bluuebunny/crossref_metadata_2025 huggingface dataset:
Pelatihan Public Speaking dan Personal Branding untuk Membangun Karakter Kepemimpinan Siswa OSIS SMA Angkasa 1 Halim Perdanakusuma Jakarta
Authors: Andika Yunilis Andika , Wahyu Tri Widyastuti  , Al Farisi Salman
Published: December 2024

Public speaking and personal branding are essential skills that can open career opportunities and advance professional development for everyone, especially OSIS students. SMA Angkasa 1 Halim Perdanakusuma recognizes the importance of these skills for its students. Unfortunately, specialized training related to these topics has not yet been conducted there. To address this issue, the Community Service team from the French Language Education Program collaborated with SMA Angkasa 1 Halim Perdanakusuma to organize training in public speaking and personal branding aimed at developing the leadership character of OSIS students. This activity was conducted in-person and comprised three stages: preparation, implementation, and evaluation. A total of 33 students participated in this event, receiving both theoretical and practical instruction, along with assignments to enhance their public speaking skills and build a positive self-image. The results of the training showed positive development after the sessions, with participants demonstrating increased confidence and the ability to present material effectively using various public speaking techniques. 
 
Abstrak
Public speaking dan personal branding adalah keterampilan penting yang dapat membuka peluang karir dan memajukan perkembangan profesional bagi setiap orang, terutama siswa OSIS. SMA Angkasa 1 Halim Perdanakusuma menyadari pentingnya keterampilan tersebut bagi siswanya. Sayangnya, pelatihan khusus terkait tema tersebut belum pernah dilaksanakan di sana. Untuk mengatasi permasalahan tersebut, tim Pengabdian Kepada Masyarakat Prodi Pendidikan Bahasa Prancis bekerja sama dengan SMA Angkasa 1 Halim Perdanakusuma dalam mengadakan pelatihan public speaking dan personal branding dengan tujuan mengembangkan karakter kepemimpinan siswa OSIS. Kegiatan ini dilaksanakan secara luring dengan tiga  tahapan  yakni  persiapan, pelaksanaan,  dan  evaluasi. Sebanyak 33 siswa menjadi peserta pada kegiatan ini dengan diberikan teori dan praktik, serta penugasan untuk meningkatkan keterampilan berbicara di depan umum dan membangun citra diri yang positif. Hasil pelatihan menunjukkan perkembangan yang positif setelah pelatihan di mana peserta memiliki kepercayaan diri yang meningkat sehingga mampu menyampaikan materi dengan baik dengan menerapkan berbagai teknik public speaking.
Akuntansi dan Aplikasi Pesantren: Menuju Modernisasi Tata Kelola Pesantren
Authors: Sutrisno Catur Ragil , Al Farisi Salman , Ilmiani Amalia , Khoiri Habib , Agung Prasetya Nanda
Published: December 2024

This study uses a quantitative descriptive method to describe the phenomenon accurately without testing a specific hypothesis. This study focuses on the financial governance of Islamic boarding schools in Pekalongan Regency by involving 44 ustadz/ustadzah as respondents who were selected randomly. Primary data were collected through questionnaires. The results of the study indicate that most Islamic boarding schools still maintain traditional learning methods (salaf), and some have combined formal curriculum. Regarding financial management, most Islamic boarding schools have a simple bookkeeping system, and some have adopted a more structured accounting system supported by accounting applications or integrated information systems. These findings underline the importance of accounting training and information system development to improve Islamic boarding school accountability. There is an urgent need for Islamic boarding schools to adapt to the demands of modern governance without sacrificing their traditions.
Successful Reduction of a Dislocated Hip Joint in a Patient With Cutis Laxa From a PYCR1 Mutation
Authors: Samarah O.Q. , Abu Rumman D.H. , Ibrahim S.J. , Hamed E.K. , Obeidat D.M.
Published: December 2024

Case:

We report a successful surgical management of a teratologic hip dislocation in a 2.5-year-old girl child with cutis laxa and a positive PYCR1 gene mutation. She had characteristic facial features including triangular face with frontal bossing. Moreover, she had wrinkly skin on her limbs. At 2-year follow-up, she became an independent ambulator with stable hip joint and mild limping.

Conclusion:

The surgical principles of treating a high riding hip dislocation in patients with positive PYCR1 gene mutation should be comprehensive including open reduction, pelvic osteotomy, and femoral shortening osteotomy with derotation. Meticulous capsulorrhaphy optimizes the development and stability of the hip joint.
CONSTRUCTION OF A GOODS ELEVATOR WITH A MANUAL PULLEY SYSTEM
Authors: Yanel Karnova
Published: December 2024

Lift, atau yang sering disebut sebagai elevator, merupakan alat angkut yang biasa digunakan pada bangunan bertingkat untuk mengangkut orang atau barang. Dalam perancangan ini, tujuan utamanya adalah untuk merancang sebuah lift yang digunakan pada gedung bertingkat dua dengan ketinggian 4 meter. Latar belakang dari proyek ini adalah untuk menyediakan sistem lift yang praktis dan efisien bagi bangunan dengan kapasitas atau mesin yang tidak terlalu besar. Tujuan dari perancangan ini adalah untuk menciptakan sistem lift berbasis katrol manual yang terjangkau dan dapat diandalkan, cocok untuk bangunan bertingkat rendah. Metode yang digunakan meliputi observasi terhadap sistem lift yang sudah ada, penerapan standar perancangan yang ada, serta tinjauan pustaka yang mendalam. Berdasarkan hal tersebut, lift ini menggunakan sistem katrol manual dengan kapasitas beban maksimal 540 kg. Sangkar yang mampu menampung empat orang ditarik menggunakan enam tali tipe 8x19 dengan diameter 13 mm. Sangkar tersebut dituntun oleh rel tipe T90 dan dilengkapi dengan sistem pengaman jenis wedge untuk meningkatkan keamanan. Hasil dari perancangan ini menunjukkan bahwa sistem ini memenuhi spesifikasi yang diperlukan terkait kapasitas beban dan keselamatan, serta tetap efisien dan terjangkau untuk aplikasi yang dimaksud. Kesimpulannya, sistem lift katrol manual ini merupakan solusi yang layak dan praktis untuk bangunan kecil hingga menengah, dengan menawarkan keandalan dan keamanan dalam anggaran yang terjangkau
Collaborative Supervision: Increasing Teachers' Creativity in the Implementation of Multicultural-based Independent Curriculum
Authors: Sahudi Sahudi , Ma'arif Samsul
Published: December 2024

The study aims to describe the success of the collaborative supervision between the head of the madrasah and the teachers at five private madrasah tsanawiyah in Gresik. This research, a qualitative case study design, involved the head of the madrasah and the teachers of five private madrasah tsanawiyah. Instruments used include interviews, observations, and documentation. Data analysis techniques used are data condensation, data presentation, conclusion drawing, and verification. The research findings demonstrate the significant positive impact of collaborative supervision on teachers’ creativity and professionalism and its direct correlation with students' improved learning quality and learning outcomes. Collaborative supervision has been successful in enhancing the creativity of teachers in the implementation of a multicultural-based independent curriculum. The implications of the findings provide a strong basis for educational institutions to consider implementing more effective collaborative supervision strategies in the context of a multicultural-based independent curriculum. The importance of considering cultural and multicultural contexts is also highlighted in designing educational supervision programmes and strengthening the inclusive learning environment.
Designing Effective Online Learning Environments for Teacher Professional Development: Evidence from Indonesian In-Service Teachers
Authors: Apoko Tri Wintolo , Yatri Ika
Published: December 2024

The teacher profession education program (TPEP) within virtuality is an alternative learning program that is believed to be important for Indonesian in-service teachers nowadays and in the future as learning through digital technology is the competitiveness of the nation that needs to be continuously improved. This study aims to investigate Indonesian in-service teachers’ needs in the TPEP through online learning environments and to discover an effective design of online learning environment for TPEP in the future. The design used in this study was a mixed method with sequential explanatory design. For quantitative data, a questionnaire was distributed to the Indonesian in-service teachers attending the online TPEP over four months at a reputable private university in Indonesia, and 916 teachers completed the questionnaire. Meanwhile, the qualitative data were collected through semi-structured interview with selected Indonesia in-service teachers. The results indicate that online learning provides in-service teachers’ needs, and effective design is recommended for better professional development for in-service teachers in Indonesia. In addition, the qualitative feedbacks from participants regarding online learning environments identify several challenges. These findings suggest that the proposed design of online TPEP can be significantly implemented to meet the evolving needs of educators in an increasingly digital world.
STRATEGI KEPALA MADRASAH DALAM PENGELOLAAN BANTUAN KINERJA DAN AFIRMASI (BKBA) PENDIDIKAN PADA MADRASAH
Authors: Suratman Suratman
Published: December 2024

Pada riset ini bertjuan untuk mendeskrispkan cara kepala madrasah dalam pengelolaan bantuan kinerja dan afirmasi pendidikan. Jenis penelitian ini adalah deksriptif kualitatif dengan pendekatan fenomenologis dengan teknik analisis melakukan koleksi data, kondensasi, dispaly data dan verifikasi. Riset memperoleh hasil dimana kepala madrasah memiliki peran membimbing dan mendampingi stat dalam proses penyusunan anggaran, melakukan persetujuan atau penolakan di aplikasi jika tidak secara dengan standar nasional pendidikan, melakukan sosialiasi, monitoring dan evaluasi serta perbaikan secara. Komponen madrasah penerima kinerja memiliki kensenjangan 11,37 lebih tinggi dari pada madrasah penerima bantuan afirmasi sebesar 0,23. Madrasah penerima bantuan afirmasi memiliki kesenjangan -0, 42%, yang bersifat negative atau kekurangan beberapa komponen yang sangat memerlukan bantuan, sedangkan pada madrasah penerima bantuan kinerja sudah memiliki pengembangan komponen madrasah dan nilai evaluasi diri madrasahnya memiliki kinerja baik.
KONTRIBUSI ISTRI SEBAGAI PENCARI NAFKAH
Authors: Fajriyati Nadiya , Najib Rofiqun , Zulkarnain Rifaldi
Published: December 2024

In the sakinah family consensus, it is the wife's responsibility to take care of children and needs in the kitchen. However, with the development of the times, the roles in the family often change, and this tendency has even become a hereditary custom among the people of Wonorejo Village, Poncokusumo District, Malang Regency. Wonorejo city has a lot of potential in an industrial area, many industrial cigarette factories, spear and apple plantations are often used as a livelihood for women. Only they don't know that earning a living is the husband's duty and responsibility. This problem has become a trend in Wonorejo village, they don't understand the law of the problem, so they often do it. Therefore, it is necessary to understand women's contribution to family livelihoods from the perspective of the Syafi'i school of thought.This research adopts the empirical research type and adopts the qualitative research method. The results of this study show that the majority of women in the village of Wonorejo contribute directly to the generation of household income. Imam Syafi'i explained several livelihood indicators commonly used by men, 2 mud for the rich, 1 mud for the poor and 1.5 for the middle class. So much so that you can see in the context of women's contributions that a woman's ability to work must be based on a man's enjoyment, with a clear purpose.
DEVELOPMENT OF AN EXPERIENTIAL LEARNING MODEL BASED ON DEDICATION TO SOCIETY
Authors: Hidayah Maulida Ulfa , Ulfah Zakiyah , Kadir Marniati
Published: December 2024

Optimal learning is not only seen in the presentation of the theory in the class so that students are able to know and memorize the theories. However, depending on how the student gains direct experience and then reflects on it in the process of his graduation. Also at the college level, various forms of learning through the experience process will be more acceptable, one of which is the experiential learning model. In addition, the learning process is also developed by integrating service activities into the community. To this end, the aim of this research is to design and determine the feasibility of developing a model of experiential learning based on dedication to society in the course of teaching. The method used is the Research and Development (R&D) method with the 4D (four-D) model of Thiagarajan, i.e., defining, designing, developing, and deploying. The result is that (1) the stage of model design is structured based on the results of needs analysis, as well as the preparation of the framework and product development, which are carried out with the creation of books that include the rational development of the learning model; (2) the model of experiential learning based on dedication to society is highly qualified to be used as a model of learning both from the technical side of design, material, purpose, and motivation of learning.
DETERMINAN KINERJA KEUANGAN SYARIAH DAERAH PROVINSI SUMATERA UTARA DENGAN BELANJA MODAL SEBAGAI VARIABEL MODERATING
Authors: Agnesia Inge , Ridwan M , Batubara Maryam
Published: December 2024

This study aims to determine the effect of General Allocation Funds (DAU), Special Allocation Funds (DAK), Regional Taxes, and regional levies on Regional Sharia Financial Performance Efficiency with regional expenditure moderation variables. This research method uses a quantitative method approach with the help of the Eviews program version 9. This research uses secondary data originating from the Budget Realization Report (LRA) and the Regional Revenue and Expenditure Budget Realization Report of the District/City Government of North Sumatra Province. This research was conducted in North Sumatra Province and the time of the research was carried out in stages from October 2021 to August 2022. The results showed that (1) general allocation funds did not have a significant and negative effect on regional sharia finances, (2) regional taxes had an insignificant and negative effect on regional sharia finances, (3) regional levies have no significant and positive effect on regional sharia finances, (4) General Allocation Funds have no significant and positive effect on regional sharia finances through capital expenditure as a moderating variable, (5) special allocation funds have no significant and negative effect on regional sharia finances through capital expenditures, (6) regional taxes do not have a significant and positive effect on regional sharia finances through capital expenditures as a moderating variable, and (7) regional levies have an insignificant and positive effect on regional sharia finances through capital expenditures as a moderating variable.
PROBLEMATIKA DAN SOLUSI PENGELOLAAN WAKAF UANG PADA PERWAKILAN BADAN WAKAF INDONESIA PROVINSI KALIMANTAN SELATAN
Authors: Budiman Muh. Arief , Umar Masyithah , Hakim Budi Rahmat
Published: December 2024

Dampak pengelolaan wakaf sangatlah besar terhadap pembangunan umat, terutama jika melihat data BWI bulan Januari Tahun 2021 menyebutkan bahwa total wakaf di Indonesia mencapai nilai 180 Triliun Rupiah. Nilai wakaf yang sangat besar ini memerlukan pengelolaan yang benar dan terperinci, sehingga wakaf dapat dimanfaatkan untuk kesejahteraan umat secara optimal. Namun dalam pengelolaan dana wakaf oleh BWI tidak terlepas dari berbagai macam problematika, dalam penelitan ini terangkum pada tiga permasalahan utama yaitu permasalahan dalam perhimpunan wakaf uang, pendayagunaan wakaf uang, dan pendistribusian hasil manfaat wakaf uang. Penelitian ini bertujuan untuk memberikan solusi pada problematika pengelolaan wakaf uang pada perwakilan BWI Kalimantan Selatan. Metode yang digunakan dalam penelitian ini adalah deskriptif kualitatif, dengan jenis field research. Data yang digunakan adalah data primer dan sekunder, data primer yaitu dengan wawancara langsung kepada pihak pengelola wakaf perwakilan BWI Kalimantan Selatan dan data sekunder mengambil dari data yang diterbitkan oleh BWI. Hasil penelitian menjelaskan bahwa BWI Kalimantan Selatan dalam penghimpunan wakaf uang perlu meningkatkan sosialisasi mengenai wakaf uang pada level masyarakat umum dan level pemerintahan, dalam hal pengelolaan wakaf uang di Kalimantan Selatan pihak BWI perlu meningkatkan tingkat kompetensi sebagai nazhir sehingga dana wakaf dapat terus bertumbuh bukan malah berkurang. Adapun dalam permasalahan pendistribusian wakaf, perlu kiranya BWI meningkatkan koordinasi kepada yayasan atau lembaga yang bergerak dibidang sosial, lembaga amil zakat sehingga manfaat dari wakaf dapat terdistribusikan secara optimal.
IMPLEMENTASI KURIKULUM MERDEKA PADA PEMBELAJARAN PAI DI JENJANG SEKOLAH MENENGAH PERTAMA
Authors: Izza Aimatul , Astutik Anita Puji
Published: December 2024

Tujuan pendalaman ini merupakan untuk menganalisis implementasi silabus merdeka belajar dalam pengkajian agama islam ( PAI ) pada jenjang sekolah menengah pertama ( SMP ). Kurikulum Merdeka Belajar ( KMB ) yaitu upaya pemerintah untuk meroformasikan pembelajaran di indonesia dengan membagikan kelonggaran kepada sekolah untuk meningkatkan kurikulum yang sesuai dengan kebutuhan peserta didik.      Pendalaman ini memakai cara pendalaman kualitatif dengan pendekatan studi kasus, data disatukan melewati pengamatan, wawancara, dan dokumentasi terkait kurikulum dan pembelajaran. Responden penelitian ini terdiri dari pengajar pengkajian  agama islam ( PAI ) di sekolah menengah pertama ( SMP ) Islam Sidoarjo yang mengimplementasikan silabus merdeka belajar.      Hasil penyelidikan membagikan bahwa ini program silabus merdeka belajar  untuk studi agama islam ( PAI ) di sekolah menengah pertama ( SMP ) Islam Sidoarjo mempunyai beberapa keuntungan. Pertama, pengajar dapat menyesuaikan taktik pengkajian dengan gaya belajar siswa, sehingga mengembangkan keterlibatan dan pemahaman mereka. Kedua, pengajar dapat memilih bahan yang sesuai dengan kebutuhan siswa serta keadaan setempat, mengembangkan makna pendidikan. Ketiga, pengajar mempunyai kebebasan untuk menilai kemajuan peserta didik dengan menggunakan cara penilaian yang sesuai dengan sifat dan kebutuhan siswa.
AKUNTABILITAS PENGELOLAAN ANGGARAN DALAM PERSPEKTIF MAQASHID SHARIAH PADA DINAS SYARIAT ISLAM KABUPATEN PIDIE JAYA
Authors: Ramadhana Rizki , Albani Nasution Muhammad Syukri , Batubara Maryam
Published: December 2024

Tujuan Untuk mengetahui pengelolaan anggaran pada Dinas Syariat Islam Kabupaten Pidie Jaya, Untuk mengetahui model akuntabilitas pengelolaan anggaran pada Dinas Syariat Islam Kabupaten Pidie Jaya. Penelitian ini merupakan penelitian dengan menggunakan pendekatan kualitatif deskriptif dengan menggunakan pendekatan studi kasus. Dalam penelitian ini digunakan studi dokumenter, wawancara, observasi . Adapun Hasil penelitian sebagai berikut,   Secara keseluruhan pengelolaan anggaran pada Dinas Syariat Islam Kabupaten Pidie Jaya telah terkelola dengan baik melalui prinsip perencanaan, pengorganisasian, pelaksanaan dan pengendalian yang melibatkan seluruh pihak yang berkaitan dengan program-program yang dianggarkan oleh Dinas Syariat Islam Kabupaten Pidie Jaya. Setiap melakukan penyusunan program kerja Dinas Syariat Islam Kabupaten Pidie Jaya selalu mengikutsertakan masyarakat dalam menentukan program apa saja yang akan dilakukan oleh instansi. Model akuntabilitas anggaran pada Dinas Syariat Islam Kabupaten Pidie Jaya berfokus pada output dan outcome yang diperoleh, dimulai dari input yang berupa bukti-bukti transaksi keuangan maupun dokumentasi kegiatan yang selanjutnya diproses untuk menyusun laporan akuntabilitas. Proses akuntabilitas yang dilakukan dengan menyusun, mengklasifikasi, mengikhtisarkan, dan menyajikan bukti-bukti transaksi yang menjadi input dalam uraian laporan akuntabilitas. Output yang dihasilkan adalah Laporan Akuntabilitas yang disusun, dan Outcome yang dihasilkan adalah kinerja pelaksanaan anggaran sesuai dengan yang dialokasikan dan kepercayaan para stakeholder. Namun pada praktiknya terkadang terdapat kendala pada keterlambatan pelaporan pertanggungjawaban karena adanya dokumen yang tidak lengkap dari bidang-bidang atau dari para stakeholder yang lain. Secara umum akuntabilitas anggaran yang dilakukan oleh Dinas Syariat Islam Kabupaten Pidie Jaya telah memenuhi lima tujuan dalam konsep maqashid shariah yaitu hifdz ad-din, hifdz an-nas, hifdz al-aql, hifdz al-mal, dan hifdz an-nasb. Hanya saja, Dinas Syariat Islam perlu melakukan evaluasi sebagai perbaikan ke depan dalam pengalokasian anggaran pada program-program atau kegiatan-kegiatan yang mempunyai urgensi lebih dibanding dengan program kegiatan lainnya.
Impact of LIN7A Silencing on U87 Cell Invasion and Its Clinical Significance in Glioblastoma
Authors: Lyu Xiaojuan , Shi Yuxiang , Wang Daixu , Cao Xing , Guo Jipeng , Huang Guodong , Zhou Lin , Zhang Mengxian , Dong Zhen
Published: December 2024

Background Glioblastoma is highly aggressive and resistant to treatment, making it crucial to understand the regulatory mechanisms underlying its invasion. LIN7A, a polar protein, has been implicated in tumor cell migration and invasion, but its role in glioblastoma remains unclear. This study aimed to manipulate LIN7A gene expression in U87 cells, analyze its impact on invasion, and explore the potential mechanisms through which LIN7A regulates glioblastoma cell invasion.Methods Lentiviral vectors were used to silence the LIN7A gene in U87 cells, selecting the most effective vector. LIN7A gene transcription, protein expression and localization were analyzed using RT-qPCR, Western blotting, and immunofluorescence. U87 cell invasion was assessed via real-time cell analysis and spheroid invasion assay, while MMP-2 and MMP-9 protease activities were measured using zymography. β-catenin protein levels and localization were evaluated through Western blotting and immunofluorescence. Expression of target genes in the β-catenin pathway was also measured. An orthotopic xenograft glioblastoma model in nude mice was established by intracranial implantation of U87 cells, with tumor growth monitored using immunofluorescence analysis of brain slices. The clinical significance of LIN7A expression was confirmed by comparing its levels in core and peripheral invading areas of glioblastoma and analyzing RNASeq data and clinical information from the Clinical Proteomic Tumor Analysis Consortium (CPTAC) GBM cohort.Results Transfection of U87 cells with a lentiviral vector led to decreased LIN7A levels and altered distribution patterns. Silencing the LIN7A gene increased U87 cell proliferation and invasiveness, reduced clonal formation ability, and enhanced MMP-2 and MMP-9 protease activity. It also resulted in a slight increase in cytoplasmic β-catenin content, although not statistically significant, but a significant increase in nuclear β-catenin accumulation and transcriptional activity of target genes in the pathway. Animal studies showed that LIN7A gene silencing caused U87 cells to transition from clumpy to invasive growth mode. LIN7A expression was significantly lower in the peripheral invading area compared to the core area in clinical samples of glioblastoma. Data mining of the CPTAC-GBM cohort revealed a strong association between LIN7A gene expression and survival time.Conclusion Silencing LIN7A may promote U87 tumor cell invasion by disrupting intercellular junctions, altering cell polarity, and activating the β-catenin pathway. Further research is warranted to elucidate the role of LIN7A in glioblastoma cell invasion.
Abnormal Redox Balance at Membrane Contact Sites Causes Axonopathy in Gdap1-related Charcot-marie-tooth Disease
Authors: Palau Francesc , Cantarero Lara , Roldán Mónica , Rodríguez-Sanz María , Mathison Angela , Díaz-Osorio Yaiza , Pijuan Jordi , Frías Marcos , Urrutia Raul , Hoenicka Janet
Published: December 2024

Pathogenic variants of GDAP1 cause Charcot-Marie-Tooth disease (CMT), an inherited neuropathy characterized by axonal degeneration. GDAP1, an atypical glutathione S-transferase, localizes to the outer mitochondrial membrane (OMM), regulating this organelle's dynamics, transport, and membrane contact sites (MCSs). It has been proposed that GDAP1 functions as a cellular redox sensor. However, its precise contribution to redox homeostasis remains poorly understood, as does the possible redox regulation at mitochondrial MCSs. Given the relationship between the peroxisomal redox state and overall cellular redox balance, we investigated the role of GDAP1 in peroxisomal function and mitochondrial MCSs maintenance by using high-resolution microscopy, live cell imaging with pH-sensitive fluorescent probes, and transcriptomic and lipidomic analyses in the Gdap1-/- mice and patient-derived fibroblasts.
We demonstrate that GDAP1 deficiency disrupts mitochondria-peroxisome MCSs and leads to peroxisomal abnormalities, which are reversible upon pharmacological activation of PPARγ or glutathione supplementation. These results identify GDAP1 as a new tether of mitochondria-peroxisome MCSs that maintain peroxisomal number and integrity. The supply of glutathione (GSH-MEE) or GDAP1 overexpression suffices to rescue these MCSs. Furthermore, GDAP1 may regulate the redox state within the microdomain of mitochondrial MCSs, as suggested by decreased pH at mitochondria-lysosome contacts in patient-derived fibroblasts, highlighting the relationship between GDAP1 and redox-sensitive targets.
Finally, in vivo analysis of sciatic nerve tissue in Gdap1-/- mice revealed significant axonal structural abnormalities, including nodes of Ranvier disruption and defects in the distribution and morphology of mitochondria, lysosomes, and peroxisomes, emphasizing the importance of GDAP1 in sustaining axon integrity in the peripheral nervous system. Taken together, this study positions GDAP1 as a multifunctional protein that mediates mitochondrial interaction with cellular organelles of diverse functions, contributes to redox state sensing, and helps maintain axonal homeostasis. In addition, we identify PPAR as a novel therapeutic target, based on knowledge of the underlying pathogenetic mechanisms.
Insights from LLIN Post-Distribution Monitoring Surveys in the Dominican Republic's Malaria Transmission Foci: Implications for Quantification and Distribution Strategies
Authors: Ventura Gilda Altagracia , Santos María Yinet , Tejada Natalia , Michelen Nicole , Cruz Jose Luis , Solis Angel , Barrios Rafael , Montoya Lucia Fernández
Published: December 2024

Background: Long-lasting insecticidal nets (LLINs) have been distributed in the Dominican Republic since 2008, and they remain the main vector control intervention used to pursue malaria elimination in the country. However, LLIN performance remains unclear due to a lack of monitoring over the past decade.
Methods: We conducted a cross-sectional household survey to monitor LLIN coverage, access, use, physical integrity, washing and drying practices and the time people go to bed and wake up in the two main malaria foci of the country: Azua (4-6 months post distribution) and San Juan (one year post distribution).
Results: The percentage of sleeping spaces that could be covered with an LLIN given the LLINs present in the household was 64% in Azua and 63% in San Juan, and with any net they were 75% in Azua and 80% in San Juan. Reported LLIN retention was 88.4% in Azua and 80.9% in San Juan. The percentage of people that had access to sleeping under an LLIN was 58.8% in Azua and 65.4% in San Juan. LLIN use was 32.3% in Azua and 50.5% in San Juan. Among people with full LLIN access, use was 48.8% in Azua and 75% in San Juan. Most LLINs remained in serviceable physical condition (96.4%, 88.9%) but those with holes were not repaired. Most LLINs were washed with aggressive products (65%, 86%), at a frequency that suggests they will be washed more than twenty times in three years (52%, 73%), and dried under the sun (75%, 90%).
Conclusion: Poor washing and drying practices are prevalent in both areas, low LLIN use was observed in Azua and some LLIN coverage gaps were measured in both foci. Urgent behavioral change strategies are needed to improve LLIN care in both foci and increase LLIN use in Azua, alongside revisions to LLIN quantification methods to ensure full coverage of all sleeping spaces in use during distribution. Heterogeneities in LLINs use across foci suggest that LLIN need to be monitored in each distinct distribution area to identify individual gaps and promptly address them.
Mechanochemical Synthesis of Yttrium Oxide and Hydrogen Peroxide via Planetary Ball Milling With Nickel Catalyst: Structural, Morphological, and Particle Size Analysis
Authors: Pramono Andika Widya , Ansari Mohamed , Sagutnam Meenaloshini a/p , Saputra M. Nuraliffudin , Siregar Riki Ruli A. , Herbirowo Satrio , Holifah  , Miati  , Imaduddin Agung , Nugraha Heri , Hadiyawarman  , Rois Mahardika F. , Sulistiyo Eko , Murniati Riri , Amaliyah Fina Fitratun
Published: December 2024

This study investigates the mechanochemical synthesis of Yttrium Oxide (Y₂O₃) and Hydrogen Peroxide (H₂O₂) via planetary ball milling, with a focus on the catalytic effect of nickel. Yttrium Hydride (YH₃) was milled under a hydrogen atmosphere, both with and without a nickel catalyst, to assess the influence of various process parameters such as milling time, hydrogen pressure, and catalyst presence on the phase transformation, crystallite size, particle morphology, and particle size distribution. X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), and laser diffraction particle size analysis (PSA) were used to characterize the samples. Results show that nickel catalysis significantly enhances reaction kinetics, reduces crystallite size, and promotes uniform particle morphology compared to non-catalyzed samples. Catalyzed samples exhibited faster phase transformation from YH₃ to Y₂O₃, with a crystallite size reduction to 11.0 nm and near-complete formation of Y₂O₃ and H₂O₂. These findings demonstrate that nickel-catalyzed planetary ball milling offers an efficient and scalable route for Y₂O₃ synthesis, with potential applications in catalysis, energy storage, and environmental remediation. Further research on optimizing milling conditions and exploring other catalysts is recommended.
HAREKETLİ PROTEZ KULLANAN KLİNİK ÖĞRENCİLERİNİN HASTALARININ MEMNUNİYET DURUMU DEĞERLENDİRMESİ
Authors: Sarıkaya Işıl , Usta Kutlu İlknur , Yerliyurt Kaan , Elmas Ozan Can , Dağlar Abdullah Sait , Işık Ahmet Doğan
Published: December 2024

Amaç: Diş Hekimliği 5. Sınıf klinik öğrencilerinin hazırladıkları hareketli protezlerin kullanımı sonrası hastalarının memnuniyet düzeylerinin tespit edilmesi ve bu yolla alınacak geri bildirimler doğrultusunda protez klinik uygulama eğitimine katkı sağlanmasıdır
Gereç ve Yöntemler: Çalışma; Tokat Gaziosmanpaşa Üniversitesi Protetik Diş Tedavisi Kliniğinde yürütülmüş, 20 klinik öğrencisinin tedavi ettikleri 47 hareketli protez hastası çalışmada yer almıştır. 6 aydır hareketli protez kullanan hastalardan OHIP-14 ağız sağlığı etki profiline uygun hazırlanan formlar ile geri bildirim alınmış ve klinik öğrencileri tarafından muayeneleri yapılarak protezlerinden memnuniyetleri değerlendirilmiştir. Verilerin analizinde SPSS 27.0 paket programı kullanılarak ifadelere verilen yanıtların her düzeydeki yüzdeleri (n %) belirlenmiştir. Nitel değişkenler arasında ilişki olup olmadığını değerlendirmek için çapraz tablolardan ve Pearson ki-kare testlerinden yararlanılmıştır. p değerleri 0.05’den küçük hesaplandığında istatistiksel olarak anlamlı kabul edilmiştir.
Bulgular: Katılımcıların protezlerini kullanırken telaffuz (p = 0,002) ve tat almaları (p < 0,001) konusunda, ayrıca gerginlik hissetme durumları (p = 0,022) ve protezden bekletilerinin karşılanma durumu arasında istatistiksel olarak anlamlı farklılık tespit edilmiştir. Katılımcıların daha önce protez kullanıp kullanmamış olması ile yeni yapılan protezin beklentileri karşılaması değerlendirildiğinde 47 katılımcı arasında yüzdesel olarak anlamlı bir fark bulunamamıştır (p = 0,887).
Sonuç: Hastaların beklentilerini karşılayacak düzeyde bir protez yapılarak hastaların hayat standartları iyileştirerek stres ve gerginliği azaltılabilmektedir.
Effect of Major Mycotoxins on Public Health Through the Consumption of Cheese Products
Authors:   First Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Chaidoutis Elias Ath. , Chatzimpirou Olympia ,   First Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Migdanis Ioannis ,   Department of Gastroenterology, Faculty of Medicine, University of Thessaly, Larissa, Greece, Migdanis Athanasios ,   Department of Gastroenterology, Faculty of Medicine, University of Thessaly, Larissa, Greece, Papadakis Antonios ,   Department of Clinical Microbiology and Microbial Pathogenesis, School of Medicine, University of Crete, Heraklion, Greece, Lazaris Andreas Ch. ,   First Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Kavantzas Nikolaos ,   First Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Published: December 2024

Food safety is a key priority for public health. However, consumer demand for cheese products may expose the population to the risk of mycotoxicosis and cancer, among others. Acute mycotoxicosis and cancer are examples of linked disorders. Among the most frequent toxic agents that enter the human body through food consumption are mycotoxins. This review study highlights the significance of the impact of the most important mycotoxins on public health through the consumption of cheese products. Despite being a poor substrate for mycotoxin development, cheese products have been found to contain harmful toxins. Aflatoxin Μ1 (AFM1 ) and ochratoxin A (OTA) are the main mycotoxins in cheese products, and they are very harmful to human health. Adherence to legislative limits and the implementation of appropriate control measures by food business operators (FBOs) are considered necessary to protect consumers’ health.
An Acoustic Analysis of Chinese Indonesian Students in Pronouncing English Vowels: A Praat Study
Authors: Damanik Teguh Perdana , Rangkuti Rahmadsyah , Ganie Rohani
Published: December 2024

This research aims to describe the errors made by Chinese-Indonesian students of the English Department of the University of Sumatera Utara in pronouncing English vowels; to discuss the reason for those errors this research uses Richardâ€™s theory on causes of errors; and to overcome those errors using the phonetics transcription method and repetition drills. This research uses the Praat software to analyze the phonemes through the samplesâ€™ voice recordings. This research is qualitative and quantitative research. The data of this research are voice recordings of the samples and native speakers and the questionnaire answers of the samples. It is found that the Chinese-Indonesian students of the English Department who have passed the phonology subject still produce errors in pronouncing English vowels. It is concluded that these errors are found due to the effect of their mother tongues, namely Hokkien-Indonesian. The errors are also caused by the samplesâ€™ intralingual and developmental errors. In order to overcome those errors, this research employed the phonetic transcriptions method and repetition drills and found that the methods improve the overall values of selected English vowel phonemes.
Code Switching in Tetun Songs: The Way to Teach Language
Authors: Kardiasa I Made Dwi , Udayana I Nyoman , Aryani I Gusti Agung Istri
Published: December 2024

Nowadays, the use of language can be done through daily life conversations and in the form of works, one of which is a song. In connection with the function of language in social science, sociolinguistics was born, one of which is about code-switching. This research involves six popular songs from Timor Leste that use three language variations, namely Tetun, Indonesian, and English. As a result, three types of code-switching were found: tag switching, intra-sentential switching, and inter-sentential switching. From here, there are three functions of code-switching in these songs including proving that Tetun can be comparable to other languages, code-switching can be used to discuss certain topics, and finally, this phenomenon is also effective to show certain characteristics. The function of code-switching itself is also related to the language learning process for learners.
The Representation of Social Actors in EFL Textbooks: Systemic Functional Linguistics Perspective
Authors: Guna Stanislaus , Darong Hieronimus Canggung
Published: December 2024

Systemic Functional Linguistics (SFL) has gained popularity as a linguistic theory, especially in the field of education where it provides a useful method for examining textbooks. The goal of this study is to examine how social actors are portrayed in a particular textbook utilizing SFL framework. Textual data were gathered from a sample of the textbook, and transitivity patterns of process categories and pronoun usage were used to analyze the data. The results revealed that the pronoun "he" was primarily utilized and that the material process, which denotes physical actions, was most commonly used, depicting men as the main actors. These results imply that the texts in the textbook reflect how social actors are portrayed and represented in speech and offer an understanding of their functions, choices, agency, and relations
Trances in Perspectives of Javanese and Muslim: An Anthropological Linguistic Study
Authors: Budiman Arif , Wulandari Ari , Khristianto Khristianto
Published: December 2024

Possession is a serious health problem for Javanese and Muslims. This study aims to describe the perspective of Javanese and Muslims on a trance or a state of being possessed. This is qualitative research applying a linguistic anthropological approach. The subjects are the members of the Javanese and Muslim communities in Tulungagung. They are the individuals having experienced trance(s), their family, and the witnesses. Other important informants are the healers, shamans, and Islamic leaders (ustadz or kyai). Based on the analysis, it shows that trance for the Javanese is a disease inflicted by a certain spirit. It must be cured by a shaman with a series of rituals and offerings. For Muslims, it is a disturbance of the genie as the possessed disobeys Godâ€™s rules. Its healing is done through ruqyah by reciting particular verses from the Qur'an. The way Javanese treats a trance reflects their perspectives and thoughts as found in local wisdom: tamba teka lara lunga (the cure comes and the disease goes), meaning that every disease has its cure. For Muslims, a trance is simply an effect of the human relation to his God. A better quality in the relationship will result in a humanâ€™s better life. Conversely, a bad relationship to God will bring about a negative quality in human life. Trance is just one of them; it is believed to be evidence of the poor relationship a possessed has to God.
Challenges in Implementing the Information Gap Technique to Enhance the Indonesian EFL Students' Speaking Skills
Authors: Pinilih Murni Sekar , Sukarno Sukarno
Published: December 2024

Even though the Independent  Curriculum suggests teachers conduct speaking activities in class, the real situation is quite the opposite. Students rarely speak English in class; hence, students still lack the ability to speak English. This study aims to describe the challenges in implementing the Information Gap Technique to enhance students' speaking skills in a vocational high school located in Sleman. Employing Classroom Action Research, the research unfolds across four iterative stages: planning, action, observation, and reflection. This study used interviews, observations, and documentation as primary instruments. This is qualitative analysis with interactive model analysis and thematic analysis as data analysis. The findings illuminate several hurdles faced by both teachers and students. Teachers confront difficulties in classroom management, struggling to monitor and assess students simultaneously. Meanwhile, students encounter challenges in peer assessment and formulating questions, along with linguistic obstacles in pronunciation and grammar. The study concludes that an effective strategy to mitigate these challenges involves teachers actively circulating the classroom and engaging in peer assessment. This approach enables teachers to identify and address individual student difficulties promptly. The research suggests that while IGT proves effective in enhancing speaking skills and boosting confidence, teachers should judiciously incorporate it, considering both its advantages and drawbacks. The recommendation encourages periodic utilisation of the technique, with teachers being mindful of the need for a balanced approach that addresses the identified challenges, thereby maximising the benefits of IGT in enhancing students' speaking abilities.
ESP Teacher’s Self-Reflection: Teacher Agency and Frustration of the Enactment
Authors: Hidayati Sari
Published: December 2024

Self-reflection is an integral element of teacher professional development and a viable means for sharpening teacher knowledge and skills for subsequent pedagogic applications and improving student learning outcomes. While self-reflection is an individual professional endeavor, it is obviously tied to the professional contexts. As such, the notion of self-reflection is inherently tied to improving teachers’ professional agency. However, there is potential for frustration in the enactment of teacher agency if practitioners are not cautious of the contextual constraints within which they have to exercise their agency. For example, changes that require enactment may have wider implications for institutions of employment, institutional policies of assessment and teaching, colleagues, and stakeholders. This paper aims to get an in-depth description of a teacher’s reflection on her professional practice as an English for Specific Purposes (ESP) teacher at the university level. This study adopted a qualitative case study as the research design and collected data using a semi-structured interview with an English teacher for specific purposes in the tertiary sector in Yogyakarta, Indonesia. The findings of this single case study chartered the frustrations experienced by English teachers in enacting agency for specific purposes in Indonesian tertiary education. These are discussed in relation to the implications they have for teacher agency, professional development, English for Specific Purposes classroom practice, and future research.
The Students’ Perception in Arranging Discourse Units and Text Structure in Writing Narrative Text
Authors: Nurhayati Dwi Astuti Wahyu
Published: December 2024

This article deals with the arrangement of discourse, namely cohesive devices and structure of text in narrative text writing. The students’ perspective is also discussed in the indicated investigation. The objectives are to capture the pupils ‘point of view in arranging discourse units and constructing text structure in writing. The data were taken from fourth-semester students’ narrative text writing at UIN SATU Tulungagung, and interview results were analyzed. There are twelve texts analyzed in this study. This study was conducted using a descriptive method with a qualitative approach. The findings show that there are misuses in applying linguistics tending to unite instruments, including allusion, replacement, and omission of parts of a word or sentence, as well as combination. Then, some lexical cohesive devices are easier to understand than grammatical ones, especially repetition, hyponyms, and meronyms. However, students are confused about using synonyms and antonyms collectively. The implementation of narrative text structure was also achieved. In addition, from students’ point of view, the elements of cohesive devices need to be studied further as a lack of understanding of the devices affects their writing skills.
Testing the Cognitive Retroactive Transfer Hypothesis: Evidence from Moroccan University Readers
Authors: Atouf Noureddine , Harrizi Meriem
Published: December 2024

The extant study extrapolates the principles of the Cognitive Retroactive Transfer hypothesis, a theory of reading transfer between languages recently introduced to the literature, in an academic context. Forty-five freshmen are recruited from the English Department at the School of Arts and Humanities Ben M’sik (Hassan II University of Casablanca). The study employs a quasi-experimental design which involves two main phases: pre-intervention and post-intervention. The participants are selectively allocated to an experimental group (n=25) and a control group (n=20). The experiment measures the transferability of improved metalinguistic awareness from English (the foreign language “FL”) to Arabic (the first language “L1”). To this end, a battery of reading tests is administered in both languages before and after the intervention. Upon completing the pretest phase, the experimental group receives a three-month training, targeting core metalinguistic skills. To compare pretest and posttest scores, a multivariate analysis of variance (MANOVA) is conducted to check the groups’ overall differences across the set of reading skills before using Simple Group Contrasts (k-matrix) as a follow-up test to analyze the groups’ performance on each reading skill. The results show a positive effect of the intervention on the experimental group’s performance over all the skills except orthographic knowledge posttest scores which level off. The findings give more prominence to the CRT hypothesis which has been solely tested in children bilingual settings. The unchanged orthographic knowledge scores suggest the essential role of explicit print exposure and practice in developing spelling skills in another language. The ongoing research paper calls for adopting fine-grain and level-fitting pedagogical approaches to address reading difficulties at university levels.
The Students’ Engagement in Foreign Language Learning through ICT Incorporation
Authors: Purnawati Purnawati , Rafli Zainal , Setiadi Syamsi
Published: December 2024

In this 21st century, the incorporation of Information and Communication Technology (ICT) has become a prominent practice in various educational domains, including the learning of languages in the classroom. However, there are a small number of teachers who are not familiar with incorporating ICT in their classrooms due to numerous causes. By the given situation, this study aims to identify the disparities in students' engagement between English as a Foreign Language (EFL) classrooms that utilize Information and Communication Technology (ICT) and those that do not. Additionally, it seeks to determine the predominant and higher forms of engagement in these two types of EFL classrooms. A descriptive qualitative approach was applied in this research. To obtain the data, the authors examined the level of student involvement during teaching and learning activities in two types of classrooms: those that employed ICT (Information and Communication Technology) and those that did not. Subsequently, the acquired data was scrutinized and categorized based on the parameters of students' involvement (behavioral, cognitive, and emotional). The results indicate that both classrooms are primarily characterized by students' behavioral involvement. The class that included ICT in its teaching and learning process experienced a 9.5% increase in students' cognitive engagement. The implication of this research is to encourage teachers to incorporate ICT in the classroom so that the students’ three engagement types can be achieved better proportionally.