bluuebunny/crossref_metadata_2025 huggingface dataset:
A Multivariate Study for Determining the Relationship Between Physical Activity, Physical Fitness, and Academic Performance
Authors: Suárez-Cano Leonardo , Bernal-Ballén Andrés , Briceño Martínez John-Jairo
Published: April 2023

The relationship between physical activity, physical fitness, and academic performance has been widely studied internationally. However, reports of this relationship are contradictory, and its impact is still a matter of controversy. For that reason, the current research determined the correlation between these three variables in a group of 56 female and 48 male Colombian students with an average age of 14.08 ± 0.89 years. A quantitative, correlational, and cross-sectional study was carried out. The physical activity was evaluated using PAQ-A questionnaire. For physical fitness, six tests from the Euro fitness battery were used. The academic performance in Spanish, Math, Natural, and Social Sciences were obtained from the grades for the participants at the end of the academic year. Correlations were determined by multivariate multiple linear regression. The obtained results suggest that aerobic endurance test had effect in the studied variables, whereas the correlation of the other tested predictors did not show any meaningful statistical result. In fact, academic performance is not affected by the physical fitness of the students at the time course grades were measured.
Book Review - Mammals of Ohio, 2022. JD Harder, GN Cameron
Authors: Courts Roger
Published: April 2023

No abstract available.
Analysis on specific biometric approaches: ECG as one of its trait
Authors: Mageshbabu M. , Mohana J. , Gokulavani D. , Divya T.
Published: April 2023

A biometric is in fact a pattern recognition system that uses biological traits like fingerprints, voice recognition, facial geometry, and hand geometry in addition to different patterns like iris and retina. The fact that different data protection codes like authentications and ID cards can be shared, stolen, or copied is what makes biometric so alluring. Physiological characteristics can be applied to improve the system’s security and dependability. This paper provides an overview of the main biometric technologies, the fundamental techniques used, and the disadvantages of each. The paper then demonstrates how ECG operates and discusses various opportunities for ECG.
A case of oroantral fistula: managed successfully by buccal advancement flap
Authors: Lall A.B. , Bhardwaj A. , Kusum T. , Priyanka T.
Published: April 2023

Oral epithelium migrates into the defect when an oroantral communication lasts more than three weeks, at which point it is referred to as an oroantral fistula. Oroantral fistula (OAF) can arise for a variety of reasons, including the extraction of maxillary posterior teeth, treatments for sinus augmentation, the improper use of implant drills, trauma to the craniofacial region, osteoradionecrosis, and flap necrosis. The size of the pre-existing oroantral communication affects the oroantral fistula’s treatment strategy and outcome. Instances when the oroantral communication is lesser than 2 mm in diameter it’s likely to heal and close by itself, eliminating the need for any surgical intervention. However, surgical closure is advised when the oroantral communication is higher than 3 mm or linked to periodontal or maxillary infection. In the literature, a number of algorithms have been proposed to describe the surgical methods for treating oroantral fistulas. This article aims to discuss a case of oroantral fistula of a female patient aged 34 years who presented with the chief complaint of foul discharge from the nose since 2 months.
Profile of dyslipidemia among attendees of preventive OPD in a tertiary care hospital in district Ghaziabad - A Cross sectional study
Authors: Jaiswal A. , Agrawal D.
Published: April 2023

BACKGROUND: Cardiovascular diseases (CVD) are the major cause of morbidity and mortality in our society with Dyslipidemia contributing significantly to atherosclerosis. OBJECTIVE: To find proportion and distribution of Dyslipidemia among the apparently healthy young adult visiting the preventive OPD of a tertiary care Hospital. MATERIAL AND METHODS: The study was conducted for a period of 2 months --from 1st May 2022 to 30th June 2022. Based on inclusion and exclusion criteria 400 subjects (250 males and 150 females) with > or =40 age group were selected from a total no. of patients who had attended preventive OPD run by department of community medicine at Santosh medical college and hospital Ghaziabad. RESULTS: The total proportion of Dyslipidemia was found to be 23.75% among total study participants. The proportion of Dyslipidemia was observed to be higher in males than in females. Among participants who had a total Cholesterol (TC) concentration > or = 200 mg/dl, 44.8% were males and 24.8% were females. High density lipoprotein cholesterol (HDL-C) was abnormally low in 65.2% males and 34.7% in females. Isolated Low-density lipoprotein-C was abnormally high (>100 mg/dl) in 28% of males and 24.7% of females. Deranged levels of Total Cholesterol, Triglycerides and LDL levels found 24.8% in males and 22.6% in females. CONCLUSION: There is significant proportion of Dyslipidemia in healthy adults which indicates that there is a need for awareness programs for the prevention and control of Dyslipidemia.
Fine Needle Aspiration Cytology of Ganglion Cyst of the Knee
Authors: Verma A. , Aarthi K.B. , Garg P.K. , Singh S. , Tyagi M.S. , Pathre A. , Gupta R.K.
Published: April 2023

Ganglion cysts are benign soft tissue formations arising from the joint capsule or tendon sheath containing mucinous fluid. Most common locations are on the dorsum of the wrist, palm, and the dorsolateral aspect of the foot. Ganglion cysts within the knee joint are unusual findings and may produce clinical manifestations which mimic internal derangement of the knee. We present here a case of 85-year-old female came with complaints of swelling near the right knee. On examination the swelling was seen in medial aspect of right knee about 7x8cm. Fine Needle Aspiration was done and 2ml of gelatinous material obtained. Cytomorphological features are suggestive of Ganglionic cyst of Right Knee, which was then correlated and confirmed by MRI. Ganglion cyst of the knee usually present in locations atypical for popliteal cysts. It is important to derive the cystic nature of the lesion and its association with intra-articular diseases, for which FNAC plays an important role.
Comparison of Accuracy Rate in Prediction of Cardiovascular Disease using Random Forest with Logistic Regression
Authors: Vishnuvardhan T. , Rama A.
Published: April 2023

Aim: Comparison of accuracy rate in prediction of cardiovascular disease using Novel Random Forest with Logistic Regression. Materials and Methods: The Novel Random forest (N=20) and Novel Logistic Regression Algorithm (N=20) these two algorithms are calculated by using 2 Groups and taken 20 samples for both algorithm and accuracy in this work.The sample size is determined using the G power Calculator and it’s found to be 10. Results: The Random Forest exhibited 89.06% accuracy whilst a Logistic Regression has shown 92.18%. accuracy. Statistical significance difference between Random forest algorithm and Novel Logistic Regression Algorithm was found to be p=0.001 (2 tailed) (p<0.5). Conclusion: Prediction of cardiovascular disease using Logistic Regression is significantly better than the Random Forest.
Heart Plaque Detection with Improved Accuracy using Decision tree in comparison with Least Squares Support Vector Machine
Authors: Kumar V.S. , Vidhya K.
Published: April 2023

Aim: The main aim of this research is to detect heart plaque using the Decision Tree algorithm with improved accuracy and comparing it with Least Squares Support Vector Machine. Materials and Methods: Decision tree and Least squares Support Vector Machine algorithms are two groups compared in this study. Each group has 20 samples and calculations utilized pretest power of 0.08 with 95% confidence interval. The G power is estimated for samples using clincalc, which has two groups: alpha, power, and enrollment ratio. These samples are split into two groups: training dataset (n = 489 [70%]) and test dataset (n = 277 [30%]). Results: The accuracy obtained for Decision Tree was 68.13 % and 67.3 % for the Least Squares Support Vector Machine technique. Since p (2-tailed) < 0.05, in SPSS statistical analysis, a significant difference exists between the two groups. Conclusion: It is found that the Decision Tree algorithm is significantly better than the Least Squares Support Vector Machine algorithm in Heart plaque disease detection for the dataset considered.
Heart Plaque Detection with Improved Accuracy using K-Nearest Neighbors classifier Algorithm in comparison with Least Squares Support Vector Machine
Authors: Kumar V.S. , Vidhya K.
Published: April 2023

Aim: The objective of the work is to evaluate the performance of the k-Nearest Neighbor classifier in detecting heart plaque with high accuracy and comparing it with the Least Squares Support Vector Machine. Materials and Methods: The Kaggle dataset on Heart Plaque Disease yielded a total of 20 samples. Clincalc, which has two groups: alpha, power, and enrollment ratio, is used to assess G power of 0.08 with 95% confidence interval for samples. The training dataset (n = 489 [70 percent]) and the test dataset (n = 277 [30 percent]) are divided into two groups. Accuracy is used to assess the performance of the k-Nearest Neighbor algorithm and the Least Squares Support Vector Machine. Results: The accuracy of the k-Nearest Neighbor algorithm was 86 % and 67.3 % for the Least Squares Support Vector Machine technique. Since p (2-tailed) < 0.05, in SPSS statistical analysis, a significant difference exists between the two groups. Conclusion: In this work, the k-Nearest Neighbor algorithm outperformed the Least Squares Support Vector Machine algorithm in detecting heart plaque disease in the dataset under consideration.
Efficient and Reliable Multihop Routing for IoT Healthcare Applications
Authors: Nawaz N. , Meenakshi R. , Ramakrishnan R. , Chirputka A.
Published: April 2023

A wireless body area network (WBAN) collects several tiny sensor nodes in the human body. They are intended to observe data constantly forward and perform as critical structures for remote healthcare monitoring and healing. These protect the preferred reliability and efficiency of data transmissions of individual body sensors. However, with the restricted sensor energy, unreliable link connection, and complex channel environment, the design of efficient routing in Multihop WBANs is demanding. This article, Efficient and Reliable Multihop Routing (ERMR) for IoT Healthcare Applications, is proposed. The main concept is to incorporate a fuzzy-logic system to handle multiple cross-layer input variables independently. This approach uses the fuzzy logic method to select the optimal route in the WBAN. The fuzzy input like sensor node distance, link strength, energy, and node quality of Service and produce the output is a reliable forwarder selection. Simulation results demonstrate the proposed approach increases the network throughput and minimizes the network delay in the WBAN.
Comparative Analysis of Antibiofilm Properties of Fluorescein Derivatives Over Commercial Antibiotics
Authors: Yeshwanth S.S. , Sivaprasad S.
Published: April 2023

Aim: The study is about to compare the antibiofilm properties of Novel Fluorescein derivatives to those of commercial antibiotics, using docking to see how the ligand, protein, and antibiotic interact molecularly. Materials and methods: The 3D structures of protein and ligands were procured from the PubChem, Drug bank, and PDB databases. The sample size was calculated using G power with pretest power at 80% and alpha value of 0.05. The sample size per group is 10 and total sample size is 30. Docking studies of protein and ligands were performed using Auto dock software. Statistics of the interactions were analyzed using IBM SPSS software. Result: Protein ligand interactions revealed that fluorescein shows more binding affinity towards the protein compared to commercial antibiotics cephalexin and cephalexin monohydrate. The binding affinity values were compared using SPSS software, which reveals that the statistical insignificance observed between the fluorescein and antibiotics cephalexin and cephalexin monohydrate is 0.519 and 0.400 respectively. Conclusion: The fluorescein ligand appears to be more specific and selectively works against the target protein when compared to the antibiotics.
Environmental and Human Exposure Relevant Dose Analysis of Triclosan on Larval Zebrafish Heart Rate using Microscopic Observation for Risk Assessment Applications
Authors: Sushmitha P. , Kumar I.P.
Published: April 2023

Aim: The current study’s goal is to determine the impact of triclosan (TCS) concentrations in the environment and from human exposure on zebrafish larvae heart rate. Materials and Methods: Chemicals: TCS [CAS:3380-34-5, Purity-99%] was purchased from Loba Chemie, Mumbai, India. Stock solution of 1000 ppm was prepared using ethanol and autoclave water as solvents and stored at -20˚C in an amber coloured bottle. Maintenance of zebrafish and egg collection: Wild type, adult zebrafish were purchased from a local cultivator and are maintained in a light and dark cycle of 14:10h at 26±1 °C under static conditions. In order to obtain embryos, breeding groups were housed in a specific spawning tank in a male to female ratio of 1:1. Embryo toxicity assay: This work includes 2 groups and a total sample size of 106. Group 1 analyzed the environmental exposure relevant dose of TCS on larval zebrafish hatching rate whereas group 2 analyzed the human exposure relevant dose analysis of TCS on larval zebrafish hatching rate. Embryos were sorted out for each exposure group in petri plates, with n=53 embryos per plate and were exposed to TCS from 4 hpf – 96 hpf. Other conditions required for the validation of this study were maintained as stated by the OECD in the fish embryo toxicity assay guidelines. All the experiments were carried out in triplicate. Heart rate: Heart rate was recorded for 60 seconds and was observed in 96 hpf larvae using microscopy. The parameters were maintained as confidential ratio of 95%, threshold 0.01, G power 80% and enrolment ratio as 1. Result: It was observed that embryos exposed to an environment-relevant exposure dose showed reduced heart rate (41.05±1.30) compared to human exposure relevant dose (56.15± 1.47). There exists a statistically insignificant difference between the two groups (p=0.25). Conclusion: The current study results provide preliminary theoretical data revealing the impact of TCS on developing heart which has implications for pollutant-induced cardiac diseases in humans.
Factors Influencing Customer Grocery Shopping Behaviour Amid Covid-19 Pandemic
Authors: Rushi W.A. , Pradhan V.
Published: April 2023

Purpose: The paper attempts to understand and analyze the factors that influence different types of end consumer’s behavior while shopping for groceries both online and offline, considering the Covid-19 pandemic situations. Design/ Method/ Approach: A sample size of 145 members of age varying from 18 to 60 were surveyed through a digital form of a questionnaire. Few factors which generally impact the customer’s shopping behavior were categorized into six different factors: Purchase, Personal, Behavioral, Operational, Customer Engagement, and Pandemic factors. The respondents were asked to rank the elements according to their preferences. Findings: Factors like Quality of the Product, Hygiene practices followed by the delivery person, representation of products on website/application, Accessibility and Availability of the products were given priority amid pandemic, over other factors which influence customers shopping behavior. We have also found that FMCG advertisements that promise hygiene and safety during product delivery convinced the respondents, convinced the respondents. Practical Implications: The study gives an understanding of the factors influencing the retail customers amid the pandemic. This study can develop marketing strategies to target the middle-class and age group of 18-45.Originality/ Value: Factors influencing the customer’s decision to buy groceries online amid the Covid-19 pandemic induced consumer shopping behavior and preferences. Furthermore, the results show how the respondents were affected by the Hygiene promotions made by FMCG companies during the lockdown.
Analysis And Comparison Of Prediction Of Heart Disease Using Novel Random Forest And Naive Bayes Algorithm
Authors: Pavithraa G. , Sivaprasad S.
Published: April 2023

Aim : Prediction of heart disease using Novel Random Forest and comparing its accuracy with Naive Bayes algorithm. Materials and methods: Two groups are proposed for predicting the accuracy (%) of heart disease. Namely, the Novel Random Forest and Naive Bayes algorithm. Here we take 20 samples each for evaluation and compared. The sample size was calculated using G power with pretest power at 80% and the alpha of 0.05 value. Result : The Novel Random Forest gives better accuracy (86.40%) compared to the Naive Bayes accuracy (80.08%). Therefore the statistical significance of Novel Random Forest is better than Naive Bayes algorithm. Conclusion: From the result, it can be concluded that Novel Random Forest helps in predicting heart disease with more accuracy compared to Naive Bayes algorithm.
Analysis and Comparison of Image Enhancement Techniques for Improving PSNR of Liver Images by Linear Contrast Algorithm over Median Filtering
Authors: Prasad K.D. , Ramadevi R.
Published: April 2023

Aim: The goal of this research is to reduce noise present in the liver images in order to enhance it using linear contrast and median filters. And also to analyze output of both the filters based on its Peak Signal to Noise Ratio (PSNR). Materials and Methods: The research includes two groups; each group has a sample size of 20. Grayscale medical images collected from the kaggle website were used in this research. Samples were considered as (N=20) for guided filter and (N=20) for fast bilateral filter with total sample size 40 calculated using clinicalc.com. For this study, the affected and normal liver images were collected from the Kaggle website. Then the linear filtering, median filtering algorithms were executed using Matlab software. Sample size was calculated using clinicalc.com, and the comparison analysis has been carried out through SPSS software. This research contains two groups, with a Gpower of 80 percent. The performance of the novel median filter is evaluated and the performance measure PSNR is compared with the linear contrast filter. Result: Based on Matlab simulation results, the PSNR of novel median filters is 76.0355 and linear contrast filters have PSNR of 57.1785. From the statistical analysis, it is observed that the significant value of PSNR (Peak Signal to Noise Ratio) (0.409) and p>0.05. Conclusion: This study reveals that for the medical image enhancement purpose the novel median filter provides better PSNR than the linear contrast algorithm on ultrasound liver images.
Evaluation of minimum inhibitory concentration of methanol extract of cacao seeds on growth of Streptococcus mutans bacteria by microdilution method
Authors: Nuraskin Cut Aja , Faisal T. Iskandar , Reca  , Salfiyadi Teuku , Mardiah Ainun , Ahmad Arifin , Suhendra Rivansyah
Published: April 2023

Background: Indonesia is famous for its medicinal plants. Cocoa bean (Theobroma cacao L.) is a plant widely used as a traditional medicine alternative to cure diseases. Cocoa beans contain alkaloids, flavonoids, saponins and tannins which are antibacterial and have potential as antioxidants. Various dental and oral diseases that occur are caused by bacteria, one of which is Streptococcus mutans which causes dental caries. Bacteria that play an important role in the occurrence of dental caries is Streptococcus mutans. Dental caries can be prevented by chemically and mechanically maintaining oral hygiene using antiseptics that have antibacterial properties. This study aimed to test the minimum inhibitory concentration of methanol extract of cocoa seeds on the growth of Streptococcus mutans with the microdilution method.
Methods: The research method is the microdilution method with concentrations of 0.753%, 1.563%, 3.125%, 6.25%, 12.5%, 25%, 50%, 100%. Streptococcus mutans bacteria were obtained from the University of Indonesia's veterinary laboratory.
Results: The results showed that the minimum inhibitory concentration of methanol extract of cocoa beans on the growth of Streptococcus mutans was at a concentration of 1.563%.
Conclusions: In conclusion, the methanol extract of cocoa beans has an inhibitory effect on Streptococcus mutans bacteria and there is a minimum inhibitory concentration at a concentration of 1.563%. It is recommended to continue to toothpaste medication and do preclinical trials.
Analysis of fixed dose combinations of expectorants, antitussives, decongestants, antihistamines and mucolytics available in the Indian market for rationality and cost variation
Authors: Sathish Kumar B.  , Rohan A.  , Naveen Gowda B.
Published: April 2023

Background: Aim of the current study was to analyze the FDCs of expectorants, antitussives, decongestants, antihistamines and mucolytics available in the Indian market for their rationality, cost, and dosage forms.
Methods: FDCs involving expectorants, antitussives, decongestants, antihistamines and mucolytics listed on Drug Today and Jan Aushadhi online portal were analysed for rationality according to the list of banned FDCs by CDSCO published on 01 Jan 2018. The FDCs with EADAM available in Jan Aushadhi online portal are compared with cost of different brands with same composition, strength and dosage form available in the Indian market as per the latest drug today. The cost ratio and percentage cost variation were calculated for each FDC.
Results: Out of total 340 oral formulations, 268 were liquid and 72 were solid formulations. 228 were Syrups, 67 were Tablets, 23 were Drops, 17 were Suspension and 5 were Capsules. Out of 47 banned FDCs, branded FDC with Ammonium chloride 50mg, Bromhexine 4mg, Dextromethorphan 5mg and Menthol in syrup form was still available for over-the-counter purchase and for online purchase with prescription. Percentage cost variation between branded and generic FDCs ranged from 99% for Terbutaline 2.5 mg and Bromhexine 8 mg to 1081% for Terbutaline 1.25 mg, Bromhexine 4mg, Guaiphenesin 50 mg and Menthol 2.5 mg.
Conclusions: One among 47 Banned FDCs was available at both online apps and drug stores. These irrational FDCs can be risk to human lives. The drug authorities need to tune the price of these FDCs as there is a huge percentage cost variation between generic and branded products.
Teplizumab: a new glimmer of hope for type 1 diabetic patients
Authors: Garg Preeti , Sangeeta Bhanwra  , Rajiv Kumar
Published: April 2023

Teplizumab is the first monoclonal antibody used to delay the onset of stage 3 type 1 diabetes mellitus (DM). It is a highly selective, a CD3-directed monoclonal antibody, given parenterally that was approved in November 2022, for delaying the onset of Stage 3 type 1 diabetes in adults and paediatric patients aged 8 years and older with stage 2 type 1 Diabetes. It binds to the immune cells that destroy the insulin producing pancreatic beta cells and inactivates them thereby leading to decreased rate of reduction in insulin production and subsequently delay in the onset of stage 3 type 1 diabetes.
Lupus vulgaris on face: a case report
Authors: Nandakishore Thokchom , S. Mrudula , Kongbam Linda , Buchem Chai E. , Rokita Moirangthem , Anurag Srivastava
Published: April 2023

Lupus vulgaris is the most common form of cutaneous tuberculosis in adults. Starts either by re-infection or by lymphatic or hematogenous spread or by direct spread in individuals with moderate immunity and high degree of tuberculin sensitivity. Females affected 2-3 times more, constitute 1-2% of all extra-pulmonary TB. Common sites involved are face and neck. We reported a case lupus vulgaris in a 52 year old female patient.
Diagnosis and Treatment of Cauda Equina Arachnoiditis, a Rare Manifestation of Tuberculosis Meningoencephalitis: A Case Report
Authors: Kim Tae Yong , Kim Daehyun
Published: April 2023

Tuberculous meningoencephalitis (TM) is an acute, progressive form of tuberculosis (TB). The epidemiology, clinical signs, and diagnosis of TB are well established, but several atypical forms of tuberculous spinal arachnoiditis can be easily misdiagnosed. We report a rare case of TM with cauda equina arachnoiditis diagnosed by magnetic resonance imaging and an electrodiagnostic study. A 26-year-old otherwise healthy male patient experienced fever, headache, gait disturbance, and bladder and bowel incontinence. Needle electromyography (EMG) recordings were suggestive of bilateral diffuse lumbar and lumbosacral polyradiculopathy, and the pudendal sensory-evoked potential and bulbocavernosus reflex latencies were prolonged. Lumbar arachnoiditis is a rare clinical condition that warrants a heightened index of suspicion. It has diverse etiologies and symptoms, and it can lead to potentially serious and irreversible disorders. This case illustrates the usefulness of nerve conduction, EMG, and pudendal sensory-evoked potential and bulbocavernosus reflex latency studies in the diagnosis of cauda equina syndrome induced by TB arachnoiditis.
Inequalities in menstrual hygiene practices and social stigma among women of particular vulnerable tribal groups (PVTGs) in Madhya Pradesh
Authors: Kumar Dinesh , Saxena Nishant , Shrivastava Suyesh
Published: April 2023

This article aimed to understand the menstrual acquaintance, practices and hygiene care of underprivileged women living in difficult terrine. The PVTGs tribes have low literacy and poor socio-economic condition. The study has focused to find out the existing personnel health hygiene by way of the use of sanitary pad and fronting with social stigmas during the menstrual period.

Community based cross-sectional study was conducted in all three PVTGs Baiga, Bharia, and Saharia women of Madhya Pradesh. Data collection was done in 2019-20 in selected district Dindori, Chhindwara and Sheopur. A total 302 women were interviewed on menstrual hygiene practices and related issues who were in reproductive age (15-49 years). The related relevant information’s was collected by female trained investigators through structured questionnaire schedule by conducted interview method after obtained consent.

Care of menstrual hygiene as use of sanitary pad (absorbent) was found 11.2% among women. Inequality of the use of sanitary pad was seen lower (6%) in Baiga women in comparison considerably higher (17.6%) in Bharia and (10.4%) in Saharia women. Disposing the used absorbent at outside the village were found significantly higher (44.8%), (p<0.05) in Saharia while burn the used absorbent seen significantly higher (78.3%), (p<0.05) in Bharia women. Cleaning the genital with water only were found alarming 16.5% among women particularly 21% in Baiga,17.6% in Bharia and 11.5% in Saharia women due to different culture and norms. As regards 28% women feeling menstruation is Impure details as 42%, 9% and 31% by Baiga, Bharia and Saharia women. Restrictions as social stigma during menstrual period, about 13% of women were reported that they had not involved in the community social and cultural functions. Social stigma was seen noticeably higher (22%) among Saharia while lower (12.4%) in Bharia and 5% in Baiga community.

Use of hygiene absorbent during menstruation period was found comparatively very low (11.2%) among tribal women in comparison to national average. The tribal women are having greater risk of own health and her forthcoming baby. Appropriate IEC campaign program on awareness for menstrual hygiene care among women and easily availability of sanitary pad will be upholding of superior menstrual hygiene which correlated to health of mother and reproductive care.
Analysis of retinal arteriolar and venular parameters in primary open angle glaucoma
Authors:   Zhejiang University School of Medicine, Hang Zhou 310030, Zhejiang Province, China, Wang Jia-Peng , Xu Bo-Lun ,   Quzhou Central Hospital of Zhejiang Chinese Medical University, Quzhou People’s Hospital, Quzhou 324000, Zhejiang Province, China, Hua Jin-Ping ,   Quzhou Central Hospital of Zhejiang Chinese Medical University, Quzhou People’s Hospital, Quzhou 324000, Zhejiang Province, China, Jiang Li-Gang ,   Quzhou Central Hospital of Zhejiang Chinese Medical University, Quzhou People’s Hospital, Quzhou 324000, Zhejiang Province, China, Wang Jian-Tao ,   Shenzhen Eye Hospital, Jinan University, Shenzhen 518040, Guangdong Province, China, Yang Wei-Hua ,   Shenzhen Eye Hospital, Jinan University, Shenzhen 518040, Guangdong Province, China, Tong Yu-Hua ,   Quzhou Central Hospital of Zhejiang Chinese Medical University, Quzhou People’s Hospital, Quzhou 324000, Zhejiang Province, China
Published: April 2023

AIM: To measure the retinal vessels of primary open angle glaucoma (POAG) patients on spectral domain optical coherence tomography (SD-OCT) with a full-width at half-maximum (FWHM) algorithm to better explore their structural changes in the pathogenesis of POAG.
METHODS: In this retrospective case-control study, the right eyes of 32 patients with POAG and 30 healthy individuals were routinely selected. Images of the supratemporal and infratemporal retinal vessels in the B zones were obtained by SD-OCT, and the edges of the vessels were identified by the FWHM method. The internal and external diameters, wall thickness (WT), wall cross-sectional area (WCSA) and wall-to-lumen ratio (WLR) of the blood vessels were studied.
RESULTS: Compared with the healthy control group, the POAG group showed a significantly reduced retinal arteriolar outer diameter (RAOD), retinal arteriolar lumen diameter (RALD) and WSCA in the supratemporal (124.22±12.42 vs 138.32±10.73 µm, 96.09±11.09 vs 108.53±9.89 µm, and 4762.02±913.51 vs 5785.75±1148.28 µm2, respectively, all P<0.05) and infratemporal regions (125.01±15.55 vs 141.57±10.77 µm, 96.27±13.29 vs 110.83±10.99 µm, and 4925.56±1302.88 vs 6087.78±1061.55 µm2, all P<0.05). The arteriolar WT and WLR were not significantly different between the POAG and control groups, nor were the retinal venular outer diameter (RVOD), retinal venular lumen diameter (RVLD) or venular WT in the supratemporal or infratemporal region. There was a positive correlation between the arteriolar parameters and visual function.
CONCLUSION: In POAG, narrowing of the supratemporal and infratemporal arterioles and a significant reduction in the WSCA is observed, while the arteriolar WT and WLR do not change. Among the venular parameters, the external diameter, internal diameter, WT, WLR, and WSCA of the venules are not affected.
Flapless one-knot suture: a novel surgical technique for transscleral fixation of C-loop intraocular lenses
Authors:   Department of Ophthalmology, Gongli Hospital of Shanghai Pudong New Area, Shanghai 200135, China, Long Qing-Qing
Published: April 2023

AIM: To describe a novel suture approach for transscleral fixation of C-loop intraocular lenses (IOL) and to compare the surgical outcomes with the four-haptics posterior chamber (PC)-IOL technique.
METHODS: We retrospectively analyzed 16 eyes of 16 patients who underwent transscleral fixation of C-loop PC-IOLs using a flapless one-knot suture technique, which were followed up for longer than 17mo. In this technique, the capsulorless IOL was suspended using a single suture for transscleral fixation of four feet. Then we compared its surgical outcomes and complications with the four-haptics PC-IOLs using the Student’s t test and Chi-square test.
RESULTS: Sixteen patients of 16 eyes with a mean age of 58.3±10.1y (42-76y) who received transscleral C-loop IOL implantation due to trauma, vitrectomy, or cataract surgery with inadequate capsule support showed improved visual acuity. The difference was not significant between two IOLs except the surgery time (P>0.05). The mean operation times of C-loop IOL surgery was 24.1±1.83min and 31.3±4.47min of the four-haptics PC-IOL method (P<0.0001). In the C-loop IOLs group, there was statistical difference between the preoperative and the postoperative UCVA (logMAR, 1.20±0.50 vs 0.57±0.32, P=0.0003). There was no statistical difference between the preoperative and the postoperative BCVA (logMAR, 0.66±0.46 vs 0.40±0.23, P=0.056). However, there was no statistically significant difference in postoperative UCVA and BCVA between the two IOLs (P>0.05). We did not detect any optic capture, IOL decentration or dislocation, suture exposed, or cystoid macular edema in patients underwent C-loop IOLs surgery.
CONCLUSION: The novel flapless one-knot suture technique for transscleral fixation of C-loop IOL is a simple, reliable, and stable technique.
Ocular manifestations of children with atopic dermatitis in Saudi Arabia
Authors:   Department of Ophthalmology, King Abdulaziz University Hospital, Jeddah, Saudi Arabia; Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, Raffa Lina Hassan , Balbaid Nasser Talal ,   Department of Ophthalmology, King Abdulaziz University Hospital, Jeddah, Saudi Arabia, Zimmo Bader Sameer ,   Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Dermatology, King Abdulaziz University Hospital, Jeddah, Saudi Arabia, Showail Mahmood Jameel ,   Department of Ophthalmology, King Abdulaziz University Hospital, Jeddah, Saudi Arabia; Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
Published: April 2023

AIM: To examine the incidence of ocular abnormalities in children with atopic dermatitis (AD) in Saudi Arabia and its association with the severity of AD.
METHODS: This is a cross-sectional study on 50 children with AD who were between 5 and 16 years of age. The severity of AD was evaluated using the SCORing Atopic Dermatitis (SCORAD) index. All the children underwent slit lamp exams, visual acuity assessment, intraocular pressure measurement, and corneal topography. The children were considered to have an ophthalmic abnormality if one or more of the following signs were present: glaucoma, keratoconus suspicion, in addition to lid, conjunctival, corneal, lenticular, or retinal abnormalities.
RESULTS: Based on the SCORAD severity index, 14% of children had mild AD (7/50), 38% had moderate AD (19/50), and nearly half had severe AD. More than half the children exhibited facial involvement, and half had peri-orbital signs. The mean SCORAD index was 35.75. The mean age was 10.48±3.6y, and the cohort showed a slight male predominance (54% males). Both eyes of the 50 children in the cohort were studied. Based on the ocular examinations, 92% of the patients showed ocular abnormalities: lid abnormalities (27/50) followed by keratitis (22/50). Four patients had moderate risk for keratoconus in one eye and eight patients were suspected to have keratoconus. However, SCORAD severity index was not associated with age, sex, or the number or presence of ophthalmic abnormalities.
CONCLUSION: This is the first study in Saudi Arabia to evaluate the prevalence of ocular manifestations in children with AD. The results indicate that the majority of children with AD have ocular abnormalities that mainly include lid abnormalities. Based on these findings, larger scale studies are needed to affirm whether regular screening for ophthalmic abnormalities would be beneficial for children with AD in terms of early intervention and prevention of sight-threatening complications.
Publication trends of primary angle-closure disease during 1991-2022: a bibliometric analysis
Authors:   Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China, Huang Hai-Li , Wang Kai-Di ,   Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China, Sun Xing-Huai ,   Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China; NHC Key Laboratory of Myopia, Chinese Academy of Medical Sciences, and Shanghai Key Laboratory of Visual Impairment and Restoration (Fudan University), Shanghai 200031, China
Published: April 2023

AIM: To perform a bibliometric analysis in the field of primary angle-closure disease (PACD) research to characterize current global trends and compare contributions from different countries, institutions, journals, and authors.
METHODS: All PACD-related publications from 1991 to 2022 from the Web of Science Core Collection database were extracted. Microsoft Excel and VOSviewer were used to collect publication data, analyze publication trends, and visualize relevant results.
RESULTS: A total of 1721 publications with 34 591 citations were identified. China produced the most publications (554) while ranking third in citations (8220 times). The United States contributed the most citations (12 315 times) with publications (362) ranking second. The Investigative Ophthalmology Visual Science was the most productive journal concerning PACD, and Aung Tin was the author with the highest number of publications in the field. Keywords were classified into three clusters, epidemiology and pathogenesis research, optical coherence tomography (OCT) and other imaging examinations, and glaucoma surgery treatment. Genome-wide association, susceptibility loci, OCT, and combined phacoemulsification have become new hot research topics in recent years since 2015.
CONCLUSION: China, the United States, and Singapore make the most outstanding contributions in the field of PACD research. OCT, combined phacoemulsification, and gene mutation-related study, are considered the potential focus for future research.
Mitochondrial dysfunction in glaucomatous degeneration
Authors:   Affiliated Eye Hospital of Nanchang University, Nanchang University School of Ophthalmology & Optometry, Jiangxi Provincial Key Laboratory for Ophthalmology, Jiangxi Research Institute of Ophthalmology & Visual Science, Nanchang 330006, Jiangxi Province, China; Queen Mary School, Nanchang University, Nanchang 330006, Jiangxi Province, China, Zhang Zi-Qiao , Chen Sen-Yuan ,   Queen Mary School, Nanchang University, Nanchang 330006, Jiangxi Province, China, Zhang Xu ,   Affiliated Eye Hospital of Nanchang University, Nanchang University School of Ophthalmology & Optometry, Jiangxi Provincial Key Laboratory for Ophthalmology, Jiangxi Research Institute of Ophthalmology & Visual Science, Nanchang 330006, Jiangxi Province, China
Published: April 2023

Glaucoma is a kind of optic neuropathy mainly manifested in the permanent death of retinal ganglion cells (RGCs), atrophy of the optic nerve, and loss of visual ability. The main risk factors for glaucoma consist of the pathological elevation of intraocular pressure (IOP) and aging. Although the mechanism of glaucoma remains an open question, a theory related to mitochondrial dysfunction has been emerging in the last decade. Reactive oxygen species (ROS) from the mitochondrial respiratory chain are abnormally produced as a result of mitochondrial dysfunction. Oxidative stress takes place when the cellular antioxidant system fails to remove excessive ROS promptly. Meanwhile, more and more studies show that there are other common features of mitochondrial dysfunction in glaucoma, including damage of mitochondrial DNA (mtDNA), defective mitochondrial quality control, ATP reduction, and other cellular changes, which are worth summarizing and further exploring. The purpose of this review is to explore mitochondrial dysfunction in the mechanism of glaucomatous optic neuropathy. Based on the mechanism, the existing therapeutic options are summarized, including medications, gene therapy, and red-light therapy, which are promising to provide feasible neuroprotective ideas for the treatment of glaucoma.
Convolutional Neural Network-Based Classification Model of Corn Leaf Disease
Authors: Rachmad Aeri , Fuad Muhammad , Rochman Eka Mala Sari
Published: April 2023

The decline in corn production can affect the continuity of food grown in society, especially in Indonesia, which is a country with a high level of corn consumers. Several factors cause a decrease in the production of corn plants, one of which is unhealthy plants so that their growth slows down and even makes the corn plants not bear fruit or are damaged. Therefore, a system is needed that can identify diseases in corn plants so that appropriate treatment can be carried out as early as possible to prevent severe damage to corn plants. With this research, the system can be built by utilizing machine learning in building a classification system using the Convolutional Neural Network (CNN) algorithm with a dataset of corn leaf images taken from farmers' fields in the Madura Region with four target classes namely healthy, gray leaf spot, blight, and common rust. Testing was carried out using several CNN architectural models such as SqueezeNet, AlexNet, ResNet-101, ResNet-50, and ResNet-18. The parameters used were 5 epochs with 100 iterations, a learning rate of 0.0001, using Adam optimization, and a data distribution of 70% for training data and 30% for testing data. The test results obtained in classifying corn images using the Convolutional Neural Network method with the ResNet-50 architecture provide a very good accuracy value of 95.59%.
La planificación en el laberinto: un viaje hermenéutico
Authors: Onocko Campos Rosana
Published: April 2023

Es la intención de este trabajo crear un paréntesis, una pausa, un espacio de tiempo para la pregunta, para quedarnos en la aporía, pensando… ¿Se necesita de la planificación en salud? ¿Podríamos ser capaces de apoyar a grupos y equipos para enfrentar el futuro menos desarmados? ¿De dónde nos viene esta voluntad de tener una receta disponible? ¿Cuáles son las voces que nos hablan desde el pasado? ¿Cuáles son los rumbos que como seres humanos nos gustaría delinear? ¿Tenemos derecho a tener esta voluntad, sin caer en la manipulación tecnológica de nuestros semejantes? ¿O deberíamos conformarnos con un futuro abierto del cual seríamos meros testigos impotentes? O, tal vez, seamos capaces de divisar el futuro con esperanza, aceptándolo como incontrolable, aunque maleable, pasible de ser influenciado por la acción deliberada… Deliberada, racional y con voluntad. Toda voluntad tiene algo que ver con el deseo: pasión. Sin término medio. Espacio sin salida, aporía, laberinto. En busca del sentido de nuestras prácticas, del hilo que nos guíe en el laberinto sin salida, sumergimos en lecturas de textos nuevos y antiguos, oídos bien abiertos a las múltiples voces con que nos habla la tradición. En las páginas de este libro, algunos hallazgos por el camino.
История развития корпораций в России и за рубежом
Authors: Бахшян А.А. , Давудов Д.А.
Published: April 2023

Важнейшим элементом международных экономических отношений и развития мировой экономики в целом, кончено же, являются корпорации, и в начале XXI века все больше набирают обороты их развитие. Их стремительное распространение и развитие в последние десятилетия отражает процессы интернационализации производства и капитала, глобализации мирохозяйственных связей. Корпорации являются ключевым звеном и, непосредственным участником всех аспектов мирохозяйственных связей и своеобразными "локомотивами" мировой экономики. Корпорации играют важную роль в современной экономике, пополнение государственного бюджета, количество рабочих мест и другие важнейшие аспекты напрямую зависят от экономического успеха корпораций. Помимо этого, корпорации оказывают значительное влияние на образование и науку. Выбранная тема достаточно актуальна, поскольку важнейшей движущей силой глобализации мировой экономики являются корпорации. Корпорации в значительной степени способны определить политику многих государств мира, в случае возникновения разногласий, способны даже спровоцировать конфликты.
Некоторые вопросы привлечения к дисциплинарной ответственности государственных служащих
Authors: Зайченко А.О.
Published: April 2023

В статье исследовал вопрос о дисциплинарной ответственности государственных гражданских служащих в Российской Федерации. Дается определение дисциплинарной ответственности государственных служащих. Дисциплинарная ответственность рассматривается как принуждение, применяемое уполномоченными органами к совершившим дисциплинарный проступок лицам. Установлено, что привлечения государственного служащего к дисциплинарной ответственности является нарушение служебной дисциплины. Делается вывод о том, что современное российское государство заинтересовано в повышении престижа государственной службы, а одной из мер, направленных на совершенствование государственного управления, является развитие института дисциплинарной ответственности государственных служащих.
Особенности правого регулирования труда спортсменов и тренеров
Authors: Ильин В.В. , Петрова А.В.
Published: April 2023

В статье анализируются вопросы правового регулирования труда спортсменов и тренеров. Специфика применения трудового законодательства рассматривается в сочетании законодательного регулирования трудовых правоотношений данных субъектов и внутреннего регулирования спортивными федерациями.
Регистрация незаконных сделок с недвижимым имуществом: отдельные вопросы квалификации
Authors: Миташова А.А. , Синицына В.А. , Медведев С.С.
Published: April 2023

Российская Федерация, как и любое государство, заинтересовано в обеспечении развитой национальной экономики и защите ее от внешних и внутренних угроз. В этом направлении уголовная политика призвана для противодействия экономической преступности, профилактики совершения экономических преступлений, определения эффективных мер государственного принуждения к лицам, совершающих противоправные деяния. Все преступления в экономической деятельности посягают на различные конкретные общественные отношения. В частности, на право собственности на имущество, которые затрагивают интересы как физических, так и юридических лиц. С юридической стороны значимым является вопрос, связанный с регистрацией прав на движимое и недвижимое имущество.
К вопросу о присутствии лица с психическими расстройствами в зале суда при признании его недееспособным
Authors: Николаева Е.В.
Published: April 2023

В данной работе анализируются изменения в действующем законе о возможности присутствия гражданина в зале судебного заседания при разрешении дела о признании его недееспособным. Автором представлен обзор судебной практики об оценке способности душевнобольных находиться в зале суда при признании их недееспособными. Также представленысведения о зарубежном опыте и отечественных судебных процессах с учетом последних изменений действующего законодательства. Изучены современные методы оценки агрессивности лиц с психическими расстройствами. Предложены методы оценки возможности нахождения больных шизофренией в зале суда на основании симптомов их текущего состояния и их агрессивных действий в прошлом.
Совершенствование рецептуры вареных колбас с использованием растительных ингредиентов
Authors: Иванова Н.Н. , Костромкина Н.В. , Бардин А.В.
Published: April 2023

Для повышения экономической эффективности производства вареных колбас, не снижая их качество, целесообразно использовать растительное сырье, в частности, зеленый лук. При замене в рецептуре 6 % мясного фарша овощной добавкой прослеживалось торможение процессов окисления жиров. Все качественные показатели образца соответствовали требованиям на вареную колбасу.
Digital doubles in industry abroad
Authors: Smirnov S.V.
Published: April 2023

The article explores practical examples of the creation and application of digital doubles. Some effective strategies for obtaining value both at the tactical and strategic level are shown. Examples of the use of digital doubles by such companies as: Rolls-Royce, Mars, Bayer CropScience, Siemens are given. In addition, the application in China is presented.