bluuebunny/crossref_metadata_2025 huggingface dataset:
Biomimetic Cu/Nitroxyl Catalyst Systems for Selective Alcohol Oxidation
Authors: Marais Lindie , Swarts Andrew John
Published: April 2019

The oxidation of alcohols to the corresponding carbonyl products is an important organic transformation and the products are used in a variety of applications. The development of catalytic methods for selective alcohol oxidation have garnered significant attention in an attempt to find a more sustainable method without any limitations. Copper, in combination with 2,2,6,6-tetramethyl-1-piperidine N-oxyl (TEMPO) and supported by organic ligands, have emerged as the most effective catalysts for selective alcohol oxidation and these catalyst systems are frequently compared to galactose oxidase (GOase). The efficiency of GOase has led to extensive research to mimic the active sites of these enzymes, leading to a variety of Cu/TEMPO· catalyst systems being reported over the years. The mechanistic pathway by which Cu/TEMPO· catalyst systems operate has been investigated by several research groups, which led to partially contradicting mechanistic description. Due to the disadvantages and limitations of employing TEMPO· as co-catalyst, alternative nitroxyl radicals or in situ formed radicals, as co-catalysts, have been successfully evaluated in alcohol oxidation. Herein we discuss the development and mechanistic elucidation of Cu/TEMPO· catalyst systems as biomimetic alcohol oxidation catalysts.
Perception of Climate Change Risk and Adaptation in the Czech Republic
Authors: Krkoška Lorencová Eliška , Loučková Blanka , Vačkářů Dava
Published: April 2019

Public perception of climate change is an important element that affects attitudes towards adaptation and mitigation. Understanding the general public’s perception of the issue can assist decision-makers, though the climate change perception is affected by multiple factors. This study examines the main sociodemographic factors, including gender, and the role of previous personal experience with extreme weather events on climate change perception and engagement in individual adaptation and mitigation actions among the general population in the Czech Republic. Based on statistical analysis, gender, age and previous experience with extreme weather events have been found to play a significant role in the climate change beliefs of individuals and in the perception of the cause of the changing climate. The analysis revealed that respondents with previous experience with extreme weather events were significantly more likely to implement adaptation and mitigation actions than respondents with no experience. The survey represents insights into climate change perception and beliefs of the general public at the national level.
In-Vivo Corrosion Characterization and Assessment of Absorbable Metal Implants
Authors: Ulum Mokhamad Fakhrul , Caesarendra Wahyu , Alavi Reza , Hermawan Hendra
Published: April 2019

Absorbable metals have been introduced as materials to fabricate temporary medical implants. Iron, magnesium and zinc have been considered as major base elements of such metals. The metallurgical characterization and in-vitro corrosion assessment of these metals have been covered by the new ASTM standards F3160 and F3268. However, the in-vivo corrosion characterization and assessment of absorbable metal implants are not yet well established. The corrosion of metals in the in-vivo environment leads to metal ion release and corrosion product formation that may cause excessive toxicity. The aim of this work is to introduce the techniques to assess absorbable metal implants and their in-vivo corrosion behavior. This contains the existing approaches, e.g., implant retrieval and histological analysis, ultrasonography and radiography, and the new techniques for real-time in-vivo corrosion monitoring.
Laser-Sustained Plasma (LSP) Nitriding of Titanium: A Review
Authors: Kamat Amar M. , Copley Stephen M. , Segall Albert E. , Todd Judith A.
Published: April 2019

Titanium and its alloys possess several attractive properties that include a high strength-to-weight ratio, biocompatibility, and good corrosion resistance. However, due to their poor wear resistance, titanium components need to undergo surface hardening treatments before being used in applications involving high contact stresses. Laser nitriding is a thermochemical method of enhancing the surface hardness and wear resistance of titanium. This technique entails scanning the titanium substrate under a laser beam near its focal plane in the presence of nitrogen gas flow. At processing conditions characterized by low scan speeds, high laser powers, and small off-focal distances, a nitrogen plasma can be struck near the surface of the titanium substrate. When the substrate is removed, this plasma can be sustained indefinitely and away from any potentially interacting surfaces, by the laser power and a cascade ionization process. This paper presents a critical review of the literature pertaining to the laser nitriding of titanium in the presence of a laser-sustained plasma, with the ultimate objective of forming wide-area, deep, crack-free, wear-resistant nitrided cases on commercially pure titanium substrates.
Using Cognitive Behavioural Techniques to Improve Academic Achievement in Student-Athletes
Authors: Firth-Clark Andrea , Sütterlin Stefan , Lugo Ricardo Gregorio
Published: April 2019

Improving academic grades within the core areas of English, Science and Mathematics has had a lot of previous research interest, but research has tended to mostly focus on students who are failing, non-athletically talented students or student athletes at collegiate level. The particular needs of athletically talented secondary school students who are academically underperforming have so far been neglected. This study addressed this issue by measuring the outcome of academic grades in these three core areas. Method: During a six week intervention programme, ninety four students were separated into 4 groups: control, heart rate variability biofeedback, performance psychology skills training and a combination of these two interventions. Changes in self-efficacy and self-regulation for all students were also measured. Results: Significant pre–post intervention differences in all academic subjects and generalised self-efficacy were found when compared to the control group. Results also showed that a combination of interventions with medium–large effect size was more effective in improving academic results than the single interventions on their own. All interventions improved self-efficacy, but were not significantly different from each other. Self-efficacy was found not to have any interaction effects. Conclusion: Sport psychological skills training can help student-athletes achieve higher scholastic grades and aid mindfulness intervention. Mindfulness on its own was not found to be the most effective intervention, and as such should be used as an adjunct to other psychological methods. Psychological skills training (PST) may help students generalize approaches used in sport to the academic arena.
Enhancing Line Capacity Utilization in Power Transmission System Using Active MVDC Link
Authors: Han Changhee , Song Sungyoon , Kim Juyong , Jang Gilsoo
Published: April 2019

As a proportion of generation using renewable energy increases in a power system, the need for facility investment is increasing in not only the distribution system but also the transmission system. However, it is inefficient to invest in new equipment to deal with the short peak output of renewable energy generation. For this reason, this paper proposes a method for operating the grid more flexibly, through an optimal operating strategy of the direct current (DC) line at medium-voltage (MV) level, thereby delaying the facility investment in the transmission line. In order to determine the optimal operating point of the converter connected with a DC line, the swarm intelligence-based optimization technique, which can minimize multi-objective function, is used. In addition, in order to overcome the communication dependency of the centralized control, which needs to receive information about the optimal operating point computed by the system operator, this paper proposes a decentralized emergency control (DEC) method in case of a communication fault.
Real-Time Monitoring of Passenger’s Psychological Stress
Authors: Vila Gaël , Godin Christelle , Sakri Oumayma , Labyt Etienne , Vidal Audrey , Charbonnier Sylvie , Ollander Simon , Campagne Aurélie
Published: April 2019

This article addresses the question of passengers’ experience through different transport modes. It presents the main results of a pilot study, for which stress levels experienced by a traveller were assessed and predicted over two long journeys. Accelerometer measures and several physiological signals (electrodermal activity, blood volume pulse and skin temperature) were recorded using a smart wristband while travelling from Grenoble to Bilbao. Based on user’s feedback, three events of high stress and one period of moderate activity with low stress were identified offline. Over these periods, feature extraction and machine learning were performed from the collected sensor data to build a personalized regressive model, with user’s stress levels as output. A smartphone application has been developed on its basis, in order to record and visualize a timely estimated stress level using traveler’s physiological signals. This setting was put on test during another travel from Grenoble to Brussels, where the same user’s stress levels were predicted in real time by the smartphone application. The number of correctly classified stress-less time windows ranged from 92.6% to 100%, depending on participant’s level of activity. By design, this study represents a first step for real-life, ambulatory monitoring of passenger’s stress while travelling.
Evaluation of Environmental Contamination and Estimated Radiation Exposure Dose Rates among Residents Immediately after Returning Home to Tomioka Town, Fukushima Prefecture
Authors: Matsuo Masahiko , Taira Yasuyuki , Orita Makiko , Yamada Yumiko , Ide Juichi , Yamashita Shunichi , Takamura Noboru
Published: April 2019

On 1 April 2017, six years have passed since the Fukushima Daiichi Nuclear Power Station (FDNPS) accident, and the Japanese government declared that some residents who lived in Tomioka Town, Fukushima Prefecture could return to their homes. We evaluated environmental contamination and radiation exposure dose rates due to artificial radionuclides in the livelihood zone of residents (living space such as housing sites), including a restricted area located within a 10-km radius from the FDNPS, immediately after residents had returned home in Tomioka town. In areas where the evacuation orders had been lifted, the median air dose rates were 0.20 μSv/h indoors and 0.26 μSv/h outdoors, and the radiation exposure dose rate was 1.6 mSv/y. By contrast, in the “difficult-to-return zone,” the median air dose rate was 2.3 μSv/h (20 mSv/y) outdoors. Moreover, the dose-forming artificial radionuclides (radiocesium) in the surface soil were 0.018 μSv/h (0.17 mSv/y) in the evacuation order-lifted areas and 0.73 μSv/h (6.4 mSv/y) in the difficult-to-return zone. These findings indicate that current concentrations of artificial radionuclides in soil samples have been decreasing in the evacuation order-lifted areas of Tomioka town; however, a significant external exposure risk still exists in the difficult-to-return zone. The case of Tomioka town is expected to be the first reconstruction model including the difficult-to-return zone.
Associations of Class-Time Sitting, Stepping and Sit-to-Stand Transitions with Cognitive Functions and Brain Activity in Children
Authors: Mazzoli Emiliano , Teo Wei-Peng , Salmon Jo , Pesce Caterina , He Jason , Ben-Soussan Tal Dotan , Barnett Lisa M.
Published: April 2019

Previous research showed that children’s physical activity is positively related to executive functions, whilst screen time shows negative associations. However, it is unclear how school-based sitting time and transitions from sitting to standing relate to cognition. We investigated the relationship between class time sitting/stepping/sit-to-stand transitions and cognitive functions in Grade 1–2 children. Overall, 149 children (7.7 ± 0.6 years old, 54% boys) participated. Measures included class time sitting/stepping/sit-to-stand transitions and: (i) response inhibition (i.e., response time and accuracy); (ii) lapses of attention; (iii) working memory; and (iv) brain activity (cortical haemodynamic response). Linear mixed-models, adjusting for age, sex, and clustering at the classroom level, found that more sitting time was associated with higher lapses of attention (β = 0.12, p < 0.05). Children who stepped more had quicker inhibition response time (β = −0.95, p < 0.01); however, they were less accurate in their responses (β = −0.30, p < 0.05) and this was also observed with sit-to-stand transitions (β = −0.26, p < 0.05). No associations were found with brain activity. In conclusion, reducing and breaking up sitting may help keep children focused, but the evidence regarding response inhibition is unclear.
Self-Assembled Supramolecular Ribbon-Like Structures Complexed to Single Walled Carbon Nanotubes as Possible Anticancer Drug Delivery Systems
Authors: Jagusiak Anna , Chłopaś Katarzyna , Zemanek Grzegorz , Jemioła-Rzemińska Małgorzata , Piekarska Barbara , Stopa Barbara , Pańczyk Tomasz
Published: April 2019

Designing an effective targeted anticancer drug delivery method is still a big challenge, since chemotherapeutics often cause a variety of undesirable side effects affecting normal tissues. This work presents the research on a novel system consisting of single walled carbon nanotubes (SWNT), dispersed with Congo Red (CR), a compound that forms self-assembled ribbon-like structures (SRLS) and anticancer drug doxorubicin (DOX). SWNT provide a large surface for binding of planar aromatic compounds, including drugs, while CR supramolecular ribbon-like assemblies can be intercalated by drugs, like anthracycline rings containing DOX. The mechanism of interactions in SWNT–CR–DOX triple system was proposed based on electrophoretic, spectral, Dynamic Light Scattering and scanning electron microscopy analyzes. The profile of drug release from the investigated system was evaluated using dialysis and Differential Scanning Calorimetry. The results indicate that ribbon-like supramolecular structures of CR bind to SWNT surface forming SWNT–CR complexes which finally bind DOX. The high amount of nanotube-bound CR greatly increases the capacity of the carrier for the drug. The high capacity for drug binding and possible control of its release (through pH changes) in the analyzed system may result in prolonged and localized drug action. The proposed SWNT–CR–DOX triple system meets the basic criteria that justifies its further research as a potential drug carrier.
Responses of the Photosynthetic Electron Transport Reactions Stimulate the Oxidation of the Reaction Center Chlorophyll of Photosystem I, P700, under Drought and High Temperatures in Rice
Authors: Wada Shinya , Takagi Daisuke , Miyake Chikahiro , Makino Amane , Suzuki Yuji
Published: April 2019

It is of interest how photosynthetic electron transport (PET) reactions respond to excess light energy caused by the combination of drought stress and high temperatures. Since such information is scarcely available for photosystem I (PSI), this question was explored in rice (Oryza sativa L.) plants subjected to drought stress, using culture solutions that contain poly(ethylene glycol) at different concentrations under two day/night temperature regimes. At 27/22 °C (day/night), drought stress led to the oxidation of the reaction center of the chlorophyll of PSI (P700), and also led to decreases in the quantum efficiencies of photosystem II (PSII) and PSI, and a reduction of the primary quinone electron acceptor of PSI. Such drought stress responses were wholly stimulated at 35/30 °C. These parameters were strongly correlated with each other and were minimally affected by temperature. These results indicate that the drought stress responses of the respective PET reactions are closely associated with each other in the oxidization of P700 and that such responses are stimulated at high temperatures. The underlying mechanisms of these phenomena were discussed. While P700 oxidation is thought to suppress reactive oxygen species (ROS) production, PSI photoinhibition was observed under severe stress conditions, implying that P700 oxidation is not sufficient for the protection of PSI under drought stress.
Mortalin (GRP75/HSPA9) Promotes Survival and Proliferation of Thyroid Carcinoma Cells
Authors: Starenki Dmytro , Sosonkina Nadiya , Hong Seung-Keun , Lloyd Ricardo V. , Park Jong-In
Published: April 2019

We previously reported that upregulation of mortalin (HSPA9/GRP75), the mitochondrial HSP70 chaperone, facilitates tumor cell proliferation and survival in human medullary thyroid carcinoma (MTC), proposing mortalin as a novel therapeutic target for MTC. In this report, we show that mortalin is also upregulated in other thyroid tumor types, including papillary thyroid carcinoma (PTC), follicular thyroid carcinoma (FTC), and anaplastic thyroid carcinoma (ATC), and that mortalin depletion can effectively induce growth arrest and cell death in human PTC (TPC-1), FTC (FTC133), and ATC (8505C and C643) cells in culture. Intriguingly, mortalin depletion induced varied effects on cell cycle arrest (G0/G1 phase arrest in TPC-1 and C643, G2/M phase arrest in 8505C, and mild G2/M phase arrest with increased sub-G0/G1 population in FTC133) and on the levels of TP53, E2F-1, p21CIP1, p27KIP1, and poly (ADP-ribose) polymerase cleavage in these cells, suggesting that thyroid tumor cells respond to mortalin depletion in a cell type-specific manner. In these cells, we also determined the efficacy of triphenyl-phosphonium-carboxy-proxyl (Mito-CP) because this mitochondria-targeted metabolism interfering agent exhibited similar tumor suppressive effects as mortalin depletion in MTC cells. Indeed, Mito-CP also induced robust caspase-dependent apoptosis in PTC and ATC cell lines in vitro, exhibiting IC50 lower than PLX4032 in 8505C cells and IC50 lower than vandetanib and cabozantinib in TPC-1 cells. Intriguingly, Mito-CP-induced cell death was partially rescued by mortalin overexpression, suggesting that Mito-CP may inactivate a mechanism that requires mortalin function. These findings support the significance of mortalin and mitochondrial activity in a broad spectrum of thyroid cancer.
Retinoic Acid Induces Differentiation of Mouse F9 Embryonic Carcinoma Cell by Modulating the miR-485 Targeting of Abhd2
Authors: Yu Mengying , Zhang Lei , Liu Yingxiang , Liu Defu , Guo Zekun
Published: April 2019

Retinoic acid (RA) plays a key role in pluripotent cell differentiation. In F9 embryonic carcinoma cells, RA can induce differentiation towards somatic lineages via the Ras-extracellular signal-regulated kinase (Ras/Erk) pathway, but the mechanism through which it induces the Erk1/2 phosphorylation is unclear. Here, we show that miR-485 is a positive regulator that targets α/β-hydrolase domain-containing protein 2 (Abhd2), which can result in Erk1/2 phosphorylation and triggers differentiation. RA up-regulates miR-485 and concurrently down-regulates Abhd2. We verified that Abhd2 is targeted by miR-485 and they both can influence the phosphorylation of Erk1/2. In summary, RA can mediate cell differentiation by phosphorylating Erk1/2 via miR-485 and Abhd2.
Optimizing Parallel Collaborative Filtering Approaches for Improving Recommendation Systems Performance
Authors: Sardianos Christos , Ballas Papadatos Grigorios , Varlamis Iraklis
Published: April 2019

Recommender systems are one of the fields of information filtering systems that have attracted great research interest during the past several decades and have been utilized in a large variety of applications, from commercial e-shops to social networks and product review sites. Since the applicability of these applications is constantly increasing, the size of the graphs that represent their users and support their functionality increases too. Over the last several years, different approaches have been proposed to deal with the problem of scalability of recommender systems’ algorithms, especially of the group of Collaborative Filtering (CF) algorithms. This article studies the problem of CF algorithms’ parallelization under the prism of graph sparsity, and proposes solutions that may improve the prediction performance of parallel implementations without strongly affecting their time efficiency. We evaluated the proposed approach on a bipartite product-rating network using an implementation on Apache Spark.
Thermal Death Kinetics of Cryptolestes pusillus (Schonherr), Rhyzopertha dominica (Fabricius), and Tribolium confusum (Jacquelin du Val) Using a Heating Block System
Authors: Hou Lixia , Wu Yi , Wang Shaojin
Published: April 2019

Thermal treatment has been extensively used to control pests in stored grains for a long time. The objective of this study was to analyze thermal death kinetics of adult flat grain beetle, Cryptolestes pusillus (Schonherr), lesser grain borer, Rhyzopertha dominica (Fabricius), and confused flour beetle, Tribolium confusum (Jacquelin du Val), using a heating block system (HBS), at temperatures of 46, 48, 50, and 52 °C for C. pusillus and T. confusum, and 48, 50, 52, and 54 °C for R. dominica with a heating rate of 5 °C/min. Thermal death curves of those three insects followed a 0th-order reaction model. Complete mortality of C. pusillus, R. dominica, and T. confusum were observed after exposure to 1.4, 5.0, and 0.9 min at 52, 54 and 52 °C, respectively. The thermal death activation energy for controlling C. pusillus, R. dominica, and T. confusum was 689.91, 380.88, and 617.08 kJ/mol with z values of 2.88, 5.18, and 3.22 °C, respectively. The cumulative lethal time model can also be used to predict mortality of these three insects during a practical heating process. The information provided by this study on storage pests may be useful for developing effective thermal treatment protocols.
Abnormal Brain-Derived Neurotrophic Factor Exon IX Promoter Methylation, Protein, and mRNA Levels in Patients with Major Depressive Disorder
Authors: Hsieh Men-Ting , Lin Chin-Chuen , Lee Chien-Te , Huang Tiao-Lai
Published: April 2019

Brain-derived neurotrophic factor (BDNF) exon IX promoter methylation levels, serum BDNF protein levels, and serum mRNA levels were investigated in patients with major depressive disorder (MDD) and healthy controls. Over two years, 51 patients with MDD and 62 healthy controls were recruited. Peripheral blood was drawn from all participants to analyze the BDNF exon IX promoter methylation levels as well as serum BDNF protein and mRNA levels, at baseline and after four weeks of antidepressant treatment. Methylation sequential analysis showed that patients with MDD (n = 39) had a higher methylation level at CpG site 217 and lower methylation levels at CpG site 327 and CpG site 362. Drug responders (n = 25) had a higher methylation level at CpG site 24 and CpG site 324 than the non-responders (n = 11). Patients with MDD had a lower serum BDNF protein and mRNA levels than the healthy controls. In conclusion, these results showed that BDNF exon IX promoter methylation levels, serum BDNF protein level, and serum BDNF mRNA level could contribute to the pathophysiology of a major depressive disorder.
Low-Dose Propranolol as Secondary Prophylaxis for Varix Bleeding Decreases Mortality and Rebleeding Rate in Patients with Tense Ascites
Authors: Park Jin Hwa , Jun Dae Won , Choi Jun , Koh Dong Hee , Yoon Jai Hoon , Lee Kang Nyeong , Lee Hang Lak , Lee Oh Young , Yoon Byung Chul , Choi Ho Soon
Published: April 2019

Background and Aim: The risk and benefit of non-selective propranolol in patients with tense ascites are controversial. This study aimed to investigate the effect of propranolol as secondary prophylaxis on varix rebleeding and overall mortality in patients with tense ascites. Methods: This study used a database of the Health Insurance Review and Assessment Service (HIRAS), which provides health insurance to 97.2% of the total population in Korea. A total of 80,071 patients first variceal bleeding as the first decompensated complication enrolled from 2007 to 2014. Results: There were 2274 patients with large-volume ascites prescribed propranolol as secondary prophylaxis after first varix bleeding. The average prescription dose of propranolol as secondary prophylaxis was 74 mg/day in patients with large-volume ascites. The mean duration of rebleeding was 22.8 months. Result of analysis showed that low-dose propranolol (40–120 mg/day) compared to inadequate propranolol dose (<40 mg/day) as secondary prophylaxis decreased overall mortality and varix rebleeding in patients with tense ascites. Conclusions: Low-dose propranolol (40–120 mg/day) as secondary prophylaxis for variceal re-bleeding decreased overall mortality and varix rebleeding recurrence in patients with tense ascites.
A JND-Based Pixel-Domain Algorithm and Hardware Architecture for Perceptual Image Coding
Authors: Wang Zhe , Tran Trung-Hieu , Muthappa Ponnanna Kelettira , Simon Sven
Published: April 2019

This paper presents a hardware efficient pixel-domain just-noticeable difference (JND) model and its hardware architecture implemented on an FPGA. This JND model architecture is further proposed to be part of a low complexity pixel-domain perceptual image coding architecture, which is based on downsampling and predictive coding. The downsampling is performed adaptively on the input image based on regions-of-interest (ROIs) identified by measuring the downsampling distortions against the visibility thresholds given by the JND model. The coding error at any pixel location can be guaranteed to be within the corresponding JND threshold in order to obtain excellent visual quality. Experimental results show the improved accuracy of the proposed JND model in estimating visual redundancies compared with classic JND models published earlier. Compression experiments demonstrate improved rate-distortion performance and visual quality over JPEG-LS as well as reduced compressed bit rates compared with other standard codecs such as JPEG 2000 at the same peak signal-to-perceptible-noise ratio (PSPNR). FPGA synthesis results targeting a mid-range device show very moderate hardware resource requirements and over 100 Megapixel/s throughput of both the JND model and the perceptual encoder.
Can Traditional Authority Improve the Governance of Forestland and Sustainability? Case Study from the Congo (DRC)
Authors: Majambu Eliezer , Mampeta Wabasa Salomon , Welepele Elatre Camille , Boutinot Laurence , Ongolo Symphorien
Published: April 2019

With about 107 million hectares of moist forest, the Democratic Republic of Congo (DRC) is a perfect paradox of a natural resources endowed country caught in repeated economic and socio-political crises. Democratic Republic of Congo possesses about 60% of the Congo basin’s forest on which the majority of its people rely for their survival. Even if the national forest land in the countryside is mainly exploited by local populations based on customary rights, they usually do not have land titles due to the fact that the state claims an exclusive ownership of all forest lands in the Congo basin including in DRC. The tragedy of “bad governance” of natural resources is often highlighted in the literature as one of the major drivers of poverty and conflicts in DRC. In the forest domain, several studies have demonstrated that state bureaucracies cannot convincingly improve the governance of forestland because of cronyism, institutional weaknesses, corruption and other vested interests that govern forest and land tenure systems in the country. There are however very few rigorous studies on the role of traditional leaders or chiefdoms in the governance of forests and land issues in the Congo basin. This research aimed at addressing this lack of knowledge by providing empirical evidence through the case study of Yawalo village, located around the Yangambi Biosphere Reserve in the Democratic Republic of Congo. From a methodological perspective, it used a mixed approach combining both qualitative (field observations, participatory mapping, interviews, focal group discussions, and desk research,) and quantitative (remote sensing and statistics) methods. The main findings of our research reveal that: (i) vested interests of traditional rulers in the DRC countryside are not always compatible with a sustainable management of forestland; and (ii) influential users of forestland resources at the local level take advantage of traditional leaders’ weaknesses—lack of autonomy and coercive means, erratic recognition of customary rights, and poor legitimacy—to impose illegal hunting and uncontrolled forest exploitation.
Numerical Assessment on Rotation Effect of the Stagnation Surface on Nanoparticle Deposition in Flame Synthesis
Authors: Hu Lilin , Miao Zhu , Zhang Yang , Zhang Hai , Yang Hairui
Published: April 2019

The effect of rotation of the stagnation surface on the nanoparticle deposition in the flame stabilizing on a rotating surface (FSRS) configuration was numerically assessed using CFD method. The deposition properties including particle trajectories, deposition time, temperature and surrounding O2 concentration between the flame and stagnation surface were examined. The results revealed that although flame position is insensitive to the surface rotation, the temperature and velocity fields are remarkably affected, and the deposition properties become asymmetric along the burner centerline when the surface rotates at a fast speed (rotational speed ω ≥ 300 rpm). Particles moving on the windward side have similar deposition properties when the surface rotates slowly, but the off-center particles on the leeward side have remarkable longer deposition time, lower deposition temperature, and lower surrounding O2 concentration, and they even never deposit on the surface when the surface rotates at a high speed. The rotation effect of the stagnation surface can be quantitatively described by an analogous Karlovitz number (Ka’), which is defined as the ratio of characteristic residence time of moving surface to the aerodynamics time induced by flame stretch. For high quality semiconducting metal oxide (SMO) films, it is suggested that Ka’ ≥ 1 should be kept.
Optimal Design of Isothermal Sloshing Vessels by Entropy Generation Minimization Method
Authors: Jamalabadi Mohammad Yaghoub Abdollahzadeh
Published: April 2019

In this manuscript, the optimal design of geometry for a forced sloshing in a rigid container based on the entropy generation minimization (EGM) method is presented. The geometry of the vessel considered here is two dimensional rectangular. Incompressible inviscid fluid undergoes horizontal harmonic motion by interaction with a rigid tank. The analytical solution of a fluid stream function is obtained and benchmarked by Finite element results. A parameter study of the aspect ratio, amplitude, and frequency of the horizontal harmonic motion is performed. As well, an analytical solution for the total entropy generation in the volume is presented and discussed. The total entropy generation is compared with the results of the Reynolds-Averaged Navier–Stokes (RANS) solver and the Volume-of-Fluid (VOF) method). Then, the effect of parameters is studied on the total entropy generated by sway motion. Finally, the results show that, based on the excitation frequency, an optimal design of the tank could be found.
Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products
Authors: Subramani Ramesh , Sipkema Detmer
Published: April 2019

Rare actinomycetes are prolific in the marine environment; however, knowledge about their diversity, distribution and biochemistry is limited. Marine rare actinomycetes represent a rather untapped source of chemically diverse secondary metabolites and novel bioactive compounds. In this review, we aim to summarize the present knowledge on the isolation, diversity, distribution and natural product discovery of marine rare actinomycetes reported from mid-2013 to 2017. A total of 97 new species, representing 9 novel genera and belonging to 27 families of marine rare actinomycetes have been reported, with the highest numbers of novel isolates from the families Pseudonocardiaceae, Demequinaceae, Micromonosporaceae and Nocardioidaceae. Additionally, this study reviewed 167 new bioactive compounds produced by 58 different rare actinomycete species representing 24 genera. Most of the compounds produced by the marine rare actinomycetes present antibacterial, antifungal, antiparasitic, anticancer or antimalarial activities. The highest numbers of natural products were derived from the genera Nocardiopsis, Micromonospora, Salinispora and Pseudonocardia. Members of the genus Micromonospora were revealed to be the richest source of chemically diverse and unique bioactive natural products.
Research on Fatigue Strength for Weld Structure Details of Deck with U-rib and Diaphragm in Orthotropic Steel Bridge Deck
Authors: Chen Yixin , Lv Pengmin , Li Datao
Published: April 2019

The orthotropic steel bridge deck weld structure would easily cause fatigue cracking under the repeated action of vehicle load. This paper took the steel box girder in a bridge as a research object, researched the mechanical properties of the steel plate and the microstructure of the welded joint, then designed the fatigue specimens of the deck plate and did the fatigue test. The Δσ-N curves and stress amplitudes of the weld details of the deck plate with U-rib and diaphragm under different probabilities of survival were obtained. After extended the Δσ-N curves to the long life range, the fatigue damage calculation equation of the detail was proposed, and the cut-off limit under the 50% and 97.7% probability of survival were 81.50 MPa and 53.11 MPa, respectively. Based on the actual vehicle load spectrum and simplified finite element model of the steel box girder section, the stress amplitude of the details of the weld joint was calculated. The calculation result shows that the maximum stress amplitude of the concerned point was 38.29 MPa, less than the cut-off limit. It means that the fatigue strength of the details of the weld joint meet the requirement of the fatigue design.
Effect of Si Content on the Corrosion Behavior of 420 MPa Weathering Steel
Authors: Sun Rui , Yu Qiang , Zhang Yue , Yan Xuqiang , Lu Yuchen , Zhang Chunling , Wang Qingfeng
Published: April 2019

The effect of Si content (0.12%, 0.34%, and 0.48%) on the corrosion behavior of weathering steel in a simulated marine environment was investigated in a dry/wet alternating cycle corrosion experiment. Corrosion weight gain, X-ray diffraction (XRD), scanning electron microscope (SEM), energy dispersive spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS), and electrochemical methods were used to measure the regularity and nature of the rust. The results show that the corrosion process could be divided into an initial stage where the corrosion rate increased and a later stage where the corrosion rate decreased before remaining stable. The corrosion rate was the lowest for a Si content in the weathering steel of 0.48%. The corrosion products of all three steel groups contains α-FeOOH, β-FeOOH, γ-FeOOH, Fe3O4, and large amounts of amorphous compounds. Furthermore, Si benefits the transformation of β-FeOOH and γ-FeOOH to stable phases. The addition of the Si alloying element is beneficial to the formation of dense and compact rust layers that enhance the electrochemical resistance of weathering steel and silicon oxide influences the self-corrosion potential of the corrosion products.
The Effect of Honing Angle and Roughness Height on the Tribological Performance of CuNiCr Iron Liner
Authors: Ma Siqi , Liu Yuchen , Wang Zichun , Wang Zheng , Huang Ruoxuan , Xu Jiujun
Published: April 2019

This work investigated the effect of honing morphologies of CuNiCr iron liner on its tribological properties sliding against the Cr-Al2O3 coated piston ring. The worn surface morphology and elements distribution as well as the wear behaviors of CuNiCr iron liner were analyzed to explore the influencing of the honing angle and roughness height on the friction and wear resistance. The results show that the optimized honing angle and roughness can improve the tribological performance of the iron liner, and different tribological characteristics are closely related to different roughness parameters. The wear process of the CuNiCr iron liner against Cr-Al2O3 coated piston rings in sequence was platform flattening, plastic flow, growth of the flakes on the platform edge and flakes debonding. For the smooth surface, the plastic deformed flakes were much fewer due to the low height of the platforms, thus the grooves were not fully filled and there was a slight effect of the debonded debris on the friction pair.
Geochronology of Magmatism and Mineralization in the Dongbulage Mo-Polymetallic Deposit, Northeast China: Implications for the Timing of Mineralization and Ore Genesis
Authors: Wang Fengxiang , Li Qiangfeng , Liu Yifei , Jiang Sihong , Chen Chao
Published: April 2019

The recently discovered Dongbulage Mo-polymetallic deposit is located in the southern part of the Great Xing’an Range, northeast China. Mineralization is closely related to the emplacement of Middle–Late Jurassic granitoids. In order to understand the petrogenetic link between mineralization and host granitoids, this study presents new zircon U–Pb ages, bulk-rock geochemistry, and molybdenite Re–Os ages for the Dongbulage deposits. LA-ICP-MS zircon U–Pb dating of the monzogranite and syenogranite intrusions yielded two weighted mean 206Pb/238U ages: of 164 ± 2 Ma and 165 ± 3 Ma, respectively. The subvolcanic rocks (red porphyritic granite and rhyolite) yielded a time interval between 161 ± 2 and 162 ± 3 Ma. In addition, molybdenite from the Dongbulage deposit gave a Re–Os isochron age of 162.6 ± 1.5 Ma, which was interpreted as the age of the mineralization. The new geochronology has established the close temporal and genetic relationships between the mineralization event and the emplacement of the Middle–Late Jurassic granitoids. Bulk-rock geochemistry shows that the Dongbulage granitoids are characterized by high SiO2, K2O, and A/CNK [Al2O3/(CaO + Na2O + K2O)(molar ratio)] values, and low TiO2, CaO, and MgO values, indicating a metaluminous to peraluminous, high-K calc-alkaline affinity. The granitoids also featured enrichments of large ion lithophile elements and light rare earth elements (LREE), and a relative depletion of high field strength elements (HFSE), along with an increasing negative δEu anomaly. The high differentiation index (DI), ranging from 81.75 to 94.76, and obvious fractionation between LREE and HREE, indicate that the Dongbulage granitoids are highly fractionated, metaluminous–peraluminous, and high-K calc-alkaline I-type granites. Combined with the regional geology, the Dongbulage granitoids may have formed during post-orogenic extension that followed the Mongol–Okhotsk Ocean closure coeval with subduction of the paleo-Pacific plate.
Lethality of Sesquiterpenes Reprogramming Red Palm Weevil Detoxification Mechanism for Natural Novel Biopesticide Development
Authors: Hussain Abid , Rizwan-ul-haq Muhammad , AlJabr Ahmed Mohammed , Al-Ayedh Hassan
Published: April 2019

Natural biopesticide development for invasive populations of red palm weevils is mainly responsible for the destruction of date palms and demands an extensive screening program of plant secondary metabolites. In the current study, the pesticidal potential of sesquiterpenes (C15 H24), an important class of plant secondary metabolites primarily composed of three isoprene units, was evaluated by laboratory toxicity, feeding performance bioassays, and host detoxification gene expression patterns. Dose-mortality response bioassays performed against mid-aged eighth-instar red palm weevil larvae revealed dose-dependent mortality. Only three sesquiterpenes, including Farnesol (LD50 = 6559 ppm) and Farnesyl acetate (LD50 = 7867 ppm), are considered to have significant toxicity, with Picrotoxin (LD50 = 317 ppm) being the most toxic. Furthermore, highly toxic sesquiterpene (Picrotoxin) established in the current study tremendously reduced the feeding performance indices, including the efficacy of conversion of digested food (ECD) (81.74%) and the efficacy of conversion of ingested food (ECI) (73.62%). The least toxic sesquiterpenes, including β-Caryophyllene, (+)-Cedrol, Nerolidol, (+)-Nootkatone, and Parthenolide, observed in the current study failed to impart significant reductions of ECI and ECD indices. Lethality of the least toxic sesquiterpenes was overcome by greatly inducing gene expressions of Glutathione S transferase (GST) and Cytochrome P450. These encouraging results enabled us to suggest Picrotoxin as a promising biopesticide for the control of red palm weevil infestations.
Effects of a Novel Nutraceutical Combination (Aquilea Colesterol®) on the Lipid Profile and Inflammatory Biomarkers: A Randomized Control Trial
Authors: Domenech Mònica , Casas Rosa , Ruiz-León Ana Maria , Sobrino Javier , Ros Emilio , Estruch Ramon
Published: April 2019

Background: Cholesterol-lowering nutraceuticals are useful in the management of moderate hypercholesterolemia. Methods: In a parallel-group, randomized, placebo-controlled double-blind trial we evaluated the effects on plasma total cholesterol, low-density lipoprotein cholesterol (LDL-c), and inflammatory biomarkers of a nutraceutical combination (Aquilea Colesterol®) containing phytosterols (1.5 g), red yeast rice providing monacolin K (10 mg), hydroxytyrosol (5 mg), and plasma cholesterol values >5.17 mmol/L (>200 mg/dL) and LDL-c >2.97 mmol/L (>115 mg/dL). At baseline and at one and three months we recorded dietary habits; anthropometric parameters; blood pressure; lipid profile; fasting glucose; liver, renal, and muscle function tests, C-reactive protein (hs-CRP); and interleukin-6. Results: 13 men and 27 women (mean age 61.8 years) completed the trial; 20 participants received the nutraceutical and 20 received placebo. No adverse effects were noted. Compared to placebo, at one and three months the nutraceutical reduced total cholesterol by 11.4% and 14.1%, LDL-c by 19.8% and 19.7%, and apolipoprotein B by 12.4% and 13.5%, respectively (p < 0.001; all). hs-CRP decreased significantly (p = 0.021) in the nutraceutical group. Conclusion: The nutraceutical Aquilea Colesterol® is useful for reducing total cholesterol, LDL-c, and inflammation in individuals with moderate hypercholesterolemia.
Synthesis of Cyano-Substituted Conjugated Polymers for Photovoltaic Applications
Authors: Yang Mun Ho , Jin Ho Cheol , Kim Joo Hyun , Chang Dong Wook
Published: April 2019

Three conjugated polymers, in which the electron-donating (D) 5-alkylthiophene-2-yl-substitued benzodithiophene was linked to three different electron-accepting (A) moieties, i.e., benzothiadiazole (BT), diphenylquinoxaline (DPQ), and dibenzophenazine (DBP) derivative via thiophene bridge, were synthesized using the Stille coupling reaction. In particular, the strong electron-withdrawing cyano (CN) group was incorporated into the A units BT, DPQ, and DBP to afford three D–A type target polymers PB–BTCN, PB–DPQCN, and PB–DBPCN, respectively. Owing to the significant contribution of the CN-substituent, these polymers exhibit not only low-lying energy levels of both the highest occupied molecular orbital and the lowest unoccupied molecular orbital, but also reduced bandgaps. Furthermore, to investigate the photovoltaic properties of polymers, inverted-type devices with the structure of ITO/ZnO/Polymer:PC71BM/MoO3/Ag were fabricated and analyzed. All the polymer solar cells based on the three cyano-substituted conjugated polymers showed high open-circuit voltages (Voc) greater than 0.89 V, and the highest power conversion efficiency of 4.59% was obtained from the device based on PB-BtCN with a Voc of 0.93 V, short-circuit current of 7.36 mA cm−2, and fill factor of 67.1%.
Balancing Multiple Roles of Repositories: Developing a Comprehensive Repository at Carnegie Mellon University
Authors: Scherer David , Valen Daniel
Published: April 2019

Many academic and research institutions today maintain multiple types of institutional repositories operating on different systems and platforms to accommodate the needs and governance of the materials they house. Often, these institutions support multiple repository infrastructures, as these systems and platforms are not able to accommodate the broad range of materials that an institution creates. Announced in 2017, the Carnegie Mellon University (CMU) Libraries implemented a new repository solution and service model. Built upon the Figshare for Institutions platform, the KiltHub repository has taken on the role of a traditional institutional repository and institutional data repository, meeting the disparate needs of its researchers, faculty, and students. This paper will review how the CMU Libraries implemented the KiltHub repository and how the repository services was redeveloped to provide a more encompassing solution for traditional institutional repository materials and research datasets. Additionally, this paper will summarize how the CMU University Libraries surveyed the current repository landscape, decided to implement Figshare for Institutions as a comprehensive institutional repository, revised its previous repository service model to accommodate the influx of new material types, and what needed to be developed for campus engagement. This paper is based upon a presentation of the same title delivered at the 2018 Open Repositories Conference held at Montana State University in Bozeman, Montana.
Measuring and Allocating Systemic Risk
Authors: Brunnermeier Markus K. , Cheridito Patrick
Published: April 2019

In this paper, we develop a framework for measuring, allocating and managing systemic risk. SystRisk, our measure of total systemic risk, captures the a priori cost to society for providing tail-risk insurance to the financial system. Our allocation principle distributes the total systemic risk among individual institutions according to their size-shifted marginal contributions. To describe economic shocks and systemic feedback effects, we propose a reduced form stochastic model that can be calibrated to historical data. We also discuss systemic risk limits, systemic risk charges and a cap and trade system for systemic risk.