bluuebunny/crossref_metadata_2025 huggingface dataset:
Does trazodone reduce anaesthetic agent requirement in dogs?
Authors: Stewart Gemma
Published: August 2022

PICO question

In dogs undergoing anaesthesia, does the use of oral trazodone given 2 hours before induction of anaesthesia reduce injectable or inhalant anaesthetic agent requirements?

 

Clinical bottom line

Category of research question

Treatment

The number and type of study designs reviewed

Two randomised controlled trials were critically appraised

Strength of evidence

Moderate

Outcomes reported

Trazodone was shown to have a significant isoflurane minimum alveolar concentration (MAC) sparing effect for isoflurane. There is also evidence to suggest trazodone has a similar effect on the cardiovascular system as acepromazine

Conclusion

Trazodone should be considered as part of a multimodal approach to anaesthesia in dogs to reduce the injectable and inhalant anaesthetic agent requirements

 

How to apply this evidence in practice

The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.

Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
THE IMPACT OF PICTURE SERIES ON WRITING ABILITY AMONG INDONESIAN JUNIOR HIGH SCHOOL EFL LEARNERS
Authors: Ramadhanty Adinda Widya , Utomo Dhafid Wahyu , Mayasari Jalia
Published: August 2022

This study tried to shed light on investigating the impact of picture series on Indonesian Junior High School EFL learners’ abilities in English descriptive writing. To fulfill the objective, quantitative method with quasi experimental design was employed. 50 Indonesian Junior High School EFL learners were selected out of 100 students in a private Junior High School in Banten province. The sample of this research was chosen based on the non-equivalent group design technique. Moreover, the chosen participants were divided into two equal groups: experimental group and control group. In collecting the data, the researchers conducted pre-test and post-test. The data, then, were analyzed by using t-test. The result of t-test revealed that revealed that the experimental group performed better than the control group. Finally, the implications of the findings and recommendations for future research were also discussed.
Los pronombres clíticos de tercera persona en el corpus PRESEEA-Medellín
Authors:   Universidad de Antioquia, Facultad de Comunicaciones y Filología, Colombia, Dieck Marianne , González Rátiva María Claudia ,   Universidad de Antioquia, Facultad de Comunicaciones y Filología, Colombia, Areiza Juan Daniel ,   Universidad de Antioquia, Colombia, Ariza Valentina ,   Universidad de Antioquia, Colombia
Published: August 2022

This paper describes the analysis of the form, function and distribution of third person object clitic pronouns in the corpus PRESEEA-Medellín, and aims to widen the knowledge of clitic pronouns’ morphosyntactic variation in different Spanish varieties. Our findings show that the selection of the forms lo(s), la(s) and le(s) is determined by case, gender and number, independently of the animate/inanimate or continuous/discontinuous nature of the referent, which corresponds to the use of a case distinguishing system. The grammaticalization process of indirect object (IO) doubling is almost absolute (99%), and the depronominalization of le in presence of a canonic io shows an advanced degree, considering that in 61.5% cases the dative singular clitic le cooccured with a plural lexical IO in canonic position, a tendency reported for many other varieties of Spanish (see Fernández Soriano, 1999; Company, 2002; Huerta, 2005; Mojedano, 2014).
La conceptualización del núcleo en las construcciones (pseudo)partitivas: la concordancia sujeto-verbo
Authors:   Universidad de Buenos Aires, Argentina, Romero María Cecilia , Morón Usandivaras Mariana ,   Universidad de Buenos Aires / CONICET, Argentina
Published: August 2022

The aim of this work is to analyze the influence of semantic-pragmatic factors in the establishment of Spanish subject-verb agreement in those cases in which the nominal that functions as a subject is manifested through a (pseudo)partitive construction, formed by a singular nucleus + plural prepositional phrase (un grupo de neurocientíficos han decidido acabar con los interrogantes del experimento / un grupo de chicos se acercó a mí y comenzaron a golpearme). The Royal Spanish Academy defines agreement as the “formal expression of various syntactic relationships” (NGLE, 2009: 13). It states that this relationship arises from the morphological agreement between two lexical units that are in specific positions. The agreement, then, is understood, from a syntactic position, as the reiteration of inflectional information in various places in the chain. However, from cognitive linguistics, the establishment of agreement is about a conceptual superposition, a common characteristic of grammatical constructions, whereby the same information is symbolized in multiple places” (Langacker, 2008, p. 347). Based on the notions of figure and ground proposed by Langacker (1991 and 2008), our hypothesis argues that the agreement between the subject and the verb is defined, in the cases analyzed, according to the conceptualization of the nominal and which is the element that the speaker brings into focus during the construction of his speech.
“Conectados com o passado”
Authors: Ratia Katri
Published: August 2022

Os rituais contemporâneos em sítios arqueológicos exibem interpretações concorrentes do passado, futuro e de reivindicações religiosas, identitárias e políticas relacionadas – como encontrado em pesquisas sobre paganismos contemporâneos. Este artigo examina essa ritualidade e construção de tradição entre os participantes da Família Arco-Íris. Após descrever as expressões rituais relacionadas a sítios arqueológicos que são encontradas em um encontro Arco-Íris e como essas expressões se relacionam entre si no quadro da cultura coletiva, o artigo compara o caso Arco-Íris a pesquisas sobre o paganismo. O artigo fornece um exemplo de rituais e narrativas folclóricas elaborados em uma comunidade ”evento-cultural” que reconhece o direito à significação subjetiva. Explica-se como, embora não completamente convergentes, narrativas e práticas ainda podem se relacionar no quadro coletivo sem ser uma ameaça à coesão social ou coerência cultural. No caso Arco-Íris, a demanda por crenças compartilhadas é substituída pela participação em práticas compartilhadas e por uma ampla divisão ideológica que acomoda várias tradições religiosas holísticas alternativas.
Transdisciplinarity:the search for the unity of scientific and technological knowledge
Authors:   Universidade de Brasília, Alvares Lilian , Freire Patrícia ,   Universidade Federal de Santa Catarina
Published: August 2022

Introduction: Reflections about the unity of knowledge have taken place at various times in history. Modern science, however, brings in its wake the issue of disciplinary specialization, which caused a profound change in the search for scientific knowledge. The new disciplinary order, increasingly specialized, hindered the integrated vision of science and knowledge, leading to a distancing from the various realities contained in the same problem or circumstance, and even disregarding the necessary integration among knowledges. Objectives: To understand the relevance of searching for all aspects of the same situation, this research aims to deepen the contributions and understandings of some of the first thinkers who dealt with the unity of knowledge, extending to Kurt Gödel, considered as the father of transdisciplinary, and to Mode 2 of knowledge production by Michael Gibbons. Method: This study consists of an interpretivist, qualitative research, resulting in a critical literature review, which synthesized the information through evaluation and in-depth discussion about the unity of scientific and technological knowledge. Results: Unity of knowledge refers to the fact that conditioned knowledge can only achieve its integrity through unconditioned knowledge, the latter not merely a contingent aggregate, but an indispensable system for the complete identity of conditioned knowledge. Conclusion: Transdisciplinary, in this respect, is the search for the unity of knowledge, beyond disciplinary boundaries, to capture the full complexity of the multidimensional and the multi-referential Reality of the conditioned element
The singularities of work in university libraries specialized in health: the reference service in debate
Authors:   Universidade Federal de Minas Gerais, Junior Gesner , dos Reis Alcenir ,   Universidade Federal de Minas Gerais
Published: August 2022

Introduction: the reference service in university libraries specialized in health has certain singularities due to the characteristicsof the scientific field of the field of Health Sciences, the interface between teaching practices and scientific research, as well as the general profile and demands for information /reliable evidence by academics, professors/researchers and practitioners. Objective: to present and discuss the singularities of the reference service in university libraries specialized in health, as well as the challenges/potentialities of librarianship in this context. Method: The study, of theoretical character, carried out exploratory research with bibliographic research in national and international literature in the area of Librarianship/Information Science. Results: The results obtained indicate that the singularities of the work process in university libraries are determined not only by the idiosyncrasies of health personnel, but, above all, by the fact that human health (physical and mental) is the object of study and practice of area. Conclusion: It is concluded that despite the challenges related to library training in Brazil and the development of desirable and/or required skills/skills for health care, these elements do not constitute an insurmountable obstacle to professional practice with excellence. However, the librarian needs to recognize that such variables are intervening in their professional practice and that the search for improvement/specialization is a pressing demand
Formulation and Characterization of Novel Ophthalmic in Situ Gel of Flucytosine for Improved Bioavailability
Authors: Manigauha Ashish , Sunita Yadav
Published: August 2022

Flucytosine is chiefly employed in the antifungal eye drops formulation, especially recommended for treatment of serious infections. The poor bioavailability of eye drops failed to produce the maximum therapeutic effects to the patient. Hence, it was intended to prepare and evaluated in situ ophthalmic gel of Flucytosine for better therapeutic efficacy. The different proportion of the Xanthan gum and HPMC K4M along with sodium alginate were used for the preparation of in situ ophthalmic gel of Flucytosine.  The six in situ ophthalmic gels were prepared, and evaluated for clarity, visual appearance, pH, gelling capacity, drug content, assessment of drug release, kinetic modelling, ocular irritancy and stability study. The formulation demonstrated appreciable findings for all the assessment. The F2 revealed greatest drug release for 8 hrs, and it implies the sustained release compared to other formulations. Further, the F2 followed the zero order drug release. The findings concluded that in situ ophthalmic gel of Flucytosine produce better therapeutic efficacy, and also reduce the frequency instillation into eye.
Evaluation of the effect of heat on the antibacterial property of Moringa oleifera on Streptococcus pneumoniae and Staphylococcus aureus
Authors: Amisi Jim , Mwenda Joram , Obuya Joel , Imbenzi Palmer
Published: August 2022

ABSTRACT

 Moringa oleifera has been used for medicinal and nutritional purposes. No study has been done on the evaluation of the effect of heat on the antibacterial property of ethanolic extract of Moringa oleifera. The present study was done to evaluate the effect of heat on the antibacterial property of Moringa oleifera on Streptococcus pneumoniae and Staphylococcus aureus. Agar disc diffusion method was used to evaluate the antibacterial effects of the Moringa oleifera leaf extracted at 24℃ and subjected to 40℃ and 80 ℃ of heat respectively. It has been found that the extract subjected to 40℃ of heat demonstrated significant antibacterial effect (P< 0.05) on both Streptococcus pneumoniae and Staphylococcus aureus compared to the other two extracts. However, there were no significant antibacterial effect (P> 0.05) between the Moringa oleifera extracted at 24℃ and the one subjected to 80 ℃ of heat after extraction. This study has demonstrated that heating temperature affects the antibacterial property of Moringa oleifera leave’s extract.
Underlying Risk Determinants of Acute and Moderate Malnutrition in Children and its Preventive Management
Authors: Vishwakarma Bharti , Alka David
Published: August 2022

Nutritional deficiency is a significant public health concern that has serious implications for both health and socioeconomic development in low- and middle-income nations, children <5 years of age who are malnourished are most likely to suffer from severe malnutrition. Unicef's Joint Malnutrition Estimates for 2021 reveal that stunting prevalence has been falling since 2000, but in 2020, more than one in five children under the age of five were stunted, and 45.4 million children were malnourished. Associations between malnutrition and disability are becoming increasingly important on a worldwide scale, as both are major global public health issues, both are important human rights concerns, and both are now prominent on the global health agenda. Severe malnutrition is a better term for these conditions because it reflects chronic poverty, poor living conditions with pervasive deficiencies in sanitation and hygiene, a high prevalence of infectious diseases and environmental insults, food insecurity as well as poor maternal and foetal nutritional status, along with inadequate nutrition in infancy, toddlerhood, and childhood. A higher risk of serious illness and mortality is associated with children who are severely malnourished. This risk is due to acute infectious illnesses. Inadequate calorie or protein consumption causes acute malnutrition. As a result of low food availability caused by social, economic, and environmental factors, primary acute malnutrition is widespread in poor nations. As a result of acute starvation, biochemical alterations are triggered by metabolic, hormonal, and glucoregulatory processes. It is possible to treat the majority of children with primary acute malnutrition at home with nutrition-specific treatments (i.e., counselling of parents, ensuring household food security, etc.). Although alternative protein sources might result in cost reductions, there is no guarantee that they would. When it comes to treating children with mild acute malnutrition, alternative protein sources, notably plant-based protein substitutes, have shown more promise. Continued research on alternative proteins is important, given that cost is a key barrier to scaling up therapy for acute malnutrition and that other protein sources offer a feasible way to reduce cost. An overview of malnutrition is presented in this article, with a focus on therapy and therapeutic foods for malnutrition management.
A Method to Custom-build Equations of Drug Concentration as a Function of Real Time in the One-Compartment Open Model and Their Application in Multiple Intravenous Bolus and Multiple Oral Doses
Authors: Michalakis Savva
Published: August 2022

A method to custom-build expressions of drug concentration as a function of total time in a one-compartment pharmacokinetic model for multiple-dose schedules is developed and successfully applied in four dosing schedules that combined administration of multiple IV bolus and oral maintenance and loading doses. The method consists of writing the terms of the mathematical sequence from the analytical solutions to drug concentration using total time, instead of time within dosing interval, extracting the pattern of the respective sequences, and finally, determining the partial sums of the series that relate to drug concentration to dose number and real-time, for each particular administration route and dosing schedule. Multiple subroutines written in Fortran language demonstrated the potential of these equations to investigate the effect of dose size on peak plasma drug concentration and peak time after multiple oral administrations and for calculating and refining experimentally determined time-dependent pharmacokinetic parameters such as non steady-state average concentration values and Area Under the Curve (AUC). It is shown that the only truly independent of dose size peak time is that of the first oral dose (). A mathematical expression was derived that relates the time to reach non steady-state peak times after multiple oral doses to the absorption and elimination rate constants for the first time. For repetitive oral dose administration, the will always be the longest peak time, while the shortest time to reach maximum plasma drug concentration will be at steady-state conditions.
TRPV1, PPAR and SGLT-2 as a Potential Therapeutic Target for Diabetes Mellitus: Current Status and Challenges
Authors: Mauro Luisetto  , Ikbal Abu Md Ashif , Choudhury Paromita Dutta , Rajkhowa Amlanjyoti , Paul Kishan , Majumder Rima , Manna Kuntal , Sarbani Debsarkar  , Debnath Bikash , Sucheta Sen  , Wael M. Aboulthana
Published: August 2022

A chronic pathological condition; diabetes mellitus occurs in almost 90% of all diabetic cases globally. It is estimated that the number of diabetes patients will rise from 382 million in 2013 to 592 million by 2035 as per the data published by the Current International Diabetes Federation. Daily life style and day to day unhealthy food habits, diabetes is prevalent among the young people too along with the aged people due to their ageing. Diabetes mellitus is a disorder where there is insufficiency of insulin having the symptoms excessive thirst, frequent urination, fatigue, weight loss, results in blood sugar level to be drastically high. One may observe a drastic increase in blood glucose level which lead to various types of health complications like retinopathy, nerve damage etc. Various treatment strategies are available among these the modern treatment strategy includes sulfonylureas, GLP-1 agonist, DPP4- inhibitors, metformin, PPAR-γ agonists, bariatric surgery etc. In this review, we will highlight various potential therapeutic targets including TRPV1, PPAR, and SGLT-2 to mitigate diabetes mellitus.
Management of Diabetes Mellitus by Nano Based Drug Delivery with Special Reference to Phytosomes
Authors: Jiyauddin Khan  , Ikbal ABU MD ASHIF IKBAL , Debnath Bikash , Rajkhowa Amlanjyoti , Choudhury Paromita Dutta , Sen Sucheta , Paul Kishan , Choudhury Deijy , Sarbani Debsarkar  , Kulungti Jamatia  , Manna Kuntal , Ajayi Ayodeji Folorunsho
Published: August 2022

The use of Phytosomes for medicinal purposes is very much used to alleviate the harmful effects of diabetes, a common carbohydrate metabolic disease in all age groups. Over time, various newer therapies and medications have been developed to alleviate this disease. Although the traditional therapies seem to lower blood glucose levels to some extent, it is sometimes observed that these traditional therapies do not work well in some patients, which may be due to numerous other existing pathological conditions in them. To overcome these problems, small and more bioavailable formulations along with phytocomponents embedded in Phytosomes are gaining potential. This review paper mainly focuses on the mechanism of phytosome-based drug delivery for the alleviation of diabetes and a brief description of the different types of diabetes mellitus, its causes and diagnosis. By reading this article, researchers will get a brief idea of Phytosomes and their mechanism in diabetes. Phytosomes are based on the concept of delivery of lipid agents through a vesicular system.
Practical considerations in starting a peripheral lymphedema magnetic resonance imaging program
Authors: Shetty Anup S.
Published: August 2022

The management of chronic peripheral lymphedema benefits from a multidisciplinary approach in which magnetic resonance imaging (MRI) can play a key role. The imaging has been well described in the literature (including this journal), but the process for starting a novel imaging service line is complex. Participants in this process, including radiologists, imaging technical staff, information technologists, and revenue cycle managers, must be engaged and work in harmony to achieve success. The purpose of this article is to detail the building blocks and steps in starting a peripheral lymphedema MRI program, how our process evolved, and lessons learned along the way.
Section Artikel Pembinaan Industri Kecil Pemberdayaan Ekonomi Koperasi Pondok Pesantren Kukami Pembuatan Face Shield dan Masker
Authors:   Universitas Islam Nusantara, Nugroho Iwan Satriyo , Jamaludin Taufik Malik ,   Universitas Islam Nusantara
Published: August 2022

Pandemi Covid -19 menyebabkan dampak ancaman dan penurunan kesehatan dan perekonomian. Pondok Pesantren merupakan salah satu organisai yang terdampak pandemi yakni Pondok Pesantren As-Syifa yang membimbing 59 anak yatim dan dhuafa di Kecamatan Majalaya Kabupaten Bandung. Pondok pesantren yang menjalankan usaha mandiri dalam wadah koperasi pondok pesantren (kopotren) yaitu konveksi baju anak dan remaja sempat mengalami kesulitan karena dampak pandemi. Dosen dan mahasiswa Universitas Islam Nusantarabeserta pondok pesantren melakukan alih usaha untuk secara mandiri mengelola pondoknya. Usaha pembuatan masker dan face shield yang sekaligus menjadi penguatan kontribusi dalam mengatasi sebaran pandemi Covid -19 nyata telah memberikan hasil, Dengan penghasilan dari usaha ini selama 1 tahun pondemi pondok pesantren tetap berkecukupan dan mandiri.
Producción de múltiples pozos en yacimientos rectangulares naturalmente fracturados con entradas a producción a diferentes tiempos
Authors: Ávalos Milla Marco Antonio , Camacho Velázquez Rodolfo Gabriel
Published: August 2022

En este trabajo se presentan por primera vez dos soluciones analíticas para predecir el perfil de producción de múltiples pozos trabajando a diferentes presiones de fondo constantes, que inician su producción a diferentes tiempos en yacimientos naturalmente fracturados rectangulares con fronteras cerradas al flujo y espesor constante; una para doble porosidad (matriz y fracturas) y la segunda para yacimientos de triple porosidad (matriz, fracturas y cavidades de disolución-vúgulos), ambos con una permeabilidad. Para el caso de doble porosidad, la red de fracturas es la que conduce los fluidos hacia los pozos productores, y en el caso de triple-porosidad, la red de fracturas o la de vúgulos conduce los fluidos hacia el/los pozos. Se presentan, además, sus inversiones analíticas del espacio de Laplace al espacio real, aproximadas para tiempos grandes. Las soluciones analíticas fueron invertidas del espacio de Laplace utilizando aproximaciones a tiempos largos, las cuales fueron validadas comparando los resultados con simuladores numéricos. De la misma manera se presentan los resultados de variar los coeficientes de flujo interporoso y las relaciones de almacenamiento de fluidos, observándose comportamientos específicos para cada tipo de yacimiento. Por último, se presenta un contraste en el que se comparan los resultados de un medio poroso homogéneo (1-ϕ), con la variedad de resultados que se pueden obtener si se considera que el yacimiento es de doble porosidad (2-ϕ) o de triple porosidad (3-ϕ). Los modelos propuestos son útiles para predecir el comportamiento de múltiples pozos produciendo de yacimientos naturalmente fracturados con doble porosidad (2-ϕ) y triple porosidad (3-ϕ), así como para realizar análisis económicos de diferentes esquemas de desarrollo de campos cuando la información disponible no justifica el uso de simuladores numéricos.
El compromiso ambiental y social, los nuevos retos y las perspectivas de los ingenieros de ríos en Latinoamérica
Authors: Núñez-González Francisco , Roger Gutiérrez Ronald
Published: August 2022

La ingeniería de ríos ha proporcionado los elementos teóricos, empíricos y prácticos para intervenir en los cursos fluviales con la finalidad de aprovechar los recursos hídricos o de reducir los riesgos de daño a poblaciones e infraestructuras. Tradicionalmente, el ingeniero hidráulico con especialidad en ingeniería de ríos ha emprendido estas acciones mediante soluciones que se pueden denominar como “rígidas” o “duras”, por los materiales y las técnicas constructivas empleadas, pero también por la filosofía subyacente, que favorece las actuaciones sobre los efectos visibles, antes que sobre las causas. Sin embargo, en las últimas décadas nuestras sociedades han experimentado un cambio en su percepción y relación con el ambiente, el cual propugna como valores fundamentales el buen estado de los ecosistemas acuáticos y una gestión sostenible de los recursos hídricos. Este cambio de paradigma implica una profunda revisión del papel del ingeniero de ríos en la planificación, intervención y gestión de los espacios fluviales, asumiendo un giro sustancial en el enfoque de las actuaciones, así como la necesidad de colaboración estrecha con profesionales de diversas disciplinas. En este trabajo se discute el nuevo papel del ingeniero de ríos y los retos a los que ha de hacer frente en las sociedades latinoamericanas. En particular se hace énfasis en la singularidad ambiental y social de la región, que requiere del ingeniero de ríos nuevas competencias técnicas, pero también compromiso ambiental y social, así como una participación activa como enlace entre expertos de diversa índole, la sociedad y las autoridades.
Parenting-allocated time in families of the Ural Russian region: amounts and determinants
Authors: Voroshilova Anzhelika , Bagirova Anna
Published: August 2022

This study aims to measure the time allocated to child raising using parents’ self-assessment and the criterion of subjective time sufficiency or insufficiency. We surveyed 545 Russian parents from the Ural region and used factor analysis to identify the main determinants that affect the self-assessment of time allocated to parenting. We found that parents in the Russian Ural region believe they do not spend enough time with their children. Reasons for the insufficient amount of time allocated to parenting are the following: overload of labor duties at home and at work, psychological causes of intergenerational interaction, external reasons − studies, poor health, the need to care for other relatives and so on.
Analysis of Seakeeping And Motion Sickness Incidence (MSI) Prediction Of The Ship's Bow When Sailing In Cilacap Sea
Authors: Yusim Adi Kurniawan , Hasrianti Besse
Published: August 2022

The waves are quite large, and the ship's movement continues to be a barrier tossed about or up and down on the high seas. It can result in symptoms of illness or an uncomfortable atmosphere for passengers on board. This symptom is often referred to as seasickness or motion sickness. The main cause of seasickness is the absence of similarity of excitability or conformity between the stimulus, eye and ear labyrinth the human brain receives. Usually, people who get seasick are on closed decks because their eyes cannot see any movement. At the same time, the ear labyrinth responds to the ship's movement so that there is a conflict between the stimuli received by the eyes and the ear labyrinth, which is responsible for body balance, causing nausea. In severe cases, passengers or crew must be taken to the hospital. Modelling MSI on Finite Element Method Software, it can be seen that passengers experience ship sickness or, in this case, experience MSI at what time on a cruise on the Cilacap sea lane processed to determine the condition of the ship's MSI to passengers by the acquisition of 6 degrees of freedom where various components that affect such as wind, the main current is a wave it occurs 6 degrees of freedom, i.e. Surging is a translational movement along the X axis, Rolling is the movement of the ship around the X axis, Swaying is the translational movement of the ship that occurs when the ship moves along the Y axis, Pitching is the movement of the ship around the Y axis, Heaving is the movement of the ship along the Z axis. A ship with a speed of 12.5 knots sailing in the Cilacap sea with a wave height reaching an average wave of 2.5 meters, the MSI of the ship occurs, namely the effect of sea conditions on the movement of the ship indicating that the ship's response to the sea is at 90 degrees. In the opposite direction of the wave, MSI occurs in 20% of passengers after 2 hours on the vehicle deck at the bow point. At that time, the magnitude of the encounter frequency was 2.137 Hz.
You can go your own way : no evidence for social behavior based on kinship or familiarity in captive juvenile box turtles
Authors: Tetzlaff Sasha , Sperry Jinelle , DeGregorio Brett
Published: August 2022

Behavioral interactions between conspecific animals can be influenced by relatedness and familiarity. To test how kinship and familiarity influenced social behavior in juvenile Eastern Box Turtles (Terrapene carolina), 16 captive-born individuals were reared under semi-natural conditions in four equally sized groups, where each group comprised pairs of siblings and non-siblings. Using separation distance between pairs of turtles in rearing enclosures as a measure of gregariousness, we found no evidence suggesting siblings more frequently interacted with one another compared to non-relatives over the first five months of life. Average pair separation distance decreased during this time but may have been due to turtles aggregating around resources like heat and moist retreat areas as colder temperatures approached. At eight months old, we again measured repeated separation distances between unique pair combinations and similarly found no support for associations being influenced by kinship. Agonistic interactions between individuals were never observed. Based on our results, group housing and rearing of juvenile box turtles did not appear to negatively impact their welfare. Unlike findings for other taxa, our results suggest strategically housing groups of juvenile T. carolina to maintain social stability may not be an important husbandry consideration when planning releases of captive-reared individuals for conservation purposes.
Photo-Fenton performance and mechanism of g-C3N4/FeOCl nanocomposite under simulate sunlight
Authors: huan majinhuan , Wei Zhiqiang , Lu Qiang , Li Chao , Li Ling
Published: August 2022

g-C3N4/FeOCl nanocomposites are prepared by a simple calcination method according to the different composite mass ratios of g-C3N4 and FeOCl. The structural and morphological characterization of the composite samples by XRD and SEM and TEM revealed the presence of g-C3N4 around FeOCl, but did not change FeOCl crystal structure. The pH range of the composites was found to be wide from the photo-Fenton experiments, and the adsorption and photo-Fenton performance were good under weak alkaline conditions. Moreover, the photocatalytic experiments from the composite samples revealed that the presence of g-C3N4 improved the light catalystic performance of FeOCl. This is attributed to the formation of Z-type heterojunctions by the composite of FeOCl and g-C3N4, which reduces the carriers complexation efficiency. ·OH plays a major role in the removal of organic matter from water. The cyclic stability properties of the composites are excellent, which implies a great prospect for industrial use. In this work, the high-efficiency photo-Fenton performance of g-C3N4/FeOCl-2 provides a new idea about the modification of pure FeOCl.
Ultra-sensitive label-free deep profiling of N-glycans released from biomedically-relevant samples
Authors: MARIE Anne-Lise , Ray Somak , Ivanov Alexandar
Published: August 2022

Protein glycosylation profiles can serve as sensitive and specific disease biomarkers. Labeling procedures for improved separation and detectability of oligosaccharides have several drawbacks, including incomplete derivatization, side-products, noticeable desialylation/defucosylation, sample loss, and interference with downstream analysis. We developed a novel label-free workflow based on high sensitivity capillary zone electrophoresis-mass spectrometry (CZE-MS) for profiling of native underivatized released N-glycans that resulted in > 45-fold increase in signal intensity compared to conventional techniques. Qualitative and quantitative N-glycan profiling of purified human serum IgG, bovine serum fetuin, bovine pancreas ribonuclease B, blood-derived extracellular vesicle isolates, and total plasma resulted in detection of > 250, >400, > 150, >310, and > 520 N-glycans, respectively, using injected amounts equivalent to < 25 ng of model protein and nL-levels of plasma-derived samples. Compared to reported results for biological samples of similar amounts and complexity, the number of identified N-glycans was increased up to ~ 15-fold. Also, previously undetected highly sialylated N-glycans were identified and structurally characterized. For the first time, untreated sialic acid-linkage isomers were resolved in a single CZE-MS analysis.
Prevalence and Psychosocial Correlates of Cyberbullying among Adolescents in Saint Vincent and the Grenadines
Authors: Mireku Dickson Okoree , Sarfo Jacob Owusu , Seidu Abdul-Aziz , Ahinkorah Bright Opoku
Published: August 2022

Cyberbullying is presently a growing public health concern, especially among adolescents. This study investigated the prevalence and psychosocial correlates of cyberbullying among in-school adolescents in Saint Vincent and the Grenadines. We explored the 2018 Saint Vincent and the Grenadines’ Global School-based Health Survey with a sample size of 1,877 in-school teenagers (aged 11 - 18 years old). Using a binomial logistic regression modelling, statistically estimated Adjusted Odds Ratios (AOR) at a 95% confidence interval were utilised to determine the predictors of cyberbullying. Results showed a 15.7% (10.8% males vs 20.5% females) prevalence of cyberbullying among in-school teenagers. Also, psychosocial correlates like being a female, being physically attacked, being involved in a physical fight, being bullied on a school property, being bullied off a school property, having ever considered suicide, and ever had sex significantly predicted cyberbullying. Further, school-based health interventions focusing on the identified psychosocial correlates are required to mitigate cyberbullying in Saint Vincent and the Grenadines.
Pharmacodynamic modeling of moderate sedation and rationale for dosing using midazolam, propofol and alfentanil
Authors: Liou Jing-Yang , Kuo I-Ting , Chang Weng-Kuei , Ting Chien-Kun , Tsou Mei-Yung
Published: August 2022

Purpose: Regulations have broadened to allow moderate sedation administration for gastrointestinal endoscopy by non-anesthesia personnel. The line between moderate and deep sedation is ambiguous. Deep sedation offers patient comfort as well as greater safety concerns. Unintended deep sedation can occur if drug interactions are overlooked. We present a pharmacodynamic model for moderate sedation using midazolam, alfentanil and propofol. The model is suitable for training and devising rationales for appropriate dosing.Methods: The study consists of two parts: modeling and validation. In modeling, patients scheduled for esophagogastroduodenoscopy (EGD) or colonoscopy sedation are enrolled. The modified observer’s assessment of alertness/sedation (MOAA/S) score < 4 is defined as loss of response to represent moderate sedation. Two patient groups receiving bronchoscopy or endoscopic retrograde cholangiopancreatography (ERCP) are used for validation. Model performance is assessed by receiver operating characteristic (ROC) curves and area under the curve (AUC). Simulations are performed to demonstrate how the model is used to rationally determine drug regimen for moderate sedation.Results: Interaction between propofol and alfentanil is stronger than the other pairwise combinations. Additional synergy is observed with three drugs. ROC AUC is 0.83 for the modeling group, and 0.96 and 0.93 for ERCP and bronchoscopy groups respectively. Model simulation suggests that 1mg midazolam, 250μg alfentanil and propofol maximally benefits from drug interactions and suitable for moderate sedation.Conclusion: We demonstrate the accurate prediction of a three-drug response surface model for moderate sedation and simulation suggests a rational dosing strategy for moderate sedation with midazolam, alfentanil and propofol.
Live video streaming of neurology ward rounds for undergraduate medical students can replace conventional bedside teaching
Authors: Sekiguchi Kenji , Kawano Seiji , Chihara Norio , Kobayashi Seimi , Maeda Eiichi , Matsumoto Riki
Published: August 2022

Background
Although teaching ward rounds of the neurology department are considered amongst the most important educational exercises during medical learning in Japan, they are beset by several issues. Patients may find it unpleasant to undergo repeated neurological tests and think that they are being put on display in the presence of several students. However, unfortunately, only the students standing in the front row can closely observe the examination findings. Moreover, students were prohibited contact with patients during the coronavirus pandemic. To overcome these problems, we developed a secure on-premises video conferencing system for conducting live video neurology ward rounds to replace conventional bedside ward rounds
Methods
We created an on-premises web conferencing system called the Kobe University School of Medicine Web Conference Lecture System (KUMEX), which can be operated only within the hospital, using BigBlueButton, an open-source conferencing application based on Web Real-Time Communication. We attempted to broadcast live videos of the professor’s ward rounds to medical students located in a separate room. Studies were provided questionnaires to evaluate the utility and feasibility of participation in remote ward rounds.
Results
The students watched a live-streamed video of a professor examining an inpatient on a large screen in the conference room. Each examination technique was explained to the students by another teacher, who could immediately answer questions without worrying about the patient. Characteristic findings, such as plantar reflexes and fasciculations of the tongue, which are usually seen only by the students in the front rows during normal faculty rounds, could be observed under magnification by all students. This program was rated as fair or excellent by 93.7% of students who participated in the remote rounds.
Conclusion
Live-streaming of neurology ward rounds using an on-premises secure in-house web conferencing system enabled a novel style of clinical neurology education without hampering trust in the patient-physician relationship and could replace conventional bedside teaching.
Do you “Go big or go home” with Neural Networks?
Authors: Dahal Ashim
Published: August 2022

This paper includes study of three different text generation model approaches to test impacts on feasibility in fidelity of results while making inferior changes to data preprocessing and simultaneously increasing the models size. Chicken recipes found online were used to train text generative models for evaluation. The general theme that emerged as the result of this experiment was: the outcome of a model is dictated not only by how big it is but by how well the data was processed for it.
Sphingosine 1-phosphate Receptor 2 Mediated Early Stages of Pancreatic and Systemic Inflammatory Response via NF-kappa B Activation in Acute Pancreatitis
Authors: Yang Jing , Tang Xujiao , Li Baiqiang , Shi Jinsong
Published: August 2022

In acute pancreatitis (AP), activation of inflammatory signaling including nuclear factor-kappa B (NF-κB) pathway within acinar cells is known to be an early intracellular event occurring in parallel with pathologic trypsinogen activation. Sphingosine 1-phosphate Receptor 2 (S1PR2) plays a critical role in endothelial inflammation and our previous studies reported that S1PR2 deficiency significantly reduced inflammatory response in liver injury under cholestasis conditions. However, the role of S1PR2 in inflammatory signaling activation within acinar cells and inflammatory responses during acute pancreatitis has not been elucidated. Here we report that S1PR2 was upregulated in whole pancreas during acute pancreatitis conditions. Blockade of S1PR2 by pharmacologic inhibition of S1PR2 by JTE-013 or AAV-mediated knockdown of S1PR2 improved the severity of pancreatic injury as indicated by significant reduction of inflammation and acinar cells death in acute pancreatitis mice. Moreover, S1PR2 is the predominant S1PRs expressed in pancreatic acinar cells and mediates NF-κB activation and early inflammatory response within acinar cell under acute pancreatitis conditions via ROCK signaling pathways, not extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. In addition, S1PR2 mediated macrophages NF-κB activation, migration and polarization toward M1 phenotype. Therefore, this results demonstrated that S1PR2-mediated early inflammatory response in acinar cell promote the progression of acute pancreatitis, successfully linking the local events to the systematic inflammatory response and leading a novel therapeutic target for acute pancreatitis aimed at halting the progression of inflammatory response.
Design, Modelling and Fabrication of Multi-directional Inertial Sensor
Authors: Mohammad Taj , Vikram G N V R
Published: August 2022

This research paper presents the analysis of multi-directional capacitive MEMS (Microelectromechanical system) based inertial sensors. Mathematical modelling has been derived for the proposed structures, beam constant and displacement analysis have been done. The displacement momentum and natural frequency analysis are studied and simulated using COMSOL Multiphysics software. Mathematical modelling and simulation were done for the accelerometer for up to 30g and the capacitive sensitivity were also calculated for the proposed sensors, capacitive sensitivity for the proposed sensors is 621.9241fF/g, 621.9241fF/g and 681.2889fF/g. The maximum displacement is observed for the sensors is 1.6um,0.3um and 0.2um with an eigenfrequency of 122KHz. Along with this natural frequency, analysed the quality factor for the proposed structures were observed as 4.06. Fabrication is done with the SOIMUMPS process and SEM characterization is accomplished for the proposed structures.
The association between anticholinergic burden and mobility: A systematic review and meta-analyses
Authors: Phutietsile Geofrey O. , Fotaki Nikoletta , Jamieson Hamish A. , Nishtala Prasad S.
Published: August 2022

Background: As people age, they accumulate several health conditions, requiring the use of multiple medications (polypharmacy) to treat them. One of the challenges with polypharmacy is the associated increase in anticholinergic exposure to older adults. In addition, several studies suggest an association between anticholinergic burden and declining physical function in older adults.Objective/Purpose: This systematic review aimed to synthesise data from published studies regarding the association between anticholinergic burden and mobility. The studies were critically appraised for the strength of their evidence.Methods: A systematic literature search was conducted across four electronic databases, EMBASE, CINHL, PSYCHINFO and MEDLINE, from inception to December 2021, to identify studies on the association of anticholinergic burden with mobility. The search was performed following a strategy that converted concepts in the PICO elements into search terms, focusing on terms most likely to be found in the title and abstracts of the studies. For observational studies, the risk of bias was assessed using the Newcastle Ottawa Scale, and the Cochrane risk of bias tool was used for randomised trials. For the meta-analyses, we explored the heterogeneity using the Q test and I2 test and the publication bias using the funnel plot and Egger’s regression test. The meta-analyses were performed using Jeffreys’s Amazing Statistics Program (JASP). Results: 16 studies satisfied the inclusion criteria from an initial 372 studies. Fifteen studies identified a significant negative association of anticholinergic burden with mobility measures. One study did not find an association between anticholinergic intervention and mobility measures. Five studies included in the meta-analyses showed that anticholinergic burden significantly decreased walking speed (0.079m/s ±0.035 MD±SE,95% CI: 0.010 to 0.149, p=0.026), whilst a meta-analysis of four studies showed that anticholinergic burden significantly decreased physical function as measured by three variations of the Instrumental Activities of Daily Living (IADL) instrument 0.27±0.12 (SMD±SE,95% CI: 0.03 to 0.52), p=0.027. Egger’s test did not reveal publication bias.Conclusion: There is consensus in published literature suggesting a clear association between anticholinergic burden and mobility. Consideration of cognitive anticholinergic effects may be important in interpreting results regarding the association of anticholinergic burden and mobility as anticholinergic drugs may affect mobility through cognitive effects
Machine Learning Based Modelling of Economic Growth and Quality of Governance: The MENA Region
Authors: Farjallah nadia , Sghaier Asma
Published: August 2022

Governance (which entails transparency, accountability, the rule of law and the presence of effective and legitimate institutions) is considered an essential factor in economic development. A large number of academic studies have attempted to identify and explain the influence of governance quality on economic growth, bearing on different theoretical perspective and using a panoply of estimation methods, including correlation and regression analyses. This study approaches the phenomenon from a predictive analytical perspective using contemporary Machine Learning techniques to uncover the most important predictors of economic growth in the MENA region in sample observed from 1996 to 2020. Random Forest algorithm was used with three machine learning models (Support Vector Machine, Boosted TREE, Linear Regression) to predict economic growth. The empirical results indicated that the predictions obtained using Random Forest were more accurate than those obtained by the other models. The results indicated that Government Effectiveness, Control of Corruption and Rule of Law are the most influential factors explaining economic growth.
A novel analytical approach to micropolar nanofluid thermal analysis in the presence of thermophoresis, brownian motion, and hall currents
Authors: Jalili Payam , Narimisa hossein , Jalili Bahram , Shateri Amirali , Ganji Davood Domiri
Published: August 2022

The present study analyzed micro-polar nanofluid in a rotating system between two parallel plates with electric and magnetic fields. The fluid flow study was performed in a steady state. The governing equations of the present issue are considered coupled and nonlinear equations with proper similar variables. Numerical and new semi-analytical methods have been employed to solve the problem to define the exactness of the results. The influence of physical parameters governing the problem is investigated and illustrated in detail in the diagram. Results show that velocity profile and micro-rotation velocity increased when the magnetic parameter increased. Furthermore, the velocity is increased by increasing the rotation parameter. Also, in the case of the temperature profile, the Reynolds and Schmidt number has an inverse effect, and Prandtl Number and Brownian motion have a direct effect. Other results indicate that concentration value declines by increasing the Thermophoretic parameter and Reynolds number. Results compare to the prior research display good accuracy and efficiency.