bluuebunny/crossref_metadata_2025 huggingface dataset:
Chromatin Regulators as Prognostic Biomarkers In Patients With Pheochromocytomas And Paragangliomas
Authors: Kong Linlin , Tang Shaofang , Wang Jiao , Ma Tianshuai , Wang Xinyuan , Wu Keyang , Ding Li , Liu Ming , He Qing
Published: June 2023

Chromatin regulators participated in tumorigenesis of various cancers while less research about its relationships with pheochromocytomas and paragangliomas. The aim of our study was to discover potential chromatin regulators as biomarkers for pathogenesis as well as prognosis of pheochromocytomas and paragangliomas. In this study, we explored expression patterns of pheochromocytomas and paragangliomas from the Gene Expression Omnibus database and 870 manually curated verified chromatin regulators. Then 185 differentially expressed chromatin regulators were verified which biological function were explored using Gene Ontology，Disease Ontology，Moreover, Kyoto Encyclopedia of Genes and Genomes pathways enrichment analysis. Besides protein-protein interaction network indicated 10 Hub genes. Their diagnostic performance as well as related drugs were valued by Receiver Operating Characteristics analysis, The Drug Signature Databases separately. Then we use TISIDB database to verify the relationship between 10 Hub genes and immune infiltration of pheochromocytomas and paragangliomas. Finally, 2 key genes were screened after Kaplan-Meier survival analysis and miRNA regulatory network was constructed based on Key genes by TargetScan microRNA 2017 in the Enrichr platform and TargetScanHuman (version8.0) platform. In conclusion, we identified 10 chromatin regulatorsespecially EZH2 and TAF7 which had high diagnostic performance and their functions were complicated in tumorigenesis of pheochromocytomas and paragangliomas. Likewise, the immune infiltration of pheochromocytomas and paragangliomas was intrinsically complex and these Hub genes mainly had negative correlation with immune infiltrating cells as well as immune infiltrating functions. Consequently, these chromatin regulators verified in our research could help to a further evaluation in pathogenesis and prognosis of pheochromocytomas and paragangliomas.
Trial registration
None
AI and data driven media analysis of TV content for optimised digital content marketing
Authors: Nixon Lyndon , Apostolidis Konstantinos , Apostolidis Evlampios , Galanopoulos Damianos , Mezaris Vasileios , Philipp Basil , Bocyte Rasa
Published: June 2023

In order to optimise digital content marketing for broadcasters, the Horizon 2020 funded ReTV project developed an end-to-end process termed "Trans Vector Publishing'' and made it accessible through a Web based tool termed "Content Wizard''. This paper presents this tool with a focus on each of the innovations in data and AI-driven media analysis to address each key step in the digital content marketing workflow: topic selection, content search and video summarization. Firstly, we use predictive analytics over online data to identify topics the target audience will give most attention to at a future time. Secondly, we use neural networks and embeddings to find the video asset closest in content to the identified topic. Thirdly, we use a GAN to create an optimally summarized form of that video for publication, e.g. on social networks. The result is a new and innovative digital content marketing workflow which meets the needs of media organisations in this age of interactive online media where content is transient, malleable and ubiquitous.
Non-secretory Multiple Myeloma Associated with Diffuse Osteosclerotic Bone Lesions: A Case Report and Review of Cases since 1997
Authors: Veeramachaneni Tanooha , DeBevits John , Anderson Larry D. , Jaso Jesse M. , Kaur Gurbakhash
Published: June 2023

Background: Multiple myeloma is the second most common hematologic malignancy typically involving monoclonal immunoglobulin secretion by malignant plasma cells and lytic bone lesions. Sclerotic lesions appear in 3% of cases, and only 1-3% of multiple myeloma patients produce no detectable paraprotein. This case involves a challenging diagnosis of a rare presentation of both non-secretory and osteosclerotic multiple myeloma.
Case Presentation: A 59-year-old woman with prior history of breast cancer presented with 2 months of back pain and was found to have T1 and T11 sclerotic lesions on imaging. Positron emission tomography (PET) revealed additional L4 sclerotic lesions and right manubrium as well as a single lytic lesion of the right ilium. Biopsy revealed 40% plasma cell infiltrate producing monoclonal lambda light chains. Protein electrophoresis was normal. The patient was absent of POEMS Syndrome features. The patient was diagnosed with osteosclerotic multiple myeloma (OMM) and initiated on chemotherapy and received an autologous stem cell transplant. Repeat PET demonstrated stabilization of sclerotic lesions and decreased metabolic activity of the lytic lesion. She is currently on maintenance Revlimid.
Conclusions: OMM is an extremely rare subtype of classical multiple myeloma (CMM), with less than 50 cases reported prior to 1997. This paper presents the most comprehensive current review of OMM since. OMM presents in younger patients with no sex preference most commonly with back pain, dyspnea, and weakness/fatigue. 29% of patients reviewed were South Asian, warranting further research into risk factors for this population. Hypercalcemia is rare in OMM, while renal insufficiency and anemia are more common than in CMM. OMM has median infiltrate of 45% with even distribution of kappa and lambda chain monoclonal gammopathy. It most commonly involves the vertebrae but has greater involvement in the pelvis and long bones than CMM. OMM is more indolent with better survival. Our case represented a challenging diagnosis with normal typical laboratory markers of MM and unremarkable findings on SPEP given that the OMM also was non-secretory. Although rare, OMM should be considered in diagnosis of patients with persistent back pain despite 1-2 months of conventional conservative treatment using computed tomography or magnetic resonance imaging.
Investigating to detect the fake medicines using blockchain technology
Authors: Upadhyay Anurag , Bhargava Anshuman , Kumar J Sathish
Published: June 2023

In recent years, the use of counterfeit drugs has become a significant public health concern globally. To tackle this problem, various technologies have been employed, including blockchain, due to its inherent characteristics such as transparency, immutability, and decentralization. In this paper,a method is proposed for detecting fake medicines using blockchain technology. The system tracks the entire lifecycle of a drug, from manufacturing todistribution, and maintains a decentralized ledger that records each transaction. This approach enables stakeholders to verify the authenticity of drugs inreal-time, ensuring that only genuine medicines reach patients. The system’seffectiveness in detecting counterfeit drugs is evaluated using a simulated environment, and the results show that the proposed method can effectively detectfake medicines with high accuracy and reliability. Overall, the use of blockchaintechnology in the detection of counterfeit drugs provides a promising solutionto the issue of fake medicines in the healthcare industry.
Materials sustainability of thermoelectric generators for waste heat utilization
Authors: Bohra Anil Kumar , Vitta Satish
Published: June 2023

Amount of waste heat exergy generated globally ~ 69.058 EJ can be divided into, low temperature < 373 K, 30.496 EJ, medium temperature 373 K – 573 K, 14.431 EJ and high temperature > 573 K, 24.131 EJ. The minimum number of thermoelectric pn-junctions required to convert this high temperature exergy into electrical power using currently known best materials is found to increase from 8.22x1011 to 24.66x1011 when the aspect ratio of the legs increases from 0.5 cm− 1 to 1.5 cm− 1. To convert the low temperature exergy, 81.76x1011 to 245.25x1011 junctions will be required. The amount of alloys required to synthesize these is of the order of ‘millions of tons’ which means the elements, Bi, Te, Pb, Sb, Sn and Se required is also of similar magnitude. The current production of these elements however falls far short of this requirement by several orders of magnitude, indicating significant materials supply chain risk. The production of these elements and devices, even if resources are available, will emit millions of tons of CO2 showing that current alloys are non-sustainable. It therefore becomes clear that alternate materials with low energy and emissions footprint as well as minimal supply chain risk need to be pursued.
Static and dynamical signatures of Dzyaloshinskii-Moriya interactions in the Heisenberg model on the kagome lattice
Authors: Ferrari Francesco , Niu Sen , Hasik Juraj , Iqbal Yasir , Poilblanc Didier , Becca Federico
Published: June 2023

Motivated by recent experiments on Cs_22Cu_33SnF_{12}12
and YCu_{3}3(OH)_{6}6Cl_{3}3,
we consider the {S=1/2}S=1/2
Heisenberg model on the kagome lattice with nearest-neighbor
super-exchange JJ
and (out-of-plane) Dzyaloshinskii-Moriya interaction
J_DJD,
which favors (in-plane) {Q=(0,0)}Q=(0,0)
magnetic order. By using both variational Monte Carlo and tensor-network
approaches, we show that the ground state develops a finite
magnetization for J_D/J \gtrsim 0.03 \mathrm{-} 0.04JD/J≳0.03−0.04;
instead, for smaller values of the Dzyaloshinskii-Moriya interaction,
the ground state has no magnetic order and, according to the fermionic
wave function, develops a gap in the spinon spectrum, which vanishes for
J_D \to 0JD→0.
The small value of J_D/JJD/J
for the onset of magnetic order is particularly relevant for the
interpretation of low-temperature behaviors of kagome antiferromagnets,
including ZnCu_{3}3(OH)_{6}6Cl_{2}2.
For this reason, we assess the spin dynamical structure factor and the
corresponding low-energy spectrum, by using the variational Monte Carlo
technique. The existence of a continuum of excitations above the magnon
modes is observed within the magnetically ordered phase, with a broad
peak above the lowest-energy magnons, similarly to what has been
detected by inelastic neutron scattering on
Cs_{2}2Cu_{3}3SnF_{12}12.
Feasibility and acceptability of a novel intervention to improve hand hygiene behavior in rural Liberian health facilities
Authors: Tantum Lucy K. , Gilstad John R. , Horng Lily M. , Tandanpolie Amos F. , Styczynski Ashley R. , Letizia Andrew G. , Luby Stephen P. , Arthur Ronan F.
Published: June 2023

Hand hygiene is central to the prevention of healthcare-associated infection. In low-income settings, barriers to health worker hand hygiene may include inconsistent availability of hand hygiene supplies at the point of care. However, there is a lack of knowledge of interventions to improve and sustain health worker hand hygiene in these settings. This pilot study evaluates acceptability and feasibility of a personally-worn hand hygiene holster device for improving point-of-care access to alcohol-based handrub (ABHR). Holsters were distributed to clinical staff at a hospital in Liberia in July–September 2021. Data collection included 2,066 structured observations of hand hygiene behavior, six spot checks of supply availability, and focus group discussions with 13 clinical staff. The Integrated Behavioral Model for Water, Sanitation, and Hygiene (IBM-WASH) provided a framework for study design and qualitative analysis. Acceptability of the intervention was high, with users reporting that holsters were comfortable, easy to use, and aligned with their professional identities. Feasibility depended on consistent ABHR availability, which may diminish sustainability of this intervention. The hand hygiene holster is a promising tool for improving health worker hand hygiene behavior, but solutions to ABHR supply chain and distribution constraints are necessary to support sustainability of this intervention.
Neuroprotective Effect of Dexmedetomidine Pretreatment on Sevoflurane-
Initiated Neurotoxicity Via the Mir-204-5p/SOX4 Axis
Authors: Wang Run , Liu Pengfei , Li Fan , Qiao Hui
Published: June 2023

Background:

Sevoflurane (Sev) is a type of volatile anesthetic commonly used in clinic
practices and can initiate long-term neurotoxicity, while dexmedetomidine (Dex) possesses a
neuroprotective function in multiple neurological disorders.

Objective:

This work expounded on the function of Dex pretreatment in Sev-initiated neurotoxicity.

Methods:

At first, human neuroblastoma cells (SK-N-SH cells) were treated with different
concentrations of Sev or Dex, followed by the cell counting kit (CCK)-8 assay to decide the
appropriate concentrations of Sev or Dex. Cell viability, lactate dehydrogenase (LDH) productions,
and apoptotic rate of SK-N-SH cells were examined by the CCK-8 assay, LDH cytotoxicity kit, and
flow cytometry assay in sequence. Further, reactive oxygen species (ROS) levels and proinflammatory
cytokine contents were examined by the ROS assay kit and the enzyme-linked
immunosorbent assay kits. The expression patterns of microRNA (miR)-204-5p and SRY-box
transcription factor 4 (SOX4) in SK-N-SH cells were measured by real-time quantitative polymerase
chain reaction or Western blotting. The binding relationship between miR-204-5p and SOX4 was
confirmed by the dual-luciferase assay. After transfection of miR-204-5p mimics or SOX4 siRNA,
the role of the miR-204-5p/SOX4 axis in Sev-initiated neurotoxicity was detected.

Results:

Sev treatment reduced SK-N-SH cell viability in a concentration-dependent manner, and Dex
pretreatment diminished Sev-initiated neurotoxicity. Mechanically, Dex pretreatment limited Sevinduced
upregulation of miR-204-5p and further increased SOX4 expression levels. miR-204-5p
upregulation or SOX4 knockdown averted the neuroprotection function of Dex pretreatment in Sevinitiated
neurotoxicity.

Conclusion:

Dex pretreatment decreased miR-204-5p expression levels and upregulated SOX4
expression levels, palliating Sev-initiated neurotoxicity.
Effective Reduction of Tau Amyloid Aggregates in the Presence of Cyclophilin
from Platanus orientalis Pollens; An Alternative Mechanism of
Action of the Allergen
Authors: Mehrabi Masomeh , Bijari Nooshin , Akbari Vali , Ranjbar Samira , Karima Saeed , Sankian Mojtaba , Ojaghi Sara , Khodarahmi Reza
Published: June 2023

Background:

A hallmark pathology of Alzheimer's disease (AD) is the construction of neurofibrillary
tangles, which are made of hyperphosphorylated Tau. The cis-proline isomer of the
pThr/Ser-Pro sequence has been suggested to act as an aggregation precursor according to the
‘Cistauosis’ hypothesis; however, this aggregation scheme is not yet completely approved. Various
peptidyl-prolyl isomerases (PPIases) may specifically isomerize cis/trans-proline bonds and restitute
Tau's ability to attach microtubules and may control Tau amyloid aggregation in AD.

Methods:

In this study, we provided experimental evidence for indicating the effects of the plant Cyclophilin
(P-Cyp) from Platanus orientalis pollens on the Tau aggregation by various spectroscopic
techniques.

Results:

Our findings disclosed that the rate/extent of amyloid formation in the Tau sample which is
incubated with P-Cyp decreased and these observations do not seem to be due to the macromolecular
crowding effect. Also, as proven that 80% of the prolines in the unfolded protein are in the trans conformation,
urea-induced unfolding analyses confirmed this conclusion and showed that the aggregation
rate/extent of urea-treated Tau samples decreased compared with those of the native protein. Also,
XRD analysis indicated the reduction of scattering intensities and beta structures of amyloid fibrils in
the presence of P-Cyp. Therefore, the ability of P-Cyp to suppress Tau aggregation probably depends
on cis to trans isomerization of proline peptide bonds (X-Pro) and decreasing cis isomers in vitro.

Conclusion:

The findings of the current study may inspire possible protective/detrimental effects of
various types of cyclophilins on AD onset/progression through direct regulation of intracellular Tau
molecules and provides evidence that a protein from a plant source is able to enter the cell cytoplasm
and may affect the behavior of cytoplasmic proteins.
Progress in Research on CNPY2 in Diseases
Authors: Chen Ke-qian , Zhang Yu-qing , Wang Zong-bao , Wang Shu-zhi
Published: June 2023

Canopy FGF signaling regulator 2 (CNPY2) is a novel angiogenic growth factor. In recent
years, increasing evidence highlights that CNPY2 has important functions in health and disease.
Many new blood vessels need to be formed to meet the nutrient supply in the process of tumor
growth. CNPY2 can participate in the development of tumors by promoting angiogenesis. CNPY2
also enhances neurite outgrowth in neurologic diseases and promotes cell proliferation and tissue
repair, thereby improving cardiac function in cardiovascular diseases. Regrettably, there are few
studies on CNPY2 in various diseases. At the same time, its biological function and molecular
mechanism in the process and development of disease are still unclear. This paper reviews the recent
studies on CNPY2 in cervical cancer, renal cell carcinoma, prostate cancer, colorectal cancer,
lung cancer, gastric cancer, hepatocellular carcinoma, cerebral ischemia-reperfusion injury, spinal
cord ischemia-reperfusion injury, Parkinson’s disease, ischemic heart disease, myocardial ischemiareperfusion
injury, myocardial infarction, heart failure, and non-alcoholic fatty liver disease. The
biological function and molecular mechanism of CNPY2 in these diseases have been summarized in
this paper. Many drugs that play protective roles in tumors, cardiovascular diseases, non-alcoholic
fatty liver disease, and neurologic diseases by targeting CNPY2, have also been summarized in this
paper. In addition, the paper also details the biological functions and roles of canopy FGF signaling
regulator 1 (CNPY1), canopy FGF signaling regulator 3 (CNPY3), canopy FGF signaling regulator
4 (CNPY4), and canopy FGF signaling regulator 5 (CNPY5). The mechanism and function of
CNPY2 should be continued to study in order to accelerate disease prevention in the future.
Synthesis of Phentermine and its Derivatives
Authors: Upadhyaya Khushbu , Shukla Shruti , Meena Bharti Parkash , Dwivedi Jaya
Published: June 2023

In recent years, a growing global concern has been obesity. Patients with obesity are at
major risk for developing a number of diseases. These diseases may significantly impact patient’s
daily lives and increase the mortality rate. Over a year, medication for obesity has undergone substantial
changes. An amphetamine-like prescription drug called Phentermine (Adipex-P, Lomaira)
is used to suppress appetite. In the last few years, Phentermine and its derivatives have attracted
much attention due to their use in weight reduction; by reducing appetite or prolonging the feeling
of fullness, it can aid in weight reduction. So, reviewing the synthesis of Phentermine and its derivatives
becomes imperative. Therefore, various synthetic routes for Phentermine (from benzaldehyde,
isopropyl phenyl ketone, dimethyl benzyl carbinol) and its derivatives synthesis, involving
ortho-palladation, are also reviewed here comprehensively.
Analysis of the Safety and Effectiveness of Lenvatinib + TACE-HAIC + PD-1 Inhibitor for Intermediate and Advanced Hepatocellular Carcinoma
Authors: Yang Yuguang , Tang Hui , Mai Cong , Zhang Xin , Kuang Jiawen , Tang Yunqiang
Published: June 2023

Background:

Hepatocellular carcinoma (HCC) is the sixth most prevalent cancer and the
fourth leading cause of cancer death in the world.

Aims:

This study aimed to investigate the efficacy and safety of Lenvatinib + PD-1 inhibitor + TACEHAIC
(LePTaHAIC) versus Sorafenib + TACE (SorTACE) for patients with intermediate and advanced
HCC.

Methods:

In this retrospective study, patients diagnosed with BCLC stage B/C HCC were included. All
patients were treated with LePTaHAIC (LePTaHAIC group) or SorTACE (SorTACE group) between
September 2019 and September 2020. Outcomes, including progression-free survival (PFS), conversion
surgical resection rate, objective remission rate (ORR), overall survival (OS), and treatment-related adverse
events (AEs) were analyzed and compared between the two treatment modalities.

Results:

In total, 65 eligible patients were recruited, with 35 assigned to receive LePTaHAIC and 30 assigned
to undergo SorTACE. Median PFS (11.4 vs. 5.13 months) and OS (26 vs. 10.08 months) in the
LePTaHAIC group were significantly higher compared to the SorTACE group (both P < 0.0001). The
ORR (mRECIST standard) of the LePTaHAIC group was markedly higher compared to the SorTACE
group (71.4% vs. 40%, P = 0.01). In the LePTaHAIC group, 11 patients underwent surgical resection
(BCLC stage B: n = 4, BCLC stage C: n = 7) and 3 patients achieved complete pathological remission
(pCR), while one patient in the SorTACE group underwent surgical resection. The conversion surgical
resection rate of the LePTaHAIC group was significantly higher compared to the SorTACE group [31.4%
(11/35) vs. 3.3% (1/30), P = 0.004]. Patients with LePTaHAIC had more frequent grade 3-4 treatmentrelated
AEs, especially thrombocytopenia, compared to the SorTACE group (22.9% vs. 3.3%, P = 0.02).

Conclusion:

LePTaHAIC exhibited acceptable toxic effects and improved survival compared to
SorTACE in intermediate and advanced HCC.
Design, Synthesis, in silico and in vitro Evaluation of New Combretastatin
A-4 Analogs as Antimitotic Antitumor Agents
Authors: Hussein Shaker A. Abdul , Kubba Ammar , Balakit Asim A. , Tahtamouni Lubna H. , Abbas Ali H.
Published: June 2023

Background:

Combretastatin A-4 (CA-4) binds β-tubulin at the colchicine-binding site
preventing tubulin from polymerizing into microtubules. CA-4 and cis combretastatin analogs
isomerize to the trans form resulting in decreased cytotoxicity and anti-tubulin activity. However, the
excellent anti-cancer potential and relatively simple molecular structure of CA-4 provide an encouraging
starting point for the development of new, more stable and more potent anti-tubulin compounds.

Objective:

This study aimed to synthesize a new series of compounds derived from 4-(3,4,5-
trimethoxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione derivatives (compounds 10-12) with substituted
phenyl group at C5 of the triazole ring (B-ring) as analogs of CA-4, with different alkyl and
aryl side chain substituents at the triazole moiety, resulting in the permanent cis configuration of the
two phenyl rings. Moreover, the anti-cancer activities of the new compounds were assessed.

Methods:

Chemical synthesis was carried out by conventional organic methods. The newly synthesized
CA-4 analogs were characterized by FT-IR, 1HNMR, 13CNMR, and HR-MS(ESI) techniques.
Molecular docking studies, including docking score (ΔG), ADMET, DFT, and molecular similarities,
were performed. The anti-proliferative activity of the new compounds against three human cancer
cell lines (A549, Hep G2, and HCT-116) and the normal cell line WI-38 was evaluated using the
MTT assay, and their ability to inhibit tubulin polymerization, and consequently, their effects on cell
cycle progression and induction of apoptosis were assessed.

Results:

Molecular docking studies showed that compounds 11b and 11d exhibited the highest docking
scores (-13.30 and -14.01 Kcal/mol, respectively) into the colchicine-binding site, scores very
close to the reference drug colchicine (-13.50 Kcal/mol), and that hydrogen bonding and hydrophobic
interaction are essential for binding. The most active cytotoxic compound, 11b, had potent IC50
values against the three human cancer cell lines (3.83, 10.20, and 10.67 μM against Hep G2, HCT-
116, and A549, respectively) while exhibiting low cytotoxicity against non-cancer-human WI-38,
suggesting that compound 11b targets rapidly growing cancer cells. Moreover, compound 11b exhibited
potent anti-tubulin activity which was comparable to CA-4. Targeting microtubules caused cell
cycle arrest at the G2/M phase resulting in the induction of apoptosis.

Conclusion:

These findings indicate that compound 11b is a promising β-tubulin-binding compound
with antimitotic action that has the potential to treat cancer.
Inhibitory Effect of Ascorbic Acid on Glutathione S-transferase from
Human Erythrocytes
Authors: Emre Erat Yunus , Rümeysa Erat Ayşe , Erat Mustafa
Published: June 2023

Background:

Inhibition of certain specific glutathione S-transferase isozymes is associated
with the efficacy of chemotherapy in the treatment of cancer patients.

Objective:

We aimed to determine whether ascorbic acid, which can be used as a drug and antioxidant
food supplement, is a glutathione S-transferase isozyme inhibitor.

Methods:

For this purpose, glutathione S-transferase was first purified from human erythrocytes and the
in vitro effect of ascorbic acid on enzyme activity was investigated. Then, kinetic studies were performed
to evaluate the inhibition potential of ascorbic acid, which was determined to be an inhibitor of
the enzyme.

Results:

The enzyme was purified 1286-fold with a yield of 81% and specific activity of 18.00 U/mg
protein. The effects of ascorbic acid were tested on the in vitro enzyme activity of glutathione Stransferase
and detected to be an inhibitor for the enzyme with 10 mM of IC50 value. Ki constants and
inhibition type were also determined for the enzyme.

Conclusion:

This finding indicates that ascorbic acid can be an effective inhibitor of some GST isozymes
increased in cancer cells. Abundant ascorbic acid intake may prevent cancer formation by
strengthening the antioxidant defense system, on the other hand, it may increase the effectiveness of
cancer treatment by inhibiting the chemotherapy-resistant GST enzyme.
WITHDRAWN: Th17 Overexpression in Severe COVID-19: A Prospective Observational Study
Authors: Gupta Ankesh , Kumar Arvind , Deepak Rakesh Kumar , Arora Umang , Agrawal Aayush , Soneja Manish , Garg Prerna , Kumar Sanchit , Kumar Praveen , Kanga Uma , V Ganesh Kumar , Soni Kapil Dev , Wig Naveet
Published: June 2023

Since the authors are not responding to the editor’s requests to fulfil the editorial requirement, therefore, the article has been withdrawn from the journal "Infectious Disorders - Drug Targets"

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

BENTHAM SCIENCE DISCLAIMER:

It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultane-ously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submit-ting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.
Motivational Interviewing as an Intervention to Improve Antiretroviral
Treatment Initiation Among People who Inject Drugs (PWID): A Pilot
Study in Jakarta and Bandung, Indonesia
Authors: Sukmaningrum Evi , Ayu Astri Parawita , Wongso Lydia Verina , Handayani Miasari , Hendrianti Sarahsita , Kawi Nurhayati Hamim , Kusmayanti Nur Aini , Sulaiman Nurjannah , Irwanto  , Law Matthew , Wisaksana Rudi
Published: June 2023

Introduction:

Progress towards the 95-95-95 target among People Who Inject Drugs
(PWID) with Human Immunodeficiency Virus (HIV) infection was considerably low. A behavioral
approach, such as motivational interviewing (MI), has been recognized as an effective strategy
for improving HIV treatment outcomes among PWID.

Objective:

This study aimed at assessing the impact of MI counselling to improve ARV initiation
among HIV-positive PWID.

Methods:

A cohort design pilot study was performed, and participants were recruited using a convenience
sampling technique. Participants were PWID with HIV who accessed healthcare facilities
in two Indonesian cities. Selected participants were assigned to an intervention group and a
control group. The intervention group followed MI counselling, while the control group received
ART following the standard of care. The participants were assigned to each group based on their
preferences. The data was collected between January 2018 and January 2019.

Results:

In total, 115 PWID with HIV participated in this study in the intervention (n = 30) and
control (n = 85) groups. All but one intervention group's participants started ART, while 68/85 in
the control group did so. Receiving MI counselling significantly contributed to ART initiation. In
addition, the participants were followed-up until 12 months after ARV initiation. During this period,
we found that similar proportions of participants in both groups discontinued the treatment,
and only a small number achieved HIV viral suppression.

Conclusion:

The positive effect of MI counselling on ART initiation provides insight into the
possibility of its wider implementation. Further studies are needed to gain a deeper understanding
of MI counselling and its effect on other outcomes of the HIV treatment cascade.
RATIONAL DRUG USE STATUS OF STUDENTS AT A UNIVERSITY HOSPITAL
Authors: YASLI Gökben , TURHAN Ebru
Published: June 2023

Objective: Irrational drug use is a significant global and public health issue, including in Turkey Turk. This study aims to assess the knowledge and attitudes of students toward rational drug use . Methods: The study population comprised of 1909 students enrolled in Bakırçay University's 2019-2020 academic year. The sample size of the study was 780 students selected through stratified random sampling from each faculty. Data were collected using the "Rational Drug Use Form," which included demographic characteristics, background, drug use attitudes and behaviors, and the Rational Drug Use Scale. The data were analyzed using SPSS 23.0, and a p-value of <0.05 was considered statistically significant. Results: Of the students, 74.4% were female, and 42.3% were male, with a mean age of 19.9. Of the students, 28.2% self-medicated before consulting a doctor when sick, and 57.6% used medication for headaches without consulting a doctor. Additionally, 73.6% of them primarily used over-the-counter painkillers. Based on the Rational Drug Use Scale score of ≥35, which is considered the cut-off point in the literature, 491 students (73.3%) knew about rational drug use Conclusion: The students' knowledge of rational drug use was found to be above the average. However, campus courses and projects must be organized, and medical units should be supported, despite students' awareness of rational drug use
TÜRKİYE’DE TORRANCE YARATICI DÜŞÜNME TESTLERİ ŞEKİLSEL FORMU İLE YAPILAN ARAŞTIRMALARDA 05-14 YAŞ ARASI ÇOCUKLARIN YARATICI DÜŞÜNME GELİŞİMİNİN İNCELENMESİ
Authors: Ülger Kani
Published: June 2023

Alanyazında öğrencilerin yaratıcı düşünme gelişiminin yaşla birlikte arttığı, 05 ve 13 yaş civarında ise keskin düşüş beklendiği belirtilmiş, yapılan çalışma sonuçlarının ilgili yaşlar açısından farklılıklar içermesi nedeniyle, araştırma yapılması önerilmiştir. Bu araştırmanın amacı, 05-14 yaş öğrencilerin yaratıcı düşünme gelişimlerinin incelenmesidir. Bu amaçla, Türkiye’de ilgili yaş aralığında yaratıcı düşünme gelişimleri, TYDT-Şekilsel testle yapılan ölçümler ortak zemininde, 2001 ve 2021 yıllarında yapılan araştırmalar incelenmiştir. Bu çalışma, araştırma sorusu doğrultusunda alanyazın taraması ile rapor edilen sonuçların değerlendirilmesiyle gerçekleştirilmiş ve elde edilen veriler içerik analiziyle incelenmiştir. Toplam 12 araştırmada 1227 öğrencinin ölçüm sonuçları değerlendirilmiştir. Ulaşılan bulgulara göre, öğrencilerin yaratıcı düşünme alt boyutlarında inişli-çıkışlı bir gelişim çizgisi gözlemlenirken, toplam yaratıcılık puanları açısından, 05 yaştan 13 yaşa doğru gelişimin artış içinde olduğu, 13 yaşta durağanlıktan sonra 14 yaşta artışın devam ettiği, dolayısıyla gelişimin yaş ile birlikte arttığı belirlenmiştir. Buna göre, somut düşünme evresinde yer alan 5 yaş ile soyut düşünme evresi 13 yaş civarında yaratıcı düşünme gelişiminde görülen durağanlık, aynı zamanda, okula başlama 5 yaş ile yaklaşık 13 yaşında erken ergenlik evresine geçişin yaratıcı düşünme gelişimine olumsuz etkilerinin olabileceği söylenebilir. Dolayısıyla, öğrencilerin sürekli bir gelişim gösterebilmesi için eğitim alanında önlemler alınmasının gerekli olduğu söylenebilir.
Przebieg procesu inwestycyjnego w budownictwie
Authors: Krupa Barbara
Published: June 2023

Wielość uregulowań, brak spójności przepisów, ilość pozwoleń i opinii różnych organów, które inwestor musi uzyskać skutkują tym, że proces inwestycyjny w budownictwie jest długotrwały i obarczony ryzykiem niepowodzenia. Celem artykułu jest przybliżenie obowiązujących w Polsce przepisów prawa dotyczących procesu inwestycyjnego w budownictwie. Słowa kluczowe: proces inwestycyjny w budownictwie, inwestor, roboty budowlane, kierownik budowy, pozwolenie na budowę, samowola budowlana
Implementation of Preventive and Corrective measures in SCADA based Wind Turbines
Authors: Amin Salman , Soomro Dr Amir Mahmood , Kumar Dr. Mahesh
Published: June 2023

Wind energy is becoming increasingly important in addressing energy demand and environmental sustainability. It is driven by the outstanding offshore wind resource and the need to minimize carbon emissions from energy generation. A growing interest in wind turbine condition monitoring, which allows condition based rather than reactive or scheduled maintenance, stems from the difficulty of accessing and maintaining wind turbines offshore. Vibration analysis and oil debris detection are currently used wind turbine condition monitoring methods. The extra expenditures might be enormous when considering the number of turbines normally put in offshore wind farms, and specialist interpretation is usually required. However, extending SCADA data-based analysis could bring significant value to condition monitoring at little or no expense to the wind farm operator. This Research Paper focuses on wind turbine condition monitoring using only SCADA data. An early detection of operational defects or breakdowns allows for regular maintenance or repair, decreasing downtime and potentially preventing further damage. Comparing incoming operational SCADA data with results for relevant variables, like component temperature, produced from applicable models trained on SCADA data from a healthy wind turbine, yields useful component condition indicators. Anomalies in the variables of interest in the SCADA data indicate impending breakdowns. This method is used to derive machine-to-machine comparison of component condition Compared to developing separate turbine models, this saves significant computing work and model complexity. A real-time wind turbine power curve is also created using SCADA data and compared to a reference power curve to quickly discover abnormal behavior based on slight variations in the power curve.
Correlates on Job Performance, Job Satisfaction, and Demographics of State University Employees
Authors: S. Bulilan Ramil
Published: June 2023

This survey looked into the significant relationship between employees’ job performance and satisfaction levels, and the demographic profile of the employees of Bohol Island State University in Bohol, Philippines. Towards this end, using the descriptive-survey method of research with a quantitative-correlational approach, and the universal sampling technique, it surveyed 345 permanent employees. Specifically, the study identified the respondents’ age, sex, educational attainment, and length of service in the institution; the relationship between their demographics and their level of job performance, and the extent of job satisfaction. Findings revealed that the respondents were in their young adulthood stage, dominated by females, experienced employees in the institution, and had high educational credentials. Moreover, they performed well in their duties and were somewhat satisfied with their jobs. Despite the insignificant results of almost all of the null hypotheses tested, the respondents considered their length of service as a contributory factor that would influence their level of job performance and extent of job satisfaction, which implies that the longer their work experience, the better their work performance would be expected from them, and the more satisfied they are with their jobs. It indicates, therefore, that high levels of job satisfaction did not necessarily lead to employee performance. There may be other must-be studied factors that influenced one’s job performance and satisfaction.
Pegcetacoplan in the treatment of geographic atrophy
Authors: Kumar Madhukar , Singh Rishi P
Published: June 2023

Geographic atrophy (GA) secondary to age-related macular degeneration is a leading cause of visual deterioration in the global elderly population, often causing a decreased quality of life. Perifoveal atrophy can significantly affect reading, low-light vision and driving. Similarly, foveal atrophy can cause defects in central visual acuity. While the complement cascade has been implicated as playing a pivotal role in disease pathogenesis, no approved treatment for GA currently exists. Two concurrent phase III trials, DERBY and OAKS, assessed pegcetacoplan (Apellis Pharmaceuticals, MA, USA), a selective complement component C3 inhibitor, with regard to reduction in GA progression. This article reviews the available clinical trial data relating to the efficacy and safety of pegcetacoplan in the treatment of GA secondary to age-related macular degeneration.
Impact of Training about Knowledge, Attitude and Practice of Hepatitis B infection and its Vaccination among Healthcare Professionals in a Tertiary Care Hospital of Northern Gujarat
Authors: Solanki Roli , Gaur Bhumika , Shah Parul D.
Published: June 2023

Hepatitis B is the most prevalent infection and a global concern that affects a large population. Healthcare workers (HCWs) are at higher risk of developing the disease, because of their regular contact with blood and body fluids. Objective of the study was to analyze all HCWs Knowledge, Attitude, and Practice (KAP) concerning hepatitis B infection and its vaccination, as well as the impact of educational training among them. A cross-sectional KAP study was done at a tertiary care hospital using a self structured questionnaire survey regarding hepatitis B infection and its vaccination among 156 HCWs. A short educational PowerPoint presentation (PPT) was given to them, followed by the same questionnaire survey. Pre and post-intervention data were collected to evaluate the effects of training on all HCWs. A Pre-assessment revealed that HCWs had inadequate KAP regarding Hepatitis B infection and vaccination. Ward attendants demonstrated the lowest grades in knowledge and practice and were identified as being at the highest risk. The instructional PPT intervention implemented in the study was proven to be highly effective. The results indicated a significant increase in knowledge and a favorable shift in the attitude towards hepatitis B infection and its vaccination among HCWs. Improvement in knowledge and attitude among all three types of HCW were extremely statistically significant after educational PPT presentation. Hence, this study recommends that increasing awareness of HBV infection and prevention through orientation and educational training, as well as routine tests and immunizations, will be beneficial.
Power Saving Mechanism for Streetlight by using IoT
Authors: Patil Pratima H.
Published: June 2023

Abstract: There have been a predetermined number of brilliant roads in save social orders, and throughout the course of recent many years, streetlights and the executive’s guideline have been moderately basic. In any case, as the world has turned into a more prosperous local area and as urbanization has expanded, the quantity of savvy social orders in present day urban communities has expanded quickly. Consequently, it became difficult to regulate and maintain street lights in smart cities and societies. In addition, it is thought to be the first generation of the original street light control, which was inefficient and a waste of personnel. Right now, streetlights control a large part of the metropolitan climate just through manual control, by means of a control switch introduced inevery streetlight. A lot of electrical energy is lost.
Build a DC to AC Inverter Circuit with IOT Based Load Monitoring
Authors: Vidhate Prof. K. D.
Published: June 2023

Abstract: The boost inverter or boost DC-AC converter is a new voltage source inverter (VSI) that is suggested in this research. The novel inverter topology's key feature is that, depending on the instantaneous duty cycle, it produces an AC output voltage that is greater than the DC input voltage. This characteristic is not present in the conventional VSI, which consistently generates an AC output instantaneous voltage lower than the DC input voltage. A sliding mode controller is suggested to optimize the boost inverter dynamics while guaranteeing proper functioning under any working circumstance. The primary benefit of sliding mode control over traditional control strategies is its resistance to changes in plant parameters, which results in invariant dynamics and steady-state response in in the best scenario. This study covers operation, analysis, control technique, and experimental outcomes. When an AC voltage greater than the DC link voltage is required, the new inverter is designed to be employed in UPS and AC driver systems without the requirement for a second power conversion stage
Early Stage Liver Disease Prediction using Image Processing
Authors: Kumar Dr. K Saravana
Published: June 2023

Abstract: Liver diseases have become increasingly common due to sedentary lifestyles and lack of physical activity, particularly in urban areas and metropolitan cities. This has resulted in millions of deaths every year, with liver cancer being a major contributor. However, inaccurate detection of liver tumors has led to many fatalities. Medical image segmentation is a challenging task when it comes to detecting liver tumors in CT images. Therefore, this project aims to improve the accuracy of tumor detection and segmentation using various image processing techniques, such as pre-processing, enhancement, and clustering algorithms. Early detection is critical in preventing liver cancer fatalities, and this project focuses on improving classification performance to aid in early detection. In this paper, we will describe the steps taken to select the best model and develop a necessary system for predicting liver disease.
Emotion Detection using Machine Learning
Authors: Sharma Chirag
Published: June 2023

Abstract: In this article, a machine learning algorithm is used to identify human emotions. The method will provide a detection precision of 87%. Three separate algorithms will have good accuracy thanks to this. Using a person's facial expression as a base, it records them. One of the most disruptive advances of the past ten years has been the development of machine learning. It has a big impact on reliability and accurate prediction.
Skill Verification System using Ethereum
Authors: Chugh Mr. Amit , Rana Sharad , Banga Somya , Sharma Ujjwal , Bhardwaj Vishal
Published: June 2023

Abstract: Verifying skills is one of the major challenges in hiring new personnel. Companies and academia occasionally struggle to identify a candidate's talents because the credentials abilities that a candidate claims are not immediately verifiable and expensive for examine. For tamper-proof data storage, Blockchains have been proposed in the literature and decentralized talent verification. However, the majority of these schemes center on storing credentials are issued through regular universities for the blockchain. From several solutions that take system of certification itself into consideration, issues like numerous times, issues like (a) scaling with a small staff, (b) homogeneity of scores across numerous evaluators, or (c) extracting sincere effort from the evaluators are unaddressed. We suggest SkillVio, a blockchain-based platform that takes into account the above listed problems. and provide a number of enticing traits. As payment from platform users, such as test takers and employers, the network rewards graders with tokens.
Power Generation using Gym Machine
Authors: Pandey Amit Kumar , Prajapati Deepak , Raj Abhijeet , Singh Akhand Pratap , Pandey Ved Prakash
Published: June 2023

Abstract: Renewable energy sources have become increasingly important as conventional sources deplete. This project involves a gym machine that harnesses power from human users to function both as an exercise machine and power generator. The machine's reciprocating motion is converted into rotary motion using a flywheel arrangement, which is then increased via a gear box, allowing for the generation of electrical energy using an alternator. The power generated through this pull-up/pull-down method is highly efficient, as 95% of the exerted effort is converted into energy. This system serves two purposes by creating resistance in the movement of the forearm and simultaneously generating power from this motion. This project is a creative and innovative way to utilize renewable energy sources while also promoting exercise and physical fitness.
Skin Cancer Detection using Image Processing
Authors: Jadhav Prof. Rupali , Kale Rushiraj , Kadam Shubham , Gund Tushar , Jadhav Shreyas
Published: June 2023

Abstract: Early detection of melanoma, the most dangerous form of skin cancer, is crucial for effective treatment. Melanoma has a higher propensity to metastasize to other parts of the body if not identified and treated promptly. In recent years, non-invasive medical computer vision and medical image processing techniques have emerged as valuable tools in clinical diagnosis for various diseases, including melanoma. These techniques enable automatic image analysis, facilitating accurate and efficient evaluation of skin lesions. The study follows a systematic approach, involving the collection of a dermo image database and preprocessing steps such as segmentation using thresholding. Statistical feature extraction methods, including gray level cooccurrence matrix (GLCM), glam asymmetry, border analysis, color assessment, and diameter calculation, are utilized. Principal component analysis (PCA) is employed for feature selection to reduce dimensionality. A total dermo copy score is calculated, followed by classification using a convolutional neural network (CNN). The results indicate an impressive classification accuracy of 92.1%.
Blockchain Based E-Voting System (Review)
Authors: Bhise Rasika , Khopade Tejas , Zine Kshitija , Salunke Shriram , Shelke Dr. Priya
Published: June 2023

Abstract: New opportunities to create new kinds of digital services are being provided by blockchain. Although study on the subject is still in its early stages, it has largely concentrated on the technological and legal difficulties rather than making use of this innovative idea and developing improved digital services. In this study, we assess a distributed E-voting system implementation using block-chain as a service. The study offers a novel block-chain based E-voting system that tackles some of the drawbacks of current systems and assesses some of the well-known blockchain frameworks in order to build a block-chain based E-voting system. It has long been challenging to develop a secure electronic voting system that maintains the fairness and privacy of paper ballots while providing the transparency and flexibility given by electronic systems in present voting schemes. Through the explanation of a case study, including the election process and the implementation of a blockchain-based application, which increases security and lowers the cost of hosting a national election, we specifically assess the potential of technology.