bluuebunny/crossref_metadata_2025 huggingface dataset:
Functional Overlay Model of Persistent Post-Concussion Syndrome
Authors: Mavroudis Ioannis , Chatzikonstantinou Simela , Petridis Foivos , Palade Octavian Dragos , Ciobica Alin , Balmus Ioana-Miruna
Published: July 2023

Persistent post-concussion syndrome (PPCS) is a complex and debilitating condition that can develop after head concussions or mild traumatic brain injury (mTBI). PPCS is characterized by a wide range of symptoms, including headaches, dizziness, fatigue, cognitive deficits, and emotional changes, that can persist for months or even years after the initial injury. Despite extensive research, the underlying mechanisms of PPCS are still poorly understood; furthermore, there are limited resources to predict PPCS development in mTBI patients and no established treatment. Similar to PPCS, the etiology and pathogenesis of functional neurological disorders (FNDs) are not clear neither fully described. Nonspecific multifactorial interactions that were also seen in PPCS have been identified as possible predispositions for FND onset and progression. Thus, we aimed to describe a functional overlay model of PPCS that emphasizes the interplay between functional and structural factors in the development and perpetuation of PPCS symptoms. Our model suggests that the initial brain injury triggers a cascade of physiological and psychological processes that disrupt the normal functioning of the brain leading to persistent symptoms. This disruption can be compounded by pre-existing factors, such as genetics, prior injury, and psychological distress, which can increase the vulnerability to PPCS. Moreover, specific interventions, such as cognitive behavioral therapy, neurofeedback, and physical exercise can target the PPCS treatment approach. Thus, the functional overlay model of PPCS provides a new framework for understanding the complex nature of this condition and for developing more effective treatments. By identifying and targeting specific functional factors that contribute to PPCS symptoms, clinicians and researchers can improve the diagnosis, management, and ultimately, outcomes of patients with this condition.
Nursing Graduates’ Preparedness for Practice: Substantiating the Call for Competency-Evaluated Nursing Education
Authors: McGarity Tammy , Monahan Laura , Acker Katelijne , Pollock Wendi
Published: July 2023

Practice readiness continues to be a challenge in healthcare. This was especially evident during the COVID-19 pandemic. This focused descriptive–correlational study examined nurses’ perceived preparedness for practice during the pandemic. One hundred and eighty-four registered nurses (RN) responded to Qualtrics survey questions addressing the competencies they perceived they had and the competencies they felt they needed that would have better prepared them to care for patients during the COVID-19 pandemic. The results demonstrated that although these nurses felt competent in certain areas, they perceived that they needed more education in those same areas to feel better prepared. Bivariate correlations and linear regression analysis indicated that institutional competency development, education, and work experience influenced perceived competency.
Investigating Latent Interactions between Students’ Affective Cognition and Learning Performance: Meta-Analysis of Affective and Cognitive Factors
Authors: Li Jian , Xue Eryong , Li Chenchang , He Yunshu
Published: July 2023

Affective and cognitive factors play significant roles in influencing students’ learning performance. However, limited studies exist that examine the latent interactions between these factors and students’ learning performance. This study applied a meta-analytic approach to examine the relationships between affective and cognitive factors and students’ learning performance through the selected publications. We identified 18 affective and cognitive influencing factors related to student learning achievement/performance. It was found that academic performance was significantly impacted by learning scores, future aspirations and goals, peer support for learning, and family support for learning. A moderate impact was observed for cognitive benefits, skill development, self-regulation, values, knowledge, character, self-belief, attitudes and beliefs, affective benefits, motivation, optimism, and behavioral engagement. A weak influence was observed for control and relevance of schoolwork and self-efficacy. The discussion and limitations of this study have also been provided in the last sections.
Casimir–Polder Force on Atoms or Nanoparticles from Gapped and Doped Graphene: Asymptotic Behavior at Large Separations
Authors: Klimchitskaya Galina L. , Mostepanenko Vladimir M.
Published: July 2023

The Casimir–Polder force acting on atoms and nanoparticles spaced at large separations from real graphene sheets possessing some energy gaps and chemical potentials is investigated in the framework of the Lifshitz theory. The reflection coefficients expressed via the polarization tensor of graphene, found based on the first principles of thermal quantum field theory, are used. It is shown that for graphene the separation distances, starting from which the zero-frequency term of the Lifshitz formula contributes more than 99% of the total Casimir–Polder force, are less than the standard thermal length. According to our results, however, the classical limit for graphene, where the force becomes independent of the Planck constant, may be reached at much larger separations than the limit of the large separations determined by the zero-frequency term of the Lifshitz formula, depending on the values of the energy gap and chemical potential. The analytic asymptotic expressions for the zero-frequency term of the Lifshitz formula at large separations are derived. These asymptotic expressions agree up to 1% with the results of numerical computations starting from some separation distances that increase with increasing energy gaps and decrease with increasing chemical potentials. The possible applications of the obtained results are discussed.
Evaluation and Optimization of Tour Method for Synthesis of Graphite Oxide with High Specific Surface Area
Authors: Bukovska Hanna , García-Perez Fernando , Brea Núñez Natalia , Bonales Laura J. , Velasco Andrés , Clavero M. Ángeles , Martínez Javier , Quejido Alberto J. , Rucandio Isabel , Gómez-Mancebo M. Belén
Published: July 2023

Many of the graphene-based structures exhibit an adsorption capacity due to their high specific surface area (SSA) and micropore volume. This capacity makes them competent materials for applications in energy and environmental sectors where efficiency is highly dependent on these properties for applications, such as water decontamination, solar cells or energy storage. The aim of this work is to study graphene-related materials (GRM) for applications where a high SSA is a requirement, considering the ideal SSA of graphene ≅ 2600 m2g−1. For the synthesis of most of the GRMs, some oxidation method such as the Tour method is used to oxidize graphite to graphite oxide (GrO) as an initial step. Our work studies the optimization of this initial step to evaluate the best conditions to obtain GrO with the maximum possible SSA. The different parameters influencing the process have been evaluated and optimized by applying an experimental design (ED). The resulting materials have been characterized by Brunauer–Emmett–Teller (BET), elemental analysis (EA), X-ray diffraction (XRD) and Raman and scanning electron microscopy (SEM). The evaluation of the results shows a maximum SSA of GrO of 67.04 m2g−1 for a temperature of 60 °C, a time of 12 h, a H2O2 volume of 50 mL and 4 g of KMnO4.
Understanding Sleep Disturbances in Prostate Cancer—A Scientometric Analysis of Sleep Assessment, Aetiology, and Its Impact on Quality of Life
Authors: Mangar Stephen , Abbadasari Monica , Carollo Alessandro , Esposito Gianluca , Ahmed Hashim , Shah Taimur , Dimitriou Dagmara
Published: July 2023

Prostate cancer is the most commonly diagnosed cancer in the United Kingdom. While androgen-deprivation therapy is the most common treatment for prostate cancer, patients undergoing this treatment typically experience side effects in terms of sleep disturbances. However, the relation between prostate cancer and sleep and the way in which sleep interventions may benefit oncological patients is underinvestigated in the literature. The current study aims to review in a data-driven approach the existing literature on the field of prostate cancer and sleep to identify impactful documents and major thematic domains. To do so, a sample of 1547 documents was downloaded from Scopus, and a document co-citation analysis was conducted on CiteSpace software. In the literature, 12 main research domains were identified as well as 26 impactful documents. Research domains were examined regarding the link between prostate cancer and sleep, by taking into account variations in hormonal levels. A major gap in the literature was identified in the lack of use of objective assessment of sleep quality in patients with prostate cancer.
GALNT1 Expression Is Associated with Angiogenesis and Is a Prognostic Biomarker for Breast Cancer in Adolescents and Young Adults (AYA)
Authors: Oshi Masanori , Ziazadeh Danya , Wu Rongrong , Chida Kohei , Yamada Akimitsu , Yamamoto Shinya , Narui Kazutaka , Yan Li , Ishikawa Takashi , Endo Itaru , Takabe Kazuaki
Published: July 2023

It is well established that genetic information differs amongst the adolescent and young adult population (AYA) and older patients. Although several studies on genetic information have been conducted, no current prognostic biomarker exists to help differentiate survival outcomes amongst AYA patients. The GALNT family of genes have been associated with several cancer etiologies, such as the Tn antigen and epithelial-mesenchymal transition (EMT); however, the clinical significance of GALNT1 expression in breast cancer (BC) remains unclear. We investigated the clinical relevance of GALNT1 expression in BC using two large independent cohorts. We found that, although triple-negative BC (TNBC) had the highest GALNT1 expression compared to ER-positive/HER2-negative BC, GALNT1 levels in BC were not associated with clinical aggressiveness, including histological grade, AJCC stage and N-category, and patient survival, consistently in both the METABRIC and GSE96058 cohorts. There was also no biological difference between low- and high-GALNT1 expression BC, as analyzed by hallmark gene sets via gene set enrichment analysis (GSEA). Further, no significant difference was found in GALNT1 expression levels among AYAs and older patients. However, high GALNT1 expression was associated with significantly worse survival in AYA patients, in both cohorts. Furthermore, high GALNT1 expression was found to be an independent factor among several clinical features, including subtype, histological grade, AJCC T and N-category, in AYA patients. In both cohorts, BC with high GALNT1 expression demonstrated low levels of CD8+ T-cell infiltration, but not other anti-cancerous or pro-cancerous immune cells. Finally, high levels of GALNT1 BC demonstrated increased EMT, angiogenesis, and protein secretion in the AYA population, but not in older patients. In conclusion, our findings demonstrate that GALNT1 expression was found to be associated with angiogenesis and EMT, and may have potential as prognostic biomarker, specifically in AYA patients.
The Effectiveness of Cancer Immune Checkpoint Inhibitor Retreatment and Rechallenge—A Systematic Review
Authors: Perdyan Adrian , Sobocki Bartosz Kamil , Balihodzic Amar , Dąbrowska Anna , Kacperczyk Justyna , Rutkowski Jacek
Published: July 2023

Despite a great success of immunotherapy in cancer treatment, a great number of patients will become resistant. This review summarizes recent reports on immune checkpoint inhibitor retreatment or rechallenge in order to overcome primary resistance. The systematic review was performed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The search was performed using PubMed, Web of Science and Scopus. In total, 31 articles were included with a total of 812 patients. There were 16 retreatment studies and 13 rechallenge studies. We identified 15 studies in which at least one parameter (overall response rate or disease control rate) improved or was stable at secondary treatment. Interval treatment, primary response to and the cause of cessation for the first immune checkpoint inhibitors seem to be promising predictors of secondary response. However, high heterogeneity of investigated cohorts and lack of reporting guidelines are limiting factors for current in-depth analysis.
Relevance of Endoscopic Ultrasound in Endocrinology Today: Multiple Endocrine Neoplasia Type 1, Insulinoma, Primary Aldosteronism—An Expert’s Perspective Based on Three Decades of Scientific and Clinical Experience
Authors: Kann Peter Herbert
Published: July 2023

In endocrinology, endoscopic ultrasound (EUS) may be used to image the adrenals, the endocrine pancreas, and other organs where endocrine neoplasms may occur. During the recent decades, EUS has been established predominantly to assess multiple endocrine neoplasia type 1, to localize insulinomas, and to identify aldosterone-producing adenomas. EUS in endocrinology requires special skills and individual experience in order to provide reliable diagnostic information.
Emotional, Behavioral, and Physical Health Consequences in Caregivers of Children with Cancer: A Network Analysis Differentiation in Mothers’ and Fathers’ Reactivity
Authors: Scarponi Dorella , Sarti Pierfrancesco , Rivi Veronica , Colliva Chiara , Marconi Elisa , Pession Andrea , Blom Johanna M. C.
Published: July 2023

Background: Pediatric cancer presents mental and physical challenges for patients and their caregivers. However, parental distress has been understudied despite its negative impact on quality of life, disability, and somatic disorders. Parents of oncopediatric patients experience high levels of suffering with their resilience tested throughout their children’s illness. Identifying at-risk parents and offering specific treatments is crucial and urgent to prevent or alleviate negative outcomes. Methods: This study used statistical and network analyses to examine symptom patterns assessed by the Kellner Symptom Questionnaire in 16 fathers and 23 mothers at different time points: diagnosis, treatment, and discharge. Results: The results indicated significantly higher distress levels in parents of oncopediatric children compared to the control reference population. Gender-specific differences in symptom profiles were observed at each time point, and symptoms showed a gradual but non-significant decrease over time. Conclusions: The network analysis yielded valuable insights that, when applied in clinical practice, can guide the implementation of timely treatments to prevent and manage parental distress, thus addressing long-term, stress-related issues in primary caregivers of children diagnosed and treated for cancer.
Melanoma Cells Inhibit iNKT Cell Functions via PGE2 and IDO1
Authors: Torre Enza , Pinton Giulia , Lombardi Grazia , Fallarini Silvia
Published: July 2023

Invariant natural killer T (iNKT) cells are a distinct group of immune cells known for their immunoregulatory and cytotoxic activities, which are crucial in immune surveillance against tumors. They have been extensively investigated as a potential target for adoptive cell immunotherapy. Despite the initial promise of iNKT cell-based immunotherapy as a treatment for melanoma patients, its effective utilization has unfortunately yielded inconsistent outcomes. The primary cause of this failure is the immunosuppressive tumor microenvironment (TME). In this study, we specifically directed our attention towards melanoma cells, as their roles within the TME remain partially understood and require further elucidation. Methods: We conducted co-culture experiments involving melanoma cell lines and iNKT cells. Results: We demonstrated that melanoma cell lines had a significant impact on the proliferation and functions of iNKT cells. Our findings revealed that co-culture with melanoma cell lines led to a significant impairment in the expression of the NKG2D receptor and cytolytic granules in iNKT cells. Moreover, we observed a strong impairment of their cytotoxic capability induced by the presence of melanoma cells. Furthermore, through the use of selective inhibitors targeting IDO1 and COX-2, we successfully demonstrated that the melanoma cell line’s ability to impair iNKT cell activation and functions was attributed to the up-regulation of IDO1 expression and PGE2 production.
Double Guard Efficiency and Safety—Overcoming Resistance to Immunotherapy by Blocking or Stimulating Several Immune Checkpoints in Non-Small Cell Lung Cancer Patients
Authors: Kalinka Ewa , Wojas-Krawczyk Kamila , Krawczyk Paweł
Published: July 2023

Immunotherapy is one of the leading systemic therapies in non-small cell cancer (NSCLC) patients, but it is not effective in an important proportion of them due to primary or secondary resistance mechanisms. Clinicians do not have the tools to predict immunotherapy resistance, and thus, many patients still fail initial treatment. One of the scientific concepts to avoid resistance and/or offer the patient effective salvage second-line treatment is the dual immunologic checkpoint blockade. We aimed to review published and available data on combination immunotherapy in terms of mechanisms, efficacy, and safety data on many different dual blockades. We discussed the potential of combined CTLA-4 (Cytotoxic T Lymphocyte Antigen 4), PD-1 (Programmed Death 1) or PD-L1, TIGIT, LAG-3, TIM-3, macrophage leukocyte immunoglobulin-like receptor B2 (LILRB2/ILT4), S15-mediated immune suppression (SIGLEC-15), CD137, ICOS, and OX40 inhibitors in NSCLC treatment.
Mesenchymal Stem Cells Delivered Locally to Ischemia-Reperfused Kidneys via Injectable Hyaluronic Acid Hydrogels Decrease Extracellular Matrix Remodeling 1 Month after Injury in Male Mice
Authors: Han Daniel S. , Erickson Christopher , Hansen Kirk C. , Kirkbride-Romeo Lara , He Zhibin , Rodell Christopher B. , Soranno Danielle E.
Published: July 2023

The translation of stem cell therapies has been hindered by low cell survival and retention rates. Injectable hydrogels enable the site-specific delivery of therapeutic cargo, including cells, to overcome these challenges. We hypothesized that delivery of mesenchymal stem cells (MSC) via shear-thinning and injectable hyaluronic acid (HA) hydrogels would mitigate renal damage following ischemia-reperfusion acute kidney injury. Acute kidney injury (AKI) was induced in mice by bilateral or unilateral ischemia-reperfusion kidney injury. Three days later, mice were treated with MSCs either suspended in media injected intravenously via the tail vein, or injected under the capsule of the left kidney, or MSCs suspended in HA injected under the capsule of the left kidney. Serial measurements of serum and urine biomarkers of renal function and injury, as well as transcutaneous glomerular filtration rate (tGFR) were performed. In vivo optical imaging showed that MSCs localized to both kidneys in a sustained manner after bilateral ischemia and remained within the ipsilateral treated kidney after unilateral ischemic AKI. One month after injury, MSC/HA treatment significantly reduced urinary NGAL compared to controls; it did not significantly reduce markers of fibrosis compared to untreated controls. An analysis of kidney proteomes revealed decreased extracellular matrix remodeling and high overlap with sham proteomes in MSC/HA-treated animals. Hydrogel-assisted MSC delivery shows promise as a therapeutic treatment following acute kidney injury.
Interaction of Interleukin-17A with a Th2 Response in a Mouse Model of Allergic Airway Inflammation
Authors: Peters Karin , Ernst Stefanie , Peters Marcus
Published: July 2023

Background: A total of 262 million people worldwide suffer from asthma and 461000 people died from it in 2019. Asthma is a disease with different endotypes defined by the granulocytes found in the asthmatic lung. In allergic asthma, the eosinophilic endotype is present, driven by a TH2 response. A TH17 immune response leads to the neutrophil endotype. This often causes uncontrolled asthma and is triggered by pollutants, microbes, and oxidative stress. It has been described that a significant number of patients with eosinophilic asthma develop mixed granulocytic asthma over time. The severity of asthma in the mixed endotype is related to the proportion of neutrophils in the lungs. Purpose: In this report, we address the question of how a TH2 response interacts with IL-17A in allergic asthma. Methods: To this end, we used a mouse model to induce allergic asthma followed by an aerosol challenge with ovalbumin. To investigate the role of IL-17A, we administered IL-17A intranasally during the challenge phase. Results: IL-17A alone did not elicit an immune response, whereas in combination with allergic asthma, it resulted in a shift of the asthmatic endotype from eosinophilic to neutrophilic. TGFβ1 was increased in these lungs compared to asthmatic lungs without IL-17A, as was the expression of the IL-17A receptor subunits IL-17RA and IL-17RC. In cultures with human cells, we also found that IL-17A increased the expression of its receptors only in combination with IL-13. We also found this effect for IL-8, which attracts neutrophils in humans. Conclusions: The TH2 response increased the sensitivity to IL-17A in a mouse asthma model as well as in human cell lines.
C-Reactive Protein Level and the Genetic Variant rs1130864 in the CRP Gene as Prognostic Factors for 10-Year Cardiovascular Outcome
Authors: Schulz Susanne , Rehm Selina , Schlitt Axel , Lierath Madlen , Lüdike Henriette , Hofmann Britt , Bitter Kerstin , Reichert Stefan
Published: July 2023

Background: Cardiovascular disease (CVD) is the primary cause of premature death and disability worldwide. There is extensive evidence that inflammation represents an important pathogenetic mechanism in the development and prognosis of CVD. C-reactive protein (CRP) is a potential marker of vascular inflammation and plays a direct role in CVD by promoting vascular inflammation. The objective of this study (ClinTrials.gov identifier: NCT01045070) was to assess the prognostic impact of CRP protein levels and genetic variants of CRP gene events on cardiovascular (CV) outcome (10-year follow-up) in patients suffering from CVD. Methods: CVD patients were prospectively included in this study (n = 1002) and followed up (10 years) regarding combined CV endpoint (CV death, death from stroke, myocardial infarction (MI), and stroke/transient ischemic attack (TIA)). CRP protein level (particle-enhanced immunological turbidity test) and genetic variants (rs1130864, rs1417938, rs1800947, rs3093077; polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) after DNA extraction from EDTA-blood) were evaluated. Results: In survival analyses, increased CRP protein levels of ≥5 mg/L (log-rank test: p < 0.001, Cox regression: p = 0.002, hazard ratio = 1.49) and CT + TT genotype of rs1130864 (log-rank test: p = 0.041; Cox regression: p = 0.103, hazard ratio = 1.21) were associated with a weaker CV prognosis considering combined CV endpoint. Conclusions: Elevated CRP level and genetic variant (rs1130864) were proven to provide prognostic value for adverse outcome in CVD patients within the 10-year follow-up period.
Pattern Distribution of Connexins in the Ortho- and Parakeratinized Epithelium of the Lingual Mucosa in Birds
Authors: Skieresz-Szewczyk Kinga , Jackowiak Hanna
Published: July 2023

Connexins are important proteins involved in cell-to-cell communication and cytodifferentiation during renewal and cornification of the multilayered epithelia. So far, there is a lack of reports on this subject in birds’ structurally different ortho- and parakeratinized epithelium of the tongue. The study aims to describe the distribution and expression profiles of the α-connexins (Cx40 and 43) and β-connexins (Cx26, 30, and 31) in those epithelia in duck, goose, and domestic turkey. Research revealed the presence of the mentioned connexins and the occurrence of interspecies differences. Connexins form gap junctions in the cell membrane or are in the cytoplasm of keratinocytes. Differences in connexin expression were noted between the basal and intermediate layers, which may determine the proliferation of keratinocytes. Cx40, 43, and Cx30 in the gap junction of the keratinocytes of the intermediate layer are related to the synchronization of the cornification process. Because of the exfoliation of cornified plaques, a lack of connexins was observed in the cornified layer of orthokeratinized epithelium. However, in parakeratinized epithelium, connexins were present in the cell membrane of keratinocytes and thus maintained cellular integrity in gradually desquamating cells. The current studies will be useful in further comparative analyses of normal and pathological epithelia of the oral cavity in birds.
Influence of Cr Nanoparticles on Plasma Electrolytic Oxidation Coatings on AM50 Mg Alloy
Authors: Lv Wenze , Lu Xiaopeng , Chen Qianqian , Ma Jirui , Karpushenkov Sergey A. , Ignatenko Oleg V. , Wang Fuhui
Published: July 2023

The addition of Cr nanoparticles to a plasma electrolytic oxidation (PEO) electrolyte offers the possibility of producing layers with a broader range of coating compositions and improved properties. In this study, the effects of nanoparticles and various voltages on coating formation, microscopic morphology, and phase composition were investigated with in situ incorporation of Cr nanoparticles into PEO-coated Mg alloy. The results show that the corrosion performance of the coating was significantly improved when the final voltage was set to 460 V and the concentration of Cr nanoparticles was 1 g/L. Compared to the particle-free coating, the corrosion current density of the coating with the addition of 1 g/L Cr nanoparticles was reduced by two orders of magnitude. The impedance at the low frequency (0.01 Hz) increased by more than one order of magnitude after one hour of immersion, indicating a considerable improvement in corrosion resistance. Due to the high temperature during the coating-formation process, the Cr nanoparticles were oxidized, resulting in the formation of Cr2O3. The existence of Cr2O3 slightly increased the growth rate of the coating and sealed the open pores of the coating.
Epoxy Coating Modification with Metal Nanoparticles to Improve the Anticorrosion, Migration, and Antibacterial Properties
Authors: Samardžija Marina , Stojanović Ivan , Vuković Domanovac Marija , Alar Vesna
Published: July 2023

Nanoparticles are capable of making more durable and stronger materials with better chemical resistance. They are used for a wide range of applications. Likewise, the potential of metal nanoparticles as antimicrobial agents has been widely studied. In this work, we investigate various nanoparticles (Al, Ni, Ag) incorporated into epoxy coating. The anticorrosion and antibacterial properties of the unmodified and modified coatings were evaluated. According to the SEM and EDS analyses, the coating did not contain agglomerates, which confirms the quality of the dispersion of inorganic nanoparticles in the coating. After 24 h and 10days immersions in a 3.5 wt.% NaCl solution, the corrosion behaviour for all nanocomposite was studied by means of EIS investigations. The study included the evaluation of the inhibition zone of the nanoparticles and the antimicrobial properties of the nanocomposite. It was found that the nanoparticles of Al and Ag provide excellent antibacterial properties. The epoxy nanocomposite with Al NP showed the migration of ions in the range from 0.75 to 1 mg/L in a wastewater solution for 30 days, indicating a potential for antimicrobe activity. The 1% Al NP epoxy nanocomposite showed good anticorrosion and antibacterial properties and demonstrated great potential for applications in pipelines.
Applications of Modified Bessel Polynomials to Solve a Nonlinear Chaotic Fractional-Order System in the Financial Market: Domain-Splitting Collocation Techniques
Authors: Izadi Mohammad , Srivastava Hari Mohan
Published: July 2023

We propose two accurate and efficient spectral collocation techniques based on a (novel) domain-splitting strategy to handle a nonlinear fractional system consisting of three ODEs arising in financial modeling and with chaotic behavior. One of the major numerical difficulties in designing traditional spectral methods is in the handling of model problems on a long computational domain, which usually yields to loss of accuracy. One remedy is to split the underlying domain and apply the spectral method locally in each subdomain rather than on the global domain of interest. To treat the chaotic financial system numerically, we use the generalized version of modified Bessel polynomials (GMBPs) in the collocation matrix approaches along with the domain-splitting strategy. Whereas the first matrix collocation scheme is directly applied to the financial model problem, the second one is a combination of the quasilinearization method and the direct first numerical matrix method. In the former approach, we arrive at nonlinear algebraic matrix equations while the resulting systems are linear in the latter method and can be solved more efficiently. A convergence theorem related to GMBPs is proved and an upper bound for the error is derived. Several simulation outcomes are provided to show the utility and applicability of the presented matrix collocation procedures.
Synergistic Effect in Ionizing Radiation Shielding with Recent Tile Composites Blended with Marble Dust and BaO Micro/Nanoparticles
Authors: Aloraini Dalal A. , Elsafi Mohamed , Almuqrin Aljawhara H. , Yasmin Sabina , Sayyed M. I.
Published: July 2023

In this study, we investigated the impact of micro- and nano-sized barium oxide addition on the radiation-shielding properties of red clay tiles mixed with waste marble and different sizes of BaO (micro- or nanoparticles) for comparative analysis. The linear attenuation coefficients (LAC) of the prepared samples were measured using an HPGe detector between 0.060 and 1.333 MeV. Moreover, a comparison was made between the experimental micro-composites and values obtained by Phy-X software. The results revealed that the red clay/waste marble tile composites doped with nano-sized BaO demonstrated superior radiation-shielding properties compared to those doped with micro-sized BaO. At 1.33 MeV, WR-20mBaO (containing 20 wt % micro-sized BaO) and WR-20nBaO (containing 20 wt % nano-sized BaO) exhibited HVL values of 4.75 cm and 4.25 cm, respectively. The lower HVL value of WR-20nBaO indicates superior radiation-shielding performance, highlighting the potential benefits of using nano-sized BaO as a radiation-shielding additive. Our findings also demonstrated that increasing the amount of BaO deposited onto red clay mixed-waste marble resulted in improved radiation-shielding properties. Our study demonstrates that adjusting the concentration of BaO is a viable strategy for enhancing the radiation attenuation properties of red clay tiles. In addition, the addition of waste marble to the tiles enhances its mechanical properties, and it is also positively recycled in community service.
Preventive Epigenetic Mechanisms of Functional Foods for Type 2 Diabetes
Authors: Abubakar Bilyaminu , Usman Dawoud , Sanusi Kamaldeen Olalekan , Azmi Nur Hanisah , Imam Mustapha Umar
Published: July 2023

Type 2 diabetes (T2D) is a growing global health problem that requires new and effective prevention and management strategies. Recent research has highlighted the role of epigenetic changes in the development and progression of T2D, and the potential of functional foods as a complementary therapy for the disease. This review aims to provide an overview of the current state of knowledge on the preventive epigenetic mechanisms of functional foods in T2D. We provide background information on T2D and its current treatment approaches, an explanation of the concept of epigenetics, and an overview of the different functional foods with demonstrated preventive epigenetic effects in T2D. We also discuss the epigenetic mechanisms by which these functional foods prevent or manage T2D, and the studies that have investigated their preventive epigenetic effects. In addition, we revisit works on the beneficial influence of functional foods against the programming and complications of parentally-triggered offspring diabetes. We also suggest, albeit based on scarce data, that epigenetic inheritance mechanistically mediates the impacts of functional nutrition against the metabolic risk of diabetes in offspring. Finally, our review highlights the importance of considering the preventive epigenetic mechanisms of functional foods as a potential avenue for the development of new prevention and management strategies for T2D.
Day-Ahead Electricity Price Probabilistic Forecasting Based on SHAP Feature Selection and LSTNet Quantile Regression
Authors: Liu Huixin , Shen Xiaodong , Tang Xisheng , Liu Junyong
Published: July 2023

Electricity prices are a central element of the electricity market, and accurate electricity price forecasting is critical for market participants. However, in the context of increasingly integrated economic markets, the complexity of the electricity system has increased. As a result, the number of factors required to consider in electricity price forecasting is growing. In addition, the high percentage of renewable energy penetration has increased the volatility of electricity generation, making it more challenging to predict prices accurately. In this paper, we propose a probabilistic forecasting method based on SHAP (SHapley Additive exPlanation) feature selection and LSTNet (long- and short-term time-series network) quantile regression. First, to reduce feature redundancy and overfitting, we use the SHAP method to perform feature selection in a high-dimensional input feature set, and specifically analyze the magnitude and manner in which features affect electricity prices. Second, we apply the LSTNet quantile regression model to predict the electricity value under different quantiles. Finally, the probability density function and the prediction interval of the predicted electricity prices are obtained by kernel density estimation. The case of the Danish electricity market validates the effectiveness and accuracy of our proposed method. The accuracy of the proposed method is better than that of other methods, and we assess the importance and direction of the impact of features on electricity prices.
Experimental Study of the Influence of the Geometrical Parameters of the Radial Labyrinth Pump on the Pump’s Operating Parameters and Performance
Authors: Szulc Przemysław , Skrzypacz Janusz , Lorenz Witold
Published: July 2023

Centrifugal pumps are the most common machines responsible for the increase in hydraulic energy in a piping system. Their proper design, operation, and maintenance have a strong influence on the performance of technological processes carried out in many industrial units. For the ultra-low specific speed (nq < 10) application, there is no economical reason for these pumps to be used. This is caused by an increase in internal losses in the pump. The article concerns the problem of the hydraulic operation of a new type of labyrinth pump—the radial labyrinth pump (RLP), which is a developed axial unit. The main research method involves the experimental research of hydraulic sets consisting of passive and active discs. The analyses were preceded by dimensional analysis and experimental planning. The study investigates the influence of a chosen structural parameter of both discs on the process of energy conversion obtained in the pump. The influence of parameters such as number, depth and width of the grooves, as well as inlet angle and diameter on the properties of the pump was studied and discussed in detail. The essential novelty of the article is the recognition of the hydraulic performance of the RLP with grooved discs. To extend the scope of the conducted research for the chosen hydraulic sets, a comparison of the mutual cooperation of an active disc with a smooth and grooved passive one was conducted. It was identified that not every geometric relationship of the parameters of the active and passive discs results in an increase in head with respect to cooperation with a smooth passive disc (motionless). The highest head and high efficiencies were obtained for sets with short channels with large inlet diameters—zk12 and zk13—ratios for zk12 d1ap/d2ap = 0.78, and for zk13 zk12 d1ap/d2ap = 0.81. Based on the obtained results, preliminary recommendations for the construction were made.
Optimized Circulating Current Control and Enhanced AC Fault Ride-through Capability Using Model Predictive Control for MMC-HVDC Applications
Authors: Soomro Jahangeer Badar , Chachar Faheem Akhtar , Shah Madad Ali , Memon Abdul Aziz , Alsaif Faisal , Alsulamy Sager
Published: July 2023

This paper presents a novel model predictive control (MPC) approach for suppressing circulating currents in MMC-based HVDC systems. The proposed MPC eliminates the need for PI-regulators and pulse width modulators, resulting in improved dynamic response and controllability. The methodology demonstrates exceptional efficacy in controlling output current and addressing voltage ripple concerns associated with sub module (SM) capacitors. An innovative, communication-free fault ride-through (FRT) method is also introduced, eliminating the need for a DC chopper and ensuring rapid recovery following faults. To overcome the computational challenges associated with the traditional MPC algorithm, an aggregate model of the MMC is proposed, significantly reducing predicted states, hardware requirements, and calculations. Simulations validate the robustness of the proposed MPC control algorithm in tracking AC side current, suppressing circulating current, and regulating capacitor voltages under various scenarios. Future research will explore system expansion, integration with renewable energy sources, and hardware-in-loop setup testing for further validation.
Improved High Temperature Thermoelectric Properties in Misfit Ca3Co4O9 by Thermal Annealing
Authors: Chatterjee Arindom , El Sachat Alexandros , Banik Ananya , Biswas Kanishka , Castro-Alvarez Alejandro , Sotomayor Torres Clivia M. , Santiso José , Chávez-Ángel Emigdio
Published: July 2023

Ca3Co4O9, a p-type thermoelectric material based on transition-metal oxides, has garnered significant interest due to its potential in thermoelectric applications. Its unique misfit-layered crystal structure contributes to low thermal conductivity and a high Seebeck coefficient, leading to a thermoelectric figure of merit (zT) of ≥1 at 1000 K. Conventionally, it has been believed that thermopower reaches its upper limit above 200 K. However, our thermopower measurements on polycrystalline Ca3Co4O9 samples have revealed an unexpected increase in thermopower above 380 K. In this study, we investigate the effects of high oxygen pressure annealing on Ca3Co4O9 and provide an explanation based on the mixed oxide states of cobalt and carrier hopping. Our results demonstrate that annealing induces modifications in the defect chemistry of Ca3Co4O9, leading to a decrease in electron hopping probability and the emergence of a thermal activation-like behavior in thermopower. These findings carry significant implications for the design and optimization of thermoelectric materials based on misfit cobaltates, opening new avenues for enhanced thermoelectric performance.
Experimental and Numerical Analysis of Wooden Sonic Crystals Applied as Noise Barriers
Authors: D’Orazio Tommaso , Asdrubali Francesco , Godinho Luís , Veloso Matheus , Amado-Mendes Paulo
Published: July 2023

Recent research has been developed by different groups towards the development of sonic crystals as noise barriers. The present paper aims to contribute to this research, focusing on the possible application of this technology in practice, and exploring some aspects that may be useful for its further development. One of the objectives of this work is to explore the differences between experimental results obtained under laboratory conditions and numerical results computed with the finite element method (FEM), in 2D and 3D, understanding if different types of simplified models can be of use in the practical analysis of sonic crystals. Through this comparison, a validation of the prediction numerical models is performed, giving confidence for their use in the development and study of sonic crystal configurations. In this context, different geometric arrangements of the sonic crystals’ scatterers (the individual elements that make up the barriers) have been analyzed with the help of the numerical method, evaluating their behavior in different arrangements of numbers of elements, shape and size. A number of parametric studies are also performed introducing some randomness in the structure (in scatterer size and spacing), and analyzing its effect on the insertion loss provided by the sonic crystal. These contributions can be significantly useful for the development of new solutions, giving important hints about the sensitivity of these structures to possible defects or limitations in their production.
Forest Fire Spread Simulation and Fire Extinguishing Visualization Research
Authors: Meng Qingkuo , Lu Hao , Huai Yongjian , Xu Haifeng , Yang Siyu
Published: July 2023

There are three main types of forest fires: surface fires, tree crown fires, and underground fires. The frequency of surface fires and tree crown fires accounts for more than 90% of the overall frequency of forest fires. In order to construct an immersive three-dimensional visualization simulation of forest fires, various forest fire ignition methods, forest fire spread, and fire extinguishing simulation exercises are studied. This paper proposes a lightweight forest fire spread method based on cellular automata applied to the virtual 3D world. By building a plant model library using cells to express different plants, and by building a 3D geometric model of plants to truly capture the combustion process of a single plant, we can further simulate forest-scale fire propagation and analyze the factors that affect forest fire spread. In addition, based on the constructed immersive forest scene, this study explored various forms of fire extinguishing methods in the virtual environment, mainly liquid flame retardants such as water guns, helicopter-dropped flame retardants, or simulated rainfall. Therefore, the forest fire occurrence, spread, and fire extinguishing process can be visualized after the interactive simulation is designed and implemented. Finally, this study greatly enhanced the immersion and realism of the 3D forest fire scene by simulating the changes in plant materials during the spread of a forest fire.
Evaluation of the Enzymatic Production and Prebiotic Activity of Galactomannan Oligosaccharides Derived from Gleditsia microphylla
Authors: Wang Hanghong , Lai Chenhuan , Tao Yuheng , Zhou Mengyi , Tang Ruilin , Yong Qiang
Published: July 2023

Oligosaccharides have received considerable attention as prebiotics because they exhibit potential health benefits related to their ability to modulate intestinal bacterial composition. This study evaluated the effects of galactomannan oligosaccharides (GMOS) derived from Gleditsia microphylla as a prebiotic on human intestinal bacteria. The β-mannanase used for the enzymatic hydrolysis of GMOS was produced by Trichoderma reesei Rut C-30. The enzymatic hydrolysis of GMOS was found to occur under optimal conditions at 50 °C, pH 5, 20 U/g-GM, and 20 g/L, and resulted in a yield of 70.78% ± 1.34%. The purity of GMOS after purification was 81.50%. Upon performing in vitro human fecal fermentation using GMOS as a carbon source, it was observed that GMOS effectively promoted the proliferation of intestinal bacteria, and the utilization efficiency of GMOS by intestinal bacteria was found to be at 98.40%. In addition, GMOS were found to have a stabilizing effect on intestinal pH. Additionally, 16S rRNA sequencing of GMOS revealed that GMOS significantly affected the diversity of gut microbiota. Specifically, GMOS exhibited a significant inhibitory effect on Fusobacteria at the phyla and genus level, and demonstrated a significant inhibitory effect on Fusobacterium. Moreover, the results for the prediction of metabolic function analysis showed that GMOS had a significant effect on the level two metabolism of carbohydrates, cofactors, and vitamins. Furthermore, during level three metabolism, the lipoic acid metabolism was significantly affected by GMOS. These results provide a theoretical basis for the potential use of galactomannan oligosaccharides from Gleditsia microphylla as prebiotics for regulating human intestinal bacteria.
Effect of Chickpea Dietary Fiber on the Emulsion Gel Properties of Pork Myofibrillar Protein
Authors: Zhao Dianbo , Yan Shuliang , Liu Jialei , Jiang Xi , Li Junguang , Wang Yuntao , Zhao Jiansheng , Bai Yanhong
Published: July 2023

In this study, the effect of chickpea dietary fiber (CDF) concentration (0%, 0.4%, 0.8%, 1.2%, 1.6%, and 2.0%) on emulsion gel properties of myofibrillar protein (MP) was investigated. It was found that the emulsifying activity index (EAI) and emulsifying stability index (ESI) of MP increased with the increasing content of CDF. Moreover, the water- and fat-binding capacity (WFB), gel strength, storage modulus (G’), and loss modulus (G”) of MP emulsion gel also increased with increasing content of CDF. When the concentration of CDF was 2%, the most significant improvement was observed for EAI, breaking force, and WFB (p < 0.05); the three-dimensional gel network structure of the MP emulsion gel was denser and the pore diameter was smaller. The T21 relaxation time of emulsion gel decreased while the PT21 increased significantly with the increasing content of CDF, suggesting that the emulsion gel with CDF had a better three-dimension network. The addition of CDF led to an increased content of β-sheet and reactive sulfhydryl and increased surface hydrophobicity of MP, thus improving the gel properties of the MP emulsion gel. In conclusion, the addition of CDF improved the functional properties and facilitated the gelation of the MP emulsion, indicating that CDF has the potential to improve the quality of emulsified meat products.
Use of Plant Extracts, Bee-Derived Products, and Probiotic-Related Applications to Fight Multidrug-Resistant Pathogens in the Post-Antibiotic Era
Authors: Machado António , Zamora-Mendoza Lizbeth , Alexis Frank , Álvarez-Suarez José Miguel
Published: July 2023

The ‘post-antibiotic’ era is near according to the World Health Organization (WHO). It is well known, due to the work of the scientific community, that drugs (antibiotics, antifungals, and other antimicrobial agents) are continuously becoming less effective, and multidrug-resistant (MDR) pathogens are on the rise. This scenario raises concerns of an impending global infectious disease crisis, wherein a simple opportunistic infection could be deadly for humans. The war against MDR pathogens requires innovation and a multidisciplinary approach. The present study provides comprehensive coverage of relevant topics concerning new antimicrobial drugs; it suggests that a combination of different natural products (such as plant extracts, honey, propolis, prebiotics, probiotics, synbiotics, and postbiotics), together with drug therapy, could be used as an adjuvant in standard treatments, thus allowing drug sensitivity in MDR pathogens to be restored, host immunity to be enhanced, and clinical efficiency to be improved. Currently, new and relevant developments in genomics, transcriptomics, and proteomics are available for research, which could lead to the discovery of new antimicrobial drugs and a new generation of antibiotics and non-antibiotics. However, several areas concerning natural products and their combination with standard drugs remain unclear. In an effort to advance new therapies for humankind, these gaps in the literature need to be addressed.