proper job design and contract management exist.
Seed germination characteristics of Maianthemum dilatatum (Wood) Nels. et Macbr. (Asparagaceae)
Authors: Kawano Hitomi , Kanazawa Yumiko , Suzuki Kojiro , Ohara Masashi
Published: November 2019

The seed germination characteristics of Maianthemum dilatatum were investigated in a laboratory experiment and the results compared with those of other species in the subfamily Asparagoideae, LILIACEAE (Engler's system). M. dilatatum seeds mature in late September to October in montane to subalpine areas across Japan. Germination percentages and rates were low for fresh seeds at 10 to 30°C. Seeds cold stratified for 4 months or longer showed increased germination percentages and rates. The seeds lost germinability with decreasing moisture content. The seeds germinated well in dark conditions. The process of germination from the cotyledonary sheath/petiole breaking through the seed coat to the appearance of the first and second leaves was examined. After emergence of the cotyledonary sheath/petiole, a root emerged from it, and additional roots appeared after 1–2 months. The plumule emerged from the cotyledonary sheath/petiole after the seedling had three roots. Seeds dispersed in autumn, and germinate slowly in the next spring after exposure to low temperature even though dark condition as buried seed. We compared the seed germination characteristics among species in the Asparagoideae or with other recent taxonomy, and found that seedlings of Paris verticillate and Trillium apetalon, which belong to Melanthiaceae, and Streptopus streptopoides Var. japonica and Clintonia udensis, which belong to Liliaceae (linear cotyledon), were different from Asparagaceae, showing a globose cotyledon in the APG II.
Measuring the size of the shadow economy in 30 provinces of China over 1995–2016: The MIMIC approach
Authors: Chen Hailin , Schneider Friedrich , Sun Qunli
Published: November 2019

Applying the multiple indicators and multiple causes (MIMIC) approach, the present paper measured the size of the shadow economies in China's provinces over 1995–2016. The results show that the average size of the shadow economy in 30 provinces of China increased from 13.55% in 1995 to 14.39% in 2009, and then decreased to 12.30% in 2016. There are obvious variations in the size of the shadow economies in different districts of China. The average size of the shadow economy is lowest in provinces in the eastern district and highest in the western district. In addition, the causes and consequences of the shadow economies in China's provinces have also been analysed using the MIMIC approach, and the results show that tax burden, complexity of the tax system, intensity of regulation, unemployment, employment in the agricultural sector and economic openness have significant positive effects on China's shadow economy, while the ratio of direct taxes to indirect taxes, fiscal autonomy and income levels have significant negative effects on China's shadow economy. Using the growth rate of energy consumption as the benchmark indicator, the MIMIC analysis shows that the shadow economy has significant positive effects on the development of the official economy and income inequality while having a significant negative effect on the labour participation rate.
Sibling violence: Understanding experiences, impacts, and the need for nuanced responses
Authors: Elliott Karla , Fitz‐Gibbon Kate , Maher JaneMaree
Published: November 2019

Sibling violence is an under‐researched field, and the impact of adolescent family violence (AFV) in particular on siblings is not yet well understood. The Australian study Investigating Adolescent Family Violence in Victoria elicited responses from siblings who had experienced AFV from their brothers or sisters, as well as reflections from parents and practitioners on the difficulties of addressing AFV directed towards siblings. This article explores characteristics of sibling violence identified in this study, impacts of the violence on siblings, parents, and families, and responses to sibling violence in Victoria, Australia. Siblings described experiencing severe physical, psychological, and emotional violence, and beyond this recounted a range of difficulties such as not being believed by the adults in their lives; the violence being dismissed as normal sibling behavior; an inability to access support services without the help of parents or other adults; sadness and distress at the loss of the sibling relationship; and resentment towards parents for their perceived inaction against the violence. Practitioners highlighted the dearth of services and resources available for siblings affected by AFV, and the inadequacies of current Child Protection responses. This research sheds light on the hidden issue of sibling violence and highlights the need for nuanced responses rather than a one‐size‐fits‐all approach.
Seizures of Clandestinely Produced Tablets in Santa Catarina, Brazil: The Increase in NPS from 2011 to 2017
Authors: de Souza Júnior José Luiz , Silveira Filho Jair , Boff Bruna S. , Nonemacher Karina , Rezin Kéttulin Z. , Schroeder Samilla D. , Ferrão Marco F. , Danielli Letícia J.
Published: November 2019

Ecstasy is the name given to a large group of substances known as “club drugs” traded in the form of tablets, powder and liquid that present a varied composition, including mainly 3,4‐methylenedioxymethamphetamine (MDMA) and analogous substances, in addition to the growing presence of new psychoactive substances. Based on this, clandestinely produced tablets (“ecstasy tablets”) seized by police in Santa Catarina in the period from 2011 to 2017 were analyzed. During the study period, 3472 seizures occurred, which resulted in total 498,443 tablets seized. Seventy nine substances were identified. In the year 2011, about 90% of the tablets contained MDMA. This number decreased to 66.6% in 2017. On the other hand, there was an increase in the number of tablets that mainly contained synthetic cathinones, as well as tryptamine and piperazine derivatives. Police seizures in the metropolitan region of Florianópolis and on the coast prevailed over the rest of the state.
Review article: Primary aeromedical retrievals in Australia: An interrogation and search for context
Authors: King Jemma C , Franklin Richard C , Robertson Anita , Aitken Peter J , Elcock Mark S , Gibbs Clinton , Lawton Luke , Mazur Stefan M , Edwards Kristin H , Leggat Peter A
Published: November 2019

Primary aeromedical retrievals are a direct scene response to patients with a critical injury or illness using a medically equipped aircraft. They are often high‐acuity taskings. In Australia, information on primary retrieval taskings is housed by service providers, of which there are many across the country. This exploratory literature review aims to explore the contemporary peer‐reviewed literature on primary aeromedical retrievals in Australia. The focus is on adult primary aeromedical retrievals undertaken in Australia and clinical tools used in this pre‐hospital setting. Included articles were reviewed for research theme (clinical and equipment, systems and/or outcomes), data coverage and appraisal of the evidence. Of the 37 articles included, majority explored helicopter retrievals (n = 32), retrieval systems (n = 21), compared outcomes within a service (n = 10) and explored retrievals in the state of New South Wales (n = 19). Major topics of focus included retrieval of trauma patients and airway management. Overall, the publications had a lower strength of evidence because of the preponderance of cross‐sectional and case‐study methodology. This review provides some preliminary but piecemeal insight into primary retrievals in Australia through a localised systems lens. However, there are several areas for research action and service outcome improvements suggested, all of which would be facilitated through the creation of a national pre‐hospital and retrieval registry. The creation of a registry would enable consideration of the frequency and context of retrievals, comparison across services, more sophisticated data interrogation. Most importantly, it can lead to service and pre‐hospital and retrieval system strengthening.
Calcium transcriptionally regulates movement, recombination and other functions of Xylella fastidiosa under constant flow inside microfluidic chambers
Authors: Chen Hongyu , De La Fuente Leonardo
Published: November 2019

Xylella fastidiosa is a xylem‐limited bacterial pathogen causing devastating diseases in many economically important crops. Calcium (Ca) is a major inorganic nutrient in xylem sap that influences virulence‐related traits of this pathogen, including biofilm formation and twitching motility. This study aimed to adapt a microfluidic system, which mimics the natural habitat of X. fastidiosa, for whole transcriptome analysis under flow conditions. A microfluidic chamber with two parallel channels was used, and RNA isolated from cells grown inside the system was analysed by RNA‐Seq. Ca transcriptionally regulated the machinery of type IV pili and other genes related to pathogenicity and host adaptation. Results were compared to our previous RNA‐Seq study in biofilm cells in batch cultures (Parker et al., 2016, Environ Microbiol 18, 1620). Ca‐regulated genes in both studies belonged to similar functional categories, but the number and tendencies (up‐/downregulation) of regulated genes were different. Recombination‐related genes were upregulated by Ca, and we proved experimentally that 2 mM Ca enhances natural transformation frequency. Taken together, our results suggest that the regulatory role of Ca in X. fastidiosa acts differently during growth in flow or batch conditions, and this can correlate to the different phases of growth (planktonic and biofilm) during the infection process.
Response of Nitrogen Loading to the Chesapeake Bay to Source Reduction and Land Use Change Scenarios: A SPARROW‐Informed Analysis
Authors: Miller Matthew P. , Capel Paul D. , García Ana María , Ator Scott W.
Published: November 2019

In response to concerns regarding the health of streams and receiving waters, the United States Environmental Protection Agency established a total maximum daily load for nitrogen in the Chesapeake Bay watershed for which practices must be in place by 2025 resulting in an expected 25% reduction in load from 2009 levels. The response of total nitrogen (TN) loads delivered to the Bay to nine source reduction and land use change scenarios was estimated using a Spatially Referenced Regression on Watershed Attributes model. The largest predicted reduction in TN load delivered to the Bay was associated with a scenario in which the mass of TN as fertilizer applied to agricultural lands was decreased. A 25% decrease in the mass of TN applied as fertilizer resulted in a predicted reduction in TN loading to the Bay of 11.3%, which was 2.5–5 times greater than the reductions predicted by other scenarios. Eliminating fertilizer application to all agricultural land in the watershed resulted in a predicted reduction in TN load to the Bay of 45%. It was estimated that an approximate 25% reduction in TN loading to the Bay could be achieved by eliminating fertilizer applied to the 7% of subwatersheds contributing the greatest fertilizer‐sourced TN loads to the Bay. These results indicate that management strategies aimed at decreasing loading from a small number of subwatersheds may be effective for reducing TN loads to the Bay, and similar analyses are possible in other watersheds.
A randomized clinical study to compare intrapleural infusion with intravenous infusion of bevacizumab in the management of malignant pleural effusion in patients with non‐small‐cell lung cancer
Authors: Nie Keke , Zhang Zhen , You Yunhong , Zhuang Xingjun , Zhang Chunling , Ji Youxin
Published: November 2019

Background

To compare the efficiency and toxicity of bevacizumab by intrapleural or intravenous infusion in the management of malignant pleural effusion in patients with non‐small‐cell lung cancer (NSCLC).

Methods

Sensitizing mutation negative NSCLC patients with malignant pleural effusion were randomized into two groups in 1:1 ratio. The pleural effusion was completely drained in 24 hours; one group received intrapleural infusion and the second group received intravenous infusion of bevacizumab at a dose of 7.5 mg per kg bodyweight. The serum vascular endothelial growth factor (VEGF) was tested before and 72 hours after injection of bevacizumab. Computerized tomography (CT) scan to evaluate pleural effusions was carried out at four weeks for each patient and their survival followed‐up.

Results

A total of 67 patients were screened and 43 enrolled into the study. The response rate was 80% (16 of 20) in the intrapleural group and 66.7% (14 of 21) in the intravenous group. The median duration of response (DoR) of pleural effusion was 4.50 months and 3.70 months, respectively. The median serum VEGF level at 72 hours decreased 67.25% in the intrapleural group and 57.19% in the intravenous group compared to baseline level (P = 0.276). The median serum VEGF level at 72 hours decreased 52.02% compared to baseline level in patients’ DoR less than three months and 68.33% in patients' DoR longer than three months, respectively (P = 0.014). The main side effects noted were mild to moderate hypertension, proteinuria and epistaxis.

Conclusions

Bevacizumab intrapleural infusion had higher efficiency and higher safety than intravenous infusion in the management of malignant pleural effusion caused by NSCLC. The decreased level of serum VEGF at 72 hours after bevacizumab treatment was closely related to the response rate and duration of the response of pleural effusion.
Depressed demand for crop insurance contracts, and a rationale based on third generation Prospect Theory
Authors: Feng Hongli , Du Xiaodong , Hennessy David A.
Published: November 2019

When actuarially fair insurance for a major risk is available then standard economic theory posits that those subject to the risk should insure. In agriculture, it is common for producers to decline contract offers where presubsidy premiums just cover average losses and subsidies are substantial. This paper seeks to shed light on why demand is curtailed. In a mail survey of U.S. corn and soybean producers we solicited Willingness to Pay (WTP) for actuarially fair insurance at different coverage levels. We find demand to be so low that median WTP is no larger than fair premium when adjusted down by current subsidy rates, which pay for one half or more of most premium charges. WTP as a share of the fair rate is especially low when risk of loss is high. There is limited evidence that respondents appreciate the convex relationship between coverage level and expected indemnity payoff. Third generation Prospect Theory is shown to be consistent with observed findings. In particular, a strong distaste for paying premium can be rationalized by loss aversion. Furthermore, when high revenue outcomes are more likely than not, that is, negative skewness, then higher loss aversion, greater decision weight distortions and greater risk aversion will decrease WTP.
The tempo of puberty and its relationship to adolescent health and well‐being: A systematic review
Authors: Cheng Hoi Lun , Harris Stella R. , Sritharan Myuran , Behan Matthew J. , Medlow Sharon D. , Steinbeck Katharine S.
Published: November 2019

Aim

Emerging evidence suggests that pubertal tempo, that is rate of passage through puberty, has relevance to adolescent mood and behaviour. However, its wider health and developmental significance remain unclear. This systematic review sought to clarify the relationship of pubertal tempo to indicators of health and development, and to document tempo definitions and pubertal durations reported in the literature.

Methods

Eight electronic databases were searched from earliest record to July 2018. Study eligibility: healthy participants; age 8‐21 years; ≥2 longitudinal measures of puberty; analysis of tempo against a health or developmental indicator.

Results

Thirty‐eight studies met eligibility, and these reported on diverse tempo definitions and seven health‐ and development‐related domains. Data sets with varying tempo definitions converged on an association of rapid pubertal progression to: (a) higher adiposity during childhood and adolescence in both sexes; and (b) lower psychosocial well‐being in adolescent males. Later thelarche unanimously predicted faster progression to menarche in females, but this compensation was largely undetected when alternate definitions of pubertal timing and/or tempo were used. Duration of puberty ranged from 2.5‐4.1 years.

Conclusion

Pubertal tempo may be clinically relevant when considering trajectories of adiposity and psychosocial well‐being among adolescents, especially males. Consensus on the definition of tempo would facilitate between‐study comparisons.
Physical Activity in Peri‐Urban Communities: Testing Intentional and Implicit Processes within an Ecological Framework
Authors: Olson Jenny L. , Ireland Michael J. , March Sonja , Biddle Stuart J. H. , Hagger Martin S.
Published: November 2019

Background

Given the substantive health inequalities in peri‐urban communities and the potential for physical activity to promote health in these communities, identifying modifiable physical activity determinants in this population is important. This study explored effects of the peri‐urban environment and psychological constructs on physical activity intentions and behavioural automaticity guided by an integrated theoretical framework.

Methods

Peri‐urban Australians (N = 271) completed self‐report measures of environmental (i.e. physical/social environment, and neighbourhood selection), motivational (i.e. autonomous motivation), and social cognition (i.e. attitudes, norms, and perceived behavioural control [PBC]) constructs, past behaviour, intentions, and automaticity.

Results

A well‐fitting path analytic model revealed that: autonomous motivation predicted all social cognition constructs; subjective norms and PBC, but not attitudes; autonomous motivation predicted intentions and automaticity; and subjective norms and PBC mediated effects of autonomous motivation on intentions. Of the environmental constructs, only neighbourhood selection was related to intentions, mediated by PBC.

Conclusions

Autonomous motivation is an important correlate of physical activity intentions and automaticity, and subjective norms and PBC also related to intentions. Individuals perceiving a supportive environment were more likely to report positive PBC and intentions. Targeting change in autonomous motivation, and normative and control beliefs may help enhance physical activity intentions and automaticity in peri‐urban communities.
Investigating the dietary life histories and mobility of children buried in St Gertrude Church cemetery, Riga, Latvia, 15th–17th centuries ad*
Authors: Petersone‐Gordina E. , Montgomery J. , Millard A. R. , Roberts C. , Gröcke D. R. , Gerhards G.
Published: November 2019

Carbon and nitrogen isotope profiles were obtained from incremental dentine analysis of 19 non‐adults from a cemetery in Riga, Latvia. The research compared the life histories and diet between people buried in two mass graves and the general cemetery. The δ13C profiles of several children from the mass graves were similar but did not resemble the patterns seen in children from the general cemetery, suggesting that they probably represented a different population group. The rise in δ15N values towards the end of the life of four individuals from one mass grave suggests they were victims of an historically documented famine.
Time to start intervening in the human germline? A utilitarian perspective
Authors: Smith Kevin
Published: November 2019

Focusing on present‐day possibilities raised by existing technology, I consider the normative aspects of genetically modifying the human germline from a utilitarian standpoint. With reference to a hypothetical case, I examine the probable consequences of permitting a well‐conceived attempt to correct a disease‐associated gene in the human germline using current CRISPR gene‐editing technology. I consider inter alia the likely effects on utility of creating healthy new lives, of discouraging adoption, and of kickstarting a revolution in human germline genetic modification (HGGM). I reject various objections to HGGM, including claims that the risks of genetic harm outweigh the likely benefits. From this utilitarian analysis, I conclude that strong grounds exist to support intervening in the human germline using current technology. Delay in commencing such work will impose a utility cost, because the longer we wait until commencing the HGGM revolution and moving towards a world of increased utility, the greater will be the quantity of suffering accrued meantime through genetically influenced disease. Nevertheless, considering residual safety concerns and the negative publicity engendered by an ethically problematic recent (2018) first attempt at HGGM, it seems prudent—and ultimately generative of the greatest amount of utility—to delay implementing HGGM for a modest period of time, in the order of 1–2 years.
What are the perspectives of adolescents with Down syndrome about their quality of life? A scoping review
Authors: Sheridan Ciara , OMalley‐Keighran Mary‐Pat , Carroll Clare
Published: November 2019

Accessible summary

This study looked for information about the quality of life of adolescents with Down syndrome.

We found two studies about quality of life that included the voice of the adolescent with Down syndrome. Most of the research includes parents’ voices. Parents’ views are important, but we need to also include adolescents with Down syndrome in research about their lives.

Friends, family and independence are important to adolescents with Down syndrome.

More information on quality of life is needed to help us understand more about their individual needs.

Background

There is a wealth of research on adolescents with Down syndrome (DS) covering a large range of topics such as obesity, speech and language, education and health‐related quality of life. However, for quality of life, much of the available literature for adolescents with DS relies on parent proxy reporting. This results in more research on parent's perspectives rather than from the individuals with DS themselves.

Aim

This study aimed to examine the literature to identify the literature that included the voice of adolescents with DS in research about quality of life. It aimed to address the research question: What evidence exists in relation to the perspectives of adolescents with DS about their quality of life?

Method

A scoping review allowed for an extensive range of research and nonresearch material to be gathered. Search terms were identified, followed by searches of five electronic databases, Google scholar and Lenus (Irish Health Repository). Two researchers conducted the review. Studies were selected through inclusion/exclusion criteria. A chart summarised information from the selected studies.

Results

A total of 596 articles were marked for title and abstract screening. Forty‐five articles were included for full‐text review. Forty‐three of these met exclusion criteria, resulting in two articles which included the voices of adolescents with DS themselves. For adolescents with DS, participation socially and in their communities was important as well as friendships, family relationships and functional independence. These themes need to be further explored.

Conclusion

The UN Convention on the Rights the Person with Disabilities argues strongly for participation (United Nations [2006], UN convention on the rights of persons with disabilities). This paper highlights the lack of and need for further empirical quality‐of‐life research with adolescents with DS from their own perspectives.