bluuebunny/crossref_metadata_2025 huggingface dataset:
Synaptotagmins family affect glucose transport in retinal pigment epithelial cells through their ubiquitination-mediated degradation and glucose transporter-1 regulation
Authors: Xu Hong , Zhang Li-Bo , Luo Yi-Yi , Wang Ling , Zhang Ye-Pin , Chen Pei-Qi , Ba Xue-Ying , Han Jian , Luo Heng
Published: May 2024

BACKGROUND

Synaptotagmins (SYTs) are a family of 17 membrane transporters that function as calcium ion sensors during the release of Ca2+-dependent neurotransmitters and hormones. However, few studies have reported whether members of the SYT family play a role in glucose uptake in diabetic retinopathy (DR) through Ca2+/glucose transporter-1 (GLUT1) and the possible regulatory mechanism of SYTs.

AIM

To elucidate the role of the SYT family in the regulation of glucose transport in retinal pigment epithelial cells and explore its potential as a therapeutic target for the clinical management of DR.

METHODS

DR was induced by streptozotocin in C57BL/6J mice and by high glucose medium in human retinal pigment epithelial cells (ARPE-19). Bioinformatics analysis, reverse transcriptase-polymerase chain reaction, Western blot, flow cytometry, ELISA, HE staining, and TUNEL staining were used for analysis.

RESULTS

Six differentially expressed proteins (SYT2, SYT3, SYT4, SYT7, SYT11, and SYT13) were found between the DR and control groups, and SYT4 was highly expressed. Hyperglycemia induces SYT4 overexpression, manipulates Ca2+ influx to induce GLUT1 fusion with the plasma membrane, promotes abnormal expression of the glucose transporter GLUT1 and excessive glucose uptake, induces ARPE-19 cell apoptosis, and promotes DR progression. Parkin deficiency inhibits the proteasomal degradation of SYT4 in DR, resulting in SYT4 accumulation and enhanced GLUT1 fusion with the plasma membrane, and these effects were blocked by oe-Parkin treatment. Moreover, dysregulation of the myelin transcription factor 1 (Myt1)-induced transcription of SYT4 in DR further activated the SYT4-mediated stimulus-secretion coupling process, and this process was inhibited in the oe-MYT1-treated group.

CONCLUSION

Our study reveals the key role of SYT4 in regulating glucose transport in retinal pigment epithelial cells during the pathogenesis of DR and the underlying mechanism and suggests potential therapeutic targets for clinical DR.
Polycytosine RNA-binding protein 1 regulates osteoblast function via a ferroptosis pathway in type 2 diabetic osteoporosis
Authors: Ma Hong-Dong , Shi Lei , Li Hai-Tian , Wang Xin-Dong , Yang Mao-Wei
Published: May 2024

BACKGROUND

Recently, type 2 diabetic osteoporosis (T2DOP) has become a research hotspot for the complications of diabetes, but the specific mechanism of its occurrence and development remains unknown. Ferroptosis caused by iron overload is con-sidered an important cause of T2DOP. Polycytosine RNA-binding protein 1 (PCBP1), an iron ion chaperone, is considered a protector of ferroptosis.

AIM

To investigate the existence of ferroptosis and specific role of PCBP1 in the development of type 2 diabetes.

METHODS

A cell counting kit-8 assay was used to detect changes in osteoblast viability under high glucose (HG) and/or ferroptosis inhibitors at different concentrations and times. Transmission electron microscopy was used to examine the morphological changes in the mitochondria of osteoblasts under HG, and western blotting was used to detect the expression levels of PCBP1, ferritin, and the ferroptosis-related protein glutathione peroxidase 4 (GPX4). A lentivirus silenced and overexpressed PCBP1. Western blotting was used to detect the expression levels of the osteoblast functional proteins osteoprotegerin (OPG) and osteocalcin (OCN), whereas flow cytometry was used to detect changes in reactive oxygen species (ROS) levels in each group.

RESULTS

Under HG, the viability of osteoblasts was considerably decreased, the number of mitochondria undergoing atrophy was considerably increased, PCBP1 and ferritin expression levels were increased, and GPX4 expression was decreased. Western blotting results demonstrated that infection with lentivirus overexpressing PCBP1, increased the expression levels of ferritin, GPX4, OPG, and OCN, compared with the HG group. Flow cytometry results showed a reduction in ROS, and an opposite result was obtained after silencing PCBP1.

CONCLUSION

PCBP1 may protect osteoblasts and reduce the harm caused by ferroptosis by promoting ferritin expression under a HG environment. Moreover, PCBP1 may be a potential therapeutic target for T2DOP.
O Espírito Santo e o feminino
Authors: Milanez Teresinha
Published: May 2024

O Espírito Santo e o feminino
O Batismo no Espírito
Authors: Pereira Ney Brasil
Published: May 2024

O Batismo no Espírito
O Espírito Santo e as seitas
Authors: Wolff Elias
Published: May 2024

O Espírito Santo e as seitas
Pentecostalismo da prosperidade
Authors: Vignoli Márcio Alexandre
Published: May 2024

Pentecostalismo da prosperidade
A justiça e a paz na DSI
Authors: Vicente Vilmar Adelino
Published: May 2024

A justiça e a paz na DSI
Só o Cristo, a Verdade, liberta (Jo 8,32)
Authors: Pereira Ney Brasil
Published: May 2024

Só o Cristo, a Verdade, liberta (Jo 8,32)
Recensão
Authors: Longo Pedro
Published: May 2024

Recensão
“Olharão para aqueles que transpassaram” (Jo 19,37)
Authors: Scheid Eusébio Oscar
Published: May 2024

“Olharão para aqueles que transpassaram” (Jo 19,37)
A fé de Jesus. Anotações sócio-analíticas.
Authors: Vicente Vilmar Adelino
Published: May 2024

A fé de Jesus. Anotações sócio-analíticas.
A perspectiva sócio-ecológica dos sacramentos na teologia da América Latina
Authors: Wolff Elias
Published: May 2024

A perspectiva sócio-ecológica dos sacramentos na teologia da América Latina
Um só é vosso Mestre (Mt 23,8)
Authors: Pereira Ney Brasil
Published: May 2024

Um só é vosso Mestre (Mt 23,8)
Família: cenáculo de educação na Fé
Authors: Pereira Nereu do Vale
Published: May 2024

Família: cenáculo de educação na Fé
Apontamentos para uma Teologia da Linguagem
Authors: Vieira Paulo Medeiros
Published: May 2024

Apontamentos para uma Teologia da Linguagem
Igreja em Santa Catarina
Authors: Diversos Autores
Published: May 2024

Igreja em Santa Catarina
Correio do leitor
Authors: Diretor Editor
Published: May 2024

Correio do leitor
Guiados pelo Espírito, no Sacramento da Ordem
Authors: Francisco Manoel João
Published: May 2024

Guiados pelo Espírito, no Sacramento da Ordem
Palavra e Espírito
Authors: Cipriani Vitório
Published: May 2024

Palavra e Espírito
Memória, caminhada, sonho, compromisso, em Lucas
Authors: Loraschi Celso
Published: May 2024

Memória, caminhada, sonho, compromisso, em Lucas
O Espírito da Unidade Cristã
Authors: Wolff Elias
Published: May 2024

O Espírito da Unidade Cristã
Ciência e Deus no mundo atual
Authors: Brighenti Agenor
Published: May 2024

Ciência e Deus no mundo atual
O desemprego é inevitável?
Authors: Cardoso José Alvaro
Published: May 2024

O desemprego é inevitável?
Revolução tecnológica e desemprego: qual a relação?
Authors: Shiroma Oto Eneida
Published: May 2024

Revolução tecnológica e desemprego: qual a relação?
Educação profissional no campo: a empregabilidade da pequena produção rural
Authors: Bollmann Maria da Graça , Sepulveda Gusatvo Adolfo
Published: May 2024

Educação profissional no campo: a empregabilidade da pequena produção rural
Em direção ao próximo milênio: desafios do desemprego
Authors: Lemoine Georges , Queiroz Antônio Diomário de
Published: May 2024

Em direção ao próximo milênio: desafios do desemprego
Uma crítica a razão neoliberal
Authors: Assmann Selvino José
Published: May 2024

Uma crítica a razão neoliberal
Do desemprego aos desempregados
Authors: Ribeiro Hélcion
Published: May 2024

Do desemprego aos desempregados
Deus Pai e o sofrimento do mundo
Authors: Feller Vitor Galdino
Published: May 2024

Deus Pai e o sofrimento do mundo
O Sacramento da Reconciliação – perspectivas teológico-pastorais
Authors: Goedert Valter Maurício
Published: May 2024

O Sacramento da Reconciliação – perspectivas teológico-pastorais
Reconciliação, perdão e justiça
Authors: Pereira Ney Brasil
Published: May 2024

Reconciliação, perdão e justiça
As novas exigências do ensino religioso
Authors: Giustina Elias Della
Published: May 2024

As novas exigências do ensino religioso
Por um milênio sem exclusões
Authors: Neutzling Inácio
Published: May 2024

Por um milênio sem exclusões
Quando chega o bispo. A Igreja em SC em 1914.
Authors: Souza Rogério Luis de
Published: May 2024

Quando chega o bispo. A Igreja em SC em 1914.
Correios
Authors: Diversos Autores
Published: May 2024

Correios
Achegas sobre a Bernunça
Authors: Pereira Nereu do Vale
Published: May 2024

Achegas sobre a Bernunça
Comunhão Trinitária, modelo fundante da integração pessoal
Authors: Francisco Manoel João
Published: May 2024

Comunhão Trinitária, modelo fundante da integração pessoal
Por uma globalização da solidariedade. O problema da Dívida Externa à luz da Trindade
Authors: Brighenti Agenor
Published: May 2024

Por uma globalização da solidariedade. O problema da Dívida Externa à luz da Trindade
Entre a História... e a Escatologia
Authors: Muller Victor Clemente
Published: May 2024

Entre a História... e a Escatologia
A Campanha da Fraternidade 2001: Vida, sim, drogas não!
Authors: Momm Nilo
Published: May 2024

A Campanha da Fraternidade 2001: Vida, sim, drogas não!
Vida, sim, vida em abundância. O tema da vida nos escritos de São João
Authors: Pereira Ney Brasil
Published: May 2024

Vida, sim, vida em abundância. O tema da vida nos escritos de São João
Drogas e imaginário social
Authors: Neves Luciana
Published: May 2024

Drogas e imaginário social
A universidade como espaço alternativo de tratamento da dependência química
Authors: Paula Wilson Kraemer de
Published: May 2024

A universidade como espaço alternativo de tratamento da dependência química
Algumas experiências
Authors: Diversos Autores
Published: May 2024

Algumas experiências
Enculturação e endoculturação da Igreja. Condição para uma eclesiologia inculturada
Authors: Brighenti Agenor
Published: May 2024

Enculturação e endoculturação da Igreja. Condição para uma eclesiologia inculturada
A mulher e os ministérios na Igreja
Authors: Marques Gertrude
Published: May 2024

A mulher e os ministérios na Igreja
Tempo e tradição na cultura Guarani
Authors: Meliá Bartolomeu
Published: May 2024

Tempo e tradição na cultura Guarani
A colegialidade episcopal no interior da CNBB
Authors: Lorscheider Aloísio
Published: May 2024

A colegialidade episcopal no interior da CNBB
O evento Vaticano II e sua recepção na Igreja Local O testemunho de padres conciliares da CNBB
Authors: Brighenti Agenor
Published: May 2024

O evento Vaticano II e sua recepção na Igreja Local O testemunho de padres conciliares da CNBB
Igreja: povo de servidores O Serviço de Animação Vocacional da CNBB
Authors: Oliveira José
Published: May 2024

Igreja: povo de servidores  O Serviço de Animação Vocacional da CNBB
Como vi e vivi o Concílio e o Pós-Concílio
Authors: Diversos Autores
Published: May 2024

Como vi e vivi o Concílio e o Pós-Concílio
Lumen Gentium: retorno às fontes
Authors: Feller Vitor
Published: May 2024

Lumen Gentium: retorno às fontes
Pontos de vista do discurso bioético
Authors: Silva Márcio Bolda da
Published: May 2024

Pontos de vista do discurso bioético
Mística e espiritualidade das pastorais sociais
Authors: Dacoregio Elisete , Rosa Marcio , Favarin Roque
Published: May 2024

Mística e espiritualidade das pastorais sociais
A espiritualidade no contexto migratório – elementos que norteiam a experiência de um povo a caminho
Authors: Candaten Analita
Published: May 2024

A espiritualidade no contexto migratório – elementos que norteiam a experiência de um povo a caminho
A espiritualidade conjugal
Authors: Martendal Carlos
Published: May 2024

A espiritualidade conjugal
Espiritualidade integral
Authors: Casaldáliga Pedro
Published: May 2024

Espiritualidade integral
Sessão Solene da Assembleia Legislativa do Estado de Santa Catarina pela passagem do centenário da ‘Diocese” de Florianópolis
Authors: Krieger Murilo
Published: May 2024

Sessão Solene da Assembleia Legislativa do Estado de Santa Catarina pela passagem do centenário da ‘Diocese” de Florianópolis
Santa Catarina: um estado de contrastes – realidade social, econômica, cultural e política
Authors: Iunskovski Roberto
Published: May 2024

Santa Catarina: um estado de contrastes – realidade social, econômica, cultural e política
O diaconato permanente em foco
Authors: Goedert Valter Maurício
Published: May 2024

O diaconato permanente em foco
Perfil de Deus nos salmos
Authors: Stadelmann Luis
Published: May 2024

Perfil de Deus nos salmos
“Semitas espirituais”: a contribuição ode Thomas Merton ao diálogo inter-religioso judaico-cristão
Authors: Bertelli Getúlio
Published: May 2024

“Semitas espirituais”: a contribuição ode Thomas Merton ao diálogo inter-religioso judaico-cristão
O ecumenismo em Paulo
Authors: Wolff Elias
Published: May 2024

O ecumenismo em Paulo
Considerações sobre o perfil do presbítero no Documneto de Aparecida
Authors: Raschietti Stefano
Published: May 2024

Considerações sobre o perfil do presbítero no Documneto de Aparecida
As CEBs no Documento de Aparecida
Authors: Coutinho Sérgio Ricardo
Published: May 2024

As CEBs no Documento de Aparecida
A opção pelos pobres no Documento de Aparecida
Authors: Loraschi Celso
Published: May 2024

A opção pelos pobres no Documento de Aparecida
Discípulos migrantes e migrantes missionários: Elementos de pastoral da mobilidade humana a partir do Documento de Aparecida
Authors: Lussi Carmen
Published: May 2024

Discípulos migrantes e migrantes missionários: Elementos de pastoral da mobilidade humana a partir do Documento de Aparecida
Homilia que Dom Murilo S. R. Krieger, Arcebispo Metropolitano de Florianópolis, faria dia 23 de novembro de 2008, na celebração de encerramento do centenário da ‘Diocese” de Florianópolis
Authors: Krieger Murilo
Published: May 2024

Homilia que Dom Murilo S. R. Krieger, Arcebispo Metropolitano de Florianópolis, faria dia 23 de novembro de 2008, na celebração de encerramento do centenário da ‘Diocese” de Florianópolis
A mulher em Paulo
Authors: Pereira Ney Brasil
Published: May 2024

A mulher em Paulo
Recensão
Authors: Pereira Ney Brasil
Published: May 2024

Recensão
Pedro – João Paulo II – Rocha e pastor
Authors: Pereira Ney Brasil
Published: May 2024

Pedro – João Paulo II – Rocha e pastor
Acenos históricos do Regional Sul IV
Authors: Giustina Elias Della
Published: May 2024

Acenos históricos do Regional Sul IV
A vida religiosa em Santa Catarina – duas intuições
Authors: Besen José Artulino
Published: May 2024

A vida religiosa em Santa Catarina – duas intuições
A responsabilidade social do Teólogo
Authors: Wolff Elias
Published: May 2024

A responsabilidade social do Teólogo
Moradia, condição para a cidadania
Authors: Groh Vilson
Published: May 2024

Moradia, condição para a cidadania
Existe um teto além
Authors: Silva Carlos
Published: May 2024

Existe um teto além
Evangelização e inculturação
Authors: Crimella Severino
Published: May 2024

Evangelização e inculturação
A pneumatologia de Santo Domingo
Authors: Brandes Orlando
Published: May 2024

A pneumatologia de Santo Domingo
A formação presbiteral e o desafio da cultura
Authors: Cuénot Michel
Published: May 2024

A formação presbiteral e o desafio da cultura
“Sabedoria e política”
Authors: Pereira Ney Brasil
Published: May 2024

“Sabedoria e política”
“Dom Jaime de Barros Câmara – sempre o mesmo”
Authors: Besen José Artulino
Published: May 2024

“Dom Jaime de Barros Câmara – sempre o mesmo”
As filhas e filhos excluídos
Authors: Kestering Juventino
Published: May 2024

As filhas e filhos excluídos
A mulher no mundo dos excluídos
Authors: Machado Marta
Published: May 2024

A mulher no mundo dos excluídos
Recanto da esperança
Authors: Ascari Giovani Alberton
Published: May 2024

Recanto da esperança
Os presos, auto-excluídos?
Authors: Pereira Ney Brasil
Published: May 2024

Os presos, auto-excluídos?
Apuntes para una lectura gótica de Boquitas pintadas de Manuel Puig
Authors:   El Colegio de México, México, C. Locke Jessica
Published: May 2024

Partiendo del concepto expresado por Fred Botting, especialista en literatura gótica, de que lo gótico no se restringe ni a un movimento literario en específico ni a un periodo histórico-literario, sino que implica la presencia de ciertas características en la obra en cuestión, analizo los aspectos de la novela Boquitas pintadas de Manuel Puig que, opino, se prestan a una lectura gótica. Entre ellos están la propuesta genérico-estilística de Puig con esta obra, así como las transgresiones de los personajes contra las normas de comportamiento exigidas por la sociedad en la que se mueven, y el cuestionamiento de los parámetros de comportamiento que surge a raíz de dichas transgresiones.
Ficheros desapropiados en Permanente obra negra. La novela inexperta [título provisional], de Vivian Abenshushan et al.
Authors:   Tecnológico de Monterrey, México, Del Castillo Rodríguez Carlos Manuel
Published: May 2024

Vivian Abenshushan et al. utiliza diversos medios, atravesados por la figura del fichero, en Permanente obra negra. La novela inexperta [título provisional] para hacer una crítica de los procesos editoriales. De acuerdo con la escritora, estos suelen carecer de espacios de producción y publicación para la escritura experimental. El actual artículo revisa las estrategias discursivas con las que Abenshushan et al. presenta formas de crear un sentido colectivo a través de decisiones editoriales creativas. La novela analizada rescata la figura del fichero para proponer una manera de compartir saberes y denunciar la explotación de otros en aras de impulsar autorías individuales. Por igual, se enfatiza el rol de la escritura desapropiativa en la generación de prácticas lectoras capaces de ampliar los encuentros a partir del texto.
El horror cotidiano en los cuentos de Amparo Dávila y Shirley Jackson
Authors:   Universidad Nacional  Autónoma de México, México, Gil de la Piedra Claudia
Published: May 2024

Este trabajo propone un análisis comparativo entre algunos cuentos de la escritora mexicana Amparo Dávila (“El huésped” y “Tina Reyes”) y de la estadounidense Shirley Jackson (“Charles” y “El diente”), que pone en evidencia los puntos de encuentro y digresión entre ambas narrativas. La escritura de ambas mujeres se centra en el contexto del espacio doméstico y en la esfera privada, durante las décadas de 1950 y 1960, respectivamente. El objetivo del análisis es explorar, desde el punto de vista de la ficción gótica, el miedo surgido a través de lo cotidiano, apelando a un discurso que se articula a partir de la ruptura de la realidad y la profundización en la construcción de los personajes, quienes manifiestan un horror inefable, el cual es percibido como locura por quienes las rodean. Del mismo modo, se pretende comparar el discurso mexicano y estadounidense, los cuales, a pesar de sus diferencias culturales, coinciden en rasgos de estilo y algunas problemáticas sociales como las que se presentan a continuación.
Nostalgia de Times Square: el Grupo Taller ante la ciudad moderna
Authors:   Tecnológico de Monterrey, México, García Rodríguez Salvador
Published: May 2024

El siguiente artículo abunda sobre la relación de los jóvenes poetas miembros del Grupo Taller con la Ciudad Moderna, con Nueva York como ejemplo de este paradigma. Debido a sus inclinaciones culturales la promoción, entre quienes se encontraban Octavio Paz, Efraín Huerta, Rafael Solana, José Revueltas y Alberto Quintero Álvarez, apuesta por un perfil cosmopolita para relacionarse cultural, política y socialmente con su entorno. Con este posicionamiento como base, el texto rastrea los nexos que el grupo estableció con el mito y la realidad de la Ciudad Moderna, con la industria cinematográfica como telón de fondo.
Evaluate The Role of The Community in Intelligence Gathering on Local Terrorism Activities
Authors: Syukur Genta Pratama , Runturambi Josias Simon
Published: May 2024

Terrorism poses a significant national security threat in Indonesia, exacerbated by the clandestine nature of terrorist networks within society. Harnessing community involvement is pivotal in combating terrorism effectively. This study evaluates the community's role in intelligence gathering pertaining to local terrorist activities. Utilizing qualitative research methods, particularly literature review, the study analyzes data through three key stages: data reduction, presentation, and conclusion drawing. Findings underscore the indispensable contribution of communities in gathering local terrorism intelligence. Unlike conventional channels, communities offer unique insights into terrorist activities inaccessible to law enforcement agencies. However, leveraging community involvement faces challenges and limitations. These include the need for heightened education and training initiatives to enhance community awareness about terrorism. Additionally, fostering trust between communities and law enforcement entities emerges as a critical endeavor. Furthermore, ensuring the safety and protection of individuals reporting terrorism-related information remains imperative for sustained community participation in intelligence-gathering efforts.
Experience of Breastfeeding And Exclusive Breastfeeding For Women With Physical Disabilities: Scoping Review
Authors: Ririn Ririn , Mufdlilah Mufdlilah , Suryaningsih Endang Koni
Published: May 2024

The study aims to investigate the scientific evidence concerning breastfeeding and exclusive breastfeeding experiences among women with physical disabilities. Exclusive breastfeeding entails providing only breast milk to infants from birth to 6 months old, excluding any other food or drinks except medications and vitamins. However, breastfeeding is not halted after exclusive breastfeeding; it continues until the child is two years old. Utilising the scoping review method, the research employed the Population, Concept, and Context (PCC) framework. Six articles meeting the inclusion criteria were identified from a pool of 1,553 articles from PubMed, ScienceDirect, Wiley, and Research Rabbit databases. These articles shed light on the challenges, experiences, barriers, and support systems related to breastfeeding and childcare encountered by women with physical disabilities. The research on breastfeeding experiences among women with physical disabilities reveals both facilitators and barriers. Facilitators include adaptations, peer support, and necessary equipment, while barriers encompass insufficient support, health considerations, and milk production and latching challenges. These findings underscore the importance of tailored support and access to information for women with physical disabilities who aim to breastfeed effectively. Implementing such support mechanisms can contribute to improving breastfeeding rates among this demographic, thus promoting the health and well-being of both mothers and infants while addressing societal attitudes toward disability issues.
Los estudios de Medicina en el Zulia: A 17 decenios de su fundación (1854-2024)
Authors: Ochoa-Barrientos Édixon
Published: May 2024

El inicio definitivo de los estudios médicos en el estado Zulia aconteció el 2 de septiembre de 1854, con la instalación en el Colegio Nacional de Maracaibo del primer curso de Medicina por el doctor Joaquín Esteva Parra, lo que fue posible tras dos intentos fallidos en 1833 y 1846, respectivamente. Sus cursantes egresaban con el título de Bachiller en Medicina. Subsiguientemente, las reformas guzmancistas facultaron a la institución para otorgar los títulos de Licenciado y Doctor en Medicina y otras ciencias, lo cual precipitó la creación, apertura e instalación de la Universidad del Zulia y su Facultad de Ciencias Médicas en 1891, elevando a rango universitario la formación médica. Esta se vio momentáneamente truncada con la clausura de la universidad en 1904 pero, tras dos intentos de restablecer la enseñanza de la Medicina en 1910 y 1915, esta se reanuda con la reapertura de la universidad en 1946 y la reinstalación de su respectiva Facultad en 1948.
Being a Substantial Out of Home Eater: Affecting Factors and Evidence on Daily Nutritional Intake Among University Students
Authors: Mortaş Hande , Varli Semra Navruz , Bilici Saniye
Published: May 2024

In this cross-sectional study, it was aimed to investigate the factors affecting the choice of out of home (OH) eating in university students. A questionnaire containing the sections of age, accommodation and education status was applied to the participants (n = 399). The 24h dietary records were obtained from the participants. The participants were asked to write the locations where they consume the meals. The percentages of substantial OH eaters were 16.7% and 17.7% in males and females, respectively (p>0.05). Staying in dormitory status was found to be increased the probability of being a substantial eater compared to the reference of staying with family (odds ratios were 9.93 for females and 14.79 for males; p<0.05 for both genders). Substantial OH eaters had a higher protein, a higher carbohydrate, and a higher starch intakes than at home eaters (p<0.05 for all nutrients). It has been shown that university students mostly prefer fast food restaurants for OH eating.
Benefits of Modern Imaging Techniques in Medicine
Authors: Bogomolov Danila Andreevich , Antonov Anton Evgenievich , Ilin Aleksandr Igorevich , Beliaeva Margarita Vladimirovna , Bogomolova Tatiana Andreevna
Published: May 2024

Relevance. For more than 100 years, medical practice has used imaging methods to observe pathological changes localized in the human body. The first method was radiography, which became popular among doctors, but later it turned out that high radiation exposure increases the incidence of tumor diseases, which is why standards for permissible radiation doses were developed for patients and radiologists. The introduction of radiocontrast agents also had contraindications that should be taken into account. Ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), and angiography methods have significantly increased the diagnostic capabilities of instrumental methods. The purpose of this review is to analyze the advantages and disadvantages of modern imaging methods in medicine. Methods. To achieve the purpose of the review, a literature search was conducted in Google Scholar and PubMed databases. Results. 1) The main indication for the X-ray method is visualization of bone structures. 2) X-ray contrast methods are optimal for studying hollow organs and blood vessels. 3) The advantage of MRI is the ability to visualize soft tissue well. 4) CT helps to reconstruct the spatial architecture of organs. 5) Ultrasound allows you to observe the condition of the embryo and fetus, as well as internal organs.
Student's Gender Differences in Stress Management Through Communication
Authors: Molchanova Oksana , Yudina Alina , Kocharian Oleksandr , Meloian Anait , Barinova Nataliia
Published: May 2024

The aim of the article is to determine the specifics of optimizing the stress management of boys and girls during the student period through communicative training. The reliable data were obtained through valid and reliable test methods, and a formative experiment was planned and conducted. The results of the formative experiment indicate the moderate effectiveness of the developed communicative training programme for making stress management in student age more effective. Significant gender differences in stress management strategies and consequences of the impact of the training programme were identified. The girls are more focused on the strategy of actively overcoming the problem, planning a solution to the problem, and looking for social support. The boys are more focused on self-control, distancing, positive reassessment of the situation. Indicators of psychological well-being are higher among the boys compared to the girls. The training programme proved effective for the girls in building stress resistance, self-control, acceptance of responsibility, and psychological well-being. For boys, the most effective formative influence was based on self-control, search for social support, and the escape coping strategy. The study results can be used to optimize psychological assistance and the educational process at the student age.
Construcción de un plan de cultura sexual para escolares peruanos
Authors: Remuzgo-Huamán Sara Emilia , Palomino-Remuzgo Alessandra Nikole
Published: May 2024

El artículo presenta los resultados de la investigación realizada a un grupo poblacional muy sensible, de gran importancia y trascendencia: los y las adolescentes, talento humano que se sumará al crecimiento y desarrollo de una nación. El objetivo es robustecer la edificación de un plan de vida respecto al progreso de una sexualidad sana en escolares del nivel secundario en 07 casas de estudio de un distrito popular de Lima metropolitana en el 2019. La muestra fue 174 estudiantes (dos religiosos, siete directores y siete docentes). Los resultados indicaron que el 70% conocen sobre temas ligados a su sexualidad, pero cuyos indicadores nacionales reflejan otra cosa, como las carencias afectivas, ya que desconocen la dimensión y la valía de una verdadera relación genital, así como tampoco reconocen el papel de la familia en la sociedad. Aspecto corroborado por los involucrados en el estudio, manifestando su preocupación por este nuevo grupo humano. Se concluye que el plan de vida es satisfactorio, si se edifica una sana educación sexual con sabiduría y una activa participación de los stakeholders (familia, escuela, medios de comunicación, sociedad civil, Estado, Iglesia y ciudadanos). Siendo propicia la propuesta de proyecto de vida bajo la mirada científica- holística.
Evaluación de la calidad del agua: Caso río Copueno en Ecuador
Authors: Chacón-Vélez Katherine Elizabeth , Haro-Barroso Camilo Pavel , Carrera-Beltrán Lourdes Cumandá
Published: May 2024

El presente estudio tuvo como objetivo evaluar la calidad biológica del río Copueno ubicado en Ecuador, empleando como método científico macroinvertebrados bentónicos como bioindicadores. Los especímenes recolectados se analizaron en el Laboratorio del Gobierno Provincial de Morona Santiago, donde se aplicaron dos Índices biológicos: Biological Monitoring Working Party (BMWP/Col) y Ephemeropteras, Plecopteras y Trichopteras (EPT), con la finalidad de determinar la calidad del agua, asignándose valores a los diferentes organismos de acuerdo a su nivel de tolerancia a la contaminación, que oscilaron entre uno 01 (los más tolerantes) y diez 10 (los más sensibles). Entre los resultados obtenidos tenemos que, de un total de 3122 especímenes recolectados, (1391 en verano y 1731 en invierno), la calidad del agua en temporada seca según el BMWP/Col es buena, y aceptable en la temporada húmeda, mientras que, de acuerdo al EPT, la calidad es REGULAR durante las dos estaciones. En conclusión, se establece que la calidad del agua decrece a medida que se acerca al casco urbano, por ello la importancia de la conservación de los cuerpos hídricos es primordial en la zona de estudio.
Reflexiones sobre las políticas públicas en la salud: Investigación, participación ciudadana y gestión
Authors: Bustos-Viviescas Brian Johan , García Yerena Carlos Enrique , Baena-Marín Mateo , Villamizar Navarro Amalia , García Galviz John Alexander
Published: May 2024

Introducción: Las políticas públicas están estrechamente relacionadas con la salud pública. Sin embargo, esta relación es desconocida por parte de muchos profesionales en el área de la salud. Objetivo: El propósito de este artículo es realizar una reflexión crítica sobre las políticas públicas en la salud, desde el panorama de la investigación, la participación ciudadana y la gestión. Resultados: Posterior a la consulta de las fuentes científicas de referencia se describieron como tópicos: a) las características fundamentales de las políticas públicas, b) el marco de referencia de las políticas públicas, c) la salud como derecho universal, d) las funciones esenciales de la salud pública, e) las políticas de salud pública y principales oportunidades con relación al enfoque de salud y f) los desafíos pendientes de la salud pública en América Latina. Conclusión: Se evidencia que las políticas públicas cumplen un factor determinante para la mejora en la salud de las poblaciones. No obstante, para lograr dicho fin se requiere de la participación de diferentes actores sociales para que se beneficie toda la población y no solamente un sector en particular.
Capsule Attention Based Detection of Contraband in X-Ray Images
Authors:   School of Electrical Engineering and Automation, Henan Polytechnic University, Jiaozuo 454000, China & Henan Key Laboratory of Intelligent Detection and Control of Coal Mine Equipment, Jiaozuo 454000, China, Zhiming YAN , Xinwei LI ,   School of Electrical Engineering and Automation, Henan Polytechnic University, Jiaozuo 454000, China & Henan Key Laboratory of Intelligent Detection and Control of Coal Mine Equipment, Jiaozuo 454000, China, Yi YANG ,   School of Electrical Engineering and Automation, Henan Polytechnic University, Jiaozuo 454000, China & Henan Key Laboratory of Intelligent Detection and Control of Coal Mine Equipment, Jiaozuo 454000, China
Published: May 2024

Aiming at the problem of low detection accuracy caused by the different postures, different sizes, complex backgrounds and overlapping occlusions of contraband in the security checking process, a Matrix capsule network based on attention mechanism (MCAM) is designed by introducing attention mechanism into the capsule network. Firstly, a multi-feature-extraction (MFE) module is designed to solve the difficulty of detecting contraband with different sizes and complex backgrounds; then the Conv2d with Attention for ConvCap (CACC) is constructed in the convolutional layer of the capsule, and the weight information is computed in the channel dimensions of the feature map to give the contraband regions higher coefficients to enhance the contraband detection ability when the poses are different and the occlusion is severe; finally, a new capsule detection layer is designed by utilizing the pose matrix of the capsule to give full play to the detection ability of the matrix capsule network. The mAPs of the proposed model on SIXray, SIXray10, and SIXray100 are 85.10%, 64.05%, and 53.67%, respectively, which are 42.79%, 19.73%, and 9.41% higher than those of the original network, higher than those of the current mainstream detection networks, and the number of parameters of the network and the amount of computation are also lower.
Control the Speed of Separately Excited Dc Motor Using Sliding Mode Controller
Authors:   Department of Mechatronics Engineering, Federal University Otuoke, Bayelsa State, Nigeria., Ujam Chinedu James , Adeniyi D. Adebayo ,   Department of Electrical and Electronic Engineering, Federal University, Otuoke, Bayelsa State, Nigeria.
Published: May 2024

This study looks into how a Sliding Mode Controller (SMC) can be used to control a Separately Excited DC Motor's (SEDCM) speed. The SMC is utilized to improve the system's resilience to unknowns and disruptions, guaranteeing accurate control under changing operational circumstances. Extensive simulations and experimental settings confirm the suggested control technique, which shows improved performance in terms of stability, disturbance rejection, and speed tracking. The results further the development of DC motor control techniques, especially in situations where robustness and precision are crucial.
Enhancing Domestic Wastewater Treatment: A Study on the Efficacy of Tiered Filtration and a Combined Photocatalytic Ozonation Methods
Authors:   Metallurgy Engineering Departement, Politeknik Negeri Batam, Kota Batam, Indonesia, Gemala Mega , Saputra Roni ,   Environmental Health Department, Universitas Ibnu Sina, Kota Batam, Indonesia, Fyona Annisa ,   Mechanical Engineering Departement, Politeknik Negeri Batam, Kota Batam, Indonesia, Wijayanti Ita ,   Mechanical Engineering Departement, Politeknik Negeri Batam, Kota Batam, Indonesia, Restu Fedia ,   Mechanical Engineering Departement, Politeknik Negeri Batam, Kota Batam, Indonesia, Irawati Ice ,   Occupational Health and Safety Departement, Universitas Ibnu Sina, Kota Batam, Indonesia, Aryswan Adhe ,   Mechanical Engineering Departement, Politeknik Negeri Batam, Kota Batam, Indonesia, Oktarizal Hengky ,   Environmental Health Department, Universitas Ibnu Sina, Kota Batam, Indonesia
Published: May 2024

This study aimed to construct an optimized reactor using photocatalytic ozonation, and its effectiveness was determined using PermenLHK No. 86/2016. The Tanjung Uma housing estate in Batam city was selected as the study sample site for domestic wastewater because of its role as a significant water body that receives liquid waste from a majority of activities across the city. The experiment employed a quantitative research approach and a true experimental approach, testing variables (catalyst weight, UV irradiation time, and ozonation duration) in a laboratory setting (25°C and 40-70% Humidity). The study found that the optimized parameter (a combination of 2 h of irradiation, with 2 g of TiO2 along with 5 min of ozonation) resulted in a significant difference in water quality parameters compared to before treatment with 92% effectivity. It can be concluded that this Reactor prototype was highly successful in reducing environmental impacts based on its effectiveness
Sommer, Doris. The Work of Art in the World: Civic Agency and Public Humanities (Durham, NC: Duke University Press, 2014)
Authors:   Phd Student , UIZ University Agadir, Morocco, Idyassine Mohamed
Published: May 2024

Doris Sommer's Book The Work of Art in the World: Civic Agency and Public Humanities must be received as vivid recollections of anecdotal and yielding civic interventions. Most of these celebrated creative social interventions relate either to confident "high-ranking" political leaders or weird grassroots artists in some particular socioeconomic contexts already in paralysis.no doubt, such models of civic initiatives cannot be transposed to other communities; therefore, it is easy to reject Sommer's propositions as over-optimistic and operationally inapplicable. It is also acceptable here to restate the reactions of the Duke Press editors who told Doris Sommer right at the onset that this book "is too much theory" and "no one wants to read theory".1
Comité de Cáncer. Detección de cáncer de páncreas en pacientes con diabetes mellitus
Authors: Maraschio Martín Atilio , Buso Carlos Javier , Croxato María Eugenia , Maltagliatti Daniela
Published: May 2024

Introducción: La diabetes mellitus tipo 2 (DM2) y el cáncer son entidades de alta prevalencia que contribuyen de manera independiente a gran parte de la morbimortalidad mundial. El metabolismo alterado de los hidratos de carbono está presente en aproximadamente 3/4 de los casos del adenocarcinoma ductal pancreático que, además, es el responsable de aproximadamente el 90% de todos los casos de cáncer de páncreas.
Considerar a la hiperglucemia como un biomarcador temprano y un factor de riesgo para este tipo tumoral en personas con DM de nueva aparición (o progresión rápida de la hiperglucemia con necesidad temprana de insulina) y en mayores de 60 años acompañada de pérdida de peso (>4 kg) debe ser un incentivo para una investigación rápida y detallada para excluir el adenocarcinoma ductal pancreático dado que el diagnóstico temprano mejora el pronóstico y la sobrevida de esta entidad de baja frecuencia, pero alta letalidad.
Objetivos: General: destacar la relevancia de la DM en la aparición, progresión y pronóstico de la patología oncológica. Específicos: resaltar la importancia de la DM como marcador de enfermedad tumoral subyacente; aportar aspectos clínicos relacionados con el metabolismo de los hidratos de carbono que favorezcan un diagnóstico temprano de cáncer de páncreas.
Materiales y métodos: se llevó a cabo una revisión bibliográfica y actualización sobre el tema, además de la experiencia aportada por un estudio retrospectivo sobre el tema realizado por este Comité. Se realizó una búsqueda bibliográfica de los últimos 5 años en los buscadores PubMed, ScienceDirect, SciELO y Wiley de artículos en inglés y en español, bajo el motor de búsqueda “pancreatic cancer and diabetes”. En total se seleccionaron 542 artículos, por su relevancia y calidad, y de estos se usaron 23. También se incluyeron artículos de alta relevancia, con una antigüedad de más de 5 años.
Hallazgos: la DM es un marcador del riesgo temprano y un factor de riesgo para el desarrollo de cáncer de páncreas.
Conclusiones: la abundante evidencia existente en cuanto a la relación entre la patología oncológica, la obesidad y la DM obliga a repensar la enfermedad oncológica por sus aspectos fisiopatológicos, y vincular su etiología con la enfermedad metabólica y la inflamación de bajo grado.
Comité de Innovación. Uso de los sistemas de infusión continua de insulina en personas con DM1
Authors: Carnero Rodrigo , Saleme Antonio , Lequi Lorena , Dain Alejandro , Soto Campos Florencia , Sosa Lucas , Flores Adriana , Kabakian Laura
Published: May 2024

El uso de bombas de bombas de insulina ha permitido mejorar la calidad de la atención de los pacientes con diabetes mellitus 1 (DM1), en términos de optimizar la hemoglobina A1c, y reducir la frecuencia y gravedad de las hipoglucemias. Las continuas innovaciones en la tecnología de inyección subcutánea continua de insulina (ISCI) condujeron al desarrollo de una amplia gama de productos, desde dispositivos desechables (tipo parche) hasta sofisticadas bombas de insulina con funciones avanzadas para automatizar la dosificación de insulina. Estos avances mejoraron la calidad de vida de las personas con DM y disminuyeron la carga de la enfermedad. En estas recomendaciones resumimos las principales evidencias para la indicación de los sistema de ICSI.
Civic engagement penyandang disabilitas dalam memperjuangkan hak atas pekerjaan (studi pada induk disabilitas Purworejo)
Authors: Mulia Ibnata Bikry , Yuliandari Erna , Hartanto Rima Vien Permata
Published: May 2024

Work is self-actualization by channeling and developing abilities to be more productive to achieve a prosperous life. Work is one of the rights that every person, including people with disabilities, is born with, and must be fulfilled and respected. However, in its implementation, there is a lack of attention from the authorities related to employment issues and legal guarantees. This research analyzes the civic engagement of people with disabilities through Induk Disabilitas Purworejo, in which the majority of members are people with physical disabilities fighting for their right to work. This research also analyzes the supporting and inhibiting factors for the success of civic engagement. The research method is qualitative with purposive sampling. Research data were gathered through observation, interviews, and document studies. The result of the discussion is that the civic engagement of people with disabilities through Induk Disabilitas Purworejo in fighting for the right to work is actualized through activity programmes such as advocacy, working with local agencies and opening small trainings at regular meetings in accordance with the components and indicators of civic engagement. In addition, there are supporting factors that are analyzed such as motivation and a sense of responsibility and skills from people with disabilities supported by the role of family, Induk Disabilitas Purworejo assistants, wheelchair aids, and civic cohesion. There are inhibiting factors that affect civic engagement, namely the lack of attention from the Regent regarding the guarantee of legal rights for people with disabilities and lack of accessibility during the implementation of activity programmes.
Literatur Review: Strategi Blended Learning dalam Meningkatkan Mutu Pembelajaran di Sekolah Menengah Atas (Studi Kasus pada SMA N 9 Binsus Manado)
Authors: Rotty Viktory N. J. , Rambitan Bella F. , Sumual Syerri Y. , Sadsuitubun Marisca A. B. , Wakur Neiles
Published: May 2024

The purpose of this study is to find out how the Blended Learning strategy in improving the quality of learning at SMA N 9 Binsus Manado. This research uses the method of literature study. The results showed that the presence of the industrial revolution era 4.0 is a challenge for the field of education. Entering the era of the industrial revolution 4.0, educators (teachers) at all levels of formal education, including junior and senior high schools, are required to master the ability or expertise to adapt to new technology. This is intended to improve the quality of existing learning by utilizing growing technology. Blended Learning is one of the concepts of education 4.0 that can be used as a form of educator strategy in improving the quality of learning in the era of the industrial revolution 4.0, especially in fulfilling mastery of technology. Several blended learning models that have currently been implemented by SMA N Binsus Manado in order to improve the quality of learning include Google Classroom; Social Media Whatsapp, Facebook and Telegram; Moodle; Zoom Meeting; Edmodo and Microsoft Education Office 365.
Pengaruh intensitas penggunaan aplikasi shopee terhadap perilaku konsumtif ditinjau dari persfektif Pancasila
Authors: Yani Dwi Fitri , Salam M. , Candra Alif Aditya
Published: May 2024

The development of globalization in the previously traditional economic sector has shifted towards digitalization, affecting the high use of the Shopee application by Jambi University PPKn students. This phenomenon has resulted in consumptive behavior that is not in harmony with the values of Pancasila. This study aims to determine the impact of the intensity of using the Shopee application on student consumptive behavior, by considering the Pancasila perspective. A quantitative approach was used in this study through survey methods, involving 39 respondents. Data analysis using SPSS Version 26 shows that the intensity of using the Shopee application significantly affects the consumptive behavior of Jambi University PPKn students, with a p-value of < alpha (0.000 < 0.05). The effect reached 54.3%, while other influencing factors were not studied in this study.
Force-Time Characteristics in Collegiate Weightlifters Using Two Isometric Pull Protocols
Authors: Rochau Kyle , Gawel Wesley , Burton Jarrod , Layne Andrew , Hornsby William , Stone Michael
Published: May 2024

The isometric mid-thigh pull (IMTP) is commonly used to measure isometric strength of characteristics of weightlifters. The isometric pull from the start position (IPSP) has not been studied as much as the IMTP but may potentially be a viable option for a weightlifting monitoring program. This study aims to compare isometric force-time characteristics from both the IMTP and IPSP to weightlifting competition performance. Collegiate weightlifters’ performances were compared to isometric peak force (IPF), rate of force development (RFD), and allometrically scaled peak force (IPFa) of both isometric testing protocols by a Pearson’s Correlation Coefficient. Strong correlations between weightlifting performance and force-time characteristics for both protocols were found with IPSP having slightly higher correlations. This suggests that both isometric testing protocols are viable tools for predicting weightlifting performance. It may be useful to include both protocols in a weightlifting monitoring program.