bluuebunny/crossref_metadata_2025 huggingface dataset:
A GHAZAL NOT INCLUDED IN THE DIVAN OF MUHIBBI AND TAHMIS BY ŞEMSI TO THIS GHAZAL
Authors: Kaplan Hasan
Published: November 2024

In classical Turkish literature, there are poems which are not included in the divans of poets, for various reasons. Mecmuas/collections of these poems, and poets not having a divan, are important resources. It is possible to find unknown poems or poets in some archival documents, in addition to collections. One of the aforementioned archive materials is registered in file number 324 and folder number 27 in the sources of Ottoman Archives at Topkapi Palace Museum MA.e, the Directorate of State Archives. The document includes 41 ghazals (lyric poems, a form with its roots in seventh-century Arabia that is composed of five to fifteen structurally and thematically autonomous couplets), 1 tahmis/making five, 4 stanzas/quatrains and 1 distich/couplet written by 8 poets. This document containing 18 ghazals of Muhibbî and nazires (imitation, interpretation, reply in kind) written after his poems has some parallels with the nazire mecmua/imitation collection edited by Mehmed Izzî, probably in the 16th century.
There exist 13 imitations written by Bâkî to Sultan Suleiman in the document authenticating the collection organized by Mehmed Izzî and including unknown poems of the poets such as Dâʻî, Khalîl, and Şemsî. The document also includes a imitation competition reported by Gubârî. What makes the document the relevant to this study is that it includes a poem not included in the Divan of Sultan Suleiman published by both Ak and Yavuz, and a tahmis written on his poem by a poet with the pseudonym Şemsî. In this study, firstly it was examined whether the poem in question is by Sultan Suleiman or not, later examining if this tahmis might belonged to which Şemsî. As a result of the study, it is clear that the poem belongs to Muhibbî, and İsfendiyarzâde Ahmed Şemsî (Shemsî) Paşa (Pasha) -one of the 16th century poets- has made a tahmis to this lyric poem.
Mesenteric thrombosis as a clinical presentation of antiphospholipid syndrome: a case report and literature review
Authors: Dzul Jose E. , Sonda Valeria G. , Carrillo Carolina , Segura Vanesa Lopez
Published: November 2024

Mesenteric thrombosis is a rare pathology that results from the obstruction of the arterial or venous system of the mesenteric circulation by a thrombus or embolus. The etiology of thrombus formation is rarely evident; the population statistically most affected by this pathology are older adults, with an average age of 60-70 years. The main causes related to the presentation of mesenteric thrombosis are embolic cardiac arrhythmias such as atrial fibrillation, neoplasia and prolonged prostration. In rare cases, the presence of thrombophilia, for example antiphospholipid antibody syndrome (APS), is identified as an underlying cause of thrombotic events. APS is a disease characterized by a procoagulant state; the most frequent clinical manifestations are related to thrombotic events. The pathophysiology of the disease is related to the formation of antiphospholipid antibodies. The three antibodies identified in APS are lupus anticoagulant (LA), anticardiolipin antibody (aCL) and anti-b2glycoprotein 1 antibody (anti-b2GP1). Treatment is based on the use of anticoagulant drugs with the aim of preventing the appearance of new thromboembolic events. In this article we present a clinical case of mesenteric thrombosis in a male patient in whom the presence of antiphospholipid antibodies (aPL) was documented and who met the classification criteria for APS. For the review of the literature, a search was carried out for information related to pathophysiology, clinical manifestations, classification and treatment of APS, as well as literature related to mesenteric thrombosis in open access sources and databases such as PubMed. In conclusion, APS is a rare pathology, probably because it is underdiagnosed, since in developing countries there are no resources to carry out the diagnostic approach, likewise the delay in the start of treatment implies an increase in morbidity for the patient.
Assessing the post-pandemic socioeconomic and health impacts on daily wage and private sector workers in India: a cross-sectional analysis
Authors: Narathattil Akhila , Vasanthan Gindhuja , Mohammed Abidha , Sujathan Arathy
Published: November 2024

Background: The COVID-19 pandemic, a global health and socioeconomic crisis, has severely impacted various demographics, with daily wage and private sector workers in India among the hardest hit. Lockdown measures, aimed at curbing the virus's spread, resulted in widespread job losses, financial instability, educational challenges, and mental health issues, leading to a critical examination of the post-pandemic effects on these vulnerable populations. This study aims to assess the socioeconomic and psychological impacts of COVID-19 on daily wage and private sector workers. Specifically, it examines employment and income loss, access to basic needs, educational disruptions, lifestyle changes, and mental health effects post-lockdown.
Methods: A cross-sectional survey was conducted with 100 participants selected through simple random sampling. Data collection spanned from October to December 2023, utilizing a structured questionnaire to capture sociodemographic, economic, lifestyle, and psychological information. The depression, anxiety and stress scale-21 items (DASS-21) scale was employed to measure depression, anxiety, and stress levels among respondents.
Results: Results show that 42% of participants experienced job losses, predominantly among daily wage workers, with many respondents also reporting decreased financial stability. Educational impacts were notable, with limited access to digital learning tools exacerbating the digital divide. Significant lifestyle changes included shifts towards healthier habits and increased compulsive behaviours, such as handwashing. Mental health assessments indicated that 30% of participants had mild depression, while moderate levels of stress and anxiety were common.
Conclusions: The findings highlight the pandemic's lasting socioeconomic and mental health toll on daily wage and private sector workers in India. Immediate policy interventions are needed to strengthen social support systems, ensure access to mental health care, and facilitate economic recovery for these communities.
Assessment of the adsorption capacity of biochar samples obtained from agricultural biomasses
Authors: Machado de Souza Débora , Melo de Souza Marluci , Cardoso Pereira Fernanda , Konzen Severo Bruna , Andrade Brehm Feliciane , Alberto Mendes Moraes Carlos
Published: November 2024

The study consists of adsorption tests on two samples of biochar, obtained from rice husk and coconut fiber biochar biomass, as well as a sample of charcarbon, both prepared under different conditions: macerated and non-macerated; impregnation with and without HCl and H3PO4; and washing or not with deionized water after impregnation. The test was performed in duplicate, for 30 min, with masses of 0.5 g; 0.3 g; 0.1 g; and 0.05 g, and an initial methylene blue concentration of 0.01 g∙L-1. The study was carried out with the objective of identifying, in the analyzed samples, the material with the greatest adsorption capacity of methylene blue dye, comparing the data with commercial activated carbon. The results identified removal above 70 % in both types of biochars, suggesting the feasibility of application as an adsorbent material to remove organic contaminants. The sample that most closely resembled the removal percentage of commercial activated carbon (98.84 %) was that of biochar obtained from coconut fibers, with 91.71 %. Thus, the research showed promise in studying the application and valorization of biochars, produced from agro-industrial waste, in adsorption processes.
Advancements and clinical applications of extended platelet-rich fibrin (E-PRF)
Authors: Vinayaka Ambujakshi Manjunatha
Published: November 2024

Extended platelet-rich fibrin (E-PRF) has emerged as a potent biological agent in regenerative medicine and dentistry. It leverages the natural healing capacities of growth factors and cytokines from platelets and leukocytes to promote tissue repair. This systematic review explores the role of E-PRF in various clinical applications, including wound healing, bone regeneration, and periodontal therapy. The findings indicate that E-PRF provides an enhanced bioactive matrix, supporting superior clinical outcomes compared to conventional treatments. Future studies should focus on optimizing E-PRF protocols and investigating its long-term effectiveness.
Artefacts in tissue processing: A review
Authors: Singh Priyanka , Anjum Rubeena , Jehan Ayeda , Vijay Pradakhshana , Khanam Wajiha , Kousar Azra
Published: November 2024

An artificial feature in tissue sections that is self-colored and unrelated is called an artefact. This has been an age long cause of misinterpretation that leads to misdiagnosis. It can result in alteration of normal morphologic and cytologic features that may occur as a result of the way the tissue has been handled, right from the time the biopsy, which is surgically obtained till the entire histopathological procedures of fixation, processing, embedding, sectioning and staining are performed on it. This article reviews the common artefacts encountered during tissue processing.
Orthodontics for orthognathic surgery: A review
Authors: Malshetwar Sumedha Surendranath , Naik Thirumal , Naik Seena , Padala Rahul Goud , Aparna Kuchana , Gattu Vinay
Published: November 2024

Malposition teeth or obvious jaw deformities; are conditions that require orthodontics for orthodontic correction but a combined approach with surgery. Severe deformities that require a combination of orthodontics and surgery for correction are called dentofacial deformities. Surgery to straighten the jaws or relocate dentoalveolar segments is the sole option for patients whose orthodontic problems are so severe that neither growth modification nor concealment can help. Surgical treatment is not a substitute for orthodontics in these patients. Coordinated with orthodontics, other dental treatments and surgery are necessary, to achieve good overall results. Significant advancements in the past several years have allowed for the correction of many serious issues that were untreatable just a few years ago with combination treatment.
Improving life quality via mandibular reconstruction: Innovations and techniques – A literature review
Authors: Aravind Anto B  , Agrawal Ankush Kumar , Ajmera Shruti , Sharma Amit Kumar , Sharma Vikram , Meena Pooja
Published: November 2024

Mandibular abnormalities can arise from a range of causes, including illnesses, trauma to the face, and surgical excision of tumors. These conditions can significantly affect daily activities such as eating, speaking, and even grooming. These functions are impaired without appropriate repair, which has a major negative impact on an individual's quality of life. Mandibular reconstruction aims to preserve facial symmetry and allow patients to regain their normal ability to chew food by restoring both the structure and functionality of the jaw. A successful restoration also takes into account elements such as the positioning of implants to restore oral function and, in certain cases, the reconnecting of the inferior alveolar nerve to enhance feeling.

Mandibular reconstruction has undergone a revolutionary change in technique over the years. These developments are still ongoing, with the goal of improving patient recovery and outcomes. This article highlights the continuous attempts to improve surgical techniques and integrate new technologies for improved patient care. It gives a general review of the historical evolution, contemporary approaches, and prospective future possibilities in mandibular reconstruction.
A rare case of mucocele of the Blandin and Nuhn glands with review of literature
Authors: Gombra Virender , Thillaikarasi R
Published: November 2024

Oral mucocele is the most common benign minor salivary gland lesion of the oral cavity. Usually it occurs on lower lip, buccal mucosa and ventral surface of the tongue and rarely seen on ventral surface of the tongue, floor of mouth and palate. It is classified in two types of lesions, one is extravasation type which is more common and other is retention type. We present case report of a 37-year-old healthy male with complaint of swelling on ventral surface of the tongue, which was sessile, soft and fluctuant with smooth overlying mucosa with diagnosis of mucocele associated with Blandin and Nuhn gland. Management included marsupialization and drainage of thick mucus secretions. This article discusses on clinical features, diagnosis and management of mucoceles associated with Blandin and Nuhn gland.
Understanding oral malignancies: 2 case reports
Authors: Shanthi M , Angela Donna T , Divya VC , Ganesh C , Deepika Divya , Hamsavardini
Published: November 2024

The clinical presentation, diagnosis, and management of several squamous cell carcinoma cases are covered thoroughly. Roughly 94% of all mouth malignancies are squamous cell carcinomas. Race, gender, and age group differences exist in annual incidence and mortality rates. This percentage is 7.7 per 100,000 in the US. Like other carcinomas, intraoral carcinoma is more common in older adults, especially in men. Individuals with oral SCC have often known about an abnormality in that area for four to eight months prior to seeking professional medical attention. Early growth is characterized by little discomfort, which may account for the delay in seeking professional assistance. The clinical manifestations of oral SCC include exophytic, endophytic, leukoplakic, and erythroplakic, all of which exhibit apparent surface alterations.

Tobacco usage, excessive alcohol consumption, HPV infection, eating little fruits and vegetables, prolonged sun exposure, and having a compromised immune system are risk factors. Improving outcomes requires early discovery and treatment, which may include chemotherapy, radiation therapy, surgery, or a combination of these. In order to improve the prognosis for oral cancer, early identification and intervention are crucial. Survival risk from squamous cell carcinoma is often low. This article emphasis on the clinical presentation of oral malignancies.
An Observational Study on The Role of Magnetic Resonance Imaging in The Evaluation of Soft Tissue Tumors with Histopathological Correlation at Tertiary Care Centre
Authors: Sripriya Sriramula , Mogalagunta Tejaswini , Bajaj Sunitha , Bindu Sudha , T Madhavi
Published: November 2024

Background: The primary aim of this study is to evaluate the role of magnetic resonance imaging (MRI) in the assessment of soft tissue tumors with histopathological correlation at a tertiary care center.
Methods: An observational study was conducted on 75 patients (n = 75) in the Department of Radiodiagnosis over 18 months. The targeted population comprised patients who presented to the Radiodiagnosis Department for radiological imaging of soft tissue tumors.
Results: Out of 75 cases, 20% were found to have benign tumors, while 80% were found to have malignant tumors. The most frequent benign tumor was fibromatosis, with n = 10 cases (13.33%), and the most common malignant tumor was synovial sarcoma, with n = 14 cases (18.66%). The benign age group ranged from 11 to 20 years. T2-weighted heterogeneous hyperintensity was noted more frequently in malignant lesions, demonstrating a high positive predictive value; that is, 83% of malignant tumors exhibited changes on diffusion-weighted imaging/ apparent diffusion co efficient (DWI/ADC). Low-grade malignant lesions showed no restrictions. Most benign lesions displayed restrictions, with a high positive predictive value of 98.14%, specificity of 93.33%, and sensitivity of 88.33%.
Conclusions: Soft tissue tumors can be detected and locally staged using MRI; thus, this technique has proven its value. Intralesional hemorrhage and calcification are two parameters that have been shown to have no substantial association with cancer. Due to its high sensitivity, MRI is a viable option for evaluating soft tissue tumors.
Laparotomy Versus Laparoscopy Cholecystectomy for Surgical Treatment in Patients with Gallstone Disease: A Comparative Cost-Effectiveness Analysis
Authors: Dehcheshmeh Nayeb Fadaei , Abdollahi Hamed , Haghighizadeh Mohammadhosein , Faraji-Khiavi Farzad
Published: November 2024

Background: Due to the increasing costs of the healthcare system and limited financial resources, healthcare policymakers should adopt more cost-effective strategies.
Objectives: This study aimed to compare the cost-effectiveness of laparotomy cholecystectomy with laparoscopy.
Methods: This economic evaluation was conducted on patients with cholecystitis who were candidates for surgery in a private hospital in Ahvaz in 2021. Data collection tools consisted of four parts: (1) demographic information checklist; (2) clinical information checklist; (3) cost checklist; and (4) effectiveness assessment tool. SPSS22 and STATA14.2 were used for data analysis. One-way sensitivity analysis and Tornado diagrams were performed using Tree Age software.
Results: The mean total effectiveness score in patients treated with laparoscopy was 83.44 (SD = 11.34), which was higher than those treated with laparotomy at 68.39 (SD = 13.61). This difference was statistically significant in all effectiveness criteria, except for postoperative infection rates and length of operation (P < 0.001). The mean cost for patients undergoing laparoscopy was significantly higher than for those undergoing laparotomy ($481.43 vs. $459.49). However, overall, laparoscopic treatment (5.77) was more cost-effective than laparotomy (6.71). The laparoscopic procedure was approximately $1.47 per effectiveness unit cheaper than laparotomy, according to the ICER. One-way sensitivity analysis showed that the laparoscopic method remained more cost-effective, even when adjusting for cost and effectiveness components.
Conclusions: Although laparoscopic cholecystectomy was more expensive than laparotomy cholecystectomy, it was generally more cost- effective. The results of this research may assist Iran’s healthcare policymakers and managers in promoting laparoscopic cholecystectomy in hospitals.
A Narrative Review on the Conceptual and Methodological Advancements in Digital Disruption: A Way to Improved Quality of Services in Health Care
Authors: Kanade Devika , Kale Shailendrakumar , Reddy Mamatha GS , Mathur Ankita
Published: November 2024

Background: The adoption and successful implementation of digital health solutions heavily depend on digital health literacy, which is particularly critical in the current COVID-19 era. Low levels of digital health literacy are associated with poor preventative practices, the spread of inaccurate information, vaccine hesitancy, and reduced subjective well-being. Thus, the aim of this review was to highlight areas of current scholarly interest and identify any gaps in the literature regarding conceptual and methodological advancements in digital disruption.
Methods: The authors conducted a literature search using the databases Scopus, Embase, Web of Science, PubMed, and Google Scholar, focusing on papers released between 2003 and October 2023. The following keywords were used to conduct a thorough literature search: ((digital health OR digital disruption OR digital dental health)) AND (medical health OR telemedicine)), ((online doctor OR online consultation OR online health app)) AND (COVID-19 OR pandemic)). A total of 1,244 studies were screened, including duplicates and non- English research. After applying inclusion and exclusion criteria, 72 articles were selected for the review.
Results: A total of 72 articles were included in this review. The studies discussed the potential reasons for disrupted access to healthcare, which is linked to avoidable hospital admissions. Delayed care due to disruptions can lead to disease progression, the exacerbation of existing conditions, and chronic ambulatory care-sensitive conditions. Digital health innovations were presented as solutions to enhance care, reduce clinical workload, and promote independent living.
Conclusions: In conclusion, this narrative review provides a comprehensive overview of the conceptual and methodological advancements in digital technology related to healthcare. It demonstrates the potential of digital technology to revolutionize both medical and dental education.
The Strategies to Improve Primary Health Care Services: A Scoping Review
Authors: Habibi Farhad , Ehsani-Chimeh Elham , Olyaeemanesh Alireza , Mohamadi Sara , Salehi Sahar , Mohamadi Efat , Mobinizadeh Mohammadreza , Zarforoush Amin , Aboee Parisa
Published: November 2024

Context: Evaluation of health policies and identification of their challenges are vital for improving and implementing reforms in the healthcare system. The present study was conducted to identify interventions aimed at improving primary healthcare (PHC) services in Iran.
Evidence Acquisition: This research utilizes a scoping review to examine reform interventions in PHC services across 10 selected countries: Qatar, Oman, Turkey, Georgia, Armenia, United Arab Emirates, Saudi Arabia, Bahrain, Kazakhstan, and Kuwait. The study covers areas such as the PHC delivery system, human resource management, financial mechanisms, and the framework of community participation and intersectoral collaboration from 2010 to 2022.
Results: The main reform strategies for PHC systems in the reviewed countries included the establishment of family medical centers with nurse support as a comprehensive strategy for service provision in public health centers; providing comprehensive and quality healthcare service packages including maternal and child health, infectious disease immunization, chronic disease monitoring, and dental care services; health education; access to essential medications; improvement of electronic health services; implementation of health promotion and continuous prevention programs; capacity enhancement; and a greater focus on health screening programs and grading of healthcare centers.
Conclusions: The major findings from the reviewed countries indicate that healthcare policymakers focus on providing preventive care services, reducing maternal and child mortality, and increasing life expectancy. Programs such as referral systems, service grading, and the adoption of electronic health services are part of their reform agenda.
Principle Concepts in Futures Studies: A Narrative Review
Authors: Fard Zahra Heydari , Maleki Mohammad Reza , Pourasghari Hamid
Published: November 2024

Context: Our world is characterized by a dynamic landscape of variations, complexities, uncertainties, and ambiguities (VUCA). These elements manifest in various domains, including politics, economics, communication, information, science, and research, all of which significantly impact our lives. It is crucial for policymakers and managers to adopt a forward-thinking approach to comprehend these VUCA elements and their implications for the future. The future will undoubtedly differ from the present and the past. However, humans possess an inherent desire to understand and anticipate the future, particularly in the face of uncertainty. Therefore, exploring and understanding the future is not just a curiosity, but a necessity. Futures Studies can serve as a valuable tool in this context, enabling us to efficiently leverage opportunities and resources to navigate the chaotic environment. Review studies play a pivotal role in this process by reviewing existing work and synthesizing knowledge in a specific field. This study aims to collate findings related to the key concepts of Futures Research, thereby contributing to our collective understanding and preparation for the future.
Erratum for Evaluation of Validity Indices of Spiritual Competence Questionnaire. Health Technology Assessment in Action [Health Tech Asmnt Act. 2021; 5(1)]
Authors: Miri Masoumeh , Dastjerdi Reza , Younesi Mohammad Reza Asadi , Pakdaman Majid
Published: November 2024

The Article Abstract is not available
Frequency of Shiga Toxin Associated Genes in Escherichia coli Isolated from Salivary Abomasum Disease in Kid Goats
Authors: Chegeni Saba Almasi , Esmaeili Hossein , Lotfalizadeh Peyman
Published: November 2024

Background: Salivary abomasum disease (SAD) is a devastating disease causing significant mortality in Iranian goat and sheep herds. Understanding the causative agents is essential for developing effective preventive measures. This study investigated the potential role of Shiga toxin-producing Escherichia coli (STEC) in SAD pathogenesis.
Methods: We isolated E. coli from kid goats aged 3-30 days experiencing a sudden, acute illness characterized by gait imbalance, and death within 48 hours during the kidding season. Following isolation, we employed multiplex PCR to identify the presence of Shiga toxin genes (Stx1 and Stx2) associated with virulence in STEC strains.
Results: E. coli was isolated from 30 (75%) out of 40 animals. Notably, 7 (23.3%) isolates harbored the Stx2 gene, while only one isolate (3.3%) possessed the Stx1 gene.
Conclusion: These findings suggest a potential role for STEC, particularly strains carrying the Stx2 gene, in the development of SAD and multiple abomasal hemorrhages, in kid goats. The presence of Shiga toxin genes in a significant proportion of E. coli isolates highlights the importance of further research to elucidate their contribution to SAD pathogenesis and inform the development of targeted interventions.
Diagnosis of Chlamydia abortus by Isolation in Cell Culture and Real Time PCR in Aborted Sheep and Goats
Authors: Esmaeili Hossein , Hamedi Mona , Madani Seyed Ahmad , Barin Abbas , Haji Agha Khiyabani Fatemeh
Published: November 2024

Background: Ovine enzootic abortion (OEA) caused by Chlamyidia abortus is one of the most important abortive disease in small ruminants. Diagnosis of Ovine enzootic abortion depends on the isolation and detection of the agent or its nucleic acid. The aim of the present study was to detect Chlamydia abortus using both isolation method and real-time PCR in Brucella free flocks in Iran.
Methods: Twenty-eight vaginal and conjunctival swab samples which were Chlamydia abortus seropositive, were selected from ewes and does with recent abortion. Then the samples were tested by real-time PCR and positive molecular samples were inoculated into McCoy cells.
Results: Using real-time PCR, 18 samples (64.3%) were positive and 7 (25%) of them were isolated in cell culture.
Conclusion: The present results indicate that Chlamydia can play a relatively significant role in the abortion in does and ewes in Iran. Although the isolation of Chlamydia abortus have 100% specificity, because of low sensitivity, time consuming, cost and high probability of contamination, it is not suitable for routine laboratory diagnosis. Therefore, applying real-time PCR which have high sensitivity and specificity is recommended.
Impact of Nano-Pomegranate Seed Oil on the Expression of TLR2 and TLR4 Genes in A549 Cells Sensitized with Alternaria alternata Cellular Extract
Authors: Joghataei Seyed Mehdi , Nikaein Donya , Nezhad Ghazale Arshadi , Khosravi Alireza , Tamai Iradj Ashrafi
Published: November 2024

Background: Allergies impact nearly 30% of the world's population, with fungi being remarkable contributors to allergic sensitivity. Exposure to fungi allergens can trigger allergic reactions and severe asthma has been linked to hypersensitivity to fungi such as Aspergillus and Alternaria spp. Alternaria alternata, a common allergen in respiratory allergic diseases, releases proteases that initiate Th2 responses, causing inflammatory cytokine production. Given the anti-inflammatory properties of Pomegranate Seed Oil (PSO) and the potential of Nano-emulsions (NEs) to enhance drug delivery, this study investigates the impact of PSO-loaded NEs on TLR2 and TLR4 gene expression in A549 cells sensitized with A. alternata extract (ALT).
Methods: A. alternata (ATCC 6663) was cultured and processed to obtain a cytosolic extract, with protein content measured using the Bradford method. Using a Soxhlet apparatus, PSO was extracted from cleaned, dried seeds and analyzed by gas chromatography. Alginate nanospheres containing PSO were prepared through a modified water-in-oil emulsification method and characterized for particle size, polydispersity index, and zeta potential. A549 cells were cultured and treated with various ALT, PSO, and PSO-loaded NEs combinations. Following treatment, RNA was extracted, and real-time RT- PCR was conducted to analyze TLR2 and TLR4 gene expression.
Results: All treatment groups showed an increase in TLR2 gene expression compared to the control, with the ALT combined with PSO (P+ALT) causing the highest increase at 4.82-fold. Free PSO (P) and free NEs (NP) resulted in 3.92-fold and 2.93-fold increases, respectively, while the ALT and PSO- loaded NEs (NP+ALT) led to 2.26-fold and 2.50-fold increases. For TLR4 gene expression, the ALT treatment increased expression by 2.29-fold, but treatments containing PSO (P, P+ALT, NP+ALT) reduced TLR4 expression, with P+ALT and NP+ALT causing 0.45-fold and 0.61-fold decreases.
Conclusion: The study confirms that herbal extracts like PSO selectively upregulate TLR2 and downregulate TLR4, suggesting targeted therapeutic potential in inflammation and immune modulation. PSO-loaded NEs demonstrated superior anti-inflammatory effects, supporting their development for treating inflammatory diseases and warranting further research into their molecular mechanisms and therapeutic applications.
Exploring the Phytochemical Profile and Antimicrobial Potential of Leaf Extracts from Megaphrynium macrostachyum
Authors: Ibrahim Salisu Danjuma , Ariyo Olatomiwa Olubunmi , Aigbodion Aireguamen I. , Hilary Ifijen Ikhazuagbe , Abraham Oyiguh Joseph , Aminu Ruth Foluke , Ohiocheoya Benjamin Ewanole , Igbako Philip Okiemute , Akpala Ndah Sumaila
Published: November 2024

Background: Medicinal plants offer a promising reservoir of bioactive compounds, placing them as a compelling avenue for novel drug exploration. In recent times, the emphasis on harnessing natural products sourced from medicinal plants has escalated due to their diminished adverse effects, economic viability, and efficacy against a broad spectrum of antibiotic-resistant microorganisms. The aim of this investigation was to scrutinize the phytochemical constitution and antimicrobial efficacy inherent to Megaphrynium macrostachyum leaves.
Methods: Three distinct solvents – ethanol, water-ethanol, and water – were employed to extract the diverse range of phytochemicals housed within the leaves. Subsequently, the extracted compounds were subjected to assessment for their antimicrobial potential against both bacteria and fungi, which were isolated from various samples. This evaluation was executed employing the agar well diffusion method.
Results: The qualitative analysis of phytochemical components unveiled the substantial presence of alkaloids, terpenoids, phenols, tannins, flavonoids, while a relatively lower occurrence of steroids was observed across the different leaf extracts. Further quantitative analysis showed that the most potent extract exhibited elevated phenolic content (2.400 mg/ml), closely trailed by flavonoids (1.995 mg/ml) and saponins (1.909 mg/ml). This study furnishes compelling proof of the efficacy encompassed within Megaphrynium macrostachyum leaves, particularly concerning their proficiency against both fungi and bacteria.
Conclusion: As such, it adds momentum to the accumulating body of knowledge concerning theexploitation of natural medicinal plants, paving the way for enhanced therapeutic interventions.
The Prevalence of Fluoroquinolone-Resistant E. coli in Animals and Animal Products: A Systematic Review and Meta-Analysis
Authors: Ebrahim-Saraie Hadi Sedigh , Amini Mohammad Esmaeil , Hasannejad-Bibalan Meysam , Zadgari Ervin , Bakhshi Arash
Published: November 2024

Background: Biological contamination of foods is a serious problem for human health. Animal and animal products may be contaminated by these biological and chemical contaminants. One of the most important causes of foodborne illness in humans is Escherichia coli. Fluoroquinolones can be used as a suitable treatment for enteric infections in food-producing livestock. We aimed to evaluate the current status of resistance of E. coli strains isolated from animals and animal products to fluoroquinolone in Iran.
Methods: A systematic search was conducted using the Web of Science, PubMed, Embase, Google Scholar, and Scopus databases from 2000 to Oct 2020. Nineteen studies were selected based on the inclusion criteria and analysis by Comprehensive Meta-Analysis.
Results: Based on the data analysis, The rates of antibiotic resistance in animal strains were as follows: Flumequine (75.1%), Enrofloxacin (55.2%), Danofloxacin (48.1%), Ciprofloxacin (48.4%), and Norfloxacin (52.9%). Next, the rates of quinolone resistance among E. coli strains isolated from animal products were Norfloxacin (45.5%), Ciprofloxacin (44.5%), and Enrofloxacin (60.9%). Based on the funnel plots and Egger's test, there was no significant publication bias.
Conclusion: We finally concluded that antibiotic resistance in commensal E. coli is related to the overuse of antibiotics in livestock, especially fluoroquinolones.
Javanese and Batak Tribes: The Role of Moderation in Parenting Style on Self-Control in Adolscents
Authors: Sudirman Dhiya Fauziyyah , Makruf Herlin Asfarina , Rodiyah Isyatin , Yuniardi Muhammad Salis , Karmiyati Diah
Published: November 2024

This research aims to determine the influence of parenting styles on self-control which is moderated by ethnicity in adolescents. The research design used is a correlational quantitative design. Sampling technique using method convenience sampling. The research used 2 scales, namely the Parental Style Inventory II (PSI-II) to measure parenting style and the Brief Self Control Scale to measure self-control. The data analysis technique in this research is using moderated regression analysis and simple regression tests. The research results show that ethnicity does not moderate the influence of parenting style on self-control (P Int_1 = 0.5323 > 0.05). Besides that, independent testing obtained significant results (parenting style influence self-control). However, when there is a covariate (another variable present), namely ethnicity and controlled simultaneously, it becomes insignificant (in the test using Hayes).
Design and Optimization of MicroSolar Grid for Off-Grid Rural Communities
Authors: Alam Khorshed , Mostakim MD Ali , Khan Md Shaiful Islam
Published: November 2024

This article provides an in-depth exploration of the design and optimization of micro solar grids for off-grid rural communities, focusing on their role as a sustainable energy solution. The global energy crisis, particularly in rural regions with limited access to the centralized grid, necessitates the exploration of decentralized energy systems. Micro solar grids, powered by solar energy, present an ideal solution, offering communities the ability to produce and consume their own electricity while reducing dependency on external power sources. This paper discusses the importance of micro solar grids as a renewable and reliable energy source that can significantly enhance the quality of life in rural communities, addressing issues such as energy access, poverty alleviation, and rural development.
The article delves into the technical aspects of designing a micro solar grid, including energy demand calculations based on the community’s needs, solar panel sizing, and the integration of energy storage solutions. The optimization of system performance is discussed, covering both technical and economic strategies to maximize energy output, improve system efficiency, and reduce costs. Key optimization techniques such as panel placement, battery storage management,
 
and energy distribution are emphasized to ensure reliable power supply, even during cloudy days or at night.
Effect of Hormones, Season and Lactation on Follicular Size, Oocyte Competency and Embryo Production in Sahiwal Cattle
Authors: Bramhaiah K. Veera , Krishna N. Venkata , Kumar G. Sandeep , Reddy K. Greeshma , Reddy Y. Nagendra , Tagore K.V.V. , Reddy D. Manjunath
Published: November 2024

Background: Transvaginal ultrasound-guided ovum pick-up (OPU) and in vitro embryo production (IVEP) techniques are widely used for enhancing reproductive efficiency. The number and quality of embryos have been reported to be influenced by various factors like source of hormones, season, lactation in cattle. Methods: Twenty-one multiparous, normal cyclic Sahiwal cows (aged: 6-8 years; lactating: n-11 and non-lactating: n-10) were selected randomly and the experiment was conducted during hot (April to September) and cold (October to March) seasons. All the donor cows were administered 10 µg GnRH at random stage of oestrous cycle followed by FSH (Folltropin-V™ or Stimufol) at the rate of 100, 60 and 40 mg after 48, 60 and 72 h of GnRH administration. After 24 hours of coasting period, follicular aspiration was performed by stabilizing the targeted follicles with the help of ultrasonography. The procedures of COCs grading, in vitro maturation, fertilization, followed by culture were performed as per the standard protocols. Results: The hormonal treatment was effective in improving the oocytes’ developmental competency and in vitro embryo production; with no statistical differences between the two sources. The follicle size distribution revealed a lower (P less than 0.05) medium-sized and small-sized follicular proportion during the hot season with a higher average count of dominant (large-sized) follicles. While, good quality (A+B+C) oocytes, matured and fertilized oocytes were significantly higher (P less than 0.05) in non-lactating donors, especially among cool-season collections.
Features of distribution of a number of rare and protected plant species in the territories of oligotrophic and mesotrophic mires within oil fields of Khanty-Mansi Autonomous Area – Yugra
Authors: Shishkonakova E. A.
Published: November 2024

The technogenic transformation of oligotrophic and mesotrophic mires, which occurs during the functioning of the infrastructure of oil fields, leads to the emergence of new habitats with fundamentally different conditions, previously uncharacteristic for these biogeocenoses. Expansion of areas of eutrophicated soils, pollution with oil and chlorides, subsequent reclamation measures, the formation of embankments from mineral soil – all these disturbance types create the preconditions for the disappearance of rare plants, however, in parallel, the introduction of new species that also have a protected status is noted. Transformed areas of mires can become refugia for endangered and protected plants. Three groups of plants can be distinguished, related to the nature of the technogenically transformed substrates on which they settle. The first group includes plants that settle exclusively on peat, the second includes species found on mineral substrates introduced into mires, the third group includes species that can grow both on mineral substrates and technogenically eutrophicated peat soils. The article provides characteristics of a number of transformed habitats that arose in the mire areas of the – Khanty-Mansi Autonomous Area – Yugra, within which rare and protected species were found. Among the plants whose distribution in the mires of the district is largely due to the expansion of human economic activity, mention should be made of Thelypteris palustris, Lycopodiella inundata, Typha angustifolia, liverwort Heterogemma laxa, etc.
The VII International Field Symposium was held in Yugra “West Siberian peatlands and the carbon cycle: past and present”
Authors: Kupriianova Iu. V. , Niyazova A. V. , Verevkina E. L. , Veretennikova E. E. , Shanyeva V. S. , Ilyasov D. V. , Akhmedova I. D. , Zmanovskaya A. S. , Lapshina E. D.
Published: November 2024

The article covers the results of the VII International Field Symposium "West Siberian Peatlands and the Carbon Cycle: Past and Present", which was held in the Khanty-Mansiysk autonomous okrug – Yugra (Khanty-Mansiysk, Beloyarsky) in August 16–26, 2024. The Symposium brought together over 180 scientists specializing in bog science, ecology and carbon balance. The main topics of the plenary and sectional sessions were: the role of bogs in the global carbon cycle, environmental modeling, biodiversity and ecology of bogs, biogeochemical cycles of natural andanthropogenically disturbed bog ecosystems, biogeochemistry of peat and bog waters, paleoecology and history of bog ecosystems development, the impact of modern climate change on forest-bog ecosystems. At the roundtable meetings, the participants discussed the possibilities of using unmanned aerial vehicles (UAVs) in the study and mapping of bog ecosystems, and shared their experience in implementation of forest-climate projects.
Multy-year dynamics of some physico-chemical parameters in mire water at the site of salt pollution of the raised bog (Vostochno-Surgutskoye oil field, Western Siberia)
Authors: Tyurin V. N. , Kharbaka V. A. , Maslovskaya O. V.
Published: November 2024

The article discusses the features of changes in some physico-chemical parameters of mire waters in raised bog (pH, electrical conductivity, chloride concentration) over a long period.
Uso estratégico de las TIC en el desarrollo de trayectorias educativas
Authors: Navarro-Roldán Claudia Patricia , Ramírez-Roncancio Nancy Lizeth
Published: November 2024

La era digital ha revolucionado profundamente la sociedad en todas sus dimensiones. Rápidamente, los ciudadanos hemos cambiado la forma en que accedemos al conocimiento y compartimos información, así como las formas en que trabajamos, nos orientamos en los espacios o compramos. Incluso, hemos transformado cómo gestionamos nuestra privacidad y nos relacionamos socialmente con la familia, los amigos o la pareja. Estos cambios son tan significativos que diferentes Gobiernos alrededor del mundo han volcado sus esfuerzos en formular y aplicar políticas públicas que promueven tanto la infraestructura como el uso de Tecnologías de la Información y Comunicación (TIC). A la par, buscan impulsar el desarrollo de capacidades humanas y empresariales que respondan a las exigencias de la era digital. En este contexto, organismos internacionales (e.g., OCDE, WEF, IFTF) reconocen la necesidad de adaptarse a un mundo en constante evolución y promueven la integración de las TIC en el aprendizaje y la investigación en la educación como una clave para el desarrollo global a largo plazo.
Les Misérables: Un análisis multimodal de la caracterización de personajes en la versión original y subtitulada al español latinoamericano de la película musical de Tom Hooper
Authors:   , Valdez Gomero, Marielli Adeli , Vegas Gutierrez, Anthony Alejandro
Published: November 2024

El interés en este trabajo emana del creciente uso de la teoría de la multimodalidad en estudios de traducción que aplican este marco teórico al análisis de productos audiovisuales y a la escasez de esta aplicación en el ámbito específico de la subtitulación de películas musicales. El objetivo general es analizar cómo la subtitulación al español latinoamericano influye en la caracterización de los personajes principales en la película musical Les Misérables de Tom Hooper. El corpus utilizado incluye el guion original de la película en inglés británico (texto fuente) y los subtítulos al español latinoamericano (texto meta). Para la recopilación y posterior análisis de esta información, se emplearon técnicas de análisis de contenido y contrastivo en una ficha de análisis contrastivo multimodal de creación propia y basada en los postulados de autores como Stöckl (2004), Serafini y Reid (2019), y Villanueva (2021). A partir del análisis, los resultados de la investigación se resumen en que, primero, el uso de metáforas guarda una relación con las escenas que presentan momentos con una intensidad emocional elevada. Segundo, el uso del acento cockney y la gramática conversacional sirven como marcadores de la clase socioeconómica ficticia de los personajes. Tercero, el discurso de justicia es un tema recurrente en el vocabulario de los personajes principales en dos niveles: justicia institucional y perspectivas individuales. Se concluye que la traducción y subtitulación deben considerar no solo las palabras y su significado, sino también el contexto visual, acústico y musical.
Cultura organizacional y su influencia en la satisfacción laboral de los colaboradores de empresas financieras en Lima Metropolitana, 2023
Authors:   , Laveriano Bravo Patrick Livio , Moscoso Inoñan Janina Alessandra
Published: November 2024

Cuadro de textoEl propósito de este estudio es determinar la relación entre la cultura organizacional y la satisfacción laboral de los colaboradores de empresas financieras en Lima Metropolitana, 2023. Para ello, se utilizó un enfoque cuantitativo, diseño no experimental y alcance correlacional, puesto que las variables y dimensiones implicadas no serán manipuladas. Con la finalidad de lograr los objetivos para aceptar las hipótesis, la técnica empleada es la encuesta y el instrumento un cuestionario con escala de Likert; se recoge la información cuantitativa de una muestra de 374 colaboradores de tres de las principales instituciones financieras de la ciudad de Lima: Interbank, Scotiabank Perú y Banco Falabella Perú. En los cuestionarios se consideraron 40 preguntas con escala de Likert para conocer el nivel de correlación de las variables. En los resultados se hallaron la directa correlación de la cultura organizacional en la satisfacción laboral de los colaboradores. El estudio concluye en que hay una directa y significativa relación de ambas variables de la investigación científica.
Afrontamiento al estrés y Crecimiento Postraumático en Universitarios de Lima Metropolitana
Authors:   , Carrasco Torres Luis Abraham
Published: November 2024

El estudio evaluó la correlación entre estrategias de afrontamiento al estrés y crecimiento postraumático en estudiantes de psicología que perdieron a un ser querido. Participaron 200 personas (promedio de edad 21.0 años, DE = 2.4); 158 mujeres (79%) y 41 hombres (20.5%). Usando el Brief Cope-28 y el PTGI-MX, se encontró relación significativa positiva y de magnitud mediana “Apoyo emocional y social” (r=.395) y una relación significativa positiva y de magnitud grande con la dimensión “Afrontamiento activo y Planificación” (r=.516) con crecimiento postraumático. Los hombres usaron más el humor como afrontamiento, mientras que las mujeres usaron más la negación. Estudiantes que llevan terapia buscaron apoyo emocional y social con mayor frecuencia. Estos hallazgos guían nuevas intervenciones para mejorar bienestar y calidad de vida del estudiante.
Los procesos de producción de escritoras de fanfiction en plataformas especializadas y redes sociales
Authors:   , Calderon Santa Maria Karla Ximena
Published: November 2024

Las comunidades de fans son uno de los grupos sociales que cuentan con una gran presencia en internet y entre sus expresiones creativas más destacadas se encuentra el fanfiction. Esta actividad ha experimentado cambios a medida que los espacios y plataformas digitales han evolucionado. Considerando este panorama de transformaciones digitales, esta investigación tiene como objetivo analizar los procesos de producción de fanfiction en plataformas especializadas y redes sociales, desde el punto de vista de sus escritoras. Para desarrollarla, se aplicó la metodología cualitativa, donde se diseñó, validó y condujo entrevistas semiestructuradas a diez escritoras de fanfiction hispanohablantes. Los resultados indican que los procesos de producción de fanfiction se realizan a través de subprocesos individuales y colaborativos, los cuales son moldeados por las particularidades y dinámicas de las plataformas especializadas y las redes sociales. De esa manera, se confirma una transformación y adaptación en la producción del fanfiction, así como de los espacios en línea donde se desarrollan los fandoms y sus actividades.