bluuebunny/crossref_metadata_2025 huggingface dataset:
RUNX1 Regulates a Transcription Program That Affects the Dynamics of Cell Cycle Entry of Naive Resting B Cells
Authors: Thomsen Inesa , Kunowska Natalia , de Souza Roshni , Moody Anne-Marie , Crawford Greg , Wang Yi-Fang , Khadayate Sanjay , Whilding Chad , Strid Jessica , Karimi Mohammad M , Barr Alexis R , Dillon Niall , Sabbattini Pierangela
Published: November 2021

RUNX1 is a transcription factor that plays key roles in hematopoietic development and in hematopoiesis and lymphopoiesis. In this article, we report that RUNX1 regulates a gene expression program in naive mouse B cells that affects the dynamics of cell cycle entry in response to stimulation of the BCR. Conditional knockout of Runx1 in mouse resting B cells resulted in accelerated entry into S-phase after BCR engagement. Our results indicate that Runx1 regulates the cyclin D2 (Ccnd2) gene, the immediate early genes Fosl2, Atf3, and Egr2, and the Notch pathway gene Rbpj in mouse B cells, reducing the rate at which transcription of these genes increases after BCR stimulation. RUNX1 interacts with the chromatin remodeler SNF-2–related CREB-binding protein activator protein (SRCAP), recruiting it to promoter and enhancer regions of the Ccnd2 gene. BCR-mediated activation triggers switching between binding of RUNX1 and its paralog RUNX3 and between SRCAP and the switch/SNF remodeling complex member BRG1. Binding of BRG1 is increased at the Ccnd2 and Rbpj promoters in the Runx1 knockout cells after BCR stimulation. We also find that RUNX1 exerts positive or negative effects on a number of genes that affect the activation response of mouse resting B cells. These include Cd22 and Bank1, which act as negative regulators of the BCR, and the IFN receptor subunit gene Ifnar1. The hyperresponsiveness of the Runx1 knockout B cells to BCR stimulation and its role in regulating genes that are associated with immune regulation suggest that RUNX1 could be involved in regulating B cell tolerance.
B Cell Activation and Plasma Cell Differentiation Are Promoted by IFN-λ in Systemic Lupus Erythematosus
Authors: Barnas Jennifer L , Albrecht Jennifer , Meednu Nida , Alzamareh Diana F , Baker Cameron , McDavid Andrew , Looney R John , Anolik Jennifer H
Published: November 2021

Type I IFN is essential for viral clearance but also contributes to the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE), via aberrant nucleic acid–sensing pathways, leading to autoantibody production. Type III IFN (IFN-λ) is now appreciated to have a nonredundant role in viral infection, but few studies have addressed the effects of IFN-λ on immune cells given the more restricted expression of its receptor primarily to the epithelium. In this study, we demonstrate that B cells display a prominent IFN gene expression profile in patients with lupus. Serum levels of IFN-λ are elevated in SLE and positively correlate with B cell subsets associated with autoimmune plasma cell development, including CD11c+T-bet+CD21− B cells. Although B cell subsets express all IFN receptors, IFNLR1 strongly correlates with the CD11c+CD21− B cell expansion, suggesting that IFN-λ may be an unappreciated driver of the SLE IFN signature and B cell abnormalities. We show that IFN-λ potentiates gene transcription in human B cells typically attributed to type I IFN as well as expansion of T-bet–expressing B cells after BCR and TLR7/8 stimulation. Further, IFN-λ promotes TLR7/8-mediated plasmablast differentiation and increased IgM production. CD11c+ B cells demonstrate IFN-λ hyperresponsive signaling compared with other B cell subsets, suggesting that IFN-λ accelerates plasma cell differentiation through this putative extrafollicular pathway. In summary, our data support type III IFN-λ as a cytokine promoting the Ab-secreting cell pool in human viral and autoimmune disease.
Hematopoietic Stem Cell Requirement for Macrophage Regeneration Is Tissue Specific
Authors: Eddins Devon J , Kosters Astrid , Waters Jeffrey , Sosa Jasmine , Phillips Megan , Yadava Koshika , Herzenberg Leonore A , Kuipers Hedwich F , Ghosn Eliver Eid Bou
Published: November 2021

Tissue-resident macrophages (TRMΦ) are important immune sentinels responsible for maintaining tissue and immune homeostasis within their specific niche. Recently, the origins of TRMΦ have undergone intense scrutiny, in which now most TRMΦ are thought to originate early during embryonic development independent of hematopoietic stem cells (HSCs). We previously characterized two distinct subsets of mouse peritoneal cavity macrophages (MΦ) (large and small peritoneal MΦ) whose origins and relationship to both fetal and adult long-term (LT) HSCs have not been fully investigated. In this study, we employ highly purified LT-HSC transplantation and in vivo lineage tracing to show a dual ontogeny for large and small peritoneal MΦ, in which the initial wave of peritoneal MΦ is seeded from yolk sac–derived precursors, which later require LT-HSCs for regeneration. In contrast, transplanted fetal and adult LT-HSCs are not able to regenerate brain-resident microglia. Thus, we demonstrate that LT-HSCs retain the potential to develop into TRMΦ, but their requirement is tissue specific in the peritoneum and brain.
Absence of ERAP1 in B Cells Increases Susceptibility to Central Nervous System Autoimmunity, Alters B Cell Biology, and Mechanistically Explains Genetic Associations between ERAP1 and Multiple Sclerosis
Authors: O’Connell Patrick , Blake Maja K , Godbehere Sarah , Aldhamen Yasser A , Amalfitano Andrea
Published: November 2021

Hundreds of genes have been linked to multiple sclerosis (MS); yet, the underlying mechanisms behind these associations have only been investigated in a fraction of cases. Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an endoplasmic reticulum–localized aminopeptidase with important roles in trimming peptides destined for MHC class I and regulation of innate immune responses. As such, genetic polymorphisms in ERAP1 have been linked to multiple autoimmune diseases. In this study, we present, to our knowledge, the first mechanistic studies performed to uncover why polymorphisms in ERAP1 are associated with increased susceptibility to MS. Combining multiple mouse models of CNS autoimmunity with high-dimensional single-cell spectral cytometry, adoptive transfer studies, and integrative analysis of human single-cell RNA-sequencing datasets, we identify an intrinsic defect in B cells as being primarily responsible. Not only are mice lacking ERAP1 more susceptible to CNS autoimmunity, but adoptive transfer of B cells lacking ERAP1 into B cell–deficient mice recapitulates this susceptibility. We found B cells lacking ERAP1 display decreased proliferation in vivo and express higher levels of activation/costimulatory markers. Integrative analysis of single-cell RNA sequencing of B cells from 36 individuals revealed subset-conserved differences in gene expression and pathway activation in individuals harboring the MS-linked K528R ERAP1 single-nucleotide polymorphism. Finally, our studies also led us to create, to our knowledge, the first murine protein-level map of the CNS IL-10+ immune compartment at steady state and during neuroinflammation. These studies identify a role for ERAP1 in the modulation of B cells and highlight this as one reason why polymorphisms in this gene are linked to MS.
A Case Report of Rare Adverse Events Associated with Venlafaxine Administration: Hypoglycemia and Lactic Acidosis
Authors: Özdemir Serdar
Published: November 2021

We report the first case of hypoglycemia and lactic acidosis caused by the therapeutic doses of venlafaxine. A 19-year-old female patient had presyncope and she was taking venlafaxine 75 mg once a day because of major depression for a week and she had no history of any other drug use or disease. The blood gas analysis revealed hypoglycemia and lactic acidosis. Patient was treated with dextrose infusion and oral diet. Although hypoglycemia and lactic acidosis have been reported in overdose of venlafaxine in the literature, these effects were observed in therapeutic doses.
The efficacy of okra fruit extract on the expression of transforming growth factor beta 1 in the tooth socket of diabetic Wistar rats
Authors: Luthfi Muhammad , Yuliati  , Wijayanti Elvina Hasna , Abdul Razak Fathilah Binti , Irmalia Wahyuning Ratih
Published: November 2021

Background:

Patients with diabetes mellitus suffer from an additional macrophage dysfunction in the secretion of growth factor, which later decreases transforming growth factor beta 1 (TGF-β1). This condition disrupts proliferation and angiogenesis. Extract of okra fruit (Abelmoschus esculentus) contains flavonoid, an active substance which acts as antioxidant, anti-inflammation, and antidiabetes. The purpose of this study is to analyze the difference in TGF-β1 expression in wound-healing process after tooth extraction of diabetic Wistar rats.

Materials and Methods:

This is a laboratory experimental study using pretest and posttest on 24 Wistar rats which are divided into two groups: control group (treated with streptozotocin induction but without administration of okra fruit extract) and treatment group (treated with streptozotocin induction and oral administration of 250 mg/kg okra fruit extract once a day). Extractions of the rats’ mandibular left incisors were performed using a pair of modified forceps and an elevator. The tooth sockets were then irrigated using saline solution. Four rats in each group were sacrificed on day 3 (KO1, PO1), 5 (KO2, PO2), and 7 (KO3, PO3). The socket tissues from the rats were then immunohistochemically analyzed. Data were analyzed at level significance of 0.05.

Results:

The average level of TGF-β1 expression in the treatment groups was higher compared to the control group: PO1 (11.59 ± 0.58), PO2 (15.15 ± 1.07), and PO3 (18.75 ± 2.73) as compared to KO1 (5.32 ± 1.69), KO2 (8.47 ± 0.60), and KO3 (9.28 ± 1.16) with P = 0.001.

Conclusion:

The administration of okra fruit extract can increase the level of TGF-β1 in wounds after tooth extraction of diabetic Wistar rats.
The clinical and radiographic evaluation of Allium sativum oil (garlic oil) in comparison with mineral trioxide aggregate in primary molar pulpotomy
Authors: Faghihi Taraneh , Haghgoo Roza , Taghizade Fateme , Zareiyan Mehrshad , Mehran Majid , Ansari Ghassem
Published: November 2021

Background:

Mineral trioxide aggregate (MTA) is known as a common biomaterial for pulpotomy of primary molars, with limitation including high cost, difficult handling, and long setting time. This study was conducted to compare the clinical and radiographic success rate of Allium sativum oil and MTA in pulpotomy of primary molar teeth.

Materials and Methods:

This randomized, controlled, clinical trial was performed on a group of children with at least two symptom-free primary molars requiring pulpotomy. A total of 90 teeth were randomly assigned into two groups: After pulp amputation and hemostasis, Group I received MTA as medication in the pulp chamber and Group II received Allium sativum oil over the pulp stumps. Pulp chamber was then filled with reinforced ZOE paste (zinc oxide eugenol) and teeth were restored using stainless steel crowns. The follow-up scheme of 6, 12, and 18 months was set, and teeth evaluation was conducted by a calibrated pediatric dentist based on the modified criteria proposed by Zurn and Seale. The results were analyzed using the generalized estimating equation analysis with the P = 0.05 as the level of significance.

Results:

The clinical success rate was 100% in both groups after all follow-ups. The radiographic success rate was, however, 91.1% after 6.75. 6% after 12 and 18 months in Group II while it was 95.6% after 6, 91.1% after 12 and 18 months in Group I in those follow-up points. The difference between the two groups was not statistically significant.

Conclusion:

According to the results, Allium sativum oil has a high clinical and radiographic success rate comparable to those of MTA.
Comparison of Adverse Events between Ramipril and Perindopril in Contemporary Cardiac Practice
Authors: Sankaran Ramesh , Senguttuvan Nagendraboopathy , Muralidharan Thoddi Ramamurthy , Balakrishnan Vinodkumar , Sadhanandham Shanmugasundaram , Panchanatham Manokar , Balasubramaniyan Jayanthy Venkata , Krishnamurthy Preetham , Badimela Phulgun
Published: November 2021

Background:

Angiotensin-converting enzyme inhibitors (ACEIs) are extensively used for the treatment and management of cardiovascular diseases. Although ACEIs are a well-tolerated medication in high percentage of patients, around 30% can develop adverse reactions like dry cough.

Objective:

The objective of the study was to capture the incidence of cough in patients with cardiovascular diseases that were prescribed with perindopril and ramipril in an Indian tertiary care hospital.

Methods:

In this observational study, the incidence of cough in patients with cardiovascular diseases that were prescribed with perindopril and ramipril was estimated.

Results:

A total of 223 patients were enrolled in this study. Around 50.67% patients received ramipril; among them, 6.02% received 1.25 mg, 78.95% received 2.5 mg, and 13.53% received 5 mg of ramipril. Around 35.9% (n = 80) patients received perindopril. In perindopril group, 31.3% of the patients received 2 mg dose and 68.8% of patients received 4 mg dose. Among perindopril group, the incidence of cough was observed in 10% (n = 8) of the patients, whereas in ramipril group, it was 19.55% (P = 0.00136). Due to cough, in perindopril group, 6.3% (5/80) of the patients discontinued treatment whereas in ramipril group, 9% (12/133) of the patients discontinued treatment medication.

Conclusions:

Our study has demonstrated that perindopril has been associated with a relatively low incidence of cough compared to ramipril.
Assessment of the Factors Influencing Dental Students to Choose Dentistry as a Career
Authors: Karagir Amol , Khairnar Mahesh Ravindra , Adaki Shridevi , Dhole Rohit Ishwar , Patil Madhuri C. , Ingale Amritha
Published: November 2021

Objective:

Career choice, one of the most important process in a student's life, has an influence on his/her future life. Hence, it is important to understand student's motives behind choosing a specific career. Hence, the study was designed with an aim to evaluate the factors influencing dental students to choose dentistry as career.

Methods:

The present cross-sectional survey was conducted on 401 dental students from a dental institute. The data was collected using a structured questionnaire consisting of 13 reasons that possibly influenced students' decision to study dentistry. Data collected was analyzed using SPSS 20 software.

Results:

Majority of the students participating were female (77.1%). Top four reasons to choose dentistry as a profession were to help poor people (95.5%), to earn prestige and respect (95.0%) followed by self-interest (94.7%) and study of human parts especially teeth (92.8%). Making money was the reason reported by 77.8% of the students. Other reasons reported were inspiration from other dentists (63.3%), did not get admission to medicine (MBBS) course (52.1%), and no doctor in family (51.9%). Family members in medical/dental profession was the least reported reason (36.9%). There were no significant differences among males and females for reported reasons except for one reason, that is, did not get admitted to medicine (MBBS) course (60.9% male and 48.9% female; P = 0.031).

Conclusion:

Students were mostly influenced by own interest and altruistic nature to opt for dental profession.
Influence of Volume of Endodontic Irrigants used in Different Irrigation Techniques on Root Canal Dentin Microhardness
Authors: Arul Buvaneshwari , Suresh Nandini , Sivarajan Ranjithkumar , Natanasabapathy Velmurugan
Published: November 2021

Introduction:

Overzealous application of endodontic irrigants affects the root canal dentin mechanical properties. The effect of volume of endodontic irrigants on the microhardness of root canal dentin has not been studied.

Aim:

This study assessed the effect of volume of endodontic irrigants used in different final irrigation activation techniques on root canal dentin microhardness (RCDM).

Methodology:

Sixty human maxillary central incisors were embedded in acrylic resin in Kuttler's endodontic cube to the level of cementoenamel junction. The root samples were randomly divided into 4 experimental groups (n = 15): Group-NI-needle irrigation, Group-PUI–continuous passive ultrasonic irrigation, Group-EndoVac–apical negative pressure system, Group combination– EndoVac + PUI irrigation. Root canals were instrumented up to size 40 (F4). The resin mounted specimens were sectioned longitudinally into two halves and were reassembled in Kuttler's kube to carry out final irrigation activation. A predetermined standardized volume of irrigants was used in each group. The RCDM was measured after root canal instrumentation and after final irrigation using Vicker microhardness tester (coronal, middle, and apical third). The reduction in RCDM values (P < 0.0086) were analyzed using Kruskal Wallis and Mann Whitney-U tests.

Results:

Reduction in RCDM was observed with all the endodontic irrigating techniques tested. EndoVac and combination irrigation techniques showed maximum reduction in RCDM in all thirds of root canal.

Conclusion:

It is concluded that the volume of irrigants and agitation plays a role in reducing RCDM. The overall volume of irrigants to cause maximum reduction was 25 ml, beyond which neither volume nor agitation affects RCDM.
Topological dynamics beyond Polish groups
Authors: Basso Gianluca , Zucker Andy
Published: November 2021

When

G

is a Polish group, metrizability of the universal minimal flow has been shown to be a robust dividing line in the complexity of the topological dynamics of

G

. We introduce a class of groups, the CAP groups, which provides a neat generalization of this to all topological groups. We prove a number of characterizations of this class, having very different flavors, and use these to prove that the class of CAP groups enjoys a number of nice closure properties. As a concrete application, we compute the universal minimal flow of the homeomorphism groups of several scattered topological spaces, building on recent work of Gheysens.
Transformées de Fourier des fonctions d’invariance hyperbolique sur $\mathbb{R}^2$
Authors: Clozel Laurent
Published: November 2021

On sait que sur

\R^n

la transformée de Fourier d’une fonction radiale est donnée par une tranformation de Hankel. On s’intéresse ici aux fonctions sur

\R^2

d’invariance hyperbolique, i.e. de la forme

f(x,y)=F(T)

,

T=\vert xy \vert

. Dans ce cas on montre, sous des hypothèses convenables, que la transformée de Fourier de

f

(vue comme une distribution) est donnée de même par une fonction

G(T)

, et que l’application

F \mapsto G

s’étend en une isométrie de

L^2(\R)

. Notre exposé simplifie et éclaire des résultats antérieurs.
Association between Hypertriglyceridemia and Disease Severity in Visceral Leishmaniasis
Authors: Varela Mariana Garcez , de Oliveira Bezerra Mariana , Santana Felipe Vieira , Gomes Marcos Couto , de Jesus Almeida Pedro Ribeiro , Silveira da Cruz Geydson , de Melo Enaldo Vieira , de Oliveira Costa Paulo Roberto , de Oliveira Fabrícia Alvisi , de Jesus Amélia Ribeiro , de Almeida Roque Pacheco
Published: November 2021

Visceral leishmaniasis (VL) is a tropical disease endemic to Brazil. The clinical manifestations of the infection range from asymptomatic to severe. In VL, changes in lipid metabolism, such as hypocholesterolemia and hypertriglyceridemia, occur that are believed to be related to its progression and severity. This study investigated the associations between serum levels of cholesterol, triglycerides, and lipoproteins (high-density lipoprotein, low-density lipoprotein, and very low-density lipoprotein) with clinical and hematological parameters that predict severity in a case series of 83 VL patients. Severely ill patients had higher mean serum triglyceride levels than non-severely ill patients. There was a significant positive correlation between disease severity score and serum triglyceride levels, very low-density lipoprotein, international normalized ratio for prothrombin time test, total bilirubin, and age. An inverse correlation was detected between the disease severity score and mean platelet and neutrophil counts. Hypertriglyceridemia can be a prognostic indicator of severity in patients diagnosed with VL.
Serological Evidence of Zika Virus Infection in Febrile Patients and Healthy Blood Donors in Sabah, Malaysian Borneo, 2017–2018
Authors: Ngwe Tun Mya Myat , Mori Daisuke , Sabri Shahnaz Binti , Kugan Omar , Shaharom Saliz Binti , John Jecelyn , Soe Aung Min , Nwe Khine Mya , Dony Jiloris Frederick , Inoue Shingo , Morita Kouichi , Ahmed Kamruddin
Published: November 2021

Several Zika virus (ZIKV) seroprevalence studies have been conducted in Africa, Asia, Oceania, the Americas, and the Caribbean. However, studies on ZIKV seroprevalence are limited in Malaysia though several studies have shown that the disease is endemic in the Malaysian state of Sabah. To evaluate the seroprevalence of ZIKV infection, 818 serum samples were collected from febrile patients and healthy blood donors from the Kudat and Kota Kinabalu districts in Sabah from 2017 to 2018. They were screened for ZIKV infection by IgM and IgG ELISA, and positive ZIKV IgM samples were subjected to a 90% neutralization test for confirmation. Twenty-four (6% [95% CI 4 to 8]) confirmed and two (0.5% [95% CI 0.13 to 1.8]) probable ZIKV infections were detected among 400 febrile illness patients. Of 418 healthy blood donor samples, six (1.4% [95% CI 0.65 to 3]) were determined as confirmed ZIKV infections and six (1.4% [95% CI 0.65 to 3]) indicated probable ZIKV infection. This is the first study on the seroprevalence of ZIKV infections among patients and healthy blood donors in Sabah. Compared with previous studies in Malaysia, this study shows that the incidence of ZIKV infection has increased. It also suggests that a sero-surveillance system is essential to determine the circulation of ZIKV in Sabah, Malaysia.
Rzekomy list księcia biskupa krakowskiego Kajetana Ignacego Sołtyka „z niewoli moskiewskiej” do Senatu i polskiego rządu
Authors: Krowicki Stanisław Ludwik
Published: November 2021

Artykuł dotyczy domniemanego listu senatora przedrozbiorowej Rzeczypospolitej, biskupa krakowskiego Kajetana Ignacego Sołtyka (1715–1788), skierowanego do kolegów senatorów oraz członków polskiego rządu. Prawdziwy autor listu nie jest znany, lecz z jego treści wnioskować można, iż leżały mu na sercu zmagania konfederatów barskich w latach 1768–1772 przeciwko rosyjskiej agresji w Polsce i na Litwie. Był zatem jednym z nich. Na ich opór bez wątpienia wpływ miała zarysowana w zaprezentowanym liście niezłomna postawa więzionego w Rosji biskupa Sołtyka i jego towarzyszy. Z mroków historii wydobyto w nim także pozytywnych bohaterów Polski i Litwy: św. Stanisława ze Szczepanowa, prymasa Jakuba Uchańskiego, hetmana Jana Karola Chodkiewicza, Radziwiłłów, księcia Jeremiego Michała Wiśniowieckiego, Jana III Sobieskiego, a nawet bohaterów starożytnego Rzymu. W rękopiśmiennych kopiach „List Biskupa Krakowskiego” był przechowywany po dworach szlacheckich, mając wpływ na patriotyczne postawy także następnych pokoleń młodzieży i będąc przyczyną wstępowania młodych ludzi w Polsce i na Litwie do oddziałów wojskowych walczących z Rosją. Letter presumed to be from the Bishop of Krakow “under Russian captivity” to the Polish Senate and Government This article concerns a letter presumed to be from a senator in the pre-Partition Commonwealth of Poland, the Bishop of Krakow, Kajetan Ignacy Sołtyk (1715–1788), addressed to his fellow senators and members of the Polish government. The real author of the letter is unknown, but its contents indicate that he felt strongly about the struggles of the Bar confederates in the years 1768–1772 against Russian aggression in Poland and Lithuania. Therefore, he was most likely one of them. Their resistance was certainly fuelled by the unyielding endurance under Russian captivity of Bishop Sołtyk and his companions, as outlined in the letter presented. It also entered the depths of history to find important figures from Poland and Lithuania, such as: Saint Stanislaus of Szczepanów, the Primate of Poland Jakub Uchański, Hetman Jan Karol Chodkiewicz, the Radziwiłłs, Prince Jeremi Michał Wiśniowiecki and John III Sobieski, and even ancient Roman heroes. Handwritten copies of the “Letter from the Bishop of Kraków” were kept at manor houses, serving to educate and inspire future generations in Poland and Lithuania to join military units to fight Russia.
Dokumentacja osobowo-płacowa do celów emerytalnych. Wskazówki dotyczące poszukiwań
Authors: Zięba Karolina
Published: November 2021

Archiwum Narodowe w Krakowie oprócz swoich statutowych zadań, polegających na kształtowaniu narodowego zasobu archiwalnego, przejmowaniu, przechowywaniu, opracowaniu, udostępnianiu i zabezpieczaniu matriałów archiwalnych, pełni także funkcję pomocniczą w zakresie informowania przyszłych emerytów na temat miejsc przechowywania dokumentacji osobowo-płacowej ze zlikwidowanych zakładów pracy. 244 Karolina Zięba Niniejszy artykuł omawia ogólne zasady, według których Zakład Ubezpieczeń Społecznych przyznaje świadczenia emerytalne. Potwierdzenie okresu zatrudnienia oraz złożenie kompletu dokumentacji niezbędnej do obliczenia kapitału początkowego ma tu kluczowe znaczenie. Były pracodawca wystawia druk RP-7, który stanowi zaświadczenie o zatrudnieniu i wynagrodzeniu. Jeśli jest to z jakichś przyczyn niemożliwe, przyszły emeryt poszukuje dokumentacji potwierdzającej fakt zaistnienia stosunku pracy oraz wysokość składek na własną rękę. Najbardziej interesującym z punktu widzenia wnioskodawców zagadnieniem jest problem odnalezienia miejsca przechowywania akt osobowo-płacowych. W zależności od specyfiki zakładu pracy będzie to inna instytucja. Zaprezentowano kilka wskazówek, odnośnie tego, czym należy się kierować w poszukiwaniach dokumentacji kadrowej. Omówiono także, skrótowo, znajdujące się w zasobie Archiwum Narodowego w Krakowie zespoły archiwalne, zawierające tego typu dokumentację, obalając popularne przekonanie, że akta osobowo-płacowe z terenu całej Polski (bądź ich dublety) są w jego posiadaniu.

Personnel documentation for retirement purposes. Tips concerning searches

The National Archives in Krakow, in addition to its statutory tasks of developing the national archival resources, acquiring, storing, mapping, providing access to and safeguarding archival materials, also provides help to future pensioners by supplying them with information concerning the storage locations of personnel documentation from workplaces that have closed down. This article discusses the general principles according to which the Social Insurance Organisation (ZUS) awards pensions. Confirmation of employment periods and the submittal of all documentation necessary for calculation of the initial capital is of great importance here. Former employers issue the RP-7 form, which represents a certificate of employment with remuneration levels. If, for some reason, this is impossible, the future pensioner looks for documentation confirming that the employment took place and the level of contributions. The most interesting issue for applicants concerns searching for the storage location of personnel records. The relevant institution depends on the type of workplace. A few tips are presented, with reference to the most important factors while searching for personnel documentation. There is also a brief discussion regarding the archival units found in the National Archives in Krakow that contain this type of documentation, disproving the popular belief that personnel records from all of Poland (or their copies) are in its possession.
Wizerunek herbu miasta Lublina w źródłach archiwalnych z XV–XVIII wieku
Authors: Trojanowska Maria
Published: November 2021

W artykule zostały zebrane i opisane źródła ikonograficzne do dziejów herbu miasta Lublina z XV–XVIII w. przechowywane w zasobie Archiwum Państwowego w Lublinie. Wizerunki tego herbu podzielono na trzy grupy w zależności od rodzaju źródła i miejsca występowania znaku. Należą do nich: wyobrażenia na pieczęciach miasta, superekslibrisy na oprawach ksiąg miejskich i zdobienia malarskie o tematyce heraldycznej występujące na kartach tych ksiąg. Najstarsze wizerunki herbu Lublina zachowały się na pieczęciach z początku XV w., które z uwagi na swój urzędowy charakter są też najcenniejszym źródłem heraldycznym. Przedstawiony na nich herb, zarówno w swojej budowie, jak i stylistyce rysunku, był akceptowanym przez władze miejskie znakiem miasta. Z kolei pierwsze barwne wyobrażenia herbu Lublina, ważne dla poznania barw heraldycznych, pochodzą dopiero z pierwszej połowy XVII w.

The Image of Lublin’s Coat of Arms in Archival Sources of 15th–18th Centuries

The article has collects and described iconographic fifteenth-eighteenth century sources to the history of the Lublin coat of arm, which are kept in the State Archive in Lublin. The images of the coat of arms have been divided into three groups depending on the sort of the source and the place of its occurrence. They include: images on the seals of the town, super-bookplates on the bindings of city registers, and heraldic painting decorations present on the pages of these volumes. The oldest images of the Lublin coat of arms were preserved on seals from the beginning of the fifteenth century which, considering their official character, are also the most precious heraldic source. The coat of arms presented on them, both in its structure and the style of the drawing was the mark of the city, accepted by its authorities. However, the first color images of Lublin’s coat of arms, important for recognizing heraldic colors, come from the first half of the eighteenth century.
Organizacja pracy kancelaryjnej Zarządu Miejskiego w Puławach w latach 1944–1950
Authors: Gałęzowska Katarzyna
Published: November 2021

Artykuł prezentuje zagadnienia związane z organizacją kancelarii Zarządu Miejskiego w Puławach w latach 1945–1950. Bazę źródłową stanowiły materiały archiwalne z zespołu Akta miasta Puław, znajdujące się w zasobie Archiwum Państwowego w Lublinie. Ich analiza pozwoliła na dokładne odtworzenie funkcjonowania kancelarii w okresie stosowania systemu dziennikowego, a od 1949 r. systemu bezdziennikowego. Unowocześnienie kancelarii było możliwe dzięki wprowadzeniu normatywów kancelaryjnych – instrukcji kancelaryjnej oraz rzeczowego wykazu akt, odbiegającego od powszechnie stosowanych wówczas wykazów strukturalno-rzeczowych.

Organization of the Work of the Administrative Office of the Town Government in Puławy in 1944–1950

The article presents the issues of the organization of the administrative office in the town government in Puławy in 1945–1950. The source materials are the archival materials from the records of the Town of Puławy (held in the State Archive in Lublin). Their analysis allowed the author to recreate precisely the functioning of the administrative office while using it used the register system and from 1949 – the case-based filing system. The modernization of the administrative office was possible due to the introduction of office standards – office instructions and the subject index of records, which was different from the commonly used structural-subject records.
Piętnaście lat digitalizacji w Archiwum Państwowym w Lublinie
Authors: Zawada Michał , Krzykała Marek
Published: November 2021

Archiwum Państwowe w Lublinie od 2002 r. digitalizuje archiwalia i jest jednym z pionierów w tym zakresie wśród archiwów państwowych. Lubelskie Archiwum nieustannie kontroluje proces digitalizacji w celu przystosowania go do rosnących wymogów społeczeństwa informacyjnego oraz realizacji misji trwałego zachowania świadectw przeszłości i zapewnienia do nich powszechnego dostępu w ramach wspierania rozwoju państwa i społeczeństwa obywatelskiego. Doświadczenie, które Archiwum zdobyło podczas 15 lat digitalizacji swego zasobu, jest wynikiem dobrze określonych zasad na szczeblu Naczelnej Dyrekcji i konsekwentnej ich realizacji przez dyrekcję i pracowników Archiwum. Realizując cele digitalizacji archiwaliów, lubelskie Archiwum może się szczycić pokaźnym wkładem w cyfrowe zabezpieczanie i udostępnianie zasobu archiwalnego.

Fifteen years of digitization in The State Archive in Lublin

The State Archive in Lublin is digitizing archival materials since year 2002 and is still one of pioneers among state archives in this matter. The State Archive in Lublin is continuously controlling process of digitization accepted in its organizational structures in attempt to adjust this process to constantly evolving demands of digital world and informative society. Thanks to this fact Archive provides fulfillment to archival mission of persistent preservation of past testimonies and guarantee of common access to them for the purpose of support for development of The State and of informative society. Experience gained by The State Archive in Lublin during 15 years of digitization of its own fonds is a result of clearly specified rules from Chief Directorate and constructive implementation of these by Directorate and employees of Archive responsible for process of digitization. Fulfilling goals of digitization of archives – from determining hardware and personnel needs, through progress of digitization process, to theoretical thoughts on accurate digital representations of records – Archive in Lublin can rightly be proud of its substantial contribution into digital preservation and access to archival fonds.
Jan Andrzej Sierakowski i jego „Konnotata prywatne”
Authors: Janas Eugeniusz
Published: November 2021

Zasadniczą częścią artykułu jest edycja krótkiego dziełka pamiętnikarskiego z drugiej połowy XVII w., należącego niewątpliwie do gatunku rodzinnych raptularzy, popularnych zwłaszcza w piśmiennictwie szlacheckim XVII–XVIII w. Tekst pióra Jana Andrzeja Sierakowskiego (zm. 1698 r.) jest rzeczowym i lapidarnym zapisem wydarzeń z lat 1664–1697, przede wszystkim prywatnych i rodzinnych, dotyczących także działalności publicznej autora, również jego rozlicznych transakcji, głównie natury majątkowej. Raptularz wydaje się interesującym świadectwem szlacheckiego żywota i codzienności. Edycję poprzedza krótki wywód historii rodu Sierakowskich, w głównej mierze zaś autora owego tekstu.

Jan Andrzej Sierakowski and His Private Diaries

The main part of this article is the edition of a short diary from the second part of seventeenth century which undoubtedly belongs to the genre of family memoirs so popular in the nobility writings of the seventeenth and eighteenth century. The text, written by Jan Andrzej Sierakowski (died in 1698), is a factual and concise history of events from 1664–1697; first of all it concerns private and family history but also pertains to the public activity of the author and his numerous mainly property) transactions. The diary seems an interesting item of evidence of the nobility’s everyday life. The edition is preceded by a short history of Sierakowski family, especially regarding the author of the text.
Dokumenty potwierdzenia praw miejskich Firleja
Authors: Seroka Henryk
Published: November 2021

Miasto Firlej w województwie lubelskim – w XVI–XVIII w. noszące nazwę Firlejów – według dawnej literatury historycznej lokowane było w 1557 r. dzięki staraniom Mikołaja Firleja. Przywilej lokacyjny tego miasta nie jest znany, jedynie wzmianki z dawnego archiwum skarbowego oraz ksiąg miejskich pobliskiego Lubartowa z II połowy XVI w. poświadczają istnienie tego miasta. Dokumenty potwierdzające lokację miasta i nadanie mu prawa miejskiego pochodzą z XVII i XVIII w. Prawo miejskie Firleja w 1688 r. potwierdził ówczesny właściciel miasta Józef Karol Lubomirski. Kolejny dziedzic miasta Paweł Karol Sanguszko wydał dwa dokumenty potwierdzające prawa miejskie Firleja – w 1712 i 1739 r. W świetle tych dokumentów oraz ksiąg miejskich Firlejowa miasto funkcjonowało według norm prawa miejskiego magdeburskiego od około 1690 r.

Documents of Confirmation of Town Rights of Firlej

Firlej, a town in Lublin province, was called between the sixteenth and eighteenth centuries after the Firlej family. According to historical literature it was founded in 1557 due to the endeavors of Mikołaj Firlej. The foundation charter is not known; only some references from the Treasury Archive and town books of the nearby Lubartów of the second half of the 16th century confirm the existence of this town. The documents which attest to the foundation of the town and granting a foundation charter come from the seventeenth and eighteenth centuries. The then owner of the town, Józef Karol Lubomirski, confirmed the town rights of Firlej in 1688. The subsequent heir of the town, Paweł Karol Sanguszko, 13 H. Seroka, Firlejów, s. 18–19, 23–24. Dokumenty potwierdzenia praw miejskich Firleja 173 issued two documents which certified the town rights of Firlej in 1712 and 1739. According to these documents and the town books of Firlej, the town operated under the Magdeburg town law since circa 1690.
O mestre, a obra e o amigo:
Authors: Rocha Everardo
Published: November 2021

Iniciar um texto em homenagem ao professor José Carlos Rodrigues poderia ser a partir de qualquer uma das diversas possibilidades que, em nossos mais de quarenta anos de convivência, ele descortinou para mim, seja como amigo, colega de departamento, professor, coautor ou, principalmente, como importante referência bibliográfica em minha formação. Escolho, portanto, esta última, pois sua obra acadêmica e seu projeto intelectual foram essenciais para meu próprio trabalho, bem como para centenas de outros pesquisadores que puderam conhecer seus inspiradores estudos.
METHODS AND MEANS OF INCREASING THE ACCURACY OF DETERMINING THE STATE OF THE OBJECT
Authors: BEKİROVA Lala , BUNYATOVA Elvira
Published: November 2021

In order to determine the state of the object, the distance to it, inclination, density, etc. various types of sensors setting parameters with high accuracy, as well as methods and means to increase the accuracy of setting these parameters are presented in the article. The types of the presented sensors, the principles of operation, areas of application have been comparatively analyzed, their classification has been considered and their pros and cons have been analyzed. Among the considered methods, a complex method with laser sensors, which is an expedient method for determining the distance to the object with high accuracy, has been proposed, the principle-structural model, areas of application, features, advantages and disadvantages of the functional model have been analyzed. The proposed method with high temperature stability determines the distance to the object, inclination, density, etc. the possibility of measurement is shown. The optical system, which uses a laser source and sensors being capable of taking measurements in the visible range, is accompanied by perfect control based on sensor circuits and processing microcontrollers to achieve optimal results in the complex measurement and control process that allows determining the characteristic parameters with high accuracy that set the state of a high object.
Evaluación de las necesidades educativas en pacientes con osteoartritis de rodilla en una cohorte latinoamericana
Authors: Fajardo Estefania
Published: November 2021

Los artículos de la revista estarán disponibles en español, inglés y portugués con el objetivo de llegar a todos y reconocer la importancia de la investigación y ciencia que se hace en nuestra región.
PROBLEMATIKA PARTISIPASI PEMILIH PENYANDANG DISABILITAS DALAM PEMILIHAN SERENTAK LANJUTAN 2020
Authors: Viera Mayasari Sri Rengganis  , Hadi Ismail Sidiki  , Fajar Saputra  , Winengku Damarjati
Published: November 2021

Sebuah aspek penting yang tidak cukup memperoleh perhatian para pengamat dan peneliti dalam Pemilihan Serentak Lanjutan 2020 adalah partisipasi pemilih penyandang disabilitas. Masih diperlukan upaya akademik yang sungguh-sungguh untuk menjawab pertanyaan: problematika apa saja yang muncul dalam partisipasi pemilih penyandang disabilitas di Indonesia? Tulisan ini menjawab pertanyaan tersebut dengan mengambil lokasi penelitian di empat kabupaten, yaitu Sleman, Bantul, Bulungan, dan Kutai Kartanegara. Penelitian ini membahas strategi dan kebijakan yang telah dilakukan oleh Komisi Pemilihan Umum (KPU) di masing-masing kabupaten, serta problematika yang ditemui berkaitan dengan partisipasi pemilih penyandang disabilitas. Tulisan ini menggunakan metode kualitatif berupa studi kasus. Teknik pengumpulan data dilakukan dengan wawancara dengan Ketua dan Anggota KPU di masing-masing lokasi penelitian dan perwakilan organisasi penyandang disabilitas. Sedangkan data sekunder diperoleh dari buku, jurnal, regulasi, dan keputusan internal KPU. Kesimpulan yang diperoleh yaitu terdapat upaya pemenuhan hak politik bagi penyandang disabilitas pada 4 (empat) lokasi penelitian, dimulai dari pendataan sampai dengan penyediaan Tempat Pemungutan Suara (TPS) yang mudah diakses. Selain itu, penyandang disabilitas telah berpartisipasi secara aktif dengan memilih pemimpin secara langsung. Namun masih terdapat permasalahan yang dapat diklasifikasikan kedalam empat hal yaitu (1) sosialisasi politik; (2) demand and support; (3) data penyandang disabilitas; dan (4) aksesibilitas.
Statehood: the Essential Prerequisite for Law and Liberty
Authors: Laughland John
Published: November 2021

The attempt to subject Poland and Hungary to procedures under EU law for allegedly not respecting European values has its roots both in the supranational nature of the EU project and also in the differing concepts of the nation in the Eastern and Western halves of the continent.  The hegemonic West is deeply post-modern while former Communist states have retained some faith in the nation.  Globalisation generally, and the EU project in particular, are based on functionalist assumptions whose origins lie in the early 19th century, yet these fail to understand the eminently political nature of law: all jurisdictions are rooted in society and the state and it is the role of government to adjudicate between the competing claims of citizens.  This makes it very difficult, impossible even, to formulate universal rights since their formulation and application depend on interpretation, i.e. on jurisdiction, and therefore on the sovereignty of the ultimate decision-maker.
Some Values and Guarantees in the Ten-Year-Old Hungarian Constitution, With a Look at the Constitutional Arrangements of the Countries Founding the European Integration
Authors: Szilágyi János Ede
Published: November 2021

In this study, certain values and guarantee institutions of the Hungarian Fundamental Law are analysed in the light of the constitutions of the countries that have established European integration – Germany, France, Italy, and Belgium. Among the value systems, Christian culture and the family have been examined, while the study has also focused on the guarantees important for living conditions, such as strict public finance provisions, rules on emergency powers, and provisions guaranteeing a high level of protection for future generations and the environment. In addition to the analysis of the constitutions, the study makes several references to the jurisprudence of the countries concerned and to the most important aspects of constitutional developments in recent years.
Summary of the ‘Dialogue on the Future of Europe: Building a Digital European Union’ Conference Organised by the Ministry of Justice and the Ferenc Mádl Institute of Comparative Law as Part of the ‘Conference on the Future of Europe’ Series
Authors: Bólya Boglárka , Gát Bence Ákos , Kilényi Olivér Márk , Kiss Lilla Nóra , Marik Helga , Vajas Anna , Dornfeld László
Published: November 2021

On June 21, 2021, the Hungarian Ministry of Justice (Deputy State Secretariat for EU Relations) and the Ferenc Mádl Institute of Comparative Law (MFI) organised a high-profile international conference entitled ‘Dialogue on the Future of Europe: Building a Digital European Union’ as part of a series in which two previous conferences were held on June 25 and September 21, 2020. By organising these events, Hungary is among the first Member States to launch a dialogue as part of a series of discussions on the future of Europe. As a proactive actor, Hungary has contributed to the ongoing exchange of views offering a comprehensive assessment of and approach to the digital developments and perspectives of the European Union. The June 21, 2021 conference – composed of three thematic panel discussions – focused on the future of digitalisation and competitiveness in the European Union. Highly accomplished national speakers such as Hungarian Minister of Justice Judit Varga and Hungarian Member of Parliament and President of the Economic Committee Erik Bánki and international speakers such as Commissioner Mariya Gabriel and State Secretary Ana Paula Zacarias gave presentations outlining their visions. This article summarizes those presentations. In addition to public officials and economic actors, academic experts and researchers on digital transition also gave presentations at the conference. The conclusions drawn from their exchanges of views seek to contribute to the creation of sensible decisions leading towards a digital future, while also raising public awareness regarding digitalisation, a realm of growing influence on policymaking.
Area, Extent, and Restriction of Fundamental Rights During the Special Legal Order, with Exceptional Regard to the Epidemiological Situation in the Territory of the Slovak Republic
Authors: Kaščák Dávid
Published: November 2021

The Slovak Republic, as other countries around the world, was affected by the coronavirus pandemic in the first half of 2020. This epidemiological situation has had a substantial social impact on the basis of which it was necessary to take measures that affected the daily lives of individuals. To prevent the spread of the coronavirus, states have often been forced to apply restrictions that were on the verge of acceptance in terms of respect for fundamental rights. Interference with such sensitive issues as fundamental rights and the adaptation of urgent and immediate measures to minimise the spread of the coronavirus had to be effective and conform to the requirements of balance and mutual proportionality. In 2020, the Slovak Republic, as many countries, faced difficulties in the fight against the coronavirus. This paper focuses on this global problem, the steps taken by government officials in the Slovak Republic, and the theoretical basis for respecting and exercising fundamental rights in this area. The aim of the introduction of this professional article is to present the anchoring of fundamental rights and freedoms in the context of revolutionary events. The purpose of the remaining portions of this expert article is to explain and analyse the related and most discussed legal facts that have had a social impact following the discovery of the coronavirus in the Slovak Republic. An additional intention is to elucidate and generalise the solutions that have been introduced in the fight against the pandemic while noting the actual steps taken by the government over time.
Strahlenimmunbiologie – das neue immunmodulierende Bild von Strahlung
Authors: Gaipl Udo S.
Published: November 2021

Nach der Entdeckung der Röntgenstrahlung 1895 wurde diese rasch für diagnostische und therapeutische Zwecke genutzt. Die DNA ist die strahlensensibelste Struktur der Zelle, aber ionisierende Strahlung induziert auch generelle Stressantworten. Hierbei verändert sich der immunologische Phänotyp der Zellen sowie deren Mikroumgebung. Dies kann, in Abhängigkeit der verwendeten Strahlendosis und insbesondere in Kombination mit weiteren Immunmodulatoren, zu lokalen und systemischen Anti-Tumor-Immunantworten führen oder Entzündungen abmildern. In diesem Artikel wird das Forschungsfeld der Strahlenimmunbiologie vorgestellt, die in den letzten Jahren enthüllten Mechanismen der Immunmodulation durch Strahlung im Kontext der Behandlung von malignen und benignen Erkrankungen behandelt sowie die Herausforderungen für die Zukunft aufgezeigt.