bluuebunny/crossref_metadata_2025 huggingface dataset:
THREE TABLES FOR BOB
Authors: Sabat Marc
Published: September 2016

To distinguish differences of harmony, to compose music so that players and listeners may sense these variations naturally, in real time, the representation of harmonic space in musical notation must be precise yet simple to read. Shadings of intonation are most clearly conceived in relation to consonant, untempered intervals. Intervals derived from a common frame of reference may be represented by microtonal signs, which suggest potentially tuneable intervallic relationships.
ART BEGINS WHERE CRAFTSMANSHIP ENDS
Authors: Volans Kevin
Published: September 2016

In the last few months of his life, Bob Gilmore embarked on another major project: that of writing a book about my work. He pressed me to try to define what I meant by non-conceptual composition and composition as an art form. This is a condensation of some of the topics we talked about for many hours.
‘New Blood’: 130701, 15th Anniversary Showcase, Brighton Festival
Authors: Nicolls Sarah
Published: September 2016

The Spire, St Mark's chapel, is an artist-led creation space in Brighton. Normally it's a blank space without heating or equipment but for the night of 10 May it is fantastically dressed up with lights, pictures and a projection saying ‘landmark post-classical recordings’. This is a label showcase for 130701, an offshoot of FatCat Records set up by Dave Howell in 2001. Hauschka, one of the label's longstanding artists who has opened up his imaginative and playful inside-piano playing to commercial audiences, and the label's willingness to support live experimental music are the reasons I'm here.
Christian Wolff Wade in the Water, Kammer Klang, Café Oto, London
Authors: Fox Christopher
Published: September 2016

Is there any London concert venue more suited to the music of Christian Wolff than Café Oto? It's not so much its status as the nexus of hipster lounge and ascetic experimentalism as its noisiness. No sooner had violinist Aisha Orazbayeva and pianist Joseph Houston begun to play Wolff's indeterminate classic For 1, 2 or 3 People (1964) than I was reminded of John Cage:

One day when the windows were open, Christian Wolff played one of his pieces at the piano. Sounds of traffic, boat horns … were more easily heard than the piano sounds themselves. Afterward, someone asked Christian Wolff to play the piece again with the windows closed. Christian Wolff said … it wasn't really necessary, since the sounds of the environment were in no sense an interruption of those of the music.
Philip Venables 4.48 Psychosis, Royal Opera House at Lyric Hammersmith, London; Liza Lim Tree of Codes, Musikfabrik, Cologne Opera, Cologne
Authors: Rutherford-Johnson Tim
Published: September 2016

As the first Doctoral Composer-in-Residence of the Royal Opera House and Guildhall School of Music and Drama, Philip Venables has – some might say bravely – chosen to adapt 4.48 Psychosis, the last play by the late British playwright Sarah Kane. Brave for several reasons. Kane's work is renowned for its naked, sometimes brutal, expression and themes, and the nihilism and violence of her plays have caused critical uproar in the past. Moreover, her estate has until now been understandably protective of her legacy; Venables's opera, premiered in May, is the first adaptation they have permitted, and came with instructions to remain as true as possible to the text.
Borealis Festival, Bergen
Authors: Gottschalk Kurt
Published: September 2016

It wouldn't be the worst idea if Anthony Braxton's Composition No. 58 were used to kick off every music festival. In any event, it's hard to think of a fanfare more fitting for the common fan, whether of classical, jazz or experimental rock. It could, for example, quite easily be followed by a piece of Mauricio Kagel's instrumental theatre or a parade by the Sun Ra Arkestra or the precisely played experimental excursions of the Brooklyn avant-rock outfit Zs.
Risk factors related to the admission of people with dementia into a long-term care institution in Spain: an explorative study
Authors: RISCO ESTER , CABRERA ESTHER , ALVIRA M. CARME , FARRÉ MARTA , MIGUEL SUSANA , ZABALEGUI ADELAIDA
Published: September 2016

Risk factors associated with admission of people with dementia to long-term care institutions need to be identified to support health-care professionals in dementia care at home. An explorative study, combining quantitative and qualitative data collection methods, was performed in people with dementia in Spain. The sample, consisting of people with dementia receiving formal care from health-care professionals but at risk of institutionalisation, and their informal care-givers; and people with dementia recently admitted to a long-term care institution, and their informal care-givers, was interviewed between November 2010 and April 2012. Perceived reasons for admission were determined through an open-ended question put to both groups. Presumed risk factors were collected with validated questionnaires and analysed using bivariate analysis. A total of 287 people with dementia and informal care-givers were studied. Reasons given by the institutionalised group were mostly related to the level of dependency of the person with dementia. People recently admitted to a long-term care institution had more cognitive impairment, a greater degree of dependency and poorer quality of life than those still living at home. Home-care services in Spain need to develop or improve interventions based on the risk factors identified in this study: informal care-giver profile, high cognitive impairment, high level of dependency and the poor quality of life of the person with dementia.
A MUSIC BOOK FOR MARY TUDOR, QUEEN OF FRANCE
Authors: Brobeck John T.
Published: September 2016

Frank Dobbins in memoriam

In 1976 Louise Litterick proposed that Cambridge, Magdalene College, Pepys Library MS 1760 was originally prepared for Louis XII and Anne of Brittany of France but was gifted to Henry VIII of England in 1509. That the manuscript actually was prepared as a wedding gift from Louis to his third wife Mary Tudor in 1514, however, is indicated by its decorative and textual imagery, which mirrors the decoration of a book of hours given by Louis to Mary and the textual imagery used in her four royal entries. Analysis of the manuscript’s tabula and texts suggests that MS 1760 was planned by Louis’s chapelmaster Hilaire Bernonneau (d. 1524) at the king’s behest. The new theory elucidates the content and significance of Gascongne’s twelve-voice canon Ista est speciosa, which appeared beneath an original portrait of Mary Tudor and was intended to mirror the perfection of the Blessed Virgin and her ‘godchild’ Mary.
‘YONG BEGINNERS, WHO LIVE IN THE COUNTREY’: JOHN PLAYFORD AND THE PRINTED MUSIC MARKET IN SEVENTEENTH-CENTURY ENGLAND
Authors: Carter Stephanie
Published: September 2016

John Playford dominated the commercial music publishing trade of mid-seventeenth-century England, encouraging musical literacy and supplying beginner books for the growing domestic amateur musical class. Playford was clearly aware of the need to attract as many customers as possible in order to succeed in a commercial business; however, very little is known about his customers. This article identifies the contemporary audiences of seventeenth-century English printed music books, building on previous scholarship including Alec Hyatt King’sSome British Collectors of Music c. 1600–1900(1963), and provides an initial record of provenance marks in surviving copies of the publications. Placing the printed book and its customer within the wider context of music-making and bookselling in seventeenth-century England develops our understanding of the social dimensions of the printed music trade, including dissemination and distribution networks.
THE FEAST OF THE SEVEN SORROWS OF THE VIRGIN: PIETY, POLITICS AND PLAINCHANT AT THE BURGUNDIAN-HABSBURG COURT
Authors: Thelen Emily S.
Published: September 2016

Devotion to the Virgin of Seven Sorrows flourished in the Low Countries in the late fifteenth century during a period of recovery from civil war, famine and economic instability. The Burgundian-Habsburg court took a special interest in this popular lay movement and, in an unusual move, sponsored a competition to generate a liturgy – a plainchant office and mass – for the growing devotion. This article identifies new sources for the text and music of the Seven Sorrows liturgy and ties them to the court’s competition. An examination of the surviving office and mass demonstrates the texts’ dependence on an earlier Marian celebration of the Compassion of the Virgin. The reworking of this older devotion reveals that the plainchant competition and the creation of the new Seven Sorrows liturgy were part of the court’s political agenda of restoring peace and unity to their territories.
Virtual Electronic Aids to Navigation for Remote and Ecologically Sensitive Regions
Authors: Wright R. Glenn , Baldauf Michael
Published: September 2016

Vessel traffic in the Arctic is expanding in volume both within and transiting the region, yet the infrastructure necessary to support modern ship navigation is lacking. This includes aids to navigation such as buoys and beacons that can be difficult to place and maintain in this hostile environment that stretches across vast distances. The results of research are described which determine whether virtual electronic Aids to Navigation (eAtoN) existing entirely as digital information objects can overcome the practical limitations of physical aids to navigation (AtoN) and Automatic Identification System (AIS) radio eAtoN. Capabilities unique to virtual eAtoN that are not available using either physical or AIS radio technologies are also examined including dynamic and real time properties and immunity to Global Navigation Satellite System (GNSS) and AIS spoofing, aliasing, denial of service attacks and service outages. Conclusions are provided describing potential methods of deployment based upon similar concepts already in use.
Robust Adaptive Kalman Filtering – a method based on quasi-accurate detection and plant noise variance–covariance matrix tuning
Authors: Luo Xiaowen , Wang Haitao
Published: September 2016

In this paper, we propose an algorithm for tuning both the kinematic and measurement noise Variance–Covariance (VCV) matrices to produce a more robust and adaptive Kalman filter. The proposed algorithm simultaneously considers both observation outliers and abrupt changes. This algorithm may be divided into two basic parts: 1. Robust estimation, from which the position components of the filtering estimates and the equivalent weight factor matrix can be obtained; and 2. Adaptive estimation, from which the adaptive kinematic noise VCV tuning matrix is calculated. To demonstrate the efficiency of our algorithm, we process a set of kinematic Global Positioning System (GPS) data received from a rover mounted on an aeroplane. The processing results are found to be very satisfactory, with observation outliers and abrupt changes detected and dealt with accordingly. The detailed calculation procedure for the adaptive VCV tuning matrix is also described.
Multiple Model Adaptive Rank Estimation for Integrated Navigation During Mars Entry
Authors: Xiao Qiang , Fu Huimin , Wang Zhihua , Zhang Yongbo
Published: September 2016

Accurate navigation systems are required for future pinpoint Mars landing missions. A radio ranging augmented Inertial Measurement Unit (IMU) integrated navigation system concept is considered for the Mars entry navigation. The uncertain system parameters associated with the Three Degree-Of-Freedom (3-DOF) dynamic model, and the measurement systematic errors are considered. In order to improve entry navigation accuracy, this paper presents the Multiple Model Adaptive Rank Estimation (MMARE) filter of radio beacons/IMU integrated navigation system. 3-DOF simulation results show that the performances of the proposed navigation filter method, 70·39 m estimated altitude error and 15·74 m/s estimated velocity error, fulfill the need of future pinpoint Mars landing missions.
Curvature determination of embedded silicon chips byin siturocking curve X-ray diffraction measurements at elevated temperatures
Authors: Angerer Paul , Schöngrundner Ronald , Macurova Katerina , Wiessner Manfred , Keckes Jozef
Published: September 2016

The deflection (curvature) of embedded single-crystal silicon chips was investigated by rocking curve X-ray diffraction techniques at two significant manufacturing stages in the process chain of printed circuit boards with embedded components. An overview of the curvature deduction by two different approaches was presented: (1) the measurement of the variation of the rocking curve maximum as a function of the lateral sample position along a specific traverse; the slope in such a diagram is then proportional to the corresponding curvature in that direction. (2) The evaluation of the rocking curve width; here the peak width is inversely proportional to the curvature at known beam diameter, diffraction angle, and beam divergence. It was shown that the rocking curve method is applicable to determine the curvature inside single crystalline chips. Furthermore, the method is also suitable to determine the curvature of fully embedded or encapsulated chips. Additionally the absorption of the radiation in the embed medium was quantitatively discussed. The curvature of two different prepared samples was determined at temperatures up to 200 °C in a heating stage attached to the diffractometer device.
Age-specific mixing generates transient outbreak risk following critical-level vaccination
Authors: BHATTACHARYYA S. , FERRARI M. J.
Published: September 2016

Measles elimination goals have been adopted in a range of countries, sub-regions, and regions since the WHO declared an elimination goal by 2015 or 2020. All countries attempt to achieve and maintain high coverage through routine immunization programmes. This routine strategy, however, does not ensure the elimination goal of measles. Many developed countries, such as the United States, that have succeeded in interrupting measles transmission earlier, are now experiencing outbreaks with an increasing number of cases. Using a stochastic, age-structured model of measles vaccination dynamics, we explore and characterize the transient dynamics of measles susceptibility in the years following the implementation of routine vaccination at the herd immunity threshold. We demonstrate how a population could face risks of potentially large outbreaks even within few years of vaccination. We characterize different risk profiles depending on the incidence pattern in the years prior to vaccination. These results suggest that the classic critical vaccination threshold is necessary to achieve herd immunity, but not sufficient to prevent long periods of transient, super-critical dynamics. Our results suggest the need of future work for more careful monitoring of the impacts of current immunization programmes, and developing models that take into account more complicated vaccination strategies, demographic factors, and population movements.
Risk factors for acute toxoplasmosis in England and Wales
Authors: SAID B. , HALSBY K. D. , O'CONNOR C. M. , FRANCIS J. , HEWITT K. , VERLANDER N. Q. , GUY E. , MORGAN D.
Published: September 2016

Over 300 cases of acute toxoplasmosis are confirmed by reference testing in England and Wales annually. We conducted a case-control study to identify risk factors for Toxoplasma gondii infection to inform prevention strategies. Twenty-eight cases and 27 seronegative controls participated. We compared their food history and environmental exposures using logistic regression to calculate odds ratios (OR) and 95% confidence intervals in a model controlling for age and sex. Univariable analysis showed that the odds of eating beef (OR 10·7, P < 0·001), poultry (OR 6·4, P = 0·01) or lamb/mutton (OR 4·9, P = 0·01) was higher for cases than controls. After adjustment for potential confounders a strong association between beef and infection remained (OR 5·6, P = 0·01). The small sample size was a significant limitation and larger studies are needed to fully investigate potential risk factors. The study findings emphasize the need to ensure food is thoroughly cooked and handled hygienically, especially for those in vulnerable groups.
AGING AND FISCAL SUSTAINABILITY IN A SMALL EURO AREA ECONOMY
Authors: Castro Gabriela , Maria José R. , Félix Ricardo Mourinho , Braz Cláudia Rodrigues
Published: September 2016

Economic and social impacts of aging trends will be of the utmost importance in the near future. We embed a stylized pay-as-you-go (PAYG) pension system into a DSGE model with overlapping generations to assess the macroeconomic effects of aging in a small Euro Area economy. The simulations suggest large negative impacts on GDP and private consumption. In addition, external imbalances may widen significantly under the PAYG system. All results are conditional on the policy options addressing debt sustainability–the impacts tend to be very large if the government finances the aging with higher social security premia instead of lower replacement ratios. Sensitivity analysis reveals that GDP and private consumption impacts are less robust than those on external imbalances. Results also imply that supranational policy coordination may be crucial if the objective is to preserve economic and financial stability in the Euro Area.
CHINA'S ROLE IN GLOBAL INFLATION DYNAMICS
Authors: Eickmeier Sandra , Kühnlenz Markus
Published: September 2016

We apply a structural dynamic factor model to a large quarterly data set covering 38 countries between 2002 and 2011 to analyze China's role in global inflation dynamics. We identify Chinese supply and demand shocks and examine their contributions to global price dynamics and the transmission mechanism. Our main findings are as follows: (i) Chinese supply and demand shocks affect prices in other countries significantly. Demand shocks matter slightly more than supply shocks. Producer prices tend to be more strongly affected than consumer prices by Chinese shocks. The overall share of international inflation explained by Chinese shocks is notable (about 6 percent on the average over all countries but not more than 13 percent in each region). (ii) Direct channels (via import and export prices) and indirect channels (via greater exposure to foreign competition and commodity prices) both matter. (iii) Differences in trade and in commodity exposure help explain cross-country differences in price responses.
UNEMPLOYMENT PERSISTENCE AND QUANTILE PARAMETER HETEROGENEITY
Authors: Andini Corrado , Andini Monica
Published: September 2016

We argue that a random-coefficients representation of the classical Barro's model of unemployment dynamics can be used as a theoretical basis for a panel quantile autoregressive model of the unemployment rate. Estimating the latter with State-level data for the United States (1980–2010), we find that (i) unemployment persistence increases along quantiles of the conditional unemployment distribution; (ii) disregarding State-fixed effects implies an overestimation of unemployment persistence along unemployment quantiles; (iii) a macroeconomic shock changes not only the location but also the dispersion of the distribution of the State unemployment rates; (iv) a federal policy equally applied in each State can reduce unemployment inequality among States; (v) “hysteresis” and “natural rate” hypotheses can co-exist along quantiles of the unemployment distribution, with the former being not rejected at upper quantiles. In sum, while the standard approach to the estimation of unemployment persistence implicitly assumes that quantile parameter heterogeneity does not matter, we suggest that it does.
Sustainably powering wearable electronics solely by biomechanical energy
Authors: Wang Jie , Li Shengming , Yi Fang , Zi Yunlong , Lin Jun , Wang Xiaofeng , Xu Youlong , Wang Zhong Lin
Published: September 2016

Harvesting biomechanical energy is an important route for providing electricity to sustainably drive wearable electronics, which currently still use batteries and therefore need to be charged or replaced/disposed frequently. Here we report an approach that can continuously power wearable electronics only by human motion, realized through a triboelectric nanogenerator (TENG) with optimized materials and structural design. Fabricated by elastomeric materials and a helix inner electrode sticking on a tube with the dielectric layer and outer electrode, the TENG has desirable features including flexibility, stretchability, isotropy, weavability, water-resistance and a high surface charge density of 250 μC m−2. With only the energy extracted from walking or jogging by the TENG that is built in outsoles, wearable electronics such as an electronic watch and fitness tracker can be immediately and continuously powered.
Robust upward dispersion of the neutron spin resonance in the heavy fermion superconductor Ce1−xYbxCoIn5
Authors: Song Yu , Van Dyke John , Lum I. K. , White B. D. , Jang Sooyoung , Yazici Duygu , Shu L. , Schneidewind A. , Čermák Petr , Qiu Y. , Maple M. B. , Morr Dirk K. , Dai Pengcheng
Published: September 2016

The neutron spin resonance is a collective magnetic excitation that appears in the unconventional copper oxide, iron pnictide and heavy fermion superconductors. Although the resonance is commonly associated with a spin-exciton due to the d(s±)-wave symmetry of the superconducting order parameter, it has also been proposed to be a magnon-like excitation appearing in the superconducting state. Here we use inelastic neutron scattering to demonstrate that the resonance in the heavy fermion superconductor Ce1−xYbxCoIn5 with x=0, 0.05 and 0.3 has a ring-like upward dispersion that is robust against Yb-doping. By comparing our experimental data with a random phase approximation calculation using the electronic structure and the momentum dependence of the "Equation missing"-wave superconducting gap determined from scanning tunnelling microscopy (STM) for CeCoIn5, we conclude that the robust upward-dispersing resonance mode in Ce1−xYbxCoIn5 is inconsistent with the downward dispersion predicted within the spin-exciton scenario.
Raman gas self-organizing into deep nano-trap lattice
Authors: Alharbi M. , Husakou A. , Chafer M. , Debord B. , Gérôme F. , Benabid F.
Published: September 2016

Trapping or cooling molecules has rallied a long-standing effort for its impact in exploring new frontiers in physics and in finding new phase of matter for quantum technologies. Here we demonstrate a system for light-trapping molecules and stimulated Raman scattering based on optically self-nanostructured molecular hydrogen in hollow-core photonic crystal fibre. A lattice is formed by a periodic and ultra-deep potential caused by a spatially modulated Raman saturation, where Raman-active molecules are strongly localized in a one-dimensional array of nanometre-wide sections. Only these trapped molecules participate in stimulated Raman scattering, generating high-power forward and backward Stokes continuous-wave laser radiation in the Lamb–Dicke regime with sub-Doppler emission spectrum. The spectrum exhibits a central line with a sub-recoil linewidth as low as ∼14 kHz, more than five orders of magnitude narrower than conventional-Raman pressure-broadened linewidth, and sidebands comprising Mollow triplet, motional sidebands and four-wave mixing.
Unexpected functional implication of a stable succinimide in the structural stability of Methanocaldococcus jannaschii glutaminase
Authors: Kumar Sanjeev , Prakash Sunita , Gupta Kallol , Dongre Aparna , Balaram Padmanabhan , Balaram Hemalatha
Published: September 2016

Protein ageing is often mediated by the formation of succinimide intermediates. These short-lived intermediates derive from asparaginyl deamidation and aspartyl dehydration and are rapidly converted into β-aspartyl or D-aspartyl residues. Here we report the presence of a highly stable succinimide intermediate in the glutaminase subunit of GMP synthetase from the hyperthermophile Methanocaldoccocus jannaschii. By comparing the biophysical properties of the wild-type protein and of several mutants, we show that the presence of succinimide increases the structural stability of the glutaminase subunit. The protein bearing this modification in fact remains folded at 100 °C and in 8 M guanidinium chloride. Mutation of the residue following the reactive asparagine provides insight into the factors that contribute to the hydrolytic stability of the succinimide. Our findings suggest that sequences that stabilize succinimides from hydrolysis may be evolutionarily selected to confer extreme thermal stability.
Forward design of a complex enzyme cascade reaction
Authors: Hold Christoph , Billerbeck Sonja , Panke Sven
Published: September 2016

Enzymatic reaction networks are unique in that one can operate a large number of reactions under the same set of conditions concomitantly in one pot, but the nonlinear kinetics of the enzymes and the resulting system complexity have so far defeated rational design processes for the construction of such complex cascade reactions. Here we demonstrate the forward design of an in vitro 10-membered system using enzymes from highly regulated biological processes such as glycolysis. For this, we adapt the characterization of the biochemical system to the needs of classical engineering systems theory: we combine online mass spectrometry and continuous system operation to apply standard system theory input functions and to use the detailed dynamic system responses to parameterize a model of sufficient quality for forward design. This allows the facile optimization of a 10-enzyme cascade reaction for fine chemical production purposes.
Divergence of cuticular hydrocarbons in two sympatric grasshopper species and the evolution of fatty acid synthases and elongases across insects
Authors: Finck Jonas , Berdan Emma L. , Mayer Frieder , Ronacher Bernhard , Geiselhardt Sven
Published: September 2016

Cuticular hydrocarbons (CHCs) play a major role in the evolution of reproductive isolation between insect species. The CHC profiles of two closely related sympatric grasshopper species,Chorthippus biguttulusandC. mollis, differ mainly in the position of the first methyl group in major methyl-branched CHCs. The position of methyl branches is determined either by a fatty acid synthase (FAS) or by elongases. Both protein families showed an expansion in insects. Interestingly, the FAS family showed several lineage-specific expansions, especially in insect orders with highly diverse methyl-branched CHC profiles. We found five putative FASs and 12 putative elongases in the reference transcriptomes for both species. A dN/dS test showed no evidence for positive selection acting on FASs and elongases in these grasshoppers. However, one candidate FAS showed species-specific transcriptional differences and may contribute to the shift of the methyl-branch position between the species. In addition, transcript levels of four elongases were expressed differentially between the sexes. Our study indicates that complex methyl-branched CHC profiles are linked to an expansion of FASs genes, but that species differences can also mediated at the transcriptional level.
Efficient delivery of C/EBP beta gene into human mesenchymal stem cells via polyethylenimine-coated gold nanoparticles enhances adipogenic differentiation
Authors: Das Joydeep , Choi Yun-Jung , Yasuda Hideyo , Han Jae Woong , Park Chankyu , Song Hyuk , Bae Hojae , Kim Jin-Hoi
Published: September 2016

The controlled differentiation of stem cells via the delivery of specific genes encoding appropriate differentiation factors may provide useful models for regenerative medicine and aid in developing therapies for human patients. However, the majority of non-viral vectors are not efficient enough to manipulate difficult-to-transfect adult human stem cells in vitro. Herein, we report the first use of 25 kDa branched polyethylenimine-entrapped gold nanoparticles (AuPEINPs) and covalently bound polyethylenimine-gold nanoparticles (AuMUAPEINPs) as carriers for efficient gene delivery into human mesenchymal stem cells (hMSCs). We determined a functional application of these nanoparticles by transfecting hMSCs with the C/EBP beta gene, fused to EGFP, to induce adipogenic differentiation. Transfection efficacy with AuPEINPs and AuMUAPEINPs was 52.3% and 40.7%, respectively, which was 2.48 and 1.93 times higher than that by using Lipofectamine 2000. Luciferase assay results also demonstrated improved gene transfection efficiency of AuPEINPs/AuMUAPEINPs over Lipofectamine 2000 and polyethylenimine. Overexpression of exogenous C/EBP beta significantly enhanced adipogenesis in hMSCs as indicated by both of Oil Red O staining and mRNA expression analyses. Nanoparticle/DNA complexes exhibited favorable cytocompatibility in hMSCs. Taken together, AuPEINPs and AuMUAPEINPs potentially represent safe and highly efficient vehicles for gene delivery to control hMSC differentiation and for therapeutic gene delivery applications.
Realizing topological stability of magnetic helices in exchange-coupled multilayers for all-spin-based system
Authors: Fust Sergej , Mukherjee Saumya , Paul Neelima , Stahn Jochen , Kreuzpaintner Wolfgang , Böni Peter , Paul Amitesh
Published: September 2016

Topologically stabilized spin configurations like helices in the form of planar domain walls (DWs) or vortex-like structures with magnetic functionalities are more often a theoretical prediction rather than experimental realization. In this paper we report on the exchange coupling and helical phase characteristics within Dy-Fe multilayers. The magnetic hysteresis loops with temperature show an exchange bias field of around 1.0 kOe at 10 K. Polarized neutron reflectivity reveal (i) ferrimagnetic alignment of the layers at low fields forming twisted magnetic helices and a more complicated but stable continuous helical arrangement at higher fields (ii) direct evidence of helices in the form of planar 2π-DWs within both layers of Fe and Dy. The helices within the Fe layers are topologically stabilized by the reasonably strong induced in-plane magnetocrystalline anisotropy of Dy and the exchange coupling at the Fe-Dy interfaces. The helices in Dy are plausibly reminiscent of the helical ordering at higher temperatures induced by the field history and interfacial strain. Stability of the helical order even at large fields have resulted in an effective modulation of the periodicity of the spin-density like waves and subsequent increase in storage energy. This opens broad perspectives for future scientific and technological applications in increasing the energy density for systems in the field of all-spin-based engineering which has the potential for energy-storing elements on nanometer length scales.
Characterization and Potential Applications of a Selenium Nanoparticle Producing and Nitrate Reducing Bacterium Bacillus oryziterrae sp. nov.
Authors: Bao Peng , Xiao Ke-Qing , Wang Hui-Jiao , Xu Hao , Xu Peng-Peng , Jia Yan , Häggblom Max M. , Zhu Yong-Guan
Published: September 2016

A novel nitrate- and selenite reducing bacterium strain ZYKT was isolated from a rice paddy soil in Dehong, Yunnan, China. Strain ZYKT is a facultative anaerobe and grows in up to 150, 000 ppm O2. The comparative genomics analysis of strain ZYKT implies that it shares more orthologues with B. subtilis subsp. subtilis NCIB 3610T (ANIm values, 85.4–86.7%) than with B. azotoformans NBRC 15712T (ANIm values, 84.4–84.7%), although B. azotoformans NBRC 15712T (96.3% 16S rRNA gene sequence similarity) is the closest Bacillus species according to 16S rRNA gene comparison. The major cellular fatty acids of strain ZYKT were iso-C14:0 (17.8%), iso-C15:0 (17.8%), and C16:0 (32.0%). The polar lipid profile consisted of phosphatidylethanolamine, diphosphatidylglycerol, phosphatidylglycerol and an unidentified aminophospholipid. Based on physiological, biochemical and genotypic properties, the strain was considered to represent a novel species of the genus Bacillus, for which the name Bacillus oryziterrae sp. nov. is proposed. The type strain is ZYKT (=DSM 26460T =CGMCC 1.5179T). Strain ZYKT can reduce nitrate to nitrite and ammonium and possesses metabolic genes for nitrate reduction including nar, nap and nrf. Biogenic selenium nanoparticles of strain ZYKT show a narrow size distribution and agree with the gaussian distribution. These selenium nanoparticles show significant dose-dependent inhibition of the lung cancer cell line H157, which suggests potential for application in cancer therapy.
Rolling behavior of a micro-cylinder in adhesional contact
Authors: Saito Shigeki , Ochiai Toshihiro , Yoshizawa Fumikazu , Dao Ming
Published: September 2016

Understanding the rolling behavior of a micro-object is essential to establish the techniques of micro-manipulation and micro-assembly by mechanical means. Using a combined theoretical/computational approach, we studied the critical conditions of rolling resistance of an elastic cylindrical micro-object in adhesional contact with a rigid surface. Closed-form dimensionless expressions for the critical rolling moment, the initial rolling contact area and the initial rolling angle were extracted after a systematic parametric study using finite element method (FEM) simulations. The total energy of this system is defined as the sum of three terms: the elastic energy stored in the deformed micro-cylinder, the interfacial energy within the contact area and the mechanical potential energy that depends on the external moment applied to the cylindrical micro-object. A careful examination of the energy balance of the system surprisingly revealed that the rolling resistance per unit cylindrical length can be simply expressed by “work of adhesion times cylindrical radius” independent of the Young’s modulus. In addition, extending a linear elastic fracture mechanics based approach in the literature, we obtained the exact closed-form asymptotic solutions for the critical conditions for initial rolling; these asymptotic solutions were found in excellent agreement with the full-field FEM results.
Demographic and reproductive plasticity across the depth distribution of a coral reef fish
Authors: Goldstein Esther D. , D’Alessandro Evan K. , Sponaugle Su
Published: September 2016

As humans expand into natural environments, populations of wild organisms may become relegated to marginal habitats at the boundaries of their distributions. In the ocean, mesophotic coral ecosystems (30–150 m) at the depth limit of photosynthetic reefs are hypothesized to act as refuges that are buffered from anthropogenic and natural disturbances, yet the viability and persistence of subpopulations in these peripheral habitats remains poorly understood. To assess the potential for mesophotic reefs to support robust coral reef fish populations, we compared population density and structure, growth, size, and reproductive output of the bicolor damselfish (Stegastes partitus) from shallow (<10 m), deep shelf (20–30 m), and mesophotic reefs (60–70 m) across the Florida Platform. Population densities decreased and size and age distributions shifted toward older and larger individuals in deeper habitats. Otolith-derived ages indicated that S. partitus found on mesophotic reefs reach larger asymptotic sizes and have longer lifespans than fish in shallower habitats. Based on measurements of oocyte area and batch fecundity, mesophotic fish also have higher reproductive investment. These demographic patterns indicate that mesophotic fish populations composed of large, fecund individuals produce high condition larvae and rely on longevity of individuals for population persistence and viability.
A natural Anopheles-associated Penicillium chrysogenum enhances mosquito susceptibility to Plasmodium infection
Authors: Angleró-Rodríguez Yesseinia I. , Blumberg Benjamin J. , Dong Yuemei , Sandiford Simone L. , Pike Andrew , Clayton April M. , Dimopoulos George
Published: September 2016

Whereas studies have extensively examined the ability of bacteria to influence Plasmodium infection in the mosquito, the tripartite interactions between non-entomopathogenic fungi, mosquitoes and Plasmodium parasites remain largely uncharacterized. Here we report the isolation of a common mosquito-associated ascomycete fungus, Penicillium chrysogenum, from the midgut of field-caught Anopheles mosquitoes. Although the presence of Pe. chrysogenum in the Anopheles gambiae midgut does not affect mosquito survival, it renders the mosquito significantly more susceptible to Plasmodium infection through a secreted heat-stable factor. We further provide evidence that the mechanism of the fungus-mediated modulation of mosquito susceptibility to Plasmodium involves an upregulation of the insect’s ornithine decarboxylase gene, which sequesters arginine for polyamine biosynthesis. Arginine plays an important role in the mosquito’s anti-Plasmodium defense as a substrate of nitric oxide production and its availability therefore has a direct impact on the mosquito’s susceptibility to the parasite. While this type of immunomodulatory mechanism has already been demonstrated in other host-pathogen interaction systems, this is the first report of a mosquito-associated fungus that can suppress the mosquito’s innate immune system in a way that would favor Plasmodium infection and possibly malaria transmission.
Near-infrared roll-off-free electroluminescence from highly stable diketopyrrolopyrrole light emitting diodes
Authors: Sassi Mauro , Buccheri Nunzio , Rooney Myles , Botta Chiara , Bruni Francesco , Giovanella Umberto , Brovelli Sergio , Beverina Luca
Published: September 2016

Organic light emitting diodes (OLEDs) operating in the near-infrared spectral region are gaining growing relevance for emerging photonic technologies, such as lab-on-chip platforms for medical diagnostics, flexible self-medicated pads for photodynamic therapy, night vision and plastic-based telecommunications. The achievement of efficient near-infrared electroluminescence from solution-processed OLEDs is, however, an open challenge due to the low photoluminescence efficiency of most narrow-energy-gap organic emitters. Diketopyrrolopyrrole-boron complexes are promising candidates to overcome this limitation as they feature extremely high photoluminescence quantum yield in the near-infrared region and high chemical stability. Here, by incorporating suitably functionalized diketopyrrolopyrrole derivatives emitting at ~760 nm in an active matrix of poly(9,9-dioctylfluorene-alt-benzothiadiazole) and without using complex light out-coupling or encapsulation strategies, we obtain all-solution-processed NIR-OLEDs with external quantum efficiency as high as 0.5%. Importantly, our test-bed devices show no efficiency roll-off even for high current densities and high operational stability, retaining over 50% of the initial radiant emittance for over 50 hours of continuous operation at 10 mA/cm2, which emphasizes the great applicative potential of the proposed strategy.
The role of Rad51 in safeguarding mitochondrial activity during the meiotic cell cycle in mammalian oocytes
Authors: Kim Kyeoung-Hwa , Park Ji-Hoon , Kim Eun-Young , Ko Jung-Jae , Park Kyung-Soon , Lee Kyung-Ah
Published: September 2016

Rad51 is a conserved eukaryotic protein that mediates the homologous recombination repair of DNA double-strand breaks that occur during mitosis and meiosis. In addition, Rad51 promotes mitochondrial DNA synthesis when replication stress is increased. Rad51 also regulates cell cycle progression by preserving the G2/M transition in embryonic stem cells. In this study, we report a novel function of Rad51 in regulating mitochondrial activity during in vitro maturation of mouse oocytes. Suppression of Rad51 by injection of Rad51 dsRNA into germinal vesicle-stage oocytes resulted in arrest of meiosis in metaphase I. Rad51-depleted oocytes showed chromosome misalignment and failures in spindle aggregation, affecting the completion of cytokinesis. We found that Rad51 depletion was accompanied by decreased ATP production and mitochondrial membrane potential and increased DNA degradation. We further demonstrated that the mitochondrial defect activated autophagy in Rad51-depleted oocytes. Taken together, we concluded that Rad51 functions to safeguard mitochondrial integrity during the meiotic maturation of oocytes.
Differential network analysis from cross-platform gene expression data
Authors: Zhang Xiao-Fei , Ou-Yang Le , Zhao Xing-Ming , Yan Hong
Published: September 2016

Understanding how the structure of gene dependency network changes between two patient-specific groups is an important task for genomic research. Although many computational approaches have been proposed to undertake this task, most of them estimate correlation networks from group-specific gene expression data independently without considering the common structure shared between different groups. In addition, with the development of high-throughput technologies, we can collect gene expression profiles of same patients from multiple platforms. Therefore, inferring differential networks by considering cross-platform gene expression profiles will improve the reliability of network inference. We introduce a two dimensional joint graphical lasso (TDJGL) model to simultaneously estimate group-specific gene dependency networks from gene expression profiles collected from different platforms and infer differential networks. TDJGL can borrow strength across different patient groups and data platforms to improve the accuracy of estimated networks. Simulation studies demonstrate that TDJGL provides more accurate estimates of gene networks and differential networks than previous competing approaches. We apply TDJGL to the PI3K/AKT/mTOR pathway in ovarian tumors to build differential networks associated with platinum resistance. The hub genes of our inferred differential networks are significantly enriched with known platinum resistance-related genes and include potential platinum resistance-related genes.
The correlation between cognitive performance and retinal nerve fibre layer thickness is largely explained by genetic factors
Authors: Jones-Odeh Eneh , Yonova-Doing Ekaterina , Bloch Edward , Williams Katie M. , Steves Claire J. , Hammond Christopher J.
Published: September 2016

Retinal nerve fibre layer (RNFL) thickness has been associated with cognitive function but it is unclear whether RNFL thinning is secondary to cortical loss, or if the same disease process affects both. We explored whether there is phenotypic sharing between RNFL thickness and cognitive traits and whether such sharing is due to genetic factors. Detailed eye and cognitive examination were performed on 1602 twins (mean age: 56.4 years; range: 18–89) from the TwinsUK cohort. Associations between RNFL thickness and ophthalmic, cognitive and other predictors were assessed using linear regression or analysis of variance models. Heritability analyses were performed using uni- and bivariate Cholesky decomposition models. RNFL was thinner with increase in myopia and with decrease in disc area (p < 0.001). A thicker RNFL was associated with better performance on mini mental state examination (MMSE, F(5,883) = 5.8, p < 0.001) and with faster reaction time (RT, β = −0.01; p = 0.01); independent of the effects of age, refractive error and disc area (p < 0.05). RNFL thickness was highly heritable (82%) but there was low phenotypic sharing between RNFL thickness and MMSE (5%, 95% CI: 0–10%) or RT (7%, 95% CI: 1–12%). This sharing, however, was mostly due to additive genetic effects (67% and 92% of the shared variance respectively).
The complex evolutionary history of the tympanic middle ear in frogs and toads (Anura)
Authors: Pereyra Martín O. , Womack Molly C. , Barrionuevo J. Sebastián , Blotto Boris L. , Baldo Diego , Targino Mariane , Ospina-Sarria Jhon Jairo , Guayasamin Juan M. , Coloma Luis A. , Hoke Kim L. , Grant Taran , Faivovich Julián
Published: September 2016

Most anurans possess a tympanic middle ear (TME) that transmits sound waves to the inner ear; however, numerous species lack some or all TME components. To understand the evolution of these structures, we undertook a comprehensive assessment of their occurrence across anurans and performed ancestral character state reconstructions. Our analysis indicates that the TME was completely lost at least 38 independent times in Anura. The inferred evolutionary history of the TME is exceptionally complex in true toads (Bufonidae), where it was lost in the most recent common ancestor, preceding a radiation of >150 earless species. Following that initial loss, independent regains of some or all TME structures were inferred within two minor clades and in a radiation of >400 species. The reappearance of the TME in the latter clade was followed by at least 10 losses of the entire TME. The many losses and gains of the TME in anurans is unparalleled among tetrapods. Our results show that anurans and especially bufonid toads, are an excellent model to study the behavioural correlates of earlessness, extratympanic sound pathways and the genetic and developmental mechanisms that underlie the morphogenesis of TME structures.
RNA-seq analysis of the hypothalamic transcriptome reveals the networks regulating physiopathological progress in the diabetic GK rat
Authors: Meng Yuhuan , Guan Yujia , Zhang Wenlu , Wu Yu-e , Jia Huanhuan , Zhang Yu , Zhang Xiuqing , Du Hongli , Wang Xiaoning
Published: September 2016

The Goto-Kakizaki (GK) rat is an animal model of non-obese type 2 diabetes (T2D). The GK rat was generated through the introduction of various genetic mutations from continuous inbreeding; these rats develop diabetes spontaneously. The mutated genes in GK rats may play key roles in the regulation of diabetes. The hypothalamus plays a central role in systematic energy homeostasis. Here, the hypothalamic transcriptomes in GK and Wistar rats at 4, 8 and 12 weeks were investigated by RNA-seq and multiple variants and gene expression profiles were obtained. The number of variants identified from GK rats was significantly greater than that of Wistar rats, indicating that many variants were fixed and heritable in GK rats after selective inbreeding. The differential gene expression analysis indicated that GK rats had a dysfunctional hypothalamic melanocortin system and attenuation of the hypothalamic glucose-sensing pathway. In addition, we generated integrated gene network modules by combining the protein-protein interaction (PPI) network, co-expression network and mutations in GK and Wistar rats. In the modules, GK-specific genes, such as Bad, Map2k2, Adcy3, Adcy2 and Gstm6, may play key roles in hypothalamic regulation in GK rats. Our research provides a comprehensive map of the abnormalities in the GK rat hypothalamus, which reveals the new mechanisms of pathogenesis of T2D.