Assessment of spraying characteristics of two nasal sprays containing framycetin
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Gribanova S.V. , Yankova V.G. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Gobyzov O.A. ,   S.S.Kutateladze Institute of Thermophysics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation, Ryabov M.N. ,   S.S.Kutateladze Institute of Thermophysics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation, Karpova A.S. ,   Institute of Pharmaceutical Technologies, Moscow, Russian Federation, Kedik S.A. ,   Russian Technological University, Moscow, Russian Federation, Udyanskaya I.L. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Grigorieva V.Yu. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Krasnyuk (Jr) I.I. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Slonskaya T.K. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Zhukova A.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: July 2022

Objective. To compare spraying characteristics of two nasal sprays containing framycetin – Isofra and Tramicent Materials and methods. We used a silicone model of the nasal cavity (Koken Co. Ltd., Tokyo, Japan) to assess dose distribution of the drug inside the nose. Shadow photography was applied to analyze dynamic characteristics of spraying and the dispersed composition of spray particles. Results. Using a silicone model, we evaluated the dose distribution of the spray inside the nasal cavity. We compared dose distribution of two nasal sprays containing framycetin (Isofra and Tramicent) with full and half-full bottles. Shadow photography was applied to evaluate dynamic characteristics of these sprays, including total duration of spraying, duration of its individual phases, spraying angle, as well as dispersion characteristics, such as average particle size and particle size distributions. Conclusion. The experiments with a silicone nose model demonstrated that Isofra ensured a larger distribution area inside the nasal cavity compared to Terramycin, which suggests a better coverage of the nasal mucosa with Isofra. Comparison of dynamic spraying characteristics (including duration of spraying phases, spraying angle, and shape of the cone) between Isofra and Tramicent using shadow photography showed that Isofra ensured a more homogenous spraying coverage with fine particles. Comparison of the dispersion composition of the two sprays showed that most of the Isofra dose was sprayed with smaller drops than Tramicent, which indicates a better dispersion of Isofra. Our findings suggest that Isofra ensured high quality spraying and effective delivery of the medicine into the nasal cavity. Key words: framycetin, spray, silicone nose model, shadow photography, spray characteristics