bluuebunny/crossref_metadata_2025 huggingface dataset:
Neuromodulation by nanozymes and ultrasound during Alzheimer’s disease management
Authors: Karthika Viswanathan , Badrinathan Sridharan  , Nam Ji Won , Kim Daehun , Gyun Lim Hae
Published: March 2024

Alzheimer’s disease (AD) is a neurodegenerative disorder with complex pathogenesis and effective clinical treatment strategies for this disease remain elusive. Interestingly, nanomedicines are under extensive investigation for AD management. Currently, existing redox molecules show highly bioactive property but suffer from instability and high production costs, limiting clinical application for neurological diseases. Compared with natural enzymes, artificial enzymes show high stability, long-lasting catalytic activity, and versatile enzyme-like properties. Further, the selectivity and performance of artificial enzymes can be modulated for neuroinflammation treatments through external stimuli. In this review, we focus on the latest developments of metal, metal oxide, carbon-based and polymer based nanozymes and their catalytic mechanisms. Recent developments in nanozymes for diagnosing and treating AD are emphasized, especially focusing on their potential to regulate pathogenic factors and target sites. Various applications of nanozymes with different stimuli-responsive features were discussed, particularly focusing on nanozymes for treating oxidative stress-related neurological diseases. Noninvasiveness and focused application to deep body regions makes ultrasound (US) an attractive trigger mechanism for nanomedicine. Since a complete cure for AD remains distant, this review outlines the potential of US responsive nanozymes to develop future therapeutic approaches for this chronic neurodegenerative disease and its emergence in AD management.

Graphical Abstract
Focused ultrasound-mediated blood–brain barrier opening is safe and feasible with moderately hypofractionated radiotherapy for brainstem diffuse midline glioma
Authors: Tazhibi Masih , McQuillan Nicholas , Wei Hong-Jian , Gallitto Matthew , Bendau Ethan , Webster Carrion Andrea , Berg Xander , Kokossis Danae , Zhang Xu , Zhang Zhiguo , Jan Chia-Ing , Mintz Akiva , Gartrell Robyn D. , Syed Hasan R. , Fonseca Adriana , Pavisic Jovana , Szalontay Luca , Konofagou Elisa E. , Zacharoulis Stergios , Wu Cheng-Chia
Published: March 2024

Background

Diffuse midline glioma (DMG) is a pediatric tumor with dismal prognosis. Systemic strategies have been unsuccessful and radiotherapy (RT) remains the standard-of-care. A central impediment to treatment is the blood–brain barrier (BBB), which precludes drug delivery to the central nervous system (CNS). Focused ultrasound (FUS) with microbubbles can transiently and non-invasively disrupt the BBB to enhance drug delivery. This study aimed to determine the feasibility of brainstem FUS in combination with clinical doses of RT. We hypothesized that FUS-mediated BBB-opening (BBBO) is safe and feasible with 39 Gy RT.

Methods

To establish a safety timeline, we administered FUS to the brainstem of non-tumor bearing mice concurrent with or adjuvant to RT; our findings were validated in a syngeneic brainstem murine model of DMG receiving repeated sonication concurrent with RT. The brainstems of male B6 (Cg)-Tyrc-2J/J albino mice were intracranially injected with mouse DMG cells (PDGFB+, H3.3K27M, p53−/−). A clinical RT dose of 39 Gy in 13 fractions (39 Gy/13fx) was delivered using the Small Animal Radiation Research Platform (SARRP) or XRAD-320 irradiator. FUS was administered via a 0.5 MHz transducer, with BBBO and tumor volume monitored by magnetic resonance imaging (MRI).

Results

FUS-mediated BBBO did not affect cardiorespiratory rate, motor function, or tissue integrity in non-tumor bearing mice receiving RT. Tumor-bearing mice tolerated repeated brainstem BBBO concurrent with RT. 39 Gy/13fx offered local control, though disease progression occurred 3–4 weeks post-RT.

Conclusion

Repeated FUS-mediated BBBO is safe and feasible concurrent with RT. In our syngeneic DMG murine model, progression occurs, serving as an ideal model for future combination testing with RT and FUS-mediated drug delivery.
Real world clinical experience using daily intelligence-assisted online adaptive radiotherapy for head and neck cancer
Authors: Blumenfeld Philip , Arbit Eduard , Den Robert , Salhab Ayman , Falick Michaeli Tal , Wygoda Marc , Hillman Yair , Pfeffer Raphael M. , Fang Marcel , Misrati Yael , Weizman Noam , Feldman Jon , Popovtzer Aron
Published: March 2024

Background

Adaptive radiation therapy (ART) offers a dynamic approach to address structural and spatial changes that occur during radiotherapy (RT) for locally advanced head and neck cancers. The integration of daily ART with Cone-Beam CT (CBCT) imaging presents a solution to enhance the therapeutic ratio by addressing inter-fractional changes.

Methods

We evaluated the initial clinical experience of daily ART for patients with head and neck cancer using an online adaptive platform with intelligence-assisted workflows on daily CBCT. Treatment included auto-contour and structure deformation of Organs at Risk (OARs) and target structures, with adjustments by the treating physician. Two plans were generated: one based on the initial CT simulation with the edited structures (scheduled) and a re-optimized plan (adaptive). Both plans were evaluated and the superior one approved and delivered. Clinical and dosimetric outcomes were reviewed.

Results

Twenty two patients with head and neck cancers (7 Nasopharynx, 6 Oropharynx, 1 oral cavity, 8 larynx) stages I-IVA were treated with daily ART. 770 adaptive and scheduled radiotherapy plans were generated. 703 (91.3%) adaptive plans were chosen. Median time to deliver ART was 20 minutes (range: 18-23). Adaptive compared to scheduled plans demonstrated improved mean V95 values for the PTV70, PTV59.5, and PTV56 by 1.2%, 7.2%, and 6.0% respectively and a mean 1.4% lower maximum dose in PTV70. Fourteen of 17 OARs demonstrated improved dosimetry with adaptation, with select OARs reaching statistical significance. At a median follow up of 14.1 months, local control was 95.5%, two patients developed metastatic disease and four patients died. 9.1% of patients had acute grade 3 dysphagia and 13.6% had grade 2 chronic xerostomia.

Discussion

These findings provide real world evidence of the feasibility and dosimetric benefit of incorporating daily ART on CBCT in the treatment of head and neck cancer. Prospective study is needed to determine if these dosimetric improvements translate into improved outcomes.
FNDC5/irisin ameliorates bone loss of type 1 diabetes by suppressing endoplasmic reticulum stress‑mediated ferroptosis
Authors: Dong Qianqian , Han Ziqi , Gao Mingdong , Tian Limin
Published: March 2024

Background

Ferroptosis is known to play a crucial role in diabetic osteopathy. However, key genes and molecular mechanisms remain largely unclear. This study aimed to identify a crucial ferroptosis-related differentially expressed gene (FR-DEG) in diabetic osteopathy and investigate its potential mechanism.

Methods

We identified fibronectin type III domain-containing protein 5 (FNDC5)/irisin as an essential FR-DEG in diabetic osteopathy using the Ferroptosis Database (FerrDb) and GSE189112 dataset. Initially, a diabetic mouse model was induced by intraperitoneal injection of streptozotocin (STZ), followed by intraperitoneal injection of irisin. MC3T3-E1 cells treated with high glucose (HG) were used as an in vitro model. FNDC5 overexpression plasmid was used to explore underlying mechanisms in vitro experiments. Femurs were collected for micro-CT scan, histomorphometry, and immunohistochemical analysis. Peripheral serum was collected for ELISA analysis. Cell viability was assessed using a CCK-8 kit. The levels of glutathione (GSH), malondialdehyde (MDA), iron, reactive oxygen species (ROS), and lipid ROS were detected by the corresponding kits. Mitochondria ultrastructure was observed through transmission electron microscopy (TEM). Finally, mRNA and protein expressions were examined by quantitative real‐time PCR (qRT‐PCR) and western blot analysis.

Results

The expression of FNDC5 was found to be significantly decreased in both in vivo and in vitro models. Treatment with irisin significantly suppressed ferroptosis and improved bone loss. This was demonstrated by reduced lipid peroxidation and iron overload, increased antioxidant capability, as well as the inhibition of the ferroptosis pathway in bone tissues. Furthermore, in vitro studies demonstrated that FNDC5 overexpression significantly improved HG-induced ferroptosis and promoted osteogenesis. Mechanistic investigations revealed that FNDC5 overexpression mitigated ferroptosis in osteoblasts by inhibiting the eukaryotic initiation factor 2 alpha (eIF2α)/activated transcription factor 4 (ATF4)/C/EBP-homologous protein (CHOP) pathway.

Conclusions

Collectively, our study uncovered the important role of FNDC5/irisin in regulating ferroptosis of diabetic osteopathy, which might be a potential therapeutic target.
Development and validation of a prognostic model for predicting post-discharge mortality risk in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI)
Authors: Zhang Lingling , Liu Zhican , Zhu Yunlong , Wu Mingxin , Huang Haobo , Yang Wenbin , Peng Ke , Zeng Jianping
Published: March 2024

Background

Accurately predicting post-discharge mortality risk in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) remains a complex and critical challenge. The primary objective of this study was to develop and validate a robust risk prediction model to assess the 12-month and 24-month mortality risk in STEMI patients after hospital discharge.

Methods

A retrospective study was conducted on 664 STEMI patients who underwent PPCI at Xiangtan Central Hospital Chest Pain Center between 2020 and 2022. The dataset was randomly divided into a training cohort (n = 464) and a validation cohort (n = 200) using a 7:3 ratio. The primary outcome was all-cause mortality following hospital discharge. The least absolute shrinkage and selection operator (LASSO) regression model was employed to identify the optimal predictive variables. Based on these variables, a regression model was constructed to determine the significant predictors of mortality. The performance of the model was evaluated using receiver operating characteristic (ROC) curve analysis and decision curve analysis (DCA).

Results

The prognostic model was developed based on the LASSO regression results and further validated using the independent validation cohort. LASSO regression identified five important predictors: age, Killip classification, B-type natriuretic peptide precursor (NTpro-BNP), left ventricular ejection fraction (LVEF), and the usage of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers/angiotensin receptor-neprilysin inhibitors (ACEI/ARB/ARNI). The Harrell's concordance index (C-index) for the training and validation cohorts were 0.863 (95% CI: 0.792–0.934) and 0.888 (95% CI: 0.821–0.955), respectively. The area under the curve (AUC) for the training cohort at 12 months and 24 months was 0.785 (95% CI: 0.771–0.948) and 0.812 (95% CI: 0.772–0.940), respectively, while the corresponding values for the validation cohort were 0.864 (95% CI: 0.604–0.965) and 0.845 (95% CI: 0.705–0.951). These results confirm the stability and predictive accuracy of our model, demonstrating its reliable discriminative ability for post-discharge all-cause mortality risk. DCA analysis exhibited favorable net benefit of the nomogram.

Conclusion

The developed nomogram shows potential as a tool for predicting post-discharge mortality in STEMI patients undergoing PPCI. However, its full utility awaits confirmation through broader external and temporal validation.
Antiplasmodial potential of phytochemicals from Citrus aurantifolia peels: a comprehensive in vitro and in silico study
Authors: Elmaidomy Abeer H. , Abdelmohsen Usama Ramadan , Sayed Ahmed M. , Altemani Faisal H. , Algehainy Naseh A. , Soost Denisa , Paululat Thomas , Bringmann Gerhard , Mohamed Esraa M.
Published: March 2024

Phytochemical investigation of Key lime (Citrus aurantifolia L., F. Rutaceae) peels afforded six metabolites, known as methyl isolimonate acetate (1), limonin (2), luteolin (3), 3ˋ-hydroxygenkwanin (4), myricetin (5), and europetin (6). The structures of the isolated compounds were assigned by 1D NMR. In the case of limonin (2), further 1- and 2D NMR experiments were done to further confirm the structure of this most active metabolite. The antiplasmodial properties of the obtained compounds against the pathogenic NF54 strain of Plasmodium falciparum were assessed in vitro. According to antiplasmodial screening, only limonin (2), luteolin (3), and myricetin (5) were effective (IC50 values of 0.2, 3.4, and 5.9 µM, respectively). We explored the antiplasmodial potential of phytochemicals from C. aurantifolia peels using a stepwise in silico-based analysis. We first identified the unique proteins of P. falciparum that have no homolog in the human proteome, and then performed inverse docking, ΔGBinding calculation, and molecular dynamics simulation to predict the binding affinity and stability of the isolated compounds with these proteins. We found that limonin (2), luteolin (3), and myricetin (5) could interact with 20S a proteasome, choline kinase, and phosphocholine cytidylyltransferase, respectively, which are important enzymes for the survival and growth of the parasite. According to our findings, phytochemicals from C. aurantifolia peels can be considered as potential leads for the development of new safe and effective antiplasmodial agents.
Determination of indoxyl sulfate by spectrofluorimetric method in human plasma through extraction with deep eutectic solvent
Authors: Shafiee Samira , Dastmalchi Siavoush , Gharekhani Afshin , Shayanfar Ali
Published: March 2024

A rapid and efficient analytical method was established to quantify indoxyl sulfate (IS) in plasma through extraction technique with a deep eutectic solvent (DES) and spectrofluorimetric method. DES (choline chloride: urea) was mixed with plasma samples for the extraction of IS, followed by the addition of dipotassium hydrogen phosphate (K2HPO4) solution to form an aqueous two-phase system. The fluorescence intensity of IS which was first extracted to the DES-rich-phase and then back-extracted into the salt-rich-phase, was measured by spectrofluorimetric method. Some key factors such as pH, centrifugation speed and time, the volume ratio of DES/salt, and salt concentration were optimized. Under the optimized conditions, the suggested method had a dynamic range between 20 and 160 µg/mL with a coefficient of determination (R2) of 0.99. Precision (relative standard deviation) was less than 15% and accuracy (% relative recovery) was ± 15% at the nominal concentration level. In addition, results showed that IS levels in real samples were higher than 40 µg/mL which was compatible with reported IS levels in end-stage renal disease (ESRD) patients. Overall, all the results reflect the fact that the presented analytical method can potentially be used for the determination of IS in real plasma samples.
Management of cardiogenic shock: a narrative review
Authors: Laghlam Driss , Benghanem Sarah , Ortuno Sofia , Bouabdallaoui Nadia , Manzo-Silberman Stephane , Hamzaoui Olfa , Aissaoui Nadia
Published: March 2024

Cardiogenic shock (CS) is characterized by low cardiac output and sustained tissue hypoperfusion that may result in end-organ dysfunction and death. CS is associated with high short-term mortality, and its management remains challenging despite recent advances in therapeutic options. Timely diagnosis and multidisciplinary team-based management have demonstrated favourable effects on outcomes. We aimed to review evidence-based practices for managing patients with ischemic and non-ischemic CS, detailing the multi-organ supports needed in this critically ill patient population.
Investigation of safety and efficacy of febantel and fenbendazole in fish and exposure assessment
Authors: Kim Min Ji , Kim Ji Young , Shin Dong Woo , Kim Hyun-Kyung
Published: March 2024

Fish are susceptible to blood-sucking parasite infections, which cause severe anemia, dyspnea, and ultimately death. However, veterinary drugs available for fish to treat such infectious diseases are lacking; thus, livestock drugs have been repurposed as aquatic animal drugs. Febantel (FBT) and fenbendazole (FBZ) are representative antiparasitic agents for livestock such as cattle, swine, and poultry, and are considered suitable as aquatic animal drugs. Therefore, we investigated the safety and efficacy of FBT and FBZ in fish and performed a risk assessment to determine the maximum residue limit in fish. Most studies indicate that FBT is rapidly converted to FBZ, which is metabolized to oxfendazole and oxfendazole sulfone. FBZ was frequently detectable in the plasma and tissues (e.g., muscle, skin, and the liver) in significant quantities than other metabolites. We regarded the liver as the target organ because reversible hepatocytic changes were observed in fish after administration of 100 mg/kg FBT for 9 days. No toxicological effects, such as increased mortality or decreased appetite, were observed when the fish were administered 50 mg/kg FBT for 3 days. The efficacy of the drugs was verified in various parasites, including H. heterocerca, H. okamotoi or Z. japonica, and M. seriolae, as causative agents of beko disease through laboratory and field trials. Although toxicity studies on FBZ in fish are limited, its safety has been demonstrated from toxicity studies in a wide range of animal models. The risk from using FBT and FBZ was negligible for human health because the ratio of the estimates of dietary exposure and acceptable daily intake was 78.4%.
A narrative review of non-invasive brain stimulation techniques in neuropsychiatric disorders: current applications and future directions
Authors: Aderinto Nicholas , Olatunji Gbolahan , Muili Abdulbasit , Kokori Emmanuel , Edun Mariam , Akinmoju Olumide , Yusuf Ismaila , Ojo Deborah
Published: March 2024

Background

Neuropsychiatric disorders significantly burden individuals and society, necessitating the exploration of innovative treatment approaches. Non-invasive brain stimulation techniques have emerged as promising interventions for these disorders, offering potential therapeutic benefits with minimal side effects. This narrative review provides a comprehensive overview of non-invasive brain stimulation techniques' current applications and future directions in managing neuropsychiatric disorders.

Methods

A thorough search of relevant literature was conducted to identify studies investigating non-invasive brain stimulation techniques in neuropsychiatric disorders. The selected studies were critically reviewed, and their findings were synthesised to provide a comprehensive overview of the current state of knowledge in the field.

Results

The review highlights the current applications of non-invasive brain stimulation techniques in neuropsychiatric disorders, including major depressive disorder, Parkinson's disease, schizophrenia, insomnia, and cognitive impairments. It presents evidence supporting the efficacy of these techniques in modulating brain activity, alleviating symptoms, and enhancing cognitive functions. Furthermore, the review addresses challenges such as interindividual variability, optimal target site selection, and standardisation of protocols. It also discusses potential future directions, including exploring novel target sites, personalised stimulation protocols, integrating with other treatment modalities, and identifying biomarkers for treatment response.

Conclusion

Non-invasive brain stimulation techniques offer promising avenues for managing neuropsychiatric disorders. Further research is necessary to optimise stimulation protocols, establish standardised guidelines, and identify biomarkers for treatment response. The findings underscore the potential of non-invasive brain stimulation techniques as valuable additions to the armamentarium of neuropsychiatric treatments.
Developing a cultural-based realistic mathematics education learning video on congruence and similarity
Authors: Mahmudah Faisa Nirbita , Rusmining Rusmining
Published: March 2024

The Covid-19 pandemic has made learning activities carried out online so that many students have difficulty understanding the material, so interesting learning media are needed with flexible access. This study aims to develop a learning video with a culture-based RME approach on congruence and similarity materials and to determine the validity and practicality of the product. This type of research is development research with the ADDIE research model. The subjects of this study were students of class IX A MTs Negeri 9 Bantul. The data collection methods are interviews and questionnaires. The data analysis step is carried out by calculating and analyzing the results of the validity and practicality tests. The results of the product validity test obtained very valid criteria with an average value of 4.75 by material experts and 4.82 by media experts. At the same time, the practicality test got a percentage of 91.82% with very practical criteria in small class trials and a percentage of 82.67% with very practical criteria in large class trials. Based on these results, the learning video can be declared very valid and very practical to use in learning.
Improving 8th-grade students’ problem-solving skills and self-efficacy in probability using discovery learning
Authors: Hartiana Wa Ode , Andriyani Andriyani
Published: March 2024

This study aims to improve students' problem-solving skills and self-efficacy with the discovery learning model on the probability material for grade of VIII SMP. This type of research is classroom action research which is carried out in two cycles, with each cycle consisting of planning, action, observation and reflection stages. The subjects of this research were 32 students from grades of VIII. Data collection was used using questionnaires, observation and test techniques. Research data were analyzed through data reduction, data presentation and conclusion. Based on the study's results, it is known that implementing the discovery learning model can improve students' problem-solving skills and self-efficacy. This can be seen from the increase in the average score of students in the first cycle, which is 71 to 76.66 in the second cycle. The percentage of completeness in the first cycle also increased from 78% to 90% in the second cycle. This increase was also accompanied by an improved student self-efficacy from the percentage of 43.75% of students with high minimum criteria in cycle 1 to 66% in cycle II.
The future of education related to SDG 16 (peace, ‎justice and strong institutions): A position paper
Authors: Kowkas Sultan , Shayeb Shaheen , Bransi Narmeen
Published: March 2024

The spreading aspects of the seventeen sustainable development goals have been of concern to ‎researchers in education worldwide. These goals have shed the light and grasped the attention to ‎very crucial issues. The significance of these issues (the cores of each SDG) not only lie in their ‎importance but also in their connectedness and mutual influence among each other. Education, ‎being the highest peak of achievement in every society, and hence in the whole (small) world, is ‎directly affected by each SDG. That was the reason for considering the future of Education in sight ‎of one of the most effective sustainable goals, namely, peace, justice and strong institutions. The ‎current paper is a position paper that discusses the float of the sixteenth sustainable goal along the ‎future of Education. The researchers propose two statements: firstly, SDG 4 (Quality Education) ‎and SDG 16 possess a reciprocal interaction property (i.e. they have mutual impact ‎on each other). ‎Secondly, this cyclic process has to start by first accomplishing SDG 16‎‏.
Factors causing students’ learning difficulties in Biology subject
Authors: Azhari Sopian , Rizaldi Dedi Riyan , Fahrurrozi Muhammad , Nilwan Nilwan , Ahyani Nurul
Published: March 2024

This study aims to determine the factors that cause learning difficulties for class X MIPA students at Madrasah Aliyah Plus Nurul Islam Sekarbela. This research is a qualitative research. The subjects of this study were students of class X MIPA at MA Plus Nurul Islam Sekarbela. The sampling technique used random sampling with a sample of 22 students. The research data collection method uses an observation sheet in the form of a questionnaire. The data analysis technique uses descriptive qualitative with percentage categories. The results showed that in general the factors causing learning difficulties in class X MIPA students at MA Plus Nurul Islam Sekarbela consisted of internal factors including and physiology by 43% and psychology by 61%. While external factors include aspects of the family environment by 46%, school environment by 57%, and community environment by 66%.
Learning advertising text using Canva media at junior high school
Authors: Putra Muhammad Yani , Prasetyo Sri Kukuh , Raditya Ria , Astuti Ariesty Fuji , Ekici Gail
Published: March 2024

This research aims to describe the use of Canva media in Indonesian language learning, especially advertising text materials, slogans, and posters for eighth-grade students of junior high school. This research used a descriptive qualitative method to figure out how the use of Canva could impact on the students’ performance during the classroom session. The subjects in this research were 32 eighth-grade students at SMP Negeri 5 Yogyakarta, a public junior high school located in Yogyakarta, Indonesia. The findings provides the insights that the use of Canva media in learning advertising texts, slogans, and posters can improve the students’ learning outcomes, thinking skills, and their ability to master digital technology at the learning.
Developing pop-up book teaching materials on polyhedron to improve junior high school students' mathematical literacy
Authors: Puspaningrum Brilliant Cahya , Istihapsari Vita
Published: March 2024

This research was motivated by the problems found at SMP N 1 Bantul, a junior high school in Bantul regency, Yogyakarta, which were obtained by conducting interviews with mathematics teachers. We found that there were still many students who had not received good stimulation in cognitive development at the concrete stages so that when entering the formal stages students have difficulty to make reasoning into more complex problems where this reasoning will affect students' mathematical literacy skills. Besides, they also lack of teaching materials especially in grade 7 due to using the new curriculum. One of which are the material of polyhedron which only explains concepts in general and does not explain further than the elements, content, and spatial components as well as the visualization of geometric shapes. This study aims to develop pop-up book teaching materials on polyhedron to improve the students' mathematical literacy skills. This development research used the analysis, design, development, implementation, and evaluation (ADDIE) model involving students of class VII-A in the testing. Before conducting testing in the classroom, the teaching materials, pretest, and posttest were validated by experts. The results are: (1) scores of material experts and media experts gave a valid result; (2) the students and teachers responses to teaching materials gave practical testimonies; and (3) there was an average increase from pretest to posttest results at 25.49 points.
Identifying senior high school students' learning styles at a diagnostic assessment
Authors: Sofhiya Evie Nur , Ivo Diana Pungki Astro , Setyowati Djiwanti Retno , Febrianti Novi , Altawil Abdulmohsin Nasser
Published: March 2024

Learning style can be interpreted as the process of appreciation, behavior, and tendencies of a student in acquiring knowledge. One of the keys to student success in the learning process is that it is influenced by a learning style that suits the students. This research aims to identify the learning styles of class XI students at SMA Negeri 4 Yogyakarta. This research is a type of survey research. The research population was all class XI students at SMA Negeri 4 Yogyakarta. The sample was taken from 72 students from class XI F3, F5, and F6 of SMA Negeri 4 Yogyakarta, which was determined using purposive sampling. Data analysis was carried out descriptively presenting the results obtained from closed questionnaires. The overall results obtained in this study show a kinesthetic learning style with a percentage of 36.1%. Class F3 tends to be kinesthetic and F5 and F6 tend to be visual.
The Aspects Of Critical Thinking Toward Students' Psychomotor Skill In Learning Of Microprocessor And Microcontroller Programming Techniques
Authors: Buditjahjanto I.G.P. Asto , Wildan Habibi Mohammad , Sulistiyo Edy
Published: March 2024

This study aims to determine the effect of critical thinking aspects on students' psychomotor skills. Aspects of critical thinking include interpreting, planning, predicting, analyzing, evaluating, and decision-making. This research was applied to a microprocessor and microcontroller programming technique subject at a vocational higher school in Surabaya-Indonesia. The multiple linear regression method was chosen to analyze the effect of simultaneous and partial aspects of critical thinking on students' psychomotor skills. The results showed that there was a significant influence between aspects of critical thinking simultaneously on students' psychomotor skills. While partially, only the predicting aspect has a significant influence on students' psychomotor skills. For other aspects, there is no significant effect on students' psychomotor skills.
Quranic Leadership: The Effort to Realize the Integrity of Leaders in Preventing Corruption
Authors: Chanifah Nur , Samsudin Abu , Hajar Ansori Ibnu
Published: March 2024

This Study aims to analyse how the Quran explains the integrity of leaders as an effort to prevent corruption in Indonesia. This is urgent, because the problem of corruption cannot only be solved by building a legal and judicial system, but also requires prevention efforts through character building, especially related to leaders. It is categorized qualitative research with literature review by conceptual approach. The research analysis uses descriptive-qualitative analysis with the stages, namely editing, classifying, and conclusion. The results showed that the Quranic Leadership to prevent corruption in Islam is reflected in the character or personality of the Prophet Muhammad, namely shidiq (honest), amanah, fathanah (intelligent), and tabligh (communicative and transparent). If it is associated with leadership characteristics described by all classical and modern management experts such as the theories of Warren Bennis and James O'Tool, then these characteristics have been reflected by the Prophet Muhammad throughout his life. Even the Prophet had first applied it through the instructions of Allah SWT contained in the holy book, Qur’an.
Factors Affecting Student Drop Out Behavior: A Systematic Review
Authors: Banaag Rethse , Sumodevilla Jasmine Louise , Potane Joel
Published: March 2024

Factors affecting student dropout behavior have been investigated overtime.  A lot of factors came out to be affecting this prevalent concern in schools. However, in this study, a systematic review of peer-reviewed, empirical literature and studies published between 2015- 2023 was conducted to identify the common factors affecting student dropout behavior and interventions implemented to minimize dropout rates. This review specifically tackles two key issues: First, what are the common factors affecting student dropout behavior? Second, what are the common initiatives and or interventions in reducing student dropouts? A total of 12 studies were included in the review which passed the PRISMA diagram guidelines, Critical Appraisal Skills Programme (CASP) checklist, and were organized using a literature matrix. Results showed that family, school, school/teacher, lack of guidance and counseling, social, individual, and socioeconomic factors were the common factors influencing student dropout behavior. Additionally, it showed that remedial programs addressing lack of interest, support and resources, improving the school's guidance program, offering mechanisms for support to counteract the impact of poverty, transportation and counseling services, increased funding for disadvantaged students, raising awareness of the consequences of pre-marital sex, enforcing school dropout policies, integrating sex education, and guaranteeing adequate resource availability were common interventions implemented to address these prevalent factors.  The findings emphasized the importance of tailored and contextualized interventions in addressing the specific factors. Further research is needed to identify interventions that tailor-fit each factor to structure a more efficient and effective program to address issues related to student dropouts.
Osh risk management of tank sinking procedure using bow tie analysis on the construction of a shell gasoline station in Surabaya
Authors: Wijaya Oktomi , Sugiyana Laely Ufiz Tsani
Published: March 2024

Introduction: The rate of work accidents in the construction sector is still high. Such a situation has led to the need for risk management in the area of Occupational Safety and Health (OSH). This study is aimed at finding the OSH risk management of the tank sinking procedure using Bow Tie Analysis method in the construction of a Shell Gasoline Station in Surabaya.
Methods: This is a qualitative descriptive study with case study design. The subjects of the study were the employees of PT Usaha Jaya Engineering who worked on the Tank Sinking procedure in the construction of a Shell Gasoline Station in Surabaya with the minimum service period of 2 years and with a total number of 7 people.  Data collection was executed using primary data derived from interviews and field observation as well as secondary data in the forms of supporting documents from the company.
Results: As many as 9 hazards were found in the tank sinking procedure in the construction of a Shell Gasoline Station in Surabaya. These hazards were caused by 5 factors, i.e., human, machine/equipment, method, material, and environment. The possible consequence of such hazards is that the employees may experience light to serious injuries and even fatality. Prevention and mitigation measures might be implemented in 4 hierarchical steps of risk management, i.e., substitution, technical management, administrative management, and personal protective equipment (PPE). This study found 6 escalation factors and the barrier of escalation factor in the tank sinking process.
Conclusion: The tank sinking procedure in the construction of a Shell Gas Station in Surabaya was a job with risks of work accident. Prevention and mitigation measures derived from the Bow Tie analysis might be implemented to prevent work accidents from occurring.
Correlation between the factors of unsafe acts and unsafe conditions and the occurrence of work accidents among construction workers (a case study of PT X at Hospital Y project)
Authors: Nabila Salwa Putri Nabila , Widowati Evi
Published: March 2024

Backgrounds: Generally speaking, unsafe acts and unsafe conditions are the causes of work accidents. Based on the HSE reports, the cases of occupational accidents in the Hospital Y project in the last 7 months until October 2021 had amounted to 20. The correlation between the unsafe acts as well as unsafe conditions and the occurrence of work accidents constitutes the basis and objectives of this study.
Methods: This study is quantitative in nature, with analytical observation implementing cross sectional approach. It involved 63 out of 130 workers (consisting of staff, supervisors, and subcontractor workers) who were selected using purposive sampling technique. Instruments in the forms of questionnaires, observations, and documentary studies were implemented. The data were further analyzed using chi-square test, fisher test, and cell pooling.
Results: It was shown from the statistics that the Occupational Safety and Health (OSH) Knowledge gained the score of (p=0,066; PR=1,368; 95%CI=0,995-1,879), Load of Work (p=0,010; PR=0,647; 95%CI=0,457-0,916), OSH Training (p=0,029; PR=1,833; 95%CI=0,873-3,848), Equipment Safety Gear (p=0,005; PR=1,682; 95%CI=1,102-2,567), and Operational Procedures (p=<0,0001; PR=1,934; 95% CI=1,251-2,991).
Conclusions: It is found that no correlation was existent between OHS Knowledge occurrence of work accidents. However, there was a correlation between work load, OSH training, and equipment safety gear and the occurrence of work accidents.
Correlation between implementation of health protocol and compliance among employees of Mutiara department store Slawi in the prevention of Covid-19
Authors: Pratiwi Anggit , Subekti Agung Tyas , Rakhmadi Triyono
Published: March 2024

Background: Covid-19 pandemic has affected various aspects. One of them is the shopping center/retail sector since a shopping center is a place which is susceptible to the dissemination of SARS-CoV-2 viruses so that health protocols should be implemented and employees should comply with the health protocols in the workplace.
Objective:  The study is aimed at finding the correlation between the implementation of Covid-19 health protocols and compliance among employees of Mutiara Cahaya Department Store Slawi. 
Method: This is a quantitative correlative study with cross-sectional design. The research subjects were all employees of Mutiara Cahaya Department Store Slawi with the sample consisting of 48 respondents. 
Data Analysis: Data were analyzed using a univariate test in the form of frequency distribution and a bivariate test using Chi-Square. The results of the analysis showed that the implementation of Covid-19 health protocols in Mutiara Cahaya Department Store Ciawi ran quite well (39.59%) with employees’ compliance which was good as well (64.58%). The results of the research showed that there was a significant correlation between the implementation of health protocols and employees’ compliance with (pValue = 0,000) meaning that if the health protocol is good then the employees’ compliance is also good.
Conclusion: Compliance with the implementation of health protocol which has been performed by the employees and management of Mutiara Cahaya Department Store Ciawi included mask wearing, hand washing, temperature check for employees and visitors, limitation of operational hours, provision of >1 meter distancing marks, installation of separators on cashier desks, and workplace cleaning with disinfectants.
The effect of muscle stretching on the reduction of pain caused by Occupational Cervicobrachial Disorders (OCD) among mechanics at a Honda service workshop in Umbulharjo Yogyakarta
Authors: Zulhayudin Muhammad Fadillah
Published: March 2024

Occupational Cervicobrachial Disorder (OCD) is a functional and/or organic disorder at the upper extremity due to neuromuscular fatigue caused by working activities at a fixed position or with repeated movements. The rate of musculoskeletal system disorder among mechanics in a number of countries has amounted to 76-92%. A preliminary survey using Nordic Body Map Questionnaire showed that the mechanics at a Honda workshop in Umbulharjo felt the work-related pain at the upper extremity. Therefore, intervention was deemed required to reduce such pain. Muscle stretching was selected as the intervention to be provided. This study is aimed at determining if muscle stretching has an effect on the reduction of OCD related pain among the mechanics at a Honda workshop in Umburharjo Yogyakarta. The study was quantitative in nature with quasi-experimental design. Based on cluster sampling technique with tracer survey methods, 30 samples were selected and divided into 2 groups, i.e., intervention group with 20 respondents and control group with 10 respondents. The measurement of pain scale was performed using Visual Analog Scale. The research results showed that there was significant reduction of pain scale upon the intervention of muscle stretching with the frequency of 6 times per week. Hence, the study comes up with a conclusion that muscle stretching has the effect on the reduction of pain caused by OCD among the mechanics at a Honda motorcycle workshop in Umbulharjo Yogyakarta.
The roles of cognitive ergonomics in reducing human error and burnout among emergency room nurses during the Covid-19 pandemic
Authors: A.P. Rezki Amelia Aminuddin , Hakim Hakim
Published: March 2024

Background: Mental health, particularly burnout syndrome, is one of the concerns that can influence the productivity of health workers during the pandemic. This is because health professionals are under intense pressure, but there is no guideline or procedure in place to safeguard them in terms of mental health. The objective of this study is to discover burnout and human error, as well as to provide advice, by analyzing the ergonomic factors.
Method: Human Error Assessment and Reduction Technique was the identifying approach employed (HEART) in this study. The sample consisted of ten emergency room personnel from one of the hospitals in Yogyakarta.
Results: The activity with the greatest HEP was the delivery of first aids, which had a value of 0.068. This activity requires more difficult and complex labor abilities, making human unreliability more significant and increasing the likelihood of human error.
Conclusion: Recommendations are made to assist nurses in dealing with heavy and varied workloads so that the reliability of nurses at work can be increased and burnout can be reduced, including the suppression of environmental factors to be as small as possible to reduce the workload of nurses, urging nurses to begin monitoring the situation and taking anticipatory steps so that the burnout does not worsen, and holding regular sharing sessions among nurses, upgrading knowledge and fostering a sense of togetherness.
Work accident reporting in coal mining, Indonesia: A systematic literature review
Authors: Sultan Muhammad , Setyadi Djoko , Ramdan Iwan Muhamad , Haviluddin Haviluddin , Hidayati Tetra
Published: March 2024

Background: Work accidents and work-related diseases are still considered as nightmares in Indonesia, especially in the coal mining sector. Badan Penyelenggara Jaminan Sosial (BPJS) Ketenagakerjaan (Social Security Agency for Employment) reported that there were as many as 234,370 cases of work accidents and work-related diseases in 2021, where the mining sector contributed as many as 6,565 cases. This study aims to present the analysis and synthesis of various research to provide solution recommendations in the management of accident reporting which are suitable to the characteristics of coal mining in Indonesia.
Method: This study is a Systematic literature review of a number of studies sourced from Elsevier, Science Direct, Google Scholar, Pubmed, Proquest, DOAJ, Perpusnas RI, Garuda, and other sources.
Results: Based on the literature analysis, it is found out that reporting management based on digitalization either in the form of website portal or application is a solution to optimize the effort to control work accidents and work-related disease in coal mining.
Conclusion: This reporting system can be applied in coal mining in Indonesia.
Risk management exploration of occupational safety and health for coconut tappers of Nira Satria Cooperative in Banyumas regency
Authors: Permatasari Indah
Published: March 2024

Background: Occupational safety and health (K3) for informal sector is still low, as evidenced by the increasing trend of work accidents by 5-10%, including work accidents experienced by coconut tappers. Currently, there are only few research discussing about the implementation of SMK3, especially those dealing with risk management in reducing and preventing work accidents for coconut tappers. The objective is to explore the implementation of risk management for coconut tappers in working group of Nira Satria Cooperative, Banyumas Regency.
Method: This qualitative research used a case study approach. It was conducted in two villages, namely Sokawera and Pageraji. There were ten research informants involved in this research consisting of the Chief of Pageraji and the Chief of Sokawera, the staff of community health center, the staff of Cooperative, the family of coconut tappers, and the coconut tappers of Nira Satria Cooperative. Data collection was carried out by in-depth interviews and field observations.
Results: A total of 702 coconut tappers in Banyumas Regency were reported to have had accidents over the last five years. The work accidents experienced by coconut tappers of Nira Satria Cooperative were influenced by three factors, namely knowledge, availability of PPE, and behavior. The informants’ knowledge of risk management was very limited, five out of nine informants interviewed were still unable to identify and assess risk at work. The availability of PPEs is only 10% of the total tappers and when used they hindered the tappers’ time and work. The behavior of coconut tappers at work did not reflect good practice of risk management.
Conclusion: Coconut tappers of Nira Satria Cooperative had not implemented risk management properly, there were no strict rules from the Cooperative and there was no support from the stakeholders. The coconut tappers and the stakeholders should have awareness to prioritize the safety and health of the coconut tappers in Banyumas Regency, especially those of Nira Satria Cooperative.
Development of audiovisual media to improve OSH knowledge among construction workers of PT Sasmito at the construction project of FMIPA building at UGM Yogyakarta
Authors: Sekar Meilana Nawang , Arianto Machfudz Eko , Saptadi Julian Dwi
Published: March 2024

Background: Work accidents with a high rate of fatality are dominated by the ones in construction work. Accidents could be caused by a number of factors, one of them is workers’ behavior. Knowledge and audiovisual media are the supporting factors and predispositions that influence workers’ behavior. Some workers have not understood the function of Personal Protective Equipment (PPE) and the standard application of PPE. This study is aimed at finding out the feasibility of audiovisual media and the average level of OSH knowledge among the workers before and after intervention.
Method: This is a Level 4 Research and Development (RnD) study consisting of Product Design, Product Validation, Product Revision, and Limited Trial. The sample were the workers of PT Sasmito at the construction project of FMIPA building in UGM Yogyakarta consisting of 40 people. Validity test of the media was conducted by distributing questionnaires to material and media experts. Limited trial was conducted by distributing the questionnaire before and after intervention. Data analysis was carried out using univariate and bivariate analysis, i.e. Wilcoxon sign rank.
Results: The total scores resulting from the validity tests were 76% by the material experts and 85% by the media experts, meaning that the audiovisual media was categorized as “feasible” and “highly feasible”. Hence, the audiovisual media was feasible or appropriate to be presented to the construction workers. The average rates of OSH knowledge among the workers were 11.20 for the pre-test and 13.8 for the post-test, respectively. The Wilcoxon Sign Rank test resulted in the p-value of 0.000 (<0.05), meaning that there was a difference in the average rate of OSH knowledge between the conditions of before and after the provision of audiovisual media to the construction workers of PT Sasmito at the construction project of FMIPA building at UGM.
Conclusion: Audiovisual media is feasible to be presented and there is a difference in average rate of the workers’ knowledge on the PPE application between the conditions before and after the intervention. Companies are expected to use audiovisual media as a means to promote OSH.