bluuebunny/crossref_metadata_2025 huggingface dataset:
Gauge symmetry breaking with fluxes and natural Standard Model structure from exceptional GUTs in F-theory
Authors: Li Shing Yan , Taylor Washington
Published: November 2022

Abstract

We give a general description of gauge symmetry breaking using vertical and remainder fluxes in 4D F-theory models. The fluxes can break a geometric gauge group to a smaller group and induce chiral matter, even when the larger group admits no chiral matter representations. We focus specifically on applications to realizations of the Standard Model gauge group and chiral matter spectrum through breaking of rigid exceptional gauge groups E7, E6, which are ubiquitous in the 4D F-theory landscape. Supplemented by an intermediate SU(5) group, these large classes of models give natural constructions of Standard Model-like theories with small numbers of generations of matter in F-theory.
T-odd leading-twist quark TMDs at small x
Authors: Kovchegov Yuri V. , Santiago M. Gabriel
Published: November 2022

Abstract

We study the small-x asymptotics of the flavor non-singlet T-odd leading-twist quark transverse momentum dependent parton distributions (TMDs), the Sivers and Boer-Mulders functions. While the leading eikonal small-x asymptotics of the quark Sivers function is given by the spin-dependent odderon [1, 2], we are interested in revisiting the sub-eikonal correction considered by us earlier in [3]. We first simplify the expressions for both TMDs at small Bjorken x and then construct small-x evolution equations for the resulting operators in the large-Nc limit, with Nc the number of quark colors. For both TMDs, the evolution equations resum all powers of the double-logarithmic parameter αs ln2(1/x), where αs is the strong coupling constant, which is assumed to be small. Solving these evolution equations numerically (for the Sivers function) and analytically (for the Boer-Mulders function) we arrive at the following leading small-x asymptotics of these TMDs at large Nc:$$ {\displaystyle \begin{array}{l}{f}_{1T}^{\perp NS}\left(x\ll 1,{k}_T^2\right)={C}_O\left(x,{k}_T^2\right)\frac{1}{x}+{C}_1\left(x,{k}_T^2\right){\left(\frac{1}{x}\right)}^{3.4\sqrt{\frac{\alpha_s{N}_c}{4\pi }}}\\ {}{h}_1^{\perp \textrm{NS}}\left(x\ll 1,{k}_T^2\right)=C\left(x,{k}_T^2\right){\left(\frac{1}{x}\right)}^{-1}.\end{array}} $$

f

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T

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x
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1

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=

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O

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+

C
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x

k
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2

1
x

3.4

α
s

N
c

4
π

h
1

⊥
NS

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k
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2

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C

x

k
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x

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1

.

The functions CO(x,$$ {k}_T^2 $$

k
T
2

), C1(x,$$ {k}_T^2 $$

k
T
2

), and C(x,$$ {k}_T^2 $$

k
T
2

) can be readily obtained in our formalism: they are mildly x-dependent and do not strongly affect the power-of-x asymptotics shown above. The function CO, along with the 1/x factor, arises from the odderon exchange. For the sub-eikonal contribution to the quark Sivers function (the term with C1), our result shown above supersedes the one obtained in [3] due to the new contributions identified recently in [4].
The non-apoptotic function of Caspase-8 in negatively regulating the CDK9-mediated Ser2 phosphorylation of RNA polymerase II in cervical cancer
Authors: Mandal Ranadip , Raab Monika , Rödel Franz , Krämer Andrea , Kostova Izabela , Peña-Llopis Samuel , Medici Gioele , Häupl Björn , Oellerich Thomas , Gasimli Khayal , Sanhaji Mourad , Becker Sven , Strebhardt Klaus
Published: November 2022

Cervical cancer is the fourth most frequently diagnosed and fatal gynecological cancer. 15–61% of all cases metastasize and develop chemoresistance, reducing the 5-year survival of cervical cancer patients to as low as 17%. Therefore, unraveling the mechanisms contributing to metastasis is critical in developing better-targeted therapies against it. Here, we have identified a novel mechanism where nuclear Caspase-8 directly interacts with and inhibits the activity of CDK9, thereby modulating RNAPII-mediated global transcription, including those of cell-migration- and cell-invasion-associated genes. Crucially, low Caspase-8 expression in cervical cancer patients leads to poor prognosis, higher CDK9 phosphorylation at Thr186, and increased RNAPII activity in cervical cancer cell lines and patient biopsies. Caspase-8 knock-out cells were also more resistant to the small-molecule CDK9 inhibitor BAY1251152 in both 2D- and 3D-culture conditions. Combining BAY1251152 with Cisplatin synergistically overcame chemoresistance of Caspase-8-deficient cervical cancer cells. Therefore, Caspase-8 expression could be a marker in chemoresistant cervical tumors, suggesting CDK9 inhibitor treatment for their sensitization to Cisplatin-based chemotherapy.
Meromorphic Continuation of Weighted Zeta Functions on Open Hyperbolic Systems
Authors: Schütte Philipp , Weich Tobias , Barkhofen Sonja
Published: November 2022

In this article we prove meromorphic continuation of weighted zeta functions $$Z_f$$

Z
f

in the framework of open hyperbolic systems by using the meromorphically continued restricted resolvent of Dyatlov and Guillarmou (Ann Henri Poincaré 17(11):3089–3146, 2016). We obtain a residue formula proving equality between residues of $$Z_f$$

Z
f

and invariant Ruelle distributions. We combine this equality with results of Guillarmou et al. (Ann Henri Lebesgue 4:81–119, 2021) in order to relate the residues to Patterson–Sullivan distributions. Finally we provide proof-of-principle results concerning the numerical calculation of invariant Ruelle distributions for 3-disc scattering systems.
First trait-based characterization of Arctic ice meiofauna taxa
Authors: Patrohay Evan , Gradinger Rolf , Marquardt Miriam , Bluhm Bodil A.
Published: November 2022

Trait-based approaches connect the traits of species to ecosystem functions to estimate the functional diversity of communities and how they may respond to environmental change. For the first time, we compiled a traits matrix across 11 traits for 28 species of Arctic ice meiofauna, including Copepoda (Subclass), Nematoda (Phylum), Acoela (Order), Rotifera (Phylum), and Cnidaria (Phylum). Over 50 years of pan-Arctic literature were manually reviewed, and trait categories were assigned to enable future trait–function connections within the threatened ice-associated ecosystem. Approximately two-thirds of the traits data were found at the genus or species level, ranging from 44% for Nematoda to 100% for Cnidaria. Ice meiofauna were shown to possess advantageous adaptations to the brine channel network within sea ice, including a majority with small body widths < 200 μm, high body flexibility, and high temperature and salinity tolerance. Diets were found to be diverse outside of the algal bloom season, with most organisms transitioning to ciliate-, omnivore-, or detritus-based diets. Eight species of the studied taxa have only been recorded within sea ice, while the rest are found in a mixture of sympagic–pelagic–benthic habitats. Twelve of the ice meiofauna species have been found with all life stages present in sea ice. Body width, temperature tolerance, and salinity tolerance were identified as traits with the largest research gaps and suffered from low-resolution taxonomic data. Overall, the compiled data show the degree to which ice meiofauna are adapted to spending all or portions of their lives within the ice.
Automated segmentation of craniopharyngioma on MR images using U-Net-based deep convolutional neural network
Authors: Chen Chaoyue , Zhang Ting , Teng Yuen , Yu Yijie , Shu Xin , Zhang Lei , Zhao Fumin , Xu Jianguo
Published: November 2022

Objectives

To develop a U-Net-based deep learning model for automated segmentation of craniopharyngioma.

Methods

A total number of 264 patients diagnosed with craniopharyngiomas were included in this research. Pre-treatment MRIs were collected, annotated, and used as ground truth to learn and evaluate the deep learning model. Thirty-eight patients from another institution were used for independently external testing. The proposed segmentation model was constructed based on a U-Net architecture. Dice similarity coefficients (DSCs), Hausdorff distance of 95% percentile (95HD), Jaccard value, true positive rate (TPR), and false positive rate (FPR) of each case were calculated. One-way ANOVA analysis was used to investigate if the model performance was associated with the radiological characteristics of tumors.

Results

The proposed model showed a good performance in segmentation with average DSCs of 0.840, Jaccard of 0.734, TPR of 0.820, FPR of 0.000, and 95HD of 3.669 mm. It performed feasibly in the independent external test set, with average DSCs of 0.816, Jaccard of 0.704, TPR of 0.765, FPR of 0.000, and 95HD of 4.201 mm. Also, one-way ANOVA suggested the performance was not statistically associated with radiological characteristics, including predominantly composition (p = 0.370), lobulated shape (p = 0.353), compressed or enclosed ICA (p = 0.809), and cavernous sinus invasion (p = 0.283).

Conclusions

The proposed deep learning model shows promising results for the automated segmentation of craniopharyngioma.

Key Points

• The segmentation model based on U-Net showed good performance in segmentation of craniopharyngioma.

• The proposed model showed good performance regardless of the radiological characteristics of craniopharyngioma.

• The model achieved feasibility in the independent external dataset obtained from another center.
Fluocinolone acetonide 0.19-mg implant for the treatment of noninfectious uveitis with involvement of the posterior segment: a real-world study
Authors: Buhl Lara , Thurau Stephan , Kern Christoph
Published: November 2022

Purpose

To evaluate the effectiveness of 0.19-mg fluocinolone acetonide implant (FAi) for preventing inflammatory relapses in noninfectious uveitis with posterior segment involvement in standard clinical practice. Further, to assess the value of remission induction therapy with intraocular and periorbital administered high-dose corticosteroids before FAi.

Methods

A retrospective cohort study in a tertiary referral center specialized in uveitis management. The primary study outcomes were the best-corrected visual acuity (BVCA) and central retinal thickness (CRT) within a 12-month observation period. The secondary outcomes were intraocular pressure (IOP) and intraocular inflammation. The main safety measures were IOP increase and cataract formation.

Results

In total, 76 eyes of 57 patients received FAi. Locally administered high-dose corticosteroids were applied in 68.4% of all eyes before FAi. BCVA remained stable within the 12-month observation period (63.21 vs. 62.95, difference 0.26 letters; 95% CI: − 6.31 to 6.84; p > 0.9). Significant CRT reduction upon FAi was sustained after 12 months (362.7 vs. 309.1 μm, difference 53.57 μm; 95% CI: 1.55 to 105.6; p = 0.04). Intraocular inflammation was reduced until 9 months of follow-up (0.82 vs. 0.3, difference 0.53; 95% CI: 0.11 to 0.95; p = 0.007). A mean IOP increase (13.68 vs. 15.6; difference − 1.92; 95% CI: − 3.85 to 0.004; p = 0.0507) and cataract development (20% of all phakic eyes) were noted.

Conclusion

We observed similar levels of FAi effectiveness for the treatment of noninfectious uveitis in standard clinical practice compared to previous randomized clinical trials. Moreover, remission induction therapy before FAi can benefit patients with increased baseline uveitis activity.
Incidental FOXL2 mutated adult granulosa cell tumour of the ovary with thecoma-like foci
Authors: Fischer Anne Kristin , Schömig-Markiefka Birgid , Heydt Carina , Ratiu Dominik , Mallmann Peter , Meinel Jörn , Büttner Reinhard , Schmidt Dietmar , Quaas Alexander
Published: November 2022

We report on the incidental finding of a FOXL2 mutated adult granulosa cell tumour of the ovary with thecoma-like foci, a rare entity recently described by Jennifer N. Stall and Robert H. Young in a series of sixteen cases in 2019, displaying features differing from conventional adult granulosa cell tumour. Our aim is to specify the morphologic and molecular particularities of this presumably underrecognized finding, with a short presentation of the typical clinical context. Awareness of this rare and challenging neoplasm with indeterminate clinical course is crucial in routine diagnostics.
Viremia as a predictor of absence of serious bacterial infection in children with fever without source
Authors: Galetto-Lacour Annick , Cordey Samuel , Papis Sebastien , Mardegan Chiara , Luterbacher Fanny , Combescure Christophe , Lacroix Laurence , Gervaix Alain , Kaiser Laurent , Posfay-Barbe Klara M. , L’Huillier Arnaud G.
Published: November 2022

Most children with fever without source (FWS) require diagnostic laboratory tests to exclude a serious bacterial infection (SBI), often followed by admission and empirical antibiotics. As febrile children with a viral infection are less likely to have a SBI, identifying patients with systemic viral infection could contribute to exclude SBI. We evaluated whether the presence of virus in the blood could be used as a biomarker to rule out SBI. Children < 3 years old with FWS were prospectively enrolled and had real-time (reverse-transcription) PCR performed on the blood for adenovirus, enterovirus, parechovirus, and HHV6. 20/135 patients had SBI, and in 47/135, at least one virus was detected in the blood. Viremia had a higher sensitivity and negative predictive value (90% and 96%) to rule out SBI compared to CRP (65% and 93%) and PCT (55% and 90%). The odds ratio (OR) for the presence of SBI among non-viremic patients was 5.8 (p = 0.0225), compared to 5.5 for CRP ≥ 40 mg/l (p = 0.0009) and 3.7 for PCT ≥ 0.5 ng/mL (0.0093). This remained significant after adjusting for CRP and PCT (OR 5.6 and 5.9, respectively; p = 0.03 for both). Area under the ROC curve for CRP and PCT were 0.754 and 0.779, respectively, but increased to 0.803 and 0.832, respectively, when combined with viremia.

Conclusion: The presence of viremia had a better performance than commonly used biomarkers to rule-out SBI and could potentially be used in conjunction with CRP and/or PCT in the evaluation of children with FWS. Larger studies should evaluate the role of point-of-care testing of viruses by (revere-transcription) PCR in the plasma in management algorithms of children with FWS.

What is Known:• Most children with FWS have a viral infection, but up to 15% have a SBI; most require laboratory tests, and many admission and empirical antibiotics.• Children with a viral infection are less likely to have a SBI.

What is New:• Children with a systemic viral infection are less likely to have an SBI.• Viremia is a better predictor of absence of SBI than commonly used biomarkers and could potentially be used in conjunction with CRP and/or PCT in the evaluation of children with FWS.
Resilience in cancer patients and how it correlates with demographics, psychological factors, and lifestyle
Authors: Festerling Lara , Buentzel J. , Fischer von Weikersthal L. , Junghans C. , Zomorodbakhsch B. , Stoll C. , Prott F.-J. , Fuxius S. , Micke O. , Richter A. , Sallmann D. , Huebner J. , Hoppe Catalina
Published: November 2022

Background

Being diagnosed with cancer is challenging. Many patients wish to be actively involved in treatment and contribute to therapy, but the patients’ coping abilities and desire for involvement differ. The individual level of resilience seems to play a major role. Our study aims to learn more about the associations of resilience and factors as demographics and psychological factors.

Methods

This multicentric cross-sectional study was conducted in ten oncological centers in Germany in summer 2021. The questionnaire collected information on demographics, resilience, self-efficacy, general satisfaction with life, and sense of coherence. Considered lifestyle-aspects were diet and physical activity. 416 patients were included in the analyses.

Results

A moderate mean resilience score was achieved (M = 69). Significant correlations in demographics were found for resilience and education (r = 0.146, p = 0.003), income (r = 0.205, p = 0.001), and time since receiving diagnosis (r = − 0.115, p = 0.021). Resilience and self-efficacy correlated on a high level (r = 0.595, p < 0.001), resilience and sense of coherence, and resilience and general satisfaction with life in a moderate way (r = 0.339, p < 0.001; r = 0.461, p = 0.001).

Conclusions

Resilience portrays an important aspect in cancer treatment. Detecting patients at risk, stabilizing, or improving resilience are important to focus on and strengthen them accordingly. Possible negatively influencing factors (e.g., low self-efficacy) need to be considered. Factors affecting resilience but difficult to influence, as educational background, should be screened for. Also, the combination of low resilience and low income seems to describe a vulnerable patient group.
Impact of shifting from laparoscopic to robotic surgery during 600 minimally invasive pancreatic and liver resections
Authors: Emmen Anouk. M. L. H. , Görgec B. , Zwart M. J. W. , Daams F. , Erdmann J. , Festen S. , Gouma D. J. , van Gulik T. M. , van Hilst J. , Kazemier G. , Lof S. , Sussenbach S. I. , Tanis P. J. , Zonderhuis B. M. , Busch O. R. , Swijnenburg R. J. , Besselink M. G. ,   for HPB-Amsterdam
Published: November 2022

Background

Many centers worldwide are shifting from laparoscopic to robotic minimally invasive hepato-pancreato-biliary resections (MIS-HPB) but large single center series assessing this process are lacking. We hypothesized that the introduction of robot-assisted surgery was safe and feasible in a high-volume center.

Methods

Single center, post-hoc assessment of prospectively collected data including all consecutive MIS-HPB resections (January 2010–February 2022). As of December 2018, all MIS pancreatoduodenectomy and liver resections were robot-assisted. All surgeons had participated in dedicated training programs for laparoscopic and robotic MIS-HPB. Primary outcomes were in-hospital/30-day mortality and Clavien-Dindo ≥ 3 complications.

Results

Among 1875 pancreatic and liver resections, 600 (32%) were MIS-HPB resections. The overall rate of conversion was 4.3%, Clavien-Dindo ≥ 3 complications 25.7%, and in-hospital/30-day mortality 1.8% (n = 11). When comparing the period before and after the introduction of robotic MIS-HPB (Dec 2018), the overall use of MIS-HPB increased from 25.3 to 43.8% (P < 0.001) and blood loss decreased from 250 ml [IQR 100–500] to 150 ml [IQR 50–300] (P < 0.001). The 291 MIS pancreatic resections included 163 MIS pancreatoduodenectomies (52 laparoscopic, 111 robotic) with 4.3% conversion rate. The implementation of robotic pancreatoduodenectomy was associated with reduced operation time (450 vs 361 min; P < 0.001), reduced blood loss (350 vs 200 ml; P < 0.001), and a decreased rate of delayed gastric emptying (28.8% vs 9.9%; P = 0.009). The 309 MIS liver resections included 198 laparoscopic and 111 robotic procedures with a 3.6% conversion rate. The implementation of robotic liver resection was associated with less overall complications (24.7% vs 10.8%; P = 0.003) and shorter hospital stay (4 vs 3 days; P < 0.001).

Conclusion

The introduction of robotic surgery was associated with greater implementation of MIS-HPB in up to nearly half of all pancreatic and liver resections. Although mortality and major morbidity were not affected, robotic surgery was associated with improvements in some selected outcomes. Ultimately, randomized studies and high-quality registries should determine its added value.

Graphical Abstract
Ecological status of Lake Nasser Khors, Egypt, before operating the Grand Ethiopian Renaissance Dam
Authors: Abdel-Aal Eman I. , Haroon Amany M. , Ibrahim Shaimaa M. , Abd El-Aziz Ghada S. , Sabae Soaad A. , Gaber Khadiga M. , Goher Mohamed E.
Published: November 2022

Lake Nasser is an artificial reservoir that represents the national freshwater reserve of Egypt and has a number of khors (side extensions) along its eastern and western banks. These khors covered approximately 79% of the lake’s total surface area and have an important effect on water quality and fish production in the lake. This study aimed to monitor and assess the water quality, distribution, and structure of the biotic community, including phytoplankton, zooplankton, macrophytes, epiphytes, and macrobenthos in two main khors (Tushka West and Dahmeit) during postflood and preflood periods. There was urgency associated with the study, as it was the last opportunity before the storing of the water behind the Grand Ethiopian Renaissance Dam (GERD), which had begun to fill in July 2020. Although the study confirmed that the water quality of Lake Nasser was good, it is classified as a eutrophic lake (depending on the levels of Chlorophyll-a and nutrients). This study found that pH, NO2, SiO4, NH4, PO4, and temperature were the factors with the greatest effect on the biota community, especially in Dahmeit Khor. In contrast to the phytoplankton and macrobenthos, the highest total density of zooplankton and epiphytic microalgae were detected during the postflood period. This study could be useful in monitoring possible changes in the Lake Nasser environment after the complete filling of the GERD reservoir.
Understanding the Unique Barriers and Facilitators that Affect Men’s Initiation and Retention in HIV Care: A Qualitative Study to Inform Interventions for Men Across the Treatment Cascade in Malawi
Authors: Coursey Kate , Phiri Khumbo , Choko Augustine T. , Kalande Pericles , Chamberlin Stephanie , Hubbard Julie , Thorp Marguerite , Hoffman Risa , Coates Thomas J. , Dovel Kathryn
Published: November 2022

Men in sub-Saharan Africa are underrepresented in antiretroviral therapy (ART) programs. Our secondary analysis of 40 in-depth interviews with Malawian men living with HIV examined barriers and facilitators for ART initiation versus retention. Interviewees included men who never initiated or initiated ART late (initiation respondents, n = 19); and men who initiated ART but were late for an appointment (retention respondents, n = 21). Transcribed interviews were coded using deductive and inductive coding techniques and analyzed using constant comparison methods. Long wait times, frequent facility visits, and insufficient in-clinic privacy were barriers for initiation and retention. Poor knowledge of ART was primarily a barrier for initiation; unexpected travel was a barrier for retention. Key facilitators for initiation and retention included previous positive experiences with health facilities. Having examples of successful men using ART primarily facilitated initiation; support from spouses and male peers facilitated retention. Results may inform interventions to increase men’s engagement in ART services.
Trait Aggression is Reflected by a Lower Temporal Stability of EEG Resting Networks
Authors: Kleinert Tobias , Nash Kyle
Published: November 2022

Trait aggression can lead to catastrophic consequences for individuals and society. However, it remains unclear how aggressive people differ from others regarding basic, task-independent brain characteristics. We used EEG microstate analysis to investigate how the temporal organization of neural resting networks might help explain inter-individual differences in aggression. Microstates represent whole-brain networks, which are stable for short timeframes (40–120 ms) before quickly transitioning into other microstate types. Recent research demonstrates that the general temporal stability of microstates across types predicts higher levels of self-control and inhibitory control, and lower levels of risk-taking preferences. Given that these outcomes are inversely related to aggression, we investigated whether microstate stability at rest would predict lower levels of trait aggression. As males show higher levels of aggression than females, and males and females express aggression differently, we also tested for possible gender-differences. As hypothesized, people with higher levels of trait aggression showed lower microstate stability. This effect was moderated by gender, with men showing stronger associations compared to women. These findings support the notion that temporal dynamics of sub-second resting networks predict complex human traits. Furthermore, they provide initial indications of gender-differences in the functional significance of EEG microstates.
Substrate type induces plastic responses in the craniofacial morphology of a winnowing cichlid
Authors: Gilbert Michelle C. , Piggott Sofia N. , Albertson R. Craig
Published: November 2022

Understanding how local populations respond to specific changes in the environment can help us better predict how populations respond to such change. With this topic in mind, we followed up on a previous study by exploring the capabilities of a Geophagini cichlid, known for its unique feeding strategy, to mount a plastic response. We exposedSatanoperca daemon, a winnowing cichlid, to three different substrate types, two of which encouraged winnowing behaviors and a third that prevented winnowing entirely. Using geometric morphometrics, we quantified aspects of craniofacial anatomy to test for morphological differences between the treatments and to test for the integration of different traits across the head. We found significant differences across our experimental populations in both shape and disparity. We report evidence in support of wide-spread integration across craniofacial traits. A notable exception to this pattern was the epibranchial lobe, a structure unique to the Geophagini, which exhibited more modular variation. Since anthropogenic alterations such as the damming of rivers can impact substrate type, these data offer insights into how Geophagini cichlids may respond to environmental change. In addition, this work further illuminates the functional morphology of winnowing foraging behaviors.
The emergence of human metapneumovirus G gene duplication in hospitalized patients with respiratory tract infection, India, 2016–2018
Authors: Parida Preetiparna , N Sudheesh , E.R Sanjay , Jagadesh Anitha , Marate Srilatha , Govindakaranavar Arunkumar
Published: November 2022

Background

Human metapneumovirus (HMPV) belongs to the family Pneumoviridae. It is one of the emerging respiratory viruses causing both upper and lower respiratory tract illnesses. HMPV has two genotypes: A and B. These genotypes are classified into lineage A1, A2, B1 and B2. Lineage-A2 is further classified as A2a, A2b and A2c. Similarly, B2 is classified as B2a and B2b. Studies have shown the circulation of A2b, B1 and B2 lineages in India. However, a limited amount of data is available on the current circulating genotypes of HMPV in India.

Methods

Throat swab samples positive for HMPV by real-time RT- PCR, archived at Manipal Institute of Virology as a part of a hospital-based acute febrile illness surveillance study, was used from April 2016 to August 2018 by purposive sampling method. We performed the conventional reverse transcriptase-polymerase chain reaction for twenty samples targeting the G gene and then subjected them to sequencing. Phylogenetic analysis was done using MEGA X software by the Maximum Likelihood method.

Results

All the twenty sequences belonged to the A2c subgroup. Phylogenetic analysis showed that strains from the study have genetic relation with circulating strains in Japan, China and Croatia. Seven out of the twenty sequences showed 180-nucleotide duplication and eleven sequences showed 111-nucleotide duplication. Two sequences did not show any duplications.

Conclusion

In the current study, we report that A2c is the sub-lineage in India from April 2016 to August 2018. This study is the first retrospective study reporting the circulation of the A2c sub-lineage among adults in India with 180- and 111-nucleotide duplications in the G gene of human metapneumovirus.
The management of congenital adrenal hyperplasia during preconception, pregnancy, and postpartum
Authors: Maher Jacqueline Yano , Gomez-Lobo Veronica , Merke Deborah P.
Published: November 2022

Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders of steroidogenesis of the adrenal cortex, most commonly due to 21-hydroxylase deficiency caused by mutations in the CYP21A2 gene. Although women with CAH have decreased fecundity, they are able to conceive; thus, if pregnancy is not desired, contraception options should be offered. If fertility is desired, women with classic CAH should first optimize glucocorticoid treatment, followed by ovulation induction medications and gonadotropins if needed. Due to the possible pregnancy complications and implications on the offspring, preconception genetic testing and counseling with a high-risk obstetrics specialist is recommended. For couples trying to avoid having a child with CAH, care with a reproductive endocrinology and infertility specialist to utilize in vitro fertilization can be offered, with or without preimplantation genetic testing for monogenic disorders. Prenatal screening and diagnosis options during pregnancy include maternal serum cell free-DNA for sex of the baby, and chorionic villus sampling and amniocentesis for diagnosis of CAH. Pregnant women with classic CAH need glucocorticoids to be adjusted during the pregnancy, at the time of delivery, and postpartum, and should be monitored for adrenal crisis. Maternal and fetal risks may include chorioamnionitis, maternal hypertension, gestational diabetes, cesarean section, and small for gestational age infants. This review on CAH due to 21-hydroxylase deficiency highlights reproductive health including genetic transmission, contraception options, glucocorticoid management, fertility treatments, as well as testing, antenatal monitoring, and management during pregnancy, delivery, and postpartum.
An updated insight on testicular hemodynamics: Environmental, physiological, and technical perspectives in farm and companion animals
Authors: Samir Haney , ElSayed Mohamed I. , Radwan Faten , Hedia Mohamed , Hendawy Hanan , Hendawy Amin Omar , Elbadawy Mohamed , Watanabe Gen
Published: November 2022

In all organs, control of blood flow is important but might be particularly critical for testicular functions. This is because of the very low oxygen concentration and high metabolic rate of the seminiferous tubules, the physiological temperature of the testis, and its location outside the abdominal cavity. Many factors affect the characteristics of TBF in farm and companion animals, such as environment (thermal and seasonal effects) and physiological (species, breeds, age, body weight, and sexual maturity). Thermal environment stress has detrimental effects on spermatogenesis and consequently has more serious impacts on both human and animal fertility. Numerous studies have been performed to assess TBF in different animal species including bulls, rams, bucks, alpacas, stallions, and dogs with varied results. Hence, assessment of TBF by Doppler ultrasonography is of great importance to estimate the effect of high environment temperature on testicular functions. Also, differences observed in the TBF may result from different technical aspects such as the identification of the segment of the testicular artery to be examined. In the current review, we focused on the imperative roles of TBF in various animal species. Besides, we discussed in detail various factors that could affect TBF. These factors can significantly modify the TBF and thus should be considered when establishing reference values in farm animals for better clinical diagnosis. The information provided in this review is valuable for researchers and veterinarians to help them a better understanding of testicular hemodynamics for the proper evaluation of breeding soundness examination in males.
ER-Protein Creld kontrolliert die Bildung von ROS in den Mitochondrien
Authors: Kucharowski Nicole , Bülow Margret H.
Published: November 2022

The endoplasmic reticulum (ER) and mitochondria interact and exchange material in healthy neurons. Mutants for the ER protein Creld show strong, Parkinson’s disease-like locomotion deficits. We found that Creld facilitates phospholipid flux at the ER-mitochondria interface, thereby enabling the formation of hydrogen peroxide at respiratory complex I, which is required for dopaminergic neuron activity.
Mindfulness-Based Pain Management (MBPM) for Chronic Pain: a Randomized Clinical Trial
Authors: Pérez-Fernández José Ignacio , Salaberria Karmele , Ruiz de Ocenda Álvaro
Published: November 2022

Objectives

Chronic
pain affects 1 in 5 Europeans, with a prevalence in Spain of 11%. It is one of the main causes of medical consultation and is associated with high personal, social, and economic costs with diverse psychological repercussions. Several studies have shown the effectiveness of psychological therapies in the treatment of chronic pain, including mindfulness-based therapies. In this regard, mindfulness-based pain management (MBPM) has evidenced significant positive changes in patients with chronic pain, but so far, no RCT study has been conducted. Therefore, the main purpose of this study is to explore the results of the MBPM program with chronic pain patients. Additionally, we will analyze the differential efficacy of the MBPM program on fibromyalgia versus non-fibromyalgia chronic pain patients.

Methods

Ninety patients with chronic pain were randomized to experimental group MBPM (50 patients) and wait-list control group (40 patients) and assessed at pre- and post-treatment in demographic and pain-related variables, psychopathological symptoms, cognitive variables, resilience, and quality of life.

Results

Findings showed moderate to large effects in favor of the experimental group in pain management and acceptance, use of analgesics, psychopathological symptoms, general negative thoughts, self-blame, mental-health-related quality of life, and resilience. Non-fibromyalgia chronic pain patients benefited significantly more than participants with fibromyalgia.

Conclusions

The positive impact of the MBPM program on critical variables related to chronic pain provides evidence of its efficacy, which could be enhanced with the inclusion of complementary therapeutic CBT components to address sleep problems, need for control, and rumination.

Trial Registration

ClinicalTrials.gov (NCT03992612).
Quantifying acid diversion efficiency through NMR tortuosity measurements
Authors: Elsayed Mahmoud , BinGhanim Ahmed , Aljawad Murtada Saleh , El-Husseiny Ammar , Al-Abdrabalnabi Ridha , Mahmoud Mohamed
Published: November 2022

The diversion efficiency measures the acid capacity to change its flow direction to the lower permeability reservoir sections. A good acid diverter creates a tortuous (zigzagged) wormhole within the acidized core sample in a laboratory setup. Here, we studied two different acid diverters compared to the conventional hydrochloric acid (HCl) to investigate their efficiency in changing the wormhole direction inside the rock core. Nuclear magnetic resonance (NMR) can be used to measure the 3D tortuosity of a rock sample; hence, we propose it as a tool to measure acid diversion efficiency because it can be applied in the field and in the laboratory. Two acid systems were utilized: straight 15 wt.% HCl acid and gelled acid consisting of 15 wt.% HCl acid and polyacrylamide polymer (PAM). Four coreflooding experiments were conducted on 1.5 inch-diameter × 3 inch-length Indiana limestone samples, two with straight HCl acid and two with gelled HCl acid at different PAM concentrations. NMR was utilized to measure the T2 distribution of the rock samples and diffusion tortuosity in two orthogonal directions. Also, X-ray computed tomography (CT) of the acidized samples was taken to visualize the wormholes. Results showed that the polymer-based acid-created zigzagged paths, and more acid volume was consumed to create the wormholes using CT. NMR diffusion tortuosity measurements showed that the tortuosity was reduced along the wormhole direction in all experiments. Nevertheless, the gelled acid treatments showed a significant reduction of the tortuosity orthogonal to the main wormhole path. The diversion efficiency of the 50 lbm/ 1000 gal PAM-gelled acid was 35% higher compared to the straight HCl acid. On the contrary, the 30 lbm/ 1000 gal PAM-gelled acid gave only 10% improvement in the diversion. The index could screen quantitatively which diverting acid is more efficient. We introduced a new diversion index based on the NMR diffusion measurements in this study to quantify the diversion capacity of an acid system in carbonate rock.
Sensitivity and specificity of monocyte distribution width (MDW) in detecting patients with infection and sepsis in patients on sepsis pathway in the emergency department
Authors: Cusinato Martina , Sivayoham Narani , Planche Timothy
Published: November 2022

Purpose

Monocyte distribution width (MDW) is a biomarker for the early identification of sepsis. We assessed its accuracy in patients presenting with suspected sepsis in the emergency department (ED).

Methods

This was a single gate, single centre study in consecutive adults (≥ 18 years) admitted to the ED with suspected sepsis and clinical history compatible with infection, between 01 January and 31 December 2020 (n = 2570).

Results

The overall median MDW was 22.0 (IQR 19.3, 25.6). Using Sepsis-3 (qSOFA) to define sepsis, the Area Under Curve (AUC) for a receiver operator characteristic (ROC) relationship was 0.59 (95% CI 0.56, 0.61). Discrimination was similar using other clinical scores, and to that of C-reactive protein. At an MDW cutoff of 20.0, sensitivity was 0.76 (95% CI 0.73, 0.80) and specificity 0.35 (95% CI 0.33, 0.37) for Sepsis-3. MDW showed better performance to discriminate infection, with AUC 0.72 (95% CI 0.69, 0.75). At MDW 20.0, sensitivity for infection was 0.72 (95% CI 0.70, 0.74) and specificity 0.64 (95% CI 0.59, 0.70). A sensitivity analysis excluding coronavirus disease (COVID-19) admissions (n = 552) had no impact on the AUC. MDW distribution at admission was similar for bacteraemia and COVID-19.

Conclusions

In this population of ED admissions with a strong clinical suspicion of sepsis, MDW had a performance to identify sepsis comparable to that of other commonly used biomarkers. In this setting, MDW could be a useful additional marker of infection.
When Minoritized Languages Change Linguistic Theory
Authors: Nevins Andrew
Published: November 2022

For decades, a small set of major world languages have formed the basis of the vast majority of linguistic theory. However, minoritized languages can also provide fascinating contributions to our understanding of the human language faculty. This pioneering book explores the transformative effect minoritized languages have on mainstream linguistic theory, which, with their typically unusual syntactic, morphological and phonological properties, challenge and question frameworks that were developed largely to account for more widely-studied languages. The chapters address the four main pillars of linguistic theory – syntax, semantics, phonology, and morphology – and provide plenty of case studies to show how minoritized language can disrupt assumptions, and lead to modifications of the theory itself. It is illustrated with examples from a range of languages, and is written in an engaging and accessible style, making it essential reading for both students and researchers of theoretical syntax, phonology and morphology, and language policy and politics.
Response regimes in the fluid–structure interaction of wall turbulence over a compliant coating
Authors: Greidanus A.J. , Delfos R. , Picken S.J. , Westerweel J.
Published: November 2022

The interaction between a turbulent boundary layer flow and compliant surfaces is investigated experimentally. Three viscoelastic coatings with different material stiffnesses are used to identify the general surface response to the turbulent flow conditions. For the softest coating, the global force measurements show two obvious regimes of interaction with an indicated transition at

$U_b/C_t\sim 3.5$

, where

$U_b$

is the bulk flow velocity and

$C_t$

is the coating shear velocity. The one-way coupled regime shows friction values comparable to those of the rigid wall, while the two-way coupled regime indicate a significant increase in fluid friction. Within the one-way coupled regime for

$U_b/C_t>1.2$

, the flow measurements show a low level of two-way coupling represented by the change of the velocity profile as well as the increase in the Reynolds stresses in the near-wall region. This is supported by the surface deformation measurements. Initially, the turbulent flow structures induce only an imprint on the coating surface, while a change in surface response occurs when the surface wave propagation velocity

$c_w$

equals the shear wave velocity of the coating

$C_t$

(i.e.

$c_w/C_t\sim 1$

). Above

$U_b/C_t>1.2$

, a growth in wavelength is observed with increasing flow velocity, most probably due to the surface wave formation generated downstream the pressure features of the flow. The surface response is stable and correlates with the high-intensity turbulent pressure fluctuations in the turbulent boundary layer, with a wave propagation velocity

$c_w\sim 0.7\unicode{x2013}0.8$

$U_b$

. Within the two-way coupled regime, additional fluid motions and a downward shift in the logarithmic region of the velocity profile are observed due to substantial surface deformation and confirm the frictional drag increase. Another type of surface response is initiated by phase-lag instability in combination with surface undulations that start to protrude the viscous sublayer, where the propagation velocity of surface wave trains is

$c_w\sim 0.17\unicode{x2013}0.18$

$U_b$

.
Early asymmetric growth of planetary stagnant lids
Authors: Watson Callum , Neufeld Jerome A. , Michaut Chloé
Published: November 2022

Convection within planetary bodies is often modelled using a temperature-dependent rheology which, when cooled from the surface, naturally leads to the formation of a so-called stagnant lid at the cold outer surface. However, for sufficiently large planets the phase diagram describing the partially molten system may depend significantly on pressure in addition to temperature, leading to significant variations in solid fraction. The aggregate rheology may therefore exhibit significant dependence on both the temperature and pressure, and hence may exhibit marked dependence on depth in addition to the dependence on the thermal structure due to convection. Here, we consider the growth and stability of a planetary stagnant lid. We first characterise the effect of a pressure- and temperature-dependent rheology on the evolution of a symmetric, planetary stagnant lid. This analysis further suggests that the pressure dependence of the rheology may lead to an instability of the growing stagnant lid which, importantly, may lead to asymmetric lid growth. We find that the most unstable mode is at the longest wavelengths, and discuss the implications for stagnant-lid convection and the growth of asymmetric surfaces of planetary bodies. In particular, we discuss the possibility that this instability has implications for the formation of the crustal dichotomy found on the Moon.
Slender body theories for rotating filaments
Authors: Maxian Ondrej , Donev Aleksandar
Published: November 2022

Slender fibres are ubiquitous in biology, physics and engineering, with prominent examples including bacterial flagella and cytoskeletal fibres. In this setting, slender body theories (SBTs), which give the resistance on the fibre asymptotically in its slenderness

$\epsilon$

, are useful tools for both analysis and computations. However, a difficulty arises when accounting for twist and cross-sectional rotation: because the angular velocity of a filament can vary depending on the order of magnitude of the applied torque, asymptotic theories must give accurate results for rotational dynamics over a range of angular velocities. In this paper, we first survey the challenges in applying existing SBTs, which are based on either singularity or full boundary integral representations, to rotating filaments, showing in particular that they fail to consistently treat rotation–translation coupling in curved filaments. We then provide an alternative approach which approximates the three-dimensional dynamics via a one-dimensional line integral of Rotne–Prager–Yamakawa regularized singularities. While unable to accurately resolve the flow field near the filament, this approach gives a grand mobility with symmetric rotation–translation and translation–rotation coupling, making it applicable to a broad range of angular velocities. To restore fidelity to the three-dimensional filament geometry, we use our regularized singularity model to inform a simple empirical equation which relates the mean force and torque along the filament centreline to the translational and rotational velocity of the cross-section. The single unknown coefficient in the model is estimated numerically from three-dimensional boundary integral calculations on a rotating, curved filament.
Supreme Court Impacts in Public Health Law: 2021-2022
Authors: Hodge James G. , White Erica N. , Freed Rebecca , Wells Nora
Published: November 2022

In a dynamic term of the United States Supreme Court in 2021-2022 a series of critical cases raise manifold changes and impacts on individual and communal health through 10 key areas ranging from abortions to vaccinations.
INTRODUCTION
Authors: Levine Admiral Rachel L.
Published: November 2022

I am pleased to introduce this Symposium Edition of The Journal of Law, Medicine & Ethics, which covers a wide variety of issues central to transgender health equity, including Dr. Jamison Green’s recent history of the impact of health policy on transgender communities, Dr. M. Killian Kinney, Ms. Taylor Pearson, and Prof. Julie Ralston Aoki’s transgender equity tool for legal policy analysis, and Prof. Elizabeth Kukura’s analysis of issues facing transgender, non-binary, and gender expansive people during pregnancy and childbirth.
Reconceiving Reproductive Health Systems: Caring for Trans, Nonbinary, and Gender-Expansive People During Pregnancy and Childbirth
Authors: Kukura Elizabeth
Published: November 2022

This article examines the barriers to quality health care for transgender, nonbinary, and gender-expansive people (TGE) who become pregnant and give birth, identifying three central themes that emerge from the literature. These insights suggest that significant reform will be necessary to ensure access to safe, appropriate, gender-affirming care for childbearing TGE people. After illustrating the need for systemic changes that untether rigid gender norms from the provision of perinatal care, the article proposes that the Midwives Model of Care offers a set of values and clinical practices that are well-suited to meet the needs of many TGE patients during pregnancy and childbirth and which should be incorporated into the healthcare system more broadly.
Improving “Life Chances”: Surveying the Anti-Transgender Backlash, and Offering a Transgender Equity Impact Assessment Tool for Policy Analysis
Authors: Kinney M. Killian , Pearson Taylor E. , Ralston Aoki Julie
Published: November 2022

Transgender inclusion within policy is critical yet often missing. We propose a policy tool to assesses human rights, access to resources and opportunities, language, and implications for transgender and nonbinary individuals. Acknowledging trans communities as standard policy practice can serve as an essential practice to shift dialogue and norms.
State Laws for Autonomous Vehicle Safety, Equity, and Insurance
Authors: Ehsani Johnathon P. , Hellinger Andrew , Stephens Daniel K. , Shin Mi Ran , Michael Jeffrey , McCourt Alexander , Vernick Jon
Published: November 2022

This article reviews existing state laws related to autonomous vehicle (AV) safety, equity, and automobile insurance. Thirty states were identified with relevant legislation. Of these, most states had one or two relevant laws in place. Many of these laws were related to safety and insurance requirements. Data are needed to evaluate the effectiveness of these laws in order to guide further policy development.