bluuebunny/crossref_metadata_2025 huggingface dataset:
Sustainable Workplace Mental Well Being for Sustainable SMEs: How?
Authors: Cinar Ayse Basak , Bilodeau Stephane
Published: April 2022

Sustainable mental health and wellbeing (MHW), as addressed under SDG3, is crucial for achieving sustainable development, notably for sustainable SMEs growth. MWH is specifically interlinked with SDGs 8, 9 and 11: Economic growth and prosperity, sustainable communities, innovation, and jobs. Studies show over 200 million workdays are lost due to poor MHW each year, referring to the global cost of $1 trillion/year in lost productivity and it is increasing every year. Poor workplace MWH is almost an epidemic after COVID-19. It will be a significant challenge for a long time, in particular for SMEs which are hit hardest by the pandemic, as MHW problems have been shown to be a COVID side effect among 1:5 people. Despite the multifactorial aetiology of MHW (individual, social, environmental, and organizational), interventions for workplace MHW mostly refer to ‘one size fits all’ and top-down solutions, primarily asking for the commitment and behaviour change of employees; that has shown to be ineffective. The main assumption underlying the present work is the need for a proactive and tailored MHW frameworks that can be blended to organizational policies. The objective which corresponds to the main purpose of the paper is to provide a 5-staged MWH model, stemming from our evidence-based studies, that may speak for the identified need. We also discuss how the Model can provide a route map on how SMEs can implement and measure SDGs relevant to their business in synergistic interaction with SDG3.
Cultural and Creative Industries and Copyright at the Regional Level: The Cases of Shenzhen and Hangzhou in China
Authors: Zhang Ya-Feng
Published: April 2022

Cultural creative industries (CCIs) have become an important driver in motivating the modern economy around the world, and the sustainable development of CCI is calling for a proper profit mechanism. Using China as the research context, this article investigates how copyright is used in the development of CCIs. The cities of Shenzhen and Hangzhou are selected as cases, and I identify 98 representative CCI enterprises from Shenzhen and 127 representative CCI enterprises from Hangzhou to conduct the analysis. It is found that the development of CCIs in different cities shows different models with regional characteristics, and shares some characteristics in common; most CCI enterprises have experience with copyright registration; copyright is highly correlated with other types of intellectual property (e.g., patent, trademark), and there is an obvious integration of copyright and technology; judicial lawsuits have become a major tool for enterprises to use copyright to protect their benefits, with plaintiffs winning the majority of the lawsuits. This research has both significant theoretical and practical implications, and contributes to theory about the use of copyright in the development of CCI at a regional level.
Barriers and Motives for Physical Activity and Sports Practice among Trans People: A Systematic Review
Authors: Oliveira Joana , Frontini Roberta , Jacinto Miguel , Antunes Raúl
Published: April 2022

This study aimed to analyze the research conducted between 2016 and 2021, regarding barriers and motives for the practice of physical activity (PA), physical exercise (PE), and sports among trans individuals. The searches were carried out in the PubMed, Scopus, and Web of Science databases between January 2022 and April 2022, and included papers published between October 2016 and December 2021. After reading the full text of the studies, and according to the eligibility criteria previously defined, only six studies met the inclusion criteria. Internal barriers were related to body dissatisfaction and discomfort, discrimination, and fear of other people’s reactions. Regarding external barriers, sports environment, PE environment, and sports participation policies and regulations are the main factors expressed by trans individuals that hinder the practice of sports and PE. The desire to achieve a specific physical form and the role that PE plays in the preparation and/or replacement of gender-confirming surgery are the most important motives for the practice. This study highlights the importance of continuing to fight the barriers encountered in the practice of PE and sports, suggesting the main motives that could help create better interventions, plans, and inclusive policies that may help promote its practice.
Dynamics of Environmental Conservation Agriculture (ECA) Utilization among Fujioka Farmers in Japan with High Biodiversity Conservation Awareness but Low ECA Interest
Authors: Maharjan Keshav Lall , Gonzalvo Clarisse , Aala Wilson
Published: April 2022

Japan aims to be carbon-neutral by 2050 by targeting various sectors including agriculture. One of the main strategies in this sector to mitigate climate change effects is environmental conservation agriculture (ECA); however, ECA utilization remains low in most of Japan’s prefectures to this date. To address this problem and to know what factors influence ECA adoption, we collected data from Fujioka city, Gunma prefecture, which has low ECA utilization but has high biodiversity conservation efforts. Using factor analysis and binary logistic regression, two major themes emerged by which ECA continuation can be increased, namely: farmers’ intent to improve their local/global environment and to enhance their production. The study highlighted the importance of ECA information dissemination as evidenced by the presence of a knowledge gap on how ECA translates into climate change advocacies. The promotion of farmer-consumer market channels and extension of ECA products in local industries by government and non-government institutions are also recommended to strengthen rural-urban linkages in the area. Increasing the ECA uptake of farmers would also have a positive impact on the ongoing preservation of endangered yaritanago fish species in Fujioka. Lastly, the results from this study highlight the heterogeneity of factors that affect any given farming community with respect to the strategies that can effectively drive ECA adoption.
Invariant Interpolation Space for Generalized Multivariate Birkhoff Interpolation
Authors: Cui Kai , Jiang Xue
Published: April 2022

In this paper, we provide a detailed exposition of a generalized multivariate Birkhoff interpolation scheme (Z,S,E) and introduce the notions of invariant interpolation space and singular interpolation space. We prove that the space PS, which is spanned by the monomial sequence S, is invariant or singular if the incidence matrix E satisfies some conditions. The advantage of our results lie in the fact that we can deduce whether PS is always proper or not for all choices of the given node set Z, just from the property of the incidence matrix E, with very low computational complexity.
Spare Parts Transportation Optimization Considering Supportability Based on Uncertainty Theory
Authors: Yang Yi , Gu Jiaying , Huang Siyu , Wen Meilin , Qin Yong , Liu Wei , Guo Linhan
Published: April 2022

Ensuring a consistent, continuous, and efficient spare parts supply is a critical issue that must be addressed in the equipment support system. In order to effectively improve the coverage level and handle the common asymmetry information present in practical applications, the spare parts transport vehicle routing and scheduling model was further optimized. We integrated supportability requirements and uncertainty theory into the model to better describe the actual uncertain demand of each site. We selected three critical supportability indicators as constraints, redefined them with uncertain variables, and then completed the chance-constrained model on this basis. Once the confidence level is specified, the uncertain constraints can be transformed into deterministic constraints, and finally, the equivalent deterministic model can be solved easily. In addition, a feasible solution can be found through a genetic algorithm, and a numerical example is provided to validate the model’s rationality. The proposed method successfully seeks the balance between the total cost and supportability.
Research on the Residual Bearing Capacity of a Rib Beam Bridge Carriageway Slab Based on Fatigue Cumulative Damage
Authors: Wu Yuxuan , Yu Tianlai , Zhang Linlin , Wang Yifan , Chen Binglin
Published: April 2022

In order to study the residual bearing capacity of the carriageway slab of a reinforced concrete rib beam bridge after fatigue damage, a double T-beam carriageway slab model with a high degree of symmetry was designed and fatigue tests were carried out. Based on the fatigue cumulative damage theory, the fatigue residual strength equation of concrete was improved and a constitutive fatigue model of a steel bar and concrete with arbitrary loading times was established. Because the carriageway slabs are highly symmetrical, we used a ratio of length to width and a ratio of width to height to express the dimensional changes in the carriageway slabs. Abaqus general analysis program was used to create a symmetrical T-beams model and analyze the influence of the fatigue load level, the ratio of width to height of the roadway slab, and the ratio of length to width on the remaining bearing capacity of the roadway slab. Finally, the 1stOpt fitting software was employed to fit the roadway slab’s residual bearing capacity evaluation model. The fatigue test results show that the fatigue failure form of the roadway slab is punching failure, and the development law of fatigue damage can be divided into three stages, accounting for 6.25%, 56.25%, and 37.5% of the total fatigue life. The finite element analysis results showed that the length–width ratio of the roadway slab is positively correlated with its relative residual bearing capacity, and the residual bearing capacity of the two-way slab is higher than that of the one-way slab. The fatigue load level and the aspect ratio of width to height are negatively correlated with their relative residual bearing capacity.
New Formulations on Kinetic Energy and Acceleration Energies in Applied Mechanics of Systems
Authors: Negrean Iuliu , Crișan Adina , Șerdean Florina , Vlase Sorin
Published: April 2022

Multibody mechanical systems (i.e., serial, and parallel robots) have a wide range of applications in the industrial field. In technological processes, these systems perform mechanical movements, in which the active forces have a certain time variation law and, hence, induce higher-order accelerations in the mechanical system, which become central functions in acceleration energies. The advanced dynamics study of multibody systems, often characterized by symmetry, is conducted by applying the differential and variational principles. Lagrange–Euler equations and their time derivatives are commonly used. Here, the central function is the kinetic energy and its higher-order time derivatives. Additionally, the generalization of Gibbs–Appell equations, where the central function is represented by the first and higher-order acceleration energy, can be applied. This paper aims to establish a relation between the kinetic energy and acceleration energy for different material systems. This purpose is achieved by applying the absolute second-order time derivative on the expressions of kinetic energy, corresponding to different material systems. Following this differential calculation and by applying some constraints, the relationship between kinetic energy and acceleration energy is obtained. For validating the relation between kinetic energy and acceleration energy of the first, second and third order, an application is presented.
Analytical Formulas for Conditional Mixed Moments of Generalized Stochastic Correlation Process
Authors: Duangpan Ampol , Boonklurb Ratinan , Chumpong Kittisak , Sutthimat Phiraphat
Published: April 2022

This paper proposes a simple and novel approach based on solving a partial differential equation (PDE) to establish the concise analytical formulas for a conditional moment and mixed moment of the Jacobi process with constant parameters, accomplished by including random fluctuations with an asymmetric Wiener process and without any knowledge of the transition probability density function. Our idea involves a system with a recurrence differential equation which leads to the PDE by involving an asymmetric matrix. Then, by using Itô’s lemma, all formulas for the Jacobi process with constant parameters as well as time-dependent parameters are extended to the generalized stochastic correlation processes. In addition, their statistical properties are provided in closed forms. Finally, to illustrate applications of the proposed formulas in practice, estimations of parametric methods based on the moments are mentioned, particularly in the method of moments estimators.
Key Challenges to the Effective Management of Pollutants in Water and Sediment
Authors: Jesus Fátima , Tremblay Louis A.
Published: April 2022

The intensification of human activities is placing increasing pressure on the ecosystems of riverine, estuarine, and coastal waters, as these compartments are sinks for many anthropogenic contaminants [...]
Aflatoxin Contamination, Its Impact and Management Strategies: An Updated Review
Authors: Shabeer Saba , Asad Shahzad , Jamal Atif , Ali Akhtar
Published: April 2022

Aflatoxin, a type of mycotoxin, is mostly produced by Aspergillus flavus and Aspergillus parasiticus. It is responsible for the loss of billions of dollars to the world economy, by contaminating different crops such as cotton, groundnut, maize, and chilies, and causing immense effects on the health of humans and animals. More than eighteen different types of aflatoxins have been reported to date, and among them, aflatoxins B1, B2, G1, and G2 are the most prevalent and lethal. Early detection of fungal infection plays a key role in the control of aflatoxin contamination. Therefore, different methods, including culture, chromatographic techniques, and molecular assays, are used to determine aflatoxin contamination in crops and food products. Many countries have set a maximum limit of aflatoxin contamination (2–20 ppb) in their food and agriculture commodities for human or animal consumption, and the use of different methods to combat this menace is essential. Fungal infection mostly takes place during the pre- and post-harvest stage of crops, and most of the methods to control aflatoxin are employed for the latter phase. Studies have shown that if correct measures are adopted during the crop development phase, aflatoxin contamination can be reduced by a significant level. Currently, the use of bio-pesticides is the intervention employed in many countries, whereby atoxigenic strains competitively reduce the burden of toxigenic strains in the field, thereby helping to mitigate this problem. This updated review on aflatoxins sheds light on the sources of contamination, and the on occurrence, impact, detection techniques, and management strategies, with a special emphasis on bio-pesticides to control aflatoxins.
Multidimensional Effectiveness of Botulinum Toxin in Neuropathic Pain: A Systematic Review of Randomized Clinical Trials
Authors: Lippi Lorenzo , de Sire Alessandro , Folli Arianna , D’Abrosca Francesco , Grana Elisa , Baricich Alessio , Carda Stefano , Invernizzi Marco
Published: April 2022

Although botulinum toxin (BoNT) has been suggested as a treatment to counter neuropathic pain, no previous systematic reviews investigated the multidimensional effects of BoNT on pain relief and Health-Related Quality of Life (HR-QoL). The aim of this systematic review is to summarize the current evidence on the effectiveness of BoNT treatment for neuropathic pain, and to characterize its multidimensional effectiveness in order to guide physicians in clinical practice. Five databases were systematically searched up to 4 April 2022, to identify randomized controlled trials satisfying the following criteria: adults suffering from neuropathic pain, BoNT administration, any comparator, multidimensional assessment of pain as primary outcome, HR-QoL, physical function, anxiety and depression, and sleep quality as secondary outcomes. Twelve studies were included. The multidimensional pain scales used were short-form McGill Pain Questionnaire, Neuropathic pain scale, Neuropathic Pain Symptom Inventory, International SCI Pain Basic Data Set, West Haven-Yale Multidimensional Pain Inventory, Brief Pain Inventory, and Douleur Neuropathique 4. These scales highlighted the positive effects of BoNT administration. According to the Jadad scale, all the RCTs included were high-quality studies. BoNT administration might be effectively introduced in the comprehensive management of neuropathic pain. Further research should focus on optimal and cost-effective therapeutic protocols.
Mathematical Modeling Finds Disparate Interferon Production Rates Drive Strain-Specific Immunodynamics during Deadly Influenza Infection
Authors: Ackerman Emily E. , Weaver Jordan J. A. , Shoemaker Jason E.
Published: April 2022

The timing and magnitude of the immune response (i.e., the immunodynamics) associated with the early innate immune response to viral infection display distinct trends across influenza A virus subtypes in vivo. Evidence shows that the timing of the type-I interferon response and the overall magnitude of immune cell infiltration are both correlated with more severe outcomes. However, the mechanisms driving the distinct immunodynamics between infections of different virus strains (strain-specific immunodynamics) remain unclear. Here, computational modeling and strain-specific immunologic data are used to identify the immune interactions that differ in mice infected with low-pathogenic H1N1 or high-pathogenic H5N1 influenza viruses. Computational exploration of free parameters between strains suggests that the production rate of interferon is the major driver of strain-specific immune responses observed in vivo, and points towards the relationship between the viral load and lung epithelial interferon production as the main source of variance between infection outcomes. A greater understanding of the contributors to strain-specific immunodynamics can be utilized in future efforts aimed at treatment development to improve clinical outcomes of high-pathogenic viral strains.
Deletion of the CTRL2 Insulator in HSV-1 Results in the Decreased Expression of Genes Involved in Axonal Transport and Attenuates Reactivation In Vivo
Authors: Singh Pankaj , Collins Matthew F. , Johns Richard N. , Manuel Kayley A. , Ye Ziyun A. , Bloom David C. , Neumann Donna M.
Published: April 2022

HSV-1 is a human pathogen that establishes a lifelong infection in the host. HSV-1 is transported by retrograde axonal transport to sensory neurons in the peripheral nervous system where latent viral genomes can reactivate. The resulting virus travels via anterograde axonal transport to the periphery and can cause clinical disease. CTCF insulators flank the LAT and IE regions of HSV-1 and during latency and maintain the integrity of transcriptional domains through a myriad of functions, including enhancer-blocking or barrier-insulator functions. Importantly, during reactivation, CTCF protein is evicted from the HSV-1 genome, especially from the CTRL2 insulator. CTRL2 is a functional insulator downstream of the 5′exon region of the LAT, so these results suggest that the disruption of this insulator may be required for efficient HSV-1 reactivation. To further explore this, we used a recombinant virus containing a deletion of the CTRL2 insulator (ΔCTRL2) in a rabbit ocular model of HSV-1 infection and induced reactivation. We show that, in the absence of the CTRL2 insulator, HSV-1 established an equivalent latent infection in rabbits, but those rabbits failed to efficiently reactivate from latency. Furthermore, we found a significant decrease in the expression of the gene Us9-, a gene that codes for a type II membrane protein that has been shown to be required for anterograde transport in neurons. Taken together, these results suggest that the functions of the CTRL2 insulator and Us9 activation in reactivating neurons are intrinsically linked through the regulation of a gene responsible for the axonal transport of HSV-1 to the periphery.
Intense Innate Immune Responses and Severe Metabolic Disorders in Chicken Embryonic Visceral Tissues Caused by Infection with Highly Virulent Newcastle Disease Virus Compared to the Avirulent Virus: A Bioinformatics Analysis
Authors: Cheng Shanyu , Liu Xinxin , Mu Jiaqi , Yan Weiwen , Wang Mengjun , Chai Haoran , Sha Yuxin , Jiang Shanshan , Wang Sijie , Ren Yongning , Gao Chao , Ding Zhuang , Stoeger Tobias , Tseren-Ochir Erdene-Ochir , Dodovski Aleksandar , Alfonso Pastor , Mingala Claro N. , Yin Renfu
Published: April 2022

The highly virulent Newcastle disease virus (NDV) isolates typically result in severe systemic pathological changes and high mortality in Newcastle disease (ND) illness, whereas avirulent or low-virulence NDV strains can cause subclinical disease with no morbidity and even asymptomatic infections in birds. However, understanding the host’s innate immune responses to infection with either a highly virulent strain or an avirulent strain, and how this response may contribute to severe pathological damages and even mortality upon infection with the highly virulent strain, remain limited. Therefore, the differences in epigenetic and pathogenesis mechanisms between the highly virulent and avirulent strains were explored, by transcriptional profiling of chicken embryonic visceral tissues (CEVT), infected with either the highly virulent NA-1 strain or the avirulent vaccine LaSota strain using RNA-seq. In our current paper, severe systemic pathological changes and high mortality were only observed in chicken embryos infected with the highly virulent NA-1 strains, although the propagation of viruses exhibited no differences between NA-1 and LaSota. Furthermore, virulent NA-1 infection caused intense innate immune responses and severe metabolic disorders in chicken EVT at 36 h post-infection (hpi), instead of 24 hpi, based on the bioinformatics analysis results for the differentially expressed genes (DEGs) between NA-1 and LaSota groups. Notably, an acute hyperinflammatory response, characterized by upregulated inflammatory cytokines, an uncontrolled host immune defense with dysregulated innate immune response-related signaling pathways, as well as severe metabolic disorders with the reorganization of host–cell metabolism were involved in the host defense response to the CEVT infected with the highly virulent NA-1 strain compared to the avirulent vaccine LaSota strain. Taken together, these results indicate that not only the host’s uncontrolled immune response itself, but also the metabolic disorders with viruses hijacking host cell metabolism, may contribute to the pathogenesis of the highly virulent strain in ovo.
Longitudinal Randomized Cohort Study of SARS-CoV-2 Antibody Seroprevalence in the St. Petersburg Population
Authors: Smirnov Vyacheslav S. , Lyalina Liudmila V. , Milichkina Anzhelika M. , Khamitova Irina V. , Zueva Elena V. , Ivanov Valery A. , Zaguzov Vitaly S. , Totolian Areg A.
Published: April 2022

Introduction. Since the detection of the first COVID-19 patient, 2 years have passed, during which more than 287,862,000 people have fallen ill globally, of which about 1.9% died. The implementation of SARS-CoV-2 control programs required efforts from almost all countries. An important direction in the fight against COVID-19 has been the formation of herd immunity, the main tool for managing the pandemic. Study goal. The aim of the study was to assess the seroprevalence of antibodies (Abs) to SARS-CoV-2 nucleocapsid (Nc) and receptor binding domain (RBD) in the St. Petersburg population during the COVID-19 pandemic. Materials and methods. A longitudinal cohort randomized monitoring study of Ab seroprevalence (SARS-CoV-2 Nc, RBD) was organized and conducted according to a unified methodology developed by Rospotrebnadzor with the participation of the St. Petersburg Pasteur Institute. For this purpose, a cohort was formed of 1000 volunteers who participated in all five stages of seromonitoring. The cohort was divided into seven age groups: 1–17; 18–29; 30–39; 40–49; 50–59; 60–69; 70; and older (70+) years. Seropositivity levels (Nc, RBD) were assessed by quantitative and qualitative enzyme immunoassays. During the second year of monitoring, some volunteers were vaccinated with the GamCOVIDVac (84%) or EpiVacCorona (11.6%) vaccines approved in Russia. Statistical processing was carried out using Excel 2010. Confidence intervals for shares and percentages (95% CI) were calculated using the method of A. Wald and J. Wolfowitz with adjustment (A. Agresti, B.A. Coull). The statistical significance of differences was calculated by z-test, using the appropriate online calculator (p < 0.05) unless indicated. Results. There was a trend toward an increase in Nc seropositivity in stages 1–3 of seromonitoring, with a decrease in stages 4–5 among children and adults. The share of RBD seropositive steadily increased during all five stages of seromonitoring. The most frequent finding was low anti-RBD Abs levels (22.6–220 BAU/mL). High Ab levels were recorded statistically significantly less frequently. Asymptomatic forms were observed in 84–88% of SARS-CoV-2 seropositive volunteers. By the fifth stage of monitoring, this indicator significantly decreased to 69.8% (95% CI: 66.1–73.4). The monitoring revealed a statistically significant increase in anti-RBD Abs alongside a statistically significant decrease in the proportion of Nc seropositives. This dynamic was especially characteristic of persons vaccinated with GamCOVIDVac. Conclusion. Prior to the use of specific vaccines, a seroprevalence of anti-Nc Abs was noted. After the introduction of the GamCOVIDVac vaccine in adults, a decrease in the level of anti-Nc Abs was noted due to an increase in the proportion of RBD seropositive persons.
SARS-CoV-2 Virus-like Particles Produced by a Single Recombinant Baculovirus Generate Anti-S Antibody and Protect against Variant Challenge
Authors: Sullivan Edward , Sung Po-Yu , Wu Weining , Berry Neil , Kempster Sarah , Ferguson Deborah , Almond Neil , Jones Ian M. , Roy Polly
Published: April 2022

Coronavirus Disease 2019 (COVID-19), caused by infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has highlighted the need for the rapid generation of efficient vaccines for emerging disease. Virus-like particles, VLPs, are an established vaccine technology that produces virus-like mimics, based on expression of the structural proteins of a target virus. SARS-CoV-2 is a coronavirus where the basis of VLP formation has been shown to be the co-expression of the spike, membrane and envelope structural proteins. Here we describe the generation of SARS-CoV-2 VLPs by the co-expression of the salient structural proteins in insect cells using the established baculovirus expression system. VLPs were heterologous ~100 nm diameter enveloped particles with a distinct fringe that reacted strongly with SARS-CoV-2 convalescent sera. In a Syrian hamster challenge model, non-adjuvanted VLPs induced neutralizing antibodies to the VLP-associated Wuhan S protein and reduced virus shedding and protected against disease associated weight loss following a virulent challenge with SARS-CoV-2 (B.1.1.7 variant). Immunized animals showed reduced lung pathology and lower challenge virus replication than the non-immunized controls. Our data suggest SARS-CoV-2 VLPs offer an efficient vaccine that mitigates against virus load and prevents severe disease.
Live-Attenuated Oral Vaccines to Reduce Campylobacter Colonization in Poultry
Authors: Jeon Byeonghwa , Saisom Tunchanok , Sasipreeyajan Jiroj , Luangtongkum Taradon
Published: April 2022

The control of Campylobacter in poultry at the pre-harvest level is critical to reducing foodborne infections with Campylobacter since the consumption of contaminated poultry is the most frequent cause of human campylobacteriosis. Although poultry vaccination is suggested as useful intervention measures, no Campylobacter vaccines are currently available. To develop live-attenuated oral Campylobacter vaccines, in this study, we evaluated the efficacy of pre-colonization by oxidative stress defense mutants, including knockout mutants of ahpC, katA, and sodB, in preventing Campylobacter jejuni from colonizing poultry. Interestingly, when chickens were pre-colonized with ΔahpC and ΔkatA mutants, rather than the ΔsodB mutant, the level of C. jejuni colonization was significantly reduced within 35 days. Further studies demonstrated when chickens were pre-colonized with the ΔahpC mutant by oral challenge with a high dose (ca., 5 × 108 CFU/bird) and a low dose (ca., 5 × 106 CFU/bird), it twice reduced the level of C. jejuni by 3.9 log10CFU/g feces and 3 log10CFU/g feces after 42 days, respectively, compared to the untreated control. Due to a colonization defect, the ΔahpC mutant was removed from chickens within 42 days. After excretion from the host, moreover, the ΔahpC mutant cannot survive in aerobic environments because of compromised aerotolerance. Our findings suggest that the ahpC mutant has a great potential for on-farm application to control C. jejuni at the pre-harvest level.
Comparison of Marine Ecosystems of Haizhou Bay and Lvsi Fishing Ground in China Based on the Ecopath Model
Authors: Gao Shike , Chen Ze , Lu Yanan , Li Zhen , Zhang Shuo , Yu Wenwen
Published: April 2022

Recently, under the impacts of environmental shifts and human activities, marine ecosystem conservation and recovery have become increasingly important for the management and sustainable development of fishery resources. We construct two Ecopath models to describe and compare the similarities and differences in the structure and function of the ecosystems in Haizhou Bay (HZB) for 2020–2021 and Lvsi Fishing Ground (LSFG) for 2018–2019 in this study. Our results highlight the similarities of the two ecosystems in which plankton (e.g., zooplankton and phytoplankton) are important functional groups with bottom-up effect control and congers control the top-down effect. The differences between the two ecosystems indicate that the HZB ecosystem is relatively mature due to higher Finn’s cycling index (FCI), Finn’s mean path length (FMPL), Connectance Index (CI), System Omnivory Index (SOI), and Ascendency/capacity (A/C). However the food web structure in the LSFG is more diverse and stable with higher Overhead/capacity (O/C) and Overhead/capacity (H). The differences are possibly due to the low trophic level (TL) species composition in the two ecosystems. Therefore, we suggest that stock enhancement and release methods should be deployed to release high TL species into designated water areas to increase food web complexity and ecosystem maturity in HZB and LSFG. This study will help inform ecosystem and fishery regulations in different ways and facilitate discussion towards the establishment of strategic conservation planning and adaptive management.
Prognostic significance of lymph node yield on oncologic outcomes according to tumor response after preoperative chemoradiotherapy in rectal cancer patients
Authors: Ryu Hyo Seon , Park In Ja , Ahn Bo Kyung , Park Min Young , Kim Min Sung , Kim Young Il , Lim Seok-Byung , Kim Jin Cheon
Published: April 2022

Purpose: This study aimed to evaluate the predictive value of lymph node yield (LNY) for survival outcomes according to tumor response after preoperative chemoradiotherapy (PCRT) in patients with rectal cancer.Methods: This study was a retrospective study conducted in a tertiary center. A total of 1,240 patients with clinical stage II or III rectal cancer who underwent curative resection after PCRT between 2007 and 2016 were included. Patients were categorized into the good response group (tumor regression grade [TRG], 0–1) or poor response group (TRG, 2–3). Propensity score matching was performed for age, sex, and pathologic stage between LNY of ≥12 and LNY of <12 within tumor response group. The primary outcome was 5-year disease-free survival (DFS) and overall survival (OS).Results: LNY and positive lymph nodes were inversely correlated with TRG. In good responders, 5-year DFS and 5-year OS of patients with LNY of <12 were better than those with LNY of ≥12, but there was no statistical significance. In poor responders, the LNY of <12 group had worse survival outcomes than the LNY of ≥12 group, but there was also no statistical significance. LNY of ≥12 was not associated with DFS and OS in multivariate analysis.Conclusion: LNY of <12 showed contrasting outcomes between the good and poor responders in 5-year DFS and OS. LNY of 12 may not imply adequate oncologic surgery or proper staging in rectal cancer patients treated by PCRT. Furthermore, a decrease in LNY should be comprehended differently according to tumor response.
Fatores que influenciam a mulher na escolha de via de parto / Factors that influence women in the choice of birth delivery
Authors: Padua Gabriela Rissonio , Lima Larissa Carolina , Fernandes Mariana Franco , Gandra Angélica Benetaci de Aquino , Polido Carolina Guizardi
Published: April 2022

Ao longo dos anos o parto e assistência ao parto sofreram transformações, saindo das residências e entrando em ambiente hospitalar, tornando-se o parto, então, um evento regrado, transformando a parturiente de sujeito a objeto, tirando sua autonomia. Este trabalho busca analisar através de revisão de literatura os fatores que interferem na escolha da via de parto. Para realização do método foi realizado leitura flutuante dos textos pertinentes ao assunto na Biblioteca Virtual em Saúde entre os anos de 2016 e 2021, que estivessem disponíveis em formato completo, online e gratuito. A questão norteadora deste estudo foi: quais as influências que a mulher pode sofrer para a tomada de decisão acerca de seu parto? Após análise dos textos, foram elencadas 4 principais categorias de interferências: o pré-natal, a própria via de parto, a autonomia da gestante e a influência do enfermeiro. Conclui-se, neste trabalho, que a enfermagem é um dos principais instrumentos de mudança no cenário obstétrico, através da assistência com acolhimento, escuta, instrução e apoio emocional, possibilitando o resgate da autonomia da mulher no processo de parir.
Removal of methylene blue dye from aqueous solution using biomass of Cunninghamella echinulata UCP 1297 as superbiosorbent / Remoção do corante azul de metileno de solução aquosa usando biomassa de Cunninghamella echinulata UCP 1297 como superbiossorvente
Authors: Sobral Daniel de Morais , Montero-Rodríguez Dayana , Silva Ákylla Fernanda Souza , De Souza Adriana Ferreira , Dos Santos Valdemir Alexandre , Campos-Takaki Galba M.
Published: April 2022

Nowadays, water pollution caused by dye contaminants has become a severe global issue and aroused tremendous attention, since it is estimated that more than 100 thousand types of commercial organic dyes have been produced. Meanwhile, huge amounts of dyes have been discharged into natural environment during the production process, which causes serious environmental problems. Hence, it is quite urgent to remove the dyestuffs from water, and several methods have been devoted to resolving this issue, including biosorption processes. In this context, this study aimed the decolorization of methylene blue using biomass of Mucoralean fungi Cunninghamella echinulata UCP 1297, as alternative biosorbent. The fungus C. echinulata was initially cultivated in low-cost medium containing 1% corn steep liquor and 5% mature Pacovan banana (Musa sapientum) peel flour, at pH 6, 28ºC and 150 rpm, during 96 h. Fungal biomass obtained after filtration and centrifugation of cultures was subjected to lyophilization. The biosorbent (lyophilized biomass was sieved to obtain particles of size less than 1.0 mm, which were used for decolorization of methylene blue from aqueous solution at concentration of 5 mg/L. Experiments were carried out for 24 and 48h at 28ºC, using a 23 full-factorial design (FFD) to evaluate the influence of agitation, pH and amount of biosorbent. Discoloration was determined by measuring absorbance at 660 nm in UV-Visible spectrophotometer. According to the results, fungal biomass proved to be an excellent biosorbent of methylene blue, showing the highest percentage of removal (95.407%) and (96.427%) were observed in the condition 8 of the FFD, with the maximum levels of the evaluated variables (200 rpm of agitation, pH 9 and 90 mg of biomass). However, in the condition 4 similar variables, except to biomass (200 rpm of agitation, pH 9 and 10 mg of biomass) showed a lower methylene blue removal as 0.413 and 10.249%, respectively to 24 and 48h of incubation. The results indicated that the amount of Cunninghamella echinulata UCP 1297 biomass influenced the decolorization bioprocess of the methylene blue azo dye, proving to be a superbiosorbent. Thus, this study confirmed the suitability of fungal biomass for dye removal process and the cost-effectiveness of it uses due to inexpensive medium for production using agro-industrial residues.
Acesso das mulheres privadas de liberdade às ações de controle do câncer do colo do útero / Access of women deprived of their freedom to cervical cancer control actions
Authors: Da Silva Elaine Regina Prudencio Hipólito , Cazola Luiza Helena de Oliveira , Barbieri Ana Rita , De Souza Albert Schiaveto
Published: April 2022

Objetivo: Analisar o acesso das mulheres privadas de liberdade às ações de controle do câncer do colo do útero. Método: Estudo transversal, realizado com 349 mulheres na faixa etária de 25 a 64 anos e análise de 230 prontuários. As associações entre as variáveis foram realizadas por meio do teste Qui-quadrado e teste Exato de Fisher, considerando-se 95% de confiabilidade. Resultados: A realização do citopatológico foi referida por 199 (57,0%) mulheres e, em 95 (41,1%) dos prontuários havia registro do procedimento. Nas entrevistas houve associação estatística significativa entre realização do exame e estabelecimentos prisionais sob gestão municipal que aderiram à Política Nacional de Atenção Integral à Saúde das Pessoas Privadas de Liberdade, bem como, entre a realização do exame e o tempo de reclusão (p<0,001). Conclusão: A adesão à política dos estabelecimentos sob gestão municipal representa um elemento facilitador na melhoria da atenção à saúde dessa população.
Aprendizagem colaborativa - abordagem numa perspectiva teórica / Collaborative learning - approach from a theoretical perspective
Authors: Gaspar Maria Ivone Clemente
Published: April 2022

Este texto assume uma perspectiva teórica e tem como objeto a aprendizagem colaborativa. Desenvolve-se em quatro pontos, atribuindo aos três primeiros a preocupação de articular conceitos que criem a base de sustentação de “aprendizagem colaborativa” e o quarto ponto tem a função de registar algumas questões que são sintoma de alguma perplexidade perante este tipo de aprendizagem. Num primeiro ponto, de natureza introdutória, reflete-se sobre o conceito de aprendizagem, visando a sua operacionalização para este estudo, pelo que merece o título de Aprendizagem. Depois, num segundo ponto, analisa-se, sucintamente, o conceito de comunidade no confronto de dois tipos de comunidade – “comunidade de prática” e “comunidade de aprendizagem” -  pelo que aparece com o título de Comunidades. No ponto três, tendo como referente as comunidades de aprendizagem, caracteriza-se a Aprendizagem colaborativa, para, finalmente, surgir um ponto 4, à guisa de conclusão.
As dificuldades do ensino de química no 1º ano do ensino médio em uma escola pública Estadual de Fortaleza: um estudo de caso / The difficulties of teaching chemistry in the 1st year of high school in a public school in Fortaleza: a case study
Authors: De Andrade Jonacir Siqueira , Pordeus Marcel Pereira
Published: April 2022

Este Artigo é uma síntese da minha dissertação de mestrado em Ciências da Educação, realizado na Universidad Interamericana. A pesquisa que será detalhada tem por objetivo identificar quais os fatores responsáveis pelas dificuldades no ensino de Química no 1º ano do Ensino Médio, em uma escola pertencente à rede pública de ensino do estado do Ceará, localizada na cidade de Fortaleza. A busca se justifica em função de constantes notas baixas na disciplina de Química nesta unidade escolar, onde se originou o interesse de pesquisar sobre o ensino ministrado, além da necessidade da Química no Ensino Médio ter de se voltar para a vida e para o trabalho. Na execução deste trabalho, realizou-se uma investigação na referida escola, onde se aplicou um questionário de perguntas abertas para professores, adotando-se a pesquisa qualiquantitativa, de caráter exploratória e estudo de caso. A pesquisa mostrou como resultado que um dos maiores fatores que interferem no ensino de Química é a falta de base em Matemática, o que ocasiona um grande déficit de raciocínio lógico científico. Conclui-se também que existem outros fatores, como os familiares, pois os alunos vêm de famílias de baixa renda, onde os pais não têm uma visão sobre a importância do ensino de Química, nem sobre o verdadeiro papel da escola na educação de seus filhos. Em suma, a pesquisa foi concluída apontando algumas sugestões para o melhoramento do ensino de Química na escola citada, propostas como: maior utilização do laboratório nas atividades experimentais, salas de aula mais adequadas e confortáveis, melhores condições de trabalho para os professores, biblioteca com bons livros, mais investimento do governo no setor de educação, dentre outros. Resta-se balancear a situação e mais do que incentivar os discentes para o ensino superior, deve-se prepará-los para a vida, e isto é possível através da educação, ressaltando-se que a Química poderá contribuir também de maneira fundamental.
Reforço de argamassas com fibras de papel kraft reaproveitadas de embalagens de cimento / Reinforcement of mortars with kraft paper fibers reuse of cement packaging
Authors: Morais Carlos Drumond do Nascimento , Cruz Wilians Montefusco da , Morais Marcelo Victor de Assis , Louzada Rafael Pereira , Mendes Paulo Roberto de Lima
Published: April 2022

Dentre os insumos utilizados na construção civil, o cimento Portland é um dos mais utilizados. A sua embalagem é de difícil reaproveitamento, pois ao entrar em contato com o cimento, torna-se inadequado aos processos convencionais de reciclagem, sendo comumente descartados de forma irregular. A embalagem é feita de papel Kraft, a partir de polpas de fibras celulósicas longas, as quais são utilizadas como materiais de reforços em materiais de construção há muitos anos. O presente trabalho teve como objetivo avaliar o uso de fibras de papel Kraft reaproveitadas de embalagens de cimento como material suplementar na confecção de argamassas. As fibras foram utilizadas com as porcentagens de 0, 0,5, 1 e 1,5% do peso do material seco no traço fixo de 1: 0,48: 3, e avaliadas conforme suas propriedades físicas de índice de vazios, absorção de água e massa específica, e suas propriedades mecânicas de resistência à compressão e à tração. Entre as composições estudadas, o suplemento adicional de 0,5% de fibras papel Kraft nos corpos de prova proporcionou resistências mecânicas semelhantes ao do grupo com 0% de fibras, de modo que o uso das fibras se mostrou um meio adequado para a produção de materiais de construção sustentáveis.
Logística: a importância de integração entre setores e a valorização do professional / Logistics: the importance of integration between sectors and the valorization of the professional
Authors: Farias Vinicius Palmeira , Rosa Adriano Carlos Moraes
Published: April 2022

A Logística é uma ciência que vem sendo utilizada e desenvolvida por gerações, tendo a sua importância notada inicialmente na guerra para táticas militares e que hoje se transferem para empresas de todos os tamanhos e segmentos. Durante o desenvolvimento deste artigo foi abordado como tema principal a Logística Integrada, sua importância para a interligação ou conexão entre setores e a valorização do profissional que trabalha na área. Objetivou-se apresentar esses elementos como “diferencial nas empresas”, assim como, a respectiva utilização das atuais tecnologias e conhecimentos que a área emprega. Estudou-se a origem da logística desde o período militar, sua atual conceituação até o seu desenvolvimento, ou seja, sua expansão que a tornou “integrada” (principalmente sua conexão com as áreas de recursos humanos e tecnologia). No intuito de enriquecer o trabalho, utilizou-se de pesquisas exploratórias bibliográficas e documentais e, por fim, na discussão, foi focado o aspecto humanístico, onde ressalta-se o momento em que avança a situação da pandemia (Covid), cenário onde a logística e pessoas alinhadas podem realmente fazer a diferença.
Fatores associados à não adesão ao tratamento medicamentoso da hipertensão e da diabetes em dois diferentes serviços públicos de saúde / Factors associated with non-adherence to the medicinal treatment of hypertension and diabetes in two different public health services
Authors: Lago Denice Frota do , Silva Lunara Teles , Dewulf Nathalie de Lourdes Souza , Lopes Flavio Marques
Published: April 2022

Identificar os fatores associados a não adesão ao tratamento medicamentoso em indivíduos com hipertensão e/ou diabetes atendidos em diferentes níveis de serviços públicos de saúde. Trata-se de um estudo transversal que entrevistou pacientes atendidos ou na unidade básica de saúde ou no centro especializado. O questionário aplicado é composto por perguntas sobre as características socioeconômicas, epidemiológicas, farmacoterapêuticas, conhecimentos sobre sua doença crônica ao uso dos medicamentos. As análises estatísticas realizadas foram frequência, teste qui-quadrado e a regressão logística. Na população entrevistada, 56% (218) dos participantes apresentaram não adesão ao tratamento medicamentoso. O perfil desses pacientes atendidos em diferentes tipos de serviços públicos de saúde foi semelhante, exceto para os aspectos faixa etária, sexo, escolaridade, restrição alimentar, receber ajudar para lembrar de tomar seus medicamentos e registro de retirada de medicamento. Sendo que na análise multivariada, os fatores associados a não adesão ao tratamento medicamentoso da hipertensão e/ou diabetes nos usuários da Estratégia da Saúde da Família foram baixa escolaridade (OR: 2,401/ p=0,007) e histórico familiar de doenças cardiovasculares (OR: 2,431/ p=0,005). No Centro Especializado esteve associado ao relato de restrição de sal e/ou açúcar na alimentação (OR: 5,012/ p<0,001) e a falta de registro de retirada de medicamentos (OR: 2,883/ p=0,001). A não adesão ao tratamento medicamentoso ainda é um problema de saúde, os fatores associados a isso foram diferentes entre os dois tipos de serviços de atenção à saúde. Enquanto no serviço de atenção primária esteve relacionada aos aspectos de sentimentos e expectativas dos indivíduos, no serviço de atenção especializada foi relacionada ao comportamento, portanto o foco das intervenções para aumento da adesão não será o mesmo.