bluuebunny/crossref_metadata_2025 huggingface dataset:
Dissolution of marriage during the spousal lifetime in ecclesiastical law
Authors:   HSE University, Silvestrova Elena V. ,   Ss. Cyril and Methodius Theological Institute of Postgraduate and Doctoral Studies
Published: June 2022

The article examines the concept of dissolution of ecclesiastical marriage according to modern legislation of the Russian Orthodox Church. The author studies the origins of this concept, while special attention is paid to secular law. The grounds of dissolution of ecclesiastical marriage are specifically analyzed. The article studies the historical prerequisites for the formation of the Russian Orthodox Church concept of divorce, which determines the grounds for the termination of ecclesiastical marriage during the life of the spouses. The author comes to the conclusion that the idea of ecclesiastical marriage dissolution is consistent in general with eastern orthodox canonical tradition. The influence of the Russian Orthodox Church’s own tradition is of particular importance for the modern concept. At the same time, there are gaps in the modern provisions of ecclesiastical legislation on marriage; e. g., the legislator does not pay sufficient attention to certain new public life phenomena. In addition, the author notes that current legislation of the Russian Orthodox Church does not introduce an obligation of the laity to dissolve an ecclesiastical marriage in connection with certain circumstances considered in Eastern Orthodox canon law as grounds for divorce. The principle of family law of the Russian Orthodox Church is the protection of marriage.
The Orthodox clergy of Crimea in the First World War and the Civil War in a new historical study
Authors:   Don State Technical University, Biryukova Yuliya A. , Olenich Tamara S. ,   Don State Technical University, Shakhbanova Nataliya A. ,   Don State Technical University
Published: June 2022

This review explores a new study on the history of the Crimean clergy during the First World War and the Civil War, up to the exodus of the white forces from the Crimea in November 1920. The authors of the monograph work at St Petersburg State University: Professor A. S. Puchenkov and Associate Professor V. V. Kalinovsky. The study examines such little-studied issues as the attitude of the clergy as a class and its individual representatives to the war, to politics, to reforms within the Church itself. During the war, the Crimean clergy took a peacemaking position, preventing German pogroms in the Tauride diocese. It should be noted that the revolutionary forces at various levels exercised increased control over the content of the sermons of the clergy, and the new government tried to influence the church authorities and the congresses of the clergy. The Church was perceived by society as a force closely connected with the monarchy. Criticism and hostility towards the Church began to worsen, resulting in open persecution after the October revolution. The authors of the review concluded that the authors managed to create a fundamental work, the absolute merit of which is the reconstruction of church life against the background of socio-political and military upheavals. The authors took a balanced position, without deviating into apologetics or criticism of the clergy. The work disposes to the comprehension of many controversial and complex topics.
Development of customized water quality index for medium- and long-term evaluation of urban river water quality
Authors: Lee J. H. , Lee J. Y. , Cha Y. S. , Cho S. J. , Kim T. H. , Cha Y. K. , Koo J. Y.
Published: June 2022

In this study, a customized WQI (Seoul water quality index, S-WQI) for urban rivers that can ultimately reflect their characteristics was developed by modifying and supplementing the existing Bascarόn WQI calculation method through linkage with statistical methods such as factor analysis. We used the water quality data generated monthly at 17 water quality monitoring networks (WQMNs) in Seoul for 18 years, from 2002 to 2019. Results of the research show that the monthly S-WQI showed an average 70 out of 100, ‘good (II)’ grades, whereas the average water quality grade according to the environmental standards was ‘slightly good (II),’ with an R2 value of 0.8298. The annual S-WQI was found to be 39 (bad) to 97 (very good), with an average of 72 (good). Through this study, S-WQI, a customized WQI for urban rivers, was judged to be a reasonable index that can represent the characteristics of urban river water quality. This is because it is easy to apply and is a calculation method that uses relatively fewer water quality items than the WQI calculated in the past, and it is highly likely to be linked to the currently implemented water quality grade system. In addition, to extend the application of WQI to various water quality survey points, based on the calculation methodology performed to derive the indices in this study, such as modified S-WQI (MS-WQI), by adding new water quality items and changing some items, it is also possible to develop an advanced customized WQI for urban rivers considering watershed characteristics and measurement items.
Fasting Plasma Glucose and Glycohemoglobin with Allergic Symptoms
and Specific Sensitization: Results from NHANES 2005-2006
Authors: Tao Ze-Zhang , Lu Gan , Deng Yu-Qin , Xi Yang , Li Song , Chen Shi-Ming , Kong Yong-Gang , Xu Yu , Li Fen
Published: June 2022

Objective:

The National Health and Nutrition Examination Survey (NHANES) data has
been used to study the relationship between fasting plasma glucose (FPG) and glycohemoglobin
(A1c) in patients with allergic symptoms and specific sensitization, respectively.

Methods:

A total of 1,687 participants and a variety of logistic regression models were selected
based on the 2005-2006 NHANES (n = 10,348) for our study to describe the relationship between
FPG and A1c in subjects with the sensitivity of allergic symptoms, specific sensitization and specific
sensitization of 19 allergens, respectively. On this basis, a variety of logistic regression models
were further established for hierarchical analysis to study the limiting conditions when FPG and
A1c were related to allergic symptoms.

Results:

We adjusted the confounding factors and found that the risk of specific sensitization increased
with the increase in FPG and A1c. Stratified analysis showed that the risk of allergic symptoms
increased with the increase in FPG and A1c when born elsewhere other than in the U.S. and
Mexico or underweight or overweight or with hypertension. Furthermore, we found that the risk of
egg sensitization increased with the increase in FPG and A1c, while the risk of rat sensitization decreased
with the increase in FPG.

Conclusion:

Under certain conditions, FPG and A1c were risk factors for allergic symptoms. FPG
and A1c were risk factors for specific sensitization, especially egg sensitization. These findings indicate
a possible link between diabetes and allergies.
miRNA-633 and KAI1 as Potential Biomarkers of Malignant Melanoma
with Gastric Cancer
Authors: Wang Zheng-Xiang , Zhang Guang-Jing , Yang Xiu-Fang , Feng Shi-Jun , Ji Shan-Shan , Qi Ya-Bin
Published: June 2022

Objective:

Malignant melanoma with gastric cancer is one of the most malignant
tumors. However, there have been no reports on the effects of KAI1 and miRNA-633 on the survival
and prognosis of patients with malignant melanoma with gastric cancer.

Methods:

Fifty patients with malignant melanoma and gastric cancer were collected from October
2017 to December 2019. The clinical parameters included clinical information, such as sex, age,
tumor size, and tumor staging. RT-qPCR was used to detect the expression of KAI1 and miRNA-
633. The role of KAI1 and miRNA-633 on the overall survival of melanoma was explored by the
Pearson chi-square test, Spearman-rho correlation test, Univariate and multivariate cox regression
analyses, and Kaplan–Meier method. Furthermore, the bioinformatic analysis was used to verify
the role of KAI1 and miRNA-633 on malignant melanoma with gastric cancer.

Results:

The expression of KAI1 and miRNA-633 was significantly related with the tumor size
and staging of tumor (p<0.05) based on the Pearson chi-square test. Spearman’s correlation coefficient
displayed that KAI1 was significantly correlated with the miRNA-633 (ρ=-0.439, p=0.001).
The result of multivariate cox proportional regression analysis showed that KAI1 (HR =0.109,
95% CI: 0.031-0.375, p< 0.001), and miRNA-633 (HR = 13.315, 95% CI: 3.844-46.119, p<0.001)
were significantly associated with overall survival.

Conclusion:

The low expression level of KAI1 and high expression of miRNA-633 are significantly
correlated with the poor overall survival prognosis of malignant melanoma with gastric cancer,
to provide a basis for KAI1 and miRNA-633 to become novel molecular targets for malignant melanoma
with gastric cancer.
Surface Engineered Dendrimers: A Potential Nanocarrier for the Effective Management of Glioblastoma Multiforme
Authors: Sahoo Rakesh Kumar , Gupta Tanisha , Batheja Sanya , Goyal Amit Kumar , Gupta Umesh
Published: June 2022

Gliomas are the most prevailing intracranial tumors, which account for approximately 36% of the primary brain tumors of glial cells. Glioblastoma multiforme (GBM) possesses a higher degree of malignancy among different gliomas. The blood-brain barrier (BBB) protects the brain against infections and toxic substances by preventing foreign molecules or unwanted cells from entering the brain parenchyma. Nano-carriers such as liposomes, nanoparticles, dendrimers, etc. boost the brain permeability of various anticancer drugs or other drugs. The favorable properties like small size, better solubility, and the modifiable surface of dendrimers have proven their broad applicability in the better management of GBM. However, in vitro and in vivo toxicities caused by dendrimers have been a significant concern. The presence of multiple functionalities on the surface of dendrimers enables the grafting of target ligand and/or therapeutic moieties. Surface engineering improves certain properties like targeting efficiency, pharmacokinetic profile, therapeutic effect, and toxicity reduction. This review will be focused on the role of different surface-modified dendrimers in the effective management of GBM.
In silico Design of Novel SAM Analogs as Potential Inhibitors Against
N2G966 16s rRNA Methyltransferase (RsmD)
Authors: Salaikumaran Muthu Raj , Prasad Burra Venkata Laxmi Siva
Published: June 2022

Introduction:

Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), has its natural
history tracing back to 70,000 years. Latent M.tb infection is the reservoir of the TB epidemic. M.tb is
becoming more prevalent and acquiring multidrug resistance among the first-line antibiotics.

Methods:

Methylation is one of the main mechanisms through which bacteria develop resistance, hence
targeting methyltransferases provides the opportunity to achieve two-birds-with-one-stone: a) antibiotic:
inhibiting the translation activity and b) anti-resistance: eliminating methylation as a mode of resistance.
Currently, no known drugs or lead molecules are targeting the methyltransferases, in general, and rRNA
Small Subunit Methyltransferase D (RsmD) family, in particular, in M.tb species.

Results and Discussion:

S-Adenosyl-L-methionine(SAM) is known as the universal donor of a methyl
group which is an indispensable cofactor for the proper functioning of SAM-dependent methyltransferases.
This in silico study attempts to design and develop novel SAM-analog inhibitors against RsmD, which
in turn affects the growth and survival of M.tb in TB patients. The SAM-analogs were designed, after careful
study and analysis of RsmD pharmacophore and SAM binding properties. The functional groups such as
amide, amine, acetamide, formamide, hydroxyl, fluorine, iodine, and bromine were used to design novel
analogs with the aim to improve the binding of analog with RsmD. The analogs that gave better docking
scores followed by favourable binding affinities and ADMET properties than native SAM were ranked.

Conclusion:

Among the library of SAM analogs, the top two analogs with IDs: SAM_172 and SAM_153
need testing and validation for their efficacy through in vitro and in vivo studies.
Multi-Targeted Molecular Docking and Drug-Likeness Evaluation of some
Nitrogen Heterocyclic Compounds Targeting Proteins Involved in the
Development of COVID-19
Authors: Ravichandran Veerasamy , Hui Lok Yong , Mun Chan Sook , Sing Lai Cong , Rajak Harish , Karunakaran Rohini
Published: June 2022

Background:

The severe acute respiratory syndrome coronavirus-2 is causing a disaster
through coronavirus disease-19 (COVID-19), affecting the world population with a high mortality
rate. Although numerous scientific efforts have been made, we do not have any specific drug for
COVID-19 treatment.

Objective:

Aim of the present study was to analyse the molecular interaction of nitrogen
heterocyclic based drugs (hydroxychloroquine, remdesivir and lomefloxacin) with various SARSCoV-
2 proteins (RdRp, PLPro, Mpro and spike proteins) using a molecular docking approach.

Methods:

We have performed docking study using PyRx software, and Discovery Studio Visualizer
was used to visualise the molecular interactions. The designed nitrogen heterocyclic analogues were
checked for Lipinski’s rule of five, Veber's Law and Adsorption, Distribution, Metabolism, and
Excretion (ADME) threshold. After obtaining the docking results of existing nitrogen heterocyclic
drugs, we modified the selected drugs to get molecules with better affinity against SARS-CoV-2.

Results:

Hydroxychloroquine bound to RdRp, spike protein, PLPro and Mpro at -5.2, -5.1, -6.7 and
-6.0 kcal/mol, while remdesivir bound to RdRp, spike protein, PLPro, and Mpro at -6.1, -6.9, -6.4
and -6.9 kcal/mol, respectively. Lomefloxacin bound to RdRp, spike protein, PLPro and Pro at -6.4,
-6.6, -7.2 and -6.9 kcal/mol. ADME studies of all these compounds indicated lipophilicity and high
gastro intestine absorbability. The modified drug structures possess better binding efficacy towards
at least one target than their parent compounds.

Conclusion:

The outcome reveals that the designed nitrogen heterocyclics could contribute to developing
the potent inhibitory drug SARS-CoV-2 with strong multi-targeted inhibition ability and
reactivity
Recent Progress on Catalyst Supports for Propane Dehydrogenation
Authors: Wang Guangjian , Yin Chaoqun , Feng Fushan , Zhang Qinqin , Fu Haitao , Bing Liancheng , Wang Fang , Han Dezhi
Published: June 2022

Background:

Propane dehydrogenation (PDH) is the most potential propylene production technology, which can make up the large gap in downstream products of propylene. The catalyst supports lay the foundation for the catalytic activity and stability of the prepared catalysts in PDH reactions. Therefore, we focus on the discussion of single oxides, composite oxides, zeolites, and carbon materials as supports to demonstrate the improvement of the catalytic performance of the PDH catalysts.

Methods:

Recent studies on catalyst supports are reviewed, including the preparation, characterization, and PDH performance.

Results:

The supports with different morphologies and crystal structures have been reported for PDH. The enhanced strong interaction between the support and metal components is responsible for the superior PDH performance.

Conclusions:

The PDH catalysts mainly depend on the development of the support with specific physicochemical properties for the corresponding PDH processes. Therefore, it is crucial to develop the optimal supports to improve the PDH performance in the area of nanoscience materials.
Regenerative Medicine-Based Treatment of Stress Urinary Incontinence
with Mesenchymal Stem Cells: A Systematic Review and Meta-analysis
Authors: Mariotti Gianna , Salciccia Stefano , Viscuso Pietro , Bevilacqua Giulio , Casale Paolo , Frisenda Marco , Di Pierro Giovanni Battista , Cattarino Susanna , Gentilucci Alessandro , Rosati Davide , Sciarra Beatrice , Sciarra Alessandro
Published: June 2022

Objectives:

The aim of this systematic review and meta-analysis is to analyze clinical trials on the use of autologous stem cell [SC] injection for the treatment of stress urinary incontinence [SUI] in humans.

Methods:

We analyzed the effect in terms of UI improvement and continence recovery after treatment. A literature search was performed following the PRISMA guidelines. Entry into the analysis was restricted to data collected from clinical prospective trials on humans, including female and male patients with SUI. We performed a cumulative meta-analysis to explore the trend in the effect size across different groups at follow-up. Available data were compared in terms of Event Rate [ER] for the percentage of pad-free patients.

Results:

12 trials were enclosed in the analysis. Sample size of patients with SUI ranged from 5 to 123 cases, mainly female cases. Autologous muscle-derived [MDSC] were used in 9 and adipocyte-derived SC [ADSC] in 3 trials. Considering a random effect model, ER of continence recovery was 0.41 [95%CI 0.29 - 0.54], with similar results between the ADSC [ER, 0.40;95%CI 0.12 – 0.69] and the MDSC group [ER 0.41; 95%CI 0.27-0.55] [I2 84.69%; Q 104.69 - p<0.01] [Test of group differences p=0.96]

Conclusions:

Autologous MDSC or ADSC injection to treat SUI demonstrated to be a safe procedure and a 41% mean rate of continence recovery is described. A higher effort should be produced to design better clinical trials, objectively evaluating either modifications inside the urethral sphincter or long-term functional results in terms of pad test and UI questionnaires.
WITHDRAWN: Moderna’s COVID 19 Patent Under the Magnifying Glass
Authors: Storz Ulrich
Published: June 2022

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore,
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of their article is transferred to the publishers if and when the article is accepted for publication.
Correlation of Pericoronal Radiolucency Around Impacted Mandibular Third Molars Using CBCT with Histopathological Diagnosis: A Prospective Study
Authors: Ahmed Junaid , Nath Mandovi , Sujir Nanditha , Ongole Ravikiran , Shenoy Nandita
Published: June 2022

Purpose:

This study aimed to correlate the pericoronal width surrounding impacted mandibular third molars with their histopathological findings.

Materials and Methods:

The present study included patients who were advised for extraction of impacted mandibular third molars with the pericoronal radiolucency radiographically. The CBCT scans were compared with histopathologic findings of the follicles.

Results:

Out of 70 patients evaluated histopathologically, 24 patients showed mild inflammatory changes, whereas 34 patients revealed cystic changes suggestive of a dentigerous cyst, followed by 12 patients showing evidence of calcifications in the pericoronal follicles. The dentigerous cyst was more likely to occur if the bucco-lingual width of the pericoronal radiolucency was 14.00-16.00mm, and calcifications were found to be most likely present if the buccolingual width was 12.00-14.00mm, both of which were statistically significant.

Conclusion:

CBCT can be a reliable tool in the evaluation of pericoronal follicular space, and the values in different dimensions can be an accurate predictor radiologically for the diagnosis of pathologies when compared to 2D imaging.
The Contemporary Management of Cleft Lip and Palate and the Role of Artificial Intelligence: A Review
Authors: Marya Anand , Venugopal Adith , Karobari Mohmed Isaqali , Chaudhari Prabhat Kumar , Heboyan Artak , Rokaya Dinesh
Published: June 2022

Introduction:

Cleft management is an exhaustive process for the patient, the orthodontist, and the caregiver. In recent decades, a wide number of challenges have been addressed with the inclusion of various dental specialties for the detection, diagnosis, and treatment of orofacial clefts. The orthodontist plays a very pivotal role during the overall management of children with cleft lip and palate as they need to make critical decisions for when to intervene orthodontically and at what stage to set priorities for individual treatment goals.

Objectives:

The objectives of this study were to provide an in-depth review of the evolving role of various disciplines focusing on orthodontics in the management of cleft cases.

Methods:

A general search was carried out to identify the published data on cleft lip and cleft palate management on PubMed and Scopus until the 1st of June 2021 using keywords such as cleft lip, cleft palate, cleft orthodontics, naso-alveolar molding, and surgical cleft orthodontics. The related literature was then reviewed and analyzed.

Results:

With improvements in 3D modeling, CT scans of patients can be used to construct precise 3D models, and these can be utilized to demonstrate various clinical issues related to clefts. The orthodontist has a major role in the various stages and steps, follow-up, treatment care, and outcome assessment. With the advent of technological advancements and artificial intelligence, the role is only going to evolve and expand further in the management of the cleft lip and palate. Diagnostic techniques utilizing artificial intelligence to detect cleft during the prenatal period have also been tested and have been shown to have a high rate of accuracy. The evolution of distraction osteogenesis came into the limelight as a revolutionary modality for cleft treatment. Computer-assisted orthognathic surgery is a widely used modality for reshaping the osseous defects of the maxilla in patients with congenital clefts. With the development of additional modalities such as aligners, patients that need to undergo complex orthognathic surgeries can also be treated with aligners without compromising the outcomes.

Conclusion:

The cleft lip and palate can be managed by a multi-disciplinary team. Orthodontics has an important role in the overall management of a cleft affected individual as they must make critical decisions regarding orthodontic interventions as well as set priorities for each treatment goal. With the advent of technological advancements and artificial intelligence, the diagnosis and management of the cleft lip and palate have become simplified.
Nephrotic Syndrome and Renin-angiotensin System: Pathophysiological
Role and Therapeutic Potential
Authors: Silva Ana Cristina Simões E. , dos Anjos Alessandra Aguiar , de Paiva Isadora Tucci , Simões Lima Giovanna Letícia , da Silva Filha Roberta , Fróes Brunna Pinto E. , Brant Pinheiro Sérgio Veloso
Published: June 2022

Idiopathic Nephrotic Syndrome (INS) is the most frequent etiology of glomerulopathy
in pediatric patients and one of the most common causes of chronic kidney disease (CKD) and
end-stage renal disease (ESRD) in this population. In this review, we aimed to summarize evidence
on the pathophysiological role and therapeutic potential of the Renin-Angiotensin System
(RAS) molecules for the control of proteinuria and for delaying the onset of CKD in patients
with INS. This is a narrative review in which the databases PubMed, Web of Science, and Sci-
ELO were searched for articles about INS and RAS. We selected articles that evaluated the pathophysiological
role of RAS and the effects of the alternative RAS axis as a potential therapy for
INS. Several studies using rodent models of nephropathies showed that the treatment with activators
of the Angiotensin-Converting Enzyme 2 (ACE2) and with Mas receptor agonists reduces
proteinuria and improves kidney tissue damage. Another recent paper showed that the reduction
of urinary ACE2 levels in children with INS correlates with proteinuria and higher concentrations
of inflammatory cytokines, although data with pediatric patients are still limited. The molecules
of the alternative RAS axis comprise a wide spectrum, not yet fully explored, of potential
pharmacological targets for kidney diseases. The effects of ACE2 activators and receptor Mas
agonists show promising results that can be useful for nephropathies including INS.
Miłość i filozofia w muzyce: kantata L’Eraclito amoroso Barbary Strozzi
Authors: Zamara Dominika
Published: June 2022

The article analysis L’Eraclito amoroso, the cantata by the outstanding Barbara Strozzi (1619–1677), one of the few women composers working in Venetia in Baroque. The cantata represents the reception of philosophical ideas in the XVII century vocal music. The relationship between philosophy, music, and poetry is being analyzed, with the primary focus on the image of love presented in work in the context of the philosophical ideas of Heraclitus of Ephesus. In the presentation of the above themes, the author used tools connected to studying music rhetoric, relationships between words and music, as well as, to some degree, musical semiotics.
An Analysis of Different Distance-Linkage Methods for Clustering Gene Expression Data and Observing Pleiotropy: Empirical Study
Authors: Choudhury Joydhriti , Ashraf Faisal Bin
Published: June 2022

Background

Large amounts of biological data have been generated over the last few decades, encouraging scientists to look for connections between genes that cause various diseases. Clustering illustrates such a relationship between numerous species and genes. Finding an appropriate distance-linkage metric to construct clusters from diverse biological data sets has thus become critical. Pleiotropy is also important for a gene’s expression to vary and create varied consequences in living things. Finding the pleiotropy of genes responsible for various diseases has become a major research challenge.

Objective

Our goal was to establish the optimal distance-linkage strategy for creating reliable clusters from diverse data sets and identifying the common genes that cause various tumors to observe genes with pleiotropic effect.

Methods

We considered 4 linking methods—single, complete, average, and ward—and 3 distance metrics—Euclidean, maximum, and Manhattan distance. For assessing the quality of different sets of clusters, we used a fitness function that combines silhouette width and within-cluster distance.

Results

According to our findings, the maximum distance measure produces the highest-quality clusters. Moreover, for medium data set, the average linkage method, and for large data set, the ward linkage method works best. The outcome is not improved by using ensemble clustering. We also discovered genes that cause 3 different cancers and used gene enrichment to confirm our findings.

Conclusions

Accuracy is crucial in clustering, and we investigated the accuracy of numerous clustering techniques in our research. Other studies may aid related works if the data set is similar to ours.
Impacts of Digital Care Programs for Musculoskeletal Conditions on Depression and Work Productivity: Longitudinal Cohort Study
Authors: Costa Fabíola , Janela Dora , Molinos Maria , Moulder Robert , Bento Vírgilio , Lains Jorge , Scheer Justin , Yanamadala Vijay , Cohen Steven , Dias Correia Fernando
Published: June 2022

Background

Comorbidity between musculoskeletal (MSK) pain and depression is highly common, and is associated with a greater symptom burden and greater loss of work productivity than either condition alone. Multimodal care programs tackling both physical and mental health components may maximize productivity recovery and return to work. Digital delivery of such programs can facilitate access, ensure continuity of care, and enhance patient engagement.

Objective

The aim of this study was to assess the impact of a completely remote multimodal digital care program (DCP) for MSK pain on mental health and work-related outcomes stratified by baseline depression levels.

Methods

Ad hoc analysis of an interventional, single-arm, cohort study of individuals with MSK pain undergoing a DCP was performed. Three subgroups with different baseline depression severity levels were established based on responses to the Patient Health Questionnaire (PHQ-9): cluster 1 (score<5: minimal depression), cluster 2 (scores 5-10: mild depression), and cluster 3 (score≥10: moderate depression). The mean changes in depression, anxiety, fear-avoidance beliefs, work productivity, and activity impairment and adherence between baseline and end of program (8-12 weeks) were assessed across subgroups by latent growth curve analysis.

Results

From a total of 7785 eligible participants, 6137 (78.83%) were included in cluster 1, 1158 (14.87%) in cluster 2, and 490 (6.29%) in cluster 3. Significant improvements in depression and anxiety scores were observed in clusters 2 and 3 but not in cluster 1, with average end-of-the program scores in clusters 2 and 3 below the initially defined cluster thresholds (score of 5 and 10, respectively). All clusters reported significant improvements in productivity impairment scores (mean changes from –16.82, 95% CI –20.32 to –13.42 in cluster 1 to –20.10, 95% CI –32.64 to –7.57 in cluster 3). Higher adherence was associated with higher improvements in depression in clusters 2 and 3, and with greater recovery in activities of daily living in cluster 3. Overall patient satisfaction was 8.59/10.0 (SD 1.74).

Conclusions

A multimodal DCP was able to promote improvements in productivity impairment scores comparable to those previously reported in the literature, even in participants with comorbid depression and anxiety. These results reinforce the need to follow a biopsychosocial framework to optimize outcomes in patients with MSK pain.

Trial Registration

ClinicalTrials.gov NCT04092946; https://clinicaltrials.gov/ct2/show/NCT04092946
Acute effects of resistance exercise with blood flow restriction on cardiovascular response: a meta-analysis
Authors: Lemos Leonardo Kesrouani , Toledo Teixeira Filho Carlos Alberto , Biral Taíse Mendes , de Souza Cavina Allysiê Priscilla , Junior Eduardo Pizzo , Oliveira Damasceno Silas de , Vanderlei Franciele Marques
Published: June 2022

Aim:
To compare the acute effects of low-load resistance training associated with blood flow restriction (LLRT-BFR) with low-load resistance training (LLRT) and high-load resistance training (HLRT) on cardiovascular outcomes in healthy individuals.
Methods:
This review was registered and the studies were selected using seven databases. Randomized controlled clinical trials were included that evaluated LLRT-BFR compared with LLRT and HLRT in young individuals for the cardiovascular outcomes.
Results:
19 studies were included. In the comparison of LLRT-BFR with HLRT, there were significant differences for cardiac output and heart rate – with reduced values and in favor of LLRT-BFR.
Conclusion:
There are no greater acute effects of the addition of blood flow restriction, with the exception of the reduction in cardiac output and heart rate for LLRT-BFR compared with HLRT.
Prednisone and deflazacort in Duchenne muscular dystrophy: a patient perspective and plain language summary publication of the Cincinnati study
Authors: Wong Brenda L , Cook Tiffany , Miller Hawken
Published: June 2022

What is this summary about?

This is a summary of an article about the Cincinnati study, which was published in the Journal of Comparative Effectiveness Research in January 2020. The Cincinnati study reviewed data from 435 males with Duchenne muscular dystrophy, also known as DMD, who were treated at the Cincinnati Children's Hospital Medical Center. DMD is a rare disease that worsens over time. People with DMD experience inflammation in their muscles and muscle loss over time. They also experience bone problems such as an abnormally bent spine, also known as scoliosis, as well as heart and lung problems.

What happened in the Cincinnati study?

Prednisone and deflazacort are steroids that help to reduce muscle inflammation and are used as treatments for DMD. The study researchers wanted to further understand the differences between using prednisone and deflazacort in males with DMD by reviewing data from past medical records of patients seen in clinics rather than in clinical studies. This is known as gathering real-world evidence. In the Cincinnati study, the researchers compared males with DMD who started taking prednisone as their first steroid treatment with males who started taking deflazacort as their first steroid treatment.

What were the results?

Overall, the researchers found that the participants who took deflazacort were able to walk until a later age before they needed to use a wheelchair, compared with those who took prednisone. They also had a lower risk of scoliosis and developed it at a later age.

What do the results of the study mean?

These results helped the researchers to learn more about the differences between how well prednisone and deflazacort work in males with DMD based on their medical records.
Factores sociodemográficos y clínicos asociados a la supervivencia de dientes tratados endodónticamente por estudiantes de pregrado. Medellín (Colombia)
Authors: Pineda Vélez Eliana , Madrid Gutiérrez Luis Miguel , Cumplido Mendoza Mario Andrés , Agudelo Suárez Andrés A.
Published: June 2022

Objetivo: Determinar los factores sociodemográficos y clínicos asociados con la supervivencia de dientes tratados endodónticamente por estudiantes de pregrado de la Facultad de OdontologíaUniversidad de Antioquia (Medellín, Colombia), durante el periodo 2007-2011. Material y métodos: Estudio longitudinal retrospectivo con análisis de supervivencia por medio de las historias clínicas según los criterios de inclusión y posteriormente se examinaron a los pacientes. La supervivencia global se calculó utilizando el análisis de Kaplan-Meier, y las curvas se compararon a través del log rank test. Para el análisis multivariado se realizó el modelo de riesgos proporcionales de Cox, obteniendo la medida de asociación HR ajustada, con su intervalo de confianza al 95%. Resultados: Las variables sociodemográficas y clínicas con asociación estadísticamente significativa fueron nivel de educación, tipo de afiliación a salud, diagnóstico inicial y tipo de restauración. Los dientes que permanecen después de un tratamiento endodóntico durante los primeros tres años es del 78% y los que sobreviven por más de seis años es del 57%. La media de sobrevida de los dientes en los pacientes atendidos es de 1,959 días (error estándar de 66.9 días). El modelo multivariado mostró que la velocidad de pérdida del diente fue mayor en multirradiculares (HR 2.38; IC 95% 1.23-4.60) y en aquellos con diagnóstico inicial de absceso apical agudo (HR 27.96; IC 95% 1.84-423.09). Conclusión: Se identificaron factores sociodemográficos y clínicos asociados con la supervivencia de los dientes tratados endodónticamente, lo que permite establecer sistemas de vigilancia epidemiológica para evaluar la calidad de la atención odontológica.
Manejo de residuos peligrosos en el consultorio dental
Authors: Tiol Carrillo Agustín , Gutiérrez Ospina Iván
Published: June 2022

Un residuo peligroso es aquél que, por sus características de infl amabilidad, corrosividad, reactividad, explosividad o infectividad son un riesgo potencial para el equilibrio ecológico o del medio ambiente, y corresponde a la Secretaría de Medio Ambiente y Recursos Naturales (SEMARNAT) su regulación y control como lo específi ca la Ley General del Equilibrio Ecológico y la Protección al Ambiente.
Influencia del silano y adhesivos universales en la adhesión durante la reparación de un cerómero
Authors: Hernández Barragán Diana Carolina , Cruz González Alberto Carlos , Calvo Ramírez Juan Norberto
Published: June 2022

Introducción: No existe un protocolo defi nitivo para la reparación de cerómeros. Los adhesivos universales debido a su composición e indicaciones pueden ser una alternativa dentro de la reparación de restauraciones poliméricas, pero la asociación de los silanos con los adhesivos universales requiere más investigación. Objetivo: Evaluar y comparar la resistencia de unión de dos adhesivos universales en la interfase cerómero-resina, asociado o no a un agente silano. Material y métodos: Se realizaron seis bloques de cerómero y se trataron según las siguientes variables: (A) sin tratamiento, (B) agente silano, (C) adhesivo universal 1 + silano, (D) adhesivo universal 1, (E) adhesivo universal 2 + silano, (F) adhesivo universal 2 (n = 10). Se unió resina compuesta a dichas superfi - cies y se realizó prueba de microtensión. El tipo de falla se evaluó con estereomicroscopio. Resultados: Los valores de resistencia de unión de los grupos fueron estadísticamente diferentes (p < 0.05), excepto entre ambos adhesivos universales evaluados. El grupo B presentó los valores más altos de resistencia adhesiva. Los grupos C y E obtuvieron valores de resistencia adhesiva menores en comparación con los grupos D y F. El tipo de falla predominante fue el adhesivo. Conclusión: El uso asociado de un silano funcional con los adhesivos universales no mejora los valores de resistencia adhesiva, por lo que debería evitarse. Como primera elección se recomienda el silano funcional, y en segundo grado, sólo usar adhesivos universales, pero no asociar los dos materiales en un mismo proceso adhesivo.
Tratamiento alternativo in vitro en sinusitis y neoplasias del seno maxilar
Authors: Landa Román Cristóbal , Gómez Pamatz Francisco Javier , Jaramillo Quezada Virginia
Published: June 2022

El presente artículo está enfocado en demostrar que es factible realizar una comunicación bucosinusal de modo in vitro utilizando cráneos humanos que fueron aportados por el panteón municipal de la ciudad de Morelia. La fi nalidad útil de este procedimiento está enfocada en controlar los síntomas de la sinusitis. Igualmente analizar la posibilidad de ingresar farmacológicamente a la cavidad neumática en casos de crecimientos neoplásicos valiéndonos de las cualidades permeables en la mucosa. Comprobamos que es un estudio experimental, longitudinal, analítico de riesgo mínimo que se implementó de manera in vitro en los segundos premolares o primeros molares permanentes de 10 cráneos de restos humanos. Teniendo como resultado siete abordajes de los cuales el 85.71% se reportó como favorable al procedimiento quirúrgico, demostrando que es un procedimiento adecuado, económico que no requiere equipo sofi sticado.
Caracterización del biotipo facial, caries, hábitos de higiene oral y dieta alimenticia en originarios de Lenca de Intibucá, Honduras
Authors: Valle Galo Ericka Elizabeth , Serrano Barahona Danilo Humberto , Herrera Paz Edwin Francisco , Rivas Menjivar Jessica Mireya , Rohany Moncada Farideh Beatriz , Ponce Oliva Lucy María , Aguirre Cerrato Heidy Jackeline , Tábora Reyes Jennyfer Larissa , Arguello Lacayo Lucia , Leiva Fernández Maryorie Michelle , Alvarenga Fortín Gracia María , Mejía Rivas Ilma Rosario , Pineda Turcios Lía Ruth
Published: June 2022

Objetivo: Determinar la prevalencia de caries, hábitos de higiene oral, biotipo facial y la dieta alimenticia en la comunidad Lenca de la aldea Mixcure, departamento de Intibucá, Honduras. Material y métodos: Se aplicaron encuestas a 76 personas, en edades de 2-64 años, y se realizó evaluación clínica intra-/extraoral. El estudio tiene enfoque cuantitativo de alcance exploratorio descriptivo, diseño no experimental trasversal. Resultados: El biotipo facial predominante fue el leptoprosopo (43%). La comunidad Lenca de Mixcure presenta una dieta alta en carbohidratos, hábitos de higiene oral pobres; frecuencias de cepillado de una (42%) y dos veces al día (22%), así como el uso de auxiliares de limpieza oral caseros tales como carbón y sal. Se encontró presencia de caries en el 100% de la población estudiada, siendo la dentición posterior la más afectada. El índice CPO-D para la población en general fue de 13.9 (riesgo muy elevado). En individuos con dentición permanente, el índice CPO-D fue de 16.27 con predominio de caries en género femenino; en individuos con dentición decidua el índice CEO fue de 6.45 y en dentición mixta el índice CPO-D fue de 19. Conclusiones: Los resultados demuestran una alta prevalencia de caries en la comunidad Lenca de Mixcure, según criterios de la OMS, debido a varios factores, entre ellos la poca atención odontológica disponible en la región, la falta de nutrientes en su dieta, higiene defi ciente que conlleva a la acumulación de placa bacteriana, y por ende a una pérdida dental temprana y alteraciones funcionales.
La importancia de las Revistas Científicas. Una nueva era para la Revista Odontológica Mexicana
Authors: Leyva Huerta Elba Rosa , Gaitán Cepeda Luis Alberto
Published: June 2022

La generación de nuevo conocimiento siempre tiene como principal objetivo aumentar la esperanza de vida, eliminar el dolor y en consecuencia mejorar la calidad de vida de los seres humanos. La generación de conocimiento inicia con una pregunta sustentada en un problema que afecta a una población específica y que es necesario resolver. Por lo que la investigación contribuye a una comprensión de un problema que eventualmente impacta en la calidad de vida de esa población.
Endocarditis prophylaxis in dental practice: Evaluation of knowledge among dental students, paediatric dentistry residents and specialists in paediatric dentistry
Authors: Pierdant-Pérez Mauricio , Peñuelas-Solano Elizabeth , Butrón-Téllez Girón Claudia , Guzmán-Uribe Daniela , Ramírez-Carrasco Alejandra
Published: June 2022

Objective:Our aim was to determine the degree of knowledge about endocarditis prophylaxis (EP) among dental students, paediatric dentistry residents and specialists in paediatric dentistry, and to identify required attention areas.Material and methods: A cross-sectional study with 155 participants divided into three study groups was given a questionnaire to evaluate the knowledge of endocarditis prophylaxis, consisting of three areas: dental procedures, dose/medication and heart condition. Data were analysed with analysis of variance (ANOVA), using generalized linear models.Results: We stratified EP knowledge in three areas: dental procedures (no differences), dose/medication (statistically significant difference between group 2 and 3 (84.62 % vs. 38.89%, p = 0.044) and heart condition (no differences but low (35.48%, 53.85%, and 44.44%). Conclusions: This study was able to identify the knowledge degree of inadequate dental procedures in groups, having a greater knowledge in dose/medications those in paediatric dentistry residents. The area that requires more attention and reinforcement of the three groups is the one on heart condition area. Therefore it’s necessary to reinforce the endocarditis prophylaxis knowledge in undergraduate and postgraduate programs; and encourage paediatric dentistry to keep up-to-date on this issue.
Carcinoma sarcomatoide vs melanoma maligno amelanótico en paladar. Estudio patológico e inmunohistoquímico de un caso
Authors: Carrioni C , Urbano del Valle S , Tovío Martínez E , Herrera Lomonaco S
Published: June 2022

El carcinoma sarcomatoide y el melanoma maligno amelanótico son neoplasias malignas de muy baja prevalencia en la región de cabeza y cuello; sin embargo, son de comportamiento agresivo y muy mal pronóstico. Aunque se consideran enfermedades similares, no es suficiente el estudio histopatológico, ni el examen clínico. Es importante y fundamental el estudio inmunohistoquímico para confirmar la enfermedad presente. Se reporta el caso de un carcinoma sarcomatoide que se presenta como tumor primario a nivel de sector anterior y medio de paladar duro de un hombre de 79 años de edad. En primera instancia, clínicamente se plantea como diagnóstico diferencial carcinoma escamocelular; sin embargo, los hallazgos morfológicos tras la biopsia, muestran un tumor maligno de alto grado histológico. Se discute la posible etiología de la lesión, comportamiento, enfermedad y diagnóstico.
Estimación de la cantidad de trióxido de bismuto como agente radiopacificador en dos cementos minerales trióxido agregado mediante una prueba de radiopacidad
Authors: Flores Ledesma Abigailt , Gutiérrez Estrada Kenya , Bucio Galindo Lauro
Published: June 2022

Se dice que el cemento mineral trióxido agregado (MTA) contiene 20%wt de trióxido de bismuto (Bi2 O3 ) que le provee radiopacidad; sin embargo, la radiopacidad reportada en varias marcas de estos cementos ha sido variable, lo que sugiere que presentan diversa cantidad de bismuto, pudiendo afectar sus propiedades mecánicas. Objetivo: Estimar la concentración de trióxido de bismuto en dos marcas comerciales disponibles en México a partir de una prueba de radiopacidad. Material y métodos: cinco mezclas de cemento portland blanco (CPB) con concentraciones de Bi2 O3 al 0, 10, 15, 20 y 25%wt (CPB, Bi10%, Bi15%, Bi20%, Bi25%), se analizaron dos lotes de dos cementos comerciales: MTA Angelus y MTA Viardent mediante una prueba de radiopacidad de acuerdo a la ISO 6876. Estos valores fueron determinados con base en la densidad radiográfica (tonos de grises) y convertidos a milímetros de aluminio (mm Al); se realizó un ajuste lineal con las mezclas del CPB y bismuto; se utilizó la ecuación de la recta para calcular la concentración de Bi2 O3 en los cementos comerciales. Resultados: Se observó aumento de radiopacidad a mayor cantidad de trióxido de bismuto, el CPB obtuvo una radiopacidad de 1.8 mm Al, mientas que en el Bi25% fue de 6 mm Al. La concentración de 20%wt se usó como control, se observaron diferencias estadísticamente significativas en Bi15%, Bi10%, cemento Portland blanco y MTA Angelus (p < 0.05). En el MTA Viardent la cantidad de bismuto es de 24-25%wt, mientras que el MTA Angelus presenta entre 20-32%wt. Conclusiones: Los cementos comerciales muestran una concentración de bismuto mayor que la sugerida, lo que aumenta la radiopacidad de éstos, pudiendo afectar las propiedades mecánicas.
Mecanismos inflamatorios en la destrucción periodontal
Authors: Solís Suárez Diana Laura , Pérez Martínez Isaac Obed , García Hernández Ana Lilia
Published: June 2022

La enfermedad periodontal se inicia por la presencia de bacterias. Sin embargo, la inflamación es la principal causa de su cronicidad y la destrucción de los tejidos periodontales, principalmente del hueso alveolar que conduce al edentulismo. Los mecanismos que llevan a la destrucción de los tejidos incluyen el incremento no regulado de mediadores inflamatorios y alteraciones en los mecanismos de resolución de la inflamación. El carácter silencioso e indoloro de la patología ocasiona que el padecimiento sea ignorado permitiendo su evolución a cuadros crónicos y severos, por lo que su incidencia es alta. La presente revisión describe los mecanismos moleculares y celulares de la inflamación durante el progreso de la EP, así como su participación en la destrucción de los tejidos de soporte. El conocimiento de la patogénesis de la EP con base en la inflamación crónica podría brindar opciones terapéuticas novedosas para la reducción de la EP y sus repercusiones.
Formación para la investigación y la educación científica en odontología, mediante el uso de la simulación numérica
Authors: Hernández Vázquez Rosa Alicia , Romero Ángeles Beatriz , Urriolagoitia Sosa Guillermo , Marquet Rivera Rodrigo Arturo , Mastache Miranda Octavio Alejandro , Urriolagoitia Calderón Guillermo
Published: June 2022

El surgimiento de la investigación en odontología, como disciplina independiente de la medicina y otras áreas del campo de las Ciencias de la Salud, es relativamente reciente. Desafortunadamente en México la investigación no es la base de la formación profesional y únicamente instituciones públicas como la UNAM, el IPN o la UAM son las que fomentan la formación científica en la mayoría de las escuelas y facultades de odontología del país.