bluuebunny/crossref_metadata_2025 huggingface dataset:
From 1D Coordination Polymers to Metal Organic Frameworks by the Use of 2-Pyridyl Oximes
Authors: Mylonas-Margaritis Ioannis , Gérard Auban , Skordi Katerina , Mayans Julia , Tasiopoulos Anastasios , McArdle Patrick , Papatriantafyllopoulou Constantina
Published: September 2020

The synthesis and characterization of coordination polymers and metal–organic frameworks (MOFs) has attracted a significant interest over the last decades due to their fascinating physical properties, as well as their use in a wide range of technological, environmental, and biomedical applications. The initial use of 2-pyridyl oximic ligands such as pyridine-2 amidoxime (H2pyaox) and 2-methyl pyridyl ketoxime (Hmpko) in combination with 1,2,4,5-benzene tetracarboxylic acid (pyromellitic acid), H4pma, provided access to nine new compounds whose structures and properties are discussed in detail. Among them, [Zn2(pma)(H2pyaox)2(H2O)2]n (3) and [Cu4(OH)2(pma)(mpko)2]n (9) are the first MOFs based on a 2-pyridyl oxime with 9 possessing a novel 3,4,5,8-c net topology. [Zn2(pma)(H2pyaox)2]n (2), [Cu2(pma)(H2pyaox)2(DMF)2]n (6), and [Cu2(pma)(Hmpko)2(DMF)2]n (8) join a small family of coordination polymers containing an oximic ligand. 9 exhibits selectivity for FeIII ions adsorption, as was demonstrated by a variety of techniques including UV-vis, EDX, and magnetism. DC magnetic susceptibility studies in 9 revealed the presence of strong antiferromagnetic interactions between the metal centers, which lead to a diamagnetic ground state; it was also found that the magnetic properties of 9 are affected by the amount of the encapsulated Fe3+ ions, which is a very desirable property for the development of magnetism-based sensors.
Diversity of Conopeptides and Their Precursor Genes of Conus Litteratus
Authors: Li Xinjia , Chen Wanyi , Zhangsun Dongting , Luo Sulan
Published: September 2020

The venom of various Conus species is composed of a rich variety of unique bioactive peptides, commonly referred to as conotoxins (conopeptides). Most conopeptides have specific receptors or ion channels as physiologically relevant targets. In this paper, high-throughput transcriptome sequencing was performed to analyze putative conotoxin transcripts from the venom duct of a vermivorous cone snail species, Conus litteratus native to the South China Sea. A total of 128 putative conotoxins were identified, most of them belonging to 22 known superfamilies, with 43 conotoxins being regarded as belonging to new superfamilies. Notably, the M superfamily was the most abundant in conotoxins among the known superfamilies. A total of 15 known cysteine frameworks were also described. The largest proportion of cysteine frameworks were VI/VII (C-C-CC-C-C), IX (C-C-C-C-C-C) and XIV (C-C-C-C). In addition, five novel cysteine patterns were also discovered. Simple sequence repeat detection results showed that di-nucleotide was the major type of repetition, and the codon usage bias results indicated that the codon usage bias of the conotoxin genes was weak, but the M, O1, O2 superfamilies differed in codon preference. Gene cloning indicated that there was no intron in conotoxins of the B1- or J superfamily, one intron with 1273–1339 bp existed in a mature region of the F superfamily, which is different from the previously reported gene structure of conotoxins from other superfamilies. This study will enhance our understanding of conotoxin diversity, and the new conotoxins discovered in this paper will provide more potential candidates for the development of pharmacological probes and marine peptide drugs.
Exploring the Effect of Training in Visual Block Programming for Preservice Teachers
Authors: Sáez-López José Manuel , del Olmo-Muñoz Javier , González-Calero José Antonio , Cózar-Gutiérrez Ramón
Published: September 2020

This study evaluates the effectiveness of visual block programming-based instruction and its possibilities in the training of future teachers. In particular, the application Scratch, a visual programming environment, was employed to introduce pre-service teachers to programming. The study followed a mixed-method design with a sample of 79 pre-service teachers. A quantitative approach was used to evaluate the gains in the participants’ knowledge of computational concepts and attitudes towards Scratch as a pedagogic tool. A qualitative analysis aimed at evaluating the participants’ knowledge concerning programming applications, and their perception about possible difficulties in the implementation of programming in educational contexts. Positive results were obtained for programming in the classroom, with significant improvements in innovation, collaboration, active learning, motivation, and fun for the students. After the experiment, the subjects highlighted Scratch as a fundamental block programming tool and the need for teacher training in this field. The need to improve the implementation of visual block programming in Education Degree curricula is supported.
Evolution of International Psychiatry
Authors: Girardi Paolo , Bonanni Luca , Kotzalidis Georgios D. , Fiaschè Federica , Del Casale Antonio
Published: September 2020

International psychiatry is currently facing serious challenges triggered by the global economic crisis and the COVID-19 pandemic. These global events lead to the need to broaden our nosographic and therapeutic horizons, and to make use of the newest psychological approaches and the latest neuroscience acquisitions. The focus should be on the psychological consequences of the pandemic, not only on people suffering from mental disorders, but also on the general population, for which the risk of developing psychic symptoms appears to be increased. A population that needs special attention is that of health workers involved in the management of the pandemic. In facing these problems, psychiatry today can use numerous new clinical applications and technologies in the fields of precision medicine. These include genomics, neuroimaging, and microbiomics, which can also be integrated with each other through machine learning systems. They can provide new contributions both in treatment personalization and in the evolution of nosographic systems. Besides this, the contribution of psychotherapies and dynamic and clinical psychology appears to be indispensable for a complete understanding of the clinical and personological aspects of patients. This journal aims to include innovative studies deriving from original, clinical, and basic research in the fields of mental health, precision psychiatry, genomics, neuroimaging, neuropsychopharmacology, and dynamic and clinical psychology.
God Spots in the Brain: Nine Categories of Unasked, Unanswered Questions
Authors: Klemm W. R.
Published: September 2020

Neurotheology is an emerging academic discipline that examines mind-brain relationships in terms of the inter-relatedness of neuroscience, spirituality, and religion. Neurotheology originated from brain-scan studies that revealed specific correlations between certain religious thoughts and localized activated brain areas known as “God Spots.” This relatively young scholarly discipline lacks clear consensus on its definition, ideology, purpose, or prospects for future research. Of special interest is the consideration of the next steps using brain scans to develop this field of research. This review proposes nine categories of future research that could build on the foundation laid by the prior discoveries of God Spots. Specifically, this analysis identifies some sparsely addressed issues that could be usefully explored with new kinds of brain-scan studies: neural network operations, the cognitive neuroscience of prayer, biology of belief, measures of religiosity, role of the self, learning and memory, religious and secular cognitive commonalities, static and functional anatomy, and recruitment of neural processing circuitry. God Spot research is poised to move beyond observation to robust hypothesis generation and testing.
Numerical Model of SPAD-Based Direct Time-of-Flight Flash LIDAR CMOS Image Sensors
Authors: Tontini Alessandro , Gasparini Leonardo , Perenzoni Matteo
Published: September 2020

We present a Montecarlo simulator developed in Matlab® for the analysis of a Single Photon Avalanche Diode (SPAD)-based Complementary Metal-Oxide Semiconductor (CMOS) flash Light Detection and Ranging (LIDAR) system. The simulation environment has been developed to accurately model the components of a flash LIDAR system, such as illumination source, optics, and the architecture of the designated SPAD-based CMOS image sensor. Together with the modeling of the background noise and target topology, all of the fundamental factors that are involved in a typical LIDAR acquisition system have been included in order to predict the achievable system performance and verified with an existing sensor.
A Distributed Computing Solution Based on Distributed Kalman Filter for Leak Detection in WSN-Based Water Pipeline Monitoring
Authors: Nkemeni Valery , Mieyeville Fabien , Tsafack Pierre
Published: September 2020

Wireless Sensor Network (WSN) applications that favor more local computations and less communication can contribute to solving the problem of high power consumption and performance issues plaguing most centralized WSN applications. In this study, we present a fully distributed solution, where leaks are detected in a water distribution network via only local collaborations between a sensor node and its close neighbors, without the need for long-distance transmissions via several hops to a centralized fusion center. A complete approach that includes the design, simulation, and physical measurements, showing how distributed computing implemented via a distributed Kalman filter improves the accuracy of leak detection and the power consumption is presented. The results from the physical implementation show that distributed data fusion increases the accuracy of leak detection while preserving WSN lifetime.
Identifying Facemask-Wearing Condition Using Image Super-Resolution with Classification Network to Prevent COVID-19
Authors: Qin Bosheng , Li Dongxiao
Published: September 2020

The rapid worldwide spread of Coronavirus Disease 2019 (COVID-19) has resulted in a global pandemic. Correct facemask wearing is valuable for infectious disease control, but the effectiveness of facemasks has been diminished, mostly due to improper wearing. However, there have not been any published reports on the automatic identification of facemask-wearing conditions. In this study, we develop a new facemask-wearing condition identification method by combining image super-resolution and classification networks (SRCNet), which quantifies a three-category classification problem based on unconstrained 2D facial images. The proposed algorithm contains four main steps: Image pre-processing, facial detection and cropping, image super-resolution, and facemask-wearing condition identification. Our method was trained and evaluated on the public dataset Medical Masks Dataset containing 3835 images with 671 images of no facemask-wearing, 134 images of incorrect facemask-wearing, and 3030 images of correct facemask-wearing. Finally, the proposed SRCNet achieved 98.70% accuracy and outperformed traditional end-to-end image classification methods using deep learning without image super-resolution by over 1.5% in kappa. Our findings indicate that the proposed SRCNet can achieve high-accuracy identification of facemask-wearing conditions, thus having potential applications in epidemic prevention involving COVID-19.
DeepBrain: Experimental Evaluation of Cloud-Based Computation Offloading and Edge Computing in the Internet-of-Drones for Deep Learning Applications
Authors: Koubaa Anis , Ammar Adel , Alahdab Mahmoud , Kanhouch Anas , Azar Ahmad Taher
Published: September 2020

Unmanned Aerial Vehicles (UAVs) have been very effective in collecting aerial images data for various Internet-of-Things (IoT)/smart cities applications such as search and rescue, surveillance, vehicle detection, counting, intelligent transportation systems, to name a few. However, the real-time processing of collected data on edge in the context of the Internet-of-Drones remains an open challenge because UAVs have limited energy capabilities, while computer vision techniquesconsume excessive energy and require abundant resources. This fact is even more critical when deep learning algorithms, such as convolutional neural networks (CNNs), are used for classification and detection. In this paper, we first propose a system architecture of computation offloading for Internet-connected drones. Then, we conduct a comprehensive experimental study to evaluate the performance in terms of energy, bandwidth, and delay of the cloud computation offloading approach versus the edge computing approach of deep learning applications in the context of UAVs. In particular, we investigate the tradeoff between the communication cost and the computation of the two candidate approaches experimentally. The main results demonstrate that the computation offloading approach allows us to provide much higher throughput (i.e., frames per second) as compared to the edge computing approach, despite the larger communication delays.
Disruptive Technologies in Smart Cities: A Survey on Current Trends and Challenges
Authors: Radu Laura-Diana
Published: September 2020

This paper aims to explore the most important disruptive technologies in the development of the smart city. Every smart city is a dynamic and complex system that attracts an increasing number of people in search of the benefits of urbanisation. According to the United Nations, 68% of the world population will be living in cities by 2050. This creates challenges related to limited resources and infrastructure (energy, water, transportation system, etc.). To solve these problems, new and emerging technologies are created. Internet of Things, big data, blockchain, artificial intelligence, data analytics, and machine and cognitive learning are just a few examples. They generate changes in key sectors such as health, energy, transportation, education, public safety, etc. Based on a comprehensive literature review, we identified the main disruptive technologies in smart cities. Applications that integrate these technologies help cities to be smarter and offer better living conditions and easier access to products and services for residents. Disruptive technologies are generally considered key drivers in smart city progress. This paper presents these disruptive technologies, their applications in smart cities, the most important challenges and critics.
Effect of Intraocular Lens Tilt and Decentration on Visual Acuity, Dysphotopsia and Wavefront Aberrations
Authors: Ashena Zahra , Maqsood Sundas , Ahmed Syed Naqib , Nanavaty Mayank A.
Published: September 2020

Tilt and decentration of intraocular lenses (IOL) may occur secondary to a complicated cataract surgery or following an uneventful phacoemulsification. Although up to 2–3° tilt and a 0.2–0.3 mm decentration are common and clinically unnoticed for any design of IOL, larger extent of tilt and decentration has a negative impact on the optical performance and subsequently, the patients’ satisfaction. This negative impact does not affect various types of IOLs equally. In this paper we review the methods of measuring IOL tilt and decentration and focus on the effect of IOL tilt and decentration on visual function, in particular visual acuity, dysphotopsia, and wavefront aberrations. Our review found that the methods to measure the IOL displacement have significantly evolved and the available studies have employed different methods in their measurement, while comparability of these methods is questionable. There has been no universal reference point and axis to measure the IOL displacement between different studies. A remarkably high variety and brands of IOLs are used in various studies and occasionally, opposite results are noticed when two different brands of a same design were compared against another IOL design in two studies. We conclude that <5° of inferotemporal tilt is common in both crystalline lenses and IOLs with a correlation between pre- and postoperative lens tilt. IOL tilt has been noticed more frequently with scleral fixated compared with in-the-bag IOLs. IOL decentration has a greater impact than tilt on reduction of visual acuity. There was no correlation between IOL tilt and decentration and dysphotopsia. The advantages of aspheric IOLs are lost when decentration is >0.5 mm. The effect of IOL displacement on visual function is more pronounced in aberration correcting IOLs compared to spherical and standard non-aberration correcting aspherical IOLs and in multifocal versus monofocal IOLs. Internal coma has been frequently associated with IOL tilt and decentration, and this increases with pupil size. There is no correlation between spherical aberration and IOL tilt or decentration. Although IOL tilt produces significant impact on visual outcome in toric IOLs, these lenses are more sensitive to rotation compared to tilt.
Groundwater Response of Loess Tableland in Northwest China under Irrigation Conditions
Authors: Dai Fuchu , Guo Qinghua
Published: September 2020

Water induced loess landslides are closely related to the rise of the groundwater level. Therefore, research on the response of the groundwater level to irrigation water holds promise for revealing the mechanism of water-induced loess landslide. Taking Heitai, Gansu Province, as the research area, a coupling model o unsaturated-saturated water movement is established using the HYDRUS-MODFLOW software. The parameters of the model are calibrated and verified by the Bayesian parameter inversion method combined with field observations of the groundwater level. Finally, the change in the groundwater level under different irrigation amounts is predicted using the optimized model. It is found that a reasonable reduction of the irrigation amount can effectively slow the rise of the groundwater level. This research provides a scientific reference for the development of reasonable irrigation measures.
Reductionism and holism in the philosophy of medicine
Authors: Zakablukovskiy E.
Published: September 2020

The article highlights certain aspects of the discussion on the topic of reductionism vs. holism in the philosophy of medicine. Classic radical reductionism is defeated by the concept of emergence. The s.c. bio-medical point of view on a malady, despite its relevance and clear benefit, is not recognized as universal as its adherents may claim, and it yields to an integral psycho-bio-social model. The author introduces a new classification of holism (vitalistic, social and individualistic) and makes appropriate recommendations to clinicians. It is social holism at the macro level that has proven effective in combating the spread of COVID-19.
Quality and safety of dry protein and carbohydrate composite based on HACCP principles
Authors: Motovilov K. , Volonchuk S. , Naumenko I. , Rezepin A.
Published: September 2020

Creating complete feed for cattle especially during the period of indoor housing is an important task of feed production. This determines the increase in milk yield and live weight, and the profitability of all production. Biotechnology of obtaining a combined feed additive in the form of a dry protein and carbohydrate composite for animals from plant raw materials and secondary raw materials allows us to solve this problem. At the same time, the quality and safety of the composite is an extremely relevant topic. In the course of research the influence of technological factors control, based on the principles of HACCP, on the quality and safety indicators of the combined feed additive has been established. The resulting product according to organoleptic indicators is a loose mixture of no more than 5–8 mm in size, without solid inclusions, foreign impurities and fumes; color is from gray to brown; smell is characteristic of the set of components included in the recipe, without musty, mold and other odors. Physical and chemical parameters are as follows: mass fraction of moisture no more than 14 %; mass fraction of sugars is at least 27–30 %; mass fraction of protein is 17,6–18,4 %, fiber content is 7,0–7,3 %. Safety indicators: total number of fungi (CFU/g) no more than 5×10[sup]4[/sup] ; total microbial number (CFU/g) no more than 5×10[sup]5[/sup] . The presence of Salmonella in 25 g is not allowed; the presence of pathogenic Escherichia in 1,0 g is not allowed. The remaining safety indicators, due to their invariability in the process of technological operations, must comply with the indicators provided for in the normative documents for raw materials. Five control critical points in the technology of proteincarbohydrate composite production that pose a threat to its quality and safety have been identified. It has been shown that the preliminary assessment and proposed corrective actions for managing hazards at all stages of the production process, which significantly affect the safety of products, can prevent the appearance of a danger of deviations from the parameters of the technological process at each stage of production.
Press granulators, technical features, influence of granulation on qualitative characteristics of feed
Authors: Blagov D. , Mitrofanov S. , Panfyorov N. , Teterin V. , Pestryakov E.
Published: September 2020

An important task for any farming enterprise producing animal products is to provide feed with high nutritional value for the animals. At the same time in addition to growing and preserving feed of their own production, farms purchase, including food processing products: brewing waste, beetroot pulp, brewer’s grains, etc. These wastes are usually delivered in liquid form and have a low nutritional value and shelf life, as well as a high specific cost of transportation. One of the solutions to this problem is the use of granulation technology. The main types of press granulators, their design features and operating principles, as well as the materials of scientific researches aimed at studying the properties of granulated feed have been described in the article. Thus, according to the materials studied, the use of press granulators in the process of processing food waste allows to achieve an increase in their nutritional value and shelf life of feed. Analysis of the use of granulated feed in the diet of animals has shown their better digestibility compared to feed presented in crumbled form, which contributed to an increase in productivity in animals. Thus, we can conclude that the use of press granulators in the process of feed preparation of various designs is a promising direction of production. At the same time, the choice of the granulator should be based on its technical features and performance. So, for a small agricultural enterprise, fl at-matrix granulators with a capacity of up to 1000 kg/h are suitable.
Sensitivity Analysis and Simulation of TEG Dehydration Unit in Central Rumaila Compression Station in Basrah-Iraq
Authors: Khalaf Ali
Published: September 2020

In the operating of TEG- dehydration unit in CentralRumaila Compression Station. Two operating parametersdetermine the efficient operating of the unit, the desired dewpoint depression and the losses of TEG. This work presents anattempt to study the effect of all the operating variables on theefficiency of the dehydration unit such as the effect of pressureand temperature of the natural gas has to be treated on thewater content. Contactor pressure, TEG circulating rate andstripping gas flow rate are also considered in this study. Theresults showed that decreasing the temperature of the absorberfrom 130 F to 120 F will reduce the mass fraction of water inthe dry gas stream from 0.000076 to 0.00002. Increasing theabsorber pressure from 549.7 psia (design pressure) to 600 psiawill also reduce the water content in the outlet dry gas from0.000076 to 0.000022 as a mass fraction. The simulation resultshows a linear relationship between the wet gas flow rate from theregeneration column and the lean glycol flow rate.
A Chaotic Crow Search Algorithm for High-Dimensional Optimization Problems
Authors: Tahir Dunia , Ali Ramzy
Published: September 2020

Crow Search Algorithm is an innovative metaheuristic optimization algorithm. In this paper, chaotic mapsare combined into Crow Search Algorithm to increase itsglobal optimization. Ten variant chaotic maps are used and theTent map is found as the best choices for high dimensionalproblems. The novel Chaotic Crow Search Algorithm is reliedon the substitution of a random location of search space andthe awareness parameter of crow with chaotic sequences. Theresults show that the chaotic maps are able to enhance theperformance of the Crow Search Algorithm. Also the novelChaotic Crow Search Algorithm outperforms the conventionalCrow Search Algorithm, the first version of Chaotic Crow SearchThe algorithm, Genetic Algorithm, and Particle SwarmOptimization Algorithm from the point of view of the speedconvergence and the function dimensions.
Energy and Exergy Analysis of Rumaila-Basra Gas Turbine Power Plant During Hot Sea
Authors: Faisal Safaa , Al.Mudhaffar Mujtaba , Khetar Ali
Published: September 2020

In this paper, energy and exergy concepts have beencarried out on one of the largest gas turbine power plants inIraq (Rumaila-Basra). Both ISO operating conditions as wellas actual operating data recorded for one month in hot seasonare considered. Results indicate that a lot of heat energyaccompanied with remarkable exergy is discharged to theatmosphere. Also, it is found that the combustion chamber hasthe largest exergy destruction among the plant components.The possibility of cooling the intake air drawn by the compressorand its effects on the plant performance is studied. Therequired cooling load is found to be in the range 3379 T.R forpart load operation to 4723.3 T.R for full load operation.
Energy-Exergy Performance Comparison of an Ideal Vapor Compression Refrigeration Cycle using Alternatives Refrigerants of R134a for Low Potential of Global Warming
Authors: AlSayyab Ali
Published: September 2020

This work presents a theoretical study on theapplication of low global warming refrigerants as an alternativerefrigerant to R 134a in a refrigeration system. Therefrigerants investigated are R1234yf, R1234ze, R245fa andR227ea. The performance characteristics of the refrigerationsystem were predicted using mathematical models running byusing EES program under different condenser and evaporatortemperatures. The results show that at any working conditionthe R1234ze give an identical performance to R134a and can beused as the best low global warming alternative refrigerant. Sothe compressor work with R1234ze should be designed withdisplacement volume more than that of R134a to overcome thereduction in mass flow rate.
Gypsum Content Horizontal and Vertical Distribution of An-Najaf and Al-Kufa Cities' Soil by Using GIS
Authors: Almamoori Sohaib
Published: September 2020

An-Najaf province considered one of the mostimportant cities in Iraq, which is facing rapid populationgrowth and continuous development in constructions such ashousing, hotels, bridges and shopping malls. Therefore, thisstudy aims to create a database for the gypsum content in AnNajaf province (Najaf center and Al-Kufa city). To evaluatethe spatial variability of gypsum content, 464 boreholes and insitu tests were selected and analyzed using GeographicInformation System (GIS). To achieve that, the adoptedmethod consisted of four steps: (1) data collection; (2)geotechnical data georeferencing; (3) interpolation methodsand (4) establishment of maps. Nine geotechnical maps wereproduced for depths (0, 2, 4, 6, 8, 10, 12, 14, 16, and 35) m.Results showed that the largest part of the study area for thedepths from 0-4 m had a gypsum content ranged between 10-25% (moderately gypsiferous), whereas the depths from 4-8 mhad a gypsum content ranged between 3-10% (slightlygypsiferous), and the depths from 8-35 m had a gypsumcontent ranged between 0.3-3% (very slightly gypsiferous).This concludes that the layers from 0-4 m are exceeding theallowed limits (10% gypsum content), which may affect thestability of constructions due to the high levels of groundwaterin Najaf province.
The role of endoscopic ultrasound in staging of esophageal cancer
Authors: Kieu Thi Phuong Nhan , Tran Van Huy
Published: September 2020

Objective: To determine features of endoscopic ultrasound in esophageal cancer and relation with clinic, endoscopy and computerized tomography.

Patients and methods: A cross-sectional study was conducted on 40 patients indicated for endoscopic ultrasound to staging esophageal cancer.

Results: The total number of patients studied in study were 40. The middle and lower 1/3rd of esophagus affected more commonly compare to other parts. Mean length of tumor in endoscopy was 5.19 ± 2.37cm. The majority of patients presented late with advanced stage of cancer in endoscopy (90%). Squamous cell carcinoma (95%) was the most common histopathological type. CT/TNM staging was documented in 33 (82.5%) patients: T1 (3.1%), T2 (25%), T3 (53.1%), T4a (12.5%), T4b (6.3%), N0 (30.3%). Staging by ultrasonoscopy: Tis (2.5%), T1a (5%), T1b (0), T2 (7.5%), T3 (42.5%), T4a (32.5%), T4b (10%). The predictive value of tumor length was significant in patients with N0 or lympho node status (p = 0.003).

Conclusions: Endoscopic ultrasound improved the diagnostic accuracy of esophageal cancer staging.

Key words: endoscopic ultrasound, esophageal cance
Bladder dysfunction in women with diabetes mellitus
Authors: Hoang Thi Bich Ngoc , Nguyen Hai Thuy
Published: September 2020

Introduction: Lower urinary tract dysfunctions secondary to type 2 DM are common, chronic and costly disorders. The incidence of diabetic bladder dysfunction was estimated range between 43% and 87% for type 1 and 25% for type 2 diabetes. Ultrasonography is an easy-to-use, fast, safe, non-invasive, painless, pleasant and valuable method of assessing Bladder Post-Void Residual Volume (PVR).

Aim: To investigate prevalence of bladder dysfunction and its relation with risk factors, clinical features of diabetic cystopathy in women with diabetes, to identify the values predicting to have postvoid residual volume of the risk factors.

Methods: A cross sectional descriptive study, a cohort of 84 female inpatients and outpatients with diabetes mellitus who were treated at Hue University of Medicine and Pharmacy Hospital from 08/2017 to 08/2019 and 84 healthy control subjects were enrolled, the patients were carried out clinical finding, taken blood tests, and estimated postvoid residual volume using 2D ultrasound.

Results: the postvoid residual volume was presented in 67 cases (79.80%), the clinical symptoms of diabetic cystopathy were reported in 75% of women with diabetes. Blood glucose, HbA1c, clinical symptoms of diabetic cystopathy, postural hypotension and diabetic peripheral neuropathy were associated with postvoid residual volume. The HbA1c level had a great capability to predict who had postvoid residual volume, at HbA1c cutoff value of 9.1%, Se 65.67%, Sp 94.12%, AUC 0.811, p < 0.001. Conclusion: Bladder dysfunction made up a highly prevalent in women with poor glycemic control.

Key words: bladder dysfunction, diabetic cystopathy, bladder postvoid residual volume (PVR)
Intra articular methylprednisolone acetate injection efficacy in the treatment of primary knee osteoarthritis at Hue Central Hospital and Hospital of Hue University of Medicine and Pharmacy
Authors: Pham Minh Trai , Nguyen Hoang Thanh Van
Published: September 2020

Introduction/Background: Osteoarthritis is still an incurable disease, the current treatment is to reduce clinical symptoms. The intra articular glucocorticoid injection in knee osteoarthritis makes the inflammatory process self-limiting and improves pain symptom.

Objectives: To evaluate the efficacy and safety of intra articular methylprednisolone acetate injection in treatment of primary knee osteoarthritis.

Materials and Methods: Prospective descriptive study of 88 knee joints (34 joints in study group, 54 joints in control group) was diagnosed with primary osteoarthritis according to the American College of Rheumatology (ACR) classification criteria and in Kellgen & Lawrence grade II, III. The patient was assessed about clinical features, subclinical features and the VAS score, Lequesne index at the initial of the study and 7 days later.

Results: The analgesic effect was higher in the group of intra articular methylprednisolon injection with statistically significant difference (∆VAS of the study group and the control group were 38.65 ± 9.25; 25.11 ± 9.26, respectively, with p < 0.05). The improving of knee function was higher in the group of intra articular methylprednisolon injection with statistically significant difference (∆Lequesne of the study group and the control group were 7.00 (5.00 – 8.00); 4.00 (3.00 – 5.00), respectively, with p < 0.05). The incidence of complications in the study group was 1/34 (2.94%) with post – injection pain. The improvement of VAS is better in patient with severe pain than those with moderate pain (p < 0.05) and correlated to the initial value of Lequesne (r2 = 0,162, respectively, with p < 0.05). The improvement of Lequesne correlated to the joint fluid thickness in ultrasound (r2 = 0.102, p < 0.05). There is no relation between efficacy of treatment and site of knee joint, radiology stage and synovial membrane thickness (p > 0.05).

Conclusions: The intra articular methylprednisolone acetate injection in treatment of primary knee osteoarthritis is a safe treatment and has significant, clearly effect in pain relief and physical function improving after 7 days. The improvement of VAS is better in the patient with higher initial value of VAS, Lequesne and the improvement of Lequesne is better in the patients with more synovial thickness in ultrasound.

Key words: Knee osteoarthritis, intraarticular injection, methylprednisolon acetate
Obezite Prevelansının En Yüksek ve En Düşük Olduğu İllerde Öğrenim Gören Öğrencilerin Obez Gebelere İlişkin Ön Yargılarının Belirlenmesi
Authors: GÜR Elif Yağmur , EJDER APAY Serap , ÖZTÜRK ALTINAYAK Serap , NAZİK Evşen
Published: September 2020

Amaç: Bu çalışma ülkemizde obezite oranının il bazında en çok ve en az olan yerlerde eğitim gören ebelik öğrencilerinin obez gebelere ilişkin ön yargılarını belirlemek amacıyla yapılmıştır.
Yöntem: Tanımlayıcı ve karşılaştırmalı tasarımda olan bu araştırma Mart-Haziran 2017 tarihleri arasında Adana-nüfusu en şişman (n:141) ve Erzurum- nüfusu en zayıf (n:161) illerinde bulunan sağlık bilimleri fakültelerinin 2., 3. ve 4. sınıfta eğitim gören 302 ebelik bölümü öğrencisi ile yürütülmüştür. Veriler “Kişisel Bilgi Formu”, ve “GAMS-27 Obezite Önyargı Ölçeği” kullanılarak toplanmıştır. Verilerin değerlendirilmesinde sayı, yüzdelik dağılım, ortalama, ANOVA, ki kare, Kruskal Wallis ve bağımsız gruplarda t testi kullanılmıştır.
Bulgular: Araştırmada Erzurum ilindeki öğrencilerin GAMS-27 Obezite Önyargı Ölçek toplam puan ortalaması 73.01±7.87 olup, öğrencilerin %72.7’si ön yargıya eğilimli bulunurken; Adana ilindeki öğrencilerin ise ölçek toplam puan ortalaması 79.20±9.98 ve öğrencilerin %51.8’i ön yargıya eğilimli olarak bulunmuştur. Öğrencilerin Tanıtıcı Özelliklerine Göre GAMS-27 Ölçek Puan Ortalamasının Karşılaştırılması değerlendirildiğinde ise Erzurum ili için yaş, sınıf, beslenme şekli, Adana ili için sadece stajlarda fazla kilolu/obez gebelerle karşılaşma durumu arasında istatiksel olarak anlamlı fark belirlenmiştir.
Sonuç: Araştırmada her iki ildeki öğrencilerin ölçek toplam puanları birbirine yakın bulunmuştur. Fakat nüfusu şişman olan ildeki öğrencilerin daha fazla ön yargılı olduğu görülmüştür. Erzurum’daki öğrencilerin ön yargılarını yaş, sınıf ve beslenme şekli etkilerken; Adana’daki öğrencilerin ön yargılarını sadece stajlarda fazla kilolu/obez gebelerle karşılaşmaları etkilemiştir.
Targeting Itch/p73 pathway by thymoquinone as a novel therapeutic strategy for cancers with p53 mutation
Authors: Alghamdi Rashad M , Hassan Mohammed A. , Kaleem Mohammed , Kayali Asaad , Halwani Majed A , Zamzami Mazin A , Choudhry Hani , Alhosin Mahmoud
Published: September 2020

The tumor suppressor p73 is a member of p53 family and has a high degree of similarity with p53 function and structure. Like p53, p73 can also induce the expression of several genes involved in cell cycle and apoptosis. p73 expression is downregulated in many tumors by several mechanisms including the ubiquitination pathway. Thus, understanding the ubiquitin-proteasome pathway in p73 regulation will help in targeting this later and develop a new promising therapeutic strategy for cancer with p53 mutations. The aim of this study was to evaluate the effect of Thymoquinone (TQ), the major biologically active compound of the black seed oil on the expression of several E3 ubiquitin ligase enzymes known to be regulators of p73 and the related events in cancer cells with p53 mutation, such as the human acute lymphoblastic leukemia Jurkat cells, the human triple-negative breast cancer (MDA-MB-468 cells) and human promyelocytic leukemia HL60 cells. RNA-seq data showed that several E3 ubiquitin-ligase enzymes, well documented to be involved in the degradation of p73 including Itch, Pirh2, E3s Pin2, Mdm2, TRIM32 and SCFFBXO45 were downregulated in Jurkat cells. Among the target genes, Itch was significantly downregulated in TQ-treated Jurkat cells as compared with control cells. TQ-induced Itch downregulation was confirmed by real-time RT-PCR in Jurkat cells, MDA-MB-468 cells and HL60. Treating Jurkat cells with either TQ or the proteasome inhibitor MG132 induced an upregulation of p73. The present study indicates that TQ could be a promising inhibitor of the E3-ubiquitin ligase Itch leading to the upregulation of tumor suppressor p73 in cancers expressing mutant p53.
Nutrient Profiling of Tropical Soybean (Glycine Max) Core Collection
Authors: Obua Tonny , Sserumaga Julius P. , Nganga Fredrick , Tukamuhabwa Phineas , Odong Thomas L. , Mutuku Josiah , Yao Nasser
Published: September 2020

Soybean (Glycine max (L.) Merrill) is a highly nutritious legume with enormous potential to improve dietary quality for humans and livestock. However, the development of varieties with improved nutritional traits has been affected by the negative correlation that exists among the different traits and the high cost of the phenotypic assessment. The objectives of this study were: (1) to quantify the total protein, total oil and fatty acids of 52 soybean genotypes from different sources, (2) to identify correlations among total protein, total oil content and fatty acids. The total protein content was determined using the Modified Folin-Lowry Method. In contrast, the total oil and fatty acids methyl esters were determined using the chloroform/methanol gravimetric method and Gas Chromatography–Mass Spectrometry. The analysis of variance revealed that the studied traits varied significantly depending on genotypes and origin.
Türkiye’deki Fırat Nehri Drenajından Oxynoemachelius (Teleostei: Nemacheilidae) Türlerinin COI-barkod Bölgesine Dayalı Genetik Tanımlaması ve Filogenetik İlişkileri
Authors: RAKICI Hande , AKSU İsmail , BEKTAŞ Yusuf
Published: September 2020

Bu çalışmada, DNA barkodlama tekniği ile Türkiye’nin Fırat nehir havzasındaki Oxynoemacheilus türlerini güvenilir bir şekilde tanımlama yeteneği araştırılmıştır. Oxynoemacheilus genusunu temsilen 6 türe ait 167 bireyi barkodlamak için mitokondri sitokrom c oksidaz altünite I' in (COI) barkod bölgesi (627 bp) kullanıldı. Kimura 2 parametresine dayalı olarak (K2P), maksimum tür içi ve minimum türlerarası genetik mesafeleri sırasıyla % 0.59 ve % 1.62‘dır. En yakın komşu türler arası mesafeler, ortalama tür içi mesafeden 7 kat daha yüksektir ve belirgin bir DNA barkod aralığı fark edilmiştir. Filogeni tabanlı DNA barkodlama başarısı testine göre komşu-birleştirme fenogramları K2P modeli kullanılarak 1000 seç-bağla replikasyonu ile üretildi ve örneklerin tümünün türlerin taksonomik durumları ile uyumlu olarak kümelendiği belirlenmiştir. MP ve ML filogenileri, Doğu ve Batı Anadolu gruplarına karşılık gelen iki klad içeren bir ortak ağaç topolojisi gösterdi. Bu çalışmanın sonuçları, COI geninin yaklaşık % 81 başarı oranıyla Oxynoemacheilus türlerinin belirlenmesi ve sınırlandırılması için uygun bir DNA barkod belirleyicisi olabileceğini göstermektedir.
“Católicos” y “Tecnócratas”. Diagnósticos, políticas y discusiones en torno a la previsión social durante la última dictadura
Authors: Osuna María Florencia
Published: September 2020

En este trabajo se analizan las principales políticas relacionadas con el sistema de previsión social que se desarrollaron durante la última dictadura militar argentina (1976-1983). En relación con esto, se estudian las distintas discusiones y los proyectos divergentes de los funcionarios nucleados en torno al Ministerio de Bienestar Social y al Ministerio de Economía.
Relatos identitarios e Historia Local. Desafíos para la Historiografía y la enseñanza de la Historia
Authors: Canedo Mariana
Published: September 2020

El  trabajo  analiza  aspectos  de  la  historia  local  clásica  como relato  identitario que  la  vincula  con  las  historias  nacionales. Los  cambios  en  los  enfoques historiográficos  modifican  esta situación  en  relación  con  la  producción  de  conocimiento. Sin embargo, la persistencia de las finalidades vinculadas con la identidad en el sistema educativo pareciera complejizar el escenario y generan desafíos.
Una historia peligrosa: la Historia Reciente bajo sospecha
Authors: Altamirano Héctor
Published: September 2020

Desde el principio hay que aclarar que el trabajo no pretende cerrar un tema, sino simplemente presentar algunas dudas, algunas interrogantes a un objeto de estudio (la historia reciente) que desde la asunción al gobierno del Frente Amplio en marzo de2005 hacobrado nuevo impulso a nivel de la sociedad y por tanto a nivel de la academia.Previamente a  trabajar sobre el tema de la historia reciente, se hará una recorrida por algunas concepciones que nos aproximarán a lo qué es la ciencia; qué se entiende por ella; y a la relación que existe entre la ciencia y la sociedad; entre la ciencia y la política. Al decir de Bourdieu se reflexionará sobre lo simbólico y las luchas entre las diferentes fuerzas que pugnan por imponer su mirada.  Luego se pasará a trabajar el tema de la historia reciente en el Uruguay. Allí el trabajo tendrá algunas preguntas guías. Estas preguntas serán las siguientes: ¿el conocimiento del pasado reciente está limitado por problemas o cuestiones sociales (económicos, políticos, miedos, etc.)?; ¿el discurso sobre la historia reciente de algunos sectores políticos está más presente en la sociedad que los discursos producidos por los cientistas sociales?; ¿qué papel juegan estos científicos en torno a la vida presente del país y a la memoria colectiva de nuestra sociedad?A través de estas preguntas se intentará reflexionar, desnaturalizar y problematizar la producción historiográfica sobre el pasado reciente de nuestro país y en cómo se vinculan estos temas con el presente.
Redes de poder durante el “Estado Novo” brasileño: los intelectuales autoritarios y la constelación Capanema
Authors: De Lima Grecco Gabriela
Published: September 2020

Este artículo tiene por objetivo analizar las redes que existieron entre algunas figuras del sector intelectual brasileño y su rol al interior del Estado Novo (1937-1945). Para ello, se examinan las relaciones personales, profesionales e ideológicas entre este grupo de escritores, así como sus vínculos con los órganos estatales, y con el espacio público que ocuparon
Tiempos antiperonistas en la Patagonia argentina. La acción de las Comisiones Investigadoras durante la “Revolución Libertadora”
Authors: Ruffini Martha
Published: September 2020

En 1955 se produjo un nuevo quiebre institucional en Argentina, que provocó el final del llamado “peronismo histórico” (1946-1955). A partir de entonces, la autodenominada Revolución Libertadora (1955-1958) quedó asociada indisolublemente a la exclusión política mediante la proscripción electoral del partido justicialista, sus ex funcionarios y el líder mismo. En la Patagonia la Dictadura Militar puso entre paréntesis la creación de nuevas provincias dispuesta por el peronismo. Al igual que en el resto de las provincias, el gobierno de facto ordenó la adopción de medidas tendientes a perseguir, investigar y juzgar las actividades del partido peronista y de sus principales funcionarios en el marco del proceso de desperonización impulsado desde el gobierno de facto. En ese sentido la acción de las comisiones y sub comisiones Investigadoras provinciales se materializó en una multiplicidad de denuncias, detenciones y cesantías que demuestran la trama del poder anudada en los ex territorios nacionales del sur, con una sociedad movilizada que colaboró activamente con la intervención federal como parte del aval al pacto proscriptivo, evidenciando la escasa valencia del concepto democracia como rasgo dominante.
La represión antiperonista y su justificación en Jujuy en tiempos de la Revolución Libertadora
Authors: Castillo Fernando Aníbal
Published: September 2020

La destitución del gobierno peronista, ejecutada en septiembre de 1955 mediante un golpe de Estado, conllevó la institución de una administración antiperonista, denominada “Revolución Libertadora”, cuya lógica apuntaba a la proscripción absoluta del peronismo. Este régimen ejerció la represión contra el peronismo mediante diversos procedimientos. Estas medidas se pusieron en operación en todo el territorio nacional, y alcanzaron de esta forma a la provincia de Jujuy. En este distrito, la política estatal de coacción al peronismo comportó medidas como la encarcelación de sus militantes y la supresión de sus símbolos del espacio público. Este dispositivo se justificó en términos generales en esta jurisdicción mediante la apelación a los principios del antiperonismo radicalizado, basado en la representación del peronismo como un régimen totalitario.
Imago Mundi: un acercamiento al internacionalismo intelectual
Authors: Fernández Talavera Mariana
Published: September 2020

En las páginas de la revista Imago Mundi (1953-1956) publicada en Buenos Aires, nos encontramos con una gran cantidad de artículos que se refieren a conocimiento que está produciéndose fuera de la Argentina. En este trabajo, vinculamos esta característica a cierto diagnóstico de poca y pobre producción intelectual nacional durante los años del gobierno peronista. En este sentido, analizamos aquí los vínculos o redes que se dan a través de la revista con lo que está produciendo en Europa y cómo esto configura el ideal cultural al que esta revista aspira así como también una representación de la labor intelectual durante esos años.
EFEKTIVITAS PENGGUNAAN MODUL TERHADAP PENINGKATAN NILAI AKHIR SISWA PADA PELAJARAN BAHASA INGGRIS
Authors: Wahayuningrum Tutut
Published: September 2020

Modul sebagai sarana media pembelajaran dapat menjadi salah satu salusi dalam menerapkan model pembelajaran SAINTIFIK yaitu dengan menggunakan prinsip-prinsip pembelajaran berbasis pada siswa (selft concept) yang artinya adalah pembelajaran yang dilakukan dengan orientasi pencapaian kompetensi peserta didik, sehingga tujuan akhir hasil pembelajaran adalah meningkatkan kompetensi peserta didik yang dapat diukur dalam pola sikap, pengetahuan, dan keterampilannya.

Berangkat dari konsep tersebut, studi ini ditujukan untuk mengkaji secara empiris efektifitas modul dalam meningkatkan kemampuan bahasa Inggris siswa yang diukur melalui nilai akhir siswa yang dilakukan dengan menggunakan pendekatan independent sample t test.

Hasil pengujian empiris yang dilakukan pada studi ini menunjukkan bahwa pemberian modul kepada siswa terbukti efektif untuk meningkatkan kemampuan bahasa Inggris siswa yang ditunjukkan dari perolehan nilai akhir siswa.

 

Kata Kunci:   modul, efektifitas