bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Synthesis and Some Transformations of Halogenalkene Ethers of 3‐Cyclohexene‐1‐carbonic Acid.
Authors: Veliyev M. G. , Mamedova N. A. , Mustafayev S. A.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Umpolung of Tropone: Preparation of 2‐Aroyl‐ and 2‐Acyltropones.
Authors: Horikoshi Hiroshi , Miyano Hiroyuki , Takayasu Tohru , Nitta Makoto
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Amino‐Substituted 1,3‐Bis‐(tert‐butyl‐NNO‐azoxy)benzenes. Part 2. 2‐Amino and 2,4‐Diamino Derivatives.
Authors: Frumkin A. E. , Churakov A. M. , Strelenko Yu. A. , Tartakovsky V. A.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium‐Catalyzed Terminal Alkyne Coupling Reaction of β‐Bromo‐β‐phenylthio or β‐Methylthio‐α‐trifluoromethyl Enol Ethers: A Convenient Synthesis of 2‐Sulfonyl‐1‐buten‐3‐ynes.
Authors: Yoshimatsu Mitsuhiro , Kinoshita Sayaka , Sugimoto Tomomi
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reductive Opening of Aziridines with Polymethylhydrosiloxane.
Authors: Chandrasekhar S. , Ahmed Moinuddin
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemistry of Acyl(imidoyl)ketenes. Part 4. Synthesis, Crystal and Molecular Structure of 3‐Benzoyl‐4‐benzylamino‐5‐phenyl‐5H‐furan‐2‐one.
Authors: Aliev Z. G. , Krasnykh O. P. , Maslivets A. N. , Stepanov O. S. , Andreichikov Yu. S. , Atovmyan L. O.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Isolation, and Dimerization and Trimerization of Monosubstituted Thiophene 1,1‐Dioxides.
Authors: Nakayama Juzo , Nagasawa Hidehiro , Sugihara Yoshiaki , Ishii Akihiko
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reactions of 3‐Amino‐1‐phenyl‐ and 3‐Amino‐1‐(thien‐2‐yl)‐4,4,4‐trifluorobut‐2‐en‐1‐ones with 1,2‐Diaminopropane and 1,2‐Diamino‐3,3,3‐trifluoropropane
Authors: Sosnovskikh V. Ya. , Kutsenko V. A. , Aizikovich A. Ya. , Korotaev V. Yu.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Oxidation of Enolate Anion by Hypervalent Iodine Compounds: Synthesis of α‐Tempo Carbonyl Compound, a New Living Radical Polymerization Initiator.
Authors: Ahn Kwang‐Hyun , Kim Younghun
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of Cyclic Amines by the Titanocene(II)‐Promoted Cyclization of Thioacetals Having a Carbon—Carbon Double Bond.
Authors: Fujiwara Tooru , Kato Yoshiko , Takeda Takeshi
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave Assisted Friedlaender Condensation Catalyzed by Clay.
Authors: Sabitha Gowravaram , Satheesh Babu R. , Subba Reddy B. V. , Yadav J. S.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Some 3,6‐Disubstituted Pyridazines.
Authors: Shin Mi‐Seon , Kang Young‐Jin , Chung Hyun‐A , Park Jung‐Won , Kweon Deok‐Heon , Lee Woo Song , Yoon Yong‐Jin , Kim Sung‐Kyu
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Behavior of 5,6‐Dihydrothieno[2,3‐h]cinnolin‐3(2H)‐one and 5,6‐Dihydrothieno[3,2‐h]cinnolin‐3(2H)‐one Towards Hydrazine. Synthesis of Thienocinnolinones and of 4‐Aminothienocinnolinones.
Authors: Villa Stefania , Cignarella Giorgio , Curzu Michela M. , Pinna Gerard A. , Pini Elena , Toma Lucio
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Labeled 1‐Azafagomine.
Authors: Hansen Steen Uldall , Bols Mikael
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Novel Quinoxaline‐5‐carboxylic Acid Derivatives.
Authors: Kornberg Brian E. , Nikam Sham S. , Rafferty Michael F.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient One‐Pot Route to Symmetrically and Unsymmetrically Substituted 1,4,7‐Triazacyclononanes also Results in the Isolation of a Stable Macrocyclic Aminal.
Authors: Pulacchini Sonia , Watkinson Michael
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Domino‐Hydroformylation—Allylboration—Hydroformylation for the Synthesis of trans‐2‐Alkylpiperidin‐3‐ols.
Authors: Hoffmann Reinhard W. , Brueckner David , Gerusz Vincent J.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Alkenylsilanes via Palladium(0)‐Catalyzed Silylation of Alkenyl Iodides with Hydrosilane.
Authors: Murata Miki , Watanabe Shinji , Masuda Yuzuru
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Addition of Chiral Triquinphosphoranes on Activated Carbonyl Compounds.
Authors: Marchi Caroline , Buono Gerard
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microbial Transformation of Δ9(15)‐Africanene.
Authors: Venkateswarlu Y. , Ramesh P. , Reddy P. Srinivasa , Jamil Kaiser
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Sesquiterpenoids from Achillea clypeolata.
Authors: Todorova Milka N. , Tsankova Elena T.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diterpenes from Haplopappus chrysanthemifolius.
Authors: Faini Francesca , Labbe Cecilia , Torres Rene , Delle Monache Franco , Delle Monache Giuliano
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Triterpenes with a New 9‐epi‐Cucurbitan Skeleton from Senecio selloi.
Authors: Ruecker Gerhard , Manns Detlef , Schenkel Eloir P. , Hartmann Rudolf , Heinzmann Berta M.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: On Steroids. Part 405. Structures and Synthesis of 4a‐Homo‐7,19‐dinorsteroids, X‐Ray Crystallography and NMR Spectroscopy.
Authors: Kasal Alexander , Budesinsky Milos , Pelnar Jan , Bruck Michael A.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of New Seven‐Membered Ring Cyclic Dipeptides from Functionalized β‐Amino Acids.
Authors: El Mahdi Ouafaa , Lavergne Jean‐Pierre , Martinez Jean , Viallefont Philippe , Essassi E. M. , Riche C.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Anthocyanin Pigments of Tulips.
Authors: Torskangerpoll Kjell , Fossen Torgils , Andersen Oeyvind M.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Intramolecular Cyclization of ortho‐(Cyclohex‐2‐enyl)anilines. Modified Synthesis of Ellipticine.
Authors: Mustafin A. G. , Khalilov I. N. , Ismagilov R. R. , Baimetov Z. M. , Spirikhin L. V. , Abdrakhmanov I. B. , Tolstikov G. A.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Enantioselective Approach to Total Synthesis of the Securinega Alkaloids: Application to (‐)‐Norsecurinine (XII) and Phyllanthine (XIX).
Authors: Han Gyoonhee , LaPorte Matthew G. , Folmer James J. , Werner Kim M. , Weinreb Steven M.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Alkaloid from Fluggea virosa: 14,15‐Epoxynorsecurinine.
Authors: Dehmlow Eckehard Volker , Guntenhoener Matthias , Van Ree Teunis
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Dulxanthone E (I): A Pyranoxanthone from the Leaves of Garcinia dulcis
Authors: Kosela Soleh , Hu Li‐Hong , Yip See‐Chung , Rachmatia Tiah , Sukri Tony , Daulay Tida S. , Tan Geok‐Kheng , Vittal Jagadese J. , Sim Keng‐Yeow
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Antibacterial and Antifungal Flavanones from Eysenhardtia texana.
Authors: Waechter Gerald A. , Hoffmann Joseph J. , Furbacher Todd , Blake Mary E. , Timmermann Barbara N.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 3‐o‐Methylfunicone, a Fungitoxic Metabolite Produced by the Fungus Penicillium pinophilum.
Authors: De Stefano Salvatore , Nicoletti Rosario , Milone Alfredo , Zambardino Salvatore
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Use of Artificial Neural Networks in a QSAR Study of anti‐HIV Activity for a Large Group of HEPT Derivatives.
Authors: Jalali‐Heravi M. , Parastar F.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Carbon Nanotubes. From Macromolecules to Nanotechnology
Authors: Ajayan P. M. , Charlier J.‐C. , Rinzler A. G.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mixed‐Bonded Open‐Framework Aluminophosphates and Related Layered Materials
Authors: Chen Jie‐Sheng , Pang Wen‐Qin , Xu Ru‐Ren
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of All‐Silica and High‐Silica Molecular Sieves in Fluoride Media
Authors: Camblor M. A. , Villaescusa L. A. , Diaz‐Cabanas M. J.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Scandium, Yttrium, the Lanthanides and the Actinides
Authors: Cotton S. A.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tetrakis(2,4,6‐triisopropylphenyl)diplumbene, a Molecule with a Lead—Lead Double Bond. New Plumbylenes and a Plumbylene Dimer with a Short Lead—Lead Separation: Synthesis of the First Plumbanediyl‐dimer
Authors: Seppelt Konrad
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recent Developments in the Chemistry of Spacer‐Bridged Distannoxanes
Authors: Schulte Marcus , Mehring Michael , Paulus Ingo , Schurmann Markus , Jurkschat Klaus , Dakternieks Dainis , Duthie Andrew , Orita Akihiro , Otera Junzo
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Reactivities of Cubane‐Type Sulfido Clusters Containing Noble Metals
Authors: Hidai Masanobu , Kuwata Shigeki , Mizobe Yasushi
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: N‐Haloreagents. Preparation of Chlorosulfonamide Sodium Salts and Their Application to Organic Synthesis
Authors: Kkoval' I. V.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemistry of Lycopene— A Review
Authors: Etoh Hideo , Singh Inder Pal
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Marine Natural Products as Leads to Develop New Drugs and Insecticides
Authors: El Sayed Khalid A. , Dunbar D. Chuck , Bartyzel Piotr , Zjawiony Jordan K. , Day William , Hamann Mark T.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Novel Bi‐ and Tricyclic Heteroactivated β‐Lactams by Pressure‐ Promoted [4 + 2]/[3 + 2] Tandem Cycloadditions of Enol Ethers and Nitrostyrene
Authors: Kuster G. J. T. , Kalmoua F. , Scheeren J. W.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Forensic and Toxicology Applications (of Solid‐Phase Microextraction)
Authors: Almirall Jose R. , Furton Kenneth G.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of New Multidentate Silicon‐ and Tin‐Containing Lewis Acids and Their Potential for Anion Complexation
Authors: Kuhn Silke , Hummeltenberg Reinhard , Schurmann Markus , Jurkschat Klaus
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Group 14 Homologues of Hydrocarbons
Authors: Mittag Emil J. , Herndon William C.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Aryl(methyl)acrylates and Polymers Based on Them
Authors: Syromyatnikov V. G. , Paskal' L. P. , Savchenko I. A.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Syntheses of Isochromane Analogues of the Michellamines and Korupensamines.
Authors: de Koning Charles B. , Michael Joseph P. , van Otterlo Willem A. L.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Double Insertion of the Difluoromethylene Unit from Trifluoromethylcopper into the Carbon—Copper Bond of Perfluoroaryl‐ and Perfluorovinylcopper Reagents: Preparation, Mechanism and Applications of New Fluorinated Copper Reagents.
Authors: Yang Zhen‐Yu , Burton Donald J.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel DAST‐Induced Debenzylative Cycloetherization in D‐1,2‐O‐Isopropylidene‐3,4,5‐tri‐O‐benzyl‐myo‐inositol.
Authors: Chung Sung‐Kee , Kwon Yong‐Uk , Ahn Young‐Hoon , Jeong Tae‐Heum , Chang Young‐Tae
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Modular amino acids‐based chiral ligands for copper‐catalyzed enantioselective conjugation addition of diethylzinc to cyclic enones
Authors: Gou Shaohua , Judeh Zaher M. A.
Published: June 2010

New amino acid‐based modular chiral ligands were readily synthesized and used to catalyze the asymmetric conjugate addition of Et2Zn to various cyclic enones in the presence of a variety of copper sources. Moderately high ee of up to 72% were obtained using ligand (S)‐1e under mild conditions. Chirality 2011. © 2010 Wiley‐Liss, Inc.
Chiral octahedral bimetallic assemblies with Δ‐TRISPHAT as counter anion: Design, anion metathesis, and Cp*Ir as a probe for chiral recognition
Authors: Damas Aurélie , Moussa Jamal , Rager Marie Noelle , Amouri Hani
Published: June 2010

The chiral octahedral bimetallic assemblies [(bpy)2Ru(o‐LIr)][CF3SO3]2 (2), [(ppy)2Rh(o‐LIr)][NO3] (7) and [(ppy)2Ir(o‐LIr)][NO3] (8) featuring chelating organometallic linker [Cp*Ir(η4‐o‐benzoquinone)] (o‐LIr) have been prepared and fully characterized. Anion metathesis following a convenient procedure allowed the preparation of the related diastereomers [Δ‐(bpy)2Ru(o‐LIr)][Δ‐TRISPHAT]2 (2a) and [Λ‐(bpy)2Ru(o‐LIr)][Δ‐TRISPHAT]2 (2b) as well as the octahedral rhodium [(Δ, Λ)‐(ppy)2Rh(o‐LIr)][Δ‐TRISPHAT] (7a, 7b) and iridium [(Δ, Λ)‐(ppy)2Ir(o‐LIr)][Δ‐TRISPHAT] (8a, 8b) bimetallic assemblies. 1H NMR studies in solution carried out on these compounds showed different behavior. For instance, the rhodium and iridium compounds exhibited weak chiral recognition in contrast the ruthenium compounds allowed facile differentiation between the two diastereomers suggesting that chiral recognition occurs between the enantiopure anion and the cationic part of the molecule. Chirality, 2010. © 2010 Wiley‐Liss, Inc.
Correlation of molecular human leukocyte antigen typing and outcome in high‐risk melanoma patients receiving adjuvant interferon
Authors: Gogas Helen , Kirkwood John M. , Falk Christine S. , Dafni Urania , Sondak Vernon K. , Tsoutsos Dimosthenis , Stratigos Alexandros , Markopoulos Christos , Pectasides Dimitrios , Spyropoulou‐Vlachou Maria
Published: June 2010

BACKGROUND:

Interferon is approved for adjuvant treatment of patients with stage IIB/III melanoma. The identification of predictive markers that would permit selection of patients would be beneficial. Specific human leukocyte antigen (HLA) class I and II antigens have previously shown an association with response to therapy or overall survival of patients with metastatic melanoma.

METHODS:

A total of 284 high‐risk melanoma patients participating in a randomized trial and 246 healthy controls were molecularly typed for HLA class I and II. Specific allele frequencies were compared between the healthy and patient populations, as well as presence or absence of these in relation to recurrence. Alleles related to autoimmune disease were also investigated.

RESULTS:

No significant differences were found between the distribution of HLA genotype in the melanoma population compared with healthy controls. Correlations between nonrecurrence and the presence of HLA‐Cw*06 allele were noted present in 19.3% of melanoma patients. The median relapse‐free survival of the Cw*06‐positive cohort was 100.2 months versus 37.3 months in the Cw*06‐negative cohort (P = .013). The median overall survival for the Cw*06‐positive cohort has not yet been reached, versus 78.9 months in the Cw*06‐negative cohort (P = .025). HLA‐Cw*06 was present in 29.79% of patients in the autoimmunity group and 15.38% of patients in the nonautoimmunity group (P = .049).

CONCLUSIONS:

No allele was associated with absence of recurrence in patients receiving adjuvant interferon with the exception of HLA‐Cw*06, an allele correlated with psoriasis. HLA‐Cw*06‐positive patients have better relapse‐free and overall survival. Cancer 2010. © 2010 American Cancer Society.
Telomere length and genetic analyses in population‐based studies of endometrial cancer risk
Authors: Prescott Jennifer , McGrath Monica , Lee I‐Min , Buring Julie E. , De Vivo Immaculata
Published: June 2010

BACKGROUND:

Telomeres are protective structures at the ends of linear chromosomes, regulated by a host of associated proteins. When telomeres become dysfunctional, genomic instability ensues. The vast majority of cells undergo apoptosis, although a rare cell may survive and become tumorigenic.

METHODS:

The authors used conditional logistic regression to examine relative telomere length in peripheral blood leukocytes, genetic variants at telomere maintenance gene loci (TERT, TNKS2, POT1, TERF1, TERF2), and endometrial cancer risk in case‐control studies nested within the Nurses' Health Study and the Women's Health Study.

RESULTS:

Relative telomere length was significantly inversely correlated with body mass index and weight gain since age 18 years. The authors did not observe a relationship between relative telomere length and endometrial cancer risk. Women in the shortest quartile had a multivariate‐adjusted odds ratio (OR) of 1.20 (95% confidence interval [95% CI], 0.73‐1.96; P for trend = .37) compared with women in the longest quartile. The authors found an elevation in endometrial cancer risk among women carrying at least 1 minor allele of RS2736122 (TERT; OR, 1.18; 95% CI, 1.01‐1.38) or RS12412538 (TNKS2; OR, 1.16; 95% CI, 1.00‐1.34).

CONCLUSIONS:

Relative telomere length was not associated with endometrial cancer risk. Other aspects of telomere maintenance remain to be explored. Cancer 2010. © 2010 American Cancer Society.
Promoting angiogenesis within the tumor microenvironment: The secret life of murine lymphoid IL‐17‐producing γδ T cells
Authors: Silva‐Santos Bruno
Published: June 2010

After two decades in the shadow of their αβ counterparts, γδ T cells have recently gathered significant attention following the discovery that they produce IL‐17 in various mouse models of infection and autoimmune disease. In contrast, the secretion of large amounts of IFN‐γ by γδ T cells has long been known, and has been tightly linked to their anti‐tumor function. In this issue of the European Journal of Immunology, a study unexpectedly reports that the lymphoid γδ T cells that infiltrate tumor foci induced in the mouse skin produce very little IFN‐γ, but abundant IL‐17. In fact, these γδ T cells are the major source of IL‐17 within the tumor microenvironment, where they appear to promote angiogenesis, and thus tumor growth. This Commentary discusses the relevance of these interesting findings in the context of the currently paradoxical pro‐ versus anti‐tumor roles of IL‐17 in cancer immunology.
A Urea‐Linked Glucosamine Dimer as a Building Block for the Synthesis of Linear and Cyclic Neosaccharides
Authors: Cirillo Luigi , Silipo Alba , Bedini Emiliano , Parrilli Michelangelo
Published: June 2010

A novel urea‐linked glucosamine dimer was obtained through a modification of the standard oxazolidinone closure reaction on a 2,3‐amino alcohol monomer and fully characterized by NMR spectroscopy and by molecular mechanics and dynamics techniques. A mechanism was proposed for the dimerization reaction that was based on the formation of a 2,3‐bis[(p‐nitrophenoxy)carbonyl] intermediate. Chemoselective manipulations on the orthogonal protecting group pattern of the dimer – especially on its unprecedented oxazolidinone–urea–oxazolidinone system – gave an alcohol building block that was useful for access to higher linear and cyclic neosaccharides. The conformational features and 3D‐characterization of a novel carbamate‐linked neodisaccharide macrocycle was accomplished through molecular mechanics and dynamics calculations.
Does rejection lead to disidentification? The role of internal motivation and avoidance strategies
Authors: Matschke Christina , Sassenberg Kai
Published: June 2010

Getting rejected can either push newcomers out of the group or make them try harder to become accepted. It is suggested that newcomers' internal motivation to become a group member and their strategies determine the outcomes of rejection. It was expected that in rejected newcomers, avoidance strategies (but not approach strategies) lead to stronger disidentification. Moreover, the disidentification effect of avoidance strategies is predicted to be buffered by the internal motivation to become a group member. Two studies supported these predictions. Study 1 manipulated the group's feedback (rejection vs. acceptance) and assessed internal motivation and strategies. Study 2 measured feedback and replicated the findings in the field. Thus, by the adoption of the right motivational approach, newcomers can prepare themselves not to be driven out of a new group by the almost unavoidable experiences of rejection. Copyright © 2010 John Wiley & Sons, Ltd.
How old is Luzia? Luminescence dating and stratigraphic integrity at Lapa Vermelha, Lagoa Santa, Brazil
Authors: Feathers James , Kipnis Renato , Piló Luis , Arroyo‐Kalin Manuel , Coblentz David
Published: June 2010

During an excavation in the 1970s, a disarticulated female human skeleton, later nicknamed Luzia, was discovered at 12m depth at Lapa Vermelha rockshelter in central Brazil. Radiocarbon dating of associated charcoal suggested an age of 11.4‐16.4 ka for the skeleton. The scattering of the skeletal parts, some uncertainty about the exact provenience of the skeleton, and evidence of pervasive insect turbation in the archaeological layers have raised doubts about the accuracy of the age. Luminescence dates for the depositional ages of the sediments at Lapa Vermelha are reported here. Single‐grain optically stimulated luminescence (OSL) of quartz along with grain‐size, chemical and micro‐morphological analyses of the sediments were employed to assess stratigraphic integrity, particularly the degree of sediment mixing. These various lines of evidence point to high stratigraphic integrity with little mixing at Lapa Vermelha. Sediments closest to where Luzia was recovered give OSL ages ranging from 12.7 to 16.0 ka, thus not refuting the original dates. © 2010 Wiley Periodicals, Inc.
Occupation surfaces sealed by the Avellino eruption of Vesuvius at the Early Bronze Age village of Afragola in southern Italy: A micromorphological analysis
Authors: Matarazzo Tiziana , Berna Francesco , Goldberg Paul
Published: June 2010

This paper reconstructs the use of space and defines activity areas within a single hut (Hut 8) at the Early Bronze Age village of Afragola (southern Italy). The village, consisting of a number of huts and other structures, was covered by approximately 1m of volcanic ash during the eruption of Vesuvius in 3550 ± 20BP. Thirteen samples were collected from inside the hut to analyze the spatial variability in sedimentary characteristics among three areas of Hut 8—the apsidal, central, and entrance areas. The micromorphological analysis revealed details about the occupation surface and its relationship to features and material remains in the hut not apparent in the field. The apsidal area was probably used for storage but not of solids, as no significant quantities of organic material were found. The central area contains a small oven, calcareous ash from fires, and organic material composed of charred remains and bone fragments and was likely used for small‐scale household tasks. A possible connection exists between the lithics and the microstratigraphic sequencing in the area west of the oven, suggesting that people congregated there to perform specific tasks. The entrance area contains highly compacted and heterogeneous sediments that were brought in from outside. Notable is the paucity of anthropogenic materials found inside the hut, especially given the remarkable preservation offered by the thick cover of volcanic ash. We hypothesize that Hut 8 was not occupied long enough to produce a large amount of debris or that it had limited indoor activities and was thoroughly cleaned. © 2010 Wiley Periodicals, Inc.
Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma
Authors: Hirata Hiroshi , Hinoda Yuji , Nakajima Koichi , Kawamoto Ken , Kikuno Nobuyuki , Ueno Koji , Yamamura Soichiro , Zaman Mohd S. , Khatri Gaurav , Chen Yi , Saini Sharanjot , Majid Shahana , Deng Guoren , Ishii Nobuhisa , Dahiya Rajvir
Published: June 2010

The functional significance of Wnt antagonist DKK1 has not been investigated in renal cell carcinoma (RCC). Therefore, we hypothesized that DKK1 may be a tumor suppressor gene and is epigenetically silenced, thus decreased DKK1 may cause progression of RCC. To assess the function of DKK1, we established stable DKK1 transfected cells and monitored them regarding cell viability, colony formation, apoptosis, cell cycle, and invasive capability. RCC cell lines had decreased levels of DKK1, which were increased after treatment with 5‐Aza‐2′‐deoxycytidine and trichostatin A. In chromatin immunoprecipitation assay, the level of dimethyl H3K9 and trimethyl H3K27 was decreased after 5‐Aza‐2′‐deoxycytidine/trichostatin A treatment in RCC cell lines. Increased methylation was also associated with higher pathological stages in primary RCC tissues. T‐cell factor/lymphoid enhancer factor activity and nuclear beta‐catenin expression were not changed in DKK1 transfectants. Also the expression of cyclinD1 and c‐Myc was not changed in DKK1 transfectants. These results suggest that DKK1 may not be involved in the beta‐catenin dependent pathway. We also evaluated the expression of various related genes. Cleaved caspase3, p53, p21 and puma expression were significantly upregulated in the DKK1 transfected cells. The population of apoptotic cells was increased in stable DKK1 cells and tumor growth suppression was also observed in nude mice with DKK1 transfected cells. In conclusion, this is the first report to show that DKK1 expression is epigenetically silenced in kidney cancer and its reexpression induces apoptosis and cell cycle arrest in RCC.
Honoring children, mending the circle: cultural adaptation of trauma‐focused cognitive‐behavioral therapy for American Indian and Alaska Native children
Authors: BigFoot Dolores Subia , Schmidt Susan R.
Published: June 2010

American Indians and Alaska Natives are vulnerable populations with significant levels of trauma exposure. The Indian Country Child Trauma Center developed an American Indian and Alaska Native (AI/AN) adaptation of the evidence‐based child trauma treatment, trauma‐focused cognitive‐behavioral therapy. Honoring Children, Mending the Circle (HC‐MC) guides the therapeutic process through a blending of AI/AN traditional teachings with cognitive‐behavioral methods. The authors introduced the HC‐MC treatment and illustrated its therapeutic tools by way of a case illustration. © 2010 Wiley Periodicals, Inc. J Clin Psychol: In Session 66:1–10, 2010.
Lead identification and optimization in crude samples using label free resonant acoustic profiling
Authors: Schnerr Helge R
Published: June 2010

Detecting the molecular basis of protein–protein recognition is an essential element in understanding protein function because their ability to form specific complexes with other proteins underlies most cellular processes. The use of labels has limitations, such as changes to the binding kinetics due to the alterations in structure and function that occur with label addition, difficulty in detecting biochemical activities and the need for additional steps in assay development. These issues have driven the development of label‐free formats for identifying the full range of biochemical activities.

Although optical‐based systems dominate the label‐free biosensor market, electrochemical, piezoelectric and acoustic devices represent similar but significantly less expensive alternatives. Acoustic biosensors have been employed in the label‐free detection of an incredibly broad range of analytes, from interfacial chemistries and lipid membranes, to small molecules and whole cells.

Resonant acoustic profiling (RAP) technology offers label‐free, real‐time analysis of biomolecular interactions and offers an efficient way to optimize the development and production process of recombinant proteins. RAP measures only the physical binding events and is insensitive to refractive index and colour changes. This enables direct measurement in undiluted crude and complex samples, such as cell culture media or periplasmic extracts, without intensive assay calibration. This advantage simplifies experimental design and eliminates expensive time‐consuming purification of often limited material, while delivering high content information. In this respect RAP technology reduces costs and increases the throughput and the density of information to optimize and control the processes more effectively. Copyright © 2010 John Wiley & Sons, Ltd.
The Effect of timing of conversion from external fixation to secondary intramedullary nailing in experimental tibial fractures
Authors: Sigurdsen Ulf , Reikeras Olav , Utvag Stein Erik
Published: June 2010

Diaphyseal tibial fractures with initial temporary external fixation (EF) are usually converted to intramedullary nailing (IMN) within 2 weeks, and no consensus on the optimal conversion time point exists. Current clinical practice is mainly based on estimation of the risk of postoperative infection. This is the first investigation of the effect of timing of such conversion on fracture healing. Forty male rats received a standardized tibial shaft osteotomy and EF. The animals were then randomly assigned to conversion to IMN at either 7 (group A, N = 10), 14 (group B, N = 10), or 30 (group C, N = 10) days after initial fixation. Group D (N = 10) served as a control group without conversion. Evaluation at 60 days included X‐ray, DXA, and mechanical testing. Group A had significantly increased bone mineral content and callus area compared to the control group. Groups B and C showed significantly inferior mechanical bending strength and rigidity compared to both group A and the control group (D). The timing of the conversion procedure has a significant effect on fracture healing. Early conversion procedure did not improve healing compared to control, but was advantageous compared to late conversion (at 2 or 4 weeks) with higher mineralization and superior biomechanical properties. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29:126–130, 2011
Separation and purification of hydrolyzable tannin from Geranium wilfordii Maxim by reversed‐phase and normal‐phase high‐speed counter‐current chromatography
Authors: Liu Dan , Su Zhiguo , Wang Changhai , Gu Ming , Xing Siliang
Published: June 2010

Three hydrolyzable tannins, geraniin, corilagin and gallic acid, main active components of Geranium wilfordii Maxim, have been separated and purified in one‐step by both reversed‐phase and normal‐phase high‐speed counter‐current chromatography. Gallic acid, corilagin and geraniin were purified from 70% aqueous acetone extract of G. wilfordii Maxim with solvent system n‐hexane–ethyl acetate–methanol–acetic acid–water (1:10:0.2:0.2:20) by reversed‐phase high‐speed counter‐current chromatography at purities of 94.2, 91.0 and 91.3%, at yields of 89.3, 82.9 and 91.7%, respectively. Gallic acid, corilagin and geraniin were purified with solvent system n‐hexane–ethyl acetate–methanol–acetic acid–water (0.2:10:2:1:5) by normal‐phase high‐speed counter‐current chromatography at purities of 85.9, 92.2 and 87.6%, at yields of 87.4, 94.6 and 94.3%, respectively. It was successful for both reversed‐phase and normal‐phase high‐speed counter‐current chromatography to separate high‐polarity of low‐molecular‐weight substances.
Solvent‐enhanced headspace sorptive extraction in the analysis of the volatile fraction of matrices of vegetable origin
Authors: Sgorbini Barbara , Budziak Dilma , Cordero Chiara , Liberto Erica , Rubiolo Patrizia , Sandra Pat , Bicchi Carlo
Published: June 2010

The solvent‐enhanced headspace sorptive extraction technique aims at modifying PDMS polarity using a solvent to increase its concentration capability. In solvent‐enhanced headspace sorptive extraction, a PDMS tubing closed at both ends by small glass stoppers and filled with an organic solvent is suspended in the sample headspace for a fixed time. After sampling, the sampled analytes are recovered from the PDMS tubing by thermal desorption and online transferred to a GC–flame ionization detector or GC‐MS system for analysis. Cyclohexane, iso‐octane, ethyl acetate, acetone, acetonitrile and methanol were tested as PDMS modifiers to sample the volatile fractions of sage (Salvia lavandulifolia Vahl.), thyme (Thymus vulgaris L.) and roasted coffee. Ethyl acetate was found to be the most effective PDMS modifier for all matrices investigated; although to a lesser extent, cyclohexane also increased component recoveries with sage and thyme. Acetone, acetonitrile and methanol did not increase PDMS recovery, while isooctane was excluded because of its interaction with the polymer. The results show that solvent‐modified PDMS extends the range of sampled headspace components with different polarities, increases the recovery of many of them, improves sensitivity in trace analysis, speeds up recovery and gives repeatability comparable with that of unmodified PDMS.