bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of two isolation methods of tobacco-derived extracellular vesicles, their characterization and uptake by plant and rat cells
Authors: Kocholata Michaela , Prusova Michaela , Auer Malinska Hana , Maly Jan , Janouskova Olga
Published: November 2022

Plant extracellular vesicles (pEVs) derived from numerous edible sources gain a lot of attention in recent years, mainly due to the potential to efficiently carry bioactive molecules into mammalian cells. In the present study, we focus on isolation of PDNVs (plant-derived nanovesicles) and pEVs from callus culture and from BY-2 culture of Nicotiana tabacum (tobacco). Tobacco was selected as a source of plant vesicles, as it is commonly used by human, moreover it is a model organism with established techniques for cultivation of explant cultures in vitro. Explant cultures are suitable for the isolation of pEVs in large quantities, due to their fast growth in sterile conditions. As the efficiency of isolation methods varies, we were comparing two methods of isolation. We evaluated biophysical and biochemical properties of plant vesicles, as well as differences between isolates. We encountered difficulties in the form of vesicles aggregation, which is often described in publications focused on mammalian nanovesicles. In an effort to prevent vesicle aggregation, we used trehalose in different stages of isolation. We show tobacco-derived vesicles successfully enter tobacco and mesenchymal cell lines. We observed that tobacco-nanovesicles isolated by different methods incorporated fluorescent dye with different efficiency. The results of our study show tobacco-derived vesicles isolated by various isolation methods are able to enter plant, as well as mammalian cells.
The diagnostic and prognostic potential of the EGFR/MUC4/MMP9 axis in glioma patients
Authors: Quesnel Agathe , Coles Nathan , Polvikoski Tuomo M. , Karagiannis George S. , Angione Claudio , Islam Meez , Khundakar Ahmad A. , Filippou Panagiota S.
Published: November 2022

Glioblastoma is the most aggressive form of brain cancer, presenting poor prognosis despite current advances in treatment. There is therefore an urgent need for novel biomarkers and therapeutic targets. Interactions between mucin 4 (MUC4) and the epidermal growth factor receptor (EGFR) are involved in carcinogenesis, and may lead to matrix metalloproteinase-9 (MMP9) overexpression, exacerbating cancer cell invasiveness. In this study, the role of MUC4, MMP9, and EGFR in the progression and clinical outcome of glioma patients was investigated. Immunohistochemistry (IHC) and immunofluorescence (IF) in fixed tissue samples of glioma patients were used to evaluate the expression and localization of EGFR, MMP9, and MUC4. Kaplan–Meier survival analysis was also performed to test the prognostic utility of the proteins for glioma patients. The protein levels were assessed with enzyme-linked immunosorbent assay (ELISA) in serum of glioma patients, to further investigate their potential as non-invasive serum biomarkers. We demonstrated that MUC4 and MMP9 are both significantly upregulated during glioma progression. Moreover, MUC4 is co-expressed with MMP9 and EGFR in the proliferative microvasculature of glioblastoma, suggesting a potential role for MUC4 in microvascular proliferation and angiogenesis. The combined high expression of MUC4/MMP9, and MUC4/MMP9/EGFR was associated with poor overall survival (OS). Finally, MMP9 mean protein level was significantly higher in the serum of glioblastoma compared with grade III glioma patients, whereas MUC4 mean protein level was minimally elevated in higher glioma grades (III and IV) compared with control. Our results suggest that MUC4, along with MMP9, might account for glioblastoma progression, representing potential therapeutic targets, and suggesting the ‘MUC4/MMP9/EGFR axis’ may play a vital role in glioblastoma diagnostics.
Modeling and characteristic analysis of roadway profile under the influence of multiple factors
Authors: Liu Zhixiang , Zou Kang , Xie Miao , Xie Chunxue , Sun Zhan
Published: November 2022

Considering that the movement trajectory of roadheader cutting head directly affects the surface morphology characteristics of roadway forming, the creation mechanism of roadway contour obtained by cutting head cutting roadway is analyzed. The robot kinematics analysis method was used to determine the coordinates of the roadheader cutting head in the roadway space coordinate system, and the mathematical model of the cutting head cutting the roadway contour was constructed. Through numerical calculation, the differences of roadway morphology characteristics formed by three different types of cutting heads are analyzed. The orthogonal experiment was designed, and the regression equation under multiple factors was solved with the experimental results. The influence of cutting feed rate, cutting Angle, cutting head radius and cutting head cone Angle on the morphology characteristics of cutting surface was analyzed by regression calculation and theoretical calculation. The research results show that the roadway surface obtained by "spherical crown + cylinder" cutting head is the most uneven, and the roadway surface obtained by "spherical crown + cone + cylinder" cutting head is the most flat. With the decrease of cutting lifting Angle, cutting feed, cutting head cone Angle and the increase of cutting head crown radius, the smoothness of roadway obtained by cutting is higher.
Exactly solving the Kitaev chain and generating Majorana-zero-modes out of noisy qubits
Authors: Rančić Marko J.
Published: November 2022

Majorana-zero-modes (MZMs) were predicted to exist as edge states of a physical system called the Kitaev chain. MZMs should host particles that are their own antiparticles and could be used as a basis for a qubit which is robust-to-noise. However, all attempts to prove their existence gave inconclusive results. Here, the Kitaev chain is exactly solved with a quantum computing methodology and properties of MZMs are probed by generating eigenstates of the Kitev Hamiltonian on 3 noisy qubits of a publicly available quantum computer. After an ontological elaboration I show that two eigenstates of the Kitaev Hamiltonian exhibit eight signatures attributed to MZMs. The results presented here are a most comprehensive set of validations of MZMs ever conducted in an actual physical system. Furthermore, the findings of this manuscript are easily reproducible for any user of publicly available quantum computers, solving another important problem of research with MZMs—the result reproducibility crisis.
Using model explanations to guide deep learning models towards consistent explanations for EHR data
Authors: Watson Matthew , Awwad Shiekh Hasan Bashar , Al Moubayed Noura
Published: November 2022

It has been shown that identical deep learning (DL) architectures will produce distinct explanations when trained with different hyperparameters that are orthogonal to the task (e.g. random seed, training set order). In domains such as healthcare and finance, where transparency and explainability is paramount, this can be a significant barrier to DL adoption. In this study we present a further analysis of explanation (in)consistency on 6 tabular datasets/tasks, with a focus on Electronic Health Records data. We propose a novel deep learning ensemble architecture that trains its sub-models to produce consistent explanations, improving explanation consistency by as much as 315% (e.g. from 0.02433 to 0.1011 on MIMIC-IV), and on average by 124% (e.g. from 0.12282 to 0.4450 on the BCW dataset). We evaluate the effectiveness of our proposed technique and discuss the implications our results have for both industrial applications of DL and explainability as well as future methodological work.
Multi-decadal oscillations of surface temperatures and the impact on temperature increases
Authors: Kalicinsky Christoph , Koppmann Ralf
Published: November 2022

The last IPCC assessment report indicated that natural climate variability could temporarily amplify or obscure anthropogenic climate change on decadal time scales. Here we analyse global mean surface temperatures in terms of such long-period variations. We find two main oscillations, a strong oscillation with a period of about 70 years and an amplitude of about 0.09 K and a quasi-bidecadal oscillation with an amplitude of about 0.06 K. The strong oscillation shows large hemispheric differences. In the Northern hemisphere the period is longer and the amplitude is larger (about 82 years and 0.18 K) compared to the Southern hemisphere (about 47 years and 0.065 K). No obvious hemispheric differences are observed for the quasi-bidecadal oscillation. Such long-period oscillations can strengthen or weaken the temperature increase if the oscillation positively or negatively adds to the underlying long-term trend.
Laser-optics-based method to suppress Mikania micrantha growth
Authors: Lan Yu-Pin
Published: November 2022

Mikania micrantha is an exotic and aggressive species that can reproduce asexually and sexually through its germinative stem and its featherlike seeds. Present weeding methods cannot effectively or economically control the spread of Mikania micrantha. In this article, we propose a method to suppress the growth and spread of Mikania micrantha by applying a high-energy laser beam to penetrate its stem. The threshold penetrating optical intensity is 3.1 W/mm2. To optimize the damage to the inner tissue of the stem, which includes the vascular bundle and medulla for transporting organic nutrients, water, and inorganic salt, the absorption spectrum of the tissue and laser beam size are analyzed. According to the absorption spectrum of the tissue and growth mechanism of Mikania micrantha, a 455 nm blue laser is used as an irradiated light source. A single beam with two different beam sizes or two laser beams with the same beam size is used to optimize the stem damage. By the time the cumulative energy reaches 15 Joules for a single laser beam with dimensions of 0.81 mm × 0.74 mm, the inner tissue will be damaged 97.5%. We perform laser irradiation on the fresh Mikania micrantha grown hydroponically, with the result that all samples withered in 30 days. Therefore, using the method before the flowering season of Mikania micrantha can effectively inhibit its reproduction.
Delivery of the reduced form of vitamin K2(20) to NIH/3T3 cells partially protects against rotenone induced cell death
Authors: Toki Erina , Goto Shotaro , Setoguchi Shuichi , Terada Kazuki , Watase Daisuke , Yamakawa Hirofumi , Yamada Ayano , Koga Mitsuhisa , Kubota Kaori , Iwasaki Katsunori , Karube Yoshiharu , Matsunaga Kazuhisa , Takata Jiro
Published: November 2022

Mitochondria generate energy through the action of the electron transport chain (ETC) and ATP synthase. Mitochondrial malfunction can lead to various disorders, including neurodegenerative diseases. Several reports have shown that menaquinone-4 (MK-4, vitamin K2(20)), a safe drug for osteoporosis, may improve mitochondrial function. Here, we hypothesized that the efficient delivery of menahydroquinone-4 (MKH), an active form of MK-4, could exert a supporting effect. We verified the effects of MKH delivery on mitochondrial dysfunction by using MK-4 and MKH ester derivatives in NIH/3T3 mouse fibroblast cells treated with mitochondrial inhibitors. MK-4 and MKH derivatives suppressed cell death, the decline in mitochondrial membrane potential (MMP), excessive reactive oxygen species (ROS) production, and a decrease in intrinsic coenzyme Q9 (CoQ9) induced by rotenone (ROT, complex I inhibitor). MK-4 and MKH derivatives delivered MKH to NIH/3T3 cells, acting as an effective MKH prodrug, proving that the delivered MKH may reflect the mitigation effects on ROT-induced mitochondrial dysfunction. MKH prodrugs are also effective against 3-nitropropionic acid (3-NP, complex II inhibitor) and carbonyl cyanide-m-chlorophenylhydrazone (CCCP, uncoupler)-induced cell death. In conclusion, MKH delivery may mitigate mitochondrial dysfunction by maintaining MMP, ROS, and CoQ9, indicating that MKH prodrugs may be good candidates for treating mitochondrial disorders.
Retrospective analysis and prospective validation of an AI-based software for intracranial haemorrhage detection at a high-volume trauma centre
Authors: Zia Adil , Fletcher Calvin , Bigwood Shalini , Ratnakanthan Prasanna , Seah Jarrel , Lee Robin , Kavnoudias Helen , Law Meng
Published: November 2022

Rapid detection of intracranial haemorrhage (ICH) is crucial for assessing patients with neurological symptoms. Prioritising these urgent scans for reporting presents a challenge for radiologists. Artificial intelligence (AI) offers a solution to enable radiologists to triage urgent scans and reduce reporting errors. This study aims to evaluate the accuracy of an ICH-detection AI software and whether it benefits a high-volume trauma centre in terms of triage and reducing diagnostic errors. A peer review of head CT scans performed prior to the implementation of the AI was conducted to identify the department’s current miss-rate. Once implemented, the AI software was validated using CT scans performed over one month, and was reviewed by a neuroradiologist. The turn-around-time was calculated as the time taken from scan completion to report finalisation. 2916 head CT scans and reports were reviewed as part of the audit. The AI software flagged 20 cases that were negative-by-report. Two of these were true-misses that had no follow-up imaging. Both patients were followed up and exhibited no long-term neurological sequelae. For ICH-positive scans, there was an increase in TAT in the total sample (35.6%), and a statistically insignificant decrease in TAT in the emergency (− 5.1%) and outpatient (− 14.2%) cohorts. The AI software was tested on a sample of real-world data from a high-volume Australian centre. The diagnostic accuracy was comparable to that reported in literature. The study demonstrated the institution’s low miss-rate and short reporting time, therefore any improvements from the use of AI would be marginal and challenging to measure.
Observation of hapten-induced sensitization responses for the development of a mouse skin sensitization test, including the elicitation phase
Authors: Kamata Ryo , Okawa Yukiko , Hamaguchi Yuto , Tabata Soma , Terasaki Masanori , Takeda Kazuki
Published: November 2022

The only official method that can detect the skin sensitizing potential of chemicals, including the elicitation response, is the OECD test guideline (TG) 406. However, this guideline uses guinea pigs, which requires complex procedures. Since a simple and complete test method for evaluating skin sensitization is needed, especially for mechanistic studies of skin sensitization, this study confirmed the reactivity of mice to skin sensitizing substances. We set up a protocol involving one induction exposure of the test substance to the back skin, followed by three challenge exposures to the auricle (Protocol 2), and compared their skin sensitization responses with the results of two exposures to the auricle and back skin every 2 weeks (Protocol 1) and a local lymph node assay (TG442B). A hapten 2,4-dinitrofluorobenzene caused significant auricular thickening, skin inflammation, and enlarged auricular lymph nodes in Protocols 1 and 2. These changes were more pronounced in Protocol 2. Plasma IgE and IgG1 and gene expression of IL4, IFNγ, and perforin were significantly increased in Protocol 2. Cell proliferation in the auricular lymph nodes was observed in both protocols as in TG442B. These results indicate that Protocol 2 can be a good candidate for a relatively simple skin sensitization test.
A High-level Analysis of the Environmental Sustainability of Biomass-derived Fuels
Authors: Fox James Alistair
Published: November 2022

In this chapter, fundamental concepts based on conservation of mass and conservation of energy are applied to answer two main questions: firstly, how environmentally sustainable are biomass-to-liquid processes when taking carbon emissions from the process into account, and secondly, what would it take to construct a completely sustainable biomass-to-liquid process? The analysis in this chapter determines that a process that produces 140 000 barrels of liquid fuel a day would require that around 80 000 km2 of forest be cultivated in order to achieve complete carbon neutrality. While this is a very large area of land, it is still comparable to the largest farms that currently exist. If the analysis is extended to achieving carbon neutrality for the entire planet's oil usage, 14 million km2 of land is needed for energy crops. However, only 10 million km2 of land is actually available for energy crops. Biofuels, on their own, are therefore not going to solve the problem of environmental sustainability although they are definitely part of the solution. In contrast, there is no chance of environmental sustainability if the current over-reliance on fossil fuels continues. Biomass can capture at least some of the carbon emissions from processes or other human activities, which is better than not capturing any of the emitted carbon dioxide at all.
Fischer–Tropsch Synthesis Reactors
Authors: Lu X. , Hildebrandt D.
Published: November 2022

Reactors are key components in large-scale commercial projects where reactions convert feed to product. Fischer–Tropsch synthesis converts small molecules (CO and H2) into a wide range of hydrocarbons over a solid catalyst with some degree of tunable selectivity. The reaction products include petrol, diesel and wax. A reactor is not only a vessel that contains the catalyst, but it also determines the interactions between the catalyst, the reaction kinetics and the process streams. The primary goal when designing and operating a reactor is to create a suitable environment for the catalyst in order to sustain the desired reaction(s). Therefore, a good reactor design always considers the thermodynamics, kinetics, mass transfer and heat transfer related to the reaction, as well as the catalyst, the flow and mixing required in the reactor and the reactor type. Furthermore, the design must consider the possible risks during start-up, normal operation and catalyst regeneration, from both the engineering perspective, as well as with regard to the science behind the engineering. In this chapter, reactors that have been used in commercial FT projects are introduced, and their characteristics are discussed. The special requirements for reactors used in biomass-to-liquid plants are described, and current developments and potential future applications are introduced and discussed.
Visualizing the distribution of curcumin in the root of Curcuma longa via VUV-postionization mass spectrometric imaging
Authors: Nie Wuyi , Lu Qiao , Hu Tao , Xie Min , Hu Yongjun
Published: November 2022

Curcumin is a dietary spice and coloring agent widely used in food and herbal medicine.
Study of insecticide translocation in coconut palm trees after using pressurized endotherapy
Authors: Ferreira Jordana Alves , Almeida Gabriela Brito , Lins Paulo Manoel Pontes , Tavares Marley Mendonça , Farias Samuel C. Cohen , Queiroz Sonia C. N.
Published: November 2022

Alternative techniques for applying agricultural products, such as pressurized endotherapy, have shown promise in pest and disease control in coconut palms (Cocos nucifera Linn.).
NO released via both a Cu-MOF-based donor and surface-catalyzed generation enhances anticoagulation and antibacterial surface effects
Authors: Zhang Jianwen , Ke Xianlan , Huang Maotao , Pei Xinyu , Gao Shuai , Wu Dimeng , Chen Junying , Weng Yajun
Published: November 2022

The anticoagulation and antibacterial functions of implant and interventional catheters during indwelling will determine their success or failure.
Organic and quantum dot hybrid photodetectors: towards full-band and fast detection
Authors: Liu Junwei , Wang Jingjing , Xian Kaihu , Zhao Wenchao , Zhou Zhihua , Li Shaojuan , Ye Long
Published: November 2022

In this Highlight, we outlined the recent progress of organic/quantum dot hybrid photodetectors, with the aim of further broadening the response range and enhancing the detection performance.
Electron transport via tyrosine-doped oligo-alanine peptide junctions: role of charges and hydrogen bonding
Authors: Guo Cunlan , Gavrilov Yulian , Gupta Satyajit , Bendikov Tatyana , Levy Yaakov , Vilan Ayelet , Pecht Israel , Sheves Mordechai , Cahen David
Published: November 2022

A way of modulating the solid-state electron transport (ETp) properties of oligopeptide junctions is presented by charges and internal hydrogen bonding, which affect this process markedly.
Three-centre electron sharing indices (3c-ESIs) as a tool to differentiate among (an)agostic interactions and hydrogen bonds in transition metal complexes
Authors: García-Rodeja Yago , Feixas Ferran , Matito Eduard , Solà Miquel
Published: November 2022

The agostic bond plays an important role in chemistry. Here we propose the use of three-centre electron sharing indices to classify M⋯H–X (X = C, N) interactions among agostic, anagostic, and hydrogen bonds.
iClick synthesis of network metallopolymers
Authors: Shen Yu-Hsuan , Ghiviriga Ion , Abboud Khalil A. , Schanze Kirk S. , Veige Adam S.
Published: November 2022

Described is an approach to preparing the first iClick network metallopolymers with porous properties.
Photocatalytic degradation of methylene blue and dye mixture using indium-doped CaWO4 synthesized by sonochemical and microwave-assisted hydrothermal methods
Authors: Nunes T. B. O. , Teodoro M. D. , Bomio M. R. D. , Motta F. V.
Published: November 2022

Synthesis methods and characterization of indium-doped calcium tungstate particles.
Bi-functional ionic liquids facilitate liquid-phase exfoliation of porphyrin-based covalent organic frameworks in water for highly efficient CO2 photoreduction
Authors: Guo Yingying , Zhang Qian , Gao Shuaiqi , Wang Huiyong , Li Zhiyong , Qiu Jikuan , Zhao Yang , Liu Zhimin , Wang Jianji
Published: November 2022

A green, high yield and scalable strategy to exfoliate covalent organic framework powders using bi-functional ionic liquids in water was developed under ambient conditions.
TiO2/ZIF-67 nanocomposites synthesized by the microwave-assisted solvothermal method: a correlation between the synthesis conditions and antimicrobial properties
Authors: Campos Raquel Dantas , Menezes de Oliveira André Luiz , Rostas Arpad Mihai , Kuncser Andrei Cristian , Negrila Constatin Catalin , Galca Aurelian-Catalin , Félix Camila , Castellano Lúcio , da Silva Fausthon Fred , dos Santos Iêda Maria Garcia
Published: November 2022

Zeolitic imidazole frameworks (ZIFs) and TiO2 based composites have recently attracted interest to control pathogenic microorganism growth.
Highly efficient silica coated perovskite nanocrystals with the assistance of ionic liquids for warm white LEDs
Authors: Xu Yanqiao , Hu Xiaobo , Tang Huidong , Hu Qing , Wang Sanhai , Chen Ting , Zhang Xiaojun , Jiang Weihui , Wang Lianjun , Jiang Wan
Published: November 2022

A novel and efficient silica encapsulation method with the assistance of a multifunctional ionic liquid is proposed for the preparation of highly luminescent and stable CsPbBr3@SiO2 NCs.
Synthetic and computational investigation of neighboring group participation by a nucleophilic disulfide bond
Authors: Yamamoto Takuhei , Fukuta Koki , Kariya Yuki , Matsuura Taiki , Hagiwara Hiroaki , Uno Bunji , Esaka Yukihiro
Published: November 2022

Neighboring group participation by a disulfide bond.
Lawesson's reagent promoted deoxygenation of azlactones for the syntheses of 2,4-disubstituted thiazoles
Authors: Yin Gaofeng , Wang Xiaodong , Wang Yuqing , Shi Tao , Zeng Yaofu , Wang Yuying , Peng Xue , Wang Zhen
Published: November 2022

A new method for the straightforward syntheses of 2,4-disubstituted thiazoles from azlactonesviadeoxygenation with Lawesson's reagent has been developed.
Precision syntheses of poly(NIPAM-alt-HEMA) and effects of the alternating sequence on thermoresponsive behaviors in water
Authors: Xu Xiaoyan , Shibata Kentaro , Ouchi Makoto
Published: November 2022

An alternating copolymer of 2-hydroxyethyl methacrylate and N-isopropylacrylamide was synthesized via cyclopolymerization of a divinyl monomer and aminolysis transformation for studies of the sequence-dependent thermal responsiveness in water.
Data-driven ligand field exploration of Fe(iv)–oxo sites for C–H activation
Authors: Jones Grier M. , Smith Brett A. , Kirkland Justin K. , Vogiatzis Konstantinos D.
Published: November 2022

We have explored the ligand topology of high-valent Fe(iv)–oxo complexes for screening a large molecular database with machine learning.
Diversified two-electron reduction for trivalent scandium complexes with arene ligands
Authors: Zhu Miaomiao , Li Tianyu , Chai Zhengqi , Wei Junnian , Lv Ze-Jie , Zhang Wen-Xiong
Published: November 2022

A series of reduced naphthalene and anthracene complexes of mononuclear scandium were prepared, which undergo diversified two-electron redox reactions with unsaturated molecules.
Potent antibacterial activity of MXene–functionalized graphene nanocomposites
Authors: Salmi Mohammed Sadey , Ahmed Usman , Aslfattahi Navid , Rahman Saidur , Hardy John George , Anwar Ayaz
Published: November 2022

(A) SEM and (B) HRTEM images of 75% F graphene:25% Ti3C2Tx nanocomposite.
Improvement and regeneration of Co–B amorphous alloy nanowires for the selective hydrogenation of cinnamaldehyde
Authors: Mo Min , Tang Jiansheng , Zou Lijun , Xun Youyi , Guan Hongru
Published: November 2022

Co–B amorphous alloy nanowires exhibited the improvement of catalytic hydrogenation activity and cycling life by plasma treatment.
Autocatalytic methylthiomethylation of carboxylic acid/phenol involving the formation of DMSO enolate: convenient synthesis of methylthiomethyl ester/ether
Authors: Liu Hongshi , Wang Enhua , Yang Juan , Peng Mei , Gao Ming , Jiang Yangming , Hu Enming , Liang Guangyan , Yang Lishou , Yang Xiaosheng
Published: November 2022

This work reported a simple and practical protocol for the preparation of methylthiomethyl (MTM) esters/ethers directly from carboxylic acid/phenol and dimethylsulfoxide (DMSO) as solvent and methylthiomethyl source.
A new process for the recovery of palladium from a spent Pd/TiO2 catalyst through a combination of mild acidic leaching and photodeposition on ZnO nanoparticles
Authors: Muscetta Marica , Pota Giulio , Vitiello Giuseppe , Al Jitan Samar , Palmisano Giovanni , Andreozzi Roberto , Marotta Raffaele , Di Somma Ilaria
Published: November 2022

A combination of leaching and sacrificial photocatalytic deposition was proposed to recover palladium. The recycling of the photocatalyst resulted in a practical method for reducing wastes generated during the process.
Tuning reactivity in trimetallic dual-atom alloys: molecular-like electronic states and ensemble effects
Authors: Zhang Shengjie , Sykes E. Charles H. , Montemore Matthew M.
Published: November 2022

Creating dual-atom active sites in host metals allows tuning of chemical properties through electronic effects and ensemble effects. In particular, some dual-atom alloys feature molecular-like electronic states.
Novel lanthanide nanoparticle frameworks for highly efficient photoluminescence and hypersensitive detection
Authors: Tong Yuan-Jun , Yu Lu-Dan , Li Nan , Shen Minhui , Peng Xiaoru , Yang Huangsheng , Ye Yu-Xin , Zhu Fang , Pawliszyn Janusz , Xu Jianqiao , Ouyang Gangfeng
Published: November 2022

Robust lanthanide cluster frameworks are fabricated by in situ assembly of lanthanide clusters into the confined spaces of covalent organic frameworks, which enables the discrimination of methinehalides and detection of uranyl ions.
Influence of central sidechain on self-assembly of glycine-x-glycine peptides
Authors: Thursch Lavenia J. , Lima Thamires A. , O’Neill Nichole , Ferreira Fabio F. , Schweitzer-Stenner Reinhard , Alvarez Nicolas J.
Published: November 2022

Low molecular weight gelators (LMWGs) are the subject of intense research for a range of biomedical and engineering applications.
Compression of colloidal monolayers at liquid interfaces: in situ vs. ex situ investigation
Authors: Kuk Keumkyung , Abgarjan Vahan , Gregel Lukas , Zhou Yichu , Carrasco Fadanelli Virginia , Buttinoni Ivo , Karg Matthias
Published: November 2022

The assembly of colloidal particles at liquid interfaces is a versatile procedure to create microstructured monolayers. Our in situ small-angle light scattering of the monolayer provides new insights into the interfacial assembly behavior.
Engineering g-C3N4 composited Fe-UIO-66 to in situ generate robust single-atom Fe sites for high-performance PEMFC and Zn–air battery
Authors: An Lu , Chi Bin , Deng Yingjie , Chen Chao , Deng Xiaohua , Zeng Ranjie , Zheng Yuying , Dang Dai , Yang Xu , Tian Xinlong
Published: November 2022

Developing an efficient and robust electrocatalyst for the sluggish oxygen reduction reaction (ORR) in PEMFC and Zn–air battery is imperatively desirable and challenging.
EXAFS evidence for the spin–phonon coupling in the monoclinic PrNiO3 nickelate perovskite
Authors: Rodrigues J. E. , Rosa A. D. , López-Sánchez J. , Sebastiani-Tofano E. , Nemes N. M. , Martínez J. L. , Alonso J. A. , Mathon O.
Published: November 2022

The structural changes in PrNiO3 around the Ni atoms are studied by XAS. The spin–phonon coupling and the softening of the lattice vibrations are observed. EXAFS is suitable for exploring the coupling between the spins and phonons.
The relationship between islet β-cell function and metabolomics in overweight patients with Type 2 diabetes
Authors: Lv You , Zheng Yuanyuan , Zhao Xue , Li Zhuo , Wang Guixia
Published: November 2022

A cross-sectional study was performed using metabolomics in overweight patients with Type 2 diabetes (T2D) at different stages of the disease. We aimed to identify potential metabolites for assessing islet β-cell function in order to investigate the correlation between islet β-cell dysfunction and metabolite changes in overweight patients with T2D. We selected 60 overweight adults (24 ≤ body mass index [BMI] < 28 kg/m2) with T2D who had been admitted to our hospital. The participants were equally divided into three groups according to disease duration: H1 (duration ≤ 5 years), H2 (5 years < duration ≤ 10 years), and H3 (duration > 10 years). Questionnaires, physical examinations, laboratory tests, and imaging studies were administered to all participants. The modified homeostasis model of assessment (HOMA) index was calculated using fasting C-peptide levels, and metabolite assays were performed using mass spectrometry. The results showed that HOMA-β and visceral fat area (VFA) were negatively correlated with diabetes duration. The VFA was positively correlated with arginine, cysteine, methionine, proline, and succinyl/methylmalonylcarnitine levels. The HOMA-β was negatively correlated with the serine and tetradecanoyldiacylcarnitine levels, and positively correlated with the aspartic acid, cysteine, homocysteine, piperamide, proline, and valine levels. The HOMA-IR was negatively correlated with hydroxypalmitoylcarnitine levels and positively correlated with the myristoylcarnitine levels. Thus, at different stages of T2D progression in overweight patients, serine, aspartic acid, cysteine, homocysteine, piperamide, proline, valine, and tetradecanoyldiacylcarnitine may be associated with HOMA-β and represent potential novel biomarkers for evaluating islet β-cell function.
Quantifying muscle blood flow: a transformative breakthrough in the science of human exercise physiology
Authors: Olson Thomas P. , Smith Joshua R. , Curry Timothy B.
Published: November 2022

Over 50 years ago, John Wahren and Lennart Jorfeldt published a manuscript in Clinical Science where they detailed a series of studies of leg blood flow during exercise. They used a novel approach to indicator dye dilution: continuous arterial infusions of dye using venous samples. This technique allowed them to describe for the first time the fundamental relationships between large muscle group exercise, muscle blood flow, and pulmonary and muscle oxygen uptake. They also defined mechanical efficiency, a key measurement of muscle function. This paper formed the basis for research into muscle blood flow and exercise in health and disease and continued to be cited by modern research. In this commentary, we describe the innovations they made, the key observations that came out of their results, and the importance of this manuscript to current research.
Artificial cell design: reconstructing biology for life science applications
Authors: Ghosh Basusree
Published: November 2022

Artificial cells are developed to redesign novel biological functions in a programmable and tunable manner. Although it aims to reconstitute living cell features and address ‘origin of life' related questions, rapid development over the years has transformed artificial cells into an engineering tool with huge potential in applied biotechnology. Although the application of artificial cells was introduced decades ago as drug carriers, applications in other sectors are relatively new and could become possible with the technological advancement that can modulate its designing principles. Artificial cells are non-living system that includes no prerequisite designing modules for their formation and therefore allow freedom of assembling desired biological machinery within a physical boundary devoid of complex contemporary living-cell counterparts. As stimuli-responsive biomimetic tools, artificial cells are programmed to sense the surrounding, recognise their target, activate its function and perform the defined task. With the advantage of their customised design, artificial cells are being studied in biosensing, drug delivery, anti-cancer therapeutics or artificial photosynthesis type fields. This mini-review highlights those advanced fields where artificial cells with a minimalistic setup are developed as user-defined custom-made microreactors, targeting to reshape our future ‘life'.
Comprehensive configuration strategy of energy storage allocation and line upgrading for distribution networks considering a high proportion of integrated photovoltaics
Authors: Zhang Xiaohui , Wang Liang , Zhang Bo , Li Jia , Pan Yongchao , Zhang Lu , Tang Wei
Published: November 2022

The rapid development of photovoltaics (PVs) and load caused a significant increase in peak loads and peak‐valley differences in rural distribution networks, which require load peak shifting and line upgrading. Large peak‐valley differences also bring challenges on the safe operation of the utility power grid. Considering the integration of a high proportion of PVs, this study establishes a bilevel comprehensive configuration model for energy storage allocation and line upgrading in distribution networks, which can reduce peak loads and peak‐valley differences. In the upper level, a minimum annual planning cost is obtained by developing the installation capacity of centralised energy storage in transformer stations, the installation location and capacity of decentralised energy storage on lines and a scheme of line upgrading. In the lower level, the minimum total annual operation cost of the distribution network is obtained by developing an optimal scheduling for the centralised energy storage in transformer stations and decentralised energy storage on lines. Simulation results show that compared with the conventional energy storage planning strategy, the configuration investment can be reduced by 467.66 million yuan at least with the proposed strategy.
The first look at narrow-line Seyfert 1 galaxies with eROSITA
Authors: Grünwald G. , Boller Th. , Rakshit S. , Buchner J. , Dauser Th. , Freyberg M. , Liu T. , Salvato M. , Schichtel A.
Published: November 2022

We present the first look at the spectral and timing analysis of narrow-line Seyfert 1 galaxies (NLS1s) with the extended ROentgen Survey with an Imaging Telescope Array (eROSITA) on board the Spectrum-Roentgen-Gamma (SRG) mission. The sample of approximately 1200 NLS1s was obtained via a cross-match between the first eROSITA All-Sky Survey (eRASS1) catalogue and the catalogue of spectroscopically selected NLS1s from the twelfth data release of the Sloan Digital Sky Survey (SDSS) DR12. The X-ray spectral analysis is based on a simple power-law fit. The photon index distribution has a mean value of about 2.81 ± 0.03, as expected from previous X-ray studies of NLS1s. Interestingly, it is positively skewed, and about 10% of the sources are located in the super-soft tail of photon indices larger than 4. These sources are of further interest as their source counts run into the X-ray background at values at around 1 keV. We argue that ionised outflows have been detected by eROSITA and may account for some of the extreme spectral steepness, which is supported by correlations found between the photon index and optical outflow parameters. We analysed the intrinsic X-ray variability of the eRASS1 to eRASS3 light curves of the sample but do not find significant variability either during the individual survey scans or between them.
Discontinuous Galerkin approximations to elliptic and parabolic problems with a Dirac line source
Authors: Masri Rami , Shen Boqian , Riviere Beatrice
Published: November 2022

The analyses of interior penalty discontinuous Galerkin methods of any order k for solving elliptic and parabolic problems with Dirac line sources are presented. For the steady state case, we prove convergence of the method by deriving a priori error estimates in the L2 norm and in weighted energy norms. In addition, we prove almost optimal local error estimates in the energy norm for any approximation order. Further, almost optimal local error estimates in the L2 norm are obtained for the case of piecewise linear approximations whereas suboptimal error bounds in the L2 norm are shown for any polynomial degree. For the time-dependent case, convergence of semi-discrete and of backward Euler fully discrete scheme is established by proving error estimates in L2 in time and in space. Numerical results for the elliptic problem are added to support the theoretical results.
An experimental and numerical study on the modelling of fluid flow, heat transfer and solidification in a copper continuous strip casting process
Authors: Mahmoudi Jafar
Published: November 2022

An experimental and “numerical study (first part of this study study) was carried out to investigate the solidification process in a copper continuous strip casting process. The model has been tuned by experimental results (i.e. cooling water flow measurements, temperature measurements and metallographic analysis). Further, the results have been used to study the possibility of improved productivity. In this report (second of the study) the flow pattern of the molten copper during a strip casting process as a manufacturing method has been studied using a full-scale water model. The dynamic similarity between model and real system has been studied. Six different types of inlet system to the mould have been studied: inlet nozzle jets with free stream, submerged nozzle jets, slot-submerged inlet system, semi slot-submerged inlet system, submerged-slot inlet nozzle jets and finally submerged-slot inlet nozzle jets with jet killer. Moreover, the effects of nozzle angle, nozzle diameter, casting speed, tundish adjustment and misalignment of the inlet nozzle jets on the flow pattern have been investigated. The vortex formation and bubble entrainment, depending upon the nozzle configuration, immersion depth and the fluid level in the mould have also been studied. It was found that the slot-submerged inlet nozzle jets with jet killer arrangement showed an obvious improvement of the fluid flow characteristics, yielding better tracer distribution in the flow pattern, lower values of back mixing flow, lower turbulence and lower vortex and recirculation flow.
Bibliotherapy in the Pandemic Time: A Bibliometric Analysis
Authors: Maru Mister Gidion , Rianto Indra , Nur Sahril , Pratasik Stralen
Published: November 2022

This research aims to obtaining the general parametric insights on the productivity and influence of the studies on that fields as the attempt to deal with the impact of the spread of the corona virus particularly to students and their language learning. The inclusion of the language learning is connected with the notion of language as the main ingredient of text(s) selected for bibliotherapy. By relying upon Publish or Perish (PoP) metrics, the analysed data were taken from the articles published within the range from 2020-2022 which are thought to be the period of the emergence and highly spread of Corona Virus. To guide the exact and comprehensive search, seven keywords such as covid, pandemic, students, text, literature, language learning and Indonesia are combined with bibliotherapy as the main topic. The results indicated that globally 148 articles mark the productivity of the research on the bibliotherapy, yet the high impact gain by the combination of bibliotherapy with ‘student, pandemic, and literature’ as shown by the metrics of citation and index. Unfortunately, this global tendency is far different from the Indonesian context which reveals no inquiry yet conducted on the bibliotherapy issue despite the big number of victims and affected covid-19 in this country.
Trust as a Key Factor in Knowledge Transfer and Innovation Capabilities
Authors: Wuryaningrat Nikolas F. , Kindangen Paulus , Paulus Ardianus L.
Published: November 2022

The era of knowledge-based economy has created rapid changes in the business environment. Maintaining a business in that era requires innovation to maintaining its competitiveness. Innovation requires knowledge resources, where knowledge transfer plays an essential role in creating new knowledge that can be utilized to improve innovation capabilities. However, knowledge transfer is considered not a simple process because of the stickiness of knowledge, but on the other hand, knowledge transfer can be regarded as something that can happen instantly. Trust is therefore considered as the factor to strengthening the causality relationship between knowledge transfer and innovation capabilities. This study used a survey approach with Partially Least Square (PLS) data analysis techniques. The respondents in this research are SMEs of the creative industry handicraft sub-sector in the Province of DIY, Bali and North Sulawesi, which are justified as representations of Indonesia. Based on the 201 data collected, it was found that trust significantly moderated the causality relationship between knowledge transfer and innovation capabilities. Hence, knowledge transfers are needed for developing SMEs of the creative industries innovation capabilities which strengthened by the trust.
Study of E-Readiness: Integration of SDGS Indicators in Village Development Planning in Malo District, Bojonegoro Regency
Authors: Ma'ruf Muhammad Farid , T Tauran , Kurniawan Badrudin , Eprilianto Deby Febriyan
Published: November 2022

The government has implemented various digital-based data applications for village development. Unfortunately, the use of this technology by village officials is still a challenge. Using the Strategy, Technology, Organization, People and Environment (STOPE) framework, this research is measuring the E-readiness of the village apparatus in using the Village SDGs data for development planning as well as to explore how the village apparatus is ready to synergize various digital-based applications in village development planning. The concept of E-readiness is the ability of the government and its citizens to take advantage of the potential of information and communication technology in governance process. This research uses the descriptive method. The research was conducted in seven villages in the Malo district, Bojonegoro regency. The results showed that the readiness of village government officials to manage data is promising. Some of the village government Readiness subdomains in the STOPE framework have achieved good results (ready and very ready). However, some sub-domains have not yet reached the ready category in integrating SDGs data in development planning and programs.
Impact of Service Quality and Complaint Management on Customer Satisfaction Case Study from E-Commerce Marketing Client Lazada
Authors: Rohmayati Nita Selvia , Hidayat Rachmad
Published: November 2022

The purpose of this study was to clarify (1) the impact of service quality on Lazada user satisfaction, (2) the impact of complaints handling on Lazada user satisfaction, and (3) the impact of satisfaction of users on the loyalty of Lazada users. The study measures service quality, complaint handling and customer satisfaction as precedent to influence consumer loyalty. The sample for this study was 130 consumers who shopped on Lazada. All data studied were analysed with a structural equation model using the PLS Wrap computer program. The main findings of this study were that the quality of service had a significant positive effect on consumer satisfaction, the handling of complaints also had a significant positive effect on consumer satisfaction and consumer satisfaction and consumer loyalty. It has been shown to produce results that have a positive effect The final conclusions of the consumer retention survey can be recommended as having important management implications. The researchers believe that the approach used in this study can help companies gain insights into the relative contribution of each specific aspect of complaint management to customer satisfaction and retention.
The Effect of Communication Skills of Civil Servant in Public Service on Community Satisfaction
Authors: Rivai Andi Muhammad , Baharuddin Aris , Syarifuddin  , Seppa Yusi Iren , Yusri
Published: November 2022

This study aims to examine the effect of the communication skills of civil servants in public service activities on community satisfaction. This study uses a quantitative method with a causality correlation approach. Communication skills as the dependent variable are measured using the Interpersonal communication skill scale. Community satisfaction in public services as an independent variable is measured using the Community Satisfaction Scale. Respondents in this study are Makassar people who often access or get public services. The data analysis technique used is simple regression analysis and descriptive statistics. The results showed that the communication skills of civil servants in public service activities had a significant effect on people's satisfaction. This finding shows that the communication ability of public service providers is an important thing that must be considered in public services. Therefore, in the future,material on communication skills needs to be integrated into training materials to increase the capacity of civil servants.