bluuebunny/crossref_metadata_2025 huggingface dataset:
m6A-mediated ZNF750 repression facilitates nasopharyngeal carcinoma progression
Authors: Zhang Panpan , He Qiuping , Lei Yuan , Li Yingqin , Wen Xin , Hong Mengzhi , Zhang Jian , Ren Xianyue , Wang Yaqin , Yang Xiaojing , He Qingmei , Ma Jun , Liu Na
Published: December 2018

Nasopharyngeal carcinoma (NPC) progression is regulated by genetic, epigenetic, and epitranscript modulation. As one of the epitranscript modifications, the role of N6-Methyladenosine (m6A) has not been elucidated in NPC. In the present study, we found that the poorly methylated gene ZNF750 (encoding zinc finger protein 750) was downregulated in NPC tumor tissues and cell lines. Ectopic expression of ZNF750 blocked NPC growth in vitro and in vivo. Further studies revealed that m6A modifications maintained the low expression level of ZNF750 in NPC. Chromatin immunoprecipitation sequencing identified that ZNF750 directly regulated FGF14 (encoding fibroblast growth factor 14), ablation of which reversed ZNF750’s tumor repressor effect. Moreover, the ZNF750-FGF14 signaling axis inhibited NPC growth by promoting cell apoptosis. These findings uncovered the critical role of m6A in NPC, and stressed the regulatory function of the ZNF750-FGF14 signaling axis in modulating NPC progression, which provides theoretical guidance for the clinical treatment of NPC.
Proteasomal degradation of BRAHMA promotes Boron tolerance in Arabidopsis
Authors: Sakamoto Takuya , Tsujimoto-Inui Yayoi , Sotta Naoyuki , Hirakawa Takeshi , Matsunaga Tomoko M. , Fukao Yoichiro , Matsunaga Sachihiro , Fujiwara Toru
Published: December 2018

High levels of boron (B) induce DNA double-strand breaks (DSBs) in eukaryotes, including plants. Here we show a molecular pathway of high B-induced DSBs by characterizing Arabidopsis thaliana hypersensitive to excess boron mutants. Molecular analysis of the mutants revealed that degradation of a SWItch/Sucrose Non-Fermentable subunit, BRAHMA (BRM), by a 26S proteasome (26SP) with specific subunits is a key process for ameliorating high-B-induced DSBs. We also found that high-B treatment induces histone hyperacetylation, which increases susceptibility to DSBs. BRM binds to acetylated histone residues and opens chromatin. Accordingly, we propose that the 26SP limits chromatin opening by BRM in conjunction with histone hyperacetylation to maintain chromatin stability and avoid DSB formation under high-B conditions. Interestingly, a positive correlation between the extent of histone acetylation and DSB formation is evident in human cultured cells, suggesting that the mechanism of DSB induction is also valid in animals.
Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization
Authors: Bedewitz Matthew A. , Jones A. Daniel , D’Auria John C. , Barry Cornelius S.
Published: December 2018

Tropinone is the first intermediate in the biosynthesis of the pharmacologically important tropane alkaloids that possesses the 8-azabicyclo[3.2.1]octane core bicyclic structure that defines this alkaloid class. Chemical synthesis of tropinone was achieved in 1901 but the mechanism of tropinone biosynthesis has remained elusive. In this study, we identify a root-expressed type III polyketide synthase from Atropa belladonna (AbPYKS) that catalyzes the formation of 4-(1-methyl-2-pyrrolidinyl)-3-oxobutanoic acid. This catalysis proceeds through a non-canonical mechanism that directly utilizes an unconjugated N-methyl-Δ1-pyrrolinium cation as the starter substrate for two rounds of malonyl-Coenzyme A mediated decarboxylative condensation. Subsequent formation of tropinone from 4-(1-methyl-2-pyrrolidinyl)-3-oxobutanoic acid is achieved through cytochrome P450-mediated catalysis by AbCYP82M3. Silencing of AbPYKS and AbCYP82M3 reduces tropane levels in A. belladonna. This study reveals the mechanism of tropinone biosynthesis, explains the in planta co-occurrence of pyrrolidines and tropanes, and demonstrates the feasibility of tropane engineering in a non-tropane producing plant.
Reversible and selective ion intercalation through the top surface of few-layer MoS2
Authors: Zhang Jinsong , Yang Ankun , Wu Xi , van de Groep Jorik , Tang Peizhe , Li Shaorui , Liu Bofei , Shi Feifei , Wan Jiayu , Li Qitong , Sun Yongming , Lu Zhiyi , Zheng Xueli , Zhou Guangmin , Wu Chun-Lan , Zhang Shou-Cheng , Brongersma Mark L. , Li Jia , Cui Yi
Published: December 2018

Electrochemical intercalation of ions into the van der Waals gap of two-dimensional (2D) layered materials is a promising low-temperature synthesis strategy to tune their physical and chemical properties. It is widely believed that ions prefer intercalation into the van der Waals gap through the edges of the 2D flake, which generally causes wrinkling and distortion. Here we demonstrate that the ions can also intercalate through the top surface of few-layer MoS2 and this type of intercalation is more reversible and stable compared to the intercalation through the edges. Density functional theory calculations show that this intercalation is enabled by the existence of natural defects in exfoliated MoS2 flakes. Furthermore, we reveal that sealed-edge MoS2 allows intercalation of small alkali metal ions (e.g., Li+ and Na+) and rejects large ions (e.g., K+). These findings imply potential applications in developing functional 2D-material-based devices with high tunability and ion selectivity.
Design Optimization of Tumor Vasculature-Bound Nanoparticles
Authors: Chamseddine Ibrahim M. , Frieboes Hermann B. , Kokkolaras Michael
Published: December 2018

Nanotherapy may constitute a promising approach to target tumors with anticancer drugs while minimizing systemic toxicity. Computational modeling can enable rapid evaluation of nanoparticle (NP) designs and numerical optimization. Here, an optimization study was performed using an existing tumor model to find NP size and ligand density that maximize tumoral NP accumulation while minimizing tumor size. Optimal NP avidity lies at lower bound of feasible values, suggesting reduced ligand density to prolong NP circulation. For the given set of tumor parameters, optimal NP diameters were 288 nm to maximize NP accumulation and 334 nm to minimize tumor diameter, leading to uniform NP distribution and adequate drug load. Results further show higher dependence of NP biodistribution on the NP design than on tumor morphological parameters. A parametric study with respect to drug potency was performed. The lower the potency of the drug, the bigger the difference is between the maximizer of NP accumulation and the minimizer of tumor size, indicating the existence of a specific drug potency that minimizes the differential between the two optimal solutions. This study shows the feasibility of applying optimization to NP designs to achieve efficacious cancer nanotherapy, and offers a first step towards a quantitative tool to support clinical decision making.
Development of a novel RANKL-based peptide, microglial healing peptide1-AcN (MHP1-AcN), for treatment of ischemic stroke
Authors: Shimamura Munehisa , Nakagami Hironori , Shimizu Hideo , Mukai Hideyuki , Watanabe Ryosuke , Okuzono Takeshi , Kawano Tomohiro , Ikeda Yuka , Hayashi Hiroki , Yoshida Shota , Ju Nan , Mochizuki Hideki , Morishita Ryuichi
Published: December 2018

Although the regulation of post-ischemic inflammation is an important strategy to treat ischemic stroke, all clinical trials have failed to show its efficacy. To solve the problem, we previously developed a novel partial peptide of RANKL, microglial healing peptide 1 (MHP1), which could reduce ischemic injury by inhibiting Toll-like receptor (TLR) induced inflammation. However, optimization of the peptide was necessary to increase the stability and efficacies for clinical use. According to information gathered through HPLC/MS in serum, we have newly designed a series of modified MHP1 peptides and have found that N-terminal acetylation and C-terminal amidation in MHP1 (MHP1-AcN), can strengthen its anti-inflammatory effects and increase its stability with anti-osteoclastogenic effects. Anti-TLR activity was reported to be reduced in MHP1 when incubated at 37 °C for 24 hrs, but MHP1-AcN could keep the activity under the same condition. The therapeutic effect of MHP1-AcN was observed in transient ischemic stroke model at lower dose than MHP1. Importantly, MHP1-AcN did not affect thrombolytic effects of tissue plasminogen activator (tPA) and inhibited tPA-induced hemorrhagic transformation. These findings indicated that MHP1-AcN was stable and effective anti-TLR signal peptide and could be a promising agent for treating stroke patients receiving tPA and endovascular therapy.
Macromolecular crowding tunes 3D collagen architecture and cell morphogenesis
Authors: Ranamukhaarachchi S. K. , Modi R. N. , Han A. , Velez D. O. , Kumar A. , Engler A. J. , Fraley S. I.
Published: December 2018

Macromolecular crowding of collagen I during polymerization produces short, degradation-resistant fibrils that induce collective morphogenesis of breast cancer cells.
Gradiently degraded electrospun polyester scaffolds with cytostatic for urothelial carcinoma therapy
Authors: Wang Jixue , Wang Guanyu , Shan Hongli , Wang Xiaoqing , Wang Chunxi , Zhuang Xiuli , Ding Jianxun , Chen Xuesi
Published: December 2018

Gradiently degraded cytostatic-loaded electrospun polyester scaffolds as potential self-removing ureteral stents prevent the recurrence of urothelial carcinoma.
A layered titanium(iv)-peroxo-pyridine dicarboxylic cluster: crystal structure and photoelectrochemical sensing of dopamine
Authors: Li Caixia , Tao Ran , Jin Zhanbin , Li Fengyan , Fang Wencheng , Xu Lin
Published: December 2018

A water-soluble titanium(iv)-oxo-cluster (K6[K3Ti3O4(O2)3(C7H3O4N)3(OH2)2]Cl·4H2O)1has been successfully synthesized and it shows a 2D layered structure through the connection of potassium ions. Its application in photoelectrooxidation activity for DA was also investigated primarily.
Pb(ii) binding to the brain specific mammalian metallothionein isoform MT3 and its isolated αMT3 and βMT3 domains
Authors: Pérez-Zúñiga Catalina , Leiva-Presa Àngels , Austin Rachel Narehood , Capdevila Mercè , Palacios Òscar
Published: December 2018

MT3 can bind Pb2+ to form a variety of metallated Pb-MT3 species.
WSe2 nanoparticles with enhanced hydrogen evolution reaction prepared by bipolar electrochemistry: application in competitive magneto-immunoassay
Authors: Mazánek Vlastimil , Mayorga-Martinez Carmen C. , Bouša Daniel , Sofer Zdeněk , Pumera Martin
Published: December 2018

We have exfoliated WSe2 particles by the bipolar electrochemistry (BE). Thus obtained nanoparticles were tested towards hydrogen evolution reaction and then used as the electrochemical label in the immunoassay.
The equilibrium structure of self-assembled protein nano-cages
Authors: Panahandeh Sanaz , Li Siyu , Zandi Roya
Published: December 2018

Global minimum energy structures of protein nano-cages are investigated as a function of the mechanical properties of coat proteins.
Enhanced SiV photoluminescence by oxidation-induced nano-structures on diamond particle surfaces
Authors: Mei Yingshuang , Chen Chengke , Fan Dong , Jiang Meiyan , Li Xiao , Hu Xiaojun
Published: December 2018

The nano-pyramid and irregular nano-porous structure on the diamond particle surfaces were constructed by oxidation to enhance their SiV PL.
Catalytic asymmetric synthesis of 3-aryl phthalides enabled by arylation–lactonization of 2-formylbenzoates
Authors: Carlos Andressa M. M. , Stieler Rafael , Lüdtke Diogo S.
Published: December 2018

The catalytic asymmetric synthesis of 3-aryl phthalides through an asymmetric arylation–lactonization is enabled by a B/Zn exchange reaction.
Sub-10 nm domains in high-performance polyetherimides
Authors: Guo Dong , Khan Assad U. , Liu Tianyu , Zhou Zhengping , Liu Guoliang
Published: December 2018

After condensation with polystyrene oligomers, ultra-low-molecular-weight polyetherimide-based triblock copolymers form disordered nanostructures with domain sizes less than 8 nm.
In silico studies of diarylpyridine derivatives as novel HIV-1 NNRTIs using docking-based 3D-QSAR, molecular dynamics, and pharmacophore modeling approaches
Authors: Wan Youlan , Tian Yafeng , Wang Wenjie , Gu Shuangxi , Ju Xiulian , Liu Genyan
Published: December 2018

Computational modeling approaches were successfully applied to a series of diarylpyridine derivatives as novel HIV-1 NNRTIs.
Schiff base complex conjugates of bovine serum albumin as artificial metalloenzymes for eco-friendly enantioselective sulfoxidation
Authors: Tang Jie , Yao Pengfei , Wang Lina , Bian Hedong , Luo Meiyi , Huang Fuping
Published: December 2018

Artificial metalloenzymes have been prepared by non-covalent insertion of transition metal Schiff-base complexes into bovine serum albumin as the host protein and were characterized by UV-visible spectroscopy, ESI-TOF mass spectrometry and molecular docking studies.
Enhanced hydrogen storage properties of 1.1MgH2–2LiNH2–0.1LiBH4 system with LaNi5-based alloy hydrides addition
Authors: Zhao Wang , Wu Yuanfang , Li Ping , Jiang Lijun , Qu Xuanhui
Published: December 2018

The weakening of N–H bond and the homogeneous distribution of LaNi5-based alloy hydrides in the Li–Mg–B–N–H composite enhance its hydrogen storage properties.
Simultaneous optimization of ultrasonic-assisted extraction of antioxidant and anticoagulation activities of compounds from Leonurus japonicus Houtt. by response surface methodology
Authors: Tan Ya-Jie , Zhou Gui-Sheng , Guo Sheng , Yan Hui , Zhang Jing , Zhu Zhen-Hua , Shi Xu-Qin , Yue Shi-Jun , Tang Yu-Ping , Huang Sheng-Liang , Peng Guo-Ping , Duan Jin-Ao
Published: December 2018

Leonurus japonicus Houtt. is a herbaceous annual of the Lamiaceae family with pantropical distribution; it is called motherwort in China.
Toughening of POSS–MPS composites with low dielectric constant prepared with structure controllable micro/mesoporous nanoparticles
Authors: Jiao Jian , Shao Yudi , Huang Fenchao , Wang Jia , Wu Zhenzhen
Published: December 2018

A promising method to improve the performance of CE composites via combining advantages of POSS and MPS.
Effect of iron ion diffusion on the corrosion behavior of carbon steels in soil environment
Authors: Bai Ziheng , Xiao Kui , Dong Pengfei , Dong Chaofang , Wei Dan , Li Xiaogang
Published: December 2018

The corrosion behavior of metal materials in soil environments has been intensively studied recently.
Ca3Lu(AlO)3(BO3)4 : Sm3+: a novel red-emitting phosphor with high colour purity for NUV-based warm white LEDs
Authors: Khan Wasim ullah , Mane Sunilkumar Baburao , Khan Salim ullah , Zhou Dongdong , Khan Dilfaraz , Yu Qiaoxi , Zhou Weijie , Zhou Lei , Shi Jianxin , Wu Mingmei
Published: December 2018

Ca3Lu(AlO)3(BO3)4 : Sm3+: a novel red-emitting phosphor with high colour purity up to 98.53% and excellent thermal stability (the red emission intensity of CLAB : 0.05Sm3+ at 425 K is 86.6% of that at 300 K) for NUV-based warm white LEDs.
Kinetic study of hydroxyl radical formation in a continuous hydroxyl generation system
Authors: Wang Xin , Zhang Long
Published: December 2018

A novel and simple apparatus for the continuous generation of hydroxyl radicals has been constructed for the first time.
Pd-catalyzed [3 + 2] cycloaddition of vinylcyclopropanes with 1-azadienes: synthesis of 4-cyclopentylbenzo[e][1,2,3]oxathiazine 2,2-dioxides
Authors: Lin Yan , Wang Qijun , Wu Yang , Wang Chang , Jia Hao , Zhang Cheng , Huang Jiaxing , Guo Hongchao
Published: December 2018

Pd-catalyzed [3 + 2] cycloaddition of vinylcyclopropanes with 1-azadienes gave highly functionalized cyclopentane derivatives in high yields.
Triterpenoids with α-glucosidase inhibitory activity and cytotoxic activity from the leaves ofAkebia trifoliata
Authors: Ouyang Jin-Kui , Dong Li-Mei , Xu Qiao-Lin , Wang Jing , Liu Shao-Bo , Qian Tao , Yuan Yun-Fei , Tan Jian-Wen
Published: December 2018

Ten pentacyclic triterpenoids including a new multiflorane triterpene acid, 2α,3β,23-trihydroxymultiflor-7-en-28-oic acid (1), and a new lupane triterpene monoglucoside named akebiaoside C (2), were obtained from the leaves ofAkebia trifoliata.
Efficient in situ N-heterocyclic carbene palladium(ii) generated from Pd(OAc)2 catalysts for carbonylative Suzuki coupling reactions of arylboronic acids with 2-bromopyridine under inert conditions leading to unsymmetrical arylpyridine ketones: synthesis, characterization and cytotoxic activities
Authors: Touj Nedra , Al-Ayed Abdullah S. , Sauthier Mathieu , Mansour Lamjed , Harrath Abdel Halim , Al-Tamimi Jamil , Özdemir Ismail , Yaşar Sedat , Hamdi Naceur
Published: December 2018

The in situ prepared four component system Pd(OAc)2, 1,3-dialkylbenzimidazolium halides 2a–i and 4a–i, K2CO3 under CO atmosphere catalyses carbonylative cross-coupling reaction of 2-bromopyridine with various boronic acids to yield unsymmetrical arylpyridine ketones.
Evaluation of exfoliation degree of montmorillonite in aqueous dispersions through turbidity measurement
Authors: Chen Tianxing , Yang Yiming , Zhao Yunliang , Rao Feng , Song Shaoxian
Published: December 2018

In this work, the exfoliation of montmorillonite (MMT) in aqueous suspensions was investigated through the measurement of turbidity.
Modeling gas transport in polymer-grafted nanoparticle membranes
Authors: Barnett J. Wesley , Kumar Sanat K.
Published: December 2018

We show that coarse-grained molecular dynamics simulations do not capture experimental trends for the gas diffusion in matrix-free polymer-grafted nanoparticle-based membranes.
Recent advancements in and perspectives on flexible hybrid perovskite solar cells
Authors: Heo Jin Hyuck , Lee David S. , Shin Dong Hee , Im Sang Hyuk
Published: December 2018

In this review, we discuss the current state-of-art, research gateways and future prospects of flexible (bendable) perovskite solar cells (PSCs) towards their eventual commercialization.
Carbogels: carbonized conducting polyaniline/poly(vinyl alcohol) aerogels derived from cryogels for electrochemical capacitors
Authors: Bober Patrycja , Pfleger Jiří , Pašti Igor A. , Gavrilov Nemanja , Filippov Sergey K. , Klepac Damir , Trchová Miroslava , Hlídková Helena , Stejskal Jaroslav
Published: December 2018

Polyaniline cryogels supported with poly(vinyl alcohol) represent soft conducting macroporous materials suitable for conversion to aerogels by freeze-drying and, subsequently, to nitrogen-containing carbogels by carbonization.
Abundant grain boundaries activate highly efficient lithium ion transportation in high rate Li4Ti5O12 compact microspheres
Authors: Ma Jiaming , Wei Yinping , Gan Lin , Wang Chao , Xia Heyi , Lv Wei , Li Jia , Li Baohua , Yang Quan-Hong , Kang Feiyu , He Yan-Bing
Published: December 2018

It is a huge challenge for high-tap-density electrodes to achieve high volumetric energy density but without compromising the ionic transportation.
Energy level engineering in transition-metal doped spinel-structured nanosheets for efficient overall water splitting
Authors: Lai Feili , Feng Jianrui , Ye Xiaobin , Zong Wei , He Guanjie , Miao Yue-E , Han Xuemei , Ling Xing Yi , Parkin Ivan P. , Pan Bicai , Sun Yongfu , Liu Tianxi
Published: December 2018

A series of hollow polyhedrons are constructed with transition-metal doped spinel-structured nanosheets wrapped nitrogen-doped carbon polyhedrons for enhanced water splitting.
Comparative evaluation of the biocompatible and physical–chemical properties of poly(lactide-co-glycolide) and polydopamine as coating materials for bacterial cellulose
Authors: C. Lai , Zhang S. J. , Sheng L. Y. , Xi T. F.
Published: December 2018

The aim of this study was to investigate the influence of poly(lactide-co-glycolide) (PLGA) and polydopamine (PDA) as coating materials on the tensile strength, surface performance,in vitrocell behavior and thein vivomaterial-tissue reaction of bacterial cellulose (BC) membranes.
Tailorable, 3D structured and micro-patternable ionogels for flexible and stretchable electrochemical devices
Authors: Zhong Yong , Nguyen Giao T. M. , Plesse Cédric , Vidal Frédéric , Jager Edwin W. H.
Published: December 2018

A new family of ionogels for electrochemical devices was developed from a mixture of multifunctional thiols, diacrylate and triethylamine in the presence of ionic liquid using Michael addition chemistry.
Novel 9,9-dimethylfluorene-bridged D–π–A-type fluorophores with a hybridized local and charge-transfer excited state for deep-blue electroluminescence with CIEy ∼ 0.05
Authors: Qiu Xu , Ying Shian , Wang Cong , Hanif Muddasir , Xu Yuwei , Li Ya , Zhao Ruiyang , Hu Dehua , Ma Dongge , Ma Yuguang
Published: December 2018

Deep-blue electroluminescence with a maximum EQE of 5.74% and CIEy ∼ 0.05 is achieved based on a newly designed D–π–A fluorophore with a HLCT excited state.
Developmental Shifts in Detection and Attention for Auditory, Visual, and Audiovisual Speech
Authors: Jerger Susan , Damian Markus F. , Karl Cassandra , Abdi Hervé
Published: December 2018

Purpose

Successful speech processing depends on our ability to detect and integrate multisensory cues, yet there is minimal research on multisensory speech detection and integration by children. To address this need, we studied the development of speech detection for auditory (A), visual (V), and audiovisual (AV) input.

Method

Participants were 115 typically developing children clustered into age groups between 4 and 14 years. Speech detection (quantified by response times [RTs]) was determined for 1 stimulus, /buh/, presented in A, V, and AV modes (articulating vs. static facial conditions). Performance was analyzed not only in terms of traditional mean RTs but also in terms of the faster versus slower RTs (defined by the 1st vs. 3rd quartiles of RT distributions). These time regions were conceptualized respectively as reflecting optimal detection with efficient focused attention versus less optimal detection with inefficient focused attention due to attentional lapses.

Results

Mean RTs indicated better detection (a) of multisensory AV speech than A speech only in 4- to 5-year-olds and (b) of A and AV inputs than V input in all age groups. The faster RTs revealed that AV input did not improve detection in any group. The slower RTs indicated that (a) the processing of silent V input was significantly faster for the articulating than static face and (b) AV speech or facial input significantly minimized attentional lapses in all groups except 6- to 7-year-olds (a peaked U-shaped curve). Apparently, the AV benefit observed for mean performance in 4- to 5-year-olds arose from effects of attention.

Conclusions

The faster RTs indicated that AV input did not enhance detection in any group, but the slower RTs indicated that AV speech and dynamic V speech (mouthing) significantly minimized attentional lapses and thus did influence performance. Overall, A and AV inputs were detected consistently faster than V input; this result endorsed stimulus-bound auditory processing by these children.
Hybrid approach for ECG signal enhancement using dictionary learning‐based sparse representation
Authors: Rakshit Manas , Das Susmita
Published: December 2018

Electrocardiogram (ECG) signal quality enhancement is a crucial task in the computer‐based automated processing system. In this study, a dictionary learning (DL)‐based sparse representation framework is presented for ECG signal enhancement through denoising. Unlike, traditional filtering techniques, the proposed method removes both low‐ and high‐frequency noises for complete enhancement of the signal quality. The frequency localised DL‐based sparse representation approach is applied to remove both baseline wander and power‐line interference. The time‐localised and signal characteristics based DL‐based sparse representation scheme is employed for extraction of clean ECG components from white Gaussian noise and muscle artefact added noisy ECG record. Both qualitative and quantitative performance analyses are carried out using the Massachusetts Institute of Technology ‐ Beth Israel Hospital (MIT‐BIH) database, QT database and synthetic ECG signals. The efficacy of the proposed method is compared with the existing ECG denoising approaches using standard performance metrics: signal‐to‐noise ratio, root‐mean‐square error and percentage RMS difference. It is observed through the detailed study and analysis that the proposed approach outperforms the existing ones and can be served to further enhance the overall quality of ECG in a computer‐based automated medical system.
Analysis of multiple criteria selection and application of APEKS method in haul truck mining transport process
Authors: Patyk Michał , Bodziony Przemysław
Published: December 2018

Vehicle transport is a dominant type of technological processes in rock mines, and its profitability is strictly dependent on overall cost of exploitation. Rational design of mining transportation system based on haul trucks should result from thorough analysis of technical and economic issues, including both cost of purchase and its further exploitation, having a crucial impact on the cost of minerals extraction. Moreover, haul trucks should be selected with type of payload. In this paper a development of universal family of evaluation criteria as well as application of evaluation method for haul truck and processing system selection process for a specific exploitation conditions in surface mining have been carried out. This methodology presented in the paper is based on the principles of multicriteria optimization using one of method, i.e. APEKS. The result of the research is a universal methodology, and it consequently may be applied in other surface mines with similar exploitation parameters.
Machine Learning in predicting the extent of gas and rock outburst
Authors: Bodlak Maciej , Kudełko Jan , Zibrow Andrzej
Published: December 2018

In order to develop a method for forecasting the costs generated by rock and gas outbursts for hard coal deposit "Nowa Ruda Pole Piast Wacław-Lech", the analyses presented in this paper focused on key factors influencing the discussed phenomenon. Part of this research consisted in developing a prediction model of the extentof rock and gas outbursts with regard to the most probable mass of rock [Mg] and volume of gas [m3] released in an outburst and to the length of collapsed and/or damaged workings [running meters, rm]. For this purpose, a machine learning method was used, i.e. a "random forests method" with the "XGBoost" machine learning algorithm. After performing the machine learning process with the cross-validation technique, with five iterations, the lowest possible values of the mean-square prediction error "RMSE" were achieved. The obtained model and the program written in the programming language "R" was verified on the basis of the "RMSE" values, prediction matching graphs, out of sample analysis, importance ranking of input parameters and the sensitivity of the model during the forecast for hypothetical conditions.
OpenStreetMap land cover data quality assessment on the example of Lower Silesia Voivodship, Poland
Authors: Łuczak Jakub
Published: December 2018

OpenStreetMap (OSM) is an open source, freely available spatial database, co-created by users from around the world in the idea of volunteered geographic information. The functioning of the project as an open community geographic information system is its great advantage, however, it is associated with many flaws, like heterogeneity of collected data. The presented work focuses on the assessment of completeness and quality of land cover data. The reference data used in analysis were objects stored in the Baza Danych Obiektów Topograficznych (BDOT10k), which is an element of the Polish National Geodetic and Cartographic Resource. The analysis was carried out for the area of the Lower Silesia Voivodship. Despite the achievement of quite unsatisfactory results of the analysis, OpenStreetMap project has information potential and is useful in selected spatial analyses.
The problem of credibility studies on deformations of engineering objects in the geologically unstable area of Szczecin
Authors: Zygmunt Marek , Cacoń Stefan , Piotrowski Andrzej , Stępień Grzegorz
Published: December 2018

The location of reference points in deformation studies of engineering objects is often associated with low reliability of the obtained measurement results. This concerns the lack of proper diagnosis of the geological structure of the area. The reliability of deformation measurements is also low when we obtain data that only characterize the effects and not the cause-and-effects. The authors reviewed the influence of geological conditions on the formation of deformations of some engineering objects. The reference points were located in the immediate vicinity of the facilities, without taking into account the geological structure of the areas where the facilities were located. The proposed test method is based on a three-segment control and measurement system. An example of such considerations is the engineering facilities on the Grodzka and Ostrów Grabowski Island in the Szczecin area. The basic issue is to locate geologically stable areas in the vicinity of monitored engineering objects on the basis of geological substrate assessment and to analyse archival materials concerning periodical measurements of class 1 and 2 levelling lines in the Szczecin area. Reference points are located, which constitute the first segment of the control and measurement system. Subsequent segments of the system are organized with reference to the points of the first segment. This method provides reliable data on deformations of engineering objects.
Cable Insulation Failure Probability Analysis in Nuclear Power Plant Distribution Cabinet Fire
Authors: Li Qiang , Zhang Jia-qing , Li Jin-mei , Ren Shi-jing
Published: December 2018

This paper takes the nuclear power plant power distribution cabinet fire as example and adopts FPRA methodology to analyse the failure probability of cable insulation at contiguous region among distribution cabinet. The influential factor that fire brigade dealt with the fire in the spot is considered in this research. The cumulative distribution function of fire brigade’s arriving and extinguishing time is conducted discretization, confirming the sample statistics of areas and establishing the numbers of cable insulation failure events of distribution cabinet fire. Combining failure predicted model of cable insulation and calculating the failure situation of cable insulation under each of fire background, obtaining the probability that cable insulation failure events among the distribution cabinet fires. The results show that the HRRmax of distribution cabinet fire in term of case scenario is 750 kW, the cable never happens the insulation failure; when the distribution cabinet fire is 1000 kW, the possibility of cable insulation failure is 12.6%.
Research on the Thermo-mechanical Effect of Large-size Cables and its Influence on Insulation Based on Finite Element Method
Authors: Li Shengchong , Wang Fujue , Ma Hongzhong , Xu Honghua , Wang Chunning
Published: December 2018

In order to study the thermo-mechanical effect of large-size cables, the thermal-structural coupling model is established to calculate the stress and deformation of the cables based on finite element method. According to the model, the distribution characteristics of temperature, stress and deformation are analysed in this paper. It turns out that, the maximum stress appears in metal sheath and the largest axial deformation in insulation layer. By means of curve fitting, a quick formula is proposed to calculate the stress on metal sheath and the axial deformation of conductor. Finally, its influence on insulation is studied by the simulation of electric field. The results show that, the electric field strength on the surface of insulation layer increases significantly under this circumstance, leading to the occurrence of partial discharge.
The Study of Lighting Quality of LED and HPS Luminaires Based on Various Road Surface Properties
Authors: Yoomak Suntiti , Ngaopitakkul Atthapol
Published: December 2018

This paper presents analysis of lighting quality in different road surface conditions using the DIALux software. Dry and wet road surfaces are used to study lighting quality by following classifications of the International Commission on Illumination (CIE). Lighting quality of high pressure sodium (HPS) and light emitting diode (LED) luminaires are compared, based on roadway with a traffic island. Results indicate that the HPS luminaire can provide better average illuminance and average luminance values than the LED luminaire, resulting in positive visual performance. However, the LED luminaire can achieve visual and comfort performance including energy saving due to its light distribution efficiency. For lighting quality on different road surface conditions, the lighter dry road surface materials, the higher lighting quality. Wet road surfaces cause very bright areas on road surface alternating with large dark areas. It results in the average luminance of the surface increased while overall uniformity decreased.
Fuzzy Predictive Control of Wind Turbine Systems Via Singular Perturbation Theory
Authors: Zhang Yan , Yang Zhong , Si Haifei
Published: December 2018

In this paper, the maximum power point tracking problem of variable-speed wind turbine systems is studied. The mechanical and electromagnetic dynamics of the wind turbine systems are both taken into account. Since the electromagnetic parts change much faster than the turbine part, the whole system is modeled in two time scales base on singular perturbation theory. And a T-S fuzzy model predictive control strategy is then developed. The controller is validated with a wind turbine simulator. The results have shown better performance in comparison with existing controllers.
Adaptive Interpolated PI Gain Scheduling for Voltage Regulator in Solar Charge Controller Applications
Authors: Samman Faizal Arya , Hamka Dea Fatriziah , Diatmika Made Dharma Budy , Sahali Ida Rachmaniah
Published: December 2018

Buck-boost converter is one of the dc-dc convert0.er that can both increase and decrease the value of output voltage. Due to its wide output range, this converter is very appropriate for using in solar-based electric generation systems. To control the stable expected output voltage, this converter is usually integrated with feedback control. One of the old and widely used control techniques is PID control. However, conventional PID controls still have deficiencies, because the parameters of PID parameters are static so that for wide ranges of input or load will provide different transient responses. This paper will present a new PI control with an adaptive interpolated PI gain scheduling technique. The proposed control algorithm has been embedded and implemented in real microcontroller hardware and its performance has been tested under load change conditions, and the input voltage changes within the range of 8-22 V. Testing results show that PI control with gain scheduling technique produces better transient response compared to the traditional fixed PI controller. The time domain transient response measurements, under load changes within the range of 20-1000 Ohm, present that the proposed control algorithm give settling time value below 1.0 second, rise-time below 0.436 second, maximum overshoot below 0.5%, and the steady-state error below 0.3 V.
An effective methodology to design scale model of non-metallic structural entity
Authors: Yuan Liming , Xie Zhijie , Dai Fei , Xu Yonggang , Zhang Yuan
Published: December 2018

In order to solve the problem on designing scale model of non-metallic structural entity, a method is first proposed according to the high-frequency approximation algorithm, in which reflection coefficients of designed scale model are optimized to be as identical as possible with those of theoretical scale model. An example is given to verify the effectiveness of the method, where a non-metallic cone is constructed and FEKO is employed to simulate the monostatic radar Cross Section (RCS) of the designed scale cone and the theoretical scale cone. Result reveals that the monostatic RCS of the designed scale cone agrees very well with that of the theoretical scale cone. The mean deviation of the monostatic RCS is just 1.31 dB in simulated elevation angles of 0°~90°. Thus, the method proposed in this paper is of important theoretical and practical significance in constructing scale model of high accuracy.
The spheroidizing tendency and spheroidization mechanism of 75Cr1 steel
Authors: Huo Jiping , Zhou Chong , Wang Hua
Published: December 2018

Spheroidization annealing process was carried out on 75Cr1 steel after cold rolling. Using TEM, SEM and image analysis software Image-Pro Plus 6.0, the effects of cold rolling and spheroidization processes on microstructure and mechanical properties were analyzed. The result shows that the cold rolling leads to fragmentation of the cementite and formation of the defects, which induces faster lamellae break-up and accelerates the annealing process. With the increase of isothermal temperature and holding time, the dimension of the spheroidized carbides increase as driven by Ostwald ripening mechanism, whereas the hardness of the steel decreases. The prior cold rolling before annealing process causes the yield strength improve slightly, however shows little effect on the cold formability. The optimum heat treatment process is, holding the samples at 705oC for 6 hours with cold deformation ratio (ε) of 0.6.
Seismic retrofit of historical masonry walls by means of natural basalt fiber strips system (BFRP). Pre-modern concepts and innovative materials
Authors: Tempesta Giacomo
Published: December 2018

The paper deals with the design approach for post-seismic interventions aimed at safeguarding historical buildings in seismic areas, consisting prevalently of masonry structures that, by type of technology, even if within exceptional cases respectful of “the rule of art”, do not guarantee the compliance with the resources necessary for the demand for resilient and structural capacity. In particular, the paper deals with the issue of applying technologies that use constructive ideas and concepts of the past or, as they are usually called pre-modern, reinterpreting them through the use of innovative and extremely performing materials.
Application of Python language in UOE molding simulation of pipeline steel
Authors: Yeda Lian , Bing Zhang , Renqiang Wu
Published: December 2018

The ABAQUS plug-in interface based on Python language realizes geometrical design and automatic modeling of gas pipeline UOE molding, which solves the cumbersome problem of manually building complexgeometric models. In this study, the algorithm for different sizes of pipelines corresponding to different molds was designed. At the same time, as the ABAQUS kernel scripting program was written, a GUI interface was developed. The interface was used to realize automatic modeling and analysis and control of the calculation work, which laid a solid foundation for practical engineering application analysis.
Design and trial-produce of a special nail-tooth thresher for pulses crops
Authors: Xia Xianfei , Chen Qiaomin , Xiao Hongru , Yang Guang
Published: December 2018

Pulses crops are widely distributed in China, but mechanization production-level of this crops is relatively low at present. So, a special nail-tooth thresher for pulses crops was carried out in this project to solve the problem of mechanical threshing. The roller diameter, speed, length, and nail-tooth structure, stripper concave screen, power device and cleaning system are determined by detailed theoretical calculation. Testing result of the trial-production prototype showed that the threshing roller with large diameter and low rotating speed, the nail-tooth threshing mechanism and the concave plate screen with large spacing are suitable for the broad bean thresher. The optimal combination is roller speed 400 /min, feed quantity 1.2 kg/s and concave tolerance 54 mm. Testing results showed that impurity content and breaking rate of the developed nail-tooth type broad bean thresher were respectively 1.09 %and 3.45%, It could improve the efficiency of the pulses crops threshing process significantly.
Effect of mechanical activation duration on combustion parameters of Al-Mg-based high-energy systems
Authors: Sokolov Sergey , Dubkova Yana , Vorozhtsov Alexander , Kuznetsov Valery , Promakhov Vladimir , Zhukov Ilya
Published: December 2018

The paper studies dispersion, oxidation degree, burning rate and combustion heat in high-energy mixtures obtained from of Al-Mg powder materials depending on the duration of mechanical activation in a planetary mill. According to dispersion analysis by laser diffraction method, 3 h mechanical activation gives Al-Mg particles with average particle size of 30 μm compared to 180 μm particles obtained after 2 h activation. Thermogravimetric analysis (TG) and differential scanning calorimetry (DSC) were used to record TG/DSC curves and measure burning rate and combustion heat for synthesized powders in comparison with engineered Al-Mg powder PAM−4 (Novosverdlovsk Metallurgical Company, Yekaterinburg, Russia). It has been found that the injection of 6 h mechanically activated Al-Mg powder into high-energy compositions leads to 24 and 45% increase of burning rate and combustion heat compared to the compositions without additive.
Numerical study of the acoustic efficiency of a group of Helmholtz resonators of various configurations
Authors: Pisarev Pavel , Anoshkin Aleksandr
Published: December 2018

In this work the physical and mathematical models of predicting the effective acoustic properties of sound absorbing structures (Helmholtz resonators) in joint operation were formulated. Numerical simulation has been performed on the modeling of an acoustic wave in a model channel with resonators of various configurations. Research was carried out to optimize the mutual arrangement of Helmholtz cells (resonators) in sound-absorbing structures of resonant type. According to the results of the research, the mutual influence of closely located prismatic resonators in the model channel of rectangular shape was revealed. The most effective combinations of prismatic resonators were determined. Schemes and recommendations for the placement of composite and base resonators in sound-absorbing structures were developed. Unique single-layer composite sound-absorbing structures, working at several resonant frequencies, were developed.
Hydrodynamics features in cavitation devices under tangent medium input
Authors: Vitenko Tetiana , Droździel Paweł , Horodyskyi Nazar
Published: December 2018

Theoretically analysed design features of the working section of a hydrodynamic cavitation device with swirling input. Using the numerical methods of SolidWorks software and the Flow simulation module, fluid flow modeling was performed to describe similar processes. The comparison of the results of visual and experimental studies has been carried out. Visual observations indicate that the life cycle of vapor-gas bubbles and cavities in the design under study can be divided into several periods, in particular the formation of vapor-gas bubbles, their growth, generation of cavities, their volume increase, transformation and destruction. The influence of input and output hydrodynamic and technological parameters of the flow and design features on the character of the cavitation area and the form of cavitation were studied. According to the results of theoretical and experimental research, rational mode of operation of the cavitation device is proposed.
Determination of the force required for the hydroforming of al 99,5
Authors: Ceclan Vasile , Grozav Sorin
Published: December 2018

In this paper the authors present the hydroforming of the tubular parts. It also presents the technology of the tubular parts' hydroforming. In this paper we determine the forces necessary for the hydroforming process. They are also presented the mechanical parameters of the material that are used in the deformation process. Also, the variation in wall thickness of the aluminium specimen is determined before the deformation process
Analysis of the properties of bone cement with respect to its manufacturing and typical service lifetime conditions
Authors: Karpinski Robert , Szabelski Jakub , Maksymiuk Jacek
Published: December 2018

This paper analyses the impact of exposure to Ringer’s solution, an isotonic solution relative to the body fluids, on the strength of bone cement. Research was conducted in order to determine moisture uptake and strength degradation. Prior to mechanical tests, the samples were seasoned in the solution simulating the human body conditions and subsequently measured to determine their increase in weight. Samples were then tested, using MTS Bionix testing system, for compressive strength according to ISO Standard. The data obtained from the measurements allowed to develop a statistical model for predicting cement absorption rate over a longer period of time. Compression strength of both seasoned and unseasoned samples was measured over time. The results were analysed statistically to show an effect of seasoning on cement strength. Cement samples show moderate moisture uptake over time, together with some decrease of compressive strength. Correlation between two above mentioned, measured factors was proven and linear model prepared. Using obtained models, one can estimate the cement strength and moisture uptake over time.
The importance of proper evidence and identification of metallurgical materials for effective management of the company
Authors: Schindlerová Vladimíra , Šajdlerová Ivana
Published: December 2018

An important characteristic for efficient management of production systems is the ability of a product, component or material to be tracked. That is, to be assigned with a unique symbol, number, or other code (identifier) that can be traced back both within the production process and to the customer (e. g. when complaining about a defective part). Traceability leads to a cost reduction in eliminating the risks associated with the difficult identification of the material or parts, their handling in pre-production, the manufacturing process, or the storage and sale of finished products to customers. In case of problems, it makes it easier to implement the necessary measures and reduces the time to remedy the situation either within the company or even outside. Individual companies within the Czech Republic usually solve the identification and traceability independently. The paper deals with the results of the analysis of the current state of record keeping and identification of metallurgical materials in selected companies, and presents a proposal for improvement of the current situation in a specific company, especially in the field of work with remaining material.
The strength of traditional and self-pierced riveted joints
Authors: Rudawska Anna , Miturska Izabela , Stančeková Dana , Mucha Jacek
Published: December 2018

The objective of this study is to compare the strength of riveted joints fabricated by traditional riveting (with pre-drilled holes) and self-piercing riveting (SPR) for different types of joints. Riveted joints were produced using steel and aluminum alloy rivets and two types of sheet material: 235JR steel sheet and EN AW 6060 aluminum alloy sheet with the following dimensions: length l = 100 ± 1 mm, width b = 50 ± 1 mm and thickness g = 2 mm. For all tested types of riveted joints (pre-drilled and SPR), 5 sets of joints were fabricated, each set containing 6 samples. The sets of joints differed with respect to the number of rivets (1, 2, 3, 4 and 6 rivets), joint type (single-, three- and four-riveted joints) and lap length. For all tested joints, the highest load capacity was obtained for self-pierced riveted joints, while the lowest - for pre-drilled joints with aluminum alloy rivets. In addition, it was found that the shear strength of self-pierced riveted joints is higher than that of aluminum and steel blind rivets.