bluuebunny/crossref_metadata_2025 huggingface dataset:
New perspectives on oral antidiabetics therapy
Authors: Meca Andreea-Daniela , Tarțău Liliana Mititelu , Popa Eliza Grațiela , Gafițanu Carmen , Crețeanu Andreea , Bogdan Maria
Published: July 2019

Diabetes mellitus is a chronic disorder, inherited or acquired, characterised by the incapacity of the body to control the levels of blood glucose. The most common initial symptoms of hyperglycemia are: weight loss, lethargy, polyuria, polydipsia, polyphagia. Treated incorrectly, diabetes can lead to blindness, neuropathy, nephropathy, kidney failure and coronary heart disease. In type 2 diabetes mellitus, besides administrating a classic treatment with oral agents, it is very important that the pacients follow a balanced and strict diet and hidrate themselves correctly. New drugs have been approved and introduced in therapy in Europe and USA in the last years, with reduced risks and higher benefits, but with the limitation of high costs. The SGLT-2 inhibitors (ertugliflozin, dapagliflozin, canagliflozin) have an independent action against insulin, therefore they can be associated with other oral agents, aiming to grow the pacients’ compliance, but also the effects of the farmacotherapy. Oral co-administration in fixed combination with DPP-4 inhibitors, such as sitagliptin, saxagliptin and not only reduces blood glucose, but it will also mutual reduce renal, pancreatic and cardiovascular side effects.
Vitamins and tuberculosis
Authors: Bacinschi Nicolae , Alexandru Sofia , Donica Anna , Guţu Ina
Published: July 2019

The importance of vitamins to the development, progression and treatment of tuberculosis is indisputable due to the presence of hypovitaminosis in people with malnutrition or the increase of vitamin deficiency in the setting of the disease. It was established that vitamin preparations exhibit antimicrobial activity, potentiate efficacy and reduce the toxicity of antituberculous drugs. Recent studies have proved the role of vitamins in the metabolism and multiplication of mycobacteria, suggesting the possibility of developing antitubercular compounds based on vitamin preparations with new mechanisms of action. These data are important for the possibility of combating resistance and multidrug resistance in Mycobacterium tuberculosis.
Mechanistic Insights into Fe Catalyzed α-C-H Oxidations of Tertiary Amines
Authors: Legacy Christopher J. , Greenaway Frederick T. , Emmert Marion
Published: July 2019

We report detailed mechanistic investigations of an iron-based catalyst system, which allows the α-C-H oxidation of a wide variety of amines, including acyclic tertiary aliphatic amines, to afford dealkylated or amide products. In contrast to other catalysts that affect α-C-H oxidations of tertiary amines, the system under investigation employs exclusively peroxy esters as oxidants. More common oxidants (e.g. tBuOOH) previously reported to affect amine oxidations via free radical pathways do not provide amine α-C-H oxidation products in combination with the herein described catalyst system. Motivated by this difference in reactivity to more common free radical systems, the investigations described herein employ initial rate kinetics, kinetic profiling, Eyring studies, kinetic isotope effect studies, Hammett studies, ligand coordination studies, and EPR studies to shed light on the Fe catalyst system. The obtained data suggest that the catalytic mechanism proceeds through C-H abstraction at a coordinated substrate molecule. This rate-determining step occurs either at an Fe(IV) oxo pathway or a 2-electron pathway at a Fe(II) intermediate with bound oxidant. We further show via kinetic profiling and EPR studies that catalyst activation follows a radical pathway, which is initiated by hydrolysis of PhCO3 tBu to tBuOOH in the reaction mixture. Overall, the obtained mechanistic data support a non-classical, Fe catalyzed pathway that requires substrate binding, thus inducing selectivity for α-C-H functionalization.
Global Aromaticity and Antiaromaticity in Porphyrin Nanoring Anions
Authors: Peeks Martin D. , Jirasek Michael , D. W. Claridge Timothy , Anderson Harry L.
Published: July 2019

Doping, through oxidation or reduction, is often used to modify the properties of π-conjugated oligomers. In most cases, the resulting charge distribution is difficult to determine. If the oligomer is cyclic and doping establishes global aromaticity or antiaromaticity, then it is certain that the charge is fully delocalized over the entire perimeter of the ring. Here we show that reduction of a six-porphyrin nanoring using decamethylcobaltocene results in global aromaticity (in the 6– state; [90 π]) and antiaromaticity (in the 4– state; [88 π]), consistent with Hückel’s rules. Aromaticity is assigned by NMR spectroscopy and density-functional theory calculations.
Optimized Mapping of Gas-Phase Quantum Calculations to General Force Field Lennard-Jones Parameters Based on Liquid-State Data
Authors: Kantonen Sophie , Muddana Hari S. , Henriksen Niel M. , Wang Lee-Ping , Gilson Michael
Published: July 2019

We utilize a previously described Minimal Basis Iterative Stockholder (MBIS) method to carry out an atoms-in-molecules partitioning of electron densities. Information from these atomic densities is then mapped to Lennard-Jones parameters using a set of mapping parameters much smaller than the typical number of atom types in a force field. This approach is advantageous in two ways: it eliminates atom types by allowing each atom to have unique Lennard-Jones parameters, and it greatly reduces the number of parameters to be optimized. We show that this approach yields results comparable to those obtained with the typed GAFF force field, even when trained on a relatively small amount of experimental data.
Visualized Spontaneous Molecular Directed Motion in Solid State
Authors: Liu Jianxun , Xing Chang , Wei Donghui , Yang Cuiping , Peng Qiuchen , Hou Hongwei , Li Yuanyuan , Li Kai
Published: July 2019

The real-time monitoring of spontaneous molecular directed motion is a highly important but very challenging task. In this work, a rod-like aggregation-induced emission (AIE) molecule of salicylaldehyde 4-butoxyaniline Schiff base (SBA) was deliberately designed and facilely synthesized, which exhibits unique self-recovery property from semi-ordered structure to ordered structure alongwith significant fluorescence change after grinding. The monitoring of the fluorescence change provides rich kinetic information including kinetic order, rate constants, half-life and apparent activation energy of the spontaneous molecular directed motion process. Unlike instrumental analytical methods such as PXRD and AFM, which only give the information of a stable state of samples, the fluorescence method provided a new perspective to real-time visualize spontaneous molecular directed motion in situ in solid state.
Sortase-Modified Cholera Toxoids Show Specific Golgi Localization
Authors: Machin Darren , Williamson Daniel , Fisher Peter , miller victoria , Wildsmith Gemma , Ross James , Wasson Christopher , MacDonald Andrew , Andrews Benjamin I. , Ungar Daniel , Turnbull W. Bruce , Webb Michael
Published: July 2019

Cholera toxoid is an established tool for use in cellular tracing in neuroscience and cell biology. We use a sortase-labelling approach to generate site-specifically N-terminally modified variants of both the A2-B5 heterohexamer and B5 pentamer forms of the toxoid. Both forms of the toxoid are endocytosed by GM1-positive mammalian cells, and while the heterohexameric toxoid was principally localized in the ER, the B5 pentamer showed an unexpected localization in the medial/trans Golgi. This study suggests a future role for specifically-labelled cholera toxoids in live-cell imaging beyond their current applications in neuronal tracing and labelling of lipid-rafts in fixed cells.
Interpretation of Hermeneutics and Religious Normativity: Hermeneutic Approach in Scientific Studies in the Islamic World
Authors: Sya'bani Mohammad Ahyan Yusuf
Published: July 2019

The clergy has long used the method of hermeneutics in the 17th century to interpret classical texts in meaning. Because of this, in the study of scientific knowledge, Islam tries to use hermeneutical interpretations to find a definition that can be understood easily by humans. So the need to research the above issues to find formulations and hermeneutic methods in Islamic scholarship that not only consists of the holy book of the Qur'an and al-Hadith as authentic texts but also thoughts, culture, fiqh, theology and fields of science others in Islam. This research method is a study with a type of literature study (literature study) with a philosophical-historical approach â€” data collection techniques with documentation techniques. The results of the survey show that Muslim scholars such as Amin Abdullah try to use the hermeneutic method in Islamic studies to produce scientific assumptions in Islamic studies in the following subjects: First, the nature of knowledge summarized in various studies is not fixed and static, but dynamic. Second, the thinking carried out by the scholars' is the result of the interaction between the text (al-Qur`an and Sunnah) and the social context that surrounds it. Third, full emphasis on the empirical-critical paradigm for conducting religious reviews, including thoughts about the sacredness of the text itself, and the results of that thought is not fixed but always changing.
Pengukuran Tekanan Darah Non-Invasive Tanpa Manset Menggunakan Metode Pulse Transit Time Berbasis Machine Learning Multivariat Regresi
Authors: Susana Ernia
Published: July 2019

Currently used non-invasive blood pressure (NIBP) measurements (oscillometric method) has disadvantages related to pumping cuffs which can cause discomfort for patients due to pressure from pumping cuffs. Â The aim of this study was to measure blood pressure in a non-invasive manner without cuffs with the Pulse Transit Time (PTT) methodbase on machine learning technology.The blood pressure measurement by the PTT method is obtained from the calculation of the distance of the R-ECG wave with the peak signal photoplethysmogram (PPG). The main problem of the PTT method in some previous studies is that the estimation of systolic (SBP) and diastolic (DBP) values is still inaccurate. The blood pressure measurement method in this study used a combination of PTT calculations with machine learning multivariate regression. Therefore expected to obtain a more accurate estimate of systolic (SBP) and diastolic blood pressure (DBP). This study is a laboratory experiment research on 30 healthy volunteers aged 20 Â± 1 years. The measurement of the blood pressure value of the PTT-to-oscillometric method is 5 Â± 5 mmHg. The blood pressure values generated by this PTT method have a p-value for the sequential estimation of SBP and DBP of 0.7374 and 0.0262.
Analisis Determinan Bauran Pemasaran pada Poliklinik Rawat Jalan RSK dr. Rivai Abdullah Palembang
Authors: Wempie A Yosef , Fajar Nur Alam , Idris Haerawati
Published: July 2019

Leprosy Hospital of dr. Rivai Abdullah Palembang in the last 3 (three) years found data on visitors who came to the Outpatient Polyclinic showed a downward trend every year since 2015. This study aims to determine the influence of patient perceptions of the marketing mix to the patientâ€™s loyalty at Outpatient Polyclinic of Leprosy Hospital of dr. Rivai Abdullah Palembang. The study design used a cross-sectional approach, where the population in this study was outpatients in 2017. Data collection using a questionnaire that had previously been tested for validity in 30 respondents on inpatients of RSK. dr. Rivai Abdullah Palembang, samples were taken accidentally as many as 152 respondents in September - October 2018 that met the inclusion and exclusion criteria at Outpatient Polyclinic of RSK of dr. Rivai Abdullah Palembang. Data analysis used chi-square and multiple logistic regression. The results of the study showed that the 7 variables (product, price, promotion, place, people, process and physical evidence) there were 3 variables that were significant relationship with patient loyalty, namely promotion (p-value=0.005, OR=6.491), process (p-value=0,000, OR=8,796), and physical evidence (p-value=0,000, OR=12). While the product (p-value=0.335, OR=4,556), price (p-value=1, OR=0,807), place (p-value=1, OR=0,815), people (p-value=1, OR=0.815) showed there was no significant relationship with patient loyalty. The most dominant variable relationship with outpatient loyalty at Leprosy Hospital of dr. Rivai Abdullah Palembang was a physical evidence variable (OR=19,867, 95% CI 4,010 98,429).Â
Alat Pengolah Air Tanah Menjadi Air Bersih dengan Proses Kombinasi Aerasi-Filtrasi Upflow (Desain Rancang Bangun)
Authors: Trigunarso Sri Indra , Mulyono Rifai Agung , Suprawihadi Riyanto
Published: July 2019

In areas that have not received clean water services, residents usually use well water, river water which sometimes even often the water used does not meet the standards of healthy clean water. To treat well water/ ground water is usually the community. build a processing unit in the form of a sand filter. The problem that is often encountered in treatment is cleaning the filter media. This condition is often difficult for the community to do because it requires time and energy, resulting in the sand filter that is supposed to be operational continuously and finally stops and is not even used at all. To overcome this problem, it can be done by improving the design of water treatment units with a system of combination of aeration and upflow flow filtration. This study is to determine the ability of the tool to improve the quality of shallow groundwater in terms of turbidity, Fe, Mn, color and odor to clean water and saturation point of filtering. Research Design is a "quasi-experiment" in the form of "Time Series Design" using a "pre and post test" design without control. The tool is designed in the form of an application prototype to determine its ability to reduce turbidity, Fe, Mn, color and odor and the length of saturation point. The results showed that iron content before processing 2.12 after processing 2,058. pre-treatment manganese content 0.080 after processing 0.078. Color and smell before color processing and odor after processing are colorless and odorless. Microbiological quality for stool coly before processing week 1 32 after treatment 0, week 2 coly of feces before processing 26 after processing 0 and weeks 3 coly of feces before processing 21 and after processing 0. Length of processing up to saturation point filter media total contact time processing is 30 minutes.
Determinan Anemia Ibu Hamil Trimester II dan III di Indonesia (Analisis Data Riset Kesehatan Dasar)
Authors: Pasmawati Pasmawati , Hatma Ratna Djuwita
Published: July 2019

Anemia in pregnant women affects the occurrence of antepartum hemorrhage, postpartum hemorrhage, infection, obstacle to fetal growth and development, and prematurity. The aim of this study is to determine the determinants of anemia in second and third trimester pregnant women in Indonesia. The study is used secondary data of Basic Health Research year of 2013, a cross-sectional study design. The population of this study is pregnant women who were selected as respondents in the Basic Health Research year of 2013. The sample of this study consisted of 379 pregnant women, with a gestational age of 7-41 weeks. HB levels of pregnant women were examined using a portable Hemocue photometer. Independent variables is collected by interview. To determine the anemia determinant factors of pregnant women using Cox regression analysis. The results of this study show the prevalence of anemia in second and third trimester pregnant women in Indonesia is 41.2%. The factors that become anemia determinants in second and third trimester pregnant women in Indonesia are PR parity 1.42 (95% CI: 1.02-1.97), and ANC PR 1.65 (95% CI: 1.20-2,28). Pregnant women who carry out ANC according to standards can reduce the risk of anemia during pregnancy.
Perilaku Merokok Siswa-Siswi Sekolah Menengah Pertama (SMP) di Wilayah Kerja Puskesmas Sei Agul Medan
Authors: Lubis Sri Novita , Bukit Dhani Syahputra
Published: July 2019

Cigarettes are one of the tobacco products that contain addictive substances and other ingredients that are harmful to health both directly and indirectly. According to RisetKesehatanDasar (Riskesdas), there is a trend in the age of smoking that is increasingly young from year to year. This study aims to describe smoking behavior among students of junior high school in the working area of PuskesmasSeiAgul Medan. This research was a descriptive study with a cross-sectional study. The population of this study was all the male and female students in grade 8 of junior high school. There were a total of 384 samples. Data were collected with a questionnaire. The results showed that the prevalence of ever smoking was 32,6%. The respondents who have smoking habits was 85,6%. The highest number of consumption cigarettes was <1 cigarette per day (72,8%) and the lowest was 11-20 cigarettes per day (1,0%), 76,3% have a family history of smoking, and 58,1% had a smoking friend. A total of 98,2% of respondent have been exposed to cigarette advertisements and 63,3% often see cigarette advertisements. The average pocket money was Rp9.567,57. The average cost that spent on cigarettes wasÂ  Rp 3.473,68.
Efektifitas Sayur Pepaya Muda dan Sayur Daun Kelor terhadap Produksi ASI pada Ibu Post Partum Primipara
Authors: Aliyanto Warjidin , Rosmadewi Rosmadewi
Published: July 2019

Mother's milk (ASI) have a role a very important role in the baby's growth process that starts from the beginning of its birth, so it is expected that breast milk production in postpartum mothers can meet the needs of babies at the beginning of their lives. The problem in this study was that 54% of primipara postpartum mothers had not yet produced breast milk on day 3 or 4. According to Istiqomah et al (2014), Zakaria's research (2016), the papaya fruit and Moringa leaf act as Laktogogum which can increase milk production and facilitate breast milk expenditure. This study aims to determine the effectiveness of consumption of young papaya vegetables and Moringa leaf vegetables on breast milk production in postpartum primipara mothers in the independent practice of midwives in Bandar Lampung City in 2018. The indicators used to determine breast milk production are seen from baby weight gain at 30 days first life. This type of research is quantitative research using the Quasi-experimental design, namely Non-Equivalent Control Group Design. The subjects of the study were 90 primiparous postpartum mothers. Data collection uses primary data. Analysis using the Independent Sample T-Test. The results showed increased breast milk production in primipara postpartum mothers who consumed young papaya vegetables seen from the average increase in baby weight at 30 days at 930 grams and primipara postpartum mothers who consumed kelor leaf vegetables on average baby weight gain 1270 gram. Whereas in primipara postpartum mothers who did not consume young papaya and kelor leaf vegetables, the average increase in body weight of infants aged 30 days were 847 grams. There was a significant difference in breast milk production in primiparous postpartum mothers between those who consumed young papaya vegetables and Moringa leaf vegetables to increase infant weight at 30 days with p-value 0.001. As for effectiveness, consumption of vegetable Moringa leaves is more effective at increasing the baby's weight at 30 days of age compared to consuming young papaya vegetables.Â
Pengaruh Penyuluhan 1000 Hari Pertama Kehidupan (HPK) pada Pasangan Usia Subur di Perkotaan dan Perdesaan
Authors: Al Rahmad Agus Hendra
Published: July 2019

Nutrition improvements in the group of the first 1000 days of life will support the growth process from pregnancy to children aged 2 years. The main factor of nutrition improvement is knowledge about the first 1000 days of life. Nutritional adequacy in the first 1000 days of life affects the lives of infants and children aged 2 years, Aceh province shows 23,7% of Aceh children suffer from malnutrition. Then to increase knowledge, conducted counseling about the first 1000 days of life. The goal is to compare the effectiveness of counseling to increase knowledge of couples of childbearing age in urban and rural areas. Quantitative research designed quasi-experiment. Samples are 100 couples people. The location of the research was conducted in Baiturrahman and Darul Kamal Subdistricts, research was conducted on 26-28 July 2017. Data collection includes primary and secondary data, Then processed through the stages of editing, coding, processing, and cleaning. Data analysis using T-Test. The Results, there is an increasing influence of counseling the first 1000 days of life to couples of childbearing age in urban and rural areas, with p<0,05. Counseling the first 1000 days of life to have better effectiveness in improving knowledge couples of childbearing age, with p<0,05. While the comparison of knowledge, the average score in urban (50) is higher compared with rural (45). Conclusion, counseling the first 1000 days of life take effect to Increased knowledge of couples of childbearing age and have better effectiveness, as well as a higher knowledge increase in urban areas than in rural areas.
Studi Kualitatif: Sumber Self-Efficacy Mobilisasi Pasien selama Perawatan di Rumah Sakit
Authors: Erlina Lina
Published: July 2019

High self-efficacy increases a person's ability to achieve certain targets beyond their actual abilities. The role of self-efficacy on the mobilization ability patient's during hospitalization has been proven. However, the source of self-efficacy of the patient for mobilization is not yet known. This study aimed to know what sources of self-efficacy of the patient for mobilization during hospitalization. This study used a qualitative study in which the data collected through in-depth interviews with 10 patients in the internal medicine room. Eight themes were obtained: 1) Habits of mobilization before illness, 2) Effects that patients feel after mobilizing, 3) Availability of mobilization facilities, 4) The success of other patients mobilizes, 5) verbal expressions directly from other people, 6) Self-statement, 7) Patient's physical condition, 8) Patient's psychological condition. Obtained eight themes of the source self-efficacy of the patient for mobilization during hospitalization, but it is not yet known which source is the most important. Further research is needed to find out the role of mobilization self-efficacy sources towards increasing patient mobilization capabilities.
Kemampuan Sabun Antiseptik Cair yang Mengandung Triclosan yang Terdaftar di BPOM dalam Menghambat Pertumbuhan Bakteri Escherichia coli
Authors: Marhamah Marhamah , Ujiani Sri , Tuntun Maria
Published: July 2019

In the community, there is still circulating hand washing soap containing triclosan and registered with BPOM/Ministry of Health, but the packaging is not printed how many milliliters of water should be added so that the concentration is not effective in killing bacteria on the hand. The purpose of this study was to determine the ability of liquid antiseptic soap containing triclosan registered at BPOM/Ministry of Health in inhibiting the growth of Escherichia coli bacteria and bacteria on the hands. The research was carried out at the Bacteriology Laboratory of the Department of Health Analyst at Tanjungkarang Health Polytechnic and Lampung Veterinary Center in July-November 2017. This type of research was a completely randomized design. Pre-experiment of one group pre-post-test, the test method of Total Plate Numbers (ALT). Test uses concentrations of 2%, 4%, 6%, 8% and 10% with 5 repetitions. The results showed the strength of liquid antiseptic soap containing triclosan with a concentration of 2%, 4%, 6%, 8% and 10% including the criteria of being moderate and effective in killing bacteria on the hand with a decrease in germ number 96.18%. The Anova test obtained p-value 0,000, meaning that there was an effect of the concentration of liquid antiseptic soap on the growth of Escherichia coli bacteria. The LSD test results showed a significant difference between each liquid antiseptic soap concentration (p-value 0,000-0,024) in inhibiting bacterial growth. The results of the T-test showed that there were differences in the number of germs (ALT) in the hands before and after hand washing with liquid antiseptic soap.
Pengaruh Psikoedukasi terhadap Kecemasan Ibu Pre Operasi Kanker Payudara
Authors: Astuti Titi , Desvianti Rizki Azni , Bangsawan Merah
Published: July 2019

International Agency for Research on Cancer (IARC) in 2012, The incidence of cancer in women in Indonesia 134 per 100,000 population with the highest incidence in women is breast cancer of 40 per 100,000. The problem that often arises before surgery is anxiety. The client's anxiety generates a psychosocial response. There is psychological therapy for preoperative patient anxiety treatment with psychoeducation. This study aims to determine the effect of psychoeducation on anxiety levels of patients preoperative breast cancer in RSUD DR. H. Abdul Moeloek Year 2018.Â  Type of quantitative research method using quasi-experiment design with one group pretest design approach posttests design Sampling technique using purposive sampling technique as much as 30 respondents. The time of the study date of May 18, 2018, to June 30, 2018, in the Room of Roses RSUD DR. H. Abdul Moeloek Lampung Province. The data were collected using a self-Rating Anxiety Scale (SAS/ZSRAS) Zung questionnaire. Statistical test using t dependent Wilcoxon.
Perbedaan Skor Nyeri pada Anak dengan Pemberian Madu Setelah Dilakukan Tindakan Pemasangan Infus
Authors: Pebriani Sintiya Halisya , Irwadi Irwadi
Published: July 2019

Intravenous fluid therapy in a child in the emergency room may lead to prolonged trauma and is a procedure that can cause anxiety, fear and uncomfortable pain. Handling of pain in children can be done with non-pharmacological techniques that are by giving a sweet taste of honey, wherein honey contains flavonoid content that can inhibit the pain. The purpose of this study was to know differences in pain scores after the installation of infusion between groups of children given honey and not given honey. The research design used in the form of quasi-experiment with nonequivalent control group type, post-only design, with the number of samples were 34 people who met the inclusion criteria. The sample was divided into two groups: the intervention group who received honey peroral (17 respondents) and the control group who did not get honey peroral (17 respondents), with age of respondent 1-6 years. Pain scores were evaluated with Children's Hospital of the Eastern Ontario Pain Scale (CHEOPS). A statistical test was using Mann-Whitney test with 95% (Î±=0,05 ) incidence rate. The result showed that there was a difference in child pain score in intervention group and control group with p-value=0.000. It can be concluded that there was an effect of giving honey to pain score, wherein the intervention group the pain score was lower than the control group, meaning that honey can reduce the pain response in children.
Non-Invasif Termometer:Temporal Artery Thermometer(TAT) Terintegrasi dengan Electronic Medical Recordsebagai Peringkat Teratas Metode Pengukuran Suhu pada Bayi dan Anak: Kajian Literatur
Authors: Sugiarti Sugiarti
Published: July 2019

Fever in children caused the high use of healthcare facilities. The majority of parents (90%) recognized paracetamol as an antipyretic for children, and only 36.7% of parents who receive the antipyretics were prescribed. Excessive parental concern can lead to aggressive practices harmful to children, such as over dosage of antipyretic use. Accurate temperature assessment was important for early detection of fever, nursing clinical decision, medical diagnosis, and the need for specific laboratory tests. TAT is a new innovation and alternative in the field of child nursing as a detector of fever in children. TAT comes in an automatic form connected to the monitor's vital sign, and integrates with electronic medical records, in order to meet the demanding use of advances in electronic medical records on temperature measurements. Comfort, accuracy, sensitivity, and convenience TAT also carries the concept of nursing atraumatic care and Family Centered Care (FCC). Child nurses in Indonesia need to improve service quality by learning new technologies, and applying existing evidence-based.
Analisis Pengelolaan Trias Usaha Kesehatan Sekolah (UKS) di Tingkat SMP Se-Kota Bandar Lampung (Studi Kualitatif)
Authors: Novariana Nana , Hermawan Nur Sefa Arief
Published: July 2019

School Health Effort Programs held at all levels of education. The purpose of School Health Efforts was to improve the quality of education and learning achievement of learners by improving the behavior of clean and healthy life and health status and create a healthy environment, thus allowing harmonious growth and optimum development in the framework of human formation in Indonesia as a whole. The purpose of this research was to analyze more deeply about the management of Trias School Health Efforts (UKS) at Junior High School level in Bandar Lampung City in 2017. This research was a qualitative research type with descriptive analysis research design with phenomenology approach. The study was conducted from March to April 2017 at the Junior High School level in Bandar Lampung city, the Office of the Ministry of Religious Affairs of Bandar Lampung City, the Bandar Lampung City Health Office, and the Education Office of Bandar Lampung City. With informants, 31 informants from headmasters, UKS teachers, and UKS officers, and staff organizing UKS at Health Office, Education Office, and Ministry of Religious Affairs. The conclusion of the research result was that in general tries of UKS in junior high school level as Bandar Lampung City has been running quite well, both in terms of health education, health service, and healthy environment coaching. It was just that in each of the triads still need more and more coaching. As well as from the Community Health Centres can further channel the new sciences that have been obtained for more fostering schools that exist within the target area.
Visualisasi Matriks Biofilm Eschericia coli dengan Media Bacteriological Peptone, Sucrose dan Ethanol
Authors: Marlina Dwi , Kurniati Mala , Hamid Fauzan , Larasathi Fivi , Irnawita Febtri
Published: July 2019

Escherichia coli is a bacterium which is found in the intestines as a normal flora. In 2011, WHO (World Health Organization) showed that 14% of Children's Deaths that is caused by Escherichia coli. On the other hand, Escherichia colicauses 30-40% incidence of Nosocomial Urinary Tract Infection was associated with the use of urinary catheters. In extreme conditions, Escherichia coli can create biofilms, such as at reduced nutrient conditions, pH 7-7, and temperature 200C - 400C. Biofilm is formed from Escherichia coli that is contained EPS (extracellular polymeric substances). It has function as protector of bacterial cells. EPS contains glucuronic acid and Manosa. The formation of Biofilm can extend treatment process of patients and can cause chronic and recurrent inflammatory process. Aims this study is to know the characteristics of Escherichia coli biofilm and visualize the biofilm produced using sucrose 2%, 5% ethanol and 25% Peptone bacteriological in a culturing process. This study is an experimental and use microorganisms Escherichia coli which is cultured inÂ  Laboratory of Microbiology, University of Lampung and used Scanning Electron Microscope (SEM) for visualization and Aurum (Au) for coating. Based on the findings of observation under SEM (Scanning Electron Microscope), Escherichia coli has a thick layer as a biofilm, particularly in Bacteriological Peptone 25%.Â  Therefore, bacterial cell colonies sheltered perfect from various antibacterial. Conclusion: Escherichia coli perfectly can create biofilms. For advanced research, can find the inhibitor of biofilm and destroyer of Escherichia coli cells.
Analisis Perilaku Pekerja Gondola PT. Waringin Megah Proyek Springhill Condotel Lampung
Authors: Sahli Zamahsjari , Triyanto Triyanto
Published: July 2019

This research was conducted at Springhill Condotel Lampung to find out and dig deeper into the behavior of gondola workers. This study used a qualitative study approach. Information collection and retrieval is obtained through observation, in-depth interviews, and document studies. The supporting factors that have not supported the gondolier workers to behave safely are knowledge of the hazards, the bad perception about Personal Protective Equipment (PPE), and the undisciplined attitude of the workers Using PPE. On the enabling factor, it was found out that the availability of PPE and the existing rules in the project enables gondola workers to behave safely, but still found unsafe acts. And on the reinforcement factor, less supervision was found from supervisors and safety. Company to provide information about hazards of gondolas, tighten the control of PPE, and provide safe behavior training. Gondola workers to ask supervisors and OSH sections on things they do not know, change poor perceptions better about the use of PPE, and to improve negative attitudes in the use of PPE and regulations.
Faktor Risiko yang Berhubungan dengan Skor Maternal-Fetal Attachment pada Ibu Hamil
Authors: Sukriani Wahidah , Suryaningsih Endang Koni
Published: July 2019

Maternal-Fetal Attachment (MFA) is a bond between mother and fetus during pregnancy. MFA plays an important role in maternal and fetal health and affects mothers' decisions in healthy behaviors during pregnancy. Several factors predicted to affect the MFA is the age of pregnancy, maternal age, gravida, pregnancy status, marital status, occupation, income and education of the mother. This study aims to determine the factors associated with maternal-fetal attachment scores in pregnant women in the Panarung Puskesmas Palangka Raya. This was an observational analytic study with a cross-sectional design. A sample in this research is a pregnant woman who does a pregnancy examination at Puskesmas Panarung Kota Palangka Raya. The instrument used in this research is the Indonesian version of prenatal attachment inventory (IPAI). Data analysis was done by logistic regression. The results of statistical tests showed a significant relationship between gestational age with MFA score (p<0.05). Mothers with a gestational age >28 weeks had a better MFA score because the mother already felt the presence of her fetus.
Pengaruh Teknik Relaksasi Nafas Dalam terhadap Penurunan Nyeri pada Pasein Fraktur
Authors: Aini Lela , Reskita Reza
Published: July 2019

Fracture is a crack on bones that is caused by trauma, or other physical energy so that the medical fracture patient will experience start from light until a heavy level of pain. According to data RSI Siti Khadijah Palembang, the number one of patients fractures tend to increase in 2016 as many 423 people. The aim of this study is to see whether there is or is not any breath relaxation technique in case of relieving the pain of fracture patients. This study is using the pre-experimental design in an involving a subject group, with One group Pretest-Posttest project. Sample taking technique is performed with Purposive Sampling method that consumes 30 respondents. This study is performed on 15th of June- 14th of July 2017 in RSI Siti Khadijah Palembang. The summary of the research shows that before the internal breath relaxation technique is done from 30 respondents, 10 of them experience the pain on scale of 4 as equal as (35,7%), either experience theÂ  reduction after the breath relaxation technique is done on scale of 2 and 3 each 8 respondents or as equal as (28,6%). The statistics test result that is using the Wilcoxon check (p-value=0.001) < Î± (0,05) is obtained which that means there is an effect of breath relaxation technique according to the pain revelation of medical fracture patients in RSI Siti Khadijah Palembang on 2017. With this study, it is expected that health workers can implement deep breathing relaxation techniques to reduce pain in fracture patients.
Latihan Slow Deep Breathing dan Aromaterapi Lavender terhadap Intensitas Nyeri pada Klien Post Seksio Sesaria
Authors: Aprina Aprina , Hartika Rovida , Sunarsih Sunarsih
Published: July 2019

The World Health Organization (WHO) sets the standard for the birth of a sexually assault operation in a country to be around 5-15 percent per 1000 births worldwide. Based on Basic Health Research (2013) the level of childbirth sectio caesarea in Indonesia has exceeded the maximum limit of 5-15% WHO standard. The rate of cesarean delivery in Indonesia 15.3% of the 20,591 mothers who gave birth within the last 5 years surveyed from 33 provinces. This cesarean delivery may allow for higher complications than normal delivery. The usual complication is a pain. One of the handling interventions of pain with minimal side effects is nonpharmacological management, such as slow-breathing exercises and lavender aromatherapy. This study aims to determine differences in the intensity of pain in postoperative patients sectio caesarea undertaken slow deep breathing exercise with aromatherapy lavender in RSUD Dr. H. Abdul Moeloek Lampung Province in 2018. This type of research uses a quantitative method using quasi-experimental design with Non-Equivalent Control Group design approach. A technique of sampling using purposive sampling technique as much as 60 respondents, 30 respondents group slow deep breathing and 30 respondents aromatherapy group lavender. The study period began on May 18, 2018, to June 30, 2018, in the Pomegranate Room RSUD Dr. H. Abdul Moeloek Lampung Province. Statistical test using t independent Mann Widney. The results showed that there was a difference of slow deep breathing exercise with lavender aromatherapy on the intensity of pain in patients in post sectio caesarea patients in the Pomegranate Room RSUD Dr. H. Abdul Moeloek Lampung Province Year 2018 (p-value=0.000). Researchers suggest that patients can use lavender aromatherapy to reduce the level of pain postoperative sectio caesarea.
Pemberian Fraksi Daun Kemangi (Ocimum americanum L.) terhadap Spermatozoa Tikus Putih Jantan (Rattus norvegicus)
Authors: Vinnata Nora Novia , Salni Salni , Nita Sri
Published: July 2019

The major cause of a spermatogenetic process disorder in testis is free radical. One of the traditional medicines commonly used as an aphrodisiac is Kemangi plant. Rosary Basil leaf (Ocimum americanum L.), Indonesian name is Kemangi, contains active substances, such as flavonoid, saponin, tannin, and triterpenoid/steroid which is antioxidant and fertility. The purpose of the present research was to analyze the effect of testis weight, diameter, epithelium thickness, morphology, and spermatozoa amount of male white mouse (Rattus norvegicus) after feeding fractions of Kemangi leaf (Ocimum americanum L.) This study was experimental with a posttest-only control group design. The research sample size was 24 furrow male white mice Sprague Dawley, 60-74 days old. They were divided into 4 treatment groups, each being fed the fractions of n-hexane, ethyl acetate, and water-ethanol of Kemangi leaf at a dosage of 100 mg/mouse/day, compared to CMC 1% for the control group for 36 days, and then a dissection was done to take out secreted substances and to examine the histology of testis. The result showed that there were increases of testis weight in the treatment group as compared to that of the control (p=0.018). In addition, there were increases in diameter and thickness of seminiferous tubule epithelium of testis, in the morphology of abnormal sperm (p=0.000), and in spermatozoa amount (p=0.020). Fractions of Kemangi leaf can increase testis weight, diameter, and epithelium thickness, morphology, and spermatozoa amount of furrow male white mice Sprague Dawley, particularly the fraction of ethyl acetate.Â
Pengaruh L14 terhadap Peningkatan Kontraksi pada Kala I Persalinan
Authors: Lathifah Neneng Siti , Iqmy Ledy Octaviani
Published: July 2019

The old partus is one of the causes of maternal death. Based on the date The Renstra of Provincial Health Office (2015) found that the old average partus in the world caused maternal mortality by 8%, in Indonesia by 9% and in Lampung province by 0,63%. The purpose of this study is to determine the effect of L14 against increasing contractionÂ  in the first stages labor mother in BPM Lia Maria Bandar Lampung Regency 2018. This type of research uses quantitative research with quasy experiment. The population in this study were all patients inpartuÂ  in the first stages labor mother at BPM Lia Maria Bandar Lampung 2018. Amounted to 83 people. Samples to 42 people. Technic Sampling Purposive Sampling With sample criteria divided into two, namely inclusion and exclusion. The data collection tool used in this research is to fill in the observation sheet and fill partograph. The statistical test used is T-Test. Statistical test results obtained p-value 0.000<0.05. For practice land or BPM can be used as a solution that massage at the L14 point given to the mother in part at the active phase affects the increase in contraction, so that it can speed up the labor process and without harmful side effects.
Pengaruh Pemberian Air Kelapa (Cocos nucifera. L) pada Media Agar Darah terhadap Pertumbuhan Bakteri Mycobacterium tuberculosis
Authors: Nuraeni Maria , Sebayang Rosnita
Published: July 2019

Tuberculosis is still becoming a health problem in Indonesia. High prevalence of Tuberculosis has encouraged efforts so that patients get treatment immediately. The gold standard to diagnose the disease is by performing bacteriae culture. The culture media for Mycobacterium tuberculosis is quite expensive and also takes quite a long period to let the bacteriae grow up. A blood agar plate is a nonselective media enabling the growth almost all bacteriae. Hopefully, the growth of Mycobacterium tuberculosis becomes more rapid by providing coconut water on a blood agar plate. This study was to provide the effects of provision coconut water with the concentration 50%, 75% and 100% on blood agar plate which were incubated at temperature 35 C and 37 oC. This was an experimental study using pure strainÂ  Mycobacterium tuberculosis (H37RV). The result of the study showed that Mycobacterium tuberculosis was able to grow up in a blood agar plate with coconut water 100% concentration which added to the media. Incubation time was 14 days at temperature 35Â°C and 37Â°C. Regression logistic test showed a significant value of the concentration, temperature, and duration variable were 0,738, 0,872 and 0,720, respectively. There was no effect of coconut water concentration, temperature dan incubation period to the growth of Mycobacterium tuberculosis.
Kadar Debu terhadap Kapasitas Vital Paru pada Masyarakat di Sekitar PT Semen Baturaja
Authors: Trigunarso Sri Indra , Yushananta Prayudhy , Ainin Fernanda Kurnun
Published: July 2019

Function disorders were generally occurred due to individual factors and environmental factors. One of the industries that experienced a lot of development was PT. Semen Batu Raja which is located in Kelurahan Way Lunik. Dust particles with a size of fewer than 50 microns that normally fly can enter the workers' respiratory tract by being sucked in during breathing (ILO, 1998). Public Health Center of Way Lunik mentioned that the prevalence of ARI that occurred during 2016 amounted to 243 cases. The purpose of this study was to determine the relationship of cement dust levels to vital lung capacity in the community around PT. Semen Batu Raja in 2017. The research method was cross-sectional design. Independent variable was humidity of the house, room temperature, ventilation, smoking habits, gender, age, length of stay, and knowledge. While the dependent variable was lung vital capacity. Based on the results of the study, of the 145 Panjang community respondents around PT. Semen Batu Raja obtained 82 respondents who were diagnosed with pulmonary function disorders. Factors that have a significant influence to pulmonary function disorders were ambient dust levels with mean value 171.5 Âµg / Nm3 (0.025), home ventilation with mean value â‰¥ 10% (0.041) and smoking history of respondents with the greatest risk was active smokers. Other factors that were not statistically related were house humidity (0.041) mean 63.2%, house temperature (0.654) mean 29.5â°C, gender, length of stay (0.82), and knowledge (0.654) This study is expected to be reference studies and studies for several parties.
Efektivitas Relaksasi Progresif dalam Mengurangi Gejala Depresi Pasien Diabetes Melitus Tipe 2
Authors: Rumahorbo Hotma , Avianti Nani , Zaini Desmaniarti
Published: July 2019

The prevalence of Diabetes Mellitus (DM) in Indonesia shows an increase from 1.1% in 2007 to 2.1% in 2013, with the most cases being Type 2 Diabetes Mellitus. DM is a chronic disease that cannot be cured but can be controlled by healthy lifestyle and medicine. DM patients who cannot control their blood sugar levels, they will experience acute and chronic complications such as diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy, causing the patient to undergo hospital treatment for the management of blood sugar levels and complaints arising from the accompanying illness. This situation makes the patient stress and depression which will aggravate the disease. This study was to measure the effectiveness of progressive relaxation interventions on depressive symptoms of DMT-2 patients. The study design used Quasi-Experimental two groups pre and post-test design, with 61 samples consisting of 31 intervention groups and 30 control groups. The intervention group was given guidance and progressive relaxation exercises 2 times a day for 3 consecutive days with a duration of 30 minutes each exercise. The results showed that progressive relaxation interventions in DMT-2 patients reduced depression scores by -11,368 units significantly (p=0.001). Variable that makes it difficult to reduce depression symptoms were blood glucose levels. Blood glucose levels were increasing depression scores by 0.012 units. The conclusion was a progressive relaxation intervention effectively reduce depression scores of DMT-2 patients. Controlling the patient's blood glucose levels is important in improving the effectiveness of progressive relaxation interventions to reduce depressive symptoms of DMT-2 patients.
Faktor Resiko Penyakit Infeksi Menular Seksual (IMS)
Authors: Tuntun Maria
Published: July 2019

Sexually transmitted infections (STIs) are venereal diseases that can be transmitted by 30 types of pathogens through sexual intercourse. The purpose of this study is to find out the risk factors for STI disease in dr. H Hospital. Abdul Moeloek Lampung Province in 2012 - 2016. Type of descriptive analytic research with a cross-sectional design. Research place in RSUD dr. H. Abdul Moeloek Lampung Province, in November-December 2017. The population in this study were patients with STIs recorded in the medical record book of 2012-2016 as many as 191 people and a sample of 186 people. The results of the study obtained 4 types of STIs caused by bacteria, namely gonorrhea, syphilis, condyloma, and bartolinitis. The age range of STI patients is 12-62 years, and the most in the 12-25 year age group is 93 people (50%). The most STI sufferers are men, 100 people (53.8%), with the highest education is high school, which is 121 people (65.1%), more STI patients who work are 102 people (54.8%), and STI sufferers who more from Bandar Lampung, 103 people (55.4%). Risk factors associated with the type of STI are gender (p-value=0.012) and work (p-value=0.012), while age (p-value=0.718), education (p-value=0.368), and residence address (p-value=0.088) there is no relationship with the type of STI.