bluuebunny/crossref_metadata_2025 huggingface dataset:
Price Competition in Five-Star Hotel Industry
Authors: Eko Atmadji  , Indra Putra Nugraha
Published: February 2023

Purpose – To analyze the characteristics of price competition in five-star hotel industry in DIY.

Method – Descriptive qualitative method in order to know the detail about price competition. In-depth interviews with market players as well as government and other stakeholders are conducted. To get the full picture, this study also interviewed to PHRI (Indonesian Hotel Union). The SCP theory (structure-conduct-performance) becomes the guidance of interview and analysis.

Findings – The results of this study indicate that the hotel market is loose oligopoly or close to the monopolistic nature, competition is quite strict considering frequent over supply within one year, and pricing strategy becomes more important. Every hotel often changes their price strategy to follow certain conditions in the market. In differentiating its products, each hotel implements different themes to attract the attention of the guests. In five-star hotels at DIY, price strategy has low impact to the customers’ satisfaction except for Eastparc Hotel.

Implication – This study implicates that the behavior of five-star hotels in DIY will make the competition become soft and create tacit collusion. This is not good news for below three-star rank hotels.

Originality – This study contributes to the price competition study especially in five-star hotel market.

 

Abstrak

Tujuan – Menganalisis karakteristik persaingan harga pada industri hotel bintang lima di DIY.

Metode – Metode kualitatif deskriptif untuk mengetahui secara detail tentang persaingan harga. Wawancara mendalam dengan pelaku pasar serta pemerintah dan pemangku kepentingan lainnya dilakukan. Untuk mendapatkan gambaran yang utuh, penelitian ini juga mewawancarai PHRI (Persatuan Hotel Indonesia). Teori SCP (struktur-perilaku-kinerja) menjadi pedoman wawancara dan analisis.

Temuan – Hasil penelitian ini menunjukkan bahwa pasar perhotelan bersifat oligopoli longgar atau mendekati sifat monopolistik, persaingan cukup ketat mengingat sering terjadi over supply dalam satu tahun, dan strategi penetapan harga menjadi lebih penting. Setiap hotel sering mengubah strategi harga mereka untuk mengikuti kondisi tertentu di pasar. Dalam membedakan produknya, setiap hotel menerapkan tema yang berbeda untuk menarik perhatian para tamu. Di hotel bintang lima di DIY, strategi harga berdampak rendah terhadap kepuasan pelanggan kecuali Hotel Eastparc.

Implikasi – Studi ini berimplikasi bahwa perilaku hotel bintang lima di DIY akan membuat kompetisi menjadi lunak dan menciptakan tacit collusion. Ini bukan kabar baik untuk hotel peringkat bintang tiga atau lebih rendah.

Orisinalitas – Studi ini berkontribusi pada studi persaingan harga terutama di pasar hotel bintang lima.
Analisis determinan aliran Foreign Direct Investment (FDI) di kawasan ASEAN
Authors: Fajar Nurbani Aslam  , Ari Rudatin
Published: February 2023

Purpose – To analyze the effect of inflation, Gross Domestic Product, interest rates, Human Development Index and trade openness on Foreign Direct Investment (FDI) to countries in the ASEAN region.

Methods – This study uses panel data for the 2010-2019 period in 7 (seven) countries in the ASEAN region.

Findings – The results showed that inflation, interest rates and the Human Development Index had no effect on FDI in ASEAN countries, while the Gross Domestic Product (GDP) variable had a positive effect on FDI and trade openness had a negative effect on FDI in ASEAN countries. The country with the highest FDI inflows is owned by Singapore, while the country with the lowest FDI inflows is owned by Indonesia.

Implication – Policies are needed to encourage the growth of Gross Domestic Product (GDP), the governments of each country in the ASEAN region need to regulate trade openness to increase FDI inflows.

Originality – This study focuses on the factors influencing FDI inflows to the 7 countries of the ASEAN region.

 

Abstrak

Tujuan – Untuk menganalisis pengaruh inflasi, Produk Domestik Bruto, suku bunga, Indeks Pembangunan Manusia dan keterbukaan perdagangan terhadap Foreign Direct Investment (FDI) ke negara di kawasan ASEAN

Metode – Penelitian ini menggunakan data panel periode 2010 – 2019 pada 7 (tujuh) negara di kawasan ASEAN

Temuan – Hasil penelitian menunjukkan variable inflasi, suku bunga, dan Indeks Pembangunan Manusia tidak berpengaruh terhadap FDI di Negara Kawasan ASEAN, sementara variabel Produk Domestik Bruto (PDB) berpengaruh positif terhadap FDI dan variabel Keterbukaan Perdagangan berpengaruh negatif terhadap FDI di Negara Kawasan ASEAN. Negara dengan aliran masuk FDI tertinggi dimiliki oleh negara Singapura, sedangkan negara dengan aliran masuk FDI terendah dimiliki oleh Indonesia.

Implikasi – Diperlukan kebijakan untuk mendorong pertumbuhan Produk Domestik Bruto (PDB), pemerintah tiap negara di kawasan ASEAN perlu mengatur keterbukaan perdagangan untuk meningkatkan aliran masuk FDI.

Orisinalitas – Penelitian ini fokus pada faktor-faktor yang mempengaruhi aliran masuk FDI ke 7 negara kawasan ASEAN.
Analisis faktor yang mempengaruhi tingkat pengangguran terbuka di Indonesia tahun 2015-2020
Authors: Putri Rianti Novia , Ash Shidiqie Jannahar Saddam
Published: February 2023

Purpose – This study aims to analyze the factors that influence the Open Unemployment Rate (TPT) in Indonesia in terms of Gross Regional Domestic Product (PDRB), Domestic Investment (PMDN), Foreign Investment (PMA), and Technology.
Methods – This study uses panel data for the 2015-2020 period in 34 provinces in Indonesia.
Findings – The results of this study indicate that the PDRB, PMA, and Technology have a negative effect on the Open Unemployment Rate. In contrast, PMDN does not affect the Open Unemployment Rate.
Implication – The results of this study recommend that policymakers in dealing with open unemployment in Indonesia are to formulate development policies and strategies to increase PDRB by optimizing sectoral economic approaches, facilitating licensing and creating a conducive investment climate for foreign investors, as well as increasing the development of information technology infrastructure and communication (TIK) in all provinces in Indonesia.
Originality – This research analyzes the factors affecting Indonesia's open unemployment rate.
Abstrak
Tujuan – Penelitian ini bertujuan untuk menganalisis faktor yang mempengaruhi Tingkat Pengangguran Terbuka (TPT) di Indonesia dari sisi Produk Domestik Regional Bruto (PDRB), Penanaman Modal Dalam Negeri (PMDN), Penanaman Modal Asing (PMA), dan Teknologi
Metode – Penelitian ini menggunakan data panel periode 2015-2020 pada 34 provinsi di Indonesia.
Temuan – Hasil penelitian ini menunjukkan bahwa PDRB, PMA, dan Teknologi berpengaruh negatif terhadap Tingkat Pengangguran Terbuka, sedangkan PMDN tidak berpengaruh terhadap Tingkat Pengangguran Terbuka.
Implikasi – Hasil penelitian ini merekomendasikan kepada pengambil kebijakan dalam menangani pengangguran terbuka di Indonesia adalah dengan membuat kebijakan dan strategi pembangunan untuk meingkatkan PDRB dengan mengoptimalkan pendekatan ekonomi sektoral, memudahkan perizinan dan menciptakan iklim investasi yang kondusif untuk investor asing, serta meningkatkan pembangunan infrastruktur teknologi informasi dan komunikasi (TIK) di seluruh provinsi di Indonesia.
Orisinalitas – Penelitian ini berkontribusi dalam menganalisis faktor yang mempengaruhi tingkat pengangguran terbuka di Indonesia.
Activation of Mast Cells by Neuropeptides: The Role of Pro-inflammatory and Anti-Inflammatory Cytokines
Authors: Lauritano Dorina , Mastrangelo Filiberto , D’Ovidio Cristian , Ronconi Gianpaolo , Caraffa Alessandro , Gallenga Carla E. , Frydas Ilias , Kritas Spyros K. , Trimarchi Matteo , Carinci Francesco , Conti Pio
Published: February 2023

Mass cells (MCs) are tissue cells that are derived from bone marrow stem cells that contribute to allergic reactions, inflammatory diseases, innate and adaptive immunity, autoimmunity, and mental disorders. MCs located near the meninges communicate with microglia through the production of mediators such as histamine and tryptase, but also through the secretion of IL-1, IL-6 and TNF, which can create pathological effects in the brain. Preformed chemical mediators of inflammation and tumor necrosis factor (TNF) are rapidly released from the granules of MCs, the only immune cells capable of storing the cytokine TNF, although it can also be produced later through mRNA. The role of MCs in nervous system diseases has been extensively studied and reported in scientific literature and is of great clinical interest. However, many of the published articles concern studies on animals (mainly rats or mice) and not on humans. MCs are known to interact with neuropeptides that mediate endothelial cell activation, resulting in central nervous system (CNS) inflammatory disorders. In the brain, MCs interact with neurons causing neuronal excitation with the production of neuropeptides and the release of inflammatory mediators such as cytokines and chemokines. This article explores the current understanding of MC activation by neuropeptides and the role of pro-inflammatory cytokines, suggesting a therapeutic effect of the anti-inflammatory cytokines IL-37 and IL-38.
Histopathological changes in Lithobates catesbeianus tadpoles used as biomarkers of pesticide poisoning
Authors: Marcantonio Adriana Sacioto , França Fernanda Menezes , Santos Diego Sales , Martins Ana Mara Cristina Rebello Pinto Fonseca , Hipólito Márcio , Schalch Sérgio Henrique Canello , Viariato Cristina , Ferreira Cláudia Maris
Published: February 2023

The use of biological indicators has increased in recent years with the aim of investigating environmental pollution in aquatic environments that are vulnerable to the constant use of pesticides. Some biomarkers can help assess the health status, indicating physical, metabolic, and behavioral changes under acute and sublethal poisoning. The mixture of the active ingredients cyproconazole and picoxystrobin is a widely used fungicide for the control of pests in cotton, rice, coffee, sugarcane, corn, soybean, and wheat. The objective of this study was to verify the occurrence of possible histopathological lesions in the liver and kidneys of bullfrog tadpoles (Lithobates catesbeianus) caused by a fungicide commercial formula composed of picoxystrobin and cyproconazole. The animals were subjected to different concentrations of the fungicide to determine the median lethal concentration (LC50-96h = 0.05 mg L-1), that is, the lethal dose for 50% of the animals in 96 h. After determining the value of LC50-96h, the animals were subjected to three sublethal concentrations (LC50-96h/2, LC50-96h/10, and LC50-96h/100). Through histological biomarkers, it was verified that this fungicide changed the morphology of the animals' kidney and liver tissues in a chronic way, impairing the functioning of organs that are essential for their survival and metamorphosis, which can result in an imbalance in the biodiversity of aquatic ecosystems.
EFFORTS TO IMPROVE THE EFFECTIVENESS OF LEARNING MODELS (A Case Study Using Faststone in Online Learning at SMK NEGERI 1 Juwiring)
Authors: Budianti Heni , Sarjana Sri
Published: February 2023

Online learning is learning process to gain knowledge through a set of electronic de­vices with relevant application programs and connected to internet. Teachers must develop vari­ous effective learning models during pandemic. Online learning needs to be done as long as there is no classroom learning, one program that can be applied is faststone. The purpose of study was to obtain overview effectiveness the implementation of online learning using faststone. The re­search subjects were students of class XI in financial accounting department totaling 69 students through data collection of observations, documentation, and giving questionnaires. Qualitative descriptive method was applied to analyze the collected data. Results showed that the application of learning model using faststone was more effective during online learning. Learning model used in this study can be applied by teachers to increase learning independence, interest and motivation, and courage to express ideas during online learning.
Creativity towards Design Based Learning in STEM Education
Authors: Nugroho Oktian Fajar , Permanasari Anna , Firman Harry , Riandi Riandi
Published: February 2023

Creativity is a key component in the last century skills and has been highlighted in curricular research globally especially in Indonesia. This research therefore aimed at analyzing and identifying perspectives of creativity by pre-service teachers when a likely solution step was generated in the DBL. Three separate design based learning activities were undertaken by 13 female and 11 male pre-service teachers. Two separate methods have been used for analysis of data gathered from pre-service teachers’ writings and drawings, half-structured interviews, and field notes. In quantitative study of pre-service teachers' works and in exploring the notions of creativity, fluency, flexibility, and originality. In this study descriptive analysis was used. In semi-structured interviews and field notes the findings of the descriptive analysis included quality anal­yses. Description analysis showed the highest showed in creativity and flexibility, but the lowest was originality. The findings of content analysis further showed a variety of factors influencing the uniqueness of pre-service teachers ideas including exposure of people to ideas, knowledge of design based learning and the prototyping of pre-service teachers' ideas. The study results might enhance the usage of DBL to help educators and researchers understand the strengths and limits of their pupils through the creativity and STEM education.
Analysis of Students’ Learning Style Preference Adaptation on Mathematics Learning during the Distance Learning Condition
Authors: Nugraha Trisna , Prabawanto Sufyani
Published: February 2023

Changes in the education system due to COVID-19 pandemic through distance learning (PJJ) have made it difficult to accommodate students’ needs in achieving mathematical proficiency. The needs of these students are based on students learning style preference (KGB), how students obtain information, as one of the determinants of success in learning mathematics. This study aims to investigate the extent to which each student’s KGB can adapt to the PJJ designed through RADEC (Read-Answer-Discuss-Explain-Create) and direct learning. A quasi-experimental study with 2 x 3 factorial designed was conducted involving 56 4th graders from a private elementary school in Bandung. The research instrument used was the KGB scale and mathematical conceptual understanding (MCU) test. The result of this study showed that there were differences in students’ MCU viewed by KGB during PJJ which was more accommodating to visual students. It is necessary to improve the PJJ design that accommodate each KGB.
Analysis of The Use of Google Classroom in Online Learning at Elementary School
Authors: Listiyani Istna , Wahyudi Wahyudi , Salimi Moh
Published: February 2023

This study aims to analyze the use of Google Classroom in online learning for class V at SD Negeri Kranggan in the Covid-19 era. This research uses a qualitative approach with a case study method. The data sources of this research were students and teachers of class V and the principal of SD Negeri Kranggan. Data collection techniques used are observation and interviews. Data analysis using triangulation techniques and sources. The results showed that the percentage of use of Google Classroom in online learning for class V was 81% with a good category. There are 5 of 7 Google Classroom features that have been used in online learning for class V SD Negeri Kranggan with the implementation of learning applying aspects of theexisting six aspects. This study concludes that the use of Google Classroom has utilized the five available features including assignment, grading, mobile application, privacy, and time-cost by implementing aspects of using Google Classroom including creating accounts, organizing classrooms, managing topics in the classroom, uploading materials, developing questions and make assessments.
Question Analysis in 11th Grade Chemistry Book in Term of Critical Thinking Indicators
Authors: Nugroho Imam Sri , Mulyani Sri , Susanti Elfi
Published: February 2023

This study aims to determine the indicators of critical thinking skills that developed in the questions that contained in the XI grade high school chemistry textbook and to determine the critical thinking level of the questions developed in the XI high school chemistry textbook. This study is a qualitative research using descriptive documentation analysis method or content analysis. The document that analyzed are questions in the chemistry textbook used by eleventh grade students at four Senior High Schools in Surakarta. The sampling technique that used is multistage sampling and data validation using observer triangulation. The results showed that the critical thinking indicators that appeared on the questions from the textbooks analyzed included basic clarification, appearing at 100%; bases for a decision appearing at 0%; inference appearing at 88.9%; Advanced clarification appearing at 38.9%; supposition and integration appearing at 31.5%; auxiliary ability appearing at 40.7%. Meanwhile, based on the Critical Thinking Level (TBK), the questions included in the TBK 0 group are 0%; TBK 1 are 29.6%; TBK 2 are 68.5%; TBK 3 are 1.8%.
Pablo González Casanova, historiador
Authors: González Herrera Carlos
Published: February 2023

La importancia de Pablo González Casanova como sociólogo es de tal envergadura, que lo hace uno de los grandes pensadores mundiales de esa disciplina. En América Latina, junto con el argentino Gino Germani y el brasileño Florestan Fernandes, integra el triunvirato de jefes o padres de la sociología latinoamericana.
La Democracia en México
Authors: Acosta Varela Nolberto
Published: February 2023

La Democracia en México (1965), es un estudio pionero, realizado desde la ciencia social que aborda uno de los temas menos favorecidos, no solamente en el país, sino en el conjunto del subcontinente americano. La democracia fue siempre un tema no prioritario para los regímenes políticos, las organizaciones corporativas, el entramado institucional y la sociedad civil, no obstante, él tuvo la intensión de forjar una línea investigativa en el ámbito teórico y la praxis de la democracia, condición fundamental para el desarrollo de las formas de gobierno y de sociedad.
La importancia de la investigación colegiada y con impacto social
Authors: Pineda Jaime Servando , Vázquez Reyes Óscar
Published: February 2023

La verdadera investigación debe hacerse con pasión y generar conocimientos útiles para toma de decisiones y políticas públicas, destaca.
Mis encuentros con Don Pablo González Casanova
Authors: Orozco Víctor
Published: February 2023

En ese firmamento intelectual brillaba la estrella de Pablo González Casanova, famoso ya por varios hechos asociados a su vida como intelectual. Era autor de varios libros decisivos en los estudios sociales, principalmente su imprescindible "La Democracia en México", publicado en 1965. En 1970 se le había nombrado rector de la UNAM, después de haber desempeñado altos cargos académico-administrativos, entre otros el de director de la FCPyS.
Geographic identity of the concept of «Greater Altai» and promising areas of cross-border cooperation in the region
Authors:   Altai State University, DUNETS Alexander , MAMENOV Sergey ,   Altai State University
Published: February 2023

Introduction. The Altai Mountains are a mountain system that is part of the sub latitudinal Altai-Sayan mountainous country. The mountains are the watershed between the basins of the Arctic Ocean and the drainleess region of Central Asia. This is the territory where the sources of the Irtysh and the Ob are located. Materials and research мethods. The article uses a regional approach to the study of a mountainous region. From the standpoint of the historical-geographical approach, the historical aspects of the formation of the transboundary essence of the Great Altai concept are revealed. Research results. The analysis of the origin of the understanding of the transboundary essence of Altai as a territory of cooperation is carried out. Expeditionary groups have been identified that have made a significant contribution to the understanding of the Great Altai. This made it possible to present the modern features of the economic, geographical and geopolitical position of the region. Discussion. A concept for the development of the region within the framework of the main areas of cooperation is proposed. The interests of Russia are indicated to promote the uniqueness of the territory and use its opportunities for tourism. Conclusion. The geographical position and natural resources make the Altai Mountains an important object in the development of cross-border cooperation. Since the 18th century scientists are actively exploring the territory for its effective use. The Great Altai has the prospect of becoming a trade and economic corridor between Russia, Mongolia and China. Resume. Since the beginning of the 2000s, forms of cross-border cooperation between the countries of the Greater Altai have appeared. The developed concept of the economic council within the framework of the ISS «Altai» will help to implement cooperation in various areas.
Characteristic and distribution of grain sizes and minerals in sediments in a part of the Vietnamese Gulf of Tonkin
Authors: Nhon Dang Hoai , Thao Nguyen Van , Thanh Tran Duc , Ve Nguyen Dac , Vuong Bui Van , Thuy Lai Thi Bich , Loan Bui Thi Thanh , Chien Hoang Thi , Nghi Duong Thanh
Published: February 2023

Grain sizes and minerals from Gulf of Tonkin sediments were evaluated from 30 surface samples and 50 samples in two cores, distribution of grain sizes and minerals to help understand sediment characteristics, origins, and environmental dynamics. There were five sediment types: Fine and very fine sands were found nearshore where land-sea interactions were stronger than offshore, whereas very coarse, coarse, and medium silts were found offshore, in small bays, river mouths with weak land-sea interactions, or near source sediment supplies. Minerals in sediment were identified as decreasing in the content of quartz, illite, kaolinite, chlorite, feldspar, goethite, halite, calcite, gibbsite, aragonite, and montmorillonite. Content of major minerals such as quartz, illite, kaolinite, and chlorite varied from nearshore to offshore; quartz was higher nearshore than offshore; illite, kaolinite, and chlorite nearshore were lower than offshore; calcite and aragonite were low nearshore and high in offshore; goethite was lower offshore and higher nearshore, while halite was high offshore and low nearshore. Surface sediments were divided into three groups based on sedimentary environment characteristics: group 1 was distributed nearshore with strong dynamics, group 2 in bays and nearshore with weak dynamics, and group 3 was distributed offshore with quiet dynamics. The origin of the sediments is weathering and erosion from the mainland and islands under the river and sea processes in the Gulf of Tonkin with quartz, illite, kaolinite, feldspar, chlorite and montmorillonite presenting in the sediment. Geochemical processes produced goethite, gibbsite, halite and pyrite in the sediments. Biological substances produced calcite and aragonite.
Frank-Read Mechanism in Nematic Liquid Crystals
Authors: Long Cheng , Deutsch Matthew , Angelo Joseph , Culbreath Christopher , Yokoyama Hiroshi , Selinger Jonathan , Selinger Robin
Published: February 2023

In a crystalline solid under mechanical stress, a Frank-Read source is a pinned dislocation segment that repeatedly bows and detaches, generating concentric dislocation loops. We demonstrate that in nematic liquid crystals, an analogous Frank-Read mechanism generates concentric disclination loops. Using experiment, simulation, and theory, we study a disclination segment pinned between surface defects on one substrate in a nematic cell. Under applied twist of the nematic director, the pinned segment bows and emits a new disclination loop which expands, leaving the original segment intact; loop emission repeats for each additional 180 degrees of applied twist. We present experimental micrographs showing loop expansion and snap-off, numerical simulations of loop emission under both quasistatic and dynamic loading, and theoretical analysis considering both free energy minimization and the balance of competing forces. Lastly, we discuss potential use of Frank-Read sources to modify microstructural evolution in both passive and active nematics.
In vitro –assessment of Remineralization and Microleakage of Tetra Calcium Phosphate Composite Versus Glass Ionomer Restorative Materials
Authors: Khalifa Fatma El-Zahraa F , Elsayed Manal A. , Elshiekh Manal Ahmed
Published: February 2023

Objectives: This study aimed to evaluate and compare the efficacy of composite releasing Ca and PO4 ions versus conventional glass Ionomer, resin-modified glass Ionomer and hybrid composite regarding remineralization capacity and Microleakage.
Methods: thirty-four caries-free premolars were used, and class v cavities were prepared on each tooth. These teeth were divided into four groups and restored with the following materials : (Resin-modified glass Ionomer RMGI, Glass Ionomer GI, Hybrid composite HC, Tetracalcium phosphate composite TTCP). Sixteen teeth were stored in demineralized solution for two days then examined by SEM. All treated teeth were stored in a glass bottle in artificial saliva of pH 7 at 37oC for periods 30 days then examined by SEM. Two specimens used as a baseline. 16 teeth were sectioned longitudinally in a buccolingual direction through the middle of restoration after immersed in 1% methylene blue solution for 24h, observation for marginal leakage was done under Stereomicroscope at 10X.
Results SEM micrographs of group glass-ionomer showed almost normal enamel surface with numerous mineral deposits. The resin-modified glass-ionomer showed enamel surface exhibits almost normal appearance and has minute mineral deposits. The hybrid composite showed enamel surface irregularities and slight separation between enamel and restoration and Tetracalcium phosphate TTCP showed almost normal enamel surface that occluded by numerous mineral deposits.
Conclusions: Tetracalcium phosphate composite and resin-modified glass ionomer, are highest marginal sealing than either hybrid composite and conventional glass-ionomers. Tetracalcium phosphate composite, are more effective at remineralization capacity than other groups.
YouTube as a source of information on ectopic pregnancy : a qualitative and quantitative analysis
Authors: BULLE Camille , LALLEMANT Marine , RIGORI Clara , RAMANAH Rajeev
Published: February 2023

Objective
The aim of this study was to assess the quality and reliability of YouTube videos on ectopic pregnancies for the public.
Method
We searched for the key terms “ectopic pregnancy”, “ectopic birth” and “extra uterine pregnancy” on YouTube. Each video that met the inclusion criteria was analyzed by two independent raters. Quantitative and qualitative metrics were recorded, and the videos were scored using the DISCERN instrument.
Results
A total of 37 videos met the inclusion criteria. The mean overall DISCERN score was 44.5 ± 15.6. Videos had significantly a higher DISCERN score if they contained explanations on anatomy (pvalue < 0.01), physiopathology (p-value < 0.01), diagnosis (p-value = < 0.01), treatments (p-value < 0.01), symptoms (p-value < 0.01), clear information (p-value < 0.01), animations (p-value < 0.01) and if it was a physician speaking (p-value < 0.01).
Conclusion
YouTube videos on ectopic pregnancy have been assessed to be only fairly reliable. We identified the five best ones using the validated DISCERN instrument. While ectopic pregnancy is not uncommon, YouTube videos should be improved to provide more accurate information for the public.
Manipulation of Shallow-Trap States in Halide Double Perovskite Enables Real-time Radiation Dosimetry
Authors: Wang Yumin , Chen Gaoyuan , Qin Haoming , Yang Liangwei , Zhu Zibin , Zhang Duo , Yang Yingguo , Qiu Menglin , Liu Ke , Chai Zhi , Yin Wan-Jian , Wang Yaxing , Wang Shuao
Published: February 2023

Storage phosphors displaying defect emission are indispensable in technologically advanced radiation dosimeters. The current dosimeter is limited to the passive detection mode, where ionizing radiation-induced deep-trap defects must be activated by external stimulations, such as ultraviolet light or heat. Herein, we designed a new type of shallow-trap storage phosphor by controlling the dopant amounts of Ag+ and Bi3+ in the host lattice of Cs2NaInCl6. A distinct phenomenon of X-ray-induced emission (XIE) is observed for the first time in an intrinsically nonemissive perovskite. The intensity of XIE exhibits a quantitative relationship with the accumulated dose, enabling a real-time radiation dosimeter. Thermoluminescence and in situ X-ray photoelectron spectroscopy verify that the emission originates from radiative recombination of electrons and holes associated with X-ray-induced traps. Theoretical calculations reveal the evolution process of Cl-Cl dimers serving as hole trap states. Analysis of temperature-dependent radioluminescence spectra provides evidence that the intrinsic electron-phonon interaction in 0.005Ag+@Cs2NaInCl6 is significantly reduced under X-ray irradiation. Moreover, 0.025Bi3+@Cs2NaInCl6 shows an elevated sensitivity to the accumulated dose with a broad response range from 0.08 Gy to 45.05 Gy. This work discloses defect manipulation in halide double perovskites, giving rise to distinct shallow-trap storage phosphors that bridge traditional deep-trap storage phosphors and scintillators and enabling a brand-new type of materials for real-time radiation dosimetry.
Effects of wheat bran replacement with Pomegranate Seed Pulp on rumen fermentation, gas production, Methanogen and Protozoa population of camel and goat rumen using competitive PCR technique: An in Vitro Study
Authors: Torbati Mohammad Bagher Montazer , Jaberi Sanaz , Ghiasi Seyed Ehsan
Published: February 2023

This study aimed to investigate the effect of PSP (Pomegranate Seed Pulp) on rumen fermentation, digestibility, and methanogens and protozoa population (by competitive PCR) of the camel and goat rumen fluid. Treatments included 0, 5 and 10% PSP replaced wheat bran. Rumen fluid was collected from 3 goats and 2 camels according to the similarity of sex, breed, origin and time and used for three gas production tests. DNA extraction was performed by RBB + c method, band intensities (target and competing DNA) were calculated by the ImageJ program and line gradients were plotted based on the number of copies and intensity. Diets had no significant effect on methanogen and protozoa population (P < 0.05), but Based on numerical counting, diet containing 5% PSP reduced the microbial population. Animal species affected microbial populations so that both populations in camels were less than goats (P < 0.05). The production of gas and volatile fatty acids was not affected by diets. These two parameters and NH3 concentration and methane production in goats were higher than camel (P < 0.05). The pH digested dry matter and microbial protein in camels were higher than in goats (P < 0.05). Therefore, the competitive PCR technique is an effective method for the enumeration of Rumen microbiota. Dietary supplementation with pomegranate seed pulp can modify the methanogen and protozoa population, reduce methane production and increase microbial protein will improve the animal's energy resources and feed protein. This supplementation can be considered as a strategy to achieve performance and environmental benefits.
Comparison of 0.0625%,0.075% and 0.1% ropivacaine on Epidural-Related Maternal Fever and inflammatory factors: a prospective and randomized control trial
Authors: Xiao Biru , Wang Zilu , Xiong Yicheng , Li Xinmiao , Yang Xiaodan , Li Juan , Zhang Hang , Wen Wen , Feng Sizhe , Chen Hongfei , Xiong Xiangqing
Published: February 2023

Backgroud: Women in labor who receive epidural analgesia are more likely to experience intrapartum fever, which is defined as Epidural-related maternal fever (ERMF). The mechanisms of ERMF remain incompletely understood. At present, there are no effective means to prevent epidural-associated fever. This study was to investigate the effects of different concentrations of ropivacaine on intrapartum fever and pyrogenic factors during epidural labor analgesia. Methods 123 full-term single first-term primiparas who were hospitalized for delivery and willing to receive patient-controlled epidural analgesia (PCEA) were selected as research objects. Analgesia was randomly provided with one of three groups: (Group A) 0.0625% ropivacaine with 1ug/ml fentanyl, (Group B) 0.075% ropivacaine with 1ug/ml fentanyl, (Group C) 0.1% ropivacaine with 1ug/ml fentanyl. The primary outcome was the tympanic temperature. The secondary outcomes included plasma inflammatory factor levels, VAS score, labor duration and neonatal Apgar score. Results At T2(T2 = four hours after analgesia), the average body temperature of Group C was higher than that of the other two groups (P < 0.05, Table 2), but there was no significant difference between Group A and Group B (P > 0.05, Table 2). At T3(T3 = eight hours after analgesia), the average temperature of Group C was higher than that of Group B and that of Group B was higher than that of Group A (P < 0.05, Table 2). At T2, plasma thermogenesis factors IL-6, TNF-α, PGE2 and RANTES in Group C were higher than those in Group A and Group B (P < 0.05), but there was no significant difference between Group A and group B (P > 0.05). At T3, the above inflammatory factors in group C were higher than those in group B (P < 0.05), and those in group B were higher than those in group A (P < 0.05). There were no significant differences in delivery time, VAS score and neonatal Apgar score among the three groups (P > 0.05). Conclusions This study suggests that lower concentration of ropivacaine results in lower tympanic temperature, which was associated with lower levels of inflammatory factors. Trial registration: This prospective and randomized control trial was registered at Chinese Clinical Trial Registry (https://www.chictr.org.cn/edit.aspx?pid=141149&htm=4, identification number: ChiCTR2100053761; principal investigator: Xiangqing Xiong; date of registration: 29/11/2021) before patient enrollment.
A nomogram for predicting prognosis in patients with acute respiratory distress syndrome (ARDS) and acute renal injury (AKI): A retrospective cohort study
Authors: Yu Xueshu , Zhang Xianwei , Xu Wen , Ruan Xiangyuan , Ye Yincai , Pan Jingye
Published: February 2023

Background Acute respiratory distress syndrome (ARDS) combined with acute kidney injury (AKI) remains a challenge for clinicians. Early identification of high-risk patients is essential to ensure proper management. However, the present literature does not provide such an instrument. The purpose of this study is to develop a fast and easy to manage instrument to predict the prognosis of patients with ARDS and AKI. Methods We extracted data from Medical Information Mart for Intensive Care-IV v2.0. Variable selection was based on LASSO regression. Then, we constructed a nomogram model and the performances of the model were evaluated with area under the curve (AUC), and decision curve analysis (DCA) respectively. Results We have developed a novel and practical nomogram that accurately predicted ARDS combined with AKI. The AUC of the novel model was better than that of SOFA and SPAS II (all P < .001). DCA showed that the nomogram model had a better net benefit than SOFA and SPAS II. Conclusions We had developed a novel scoring tool that accurately predicts the prognosis of ARDS combined with AKI and may help improve patient outcomes. This finding, however, needs to be confirmed by external validation as well as multi-centre prospective studies.
Impact of Altering the Method to Score During Small-sided Games on Internal and External Training Loads in Youth Soccer Players
Authors: Silva Marxno Ermesony Sabino da , Ribeiro Bruno Laerte Lopes , Ferreira Ayrton Bruno de Morais , Nakamura Fábio Yuzo , Oliveira Ricardo Santos , Mortatti Arnaldo Luis
Published: February 2023

INTRODUCTION: Diverse strategies to manipulate acute training load can be used in small-sided games (SSG). However, how different methods to score during SSG influence internal and external workloads in young athletes is still under debate.
OBJECTIVE: To compare external and internal training loads between SSGs played with different rules to score in young soccer players.
METHODS: In separated days, 13 young athletes (age: 14.7±0.4 years) performed three different SSGs models: ball possession (BP-SSG), score zone (SZ-SSG), and SSG with small-goals (SG-SSG). During the SSGs players worn accelerometers to obtain raw acceleration values which were later transformed in external training load (ETL) measured as PlayerLoad®. ~30-min following the SGGs internal training load (ITL) was obtained as the session-rating of perceived exertion (session-RPE).
RESULTS: The BP-SSG (369.05±66.6 a.u.) led to higher ETL compared to the SZ-SSG (326.22±50.6 a.u.), and to the SG-SSG (288.08±52.92 a.u.). Similarly, the BP-SSG (238.69±32.21 a.u.) also caused higher ITL compared to the SZ-SSG (208.57±32.17 a.u.), and to the SG-SSG (187, 38±30.4 a.u.).
CONCLUSION: In young soccer players, SSGs with the aim to maintain ball possession caused higher ITL and ETL compared to SSG with other methods to score. Coaches are encouraged to use SSG with the aim to maintain ball possession when designing high-intensity sessions, whereas for low-intensity sessions SSG with the small-goals zone can be used.
Cajanus cajan (L) Millsp. seed extract ameliorated scopolamine-induced amnesia through increase in antioxidant defense mechanisms and cholinergic neurotransmission
Authors: Olubodun-Obadun Taiwo Grace , Ishola ismail O , Akinwande Abisola Sekinat , Adeyemi Olufunmilayo Olaide
Published: February 2023

Decline in cholinergic function and oxidative/nitrosative stress play a central role in Alzheimer’s disease (AD). Our quantitative preliminary study revealed the presence of several neuroprotective flavonoids in Cajanus cajan seed extract. Hence, this study was designed to investigate the protective action of Cajanus cajan ethanol seed extract (CC) on learning and memory functions using scopolamine mouse model of amnesia. Adult mice were first pretreated with CC (50, 100, or 200mg/kg, p.o) or vehicle (10ml/kg, p.o) for 16 days. Scopolamine an anti-muscarinic agent (1mg/kg) was given an hour after CC pretreatment from days 3 to 16. The mice were subjected to behavioural tests (open field test (OFT), Y-maze test (YMT) or Morris water maze task (MWM). Animals were euthanized on day 16 and biochemical analysis was carried on the brain tissue to assay for biomarkers of oxidative stress and cholinergic system. Molecular docking analysis was also done to investigate the possible mechanism(s) through which CC exerts its anti-amnesic action. The results showed that the pre-administration of CC ameliorated working memory and learning deficits caused by scopolamine in YMT and MWM tests, respectively. CC improved cholinergic function via attenuation of scopolamine-induced increase in acetylcholinesterase activity in the hippocampus. Furthermore, CC attenuated scopolamine-induced oxidative stress and increased nitrite generation in the hippocampus evidenced in significant increase in glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) activities with a marked decrease in malondialdehyde (MDA) levels. Phytochemicals obtained from CC displayed significant interaction at the M1 muscarinic acetylcholine receptor, alpha-7 nicotinic acetylcholine receptor and amyloid beta peptide binding pockets which suggests the involvement of these target proteins in the activity of CC. Findings obtained from this study showed that CC improved working memory and learning through enhancement of cholinergic systems and reduction in amyloidogenesis.
A platform for deep learning on (meta)genomic sequences
Authors: Münch Philipp , Mreches René , To Xiao-Yin , Gündüz Hüseyin Anil , Moosbauer Julia , Klawitter Sandra , Deng Zhi-Luo , Robertson Gary , Rezaei Mina , Asgari Ehsaneddin , Franzosa Eric , Huttenhower Curtis , Bischl Bernd , McHardy Alice , Binder Martin
Published: February 2023

We describe deepG, a platform for the generation, interpretation, and application of deep learning models for sequence labeling, classification, and regression based on nucleotide sequences. Unlike other bioinformatic deep learning platforms that focus on training on the human genome, deepG can handle sets of (meta)genomes via a range of data augmentation strategies, allowing for the training of highly accurate predictive models on reads, contigs, genomes, or metagenomes.
Cortical thickness and Subcortical volume changes differ between Parkinson disease subtypes
Authors: Huang Mingming , Yu Hui , Guo Kunle , Yin Jianhong , Lei Pinggui , Gao Bo
Published: February 2023

BACKGROUND: To explore the different patterns of cortical thickness and subcortical volume changes between Parkinson disease (PD) subtypes by structural magnetic resonance imaging (MRI).METHODS:We enrolled 48 clinically confirmed PD patients, including 23 tremor dominant (TD) and 25 postural instability gait dominant (PIGD) subtypes, and 32 matched healthy control (HC) volunteers were also collected, all subjects underwent 3.0 Tesla high-resolution structural MRI scanning. Cortical thickness and subcortical volumetric analysis were estimated using an automated Computational Anatomy Toolbox (CAT12) toolbox.Results:Compared with the HC group, PIGD patients had significantly thinning cortical thickness in multiple brain regions, such as bilateral inferiorparietal, paracentral, precuneus, superiorfrontal, caudalmiddlefrontal, posteriocingulate, parahippacampal, lateraloccipital and right superiortemporal, supramarginal and parsorbitals. TD patients had slightly thinning focal cortical thickness in bilateral posteriocingulate, left inferioparietal and right precuneus. PIGD patients had thinner cortical thickness in left caudalmiddlefrontal, parahippacampal and right isthmuscingulate and lateraloccipital than TD patients. In addition, subcortical volume atrophy was identified in the bilateral hippocampus and bilateral amygdala of the patients with PIGD, only right hippocampus changes were found in the TD group. Moreover, the largest area under the ROC curve of hippocampus and atrophy ratio, cortical thickness in region of interest (ROI) and combination of hippocampus ratio, atrophy ratio and cortical thickness in ROIs which for distinguish PIGD from TD were 0.733, 0.912 and 0.999 respectively.Conclusions:Morphometric abnormalities were greater in the PIGD than that in the TD subtype, the disparate patterns of cortical and subcortical degeneration had a potential possibility to distinguish the PD subtypes by MRI perspective in clinical practice.
Unfolding the hydrogen gas sensing mechanism across 2D Pnictogen/Graphene heterostructure sensors
Authors: Kumar Neeraj , Jasani Jaykumar , Sonvane Yogesh , Korvink Jan , Sharma Ashutosh , Sharma Bharat
Published: February 2023

Hydrogen as a source of clean and future alternative to fossil fuels demands a class of powerful gas sensor technologies. To this end, we have developed unique bi-stacked heterogeneous layers based on 2D Pnictogens and graphene sheets via photolithography and pattern transfer methods. The nanoengineered heterostructure morphology consists of truncated/hexagonal antimonene flakes dispersed on graphene sheets. Amongst the Pnictogen class, the hybrid antimonene-graphenes (Sb/G) demonstrated excellent sensing behavior characterized by a large gas response to H2 (~4-fold improvement), high selectivity, fast response/recovery times (>3 fold reduction), and ultra-low limit of detection (LOD: 0.05 ppm) in comparison to pristine sensors. The microstructural and density functional theory (DFT) calculations demonstrated a Bader charge transfer mechanism from Sb/G heterojunction to the H2 gas, which modulated the Schottky barrier and improved gas response. The outstanding performance of the Sb/G sensor places it amongst the highly selective and fast hydrogen sensors based on the Pnictogen-graphene family.
Invasion trends of aquatic Ludwigia hexapetala and L. peploides subsp montevidensis (Onagraceae) in Italy based on herbarium records and global datasets
Authors: Gori Benedetta , Pezzi Giovanna , Brundu Giuseppe , Ceschin Simona , Palella Emanuele , Alessandrini Alessandro , Amadei Lucia , Andreatta Sebastiano , Ardenghi Nicola Maria Giuseppe , Armiraglio Stefano , Bagella Simonetta , Bolpagni Rossano , Bonini Ilaria , Bouvet Daniela , Brancaleoni Lisa , Buccheri Massimo , Buffa Gabriella , Chiarucci Alessandro , Cogoni Annalena , Domina Gianniantonio , Guarino Riccardo , Forte Luigi , Gubellini Leonardo , Guglielmone Laura , Hofmann Nicole , Iberite Mauro , Lastrucci Lorenzo , Lucchese Fernando , Marcucci Rossella , Mei Giacomo , Mossetti Umberto , Nascimbene Juri , Passalacqua Nicodemo Giuseppe , Peccenini Simonetta , Prosser Filippo , Repetto Giovanni , Rinaldi Gabriele , Romani Enrico , Rosati Leonardo , Santangelo Annalisa , Scoppola Anna , Spampinato Giovanni , Stinca Adriano , Tavano Maria , Caruso Fulvio Tomsich , Vangelisti Roberta , Venanzoni Roberto , Vidali Marisa , Vilhalm Thomas , Zonca Francesco , Buldrini Fabrizio , Lambertini Carla
Published: February 2023

Identifying areas susceptible to invasion by an alien species is a strategy of prevention. We used national herbaria and global databases to assess the invasion trends of the two aquatic invasive species Ludwigia hexapetala and Ludwigia peploidessubsp. montevidensis in Italy. We defined the invasion status with invasions curves and predicted potentially suitable areas with Species Distribution Models based on WorldClim variables and the human footprint index. Low seasonal variation in temperature and precipitation, temperature ≥ 20 °C in the warmest, driest and wettest periods of the year and precipitation in the coldest period are the bioclimatic factors that most account for the potential distribution of the two species. The human footprint has lower relative importance than bioclimatic variables. All Italian peninsula appears as a suitable bioclimatic environment for the invasion of the two Ludwigia species, except the Alps and the highest peaks in the Apennine. Based on the current distribution of the species in Italy and the mostly densely invaded areas globally, the agricultural land surrounding the current invaded areas and along the Italian coasts is the most vulnerable to the invasion. Considering the trend of the invasion curves, which have been sharply rising for the latest decades, there are reasons to expect that the alien Ludwigia species will continue their expansion, if no timely and effective actions are taken. Informative campaigns, accurate monitoring and prompt management are fundamental preventive tools in areas predicted as vulnerable to invasion by this study.