bluuebunny/crossref_metadata_2025 huggingface dataset:
Memorias de sostenibilidad como impulsores de la responsabilidad social en empresas de salud
Authors: Buitrago Mejía Aracelly , Rodríguez Barrero Mario Samuel , Izquierdo Hernández Patricia
Published: May 2024

Las memorias de sostenibilidad son informes públicos sobre los impactos económicos, ambientales y sociales de lasorganizaciones en el logro de los ODS y sus acciones de responsabilidad social. Este conocimiento es importante paraidentificar las acciones que el sector salud está desarrollando para el cumplimiento de estos objetivos, ademáspermitirá diseñar estrategias que permitan desarrollar procesos de responsabilidad social cuyo fin sea fortalecer a lasorganizaciones y avanzar en el cumplimiento de sus compromisos en esta materia. El objetivo es identificar lapercepción de las empresas del sector salud sobre la importancia, pertinencia, impacto e implementación deestrategias para contribuir al logro de los ODS. El alcance del estudio es descriptivo, su enfoque cuantitativo y su cortetransversal. La investigación aborda el concepto de sustentabilidad desde la perspectiva de los empresarios a travésde la aplicación de un instrumento estructurado con 4 variables: Percepción de la pertinencia y factibilidad deimplementar memorias de sustentabilidad, Percepción del impacto generado por la empresa, Percepción y gestión delimpacto ambiental y Percepción e incidencia de los indicadores. Para recolectar la información en fuente primaria seutilizó como técnica, una entrevista semiestructurada de 21 preguntas la cual fue validada con el Alfa de Cronbach de0.758, la muestra se define con un grado de confianza del 95% para un total de 281 empresas. Los resultados muestranque el 45% de los emprendedores considera que sus actividades generan un impacto positivo en las dimensiones deldesarrollo sostenible, el 64% se preocupa por su contribución al logro de los ODS y el 30% considera que estascontribuciones deberían ser obligatorias y reveladas a la sociedad, por lo que se recomienda avanzar hacia laconsolidación de las memorias de sostenibilidad como dinamizadoras de la responsabilidad social.
INFLUENCIA DE LOS ÁCIDOS GRASOS DE ACEITES ANIMALES DE CERDO Y POLLO EN LA PRODUCCIÓN DE BIODIÉSEL
Authors: Vera Rozo James Ronald , Riesco Ávila José Manuel , Ramón Valencia Jairo Lenin
Published: May 2024

Los ácidos grasos provienen de múltiples aceites animales y vegetales, donde este es el principal reactivo para la producción de biodiésel y representa cerca del 80% de su costo comercial. Adicional se requiere de un alcohol de cadena corta como etanol y metanol, también de catalizadores para producir la reacción de transesterificación por la cual se obtienen ésteres (biodiésel). Los ácidos grasos varían dependiendo de su origen, comúnmente en cadenas de doce a veinte carbonos y en su mayor proporción se encuentran el ácido palmítico (C16) y los ácidos oleicos (C18). Existe una mayor afinidad de algunos ácidos grasos con el alcohol en reacción, la cual depende de múltiples parámetros como agitación, calentamiento y contacto entre estas dos sustancias inmiscibles en reacción. Este trabajo presenta la producción, caracterización y afinidad del biodiésel producido de dos materias primas de origen animal bajo una relación molar metanol:aceite de 6:1 e hidróxido de potasio (KOH) como catalizador al 1.5 %. La caracterización del biodiésel se desarrolla de acuerdo con la UNE-EN 14214 determinando el FAME (Fatty Acid Methyl Esters) por cromatografía de gases, densidad, viscosidad y poder calorífico de cada una de las materias primas seleccionadas.
Evaluación financiera de la tecnología en la producción lechera: mejoras en la rentabilidad y la gestión administrativa agropecuaria
Authors: Escalante Juan Carlos , Cardona Montoya Juan Camilo , Vélez Tamayo Julián Mauricio
Published: May 2024

Para esta investigación se estableció como objetivo evaluar financieramente la tecnología en la producción lechera: mejoras en la rentabilidad y la gestión administrativa agropecuaria. Respecto al estudio, el mismo es de carácter descriptivo, con estadísticas de frecuencias absolutas y relativas, realizado a través de un muestreo opinático de manera intencional de treinta (30) unidades de producción (U.P.), representativo del universo de estudio conformando por 154 fincas. Se encuestaron con el propósito de obtener los datos necesarios de estos sistemas de producción los cuales indican los siguientes: primero, se clasificaron las unidades por bloques de acuerdo con la superficie a fin de poder evaluar su productividad con relación a los indicadores productivos, como productividad por superficie, productividad por unidad animal (U.A) y productividad por mano de obra. De todas las fincas sujetas a estudio veinte y nueve (29) fueron ubicadas en el nivel de medias tecnologías según sus indicadores productivos; la productividad por superficie es de 3,23 litros (L.) por hectárea (has); la productividad por unidad animal (U.A.) es 5,94 L. /U.A. y de la mano de obra 134,2 L. por hora restando una (1) U.P. que presento una productividad de 2,2L/has para superficie, 2.5 L.  U.A. y para la mano de obra 50 L./H. cabe destacar que estas productividades fueron comparadas; de estas comparaciones se encontraron diferencias en cuanto a los indicadores de productividad en términos porcentuales el 96,70% de las unidades fueron del nivel de tecnologías media ya  que cuentan con los requerimientos tecnológicos; por lo que se recomendó a los productores establecer programas de consolidación que tomen en cuenta a la tecnología basada en los rendimientos productivos que se demostraron a través de los indicadores productivos antes mencionados y la relación existente entre la tecnología y la productividad.
Introducción al Dosier: Genocidio indígena y mercado de trabajo
Authors: Pérez Pilar
Published: May 2024

Introducción al Dosier: Genocidio indígena y mercado de trabajo
Juventudes rurales intersticiales. Aportes para un enfoque etario en la ruralidad argentina
Authors: Barés Aymará , Roa María Luz , Hirsch Mercedes
Published: May 2024

En este artículo nos preguntamos qué es lo que define a las experiencias juveniles en la ruralidad argentina. Para ello, presentamos una revisión crítica sobre la problematización de “la juventud rural” en las ciencias sociales y humanas, puntualizando en la producción latinoamericana, especialmente en Argentina. Primeramente, revisamos enfoques teórico-metodológicos y lineamientos ligados a ámbitos de investigación y experiencias de educación, gestión, trabajo social, militancias y políticas públicas con jóvenes en la ruralidad. En segundo lugar, focalizamos en la conformación de un campo de estudio sobre las juventudes rurales en Argentina a partir de la década del 2000 con aportes teórico-metodológicos de investigaciones recientes sobre educación, subjetividades e identidades étnico-juveniles. Con estos aportes, finalmente avanzamos en la propuesta de un enfoque etario de la ruralidad. Como conclusión, proponemos hablar de “juventudes intersticiales”, diferenciando dimensiones socioculturales, generacionales, experienciales, clivajes y perspectivas interseccionales en los mundos rurales.
Permainan Tradisional Jamuran dalam Membentuk Karakter Profil Pelajar Pancasila di Sekolah Dasar
Authors: Rizkiana Yunestria , Rifiyati Dian
Published: May 2024

Pembentukan karakter yang sesuai dengan identitas bangsa merupakan hal penting, terutama di tingkat Sekolah Dasar. Karakter yang diharapkan telah dijelaskan dalam profil pelajar Pancasila yang terdapat dalam kurikulum merdeka. Permainan tradisional Jamuran, sebagai bagian dari warisan budaya yang edukatif, memiliki potensi untuk mengungkap nilai-nilai karakter yang terkandung di dalamnya. Tujuan dari penelitian ini adalah untuk menjelaskan hasil analisis karakter profil pelajar Pancasila yang terdapat dalam permainan tradisional Jamuran di Sekolah Dasar. Pendekatan yang digunakan adalah studi pustaka kualitatif dengan teknik analisis deskriptif. Hasil analisis mendalam menunjukkan bahwa permainan tradisional Jamuran mencerminkan enam karakter yang ada dalam profil pelajar Pancasila, yaitu keimanan dan ketakwaan kepada Tuhan Yang Maha Esa melalui kepedulian terhadap lingkungan dan penghargaan terhadap keberagaman ciptaan Tuhan, kemandirian melalui kemampuan menentukan nama jamur sendiri, kerja sama melalui kekompakan dan kebersamaan dalam bermain, keberagaman global melalui upaya melestarikan kearifan lokal, berpikir kritis melalui pemikiran yang sulit dalam menentukan nama jamur, dan kreativitas melalui kebebasan berimajinasi dalam memberi nama jamur yang unik.
Polymeric Nanoparticles (PNPs) as drug delivery systems for SARS-CoV-2
Authors: Adu Elizabeth , Patel Siddharth A. , Catino Arthur J. , Medhi Riddhiman
Published: May 2024

Researchers from all over the world have been working tirelessly to combat the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 pandemic since the World Health Organization (WHO) proclaimed it to be a pandemic in 2019. Expanding testing capacities, creating efficient medications, and creating safe and efficient COVID-19 (SARS CoV-2) vaccinations that provide the human body with long-lasting protection are a few tactics that need to be investigated. In clinical studies, drug delivery techniques, including nanoparticles, have been used since the early 1990s. Since then, as technology has advanced and the need for improved medication delivery has increased, the field of nanomedicine has recently seen significant development. PNPs, or polymeric nanoparticles, are solid particles or particulate dispersions that range in size from 10 to 1000 nm, and their ability to efficiently deliver therapeutics to specific targets makes them ideal drug carriers. This review article discusses the many polymeric nanoparticle (PNP) platforms developed to counteract the recent COVID-19 pandemic-related severe acute respiratory syndrome coronavirus (SARS-CoV-2). The primary subjects of this article are the size, shape, cytotoxicity, and release mechanism of each nanoparticle. The two kinds of preparation methods in the synthesis of polymeric nanoparticles have been discussed: the first group uses premade polymers, while the other group depends on the direct polymerization of monomers. A few of the PNPs that have been utilized to combat previous viral outbreaks against SARS-CoV-2 are also covered.
mandado de segurança contra decisões jurisdicionais após o CPC/15
Authors: Fassbinder Eloisa , Galio Morgana Henicka
Published: May 2024

O mandado de segurança consiste em uma ação constitucional de natureza civil, sendo o meio pelo qual pessoas físicas ou jurídicas, também algumas entidades, impedem ou cessam condutas ilegais ou abusivas praticadas por pessoa física (autoridade) no exercício da função pública. O mandado de segurança surgiu com a Constituição Federal de 1934. Atualmente, está previsto no artigo 5º, incisos LXIX e LXX, da Constituição Federal, e regulamentado pela Lei n. 12.016/2009. Para a sua configuração são necessários alguns requisitos: a) direito líquido e certo, não amparado por habeas corpus ou habeas data; b) ato ilegal ou abusivo; c) autoridade pública ou agente de pessoa jurídica no exercício de funções públicas. A importância do mandado de segurança se verifica devido ao seu caráter de garantia fundamental constitucional.  Essa garantia exige do Estado uma postura mais ampliada, onde lhe são impostos deveres, como o de criar leis que estabeleçam seu procedimento, tornando-o mais célere, acessível e eficaz, além de conferir, ao mandado de segurança, uma interpretação sempre favorável ao seu cabimento, tramitação e efetivação. Portanto, conclui-se que o mandado de segurança é um instrumento constitucional de grande importância, utilizado para proteger direito líquido e certo, não amparado por habeas corpus ou habeas data, contra ato ilegal ou abuso de autoridade no exercício do poder público. A pesquisa utilizou o método de abordagem dedutivo em que pressupõe a razão com o intuito de chegar ao conhecimento verdadeiro e técnicas de pesquisa bibliográficas e documental, a partir de consulta à doutrina, legislação e julgados dos tribunais. Ao final, buscou-se analisar toda a questão procedimental do mandando de segurança, bem como, a evolução do mandado de segurança nos diplomas no ordenamento jurídico brasileiro, para que fosse possível avaliar sua utilização como meio de impugnação.
Ways of storing and using water: Experiences of uneven water scarcity in a water-rich region
Authors: Shah Rinan
Published: May 2024

Communities in Darjeeling town have been experiencing and coping with water scarcity for decades. Developmental history points towards fragmented governance and inefficient infrastructural interventions, which have led to uneven access to water defined by physical and political aspects at the household level. The outcomes of inequalities are reflected in the coping behavior and the ways of storing and using water. This work draws from urban political ecology (UPE), and it contributes to UPE studies by examining the physical, political, and infrastructural aspects of households in the production of unequal water scarcity. It furthers the need to add altitude while carrying out urban studies in the mountains as a driving factor for water accessibility. This essay is based on fieldwork carried out from 2014 until 2019 in Darjeeling town, which included topic-guided interviews, transect walks, unstructured interviews, document analysis, and household questionnaires.
Clinical features and outcomes of dogs with attempted medical management for discrete gastrointestinal foreign material: 68 cases (2018–2023)
Authors: Carrillo Alyssa J. , McCord Morgan A. , Dickerson Vanna M.
Published: May 2024

OBJECTIVE

To retrospectively describe clinical characteristics of canine gastrointestinal foreign bodies (GIFB) that were successfully and unsuccessfully managed conservatively.

ANIMALS

68 client-owned dogs presented to the Texas A&M Small Animal Teaching Hospital between January 1, 2018, and October 1, 2023, for GIFB where medical management was attempted.

CLINICAL PRESENTATION

Medical records were reviewed for signalment, history, physical examination, bloodwork, diagnostic imaging, foreign body type, location, treatments, and outcome. Success was defined as the passage of the foreign body through the colon, while failure was defined as requiring surgery, endoscopy, or euthanasia.

RESULTS

Medical management was successful in 32 cases (47%; 95% CI, 0.32 to 0.66). Gastric dilation resolved in all success cases (n = 5 [100%]; 95% CI, 0.32 to 2.3) but did not resolve in any failure cases (13 [0%]). Small intestinal dilation resolved in all success cases (n = 13 [100%]; 95% CI, 0.53 to 1.7) but progressed in most failure cases (9 [75%]; 95% CI, 0.34 to 1.4). In the success group, 31 GIFB were nonlinear (96.9%; 95% CI, 0.66 to 1.4), while 1 was linear (3.1%; 95% CI, 0.001 to 0.17). In the failure group, 29 GIFB were nonlinear (80.6%; 95% CI, 0.54 to 1.16), while 7 were linear (19.4%; 95% CI, 0.08 to 0.4). Of the cases that elected surgery (n = 29 [42.7%]; 95% CI, 0.29 to 0.61), resection and anastomosis was performed in 3 cases (10.3%; 95% CI, 0.02 to 0.3). All cases that required resection and anastomosis were nonlinear GIFB.

CLINICAL RELEVANCE

Conservative management of GIFB provides a feasible treatment option and may be considered based on presentation, foreign body location, hemodynamic stability of the patient, diagnostic imaging, and type of foreign body.
Taste-masking methods in multiparticulate dosage forms with a focus on poorly soluble drugs
Authors: Simšič Tilen , Planinšek Odon , Baumgartner Ana
Published: May 2024

In the past, the administration of medicines for children mainly involved changes to adult dosage forms, such as crushing tablets or opening capsules. However, these methods often led to inconsistent dosing, resulting in under- or overdosing. To address this problem and promote adherence, numerous initiatives, and regulatory frameworks have been developed to develop more child-friendly dosage forms. In recent years, multiparticulate dosage forms such as mini-tablets, pellets, and granules have gained popularity. However, a major challenge that persists is effectively masking the bitter taste of drugs in such formulations. This review therefore provides a brief overview of the current state of the art in taste masking techniques, with a particular focus on taste masking by film coating. Methods for evaluating the effectiveness of taste masking are also discussed and commented on. Another important issue that arises frequently in this area is achieving sufficient dissolution of poorly water-soluble drugs. Since the simultaneous combination of sufficient dissolution and taste masking is particularly challenging, the second objective of this review is to provide a critical summary of studies dealing with multiparticulate formulations that are tackling both of these issues.
Sedative load and anticholinergic burden among older adults in Slovenia over a decade: Potential for optimization of pharmacotherapy
Authors: Jazbar Janja , Locatelli Igor , Kos Mitja
Published: May 2024

This study investigates the 10-year trend in the sedative and anticholinergic burden among older adults in Slovenia, with the aim of identifying opportunities to optimize pharmacotherapy in this population. A retrospective drug utilization analysis was conducted based on a national anonymized database of dispensed prescriptions from 2009 to 2019. The study employed the sedative load model and the anticholinergic cognitive burden scale to assess the sedative and anti cholinergic burden, respectively. The findings indicate that in 2019, 45.6 % and 40.8 % of older adults (≥ 65 years) used sedative and anticholinergic medications, respectively. A high sedative load and a clinically significant anticholinergic burden were observed in a considerable proportion of older adults (13.2 % and 11.2 %, respectively, in 2019). The age-standardized prevalence of sedative load and anti-cholinergic burden significantly decreased over the 10-year study period by 5.6 % and 1.7 %, respectively (absolute difference), while the prevalence of clinically significant anticholinergic burden remained stable. Notably, the age groups 85–89 years and above 90 years had an increase in the proportion of individuals with a clinically significant anticholinergic burden over the years. These results emphasize the need for targeted interventions, particularly in the oldest age groups, to promote safe and effective medication use among older adults.
Clinicopathological parameters analysis of post-resection colorectal carcinoma in Cut Meutia General Hospital, North Aceh
Authors: Rahayu Mulyati Sri , Nadira Cut Sidrah , Sawitri Harvina , Maulina Nora , Sina Nabil Ibnu , Ramadhan Oriza Rifki
Published: May 2024

Introduction: Colorectal cancer is a malignancy that occurs in the colon and/or rectum and as the third most commonly diagnosed and second most fatal cancer globally.Objective : This study aimed to determine the relationship between the clinicopathological parameters of colorectal cancer.Methods: The research was retrospective cross-sectional study design. Data were collected from medical records of post-resection colorectal cancer patients during 2018-2021 at the Anatomical Pathology Laboratory Cut Meutia Hospital North Aceh based on the inclusion and exclusion criteria. A total sample size of 30 samples. The relationship between clinicopathological parameters was analyzed by Chi-square test.Results: Age was significantly associated with tumor size (p=0.01), grading (p=0.05) and depth of invasion (p=0.02). In addition, histological type was significantly associated with tumor location (p=0.05) and tumor size had a significant relationship with depth of invasion (p=0.05).Conclusion: The study indicates that clinicopathological parameters might underlie tumor progression and prognosis in colorectal carcinoma.
Ketahanan Beton Mutu Tinggi Berserat Abaka Menggunakan Tanah Diatomae Sebagai Substitusi Semen Terhadap Suhu Tinggi
Authors: Kautsar Muhammad Emil , Muttaqin, M.T Dr. Ir. , Saidi, M.Eng., IPU Dr. Ir. Taufiq
Published: May 2024

Beton mutu tinggi membutuhkan semen dalam jumlah besar untuk mencapai kuat tekan yang diinginkan dan juga rentan terhadap suhu tinggi. Salah satu alternatif untuk mengurangi pemakaian semen ialah penggunaan tanah diatomae sebagai substitusi semen dan penambahan serat abaka untuk mencegah peledakan struktur beton. Penelitian ini bertujuan untuk mengetahui pengaruh variasi substitusi tanah diatomae dan penambahan serat abaka dalam campuran beton mutu tinggi terhadap kuat tekan yang dipanaskan pada suhu 400°C, 500°C, dan 600°C. Dalam penelitian ini digunakan substitusi tanah diatomae dengan variasi 0% dan 10% dari berat semen dan penambahan serat abaka dengan variasi 0%; 0,15%; 0,30%; dan 0,45%. Digunakan FAS 0,3 dan superplasticizer sebesar 1,5% dari berat semen. Pengujian dilakukan pada umur beton 28 hari. Hasil penelitian menunjukkan bahwa dengan penambahan serat abaka dan substitusi tanah diatomae sebesar 10% dapat meningkatkan nilai kuat tekan. Kehilangan kuat tekan rata-rata terbesar pada variasi 0% dan 10% tanah diatomae berturut-turut 61% dan 53,36%.
Kajian Tingkat Risiko Kecelakaan Kerja pada Proyek Peningkatan Jalan Peurelak- Lokop – Batas Gayo Lues Menggunakan Metode FMEA
Authors: Birrabbah Bilal , Jamil Muhammad , Bulba Alfa Taras
Published: May 2024

Proyek konstruksi merupakan suatu kegiatan yang kompleks dan melibatkan banyak pihak yang terlibat dalam pelaksanaannya. Salah satu upaya untuk meningkatkan kualitas pelaksanaan proyek konstruksi adalah dengan menerapkan Sistem Manajemen Keselamatan Konstruksi. Tingkat kecelakaan kerja konstruksi terbilang cukup tinggi maka harus diterapkan Keselelamatan dan Kesehatan Kerja pada proyek konstruksi bertujuan yang untuk meningkatkan keselamatan dan kesehatan kerja di lokasi konstruksi, sehingga dapat mengurangi risiko kecelakaan dan cedera pada pekerja. Penelitian ini bertujuan untuk mengkaji tingkat risiko kecelakaan kerja pada Proyek Peningkatan Jalan Peurelak Lokop – Batas Gayo Lues  dan menentukan pekerjaan dengan tingkat risiko kecelakaan tertinggi. Metode yang digunakan dalam penelitian ini adalah survei melalui kuesioner, menggunakan sumber data primer dan sekunder. Kuesioner disusun berdasarkan variabel yang terkait dengan penerapan K3. Pengolahan data kuisioner dilakukan dengan menggunakan presentase skala Likert, sedangkan pengolahan data wawancara dilakukan dengan menggunakan metode FMEA ( Failure Mode Effect Analysis ). Hasil yang didapat dari penelitian ini variabel yang paling dominan yaitu variabel operasional dengan skor rata-rata sebesar 89.85%, dan nilai RPN (Risk Priority Number) dari 8 kecelakaan kerja yang berpotensi terjadi didapat pekerjaan pengangkutan material yang memiliki risiko kecelakaan kerja tertinggi yaitu dengan nilai RPN sebanyak 90,64.
Resiliensi Penyintas Bencana Gempa Bumi di Pidie Jaya Ditinjau dari Jenis Kelamin dan Usia
Authors: Ramadhan Ferry , Mawarpury Marty
Published: May 2024

Resiliensi merupakan kualitas individu yang memungkinkannya untuk menyesuaikan diri dengan stres yang ekstrem dan traumatis, kemudian akan kembali ke kondisi sebelumnya dan tampak kebal dari peristiwa-peristiwa kehidupan yang negatif. Resiliensi dapat dikaji berdasarkan faktor yang memengaruhinya seperti jenis kelamin dan usia. Penelitian ini bertujuan untuk mengetahui perbedaan resiliensi pada penyintas bencana gempa bumi di Pidie Jaya ditinjau dari jenis kelamin dan usia. Penelitian ini menggunakan metode kuantitatif dengan teknik pengambilan sampel purposive. Subjek dalam penelitian ini terdiri dari 163 laki-laki dan 163 subjek perempuan dan kelompok usia terdiri dari 76 subjek remaja, dan 88 subjek dewasa madya. Pengumpulan data menggunakan Connor Davidson Resilience Scale. Hasil analisis menggunakan Mann Whitney U Test menunjukkan nilai signifikasi 0,002 (p0,05) untuk kelompok jenis kelamin dan nilai signifikansi 0,000 (p0,05) untuk kelompok usia, artinya terdapat perbedaan resiliensi ditinjau dari jenis kelamin dan usia. Hasil ini menunjukkan berdasarkan jenis kelamin laki-laki lebih resilien dari pada perempuan dan pada kelompok usia, remaja lebih resilien dari pada dewasa madya. Resilience is a quality of a person that allows him/her to adapt to extreme and traumatic stress, then return to his/her previous condition and appear immunity from negative life events. Resilience can be studied based on influencing factors such as gender and age. This study aims to determine differences in resilience in earthquake survivors in Pidie Jaya in terms of gender and age. This research uses quantitative methods with purposive sampling techniques. Tthe subjects in this study consisted of 163 male and 163 female subjects and the age group consisted of 76 adolescents, and 88 middle adults. Data collection using the Connor Davidson Resilience Scale. The results of the analysis using the Mann Whitney U Test showed a significance value of 0.002 (p0.05) for the gender group and 0.000 (p0.05) for the age group, this means that there are differences in resilience in terms of gender and age.The results indicate that based on gender, men are more resilient than women and in the age group, adolescents are more resilient than middle adults.
Fatal case of EBV induced hemophagocytic lymphohistiocytosis (HLH), presenting with acute abdomen
Authors: Abdelmesih Gina
Published: May 2024

Introduction :
Hemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory syndrome with excessive immune activation. Primary or secondary HLH, have a high mortality rate approaching 50%, despite multiple management regiments. In adults, infections, especially EBV, and hematological malignancies are the most common causes. HLH recognition is often delayed, due to unfamiliarity of physicians of this diagnosis. Scores are available to aid physicians recognize HLH, but can be applied if the diagnosis is suspected.
Case description:
40 years old male, from Sierra Leon, presented to the emergency with acute abdomen. Patient had high grade fever, generalized abdominal pain and vomiting. Initial investigations showed massive hepatosplenomegaly, monocytosis, thrombocytopenia, deranged LFT. Patient admitted as a case of acute cholecystitis. Patient was started on broad spectrum antibiotics but failed to improve and continued to rapidly deteriorate requiring intubation and inotropic support in ICU. Patient was managed as a case of septic shock and underwent open cholecystectomy, however the excised gall bladder couldn't explain the patient's clinical picture. HLH was considered at that phase as supported by additional findings of hypertriglyceridemia, hypofibrinogenemia, hyperferritinemia, thrombocytopenia. Pulse steroids therapy was initiated, with an initial response followed by relapse of condition. Patient transferred to a facility with hematology service for continuity of care and bone marrow biopsy. Serology showed Positive EBV IgM with EBV DNA found to be 1260000000 copies/mL. Patient continued to deteriorate with multiple organ failure and remained unstable on maximum inotropic support and HLH management. Patient had an asystolic cardiac arrest and despite all effort, patient was declared dead on day 23 of hospital admission.
Conclusion:
HLH is an underdiagnosed entity in the critically ill patients, often missed or misdiagnosed as sepsis or DIC. Physicians needs to be aware of its causes and pathogenesis for early recognition and appropriate treatment. Multiple organ dysfunction can rapidly develop. No documented prognostic indicator can alarm the physician of the developing HLH and therefore HLH should be considered in all critically ill patients. If suspected, patient should be followed and managed by a hematology service, and if unavailable, prompt transfer is needed as bone marrow biopsy and flow cytometry are needed for the diagnosis. Steroids therapy and etoposide are usually initiated once diagnosis is established. Cyclosporine is also used but high risk of developing PRES if CNS involvement by HLH is present. Despite multiple proposed drug regimen, mortality remains very high, and increases as the diagnosis is delayed.
The antecedents of purchase intention on healthy instant noodle products: Is it worth fighting for?
Authors: Alamanda Dini Turipanam , Wibowo Lili Adi , Disman Disman , Anggadwita Grisna
Published: May 2024

Instant noodles are one of the favorite foods in Indonesia. Many food and beverage companies compete to attract consumer interest by providing promotions for various flavors of instant noodle products. The health issue of instant noodle products has become a concern for business owners who want to provide healthier food. However, the importance of healthy food has yet to receive a positive and significant response from Indonesian consumers. Increasing consumer interest in healthy food in Indonesia is crucial since it can significantly affect public health. This study aims to measure the effect of convenience, advertising, subjective norms, and product attributes as antecedents of people's purchase intention for healthy instant noodle products. This research used a quantitative approach by distributing questionnaires to respondents selected through a purposive sampling technique based on the criteria: consumers of healthy instant noodle products who have previously purchased instant noodles or a variety of healthy instant noodles. A total of 210 respondents participated in filling out this research questionnaire. Partial least squares structural equation modeling (PLS-SEM) was used as an analytical technique. The results of this study indicate that subjective norms are not proven to be an antecedent that affects consumer purchase intentions for healthy instant food products. In contrast, product attributes are the most influential antecedent. This study provides academic implications by adding literature on the antecedents of people's purchase intentions for healthy instant noodle products. The practical implications, especially for business owners, are shown by helpful information to improve campaigns, promotions, and product sales.
Keywords—Consumer behavior; Healthy instant noodles; Marketing management; Purchase intention
Digitalization of SMEs to Survive Amid The Pandemic
Authors: Purba Abdul Rahman Sutara , Balqiah Tengku Ezni
Published: May 2024

The purpose of the research conducted was to understand the relationship of internal factors of SME digitalization on the company's financial performance during the pandemic to test 5 hypotheses. This study used a survey method, questionnaires to get respondents' answers. A purposive technique was used and managed to collect 359 respondents who had small to medium medium-scale businesses. Furthermore, the research model was tested statistically with PLS-SEM analysis techniques. Based on the results of data processing and analysis, it is proven that all hypotheses are acceptable, which shows that the internal factors of digitalization of SME companies, namely information and technology, employee skills, and digital strategies, have a positive and significant effect on the digitalization of SME companies. Furthermore, digitalization affects the company's financial performance where employee skills have the largest variable of the three factors. Digitalization is able to mediate the influence of information and technology, employee capabilities, and digital strategies on the financial performance of SMEs. This result shows that digitalization is also important, especially during a pandemic where SMEs must adapt to technology so that they can survive by maintaining their business performance. These findings add to the empirical development of literature on SME digitization factors such as information and technology, employee skills, and digital strategies. In addition, this study also provides an understanding of how much influence these three factors can affect the digitalization of SMEs. Keywords— Digitalization; Employee Skill; Financial Performance; Information and Technology; SMEs
The Impact of Entrepreneurial Strategy on the Firm Performance of Indonesian Technology Startups
Authors: Triono Sunu Puguh Hayu , Rahayu Agus , Wibowo Lili Adi , Alamsyah Andry
Published: May 2024

Changes in the business environment, driven by technology and globalization, increase the urgency of a strategic orientation for new ventures and, conversely, an entrepreneurial orientation for established firms. Technology startups, as "innovation machines," face unique challenges related to the environment, competition, and resource limitations. Therefore, they need to be more strategic in conducting their business. Entrepreneurial strategy is a new strategic framework specifically formulated for startups. However, the effect of this strategy on firm performance has not been confirmed. This study investigates the relationship of entrepreneurial strategy on the tech startup’s firm performance. A conceptual model was developed based on the strategic management framework, including strategy formulation, implementation, and evaluation. The data was collected via an online survey and was able to gather 39 respondents, dominated by the fields of SaaS, Edutech, and health tech. The data was then analyzed using SmartPLS software. The analysis showed that entrepreneurial strategy has a positive effect on firm performance, value offering (value-based strategy), and innovation ambidexterity. Further analysis found that there was no significant mediation effect or indirect relationship. Additionally, the predictability analysis found that the structural model in this study has moderate predictability power. The results of this study contribute to the strategic entrepreneurship field by providing evidence of how entrepreneurial strategy can improve tech-startup firm performance. Lastly, the limitations in this study can provide new opportunities for future research, especially related to objects, operationalization, and conceptual models. Keywords— Entrepreneurial Strategy; Innovation Ambidexterity; Offered Value; Startup’s Firm Performance; Strategic Entrepreneurship
The Effectiveness of The Use of E-Commerce and Digital Payment on Brand Awareness of Private Regional Drinking Water Companies (PDAM)
Authors: Dedi Dedi , Frihatini Farida , Kusnadi Yadi
Published: May 2024

Customer satisfaction is the main focus of the company to increase Brand Awareness, influence company value, and achieve goals. This study aims to evaluate the effectiveness of E-commerce and Digital Payment on Brand Awareness and customer satisfaction at private PDAMs. Quantitative methods were used with a sample of 98 customers and multiple linear regression analysis. The results showed that E-commerce and Digital Payment partially positively affected Brand Awareness, with t values of 4.416 and 4.656, respectively (value > t table). Simultaneously, both factors have a positive effect on Brand Awareness, with a calculated f value of 29,979 (value> f table) and a significance level of 0.000. E-commerce and Digital Payment together contribute 38.7% to increasing Brand Awareness (R square 0.568), while the rest is influenced by other factors not included in this study. Keywords— Brand Awareness; E-commerce; Digital Payment; Customer Satisfaction
أثر العِلل العقليّة في تفسير الظّواهر النّحْويَّة
Authors: أنــــور وعـــد دليـــان
Published: May 2024

تتجه هذه الدراسة لإظهار جهود النحاة وغاياتهم المقصودة والوصول الى مناهجهم التي اعتمدوا عليها في بيان العلل العقلية في إثبات صحة القواعد النحوية وقبولها عندهم .
          وقد تشكلت معالم هذه القضية عندما أقبلوا على توظيف العِلل العقلية في تفسير الظواهر النحوية وإيجاد حلول ومعالجات لكثير مما كانت توصف بالغموض ويشوبها الاحتمال ، والخروج عن الأصول ، وكان ذلك يقف عائقاً أمام فهم النصوص وبلوغ مقاصدها .
وبناءً على ذلك انطلقت فكرة البحث للوقوف على تلك الظواهر عن طريق الاستعانة بالعِلل العقلية وكانت نتيجة هذا التأمل فيها مذهلة، فضلاًعن خدمتها  للنصوص أنها كشفت عن دقة استعمال النحاة لتلك العِلل العقلية ، وبراعة اختيارهم لها ، وحدّة ذكائهم فيها ، وهذا يدعنا لإدراك قضية مفادها أنّ العرب أمة حكيمة تقصد العقل لجعله منطلقا لفهم العلوم اللغوية عامة ومن بينهاعلم النحو على وجه الخصوص.
الاتحاد الاوروبي محرك القوة الاقتصادية ما بين عامي (١٩٩١-٢٠٠١م)
Authors: سامي شهد حسام
Published: May 2024

اثار الاتحاد الاوروبي حديث الكثير من المهتمين في الشؤون الدولية لما خطاه من الخطوات نحو التوسع والاندماج الاقتصادي والتي انعكست على المنظور الجماعي الاوروبي وكبديل اقتصادي لدفع وانعاش نشاطها الاقتصادي والتجاري ولضمان اندماجها الايجابي في سير الاقتصاد العالمي،كما قرب الاتحاد الاوروبي بين كل التكتلات الاقتصادية العالمية الراهنه والتنبوء بمستقبل القرن الحادي والعشرين مع تتبع مسيرة التكامل والاندماج الاوروبي في الماضي والحاضر ، ففي عام 1992 اتفقت دول المجموعة الأوروبية على إنشاء السوق الأوروبية الموحدة، وبمقتضى ذلك لم يقتصر الأمر على إلغاء الحواجز المادية، بل تضمن الاتفاق على إزالة القيود غير المنظورة، وكذلك تم الاتفاق على التنسيق النقدي بين عملات دول الجماعة الأوروبية في خطوات متعددة فيما عرف بالاتحاد الاقتصادي والنقدي وهذا ما سوف نراه لاحقا، و أمام زيادة الدعوة لحرية انتقال رؤوس الأموال والخدمات المالية تم التوقيع على معاهدة ماستريخت والتي بمقتضاها تم تحويل الجماعة الأوربية إلى الاتحاد الأوروبي ، وفي الحديث عن دور الاتحاد الأوروبي في الاقتصادي العالمي فقد عد عملاق الاقتصاد تثميناً لدوره في تحريك العجلة الاقتصادية.
Pengendalian Kualitas Produk 456 DI PT DME
Authors: Novita Sari Dian , Budi Trisnanto Teguh , Noer Irmayani
Published: May 2024

PT DME merupakan salah satu perusahaan yang memproduksi udang mentah beku, udang masak beku dan produk bernilai tambah (value added). Tujuan dari penulisan tugas akhir ini untuk (1) Mendeskripsikan alur proses produksi 456 di PT DME (2) Pengendalian Kualitas produk 456 pada proses produksi di PT DME. Metode analisis data yang digunakan yaitu metode deskriptif untuk menjelaskan proses produksi  456 dan faktor penyebab kerusakan produk 456 pada proses produksi  menggunakan alat bantu diagram alir,  histogram, dan fishbone. Diagram alir digunakan sebagai alat untuk menjelaskan alur proses produksi produk 456 dimulai dari tahapan penerimaan bahan baku dan bahan pelapis, produksi, dan pengemasan. Histogram dan fishbone digunakan sebagai alat untuk mengidentifikasi masalah yang paling banyak terjadi kerusakan produk dan mengetahui faktor penyebab kerusakan produk 456  yang tidak sesuai dengan standar perusahaan.
A pilot study on the antimicrobial efficacy of Coleus Aromaticus on Lactobacillus acidophilus – Comparative In-Vitro analysis of five samples on a single plate
Authors: Krishnan B. Sai , Chakravarthy Yadav , Jacob Mathew
Published: May 2024

Objectives:

Coleus aromaticus, also known as Indian borage, is a plant recognized for its medicinal uses, including potential antimicrobial properties. Lactobacillus acidophilus, a bacterium commonly found in the oral cavity and gastrointestinal tract, plays a crucial role in maintaining microbial balance but can lead to dental caries if imbalanced. The aim of this study is to assess the in vitro antimicrobial efficacy of C. aromaticus against L. acidophilus.

Material and Methods:

The study was performed by the utilization of homeopathic ethanolic and dry leaf extracts of C. aromaticus on Lactobacillus bacteria, with a control group treated with 0.2% chlorhexidine. For the preparation of the C. aromaticus extract, leaves were cleaned, dried, and ground into a paste. A 20 g portion of this paste was then weighed and used for extraction. In the assessment of inhibitory effects, the disc diffusion method was employed, and nutrient agar served as the growth medium. Discs loaded with the respective extracts were positioned on the agar, and the Petri dishes were subsequently incubated at 37°C for 24 h. Following the incubation period, the inhibitory zones surrounding the discs were measured using a measuring scale.

Results:

The study’s findings were determined by measuring the diameter of inhibition zones and assessing the mean values. It was observed that the aqueous extract derived from dried C. aromaticus leaves possesses antimicrobial activity against Lactobacillus. Specifically, it exhibited inhibition zones with diameters of 24 mm and 27 mm when using 100 µL/disc and 200 µL/disc, respectively. In comparison, the control group (0.2% chlorhexidine) displayed an inhibitory zone with a 23 mm diameter.

Conclusion:

The reason for these findings could be attributed to the existence of phytochemicals and essential volatile oils within C. aromaticus, which possess antimicrobial properties against Lactobacillus. This natural component appears to be effective in reducing Lactobacillus growth when used as an oral rinse containing phytochemicals.
Encyclopedia of Russian Villages: Past and Present
Authors: Stepanova Natalya V. , Averyanov Konstantin A. , Melnichuk Gennadiy A. , Rasskazova-Nikolaeva Svetlana A.
Published: May 2024

The article reports on the 17th scientific and practical conference “Rural Russia: Past and Present”, organized by the scientific research and cultural and educational society “Encyclopedia of Russian Villages” and the A.A. Nikonov All-Russian Institute of Agrarian Problems and Informatics (held on October 24, 2023 at the Faculty of Economics of M.V. Lomonosov Moscow State University). The geography of the participants covers many regions of the Russian Federation (from the Arkhangelsk Region in the north to the Republic of Crimea in the south, from the Pskov Region in the west and to the Primorsky Territory in the east). Traditionally, the scientific forum aims at a comprehensive local history study of the past and present of our Fatherland. The sources of the reports were numerous materials from the collections of libraries, museums, archives, as well as regional periodicals and bibliographic indexes.
Badanie świadomości językowej mieszkańców Poznania – germanizmy we współczesnej gwarze poznańskiej
Authors: Szymańska-Galińska Karina
Published: May 2024

Celem artykułu było zbadanie świadomości językowej mieszkańców Poznania w odniesieniu do germanizmów występujących we współczesnej gwarze poznańskiej. Badanie oparto na anonimowym kwestionariuszu ankiety, w którym udział wzięło 104 respondentów, w trzech grupach wiekowych. Analiza zweryfikowała czynną i bierną znajomość zapożyczeń niemieckich wśród ankietowanych oraz ich wiedzę na temat etymologii i występowania badanych jednostek pod względem ilościowym. Zbadano stosunek do germanizmów i ich żywotność ze wskazaniem grup wiekowych, warstw społecznych i sytuacji, w których używane są najczęściej. Przeprowadzone badanie zestawione zostało z wynikami analizy przeprowadzonej w 2015 roku przez Annę Piotrowicz i Małgorzatę Witaszek-Samborską, która była przedmiotem publikacji O żywotności zapożyczeń niemieckich w gwarze miejskiej Poznania.
The invisible footprint of climbing shoes: high exposure to rubber additives in indoor facilities
Authors: Sherman Anya , Masset Thibault , Wimmer Lukas , Dailey Lea Ann , Hüffer Thorsten , Breider Florian , Hofmann Thilo
Published: May 2024

There is increasing research focused on rubber additives, predominantly originating from tire and road wear particles. Other consumer products including sports equipment also contain rubber additives and the overall human exposure to these compounds is of concern due to demonstrated toxicity to animal species. Rubber additives are intentionally incorporated into climbing shoes for specific performance. We found high concentrations of rubber additives in shoe sole samples, aerosol particulate matter, and settled dust in indoor climbing halls. The estimated daily intake via inhalation for climbers and employees of these facilities exceeds the intake of rubber additives from all other known sources. Abrasion powder resulting from friction of climbing shoes on the holds is responsible for the high concentrations of rubber additives observed in aerosol particulate matter and settled dust, while other emission sources could be excluded. We also show that atmospheric transformation of rubber additives occurs in indoor environments. These findings identify a previously unknown human exposure route to rubber additives and emphasize the global problem of the toxicity burden of plastic additives.
Effect Of Tax Knowledge On Individual Taxpayers Compliance
Authors: Damajanti Anita , Karim Abdul
Published: May 2024

Indonesia uses self-assessment system in income tax collection. This system requires the taxpayer to understand the method of calculating payments and tax reporting in accordance with applicable regulations. The problem faced by many taxpayers who do not understand the tax laws. Taxpayers who do not understand tax law become an obstacle for the implementation of self-assessment system in the collection of income tax. This study will examine empirically the influence of tax knowledge on tax compliance of individuals enrolled in the Tax Office (KPP) Central Java Region I. This study develops previous studies that have been carried out in Indonesia by separating variable tax knowledge into 3 (three) variables i.e. knowledge of tax reporting, tax calculation knowledge, and knowledge of tax payments.Data were collected using a questionnaire that is sent directly to the taxpayer. Questionnaires were sent as many as 200 copies. A total of 196 copies of the completed and can be processed. The test results indicate that the instruments used in this study are valid and reliable. Results of hypothesis testing using regression provides empirical evidence that knowledge of tax reporting, tax calculation and knowledge of tax payments significant effect on tax compliance.
Motor Vehicle Tax Compliance Levels: An Empirical Study And The Determining Factors
Authors: Surjanti Lulus Prapti N. S. , Nugroho Dwi Widi Pratito Sri , Sulistyawati Ardiani Ika
Published: May 2024

Tax is the biggest income for the state and one of taxes which imposed on taxpayers is motor vehicle tax. Normatively, for all citizens who have fulfilled the requirements as taxpayers and have motor vehicles, they should not forget to pay the tax. But in reality, there are still many taxpayers who have not complied and fulfilled their tax obligations. The aim of this study is to analyze the effect of the application of administrative penalty, awareness of taxpayers, interest rates on tax penalties, and tax payment procedure on the level of taxpayer compliance. We used accidental sampling method on motor vehicles tax payer to determine the sample. There are 144 taxpayer respondents who are willing to participate and whose data can be processed. Multi linear regression was used to test the hypothesis. The findings of this study indicate that the interest rates on tax penalties have the greatest influence on motor vehicle taxpayer compliance. While the awareness factor of taxpayers actually has the smallest influence on taxpayer compliance.