bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving the quality of services rendered at tourist facilities for business tourists in Greater Moscow
Authors: Dzhandzhugazova E.A. , Golondarev K.S.
Published: October 2020

Subject. This article analyzes the quality of services provided and methods for improving it at tourist enterprises of Greater Moscow, focused on business tourists travel.
Objectives. The article aims to develop recommendations to improve the quality of the services provided in Greater Moscow for business travelers to polish up the the city's image as a center for business events.
Methods. For the study, we used the methods of multivariate analysis, forecasting, and extrapolation.
Results. The article proposes a developed set of basic measures to improve the quality of services for business travelers.
Conclusions. The results obtained are a necessary basis for the development of the image of Moscow as a center for business events and the development of a business tourism cluster in Greater Moscow.
GREEN SUPPLY CHAIN MANAGEMENT : MEDIASI DAYA SAING DAN KINERJA PERUSAHAAN MANUFAKTUR
Authors: Jumady Edy , Fajriah Yana
Published: October 2020

Pentingnya issu ramah lingkungan terkait aktivitas industri manufaktur di Kota Makassar saat ini menjadi perhatian khusus. Green supply chain management mengintegrasikan antara manajemen rantai pasokan dengan dengan manajemen lingkungan, sehingga penting dilakukan agar dapat mengurangi dampak lingkungan. Penelitian ini bertujuan untuk mengukur pengaruh green supply chain management terhadap daya saing, pengaruh green supply chain management terhadap kinerja perusahaan, pengaruh daya saing terhadap kinerja perusahaan, serta pengaruh green supply chain management terhadap kinerja perusahaan dengan daya saing sebagai variabel intervening. Penelitian ini menggunakan metode deskriptif dan untuk menguji hipotesis digunakan statistika inferensial yaitu Generalized Structured Component Analysis (GeSCA). Sampel penelitian ini berjumlah 75 responden manajer perusahaan manufaktur. Hasil penelitian menunjukkan: green supply chain management berpengaruh positif dan signifikan terhadap daya saing perusahaan, green supply chain management berpengaruh positif dan signifikan terhadap kinerja perusahaan, daya saing berpengaruh positif dan signifikan terhadap kinerja perusahaan, dan green supply chain management berpengaruh positif dan signifikan terhadap kinerja perusahaan dengan daya saing sebagai variabel intervening.
Quantitative Constituents Analysis of Rice Mill Wastewater
Authors: Islam Motaharul , Nasrin Taslema , Rahman Mosiur , Islam Mofizul , Kanti Ray Tushar
Published: October 2020

In the present world, climate change is a mass talked issue. Because of climate change, humans and animals are under the risk of threatening. The scientist has pointed out that main reasons for climate change are waste. Waste is generated from household chores and industries, factories etc. that are affecting the balance of the environment in many ways. This waste may be of various types such as solid, liquid, gaseous etc. Therefore, the study was taken to assess the chemical components contain in wastewater in Dinajpur Sadar, Bangladesh. This study was aimed to evaluate the chemical compositions of the generated wastewater including comparison with the groundwater. The data concerning to the rice mill waste water in Dinajpur, Bangladesh was obtained from individual field visits by interviewing with owner and worker in the rice mills. The wastewater samples were collected randomly from different rice mills. A laboratory experiment was performed to determine the chemical constituents of the wastewater sample. The wastewater contained of pH(6.11-6.18), EC(181.47-185.23 ÂµScm-1), Na(26.19-28.89 mgl-1), Ca(45.41-51.26 mgl-1), Mg(47.12-49.8 mgl-10), K(184.7-191.3 mgl-1), TDS(45.94-47.96 mgl-1), HT(306.7-332.33 mgl-1), S(11.05-13.25 mgl-1), Cl-(522.45-526.182 mgl-1), HCO3-(5.12-6.99 mgl-1), DO(0.46-0.53 mgl-1), P(17.01-21.54 mgl-1). The obtained concentration of Ca, EC, pH, Na and HCO3- were within the reported range of groundwater in Dinajpur, Bangladesh. The concentration of Cl-, K, P, Mg and hardness in the wastewater were above the concentration of reported groundwater in Dinajpur, Bangladesh. On the other hand, the concentration of TDS in the wastewater was less than the reported concentration of groundwater in Dinajpur, Bangladesh.
Vigilancia tecnológica del sector agroindustrial
Authors: Andrade Juan Manuel , Ramírez Plazas Elías , Quintero Alexander
Published: October 2020

La gestión científica y tecnológica en la actualidad resulta imperativo para el desarrollo regional y nacional, especialmente en sectores con importancia social y económica. Por tal motivo, el presente artículo presenta un estudio de Vigilancia Tecnológica para el sector agroindustrial, a partir de ecuaciones de búsqueda en la base de datos Scopus. Asimismo, se definió el plan para el estudio que contempla cuatro etapas: producción científica, autores destacados en la producción científica, países con mayor número de publicaciones e instituciones destacadas con producción científica. Finalmente, se evidenció la tendencia creciente durante la década estudiada en investigaciones relacionadas con la utilidad de subproductos y propiedades de los productos de origen agropecuario.
Construcción del conjunto ternario de cantor a través de la dinámica simbólica
Authors: Polania Quiza Luis Arturo , Penagos Rojas Anderson Felipe
Published: October 2020

Se presenta y utiliza en el siguiente artículo, un grupo de propiedades que contribuyen a la construcción del Conjunto Ternario de Cantor acudiendo a la dinámica simbólica, cuya función es caracterizar las estructuras de las órbitas de un sistema dinámico dado por medio de una sucesión de símbolos. Siendo el Conjunto Ternario de Cantor, en términos topológicos, un conjunto compacto, infinito y perfecto, no denso en cualquier intervalo.
Prediagnóstico y acciones de mejora del proyecto “Parque Jardín Botánico de Neiva”
Authors: Delgado Rivas Edinson Oswaldo , Martínez Moncaleano Carlos Javier , Amézquita Lizcano Jhonatan , Leiva Morantes Luis Enrique , Pastrana Trompa Gloria Ángela
Published: October 2020

Este trabajo identifica las principales potencialidades y problemáticas del proyecto “Parque Jardín Botánico de Neiva", en donde se propone un plan de manejo preliminar determinando los factores desfavorables y sus posibles soluciones. En primer lugar, se realiza una aproximación teórica de los ecosistemas estratégicos abordando sus características y la normatividad que los rige, seguidamente, se identifican los principales problemas que afectan el parque, planteando algunas hipótesis. Asimismo, se proponen posibles acciones de mejoramiento. Finalmente, el estudio concluye que, formulando políticas ambientales, participativas innovadoras y sustentables, minimizarían el impacto ambiental en el parque.
Saussure au futur. Reseña
Authors: Băltăreţu Thénault Créola
Published: October 2020

La aparición repentina e inesperada en 1996 del manuscrito intitulado De la esencia doble del lenguaje (incluido en los Escritos de lingüística general de 20021) suscitó un brote de interés hacia Ferdinand de Saussure además de una verdadera renovación del saussurismo. El descubrimiento de este manuscrito de apariencia sistemática, singular tratado de lingüística general redactado por Saussure a comienzos de los años 1890, nos recuerda no solo la existencia de un importante corpus de textos saussureanos originales accesibles desde los años cincuenta (notas de estudiantes y autógrafos), pero sobretodo el hecho de que su lectura permita además reinterpretar ese corpus (como da cuenta de ello por ejemplo el número de Arena Romanistica de 2013, reeditado en el 2016 en las prensas de la editorial Lambert Lucas, dirigido por François Rastier y titulado significativamente “De la esencia doble del lenguaje y la renovación del saussurismo”, en particular el artículo de Simon Bouquet que figura en ese número y que tiene como subtítulo “Cuando De la esencia doble del lenguaje reinterpreta los textos saussureanos”).
La unidad de análisis como herramienta metodológica de la práctica Psico-Educativa en la escuela
Authors: Medina Fonseca Camilo
Published: October 2020

El presente artículo es producto de algunas discusiones dadas en la cátedra de psicología educacional de la Universidad de Buenos Aíres Argentina durante el primer cuatrimestre académico de 2016. La finalidad de este escrito es presentar la propuesta del Circulo Bio-Geo-Gráfico el cual se fundamenta principalmente en el concepto de Unidad de análisis de Vygotsky y que posteriormente Erausquin y D’Arcangelo desarrollan como herramienta de lectura de las situaciones problemáticas emergentes en las instituciones educativas. En este sentido el círculo se muestra como propuesta de 1) unidad de análisis, de 2) cartografía o herramienta de lectura que guíe la unidad de análisis y 3) como parte de los legajos escolares.
El método de la función de green en el cálculo del campo eléctrico bidimensional para una corriente eléctrica en una guía de onda rectangular
Authors: Herrera Álvarez Sergio , Lizcano Muñoz Jheison , Segovia-Chaves Francis
Published: October 2020

Las ecuaciones diferenciales aparecen frecuentemente en varias áreas de la matemática y de la física. El trabajo de George Green en 1825 sobre el método de la función de Green se ha convertido en una herramienta de la física matemática para abordar problemas que involucran ecuaciones diferenciales no-homogéneas bajo ciertas condiciones de contorno. Este método abarca problemas desde la física clásica hasta abordar complejos problemas contemporáneos de la materia condensada y teoría cuántica de campos. En este trabajo se describe de manera general el método de la función de Green para encontrar la solución de la ecuación de onda no-homogénea del campo eléctrico en una guía de onda rectangular, mediante una expansión en autofunciones.
EVALUASI SISTEM PENGENDALIAN INTERN FUNGSI PENJUALAN PADA UD. MITRA NIAGA SURABAYA
Authors: Paramitha Melvie , Agustina Silvia
Published: October 2020

Pengendalian internal sangat mempengaruhi risiko penjualan. Dengan adanya pengendalian internal yang baik pada penjualan maka dapat mengurangi risiko yang dapat terjadi. Penelitian ini bertujuan untuk mengetahui dan mengevaluasi sistem pengendalian fungsi penjualan yang telah diterapkan pada UD Mitra Niaga. Evaluasi dilakukan untuk menganalisa pengendalian internal yang ada di perusahaan serta memberikan saran rekomendasi yang baik bagi perusahaan.Objek penelitian dalam peneletian ini adalah UD. Mitra Niaga Surabaya yang merupakan perusahaan dagang. Metode analisis data yang dilakukan dengan metode deskriptif yaitu mengumpulkan, mengolah dan menginterprestasikan data yang diperoleh sehingga dapat memberikan gambaran yang jelas mengenai keadaan yang diteliti. Dalam penelitian ini menggunakan metode wawancara, observasi, dan dokumentasi.Hasil dari penelitian ini menunjukkan bahwa UD. Mitra Niaga Surabaya masih banyak mengalami masalah-masalah seperti perusahaan tidak memiliki SOP yang baik, pemilik yang jarang datang ke perusahaan serta stok opname hanya dilakukan 1 tahun sekali. Hal ini menunjukkan bahwa perusahaan belum menerapkan sistem pengendalian yang baik sesuai dengan teori COSO
PRESUPPOSITION TRIGGERS - A COMPARATIVE ANALYSIS BETWEEN ORAL NEWS AND WRITTEN ONLINE NEWS DISCOURSE
Authors: Thoyyibah Luthfiyatun
Published: October 2020

Information becomes a crucial thing that someone gets in everyday terms. Dealing with the digital era, people can get the information through any communication devices. Then, language still has its own rule in communication. As part of linguistic features, the notion of presupposition and its triggers have been studied by many scholars, linguists and philosophers, but as far as the researcher knows, the comparison between presupposition triggers on news broadcast and online transcript has not been explored yet. Therefore, the present research tries to identify the main presupposition triggers used in both transcripts. This is a descriptive qualitative study where it is designed to describe the case of the study by words or sentences rather than numbers. The object of the study is presupposition found in both CNN different news style. Accordingly, two transcripts were analyzed in terms of presupposition triggers, namely existential, factive, lexical, non-factive, structural, counter-factual, adverbial, and relative. The analyses of the transcripts revealed that the most frequently used presupposition trigger in both varieties of oral discourse was existential. It refers to the ability of existential presupposition in diverting attention to other parts of the sentence or utterance. Keywords: presupposition, triggers, presupposition triggers, discourse
AN ANALYSIS OF FILLERS USED BY LECTURER AND STUDENTS IN EFL CLASSROOM INTERACTION
Authors: Fatimah Gotin Siti
Published: October 2020

This paper reports on how fillers are used by lecturer and students in EFL Classroom Interaction. Therefore, the study was aimed to investigate the types and frequency of the lecturer and the students’ fillers and the functions of fillers in EFL Classroom Interaction. A qualitative case study was obtained through the observation. Then, the data from the observations were analyzed by transcribing the whole of the utterances that contained fillers to find out the types, frequency and functions of fillers. The data from observation was described qualitatively. In the present study, the writer proposed two research questions: (1) Which types of lexicalized and unlexicalized fillers will be used and how often do the lecturer and the students use both fillers in EFL Classroom Interaction? (2) What are the functions of lexicalized and unlexicalized fillers used by the lecturer and the students in EFL Classroom Interaction? In responding to the first research questions, It was found that the lecturer  and the students used filler in their utterances, the fillers  found were both lexicalized and unlexicalized fillers. The lecturer used 504 fillers, while the students used 65 fillers. Furthermore, the result of second research question also found. The highest percentage of the fillers’ function of the lecturer and the students reached the same range used as a mark hesitation : (28.91%) for the lecturer and (77.5%) for the students.Keyword: Discourse Markers, Fillers, Classroom Interaction
PERCEPTIONS OF THE NON-ENGLISH DEPARTMENT LECTURERS TOWARDS CLIL IN HIGHER EDUCATION
Authors: Suryani Fitri Budi
Published: October 2020

Content and Language Integrated Learning (CLIL) is an approach to learning activity that uses foreign language as a medium for learning content so that the competence on the language and the subject area content can be achieved simultaneously. CLIL can be implemented in elementary level, secondary level, as well as tertiary or higher education level. In higher education, CLIL might have two significant reasons to be implemented: the globalized world and university internationalization. So far in Indonesia, nearly all universities have not implemented CLIL yet. This study aims at finding out the lecturers’ perceptions towards CLIL in higher education. The participants of the study were thirty-three lecturers from non-English departments of Universitas Muria Kudus. The intrument to collect the data was closed-ended questionnaire. The result reveals that the non-English department lecturers quite disagree for CLIL to be implemented in higher education. Their objection for having English as a medium of instruction seems to lie in their own ability of English as well as their students’ poor English proficiency. Keywords: CLIL, higher education, non-English department lecturers
MALE AND FEMALE STUDENTS’ PERCEPTIONS TOWARD THE IMPLEMENTATION OF VIDEO CONFERENCE AS A DISTANCE LEARNING MEDIA THAT ENHANCES TEACHERS’ PRODUCTIVITIES
Authors: Permatasari Yelis Bintang
Published: October 2020

This paper reports the implementation of video conference as a distance learning media that enhances teachers’ productivities in teaching English in a state high school in Tasikmalaya, West Java.  To give much greater size sample, this study took two sample classes with the overall fifty-six students participated in this study by using cluster sampling technique. This study employed a qualitative research design focusing on the survey study method. A self-administration of twenty questionnaires provided to identify the distinctions perceptions between male and female students thought. A depth information appear to be as important to gain more in-depth information and continuous responses to explore the advantages and its disadvantages of video conferencing that have been undertaken by interviewing the students. The findings revealed that despite some limitation, the teaching and learning process with video conferencing was successful, then male students appear more favorably and react positively compared to female students. By having more positive responses, video conferencing proven to enhance teachers’ productivities. More significantly, students argue on its advantages and disadvantages of video conferencing that was undertaken by interview. The advantages of video conference such as video conference could connect between teachers and students wherever they are, video conference alow them to access lessons with teachers separately, video conference motivated, video conference enhances teachers’ role, responsibility, creativity, and students’ insights and learning experiences using new learning systems. Besides, video conference also has weaknesses or disadvantages when it is applied such as interactions limits, unstable internet connections, unclear sounds, video delay, and background noises. This can be noted that today learning and teaching process can benefit from using video conference as a distance learning media that teachers can used to improve their productivity, as well as substitution for teachers’ absences in the classroom, so that learning can be done, and teacher productivity maintained wherever they are. Keywords: Male and Female, Video Conference, Distance Learning Media,                     Teachers’ Productivities.
Aplicação do nursing activities score nas unidades de terapia intensiva brasileira: revisão integrativa da literatura
Authors: Monteiro Sara Alves , Souza Wyctória Carvalho Alves de , Silva Lucas Alves , Oliveira Nelisnelson da Silva , Bispo de Barros Francisco Railson
Published: October 2020

Objetivo: Identificar a aplicabilidade do instrumento que mede a carga de trabalho de enfermeiros nas Unidades de Terapia Intensivas brasileiras. Métodos: trata-se de um estudo de revisão integrativa, realizado por meio de consulta as bases de dados Banco de Dados em Enfermagem (BDENF), Scientific Electronic Library Online (SCIELO), Latino-Americano e do Caribe de Informação em Ciências da Saúde (LILACS) e Medical Literatura Analysis and Retrieval (MEDLINE), no período de 2009 a 2019. Resultados: Os cruzamentos de busca nas bases de dados estabelecidas, resultaram na identificação de 44 artigos no BDENF, 71 no LILACS, 80 no PUBMED e 16 no SciELO, totalizando 241 estudos. A aplicação dos três filtros possibilitou refinamento que resultou em seleção final de 17 artigos com base na relevância e na qualidade dos dados. Observou-se que o instrumento é utilizado para quantificar e dimensionar os profissionais de enfermagem, assim como classificar a gravidade do paciente, tendo em vista os setores hospitalares considerados críticos. para a presente revisão. Considerações finais: evidenciou-se que a enfermagem intensiva brasileira tem se utilizado do Nursing Activities Score para auxilia-los na qualificação e quantificação da assistência prestada, dimensionamento da equipe de enfermagem e acompanhamento da evolução clínica do paciente em situação crítica.
Métodos não farmacológicos para alívio da dor durante o trabalho de parto: revisão sistemática
Authors: Pereira Ana Cláudia Costa , Costa Ana Luiza Melo Lima , Costa Alice Brant , Geber Bettina , Alkmim Bruna Ferreira , Camarano Giulia Costa Val , Glória Rafaela Resende da , Nogueira Taruany Melo , Ripari Vitória Alagia , Lopes Adriel Gustavo
Published: October 2020

Objetivo: Avaliar por meio de uma revisão a importância dos métodos não farmacológicos para a construção de uma melhor vivência do trabalho de parto. Métodos: Revisão sistemática realizada nas bases de dados MEDLINE/PubMed, LILACS e SciELO, com o uso dos descritores “Terapias Complementares” e “Dor do Parto”, juntamente com o operador lógico de pesquisa "AND". Incluiu-se artigos em inglês, espanhol e português com o recorte temporal de 2016 a 2020. Resultados: Foram selecionados 19 artigos de ensaios clínicos randomizados. Avaliou-se as seguintes técnicas complementares: acupressão, auriculoterapia, aromaterapia, bola suíça, exercício respiratório, yoga, terapia floral, massagem, métodos térmicos e banho de aspersão como métodos não farmacológicos para o controle da dor durante o trabalho de parto. Considerações Finais: As terapias complementares são importantes aliadas no controle da dor, na promoção de uma sensação de satisfação e no fornecimento de um suporte para as parturientes. O uso destes meios não farmacológicos pode viabilizar uma melhor vivência do trabalho de parto, proporcionando um parto mais humanizado ao colocar a mulher como protagonista.
Vírus da Imunodeficiência Humana no contexto ambulatorial: desvelando o perfil e formas de transmissão
Authors: Angelim Rebeca Coelho de Moura , Brandão Brígida Maria Gonçalves de Melo , Freire Daniela de Aquino , Oliveira Denize Cristina de , Marques Sérgio Corrêa , Abrão Fátima Maria da Silva
Published: October 2020

Objetivo: Descrever, segundo a ótica de profissionais de saúde, as principais formas de transmissão do Vírus da Imunodeficiência Humana/Síndrome da Imunodeficiência Adquirida identificadas na prática diária e as mudanças do perfil das pessoas que vivem com o vírus. Métodos: Trata-se de estudo qualitativo, realizado com 46 profissionais de saúde. Para coleta de dados foi utilizada a técnica de entrevista semiestruturada. As falas foram gravadas, transcritas e analisadas por meio da técnica de análise de conteúdo lexical. O estudo foi aprovado por Comitê de Ética em Pesquisa. Resultados: Duas categorias foram apreendidas: formas de transmissão do vírus e mudanças no perfil de pessoas vivendo com o vírus, evidenciando uma substituição do conceito de grupos de risco pelo de vulnerabilidade. Conclusão: A principal forma de transmissão do vírus é por via sexual.  A transmissão vertical e transfusão sanguínea também foram elencadas. Houve também uma mudança no perfil da doença, considerando que hoje qualquer pessoa que apresente comportamento de risco está vulnerável ao vírus.
Relato de caso: existe associação entre lesão neoplasia intraepitelial cervical III com doença tireoidiana autoimune?
Authors: Ribeiro Leonora Alves , Da Silva Gabriel Bianchi , Rosa Junior Siderleu Pires , Green Márcia Cristina Taveira Pucci
Published: October 2020

Objetivo: Relatar um caso de uma paciente, relacionando a infecção de HPV (papilomavírus humano) de alto risco oncogênico somado a uma lesão NIC III, com a doença tireoidiana autoimune. Detalhamento do caso: Trata-se de um relato de caso, do tipo descritivo transversal, feito a partir da análise do prontuário e do acompanhamento de uma paciente em seguimento no Ambulatório Escola, pertencente esse ao Complexo da Santa Casa de Misericórdia de Franca, e aprovado pelo Comitê de Ética da mesma fundação. Aborda-se o caso de uma paciente de 34 anos, com diagnóstico de hipotireoidismo há 2 anos, que apresentou ao rastreamento de câncer de colo uterino uma lesão intraepitelial de alto grau NIC ll/lIl, sendo realizado conização para tratamento. Houve uma investigação sobre essas duas afecções e suas alterações na imunidade humoral e inata, além do estresse causado pela doença. Considerações finais: Conclui-se que analisando o curso da lesão NIC III e da doença tireoideana, visto que as duas doenças possuem uma importante associação com a imunidade, observamos uma possível relação entre tais patologias.
Comprehensive Non-Targeted Analysis of the Prenatal Exposome Reveals Significant Differences in Chemical Enrichment Between Maternal and Fetal Samples
Authors: Abrahamsson Dimitri , Wang Aolin , Jiang Ting , Wang Miaomiao , Siddharth Aditya , Morello-Frosch Rachel , Park June-Soo , Sirota Marina , Woodruff Tracey J.
Published: October 2020

The exposome has been recognized as an important dimension in understanding human disease and complementing the genome but remains largely uncharacterized. We analyzed 295 matched maternal and cord blood samples using non-targeted high-resolution mass spectrometry and characterized exposome features. We compared the chemical enrichment of the maternal and cord blood samples using a similarity network analysis and examined the interactions between the exogenous and the endogenous chemical features using a molecular interaction networks approach. We detected over 700 chemical features in the maternal and cord pairs and we found that maternal samples are more similar in terms of chemical enrichment to their corresponding cord samples compared to other maternal samples or other cord samples. We observed significant associations between 3 poly/perfluoroalkyl substances (PFAS) and endogenous fatty acids in both the maternal and cord samples indicating important interactions between PFAS and fatty acid regulating proteins. To our knowledge, this is the first non-targeted analysis study that uses such large cohort to characterize the prenatal exposome.
A Cloud Computing Platform for Scalable Relative and Absolute Binding Free Energy Prediction: New Opportunities and Challenges for Drug Discovery
Authors: Lin Zhixiong , Zou Junjie , Peng Chunwang , Liu Shuai , Li Zhipeng , Wan Xiao , Fang Dong , Yin Jian , Gobbo Gianpaolo , Chen Yongpan , Ma Jian , Wen Shuhao , Zhang Peiyu , Yang Mingjun
Published: October 2020

Free energy perturbation (FEP) has become widely used in drug discovery programs for binding affinity prediction between candidate compounds and their biological targets. Simultaneously limitations of FEP applications also exist, including but not limited to, the high cost, long waiting time, limited scalability and application scenarios. To overcome these problems, we have developed a scalable cloud computing platform (XFEP) for both relative and absolute free energy predictions with refined simulation protocols. XFEP enables large-scale FEP calculations in a more efficient, scalable and affordable way, e.g. the evaluation of 5,000 compounds can be performed in one week using 50-100 GPUs with a computing cost approximately corresponding to the cost for one new compound synthesis. Together with artificial intelligence (AI) techniques for goal-directed molecule generation and evaluation, new opportunities can be explored for FEP applications in the drug discovery stages of hit identification, hit-to-lead, and lead optimization with R-group substitutions, scaffold hopping, and completely different molecule evaluation. We anticipate scalable FEP applications will become widely used in more drug discovery projects to speed up the drug discovery process from hit identification to pre-clinical candidate compound nomination.
In Silico Design of Peptides with Binding to the Receptor Binding Domain (RBD) of the SARS-CoV-2 and Their Utility in Bio-Sensor Development for SARS-CoV-2 Detection
Authors: Badhe Yogesh , Gupta Rakesh , Rai Beena
Published: October 2020

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions of people across the globe and created not only a health emergency but also a financial crisis. This virus attacks on the angiotensin-converting enzyme 2 (ACE2) receptor situated on the surface of the host cell membrane. The spike protein of the virus binds to this receptor which is a critical step of infection. A molecule which can specifically stop this binding could be a potential therapeutic. In this study, we have tested 12 potential peptides which can bind to the receptor binding domain (RBD) of the spike protein of the virus and thus can potentially inhibit the binding of the latter on ACE2 receptor. These peptides are screened based on their binding with RBD of the spike protein and aqueous stability, obtained using several atomistic molecular dynamic simulations. The potential of mean force calculation of two most promising peptides confirmed their binding to the RBD of the spike protein. Furthermore, these two potential peptides were tested for their use in a biosensing application for SARS-CoV-2 detection. Two types of biosensing platforms, a graphene sheet and a carbon nano tube (CNT), were tested. The peptides were modified in order to functionalize the graphene and CNT. Based on the interaction between the substrate, peptide and spike protein, the utility of screened peptide for a given bio sensing platform is discussed and recommended.
Use of Altmetrics to Analyze ScholarWorks in Natural Resource Management
Authors: Kulhavy David L. , Reynolds R. P. , Unger D. R. , McBroom M. W. , Hung I-Kuai , Zhang Yanli
Published: October 2020

Digital preservation of library materials has increased the need for methods to access the documents and contents maintained in digital archives. The use of altmetrics to quantify the impact of scholarly works, including PlumX, is increasing readership by listing articles in reference services. The outreach from the digital repository ScholarWorks at Stephen F. Austin State University (SFASU) highlights the impact within the natural resources community from Digital Commons, Forest Sciences Commons; and from the Natural Products Chemistry and Pharmacognosy Commons. The use of PlumX altmetrics was examined to evaluate usage, impact, and digital audience downloads for the Arthur Temple College of Forestry and Agriculture (ATCOFA) at SFASU.
Associations between serum levels of thyroid stimulating hormone (TSH), free thyroxine (fT4), free triiodothyronine (fT3) and clinical symptoms in patients diagnosed with Hashimoto’s thyroiditis
Authors: Wiśniewski Karol , Bełej Monika , Wojtkiewicz Joanna
Published: October 2020

Introduction:
Hashimoto’s thyroiditis (HT), with prevalence of about 0.8%, is one of the most common autoimmune disorders in the world. Due to the fact that HT affects level of thyroid hormones, symptoms of HT are from almost every body system.

Aim:
The aim of this study was to estimate the correlations between symptoms reported by patients with HT and the level of TSH, fT3 and fT4 and also to check the frequency of reporting each symptom at presentation and to estimate the frequency of other co-existing with HT autoimmune diseases.

Material and methods:
This study included 65 patients with HT who decided to complete the online survey.

Results and discussion:
The most common among the reported symptoms were fatigue (77%), sleepiness (60%) and weak concentration (57%). The results also showed higher prevalence of: rheumatoid arthritis, coeliac disease, systemic lupus erythematous, diabetes mellitus type 1, inflammatory bowel disease and atopic dermatitis than in general population. Significant correlations were found between TSH level and the symptoms including: weak concentration (P = 0.0002), easy freezing (P = 0.02) and body weight gain (P = 0.02). There was also a correlation between level of fT3 and physical exercise (P = 0.02).

Conclusions:
The findings in this study suggest that there is a higher relative risk for some autoimmune disorders (especially rheumatoid arthritis, coeliac disease and systemic lupus erythematous) for people with HT. The findings also suggest that some symptoms of HT correlate with the level of thyroid parameters.
Galileo Uydu Sistemi ve Sinyal Yapısı
Authors: PIRTI Atınç , HOŞBAŞ Ramazan Gürsel , ŞENEL Burak , KÖROĞLU Mehmet , BİLİM Serdar
Published: October 2020

Küresel konum belirleme sistemleri günümüzde devrim olarak nitelendirilebilir. Bu sistemler herhangi bir cismin yaklaşık olarak konumunun belirlenmesinde, ulaşım araçlarının navigasyonunda, birçok ölçme işleminde ve buna benzer hayatı kolaylaştıracak birçok alanda kullanılabilmektedir. Çok hassas zaman bilgileri aracılığıyla üç boyutlu uzay geriden kestirme yöntemi sonucunda yüksek doğruluk ve hızlı işlem süreleriyle en çok tercih edilen sistemler olmuşlardır. Dünya çapında Global Konum Belirleme Sistemi (Global Positioning System-GPS), GLONASS (Globalnaya Navigatsionnaya Sputnikova Sistema) sistemleri aktif olarak kullanılmaktadır. Bu iki sistemin yanında GALILEO uydu sistemi de emin adımlarla ilerlemektedir. GALILEO sistemi sivil olarak birçok alana hizmet vermeyi planlamaktadır. Bu çalışmada GALILEO’nun özelliklerine, sinyallerine, ortaya çıkış aşamalarına, diğer sistemlerle arasındaki farklılıklara ve neden ihtiyaç duyulduğuna değinilmektedir.
Prevalence of malignancy in thyroid nodule at People’s Medical College Hospital (PMCH) Nawabshah.
Authors: Zardari Inayat Ali , Memon Zulfiqar Ali Imtiaz , Khowaja Mashooque Ali , Karim Bhatti Naeem Ul , Ghumro Altaf Hussain , Soomro Imtiaz Ali
Published: October 2020

Objectives: The purpose of study is to ascertain the prevalence of malignancy in thyroid single/multiple nodules after ascertaining the features of nodules on different criteria. Study Design: Cross Sectional Study. Setting: Department of Surgical at PMCH Nawabshah. Period: April 2015 to April 2018. Material & Methods: All patients got admission from OPD and they were investigated for the disease. All biochemical examinations were done. Thyroid profile with thyroid scan was obtained. Fine Needle Aspiration Cytology (FNAC) was done to diagnose the type of cells either benign/ malignant. The decision of the surgical procedure was done according to the FNAC report of the thyroid nodule. Results: Total 80 patients were investigated. 55 (68.75%) females, 35 (43.75%) male and 60 (75%) showed the benign cells and 20 (25%) patient’s reports had malignant cells. Biopsies were sent for histopathology. 60 (75%) showed thyroid adenomas after biopsy. 10(12.5%) patients papillary carcinoma, 7 (8.75%) follicular, 2 (2.5%) medullary, 1 (1.25%) anaplastic, 0 for thyroid lymphoma, 0 thyroid carcinoma. 0 for squamous cell carcinoma. 40 (50%) were treated conservatively with thyroxine, 20 (25%) were operated for lobectomy. All malignant cases were undergone for total thyroidectomy. Conclusion: it is summed up that the prevalence of malignancy in thyroid nodules in our setup is only 25% that is the lower one as compared to other studies.
Effect of zinc supplement on glycemic control and lipid abnormalities in Type 2 diabetic patients.
Authors: Farooq Muhammad , Ali Arshad , Islam Nayyer Ul , Niaz Furquana , Islam Yousuf Ul , Tabassum Urooj
Published: October 2020

To evaluate the effects of zinc on glycemic control and lipid profile in type 2 diabetic patients. Objectives: The zinc deficiency is reported in with diabetes, which increases oxidative stresses leading to complications of diabetes. Previous studies demonstrated that zinc supplementation improved glucose control in patients with diabetes, but limited data is available and single blind trials. Study Design: Randomized Controlled study. Setting: Combined Military Hospital (CMH) Malir Cantt, Karachi. Period: 1st December 2018 to 30th June, 2019. Material & Methods: Patients (n=350) were randomly divided into two groups. The first group (n=175) was supplemented with oral zinc sulfate 30 mg/day and second group (n=175) received placebo for a period of 3 months. Blood samples were taken at baseline and after 3 months to assess fasting blood glucose (FBS), glycosylated hemoglobin (HbA1C %) and serum lipid levels and BMI which were compared by t test for paired samples. Results: The mean age of all subjects was 51.80+10.281 years and male to female ratio was 1.08:1. The mean BMI was 31.74+5.806. There was no statistical difference in age and gender between two groups but more obese patient received placebo. The zinc supplemented group had a significant reduction in FBS (p= 0.032) compared to placebo (p= 0.158). The HbA1C% level reduced significantly in zinc supplemented group (p<0.001).compared to the placebo group (p=0.273). Serum lipid levels reduced significantly in the zinc supplemented group (p<0.001) but no significant changes observed in the placebo group (p=0.395). Conclusions: Zinc supplementation improved glycemic control and decreased levels of serum cholesterol, LDL and triglyceride.
The bacterial spectrum of spontaneous bacterial peritonitis in patients with cirrhosis of liver.
Authors: Babar Ahmad Nawaz , Rasool Shahid , Azhar Salman , Komal Javeria , Hanif Sofia
Published: October 2020

Objectives: To identify the bacterial spectrum of SBP in patients with cirrhosis of liver. Study Design: Descriptive Cross-sectional study. Setting: Department of Gastroenterology and Hepatology, Madina Teaching Hospital, Faisalabad. Period: 1st November, 2018 – 30th June, 2019. Material & Methods: Two hundred and fifty cirrhotic patients having ascites and clinical symptoms and signs of SBP, consecutively admitted in the ward or presented to OPD were included in the study. Results: A total of 250 patients included in this study. SBP was diagnosed according to the predetermined criteria in 140 patients.  The culture-negative ascites was found in 77 (55%) and culture-positive ascites was found in 63 (45%) patients. The most common organism was E.Coli 28 (47.45%) followed by Enterococcus 10 (16.94%), Klebsiella Pneumoniae 6 (10.17%), Streptococcal Pneumoniae 5 (8.47%), S.aureus 5 (8.47%), Acinetobacter 3 (5.08%) and miscellaneous 2 (3.38%). Conclusion: The percentage of SBP is quite high among patients having cirrhosis and ascites and the Gram-negative bacterial spectrum is still much common in our region.
Hepatitis E associated fulminant hepatic failure and its outcome in pregnancy.
Authors: Brohi Zahida Parveen , Parveen Uzma , Sadaf Aneela
Published: October 2020

Objectives: To determine the clinical features and outcome of hepatitis E associated fulminant hepatic failure in pregnancy. Study Design: Observational Retrospective study. Setting: Department of Obstetrics & Gynecology at Isra University Hospital Hyderabad. Period: Three years from 1st January 2015 to 31st December 2017. Material & Methods: Total 3596 obstetric patients were admitted whom 168 pregnant women who were positive for hepatitis E viral marker have been included in the study. Results: Their age was between 18 to 47 years with mean age 26.04±6.40 years; majority of patients had not received antenatal care 123 (73.2%). Out of 168, 27 (16%) presented in the first trimester, 45 (26.7%) presented in the second trimester, while 96 (57.1%) patients developed fulminant hepatic failure in their 3rd trimester of pregnancy. Out of 168, 111(66%) patients delivered and 57 (33.9%) were undelivered. Fetal and perinatal outcome of delivered patients showed miscarriage 45 (40.5%), stillborn 25(14.8%), preterm delivery 17(15.3%), neonatal death 7 (6.3%) and 17 (15.3%) new born remained alive. Overall maternal mortality was 51 (30.3%). Conclusion: Hepatitis – E related fulminant hepatic failure in pregnancy is a troublesome clinical issue and connected with exceptionally high maternal and fetal mortality. Appropriate diagnosis, early timely intervention can considerably diminish the morbidity and mortality associated with (HEV) Fulminant hepatic failure.
Association of hypertension and diabetic retinopathy in type 2 DM patients.
Authors: Saqib Ali , Sarfraz Muhammad , Anwar Touseef , Alam Muhammad Absar , Khan Rizwan Rasul , Zafar Zafar Ali
Published: October 2020

Objectives: To evaluate the association of hypertension and diabetic retinopathy in type 2 DM patients. Study Design: Case Control study. Setting: Diabetic Clinic Department of Medicine, Independent University Hospital, Faisalabad. Period: From January 2019 to June 2019. Material & Methods: One Hundred Type 2 diabetic patients of either sex were reviewed and these patients were screened for diabetic retinopathy using welchallyn ophthalmoscope. The patients with diabetic retinopathy fulfilling the inclusion criteria were placed in group A (cases) and patients without diabetic retinopathy were placed in group B (control). After resting the patient in supine position for 5 minutes, blood pressure (BP) measurements were taken in all these patients using mercury sphygmomanometer in two successive out-patient department visits, and mean value of B.P. was taken. All patients were asked for duration of diabetes, hypertension and visual problems specifically. These patients were advised following investigations: - FBS. - RBS. - HbAlc. Relevant statistics, mean & standard deviation were computed for variables. T-test was applied on hypertension (independent) and DM retinopathy (dependent) variables. Results: Systolic and diastolic blood pressure were significantly higher in the patients with retinopathy (mean systolic B.P 153.4± 17.13 and mean diastolic B.P. 84.1±9.26) than in those without retinopathy (mean systolic B.P. 130.65±11.94 and mean diastolic B.P 77.3 ±6.64). There was significant correlation of diabetic retinopathy with systolic hypertension (P<0.05) and diastolic hypertension (P<0.001). Conclusion: There is strong association between diabetic retinopathy and hypertension. So early detection and treatment of hypertension can retard the development and progression of diabetic retinopathy.
Frequency of obstructive pattern on spirometry in asymptomatic chronic smokers.
Authors: Umer Zaid , Hayat Irum , Waseem Muhammad , Aziz Nauman , Afzal Hafiza Swaiba , Kamal Zahid
Published: October 2020

Objectives: To know the frequency of obstructive pattern on spirometry in asymptomatic chronic smokers. Study Design: Cross-sectional study. Settings: Department of Pulmonology, Sahiwal Medical College Sahiwal. Period: 1st Nov, 2019 to 1st May 2020. Materials & Methods: A total of 205 chronic smokers aged 30-60 years were included. Patients with history of Ischemic heart disease, previously diagnosed cases of COPD and asthma were excluded. Spirometry was done by using portable spirometer by consultant pulmonologist (at least 2 years of post-fellowship experience) and obstructive pattern (COPD) was noted. Results: Majority males with ages between 41 to 50 years( mean age 47.78 ± 4.90 years)  out of the 205 patients, 137 (66.83%) were male and 68 (33.17%) were females with male to female ratio of 2:1. Mean duration of smoking was 8.81 ± 4.67 years. Mean height was 161.81 ± 9.23 cm. Mean weight was 78.81 ± 5.67 kg. Mean BMI was 26.21 ± 5.39 kg/m2. In this study, frequency of obstructive COPD on spirometry in asymptomatic chronic smokers was found in 29 (14.15%) patients. Conclusion: This study established that frequency of obstructive pattern on spirometry in asymptomatic chronic smokers is high.
Pharmacological treatment of COVID-19: an update
Authors: Onwudiwe Oyiyechukwu A , Weli Homayemem , Shaanu Toluwanimi A , Akata Nkechi M , Ebong Imoh L
Published: October 2020

Background

The ongoing coronavirus disease-19 (COVID-19) pandemic, caused by the novel coronavirus 2 (SARS-CoV-2) has triggered a worldwide search for medications addressing the morbidity and mortality associated with it. Various medications have been proposed and applied to control COVID-19 based on previous experiences with other viral infections. Some of these have been shown to be harmful or lack efficacy. This review discusses the medications that have been repurposed for SARS-CoV-2, experimental medications undergoing clinical trials, as well as the regional variations in COVID-19 treatments.

Methods

A literature search was conducted to cover the period of January 2020 to September 2020 using the keywords “medications, treatment, therapeutics, pharmacological management for COVID-19” in various combinations as search strings. PubMed, LitCOVID, Google Scholar, Science Direct, and clinicaltrials.gov were the databases utilized.

Results

Evidence from ongoing clinical trials has shown promise with antiviral medications such as remdesivir, as well as corticosteroids, and convalescent plasma for severe cases of COVID-19. There is still, however, some conflicting evidence on the true benefits of these treatments. Other medications such as interferons, monoclonal antibodies, immune modulators, do not have enough clinical evidence of their safety and efficacy in COVID-19 patients for their recommended use. The role of anticoagulants and pulmonary vasodilators is still being explored. The efficacy of hydroxychloroquine is yet to be demonstrated in COVID-19 patients and is currently no longer recommended. Experimental medications targeting specific viral proteases are future promising therapies.

Conclusions

The retinue of medications being used to treat COVID-19 is evolving and expanding as more clinical trials provide results. Several potential medication therapies are currently being investigated. While awaiting an approved safe and efficacious medication to treat this virus, a periodic review of on-going research is highly encouraged.
O educador e a escola de tempo integral no Brasil: quem vai “fazer acontecer”?
Authors: Mendonça Mercês Pietsch Cunha , Lobato Iolene Mesquita , Santos Edna Perpetua dos
Published: October 2020

O artigo discorre sobre o papel do educador na educação integral e integrada no Brasil. Pretende-se analisar como o modelo integral foi construído, implementado e como está sendo revisto, bem como as necessidades de interação dos diversos atores no processo de EII. Também discute os requisitos de uma educação integral e integrada e o nível de preparação docente para implementação desse modelo. Sugerem-se questionamentos sobre a importância do professor enquanto implementador, analisador, catalisador de melhorias e aprendizado, enfim, protagonista do processo de EII e busca-se ao final ressaltar que melhorias, ainda, podem ser feitas para que o “filtro” pelo qual todo aluno passa esteja cada vez mais eficaz em sua função.
Discussão sobre formação de professores, inicial e continuada e a relação com a nova BNCC
Authors: Leal Simone Das Graças , Borges Maria Célia , Ribeiro Betânia De Oliveira Laterza
Published: October 2020

O artigo traz uma discussão sobre a formação de professores e inclui aspectos históricos, teóricos ou conceituais e políticos relativos ao tema. Objetiva contribuir na discussão em alguns aspectos relativos às políticas e práticas de formação docente, os quais se encontram diluídos em aspectos da formação inicial, da formação continuada e da formação continuada em serviço atrelada à base curricular. O delineamento metodológico teve como base a pesquisa bibliográfica e documental. Destacamos a importância ínfima dada ao tema pelas políticas públicas, demarcadas nos parcos investimentos financeiros, nas descontinuidades dos projetos e na consolidação das práticas de formação ao longo da história.  Nesse sentido, recentemente, a Resolução nº 2 de 2015, que representava um avanço para a Diretrizes Curriculares, foi substituída pela Resolução nº 2 de 2019, indicando um perfil mais tecnicista para o profissional docente. Ressaltamos a urgência da luta coletiva por mudanças na valorização da empreitada da formação de professores, o que vai, certamente, incidir na melhoria da qualidade de ensino nas escolas públicas.
The use of “structural prefabrication” in the Flaminio Stadium by Pier Luigi and Antonio Nervi.
A technical-constructive study aimed at formulating guidelines for a future conservation plan
Authors: Vittorini Rosalia , Capomolla Rinaldo
Published: October 2020

The paper highlights the specificity and originality of the solutions adopted by Nervi in the construction of the Flaminio Stadium (Pier Luigi and Antonio Nervi, 1957-59), as well as his talent as a designer and engineer. The text presents both a summary of the research carried out on the terracing and the canopy of the Stadium (built using “structural prefabrication”) and draws attention to the research methodology, of which this study is a part. The research was funded by the Getty Foundation with the aim of formulating guidelines for the future conservation project of the Stadium.