bluuebunny/crossref_metadata_2025 huggingface dataset:
Contribution to the Protonemura Kempny, 1898 (Plecoptera: Nemouridae) of the Caucasus
Authors: MURÁNYI DÁVID , MANKO PETER , KOVÁCS TIBOR , VINÇON GILLES , ŽIAK MATEJ
Published: July 2023

New records of Protonemura species are enumerated on the basis of specimens collected between 2015 and 2019 in the Greater and Lesser Caucasus. Three new species are proposed on the basis of males, females and nymphs: P. apetor sp. n. from Georgia, P. boris sp. n. from Azerbaijan and Georgia, and P. soad sp. n. from Armenia and Georgia. Comments are given on the variability of the adults of P. spinulata Martynov, 1928 and P. viridis Balinsky, 1950 on the basis of Azerbaijani and Georgian specimens. The hitherto unknown nymph of P. aculeata Theischinger, 1976, P. bacurianica bacurianica Zhiltzova, 1957, P. oreas Martynov, 1928, P. spinulata and P. viridis are described on the basis of association by pharate adults. Protonemura spinulata is new for Armenia, P. triangulata Martynov, 1928 is new for the Lesser Caucasus, and Nemoura dromokeryx Theischinger, 1976 is new for Georgia and the Caucasus. A checklist of the Protonemura species known from Anatolia, the Caucasus, the Alborz and the Levant is presented.
Proceedings of the 2022 XVI International Conference On Ephemeroptera and XX International Symposium On Plecoptera (Table of Contents)
Authors: DEWALT R. EDWARD , BURIAN STEVEN K.
Published: July 2023

Proceedings of the 2022 XVI International Conference On Ephemeroptera and XX International Symposium On Plecoptera (Table of Contents)
Preface: Proceedings of the XVIth International Conference on Ephemeroptera and XXth International Symposium on Plecoptera
Authors: DEWALT R. EDWARD , BURIAN STEVEN
Published: July 2023

Because of uncertainty about hosting an international, in-person conference in mid-2021, our meeting was postponed until summer 2022. Uncertainty continued into 2022. We could not wait longer, so The Joint Meeting of the XVI International Conference on Ephemeroptera and XX International Symposium on Plecoptera was a virtual affair hosted from the University of Illinois Urbana Champaign, U.S.A. The conference occurred daily, 0600–0900 hrs Chicago time, 26–29 July 2022. Despite the virtual venue, 41 oral (video) and 26 poster presentations were given by a total of 133 authors, representing 28 countries. At least 196 unique persons attended the 12 hrs of conference. It was a surprisingly successful meeting. The meeting program and links to all presentations are available from Plecoptera Species File. There were no Lifetime Achievement Awards bestowed upon our members during this meeting. A proposal for a meeting in 2024 in Turin, Italy was presented and accepted. In the weeks following the conference, we learned of the tragic death of our good friend and colleague Dr. Boris C. Kondratieff. We dedicate this volume to his memory and provide an obituary in this volume.
Description of Adults of Acentrella nadineae McCafferty, Waltz & Webb, 2009 (Baetidae: Ephemeroptera) with notes on rearing and madicolous behavior of nymphs
Authors: BURIAN STEVEN K.
Published: July 2023

Acentrella nadineae McCafferty, Waltz, & Webb, 2009 is broadly distributed in cool, clean, swift rocky streams across parts of the southeast, northeast, and midwestern United States, but currently its adult stages are unknown. The difficulty associated with successfully rearing nymphs of Acentrella species is mostly responsible for our lack of knowledge of adult life stages. New field observations of A. nadineae nymphs from the Hubbard River, Massachusetts, USA were used to modify an already successful rearing system for baetid nymphs to obtain a reared series of male and female imagos for study. Both life stages were photographed alive and are described herein for the first time. In addition, details of the modified rearing system and notes on the unusual madicolous behavior of near final instar nymphs are presented.
Factors structuring patterns of Ephemeroptera (mayflies) species assemblages in different segments of the Western Ghats of peninsular India—a snapshot
Authors: SIVARAMAKRISHNAN K. G. , SELVAKUMAR C. , VASANTH M. , SUBRAMANIAN K. A.
Published: July 2023

Species assemblage patterns of the mayflies (Ephemeroptera) in different segments of the Western Ghats (WG) of peninsular India including those on “sky islands” are presented. An updated checklist of species of WG mayflies is provided and sorted by traits of individual species and supplemented by personal observations. Comparisons are made in this context with patterns of current distribution of some ancient lineages of myriapods, amphibians and birds from the WG focusing on relative roles of geographical barriers (gaps), paleoclimatic, eco-evolutionary scenarios and anthropogenic impacts. This is to highlight the need to prioritize conservation of this rapidly shrinking precious biological heritage. Future work on molecular aspects of intra- and interspecific diversity of mayflies, which are “sentinels of inland water ecosystem health” should be augmented in tune with current research trends in montane “sky islands” especially from adjacent Oriental tropics.
Complexities in comparing the impact of costimulatory domains on approved CD19 CAR functionality
Authors: Smith Richard , Shen Rhine
Published: July 2023

Chimeric antigen receptors (CARs) are engineered to target T cells specifically to tumor cells, resulting in the engineered T cell killing the tumor cell. This technology has been developed to target a range of cancers, with the most notable successes in the treatment of B-cell malignancies where four approved therapies, all targeting CD19, are on the market. These four products differ in the costimulation domains, with axicabtagene ciloleucel (Yescarta) and brexucabtagene autoleucel (Tecartus) both utilizing the CD28 costimulation domain whilst tisagenlecleucel (Kymriah) and lisocabtagene maraleucel (Breyanzi) both utilizing the 4-1BB costimulation domain. There are clearly defined differences in how the CD28 and 4-1BB domains signal, yet it is difficult to ascertain which domain affords a superior mechanism of action given many other differences between these products, including overall CAR architecture and manufacturing methods. Additionally, while in vitro and preclinical in vivo studies have compared CARs with different costimulation domains, it remains a challenge to extrapolate differences observed in this biology across different experimental systems to the overall product performance. While there has been extensive preclinical and clinical work looking at CARs with a variety of targeting domains and architectures, this review will focus on the differences between the four marketed anti-CD19 CAR-Ts, with an additional focus on the impact of hinge and transmembrane domain on CAR activity and interaction with the target cell as well as other proteins on the surface of the T-cell.
Increased human immunodeficiency virus viral load with cerebral infarction due to varicella zoster virus vasculopathy on treatment with bictegravir/emtricitabine/tenofovir alafenamide suspension: a case report and literature review
Authors: Ishikawa Kazuhiro , Kawai Fujimi , Mori Nobuyoshi
Published: July 2023

Background

Varicella-Zoster virus (VZV) vasculopathy occasionally occurs in immunocompromised patients and is difficult to treat. The risk factor and optimal therapy remain unclear. Patients with human immunodeficiency virus (HIV) and dysphagia or difficulty in oral intake receive antiretroviral therapy (ART) suspension. However, there remains little evidence regarding ART suspension.

Case presentation

We experienced a case of a 55-year-old man diagnosed with HIV and severe multiple cerebral infarctions due to VZV vasculopathy. We started on bictegravir/tenofovir alafenamide/emtricitabine (BIC/TAF/FTC) and acyclovir (ACV), and prednisone. He was started on BIC/TAF/FTC suspension because of deteriorated swallowing. The HIV viral load was increased; however, no drug-resistance genes were detected. We successfully treated him with doltegravir/abacavir/lamibudine suspension. We performed two literature reviews of the administration of BIC/TAF/3TC suspension and VZV vasculopathy in patients with HIV. Three cases of BIC/TAF/3TC suspension were considered treatment failures. Recent history of VZV infection and a CD4 count under 200 μL may be risk factors for VZV vasculopathy. The effective treatment may be using steroid and ACV; however, treatment duration could differ.

Conclusions

BIC/TAF/FTC suspension administration may be unstable, and treating ACV and steroid may be optimal therapy for VZV vasculopathy; however, the evidence level is low.
On the complexity of non-binary tree reconciliation with endosymbiotic gene transfer
Authors: Gascon Mathieu , El-Mabrouk Nadia
Published: July 2023

Reconciling a non-binary gene tree with a binary species tree can be done efficiently in the absence of horizontal gene transfers, but becomes NP-hard in the presence of gene transfers. Here, we focus on the special case of endosymbiotic gene transfers (EGT), i.e. transfers between the mitochondrial and nuclear genome of the same species. More precisely, given a multifurcated (non-binary) gene tree with leaves labeled 0 or 1 depending on whether the corresponding genes belong to the mitochondrial or nuclear genome of the corresponding species, we investigate the problem of inferring a most parsimonious Duplication, Loss and EGT (DLE) Reconciliation of any binary refinement of the tree. We present a general two-steps method: ignoring the 0–1 labeling of leaves, output a binary resolution minimizing the Duplication and Loss (DL) Reconciliation and then, for such resolution, assign a known number of 0s and 1s to the leaves in a way minimizing EGT events. While the first step corresponds to the well studied non-binary DL-Reconciliation problem, the complexity of the label assignment problem corresponding to the second step is unknown. We show that this problem is NP-complete, even when the tree is restricted to a single polytomy, and even if transfers can occur in only one direction. We present a general algorithm solving each polytomy separately, which is shown optimal for a unitary cost of operation, and a polynomial-time algorithm for solving a polytomy in the special case where genes are specific to a single genome (mitochondrial or nuclear) in all but one species. This work represents the first algorithmic study for reconciliation with endosymbiotic gene transfers in the case of a multifurcated gene tree.
CRISPR/Cas12a combined with RPA for detection of T. gondii in mouse whole blood
Authors: Wang Xiaofeng , Cheng Miao , Yang Shuqi , Xing Chen , Li Qian , Zhu Yating , Ji Yongsheng , Du Yinan
Published: July 2023

Background

Toxoplasma gondii is an opportunistic protozoan that is ubiquitous in humans and animals. It can invade any human organ and cause severe diseases, including toxoplasma ophthalmopathy, meningoencephalitis, and liver necrosis. Porcine toxoplasmosis is prevalent in China. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and Cas (CRISPR-Associated Protein) systems are widely used for gene editing and pathogen detection. CRISPR-based diagnostics are molecular assays that have been developed to detect parasites with high sensitivity and specificity.

Methods

This study aimed to establish a combined CRISPR/Cas12a and RPA rapid detection method for T. gondii by targeting the B1 gene and 529 bp repeat element (529 RE). The detection results could be visualized by the fluorescence or lateral flow strips (LFS). The sensitivity and specificity of the method were evaluated, and T. gondii-infected mouse blood was used for detection.

Results

The results indicated that the established method for T. gondii detection was satisfactory, with a detection limit of 1.5 cp/μl for the two loci. Moreover, the B1 gene could detect 1 tachyzoite per reaction, and the 529 RE could detect 0.1 tachyzoite per reaction, consistently with the highly sensitive nested polymerase chain reaction (PCR) results. The method was suitable for strains, including RH, and did not cross-react with other protozoa DNA with similar habits. The T. gondii-infected mouse blood samples were all positive for T. gondii at 1, 3, and 5 days post infection (dpi).

Conclusions

This study established a rapid, sensitive, and time-saving DNA detection method for T. gondii that has the potential to be an alternative tool for T. gondii detection in the field.

Graphical abstract
Unusual presentation of antisynthetase syndrome: a case series and review of the literature
Authors: Estrada-Maya Juan , de los Ángeles Cuellar María , Vargas Lina Patricia , Gómez Carmen Cecilia , Bonilla Andrés , Burgos Pedro Felipe , Bedoya Sergio Alejandro , Oliver María Valentina , Molano Nicolás , Linares Juan Sebastián
Published: July 2023

Background

Antisynthetase syndrome is an inflammatory myopathy that is characterized by the presence of anti-aminoacyl-tRNA synthetase antibodies. Only 30% of those who suffer from the disease can be identified. We present three Hispanic cases of antisynthetase syndrome with unusual clinical pictures were extended myositis panel results enable disease diagnosis and treatment.

Case presentation

A 57-year-old Hispanic/Latino female with an erythematous scaly plaque, unresolved fever and non-immune haemolytic anaemia in whom inpatient work-up for fever of unknown origin was positive for anti-PL12 positive myositis extended panel. A 72-year-old Hispanic/Latino male with amyopathic weakness syndrome and mechanic hands in whom impatient work-up was relevant for proximal muscle uptake and anti-PM75 and AntiPL-12 myositis extended panel. And a 67-year-old Hispanic/Latino male with progressive interstitial lung disease and unresolved fever ended in myositis extended panel positive for antiPL-7. After systemic immunosuppressor treatment, patients had favourable clinical and paraclinical responses during outpatient follow-up.

Conclusions

The high variability of the antisynthetase syndrome in these cases demonstrates the importance of identification through an expanded panel and highlights the probability that this is a variable disease and that we need to include emerging molecular tests to promote the timely treatment of patients.
Formation mechanism of copper-gilded coronet ornaments excavated from a Sui or early Tang tomb situated in Xi’an, Shaanxi
Authors: Shao Yanbing , Jiang Fengrui , Yang Junchang , Zhang Quanmin , Lu Xuan , Fu Wenbin , Yu Sumei
Published: July 2023

The formation of the gold layer in mercury gilding occurs through the heating a gold amalgam. As a result, the formation mechanism and technical characteristics of gilded products are closely related to the temperature at which they are heated. In this study, XRD and XPS analysis of a copper-gilded coronet from the Sui or Tang dynasties revealed that Au3Cu was one of the main phases of the gold layer. Therefore, base on the thermodynamic stability of ordered phases like Au3Cu, the estimated heating temperature for this copper-gilded coronet ranged from 240 to 285 ℃. Furthermore, SEM–EDS analysis of the cross-sectional concentration distribution of Cu indicated that the diffusion distance of Cu during heating did not exceed 2 μm. At 240–285 ℃, Cu diffused along the defects of the gold layer, and the diffusion process followed Fick’s second law. Previous research has indicated that the defect path diffusion coefficient of Cu is on the order of 10–12 cm2/s, and the heating time of the gilding process is typically considered to be 15 min. Using the diffusion equation, the calculated diffusion distance of Cu aligned with the diffusion behavior of Cu at 240–285 ℃, confirming the inferred heating temperature range. Additionally, at these temperatures, the gold layer was formed through the solid-state reaction of the gold amalgam and was bonded to the substrate through the diffusion of Cu.
Does ownership structure reduce earnings manipulation practice of Egyptian listed firms? Evidence from a dynamic panel threshold model
Authors: Attia Eman F. , Khémiri Wafa , Mehafdi Messaoud
Published: July 2023

This paper analyzes the nonlinear relationship between corporate ownership structure and income manipulation through accrual-based earnings management in the Egyptian context. To do so, we develop a sample of 78 listed non-financial firms, covering the period 2008–2017. Using the dynamic panel threshold analysis approach (Seo and Shin in J Econom 195: 169–186, 2016), we found a nonlinear relationship between ownership structure and earnings manipulations. This proves the presence of an optimal ownership structure threshold below which the ownership structure generates an entrenchment effect on earnings management. However, above this threshold, the ownership structure has an alignment effect. Certainly, these results confirm the theoretical predictions in relation to managerial ownership, governmental ownership, and earnings management (agency, political and development theories, respectively). These results yield important policy implications. It is recommended to set an optimal threshold of ownership structure to control the firm`s managers. This is likely to avoid earnings management.
Characterization, cellular uptake in Caco-2 cells and physiologically based pharmacokinetic modeling of baicalin-loaded solid lipid nanoparticles
Authors: Ammar Hussein O. , Shamma Rehab N. , Yousry Carol , Elbatanony Rasha S. , Khater Basma , Ghoneim Amira M.
Published: July 2023

Background

Baicalin is a natural compound having intriguing and useful pharmacological properties that may be used alone or in conjunction with other treatments in a variety of therapeutic areas. However, the drug has low aqueous solubility and poor absorption. The aim of this research was to optimize the bioavailability of baicalin through incorporation into solid lipid nanoparticles.

Results

The particle size of the prepared baicalin-loaded solid lipid nanoparticles ranged between 248.2 ± 1.72 nm and 291.9 ± 30.9 nm. The speed, duration of homogenization and the content of both the surfactant and soy lecithin affected the particle size and the entrapment efficiency. The optimized formula showed superiority in drug release over the drug suspension, with biphasic release profile. Cell culture results showed good accumulation of the drug into the Caco-2 cells that increases over time in the case of the optimized formula. Physiologically based pharmacokinetic (PBPK) modeling simulated enhanced bioavailability of the optimized formula, compared to the drug suspension.

Conclusion

Solid lipid nanoparticles have demonstrated potential as cancer therapy nanocarriers. Reduced toxicity, improved drug absorption and flexibility in combining hydrophilic and lipophilic medications are all significant advantages of this system. The PBPK simulation suggested the safety of the optimized BA-SLNs in cancer patients and in geriatric populations.
Child marriage and its association with partner controlling behaviour against adolescent girls and young women in sub-Saharan Africa
Authors: Ahinkorah Bright Opoku , Aboagye Richard Gyan , Okyere Joshua , Seidu Abdul-Aziz , Budu Eugene , Yaya Sanni
Published: July 2023

Background

Child marriage and partner controlling behaviours are culturally seated phenomena in sub-Saharan Africa (SSA). Child marriage refers to any legal or customary union involving a boy or girl below the age of 18. Partner controlling behaviour on the other hand refers to a situation where a sexual partner consistently tries to control their spouse’s behaviours, movements, and social contacts with other people. This study examined the association between child marriage and partner controlling behaviour among adolescent girls and young women (AGYW) in SSA.

Methods

We extracted data from the most recent Demographic and Health Surveys of 26 countries in SSA. Countries whose surveys were conducted from 2010 to 2020 were included in the study. A total of 26,970 AGYW (15–24 years) were included in the study. We used a multilevel mixed-effect binary logistic regression analysis to examine the association between child marriage and partner controlling behaviour.

Results

The average prevalence of child marriage was 55.40% (95% CI: 48.83–61.97). This proportion ranged from 19.62% (95% CI: 16.71–22.53) in South Africa to 85.10% (95% CI: 83.14–87.06) in Chad. The proportion of AGYW who had experienced partner controlling behaviour was 68.36% (95% CI: 64.40–72.33), and this ranged from 38.40% (95% CI: 35.55–41.25) in Burundi to 88.18% (95% CI: 83.80–92.56) in Gabon. AGYW who married as child brides were more likely [aOR = 1.31; 95% CI = 1.21, 1.43] to experience partner controlling behaviour compared to those who did not marry as child brides. AGYW in Western [aOR = 1.51; 95% CI = 1.33, 1.71] and Eastern [aOR = 1.31; 95% CI = 1.13, 1.50] part of SSA were more likely to experience partner controlling behaviour compared to those in Central Africa.

Conclusions

Our study has shown that there is a significant association between child marriage and the likelihood of experiencing partner controlling behaviour in SSA. Effective policies and interventions are, therefore, needed to prevent child marriage and raise AGYW’s awareness of its implication on victims of partner controlling behaviours.
Meet the editorial board members: Stephanie Lo and Robert Paulino-Ramírez
Authors: Lo Stephanie , Paulino-Ramírez Robert
Published: July 2023

In this Q&A, Stephanie Lo and Robert Paulino-Ramírez answer questions about their research fields and share insights into their role as editorial board members at the journal.
A Bone Fracture Detection using AI-Based Techniques
Authors: Pareek Preksha , Jayaswal Ruchi , Patil Shruti , Vyas Kishan
Published: July 2023

The medical field in itself is a complex term where the diagnosis is of the most importance. If there is a correct diagnosis made on time in the appropriate time duration then the treatment can be started in a timely manner and this treatment will be beneficial in curing the patient. There are many different techniques that are available to find the abnormalities in an image given but we will review some of them which are most recently developed and will compare the results of each of them. A detailed study is done at the end of this paper which gives insights into fractures and their types. The dataset which we would consider is the MURA dataset. Discussion about further research in this area is also done to help researchers in exploring new dimensions in this field.
Information Monitoring of Transmission Lines Based on Internet of Things Technology
Authors: Du Wei , Wang Jiaying , Yang Guozhu , Zheng Sijia , Zhao Yajie
Published: July 2023

To solve the problem of difficult real-time monitoring of current transmission lines, this article proposes an information-based monitoring system for transmission lines based on Internet of Things technology. The system utilizes the characteristics of strong scalability, good fault tolerance, low power consumption, and low cost of the Internet of Things. Taking the ultra-low power consumption MSP430 microcontroller and CC2430 radio frequency module as the core, a line monitoring system based on the Internet of Things is designed. The proposed design uses ZigBee wireless sensor network technology which is powered by solar energy. The collection, transmission, processing and judgment of various environmental parameters of the line are realized. The data information is transferred to the monitoring center of the upper computer through GPRS. When there is an abnormality, it can send a mobile phone short message to the person in charge to feedback the abnormal content in time. The distribution network's load symmetry allowed for the development of several locating procedures. For the three-phase symmetric scheme, the fault location approach based on line supply characteristics was employed, and for the three-phase asymmetric scheme, the fault location technique based on line impedance is proposed. One of the most vital uses for the Internet of Things is in the mitigation of power transmission line failures and disasters. Improved power transmission dependability, less financial loss, and fewer power outages are all possible thanks to the Internet of Things' cutting-edge sensing and communication technology. This research introduced the use of IoT in online monitoring system of electricity transmission line with a focus on the characteristics of the construction and development of smart grid. The results indicated that the system's highest temperature difference is 0.31 C, while the maximum humidity difference is 1.38%. The system increases the safety and manageability of electricity transmission while also fostering the widespread adoption and technical integration of the smart grid and the Internet of Things.
Research Highlight Generation with ELMo Contextual Embeddings
Authors: Rehman Tohida , Sanyal Debarshi Kumar , Chattopadhyay Samiran
Published: July 2023

With the advent of digital publishing and online databases, the volume of textual data generated by scientific research has increased exponentially. This makes it increasingly difficult for academics to keep up with new breakthroughs and synthesise important information for their own work. Abstracts have long been a standard feature of scientific papers, providing a concise summary of the paper's content and main findings. In recent years, some journals have begun to provide research highlights as an additional summary of the paper. The aim of this article is to create research highlights automatically by using various sections of a research paper as input. We employ a pointer-generator network with a coverage mechanism and pretrained ELMo contextual embeddings to generate the highlights. Our experiments shows that the proposed model outperforms several competitive models in the literature in terms of ROUGE, METEOR, BERTScore, and MoverScore metrics.
Accident Attention System for Somnambulism Patients
Authors: Ziyad Shabana R , Altulyan May , Liakathunisa  , AlHarbi Meshal
Published: July 2023

Promising technologies such as sensors, networking, and edge have led to many smart healthcare solutions to monitor and track patient health status. The health sector is now experiencing a significant transformation from conventional patient care to a smart healthcare environment. Smart health care allows medical professionals to monitor patients remotely and visualize the disease prognosis effectively. The Internet of medical things connect patients, doctors, and medical equipment via wireless networking technologies to process the data with Artificial Intelligence models. One of the domains of automated health care systems is to alert the caregivers and hospital on emergency conditions. This research study is a novel work that aims to help the caregivers of somnambulism patients attend to them in case of emergency. Sleep quality improves the health and work efficiency of any person. The caregivers of sleepwalking patients suffer from lack of sleep as the patient gets active during the night hours. The model is based on fall detection and sleep detection from wearable sensor data. The fall detection model includes feature selection by LASSO and classification by ensemble classifier. The proposed methodology shows improved performance for the fall detection model for all ensemble machine learning classifiers.
Persistent cardioactive glycosides intoxication related to gastric phytobezoar of oleander leaves
Authors: Pescia Michel , Conti Marco , Contratto Romina
Published: July 2023

Nerium oleander is a plant containing cardiac glycosides, and intoxication with its leaves is a medical emergency. We report the case of a 73-year-old man who took a decoction of oleander leaves for a reckless purpose. Upon arrival in the emergency room, he presented an altered state of consciousness, drooling and vomiting. He was bradycardic with intermittent third- degree atrioventricular block and typical downsloping ST-segment depression related to glycosides toxicity. Despite initial treatment with atropine, isoprenaline and repeated bolus of digoxin-specific antibody (Fab) fragments, symptoms were persistent 12 hours after admission. Suspecting that the patient not only drank the decoction but also ingested the leaves and had slow gastric emptying, we performed gastric lavage without benefit. We subsequently performed a gastroscopy that showed an oleander phytobezoar, and its removal permitted a rapid clinical improvement. Treatment with digoxin-specific antibodies for intoxication is well described and dosage should be adapted to the plasmatic level. Such an examination is useless in oleander intoxication because it does not represent the real quantity of toxin. The dosage of antibodies is empiric and should be guided by the clinical severity. In such intoxication, the presence of a phytobezoar from oleander leaves cannot be excluded so we believe that a gastroscopy for its mechanical removal should always be considered to avoid persistent release of toxin.
Caseous calcification of the mitral annulus: mimicking a cardiac mass.
Authors: Bitar Zouheir , Maadarani Ossama Sajeh , Rajendran Harikrishna , Al Hamdan Rashed Juma , Elhabibi Mohamed
Published: July 2023

Mitral annulus calcification is a common incidental finding in echocardiography examination of predisposed populations. On the other hand, caseous calcification of the mitral annulus is a rare variant that challenges the physician to differentiate it from different causes of cardiac masses. We describe a case of incidentally discovered caseous calcification confirmed with CT cardiac and cardiac magnetic resonance.
Study of biodeterioration and evaluation of proteolytic activity caused by microorganisms in specimens of a zoological collection in Colombia
Authors: Carrillo Chavez Lisa Maria , Arias Bermúdez Nicolás , Nieto Venegas María José , Pinto Sanchez Nelsy Rocío , Patiño María Camila
Published: July 2023

Zoological collections shelter specimens that represent the history of biodiversity at a particular time and place. Their deterioration over time results in the loss of information, therefore, it is crucial to evaluate the state of preservation of the collections to take measures regarding their management. In this study, the state of conservation of the specimens deposited in the zoology collection was diagnosed, taking into account the presence of indicators of deterioration and biodeterioration. In addition, fungi and bacteria were isolated and the proteolytic activity of some dominant strains of fungi was evaluated. It was found that 42% of the 146 specimens analyzed showed signs of biodeterioration associated with microorganisms commonly reported in the environment, such as Penicillium sp. and Cladosporium sp., which presented proteolysis in feather and hair substrates. This suggests an association between environmental conditions and the manner of storage with the deterioration of the specimens.
Exploring Andalusian industrial heritage through data science: breaking down the gaps and concerns to visualise opportunities
Authors: Ferreira Lopes Patricia
Published: July 2023

Industrial heritage, understood as the group of elements related to the work culture and production activities that emerged during the industrial revolution, has been surveyed and documented extensively in Spain in recent decades. This is particularly the case of recent years thanks to the advent of digital tools and systems. In the case of Andalusia, the efforts to document, disseminate and protect industrial heritage have been the subject of a variety of actions and projects. This paper describes the methodology used and the results obtained from a review of the existing 1,443 records of immovable assets of industrial heritage. The results point to deficiencies in the updating and incorporation of information in the Digital Guide, and to the need to carry out actions geared more towards understanding the elements as an integral whole made up of the landscape in which they appear.
An in-depth look at the application of GIS for industrial heritage documentation
Authors: Ferreira Lopes Patricia , Moya Muñoz Jorge , Pires Rosa Manuela
Published: July 2023

The use of geospatial technologies to identify and document architectural heritage, with the associated benefits for managing information, is already relatively widespread. However, there has been little discussion about the difficulties, decision-making process and problems encountered when using GIS to digitize data, identify and document this heritage. This study sets out to propose a conceptual work to explore the relationship between immovable industrial heritage documentation and GIS application on the basis of case studies, in particular: the identification and documentation of the industrial heritage in the Eurocity of Guadiana and the olive mills in Écija. After discussing the workflow developed, the difficulties and problems encountered, and how these determine the structure of the GIS model, the decision-making process and the results, this paper concludes that further progress is still necessary to acquire a more pragmatic vision of the use of GIS in the field of industrial archaeology.
How Lipman’s “caring thinking” theory for human thought may encourage the safeguarding of industrial and technological heritage
Authors:   Greek Ministry of Culture, MΕΛΜΟΦΑΚΕ Μuseum, Greece, Konstandinos Stoupathis
Published: July 2023

This paper describes the potential for “caring thinking” of Matthew Lipman’s philosophy to be applied from education to museological practice to enhance new decision-making models for conservation. “Caring thinking” is crucial when applied from education to heritage conservation, as it does not only concern the treatment of the deteriorated parts of any industrial object but the truth, the museological content that lies beyond the aesthetic or historical values that have to be thoroughly examined. The Lipman theory articulates complex modes of thought that include: a) valuational, b) affective, c) active, d) normative and e) the empathy of man for human ingenuity, effort and expectations. This effort, reflects the need for the industrial and technological heritage conservator not only to extend the life-span of the collections but to strive to retain their intangible value and enhance the viewer’s museological engagement with them.
A tale of hazards: Ingenium’s industrial collections move
Authors: Marshall Skye , Riddle Jacqueline
Published: July 2023

In 2018, Ingenium began a large-scale collections move, consolidating artefacts from four rental warehouses into a new purpose built storage facility. Collection hazards were assessed, prioritised and treated according to Ingenium’s comprehensive Collection Risk Management Program (CRMP), placing health and safety at the forefront of collections care. This paper will present hazard assessment and mitigation in one warehouse, the Building 2421 Reserve Collection, showing the challenges overcome to move a large industrial collection on a tight schedule and with limited staffing and resources. A selection of case studies will provide examples of hazard mitigation in artefacts containing asbestos, radioactivity, polychlorinated biphenyls (PCBs) and mercury. The case studies demonstrate how simple solutions and triage treatments were implemented by conservators and specialised contractors in order to mitigate collection hazards during the move project. The Building 2421 Reserve Collection move was completed in December 2021 and the full collections move was completed in August 2022.
Investigating five totalizing counters manufactured by the Alphonse Darras company of the CNAM collections in Paris
Authors: Schröter Julie , Foasso Cyrille , Bellot-Gurlet Ludovic , Brambilla Laura
Published: July 2023

The paper reports the study of five totalizing counters preserved in the collections of the CNAM (museum of the French National Conservatory of Arts and Crafts) in Paris. These artefacts are part of a corpus of over forty counters attributed to the Darras company founded by engineer Alphonse Darras (1860-1936). In the framework of the LacCA project at Haute Ecole Arc, Neuchâtel (Switzerland), dedicated to the characterization of lacquered copper-alloys, our attention was drawn to the different aspects of the object’s coatings. Lacquers were frequently applied to technical objects to both protect them from corrosion and provide an esthetical appearance. Five totalizing counters showing various typologies and surface colours were chosen from the set and explored by a non-invasive multi analytical approach. The comparative study – investigating lacquering processes and materials - contributes to the historical study of these artefacts.
Return of the space hoppers: more measures on dH Comet G-BDIX
Authors:   National Museum of Flight, East Fortune Airfield, Haddington, East Lothian EH39 5LF, United Kingdom, Buergel Thilo
Published: July 2023

De Havilland Comet 4C “G-BDIX” arrived at the National Museum of Flight (NMoF) in Scotland in September 1981 and has been displayed outdoors and fully exposed to the environmental conditions ever since. In 2018, National Museums Scotland (NMS) set a development in motion at its NMoF site with the aim to display the dH Comet, amongst other aircraft, in a new, environmentally controlled hangar. Due to planning permission issues the project was cancelled, and the museum is now scoping out alternative options. This led to focus on the outside of the aircraft and provided the opportunity to revisit the work carried out during a project in 2012/13, at the time making the passenger cabin watertight and rectify interior damage.
Assessment of flood mitigation strategy based on integrated approach of remote sensing and coastal vulnerability geospatial modeling at the coastal plain of Suriname
Authors: Martoredjo Irvin , Helmi Muhammad , Maryono Maryono
Published: July 2023

Suriname is the smallest South American nation with a low-lying coastal plain that is vulnerable to inundation from the Atlantic Ocean and inland rivers, as well as pluvial flooding primarily due to rainfall. Paramaribo, the capital of Suriname, has the highest population density, and its demographics extend into the surrounding districts of Wanica and Commewijne. Suriname has experienced flood disasters almost annually, which has exacerbated in recent years, posing a significant socioeconomic challenge. The country must balance the need for flood disaster adaptation and climate resilience with the potential impact on its resources and well-being of settlement areas. Policymakers and other stakeholders are working to address environmental impacts on the coast, but there is still a need for a comprehensive approach to monitor and manage flood impacts. This research has three objectives. The first is to analyze flood frequency events from 2021 to 2023 using multi-temporal satellite image processing from Sentinel-1 SAR (Synthetic Aperture Radar). The second is to generate a Coastal Flood Vulnerability Index (CFVI) for floods using a geospatial multi-criteria analysis approach based on exposure, sensitivity, and adaptive capacity components. The third objective is to assess the mitigation strategy for floods in settlement areas based on an integrated analysis of CFVI and stakeholder perception. The research methodology uses a multi-criteria analysis regarding settlement areas and ranking each component by expert opinion in an equation derived from Intergovernmental Panel on Climate Change (IPCC) assessment report at district level. The CFVI indices rely on secondary data acquisition from national and global datasets or referenced works. Interviews were conducted to better understand the stakeholder’s perspectives that are at a strategic or governing level, and to evaluate the existence of flood early-warning and other adaptation capabilities. A flood mitigation strategy is then suggested for the most vulnerable district by CFVI score.
Over-expression of Apolipoprotein J Inhibits Cholesterol Crystal-Induced Inflammatory Responses via Suppressing NLRP3 Inflammasome Activation in THP-1 Macrophages
Authors: Li Y. , Song Y.-Q. , Zhang Y. , Liu T. , Qin Qin
Published: July 2023

Apolipoprotein J (clusterin) is a component of high-density lipoproteins, the high level of which is reversely correlated with the risk of coronary heart disease. In addition, it exerts anti-inflammatory and anti-apoptotic effects on endothelial cells and inhibits smooth muscle cell migration and proliferation, indicating that it may play a protective role in cardiovascular disease. However, the exact mechanisms by which this occurs remain unclear. This study aimed to clarify these underlying protective mechanisms by researching the inhibitory effects of apolipoprotein J via the NOD-like receptor protein 3 pathway on the inflammation induced by cholesterol crystals in THP‑1 macrophages. In culture, THP-1 macrophages were infected with adenoviral vectors containing apolipoprotein J genes and subsequently treated with cholesterol crystals. The inflammatory cytokines interleukin‑1β, interleukin 18 and tumour necrosis factor α were quantitatively measured with ELISA kits. NOD-like receptor protein 3, cysteinyl aspartate specific proteinase 1 and interleukin 1β were evaluated by Western blot and PCR analysis. As a result, apolipoprotein J expression was found to remarkably decrease the levels of inflammatory cytokines, including tumour necrosis factor α, interleukin 18 and interleukin 1β, secreted by THP‑1 macrophages. It was also found capable of inhibiting the levels of NOD-like receptor protein 3, cysteinyl aspartate-specific proteinase 1 and interleukin 1β both at the protein and mRNA levels. In the current study, we revealed that over-expression of apolipoprotein J attenuated the inflammation induced by cholesterol crystals through inhibition of the NOD-like receptor protein 3 inflammasome pathway.
JAB1 Promotes High Glucose-Induced Inflammation and Extracellular Matrix Deposition in Glomerular Mesangial Cells by Regulating Angiopoietin-Like Protein 2
Authors: Zhu P. , Wu Yihua , Gu Y. , Li C.
Published: July 2023

Diabetic or hyperglycaemic conditions stimulate the inflammatory response, excessive accumulation of extracellular matrix, and result in glomerulosclerosis, a scarring process of diabetic nephropathy. c-Jun activation domain-binding protein 1 (JAB1) functions as a regulator of pathways involved in cellular apoptosis and proliferation. The role of JAB1 in diabetic nephropathy was investigated in this study. Firstly, glomerular mesangial cells (GMCs) were treated with high glucose, and high glucose conditions induced up-regulation of JAB1 in the GMCs. Moreover, IL-6, TNF-α, MCP-1, and IL-1β were also elevated in high glucose-induced GMCs. Secondly, silencing of JAB1 reduced the levels of IL-6, TNF-α, MCP-1, and IL-1β in high glucose-induced GMCs. In addition, silencing of JAB1 attenuated the high glucose-induced decrease of superoxide dismutase (SOD) and the increase of reactive oxygen species (ROS) and malondialdehyde (MDA). The increased TGF-β1, collagen I, collagen IV, and fibronectin levels in high glucose-induced GMCs were restored by knockdown of JAB1. Thirdly, angiopoietin-like protein 2 (ANGPTL2) expression was reduced by JAB1. Over-expression of ANGPTL2 weakened the JAB1 silence-induced decrease of IL-6, TNF-α, MCP-1, IL-1β, TGF-β1, collagen I, collagen IV, and fibronectin. In conclusion, silencing of JAB1 reduced extracellular matrix deposition and suppressed inflammation in high glucose-induced GMCs through down-regulation of ANGPTL2.
Barbaren, Asiaten, Sklaven, Juden. Rassismus in der Antike?
Authors: Meyer-Zwiffelhoffer Eckhard
Published: July 2023

Der Aufsatz geht der Frage nach, ob es in der griechischen und römischen Antike Vorstellungen, Handlungsweisen oder gesellschaftliche und politische Strukturen gegeben hat, die als „rassistisch“ zu bezeichnen wären. Das Problem einer solchen Untersuchung besteht darin, dass in der Forschung keine Einigkeit darüber herrscht, was unter „Rassismus“ zu verstehen sei: Dominierten bis in die späten 1960er Jahren Konzeptionen, die auf einem biologischen Rassenbegriff beruhten, so wurden seither zahlreiche Theorien formuliert, die von einem kulturalistischen Verständnis des Phänomens im Sinne eines „Rassismus ohne Rassen“ ausgehen und tendenziell jegliche soziale und politische Diskriminierung – etwa aufgrund von Herkunft, Religion, Klasse, Geschlecht, Hautfarbe – als „rassistisch“ begreifen. Im ersten Teil des Aufsatzes zeichne ich die Geschichte des Rassismusbegriffs nach und entwickele eine eigene Konzeption, deren Kriterien es erlauben, kultur- und epochenübergreifend festzustellen, welche Verhältnisse wir zu Recht rassistisch nennen können, ohne zugleich jede Form von Diskriminierung als solche zu bezeichnen. Im zweiten Teil des Aufsatzes untersuche ich dann vier antike Phänomene, die in der modernen Forschung unter Rassismusverdacht stehen, unter dem Aspekt, ob hier sinnvollerweise von „Rassismus“ zu sprechen wäre: die griechische und römische Barbarenkonzeption, die sogenannte hippokratische Umwelttheorie, Aristoteles’ Theorem des „Sklaven von Natur“ und die antike Judenfeindschaft.
Vormoderne Recycling-Mentalität? Abfall und Abfallregime im frühneuzeitlichen London
Authors: Neumann Franziska
Published: July 2023

Recycling, verstanden als Weiter- und Wiederverwertung von Abfallstoffen, spielte in der Frühen Neuzeit ohne Zweifel eine wichtige Rolle: Aus Asche wurden Ziegelsteine, aus Fäkalien Zusatzstoffe für Düngermittel, zerbrochenes Geschirr und Bauschutt hingegen fanden als Füllmaterial eine neue Bestimmung. Zugleich reicht eine ausschließliche Fokussierung auf Recycling nicht aus, um der Komplexität von Abfall gerecht zu werden. Jede Epoche bildet ihre eigenen Abfallstoffe aus, die eng mit Produktions-, Lebens- und Konsumgewohnheiten, aber auch mit Werten, Normen und Ordnungsvorstellungen verwoben sind. Der Umgang mit Abfall in der frühneuzeitlichen Stadt wurde, so die These des vorliegenden Beitrags, von einem deutlich breiteren und komplexeren Spektrum an bisweilen konfligierenden Wahrnehmungen und Handlungsweisen geleitet, als die Scharfeinstellung auf Recycling vermuten lässt. Am Beispiel von Haushaltsabfällen in London im 18. Jahrhundert plädiert der Beitrag dafür, Recyclingpraktiken in eine breiter angelegte Geschichte von „Abfallregimen“ zu integrieren und nach dominanten kulturellen Mustern im Umgang mit Abfall zu fragen. Aufgrund der Vielzahl an Aspekten, die Abfallregime prägen, können diese zugleich als Sonde dienen, um Einblicke in die Dynamiken urbanen Zusammenlebens in der Frühen Neuzeit zu gewinnen. Damit bietet eine Fokussierung auf Abfall die Chance, neue Perspektiven auf eine Kulturgeschichte der Stadt zu werfen.
Intelligence Games: A Useful Tool in Philosophy and Logic Education
Authors: Zhou Longjun
Published: July 2023

Intelligence games are mainly comprised of intellectual activities and often based on certain intellectual training purposes. They are designed for individuals to increase knowledge and develop thinking skills in a voluntary and relaxed mood through vivid, novel, and engaging activities (Huang, 1985). Intelligence games require thinking skills such as reasoning, logical thinking, imagination, strategical judgement, creative thinking, etc., thus having the potential for positively affecting student cognitive development. They can be organized by adults or initiated by students themselves. The content of intelligence games covers a wide range of domains such as computer, mathematics, literature, and more.
Enriching Students’ Academic Life with Creative Education
Authors: Yang Yaodong
Published: July 2023

As research and practical exploration in education intensify, the awareness that school education should aim at outcomes more than just student academic achievements has been heightening in the educational community. Social advancement raises more demanding requirements for education, posing increased responsibilities on schools and instructors. There is a growing consensus that schools should provide students with a more colorful academic life, which goes beyond curricula content and allows students rich academic experiences, in order to foster all-round development in them.