bluuebunny/crossref_metadata_2025 huggingface dataset:
Plasma concentrations of progesterone in the preceding estrous cycle are associated with the intensity of estrus and fertility of Holstein cows
Authors: Madureira Augusto M. L. , Burnett Tracy A. , Borchardt Stefan , Heuwieser Wolfgang , Baes Christine F. , Vasconcelos Jose L. M. , Cerri Ronaldo L. A.
Published: August 2021

The aim of this study was to determine the association between concentrations of progesterone (P4) during previous the estrous cycle with the intensity of spontaneous or estrogen-induced estrous expression and pregnancy per artificial insemination (P/AI). A total of 1,953 AI events from lactating Holstein cows were used, consisting of 1,289 timed AI events from experiment 1 (Exp. 1) and 664 AI events from experiment 2 (Exp. 2). In Exp. 1, cows were bred after a timed AI protocol based on estradiol and P4. In Exp. 2 animals were bred upon spontaneous estrus detection. In both experiments cows were continuously monitored by an automated activity monitor (AAM), in Exp.1 a relative increase of activity was calculated (i.e., percentage of increase activity at estrus compared to cow’s baseline activity) and in Exp.2, activity data from each cow were computed into an index value that ranged from 0 to 100. In Exp.2 duration (hours) of estrus were calculated and defined as the total time above the threshold (35 index). The intensity of estrous expression was determined for each event and classified as either high or low intensity using the median of each experiment. Blood samples were collected for P4 analysis in Exp. 1 at –4 d, 0 d, and 7 d relative to timed AI, and in Exp. 2 immediately following estrus (0 d), 7 d, 14 d, and 21 d post-AI. Concentration of P4 was classified as greater or lower according to the median value in each experiment. Cows with lower concentrations of P4 at AI had greater estrous expression in Exp. 1 (363.6 ± 5.2 vs. 275.9 ± 8.0% relative increase) and Exp. 2 (76.7 ± 1.9 vs. 67.4 ± 4.7 index; and 12.5 ± 0.5 vs. 9.3 ± 1.8 hours). Cows with a greater intensity of estrous expression at timed AI had greater concentrations of P4 at –4 d than cows with lower intensity estrus or no estrous expression (4.6 ± 0.2 vs. 3.6 ± 0.2 vs. 3.7 ± 0.2 ng/mL). Cows with greater concentrations of P4 at –4 d had greater P/AI (32.8 ± 4.4 vs. 22.4 ± 4.5%), whereas cows with lesser concentrations of P4 at d0 for either timed AI (35.2 ± 3.4 vs. 19.6 ± 4.6%) or spontaneous estrus (31.8 ± 2.8 vs. 23.4 ± 3.2%) had greater P/AI. Cows with greater concentrations of P4 7 d post-timed AI had greater P/AI compared with cows that had lower concentration of P4 (39.1 ± 2.9 vs. 24.7 ± 2.6%). Similarly, cows that had lower concentrations of P4 at 7 d, 14 d and 21 d post-spontaneous estrus tended to have lower P/AI when compared with cows with greater concentrations of P4. Overall, concentrations of P4 prior to and at AI were associated with greater estrous intensity and P/AI at both spontaneous and timed AI events.
Development and validation of FootNet; a new kinematic algorithm to improve foot-strike and toe-off detection in treadmill running
Authors: Rivadulla Adrian , Chen Xi , Weir Gillian , Cazzola Dario , Trewartha Grant , Hamill Joseph , Preatoni Ezio
Published: August 2021

The accurate detection of foot-strike and toe-off is often critical in the assessment of running biomechanics. The gold standard method for step event detection requires force data which are not always available. Although kinematics-based algorithms can also be used, their accuracy and generalisability are limited, often requiring corrections for speed or foot-strike pattern. The purpose of this study was to develop FootNet, a novel kinematics and deep learning-based algorithm for the detection of step events in treadmill running. Five treadmill running datasets were gathered and processed to obtain segment and joint kinematics, and to identify the contact phase within each gait cycle using force data. The proposed algorithm is based on a long short-term memory recurrent neural network and takes the distal tibia anteroposterior velocity, ankle dorsiflexion/plantar flexion angle and the anteroposterior and vertical velocities of the foot centre of mass as input features to predict the contact phase within a given gait cycle. The chosen model architecture underwent 5-fold cross-validation and the final model was tested in a subset of participants from each dataset (30%). Non-parametric Bland-Altman analyses (bias and [95% limits of agreement]) and root mean squared error (RMSE) were used to compare FootNet against the force data step event detection method. The association between detection errors and running speed, foot-strike angle and incline were also investigated. FootNet outperformed previously published algorithms (foot-strike bias = 0 [–10, 7] ms, RMSE = 5 ms; toe-off bias = 0 [–10, 10] ms, RMSE = 6 ms; and contact time bias = 0 [–15, 15] ms, RMSE = 8 ms) and proved robust to different running speeds, foot-strike angles and inclines. We have made FootNet’s source code publicly available for step event detection in treadmill running when force data are not available.
Pigment analysis based on a line-scanning fluorescence hyperspectral imaging microscope combined with multivariate curve resolution
Authors: Lian Lijin , Hu Xuejuan , Huang Zhenhong , Hu Liang , Xu Lu
Published: August 2021

A rapid and cost-effective system is vital for the detection of harmful algae that causes environmental problems in terms of water quality. The approach for algae detection was to capture images based on hyperspectral fluorescence imaging microscope by detecting specific fluorescence signatures. With the high degree of overlapping spectra of algae, the distribution of pigment in the region of interest was unknown according to a previous report. We propose an optimization method of multivariate curve resolution (MCR) to improve the performance of pigment analysis. The reconstruction image described location and concentration of the microalgae pigments. This result indicated the cyanobacterial pigment distribution and mapped the relative pigment content. In conclusion, with the advantage of acquiring two-dimensional images across a range of spectra, HSI conjoining spectral features with spatial information efficiently estimated specific features of harmful microalgae in MCR models.
Trends of global health literacy research (1995–2020): Analysis of mapping knowledge domains based on citation data mining
Authors: Qi Shaojie , Hua Fengrui , Xu Shengyuan , Zhou Zheng , Liu Feng
Published: August 2021

Background

During uncertainties associated with the COVID-19 pandemic, effectively improving people’s health literacy is more important than ever. Drawing knowledge maps of health literacy research through data mining and visualized measurement technology helps systematically present the research status and development trends in global academic circles.

Methods

This paper uses CiteSpace to carry out a metric analysis of 9,492 health literacy papers included in Web of Science through mapping knowledge domains. First, based on the production theory of scientific knowledge and the data mining of citations, the main bodies (country, institution and author) that produce health literacy knowledge as well as their mutual cooperation (collaboration network) are both clarified. Additionally, based on the quantitative framework of cocitation analysis, this paper introduces the interdisciplinary features, development trends and hot topics of the field. Finally, by using burst detection technology in the literature, it further reveals the research frontiers of health literacy.

Results

The results of the BC measures of the global health literacy research collaboration network show that the United States, Australia and the United Kingdom are the major forces in the current international collaboration network on health literacy. There are still relatively very few transnational collaborations between Eastern and Western research institutions. Collaborations in public environmental occupational health, health care science services, nursing and health policy services have been active in the past five years. Research topics in health literacy research evolve over time, mental health has been the most active research field in recent years.

Conclusions

A systematic approach is needed to address the challenges of health literacy, and the network framework of cooperation on health literacy at regional, national and global levels should be strengthened to further promote the application of health literacy research. In the future, we anticipate that this research field will expand in two directions, namely, mental health literacy and eHealth literacy, both of which are closely linked to social development and issues. The results of this study provide references for future applied research in health literacy.
Differences in the characteristics and contemporary cardiac outcomes of patients with light-chain versus transthyretin cardiac amyloidosis
Authors: Itzhaki Ben Zadok Osnat , Vaturi Mordehay , Vaxman Iuliana , Iakobishvili Zaza , Rhurman-Shahar Noa , Kornowski Ran , Hamdan Ashraf
Published: August 2021

Aims

To compare the baseline cardiovascular characteristics of immunoglobulin light-chain (AL) and amyloid transthyretin (ATTR) cardiac amyloidosis (CA) and to investigate patients’ contemporary cardiac outcomes.

Methods

Single-center analysis of clinical, laboratory, echocardiographic and cardiac magnetic resonance imaging (CMRi) characteristics of AL and ATTR-CA patients’ cohort (years 2013–2020).

Results

Included were 67 CA patients of whom 31 (46%) had AL-CA and 36 (54%) had ATTR-CA. Patients with ATTR-CA versus AL-CA were older (80 (IQR 70, 85) years versus 65 (IQR 60, 71) years, respectively, p<0.001) with male predominance (p = 0.038). Co-morbidities in ATTR-CA patients more frequently included diabetes mellitus (19% versus 3.0%, respectively, p = 0.060) and coronary artery disease (39% versus 10%, respectively, p = 0.010). By echocardiography, patients with ATTR-CA versus AL-CA had a trend to worse left ventricular (LV) ejection function (50 (IQR 40, 55)% versus 60 (IQR 45, 60)%, respectively, p = 0.051), yet comparable LV diastolic function. By CMRi, left atrial area (31 (IQR 27, 36)cm2 vs. 27 (IQR 23, 30)cm2, respectively, p = 0.015) and LV mass index (109 (IQR 96, 130)grams/m2 vs. 82 (IQR 72, 98)grams/m2, respectively, p = 0.011) were increased in patients with ATTR-CA versus AL-CA. Nevertheless, during follow-up (median 20 (IQR 10, 38) months), patients with AL-CA were more frequently admitted with heart failure exacerbations (HR 2.87 (95% CI 1.42, 5.81), p = 0.003) and demonstrated increased mortality (HR 2.51 (95%CI 1.19, 5.28), p = 0.015).

Conclusion

Despite the various similarities of AL-CA and ATTR-CA, these diseases have distinct baseline cardiovascular profiles and different heart failure course, thus merit tailored-cardiac management.
Dynamic physiological responses in obese and non-obese adults submitted to cardiopulmonary exercise test
Authors: Gonze Bárbara de Barros , Ostolin Thatiane Lopes Valentim Di Paschoale , Barbosa Alan Carlos Brisola , Matheus Agatha Caveda , Sperandio Evandro Fornias , Gagliardi Antônio Ricardo de Toledo , Arantes Rodolfo Leite , Romiti Marcello , Dourado Victor Zuniga
Published: August 2021

Purpose

Obese individuals have reduced performance in cardiopulmonary exercise testing (CPET), mainly considering peak values of variables such as oxygen uptake (V˙O2), carbon dioxide production (V˙CO2), tidal volume (Vt), minute ventilation (V˙E) and heart rate (HR). The CPET interpretation and prognostic value can be improved through submaximal ratios analysis of key variables like ΔHR/ΔV˙O2, ΔV˙E/ΔV˙CO2, ΔV˙C/Δlinearized (ln)V˙E and oxygen uptake efficiency slope (OUES). The obesity influence on these responses has not yet been investigated. Our purpose was to evaluate the influence of adulthood obesity on maximal and submaximal physiological responses during CPET, emphasizing the analysis of submaximal dynamic variables.

Methods

We analyzed 1,594 CPETs of adults (755 obese participants, Body Mass Index ≥ 30 kg/m2) and compared the obtained variables among non-obese (normal weight and overweight) and obese groups (obesity classes I, II and III) through multivariate covariance analyses.

Result

Obesity influenced the majority of evaluated maximal and submaximal responses with worsened CPET performance. Cardiovascular, metabolic and gas exchange variables were the most influenced by obesity. Other maximal and submaximal responses were altered only in morbidly obese. Only a few cardiovascular and ventilatory variables presented inconsistent results. Additionally, Vtmax, Vt/V˙E, Vt/Inspiratory Capacity, Vt/Forced Vital Capacity, Lowest V˙E/V˙CO2, ΔV˙E/ΔV˙CO2, and the y-intercepts of V˙E/V˙CO2 did not significantly differ regardless of obesity.

Conclusion

Obesity expressively influences the majority of CPET variables. However, the prognostic values of the main ventilatory efficiency responses remain unchanged. These dynamic responses are not dependent on maximum effort and may be useful in detecting incipient ventilatory disorder. Our results present great practical applicability in identifying exercise limitation, regardless of overweight and obesity.
Adenomatous Polyposis Coli loss controls cell cycle regulators and response to paclitaxel in MDA-MB-157 metaplastic breast cancer cells
Authors: Astarita Emily M. , Maloney Sara M. , Hoover Camden A. , Berkeley Bronwyn J. , VanKlompenberg Monica K. , Nair T. Murlidharan , Prosperi Jenifer R.
Published: August 2021

Adenomatous Polyposis Coli (APC) is lost in approximately 70% of sporadic breast cancers, with an inclination towards triple negative breast cancer (TNBC). TNBC is treated with traditional chemotherapy, such as paclitaxel (PTX); however, tumors often develop drug resistance. We previously created APC knockdown cells (APC shRNA1) using the human TNBC cells, MDA-MB-157, and showed that APC loss induces PTX resistance. To understand the mechanisms behind APC-mediated PTX response, we performed cell cycle analysis and analyzed cell cycle related proteins. Cell cycle analysis indicated increased G2/M population in both PTX-treated APC shRNA1 and parental cells, suggesting that APC expression does not alter PTX-induced G2/M arrest. We further studied the subcellular localization of the G2/M transition proteins, cyclin B1 and CDK1. The APC shRNA1 cells had increased CDK1, which was preferentially localized to the cytoplasm, and increased baseline CDK6. RNA-sequencing was performed to gain a global understanding of changes downstream of APC loss and identified a broad mis-regulation of cell cycle-related genes in APC shRNA1 cells. Our studies are the first to show an interaction between APC and taxane response in breast cancer. The implications include designing combination therapy to re-sensitize APC-mutant breast cancers to taxanes using the specific cell cycle alterations.
A prediction method of fire frequency: Based on the optimization of SARIMA model
Authors: Ma Shuqi , Liu Qianyi , Zhang Yudong
Published: August 2021

In the current study, based on the national fire statistics from 2003 to 2017, we analyzed the 24-hour occurrence regularity of fire in China to study the occurrence regularity and influencing factors of fire and provide a reference for scientific and effective fire prevention. The results show that the frequency of fire is low from 0 to 6 at night, accounting for about 13.48%, but the death toll due to fire is relatively high, accounting for about 39.90%. Considering the strong seasonal characteristics of the time series of monthly fire frequency, the SARIMA model predicts the fire frequency. According to the characteristics of time series data and prediction results, an optimized Seasonal Autoregressive Integrated Moving Average Model (SARIMA) model based on Quantile outlier detection method and similar mean interpolation method is proposed, and finally, the optimal model is constructed as SARIMA (1,1,1) (1,1,1) 12 for prediction. The results show that: according to the optimized SARIMA model to predict the number of fires in 2018 and 2019, the root mean square error of the fitting results is 2826.93, which is less than that of the SARIMA model, indicating that the improved SARIMA model has a better fitting effect. The accuracy of the results is increased by 11.5%. These findings verified that the optimized SARIMA model is an effective improvement for the series with quantile outliers, and it is more suitable for the data prediction with seasonal characteristics. The research results can better mine the law of fire aggregation and provide theoretical support for fire prevention and control work of the fire department.
Intranasal type I interferon treatment is beneficial only when administered before clinical signs onset in the SARS-CoV-2 hamster model
Authors: Bessière Pierre , Wasniewski Marine , Picard-Meyer Evelyne , Servat Alexandre , Figueroa Thomas , Foret-Lucas Charlotte , Coggon Amelia , Lesellier Sandrine , Boué Frank , Cebron Nathan , Gausserès Blandine , Trumel Catherine , Foucras Gilles , Salguero Francisco J. , Monchatre-Leroy Elodie , Volmer Romain
Published: August 2021

Impaired type I interferons (IFNs) production or signaling have been associated with severe COVID-19, further promoting the evaluation of recombinant type I IFNs as therapeutics against SARS-CoV-2 infection. In the Syrian hamster model, we show that intranasal administration of IFN-α starting one day pre-infection or one day post-infection limited weight loss and decreased viral lung titers. By contrast, intranasal administration of IFN-α starting at the onset of symptoms three days post-infection had no impact on the clinical course of SARS-CoV-2 infection. Our results provide evidence that early type I IFN treatment is beneficial, while late interventions are ineffective, although not associated with signs of enhanced disease.
Cuban history of CRF19 recombinant subtype of HIV-1
Authors: Zhukova Anna , Voznica Jakub , Dávila Felipe Miraine , To Thu-Hien , Pérez Lissette , Martínez Yenisleidys , Pintos Yanet , Méndez Melissa , Gascuel Olivier , Kouri Vivian
Published: August 2021

CRF19 is a recombinant form of HIV-1 subtypes D, A1 and G, which was first sampled in Cuba in 1999, but was already present there in 1980s. CRF19 was reported almost uniquely in Cuba, where it accounts for ∼25% of new HIV-positive patients and causes rapid progression to AIDS (∼3 years).

We analyzed a large data set comprising ∼350polandenvsequences sampled in Cuba over the last 15 years and ∼350 from Los Alamos database. This data set contained both CRF19 (∼315), and A1, D and G sequences. We performed and combined analyses for the three A1, G and D regions, using fast maximum likelihood approaches, including: (1) phylogeny reconstruction, (2) spatio-temporal analysis of the virus spread, and ancestral character reconstruction for (3) transmission mode and (4) drug resistance mutations (DRMs). We verified these results with a Bayesian approach. This allowed us to acquire new insights on the CRF19 origin and transmission patterns. We showed that CRF19 recombined between 1966 and 1977, most likely in Cuban community stationed in Congo region. We further investigated CRF19 spread on the Cuban province level, and discovered that the epidemic started in 1970s, most probably in Villa Clara, that it was at first carried by heterosexual transmissions, and then quickly spread in the 1980swithin the “men having sex with men” (MSM) community, with multiple transmissions back to heterosexuals. The analysis of the transmission patterns of common DRMs found very few resistance transmission clusters.

Our results show a very early introduction of CRF19 in Cuba, which could explain its local epidemiological success. Ignited by a major founder event, the epidemic then followed a similar pattern as other subtypes and CRFs in Cuba. The reason for the short time to AIDS remains to be understood and requires specific surveillance, in Cuba and elsewhere.
NAD+ pool depletion as a signal for the Rex regulon involved in Streptococcus agalactiae virulence
Authors: Franza Thierry , Rogstam Annika , Thiyagarajan Saravanamuthu , Sullivan Matthew J. , Derré-Bobillot Aurelie , Bauer Mikael C. , Goh Kelvin G. K. , Da Cunha Violette , Glaser Philippe , Logan Derek T. , Ulett Glen C. , von Wachenfeldt Claes , Gaudu Philippe
Published: August 2021

In many Gram-positive bacteria, the redox-sensing transcriptional repressor Rex controls central carbon and energy metabolism by sensing the intra cellular balance between the reduced and oxidized forms of nicotinamide adenine dinucleotide; the NADH/NAD+ratio. Here, we report high-resolution crystal structures and characterization of a Rex ortholog (Gbs1167) in the opportunistic pathogen,Streptococcus agalactiae, also known as group B streptococcus (GBS). We present structures of Rex bound to NAD+and to a DNA operator which are the first structures of a Rex-family member from a pathogenic bacterium. The structures reveal the molecular basis of DNA binding and the conformation alterations between the free NAD+complex and DNA-bound form of Rex. Transcriptomic analysis revealed that GBS Rex controls not only central metabolism, but also expression of the monocistronicrexgene as well as virulence gene expression. Rex enhances GBS virulence after disseminated infection in mice. Mechanistically, NAD+stabilizes Rex as a repressor in the absence of NADH. However, GBS Rex is unique compared to Rex regulators previously characterized because of its sensing mechanism: we show that it primarily responds to NAD+levels (or growth rate) rather than to the NADH/NAD+ratio. These results indicate that Rex plays a key role in GBS pathogenicity by modulating virulence factor gene expression and carbon metabolism to harvest nutrients from the host.
Modern Acinetobacter baumannii clinical isolates replicate inside spacious vacuoles and egress from macrophages
Authors: Sycz Gabriela , Di Venanzio Gisela , Distel Jesus S. , Sartorio Mariana G. , Le Nguyen-Hung , Scott Nichollas E. , Beatty Wandy L. , Feldman Mario F.
Published: August 2021

Multidrug-resistant Acinetobacter baumannii infections are increasing at alarming rates. Therefore, novel antibiotic-sparing treatments to combat these A. baumannii infections are urgently needed. The development of these interventions would benefit from a better understanding of this bacterium’s pathobiology, which remains poorly understood. A. baumannii is regarded as an extracellular opportunistic pathogen. However, research on Acinetobacter has largely focused on common lab strains, such as ATCC 19606, that have been isolated several decades ago. These strains exhibit reduced virulence when compared to recently isolated clinical strains. In this work, we demonstrate that, unlike ATCC 19606, several modern A. baumannii clinical isolates, including the recent clinical urinary isolate UPAB1, persist and replicate inside macrophages within spacious vacuoles. We show that intracellular replication of UPAB1 is dependent on a functional type I secretion system (T1SS) and pAB5, a large conjugative plasmid that controls the expression of several chromosomally-encoded genes. Finally, we show that UPAB1 escapes from the infected macrophages by a lytic process. To our knowledge, this is the first report of intracellular growth and replication of A. baumannii. We suggest that intracellular replication within macrophages may contribute to evasion of the immune response, dissemination, and antibiotic tolerance of A. baumannii.
Relation between Renal Resistive Index and Serum Albumin in Nephrotic Syndrome
Authors: Dey Pranoy , Hage Niku
Published: August 2021

BACKGROUND Renal resistive index (RRI) is a non-invasive marker of renal function, which can be measured by renal USG Doppler. High RI indicates poor prognosis, which has been associated with conditions such as proteinuria, hypertension, chronic kidney disease and renal failure. As nephrotic syndrome is characterised by significant proteinuria and hypoalbuminemia, which may progress to renal failure, it is important to see the correlation of RRI with serum albumin level. The purpose of this study was to assess the relation between renal resistive index and serum albumin in nephrotic syndrome. METHODS USG renal Doppler was done for all the children with nephrotic syndrome and RRI was calculated as [(peak - systolic velocity − end - diastolic velocity) / peak - systolic velocity]. Blood investigations were also done, from which serum albumin values were obtained. RRI was compared with mean serum albumin level. Statistical analysis of data was performed using the computer programme, Statistical Package for Social Sciences (SPSS for windows, version 21.01, Chicago, SPSS Inc.) and Microsoft excel 2010. Results on continuous measurement were presented as mean ± standard deviation and compared using Analysis of Variance (ANOVA). RESULTS The mean serum albumin in the children with nephrotic syndrome in our study was 1.82 ± 0.32 gm / dl. The mean RI value was 0.66 ± 0.14 SD, 0.64 ± 0.15 SD and 0.66 ± 0.12 SD as well as 0.63 ± 0.12 SD, 0.67 ± 0.16 SD and 0.71 ± 0.13 SD on the right and left kidney respectively for each of upper, middle, and lower pole. P value of left kidney and right kidney was 0.0057 and 0.6409 respectively. CONCLUSIONS Lower the mean serum albumin level, higher the range of RRI. KEY WORDS Serum Albumin, Renal Resistive Index, Nephrotic Syndrome, USG Renal Doppler
Attitude and Practices of Health Care Professionals and Their Family Members toward Health Care Professionals Dealing with Covid-19 Patients in New Delhi, India
Authors: Chopra Shruti , Gujral Sabreen , Sood Shweta , Sharma Naresh , Singh Akshara
Published: August 2021

BACKGROUND Coronavirus was noticed in the mid-1930’s and the first case of infection in humans was reported as a cold in 1960. In December 2019, clusters of pneumonia cases caused havoc in China. In order to eliminate the infection in the current pandemic, World Health Organisation (WHO) has furnished several recommendations, online courses, and training sessions to increase knowledge, prevention, and control among the health care workers (HCWs). It is crucial to guarantee the safety of not only the health care professionals but also the people who are in close contact with them. We wanted to assess the attitude and safety practices of family members of health care professionals dealing with Covid-19 patients and if the increasing number of cases in India have altered their reaction. METHODS A cross-sectional survey-based study was conducted from July - August 2020 on HCWs dealing with Covid-19 patients and any close contact personnel such as family members of HCWs in order to avoid the spread of Covid-19 among individuals aged 14 - 60 years. RESULTS A total of 368 respondents participated in the study. Majority of the respondents had a positive attitude. In terms of relation, children had a negative attitude towards having their family member deal with Covid-19 patients (46.2 %; N = 46) whereas, 51.5 % (N = 35) spouses had a more positive outlook and 49.2 % (N = 181) respondents reported that the increasing cases in India had altered their initial reaction. CONCLUSIONS Majority of the participants from our study reported a positive attitude towards a family member working in close contact with a Covid-19 patient. More than 50 % of the participants had undertaken various precautions to restrict the spread of the disease. KEY WORDS Health Personnel, Infectious Disease Transmission, Pandemic, Preventive Practices, Relatives
Association of Type of Splint, Rationale for Splinting and Survival of Splint, Based on Different Clinical Scenarios with Long Term Follow Up in Chennai Population
Authors: Narayan Siddharth , Malaiappan Sankari
Published: August 2021

BACKGROUND The revival of older treatment modalities like splinting requires the assessment of newer patient centric parameters like survival, compliance, anaesthetics apart from changing the biomaterials employed alone. The purpose of this study was to assess the association between type of splint, chief complaint and survival of splint based on different clinical scenarios with long term follow-up. METHODS The present study was a prospective university based clinical trial with convenience sampling to include clinical scenarios which required splinting in a Chennai Dental College. Ninety-five adult patients were included in the study comprising 50 men and 45 women, aged between 19 - 65 years where parameters like demographic distribution, type of splint, location of the splint, patient compliance and survival were included. The primary end point of the present study was recall of patients periodically every month till 6 - 8 months to assess the duration of survival of splints and associate the same with age, gender, patient compliance, type of splint and rationale for splinting. RESULTS Among the 95 patients included (524 teeth splinted together), all patients completed the treatment protocol, stainless steel wire composite splints were given to 70 patients while composite mesh splints were used in 20 patients. A likelihood ratio of 0.024 (P < 0.05) was seen while associating composite mesh splints, rationale for use, survival time and patient compliance. CONCLUSIONS Within the limits of the present study, a conclusion was made that one must emphasise on the importance of retaining natural teeth based on appropriate clinical scenarios where maximum benefit could be obtained among compliant patients. KEY WORDS Periodontal Splints, Survival Rate, Patient Compliance, Rationale for Splinting, Tooth Fractures, Tooth Reimplantation
Diabetes and Periodontitis – A Socioeconomic Disease?
Authors: Palwankar Pooja , Tandon Shourya , Blaggana Vikram , Palwankar Drishti , Sachdeva Akshat
Published: August 2021

Periodontitis is a chronic inflammation of periodontal tissues. It is a slow progressing infectious disease. Periodontitis is recognized as the sixth complication of diabetes. Periodontitis and diabetes are chronic diseases. It has a bilateral relationship with diabetes mellitus. Socioeconomic status encompasses income, educational status of head of the family, and family occupation. To upgrade and assess the knowledge concerning the association of periodontitis with diabetes and socioeconomic status, conclusions derived from the case - control studies, epidemiological studies and cross-sectional studies indexed in PubMed / Medline, Scopus journals during the period of 2010 – 2020 were analysed. This article elucidates 1) Whether there is a relationship between periodontitis and diabetes and vice-versa? 2) Association between periodontitis and socioeconomic status? 3) Relationship between socioeconomic status, diabetes, and periodontitis? After a thorough evaluation of the literature, it was found that there is a link between diabetes with periodontitis and vice-versa, socioeconomic status with periodontitis and diabetes, and thus there is a direct association of periodontitis with diabetes and socioeconomic status. Diabetes and socioeconomic status are the prime risk factors of periodontitis. The education and motivation regarding periodontal health in all socioeconomic groups, pre-diabetes, and diabetics with periodontitis in the population would yield a better oral health quality of life. With the changes in socioeconomic status scale in each year, the need for reviewing the association between periodontitis, diabetes, and socioeconomic status in India becomes imperative. KEY WORDS SES - Socioeconomic Status, IDDM - Insulin - Dependent Diabetes Mellitus, NIDDM - Non - Insulin - Dependent Diabetes Mellitus, IL - 6 - Interleukin - 6, IL - 1β - Interleukin 1 Beta, TNFα - Tumour Necrosis Factor Alpha
Surgical Management of an Open Apex with Platelet-Rich Fibrin and Hydroxyapatite Bone Graft – A Case Report
Authors: R. Rajakeerthi , M. S. Nivedhitha , S. Madhumita , Chakravarthy Dhanavel
Published: August 2021

Periapical surgery is the treatment of choice for a large periapical lesion with bone loss that occurs due to long standing untreated teeth affected by trauma, caries or in situations where there is an endodontic treatment failure. Failure of nonsurgical endodontic treatment may be due to peri radicular tissues incorporating with infections, foreign body response to filling materials, over instrumentation or over obturation which might have prevented complete periapical healing. We present here 2 case reports wherein, combination of platelet-rich fibrin (PRF) and the hydroxyapatite (HA) graft was used to achieve rapid healing of large periapical lesions, and the treatment outcome concluded that PRF and hydroxyapatite bone graft accelerated the wound healing and induced the rapid rate of bone formation, which was confirmed radiographically. Untreated non-vital teeth generally result in bone destruction in periapical region, which may occur due to the spread of infection following pulpal necrosis, trauma or failed endodontic treatment. Surgical intervention is essential when endodontic treatment has failed and retreatment is not possible. Periapical surgery, Apicoectomy or root end resection endodontic surgery is a safe and well documented treatment alternative when teeth with periapical pathosis are not responding to conventional endodontic treatment.1 Periapical surgery removes periapical pathosis resulting in optimal wound healing with regeneration of the bone and periodontal tissue.
Psicólogo hospitalar: desafios e possibilidades do manejo frente ao paciente oncológico diante do contexto de pandemia (Covid-19) / Hospital psychologist: challenges and management possibilities in the face of cancer patients in the context of a pandemic context (Covid-19)
Authors: Oliveira Cleide de Jesus Oliveira e , Mora Emily Silva , Silva Eduardo Barbosa da , Silva Tailane Mendes da , Azevedo Caroline Almeida de
Published: August 2021

Resumo: Este estudo tem como objetivo geral revisar na literatura quais são os desafios e possibilidades do manejo do psicólogo hospitalar frente ao paciente oncológico diante do contexto de pandemia (Covid-19). Realizado através de uma revisão integrativa, através da seleção de artigos nas seguintes bases de dados: PubMed, BVS e BVSCC, ao qual através de critérios de seleção foram escolhidos 06 artigos para compor a base de informações para análise e discussão acerca a temática abordada. Como resultados principais verificou-se que é de grande relevância o manejo da psicologia hospitalar no apoio e conscientização da importância da continuidade do tratamento e no trato de doenças do quadro psíquico destes pacientes. Conclui-se neste estudo que frente a realidade de pandemia em magnitude global é verificado consequências severas no abandono dos tratamentos oncológicos, a psicologia utilizando o manejo tecnológico da suporte ao paciente para o enfrentamento de casos, ajudando  o paciente oncológico desde o processo de negação da doença a aceitação, fatores que afetam o tratamento da parte biológica, dificultando a melhora do quadro clinico.
Elevação de Margem Cervical na Reabilitação de Dentes Posteriores: Revisão de Literatura / Cervical Margin Elevation in Posterior Teeth Rehabilitation: Literature review
Authors: Santos Filho Altemar De Carvalho , De Araujo Yasmin Soares , Lessa Ângela Guimarães
Published: August 2021

A cárie interproximal representa grande desafio aos Cirurgiões-Dentistas. Uma situação clínica muito comum é a restauração em dentes posteriores com cárie interproximal que estende abaixo da junção cemento-esmalte. Tendo objetivo de realizar uma revisão de literatura sobre elevação de margem cervical em dentição posterior, abordando os principais critérios do tratamento. Este é um estudo descritivo e qualitativo, analisando a literatura científica, a partir de trabalhos publicados e em bases de dados, que aborda a elevação da margem cervical. Com a falta da estrutura do esmalte, presença de concavidades radiculares e interferência do tecido gengival, o profissional deve ter conhecimento para restaurar caixas proximais profundas. É indispensável o respeito da integridade do periodonto, gerando uma dificuldade na realização do método restaurativo de acordo os padrões ideais. Concluímos que a técnica é um procedimento com etapas e critérios que devem ser seguidos para que não haja complicações.
Visita Domiciliar do Enfermeiro na Estratégia Saúde da Família: Sob o Olhar do Idoso / Nurses' Home Visit in the Family Health Strategy: From the Perspective of the Elderly
Authors: Batista Gismária Bezerra , Almeida Lucas Araújo , Limeira Clélia Patrícia Da Silva
Published: August 2021

Resumo: O envelhecimento da sociedade brasileira vem acontecendo de forma bem acelerada nos últimos tempos. As transformações na estrutura etária no Brasil incidiram dentre os anos 1940 e 1960, no qual a nação presenciou uma redução expressiva da mortalidade, conservando a fecundidade em níveis elevados. O aumento da expectativa de vida, na realidade, é uma conquista de qualquer nação. O estudo tem por objetivo principal identificar as percepções dos idosos em relação à visita domiciliar realizada pelo enfermeiro da atenção básica de saúde. O estudo foi desenvolvido através de uma pesquisa de campo, com recursos e procedimentos metodológicos qualitativos, por meio do uso dos instrumentos e técnicas: questionário e observação, no qual entrevistamos 10 idosos, durante o período de novembro de 2020 a dezembro de 2020. Como resultado o estudo, foi possível mostrar a importância da oferta do enfermeiro no cuidar em saúde ao idoso no âmbito familiar de forma a garantir ao usuário uma atenção qualificada. Como desafios foi possível identificar as dificuldades frente às ações desenvolvidas na Visita Domiciliar que precisam ser realizadas em caráter continuado de forma a garantir a melhoria da qualidade de vida da pessoa idosa e acompanhar suas demandas em família. Pode-se concluir que é necessário repensar as práticas das equipes de Atenção Básica para que a visita domiciliar seja vista como possibilidade para que ações de promoção da saúde sejam implementadas. E que apesar dos avanços ainda existe amplos desafios a serem superados para a oferta de uma assistência humanizada fundada no acolhimento domiciliar.
Previsão Orçamentária X Arrecadação do ISSQN em municípios da mesorregião de Alta Floresta – MT / Budget Forecast X Collection of ISSQN in municipalities of the Alta Floresta mesoregion – MT
Authors: Friske Hadassa Landherr , Jesus Geisiely Dosso Karnoski de
Published: August 2021

A pesquisa procurou analisar a previsão orçamentária e a arrecadação dos municípios de Alta Floresta, Apiacas e Nova Monte Verde entre os anos de 2015 e 2020, apresentando conceitos e dados tabulados a fim de verificar a efetividade da previsão orçada pelas referidas cidades. Adotou, o método de pesquisa descritiva com caráter quantitativo, utilizando-se de dados secundários e pesquisas documentais e bibliográficas empregando um corte longitudinal de 5 anos. Os dados foram obtidos pelo Portal da Transparência de cada município e evidenciam, de modo geral que, houve oscilações nos valores orçados e arrecadados, porém que os municípios vêm aprimorando o processo no decorrer dos últimos anos e apresentaram resultados mais próximos ao ideal, a equivalência de valores.
O Papel das Universidades na Construcão de um Modelo Educacional Pós- Pandemia / The Role of Universities in Building Post-Pandemic Educational Model
Authors: Ribeiro Rafael De Oliveira , Sousa Felipe Neris Torres de
Published: August 2021

Resumo: Com o surgimento da Covid 19 e o rápido contágio pelo mundo todo, muitos foram os problemas e os desafios que surgiram a partir de então. Com a Educação, os impactos foram sentidos imediatamente e a necessidade de se reinventar os modelos educacionais para que pudessem ser dados aos alunos as condições mínimas de ensino sem que os impactos fossem ainda maiores do que já estavam sendo. Daí em diante, muito se teve que aprender e se adaptar, mais já se está conseguindo superar essa fase. Agora, se faz necessário pensar em um modelo de educação que se adapte as necessidades dessa sociedade que sairá da pandemia com uma visão diferente da educação da que tinha anteriormente. Assim, temos como objetivos desse estudo a COVID 19 e seus efeitos, de maneira a inserir no ambiente educacional e demonstrando o porquê que as Universidades são o ambiente capaz de conduzir e construir o modelo ideal de educação no pós-pandemia o qual vá de encontro com as necessidades do momento.
Análise temporal de descarte de bolsas de sangue por sorologia positiva no Hemonúcleo de Redenção – HENRE – (Pará) de 2010 a 2017
Authors: Rodrigues Carla Andreia Resende , Martins Anna Clara Resende , da Silva Diego Pereira , Sagica Fernanda do Espirito Santo , De Oliveira Edivaldo Herculano Correa
Published: August 2021

A portaria nº 1.353/2011 estabelece aos serviços hemoterápicos o alcance de altos padrões de qualidade, critérios na produção, serviços, cuidados com o indivíduo e ambiente. Baseando-se nisso, o presente estudo teve como objetivo investigar e analisar os indicadores de desqualificação das bolsas de sangue por sorologia positiva, em um hemocentro de Redenção (PA). Para isso, foi feito uma compilação de descartes por HIV, HTLV, Hepatite B e C, Doenças de Chagas, Sífilis a partir de dados obtidos através de relatórios institucionais referentes a descartes de bolsas de sangue total. Como resultado, observou-se que do total de 25.169 candidatos à doação, 1.609 bolsas coletadas foram descartadas por sorologia positiva: 1219 Hepatite B (anti-HBs), 56 Hepatite B (HBsAG), 135 Sífilis, 60 HCV, 50 Doença de Chagas, 48 HTLV e 49 HIV. O descarte das bolsas desqualificadas seguiu as normativas preconizadas pelos órgãos competentes. Dessa forma, conclui-se que os resultados observados nessa instituição atenderam a perspectiva de identificar e analisar as causas e os processos de descartes de bolsas de sangue por sorologia reativa. Espera-se a pesquisa norteie ações no controle dessas doenças, aprimore a identificação de doadores inaptos e resulte no aumento da segurança transfusional, na redução de descarte de bolsas e na atenção aos riscos sanitários e ambientais dos serviços de hemoterapia.
Avaliação do acompanhamento clínico de recém-nascidos pré-termo egressos da Unidade de Terapia Intensiva Neonatal de um Hospital Universitário no Sul do Brasil
Authors: Strelow Fonseca Nara Cristine , Arrieira Rafael de Oliveira , de Barros Fernando Celso Lopes Fernandes , Portelinha Márcia Kaster
Published: August 2021

Avaliar o tipo de agendamento recebido por recém-nascidos pré-termo egressos da Unidade de Terapia Intensiva Neonatal de um Hospital Universitário em Pelotas-RS A coleta de dados obteve informações sobre a atenção hospitalar, características clínicas do recém-nascido e sociodemográficas da mãe a partir de prontuários médicos e de entrevista com os familiares. Após a alta, o acompanhamento consistiu em uma ligação telefônica em 15, 30, 45, 60, 75 e 90 dias, ocorrendo durante junho e dezembro de 2019. Nas ligações, os familiares eram questionados sobre tipo de leite ofertado ao bebê e o local de acompanhamento médico. O estudo identificou que, no momento da alta, somente 53% dos recém-nascidos receberam agendamento, e este ao Ambulatório de pediatria da Faculdade de Medicina, enquanto os demais foram apenas encaminhados. Não houve agendamento para o Ambulatório de seguimento (follow-up). A média de peso ao nascer foi menor e o tempo de internação foi maior entre aqueles que tiveram consulta agendada. Conclui-se que a utilização do Ambulatório de seguimento necessita rever seus protocolos de oferta e agendamento, pois não contempla a demanda exigida. Sugere-se incentivo e informação aos familiares, para que façam uso deste serviço e aos profissionais de saúde, para que o referenciem.
Constructing 3D geological models based on large-scale geological maps
Authors: Wu Xuechao , Liu Gang , Weng Zhengping , Tian Yiping , Zhang Zhiting , Li Yang , Chen Genshen
Published: August 2021

The construction of 3D geological models based on geological maps is a subject worthy of study. The construction of geological interfaces is the key process of 3D geological modeling. It is hard to build the bottom interfaces of quaternary strata only using boundaries in large-scale geological maps. Moreover, it is impossible to construct bedrock geological interfaces through sparse occurrence data in large-scale geological maps. To address the above-mentioned two difficulties, we integrated two key algorithms into a new 3D modeling workflow. The buffer algorithm was used to construct virtual thickness contours of quaternary strata. The Inverse Distance Weighted (IDW) algorithm was applied to occurrence interpolation. Using a regional geological map of a city in southern China, the effectiveness of our workflow was verified. The complex spatial geometry of quaternary bottom interfaces was described in detail through boundaries buffer. The extension trends of bedrock geological interfaces were reasonably constraint by occurrence interpolation. The 3D geological model constructed by our workflow accords with the semantic relationship of tectonics. Through the model, the complex spatial structure of urban shallow strata can be displayed stereoscopically. It can provide auxiliary basis for decision-making of urban underground engineering.
Parvovirus B19 associated autoantibodies upregulation in women and children in Southern China
Authors: Yu Qing , Tan Ruhong , Zhao Jiayi , Zhou Qixian , Zheng Fen , Li Xiangxin
Published: August 2021

Objectives

Human parvovirus B19, the cause of fifth disease in children and transient arthropathy in adults, could induce autoimmunity and the production of autoantibodies. The aim of this study is to explore the relationship between B19 infection and autoantibodies upregulation in women and children.

Methods

Of 512 women and children in our hospital between 2016 and 2018, all cases simultaneously test anti-B19 IgM and autoantibodies like anti-nuclear antibody, anti-Sm and anti-double stranded DNA antibody were included in this study.

Results

Parvovirus B19 infection could significantly upregulate anti-nuclear antibody and anti-Sm, but not anti-double stranded DNA, the titer of autoantibodies is associated with the content of anti-B19 IgM, and the infection in children is accompanied with more obvious autoantibodies upregulation.

Conclusions

Our data shows that parvovirus B19 infection is related to autoantibodies production in both women and children, and the status of infection may associate with the titer of autoantibodies in parvovirus B19 infected patients.
Assessment of SARS-CoV-2 rapid antigen tests
Authors: Özcürümez Mustafa , Katsounas Antonios , Holdenrieder Stefan , von Meyer Alexander , Renz Harald , Wölfel Roman
Published: August 2021

Objectives

Point-of-care antigen tests (PoC-AgTs) for the rapid detection of SARS-CoV-2 infection enable screening of additional populations with less effort, independent of laboratories and at a low cost. PoC-AgTs have therefore been included in national testing strategies with additional quality requirements to address limitations in specificity and sensitivity. Information given in the package inserts of the test providers should enable the user to evaluate the performance of a PoC-AgT in advance. The quality of this information has been independently assessed since the Corona Test Ordinance came into force in Germany in October 2020.

Methods

The completeness of analytical and diagnostic performance specifications was assessed for all package inserts publicly available via the Paul Ehrlich Institute (PEI). It was ascertained whether the minimum criteria, recommendations, and extended criteria of the PEI were comprehensibly fulfilled. The number of tests removed from the list by March 2021 was determined.

Results

By the closing date of the survey (17.11.2020), the PEI had listed 165 PoC-AgTs that formally fulfilled the minimum criteria and were thus reimbursed. A total of 78 identical systems were identified. Almost all providers were found to have gaps in the information on the validation results of their tests, meaning that an evaluation of performance is only possible to a limited extent. Until March 2021, 25 non-identical PoC-AgTs have been removed from the list.

Conclusions

Many PoC-AgTs could not be comprehensively evaluated based on the information provided by the provider. Users are therefore dependent on provider-independent sources of information.