bluuebunny/crossref_metadata_2025 huggingface dataset:
Epidemiology of Multiple sclerosis in Saudi Arabia, a Descriptive study
Authors: Jumah Mohammed Al , Bunyan R. , Otaibi H. Al , Towaijri G. Al , Karim A. , Malik Y. Al , Kalakatawi M. , Alrajeh S. , Mejally M. Al , Gahtani H. Al , Almubarak A. , Cupler E. , Alawi S. , Qureshi S. , Naharir S. , Almalki A. , Alhazzani A. , Althubaiti I. , Alzahrani N. , Alradhi G. , Saeedi J. , Ishak S. , Almudaiheem H. , Elmetwally A. , Jedaie A. Al
Published: November 2019

Introduction In 2015, the first nationwide, multi-center MS registry was initiated in the Kingdom of Saudi Arabia with an objective to describe current epidemiology, disease patterns, and clinical characteristics of MS in Saudi Arabia. This article aims to report initial findings of the registry and report regional prevalence of MS. Method The registry included all MS patients with confirmed MS diagnosis according to 2010 McDonald Criteria. It aimed to identify and recruit all healthcare institutions treating MS patients in the Kingdom, and collect data such as demographics, clinical characteristics (disease onset, diagnosis, disease course, relapse rate, and disability measures), family history, and treatments. All the included sites have obtained IRB/EC approvals for participating in the registry. Results As of September 2018, the registry has included 20 hospitals from the different regions across the Kingdom and has collected comprehensive data on 2,516 patients from those hospitals, with mean age 33.42 (SD: 9.70) and 66.5% being females. The reported prevalence of MS for those hospitals is estimated to be 7.70/100,000 total population and 11.80/100,000 Saudi nationals. Assuming that the prevalence is the same across all the hospitals in the particular region, we projected the prevalence for total hospitals capable of diagnosing and treating MS and accordingly projected the total prevalence of MS as 40.40/100,000 total population and 61.95/100,000 Saudi nationals. The prevalence was reported 77.5% among people age <40 and below. The female to male ratio was 2:1. The prevalence was higher among female, young and educated individuals across all five regions of Saudi Arabia. Conclusion The prevalence of MS has significantly increased in Saudi Arabia but is still much lower than western and other neighboring countries like Kuwait, Qatar, and the UAE. However, compared to the past rates, Saudi Arabia’s projected prevalence of MS through this national study is 40.40/100,000population, putting them above the low risk zone as per Kurtzke classification. The projected prevalence is estimated to be much higher among Saudi nationals only (61.95/100,000Saudi-nationals). The prevalence was higher among female, younger, and educated individuals. Further studies are needed to asses the risk factors associated with increased prevalence in Saudi Arabia.
Duck enteritis virus UL21 is a late gene and encodes a protein that interacts with pUL16
Authors: Yang Linjiang , Wang Mingshu , Zeng Chunhui , Shi Yong , Cheng Anchun , Liu Mafeng , Zhu Dekang , Chen Shun , Jia Renyong , Yang Qiao , Wu Ying , Zhang Shaqiu , Zhao Xinxin , Huang Juan , Liu Yunya , Ou Xumin , Mao Sai , Yu Yanling , Zhang Ling , Tian Bin , Pan Leichang , Rehman Mujeeb Ur , Chen Xiaoyue
Published: November 2019

Background pUL21 is a conserved protein of Alphaherpesvirinae and exhibits multiple important functions. The C-terminus of pUL21 in other members of this subfamily has RNA-binding ability; this domain contributes to pseudorabies virus (PRV) retrograde axonal transport in vitro and in vivo and participates in newly replicated viral DNA packaging and intracellular virus transport. However, little is known about duck enteritis virus (DEV) pUL21. Methods In our study, recombinant pUL21 was expressed using apET-32c (+) vector in Escherichia coli BL21 cells induced with 0.4 mM isopropyl β-D-thiogalactoside for 8 h at 30°C. The antibody for indirect immunofluorescence (IFA) and western blotting (WB) analysis were then prepared. Pharmacological inhibition, WB and quantitative reverse transcription PCR (RT-qPCR) were performed. A coimmunoprecipitation (CO-IP) assay was conducted to test the interaction between pUL21 and pUL16. Results We verified that DEV UL21 is a γ2 gene and encodes a structural protein. Moreover, we observed that pUL21 localized to the nucleus and cytoplasm. DEV pUL21 interacted with pUL16 and formed a complex in transfected human embryonic kidney (HEK) 293T cells and DEV-infected duck embryo fibroblasts (DEFs). These results were further confirmed by CO-IP assays. Conclusions The DEV UL21 gene is a late gene, and the pUL21 localizes to the nucleus and cytoplasm. DEV UL21 is a virion component. In addition, pUL21 can interacts with pUL16. These ﬁndings provide insight into the characteristics of UL21 and the interaction between pUL21 and binding partner pUL16. Our study enhances understanding of DEV pUL21.
Proteomic Study of Hypothalamus in Pigs Exposed to Heat Stress
Authors: Yu Tianyue , Yong Yan-Hong , Li Jun-yu , Fang Biao , Hu Can-ying , Wu Lian-yun , Gooneratne Ravi , Patil Yadnyavalkya , Ju Xianghong
Published: November 2019

Background: With evidence of warming climates, it is important to understand the effects of heat stress in farm animals in order to minimize production losses. Study of changes in the brain proteome induced by heat stress may aid in understanding how heat stress impacts brain function. The hypothalamus is a key region in the brain that controls the pituitary gland, which is responsible for the secretion of several important hormones. Result: In this study, we examined the hypothalamic protein profile of ten pigs (30–40 kg body weight), 5 of which were subjected to heat stress (35 ± 1°C; relative humidity = 90%) and 5 acting as controls (28 ± 3°C; RH = 90%). The isobaric tags for relative and absolute quantification (iTRAQ) analysis of the hypothalamus identified 1710 peptides corresponding to 360 proteins, and 295 deferentially expressed proteins (DEPs), 148 of which were up-regulated and 147 down-regulated in heat-stressed animals. Ingenuity Pathway Analysis software predicted 30 canonical pathways, 4 functional groups, and 4 regulatory networks of interest and the DEPs mainly concentrated in the cytoskeleton of the pig hypothalamus during heat stress. Conclusions: The upstream regulators of these 295 DEPs in the hypothalamus of the pig under HS are mainly transcriptional regulators, chemical drugs, and sRNA. This study provides reference data for further study of the mechanism of HS on hypothalamic physiology and metabolism(Illustration 1).
Unilateral visual impairment in a patient undergoing chemotherapy: a case report and clinical findings
Authors: Yuan Xia , Feng Yuliang , Li Dan , Li Mei
Published: November 2019

Visual impairment occurred as an infrequent form of chemotherapeutic toxicity and was often underestimated despite of several reports. We described a case of acute unilateral visual impairment after one cycle of intravenous chemotherapy of a normal dose, aiming at raising attention to chemotherapy-induced ocular toxicity. Case presentation: The patient developed a progressive vision loss in the right eye during the chemotherapy. After one cycle of intravenous chemotherapy, her visual acuity decreased by 0.6 in the right eye (VOD=0.4) compared to the previous value of 1.0 (VOD=1.0). No evidence of ocular infiltration was observed from the cerebral magnetic resonance imaging (MRI). During her follow-up period, we documented the ophthalmologic examinations including visual acuity, visual field (VF), visual evoked potential (VEP), electroretinogram (ERG), fundus photograph (FP), fundus fluorescein angiography (FFA) and optical coherence tomography (OCT). Ophthalmoscope examination and fundus photograph showed optic disc edema, fuzzy boundary and linear hemorrhages in her right eye. Fundus fluorescein angiography (FFA) revealed capillary underdevelopment at the nasal and superior temporal area of the optic disc in the early phase and capillary fluorescein leakage in the late phase. The result of VEP test suggested the impaired function of the optic nerve. Thus, a diagnosis of nonarteritic anterior ischemic optic neuropathy (NAION) was made by the ophthalmologist according to these results. The patient was prescribed prednisone combined with neuroprotective drugs, which did not work. After the cessation of chemotherapy, her impaired vision gradually recovered. Conclusions: This is the first reported case of acute visual impairment in a patient who underwent chemotherapy of a normal dose. It is indicated that while receiving benefits from chemotherapy, cancer patients simultaneously suffer from the risk of vision loss. Key words: Vision loss, Chemotherapy, Nonarteritic anterior ischemic optic neuropathy
Full-length transcriptome sequences of Agropyron cristatum facilitate the prediction of putative genes for thousand-grain weight in a wheat-A. cristatum translocation line
Authors: Author) Shenghui Zhou(Former Corresponding , Zhang Jinpeng , Han Haiming , Zhang Jing , Huihui Ma , Zhang Zhi , Lu Yuqing , Liu Weihua , Yang Xinming , Li Xiuquan , Author) Lihui Li(New Corresponding
Published: November 2019

Agropyron cristatum (L.) Gaertn. (2n = 4x = 28; genomes PPPP) is a wild relative of common wheat (Triticum aestivum L.) and provides many desirable genetic resources for wheat improvement. However, there is still a lack of reference genome and transcriptome information for A. cristatum, which severely impedes functional and molecular breeding studies.Results Single-molecule long-read sequencing technology from Pacific Biosciences (PacBio) was used to sequence full-length cDNA from a mixture of leaves, roots, stems and caryopses and constructed the first full-length transcriptome dataset of A. cristatum, which comprised 44,372 transcripts. As expected, the PacBio transcripts were generally longer and more complete than the transcripts assembled via the Illumina sequencing platform in previous studies. By analyzing RNA-Seq data, we identified tissue-enriched transcripts and assessed their GO term enrichment; the results indicated that tissue-enriched transcripts were enriched for particular molecular functions that varied by tissue. We identified 3,398 novel and 1,352 A. cristatum-specific transcripts compared with the wheat gene model set. To better apply this A. cristatum transcriptome, the A. cristatum transcripts were integrated with the wheat genome as a reference sequence to try to identify candidate A. cristatum transcripts associated with thousand-grain weight in a wheat-A. cristatum translocation line, Pubing 3035.Conclusions Full-length transcriptome sequences were used in our study. The present study not only provides comprehensive transcriptomic insights and information for A. cristatum but also proposes a new method for exploring the functional genes of wheat relatives under a wheat genetic background. The sequence data have been deposited in the NCBI under BioProject accession number PRJNA534411.
The ‘tamed’ mountains: from terrifying and uninhabited environments to places of the soul and religious spaces
Authors: Cardarelli Francesco M.
Published: November 2019

The survey, by using the methods of historical research, focuses on the transformation of mountains, which, from terrifying and uninhabited environments, gradually became among the most significant places of the soul and religious spaces. Resorting to historical, literary and archival sources, the study, of an interdisciplinary nature, aims to reconstruct a little-known aspect of Italian history, in particular of history of culture and ideas.Mountains, which constitute a significant portion of Italy, were considered by the Ancients antithetical to human civilization. With Christianity a new image of mountains made its way, where, according to the Scriptures, some decisive episodes of the history of salvation had taken place. The hermits who wanted to dedicate themselves only to God began to take refuge in the mountains, but the ideological prejudice transmitted by classical authors remained fixed in the collective imagination and upland areas continued for centuries to be misunderstood and rarely visited.An important turning point came with two religious orders, the Camaldolese and the Franciscans, who gave a fundamental contribution to the ‘taming’ of mountains. Thanks to Saint Romuald, in Camaldoli, on the Tuscan-Romagnolo Apennines, an experience was born that combined evangelization, forest management and interventions on the mountain territory. In their settlements the Camaldolese, while cultivating the fields, regulating the waters and taking care of the woods, at the same time promoted education, culture and work for the people who lived nearby. From Assisi and the mountains of Umbria began the revolution of Saint Francis, which involved men and women, animals, fields, fruits, flowers, forests, rocks: all like God’s creatures. Thus the Apennine mountains, the true backbone of the Italian peninsula, became increasingly popular open spaces, places of meeting and of spiritual and material life, based on a balanced and exemplary relationship between man and nature.
The lighting refurbishment of places of worship: The case study of the Church of “Santa Maria di Piedigrotta”
Authors: Roberta Laffi , Sergio Sibilio , Michelangelo Scorpio , Giovanni Ciampi , Antonio Rosato , Spanodimitriou Yorgos
Published: November 2019

Christian church buildings constitute most of the architectural heritage in Italy. In this paper, the case study of the exterior lighting renewal of the Church of “Santa Maria di Piedigrotta”, located in Napoli, is discussed. The lighting project was carried out with the goal of emphasizing the original hierarchies of the building details, that can often be difficult to understand with the current lighting system. The study started with the analysis of the architectural features of the façades and belfry as well as the existing lighting system. In order to allow for the comparison and optimization of the various lighting design solutions, a virtual model of the church was realized in the simulation software DIALuxEvo. In the most suitable concept, both diffused and accent lighting were integrated, allowing for a correct perception of the whole of the façades of Church, thus highlighting its most valuable elements. The results obtained have responded positively to the enhancement and conservation of the historical-artistic works, while also resulting in energy saving. Moreover, the Standards of Law restrictions on “light pollution towards the sky” for historical and monumental buildings have been respected.
Uso de productos de aseo y limpieza en hogares de Santa Marta: realidades y posibilidades para un consumo sostenible
Authors: Daza-Corredor Alexander , Viloria-Escobar Javier De Jesús , Rodríguez-Pacheco Farid Leonardo , Miranda-Terraza Luis Francisco
Published: November 2019

Este estudio identifica algunas perspectivas, preferencias y comportamientos de consumidoresen Santa Marta frente al uso de productos de aseo y limpieza. La investigación parte de lareflexión teórica sobre el concepto de desarrollo sostenible y, en lo fundamental, se configuraen la tipología mixta en la medida que armoniza encuadres de las investigaciones cuantitativa ycualitativa para tener una mejor comprensión del fenómeno de la sostenibilidad desde elconsumo y la producción, los cuales se enmarcan en el Objetivo de Desarrollo Sostenible No.12. Los resultados muestran que los consumidores son conscientes del impacto que generanestos productos sobre el ambiente. Desde estas implicaciones, se plantea una sustitución de losproductos de aseo tradicionales por productos emergentes que son mucho más amigables con elmedio ambiente.
Ellen Kennedy, Carl Schmitt en la República de Weimar La quiebra de una constitución, traducción de Pedro Lombana Falcón, Madrid, Tecnos, 2012, 283 pp.
Authors: Rodríguez Martínez Christian
Published: November 2019

Estudiar a los clásicos de la teoría política y del derecho constitucional, resulta ser un reto académico bastante complicado, más si se trata de autores tan controversiales como Carl Schmitt, sin embargo, el libro de la profesora Ellen Kennedy ha sabido superar ese reto. Carl Schmitt que logró vivir hasta la década de los ochenta del siglo pasado, ha sido un autor bastante criticado por haber pertenecido al Partido Nacional Socialista de los Trabajadores de Alemania desde el 01 de mayo de 1930 bajo el número 2.098.860 y por ser considerado el jurista del nazismo, a pesar de esto la profesora de Pennsylvania se atreve a estudiar su obra y su pensamiento resaltando su aporte principalmente al derecho constitucional contemporáneo.
Comparative Studies on Hormonal Changes and Metabolic Syndrome in Perimenopausal and Premenopausal Igbo Women in Enugu Metropolis Nigeria: A Cross-sectional Study
Authors: Ikegwuonu Chinwe Ifeoma , Ikenna Uchendu Kingsley , Nwabueze Okonkwo Innocent , Betina Mba Chika , Chukwudi Maduka Ignatius , Chinedum Onyenekwe Charles
Published: November 2019

Background and Objective:

Few studies have focused on the epidemiology of perimenopausal syndrome, and its prevalence in African women is concerningly high. This study investigated selected biochemical parameters, hormonal changes, and possible metabolic syndrome (MetS) in perimenopausal and premenopausal women among Igbo women in Enugu, Southeast of Nigeria.

Methods:

This study was conducted between March 2018 and November 2018. A total of 200 apparently healthy women, comprising 120 perimenopausal women (mean age 50 years) and 80 premenopausal women (mean age 35 years), living in Enugu, were randomly recruited for this study. Anthropometric indices (blood pressure, waist circumference, weight, and height) of these women were measured. Fasting blood samples were collected and used for measurement of luteinizing hormone (LH), estradiol (E2), follicle stimulating hormone (FSH), fasting plasma glucose (FPG), and lipid profile using standard methods. MetS in the perimenopausal and premenopausal women was observed using three different criteria: the National Cholesterol Education Program- Adult Treatment Panel 111 (NCEP-ATP 111), the World Health Organization (WHO), and International Diabetes Federation (IDF). Student’s t-test and Chi-square were used to compare continuous and categorical variables.

Results:

There were significantly (p<0.05) higher values of blood pressure (systolic and diastolic), FPG, waist circumference, LH, FSH, total cholesterol, and LDL-C, but significantly (p<0.05) lower values of estradiol in perimenopausal women as compared to premenopausal women. The incidence of MetS was higher in perimenopausal women as compared to premenopausal women in all the three criteria studied.

Interpretation and Conclusion:

Perimenopausal women have a higher risk for the development of metabolic syndrome-associated diseases than premenopausal women.
Polyphenolic Compounds and Gut Microbiome in Cardiovascular Diseases
Authors: McGrail Lindsay , Garelnabi Mahdi
Published: November 2019

The onset of Cardiovascular Disease (CVD) is known to be associated with multiple risk factors related to exogenous exposures on predisposed genetic makeup. Diet and lifestyle have a cascade effect on microbiota biodiversity, thus impacting inflammation and heart health. Atherosclerosis is a type of CVD where chronic inflammation contributes to plaque buildup in the arteries resulting in narrowed blood vessels, which obstruct blood flow. Polyphenolic compounds, including flavonoids, most commonly consumed in the form of plants, have been identified to have various mechanisms of action to reduce the inflammatory response in the body. Flavonoids provide a variety of nutraceutical functions including antioxidant, antimicrobial, anti-inflammatory, antiangiogenic, antitumor, and improved pharmacokinetic properties. Therefore, the medicinal use of polyphenolic compounds as an intervention for the inflammatory response, especially relating to the gut microbiome, may significantly reduce the risk of atherosclerotic plaque development and disease onset. This review addresses the role of polyphenolic compounds and gut microbiome in cardiovascular disease. Research studies conducted in cells and animals were reviewed. These studies clearly illustrate that dietary polyphenolic compounds influence resident gut microbiota thus they are associated with the prevention of atherosclerosis progression. Further research in this field is warranted to identify potential gut microbiome mediated therapeutic approaches for CVD.
The Potential Use of Anticancer Peptides (ACPs) in the Treatment of Hepatocellular Carcinoma
Authors: Ng Chu Xin , Lee Sau Har
Published: November 2019

Peptides have acquired increasing interest as promising therapeutics, particularly as anticancer alternatives during recent years. They have been reported to demonstrate incredible anticancer potentials due to their low manufacturing cost, ease of synthesis and great specificity and selectivity. Hepatocellular carcinoma (HCC) is among the leading cause of cancer death globally, and the effectiveness of current liver treatment has turned out to be a critical issue in treating the disease efficiently. Hence, new interventions are being explored for the treatment of hepatocellular carcinoma. Anticancer peptides (ACPs) were first identified as part of the innate immune system of living organisms, demonstrating promising activity against infectious diseases. Differentiated beyond the traditional effort on endogenous human peptides, the discovery of peptide drugs has evolved to rely more on isolation from other natural sources or through the medicinal chemistry approach. Up to the present time, the pharmaceutical industry intends to conduct more clinical trials for the development of peptides as alternative therapy since peptides possess numerous advantages such as high selectivity and efficacy against cancers over normal tissues, as well as a broad spectrum of anticancer activity. In this review, we present an overview of the literature concerning peptide’s physicochemical properties and describe the contemporary status of several anticancer peptides currently engaged in clinical trials for the treatment of hepatocellular carcinoma.
Synthesis of Silver Nanoparticles using Euphorbia wallichii Extract and Assessment of their Bio-functionalities
Authors: Phull Abdul-Rehman , Ali Attarad , Ali Akhtar , Abbasi Sanaullah , Zia Muhammad , Khaskheli Muhammad H. , Haq Ihsan ul , Kamal Mohammad A.
Published: November 2019

Background:

Silver nanoparticles synthesized by the bio-green method have been applied
to various biomedical applications. These procedures are simple, eco-friendly and serve as an
alternative to complex chemical methods for the preparation of nanomaterials.

Objective:

: In the present study, phytosynthesis of silver nanoparticles, to examine their antioxidant
potential, toxic effects towards bacterial-, fungal-strains, brine shrimp nauplii and cancer cells was
focused.

Methods:

Methanolic extract of Euphorbia wallichii roots was used for the synthesis of silver
nanoparticles. The synthesis was monitored and confirmed by UV-visible spectroscopy, Fourier
Transform Infra-Red (FTIR) spectrometric analysis, Field Emission Scanning Electron Microscope
(FESEM), Energy Dispersive X-ray (EDX) and X-Ray Powder Diffraction (XRD).

Results:

The synthesized particles were average 63±8 nm in size. Involvement of phenolic
(46.7±2.4 µg GAE/mg) and flavonoid (11.7±1.2 µg QE/mg) compounds as capping agents was
also measured. Nanoparticles showed antioxidant properties in terms of free radical scavenging
potential (59.63±1.0 %), reducing power (44.52±1.34 µg AAE/mg) and total antioxidant capacity
(60.48±2.2 µg AAE/mg). The nanoparticles showed potent cytotoxic effects against brine shrimp
nauplii (LD50 66.83 µg/ml), proliferation and cell death of HeLa cells as determined by MTT
(LD50 0.3923 µg/ml) and TUNEL assays, respectively. Antimicrobial results revealed that silver
nanoparticles were found to be more potent against pathogenic fungal (maximum active against A.
fumigatus, MIC 15 µg/disc) and bacterial strains (maximum active against S. aureus, MIC 3.33
μg/disc) than the E. wallichii extract alone.

Conclusion:

These results support the advantages of using an eco-friendly and cost-effective
method for synthesis of nanoparticles with antioxidant, cytotoxic and antimicrobial potential.
Probiotic Frozen Yoghurt Supplemented with Coconut Flour Green Nanoparticles
Authors: Salama Heba H. , Abdelhamid Samy M. , Abd-Rabou Nabil S.
Published: November 2019

Background:

Frozen yoghurt is a suitable vehicle to deliver bioactive compounds and beneficial
microorganisms, and to develop new functional dairy products.

Methods:

Bifidobacterium bifidum was used in the manufacture of frozen yoghurt, whereas skim milk
powder was substituted by Nanoparticles Coconut Flour (NCF) and Coconut Flour (CF). The physicochemical,
microbiological and sensory properties were assessed for frozen yoghurt from different treatments.

Results:

The prepared NCF by ball-milling had sizes that range between 81.96nm to 83.53nm. The addition
of NCF affected variably the pH values, moisture content, the overrun, fiber content, freezing
points and viscosity of the prepared frozen yoghurt depending on the ratio of substituted skim milk.

:

Also, the addition of NCF improved the viability of Bifidobacterium bifidum, Bifidobacterium breve,
Streptococci, and Lactobacilli and total bacterial count of frozen yoghurt during frozen storage. The
addition of NCF improved the sensory properties of frozen yoghurt.

Conclusion:

The use of Nanoparticles Coconut Flour (NCF) and Bifidobacterium sp., in the preparation
of frozen yoghurt improved its physicochemical, microbiological and sensory properties.
Development and Characterization of Oral Nanosuspension Using Esomeprazole Magnesium Trihydrate
Authors: Goel Surya , Agarwal Vijay , Sachdeva Monika
Published: November 2019

Background:

Nanosuspension has arisen as a lucrative, remunerative, as well as a
potent approach to improve the solubility and dissolution rate of poorly soluble drug entities.
Several challenges are still present in this technology which need more research.

Objective:

The prime aim of this research work is to develop, optimize and characterize the oral
nanosuspension using esomeprazole magnesium trihydrate as a drug candidate.

Methods:

The drug nanosuspensions were prepared using both approaches; Top-down and
Bottom-up as the combinational approach. Poloxamer 188 was used as a stabilizer in this study.
All the important formulation variables, like concentration of stabilizers that may influence characteristics
of the nanosuspensions, were optimized. Formulation screening was performed using the
optimization process, and the optimized nanosuspension was evaluated for its particle size, polydispersity
index, zeta potential, shape, in vitro drug release and stability.

Results:

For optimization of drug nanosuspension, the effect of Poloxamer 188 concentration and
esomeprazole concentration was investigated and the optimal values were 0.3% w/v and 4 mg/ml,
respectively. The particle size of nanosuspensions was in the range of 185 to 1048 nm with
varying the zeta potential values from -11.2 to -27.5 mV. The in vitro dissolution rate of
esomeprazole was increased up to 3-folds, approximately (92% in 90 min) as compared with crude
esomeprazole drug (31% in 90 min) due to the decrease in particle size.

Conclusion:

The result indicated that the combination of top-down and bottom-up approach used
for preparing the oral nanosuspension is a suitable approach for poorly aqueous soluble drug moieties
like esomeprazole magnesium.
Implementation: The Next Giant Hurdle to Clinical Transformation With Digital Health
Authors: Buis Lorraine
Published: November 2019

Clinical implementation of digital health is a major hurdle to overcome in the coming years. Considering the role of the Journal of Medical Internet Research in the past 20 years and looking toward the journal’s future, this viewpoint acknowledges the vision of medicine and the role that digital health plays in that vision. It also highlights barriers to implementation of digital health as an obstacle to achieving that vision. In particular, this paper focuses on how digital health research must start looking toward implementation as an area of inquiry and the role that the Journal of Medical Internet Research and its' sister journals from JMIR Publications can play in this process.
A Web-Based Human Papillomavirus Vaccination Intervention for Young Gay, Bisexual, and Other Men Who Have Sex With Men: Protocol for a Randomized Controlled Trial
Authors: Reiter Paul L , Gower Amy L , Kiss Dale E , Malone Molly A , Katz Mira L , Bauermeister Jose A , Shoben Abigail B , Paskett Electra D , McRee Annie-Laurie
Published: November 2019

Background

Gay, bisexual, and other men who have sex with men experience several disparities related to human papillomavirus (HPV) infection, including high incidence rates of anal cancer. Although the HPV vaccine is currently recommended for young adults, HPV vaccine coverage is modest among young gay, bisexual, and other men who have sex with men (YGBMSM).

Objective

We describe the design and methods for a randomized controlled trial (RCT) to rigorously evaluate Outsmart HPV, a population-targeted, individually tailored, Web-based HPV vaccination intervention for YGBMSM. The RCT is designed to determine the efficacy of the intervention, the mechanism by which the intervention has an effect (ie, mediation), and whether efficacy varies by participant characteristics (ie, moderation).

Methods

Outsmart HPV was previously developed and pilot-tested. This study is a 3-arm prospective RCT that will enroll a projected 1995 YGBMSM who are aged 18 to 25 years, live in the United States, and have not received any doses of the HPV vaccine. Participants will be recruited by means of paid advertisements on social media sites and randomized to receive (1) standard information on the Web about HPV vaccine (control group), (2) Outsmart HPV content on the Web with monthly unidirectional vaccination reminders sent via text messages, or (3) Outsmart HPV content on the Web with monthly interactive vaccination reminders sent via text messages. Participants will complete Web-based surveys at 4 time points during the study: baseline, immediately after engaging with Web-based content, 3 months after randomization, and 9 months after randomization. Primary outcomes will include both HPV vaccine initiation (ie, receipt of 1 or more doses of the HPV vaccine) and completion (receipt of all 3 doses recommended for this age range). We will examine constructs from the intervention’s theoretical framework as potential mediators and demographic and health-related characteristics as potential moderators of intervention effects.

Results

The institutional review board at The Ohio State University has approved the study. Materials have been developed and finalized for all study groups. Recruitment for the RCT began in fall 2019.

Conclusions

If shown to be efficacious, Outsmart HPV has the potential to fill an important gap by promoting HPV vaccination among a population at increased risk of HPV infection and HPV-related disease.

Trial Registration

ClinicalTrials.gov NCT04032106; http://clinicaltrials.gov/show/NCT04032106

International Registered Report Identifier (IRRID)

PRR1-10.2196/16294
Evaluation of Yield and Yield Components of Two Potato Cultivars in Khorasan Razavi Province of Iran
Authors: Foroghian Setareh , Asgharipour Mohammad Reza , Davoodi Mehdi Ghiafeh
Published: November 2019

In order to study the yield and yield components of two potato cultivars, an experiment was conducted as a split plot based on a randomized complete block design with three replicates. The experiment was performed in two locations, Jolgeh-Rokh district, and Fariman city, in professional farmers’ fields in Khoarasan Razavi province. The main plots consisted of two potato cultivars, Agria and Fontane cultivars (medium maturing), which were identified as the main cultivars used in chips production factories in the Province. Our results showed higher potential of Agria cultivar for production of stems per plant compared to Fontana cultivar. Both stem number and tuber number per plant along with tuber weight and tuber yield were higher in Fariman location than in Jolgeh-Rokh.
Новинки аналитического оборудования компании Shimadzu
Authors: Фармаковский Д.А. , Цупрева В.Н.
Published: November 2019

Корпорация Shimadzu, один из лидеров аналитического приборостроения, постоянно работает над расширением и совершенствованием модельного ряда оборудования. Новые модели приборов отвечают растущим потребностям в высокой эффективности работы, точности и надежности получаемых результатов и удобства эксплуатации. В статье представлены новинки оборудования для масс-спектрометрии и молекулярной спектроскопии – наиболее востребованных на сегодняшний день классов аналитических инструментов.
Shimadzu: новинки аналитического и испытательного оборудования 2019
Authors: Борисова Т.Г. , Борисов А.В.
Published: November 2019

Компания Shimadzu работает на аналитическом рынке более ста сорока лет и является одним из мировых лидеров по производству аналитического и испытательного оборудования. Выпускаемые приборы предназначены как для рутинного анализа, так и исследования сложных проб. Оборудование Shimadzu используется в научно-­исследовательских лабораториях, аттестованных испытательных центрах, работающих в различных отраслях науки и производства: пищевой промышленности, фармацевтике, агропромышленном комплексе и др. Статья знакомит читателя с новыми приборами в области жидкостной хроматографии и испытательного оборудования, их возможностями и особенностями.
Химия‑2018. Новые «горячие» области исследований
Authors: Мильман Б.Л. , Островидова Е.В. , Журкович И.К.
Published: November 2019

Эта публикация – ​четвертая из регулярной серии статей, посвященных мониторингу наиболее «горячих» областей развития химии и, в частности, аналитической химии. Мониторинг основан на применении современных наукометрических методов, а именно статистике цитирования и совместного цитирования научных публикаций. При этом делается акцент на выявление тематики научных работ переднего края – ​фронтов исследований. Применение такой методологии позволяет сделать вывод о том, что в 2018 году продолжились интенсивные исследования и разработки в области солнечной энергетики, нанотехнологии, химического катализа. Сохранилась отчетливая тенденция к росту степени биологизации и миниатюризации химического анализа.
Las deficiencias de política de la Teoría Monetaria Moderna
Authors: Sosa Jesús
Published: November 2019

Reseña al libro de Epstein, Gerald. What’s Wrong with Modern Money Theory? A Policy Critique. Palgrave Pivot; 1st ed. 2019 edition (August 10, 2019).

 
Kualitas Akuntansi Zakat dan Infak/Sedekah di Badan Amil Zakat Nasional Jawa Timur
Authors: Anwar Achmad Syaiful Hidayat
Published: November 2019

This study aims to evaluate Zakat and Infaq/Shodaqoh (ZIS) accounting practices at Badan Amil Zakat Nasional (BAZNAS) of East Java Province. Data collecting technique was done by using open questionnaire and analyzed by using comparative descriptive technique. Based on the analysis result, it can be concluded that ZIS accounting practice in BAZNAS East Java Province has been referring to PSAK 109 but not yet fully applied. Matters not yet implemented include accounting for impairment of zakat and infaq/shodaqoh, non-refundable receipts, non-cash receipts, and ZIS disclosuresKata Kunci: Akuntansi, ZIS, BAZNAS, PSAK 109
Keseimbangan Muatan Informasi dan Keputusan Pembelian
Authors: Rofik Mochamad , Lestari Novi Puji
Published: November 2019

Paper ini membagi dua jenis muatan informasi: a) official information; dan b) secondary information. Official information adalah informasi yang diproduksi oleh pemasar dan secondary information adalah informasi yang di produksi oleh selain official information. Diskusi berfokus pada keseimbangan dan simpangan utilitas antara official information dan secondary information. Paper ini mengemukakan tiga proposisi: proposisi 1: nilai simpangan utilitas yang positif menunjukkan konsumen mendapatkan kepuasan lebih dari yang diharapkan; proposisi 2: nilai simpangan utilitas sama dengan 0 menunjukkan konsumen mendapatkan kepuasan sesuai dengan yang diharapkan; proposisi 3: nilai simpangan utilitas yang negatif menunjukkan konsumen mendapatkan kepuasan lebih rendah dari yang diharapkan.
CONHECIMENTO DA ENFERMAGEM RELACIONADO À TERAPIA ANTIMICROBIANA EM INFECÇÃO DE TRATO URINÁRIO NO CENTRO DE TERAPIA INTENSIVA
Authors: Hevilyn Ramos da Cruz Almeida Talita , Matos Santana Ricardo , Mary Andrade Teles Monteiro Nayara , Luis Almeida da Silva João , Ribeiro da Silva Ribeiro da Silva Myria
Published: November 2019

A infecção do trato urinário é caracterizada por uma variedade de condições clínicas resultante da presença de microrganismos nas vias urinárias. Em um paciente com cateter vesical de demora, o risco de infecção aumenta significativamente, portanto, necessitando do uso de antimicrobianos. O presente estudo objetivou analisar o conhecimento das (os) enfermeiras (os) em relação ao uso de antimicrobianos e resistência aos mesmos, bem como, caracterizar a população acometida com Infecção do Trato Urinário associado ao Cateter Vesical de Demora e analisar as prescrições de Enfermagem referente ao uso de antimicrobianos. Trata-se de um estudo transversal, quantitativo, descritivo, exploratório. Os dados foram coletados e analisados a partir dos registros de enfermagem de 111 prontuários e de questionário estruturado aplicado a 12 enfermeiras (os). Houve predomínio do uso de antimicrobianos da classe das Cefaslosporinas e Quinolonas correspondendo respectivamente a 30,4% e 15,9% de todas as prescrições. Dos profissionais, 67,0% relataram ter conhecimento quanto às indicações do antimicrobiano, 56,0% afirmam conhecer a posologia e 22,0% seus efeitos adversos. No entanto, em 100,0% dos prontuários não foram observados registros e prescrições de enfermagem que abordassem os cuidados quanto aos efeitos adversos, interações medicamentosas e resistência microbiana. Evidenciou-se a urgente necessidade de intervenção educativa no serviço e capacitação de profissionais para melhorar o planejamento e assistência prestada.
Volatility spillovers and dynamic correlations among foreign exchange rates and bond markets of emerging economies
Authors: Aydemir Resul , Guloglu Bulent , Saridogan Ercan
Published: November 2019

In this paper, we first examine how important historical shocks during and after the 2007-2008 global financial crisis affect the size and the persistence of volatilities among exchange rates and the ten-year bond rates of the Fragile Five countries (i.e., Brazil, India, Indonesia, South Africa and Turkey). We then investigate separately the dynamic interactions between exchange rates and the ten-year bond rates of the Fragile Five. We utilize a multivariate GARCH model (FIAPARCH-DCC model) and volatility impulse response functions to achieve these objectives. The results suggest that shocks? positive impacts on expected conditional variances of the variables are largely market-specific and different. Shocks have a more significant impact on bond markets than on foreign exchange markets. We also find that the dynamic conditional correlation series of bonds exhibit much lower correlations than those associated with exchange rate returns.
Training and Workshop Implementation of Group Counseling with Expressive Therapy Techniques for The Prevention of Students Sexual Harassment in Junior High School 16 Padang
Authors: Syahniar Syahniar , Firman Firman , Handayani Puji Gusri
Published: November 2019

The training and workshop activities are carried out based on the phenomenon of the many problems that have arisen in the global era with sophisticated and modern technology today, one of the events experienced by many junior high school students is sexual harassment both physically and verbally. For this reason, counselors and counselors must make various counseling and counseling services, one of which is group guidance services, including efforts to prevent sexual harassment among students. Group counseling services can be done with a variety of approaches, one of which is the approach and techniques of expressive therapy counseling. The expressive therapist believes that individuals are different in expressing what is in themselves, there are individuals who are more open to express what is felt in him, including communicating the anxiety he feels. The results show that there is an increase in understanding and knowledge of school counselors / school counselors, especially in terms of implementing counseling in schools. During this time in school, counseling teachers carry out counseling with traditional methods, namely asking with special techniques, but after this training the counseling teacher can conduct counseling with an expressive therapy approach.
Utiliser l’âge de la première consommation d’alcool pour prédire la consommation d’alcool, la consommation excessive d’alcool et le mélange d’alcool et de boissons énergisantes chez les élèves de 12e année en Ontario dans le cadre du projet COMPASS
Authors: Holligan Simone D. , Battista Katelyn , de Groh Margaret , Jiang Ying , Leatherdale Scott T.
Published: November 2019

Introduction

Cette étude vise à examiner l’incidence de l’âge de la première consommation d’alcool sur la consommation actuelle d’alcool et les comportements connexes chez un large échantillon de jeunes Canadiens.

Méthodologie

Cette étude descriptive et analytique a été réalisée auprès d’élèves de 12e année de l’Ontario ayant participé à l’étude de référence COMPASS de 2012 à 2017. Nous avons eu recours à la modélisation par équations d’estimation généralisées (EEG) pour établir le lien entre l’âge de la première consommation d’alcool chez les répondants et la probabilité d’une consommation ou d’une absence de consommation d’alcool, d’une consommation excessive d’alcool et du mélange d’alcool et de boissons énergisantes.

Résultats

Les élèves ayant indiqué avoir consommé de l’alcool pour la première fois entre 13 et 14 ans étaient plus susceptibles de déclarer consommer de l’alcool plutôt que de ne pas en consommer (RC = 2,80, intervalle de confiance [IC] à 95 % : 2,26 à 3,45) et étaient plus susceptibles de déclarer consommer de l’alcool de façon excessive plutôt que de ne pas en consommer de façon excessive (RC = 3,22, IC à 95 % : 2,45 à 4,25) comparativement aux élèves ayant déclaré avoir consommé de l’alcool pour la première fois à 18 ans ou plus. Les élèves ayant commencé à consommer de l’alcool à 8 ans ou moins étaient plus susceptibles de déclarer consommer de l’alcool plutôt que de ne pas en consommer (RC = 3,54, IC à IC à 95 % : 2,83 à 4,43), avoir une consommation excessive d’alcool (RC = 3,99, IC à IC à 95 % : 2,97 à 5,37) et mélanger alcool et boissons énergisantes (RC = 2,26, IC à IC à 95 % : 1,23 à 4,14) comparativement aux élèves ayant commencé à consommer de l’alcool à 18 ans ou plus.

Conclusion

La consommation d’alcool pendant les premières années de l’adolescence permet de prédire la consommation d’alcool, la consommation excessive d’alcool ainsi que la tendance à mélanger alcool et boissons énergisantes lorsque les élèves arrivent en 12e année. Ces résultats soulignent le besoin de déployer de nouveaux efforts de prévention de la consommation d’alcool.
Anchored Inflation Expectations and the Slope of the Phillips Curve
Authors:   Copenhagen Business School, Jorgensen Peter Lihn , Lansing Kevin J. ,   Federal Reserve Bank of San Francisco
Published: November 2019

We estimate a New Keynesian Phillips curve that allows for changes in the degree of anchoring of agents' subjective inflation forecasts. The estimated slope coefficient in U.S. data is stable over the period 1960 to 2019. Out-of-sample forecasts with the model resolve both the "missing disinflation puzzle" during the Great Recession and the "missing inflation puzzle" during the subsequent recovery. Using a simple New Keynesian model, we show that if agents solve a signal extraction problem to disentangle transitory versus permanent shocks to inflation, then an increase in the policy rule coefficient on inflation serves to endogenously anchor agents' inflation forecasts. Improved anchoring reduces the correlation between changes in inflation and the output gap, making the backward-looking Phillips curve appear flatter. But at the same time, improved anchoring increases the correlation between the level of inflation and the output gap, leading to a resurrection of the "original" Phillips curve. Both model predictions are consistent with U.S. data since the late 1990s.
Sudden Death by Catecholaminergic Polymorphic Ventricular Tachycardia in Children
Authors: João Milan Isabella , Mello Porto Fernando , Cury Filho Halim , Bento de Lucena Neto Adão , Marco Nogueira Lima José
Published: November 2019

Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is a severe cardiac arrhythmogenic hereditary illness, which affects children and young adults with a structurally healthy heart. Its prevalence is of one case in 10 thousand inhabitants. It is a potentially fatal illness, part of the differential diagnosis of syncope in children. The present study has the purpose of relating the case of a child that, during the investigation of convulsive syncope, presented sudden death aborted due to CPVT and to describe the diagnosis difficulties of the case, comparing with data from the literature
THE DEVELOPMENT OF CIVIL LAW PROCEDURES IN THE RESOLUTION OF DIVORCE DISPUTES IN THE RELIGIOUS COURT
Authors: Halim Abdul
Published: November 2019

Relations which appear from legal actions do not always end well. It is not seldom that it may end with conflicts or disputes which end in court. To demand for the rights which appear from those legal relations, there needs to be some procedures and regulations so that the demand of rights may be carried out according to the law. The law which regulates those things are usually called the civil law procedures. The resolution of civil disputes in court (litigation) and the resolution of civil disputes through a non-court manner (non-litigation) in the context of the divorce dispute resolution in the Religious Court, is a combination between the litigation and the nonlitigation mmethods. This is rather interesting to be studied. The interesting part is its effectivity as a preventive or a repressive effort in handling the divorce cases in the Religious Court.
Carduus acicularis Bertol. (Asteraceae) en la Península Ibérica.
Authors: Devesa Juan Antonio , Triano Enrique , Arnelas Itziar
Published: November 2019

Carduus acicularis Bertol. (Asteraceae) in the Iberian PeninsulaPalabras clave. Carduus, Asteraceae, taxonomía, flora, Península Ibérica.Key words. Carduus, Asteraceae, taxonomy, flora, Iberian Peninsula.
Sobre Ludwigia hyssopifolia (G. Don) Exell (Onagraceae) como integrante de la flora subespontánea valenciana
Authors: Ferrer-Gallego P. Pablo , Laguna Lumbreras Emilio
Published: November 2019

Ludwigia hyssopifolia (G. Don) Exell (Onagraceae) a new species for the Valencian subspontaneous flora.Palabras clave. Ludwigia hyssopifolia, Onagraceae, corología, Valencia, Península Ibérica.Key words. Ludwigia hyssopifolia, Onagraceae, chorology, Valencian province, Iberian Peninsula.
Littorella uniflora en las lagunas de Moguer (Parque Natural de Doñana, SW Península Ibérica).
Authors: García Murillo Pablo , Palacios González Manuela
Published: November 2019

Littorella uniflora in Moguer Pond Complex (Doñana Natural Park, SW Iberian Peninsula)Palabras clave. Littorella, plantas acuáticas, flora acuática, Andalucía, Doñana, Peninsula Ibérica.Key words. Littorella, aquatic plants, aquatic flora, Donana, Andalusia, Iberian Peninsula.