bluuebunny/crossref_metadata_2025 huggingface dataset:
Legal aspects of the work with request containing medical secrecy of the citizen in the institution carrying out the medical expertise
Authors: Pavlov Aleksandr V.
Published: September 2020

The scope of present research is the civil-law protection of health (medical) confidentiality of the citizen in the activity of the institution, carrying out a medical expertise. Mentioned category is considered in this article in aspects of the work with requests to obtain or provide, without the consent of the citizen, information bound by his medical secrecy. There are proposed algorithms of actions for processing mentioned information. As the ingredient of the topic there are considered rationales for its delivery (assignment). It is widely acknowledged that in the construction of legal norms regulating relations concerning medical confidentiality, one of the main task of the legislator is to maintain a balance between the interests of the participants of legal relations - as holders of intangible benefits and public interests of the society, through the formation of a special legal regimes. By determination of the legalframework of the execution of the medical expertise, the State sets: conditions of the execution of expertise; conditions for the recognition the citizen as disabled; conditions for the establishment of his disability, etc. In the case of the establishment of the incapacity for work, disability, it enables the citizen a certain legal and social status, but at the same time obliges him to undergo periodic medical examinations (checkups) for the possibility of saving or cancel (change) provided benefits that state is normal practice for the social welfare state. In these and other cases, the citizen is supposed to disclose certain information constituting his medical secrecy - both to employees of medical institutions, as well as to the members of the expert committees, the employer (by authorized persons), etc. The right to disclosure ofsuch information without the consent ofthe citizen, as an exception according to the federal law may be afforded to other persons - within the limits set by law.
The availabilities of thermal waters in the Mostovsky district of the Krasnodar krai in a complex system of rehabilitation and medico-social rehabilitation
Authors: Puzin S. N , Shurgaya Marina A. , Memetov S. S , Bogova O. T , Gal I. G
Published: September 2020

Restorative medicine (RM) is based on principles of sanology, concepts of the preservation of human health (valeology) including occupational one. The origins of VM are SPA methods and systems of the restorative treatment (medical rehabilitation) within the framework of the fundamental principle of national health care are the prevention. The main stages of the development of RM are related to studies of regularities of the preservation and restoration of health, investigation of the process of adaptation and natural aging of the body, the elaboration of advanced methods for the premorbid diagnosis and correction of disturbed functional state of the human. In the article there are presented the availabilities of the using of the mineral springs of the Mostovsky district of the Krasnodar region in the system of modern RMfor a wide variety of somatic pathology.
FINANCIAL PROVISION OF RUSSIAN HEALTH CARE FROM THE FEDERAL FUND OF MANDATORY MEDICAL INSURANCE AND THE BUDGETS OF THE SUBJECTS OF THE RUSSIAN FEDERATION
Authors: Goncharov N. G , Boychenko Yu. Ya , Klochkov V. P , Lukyantseva D. V , Moiseenko S. M , Pidde A. L , Pishchita Aleksandr N. , Prosyanik L. D , Preobrazhenskaya M. I , Rakhimova O. Yu
Published: September 2020

The ongoing reform of the national health care impacted significantly on the health care financing system to the population. Especially these changes were reflected in the financing of public health organizations of the Federal Fund of CHI and from budgets of different levels. The article analyzed the financial aspects of providing public health care system in recent years and estimates prospects for the further reform of the Russian health care.
NONINVASIVE METHODS IN THE DIAGNOSIS OF NON-ALCOHOLIC FATTY LIVER DISEASE
Authors: Bakulin Igor G. , Abatsieva M. P
Published: September 2020

Non-alcoholic fatty liver disease (NAFLD) being increasingly diagnosed worldwide is considered as the most common liver disease in Western countries. The incidence is growing rapidly due to the continuing epidemic of the obesity and diabetes mellitus type 2. There is the extremely topical question of the affordable, effective and early diagnosis of NAFLD. Over the past few years, significant progress has been made in the understanding of its risk factors, pathogenesis, clinical course, methods of diagnosis and treatment of NAFLD. The article gives an overview of modern and promising methods for diagnosing NAFLD, useful for physicians of various specialties who have to deal with NAFLD patients. Key problems of diagnostics are formulated and directions for further research are determined. There is discussed the role of biomarkers as promising noninvasive diagnostic methods, that provides to assess the severity of necrotic inflammatory processes and liver fibrosis in NAFLD patients.
ORGANIZATIONAL APPROACHES TO REHABILITATION OF PATIENTS WITH BENIGN NEOPLASMAS OF THE GYNECOLOGICAL SPHERE IN SANATORIC CONDITIONS
Authors: Tsivyan Boris L.
Published: September 2020

The article discusses the issues of providing rehabilitation care in sanatorium-and-spa facilities to patients with benign neoplasms of the gynecological sphere. The importance of this issue is caused by the high percentage of physiological and psychological disorders occurring in patients of this group in the period of postoperative recovery. In the course of the study, there was executed the assessment of the effectiveness of the organization of sanatorium-and-spa care for patients with benign neoplasms of the gynecological sphere on the example of the experience of a foreign sanatorium-and-spa institution. The study was carried out from the position of the study of the medical documentation of this center, as well as the opinion of patients regarding the provision of assistance in these institutions. It was important that every fourth patient who underwent treatment in a sanatorium-resort environment was a woman of a rather young age, of from 31 to 45 years. Climatic therapy and physiotherapy exercises were carried out in all cases of sanatorium treatment of patients with diseases of this group. Such methods of the treatment as psychotherapy, manual therapy and physiotherapy were popular. Based on the results of rehabilitation in a sanatorium and SPA establishment, in almost all cases, a number of important issues is being resolved, such as maintaining working capacity, social integration into society, preventing of possible violations of functions and preventing and reducing the degree of possible disability, maintaining functions in the process of the current pathological condition. It is important that all the interviewed patients are generally satisfied with the treatment provided to them, while 93.7% of them are completely satisfied and 6.3% indicated that «yes, they are more satisfied».
ASSESSMENT OF EFFICIENCY OF PROGRAMS OF COMPREHENSIVE PREVENTION OF HIV-INFECTION FROM THE POINT OF VIEW OF THE PREVENTION OF LOSS OF YEARS, CUSTOMIZED FOR DISABILITY
Authors: Barinova Anna N.
Published: September 2020

Purpose of the study. To evaluate the efficiency of the prevention programs aimed at the prevention of the spread of HIV infection, represent the it in disabled adjusted life years (DALY) and compare the efficiency with the prevention and treatment costs. Material and methods. Results of the panel study executed in 2006-2013 in 10 regions of Russian Federation in HIV infection risk groups (4 waves). The total number of include participants accounted of 9891. The study protocol included the detailed survey for the risk behavior and HIV testing. The obtained results of the study were used to calibrate the dynamic (Markov) model of the effect of the prevention on the length of the quality-adjusted life and treatment cost. The cost of the prevention was estimated on the base of reporting documents of prevention programs. Results. Programs of the comprehensive prevention of HIV-infection, among injecting drug users give rise in the significant decrease in the HIV incidence. The evaluation of the effect of prevention in frameworks of a multidimensional model shows odds ratio to be of 0.56 (95% CI = 0.40-0.78). This relative reduction of the incidence corresponds to the absolute incidence decrease from 3.98 per 100 person-years, among those not participating in prevention programs (95% CI: 3.37-4.69) to 2.22 per 100 person-years (95% CI: 1.89-2.62) among participants. This effect of the prevention leads to averting losses of 0.75-1.1 DALY per person, with most savings from the diminishing of the disability. In most plausible scenario this results in cost saving with return on the investment of 40 kopeks per rouble invested in prevention. Conclusion. Comprehensive programs of HIV prevention in Russian Federation possess of the significant effectiveness and under plausible assumptions are cost-saving. When discussing financing preventive measures they should be evaluated on real effectiveness and cost.
BIOCONTROL AND PAIN DISORDERS
Authors: Puzin M. N , Kiparisova E. S , Khozhenko E. V , Lepaev Yu. V , Denishchuk I. S , Afanas’ev B. G , Dymochka Mikhail A. , Shtelle A. A , Prokof’ev A. S , Tarasova L. A
Published: September 2020

A man is a complex biological and psychological phenomenon comprised of different behavioral patterns. Just these behavioral patterns cause the development of many diseases. In the article different types of pain disorders are reported, especially in the field of neurostomatology. One of the most interesting trends of behavioral medicine is a method of computer selfregulation based on a universal principle of a biological feedback (BOS is a Russian abbreviation). A method of biological feedback (BOS) and its variations have been proposed for the treatment of pain disorders such as headaches, especially tension-type headache, migraine, associated with depressive states, temporomandibular disorder, burning syndrome etc. There have been described different types of BOS - trainings - relied upon the temperature, EMG, EEG, the influence on frontal muscle groups and other effective trainings - influence on the pain for its healing with the direct participation of the patient. BOS-trainings have been presented in the article as one from dominated methods in contemporary neurostomatology based on universal means of fight against pain - biological self-regulation.
ORGANIZATIONAL AND LEGAL PECULIARITIES OF MEDICINAL PROVISION OF DISABLED PEOPLE IN THE RUSSIAN FEDERATION
Authors: Puzin S. N , Grechko A. V , Pryanikov I. V , Malichenko Vladislav S.
Published: September 2020

Current demographic situation, characterized by a change in the structure of the morbidity rate and rapid aging of the population, has led to an increase in the number of disabled people in the world. Existing international legal norms, activities of international organizations and non-governmental organizations (NGOs), as well as the implemented state policy are not fully able to overcome restrictions on the realization of the rights of disable persons, especially with regard to access to essential medicines. The article analyzes the system of the drug provision organization for disabled people in the Russian Federation, formulates recommendations on the systematization of approaches to the organization of this process with a view to improving the effectiveness of medical and social rehabilitation of disabled people
EXPERIENCE IN IMPROVING TRAINING OF ENGINEERING MEDICAL STAFF ON THE BASIS OF INTRODUCTION OF SCIENTIFIC AND PRACTICAL INTERDISCIPLINARY RESEARCH IN THE EDUCATIONAL PROCESS
Authors: Puzin Sergey N. , Fetisov G. P
Published: September 2020

There is presented the example of the basic department of the Moscow Aviation Institute (National Research University) as the experience of the training engineering personnel for medicine. Measures are proposed to improve the quality of master’s training.
ISSUES OF MEDICAL AND SOCIAL EXPERTISE AND REHABILITATION OF DISABLED PEOPLE IN THE PREPARATION OF BACHELORS OF SOCIAL WORK
Authors: Martynenko A. V , Vorobtsova E. S , Ovchinnikova S. V
Published: September 2020

We analyzed stages of the establishment and development of medical and social workers training, the system of medical and social education in the Russian Federation. We presented the experience of the A.I. Yevdokimov Moscow State University of Medicine and Dentistry in the training the Bachelors of Social Work for the professional engagement in the institutions of the medical and social expertise and rehabilitation area. We examined the purpose, objectives and subject matter of the educational subjects as well as educational technologies used for this purpose.
A NEW MODEL OF MEDICAL REHABILITATION OF PATIENTS FOLLOWING ENDOPROSTHETIC HIP REPLACEMENT IN THE CLINICS OF THE SAMARA STATE MEDICAL UNIVERSITY
Authors: Kotelnikov G. P , Yashkov A. V , Borinskiy Stanislav Yu.
Published: September 2020

The study is devoted to the evaluation of the effectiveness of the new organizational model of medical rehabilitation in patients after the endoprosthetic hip replacement in conditions of the Samara State Medical University clinics.There were observed 348 patients underwent total endoprosthesis of the hip joint due to degenerative-dystrophic processes. In the comparison group consisted of 179 patients, the traditional approaches to re-rehabilitation remained. In the main group of 169 patients, a problem-oriented multidisciplinary approach was implemented, using the International Classification of Functioning (ICF) clinical scales to execute timely examination and route patients to medical organizations. Within the framework of the Pilot Project, for the patients of the main group there were worked out the stage-by-stage approach, continuity, consistency of received medical measures in specialized licensed medical rehabilitation clinics of the Ministry of Health of the Samara Region. There was executed the evaluation of immediate, remote results of clinical and functional parameters of patients after hip joint prosthetics within the framework of the Pilot Project. To evaluate the rehabilitation potential and prognosis, a clinical, laboratory, functional and biomechanical assessment of the patients’ condition was carried out based on radiography, rheovasography, electromyography, podography, thermography, psycho-logical testing, and scale analysis. The analysis of the effectiveness of the new organizational model of medical rehabilitation in patients after hip arthroplasty in conditions of Clinics of the Samara State Medical University is presented.
MORBIDITY IN THE REPUBLIC OF SOUTH OSSETIA FOR THE PERIOD FROM 2012 TO 2016 (GENERAL ASPECTS)
Authors: Puzin S. N , Gal I. G , Totchiev G. F , Amerkhanov Eduard N. , Dmitrieva N. V
Published: September 2020

The article presents the main indices of the morbidity - the general prevalence and incidence in the Republic of South Ossetia over the period from 2012 to 2016 for the main classes, groups and specific types of diseases, as well as for individual socio-demographic groups: the population over 18 years and children aged up to 18 years. Statistical data of the total incidence for 2012-2015 in The Republic of South Ossetia is considered in comparison with similar indices of the Russian Federation. The material reflecting the ranking of incidence rates per 100 thousand of the population is presented. The analysis of the morbidity, the study of statistical indices of the morbidity, both general prevalence, and incidence, as well as the dynamics over the period of 2012-2016, are the key reference points for the development of a corresponding resource for the emerging national health system of the Republic of South Ossetia. This is of particular interest in the implementation of the integration in cooperation between the Republic of South Ossetia and the Russian Federation.
ANALYSIS OF LETHAL OUTCOMES AMONG CHILDREN WITH ETHANOL IN BLOOD SAMPLES
Authors: Klevno Vladimir А. , Maksimov A. V
Published: September 2020

Cases of consumption of alcoholic beverages by children and adolescents are rare. Children’s bodies are considered to be much less resistant to toxic effects of alcohol. However, there are described cases of the non-lethal ethanol poisoning in children when its blood concentration exceeded 5 g/L. The aim of the study. The forensic medical evaluation of the toxic action of ethanol in children depending on age, blood concentration of alcohol taking into account causes of death. Material. Data from statistical reporting, the Bureau of forensic medical examination for the Moscow region over the period of 2003-2017. Results. In lethal outcomes of children the prevalence rate of a positive result of the forensic chemical test of blood for the presence of ethyl alcohol was 1:6. Detected ethanol concentration in corpse blood would correspond to clinical manifestations of intoxication, from mild to severe. Conclusion. Children, whose blood alcohol content formally met the criterion of severe intoxication or alcohol poisoning, can take actions.
THE ROLE OF ANTICHOLINERGIC PROPERTIES OF DRUGS IN THE DEVELOPMENT OF FALLS IN PATIENTS OF SENILE AGE
Authors: Ilina Ekaterina S. , Bordovsky S. P , Polshina N. I , Nikulin V. E , Gorbotenkova S. V , Bogova O. T , Ivanova T. A , Lyalina I. V , Sychev D. A
Published: September 2020

The article presents own results of the effect of anticholinergic properties of drugs on the development of falls in senile cardiovascular disease (CVD) patients under conditions of polypharmacy. The total anticholinergic load was calculated according to the ACBS scale (Anticholinergic Cognitive Burden Scale). Our study showed the ACB scale to be convenient and allows us to identify designations of dangerous drugs that can disrupt cognitive abilities in CVD patients of older age groups, leading to a fall.
Graham-Little-Piccardi-Lassueur syndrome
Authors: Mesnyankina Olga A. , Yanchevskaya E. Yu , Volik A. P , Dumchenko V. V , Butyrina E. V
Published: September 2020

A clinical case of Graham-Little-Piccardi-Lassueur syndrome characterized by combination of follicular keratotic rash (lichen ruberfollicularis) with a cicatricial alopecia on the scalp and non-cicatricial hair loss of the pubis and axillae is presented in the article. In spite of considerable prevalence of genetic and non genetic lichenoid dermatoses Graham-Little-Piccardi-Lassueur syndrome presents certain difficulties and requires careful attention of clinicians.
Hydradenitis suppurativa: etiology, pathogenesis and treatment
Authors: Masyukova S. A , Mordovtseva V. V , Ilina Inna V. , Sanakoeva E. G , Alieva Z. A , Grebenyuk D. V , Sokolova Yu. P
Published: September 2020

Hydradenitis suppurativa is a multifactorial disease. The pathogenesis has not been well studied yet. The views about antecedence of lesions of structural elements of the skin are disputable and that is what determines the actuality of scientific studies in this field. The article presents literature review on modern data regarding prevalence and etiology of the disease. The classification of clinical features and Satorius score for quantitating the severity of the disease, the methods of diagnosis (bacteriological, immunopathological and etc.) are suggested. The role of the genetic, comorbid factors, metabolic and hormonal disorders and the immune system part in the development of the disease are discussed. Topical and systemic medications with the primary purpose of reducing bacterial load, elimination offollicular occlusion, normalization of immune response, correction of hormonal status, improvement of skin defects healing, pain syndrome removal, improving the quality of life ofpatients, are suggested for the therapy.
The idiopathic form of Sweet's syndrome
Authors: Olisova O. Yu , Grabovskaya O. V , Teplyuk N. P , Grekova Ekaterina V. , Ignatieva K. V
Published: September 2020

A clinical case of Sweet’s syndrome (dermatosis neutrophilica febrilis acuta) in a 59-year old man is presented. The data about etiology, pathogenesis and clinical picture are summarized. Difficulties in diagnosis of the disease are described. Sweet’s syndrome is characterized by skin lesions with marked neutrophilic infiltration. The syndrome manifests itself as a rash ofpainful red papules, plaxes, intradermal nodes on the head, neck and hands, multiple ostiofolliculitis. It is also characterized by fever, leukocytosis, arthralgias, episcleritis. Approximately 15% of cases are paraneoplastic. Patergiya can be seen in patients. It is a skin condition, characterized by lesions due to minor injuries. Diagnosis is based on a combination of clinical, physical, laboratory examinations and histological changes. The differential diagnosis should be made with exudative erythema multiforme, allergic vasculitis, erythema elevatum diutinum and erythema nodosum.
Diagnostic algorithm for psoriatic arthritis in clinical practice of dermatologist
Authors: Chamurlieva Maria N. , Korotaeva T. V , Loginova E. Yu , Batkaev E. A
Published: September 2020

The study was carried out in 103 patients with psoriasis, who had the consultation of dermatologist and rheumatologist. Answers for 6 questions mPEST (Psoriasis Epydemiology Screening Tool) modified questionnaire were estimated, each positive answer corresponded to 1, PEST ≥ 3 was suggested the presence of psoriatic arthritis (PsA), PEST < 3 was considered the absence of PsA. All the patients were examined by rheumatologist, the gold standard was CASPAR (ClASsification criteria for Psoriatic Arthritis) criteria. If necessary the instrumental tests were performed: roentgenography, ultrasound examination, magnetic resonance imaging (MRI) and laboratory tests. At PEST ≥ 3 diagnosis of PsA was suspected in 60 (58.2%) of 103 patients. Diagnosis of PsA was confirmed by CASPAR criteria in 47 (45.6%) patients. mPEST less than 3 was in 43 (41.7%) of 103 patients. Diagnosis of PsA was absent by CASPAR criteria in 29 (67.4%) patients. Newly diagnosed PsA was in 32 (52.4%) of 61 patients. Any rheumatic disease, mainly PsA, can develop with psoriasis. mPEST questionnaire in most cases reveals PsA in early stage, however, its isolated use is insufficient to establish an accurate diagnosis, it requires a clear diagnostic algorithm of the disease, including consultation of rheumatologist, clinical and instrumental examination.
Rationale for the treatment of dermatoses algorithm based on patient questionnaires
Authors: Vislobokov Andrey V. , Khmelnitsky R. A
Published: September 2020

The interest in questionnaire methods in medicine is driven by the desire to find approaches to the assessment of the patient’s condition, allowing you to get the comprehensive view about the patient's attitude to prescribed therapy. Goal. To study the trust ofpatients with cutaneous pathology in the various methods and means of therapy depending on disease duration. Materials and methods. The study involved patients with different time course of dermatosis (less than 1 month; from 2 to 6 months from 6 to 24 months more than 24 months) divided into groups of 50 people each and 65 healthy people. All respondents voluntarily completed the questionnaire including questions about the credibility of therapeutic agents that are not drugs, and consent to use traditional and non-traditional methods and means of treatment. Results. The questionnaire found that if the dermatosis exists more than 1 month, then 100% of patients agree to use any means of treatment. A positive attitude to alternative methods of treatment increases over time of the disease, where the rank coefficient of correlation shows a direct correlation. Critical point of the flow of dermatoses, causing patients to look for any alternative methods of treatment is the period of time from 2 to 6 months. The level of patient's confidence to medication has remained consistently high and does not depend on the stages of the disease. Conclusion. Questionnaire method is simple and informative, it allows us to evaluate the patients opinion about the therapy and acceptable to develop algorithm of treatment of dermatological patients.
Stevens-Johnson syndrome
Authors: Olisova O. Yu , Grabovskaya O. V , Teplyuk N. P , Lepekhova A. A , Ignatiev D. V , Ignatieva Kseniya V.
Published: September 2020

The literature review of the epidemiology, etiology and pathogenesis, clinical presentation and diagnosis of the syndrome of Stevens-Johnson severe life-threatening disease characterized by extensive lesions of the skin and mucous membranes, fever and bone and muscle aches, often induced by medication is presented. A review on the methods of treatment and prevention of this disease is presented. The clinical case of patient with the syndrome of Stevens-Johnson is described. The successful treatment of Syndrome Stevens-Johnson with high-dose systemic glucocorticoids was performed.
Differential diagnosis between acrokeratosis verruciformis of Hopf and hypertrophic lichen planus
Authors: Molochkov V. A , Molochkova Yulia V. , Bobrov M. A
Published: September 2020

The article is devoted to the differential diagnosis of hypertrophic form of lichen planus (CPL) with acrokeratosis verruciformis of Hopf (AVH). It is very rare hyperkeratotic genodermatosis usually inherited in an autosomal dominant manner. Due to the marked clinical similarity of these two dermatoses crucial for the correct diagnosis is histological study of the lesion with the identification of histological feature unique for AVH - papillomatosis as a “church steeples”. Two clinical cases diagnosed last year in the department of dermatology and dermatooncology in Moscow regional research and clinical institute are described in the article. The effectiveness of the treatment AVH with acitretin was described.
High-frequency therapy of primary axillary hyperhidrosis
Authors: Pinson I. Ya , Olisova Olga Yu. , Verkhoglyad I. V
Published: September 2020

The article is devoted to a new method of treatment ofprimary axillary hyperhidrosis UHF technology. Anatomy, topography and function of the sweat glands, as well as the mechanism of action of ultrahigh-frequency therapy electromagnetic field frequency from 30 to 300 MHz (wavelength of 10 m to 1 m) in continuous or pulsed mode are described. The aim of the study was to investigate the efficacy and safety of UHF-therapy apparatus SweatX at axillary hyperhidrosis. Inclusion criteria was hyperhidrosis corresponding to the scale of gravity HDSS (Hyperhidrosis Disease Severity Scale) 3 rd and 4 th degree: before treatment in 8 patients HDSS level was equal to 4, in 12 patients - 3. Each patient received a series 4 treatments with an interval of 1 week. Underarm pictures with iodine-starch test subjects was performed at baseline and after 1, 3 and 6 months after the last treatment. Each procedure SweatX exposure consisted of two stages. The total processing time of each axilla was 8-10 minutes (about 20 minutes on both armpits). In the study, as well as between the procedures and follow-up visits were observed no undesirable side effects. After 6 months of follow up indicators HDSS sweating on a scale from 11 (55%) patients dropped to 2, and 9 (45%) patients -1. Thus, on the basis of SweatX use of UHF technology provides a safe, effective and lasting solution to the problems encountered in patients with primary hyperhidrosis underarm.
Syphilitic a multiple giant aortic aneurysm
Authors: Novoselov Victor S. , Kvizhinadze G. N , Tumanova E. L , Belousov S. R , Smirnova L. M
Published: September 2020

In recent years there has been growth in the number of clinical manifestations of late forms of syphilis with damage to the cardiovascular system. This fact makes it necessary to conduct a careful examination of patients with aortic aneurysms and similar lesions of the cardiovascular system. The article gives an overview of modern literature of giant syphilitic aortic aneurysms. The clinical case of multiple syphilitic aneurysm with compression of nearby organs, revealed in vivo is described. The data of instrumental, histopathology, immunohistochemical methods of investigation and the operation are presented.
Expression of protein p27 in various forms of seborrheic keratosis
Authors: Aleksandrova Alexandra K. , Sukolin G. I , Smolynnikova V. A
Published: September 2020

The significant role in the pathogenesis of seborrheic keratosis (SK) plays the violation of the cell cycle regulation. According to the research unit the cell proliferation in acanthotic and irritated histological types of SK is regulated by p27 (Kip1), cyclin-dependent kinase inhibitor. Considering the variety of histological types of SK, definition of p27 expression will reveal the characteristic features of the cell cycle disorders and proliferation for each type of tumor. Material and Methods. Of the 102 tumors from patients with SK, according to the results of histological examination, were selected 10 specimens of each histological types of SK: acanthotic, hyperkeratotic, adenoid, irritated, and clonal. We assessed all specimens for p27 (Kip1) expression using immunohistochemistry (monoclonal antibody p27 at a dilution of 1:20 (Novocastra Laboratories Ltd.). Three skin biopsy samples of healthy individuals were included. Results. Severe diffuse nuclear expression of p27 was present in all cases of adenoid, irritated, and 4 cases of clonal histological types of SK. In other tumor types positive reaction with monoclonal antibody to p27 was reduced as compared with healthy skin were recorded single positively stained nuclei of basal cells. Conclusions. Thus, we have found a violation of p27 protein expression in all types of seborrheic keratosis as with the excess (adenoid, irritated, clonal SK type) and in p27 protein deficiency (acanthotic, hyperkeratotic) normal course of cell cycle phases is broken. This leads to the disappearance of control over the cell proliferative activity and apoptosis, facilitating a slow, uncontrolled growth of SK cells.
Study of the effect of menopausal hormone therapy in women with psoriasis type 2 in postmenopause
Authors: Opruzhenkova Evgeniya P. , Sidorenko O. A , Anisimova L. A , Starostenko V. V
Published: September 2020

The results of comparative analysis of the hormonal status from 75 women aged from 49 to 60 years old (average age 54.04 ± 1.28 year) in postmenopause with psoriasis type 2 (study group) and 50 women of control group of the same age and menstrual status without psoriasis are presented. There were two subgroups in the main group: subgroup 1 received basic therapy in combination with menopausal hormone therapy (MHT) (estradiol 1 mg + drospirenone 2 mg), subgroup 2 - basic therapy. Psoriatic process was assessed according to PASI index and was evaluated by the dermatology quality of the life index (DIQL) and the content of gonadotropic and sex hormones before treatment and after 3 and 6 months of starting treatment in patients of both subgroups. More pronounced clinical efficacy in combination with reduced FSH level is 13.2% (p < 0.001), increased content of estradiol 69.3% (p < 0.001) was observed in patients from 1 subgroup. MHT supplement to the basic treatment decreased the PASI index after 3 months of starting treatment for 50.9% (p fter 6 months - at 94% (p < 0.001), and reduced DIQL in subgroup 1 compared to 2 subgroup after 3 months - 15.3% (p < 0.05) and after 6 months - 20.8% (p < 0.05). In postmenopausal women with psoriasis favorable changes of indexes reflecting the clinical manifestations of the disease were associated with the correction of hormonal status in MHT estradiol 1 mg + drospirenone 2 mg.
Biorevitalizant with multitargeted action
Authors: Lipova E. V , Suhovei Y. G , Griazeva N. V
Published: September 2020

Biorevitalization is an intradermal injection of unstabilized hyaluronic acid to improve skin texture. The article presents the results of the drug Revi for the treatment of rosacea and biological aging by stimulating its internal physiological reserves and it can be recommended in conditions such as rosacea, the biological aging of the skin.
Modern external therapy moderately severe forms of rosacea
Authors: Olisova O. Yu , Kochergin N. G , Smirnova Elena A.
Published: September 2020

The scientific review of modern approaches to the etiology and pathophysiology of rosacea is presented. The features of the disease, importance and possibility of reducing or eliminating the symptoms of the disease for the patient and the doctor in the early stages are shown. The various sources highlighted the frequent and specific, common and rare species of clinical picture of the disease are analyzed. Specific and differentiating symptoms are presented. The “steroid rosacea”, the reasons for occurrence, the difficulty faced by the doctor during the treatment and the possibility of torpid course are described. There was a contradiction of researcher’s views about approaches to the etiology, pathogenesis of the disease and the experimental data. The classification of the rosacea forms, drugs and therapy of moderately severe forms of rosacea are presented. The new topical drugs for the treatment of this disease are described. Results on the methods of topical treatment of moderate forms of rosacea, the results of several double-blind, placebo-controlled studies in the US and Canada, the effectiveness of treatment of rosacea with modern drugs (ivermectin, brimonidine) compared to traditional (in particular, with azelaic acid) are presented. In conclusion high effectiveness, good tolerability and safety of drugs ivermectin (Soolantra) and brimonidine (Mirvaso® Derm) (Galderma, Switzerland) are shown. It is suggested to include the above-mentioned drugs to the Russian standards of treatment of moderately severe forms of rosacea.
Interactions between the immune system disorders and intestinal microbios in patients with pityriasis versicolor
Authors: Makhsudov Maruf R. , Mamatkulov U. A
Published: September 2020

The immune system depending on the degree of intestinal microbiocenosis disorders in patients with pityriasis versicolor was investigated. Patients with pityriasis versicolor have an immune system disorder, which is expressed by a decrease in the activity of cellular immune system and enhancement of humoral one. In addition, in most cases of the pityriasis versicolor there are disbiotic changes, that contribute to the long-term course of the disease and are difficult to treat. The different changes in the immune system depending on the severity of intestinal disbiotic changes in patients with pityriasis versicolor were shown. It was revealed that in patients with pityriasis versicolor changes in the immune system are in direct proportion to the severity of disbiosis. It is appropriate to take into account these changes in the selection of treatment strategy ofpatients with pityriasis versicolor.
Unactivated platelet leukocyte autoplasma in the treatment of non scarring alopecia
Authors: Ragimov G. A , Olisova O. Yu , Egorova Kseniya G.
Published: September 2020

The literature review of the cellular functioning mechanisms of the hair follicles, the role of stem cells in the life cycle of the hair, the major effects of growth factors are presented. Authors, patented treatment method of non scarring alopecia is described. The technology ofpreparation and method of use of unactivated platelet leukocyte autoplasma in various forms of alopecia are described. Own clinical observation of 60 patients with non scarring alopecia and results of their unactivated platelet leukocyte autoplasma are presented. 80% of patients had a clinical cure. Investigations of platelet concentration, white blood cells and growth factors in platelet-rich plasma and platelet leukocyte unactivated autoplasma were performed. The results are shown in the article.
Phagedenic ulcer of the chancre in young woman
Authors: Olisov A. O , Vladimirov V. V
Published: September 2020

The literature data on such severe and rare complications of chancre in primary syphilis as gangrene and phagedenic ulcer, that developing normally in the background of immunodeficiency patients, especially in alcoholics, are presented. Infection and the development of chancre significantly change the clinical manifestations of primary syphilis, which can lead to diagnostic errors. The clinical observation of the patient suffering from alcoholism, which had a diagnosis ofprimary syphilis chancre on the basis of complicated phagedenic ulcer, regional lymphadenitis, positive serological reactions, acute reaction to the beginning of specific treatment, is presented. The treatment with Benzylpenicillin sodium was performed and led to the scarring of the chancre.
Lipidotransport system in patients with acne conglobata forms
Authors: Sliva E. I , Vilova Ksenia Gennadievna , Kashutin S. L , Danilov S. I , Klyuchareva S. V , Piryatinskaya V. A
Published: September 2020

The lipidotransport system at conglobate acne as more severe form that characterized by pronounced hyperplasic and hypertrophic processes in sebaceous gland was studied. The study was based on the presence of relative hyperandrogenism in the pathogenesis of acne, due to the active synthesis of 5.alpha.-dihydrotestosterone sebocytes of sebaceous hair follicles of type III, and the fact that the predecessor of 5a-dihydrotestosterone is cholesterol. The study included 130 persons (60 women, 70 men) at the age of 17-36 years with acute stage of conglobate acne and disease duration from 3 months to 18 years. In addition 55 persons with papulopustule acne (23 women, 32 men) in similar age as control group were studied. A total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides were determined by semi-automatic biochemical analyzer BTS-350 using the kits of the company Deacon (Moscow). An abdominal organs and retroperitoneal space (liver, gall bladder, and pancreas) were examined by ultrasound diagnostic. Lipid metabolism changes were revealed in patients with conglobate acne, and was not found in patients with papulopustule acne. This lipid changes were associated with a tendency to increase in triglycerides, total cholesterol, lowering LDL cholesterol in HDL cholesterol content. It’s noted that in papulopustule form were not registered a higher LDL cholesterol levels but in conglobate form this parameter were 7.69% patient. With increasing duration of the disease the concentration of triglycerides, total cholesterol, LDL cholesterol is rising, while lowering levels of HDL cholesterol at the development of chronic pancreatitis.
Pyogenic granulema in dermatologist practice
Authors: Tarasenko Grigoriy N. , Tarasenko Y. G , Bekoeva A. V , Protiuc Oksana
Published: September 2020

Cases of pyogenic granulema on hand and face of child which have arisen after small traumas are presented. Patients complained about tumor formations easily bleeding at an insignificant trauma. In one case histologic examination confirmed the diagnosis. Electrocoagulation of the tumor was performed. No complications were detected. Disease recurrence was observed. Dermatologists should carry out differential diagnostics with tumor formations (nodular melanoma, sarcoma of Kaposhi and others).
Major-General of medical service, corresponding member of the Academy of Medical Science of the USSR, professor S.T. Pavlov (to the 120 anniversary)
Authors: Stochik A. A
Published: September 2020

The article describes the major biographic milestones and scientific contribution of the Russian dermatologist-venereologist, corresponding member of the Academy of Medical Science of the USSR S.T. Pavlov (1897-1971). S.T. Pavlov is the author of over 80 scientific works, devoted mainly to pathogenesis and clinics of eczema, atopic eczema, parapsoriasis, general pathology of syphilis, morbidity of dermatoses among military men and teaching methodology of dermatology and venetreology.
CLINICAL CASE OF MULTIPLE STEATOCYSTOMA
Authors: Molochkov V. A , Khlebnikova Albina N. , Molochkova Yu. V
Published: September 2020

A description of a rare disease multiple steatocystoma is presented. The disease is characterized by the development of cysts of hair follicle walls and sebaceous gland ducts. Clinical signs are multiple yellow-colored nodules located in the areas with high density of sebaceous glands. Description of clinical case of multiple steatocystoma at 31-year-old female patient, that was treated for a long time with an “unknown dermatosis” and literature review are presented. The correct diagnosis was verified based on anamnesis, clinical findings and pathomorphologic study.
СHROMOSOMAL REARRANGEMENTS AND ATOPIC DERMATITIS
Authors: Svechnikova Elena V.
Published: September 2020

Objective. To determine the frequency and patterns of chromosomal abnormalities in patients with atopic dermatitis. Material and methods. 470 patients with torpid variant of atopic dermatitis were observed. The study included patients with established and recorded in the medical record diagnosis of atopic dermatitis, which has been confirmed in accordance with the diagnostic criteria of J. Hanifin and G. Rajka. Karyological study was performed to 47 patients with skin rash, interpreted as atopic dermatitis and various polysystemic lesions that could be associated with chromosomal aberrations. Results. According to results of karyotyping, 8 (17%) patients had a variety of deviations from the normal karyotype, which made 1.8%. In 3 cases the karyotype corresponding to syndrome Turner was detected. One patient had karyotype 46XY inv7 (gh ph). In 2 patients minor, differing in size inversion of chromosome 9 was detected. In 2 patients translocation forms of chromosomal rearrangements were identified. Conclusion. Given that the prevalence of chromosomal diseases in the population is 0.5%, the frequency of chromosomal rearrangements obtained in this study was 1.8%, significantly higher than general population figures. According to the results, we can recommend karyotyping for torpid form of atopic dermatitis particularly with concomitant pathology polysystemic or reproductive harm.
CORRECTION OF VARIOUS TYPES OF FACIAL HYPERPIGMENTATION USING MICROPLASMA RADIO FREQUENCY TECHNOLOGY
Authors: Pinson I. Ya , Olisova Olga Yurievna , Verkhoglyad I. V
Published: September 2020

Correction of facial hyperpigmentation is a very common and complex problem faced by dermatologists, cosmetologists and plastic surgeons. Recently developed microplasma radiofrequency technology allows to accurately and rapidly affect the areas with hyperpigmentation and is an effective method of its treatment. The aim of this study is to evaluate the effectiveness of hyperpigmentation treatment using microplasma radiofrequency technology. The study included 35 patients with benign hyperpigmentation with localization on the face. All patients had II - IV skin phototypes according to Fitzpatrick. We used a device with an output power of 60-90 W and performed 2-6 passes (rolling with a roller nozzle) in different directions. Three to five procedures were performed with 8-week intervals. As a result of treatment, all patients had improvement, which is manifested in clarification of hyperpigmentation spots of varying severity. Complications were not observed. Improvement of skin condition with reduction of hyperpigmentation phenomena was assessed by patients and physicians who compared digital images taken before the treatment and 2 months after the last procedure. The results of the study showed that the patients had a positive effect on the treatment of hyperpigmentation using microplasma radio frequency technology. The average index of pain intensity was estimated from 0 to 10 using a visual analog scale, which was 6.7 ± 0.7. After a course of therapy in 32 of 35 patients hyperpigmentation decreased by more than 51%, and 3 patients managed to achieve a clinical cure. The average improvement in the treatment of hyperpigmentation was 4.28. Thus, microplasma radiofrequency technology is a highly effective and safe method of treating facial hyperpigmentation.
HYPERPIGMENTATION OF THE SKIN: MODERN VIEWS ON ETIOLOGY AND PATHOGENESIS (PART 1)
Authors: Kruglova L. S , Ikonnikova E. V
Published: September 2020

Brief literature review of the etiology and pathogenesis of hyperpigmentation on the basis of modern scientific publications is presented. The review focuses on actively studied mechanisms of melanin synthesis in norm and pathology, the physiology of pigment cells (melanocytes), their interaction with other structures of the epidermis and dermis and on the mechanisms of regulation of melanogenesis. The main factors influencing the appearance of hyperpigmentation are described.
COMBINED PHOTOTHERAPY METHOD FOR VITILIGO
Authors: Olisova O. Yu , Pinson I. Ya , Myzina K. A , Garanyan Lusine G.
Published: September 2020

The results of combined phototherapy using UVB 311 nm and excimer laser 308 nm in 30 vitiligo patients over 18 years old (main group) are presented. As a comparison group, 30 patients with vitiligo (control group) received only narrow-band UVB therapy at 311 nm. The distribution of the clinical forms of vitiligo in both groups was uniform. Phototherapy with UVB rays was performed according to the procedure of 4-times irradiation per week, excimer laser - 2 times a week. As a result of the treatment in the main group, a clinical cure (repigmentation of more than 96%) was observed in 18 (60%) patients, a significant improvement (repigmentation 51-95%) in 8 (26.7%), improvement in 4 (13.3%). For this purpose it took from 16 to 48 (on average 32) the procedures of an excimer laser (the maximum single dose varied from 0.5 to 2.4 J/cm2 (mean 1.45 J/cm2), the course dose from 2.2 Up to 32 J/cm2 (14.7 J/cm2 on average) and from 24 to 82 procedures of UVB therapy at 311 nm (an average of 52), with a maximum radiation dose ranging from 1.3 to 3.7 J/cm2 ( the mean value of 2.45 J/cm2); the course dose was from the exchange rate of 26.8 to 80.2 J/cm2 (an average of 53.5 J/cm2). In the control group, as a result of 311 nm UVB therapy, clinical recovery was achieved in 7 (23.3%) patients, a significant improvement in 15 (50%), improvement in 8 patients (26.7%). In total patients received from 44 to 94 (an average of 69) procedures for treatment. The maximum radiation dose varied from 2.6 to 5.8 J/cm2 (mean 4.2 J/cm2); the course dose was from 44.4 to 98.7 J/cm2 (an average of 71.6 J/cm2). Portability of phototherapy with UVB rays of 311 nm in combination with an excimer laser of 308 nm and in the form of monotherapy was good in patients of both groups. Side effects from the action of UV rays were reduced to the manifestation of photodermatitis (without blisters) in 5 (8.3%) patients and dry skin in 7 (11.7%) patients. When comparing the obtained results, it was found that the efficiency of the phototherapy was significantly higher with a combination of narrow-band UVB therapy of 311 nm and an excimer laser of 308 nm (60% of patients with clinical cure) than with only one narrow-band phototherapy (clinical cure in 23.3% patients). Using the Cutometer 580 MPA CK electronic device (Germany) with a Mexameter MX 18nozzle before and after treatment melanin levels were determined in the vitiligo foci. After application of combined phototherapy with UVB rays of 311 nm and excimer laser of 308 nm, an increase in the melanin level by 2-2.5 times was revealed, which was clinically expressed in the repigmentation of lesions and was an objective evidence of the effectiveness of combined phototherapy.