bluuebunny/crossref_metadata_2025 huggingface dataset:
Paradigm Shift of Statistical Big Data in Healthcare: Management, Analysis and Future Prospects
Authors: Dila Ram Bhandari  , Ron Kenett
Published: August 2023

‘Big data’ is vast describing volumes of information that can work miracles. Multiple attempts designed at highlighting the relationship between big data analytics and benefits for healthcare organizations have been raised. The big data influence on health organization management is still not clear due to the relationship’s multi-disciplinary nature.  It has become a topic of special interest for the past two decades because of a great potential that is hidden in it. Numerous public and private sector industries generate, store, and analyze big data with an aim to improve the services they provide. In the healthcare industry, various sources for big data include hospital records, medical records of patients, results of medical checkups, and devices that are a part of internet of things. Biomedical research also produces a significant share of big data pertinent to public healthcare. Big Data and healthcare are precarious to discourse the risk of hospitalization. This data requires proper management and analysis in order to derive expressive communication. There are various encounters associated with each step of handling big data which can only be surpassed by using high-end computing solutions for big data analysis. Providing relevant results for improving public health, healthcare providers are required to be fully equipped with appropriate infrastructure to systematically generate and analyze big data. A well-organized management, analysis, and interpretation of big data can transformation the game by opening new avenues for contemporary healthcare. With a strong integration of biomedical and healthcare data, modern healthcare institutes can probably revolutionize the medical therapies and personalized medicine.
Student and Clinical Educator Perceptions of the Impacts of COVID-19 on Final Year Veterinary Clinical Training in a Distributed Learning Model
Authors: Yi Joanne , Adams Cindy , Chalhoub Serge , Checkley Sylvia , McMillan Chantal
Published: August 2023

Delivery of the 4th year clinical program at the University of Calgary Veterinary Medicine (UCVM) is facilitated through the Distributed Veterinary Learning Community (DVLC) which has underwent major revisions in response to the COVID-19 pandemic. To determine the perceptions of how COVID-19 impacted 4th-year clinical rotations, students ( n = 24) and DVLC practice rotation coordinators (PRCs, n = 23) completed two questionnaires over a 7-month period. The survey consisted of demographic questions, statements ranked on an agreement scale, and open-ended questions. Two-tailed Wilcoxon signed-rank tests and frequency counts were used to analyze their responses over time. Quantitative analysis revealed that 45% students reported concerns for the mental health, 41% for their physical health, 26% for inadequate clinical time, and 14% cover communication that heightened over a 7-month period. No trends in responses were noted with PRCs overtime. Qualitative thematic analysis of students’ responses showed perceived advantages of lower client-induced performance pressure (22%) and longer rotations allowing for increased case responsibility (22%). PRCs felt fulfillment while teaching (50%), enjoyed longer rotations (50%), and used this opportunity to offer future employment opportunities to students (44%). Additionally, there were concerns regarding inadequate clinical time (41%), decreased ability to practice in-person client communication skills (26%), and difficulties enforcing social distancing protocols (43%). Areas of improvement identified from this study include providing clear communication, continued academic support, and normalizing mental healthcare. Continued adaptations to an ever-changing pandemic landscape can help mitigate the negative effects for future outbreaks and novel situations.
Fiziğin Optik Alt Alanı: Belirleyici Bir Terminoloji Çalışması
Authors: KURT Havva Sibel , YILDIRIM YAŞAR Ceylan
Published: August 2023

Fizik terminolojileri, öğrencilerin etkileşim içinde oldukları tüm ders kitapları, ders materyalleri ve sınıf içi deneyimleri açısından ve ayrıca bu alanda çalışan Fizik Eğitimcileri ile fizikçiler, fizik alanıyla ilgilenenler, optisyenler, dil hizmeti sağlayıcıları ve daha özelde çevirmenler için elzemdir. Bu çalışma, fiziğin optik alt alanı özelinde Fransızca-İngilizce-Türkçe üç dilli belirleyici bir terminolojinin oluşturulmasına odaklanmaktadır. Çalışmanın önemi, fiziğin optik alt alanında Fransızca-İngilizce-Türkçe dillerinde belirleyici bir terminolojinin oluşturulmasıyla, gerek Fransızcadan Türkçeye optik alanı özelinde terminoloji eksikliğinin giderilmesine katkı sağlamasından gerekse Fransızca-İngilizce-Türkçe üç dilli optik terminolojisi ihtiyacına yanıt vermesinden gelmektedir. Araştırma, “belirleyici terminoloji çalışması” ilkelerine göre yürütülmüştür. Bu çerçevede, fiziğin optik alt alanında ilgili dillerde standartlaşmayı sağlamak için, güncel ve güvenilir kaynaklara başvurularak belirli belirtimlerin kullanılması önerilmektedir. Bu çalışmada sunulan Fransızca-İngilizce-Türkçe optik terminolojisi, fiziğin optik alanındaki tüm terimleri kapsadığı iddiasında olmamakla birlikte, optik alanında Fransızca-İngilizce-Türkçe dillerinde standart, önerilen veya tercih edilen kullanımları sunarak, alan dilinde tutarlılığın sağlanmasına ve optik terminolojisine ihtiyaç duyanların güncel ve standart bir terminoloji kullanmasına imkân tanıyabilir.
“It's a pity that you were not with us...”
Authors: Malakhov Viktor , Chaika Tetiana
Published: August 2023

Reflections about authors’ participation in Alushta Schools of Young Philosophers.
Utilization of three-dimensional fusion images with high-resolution computed tomography angiography for preoperative evaluation of microvascular decompression: patient series
Authors: Iwata Takamitsu , Hosomi Koichi , Tani Naoki , Khoo Hui Ming , Oshino Satoru , Kishima Haruhiko
Published: August 2023

BACKGROUND

High-resolution computed tomography (CT), outfitted with a 0.25-mm detector, has superior capability for identifying microscopic anatomical structures compared to conventional CT. This study describes the use of high-resolution computed tomography angiography (CTA) for preoperative microvascular decompression (MVD) assessment and explores the potential effectiveness of three-dimensional (3D) image fusion with magnetic resonance imaging (MRI) by comparing it with traditional imaging methods.

OBSERVATIONS

Four patients who had undergone preoperative high-resolution CTA and MRI for MVD at Osaka University Hospital between December 2020 and March 2022 were included in this study. The 3D-reconstructed images and intraoperative findings were compared. One patient underwent conventional CTA, thus allowing for a comparison between high-resolution and conventional CTA in terms of radiation exposure and vascular delineation. Preoperative simulations reflected the intraoperative findings for all cases; small vessel compression of the nerve was identified preoperatively in two cases.

LESSONS

Compared with conventional CTA, high-resolution CTA showed superior vascular delineation with no significant change in radiation exposure. The use of high-resolution CTA with reconstructed 3D fusion images can help to simulate prior MVD. Knowing the location of the nerves and blood vessels can perioperatively guide neurosurgeons.
MAKNA TARIAN SIALO PADA RITUAL RAMBU SOLO LUWU SULAWESI SELATAN
Authors: Palanta Harlin , Tampake Tony
Published: August 2023

This research discusses the meaning of sialo dance. Sialo dance is one of the traditions of the Bastem Luwu community in South Sulawesi which is performed at the death ceremony (rambu solo). Understanding the values and meanings contained in sialo dances is often neglected and lack of concern, including the millennial generation not understanding and not knowing the values and meanings of sialo dances contained therein. The focus of this research explores the meanings contained in the sialo dance at the rambu solo ceremony from the perspective of the sociology of local culture. this writing is useful to increase knowledge about the culture of Luwu South Sulawesi.The author uses qualitative method research realist ethnographic approach to describe the meanings of interaction and cultural values of sialo dance. The author's local cultural sociology study uses the perspective of Herbert Mead's thinking, Herbert Blumer, Clifford Geertz with the perspective of symbolic interactionism studies. The research location is Lalong Village, Luwu Regency, Walenrang District, South Sulawesi. This writing is focused on exploring the meanings and values of the sialo dance which is the local culture of the Bastem community at the rambu solo ceremony. The results of this study indicate the meaning of the sialo dance, which is meaningful to tell the life history of the deceased person who was celebrated. In addition, this dance also has a meaning to welcome government guests who come to share grief with the deceased family.
Analisis Konsep Fisika Osilasi Terkopel pada Sistem Pegas Bermassa
Authors: Fatihah Nurul , Nurul Khomsati Nikma , Sahda Widyadhari Talitha , Nur Aziz Khafidh
Published: August 2023

Penelitian ini bertujuan untuk menentukan frekuensi harmonik pada sistem pegas terkopel serta mengetahui pengaruh variasi massa terhadap frekuensi  harmonik pada sistem pegas terkopel yang disusun seri dan paralel. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif eksperimental. Data yang diambil untuk dianalisis berdasarkan percobaan secara langsung di Laboratorium Fisika Dasar Universitas Negeri Yogyakarta. Hasil penelitian menunjukkan Frekuensi harmonik pada rangkaian seri berturut-turut adalah 1,29 Hz; 1,25 Hz; 1,05 Hz; 1,04 Hz; 0,94 Hz; 0,86 Hz; 0,81 Hz sedangkan pada rangkaian paralel 2,71 Hz;  2,50 Hz; 2,23 Hz; 1,92 Hz; 1,84 Hz; 1,75 Hz; 1,61 Hz. Massa mempengaruhi nilai frekuensi yang dihasilkan. Semakin besar massa, maka frekuensi yang dihasilkan semakin kecil.
PENGARUH SUHU PADA PROSES PENGENDAPAN SANTAN KELAPA DALAM PEMBUATAN VIRGIN COCONUT OIL (VCO)
Authors: Rahmawati Rahmawati , Agustrian
Published: August 2023

Indonesia is one of the large and wide countries that has a tropical climate because it is located on the equator. So that there is a lot of diversity of plants that live in tropical areas, namely coconut plants. The coconut fruit can be used as a variety of processed products, one of which is coconut oil. This study aims to analyze the effect of temperature on the deposition of coconut milk in the manufacture of Virgin Coconut Oil (VCO) to determine the value of density, viscosity, aroma, color, and flavor. This research was conducted at the Biology Laboratory of the University of PGRI Palembang in June 2022. The method used in this research is the experimental method. Data collection was carried out in the Biology Laboratory and then data testing was carried out in the Lab. Sriwijaya State Polytechnic Chemical Engineering. The results showed that for the coconut oil sample at a temperature of 800C the density value was 0.918 or 0.92 gr/cm3 according to the SNI standard density in the range of 0.91-0.92 gr/ml, viscosity value 57.26 mPa.s, oil color clear coconut, the characteristic aroma of coconut oil, and the tasteless taste. As for the temperature of 1000C, the density value is 0.92 gr/cm3 based on the SNI standard (Firdausi et al., 2008), the viscosity value is 63.83 mPa.s, the color of the coconut oil is clear, the distinctive aroma of coconut oil, the tasteless taste is according to the SNI 7381 standard:2005 (Alamsyah, 2005). From the results of the study it is said that temperature affects the process of making coconut oil.
PERCEPÇÃO SOBRE A GESTÃO FINANCEIRA EM EMPRESAS DO SETOR DO AGRONEGÓCIO
Authors: Fernanda Pereira de Araújo  , Maria Juliete Lopez Gabriel  , Geison Calyo Varela de Melo  , Ítalo Carlos Soares do Nascimento  , Jerferson Freitas da Silva
Published: August 2023

O presente estudo objetiva analisar a percepção sobre a gestão financeira em empresas do setor do agronegócio, visto que a gestão é fator primordial para as empresas que visam crescimento e oportunidades no mercado. Para desenvolver o estudo, o método escolhido baseia-se no modelo descritivo, quantitativo, utilizando um questionário e aplicado a dez colaboradores de empresas agrícolas do interior da cidade de Mossoró/RN. Pelos dados obtidos, foi possível se concretizar a importância da gestão financeira e das ferramentas utilizadas pela mesma para organização e crescimento da empresa. Desse modo, concluiu-se que o estudo alcançou o objetivo proposto, pois contextualizou a gestão financeira e o agronegócio, bem como a associação de ambos, e como essa associação se mostra para os colaboradores. Notou-se ainda que tanto conforme a literatura, quanto conforme os participantes a gestão financeira tem muita a somar nas empresas, especialmente no ramo agrícola, propondo organização, reduções de impostos quando legalmente disponível e facilidades para a administração das empresas.
EMPREENDEDORISMO E CONTABILIDADE: gestão de MPE’S
Authors: Ana Clara Aquino Nolasco  , Erivânio da Silva Dunga  , Antônio Gustavo Nicácio
Published: August 2023

As últimas décadas têm sido férteis de avanços tecnológicos, mudanças sociais, reorganização política, as quais incidem no cenário econômico e nas profissões que nele atuam. Considerando a rápida velocidade das informações e a forma como a economia se encontra mundialmente entrelaçada, o processo de tomada de decisões deve acontecer de forma certeira. Caso contrário, a empresa poderá cair no abismo do prejuízo. Compreender o funcionamento de uma empresa não se resume aos valores de entradas e saídas. Sua condução não deve acontecer apenas de forma intuitiva. E sim, suscita de um profissional que detenha preparo teórico e prático esteja presente, de maneira a possibilitar orientações e até mesmo, prever e evitar ameaças. Nessa direção, a pesquisa em tela tem como objetivo analisar a percepção dos empresários de pequeno e médio porte da cidade de Tibau-RN quanto a contabilidade. Para tanto, foram respondidos 18 questionários cujos resultados obtidos na pesquisa, que de modo quantitativo e descritivo, em síntese, apontaram que a maioria dos empresários utiliza um software integrado de gestão; e contam com a apoio de um contador de forma externa a empresa. Todavia, os dados revelaram que ainda se faz necessário conhecer melhor quais atribuições podem ser desenvolvidas pelo profissional e nesse aspecto, espera-se que a pesquisa possa trazer a contribuição de dar mais visibilidade à importância de uma empresa contar com as orientações de um contador não apenas para cumprir com as burocracias, e sim, no processo de tomada de decisões.
Ogólnopolska Konferencja Naukowa „Katolickie zasady relacji Państwo-Kościół a prawo polskie”. Warszawa, 20 maja 2015 roku
Authors: Kukulski Andrzej
Published: August 2023

Dnia 20 maja 2015 r. w auli Jana Pawła II Uniwersytetu Kardynała Stefana Wyszyńskiego w Warszawie odbyła się Ogólnopolska Konferencja Naukowa pt. „Katolickie zasady relacji państwo-Kościół a prawo polskie”, której organizatorami byli: UKSW w Warszawie, Wydział Prawa Kanonicznego UKSW i Stowarzyszenie Kanonistów Polskich. Konferencja zorganizowana została pod patronatem Jego Magnificencji Rektora UKSW, ks. prof. dr hab. Stanisława Dziekańskiego.
Ś.p. Ks. dr Bolesław Cieślak (1936-2014)
Authors: Witczak Henryk
Published: August 2023

Klerycy idący na wykłady, często dzielili się z kolegami informacjami, z kim mają zajęcia i gdy ktoś oznajmiał, że idzie na wykłady z „Aniołkiem”, nie było wątpliwości, że pytany będzie miał zajęcia z ks. prałatem Bolesławem Cieślakiem. Podobnie, jak wielu innym rocznikom kapłanów przypadło mi być studentem ks. Bolesława, ale też moim udziałem było i to, że stałem się jego następcą w parafii św. Jana we Włocławku. Mając świadomość kontrowersji, które związane były z jego osobą, zapewne w wielu przypadkach wynikające z jego pracy w Kurii Diecezjalnej, podjąłem się napisania tego wspomnienia starając się opierać jedynie na dokumentach znajdujących się w jego teczce osobowej. Trzeba więc powiedzieć, że jest to bardziej wspomnienie studenta o swoim profesorze.
Ś.p. Biskup dr Sofroniusz Mudry (1923-2014)
Authors: Kvasniy Victor Vasyl
Published: August 2023

Biskup Sofroniusz Mudry urodził się 27 listopada 1923 r. w Złoczowie na Ukrainie. Został ochrzczony jako Szczepan-Bazyl. W 1938 r. ukończył w Złoczowie szkolę narodową. W czasie drugiej wojny światowej wyemigrował do Niemiec, gdzie zamieszkał w obozie dla uchodźców. Pracował na budowie szańców. Po wojnie ukończył w Niemczech Instytut Elektrotechniczny w Augsburgu, został inżynierem-elektrykiem.
Ś.p. Ks. Infułat dr Stanisław Cały (1921-2013)
Authors: Słowikowska Anna
Published: August 2023

Ks. Stanisław Cały urodził się 5 marca 19 21 r. w Rzęsnej Polskiej k. Lwowa. Święcenia kapłańskie przyjął po ukończeniu czwartego roku kursu seminaryjnego w 1945 r. z rąk abpa Eugeniusza Baziaka we Lwowie. Ze względu na likwidację lwowskiego seminarium duchownego, formację dokończył w Kalwarii Zebrzydowskiej.
Sprawozdanie z Konferencji Naukowej Życie i działalność profesorów Katolickiego Uniwersytetu Lubelskiego Romana Longchamps de Bérier i Zdzisława Papierkowskiego oraz spotkania opłatkowego Stowarzyszenia. Lublin, 14 stycznia 2012 roku
Authors: Lewicka Mariola
Published: August 2023

Problematyka działalności naukowej, dydaktycznej i organizacyjnej profesorów Katolickiego Uniwersytetu Lubelskiego Romana Longchamps de Bérier i Zdzisława Papierkowskiego była przedmiotem konferencji naukowej połączonej ze spotkaniem opłatkowym Stowarzyszenia Absolwentów i Przyjaciół Wydziału Prawa KUL. Konferencję, która odbyła się w Lublinie dnia 14 stycznia 2012 r. zorganizowało: Stowarzyszenie Absolwentów i Przyjaciół Wydziału Prawa Katolickiego Uniwersytetu Lubelskiej, Katedra Kościelnego Prawa Publicznego i Konstytucyjnego KUL.
Sprawozdanie z absolutorium Wydziału Prawa, Prawa Kanonicznego i Administracji. Lublin, 27 czerwca 2012 roku
Authors: Zając Paweł
Published: August 2023

Dnia 27 czerwca 2012 r. na Wydziale Prawa, Prawa Kanonicznego i Administracji Katolickiego Uniwersytetu Lubelskiego Jana Pawła II, odbyła się po raz trzeci uroczystość zakończenia studiów połączona z wręczeniem wyróżnień i dyplomów Absolwentom poszczególnych kierunków studiów stacjonarnych (prawa, prawa kanonicznego, administracji i europeistyki). Organizatorami tego wydarzenia byli: Dziekan Wydziału Prawa, Prawa Kanonicznego i Administracji KUL, Stowarzyszenie Absolwentów i Przyjaciół Wydziału Prawa KUL oraz Samorząd Studentów Wydziału Prawa, Prawa Kanonicznego i Administracji KUL wraz z Opiekunami poszczególnych kierunków.
Is it true that treatment in patients with Subaxial Cervical Spine Injury Classification System (SLICS) 4 is the surgeon’s choice?
Authors: Kang Jung Hoon , Im Soo Bin , Kim Ju Hyung , Jeong Je Hoon
Published: August 2023

BACKGROUND: The Subaxial Cervical Spine Injury Classification System (SLICS) is a commonly used algorithm for diagnosing and managing subaxial cervical spine trauma. A SLIC score 4 suggests either surgery or non-surgically treatment depending on the surgeon’s experience and patient’s conditions. OBJECTIVE: Prognosis and treatment results were analyzed in patients with SLIC score 4. METHODS: The patients with SLIC score 4 were retrospectively reviewed from 2012 to 2019. Forty-one patients were included and divided into two groups: non-surgically treated and surgically treated. Demographic data and radiographs were analyzed. Statistical analysis was performed to determine the difference between the two clinical groups. RESULTS: Twenty-two patients were non-surgically treated, and nineteen patients were surgically treated. There was no neurological deterioration in both groups. However, there was no statistically significant difference in the last follow-up AISA and Nurick grade (p> 0.05). There was no significant difference in the number of patients who showed improvement when comparing the initial and the last follow-up neurological status (p> 0.05). CONCLUSION: Regardless of the treatment method, the spinal cord injury patients with SLICS point 4 showed a relatively good prognosis. Patients with SLIC score 4 could be treated non-surgically or surgically based on the surgeon’s experience and factors associated with the patient’s acute health status and chronic comorbidities.
Real time ultrasound imaging shows changes in deep neck flexor activation during exercise in individuals with mechanical neck pain
Authors: Daly Emily , Prodoehl Janey
Published: August 2023

BACKGROUND: Deep neck flexor muscle atrophy and increased superficial neck muscle activation are associated with disability and pain intensity in individuals with neck pain. There is a lack of evidence to support direct assessment of deep neck flexor muscles in a non-invasive way during exercise performance to help determine the effectiveness of different neck strengthening exercises. OBJECTIVE: Compare longus colli (LC) and sternocleidomastoid (SCM) activation between individuals with and without neck pain using real time ultrasound (RTUS) during a series of craniocervical exercises. METHODS: This cross-sectional cohort study recruited 10 control and 10 neck pain participants to complete four deep neck flexor activation activities involving varying levels of craniocervical flexion. Dimensions of the LC and SCM were measured using RTUS at rest and during exercise. Independent t-tests assessed baseline differences and analysis of variance examined activation changes. RESULTS: At rest, the neck pain group had significantly smaller cross-sectional area and thickness of the LC compared to the control group (p< 0.05). During exercise, the neck pain group showed significantly larger increases in LC thickness and cross-sectional area across exercise compared to the control group, with no differences in SCM activation between groups. CONCLUSIONS: Despite atrophy, individuals with neck pain can activate their deep neck flexor muscles appropriately without activating their superficial neck flexor muscles in a supine series of craniocervical flexion exercise as measured by non-invasive ultrasound imaging.
A certificateless signcryption with proxy-encryption for securing agricultural data in the cloud
Authors: Obiri Isaac Amankona , Addobea Abigail Akosua , Affum Eric , Ankamah Jacob , Kwansah Ansah Albert Kofi
Published: August 2023

Precision agriculture (PA) involves collecting, processing, and analyzing datasets in agriculture for an informed decision. Due to the high data storage and application maintenance costs, farmers usually outsource their agricultural data obtained from PA to cloud service providers to leverage cloud services. Nonetheless, serious security concerns arise from using cloud services for farmers. For instance, an attacker can intercept agricultural data and run comprehensive statistical analyses to adjudicate farmers’ financial status, extort money, commit identity theft, etc. As a result, compelling data security schemes have become crucial for secure precision farming, where only legitimate users are required to access the agricultural data outsourced to the cloud. This article presents a certificateless signcryption scheme with proxy re-encryption (CLS-PRE) for secure access control in PA. An in-depth security analysis proves that the CLS-PRE scheme is secure in the Random Oracle Model. Detailed performance evaluation also shows that the scheme can reduce the time required to signcrypt and unsigncrypt messages and lower communication overhead.
Fair and stable matching decision-making with multiple hesitant fuzzy elements
Authors: Yue Qi , Deng Zhibin , Hu Bin , Tao Yuan
Published: August 2023

The two-sided matching (TSM) decision-making is an interdisciplinary research field encompassing management science, behavioral science, and computer science, which are widely applied in various industries and everyday life, generating significant economic and social value. However, in the decision-making process of real-world TSM, the complexity of the decision-making problem and environment lead to the preference information provided by the two-sided agents being ambiguous and uncertain. The purpose of this study is to develop a new fair and stable matching methodology to resolve the TSM problem with multiple hesitant fuzzy element (HFE) information. The decision-making process is as follows. First, the TSM problem with four kinds of HFEs is described. To solve this problem, the HFE value of each index is normalized and then is transformed into the closeness degree by using the bidirectional projection technology. Second, based on the closeness degree, the weight of each index is calculated by using the Critic method. Then, the agent satisfaction is obtained by aggregating the closeness and the weights. Next, a fair and stable TSM model to maximizing agent satisfactions under the constraints of one-to-one stable matching is constructed. The best TSM scheme can be obtained by solving the TSM model. Finally, an example of logistics technology cooperation is provided to verify the effectiveness and feasibility of the presented model and methodology. The proposed methodology develops a novel fuzzy information presentation tool and constructs a TSM model considering the fairness and stability, which is of great significance to investigate the TSM decision-making and the resolution of real-life TSM problems under the uncertain and fuzzy environments. One future research direction is to consider multiple psychological and behavioral factors of two-sided agents in TSM problems.
The m6A reader HNRNPC predicts adverse prognosis and promotes the progression of colorectal cancer
Authors: Yu Yong Ming , Hu Yang
Published: August 2023

BACKGROUND: As a critical m6A RNA methylation regulator, HNRNPC has been revealed to serve as potential biomarkers in various human cancers. The specific expression and significance of HNRNPC in colorectal cancer remain unknown. OBJECTIVE: This study aimed to confirm HNRNPC expression level and evaluate its function in colorectal cancer progression. METHODS: 101 paired tissue samples were collected from colorectal cancer patients. HNRNPC levels in colorectal cancer were detected using PCR. CCK8 and transwell assays were conducted to estimate the effect of HNRNPC on cell growth and metastasis with the regulation of HNRNPC by cell transfection. RESULTS: Upregulated HNRNPC was observed in colorectal cancer compared with normal tissues and cells. The higher HNRNPC levels in tumor tissues were associated with the advanced TNM stage and positive lymph node metastasis. Meanwhile, HNRNPC upregulation could indicate adverse outcomes of colorectal cancer patients. In vitro, the knockdown of HNRNPC significantly suppressed the proliferation, migration, and invasion of colorectal cancer cells. CONCLUSIONS: Upregulated HNRNPC served as a biomarker for the prognosis and development of colorectal cancer, which provides a novel therapeutic target for colorectal cancer.
Test suite optimization under multi-objective constraints for software fault detection and localization: Hybrid optimization based model
Authors: Freeda R Adline , Rajendran P Selvi
Published: August 2023

Testing and debugging have been the most significant steps of software development since it is tricky for engineers to create error-free software. Software testing takes place after coding with the goal of finding flaws. If errors are found, debugging would be done to identify the source of the errors so that they may be fixed. Detecting as well as locating defects are thus two essential stages in the creation of software. We have created a unique approach with the following two working phases to generate a minimized test suite that is capable of both detecting and localizing faults. In the initial test suite minimization process, the cases were generated and minimized based on the objectives such as D-score and coverage by the utilization of the proposed Blue Monkey Customized Black Widow (BMCBW) algorithm. After this test suite minimization, the fault validation is done which includes the process of fault detection and localization. For this fault validation, we have utilized an improved Long Short-Term Memory (LSTM). At 90% of the learning rate the accuracy of the presented work is 0.97%, 2.20%, 2.52%, 0.97% and 2.81% is better than the other extant models like AOA, COOT, BES, BMO and BWO methods. The results obtained proved that our Blue Monkey Customized Black Widow Optimization-based fault detection and localization approach can provide superior outcomes.
PAIN WITH A NEUROPATHIC COMPONENT IN COMBATANTS AFTER GUNSHOT WOUNDS
Authors: Horoshko V.R. , Kuchyn Iu.L.
Published: August 2023

Background. In combatants with gunshot wounds, the frequency of pain chronicization is observed in 63.4-78.5% of cases. The reason for this high frequency of chronicization may be a neuropathic component. However, this hypothesis remains unexplored.

Aim: To study the frequency of neuropathic pain in combatants after gunshot wounds.

Materials and methods. We analyzed the treatment of 769 combatants after gunshot wounds. The neuropathic component of pain was identified using the Douleur Neuropathique 4 questions. The statistical analysis was performed using the Shapiro-Wilk, Friedman, chi-square, and Bonferroni correction.

Results. The obtained data indicate that all combatants with chronic pain after gunshot wounds have a neuropathic component of pain (DN4 - from 4 to 5 points). Moreover, the results between the groups did not differ after 1 month - p=0.918, and after 3 months - 0.713, 6 months - p=0.824 and 12 months - p=0.911.

Conclusion. Combatants who sustained gunshot wounds have a high risk of chronic pain. It was found that the neuropathic component of pain is present in all patients in this category, so it may be one of the key components of such a high frequency of pain chronicity, which requires further research.
ANALYSIS OF PROVIDED MEDICAL SERVICES IN THE MEDICAL GUARANTEES PROGRAM PACKAGE «CHEMOTHERAPY TREATMENT AND MAINTENANCE OF ADULTS AND CHILDREN WITH ONCOLOGICAL DISEASES IN OUTPATIENT AND INPATIENT SETTINGS»
Authors: Husak N.B. , Zub V.О. , Kotuza A.S.
Published: August 2023

Background. The approaches to the criteria for assigning a treated case/interaction to the "Oncology" package and the principles of their payment introduced in the National Health Service of Ukraine need to be optimized in order to prevent the risks of introducing inadequate rates, namely: not providing services for the amount specified in the rate and double/triple funding.

Aim: to investigate and identify the main defects and gaps in the existing U-Grouper rules regarding the assignment of a treated case/interaction to a package in the field of "Oncology" and to develop recommendations for improving the existing U-Grouper rules in this field based on the findings.

Materials and methods. A single descriptive-analytical study of the analysis of medical services provided in the oncology package 17 "Chemotherapy treatment and maintenance of adults and children with oncological diseases in outpatient and inpatient settings" for the first 8 months of 2022 in Ukraine was performed. Statistical methods, structural-logical analysis and systematic approach were used.

Results. The study found certain gaps in the coding of diagnoses under the diagnostically related group "R63 Chemotherapy", one of which is the incorrect coding of the main diagnosis during chemotherapy treatment, as only 20% of all Electronic Medical Records (EMRs) had the main diagnosis coded according to the Australian coding system (code Z51.1). Incorrect coding of oncological diseases was also detected, which may contribute to an increase in the payment of the case. Thus, in just 8 months of 2022, 19,368 interactions were registered, of which 35.7% (6,923) were without additional diagnoses, i.e., payment was made for such EMRs without clear criteria for the presence of a malignant neoplasm, which contradicts the requirements of the 17th package.

Conclusions. Based on the findings, it is proposed to make changes to the Medical Guarantees Program in the field of "Oncology" and to introduce automatic medical monitoring of EMRs, in which the main diagnosis of certain categories of classes C and D is coded, which will allow to bring the medical services provided to patients with oncohematological diseases into compliance with the rate.
SOME ASPECTS OF THE ETIOLOGY, PREVALENCE AND DIAGNOSIS OF THE TEMPOROMANDIBULAR JOINT DYSFUNCTION (A REVIEW)
Authors: Bezkorovaina L.P. , Zhehulovych Z.Ye.
Published: August 2023

Background.Temporomandibular joint diseases (TMJ) occupy a special place among dental diseases due to the complexity of the clinical picture which often depends on within the professional competence of doctors of various specialties - otolaryngologists, neurologists, psychiatrists, rheumatologists, diseases whose complicate diagnosis and treatment. Painful TMJ dysfunction is a common disease that leads the patient to the dentist.

Aim: to analyze modern publications devoted to the problem of pain dysfunction of the temporomandibular joint in terms of causes and diagnostic methods related to practical dentistry.

Materials and methods. An analysis of data obtained during an information search in the online databases "PubMed", "SciELO", "Medcape" and "Science of Ukraine: access to knowledge" and official web-sites of Ukrainian education and scientific institutions was carried out using the keywords "pain dysfunction", "Costen's syndrome", "musculofascial syndrome", "temporomandibular joint".

Results. Today, TMJ dysfunction is an unsolved problem of practical dentistry which has a significant number of points of contact with other specialties. The pain and psycho-emotional component of this disease can be a significant problem for the patient and negatively affect his quality of life. The complex etio-pathogenesis of TMJ dysfunction and confusing classification of conditions leads to frequent assumptions of diagnostic and treatment mistakes of dentists and other specialists. Today, further development and improvement of diagnosis and treatment methods of patients with TMJ dysfunction, including the development and modification of diagnostic protocols and expanding indications for the use of modern highly informative diagnostic methods. Quite often the rehabilitation of such a patient requires a team approach and may last for years.

Conclusion. The organization of diagnosis, treatment and follow-up of patients with painful TMJ dysfunction needs further improvement and research.
Phylogenetic Evidence for the Early Origin of the Homeostatic Influence of the Biota on Planetary-Scale Geophysical Processes
Authors: Leggett Mark , Ball David A.
Published: August 2023

This paper uses empirical evidence to address the subject of when and how Gaia arose. To set the scene for this, the paper first proposes two core necessary attributes for Gaia: each individual having control systems and joint action of groups of such individuals producing results that are more beneficial to the group than would have arisen from the isolated action of each individual. We make the case that the predominantly recognised “planetary” nature of Gaia is a contingent rather than necessary attribute. The paper next identifies representative examples in contemporary organisms of each of the two core attributes of Gaia in operation. For each of these examples, genes making up part of the genetic specification of the example were identified. We then sought these same genes in the earliest examples of life that have been genetically characterised in empirical terms - the Last Universal Common Ancestor (LUCA) and the Last Bacterial Common Ancestor (LBCA). These arose respectively between 4 and 3.5 billion years ago. Examining both the pools of known modern genes and demonstrated LUCA and/or LBCA genes, sufficient relevant modern genes were also found in LBCA and/or LUCA to provide empirical evidence that the core attributes of Gaia were present in LBCA and/or LUCA. Hence, we claim that the first Gaia likewise arose between 3.5 to 4 billion years ago. The paper also provides case studies showing similar results at increasing scales of organismal aggregation over the intervening period to the present.
Fear Factors in Open Spaces – Children’s Perception of Public Open Spaces
Authors: Chandwania Dhruv , Natu Abhijit
Published: August 2023

The world is undergoing rapid urbanization, where it is presumed that by 2050, almost 66% of the children’s population will be found in cities. The well-being of children is associated with their day-to-day surrounding environment, which includes their home, school, and recreational spaces. Children’s active participation in open spaces is critically necessary for their physical, social, emotional, and cognitive well-being. Urbanization is putting pressure on the quality and quantity of open spaces, where crowding, maintenance, and stranger-danger are persistent concerns of the parents for their children’s outdoor play experience. A survey was conducted in the city of Pune with 105 children, studying their perception and use of open space. Children were asked to prepare cognitive maps indicating fearing factors and/or elements found in the open spaces which they visit regularly. Children indicated various fearing factors like strangers, unclean surroundings, diagrams related to the upkeep of various elements in open spaces. The coding of the diagrams indicated concerns related to safety from crime, injury from harmful elements, wayfinding, etc. The perception of children was analyzed using qualitative methods. Further, the paper discusses the fear factors associated with open space aspects like design, aesthetics, density, accessibility, traffic, etc., which contribute to children’s perception of open spaces, thus affecting children’s independent mobility, the choice of the space of play, and the amount of time spent during outdoor play. Getting parental license to go outdoors was related to the Natural surveillance available, and the fear factors were found to be related to the space management aspects like fencing, maintenance, and also security in case of strangers present in the spaces.
Influence of Allergy, Asthma Treatment(AT) and Eviction Diet(ED) on Sleep-Disordered Breathing(SDB) in Pediatric Asthma Associated With Osa, Increased Respiratory Effort(RE) During Sleep and Overweight/Obesity: a Study in 78 Children
Authors: Kefala Kalomoira , Guerin Philippe
Published: August 2023

Pathophysiological mechanisms and allergies in Obstructive Sleep Apnoea-asthma associated are unclear. Apnoea hypopnea Index alone does not seem sufficient to correctly guide for adequate treatment without identification of the specific profile of each patient. Obstructive Sleep Apnoea correlates to obesity; however, links between obesity, allergy, and Obstructive Sleep Apnoea remain unexplored. Obese allergic children with Obstructive Sleep Apnoea increase their Body Mass Index despite adequate weight interventions.

We aimed to study the Respiratory Polygraphy/Polysomnography profile of children suffering Obstructive Sleep Apnoea-asthma associated and the influence of allergies and Asthma Treatment/Eviction Diet upon Apnoea Hypopnea Index/Respiratory Effort/Body Mass Index to diagnose, treat and prevent pediatric Obstructive Sleep Apnoea-asthma associated and related obesity early and accurately.

We effectuated a cross-sectional/case controls diagnostic cohort. We used Receiver Operating Characteristic curves, General Linear Models, regression, and path analysis to evaluate the effect of treatments and allergies on Apnoea Hypopnea Index, Respiratory Effort, Body Mass Index and Polygraphy/Polysomnography parameters such as Respiratory Distress Index, Sleep Fragmentation, Sleep Fragmentation Ventilatory Origin, Oxygen Desaturation Index.

We identified that asthma treatment and specific allergen eviction, along with the co-existence of non-IgE-mediated and respiratory allergies, influence the Apnoea Hypopnea Index, Respiratory Effort during sleep and the Body Mass Index.

Allergies, asthma treatment and allergen eviction are implicated in the pathophysiological mechanisms of Obstructive Sleep Apnoea and obesity. Consideration of asthma treatment, allergies, and allergen eviction upon interpretation of polygraphy/polysomnography parameters could ameliorate the diagnosis and treatment of Obstructive Sleep Apnoea-asthma associated and possibly avoid, upon their origin, asthma, and obesity.
Collective Guilt and the Search for Meaning in Post-Communist Albania: An Existential Perspective
Authors: Musaj Ledion , Dema Anxhelo
Published: August 2023

This study explores the experiences of individuals who have lived through the post-communist transition in Albania, focusing on their sense of existential collective guilt and their coping mechanisms through meaning-making processes. Twenty written narratives were collected and analyzed, revealing a strong sense of collective guilt related to the communist past, with participants feeling responsible for the harm caused by the regime. The interplay between collective guilt and meaning-making mechanisms was observed as complex, with collective guilt often acting as a barrier but also providing motivation for effective meaning-making. In general, this study emphasizes how crucial appreciating these processes can be, both on personal levels and collective ones, when striving to move beyond the heritage of the past and create a better future. Furthermore, we delved into an analysis of the strengths and limitations of the study, which are also discussed in this paper.
Sobre la necesidad de criminalizar la difusión no consentida de registros con contenido sexual
Authors: Javier Javier
Published: August 2023

La difusión no consentida de registros con contenido sexual, obtenidos o producidos con el consentimiento de la víctima, es un fenómeno que ha aumentado en las últimas décadas. ¿Qué respuesta contempla el Derecho Penal chileno para este tipo de casos? El presente trabajo tiene por finalidad demostrar, a través del análisis de distintos tipos penales, que actualmente los casos de difusión no consentida de registros con contenido sexual no reciben una respuesta penal adecuada en Chile, a pesar de que la intervención del Derecho Penal se encuentra plenamente justificada en atención a los daños que genera en las víctimas este fenómeno. Debido a lo anterior, se argumentará que el legislador chileno debiese criminalizar la difusión no consentida de registros con contenido sexual mediante la incorporación de un tipo penal especial, siguiendo la actual tendencia en el derecho comparado.
Penentuan Konsentrasi Peg Untuk Seleksi Toleransi Kekeringan Pada Fase Benih Menggunakan 3 Varietas Cabai Lokal Sumatera Barat
Authors: Budiyanti Tri , Indriyani NLP , Kirana Rinda , Suliansyah Irfan , Hervani Dini
Published: August 2023

Abstrak PEG sering dipergunakan untuk seleksi toleransi cekaman kekeringan pada fase perkecambahan benih. Selain itu PEG juga dapat berguna untuk osmoticum priming karena bersifat inert secara kimiawi dan tidak menimbulkan efek merusak pada embrio benih. Penelitian ini bertujuan untuk mengetahui konsentrasi kritis pemberian poly ethylene glycol (PEG 6000) yang menyebabkan penurunan perkecambahan benih 3 varietas cabai local Sumatera Barat sehingga dapat dipergunakan untk skrening toleransi kekeringan genotipe cabai pada fase perkecambahan. Penelitian  ini menggunakan Rancangan Acak Lengkap 2 faktor. Faktor pertama adalah 3 varietas cabai yaitu Cabai Lontabar,  Kopay dan Aka. Faktor kedua  terdiri dari 6 perlakuan konsentrasi PEG yaitu 0%, 5%, 10%, 15%,20% dan 25 %. Hasil penelitian menunjukkan konsentrasi PEG 15% menyebabkan penurunan perkecambahan 3 varietas cabai asal Sumatera Barat. Pada konsentrasi 20% benih cabai sudah tidak berkecambah. Oleh karena itu untuk skrining toleransi kekeringan dapat menggunakan konsentrasi PEG 15% sehingga proses seleksi lebih efektif dan efisien. Kata kunci : Cabai, seleksi, PEG, toleran kekeringan
ANALISIS KERAGAMAN GEN PROLAKTIN (PRL) PADA ITIK PITALAH; ITIK LOKAL SUMATERA BARAT
Authors: Amelia Riska , Rusfidra Rusfidra , Subekti Kusnadidi , Arlina Firda , Husmaini Husmaini , Haryati Stefani Fitri
Published: August 2023

AbstrakProlaktin merupakan hormon polipeptida yang disekresikan oleh kelenjar pituitary anterior dan secara spesifik kandidat gen yang mengontrol variasi jumlah produksi telur dengan reduksi biosintesis telur dalam beberapa periode mengeram. Tujuan penelitian ini  adalah untuk menganalisis keragaman gen Prolaktin pada itik Pitalah. Ekstraksi yang dilakukan pada sampel darah 45 ekor itik Pitalah dengan menggunakan protocol G-spinTM Total DNA Extraction Mini Kit dari Intron Biotechnology. Selanjutnya diamplifikasi dengan menggunakan sepasang primer forward 5’- CTG CAT CTG TGG ACA TTG CT-3’ dan reverse 5’GAA GCA GGT TTG GGA GTA CG-3’ dengan target fragmen 496 bp dan disekuensing menggunakan jasa 1sr Base Singapore. Data hasil sekuensing dianalisis menggunakan Seqmen DNASTAR dan MEGA 11 dan menunjukkan 14 keragaman pada daerah ekson 4 dan parsial intron 3 dan 4 pada titik mutasi INDEL 3703A, INDEL3939A, C3974A, A4030G, A4038C, T4056C, G4061A, T4091G, T4094A, T4098C, G4102A, C4106A, A4107C dan C4154G. Keragaman gen Prolaktin bersifat polimorfik dengan frekuensi genotype tidak dalam keseimbangan Hardy-Weinberg. Kata Kunci: Prolaktin, Itik Pitalah, Keragaman, Mutasi, Mutasi, Sekuensing
COST MANAGEMENT OF THE LIFE CYCLE OF REAL ESTATE OBJECTS: EXPERIENCE, PROBLEMS AND SOLUTIONS
Authors: Popovychenko Iryna , Levchinskiy Dmytro , Kirnos Оlesya
Published: August 2023

The authors of the article address the international experience of implementation and use of the concept of evaluation and cost management of Life Cycle Costing (LCC) and Whole Life Appraisal (WLA) of real estate objects. The author’s interpretation of the issues and ways of introduction of this concept in developing countries, in particular in Ukraine, is presented. The article describes the tools and forms of public-private partnership for implementing this concept in the practice of effective functioning of socio-economic systems. Specifics of the managing life cycle costing of real estate objects basing on such approaches/ methods as development, maintenance, surveying, and concession are determined. The paper emphasizes the practical significance for all interested parties in the real estate development market of using methods of a comprehensive and systematic approach to the integrated evaluation of assets in the process of their design, construction, operation, and maintenance. The authors focus on the need for comprehensive accounting of the costs of the whole life cycle of a product (both construction products in the form of buildings and structures, and any high-tech products with a long life cycle from its design to disposal). Notable cost management methods (Kaizen Costing, Standard Costing, and Target costing) are considered, as a significant component of the LCC/WLA concept the development. The authors analyse the role of corporate investment funds, joint investment institutions, professional associations, and asset management companies in the implementation of the LCC/WLA concept in the field of real estate development. The respective statistical data (from Ukrainian practical experience) that can be used to prognosticate the impact of inflation in the construction industry are cited. The significance of database digitalization and BIM technologies in the introduction of the regarded concepts in the practice of construction and development activities is stressed.