bluuebunny/crossref_metadata_2025 huggingface dataset:
Subclinical Atherosclerosis Progression in Low-Risk, Middle-Aged Adults: Carotid Leads Femoral in IMT Increase but Not in Plaque Formation
Authors: Szabóová Eva , Lisovszki Alexandra , Rajnič Alojz , Kolarčik Peter , Szabó Peter , Molnár Tomáš , Dekanová Lucia
Published: September 2024

This study investigated subclinical atherosclerosis progression in low-risk, middle-aged adults (N = 141; a mean age of 49.6 ± 4.7 years) using a 5-year ultrasound follow-up. We compared the involvement of the carotid and femoral arteries. Methods: Clinical data, risk factors, carotid/femoral intima-media thickness (IMT), and plaque presence were analyzed. Results: Cardiovascular risk factors and scores increased significantly at follow-up. Both carotid and femoral mean IMT increased (p < 0.001). While plaque prevalence rose and was similar in both arteries (carotid: 4.8% to 17.9%, femoral: 3.6% to 17.7%, p < 0.001 for both), the progression of plaque burden was greater in femorals. Notably, the carotid mean IMT demonstrated a faster yearly progression rate compared to the mean femoral IMT. The prevalence of pathological nomogram-based mean IMT right or left was higher in the carotids (52.9% to 78.8%, p < 0.001) compared to femorals (23.2% to 44.7%, p < 0.001), with a significant increase at the end of follow-up in both territories. Conclusions: This study demonstrates significant subclinical atherosclerosis progression in low-risk, middle-aged adults over 5 years. Carotid arteries showed a faster progression rate of mean IMT and a higher prevalence of pathological nomogram-based mean IMT compared to the femoral arteries. However, plaque burden was similar in both territories, with greater progression in femorals. Identifying carotid and femoral atherosclerosis burden may be a valuable tool for risk stratification in this population.
Cardiovascular Risk in Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review
Authors: Sá-Sousa Ana , Rodrigues Cidália , Jácome Cristina , Cardoso João , Fortuna Inês , Guimarães Miguel , Pinto Paula , Sarmento Pedro Morais , Baptista Rui
Published: September 2024

Background/Objectives: A comprehensive and up-to-date review on cardiovascular disease (CVD) risk in patients with COPD is needed. Therefore, we aimed to systematically review the risk of a range of CVD in patients with COPD. Methods: We searched three databases (Pubmed, Web of Science, SCOPUS) from inception to September 2023 using terms related to COPD and CVD. Observational studies were included if they (1) were conducted in adults with a diagnosis of COPD based on the GOLD criteria, spirometry, physician diagnosis, or review of electronic health records; (2) reported the risk of CVD, namely of myocardial infarction (MI), ischaemic heart disease (IHD), atrial fibrillation (AF), heart failure, cerebrovascular disease, pulmonary hypertension, and peripheral vascular disease, compared with a control population using a measure of risk. A narrative synthesis was used. Results: Twenty-four studies from 2015 to 2023, mainly from Europe (n = 17), were included. A total of 3,485,392 patients with COPD (43.5–76.0% male; 63.9–73.5 yrs) and 31,480,333 (40.0–55.4% male, 49.3–70.0 yrs) controls were included. A higher risk of CVD in patients with COPD was evident regarding overall CVD, MI, IHD, heart failure, and angina. Higher risks of arrhythmia and AF, stroke, sudden cardiac death/arrest, pulmonary embolism, pulmonary hypertension, and peripheral vascular disease were also found, although based on a small amount of evidence. Conclusions: Patients with COPD have a higher risk of CVD than the general population or matched controls. This review underscores the need for vigilant and close monitoring of cardiovascular risk in individuals with COPD to inform more precise preventive strategies and targeted interventions to enhance their overall management.
Oral Health and Quality of Life in People with Autism Spectrum Disorder
Authors: Fallea Antonio , Vetri Luigi , L’Episcopo Simona , Bartolone Massimiliano , Zingale Marinella , Di Fatta Eleonora , d’Albenzio Gabriella , Buono Serafino , Roccella Michele , Elia Maurizio , Costanza Carola
Published: September 2024

This article delves into the intricate relationship between oral health, quality of life, and behavioral characteristics in individuals with autism spectrum disorder (ASD). Background/Objectives: Autism has been associated with various challenges, and this study seeks to elucidate the impact of ASD on oral health outcomes and overall well-being. The research focuses on assessing overall oral health by evaluating various parameters, such as the condition of lips, tongue, gums and tissues, natural teeth, dentures, oral hygiene, and dental pain in individuals with ASD. Additionally, the study explores the influence of age, sex, and certain variables, like basic daily living skills on oral health practices, aiming to identify potential correlations between these factors and oral health outcomes. Methods: We employed standardized instruments to quantitatively measure and analyze the impact of oral health status on the overall quality of life experienced by individuals with ASD. Results: The study found a statistically significant positive association between oral health, measured by the Oral Health Assessment Tool (OHAT), and quality of life, as indicated by EuroQol 5-Dimensions Youth version (EQ-5D-Y) total scores (β = 0.13045, p = 0.00271). This suggests that better oral health is linked to higher quality of life. When adjusting for age and sex in a multiple linear regression model, the association remained significant but with a slightly reduced effect size (β = 0.10536, p = 0.0167). Age also showed a marginally significant positive association with quality-of-life scores. ANOVA results indicated that participants with advanced oral health status reported significantly higher quality-of-life scores than those with poorer oral health (p = 0.00246). The study also found that intelligence quotient (IQ) does not substantially influence dental health status, while the “Autonomy” subscale of the EQ-5D-Y is positively related to the OHAT. Conclusions: Unhealthy oral conditions significantly impact the overall quality of life in individuals with ASD. Therefore, it is crucial to include regular dental assessments and treatments in therapeutic protocols for patients with ASD.
A Critical Appraisal of Reporting in Randomized Controlled Trials Investigating Osteopathic Manipulative Treatment: A Meta-Research Study
Authors: Zambonin Mazzoleni Gabriele , Bergna Andrea , Buffone Francesca , Sacchi Andrea , Misseroni Serena , Tramontano Marco , Dal Farra Fulvio
Published: September 2024

Background/Objectives: In osteopathy, it becomes necessary to produce high-quality evidence to demonstrate its effectiveness. The aim of this meta-research study is to assess the reporting quality of RCTs published in the osteopathic field. Methods: The protocol was preliminarily registered on the “Open Science Framework (OSF)” website. For reporting, we considered the PRISMA 2020 checklist. We included all the RCTs, published between 2011 and 2023, investigating the effectiveness of Osteopathic Manipulative Treatment (OMT) in any possible condition. The search process was conducted on four major biomedical databases including PubMed, Central, Scopus and Embase. A data extraction form was implemented to collect all relevant information. The completeness of reporting was calculated as the percentage of adherence to the CONSORT checklist; the Cochrane ROB 2 tool was considered to assess the risk of bias (RoB) in the following five major domains: randomization (D1), interventions (D2), missing data (D3), outcome measurement (D4), selective reporting (D5). Results: A total of 131 studies were included and the overall adherence was 57%, with the worst section being “other information” (42%). Studies with a lower RoB showed higher adherence to the CONSORT. The “results” section presented the highest differences as follows: D1 (−36.7%), D2 (−27.2%), D3 (−21.5%) and D5 (−25.5%). Significant correlations were also found between the preliminary protocol registration, higher journal quartile, publication in hybrid journals and the completeness of reporting (β: 19.22, CI: 14.45–24.00, p < 0.001; β: 5.41; CI: 2.80–8.02, p ≤ 0.001; β: 5.64, CI: 1.06–10.23, p = 0.016, respectively). Conclusions: The adherence to the CONSORT checklist in osteopathic RCTs is lacking. An association was found between a lower completeness of reporting and a higher RoB, a good journal ranking, publication in hybrid journals and a prospective protocol registration. Journals and authors should adopt all the strategies to adhere to reporting guidelines to guarantee generalization of the results arising from RCTs.
Travel-Related Cutaneous Myiasis: A Case Report
Authors: Mendoza Alessa Z. , Borna Sahar , Ho Olivia A. , Waldorf James C.
Published: September 2024

Background: Human myiasis, the infestation of tissues by dipterous larvae, commonly manifests as painful, raised skin lesions, particularly in tropical regions such as Latin America, where Dermatobia hominis (the human botfly) is a frequent cause. With increased international travel, cases of travel-related myiasis have become more prevalent, necessitating awareness among healthcare providers in non-endemic regions. Methods: We present a case of cutaneous myiasis in a 69-year-old male who returned to the United States from Belize. The patient exhibited a painful skin lesion on his right knee, initially suspected to be an insect bite. The diagnosis was confirmed through ultrasound imaging, which revealed the presence of a subcutaneous larva. Conservative larva removal efforts failed, leading to surgical extraction of the larva. Results: The surgical intervention successfully removed the larva in its entirety, with the wound healing well after the procedure. Pathological examination confirmed the larva as Dermatobia hominis. The patient experienced a satisfactory recovery, with no complications observed during follow-up. Conclusions: This case underscores the importance of considering myiasis in the differential diagnosis of patients presenting with painful skin lesions following travel to tropical regions. As globalization increases, healthcare providers should be vigilant in recognizing and appropriately treating travel-related diseases such as myiasis to ensure prompt and effective care.
Placental Sonomorphologic Appearance and Fetomaternal Outcome in Fontan Circulation
Authors: Jost Elena , Gembruch Ulrich , Schneider Martin , Gieselmann Andrea , La Rosée Karl , Momcilovic Diana , Vokuhl Christian , Kosian Philipp , Ayub Tiyasha H. , Merz Waltraut M.
Published: September 2024

Objectives: Pregnancies in women with Fontan circulation are on the rise, and they are known to imply high maternal and fetal complication rates. The altered hemodynamic profile of univentricular circulation affects placental development and function. This study describes placental sonomorphologic appearance and Doppler examinations and correlates these to histopathologic findings and pregnancy outcomes in women with Fontan circulation. Methods: A single-center retrospective analysis of pregnancies in women with Fontan circulation was conducted between 2018 and 2023. Maternal characteristics and obstetric and neonatal outcomes were recorded. Serial ultrasound examinations including placental sonomorphologic appearance and Doppler studies were assessed. Macroscopic and histopathologic findings of the placentas were reviewed. Results: Six live births from six women with Fontan physiology were available for analysis. Prematurity occurred in 83% (5/6 cases) and fetal growth restriction and bleeding events in 66% (4/6 cases) each. All but one placenta showed similar sonomorphologic abnormalities starting during the late second trimester, such as thickened globular shape, inhomogeneous echotexture, and hypoechoic lakes, resulting in a jelly-like appearance. Uteroplacental blood flow indices were within normal range in all women. The corresponding histopathologic findings were non-specific and consisted of intervillous and subchorionic fibrin deposition, villous atrophy, hypoplasia, or fibrosis. Conclusions: Obstetric and perinatal complication rates in pregnancies of women with Fontan circulation are high. Thus, predictors are urgently needed. Our results suggest that serial ultrasound examinations with increased awareness of the placental appearance and its development, linked to the Doppler sonographic results of the uteroplacental and fetomaternal circulation, may be suitable for the early identification of cases prone to complications.
Intraoral Scanning Enables Virtual-Splint-Based Non-Invasive Registration Protocol for Maxillofacial Surgical Navigation
Authors: Wilkat Max , Saigo Leonardo , Kübler Norbert , Rana Majeed , Schrader Felix
Published: September 2024

Background/Objectives: Surgical navigation has advanced maxillofacial surgery since the 1990s, bringing benefits for various indications. Traditional registration methods use fiducial markers that are either invasively bone-anchored or attached to a dental vacuum splint and offer high accuracy but necessitate additional imaging with increased radiation exposure. We propose a novel, non-invasive registration protocol using a CAD/CAM dental splint based on high-resolution intraoral scans. Methods: The effectiveness of this method was experimentally evaluated with an ex vivo 3D-printed skull measuring the target registration error (TRE). Surgical application is demonstrated in two clinical cases. Results: In the ex vivo model, the new CAD/CAM-splint-based method achieved a mean TRE across the whole facial skull of 0.97 ± 0.29 mm, which was comparable to traditional techniques like using bone-anchored screws (1.02 ± 0.23 mm) and dental vacuum splints (1.01 ± 0.33 mm), while dental anatomical landmarks showed a lower accuracy with a mean TRE of 1.84 ± 0.44 mm. Multifactorial ANOVA confirmed significant differences in TRE based on the registration method and the navigated level of the facial skull (p < 0.001). In clinical applications, the presented method demonstrated high accuracy for both midfacial and mandibular surgeries. Conclusions: Our results suggest that this non-invasive CAD/CAM-splint-based method is a viable alternative to traditional fiducial marker techniques, with the potential for broad application in maxillofacial surgery. This approach retains high accuracy while eliminating the need for supplementary imaging and reduces patient radiation exposure. Further clinical trials are necessary to confirm these findings and optimize splint design for enhanced navigational accuracy.
Comparative Prognostic Value of Coronary Calcium Score and Perivascular Fat Attenuation Index in Coronary Artery Disease
Authors: Savo Maria Teresa , De Amicis Morena , Cozac Dan Alexandru , Cordoni Gabriele , Corradin Simone , Cozza Elena , Amato Filippo , Lassandro Eleonora , Da Pozzo Stefano , Tansella Donatella , Di Paolantonio Diana , Baroni Maria Maddalena , Di Stefano Antonio , De Conti Giorgio , Motta Raffaella , Pergola Valeria
Published: September 2024

Coronary artery disease (CAD) is the leading global cause of mortality, accounting for approximately 30% of all deaths. It is primarily characterized by the accumulation of atherosclerotic plaques within the coronary arteries, leading to reduced blood flow to the heart muscle. Early detection of atherosclerotic plaques is crucial to prevent major adverse cardiac events. Notably, recent studies have shown that 15% of myocardial infarctions occur in patients with non-obstructive CAD, underscoring the importance of comprehensive plaque assessment beyond merely identifying obstructive lesions. Cardiac Computed Tomography Angiography (CCTA) has emerged as a cost-effective and efficient technique for excluding obstructive CAD, particularly in patients with a low-to-intermediate clinical likelihood of the disease. Recent advancements in CCTA technology, such as improved resolution and reduced scan times, have mitigated many technical challenges, allowing for precise quantification and characterization of both calcified and non-calcified atherosclerotic plaques. This review focuses on two critical physiological aspects of atherosclerotic plaques: the burden of calcifications, assessed via the coronary artery calcium score (CACs), and perivascular fat attenuation index (pFAI), an emerging marker of vascular inflammation. The CACs, obtained through non-contrast CT scans, quantifies calcified plaque burden and is widely used to stratify cardiovascular risk, particularly in asymptomatic patients. Despite its prognostic value, the CACs does not provide information on non-calcified plaques or inflammatory status. In contrast, the pFAI, derived from CCTA, serves as an indirect marker of coronary inflammation and has shown potential in predicting adverse cardiac events. Combining both CACs and pFAI assessment could offer a comprehensive risk stratification approach, integrating the established calcification burden with novel inflammatory markers to enhance CAD prevention and management strategies.
Linking Intra-Articular Inflammatory Biomarkers with Peripheral and Central Sensitization in Late-Stage Knee Osteoarthritis Pain: A Pilot Study
Authors: Puts Sofie , Njemini Rose , Bilterys Thomas , Lefeber Nina , Scheerlinck Thierry , Nijs Jo , Beckwée David , Bautmans Ivan
Published: September 2024

Background/Objectives: To investigate if intra-articular biomarkers relate to peripheral and central sensitization in patients with late-stage knee osteoarthritis (KOA). Methods: A total of 17 (6M, 11F) patients (aged 69 ± 10 years) were assessed for peripheral (pressure pain thresholds (PPT)) and central (temporal summation (TS) and conditioned pain modulation (CPM)) sensitization the day before total knee arthroplasty. Synovial fluid was collected during surgery and assayed for IL-6, IL-8, IL-10, TNF-α, CXCL-10, BDNF, NGF, CCL2, CCL5, VEGF, IL-1RI, MMP-1, MMP-7, IL-1β, and CXCL-9. Associations of biomarkers and their combinations reflecting chronic (CXCL-9) and acute ((CCL2×CXCL-10)/IL-10)) inflammation, cartilage degeneration (MMP-1×MMP-7), and neurotrophy (NGF×BDNF) with PPT, TS, and CPM were analyzed by bivariate correlations and by multiple linear regression analyses corrected for BMI, sex, and age. Results: The medial joint line and the superior medial joint region showed the lowest PPT. Higher acute inflammation related significantly to worse pressure tenderness at the superior medial joint region (R2 = 0.642; p = 0.010). Cartilage degeneration and chronic inflammation were associated with both absolute (R2 = 0.827; p = 0.001) and relative CPM (R2 = 0.882; p < 0.001). Acute inflammation and neurotrophy were related to relative TS at the m. tibialis anterior (R2 = 0.728; p = 0.02). Conclusions: This study demonstrates that increased levels of intra-articular biomarkers of acute inflammation are related to peripheral sensitization and that biomarkers of cartilage degeneration and chronic inflammation are associated with central sensitization. These results may be a stepping-stone toward a better understanding of the working mechanism of peripheral and central sensitization in KOA pain and the development of more targeted therapeutic interventions.
Assessing Microstructural, Biomechanical, and Biocompatible Properties of TiNb Alloys for Potential Use as Load-Bearing Implants
Authors: Karakurt Eyyup Murat , Huang Yan , Cetin Yuksel , Incesu Alper , Demirtas Huseyin , Kaya Mehmet , Yildizhan Yasemin , Tosun Merve , Akbas Gulsah
Published: September 2024

Titanium-Niobium (TiNb) alloys are commonly employed in a number of implantable devices, yet concerns exist regarding their use in implantology owing to the biomechanical mismatch between the implant and the host tissue. Therefore, to balance the mechanical performance of the load-bearing implant with bone, TiNb alloys with differing porosities were fabricated by powder metallurgy combined with spacer material. Microstructures and phase constituents were characterized with energy dispersive spectroscopy (EDS), scanning electron microscopy (SEM), and X-ray diffraction (XRD). The mechanical properties were tested by uniaxial compression, and the corrosion performance was determined via a potentiodynamic polarization experiment. To evaluate a highly matched potential implant with the host, biocompatibilities such as cell viability and proliferation rate, fibronectin adsorption, plasmid-DNA interaction, and an SEM micrograph showing the cell morphology were examined in detail. The results showed that the alloys displayed open and closed pores with a uniform pore size and distribution, which allowed for cell adherence and other cellular activities. The alloys with low porosity displayed compressive strength between 618 MPa and 1295 MPa, while the alloys with high porosity showed significantly lower strength, ranging from 48 MPa to 331 MPa. The biological evaluation of the alloys demonstrated good cell attachment and proliferation rates.
Discrete Element Study on Mechanical Properties of MICP-Treated Sand under Triaxial Compression
Authors: Xie Liquan , Zhou Jingsong , Shen Li , Ji Yifan , Li Wenlin , Cheng Yaofei
Published: September 2024

Microbial-induced calcium carbonate precipitation (MICP) has attracted much attention as a promising technology for soil improvement in the infrastructures of marine engineering. This paper introduces a novel numerical sample preparation technique for MICP-treated sand, with particular attention paid to the distribution patterns of calcium carbonate, including contact cementing, bridging, and grain coating. The effect of calcium carbonate content (CCC) on the deformation and failure mechanism is studied at macroscopic and granular scales. The findings show that a small amount of calcium carbonate can quickly increase the strength of sand. The strength improvement and deformation control of MICP technology are better than those of traditional compaction treatment. As the calcium carbonate content increases, the mechanical coordination number of the sand also increases, indicating a more stable microstructure of the sand phase. In the contact bonding mode, initial failure occurs as shear failure between sand and calcium carbonate. In the bridge mode, initial failure manifests as shear failure between calcium carbonate particles. In the coating mode, initial failure occurs as tensile failure between sand and calcium carbonate. Calcium carbonate contributes to a reduction in both sliding and rolling movements among sand particles.
Comparison of Summer Coastal Currents off the East Coast of Korea in 2021 and 2022
Authors: Lee Seung-Woo , Pak Gyundo , Park Jae-Hyoung , Lee Su-Chan , Jeong Jin-Yong , Noh Suyun
Published: September 2024

This study investigates the variability of coastal currents off the east coast of Korea, specifically in the Wangdolcho area of the East/Japan Sea, from June 2021 to October 2022. The observations revealed significant fluctuations in depth-averaged current velocity, with a peak of 0.81 m/s in August 2021 and a minimum of −0.05 m/s in August 2022. These year-to-year variations highlight the complex dynamics of coastal currents influenced by regional wind patterns and mesoscale eddies. In the summer of 2021, the development of offshore eddies, coupled with variable alongshore wind stress, led to increased current velocities and alternating upwelling and downwelling conditions, resulting in abrupt changes in current intensity. Conversely, in the summer of 2022, the negative vorticity in the Korea Strait and negative wind stress curl along the coast likely caused the East Korean Warm Current to shift further offshore, resulting in a weakened southward flow along the coast. This study emphasizes the need for long-term monitoring to better understand the coastal current dynamics and their environmental impacts. The anticipated completion of the Wangdolcho Ocean Research Station is expected to greatly improve monitoring capabilities, providing continuous and comprehensive data that will enhance our understanding of coastal currents and their broader impacts on the marine environment.
Tidal Impacts on Zooplankton Dynamics in a Major Ocean-Lagoon Channel: Insights from a 25-Hour Intensive Survey in the Cotonou Channel, Benin
Authors: Akodogbo Hervé Hotèkpo , Dossou-Sognon Fridolin Ubald , Ouinsou François Talomonwo , Avocegan Thalasse Tchémangnihodé , Kouglo Junior Patric , Okpeitcha Olaègbè Victor , Assogba Arnaud , Sohou Zacharie , Morel Yves , Chaigneau Alexis
Published: September 2024

This study investigates the effects of tidal cycles on the zooplankton community within the Cotonou Channel, an important waterway connecting the large Nokoué Lagoon to the Atlantic Ocean in Benin. From the determination of zooplankton composition from 25-hour samples collected in July 2020, alpha diversity indices and abundance were assessed, while relationships between biotic and abiotic parameters were analyzed through Pearson correlation, analysis of variance, and principal component analysis. A total of 66 zooplankton taxa were identified, with rotifers exhibiting the highest species richness (35 taxa), while copepods dominated in abundance (71%). Zooplankton abundance varied significantly, ranging from 2 to 95 ind L−1 depending on the tidal phase. A negative correlation was found between species richness (r = −0.51, p < 0.01) and increasing salinity (3–37), indicating that higher salinity reduced diversity (r = 0.06, p > 0.05). Resilient species like Synchaeta bicornis persisted despite salinity changes. The tidal cycle structurally altered the zooplankton community, with abundance and diversity peaking at different phases, notably higher at high tide (15 ind L−1.) These initial findings underscore the complex interactions between tidal dynamics and estuarine biodiversity, suggesting the need for further research across different tidal and seasonal conditions to inform effective management and conservation efforts.
A Deformable and Multi-Scale Network with Self-Attentive Feature Fusion for SAR Ship Classification
Authors: Chen Peng , Zhou Hui , Li Ying , Liu Bingxin , Liu Peng
Published: September 2024

The identification of ships in Synthetic Aperture Radar (SAR) imagery is critical for effective maritime surveillance. The advent of deep learning has significantly improved the accuracy of SAR ship classification and recognition. However, distinguishing features between different ship categories in SAR images remains a challenge, particularly as the number of categories increases. The key to achieving high recognition accuracy lies in effectively extracting and utilizing discriminative features. To address this, we propose DCN-MSFF-TR, a novel recognition model inspired by the Transformer encoder–decoder architecture. Our approach integrates a deformable convolutional module (DCN) within the backbone network to enhance feature extraction. Additionally, we introduce multi-scale self-attention processing from the Transformer into the feature hierarchy and fuse these representations at appropriate levels using a feature pyramid strategy. This enables each layer to leverage both its own information and synthesized features from other layers, enhancing feature representation. Extensive evaluations on the OpenSARShip-3-Complex and OpenSARShip-6-Complex datasets demonstrate the effectiveness of our method. DCN-MSFF-TR achieves average recognition accuracies of 78.1% and 66.7% on the three-class and six-class datasets, respectively, outperforming existing recognition models and showcasing its superior capability in accurately identifying ship categories in SAR images.
The Cryptochrome CryA Regulates Lipid Droplet Accumulation, Conidiation, and Trap Formation via Responses to Light in Arthrobotrys oligospora
Authors: Shen Yanmei , Yang Xuewei , Zhu Meichen , Duan Shipeng , Liu Qianqian , Yang Jinkui
Published: September 2024

Light is a key environmental factor affecting conidiation in filamentous fungi. The cryptochrome/photolyase CryA, a blue-light receptor, is involved in fungal development. In the present study, a homologous CryA (AoCryA) was identified from the widely occurring nematode-trapping (NT) fungus Arthrobotrys oligospora, and its roles in the mycelial growth and development of A. oligospora were characterized using gene knockout, phenotypic comparison, staining technique, and metabolome analysis. The inactivation of AocryA caused a substantial decrease in spore yields in dark conditions but did not affect spore yields in the wild-type (WT) and ∆AocryA mutant strains in light conditions. Corresponding to the decrease in spore production, the transcription of sporulation-related genes was also significantly downregulated in dark conditions. Contrarily, the ∆AocryA mutants showed a substantial increase in trap formation in dark conditions, while the trap production and nematode-trapping abilities of the WT and mutant strains significantly decreased in light conditions. In addition, lipid droplet accumulation increased in the ∆AocryA mutant in dark conditions, and the mutants showed an increased tolerance to sorbitol, while light contributed to the synthesis of carotenoids. Finally, AoCryA was found to affect secondary metabolic processes. These results reveal, for the first time, the function of a homologous cryptochrome in NT fungi.
Using an Ensemble of Machine Learning Algorithms to Predict Economic Recession
Authors: Omolo Leakey , Nguyen Nguyet
Published: September 2024

The COVID-19 pandemic and the current wars in some countries have put incredible pressure on the global economy. Challenges for the U.S. include not only economic factors, major disruptions, and reorganizations of supply chains, but also those of national security and global geopolitics. This unprecedented situation makes predicting economic crises for the coming years crucial yet challenging. In this paper, we propose a method based on various machine learning models to predict the probability of a recession for the U.S. economy in the next year. We collect the U.S.’s monthly macroeconomic indicators and recession data from January 1983 to December 2023 to predict the probability of an economic recession in 2024. The performance of the individual economic indicator for the coming year was predicted separately, and then all of the predicted indicators were used to forecast a possible economic recession. Our results showed that the U.S. will face a high probability of being in a recession period in the last quarter of 2024.
The Role of Diversified Geo-Information Technologies in Urban Governance: A Literature Review
Authors: Li Ying , Lai Yani , Lin Yanliu
Published: September 2024

Global urbanization has made urban governance a crucial aspect of sustainable urban development. While geo-information technologies have emerged as indispensable tools for effective urban governance, a comprehensive analysis of their application in this context remains lacking. This study seeks to review and assess the pivotal role of geo-information technologies in the field of urban governance. A total of 219 related studies were used for bibliometric analysis and key content analysis. Planning Support Systems (PSSs), Participatory Geographic Information Systems (PGISs), Building Information Modeling (BIM), and City Information Modeling (CIM) are identified as the main information technologies progressively employed across diverse stages of urban planning and construction over recent decades. These advancements have propelled the digital and intelligent management of urban areas, yielding significant benefits such as enhanced visualization, informed decision-making, and increased opportunities for citizen participation. However, a noticeable disparity between supply and demand during the application process arises from a lack of transdisciplinary cooperation. This study sheds light on the existing literature and offers policy implications and recommendations for more effective utilization of geo-information technologies in future spatial governance.
Synergistic Development Pathways for National Parks and Local Regions: Shared Socioeconomic Pathway Scenario Forecasting and Optimization
Authors: Sun Danni , Zhong Fanglei , Nie Ying , Ma Yulian , Liu Yusong , Liu Yang
Published: September 2024

National parks play a crucial role in protecting ecosystems and biodiversity while facing challenges in balancing nature conservation and economic development. However, because of the difficulty in the unified simulation of natural protection functions and regional socioeconomic development, there is a lack of integrated prediction research on the comprehensive development pathways of national parks and their surrounding areas. This study adopts the Shared Socioeconomic Pathway (SSP) framework that links climate change research with socioeconomic development paths, taking China’s first national park—Sanjiangyuan National Park—region as an example, to conduct research on the synergistic development path of regional socioeconomic development and national parks. The model design includes five typical paths to cover a wide range of socioeconomic development possibilities. These paths are based on different assumptions, including factors such as population growth, economic development, energy use, technological progress, and policy choices. By applying scenario planning methods, optimal development pathways are identified based on environmental, economic, and social priorities. The results show that GDP growth is fastest under the sustainable development and fossil fuel development pathways. By 2050, the population difference under different pathways will approach 100,000, and the GDP gap will be close to CNY 200 billion. This study provides valuable insights for the planning, decision-making, and management of Sanjiangyuan and similar national parks and their surrounding areas, contributing to the promotion of sustainable ecological and economic development of national parks and their regions.
Comprehensive Ecological Functional Zoning: A Data-Driven Approach for Sustainable Land Use and Environmental Management—A Case Study in Shenzhen, China
Authors: Li Yu , Zhang Fenghao , Li Ruifan , Yu Hongbing , Chen Yao , Yu Han
Published: September 2024

A comprehensive approach to ecological functional zoning in the Shenzhen region of China is presented in this study. Through the integration of advanced geospatial analysis tools, multiple data sources, and sophisticated statistical techniques, different ecological functions have been identified and categorized based on a comprehensive set of indicators and spatial analysis techniques. The three-level zoning framework established in this study offers policymakers, urban planners, and environmental managers a nuanced understanding of the region’s environmental characteristics, and highlights areas of ecological significance that warrant special attention and protection. It has been demonstrated that the data-driven approach to ecological functional zoning is effective in delineating distinct ecological zones within the study area. This study’s findings carry significant implications for future land use planning, conservation efforts, and sustainable development practices in the Shenzhen region. In essence, this study contributes to the broader discourse on ecological planning and environmental management by providing a systematic and data-driven approach to delineating ecological functional zones in urbanizing regions.
Euterpe Oleracea Martius (Açaí) Extract and Resistance Exercise Modulate Cardiac Parameters of Hypertensive Rats
Authors: de Meireles Pilar Barbosa , de Miranda Denise Coutinho , de Moura Anselmo Gomes , Ribeiro Willian Cruz , Oliveira Ângela Quinelato , Leite Luciano Bernardes , Forte Pedro , Ribeiro Lúcia , Encarnação Samuel G. , Guimarães-Ervilha Luiz Otávio , Machado-Neves Mariana , e Dias Mariana Moura , Campos Iasmim Xisto , Reis Emily Correna Carlo , Peluzio Maria do Carmo Gouveia , Natali Antônio José , Lavorato Victor Neiva
Published: September 2024

Background: The study evaluated the effects of resistance exercise training and açaí supplementation on cardiac parameters in hypertensive animals. Methods: For this study, rats from the Wistar and SHR lines (spontaneously hypertensive rats) were used. The animals were divided into 5 groups: Wistar Control (C); Control Hypertensive (H); Trained Hypertensive (HT); Hypertensive and Supplemented with Açaí (HA); and Hypertensive Trained and Supplemented with Açaí (HAT). Resistance exercise training was carried out through climbing. The supplemented groups received 3 g of açaí/kg of body mass. The animals’ systolic blood pressure (SBP), body mass, and physical test were measured at the beginning and end of the intervention. At the end, an echocardiographic analysis was performed. Histological analysis and oxidative stress of the LV were performed. Results: It was found that hypertensive animals showed an increase in SBP, and the treatments reduced this parameter. The trained groups achieved higher values of maximum carrying load. Hypertension increased the dimension of the left ventricular free wall in diastole and reduced ejection and shortening fractions. The trained groups showed improvement in ejection and shortening fractions. The H group increased the proportion of extracellular matrix and reduced the proportion of cells, with the HAT group attenuating this change. Cell diameter was greater in group H, and all treatments reduced this parameter. Hypertension increased the concentration of malondialdehyde and decreased catalase activity in LV. The treatments managed to mitigate this damage. Conclusions: It is concluded that the treatments managed to generate positive cardiovascular adaptations, and their combination enhanced these effects.
Evaluation of a Commercial MoS2 Dry Film Lubricant for Space Applications
Authors: Johnson Duval A. , Gori Marcello , Vellore Azhar , Clough Andrew J. , Sitzman Scott D. , Lince Jeffrey R. , Martini Ashlie
Published: September 2024

Molybdenum disulfide coatings, particularly Microseal 200-1, have been extensively used as dry film lubricants for actuating mechanisms in space applications. Although Microseal 200-1 has historically been a popular choice for space missions, recent assessments indicate a need for reexamination. This study evaluates sliding friction in air and dry gaseous nitrogen atmospheres at ambient temperatures with both linear reciprocating and rotary unidirectional tribo-tests. Measurements are performed for Microseal 200-1 applied on substrates and surface treatments commonly used in aerospace components, particularly stainless steel and a titanium alloy. Our findings indicate that the friction of stainless steel balls sliding on Microseal 200-1-coated disks is significantly influenced by the environment as well as the disk substrate material. The average friction coefficient ranges from 0.12 to 0.48 in air and from 0.04 to 0.41 in dry gaseous nitrogen, and the amount of friction is consistently much higher for the Microseal 200-1 on the stainless steel than on the titanium alloy. Microscopy and surface analyses, including scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray fluorescence, of the coatings on stainless steel substrates reveals that the coatings are sparse and relatively thin, likely a key factor contributing to their high friction. This insight underscores the substrate dependence of this widely used coating and highlights the importance of detailed tribological testing in accurately assessing the tribological performance of commercial dry film lubricants, a key step towards improving the reliability and effectiveness of actuating mechanisms for space applications.
Biomass-Derived Carbons as Friction Reducing Additives for Lubricants: Tribological Properties of Biochars and Activated Carbons Obtained from Sugar Cane Bagasse
Authors: Molza Audrey , Bilas Philippe , Nomède-Martyr Nadiège , Césaire Thierry , Yacou Christelle , Gaspard Sarra , Thomas Philippe
Published: September 2024

Activated carbons are commonly used for adsorption/depollution applications, but only a few studies are related to their lubricating properties. In order to investigate a new family of friction reducers, the tribological properties of biochars and derived activated carbons obtained from sugar cane bagasse are investigated. Activated carbons are obtained from either a physical (steam water) or chemical (with phosphoric acid) activation process. The tribological tests show that the activated carbons present very low friction coefficients, close to 0.08. The correlation of textural and tribological investigations shows that the specific surface area of the compounds as well as the microporous and mesoporous domain extensions are key parameters to optimize the friction reduction properties of activated carbons. The friction properties of the compounds are improved if the mesoporous domain extension is above 40% of the total porous volume. This study shows that local biomass waste valorization is possible and that sugar cane bagasse-derived activated carbons appear as interesting new friction reduction additives for lubricants.
An Experimental Study on the Thermal Performance of a Heat Sink Filled with Porous Aluminum Skeleton/Paraffin Composite Phase Change Material
Authors: Huang Shufeng , Hu Zhihan , Chen Zhixin , Yang Dayong , Huang Weili , Zhang Bin
Published: September 2024

Organic phase change material is an ideal solution to solve the heat dissipation problem of electronic devices. However, its low thermal conductivity limits its application. To solve this problem, a new porous aluminum skeleton/paraffin composite phase change material (AS-PCM) was prepared. The effects of porosity and porous aluminum skeletons on temperature control performance were explored. The experimental results show that the addition of AS significantly improves the thermal conductivity of organic PCM, and the thermal conductivity of AS-PCM is 32.3–59.6 times higher than that of pure paraffin. In addition, the temperature difference in AS-PCM with 75% porosity is 1–2 °C lower than that of AS-PCM with 85%, and 5–8 °C lower than that of AS-PCM with 95% porosity. The skeleton structure has an impact on the temperature control performance. The Mcc porous aluminum skeleton/paraffin composite phase change material (MAS-PCM) yields the best thermal performance compared with the Fcc porous aluminum skeleton/paraffin composite phase change material (FAS-PCM). The temperature control time of the MAS-PCM heat sink is increased by 5.3–50.8% relative to the FAS-PCM heat sink. The research results provide a novel approach for improving the thermal conductivity of PCMs.
Green Synthesis of Hexagonal-like ZnO Nanoparticles Modified with Phytochemicals of Clove (Syzygium aromaticum) and Thymus capitatus Extracts: Enhanced Antibacterial, Antifungal, and Antioxidant Activities
Authors: Haiouani Kheira , Hegazy Sherif , Alsaeedi Huda , Bechelany Mikhael , Barhoum Ahmed
Published: September 2024

The green synthesis of ZnO NPs is becoming increasingly valued for its cost-effectiveness and environmental benefits. This study successfully synthesized hexagonal ZnO NPs using a combination of clove (Syzygium aromaticum) and Thymus capitatus extracts. The use of both extracts significantly improved the antibacterial and antioxidant properties of the ZnO NPs. By optimizing synthesis conditions, including ZnCl2 and extract concentrations, hexagonal wurtzite ZnO NPs were produced at room temperature with only drying at 80 °C without high-temperature annealing. The synthesized ZnO NPs exhibited a hexagonal morphology with an average particle size of 160 nm and a crystallite size of 30 nm. Energy-dispersive X-ray spectroscopy (SEM-EDX) confirmed the elemental composition of the ZnO NPs, showing a high carbon content (63.9 wt.%), reflecting the presence of phytochemicals from the extracts coated the ZnO NPs surface. The UV–Vis spectrum revealed an absorption peak at 370 nm and a bandgap energy of 2.8 eV due to lattice defects caused by organic impurities. The ZnO NPs demonstrated exceptional antioxidant activity, with a DPPH radical scavenging rate of 95.2%. They also exhibited strong antibacterial activity against both Gram-positive and Gram-negative bacteria, with inhibition zones of 25 mm against Bacillus subtilis, 26 mm against Escherichia coli, 24 mm against Salmonella typhimurium, 22 mm against Klebsiella pneumoniae, 21 mm against Staphylococcus aureus, 20 mm against Staphylococcus hominis, and 18 mm against Bacillus subtilis at 200 ppm. Furthermore, significant antifungal activity was observed against Candida albicans, with an inhibition zone of 35 mm at the same concentration. These findings underscore the effectiveness of using combined plant extracts for producing ZnO NPs with controlled morphology and enhanced biological properties, highlighting their potential for various biomedical applications.
Characterization of the Alkali and Hydrolysis Resistance of Polymer-Impregnated, Alkali-Resistant Glass Filaments
Authors: Kempis Florian , Orlowsky Jeanette
Published: September 2024

The aim of this series of tests was to characterize the alkali and water resistance of alkali-resistant (durability) glass filaments, which were optimized with two non-vulcanized formulations based on co-polymerizing styrene-butadiene rubbers (CemFil-SBR1 and CemFil-SBR2). Furthermore, it was assessed which of the two polymer-impregnated multifilament yarns is the better alternative for use in cementitious binders. For this purpose, the impregnated multifilament yarns were chemically conditioned for up to twelve months at temperatures of 23 and 50 °C in 2.5 percent sodium hydroxide solution and 2.5 percent potassium hydroxide solution as well as in 3 percent salt and distilled water. The samples were then subjected to material science tests. The liquid absorption capacities and the changes in the mass of the composite materials were determined at different times during conditioning. The load-bearing capacity of the samples was also tested using uniaxial fiber strand tensile tests. The durability of the polymer-impregnated multifilament yarns was described in detail in conjunction with scanning electron microscopy images and nominal cross-section determinations. The test liquids caused a reduction in strength during the storage period, which was accelerated by increased temperatures. The reduction in strength is mainly due to glass corrosion of the filaments. Glass corrosion is delayed due to the good impregnation quality, which fundamentally improves the durability of the yarns. The results of the durability tests show that the polymer-impregnated multifilament yarns CemFil-SBR2 are probably more suitable for use in cementitious binders, as they have better alkali and hydrolysis resistance.
Advancements in Polyethylene Oxide (PEO)–Active Filler Composite Polymer Electrolytes for Lithium-Ion Batteries: A Comprehensive Review and Prospects
Authors: Junoh Hazlina , Awang Nuha , Zakria Hazirah Syahirah , Zainuddin Nurul Amira Shazwani , Nordin Nik Abdul Hadi Md , Suhaimin Nuor Sariyan , Enoki Tomoya , Uno Takahiro , Kubo Masataka
Published: September 2024

Polyethylene oxide (PEO) has become a highly sought−after polymer electrolyte for lithium−ion batteries (LIBs) due to its high ionic conductivity, strong mechanical properties, and broad electrochemical stability range. However, its usefulness is hindered by its limited ionic conductivity at typical temperatures (<60 °C). Many researchers have delved into the integration of active fillers into the PEO matrix to improve the ionic conductivity and overall efficiency of composite polymer electrolytes (CPEs) for LIBs. This review delves deeply into the latest developments and insights in CPEs for LIBs, focusing on the role of PEO–active filler composites. It explores the impact of different types and morphologies of active fillers on the electrochemical behavior of CPEs. Additionally, it explores the mechanisms that contribute to the improved ionic conductivity and Li−ion transport in PEO−based CPEs. This paper also emphasizes the present obstacles and prospects in the advancement of CPEs containing PEO–active filler composites for LIBs. It serves as a valuable reference for scientists and engineers engaged in the domain of advanced energy storage systems, offering insights for the forthcoming development and enhancement of CPEs to achieve superior performance in LIBs.