bluuebunny/crossref_metadata_2025 huggingface dataset:
Elevated Cytokine Levels in Aqueous Humor Are Associated with Peripheral Anterior Synechiae after Penetrating Keratoplasty
Authors: Kusano Yuki , Yamaguchi Takefumi , Nishisako Sota , Matsumura Takehiro , Fukui Masaki , Higa Kazunari , Inoue Toshihiro , Shimazaki Jun
Published: November 2021

Peripheral anterior synechiae (PAS) after corneal transplantation leads to refractory glaucoma and permanent loss of vision. However, the exact mechanism remains elusive. This study aimed to evaluate the association between cytokine levels in the aqueous humor (AqH) and the progression of PAS after penetrating keratoplasty (PKP). We measured 20 cytokine levels in AqH and assessed the correlation with PAS progression after PKP in 85 consecutive patients who underwent PKP. We also evaluated age-dependent alterations in PAS and cytokine levels in DBA2J mice. PAS developed in 38 (44.7%) of 85 eyes after PKP. The incidence of intraocular pressure increase after PKP was significantly greater in eyes with PAS (26.3%) than in those without PAS (2%, p = 0.0009). The PAS area at 12 months after PKP was significantly positively correlated with the preoperative levels of interleukin (IL)-6, interferon (IFN)-γ and monocyte chemotactic protein (MCP)-1 (p ≤ 0.049). In the DBA2J mice, an experimental glaucoma model that developed PAS at 50 weeks, the AqH levels of IL-2, IL-6, IL-10, IFN-γ, tumor necrosis factor-α, MCP-1 and granulocyte-macrophage colony-stimulating factor (GM-CSF) significantly increased at 50 weeks compared to 8 weeks (p ≤ 0.021). In conclusion, inflammatory alterations in the AqH microenvironment, such as high preoperative specific cytokine levels, can lead to PAS formation and glaucoma.
TRPA1-Mediated Src Family Kinases Activity Facilitates Cortical Spreading Depression Susceptibility and Trigeminovascular System Sensitization
Authors: Nie Lingdi , Jiang Liwen , Quinn John , Grubb Blair , Wang Minyan
Published: November 2021

Transient receptor potential ankyrin 1 (TRPA1) plays a role in migraine and is proposed as a promising target for migraine therapy. However, TRPA1-induced signaling in migraine pathogenesis is poorly understood. In this study, we explored the hypothesis that Src family kinases (SFKs) transmit TRPA1 signaling in regulating cortical spreading depression (CSD), calcitonin gene-related peptide (CGRP) release and neuroinflammation. CSD was monitored in mouse brain slices via intrinsic optical imaging, and in rats using electrophysiology. CGRP level and IL-1β gene expression in mouse trigeminal ganglia (TG) was detected using Enzyme-linked Immunosorbent Assay and Quantitative Polymerase Chain Reaction respectively. The results showed a SFKs activator, pYEEI (EPQY(PO3H2)EEEIPIYL), reversed the reduced cortical susceptibility to CSD by an anti-TRPA1 antibody in mouse brain slices. Additionally, the increased cytosolic phosphorylated SFKs at Y416 induced by CSD in rat ipsilateral cerebral cortices was attenuated by pretreatment of the anti-TRPA1 antibody perfused into contralateral ventricles. In mouse TG, a SFKs inhibitor, saracatinib, restored the CGRP release and IL-1β mRNA level increased by a TRPA1 activator, umbellulone. Moreover, umbellulone promoted SFKs phosphorylation, which was reduced by a PKA inhibitor, PKI (14–22) Amide. These data reveal a novel mechanism of migraine pathogenesis by which TRPA1 transmits signaling to SFKs via PKA facilitating CSD susceptibility and trigeminovascular system sensitization.
Extracellular Matrix Remodeling by Fibroblast-MMP14 Regulates Melanoma Growth
Authors: Pach Elke , Kümper Maike , Fromme Julia E. , Zamek Jan , Metzen Fabian , Koch Manuel , Mauch Cornelia , Zigrino Paola
Published: November 2021

Maintaining a balanced state in remodeling the extracellular matrix is crucial for tissue homeostasis, and this process is altered during skin cancer progression. In melanoma, several proteolytic enzymes are expressed in a time and compartmentalized manner to support tumor progression by generating a permissive environment. One of these proteases is the matrix metalloproteinase 14 (MMP14). We could previously show that deletion of MMP14 in dermal fibroblasts results in the generation of a fibrotic-like skin in which melanoma growth is impaired. That was primarily due to collagen I accumulation due to lack of the collagenolytic activity of MMP14. However, as well as collagen I processing, MMP14 can also process several extracellular matrices. We investigated extracellular matrix alterations occurring in the MMP14-deleted fibroblasts that can contribute to the modulation of melanoma growth. The matrix deposited by cultured MMP14-deleted fibroblast displayed an antiproliferative and anti-migratory effect on melanoma cells in vitro. Analysis of the secreted and deposited-decellularized fibroblast’s matrix identified a few altered proteins, among which the most significantly changed was collagen XIV. This collagen was increased because of post-translational events, while de novo synthesis was unchanged. Collagen XIV as a substrate was not pro-proliferative, pro-migratory, or adhesive, suggesting a negative regulatory role on melanoma cells. Consistent with that, increasing collagen XIV concentration in wild-type fibroblast-matrix led to reduced melanoma proliferation, migration, and adhesion. In support of its anti-tumor activity, enhanced accumulation of collagen XIV was detected in peritumoral areas of melanoma grown in mice with the fibroblast’s deletion of MMP14. In advanced human melanoma samples, we detected reduced expression of collagen XIV compared to benign nevi, which showed a robust expression of this molecule around melanocytic nests. This study shows that loss of fibroblast-MMP14 affects melanoma growth through altering the peritumoral extracellular matrix (ECM) composition, with collagen XIV being a modulator of melanoma progression and a new proteolytic substrate to MMP14.
Extracellular Vesicles Physiological Role and the Particular Case of Disease-Spreading Mechanisms in Polyglutamine Diseases
Authors: Moreira Ricardo , Mendonça Liliana S. , Pereira de Almeida Luís
Published: November 2021

Recent research demonstrated pathological spreading of the disease-causing proteins from one focal point across other brain regions for some neurodegenerative diseases, such as Parkinson’s and Alzheimer’s disease. Spreading mediated by extracellular vesicles is one of the proposed disease-spreading mechanisms. Extracellular vesicles are cell membrane-derived vesicles, used by cells for cell-to-cell communication and excretion of toxic components. Importantly, extracellular vesicles carrying pathological molecules, when internalized by “healthy” cells, may trigger pathological pathways and, consequently, promote disease spreading to neighboring cells. Polyglutamine diseases are a group of genetic neurodegenerative disorders characterized by the accumulation of mutant misfolded proteins carrying an expanded tract of glutamines, including Huntington’s and Machado–Joseph disease. The pathological spread of the misfolded proteins or the corresponding mutant mRNA has been explored. The understanding of the disease-spreading mechanism that plays a key role in the pathology progression of these diseases can result in the development of effective therapeutic approaches to stop disease progression, arresting the spread of the toxic components and disease aggravation. Therefore, the present review’s main focus is the disease-spreading mechanisms with emphasis on polyglutamine diseases and the putative role played by extracellular vesicles in this process.
Cross Pharmacological, Biochemical and Computational Studies of a Human Kv3.1b Inhibitor from Androctonus australis Venom
Authors: Maatoug Sonia , Cheikh Amani , Khamessi Oussema , Tabka Hager , Landoulsi Zied , Guigonis Jean-Marie , Diochot Sylvie , Bendahhou Saïd , Benkhalifa Rym
Published: November 2021

The voltage-gated K+ channels Kv3.1 display fast activation and deactivation kinetics and are known to have a crucial contribution to the fast-spiking phenotype of certain neurons. AahG50, as a natural product extracted from Androctonus australis hector venom, inhibits selectively Kv3.1 channels. In the present study, we focused on the biochemical and pharmacological characterization of the component in AahG50 scorpion venom that potently and selectively blocks the Kv3.1 channels. We used a combined optimization through advanced biochemical purification and patch-clamp screening steps to characterize the peptide in AahG50 active on Kv3.1 channels. We described the inhibitory effect of a toxin on Kv3.1 unitary current in black lipid bilayers. In silico, docking experiments are used to study the molecular details of the binding. We identified the first scorpion venom peptide inhibiting Kv3.1 current at 170 nM. This toxin is the alpha-KTx 15.1, which occludes the Kv3.1 channel pore by means of the lysine 27 lateral chain. This study highlights, for the first time, the modulation of the Kv3.1 by alpha-KTx 15.1, which could be an interesting starting compound for developing therapeutic biomolecules against Kv3.1-associated diseases.
Garlic Volatile Diallyl Disulfide Induced Cucumber Resistance to Downy Mildew
Authors: Yang Fan , Wang Hui , Zhi Chengchen , Chen Birong , Zheng Yujie , Qiao Lijun , Gao Jingcao , Pan Yupeng , Cheng Zhihui
Published: November 2021

Allicin compositions in garlic are used widely as fungicides in modern agriculture, in which diallyl disulfide (DADS) is a major compound. Downy mildew, caused by Pseudoperonospora cubensis (P. cubensis), is one of the most destructive diseases and causes severe yield losses in cucumbers. To explore the potential mechanism of DADS-induced cucumber resistance to downy mildew, cucumber seedlings were treated with DADS and then inoculated with P. cubensis at a 10-day interval. Symptom observation showed that DADS significantly induced cucumber resistance to downy mildew. Furthermore, both lignin and H2O2 were significantly increased by DADS treatment to responding P. cubensis infection. Simultaneously, the enzyme activities of peroxidase (POD) in DADS-treated seedlings were significantly promoted. Meanwhile, both the auxin (IAA) and salicylic acid (SA) contents were increased, and their related differentially expressed genes (DEGs) were up-regulated when treated with DADS. Transcriptome profiling showed that many DEGs were involved in the biological processes of defense responses, in which DEGs on the pathways of ‘phenylpropanoid biosynthesis’, ‘phenylalanine metabolism’, ‘MAPK signaling’, and ‘plant hormone signal transduction’ were significantly up-regulated in DADS-treated cucumbers uninoculated with the pathogen. Based on the results of several physiological indices and transcriptomes, a potential molecular mechanism of DADS-induced cucumber resistance to downy mildew was proposed and discussed. The results of this study might give new insight into the exploration of the induced resistance mechanism of cucumber to downy mildew and provide useful information for the subsequent mining of resistance genes in cucumber.
Epigenotype, Genotype, and Phenotype Analysis of Taiwanese Patients with Silver–Russell Syndrome
Authors: Lin Hsiang-Yu , Lee Chung-Lin , Fran Sisca , Tu Ru-Yi , Chang Ya-Hui , Niu Dau-Ming , Chang Chia-Ying , Chiu Pao-Chin , Chou Yen-Yin , Hsiao Hui-Pin , Tsai Meng-Che , Chao Mei-Chyn , Tsai Li-Ping , Yang Chia-Feng , Su Pen-Hua , Pan Yu-Wen , Lee Chen-Hao , Chu Tzu-Hung , Chuang Chih-Kuang , Lin Shuan-Pei
Published: November 2021

Background: Silver–Russell syndrome (SRS) is a clinically and genetically heterogeneous disorder characterized by severe intrauterine growth retardation, poor postnatal growth, characteristic facial features, and body asymmetry. Hypomethylation of the imprinted genes of the chromosome 11p15.5 imprinting gene cluster and maternal uniparental disomy of chromosome 7 (mUPD7) are the major epigenetic disturbances. The aim of this study was to characterize the epigenotype, genotype, and phenotype of these patients in Taiwan. Methods: Two hundred and six subjects with clinically suspected SRS were referred for diagnostic testing, which was performed by profiling the methylation of H19-associated imprinting center (IC) 1 and the imprinted PEG1/MEST region using methylation-specific multiplex ligation-dependent probe amplification and high-resolution melting analysis with a methylation-specific polymerase chain reaction assay. We also applied a whole genome strategy to detect copy number changes and loss of heterozygosity. Clinical manifestations were recorded and analyzed according to the SRS scoring system proposed by Bartholdi et al. Results: Among the 206 referred subjects, 100 were classified as having a clinical diagnosis of SRS (score ≥ 8, maximum = 15) and 106 had an SRS score ≤ 7. Molecular lesions were detected in 45% (45/100) of the subjects with a clinical diagnosis of SRS, compared to 5% (5/106) of those with an SRS score ≤ 7. Thirty-seven subjects had IC1 hypomethylation, ten subjects had mUPD7, and three subjects had microdeletions. Several clinical features were found to be statistically different (p < 0.05) between the “IC1 hypomethylation” and “mUPD7” groups, including relative macrocephaly at birth (89% vs. 50%), triangular shaped face (89% vs. 50%), clinodactyly of the fifth finger (68% vs. 20%), and SRS score (11.4 ± 2.2 vs. 8.3 ± 2.5). Conclusions: The SRS score was positively correlated with the molecular diagnosis rate (p < 0.001). The SRS subjects with mUPD7 seemed to have fewer typical features and lower SRS scores than those with IC1 hypomethylation. Careful clinical observation and timely molecular confirmation are important to allow for an early diagnosis and multidisciplinary management of these patients.
Is the Median Hourly Ambulatory Heart Rate Range Helpful in Stratifying Mortality Risk among Newly Diagnosed Atrial Fibrillation Patients?
Authors: Chen Hsing-Yu , Malik John , Wu Hau-Tieng , Wang Chun-Li
Published: November 2021

Background: The application of heart rate variability is problematic in patients with atrial fibrillation (AF). This study aims to explore the associations between all-cause mortality and the median hourly ambulatory heart rate range (AHRR˜24hr) compared with other parameters obtained from the Holter monitor in patients with newly diagnosed AF. Material and Methods: A total of 30 parameters obtained from 521 persistent AF patients’ Holter monitor were analyzed retrospectively from 1 January 2010 to 31 July 2014. Every patient was followed up to the occurrence of death or the end of 30 June 2017. Results:AHRR˜24hr was the most feasible Holter parameter. Lower AHRR˜24hr was associated with increased risk of all-cause mortality (adjusted hazard ratio [aHR] for every 10-bpm reduction: 2.70, 95% confidence interval [CI]: 1.75–4.17, p < 0.001). The C-statistic of AHRR˜24hr alone was 0.707 (95% CI: 0.658–0.756), and 0.697 (95% CI: 0.650–0.744) for the CHA2DS2-VASc score alone. By combining AHRR˜24hr with the CHA2DS2-VASc score, the C-statistic could improve to 0.764 (95% CI: 0.722–0.806). While using 20 bpm as the cut-off value, the aHR was 3.66 (95% CI: 2.05–6.52) for patients with AHRR˜24hr < 20 bpm in contrast to patients with AHRR˜24hr ≥ 20 bpm. Conclusions:AHRR˜24hr could be helpful for risk stratification for AF in addition to the CHA2DS2-VASc score.
Current Treatment Options for REM Sleep Behaviour Disorder
Authors: Jiménez-Jiménez Félix Javier , Alonso-Navarro Hortensia , García-Martín Elena , Agúndez José A. G.
Published: November 2021

The symptomatic treatment of REM sleep behaviour disorder (RBD) is very important to prevent sleep-related falls and/or injuries. Though clonazepam and melatonin are usually considered the first-line symptomatic therapy for RBD, their efficiency has not been proven by randomized clinical trials. The role of dopamine agonists in improving RBD symptoms is controversial, and rivastigmine, memantine, 5-hydroxytryptophan, and the herbal medicine yokukansan have shown some degree of efficacy in short- and medium-term randomized clinical trials involving a low number of patients. The development of potential preventive therapies against the phenoconversion of isolated RBD to synucleinopathies should be another important aim of RBD therapy. The design of long-term, multicentre, randomized, placebo-controlled clinical trials involving a large number of patients diagnosed with isolated RBD with polysomnographic confirmation, directed towards both symptomatic and preventive therapy for RBD, is warranted.
Unleveraged Portfolios and Pure Allocation Return
Authors: Alemanni Barbara , Maggi Mario , Uberti Pierpaolo
Published: November 2021

In asset management, the portfolio leverage affects performance, and can be subject to constraints and operational limitations. Due to the possible leverage aversion of the investors, the comparison between portfolio performances can be incomplete or misleading. We propose a procedure to unleverage the mean-variance efficient portfolios to satisfy a leverage requirement. We obtain a class of unleveraged portfolios that are homogeneous in terms of leverage, so therefore properly comparable. The proposed unleverage procedure permits isolating the pure allocation return, i.e., the return component, due to the qualitative choice of portfolio allocation, from the return component due to the portfolio leverage. Theoretical analysis and empirical evidence on actual data show that efficient mean-variance portfolios, once unleveraged, uncover mean-variance dominance relations hidden by the leverage contribution to portfolio return. Our approach may be useful to practitioners proposing to take long positions on “short assets” (e.g. inverse ETF), thereby considering short positions as active investment choices, in contrast with the usual interpretation where are used to overweight long positions.
High-Grade Limbs Open Fractures: Time to Find Milestones in the Emergency Setting
Authors: Altomare Michele , Granieri Stefano , Cioffi Stefano Piero Bernardo , Spota Andrea , Basilicò Silvia Azisa , Chiara Osvaldo , Cimbanassi Stefania
Published: November 2021

(1) Background: The Gustilo–Anderson (G/A) grading system is a universally accepted tool used to classify high-grade limb open fractures. The purpose of this study is to find early independent predictors of amputation in emergency settings. (2) Methods: A retrospective analysis involving patients treated at our center between 2010 and 2016 was conducted. Patients with at least one G/A grade III fracture or post-traumatic amputation were included. Three groups were identified: G/A IIIA (A group), G/A IIIB-C (BC group), and Amputation group (AMP group). Each group was further divided into two subgroups considering timing of coverage (early vs. delayed). Univariate and multivariate logistic regression models were developed to identify independent predictors of the limb’s outcome. (3) Results: One-hundred-six patients with G/A III A-B-C fractures or amputation of the affected limb were selected from the Niguarda Hospital Trauma Registry. The patients were divided into the A group (26), BC group (66), and AMP group (14). The rate of infectious complications following early or delayed coverage was evaluated: A group, 9.1% vs. 66.7% (p > 0.05); BC group, 32% vs. 63.6% (p = 0.03); and AMP group, 22% vs. 18.5% (p > 0.05). After further recategorization, the BC subgroups were analyzed: multivariate logistic regression model identified systolic blood pressure (SBP) <90 mmHg (p = 0.03) and Mangled Extremity Severity Score MESS ≥ 7 (p = 0.001) were determined to be independent predictors of limb amputation. (4) Conclusion: MESS and SBP serve as predictors of amputation. Based on the results, we propose a new management algorithm for mangled extremities. Early coverage is related to lower rates of infectious complications. Referral to high-volume centers with specific expertise is mandatory to guarantee the best results.
Band Gap of Pb(Fe0.5Nb0.5)O3 Thin Films Prepared by Pulsed Laser Deposition
Authors: Bartek Nicole , Shvartsman Vladimir V. , Bouyanfif Houssny , Schmitz Alexander , Bacher Gerd , Olthof Selina , Sirotinskaya Svetlana , Benson Niels , Lupascu Doru C.
Published: November 2021

Ferroelectric materials have gained high interest for photovoltaic applications due to their open-circuit voltage not being limited to the band gap of the material. In the past, different lead-based ferroelectric perovskite thin films such as Pb(Zr,Ti)O3 (Pb,La)(Zr,Ti)O3 and PbTiO3 were investigated with respect to their photovoltaic efficiency. Nevertheless, due to their high band gaps they only absorb photons in the UV spectral range. The well-known ferroelectric PbFe0.5Nb0.5O3 (PFN), which is in a structure similar to the other three, has not been considered as a possible candidate until now. We found that the band gap of PFN is around 2.75 eV and that the conductivity can be increased from 23 S/µm to 35 S/µm during illumination. The relatively low band gap value makes PFN a promising candidate as an absorber material.
Recent Advances in Multi-Functional Coatings for Soft Magnetic Composites
Authors: Pošković Emir , Franchini Fausto , Ferraris Luca , Fracchia Elisa , Bidulska Jana , Carosio Federico , Bidulsky Robert , Actis Grande Marco
Published: November 2021

During the past 50 years, the aim to reduce the eddy current losses in magnetic cores to a minimum led to the formulation of new materials starting from electrically insulated iron powders, today called Soft Magnetic Composites (SMC). Nowadays, this promising branch of materials is still held back by the mandatory tradeoff between energetic, electrical, magnetic, and mechanical performances. In most cases, the research activity focuses on the deposition of an insulating/binding layer, being one of the critical points in optimizing the final composite. This insulation usually is achieved by either inorganic or organic layer constituents. The main difference is the temperature limit since most inorganic materials typically withstand higher treatment temperatures. As a result, the literature shows many materials and process approaches, each one designed to meet a specific application. The present work summarizes the recent advances in state of the art, analyzing the relationship among material compositions and magnetic and mechanical properties. Each coating shows its own processing sets, which vary from simple mechanical mixing to advanced chemical methods to metallurgical treatments. From state of the art, Aluminum coatings are characterized by higher current losses and low mechanical properties. In contrast, higher mechanical properties are obtained by adopting Silicon coatings. The phosphates coatings show the best-balanced overall properties. Each coating type was thoroughly investigated and then compared with the literature background highlighting. The present paper thus represents a critical overview of the topic that could serve as a starting point for the design and development of new and high-performing coating solutions for SMCs. However, global research activity continuously refines the recipes, introducing new layer materials. The following steps and advances will determine whetherthese materials breakthrough in the market.
Laser Desorption/Ionization Mass Spectrometry as a Potential Tool for Evaluation of Hydroxylation Degree of Various Types of Titanium Dioxide Materials
Authors: Kasperkowiak Małgorzata , Kurowska Monika , Zalas Maciej , Frański Rafał
Published: November 2021

For many applications, TiO2 must have a unique surface structure responsible for its desirable physicochemical properties. Therefore the fast and easy methods of TiO2 surface characterization are of great interest. Heated TiO2 samples and dye-modified TiO2 samples were analyzed by laser desorption/ionization mass spectrometry. In the negative ion mode, two types of ions were detected, namely (TiO2)n− and (TiO2)nOH−. It has been established that the samples can be differentiated based on the relative ion abundances, especially with respect to the free hydroxyl group population. It indicates that laser desorption ionization mass spectrometry has the potential for the investigation of the surface properties of various TiO2 materials.
Analysis and Modification of Methods for Calculating Axial Load Capacity of High-Strength Steel-Reinforced Concrete Composite Columns
Authors: Wang Jun , Duan Yuxin , Wang Yifan , Wang Xinran , Liu Qi
Published: November 2021

To investigate the applicability of the methods for calculating the bearing capacity of high-strength steel-reinforced concrete (SRC) composite columns according to specifications and the effect of confinement of stirrups and steel on the bearing capacity of SRC columns. The axial compression tests were conducted on 10 high-strength SRC columns and 4 ordinary SRC columns. The influences of the steel strength grade, the steel ratio, the types of stirrups and slenderness ratio on the bearing capacity of such members were examined. The analysis results indicate that using high-strength steel and improving the steel ratio can significantly enhance the bearing capacity of the SRC columns. When the slenderness ratio increases dramatically, the bearing capacity of the SRC columns plummets. As the confinement effect of the stirrups on the concrete improves, the utilization ratio of the high-strength steel in the SRC columns increases. Furthermore, the results calculated by AISC360-19(U.S.), EN1994-1-1-2004 (Europe), and JGJ138-2016(China) are too conservative compared with test results. Finally, a modified formula for calculating the bearing capacity of the SRC columns is proposed based on the confinement effect of the stirrups and steel on concrete. The results calculated by the modified formula and the finite element modeling results based on the confinement effect agree well with the test results.
Copper Electroless Metallization of Cellulose Paper via Polydopamine Coating and Silver Catalyst
Authors: Moraczewski Krzysztof , Trafarski Andrzej , Malinowski Rafał
Published: November 2021

The paper presents the results of copper electroless metallization of cellulose paper with the use of a polydopamine coating and silver catalyst. The polydopamine coating was deposited via a simple dip method using a dopamine hydrochloride solution in 10 mM TRIS-HCl buffer with a pH of 8.5. The research showed that as a result of this process, cellulose fibers were covered with a homogeneous layer of polydopamine. The unique properties of the polydopamine coating allowed the reduction of silver ions from silver nitrate solution and the deposition of silver atoms on the paper surface. Deposited silver served as a catalyst in the autocatalytic electroless copper-plating process. The copper layer covered the entire surface of the paper sheet after 5 min of metallization, favorably affecting the electrical properties of this material by lowering the surface resistivity. The deposited copper layer was further characterized by good adhesive strength and high susceptibility to deformation.
Thermo-Physiological Comfort Properties of Sportswear with Different Combination of Inner and Outer Layers
Authors: Atalie Desalegn , Tesinova Pavla , Tadesse Melkie Getnet , Ferede Eyasu , Dulgheriu Ionuț , Loghin Emil
Published: November 2021

Consumers expect high-performance functionality from sportswear. To meet athletic and leisure-time activity requirements, further research needs to be carried out. Sportswear layers and their specific thermal qualities, as well as the set and air layer between materials, are all important factors in sports clothing. This research aims to examine the thermal properties of sports fabrics, and how they are affected by structure parameters and maintained with different layers. Three inner and four outer layers of fabric were used to make 12 sets of sportswear in this study. Before the combination of outer and inner layers, thermal properties were measured for each individual layer. Finally, the thermal resistance, thermal conductivity, thermal absorptivity, peak heat flow density ratio, stationary heat flow density, and water vapor permeability of bi-layered sportswear were evaluated and analyzed. The findings show that sportswear made from a 60% cotton/30% polyester/10% elastane inner layer and a 100% polyester outer layer had the maximum thermal resistance of 61.16 (×103 K·m2 W−1). This performance was followed by the sample made from a 90% polyester/10% elastane inner layer and a 100% polyester outer layer, and the sample composed of a 100% elastane inner layer and a 100% polyester outer layer, which achieved a thermal resistance value of 60.41 and 59.41 (×103 K·m2 W−1), respectively. These results can be explained by the fact that thicker textiles have a higher thermal resistance. This high-thermal-resistance sportswear fabric is appropriate for the winter season. Sportswear with a 90% polyester/10% elastane inner layer had worse water vapor resistance than sportswear with a 60% cotton/30% polyester/10% elastane and a 100% elastane layer. Therefore, these sports clothes have a higher breathability and can provide the wearers with very good comfort. According to the findings, water vapor permeability of bi-layered sportswear is influenced by geometric characteristics and material properties.
Analysis of Changes in the Tensile Bond Strenght of Soft Relining Material with Acrylic Denture Material
Authors: Wyszyńska Magdalena , Białożyt-Bujak Ewa , Chladek Grzegorz , Czelakowska Aleksandra , Rój Rafał , Białożyt Agata , Gruca Olaf , Nitsze-Wierzba Monika , Kasperski Jacek , Skucha-Nowak Małgorzata
Published: November 2021

Abrasions and pressure ulcers on the oral mucosa are most often caused by excessive pressure or incorrect fitting of the denture. The use of soft relining materials can eliminate pain sensations and improve patient comfort. The main functional feature of soft elastomeric materials is the ability to discharge loads from the tissues of the mucosa. (1) Background: The aim of the work was a comparative laboratory study of ten materials used for the soft lining of acrylic dentures. (2) Methods: There were materials based on acrylates (Vertex Soft, Villacryl Soft, Flexacryl Soft) and silicones (Sofreliner Tough Medium, Sofreliner Tough Medium, Ufi Gel SC, GC Reline Soft, Elite Soft Relining, Molloplast). Laboratory tests include the analysis of the tensile bond strength between the relining material and the acrylic plate of the prosthesis. The tests were conducted taking into account 90-day term aging in the distilled water environment based on the methodology presented in the European Standard ISO 10139-2. (3) Results: After three months of observation, the highest strength of the joint was characterized by Flexacryl Soft acrylic, for which the average value was 2.5 MPa. The lowest average value of 0.89 MPa was recorded for the GC Reline Soft silicone material. Over time, an increase in the value of the strength of the combination of acrylic materials and a decrease in these values in the case of silicone materials was observed. (4) Conclusion: Each of the tested silicone materials showed all three types of damage, from adhesive to mixed to cohesive. All acrylic-based materials showed an adhesive type of failure. Time did not affect the type of destruction.
Volcanic Tuff as Secondary Raw Material in the Production of Clay Bricks
Authors: Cobîrzan Nicoleta , Thalmaier Gyorgy , Balog Anca-Andreea , Constantinescu Horia , Ceclan Andrei , Nasui Mircea
Published: November 2021

The present work examines an innovative manufacturing technique for fired clay bricks, using tuff as a secondary raw material. Samples were made of clay and tuff (0–30 wt.%) fired at 900 to 1100 °C. The chemical and mineralogical compositions and physical and thermal analyses of raw materials were investigated by using SEM-EDS, RX and DTA-TG curves. The samples were analysed from the mineralogical, technological and mechanical points of view. The result show that the tuff’s presence in the clay mixtures considerably reduced the shrinkage of the product during the firing process, and the manufactured samples were of excellent quality. The compressive strength of the bricks varied from 5–35.3MPa, being influenced by the tuff content, clay matrix properties and firing temperatures. Finally, the heat demand for increasing the temperature from room to the firing temperature of the sample with 10% tuff content was 22%.
Hybrid Materials Based on Fly Ash, Metakaolin, and Cement for 3D Printing
Authors: Marczyk Joanna , Ziejewska Celina , Gądek Szymon , Korniejenko Kinga , Łach Michał , Góra Mateusz , Kurek Izabela , Doğan-Sağlamtimur Neslihan , Hebda Marek , Szechyńska-Hebda Magdalena
Published: November 2021

Nowadays, one very dynamic development of 3D printing technology is required in the construction industry. However, the full implementation of this technology requires the optimization of the entire process, starting from the design of printing ideas, and ending with the development and implementation of new materials. The article presents, for the first time, the development of hybrid materials based on a geopolymer or ordinary Portland cement matrix that can be used for various 3D concrete-printing methods. Raw materials used in the research were defined by particle size distribution, specific surface area, morphology by scanning electron microscopy, X-ray diffraction, thermal analysis, radioactivity tests, X-ray fluorescence, Fourier transform infrared spectroscopy and leaching. The geopolymers, concrete, and hybrid samples were described according to compressive strength, flexural strength, and abrasion resistance. The study also evaluates the influence of the liquid-to-solid ratio on the properties of geopolymers, based on fly ash (FA) and metakaolin (MK). Printing tests of the analyzed mixtures were also carried out and their suitability for various applications related to 3D printing technology was assessed. Geopolymers and hybrids based on a geopolymer matrix with the addition of 5% cement resulted in the final materials behaving similarly to a non-Newtonian fluid. Without additional treatments, this type of material can be successfully used to fill the molds. The hybrid materials based on cement with a 5% addition of geopolymer, based on both FA and MK, enabled precise detail printing.
Electrochemical Mechanism of Recovery of Nickel Metal from Waste Lithium Ion Batteries by Molten Salt Electrolysis
Authors: Li Hui , Fu Yutian , Liang Jinglong , Li Chenxiao , Wang Jing , Yan Hongyan , Cai Zongying
Published: November 2021

With the widespread use of lithium-ion batteries, the cumulative amount of used lithium-ion batteries is also increasing year by year. Since waste lithium-ion batteries contain a large amount of valuable metals, the recovery of valuable metals has become one of the current research hotspots. The research uses electrometallurgical technology, and the main methods used are cyclic voltammetry, square wave voltammetry, chronoamperometry and open circuit potential. The electrochemical reduction behavior of Ni3+ in NaCl-CaCl2 molten salt was studied, and the electrochemical reduction behavior was further verified by using a Mo cavity electrode. It is determined that the reduction process of Ni3+ in LiNiO2 is mainly divided into two steps: LiNiO2 → NiO → Ni. Through the analysis of electrolysis products under different conditions, when the current value of LiNiO2 is not less than 0.03 A, the electrolysis product after 10 h is metallic Ni. When the current reaches 0.07 A, the current efficiency is 77.9%, while the Li+ in LiNiO2 is enriched in NaCl-CaCl2 molten salt. The method realizes the separation and extraction of the valuable metal Ni in the waste lithium-ion battery.
Biophysical Properties of Foamed and Solid Polymers Used in Orthotics and Prosthetics
Authors: Bohinc Klemen , Abram Anže , Zore Anamarija , Štukelj Roman , Lenarčič Ana , Vidrih Rajko , Škapin Andrijana Sever
Published: November 2021

Orthotic and prosthetic materials should have good mechanical and antibacterial properties. Therefore, in our study, we consider four common foamed closed-cells and two solid polymeric materials regarding their mechanical behaviour and tendency for bacterial adhesion. For all materials, the surface roughness, hydrophobicity, zeta potential, tensile properties, hardness and CIE color parameters were measured. We found that foamed polymeric materials have higher roughness, higher hydrophobicity, lower Young’s modulus, lower maximum tensile strength and lower hardness than solid materials. Bacterial adhesion test measurements based on observation by scanning electron microscopy show much a lower adhesion extent of S. aureus on solid materials than on foamed materials. The measured biophysical properties could be the key data for users to select the optimal materials.
Effect of Sc on the Hot Cracking Properties of 7xxx Aluminum Alloy and the Microstructure of Squeeze Castings
Authors: Xu Yongtao , Zhang Zhifeng , Gao Zhihua , Bai Yuelong , Zhao Purui , Mao Weimin
Published: November 2021

In this paper, the effect of adding the refiner Sc to the high Zn/Mg ratio 7xxx series aluminum alloy melt on the hot tearing performance, microstructure, and mechanical properties of the alloy is studied. The hot tearing performance test (CRC) method is used to evaluate the hot tearing performance of the alloy. The squeeze casting process was used to form solid cylindrical parts to analyze the structure and properties of the alloy. This study shows that the hot cracking sensitivity of the alloy after the addition of the refiner Sc is significantly reduced. The ingot grain size is significantly reduced, and the average grain size is reduced from about 86 μm to about 53 μm. While the mechanical properties are significantly improved, and the tensile strength reduced from 552 MPa is increased to 571 MPa, and the elongation rate is increased from 11% to 14%.
Role of Disordered Precursor in L10 Phase Formation in FePt-Based Nanocomposite Magnet
Authors: Crisan Alina Daniela , Dan Ioan , Crisan Ovidiu
Published: November 2021

In order to prove the usefulness of having a structurally disordered precursor to the formation of FePt L10 phase and to facilitate the co-existence of exchange coupled hard and soft magnetic phases with optimized magnetic properties in various conditions of annealing, a Fe-Pt-Zr-B melt spun alloy has been synthesized and detailed structural and magnetic investigations have been undertaken to probe its phase evolution during annealing. The dynamics of formation of the hard magnetic L10 phase during the gradual disorder–order phase transformation has been monitored by using a complex combination of X-ray diffraction methods and 57Fe Mössbauer spectroscopy methods, over a wide range of annealing temperatures. Multiple phases co-existing in the annealed sample microstructures, observed in XRD, have been reconfirmed by the Mössbauer spectra analysis and, moreover, accurate quantitative data have been acquired in what concerns the relative abundance of each of the observed crystalline phases in every stage of annealing. It is shown that the formation of the hard magnetic phase, emerging from the chemically disordered precursor, is gradual and occurs via complex mechanisms, involving the presence of a disordered Fe-Zr-B-rich intergranular region which contributes to an increase in the abundance of the L10 phase for higher annealing temperatures. Magnetic measurements have confirmed the good performances of these alloys in terms of coercivity and remanence. These results contribute to the development of these alloys as the next generation of rare earth, free permanent magnets.
Rare Orbital Metastasis Originating from Ampullary Adenocarcinoma
Authors: Tsai Yung-En , Chien Ke-Hung , Li Yao-Feng , Lai Shiue-Wei
Published: November 2021

Background: Orbital metastasis from ampullary carcinoma is rare, with no previously reported cases. Case presentation: We report the case of a 60-year-old man who complained of a right-sided headache, blurred vision, progressive proptosis, ptosis, and right eye pain for 3 months. His past medical history included an ampullary adenocarcinoma stage IIIA treated via the Whipple procedure and adjuvant chemoradiotherapy 1 year ago. However, he was lost to follow-up. Computed tomography of the orbit showed a soft tissue lesion in the right orbital fossa measuring 3.3 × 2 × 2 cm. An orbital mass biopsy demonstrated an intestinal-type adenocarcinoma that tested positive for cytokeratins 7 and 20 and CDX2 on immunohistochemical staining. The pathologic diagnosis was metastatic adenocarcinoma from the ampulla of Vater. Despite oncological treatment, the patient’s illness progressed. He received palliative treatment and died 1 month later. Conclusions: We presented a rare case of orbital metastasis from ampullary adenocarcinoma. This should be considered in the differential diagnosis of patients with a history of ampullary adenocarcinoma who present with symptoms referring to the relevant locations.
Influence of Preparation Temperature on the Properties and Performance of Composite PVDF-TiO2 Membranes
Authors: Tran Duc-Trung , Méricq Jean-Pierre , Mendret Julie , Brosillon Stephan , Faur Catherine
Published: November 2021

Composite PVDF-TiO2 membranes are studied extensively in literature as effective anti-fouling membranes with photocatalytic properties. Yet, a full understanding of how preparation parameters affect the final membrane structure, properties and performance has not been realized. In this study, PVDF-TiO2 membranes (20 wt% TiO2/PVDF) were fabricated via the non-solvent-induced phase separation (NIPS) method with an emphasis on the preparation temperature. Then, a systematic approach was employed to study the evolution of the membrane formation process and membrane properties when the preparation temperature changed, as well as to establish a link between them. Typical asymmetric membranes with a high porosity were obtained, along with a vast improvement in the permeate flux compared to the neat PVDF membranes, but a reduction in mechanical strength was also observed. Interestingly, upon the increase in preparation temperature, a significant transition in membrane morphology was observed, notably the gradual diminution of the finger-like macrovoids. Other membrane properties such as permeability, porosity, thermal and mechanical properties, and compression behavior were also influenced accordingly. Together, the establishment of the ternary phase diagrams, the study of solvent–nonsolvent exchange rate, and the direct microscopic observation of membrane formation during phase separation, helped explain such evolution in membrane properties.
Solidification Effect and Mechanism of Marine Muck Treated with Ionic Soil Stabilizer and Cement
Authors: Wu Xue-Ting , Qi Yi , Liu Jun-Ning , Chen Bin
Published: November 2021

In this study, an environmentally friendly ionic soil stabilizer (ISS) was adopted with combination of Portland cement to stabilize a marine muck. The macro and micro tests results demonstrated that the ISS was an effective stabilizer to improve the strength of marine muck when it was used combined with cement after adding the alkalizer NaOH. Except for the reduction in interlayer distance of clay minerals by ISS, Ca2+ and SO42− dissolved from ISS promoted the production of ettringite (AFt), pozzolanic and carbonation reactions of Portland cement in the presence of NaOH. Meanwhile, the hydration products of curing reaction notably agglomerated soil particles, which caused an obvious decrease of pores and a high increase of strength for solidified soils. Furthermore, this combination of stabilizers can not only save the dosage of cement, but also accelerate the solidification speed, decrease the cement setting time within 7 days to meet the curing requirements, and enhance the strength of solidified soils.
Anion Transport Using Core Functionalized Hyperbranched Polymers and Evidence of a Dense Packed Limit Based on Molecular Weight
Authors: Abdullah Sozan Najib , Mann Georgia , Twyman Lance J.
Published: November 2021

Being able to bind, select, and transport species is central to a number of fields, including medicine, materials, and environmental science. In particular, recognizing a specific species from one phase and transporting it across, or into another phase, has obvious applications in environ-mental science, for example, removal of unwanted or toxic materials from an aqueous or organic phase. In this paper, we describe an approach that uses a functionalized dendritic polymer to bind and transport a small anionic molecule across an organic phase (and between two aqueous phases). The design was based on encapsulation principles borrowed from nature, where anions are bound and transported by proteins that have specific sites within their globular ordered structures. For the work reported here, a globular dendritic polymer functionalized with an isophthalamide-based receptor was used to replace the protein structure and anion-binding site. Along with control experiments, the binding and transport properties of two functionalized HBPs were assessed using a Pressman U tube experiment. Both HBPs demonstrated an enhanced ability to bind and transport anions (when compared to the anion-binding site used in isolation). Furthermore, optimum binding and transport occurred when the smaller of the two HBPs were used. This supports our previous observations regarding the existence of a dense packed limit for HBPs.
The Effects of Streptozotocin-Induced Diabetes and Insulin Treatment on Carnitine Biosynthesis and Renal Excretion
Authors: Upadhyay Aman , Boyle Kate E. , Broderick Tom L.
Published: November 2021

Carnitine insufficiency is reported in type 1 diabetes mellitus. To determine whether this is accompanied by defects in biosynthesis and/or renal uptake, liver and kidney were obtained from male Sprague-Dawley rats with streptozotocin-induced diabetes. Diabetic rats exhibited the metabolic consequences of type 1 diabetes, including hypoinsulinemia, hyperglycemia, and increased urine output. Systemic hypocarnitinemia, expressed as free carnitine levels, was evident in the plasma, liver, and kidney of diabetic rats. Compared to control rats, the low free carnitine in the plasma of diabetic rats was accompanied by decreased expression of γ-butyrobetaine hydroxylase in liver and kidney, suggesting impaired carnitine biosynthesis. Expression of organic cation transporter-2 in kidney was also reduced, indicating impaired renal reabsorption, and confirmed by the presence of elevated levels of free carnitine in the urine of diabetic rats. Insulin treatment of diabetic rats reversed the plasma hypocarnitinemia, increased the free carnitine content in both kidney and liver, and prevented urinary losses of free carnitine. This was associated with increased expression of γ-butyrobetaine hydroxylase and organic cation transporter-2. The results of our study indicate that type 1 diabetes induced with streptozotocin disrupts carnitine biosynthesis and renal uptake mechanisms, leading to carnitine insufficiency. These aberrations in carnitine homeostasis are prevented with daily insulin treatment.