bluuebunny/crossref_metadata_2025 huggingface dataset:
PERBANDINGAN PENERAPAN METODE PENGAMANAN MOD SECURITY DAN MOD EVASIVE PADA WEB SERVER TERHADAP SERANGAN SLOW HEADERS
Authors: Pahlawan Panca Putra
Published: October 2023

Perkembangan teknologi informasi semakin cepat dengan adanya internet, teknologi ini juga telah merambah ke dunia pendidikan, yaitu dengan adanya sistem pembelajaran daring (SPADA) atau pembelajaran jarak jauh (PJJ), yang diselenggarakan dan diatur dalam Permenristekdikti. Dalam penerapan teknologi tersebut dibutuhkan Web Server yang dapat berjalan dengan baik ketika pembelajaran sedang berlangsung. Menjaga keamanan Web Server dari berbagai gangguan atau serangan menjadi hal yang penting. Salah satu jenis serangan yang dapat terjadi adalah DoS Attack yaitu Slow Headers. Untuk mengatasi jenis serangan tersebut ada beberapa macam metode pengamanan yang dapat digunakan, diantaranya yaitu metode Mod Security dan metode Mod Evasive. Untuk mengetahui metode pengamanan terbaik dalam mengatasi serangan Slow Headers penulis melakukan penelitian mengenai pengujian dan analisa perbandingan dari penerapan metode Mod Security dan Mod Evasive terhadap serangan Slow Headers pada pengkondisian (state) sistem Web Server universitas xyz. Hasil dari penelitian yang telah dilakukan, mengenai penerapan pengamanan yang lebih baik dalam menangani serangan Slow Headers, dapat disimpulkan bahwa metode pengamanan yang lebih baik, yang telah diterapkan adalah Mod Security. Mod Security dapat melakukan pemblokiran permintaan walaupun permintaan yang dilakukan tidak utuh, dan dapat mempertahankan halaman situs pada Web Server agar tetap diakses oleh Client, sedangkan Mod Evasive tidak dapat melakukan hal tersebut.
ANALISIS KINERJA JARINGAN WIRELESS LAN MENGGUNAKAN METODE QOS (QUALITY OF SERVICE) DI PERPUSTAKAAN SMK NEGERI 5 BANDAR LAMPUNG
Authors: Rachmadi Tri Rachmadi
Published: October 2023

Teknologi jaringan komputer menjadi hal yang sangat penting karena banyaknya kelebihan yang dimiliki antara lain mudah dan efisien. Namun demikian perlu adanya kinerja jaringan komputer yang mumpuni agar manfaatnya dapat dirasakan secara maksimal. Pada jaringan wireless lan perpustakaan SMKN 5 digunakan untuk mengirim dan menerima file berupa gambar, audio, video, akses data dan mencari e-book, sehingga dibutuhkan kualitas jaringan yang baik, maka perlu dilakukan analisis kinerja jaringan pada perpustakaan.Penelitian ini akan menganalisis jaringan wireless lan perpustakaan dengan menggunakan metode QoS (Quality of Service) dan perangkat lunak axence nettools 5 dan wireshark dengan cara melakukan penerapan bandwidth unlimated dan bandwidth diatur, pembebanan 6 laptop tekoneksi kejaringan perpustakaan dan melakukan pengiriman paket dengan ukuran yang telah ditetapkan.Hasil pengukuran yang didapatkan selanjutnya akan diolah untuk dianalisis nilai bandwidth, delay, jitter, packet loss dan throughput digunakan untuk mengetahui bagaimana kualitas wireless lan yang disediakan. Berikut hasil yang telah didapatkan untuk nilai terbaik pengujian pertama tanpa beban nilai bandwidth 32Mbps, nilai delay 31ms, nilai jitter 13,80ms, nilai packet loss 11 %, nilai throughput 1175Kbps, pengujian kedua penerapan bandwidth unlimated nilai bandwidth 30Mbps, nilai delay 8,12ms, nilai jitter 19,74ms, nilai packet loss 0%, nilai throughput 1161Kbps, pengujian ketiga penerapan 1Mbps untuk setiap user, bandwidth 1,68Mbps, nilai delay 1,89ms, nilai jitter 38,49ms, nilai packet loss 1,5%, nilai throughput 3448Kbps, dengan hasil yang diperoleh untuk jaringan wireless diperpustakaan termasuk kategori bagus menurut standarisasi versi TIPHON.
PREDIKSI JARAK TEMPUH KAPAL MOTOR SANGIANG MENGGUNAKAN SUPERVISED MACHINE LEARNING
Authors: Rio Afrioni Roma , Siahaan Berton Maruli
Published: October 2023

As a maritime nation with thousands of islands and a vast sea area, sea transportation is the most effective transportation used by the people of Indonesia. A motorboat is one type of maritime transportation that is used to move people or commodities. In this article, we will discuss predicting the daily mileage of one of the motorboats, the Sangiang, which travels from Bitung to Ternate. Three independent variables, Anchor Time (minutes), Speed (knots/hour), and Sailing Time (minutes), are used in supervised machine learning techniques to estimate the daily mileage (mile). Of the various methods evaluated, the multiple regression model was found to be the most accurate at forecasting the Sangiang motorboat’s daily mileage.
ANALISA KERENTANAN WEBSITE FMIPA UNSRAT BERDASARKAN OPEN WEB APPLICATION SECURITY PROJECT TOP 10 FRAMEWORK
Authors: Soewoeh Christian Alderi Jeffta , Tenda Edwin , Ketaren Eliasta , Kalengkongan Wisard Widsli , Takaendengan Mahardika Inra
Published: October 2023

Salah satu langkah preventif untuk meminimalisir dampak buruk serangan siber adalah dengan melakukan penilaian kerentanan yang hasilnya dapat dianalisa sesuai framework OWASP Top 10. Menurut hasil monitoring keamanan siber BSSN tahun 2021 menunjukkan bahwa serangan siber pada sektor pendidikan tinggi semakin meningkat. Oleh karena itu, penting bagi institusi pendidikan tinggi seperti FMIPA UNSRAT untuk meningkatkan keamanan siber mereka dan memperkuat perlindungan infrastruktur informasi vital mereka. Dengan mengikuti rekomendasi yang diberikan dalam penelitian ini, diharapakan dapat membantu FMIPA UNSRAT dalam meningkatkan perlindungan  keamanan website dan mencegah serangan siber yang dapat membahayakan informasi penting mereka.
APLIKASI PEMBELAJARAN SEJARAH PAHLAWAN INDONESIA DI WILAYAH SUMATERA (STUDI KASUS SDN 2 SUMBEREJO)
Authors: Musthofa Zacky
Published: October 2023

Learning systems that are still conventional make students easily feel bored and bored in learning because the learning system is monotonous. Many teachers experience difficulties in educating their students to be able to understand and understand the material being explained. The benefit of this research is to increase students' interest in learning and make it easier for teachers to teach. As well as reminding and informing the public of the services of Indonesian Heroes. At the same time encouraging innovation and creativity from teachers in teaching the values of the history of Indonesian heroes that are conducive to students, by adding learning media interactive learning media. Applications can be continued because the application is feasible with a total calculation of 100% of application eligibility. Testing this application was carried out as many as 11 test actions. Where there are no error messages or function errors being tested.
Flavonoids from Impatiens grandulifera and Their Antioxidant Activity
Authors: Whaley A. K. , Lukashov R. I. , Whaley A. O. , Zhokhova E. V. , Gurina N. S. , Goncharov M. U. , Yakovlev G. P. , Tsiarletskaya V. A.
Published: October 2023

Introduction. The genus Impatiens L. includes about 850 species, which are found mainly in tropical and subtropical climate zones. The Indigenous people of Pakistan used pastes and extracts from I. glandulifera for the treatment of joint pain, anxiety and skin allergies [6]. Flowers of I. glandulifera are used in Bach flower remedies, which are used for sedation, relaxation and helping to balance emotional states.

Aim. Isolation and structural elucidation of 11 phenolic constituents from the aerial parts of I. glandulifera and the evaluation of their antioxidant activity.

Materials and methods. The aerial part of Impatiens glandulifera Royle was collected in the Leningrad region near the village of Orekhovo in 2021. Fractions were analyzed by analytical high performance liquid chromatography (HPLC) using a Prominence LC-20 (Shimadzu, Japan) equipped with a diode array detector. The isolation of individual compounds was carried out by column chromatography on open glass columns with sorbents of different selectivity, as well as by preparative HPLC using a Smartlina (Knauer, Germany) equipped with a spectrophotometric detector. The structure of isolated individual compounds was established by 1D and 2D NMR spectroscopy (Bruker Avance III 400 MHz, Germany). To study the antioxidant activity, we used solutions obtained by dissolving the isolated substances in a mixture of dimethyl sulfoxide and ethanol; an aqueous solution of vitamin C and an alcoholic solution of Trolox (Sigma-Aldrich, Japan).

Result and discussion. Phytochemical analysis of the aerial parts of Impatiens glandulifera Royle. resulted in the isolation of 11 polyphenolic secondary metabolites (1-11) and their structures were elucidated. The antioxidant activity of all isolated compounds was evaluated.

Conclusion. The maximum RAP values of eriodyctiol (3), kaempferol (1), and quercetin (2) did not differ significantly (p = 0.585) from those of the comparator preparations: vitamin C and Trolox, which indicates that the antioxidant effect of these three isolated compounds is comparable to the well-known antioxidants. However, the semi-effective concentrations of these substances are two or more times lower (p = 2.56 · 10–4) comparted with vitamin C.
Wolman’s Disease and GNE Myopathy Frequency to Religion
Authors: J Jackson , R Turner , K Yukutake , E Baghdasaryan , E St. Denis , T Barseghyan , S Begaj , M Pietruszka , Y Valles-Ayoub
Published: October 2023

Complete absence or deficiency of Lysosomal acid lipase (LAL) leads to the rare infantile disorder Wolman's Disease [1]. Decreased function of GNE can lead to GNE myopathy [2]. Although both pathological phenotypes are rare, LAL deficiency only affects 1 in every 500,000 births and dysfunction of GNE affects 1 in every 1,000,000 births, there is a higher incidence in the religious groups of the Middle East; the incidence is projected to be as high as 1 in every 4,200 births [3,4]. The LIPA gene encodes for LAL while the GNE gene encodes for UDPN- acetylglucosamine (GlcNAc) 2-epimerase/N-acetylmannosamine (ManNAc) kinase [4,5]. LAL catalyzes the hydrolysis of cholesterol esters and triglycerides [6]. GlcNAc and ManNAc are responsible for the biosynthesis of sialic acid [7]. Presence of variations in GNE genes are known to impair the enzymes and lead to pathological phenotypes. This study reports the prevalence of mutations c.260G>T; p.G87V and c.894G>A; E8SJM in the lipase gene (LIPA) and c.2228T>C p.M743T in GNE gene amongst different religions. We sequenced 1,354 samples for the presence of the variations in LIPA exon 4 and 8 along with GNE exon 13(formerly exon 12). The sample population comprised individuals of varying Middle Eastern religions such as Mizrahi Jewish, Muslims, Christians, Baha’i, Catholic, Buddhist and Zoroastrian. The other religions that were not Mizrahi Jewish were classified under “Non-Jewish” to have a more even distribution. LIPA gene exon 4 variation p.G87V had a heterozygous frequency of 22 in 1,354(1.62%) with 20 of 22(90.9%) heterozygotes being Mizrahi Jewish while 2 of 22(9.09%) heterozygotes were Non-Jewish. Exon 8 splice junction mutation E8SJM, G>A transition at position 1 had a frequency of 2 in 1,354 (0.14%) with 2 of 2(100%) heterozygotes being Mizrahi Jewish. GNE exon 13 variation p.M743T (formerly exon 12 p.M712T) had a mutation frequency of 58 in 1,354(4.28%) with 5 of these 58(8.62%) samples being homozygous while 53 of the 58(91.37%) were heterozygous. In 58 samples that yielded a mutation, 54 of them were Mizarhi jewish (93.1%).
Socialization of Making Organic Fertilizer to Increase Plant Productivity in the Banjarsari Village Community Ngajum Malang Regency
Authors: Laili Saimul
Published: October 2023

The aim of this outreach is to educate the public that organic waste and animal waste have been very useful waste, for example as fertilizer but are rarely used due to lack of knowledge about it and the manufacturing process. Therefore, by providing socialization about making fertilizer from organic waste and animal waste, it can increase the added value of organic waste and animal waste and help the community increase plant productivity. Organic fertilizer is very good for plants because it can provide nutrients for plants. Its use can simultaneously loosen barren soil, increase porosity, aeration and the composition of microorganisms in the soil. Organic fertilizer is also useful for increasing the soil's water holding capacity so that it can store ground water longer. The process of making organic fertilizer can be done by decomposing or fermenting organic waste by planting it in a hole in the ground or a large pot and then filling it with soil, then the organic waste will naturally turn into organic fertilizer. Keyword: Organic Fertilizer, Garbage Animal Waste, Agricultural Pants
Study Of Diversity And Distribution Of Wild Plant In Corn (Zea mays) And Sugar Sugar (Saccharum officinarum) Fields In Gondanglegi District, Malang Regency
Authors: Laili Alvi Nur , Hayati Ari , Zayadi Hasan
Published: October 2023

The existence of wild plants causes competition between the main plants and wild plants. Wild plants that grow with cultivated plants can reduce yields, both in quality and quantity. This study aims to determine the species diversity and distribution of wild plants in maize (Zea mays) and sugarcane (Saccharum officinarum) fields in Gondanglegi District, Malang Regency. This research method is descriptive and exploratory. The data measured included the number of species, the number of individuals, the importance value index, and the diversity index of wild plant species. The results showed that there were 19 species of maize in all villages and the number of individuals was found (3395 individuals). In the sugar cane fields, 17 species were found in three villages in the Godanglegi Sub-District which found the number of individuals (2254 individuals). The distribution value of wild plants on corn fields in Sumberjaya, Ganjaran, and Putatlor villages is quite high with an average percentage of 65.3% higher than wild plants on sugar cane fields with an average percentage of 46.4%.Keywords: Corn, Sugarcane. Wild Plants
Isolasi dan Identifikasi Awal Bakteri Patogen pada Kolam Maturasi IPLT Supit Urang Kota Malang
Authors: Rahmadani Arninda Fadila , Faisal Faisal , Ramadhan Majida , Prasetyo Hamdani Dwi
Published: October 2023

The sanitation problem in Malang City is a serious problem. The Supit Urang Fecal Sludge Treatment Plant (IPLT) is intended to improve the processing of fecal waste so that is suitable for disposal into the environment. This study aims to isolate and identifyx the initial types of pathogenic bacteria contained in fecal waste effluent found in maturation ponds. The method used is descriptive exploratory xto provide an overview of the presence of pathogenic bacteria in maturation ponds. The data obtained was then analyzed descriptively in form of data tabulations in tables and diagrams. The result showed that there were four genera of pathogenic bacteria identified in maturation ponds. The four genera are xmembers of the Enterobacteriaceae family, including Escherichia, Salmonella, Klebsiella, and Enterobacter. Microscopically, bacteria were found to be gram-negative with bacilli, cocci, and spiral cell shapes. The presence of pathogenic bacteria in the maturation ponds is thought to be due to thex depth of the pond and the detention time exceeds the standard. Treatment of fecal waste in maturation ponds is not optimal because it still contains harmful pathogenic bacteria, so it needs more intensive processing to make it suitable for disposal into the river.Keywords: fecal sludge, IPLT, maturation pond, pathogenic bacteria
LOKALİZE MEME KANSERİ TEDAVİLERİNDE EFEKTİF İLAÇ TAŞIYICI SİSTEMLER: ENJEKTABL HİDROJELLER
Authors: KONCA Süheyl Furkan , ÖZ Umut Can , BOZKIR Asuman
Published: October 2023

Amaç: Meme kanseri dünya genelinde kadınlarda en sık gözlenen kanser türü olup, erken teşhis ve etkili tedavi stratejilerinin geliştirilmesi için sürekli araştırmaların yapılmasını gerektiren kritik bir sağlık sorunudur. Geleneksel kemoterapi uygulamalarındaki spesifik olmayan hedefleme, sistemik toksisite, ilaç direnci, kısıtlı ilaç penetrasyonu gibi sınırlamaların aşılmasında yenilikçi tedavi yöntemlerinin geliştirilmesine ihtiyaç duyulmaktadır. İlaç taşıyıcı sistemler olarak enjektabl hidrojeller biyoparçalanır, biyouyumlu, tasarıma yönelik ayarlanabilir fizikokimyasal özelliklerinin yanı sıra etkin maddenin yüksek verimlilikte yüklenmesini ve salımını sağlayabilmesi dolayısıyla lokal kanser tedavilerinde ön plana çıkmaktadır. Enjektabl biyoparçalanır hidrojeller özellikle cerrahi sonrası tedavi sürecinde tümör nüksünü ve metastazını önlemede kritik öneme sahiptir. Bu derlemede enjektabl hidrojellerin yapıları, türleri, kanser tedavilerine ilişkin uygulamaları ve antikanser tedavi etkinliklerinin değerlendirilmesi amaçlanmıştır.
Sonuç ve Tartışma: Bu derlemede farmasötik ilaç taşıyıcı sistemler olarak enjektabl hidrojel yapıları, meme kanseri tedavilerine ilişkin uygulamaları ve meme kanserine yönelik antikanser tedavi etkinlikleri ele alınmıştır.
ANALYSIS OF LIGHTNING INTERFERENCE ON THE 500 KV DEPOK-TASIK TRANSMISSION TOWER
Authors: Wulandari Rindi
Published: October 2023

Lightning is a natural phenomenon that can cause damage to transmission lines and cause disturbances in the distribution of electrical energy. Indonesia is a country with a high density of lightning strike in tropical areas such as in Java Island (Indonesia). The 500 kV Depok-Tasik transmission tower is part of the West Java interconnection. This transmission is 142 kms away and is supported by a tower of 340 units (tower 326-666), this transmission uses dual channels. This study aims to analyze and determine the method of lightning protection and to determine the magnitude of the voltage arising from a lightning strike in the 500kV transmission tower Depok-Tasik in order to be able to see the transmission parameters of the lightning density map, the trend of the time of the strike and the peak current frequency of the overvoltage caused by the lightning strike by analyzed using software falls. Software falls is a lightning analysis software used to study the relationship between lightning events and geographically referenced assets. Anomaly data on the 500kV Depok-Tasik conductor in 2021-2022 occurred 12 times, disturbances occurred 6 times in 2021 and 6 disturbances occurred in 2022, this can be a reference for asset inventory in the future.
Manastırlı Kadınların Kullandıkları Ev Tekstilleri (1700-1730)
Authors: KOÇAK Zülfiye
Published: October 2023

Maddi kültür unsurlarından olan ve bir milletin örf ve adetlerinin önemli göstergeleri arasında yer alan ev ve eşya kültürü, tarihsel süreç içerisinde toplumdan topluma değişiklik göstermiştir. Bu yönüyle kadınların evlerde kullandıkları tekstiller ve bunların yapımında kullanılan kumaşlar toplumun sosyo-ekonomik ve sosyo-kültürel yapısını belirlemede etkili olmuşlardır. Tarihte birçok medeniyete ev sahipliği yapmış olan Manastır, I. Murat zamanında Osmanlı egemenliğine alınmıştı. 18. Yüzyıla gelindiğinde nüfusun çoğunluğunu Müslümanların oluşturduğu şehirde halkın hukuksal sorunlarını çözen Osmanlı kadısı aynı zamanda dava kayıtlarını da tutturmuştu. Şer‘iyye Sicilleri adıyla anılan bu kayıtlar, Manastır’ın hukuksal ve sosyal yapısını aydınlatacak bilgilerin yanı sıra ölen kişilerden kalan miras ayrıntıları hakkında da önemli ipuçları sunmaktadırlar. Ölen kişilerin miras paylaşımlarının yer aldığı defterlere; tereke, ya da kassam defterleri denilmektedir. Kadı ve kassamlar tarafından yapılan miras dağılımı, müstakil kassam defterlerine kaydedildiği gibi şer‘iyye sicillerine de kaydedilebilirdi. Şer‘iyye sicillerine kaydedilen bu türden belgelerde ölen kişinin taşınır-taşınmaz tüm malları, her türlü alacak-verecek ilişkilerine dair bütün bilgiler yer almaktadır. Dolayısıyla bu defterlerden hareketle bir toplumun maddi kültür unsurlarından olan ev tekstilleri hakkında bilgi edinmek mümkündür. Bu çalışmada 1700-1730 yılları arasında Manastır mahkemesinde tutulmuş 14 adet şer‘iyye sicil defterlerinde dağınık halde bulunan 98 kadın terekesi incelenmiş ve bunlardan hareketle şehirde kadınlar tarafından kullanılan ev tekstillerinin neler olduğu, hangi malzemelerden yapıldıkları, fiyatları ve bunların kadınların servet ve statülerine göre değişip değişmediği irdelenmiştir.
Sovyet Dış Politikasında Türkiye, Balkanlar ve Orta Doğu (1957-1960)
Authors: ÖZALPER Mehmet
Published: October 2023

Sovyet Rusya, bloklaşan dünyada doğu devletleri ile yakından ilgilenmiştir. Orta Doğu eksenli olmak kaydıyla bu ülkelerde yaşanan siyasi ve askeri bütün olaylar sürekli merkezinde yer almıştır. Balkan Politikasını da sabit tutan Sovyetler bu bölgenin kendisi için Avrupa’ya açılan tek kapı olması sebebi ile dış politikada Balkanlara özel bir yer ayırmıştır. Ortadoğu’da olduğu gibi Balkan ülkelerinin de iç ve dış politikalarını sürekli takip etmiş ve gerekli olduğunu hissettiği zaman müdahalelerde bulunmuştur. Türkiye’nin bir Balkan ülkesi olup olmadığı noktasında bilim camiasında çok farklı görüşler bulunmaktadır. Ancak gerek mirasını devraldığı Osmanlı Devleti’nin bütün idari sistemlerinin Balkanlarda oluşması gerekse de Avrupa kıtasına dolayısıyla Balkan coğrafyasına dahil olan ve dünya merkezi statüsündeki şehirlerin ilk sıralarında sayılan İstanbul’un içerisinde bulunduğu coğrafyanın Türkiye’de yer alması sebebiyle bir Balkan ülkesi olarak kabul edilebilmektedir. Sovyet Rusya’da bu sayılan sebeplerin de etkisiyle Türkiye ile olan ilişkilerinde tıpkı Orta Doğu ve Balkan ülkelerine davrandığı şekilde yaklaşımlar sergilemiştir. Özellikle İkinci Dünya Savaşı’ndan sonra değişen dünya konjonktürü ve Sovyetlerde yaşanan iktidar değişiklikleriyle Balkanlar, Türkiye ve Orta doğu ile alakalı konularda Sovyet Rusya’nın alakasının arttığı söylenebilir. Bu çalışmamızda bahsi yıllarda Sovyetlerin üç bölgeye karşı izlediği dış politika Tarih biliminin usul ve kaideleri çerçevesinde incelenmiştir.
Conceptual framework in the area of digital assets: issues and areas of development
Authors:   SESE “The Academy of Financial Management”, OLIYNYK Yana , KUCHERIAVYI Artem ,   SESE “The Academy of Financial Management”
Published: October 2023

Introduction. In recent years, the digital economy has become the main driver of economic growth both at the global and national levels. Within this paradigm, a number of socio-economic challenges are being overcome: creating new jobs, ensuring digital inclusion of people around the world. Problem Statement. The national institutional environment in the field of the digital economy is currently under development, in particular in terms of consistency of conceptual apparatus. The purpose of the article is to analyze the conceptual and categorical apparatus used in the regulatory and legal framework for accounting and taxation of objects arising from the activities of business entities in the digital economy, and to determine the directions of its development. Methods: institutional approach; comparative analysis; synthesis; hierarchical classification method. Results. A bibliographic analysis of scientific and professional publications showed that all categories of “non-fungible token”, “virtual asset”, “cryptoasset” are inherently digital assets, i.e. assets that are stored or transmitted in digital format and have economic or cultural value. The global nature of digital assets has led to the need for international coordination on their legal status and resolution mechanisms. Such digital assets as virtual assets, cryptoassets and their subtypes are regulated at different levels: international (FATF, OECD); regional (EU); national (UK, Ukraine). The presented review of the documents defining the concepts of “digital asset”, “cryptoasset” and “virtual asset” at the international and regional levels, as well as in individual countries, demonstrates that there is currently no generally accepted definition of these terms. Conclusions. The conducted study of the features in forming the conceptual and terminological apparatus of accounting and taxation of objects, the appearance of which is determined by the activities of economic entities under the digital economy, in regulatory documents at various levels showed that when developing institutional support for the regulation of the circulation of digital assets and operations with them in Ukraine the approach used by the FATF was chosen. In terms of its content, the category of “virtual assets” corresponds to the interpretation of the category of “cryptoassets” laid down by European legislation. The author identifies terminological inconsistencies in the Ukrainian legal framework that require further resolution through a cross-analysis of legislation to unify approaches to the interpretation of digital economy objects.
Pendampingan Perhitungan Unit Cost Di Lingkungan Rumah Sakit
Authors: Adam Helmy
Published: October 2023

This assistance aims to assist Menur Mental Hospital in calculating the unit cost in determining the rate of charge to patients in accordance with the actual service costs. The method used in this service is a case study with data collection methods in the form of observation through focus group discussions, interviews and documentation. The analysis used is quantitative based on data interpretation by delivering information in the form of texts and narratives. The analysis used or grand theory. Results of Community Service. From the results of the analysis, it is found that several things that need to be considered regarding unit cost calculations in RJS Menur are the establishment of standardization to determine direct and indirect costs that will be calculated in unit cost calculations. This is because there is still no standardization of quality, cost and so on which appears as one of the problems in the unit cost analysis process.
PENGEMBANGAN APLIKASI DAN PELATIHAN WHATSAPP BROADCASTER DI LEMBAGA KURSUS ABC CALISTUNG
Authors: Affandi Luqman , Ismail Ade , Wakhidah Rokhimatul , Sumari Arwin Datumaya Wahyudi , Hormansyah Dhebys Suryani
Published: October 2023

Implementation of Community Service activities with the title "Development of Whatsapp Broadcaster Applications and Training at the ABC Calistung Sidoarjo Course Institute" was carried out on March 1, 2021 to October 31, 2021. Meanwhile, the implementation of applications, training and mentoring was carried out online on July 27, 2021 The results that have been achieved in the implementation of this PkM are Services in the form of training and assistance in using the Whatsapp Broadcaster application, the product is in the form of the Whatsapp Broadcaster application that has been installed on partner servers, intellectual Property Rights in the form of Copyrights that are still in the form of a submission draft.
BIMBINGAN TEKNIS PEMBUATAN PUPUK CAIR DI DESA BINAAN POLINEMA, WRINGINSONGO – TUMPANG
Authors: Hadiantoro Sigit , Hardjono Hardjono , Suryandari Ade Sonya , Noor Isnaini Azkiya
Published: October 2023

Wringinsongo Village, Tumpang is an area that has enormous natural resource potential. The main livelihoods of the residents of Wringinsongo Village are farmers, working on plantations and also raising livestock. These three livelihoods produce various wastes that can be used as materials for making liquid fertilizer. Liquid fertilizer is a solution from the decay of organic materials derived from plant residues, animal waste, which contains more than one nutrient element. The best raw materials for liquid fertilizer are wet organic matter or organic materials that have a high water content, such as fruit and vegetable residues. This PPM program aims to help the assisted villagers in solving their problems by providing training on the manufacture of liquid fertilizer to utilize and reduce household waste in the assisted villages. The methods used in PPM activities are counseling, training and monitoring. The results of the PPM activity showed an increase in participants' knowledge and skills in making liquid fertilizer. Furthermore, several PPM achievements that have been achieved include: Articles published in national journals with ISSN, and publication of activities on social media.
PELATIHAN INSTALASI PENERANGAN SEL SURYA DI PEMANDIAN SUMBERWRINGIN
Authors: Rifai Mohamad , Astono Guntur Yanuar , Habibi Isac Ilham Akbar , Huda Miftakhul , Komarudin Achmad , Hariyadi Herman
Published: October 2023

Wringinsongo Village is one of Polinema's partner villages. Wringinsongo Village is located in Tumpang District. There is a lot of potential in Wriginsongo Village, including potential, fishery plantations, agriculture, and water resources. The local government of Malang Regency through Wringin Songo Village reads the situation as an opportunity to improve the welfare of its citizens. So that currently the spring functions as water tourism called Sumberwringin Baths which is managed by the village government as an attractive natural recreation facility. Sumberwringin bathhouse is a potential bathhouse to be developed by Wringin Songo village, but this bath is still lacking in terms of lighting. The manager wants to install lighting around the baths by utilizing natural resources, namely sunlight. Therefore, training in the use of sunlight (PLTS) for lighting and training on the maintenance of solar power plant equipment is needed
YIELD OF SHUTTLESS RUME DEPENDING FROM THE METHOD OF SOWING AND THE NORMS OF SOWING SEEDS
Authors: Timoshkin Oleg , Timoshkina Ol'ga , TRIShINA Varvara
Published: October 2023

In the conditions of the Penza region in 2021–2022 developed elements of the technology of a new variety of awnless brome Udalets when cultivated for seed purposes. We studied the sowing method (factor A) — a row at 15 cm (control) and a wide-row method with row spacings of 30 cm, 45 cm, 60 cm, as well as seeding rates (75; 90; 105; 120 plants per linear meter). According to the hydrothermal coefficient, the growing season of 2021 was characterized as dry (hydrothermal coefficient is equal to 0.8), 2022 — normal in terms of moisture supply (hydrothermal coefficient is equal to 1.0). In the year of using the herbage, the best indicators of the structure of the seed yield of awnless brome were obtained with a wide-row sowing method of 30 cm and a seeding rate of 3.50 million germinating seeds per 1 ha. At the same time, the number of productive stems was 106 pieces/m2, which is by 8.2 %; exceeds the control. The highest seed yield of awnless brome in the first year of use was formed with a wide-row sowing method at 30 cm — 824 kg/ha at a seeding rate of 3.50 million germinating seeds per 1 ha and 784 kg/ha at a sowing rate of 3.00 germinating seeds per 1 ha, the excess over the control (ordinary sowing method by 15 cm) was 106–146 kg/ha, or 15.6–21.5 %. With an ordinary method of sowing at 15 cm, a high yield was obtained in the control variant (6 million viable seeds/ha) — 678 kg/ha. With an increase or decrease in the seeding rate from the control, the seed yield decreased by 7.6–32.4 %.
CURRENT STATE, CHALLENGES AND PROSPECTS OF SCIENTIFIC RESEARCH OF AGRICULTURAL SCIENCE IN THE NORTH-WEST OF RUSSIA ON THE EXAMPLE OF THE KALININGRAD REGION
Authors: Zarudnyy Vladimir
Published: October 2023

The article presents an analysis of the development of the feed industry and current directions of scientific research on the example of the Kaliningrad region.
ALFALFA VARIETIES FOR THE NORTH OF THE NON-CHERNOZEM ZONE OF RUSSIA
Authors: Stepanova Galina
Published: October 2023

The V. R. Williams Federal Research Center "VIC" has created varieties of alfalfa of variable Lucy, Agnia VIC, Taisia for cultivation in the northern regions of the Non-Chernozem zone, which are characterized by sod-podzolic waterlogged soils with reduced biological activity and increased acidity. The new varieties have a higher resistance to cultivation conditions in the Non-Chernozem zone compared to the Vega 87 variety: the safety of the herbage in the fourth year of use was at the level of 92–98% against 70% of the Vega 87 variety. On average, over the four years of cultivation, the yield of new varieties was 58.1–64.7 t/ha of green mass, 16.6–17.8 t/ha of dry matter, which is 14–27 and 16–25% higher than the yield of Vega 87. The average seed harvest for four years of use reached 474–525 kg/ha, the yield of the Vega 87 variety was 376 kg/ha.
PROTEIN CONTENT IN PEA GRAIN AND PROTEIN COLLECTION FROM ONE HECTARE
Authors: BAYKALOVA Larisa , Serebrennikov Yuriy
Published: October 2023

The article provides results of research protein content and collection in grain of 12 varieties of seed peas. The yield studied varieties of seed peas mostly did not exceed 4.0 t/ha. The exception was the varieties Salamanka (4.6 t/ha) and Thomas (4.1 t/ha). Moreover Altayskiy usaty showed a close result (3.9 t/ha). On the protein content be in the leads according to the research results, the varieties Altayskiy usaty, Varyag, Radomir, Yakhont, Svetozar (more 24,0%). At Altayskiy usaty and Yakhont in the 2021 given parameter reached 26.0%. And the varieties Altaiskiy usaty, Radomir, Varyag the protein content on all 3 years was 25.0% and more. On the protein harvesting at best results at the varieties Salamanka, Altayskiy usaty, Thomas, Nordman (more 7.0 h/ha). On 2020–2021 at the varieties Altayskiy usaty, Salamanka and Thomas given parameter exceed 10.0 h/ha. And in 2021 at Salamanka the protein harvesting was 9.9 h/ha. The influence a temperature factor, also moisture availability on the protein content the greatest in second-third decades of May, also — in first decades of June. The greatest dependence at head supply and moisture availability it was detected in varieties Kemchug, Annushka, Radomir, and Salamanka. Hydrothermal coefficient rendered analogous influence on the investigated of varieties. But as stated above the varieties Kemchug, Annushka, Radomir, Salamanka in list most hydrothermal coefficient dependented of the varieties to get Varyag. Impact of meteorological factors on the protein harvesting generally was less strong. Annushka, Radomir, Yamalskiy, Yakhont, at the same time, showed the greatest dependence from air temperature, precipitations and hydrothermal coefficient.
Sérgio Abreu e Dona Monina: um duo além do Duo
Authors: Mourim Cabral Roberta
Published: October 2023

Este artigo é um desdobramento da tese “Monina Távora: a pedagogia de um artista”, defendida no PPGM/UNIRIO em 2022. Embora a pesquisa tenha se dado na linha de “Ensino e Aprendizagem em Música”, teve caráter inter/transdisciplinar, com intercessão com as áreas de musicologia e performance. Aqui, destaquei partes em que relatos de Sérgio Abreu foram utilizados para ajudar a contar a história de Adolfina Raitzin de Távora — ou Monina Távora — professora de violão e a pessoa responsável pela formação do Duo Abreu. A tese teve como fio condutor um documento autobiográfico deixado por Monina sob os cuidados de Sérgio Abreu. Através da análise desta fonte, sob a perspectiva do “paradigma indiciário”, pude inferir sobre as ideias de Dona Monina acerca da vida, da música e do violão. No presente trabalho, me propus a indicar possíveis apropriações de Sérgio das ideias de Monina em relação à performance.
Sérgio Abreu e o histórico de sua contribuição com Quaternaglia e Brazilian Guitar Quartet
Authors: Prada Teresinha , Peno Hoberdan
Published: October 2023

O brasileiro Sérgio Abreu (1948-2023) ficou conhecido como concertista internacional ao violão, nas décadas de 1960 e 1970, inicialmente no Duo Abreu, formado com seu irmão, Eduardo, e depois em uma breve carreira solo. Na sequência, a luteria firmou-se como sua principal atividade. Há menor atenção quanto a Sérgio Abreu na produção musical e, devido a isso, o presente texto tem como objetivo principal evidenciar qual foi sua experiência e contribuição de produtor junto a dois quartetos, o Quaternaglia e o Brazilian Guitar Quartet. O método histórico tentou se cercar de elementos que mostrassem as condições em que os dois grupos surgiram e o momento em que Sérgio Abreu foi procurado. De referenciais, utilizamos Morais (2007) que estudou transcrições de Sérgio Abreu, o livro biográfico de Dias (2015), revistas especializadas, coleta de dados em páginas dos grupos e contatos com integrantes dos quartetos, obtendo-se relatos especialmente para esse artigo.
Sérgio Abreu: os fundamentos de uma escola violonística
Authors: Morais Luciano
Published: October 2023

Este artigo investiga as possibilidades dentro das quais o trabalho interpretativo de Sérgio Abreu, especialmente como violonista, pode estruturar a fundamentação de uma escola violonística. É baseado em dados coletados em minha dissertação de mestrado, defendida em 2007, mas somente aqui estruturado em termos de 3 aspectos definidos como fundamento: sonoridade, ritmo e processos interpretativos. Contém uma breve análise da oscilação histórica das poéticas interpretativas e discute em que sentido a sistematização da poética interpretativa é um passo fundamental para a democratização do conhecimento a partir da Universidade como promotora de fundamentação crítica.
Seed treatment affected establishment and yield in two pennycress lines
Authors: Koirala Nasib , Barker David J. , Gesch Russ W. , Mohammed Yesuf Assen , Heller Nicholas J. , Hard Alexander W. , Wells Samantha S. , Phippen Winthrop B. , Tas Pamela , Lindsey Alexander J.
Published: October 2023

Introduction

Oilseed pennycress (Thlaspi arvense L.) is an emerging biofuel crop for use in the aviation industry that has potential as a rotational crop in corn (Zea mays L.)–soybean [Glycine max (L.) Merr.] cropping sequences. Ensuring autumn emergence of pennycress after early broadcast seeding is key because this practice may result in uneven spatial distribution due to the small seed size and variable germination, soil contact, and moisture availability. The objective of this research was to evaluate the impact of five seed treatments and enhancements on autumn establishment in two pennycress lines (MN106NS and tt8-t/ARV1) in broadcast seeding compared with no treatment.

Methods

Tested treatments were (i) gibberellic acid (GA) soak, (ii) fludioxonil fungicide, (iii) pelleting with diatomaceous earth and a commercial binder, (iv) fungicide plus pelleting, or (v) fungicide plus pelleting with GA added to the binder. Seeds were planted at nine sites in four U.S. states to assess establishment (stand counts and percentage canopy cover) in the autumn and spring and seed yield after maturity.

Results

The MN106NS line had greater plants m−2 and percent green cover with treatments that included GA compared to the control. Line tt8-t/ARV1 had reduced stands when pelleted compared to the untreated, and establishment was unchanged when treated with GA compared to the untreated. Pelleting treatments without GA were not beneficial for stand establishment of either line. Seed yield for MN106NS was 20% greater than the untreated when treated with GA only or pelleted. Seed yield for tt8-t/ARV1 did not increase over the untreated with any treatment and was reduced by 20%–40% when pelleted.

Discussion

These results suggest minimal benefit of seed treatment and pelleting for the tested lines under broadcast seeding, though black-seeded lines may still benefit from GA treatment. Plant establishment and yield were negatively correlated with total precipitation post-planting, suggesting that excessive rainfall post-planting (>60 mm) may impede establishment when broadcast seeded.
Secretome analysis of breast cancer cells to identify potential target proteins of Ipomoea turpethum extract-loaded nanoparticles in the tumor microenvironment
Authors: Swami Sanskriti , Mughees Mohd , Mangangcha Irengbam Rocky , Kauser Sana , Wajid Saima
Published: October 2023

Background: Breast cancer is the leading cause of frequent malignancy and morbidity among women across the globe, with an increment of 0.5% incidences every year. The deleterious effects of traditional treatment on off-target surrounding cells make it difficult to win the battle against breast cancer. Hence, an advancement in the therapeutic approach is crucial. Nanotechnology is one of the emerging methods for precise, targeted, and efficient drug delivery in cells. The previous study has demonstrated the cytotoxic effect of Ipomoea turpethum extract on breast cancer cells delivered via NIPAAM-VP-AA nanoparticles (NVA-IT). Manipulating the tumor microenvironment (TME) to inhibit cancer progression, invasion, and metastasis seems to be very insightful for researchers these days. With the help of secretome analysis of breast cancer cells after treatment with NVA-IT, we have tried to find out the possible TME manipulation achieved to favor a better prognosis of the disease.

Method: MCF-7 and MDA MB-231 cells were treated with the IC50 value of NVA-IT, and the medium was separated from the cells after 24 h of the treatment. Nano LCMS/MS analysis was performed to identify the secretory proteins in the media. Further bioinformatics tools like GENT2, GSCA, GeneCodis 4, and STRING were used to identify the key proteins and their interactions.

Result: From the nano LCMS/MS analysis, 70 differentially expressed secretory proteins in MCF-7 and 191 in MDA MB-231 were identified in the cell’s media. Fifteen key target proteins were filtered using bioinformatics analysis, and the interaction of proteins involved in vesicular trafficking, cell cycle checkpoints, and oxidative stress-related proteins was prominent.

Conclusion: This study concluded that I. turpethum extract-loaded NIPAAM-VP-AA nanoparticles alter the secretory proteins constituting the TME to cease cancer cell growth and metastasis.
Morphogenetic processes in the development and evolution of the arteries of the pharyngeal arches: their relations to congenital cardiovascular malformations
Authors: Graham Anthony , Hikspoors Jill P. J. M. , Lamers Wouter H. , Anderson Robert H. , Bamforth Simon D.
Published: October 2023

The heart and aortic arch arteries in amniotes form a double circulation, taking oxygenated blood from the heart to the body and deoxygenated blood to the lungs. These major vessels are formed in embryonic development from a series of paired and symmetrical arteries that undergo a complex remodelling process to form the asymmetric arch arteries in the adult. These embryonic arteries form in the pharyngeal arches, which are symmetrical bulges on the lateral surface of the head. The pharyngeal arches, and their associated arteries, are found in all classes of vertebrates, but the number varies, typically with the number of arches reducing through evolution. For example, jawed vertebrates have six pairs of pharyngeal arch arteries but amniotes, a clade of tetrapod vertebrates, have five pairs. This had led to the unusual numbering system attributed to each of the pharyngeal arch arteries in amniotes (1, 2, 3, 4, and 6). We, therefore, propose that these instead be given names to reflect the vessel: mandibular (1st), hyoid (2nd), carotid (3rd), aortic (4th) and pulmonary (most caudal). Aberrant arch artery formation or remodelling leads to life-threatening congenital cardiovascular malformations, such as interruption of the aortic arch, cervical origin of arteries, and vascular rings. We discuss why an alleged fifth arch artery has erroneously been used to interpret congenital cardiac lesions, which are better explained as abnormal collateral channels, or remodelling of the aortic sac.
Scalable expansion of human pluripotent stem cells under suspension culture condition with human platelet lysate supplementation
Authors: Yuan Haitao , Su Hong , Wu Chen , Ji Yibing , Zhou Lili , Wang Lingna , Zhang Haihong , Zhang Xin , Tian Xiaopeng , Zhu Fangfang
Published: October 2023

The large-scale production of human pluripotent stem cells (hPSCs), including both embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs), shows potential for advancing the translational realization of hPSC technology. Among multiple cell culture methods, suspension culture, also known as three-dimensional (3D) culture, stands out as a promising method to fulfill the large-scale production requirements. Under this 3D culture condition, cell expansion and the preservation of pluripotency and identity during long-term culture heavily relies on the culture medium. However, the xenogeneic supplements in culture medium remains an obstacle for the translation of cell and gene therapy applications from bench to bedside. Here, we tested human platelet lysate (hPL), a xeno-free and serum-free biological material, as a supplement in the 3D culture of hPSCs. We observed reduced intercellular variability and enhanced proliferation in both hESC and hiPSC lines. These cells, after extended culture in the hPL-supplemented system, maintained pluripotency marker expression, the capacity to differentiate into cells of all three germ layers, and normal karyotype, confirming the practicability and safety of hPL supplementation. Furthermore, through RNA-sequencing analysis, we found an upregulation of genes associated with cell cycle regulations in hPL-treated cells, consistent with the improved cellular division efficiency. Taken together, our findings underscore the potential of hPL as a xeno-free and serum-free supplement for the large-scale production of hPSCs, which holds promise for advancing clinical applications of these cells.
P53 independent pathogenic mechanisms contribute to BubR1 microcephaly
Authors: Sterling Noelle A. , Terry Bethany K. , McDonnell Julia M. , Kim Seonhee
Published: October 2023

The mosaic variegated aneuploidy (MVA)-associated gene Budding Uninhibited by Benzimidazole 1B (BUB1B) encodes BUBR1, a core member of the spindle assembly checkpoint complex that ensures kinetochore-spindle attachment for faithful chromosome segregation. BUB1B mutation in humans and its deletion in mice cause microcephaly. In the absence of BubR1 in mice, massive cell death reduces cortical cells during neurogenesis. However, the molecular and cellular mechanisms triggering cell death are unknown. In this study, we performed three-dimensional imaging analysis of mitotic BubR1-deficient neural progenitors in a murine model to show profound chromosomal segregation defects and structural abnormalities. Chromosomal defects and accompanying DNA damage result in P53 activation and apoptotic cell death in BubR1 mutants. To test whether the P53 cell death pathway is responsible for cortical cell loss, we co-deleted Trp53 in BubR1-deficient cortices. Remarkably, we discovered that residual apoptotic cell death remains in double mutants lacking P53, suggesting P53-independent apoptosis. Furthermore, the minimal rescue of cortical size and cortical neuron numbers in double mutant mice suggests the compelling extent of alternative death mechanisms in the absence of P53. This study demonstrates a potential pathogenic mechanism for microcephaly in MVA patients and uncovers the existence of powerful means of eliminating unfit cells even when the P53 death pathway is disabled.