bluuebunny/crossref_metadata_2025 huggingface dataset:
La cerámica vidriada de A Pousada (Santiago de Compostela): Un estudio estilístico y arqueométrico
Authors: Prieto Martínez María Pilar , Lantes Suárez Óscar , Alonso Toucido Francisco
Published: October 2018

El yacimiento de A Pousada, excavado en un contexto de arqueología de urgencia, es un despoblado altomedieval, cuyas fases posteriores suministraron un conjunto de materiales cerámicos vidriados adscribibles a época bajomedieval y moderna. En el presente trabajo se muestran los resultados del estudio de una parte de los mismos, centrándose principalmente en el estudio arqueométrico. Las características de sus pastas nos aportan información sobre sus técnicas de factura así como su posible fabricación exógena, datos de vital importancia para comprender el comercio cerámico del momento.
Acute intermittent porphyria with posterior reversible encephalopathy syndrome in pregnancy: a case report
Authors: Arora Hemalata , Baheti Gaurav , Jain Ankur , Bhalsod Maulik , Mehta Varshil
Published: October 2018

Background: The porphyrias are a clique of metabolic disorders caused by a faulty heme-synthesis process. The acute intermittent porphyria (AIP) is the most common type of porphyria. It results from a decrease in the porphobilinogen deaminase enzyme levels (PBG-D) which plays a vital role in the hepatic phase of heme synthesis.
Case Report: A 26-years-old lady without any co-morbidity or prior history of any disease came with acute abdominal pain. The causes of acute abdominal pain such as the ectopic pregnancy and other causes were excluded after investigations. She was eventually diagnosed with AIP and managed accordingly. The findings of MRI Brain were suggestive of posterior reversible encephalopathy syndrome (PRES). The patient was treated with hematin, glucose and symptomatic treatment were also given. However, the patient had persistent autonomic dysfunction and hyponatremia, followed by cardiac arrest and death.
Conclusion: The diagnosis of AIP is often missed in cases of an acute abdominal pain in pregnant women. Early diagnosis of AIP during pregnancy followed by proper management is associated with favourable maternal and foetal outcome. Delay in the management leads to the worse outcomes like maternal morbidity, mortality or foetal loss.
Existence of the first eigenvalue of the eigenvalue problem for the Laplace-Beltrami operator on the unit sphere
Authors: Bodzioch Mariusz , Borsuk Mikhail , Jankowski Sebastian
Published: October 2018

In this paper we formulate and prove that there exists the first positive eigenvalue of the eigenvalue problem with oblique derivative for the Laplace-Beltrami operator on the unit sphere. The firrst eigenvalue plays a major role in studying the asymptotic behaviour of solutions of oblique derivative problems in cone-like domains. Our work is motivated by the fact that the precise solutions decreasing rate near the boundary conical point is dependent on the first eigenvalue.
The pseudo core inverse of a companion matrix
Authors: Gao Yuefeng , Chen Jianlong , Patrício Pedro , Wang Dingguo
Published: October 2018

The notion of core inverse was introduced by Baksalary and Trenkler for a complex matrix of index 1. Recently, the notion of pseudo core inverse extended the notion of core inverse to an element of an arbitrary index in *-rings; meanwhile, it characterized the core-EP inverse introduced by Manjunatha Prasad and Mohana for complex matrices, in terms of three equations. Many works have been done on classical generalized inverses of companion matrices and Toeplitz matrices. In this paper, we discuss existence criteria and formulae of the pseudo core inverse of a companion matrix over a *-ring. A {1,3}-inverse of a Toeplitz matrix plays an important role in that process.
VARIASI GENETIK MADIDIHANG (Thunnus albacares; Bonnaterre, 1788) DENGAN ANALISIS MIKROSATELIT DI PERAIRAN INDONESIA
Authors: Jatmiko Irwan , Rochman Fathur , Agustina Maya
Published: October 2018

Madidihang (Thunnus albacares) merupakan spesies yang bermigrasi jauh yang distribusinya di perairan tropis hingga perairan subtropis. Spesies ini ditemukan di Samudra Atlantik, Hindia dan Pasifik. Informasi genetik ikan dengan migrasi jauh seperti tuna penting diketahui untuk kepentingan pemanfaatan secara lestari. Penelitian ini bertujuan untuk memperoleh informasi keragaman genetik dan struktur populasi yang dieksploitasi dan kekerabatan populasi madidihang di perairan Indonesia. Pengumpulan sampel genetik dilakukan di tiga lokasi yaitu di Barat Sumatra, Selatan Bali dan perairan Sulawesi Utara. Metode yang digunakan adalah analisis mikrosatelit yang terdiri dari ekstraksi, purifikasi, amplifikasi polymerase chain reaction (PCR) dan elektroforesis. Hasil analisis terhadap 3 loci DNA mikrosatelit menunjukkan bahwa tingkat kekerabatan ketiga kelompok sampel relatif dekat yaitu berkisar antara 0,132-0,206. Hal ini menunjukkan bahwa Populasi madidihang di perairan Indonesia merupakan stok tunggal dan terjadi perkawinan acak. Meskipun demikian, sebagai spesies yang bermigrasi jauh lintas negara, pengelolaan madidihang juga memerlukan kerjasama yang baik antar negara yang tergabung dalam organisasi pengelolaan perikanan tuna regional.Yellowfin tuna (Thunnus albacares) is a highly migratory species that distribute from tropical to subtropical waters. This species can be found in the Atlantic, Indian and Pacific Oceans. Genetic information in fish with long distance migration such as tuna is very important for sustainable use. This study aims to obtain information on genetic diversity and population structure exploited and kinship of yellowfin tuna populations in Indonesian waters. Genetic sampling of yellowfin tuna was conducted in three locations in Indonesian waters in western Sumatra, southern Bali and North Sulawesi waters. The methods used was microsatellite analysis which consist of extraction, purification, polymerase chain reaction (PCR) amplification and electrophoresis. The result of 3 microsatellite DNA locus analysis showed that the level of kinship between the three sample groups in Indonesian waters was relatively close, ranging from 0.132 to 0.206. This shows that yellowfin tuna population in Indonesian waters is a single stock and random copulation. However, as a highly migratory species that migrate across the nations, yellowfin tuna management also requires good cooperation among countries incorporated in regional tuna fisheries management organizations.
POLA SEBARAN IKAN PELAGIS DAN KONDISI OSEANOGRAFI DI WILAYAH PENGELOLAAN PERIKANAN NEGARA REPUBLIK INDONESIA 715 (WPP NRI 715) PADA MUSIM PERALIHAN BARAT
Authors: Ma'mun Asep , Priatna Asep , Herlisman Herlisman
Published: October 2018

Nelayan penangkap ikan yang efektif membutuhkan informasi sumberdaya ikan dan pola penyebarannya. Penelitian ini bertujuan untuk mengetahui pola sebaran sumber daya ikan yang dikaitkan dengan kondisi oseanografi WPP-NRI 715. Analisis dilakukan berdasarkan kombinasi metode hidroakustik dan profiling CTD pada stasiun oseanografi yang dirancang secara parallel pada jarak tertentu di lintasan tersebut. Hasil penelitian menunjukkan, estimasi ukuran ikan pelagis yang terdeteksi didominasi oleh ukuran kecil. Ikan pelagis kecil yang terdeteksi didominasi ukuran ikan antara 12-14 cm dan ikan pelagis besar ukuran ikan 28-31 cm. Kepadatan ikan pelagis kecil cenderung menurun dengan rerata faktor 0,4 dengan bertambahnya kedalaman, sebaliknya meningkat dengan rerata faktor 1,7 untuk ikan pelagis besar. Pada saat observasi, dikawasan perairan Laut Maluku bagian timur diindikasikan terjadinya upwelling ditandai dengan suhu rendah, salinitas tinggi, dan klorofil tinggi. Ikan pelagis besar lebih banyak ditemukan pada lokasi yang memiliki karakteristik suhu dan DO yang relatif lebih tinggi sedangkan salinitas lebih rendah dibandingkan dengan lapisan air yang didominasi ikan pelagis kecil. Informasi pola sebaran ikan pelagis ini diharapkan dapat dijadikan rujukan bagi pelaku perikanan tangkap dan masukan untuk bahan perumusan kebijakan pengelolaan perikanan tangkap yang berkelanjutan.Effective commercial fishers need information on fish resources and their distribution pattern. This study aims to determine distribution of fish resources in Indonesian FMA 715 through tracking hydroacoustic method and CTD profiling at stations within regular distances. The results showed that the estimated size of pelagic fish was dominated by small size fish groups. Small pelagic fish were detected at the size ranged between 12-14 cm and large pelagic fish was dominated by the size of 28-31cm. The density of small pelagic fish decreases with depth with average factor of 0.4, while the large pelagic fish with average factor of 1.7.  An indicated upwelling incidence was likely occurred in the eastern part of Mollucas sea region, which were characterized by the low temperature, high salinity and high chlorophyll concentrations. Large pelagic fish were more occasionally found in locations with relatively higher temperature, DO characteristics and lower salinity compared with small pelagic fish. Information on the distribution pattern of pelagic fish is expected to be used as a reference for capture fishermen and inputs in formulating the policy the sustainable fisheries management.
Roles and International Behaviour: Saudi–Iranian Rivalry in Bahrain’s and Yemen’s Arab Spring
Authors: Cerioli Luíza Gimenez
Published: October 2018

Abstract Middle Eastern geopolitics are dynamic and complex. Ideological and religious matters interplay with domestic and international structures, generating several types of relations. This article aims to analyse the rivalry between Saudi Arabia and Iran, two powerhouses that compete for leadership in the Gulf. The objective is to understand this competition through the lens of Role Theory, focusing on the national role conceptions that both countries project outwards. This theoretical framework presupposes that Iran and Saudi Arabia project self-made images that represent cognitive constructions of what policymakers believe their respective nations stand for. As an example, Iran projects a role of bastion of revolutions, which is firmly set against Saudi Arabia’s anti-instability role. Regional instability periods, such as civil unrests, provide useful study cases for investigating the phenomenon of rivalry. Therefore, this article focuses on the Iranian and Saudi reactions to the events related to the so-called Arab Spring in Bahrain and Yemen, detecting when the rivalry is (somehow) present in their international behaviours. In conclusion, the article adds to a better understanding of Tehran’s and Riyadh’s ideological projection, and of how much of the region’s politics are constrained by the rivalry status.
Design and construction of the new library at China Agricultural University
Authors: Peng Hongtao , Zhang Jiahui , Zhou Zhiyuan , Mendis Priyan , Han Feng , Li Zhengtao , Zhang Du
Published: October 2018

A new, world-class library has been built at China Agricultural University in Beijing, the oldest agricultural higher education institute in China. The new building’s attractive natural stone facades reflect both old and new, from bamboo writing slips to barcodes, while the dramatic internal space is user-friendly, energy-efficient and flexible. During construction, an innovative hybrid diaphragm walling solution was adopted due to the high groundwater level and restricted site. Building information modelling technology was also successfully used throughout design and construction, helping to improve construction quality and safety management.
Preparation and proton conduction in liquid crystals containing sulfonic acid moiety
Authors: Yu Qiannan , Zhao Zhengshun , Tan Shuai
Published: October 2018

A series of novel biphenyl benzoate based liquid crystals (1) containing terminal sulfonic acid moieties have been prepared through the etherification reaction for anhydrous proton conduction. The chemical structures of 1 were characterized by nuclear magnetic resonance, Fourier transform infrared spectroscopy and high-resolution mass spectrometry. Differential scanning calorimetry measurements and polarizing optical microscopic observations indicated that 1 exhibited a thermotropic smectic A phase in a temperature range of 188–226°C. X-ray diffraction measurements suggested that the molecules of 1 in the smectic phase formed bilayer nanostructures, wherein the sulfonic acid moieties were lamellar aggregated within the layers to form two-dimensional pathways for proton conduction. Electrochemical impedance spectroscopy measurements suggested that the lamellar assembly of the sulfonic acid moieties in the smectic phase benefited the anhydrous proton conduction of the sulfonic acid derivatives, and proton conductivities on the order of 10−4 S/cm were achieved. The proton conductivity of 1 in the smectic A phase is higher than that in the crystal state and isotropic liquid state.
Combined Structural and Functional Imaging of the Kidney Reveals Major Axial Differences in Proximal Tubule Endocytosis
Authors: Schuh Claus D. , Polesel Marcello , Platonova Evgenia , Haenni Dominik , Gassama Alkaly , Tokonami Natsuko , Ghazi Susan , Bugarski Milica , Devuyst Olivier , Ziegler Urs , Hall Andrew M.
Published: October 2018

Background

The kidney proximal convoluted tubule (PCT) reabsorbs filtered macromolecules via receptor-mediated endocytosis (RME) or nonspecific fluid phase endocytosis (FPE); endocytosis is also an entry route for disease-causing toxins. PCT cells express the protein ligand receptor megalin and have a highly developed endolysosomal system (ELS). Two PCT segments (S1 and S2) display subtle differences in cellular ultrastructure; whether these translate into differences in endocytotic function has been unknown.

Methods

To investigate potential differences in endocytic function in S1 and S2, we quantified ELS protein expression in mouse kidney PCTs using real-time quantitative polymerase chain reaction and immunostaining. We also used multiphoton microscopy to visualize uptake of fluorescently labeled ligands in both living animals and tissue cleared using a modified CLARITY approach.

Results

Uptake of proteins by RME occurs almost exclusively in S1. In contrast, dextran uptake by FPE takes place in both S1 and S2, suggesting that RME and FPE are discrete processes. Expression of key ELS proteins, but not megalin, showed a bimodal distribution; levels were far higher in S1, where intracellular distribution was also more polarized. Tissue clearing permitted imaging of ligand uptake at single-organelle resolution in large sections of kidney cortex. Analysis of segmented tubules confirmed that, compared with protein uptake, dextran uptake occurred over a much greater length of the PCT, although individual PCTs show marked heterogeneity in solute uptake length and three-dimensional morphology.

Conclusions

Striking axial differences in ligand uptake and ELS function exist along the PCT, independent of megalin expression. These differences have important implications for understanding topographic patterns of kidney diseases and the origins of proteinuria.
HİTİT HUKUKİ METİNLERİNDE ATAERKİLLİK VE ANAERKİLLİK IŞIĞINDA VERASET
Authors: KUMAŞ Arif
Published: October 2018

Anadolu’nun
ilk merkezi siyasi devletini kuran Hititler, askerî, siyasi, ekonomik ve sosyal
alanlarda olduğu gibi hukuk alanında da özenli bir kurumsallaşmaya gitmiş,
“Eski Devlet” zamanından itibaren muhtelif konularda kanun hükümleri hazırlayıp
kayıt altına almıştır. Bunlar, devletin işleyişiyle ilgili ferman, vasiyetname,
talimatname ve 200 maddeden oluşan ve tarım, üretim, ceza hukuku ve aile hukuku
gibi birçok alanda hükümler içeren Hitit kanunudur. Kanun niteliğindeki
hükümlerde aile hukuku, evlenme, boşanma, içgüveyilik, evlatlık alma gibi
konuların yanı sıra veraset hususunda da bilgiler bulunmaktadır. Hitit hukuki
metinlerinde veraset meselesi ataerkil aile yapısı temelinde ortaya çıkmıştır. Nitekim I. Hattušili, Hitit tahtı için kız kardeşi
Haštayar’ın oğlu Huzziya’yı veliahtlıktan azledip yerine I. Muršili’yi veliaht
tayin ettiğini vasiyet etmiştir. Telipinu Fermanı’nda kraliyet ailesinin
veraset sırası düzenlenirken kralın hiç oğlu yoksa en büyük kızının kocasının
kral yapılması ve Hitit kanununun bazı maddelerinde erkekler kadınlardan daha
önceliklidir. Bütün bunlar Hititlerde ataerkil toplum yapısının bir
neticesidir. Bunun yanında kadınların da “iwaru” denilen çeyizleri
vardır ki evlenen kadının yanında kocasının evine götürdüğü bu çeyiz, kadın öldüğünde
ardında bırakabileceği mirası, boşanma durumunda ise yanında babasının evine
getirebileceği mal varlığıdır. Hitit kanunlarında kadınların erkeklere göre
bazı ayrıcalıklarının olması, Hititlerde anaerkil bir aile yapısının bulunduğu
görüşünü ortaya çıkarmaktadır. Ayrıca bu durum M.Ö. III. Binyılda Anadolu’da
var olan yerli anaerkil aile yapısından kalma izler olarak da görülmektedir.
THE ASSESSMENT OF THE SCOPE OF IMPLEMENTATION OF THE IDEA OF MULTIFUNCTIONAL RURAL DEVELOPMENT IN LAND CONSOLIDATION PROJECTS IN POLAND
Authors: Sobolewska-Mikulska Katarzyna , Stańczuk-Gałwiaczek Małgorzata
Published: October 2018

Land consolidation is considered as a tool for accomplishingthe goals of multifunctional rural development.However, the mechanisms of execution of the idea do not offera clear explanation. The aim of this paper is to assess thescope of implementation of the idea of multifunctional ruraldevelopment in land consolidation projects in Poland. Thispaper attempts to assess whether all elements of the conceptincluded in land consolidation procedures are dealt with ina sufficient manner. The analyses were based on the exampleof 15 selected land consolidation projects carried out indisparate regions of Poland. This paper presents the analysesof design solutions concerning three major aspects: the improvementof efficiency of farming, the preservation of theenvironment and the landscape, the social influence of landconsolidation. According to the results of the studies, for allanalyzed objects, satisfactory economic results were obtainedwhich indirectly influence the social effects. However, environmentaland landscape solutions were only partially considered.The studies have shown, that in Poland it seems necessaryto create appropriate organizational and administrativestructures in order to generate a tool for implementation of themultifunctional rural development idea within the process ofland consolidation.
MANAGEMENT OF FOOD ALLERGENS IN THE FOOD INDUSTRY
Authors: Pachołek Bogdan , Sady Sylwia , Kupińska-Adamczyk Emilia
Published: October 2018

Ensuring food safety for people suffering fromvarious intolerances faces serious threats posed by allergenswhich have become a challenge for food manufacturers andmass caterers. These businesses are required to developand implement appropriate programs to manage allergenspresent in their sites. The purpose of this paper was to analyzethe actions taken by food manufacturers with respect tosubstances and products causing allergies or food intolerancesin the context of providing consumers with a safe, properlylabeled product. To achieve the objective of this study, a dataanalysis and synthesis method was employed based on requirementsdefined in obligatory and non-obligatory standardsfor food safety assurance and management in the foodproduction sector. In summary, as regards allergen management,the companies must create appropriate conditions andtake adequate measures (including the analysis of risks due tointentional and adventitious presence of allergens in food, andthe implementation of appropriate preventive actions). Solutionsprovided in the mandatory standards, mainly GHP andHACCP, as well as in non-mandatory standards, such as ISO22000, BRC, IFS and SQF, may be helpful in the managementof substances causing allergies or intolerances.
POPULATION SIZE CHANGE IN RURAL AREAS OF WEST POMERANIAN VOIVODESHIP IN 2011–2014
Authors: Ossowska Luiza , Bartkowiak-Bakun Natalia
Published: October 2018

The aim of this study is to discuss changes in thepopulation and indicate the main reasons of these changes inrural areas of West Pomeranian voivodeship. The study wasconducted on the local level and based on Central StatisticalOffice data from the years 2010 to 2014. In the first part ofthe research, main demographic information is discussed. Itincludes population density, natural increase per 1000 populationand net migration per 1000 population in rural areasof West Pomeranian voivodeship. In the next part of the research,the average population growth rate was counted in theyears 2011–2014. Based on these changes, researched unitswere divided into four groups – two groups with positivechanges and two groups with negative changes. Subsequently,the main reasons of the changes in population size were analyzedin particular groups including natural increase, migration,population structure by age, level of unemployment andentrepreneurship. All indicators were designated as averagesfrom 2011 to 2014. According to the results in most of the researchunits, the net migration determined the population size.The net migration was characterized by higher absolute valuesthan natural increase. The population size changes are relatedto density. The lowest density areas are more depopulated.Moreover, the population size changes are positive related tothe level of entrepreneurship and negative related to the levelof unemployment.
POSITIVE AND NEGATIVE EXTERNALITIES OF MANAGEMENT ILLUSTRATED BY THE CASE OF AGRICULTURAL PRODUCTION
Authors: Gołębiewska Barbara , Pajewski Tomasz
Published: October 2018

This study investigates the problems of convergence between objectives of agricultural producers and consumers. It states that nowadays, increasingly often, the farmers’ products have no market price (are not marketed) but are either demanded by the society (positive externalities) or the society is interested in discontinuing their production (negativeexternalities). This study also outlines the key problems that arise from costs and benefits associated with agricultural externalities. The social costs that may be generated by modernagriculture, and the solutions used to restrict the same, were covered by this analysis. The literature on the subject and the Polish FADN databases were used. It was found thatfarms of environmentally friendly producers failed to collect enough payments to compensate for running a green business.
DIFFERENCES IN ENVIRONMENTAL GOVERNANCE LEVELS IN THE SUSTAINABLE DEVELOPMENT OF RURAL AREAS OF THE WIELKOPOLSKIE VOIVODESHIP
Authors: Dolata Małgorzata , Jaworska Magdalena , Jaworska Magdalena
Published: October 2018

The purpose of this paper is to assess the leveland spatial differentiation of selected environmental governanceparameters in the context of implementing the sustainabledevelopment concept in rural areas of the Wielkopolskievoivodeship districts in 2005 and 2015. The research procedurewas made up of three steps: review of the relevant literatureand selection of indicators to describe the environmentalgovernance topics; analyzing the changes in, and spatial differentiationof, specific environmental governance components;and ranking the districts. The basic source of data wasthe online database delivered by the Central Statistical Officein Warsaw, the Local Data Bank. As shown by the results,there is considerable spatial differentiation of specific environmentalgovernance components; however, when analyzedglobally, environmental governance proves to be a relativelynon-diversified process. In 2015, the highest sustainabilitylevels were recorded in rural areas of the following districts:Złotów, Kępno and Jarocin. In turn, the lowest levels werefound in Września, Wągrowiec and Śrem districts.
THE ROLE OF THE COMMON AGRICULTURAL POLICY IN STIMULATING RURAL JOBS IN POLAND
Authors: Nurzyńska Iwona
Published: October 2018

This paper explores the role of the Common AgriculturalPolicy in creating non-agricultural jobs in rural Poland.The analyses were based on monitoring indicators of RuralDevelopment Program 2007–2013 and public statistics. Thepaper argues that dynamic technological changes in agriculturerequire redefining the approach towards challenges relatedto the decreasing demand for human labor in agriculture.Although the CAP proves to have a positive impact on ruraljob creation in Poland, the results are a long way from meetingthe needs. Therefore, this paper calls for a strategic re-orientationof CAP objectives and indicates the need for a moreintegrated policy which offers synergies with other types ofEU and national public aid. Only such a policy mix can enablea more effective creation of quality jobs in rural areas.
MODELING THE NEXUS BETWEEN ENTREPRENEURIAL MARKETING DIMENSIONS AND BUSINESS GROWTH AMONG SMALL AND MEDIUM AGRO-PROCESSING ENTERPRISES IN ZIMBABWE
Authors: Maziriri Eugine Tafadzwa , Mapuranga Miston
Published: October 2018

This study aims to determine the relationship betweenentrepreneurial marketing dimensions and businessgrowth among small and medium agro-processing enterprisesin Zimbabwe. The methodology involved a quantitative approachto collecting and analyzing research data. The fieldstudy was conducted in Bindura, Zimbabwe to collect researchdata from 260 managers of agro-processing SMEs. Usingthe SPSS 24 and AMOS 24 software, the Structural EquationModeling (SEM) procedure was performed to analyze theresearch data. The study’s findings validate the assertion thatdimensions such as product innovation, entrepreneurial orientation,risk-taking and resource leveraging are instrumental instimulating business growth among agro-processing SMEsin Zimbabwe. A robust relationship was also found betweenresource leveraging and business growth. Moreover, managerialimplications of the findings were discussed and limitationsand future research directions were indicated
Run Centrifuge using iMicrobe v1
Authors: J J. Ponsero Alise
Published: October 2018

How to run Centrifuge version 1.0.4-beta (Kim et al. 2016) through the iMicrobe plaform. Centrifugeis a microbial classification engine that enables rapid, accurate, and sensitive taxonomic labeling of metagenomic reads and quantification of species. The system uses an indexing scheme based on the Burrows-Wheeler transform (BWT) and the Ferragina-Manzini (FM) index, optimized specifically for the metagenomic classification problem. More informations about centrifuge can be found here :https://ccb.jhu.edu/software/centrifuge/manual.shtml
DNA size selection (>3-4kb) and purification of DNA using an improved homemade SPRI beads solution. v1
Authors: Frolova Monika
Published: October 2018

Most noncommercial tradition DNA extraction protocols result in a crude DNA preparation. If the DNA is intended to be used for a high-end application like Nanopore sequencing, it requires a thorough clean-up and size selection before it could be used for sequencing. Solid Phase Reversible Immobilisation (SPRI) magnetic beads is a quick and convenient way of purifying and size selecting intact double-stranded DNA from crude DNA. Most commercially available SPRI beads based DNA purification mix is quite expensive so our lab endeavored to develop an inexpensive beads mix which is as good as the commercially available ones. In this effort, our lab has optimized a beads mix for purifying and size selecting crude DNA extracted from eucalyptus and posted on protocol.io,https://www.protocols.io/edit/high-purity-high-molecular-weight-dna-extraction-f-n5ydg7w?step=16. However, this solution was not very effective in purifying crude DNA extracted from fungal material. DNA extracted from fungal material is highly viscous which is indicative of high levels of impurities in the DNA preparation. I tried to improve the beads mix for purifying rust DNA by adding 0.25 % (v/v) Tween-20 into the beads mix. I tested beads mix with Tween-20 to see if adding tween into the solution makes any difference in the recovery, purity and size selection. Turns out that bead solutions with Tween-20 make big difference in the size selection and recovery of the DNA compared to the bead solutions without. I calibrated/tested the bead solution with and without Tween-20 on the 1 kb DNA ladder to establish which DNA solution to beads volume ratio gives optimal recovery and size selection. We found that beads mix with 0.25 % Tween-20 works much better in size selection and recovery than beads mix without Tween-20. The best DNA to beads volume ratios were 1.0: 0.9 and 1.0: 1.0.
Stereotaktik radyocerrahi uygulanan vertebra metastazlarında yanıt değerlendirmesinde PET-BT’nin yeri
Authors: ÖZDEMİR Yurday , TORUN Neşe , TOPKAN Erkan
Published: October 2018

Amaç: Bu çalışmada vertebra metastazlarında stereotaktik radyocerrahi (SRC) sonrası yanıt değerlendirmesinde pozitron emisyon tomografisinin (PET-BT) rolü araştırılmıştır.Gereç ve Yöntem: Geriye dönük olarak 16 veya 18 Gy SRC uygulanmış hastalar incelenmiştir. Analizlere SRC öncesinde herhangi bir derecede vertebra kompresyon kırığı gelişmemiş, radyosensitif olarak bilinen küçük hücreli akciğer ve hematolojik kanserlerli olgular dışındaki tedavi öncesi ve sonrası PET-BT verileri olan hastalar dâhil edilmiştir. Tüm vertebra segmentleri  stabilite açısından spinal instability neoplastic score ’e göre sınıflandırılmış ve yanıt değerlendirmesinde PET Response Criteria in Solid Tumors (PERCIST) kriterleri kullanılmıştır.Bulgular: Toplam 75 hasta 119 VS’e (101 tek, 9 çift) SRC uygulanmış olup büyük kısmını (%66,7) meme kanserli hastalar oluşturmaktadır. VS’lerin %70,6’sı SINS 0-6’ya uymaktadır. Lokal kontrol hastaların %87,4’nde sağlanmış olup 1 yıllık lokal nükssüz sağkalım oranı %92,5 olarak bulunmuştur. İlk yanıt değerlendirme PET-BT’si ortanca 3 ayda (aralık: 1-35 ay) çekilmiş olup sadece 4 (%3.3) VS’de progresyon raporlanırken diğer VS’lerde SRC’ye yanıt mevcuttur (%30.3 tam, %43.7 kısmi, %22.7 stabil). Son PET’de sadece 11 VS’de lokal nüks tespit edilirken ilk PET’de tam yanıt olan hiçbir VS’de nihai olarak lokal nüks gelişmemiştir. İlk PET’de tam yanıt olması son PET’de de yanıt olmasıyla ilişkili bulunmuştur.Sonuç: SRC sonrası yanıt değerlendirmesinde ilk PET-BT yanıtı gerek son kontrol durumunu göstermesi açısından gerekse alternatif tedavileri planlamak açısından değerli bulunmuştur.
A Visão como Ingrediente Principal nas Implementações de Mudanças Planejadas nas Organizações
Authors: Lopes Michelle Da Rosa , Krause Carlos Paulo , Queiroz André Felipe
Published: October 2018

A pesquisa tem como objetivo demonstrar que as implementações de mudanças em uma empresa devem possuir foco na visão organizacional, que precisa ser elaborada por uma coalizão administrativa forte, com credibilidade e poder de penetração na cultura organizacional, além de serem planejadas seguindo critérios e premissas bem definidos. Por meio de pesquisas bibliográficas, procurou-se partir dos conceitos de planejamento, de missão, de liderança e de gerenciamento evidenciar a importância da visão nas implementações de mudanças nas organizações. O trabalho propõe uma estruturação que resume e une os principais conceitos, visando facilitar a compreensão destes pelos gestores. A pesquisa evidenciou a necessidade de o gestor compreender a diferença entre os principais conceitos influentes nas mudanças. Além da importância em buscar compartilhar os valores pessoais aos valores organizacionais, buscando um ponto de equilíbrio visando inovar, manter e aprimorar seus valores, ao longo de sua existência. A visão precisa ser clara e compartilhada entre os colaboradores, pois o conhecimento da visão facilita a aceitação às mudanças empresariais. Os gestores devem se utilizar do emporwerment como fonte geradora de ideias, o que amplia a motivação dos funcionários, as utilizações destas ideias auxiliam a aceitação das mudanças, pois o colaborador passa a sentir que é parte ativa do processo.Palavras-chave: Gerenciamento. Planejamento. Cultura Organizacional. Liderança.AbstractThis research aims to demonstrate that implementations of changes in a company needs a focus on the organizational vision which needs to be elaborated by an administrative platform, with credibility and power of penetration into the organizational culture, besides being planned following well-defined criteria and premises ,through bibliographical research, proposal of concepts of planning, mission, leadership and management, evidencing the importance of vision in the implementation of changes in organizations. The paper proposes a structuring that summarizes and gets together one of the main concepts, aiming to facilitate the understanding of the same by the managers. The research highligthed a need for control, the difference among the key concepts influencing change. In addition to the importance of seeking to share the current values with the organizational values, seeking a point of balance in order to innovate, maintain and improve its values along its existence. The view needs to be accurate and clear shared among employees, because knowledge of the vision facilitates acceptance of business changes. Managers use emporwerment as a source of ideas, which broaden employee motivation, such as the use of change-aiding ideas, and thus the employee feels that he or she is part of the process.Keywords: Management. Planning. Organizational Culture. Leadership.
Memória Organizacional nas Prefeituras da Região Metropolitana de Curitiba
Authors: Bernardino Jean Francisco , Silva Helena De Fátima Nunes
Published: October 2018

O artigo analisa os processos de memória organizacional que auxiliam na gestão pública municipal na Região Metropolitana de Curitiba. A pesquisa tem abordagem qualitativa de natureza aplicada e descritiva. Utiliza para coleta de dados o Grupo Focal, realizado com uma amostra composta por servidores mais antigos, envolvidos com atividades ou projetos estratégicos de seis prefeituras pesquisadas. Utiliza a análise de conteúdo, a partir de categorias preestabelecidas, com apoio do Software Atlas Ti, para análise dos dados da pesquisa. Identifica a similaridade em ações utilizadas, de forma não sistematizada, pelas prefeituras, em alguns processos de memória organizacional como prática de gestão de conhecimento. Os resultados apontam que os processos de memória organizacional, na gestão pública municipal, têm como tendência o registro de informações, mas não há padronização, sistematização e estrutura formal que facilite o compartilhamento para o reuso das informações. Existe falta de continuidade nos trabalhos e comprometimento em efetivar os processos de Memória Organizacional como o registro, a disseminação e o compartilhamento. Conclui que as poucas iniciativas existentes são realizadas, em sua maioria, de forma centralizada ou pessoal, sem o comprometimento em dar continuidade nas atividades e projetos, ou apenas por força legal nos casos que existem leis impondo a ação.Palavras-chave: Gestão do Conhecimento. Memória Organizacional. Gestão Pública Municipal. Compartilhamento e Reuso de InformaçãoAbstractThe article analyzes the organizational memory processes that help in the municipal public management in the Metropolitan Region of Curitiba. The research has a qualitative approach of applied and descriptive nature. It uses for data collection the Focal Group, carried out with a sample composed by older servers involved with activities or strategic projects of six surveyed city halls. It uses the content analysis, from pre-established categories, with the support of Atlas Ti Software, to analyze the research data. It identifies the similarity in actions used, in a non-systematized way, by the city halls, in some organizational memory processes as a practice of knowledge management. The results show that the organizational memory processes in municipal public management tend to record information, but there are no standardization, systematization and formal structure that facilitates sharing for the information reuse. There is a lack of continuity in the work and commitment to make organizational memory processes such as registration, dissemination and sharing. It is concluded that the few existing initiatives are mostly carried out in a centralized or personal way without the commitment to continue activities and projects, or only by legal force in cases where there are laws imposing action.Keywords: Knowledge Management. Organizational Memory. Municipal Public Management. Information Sharing and Reusing
Avaliação por Egressos Como Indicador de Qualidade do Processo de Formação na Graduação
Authors: Meira Maria Dyrce Dias , Oliveira Giselle Silva , Silva Mara Cristina Hototian , Kurcgant Paulina
Published: October 2018

Os graduados representam o produto das Universidades e seu desempenho no mercado de trabalho é um dos parâmetros mais importantes para avaliar a qualidade do ensino. O objetivo desse artigo foi verificar como se deu a formação na graduação, com base na percepção da trajetória profissional trilhada por egressos de um Curso de Enfermagem. Estudo transversal, descritivo desenvolvido em abordagem quantiqualitativa. Participaram 61 egressos graduados entre os anos 2008 a 2012. Aplicou-se questionário semiestruturado utilizando processador on-line “Google Docs”. Realizada a análise descritiva dos dados quantitativos e análise de conteúdo das questões subjetivas. Os participantes eram, predominantemente, jovens e do sexo feminino; 85% haviam realizado pós-graduação; 75% afirmaram satisfação profissional; 90% começaram a trabalhar nos dois primeiros anos, a maioria em hospitais e na Atenção Básica. Da análise temática emergiram três categorias: “A instituição formadora favorece a inserção no mercado de trabalho”; “Estágio curricular supervisionado como diferencial” e “Aspectos para melhorar formação do enfermeiro”. A formação proporcionou capacitação técnico-científica e socioeducativa para o exercício profissional seguro e comprometido com a qualidade do serviço, porém deve haver maior investimento no desenvolvimento de competências ético-políticas.Palavras-chave: Avaliação Educacional. .Educação em Enfermagem. Força de Trabalho.Abstract The graduates represent the universities product and their resourcefulness in the labor market is one of the most important parameters to evaluate the teaching quality. The objective of this study was to verify undergraduate training based on the professional trajectory perception traced by a Nursing Course graduates. The authors carried out a survey study, a descriptive, qualitative and quantitative approach and cross segment, which analyzed data from 61 graduates between the years 2008-2011. Data were collected through semi structured response to a questionnaire sent to graduates by an electronic medium online processor “Google Docs”. Descriptive analysis of quantitative data and content analysis of subjective questions was performed. It is a young population and predominantly female. 85% had completed graduate studies; 75% affirmed professional satisfaction; 90% started working in the first two years, mostly in hospitals and in Primary Health Care. From the thematic analysis three categories emerged: “The training institution favors the insertion in the labor market”; “Supervised curricular internship as a differential” and “Aspects to improve nursing training”. The training provided scientific-technical and educational formation for the safe professional exercise and committed to the service quality, but there must be more investment in the development of ethical-political skills.Keywords: Educational Measurement. Education. Nursing. Labor Force.
O Que é Socioeducação? Uma Proposta de Delimitação Conceitual
Authors: Cunha Eliseu De Oliveira , Dazzani Maria Virgínia Machado
Published: October 2018

O termo “socioeducação” vem sendo amplamente utilizado no Brasil já há algumas décadas, especialmente, no terreno das tecnologias de atendimento a adolescentes em conflito com a lei. Todavia, parece não haver muita clareza em relação a que, precisamente, tal termo se refere, ao que se conclui que esse ainda carece de consistência conceitual. Este artigo teórico tem por escopo brindar a comunidade socioeducativa com uma proposta de delimitação conceitual para o termo, partindo do prescrutamento do percurso histórico do qual ele é tributário, bem como da análise crítica de sua utilização na legislação e na literatura. Tal perquirição histórico-legal conduziu à descoberta de que, no início do século XX, a compreensão de que, em seus anos iniciais, o indivíduo é mais suscetível à instrução e à correção adentrou o sistema de justiça juvenil, favorecendo a tese de que os menores infratores deveriam ser, em vez de punidos, reabilitados socialmente, por meio da educação. Desde então, uma intencionalidade corretora de condutas delitivas juvenis, mediante estratégias educativas, tem se alastrado pelo mundo, sob vários rótulos. Entende-se que a socioeducação é a versão brasileira e atualizada desse intento. Ela compreende os processos educativos direcionados aos adolescentes em conflito com a lei visando a não reincidência infracional. O estudo oferece uma contribuição ao desenvolvimento teórico da temática.Palavras-chave: Socioeducação. Definição. Conceituação. Medidas Socioeducativas. Adolescentes em Conflito com a Lei.AbstractThe term “socioeducation” has been widely used in Brazil already for some decades, especially in the area of care technologies for adolescents in conflict with the law. However, it seems that there is not much clarity about what it refers to, thus we conclude that it still lacks conceptual consistency. This theoretical paper aims to provide the socio-educational community with a proposal of conceptual delimitation for the term, starting from the historical route persecution from which it is tributary, as well as the critical analysis of its use in legislation and literature. This historical-legal perquisition led us to the discovery that in the early twentieth century the understanding that in the early years the individual is more susceptible to instruction and correction came in the juvenile justice system, favoring the thesis that minors offenders should be, rather than punished, socially rehabilitated through education.Since then, an intentionality of to correct juvenile criminal behaviors through educational strategies has spread around the world under several labels. We understand that socioeducation is the Brazilian updated version of this attempt. It refers to educational processes directed at adolescents in conflict with the law aiming at non-recurrence of infraction. The study offers a contribution to the topic theoretical development.Keywords: Socioeducation. Definition. Conceptualization. Socioeducative Measures. Adolescents in Conflict with the Law.
Social Progress for Resilient Regions
Authors: Van Ballekom Pim
Published: October 2018

This paper is the base text for the speech of the EIB Vice President Mr.  Pim van Ballekom on the ERSA Congress in Groningen, on August 2017. This text which represents his and the Bank’s views on the topic “Social Progress for Resilient Regions”. Although in his speech he deviated from the prepared speech to react on topics raised by the other speakers, this text and its contents remain valid.
Futbol jako instytucja społeczno-polityczna w wybranych niedemokratycznych reżimach politycznych w Europie. Analiza porównawcza
Authors: Dmowski Seweryn
Published: October 2018

Celem artykułu jest ukazanie społeczno-politycznego fenomenu futbolu oraz jego roli w wybranych niedemokratycznych reżimach politycznych w Europie. Wykorzystując porównawczą analizę neoinstytucjonalną czterech przypadków reżimów o charakterze faszystowskim (nazistowskie Niemcy, faszystowskie Włochy, frankistowska Hiszpania oraz salazarowska Portugalia), wypracowano typologię kategorii analitycznych umożliwiających określenie znaczenia futbolu jako instytucji społeczno-politycznej we wspomnianych reżimach politycznych, na którą składają się wpływ oficjalnej ideologii na zinstytucjonalizowany futbol oraz mechanizm przejmowania nad nim kontroli przez niedemokratyczną władzę państwową. W toku analizy porównawczej wykazano podobieństwa i różnice w upolitycznieniu futbolu w Niemczech, Włoszech, Hiszpanii i Portugalii – zarówno potwierdzające dotychczasowe wyniki studiów porównawczych nad tymi reżimami, jak i ukazujące nowe płaszczyzny zależności pomiędzy nimi. Zagadnienie to nie było do tej pory analizowane w tak szerokiej perspektywie porównawczej – istniejące opracowania ograniczają się raczej do pogłębionej analizy upolitycznienia sportu ogólnie (a nie wyłącznie futbolu) przez wybrane reżimy faszystowskie.
PE and PEG both matter: a simple formula for unifying them
Authors: LEVASSEUR Michel
Published: October 2018

In business valuation reports, multiples computed by dividing the price of a comparable company’s stock by some relevant accounting numbers (a measure of income for example) are frequently used. Two ratios are especially very popular, the PE and PEG ratios. We show through a limited analytical development that generally no one ratio (PE or PEG) captures all the information provided by the accounting data (forecasted earning and expected growth) and it might be more accurate to combine both of them into a single approach. The proposed model is part of the literature of current valuation models based on accounting drivers, such as RIM or AEG models. Its goal is to take into account the effects of short-term growth, as generally forecast by financial analysts. It provides a simple extension to the so-called traditional model DDM and can be used to infer an estimate of the implied cost of capital.
Idiosyncratic volatility and nominal stock prices: evidence from approximate factor structures
Authors: ROGER Patrick , ROGER Tristan , SCHATT Alain
Published: October 2018

Approximate factor structures defined by Chamberlain and Rotschild (1983) allow to test whether a given quantitative firm characteristic (the nominal stock price in this paper) is a determinant of the idiosyncratic volatility of stock returns. Our study of 8,000 U.S stocks over the period 1980-2014 shows that small price stocks exhibit a higher idiosyncratic volatility than large price stocks. This relationship is persistent over time and robust to variations in the number of common factors of the approximate factor structure. Moreover, this small price effect does not hide a small-firm effect because it is still valid when we analyze the tercile of large firms. Our result confirms that small price stocks have lottery-type characteristics and, therefore, it is not in line with the efficient market hypothesis.
Central Bank Independence and Inflation: the Government debt and Inflation Targeting channel
Authors: BLANCHETON Bertrand , MAVEYRAUD Samuel
Published: October 2018

The paper introduces government debt and monetary strategy (Inflation Targeting - IT) into the empirical literature about the relationship between Central Bank Independence (CBI) and inflation. According to Martin’s (2014) model, CBI is not sufficient to maintain price stability in the long run and requires the adoption of IT as a monetary strategy. Using annual data from the period 1998 to 2010 we consider 87 countries (18 considered as developed and 69 as emerging). By using a panel VAR model we explicitly test a possible reciprocal influence between inflation and government debt. At a global level results show an indirect negative effect of Inflation Targeting and CBI on inflation through the government debt channel. A high level of CBI or the choice of IT as a monetary strategy has a significant negative effect on government debt and on inflation.