bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimizing a Translational Mouse Model of Endometriosis
Authors: Howe Christina Ann , Coté John , Stoos Catherine , Bredehoeft Marley , Hallgren Jodi , Waes Janee Gelineau-van
Published: August 2023

Improved animal models of endometriosis are needed to accurately represent the pathophysiology of human disease and identify new therapeutic targets that do not compromise fertility. Current mouse models of endometriosis that involve ovariohysterectomy and hormone replacement preclude evaluation of fertility. Menstrual phase endometrium includes potentially important immune cells and inflammatory mediators. Our goal was to develop a novel, translationally relevant mouse model of endometriosis by transplanting donor menstrual endometrium into the peritoneal cavity of menstruating, immunocompetent, intact recipients. We tested various paradigms to determine the most effective method for establishing endometriotic lesions. Initially, 4 paradigms were tested to optimize method of induction. To enhance the model further, a novel paradigm implanted discrete menstrual phase endometrium via laparoscopy into menstruating mice. Vaginal cytology was performed to confirm continued estrus cyclicity. Potential lesions were harvested during proestrus and confirmed to be endometriosis based on histopathology. All mice demonstrated normal estrus cyclicity post induction. Incidence of endometriosis and the difference in average number of lesions across groups was compared. The use of laparoscopy to place discrete menstrual phase endometrium was the most effective method of induction of endometriosis. This method was just as effective when used to induce endometriosis in menstruating recipient mice, representing a novel translationally relevant model that can be used to assess immunologic factors and the impact of therapeutic interventions on fertility.
A Comparison of the Disease Occurrence of Cerebrovascular Diseases, Diabetes Mellitus, Hypertensive diseases, and Ischaemic Heart Diseases among Hospitalized Older Adults in Thailand
Authors: Suanrueang Passakorn
Published: August 2023

This observational research analyzed public hospital data from the Thailand Ministry of Public Health website to investigate gender differences in four categories of four non-communicable diseases (NCDs) affecting hospitalized senior Thai populations for 12 years. This study aimed to determine the cumulative effects and analyze the odds ratio (OR) according to ICD-10 cause categories for the data from 2010 to 2021, accounting for 1,327,093 cases in 2010 and 2,275,936 cases in 2021. The findings revealed statistically significant gender differences in four categories of NCDs. Men were found to be more likely than women to have two types of NCDs, as measured by the OR and the ratio per 100,000 population ratios (mean and SD): cerebrovascular diseases (OR = 1.34–1.47, 2,413.33 (163.72)), and ischaemic heart disease (OR = 1.24–1.63, 2,853.46 (154.29)). Conversely, diabetes mellitus (OR = 0.64–0.84, 4,539.97 (431.29)) and hypertensive disorders (OR = 0.82–0.95, 8,712.03 (817.39)) were discovered to have a lower likelihood of ratios related in men compared to women. However, the trend of all four NCDs in men has significantly increased every year: cerebrovascular diseases = 0.0093 year(s) + 1.3391, (R2 0.82, p-value .001); diabetes mellitus = 0.0171 year(s) + 0.6143, (R2 0.97, p-value .001); hypertension = 0.0125 year(s) + 0.8091, (R2 0.96, p-value 0.001); and ischaemic heart disease = 0.0345 year(s) + 1.1884, (R2 0.99, p-value .001). Gender, a crucial biological factor, contributes to variations in the prevalence of illness. As such, it is essential to prioritize the disease risk occurrence and preventive care for men and women separately, with a focus on implementing more detailed screening and detection strategies, as well as tailored interventions.
Evaluation of objective and subjective binocular ocular refraction with looking in type
Authors: Fukushima Megumi , Hirota Masakazu , Yukimori Takafumi , Hayashi Akio , Hirohara Yoko , Saika Makoto , Matsuoka Kumiko
Published: August 2023

Background
This study aimed to compare the consistency of objective and subjective ocular refraction using automated binocular refraction system that performs binocular objective ocular refraction and subjective ocular refraction in a single unit with objective ocular refraction using a conventional autorefractometer and conventional subjective ocular refraction in real space.
Methods
Twenty-eight healthy volunteers (21.2 ± 1.5 years old) participated in this study. The objective ocular refractions in the right eye were measured using an automated binocular refraction system and a conventional autorefractometer. The subjective ocular refractions were measured binocular and monocular conditions using the automated binocular refraction system and monocular condition in real space at 5.0 m. The objective and subjective ocular refractions were converted to spherical equivalents (SEs).
Results
The objective SE was significantly and negatively greater with the automated binocular refraction system (objective − 4.08 ± 2.76 D) than with the conventional autorefractometer (objective − 3.85 ± 2.66 D) (P = 0.002). The subjective SE was significantly and negatively greater with the automated binocular refraction system (− 3.55 ± 2.67 D) than with the real space (− 3.33 ± 2.75 D) (P = 0.002). The subjective SE measured under monocular condition with the automated binocular refraction system (− 3.17 ± 2.57 D) was not significantly different from those in the real space (P = 0.33).
Conclusion
The objective and subjective SEs were significantly and negatively greater using the binocular refraction system than in real space. However, the differences were < 0.25 D. These findings suggest that automated binocular refraction system has sufficient performance for clinical use.
Trial registration number:
UMIN000039665
Structured visual and somatosensory stimuli evoke modality-invariant positional and modality specific velocity dynamics during standing
Authors: Rand Troy J. , Mukherjee Mukul
Published: August 2023

Standing postural control is adaptable to environmental constraints. Center of pressure velocity during support surface translations shows the postural control system utilizes feedforward and feedback control mechanisms to adapt to different environmental structures. It is not clear whether the postural response to structured support surface stimuli is modality specific. This study investigated postural responses to support surface translations and visual surround rotations structured to mimic white, pink, or red noise. Positional entrainment was analyzed using cross correlation and cross sample entropy, and velocity responses were analyzed using mean velocity and detrended fluctuation analysis. Entrainment was strongest for red noise and weakest for white noise. Pink noise was similar to white noise for the support surface translations and red noise for the visual surround rotations. Short-term persistence of the postural response was weakened for support surface translations and strengthened for visual surround rotations, it was also affected by the persistence of the stimulus, with stronger response persistence associated with stronger temporal correlation. Long-term anti-persistence became stronger only in the support surface translations and average velocity increased in both modalities. These data indicate differential effects due to the modality of stimulus, but similar effects due to the structure of the stimulus.
The Evidence-Based Research approach for conducting new studies in physiotherapy research. A meta-research study comparing author guidelines of physiotherapy-related journals to those of leading journals with the highest impact factor
Authors: Rosen Diane , Reiter Nils L. , Vogel Barbara , Prill Robert
Published: August 2023

Background: The Evidence-Based Research (EBR) approach requires authors to base their research on a systematic review of the existing literature. Adhering to this approach prevents the generation of redundant scientific studies, thereby avoiding the deprivation of effective therapies for trial participants and the waste of research funds. To promote the adoption of this approach, scientific medical journals could include the EBR approach in their author guidelines. While this applies to all areas of research, it is particularly relevant to physiotherapy and rehabilitation research, which predominantly involve interventional trials in patients.
Objective: The aim of this study was to determine the extent to which the EBR approach is already being requested by physiotherapy-related scientific medical journals (PTJs). In addition, a comparison was made between PTJs and leading journals (LJs), i.e. scientific medical journals with the highest impact factor in the Science Citation Index Extended (SCIE).
Methods: This meta-research study is based on a systematic examination of the author guidelines of 149 PTJs. The journals were identified and included based on the number of publications with physiotherapy as a keyword. The included author guidelines were analysed for the extent to which they specified that new studies should be justified by a systematic review of the literature. Additionally, they were compared with 14 LJs, which were identified by their impact factor in the SCIE.
Results: In their author guidelines, none of the included PTJs required or recommended the use of a systematic review to justify new trials. Among LJs, four journals (28,57%) required the study justification through a systematic review of the literature.
Conclusion: Neither PTJs nor LJs have adopted the EBR approach in their author guidelines. Further efforts are needed to establish the implementation.
Risks and rates, and the mathematical link between them
Authors: Hanley James
Published: August 2023

The risk over a given time span can be calculated as the exponentiated value of the negative of the integral of the incidence density function (or hazard rate function) over that time span. This relationship is widely used but, in the few instances where textbooks have presented it, the derivations of it tend to be purely mathematical. I offer a more intuitive heuristic approach that draws on the conceptualization of a person-year in Edmonds' 1832 definition of the force of mortality, and on the number of replacements in a dynamic population. Similarly I show how the Nelson-Aalen risk estimator can be seen in the context of this historical conceptualization of a person-year, scaled to the experience of a dynamic population of (constant) size 1.
Studies on novel biomarkers of myocardial dysfunction caused by adrenaline through metabolomics
Authors: Xiong Xiaoyu , Li Hongdong , Wang Sa , Xu Feng
Published: August 2023

Epinephrine is important in resuscitation therapy and improves the return of spontaneous circulation after cardiac arrest, but its safety remains an important concern because high doses of epinephrine may worsen myocardial dysfunction, and the underlying pathophysiology remains unclear. In this study, we found that the addition of 1 mg/kg, 2 mg/kg, and 3 mg/kg exogenous adrenaline could induce myocardial dysfunction in rats, and 1 mg/kg adrenaline was the minimum and optimal dose for establishing a myocardial dysfunction model. Through a nontargeted metabolomics approach, we performed a myocardial dysfunction model under 1 mg/kg and identified several associated metabolic pathways, including pyruvate metabolism, regulation of lipolysis in adipocytes and biosynthesis of unsaturated fatty acids. The metabolites of lactate and fatty acids such as cis-9-palmitoleic acid, eicosapentaenoic acid and 2-methyl-3-hydroxybutyric acid were significantly enriched in the epinephrine-treated group compared to the control group (P < 0.05), while carnitines, including L-palmitoylcarnitine, acetylcarnitine and stearoylcarnitine, were significantly depleted in the serum of the epinephrine-treated rats (P < 0.05). A dose-dependent effect of adrenaline on myocardial dysfunction was observed, and further analysis of these metabolites may indicate their suitability as novel diagnostic biomarkers for myocardial dysfunction caused by adrenaline.
Network Pharmacology Analysis and Experimental Validation to Investigate the Mechanism of Flavan-3-Ols and Aromatic Resin in Anxiety
Authors: Ahmad Ansari Vikhar Danish , Ali Syed Ayaz , Yasar Qazi , Khan Subur W
Published: August 2023

Purpose
Pharmacological mechanism of the major bioactive flavan-3-ols and aromatic resin intended for management of anxiety was investigated using network pharmacology, molecular docking, and in vivo studies.
Methods
Using network pharmacology, the targets for antianxiety activity of two flavan-3-ol components and four aromatic resin components was obtained. Protein-protein interaction and KEGG analysis were used to enrich and investigate key pathways. Molecular docking was carried out to evaluate the targets. Elevated plus maze, open field test, light and dark, actophotometer and hole board test were used to study antianxiety effect.
Results
Compound-Target network analysis revealed that many targets were hit by components. The number of nodes are 332 and number of edges are 491. PPI state that our network has significant interaction with (targets) that are involved in anxiety. The KEGG analysis showed major pathways of flavan-3-ols and aromatic resin in managing anxiety are through controlling the calcium signaling route, cholinergic synapses, dopaminergic synapses, and the estrogen signaling system. Molecular docking study of EGCG showed the most active compound showing highest affinity with binding energy − 7.4 kcal/mol towards D2, -7.8 kcal/mol towards GABA, -9.2 kcal/mol for serotonin. An elevated plus maze investigation found the antianxiety impact of flavan-3-ols and aromatic resin. Flavan-3-ols, and aromatic resin combination significantly (p < 0.05) increase the number of entries in the open arm and the total time spent in the open arm. In the light dark test, there was a highly significant (p < 0.01) increase in the time spent in the light region. The time spent in the center area and the number of entries in the center area highly significant (p < 0.01) increases considerably in the open field test. In the hole board test, the number of head dips was substantially (p < 0.01) higher. The number of photo beam interruptions significantly (p < 0.05) increases in the actophotometer.
Conclusion
The network analysis and animal study demonstrated that Flavan-3-ols and aromatic resin had antianxiety characteristics, indicating the necessity for more research to produce a novel antianxiety medication.
Dual-responsive smart nano-platform targeting peptide modifications synergistically enhances multimodal therapy for liver cancer
Authors: Li Lin-Song , Zhao Xue-Jie , Chen Peng-Wei , Cheng Dong , Liu Bang-Bang , Zhao Mei-Xia
Published: August 2023

The success of clinical therapies against liver cancer is largely determined the accuracy rate of treatment. Herein, we designed a dual-responsive smart nano-platform (HMCuS@DOX@9R-P201) could realize multimodal synergistic therapy. The nano-platform could precisely recognize the protein marker FOXM1c-DBD on the surface of HepG2 cells. The apoptosis rate of HepG2 cells reached 98.51% under near-infrared (NIR) laser irradiation, and the tumor inhibition rate of HMCD9P NPs + L treatment group was as high as 88.2% in mice. Moreover, it could up-regulate the apoptosis-related protein Bak, down-regulate PARP-1, Bcl-2, and Caspase 8, and inhibit the pathway protein FOXM1, thus down-regulating Skp2, up-regulate p27Kip1, and precise induction of multimodal synergistic therapy based on chemotherapy, PTT, and PDT to improve anti-HCC efficacy and reduce side effects. Overall, we report a liver cancer-targeted smart nano-platform with promising anti-liver cancer effects and multiple synergistic therapeutic mechanisms.
Plant growth-promoting bacteria inoculation mitigates drought stress effects in Trifolium pratense L. seedlings
Authors: Ebrahimi Mahdieh
Published: August 2023

Multiple ecological factors have an effect on the capacity of plants to survive, grow, and produce. In the meantime, a significant limitation on plant growth in dry regions is drought. Accordingly, the study's objective was to determine the impacts of plant growth-promoting rhizobacteria (PGPR) on indices of germination, growth, and nutrient absorption in the red clover (Trifolium pratense L.) under drought regimes. Treatments included different levels of drought: 100% (FC = field capacity), 70% (0.7FC), and 40% (0.4FC) as the first factor and inoculation conditions of PGPRs, including non-inoculation (control), Azotobacter vinelandii (AV), Pantoea agglomerans and Pseudomonas putida (PA + PP), and combined application of Azotobacter + Pseudomonas (AV + PA + PP), as the second factor. Results revealed that the maximum and minimum germination percentages were obtained for interactions of AV + 0.7FC and control + 0.7FC, respectively. The combined treatment of AV + PA + PP had less impact on reducing drought stress on the germination of seeds than the single application of bacteria. Maximum values for length of roots, shoots, and plant’s dry weight were obtained for AV + 0.4FC interaction, while the minimum values were recorded for PA + PP + 0.4FC interaction. Additionally, results showed that the treatment of PA + PP had no significant influence on drought stress reduction (p > 0.05). The highest uptake of K was observed for the treatment of AV + FC, and the highest amounts of Fe and Zn were measured for the interaction of PA + PP + 0.7FC. The lowest uptake was recorded for Fe, Zn, and Mn under the combined treatment of AV + PA + PP + 0.4FC. In general, the use of Azotobacter compared to Pseudomonas had a better effect on reducing drought impacts on plant characteristics and increased plant tolerance to drought stress.
Variation of Peripheral Blood-based Biomarkers for Response of Anti-PD-1 Immunotherapy in Lung Cancer
Authors: Yan Feng , Wang Xiaoming , Chen Dayu , Ma Yuyan , Mo Dongping
Published: August 2023

The therapeutic regimen of immune checkpoint inhibitors (ICIs) has been a great achievement of elevated survival results in lung cancer, but only a small proportion of patients can benefit from it in the long term. Therefore, peripheral blood-based biomarkers which could effectively predict the efficacy of anti-PD-1/PD-L1 immunotherapy are crucial for selection of dosage regimen. Here we compared the performance of four machine learning models and chose lightGBM model to screen and analyze the most important biomarkers in peripheral blood. The results show that some peripheral immune cell subsets, serum inflammatory and immunological biomarkers are all valuable predictors of therapeutic responses and progression free survival (PFS). In analysis of immune cell subsets, biomarkers positively associated with benefit to immunotherapy are CD4+CD25+, CD3+CD56+and CD4/CD8, while PD-1+ on T cells plays a negative role. The results of inflammatory markers showed that most of them were correlated with disease progression. Moreover, the high expression of serum immunological biomarkers such as ΔCEA%, CYFRA21-1 and NSE may indicate that ICIs is not effective. Our above results provide some promising peripheral blood biomarkers for immunotherapy of lung cancer, and assist the management and therapeutic designing of patients.
Influence of iron on the structure and strength of the Kovar to stainless steel joints by using Cu-Mn-Co-Fe brazing filler metal
Authors: Maksymova Svitlana , Kovalchuk Petro , Voronov Vitaliy
Published: August 2023

The paper presents the results of X-ray spectral microanalysis of dissimilar brazed joints between Kovar and stainless steel, produced by vacuum brazing with the application of Cu-Mn-Co-Fe brazing filler metals. X-ray microspectral analysis established that a two-phase structure is formed in brazed joints, which consist of two solid solutions: the primary phase is the α-Cu solid solution (based on the Cu-Mn system), which takes up the main zone of the seam. The γ-phase (Fe-Mn) crystallizes in the form of isolated discrete grains. It also contains other components of the brazing filler metal. The influence of iron on the structure and mechanical properties of the brazed joints was investigated. It was found that an increase in iron concentration leads to an increase in the quantity of the γ-phase. It was determined that increasing the iron concentration in the initial brazing filler metal from 1% to 2.5% results in the attainment of maximum strength (600 MPa) in the brazed joints, and the samples fail through the stainless steel.
Identification of Prognosis- and Metastasis-related Enhancer RNAs in Renal Cell Carcinoma
Authors: Liu Yifan , Lu Bingnan , Li Man , Yang Tianyue , Qu Mingyu , Yao Yuntao , Song Xu , Pan Xiuwu , Zhou Wang , Cui Xingang
Published: August 2023

Background:

Renal cell carcinoma (RCC) is one of themost prevalent and lethal malignancies globally. Enhancer RNAs (eRNAs) serve as potential diagnostic and prognostic markers andpotential therapeutic targets for cancer. This study aim to explore the roles of enhancer RNAs (eRNAs) in renal cell carcinoma (RCC) metastasis.

Methods:

RNA-seq data of RCC samples were downloaded from the TCGA database and MET500 database. And normalized eRNA expression profiles were obtained from the eRic database. The differential expressed eRNAs (DEEs) were identified through differential expression analysis. Then, identification of prognosis-related DEEs and construction of the prognosis model were conducted by univariate and multivariate Cox regression analysis. Moreover, CIBERSORT, ssGSEA and GSVA algorithm were utilized. Finally, we established a co-expression regulation network including key prognosis-related DEEs, transcription factors, hallmarks of cancer, immune cells/gene sets, target genes of eRNAs, and protein chips using Pearson correlation analysis. Moreover, CMap analysis, multidimensional external validation, ChIP, and ATAC-seq were conducted to highlight our study’s reliability.

Results:

A total of 353 eRNAs were identified as DEEs. 35 prognosis-related DEEs were selected out and a credible prognosis model was established with the Area Under Curve (AUC) of 0.859. In addition, the expression value of 22 kinds of immune cells and 29 immune gene sets were quantified. Ultimately, a co-expression regulation network which consisted of 4 significant prognosis-related DEEs, 11 differential expressed TFs, 23 significant hallmarks of cancer, 13 types of immune cells, 19 immune gene sets, 22 target genes of eRNAs and 20 protein chips was constructed.

Conclusion:

We illustrated that eRNAs played a significant role in RCC metastasis. Four key prognosis-related DEEs (SHROOM3, PWWP2B, ZSCAN5A and DTNA) were identified as therapeutic targets, metastasis and poor prognosis biomarkers.
A Scalable Blockchain Storage Scheme for VANET
Authors: Wei Wenxiang , Zhu Nafei , Wang Jian , Song Hongyu , He Jingsha
Published: August 2023

Intelligent transportation systems (ITSs) make it possible for applications such as autonomous driving, active safety systems and smart cities. As the infrastructure of ITSs, vehicular ad-hoc network (VANET) plays a key role in ensuring traffic safety while improving driving experience and comfort. However, VANET faces many security and privacy challenges as the network is exposed to the public and involves sensitive information such as vehicle control commands and driving records. Although blockchain technology provides such features as decentralization, immutability, non-reliance on trust and traceability, most of the existing blockchain systems have high storage capacity and computing requirements for participating nodes while terminals nodes in VANET, such as road-side units (RSU), on-board units (OBU) and sensors, usually possess limited storage and computing capacity. To solve this problem, this paper proposes a lightweight blockchain system with scalable storage capacity for VANETs. It uses network sharding and multi-consensus strategy to improve the topology and consensus process of the blockchain. Aimed at reducing the storage overhead of RSU nodes that participate in the blockchain, a collaborative storage mechanism and a dynamic copy number strategy for the blockchain ledger is designed. Experimental analysis shows that compared to existing schemes, the proposed blockchain mechanisms can significantly reduce storage requirement for the participating nodes, making it possible for terminal nodes with limited storage in VANET to participate in the blockchain as fully functional nodes, avoiding the trend of blockchain network towards centralization, maximizing the sharing of road traffic information,which would ensure the security, privacy and trustworthiness of information in ITSs.
User Experience Oriented Edge Server Placement
Authors: Wang Shuliang , Liu Shuo , Yang Yijie , Yuan Hanning , Ruan Sijie , Yang Yun
Published: August 2023

Edge computing holds promising prospects and addresses certain limitations of cloud computing. In the realm of edge computing, service providers deploy edge servers in close proximity to users to minimize network latency. To optimize the utilization of limited edge servers, service providers typically adopt a decentralized approach to their placement. However, in real-world edge computing environments, runtime failures are bound to occur after the placement of edge servers, significantly degrading the user experience. Therefore, edge server placement strategies must consider scenarios involving edge server failures.In general, redundant placement techniques are employed to ensure the reliability of services deployed on edge servers. In practice, edge servers consist of one or more physical machines, which leads us to refer to the physical edge server placement as the PESP problem. From the perspective of mobile users, the PESP solution aims to provide cost-effective and stable services. We measure service stability using a robustness metric and, for the first time, introduce the average utility indicator to gauge service efficiency. Average utility pertains to the performance users obtain from edge servers, such as CPU performance. When placing edge servers, we take into account both average utility and robustness to ensure an optimal user experience.In this paper, we formally model the problem of user experience-oriented physical edge server placement (PESPU) and prove its NP-hardness. To tackle this problem, we propose an optimization method based on integer programming (PESPU-O) to find optimal solutions for small-scale problems. For large-scale problems, we present three heuristics to find solutions. Finally, we conduct experiments using real-world datasets to demonstrate the effectiveness and efficiency of our approaches.
Shape transitions of Red Blood Cell under oscillatory flows in microchannels
Authors: Akerkouch Lahcen , Le Trung
Published: August 2023

This paper aims to examine the ability to control Red Blood Cell (RBCs) dynamics and the associated extracellular flow patterns in microfluidic channels via oscillatory flows. Our computational approach employs a hybrid continuum-particle coupling, in which the cell membrane and cytosol fluid are modeled using the Dissipative Particle Dynamics (DPD) method. The blood plasma is modeled as an incompressible fluid via the Immersed Boundary Method (IBM). This coupling is novel because it provides an accurate description of RBC dynamics while the extracellular flow patterns around the RBCs are also captured in detail. Our coupling methodology is validated with available experimental and computational data in the literature and shows excellent agreement. We explore the controlling regimes by varying the shape of the oscillatory flow waveform at the channel inlet. Our simulation results show that a host of RBC morphological dynamics emerges depending on the channel geometry, the incoming flow waveform, and the RBC initial location. Complex dynamics of RBC are induced by the flow waveform. Our results show that the RBC shape is strongly dependent on its initial location. Our results suggest that the controlling of oscillatory flows can be used to induce specific morphological shapes of RBCs and the surrounding fluid patterns in bio-engineering applications.
The Philosophy of Social Reproduction in Modern Sport Globalization: A Barometric Analysis: Based on Barometric Analysis
Authors: Zhou Zhenhua , Hamid Ali Redar
Published: August 2023

There are so many people in so many places who take pleasure in so many different athletic pursuits, which is one marker of advanced human civilization, and also many fields of sports have contributed to the economic success of countries so that introduced culture to each other’s. As bibliometric analysis of technology coverage in HRM journals was performed to use Scopus database. The section on (Sport, Economic, Social Sciences, Business, Management, Accounting, Technology, Human Resource, Econometrics, Finance, and Humanities) just discusses key works connected to HRM technology. The resarch in which made use of the data-visualization software VOS viewer, analyzed the development of the over time, factoring in international cooperation and the frequency of certain keywords. The impact of the sports industry on the global economy and its role in attracting foreign visitors was then analyzed in depth. Finally, that sport is expanding at a rapid rate everywhere in the world, and it is widely recognized as a major economic driver for both individuals and nations.
Gravity Model Applied in External trade between Angola and SADC
Authors: Sandambi Nerhum
Published: August 2023

The paper analyses foreign trade between Angola and SADC in the period 2000- 2013. The main objective is to analyse the factors that influence foreign trade and, above all, to understand the main implications of this. A static gravity model was estimated using fixed effects (FE), random effects (RE) and ordinary least squares (OLS) models. Thus, the following results were obtained; the economic distance in the model is relevant and explains the foreign trade flows, with an impact of 0.978% on the volume of trade traded, the physical distance shows, however, a positive impact, it is plausible and justified by the reduced physical distance between Angola and the SADC member countries, "coeteris paribus". Trade Policy, through the Tariff variable, the results suggest an impact of 0.366% on the trade volume traded with member countries, keeping everything else constant, the FRONT dummy variable is relevant and explains the trade volume, being the trade made with the countries with which Angola shares the border, the impact is significantly higher, intuitively, the lower the costs related to the factors of attraction in the economy tend to be. Thus, the real effective exchange rate variable shows a negative impact, which translates into a decrease in trade volume, the impact may be related to volatility in the foreign exchange market.

JEL classification: c01; c21; c23; c33; F10
Post-COVID Conditions at the Delivery Hospitalization
Authors: Carlson Jeffrey M , Simeone Regina M , Wallace Bailey , Ellington Sascha , Saydah Sharon , Tong Van T
Published: August 2023

This study describes the frequency of post-COVID conditions and other co-occurring health outcomes at the delivery hospitalization. PCC diagnoses occurred in 0.02% of delivery hospitalizations and were more frequent in pregnant people who were White, had private health insurance, and delivered preterm.
Assessment of Drinking Water Quality of the People Living Around the Barishal District, Bangladesh.
Authors: MAMUN MD. AL , RAFID MD. IMTIAZ FARUK , SAZZAD GOLAM , MIAH RAKIB
Published: August 2023

Bangladesh is a densely populated country in South-East Asia. Increasing population along with increasing development activities lead to exploitation and pollution of water supplies readily available to us. Therefore, water quality indicators are imposed as a global problem to determine its suitability for individual uses as well as to establish major strategies for optimal use of water resources. Failure to ensure safe drinking water with efficient purification systems will leave communities vulnerable to waterborne outbreaks with harmful health conditions.
Evaluation of Hydrologic Data for Irrigation System Design:
A Case Study
Authors: Uche Uche E
Published: August 2023

The scope and the efficient operation of an irrigation system depends on systematic collection, collation, and analysis of the hydrological/meteorological data of the project area. Relying on existing rainfall records, the peak rainfall, mean rainfall, rainfall frequency and effective monthly rainfall were established. Atayi stream discharge characteristic curve was used to determine the stream stage-discharge relationship while the instantaneous rate of discharge of the stream was determined using float. The generated data was plotted on a hydrograph to obtain 2.64m3/s. The high-level volume discharge and the low-level flow per annum were found to be 29.08m3 and 18.33m3 respectively. For the crop evapotranspiration, the Penman open water evaporation was deployed using climatic data for Igwu scheme as collected by Umudike Research Institute, Umuahia to obtain 1871 mm per annum compared to 2200mm by Piche or Pan evaporation. The site hydrologic data collected and analyzed support the adequacy of basic hydrologic factors for irrigated paddy rice cultivation in the study area.
Die private Lastenradnutzung – Statussymbol oder Alternative zum eigenen Auto? Eine qualitative Untersuchung der instrumentellen, affektiven und symbolischen Motive
Authors: Trost Laura
Published: August 2023

Bei der Realisierung der dringend nötigen Verkehrs- und Mobilitätswende sind Möglichkeiten der Befriedung menschlicher Mobilitätsbedürfnisse unabhängig von privater Autonutzung ein wichtiger Baustein. Im Rahmen dieser Arbeit werden darum instrumentelle, affektive und symbolische Motive der privaten Lastenradnutzung qualitativ erforscht. Das Lastenrad hat in den vergangenen Jahren insbesondere in urbanen Räumen an Popularität gewonnen und ermöglicht für den Transport von weiteren Personen, insbesondere Kindern, Tieren oder größeren Lasten eine emissionsarme oder -freie Fortbewegung. Die Untersuchungsergebnisse zeigen, dass bei den instrumentellen Motive die häufig nach Gender verteilte Sorgearbeit eine entscheidende Rolle einnimmt. Dabei erfüllt das Lastenrad das von den Ansprüchen Transportoptionen, Zeitsouveränität, Geschwindigkeit, Erreichbarkeit und Multifunktionalität geprägte Mobilitätsbedürfnis von Personen, die neben Sorge- auch Lohnarbeit im Alltag leisten, im urbanen Raum auf einzigartige Weise. Auch für Personen, deren Alltag nicht maßgeblich durch diese Doppelbelastung geprägt ist, stellt die mit dem Lastenrad mögliche optimierte Überwindung von Raum- und Zeitwiderständen ein relevantes instrumentelles Motiv dar. Hinzu kommen soziale Interaktion, Gesundheit und Klimaschutz. Dabei ist die Lastenradnutzung stark mit positiven emotionalen Reaktionen und hedonischem Erlebniswert verknüpft. Symbolisch drückt sie einen hohen finanziellen und sozialen Status der Besitzer*innen aus und genießt hohes Ansehen in ihrem sozialen Umfeld. Gleichzeitig kann mit der Lastenradnutzung das Bedürfnis nach Individualität und Distinktion erfüllt und der hohe Stellenwert, den nachhaltige Mobilität für die Lastenradbesitzer*innen dieser Untersuchung hat, ausgedrückt werden.
Indikatorengestützte Ansätze zur nachhaltigen urbanen Mobilität: Ergebnisse einer Literaturanalyse
Authors: Bücher Julius
Published: August 2023

Das Forschungsprojekt „MOWENDIKO: Konzeptstudie zur Entwicklung eines Mobilitätswendeindex für Kommunen“ untersucht die Einflussfaktoren auf urbane, nachhaltige Mobilität vor dem Hintergrund, dass bisher keine umfassende, standardisierte und wissenschaftlich fundierte Bestimmung von Indikatoren, welche den Fortschritt einer Mobilitätswende in Kommunen abbildet, besteht. Hierfür wird der zentrale Begriff der Mobilitätswende in den wissenschaftlichen Diskurs über die sozio-ökologische Transformation von Mobilität und Verkehr eingeordnet und das Konzept der Mobilitätskulturen erläutert, das als Ausgangspunkt für die Erfassung der vielfältigen Einflussfaktoren auf Verkehr und Mobilität dient. Grundlage der Erarbeitung des Mobilitätswendeindex ist die Untersuchung von indikatorengestützten Ansätzen aus dem Bereich nachhaltige, urbane Mobilität, die im Rahmen einer Literaturanalyse untersucht wurden. Analysiert wurden 35 Indikatorensysteme, die Aspekte von Mobilität, Radverkehr, Fußverkehr, Öffentlicher Verkehr und Nachhaltigkeit abbilden. Die Ergebnisse der Literaturanalyse verdeutlichen, dass ein solcher Index sowohl subjektive als auch objektive Einflussfaktoren auf Mobilität abbilden sollte. Darüber hinaus zeigt sich, dass der Fokus auf die Operationalisierung des politischen Prozesses der Mobilitätswende eine Lücke in der bisherigen Forschung zur indikatorengestützten Analyse von Mobilität und Verkehr darstellt.
Pengembangan Buku Ajar Pengantar Dasar Matematika Berbasis Kitab Taqrib Dalam Meningkatkan Kemampuan Literasi Mahasiswa
Authors: Kholil Mohammad , Mukhlis Mohammad
Published: August 2023

The purpose of this study is to develop a textbook for introductory mathematics based on the taqrib book to improve student literacy skills and find out the feasibility, practicality, and effectiveness of textbook for introductory mathematics based on the taqrib that has been developed. The type of research used is Research and Development (R&D) which is designed using the Borg and Gall development model.  The subjects of the development product trial in this study were students of the class 2022 semester 1 of the MTK1, MTK2, and MTK3 classes of mathematics education study program at FTIK UIN KHAS Jember. This research produces a textbook of introduction to basic mathematics based on the taqrib book as students' reference book in lectures on basic introduction to mathematics in semester 1. The resulting textbook is validated by three validators with validation results without any revisions, so the textbooks developed are feasible for use. Furthermore, the resulting textbooks were tested on 1st-semester students of the mathematics education study program at FTIK UIN KHAS Jember. The results of this product trial were 84.49% with a practical category. The mathematical literacy ability of students in semester 1 of the Mathematics Education study program has increased from a total average score of 77.32 to 86.27. Based on these results, it can be said that the use of textbooks for introductory mathematics based on taqrib books is very effective in improving students' mathematical literacy skills.
Pengembangan E-LKPD untuk Meningkatkan Kemampuan Pemecahan Masalah Matematis Peserta Didik pada Materi Bangun Ruang Sisi Lengkung
Authors: Sarman Afriano Andri , Suastika I Ketut , Murniasih Tatik Retno
Published: August 2023

This research aims to develop a valid, practical, and effective electronic student worksheet based on Liveworksheets that can enhance students’ mathematical problem-solving abilities. The indicator for these abilities include problem identification, procedure design, problem-solving, and conclusion drawing. The research and development of these electronic student worksheets have the benefit of providing interactive teaching materials for mathematics learning. The ADDIE development model was used in this research and development process. The research instruments include expert validations sheets, teacher and student response questionnaires were employed to measure practicality. The effectiveness of the electronic student worksheet was evaluated based on activity scores, response scores, and student test scores. The validity percentage of this electronic student worksheet was 78.67% for materials and 90% for media. The practicality of the electronic student electronic student worksheet  was determined through the percentage of positive responses, with 96% from teacher and 84.33% from students. The average student activity score was 55.12, the response score was 45.06, and the student test score was 68.08. The electronic student worksheet developed in this study successfully enhanced students’ mathematical problem-solving abilities according to the predefined indicators.
Multi-wavelength Raman spectroscopy of natural nanostructured carbons
Authors: Isaenko Sergey , Shumilova Tatyana , Bocharov Vladimir , Ulyashev Vasily
Published: August 2023

There is an extensive range of carbon substances with poorly ordered structures that are not well understood. Yet they are important indicators of conditions of related geological processes. The carbon minerals include nanocrystalline graphite, natural analogs of glass-like carbon (GLC)—shungite and impact ultrahigh-pressure GLC, recently discovered ultranocrystalline diamond, as well as natural carbon nanocomposites of diamond, lonsdaleite, and graphite. Studying these natural carbon substances using a standard Raman approach with excitation by visible radiation may lead to a significant distortion of the understanding of their phase states. This paper presents in detail for the first time the spectral features of natural, poorly ordered, and multiphase sp2-sp3 carbon composites by multi-wave Raman spectroscopy using laser excitations from visible to ultraviolet light applied to natural low-ordered carbon substances—nanocrystalline graphite and shungite, nanocrystalline and ultranocrystalline diamond, and multiphase carbon aggregates. The carbon state resolution advantages of ultraviolet Raman spectroscopy for phase analysis of nanostructured and poorly ordered polycomponent carbon substances containing sp2- and sp3-carbons are presented. Raman spectroscopy with ultraviolet excitation can also be applied in the analysis of industrial carbon materials, such as glassy carbon and functional carbon nanocomposites, including ultranocrystalline diamond, lonsdaleite, and amorphous sp3-carbon components.
Relaciones euro-latinoamericanas: perspectivas sobre la consolidación de la cooperación comercial birregional
Authors: Insignares Cera Silvana , Rueda Fiorentino Mariangela
Published: August 2023

El presente artículo analiza las relaciones euro-latinoamericanas con especial atención en el ámbito comercial a nivel CAN y Mercosur. Puntualmente, se orienta a responder a las siguientes preguntas: ¿cómo se materializa la cooperación comercial de la UE en los procesos de integración latinoamericanos CAN y  Mercosur? ¿qué lecciones derivan de las dinámicas de asociación comercial entre estos bloques? Luego de revisar el papel de la UE como actor global y la importancia de su relacionamiento estratégico con AL, este trabajo sostiene que la relación comercial birregional se manifiesta en tres niveles de interacción: primer acercamiento, acción recíproca y consolidación. La naturaleza misma de las negociaciones, así como las disposiciones y decisiones internas de ambos procesos (CAN y  Mercosur) habría favorecido en el caso de la CAN avanzar hacia la consolidación de las relaciones con la UE mientras que en el caso de  Mercosur aún hay obstáculos por superar.
Palabras clave: Unión Europea; América Latina; Cooperación; CAN, Mercosur.
Análisis de la retórica en los títulos de los proyectos para el sostenimiento de la paz financiados por el Fondo de Naciones Unidas
Authors: Garay Vargas Javier Leonardo , Marin Aranguren Erli Margarita , León López Maira Alejandra
Published: August 2023

Este artículo presenta un primer resultado del proyecto “evaluación de impacto de proyectos financiados por la cooperación internacional en organizaciones de la sociedad civil”, en el que se busca recolectar evidencia sobre la efectividad de la cooperación internacional. Aquí los hallazgos del análisis de texto de los proyectos que obtuvieron financiación del Fondo Multidonante para la Paz administrado por la Organización de Naciones Unidas, como evidencia sustancial de prácticas y hechos en este tipo de herramientas. Se interrelaciona el análisis cuantitativo con el cualitativo para un acercamiento desde el análisis de texto y la teoría de cambio en los títulos de los proyectos financiados y de esta manera se perfila no solo la estructura del fondo, sino las tendencias en materia de cooperación internacional, sus prioridades y preferencias, que se codifican en el estudio. De esta manera, la propia experiencia de investigación se convierte en el core del abordaje de estas temáticas que, en este caso, tienen una práctica única en el mundo. El artículo se divide en las siguientes partes: Primera, se da cuenta de un breve estado del arte y marco teórico utilizado para la realización de esta investigación. Segundo, se aborda la metodología de trabajo de la investigación. Tercero, se mencionan algunas características generales de los proyectos financiados por el Fondo. Luego, se muestran los hallazgos relacionados con los títulos. Al final, se proveen algunas conclusiones que sirven de guía para la continuación de la investigación 
Palabras claves: cooperación internacional; sociedad civil; Naciones Unidas; análisis de discurso; paz
La Diplomacia Pública de la Unión Europea en Colombia: ¿Contribuye a una mejora en su percepción?
Authors: Tremolada Eric , Quiroga Chacón Gloria Andrea
Published: August 2023

La Diplomacia Pública, como forma de relacionamiento en el ámbito internacional, es un fenómeno que ha ganado terreno en años recientes. Como instrumento de influencia en la percepción de los individuos, las relaciones internacionales no solo se centran en los actores clásicos, sino también en la sociedad civil y en sus organizaciones, de ahí la pertinencia de preguntarse si la Diplomacia Pública de la Unión Europea en Colombia, contribuye a una mejora en su percepción.
Con este propósito, fundamentados en el reciente Estudio de Percepción de la UE que incluyó a Colombia y el relacionamiento de más de seis décadas que ha tenido la Unión con los bloques latinoamericanos y el país, se evidenció que se trata de una política perfectible con mucho por hacer.
Palabras clave: Diplomacia Pública; Unión Europea; pilares del relacionamiento con Colombia; percepción.
El futuro de las organizaciones internacionales
Authors: García Núñez Luis Fernando
Published: August 2023

La Cátedra Jean Monnet de Derecho Internacional de la Universidad Externado de Colombia ha realizado una extraordinaria y fecunda labor. Son 16 años de convocatorias con las cuales, en solo la Colección IUS COGENS, ha publicado nueve números. El titular de la Cátedra, el profesor Eric Tremolada Álvarez, ha sido el impulsor de esta actividad anual. Este número, el nueve de la citada Colección, está dividido en tres partes. La primera, trata de los “Debates inacabados del derecho y la política internacional”. La segunda de “Las organizaciones internacionales ante la pandemia”. La tercera, y última sección, se titula “Intereses nacionales versus multilateralismo”. Este tomo de la Cátedra revela la experiencia docente e investigativa que quiere proponer otras miradas y la búsqueda de alternativas para resolver las complejas realidades del mundo. Entre otros, se destaca el artículo de Carlo Tassara, un académico de especiales virtudes y con un amplio recorrido universitario y de investigador como lo atestigua su magnífica obra. En el artículo, en compañía de Mariángela Rueda, se reconoce el papel cumplido por la Unión Europea: “… a partir de los años noventa la Unión Europea (UE) se ha ido consolidando como un modelo de integración regional y como un actor global en el escenario internacional”. La obra del profesor Tassara es un recorrido esencial en los estudios de la Unión Europea y de la cooperación internacional.
Palabras clave: Cátedra Jean Monnet, organizaciones internacionales, pandemia, multilateralismo, Carlo Tassara, Unión Europea, cooperación internacional.