bluuebunny/crossref_metadata_2025 huggingface dataset:
MODERN CONCEPTUAL FRAMEWORK OF THE COSMIC SPACE CATEGORY
Authors:   Taras Shevchenko National University of Kyiv, Ukraine, Klymenko Lada , Yuzva Solomiya ,   Taras Shevchenko National University of Kyiv, Ukraine
Published: March 2023

The article is devoted to the cosmic space category and its semantic meaning peculiarities. The interpretation of culture as a horizon of universal, that is, cosmic values, for all hours, was tied to the Cosmos. The national and cultural specificity of the cosmic space category was analyzed and its general characteristics were outlined. Also, the stages of the historical evolution of the studied category were profoundly focused. Given the results of the analysis the paper outlines the historical semantic shift and semantic expansion of this category. The vocabulary representing the concept was also structured. Medieval hymns that take their roots in folklore and folk epos turned out to be fruitful material for studying both linguocultural and worldview representations of the cosmic space category through the prism of the world's perception of that particular time. Cosmological works of different time periods and modern scientific articles were used as reference corpus material for this particular research. The problems of reconceptualization and refiguration of the category of space were researched in the modern national worldview. Also, the difference between the nominative fields and their lexical realization of both concepts ESPACE and COSMOS were described, and the “historical layers’’ and their change of these two concepts were determined. The semantic field of the cosmic space category has significantly expanded and is characterized by the presence of multiple plans. It has a lot of different new meanings, including the reinterpretation of the cosmic space category in terms that can be attributed to the semantic fields of economic space, safety space, resource space.
Assessing the Impact of Soiling, Tilt Angle, and Solar Radiation on the Performance of Solar PV Systems
Authors: Nwokolo Samuel , Obiwulu Anthony , Amadi Solomon , Ogbulezie Julie
Published: March 2023

This research examined the observed datasets and a theoretically derived model for estimating yearly optimum tilt angle (β), maximum incident solar radiation (Hmax), clean gain indicator (CGI), and soiling loss indicator (SLI) at Mumbwa, Zambia, the Mediterranean Region, and low latitude locations across the globe. The cleaned tilted collector emerged as the best performing collector due to Hmax and much higher energy gains compared with the soiled collector. CGI showed an appreciable performance of 0.4737% over -0.4708% on the SLI, indicating that soiling on the surface of photovoltaic (PV) modules significantly depreciates the overall performance of PV modules. Two established empirical models obtained from the literature were compared with the established theoretical model (β=φ). The result revealed that the two models overestimated the observed annual optimum tilt angle in this paper, simply because the models were developed with high latitude location datasets from the Asia continent. However, the newly established monthly and yearly global radiation indicator (GRI) models by the authors in their previous paper performed excellently in the selected representative cities in the Mediterranean region.
Investigation of Solid Formation Enthalpy and Molecular Mechanics Energies of Amino Acids via Force Field Approach
Authors: SONGUR Levent , ORHAN Oguzhan , OZGEN Soner
Published: March 2023

Accurate determination of the thermodynamic and molecular mechanical properties of amino acids will contribute to a better understanding of their folding mechanisms. In this study, the enthalpy values and molecular mechanics parameters of 17 amino acids were investigated by the classical molecular dynamics method. All calculations were performed using the force-field potential approach. As a result, the calculated solid formation enthalpy for ALA, ASN, ASP, CYS, LYS, and PHE are in good agreement with the experimental data. In addition, molecular mechanics parameters such as Coulomb, bond, angle, dihedral, and Van der Waals were calculated for all amino acids. It is seen that the Coulomb energy is quite low compared to the rest of the molecular mechanical energies. The molecular mechanical energies obtained from the study will contribute to protein-lipid modification studies for electronic interaction, ligand binding to the cell surface, and correct protein localization.
Topological Hoarded Graphs
Authors: POLAT Kadirhan
Published: March 2023

In this paper, we first introduced the steps to be taken to get the set-family corresponding to a hoarded graph, and an example implementation of these steps. We then give the notion of topological hoarded graph and show when a set-family induced by a topological hoarded graph is a topology on a set. We also present some useful facts about topological hoarded graphs.
Determining and Spatial Analysis Biogas Energy Potentials from Agricultural - Animal Wastes in Isparta, Turkey
Authors: KUMAŞ Kazım , HEPDENİZ Kerem , AKYÜZ Ali Özhan
Published: March 2023

Increasing energy need poses various problems in terms of energy supply security and environmental aspects for many countries. Therefore, energy policies are an important part of sustainable development plans, especially in developing countries. Turkey is one of the developing countries and its need for energy is increasing day by day. In Turkey, which generally meets its energy needs from fossil fuels, it is very important both economically and environmentally to reduce the use of these fuels, which are harmful to the environment and depend on foreign sources, and to use renewable energy sources. Considering Turkey's potential in renewable energy resources, the energy production efficiency to be obtained from the investments to be made is quite high. In this study, a numerical map was created by determining the biogas and energy potentials that can be obtained depending on the agricultural and animal wastes of the province of Isparta, Turkey. In determining the energy potential, 2018 agricultural and animal statistics of the Turkish Statistical Institute were used. In the calculation made for the province of Isparta, a total of 25831264.2 m3/year of biogas can be obtained from animal wastes and the thermal value of this value is 586369.70 GJ/year and the total energy potential that can be obtained from some agricultural wastes is calculated as 3549790.42 GJ/year.
Determination of resistance against the transmission of charged particles of Rhenium-Boron (Re-B) based alloys
Authors: AYGÜN Murat
Published: March 2023

In this study, the resistance of the Rhenium-Boron (Re-B) based alloys against the transmission of charged particles such as electron, proton, alpha, carbon and oxygen was investigated using the stopping power as the characterizing quantity. For this, the collision, radiative/nuclear, total stopping powers and projected range of the charged particles in the Re40-B60, Re50-B50, Re58-B42 and Re60-B40 alloys were calculated using the ESTAR, and the the Stopping and Range of Ions in Materials (SRIM) Monte Carlo code. It was found that the stopping powers of the heavy charged particles tended to decrease with increasing the rhenium concentration. These results suggest that the boron element is more suitable for heavy charged particle shielding materials compared to rhenium element.
Mathematical Modelling of CO2 corrosion with NORSOK M 506
Authors: DOĞAN Begüm , ALTINTEN Ayla
Published: March 2023

The consequences of corrosion is catastrophic also costs reached the global economy “$2.5 trillion, or world GDP’s 3.4%”. Despite the magnitude of the corrosion cost, it can be concluded that scientific studies on corrosion prevention are quite limited, with the exception of high-risk sectors such as aviation and the fuel oil industry. It is important to fight against corrosion in order to ensure the safe operation of oil-carrying pipelines under the sea; and to prevent accidents and environmental damage. As a result of developing industry conditions and increasing needs, modelling corrosion is a very effective method in the prevention of corrosion. Industry, research companies and universities have developed many corrosion rates, prediction models. One of them is the NORSOK M 506 model. In this study, the NORSOK M 506 CO2 corrosion prediction model and the experimental results conducted by Nešić, Solvi and Enerhaug in 1995 were compared in terms of CO2 corrosion rate. The results showed that the mathematical corrosion model calculated nearly six times higher than the experimental study within conformity.
Snow Avalanche Risk Assessment using GIS-Based AHP for Bitlis Province
Authors: AYDIN Mehmet Cihan , SEVGİ BİRİNCİOĞLU Elif , ULU Ali Emre , BÜYÜKSARAÇ Aydın
Published: March 2023

Bitlis province, located in the Eastern Anatolia of Turkey, is the region with the highest snowfall in the country. Due to its highland and steep structure, the region is under high avalanche risk. Assessment of the snow avalanche risks is important in terms of modern disaster management. In this study, the avalanche risks were assessed by using the analytical hierarchy process (AHP), which is an effective multiple criteria decision-making methods. The avalanche risk was considered depend on many factors such as temperature, slope, elevation, aspect, land use, soil, lithology, precipitation, distance to fault and population. The outputs obtained from the method were mapped in the GIS environment and thus the avalanche risks of the region were determined. According to the results, especially the highland and steep southern parts and the two volcanic mountain foothills in the region were evaluated as high risk. The study results were validated by comparing past avalanche events and some previous researches.
Commercial Lighting Design in Human-Centered Lighting Concept
Authors: PARLAKYILDIZ Şakir
Published: March 2023

In this study, the lighting design of a building in the Organized Industrial Zone, which was converted from a warehouse to a commercial kitchen, was designed according to the Human-Centered Lighting concept. Point lighting calculations were made for commercial kitchen environments with artificial lighting. In order to reduce the negative effects of lighting on human health, lighting that will not disrupt the circadian rhythm should be provided. By using direct lighting, without changing the architectural design, it has been tried to provide optimum lighting suitable for human biology with low-cost artificial lighting arrangements. According to WELL standards, an average of at least 500 lux conditions should be provided in the relevant work area on counters and other food preparation or production areas in Commercial Kitchen Lighting. This area, which was designed as a warehouse for this purpose, was designed as a commercial kitchen in terms of lighting. As a result of the design, a lighting design was made in accordance with the WELL standards according to the Human-Centered Lighting concept. In this way, the visual comfort of the working personnel is improved and optimum circadian effects are provided.
Development of Oleuropein Incorporated Chitosan Films for Antioxidant Active Food Packaging Applications
Authors: AYDOĞDU Ayça , KAYA Fatmagül
Published: March 2023

Oleuropein is the major phenolic component of olive leaf extract. In the present study, oleuropein was incorporated into chitosan films and the physical properties and antioxidant activity of films were determined. Chitosan to oleuropein ratio was arranged as 1:1, 1:0.5, 2:1, 2:0.5. Physical properties including moisture content, density, solubility, water vapor permeability, color and opacity were measured. The results showed the addition of oleuropein improved water vapor barrier and decreased solubility of chitosan films. The density and moisture content of the oleuropein added films were found similar with chitosan films. Oleuropein incorporation resulted in higher opacity and b* values whereas a* and L* values decreased. Chitosan films with oleuropein showed strong antioxidant activity. Films at chitosan/oleuropein ratio as 1:1 could be good candidate for active packaging material due to exhibiting good water vapor barrier, opacity and antioxidant property.
Computational Prediction of Interactions Between SARS-CoV-2 and Human Protein Pairs by PSSM-Based Images
Authors: ÖZGER Zeynep Banu , ÇAKABAY Zeynep
Published: March 2023

Identifying protein-protein interactions is essential to predict the behavior of the virus and to design antiviral drugs against an infection. Like other viruses, SARS-CoV-2 virus must interact with a host cell in order to survive. Such interaction results in an infection in the host organism. Knowing which human protein interacts with the SARS-CoV-2 protein is an essential step in preventing viral infection. In silico approaches provide a reference for in vitro validation to protein-protein interaction studies by finding interacting protein pair candidates. The representation of proteins is one of the key steps for protein interaction network prediction. In this study, we proposed an image representation of proteins based on position-specific scoring matrices (PSSM). PSSMs are matrices that are obtained from multiple sequence alignments. In each of its cells, there is information about the probability of the occurrence of amino acids or nucleotides. PSSM matrices were handled as gray-scale images and called PSSM images. The main motivation of the study is to investigate whether these PSSM images are a suitable protein representation method. To determine adequate image size, conversion to grayscale images was performed at different sizes. SARS-CoV-2-human protein interaction network prediction based on image classification with siamese neural network and Resnet50 was performed on PSSM image datasets of different sizes. The accuracy results obtained with 200x200 size images and siamese neural network as 0.915, and with 400x400 size images and Resnet50 as 0.922 showed that PSSM images can be used for protein representation.
Computational Thermal Analysis of Divergent and Convergent Flow Channels for Cooling Plates in PEM Fuel Cells
Authors: ACAR Mahmut Caner
Published: March 2023

During the operation of polymer electrolyte membrane fuel cells excess heat is generated as a result of electrochemical reactions. This heat raises the temperature of the polymer electrolyte membrane fuel cells, which can damage the membrane. Homogeneity of the temperature through the fuel cell is important in terms of stability and performance. Thermal management is therefore essential and is provided by the cooling channels formed on the bipolar plates or cooling plates. In this paper, a three-dimensional computational analysis of the cooling plate with divergent and convergent flow field designs is carried out. In this context, heat transfer and fluid flow performances of these two different flow fields are considered in terms of temperature uniformity, maximum temperature and pressure drop. Numerical results demonstrated that the more uniform temperature distribution along the fuel cell could be achieved with divergent flow field design. Furthermore, when a divergent design is used, the maximum surface temperature of the cooling plate and the pressure drop between the inlet and outlet of the channel are reduced.
Application of the Taguchi and ANOVA Methods to Optimize Ventilation Parameters for Infection Risk Based on the Wells-Riley Model
Authors: YÜCE Bahadır Erman
Published: March 2023

The coronavirus pandemic has caused many deaths and affected societies with social and economic problems as a consequence of its effect. Many different measures were taken to stop or reduce the spread of the virus like wearing a face mask and reorganizing school activities, transportation, and meetings. As an alternative to these measures, ventilation is a critical engineering solution that can help reduce the infection risk in the indoor environment. In this study, the effects of ventilation parameters (volume, ACH) and breathing rates on the Wells-Riley method-based infection risk probability were investigated by the Taguchi method. The orthogonal array was used to create the experimental design. Then, each parameter was analyzed according to the performance criterion (infection risk probability) using signal-to-noise (S/N) ratios and the order of importance of the parameters was calculated. Consequently, these data were used to identify worst-case and best-case scenarios to minimize the risk of infection in the indoor environment.
CONSTRUCTING RELATIONAL AND VERIFIABLE PROTEST EVENT DATA: FOUR CHALLENGES AND SOME SOLUTIONS*
Authors: Oliver Pamela , Hanna Alex , Lim Chaeyoon
Published: March 2023

We call for a relational approach to constructing protest event data from news sources to provide tools for detecting and correcting errors and for capturing the relations among events and between events and the texts describing them. We address two problems with most protest event datasets: (1) inconsistencies and errors in identifying events and (2) disconnect between data structures and what is known about how protests and media accounts of protests are produced. Relational data structures can capture the theoretically important structuring of events into campaigns and episodes and media attention cascades and cycles. Relational data structures support richer theorizing about the interplay of protests and their representations in news media discourses. We present preliminary illustrative data about Black protests from these new procedures to demonstrate the value of this approach.
Comparison of serum albumin level and lactate for predicting preterm morbidities and mortality
Authors: ELATAŞ Aygül , GÜLAŞI Selvi , MERT Mustafa Kurthan , KALE ÇEKİNMEZ Eren , TOLUNAY Orkun
Published: March 2023

Purpose: We aimed to comparison of serum albumin and lactate level for predicting neonatal morbidities and mortality in preterm infants < 32 weeks of gestation.

Materials and Methods: The medical records of babies were retrospectively analyzed. Patients were divided into three groups; plasma albumin levels ≤ 2.5 g/dL were defined as Group 1, 2.6-3 g/dL as Group 2 and ≥ 3 g/dL as Group 3. The babies < 28 weeks of gestation were analysed as a subgroup.

Results: 300 infants with mean gestational age of 28.7 ± 2.4 weeks and mean birth weights 1240 ± 405 grams were included. In predicting mortality; the sensitivity of the albumin level within the first three days was 74.4% and the specificity was 73.2% (cut-off < 2.9 g/dL), the sensitivity of the lowest albumin level was 90.7% and the specificity was 70.1% (cut-off < 2.65 g/dL), the sensitivity of the lactate level was 67.4% and the specificity was 63.3% (cut off > 3.1 mmol/L). Analysis of < 28 weeks babies; the sensitivity of lowest albumin level was 80% and the specifity was 66.7% (cut-off < 2.45 g/dL) and the sensitivity of the albumin level within the first three days was 74.3% and the specificity was 72.6% (cut-off < 2.8 g/dL), and the sensitivity of lactate was 74.3% and the specifity was 64.2% (cut-off > 3.1mmol/L).

Conclusion: Low serum albumin level appears to be more specific and sensitive than lactate in predicting mortality and may be considered to be added to mortality prediction scores.
Use of methacoline challenge test to detect bronchial hyperresponsiveness in children with persistent rhinitis
Authors: USTA GÜÇ Belgin , ASİLSOY Suna
Published: March 2023

Purpose: The incidence of persistent rhinitis in childhood is increasing day by day. Since bronchial hyperreactivity (BHR) and asthma can also be seen in a significant proportion of patients with persistent rhinitis, the use of markers that may indicate the risk of developing asthma in these patients is very important in clinical follow-up. In this study, it was aimed to demonstrate the relationship between persistent rhinitis and asthma in childhood using the bronchial methacoline challenge test (BMCT) and to investigate other factors associated with the risk of developing asthma in patients with persistent rhinitis.

Materials and Methods: Patients aged 6-18 years who presented with findings of persistent rhinitis were evaluated with a detailed history, physical examination, and spirometry. Patients with normal examination findings and spirometry findings, and patients whose examination findings and nasal inflammation findings were compatible with moderate-to-severe rhinitis were included in the study, and their atopy status was evaluated by skin prick test, and their BHR was evaluated by BMCT.

Results: Seventy-three patients were included in the study. The mean age was 9±2.7years, 45.2% of the patients were male. 63% of the patients were allergic and family history of allergy was present in 45.2% of the patients. 82.2% of the patients had BHR detected with BMCT. The median blood eosinophil count (BEC) was 320/mm3 and the IgE level was 160kU/L. Patients with atopy had statistically significantly higher IgE and BEC values compared with non-allergic patients. Patients with BHR were found to be younger, and had higher median BEC values. In multivariant analysis, it was observed that the patient's age300/mm3, and IgE levels>250IU/L increased the probability of detecting BHR with BMCT.

Conclusion: Care should be taken for every patient with persistent rhinitis because of the risk of BHR and asthma. Atopy examinations should be performed, but the possibility of developing BHR and asthma should not be overlooked even in the patients who are non- allergic.
Identification of variations in genes encoding ATP-dependent potassium channel proteins in patients with primary Raynaud's phenomenon
Authors: AKKAPULU Merih , YILDIRIM Metin , VEZİR Özden , SUCU Nehir , YALIN Ali
Published: March 2023

Purpose: Primary Raynaud’s phenomenon (PRP) is a vascular disorder characterized by recurrent vasospastic response of the fingers and toes to cold or stress. ATP-sensitive potassium (KATP) channels are widely distributed in vasculatures, and play an important role in the vascular tone regulation. The major vascular isoform of KATP channels is composed of Kir6.1/SUR2 (KCNJ8/ABCC9). It would be important to determine whether variations of KATP genes related to PRP is thought to be associated with vasospasm. It is believed that the studies describing mechanisms involved in the pathogenesis of inherited vascular disorders offers the best opportunity for investigation of the early stages of pathogenicity and diagnosis of PRP and associated other diseases. In this study we aim to investigate possible association between genetic variations observed in KATP channel coding genes and vasospasm associated with PRP.

Materials and Methods: In our study; the cases with PRP, the relation between the variation in the KCNJ8/ABCC9 genes (S422L/V734I or rs72554071/rs61688134) was examined. 50 subjects who were diagnosed with PRP (patient group) and 50 healthy subjects (control group) were included in the study. Variations were determined using the Tetra-Primer Amplification Refractory Mutation System-Polymerase Chain Reaction (T-ARMS PCR) method.

Results: Of the individuals in the patient and control group included in the study, 21 were male and 29 were female. The mean age of the patients was 25.7±3.36 years, and the mean age of the control group was 25.9±3.44 years. No significant relationship was found between PRP disease and genotype and allele distribution of KCNJ8/ABCC9 genes.

Conclusion: This study presented the first findings about KCNJ8/ABCC9 gene variations in the Turkish population and may lead to future studies. Studies involving a higher number of cases and more mutations will be able to show whether there is a relationship between KATP channels and PRP and contribute to the elucidation of PRP pathogenesis in terms of genetic factors.
The effects of hydrogen peroxide and mitochondria on human breast cancer cells
Authors: ÇİÇEK Zehra
Published: March 2023

Purpose: It was aimed to evaluate the effect of hydrogen peroxide (H2O2), mitochondria isolated from human breast cancer cells (MCF-7) and human mesenchymal stem cells (IMSCs) on MCF-7 cell proliferation in this study.

Materials and Methods: Mitochondria of IMSCs and MCF-7 cells were isolated according to the protocols specified in the kit and the protein amount of mitochondria was measured by the bicinchoninic acid method (BCA). H2O2 doses (0-1000 µM), mitochondria obtained from MCF-7 and IMSCs were transferred to MCF-7 cells and the viability was evaluated by tetrazolium salt (MTT) method. The cell percentages were calculated by measuring absorbance of the samples at 570 nm with a plate reader.

Results: It was found that, ATP level of the mitochondria isolated from IMSCs was higher than MCF-7s. MCF-7 cell viability decreased significantly in 30 µM (%19), 40 µM (%26), 50 µM (%39), 75 µM (%39), 100 µM (%36), 200 µM (%28), 400 µM (%23), 800 µM (%22) and 1000 µM (%23) H2O2 doses. The transfer of IMSCs mitochondria caused a tendency to decrease in cell proliferation, but no significance was detected. But, it was found that healthy mitochondria transfer with 10 µM and 1000 µM H2O2 reduced the proliferation of MCF-7s (respectively %14 and % 8).

Conclusion: It was determined that the transfer of healthy mitochondria isolated from IMSCs and H2O2 to MCF-7 is associated with proliferative processes, however transplantation of the healthy mitochondria into cancer cells is thought to be a promising new method in the treatment of the disease.
Total fertilization failure in intracytoplasmic sperm injection: a retrospective comparative study
Authors: İNAL Hasan , OZTURK INAL Zeynep
Published: March 2023

Purpose: The aim of this study was to evaluate total fertilization failure (TFF), embryo transfers following TFF cycles, and recurrent TFF, and to define the factors that might cause TFF.

Materials and Methods: Cycles that resulted in TFF (group 1, n=109), embryo transfers after TFF cycles (group 2, n=30), and cases of recurrent TFF (group 3, n=15) were evaluated retrospectively.

Results: Peak estradiol was higher in group 2 than other groups, and the rate of sperm morphology below 4% was lower in group 2 when compared to groups 1 and 3. The total numbers of retrieved oocytes (5.3±4.1 vs 10.2±1.5 (Odds Ratio=1.639; 95% CI 1.267-2.122)) and MII oocytes (2.9±2.2 vs 6.8±1.8 (Odds Ratio=2.218; 95% CI 1.529-3.216)) were significantly higher in embryo transfer cycles when compared to previous TFF cycles. Retrieved and MII oocytes counts were higher in group 2 with a median fertilization rate of 46.42% when compared to groups 1 and 3.

Conclusion: With more retrieved and MII oocytes, normal sperm morphology can increase the fertilization rate of ICSI cycles following earlier TFF.
Relocation of earthquakes in the Cook Inlet area, south central Alaska, using the joint hypocenter determination method
Authors: Ratchkovsky Natalia A. , Pujol Jose , Biswas Niren N.
Published: March 2023

The Joint Hypocenter Determination (JHD) method was used to relocate 1604 earthquakes that occurred during 1988 to 1993 in the Wadati-Benioff zone (WBZ) beneath the Cook Inlet in south central Alaska. The study utilizes both P- and S-wave arrivals recorded by a recently improved regional seismic network, and it provides an improvement over previous studies. The JHD locations of the events allowed improved delineation of the geometry of the subducted slab and the detection of a double seismic zone within the WBZ in the 40- to 100-km-depth range. The JHD station corrections obtained correlate with the major surface geological features in the study area (slow-velocity sedimentary basins) as well as with crustal and mantle structure (high-velocity subducting slab and low-velocity anomalies beneath the active volcanoes). To investigate the dependence of the JHD relocation procedure on factors such as the hypocentral depths of the events used, the velocity model, the νp/νs ratio, and random and systematic errors in travel-time readings, synthetic travel times were calculated using an exact raytracing technique, a three-dimensional tomographic P-wave velocity model, the present network configuration, and the actual seismicity distribution. Then, the synthetic events were located with the JHD algorithm. The synthetic experiments showed that the JHD procedure is rather insensitive to the choice of plane-layered velocity model and νp/νs ratio, preserves relative hypocenter locations well, and can handle systematic and large random reading errors effectively.
Source parameters of the 15 November 1995 Border Town, Nevada, earthquake sequence
Authors: Ichinose Gene A. , Smith Kenneth D. , Anderson John G.
Published: March 2023

The November 1995 Border Town, Nevada, earthquake sequence occurred near the California-Nevada border approximately 20 km northwest of Reno, Nevada. The largest earthquake of the sequence (Mw = 4.5) was widely felt throughout the Reno-Sparks-Truckee region. This event occurred on a west-dipping high-angle fault at a depth of 14 km and shows dip-slip motion on a preferred fault-plane orientation of strike N10°E, dip 70° W, and rake −75°. We have relocated 27 aftershocks and one foreshock of the event using records from the local network and two portable digital instruments. The largest aftershocks also align along a N10°E trend and define the preferred fault plane. All of the aftershocks occur within a small volume with a 2- by 2-km horizontal extent and between depths of 10 and 14 km.

Simultaneous determination of M0, fc, and κ is made by fitting spectra using various starting models (i.e., initial Δσs and κ) based on an f−2 spectral shape. M0 ranges from 1018 to 1023 dyne × cm for 14 events and hypocentral distances were less than 15 km. We fit S-wave spectra with different starting models to test the stability of Δσs. The results show that Δσs and κ converged to different values depending on the starting model and the magnitude because of an attenuation-source dimension trade-off. For example, a model starting with a stress drop of 10 bars produced an average Δσs of 27 bars and an apparent scaling breakdown below Mw 3. Starting the search at 50 bars produced an average Δσs of 69 bars and no magnitude dependence. We cannot resolve any breakdown in self-similarity because we find plausible spectral models for all magnitudes where Δσs is nearly constant at 60 bars.

Seismograms of the four largest aftershocks, Mw 3.0 to 3.4, were deconvolved using smaller aftershocks as empirical Green's functions. Event radii estimated from the pulse widths yield stress drop averaging 34 bars, within the range of the frequency-domain results.
Estimation of slowness vectors and their uncertainties using multi-wavelet seismic array processing
Authors: Bear Lorie K. , Pavlis Gary L.
Published: March 2023

We have developed a new seismic array data processing method to produce slowness vector estimates and an objective measure of their uncertainties in the form of statistical confidence intervals. The slowness vector, which is typically transformed into bearing and velocity, is a key parameter used for identifying seismic phases and for event source location. Our method, multi-wavelet beamforming, is closely related to both time-domain and frequency-domain beamforming. The major advantage of multi-wavelet beamforming is that it produces multiple estimates of the slowness vector that are approximately statistically independent. First, a set of wavelet transforms is applied to the data in a manner analogous to the use of the windowed Fourier transform. Next, for each wavelet transform, we calculate semblance, a measure of signal coherence, for a range of possible slowness vectors. Then, the slowness vector estimate associated with that transform is the vector that produces the largest semblance value. The multiple slowness vector estimates can be treated as samples from a probability distribution, whose “center” we estimate using the mean, the median, and an M-estimator. Uncertainty intervals are calculated for these estimators by applying the jackknife statistical method. The intervals for the mean estimator appear to be true statistical confidence intervals, but the estimates can be biased by a directional noise field in low signal-to-noise circumstances. The median estimates are less biased by a directional noise field but sometimes underestimate the uncertainty. The M-estimator produces less-biased estimates while appearing to estimate correctly their uncertainty.
Are Social Work Students Being Adequately Prepared to Intervene With Suicide?
Authors: Mirick Rebecca G.
Published: March 2023

Suicide is a major public health issue in the United States, but it is unknown how many social work programs have courses specializing in this topic. The purpose of this study was to establish baseline knowledge of suicide-focused course offerings in social work programs in the United States. A survey of CSWE-accredited programs (n=151) in the United States was used to collect data on social work programs’ suicide content in their curricula at three levels: baccalaureate, graduate, and continuing education. While only 6% of programs offered a required course on suicide, 13.9% offered an elective focused on suicide, and courses with substantial suicide content were available in 25.2% of programs. Continuing education offerings with a focus on suicide were present at 26.5% of programs. The implications for social work education are discussed, including the need for more courses specializing in suicide, especially within MSW programs, and for future research to better understand the factors which limit the development of such courses.
Bioprinted Notch ligand to function as stem cell niche improves muscle regeneration in dystrophic muscle
Authors: Sun Zewei , Yue Xianlin , Liu Lei , Li Ying , Cui Jie , Li Dong , Weiss Lee , Campbell Phil , Mu Yanling , Huard Johnny , Mu Xiaodong
Published: March 2023

In Duchenne muscular dystrophy, dystrophic muscle phenotypes are closely associated with the exhaustion of muscle stem cells. Transplantation of muscle stem cells has been widely studied for improving muscle regeneration, but poor cell survival and self-renewal, rapid loss of stemness, and limited dispersion of grafted cells following transplantation have collectively hindered the overall success of this strategy. Optimized mechanisms for maintaining and improving stem cell function are naturally present in the microenvironment of the stem cell niche in healthy muscles. Therefore, one logical strategy toward improving stem cell function and efficiency of stem cell transplantation in diseased muscles would be the establishment of a microenvironment mimicking some key aspects of healthy native stem cell niches. Here, we applied inkjet-based bioprinting technology to engineer a mimicked artificial stem cell niche in dystrophic muscle, comprising stem cell niche regulating factors (Notch activator DLL1) bioprinted onto 3D DermaMatrix construct. The recombinant DLL1 protein, DLL1 (mouse): Fc (human) (rec), was applied here as the Notch activator. Bioprinted DermaMatrix construct was seeded with muscle stem cells in vitro, and increased stem cell maintenance and repressed myogenic differentiation process was observed. DLL1 bioprinted DermaMatrix construct was then engrafted into dystrophic muscle of mdx/scid mice, and the improved cell engraftment and progression of muscle regeneration was observed 10 days after engraftment. Our results demonstrated that bioprinting of Notch activator within 3D construct can be applied to serve as muscle stem cell niche and improve the efficacy of muscle stem cell transplantation in diseased muscle.
Hybrid solid mesh structure for electron beam melting customized implant to treat bone cancer
Authors: Park Jong Woong , Seo Eunhyeok , Park Haeum , Shin Ye Chan , Kang Hyun Guy , Sung Hyokyung , Jung Im Doo
Published: March 2023

Bone replacement implants manufactured by electron beam melting have been widely studied for use in bone tumor treatment. In this application, a hybrid structure implant with a combination of solid and lattice structures guarantees strong adhesion between bone and soft tissues. This hybrid implant must exhibit adequate mechanical performance so as to satisfy the safety criteria considering repeated weight loading during the patient’s lifetime. With a low volume of a clinical case, various shape and volume combinations, including both solid and lattice structures, should be evaluated to provide guidelines for implant design. This study examined the mechanical performance of the hybrid lattice by investigating two shapes of the hybrid implant and volume fractions of the solid and lattice structures, along with microstructural, mechanical, and computational analyses. These results demonstrate how hybrid implants may be designed to improve clinical outcomes by using patientspecific orthopedic implants with optimized volume fraction of the lattice structure, allowing for effective enhancement of mechanical performance as well as optimized design for bone cell ingrowth.
Revisión sistemática del comportamiento convencional y reológico del biocompuesto asfalto-biomasas producidas
Authors: Muñoz-Pérez Sócrates Pedro , Morante-Santamaría María Magaly , Huamán-Manayay Helmer Félix
Published: March 2023

La ingeniería de pavimentos, busca con ahínco materiales no petrolíficos como sustituyentes/mejoradores del asfalto. La producción de bioasfalto con biomasa es la técnica más usual con beneficios económicos, sociales y medioambientales. Este documento tiene como objetivo realizar una revisión literaria del mejoramiento del asfalto con biomasa en subproductos de biocarbón o bioaceite. Se efectuó una revisión de 80 artículos científicos, los cuales estudiaron las propiedades convencionales y reológicas del asfalto con porcentajes óptimos de adición de biomodificadores, considerándolos como nuevas tecnologías en las construcciones viales. Los resultados muestran que la dosis y tipo del biomaterial influye mucho como modificador, dado que el rendimiento del bioasfalto a base de biomasa garantiza reacciones positivas con una mínina adición de 1% de aceite de palma hasta 100% de ceniza de madera como máximo. En conclusión, a mayor dosis de biomodificador a altas temperaturas mayor es la mejora en la viscosidad, estabilidad, grado de penetración, punto de reblandecimiento, resistencia a la tracción indirecta, módulo de resistencia, resistencia a la deformación, resistencia a la fatiga, resistencia al deslizamiento y resistencia a la humedad del asfalto, además de tener mejores condiciones de envejecimiento oxidativo, pues generalmente el ligante asfáltico es compatible con la mayoría de los biomateriales, siendo viable como fuente de energía renovable, sostenible y de calidad.
A New Respiratory Diseases Detection Model in Chest X-Ray Images Using CNN
Authors: Avcı İsa , Alzabaq Ahmed
Published: March 2023

Convolutional Neural Network (CNN)-based deep learning techniques have recently demonstrated increased potential and effectiveness in image recognition applications, such as those involving medical images. Deep-learning models can recognize targets with performance comparable to radiologists when used with CXR. The primary goal of this research is to examine a deep learning technique used on the radiography dataset to detect COVID-19 in X-ray medical images. The proposed system consists of several stages, from pre-processing, passing through the feature reduction using more than one technique, to the classification stage based on a proposed model. The test was applied to the COVID-19 Radiography dataset of normal and three lung infections (COVID-19, Viral Pneumonia, and Lung Opacity). The proposed CNN model has shown its ability to classify COVID, normal, and other lung infections with perfect accuracy of 99.94%. Consequently, the AI-based early-stage detection algorithms will be enhanced, increasing the accuracy of the X-ray-based modality for the screening of various lung diseases.
Dimensionamento da força de trabalho na Atenção Primária à Saúde: modalidade de Ensino a Distância
Authors: Nascimento Elisabet Pereira Lelo , Jerônimo Eliane Barbosa , Godoy Joelma Silva Campos , Silva Solanyara Maria da
Published: March 2023

Este estudo pretende descrever a experiência da organização e desenvolvimento do curso de Qualificação para Profissionais da Atenção Primária à Saúde para o Dimensionamento da Força de Trabalho na Atenção Primária à Saúde (APS) acerca da compreensão dessa metodologia, no ambiente virtual de aprendizagem da Escola de Saúde Pública do Estado de Mato Grosso a partir da plataforma Moodle. A estrutura pedagógica adotada foi organizada em quatro Unidades de Aprendizagens (UA) com total de 80 horas, sendo os conteúdos programáticos correspondentes as quatro questões norteadoras da metodologia de dimensionamento da força de trabalho em saúde na APS. O processo formativo ocorreu entre outubro e dezembro de 2020, com a inscrição de 30 educandos, 8 (26,7%) cancelaram a matrícula e 22 (73,3%) iniciaram a capacitação, 2 (9,1%) abandonaram o curso, 2 (9,1%) foram reprovados por não concluírem as atividades e 18 (81,8%) finalizaram o curso com aprovação. O Ensino a Distância para conhecimento da metodologia do dimensionamento da força de trabalho em saúde na Atenção Primária à Saúde revelou ser uma inovação na área de gestão do trabalho em saúde, possibilitando ainda que o trabalhador da saúde possa participar do curso remotamente.
Mapeamento geográfico de hipertensos e diabéticos da cidade de Marabá, Pará
Authors: Costa Nathalia Lima , Araújo Matheus Sodré de , Oliveira Ana Karoline Brito de , Cunha Katiane da Costa
Published: March 2023

HIPERDIA é um programa do Ministério da Saúde que visa prevenir e tratar a Hipertensão Arterial e a Diabetes Mellitus. Nesse sentido, é importante compreender como o programa atua dentro de um território para que se possa entender o público que participa do HIPERDIA e em qual ambiente ele está inserido. Este trabalho tem por objetivo principal mapear os hipertensos e diabéticos participantes do HIPERDIA na cidade de Marabá-PA. Estudo transversal qualitativo realizado nas Unidades Básicas de Saúde de Marabá. Foram analisadas fichas de cadastramento do programa HIPERDIA utilizando teste Qui-quadrado e mapeamento no software QGIS. A amostra foi composta por 695 pacientes que em sua maioria eram mulheres, pardas e com ensino fundamental completo. Percebeu-se predomínio de sedentarismo e sobrepeso como fatores de riscos, enquanto a complicação mais comum foi o AVC. Sendo o núcleo da Velha Marabá o com maior número de cadastrados. É necessário que o programa HIPERDIA seja ampliado na cidade de Marabá, para que políticas de educação em saúde possam ser implementadas ainda mais no município.
Efeitos agudos e manifestações clínicas decorrentes do uso de cigarros eletrônicos
Authors: Sampaio Lucas Barbosa , Amorim Ana Beatriz Medeiros de , Oliveira Roberta Arruda de , Maniçoba Nickson Breno , Bachur Tatiana Paschoalette Rodrigues
Published: March 2023

Inicialmente desenvolvidos para auxiliar no tratamento do tabagismo, os dispositivos eletrônicos para fumar (DEFs), também conhecidos como cigarros eletrônicos, surgiram como uma alternativa teoricamente menos danosa à saúde do que os cigarros convencionais. No entanto, diversas condições médicas decorrentes da popularização do seu uso têm sido relatadas ao redor do mundo. Essa revisão se propõe a apresentar e discutir as complicações e efeitos agudos na saúde humana oriundas do uso dos cigarros eletrônicos. Para tal, realizou-se uma pesquisa bibliográficas nas bases de dados MEDLINE, EMBASE e Web of Science, através do uso de descritores apropriados, com a seleção de artigos publicados no período entre os anos de 2017 e 2021. A partir dos 207 estudos inicialmente recuperados nas bases, 20 foram selecionados para compor esse trabalho com base em critérios de inclusão e exclusão pré-estabelecidos. A literatura vigente traz a descrição de inúmeras manifestações clínicas associadas ao uso de DEFs, tais como: tosse persistente, falta de ar, epiglotite, exacerbação da asma, lesão por queimadura, trauma, pneumonias, morte, dentre outras. Além disso, também são relatadas alterações oriundas da inalação do vapor do cigarro eletrônico na fisiologia humana, principalmente nos sistemas nervoso, cardíaco e pulmonar. Verificou-se, pois, que os DEFs não são livres de riscos à saúde humana e, por esse motivo, seu uso deve ser regulamentado adequadamente pelos gestores de saúde pública.
Análise da violência doméstica contra mulher no Brasil e fatores determinantes
Authors: Silva João Paulo Lopes da , Morais Maria do Socorro Trindade
Published: March 2023

A violência doméstica contra a mulher é considerada atualmente um problema de saúde pública e uma violação dos direitos humanos. Este estudo tem por objetivo identificar os fatores determinantes que influenciam na violência doméstica contra mulher no Brasil. Trata-se de uma revisão integrativa da literatura, realizada nas bases de dados: SciELO, LILACS e PubMed. Foram incluídos artigos publicados em português, inglês ou espanhol, encontrados na íntegra, entre os anos de 2016 e 2020, na qual tivesse como cenário de estudo o Brasil. A amostra final foi composta por doze artigos. Os estudos evidenciaram que a violência psicológica em mulheres vítimas de violência doméstica foi mais prevalente em relação a física, moral e sexual. Fatores como questões socioeconômicas, a baixa escolaridade tanto de homens, como de mulheres, alcoolismo e outras drogas foram os determinantes mais prevalentes, estando relacionados com a ocorrência de violência física e psicológica. Faz-se necessário a ampliação de debates e de intervenções que possa quebrar o silêncio de uma problemática gritante na sociedade brasileira, para que ocorra a redução dos índices de mulheres vítimas da violência doméstica no país.
Terminalidade da vida do paciente: uma lacuna na formação dos médicos veterinários
Authors: Valério Giovanna Bauer , Viana Danilo Augusto Mendes , Feranti João Pedro Scussel , Beckmann Diego Vilibaldo , Teresa de Oliveira Marília Teresa de
Published: March 2023

Considerando a importância do cuidado com a saúde mental dos estudantes e médicos veterinários, o objetivo do estudo foi avaliar a percepção dos médicos veterinários sobre o preparo obtido sobre a terminalidade da vida do paciente durante a graduação de medicina veterinária e programas de residência. Médicos veterinários matriculados em programas de residência em área profissional da saúde no estado do Rio Grande do Sul (RS), Brasil, foram convidados a responder um questionário semiestruturado. Obteve-se a participação de 31,3% (N=42) dos profissionais, os quais representam um grupo de risco para o desenvolvimento de esgotamento saúde mental considerando o sexo, idade e tempo de formação. Os treinamentos formais relativos ao gerenciamenteo de emoções quanto óbito do paciente e prática da eutanásia não foram abordados durante a graduação de mais de dois terços dos respondentes, fato que preocupantemente também é observado durante a pós-graduação. Somente 11,9% (N=2)  relatam ter recebido treinamento durante a graduação para comunicar o óbito ao cliente e 9,5% (N=1)  durante a residência. O estudo evidenciou que os médicos veterinários atuantes nos programas de residência do Rio Grande do Sul, Brasil, não tiveram preparo durante a graduação nem durante a residência para lidar com o óbito dos paciente. . A inclusão desse treinamento formação do médico veterinário por meio de disciplinas específicas podem auxiliar na formação de profissionais mais preparados, minimizando o efeito psicológico atrelado.