bluuebunny/crossref_metadata_2025 huggingface dataset:
Dimensión simbólica de la competencia intercultural en clase de lenguas extranjeras
Authors: Carrillo López Carolina
Published: September 2022

La clase de lenguas extranjeras se muestra como un espacio social, que va a permitir el encuentro de la cultura propia de los estudiantes como la de la(s) cultura(s) de la(s) lengua que se está(n) aprendiendo. Este encuentro, a través de la competencia intercultural, puede desarrollarse mediante diferentes dimensiones, y una de ellas va a corresponder a la simbólica, así los elementos que la conforman, entre ellos: los artefactos culturales, prácticas culturales, tradiciones y significaciones. De ahí que el docente no deba enfocarse únicamente en cuestiones de la lengua y cultura de acogida, sino también, poner al descubierto cómo éstas van a interrelacionarse con la lengua y cultura de salida. Por consiguiente, los alumnos irán desarrollando mayor apertura, curiosidad e interés por saber quién es el otro, al mismo tiempo que se (re)conocen a sí mismos, en un diálogo intercultural, lo que da, entonces, sentido al propio simbolismo cultural y al del otro.
Predictive Maintenance of Aircrafts on Large Scale Industrial Units Using Machine Learning Algorithms
Authors: Ganie Abdul Basit , Singh Er. Jasdeep
Published: September 2022

Abstract: Anticipating aircraft breakdowns is one of Industry 4.0's primary goals. It's critical to be able to prevent failures since downtime costs money and results in a loss of productivity. That's why it's critical for aircraft maintenance to figure out how many cycles or RULs are left till the breakdown occurs. The RUL estimates should be based on earlier observations wherever feasible under the same conditions. The research of RUL estimation is primarily centered on the creation of systems that monitor the current condition of equipment. While this topic is extensively researched, there is no single universal approach. This concept, which employs recurrent neural networks (RNN) for the predictive maintenance of the planned system, is motivated by the lack of a generic technique
Provably accurate simulation of gauge theories and bosonic systems
Authors: Tong Yu , Albert Victor V. , McClean Jarrod R. , Preskill John , Su Yuan
Published: September 2022

Quantum many-body systems involving bosonic modes or gauge fields have infinite-dimensional local Hilbert spaces which must be truncated to perform simulations of real-time dynamics on classical or quantum computers. To analyze the truncation error, we develop methods for bounding the rate of growth of local quantum numbers such as the occupation number of a mode at a lattice site, or the electric field at a lattice link. Our approach applies to various models of bosons interacting with spins or fermions, and also to both abelian and non-abelian gauge theories. We show that if states in these models are truncated by imposing an upper limit Λ on each local quantum number, and if the initial state has low local quantum numbers, then an error at most ϵ can be achieved by choosing Λ to scale polylogarithmically with ϵ−1, an exponential improvement over previous bounds based on energy conservation. For the Hubbard-Holstein model, we numerically compute a bound on Λ that achieves accuracy ϵ, obtaining significantly improved estimates in various parameter regimes. We also establish a criterion for truncating the Hamiltonian with a provable guarantee on the accuracy of time evolution. Building on that result, we formulate quantum algorithms for dynamical simulation of lattice gauge theories and of models with bosonic modes; the gate complexity depends almost linearly on spacetime volume in the former case, and almost quadratically on time in the latter case. We establish a lower bound showing that there are systems involving bosons for which this quadratic scaling with time cannot be improved. By applying our result on the truncation error in time evolution, we also prove that spectrally isolated energy eigenstates can be approximated with accuracy ϵ by truncating local quantum numbers at Λ=polylog(ϵ−1).
Critical Review on Sushruta’s Management of Bhagna
Authors: Jaivarshaa GV Dr. Pavithra , Dasar Dr. Devyani , Biswas Dr. Shubham , Singh Dr. Naveen , Mavale Dr. Abhishek
Published: September 2022

Right from ancient years to contemporary times, trauma care has been an important goal of emergency management. Orthopedic injuries have a high incidence and remain a significant challenge for trauma care. Sushruta Samhita has an extensive description of the management of orthopedic injuries like fractures and dislocations. According to Ayurvedic scriptures, a fracture is the loss of the bone's continuity due to pressure. The fundamental principles of fracture therapy, such as Reduction, Immobilization, and Rehabilitation, are used to treat long bone fractures. Many indigenous substances that can aid in fracture healing are documented in ancient treatises. This study aimed to explore the types and management protocol of fracture Acharya Sushruta. The method was followed to analyze Sushruta Samhita, its commentaries, and Internet surfing from various research articles. In Sushruta Samhita, the maximum information about the disease fracture, its classification, and symptoms are elaborated in the fifteenth chapter of nidan sthan and its management was described in the third chapter of chikitsa sthan along with extensive details of surgical and non-surgical management, dietetic indications and local applications. Ancient surgeons prioritized fractures of the pelvic area, spines, long bone shafts, and thighs, among various fractures. The rules established by Acharya Sushruta are so authentic that even today's orthopedic surgeons follow them. Traction and retention were used after Unnamana (elevation of the depressed fragment) and Vinamana (depression of elevated fragment) while managing shattered bones. Sudha varga dravyas were used in compound fractures, multiple fractures, and irregular fractures when the broken section is completely separated or missed in certain circumstances. As a graft material, a paste made from the decoction of Rubia cordifolia, Sudhavarga dravya, and latex of Ficus Benghalensis was applied. The research provided a thorough literature review on fracture and fundamental principles, which are valid even in today's orthopedics.
Quercetin Nanoparticles- A Promising Approach to Cancer Treatment: A Review
Authors: Deb Barsha , Thakur Nishant
Published: September 2022

Quercetin, a naturally occurring polyphenolic element, has rapidly received attention as an anticancer agent. Although quercetin has demonstrated potent medical value, its application as an antitumor drug is limited because of poor solubility, low absorption, and fat metabolism. Nanoparticles are effective and versatile drug delivery devices because they can improve the solubility, pharmacokinetics, bio distribution, and in vivo stability of the free drug. The utilization of Nano-carrier scanning increases the bioavailability of the drug. Quercetin nanoparticles have shown high encapsulation efficiency, stability, sustained release, extended circulation time, improved accumulation at tumor sites, and therapeutic efficacy. This review article aims to estimate the anticancer efficiency of polymeric nanoparticles of quercetin. The majority of research is based on the preclinical anticancer activities of quercetin nanoparticles. MCF cells of breast cancer (BC), A 549 cells of lung cancer, cells of HepG2 liver malignancy, and cells of malignance are the primary targets for possible anticancer activity. Furthermore, combining quercetin with other diagnostic or therapeutic agents in a single Nano carrier has resulted in improvements in tumor detection or treatment. The antitumor outcome of drugs that are used in cancer therapy can also be supported by quercetin nanoparticles by increasing the anti-tumor development or decreasing the systemic toxicity level of the drug. Keywords: , , ,
Apontamentos interpretativos e jornalísticos sobre a Amazônia: o discurso de Bolsonaro na ONU
Authors: Silva Ventura Jússia Carvalho , Costa Alda , Ventura Neto Raul , Oliveira Ivana
Published: September 2022

Neste artigo, indagam-se quais sentidos são produzidos pelas narrativas jornalísticas sobre a Amazônia a partir do discurso do presidente Bolsonaro na ONU, em 2020, quando culpa indígenas e caboclos pelas queimadas. Problematizamos e demarcamos o silenciamento de vozes como uma categoria de violência do poder nas falas institucionais e narrativas jornalísticas diante dos fatos sociais. Analisamos 11 matérias veiculadas em jornais locais de seis dentre os nove Estados da Amazônia Legal. A partir de uma visada teórico-metodológica da Hermenêutica em Profundidade (THOMPSON, 2011), tendo como técnica a análise narrativa, constatamos que, ainda é acionado um número restrito de ideias, centrando os fatos nos enquadramentos primários oficialistas, com ausência de vozes plurais na compreensão do universo político, econômico, cultural e social da Amazônia.
Memória e temporalidade em narrativas jornalísticas: a efeméride “BH 120 anos” no jornal Estado de Minas
Authors: Cavalcanti Anna , Amormino Luciana
Published: September 2022

Levando em consideração que o jornalismo pode ser um dos agentes para a constituição da memória social, este artigo reflete sobre a efeméride de aniversário de cidades em especiais jornalísticos. Partindo desse tema, discute o caráter de agenciamento da memória da cidade por parte do jornalismo e a tentativa de o jornalismo estreitar seu pertencimento e vínculo à memória da cidade. Para isso, é analisado o especial multimídia “BH 120 anos”, lançado pelo jornal Estado de Minas em 2017, por ocasião do aniversário de Belo Horizonte. Por meio de uma análise hermenêutica, busca-se refletir sobre as temporalidades, o gesto de memória efetuado e as estratégias narrativas adotadas que permitem vislumbrar um duplo movimento em relação à memória da cidade feito pela narrativa jornalística.
O limiar da piscina: uma análise do filme "Que horas ela volta?" em diálogo com o imaginário sobre a desigualdade social brasileira
Authors: Negri Anaurelino , Tietzmann Roberto
Published: September 2022

Neste trabalho realizamos uma análise do filme Que horas ela volta? (MUYLAERT, 2015) com ênfase na figura da piscina e em sua simbologia na narrativa da obra, por meio do referencial teórico de autores vinculados ao estudo da imagem e da arte. Tomamos como ponto de partida a compreensão do cinema como um registro documental de seu tempo, que nos permite refletir sobre o mundo que retrata em uma perspectiva histórica. A partir desse paradigma inicial conduzido pela teoria de Kracauer (1960) e por reflexões pregressas de Schopenhauer (2014), traçamos paralelos entre a figura da piscina presente no filme e o conceito de imagem dialética — derivado da leitura de Didi-Huberman (1998) — diante da trama de relações entre as personagens e o seu contexto político e social no imaginário brasileiro.
Can the method of CBCT interpretation influence endodontic diagnosis?
Authors: Mendonça dos Santos Alessandra , Montagner Francisco , Viana Wanzeler Ana Márcia , Dias da Silveira Heraldo Luis , Assein Arús Nádia , Boessio Vizzotto Mariana
Published: September 2022

Aim: This study evaluated the influence of the method used for visualization and analysis of cone-beam computed tomography (CBCT) on the diagnosis of endodontic conditions. Materials and methods: Twenty clinical cases containing twelve different endodontic conditions were analyzed by two specialists in dental radiology and one specialist in endodontics. Initially, the evaluators viewed the cases in Portable Document Format (PDF) containing a selection of digital images and, by consensus, described their diagnostic hypotheses for each case. One week later, the evaluators reassessed the cases, this time using multiplanar reconstructions with a Digital Imaging and Communications in Medicine (DICOM) format image viewer. Once more, by consensus, they recorded their diagnostic hypotheses. Results: In 10% of the cases there was a discrepancy between the diagnoses made using preselected digital images in PDFs and by viewing multiplanar reconstructions. The visualization of the PDF images obtained a sensitivity of 0.714, specificity of 0.966, and 90% accuracy. Discussion: In the majority of these cases, endodontic conditions identified using the DICOM image viewer (multiplanar reconstruction) were not detected using the PDFs of preselected images. Conclusion: Although more studies are needed, the authors reiterate that using multiplanar reconstructions should always be preferred to other forms of analysis for CBCT, so that the maximum diagnostic potential of the imaging exam can be achieved.
Terapia de fotobiomodulação no tratamento de lesões no nervo alveolar inferior
Authors: Freitas Helly Wesley França , Cavalcanti Pedro Henrique Lopes , Figueiredo Viviane Maria Gonçalves de , Barreto Kamila Azoubel
Published: September 2022

Objetivo: Realizar uma revisão integrativa da literatura acerca da eficácia da terapia de fotobiomodulação na amenização dos distúrbios neurossensoriais e da dor em pacientes com lesões no nervo alveolar inferior. Materiais e métodos: Para a pesquisa dos artigos foram utilizadas as bases de dados MEDLINE, LILACS, BBO, IBECS e SciELO com descritores em inglês combinados com os operadores booleanos. A busca limitou-se a artigos nos idiomas inglês, português ou espanhol, publicados nos últimos 10 anos, do tipo ensaios clínicos. Revisão de literatura: Nove artigos preencheram os critérios de inclusão, sendo oito ensaios clínicos randomizados e um ensaio clínico não randomizado. Os melhores resultados foram observados em testes de sensibilidade geral utilizando a Escala Visual Analógica. Os estudos atestaram melhora da condição independentemente do tempo pós-operatório, contudo, o início antecipado da terapia trouxe maiores benefícios. Ademais, embora a maioria dos artigos tenha apontado eficácia do tratamento, notou-se grande variabilidade nos protocolos de terapia a laser. Conclusão: O emprego da terapia de fotobiomodulação é eficaz no tratamento de injúrias iatrogênicas no nervo alveolar inferior. Entretanto, mais estudos são necessários a fim de estabelecer um protocolo para o uso do laser.
Métodos de ensino: uma experiência visando a observar alterações no processo de aprendizagem
Authors: Louro Filho Paulo Pereira , Barros Eduardo Roberto Corrêa de
Published: September 2022

Os autores estudaram, comparativamente, os métodos de ensino empregados pela Cátedra de Microbiologia da Faculdade de Odontologia da U. F . R. G. S ., junto aos alunos da primeira série, durante os anos de 1965 e 1966, em uma mesma unidade de estudo. Tiveram, assim, oportunidade de analisar, em função de métodos diferentes de ensino, o processo de aprendizagem dos mesmos alunos, considerando como aproveitamento da matéria estudada, os graus obtidos na avaliação correspondente.
Planejamento de um programa piloto em bases incrementais
Authors: Fossati G.
Published: September 2022

Discute-se a importância do planejamento na elaboração de um programa incremental. Determina-se as necessidades de tratamento, tomando por base dados de um levantamento em um grupo de crianças da cidade de Pôrto Alegre. Comparam-se os recursos disponíveis na comunidade com as necessidades de tratamento. São apresentadas e analisadas algumas hipóteses de solução do problema cárie dentária. É selecionado um específico programa de ação, em função do objetivo e da política do serviço.
Mucosa vestibular da mandíbula insensibilizada pela anestesia regional do nervo dentário inferior: comprovação clínica para fins de exodontia
Authors: Aydos Jorge Hugo
Published: September 2022

No presente trabalho procura-se verificar, clínicamente, os efeitos da anestesia do nervo dentário inferior sobre a gengiva vestibular da mandíbula, compreendida entre o buraco mentoniano e a linha média do lado correspondente, e também sobre a mesma área do lado oposto ao da anestesia, com o objetivo de eliminar a anestesia terminal vestibular em casos de exodontia nesta região.
Desinfecção pela água em ebulição: determinação do tempo necessário
Authors: Silva Sergio Carvalho e
Published: September 2022

Pesquisa sôbre a desinfecção através da água em ebulição. Determinação do tempo necessário.
Sílica e suas variedades alotrópicas: contribuição ao estudo de seu uso em odontologia
Authors: Oliveira Euclides Luiz De
Published: September 2022

Investigação bibliográifica sôbre a sílica e suas transformações alotrópicas. Foi observado que poucos trabalhos que detalham o assunto em profundidade foram publicados. Observou-se que a infraestrutura da sílica é o ponto onde se devem buscar as explicações para os fenômenos da expansão térmica e outras manifestações físicas e químicas. Tais fenômenos são decorrência de modificações da estrutura atômica da sílica.
Placa bacteriana
Authors: Louro Filho Paulo Pereira , Santos Jose Oscar Schneider , Tovo L. C.
Published: September 2022

Os autores resolveram realizar uma revisão bibliográfica sôbre placa bacteriana, acreditando na suma importância da relação desta com o início do desenvolvimento de cárie dentária e doenças periodontais. O trabalho desenvolvido em nove etapas, das quais três são apresentadas nesta parte, é esperado se completado nos três próximos números da revista.
Ameloblastomas derivados de cistos dentígeros: apresentação de casos
Authors: Ebling Hardy , Chahér José
Published: September 2022

Estudou-se sob o ponto de vista clínico, radiológico e histopatológico quatro casos de ameloblastomas, dos quais três derivados de cisto dentígero. Chama-se a atenção para o trabalho do patologista que deve ser o de excluir a possibilidade de considerar como cistos dentígeros, lesões que apresentem transformação ameloblastomatosas.
Especificações brasileiras para materiais dentários
Authors: Süffert Léo Werner
Published: September 2022

Justificativa para a adoção de Especificações Brasileiras para Materiais Dentários e conceituação de especificações com critérios e regras para o estabelecimento das mesmas. Metodização para comparar resultados ou dados relacionados com propriedades físicas e mecânicas obtidas por diferentes laboratórios e/ou uma especificação. As especifica-fabricantes. Principais tópicos de ções Brasileiras (15) adotadas pelo grupo brasileiro de materiais dentários fundado em setembro de 1965 em Pôrto Alegre. Constituem-se em 9 especificações da Federação Dentária Americana.

Quando, perantw o Grupo Brasileiro de Materiais Dentários, reunido por primeira vez, na cidade de Pôrto Alegre, em setembro de 1965, propuzemos que êste adotasse as Especificações da Fédération Dentaire International, bem como algumas Especificações da American Dental Association, como Especificações Brasileiras para Materiais Dentários, tecemos algumas considerações sôbre o assunto, procurado justificar o porquê de nossa produção.

Ao analisarmos o assunto Especificações, parece-nos oportuno perguntar:
Prótese e traumatologia maxilo-faciais: coletânea de exercícios de fixação
Authors: Soares Brandão Gaspar
Published: September 2022

O objetivo é facilitar aos discentes o desempenho de tarefas práticas com lndicações básicas e técnicas simples do que têm a realizar. Os numerosos aparelhos, dispositivos e próteses, elaborados segundo métodos que variam ao infinito, foram selecionados procurando cobrir a maior área de casos clínicos possíveis, ao mesmo tempo que somadas às experiências cumulativas, possam oferecer estrutura para o exercício profissional e suporte a cursos de pós-graduação. As variantes técnicas ditadas pela experiências e adestramento serão agregadas, sem alteração do lastro oferecido, completando a formação profissional.
Treinamento ou preparo de pessoal docente
Authors: Werner Stüffert Léo
Published: September 2022

Necessidade de uma formação específica de pessoal docente de ensino superior, visando melhor compreensão do processo ensino-aprendizagem. No Brasil, importante a ação da ABENO e CAPES, estabelecendo Centros de Treinamento onde o professor (instrutor ou assistente) dedica-se integralmente aos mais variados aspectos do ensino em seu setor. Tais Centros de Treinamento, escolhidos pela excelência do ensino ministrado, devem preocupar-se com a tecnologia educacional. Cursos relacionados com Tecnologia Educacional devem ser ministrados regularmente, objetivando um preparo sistemático e obrigatório do pessoal docente.
Halitose
Authors: Fortes Livio Borges
Published: September 2022

Nenhum resumo disponível
Ação diastásica da saliva em relação com o ph
Authors: Dos Santos Jayme Bandeira
Published: September 2022

Nenhum resumo disponível
Coloração de fibras de reticulina em material calcificado
Authors: Ebling Hardy
Published: September 2022

Nenhum resumo disponível
Odontoblasto (estudo comparativo)
Authors: Louro Leopoldo Marques
Published: September 2022

Nenhum resumo disponível
Cimento de silicato
Authors: Frajndlich Manoel
Published: September 2022

Nenhum resumo disponível
Evidenciação de microrganismos em tecidos dentários
Authors: Kilian Egon A.
Published: September 2022

Nenhum resumo disponível
Histoplasma Capsulatum
Authors: Santos José Oscar Schneider
Published: September 2022

Nenhum resumo disponível
Emprêgo das resinas acrílicas em prótese buco facial
Authors: Sant'Ana Manoel
Published: September 2022

Nenhum resumo disponível
Glossário de prótese buco-facial
Authors: Brandão G. Soares
Published: September 2022

Nenhum resumo disponível
Comparação entre duas técnicas de fixação rígida por meio de ensaio mecânico de compressão
Authors: Moraes Anna Cecília , Oliveira Marília Gerhardt de , Müller Paulo Roberto , Polido Waldemar D. , Gilapa Genaro Mamani
Published: September 2022

O presente trabalho visa avaliar in vitro, por meio de um ensaio mecânico de compressão, a resisténcia da fixação rígida através do uso de parafusos bicorticais auto-rosqueáveis, e o deslocamento dos fragmentos ósseos submetidos á aplicação de uma carga artificial, em dois grupos de osteotomias Sagitais do Ramo realizadas em mandíbulas de carneiro frescas. As osteotomias fixadas por trés parafusos no padrão de posicionamento horizontal, com angulação de 90° com a cortical vestibular foram estatisticamente mais resistentes do que as fixadas por dois parafusos no padrão de posicionamento horizontal, com angulação de 60° com a cortical vestibular.
Influência do acréscimo de porções pré-polimerizadas no grau de polimerização de compósitos odontológicos
Authors: Samuel Susana Werner , Silva Fabrício , Silva Karin Leite da
Published: September 2022

Tentando minimizar algumas limitações dos compósitos fotopolimerizáveis para dentes posteriores, Teruya et al’¹² preconizaram inserção de porçoes pré-polimerizadas nas restaurações. Para determinar se há interferência na passagem de luz através do compósito, foram realizados ensaios de dureza Knoop na superfície e fundo de vinte corpos de prova divididos em quatro grupos: |) controle; Il) com um monobloco de 1mm de espessura; III) com um monobloco de 2mm de espessura; IV) com um monobloco de 2,5mm de espessura. Os valores médios de dureza Knoop obtidos na superfície de fundo dos grupos foram respectivamente: |)78,27 e 74,23; Il) 75,01 e 74,53; Ill) 76,06 e 72,76; IV) 72,76 e 49,85. Os dados sumetidos a Análise de Variância e Teste de Tukey, permitiram concluir: A) O acréscimo de porções pré-polimerizadas de resina não alterou a dureza superficial dos corpos de prova; B) o acréscimo de porções pré-polimerizadas de até 2,0mm não interferiu na dureza superficial e fundo dos corpos de prova; C) o acréscimo de porções pré-plimerizadas com espessura superior ou igual a 2,5m reduziu, significativamente, a dureza de fundo dos corpos de prova.
The Relationship between Portuguese and Indigenous Languages in the Community of Portuguese Language Countries: An Existential Sociolinguistics Perspective
Authors: Balosa David
Published: September 2022

Abstract

 

This study analyzes the relationship between Portuguese and indigenous or regional and national languages in the Community of Portuguese Language Countries (CPLP). It proposes a multilingual language policy and the implementation of the political legitimacy of linguistic minority rights (PLLMR) as a demonstration of a decolonized treatment of languages other than Portuguese (LOTP) in the community. Using the theoretical framework of existential sociolinguistics and the method of philosophical reflection, this study addresses the question of how can CPLP implement multilingual policy in its governmental processes and sustain its Lusophone international politico-economic and sociocultural organization identity. In conclusion, it argues that the implementation of multilingual policy will demonstrate a decolonized governmental attitude, a sustainable existential intercultural mindset (SEIM), and a global intercultural citizenship in fostering existential justice rather than an anti-humanist governance or what I call econotechnocracy.
Derecho a la participación de las personas menores de edad en la actualidad
Authors: Ruiz-Jarquín Irene
Published: September 2022

Impulsar el derecho a la participación de las personas menores de edad en cada uno de sus contextos, que conduzca a la conformación de sociedades más democráticas e igualitarias es el objetivo principal de este texto. El ensayo repasa los acuerdos que se establecen en los instrumentos legales, nacionales e internacionales, y el trabajo que se realiza por medio de diferentes instancias costarricenses y la sociedad en general para garantizar el cumplimiento de este derecho. Como resultado, se evidencia la necesidad de concientizar sobre la importancia de fortalecer, conducir y propiciar espacios de participación donde estas personas se sientan seguras y empoderadas para dialogar sobre los diversos temas que afectan su diario vivir; en otras palabras, la edad no debe influir en los derechos de cada persona, por lo que sus opiniones deben de ser respetadas y analizadas para la toma de decisiones de cada sociedad. Por lo tanto, la participación infantil requiere plantearse condiciones más allá de la edad o la madurez de cada persona para participar, decidir u opinar, sino que debería implementarse su ejercicio desde temprana edad, con la observancia, en primer lugar, de cómo participan estos actualmente, ya sea en sus familias, en sus centros de estudio, en sus comunidades o con sus amigos, muchas veces con la tecnología como mediadora, para que se descubra mayores posibilidades y mejores maneras de promoverla.
DEVELOPMENT OF TEACHING MATERIALS FOR E-LEARNING-BASED STATISTICS MATERIALS ORIENTED TOWARDS THE MATHEMATICAL LITERACY ABILITY OF VOCATIONAL HIGH SCHOOL STUDENTS
Authors: Supianti In In , Yaniawati Poppy , Osman Siti Zuraidah Md , Al-Tamar Jasem , Lestari Niki
Published: September 2022

The aim of this study is the development of teaching materials for statistical materials based on Edmodo-assisted e-learning and how they impact students' mathematical literacy skills. The method used is the Dick & Carey development model. The research population is class XII Catering, one of the Vocational High Schools in Bandung City, with a sample of class XII Catering 1. The instrument used a mathematical literacy test, validation sheet, student response questionnaire, and interview guidelines. The data collected were analyzed descriptively qualitatively through triangulation, Q-Cochran statistical test, and N-Gain test. The results of this study indicate that the design of teaching materials for statistical materials based on Edmodo-assisted e-learning is very feasible to use in learning mathematics. Furthermore, the results of the application of teaching materials have a positive effect on mathematical literacy skills with a reasonably good category. Therefore, teaching materials must further develop animation, use communicative language, and utilize the latest technology
Pilot study on applying various research methodologies to investigate the effectiveness of e-learning materials
Authors: Szabó Bálint , Ollé János , László Szandra , Harmat Vanda , Vaszkun Balázs , Tóvölgyi Sarolta
Published: September 2022

The COVID-19 pandemic had a major impact on higher education. Students were required to adopt a more independent way of learning, and instructors had to redesign courses to fit the digital space. Increasingly frequent e-learning research provides substantial support for the expansion of online education. The aim of this article is to investigate the effectiveness of e-learning materials among university students using a variety of research methodologies (Groningen Sleep Quality Scale, psychomotor vigilance task, verbal fluency and digit span tests, NASA Task Load indeX and eye tracking). In a pilot study conducted in a laboratory environment, 15 participants were divided into three groups and assigned to study from prepared course pages using content-equivalent e-learning materials. The results demonstrated that the applied research methodologies were appropriate for investigating the issue, allowing the pilot study to reveal a set of criteria encompassing the preferences of students for course structures and e-learning materials.
Precision cut intestinal slices, a novel model of acute food allergic reactions
Authors: Hung Lisa , Celik Alper , Yin Xiaojun , Yu Kai , Berenjy Alireza , Kothari Akash , Obernolte Helena , Upton Julia , Bøgh Katrine Lindholm , Somers Gino R. , Siddiqui Iram , Grealish Martin , Quereshy Fayez A. , Sewald Katherina , Chiu Priscilla P.L. , Eiwegger Thomas
Published: September 2022

Background: Food allergy affects up to 8% of the pediatric
population. Despite ongoing efforts, treatment options remain limited.
Novel models of food allergy are needed to study response patterns
downstream of IgE-crosslinking and evaluate drugs modifying acute
events. Here, we report a novel human ex vivo model that displays
acute, allergen-specific, IgE-mediated smooth muscle contractions using
precision cut intestinal slices (PCIS). Methods: PCIS were
generated using gut tissue samples from children who underwent
clinically indicated surgery. Viability and metabolic activity were
assessed from 0-24h. Distribution of relevant cell subsets was confirmed
using single cell nuclear sequencing. PCIS were passively sensitized
using plasma from peanut allergic donors or peanut-sensitized
non-allergic donors, and exposed to various stimuli including serotonin,
histamine, FcɛRI-crosslinker and food allergens. Smooth muscle
contractions and mediator release functioned as readouts. A novel
program designed to measure contractions was developed to quantify
responses. The ability to demonstrate the impact of antihistamines and
immunomodulation from peanut oral immunotherapy (OIT) was assessed.
Results: PCIS viability was maintained for 24h. Cellular
distribution confirmed the presence of key cell subsets including mast
cells. The video analysis tool reliably quantified responses to
different stimulatory conditions. Smooth muscle contractions were
allergen-specific and reflected the clinical phenotype of the plasma
donor. Tryptase measurement confirmed IgE-dependent mast cell-derived
mediator release. Antihistamines suppressed histamine-induced
contraction and plasma from successful peanut OIT suppressed
peanut-specific PCIS contraction. Conclusion: PCIS represent a
novel human tissue-based model to study acute, IgE-mediated food allergy
and pharmaceutical impacts on allergic responses in the gut.
Urinary Zinc and Incident Type 2 Diabetes: Prospective Evidence From the Strong Heart Study
Authors: Galvez-Fernandez Marta , Powers Martha , Grau-Perez Maria , Domingo-Relloso Arce , Lolacono Nancy , Goessler Walter , Zhang Ying , Fretts Amanda , Umans Jason G. , Maruthur Nisa , Navas-Acien Ana
Published: September 2022

OBJECTIVE

Hyperglycemia can increase urinary zinc excretion. We evaluated the association of higher urinary zinc level with new diagnosis of incident type 2 diabetes mellitus (T2DM) in adult populations with a high burden of T2DM from AZ, OK, and ND and SD. We also assessed the cross-sectional association of urinary zinc levels with prevalent prediabetes.

RESEARCH DESIGN AND METHODS

We included 1,339 adults free of T2DM at baseline (1989–1991) followed through 1998–1999 in the Strong Heart Study (SHS) and 1,905 family members of SHS participants followed as part of the Strong Heart Family Study (SHFS) through 2006–2009.

RESULTS

T2DM incidence was 14.7% (mean follow-up 6.6 years) in the SHS and 13.5% (mean follow-up 5.6 years) in the SHFS. After adjustment for sex, site, education, smoking status, BMI, and estimated glomerular filtration rate, the hazard ratio of T2DM in comparing 75th vs. 25th percentiles of urinary zinc distribution was 1.21 (95% CI 1.08, 1.36) in the SHS and 1.12 (0.96, 1.31) in the SHFS. These associations were attenuated but significant in the SHS after adjustment for HOMA of insulin resistance (HOMA-IR) score. With exclusion of participants with prediabetes at baseline, urinary zinc remained significantly associated with T2DM in the SHS. In cross-sectional analyses, prediabetes was associated with higher urinary zinc levels.

CONCLUSIONS

Urinary zinc levels were associated with T2DM incidence and prediabetes prevalence even after adjustment for HOMA-IR in populations with a high burden of T2DM. These results highlight the importance of zinc metabolism in diabetes development.
The Concept of "Place" in Urban Studies
Authors: Dharma Tohjiwa Agus
Published: September 2022

In the domain of organizational ergonomics, the discussion of ergonomics focuses on sociotechnical systems that are strongly influenced by the environment. This paper is a review of the development of “place” theories in urban studies which can later be implemented in organizational ergonomics. Humans live in a city which is a collective urban artifact of a long historical process. Urban space will form a place which is an intrinsic part of the interaction between residents and the city area. Through a meaning, individuals or communities change space into a place. Thus, place is the center of meaning formed by life experiences. The place factor is undeniably the main support for the formation of urban identity. In urban studies, the concept of place can be seen in terms of "rootedness" and a sense of “consciousness” that arises from associations with the urban socio-physical environment. From there emerged the concept of place attachment which explains the symbolic relationship formed by a person who culturally provides an understanding of emotional attachment to his urban environment. Through understanding the concept of "place" it is hoped that we can achieve an ergonomic design that focuses more on human characteristics and uniqueness.
Regulatory Considerations for Co-Development Activities for a Therapeutic and an In Vitro or Companion Diagnostic within a Pharmaceutical or Biotech Company
Authors: AD Watson
Published: September 2022

The regulatory and research landscape for therapeutics is continually evolving globally. These changes are influenced by factors such as requirements by the regulatory agencies and health authorities, or strategic positioning of the product in the marketplace. Challenges also arise from the necessity to develop a therapeutic product in conjunction with an assay. The therapeutic company finds itself in unfamiliar territory and might not fully appreciate unforeseen challenges that could delay and even potentially derail a development program. Choosing the right partner to develop the assay and strategic choices regarding the source of regulatory expertise can be the difference between failure and success. This article provides considerations for regulatory professionals working within pharmaceutical or biotech companies that are actively pursuing In Vitro or companion diagnostics to accompany the products in their therapeutic portfolio.
Filing of DMF in US, Canada & Europe
Authors: Yamini Kanti S P
Published: September 2022

DMF (Drug Master File) it is a kind of confidential document which contains complete, factual and correct information about active pharmaceutical ingredient or finished drug dosage form. A DMF can be used by holder who establishes the file or by one or more parties in support of their files or applications. The Drug master file consist of 2 parts: (a) the applicant’s part – that contains all the information that the license holder needs to review about quality of drug product & (b) the restricted part – which contains all the confidential information about the manufacturing process that can only be presented in front of authorities. The purpose of this article is to present an overview of DMF filing in different countries which are USA, CANADA, and EUROPE. In USA, CANADA the drug master file is known as DMF only but in EUROPE it is known as ASMF (active substance master file).
Pharmaceuticals in Sudan: Developments in Regulation and Governance
Authors: Mustafa Omer Abdeen
Published: September 2022

The strategy of price liberalisation and privatisation had been implemented in Sudan over the last decade, and has had a positive result on government deficit. The investment law approved recently has good statements and rules on the above strategy in particular to pharmacy regulations. Under the pressure of the new privatisation policy, the government introduced radical changes in the pharmacy regulations. The 2001 Pharmacy and Poisons Act and its provisions established the Federal Pharmacy and Poison Board (FPPB). All the authorities of the implementation of Pharmacy and Poisons Act were given to this board. This article provides an overview of the impact of the pharmaceutical regulations on the quality of medicines on the Sudanese market from the perspective of the pharmacists working with drug importing companies. The information necessary to conduct the evaluation was collected from 30 pharmacists who are the owners or shareholders in medicines’ importing companies. The participants were selected randomly. 89% of respondents considered the medicines on the Sudanese market are generally of good quality. The design of the research itself may be considered inadequate with regard to selection process. However, the authors believe it provides enough evidence, and the current pharmaceutical regulations have some loopholes. The Pharmacy, Poisons, Cosmetics and Medical Devices Act-2001 and its regulation should be enforced. The overall set-up including the Act itself needs to be revised. The emerging crisis in pharmacy human resources requires significant additional effort to gather knowledge and dependable data that can inform reasonable, effective, and coordinated responses from government, industry, and professional associations. Furthermore research should be carried out to understand the scope, magnitude directions of the migratory flows, within and outside the country, as well as the characteristics and skills of the emigrated pharmacists.
Understanding the World of Industry and Business from the Perspective of Career Guidance and Counseling
Authors: Korompot Salim , Wantu Tuti , Alwi Nurul Maulida
Published: September 2022

The purpose of this research is to understand the world of industry and business (IDUKA) which is indispensable as a basis for increasing individual competence when entering the career world. Career guidance and counseling in this context aims to provide an understanding of several theories and competencies that must be improved, so that each individual can develop optimally in today's changing times to be more advanced. The current research method is a literature review study, which is a written summary of several studies and articles from journals, books and several career theories and information that have been reviewed. Although career guidance and counseling is not the only solution to provide an understanding of preparation to enter the world of industry and business, career guidance and counseling services can open up horizons of thinking as basic knowledge for the world of industry and business that can be understood.
Group Guidance Services with Self-Management Techniques to Reduce Students' Verbal Aggressive Behavior
Authors: Neviyarni S  , Novita Rita
Published: September 2022

The increase in students' verbal aggressive behavior every year must be eliminated or reduced in order to have a positive impact. One of the efforts made to reduce students' verbal aggressive behavior at school is to carry out group guidance services with self-management techniques. This study aims to describe the differences in student aggressive behavior with the experimental group guidance service using self-management techniques and the control group guidance service without using self-management techniques. This study uses a Quasi Experiment with The Non Equivalent Control Group design. The results showed that there was a significant difference in the aggressive behavior of experimental group students who were given group guidance services using self-management techniques with control group students who were given group guidance services without using self-management techniques; this can be seen in the average posttest score of the experimental group dropped higher than the average posttest score of the control group. Thus, group guidance services use self-management techniques effectively to reduce students' verbal aggressive behavior.
Psychometric Analysis Instruments of Self-efficacy in Work
Authors: Amalianingsih Restu , Herdi
Published: September 2022

The purpose of this study was to determine the Self-efficacy of students in their ability to achieve a certain level in the context of work. Respondents in this study were 234 students of class XII Vocational High School in Tangerang City. The sampling technique used in this research is non-probability sampling with the snowball sampling method. Researchers distributed online questionnaires through Google Forms to student representatives from several class XII Vocational High School in various schools. The instrument used in this study was the Work Self-efficacy Scale (WSES). This scale consists of a total of 10 items with 2 dimensions, namely Relational Willingness and Commitment. The results of the study, this Work Self-efficacy instrument can be declared reliable and valid. It is said to be reliable or consistent because in the third test, the calculation results obtained a Cronbach alpha reliability coefficient value of 0.874. The coefficient value is greater than the standard parameter, namely 0.7. This means that this instrument can be used repeatedly and can produce a consistent picture of Work Self-efficacy.
Pengaplikasian Pendidikan Berkarakter Melalui Belajar Daring di Masa Covid-19
Authors: Syarifah Syarifah , Wulan Rati , Triani Ria , Hamidah Triwanda , Zatrahadi M. Fahli
Published: September 2022

Belajar Daring merupakan suatu tingkatan untuk mencapai suatu keberhasilan atau tercapainya sasaran karena adanya suatu proses yang dilakukan oleh seseorang atau sebuah organisasi untuk bisa mencapai target yang diinginkan. Belajar Daring bagi muridnya supaya sasaran dalam mencapai tujuan belajar mencapai keberhasilan bagi muridnya supaya tetap mendapatkan ilmu dan paham akan materi yang disampaikan. Pandemi Covid 19 merupakan masalah global, menimbulkan berbagai dampak yang besar terutama dalam pendidikan. Belajar daring merupakan salah satu proses belajar yang sudah menjadi ketetapan di masa pandemi ini. Pendidikan Berkarakter ialah usaha yang sadar untuk merubah serta meningkatkan sikap seorang kearah yang baik supaya bisa bermasyarakat serta dapat menyatu di kehidupan masyarakat sehingga partisipan didikan  tidak terbawa- bawa pada hal- hal yang kurang baik.
Efektivitas Teknik Mind Mapping Dalam Layanan Bimbingan Kelompok Untuk Meningkatkan Kemampuan Perencanaan Karir Siswa
Authors: Julia Julia , Afandi Muslim
Published: September 2022

This research was instigated by the low of student career planning ability at State Senior High School 1 Kubu Rokan Hilir. It aimed at knowing student career planning ability, the implementation of Mind Mapping technique on Group Guidance service, and the effectiveness of Mind Mapping technique on Group Guidance service in increasing student career planning ability at State Senior High School 1 Kubu Rokan Hilir.  Quantitative approach was used in this research, and it was an experimental research with one-group pretest-posttest design.  Questionnaire, observation, and documentation were the instruments of collecting the data.  Wilcoxon test was used to analyze the data.  The research findings showed that student career planning ability before being given Mind Mapping technique on Group Guidance service was on low category and the mean was 51.  After being given Mind Mapping technique on Group Guidance service, it increased to high category and the mean was 81.  So, it could be known that there was a difference between pretest and posttest.  It could be concluded that Mind Mapping technique on Group Guidance service was effective in increasing student career planning ability, it could be seen from the probability score of Sig. (2-tailed) 0.005 that was lower than 0.05, so Alternative hypothesis was accepted.
OPTIMALISASI RETRIBUSI PELAYANAN PASAR UMUM KABUPATEN BLITAR
Authors: Susilo Susilo
Published: September 2022

Potensi sektor yang dapat meningkatkan Pendapatan Asli Daerah (PAD) di Kabupaten Blitar adalah pasar umum. Hal ini disebabkan karena penerimaan retribusi pelayanan pasar umum di Kabupaten Blitar mempunyai kontribusi yang cukup besar terhadap total penerimaan retribusi. Namun, penerimaan retribusi yang selama ini diperoleh belum optimal akibat adanya permasalahan dari sisi internal maupun eksternal. Berdasarkan hasil analisis menggunakan ATP dan SWOT, diperoleh strategi utama untuk mengoptimalkan penerimaan retribusi pelayanan pasar yakni (1) melakukan pembinaan terhadap petugas retribusi mengenai pemahaman tarif (2) menerapkan sistem e-retribusi (3) menaikkan tarif retribusi untuk pedagang yang mempunyai kemampuan membayar lebih tinggi dari tarif resmi (4) menurunkan tarif retribusi untuk pedagang yang mempunyai kemampuan membayar lebih rendah dari tarif resmi (5) mencetak karcis retribusi dengan besaran nominal yang sesuai dengan perda yang berlaku (6) melakukan revitalisasi pasar (7) melakukan sosialisasi kepada pedagang agar memiliki sikap disiplin dalam mentaati peraturan pasar pagi dan pasar siang, dan (8) melakukan sosialisasi kepada petugas retribusi agar tertib memberikan karcis kepada pedagang.
PDRI DALAM KARYA SENI LUKIS
Authors: Andika Putra Emasyah , Erfahmi Erfahmi
Published: September 2022

The purpose of this painting with the PDRI idea is to visualize a heroic event that is starting to be forgotten. The method of creating painting works through stages (1) Preparation, (2) Elaboration, (3) Synthesis, (4) Realization of concepts, and (5) completion. Ten paintings about heroic events of PDRI were created. The whole work tells about the synergy between the community guerrillas and the PDRI to expel the Dutch and gain Indonesian sovereignty. This painting is an interesting medium to identify the history of PDRI. Besides, this work is also expected to be a motivation in appreciating the history of the Indonesian nation.Keywords: PDRI, Indonesian Republic,art painting