bluuebunny/crossref_metadata_2025 huggingface dataset:
Prognosis value and positive association of Rab1A/IL4Rα aberrant expression in gastric cancer
Authors: Li Haoran , Cheng Zhengwu , Jiang Bin , Shao Xinyu , Xu Menglin
Published: December 2022

Gastric cancer (GC) is the most common gastrointestinal cancer with the leading causes of cancer-related death worldwide. Many GC patients are diagnosed at the advanced stage, the five-year survival rate is unsatisfactory. Rab1A expression was significantly correlated with IL4Rα expression in non-small cell lung cancer. However, the potential correlation of Rab1A and IL4Rα in both expression and prognosis remain largely unknown in gastric cancer. In this study, Rab1A/IL-4Rα was obviously elevated in GC tissues compared with the para-cancerous tissues and Rab1A/IL-4Rα overexpression led to poor prognosis in GC patients. Rab1A expression was remarkably associated with the expression of IL-4Rα in GC tissues by IHC analysis. In addition, the mRNA expression of Rab1A was closely related with the IL-4Rα mRNA expression by qPCR in GC tissue. Furthermore, the Kaplan-Meier analysis indicated that the group with both negative of Rab1A and IL-4Rα expression had longer five-year survival rates compared with the other group. Besides, the group with both positive of Rab1A and IL-4Rα expression had a worse prognosis compared with the other group. Finally, the nomograms predicting 3 and 5-year overall survival revealed that Rab1A/IL-4Rα expression played crucial roles in predicting the prognosis of GC patients. Therefore, Rab1A/IL-4Rα may played a vital role in GC, which may provide a new visual field on the targeted therapy of GC.
A novel score to estimate thrombus burden and predict intracranial hypertension in cerebral venous sinus thrombosis
Authors: Wang Zhongao , Dandu Chaitu , Guo Yibing , Gao Meini , Lan Duo , Pan Liqun , Zhou Da , Ding Yuchuan , Ji Xunming , Meng Ran
Published: December 2022

Background: The current methods to evaluate the severity of cerebral venous sinus thrombosis (CVST) lack patient-specific indexes. Herein, a novel scoring method was investigated to estimate the thrombus burden and the intracranial pressure (ICP) of CVST.
Methods: We consecutively included eligible patients, with a first-time diagnosis of CVST by contrast-enhanced magnetic resonance venography (CE-MRV) or computed tomography venography (CTV), in this retrospective study from January 2019 through December 2021. A comprehensive CVST-Score was established according to magnetic resonance black blood thrombus imaging (MRBTI) to estimate the thrombus burden semi-quantitatively. The relationship between CVST-Score and ICP was explored to assess its potential to monitor ICP noninvasively.
Results: A total of 87 patients were included into the final analysis. The CVST-Scores in different ICP subgroups were as follows: 4.29±2.87 in ICP＜250mmH2O subgroup, 11.36±3.86 in ICP =250-330mmH2O subgroup and 14.99±3.15 in ICP＞330mmH2O subgroup, respectively (p<0.001). For patients with ICP ≤330mmH2O, CVST-Scores were linearly and positively correlated with ICP (R2=0.53). The receiver operating characteristic (ROC) curves showed the optimal CVST-Score cut-off values to predict ICP ≥250mmH2O and ＞330mmH2O were 7.15 and 11.62, respectively (P<0.001). Multivariate analysis indicated CVST-Score as an independent predictor of ICP ≥250mmH2O (odds ratio, 2.15; 95% confidence interval, 1.49-3.10; p<0.001).
Conclusions: A simple and noninvasive CVST-Score could be employed to rapidly estimate the thrombus burden and predict the severity of intracranial hypertension in patients with CVST. It can be used to evaluate therapeutic responses and avoid unnecessary invasive procedures at long-term follow-up.
Fractional CO2 laser in the treatment of nail psoriasis, how can it help?
Authors: Afify Ahmed Abdelfattah , Shaheen Maha Adel , El-Banna Mahmoud Gamal
Published: December 2022

Background: Treating nail psoriasis is often a time-consuming challenge with an unsecure outcome. Response to the treatment is variable and relapses are common. Systemic treatments have multiple systemic side effects and lack of the patient compliance makes intra-lesional therapies not the best choice for treatment of nail psoriasis. We aimed to evaluate and compare the efficacy and side effects of methotrexate versus calcipotriol plus betamethasone two compound formula when applied topically to psoriatic nails after fractional CO2 laser.
Methods: This comparative pilot study included 20 patients with nail psoriasis. One side was treated with fractional CO2 laser followed by the application of topical methotrexate (Group A) and the other side with fractional CO2 laser followed by topical (Calcipotriol 0.05 mg/gm + Betamethasone 0.5 mg/gm) (Group B). 4 sessions were done, once every 2 weeks. Results: There was a high statistical significant decrease in total NAPSI score in group A at 1(P = 0.000) and 2 months (P = 0.000). There was a high statistical significant decrease in total NAPSI score in group B at 1(P = 0.001) and 2 months (P = 0.001). There was no statistical significant difference regarding total NAPSI score between both group A and B at 0 (P = 0.271), 1(P = 0.513) and 2 months (P = 0.647).
Conclusion: Combined fractional CO2 laser with either topical MTX or topical betamethasone plus calcipotriol two compound formula is effective treatment for nail psoriasis.
To compare the efficacy and safety of radiotherapy before and after anti-CD19-CAR T-cell therapy in patients withrelapsed/refractory DLBCL
Authors: Li Jingyi , Mu Juan , Li Xin , Li Qing , Jiang Yili , Wang Jia , Mou Nan , Deng Qi
Published: December 2022

Background: What is the difference in efficacy and side effects of radiotherapy bridging CAR-T therapy versus CAR-T therapy followed by radiotherapy?
Patients and methods: Fourteen R/R DLBCL patients received radiotherapy before CAR-T therapy (R-C group). R-C group was divided into: 1-3 months radiotherapy before CAR-T therapy (1-3 mons) group and more than 3 months before CAR-T therapy (more than 3 mons) group. Seventeen patients received radiotherapy 2-3 months after CAR-T therapy (C-R) group.
Results: In R-C group, ORR was 81.82% and CR was 54.55%. In C-R group, ORR was 64.71% and CR was only 35.29% after CAR-T therapy, but CR became 64.71% after the following radiotherapy. CAR-T cell peaks were higher in R-C group than in C-R group, and higher in R-C (1-3 mons) group than that in R-C (more than 3 mons) group. Three patients in R-C group died of CRS, no patient in C-R group died of CRS. There was no difference in CRS and ICANS in R-C and C-R group. CRS and ICANS grades were higher in R-C (1-3 mons) group than that in R-C (more than 3 mons) group.
Conclusions: Radiotherapy bridging CAR-T therapy had higher ORR. While, CAR-T therapy followed by radiotherapy might improve CR without higher CRS and ICANS.
Trial registration number ChiCTR1800019622.
PIN1 As A Marker of Metastasis and Survival in Pancreatic Neuroendocrine Tumor Identified by Single-cell Sequencing and Proteomic Profiling
Authors: Wang Min , Yin Taoyuan , Huang Peiwu , Qin Tingting , Chen Dong , Xu Simiao , Gong Jun , Tian Ruijun , Guo Xingjun , Qin Renyi
Published: December 2022

Background
This study aimed to identify new protein markers that can evaluate the metastatic ability of Pancreatic neuroendocrine tumors (PanNETs) and predict prognosis together with Ki-67.
Methods
Multicentric series analysis was performed to evaluate the effect of metastasis on overall survival (N = 1,109). Single-cell RNA sequencing, proteomics (32 PanNETs and 10 normal pancreas tissues), and immunohistochemical staining (152 PanNETs) were conducted to screen proteins associated with PanNET metastatic capability. Associations between expression of screened proteins and survival were examined using Cox regression. In vitro experiments were performed to verify the function of candidate protein. A survival signature was constructed using recursive partitioning and survival forest analyses.
Results
The combination of G grade and metastasis predicted long-term survival more accurately though retrospective analysis. Single-cell RNA-seq highlighted the PanNET characteristics of metastasis that do not correspond with G grade and identified high metastatic capability subgroups in PanNET. Five proteins (PIN1, POSTN, SEMA4F, ASPN, and KCDT12), which may be related to the metastatic capability of PanNETs, were identified by proteomics. Random survival forest analysis showed that PIN1 could be a marker of PanNET metastatic ability. PIN1 overexpression promoted metastasis through LAMIN in PanNET cells. Finally, a survival signature with a consistency index of 0.921 and strong calibration was established, with good ability to predict patient survival.
Conclusion
In summary, we found that PIN1 can precisely evaluate the metastatic potential of PanNETs and, together with the proliferation marker Ki-67, can accurately predict the survival of PanNET patients.
Cancer patient and Caregiver Communication about Economic Concerns and the Effect on Patient and Caregiver Partners’ Perceptions of Family Functioning
Authors: Thomson Maria D. , Wilson-Genderson Maureen , Siminoff Laura A
Published: December 2022

Purpose: Financial strain and stressful life events predict poor family communication. A cancer diagnosis can bring heightened emotional stress and financial strain for most cancer patients and their families. We evaluated how level of comfort and willingness to discuss important but sensitive economic topics affected longitudinal assessments of family relationships, exploring both within-person and between partner effects over two years after a cancer diagnosis.
Methods: A case series of hematological cancer patient-caregiver dyads (n=171) were recruited from oncology clinics in Virginia and Pennsylvania and followed for 2 years. Multi-level models were developed to examine the associations between comfort discussing economic aspects of cancer care and family functioning.
Results: Broadly, caregivers and patients who were comfortable discussing economic topics reported higher family cohesion and lower family conflict. Dyads’ assessments of family functioning were influenced both by their own and their partners level of communication comfort. Overtime caregiver but not patients perceived a significant decrease in family cohesion.
Conclusions: Communicating about potentially delicate topics such as cancer care costs are associated with family functioning long term. Discussing employment in particular appears to be challenging for both members of the dyad.
Implications for Cancer Survivors: In this sample, cancer patients did not perceive the decline in family cohesion that was reported by their family caregiver. This is an important finding for future work that aims to identify the timing and nature to best intervene with caregiver supports to mitigate caregiver burden that may negatively impact long term patient care and QOL.
Dip-phenomenon and analytical model for velocity profile in open-channel bends
Authors: Hu Peng , Wu Di , Xiang Huawei , Yu Minghui
Published: December 2022

The dip-phenomenon whereby the location of the maximum velocity appears below the free surface is related to the advective momentum transport by secondary flow. In open-channel bends, there exist relatively large-scale vorticities termed Prandtl’s secondary flow of the first kind which is remarkably different from Prandtl’s secondary flow of the second kind induced by anisotropy of turbulence in straight channels. Experiments were carried out in a narrow and sharp bend to explore the dip-phenomenon along the bend. It is revealed that at the bend entrance the dip-phenomenon in the outer bank is more pronounced than that in the inner bank, while it is opposite in the rest region. The variation of the dip position reflects the momentum redistribution by the multiple circulation cells developed along the bend. Based on the Reynolds Averaged Navier–Stokes (RANS) equations with a cylindrical coordinate system and the experimental data, a new analytical model for the velocity profile in open-channel bends is proposed. The model verified by the experimental data is able to predict the dip position and velocity profile accurately in both the inner bank and outer bank regions. Two factors are discussed about the effect of the vertical velocity distribution and transverse gradient of secondary flow on the variation of the streamwise velocity profile.
Characteristics, sources, and exposure risk of the carbonaceous species of PM2.5 in Lahore, Pakistan
Authors: Ahmad Mushtaq , Chen Jing , Yu Qing , Lee Heekwan , Khan Muhammad Tariq , Ali Syed Weqas , Nawab Asim , Panyametheekul Sirima
Published: December 2022

Samples of PM2.5are collected and analyzed in the urban areas of Lahore, Pakistan, during the sampling periods of the winter and summertime. The mass concentrations of PM2.5and its carbonaceous species (OC and EC) show a significant variation during both sampling periods. The mean OC concentration in winter and summertime are 50.7 ± 30.5 µg/m3, and 14.6 ± 5.6 µg/m3, whereas EC concentrations are 26.5 ± 18.0 µg/m3and 8.6 ± 3.4 µg/m3, respectively. In the winter and summertime, the OC/EC average ratios reported are 2.1 and 1.9, respectively. There is a strong OC-EC correlation in the wintertime, indicating that they have a common source. The weak OC-EC correlation in the summertime is attributed to increased biogenic emissions and secondary organic aerosol formation through photochemical processes. Secondary organic carbon (SOC) contributes 16.7% of organic carbon in the winter and 22.6% in the summertime sampling. The exposure risk of EC is estimated based on inhalation dose. The higher exposure risk of EC inhalation in winter can adversely affect human health. According to principal component analysis (PCA), the major sources of the carbonaceous species of PM2.5at Lahore included vehicle emission, secondary organic aerosol formation, emissions from combustion sources, and dust. The potential source contribution function (PSCF) and trajectory cluster analysis also demonstrated that the high concentrations of PM2.5and its carbonaceous species in Lahore resulted from regional and local pollution sources.
Biodiversität und Naturschutz in Nils Holgerssons wunderbare Reise durch Schweden (1906/1907)
Authors: Felcht Frederike
Published: December 2022

[English title and abstract below]
1901 bat der Reformschullehrer Alfred Dalin im Auftrag von Sveriges allmänna folkskollörareförening (Schwedens allgemeiner Volksschullehrervereinigung) die ehemalige Lehrerin und populäre Autorin Selma Lagerlöf um die Erstellung eines neuen Geografielehrbuchs. Gedacht war an eine Anthologie verschiedener Texte, doch Lagerlöf bestand darauf, ein zusammenhängendes künstlerisches Werk zu verfassen. So entstand die Geschichte von Nils Holgersson, der auf dem Rücken einer Gans durch Schweden reist.
Aufbauend auf Ansätzen aus Ecocriticism und Cultural and Literary Animal Studies untersucht mein Artikel Beziehungen zwischen dem Schulbuch und dem ökologischen Diskurs um 1900, mit einem Fokus auf der Rolle von biologischer und ästhetischer Vielfalt in Nils Holgerssons wunderbarer Reise durch Schweden. Biologische und ästhetische Vielfalt bilden in dem Schulbuch eine Einheit, so meine These, die mit dem ökologischen Denken um 1900 korrespondiert. Das Schulbuch vereint unterschiedliche Stimmen, Genretransgressionen und eine komplexe linguistische und narrative Struktur. Seine einzigartige Verbindung von Fakten und Fiktion ermöglicht es, diese formalen Eigenschaften in Beziehung zu setzen zu Reflexionen über biologische Vielfalt in Nils Holgerssons wunderbarer Reise durch Schweden und im Naturschutzdiskurs um 1900.
Biodiversity and Nature Conservation in The Wonderful Adventures of Nils (1906/1907)
In 1901, the progressive educator Alfred Dalin, on behalf of the Swedish Primary School Teachers Association, asked the former teacher and popular author Selma Lagerlöf to create a new geography textbook. They had an anthology of texts in mind, but Lagerlöf insisted on writing a new work instead. The story of Nils Holgersson, who travels through Sweden on the back of a goose, is the famous result. Based on approaches from ecocriticism as well as cultural and literary animal studies, this article examines the relationship between the textbook and environmental discourse around 1900. It postulates that biological and aesthetic diversity in The Wonderful Adventures of Nils form a unit in the textbook, a unit that corresponds to ecological thinking around 1900. The textbook contains a variety of voices; it transgresses genres and has a complex linguistic and narrative structure. Its original combination of fact and fiction makes it possible to relate these formal features to reflections on biological diversity in the book itself and in environmental discourse around 1900.
Nutzungsmöglichkeiten von Mobilitätsdaten in der Region Frankfurt Rhein-Main
Authors: Blechschmidt Andreas , Schönduwe Robert , Lanzendorf Martin
Published: December 2022

Elementar für eine zukunftsfähige Verkehrsplanung ist eine möglichst detaillierte Kenntnis des Mobilitätsverhaltens der Bevölkerung in der Region. Zur Analyse des Mobilitätsverhaltens der Bevölkerung in Deutschland wurden in der Vergangenheit auf verschiedenen räumlichen Ebenen mehrere größtenteils voneinander unabhängige Datenerhebungen durchgeführt. Für die Region Frankfurt Rhein-Main besonders relevant sind dabei zum einen die Längsschnitt- bzw. Panelerhebungen des „Rhein-Main-Panels“ (RMP) und des „Deutschen Mobilitätspanels“ (MOP), zum anderen die Querschnittserhebungen der Befragung „Mobilität in Deutschland“ (MiD) und speziell für Frankfurt auch „Mobilität in Städten – SrV“ (SrV). Ziel dieser Publikation ist es, diese vier unterschiedlichen Erhebungen in einem kurzen Vergleich vorzustellen. Dabei sollen die jeweiligen spezifischen Potentiale, aber auch Einschränkungen aufgezeigt werden, die diese Mobilitätsdatensätze bezüglich der Auswertung und weiteren Nutzung aufweisen. Danach werden in knapper Form mögliche Kombinationsmöglichkeiten dieser Datensätze untereinander, aber auch mit ergänzenden Datenbeständen dargestellt. Anschließend werden die aus den verschiedenen Mobilitätsdatensätzen ermittelten zentralen regionalen Mobilitätskennziffern in einem Vergleich veranschaulicht. Als Abschluss soll schließlich ein kurzer Blick auf mögliche Anwendungsfelder der Mobilitätsdaten in Politik und Planung geworfen werden.
Pluralismo y verdad: del liberalismo clásico a la posmodernidad tardía
Authors: Sáez-Mateu Ferrán , Sintes-Olivella Marçal
Published: December 2022

En el contexto de la comunicación de masas, el uso rutinario del término “pluralismo” ha generado un desgaste semántico que aconseja una nueva exploración del concepto a la luz de referentes históricos, filosóficos y filológicos adecuados. Este es justamente el objetivo del presente escrito. En efecto, la noción de “pluralismo” asociada a las primitivas formulaciones de la democracia clásica griega tiene muy poco que ver con lo que posteriormente defendió el liberalismo de finales del siglo XVIII y mediados del XIX, un teórico contemporáneo de la democracia como Habermas, o el movimiento posmoderno durante los años ochenta. Si bien es cierto que nadie se opone al pluralismo, también lo es que la adscripción a dicho concepto obedece a parámetros muy diferentes. Habermas y algunos autores posmodernos apuestan por el debate colectivo plural, especialmente el mediático, pero tanto su punto de partida como sus conclusiones resultan divergentes.
Adorno sobre Kafka. ¿Una lectura ilustrada?
Authors: Bartoli Fabio
Published: December 2022

El artículo analiza la interpretación que Adorno hace de Kafka en Apuntes sobre Kafka, concentrando la atención en la consideración sobre Kafka como un escritor ilustrado que critica la Ilustración, con el fin de determinar si dicha afirmación es o no coherente con la teoría adorniana. Para esto, se compara la lectura que Adorno y Kafka hacen del episodio del canto de las sirenas de la Odisea y se analizan las diferencias existentes entre las dos interpretaciones. Gracias a ello podemos concluir, parcialmente en contra de Adorno, que Kafka es un crítico de la Ilustración, aunque no es un escritor ilustrado
El concepto de “plasticidad” en las primeras obras de Catherine Malabou
Authors: Martínez i Cuadras Albert
Published: December 2022

Ya en su tesis doctoral, Malabou (1996) empieza a elaborar, a partir de una relectura de Hegel, una noción que recorrerá toda su obra: el concepto de “plasticidad”. En este artículo analizamos las principales apariciones de dicho concepto en los primeros trabajos de la autora francesa. En ella, dialoga especialmente, y de manera declarada, con Hegel, Heidegger y Derrida, prometiendo un concepto de la esencia o la forma que incorpore la diferencia sin negarla. Si bien el concepto de “plasticidad” en la obra de Malabou ha sufrido un giro, según el cual ha entrado en un diálogo abierto con la biología y, más concretamente, con las neurociencias contemporáneas, en el presente artículo veremos su estatuto antes de dicho giro.
*e-mail: jez@unb.br Editor handled this article: Ivo M. Raimundo Jr. (Associate) Diffuse Reflectance FTIR of Latent Fingerprints and Discriminant Analysis for Sex Identification in Humans
Authors: de Souza Marco Antonio , Santos Alexandre , da Silva Sebastião William , Braga Jez Willian , Sousa Marcelo Henrique
Published: December 2022

Latent fingerprint is an important crime scene evidence, but it is not always recoverable or technically suitable for analysis with fingerprint patterns. Forensic science has shown that other information can be explored from traces using chemical compounds. Infrared spectroscopy is a nondestructive technique that is widely applied to a variety of forensic evidence. In this work, infrared spectroscopy and partial least square discriminant analysis were used to determine the human sex based on latent fingermark analysis. Fingerprint samples were taken from 42 male and female donors, then kept in either dark or light storage conditions, and the Fourier transform infrared (FTIR) spectra were measured considering a period of up to 30 days from collection. The regions from 3000 to 2800 cm-1 and 1790 to 1150 cm-1 presented the greatest differences in the peak intensities among the two sex groups. The results showed a correct discrimination rate higher than 80%.
Una aproximación a la tipología de las casas de pescadores de la costa vasca durante la Edad Moderna: Zeria etxea (Hondarribia, Gipuzkoa)
Authors: Diez Oronoz Aritz , Narbarte Josu , Telleria Ibon , Susperregi Josue
Published: December 2022

Frente a los numerosos trabajos realizados en torno al caserío, la arquitectura vernácula de las comunidades pesqueras del País Vasco ha sido hasta la fecha muy poco estudiada. Este artículo propone una primera aproximación a esta temática, planteando el primer estudio arquitectónico de una casa de pescadores del arrabal de la Magdalena (Hondarribia, Gipuzkoa), la casa Zeria. Mediante una combinación de fuentes documentales, cartográficas, fotográficas e iconográficas, así como el estudio de las estructuras conservadas y su contexto urbano, se ha podido reconstruir en detalle la historia de la casa y del arrabal, poniéndola en relación con los modos de vida de la comunidad marítima local y su relación con la villa. El estudio abre una línea de trabajo hasta ahora poco explorada en el País Vasco, que tiene sin embargo un gran potencial de investigación en esta y otras localidades del entorno.
Geometry and Topology of Conceptual Representations of Simple Visual
Data
Authors: Dolgikh Serge
Published: December 2022

Introduction:

Representations play an essential role in learning artificial and biological
systems by producing informative structures associated with characteristic patterns in the sensory
environment. In this work, we examined unsupervised latent representations of images of basic geometric
shapes with neural network models of unsupervised generative self-learning.

Background:

Unsupervised concept learning with generative neural network models.

Objective:

Investigation of structure, geometry and topology in the latent representations of generative
models that emerge as a result of unsupervised self-learning with minimization of generative
error. Examine the capacity of generative models to abstract and generalize essential data characteristics,
including the type of shape, size, contrast, position and orientation.

Methods:

Generative neural network models, direct visualization, density clustering, and probing
and scanning of latent positions and regions.

Results:

Structural consistency of latent representations; geometrical and topological characteristics
of latent representations examined and analysed with unsupervised methods. Development and verification
of methods of unsupervised analysis of latent representations.

Conclusion:

Generative models can be instrumental in producing informative compact representations
of complex sensory data correlated with characteristic patterns.
Real-Time Location, Correction and Segmentation Algorithm based on
Tilted License Plate
Authors: Gao Zhiyong , Xiang Jianhong
Published: December 2022

Background:

Vehicles have become one of the most important means of transportation, and license plate is the only identifying mark of vehicles. License plate recognition technologies are being applied to a series of occasions, such as supervising road traffic violations, recovering stolen vehicles, monitoring wanted vehicles, and dispatching special vehicles. The license plate tilt phenomenon caused by various reasons has brought great trouble to its own recognition.

Objective:

How to identify tilted license plates efficiently and accurately becomes the key to the automatic management of a large number of vehicles. Therefore, a real-time location, correction and segmentation algorithm based on the tilted license plate is proposed in this paper.

Methods:

Firstly, an end-to-end deep convolutional neural network (CNN) is proposed for the location detection of the tilted license plate. The developed CNN is optimized by the most advanced RefineDet algorithm. By improving the object detection module, the representation ability of the CNN for small features and the accuracy of the detector are improved, so as to make the location regression and label prediction of the detected object more accurate. Secondly, the optimized perspective transformation algorithm is applied to correct the tilted license plate. According to the vertices coordinates of the bounding box detected by our CNN, the license plate area cropped out from the original image has a certain tilt angle, and the perspective transformation algorithm achieves the correction. Finally, digital image processing technology is used to segment the characters of license plates.

Results:

The experimental results in the Chinese City Parking (CCP) dataset show that the proposed algorithm exhibits location average precisions improvements of 2.4-5.4% over the other algorithm.

Conclusion:

The proposed algorithm achieves high-accuracy correction and real-time segmentation.
Implementation of Blockchain Technology for Big Data
Authors: Afaq Yasir , Vaseem Akram Shaik , Singh Rajesh , Shafiq Mohammad
Published: December 2022

The focus of this chapter is to provide brief knowledge about the concept
and advantages of integrating Big Data and blockchain technology. As we are focusing
on the blockchain and Big Data, it is suitable to introduce Big Data before exploring its
interactions with blockchain. The blockchain technology is introduced and then the
interaction between blockchain technology and Big Data is focused, in order to gain a
clear understanding of how blockchain technology is used for Big Data. Thereafter, the
different applications of blockchain and Big Data are explored.
Aurone Scaffold and Structural Analogues for the Development of Monoamine Oxidase (MAO) Inhibitors
Authors: Guglielmi Paolo , Pontecorvi Virginia , Akdemir Atilla
Published: December 2022

Continuous efforts in the development of monoamine oxidase inhibitors

prompted the search for effective strategies for the design of novel drugs candidate.

Thankfully, nature often provides scaffolds useful for the promotion of novel

exploitable chemical entities. In this regard, aurones (a class of uncommon flavonoids)

and their structural related analogues may play an important role in the development of

monoamine oxidase inhibitors. The target prediction of the simplest aurone (2-

benzylidenebenzofuran-3(2H)-one) clearly suggests that this compound probably

affects MAO (monoamine oxidase) enzymes, which is in accordance with the recently

reported literature. The current chapter reports the recent discoveries involving aurones

and their structurally related analogues as MAO inhibitors, describing detailed

structure-activity relationships (SARs) for each subgroup of compounds.
Risk Factors of Covid-19 Enhancing Transmission and Aggravating Patient’s Condition
Authors: Trivedi Vishal , Nautiyal Vinod , Widyowati Retno
Published: December 2022

For the last couple of years, novel coronavirus or SAR-CoV-2 is a severe threat to the world. This new strain of coronavirus emerged on 14th December 2020 and has been infecting many parts of the population around the world to date. These viral spikes will bind with the angiotensin-converting enzymes. Many clinical studies conducted have highlighted the association between cardiovascular diseases and COVID-19. It increases the mortality rate, the risk of injury in myocardial, acute coronary syndromes and thromboembolism. COVID-19 has produced some risk factors such as age and gender as well as comorbidities. Coronavirus may pose several challenges for oncology patients. Among cancer patients, severe respiratory and systemic infection are evident specifically among immunosuppressed and ageing patients. Cancer is said to worsen due to COVID-19 as it is linked with inflammatory burst and lymphopenia. This study has discussed the risk factors in COVID-19 transmission, factors that can aggravate it and clinical interactions between the cardiovascular system. Furthermore, several drugs that have been administered against the virus are believed to affect the patients.
Política de Comunicação no âmbito Bibliométrico: cultivo de impasses, potencialidades e desafios
Authors: Miguel Marcelo Calderari , Silva Luiz Carlos da
Published: December 2022

The Communication Policy is considered an essential element in business and strategies. In this way, placing a bibliographic review as the scientific literature on communication is internalized in the scope of Information Science. Bibliometric indicators for a theme Communication Policy are presented in front of a Reference Database of Articles from Journals in Information Science (Brapci). The study situates an exploratory qualitative-quantitative research and uses precepts and bibliometrics to assess the productivity of a memory in science. The diagnosis found 152 indexed articles, of which 18 fit the parameters established in the sample. The study proves the main researchers, periods of productivity and publication vehicles on the subject. In the conclusion, it is mentioned that the Communication Policy is an indispensable construct of Information Science, since, through interdisciplinarity, an expansion of conceptions that go beyond organizational practices increasingly improve the critical look at informational mediation in the university-society-innovation context.
Solbad Hall: 70 jaar later
Authors: Verdoodt Frans-Jos
Published: December 2022

Cyriel Verschaeve was al lang voor de Tweede Wereldoorlog van oordeel dat Vlaanderen omwille van zijn Germaans karakter verbonden was met Duitsland. Die romantische visie werd niet bijgesteld door de realiteit van het nationaalsocialisme noch door de ineenstorting van het Derde Rijk. Ter dood veroordeeld in België beschouwde hij zich in zijn schuiloord te Solbad Hall, waar hij op vlucht voor de Belgische justitie onderdook, als een balling. Hij nam geen verantwoordelijkheid op voor de feiten en ontwikkelingen van de collaboratie waar hij medeverantwoordelijk voor was. Na zijn dood werd hij door medestanders vereerd als een martelaar. Zijn graf werd een bedevaartsoord bezocht door o.m. Vlaams-nationalistische jeugdbewegingen tot in 1973 de Vlaamse Militanten Orde (VMO) het lichaam van Verschaeve clandestien overbracht naar Vlaanderen met de bedoeling het bij te zetten in de crypte van de IJzertoren. Het plan mislukte doordat het voortijdig uitlekte. Mede door de bemiddeling van Rik De Gheyn, secretaris van het IJzerbedevaartcomité, kreeg Verschaeve een laatste rustplaats in Alveringem waar hij van 1911 tot aan zijn vlucht naar Duitsland in 1944 kapelaan was geweest. De VMO organiseerde nog herdenkingen aan zijn graf, maar het aura rond Verschaeve verdween door de historiografisch-wetenschappelijke visie op de persoon en zijn tijd.____________________
Solbad Hall: 70 years laterLong before the Second World War, Cyriel Verschaeve had already reached the conclusion that Flanders was inextricably conjoined with Germany because of its Germanic essence, a romantic vision that remained unchanged, even in the face of the horrors of Nazism and the collapse of the Third Reich. Sentenced to death in Belgium, Verschaeve envisioned himself as an exile in Solbad Hall, where he took shelter from the Belgian judicial system. Taking no responsibility for the facts and developments of the wartime collaboration he was instrumental in, Verschaeve became a martyr to his supporters after his death. His grave turned into a pilgrimage site which was visited by numerous Flemish-nationalist youth movements until 1973, when the VMO (Flemish Militant Order) exhumed Verschaeve’s remains and transferred it to Flanders, hoping to bury him in the Yser Tower’s crypt. The plan partly failed, but the Secretary of the Committee on the Yser Pilgrimage Rik de Gheyn’s mediation resulted in Verschaeve receiving a final resting place in Alveringem, the village where he was a chaplain from 1911 until his flight to Germany in 1944. And while the VMO continued to organize commemorations at his grave, Verschaeve’s aura had dissipated because of the growing prominence of the historical-critical vision on Verschaeve and his era.
"En vandaag kunnen wij verzekeren: Verschaeve is niet dood!" Discours en retoriek tijdens de bedevaarten naar Solbad Hall (1950-1973)
Authors: Fuhrmann Aragorn
Published: December 2022

Wat heeft het Vlaams-nationalisme met onsterfelijkheid? In de rijke historiografie van de Vlaamse beweging zijn nogal wat pagina’s gewijd aan de verering van de Grote Vlaamse Doden, een flamingantische traditie die diep in de 19de-eeuw haar oorsprong vond en in de loop van de 20ste-eeuw werd toegeëigend door radicaal-rechtse nationalisten. Deze bijdrage stelt scherp op de talige kunstgrepen en geritualiseerde ceremonies waarmee deze dodenherdenkers hun overleden helden in leven probeerden te houden. De bedevaarten naar het graf van Cyriel Verschaeve in Solbad Hall laten niet alleen zien hoe de radicale Vlaamse beweging dit overleden boegbeeld wilde instrumentaliseren voor politiek-ideologische doelen (de regeneratie van het Vlaams-nationalisme na de Tweede Wereldoorlog; de amnestie-kwestie), maar ook hoe van dit proces vaak onverwachte bijwerkingen uitgingen. Zo valt er iets voor te zeggen dat de illegale, zelfs door Vlaamsgezinde groeperingen bekritiseerde opgraving van Verschaeves stoffelijke resten door de Vlaamse Militanten Orde (VMO) in 1973 (‘Operatie Brevier’) een (ongewild) product was van het discours over diens onsterfelijkheid dat vorm kreeg tijdens de bedevaarten naar Solbad Hall. Door de kapelaan van Alveringem op systematische basis voor te stellen als de Verlosser van Vlaanderen, creëerden zijn bewonderaars en herdenkers de symbolische werkelijkheid waarin een spectaculaire en ogenschijnlijk ongerijmde daad als Operatie Brevier kon plaatsvinden als een logische handeling.________________________
“And today we can assure you: Verschaeve is not dead!” Discourse and rhetoric during the pilgrimages to Solbad Hall (1950-1973)In the rich historiography of the Flemish Movement, quite a few pages are dedicated to the worship of the ‘Great Flemish Dead’, a tradition which originated in the nineteenth century and was appropriated by radical-right nationalists during the twentieth century. This article examines the linguistic machinery and ritualised ceremonies by which the commemorators, worshippers and idolaters tried to keep their departed heroes alive. The pilgrimages to Cyriel Verschaeve’s grave in Solbad Hall not only demonstrate how the radical Flemish Movement wanted to instrumentalise this deceased figurehead for political and ideological purposes (i.e. the regeneration of Flemish nationalism after World War II; the amnesty debate), but also how this process had some unexpected side effects. This article argues that the illegal, and even by pro-Flemish organisations criticised, excavation of Verschaeve’s remains by the Vlaamse Militanten Orde (VMO) in 1973 (‘Operatie Brevier’), was an (unwanted) product of the discourse on Verschaeve’s immortality, which took root during the pilgrimages to Solbad Hall. By depicting the chaplain of Alveringem as the saviour of Flanders, his commemorators and worshippers created a symbolic reality in which a staggering and at first glance incongruous deed as Operatie Brevier could take place.
Bolnička palijativna rehabilitacijska skrb neuroloških bolesnika u Službi za produženo liječenje i palijativnu skrb Novi Marof Opće bolnice Varaždin
Authors: Moslavac Saša , Moslavac Aleksandra
Published: December 2022

Palijativna rehabilitacijska skrb dio je bolničke palijativne skrbi kojom se holističkim pristupom bolesniku, ciljanim metodama multiprofesionalnog tima, svima, pa i neurološkim bolesnicima u fazama pogoršanja kronične bolesti ili kod brzoprogresivnog neurološkog stanja nastoji pomoći u poboljšanju funkcije i smanjenju oštećenja struktura tijela, umanjiti ograničenja u aktivnostima i participaciji. Time se i u fazama bolesti kada aktivno liječenje više nije indicirano, bolesnicima omogućuje samostalnost dajući im dignitet do samog kraja života, koliko to prirodni procesi dopuštaju. Uloga specijalista fizikalne medicine i rehabilitacije i tima suradnika može biti ključna u ovim procesima.
Fibromialgija – sindrom kronične generalizirane boli – prikaz slučaja
Authors: Zahirović Nino , Schnurrer-Luke-Vrbanić Tea , Buršić Martina , Šegota Adelmo , Avancini-Dobrović Viviana
Published: December 2022

Cilj: Prikaz slučaja bolesnice s fibromialgijom koja se inicijalno prezentirala kroničnom proširenom boli te je proveden dijagnostičko-terapijski postupak. Prikaz slučaja: Bolesnica u dobi od 61 godine liječena je pri Zavodu za fizikalnu i rehabilitacijsku medicinu s reumatologijom zbog jakih kroničnih bolova u zglobovima i mišićima. Bolesnica dodatno opisuje poteškoće sa spavanjem, tegobe depresije i anksioznosti. Boluje od hipotireoze, a prethodno su na magnetskoj rezonanciji utvrđene degenerativne promjene kralježnice. Opsežnom je dijagnostičkom obradom isključena upalna reumatska bolest, neurološka bolest, paraneoplastični sindrom, neregulirana hipotireoza te kronična infekcija. Dijagnostički upitnik za fibromialgiju potvrdio je sumnju da bolesnica boluje od fibromialgije temeljem rezultata upitnika (Widespread pain index (WPI) 15; symptom severity scale (SSS) 9). Procjena umora kronične bolesti dala je izrazito loš rezultat (The Functional Assessment of Chronic Illness Therapy (FACIT-F) 15/52), što je ukazalo na lošu kvalitetu života. Provedeno je nefarmakološko liječenje koje se sastojalo od edukacije, individulane kineziterapije i fizikalno-terapijskih procedura te multimodalno farmakološko liječenje. Izborom lijekova djelovalo se na nociceptivnu i neuropatsku vrstu boli, kao i na anksioznost bolesnice s povoljnim terapijskim odgovorom. Navedenim pristupom liječenja postignuto je značajno poboljšanje tegoba sindroma fibromialgije u naše bolesnice. Zaključak: U bolesnika s proširenom kroničnom boli, kroničnim umorom i poremećajima mentalnog stanja treba posumnjati na fibromialgiju. Dijagnostičkom je obradom potrebno isključiti drugu ozbiljnu bolest. Za postavljanje dijagnoze fibromialgije koriste se dijagnostički kriteriji iz 2016. godine – American College of Rheumatology (ACR). Ovim prikazom bolesnice željeli smo podignuti svijest o ovoj bolesti koja je u svijetu prepoznata kao ozbiljan zdravstveni problem iako ponekad zanemaren i nepriznat.
Impact of Gamification on Consumers’ Favorability in Cause-Related Marketing Programs: Between-Subjects Experiments
Authors: Li Yanhe , Li Yanchen , Zhou Xiu , Ma Kunshu
Published: December 2022

Background

Successful cause-related marketing (CRM) campaigns can help companies stand out from their competitors; however, CRM may not have pleasant outcomes, even if it receives substantial investment.

Objective

This research aimed to investigate how gamified CRM projects influence consumers’ favorability.

Methods

We introduced 3 different CRM projects in 3 different studies. Every project had 2 versions according to the level of gamification, and participants were randomly assigned into these 2 groups. Additionally, we used a 2 (gamification: lower, higher) 2 (rules presentation: without visual cues, with visual cues) between-subjects design to test the moderation role of rules presentation in gamified CRM projects.

Results

In Study 1, we identified that the highly gamified CRM program induces more enjoyment (F1,139=21.11, P<.001) and higher favorability (F1,139=14.57, P<.001). Moreover, we found that enjoyment played a mediation role between gamification and favorability (P<.001) in Study 2. In addition, the results of Study 3 indicated rules presentation in a gamified CRM program can moderate the indirect effect of gamification on favorability via enjoyment (index of the moderated mediation: 95% CI –1.12 to –0.10; for rules presentation with visual cues: 95% CI 0.69 to 1.40; for rules presentation without visual cues: 95% CI 0.08 to 0.83).

Conclusions

Overall, this research contributes to the CRM literature and suggests gamification is an effective way of managing CRM campaigns.
Identifikasi dan Sosialisasi Potensi Desa di Era Informasi: PKM Multidisipliner di Dusun Gatak, Cangkringan, Yogyakarta
Authors: Dhewayani Jeanny
Published: December 2022

In this Information Age, promoting village life and its potentialities can be delivered as interesting and useful content in digital media. In the effort to empower rural communities, communication technology such as mobile phones, which are relatively inexpensive and practical, can be employed to identify village potential, especially for young people. Not only interesting for the youth, but it can also involve them in community activities and give a meaning ful and greater experience. So, the main objective of this community service program is to assist the local youth in identifying the social condition and potentialities the village has by applying a research method that is easy, accurate, and friendly. Given the limited time available, the multidisciplinary team takes the Digital Humanity approach in the form of youth training as the type of activity implemented in this program. Accordingly, to provide research experience to participants, Rapid Rural Appraisal (RRA) is taken as the primary method in undergoing the activity.

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Di Era Informasi ini, mempromosikan kehidupan desa dan potensinya dapat dihadirkan sebagai konten yang menarik dan bermanfaat di media digital. Dalam upaya pemberdayaan kehidupan masyarakat pedesaan, teknologi komunikasi seperti telepon genggam yang relatif murah dan praktis dapat digunakan untuk mengidentifikasi potensi desa, khususnya bagi generasi muda. Ponsel tidak hanya menarik bagi kaum muda, tetapi juga dapat melibatkan mereka dalam kegiatan masyarakat dan memberikan pengalaman yang lebih bermakna dan lebih besar. Jadi, secara prinsip, tujuan utama dari program pengabdian masyarakat yang dilakukan secara multidisipliner ini adalah membantu pemuda desa setempat dalam mengidentifikasi kondisi sosial dan potensi yang dimiliki desa mereka dengan menerapkan metode penelitian yang mudah, akurat, dan menyenangkan. Mengingat keterbatasan waktu yang tersedia, pelatihan pemuda dipilih sebagai jenis aktivitas yang diterapkan oleh tim dalam program ini. Oleh karena itu, untuk memberikan pengalaman penelitian lapangan kepada peserta. Rapid Rural Appraisal (RRA) dijadikan sebagai metode utama dalam pelaksanakan kegiatan.
Digitalisasi Makam Penyiar Islam Raden Mas Suryodilogo di Pamboang Sulawesi Barat
Authors: Adawiah Rabiatul , Hasyim Ashari  , Ahmad Muaffaq  , Husna  , Nasrah
Published: December 2022

Unlike the tombs of other Islamic broadcasters, the tomb of Raden Mas Suryodilogo has not received good attentions from the government and the public. The main purpose of this community service is to publish this historical site through digitization in the form of making a video and an infographic poster. This project is implemented from February to July 2022 using the Asset-based Community Development (ABCD) approach which emphasizes a community-driven element. The service team has carried out eight stages starting from team formation, training of trainers, appreciation interviews, asset mapping, observation and literature studies, FGD, making videos and posters, socialization to monitoring, and evaluation. In general, societies in Pamboang realize that they have assets and potential including religious tourism in the form of relics of Raden Mas Suryodilogo so the team did not find any obstacles when mapping assets. The community is also actively involved and willing to participate at the time of image taking and to disseminate information through the output of this PkM.

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Berbeda dengan makam tokoh penyiar Islam lainnya, makam Raden Mas Suryodilogo belum mendapat perhatian yang baik dari pemerintah dan masyarakat. Program pengabdian kepada masyarakat ini bertujuan memublikasikan situs bersejarah tersebut melalui digitalisasi berupa pembuatan video dan poster infografis. PkM ini dilaksanakan pada bulan Februari hingga Juli tahun 2022 dengan menggunakan pendekatan Asset based Community Development (ABCD) yang menekankan unsur community driven. Tim pengabdi telah melaksanakan delapan tahapan yang dimulai dari pembentukan tim, training of trainers, wawancara apresiasi, pemetaan aset, observasi dan studi pustaka, FGD, pembuatan video dan poster, sosialisasi, hingga monitoring dan evaluasi. Secara umum, masyarakat menyadari bahwa mereka memiliki aset dan potensi wisata termasuk wisata religi berupa peninggalan Raden Mas Suryodilogo sehingga tim tidak menemukan kendala pada saat pemetaan aset. Masyarakat juga terlibat aktif dan bersedia untuk berpatisipasi pada saat pengambilan gambar hingga penyebaran informasi melalui output dari PkM ini.