bluuebunny/crossref_metadata_2025 huggingface dataset:
Challenges and Opportunities of Intraoperative 3D Ultrasound With Neuronavigation in Relation to Intraoperative MRI
Authors: Bastos Dhiego Chaves De Almeida , Juvekar Parikshit , Tie Yanmei , Jowkar Nick , Pieper Steve , Wells Willam M. , Bi Wenya Linda , Golby Alexandra , Frisken Sarah , Kapur Tina
Published: May 2021

Introduction

Neuronavigation greatly improves the surgeon’s ability to approach, assess and operate on brain tumors, but tends to lose its accuracy as the surgery progresses and substantial brain shift and deformation occurs. Intraoperative MRI (iMRI) can partially address this problem but is resource intensive and workflow disruptive. Intraoperative ultrasound (iUS) provides real-time information that can be used to update neuronavigation and provide real-time information regarding the resection progress. We describe the intraoperative use of 3D iUS in relation to iMRI, and discuss the challenges and opportunities in its use in neurosurgical practice.

Methods

We performed a retrospective evaluation of patients who underwent image-guided brain tumor resection in which both 3D iUS and iMRI were used. The study was conducted between June 2020 and December 2020 when an extension of a commercially available navigation software was introduced in our practice enabling 3D iUS volumes to be reconstructed from tracked 2D iUS images. For each patient, three or more 3D iUS images were acquired during the procedure, and one iMRI was acquired towards the end. The iUS images included an extradural ultrasound sweep acquired before dural incision (iUS-1), a post-dural opening iUS (iUS-2), and a third iUS acquired immediately before the iMRI acquisition (iUS-3). iUS-1 and preoperative MRI were compared to evaluate the ability of iUS to visualize tumor boundaries and critical anatomic landmarks; iUS-3 and iMRI were compared to evaluate the ability of iUS for predicting residual tumor.

Results

Twenty-three patients were included in this study. Fifteen patients had tumors located in eloquent or near eloquent brain regions, the majority of patients had low grade gliomas (11), gross total resection was achieved in 12 patients, postoperative temporary deficits were observed in five patients. In twenty-two iUS was able to define tumor location, tumor margins, and was able to indicate relevant landmarks for orientation and guidance. In sixteen cases, white matter fiber tracts computed from preoperative dMRI were overlaid on the iUS images. In nineteen patients, the EOR (GTR or STR) was predicted by iUS and confirmed by iMRI. The remaining four patients where iUS was not able to evaluate the presence or absence of residual tumor were recurrent cases with a previous surgical cavity that hindered good contact between the US probe and the brain surface.

Conclusion

This recent experience at our institution illustrates the practical benefits, challenges, and opportunities of 3D iUS in relation to iMRI.
Analysis of Gastric Cancer Transcriptome Allows the Identification of Histotype Specific Molecular Signatures With Prognostic Potential
Authors: Carino Adriana , Graziosi Luigina , Marchianò Silvia , Biagioli Michele , Marino Elisabetta , Sepe Valentina , Zampella Angela , Distrutti Eleonora , Donini Annibale , Fiorucci Stefano
Published: May 2021

Gastric cancer is the fifth most common malignancy but the third leading cause of cancer-associated mortality worldwide. Therapy for gastric cancer remain largely suboptimal making the identification of novel therapeutic targets an urgent medical need. In the present study we have carried out a high-throughput sequencing of transcriptome expression in patients with gastric cancers. Twenty-four patients, among a series of 53, who underwent an attempt of curative surgery for gastric cancers in a single center, were enrolled. Patients were sub-grouped according to their histopathology into diffuse and intestinal types, and the transcriptome of the two subgroups assessed by RNAseq analysis and compared to the normal gastric mucosa. The results of this investigation demonstrated that the two histopathology phenotypes express two different patterns of gene expression. A total of 2,064 transcripts were differentially expressed between neoplastic and non-neoplastic tissues: 772 were specific for the intestinal type and 407 for the diffuse type. Only 885 transcripts were simultaneously differentially expressed by both tumors. The per pathway analysis demonstrated an enrichment of extracellular matrix and immune dysfunction in the intestinal type including CXCR2, CXCR1, FPR2, CARD14, EFNA2, AQ9, TRIP13, KLK11 and GHRL. At the univariate analysis reduced levels AQP9 was found to be a negative predictor of 4 years survival. In the diffuse type low levels CXCR2 and high levels of CARD14 mRNA were negative predictors of 4 years survival. In summary, we have identified a group of genes differentially regulated in the intestinal and diffuse histotypes of gastric cancers with AQP9, CARD14 and CXCR2 impacting on patients’ prognosis, although CXCR2 is the only factor independently impacting overall survival.
Centhaquine Restores Renal Blood Flow and Protects Tissue Damage After Hemorrhagic Shock and Renal Ischemia
Authors: Ranjan Amaresh K. , Zhang Zhong , Briyal Seema , Gulati Anil
Published: May 2021

Background: Centhaquine (CQ) (Lyfaquin®) is in late stage clinical development as a safe and effective first-in-class resuscitative agent for hemorrhagic shock patients (NCT02408731, NCT04056065, and NCT04045327). Acute kidney injury (AKI) is known to be associated with hemorrhagic shock. Hence, effect of CQ on protection of kidneys from damage due to hemorrhagic shock was investigated.

Methods: To assess effect of CQ on AKI in shock, we created a rat model with hemorrhagic shock and AKI. Renal arteries were clamped and de-clamped to induce AKI like ischemia/reperfusion model and hemorrhage was carried out by withdrawing blood for 30 min. Rats were resuscitated with CQ (0.02 mg/kg) for 10 min. MAP, heart rate (HR), and renal blood flow (RBF) were monitored for 120 min.

Results: CQ produced a significant improvement in RBF compared to vehicle (p< 0.003) even though MAP and HR was similar in CQ and vehicle groups. Blood lactate level was lower (p = 0.0064) in CQ than vehicle at 120 min post-resuscitation. Histopathological analysis of tissues indicated greater renal damage in vehicle than CQ. Western blots showed higher HIF-1α (p = 0.0152) and lower NGAL (p = 0.01626) levels in CQ vs vehicle. Immunofluorescence in the kidney cortex and medulla showed significantly higher (p< 0.045) expression of HIF-1α and lower expression of Bax (p< 0.044) in CQ. Expression of PHD 3 (p< 0.0001) was higher, while the expression of Cytochrome C (p = 0.01429) was lower in the cortex of CQ than vehicle.

Conclusion: Results show CQ (Lyfaquin®) increased renal blood flow, augmented hypoxia response, decreased tissue damage and apoptosis following hemorrhagic shock induced AKI, and may be explored to prevent/treat AKI.

Translational Statement: Centhaquine (CQ) is safe for human use and currently in late stage clinical development as a first-in-class resuscitative agent to treat hemorrhagic shock. In the current study, we have explored a novel role of CQ in protection from hemorrhagic shock induced AKI, indicating its potential to treat/prevent AKI.
Withania somnifera (L.) Dunal: Opportunity for Clinical Repurposing in COVID-19 Management
Authors: Saggam Akash , Limgaokar Kirti , Borse Swapnil , Chavan-Gautam Preeti , Dixit Santosh , Tillu Girish , Patwardhan Bhushan
Published: May 2021

As the COVID-19 pandemic is progressing, the therapeutic gaps in conventional management have highlighted the need for the integration of traditional knowledge systems with modern medicine. Ayurvedic medicines, especially Ashwagandha (Withania somnifera (L.) Dunal, WS), may be beneficial in the management of COVID-19. WS is a widely prescribed Ayurvedic botanical known as an immunomodulatory, antiviral, anti-inflammatory, and adaptogenic agent. The chemical profile and pharmacological activities of WS have been extensively reported. Several clinical studies have reported its safety for use in humans. This review presents a research synthesis of in silico, in vitro, in vivo, and clinical studies on Withania somnifera (L.) Dunal (WS) and discusses its potential for prophylaxis and management of COVID-19. We have collated the data from studies on WS that focused on viral infections (HIV, HSV, H1N1 influenza, etc.) and noncommunicable diseases (hypertension, diabetes, cancer, etc.). The experimental literature indicates that WS has the potential for 1) maintaining immune homeostasis, 2) regulating inflammation, 3) suppressing pro-inflammatory cytokines, 4) organ protection (nervous system, heart, lung, liver, and kidney), and 5) anti-stress, antihypertensive, and antidiabetic activities. Using these trends, the review presents a triangulation of Ayurveda wisdom, pharmacological properties, and COVID-19 pathophysiology ranging from viral entry to end-stage acute respiratory distress syndrome (ARDS). The review proposes WS as a potential therapeutic adjuvant for various stages of COVID-19 management. WS may also have beneficial effects on comorbidities associated with the COVID-19. However, systematic studies are needed to realize the potential of WS for improving clinical outcome of patients with COVID-19.
Natural Products Modulating Angiotensin Converting Enzyme 2 (ACE2) as Potential COVID-19 Therapies
Authors: Abubakar Murtala Bello , Usman Dawoud , El-Saber Batiha Gaber , Cruz-Martins Natália , Malami Ibrahim , Ibrahim Kasimu Ghandi , Abubakar Bilyaminu , Bello Muhammad Bashir , Muhammad Aliyu , Gan Siew Hua , Dabai Aliyu Ibrahim , Alblihed M , Ghosh Arabinda , Badr Reem H. , Thangadurai Devarajan , Imam Mustapha Umar
Published: May 2021

The 2019 coronavirus disease (COVID-19) is a potentially fatal multisystemic infection caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Currently, viable therapeutic options that are cost effective, safe and readily available are desired, but lacking. Nevertheless, the pandemic is noticeably of lesser burden in African and Asian regions, where the use of traditional herbs predominates, with such relationship warranting a closer look at ethnomedicine. From a molecular viewpoint, the interaction of SARS-CoV-2 with angiotensin converting enzyme 2 (ACE2) is the crucial first phase of COVID-19 pathogenesis. Here, we review plants with medicinal properties which may be implicated in mitigation of viral invasion either via direct or indirect modulation of ACE2 activity to ameliorate COVID-19. Selected ethnomedicinal plants containing bioactive compounds which may prevent and mitigate the fusion and entry of the SARS-CoV-2 by modulating ACE2-associated up and downstream events are highlighted. Through further experimentation, these plants could be supported for ethnobotanical use and the phytomedicinal ligands could be potentially developed into single or combined preventive therapeutics for COVID-19. This will benefit researchers actively looking for solutions from plant bioresources and help lessen the burden of COVID-19 across the globe.
Flipping Interferometric Module for Simultaneous Dual-Wavelength Unwrapping of Quantitative Phase Maps of Biological Cells
Authors: Karako Lidor , Guo Rongli , Barnea Itay , Shaked Natan T.
Published: May 2021

We present an imaging platform for stain-free quantitative imaging of biological cells using a simultaneous dual-wavelength holographic module. We use this module to experimentally solve the problem of 2π phase ambiguities that occurs in spatial locations where the optical thickness of the sample is larger than the wavelength. Thus, the process does not require using digital phase unwrapping that is computational heavy and impairs real-time processing. The proposed method is not limited to sequential acquisition of two quantitative phase maps in different times, but rather allows optical multiplexing of two off-axis holograms on the camera at once, enabling acquisition of fast dynamic processes. The module is simple and portable, making it attractive for clinical use. We demonstrate using the module for quantitative phase imaging of cancer and sperm cells.
Symptomatic Premature Ventricular Contractions in Vasovagal Syncope Patients: Autonomic Modulation and Catheter Ablation
Authors: Zheng Lihui , Sun Wei , Qiao Yu , Hou Bingbo , Guo Jinrui , Killu Ammar , Yao Yan
Published: May 2021

Introduction

There has been limited reports about the comorbid premature ventricular contractions (PVCs) and vasovagal syncope (VVS). Deceleration capacity (DC) was demonstrated to be a quantitative evaluation to assess the cardiac vagal activity. This study sought to report the impact of autonomic modulation on symptomatic PVCs in VVS patients.

Methods and Results

Twenty-six VVS patients with symptomatic idiopathic PVCs were consecutively enrolled. Identification and catheter ablation of left atrial ganglionated plexi (GP) and PVCs were performed in 26 and 20 patients, respectively. Holter 24 h-electrocardiograms were performed before and after the procedure to evaluate DC and PVCs occurrence. Eighteen patients were subtyped as DC-dependent PVCs (D-PVCs) and eight as DC-independent PVCs groups (I-PVCs). In D-PVCs group, circadian rhythm of hourly PVCs was positively correlated with hourly DC (P < 0.05) while there was no correlation in I-PVCs group (P > 0.05). Fifty-three GPs with positive vagal response were successfully elicited (2.0 ± 0.8 per patient). PVCs failed to occur spontaneously nor to be induced in six patients. In the remaining 20 patients, PVCs foci identified were all located in the ventricular outflow tract region. Post-ablation DC decreased significantly from baseline (P < 0.05). During mean follow-up of 10.64 ± 6.84 months, syncope recurred in one patient and PVCs recurred in another. PVCs burden of the six patients in whom neither catheter ablation nor antiarrhythmic drugs were applied demonstrated a significant decrease during follow-up (P = 0.037).

Conclusion

Autonomic activities were involved in the occurrence of symptomatic idiopathic PVCs in some VVS patients. D-PVCs might be facilitated by increased vagal activities. Catheter ablation of GP and PVCs foci may be an effective, safe treatment in patients with concomitant VVS and idiopathic PVCs.
Inspection of Histological 3D Reconstructions in Virtual Reality
Authors: Lobachev Oleg , Berthold Moritz , Pfeffer Henriette , Guthe Michael , Steiniger Birte S.
Published: May 2021

3D reconstruction is a challenging current topic in medical research. We perform 3D reconstructions from serial sections stained by immunohistological methods. This paper presents an immersive visualization solution to quality control (QC), inspect, and analyze such reconstructions. QC is essential to establish correct digital processing methodologies. Visual analytics, such as annotation placement, mesh painting, and classification utility, facilitates medical research insights. We propose a visualization in virtual reality (VR) for these purposes. In this manner, we advance the microanatomical research of human bone marrow and spleen. Both 3D reconstructions and original data are available in VR. Data inspection is streamlined by subtle implementation details and general immersion in VR.
Hypoxia Signaling in Cancer: From Basics to Clinical Practice
Authors: Sebestyén Anna , Kopper László , Dankó Titanilla , Tímár József
Published: May 2021

Cancer hypoxia, recognized as one of the most important hallmarks of cancer, affects gene expression, metabolism and ultimately tumor biology-related processes. Major causes of cancer hypoxia are deficient or inappropriate vascularization and systemic hypoxia of the patient (frequently induced by anemia), leading to a unique form of genetic reprogramming by hypoxia induced transcription factors (HIF). However, constitutive activation of oncogene-driven signaling pathways may also activate hypoxia signaling independently of oxygen supply. The consequences of HIF activation in tumors are the angiogenic phenotype, a novel metabolic profile and the immunosuppressive microenvironment. Cancer hypoxia and the induced adaptation mechanisms are two of the major causes of therapy resistance. Accordingly, it seems inevitable to combine various therapeutic modalities of cancer patients by existing anti-hypoxic agents such as anti-angiogenics, anti-anemia therapies or specific signaling pathway inhibitors. It is evident that there is an unmet need in cancer patients to develop targeted therapies of hypoxia to improve efficacies of various anti-cancer therapeutic modalities. The case has been opened recently due to the approval of the first-in-class HIF2α inhibitor.
As prioridades de quem produz: Entretenimento e violência nas fanpages dos jornais regionais
Authors: Massuchin Michele Goulart , Sousa Suzete Gaia de
Published: May 2021

A migração dos veículos para as redes sociais mostra a centralidade que o espaço tem adquirido nas redações, especialmente como forma de distribuir conteúdo e, principalmente, atrair leitores, a partir da política dos cliques. Assim, a necessidade de atualização contínua, associada ao interesse dos leitores por assuntos leves e/ou curiosos e a busca por acessos aos portais podem fazer com que os veículos passem a priorizar determinados conteúdos que, apesar da pouca contribuição ao debate público, cumprem sua função de gerar cliques. A partir desse pressuposto, o artigo traz uma análise sobre como veículos regionais impressos têm usado o Facebook. O estudo é feito com base em 2.825 postagens realizadas durante duas semanas de coleta de dados, sendo que foi usada a análise de conteúdo quantitativa como técnica de pesquisa. O objetivo do artigo, de modo específico, é verificar os temas das postagens realizadas, observando similaridades e diferenças entre as seguintes fanpages: A Tarde, Correio Braziliense, Diário Online, Gazeta do Povo e O Globo. Dentre os principais resultados, cita-se a priorização dada aos temas de entretenimento, porém percebeu-se também a veiculação de assuntos relacionados à violência, que se caracterizam pela proximidade e impacto das notícias.
Evaluation of Biological Activity of Different Wavelengths of Low-Level Laser Therapy on the Cancer Prostate Cell Line Compared With Cisplatin
Authors: Zafari Jaber , Abbasinia Hossein , Gharehyazi Hediyeh , Javani Jouni Fatemeh , Jamali Saeed , Razzaghi Mohammadreza
Published: May 2021

Introduction: Cancer is one of the most important problems in the world. Low-level laser therapy (LLLT) has been emerged as a new approach, having both stimulation and inhibition effects on cellular function. The goal of this study was to analyze and compare the different concentrations of cisplatin and wavelengths of laser therapy on the LnCap cell lines. Methods: LnCap cells were cultured and treated with different concentrations of cisplatin (0.1, 0.4, 0.8, 1.2 and 2 µg/mL for 24 hours) and wavelengths of laser therapy (610, 630 and 810 nm) (0.45 J/cm2 ) separately. The viability of cells was examined by MTT assay and IC50 was also calculated. Furthermore, a combination of cisplatin IC50 (24 hours) and different wavelengths of the laser was examined. Results: The results of this study showed that 2 µg/mL of cisplatin has the most significant reduction effect on the cell viability of the LnCap cell line. Cisplatin decreased the viability of cells in a dose-dependent manner. Moreover, IC50 of cisplatin was 1.24 µg/mL. On the other hand, LLLT with wavelengths of 610, 630 and 810 nm did not show notable biological effects on cell viability. Conclusion: As known, cisplatin has the capability to reduce the viability of LnCap cell lines. However, LLLT cannot be a remarkable option for the treatment of prostate cancer. Therefore, although laser therapy showed praiseful therapeutic activity against some cancer cell lines, in this study the results indicated that defined laser wavelengths had no inhibitory effects against the prostate cancer cell line.
A study on evaluation of site selection in sanitary landfill with regard to urban growth
Authors: Yazıcı Karabulut Benan , Derin Perihan , Yeşilnacar Mehmet İrfan , Çullu Mehmet Alı
Published: May 2021

Sanitary landfill is a widely used waste disposal method worldwide due to its safe and economic. The most important issue in this storage method is the process of selecting the landfill. This process is one of the critical issues in the urban planning process due to its enormous impact on the region's economy, ecology, and environmental health. At the same time, it is also a great importance for public health. Urban growth is a phenomenon that is difficult to stop or limit in line with economic dynamics and demographic changes. For this reason, site selection in solid waste sanitary landfill is a great importance in terms of ensuring a sustainable urban future. The site selection in sanitary landfill is made conventionally taking into account environmental, social and economic criteria. In this study, the waste disposal facility, which was built according to the mentioned criteria and still in operation, was evaluated in the context of urban growth. In this context, Landsat TM 1989 satellite image for the determination of urban boundaries of the central settlement area of Sanliurfa before the irrigation of the GAP project, and Sentinel-2 satellite image enrichment to determine the urban development boundaries after irrigation was mapped by Screen digitizing. Its spatial evaluation and mapping were performed utilizing ArcGIS software.
Havza ve Arazi Karakteristiklerinin Coğrafi Bilgi Sitemleri (CBS) Yardımıyla Değerlendirilmesi: Pazar Hemşin Deresi Havzası Örneği
Authors: ÖZÇELİK Ali Erdem , YUKSEK Turan , YÜKSEK Filiz , VEREP Bülent
Published: May 2021

Doğal kaynaklar sürekli etkileşim halinde olan ekosistemlerdir. Bu ekosistemlerin planlanması bütünleşik havza planlanma ilkelerine göre yapılmalıdır. Ancak Rize il ölçeğindeki doğal kaynak planlama ve altyapı çalışmalarında bu hususun layıkıyla dikkate alındığı pek söylenemez. Bu çalışmanın amacı Pazar Hemşin havzası bazı havza karakteristikleri ile arazilerin yükselti kademeleri, eğim, bakı ve jeolojik yapıya göre dağılımlarının Coğrafi Bilgi Sistemi (CBS) yardımıyla ortaya konulmasıdır. Araştırma sonucuna göre Pazar Hemşin havzasının drenaj alanı 21216 hektar ve ortalama eğimi % 30.97’dir. Yükselti kademelerine göre en geniş arazi varlığı 4153.35 hektar (%19.58) ile 901-1200 m yükseltiler arasında ve en az arazi varlığı 633.26 hektar (%2.98) ile 2100-2400 m yükseltileri arasında olduğu belirlenmiştir. Eğim ve bakı faktörlerine göre arazilerin % 63.14’ü gölgeli bakılar üzerinde ve % 36.86’sı güneşli bakılar üzerindedir. Eğime göre en geniş ziraat alanı % 38.35 ile % 11-20 eğim gurubunda yer almaktadır. Orman arazilerinin % 30.44’ü asidik kayaçlar, % 69.43’ü nötr kayaçlar ve % 0.13 ile alüvyon alanlar üzerindedir. Kayaç türlerine göre en geniş orman varlığı % 30.33 ile granit kayaçlar üzerindedir. Yerleşim yerlerinin % 44.55’i asidik kayaçlar, % 54.37’si nötr kayaçlar ve % 1.08’i ile alüviyon alanlar üzerindedir. Mevcut yerleşim yerlerinin % 63.99’u gölgeli bakılar üzerinde, % 36.01’i güneşli bakılar üzerindedir. Havza genelinde yerleşim yeri kullanımlarında gölgeli bakılar baskın durumdadır. Yerleşim alanları ile eğim gurupları arasında R² = 0,831 ve y = -2,1523x2 + 9,6437x + 15,559 şeklinde polinomvari bir ilişki belirlenmiştir. Yerleşim yerlerinin seçimi, yol ve alt yapı çalışmaları ile tarım arazilerinin kullanılmasında yukarıda ortaya konulan havza özelliklerinin dikkate alınması hem sorunlarınların çözümlenmesi hemde sürdürülebilir havza yönetimi için faydalı olabilir.
Birds of a Feather Flock Together and Opposites Attract: The Nonlinear Relationship Between Personality and Friendship
Authors: Liu Haiyan , Zhang Zhiyong
Published: May 2021

Whether birds of a feather flock together or opposites attract is a classical research question in social and personality psychology. In most existing studies, correlation-based techniques are commonly used to study the similarity/dissimilarity among social entities. Social network data comprises two primary components: actors and the possible social relations between them. It, therefore, has observations on both the dyads with and without social relations. Because of the availability of the baseline group (dyads without social relations), it is possible to contrast the two groups of dyads using social network analysis techniques. This study aims to illustrate how to use social network analysis techniques to address psychological research questions. Specifically, we will investigate how the similarity or dissimilarity of actor's characteristics relates to the likelihood for them to build social relations. By analyzing a college friendship network, we found the quadratic relations between personality similarity and friendship. Both very similar and very dissimilar personalities boost friendship among college students.
Crisis en la identidad profesional docente en estudiantes de Licenciatura en Pedagogía Infantil. Estudio de caso en una universidad pública
Authors: González Giraldo Omaira Elizabeth , Castellanos Sánchez Maria Teresa , Bolaños Motta José Ignacio
Published: May 2021

La identidad profesional docente se configura en la relación entre los procesos educativos, la autobiografía formativa y las características de las culturas profesorales. Este artículo de investigación tiene por objetivo comprender la condición de crisis en la configuración de la identidad profesional docente de los estudiantes de Licenciatura en Pedagogía Infantil de la Universidad de los Llanos. Se desarrolló en el ámbito de la investigación cualitativa, desde el enfoque de la fenomenología hermenéutica, con elementos de la semántica estructural y del método de análisis estructural de contenido. La información se recabó en entrevistas biográficas narrativas individuales y grupales. Se develaron dos categorías semánticas: la relación entre los trayectos formativos del futuro pedagogo infantil y la crisis en la identidad profesional, y las complejas interacciones entre la crisis en la identidad profesional docente y la crisis de la categoría infancias. Se concluye que la configuración de la identidad profesional docente es continua e inicia en los primeros años de formación escolar, y continúa hasta la vida laboral. Esta identidad en los futuros pedagogos infantiles está en crisis por la desvalorización a su quehacer educativo, y se profundiza esta situación por la crisis de su objeto de formación: la educación de las infancias.
Problemas matemáticos en el caso de un currículo
Authors: Chavarría-Arroyo Gilberto , Albanese Verónica
Published: May 2021

El objetivo de este estudio es analizar el contexto y la contextualización de problemas presentes en el caso del currículo de Costa Rica desarrollado en la reforma de 2012. La metodología es mixta, con un análisis cualitativo de contenido y un posterior recuento cuantitativo. El sistema de categorías se elabora a partir de la revisión bibliográfica, considerando tipos de contexto y tipos de contextualización. El 59,5% del total de 141 problemas tienen contexto científico/matemático, muy pocos de los cuales se ajustan auna contextualización activa. Asimismo, los contextos rurales e indígenas están ausentes. De ahí que concluyamos sobre la existencia de desajustes entre los fundamentos teóricos del caso de currículo de matemáticas y los ejemplos que se plantean. Acabamos proponiendo la discusión de nuestras categorías como indicadores para construir problemas matemáticos con contextualización activa y significativa.
Prácticas matemáticas democráticas
Authors: Vanegas Yuly , Giménez Joaquín
Published: May 2021

En este artículo proponemos caracterizar las prácticas matemáticas democráticas promovidas en una clase de matemáticas con estudiantes de 12 y 13 años centrada en la enseñanza y el aprendizaje de la medida de longitud. Se muestra que la promoción de estas prácticas posibilita negociar exitosamente significados matemáticos. Se realiza un análisis donde junto con la identificación de prácticas matemáticas democráticas se observan normas, para describir e interpretar los procesos interactivos que dan forma a la participación de profesor y estudiantes en las sesiones de clase. Los resultados indican el dominio de prácticas relacionadas con la articulación y resolución de conflictos. También se constata un determinado tipo de normas en relación con cada tipo de práctica matemática democrática
PENGARUH KONSENTRASI LARUTAN DAUN JAMBU BIJI (Psidium guajava) DAN LAMA PERENDAMAN TERHADAP KUALITAS TELUR AYAM RAS
Authors: Ernawati Tri , Karisoh Linda Ch. M. , Hadju Rahmawaty , Siswosubroto Surtijono E.
Published: May 2021

THE EFFECT OF GUAVA LEAF SOLUTION CONCENTRATION AND SOAKING DURATION ON THE QUALITY OF CHICKEN EGGS.      This study aims to determine the effect of guava leaf solution concentration and soaking time on the quality of chicken eggs. This research was conducted from November to December 2018, at the Laboratory of Animal Product Technology, Faculty of Animal Husbandry, Sam Ratulangi University, Manado. The method used is Completely Randomized Design (CRD) with a factorial pattern consisting of 2 factors. Factor A was the concentration of solution of guava leaves and factor B is the length of immersion with 4 replications. The treatments used are: Factor A concentration of solution of guava leaves A1 = 3%, A2 = 6%, A3 = 9%, A4 = 12%. Factor B was duration of immersion B1 = 6 hours, B2 = 12 hours, B3 = 18 hours, B4 = 24 hours. The variables analyzed were a decrease in egg weight, egg white index and egg yolk index. Data obtained were analyzed by variety. If there are significant differences between treatments, it will be continued with Duncan Test. The results of the variance analysis showed that the interaction had a significant effect (P <0.05) on the decrease in egg weight and did not significantly influence (P> 0.05) on the egg white index and egg yolk index. Duncan's Test results for decreasing egg weight showed the concentration of guava leaf solution 3% and soaking time 6 hours  gave good results for the quality of chicken eggs. It was concluded that the concentration of 3% and the soaking time of 6 hours gives good results on decreasing egg weight. As for the egg white index and egg yolk index showed good results with concentration of 12% and 24-hour immersion time. Keywords: Guava leaf, Egg weight, Egg white index, Egg yolk index.
ANALISIS PERSEPSI PETANI PETERNAK TERHADAP PERAN PENYULUHAN DALAM PENGEMBANGAN AGRIBISNIS PETERNAKAN BABI DI DESA GIWAN KECAMATAN TIOM KABUPATEN LANNY JAYA
Authors: Yoman Elinde , Massie M T , Osak R E.M.F , Pandey J
Published: May 2021

ANALYSIS OF FARMERS' PERCEPTIONS TOWARD THE ROLE OF COUNSELING IN THE DEVELOPMENT OF PIG FARMING ON AGRIBUSINESS IN GIWAN VILLAGE, TIOM DISTRICT, LANNY JAYA REGENCY. The objective of this study was to determine farmer’s perceptons toward the role of agricultural extension agents in the development of pig livestock agribusiness for breeder’s in Giwan Village, Tiom District, Lanny Jaya Regency. This study used a survey method. Sample of group breeder wasdetermined by purposive sampling and sample of breeders was selected by simple random sampling method. The results of the study showed that: (1) Most pig farmers in Giwan village had good or high perceptions of extension workers in their roles as educators (80%), still have moderate as consultants (75%), as motivators (75%), and as organizers (80%) of farmers in providing counseling in Giwan village. The conclusion of this research was farmers in Giwan village have good perceptions of extension workers in their roles as educators, motivators, and as organizers of farmers in managing pigs' business.Keywords:  Agribusiness, Pig Farm, Extension, Giwan.
KARAKTERISTIK KONSUMEN DALAM PEMBELIAN DAGING SAPI DI KOTA MANADO (STUDI KASUS DI TRANSMART CARREFOUR STAR SQUARE MANADO)
Authors: Mongi Anastasia I , Wantasen E , Salendu A H.S , Manese M
Published: May 2021

CONSUMERS CHARACTERISTICS IN  PURCHASING BEEF IN MANADO CITY (Case Study On Transmart Carrefour Star Square Manado).Beef is one of the products farm source of protein easily found in the modern market and traditional markets. Consumer behavior is the study of decision making.Consumer characteristics are part of consumer behavior so companies that sell products need to recognize consumer characteristics and decision models made by consumers and innovate on beef attributes so that they can attract consumers to buy. Respondents in this stady  were 100 determined by the probability of sampling non  next using descriptive analysis through the questionnaire to know the types of buyers. The results showed that the types of buyers of beef in transmart Carrefour star square manado dominated by consumers women are mostly housewives with average ages of more than 40 years, monthly income on 3 million with the education level medium to collage.Keywords : Beef, consumer characteristics, beef attribute
Prospective Sub-Centers for the Development of the St. Petersburg Metropolitan Area: Trends and Opportunities for Spatial Transformation
Authors: Sviridenko M. V.
Published: May 2021

Aim. The presented study aims to analyze the opportunities and formulate directions for the development of prospective centers within the St. Petersburg metropolitan area in the context of implementation of the polycentric development model.

Tasks. The authors substantiate the need for a polycentric model for the development of the St. Petersburg metropolitan area; identify the features and directions of development of prospective sub-centers within the St. Petersburg metropolitan area at the current stage; formulate the limitations and directions of development of one of the agglomeration’s prospective subcenters — the Tosnensky municipal settlement.

Methods. This study uses general scientific methods of cognition, such as generalization, analysis, comparison, deduction and induction, methods of analytical assessment of statistics in the field of socio-economic development of territories, and analysis of fundamental scientific works of the Institute of Problems of Regional Economy of the RAS.

Results. To form a polycentric model of the St. Petersburg metropolitan area, the authors propose developing its prospective sub-centers. The study mainly focuses on the Tosnensky municipal settlement, which represents the major directions of socio-economic development of this sub-center within the St. Petersburg metropolitan area in accordance with the chosen vector of territorial socio-economic development.

Conclusions. Advanced foreign practices convincingly prove that the application of the polycentric model and the formation of prospective sub-centers for the development of metropolitan areas along with the heart of the agglomeration — a metropolis — are extremely relevant. From a strategic perspective, the examined sub-center can become a self-sufficient pole of the agglomeration’s economic growth. Examination of spatial aspects and formation of methodological and conceptual foundations for the development of agglomerations is a major fundamental research endeavor for Russian and foreign science.
A Review: Artificial Intelligent Approach for Enhancing Adaptability in an Adaptive
E-Learning Environment
Authors: Perera M.P.L.
Published: May 2021

Adaptive e-learning the aim is to fill the gap between
the pupil and the educator by discussing the needs and skills of
individual learners. Artificial intelligence strategies that have the
potential to simulate human decision-making processes are
important around adaptive e-Learning. This paper explores the
Artificial techniques; Fuzzy Logic, Neural Networks, Bayesian
Networks and Genetic Algorithms, highlighting their
contributions to the notion of the adaptability in the sense of
Adaptive E-learning. The implementation of Artificial Neural
Networks to resolve problems in the current Adaptive e-learning
frameworks have been established.
Analysis on Prediction of Customer Purchasing Decisions using Machine Learning
Authors: Raj Nehal , Singh Rajneesh Kumar , Srivastava Satyajee
Published: May 2021

In our day-to-day life, everyone settles on choices on
whether to purchase an item or not. In a couple of cases, the
choice depends on cost however on numerous occasions the
buying choice is more intricate, still, numerous other reasons
may be cogitated prior to the last decision is take. Within
large-scale industries, understanding existing consumer’s
purchasing behavior towards the product is more important to
drive a business to the next level. In the context to expand the
business on a large scale understanding, the customer interest is
more important. To understand the behavior of customers and
their interest in the products we need some new technologies and
a large amount of data. In this paper we present a progression of
examinations, investigate and analyze the exhibitions of various
ML strategies, and talk about the meaning of the discoveries with
regards to public arrangement and purchaser buying choice.
Utilizing an enormous certifiable informational collection
(which will be unveiled after the distribution of this work), we
present a progression of examinations, dissect and look at the
exhibitions of various ML procedures, and talk about the
meaning of the discoveries with regards to public strategy and
consumer buying Decision
Energy Monitoring Platform: AHigh-Performance Smart Meter Data Analytics Engine
Authors: Venkatesan Akshay , Sehgal Deepanshu , Sharma Sushant
Published: May 2021

4th Industrial revolution or Industry 4.0 is a concept
of factories in which machines are augmented with wireless
connectivity and sensors, connected to a system that can visualize
the entire production line and make decisions on its own. To
remain competitive, Industries or factories are one of the major
factors leading to the consumption of energy. However, these
industries are facing two obstacles. The first one is the low
availability of energy and the other is increased cost of the current
available energy. Different alternatives like Generators and
Inverters have their limitations when it comes to cost and supply.
The industries need to optimize the usage to stay price in check. It
has become a necessity for the industries reduce energy
consumption for a comparable level of activity to observe it. The
platform is the answer to these problems. It is a solution that puts
the client/user in control of their energy consumption by enabling
live monitoring of the energy smart grid data via a dedicated
online platform.
Experimental Analysis of Hybrid Energy Operated Refrigerator Coupled In EV
Authors: Kumar Surender , Bharj* R.S.
Published: May 2021

This paper is focused on the performance of a
solar-assisted DC refrigerator installed on the backside of the
electric vehicle (EV). The experiments are performed by varying
load conditions inside the refrigerator. The experimental setup
consists of four solar PV panels, a charge controller, battery bank,
voltage converter, DC refrigerator, and an electric vehicle. The
temperature inside the refrigerator cabin was controlled with the
thermostat position adjustment. The solar PV panels of the vehicle
was generating 2.5-4 kWh energy on the average sunny day. The
refrigerator's inside temperature was decreased with a faster rate
at the third thermostat position and consuming higher energy at
the seventh thermostat position among all load conditions. The
fourth and fifth thermostat positions were better at maintaining
the lower desired temperature inside the refrigerator cabin by
consuming the minimum energy. The COP of the refrigerator was
decreasing with the increasing compressor speed. The battery
bank was able to run the refrigerator 240 hr, 96 hr, 72 hr for the
no-load, 15 L load, and 25 L load conditions at the higher
thermostat position. The vehicle was travelling 68.3 km, 65.3.6
km, 63.4 km distance in no-load, 100 kg, and 200 kg load
conditions respectively by consuming 3010 Wh, 3230 Wh, and
3450 Wh energy. The travelling charge of this vehicle was 1-1.5
INR per kilometer
Cost Benefit Analysis for Electrical Loading System for Transformers of a Barangay
Authors: Manabat Carmela Mady B. , Alejo Marielle C. , Cruz. Loraine V. Dela , Apan Joseph M. , Jr, Renato D. Erasquin
Published: May 2021

The study assessed the cost and benefit of electrical
loading management of transformers. There is a serious
occurrence of over and under loaded transformer which deeply
affects the power quality or system loss and reliability of the
distribution lines. Initially, the percent loading of the 27
transformers of Feeder 21 were identified using Microsoft Excel
2016. Then, the identified transformers were classified into three
categories; overload (greater than 70%), under loaded (less than
40%) and normal loaded (40-70%). Through this process, three
(3) solutions were identified: Solution I - change the transformer
rating, Solution II – merge and transfer transformer loadsand
Solution III - combine solution I and II. The three-solution used
to identify the new percent loading to meet the normal percent
loading (40-69%). Subsequently, the reduced Core and Copper
Losses, Annual Energy Save, Savings and Benefit/Cost Ratio were
computed and analyzed to determine the impact of
loadingmanagement. The results show that there was an
accumulated savings of Php 332,060.08 for Solution I, Php
92,043.09 for Solution II and Php 252,045.78 for Solution III. In
the case of Benefit/Cost ratio it should be greater than 1 (>1) for a
project to be economically feasible and justifiable; Solution I was
1.22, Solution II was 687.3 and 1.93 for Solution III. Based on the
results of the study, SolutionIII was best among the three, for it
has met the criteria of all transformers were all in normal loaded
(40-70%) condition, and greater than 1 benefit/cost ratio.
Survey on Securing IoT Data using Homomorphic Encryption Scheme
Authors: Chaudhari Anita , Bansode Rajesh
Published: May 2021

In today’s world everyone is using cloud services.
Every user uploads his/her sensitive data on cloud in encrypted
form. If user wants to perform any type of computation on cloud
data, user has to share credentials with cloud administrator.
Which puts data privacy on risk. If user does not share his/her
credentials with cloud provider, user has to download all data and
only then decryption process and computation can be performed.
This research, focuses on ECC based homomorphic encryption
scheme is good by considering communication and computational
cost. Many ECC based schemes are presented to provide data
privacy. Analysis of different approaches has been done by
selecting different common parameters. Based on the analysis
minimum computation time is 0.25 Second required for ECC
based homomorphic encryption (HE).
Extracting Multiple Features for Dynamic Hand Gesture Recognition
Authors: S S Suni , K Gopakumar
Published: May 2021

In this work a framework based on histogram of
orientation of optical flow (HOOF) and local binary pattern from
three orthogonal planes (LBP_TOP) is proposed for recognizing
dynamic hand gestures. HOOF algorithm extracts local shape
and dynamic motion information of gestures from image
sequences and local descriptor LBP is extended to three
orthogonal planes to create an efficient motion descriptor. These
features are invariant to scale, translation, illumination and
direction of motion. The performance of the new framework is
tested in two different ways. The first one is by fusing the global
and local features as one descriptor and the other is using features
separately to train the multi class support vector machine.
Performance analysis shows that the proposed approach produces
better results for recognizing dynamic hand gestures when
compared with state of the art methods
Credit Card Fraud Detection using Machine Learning
Authors: Kumar Gautam , Kumar Shivanesh , Prakash A Arul
Published: May 2021

Now a days credit card plays a very important role in
the lives of the human being. It becomes an important part of the
businessman, global activities and many more. Even using credit
cards give us a most widely used of benefits when it used with the
responsibility and carefully, and very small credit and financial
harm is also caused by fraudulent activities or transactions. There
are a lot of techniques are given to encounter the scope in credit.
In spite of, whatever the methods are used they have the same goal
of clog the card fraud and each one has its own advantage,
drawback and the characteristics too. The deficiency and the good
of the credit card detection-methodologies are description and
dissimilarity. Moreover, a taxonomy of reference techniques are
classified in two fraud-detection perspective, as misuse
(supervised) and absurdity (unsupervised) is given. Again, a
taxonomy of methods is presented supported caliber to process the
categorical and numerical datasets. Other kind of datasets are
made in the literature then mentioned and sorted in real and club
into the group of the data and therefore the dominant and
customary attributes are removed for prosecute application.
Consequently, for the new researches, the issues for credit card
fraud-detection are described as per the recommendations.
Genetic Algorithm Applied to Planning IEEE 802.11g Networks
Authors: Barkouk Hamid , En-Naimi El Mokhtar , Mahboub Aziz
Published: May 2021

The problem of planning local wireless network IEEE 802.11g consists of automatically positioning and setting up wireless access points (APs) in order to provide access to the local network with the desired coverage and the required quality of service (QOS).In addition to the complexity of predicting the Quality of Service (QoS) of a network from the variables of the problem (positions, parameters and frequency of the APs), the planning of WLAN networks faces several difficulties. In particular, the location of APs and the allocation of frequencies. There is no single model to solve the problem of designing wireless local networks. Depending on the situations and the hypotheses studied, different criteria can be considered and expressed in terms of constraints to be observed or in terms of objectives to be optimized. The first distinction is to separate the financial criteria from the network quality criteria. The nature of these two criteria being fundamentally different. Then there are a variety of service quality criteria, but we can still group them into three main categories: coverage criteria, interference criteria and capacity criteria.. In this article, we will use an optimization method based on an algorithm of stochastic optimization, which is also based on the mechanisms of natural selection and of genetic. It is genetic algorithm. Our goal consist of minimizing the total interaction between the APs to perform the good choices when deploying a network 802.11g in a way that gives users signal-to-interference ratios (SIR) greater than the required threshold ß.
Regional Development Planning According to Economic and Natural Resources
Authors: Ragheb Amany , EL-Ayshmaw Rasha.A.
Published: May 2021

The sustainable urban development has emerged to
achieve a better life and prosperity for the individual in modern
society and in various areas of life.
The aim of this study represents new planning vision for the
western region of Delta to distribute it in new settlements out of
Delta. It is a broad vision of balanced development goals, along
western region of Delta, directing its physical expansion towards
new potential growth centers (Poles). We applied the theory of the
strategy of growth poles for economic and social growth potentials
are selected to intensify the elements of development, activating
the optimal use of its human and natural resources by working to
convert some of its cities into a group of growth poles and
mitigation centers.
The output result of SWOT analysis leads to three main major
growth poles, five sub growth poles and many linked growth poles
specialized developmental functions that become competitive
attractions for the existing urban areas according to human
distribution, efficient use of economic resources, natural
resources, and industrial technology. This leading activities and
adequate infrastructure to not to waste development resources and
investments available on large areas in the region.