bluuebunny/crossref_metadata_2025 huggingface dataset:
Leveraging ICN and SDN for Future Internet Architecture: A Survey
Authors: Aldaoud Manar , Al-Abri Dawood , Awadalla Medhat , Kausar Firdous
Published: April 2023

Information-Centric Networking (ICN) and Software-Defined Networking (SDN) are both new evolving network architectures that are receiving a lot of attention from researchers. ICN is a Future Internet architecture which tries to transform the current Internet architecture from location- and host-centric to content-centric, where obtaining requested data is achieved by the contents’ names regardless of the location of the data. From another angle, SDN is considered a new Internet architecture that moves the control plane management from network devices to a centralized controller. The SDN controller enhances network robustness and improves its scalability, reliability, and flexibility. The integration of ICN and SDN results in massive benefits, where SDN enhances ICN networks’ manageability, controllability, and functionality, and ICN reshapes the SDN design to make it compatible with ICN features and to enhance ICN in terms of network caching, routing, mobility, and security.. In this review paper, a comprehensive survey of the issues and challenges of integrating ICN and SDN is presented. Firstly, ICN’s main characteristics are summarized, and a short comparison between different ICN architectures is completed. Then, the key details of SDN are highlighted. Moreover, the motivation and benefits of merging ICN with SDN are summarized and the state-of-the-art work on merging ICN and SDN is reviewed and classified from several aspects. Finally, several open research issues are highlighted.
Approximating Max Function in Fully Homomorphic Encryption
Authors: Lee Hyunjun , Choi Jina , Lee Younho
Published: April 2023

This study focuses on efficiently finding the location of the maximum value for large-scale values encrypted by the CKKS (Cheon—Kim—Kim–Song) method. To find the maximum value, logM+1 comparison operations and logM rotation operations, and 2logM+3 additions and 2logM+1 multiplications are required. However, there is no known way to find a k-approximate maximum value, i.e., a value with the same most significant k-bits as the maximum value. In this study, when the value range of all data in each slot in the ciphertext is [0, 1], we propose a method for finding all slot positions of values whose most significant k-bits match the maximum value. The proposed method can find all slots from the input ciphertexts where their values have the same most significant k-bits as the maximum value by performing 2k comparison operations, (4k+2) multiplications, (6k+2klogM+3) additions, and 2klogM rotation operations. Through experiments and complexity analysis, we show that the proposed method is more efficient than the existing method of finding all locations where the k MSB is equal to the maximum value. The result of this can be applied to various privacy-preserving applications in various environments, such as IoT devices.
Design of a Compact Ultra-Wideband Microstrip Bandpass Filter
Authors: Li Chen , Ma Zhong-Hua , Chen Jia-Xiang , Wang Meng-Nan , Huang Jian-Mei
Published: April 2023

A compact ultra-wideband bandpass filter based on a multilayer printed circuit board (MPCB) structure is proposed in this paper. RO4450F prepreg is used to bond three RO4350B dielectric substrates with different thicknesses in the MPCB structure. The upper surfaces of the three dielectric substrates are respectively provided with copper-coated structures with different patterns. The blind holes and the defected ground structure (DGS) are added to the MPCB of an ultra-wideband bandpass filter. Two groups of loaded quarter-wavelength terminal-open stubs introduce two transmission zeros, which improves the roll-off rates and stopband characteristics, while simple DGS composed of rectangular slots introduces two resonance points in the passband to improve the return loss. Simulation and measurement are consistent. The insertion loss at the center frequency of 12.795 GHz is 0.58 dB and the fractional bandwidth of 3 dB is 40.33% from 10.215 GHz to 15.375 GHz. This bandpass filter can be widely used in wireless and satellite communication.
An Electric Vehicle Assisted Charging Mechanism for Unmanned Aerial Vehicles
Authors: Huang Chenn-Jung , Hu Kai-Wen , Cheng Hao-Wen
Published: April 2023

The global greenhouse effect and air pollution problems have been deteriorating in recent years. The power generation in the future is expected to shift from fossil fuels to renewables, and many countries have also announced the ban on the sale of vehicles powered by fossil fuels in the next few decades, to effectively alleviate the global greenhouse effect and air pollution problems. In addition to electric vehicles (EVs) that will replace traditional fuel vehicles as the main ground transportation vehicles in the future, unmanned aerial vehicles (UAVs) have also gradually and more recently been widely used for military and civilian purposes. The recent literature estimated that UAVs will become the major means of transport for goods delivery services before 2040, and the development of passenger UAVs will also extend the traditional human ground transportation to low-altitude airspace transportation. In recent years, the literature has proposed the use of renewable power supply, battery swapping, and charging stations to refill the battery of UAVs. However, the uncertainty of renewable power generation cannot guarantee the stable power supply of UAVs. It may even be very possible that a large number of UAVs need to be charged during the same period, causing congestion in charging stations or battery swapping facilities and delaying the arranged schedules of UAVs. Although studies have proposed the method of that employing moving EVs along with wireless charging technology in order to provide electricity to UAVs with urgent needs, the charging schemes are still oversimplified and have many restrictions. In addition, different charging options should be provided to fit the individual need of each UAV. In view of this, this work attempts to meet the mission characteristics and needs of various UAVs by providing an adaptive flight path and charging plan attached to individual UAVs, as well as reducing the power load of the renewable power generation during the peak period. We ran a series of simulations for the proposed flight path and charging mechanism to evaluate its performance. The simulation results revealed that the solutions proposed in this work can be used by UAV operators to fit the needs of each individual UAV.
Reproductive Ecology of the Chilean Round Ray (Urotrygon chilensis, Günther, 1872) in the Southern Gulf of California
Authors: Alvarez-Fuentes Carlos J. , Tovar-Ávila Javier , Payan-Alejo Jorge , Chávez-Arrenquín Darío A. , Salgado-Ugarte Isaias H. , Amezcua Felipe
Published: April 2023

The Chilean round ray (Urotrygon chilensis, Günther, 1872) is commonly caught as bycatch in the Mexican Pacific, but changes in its reproductive ecology as a consequence of fishery effects have never been investigated. In this work, the reproductive ecology of this species was determined in the Southern Gulf of California (SGC). Total length (TL) ranged from 11.4 to 51.6 cm, and females were larger than males. Size at maturity (TL50) was estimated at 27.5 cm for females and 25.3 cm for males. The seasonal variation of mature individuals, the presence of pregnant females, the mean oocyte size, the size of embryos and the smallest free-living specimens along the year suggest the existence of two reproductive periods during the year in the SGC, and the size of birth was estimated to be 11.2 to 15.6 cm TL. The average fecundity was 2.14 embryos. Spatial variations detected in size at maturity, fecundity, and reproductive cycle along the Mexican Pacific coast suggest the presence of separated populations. Some of these differences could be related to differences in maximum size attained in each region, though fishing pressure and environmental factors could have an important role, too.
Capsaicin Rich Low-Fat Salad Dressing: Improvement of Rheological and Sensory Properties and Emulsion and Oxidative Stability
Authors: Avci Esra , Tekin-Cakmak Zeynep Hazal , Ozgolet Muhammed , Karasu Salih , Kasapoglu Muhammed Zahid , Ramadan Mohamed Fawzy , Sagdic Osman
Published: April 2023

This study aimed to investigate the potential use of cold-pressed hot pepper seed oil by-product (HPOB) in a low-fat salad dressing to improve its rheological properties, emulsion, and oxidative stability. The total phenolic content (TPC), the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, and CUPRIC reducing antioxidant capacity (CUPRAC) values were 317.4 mg GAE/100 g, 81.87%, and 6952.8 mg Trolox/100 g, respectively. The capsaicin, dihydrocapsaicin, and total carotenoid content were 175.8 mg/100 g, 71.01 mg/100 g, and 106.3 µg/g, respectively. All emulsions indicated shear-thinning, viscoelastic solid-like behavior, and recoverable characteristics, which were improved via enrichment with HPOB. The thermal loop test showed that the low-fat sample formulated with 3% HPOB indicated little change in the G* value, showing that it exhibited high emulsion stability. The induction period values (IP) of the salad dressing samples containing HPOB (between 6.33 h and 8.33 h) were higher than the IP values of the control samples (3.20 h and 2.58 h). The enrichment with HPOB retarded the formation of oxidative volatile compounds of hexanal, nonanal, and 1-octene-3-ol. According to the results presented in this study, HPOB could be effectively used in a low-fat salad dressing to enhance its rheological characteristics and oxidative stability.
Role and Mechanism of Cold Plasma in Inactivating Alicyclobacillus acidoterrestris in Apple Juice
Authors: Ding Hao , Wang Tiecheng , Sun Yuhan , Zhang Yuxiang , Wei Jianping , Cai Rui , Guo Chunfeng , Yuan Yahong , Yue Tianli
Published: April 2023

A. acidoterrestris has been identified as the target bacterium in fruit juice production due to its high resistance to standard heat treatment. Multiple studies have shown that cold plasma can effectively inactivate pathogenic and spoilage microorganisms in juices. However, we are aware of only a few studies that have used cold plasma to inactivate A. acidoterrestris. In this study, the inactivation efficacy of cold plasma was determined using the plate count method and described using a biphasic model. The effects of the food matrix, input power, gas flow rate, and treatment time on inactivation efficacy were also discovered. Scavenging experiments with reactive oxygen species (•OH, •O2−, and 1O2), scanning electron microscopy (SEM), Raman spectra, as well as an in vitro toxicology assay kit, were used to determine the inactivation mechanism. According to the plate count method, a maximum reduction of 4.14 log CFU/ mL could be achieved within 7 s, and complete inactivation could be achieved within 240 s. The scavenging experiments showed that directly cold plasma-produced singlet oxygen plays the most crucial role in inactivation, which was also confirmed by the fluorescence probe SOSG. The scanning electron microscopy (SEM) and Raman spectra showed that the cold plasma treatment damaged the membrane integrity, DNA, proteins, lipids, and carbohydrates of A. acidoterrestris. The plate count results and the apple juice quality evaluation showed that the cold plasma treatment (1.32 kV) could inactivate 99% of A. acidoterrestris within 60 s, with no significant changes happening in apple juice quality, except for slight changes in the polyphenol content and color value.
Spent Grain: A Functional Ingredient for Food Applications
Authors: Chetrariu Ancuța , Dabija Adriana
Published: April 2023

Spent grain is the solid fraction remaining after wort removal. It is nutritionally rich, composed of fibers—mainly hemicellulose, cellulose, and lignin—proteins, lipids, vitamins, and minerals, and must be managed properly. Spent grain is a by-product with high moisture, high protein and high fiber content and is susceptible to microbial contamination; thus, a suitable, cost-effective, and environmentally friendly valorization method of processing it is required. This by-product is used as a raw material in the production of many other food products—bakery products, pasta, cookies, muffins, wafers, snacks, yogurt or plant-based yogurt alternatives, Frankfurter sausages or fruit beverages—due to its nutritional values. The circular economy is built on waste reduction and the reuse of by-products, which find opportunities in the regeneration and recycling of waste materials and energy that become inputs in other processes and food products. Waste disposal in the food industry has become a major issue in recent years when attempting to maintain hygiene standards and avoid soil, air and water contamination. Fortifying food products with spent grain follows the precepts of the circular bio-economy and industrial symbiosis of strengthening sustainable development. The purpose of this review is to update information on the addition of spent grain to various foods and the influence of spent grain on these foods.
NH2-MIL-125(Ti)/Reduced Graphene Oxide Enhanced Electrochemical Detection of Fenitrothion in Agricultural Products
Authors: Shu Zaixi , Zou Yue , Wu Xuyue , Zhang Qi , Shen Yafang , Xiao Anhong , Duan Shuo , Pi Fuwei , Liu Xiaodan , Wang Jiahua , Dai Huang
Published: April 2023

The abuse of organophosphate pesticides causes serious threats to human health, which threatens approximately 3 million people and leads to more than 2000 deaths each year. Therefore, it is necessary to determine the residue of fenitrothion (FT) in environmental and food samples. Herein, we developed a non-enzymatic electrochemical sensor with differential pulse voltammetry signal output to determine FT in model solutions and spiked samples. Delicately, the sensor was designed based on the fabrication of hydrothermally synthesized titanium-based metal-organic frameworks (MOFs) material (NH2-MIL-125(Ti))/reduced graphene oxide (RGO) (NH2-MIL-125(Ti)/RGO) nanocomposites for better target enrichment and electron transfer. The peak response of differential pulse voltammetry for FT under optimized conditions was linear in the range of 0.072–18 μM with the logarithm of concentrations, and the detection limit was 0.0338 μM. The fabricated sensor also demonstrated high stability and reproducibility. Moreover, it exhibited excellent sensing performances for FT in spiked agricultural products. The convenient fabrication method of NH2-MIL-125(Ti)/RGO opens up a new approach for the rational design of non-enzymatic detection methods for pesticides.
How to Effectively Reduce Honey Adulteration in China: An Analysis Based on Evolutionary Game Theory
Authors: Zhang Xiao-Wei , Xu Letian , Wang Si-Yi , Wang Lin , Dunn Derek W. , Yu Xiaoping , Ye Xinping
Published: April 2023

Apiculture has been greatly developed in recent years in China. Beekeeping cooperatives and honey manufacturing enterprises have increased rapidly. As a result, a variety of honey products have entered the market, adding vitality to the food economy; however, the adulteration of honey products is on the rise in China. Previous attempts to control the adulteration of honey products mostly relied on technical, product-specific measures, and there was a lack of modeling research to guide the supervision of the honey product industry. In order to help local governments to better control the adulteration of honey products from a management perspective, this paper establishes an evolutionary game model composed of beekeeping cooperatives, honey product enterprises, and local governments. Through stability analysis and model simulation, we found that local government subsidies to cooperatives have little impact on the game system. Local government penalties to cooperatives and price adjustments of unadulterated raw honey by cooperatives are effective management tools to reduce the adulteration behavior of cooperatives. Local government penalties for enterprises are an effective management tool to reduce the adulteration behavior of enterprises. This research provides useful information for government agencies to design appropriate policies/business modes so as to promote sustainability and the healthy development of the honey product industry in China.
The Possibility of Using Sulphur Shelf Fungus (Laetiporus sulphureus) in the Food Industry and in Medicine—A Review
Authors: Adamska Iwona
Published: April 2023

Sulphur shelf fungus (Laetiporus sulphureus) has so far been largely underestimated as a potential raw material for the food industry. Many studies have demonstrated that the extracts obtained from this mushroom and some of their components have positive effects on human health. They have antioxidant, antibacterial, and anticancer properties and regulate human metabolism and digestive processes. Water extracts also have this effect. In addition, the substances contained in this mushroom have the ability to preserve food by inhibiting the growth of undesirable microorganisms. These properties have led to the situation that in some countries, shelf sulphur fungus is legally recognized as a raw material that meets the requirements of the food and processing industries. This paper is a review of the latest information (mainly for the period 2016–2023) on the chemical composition and the possibility of using L. sulphureus in the food industry and in medicine.
Earthquake, Fire, and Water: Destruction Sequence Identified in an 8th Century Early Islamic Harbor Warehouse in Caesarea, Israel
Authors: Everhardt Charles J. , Dey Hendrik W. , ‘Ad Uzi , Sharvit Jacob , Gendelman Peter , Roskin Joel , Robins Lotem , Jaijel Roy , Barkai Ofra , Goodman-Tchernov Beverly N.
Published: April 2023

An 8th century CE earthquake severely damaged inland cities across the southern-central Levant, but reported evidence of this earthquake along the coastline is scarce. In Caesarea Maritima, archaeologists have found contemporaneous anomalous sand and shelly layers within nearshore structures and interpreted them as construction fill, aeolian accumulation, or abandonment debris. Recently, similar sand deposits were exposed in a Roman-to-Islamic harbor-side warehouse. This presented the first opportunity to directly sample and systematically analyze in situ, undisturbed deposits in order to determine their origin and taphonomic (source and transport) history. Two sediment cores from the deposit as well as comparative reference samples from defined contexts were analyzed for grain size distribution, foraminifera (abundance/taphonomy), and relative age (POSL, archaeochronology). The results support the interpretation that the deposit was formed from the transport of offshore marine sediments during a high-energy inundation event, most likely a tsunami associated with the 749 CE earthquake.
Efforts of a Mobile Geriatric Team from a Next-of-Kin Perspective: A Phenomenographic Study
Authors: Larsson Kjerstin , Wallroth Veronika , Schröder Agneta
Published: April 2023

Many older adults with complex illnesses are today cared for by their next of kin in their own homes and are often sent between different caregivers in public healthcare. Mobile Geriatric Teams (MGTs) are a healthcare initiative for older adults with extensive care needs living at home, coordinated between hospital, primary, and municipal care. The study aims to describe how next of kin experience care efforts from an MGT for their older adult family members. The study has a descriptive qualitative design and uses a phenomenographic approach. Fourteen next of kin to older adult family members who receive efforts from an MGT were interviewed. Two descriptive categories reflecting their experiences emerged: Professional care and No longer having the main responsibility. The study shows that the participants valued that the staff was very competent, that the physician made home visits and could make quick decisions, and that treatments were given at home. They feel that they receive support and experience security and that a burden is lifted from them. Our study shows that through the MGT, next of kin become involved in the care and are relieved of the burden of responsibility of caring for their older family member.
Identifying the Barriers to Universal Cervical Length Screening for Preterm Birth Prevention at a Tertiary Hospital in Thailand (Physician Perspectives): Implementation Research
Authors: Chawanpaiboon Saifon , Titapant Vitaya , Anuwutnavin Sanitra , Kanjanapongporn Attapol , Pooliam Julaporn
Published: April 2023

Objective: To identify physicians’ views on the barriers to measuring cervical length for preventing preterm deliveries. Materials and methods: This prospective, descriptive implementation study had three phases. In Phase I, 20 physicians were interviewed. Phase II comprised questionnaire development and data validation. The questionnaire was distributed to 120 Phase III participants. Results and discussion: All 120 participants responded. In 44 cases, the physicians received support from their local Maternal and Child Health Boards for preterm-birth-prevention programs; the other 76 physicians did not. The doctors tended to believe that cervical length screening plays no role in preventing preterm births (4/44 (9.1%) and 24/76 (31.6%); OR, 4.615; 95% CI, 1.482–14.373; p = 0.005). They were unsure about the correct measurement procedures (13/44 (29.5%) and 37/76 (48.7%); OR, 2.262; 95% CI, 1.028–4.977; p = 0.040). A lack of cost-free drug support (progesterone) for women with short cervices was identified as a barrier to preventing preterm births (30/44 (68.2%) and 32/76 (42.1%); OR, 0.339; 95% CI, 0.155–0.741; p = 0.006). Conclusions: Many physicians are unconvinced that measuring cervical length prevents premature births, and are unsure about the correct measurement procedures. There is a lack of government funding for hormone-usage programs.
AutoML with Bayesian Optimizations for Big Data Management
Authors: Karras Aristeidis , Karras Christos , Schizas Nikolaos , Avlonitis Markos , Sioutas Spyros
Published: April 2023

The field of automated machine learning (AutoML) has gained significant attention in recent years due to its ability to automate the process of building and optimizing machine learning models. However, the increasing amount of big data being generated has presented new challenges for AutoML systems in terms of big data management. In this paper, we introduce Fabolas and learning curve extrapolation as two methods for accelerating hyperparameter optimization. Four methods for quickening training were presented including Bag of Little Bootstraps, k-means clustering for Support Vector Machines, subsample size selection for gradient descent, and subsampling for logistic regression. Additionally, we also discuss the use of Markov Chain Monte Carlo (MCMC) methods and other stochastic optimization techniques to improve the efficiency of AutoML systems in managing big data. These methods enhance various facets of the training process, making it feasible to combine them in diverse ways to gain further speedups. We review several combinations that have potential and provide a comprehensive understanding of the current state of AutoML and its potential for managing big data in various industries. Furthermore, we also mention the importance of parallel computing and distributed systems to improve the scalability of the AutoML systems while working with big data.
Investigations of Ratio-Based Integrated Influence Lines as Features for Bridge-Damage Detection
Authors: Döring Andreas , Vogelbacher Markus , Schneider Oliver , Müller Jacob , Hinz Stefan , Matthes Jörg
Published: April 2023

Prestressed concrete bridges built between 1960 and 1990 no longer meet today’s requirements due to loads and increasing mileage of higher loads that have increased since the bridges were designed. Prestressed concrete bridges are representative of Germany’s existing bridges. In order to deal with the large number of ageing bridges, recalculations and measurements for control as well as bridge monitoring are an important means of support. For both, it is important to find features that are damage-sensitive as well as robust against measurement noise, vehicle parameters (dynamics, geometry, weight, etc.) and environmental influences (temperature, wind, etc.). In this paper, we present features for damage detection based on the influence line, which are investigated with respect to the above requirements by using the analytical solution of the Euler–Bernoulli beam and more complex numerical bridge simulations. In this context, we restrict ourselves to the damage caused by bending stress. The features are calculated on the basis of single vehicle crossings over the bridge for the strain in the longitudinal direction as well as for the deflection of the bridge at different sensor positions. The ratio-based features are compared with raw data and natural frequencies in a classification. Additionally, the sensor positioning is considered. The investigations shows that the ratio-based integrated influence lines are equivalent to or better than the modal parameters, especially when noise and temperature changes are taken into account.
Efficacy of Commercially Available Entomopathogenic Agents against the Polyphagous Shot Hole Borer in South Africa
Authors: Nel Wilma J. , Slippers Bernard , Wingfield Michael J. , Yilmaz Neriman , Hurley Brett P.
Published: April 2023

The invasive ambrosia beetle, Euwallacea fornicatus, was first reported in South Africa in 2018. The beetle has now spread to eight provinces of the country and has had a devastating impact on both native and non-native tree species. This is especially true for trees located in urban and peri-urban environments. Recent predictions are that the South African E. fornicatus invasion will cost an estimated ZAR 275 billion (approx. USD 16 billion) if it continues to spread uncontrollably, justifying an urgent need for its effective management in the country. One option is biological control, which is preferred over the use of chemicals due to its lower environmental impact. We tested two broad-spectrum fungal entomopathogenic agents, Eco-Bb® and Bio-Insek, which are commercially available in South Africa, for efficacy against E. fornicatus. Initial laboratory assays yielded promising results. However, beetle infestation trials using treated pieces of woody castor bean stems showed little effect on beetle survival and reproduction.
Early and Mid-Term Outcomes of Transcatheter Aortic Valve Implantation versus Surgical Aortic Valve Replacement: Updated Systematic Review and Meta-Analysis
Authors: Lerman Tsahi T. , Levi Amos , Talmor-Barkan Yeela , Kornowski Ran
Published: April 2023

(1) Background: The use of transcatheter aortic valve implantation (TAVI) for the treatment of severe symptomatic aortic stenosis is expanding significantly. We aimed to perform a meta-analysis comparing the safety and efficacy of TAVI versus surgical aortic valve replacement (SAVR) during the early and mid-term follow-up period. (2) Methods: We conducted a meta-analysis of randomized controlled trials (RCTs) comparing 1- to 2-year outcomes between TAVI and SAVR. The study protocol was preregistered in PROSPERO and the results were reported according to PRISMA guidelines. (3) Results: The pooled analysis included data from eight RCTs totaling 8780 patients. TAVI was associated with a lower risk of all-cause mortality or disabling stroke (OR 0.87, 95%CI 0.77–0.99), significant bleeding (OR 0.38, 95%CI 0.25–0.59), acute kidney injury (AKI; OR 0.53, 95%CI 0.40–0.69) and atrial fibrillation (OR 0.28, 95%CI 0.19–0.43). SAVR was associated with a lower risk of major vascular complication (MVC; OR 1.99, 95%CI 1.29–3.07) as well as permanent pacemaker implantation (PPI; OR 2.28, 95%CI 1.45–3.57). (3) Conclusions: TAVI compared with SAVR during early and mid-term follow-up was associated with a lower risk of all-cause mortality or disabling stroke, significant bleeding, AKI and atrial fibrillation; however, it was associated with a higher risk of MVC and PPI.
Kinesio Taping as an Adjunct Therapy in Postoperative Care after Extraction of Impacted Third Lower Molars—A Randomized Pilot Study
Authors: Pławecki Piotr , Pierwocha Karolina , Terlecki Wojciech , Kawulok Anna , Bogacz Mateusz , Balicz Agnieszka , Jędrusik-Pawłowska Magdalena , Dąbrowska-Galas Magdalena , Morawiec Tadeusz
Published: April 2023

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly administered according to protocol for the management of complications such as pain, swelling, and trismus following the removal of the third impacted lower molar; however, treatment with NSAIDs may result in multiple adverse effects. The aim of this study was to compare the effectiveness of kinesio taping (KT) and the use of NSAIDs in the treatment of postoperative complications after extraction of an impacted third lower molar. Material and methods: The study comprised a group of 30 patients, randomly divided into the test group (with KT, n = 15) or the control group (without KT, n = 15). The surgery was performed according to standard procedures. In the test group, KT was applied immediately after surgery. Pain, swelling, and trismus were assessed. The VAS scale was used to assess pain. Swelling was measured based on six reference points on the face using a tailor’s meter, and a caliper was used to measure the distance between the upper and lower medial incisors of the upper and lower teeth to determine the extent of trismus. Measurements were performed three times: on the day of the surgery, on the second day following the surgery, and on the 7th day after the surgery. Results: Pain intensity (day of procedures), maximum mouth opening (on the seventh day after the surgery), and the use of NSAIDs (day of surgery) were significantly lower (p < 0.05) in the test group than in the control group. Conclusions: Kinesio taping in addition to NSAIDs was found to be more effective than NSAIDs alone in increasing the degree of jaw opening, decreasing pain intensity, and reducing the non-steroid anti-inflammatory dosage in patients after impacted mandibular wisdom teeth surgery.
SGLT2 Inhibitors: Statins or ACE-Inhibitors of the 21st Century?
Authors: Correale Michele , Tricarico Lucia , Iacoviello Massimo , Brunetti Natale Daniele
Published: April 2023

Current guidelines propose therapeutic algorithms based on left ventricular ejection fraction values and clinical presentations; however, these guidelines do not specify which of the four pillar drugs to start first [...]
Evaluation of the Reduction of Skin Hyperpigmentation Changes under the Influence of a Preparation Containing Kojic Acid Using Hyperspectral Imaging—Preliminary Study
Authors: Wawrzyk-Bochenek Iga , Rahnama Mansur , Stachura Martyna , Wilczyński Sławomir , Wawrzyk Anna
Published: April 2023

Aim: The aim of this study was to demonstrate the effects of using a preparation containing kojic acid on skin hyperpigmentation using hyperspectral imaging, which enables a quantitative assessment of the effect of the preparation used on the reduction of skin discoloration. Materials and methods: Preliminary studies were carried out on 12 patients with post-acne skin. A hyperspectral camera with a spectral range of 400–1000 nm was used to image skin hyperpigmentation before and after the application of 3% kojic acid. Hyperspectral profiles were analyzed, and image analysis and processing methods were applied. Results: Studies performed using a hyperspectral camera have shown that kojic acid reduces skin discoloration by increasing skin brightness in 75% of patients tested, reducing skin contrast in approximately 83% and increasing skin homogeneity in approximately 67% of patients.
Do Highly Trained Mountain Runners Differ from Recreational Active Non-Runners on Range of Motion and Strength in the Hip and Ankle as Well as Postural Control?
Authors: Zając Bartosz , Olszewski Maciej , Mika Anna , Maciejczyk Marcin
Published: April 2023

The rules governing mountain running force athletes to implement into their training programmes uphill and downhill running on unstable surfaces, which are demanding for hip and ankle as well as for the postural control system. The aim of the present cross-sectional study was to compare highly trained mountain runners (MR) and recreational active non-runners (NR) on range of motion (ROM) and strength in the hip and ankle, as well as dynamic postural control. Thirty MR and thirty-two NR were included in the study. ROM was assessed using a digital inclinometer. Strength was measured using a hand-held dynamometer. Postural control was evaluated using the lower quarter Y-balance test (YBT-LQ). The results showed that MR, in relation to NR, had statistically significant smaller hip external rotation ROM (p = 0.007), lower hip external rotator (p = 0.006) and extensor (p = 0.023) strength and greater normalised anterior reach in the YBT-LQ (p = 0.028). Mountain running training may reduce hip external rotation ROM as well as hip external rotator and extensor strength. Moreover, such training may improve postural control. MR should implement exercises targeted at developing hip ROM and strength. Furthermore, it seems that mountain running training may be a good way to improve postural control.
Family and Spousal Support Are Associated with Higher Levels of Maternal Functioning in a Study of Iranian Postpartum Women
Authors: Ahmadpour Parivash , Curry Carolann , Jahanfar Shayesteh , Nikanfar Rogaiyeh , Mirghafourvand Mojgan
Published: April 2023

Postpartum maternal functioning is a multidimensional concept defined as how a woman manages her daily activities and emotional health after giving birth. This study aimed to determine the predictors of postpartum maternal functioning. This cross-sectional study was conducted on 564 women within one to four months after giving birth (with registered medical records in health centers of Tabriz, Iran) from 2020–2021. The participants were selected based on the cluster sampling method, and data were collected using a standard questionnaire inclusive of sociodemographic and obstetric characteristics, obstetric history, and Barkin Index of Maternal Functioning (BIMF). The adjusted general linear model was employed to estimate the effect of each independent variable (sociodemographic and obstetric characteristics) on the dependent variable (maternal functioning). The mean total score of maternal functioning was 93.1 (±SD = 14.8) out of 120. Based on the adjusted generalized linear model (GLM), “spouse support” and “family support” were strong predictors of maternal functioning. The total score of maternal functioning in women with moderate (B: −4.44; 95% CI: −7.71 to −1.17; p < 0.001) and low (B: −4.77; 95% CI: −8.90 to −1.47; p < 0.001) spousal support was significantly lower compared to women who received a high level of spousal support. Additionally, this score in women with moderate (B: −5.22; 95% CI: −8.56 to −1.87; p < 0.001) and low (B: −3.90; 95% CI: −7.31 to −0.48; p < 0.001) family support was significantly lower compared to women who received a high level of family support. Study results suggest that receiving support from both a spouse and family members can improve maternal functioning.
A Novel Approach for Enhanced Osteosarcoma Photodynamic Therapy Using Encapsulated Methylene Blue in Silica Nanoparticles
Authors: Al Jarrah Khaled , Al-Akhras M-Ali H. , Makhadmeh Ghaseb N. , AlZoubi Tariq , Abuelsamen Abdulsalam , Zyoud Samer H. , Mhareb Mohammad A. , Aziz Azlan Abdul , Abu Noqta Osama
Published: April 2023

Photodynamic therapy (PDT) is a cutting-edge cancer treatment that utilizes both light and photosensitizers (PSs) to attack cancer cells. Methylene blue (MB) has emerged as a highly promising photosensitizer (PS) in PDT therapy due to its exceptional ability to produce singlet oxygen, which is attributed to its high quantum yield. However, the main challenge in utilizing MB in photodynamic therapy is its effective delivery to the target tissue. This challenge can be addressed by utilizing silica nanoparticles (SiNPs) as a drug delivery agent. Silica nanoparticles encapsulate MB and prevent its leakage, offering a novel approach to improving PDT therapy by reducing the toxicity of MB and increasing its bioavailability at the target cell. In this study, an extensive analysis of the size and shape evolution of the synthesized silica nanoparticles loaded with MB was conducted using TEM. Various encapsulated and bare MB concentrations were tested for cytotoxicity against osteosarcoma cells. Moreover, the optimal concentration and exposure time under light (with an intensity of approximately 8.9 mW/cm2 in the visible range) were determined to achieve maximum cell elimination. The results revealed that encapsulated MB in SiNPs exhibited a higher efficacy compared to naked MB, with a 50% increase in concentration effectiveness and a 90% increase in exposure time efficacy. This confirms that encapsulated MB in SiNPs is more effective in killing osteosarcoma cells than bare MB, thereby enhancing photodynamic therapy through increased bioavailability of MB in target cells. The enhanced bioavailability of MB in target cells as a result of its encapsulation in SiNPs makes it a highly promising drug delivery candidate for significantly enhancing the efficacy of photodynamic therapy against osteosarcomas.
Selecting Normalizers for MicroRNA RT-qPCR Expression Analysis in Murine Preimplantation Embryos and the Associated Conditioned Culture Media
Authors: Hawke David C. , Watson Andrew J. , Betts Dean H.
Published: April 2023

Normalizing RT-qPCR miRNA datasets that encompass numerous preimplantation embryo stages requires the identification of miRNAs that may be used as stable reference genes. A need has also arisen for the normalization of the accompanying conditioned culture media as extracellular miRNAs may serve as biomarkers of embryo developmental competence. Here, we evaluate the stability of six commonly used miRNA normalization candidates, as well as small nuclear U6, using five different means of evaluation (BestKeeper, NormFinder, geNorm, the comparative Delta Ct method and RefFinder comprehensive analysis) to assess their stability throughout murine preimplantation embryo development from the oocyte to the late blastocyst stages, both in whole embryos and the associated conditioned culture media. In descending order of effectiveness, miR-16, miR-191 and miR-106 were identified as the most stable individual reference miRNAs for developing whole CD1 murine preimplantation embryos, while miR-16, miR-106 and miR-103 were ideal for the conditioned culture media. Notably, the widely used U6 reference was among the least appropriate for normalizing both whole embryo and conditioned media miRNA datasets. Incorporating multiple reference miRNAs into the normalization basis via a geometric mean was deemed beneficial, and combinations of each set of stable miRNAs are further recommended, pending validation on a per experiment basis.
Hybrid Modeling of Persistent Shoreline Oil Residues on Abu Ali Island, Saudi Arabia: Extent, Degree, and Remediation Implications
Authors: Nixon Zachary , Michel Jacqueline , Zengel Scott , Cotsapas Linos , Fravel Harold , Weaver Jennifer , Bambach Philip
Published: April 2023

Extensive intertidal asphalt pavements and oiled sediment accumulations extend more than 20 km along the northern shoreline of Abu Ali Island, located north of Jubail on the Arabian (Persian) Gulf coast of Saudi Arabia. This shoreline oiling likely originated from two platforms in the Nowruz oil field, which spilled oil from 1983 to 1985; this was one of the largest marine spills in history, with shoreline impacts that were little known. In this study, we used a novel methodology that combined remote sensing analyses with hybrid machine learning–geostatistical modeling of field-collected data to quantify the distribution, extent, and volume of these contaminated sediments to investigate the mechanisms for their persistence and to support the development of remediation plans. After nearly 40 years, approximately 25,000 m3 of contaminated sediments remain, with nearly 50% of these buried underneath clean sediments. The presence of exposed or subsurface carbonate beach rock platforms or ramps clearly influences the ongoing persistence of these asphalt pavements by protecting them from physical energy and sediment mobilization. These rock platforms complicate potential remediation options, with more than 66% of the modeled volume of asphalt pavement estimated to be directly on top of and in contact with carbonate beach rock. The asphalt pavements present persistent ongoing PAH toxicity and continually shed smaller fragments when exposed to wave energy along with localized sheens and liquid oil, presenting a pathway for ongoing chronic exposure of biota.
Investigation on Load Characteristics of Hinged Connector for a Large Floating Structure Model under Wave Actions
Authors: Song Xuemin , Liu Weiqin , Wu Hao
Published: April 2023

The super-large floating bodies are often designed as multimodule structures linked by connectors, and the load and strength evaluation of the connector structure becomes an essential work in the design procedure of these floating bodies. In this paper, the hydrodynamic experimental model of a double floating body with a hinged connecter is designed first, and a hinged connector is adopted for connecting the double module floating bodies. A test is conducted for load calibration. Then, the experiments are carried out in the towing tank under different wave conditions. The load characteristics of the hinged connector are measured in the experiment. The numerical simulations for the load of the hinged connector are conducted based on the commercial platform ANSYS. The time history of the vertical, lateral and longitudinal loads for the hinged connector are illustrated. Finally, the comparison and analysis between the experimental results and numerical results is presented, and the conclusions are drawn, which indicate that the numerical method is effective to predict the load characteristics of a hinged connector. Above all, the methods and conclusions of this study are used to provide reference and guidance for the structural design of hinged connectors for floating bodies.
Insight into the Antifungal Effects of Propolis and Carnosic Acid—Extension to the Pathogenic Yeast Candida glabrata: New Propolis Fractionation and Potential Synergistic Applications
Authors: Argüelles Alejandra , Sánchez-Fresneda Ruth , Guirao-Abad José P. , Lozano José Antonio , Solano Francisco , Argüelles Juan-Carlos
Published: April 2023

Fungi have traditionally been considered opportunistic pathogens in primary infections caused by virulent bacteria, protozoan, or viruses. Consequently, antimycotic chemotherapy is clearly less developed in comparison to its bacterial counterpart. Currently, the three main families of antifungals (polyenes, echinocandins, and azoles) are not sufficient to control the enormous increase in life-threatening fungal infections recorded in recent decades. Natural substances harvested from plants have traditionally been utilized as a successful alternative. After a wide screening of natural agents, we have recently obtained promising results with distinct formulations of carnosic acid and propolis on the prevalent fungal pathogens Candida albicans and Cryptococcus neoformans. Here, we extended their use to the treatment against the emerging pathogenic yeast Candida glabrata, which displayed lower susceptibility in comparison to the fungi mentioned above. Taking into account the moderate antifungal activity of both natural agents, the antifungal value of these combinations has been improved through the obtention of the hydroethanolic fractions of propolis. In addition, we have demonstrated the potential clinical application of new therapeutical designs based on sequential pre-treatments with carnosic/propolis mixtures, followed by exposure to amphotericin B. This approach increased the toxic effect induced by this polyene.
Fusarium mindanaoense sp. nov., a New Fusarium Wilt Pathogen of Cavendish Banana from the Philippines Belonging to the F. fujikuroi Species Complex
Authors: Nozawa Shunsuke , Seto Yosuke , Takata Yoshiki , Narreto Lalaine Albano , Valle Reynaldo R. , Okui Keiju , Taida Shigeya , Alvindia Dionisio G. , Reyes Renato G. , Watanabe Kyoko
Published: April 2023

The pathogen causing Fusarium wilt in banana is reported to be Fusarium oxysporum f. sp. cubense (FOC). In 2019, wilt symptoms in banana plants (cultivar: Cavendish) in the Philippines were detected, i.e., the yellowing of the leaves and discoloration of the pseudostem and vascular tissue. The fungus isolated from the vascular tissue was found to be pathogenic to Cavendish bananas and was identified as a new species, F. mindanaoense, belonging to the F. fujikuroi species complex (FFSC); species classification was assessed using molecular phylogenetic analyses based on the tef1, tub2, cmdA, rpb1, and rpb2 genes and morphological analyses. A reciprocal blast search using genomic data revealed that this fungus exclusively included the Secreted in Xylem 6 (SIX6) gene among the SIX homologs related to pathogenicity; it exhibited a highly conserved amino acid sequence compared with that of species in the FFSC, but not with that of FOC. This was the first report of Fusarium wilt in Cavendish bananas caused by a species of the genus Fusarium other than those in the F. oxysporum species complex.
Evaluation of Thermography as a Diagnostic Technique in Asymptomatic or Incipient Onychomycosis
Authors: Villar Rodríguez Julia , Pérez Pico Ana María , García Blázquez Francisco Manuel , Morán Cortés Juan Francisco , Mayordomo Acevedo Raquel
Published: April 2023

Onychomycosis is usually diagnosed symptomatically due to the very clear signs caused by the fungus on the nail surface and structure, although the growth of the infecting agent must also be verified by culture in an enriched medium. This procedure is normally lengthy (four weeks), and samples can be contaminated, delaying the prescription of appropriate and effective treatment. Only one previous study has addressed the possibility of using thermography as a diagnostic method for onychomycosis in older people (31–70 years). The present study confirms this use but in individuals aged 18–31 years with incipient mycosis and no pathological signs. Using an FLIR E60 BX camera in a study with 214 samples, we found that men had more onychomycosis than women. We observed a relation between the presence of infection and nail temperature, with a higher temperature in yeast infections (+1 °C) and a lower temperature in dermatophyte infections (−2 °C). A higher temperature by almost 1 °C was also observed in older participants. Thermography can be viewed as a new diagnostic method in asymptomatic or incipient onychomycosis, providing the thermographic camera is sufficiently sensitive and the appropriate procedure is followed, although fungal culture is always necessary to confirm recovery after treatment.