bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table 2 from PLZF, a Tumor Suppressor Genetically Lost in Metastatic Castration-Resistant Prostate Cancer, Is a Mediator of Resistance to Androgen Deprivation Therapy
Authors: Hsieh Chen-Lin , Botta Ginevra , Gao Shuai , Li Tiantian , Van Allen Eliezer M. , Treacy Daniel J. , Cai Changmeng , He Housheng Hansen , Sweeney Christopher J. , Brown Myles , Balk Steven P. , Nelson Peter S. , Garraway Levi A. , Kantoff Philip W.
Published: April 2023

Supplementary Table 2. PLZF Cistrome analysis
Supplemental Figure 5 from A Systematic Analysis Reveals Heterogeneous Changes in the Endocytic Activities of Cancer Cells
Authors: Elkin Sarah R. , Bendris Nawal , Reis Carlos R. , Zhou Yunyun , Xie Yang , Huffman Kenneth E. , Minna John D. , Schmid Sandra L.
Published: April 2023

Supplemental Figure 5: Relationship between endocytic activity and cancer cell properties.
Supplemental Figure 4 from A Systematic Analysis Reveals Heterogeneous Changes in the Endocytic Activities of Cancer Cells
Authors: Elkin Sarah R. , Bendris Nawal , Reis Carlos R. , Zhou Yunyun , Xie Yang , Huffman Kenneth E. , Minna John D. , Schmid Sandra L.
Published: April 2023

Supplemental Figure 4: Relationship between endocytic activity and proliferation.
Suppl Figure 1 from PLZF, a Tumor Suppressor Genetically Lost in Metastatic Castration-Resistant Prostate Cancer, Is a Mediator of Resistance to Androgen Deprivation Therapy
Authors: Hsieh Chen-Lin , Botta Ginevra , Gao Shuai , Li Tiantian , Van Allen Eliezer M. , Treacy Daniel J. , Cai Changmeng , He Housheng Hansen , Sweeney Christopher J. , Brown Myles , Balk Steven P. , Nelson Peter S. , Garraway Levi A. , Kantoff Philip W.
Published: April 2023

Suppl Figure 1. AR cistrome analysis identifies androgen-activated genes
Supplement Table 1 from A Systematic Analysis Reveals Heterogeneous Changes in the Endocytic Activities of Cancer Cells
Authors: Elkin Sarah R. , Bendris Nawal , Reis Carlos R. , Zhou Yunyun , Xie Yang , Huffman Kenneth E. , Minna John D. , Schmid Sandra L.
Published: April 2023

Supplement Table 1: Rates of uptake at 5 minutes for each endocytic pathway with standard deviation (STDV) in 29 NSCLC cell lines
Supplementary Methods and References from Kinome-wide Functional Screen Identifies Role of PLK1 in Hormone-Independent, ER-Positive Breast Cancer
Authors: Bhola Neil E. , Jansen Valerie M. , Bafna Sangeeta , Giltnane Jennifer M. , Balko Justin M. , Estrada Mónica V. , Meszoely Ingrid , Mayer Ingrid , Abramson Vandana , Ye Fei , Sanders Melinda , Dugger Teresa C. , Allen Eliezer V. , Arteaga Carlos L.
Published: April 2023

Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplemental Figure Legends from A TDO2-AhR Signaling Axis Facilitates Anoikis Resistance and Metastasis in Triple-Negative Breast Cancer
Authors: D'Amato Nicholas C. , Rogers Thomas J. , Gordon Michael A. , Greene Lisa I. , Cochrane Dawn R. , Spoelstra Nicole S. , Nemkov Travis G. , D'Alessandro Angelo , Hansen Kirk C. , Richer Jennifer K.
Published: April 2023

Legends for Supplemental Figures S1-S7.
Supplementary Figure S5 from Kinome-wide Functional Screen Identifies Role of PLK1 in Hormone-Independent, ER-Positive Breast Cancer
Authors: Bhola Neil E. , Jansen Valerie M. , Bafna Sangeeta , Giltnane Jennifer M. , Balko Justin M. , Estrada Mónica V. , Meszoely Ingrid , Mayer Ingrid , Abramson Vandana , Ye Fei , Sanders Melinda , Dugger Teresa C. , Allen Eliezer V. , Arteaga Carlos L.
Published: April 2023

Supplementary Figure S5. PLK1 targeting decreases the expression of ER signaling genes.
Supplementary Figure 2 from STAT3 Inhibition Enhances the Therapeutic Efficacy of Immunogenic Chemotherapy by Stimulating Type 1 Interferon Production by Cancer Cells
Authors: Yang Heng , Yamazaki Takahiro , Pietrocola Federico , Zhou Heng , Zitvogel Laurence , Ma Yuting , Kroemer Guido
Published: April 2023

Supplementary Figure 2. The role of STAT3 in autophagy induction and the release of ATP and HMGB1.
Supplementary Figure S4 from Kinome-wide Functional Screen Identifies Role of PLK1 in Hormone-Independent, ER-Positive Breast Cancer
Authors: Bhola Neil E. , Jansen Valerie M. , Bafna Sangeeta , Giltnane Jennifer M. , Balko Justin M. , Estrada Mónica V. , Meszoely Ingrid , Mayer Ingrid , Abramson Vandana , Ye Fei , Sanders Melinda , Dugger Teresa C. , Allen Eliezer V. , Arteaga Carlos L.
Published: April 2023

Supplementary Figure S4. Treatment with volasertib abrogates cell growth and induces apoptosis.
Supplemental Figure Legends from STAT3 Inhibition Enhances the Therapeutic Efficacy of Immunogenic Chemotherapy by Stimulating Type 1 Interferon Production by Cancer Cells
Authors: Yang Heng , Yamazaki Takahiro , Pietrocola Federico , Zhou Heng , Zitvogel Laurence , Ma Yuting , Kroemer Guido
Published: April 2023

Supplemental Figure Legends. Supplemental Figure Legends
Supplementary Tables S1-S4 from MMP16 Mediates a Proteolytic Switch to Promote Cell–Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma
Authors: Tatti Olga , Gucciardo Erika , Pekkonen Pirita , Holopainen Tanja , Louhimo Riku , Repo Pauliina , Maliniemi Pilvi , Lohi Jouko , Rantanen Ville , Hautaniemi Sampsa , Alitalo Kari , Ranki Annamari , Ojala Päivi M. , Keski-Oja Jorma , Lehti Kaisa
Published: April 2023

Supplementary Tables S1-S4. MMPs which are significantly over-expressed in melanoma cell lines compared to the mean expression of all cancer cell lines in the datasets with over 15 melanoma cell lines (S1); Outlier analysis of MMP16 copy number gain or over-expression using DNA and mRNA datasets containing more than 20 clinical melanoma samples (S2); MMP mRNA expression, LVI and clinicopathological data of human melanoma tumors (S3); S100B staining coverage, lymphatic and blood vessel densities of human melanoma tumors (S4)
Table S1 from PLK1 and HOTAIR Accelerate Proteasomal Degradation of SUZ12 and ZNF198 during Hepatitis B Virus–Induced Liver Carcinogenesis
Authors: Zhang Hao , Diab Ahmed , Fan Huitao , Mani Saravana Kumar Kailasam , Hullinger Ronald , Merle Philippe , Andrisani Ourania
Published: April 2023

Table S1: Quantification of immunoblots (Fig. 5A)
Supplementary Data from PLK1 and HOTAIR Accelerate Proteasomal Degradation of SUZ12 and ZNF198 during Hepatitis B Virus–Induced Liver Carcinogenesis
Authors: Zhang Hao , Diab Ahmed , Fan Huitao , Mani Saravana Kumar Kailasam , Hullinger Ronald , Merle Philippe , Andrisani Ourania
Published: April 2023

Supplementary Data
Figure S1 from PLK1 and HOTAIR Accelerate Proteasomal Degradation of SUZ12 and ZNF198 during Hepatitis B Virus–Induced Liver Carcinogenesis
Authors: Zhang Hao , Diab Ahmed , Fan Huitao , Mani Saravana Kumar Kailasam , Hullinger Ronald , Merle Philippe , Andrisani Ourania
Published: April 2023

Figure S1: Ubiquitination assays of SUZ12 and ZNF198 mutants
Supplementary Movie 3 from Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma
Authors: Doçi Colleen L. , Mikelis Constantinos M. , Lionakis Michail S. , Molinolo Alfredo A. , Gutkind J. Silvio
Published: April 2023

Supplementary Movies 3-4. SEMA3F induces rapid collapse of COS-7 cells transfected with NRP2 and Plexin A3 (SEMA3F).
Supplementary Movie 1 from Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma
Authors: Doçi Colleen L. , Mikelis Constantinos M. , Lionakis Michail S. , Molinolo Alfredo A. , Gutkind J. Silvio
Published: April 2023

Supplementary Movies 1. SEMA3F induces rapid collapse of LECs (Control).
Supplemental Figure 6 from Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma
Authors: Doçi Colleen L. , Mikelis Constantinos M. , Lionakis Michail S. , Molinolo Alfredo A. , Gutkind J. Silvio
Published: April 2023

Supplementary Figure 6. Doxycycline induction of the rtTA3 tetracycline-dependent transactivating complex alone had no effect on tumor growth.
Supplementary Table S3 from Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations
Authors: Sawai Yugo , Kodama Yuzo , Shimizu Takahiro , Ota Yuji , Maruno Takahisa , Eso Yuji , Kurita Akira , Shiokawa Masahiro , Tsuji Yoshihisa , Uza Norimitsu , Matsumoto Yuko , Masui Toshihiko , Uemoto Shinji , Marusawa Hiroyuki , Chiba Tsutomu
Published: April 2023

Summary of whole exome sequencing.
Supplemental Figure 2 from Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma
Authors: Doçi Colleen L. , Mikelis Constantinos M. , Lionakis Michail S. , Molinolo Alfredo A. , Gutkind J. Silvio
Published: April 2023

Supplementary Figure 2. CD31 and podoplanin stain vascular structures in head and neck tissue cores.
Supplementary Material and Methods from Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations
Authors: Sawai Yugo , Kodama Yuzo , Shimizu Takahiro , Ota Yuji , Maruno Takahisa , Eso Yuji , Kurita Akira , Shiokawa Masahiro , Tsuji Yoshihisa , Uza Norimitsu , Matsumoto Yuko , Masui Toshihiko , Uemoto Shinji , Marusawa Hiroyuki , Chiba Tsutomu
Published: April 2023

Material and Methods of Whole exome sequencing.
Supplemental Figure Legend from Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations
Authors: Sawai Yugo , Kodama Yuzo , Shimizu Takahiro , Ota Yuji , Maruno Takahisa , Eso Yuji , Kurita Akira , Shiokawa Masahiro , Tsuji Yoshihisa , Uza Norimitsu , Matsumoto Yuko , Masui Toshihiko , Uemoto Shinji , Marusawa Hiroyuki , Chiba Tsutomu
Published: April 2023

Supplemental Figure Legend
Supplemental Figure 4 from Paracrine Effect of NRG1 and HGF Drives Resistance to MEK Inhibitors in Metastatic Uveal Melanoma
Authors: Cheng Hanyin , Terai Mizue , Kageyama Ken , Ozaki Shinji , McCue Peter A. , Sato Takami , Aplin Andrew E.
Published: April 2023

Supplementary Figure 4: Expression of ErbB family proteins in UM cells.
Supplementary Methods from Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated Macrophages
Authors: Frankenberger Casey , Rabe Daniel , Bainer Russell , Sankarasharma Devipriya , Chada Kiran , Krausz Thomas , Gilad Yoav , Becker Lev , Rosner Marsha Rich
Published: April 2023

Supplementary Methods
Supplementary Figure S1 from Targeting the miR-221–222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple Myeloma
Authors: Zhao Jian-Jun , Chu Zhang-Bo , Hu Yu , Lin Jianhong , Wang Zhongqiu , Jiang Meng , Chen Ming , Wang Xujun , Kang Yue , Zhou Yangsheng , Chonghaile Triona Ni , Johncilla Melanie E. , Tai Yu-Tzu , Cheng Jin Q. , Letai Antony , Munshi Nikhil C. , Anderson Kenneth C. , Carrasco Ruben D.
Published: April 2023

Supplementary Figure S1. Western blot evidence of GR and PUMA downregulation in MM1R cells as compared with MM1S cells.
Supplementary Figures 1 - 9, Tables 1 - 6 from Identification of Prognostic Groups in High-Grade Serous Ovarian Cancer Treated with Platinum–Taxane Chemotherapy
Authors: Chen Ping , Huhtinen Kaisa , Kaipio Katja , Mikkonen Piia , Aittomäki Viljami , Lindell Rony , Hynninen Johanna , Auranen Annika , Grénman Seija , Lehtonen Rainer , Carpén Olli , Hautaniemi Sampsa
Published: April 2023

Supplementary Figure S1. Outcome of PSFinder. Supplementary Figure S2. Kaplan-Meier survival curves. Supplementary Figure S3. Kaplan-Meier survival curves on time to progression in month. Supplementary Figure S4. Expression boxplot of validated transcript markers. Supplementary Figure S5. Promoter methylation changes. Supplementary Figure S6. Expression of genes affected by promoter hyper- and hypo- methylation. Supplementary Figure S7. DNMT3B expression. Supplementary Figure S8. Decitabine treatment result. Supplementary Figure S9. Kaplan-Meier survival curves on overall survival time. Tables Supplementary Table S1. PSFinder identified 61 transcripts at isoform-level for Poor I, Poor II and Good prognostic patient characterization. Supplementary Table S2. PSFinder identified 32 genes at gene-level for Poor I, Poor II and Good prognostic patient characterization. Supplementary Table S3. CpG loci with promoter hypermethylation (N=32) and hypomethylation (N=1) in Poor I patients. Supplementary Table S4. Primers and probes used in Taqman qRT-PCR. Supplementary Table S5. PSFinder identified subgroups and BRCA1/2 mutation status in patients from the TCGA discovery set. Supplementary Table S6. LPS predicted subgroups and BRCA1/2 mutation status in patients from the TCGA validation set.
Supplementary Figure Legends from Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer
Authors: Schneider Lina S. , von Schwarzenberg Karin , Lehr Thorsten , Ulrich Melanie , Kubisch-Dohmen Rebekka , Liebl Johanna , Trauner Dirk , Menche Dirk , Vollmar Angelika M.
Published: April 2023

Supplementary Figure Legends. Legend for Supplementary Figures S1-S7.
Supplementary Figure 4 from TUBB3/βIII-Tubulin Acts through the PTEN/AKT Signaling Axis to Promote Tumorigenesis and Anoikis Resistance in Non–Small Cell Lung Cancer
Authors: McCarroll Joshua A. , Gan Pei Pei , Erlich Rafael B. , Liu Marjorie , Dwarte Tanya , Sagnella Sharon S. , Akerfeldt Mia C. , Yang Lu , Parker Amelia L. , Chang Melissa H. , Shum Michael S. , Byrne Frances L. , Kavallaris Maria
Published: April 2023

Validation of proteins found to be differentially expressed in H460 ÃŽÂ²III-tubulin shRNA expressing cells.
Supplementary Figure 1 from TUBB3/βIII-Tubulin Acts through the PTEN/AKT Signaling Axis to Promote Tumorigenesis and Anoikis Resistance in Non–Small Cell Lung Cancer
Authors: McCarroll Joshua A. , Gan Pei Pei , Erlich Rafael B. , Liu Marjorie , Dwarte Tanya , Sagnella Sharon S. , Akerfeldt Mia C. , Yang Lu , Parker Amelia L. , Chang Melissa H. , Shum Michael S. , Byrne Frances L. , Kavallaris Maria
Published: April 2023

2D-DIGE experimental design.
Supplemental Figure Legends from Enhanced Chemokine Receptor Recycling and Impaired S1P1 Expression Promote Leukemic Cell Infiltration of Lymph Nodes in Chronic Lymphocytic Leukemia
Authors: Patrussi Laura , Capitani Nagaja , Martini Veronica , Pizzi Marco , Trimarco Valentina , Frezzato Federica , Marino Filippo , Semenzato Gianpietro , Trentin Livio , Baldari Cosima T.
Published: April 2023

Supplemental Figure Legends from Enhanced Chemokine Receptor Recycling and Impaired S1P1 Expression Promote Leukemic Cell Infiltration of Lymph Nodes in Chronic Lymphocytic Leukemia
Supplementary Table S2 from Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations
Authors: Jacob Leni S. , Vanharanta Sakari , Obenauf Anna C. , Pirun Mono , Viale Agnes , Socci Nicholas D. , Massagué Joan
Published: April 2023

Supplementary Table S2. Mean target coverage for each sample sequence is listed.
Supplementary Table S3 from Discovery and Validation of Biomarkers That Distinguish Mucinous and Nonmucinous Pancreatic Cysts
Authors: Park Jisook , Yun Hwan Sic , Lee Kwang Hyuck , Lee Kyu Taek , Lee Jong Kyun , Lee Soo-Youn
Published: April 2023

The biomarker candidates previously reported in pancreatic cyst fluids.
Supplementary Figure S1 from Discovery and Validation of Biomarkers That Distinguish Mucinous and Nonmucinous Pancreatic Cysts
Authors: Park Jisook , Yun Hwan Sic , Lee Kwang Hyuck , Lee Kyu Taek , Lee Jong Kyun , Lee Soo-Youn
Published: April 2023

A flow chart of study subjects and abbreviations of study groups.
Supplementary material from Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue
Authors: Kennedy Brendan F. , McLaughlin Robert A. , Kennedy Kelsey M. , Chin Lixin , Wijesinghe Philip , Curatolo Andrea , Tien Alan , Ronald Maxine , Latham Bruce , Saunders Christobel M. , Sampson David D.
Published: April 2023

Mechanisms of tissue deformation in OCME
Supplemental Tables 1 - 2 from Grade-Dependent Metabolic Reprogramming in Kidney Cancer Revealed by Combined Proteomics and Metabolomics Analysis
Authors: Wettersten Hiromi I. , Hakimi A. Ari , Morin Dexter , Bianchi Cristina , Johnstone Megan E. , Donohoe Dallas R. , Trott Josephine F. , Aboud Omran Abu , Stirdivant Steven , Neri Bruce , Wolfert Robert , Stewart Benjamin , Perego Roberto , Hsieh James J. , Weiss Robert H.
Published: April 2023

Absolute values and statistics for quantitative acylcarnitine data. Absolute values and statistics for quantitative GSH and GSSG data.
Supplementary Methods and References from Definition of Prostaglandin E2–EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth
Authors: Ma Xiaojun , Aoki Tomohiro , Tsuruyama Tatsuaki , Narumiya Shuh
Published: April 2023

Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplemental Figure S4 from Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase Inhibitors by Multimodality Molecular Imaging in Living Subjects
Authors: Chan C.T. , Qi J. , Smith W. , Paranol R. , Mazitschek R. , West N. , Reeves R. , Chiosis G. , Schreiber S.L. , Bradner J.E. , Paulmurugan R. , Gambhir S.S.
Published: April 2023

Supplemental Figure S4. Up-regulation of HDAC biomarkers (p21waf1 and acetylated H3), Hsp70 and NRL-p23 fusion reporter in cells treated with lead HDAC inhibitors.
Supplemental Figure S2 from Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase Inhibitors by Multimodality Molecular Imaging in Living Subjects
Authors: Chan C.T. , Qi J. , Smith W. , Paranol R. , Mazitschek R. , West N. , Reeves R. , Chiosis G. , Schreiber S.L. , Bradner J.E. , Paulmurugan R. , Gambhir S.S.
Published: April 2023

Supplemental Figure S2. 17-DMAG enhanced the effect of Tubacin on inhibition of Hsp90(α/β)/p23 interactions.
Supplemental Figure Legends from The Estrogen Receptor Cofactor SPEN Functions as a Tumor Suppressor and Candidate Biomarker of Drug Responsiveness in Hormone-Dependent Breast Cancers
Authors: Légaré Stéphanie , Cavallone Luca , Mamo Aline , Chabot Catherine , Sirois Isabelle , Magliocco Anthony , Klimowicz Alexander , Tonin Patricia N. , Buchanan Marguerite , Keilty Dana , Hassan Saima , Laperrière David , Mader Sylvie , Aleynikova Olga , Basik Mark
Published: April 2023

Legends for Supplemental Figures S1-S8.
Supplementary Methods from CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus
Authors: Russell Mike R. , Penikis Annalise , Oldridge Derek A. , Alvarez-Dominguez Juan R. , McDaniel Lee , Diamond Maura , Padovan Olivia , Raman Pichai , Li Yimei , Wei Jun S. , Zhang Shile , Gnanchandran Janahan , Seeger Robert , Asgharzadeh Shahab , Khan Javed , Diskin Sharon J. , Maris John M. , Cole Kristina A.
Published: April 2023

Supplementary Methods
Supplementary Table 2 from High-Frequency Targetable EGFR Mutations in Sinonasal Squamous Cell Carcinomas Arising from Inverted Sinonasal Papilloma
Authors: Udager Aaron M. , Rolland Delphine C.M. , McHugh Jonathan B. , Betz Bryan L. , Murga-Zamalloa Carlos , Carey Thomas E. , Marentette Lawrence J. , Hermsen Mario A. , DuRoss Kathleen E. , Lim Megan S. , Elenitoba-Johnson Kojo S.J. , Brown Noah A.
Published: April 2023

Sinonasal Squamous Cell Carcinoma Clinical and Genotypic Data.
Supplementary Table S2 from Adaptive Responses to Dasatinib-Treated Lung Squamous Cell Cancer Cells Harboring DDR2 Mutations
Authors: Bai Yun , Kim Jae-Young , Watters January M. , Fang Bin , Kinose Fumi , Song Lanxi , Koomen John M. , Teer Jamie K. , Fisher Kate , Chen Yian Ann , Rix Uwe , Haura Eric B.
Published: April 2023

Supplementary Table S2. Dasatinib-regulated pY peptides after QC and storey q-value <0.2 cut off (207, 254 pY peptides in H2286 and HCC366, respectively).
Supplementary Table S1 from Adaptive Responses to Dasatinib-Treated Lung Squamous Cell Cancer Cells Harboring DDR2 Mutations
Authors: Bai Yun , Kim Jae-Young , Watters January M. , Fang Bin , Kinose Fumi , Song Lanxi , Koomen John M. , Teer Jamie K. , Fisher Kate , Chen Yian Ann , Rix Uwe , Haura Eric B.
Published: April 2023

Supplementary Table S1. pY peptides identified by phosphoproteomics in two DDR2 mutation cell line treated with or without 500 nM dasatinib for 3 hour (543, 636 pY peptides in H2286 and HCC366, respectively).
Supplementary Methods from Adaptive Responses to Dasatinib-Treated Lung Squamous Cell Cancer Cells Harboring DDR2 Mutations
Authors: Bai Yun , Kim Jae-Young , Watters January M. , Fang Bin , Kinose Fumi , Song Lanxi , Koomen John M. , Teer Jamie K. , Fisher Kate , Chen Yian Ann , Rix Uwe , Haura Eric B.
Published: April 2023

Supplementary Methods. Description of additional methods and procedures used in the study.
Supplementary Figures 1-8 from CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer
Authors: Karakasheva Tatiana A. , Waldron Todd J. , Eruslanov Evgeniy , Kim Sang-Bae , Lee Ju-Seog , O'Brien Shaun , Hicks Philip D. , Basu Devraj , Singhal Sunil , Malavasi Fabio , Rustgi Anil K.
Published: April 2023

Supplementary Figures 1-8. Supplementary Fig. 1. CD11b+Gr1+ populations were isolated by FACS from spleens of tumor-bearing p120-/- and control mice. Supplementary Fig. 2. CD38 is expressed by the CD11b+Gr1+ population in a murine model of Barrett's Esophagus. Supplementary Fig. 3. The HNM007 tumors induce CD38 expression on MDSC population similarly to the autochthonous p120-/- tumors. Supplementary Fig. 4. Immunohistochemical analysis of HNM007 tumors co-injected with CD38High or CD38Low MDSCs. Supplementary Fig. 5. CD38high CD11b+Gr1+ cells produce higher levels of iNOS and pNFκB. Supplementary Fig.6. Network analysis of differentially regulated genes in CD38high and CD38low MDSCs shows upregulation of RB1 pathway. Supplementary Fig.7. Distribution of G-MDSC, M-MDSC and mature monocytes is perturbed in tumor-bearing Cd38-/- mice. Supplementary Fig. 8. CD38 is expressed on human MDSC-like cell population that is expanded in the peripheral blood of advanced-stage cancer patients.
Supplementary Figures 1 - 5 from Curcumin Promotes Autophagic Survival of a Subset of Colon Cancer Stem Cells, Which Are Ablated by DCLK1-siRNA
Authors: Kantara Carla , O'Connell Malaney , Sarkar Shubhashish , Moya Stephanie , Ullrich Robert , Singh Pomila
Published: April 2023

PDF file - 2102KB, Colon cancer cells positive for DCLK1, co-express CD44, while Lgr5+ve cells do not (S1). Localization of cells expressing DCLK1/Lgr5/CD44 within spheroidal growths (S2). Effect of curcumin on relative expression of indicated proteins in HCT-116 cells, growing as either 2D monolayers, or 3D spheroids or xenografts in athymic nude mice (S3). Curcumin induces autophagy in HCT-116 cells in culture (S4). Effect of curcumin�DCLK1-siRNA on levels of LC3-I/II and PCNA staining and on stem cell populations in HCT-116 xenografts (S5).
Supplementary Figure Legend and Reference from NKX3.1 Suppresses TMPRSS2–ERG Gene Rearrangement and Mediates Repair of Androgen Receptor–Induced DNA Damage
Authors: Bowen Cai , Zheng Tian , Gelmann Edward P.
Published: April 2023

Supplementary Figure Legend and Reference. Legend for Supplementary Figures S1-S7. Also includes Supplementary Reference.
Supplementary Methods and Figure Legends from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Authors: Faria Claudia C. , Golbourn Brian J. , Dubuc Adrian M. , Remke Marc , Diaz Roberto J. , Agnihotri Sameer , Luck Amanda , Sabha Nesrin , Olsen Samantha , Wu Xiaochong , Garzia Livia , Ramaswamy Vijay , Mack Stephen C. , Wang Xin , Leadley Michael , Reynaud Denis , Ermini Leonardo , Post Martin , Northcott Paul A. , Pfister Stefan M. , Croul Sidney E. , Kool Marcel , Korshunov Andrey , Smith Christian A. , Taylor Michael D. , Rutka James T.
Published: April 2023

Supplementary Methods and Figure Legends
Supplementary Figures 1 - 11 and Table 1 from Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like Cells
Authors: Ahmed Shafiq U. , Carruthers Ross , Gilmour Lesley , Yildirim Salih , Watts Colin , Chalmers Anthony J.
Published: April 2023

Supplementary Table 1. Analysis of clonogenics survival curves from Figure 1C and 1D. Supplementary Figure S1. Generation of orthotopic tumours from R10 and R15 GSCs. Supplementary Figure S2. GSCs are more resistant to IR induced cell death than paired bulk populations. Supplementary Figure S3. Cell cycle profile and proliferation rates of GSC and bulk population. Supplementary Figure S4. Enhanced activation of CHK1 in GSCs. Supplementary Figure S5. Absence of G1 cell cycle checkpoint in irradiated GBM cell lines. Supplementary Figure S6. Analysis of G2/M cell cycle checkpoint. Supplementary Figure S7. Rapid activation of G2/M cell cycle checkpoint in E2 CD133+ cells. Supplementary Figure S8. Treatment of G7 GSCs with the CHK1 inhibitor SCH 900776 (SCH). Supplementary Figure S9. Radiosensitisation of E2 and G7 cell lines with the CHK1 inhibitor CHIR 124 (CHIR). Supplementary Figure S10. Enhanced DNA repair attenuates radiosensitisation of E2 GSCs to CHK1 inhibitor (SCH). Supplementary Figure S11. Increase in gamma-H2AX foci in GSCs compared to bulk population following combined ATR and PARP inhibition.
Supplementary Figure S4 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Authors: Faria Claudia C. , Golbourn Brian J. , Dubuc Adrian M. , Remke Marc , Diaz Roberto J. , Agnihotri Sameer , Luck Amanda , Sabha Nesrin , Olsen Samantha , Wu Xiaochong , Garzia Livia , Ramaswamy Vijay , Mack Stephen C. , Wang Xin , Leadley Michael , Reynaud Denis , Ermini Leonardo , Post Martin , Northcott Paul A. , Pfister Stefan M. , Croul Sidney E. , Kool Marcel , Korshunov Andrey , Smith Christian A. , Taylor Michael D. , Rutka James T.
Published: April 2023

Supplementary Figure S4. Prognostic impact of p-cMET status in SHH medulloblastomas
Supplementary Figure S2 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Authors: Faria Claudia C. , Golbourn Brian J. , Dubuc Adrian M. , Remke Marc , Diaz Roberto J. , Agnihotri Sameer , Luck Amanda , Sabha Nesrin , Olsen Samantha , Wu Xiaochong , Garzia Livia , Ramaswamy Vijay , Mack Stephen C. , Wang Xin , Leadley Michael , Reynaud Denis , Ermini Leonardo , Post Martin , Northcott Paul A. , Pfister Stefan M. , Croul Sidney E. , Kool Marcel , Korshunov Andrey , Smith Christian A. , Taylor Michael D. , Rutka James T.
Published: April 2023

Supplementary Figure S2. Biological pathways and processes associated with high cMET and low cMET SHH medulloblastomas
Supplemental Figures from Effective Cancer Vaccine Platform Based on Attenuated Salmonella and a Type III Secretion System
Authors: Xu Xin , Hegazy Wael A.H. , Guo Linjie , Gao Xiuhua , Courtney Amy N. , Kurbanov Suhrab , Liu Daofeng , Tian Gengwen , Manuel Edwin R. , Diamond Don J. , Hensel Michael , Metelitsa Leonid S.
Published: April 2023

Supplemental Figures. S1: Chemokine/Cytokine Quantification in Serum and in Tumor Microenvironment. S2: Blocking of CXCR3 suppresses the infiltration of CD8 T cell. S3: Administration of 7DW8-5 results in activation of NKT cells, NK cells, and DC in mouse spleen.
Supplementary figures 1-7 from Full-Length Semaphorin-3C Is an Inhibitor of Tumor Lymphangiogenesis and Metastasis
Authors: Mumblat Yelena , Kessler Ofra , Ilan Neta , Neufeld Gera
Published: April 2023

Supplementary figures 1-7. Contains the 7 supplementary figures (1S to 7S) in PDF format. Fig. 1S: Characterization of the expression of class-3 semaphorin receptors in LEC Fig. 2S: Semaphorins that fail to contract LEC nevertheless induce contraction of other cell types. Fig. 3S: Measurement of cell contraction using the xCELLigence dual plate (RTCA) machine and FR-sema3C induced changes in in thentent of M2 macrophages in the tumors. Fig. 4S: Inhibition of BrdU incorporation in lEC by FR-sema3C. Fig. 5S: The effect of FR-sema3C on the Distribution of intrtumoral and peritumoral lymphatics Fig. 6S: The effect of tumor size on the development of lymph node metastases. Fig. 7: P65-Sema3C promotes the survival of A549 lung cancer cells.
supplementary figure 4 from Microenvironmental Remodeling as a Parameter and Prognostic Factor of Heterogeneous Leukemogenesis in Acute Myelogenous Leukemia
Authors: Kim Jin-A , Shim Jae-Seung , Lee Ga-Young , Yim Hyeon Woo , Kim Tae-Min , Kim Myungshin , Leem Sun-Hee , Lee Jong-Wook , Min Chang-Ki , Oh Il-Hoan
Published: April 2023

supplementary figure 4: the in-vivo engraftment of primary leukemia cells after co-culture on normal or AML-derived MSCs.
supplementary figure 1 from Microenvironmental Remodeling as a Parameter and Prognostic Factor of Heterogeneous Leukemogenesis in Acute Myelogenous Leukemia
Authors: Kim Jin-A , Shim Jae-Seung , Lee Ga-Young , Yim Hyeon Woo , Kim Tae-Min , Kim Myungshin , Leem Sun-Hee , Lee Jong-Wook , Min Chang-Ki , Oh Il-Hoan
Published: April 2023

supplementary figure 1: alterations of mesenchymal cell colonization and proliferation in the bone marrow samples of acute myeloid leukemia (AML) patients.
Supplementary Figure 5 from STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma
Authors: Lau Jasmine , Ilkhanizadeh Shirin , Wang Susan , Miroshnikova Yekaterina A. , Salvatierra Nicolas A. , Wong Robyn A. , Schmidt Christin , Weaver Valerie M. , Weiss William A. , Persson Anders I.
Published: April 2023

Figure S5: JAK1/2 inhibitors block a transient STAT3 activation following IR in cultured murine proneural HGG cells.
Supplementary Tables S1-S7 from Cytosolic TMEM88 Promotes Invasion and Metastasis in Lung Cancer Cells by Binding DVLS
Authors: Zhang Xiupeng , Yu Xinmiao , Jiang Guiyang , Miao Yuan , Wang Liang , Zhang Yong , Liu Yang , Fan Chuifeng , Lin Xuyong , Dong Qianze , Han Qiang , Zhao Huanyu , Han Yong , Han Xu , Rong Xuezhu , Ding Shuting , Wang Endi , Wang Enhua
Published: April 2023

Supplementary Tables S1-S7: Supplementary TableS1: Clinicopathological features of 40 paired fresh non-small cell lung cancer (NSCLC) samples Supplementary TableS2: Target sequences for siRNA and shRNA Supplementary TableS3: Primers for real-time RT-PCR Supplementary TableS4: Correlation of TMEM88 overexpression and clinicopathological features in 214 cases of non-small cell lung cancer (NSCLC) Supplementary TableS5: Summary of Cox univariate and multivariate regression analysis of the association between clinicopathological features and overall survival in 61 cases of non-small cell lung cancer (NSCLC) Supplementary TableS6: Expression of TMEM88 in various epithelial malignancies Supplementary TableS7: Correlation of cytosolic TMEM88 with the expression of p-P38 and Snail in 50 NSCLC specimens
Supplementary Figure 4 from STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma
Authors: Lau Jasmine , Ilkhanizadeh Shirin , Wang Susan , Miroshnikova Yekaterina A. , Salvatierra Nicolas A. , Wong Robyn A. , Schmidt Christin , Weaver Valerie M. , Weiss William A. , Persson Anders I.
Published: April 2023

Figure S4: Murine and human proneural HGG cells exposed to IR in vitro display reduced cell stiffness, reduced proliferation and increased TMZ resistance.
Supplementary Materials and Methods from Cytosolic TMEM88 Promotes Invasion and Metastasis in Lung Cancer Cells by Binding DVLS
Authors: Zhang Xiupeng , Yu Xinmiao , Jiang Guiyang , Miao Yuan , Wang Liang , Zhang Yong , Liu Yang , Fan Chuifeng , Lin Xuyong , Dong Qianze , Han Qiang , Zhao Huanyu , Han Yong , Han Xu , Rong Xuezhu , Ding Shuting , Wang Endi , Wang Enhua
Published: April 2023

Supplementary Materials and Methods
Supplementary Figures S1-S9 from Cytosolic TMEM88 Promotes Invasion and Metastasis in Lung Cancer Cells by Binding DVLS
Authors: Zhang Xiupeng , Yu Xinmiao , Jiang Guiyang , Miao Yuan , Wang Liang , Zhang Yong , Liu Yang , Fan Chuifeng , Lin Xuyong , Dong Qianze , Han Qiang , Zhao Huanyu , Han Yong , Han Xu , Rong Xuezhu , Ding Shuting , Wang Endi , Wang Enhua
Published: April 2023

Supplementary Figures S1-S9: Supplementary FigureS1: Expression and localization of TMEM88 in epithelial malignancies and non-small cell lung cancer (NSCLC) cell lines Supplementary FigureS2: Effect of TMEM88 on canonical Wnt signaling and expression of its downstream target genes Supplementary FigureS3: Co-localization of and interaction between TMEM88 and DVLS in different cellular compartments Supplementary FigureS4: Effects of TMEM88 on proliferation, migration, and invasion of NSCLC cells with cytosolic TMEM88 Supplementary FigureS5: Effects of TMEM88 on proliferation and invasion of non-small cell lung cancer cells Supplementary FigureS6: Effects of cytosolic TMEM88 on expression of epithelial-mesenchymal transition (EMT) proteins Supplementary FigureS7: Effect of TMEM88 and DVLS co-transfection on expression of Snail and invasion in NSCLC cells Supplementary FigureS8: Effects of co-transfecting TMEM88 and DVLS on proteins involved in Snail stabilization Supplementary FigureS9: Overexpression of TMEM88 did not influence expression of Snail, occludin, or ZO-1 in cells with membrane-bound TMEM88
Supplementary Figure 3 from STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma
Authors: Lau Jasmine , Ilkhanizadeh Shirin , Wang Susan , Miroshnikova Yekaterina A. , Salvatierra Nicolas A. , Wong Robyn A. , Schmidt Christin , Weaver Valerie M. , Weiss William A. , Persson Anders I.
Published: April 2023

Figure S3: IR induces a sustained cell-intrinsic mesenchymal transition in HGG cell cultures.
Supplementary Figure S1 from Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors
Authors: Gallagher Ferdia A. , Sladen Helen , Kettunen Mikko I. , Serrao Eva M. , Rodrigues Tiago B. , Wright Alan , Gill Andrew B. , McGuire Sarah , Booth Thomas C. , Boren Joan , McIntyre Alan , Miller Jodi L. , Lee Shen-Han , Honess Davina , Day Sam E. , Hu De-En , Howat William J. , Harris Adrian L. , Brindle Kevin M.
Published: April 2023

Supplementary Figure S1. Representative 31P-MRS spectra of EV5 and CA9/1 tumors.
Supplementary Methods from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Authors: Mudduluru Giridhar , Abba Mohammed , Batliner Jasmin , Patil Nitin , Scharp Maike , Lunavat Taral R. , Leupold Jörg Hendrik , Oleksiuk Olga , Juraeva Dilafruz , Thiele Wilko , Rothley Melanie , Benner Axel , Ben-Neriah Yinon , Sleeman Jonathan , Allgayer Heike
Published: April 2023

Supplementary Methods. Description of additional methods and procedures used in the study.
Supplementary Figure S7 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Authors: Mudduluru Giridhar , Abba Mohammed , Batliner Jasmin , Patil Nitin , Scharp Maike , Lunavat Taral R. , Leupold Jörg Hendrik , Oleksiuk Olga , Juraeva Dilafruz , Thiele Wilko , Rothley Melanie , Benner Axel , Ben-Neriah Yinon , Sleeman Jonathan , Allgayer Heike
Published: April 2023

Supplementary Figure S7. TCGA colorectal cancer database analysis on selected targets.
Supplementary Figure Legend from Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors
Authors: Gallagher Ferdia A. , Sladen Helen , Kettunen Mikko I. , Serrao Eva M. , Rodrigues Tiago B. , Wright Alan , Gill Andrew B. , McGuire Sarah , Booth Thomas C. , Boren Joan , McIntyre Alan , Miller Jodi L. , Lee Shen-Han , Honess Davina , Day Sam E. , Hu De-En , Howat William J. , Harris Adrian L. , Brindle Kevin M.
Published: April 2023

Supplementary Figure Legend. Legend for Supplementary Figure S1.
Supplemental Tables and Figures. from Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in Lung
Authors: Leng Shuguang , Wu Guodong , Collins Leonard B. , Thomas Cynthia L. , Tellez Carmen S. , Jauregui Andrew R. , Picchi Maria A. , Zhang Xiequn , Juri Daniel E. , Desai Dhimant , Amin Shantu G. , Crowell Richard E. , Stidley Christine A. , Liu Yushi , Swenberg James A. , Lin Yong , Wathelet Marc G. , Gilliland Frank D. , Belinsky Steven A.
Published: April 2023

Supplementary Table 1. Characteristics of study subjects in LSC and VSC Supplementary Table 2. Common SNPs associated with risk for MGMT methylation in LSC GWAS discovery with p<10-5 in models with or without adjustment for rs16906252 Supplementary Table 3. Covariates included for adjustment in GLM. Supplementary Table 4. Delta changes for AUC ROC in logistic regressions with MGMT methylation as the outcome.Supplementary Table 5. The joint effect of the cis- (rs16906252) and trans- (rs16957091) acting SNPs on the risk for MGMT methylation in LSC and VSC Supplementary Figure 1. Quantile-quantile plots for GWAS discovery results in LSC. Supplementary Figure 2. Manhattan plot for genome-wide association in the LSC discovery set. Supplementary Figure 3. The enrichment of SNPs in ENCODE-annotated regulatory regions within the 472-kb haplotype block at chromosome 15q15.2 locus using data from small airway epithelial cells (SAEC).
Supplementary Table 2 from PML/RARα-Regulated miR-181a/b Cluster Targets the Tumor Suppressor RASSF1A in Acute Promyelocytic Leukemia
Authors: Bräuer-Hartmann Daniela , Hartmann Jens-Uwe , Wurm Alexander Arthur , Gerloff Dennis , Katzerke Christiane , Verga Falzacappa Maria Vittoria , Pelicci Pier Giuseppe , Müller-Tidow Carsten , Tenen Daniel G. , Niederwieser Dietger , Behre Gerhard
Published: April 2023

Genetic and morphological characteristics of AML patients and healthy donors used for miR-181a/b expression and RASSF1A protein analysis.
Supplementary Figures 1-5 from Targeting Pancreatic Cancer Metastasis by Inhibition of Vav1, a Driver of Tumor Cell Invasion
Authors: Razidlo Gina L. , Magnine Christopher , Sletten Arthur C. , Hurley Rachel M. , Almada Luciana L. , Fernandez-Zapico Martin E. , Ji Baoan , McNiven Mark A.
Published: April 2023

Supplementary Figures 1-5. Supplementary Figure 1. Vav1 is expressed in a subset of tumor cell lines. Supplementary Figure 2. Azathioprine does not inhibit migration by pancreatic tumor cells. Supplementary Figure 3. Vav1 is expressed in tumors from a genetic model of pancreatic cancer. Supplementary Figure 4. Azathioprine treatment does not impact tumor size in mouse models of pancreatic cancer. Supplementary Figure 5. Azathioprine reduces cell propagation in a Vav1-independent manner.
Supplementary Figure 2 from PML/RARα-Regulated miR-181a/b Cluster Targets the Tumor Suppressor RASSF1A in Acute Promyelocytic Leukemia
Authors: Bräuer-Hartmann Daniela , Hartmann Jens-Uwe , Wurm Alexander Arthur , Gerloff Dennis , Katzerke Christiane , Verga Falzacappa Maria Vittoria , Pelicci Pier Giuseppe , Müller-Tidow Carsten , Tenen Daniel G. , Niederwieser Dietger , Behre Gerhard
Published: April 2023

Western blot analysis of p53 protein in puromycin and gfp sorted miR-ZIP-expressing NB4 cells. GAPDH was used as internal control. Values below the blots represent the median {plus minus} SD from three independent experiments.
Supplementary Figure 4 from Breast Cancer Detection by B7-H3–Targeted Ultrasound Molecular Imaging
Authors: Bachawal Sunitha V. , Jensen Kristin C. , Wilson Katheryne E. , Tian Lu , Lutz Amelie M. , Willmann Jürgen K.
Published: April 2023

Supplementary Figure 4. Evaluation of B7-H3 Expression on Vascular Endothelial Cells.
Supplemental Figures S1-S5 from SYK Is a Candidate Kinase Target for the Treatment of Advanced Prostate Cancer
Authors: Ghotra Veerander P.S. , He Shuning , van der Horst Geertje , Nijhoff Steffen , de Bont Hans , Lekkerkerker Annemarie , Janssen Richard , Jenster Guido , van Leenders Geert J.L.H. , Hoogland A. Marije M. , Verhoef Esther I. , Baranski Zuzanna , Xiong Jiangling , van de Water Bob , van der Pluijm Gabri , Snaar-Jagalska B. Ewa , Danen Erik H.J.
Published: April 2023

Supplemental Figures S1-S5 Figure S1. Whole organism automated bioimaging assay differentiates between androgen independent / metastatic and androgen-dependent / non-metastatic prostate cancer cells. Figure S2. SYK depletion attenuates PC3 dissemination in zebrafish xenografts. Figure S3. Reduced protein expression of SYK in PC3shSYK cells. Figure S4. SYK depletion attenuates PC3 3D ECM invasion. Figure S5. SYK depletion attenuates colony formation but does not affect AKT activity or CD44 protein expression.
Table Supplementary S-I from Chemotherapeutic Agents Subvert Tumor Immunity by Generating Agonists of Platelet-Activating Factor
Authors: Sahu Ravi P. , Ocana Jesus A. , Harrison Kathleen A. , Ferracini Matheus , Touloukian Christopher E. , Al-Hassani Mohammed , Sun Louis , Loesch Mathew , Murphy Robert C. , Althouse Sandra K. , Perkins Susan M. , Speicher Paul J. , Tyler Douglas S. , Konger Raymond L. , Travers Jeffrey B.
Published: April 2023

Table Supplementary S-I. Glycerophosphocholine species generated in response to etoposide treatment of B16F10 cells
Supplementary Video S1 from Real-time Imaging of the Resection Bed Using a Handheld Probe to Reduce Incidence of Microscopic Positive Margins in Cancer Surgery
Authors: Erickson-Bhatt Sarah J. , Nolan Ryan M. , Shemonski Nathan D. , Adie Steven G. , Putney Jeffrey , Darga Donald , McCormick Daniel T. , Cittadine Andrew J. , Zysk Adam M. , Marjanovic Marina , Chaney Eric J. , Monroy Guillermo L. , South Fredrick A. , Cradock Kimberly A. , Liu Z. George , Sundaram Magesh , Ray Partha S. , Boppart Stephen A.
Published: April 2023

Positive surgical margin. Video OCT cross-sectional images of a positive tumor margin from the in vivo resection bed of a 72 year-old female WLE patient with invasive ductal carcinoma as the surgeon sweeps the handheld probe along the margin.
Supplementary Tables S1-S3 for Dang et al from ΔNp63α Promotes Breast Cancer Cell Motility through the Selective Activation of Components of the Epithelial-to-Mesenchymal Transition Program
Authors: Dang Tuyen T. , Esparza Matthew A. , Maine Erin A. , Westcott Jill M. , Pearson Gray W.
Published: April 2023

Supplementary tables related to miRNA wounding screen.
Supplementary Figures, Legends, and Methods from ΔNp63α Promotes Breast Cancer Cell Motility through the Selective Activation of Components of the Epithelial-to-Mesenchymal Transition Program
Authors: Dang Tuyen T. , Esparza Matthew A. , Maine Erin A. , Westcott Jill M. , Pearson Gray W.
Published: April 2023

Contains Supplementary Figures S1-S7, Supplementary Figure Legends and Supplementary Methods.
Supplementary Methods from Intratumoral Heterogeneity in EGFR-Mutant NSCLC Results in Divergent Resistance Mechanisms in Response to EGFR Tyrosine Kinase Inhibition
Authors: Soucheray Margaret , Capelletti Marzia , Pulido Inés , Kuang Yanan , Paweletz Cloud P. , Becker Jeffrey H. , Kikuchi Eiki , Xu Chunxiao , Patel Tarun B. , Al-shahrour Fatima , Carretero Julián , Wong Kwok-Kin , Jänne Pasi A. , Shapiro Geoffrey I. , Shimamura Takeshi
Published: April 2023

Description of additional methods and procedures used in the study.
Supplementary Figures S1-S6 from Intratumoral Heterogeneity in EGFR-Mutant NSCLC Results in Divergent Resistance Mechanisms in Response to EGFR Tyrosine Kinase Inhibition
Authors: Soucheray Margaret , Capelletti Marzia , Pulido Inés , Kuang Yanan , Paweletz Cloud P. , Becker Jeffrey H. , Kikuchi Eiki , Xu Chunxiao , Patel Tarun B. , Al-shahrour Fatima , Carretero Julián , Wong Kwok-Kin , Jänne Pasi A. , Shapiro Geoffrey I. , Shimamura Takeshi
Published: April 2023

NSCLC harboring EGFR kinase domain mutation develops EGFR TKI resistance with mesenchymal phenotype (S1); Chronic exposure of HCC4006 cells to TGFβ1 promotes EMT and gefitinib resistance (S2); Chronic EGFR inhibition in EGFR mutant NSCLC cells promotes TGFβ1 secretion and SMAD pathway activation (S3); Concurrent EGFR and TGFβR inhibition prevents mesenchymal transition but does not avert emergence of EGFR TKI resistance (S4); AZD9291 treatment induces significant apoptosis in HCC4006GeSB-R cells with acquired T790M mutation (S5); Distribution of cells harboring T790M in PC9 and HCC4006 cells and STR analysis for HCC4006 cells and HCC4006 gefitinib resistant cells (S6).
Supplementary Table S5 from Activation Status of the Pregnane X Receptor Influences Vemurafenib Availability in Humanized Mouse Models
Authors: MacLeod A. Kenneth , McLaughlin Lesley A. , Henderson Colin J. , Wolf C. Roland
Published: April 2023

Pharmacokinetic parameters of vemurafenib in huPXR/huCAR/huCYP3A4/3A7 mice pre-treated with RIF or PB.
Supplementary Table S4. from Activation Status of the Pregnane X Receptor Influences Vemurafenib Availability in Humanized Mouse Models
Authors: MacLeod A. Kenneth , McLaughlin Lesley A. , Henderson Colin J. , Wolf C. Roland
Published: April 2023

PK parameters of vemurafenib in huPXR/huCAR/huCYP3A4/3A7 and huPXR/huCAR mice pre-treated with RIF.
Supplementary tables 1-4 and figures 1-4 from NHANES 2009–2012 Findings: Association of Sexual Behaviors with Higher Prevalence of Oral Oncogenic Human Papillomavirus Infections in U.S. Men
Authors: Chaturvedi Anil K. , Graubard Barry I. , Broutian Tatevik , Pickard Robert K.L. , Tong Zhen-yue , Xiao Weihong , Kahle Lisa , Gillison Maura L.
Published: April 2023

Supplementary tables 1-4 and figures 1-4: Table 1: Comparison of non-participants/non-responders versus participants/responders for the oral HPV protocol of NHANES 2009-2012. Table 2: Comparison of oral HPV prevalence between NHANES 2009-2010 and NHANES 2011-2012. Table 3: Prevalence of oral oncogenic HPV infection and unadjusted prevalence differences by demographic and behavioral characteristics among men and women in the U.S., NHANES 2009-2012. Table 4: Adjusted associations of demographic and behavioral factors with HPV prevalence for 12 oncogenic HPV types among men and women in the U.S. population, NHANES 2009-2012. Figure 1: Adjusted association of age with oral oncogenic HPV prevalence among men and women in the U.S., NHANES 2009-2012. Figure 2: Prevalence of oral oncogenic HPV among men and women in the U.S. (NHANES 2009-2012) using a revised classification for oncogenic types. Figure 3: Burden of 12 oral oncogenic HPV infection among men in the U.S. population, NHANES 2009-2012. Figure 4: Burden of 12 oral oncogenic HPV infection among women in the U.S. population, NHANES 2009-2012.
Supplementary Figures S1-6 from ErbB3–ErbB2 Complexes as a Therapeutic Target in a Subset of Wild-type BRAF/NRAS Cutaneous Melanomas
Authors: Capparelli Claudia , Rosenbaum Sheera , Berman-Booty Lisa D. , Salhi Amel , Gaborit Nadège , Zhan Tingting , Chervoneva Inna , Roszik Jason , Woodman Scott E. , Davies Michael A. , Setiady Yulius Y. , Osman Iman , Yarden Yosef , Aplin Andrew E.
Published: April 2023

Supplementary Figures S1-6 Supplemental Fig. S1. ErbB3 and ErbB4 expression in melanoma cell lines. Supplemental Fig. S2. Depletion of NRG1 inhibits ErbB3 downstream signaling and cell growth in WT/WT melanoma cell lines. Supplemental Fig. S3. Depletion of ErbB3 reduces AKT and ERK1/2 phosphorylation. Supplemental Fig. S4. huHER3-8 reduces AKT phosphorylation. Supplemental Fig. S5. Pertuzumab reduces phosphorylation of AKT and ERK1/2 and inhibits cell growth. Supplemental Fig. S6. MEK inhibitors increase pertuzumab efficacy in xenografts.
Supplemental Methods and Figure Legends from ErbB3–ErbB2 Complexes as a Therapeutic Target in a Subset of Wild-type BRAF/NRAS Cutaneous Melanomas
Authors: Capparelli Claudia , Rosenbaum Sheera , Berman-Booty Lisa D. , Salhi Amel , Gaborit Nadège , Zhan Tingting , Chervoneva Inna , Roszik Jason , Woodman Scott E. , Davies Michael A. , Setiady Yulius Y. , Osman Iman , Yarden Yosef , Aplin Andrew E.
Published: April 2023

Supplemental Methods and Figure Legends