bluuebunny/crossref_metadata_2025 huggingface dataset:
Abstract PO5-27-10: Next generation antibody drug conjugates: Multi-payload conjugates targeting multiple mechanisms of cell killing
Authors: Lobba Marco , Trinter Devin , Nguyen Maxwell , Gutierrez Daniel , Brady Samantha , Symister Chanez , Lau Andrew , Kendall Richard , Johri Saurabh , Francis Matthew
Published: May 2024

Background: ADCs have had tremendous impact on patient outcomes in breast cancer and are rapidly moving towards second line use. However, many patients fail to respond or relapse after treatment with ADC therapies due to tumor heterogeneity and resistance to ADC payloads. Method: CatenaBio has developed a novel Multi-Payload-Conjugate (MPC) system capable of attaching distinct payloads at different sites to the same antibody, enabling the production of single-molecule targeted combination therapies with defined DAR. Results: We screened combinations of different payloads targeting several different mechanisms attached to trastuzumab at different drug-antibody ratios to optimize tumor cell killing. These targeted combination ADCs demonstrated robust killing in both HER2 high and low tumor cell lines. Conclusion: Antibody Drug Conjugates have revolutionized the treatment of high HER2 positive breast cancer. More recently advances have been made in the design of ADCs to expand indications to include HER2 low as well as HER2 negative patients. These constructs offer the next step in ADC design and allow for the combination of multiple mechanisms of action in a single MPC that are highly effective across multiple breast cancer cell lines. These molecules offer the potential to circumvent tumor resistance pathways and deliver deeper and more durable responses. Disclosures: Marco Lobba, Devin Trinter, Maxwell Nguyen, Daniel Gutierrez, Samantha Brady, Chanez Symister, Andrew Lau, Richard Kendall, and Saurabh Johri are employed by Catena Biosciences. Matthew Francis is a co-founder and advisor to Catena Biosciences.

Citation Format: Marco Lobba, Devin Trinter, Maxwell Nguyen, Daniel Gutierrez, Samantha Brady, Chanez Symister, Andrew Lau, Richard Kendall, Saurabh Johri, Matthew Francis. Next generation antibody drug conjugates: Multi-payload conjugates targeting multiple mechanisms of cell killing [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO5-27-10.
Abstract PO5-27-11: A COMPARATIVE STUDY OF DIAGNOSTICS MADE BY FINE NEEDLE ASPIRATION (FNA) BIOPSY VERSUS TRU-CUT FOR BREAST PATHOLOGY IN A ONE STOP CLINIC PROGRAM IN MEDELLIN, COLOMBIA
Authors: Gil Sara , Agudelo Carlos , Castaño Jorge , Naranjo Melissa , Piedrahita Clara , Wilches Daniel , Corredor Kelly
Published: May 2024

Breast cancer is the leading cause of morbidity and mortality among women in Colombia due to non-communicable chronic diseases. This has prompted health insurance companies to develop innovative initiatives to mitigate these negative outcomes. Since September 2018, Ayudas Diagnósticas SURA, in alliance with the Gustave Roussy Hospital and General Electric Healthcare has promoted a “One-stop clinic” program called: “TIEMPO PARA TI”. One of the primary challenges was to demonstrate that breast cytology, based on the Yokohama guidelines approved by The International Academy of Cytology has a high sensitivity, specificity, and diagnostic accuracy. The Yokohama system for classifying breast cytology is comprised of five categories: C1 not satisfactory, C2 benign, C3 atypical, C4 malignancy suspected, and C5 malignant. From September 2018 to December 2022, consecutive patients referred for breast biopsy and suspected of having breast cancer underwent triple assessment of breast tumor and were included in this retrospective study. Descriptive analysis was made using STATA v17 software to compare fine needle aspiration (FNA) biopsy versus Tru-cut. A total of 14,501 patients were included, 14.398 FNA and 14.401 trucut biopsies were performed. The comparative analysis showed a 99% concordance between categories 2, which correspond to benign lesions and 96.7% between categories 5, which correspond to malignant lesions. Our findings demonstrate that a well-executed FNA biopsy is not inferior to a trucut biopsy, as revealed by the Yokohama system, and offers significant advantages, such as cost-effectiveness and prompt diagnosis. Both techniques should be used with caution, considering their advantages and disadvantages.

Citation Format: Sara Gil, Carlos Agudelo, Jorge Castaño, Melissa Naranjo, Clara Piedrahita, Daniel Wilches, Kelly Corredor. A COMPARATIVE STUDY OF DIAGNOSTICS MADE BY FINE NEEDLE ASPIRATION (FNA) BIOPSY VERSUS TRU-CUT FOR BREAST PATHOLOGY IN A ONE STOP CLINIC PROGRAM IN MEDELLIN, COLOMBIA [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO5-27-11.
Supplementary Figure 5 from ROR2/Wnt5a Signaling Regulates Directional Cell Migration and Early Tumor Cell Invasion in Ovarian Cancer
Authors: Grither Whitney R. , Baker Breanna , Morikis Vasilios A. , Ilagan Ma. Xenia G. , Fuh Katherine C. , Longmore Gregory D.
Published: May 2024

CRISPR/Cas9 mediated knockdown of mRor2
Supplementary Figure 3 from ROR2/Wnt5a Signaling Regulates Directional Cell Migration and Early Tumor Cell Invasion in Ovarian Cancer
Authors: Grither Whitney R. , Baker Breanna , Morikis Vasilios A. , Ilagan Ma. Xenia G. , Fuh Katherine C. , Longmore Gregory D.
Published: May 2024

ROR2 mutants and additional clearance assay data
Supplementary Table 3 from SCUBE3 Exerts a Tumor-Promoting Effect in Tongue Squamous Cell Carcinoma by Promoting CEBPA Binding to the CCL2 Promoter
Authors: Zhu Minhui , Ma Yi , Wang Wei , Li Meng , Chen Shicai , Liu Fei , Shi Xiaoqiong , Bi Hongsen , Zhang Chen , Nie Fangfei , Zheng Hongliang , Zhang Caiyun
Published: May 2024

Table S3. Antibodies applied in Western blot and co-IP assay of this research.
Supplementary Figure 2 from Unraveling the Global Proteome and Phosphoproteome of Prostate Cancer Patient-Derived Xenografts
Authors: Sychev Zoi E. , Day Abderrahman , Bergom Hannah E. , Larson Gabrianne , Ali Atef , Ludwig Megan , Boytim Ella , Coleman Ilsa , Corey Eva , Plymate Stephen R. , Nelson Peter S. , Hwang Justin H. , Drake Justin M.
Published: May 2024

Supplementary Figure 2. Immunohistochemical staining of representative LuCaP adenocarcinoma (AdCa) LuCaP77
Supplementary Figure 2 from An Endosomal Acid-Regulatory Feedback System Rewires Cytosolic cAMP Metabolism and Drives Tumor Progression
Authors: Prasad Hari , Mandal Susmita , Mathew John Kandam Kulathu , Cherukunnath Aparna , Duddu Atchuta Srinivas , Banerjee Mallar , Ramani Harini , Bhat Ramray , Jolly Mohit Kumar , Visweswariah Sandhya S.
Published: May 2024

Supplementary Figure 2 shows data on how NHE9 expression corresponds with EMT status in normal epithelial and mesenchymal populations of the intestine, and in human cancer cells.
Supplementary Figure S3 from Combination of an Autoantibody Panel and Alpha-Fetoprotein for Early Detection of Hepatitis B Virus-Associated Hepatocellular Carcinoma
Authors: Shen Yajing , Chen Jiajun , Wu Jinyu , Li Tiandong , Yi Chuncheng , Wang Keyan , Wang Peng , Sun Changqing , Ye Hua
Published: May 2024

Supplementary Figure S3: A total of 964 genes were identified by weighted gene co-expression network analysis (WGCNA) and difference analysis (GSE22058, GSE55092 and GSE121248). And four TAAs (ZIC2, PCNA, CDC37L1 and DUSP6) were identified by an intersection of the human proteome microarray and bioinformatics analysis.
Supplementary Table 5 from Triple Primary Cancers: An Analysis of Genetic and Environmental Factors
Authors: Borja Nicholas A. , Silva-Smith Rachel , Calfa Carmen , Sussman Daniel A. , Tekin Mustafa
Published: May 2024

Supplementary Table 5: Summary of the hereditary cancer germline sequencing performed for each patient in the MPC cohort
Economic Considerations for Implementing Tobacco Cessation Programs in Cancer Care Settings
Authors: Salloum Ramzi G. , Shoenbill Kimberly A. , Goldstein Adam O.
Published: May 2024

Increasingly, research demonstrates economic benefits of tobacco cessation in cancer care, as seen in a new study by Kypriotakis and colleagues of the MD Anderson cessation program, demonstrating median health care cost savings of $1,095 per patient over 3 months. While the cost-effectiveness of tobacco cessation programs from a hospital perspective is important, implementation decisions in a predominantly fee-for-service system, such as in the United States, too often insufficiently value this outcome. Economic barriers, stakeholder disincentives, and payment models all impact program implementation. Combining economic evaluation with implementation research, including assessment of return-on-investment, may enhance sustainability and inform decision-making in cancer care settings.

See related article by Kypriotakis et al., p. 217
Figure S12 from High-Dimensional Analyses Reveal IL15 Enhances Activation of Sipuleucel-T Lymphocyte Subsets and Reverses Immunoresistance
Authors: Saeed Muhammad A. , Peng Bo , Kim Kevin , Rawat Kavita , Kuehm Lindsey M. , Siegel Zoe R. , Borkowski Ariel , Habib Nabih , Van Tine Brian , Sheikh Nadeem , Tuyen Vu , Thorek Daniel L.J. , Fehniger Todd A. , Pachynski Russell K.
Published: May 2024

Correlation plots between clinical outcomes and sip-T subsets
Figure S8 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms
Authors: Tian Jane , Ashique Amir M. , Weeks Sabrina , Lan Tian , Yang Hong , Chen Hung-I Harry , Song Christina , Koyano Kikuye , Mondal Kalyani , Tsai Daniel , Cheung Isla , Moshrefi Mehrdad , Kekatpure Avantika , Fan Bin , Li Betty , Qurashi Samir , Rocha Lauren , Aguayo Jonathan , Rodgers Col , Meza Marchelle , Heeke Darren , Medfisch Sara M. , Chu Chun , Starck Shelley , Basak Nandini Pal , Sankaran Satish , Malhotra Mohit , Crawley Suzanne , Tran Thomas-Toan , Duey Dana Y. , Ho Carmence , Mikaelian Igor , Liu Wenhui , Rivera Lee B. , Huang Jiawei , Paavola Kevin J. , O'Hollaren Kyle , Blum Lisa K. , Lin Vicky Y. , Chen Peirong , Iyer Anjushree , He Sisi , Roda Julie M. , Wang Yan , Sissons James , Kutach Alan K. , Kaplan Daniel D. , Stone Geoffrey W.
Published: May 2024

Supplementary Figure S8
Figure S7 from Chronic Stress Exacerbates the Immunosuppressive Microenvironment and Progression of Gliomas by Reducing Secretion of CCL3
Authors: Wang Xu , Zhang Long , Zhou Yi , Wang Yan , Wang Xiang , Zhang Yining , Quan Ankang , Mao Yufei , Zhang Yu , Qi Ji , Ren Zhongyu , Gu Linbo , Yu Rutong , Zhou Xiuping
Published: May 2024

Supplementary Figure 7. The expression of CCR1 and CCR5 in cell subtypes of glioma tissues analyzed by single-cell sequencing
Figure S5 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells
Authors: Zhang Qunfang , Zheng Fang , Chen Yuchao , Liang Chun-Ling , Liu Huazhen , Qiu Feifei , Liu Yunshan , Huang Hongfeng , Lu Weihui , Dai Zhenhua
Published: May 2024

HI-TOPK-032 inhibits AKT/mTOR signaling in CAR-T cells.
Figure S1 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells
Authors: Zhang Qunfang , Zheng Fang , Chen Yuchao , Liang Chun-Ling , Liu Huazhen , Qiu Feifei , Liu Yunshan , Huang Hongfeng , Lu Weihui , Dai Zhenhua
Published: May 2024

Gating strategy used for CD8+ CAR-T cells from the tumor-bearing mice
The Effect of Bimodal Hearing on Postoperative Quality of Life
Authors: Schlacter Jamie A. , Asfour Leena , Morrissette Margareta , Shapiro William , Spitzer Emily , Waltzman Susan B.
Published: May 2024

Introduction: The aim of this study was to examine how bimodal stimulation affects quality of life (QOL) during the postoperative period following cochlear implantation (CI). These data could potentially provide evidence to encourage more bimodal candidates to continue hearing aid (HA) use after CI. Methods: In this prospective study, patients completed preoperative and 1-, 3-, and 6-month post-activation QOL surveys on listening effort, speech perception, sound quality/localization, and hearing handicap. Fifteen HA users who were candidates for contralateral CI completed the study (mean age 65.6 years). Results: Patients used both devices at a median rate of 97%, 97%, and 98% of the time at 1, 3, and 6 months, respectively. On average, patients’ hearing handicap scores decreased by 16% at 1 month, 36% at 3 months, and 30% at 6 months. Patients’ listening effort scores decreased by a mean of 10.8% at 1 month, 12.6% at 3 months, and 18.7% at 6 months. Localization significantly improved by 24.3% at 1 month and remained steady. There was no significant improvement in sound quality scores. Conclusion: Bimodal listeners should expect QOL to improve, and listening effort and localization are generally optimized using CI and HA compared to CI alone. Some scores improved at earlier time points than others, suggesting bimodal auditory skills may develop at different rates.
Multiple-Community-Based Epidemiological Study of Stuttering among 3-Year-Old Children in Japan
Authors: Sakai Naomi , Miyamoto Shoko , Hara Yuki , Kikuchi Yoshikazu , Kobayashi Hiroaki , Takeyama Takaaki , Udaka Jiro , Sudo Daisuke , Mori Koichi
Published: May 2024

Introduction: Many epidemiological studies of the disorder of stuttering have been conducted during the 20th century, continuing during the current one. Unfortunately, only a few were carried out in Japan. This study aimed at assessing (1) the incidence and prevalence of stuttering in 3-year-old children in multiple Japanese communities and (2) factors associated with the onset of stuttering among these children. Methods: A questionnaire aimed at screening for the presence of stuttering was employed for 2,055 children aged 3 years, who underwent a standard nationwide health checkup. Positive responses were confirmed in several ways: (1) direct interviews and assessment of the child’s speech, (2) confirmatory questionnaire, or (3) telephone interviews by licensed Speech Language Hearing Therapists. Results: Approximately 6.5% of the children were found to exhibit stuttering at the time of their health checkup. This figure rose to 8.9% after including individuals who previously, but not currently, were reported to have exhibited stuttering. Among the putative risk factors, higher stuttering odds (odds ratio, OR = 3.27) were detected in those with a family history of stuttering, those whose guardians had concerns about their child’s development (OR = 1.75), and those with diagnosed diseases or disabilities (OR = 2.13). Discussion/Conclusions: It was concluded that, in Japan, both the risk of stuttering incidence (8.9%) in children up to, and including, the age of 3 years, as well as its prevalence (6.5%) in this population, was similar to those reported by recent studies in other countries. Additionally, our findings also confirmed that an increased risk for stuttering at age 3 is associated with a family history of stuttering.
Flipped Classroom: Effect on the Academic Performance and Motivation of Grade 8 Students in Mathematics
Authors: Baybayan Jericho Y. , Cabanes Aileen
Published: May 2024

Teachers nowadays are being challenged due to continuous decrease in the analytical and numerical ability of the students. Strategies were continuously studied by teachers to address such concern answering also questions such as how students perceived flipped classroom setting as an aid to the teaching learning process. This study utilized descriptive quasi-experimental design through 189 Grade 8 students where it had found out that in terms of the Pre-Assessment results, most of the students are in the “did not meet expectation” category but still are motivated in terms of Performance Task Making, Problem Solving, Classroom Participation and Examination. In terms of the post-assessment results, most of the students are in the “satisfactory” category and are highly motivated in terms of Performance Task Making, and motivated in Problem Solving, Classroom Participation and Examination. There is a significant improvement in the academic performance of the students where post-assessment results showed higher mean score than the pre-assessment results. There is a positive significant relationship between Performance and Level of Motivation. The main issues and concerns of the students in the implementation of flipped classroom is the slow internet connection at school and at home. Thus, concludes that indeed Flipped Classroom Learning is a way to better improve education identifying the effect on the academic performance and motivation of students in mathematics noting also that internet connection plays a crucial role in this type of learning setting.
Millennial Dance Craze for The Well-Being of Teachers: A Multiple Case Study
Authors: Santos Sahlee A.
Published: May 2024

This study was designed to determine the impact of secondary school teachers' engagement with the millennial dance craze on their teaching and their well-being. Observing teachers' coping mechanisms and factors on fitness, increasing workload demands while having active leisure and social connections, and promoting the importance of teachers' physical and mental well-being motivated the researcher to pursue the investigation on the secondary school teachers' engagement with the millennial dance craze. Qualitative procedures were employed in this case study. Results revealed that secondary teachers' participation in the millennial dance craze is essential since it demonstrates personal explorations and transformation as reflected from their assessment on how their engagement with the millennial dance craze have affected them. As a result, they come to value the millennial dancing craze, which aids teachers' emotional and social development as well as their physical and mental health by allowing them to explore other aspects of life. It is advised that secondary level teachers take part in all types of dances, not just millennial dances, as this will give them the chance to be active, boost their confidence, and learn other important life lessons.
Perdagangan Manusia di Asia Tenggara: Fenomena, Penanganan, dan Respons Regional
Authors: Pinatih Ni Komang Desy Arya , Purwanti Asih , Mahendra Yustika Citra , Aulady Adela Rey , Aryaguna Amani Sabila , Hafish Brylian Arkaan Nata , Wibowo Salwa Izdihar , Aulia Nur Hidayah , Pradnyadyani I Gusti Ayu Agung Putu Diva , Zuliantina Odystia , Widihapsari Teresa , Sekarayu Kintan , Aurelia Ananda Resky
Published: May 2024

Isu perdagangan manusia diketahui merupakan salah satu jenis kejahatan transnasional yang cukup besar mengancam kawasan Asia Tenggara. Buku ini akan memudahkan pembaca mengetahui lebih jauh terkait fenomena perdagangan manusia, respons regional, hingga penanganan kejahatan tersebut di kawasan Asia Tenggara. Melalui penelitian mendalam dari beberapa penulis, Bagian A pada tulisan ini membedah terkait efektivitas penanganan perdagangan manusia di Provinsi Jawa Timur, faktor-faktor perdagangan manusia dari Myanmar ke Thailand dan Filipina ke China, fenomena perdagangan manusia di Perbatasan Entikong, hingga fenomena peningkatan perdagangan manusia di Thailand. Selanjutnya, Bagian B pada buku ini mengeksplorasi terkait upaya penanganan yang dilakukan oleh pemerintah untuk memerangi perdagangan manusia, meliputi kerja sama yang dilakukan baik oleh Indonesia maupun Thailand untuk menangani perdagangan manusia di negaranya, kemitraan Australia Indonesia Partnership for Justice 2 untuk menangani perdagangan manusia di Provinsi Sulawesi Selatan, kerja sama Australia dan Indonesia untuk mengatasi perdagangan manusia melalui Australia-Asia Program to Combat Trafficking in Person (AAPTIP), hingga sekuritisasi terkait isu perdagangan manusia yang dilakukan oleh Perdana Menteri Prayut Chan-O di Thailand maupun upaya sekuritisasi yang dilakukan Pemerintah Kabupaten Indramayu untuk melindungi dan mencegah terjadinya perdagangan manusia terhadap para PMI. Terakhir, Bagian C pada buku ini menggali lebih dalam terkait respons regional Asia Tenggara terhadap perdagangan manusia, dengan membahas mengenai peran ASEANAPOL, International Organization for Migration (IOM), ASEAN Convention Against Trafficking in Person (ACTIP) dan ASEAN Community Vision 2045 untuk menangani perdagangan manusia di Indonesia. Bagi para pembaca yang memiliki minat untuk mengetahui lebih dalam terkait fenomena perdagangan manusia, maka buku ini menjadi pilihan yang sangat tepat untuk dibaca dan diharapkan dapat membantu membuka mata para pembuat kebijakan, aktivis, cendekiawan, serta masyarakat luas untuk ikut berdedikasi memberantas perdagangan manusia di Asia Tenggara.
Trem2 Agonist Reprograms Foamy Macrophages to Promote Atherosclerotic Plaque Stability—Brief Report
Authors: Patterson Michael T. , Xu Yingzheng , Hillman Hannah , Osinski Victoria , Schrank Patricia R. , Kennedy Ainsley E. , Barrow Fanta , Zhu Alisha , Tollison Samuel , Shekhar Sia , Stromnes Ingunn M. , Tassi Ilaria , Wu Dick , Revelo Xavier S. , Binstadt Bryce A. , Williams Jesse W.
Published: May 2024

BACKGROUND:

Trem2 (triggering receptor on myeloid cells 2), a surface lipid receptor, is expressed on foamy macrophages within atherosclerotic lesions and regulates cell survival, proliferation, and anti-inflammatory responses. Studies examining the role of Trem2 in atherosclerosis have shown that deletion of Trem2 leads to impaired foamy macrophage lipid uptake, proliferation, survival, and cholesterol efflux. Thus, we tested the hypothesis that administration of a Trem2 agonist antibody (AL002a) to atherogenic mice would enhance macrophage survival and decrease necrotic core formation to improve plaque stability.

METHODS:

To model a therapeutic intervention approach, atherosclerosis-prone mice (Ldlr [low-density lipoprotein receptor]
−/−
) were fed a high-fat diet for 8 weeks, then transitioned to treatment with AL002a or isotype control for an additional 8 weeks while continuing on a high-fat diet.

RESULTS:

AL002a-treated mice had increased lesion size in both the aortic root and whole mount aorta, which correlated with an expansion of plaque macrophage area. This expansion was due to increased macrophage survival and proliferation in plaques. Importantly, plaques from AL002a-treated mice showed improved features of plaque stability, including smaller necrotic cores, increased fibrous caps, and greater collagen deposition. Single-cell RNA sequencing of whole aorta suspensions from isotype- and AL002a-treated atherosclerotic mice revealed that Trem2 agonism dramatically altered foamy macrophage transcriptome. This included upregulation of oxidative phosphorylation and increased expression of collagen genes. In vitro studies validated that Trem2 agonism with AL002a promoted foamy macrophage oxidized low-density lipoprotein uptake, survival, and cholesterol efflux.

CONCLUSIONS:

Trem2 agonism expands atherosclerotic plaque macrophages by promoting cell survival and proliferation but improves features of plaque stability by rewiring foamy macrophage function to enhance cholesterol efflux and collagen deposition.
Angiogenic Gene Therapy for Refractory Angina: Results of the EXACT Phase 2 Trial
Authors: Nakamura Kenta , Henry Timothy D. , Traverse Jay H. , Latter David A. , Mokadam Nahush A. , Answini Geoffrey A. , Williams Adam R. , Sun Benjamin C. , Burke Christopher R. , Bakaeen Faisal G. , DiCarli Marcelo F. , Chaitman Bernard R. , Peterson Mark W. , Byrnes Dawn G. , Ohman E. Magnus , Pepine Carl J. , Crystal Ronald G. , Rosengart Todd K. , Kowalewski Elaine , Koch Gary G. , Dittrich Howard C. , Povsic Thomas J. ,   on behalf of the EXACT Trial Investigators
Published: May 2024

BACKGROUND:

XC001 is a novel adenoviral-5 vector designed to express multiple isoforms of VEGF (vascular endothelial growth factor) and more safely and potently induce angiogenesis. The EXACT trial (Epicardial Delivery of XC001 Gene Therapy for Refractory Angina Coronary Treatment) assessed the safety and preliminary efficacy of XC001 in patients with no option refractory angina.

METHODS:

In this single-arm, multicenter, open-label trial, 32 patients with no option refractory angina received a single treatment of XC001 (1×10
11
viral particles) via transepicardial delivery.

RESULTS:

There were no severe adverse events attributed to the study drug. Twenty expected severe adverse events in 13 patients were related to the surgical procedure. Total exercise duration increased from a mean±SD of 359.9±105.55 seconds at baseline to 448.2±168.45 (3 months), 449.2±175.9 (6 months), and 477.6±174.7 (12 months; +88.3 [95% CI, 37.1–139.5], +84.5 [95% CI, 34.1–134.9], and +115.5 [95% CI, 59.1–171.9]). Total myocardial perfusion deficit on positron emission tomography imaging decreased by 10.2% (95% CI, −3.1% to 23.5%), 14.3% (95% CI, 2.8%–25.7%), and 10.2% (95% CI, −0.8% to −21.2%). Angina frequency decreased from a mean±SD 12.2±12.5 episodes to 5.2±7.2 (3 months), 5.1±7.8 (6 months), and 2.7±4.8 (12 months), with an average decrease of 7.7 (95% CI, 4.1–11.3), 6.6 (95% CI, 3.5–9.7), and 8.8 (4.6–13.0) episodes at 3, 6, and 12 months. Angina class improved in 81% of participants at 6 months.

CONCLUSIONS:

XC001 administered via transepicardial delivery is safe and generally well tolerated. Exploratory improvements in total exercise duration, ischemic burden, and subjective measures support a biologic effect sustained to 12 months, warranting further investigation.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT04125732.
Contributions of Basal Ganglia Circuits to Perception, Attention, and Consciousness
Authors: Redinbaugh Michelle J. , Saalmann Yuri B.
Published: May 2024

Research into ascending sensory pathways and cortical networks has generated detailed models of perception. These same cortical regions are strongly connected to subcortical structures, such as the basal ganglia (BG), which have been conceptualized as playing key roles in reinforcement learning and action selection. However, because the BG amasses experiential evidence from higher and lower levels of cortical hierarchies, as well as higher-order thalamus, it is well positioned to dynamically influence perception. Here, we review anatomical, functional, and clinical evidence to demonstrate how the BG can influence perceptual processing and conscious states. This depends on the integrative relationship between cortex, BG, and thalamus, which allows contributions to sensory gating, predictive processing, selective attention, and representation of the temporal structure of events.
The Battle at Lake Changjin: The Influence of Korean War Memory on Contemporary Chinese War Films
Authors: Kotowski Matthew
Published: May 2024

The 2021 film The Battle at Lake Changjin (长津湖) is China’s highest-grossing film. Together with its sequel, its success as a political tool rests on appealing to a broad audience while engaging with familiar themes embedded in collective memory. The Chinese Communist Party, which commissioned the films, leveraged preexisting tropes regarding the conflict and repackaged them for a modern audience. This paper will proceed in three parts. First, it will trace the deliberate development of collective memory of the conflict from its inception up to President Xi Jinping’s gaining power in 2012. Next, it will explore the new emphasis on the Korean War in the 2010s and 2020s, and the political objectives Xi seeks to achieve by propagandizing the Korean War. Finally, it will provide a thematic analysis of the films and how the intended political messaging interacted with the embedded collective memory.
Taxonomic revision of Mozambique dung beetle species in the genus Diastellopalpus van Lansberge, 1886 (Coleoptera: Scarabaeidae: Scarabaeinae)
Authors: DANIEL GIMO M. , STRÜMPHER WERNER P. , JOSSO JEAN-FRANÇOIS , DAVIS ADRIAN L.V.
Published: May 2024

Recently, there has been growing attention paid to the Mozambican dung beetle fauna, including the description of several new species. In this paper, we revise the taxonomy of species recorded from Mozambique in the genus Diastellopalpus van Lansberge, 1886, including the description of Diastellopalpus scholtzi Daniel, Strümpher, Josso & Davis, new species. We also report a new country record for Diastellopalpus neavei (d’Orbigny, 1914). Moreover, Diastellopalpus orbignyi Péringuey, 1904 is removed from subjective synonymy with Diastellopalpus infernalis van Lansberge, 1887 and proposed as a valid species. Currently, Mozambique encompasses five valid species of the genus Diastellopalpus, namely: Diastellopalpus infernalis van Lansberge, 1887, D. quinquedens Bates, 1888, D. neavei, D. orbignyi and D. scholtzi, new species. We redescribe the former four species and include an examination of the types of their junior synonyms. Furthermore, we diagnose, illustrate, and provide a distribution map for all five species and compare them to the morphologically most similar species in the genus. We designate lectotypes for the following species-group taxa: Diastellopalpus nyassicus Kolbe, 1901, D. orbignyi, D. quinquedens Bates, 1888, Onthophagus ponderosus Péringuey, 1896, and O. tridepressus d’Orbigny, 1902. Finally, we provide an updated identification key for the species of Diastellopalpus recorded from Mozambique.
First record of the genus Haritalodes Warren, 1890 and H. derogata (Fabricius, 1775) (Lepidoptera: Crambidae: Spilomelinae) from Türkiye and its morphological and molecular identification
Authors: SEZEN KAZIM , AYDIN EBRU GÜNEY , YILDIZ HASRET SIMGE , YILDIZ ISLAM , CAN FEZA , GHANBARI SOLMAZ , TOPRAK UMUT
Published: May 2024

The genus Haritalodes Warren, 1890 is represented by 12 species worldwide except in the Nearctic and Neotropical regions. Haritalodes derogata (Fabricius, 1775), commonly known as the cotton leaf roller moth, is the most widely distributed species of the genus and is common in the West Palaearctic Region. This species is one of the most serious pests of Malvaceae. The larvae primarily feed on the leaves, and severe population levels may lead to significant yield loss in the primary host, cotton. In a survey in 2023, the shrubs of the Hibiscus sp. were found to be infested by a group of larvae with a very dense population feeding on the leaves in Trabzon Province, Türkiye. The larvae were reared for pupation and adult emergence. Morphological identification according to male and female genitalia as well as sequencing of the mitochondrial cytochrome oxidase region I (COI) from larvae and adults revealed that the species is H. derogata. This is the first report of the genus Haritalodes and Haritalodes derogata in Türkiye.
A Numerical Study of Smoke Concentration Distribution near Low-Intensity Fires: Sensitivity to Vertical Canopy Structure and Fire Heat Source Strength
Authors: Kiefer Michael T. , Zhong Shiyuan , Charney Joseph J. , Bian Xindi , Heilman Warren E. , Seitz Joseph
Published: May 2024

Broadly speaking, prediction of the negative impacts of prescribed fire on air quality is limited by gaps in our understanding of the underlying fire, fuels, and atmospheric processes. These knowledge gaps hinder our ability to accurately predict smoke concentration distributions, leading to unintended smoke intrusions into nearby communities and subsequent threats to public health and safety. In this study, numerical simulations are performed using the Flexible Particle Weather Research and Forecasting (FLEXPART-WRF) Model, a Lagrangian particle dispersion model, with particle motion driven by output from a full-physics atmospheric model with a forest canopy submodel and 10-m horizontal grid spacing [Advanced Regional Prediction System (ARPS)-CANOPY], to address two research questions. First, what is the relationship between near-fire (within ∼50–150 m of fire) smoke concentration distribution and (i) vertical canopy structure and (ii) fire heat source strength? Second, what roles do mean transport (i.e., transport by the mean wind) and turbulent diffusion play in shaping the near-fire smoke concentration distribution? To address these questions, simulations are run with 25 combinations of plant area density profile and fire sensible heat flux magnitude, and smoke is represented by particles with diameters ≤ 2.5 μm (PM2.5). Results show that near-fire PM2.5 concentration distribution is primarily controlled by vertical canopy structure, with fire heat source strength primarily controlling the PM2.5 concentration magnitude. Analysis of the underlying ARPS-CANOPY variables driving the FLEXPART-WRF particle dispersion helps elucidate the roles of mean transport and turbulent diffusion. In total, the study findings suggest that the vertical distribution of canopy vegetation and fire heat source strength are important factors influencing PM2.5 dispersion and concentration distribution near low-intensity fires.
Structural adjustment, partisan alignment, and protest in the developing world
Authors: Reinsberg Bernhard , Abouharb M Rodwan
Published: May 2024

When do IMF programs induce protest? Despite much cross-country research on this question, there is little evidence on how IMF programs affect individual predispositions for protest and protest behavior. This article argues that governments facing IMF conditionality allocate adjustment burdens strategically, protecting their partisan supporters while punishing supporters of the political opposition. This intensification of distributional politics under IMF programs will increase protests by opposition supporters. To test this argument, we utilize a mixed-method strategy combining individual-level survey evidence from 12 sub-Saharan African countries and an intertemporal case study of Kenya. The results find strong evidence for our argument. Opposition supporters are significantly more likely to protest when a government goes under an IMF program, especially when the program entails public-sector conditions. Our analysis suggests that governments are not innocent bystanders in the adjustment process. Instead, they co-determine inclinations for protest by deciding over the allocation of adjustment burdens to the detriment of opposition groups and the benefit of their supporters. These results have important implications for the role of governments as purveyors of pressures for global policy reform induced by international financial institutions.
Portuguese Caregivers of Persons With Alzheimer’s Disease in the Context of the COVID-19 Pandemic: A Qualitative Study of the Grieving Process
Authors: Brito Laura , Bernardo Ana Cristina , Leite Ângela , Pereira M. Graça
Published: May 2024

This study addresses the experiences of informal caregivers caring for elderly family members with Alzheimer’s disease (AD) during the COVID-19 pandemic. The study includes a sample of eight informal caregivers who were evaluated through a semi-structured interview six months after the death of a loved one they cared for. A thematic content analysis was applied to the interviews and yielded two higher-order domains: (1) Experiencing the AD and the death of a family member and (2) The grieving process during the COVID-19 pandemic. The results provide valuable insights into family caregivers' experiences regarding the profound emotional impact of caregiving and grief during the COVID-19 pandemic. Caregivers maintain their identity even after loss, underscoring the enduring impact of caregiving. The identity as a caregiver impacted coping and grief responses, highlighting the need for tailored interventions.
Past, Present, and Future Diagnostic Methods for the Early Noninvasive Detection of Oral Premalignant Lesions: A State of the Art and Systematic Review
Authors: Khong Brendan , Ferlito Salvatore , Quek Stuart , Conte Gianluca , Ingrassia Angelo , Lechien Jerome Rene , Chiesa-Estomba Carlos , Mayo Miguel , Maniaci Antonino , Radulesco Thomas , Michel Justin , Fakhry Nicolas , Polosa Riccardo
Published: May 2024

Objectives: To provide an in-depth analysis of noninvasive methods for the early diagnosis of oral premalignant lesions, focusing on novel biomarkers and optical technologies, and to discuss their potential in improving the prognosis of patients with oral oncological diseases. Methods: This state-of-the-art review examines various noninvasive diagnostic techniques, including the utilization of salivary microRNAs and optical technologies such as Raman spectroscopy, elastic scattering spectroscopy, diffuse reflectance spectroscopy, narrow-band imaging, autofluorescence imaging, toluidine blue staining, and microendoscopy. Results: Several noninvasive techniques have shown varying degrees of effectiveness in detecting oral cancer. Autofluorescence imaging exhibited sensitivities up to 100% but had variable specificity. toluidine blue staining reported sensitivity between 77% and 100% for high-risk lesions or cancer, with specificity around 45% to 67%. Spectroscopy techniques achieved 72% to 100% sensitivities and specificities of 75% to 98%. Microendoscopy presented a sensitivity of 84% to 95% and a specificity of 91% to 95%. Conclusion: The review highlights the strengths and limitations of each noninvasive diagnostic method and their recent advancements. Although promising results have been demonstrated, there is a need for further development of reliable strategies for early detection and intervention in oral oncology.
Taking intra-executive politics into public arenas? Analysis of presidential speeches in six semi-presidential European countries
Authors: Kujanen Maarika , Koskimaa Vesa , Raunio Tapio
Published: May 2024

Although public communication is a key aspect of political leadership, there is no systematic comparative research on the speeches of presidents in European semi-presidential countries. In such regimes, constitutionally weaker presidents are tempted to use the public podium for increasing their influence, potentially igniting intra-executive quarrels that debilitate decision-making. To gauge this general dynamic, this article analyses the official speeches of Czech, Finnish, French, Polish, Portuguese and Romanian presidents between 2000 and 2020. It first explores the ‘politicalness’ of presidents’ public activity through the general tone and the share of references to economy in the speeches. It then examines how societal conditions, party-political dynamics and public opinion impact the tone and content of presidential addresses. Presidents largely adopt a positive or neutral tone even during cohabitation or economic downturn, but occasionally intervene in issues under the government’s jurisdiction. The results highlight the complex and precarious nature of semi-presidentialism.
Surgically challenging inflammatory myofibroblastic tumor: A rare neoplasm of lung
Authors: Chakraborty Nirupam Sekhar , Saurav Gaind Kumar , Kashyap Nitin , Suresh Pranay Mehsare , Borkar Nitin , Gupta Rakesh
Published: May 2024

Inflammatory myofibroblastic tumor is considered one of the rarest benign tumors constituting 0.7% of all lung neoplasms. It was first described in 1939. We report a case of a 10-year-old child who presented with recurrent cough and fever. Chest radiography and computed tomography demonstrated complete involvement of right lung by the tumor. The tumor along with the affected lung was meticulously dissected from the surrounding structures and was delivered outside. The histopathology of the specimen revealed it to be inflammatory fibroblastoma.
Postmortem pathologic findings in dogs that underwent total body irradiation and hematopoietic cell transplant: A case series of five dogs with B-cell multicentric lymphoma
Authors: Benedict William , Suter Steven , Meritet Danielle
Published: May 2024

Alternative therapies that can help achieve complete remission in dogs with lymphoma include total body irradiation and hematopoietic cell transplant, though there are few reports describing successes and pathologic sequelae of these procedures. During a 10-year period, 94 dogs with multicentric lymphoma received a hematopoietic cell transplant following total body irradiation at North Carolina State University College of Veterinary Medicine. Seven of these 94 dogs (7%) died prior to discharge, five (5%) of which presented for postmortem examination. Of these dogs, four received an autologous hematopoietic cell transplant, while one received a haploidentical allogeneic hematopoietic cell transplant. All five dogs had bone marrow depletion with all hematopoietic lines affected. Three had systemic candidiasis, while two had bacterial infections. To the authors’ knowledge, this is the first report to document pathologic findings and development of systemic mycoses in dogs post total-body irradiation therapy and hematopoietic cell transplant.
Premorbid functional status in patients requiring veno-arterial extracorporeal membrane oxygenation after cardiac surgery
Authors: Bradshaw AlleaBelle , Briscoe Jessica , Sanghavi Kavya , Taurone Blake , Vantair Nidhi , Gilbreth Jacob , Zaaqoq Akram M
Published: May 2024

Assessment of a patient’s functional status prior to undergoing cardiac surgery may be a useful marker for predicting outcomes when postoperative veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is required. In this short communication, we present retrospective data on 83 patients at a single center who required V-A ECMO after cardiac surgery. Our results did not show a statistically significant association between premorbid functional status and mortality, though age was predictive of mortality. Future studies should explore other markers of functional status and relationships with additional outcomes.
Recycling of mineral wool waste as supplementary cementitious material through thermochemical treatment
Authors: Doschek-Held Klaus , Krammer Anna Christine , Steindl Florian Roman , Sattler Theresa , Juhart Joachim
Published: May 2024

Mineral wool is commonly used in construction as thermal insulation material. After the product’s lifetime, it is classified as hazardous waste if no trademark of the European Certification Board for Mineral Wool Products (EUCEB) or the German Institute for Quality Assurance and Labelling (RAL) exists. Mineral Wool Waste (MWW) is typically landfilled in Europe, which is challenging due to its low bulk density and dimensional stability. This circumstance highlights the need for alternative recycling methods that increase the recycling rate of construction and demolition (C&D) waste. This article outlines the recycling opportunities of MWW and focuses on the use of thermochemical treatment of different mixtures of input materials to produce a supplementary cementitious material (SCM). The material characterisation results and investigations on the binder suitability demonstrate that the slag fractions after the thermochemical treatment are well-qualified to be used as reactive binder components. Additionally, a material flow analysis was conducted to estimate the substitution potential of MWW as SCM in the Austrian cement industry.
Management and Pharmacological Treatment of Peripheral Arterial Disease
Authors: Leatham Samantha J. , Winckel Karl R. , De Guzman Keshia R.
Published: May 2024

Background: Peripheral arterial disease (PAD) is a complex, heterogeneous condition that has become a leading health concern globally. Peripheral arterial disease often co-exists with other vascular disease states, including cerebrovascular and cardiovascular disease. Optimal therapy for managing symptoms and progression of disease employs non-pharmacological, pharmacological, and contemporary revascularisation techniques to improve clinical outcomes and quality of life. However, large well-designed randomised control trials (RCT) and corresponding evidence-based guidelines for management of PAD are lacking, with current practice standards often extrapolated from evidence in coronary artery disease. Purpose: This review article aims to discuss currently accepted best pharmacological practice for PAD. Method: Relevant articles were searched between May 2023 and January 2024 through PubMed, Cochrane Library, Google Scholar and international guidelines, focusing on pharmacological management for PAD. Results: This narrative review discusses holistic pharmacological treatments for PAD.
A non-uniform lattice design method for lightweight structures in 3D printing
Authors: Zhong Zhengji , Shen Ciming , Li Bo
Published: May 2024

Lightweight design is an essential topic in aerospace, automotive and other fields. In automobile manufacturing, the engine connecting rod is one of the main components; its lightweight design has a high reference value. And 3D printing provides a feasible solution for designing and manufacturing lightweight structures. Unlike the traditional geometrically homogeneous point design, this study offers a non-homogeneous point design method based on the spatial stress state of additively manufactured components. After numerical simulation of quasi-static stresses on a model of an engine connecting rod, finite element grid cells with different stress values are replaced by lattice cells with different specific stiffnesses at similar local stress levels. The overall specific stiffness of the structure is further improved by continuing the optimized design with the corresponding gradient-type reinforcement of the non-uniform lattice structure. The basic idea of this design is to perform non-uniform adaptive filling of solid parts under localized loading by employing different types of unit cells. Stereolithography 3D printing technology prepares the engine lattice structural parts for quasi-static compression comparison experiments and fracture analysis after failure. The conclusions show that the engine connecting rod members with non-homogeneous lattice have more excellent overall mechanical properties than homogeneous lattice members. This work demonstrates the feasibility of such design methods for 3D printing lightweight structures and optimization.
Effect of filler orientation on mechanical and thermal properties of microwave absorbent 3D printed polycaprolactone/carbonyl iron particle composites
Authors: Rath Usharani , Pandey Pulak M
Published: May 2024

A thorough investigation was conducted in the present work on the mechanical and thermal characteristics of polycaprolactone/carbonyl iron particle composites. For composite fabrication, 3D printing technique was utilized. The fabricated composites were categorized as oriented, non-oriented and polycaprolactone samples based on orientation and concentration of filler particle. To evaluate the effect of orientation of carbonyl iron particle, two orientation directions, viz. parallel orientation, and perpendicular orientation with respect to loading direction were tried. The sample with parallel orientation exhibited the highest tensile strength followed by 90° orientation and pure polycaprolactone samples respectively. Oriented composites exhibited elevated dynamic modulus in comparison to the composites without orientation. The oriented composites demonstrated stiffness and tensile strength in the order of 13.66 ± 0.94 MPa and 3.79 ± 0.26 MPa respectively. The proposed methodology in the present study can be used to align carbonyl iron fillers in polymer matrix to tailor the mechanical, viscoelastic, and degradation properties.