bluuebunny/crossref_metadata_2025 huggingface dataset:
The Marshall-Olkin Extended Gumbel-weibull Distribution: Properties And Applications
Authors: Nwezza Elebe Emmanuel , Ugwuowo Fidelis Ifeanyi
Published: August 2021

We introduce a new lifetime distribution called Marshall-Olkin extended Gumbel-Weibull. Some properties of distribution such as moments, TL-moments, quantile function, en- tropy, and order statistics are studied. The fexibility of the distribution to model unimodal, monotone shapes as well as unimodal, bimodal, monotone failure rates are presented. The estimators of the parameters of the distribution were obtained using the maximum likeli- hood estimation method. The performance of the maximum likelihood estimates of the Marshall-Olkin extended Gumbel-Weibulll parameters was observed through simulation studies. Two real life applications to illustrate the potentials of the new distribution are presented, and comparison with other distribution having the same baseline is done using goodness-of-test statistics.
The Primary Pitfalls on the Road to Understanding Consciousness
Authors: K Sipfle
Published: August 2021

Consciousness and the human mind have been pondered for centuries [1,2]. Today the most fundamental, likely outlines of the explanation of consciousness are known, and from this landscape we are well-positioned to fill in the basket of specific theories that will include the correct one. However, many errors in thinking and assumptions have accumulated, and even gained fashion, that obscure our progress. It is time to eliminate these, which we do herein by enumerating the complementary true assertions. Following that we mention four principles for choosing direction for further work. We conclude with a framework for further progress.
Encephalopathy Associated with Ifosfamide Use in the Treatment of Patient with Diffuse Large B Cell Lymphoma
Authors: NS Darwich , I Mustafa
Published: August 2021

Ifosfamide-Related Encephalopathy (IRE) is a unique neurotoxic side effect of ifosfamide that can occur during or after its administration. The exact underlying mechanism responsible for the development of IRE is not yet known; however, mitochondrial toxicity from one or more ifosfamide metabolites has been proposed. Most cases of IRE are mild and resolve spontaneously with discontinuation of ifosfamide in addition to supportive care, but some patients progress to severe encephalopathy with the risk of seizure, coma, and even death. Electroencephalogram (EEG) abnormalities with or without apparent clinical neurotoxicity symptoms develop in a high percentage of patients treated with ifosfamide, with diffuse slowing being the most common finding; in addition, generalized periodic discharges, triphasic waves, periods of suppression, and patterns consistent with nonconvulsive status epilepticus have also been reported.
Peripheral Facial Paresis and COVID-19 Case Report
Authors: M Militaru , DF Lighezan , MN Petrescu , AG Militaru
Published: August 2021

Among the neurological complications that occurred during Corona Virus Disease 2019 (COVID-19) infection, peripheral facial paresis is one of the conditions that can occur both during and after the Severe Acute Respiratory Tract Syndrome Corona Virus 2 (SARS-CoV-2) infection period. We present the case of a young man, aged 29 years, who presented the appearance of a peripheral facial paresis on the 14th day after the onset of symptoms, isolation and PCR detection of SARS-CoV-2 infection. The patient was evaluated clinically, neurologically, underwent laboratory tests, EKG, chest Radiography, Magnetic Resonance Imaging (MRI)/Magnetic resonance Angiography (MRA) and received corticotherapy, gastric antisecretory medication, antiviral medication, vitamin B group, neurotrophic medication and facial gymnastics, with good evolution and complete remission of clinical symptoms after 21 days. It is particularly important to carefully evaluate patients during the isolation period, symptomatic/asymptomatic for COVID-19 infection, as a possible complication could be peripheral facial paresis, which is why, we should evaluate, detect and treat early to reduce any persistent long-term neurological effects. Future studies are needed to identify and correlate peripheral facial paresis with SARS-CoV-2 infection as well as to detect the causes of neurological complications during or after COVID-19 infection.
Precipitating Factors of Psoriasis in North Indian Population
Authors:   Consultant, Department of Skin & V.D., District Hospital Gazipur, Uttar Pradesh India, Bhaskar Dr. Kamlesh Kumar
Published: August 2021

Aim: This study aims to study precipitating factors of psoriasis in the north Indian population.Material & Method:Two hundred twenty-eight psoriasis patients regardless of age, sex, religion,occupation, attending the skin, and V.D. outpatients Department, B.R.D. Medical College, Gorakhpurfor were taken because of the subject of this study. The bulk of patients belonged to the Eastern U.P.and adjoining areas of Bihar and Nepal. The clinical criteria for diagnosis of psoriasis were thepresence of Erythematous and papulosquamous lesions with loosely adherent silvery-white scales.The auspitz's sign was demonstrated all told the cases. The detailed clinical history and examinationwere recorded. Each patient was categorized into mild to severe psoriasis. Result: The maximumpercentage of cases was aggravated by weather (winter), 55.26%, next to that was trauma 27.19%, and least after infections 4.35%. The summer and spring seasons showed an improved effecton the condition of psoriasis. Alcohol, smoking, and mental stress found no relation with psoriasis.In most cases, where the infection was associated with the disease, it had been aggravated only inchildren, and young adults and lesions were of guttate type. Pregnancy had no effect in 25.43% ofcases, while the disease was improved in 3.50% of patients and worsen in 4.35% of cases.Conclusion: Psoriasis is positively correlated with the winter season and negatively associated withSummer and Spring.
Evaluation of Thyroid Hormone Levels in Full-Term Neonates Presented with Septic Shock
Authors:   Senior Resident, Department of Pediatrics, Gandhi Medical College, Bhopal, Madhya Pradesh, India, Singh Dr. Dhananjay , Shrivastava Dr. Jyotsana ,   Professor and HOD, Department of Pediatrics, Gandhi Medical College, Bhopal, Madhya Pradesh, India, Agrawal Dr. Amit ,   Associate Professor, Gandhi Medical College, Bhopal, Madhya Pradesh, India
Published: August 2021

Introduction: The incidence of neonatal sepsis in India is 38 per 1000 live births. Many authorsfound an association between altered thyroid hormone levels and septic shock in neonates and itmay be of prognostic importance in septic shock treatment. This study has been conducted to findthe relationship between thyroid profile and septic shock in neonates and also to compare thethyroid profile in survivor and non-survivor groups of septic shock patients. Methods: Thisanalytical prospective cohort study was conducted in the NICU of a tertiary care teaching institutionin central India. Full-term neonates with late-onset sepsis were included in this study and estimationof thyroid hormones (TSH, T3, T4, fT3, and fT4) was performed. These neonates were divided intothose with and without septic shock patients and levels of thyroid hormones were correlatedbetween these patients to find significant relations. The Vasoactive-Inotropic Score (VIS) score wascalculated. Results: A total of 195 full-term neonates were included in the study. The mean value ofTSH, T3, T4, fT3, and fT4 among neonates with septic shock were 5.27 μg/ml, 80.01 ng/dl, 6.36μg/dl, 1.40 pg/ml, and 1.40 μg/dl, respectively while the values were 5.29 μg/ml, 94.4 ng/dl, 7.25μg/dl, 1.84 pg/ml, and 1.43 μg/dl, respectively in septic neonates without shock. This difference wasstatistically significant except for TSH (p>0.05). The mean value of TSH, T3, T4, fT3, and fT4 amongseptic shock survivors were 5.27 μg/ml, 80.01 ng/dl, 6.36 μg/dl, 1.40 pg/ml, and 1.40 μg/dl and inseptic shock non-survivors were 2.40 μg/ml, 37.33 ng/dl, 3.86 μg/dl, 0.99 pg/ml, and 0.84 μg/dl,respectively (p<0.0001). Only T3 was found to be significantly co-related with VIS in septic shock inall the groups (<0.001). Conclusion: Our study suggests that TSH, T3, T4, fT3, and fT4 levels aresignificantly low in patients suffering from the septic shock which may vary in the case of TSH. Also,there is a significant decrease in thyroid profile among septic shock non-survivors as compared tosurvivors.
Defining of the Minimum Wavelet Filter Coefficients Bit-Width for 3D Medical Imaging
Authors:   North-Caucasus Federal University, Stavropol, 355017, Russian Federation, Nagornov N. N.
Published: August 2021

Medical imaging uses a variety of modalities to provide visual information about a patient. Various methods are used to process this data. Many of them are based on discrete wavelet transform (DWT). Its use will allow effective denoising and compression of 2D and 3D images. This paper proposes a new approach to linear time-invariant wavelet filtering using quantized filter coefficients when using which the computational errors have different signs and allow to partially compensate each other as a result of which the processed image is of high quality. The analysis of the quantization noise of the direct multilevel DWT filter coefficients is carried out. The derived formulas demonstrate the relationship between the quantization accuracy of these coefficients and the processing quality of digital 3D images. The derived formulas for calculating the minimum accuracy of the wavelet filter coefficients representation in the computing devices memory allow minimizing the effect of quantization noise on the result of 3D images processing. Modelling of 3D medical tomographic images DWT processing showed that a decrease in the ratio of the average voxel brightness to the maximum allowable value with increasing color depth of images leads to faster achievement of high quality compared to the results of theoretical analysis with an increase in the value of the scaling degree of the wavelet filter coefficients. The obtained theoretical and practical results open up the possibility for reducing the computational complexity of software and hardware implementation of wavelet processing of 3D medical visual data on modern microelectronic devices (field-programmable gate arrays, application-specific integrated circuits, etc.).
HISTORIOGRAPHY OF THE STUDY OF THE FORMATION AND DEVELOPMENT OF HIGHER EDUCATION IN CHERNIHIV REGION
Authors: Kuzmenko Nadiya
Published: August 2021

The historiography of the development of higher education in Chernihiv region is considered, the pre-Soviet, Soviet and modern stages of this
problem are determined; it was found that researchers of the genesis of higher education in Chernihiv region paid great attention to studying the date
of establishment, financing and functioning of the Chernihiv Collegium; it was defined that the development of higher education in Chernihiv region
was considered by researchers through the study of two components: the system of educational institutions and educational, philanthropic and
pedagogical activities of prominent personalities of Chernihiv region.
It was found that the Chernihiv Collegium (1700-1786) was the first institution of secondary education in the Left Bank of Ukraine, whose activities
were of great importance for the formation and development of the domestic system of higher education. The question of the history of one of the
Ukrainian Orthodox colleges was the subject of study by researchers of the XIX century P. Bogoslovsky, M. Dokuchaev, V. Lytynsky, O. Shafonsky.
In the first half of the XIX century some information about the Chernihiv Collegium was contained in the works of V.Askochensky, D. BantyshKamensky, M. Bulgakov, M. Markov, M. Markevich. The introduction into scientific circulation of significant archival material on the history of the
college began in the second half of the XIX century, the first articles by A. Starodomsky appeared. F. Gumilevsky's works contained factual material
that revealed various aspects of the history of the college, educational and philanthropic activities of its founders. A selection of archival materials
on the history of the college of researchers M. Blagoveshchensky P. Dobrovolsky S. Nikolsky was published in the local press in the late nineteenth –
early XX century; scientific researches of the history of the educational process of Chernihiv region were intensified (O. Andriyashev, O. Vvedensky,
P. Wojciechowski, M. Golik, F. Dmytrevsky, P. Dobrovolsky, M. Domontovych, M. Zhdanovych P. Korobka, O. Musin-Pushkin O. Rusov, S. Rusova,
M. Sukhomlinov, M. Tutomlin, V. Khyzhnyakov, E. Shulga). Scientists of the Soviet period studied various aspects of the development of education
in Chernihiv region in the context of the genesis of education in Ukraine (V. Borysenko M. Zavoloka J. Isayevach, B. Mityurov S. Siropolko
Z. Khyzhnyak, N. Ship). The modern period of historiography of the study of the development of higher education in Chernihiv region is presented in
the works of A. Borovik, N. Kuzmenko, O. Pronikov, O. Travkina.
FORMATION OF MANAGEMENT COMPETENCE AS A VALUE OF A FUTURE HIGHER EDUCATION TEACHER
Authors: Levytska Liudmyla
Published: August 2021

The essence of the definitions "competence", "managerial competence" as the value of the future teacher of higher education and the object of
scientific analysis is revealed; "value professional orientations" as a result of awareness and assimilation of universal and professional values and
the basis for the formation of managerial competence of future specialists in higher school pedagogy. Values are outlined as a qualitative criterion
of professionalism of the future specialist, which determines the vector of needs, interests, position and level of development of the individual and
his professional self-determination. "Professional competence" is highlighted as the basis of effective management.
The managerial competence of a teacher of a higher education institution is revealed as an integrative quality of a specialist in the field of higher
school pedagogy, which reflects his ability to lead the educational process and communication in a professional environment and is a high level of
professionalism.
The peculiarities of the formation of managerial competence of a teacher in higher education are clarified. The pedagogical conditions of formation of
managerial competence of the future teacher of higher school in the course of master's preparation are defined; the educational environment of the higher
education institution is defined as an important condition for the formation of managerial competence and professional and value orientations of students;
criteria for the formation of managerial competence of the future teacher in the process of master's training are revealed.
A comparative analysis of the relationship between stature and ultrasound dimensions of internal organs in adolescents
Authors: Yerkudov Valerii O. , Pugovkin Andrey P. , Volkov Aleksej J. , Musaeva Oksana I. , Volkov Dmitriy J. , Rogozin Sergej S. , Chistjakova Mar’jana V. , Kochubeev Andrej V. , Pakhomova Maria A. , Brus Tatiana V. , Zabezhinsky Mikhail M.
Published: August 2021

The aim of the study was a comparative characteristic of the size of internal organs according to ultrasonography data in subjects with various deviations in stature, determined using international standardized norms. Materials and methods. The stature was measured in 93 adolescents, aged 13 to 17 years. Based on the measurements, the Z-score of body length was calculated according to the WHO Growth Reference, 2007 and three groups were formed for comparing the sizes of internal organs: average, above average, below average. Ultrasonography data of the internal organs dimensions and thyroid gland was performed using a Toshiba Aplio 500 ultrasound scanner. Results. There were statistically significantly lower values of the liver span and the longitudinal size of the gallbladder in the examined subjects from the below average group compared to the rest of the subjects. The length of the spleen and the total volume of the thyroid gland were statistically significantly different in subjects from all three groups, with the highest values in volunteers from the above average group. A weak direct correlation was shown between the Z-score of body length and liver span, the length of the cauda of the pancreas, and the width of the spleen. An average direct statistical relationship was found between the Z-score of stature and the length of the spleen, as well as the total volume of the thyroid gland. Conclusion. To a greater extent, body length is associated with the size of the parenchymal organs with a pronounced connective tissue frame - the liver and spleen, as well as the thyroid gland due to the relationship of its volume with hormones that regulate growth and development. Clinical substantiation of the relationship between the structure of the body and internal organs opens up the possibility of creating anatomical standards that allow ultrasound morphometric assessment of internal organs, taking into account the individual characteristics of the patients body size.
Morphofunctional features of platelets in premature newborns with very low and extremely low body weight
Authors: Budalova Anastasia V. , Kharlamova Natalia V. , Kuzmenko Galina N.
Published: August 2021

Background. Currently, the development of medicine in the field of perinatology is aimed at improving the quality of medical care for newborns, especially those born prematurely. Premature newborns are most likely to develop hemorrhagic disorders, which often aggravates their condition and determines high morbidity and mortality. On modern hematological analyzers, it has become possible to evaluate a larger number of blood parameters, including platelet parameters, however, there are a small number of studies devoted to the study of platelet parameters in premature newborns. The aim was to study the morphofunctional features of platelets in premature newborns with very low and extremely low body weight. Materials and methods. The study included 78 newborns born at 2534 weeks of gestation, with a body weight of less than 1500 grams. On the 3rd5th day of life, a clinical blood test was performed on the Advia 2120i hematological analyzer (Siemens), with the determination of platelet parameters: PLT, 103 cells/l, PCT, %, PDW, %, Large Plt, 103 cells/l, MPC, g/dl, MRM, pg. Results. In newborns with ELBW, a decrease in the number and granularity of platelets in the blood, an increase in the average dry mass of platelets was found. Newborns with intrauterine growth retardation have a reduced platelet count and reduced thrombocrit. In premature newborns with a gestational age of 2527 weeks, blood circulation of platelets with a reduced volume was established, and in newborns who were born at a gestational age of 3234 weeks with increased granularity. In the absence of antenatal prevention of respiratory distress syndrome in newborns, there is a decrease in thrombocrit, the number of platelets, including large forms in the blood. In premature newborns born in a state of severe asphyxia, a decrease in platelet granularity was noted. The use of high concentrations of O2 in the oxygen-air mixture during respiratory therapy leads to a decrease in the number of platelets in the blood. Conclusions. Factors determining the morphofunctional state of platelets in premature newborns were established: the presence of a full course of antenatal prevention of respiratory distress syndrome of newborns, gestational age, the severity of asphyxia at birth, as well as the concentration of O2 in the oxygen-air mixture used in respiratory therapy. Newborns with ELBW have a reduced platelet count, low-granulated platelets, and an increased average dry platelet mass. Newborns with intrauterine growth retardation have a reduced number of platelets and thrombocrit in the blood. The revealed morphofunctional features of platelets allow us to clarify the nature of changes in the platelet link of hemostasis in premature newborns for the timely prevention of complications during the underlying disease.
A clinical case of extremely severe major venes displasia in a child
Authors: Azarov Mikhail V. , Kupatadze Dmitry D. , Nabokov Viktor V. , Makhin Yuri Y. , Kolbaia Levter М. , Dyug Igor V.
Published: August 2021

Dysplasia of the great veins (DMV) is known by the names of the authors who described this pathology as KlippelTrenone syndrome. The clinical picture of the KlippelTrenone syndrome in the classic description of the authors is characterized by a triad of symptoms: vascular spots, atypical varicose veins, hypertrophy of soft tissues and bones with an increase in the volume and length of the affected limb. It should be emphasized that the severity of these symptoms depends, first of all, on the type of lesion (embryonic or fetal) and the severity of the lesion. KlippelTrenone syndrome is almost always sporadic, meaning that it develops in people with no family history of the disorder. Research shows that this condition is due to gene mutations that are not inherited. These genetic changes, called somatic mutations, occur randomly in a single cell during the early stages of development before birth. KlippelTrenone syndrome can be caused by mutations in the PIK3CA gene. This article presents a clinical observation the course of the disease of a 1-year-old child, with an extremely severe form of dysplasia of the great veins. In the presented clinical observation, attention is drawn to the difficulties of treating this patient against the background of the underlying chronic disease. The treatment of these patients should be carried out on the basis of a multidisciplinary hospital, which includes specialists in vascular surgery, an orthopedist and an intensive care physician. On the example of the described case, diagnostic tactics and surgical treatment are demonstrated. It is obvious that timely surgical and conservative treatment of pathology in children with dysplasia of the great veins improves the quality of life and social adaptation of children.
Source Characteristics of the 2019 Mw 6.5 Ambon, Eastern Indonesia, Earthquake Inferred from Seismic and Geodetic Data
Authors: Meilano Irwan , Salman Rino , Rahmadani Suchi , Shi Qibin , Susilo Susilo , Lindsey Eric , Supendi Pepen , Daryono Daryono
Published: August 2021

The 26 September 2019 Mw 6.5 Ambon earthquake has been the largest instrumentally recorded event to occur in Ambon, the capital city of Maluku Islands, eastern Indonesia, and ruptured a previously unmapped active fault. In this study, we use seismic and geodetic data to investigate the source characteristics of the event. Our results show that the rupture process was complex in both the rupture initiation and slip directions. In addition, the rupture was mostly strike-slip motion with normal component and pure reverse slip in the north of the inverted fault. Our analysis of campaign and continuous Global Positioning System (GPS) velocity fields estimates that the fault has a 4.9 [4.0, 5.5] mm/yr slip rate with an earthquake recurrence interval of 115 [102, 141] yr. In addition, a comparison of the horizontal strain-rate tensor derived from GPS velocity fields with historical earthquake data shows that Ambon Island and the nearby regions have a high strain accumulation rate correlated with the distribution of Mw≥6 earthquakes, indicating that the regions are seismically active and possibly will experience more Ambon-type earthquakes in the future.
Joint Inversion of Rupture across a Fault Stepover during the 8 August 2017 Mw 6.5 Jiuzhaigou, China, Earthquake
Authors: Zhang Yong , Feng Wanpeng , Li Xingxing , Liu Yajing , Ning Jieyuan , Huang Qinghua
Published: August 2021

The 8 August 2017 Mw 6.5 Jiuzhaigou earthquake occurred in a tectonically fractured region in southwest China. We investigate the multifault coseismic rupture process by jointly analyzing teleseismic, strong-motion, high-rate Global Positioning System, and Interferometric Synthetic Aperture Radar (InSAR) datasets. We clearly identify two right-stepping fault segments and a compressional stepover based on variations in focal mechanisms constrained by coseismic InSAR deformation data. The average geometric parameters of the northwest and southeast segments are strike = 130°/dip = 57° and strike = 151°/dip = 70°, respectively. The rupture model estimated from a joint inversion of the seismic and geodetic datasets indicates that the rupture initiated on the southeastern segment and jumped to the northwestern segment, resulting in distinctive slip patches on the two segments. A 4-km-long coseismic slip gap was identified around the stepover, consistent with the aftershock locations and mechanisms. The right-stepping segmentation and coseismic rupture across the compressional stepover exhibited by the 2017 Jiuzhaigou earthquake are reminiscent of the multifault rupture pattern during the 1976 Songpan earthquake sequence farther south along the Huya fault system in three successive Ms∼7 events. Although the common features of fault geometry and stepover may control the similarity in event locations and focal mechanisms of the 2017 and 1976 sequences, the significantly wider (~15 km) stepover in the 1976 sequence likely prohibited coseismic rupture jumping and hence reduced seismic hazard.
Clubfoot: current concept of treatment
Authors:   Vittore Buzzi Children’s Hospital, Milano, Italy, Andreacchio A. , Alberghina F. ,   Regina Margherita Children’s Hospital, University of Torino, Torino, Italy, Monforte S. ,   Vittore Buzzi Children’s Hospital, Milano, Italy, Dimeglio A. ,   Clinique St. Roch, Montpellier, France, Canavese F. ,   Lille University Center, Jeanne de Flandre Hospital, Nord-de-France University, Lille, France
Published: August 2021

Introduction Idiopathic clubfoot (IC), also referred to as congenital talipes equinovarus, is one of the most common lower limb deformities observed in newborns, leading to significant functional impairment when left untreated. Early minimally invasive treatment has been praised as one of the most successful practice of modern pediatric orthopedics. This review aims to report current knowledge and controversies about clubfoot treatment. Material and methods We describe the main trends in clubfoot managing, identifying peculiarities, difficulties and prognostic factors related to the treatment. Results Many treatment techniques either conservative, surgical or hybrid have been used over the past decades. Based on good and excellent results during long-term follow-up, Ponseti method has been globally accepted by paediatric orthopaedic surgeons as standard method of treatment. However, some other conservative methods are still widely applied in the clinical setting, such as the French Physical Therapy method. Adherence to the bracing protocol is critical for the long-term success of the treatment, being a better predictor for relapse than severity of the deformity at birth. Conclusions Taking care of the manipulation and casting details by trained professionals, together with enhancing the child and patents’ adherence to the brace, are essential for the success of conservative treatment. Surgery should be performed only when strictly needed, preferably on a “a la carte” approach.
Osteogenesis imperfecta: current issues of etiology, pathogenesis, classification (systematic review)
Authors:   Ilizarov National Medical Research Centre for Traumatology and Orthopedics, Kurgan, Russian Federation, Ryabykh S.O. , Popkov D.A. ,   Ilizarov National Medical Research Centre for Traumatology and Orthopedics, Kurgan, Russian Federation, Shchurova E.N. ,   Ilizarov National Medical Research Centre for Traumatology and Orthopedics, Kurgan, Russian Federation, Ochirova P.V. ,   Ilizarov National Medical Research Centre for Traumatology and Orthopedics, Kurgan, Russian Federation, Ryabykh T.V. ,   Ilizarov National Medical Research Centre for Traumatology and Orthopedics, Kurgan, Russian Federation
Published: August 2021

The constantly changing information about the genetic nature of osteogenesis imperfecta (OI), new approaches to classification and diagnosis, and the growing interest in this pathology require careful analysis and generalization of the available data in the recent literature. Purpose Analysis of recent literature on epidemiology, pathogenesis, etiology, classification of osteogenesis imperfecta. Materials and methods The literature search was carried out in the scientific literature databases of PubMed, Web of Science, Scopus, eLIBRARY, RSCI, and references of the key works. The following inclusion criteria were used: literature reviews, review articles, multicenter studies, cohort studies of patients with osteogenesis imperfecta. Results This systematic review included 18 publications that met the inclusion criteria. All selected publications were published within the period from 2012 to 2020. The study designs were review articles or literature reviews. Discussion Osteogenesis imperfecta is one of the most common types of skeletal dysplasia, a phenotypically and genetically heterogeneous group of hereditary bone diseases. OI is characterized by high variability of manifestations, even within the same type and one family. The results of the analysis of the prevalence of this disease in different population groups remain not fully covered. The degree of genetic heterogeneity of the disease has not yet been determined. Research is ongoing to identify new genes involved in the pathogenesis of OI. The introduction of modern methods for determining mutations in genes contributed to the progress of research into the molecular pathogenesis of osteogenesis imperfecta, and identification of new genes, mutations in which lead to OI. The large number of causative genes complicates the process of creating an optimal classification of OI. The difficulty of creating a comprehensive classification of OI subtypes is the fact that there is no clear phenotype-genotype relationship; based on the mutation, conclusions about its clinical severity cannot be drawn. Conclusion The classification of various types of osteogenesis imperfecta is still the subject of ongoing debate and research.
Prevalence of adenomyosis and associated gynaecological pathologies in hysterectomy samples: a retrospective study
Authors: Gopinath Lekshminath , Vaidya Rajani
Published: August 2021

Background: Adenomyosis is a prevalent gynaecological disorder among women and it is a major cause for AUB. Its diagnosis is confirmed by histological examination of hysterectomized samples. Moreover it is associated with other benign gynaecological pathologies. The aim of this study is to identify the prevalence of Adenomyosis and its association with other benign gynaec pathologies in hysterectomized samples.Methods: This retrospective of two year duration was conducted in obstetrics and Gynaecology department of Malabar Medical College Hospital and Research Centre, a tertiary care centre in Kozhikode, Kerala from 2019 June to 2021 June. 452 patients underwent hysterectomy for abnormal uterine bleeding during this period. Among this, 76 patients had histologically proven adenomyosis in hysterectomy specimen and their case record were reviewed and the data was analysed.Results: The prevalence of Adenomyosis in this study was 16.8%. Majority of women were in age group of 41 to 46 (36.8%), followed by 46 to 50 age group (26.3%). 94 % of women were multipara with majority in para2 and para3 group. Only 6 % of women were nulliparous. Most common symptom was abnormal uterine bleeding (92%), followed by dysmenorrhoea and chronic pelvic pain. Majority had overlap of symptoms. 7% of women were asymptomatic. In 60 % of women no other gynaec pathologies were identified. Most common associated pathology was leiomyoma (15.8%), closely followed by endometriosis (13.2%). Endometrial hyperplasia was associated with adenomyosis in 3.9%of women and endometrial polyp in 2.6%. Ovarian pathologies identified were simple ovarian cyst (2.6%) and serous cystadenoma (1.3%).Conclusions: In the present study, the prevalence of adenomyosis was high and abnormal uterine bleeding was the patients’ most prevalent complaint. Among the associated gynaec pathologies, leiomyoma had the highest correlation with adenomyosis.
Open bile duct exploration as a therapeutic solution for difficult to manage choledocholithiasis: a case report
Authors: Olivares Eduardo Poblano , Perez Brenda Soto , Gonzalez Jorge L. Olmos
Published: August 2021

The most common etiology of bile duct obstruction in patients with cholelithiasis is choledocholithiasis. The diagnosis of cholelithiasis is based on clinical suspicion and confirmed by ultrasound (US) of the liver and bile ducts. The management of bile duct lithiasis has evolved considerably and currently, ERCP is the most common and recommended technique. However, in cases of multiple lithiases, fragmentation of the lithiasis during extraction, excessive preoperative or transoperative handling of the ampullary region, previous stenosis of the ampullary region, juxtapapillary diverticula, primary bile duct stones, or residual intrahepatic stones, a large number of hospitals do not have sufficient resources to perform minimally invasive procedures and offer these therapeutic alternatives instead.
Контролируемые системы доставки на основе полимерных 3D-скаффолдов, полученных методом электроспиннинга
Authors: Савостьянова Т.А.
Published: August 2021

В статье рассматривается получение биосовместимых полимерных 3Dскаффолдов с помощью технологии электроспиннинга и их применение в качестве систем для контролируемой доставки различных биоактивных агентов. Описываются трансдермальные, быстрорастворимые, «интеллектуальные» и имплантируемые системы доставки на основе полимерных скаффолдов и дается оценка их перспективности в качестве материалов для областей контролируемой доставки биоактивных агентов и регенеративной медицины.
Современные особенности клинического течения туберкулезного артрита
Authors: Сердобинцев М.С. , Кобыфа А.А. , Бердес А.И. , Соколович Е.Г. , Яблонский П.К.
Published: August 2021

В работе представлены основные особенности клинических проявлений туберкулеза суставов, сроки установления диагноза, стадийность специфического процесса, сопутствующая патология и осложнения хирургического лечения. Полученные данные будут важны для правильного планирования лечебнодиагностической стратегии в отношении больных костно-суставным туберкулезом.
Применение модельно ориентированных технологий
Authors: Агаширинова В.Ю. , Белова О.Ю.
Published: August 2021

В данной статье рассмотрены основные аспекты применения модельно ориентированных технологий при проектировании систем.
Исследование модели графа для построения маршрутов кабельных трасс для машиностроительных проектов
Authors: Гусак Е.В. , Гурьев А.Т.
Published: August 2021

В статье рассматривается несколько подходов к графу маршрута кабельной трассы в задаче трассировки кабелей. Описываются их отличительные черты, а также преимущества и недостатки.
Практические приѐмы создания виртуального коворкинга для разработчиков программного обеспечения
Authors: Шевелев А.М. , Рысин М.Л.
Published: August 2021

В статье рассматриваются этапы создания элементов виртуального коворкинга для разработчиков программного обеспечения. Авторами была показана структура типовой организации, разрабатывающей программное обеспечение, проанализированы требования к системе виртуального коворкинга, спроектирована архитектура программной системы, реализованы еѐ компоненты.
Установка недеформирующего торможения пуль короткоствольного огнестрельного оружия
Authors: Захаров И.В.
Published: August 2021

В статье показана разработанная установка контрольного отстрела короткоствольного огнестрельного оружия, обеспечивающая недеформирующее торможение пуль, позволяя надѐжно выявить и сохранить идентификационные следы от конкретного ствола оружия для работы разрешительно-лицензионного управления и федеральной пулегильзотеки.
Преимущества и недостатки роботизированных складов
Authors: Мельников С.Е. , Панюшкина А.А. , Чертовских А.С.
Published: August 2021

Данная статья посвящена роботизации складских процессов. Определены положительные и отрицательные моменты внедрение роботов на склад. Актуальность темы обусловлена тем, что в настоящее время многие люди вынуждены трудиться на складах крупных фирм на низкооплачиваемой, физически тяжелой работе. Повышение грузопотоков остро ставит проблему автоматизации складских и логистических операций.
Геометрические методы решения задач теории пластинок
Authors: Фетисова М.А. , Абдурагимов А.Р. , Ёрмамадов Х.П.
Published: August 2021

В статье идет речь о геометрических методах для расчета задач теории пластинок. Изопериметрический метод, раскрытый известными американскими математиками Д. Пойа и Г. Сеге применительно к различным задачам математической физики, суть метода заключается в построении двухсторонних изопериметрических неравенств при оценке интегральных физических характеристик пластинок различных форм.
Роль инвестиций в развитии организации
Authors: Акбашева Д.М. , Хачирова Ф.М. , Кундохова К.Р. , Гебенов Р.М. , Лайпанов А.А. , Хубиев Х.М.
Published: August 2021

В данной статье раскрывается понятия инвестиции, что позволяет понять его содержание, а также его классификация, и ещѐ рассматривается роль инвестиций в развитии организации. Изучение инвестиций необходимо для того, чтобы понять его сущность и место в системе управления организацией. Актуальность обсуждения данной темы является то, что увеличение объемов инвестиций позволяет обеспечить рост промышленного производства, развитие экономического потенциала.
Статистические методы в исследовании производства молока в сельскохозяйственных предприятиях Воронежской области
Authors: Борисова Д.А. , Олемская Е.И. , Панин С.И.
Published: August 2021

В статье исследуется современный уровень производства молока в сельскохозяйственных предприятиях Воронежской области. Выявляются факторы, обусловившие его изменение на основе индексного анализа. Производятся прогнозные оценки динамики поголовья коров, их продуктивности и валового производства молока.
Цифровая трансформация в сфере жилищно-коммунального хозяйства
Authors: Галушко М.В.
Published: August 2021

Целью исследования является изучение потребности инновационных разработок в сфере ЖКХ. Приведены примеры инновационных разработок ИТ- компаний и их возможное влияние на дальнейшее развитие цифровой экономики в сегменте жилищнокоммунального хозяйства. Так же были рассмотрены и выделены задачи, решение которых может положительно повлиять на развитие цифровизации ЖКХ.
Оценка уровня занятости и доходов населения в аграрной сфере Воронежской области
Authors: Ряховская Е.Н. , Трофименко А.С. , Панин С.И.
Published: August 2021

Статья посвящена анализу динамики уровня занятости населения и номинальной заработной платы в сельском хозяйстве Воронежской области. Анализ проводился на основании временных рядов динамики, посредством построения уравнений тренда динамики по девятилетней ретроспективе. Одновременно, на основании полученных функций трендов динамики в различных конфигурациях проведен прогноз доходов и уровня занятости на среднесрочный период (до 2023 г.).
Социальные сети как инструмент коммуникации: теоретико-методологический анализ
Authors: Бурачевская К.Д. , Кошелев А.А.
Published: August 2021

Данная статья посвящена исследованию социальных сетей, как общественного феномена. Цель работы - выявить основные подходы к понятию «социальные сети», а также проанализировать их значение в современном обществе. В процессе исследования авторами использовался теоретико-методологический подход, а также анализ вторичных источников. К числу основных результатов можно отнести вывод о возрастающей роли социальных сетей в обществе, а также рейтинг популярности данных ресурсов у российских пользователей.
Особенности изучения рынка молодежно-спортивного туризма
Authors: Емельянов С.С.
Published: August 2021

В данной статье рассматривается туристический рынок, который является одним из важнейших сфер жизнедеятельности молодежи.
Современные способы ремонта стальных канатов закрытой конструкции
Authors: Маслов В.Б. , Скородумов Н.В.
Published: August 2021

Статья посвящена повышению срока службы несущих стальных канатов и уровня безопасности при эксплуатации подъемно-транспортных машин, а именно канатных дорог на которых используются стальные канаты закрытой конструкции. Цель – ознакомление с разработанным и внедренным на предприятии способе ремонта кантов закрытой конструкции.
Digital technologies for monitoring and implementation of smart diagnostics of the isolation of power supply systems with isolated neutral in the operating mode
Authors: Kondrateva N.P. , Shishov A.A. , Bolshin R.G. , Krasnolutskaya M.G.
Published: August 2021

Nowadays, 75% of emergencies at power supply facilities are caused by single-phase ground faults. The currently used methods of thermal imaging and ultrasonic testing do not allow accurately identify the cause of accidents in electric power distribution systems. The current search generators, due to their low power, cannot cover the entire section of the diagnosed network. The article suggests the use of digital technologies for the intelligent diagnostics of the insulation of power supply system with insulated neutral in the operating mode, allowing on-line diagnostics of the network and analyzing the data obtained for the early prevention of emergency situations. In order to avoid disconnecting sections and diagnose the system in operating mode, it is proposed to check the system using a currentlimiting capacitor, which will be connected to the live parts of each phase under voltage and accurately determine the location of a single-phase short circuit for any number of feeders. The relevance of these studies is due to the fact that, for example, during two years at one of the manufactures 19 emergencies related to single-phase ground faults were recorded. Four of these cases led to a complete stop of the production. Therefore, the development of digital technologies for the implementation of smart diagnostics of the insulation of an energized power supply system with insulated neutral will be of interest to practitioners, scientists, researchers, graduate students and other specialists seeking to study the latest achievements in smart agribusiness for their subsequent application in the real world.
Разновидности муки, используемые в приготовлении печенья
Authors: Родионова А.С. , Иванова Н.Н. , Иванов Д.И.
Published: August 2021

Мука является основным ингредиентом при приготовлении печенья. От еѐ сорта и качества будут зависеть органолептические качества кондитерских изделий. Для расширения ассортимента, улучшения органолептических показателей качества печенья можно применять кукурузную, овсяную и пшенную муку.
Сравнительная характеристика качества сахарного печенья «Барышня земляничка», приготовленного из нетрадиционных видов муки
Authors: Родионова А.С. , Иванова Н.Н. , Иванов Д.И.
Published: August 2021

Использование других видов муки в мучных кондитерских изделиях, в том числе на предприятиях общественного питания, позволяет повысить пищевую ценность изделий, что благоприятно скажется на здоровье человека. В процессе исследования получен образец печенья лучшего качества с добавлением пшенной муки.
Районирование Тихоокеанского ландшафтного пояса России как ландшафтной основы к пространственному развитию геосистемы Восточная Россия-Мировой океан
Authors: Старожилов В.Т.
Published: August 2021

Работа представляет собой продолжение комплексных исследований в целом сформировавшейся ландшафтной школы профессора В.Т. Старожилова (doi:10.24411/1728-323Х-2020-13079, doi:10.18411/lj-05-2020-26). Рассматривается районирование Тихоокеанского ландшафтного пояса России (doi: 10.18411/lj-01-2021- 32), включающего Сихотэ-Алинскую, Нижнеамурскую, Камчатско-Курильскую, Сахалинскую и другие ландшафтные территории и сопряженные с ними окраинные моря. Констатируется, что на основе применения ландшафтной методологии, на основе сопряженного анализа и синтеза межкомпонентных и межландшафтных связей с учетом окраинно-континентальной дихотомии и данных по орогеническому, орографическому, климатическому и фиторастительному факторам формирования географически единых территорий в рамках горного ландшафтоведения, проведено районирование Тихоокеанского ландшафтного пояса (Российская часть) и выделены округа, провинции и области. Оно является одной из базовых моделей «фундаментом» для построения гармонизированных с природой и связанных с океаном экологических, сельскохозяйственных и других отраслевых моделей освоения, в целом пространственного развития геосистемы Восточная Россия-Мировой океан. Отмечается, что при исследовании применялись компьютерные технологии векторно-слоевого ландшафтного метода, которые в свою очередь создают платформу для разработки планов и проектов освоения. Они также является платформой для обучения студентов. Приводятся данные о картографической обеспеченности современными векторно-слоевыми цифровыми материалами.
A Critical Analysis of the Baṭn (esoteric meaning) Theory in Tafsīr al-Mīzān, with Regard to Tafsīr al-Furqān
Authors: Narimani Zohreh
Published: August 2021

The commentators and traditionists have long focused on the theory that Qur’ān has multiple Buṭūn (esoteric meanings). Most of the commentators believe that the Baṭn can be revealed by the exegetical narrations. Therefore, in interpreting Qur’ān, they have referred to narrations to express these Buṭūn. In their commentaries on some of the Qur’ānic verses, the contemporary Shiite commentators have referred to the Buṭūn of the verses based on the available narrations and have mentioned different types of Buṭūn and Ta'wīls (Hermeneutic Interpretation). There were some fundamental and practical disagreements among commentators about these narrations as well. This study investigates the Baṭn theory in Tafsīr al-Mīzān with regard to Tafsīr al-Furqān.
The Effectiveness of Creative Products and Entrepreneurship Learning and Teaching Factory to Prepare for Job Creator in the Industrial Revolution Era 4.0
Authors: Dhani Rizki Kurnia , Dhani Rizki Kurnia , Kristiani Kristiani
Published: August 2021

Indonesia has now entered the era of the Industrial Revolution 4.0 that impacts vocational schools which are considered the highest contributor to unemployment in Indonesia. Therefore, the government established a revitalization program in vocational schools by learning about Creative Products and Entrepreneurship as well as Teaching Factories to produce competitive human resources who are ready to become job creators. This study aimed at portraying the effectiveness of Creative Products and Entrepreneurship Learning and teaching factories to prepare for job creators in the Industrial Revolution Era 4.0. The study was conducted by employing a descriptive qualitative method by utilizing the Nvivo 11 software to classify and display the results in the form of diagrams, graphs, and models. The results revealed that the implementation of the Creative Products and Entrepreneurship, as well as the Teaching Factories, has not been effectively transforming vocational students into job creators. There were some encountered factors contributing to this phenomenon; time management, teachers’ competence, students’ motivation, and funding. Thus, evaluations are necessary in terms of planning, development, and implementation to cultivate excellent graduates that are ready to create jobs.