bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPROVEMENT OF THE MODEL OF INFORMATION PROTECTION IN SOCIAL NETWORKS
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Lukova-Chuiko N.V. , Toliupa S.V. ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Pogasiy S.S. ,   Simon Kuznets Kharkiv National University of Economics, Kharkiv, Ukraine, Laptieva T.O. ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Laptiev S.O. ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: November 2024

In Ukraine, the right to privacy is a constitutional guarantee, and the protection of personal data is one of the areas in which such a guarantee should be implemented. The subject of our research will not be objects in general, but dynamic systems of information protection in social networks in the mathematical sense of the term. Descriptions of dynamical systems for various problems depending on the law of evolution are various: by means of differential equations, discrete mappings, the theory of graphs, thetheory of Markov chains, etc. The choice of one of the methods of description determines the specific form of the mathematical model of the corresponding dynamic system. Theoretical study of the dynamic behavior of a real object requires the creation of its mathematical model. Most of the known approaches to modeling differ in what parameters they use as input information in modeling and what characteristics of the simulated system are calculated and output to the model. The article presents the development of an improved mathematical model of information protection in a social network depending on its specific parameters. Such as trust, reputation, the impact of data security threats from the dissemination of information between users, the impact of data security threats from user interactions, the impact of data security threats from user interaction, and the impact of data security threats from the length of the path between users. However, it should be noted that the parameters of the social network are much more. But we consider these parameters to be the most influential. Therefore, we pay attention to these specific parameters.Mathematical modeling of the improved model of information protection in the social network depending on its specific parameters is carried out. Graphic results reflect the current picture of protection of social network information from external influences. The obtained results confirm the adequacy of the developed mathematical model of information protection in the social network.
Premenstrual syndrome as a risk factor for postpartum depression
Authors: Sidorov A. Е. , Denisova T. G. , Zhuravleva N. V.
Published: November 2024

Aim: to identify a possible association between postpartum depression (PPD) and symptoms of premenstrual syndrome (PMS).

Materials and Methods. A total of 296 women who completed pregnancy to delivery initially agreed to participate in the cohort study, 260 completed the entire survey. All the women, who agreed to take part in the study, were offered three questionnaires. The first questionnaire was collected on day 7–10 postpartum, the second – in 6 weeks and the third – in 6 months after delivery. These questionnaires contained questions of the Edinburgh Postpartum Depression Scale (EPDS) and special questions identifying pre-pregnancy signs of PMS, as well as some lifestyle and medical history questions.

Results. Of 296 participants, 7.1 % had retrospectively identified symptoms of PMS, with 2.7 % showing severe symptoms of premenstrual dysphoric disorder (PMDD). In the total cohort, there was a direct correlation between previous PMS and PPD occurring on day 7–10, 6 weeks and 6 months postpartum. After parity separation, this association remained statistically significant only in the multipara cohort.

Conclusion. The relationship between the presence of PMS and the development of PPD has been established. Parity can be considered a catalyst for this relationship. The discovered relationship is particularly important for predicting the occurrence of PPD, as well as for a deeper understanding of the pathogenesis, timely diagnosis, prevention, and choice of treatment methods for this complication of the postpartum period.
Effect of synthetic and reduced folic acid on methionine metabolism parameters in various experimental models with Wistar rats
Authors: Sazonova A. P. , Milyutina Yu. P. , Bespalova O. N. , Pachuliia O. V. , Zalozniaia I. V. , Korenevsky A. V.
Published: November 2024

Introduction. Currently, folic acid preparations are administered during preconception period in an empirical manner. Along with synthetic folic acid, there also exists its reduced counterpart 5-methyltetrahydrofolate (5-MTHF). Manufacturers of the latter claim that 5-MTHF overcomes metabolic defects due to c.665C>T gene polymorphism in the methylenetetrahydrofolate reductase (MTHFR), and therefore it is superior to synthetic folic acid (pteroylmonoglutamic acid, PGA). However, no large-scale studies to confirm this hypothesis have been conducted yet.

Aim: to assess an effect of various folic acid preparations on methionine metabolism in experimental models with Wistar rats.

Materials and Methods. A chronic hyperhomocysteinemia (HHC) was induced in sexually mature female Wistar rats by daily methionine supplementation. After HHC development, experimental animals were administered PGA or 5-MTHF. Some animals without HHC also received folic acid supplements or water. Blood samples were collected at 3 time points (1, 2 weeks and 1.5 months after folate preparation administration) to quantitate level of homocysteine (HC), plasma folic acid and red blood cell count.

Results. It was verified that HHC developed in mature Wistar rats after methionine supplementation, with HC level being significantly higher (p < 0.05) than in control group. Use of folic acid supplements during HHC caused by methionine load did not result in lower HC level. In experimental animals administered PGA or 5-MTHF, blood serum folic acid level and red blood cell count did not change upon longer drug administration. No advantage for 5-MTHF vs. synthetic folic acid on HC levels and erythrocyte folate accumulation was observed. Instead of the expected decline in HC level in HHC models related to the examined folate preparations, the opposite effect was obtained. In case of pre-existing non-folate-dependent chronic HHC, HC level increased from time point 1 to time point 3.

Conclusion. Chronic non-folate-dependent HHC, induced by chronic oral methionine was self-limiting in experimental models; additional folate supplementation resulted in sharply increased plasma HC level. Experimental models with Wistar rats showed that no further accumulation of folic acid occurs upon its optimal levels in plasma and red blood cells. The study revealed no advantages for 5-MTHF over synthetic folic acid in lowering blood plasma HC level and folic acid accumulation in erythrocytes.
Caesarean section through the prism of fine art and mythological stories
Authors: Matveeva N. V. , Makatsariya N. A.
Published: November 2024

Caesarean section is one of the ancient and most outstanding operations, with roots going deep into the past. It shows unmatched significance in that it is the only operation responsible for the lives of two people – mother and child. Hypotheses about the origin of the term a Сaesarean section, the history of its development and methods underlying execution the operation are discussed here. The article highlights issues aimed at Сaesarean section in fine art, the historical stages of this operation and their reflection in fine arts. Studying artistic works related to Caesarean section helps us to better understand its impact on mankind and social consciousness.
Notes pa una propuesta categorial d’obres escéniques pa la determinación teatrolóxica d’un corpus del Teatru Popular Asturianu
Authors: Buelga Casas Sergio
Published: November 2024

El presente trabayu preséntase pa establecer una propuesta primera de llinies d’analís que describan un sistema de carauterístiques fundamentales de les obres dramatúrxiques y escéniques del Teatru Popular Asturianu, énte la inesistencia d’un estudiu teatrolóxicu fonderu que presente unos parámetros d’identificación sobre los que sofitar el so corpus d’obres escéniques.
Estes categoríes estudien, dende una visión teatrolóxica, dellos aspeutos dramáticos, estéticos, ambientales y sociollingüísticos singulares del suxetu d’estudiu y que presenten, de forma xeneral, los espectáculos del Teatru Popular Asturianu.
Cada ítem analizáu presenta la so fundamentación histórica dientro’l movimientu, amás de les funciones que cumplen dientro de les obres.
Conocemento y actitudes hacia el eonaviego
Authors: Castro Huerta Eva
Published: November 2024

Neste documento realízase un estudio sociollingüístico del eonaviego, úa de las llinguas propias del occidente del Principao d’Asturias, y úa aproximación a la súa realidá entre el alumnao d’ESO y Bachillerato del IES Galileo Galilei de Navia. Este centro acoye alumnos de las poblacióis de Navia, Cuaña y, en menor medida, Villayón, El Franco, Tapia, Bual y Castropol.
En primeiro llugar resúmese y coméntase la situación actual de la llingua según el III Estudio Sociollingüístico del Navia-Eo., pásase a estudiar de primeira mao, mediante un cuestionario nel que se recoye el trabayo de campo realizao nel propio centro, la situación actual de la llingua eonaviega entre xente d’edades comprendidas entre los 12 y los 18 anos de los conceyos xa mencionaos.
Possibilities of gene, cellular and pharmacological approaches to correct age-related changes
Authors: Kitaeva Kristina V. , Solovyeva Valeriya V. , Filin Ivan Yu. , Mukhamedshina Yana O. , Rizvanov Albert A.
Published: November 2024

Improvement of the human habitat has led to an increase in average life expectancy. Long life goes hand in hand with old age, which reduces the quality of human life and it is an acute social problem. Thus, the search for approaches that can improve the quality of life, the ability to live it without age-related diseases is an extremely urgent task. Aging of the body begins with the aging of cells, in which the activation of the aging process occurs through the induction of specific signaling pathways, which irreversibly divides the life of any cell into “before and after”. Aging cells are able to influence their microenvironment, secreting more inflammatory signaling molecules and inducing pathological changes in neighboring cells. The accumulation and long-term preservation of aged cells lead to deterioration of the condition of tissues and organs, and ultimately to a decrease in the quality of life and an increased risk of death. Among the most promising approaches to the correction of aging and age-related diseases are pharmacological, gene and cell therapy. Increasing the expression of aging suppressor genes, using certain populations of native and genetically modified cells, as well as senolytic drugs can help delay aging and associated diseases for a more distant future. This review examines currently studied approaches and achievements in the field of anti-aging therapy, in particular gene therapy using adeno-associated vectors and approaches based on cell therapy.
Modelling project activities for future teachers within the innovative infrastructure of pedagogical universities: integrative solutions
Authors: Demidova N. N. , Golovina I. V. , Medvedeva T. Yu. , Paputkova G. A. , Votintsev A. V.
Published: November 2024

Introduction.In the quest to enhance the training of future teachers, particular emphasis is placed on identifying the educational potential of new learning environments within pedagogical universities under the Ministry of Education of Russia. These institutions have undergone infrastructure updates as part of federal programs designed to support education.Aim.Theaimof this study is to develop an original model for organising the project activities of student teachers, taking into account the contemporary infrastructural capabilities of pedagogical universities under the Ministry of Education of Russia.Methodology, methods and techniques.The methodological foundation of this research is grounded in the principles of community development pedagogy and the design of evolving educational systems. The integration of integrative, synergetic, environmental, and system-activity approaches facilitated the identification and development of components within the author’s model for organising project activities for future teachers in the context of pedagogical technoparks, such as “Quantorium”, and technoparks focused on universal pedagogical competencies in higher education institutions under the Ministry of Education of the Russian Federation. The validation of the developed model was conducted through expert assessments.Results.The authors developed the model for organising project activities for future teachers within the innovative infrastructure of pedagogical universities. The main components of the model are outlined, including integrative objectives and anticipated outcomes of students’ project activities, interdisciplinary project content, and a technological component that facilitates the transformation of interdisciplinary project content into personally meaningful experiences through the technology of collaborative distributed project activities. The study identifies and justifies the conditions necessary for the effective implementation of the developed model, focusing on the management of processes, resources, and participants involved in interdisciplinary project activities.Scientific novelty.Integrative processes, within the context of this study, are regarded as a pedagogical phenomenon that reflects the interconnections among the objects, processes, and subjects involved in project activities.Practical significance.The research materials can be utilised in the development of programmes aimed at enhancing the infrastructure of pedagogical universities. They can also assist in the refinement of educational curricula for training teaching staff, particularly in disciplines that prepare future educators to effectively organise project-based activities within contemporary educational environments.
Comparative study of endotracheal tube cuff inflation with air versus alkalinized lidocaine on hemodynamic response during extubation
Authors: Nadkarni Avani S , Shah Pooja Arpan , Chavda Dushyant B , Patel Jatin B , Thomas Sara Mary
Published: November 2024

The increased use of cuffed endotracheal tube during general anaesthesia has been associated with increased incidences of hemodynamic stress leading to tachycardia and hypertension during emergence from general anaesthesia. Hence it is planned to conduct a study inflating the endotracheal tube cuff with air as compared to inflation with 2% alkalinized lidocaine during intubation to observe the changes in hemodynamic stress response during extubation.

This study aimed to compare the effects of endotracheal tube cuff inflation with air versus 2% alkalinized lidocaine on hemodynamic stability during extubation (primary outcome) and to assess associated side effects (secondary outcome).

This Randomised prospective observational study was done on 40 patients between the age group of 18 to 65 years of both gender belonging to American Society of Anaesthesiologists (ASA) physical status 1 and 2 undergoing elective surgeries requiring general anaesthesia. They were separated into Group A – cuff inflated with air and Group L – cuff inflated with alkalinized lidocaine prepared by taking 9cc of 2% lidocaine and adding 1cc of sodium bicarbonate and using approximately 4-5 cc to inflate the cuff. Hemodynamic changes at baseline, induction, intraoperatively, during extubation and post-extubation were recorded.

Haemodynamic responses were monitored at extubation & 2,4,6,8,10,15 minutes after extubation showed better hemodynamic stability in Group L than Group A.

The study suggested that endotracheal tube cuff inflated with alkalinized lidocaine have shown better hemodynamic stress response during extubation and post-extubation.
To evaluate and correlate the effectiveness of epidural depth equation versus pre-procedural US guided epidural block: A randomized controlled trial
Authors: Rana Shelly , Garg Mohini , Verma Versha , Sharma Nanish , Rani Aayushi
Published: November 2024

Ultrasound assisted pre-procedural epidural depth estimation has improved the safety and efficacy of epidural block. Currently, the incorporation of pre-procedural ultrasound guided epidural derived equation(EDE) has significantly improved the accuracy of epidural depth estimation especially in the parturients. However, the accuracy of EDE derived epidural depth alone has not been compared to the actual epidural needle depth in non-obstetric patients.

This study compared the efficacy of epidural depth equation (EDE) versus pre-procedural US-guided epidural block in patients scheduled for orthopedic surgeries under the combined spinal epidural block (CSE). The primary outcome was the number of attempts for successful epidural insertion, the secondary outcomes were correlations of EDE-calculated epidural depth with actual needle depth and pre-procedural US-guided epidural depth.

One hundred patients, 20-60 years, ASA physical status I and II, body mass index (BMI) 18.5–29.9 kg.m were randomized into two groups. In group US (n=50), the pre-procedural US-guided skin to epidural depth was measured and the point of insertion of the epidural needle was marked. Whereas, in group E (n=50), the skin epidural depth was measured using the epidural depth equation (EDE). The epidural block was instituted by the loss of resistance technique in both groups. The primary outcome was the number of attempts for successful epidural insertion, the secondary outcomes were correlations of EDE-calculated epidural depth with actual needle depth and pre-procedural US-guided epidural depth.

The needle passes were 1.10±0.08, and 1.18±0.05 in groups US, E respectively (P=0.251). A significantly strong correlation was observed between epidural depth by US and EDE (r2=0.915, P=0.001). Whereas, a weak correlation was observed in the EDE-measured epidural depth and actual needle depth (r=0.402, P =0.04).

Although comparable needle attempts were observed in both groups, the weak correlation of epidural depth by EDE with actual needle depth doesn’t support its use alone. The strong correlation of epidural depths by EDE and US encourages EDE assisted with pre-procedural US-guided epidural block.
A comparison of analgesic efficacy between oral pregabalin, gabapentin, and melatonin as non-opioid anaesthesia for robotic-assisted laparoscopic surgeries: A prospective randomized double-blinded clinical study
Authors: Nagendran Nagapriya , Daisy Monica , Nagarajan Girimurugan
Published: November 2024

Opioid-sparing anesthesia is increasingly used in surgery, though effectiveness varies. Given the anxiety-pain correlation, anxiolytics like gabapentinoids and melatonin may offer benefits. This study compares the preemptive use of pregabalin, gabapentin, and melatonin for postoperative analgesia in robotic-assisted laparoscopic surgeries (RALS).

The aim of this study is to investigate postoperative analgesia in patients undergoing robotic-assisted laparoscopic surgeries under non-opioid anesthesia. The objectives are to evaluate perioperative hemodynamics, assess the perioperative sedation score during the surgical procedures, determine the requirement for rescue analgesia in the postoperative period, and measure the perioperative anxiety score in patients undergoing these surgeries.

Sixty patients, aged 18-60 with ASA PS grade 1 & 2 and BMI < 35 kg/m², undergoing elective robotic-assisted laparoscopic surgeries (RALS) were randomly assigned to receive pregabalin (Group P), gabapentin (Group G), or melatonin (Group M). After standard pre-anesthetic assessments and premedication, patients received pregabalin 150 mg, gabapentin 900 mg, or melatonin 6 mg one hour before surgery. Hemodynamics and anxiety, VAS, and sedation scores were monitored postoperatively at 1, 2, 6, and 12 hours. Primary outcome was postoperative analgesia assessed by VAS, with rescue analgesia administered for VAS > 4.

Baseline characteristics were balanced among groups. Gabapentin significantly reduced VAS scores (1.25 ± 0.44) and extended time to rescue analgesia (9.48 ± 0.69 hours). Anxiety scores and Ramsay sedation scores (1.45 ± 0.51) were comparable, but Group G showed lower sedation. Hemodynamics remained stable.

Gabapentin improved postoperative pain outcomes in RALS, supporting its use for individualized pain management in these surgeries. Differences in pain intensity, time to rescue analgesia, and sedation levels highlight the need for personalized approaches. Further research in various surgical contexts is recommended to optimize perioperative care.
Effectiveness of dextrose prolotherapy for chronic musculoskeletal pain: A prospective observational study
Authors: Digraje Sunita Ashok , Chavan Dhanashri Ganesh , Virkar Nilam Dharma , Rustagi Preeti Sachin , Deshmukh Prakash Rajendra
Published: November 2024

The increasing prevalence and burden of musculoskeletal conditions has led to an interest in effective nonsurgical solutions, which are more cost efficient and minimally invasive. Prolotherapy is an alternative therapeutic procedure used for management of chronic musculoskeletal conditions which involves injection of irritant solution into affected area. Primary objective of this study was to assess effectiveness of prolotherapy in relieving pain.

This study was undertaken to assess the effectiveness of prolotherapy with Inj. Ropivacaine 0.25% & Dextrose 12.5% in patients with chronic musculoskeletal pain. The primary objective was to evaluate reduction in pain 3 months after procedure. Secondary objectives were to assess number of sessions of prolotherapy required, patient satisfaction and complications if any.

Seventy patients of either sex aged 18 years and above, diagnosed with a chronic musculoskeletal pain condition, who were selected for the prolotherapy as the treatment modality, were included in the study. All patients received prolotherapy with 0.25% ropivacaine and 12.5% in the involved area.

A Wilcoxon signed-rank test showed that there was statistically significant difference in mean VAS, 3 months after prolotherapy as compared to mean VAS pre-procedure. The mean VAS reduced from 6.61 ± 0.95 at the beginning of the study, reduced to 0.88 ± 1.95 by the end of the study (p = 0.000.)

Maximum volume of drug required for adequate pain relief by prolotherapy was 30 cc with the mean of 17.53 ± 7.28. 58.3% of the study population needed 2 sessions of prolotherapy while 10% required 3 sessions. 80% of patients, had more than 50% pain relief at the end of 3rd month after prolotherapy.

Prolotherapy using 12.5% Dextrose + 0.25% Ropivacaine offers minimally invasive, cost effective and safe management option for patient with chronic musculoskeletal pain.
Evaluation of local anaesthetic with adjuvants for postoperative analgesia through ultrasound-guided Fascia Iliaca compartment block in hip procedures
Authors: Thangaraju Thamizhmathi , Kumar Prem , Daisy T Monica
Published: November 2024

Hip surgeries often result in significant postoperative pain, affecting early mobilization and rehabilitation. The Fascia Iliaca compartment block (FICB), guided by ultrasound, is a regional anaesthesia technique that can reduce this pain. The addition of adjuvants to local anaesthetics may enhance the block's duration and quality. This study evaluates the efficacy and safety of adding dexamethasone and dexmedetomidine as adjuvants to 0.25% ropivacaine for postoperative analgesia in hip procedures.

The study aims to compare the duration and quality of postoperative analgesia of ropivacaine and ropivacaine with additives such as dexmedetomidine and dexamethasone for ultrasound-guided fascia iliaca compartment block in patients undergoing three different lower limb orthopaedic procedures.

To assess and compare the duration of post-operative analgesia between 0.25% ropivacaine, ropivacaine with dexmedetomidine and ropivacaine with dexamethasone.

: To assess and compare the time of requirement of rescue analgesia between the three groups

This prospective, randomised, double-blind, placebo-controlled trial involved 60 patients undergoing hip surgeries including Total hip replacement (THR), Dynamic Hip Screw (DHS), and Proximal Femoral Nailing (PFN) divided equally into three groups. Group A received 0.25% ropivacaine with dexamethasone, Group B received 0.25% ropivacaine with dexmedetomidine, and Group C received 0.25% ropivacaine with a placebo. The primary outcomes measured were the duration of analgesia and postoperative pain scores. Secondary outcomes included the need for rescue analgesia and the incidence of side effects.

Patients who received dexmedetomidine or dexamethasone experienced significantly longer durations of analgesia and lower postoperative pain scores in the first 24 hours compared to those who received the placebo. Additionally, the need for rescue analgesia was reduced, and the incidence of side effects was comparable between the groups receiving adjuvants and the placebo group.

The order of better analgesia and prolonged duration was best with ropivacaine and dexmedetomidine, next best with ropivacaine and dexamethasone when compared to ropivacaine without adjuvant.
Dexmedetomidine - lidocaine nebulisation for awake nasotracheal intubation: An observational cross-sectional study
Authors: Chauhan Amit Kumar , Yadav Neeru , Ramakrishnan Priya , Saini Sunil
Published: November 2024

Optimal airway topicalisation is the key to successful and smooth awake intubation in anticipated difficult airway. Dexmedetomidine nebulisation has been used effectively as premedication and could be a useful adjunct to lidocaine for awake fiberoptic intubation (AFOI). This study evaluated the efficacy of dexmedetomidine-lidocaine nebulisation for AFOI.

To compare the efficacy of Dexmedetomidine with lignocaine versus Plain Lignocaine nebulization to achieve successful airway placement for awake fiberoptic intubation (AFOI). To assess the degree of patient comfort during the procedure on basis of cough score, gaging reflex score, intubating conditions, vocal cord position, patient behaviour and to assess the hemodynamic stability and the time taken for AFOI.

96 adult patients, ASA grades I-III with anticipated difficult intubation requiring AFOI for elective surgery were enrolled. Patients received nebulisation with dexmedetomidine 1mcg/kg + 4ml of 4% lidocaine (Group A, n=48) & 4ml of 4% plain lidocaine (Group B, n=48). Outcomes were assessed by an independent observer. Primary outcome of cough and gag reflex was assessed on basis of four-point intubation condition assessment score. Secondary outcomes assessed were patient comfort using five-point intubation comfort scale, three-point behaviour scale, hemodynamic stability, additional sedation, lidocaine aliquots, intubation attempts and complications. Fischer exact test was used for categorical variables and Mann -Whitney / independent student t-test for continuous variables.P values < 0.05 was considered statistically significant.

: Both groups displayed similar demographic profiles. While all patients were successfully intubated, Group A exhibited better intubating condition grades (p<0.001) and lower cough scores compared to Group B (p<0.001). Patient comfort (p<0.001) and hemodynamic stability (p<0.05) was better in Group A. Only 3 patients in Group A required additional sedation compared with 19 patients in Group B (p<0.001).

This study demonstrated superior efficacy of dexmedetomidine- lidocaine nebulisation in providing optimal intubating conditions for AFOI.
Awake hybrid intubation technique for managing anticipated difficult airway in a patient undergoing decompressive cervical laminectomy: A case report
Authors: Thangaraju Thamizhmathi , Gunasekaran Kaliyaperumal
Published: November 2024

Patients undergoing decompressive cervical laminectomy pose significant challenges for airway management due to anatomical considerations and potential difficulties in intubation. Traditional approaches may not suffice in ensuring safe and effective airway management in such cases. Here we present a case report on the successful management of an anticipated difficult airway with restricted neck movement in a 56-year-old male patient with C3-C6 extradural space-occupying lesion with C4 C5 extra foraminal extension undergoing decompressive laminectomy Awake Hybrid Intubation technique for Managing Anticipated Difficult Airway in a patient undergoing decompressive Cervical Laminectomy. A 3D-printed indigenously made video laryngoscope was used to view the glottis and a Flexible video bronchoscope loaded with an armoured reinforced tube was introduced orally which served as a guide for successful endotracheal tube placement in the first attempt without any adverse events. As an incidental finding, a mass of about 1x2cm was found just beneath the glottis with the aid of a bronchoscope, intubation was successfully done without traumatising the mass.
High flow nasal oxygenation and videolaryngoscopy - the two saviours in a case of Prader-Willi syndrome: A case report
Authors: Gaba Prachi , Singh Aparna , Sharma Kush , Gupta Lalit
Published: November 2024

Prader-Willi syndrome (PWS) is a rare genetic disorder characterized by hypothalamic-pituitary abnormalities, hypotonia, hyperphagia, and a high risk of morbid obesity, which complicates both general and regional anesthesia. Patients with PWS face additional challenges, including disturbances in thermoregulation, arrhythmias, cor pulmonale, and convulsions. These factors make anesthetic management particularly challenging, necessitating careful planning and monitoring.

We report the anesthetic management of a 7-month-old infant with genetically confirmed PWS who underwent bilateral orchidopexy under general anesthesia. The patient’s preoperative evaluation revealed significant hypotonia and a predisposition to respiratory complications. During the procedure, advanced airway management techniques, including the use of C-MAC and high-flow nasal oxygenation (HFNO), were employed to alleviate the risk of difficult airway and respiratory failure. The anesthesia team meticulously monitored the patient's vital signs and thermoregulation throughout the surgery to prevent arrhythmias and other complications associated with PWS.

The successful anesthetic management of a child with Prader-Willi syndrome requires a multidisciplinary approach, thorough preoperative planning, meticulous intraoperative monitoring, and vigilant postoperative management to minimize the risk of complications in this vulnerable patient population.
Technology of estimating nitrogen dioxide and carbon dioxide emissions by large industrial centers of Western Siberia
Authors:   Altai State University, Lagutin A.A. , Volkov N.V. ,   Altai State University, Mordvin E.Y. ,   Altai State University, Sinitsin V.V. ,   Altai State University
Published: November 2024

The paper presents results of the development and testing with real data of a technology for assessing the emission of nitrogen dioxide and carbon dioxide from sources in Western Siberia. The NO2 content in the region’s troposphere was determined using data from the TROPOMI spectroradiometer of the Sentinel-5 Precursor satellite. The method of computational experiments to obtain quantitative estimates of CO2 emissions from large industrial facilities in the region consists in a joint analysis of data from TROPOMI/Sentinel-5P for the NO2 content and data from the OCO-2 orbiting carbon observatory for the CO2 content. The main procedure for data analysis is the approximation of gas content distributions along the trajectory of the OCO-2 satellite by the vector function of the Gaussian distribution. Approximation parameters (full width at half maximum and amplitude), as well as data about direction and speed of wind (obtained from the ERA5 reanalysis) are used to quantify CO2 emissions. The technology developed by the authors for obtaining quantitative estimates of anthropogenic CO2 emissions for the industrial centers of Western Siberia without using OCO-2 data is based on an empirically established relationship between approximation parameters of gases distributions. The results of the work are quantitative estimates of the content of nitrogen dioxide in the atmosphere and lower troposphere of Western Siberia; the annual cycle and interannual variability of NO2 in the troposphere, obtained using data from the TROPOMI/Sentinel-5P spectroradiometer; a technology for obtaining quantitative estimates of CO2 emissions from large industrial centers of the region.
Vacciner contre la COVID-19 ? Interroger l’agenda hégémonique de la santé globale depuis la Guinée
Authors: Sylla Gassim , Le Marcis Frédéric
Published: November 2024

La Guinée présente une faible couverture vaccinale contre la COVID- 19 (28% en 22 février 2023). Au lieu de penser ce faible taux de vaccination comme un échec, nous proposons de le discuter comme une mise en cause locale de l’agenda de la santé globale. Cette étude repose sur l’ethnographie de la mise en œuvre de la vaccination en Guinée, réalisée par les deux auteurs, de mars 2020 à octobre 2022 dans la capitale et à l’intérieur du pays. Des acteurs de la santé et des individus vaccinés ou non ont été interrogés, et le contexte politique dans lequel la campagne s’est déroulée a été analysée. Loin d’une lecture homogène des acteurs de la santé globale, nous décrivons en quoi la politique vaccinale est tributaire de relations multilatérales et bilatérales qui façonnent son offre vaccinale. L’approvisionnement en intrants, la situation sanitaire, les tensions politiques concomitantes à la COVID-19 mettent en cause la légitimité des mesures préventives, notamment la vaccination. D’autre-part, les actions promues dans l’arène de la santé globale pour répondre à l’épidémie de COVID-19 (confinement, vaccination) ont fait fi des conditions politiques et biologiques que le virus rencontre en Guinée. En mobilisant la notion de biologie située (Lock), il s’agit de discuter de la pertinence d’un agenda universel pour la santé globale.
DESDE EL PRINCIPIO ES UNA MADRE: EL PAPEL DE LAS MUJERES ZENÚ EN LAS LUCHAS POR LA TIERRA
Authors: Hernández Zharic
Published: November 2024

: Esta investigación aborda el papel de las mujeres Zenú del resguardo San Andrés de Sotavento en la lucha por la tierra. Se analiza cómo las percepciones sociales sobre la defensa de la tierra han mutado desde la tenencia del territorio ancestral a la lucha contra el extractivismo y las consecuencias de la crisis climática, entendiendo estas violencias como parte del capitalismo y la colonización moderna, que se encuentran interrelacionadas. Por ello, mediante la construcción de relatos con un enfoque interseccional, se evidencian experiencias individuales y proyectos grupales que construyen imaginarios del territorio y sus conflictos. Asimismo, se presenta una aproximación al valor de la economía del cuidado y las estrategias comunitarias de resistencia, buscando resaltar los aportes invisibilizados de las mujeres en esta larga lucha. Palabras Claves: genero; economía del cuidado; crisis climática; conflictos territoriales; resguardo indígena.
Luka: un Juego Digital que utiliza la Argumentación para Promover el Discurso no Polarizado en Alumnos Brasileños de Primaria
Authors: Leitão Selma , Silva Alisson Michel , Teofilo Nathalia Patricia
Published: November 2024

Transformar a los alumnos en pensadores críticos, pedagógicamente comprometidos, es uno de los pilares de la Base Curricular Común Nacional (Brasil, 2019). El juego Luka persigue este objetivo a través de tres mecánicas, inspiradas en estrategias anti-prejuicios: Recolección de Tabletas de Tiempo, Tablero de Argumentos y Debates. El objetivo fue identificar si el juego Luka favorecía el discurso no polarizado entre los participantes, a través de un debate no estructurado en WhatsApp con ocho alumnos y un profesor de una clase de octavo grado de una escuela privada de Recife (Brasil). Se realizó un análisis micro y macroestructural del debate. Se observó que los contenidos del juego fueron utilizados y adaptados constantemente por los alumnos a lo largo del debate. Hubo un bajo compromiso de los alumnos con sus puntos de vista, lo que indica una baja polarización discursiva. Dos alumnos hicieron comentarios directos sobre la contundencia de los argumentos de sus compañeros. El profesor, a lo largo del debate, desarrolló acciones discursivas (pragmáticas y argumentativas) que iniciaron y mantuvieron el proceso argumentativo.
Dysmenorrhea Decoded: Unveiling The Mysteries of Painful Periods
Authors: V Bhuvaneshwari
Published: November 2024

Dysmenorrhea, commonly known as painful menstrual periods or menstrual cramps, is a condition that affects many individuals with a uterus. Dysmenorrhea is a prevalent and often underestimated gynecological condition that affects a significant portion of the female population during their reproductive years.
A Review on Probability of Breast Cancer of Womens in Different Regions of the World
Authors: Ullah Muhammad kaleem
Published: November 2024

It is concluded that breast cancer is 2nd most diagnosed disease in female in the United States. Both sexes can get disease and females are more likely to this disease. Females with age 50 to 74 were much likely to develop breast cancer. In America and England, the five-year survival rates range from 80 to 90 percent.
Risk Analysis of Sulfur Dioxide (SO2) Exposure to Public Health Around Kolaka District Nickel Processing Plant
Authors: Azis Sheril , R. Azizah  , Jalaludin Juliana
Published: November 2024

Introduction: Sulfur dioxide is an air pollutant that is mostly sourced from burning fossil fuels. Data from the Pomalaa Health Center in 2019 indicates a high incidence of Acurate Respiratory Infection (ARI), with 1,943 reported cases. This study aims to assess the respiratory health risk for communities near the nickel processing plant in Pomalaa District. Methods: This research employs an observational cross-sectional design alongside Environmental Health Risk Analysis (EHRA), the study sampled 122 out of 13,207 respondents using simple random sampling. The analysis was carried out with the kolmogorov-smirnov test and EHRA. Results and Discussion: EHRA results show an inhalation rate of 0.63 m3/hour, with an exposure time of 24 hours/day, an exposure frequency of 365 days/year, and exposure durations of 25 years for real-time projections and 30 years for lifetime projections. SO2 levels have surpassed national quality standards, with the highest concentration recorded at Point 4, measuring 0.576 mg/m3. Dose-response analysis, based on US-EPA data, indicates a level of 0.21 mg/m3. The average intake value for real-time exposure is 0.081 mg/kg/day, and the average intake value for 30-year lifetime is also 0.081 mg/kg/day. Kolmogorov-smirnov test results show a p-value of 0.200 for body weight, while p-values for exposure duration, exposure time, exposure frequency, SO2 concentration, intake rate, age group, intake value, and RQ are all 0.000. Conclusion: Most respondents in this study had health risks that were within safe limits. Nickel processing plant companies and local governments should conduct regular monitoring and control emissions from mining activities, including SO2
Association Between Indoor Air Quality and Sick Building Syndrome Among Workers in Food Outlets in Selangor, Malaysia
Authors: Ismahani Isman Nur Izzah , Jalaludin Juliana , Suhaimi Nur Faseeha , Fahimah Hashim  , Abdul Rohim Tualeka
Published: November 2024

Introduction: Indoor air pollution, causing health issues like Sick Building Syndrome (SBS), is the third largest global contributor to disability-adjusted life years, emphasizing the urgent need for improved indoor air quality. This study aimed to determine the association between Indoor Air Quality (IAQ) and SBS among workers at food outlets in Selangor, Malaysia. Methods: A cross-sectional study was carried out among 107 workers in mall, new and old food outlet. A set of standardized and validated version questionnaires of the Industry Code of Practice on Indoor Air Quality (ICOP IAQ) 2010 was distributed to obtain respondents’ sociodemographic information, symptoms present at the workplace, and psychosocial information. Results and Discussion: The study found significant differences in temperature (p = 0.004), air velocity (p = 0.037), ultrafine particles (p = 0.005), and carbon dioxide (CO2) concentrations (p = 0.006) in malls, new and old food outlets. Workers in old food outlets had the highest prevalence of SBS (66.7%), compared to those in new outlets (60.5%) and mall outlets (64.7%). Environmental characteristics, such as increased dust and particulate matter during renovation (OR = 6.17, 95% CI = 1.34-28.34), repair (OR = 2.43, 95% CI = 1.03-5.76), along with temperature variations (OR = 7.21, 95% CI = 2.52-20.66) significantly influencing SBS. Conclusion: SBS prevalence in food outlets is not significantly linked to IAQ parameters, but exposure to UFP and PM2.5 may contribute to its development. However, it is significantly associated with workplace renovations and repairs for interior design, as well as varying temperatures.
Management Challenges of Marine Ornamental Fish and Their Utilization as The Sustainable Potential Marine Resources
Authors: Andriyono Sapto , Kartika Gde Raka Angg , Syarif Ahmad Fahrul , Alam Md. Jobaidul
Published: November 2024

Coral ornamental fish become potential fishery commodities, providing opportunities and challenges in managing fishery resources in Indonesia. This activity has long been done and has become one cause of damage to coral reefs in Indonesia. Changes in paradigm and technology currently applied in Indonesia are expected to provide a gradual regulatory and coral reef ecosystem improvement. The commercial trade of ornamental fish requires attention and rigorous regulation. The marine ornamental fish trade activity is expected to improve and drive the coastal communities' economy. The significant increase in exploitation is expected to be controlled with the right regulations. This regulation must refer to the concept of sustainable development established through the Sustainable Development Goals (SDGs), especially SDGs number 14 concerning life underwater. The existence of reef fish is enough to provide economic movement, which continues to heat up, especially after the pandemic and the reopening of flights and export activities abroad. However, multi-stakeholders should ratify the concept of sustainability and environment-friendliness. Support from the government, academia, industry, and community groups must be aligned and in tune to achieve sustainable development goals. Providing accurate information related to the biological characteristics of reef fish is an essential contribution for researchers that can be used directly by the community. Thus, the exploitation of reef fish can align with efforts to conserve coral reef ecosystems closely related to global warming and climate change.
KOMBINASI NANOPARTIKEL KITOSAN DAN TURUNAN SELULOSA DALAM PEMBUATAN EDIBLE COATING TERHADAP AKTIVITAS BAKTERI DAN ORGANOLEPTIK PEMPEK IKAN TENGGIRI
Authors: Shabrina Fadiah , Mahasri Gunanti , Mubarak A. Shofy
Published: November 2024

Pempek adalah makanan tradisional Indonesia yang memiliki masa simpan sekitar 16 jam pada suhu ruang. Untuk mengawetkan pempek, pedagang tradisional sering menggunakan tapioka, tetapi ada juga yang menambahkan zat berbahaya seperti formalin dan boraks untuk memperpanjang masa simpannya. Pengawet sintetis dapat menyebabkan masalah kesehatan, sehingga mendorong permintaan akan metode pengawetan alami seperti pelapis yang dapat dimakan. Penelitian ini bertujuan untuk mengembangkan dan mengevaluasi edible coating berbasis selulosa dan nanopartikel kitosan atau chitosan nanoparticles(CSNPs) untuk memperpanjang umur simpan pempek dari ikan Tenggiri. Edible coating adalah lapisan tipis yang dapat dimakan yang melindungi makanan dan mengatur kelembapan, oksigen, dan transfer lemak. Penambahan CSNPs dapat meningkatkan sifat fungsional dan stabilitas pelapis berbasis selulosa.
Penelitian ini merupakan penelitian eksperimental yang dibagi menjadi dua tahap. Tahap pertama meliputi karakterisasi edible coating menggunakan Rancangan Acak Lengkap (RAL), dengan pengujian meliputi aktivitas antimikroba, daya serap air, dan viskositas, yang dilakukan dengan 5 perlakuan dan 4 kali pengulangan. Tahap kedua adalah mengaplikasikan coating pada pempek dan mengevaluasi masa simpannya, dengan fokus pada kualitas TPC dan organoleptik menggunakan Rancangan Acak Lengkap (RAL) dua faktor dengan 3x6 perlakuan dan 3 kali pengulangan.
Hasil penelitian menunjukkan adanya pengaruh yang signifikan (P<0,05) dari berbagai formulasi terhadap karakteristik edible coating. Formulasi kombinasi CMC dan CSNP (P5) dipilih sebagai coating pempek. Pada tahap kedua, perlakuan pempek yang dilapisi dengan coating CMC dan CSNP (C2) efektif mempertahankan kualitas pempek hingga hari ke-3 pada suhu ruang dan hari ke-12 pada suhu kulkas.
In Vitro Evaluation of Brown Algae Extract from Sargassum aquifolium in Inhibiting Aeromonas hydrophila, the Causative Agent of Motile Aeromonas Septicemia (MAS)
Authors: Ernawati Waruwu  , Anak Agung Ayu Putri Permatasari  , Wiradana Putu Angga , I Made Wisnu Adhi Putra  , Putu Eka Sudaryatma  , Muhammad Khaliim Jati Kusala
Published: November 2024

The widespread use of antibiotics in aquaculture has been associated with the development of multidrug resistance in the environment and in humans. This is also exacerbated by the application of high stocking densities in fish farming systems, including catfish (Clarias sp). This study aims to see the potential of Sargassum aquifolium extract, which is a brown macroalgae, as an antibacterial agent for fish disease, Aeromonas hydrophila. Previous studies have revealed the phytochemical profile of S. aquifolium extract, but its effectiveness as an antibacterial agent has not been studied. The ethanol extract concentrations used were 20%, 40%, 60%, 80%, and 100% with two repetitions. The MIC test method was carried out to determine the lowest concentration of S. aquifolium ethanol extract that could inhibit the growth of Aeromonas hydrophila bacteria, while the MBC test was carried out to determine the bactericidal properties against A. hydrophila bacteria. SEM analysis was carried out to determine the morphological damage to A. hydrophila bacterial cells that had been treated with S. aquifolium ethanol extract. Based on the results, it was revealed that S. aquifolium extract could inhibit the growth of A. hydrophila highest with a very strong category at a concentration of 100%. The MIC value of S. auifolium extract was shown at a concentration of 100% but did not cause bacterial cell death based on the MBC value and SEM observations. These findings indicate that S. aquifolium extract has the potential to inhibit the growth of A. hydrophila. Increasing in vivo parameters such as the immune system, production performance, and survival in catfish is still needed to strengthen these results.