bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation between Temporomandibular Disorders and Tinnitus and Possible Treatment Strategies: Comprehensive Review
Authors: Inchingolo Angelo Michele , Inchingolo Alessio Danilo , Settanni Vito , De Leonardis Nicole , Campanelli Merigrazia , Garofoli Grazia , Benagiano Stefania , Malcangi Giuseppina , Minetti Elio , Palermo Andrea , Inchingolo Francesco , Dipalma Gianna , Patano Assunta
Published: August 2023

This study intends to investigate the relationship between otologic symptoms, in particular, tinnitus, and temporomandibular disorders (TMD). The literature studies during the previous 20 years had focused on the treatment and alleviation of the otologic symptoms and were limited to randomized clinical trials, case reports, and prospective studies. The following Boolean keywords, (tinnitus) AND (temporomandibular disorders OR temporomandibular therapy), were used in the databases of PubMed, Scopus, and Web of Science between 2003 and 9 May 2023 with an English language restriction. Results: The computerized search turned up 693 articles in total, and after eliminating duplicates, reviewing them, and determining their eligibility, 20 papers were included. Conclusion: The connections between temporomandibular TMD and tinnitus are numerous and intricate. It is unclear whether TMD could be the source of tinnitus or only its symptoms. Tinnitus may not always occur in persons with TMD, indicating that additional causes may potentially be involved in its occurrence. The precise mechanisms behind the link between TMD and tinnitus need to be clarified by additional study.
Extending Multi-Pathway Human Health Risk Assessment from Regional to Country-Wide—A Case Study on Kuwait
Authors: Munshed Mohammad , Van Griensven Thé Jesse , Fraser Roydon , Matthews Bryan , Ramadan Ashraf
Published: August 2023

Air pollution has emerged as a pressing global issue in recent decades. While criteria pollutants and greenhouse gases contribute to the problem, this article explicitly addresses hazardous air pollutants (HAPs). This work estimates the country-wide cumulative human health impacts from exposure to HAPs. Kuwait is used as the case study due to data availability and non-fragmentation of data. At present, the evaluation of multi-pathway human health risks arising from exposure to HAPs is incomplete, as indirect pathways have not been considered. Furthermore, only a few HAPs, such as benzene, have established ambient air quality standards specifically intended to safeguard human health, leaving many HAPs unregulated. This study considers several pathways (both direct and indirect) and various environmental media (air, water, plants, soil, and animal tissue). The findings indicate that cumulative health risks in the coastal air quality zone are within acceptable limits but are notably higher when compared to the other air quality zones. For cancer risks, only the Ahmadi Hospital, with a cancer risk of 1.09 × 10−5 for the resident adult exposure scenario, slightly exceeds the acceptable risk level of 1 × 10−5. The proposed methodology integrates the results from a country-wide emissions inventory composed of different air quality zones, air dispersion and deposition modeling, multi-pathway transport-and-fate analysis, exposure quantification, and health risk and hazard characterization. It also extends and adapts EPA methodologies initially designed for hazardous waste combustion facilities to additional emission sources and provides a case study for a region seldom subjected to such human health risk assessments.
Comparative Analysis of Neural Network Models for Predicting Ammonia Concentrations in a Mechanically Ventilated Sow Gestation Facility in Korea
Authors: Park Junsu , Jo Gwanggon , Jung Minwoong , Oh Youngmin
Published: August 2023

Conventional methods for monitoring ammonia (NH3) emissions from livestock farms have several challenges, such as a poor environment for measurement, difficulty in accessing livestock, and problems with long-term measurement. To address these issues, we applied various neural network models for the long-term prediction of NH3 concentrations from sow farms in this study. Environmental parameters, including temperature, humidity, ventilation rate, and past records of NH3 concentrations, were given as inputs to the models. These neural network models took the encoder or the feature extracting parts from the representative deep learning models, including Long Short-Term Memory (LSTM), Convolutional Neural Network (CNN), and Transformer, to encode temporal patterns of time series. However, all of these models adopted dense layers for the decoder to format the task of long-term prediction as a regression problem. Due to their regression nature, all models showed a robust performance in predicting long-term NH3 concentrations at a scale of weeks or even months despite there being a relatively short period of input signals (a few days to a week). Given one week of input, LSTM showed the minimum mean absolute errors (MAE) of 1.83, 1.78, and 1.87 ppm for the prediction of one, two, and three weeks, respectively, whereas Transformer performed best with a MAE of 1.73 ppm for a four-week prediction. In the long-term estimation of spanning months, LSTM showed the minimum MAEs of 1.95 and 1.90 ppm when trained on predicting two and three weeks of windows. At the same condition, Transformer gave the minimum MAEs of 1.87 and 1.83 when trained on predicting one and four weeks of windows. Overall, the neural network models can facilitate the prediction of national-level NH3 emissions, the development of mitigation strategies for NH3-derived air pollutants, odor management, and the monitoring of animal-rearing environments. Further, their integration of real-time measurement devices can significantly prolong device longevity and offer substantial cost savings.
Convection-Permitting Regional Climate Simulation over Bulgaria: Assessment of Precipitation Statistics
Authors: Valcheva Rilka , Popov Ivan , Gerganov Nikola
Published: August 2023

With increasing computational power, the regional climate modeling community is moving to higher resolutions of a few kilometers, named convection-permitting (CP) simulations. This study aims to present an assessment of precipitation metrics simulated with the non-hydrostatic regional climate model RegCM-4.7.1 at CP scale for a decade-long period (2001–2010) for Bulgaria. The regional climate simulation at 15 km grid spacing uses ERA-Interim (0.75° × 0.75°) re-analysis as the driving data and parametrized deep convection. The kilometer-scale simulation at 3 km horizontal grid spacing is nested into regional climate simulation using parametrized shallow convection only. The CP simulation is evaluated against daily and hourly datasets available for the selected period and is compared with the coarser resolution driving simulation. The results show that the model represents well the spatial distribution of mean precipitation at the regional and kilometer scale for the territory of Bulgaria. However, the CP_RegCM_3km model produces too much precipitation over the mountains and shows the largest biases in the summer season (above 100%). At the daily scale, improvements are found in CP simulation for precipitation wet-day intensity and extreme precipitation in the autumn and for wet-day frequency in the summer. At the hourly scale, the kilometer-scale simulation improved the performance of wet-hour precipitation intensity in all seasons compared with coarse-resolution simulation (−23% vs. −46% in MAM; −10% vs. −37% in JJA; −47% vs. −53% in SON; −54% vs. −62% in DJF) and extreme precipitation in the autumn (−7% vs. −51%) and winter (−34% vs. −58%). The representation of wet-hour frequency was improved by CP_RegCM_3km in all seasons, except summer (−3.1% vs. −6.7% in spring; 0.5% vs. −3.8% in autumn and −7.7% vs. −11.5% in winter).
MAGDM Model Using an Intuitionistic Fuzzy Matrix Energy Method and Its Application in the Selection Issue of Hospital Locations
Authors: Li Weiming , Ye Jun
Published: August 2023

Matrix energy is a valid mathematical tool for representing collective information. However, it is not used in the existing literature for fuzzy sets, intuitionistic fuzzy sets, and multi-attribute group decision making (MAGDM) problems, which highlights research gaps. Motivated by both matrix energy and the research gaps, this study aims to extend matrix energy to the energy of an intuitionistic fuzzy matrix (IFM) and to utilize the IFM energy method in the MAGDM problem, which fully contains all the IFM information on attribute weights, decision maker weights, and attribute values. To achieve these objectives, this paper first proposes IFM energy in terms of the true matrix energy and false matrix energy; then, it develops a MAGDM model using the IFM energy method and the score and accuracy equations of IFM energy. Then, the developed MAGDM model is applied to the selection problem of hospital locations in Shaoxing City, China to demonstrate the practicality and validity of the developed model. Compared with existing intuitionistic fuzzy MAGDM methods, the developed MAGDM model using the IFM energy method reveals its superiority and novelty in complete IFM information expressions and the MAGDM method because the existing MAGDM methods containing intuitionistic fuzzy set information have difficulty tackling MAGDM problems containing all the IFM information on attribute weights, decision maker weights, and attribute values.
Comparison of Cost and Potency of Human Mesenchymal Stromal Cell Conditioned Medium Derived from 2- and 3-Dimensional Cultures
Authors: Madrigal Marialaura , Fernández Patricia L. , Lleonart Ricardo , Carreño Lizmar , Villalobos Gorday Kaiser Alejandro , Rodríguez Ellís , de Cupeiro Kathya , Restrepo Carlos M. , Rao K. S. Jagannatha , Riordan Neil H.
Published: August 2023

Mesenchymal stromal cell (MSC)-derived products, such as trophic factors (MTFs), have anti-inflammatory properties that make them attractive for cell-free treatment. Three-dimensional (3D) culture can enhance these properties, and large-scale expansion using a bioreactor can reduce manufacturing costs. Three lots of MTFs were obtained from umbilical cord MSCs produced by either monolayer culture (Monol MTF) or using a 3D microcarrier in a spinner flask dynamic system (Bioreactor MTF). The resulting MTFs were tested and compared using anti-inflammatory potency assays in two different systems: (1) a phytohemagglutinin-activated peripheral blood mononuclear cell (PBMNC) system and (2) a lipopolysaccharide (LPS)-activated macrophage system. Cytokine expression by macrophages was measured via RT-PCR. The production costs of hypothetical units of anti-inflammatory effects were calculated using the percentage of TNF-α inhibition by MTF exposure. Bioreactor MTFs had a higher inhibitory effect on TNF (p < 0.01) than monolayer MTFs (p < 0.05). The anti-inflammatory effect of Bioreactor MTFs on IL-1β, TNF-α, IL-8, IL-6, and MIP-1 was significantly higher than that of monolayer MTFs. The production cost of 1% inhibition of TNF-α was 11–40% higher using monolayer culture compared to bioreactor-derived MTFs. A 3D dynamic culture was, therefore, able to produce high-quality MTFs, with robust anti-inflammatory properties, more efficiently than monolayer static systems.
Empirical Quantification of Optic Nerve Strain Due to Horizontal Duction
Authors: Lim Seongjin , Demer Joseph L.
Published: August 2023

Magnetic resonance imaging (MRI) was used to measure in vivo local strains in the optic nerve (ON) associated with horizontal duction in humans. Axial and coronal MRI were collected in target-controlled gazes in 24 eyes of 12 normal adults (six males and six females, 59 ± 16 years) during large (~28°) and moderate (~24°) ductions. The ON, globe, and extraocular muscles were manually identified, and the pixels were converted to point-sets that were registered across different imaging planes and eye positions. Shape of the ON was parameterized based on point-sets. Displacements and strains were computed by comparing deformed with initial ON configurations. Displacements were the largest in the most anterior region. However, strains from adduction were uniform along the length of the ON, while those during abduction increased with distance from the globe and were maximal near the orbital apex. For large gaze angles, ON strain during abduction was primarily due to bending near the orbital apex that is less transmitted to the eye, but during adduction the ON undergoes uniform stretching that transmits much greater loading to the posterior eye, implied by greater strain on the ON.
Development of a Machine Learning Model of Postoperative Acute Kidney Injury Using Non-Invasive Time-Sensitive Intraoperative Predictors
Authors: Zamirpour Siavash , Hubbard Alan E. , Feng Jean , Butte Atul J. , Pirracchio Romain , Bishara Andrew
Published: August 2023

Acute kidney injury (AKI) is a major postoperative complication that lacks established intraoperative predictors. Our objective was to develop a prediction model using preoperative and high-frequency intraoperative data for postoperative AKI. In this retrospective cohort study, we evaluated 77,428 operative cases at a single academic center between 2016 and 2022. A total of 11,212 cases with serum creatinine (sCr) data were included in the analysis. Then, 8519 cases were randomly assigned to the training set and the remainder to the validation set. Fourteen preoperative and twenty intraoperative variables were evaluated using elastic net followed by hierarchical group least absolute shrinkage and selection operator (LASSO) regression. The training set was 56% male and had a median [IQR] age of 62 (51–72) and a 6% AKI rate. Retained model variables were preoperative sCr values, the number of minutes meeting cutoffs for urine output, heart rate, perfusion index intraoperatively, and the total estimated blood loss. The area under the receiver operator characteristic curve was 0.81 (95% CI, 0.77–0.85). At a score threshold of 0.767, specificity was 77% and sensitivity was 74%. A web application that calculates the model score is available online. Our findings demonstrate the utility of intraoperative time series data for prediction problems, including a new potential use of the perfusion index. Further research is needed to evaluate the model in clinical settings.
Towards an Understanding of Microglia and Border-Associated Macrophages
Authors: Taketomi Takumi , Tsuruta Fuminori
Published: August 2023

The central nervous system (CNS) plays a crucial role in regulating bodily functions by sensing and integrating environmental cues and maintaining proper physiological conditions. Recent research has revealed that CNS functions are closely coordinated with the immune system. As even minor disturbances of the immune system in the CNS can lead to various dysfunctions, diseases, or even death, it is highly specialized and segregated from that in peripheral regions. Microglia in the parenchyma and macrophages at the interface between the CNS and peripheral regions are essential immune cells in the CNS that monitor environmental changes. Recent omics analyses have revealed that these cells exhibit highly heterogeneous populations. In this review, we summarize the functions and diversity of microglia in the brain parenchyma and those of macrophages in the border regions, such as the meninges, perivascular spaces, and choroid plexus.
Hydrogen Sulfide Prevents LPS-Induced Depression-like Behavior through the Suppression of NLRP3 Inflammasome and Pyroptosis and the Improvement of Mitochondrial Function in the Hippocampus of Mice
Authors: Bao Peng , Gong Yuxiang , Wang Yanjie , Xu Miaomiao , Qian Zhenyu , Ni Xin , Lu Jianqiang
Published: August 2023

Hydrogen sulfide (H2S) has been implicated to have antidepressive effects. We sought to investigate the prevention effects of H2S donor NaHS on depression-like behavior induced by lipopolysaccharide (LPS) in mice and its potential mechanisms. Sucrose preference, force swimming, open field, and elevate zero maze were used to evaluate depression-like behavior. NF-κB and NLRP3 inflammasome activation and mitochondrial function in the hippocampus were determined. It was found that depression-like behavior induced by LPS was prevented by NaHS pretreatment. LPS caused NF-κB and NLRP3 inflammasome activation in the hippocampus as evidenced by increased phosphorylated-p65 levels and increased NLRP3, ASC, caspase-1, and mature IL-1β levels in the hippocampus, which were also blocked by NaHS. LPS increased GSDMD-N levels and TUNEL-positive cells in the hippocampus, which was prevented by NaHS. Abnormal mitochondrial morphology in the hippocampus was found in LPS-treated mice. Mitochondrial membrane potential and ATP production were reduced, and ROS production was increased in the hippocampus of LPS-treated mice. NaHS pretreatment improved impaired mitochondrial morphology and increased membrane potential and ATP production and reduced ROS production in the hippocampus of LPS-treated mice. Our data indicate that H2S prevents LPS-induced depression-like behaviors by inhibiting NLRP3 inflammasome activation and pyroptosis and improving mitochondrial function in the hippocampus.
In Silico Virome Analysis of Chinese Narcissus Transcriptomes Reveals Diverse Virus Species and Genetic Diversity at Different Flower Development Stages
Authors: Choi Hoseong , Jo Yeonhwa , Cho Won Kyong
Published: August 2023

Viromes of Chinese narcissus flowers were explored using transcriptome data from 20 samples collected at different flower development stages. Quality controlled raw data underwent de novo assembly, resulting in 5893 viral contigs that matched the seven virus species. The most abundant viruses were narcissus common latent virus (NCLV), narcissus yellow stripe virus (NYSV), and narcissus mottling-associated virus (NMaV). As flower development stages advanced, white tepal plants showed an increase in the proportion of viral reads, while the variation in viral proportion among yellow tepal plants was relatively small. Narcissus degeneration virus (NDV) dominated the white tepal samples, whereas NDV and NYSV prevailed in the yellow tepal samples. Potyviruses, particularly NDV, are the primary infectious viruses. De novo assembly generated viral contigs for five viruses, yielding complete genomes for NCLV, NDV, narcissus late season yellow virus (NLSYV), and NYSV. Phylogenetic analysis revealed genetic diversity, with distinct NCLV, NMaV, NDV, NLSYV, and NYSV groups. This study provides valuable insights into the viromes and genetic diversity of viruses in Chinese narcissus flowers.
The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia
Authors: Vellucci Licia , Ciccarelli Mariateresa , Buonaguro Elisabetta Filomena , Fornaro Michele , D’Urso Giordano , De Simone Giuseppe , Iasevoli Felice , Barone Annarita , de Bartolomeis Andrea
Published: August 2023

Almost 25% of schizophrenia patients suffer from obsessive-compulsive symptoms (OCS) considered a transdiagnostic clinical continuum. The presence of symptoms pertaining to both schizophrenia and obsessive-compulsive disorder (OCD) may complicate pharmacological treatment and could contribute to lack or poor response to the therapy. Despite the clinical relevance, no reviews have been recently published on the possible neurobiological underpinnings of this comorbidity, which is still unclear. An integrative view exploring this topic should take into account the following aspects: (i) the implication for glutamate, dopamine, and serotonin neurotransmission as demonstrated by genetic findings; (ii) the growing neuroimaging evidence of the common brain regions and dysfunctional circuits involved in both diseases; (iii) the pharmacological modulation of dopaminergic, serotoninergic, and glutamatergic systems as current therapeutic strategies in schizophrenia OCS; (iv) the recent discovery of midbrain dopamine neurons and dopamine D1- and D2-like receptors as orchestrating hubs in repetitive and psychotic behaviors; (v) the contribution of N-methyl-D-aspartate receptor subunits to both psychosis and OCD neurobiology. Finally, we discuss the potential role of the postsynaptic density as a structural and functional hub for multiple molecular signaling both in schizophrenia and OCD pathophysiology.
Oxidative Stress as a Regulatory Checkpoint in the Production of Antiphospholipid Autoantibodies: The Protective Role of NRF2 Pathway
Authors: Sorice Maurizio , Profumo Elisabetta , Capozzi Antonella , Recalchi Serena , Riitano Gloria , Di Veroli Benedetta , Saso Luciano , Buttari Brigitta
Published: August 2023

Oxidative stress is a well-known hallmark of Antiphospholipid Antibody Syndrome (APS), a systemic autoimmune disease characterized by arterial and venous thrombosis and/or pregnancy morbidity. Oxidative stress may affect various signaling pathways and biological processes, promoting dysfunctional immune responses and inflammation, inducing apoptosis, deregulating autophagy and impairing mitochondrial function. The chronic oxidative stress and the dysregulation of the immune system leads to the loss of tolerance, which drives autoantibody production and inflammation with the development of endothelial dysfunction. In particular, anti-phospholipid antibodies (aPL), which target phospholipids and/or phospholipid binding proteins, mainly β-glycoprotein I (β-GPI), play a functional role in the cell signal transduction pathway(s), thus contributing to oxidative stress and thrombotic events. An oxidation–antioxidant imbalance may be detected in the blood of patients with APS as a reflection of disease progression. This review focuses on functional evidence highlighting the role of oxidative stress in the initiation and progression of APS. The protective role of food supplements and Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) activators in APS patients will be summarized to point out the potential of these therapeutic approaches to reduce APS-related clinical complications.
Relationship of Fibroblast Growth Factor 23 Serum Levels with Disease Characteristics in Systemic Lupus Erythematosus Patients
Authors: Fernández-Cladera Yolanda , Gómez-Bernal Fuensanta , García-González María , Quevedo-Abeledo Juan C. , González-Rivero Agustín F. , de Vera-González Antonia , Martín-González Candelaria , Nunes-Andrade Ana L. , López-Mejías Raquel , González-Gay Miguel Á. , Ferraz-Amaro Iván
Published: August 2023

Fibroblast growth factor 23 (FGF23), a hormone secreted by osteocytes and osteoblasts, is a major regulator of vitamin D and phosphate homeostasis. FGF23 has been associated with the disturbance of mineral homeostasis, and with kidney and cardiovascular diseases. Systemic lupus erythematosus (SLE) is an autoimmune disorder that can affect virtually any organ. In the present work, we set out to analyze the relationship of FGF23 with the expression of SLE, including patterns of activity, damage, and severity. A total of 284 well-characterized patients with SLE were recruited. Activity (SLEDAI), severity (Katz), and damage index (SLICC-DI) scores were determined. The serum levels of FGF23 were also assessed. Multivariable linear regression analysis was performed to study the relationship between disease characteristics and FGF23. FGF23 and 25(OH) vitamin D were negatively correlated. Furthermore, prednisone use was associated with higher circulating FGF23 after an adjustment for confounding factors. SLICC-DI was related to higher serum levels of FGF23 after a multivariable analysis. However, when the SLICC-DI index items and domains were analyzed separately, apart from proteinuria ≥3.5 gm/24 h, only the musculoskeletal domain, encompassing arthritis and osteoporosis, was significantly associated with higher serum levels of FGF23. In conclusion, an association is observed between elevated serum FGF23 levels and disease damage, particularly related to musculoskeletal complications and proteinuria, in patients with SLE.
Assessing the Impact of COVID-19 Vaccines on Sickle Cell Anaemia Patients: A Comparative Analysis of Biochemical and Haematological Parameters
Authors: Aldali Jehad A. , Alotaibi Badi A. , Aldali Hamzah J. , Alasiri Glowi A. , Alaseem Ali , Almuqrin Abdulaziz M. , Alshalani Abdulrahman , Alotaibi Fahad T.
Published: August 2023

The coronavirus disease 2019 (COVID-19) vaccines have been developed to help prevent the spread of the virus infections. The COVID-19 vaccines, including Pfizer, Moderna, and AstraZeneca, have undergone rigorous testing and have demonstrated both safety and effectiveness. Extensive evidence supports their effectiveness in preventing severe illness, hospitalization, and mortality associated with COVID-19 infection. The administration of COVID-19 vaccines can directly affect hematological and biochemical parameters, with reported cases showing an association with thrombosis and thrombocytopenia. Therefore, it was hypothesized that COVID-19 vaccines may also influence hematological and biochemical markers in sickle cell patients. This study aimed to investigate the side effects of COVID-19 vaccines on sickle cell patients, providing a comprehensive evaluation of hematological and biochemical parameters. To our knowledge, this is the first study of its kind conducted in Saudi Arabia. The study included the evaluation of Pfizer and Oxford-AstraZeneca vaccines in sickle cell patients, measuring key parameters. Our findings revealed varying impacts of both vaccines on the ALT, AST, and CRP levels. Notably, CRP and ALT exhibited potential as indicators for renal disease, diabetes, and arthritis. However, further investigations are necessary to uncover the underlying mechanisms that drive these observed differences and comprehend their clinical implications for this vulnerable patient population. The unique nature of our study fills a crucial research gap and underscores the need for additional research in this area.
Parametric Design and Prototyping of a Low-Power Planar Biped Robot
Authors: Şafak Koray K. , Baturalp Turgut Batuhan , Bozkurt Selim
Published: August 2023

This study proposes a design approach and the development of a low-power planar biped robot named YU-Bibot. The kinematic structure of the robot consists of six independently driven axes, and it weighs approximately 20 kg. Based on biomimetics, the robot dimensions were selected as the average anthropomorphic dimensions of the human lower extremities. The optimization of the mechanical design and actuator selection of the robot was based on the results of parametric simulations. The natural human walking gait was mimicked as a walking pattern in these simulations. As a result of the optimization, a low power-to-weight ratio of 30 W/kg was obtained. The drive system of the robot joints consists of servo-controlled brushless DC motors with reduction gears and additional bevel gears at the knee and ankle joints. The robot features spring-supported knee and ankle joints that counteract the robot’s weight and compensate for the backlash present in these joints. The robot is constrained to move only in the sagittal plane by using a lateral support structure. The robot’s feet are equipped with low-cost, force-sensitive resistor (FSR)-type sensors for monitoring ground contact and zero-moment point (ZMP) criterion. The experimental results indicate that the proposed robot mechanism can follow the posture commands accurately and demonstrate locomotion at moderate stability. The proposed parametric natural gait simulation-based design approach and the resulting biped robot design with a low power/weight ratio are the main contributions of this study.
The Role of Talking Faces in Infant Language Learning: Mind the Gap between Screen-Based Settings and Real-Life Communicative Interactions
Authors: Birulés Joan , Goupil Louise , Josse Jérémie , Fort Mathilde
Published: August 2023

Over the last few decades, developmental (psycho) linguists have demonstrated that perceiving talking faces audio-visually is important for early language acquisition. Using mostly well-controlled and screen-based laboratory approaches, this line of research has shown that paying attention to talking faces is likely to be one of the powerful strategies infants use to learn their native(s) language(s). In this review, we combine evidence from these screen-based studies with another line of research that has studied how infants learn novel words and deploy their visual attention during naturalistic play. In our view, this is an important step toward developing an integrated account of how infants effectively extract audiovisual information from talkers’ faces during early language learning. We identify three factors that have been understudied so far, despite the fact that they are likely to have an important impact on how infants deploy their attention (or not) toward talking faces during social interactions: social contingency, speaker characteristics, and task- dependencies. Last, we propose ideas to address these issues in future research, with the aim of reducing the existing knowledge gap between current experimental studies and the many ways infants can and do effectively rely upon the audiovisual information extracted from talking faces in their real-life language environment.
Antitumoral Activity of Molecular Hydrogen and Proton in the Treatment of Glioblastoma: An Atypical Pharmacology?
Authors: Rochette Luc , Dogon Geoffrey , Zeller Marianne , Cottin Yves , Vergely Catherine
Published: August 2023

Antioxidants in cancer therapy have been a hot topic in the medical field for 20 years. Antioxidants are able to reduce the risk of cancer formation by neutralizing free radicals. Protons (H+) and molecular hydrogen (H2) interact in the cell and are essential in a wide variety of processes. The antioxidant, anti-inflammatory, and antiapoptotic effects of H2 have been studied in numerous experimental and clinical studies. Experimental data indicate that H2 is an antitumor agent in the treatment of glioblastoma (GBM). In vivo H2 inhalation could suppress the growth of GBM tumors, thereby extending the survival of mice with GBM. The sphere-forming ability of glioma cells was suppressed by hydrogen treatment. In addition, H2 treatment also suppressed the migration, invasion, and colony-forming ability of glioma cells. Proton therapy and proton beam radiotherapy offer some advantages over other modern conformal photon-based therapies when used in the treatment of central nervous system malignancies.
Subacute Partially Reversible Leukoencephalopathy Expands the Aicardi–Goutières Syndrome Phenotype
Authors: Peixoto de Barcelos Isabella , Bueno Clarissa , S. Godoy Luís Filipe , Pessoa André , A. Costa Larissa , C. Monti Fernanda , Souza-Cabral Katiane , Listik Clarice , Castro Diego , Della-Ripa Bruno , Freua Fernando , C. Pires Laís , T. Krüger Lia , D. Gherpelli José Luiz , B. Piazzon Flavia , P. Monteiro Fabiola , T. Lucato Leandro , Kok Fernando
Published: August 2023

Objective: To report a series of atypical presentations of Aicardi–Goutières syndrome. Methods: Clinical, neuroimaging, and genetic data. Results: We report a series of six unrelated patients (five males) with a subacute loss of developmental milestones, pyramidal signs, and regression of communication abilities, with onset at ages ranging from 7 to 20 months, reaching a nadir after 4 to 24 weeks. A remarkable improvement of lost abilities occurred in the follow-up, and they remained with residual spasticity and dysarthria but preserved cognitive function. Immunization or febrile illness occurred before disease onset in all patients. CSF was normal in two patients, and in four, borderline or mild lymphocytosis was present. A brain CT scan disclosed a subtle basal ganglia calcification in one of six patients. Brain MRI showed asymmetric signal abnormalities of white matter with centrum semi-ovale involvement in five patients and a diffuse white matter abnormality with contrast enhancement in one. Four patients were diagnosed and treated for acute demyelinating encephalomyelitis (ADEM). Brain imaging was markedly improved with one year or more of follow-up (average of 7 years), but patients remained with residual spasticity and dysarthria without cognitive impairment. Demyelination relapse occurred in a single patient four years after the first event. Whole-exome sequencing (WES) was performed in all patients: four of them disclosed biallelic pathogenic variants in RNASEH2B (three homozygous p.Ala177Thr and one compound heterozygous p.Ala177Thr/p.Gln58*) and in two of them the same homozygous deleterious variants in RNASEH2A (p.Ala249Val). Conclusions: This report expands the phenotype of AGS to include subacute developmental regression with partial clinical and neuroimaging improvement. Those clinical features might be misdiagnosed as ADEM.
A Qualitative Study of the Benefits and Utility of Brief Motivational Interviewing to Reduce Sexually Transmitted Infections among Men Who Have Sex with Men
Authors: Malefo Matshidiso A. , Ayo-Yusuf Olalekan A. , Mokgatle Mathildah Mpata
Published: August 2023

Several studies have demonstrated the effectiveness of motivational interviewing (MI) in reducing sexual risk behaviors. However, limited information is available on the acceptability of brief MI among men who have sex with men (MSM) in poor resource settings like sub-Saharan Africa. The objective of this study was to assess the views of MSM about the benefits and utility of brief MI (bMI) in changing their risky behavior. A qualitative study among men who have sex with men (MSM) who were enrolled in a longitudinal observational study between December 2021 and May 2023. The setting was in Tshwane North and participants were scheduled for baseline, 6-month, and 12-month visits. All participants received 20 min one-on-one face-to-face brief motivational interview (bMI) sessions during their follow-up visits. At month 12, an exit interview was conducted with consenting conveniently sampled participants (n = 23) who had completed all scheduled visits and received three bMI sessions. The findings indicated that the most recalled conversation was related to multiple sexual partners, having sex under the influence of alcohol, and MSM learned more about sexually transmitted diseases. Many expressed being comfortable with the sessions because the counselor was respectful and non-judgmental. Most found the bMI sessions to have a positive impact on changing and reducing risky sexual behaviors, particularly it reportedly increased their use of condoms and reduced the number of multiple partners. MSM found the bMI to be useful and acceptable in reducing sexual risk behaviors among MSM.
Unraveling Abusive Supervision Climate in Aircrew Workplaces: The Roles of Temporary Organizational Features, Trust, and Gender Dynamics
Authors: Qin Zichan , Lee Timothy J.
Published: August 2023

This study aims to advance the theoretical understanding of the contextual antecedents underlying abusive supervision. It provides a fresh perspective on how subordinates’ perceptions of an abusive supervision climate are shaped in temporary work environments. By developing a robust model, this research examines the relationships between temporary organizational characteristics (i.e., temporariness and membership flexibility), trust in ad-hoc supervisors, and perceived abusive supervision climates. We tested the hypothesized model using data from 340 aircrew engaged in temporary and constantly shifting supervisor–subordinate relationships. The results revealed that: (a) temporariness has a direct negative relationship with trust in ad-hoc supervisors, whereas membership flexibility positively affects this trust; (b) the link between temporariness/membership flexibility and a perceived abusive supervision climate is mediated by trust in ad-hoc supervisors. Furthermore, this study highlights gender interactions in a transactional context, indicating that: (c) females perceive a stronger negative association between trust and abusive supervision climates compared to males; and (d) the relationship between temporariness/membership flexibility and trust in ad-hoc supervisors is significant for women and men, respectively. In conclusion, this study underscores the importance of considering the unique organizational characteristics of temporary work settings when examining abusive supervision. It also emphasizes the role of gender in shaping subordinates’ perceptions of a workplace victimization climate, particularly in situations where leader–member exchanges are ephemeral and contractual.
Vocational Interests and Teaching Preferences: Who Prefers Which Teaching Topic in the Nature–Human–Society Subject?
Authors: Pahl Angelika , Tschiesner Reinhard
Published: August 2023

This study focuses on the vocational interests of trainee teachers for kindergarten and primary school, investigating whether the RIASEC-interest dimensions are related to teaching preferences in the Swiss subject of Nature–Human–Society, which is characterized by its multidisciplinarity. Interests are a source of individual differences in people and important to study since they influence intrinsic motivation, and thus, behavior, effort, and occupational decisions. The results of the conducted survey, composed of the Nature–Human–Society questionnaire and the general interest structure test (AIST-R), show, in a sample of 220 participants, that trainee teachers’ vocational interests were partly related to their previous experiences in the specific content domains of Nature–Human–Society and slightly differed by gender. The RIASEC interest dimensions of social, investigative, realistic, and partly artistic evidence significant correlations with preferences in the teaching topics of the Nature–Human–Society subject. It became clear that trainee teachers with high realistic and investigative interests and low social and artistic interests tended to prefer thing-related teaching topics, while pronounced social and artistic interests with low realistic and investigative interests were associated with teaching preferences for people-related topics in the subject of Nature–Human–Society. The dominant role of Prediger’s people- versus thing-related interest orientation could thus also be confirmed in the choice of favorite teaching topics, signaling that teachers feel comfortable with those topics that match their interest structure.
Train-Induced Vibration Prediction and Control of a Metro Depot and Over-Track Buildings
Authors: Wang Tingting , Jiang Bolong , Sun Xiaojing
Published: August 2023

To predict and control the train-induced vibration in depot buildings, a case study of the depot of Tianjin Metro, Line 5, was conducted. The platform of the depot has been constructed and is in use, and the construction of over-track buildings has not been completed. Firstly, an in situ measurement was performed to obtain the train loads and validate the numerical model. Secondly, a finite element model of the track–soil–depot structure was established. The train was simplified as a series of two spring-mass models and the train load was simulated using the measured rail acceleration. The calculated results were validated by the measurement data. To predict the vibration responses of the over-track building to be built, a sub-system of the over-track building was added to the numerical model. Finally, the vibration control effect of vibration isolation bearings was discussed. The results indicate that vibrations exceeded guideline limits without mitigation measures in some rooms of the over-track building. The dominant frequency of the building floors is 31.5 Hz. Vibration isolation bearings effectively mitigated the vibrations, and the IL reached approximately 7–15 dB at about 31.5 Hz.
Research on Lateral Performance of Corrugated Steel Plate Shear Walls Connected with Beams Only under Horizontal Loads
Authors: Cao Qiang , Huang Jingyu , Gu Baonan
Published: August 2023

This paper investigates the lateral performance of corrugated steel plate shear walls with corrugation laid vertically connected with beams only (CboSPSW). A numerical model for the CboSPSW was developed, and verified by a laboratory test. Based on the verified numerical model, extensive parametric analyses were carried out to investigate the key parameters’ effects on the shear performance of CboSPSWs, including the height ratio, aspect ratio, opening rate, and surrounding frame stiffness. In these parametric analyses, strength and lateral stiffness losses of the corrugated steel plate (CSP), buckling, and failure modes of the shear walls were investigated. In addition to these, a simplified model for the CboSPSW was developed to predict the shear performance of the shear wall. The results show that the CboSPSWs exhibit large strength, initial stiffness, and good displacement ductility. Compared with the corrugated steel plate shear walls with vertical corrugated steel plates connected with beams and columns (CbcSPSW), the strength of the CSPs decreased 15–28% in the CboSPSWs. The free edges of the CSPs in the CboSPSWs should be strengthened by adding stiffeners on one side or two sides of the CSPs in practical projects. The aspect ratio and opening rate of the CSPs should be controlled for strength decreases of the CSPs. The modified strip model can be used to predict shear performance of the CboSPSW with a reasonable accuracy.
Structural Analysis of Masonry Square Vaults in the Italian Region of Apulia
Authors: De Fabrizio Maristella , Mallardo Vincenzo
Published: August 2023

This research concerns the introduction and the structural analysis of masonry vaults in Puglia, a region in the south part of Italy, built between the sixteenth and the seventeen centuries. Such vaults have special shapes that make them unique in the overview of the masonry vaults spread all over the world. The present paper intends to shed light on the mechanical behavior of two typical vaults in Puglia, the “volta a spigoli” (edge vault) and the “volta a squadro” (square vault). There are many contributions that explore the mechanical behavior of the classical vaults, but to the authors’ knowledge, this is the first attempt investigating the “volta a squadro”. The paper describes the adopted research methods. First, a building survey is carried out with the integration of previous geometry acquisitions performed by local stakeholders. Then, the analysis is pursued by a non-linear approach that suitably inserts cracks where stress concentrations occur. Two meaningful load conditions are taken into account and numerically investigated. Under vertical loads, numerical results have inferred the surveyed cracks and concluded that the safety factor is much higher than one. On the other hand, under the maximum seismic load, the safety factor is estimated to be about 30%. This work is the very first investigation on the structural performance of a “volta a squadro”.
The Role of the Active Design Approach in Improving the Environmental Psychology of a Healthy Built Environment: The Case of a University Campus
Authors: Azeez Sweyda Abdullah , Mustafa Faris Ali , Ahmed Rizgar Maghded
Published: August 2023

Environmental psychology plays a vital role in the overall development of human health. Student activism and health concerns have arisen about the human health costs associated with a healthy built environment. This research focuses on recent design “trends”, active designs, and their relationship to environmental psychology and a healthy campus. This study examines the role of the active design approach in improving the environmental psychology of universities to achieve a healthy campus for students by hypothesising physical activity comprises three categories: physically active (body), mentally active (emotions), and socially active (group). The total number of student participants was 428 from ten university campuses. The methodology included a questionnaire survey with statistical analyses, ANOVA tests, and factor analyses. The results of this study reveal that students are more active outside campus than inside campus. Students are more interested in social activity than in mental and physical activities. In addition, the obstacles to students’ physical inactivity are a lack of time, lack of opportunities on campus, and the psychological feeling of anxiety, depression, and tension due to social activities and university work performances. In conclusion, a model is designed to demonstrate the relationship between environmental psychology and active design variables.
Perception of Color in Architecture and Urban Space
Authors: Jaglarz Anna
Published: August 2023

The various colors and color combinations in an urban environment are perceived and experienced individually. The article indicates the important role of color in shaping architecture and urban space. The paper discusses the theories of color harmony as an aesthetic principle in architectural design. The results of the research have proven the significant role of color as an element of the composition of urban space affecting the observer. This translates into the importance of color in architectural design, taking into account the difficulty and ambiguity in predicting color aesthetics; the impact of color on humans; and its cognitive, emotional and behavioral effects. The information and conclusions obtained as a result of the literature studies and the results of the survey gave the basis for determining various color strategies in shaping architecture and the effects that we can achieve in urban space thanks to a well-thought-out, conscious use of colors. The research findings also indicate that it is necessary to supplement architectural education programs with broadly understood knowledge about color and its impact on humans. The implemented activities are a response to current ideas and directions in designing and teaching architectural design outlined and suggested as part of the New European Bauhaus initiative.
Towards a Healthy Architecture: A New Paradigm in the Design and Construction of Buildings
Authors: Quesada-García Santiago , Valero-Flores Pablo , Lozano-Gómez María
Published: August 2023

The recent COVID-19 pandemic has catalysed a new awareness of what living and working spaces should look like from a different perspective, and healthier cities and architecture have arisen because of inescapable public demand. Society has become clearly aware that there are still unhealthy concentrations within its environment. Spaces in cities are still being built that can favour the spread of diseases, in addition to using harmful construction materials. Living spaces must not only be sustainable, functional, and aesthetically beautiful but also comfortable, safe, and accessible, and, above all, they must be healthy. Healthy architecture has emerged as a new paradigm. This is the subject area of this work. This paper describes and develops the nature of this concept and proposes a novel definition of healthy architecture, aiming to compile state-of-the-art knowledge with a qualitative empirical and multi-method process, using case studies. This article provides a global perspective on new approaches and proposes a Decalogue with the basic principles that an environment or building must comply with in order to be healthy. The main contribution is to establish the basis for the creation of a new healthy architecture epistemology, focussing on cognitive, emotional, and physiological stimuli. This paper can help health professionals, designers, and architects, as well as companies and public administrations, to follow an innovative path in the planning of healthier cities and buildings.