bluuebunny/crossref_metadata_2025 huggingface dataset:
PrivateGaze: Preserving User Privacy in Black-box Mobile Gaze Tracking Services
Authors: Du Lingyu , Jia Jinyuan , Zhang Xucong , Lan Guohao
Published: September 2024

Eye gaze contains rich information about human attention and cognitive processes. This capability makes the underlying technology, known as gaze tracking, a critical enabler for many ubiquitous applications and has triggered the development of easy-to-use gaze estimation services. Indeed, by utilizing the ubiquitous cameras on tablets and smartphones, users can readily access many gaze estimation services. In using these services, users must provide their full-face images to the gaze estimator, which is often a black box. This poses significant privacy threats to the users, especially when a malicious service provider gathers a large collection of face images to classify sensitive user attributes. In this work, we present PrivateGaze, the first approach that can effectively preserve users' privacy in black-box gaze tracking services without compromising gaze estimation performance. Specifically, we proposed a novel framework to train a privacy preserver that converts full-face images into obfuscated counterparts, which are effective for gaze estimation while containing no privacy information. Evaluation on four datasets shows that the obfuscated image can protect users' private information, such as identity and gender, against unauthorized attribute classification. Meanwhile, when used directly by the black-box gaze estimator as inputs, the obfuscated images lead to comparable tracking performance to the conventional, unprotected full-face images.
Plant Immunity Modulation in Arbuscular Mycorrhizal Symbiosis and Its Impact on Pathogens and Pests
Authors: Fiorilli V. , Martínez-Medina A. , Pozo Maria J. , Lanfranco L.
Published: September 2024

Arbuscular mycorrhizal (AM) symbiosis is the oldest and most widespread mutualistic association on Earth and involves plants and soil fungi belonging to Glomeromycotina. A complex molecular, cellular, and genetic developmental program enables partner recognition, fungal accommodation in plant tissues, and activation of symbiotic functions such as transfer of phosphorus in exchange for carbohydrates and lipids. AM fungi, as ancient obligate biotrophs, have evolved strategies to circumvent plant defense responses to guarantee an intimate and long-lasting mutualism. They are among those root-associated microorganisms able to boost plants’ ability to cope with biotic stresses leading to mycorrhiza-induced resistance (MIR), which can be effective across diverse hosts and against different attackers. Here, we examine the molecular mechanisms underlying the modulation of plant immunity during colonization by AM fungi and at the onset and display of MIR against belowground and aboveground pests and pathogens. Understanding the MIR efficiency spectrum and its regulation is of great importance to optimizing the biotechnological application of these beneficial microbes for sustainable crop protection.
Enhancing Microgrid Voltage and Frequency Stability through Multilayer Interactive Control Framework
Authors: Saadati Toularoud Moussa , Khoshhal Rudposhti Mohammad , Bagheri Sajad , Salemi Amir Hossein
Published: September 2024

Microgrids (MGs) play a crucial role in modern power distribution systems, particularly in ensuring reliable and efficient energy supply, integrating renewable energy sources, and enhancing grid resilience. Voltage and frequency stability are paramount for MG operation, necessitating advanced control frameworks to regulate key parameters effectively. This research introduces a multilayer interactive control framework tailored for MGs utilizing distributed energy resources (DERs). The framework comprises primary control layers, integrating internal voltage and current controller loops, and secondary layers employing distributed finite‐time control (DFTC) strategies. Through simulation studies and comparative analyses with traditional proportional‐integral (PI) controllers, the effectiveness of DFTC controllers in reducing initial oscillations and improving stability is demonstrated. Major findings include the superior performance of DFTC controllers in stabilizing voltage and frequency parameters, optimizing power output, and enhancing overall operational efficiency. Additionally, insights into the operational dynamics of MG systems highlight the significance of advanced control strategies in mitigating fluctuations and ensuring system stability. Furthermore, the proposed method demonstrates significant efficacy improvements over conventional approaches. Voltage stability is enhanced with oscillation amplitudes less than 0.01 pu, active power control achieves a stable level of 0.93 pu, and frequency fluctuations are reduced to 0.004 Hz and effectively recovered to 0.002 Hz. These improvements suggest that the proposed method enhances system stability and control precision by approximately 95% compared to conventional methods, as it achieves much tighter control over voltage, active power levels, and frequency fluctuations.
Shedding Light on Shadows: A Cross‐Sectional Analysis of Genital Psoriasis and Its Effects on Thai Individuals
Authors: Watchirakaeyoon Prameyuda , Kobkurkul Pantaree , Kulthanan Kanokvalai , Chaiyabutr Chayada , Wongpraparut Chanisada , Chularojanamontri Leena , Silpa-Archa Narumol
Published: September 2024

Background. Limited knowledge exists about genital psoriasis in Thai individuals. Objectives. This study aimed to assess the clinical features of genital psoriasis and its effects on quality of life and sexual health in Thai patients. Materials and Methods. A cross‐sectional, self‐administered question‐based study was conducted at Siriraj Hospital. Participants were psoriasis patients older than 18 years of age with past or current genital involvement. The study assessed quality of life and sexual health. Results. Among the 50 patients, 33 (66%) were female. The mean (standard deviation) age was 45.4 (±13.4) years. Genital psoriasis was active in 34% of the participants. The mons pubis (48.5%) and labia majora (18.2%) were the most frequently affected sites in females, while in males, the penile shaft (52.9%) and glans (47.1%) were the most common sites. Itch‐related symptoms predominated, affecting 82% of patients. The median dermatology life quality index score was 6.5 for females and 10 for males. A sexual health survey revealed that 54% of participants had low self‐esteem. This issue was more pronounced in males, with 76.5% reporting lower self‐esteem compared to 42.4% of females (P = 0.022). Males were also more inclined to postpone or avoid marriage (47.1% vs. 15.6%, P = 0.038) and more embarrassed about sexual activities (63.6% vs. 14.3%, P = 0.017). In addition, males were more inclined to avoid sexual encounters due to their genital condition. Notably, 42.9% of all patients had never disclosed to a doctor that they had genital psoriasis. Conclusions. Genital psoriasis impacts quality of life and sexual function, with male patients being particularly impacted. Improved awareness of these issues among health professionals might increase patient satisfaction.
Respectful Pruning Improves Grapevine Development: A Case Study in Young Vineyards
Authors: Galar-Martínez Mónica , Torres Nazareth , Sebastián Bárbara , Palacios Julián , Arzoz Ignacio , Juanena Nahiara , Villa-Llop Ana , Loidi Maite , Dewasme Coralie , Roby Jean Phillippe , Santesteban Luis Gonzaga
Published: September 2024

Grapevine pruning is an agronomical operation required to regulate growth and yield, improve fruit quality, and maintain plant health and vigour. However, the intensification of the crop in the last decades, driven by efforts to increase productivity and decrease costs, has led to reduced attention to this operation. The aim of this study was to investigate whether different pruning styles during the first years of vineyard training affect grapevine development. Three pruning styles were followed in a newly planted cv. “Tempranillo” vineyard for four consecutive pruning seasons: (i) respectful (RESP), where pruning cuts were always made leaving protection wood between the cut and vine perennial structures, and the preferential sap flow path was chosen; (ii) aggressive (AGGR), where no protection wood was left and, when possible, the nonpreferential sap flow path was followed; and (iii) winegrape grower (WIN), where the common practices used in the area were followed, which corresponds to an intermediate style between RESP and AGGR. In general, the RESP style increased the vegetative development compared to WIN and AGGR styles over the years and produced a higher yield in the first production year, although the intensity of the effect was not the same in the two vineyards considered. This was the first effort to systematically assess the effects of respectful pruning techniques on vine vegetative growth and demonstrate scientifically its impact.
Nasal Delivery of Asiatic Acid Ameliorates Scopolamine‐Induced Memory Dysfunction in Mice
Authors: Myint Su Lwin Lwin , Rodsiri Ratchanee , Benya-Aphikul Hattaya , Rojanaratha Tissana , Ritthidej Garnpimol , Islamie Ridho
Published: September 2024

Asiatic acid (AA) has previously shown its neuroprotective effects, but low oral bioavailability limits its penetration into the brain. This study aimed to investigate the effect of intranasal AA administration in mice with memory dysfunction induced by scopolamine. Mice received either intranasal AA (INAA), oral AA (POAA3 or POAA30), or donepezil, followed by scopolamine for 10 days. Morris water maze (MWM) was performed on days 0–5, 30 min after treatment. Locomotor activity was conducted on day 6 followed by brain collection. In MWM, INAA treatment had significantly reduced escape latency on days 2–4, while POAA3 decreased escape latency on day 3 and POAA30 and donepezil decreased escape latency on day 4. INAA inhibited acetylcholinesterase activity, increased catalase protein expression, and decreased malondialdehyde levels in the brain tissue. Therefore, intranasal administration of AA produced a rapid onset in the protection of learning and memory deficits induced by scopolamine through acetylcholinesterase inhibition and antioxidant effect.
Effects of Organic Substrate Amendments on Selected Organic Fractions and Biochemical Parameters under Different Soils
Authors: Giang Nguyen Do Chau , Dung Tran Van , Dong Nguyen Minh , Phuong Nguyen Minh , Long Vu Van
Published: September 2024

The application of organic substrates can affect soil respiration, dehydrogenase (DH‐ase) activity, dissolved organic carbon (DOC), and humic acid (HA) fractions. This study aimed to evaluate the effects of five organic substrates in the organic fractions of degraded alluvial soil, acid sulfate soil, and sandy soils and the physicochemical properties of the soil. Soil samples were amended at a rate of 5 tons ha−1 with (1) water hyacinth compost, (2) sugarcane filter cake compost, (3) biogas sludge‐rice straw compost, (4) vermicompost, and (5) sludge. The results showed that soil respiration and DH‐ase activity increased rapidly within the first 5 days of incubation, while the concentrations of DOC and HA decreased throughout the incubation period. The highest respiration and DH‐ase activity occurred after the application of vermicompost. DOC was found to be the highest in soils amended with sugarcane. The highest concentration of HA was observed with the application of sugarcane residues, regardless of the type of soil. The application of water hyacinth and biogas sludge stimulated cumulative HA only in the acid sulfate soil, while vermicompost improved HA only in the degraded soil. The largest stimulation in respiration and DH‐ase activity was observed in degraded and sandy soils, regardless of the type of amendment. In the acid sulfate soil (3.7 mg·C·g−1), larger amounts of DOC and HA were observed than in both degraded (1.7 mg·C·g−1) and sandy soils (1 mg·C·g−1). However, DH‐ase activity was the lowest in acid sulfate soil.
Figure 5 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Authors: Vorri Stamatia C. , Holl Natalie J. , Leeming Michael , Apostolova Petya , Marple Andrew , Ravich Jonas W. , Canbaz Ata , Rahnama Ruyan , Choe Jun , Modi Arjun , Fearnow Adam D. , Walsh Scott T.R. , Pearce Erika L. , Varadhan Ravi , Bonifant Challice L.
Published: September 2024

Hinge modifications do not improve antigen specificity of CD123-targeted chimeric IL7Rα. A, Amino acid sequences of hinge regions used in functional studies. B, Transduction efficiency measured using his-tagged rhCD123 binding of engineered receptors and flow cytometry. n = 3 unique T-cell donors. C, Quantification of phosphorylated STAT5 percentage in CCR-T cells measured with and without activation on the immobilized rhCD123 target. n = 3 unique T-cell donors, comparison between pSTAT5% in cytokine-starved cells with or without rhCD123 activation; *, P < 0.05. D, Representative Western blot testing IgG4 vs. IH STAT5 activation with and without immobilized rhCD123. NT, nontransduced.
Figure 4 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Authors: Vorri Stamatia C. , Holl Natalie J. , Leeming Michael , Apostolova Petya , Marple Andrew , Ravich Jonas W. , Canbaz Ata , Rahnama Ruyan , Choe Jun , Modi Arjun , Fearnow Adam D. , Walsh Scott T.R. , Pearce Erika L. , Varadhan Ravi , Bonifant Challice L.
Published: September 2024

CCR expression does not diminish CAR T-cell antitumor activity. A, Schematic of the xenograft model. On day 0, NSG mice were injected via tail vein with 1 × 106 CD123+ MV-4-11.ffLuc cells. In treatment groups, 2 × 106 T cells were administered on day 7. Cohorts: unmodified (NT), CD28.ζ CAR, and CD28.ζ CAR + IL7Rα CCR-T cells. B, Leukemia proliferation was monitored with BLI, and whole-animal radiance was recorded (photons/second/cm2/sr). Comparison of radiance in each group was performed following log transformation of each measured value. C, Kaplan–Meier survival analysis of MV-4-11 xenografts (n = 9 mice per condition; two independent experiments; median survival: NT: 45.5 days; CAR: 93.5 days; CAR + CCR: undefined; ***, P < 0.001; ****, P < 0.0001). NSG, NOD/SCIDγ; NT, nontransduced.
Efficacy and Safety of Telitacicept in IgA Nephropathy: A Retrospective, Multicenter Study
Authors: Liu Lijun , Liu Yimeng , Li Juan , Tang Chen , Wang Huiming , Chen Cheng , Long Haibo , Chen Xiaowen , Xing Guolan , Cheng Jingru , Liang Jianbo , Peng Xuan , Wang Liang , Shao Sijia , Lin Yongqiang , Chen Tianmu , Tang Ying , Shen Shizhong , Sun Lingyun , Wu Henglan , Yu Yuan , Du Xuanyi , Liu Hong , He Liyu , Liu Hong , Ye Meixing , Chen Wei , Wen Qiong , Zhang Hong , Cao Hongmin , Yuan Jing , Chen Hong , Wang Ming , Lv Jicheng , Zhang Hong
Published: September 2024

Introduction: The efficacy of telitacicept treatment in reducing proteinuria in patients with IgA nephropathy (IgAN) was indicated in a phase II clinical trial with small sample size. In this study, we conducted a large multicenter retrospective study to explore the efficacy and safety of telitacicept in patients with IgAN. Methods: This study recruited patients with IgAN from 19 sites from China who were treated with telitacicept and had been followed up at least once or with side effect reported, since April 1, 2021, to April 1, 2023. The primary outcomes of the study were the changing in proteinuria and eGFR over time. Results: A cohort of 97 patients with IgAN who were treated with telitacicept were recruited, with a median follow-up duration of 3 months. The median baseline proteinuria was 2.3 [1.3, 3.9] g/day and eGFR was 45.0 [26.8, 73.7] mL/min/1.73 m2. There was a significant reduction of proteinuria at 2, 4, 6 months when compared with baseline (2.3 [1.5, 4.1] vs. 1.5 [0.8, 2.3] g/day; 2.3 [1.1, 3.7] vs. 1.1 [0.6, 1.9] g/day; 2.1 [1.0, 2.7] vs. 0.9 [0.5, 1.7] g/day, all p values <0.01). The level of eGFR were comparable between at the baseline and 2, 4, 6 months of follow-up time (41.5 [29.7, 72.0] vs. 42.5 [28.8, 73.3] mL/min/1.73 m2; 41.0 [26.8, 67.7] vs. 44.7 [31.0, 67.8] mL/min/1.73 m2; 33.7 [24.0, 58.5] vs. 32.6 [27.8, 57.5] mL/min/1.73 m2, all p values >0.26). Telitacicept was well tolerated in the patients. Conclusions: This study indicates that telitacicept alone or on top of steroids therapy can significantly and safely reduce proteinuria in patients with IgAN. The long-term kidney protection still needs to be confirmed in large phase III trial.
Neonatal Hydrocolpos in Bardet-Biedl Syndrome due to a Novel Frameshift Indel in the BBS10 Gene
Authors: Palma Sircili Maria Helena , Batista Rafael Loch , Barreto Enoch Quindere de Sá , Bueno Solange Paiva , Figueredo Benedetti Anna Flávia , Craveiro Flora Ladeira , Ramos Raquel Matinez , Monteiro Filho Marcelo Praxedes , Domenice Sorahia , Mendonca Berenice Bilharinho , Dénes Francisco Tibor
Published: September 2024

Introduction: Hydrocolpos, a rare condition characterized by cystic dilatation of the vagina, can arise from various etiologies, including isolated imperforate hymen and vaginal atresia. Genetic conditions, such as Bardet-Biedl syndrome (BBS), may also manifest with hydrocolpos as part of urogenital malformations. Methods: We present a case of neonatal hydrocolpos associated with BBS. Sequencing of 19 BBS genes was performed to elucidate the genetic basis of the syndrome. Results: Genetic analysis revealed a novel frameshift indel variant (c.1543_1546dup p.Thr516Argfs*7) in the BBS10 gene. This finding expands the spectrum of BBS mutations and underscores the importance of genetic evaluation in patients with hydrocolpos, particularly when associated with additional clinical features suggestive of syndromic etiology. Conclusion: Pediatric urologists should maintain a high index of suspicion for underlying genetic conditions, including BBS, in neonates presenting with hydrocolpos, given the potential for more severe associated complications such as renal and retinal diseases, obesity, and polydactyly.
High Resting Heart Rate Is Associated with Cardiovascular Death in Patients with Stroke, Independent of Sex
Authors: Heuer Christine , Gebhard Catherine , Shuaib Ashfaq , Held Ulrike , Wegener Susanne ,   On behalf of the VISTA collaborators
Published: September 2024

Introduction: High resting heart rate (HRHR) is a surrogate marker of increased sympathetic outflow. In acute stroke patients, HRHR is more commonly observed in women than in men. We analyzed whether HRHR (>86 bpm) adds incremental prognostic value for stroke outcomes in women. Methods: We analyzed data of 6,024 patients (2,568 women, mean age 68.98 years) with acute ischemic stroke from the Virtual International Stroke Trials Archive (VISTA). Results: Patients with HRHR were more often female (45.3 vs. 41.8%, p = 0.017), younger (66.0 ± 13.2 vs. 67.8 ± 12.6 years, p < 0.001), had higher baseline systolic blood pressure and more often diabetes. The primary composite endpoint of recurrent ischemic stroke, transient ischemic attack, myocardial infarction, or cardiovascular death within 90 days occurred more often in patients with HRHR (19.3 vs. 14.6%, p < 0.001). HRHR was associated with worse functional outcome at 90 days as assessed by modified Rankin Scale (mRS90: 3.03 ± 1.98 vs. 2.82 ± 1.94, p = 0.001). As exclusion of deceased patients (mRS90 of 6) resulted in a loss of association of HRHR with mRS90, it can be assumed that HRHR is mainly associated with poststroke vascular mortality, but not disability. Female sex was not associated with the primary endpoint but with adverse functional outcome measured by mRS90. Conclusion: HRHR was associated with adverse events and mortality after stroke. Despite a higher prevalence of HRHR in women, they did not reach the primary endpoint more often. However, women had a worse functional outcome (mRS) 3 months after stroke, independent of HRHR.
Acute Renal Infarction: A 12-Year Retrospective Analysis
Authors: Greenberg Sheldon , Jana Kundan , Janga Kalyana , Lee Meng-Hsun , Lockwood Mary
Published: September 2024

Introduction: Acute renal infarction (ARI) is a relatively rare and underdiagnosed condition. Presenting symptoms are nonspecific, and imaging is the mainstay for diagnosis. This study attempts to characterize the profile of patients with ARI and identify possible risk factors. Methods: All inpatients admitted with diagnosis of ARI between 2010 and 2022 were included in this single-center retrospective observational study. Patients with chronic renal infarction, iatrogenic causes, and without radiographic evidence of ARI were excluded. Clinical, laboratory, and radiological findings of patients were collected. Patients were grouped into three groups based on probable etiology: cardiovascular, hypercoagulable disorders, and idiopathic, and analyzed. Results: Eighty-five patients were included. Mean age of patients was 61.6 ± 17.54 years. Cardiovascular group had the highest number of patients (49.4%) of which atrial fibrillation was the most common etiology (59.5%). Malignancy was the most common etiology in the hypercoagulable disorder group (69.3%). Patients in the idiopathic group were significantly younger and had higher mean body mass index than the other 2 groups at presentation. Smokers had 9 times higher risk of renal infarction in cardiovascular group and 1.7 times higher risk in hypercoagulable when compared to the idiopathic group. 48.2% of patients developed renal infarction though they were on antiplatelets/anticoagulants. Conclusion: ARI is a rare and often underdiagnosed condition that can have residual renal dysfunction. It is important to consider ARI as a differential especially in young patients with risk factors even if they are on anticoagulation medication.
A Scoping Review of Population Diversity in the Common Genomic Aberrations of Clear Cell Renal Cell Carcinoma
Authors: Kumar Sean S. , Khandekar Ninad , Dani Komal , Bhatt Saina R. , Duddalwar Vinay , D’Souza Anishka
Published: September 2024

Introduction: Previous literature has shown that clear cell renal cell carcinoma (ccRCC) is becoming a more prevalent diagnosis and that the incidence and mortality differ both regionally and racially. While the molecular profiles for ccRCC are studied regionally through biopsy and sequencing techniques, the genomic landscape and ccRCC diversity data are not well studied. We conducted a review of the known genomic data on 6 of the most clinically relevant DNA biomarkers in ccRCC: von Hippel-Lindau (vHL), Polybromo‐1 (PBRM1), Breast Cancer Gene 1‐Associated Protein 1 (BAP1), Histone-Lysine N‐Methyltransferase Domain‐Containing 2 (SETD2), Mammalian Target of Rapamycin (mTOR), and Lysine‐Specific Demethylase 5C (KDM5C). The review compiled genomic diversity data, incidence, and risk factor differences by geographical and racial cohorts. Methods: The review methodology was created using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) principles from articles on PubMed and Embase through July 31, 2023, written and published in English, with diagnoses of primary or metastatic ccRCC via cytology or pathology, recorded the incidence of one or more of the 6 biomarkers, explored gene aberration via sequencing, were epidemiological in nature, and/or discussed basic science research, cohort studies, or retrospective studies. Results: Aberrations in vHL, PBRM1, and SETD2 driving ccRCC are studied frequently, but the data are heterogeneous, whereas there is a paucity in the data regarding KDM5C, PBRM1, and mTOR mutations. Conclusion: Studying the genetic aberrations that frequently occur in different regions gives insight into what current research lacks. When more genomic landscape research arises, precision therapy, risk calculators, and artificial intelligence may help better prognosticate and individualize treatment for those at risk for ccRCC. Provided the scarcity of existing data, and the rising prevalence of ccRCC, more studies must be conducted at the clinical level.
O Ensino do Contrabaixo Elétrico por Meio de Aulas Centradas na Pessoa: uma Pesquisa Ação com Estudantes
Authors: Medeiros Jhoninha , Marins Paulo , Oliveira Livia Roberta
Published: September 2024

TEACHING ELECTRIC BASS THROUGH STUDENT CENTERED CLASSES: AN ACTION RESEARCH WITH STUDENTS OF THE UNDERGRADUATE DEGREE PROGRAM IN MUSIC EDUCATION OF UNIVERSITY OF BRASÍLIA
Targeting Fibrinolytic Inhibition for Venous Thromboembolism Treatment: Overview of an Emerging Therapeutic Approach
Authors: Singh Satish , Kumar Pardeep , Padwad Yogendra S. , Jaffer Farouc A. , Reed Guy L.
Published: September 2024

Venous thrombosis and pulmonary embolism (venous thromboembolism) are important causes of morbidity and mortality worldwide. In patients with venous thromboembolism, thrombi obstruct blood vessels and resist physiological dissolution (fibrinolysis), which can be life threatening and cause chronic complications. Plasminogen activator therapy, which was developed >50 years ago, is effective in dissolving thrombi but has unacceptable bleeding risks. Safe dissolution of thrombi in patients with venous thromboembolism has been elusive despite multiple innovations in plasminogen activator design and catheter-based therapy. Evidence now suggests that fibrinolysis is rigidly controlled by endogenous fibrinolysis inhibitors, including α2-antiplasmin, plasminogen activator inhibitor-1, and thrombin-activable fibrinolysis inhibitor. Elevated levels of these fibrinolysis inhibitors are associated with an increased risk of venous thromboembolism in humans. New therapeutic paradigms suggest that accelerated and effective fibrinolysis may be achieved safely by therapeutically targeting these fibrinolytic inhibitors in venous thromboembolism. In this article, we discuss the role of fibrinolytic components in venous thromboembolism and the current status of research and development targeting fibrinolysis inhibitors.
Vincetoxicum bungei (Apocynaceae), a new combination for a common medicinal species from East Asia
Authors: ZHANG CAI-FEI , HU GUANG-WAN
Published: September 2024

N/A
New Ceratorchestes (Acari, Oribatida, Peloppiidae) from Venezuela
Authors: ERMILOV SERGEY G.
Published: September 2024

Three new species of Ceratorchestes (Ceratorchestes) (Oribatida, Peloppiidae)—C. (C.) tripartitus sp. nov., C. (C.) duocornutus sp. nov. and C. (C.) truncatus sp. nov.—are described, based on adults collected from leaf litter in northern Venezuela. Ceratorchestes (Paraceratorchestes) melzeri is recorded for the first time from Venezuela. An identification key, distribution and habitat to the known species of Ceratorchestes are provided.
The first record of the alpheid shrimp Automate isabelae Ramos-Tafur, 2018 from Brazil (Decapoda: Caridea)
Authors: ANKER ARTHUR , TAVARES MARCOS
Published: September 2024

The alpheid shrimp Automate isabelae Ramos-Tafur, 2018 was described based on material found in stomachs of the lane snapper Lutjanus synagris (L.) in the Florida Keys and south-western coast of Florida, USA (24°N). In the present study, A. isabelae is reported from Araçá Bay, São Sebastião, São Paulo, Brazil (23°S), the first time since its original description, representing the first record of the species for the south-western Atlantic. The colour pattern of A. isabelae is illustrated for the first time. The differentiating characters between A. isabelae and its presumed eastern Pacific sister species A. rugosa Coutière, 1902 are discussed.
Is Pope Francis’s Social Teaching Post-Cardijn?
Authors: Cornish Sandie
Published: September 2024

Pope Francis’s two social encyclicals and his addresses to Cardijn movements reveal that he reinterprets and goes beyond the see-judge-act method. The pastoral spiral and the Ignatian pedagogical paradigm better describe the dynamics of his social teaching. Furthermore, reading Francis solely through a see-judge-act lens obscures important aspects of his teaching. Elements of his post-Cardijn approach include: a wholistic and inclusive approach to experience; respect for the agency of all; seeking understanding through encounter, listening and dialogue; flexible and open-ended processes; the integration of spirituality at every stage; and the use of new language that communicates effectively with contemporary pluralist societies.
How was your Crossing Experience? Development of a Pedestrian Satisfaction with Unsignalized Crossings Scale
Authors: LaJeunesse Seth , Kumfer Wesley , Kothuri Sirisha , Nordback Krista , McNeil Nathan
Published: September 2024

Unsignalized pedestrian crossing accommodations can improve pedestrian safety, yet their quality of service for pedestrians remains understudied. The present study explored whether and how pedestrians’ satisfaction with crossing unsignalized crossings varied according to the type of crossing accommodation used, that is, the rectangular rapid-flashing beacon (RRFB) with median island, median island alone, marked crosswalk, and unmarked crosswalk. The research team collected intercept survey and video observation data from 358 pedestrians across a total of 40 sites in two different cities. Structural equation models illustrated how pedestrians’ crossing-oriented satisfaction was shaped by their positive perceptions of safety and low levels of delay in the act of crossing the street. Crossing satisfaction also varied by unsignalized crossing accommodation type. Pedestrians perceived RRFBs with medians and median islands by themselves as comparably safer, more time efficient, and thus more satisfying than marked crosswalks without RRFBs or raised medians or at unmarked crosswalks. These findings could inform efforts to provide higher quality of service to pedestrians.
From a Spoke to a Hub: The Case of South Korea
Authors: Lee Woocheol
Published: September 2024

A few East Asian newly industrialized countries that used to belong to the Global South not only have joined the Global North but also have organized their own production chains in specific industries. Given the imperialist and exploitative nature of global production chains established by the Global North, it should be questioned whether the production chains organized by the East Asian newly industrialized countries are free from the innate nature of production chains. This article adopts a multiregional input-output analysis to examine the bilateral trade relationship between Korea and Vietnam. It finds that the Korean economy has unequally captured the benefits from the bilateral trade with Vietnam in terms of the domestic value-added share and the spillover effect derived from the final demand for Vietnamese products in the textile and electronics industries.

JEL Classification: F62, F63
Reporting Hormone Receptor Expression in Breast Carcinomas: Which Method has the Highest Prognostic Power and What Should be the Optimal Cut-off Value?
Authors: Öztürk Çiğdem , Okcu Oğuzhan , Öztürk Seda Duman , Şen Bayram , Öztürk Ahmet Emin , Bedir Recep
Published: September 2024

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Hormone receptor (HR) expression is a critical marker that plays a role in the treatment and management of breast cancer. Even if patients receive hormone treatment with a hormone positivity rate of over 1%, it is controversial at what level of positivity they benefit from treatment and contribute positively to their prognosis.

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We retrospectively examined the estrogen receptor (ER) / progesterone receptor (PR) expression status, clinicopathological findings, and survival data of 386 patients who underwent surgery for breast cancer. ER/PR expressions of the patients were evaluated according to Allred, H-score and were also grouped according to staining percentages. Separate cut-off values were determined for each of these evaluation methods, and the prognostic power of these methods was investigated using receiver operating characteristic analysis.

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The prognostic power of all methods was found to be similar in terms of predicting survival. According to the staining percentage of the patients, survival was excellent if the ER value was >80% and the PR value was >1%.

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All recommended methods for reporting HRs have similar prognostic power. However, in patients with high percentage staining for ER using these methods, the prognosis is excellent. As a result, we predict that if the percentage of ER staining is low, changing the treatment management of patients may be considered clinically.
The Effects of Self Monitoring With I-Connect to Increase On Task Behavior of Students With or at Risk for Emotional and Behavioral Disorders
Authors: Del Vecchio Marissa L. , Crosland Kimberly , Fuller Asha
Published: September 2024

The use of technology-based self monitoring (SM) interventions is becoming more popular, increasing the likelihood that SM interventions will have greater contextual fit within classrooms. SM has resulted in increases in desired school behaviors, such as increases in on task behavior, academic performance, and task completion for students diagnosed with disabilities. The purpose of this study was to extend the findings from Clemons et al. and examine student and teacher use of a web based SM application, I-Connect, and reinforcement to increase on task behavior for three U.S. elementary school students with or at risk for an emotional behavioral disorder using extended SM intervals. All three participants demonstrated significant increases in on task behavior with the use of the I-Connect application plus reinforcement intervention in the classroom.
Global buckling response of sandwich panels with additively manufactured lattice cores
Authors: Osmanoglu Serhat , Mittelstedt Christian
Published: September 2024

This paper deals with the analytical and numerical global buckling analysis of rectangular sandwich plates utilized AlSi10 Mg in both facesheets and lattice cores. In this study, six different strut-based lattice core models are designed. Additionally, the buckling resistance of lattice panels is compared with a typical honeycomb panel. Analytical studies were carried out using Kirchoff plate theory (CLPT), first-order shear deformation theory (FSDT) coded on MATLAB and finite element (FE) analyses in Abaqus. In the theoretical approaches, the Navier solution is derived for sandwich plates with simply supported boundary conditions at all edges. In the FE analyses, validated homogenized lattice structures models were used to avoid excessive numbers of elements and to save computational time. The parametric effects of side-to-thickness ratio, and different designed core cells on global buckling responses are investigated. As a result of comparing the analytical results with the FE model, a good agreement is obtained, and it is found that analytical buckling analyses FSDT can be used within certain size limits for the global buckling analysis of lattice core sandwich structures.
Relapsing tumefactive demyelination lesions: A unique, distinct inflammatory brain pathology
Authors: Perini Paola , Gaggiola Marta , Rinaldi Francesca , Gallo Paolo , Puthenparampil Marco
Published: September 2024

We report the case of a patient suffering from biopsy-proven relapsing tumefactive demyelinating lesions (TDLs) of the central nervous system who had five relapses in 16 years. No signs/symptoms suggestive of alternative pathologies emerged during the follow-up. A limited benefit was observed with intravenous (IV) high-dose steroids, while both plasma exchange and IV immunoglobulin G (IgG) administration were ineffective. A long-lasting (9 years) but transient clinical stabilization was obtained with cyclophosphamide. Our case supports the view that recurrent TDL is a relapsing brain inflammation not belonging to multiple sclerosis (MS) or myelin oligodendrocyte glycoprotein (MOG)-/AQP4-associated disorders. TDL concept and clinical features should be revised.
Solitary medial proximal tibial osteochondromas cause pes anserinus syndrome in adolescents
Authors: Saglam Fevzi , Serttas Muhammed Fatih
Published: September 2024

Objective:

Osteochondromas are common bone tumors with hyaline cartilage-covered heads, arising from cortical and medullary bone. Solitary medial proximal tibial osteochondromas (MPTOs) can cause pes anserinus syndrome via compression. However, the literature lacks comprehensive studies on MPTO-related pes anserinus syndrome and its surgical outcomes.

Material and Method:

The study reviewed 227 patients diagnosed with osteochondroma between January 2018 and January 2022, with 21 patients meeting inclusion criteria: under 19 years, MPTO, surgical excision, histological diagnosis, ≥1-year follow-up. Cases with irregular follow-ups and multiple hereditary exostoses were excluded. Different surgical techniques were employed based on lesion characteristics. Postoperative weight bearing was allowed, and follow-ups involved postoperative complications assessment, clinical data collection, imaging, and functional evaluations using the International Knee Documentation Committee (IKDC) and Hospital for Special Surgery Pediatric Functional Activity Brief Scale scoring systems.

Results:

The study involved 21 adolescents (15 ± 2 years). Lesion types were predominantly pedunculated (86%) and surgical interventions involved pes anserinus split (76%) or tenoplasty (24%). No significant correlations were observed between lesion dimensions and IKDC scores. Split intervention led to a significant improvement in IKDC scores ( p < 0.01), while tenoplasty showed similar results ( p < 0.05). Athlete status did not affect IKDC scores significantly, but both athletes and non-athletes demonstrated improvements ( p < 0.05).

Conclusion:

The negative impact of MPTOs causing pes anserinus tendinitis on the patient’s quality of life and activity can be completely corrected with surgical treatment. Complete pes anserinus tendon cutting and subsequent repair are recommended if they facilitate surgery. The study underscores the importance of surgical management for MPTO-related pes anserinus syndrome and provides insights into the effectiveness of different surgical techniques.
‘Soft Rebellion’: Flow art, critical play, and wellbeing in the city
Authors: Mulari Heta , Hartman Maaria
Published: September 2024

This article discusses the intersections between flow art, critical play, and wellbeing in urban contexts in Finland. Flow art as an art form sits at the intersection of several movement-based creative disciplines, including contemporary circus, dance, and the underground electronic music scene. It is based on DIY in terms of making one's own props and choreographies and peer teaching/learning. The flow artists make use of several props familiar to the circus arts, including contact sticks, poi, hula hoops, diabolos, dragon staffs, and fans. The article explores how urban artistic take-overs can be understood as critical play, including the potential for political subversion and changing the meanings of urban spaces. Further, the article discusses how wellbeing is understood holistically, relationally, and interconnected to the concept of flow. The article is a result of ethnographic research conducted with flow art communities in 2021–2023.
A multicenter phase 2 clinical trial of low-dose subcutaneous decitabine in myelofibrosis
Authors: Lin Chenyu , Patel Anand A. , Huo Dezheng , Karrison Theodore , van Besien Koen , Godwin John , Sher Dorie , Weiner Howie , Green Margaret , Wade James L. , Klisovic Rebecca , Baer Maria R. , Larson Richard A. , Stock Wendy , Odenike Olatoyosi
Published: September 2024

Myelofibrosis (MF) in the chronic phase is a challenging disease to treat, and conventional treatment options are geared toward symptom palliation. In this prospective, multicenter, phase 2 trial, 21 patients with MF (18 chronic phase, 2 accelerated phase, and 1 blast phase) were treated with a 10-day schedule of subcutaneous decitabine at 0.3 mg/kg per day. The overall response rate was 33% (95% confidence interval, 15-57), primarily manifested as an improvement in cytopenias. The median duration of response was 7 months (range, 3-44). A high International Prognostic Scoring System risk score, high baseline fetal hemoglobin level, and sustained decrease in circulating CD34+ cell counts were associated with response to decitabine. All patients experienced at least 1 grade 3/4 cytopenia. Nonhematologic toxicities were less frequent, with fatigue, anorexia, and hypocalcemia being the most common. Given the lack of effective therapies in MF with severe cytopenias, this study supports further investigation into the use of hypomethylating agents as single agents or in combination therapies. This trial was registered at www.ClinicalTrials.gov as #NCT00095784.
Persistent post-flood hillslope activity posing a potential landslide dam hazard in the Ahr valley, Germany
Authors: Wenzel Till , Bell Rainer , Dietze Michael , Schrott Lothar
Published: September 2024

Background

Extreme floods are known to severely reorganise inhabited landscapes by inundation, clogging, scouring and damaging infrastructure and lives. However, their post-event impacts are poorly understood, especially concerning coupled hillslope channel feedbacks such as the reactivation of slope instabilities connected to the river and that may be able to block it upon sudden failure. The July 2021 Ahr valley flood exemplified this ability of concurrent and sustained landscape reorganisation. Here, we study a retrogressive slope instability near the town of Müsch, in the upper Ahr valley using field mapping, repeat airborne laser scanning, electrical resistivity tomography and passive seismic monitoring to reveal the failure geometry, its mechanisms and transient activity.

Results

The old landslide developed in lower Devonian rocks. It is 100 m wide, 200 m long and approximately 15–20 m deep, which leads to a total volume of about 430,000 m3. This landslide was severely undercut by the 2021 flood with 7000 m3 of material eroded at the landslide toe. The landslide has started to react. Given the narrow section of the river at this location, there is a potential landslide dam hazard. We modelled the inundation volumes and back fill times for different failure scenarios, ranging between 20,000 m3 and 330,000 m3 accumulating within 5 min and 20 h.

Conclusions

Our results imply a need to systematically screen flood impacted landscapes for sustained post-event hillslope activity that governs hillslope-channel coupling, driving both persistent sediment injection into the stream and sudden river blocking and subsequent damming.
Subclinical atherosclerosis burden in carotid and femoral territories in HIV subjects: relationships with HIV and non-HIV related factors
Authors: Ferrer Pedro , López Laura , Pérez Juncal , Cabello Noemi , Núñez María José , Sagastagoitia Iñigo , Cotarelo Manuel , de Isla Leopoldo Pérez , Estrada Vicente
Published: September 2024

Background

Cardiovascular disease is a major cause of morbidity in an aging HIV population. However, risk estimation with the most frequent equations usually classifies HIV patients as having a low or moderate risk. Several studies have described a very high prevalence of subclinical atherosclerosis in a middle-aged, non-HIV population. There is insufficient body of knowledge to understand if this is the case in people living with HIV (PLWH). We aim to calculate the proportion of patients with subclinical atherosclerosis in a single site cohort of HIV-infected subjects.

Methods

We have analyzed chronically HIV infected adults (≥ 18 years) who were on active follow-up in an HIV unit specialized in the care of cardiovascular health. The most recent clinical visit and vascular ultrasonography were used to assess the objectives of our research. Our primary objective was to describe the proportion of participants with subclinical atherosclerosis (focal protrusion into the lumen > 0.5 mm or > 50% of the surrounding IMT or a diffuse thickness > 1.5 mm) in a single site cohort of PLWH. Carotid and iliofemoral territories were evaluated. As a secondary objective we have run a multivariate analysis to determine which HIV and non-HIV factors might be related with the presence of atherosclerotic plaques.

Findings

We included a total of 463 participants between November 2017 to October 2019. Subjects were predominantly male (84.2%) with a mean age of 48.8 years (SD 10.7). Hypercholesterolemia (36%) was the most prevalent comorbidity followed by Hypertension (18%) and Hypertriglyceridemia (16%). Mean duration of HIV infection is 12.3 years. Overall, participants had been receiving cART for a median of 9.5 years. Subclinical atherosclerosis was found in 197 subjects (42.5%; CI 95% [38.0–47.2]). The disease was found more frequently in the femoral arteries (37.8%) than in the carotid vascular bed (18.6%). Despite some HIV factors correlated with the presence of plaques in a univariate analysis (e.g., time with HIV-1 RNA > 50 copies/mL or time from HIV diagnosis), the only two explanatory factors that remained associated with the presence of atherosclerotic plaques in the multivariate analysis were smoking (OR 5.47, 95% CI 3.36 – 8.90) and age (OR 1.13, 95%CI 1.10 – 1.16).

Interpretation

We have found a very high prevalence of subclinical atherosclerosis among our cohort of PLWH. Despite having analyzed several HIV factors, age and smoking have been found to be the only factors associated with the development of atherosclerotic plaques.
High-risk factors for massive haemorrhage in medical abortion patients with missed miscarriage
Authors: Tan Yuru , Li Sen , Xu Hong , Wang Shuying
Published: September 2024

Background

Recently, the incidence of missed miscarriage has gradually increased, and medical abortion is a common method to terminate a pregnancy. In the process of medical abortion, massive vaginal bleeding takes place, leading to emergency surgical haemostasis. Emergency surgery may produce infection and organ damage. Our study aimed to investigate the high-risk factors for massive haemorrhage during a medical abortion.

Methods

A total of 1062 missed miscarriage patients who underwent medical abortion participated in this retrospective study. According to the amount of bleeding, the patients were divided into a massive haemorrhage group and a control group. By comparing the general conditions of the two groups, such as fertility history, uterine surgery history, uterine fibroids, etc., the high-risk factors for massive haemorrhage during medical abortion were identified.

Results

Relative to the control group, the massive haemorrhage group exhibited a higher proportion of patients with a previous artificial abortion (51.9% vs. 38.1%, P = 0.001). Additionally, the massive haemorrhage group had a lower percentage of first-time pregnant women (32.1% vs. 40.4%) and a higher proportion of women with shorter pregnancy intervals (44.9% vs. 33.1%, P = 0.03). Furthermore, there were notable differences between the two groups regarding maximum fibroid size, the duration of amenorrhea, and gestational week (P < 0.05).

Conclusion

In this study, we determined that a history of artificial abortion and an amenorrhea duration of > 11 weeks represented high-risk factors for massive vaginal bleeding during medical abortion in missed miscarriage patients.