bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of an OSA Risk Screening Smartphone App in a General, Non-Symptomatic Population Sample (ESOSA)
Authors: Sommer J. Ulrich , Lindner Lisa , Kent David T. , Heiser Clemens
Published: August 2024

Background: Obstructive Sleep apnea (OSA) is a prevalent sleep disorder, risk factor for cardiovascular disease and imposes a substantial global socioeconomic and health burden. OSA is insufficiently diagnosed as it often presents with unspecific or no symptoms. This study compares the effectiveness of a smartphone-based screening method to polysomnography (PSG) in a general, non-symptomatic population sample. Methods: Adult subjects were recruited from the general population. Subjects reporting OSA-related symptoms suggesting an increased OSA risk were excluded. Included subjects underwent Type-II PSG and a parallel breathing sound analysis using the Snorefox M smartphone app. The PSG scores were compared with the results of the Snorefox M app for its ability to detect moderate to severe OSA (AHI ≥ 15). Results: 150 subjects were included. All subjects completed the diagnostic night, no adverse events occurred. A valid analysis result was obtained for 142 subjects. A total of 24% of subjects had moderate to severe OSA based on the PSG results. The Snorefox M software app showed a sensitivity of 0.91 (0.76, 0.98), specificity of 0.83, PPV of 0.63 (0.48, 0.77), and NPV of 0.97 (0.91, 0.99) to detect AHI ≥ 15 compared with the reference PSG (95% CI). Conclusions: This study compares for the first time, the performance of an app-based OSA screening tool with PSG in a non-symptomatic population sample. Easily accessible screening tools can play a role in complementing existing diagnostic possibilities, helping to increase the diagnosis rate, with a positive effect on cardiovascular health in a relevant population share.
Blue and Yellow Laccases from Alternaria sp. Strain HU: Characterization and Immobilization on Magnetic Nanoparticles
Authors: Radveikienė Ingrida , Vidžiūnaitė Regina , Meškys Rolandas , Časaitė Vida
Published: August 2024

Laccases are important and valuable enzymes with a great potential for biotechnological applications. In this study, two novel laccases, LacHU1 and LacHU2, from Alternaria sp. HU have been purified and characterized. The molecular mass of each isoenzyme was ~66 kDa. LacHU1 laccases was yellow and had no typical blue oxidase spectra and LacHU2 had a blue color and characteristic absorption spectra. The catalytic efficiency of LacHU1 for most substrates was higher than that of LacHU2 laccase. Both isoenzymes effectively oxidize flavonoids. Alternaria sp. laccases were successfully immobilized on magnetic nanoparticles. The thermostability of immobilized laccases increased and optimal pH shifted to more alkaline compared to the free laccases. Potential applications of laccases from Alternaria sp. HU are in the oxidation of flavonoids in cotton or in water treatment processes.
How Does the Habitat Environment Affect the Life Satisfaction of County Residents? An IPA-Kano Model Analysis Based on Western China
Authors: Hou Yuan , Huang Yaofu , Yin Jiangbin , Xu Zhipeng
Published: August 2024

Coordinating the construction of villages and towns with the county as the basic unit and promoting the optimal allocation of infrastructure and public utilities within the county is an important measure to improve the rural habitat and enhance the well-being of residents. Using the field survey data from western China and the IPA-Kano model method, this study reveals the importance of the impact of habitat environment on life satisfaction in county seat, town and village communities, and identifies the priorities for improvement and enhancement in light of their actual performance. The empirical analysis found that the three types of communities have some differences in the classification of basic factors, key performance factors and excitement factors, and their priorities for improvement are also different. Overall, the improvement priorities of town and village communities are relatively similar, and the differences between the two types of communities and county seat’s communities are obvious. Differentiated improvement measures should be adopted for different types of communities in order to effectively improve the well-being of residents and achieve rational allocation of public resources.
The Spatio-Temporal Development and Influencing Factors of Urban Residential Land Prices in Hebei Province, China
Authors: Wang Yutong , Yang Jianyu
Published: August 2024

Against the backdrop of rapid urbanization and coordinated development in the Beijing–Tianjin–Hebei region of China, urban residential land prices in Hebei Province have experienced significant increases, exacerbating housing pressures on residents. This study aims to elucidate the spatio-temporal evolution characteristics of urban residential land prices, identify the key influencing factors in Hebei Province of China, and offer insights on macro-control of the land market, optimization of the land supply structure, and guidance on the sustainable development of land and real estate markets in the region. Utilizing land price monitoring data from 11 prefecture-level cities in Hebei Province spanning the past five years, this research employs quantitative methods, such as the Theil index, the standard deviation ellipse, and the geographic detector model, to analyze the spatio-temporal dynamics and factors shaping urban residential land prices. The results show that: (1) Urban residential land prices in Hebei Province exhibited an overall upward trend from 2018 to 2022, characterized by pronounced spatial variations, with higher prices predominantly concentrated in the cities along the Shijiazhuang–Baoding–Langfang–Tangshan corridor; (2) The distribution pattern of urban residential land prices generally mirrors that of GDP, indicating a consistent movement of price centers with urban land price escalation; (3) Urban land prices are influenced by multiple factors in combination, where the interactions among these factors outweigh the impact of any single factor. Specifically, the proportion of GDP attributed to the tertiary industry and location conditions emerge as pivotal factors affecting urban residential land prices in Hebei Province. Given these significant spatial disparities, addressing the industrial structure and optimizing urban land resource allocation are critically imperative.
Geohazard Prevention Framework: Introducing a Cumulative Index in the Context of Management and Protection of Cultural and Natural Heritage Areas
Authors: Papakonstantinou George Faidon D. , Papadopoulou Maria P.
Published: August 2024

Geohazards pose an essential role to the preservation of cultural and natural heritage areas, given their valuable significance in terms of scenic, natural, and cultural characteristics, forming unique landscapes that require proactive action to achieve sustainable environmental management. To address these challenges, a methodological framework focusing on geohazard prevention, emphasizing the importance of a pre-management stage that enables stakeholders to prioritize resources and implement landscape planning strategies, is proposed in this paper. In this framework, an integrated set of geospatial, geological, meteorological, and other relevant environmental factors to quantify cumulative geohazard zones in heritage areas is utilized. Implementing advanced tools such as geographic information systems (GISs), remote sensing techniques, and geospatial data analysis, a clustering and characterization of various geohazards is obtained, providing a comprehensive understanding of their cumulative impacts. The introduction of a cumulative geohazard index is proposed in this paper to better understand and then assess the impacts of environmental-driven geohazards that may affect cultural and natural heritage areas to be embedded into the impact assessment process. The validation of the proposed geohazard framework and index is performed in the Parrhasian Heritage Park in Peloponnese, Greece. The outcomes of the analysis highlight the need to mitigate geohazard impacts through early and in situ targeted actions to facilitate the decision-making process and contribute to the protection of evolving landscapes with cultural and natural elements for future generations.
Preparation of Paper-Based Fluorescent Sensors and Their Application for the Detection of Cu2+ in Water
Authors: Ma Yue , Li Hui , Li Yufeng , Wei Dong
Published: August 2024

Excessive copper (Cu2+) causes adverse effects on human health and the ecological environment. Traditional methods for detecting Cu2+ have drawbacks such as high detection costs, complex operating conditions, and being time consuming. Therefore, there is an urgent need to develop simple detection methods to better meet specific health and environment quality needs. In this work, a paper-based fluorescence sensor was prepared (herein referred to as the as-prepared method) by immersing filter paper in aqueous polyethyleneimine (PEI) solution, and its potential use in Cu2+ detection was investigated. The results showed that the as-prepared paper samples, with fluorescence properties obtained by aggregation-induced luminescence of PEI, have selective recognition of Cu2+ based on the internal filtration effect, and the lowest detection limit is 0.03 μM. In addition, the relative error of this method is in the range of 1.80~2.23%, which is relatively comparable to the national standard method (0.63~630 μM), demonstrating high accuracy. Therefore, paper-based sensors with a simple preparation method have potential applications in the detection of Cu2+ in water.
Numerical Study of Solid–Gas Two-Phase Flow and Erosion Distribution in Glass Fiber-Reinforced Polymer Ball Valves
Authors: Chen Qi , Xia Yazhong , Yu Jiuyang , Dai Yaonan , Peng Kang , Zhang Tianyi , Liu Bowen
Published: August 2024

The use of glass fiber-reinforced polymer (GFRP) composites in fluid transport systems can effectively reduce corrosion damage caused by corrosive media. However, collisions between solid particles and the surfaces of ball valve flow passages can cause erosion damage and lead to safety issues. The two-phase flow and erosion characteristics of ball valves manufactured from resin-based fiber-reinforced composite materials were studied under different openings and particle sizes using the CFD-DPM method. The results indicate that both smaller and larger relative openings are prone to erosion damage at the thin edges of the valve ball. As the relative opening increases, the average erosion amount in the flow passage first increases and then decreases. The maximum average erosion amount is 0.0051 kg/m2·s when the relative opening is Cv = 40. At Cv = 40, erosion damage in the flow channel mainly occurs at the bottom of the inlet flow channel and the valve seat position. With increasing particle size, both the average and maximum erosion amounts in the flow channel increase. Larger particle sizes in the inlet flow channel significantly raise the erosion rate nearby, while at other locations, larger particle sizes mainly increase the erosion rate in the same area. During the use of GFRP valves, it is important to avoid introducing large-sized particles into the medium. Keeping the valve’s relative opening greater than 40 and using more erosion-resistant materials for the valve seat can effectively reduce the erosion of the composite ball valve and extend its service life.
Testing Coefficient Randomness in Multivariate Random Coefficient Autoregressive Models Based on Locally Most Powerful Test
Authors: Bi Li , Wang Deqi , Cheng Libo , Qi Dequan
Published: August 2024

The multivariate random coefficient autoregression (RCAR) process is widely used in time series modeling applications. Random autoregressive coefficients are usually assumed to be independent and identically distributed sequences of random variables. This paper investigates the issue of coefficient constancy testing in a class of static multivariate first-order random coefficient autoregressive models. We construct a new test statistic based on the locally most powerful-type test and derive its limiting distribution under the null hypothesis. The simulation compares the empirical sizes and powers of the LMP test and the empirical likelihood test, demonstrating that the LMP test outperforms the EL test in accuracy by 10.2%, 10.1%, and 30.9% under conditions of normal, Beta-distributed, and contaminated errors, respectively. We provide two sets of real data to illustrate the practical effectiveness of the LMP test.
Existence and Nonexistence Results for a Fourth-Order Boundary Value Problem with Sign-Changing Green’s Function
Authors: Dimitrov Nikolay D. , Jonnalagadda Jagan Mohan
Published: August 2024

In this paper, we consider a fourth-order three-point boundary value problem. Despite the fact that the corresponding Green’s function changes its sign on the square of its definition, we obtain the existence of at least one positive and decreasing solution under some suitable conditions. The results are based on the classical Krasosel’skii’s fixed point theorem in cones. Then, we impose some sufficient conditions that allow us to deduce nonexistence results. In the end, some examples are given in order to illustrate our main results.
Content Determination and Chemical Clustering Analysis of Tanshinone and Salvianolic Acid in Salvia spp.
Authors: Wang Feiyan , Bao Yufeng , Yang Furui , Yuan Lu , Han Xinchun , Huang Yanbo , Wei Yukun , Zhang Lei , Yang Zongqi , Yang Dongfeng
Published: August 2024

Salvia miltiorrhiza is one of the famous traditional Chinese medicines for treating cardiovascular and cerebrovascular diseases. Tanshinone and phenolic acids are the main active compounds of Salvia miltiorrhiza, whereas the distribution patterns of the two kinds of components are still unclear among Salvia spp. In this work, high-performance liquid chromatography was applied to analyze the distribution patterns of major components in the roots and leaves of 58 Salvia spp. The results showed that the distribution patterns of tanshinone and phenolic acids in Salvia spp. varied significantly. Phenolic acid components such as rosmarinus acid, caffeic acid, and danshensu are widely distributed in the roots and leaves, and phenolic acids in the leaves of Salvia spp. are generally higher than that in roots. Tanshinones are mainly detected in the roots of Salvia przewalskii, Salvia trijuga, Salvia castanea, and Salvia yunnanensis. The content of major components of the different species varied significantly. The content of phenolic acids in most Salvia spp. generally followed the pattern of salvianolic acid B > rosmarinic acid > danshensu > caffeic acid both in the roots and leaves. Tanshinone IIA and cryptotanshinone were the main lipophilic components of Salvia spp. distributed in southwest China. A correlation between the distribution pattern of tanshinone and the genetic relationship of species was indicated in the work. This research systematically reveals the distribution patterns of tanshinone and phenolic acids in Salvia spp., providing a theoretical basis for the development and utilization of medicinal resources of Salvia.
The Drug Susceptibility of Non-Tuberculous Mycobacteria (NTM) in a Referral Hospital in Rome from 2018 to 2023
Authors: Mazzarelli Antonio , Nisii Carla , Cannas Angela , Vulcano Antonella , Bartolini Barbara , Turchi Federica , Butera Ornella , Rossi Alberto , De Giuli Chiara , Massimino Chiara , Stellitano Chiara , Antonelli Valentina , Petriccione Ivano , Girardi Enrico , Gualano Gina , Palmieri Fabrizio , Fontana Carla
Published: August 2024

Background: The treatment of non-tuberculous mycobacterial (NTM) infections is challenging because of the difficulty in obtaining phenotypic (pDST) and/or molecular (mDST) drug susceptibility testing and the need of a multi-drug regimen. Objectives: The objective was to describe the in vitro susceptibility patterns of various NTM species through an analysis of susceptibility results obtained on isolates collected between 2018 and 2023. Methods: Species identification and mutations in rrs or rrl genes (mDST) were identified by a line probe assay, while the pDST was performed by broth microdilution and interpreted according to CLSI criteria. Results: We analysed 337 isolates of NTM belonging to 15 species/subspecies. The Mycobacterium avium complex (MAC) was the most common (62%); other species identified included M. gordonae (11%), M. kansasii (5%), the M. abscessus complex (8%), M. chelonae (6%), and M. fortuitum (2%). The results of pDST (claritromycin and amikacin) and mDST (rrl and rrs genes) on 66 NTM strains showed that while wild-type rrl and rrs occurred in 86.3% and 94% strains, respectively, the pDST showed 88% sensitivity for clarithromycin and 57.5% for amikacin. The main incongruity was observed for macrolides. Conclusions: Most NTM are likely to be susceptible to macrolides and aminoglycosides. The molecular identification of resistant genotypes is accurate and strongly recommended for optimal patient management.
Impact of Intercropping Five Medicinal Plants on Soil Nutrients, Enzyme Activity, and Microbial Community Structure in Camellia oleifera Plantations
Authors: Bajiu Azuo , Gao Kai , Zeng Guangyu , He Yuanhao
Published: August 2024

Intercropping medicinal plants plays an important role in agroforestry that can improve the physical, chemical, and biological fertility of soil. However, the influence of intercropping medicinal plants on the Camellia oleifera soil properties and bacterial communities remains elusive. In this study, five intercropping treatment groups were set as follows: Curcuma zedoaria/C. oleifera (EZ), Curcuma longa/C. oleifera (JH), Clinacanthus nutans/C. oleifera (YDC), Fructus Galangae/C. oleifera (HDK), and Ficus simplicissima/C. oleifera (WZMT). The soil chemical properties, enzyme activities, and bacterial communities were measured and analyzed to evaluate the effects of different intercropping systems. The results indicated that, compared to the C. oleifera monoculture group, YDC and EZ showed noticeable impacts on the soil chemical properties with a significant increase in total nitrogen (TN), nitrate nitrogen (NN), available nitrogen (AN), available phosphorus (AP), and available potassium (AK). Among them, the content of TN and AK in the rhizosphere soil of Camellia oleifera in the YDC intercropping system was the highest, which was 7.82 g/kg and 21.94 mg/kg higher than CK. Similarly, in the EZ intercropping system, the content of NN and OM in the rhizosphere soil of Camellia oleifera was the highest, which was higher than that of CK at 722.33 mg/kg and 2.36 g/kg, respectively. Curcuma longa/C. oleifera (JH) and Clinacanthus nutans/C. oleifera (YDC) had the most effect on soil enzyme activities. Furthermore, YDC extensively increased the activities of hydrogen peroxide and acid phosphatase enzymes; the increase was 2.27 mg/g and 3.21 mg/g, respectively. While JH obviously increased the urease activity, the diversity of bacterial populations in the rhizosphere soil of the intercropping plants decreased, especially the Shannon index of YDC and HDK. Compared with the monoculture group, the bacterial community abundance and structure of JH and YDC were quite different. The relative abundance of Actinobacteriota and Firmicutes was increased in YDC, and that of Acidobacteriota and Myxococcota was increased in JH. According to the redundancy analysis (RDA), pH, total potassium, and soil catalase activity were identified as the main factors influencing the microbial community structure of the intercropping systems. In conclusion, intercropping with JH and YDC increased the relative abundance of the dominant bacterial communities, improved the microbial community structure, and enhanced the soil nutrients and enzyme activities. Therefore, in the future, these two medicinal plants can be used for intercropping with C. oleifera.
QTc Interval Prolongation as an Adverse Event of Azole Antifungal Drugs: Case Report and Literature Review
Authors: Kitaya Shiori , Nakano Makoto , Katori Yukio , Yasuda Satoshi , Kanamori Hajime
Published: August 2024

QTc prolongation and torsade de pointes (TdP) are significant adverse events linked to azole antifungals. Reports on QTc interval prolongation caused by these agents are limited. In this study, we report a case of a 77-year-old male with cardiovascular disease who experienced QTc prolongation and subsequent TdP while being treated with fluconazole for Candida albicans-induced knee arthritis. Additionally, a literature review was conducted on cases where QTc prolongation and TdP were triggered as adverse events of azole antifungal drugs. The case study detailed the patient’s experience, whereas the literature review analyzed cases from May 1997 to February 2023, focusing on patient demographics, underlying diseases, antifungal regimens, concurrent medications, QTc changes, and outcomes. The review identified 16 cases, mainly in younger individuals (median age of 29) and women (75%). Fluconazole (63%) and voriconazole (37%) were the most common agents. Concurrent medications were present in 75% of cases, and TdP occurred in 81%. Management typically involved discontinuing or switching antifungals and correcting electrolytes, with all patients surviving. Risk assessment and concurrent medication review are essential before starting azole therapy. High-risk patients require careful electrocardiogram monitoring to prevent arrhythmias. Remote monitoring may enhance safety for patients with implanted devices. Further studies are needed to understand risk factors and management strategies.
Mixed-Mode Adsorption of l-Tryptophan on D301 Resin through Hydrophobic Interaction/Ion Exchange/Ion Exclusion: Equilibrium and Kinetics Study
Authors: Wang Shengping , Jiao Pengfei , Zhang Zhengtian , Niu Qiuhong
Published: August 2024

The adsorption of l-tryptophan (l-Trp) was studied based on the hydrophobic interaction/ion exchange/ion exclusion mixed-mode adsorption resin D301. Firstly, the interaction mode between l-Trp and resin was analyzed by studying the influence of pH variation on the adsorption capability and the dissociation state of l-Trp. Secondly, the adsorption mechanism was illuminated by studying the adsorption equilibrium and kinetic behaviors. The adsorption equilibrium and a kinetics model were constructed. The augmentation of pH gradually elicited an enhancement in the adsorption capacity of l-Trp. l-Trp existing in varied dissociation states could be adsorbed by the resin, and the interaction mode relied upon the pH of the solution. An integrated adsorption equilibrium model with the coadsorption of different dissociation states of l-Trp was developed and could predict the adsorption isotherms at various pH levels satisfactorily. Both external mass transfer and intra-particle diffusion collectively imposed constraints on the mass transfer process of l-Trp onto the resin. An improved liquid film linear driving force model (ILM) was constructed, and the model provided a satisfactory fit for the adsorption kinetics curves of l-Trp at various pH levels. l-Trp molecules had a high mass transfer rate at a relatively low solution pH.
Constituents from Dolichos lablab L. Flowers and Their Anti-Inflammatory Effects via Inhibition of IL-1β Release
Authors: Shi Zhongwei , Li Huimin , Cheng Jiaming , Zhang Wei , Ruan Jingya , Zhang Qianqian , Dang Zhunan , Zhang Yi , Wang Tao
Published: August 2024

The occurrence of inflammation is closely related to the activation of the NLRP3 inflammasome. IL-1β produced during the activation of the NLRP3 inflammasome has strong pro-inflammatory activity and can also promote the release of inflammatory factors by other immune cells, exacerbating inflammatory damage to tissues. Utilizing IL-1β as the detection index to find small-molecule inhibitors targeting NLRP3 from natural products will benefit the search for drugs for inflammation-related diseases. During the exploration of anti-inflammatory active components derived from the flowers of Dolichos lablab L., an ingredient in traditional Chinese medicine with dual applications in both medicinal treatment and dietary consumption, fourteen compounds (1–14), including seven previously unreported ones, named flosdolilabnitrogenousols A–D (1–4) and flosdolilabsaponins A–C (5–7), were found. Their structures were established through extensive NMR spectra determination, HR-ESI-MS analysis, ECD calculations, and chemical reactions. Flosdolilabsaponin A (5) stands out as an exceptionally rare tetracyclic lactone oleane-type saponin. Additionally, the inhibitory activity on IL-1β release of all compounds, without cytotoxicity, was evaluated using BMDMs stimulated with LPS/Nigericin. An Elisa assay revealed that compounds 1, 8, 9, and 11–14 exhibited significant inhibition of IL-1β release at a concentration of 30 μM. Structure–activity relationships were also discussed. This study indicates that D. lablab flowers possess anti-inflammatory activity, which might exert its effect by suppressing the activation of the NLRP3 inflammasome.
Aqueous Synthesis of Au10Pt1 Nanorods Decorated with MnO2 Nanosheets for the Enhanced Electrocatalytic Oxidation of Methanol
Authors: Li Ting , Liu Yidan , Huang Yibin , Yu Zhong , Huang Lei
Published: August 2024

Developing novel catalysts with high activity and high stability for the methanol oxidation reaction (MOR) is of great importance for the ever-broader applications of methanol fuel cells. Herein, we present a facile technique for synthesizing Au10Pt1@MnO2 catalysts using a wet chemical method and investigate their catalytic performance for the MOR. Notably, the Au10Pt1@MnO2-M composite demonstrated a significantly high peak mass activity of 15.52 A mg(Pt)−1, which is 35.3, 57.5, and 21.9 times greater than those of the Pt/C (0.44 A mg(Pt)−1), Pd/C (0.27 A mg(Pt)−1), and Au10Pt1 (0.71 A mg(Pt)−1) catalysts, respectively. Comparative analysis with commercial Pt/C and Pd/C catalysts, as well as Au10Pt1 HSNRs, revealed that the Au10Pt1@MnO2-M composite exhibited the lowest initial potential, the highest peak current density, and superior CO anti-poisoning capability. The results demonstrate that the introduction of MnO2 nanosheets, with excellent oxidation capability, not only significantly increases the reactive sites, but also promotes the reaction kinetics of the catalyst. Furthermore, the high surface area of the MnO2 nanosheets facilitates charge transfer and induces modifications in the electronic structure of the composite. This research provides a straightforward and effective strategy for the design of efficient electrocatalytic nanostructures for MOR applications.
Identification of Fatty Acids, Amides and Cinnamic Acid Derivatives in Supercritical-CO2 Extracts of Cinnamomum tamala Leaves Using UPLC-Q-TOF-MSE Combined with Chemometrics
Authors: Lohani Hema , Kumar Arvind , Bidarakundi Vinod , Agrawal Lalit , Haider Syed Zafar , Chauhan Nirpendra Kumar
Published: August 2024

Cinnamomum tamala leaf (CTL), also known as Indian bay leaf, is used all over the world for seasoning, flavoring, and medicinal purposes. These characteristics could be explained by the presence of several essential bioactive substances and lipid derivatives. In this work, rapid screening and identification of the chemical compounds in supercritical (SC)-CO2 extracts of CTL by use of UPLC-Q-TOF-MSE with a multivariate statistical analysis approach was established in both negative and positive mode. A total of 166 metabolites, including 66 monocarboxylic fatty acids, 52 dicarboxylic fatty acids, 27 fatty acid amides, and 21 cinnamic acid derivatives, were tentatively identified based on accurate mass and the mass spectrometric fragmentation pattern, out of which 142 compounds were common in all SC-CO2 extracts of CTL. Further, PCA and cluster hierarchical analysis clearly discriminated the chemical profile of analyzed extracts and allowed the selection of SC-CO2 extract rich in fatty acids, fatty acid amides, and other bioactive constituents. The result showed that the higher number of compounds was detected in CTL4 (300 bar/55 °C) extract than the other CTL extracts. The mono- and di-carboxylic fatty acids, fatty acid amides, and cinnamic acid derivatives were identified in CTL for the first time. UPLC-Q-TOF-MSE combined with chemometric analysis is a powerful method to rapidly screen the metabolite profiling to justify the quality of CTL as a flavoring agent and in functional foods.
Advancing Silver Bismuth Sulfide Quantum Dots for Practical Solar Cell Applications
Authors: Mawaddah Fidya Azahro Nur , Bisri Satria Zulkarnaen
Published: August 2024

Colloidal quantum dots (CQDs) show unique properties that distinguish them from their bulk form, the so-called quantum confinement effects. This feature manifests in tunable size-dependent band gaps and discrete energy levels, resulting in distinct optical and electronic properties. The investigation direction of colloidal quantum dots (CQDs) materials has started switching from high-performing materials based on Pb and Cd, which raise concerns regarding their toxicity, to more environmentally friendly compounds, such as AgBiS2. After the first breakthrough in solar cell application in 2016, the development of AgBiS2 QDs has been relatively slow, and many of the fundamental physical and chemical properties of this material are still unknown. Investigating the growth of AgBiS2 QDs is essential to understanding the fundamental properties that can improve this material’s performance. This review comprehensively summarizes the synthesis strategies, ligand choice, and solar cell fabrication of AgBiS2 QDs. The development of PbS QDs is also highlighted as the foundation for improving the quality and performance of AgBiS2 QD. Furthermore, we prospectively discuss the future direction of AgBiS2 QD and its use for solar cell applications.
6′-Sialyllactose Enhances Exercise Performance via Increased Muscle Mass and Strength
Authors: Park Eun-Jung , Kim Li-La , Lee Jie-Oh , Lee Hay-Young , Kim Yong-An , Go Hi-Roe
Published: August 2024

Sialyllactose (SL) is a functional human milk oligosaccharide essential for immune support, brain development, intestinal maturation, and antiviral defense. However, despite its established health benefits, the effect of SL on exercise performance and muscle mass in mice remains unknown. Here, we aimed to investigate, for the first time, the effects of 6′-SL on muscle functions. Seven-week-old male C57BL/6J mice were administered 100 mg/kg 6′-SL for 12 weeks, after which exhaustive treadmill performance was conducted. Moreover, muscle strength was examined by grip strength, and muscle phenotype characteristics such as muscle mass, muscle fiber size, and muscle protein expression were also examined. The administration of 6′-SL significantly improved exhaustive treadmill performance metrics, including distance and exhaustion time. Grip strength was also increased by 6′-SL administration. Additionally, 6′-SL increased muscle mass in both the gastrocnemius (GAS) and soleus. 6′-SL administration led to an increase in the minimum Feret’s diameter and the protein expression of total myosin heavy chain in the GAS muscle. In conclusion, 6′-SL administration in vivo led to increased running distance and time by increasing muscle mass and strength. These findings collectively indicate that 6′-SL is a potential agent for improving muscle health and exercise performance.
Low Carbon Sustainable Diet Choices—An Analysis of the Driving Factors behind Plant-Based Egg Purchasing Behavior
Authors: Li Ping , Lin I-Kai , Chen Han-Shen
Published: August 2024

In the face of escalating climate change, environmental pollution, and global crises, plant-based eggs are a viable solution for environmental conservation and health promotion. This study uses an integrated framework combining value-belief-norm (VBN) theory and the Theory of Planned Behavior (TPB) to explore the factors influencing Taiwanese consumers’ inclination towards plant-based eggs. Through convenience sampling, 417 questionnaires were issued and 387 valid responses were received, indicating a 92.8% valid response rate. The analysis indicates that consumers’ biospheric and altruistic values significantly enhance their awareness of outcomes, which, coupled with their sense of responsibility, strengthens personal norms. From the TPB perspective, perceived behavioral control is identified as a critical driver of the intention to purchase plant-based eggs, with attitudes and subjective norms playing significant roles. Subjective norms positively impact personal norms, thereby influencing consumers’ behavioral intentions. The findings confirm the integrated model’s theoretical and practical validity, and offer valuable insights for businesses. By developing adept marketing strategies that consider market dynamics, this study enhances the effectiveness and value of marketing efforts by boosting consumers’ engagement with plant-based eggs. These insights contribute to advancing environmental sustainability goals.
Mediterranean Diet in Older Irish Adults: Prevalence, Patterns, Predictors and Pertinence
Authors: Norton Catherine , Clarke Elaine , Marcos-Pardo Pablo J. , Tierney Audrey
Published: August 2024

The Mediterranean diet (MD) shows the strongest evidence in support of healthy aging and prevention of age-related diseases. It is associated with a decreased risk of chronic disease, such as cardiovascular disease, obesity, hypertension, diabetes mellitus and cognitive disease. Given the health-promoting aspects of this diet, we conducted a secondary analysis of data from the LifeAge study (“Promoting the shift: sedentary Lifestyle towards active Ageing-LifeAge” Project No 603121-EPP-1-2018-1-ES-SPO-SCP) with the primary aim to determine the proportion of older Irish adults adhering to the MD and to examine the association between adherence to the MD (assessed using the Mediterranean Diet Adherence Screener (MEDAS) scoring tool) and anthropometric risk factors of non-communicable diseases. Of the 131 eligible participants (71.8% female, n = 94) (medically well, aged > 50 years and physically independent) (mean age = 66.2 ± 6.5 years), the mean cumulative MD score across the cohort was 5.8 ± 2.2, with 41% classified as moderate-to-high MD adherers (scoring > 7 MEDAS). Females had a significantly higher score compared to males (female 6.24 ± 1.98; male 4.86 ± 2.53; p = 0.002). Age (y), waist circumference (cm) and waist–hip ratio (WHR) each had a significant (p < 0.05) weak and negative correlation with MD score (r = −0.193, −0.240, −0.284, respectively). Visceral fat level had a significant (p < 0.05) moderate and negative correlation with MD score (r = −0.327). This analysis is the first to assess adherence to the MD in older Irish adults. MD adherence was lower in the Irish older cohort than that reported in older adults in Mediterranean regions and was adhered to more by females and those with a more favourable anthropometric profile. The health-promoting aspects of the diet are evident in non-Mediterranean regions as is demonstrated by the lesser incidence of some non-communicable diseases in moderate-to-high adherers. With the evidence of the protective effects of the MD, external to Mediterranean regions, it would be helpful to establish limitations to adherence, especially in aging populations living in non-Mediterranean regions.
Interferometrically Enhanced Intensity and Wavelength Modulation in Tunable Diode Laser Spectroscopy
Authors: Vervoort Sander , Wolff Marcus
Published: August 2024

Tunable diode laser spectroscopy (TDLS) is a measurement technique with high spectral resolution. It is based on tuning the emission wavelength of a semiconductor laser by altering its current and/or its temperature. However, adjusting the wavelength leads to a change in emission intensity. For applications that rely on modulated radiation, the challenge is to isolate the true spectrum from the influence of extraneous instrumental contributions, particularly residual intensity and wavelength modulation. We present a novel approach combining TDLS with interferometric techniques, exemplified by the use of a Mach–Zehnder interferometer, to enable the separation of intensity and wavelength modulation. With interferometrically enhanced intensity modulation, we reduced the residual wavelength modulation by 83%, and with interferometrically enhanced wavelength modulation, we almost completely removed the residual derivative of the signal. A reduction in residual wavelength modulation enhances the spectral resolution of intensity-modulated measurements, whereas a reduction in residual intensity modulation improves the signal-to-noise ratio and the sensitivity of wavelength-modulated measurements.
Efficient Depth Measurement for Live Control of Laser Drilling Process with Optical Coherence Tomography
Authors: Zhao Jinhan , Zhang Chaoliang , Ding Yaoyu , Bai Libing , Cheng Yuhua
Published: August 2024

Laser drilling is widely used for fabricating holes in the semiconductor industry due to high throughput and a small heat-affected zone. However, it produces varying depths owing to uncertain external conditions and requires live control at the rate of a few tens of kHz to handle the fast material removal rate. Optical coherent tomography is capable of in situ acquiring a raw interferogram at a high rate (>80 kHz), but the depth extraction is slow due to the involved heavy Fast Fourier Transform (FFT). To address this, an efficient depth-tracking algorithm is proposed to save the FFT. It searches the depth in the raw interferogram locally with a known last depth given the two truths that only one depth exists and the adjacent depths do not change significantly. The proposed algorithm was proven to expedite the measuring rate six times with sub-pixel tracking precision. To further secure the rate against the interrupting of the system, the tracking process is parallelly implemented in a field-programmable gate array. The closed-loop control tests were conducted on probe cards with depth variations introduced by offsetting laser focus. The proposed method maintained a uniform depth, with variations reduced by 80% compared to traditional methods.
Diclofenac Interacts with Photosynthetic Apparatus: Isolated Spinach Chloroplasts and Thylakoids as a Model System
Authors: Majewska Monika , Kapusta Małgorzata , Aksmann Anna
Published: August 2024

Diclofenac, often detected in environmental samples, poses a potential hazard to the aquatic environment. The present study aimed to understand the effect of this drug on photosynthetic apparatus, which is a little-known aspect of its phytotoxicity. Chloroplasts and thylakoids isolated from spinach (Spinacia oleracea) were used for this study and treated with various concentrations of diclofenac (from 125 to 4000 μM). The parameters of chlorophyll a fluorescence (the OJIP test) as measurements for both the intact chloroplasts and the thylakoid membranes revealed that isolated thylakoids showed greater sensitivity to the drug than chloroplasts. The relatively high concentration of diclofenac that is required to inhibit chloroplast and thylakoid functions suggests a narcotic effect of that drug on photosynthetic membranes, rather than a specific interaction with a particular element of the electron transport chain. Using confocal microscopy, we confirmed the degradation of the chloroplast structure after DCF treatment, which has not been previously reported in the literature. In conclusion, it can be assumed that diclofenac’s action originated from a non-specific interaction with photosynthetic membranes, leading to the disruption in the function of the electron transport chain. This, in turn, decreases the efficiency of photosynthesis, transforming part of the PSII reaction centers into heat sinks and enhancing non-photochemical energy dissipation.
The Evolution of Lipidomics during Oil Accumulation of Plukenetia volubilis Seeds
Authors: Fu Yijun , Ou Qiongjian , Ye Lixuan , You Huiyan , Wang Zhaohui , Yi Ao , Wang Jia , Niu Jun
Published: August 2024

Sacha inchi (Plukenetia volubilis) is a valuable oilseed crop with a high content of polyunsaturated fatty acids (PUFAs). However, there is a lack of in-depth understanding of the lipidomics in Sacha inchi seeds (SIDs). Saturated fatty acids occupied more than half of the proportion (59.31%) in early development, while PUFAs accounted for 78.92% at maturation. The main triacylglycerols were TAG(18:3/18:3/18:3), TAG(18:2/18:2/18:3), and TAG(16:0/18:2/18:2). The corresponding species (18:3/18:3, 18:2/18:2, and 16:0/18:2) were also the main ingredients in diacylglycerol and phosphatidic acid, indicating high PUFA composition in the sn-1 and sn-2 positions of TAG. Only LPC(18:3), LPC(18:2), and LPC(16:0) were identified in SIDs, implying that those PUFAs on the sn-2 positions of the PC(18:3/-), PC(18:2/-), and PC(16:0/-) categories were released into the acyl-CoA pool for the Kennedy pathway. Conversely, the PC(18:1/-) and PC(18:0/-) categories might be responsible for the generation of PC-derived DAG and TAG. The lipidomics data will contribute to understanding the TAG assembly in developing SIDs, especially for PUFAs.
Amaranth Plants with Various Color Phenotypes Recruit Different Soil Microorganisms in the Rhizosphere
Authors: Lin Xin-Ru , Yang Da , Wei Yu-Fei , Ding Dian-Cao , Ou Hui-Ping , Yang Shang-Dong
Published: August 2024

To explore and utilize the abundant soil microorganisms and their beneficial functions, high-throughput sequencing technology was used to analyze soil microbial compositions in the rhizosphere of red and green amaranth varieties. The results showed that significant differences in soil microbial composition could be found in the rhizosphere of amaranth plants with different color phenotypes. Firstly, soil bacterial compositions in the rhizosphere were significantly different between red and green amaranths. Among them, Streptomyces, Pseudonocardia, Pseudolabrys, Acidibacter, norank_ f_ Micropepsaceae, Bradyrhizobium, and Nocardioides were the unique dominant soil bacterial genera in the rhizosphere of red amaranth. In contrast, Conexibacter, norank_f_norank_o_norank_c_TK10, and norank_f_ norank_o_ norank_ c_AD3 were the special dominant soil bacterial genera in the rhizosphere of green amaranth. Additionally, even though the soil fungal compositions in the rhizosphere were not significantly different between red and green amaranths, the abundance of the dominant soil fungal genera in the rhizosphere showed significant differences between red and green amaranths. For example, unclassified_k__Fungi, Fusarium, Cladophialophora, unclassified_c__Sordariomycetes and unclassified_p__Chytridiomycota significantly enriched as the dominant soil fungal genera in the rhizosphere of the red amaranth. In contrast, Aspergillues only significantly enriched as the dominant soil fungal genus in the rhizosphere of green amaranth. All of the above results indicated that amaranth with various color phenotypes exactly recruited different microorganisms in rhizosphere, and the enrichments of soil microorganisms in the rhizosphere could be speculated in contributing to amaranth color formations.
Effects of Room-Temperature Center Gas Distributor Injection on the H2 Shaft Furnace Process: A Numerical Study
Authors: Shao Lei , Yu Hongfu , Zhao Chenxi
Published: August 2024

In the current work, a computational fluid dynamics-based model was utilized to investigate the performance of the H2 shaft furnace under a scenario where room-temperature H2 is injected through a center gas distributor (CGD) installed at the unit bottom. Modelling was conducted to simulate scenarios where the CGD operation is applied with different feed gas rates (ranging from 0 to 250 Nm3/t-pellet). The results showed that a high temperature level and thus a better internal thermochemical state can be maintained with a proper CGD gas feed rate. However, an overly high CGD feed rate (being 150 Nm3/t-pellet or a higher value) induces a detrimental scenario where the thermal energy recycled by the room-temperature CGD gas is insufficient to compensate for the decrease of sensible heat of the preheated feed gas from the bustle-pipe. This eventually results in a noteworthy chemical reserve zone of high H2 content and little solid reduction in the furnace center. A large quantity of H2 consequently remains unutilized and leaves the furnace from the top. Under the investigated conditions, the final solid reduction degree rises to maximal value when the CGD gas feed rate is 100 Nm3/t-pellet. The findings of this work revealed that the room-temperature CGD gas injection operation holds significant promise for practical applications.
Novel Landfill-Gas-to-Biomethane Route Using a Gas–Liquid Membrane Contactor for Decarbonation/Desulfurization and Selexol Absorption for Siloxane Removal
Authors: da Cunha Guilherme Pereira , de Medeiros José Luiz , Araújo Ofélia de Queiroz F.
Published: August 2024

A new landfill-gas-to-biomethane process prescribing decarbonation/desulfurization via gas–liquid membrane contactors and siloxane absorption using Selexol are presented in this study. Firstly, an extension for an HYSYS simulator was developed as a steady-state gas–liquid contactor model featuring: (a) a hollow-fiber membrane contactor for countercurrent/parallel contacts; (b) liquid/vapor mass/energy/momentum balances; (c) CO2/H2S/CH4/water fugacity-driven bidirectional transmembrane transfers; (d) temperature changes from transmembrane heat/mass transfers, phase change, and compressibility effects; and (e) external heat transfer. Secondly, contactor batteries using a countercurrent contact and parallel contact were simulated for selective landfill-gas decarbonation/desulfurization with water. Several separation methods were applied in the new process: (a) a water solvent gas–liquid contactor battery for adiabatic landfill-gas decarbonation/desulfurization; (b) water regeneration via high-pressure strippers, reducing the compression power for CO2 exportation; and (c) siloxane absorption with Selexol. The results show that the usual isothermal/isobaric contactor simplification is unrealistic at industrial scales. The process converts water-saturated landfill-gas (CH4 = 55.7%mol, CO2 = 40%mol, H2S = 150 ppm-mol, and Siloxanes = 2.14 ppm-mol) to biomethane with specifications of CH4MIN = 85%mol, CO2MAX = 3%mol, H2SMAX = 10 mg/Nm3, and SiloxanesMAX = 0.03 mg/Nm3. This work demonstrates that the new model can be validated with bench-scale literature data and used in industrial-scale batteries with the same hydrodynamics. Once calibrated, the model becomes economically valuable since it can: (i) predict industrial contactor battery performance under scale-up/scale-down conditions; (ii) detect process faults, membrane leakages, and wetting; and (iii) be used for process troubleshooting.