bluuebunny/crossref_metadata_2025 huggingface dataset:
Associations between oxidative balance score and chronic kidney disease events in type 2 diabetes mellitus patients: a cross‑sectional study
Authors: Ding Yunhe , Liu Bing , Feng Zhen , Liu Xuehua , Wei Zimeng , Fan Lixia
Published: January 2025

The Oxidative Balance Score (OBS) serves as a comprehensive metric that amalgamates 17 dietary and lifestyle elements to evaluate antioxidant status. Thi research aims to investigate the association between the OBS and the prevalence of chronic kidney disease (CKD) in individuals diagnosed with type 2 diabetes mellitus (T2DM). This cross-sectional study included data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2018. CKD was determined using the albumin-to-creatinine ratio(ACR)and estimated glomerular filtration rate (eGFR). Patients were grouped into low, moderate, and high-risk categories based on their risk levels. The OBS variable was transformed from a continuous format into quartiles for subsequent analysis. Weighted multivariable logistic regression and restricted cubic spline models were employed to examine the relationship. Subgroup analyses and interaction tests assessed the findings' robustness. The results indicated a negative correlation between OBS and CKD risk. Individuals in higher OBS quartiles exhibited a decreased prevalence of CKD (OR 0.69, 95% CI: 0.57–0.85, P = 0.0003). A notable correlation was identified between OBS and CKD prevalence among the low-risk and moderate-risk groups. The subgroup analysis results were stable, and no significant interactions were detected among the subgroups. Increased OBS levels were correlated with a decreased risk of CKD. Improving antioxidant capacity through dietary and lifestyle modifications to enhance OBS may serve as an effective strategy for CKD prevention.
Autistic traits modulate social attention: Evidence for cultural generalizability from a community sample in India
Authors: Nair Krishna S , Hedger Nicholas , George Roana Liz , Chandra Goutam , Mohanakumar Kochupurackal P , Chakrabarti Bhismadev , Rajamma Usha
Published: January 2025

The ability to attend to social stimuli is fundamental for processing social cues and shaping social behavior, yet cultural variability in this capacity remains relatively unexplored. Social attention is typically tested using preferential-looking paradigms in labs, which have demonstrated that autistic individuals attend less to social stimuli. Such studies are limited, by the fact that they have almost all been conducted in Western Europe and the USA. To address this gap, our objective was to test the cultural generalizability of these results by investigating whether autistic symptoms are negatively associated with social attention in a traditionally understudied sample: Indian adults. Additionally, we tested the specificity of this relation by investigating whether a similar association exists with the traits of attention-deficit/hyperactivity disorder (ADHD). Our study involved 121 young adults from Kerala, India. Autistic and ADHD traits were evaluated using the Autism Spectrum Quotient (AQ) and Adult ADHD Self-Report Scale (ASRS), respectively. The participants' gaze behavior was recorded during a preferential-looking task, where pairs of social and non-social images were presented simultaneously. Individuals with higher autistic traits exhibited a reduced preference for social stimuli. No such association of social attention was noted with ADHD traits. Follow-up analysis of AQ subscales indicated that the association between gaze duration and autistic traits was driven by the social, and not the attention to detail factor of autistic traits. Our results provide new evidence for the cultural generalizability of the social attention task and offer the potential for culture-agnostic phenotypic assessments for adults with autism.
Impact of Zingiber officinale on Testicular Morphometry, Sperm Quality, and Hormonal Profiles in Alcohol-Induced Toxicity
Authors: Esomchi Collins Nduka , Nwofia Joy Onyinyechi , Nwoke Favour Kyrian , Egwu Ogugua Augustine
Published: January 2025

Background: Alcohol consumption is known to induce reproductive toxicity, leading to adverse effects on testicular morphology, sperm quality, and DNA integrity in males. Zingiber officinale (ginger), known for its antioxidant and anti-inflammatory properties, may counteract these effects. This study aimed to investigate the impact of ginger on testicular morphometry, sperm quality, and hormonal profiles in alcohol-induced toxicity. 30 male Wistar rats were divided into six groups (n=5/group). Group A (control) received normal saline. Group B was exposed to 40% alcohol (3.50 g/kg body weight) from Days 15–28. Group C received ginger (750 mg/kg) during the same period. Groups D, E, and F were treated with alcohol for 14 days, followed by low (250 mg/kg), medium (500 mg/kg), and high (750 mg/kg) doses of ginger, respectively, from Days 15–28. The study evaluated changes in body and testicular morphometry, antioxidant enzyme and hormonal changes. Semen analysis included sperm motility, count, and morphology, while sperm chromatin/DNA integrity was assessed using Aniline Blue and Toluidine Blue staining.
Results: Alcohol exposure (Group B) significantly reduced testicular weight, sperm motility, and chromatin integrity. Ginger-treated groups (C, D, and E) showed marked improvements, with Group C outperforming the control group (A) in sperm motility, antioxidant levels, and hormones. However, Group F showed distorted results similar to Group B, suggesting high-dose toxicity.
Conclusion: Ginger improves reproductive health and mitigates alcohol-induced toxicity in a dose-dependent manner. Moderate doses show optimal benefits, while high doses may be detrimental. These findings support ginger’s potential as a natural therapeutic agent for reproductive health.
Interpretable Prognostic Modeling for Long-Term Survival of Type A Aortic Dissection Patients Using Support Vector Machine Algorithm
Authors: Cai Hao , Shao Yue , Liu Xuan-yu , Li Chang-ying , Ran Hao-yu , Shi Hao-ming , Zhang Cheng , Wu Qing-chen
Published: January 2025

Objective
This study aims to develop a reliable and interpretable predictive model for the risk of long-term survival in type A aortic dissection (TAAD) patients, utilizing machine learning (ML) algorithms.
Methods
We retrospectively reviewed the clinical data diagnosed with Type A Aortic Dissection (TAAD) who underwent open surgical repair at our institution between September 2017 and December 2020. Cases with less than 20% missing data were imputed using random forest algorithms. To identify significant prognostic factors, we performed LASSO (Least Absolute Shrinkage and Selection Operator) Cox regression analysis, including preoperative blood markers, previous medical history and perioperative condition. Based on the advantages of the model and the characteristics of the dataset, we subsequently developed a machine learning-based prognostic model using Support Vector Machine (SVM) and evaluated its performance across key metrics. To further explain the decision-making process of the SVM model, we employed SHapley Additive exPlanation (SHAP) values for model interpretation.
Results
A total of 175 patients with TAAD were included in the study. Through LASSO Cox regression, univariate analysis, and clinical relevance assessment, eight feature variables were selected for modeling. Performance evaluation revealed that the SVM model showed excellent performance in both the training and test sets, with no significant overfitting, indicating strong clinical applicability. In the training set, the model achieved an AUC of 0.9247 (95% CI: 0.9200–0.9279), and in the testing set, 0.8800 (95% CI: 0.8492–0.9396). The accuracy was 0.8663 and 0.8857, precision was 0.8627 and 1.0000, recall was 0.8713 and 0.7333, F1 score was 0.8670 and 0.8462, Brier score was 0.1068 and 0.1070, average precision (AP) was 0.9266 and 0.9086, and C-index was 0.8901 and 0.8700, respectively. SHAP analysis identified that longer ICU hospital stay, abdominal pain, plasma transfusion volume, creatinine, white blood cell count, operation time, and systemic immune-inflammation index (SII) had significant positive impact on the model's predictions.
Conclusion
This study developed an interpretable predictive model based on the SVM algorithm to assess long-term survival in TAAD patients. The model demonstrated accuracy, precision, and robustness in identifying high-risk patients, providing clinicians with reliable evidence for prognosis management.
Global Burden of Disease of interstitial lung disease and pulmonary sarcoidosis in adolescents and young adults (1990–2019)
Authors: He Xiaoshuang , Wang Lu , Zhao Yu , Qu Yuanyuan , Xin Wenyan , Xu Lina , Li Wanyu , Wu Chao
Published: January 2025

Background: Interstitial lung disease (ILD) and pulmonary sarcoidosis are common respiratory diseases that are difficult to diagnose and costly to treat. Adolescents and young adults (AYAs) aged 15–39 years are frequently overlooked in global burden estimates despite their unique epidemiological and societal implications. Comprehensive global burden estimates are lacking. To address this gap, we analysed the results of the Global Burden of Disease Study (GBD) 2019, focusing on Disability-Adjusted Life Years (DALYs).
Methods: Using the GBD 2019 dataset, we calculated age-standardised rate of incidence, mortality, and DALYs and their average annual percentage change from 1990–2019 across various factors, including sex, socio-demographic index (SDI), and geographic region. Decomposition analyses explored the impacts of population growth, changing age structures, and epidemiological changes on ILD incidence, DALYs, and mortality in AYAs globally and across different SDI and GBD regions.
Results: In 2019, there were 2.6 million cases of ILD and pulmonary sarcoidosis in AYAs, and 3,428 deaths were attributed to these diseases. Age-standardised incidence and DALY rates significantly increased between 1990 and 2019. Females experienced higher rates than males. Standardised DALY rates decreased in high and middle–high SDI countries but increased in low, middle–low, and low-SDI countries. The primary reason was population growth, significantly impacting areas in the lower SDI quintiles.
Conclusions: This study provides recent epidemiological data on the burden of ILD and pulmonary sarcoidosis in AYAs. These findings highlight the importance of targeted control measures to reduce the burden in this age group.
Increased Survival Associated with Experience-based Treatment in Primary Intracranial Yolk Sac Tumor and a systematic review
Authors: Guo Teng-xian , Liu Zhenxing , Li Bohan , Wu Zhen
Published: January 2025

OBJECTIVE
Primary intracranial yolk sac tumors are rare neoplasms with poor prognosis. The study aimed to identify adverse factors affecting survival and to propose an appropriate treatment.
METHODS
We reviewed the clinical data of 68 patients with primary intracranial yolk sac tumors in our cohort and performed a systematic review of 28 cases published between 1976 and 2019.
RESULTS
Our series included 54 male (79.4%) and 14 female (20.6%) patients, with a median age at diagnosis of 12 years. Twenty-eight patients experienced recurrence, 6 patients developed metastasis, and 28 patients died at the final follow-up. Multivariate analysis revealed that surgery combined with chemotherapy and radiation significantly increased both progression-free survival (p<0.001) and overall survival (p<0.001). As noted in our prior literature, 10 patients developed recurrence, 4 patients experienced metastasis, and 7 patients died during their follow-up time. In the pooled cases, multivariate analysis revealed that surgery with chemotherapy and radiation significantly prolonged progression-free survival (p<0.001). and increasing age (p=0.009) and surgery with chemotherapy and radiation (p<0.001) significantly increased overall survival.
CONCLUSIONS
Surgery plus adjuvant therapy was a favorable factor for both progression-free survival and overall survival in patients with yolk sac tumors.
Association Between Liver Fibrosis (FIB-4) Index and Vertebral Fracture in Middle-aged and Older Adults in the United States: A Cross-Sectional Study of NHANES 2013-2014
Authors: Gou Yuwei , Yin Heng , Wen Yongjie , Xie Xiansong , Wang Zhoujing , Chen Qian , Zhang Yingbo , Xie Haiyang
Published: January 2025

Objective
This study was to examine the association between FIB-4(fibrosis index based on four factors) and the occurrence of vertebral fractures in Middle-aged and Older Americans.
Methods
Patients ⩾45years of age from the 2013–2014 NHANES database were selected for this study. Restricted cubic spline models and weighted logistic regression models were used to assess the association between FIB-4 and the occurrence of vertebral fractures in Middle-aged and Older Americans. The predictive value of the FIB-4 on the occurrence of vertebral fractures was assessed using receiver operating characteristic curves (ROC). To examine the robustness of the main findings, a sensitivity analysis was conducted.
Results
A total of 2188 patients were included in the analysis, of whole 147 suffered vertebral fractures. Fully adjusted logistic regression showed a significant linear relationship between FIB-4 and the occurrence of vertebral fracture in Middle-aged and Older Americans (P < 0.05),with a linear relationship observed between the FIB-4 index and the risk of vertebral fractures. Additionally, the FIB-4 index demonstrated good predictive performance for the incidence of vertebral fractures.
Conclusions
This study found that the FIB-4 index, as a novel and non-invasive liver fibrosis biomarker, can predict the risk of vertebral fractures in middle-aged and older Americans, which has clinical significance for the prevention and management of vertebral fractures in middle-aged and older Americans.
Comparative Analysis of Clinical Outcomes Between Neoadjuvant Chemoimmunotherapy and Neoadjuvant Chemoradiotherapy in Patients with Resectable Locally Advanced Esophageal Squamous Cell Carcinoma: A Multicenter, Retrospective Study
Authors: Yan Xue , Peng Ying , Mo Peng , Li Liuyu , Jiang Weijing , Zhang Wenzhen , Xu Yuanji , Su Miaoyi , Shen Yongshi , Fu Zhichao
Published: January 2025

Background
Patients with locally advanced esophageal squamous-cell carcinoma (LA-ESCC) generally experience poor prognosis after surgery. Neoadjuvant therapy has shown potential to improve survival outcomes. This study aimed to compare the long-term efficacy and safety of neoadjuvant chemoimmunotherapy (nCIT) versus neoadjuvant chemoradiotherapy (nCRT) in patients with LA-ESCC.
Methods
This multicenter study included patients with LA-ESCC treated at three hospitals in China between November 2015 and January 2024. Patients underwent either nCIT or nCRT followed by surgical resection. The primary endpoint was the 3-year overall survival (OS) rate. Secondary outcomes included objective response rate (ORR), pathologic complete response (pCR) rate, major pathologic response, disease-free survival (DFS), OS, and treatment-related adverse events. Propensity score matching was employed to adjust for baseline differences.
Results
A total of 225 LA-ESCC patients were included in this study, with 87 patients receiving nCRT and 138 patients receiving nCIT. After propensity score matching adjustment, each group have 87 patients included. The nCRT group demonstrated significantly superior outcomes to nCIT group in terms of ORR (85.06% vs. 45.98%, p < 0.001), T stage down rate (78.16% vs. 58.62%, p = 0.006), N stage down rate (85.06% vs. 45.98%, p < 0.001) and pCR rate (37.90% vs 14.90%, p < 0.001). The median follow-up duration was 44.5 months for the nCIT group and 35.1 months for the nCRT group. The nCIT group exhibited better 3-year OS (75.90% vs 55.60%, P < 0.05) andDFS (66.40% vs. 47.30%, P = 0.009) compared to the nCRT group. Subgroup analysis indicated that LA-ESCC patient with N + or non cT4 stage who received neoadjuvant chemoradiotherapy followed by esophagectomy had better OS and DFS. Univariate and multivariate Cox regression analyses identified clinical N stage as an independent prognostic factor for both OS and disease-free survival across both cohorts.
Conclusion
Neoadjuvant chemoimmunotherapy followed by esophagectomy is a promising treatment strategy for locally advanced resectable esophageal squamous cell carcinoma. nCRT may provide greater benefits in patients with N + or non-cT4 stage disease.
S100A9 Promotes Resistance to Anti-PD-1 Immunotherapy in Hepatocellular Carcinoma by Degrading PARP1 and Activating the STAT3/PD-L1 Pathway
Authors: Zhou Xianwei , Qiao Chu , Chu Xuehui , Man Haoran , Liu Jingxin , Li Yunzheng , Li Huan , Shan Xiaodong , Wang Weihong , Lian Zaowu , Lu Yanjun , Yu Decai , Sun Xitai , Li Binghua
Published: January 2025

Background
Immune checkpoint inhibitors (ICIs), such as anti-programmed cell death protein-1 (PD-1) immunotherapy, have emerged as promising treatments for advanced hepatocellular carcinoma (HCC), significantly improving clinical outcomes. However, resistance to ICIs remains a major challenge, and the underlying mechanisms of this resistance are not yet fully understood. This study aimed to investigate the role of S100 calcium-binding protein A9 (S100A9) in mediating resistance to anti-PD-1 therapy.
Approach and Results:
We conducted RNA sequencing (RNA-seq) on tumor samples from anti-PD-1 responders and non-responders in HCC patients. Differential expression analysis identified S100A9 as a potential driver gene of resistance to anti-PD-1 therapy. Subcutaneous tumor models and an orthotopic HCC model established via hydrodynamic transfection were utilized to evaluate the impact of S100A9 on the efficacy of PD-1 therapy. Our findings revealed that S100A9 promotes resistance to anti-PD-1 therapy in HCC. Mechanistically, S100A9 directly interacted with PARP1 and induced its degradation via the ubiquitin-proteasome pathway. This process increased STAT3 phosphorylation at Tyr705, thereby enhancing PD-L1 transcription. Notably, treatment with the S100A9 inhibitor Tasquinimod significantly improved the efficacy of anti-PD-1 therapy in HCC.
Conclusions
Our study reveals that S100A9 facilitates immune evasion in HCC by enhancing PARP1 ubiquitination, STAT3 phosphorylation, and PD-L1 expression. Furthermore, combining S100A9 inhibitors with anti-PD-1 antibodies markedly enhances the therapeutic efficacy of ICIs in HCC. These findings highlight S100A9 as a potential therapeutic target for overcoming resistance to immunotherapy in HCC.
Nomogram Prediction Model on hospital mortality in patients after surgery with non-traumatic intracerebral hemorrhage: a retrospective analysis of the MIMIC-IV database
Authors: Wang Yu-Mei , Lu Jiaqi , Zhou Yi-Min , Tian Ying , Shi Guangzhi , Lv Yi
Published: January 2025

Background
The study aimed to investigate the association of clinical data in intensive care unit (ICU) with the hospital mortality, and constructed a prediction model on the prognosis in patients with non-traumatic intracerebral hemorrhage (ICH).
Methods
We extracted all clinical information in ICU of patients with non-traumatic ICH from the Medical Information Mart for Intensive Care IV (MIMIC-IV). Logistic regression analysis was used to analyzing the risk factors. A nomogram for predicting the hospital mortality was constructed with R software and validated. Afterwards, the effectiveness and accuracy of the model were tested and evaluated.
Results
In the MIMIC IV database, 2004 patients with non-traumatic ICH were included in the study, with 1403 in training cohort and 601 in validation cohort. The mortality of hospital was 20.0% and 20.1% in the training and validation cohort, respectively. Age, Sequential Organ Failure Assessment Score (SOFA score), maximal mean blood pressure (Mbp), maximal temperature, glumbg and white blood cell count(WBC) were independent risk factors. The patients with higher glumbg and WBC were more likely to have poor prognosis (glumbg: p < 0.001, OR 1.018, 95% CI 1.010–1.025; WBC: p = 0.006, OR 1.057, 95% CI 1.016–1.099). The nomogram for predicting model exhibited a good performance and calibration. The AUC was 0.8022(0.7741–0.8303). The calibration curve indicated a satisfactory level of fit.
Conclusion
Non-traumatic ICH was associated with high rate of mortality (20%). The nomogram constructed in the study included age, SOFA score, maximal Mbp, maximal temperature, glumbg and WBC. Therefore, dynamic monitoring of these factors may be beneficial in assessing the risk and predicting the prognosis of the patients admitted to ICU with non-traumatic ICH.
Measurement Invariance of the CESD-R-10 Among Adolescents over the Transition from Paper to Online Administration
Authors: Gohari Mahmood R , Ferro Mark A. , Patte Karen , MacKillop James , Leatherdale Scott T
Published: January 2025

Despite the prevalence of online surveys, research validating paper-based scale measurement properties for online use is lacking. We assessed the measurement invariance of the 10-item CESD-R-10 scale in adolescents transitioning from paper to online administration. We analyzed 2-year linked data from 2,831 Canadian secondary school students during 2019/20 and 2020/21. Using structural equation modeling, we examined measurement invariance across configural, metric, scalar, and strict stages due to the COVID-19 pandemic shift to online surveys. Baseline mean depression score was 8.2 (SD = 5.9), with 33.7% (N = 953) reporting clinically relevant symptoms. We found measurement invariance between paper and online administration. The results support measurement invariance in males, while partial scalar invariance for females when thresholds of items 6 (I felt fearful) and item 9 (I felt lonely) are freely estimated between the two administrations. Our findings demonstrate that the CESD-R-10 remains invariant even with a shift in data collection mode from paper to online surveys. This study supports the validity of conducting meaningful comparisons of depression symptoms when changing the mode of data collection in survey research among adolescent samples.
Educação em saúde sobre complicações crônicas do Diabetes Mellitus
Authors: CRUZ Aline Ribeiro da , FONSECA Beatriz Gonçalves Barbosa da , GOMES Graziela Gama da Conceição , SODELLI Júlia Vinhati , COSTA Safira Pontes de Almeida , COSTA Sueli de Souza
Published: January 2025

Ações de educação em saúde são fundamentais ao considerar-se a promoção de informação à população, no que diz respeito ao controle, prevenção e retardamento de questões inerentes às doenças presentes, como o Diabetes Mellitus (DM). Nesse sentido, o presente relato tem como objetivo descrever a experiência dos autores na elaboração e na efetivação de uma ação educativa realizada por meio de palestra, oferta de material informativo gratuito e criação de espaço para diálogo, sobre as complicações crônicas do DM, com foco na conscientização dos cidadãos presentes no local. A ação foi desenvolvida por meio da metodologia da problematização com o uso das cinco etapas do Arco de Maguerez. O planejamento desse evento ampliou a habilidade de interação com o público, além da capacitação da população acerca de medidas para melhora de hábitos de vida e identificação de sintomas, essenciais ao tema proposto, implicando no melhor prognóstico e na menor sobrecarga do sistema de saúde.
Establishment of an orthotopic model of endometrial cancer
Authors: Frantsiyants E. M. , Shikhlyarova A. I. , Kaplieva I. V. , Bandovkina V. A. , Pogorelova Yu. A. , Neskubina I. V. , Trepitaki L. K. , Surikova E. I. , Moiseenko T. I. , Cheryarina N. D. , Kotieva V. M. , Vereskunova A. A. , Menshenina A. P. , Rogozin M. A. , Ishonina O. G. , Ushakova N. D.
Published: January 2025

The purpose of this study was to establish a model of uterine carcinoma in female laboratory rats by transplanting Guerin carcinoma directly into the uterine horn. Material and Methods. Fifteen nonlinear white laboratory rats weighing 250 ± 25 g served as the subjects of surgical intervention. all operative interventions were performed under xylazine-zoletil anesthesia. Female white laboratory rats were laparotomized under aseptic conditions using anesthesia. the incision length was 2 cm, and a tumor suspension containing 2.5-3.5×106 cells was injected into the lumen of the right uterine horn using an intravenous catheter with a 22G injection port (0.9 × 25 mm). tumor cells were counted using the ADAMIILS cell analyzer (Nano Entek, Korea). the tumor progression was monitored for 21 days. after euthanizing the animals under ether anesthesia, median longitudinal histological sections, 5–7 μm thick, were made from the tumor node and stained with hematoxylin-eosin and Van-Gizon using standard techniques. Results. Following the transplantation of Guerin’s carcinoma cell suspension, a tumor node of approximately 25 mm in diameter was identified macroscopically in the region of the inferior aspect of the right uterine horn. additionally, the presence of haemorrhagic effusion was documented in the abdominal cavity and tumor screenings. at light microscopy, areas of neutrophilic infiltration, significant narrowing of the lumen of the uterine horn with signs of involution, and prismatic epithelium of papillary structures were observed. the tumor cell features characteristic of Guerin’s carcinoma are preserved in the tumor node induced in the uterus, with a cytoplasmic-nuclear ratio that remains close to 1:1. the shapes of the nuclei vary, but the irregular ovoid shape remains dominant, and pathological mitotic figures are observed. the tumor stroma includes cytoplasmic branched connections connecting the tumor conglomeration. Conclusion. therefore, according to the morphological description, the presented experimental model demonstrates the possibility of intrauterine growth of Guerin’s carcinoma in animals and is most similar to the localization of the tumor focus in patients with gynecological cancer.
snoRNA box C/D levels in leukemia cells in chromosomal abnormalities after irradiation
Authors: Rastorgueva E. V. , Pogodina E. S. , Iurova E. V. , Beloborodov E. A. , Sugak D. E. , Tumozov I. A. , Saenko Yu. V. , Fomin A. Ni.
Published: January 2025

The study objective. This paper reviews the express of C/D box snoRNAs (small nucleolar RNAs) and possibility of their use as biomarkers of radioresistance in chromosomal abnormalities. Material and Methods. The study compared the values of log2FC express of snoRNA C/Dbox in radiosensitive (HL-60) and radioresistant (K562) cell lines with different levels of chromosomal abnormalities. The cells were irradiated with X-ray radiation once at a dose of 4 Gy. The expression of snoRNA C/D was evaluated 1, 4 and 24 hours after irradiation, using new generation sequencing (NGS) MiSeq. Results. Different log2FC values were obtained in HL-60 and K562 cell lines 1 hour, 4 and 24 hours after irradiation. Positive expression of C/D snoRNA prevails in HL-60 throughout the experiment. In K562, the predominance of positive values of C/D snoRNA expression was observed 4 hours after irradiation, and negative values of log2FC were observed 24 hours later. the more anomalies there were in the chromosome, the greater the difference in expression we observed. at the same time, the number of C/D snoRNA changed maximally 24 hours after irradiation in the studied cell lines. We noted a greater number of C/D snoRNAs in the HL-60 cell line, and only 3 expressed C/D snoRNAs in the 15th marker chromosome in K562 out of 16 in HL-60 in the same chromosome. Conclusion. Our study showed a low informative value of using C/D snoRNAs family as markers of radiosensitivity in the presence of chromosomal abnormalities in cancer cells.
Development of a mathematical model of dependence of specific volumetric electrical resistance of SIW-4 insulation on factors affecting its reliability
Authors: Denisov I. V.
Published: January 2025

Insulation of self-supporting insulated wire (SIW-4) is the object of the study, and the subject of the study is a mathematical model of the dependence of the specific volume electrical resistance of the SIW-4 insulation on the factors affecting its reliability. The resulting mathematical model will allow us to proceed to the development of a method for predictive assessment of the residual life of the insulation material of the conductor under study. At the first stage of the work, the influence of external factors on the electrical parameters of the SIW-4 insulation material has been studied. When forming the goal of the study, namely, obtaining a mathematical model of the dependence of the specific volume resistance of the wire insulation on the influence of external factors, difficult operating conditions have been taken into account. SIW-4 is intended for use outside buildings, i. e. it is exposed to solar radiation, wind load, precipitation, temperature changes, etc. Within the framework of this study, the following most significant factors have been considered: alternating electric current, ambient temperature and period of operation. These factors have been selected taking into account the possibility of conducting a multifactorial experiment and fully characterize such properties of product reliability as durability and failure-free operation. During the multifactorial analysis, the task was to select the minimum and maximum values of each factor under study, followed by the compilation of a planning matrix for a full factorial experiment. The resulting mathematical model allows us to determine the effective value of the specific volume electrical resistance of the SIW-4 insulation material depending on its operation under the given specific conditions. It also opens up the possibility of developing the second stage of the study, associated with the construction of an algorithm for the method of predictive assessment of the residual life of the insulation material of the conductor under study.
Efficiency increasing of a shipyard power supply system
Authors: Beley V. F. , Korotkikh K. V.
Published: January 2025

The development of the shipbuilding industry involves increasing the competitiveness of manufactured products, replacing obsolete electrical equipment, and increasing the efficiency of power supply systems. The introduction of the latest technologies reduces the weight and size of equipment, expands their functionality, but these technologies are based on nonlinear and asymmetrical power consumers, which causes a negative impact on the power grid. The power supply system of the Baltic Shipyard "Yantar" is characterized by a significant share of nonlinear, asymmetrical loads, often single-phase. An integrated approach to the analysis of the plant's power supply system included experimental studies of nonlinear power consumers, during which a high level of higher current harmonics (3rd, 5th and 7th orders) was established. One of the effective methods for reducing zero-sequence voltage asymmetry is to replace a transformer with a Y/Y0 winding connection diagram with a Δ/Y0 diagram. Circuit and technological solutions (separation of nonlinear loads to a separate bus system; increasing the phase of semiconductor converters; connecting a nonlinear load to a system with greater short-circuit power) and filtering devices (narrow-band filters, filter-balancing devices and active filters) are used to increase the efficiency of the power supply system when it operates under conditions of increasing distorting loads.
Cooling of animal products in an air-gas environment of carbon dioxide
Authors: Aldamatov N. E. , Bredihin S. A. , Neverov E. N.
Published: January 2025

In our country, as well as throughout the world, special attention is paid to finding more modern, energy-efficient and environmentally friendly methods of cooling food products, including animal ones. The basis of most technological processes of refrigeration treatment is working fluids, which can be natural or synthetic substances. Due to the negative impact of synthetic raw materials on the environment, preference is given to substances of natural origin. The greatest interest in the last twenty years in the world community of refrigeration equipment and technology is shown to carbon dioxide. This refrigerant is actively used in traditional vapor-compression refrigeration machines. In Russia carbon dioxide as a working substance in closed cycles of refrigeration machines is found at industrial facilities whose operation is based on cascade cycles. In this case, carbon dioxide acts as a working substance of the lower cascade, since it belongs to high-pressure refrigerating agents. Until 2022, carbon dioxide-based refrigerants were also actively developed at transcritical temperature levels, where the condensation temperature of carbon dioxide is close to ambient temperatures. In this study, carbon dioxide will be considered as a refrigerant when it interacts with the product in an air-gas environment during sublimation, in which carbon dioxide changes its aggregate state from snow-like to gaseous.
Pine nut shell as a sorbent in fruit winemaking
Authors: Ivanova K. R. , Privalova E. A.
Published: January 2025

Reducing the must acidity is a critical task in fruit winemaking due to the need to create favorable conditions for the yeast development and the fermentation of sugars. Acid reduction methods used in traditional winemaking are not suitable for fruit must, since they do not effectively eliminate malic acid which is the main contributor to the fruit wines acidity. The study has examined the possibility of using the adsorption method to reduce the acidity of must obtained from Ussuri pear fruits (titratable acidity of 15.5–18.7 g/dm3) using specially prepared pine nut shells as a sorbent. The must was treated with pine nut shells in a static mode and with stirring; the treatment duration varied from 2 h to 10 days. The pine nut shells have good adsorption capacity for acids contained in pear must and can reduce their amount by 27 %. It has been experimentally established that the pine nut shells have low selectivity for technologically important components of the must and also sorb fermentable sugars and polyphenolic compounds, which may result in an undesirable decrease in the sugar-acid index (SAI) of the must. An increase in the degree of grinding the nut shells helps to increase its adsorption activity. Changing the must processing mode allows you to select conditions under which it is possible to achieve the recommended SAI values.
A numerical approach for calculating exact non-adiabatic terms in quantum dynamics
Authors: Lawrence Ewen , Schmid Sebastian F J , Čepaitė Ieva , Kirton Peter , Duncan Callum W
Published: January 2025

Understanding how non-adiabatic terms affect quantum dynamics is fundamental to improving various protocols for quantum technologies. We present a novel approach to computing the Adiabatic Gauge Potential (AGP), which gives information on the non-adiabatic terms that arise from time dependence in the Hamiltonian. Our approach uses commutators of the Hamiltonian to build up an appropriate basis of the AGP, which can be easily truncated to give an approximate form when the exact result is intractable. We use this approach to study the AGP obtained for the transverse field Ising model on a variety of graphs, showing how the different underlying graph structures can give rise to very different scaling for the number of terms required in the AGP.
Culinary connections: The mediating role of customer brand co-creation behavior in gastronomic and revisit intentions
Authors: Made Purnami Ni , Wayan Mujiati Ni , Putu Laksmi Danyathi Ayu , Siwi Kartika Sari Uswatun , Komang Dea Marcellina Putri Darmada Desak
Published: January 2025

The increasing competition in the culinary tourism industry highlights the need for businesses to better understand customer behavior to encourage repeated visits. This study investigates the mediating role of customer brand co-creation behavior in the effect of gastronomic experience on revisit intention among Generation Z café visitors in Bali, Indonesia. Data were collected from 250 respondents via an online survey and analyzed using Partial Least Squares Structural Equation Modeling. The analysis reveals that gastronomic experience has a significant positive impact on revisit intention (β = 0.479, p < 0.05) and customer brand co-creation behavior (β = 0.534, p < 0.05). Additionally, customer brand co-creation behavior positively influences revisit intention (β = 0.380, p < 0.05) and mediates the relationship between gastronomic experience and revisit intention (β = 0.203, p < 0.05). These findings suggest that providing high-quality gastronomic experiences, focusing on food, service, and environment, and encouraging active customer participation in co-creation activities can significantly enhance the likelihood of repeat visits. By fostering deeper customer participation and brand co-creation behavior, businesses can significantly enhance revisit intention, which is essential for long-term success in the competitive culinary tourism sector. These findings contribute to a better understanding of the dynamics between gastronomic experiences, customer brand co-creation behavior, and revisit intentions.
AcknowledgementThis research was funded by LPPM Universitas Udayana, Indonesia with contract number: B/255.108/UN14.4.A/PT.01.03/2024.
Humanistic Leadership for Organizational Learning Capability: Integration of Maqashid Syariah and Knowledge Management
Authors: Nurcahyo Satria Avianda , Anis Muhammad , Thoha Anis Malik
Published: January 2025

This research aims to explore the application of humanistic leadership within the Ministry of Religion, Semarang Regency, particularly in how it enhances organizational learning capability (OLC) through the perspectives of Maqasid Syariah and knowledge management.Humanistic leadership emphasizes human values, interpersonal relationships, and self-development within organizations. This study explores how humanistic leadership can improve OLC through the perspectives of Maqasid Syariah and knowledge management. Using a qualitative method with in-depth interviews, data was collected from employees regarding their perceptions and experiences with humanistic leadership, Maqasid Syariah principles, and knowledge management practices. Thematic analysis identified patterns in the application of these principles in the work environment. Findings indicate that humanistic leadership significantly fosters a work atmosphere conducive to learning and innovation. The incorporation of Maqasid Syariah values, like spiritual and intellectual well-being, supports an ethical and inclusive organizational culture. Additionally, effective knowledge management practices, such as documentation and knowledge sharing, reinforce OLC by motivating and engaging employees in continuous learning. This research underscores the importance of integrating humanistic leadership with Maqasid Syariah and knowledge management in organizational development strategies. The Ministry of Religion can leverage these findings to enhance employee performance and capability, promoting the achievement of organizational goals more sustainably.
Resilience in Santri: The Impact of Social Support on the Quran Memorization Journey
Authors: Al Afghani Abdullah Azzam , Fakhria Milcha
Published: January 2025

Memorizing the Qur’an is a spiritual endeavor that is noble yet filled with significant challenges. Many Qur’an memorizers face various obstacles throughout this journey. This study investigates the role of social support in fostering resilience among Qur'an memorizers who simultaneously fulfill dual roles as students. Conducted with 180 santri from five pondok pesantren in Central Java, aged 15-19, the study adopts a non-experimental quantitative design. Findings indicate that emotional support (β=0.306, p < 0.01) and informational support (β=0.237, p < 0.01) significantly predict resilience, while instrumental support does not (β=0.154, p > 0.05). Adding companionship increased the explained variance of resilience to 42.7% (R²=0.427, F(1,175) = 9.730, p < 0.001). These findings underscoring the importance of peer support, guidance from kyai (religious mentors), and a supportive environment in sustaining the challenging process of Qur’an memorization. This study implies that for Qur'an memorizers, resilience is strengthened by companionship, guidance, and emotional support, which collectively enable them to navigate the spiritual and academic challenges of their journey.
Desórdenes abióticos asociados con palmas ornamentales en la Ciudad de México
Authors: Alvarado Rosales Dionicio , Luz de Lourdes Saavedra-Romero  , Alejandra Almaraz-Sánchez  , Andrés Quezada-Salinas  , Silvia Edith García-Díaz  , Sergio Aranda-Ocampo  , Carlos Fredy Ortiz-García  , Armando Equihua-Martínez  , José Abel López-Buenfil  , Roberto Quintero-Campos
Published: January 2025

Las palmeras de la CDMX se encuentran en proceso de declinación y muerte y, a la fecha, se han identificado distintos agentes bióticos que incentivan el problema. El diagnóstico de desórdenes abióticos no ha tenido la misma atención, a pesar de que estos pueden predisponer el ataque de otros agentes en las plantas y ocasionar su muerte. Con estas bases, el presente estudio tuvo como objetivo identificar desórdenes asociados a varias palmas de la ciudad. Se realizaron muestreos de síntomas inciertos en 50 sitios (35 transectos de 200 m, nueve de longitud variable, de los cuales se localizaron palmas con tres diferentes categorías de salud y otros seis puntos en donde se sospechó la presencia de agentes abióticos). Por palma, se midió el diámetro normal a 1.30 m sobre el nivel del suelo, altura total y ancho del camellón de plantación, y en los nueve transectos de longitud variable, también se colectaron muestras de suelo de las palmas con diferente categoría de salud y se determinó el grado de compactación del suelo (bajo o alto). En laboratorio, se determinó el pH (relación 1:2.5) y la conductividad eléctrica. La necrosis apical de foliolos se asoció con las altas temperaturas y la baja precipitación. Se encontraron pHs extremos (4.8 a 7.4), con un promedio de 6.4, valores de conductividad que oscilaron de 0.39 a 4.0 dS m-1, con un promedio de 1.62 dS m-1, grado de compactación de bajo a alto (de <20 a >60 golpes para alcanzar una profundidad de 20 cm) y espacio de crecimiento limitado (5.37 m en los sitios de longitud variable y 6.34 m en promedio en los transectos de 200 m). Finalmente, se detectaron síntomas típicos de deficiencia de potasio. Todos estos factores y otros no estudiados podrían estar actuando sinérgicamente en la predisposición de las palmas al ataque de agentes bióticos (enfermedades e insectos). Para priorizar su importancia individual y, en conjunto, se requiere de más investigación.
Design, Synthesis, Biological Evaluation and Docking Studies of 2-hydroxy-4-benzyloxy Chalcone Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease
Authors: Li Wei , Huang Jing , Chen Zhixin , Zhang Dan , He Lin , Guo Yan , Zhong Lei , Yang Chenwu , Yang Chunyan , Zeng Mei , Zhu Jiang , Cao Zhongcheng
Published: January 2025

Objectives:

Alzheimer's disease (AD) is the most prevalent neurodegenerative
disorder, but no drugs can cure this disease. Chalcones possess good antioxidant activity,
anti-neuroinflammatory activity, neuroprotective effects, inhibitory effects on Aβ
aggregation, and Aβ disaggregation ability. Therefore, chalcones are ideal lead compounds,
and the discovery of novel anti-AD agent-based chalcones is necessary.

Methods:

Hydroxy groups and aryl benzyl ether groups were introduced into chalcone
scaffolds to obtain a series of 2-hydroxyl-4-benzyloxy chalcone derivatives. These derivatives
were further synthesized, biologically evaluated, and docked.

Results:

Most target derivatives exhibited good anti-AD activities. In particular, compound
11d had excellent inhibitory effects on self-induced Aβ1-42 aggregation (90.8% inhibition
rate at 25 μM) and Cu2+ induced Aβ1-42 aggregation (93.4% inhibition rate at 25
μM). In addition, it also exhibited good Aβ1-42 fibril disaggregation ability (64.7% at 25
μM), significant antioxidative activity (ORAC = 2.03 Trolox equivalent), moderate
MAO-B inhibition (IC50 = 4.81 μM), selective metal chelation, appropriate BBB permeation,
and dramatic anti-neuroinflammatory ability. In addition, compound 11d relieved
AD symptoms and protected hippocampal neurons in vivo.

Conclusion:

Compound 11d is a promising multifunctional anti-Aβ agent.
Combinatorial Synthesis of Tetrasubstituted Alkenes and Related Compounds with Potential Anticancer Activity
Authors: Nováčková Kateřina , Drož Ladislav , Kořínek Marek , Sedlák David , Bartůněk Petr , Eigner Václav , Havránek Miroslav
Published: January 2025

Objective:

In search of efficient anticancer agents, we aimed at the design and synthesis
of a library of tetrasubstituted alkenes. These are structural analogues of tamoxifen, one of
the widely used anticancer therapeutics.

Methods:

Our small organic compound library was prepared via a chemical synthesis in the solution
using the Larock three-component coupling reaction, which is known to tolerate diverse
functional groups. Further, we have integrated this synthetic approach to four- and fivecomponent
alkene assembly by using Sonogashira coupling, A3 and AHA reactions. The final
products were isolated through preparative LC/MS station and characterized by NMR, MS, and
X-ray crystallography. The biological activity of all novel compounds was tested by luciferase
reporter assays against estrogen receptor (ER) and androgen receptor (AR).

Results and Discussion:

Our combinatorial synthetic approach was based on structurally diverse
internal alkynes, arylboronic acids and aryl halides. After experiment optimization a "one-pot"
single synthetic procedure was developed. This allowed us to prepare a small-sized screening library
of novel tetrasubstituted alkenes quickly and efficiently without laborious intermediate isolation.
In most cases, we isolated the final product as a single isomer, and in selected cases, we
confirmed their chemical structure via X-ray crystallography. High throughput screening of the
novel tetrasubstituted alkenes revealed a dozen hits with predominant agonistic ERα- and antagonistic
AR-activity in the micromolar range.

Conclusion:

The proposed combinatorial approach is applicable for the synthesis of diversified
organic compound libraries and for the discovery of new tamoxifen analogues with an improved
therapeutic profile.