bluuebunny/crossref_metadata_2025 huggingface dataset:
ANTIBACTERIAL STUDIES OF ESSENTIAL OIL FROM THE FRESH LEAF OF LEMON GRASS CYMBOPOGON CITRATUS
Authors: Isyaka Sani M. , Usman Abdulazeez , Anyam John V. , Labaran Hajara S. , Bamidele Musba’u I. , Abdullahi Abdullahi Muhammad
Published: January 2025

Cymbopogon citratus, belongs to Gramineae family. This study used a microwave-assisted hydro-distillation process to extract lemongrass essential oil and examined its antimicrobial qualities. Physical characteristics of the essential oils included a yellow color, a yield percentage of 4.67%, solubility in trichloromethane, and a lemony aroma. The disc diffusion method was used to assess the oil's effectiveness. Pseudomonas aeruginosa, Klebsiella oxytoca, Staphylococcus aureus, and Escherichia coli were all susceptible to the oil's concentration-dependent antibacterial qualities. 5.72 mmL/disc was the oil's most effective concentration against E. coli, while 1.43 mmL/disc was its least effective. The zone of inhibition shrank as the concentration of oil per disc dropped, indicating that the oil's activity against all species was concentration-dependent. At concentrations of 5.72 mmL/disc, 2.86 mmL/disc, and 1.43 mmL/disc, respectively, the zone of inhibition for E. coli was 24, 11.3, and 7.7 mm. For other creatures, the pattern is the same. Pseudomonas aeruginosa had the smallest zone of inhibition, measuring 7.0, 7.0, and 5.7 mm at concentrations of 5.72 mmL/disc, 2.86 mmL/disc, and 1.43 mmL/disc, respectively. Staphylococcus aureus was 13.3, 10.3, and 9.0 mm at concentrations of 5.72 mmL/disc, 2.86 mmL/disc, and 1.43 mmL/disc, while Klebsiella oxytoca was 11.3, 9.7, and 9.0 mm at concentrations of 5.72 mmL/disc, 2.86 mmL/disc, and 1.43 mmL/disc, respectively. These results imply that lemongrass essential oil may be a viable natural substitute for synthetic antibiotics, with potential uses in medical and food preservation. It is advised that additional bioassays be conducted and contrasted with the results obtained from alternative...
Felnőttoktatással a pozitív társadalmi változásokért és a személyes kiteljesedésért
Authors: Farkas Éva
Published: January 2025

A Felnőttoktatás és Továbbképzés Hírességeinek Nemzetközi Csarnoka (International
Adult and Continuing Education Hall of Fame, továbbiakban Hírességek Csarnoka) 2024.
november 7-9. között a csodálatos Firenzében szervezte első nagyszabású konferenciáját.
A felnőttoktatás revitalizálása a pozitív társadalmi változásokért és a személyes
kiteljesedésért (Revitalising Adult Continuing Education for Positive Social Changes and
Personal Fulfilment) címet viselő konferencia több szempontból is egyedülálló volt.  A
konferenciára a felnőttkori tanulással és oktatással foglalkozó legjelentősebb európai
és észak-amerikai szervezetek, illetve folyóiratok kaptak meghívást. A konferencia abban
is eltért a hagyományos keretektől, hogy csak két plenáris előadás volt, és a résztvevők
tíz munkacsoportban vitatták meg az együttműködés és továbblépés jövőbeli lehetőségeit.
Нелинейная поверхность разжижения дисперсной среды в многомерном пространстве параметров
Authors:   Московский государственный технический университет им. Н.Э. Баумана, Москва, Россия, Тишин Н.Р. ,   АО МОСТДОРГЕОТРЕСТ, Озмидов О.Р. ,   АО МОСТДОРГЕОТРЕСТ, Гаврилович А.С. ,   АО МОСТДОРГЕОТРЕСТ, Селиванова О.С. ,   АО МОСТДОРГЕОТРЕСТ
Published: January 2025

Разжижение грунтов представляет собой критическую проблему в инженерной геологии и сейсмическом проектировании, так как оно может привести к значительным повреждениям сооружений и инфраструктуры.
Разжижение происходит, когда насыщенные водой несвязные грунты при сейсмических или других динамических воздействиях теряют свою прочность и переходят в полужидкое состояние. Это явление наблюдается чаще всего в районах с повышенной сейсмической активностью, но может проявляться и в других условиях. Одним из ключевых аспектов в изучении разжижения грунтов является моделирование поверхности разжижения, которое позволяет прогнозировать, при каких параметрах нагрузок и характеристиках грунтов начинается это явление. Для проведения такого моделирования используют различные параметры грунта, такие как относительная плотность, коэффициент пористости, коэффициент демпфирования, поровое давление и другие. Построение трехмерных графиков на основе этих параметров позволяет наглядно представлять поверхностные кривые разжижения и выявлять критические точки, при которых происходит потеря устойчивости грунтов. Цель данной работы заключается в разработке и анализе трехмерной модели поверхности разжижения грунтов на основе нескольких ключевых параметров грунтового массива, что позволит создать основу для прогнозирования разжижения и минимизации его последствий. Для анализа данных испытаний в компании АО МОСТДОРГЕОТРЕСТ была разработана специализированная система сбора и хранения данных, позволяющая проводить быстрый анализ архивных данных.. Для моделирования поверхности разжижения грунтов в данной работе использовался комплексный подход, основанный на численном анализе и визуализации данных.
The Role of Intention in Improving the Psychological Well-Being of Students: A Review with Islamic Approach
Authors:   Department of Administrative and Instructional Leadership, School of Education, St. John’s University, New York, Rahman Latifa
Published: January 2025

The study aims to explore intention's role in improving students' psychological well-being with an Islamic approach.
Psychological health has been the focus of intense research in recent years. Psychological well-being resides within the
individual's experience and is defined as feeling healthy and happy, having satisfaction, relaxation, pleasure, and peace of
mind. It deals with people's feelings about everyday experiences in life. The study discusses how the psychological wellbeing of the Islamic approach leads to a physically and psychologically healthy life and supportive behaviors such as less
use of harmful lifestyles, which improves individual psychological status as a student devoted to the Islamic approach for an
overall healthy life. The students and their academic achievements depend on psychological elements such as purpose, faith,
determination, focus, and confidence, which belong to the Islamic approach.
The Application of Business Intelligence in Human Resources in the 21st Century
Authors: Ahmed Boshra Khalifa
Published: January 2025

The management of human resources is one of the most critical aspects of any company's strategy, as it significantly influences the achievement of organizational goals. Modern human resource managers are increasingly utilizing advanced information technology tools and data analysis techniques to better understand the relationships between employees and organizational outcomes. This article explores the integration of Business Intelligence (BI) into the implementation of HR strategies, highlighting its benefits and the key performance indicators (KPIs) that enable the measurement and evaluation of these strategies. A systematic literature review methodology was employed, focusing on high-quality studies published in reputable journals and conferences indexed in databases such as ResearchGate and ScienceDirect. This rigorous approach ensured the inclusion of relevant and reliable research, providing a comprehensive synthesis of current knowledge and emerging themes in the application of BI in HR management. The findings aim to advance the theoretical and practical understanding of leveraging BI for strategic HR initiatives in the 21st century.
Self-Esteem, Self-Handicapping, and Social Desirability: A Mediational Analysis
Authors: Top Valentin , Fenouillet Fabien , Coudevylle Guillaume R.
Published: January 2025

This research investigates the mediational role of social desirability in the relationship between self-esteem and self-handicap. The aim is to understand the impact of the two dimensions of social desirability on the tendency to self-handicap. Using Baron and Kenny’s (1986) four-step procedure, 180 freshmen in sports science at the University of the French Antilles completed online surveys on self-esteem, social desirability, and self-handicap. Quantitative analysis shows that the self-deception dimension of social desirability is a partial mediator of this relationship, consistent with the idea that excuses and self-handicapping behaviors are not aligned with social norms.
The association of sexual dysfunction and male infertility: a literature review
Authors: Kakadiari Faidra , Potiris Anastasios , Drakaki Eirini , Mavrogianni Despoina , Karampitsakos Theodoros , Topis Spyridon , Domali Ekaterini , Drakakis Peter , Stavros Sofoklis
Published: January 2025

Introduction: Sexual dysfunction and male infertility are important issues concerning men’s health and reproductive potential. The relationship between these two conditions is complex and needs careful consideration. In this paper, we will look at how sexual dysfunction affects male fertility, looking at risk factors, why it happens, and ways to deal with it. This topic is important, as understanding it, can help improve men’s health and increase the chances of successful reproduction.

Purpose: The purpose of this paper is to examine the relationship between sexual dysfunction and male infertility. An effort is made to understand how sexual dysfunction affects men’s ability to reproduce, while examining risk factors, causes, and available treatment approaches.
Methodology: The methodology includes the analysis of the available literature, the collection and analysis of data from scientific studies, as well as the examination of the various methods of diagnosis and treatment of sexual dysfunction and male infertility.

Results: Analysis of the literature reveals significant associations between sexual dysfunction and male infertility. Scientific studies provide evidence of the causes and treatment options available.

Conclusions: Research papers on sexual dysfunction and male infertility reveal the importance of diagnosing and treating these problems for male health and reproductive capacity.
First live birth in Greece after blastocyst trophectoderm biopsy and preimplantation genetic testing for Holt-Oram Syndrome
Authors: Economou Konstantinos A. , Bili Chrysanthi , Florentin Lina , Thymis Fotios , Papanicolaou Dimitrios
Published: January 2025

Preimplantation genetic testing for monogenic/single-gene defects (PGT-M) is a well established tool in assisted reproduction. A couple, where the male was a carrier of the c.709C>T (p.Arg237Trp) pathogenic variant (autosomal dominant) of the exon 7 of TBX5 gene causing Holt-Oram syndrome (HOS) attended our clinic for PGT-M. The father and their first baby boy were both affected by HOS appearing syndactyly. Employing a strategy of preserving embryos after blastocyst trophectoderm biopsy by vitrification cryopreservation, we managed to screen 10 embryos collected from a single IVF cycle. Four embryos were found unaffected after preimplantation genetic analysis for the paternal pathogenic variant. The transfer of one normal blastocyst post-thaw resulted in a healthy and uneventful pregnancy and in the live birth of a male neonate on the 39th week of pregnancy. This is the first report of a live birth in Greece after blastocyst trophectoderm biopsy and preimplantation genetic analysis for Holt-Oram syndrome.
Intramyometrial ectopic pregnancy following in-vitro fertilization- a case report and review of literature
Authors: Nwogu Chidinma Magnus , Adefemi Ayodeji Kayode , Ugwu Aloy Okechukwu
Published: January 2025

Intramyometrial ectopic pregnancy is a very rare subset of ectopic pregnancy. It occurs when a pregnancy implants within the myometrium. The risk factors for this type of extrauterine pregnancy include previous history of uterine trauma such as myomectomy, caesarean section and dilatation and curettage. It can present with catastrophic outcome due to uterine rupture if undetected early. Prompt diagnosis allows for preservation of fertility. We present a 42-year-old lady with an intramyometrial ectopic pregnancy following an in-vitro fertilization and difficult embryo transfer who was managed successfully in our facility.
Self-Effacing Barbie: The Ideal, the Real and the Quest for Authentic Selfhood
Authors: Corrigan John Michael , Prystash Justin
Published: January 2025

This article argues that the immediate critical responses to the blockbuster film Barbie (Greta Gerwig, 2023), which diverged along ideological lines, fail to account for the extent to which the film undercuts the very ideological divisions that sustain them. Rather than or in addition to presenting a left-wing or right-wing critique of contemporary gender roles, the film positions this contest within the vexed relationship between the ideal and the real. This metaphysical quandary is what propels the protagonists on a Buddhist-inspired quest for authentic selfhood, a selfhood characterized by both the effacement of the discrete self (the Buddhist concept of anatman) and the eclipse of monumentalized cultural and commercial idols, like Barbie, that organize and disseminate ideology.
Kracauer and Tarkovsky’s Cinema of Redemptive Estrangement
Authors: Sullivan Daniel
Published: January 2025

Despite striking parallels between their philosophies and artistic work, there have been no prior dedicated studies of the reinforcing ideas of Siegfried Kracauer and Andrei Tarkovsky. I contend with other interpreters that Kracauer’s philosophy of film is best understood as a form of revelationism, with strong sociological and ontological theses about the nature of modern psychological life and the medium specificity of film. Essentially, Kracauer felt that certain films which adhere to what he called “truly cinematic” content by depicting the naturalistic “flow of life” have the potential to awaken in viewers a psychological reconnection to the concrete material world, in contrast to the experience of abstraction characteristic of modernity. Having presented Kracauer’s philosophy, I outline strong convergences in the philosophy and aesthetics of Tarkovsky, and illustrate these parallels through close analysis of Tarkovsky’s 1979 film Stalker. In the third section of this article, I further explore the converging revelationist philosophies of Kracauer–Tarkovsky by confronting them with critiques which were levied by Theodor Adorno (against Kracauer) and Fredric Jameson (against Tarkovsky). The reconstructed debate between these four critic/practitioners touches on central issues for film criticism, including methodological approaches of ontology versus dialectics and the question of how to represent utopic impulses in cinema.
Dureza superficial y resistencia a la compresión de materiales de restauración para dientes posteriores
Authors: Yanac - Acedo Lourdes Magdalena , Ríos – Caro Teresa Etelvina
Published: January 2025

Objective: To compare the in vitro surface hardness and compressive strength of three direct restorative materials for posterior teeth. Methodology: This is a cross-sectional comparative experimental in vitro study. The sample consisted of 60 cylinders divided into three groups of 20 samples: Tetric N-Ceram Bulk Fill resin, Alkasite Cention-N, and Giomer Beautifil II, which were prepared using a Teflon matrix that served as a mold to prepare cylinders with the restorative materials according to ISO 4049 standards. Surface hardness was measured using the Vickers hardness tester, while compressive strength was determined with the Universal Testing Machine, measured in Megapascals. Results: The obtained values for surface hardness showed that Beautifil II had the highest average with 66.36 Vickers, while Cention-N obtained 48.54 Vickers, and Tetric N-Ceram Bulk Fill 48.22 Vickers. Regarding compressive strength, the highest average was for Tetric N-Ceram Bulk Fill with 217.35 Megapascals, followed by Beautifil II with 195.83 Megapascals, and Cention-N with 187.55 Megapascals. Conclusion: Giomer Beautifil II presented the highest surface hardness, while Tetric N-Ceram Bulk Fill resin achieved the highest compressive strength. Conversely, Alkasite Cention-N obtained the lowest values for both mechanical properties.
Rehabilitación oral integral en paciente pediátrico de 6 años con alto riesgo de caries dental. Reporte de caso
Authors: Enríquez-Hidalgo Evelyn Viviana , Simbaña-Guerrero Nancy Sofía , Sacaquirín -Zhunio Pablo Cesar , Escobar-Hernández Brayan Santiago , Ortega-López Miriam Fernanda
Published: January 2025

Objective: To document and analyze the comprehensive oral rehabilitation process carried out in a 6-year-old pediatric patient at high cariogenic risk, using minimal intervention techniques to restore dental function and esthetics, improve general oral health and prevent future carious lesions. Case report: 6 year old male patient with no relevant medical-pathological history, with multiple carious lesions, a complete oral rehabilitation was performed, eight treatment sessions were carried out including prophylaxis, restoration with celluloid crowns, application of sealants and pulpotomy with Biodentine, resulting in the return of dental function and esthetics, the sealants prevented new carious lesions in the molars and when performing oral hygiene controls and plaque indexes showed significant improvement in the patient. Conclusion: Comprehensive oral rehabilitation using minimal intervention techniques such as sealants, plaque controls, celluloid crowns, showed good clinical performance in a 6-year-old pediatric patient with high risk of dental caries.
Asociación entre nivel de conocimiento de padres sobre salud bucal y caries dental en niños preescolares de tres colegios en Lima
Authors: Ramos Caballero Allison Brigitd , Sánchez Rodríguez Angie Melanie , Otazú Aldana Claudia Gabriela
Published: January 2025

Objetivo: Determinar la asociación entre nivel de conocimiento de salud bucal de padres de familia y caries dental con niños preescolares de tres colegios en Lima sur, Perú en el 2022. Materiales y Método: El diseño fue observacional y transversal. La muestra fue constituida por 120 padres y 120 niños de 3 a 5 años. Se realizó la evaluación clínica para registrar las lesiones de caries utilizando el índice ceod, y para el evaluar el nivel de conocimiento sobre salud bucal, se utilizó un cuestionario validado el cual fue aplicado a los padres de los niños. Se realizó el análisis descriptivo e inferencial de los datos y se utilizó la prueba del chi-cuadrado. Resultados: Los padres entre 30-37 años presentaron buen nivel de conocimiento (17.5%), la mayoría fue del sexo femenino (20.8%) y tuvo educación secundaria (18.3%). En una institución educativa pública, la mayoría de los niños presentó severidad de caries muy baja y tenían 4 años (17.5%), eran del sexo femenino (20%) y tenían padres con educación secundaria (20%). Se encontraron resultados similares en un colegio privado, variando los porcentajes relacionados a edad (3.3%), sexo (5.8%) y nivel de educación (5%). Por el contrario, en un colegio privado, la mayoría de los niños presentó severidad de caries muy baja y tenían 4 años (5.8%), eran del sexo masculino (8.3%) y sus padres tuvieron educación superior (10.8%). Estadísticamente se demostró que existe asociación significativa entre variables (p <0.05).
Asociación de la ansiedad materna y el comportamiento del niño durante la consulta odontopediátrica
Authors: Manrique Mamani Estefany Karen , Aguilar Gálvez Denisse Pilar
Published: January 2025

Objetivo: Determinar la asociación de la ansiedad materna y el comportamiento del niño en la consulta odontopediátrica. Materiales y Método: Estudio descriptivo de corte transversal. La muestra fue de 50 Madres e Hijos que acudieron a consulta odontopediátrica en La Clínica Odontológica de la Universidad Científica Del Sur. El nivel de ansiedad de la madre fue medido por medio de la escala de ansiedad dental de Corah modificada (SMDA) mediante un cuestionario que presentó un total de 5 preguntas, de las cuales tuvo opciones múltiples, para el comportamiento del niño Se utilizó la escala de Frankl. La madre firmó un consentimiento informado para el uso de estos instrumentos, se les detalló en qué consistía el estudio y posterior a ello todas las madres recibieron una charla de instrucción de higiene oral. Se utilizó la prueba Chi- cuadrado para el análisis estadístico de las variables. Resultados: La mayoría de las madres entre edades de 24 – 31 años presentó un nivel leve de ansiedad (34,0%). La mayor parte de los niños evaluados presentó un comportamiento definitivamente positivo (30,0%), predominando las niñas. Se encontró diferencia estadísticamente significativa, en referencia a la asociación de la ansiedad materna y el comportamiento del niño en la consulta odontopediátrica (p=0,032). Conclusiones: Existe asociación entre la ansiedad materna y el comportamiento del niño en la consulta odontopediátrica. El nivel de ansiedad materna fue leve en madres de 24 – 31 años, y el comportamiento de los niños de 6 a 8 años fue definitivamente positivo, principalmente en las niñas.
Fire Risk Management in Libraries: A Literature Review
Authors: Farras Nur Azizah  , Katrin Setio Devi
Published: January 2025

The purpose of this research is to describe the actions that can be taken by public libraries to prevent fires, as well as the factors that support and hinder these activities. This is a qualitative study using the literature review method, which involves collecting and analyzing literature as the source of data. A total of 10 articles were analyzed in this research. The fire prevention measures that can be taken by libraries are as follows: (1) regularly inspecting the building's condition, electrical systems, emergency exits, and the availability of fire extinguishing equipment; (2) storing flammable materials outside the main building; (3) implementing a no-smoking policy within the library premises; (4) turning off unnecessary electronic devices after closing hours; (5) establishing a fire disaster management committee; (6) creating a communication network and a list of contacts for fire disaster response services; (7) distributing firefighting equipment; (8) conducting training on fire disaster response procedures for all library staff. Factors that can support the preparedness of public libraries in dealing with fires are (1) an adequate number of fire-fighting equipment that is regularly inspected; (2) conducting training for staff on fire disaster response procedures by the local fire department; (3) the existence of fire response Standard Operating Procedures (SOP) that comply with safety standards and building conditions. On the other hand, factors hindering fire preparedness efforts in public libraries are (1) lack of knowledge about fires; (2) insufficient training to deal with fires; (3) staff indifference in taking preventive measures and preparations for fire disasters.
Analysis of Student Satisfaction Levels with Multimedia Services Sepuluh Nopember Institute of Technology (ITS) Library Using the Libqual+TM
Authors: Nyata Tondo Indra , Lolytasari Lolytasari
Published: January 2025

This study aims to analyze student satisfaction with multimedia services at the Sepuluh Nopember Institute of Technology (ITS) Library using the LibQUAL+TM indicator. LibQUAL+TM is a tool developed by the Association of Research Libraries (ARL) to assess user perceptions of library service quality. The research method used is quantitative with a survey approach. The research instrument was an online questionnaire developed based on three dimensions of LibQUAL+TM: the effect of service, information control, and Library as place. Data were collected from a sample of ITS students who used the Library's multimedia services in 2023. The analysis showed that overall, students were "Satisfied" with the effect of service but "Dissatisfied" with the dimensions of information control and the Library. Gap analysis shows that student perceptions have mostly exceeded minimum expectations but are still below ideal expectations. Some aspects that need to be improved are the completeness of the multimedia collection, ease of access, and facility updates and maintenance. This research provides valuable input for ITS library managers to improve the quality of multimedia services to meet student needs and expectations.
Studi Farmakovigilans Vaksinasi Booster Covid-19 Pada Masyarakat Di Desa Pujon Kalimantan Tengah
Authors: Norlita Devi , Yuwindry Iwan , Aryzki Saftia , Melviani Melviani
Published: January 2025

Latar belakang: Vaksinasi booster covid-19 diharapkan bisa mencapai terjadinya herd immunity (kekebalan kelompok) membentuk antibodi atau daya tahan tubuh yang kuat sehingga masyarakat bisa bertahan terhadap virus covid-19 dan harapan nya pandemi covid-19 berubah menjadi epidemi covid-19. Reaksi Obat Merugikan (ROM) efek samping yang tidak di inginkan dari suatu obat yang timbul pada pemberian obat dengan  dosis yang digunakan untuk profilaksis, diagnosis, dan terapi bersifat aktual atau potensial.Tujuan:  Mengetahui Studi Farmakovigilans vaksinasi booster covid-19 pada masyarakat Desa Pujon Kalimantan Tengah.Metode: Penelitian ini adalah Observasional bersifat Kuantitatif. dengan metode penelitian deskriptif, pendekatan yang digunakan dalam penelitian ini adalah cross sectional. Penelitian dilakukan pada bulan Juli di lingkungan Desa Pujon Kalimantan tengah.Hasil:  Dari efek samping vaksinasi booster covid-19 yaitu hasil pengukuran Algoritma Naranjo diketahui bahwa dari 98 jumlah responden, dari masyarakat desa pujon paling banyak mendapatkan hasil kategori hasil kategori Naranjo Probable (kemungkinan) merupakan efek samping vaksinasi covid-19 mendapatkan sebanyak 20 responden (20,41%). Diketahui terdapat sebanyak 55 responden mengalami efek samping kemungkinan terjadi. Diantaranya sebanyak 25 demam dan 30 nyeri setelah melakukan vaksinasi covid-19.Simpulan:  Dari efek samping vaksinasi booster covid-19 yaitu hasil pengukuran Algoritma Naranjo diketahui bahwa dari 98 jumlah responden, dari masyarakat desa pujon paling banyak mendapatkan hasil kategori hasil kategori Naranjo Possible merupakan kemungkinan efek samping vaksinasi covid-19 mendapatkan sebanyak 55 responden (56,12%). Diketahui terdapat sebanyak 55 responden mengalami kemungkinan efek samping pasti. Diantaranya sebanyak 25 responden mengalami demam dan 30 responden mengalami nyeri setelah melakukan vaksinasi covid-19
Penetapan Kadar Flavonoid Dan Aktivitas Antioksidan Ekstrak Etaanol Daun Bangkal (Nauclea subdita (Korth) Menggunakan Spektrofotometri Uv-Vis
Authors: Ulfah Annisa , Nastiti Kunti , Kurniawati Darini , Hakim Ali Rakhman
Published: January 2025

Latar belakang: Salah satu  Salah satu tanaman khas Kalimantan yang dapat dijadikan sebagai sumber pengobatan dan dapat dijadikan sebagai bahan herbal adalah Tanaman Bangkal. Pada bagian daunnya terdapat berbagai senyawa seperti alkaloid, steroid, tanin dan flavonoid. Senyawa yang mempunyai efek farmakologi kuat dan mempunyai peran sebagai antioksidan adalah senyawa flavonoid.Tujuan: Penelitian ini bertujuan untuk mengetahui kadar flavonoid dan aktivitas antioksidan ekstrak etanol Daun Bangkal (Nauclea subdita (Korth).Metode: Penelitian ini menggunakan metode ekstraksi menggunakan pelarut etanol 70% dan dilakukan perendaman selama 3 × 24 jam, ekstrak kental yang dihasilkan dilakukan uji kualitatif dengan identifikasi senyawa metabolit dan uji kuantitatif dengan penetapan kadar flavonoid serta aktivitas antioksidan.Hasil: Hasil identifikasi senyawa metabolit menggunakan pereaksi warna didapatkan ekstrak etanol Daun Bangkal (Nauclea subdita (Korth) mengandung senyawa alkaloid, steroid, tanin dan flavonoid. Kadar flavonoidnya sebesar 9,524 mgQE/g. Aktivitas antioksidan ekstrak etanol Daun Bangkal (Nauclea subdita (Korth) menunjukkan nilai IC50 sebesar 3,424 ppm.Simpulan: Ekstrak etanol Daun Bangkal (Nauclea subdita (Korth) mengandung senyawa alkaloid, steroid, tanin dan flavonoid. Kadar flavonoid sebesar 9,524 mgQE/g dan  aktivitas antioksidannya masuk dalam kategori sangat kuat
Penetapan Kadar Flavonoid Total Dan Aktivitas Antioksidan Daun Karinat (Rubus moluccanus L.)
Authors: Sadlia Fitri , Hakim Ali Rakhman , Saputri Rina , Rohama Rohama
Published: January 2025

Latar Belakang: Paparan lingkungan dapat memicu pembentukan radikal bebas yang disebut juga reactive oxygen spesies (ROS). Selain disebabkan faktor eksogen, radikal bebas juga dibentuk secara alamiah melalui metabolisme sel fisiologis. Radikal bebas yang tidak ditangani akan memberikan dampak negatif terhadap manusia, diantaranya terjadi perubahan abnormal yang mengenai gen tertentu dalam tubuh yang menyebabkan penyakit kanker. Salah satu senyawa kelompok metabolit sekunder yang memiliki potensi sebagai antioksidan adalah senyawa flavonoid. Ekstrak daun karinat juga terbukti secara kualitatif mengandung senyawa flavonoid berdasarkan hasil Kromatografi Lapis Tipis.Tujuan: Penelitian ini secara umum bertujuan mengetahui kadar total flavonoid dan aktivitas antioksidan pada ekstrak daun karinat (Rubus moluccanus L).Metode: Metode penelitian ini adalah eksperimental laboratorium dengan desain penelitian true-experimental dengan menggunakan rancangan post test only control group design. Kelompok kontrol dalam penelitian ini adalah kuersetin (DPPH) dan variasi konsentrasi ekstrak etanol daun karinat sebagai kelompok perlakuan.Hasil: Hasil penelitian menjelaskan bahwa ekstrak daun karinat memiliki kadar flavonoid total sebesar 143,8 mg/Qe/g dengan nilai rata-rata IC50 sebesar 1,32 ppm  yang berarti aktivitas antioksidan daun karinat sangat kuat dan lebih baik daripada kuersetin dengan nilai rata-rata IC50 2,19 ppm. Hasil analisis T-Independent Test diperoleh sebesar 0,000 yang berarti adanya perbedaan aktivitas antioksidan yang signifikan antara daun karinat dan kuersetin.Simpulan: Daun karinat memiliki aktivitas antioksidan yang sangat kuat sehingga daun karinat dapat dimanfaatkan sebagai antioksidan.
Penetapan Kadar Alkaloid Tanaman Kaluan (Vitex Pinnata L) dengan Tingkatan Fraksi
Authors: Ismiadi Rahmad , Rohama Rohama , Melviani Melviani , Mahdiyah Dede
Published: January 2025

Latar Belakang: Salah satu tumbuhan yang sering dimanfaatkan oleh masyarakat pedalaman Kalimantan Tengah yaitu tanaman kaluan atau halaban, yang mana tanaman kaluan atau halaban ini merupakan suatu tumbuhan khas kalimantan yang biasa orang dayak mengenalnya dengan laban. Tanaman kaluan sering dimanfaatkan oleh masyarakat sebagai pengobatan alami. Daun kaluan umumnya digunakan untuk obat luka, kudis, dan meredakan demam. Tanaman kaluan memiliki kandungan kimia, bagian daun dan kulit batang mengandung senyawa alkaloid, flavonoid, saponin, sterolterpenoid, dan tannin dengan jumlah relatif banyak, yang mana senyawa aktif dapat menangkal radikal bebas.Tujuan: Penelitian ini bertujuan untuk mengetahui kadar alkaloid pada tanaman kaluan (Vitex pinnata L) dengan tingkat fraksi, aquadest, kloroform, n-hexan.Metode: Penelitian ini menggunakan metode eksperimental dengan menggunakan jenis penelitian True Experimental yang bertujuan untuk melihat perbandingan kadar alkaloid dari ekstrak daun kaluan (Vitex pinnata Linn) pada penggunaan fraksi N-heksan, klorofom, dan metanol. Desain penelitian yang digunakan pada penelitian ini adalah Randomized block design (pengambilan sampel secara acak) dan membandingkan sampel dengan 3 fraksi yang digunakan (N-heksan, klorofom, dan aquadest).Hasil: Berdasarkan penelitian yang sudah dilakukan dapat disimpulkan bahwa kadar alkaloid total pada masing-masing yaitu, untuk fraksi n-heksan sebesar 8.03 %, untuk fraksi kloroform sebesar 7,1%, dan untuk fraksi aquadest sebesar 2,41%.Simpulan: Dari hasil penelitian dapat diketahui bahwa kadar alkaloid paling tinggi berada pada fraksi n-heksan, yaitu sebesar 8,03 %
Boris Innokentievich Lavrentiev (1892-1944): Essay on Life and Scientific Activity
Authors:   The Institute of Russian History of the Russian Academy of Sciences, Moscow, Russia, Tikhonov Vitaly V.
Published: January 2025

The article presents the biography of the medical scientist B. I. Lavrentiev,
based mainly on documents stored in the Archive of the Russian Academy
of Sciences, including those introduced into scientific circulation for the
first time. The article uses a biographical method that contributes to the
study of the scientist's life in a historical context and allows for a better
understanding of the processes and events that took place at that time.
B. I. Lavrentiev is known primarily as the creator of the national school of
neurohistology. His life fell during a dramatic period in the development of
the country and science, when revolutions and the civil war set the task of
preserving the scientific potential of the country for domestic medicine.
B.I. Lavrentiev became one of those who preserved pre-revolutionary
traditions for the Soviet era and stood at the origins of new directions of
its development. A world-renowned scientist, he did a lot to ensure that
Soviet medical science was not isolated.
Electrification of Saransk in the Pre-October Period Based on Documents of City Authorities
Authors:   Central State Archive of the Republic of Mordovia, Saransk, Russia, Kartashov Andrey V.
Published: January 2025

This article attempts to examine the history of the electrification of Saransk
in the pre-October period, reconstructed using archival documents. Key
points of this electrification show that initially, although at the initiative
of the city authorities, it was carried out by private entrepreneurs. Only
after the outbreak of World War I did the city power plant become the
property of the city.
Formation and Development of Sociological Science and Education in Saratov
Authors:   Saratov State University, Saratov, Russia, Pokatov Dmitry V.
Published: January 2025

In recent years, sociological science, despite a number of
constraining factors, continues to be one of the important components
of multifaceted social and humanitarian knowledge. The publications that
have appeared in recent years, dealing with various aspects, including
the history of the development of science and education itself, are mostly
devoted to the development of Russian sociology as a whole. Not a very
significant part of them touches upon the peculiarities of development
of sociological science and education in the regions. This fully applies to
such a typical region as the Saratov Oblast. Methods. These problems
are analyzed in the work on the basis of both general scientific methods
(deductive and inductive) and specific-problem methods, including genetic
and comparative-historical research approaches. Results and Discussion.
The history of the development of sociology in Saratov has quite a long
tradition. In the article, based on archival data, the author notes that we
can distinguish several stages in its development: the pre-sociological stage
(1918 — the mid-20s of the XX century), when the teaching of sociology
at Saratov State University just began; the revival stage (1990-2000); the
newest period - from the early 2000s to the present. If in the first period the
first tentative attempts to develop new scientific directions and approaches
and to lay the foundations for teaching a number of sociological disciplines (mainly on the basis of Saratov State University) are just beginning to appear,
then starting from the period of revival of sociological science the basic
directions of research are being outlined, including the history and theory
of sociology, economic and political sociology, methodology and methods
of sociological research. Conclusion. The processes of development of
sociological science and education, although somewhat separated in time,
at the same time constitute two mutually complementary vectors of the
multifaceted process of humanitarization of education in the region.
Review of the VCIOM B. A. Grushin Sociological Book Award
Authors:   Russian Research Institute of Economics, Politics and Law in Science and Technology (RIEPL), Moscow, Russia, Nikonov Vladimir A.
Published: January 2025

Introduction. The article gives a brief overview of the annual Grushin
Book Prize, awarded in several nominations on the occasion of the Day
of Sociologist in Russia. The author, without belittling the significance of
the presented works and the sociological potential of the researchers, has
reviewed individual works of laureates in some nominations. Methods. General
scientific methods of research were applied, in particular, the method of
synthesis and analysis. Results and Discussion. A retrospective chronology
of the Sociological Book Award competitions held for the period 2021-2024
is presented. The most interesting works are highlighted on the basis of
applied research, theoretical and popular science topics. Conclusion. Events
aimed at popularising science should be actively disseminated in the popular
science environment, as they allow not only to join the research community by
making oneself known. Staying in an atmosphere of live communication with
recognised scientific speakers, authors of papers, nominees and laureates
of various awards allows to exchange theoretical and practical knowledge
more quickly, to share experience, to hear the authoritative opinions of the
members of the expert council, in a word, to experience the real emotions of
inclusion in the process of scientific discourse.
From Past to Future: Filatov Museum of the History of Medicine
Authors:   National Medical Research Center of Endocrinology of the Ministry of Health of the Russian Federation, Moscow, Russia, Uzhanov Alexander E.
Published: January 2025

In the second part of the article, based on the documents of the State
Institute of Experimental Endocrinology of the People's Commissariat
of Health of the RSFSR 1925-1940, information on the chronology of the
development in our country of a specialized state medical institution in
the field of care for patients with disorders of the endocrine glands is
disclosed. Materials on the deployment of the industry in Soviet Russia for
the production and export of endocrine preparations from the endocrine
glands of animals, including domestic insulin for the treatment of diabetes
mellitus, are of considerable value. The efforts of the state, the medical
industry, and the State Institute of Experimental Endocrinology in the
fight against one of the ominous mass diseases in the RSFSR and the
USSR — endemic goiter, which in modern vocabulary is called iodine
deficiency diseases, are revealed. Of great scientific interest is the work
of the Insulin and Endocrine Committees and commissions established by
them, including the creation of standards in the production of domestic
insulin preparations, as well as the Goiter Commission under the Scientific
Medical Council of the People's Commissariat of Health on the organization of the first epidemiological expeditions to different regions of the country
to identify pathological iodine deficiency is of interest, which became an
important historical stage on the way to saving the nation from cretinism
and other thyroid diseases foci of goiter. The research conducted on the
territory of Kabardino-Balkaria on the introduction of the so-called Swiss
model for overcoming. Many aspects currently being implemented in
federal and regional programs for the prevention and treatment of iodine
deficiency diseases were first worked out in the 20-30s of the last century.
Early interception of Anterior crossbite using “Posterior Plan as Direct Tracts” in primary dentition: A simplified treatment approach
Authors: Shah Riddhika , Deshpande Anshula , KS Poonacha , Gaikwad Anuja
Published: January 2025

Anterior crossbite refers to ‘an abnormal labiolingual relationship between one or more maxillary and mandibular anterior teeth. Often found in primary and mixed dentition stages, early diagnosis and intervention are critical to prevent severe consequences such as attrition of anterior teeth, gingival recession, temporomandibular joint dysfunction, and restricted skeletal growth. Various removable and fixed appliances have been recommended for the correction. However, treatment outcomes depend on factors such as severity of crossbite, parental approval and patient co-operation. Younger pediatric patients require treatment strategies that are effective and independent of patient co-operation. This paper presents a simple and effective treatment approach for correction of anterior crossbite. We report a case of a 4-year-old patient, with a flat facial profile and anterior crossbite with retroclined maxillary deciduous incisors diagnosed as a pseudo class III malocclusion. Treatment was done using posterior Planas Direct Tracts (PDT) fabricated intraorally using High strength packable composite resin. (GC Solare X. GC India) Crossbite correction was seen within six weeks, resulting in a stable occlusion and improved maxillo-mandibular positioning. This method is highlighted for its simplicity, minimal patient compliance, and effectiveness in young children, offering an alternative to a more invasive or complex treatments. Present case report concludes that, PDT is an efficient and effective solution for the correction of early pseudo Class III malocclusion in primary dentitions.

Key Words
Anterior crossbite, Child, Malocclusion, Planas Direct Tracks
Occlusal characteristics, physiologic spaces and molar interproximal contacts in primary dentition of preschool children residing in North Maharashtra: A prospective observational study
Authors: Kulkarni Vinaya Kumar , Pawar Ganesh , Ahire Prajkta , Patil Amol , Musmade Deepti , Shelar Aishwarya
Published: January 2025

Occlusion in a growing child is considered as a dynamic rather than static relation between facial structures and also plays a significant role in determining occlusion in permanent dentition. The key prerequisite for the prevention of proximal caries is a contact area that prevents food impaction and facilitates easy plaque removal. The lack of data regarding the prevalence of these features led to the conduction of this study in the children of North Maharashtra. To determine the prevalence of occlusal characteristics, physiologic spaces and molar interproximal contacts in primary dentition of preschool children residing in North Maharashtra.

This survey was based on dental examinations of 728 children aged 3-5 years from North Maharashtra. Parental consent was obtained. All dental examinations were completed at the pre-schools. Children having all of their intact primary teeth were included, whereas children with premature loss of teeth or having dental caries were excluded from the study.

The flush terminal plane was the most common molar relationship followed by mesial step. Class-I canine relation was the most prevalent and spacing between the anterior teeth along with primate spaces were seen these children. The most common inter proximal molar contact type was I, followed by S, then O, and X.

This prevalence study clearly stated the presence of flush terminal plane, Class-I canine relationship, presence of primate spaces and I - shaped contact type in a pronounced fashion in the preschool children of North Maharashtra.

Key Words - Interproximal Contacts, OXIS, Preschool Children, Primary Dentition Prevalence
Comparison of the antibacterial effects of Nano silver containing mouthwash
with Chlorhexidine mouthwash in orthodontic patients
Authors: Pichai Saravanan , Peddu Revathi , Dokku Aruna , Lanka Devikanth , Talapaneni Ashok Kumar , Prasanna Kadiyala Lakshmi
Published: January 2025

Orthodontic treatment, using fixed appliances provides suitable conditions to bring about the colonization of cariogenic microorganisms. The oral pH levels and various microorganisms normally present in the oral cavity may influence the adhesion capacity of bacteria, a formation of biofilm, which increases the risk of demineralization in enamel, and caries development, particularly the bracket material. To prevent plaque formation both chlorhexidine and Nano silver mouth washes are used to reduce the colony forming units . The aim of the study was to compare the antimicrobial effect of Nano silver containing mouthwash with chlorhexidine mouthwash in orthodontic patient. Patients were randomly divided into two groups Group 1,patients using [0.2%]chlorhexidine mouth wash, group 2 patient using silver containing mouthwash[Nano life]. Between CFUs variables within the groups was calculated and the variation significance was calculated by mann whitney u test and Wilcoxon Signed Ranks Test. The results showed that the values of CFU decreased significantly (p 0.001] as the time of use nano silver mouth wash until reaching the highest value when the time of use was 4 weeks, that there was a definite reduction in the plaques in the CHX group from the 2nd week to the 4th week. Nano silver containing mouthwash had reduced the bacterial counts in orthodontic patients roughly in equal effect when compared with the gold standard Chlorhexidine mouth wash.

Key Words: chlorhexidine mouthwash, Nano silver, antimicrobial
Hybrid Ameloblastoma of Jaw-A Case Report
Authors: Ghosh Sudipa , S. Shivaprasad , L. Ashok , P. Shambulingappa
Published: January 2025

Odontogenic tumors of epithelial origin are common, and ameloblastoma is one of them. However, hybrid ameloblastoma' is infrequent and anomalous. Clinical, radiological, and histological characteristics of hybrid ameloblastoma can vary. Their biological composition remains controversial and they contain two or more distinct histological types. The patient, a 26-years-old man, complained of pain for 15 days and painless swelling in the area around his lower right back teeth for two months when he first visited the Department of Oral Medicine and Radiology. Diagnosed as Ameloblastoma with follicular and plexiform pattern, after clinical examination and biopsy. The lower right wisdom tooth was extracted as part of the enucleation procedure. The lesion area looked completely normal clinically after six months, with no signs of complications or recurrence.

Understanding this kind of ameloblastic variety whose histopathological presentation is varied-better is the goal, as it may present challenges for both diagnosis and treatment.

Key Words- Follicular, Hybrid ameloblastoma, Odontogenic, Plexiform
Resveratrol-loaded metal-organic framework for mitochondria-targeted amplified CO gas therapy
Authors: Wang Fengqin , Jiang Yinfang , Wang Yang
Published: January 2025

Carbon monoxide (CO) based gas therapy has recently garnered significant attention due to its remarkable therapeutic effects for various major diseases. However, the primary challenge in gas therapy is the effective delivery of gas prodrug to targeted sites, as well as achieving precise spatial-temporal control over their release behavior. In this work, we provide a facile method to design ROS-responsive and mitochondrial targeting CO-delivery nanoplatform, based on the thiol-functionalized metal-organic framework (MOF), abbreviated as UiO-66-SH, incorporating the drug resveratrol (RES) for combined tumor therapy. After endocytosis by tumor cells and localization within the mitochondria, UiO@FeCO@RES was decomposed by ATP to release RES and generate CO gas via a Fenton-like reaction between hydroxyl radicals (·OH) and FeCO. RES acts as an ATPase inhibitor, disrupting the metabolism of the respiratory chain in tumor cell and thereby facilitating ATP-blocked metabolic therapy. In vitro experimental results demonstrate that the combination therapy, involving both RES drug and CO gas therapy, exhibits a synergistic effect against cancer cells. This synergistic strategy has endowed UiO@FeCO@RES as a promising material for biomedical applications.