bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis and Treatment of Chromic and Non-Chromic Acid Water
Authors: Sonde Dr. V. M.
Published: May 2022

Abstract: This work aims to analyse the chemical processes i.e. anodizing and passivation to reduce water usage and then treatment of chromic and non-chromic water and to provide a feasible and economical solution to the company. The work further finds the detailed study of Aluminium & Brass metals which undergoes certain chemical processes such as Anodizing and Passivation simultaneously, which are carried out in their in-house chemical plant. The study finds the conclusion that in both the processes water is excessively used so it found the solution to install hand showers to reduce the consumption of water. Keywords: Anodizing, Passivation, Aluminium, Brass, Nitric acid, Demineralized water (DM water), Chromic, Non-Chromic water.
THE PROJECT-BASED LEARNING FOR GEOMETRY DURING THE COVID-19 PANDEMIC
Authors: Dwi Warih Sitaresmi Pratiwi , Atus Soliha Imro , Nurazizah Siti
Published: May 2022

The changing system in the current learning process at all levels of education due to the coronavirus pandemic. This study aimed to conduct literature review on project-based online learning during the Covid-19 pandemic and the impact on policies toward home learning activities. A project-based online learning system offers many ways to access learning materials for teachers and students. Many online learning platforms and media can be accessed for free. Some of the free platforms that have proven effective for managing online learning include Google Classroom and Edmodo. At least 12 free online learning resource applications can be used during the Covid-19 pandemic, including Rumah Belajar, ICANDO, Meja Kita, Indonesia X, Kelas Pintar, Google for Education, Microsoft Office 365, Quipper, Ruang Guru, Zenius, Sekolahmu, and Cisco Webex. Some obstacles in implementing online learning include limitations of the Internet and unfamiliar knowledge of teachers and students about the application of online learning media. Therefore, more effort is needed to address these issues, starting with individuals, families, educational institutions, providers, and government services.
THE INFLUENCE OF REALISTIC MATHEMATICS EDUCATION ON YEAR 8 STUDENTS' SPATIAL ABILITY OF CUBOIDS AND CUBES
Authors: Nuryami Nuryami , Janan Tuhfatul , Hasanah Nur
Published: May 2022

This study aims to determine the effect of RME on the spatial abilities of Year 8 students concerning cuboids and cubes. Geometry problems often experienced by junior high school students, such as difficulty knowing the difference between cuboids and cubes, difficulties showing elements of cuboids and cubes, and difficulty imagining cuboids and cubes in the case of rotation. The teacher should not underestimate it because it will impact the next level of learning. Besides, spatial abilities are closely related to other mathematical concepts. One alternative is using RME. This research employed the quasi-experimental method, and samples were selected using purposive sampling techniques. The two classes were selected as samples in this study: the experimental and the control classes. Before conducting the main analysis test, the pre-test score students were tested with the t-test. The initial conclusion was that there was no difference in the spatial ability of the experimental class and the control class. The main analytic test in the post-test was done using U-test. The post-test results show that the average score of the experimental class is higher than the control class; RME positively influences students' spatial abilities.
Force Majeure in Aircraft Lease Agreement and Covid-19: Indonesian and English Law Perspectives
Authors: Hasna Hasna
Published: May 2022

The Covid-19 pandemic has resulted in the establishment of flight restrictions throughout the world. Airlines lose their main source of income. In fact, most aircraft operate from leasing schemes making them unable to fulfill their payment obligations under the aircraft lease agreement. Airlines argue that the Covid-19 pandemic is a force majeure event, is beyond its control, and causes the contractual obligations to be unenforceable. This study reveals Indonesian and British law perspectives on force majeure, related to the Covid-19 pandemic, and analyzes such implementation in the aircraft lease agreement. English law was chosen because most aircraft lease agreements are governed by English law, in accordance with the implementation of the autonomy of the parties of international civil law. This study shows that both Indonesian and English laws regulate force majeure events for the affected party to be released from contract obligations if the party is truly unable to carry out obligations due to force majeure. The event of force majeure must also be regulated specifically in the agreement. However, in the aircraft lease agreement, there is a hell or high-water clause that the obligation to pay rent is absolute regardless of any circumstances. Therefore, the legal provisions regarding force majeure do not apply to aircraft lease agreement unless it is mentioned.
A Deleuzian Reading on Hart’s Internal Point of View
Authors: Citrawan Harison
Published: May 2022

Reading H.L.A Hart’s internal point of view or participant’s self-understanding through Deleuzian philosophy suggests an alternate way of grasping Hart’s refutation of John Austin’s command-based theory of law. The study claims two main arguments. First, a Deleuzian investigation of participants’ self-understanding asserts the way to understand not only what law is but also what is about law, or, to be precise, what law can actually do. Therefore, Hart’s participant’s self-understanding is not simply a property of law but instead, it is a concept that uncovers the capacity of Deleuzian ‘desiring-machines’ in law’s plane of immanence. Second, by putting Hart’s concept to the initial proposition of refutation of Austinian mere habit of obedience, we can situate the participants as desiring-machine whose acceptance to rule is essentially a form of communications. That is, like a rhizome, it has no definite root/source. Self-understanding or acceptance does not stem from a particular sovereign power—it somehow reflects Deleuze’s transcendental empiricism.
Strategi pengembangan daya tarik wisata lembah arca sebagai objek wisata pemandian di desa adat tegenan kecamatan rendang kabupaten karangasem
Authors: Candra I Gede Arta Adi
Published: May 2022

Lembah Arca adalah salah satu daya tarik yang terdapat di kawasan Bali Timur. Tepatnya terletak di Desa Adat Tegenan Kecamatan Rendang, Kabupaten Karangasem, Provinsi Bali. Daya Tarik Lembah Arca memiliki potensi yang cukup tinggi, dengan sumber mata air yang melimpah dan terjaga kebersihannya serta lingkungan sekitar yang asri, bersih, sejuk dan aman menjadikan daya tarik Lembah Arca memiliki peluang yang besar untuk dikembangkan menjadi objek wisata pemandian. Namun, terdapat beberapa masalah yang dihadapi dalam pengembangan daya tarik karena kurang maksimalnya pemanfaatan potensi wisata, sistem pengelolaan yang kurang profesional, ketersediaan fasilitas wisata dan lain-lain. Sehingga diperlukan strategi yang tepat untuk diterapkan sehingga mampu meningkatkan pengembangan daya tarik Lembah Arca. Penelitian ini bertujuan untuk mengetahui potensi yang terdapat di daya tarik serta menganalisis strategi pengembangan daya tarik wisata Lembah Arca. Penelitian ini merupakan penelitian kualitatif dengan pendekatan deskriptif. Analisis data menggunakan metode analisis SWOT untuk mengetahui faktor-faktor strategis dari sisi internal dan eksternal yang dimiliki daya tarik serta menganalisis strategi-strategi yang dapat diterapkan. Selain itu digunakan pula metode QSPM untuk menentukan prioritas strategi yang diterapkan dalam upaya pengembangan daya tarik Lembah Arca. Berdasarkan hasil pengumpulan dan analisis data, pengembangan daya tarik Lembah Arca sebagai objek wisata pemandian berada pada tahap strategi tumbuh dan membangun (growth and build strategy). Strategi utama yang dapat diterapkan adalah dengan membuat loket tiket bagi wisatawan, pemasukan dari biaya tiket masuk dapat digunakan untuk meningkatkan pengelolaan destinasi salah satunya untuk penyediaan fasilitas wisata sehingga dapat memberikan kenyamanan bagi wisatawan dan meningkatkan kualitas destinasi.
Rasurando o retrato, reconfigurando os corpos
Authors: Amaral Diego Granja
Published: May 2022

Este artigo aborda a memória visual brasileira a partir da obra dos artistas e pesquisadores Rosana Paulino e Elian Almeida. De forma mais específica, discuto as estratégias adotadas pelos artistas para revisitar a representação dos corpos negros em fabulações críticas que contribuem para reconfigurar os modos de ver a/na cultura brasileira. Sob um ponto de vista conceitual, o artigo discute questões como o papel do arquivo, colonialidade e cultura visual. A partir da noção de rasura no trabalho de Leda Martins, propõe a noção de rasura como um dispositivo teórico para o pensamento sobre a memória visual brasileira. Espera-se assim, contribuir com uma categoria conceitual que permita enxergar as frestas e rasuras da visualidade no Sul Global.
O corpo e o passado insepulto na ficção latino-americana do século XXI
Authors: De Figueiredo Vera Lucia Follain
Published: May 2022

O artigo propõe uma reflexão sobre a configuração da temporalidade em narrativas latino-americanas do século XXI que, de modo direto ou indireto, ficcionalizam acontecimentos coletivos traumáticos. Partimos da hipótese de que, através de uma estética fantasmática, o passado ganha centralidade como dimensão temporal que se impõe ao presente. A permanência do passado no presente é metaforizada, recorrentemente, pela presença dos ausentes, pela apresentação figural dos mortos, dando-se destaque ao destino dos corpos, sejam os corpos torturados ou desaparecidos das vítimas, sejam os corpos degenerados daqueles que se mantiveram do lado da violência estatal. Para desenvolver tal hipótese, serão colocadas em diálogo obras cinematográficas e literárias contemporâneas como, por exemplo, os filmes Aranha, de Andrés Wood, A Chorona, de Jayro Bustamante, e romances, como Corpos intermináveis, de Cláudia Lage, e Degeneração, de Fernando Bonassi.
Poema-pensamento em Roberto Juarroz
Authors: Silva Gustavo de Castro
Published: May 2022

Pretendemos investigar neste artigo o silêncio, a verticalidade e a palavra nos “Fragmentos verticales”, do poeta argentino Roberto Juarroz. A partir da relação entre poesia e pensamento presente em sua obra analisamos sua proximidade com a noção de logos e a compreensão da poesia como “modo de vida” e “modo de ser”, que a aproxima de uma proposta existencial e ética. A partir da leitura dos 496 aforismas presentes em seu último livro Decimocuarta Poesía Vertical (1997) ponderamos o interesse epistemológico do autor pela reflexão, o conhecimento e as ideias. Nossas conclusões apontam para a percepção de que a relação entre poesia e pensamento está presente na quase totalidade dos “Fragmentos Verticais”.
Constelações da barbárie: história e memória na poesia de Paul Celan
Authors: De Freitas Teodoro Jorge Benedito
Published: May 2022

O presente artigo tem como finalidade discutir as representações da história e da memória no corpus selecionado da poesia de Paul Celan enfatizando, sobretudo, a recuperação da experiência da barbárie com vistas a trazer à tona a memória dos mortos que, de modo programático, foi rechaçada pelas correntes responsáveis por escrever a história. Assim, busca-se compreender/apresentar a poética celaniana como uma poesia compromissada em se fundar como um discurso sobre a história e sobre a memória daqueles que foram obscurecidos/esquecidos pela marcha da morte em Auschwitz.
Réplicas: análisis de un caso de radio educativa en educación a distancia en línea
Authors: Arias-Molina Ángelas
Published: May 2022

En el 2020 se produjo y estrenó Réplicas, una película auditiva pensada para personas con discapacidad visual y empleada como recurso educativo para tres asignaturas de la Cátedra de Trabajo Social de la Universidad Estatal a Distancia (UNED), durante el segundo cuatrimestre de ese mismo año. Si bien la UNED cuenta con una larga trayectoria en estrategias de educación y aprendizaje, se carece de análisis actualizados sobre cómo los recursos educativos alternativos, como las ficciones dramatizadas, influyen en el proceso de formación de la comunidad estudiantil. Por lo tanto, se analiza el papel de Réplicas dentro de los modelos de educación a distancia, educación en línea y radio educativa, y su efectividad para representar y transmitir los conocimientos de estas tres asignaturas. Entre los principales hallazgos se encuentran la vivencia experimental de la teoría a través de la ficción y la importancia de productos educativos especializados para cada asignatura.
Relaciones de la universidad ISPMB con las empresas de Benguela, Angola. Compromiso, satisfacción y expectativas
Authors: Cruz-Acosta Roberto , Gómez-Llata Cázares Enrique Gabriel
Published: May 2022

Las universidades tienen el encargo estratégico de transformar su entorno local y regional para estar a tono con las exigencias del mundo moderno y solventar los problemas que enfrenta la sociedad. Este artículo se propone analizar el compromiso del Instituto Superior Politécnico Maravilla Benguela (ISPMB) para mejorar la calidad de los servicios con el fin de satisfacer la demanda de las empresas en Benguela, Angola. Para ello, se aplicó encuestas a las personas involucradas para recabar la información requerida, con un enfoque mixto y alcance exploratorio-descriptivo. Así, se concluye que, en el ISPMB, a pesar de conocer la importancia del vínculo universidad-empresa, aún son deficientes las acciones que realiza para responder a su compromiso con las empresas, por lo que precisa trazar políticas y estrategias para su mejora continua.
Soundwalking in contested space
Authors: Andrew Brown
Published: May 2022

I am an artist researcher undertaking a Ph.D. by Published, Established, and Creative Works at Nottingham Trent University, entitled ‘Soundwalking in Contested Space’.

Soundwalking is an expanding creative discipline with its origins in situationist practices and soundscape studies. Alongside numerous fellow artists and researchers, I am exploring the far-reaching possibilities of the medium. In my thesis, informed by over two decades of leading art walks and composing soundwalks, I interrogate my own soundwalking practice, that I use as a means of investigating contested space. I consider findings from six of my soundwalks composed between 2013 and 2018 and guide the reader through my process and the methods of aleatoric composition, temporal shift, synchrony, and ordeal that, in combination, distinguish my soundwalks.

Alongside writers and theorists such as Tim Edensor, Brandon LaBelle, and Frauke Behrendt, social geographer Doreen Massey provides a firm theoretical foundation through her conception of space as ‘the product of interrelations’ and imaginable as ‘a simultaneity of stories so far’ (Massey, 2005, p. 9). While Massey adopts a generally progressive tone in her articulation of space, in recognition of the human potential that can be realised through spatial encounters, I place emphasis upon its contested nature, as a product of the unequal power relations that arise out of the everyday interactions of human beings.

My contribution to knowledge is both thematic and methodological, through my core concern of human-contested space, the specific combination of methods that I apply within my practice as research, and in the ways these methods encourage deeper appreciation and understanding. My research journey traces a path through contested urban and rural space and exposes the lived realities of human experience when utopian or hubristic visions falter or fail. My findings are directed towards researchers investigating contested space, be it from artistic, social-historical, or environmental perspectives.
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The optimization of waste transportation systems in Genuk District, Semarang City
Authors: Sisti Tiva , Sumiyati Sri , Samadikun Budi Prasetyo
Published: May 2022

Genuk District is a residential development area which has a role as a Semarang City's transportation hubs. It is directly adjacent to Demak Regency and the Java Sea. As of the time of writing, Genuk District has a population of 117,174 people with the total of 130.88 m³ waste transported to the landfill each day and the percentage of waste transportation services in the area is 38.53%. The waste transportation average operational time is 0.2 hours exceeding the amount of working time with the number of 17 trips/day. This planning aims to arrange the waste transportation system in Genuk District by taking into account the traffic congestion in order to get the optimal operational time and costs. Arm roll truck vehicle operating costs in the existing conditions in 2020 was IDR 1,347,411,591.00, while in the optimized condition would be IDR 1,341,405,786.37. Meanwhile, dump truck vehicle operating cost in the existing conditions in 2020 was IDR 302,002,441.00, while in the optimized condition would be IDR 278,453,956.22. The operational time for waste transportation should be started at 06.00-15.00. After optimization, the average remaining working hours becomes 2.68 hours per day with a vehicle's speed of 57.11 km/hour. The planning for waste transportation system optimization will reduce the retribution costs by IDR 900.00 and increase the percentage of waste transportation services to 53%.
Deployment of treated and compressed biogas as a sustainable fuel for ceramic kiln firing
Authors: Abubakar Ezra , Shariff Rahmatu Yunusa , Sadiq Yusuf Otaru
Published: May 2022

Inefficiency, emission of greenhouses gases and the deleterious effects of carbonaceous fuels on both human health and the environment are responsible for the increased in exploration and adoption of eco-friendly and sustainable fuels to various aspects of human development and production processes. This study was aimed at the generation, treatment and compressing of biogas into Liquefied Petroleum Gas Cylinder (LPGC) for deployment to firing ceramic kiln. The methodology involved the anaerobic digestion of cow dung and the treatment of the generated gas using water scrubbing technology. The results of the study showed an increased in methane content from an untreated value of 43.5% to 93.98%, the elimination of CO2, and H2S; reduction in volume of gas used in firing a ceramic kiln to 1030 °C from 22,300 L of untreated biogas to 492 L of treated biogas, as well as the prevention of 108,000 g of methane, 124,00 g of CO2, 74,400 g of CO and 173.6 g of NO2 from venting into the climate system.
Comparative analysis on perspectives of environmental and non-environmental NGOs on solid waste management in Jos metropolis, Nigeria
Authors: Habila Optimist Yohanna
Published: May 2022

This study aimed to make comparative analysis of perspectives of environmental and non-environmental NGOs in Jos Metropolis on key solid waste issues with a view to provide relevant data that would hopefully help in facilitating collaboration between the state and NGOs as well as between NGOs and relevant local and international development partners. Using purposive approach, 115 NGOs in the study area were identified and given the same questionnaire. The study revealed that there are just as many NGOs working in solid waste management (SWM) as there are NGOs that are not (50% each) and there was a link between the NGO categories across all of the parameters considered in the study. It also demonstrated that NGOs' organizational viewpoint on the solid waste issues examined in the study is unaffected by their orientation or primary field of activity, and that registration as a non-environmental NGO is not a disincentive to intervening the area of environment, particularly SWM. It is recommended that the state government adopts an all-encompassing approach or framework that allows for active NGO participation including all relevant stakeholders in the SWM initiatives undertaken by the responsible government agency. Similarly, local and development partners with interest in environmental protection need to assist the NGOs by partnering with them through funding, technical support, and research among other things.
Network analysis of pig movements in Ecuador: strengthening surveillance of classical swine fever
Authors: Acosta Alfredo , Cardenas Nicolas C. , Pisuna Luis , Gavis Jason , Vinueza Rommel Lenin , Vasquez Kleber Stalin , Grisi-Filho Jose , Amaku Marcos , Goncalves Vitor , Ferreira Fernando
Published: May 2022

The analysis of domestic pig movements have became useful in the
understanding of disease spread patterns and epidemiology, which
facilitates the development of more effective animal diseases control
strategies. The aim of this work was to analyse the static and spatial
characteristics of the pig network, to identify its trading communities
and to analyse the contribution of the network to the transmission of
classical swine fever. Pig movement data were extracted from the
national veterinary service database (2017-2019), using social network
analysis and spatial analysis we constructed a network with registered
premises as nodes and their movements as edges, and also a network of
parishes as its nodes aggregating their premises movements as edges. The
annual network metrics showed in average a diameter of 20.33, a number
of neighbours of 2.61, a shortest path length of 4.39 and a clustering
coefficient of 0.38 (small-world structure). The most frequent movements
were to or from markets (57%). Backyard producers made up 89% of the
network premises, and the top 2% of parishes (highest degree)
contributed to 50% of the movements. The highest frequencies of
movements between parishes were in the centre of the country, while the
highest frequency of movements to abattoirs was in the south-west.
Finally, the pattern of CSF disease outbreaks within the Ecuador network
was likely the result of network transmission processes. In conclusion,
our results represent the first exploratory analysis of domestic pig
movements at premise and parish levels. These results could be taken
into account by the surveillance system to improve its procedures and
update the disease control and management policy, allowing the
implementation of targeted or risk-based surveillance.
Clinical features of patients with primary glioblastoma multiforme and detection of the MGMT protein by immunohistochemistry: Case series
Authors: Cortes William , Tobar Lilian Andrea Torres , Nieto Jose Fernando Polo , Ramirez Oscar Eduardo Mendoza , Lopez Carolina , Sierra Jaime Alejandro , Villamizar Licet , González Juan Pablo Castañeda
Published: May 2022

The objective of this retrospective case series is to describe the
clinical features of patients with primary glioblastoma multiforme and
to identify the presence of the MGMT protein in the tissue. Seventeen
patients were selected. Tissue samples were analyzed by the
neuropathologist to confirm GBM diagnosis.
A legitimação da educação infantil como direito de cidadania
Authors: Silva Souza Alisson da , Santos Cruz José Anderson
Published: May 2022

O presente texto, ancorado na perspectiva Histórico-Cultural em Psicologia, tem como objetivo discutir a importância da constituição da Educação Infantil como direito de cidadania. Este estudo justifica-se pela necessidade de refletir sobre o campo das políticas educacionais voltadas para essa etapa da Educação Básica em nosso país. Para compreender a evolução histórica desse avanço, recorremos às principais pesquisas que têm sido realizadas no território brasileiro. Utilizou-se do método de revisão de literatura descrito por Gil (2002) e Hohendorff (2014). Para endossar nossa reflexão, apresentamos também os marcos legais que consubstanciam a Educação Infantil como direito e a situam no âmbito das políticas educacionais. O estudo observou que as legislações já conquistadas representam ganhos importantes para a infância, contudo, precisam garantir o direito à educação de qualidade de todas as crianças e de acordo com suas especificidades.
Aluminum Leaching from Fluid Warmers: Regulatory Deferral to Clinicians' Decision
Authors: Oydanich Marko , Naftalovich Rotem , Discepola Patrick J. , Doran Jim , Chaudhry Faraz A. , Eloy Daniel J.
Published: May 2022

Fluid-warming systems are crucial in surgical and trauma settings because of their key role in preventing or treating hypothermia and enabling proper resuscitation of blood products that are stored cold. Recently, several manufacturers have issued warnings of the possibility of aluminum leaching from their fluid warmers and cautioned about the potential for aluminum toxicity in patients who underwent fluid resuscitation with these devices. Studies suggest that one of the main factors affecting aluminum leaching in this setting is the coating of the aluminum plate itself. Coating, often with a biocompatible material, appears to reduce aluminum leaching by 100- to 200-fold compared with an uncoated plate. Nonetheless, leaching with the coating is still at a level exceeding U.S. regulations. A few aluminum-free warming systems are available on the market, but these are not carried by all providers and some clinicians may be less familiar with their use. Medical device manufacturers will likely design future warming systems with less potential for aluminum blood contact. In the meantime, the risk of inadequate resuscitation, consequent to the proper fluid warmer no longer being available, is contrasted with the risk of potential toxicity. In the situation described here, the regulators deferred the ultimate decision of which fluid warmer to use in a given situation to the risk-benefit decision of the clinician.
Prácticas pedagógicas de la estrategia Aprende en Casa III
Authors: Hernández Arriaga Mario
Published: May 2022

Durante la pandemia de la covid-19, estudiar e investigar el desarrollo de las nuevas modalidades educativas cobró una importancia relevante. Y en esa línea, este trabajo pretendió describir y comprender las prácticas pedagógicas observadas durante la estrategia implementada en México Aprende en Casa III. Para tal efecto, se observaron las clases virtuales de 368 docentes mexicanos de educación primaria, seleccionados al azar, durante marzo, abril, mayo y junio de 2021. Se trató de una investigación mixta que recurrió al apoyo de guiones estructurados. Algunos resultados muestran que 60.32% “Sí/Siempre” coordinó los aprendizajes de los alumnos acorde con la planificación; 80.70% “Sí/Siempre” emprendió acciones de creatividad e innovación; 80.70% brindó retroalimentación oportuna; 92.66% “Sí/siempre” procuró ser una puerta de entrada a los aprendizajes clave tendiendo un puente de comunicación clara. Por consiguiente, se concluye que las cuestiones actitudinales, y no las plataformas utilizadas, importaron más en el quehacer docente, en específico en la retroalimentación de los trabajos realizados y el posible logro de los aprendizajes.
Models of mitochondrial dysfunction with inducible expression of Polg pathogenic mutant variant
Authors: Kubekina MV , Kalinina AA , Korshunova DS , Bruter AV , Silaeva YY
Published: May 2022

Mitochondrial dysfunctions, which underlie many systemic diseases in animals and humans, may arise from accumulation of mutations in the mitochondrial genome. PolG-alpha enzyme encoded by Polg gene is crucial for replication and repair of the mitochondrial genome. The aim of this study was to assess the possible role of Polg mutations in mitochondrial dysfunctions using in vitro and in vivo animal models. The experiments involved transgenic mice with inducible expression of Polg mutant variant; the methods included cell culture, real time PCR assay, fluorescence flow cytometry, and skeletal muscle functional tests. The results indicate that mouse embryonic fibroblasts (MEFs) expressing Polg pathogenic mutant variant have decreased mitochondrial membrane potential and increased expression of mitophagy markers compared with control cultures. Transgenic animals with systemic expression of the pathogenic variant develop mitochondrial dysfunction which significantly affects muscular performance. In addition, systemic expression of mutated Polg in transgenic animals significantly inhibits expression of TCR subunit α and CD3 coreceptor complex subunits δ and ε in total splenocyte populations and significantly affects cellularity of the thymus without altering its CD4/CD8 subpopulation ratio. Thus, inducible expression of mutated Polg in transgenic animals provides a relevant model for studying mitochondrial dysfunction and its treatment in vitro and in vivo.
Osobennosti processov konsolidacii i rekonsolidacii pamyati pri zritel'nyh i sluhovyh narusheniyah v pozhilom vozraste
Authors: Захарова И. А. , Петраш Е. А. , Никишина В. Б. , Разуваева Т. Н. , Шутеева Т. В.
Published: May 2022

Sensornye narusheniya (zritel'nye, sluhovye) ogranichivayut kolichestvo i kachestvo postupayushchej informacii. Pri etom sushchestvennye zatrudneniya vyzyvaet resheniya voprosa o tom, chto vyyavlennoe narushenie pamyati yavlyaetsya sobstvenno narusheniem pamyati ili obuslovleno sensornymi deficitami. V svyazi s poiskom otveta na postavlennyj vopros nami byla sformulirovana cel' issledovaniya. Cel'yu issledovaniya bylo izuchit' processy konsolidacii i rekonsolidacii pamyati u lic pozhilogo vozrasta s sensornymi narusheniyami. V issledovanii uchastvovali pacienty v vozraste 65–75 let (n = 61), razbitye na chetyre gruppy: pacienty s odnostoronnej nejrosensornoj tugouhost'yu (n = 17); pacienty s dvustoronnej nejrosensornoj tugouhost'yu (n = 14); pacienty s narusheniem zreniya (n = 19); pacienty s sochetannym sensornym deficitom (n = 11). V kachestve metodov ispol'zovali metodiki A. R. Luriya «10 slov» i «Zritel'naya pamyat'», a takzhe eksperimental'nuyu proceduru, predlozhennuyu F. Bartlettom. Ustanovleno snizhenie ob"ema kratkovremennoj sluhorechevoj i zritel'no-obraznoj pamyati po vsem gruppam ispytuemyh u pacientov pozhilogo vozrasta s sensornymi narusheniyami. Dostoverno pokazano izmenenie kachestvenno-kolichestvennyh harakteristik processov konsolidacii i rekonsolidacii pamyati pri sensornyh narusheniyah. Dannoe izmenenie obuslovleno snizheniem ob"ema kratkovremennoj pamyati (kak sluhorechevoj, tak i zritel'no-obraznoj). Sdelan vyvod, chto vazhnymi usloviyami povysheniya effektivnosti processov konsolidacii i rekonsolidacii yavlyayutsya neobhodimost' «podstrojki» vnov' postupayushchej informacii k uzhe imeyushchejsya v pamyati (predshestvuyushchem opyte), a takzhe neobhodimost' dozirovannogo snizheniya ob"ema vnov' postupayushchej informacii s cel'yu sohraneniya ee celostnosti na etape konsolidacii.
Mikrogliya i predpolagaemye makrofagi subfornikal'nogo organa: strukturno-funkcional'nye osobennosti
Authors: Гусельникова В. В. , Разенкова В. А. , Суфиева Д. А. , Коржевский Д. Э.
Published: May 2022

Subfornikal'nyj organ yavlyaetsya vazhnym regulyatorom vodno-solevogo obmena i energeticheskogo balansa organizma, uchastvuet v kontrole raboty serdechno-sosudistoj sistemy i immunnoj regulyacii. V sostav subfornikal'nogo organa vhodyat raznye kletochnye populyacii, sredi kotoryh neoharakterizovannymi ostayutsya mikrogliya i makrofagi. Cel'yu raboty bylo izuchit' strukturnye, citohimicheskie i funkcional'nye harakteristiki mikroglii i makrofagov subfornikal'nogo organa golovnogo mozga krysy. Issledovali obrazcy golovnogo mozga polovozrelyh krys-samcov porody Vistar (n = 8). Dlya vyyavleniya mikroglii i makrofagov primenyali poli- i monoklonal'nye antitela protiv kal'cij-svyazyvayushchego belka Iba1 i lizosomnogo belka CD68 i analizirovali preparaty metodami svetovoj i konfokal'noj lazernoj mikroskopii. V ramkah issledovaniya dana kompleksnaya morfologicheskaya harakteristika kletok mikroglii i makrofagov subfornikal'nogo organa. Pokazano, chto bol'shinstvo Iba1soderzhashchih kletok etoj oblasti golovnogo mozga yavlyayutsya mikrogliocitami, a ne makrofagami. Mikrogliya subfornikal'nogo organa nahoditsya v predaktivirovannom sostoyanii, chto mozhet byt' obuslovleno strukturno-funkcional'nymi osobennostyami etogo organa i specificheskimi funkciyami mestnoj mikroglii. Sredi Iba1-soderzhashchih kletok v subfornikal'nom organe vyyavlena osobaya populyaciya subependimnyh mikrogliocitov, otrostki kotoryh pronikayut v polost' tret'ego zheludochka golovnogo mozga. Pomimo mikroglii v subfornikal'nom organe obnaruzheny edinichnye tkanevye makrofagi, dlya kotoryh harakterno vysokoe soderzhaniem CD68, no neznachitel'noe kolichestvo ili otsutstvie Iba1.
Modeli mitohondrial'noj disfunkcii s induciruemoj ekspressiej mutantnogo varianta gena Polg
Authors: Кубекина М. В. , Калинина А. А. , Коршунова Д. С. , Брутер А. В. , Силаева Ю. Ю.
Published: May 2022

Mitohondrial'nye disfunkcii otvetstvenny za razvitie bol'shogo chisla patologij razlichnyh organov i ih sistem u zhivotnyh i cheloveka. Naibolee chasto oni razvivayutsya vsledstvie nakopleniya mutacij v mitohondrial'nom genome. Za replikaciyu i reparaciyu mitohondrial'nogo genoma otvechaet produkt gena Polg ferment PolG-α. Cel'yu dannoj raboty bylo ocenit' vliyanie ekspressii mutantnogo gena Polg na razvitie mitohondrial'nyh narushenij v in vivo- i in vitro-modelyah. Issledovanie provodili na transgennyh zhivotnyh i pervichnyh kul'turah MEF s primeneniem PCR-RV, flyuorescentnogo okrashivaniya na protochnom citofluorimetre, testov na funkcional'noe sostoyanie myshechnoj sistemy. Pokazano, chto v embrional'nyh fibroblastah transgennyh zhivotnyh s induciruemoj ekspressiej mutantnoj formy gena Polg, sozdannyh nami ranee, nablyudayutsya snizhenie mitohondrial'nogo potenciala i uvelichenie urovnya ekspressii markerov mitofagii po sravneniyu s kontrol'nymi embrional'nymi fibroblastami. Krome togo, v kletkah organizma etih zhivotnyh razvivaetsya mitohondrial'naya disfunkciya, privodyashchaya k snizheniyu pokazatelej vynoslivosti zhivotnyh i sily hvata, snizheniyu ekspressii sub"edinic ε i δ kompleksa CD3 i ɑ-cepi T-kletochnogo receptora v total'noj populyacii splenocitov po sravneniyu s zhivotnymi dikogo tipa. Ekspressiya mutantnoj formy gena Polg privodit k snizheniyu kletochnosti timusa transgennyh zhivotnyh, odnako ne menyaet ego subpopulyacionnyj sostav. Takim obrazom, transgennye zhivotnye s induciruemoj ekspressiej mutantnoj formy Polg mogut sluzhit' relevantnoj model'yu dlya izucheniya processa razvitiya mitohondrial'noj disfunkcii i razrabotki terapevticheskih podhodov in vitro i in vivo.
Zastarelyj zadnij perelomovyvih plecha
Authors: Егиазарян К. А. , Ершов Д. С. , Бадриев Д. А. , Сошников Д. Ю.
Published: May 2022

Zadnie perelomovyvihi neredko yavlyayutsya nediagnostirovannym povrezhdeniem pri pervichnom obrashchenii za medicinskoj pomoshch'yu. Golovka plechevoj kosti vo vremya vyviha zahodit za glenoid, na nej obrazuetsya zona impressii, za schet kotoroj ona i «fiksiruetsya». Na rentgenogrammah v standartnoj pryamoj proekcii prakticheski nevozmozhno zapodozrit' dannoe povrezhdenie. V sluchae dlitel'nogo nahozhdeniya plechevoj kosti v fiksirovannom zadnem vyvihe, impressionnoe povrezhdenie golovki plechevoj kosti bystro progressiruet, i mozhet dostigat' 50% ploshchadi sustavnoj poverhnosti. Associirovannye s dannoj travmoj povrezhdenie sustavnoj guby lopatki, razryv myshc rotatornoj manzhety, poyavlenie nestabil'nosti plechevogo sustava posle ustraneniya vyviha, vyrazhennyj bolevoj sindrom trebuyut ser'eznogo podhoda k lecheniyu dannoj patologii. V predstavlennom klinicheskom sluchae u pacienta krome zadnego vyviha byl srastayushchijsya so smeshcheniem perelom anatomicheskoj shejki plechevoj kosti. CHtoby izbezhat' subakromial'nogo impindzhmenta vmesto ispravleniya polozheniya golovki my otkazalis' ot repozicii i proizveli osteotomiyu s peremeshcheniem bol'shogo bugorka plechevoj kosti distal'no.
Evaluation of the Entrepreneurial and Innovative Universities in Turkey through MultipleCriteria Decision Making Methods
Authors: OĞUZ Suzan
Published: May 2022

Purpose: The purpose of this study is to examine the 2018 performances of the top 10 Entrepreneurial and Innovative Turkishuniversities through Multiple-Criteria Decision Making (MCDM) methods and to rank them.Design/Methodology/Approach: While determining the criteria discussed within the scope of the analysis, TUBITAK'sEntrepreneurial and Innovative University Index criteria were taken into consideration. This Index was created in order toobtain a success ranking based on the indicators determined among universities. In this context, first of all, objective weightvalues of the criteria were calculated by Entropy method. Then, the ranking was made among universities by using Edas andTopsis methods, which are among the MCDM methods.Findings: Analyses performed through all two methods demonstrate that the Middle East Technical University ranks first.When the results of the analysis are evaluated in general, it is seen that the findings are consistent with the results ofTUBITAK.Highlights: Along with globalization, changes and developments taking place in information and communication technologiesworldwide affect universities. Universities should support scientific studies, put emphasis on R&D activities, universityindustry cooperation and patent studies in order to rise in performance rankings.
Analysis on the Reflective Thinking Skills of the 7th and 8th Grade Students toward Problem Solving
Authors: KİLİT Büşra , GÜNER Pınar
Published: May 2022

This study aims to analyze the reflective thinking skills of the 7th and 8th grade students toward problem solving. Using bothqualitative and quantitative data collection tools, this study draws on the mixed-methods design. The sample consists of a totalof 167 students, including 78 female and 89 male students studying in a middle school in the district of Fatih, province ofIstanbul, Turkey in the 2019-2020 academic year. To that end, this study benefits from “The Reflective Thinking Ability Scaletowards Problem Solving” and a personal information form to gather quantitative data. Qualitative data are obtained throughreflective dialogue forms that present the semi-structured interview questions. The analysis of the quantitative data isperformed through descriptive statistics methods, independent samples t-test, correlation analysis whereas the analysis of thequalitative data is conducted through descriptive analysis. The analyses performed in this study ascertain that the reflectivethinking ability of the students toward problem solving is high. This study also concludes that there is a significant correlationbetween this ability and mathematics achievement whilst there is no such significant correlation across genders and gradelevels. Based on the analysis of the qualitative data, it is notable that the reflections of the students are lacking and inadequatein each sub-dimension of reflective thinking, namely, questioning, reasoning and evaluation sub-dimensions, as well as in thisability in general.
Views of Teacher Candidates on Distance Education in the COVID-19 Pandemic Process
Authors: TATLI Zeynep , ER NAS Sibel , ŞEYHOĞLU Ayşegül
Published: May 2022

Purpose: The purpose of this study is to determine the reflection of the faculty of education science and social studiesteacher candidates in the emergency distance education process (their motivation for education, educational activities,purposes and preferences of social media use) during the COVID-19 pandemic process.Design/Methodology/Approach: This research is a qualitatively prepared study. As a research design, it is a descriptiveresearch that is also included in qualitative studies. The research group of this study total consists of 120 science (N = 42; 38females, 4 males) and social studies (N = 78; 60 females, 18 males) teachers candidates. An open-ended survey was used as adata collection tool in the study. The data collection tool was applied within the scope of the "Instructional Technologies"course, which is common in the program of the students of both departments. The data obtained from the survey weresubjected to content analysis.Findings: As a result of the study, it was concluded that the social media environment most used by science/social studiesteacher candidates during the COVID-19 pandemic process was WhatsApp.Highlights: It has been determined that the COVID-19 epidemic process offers significant opportunities science/social studiesteacher candidates to explore the digital learning world. Considering the positive effects of the digital literacy of candidatesduring the COVID-19 epidemic process, it is recommended that teachers, teacher candidates, curriculums and textbooks aredeveloped in terms of digital competencies.
The Relationship Between Preschool Teachers’ Computer And Internet Use and Online Learning Motivation
Authors: KARDEŞ Servet , KAHRAMAN VANGÖLÜ Seren
Published: May 2022

The increasing use of technology in the world and the search for new education methods have made learning processes independent of time and space such as distance education and online learning. Moreover, health concerns have made online learning environments more popular during the pandemic process. Therefore, in this study, the relationship between pre-school teachers' computer and internet use and online learning motivation was examined. For this purpose, the relational scanning model, one of the quantitative research methods, was used in the study. The sample of the study consists of 160 preschool teachers. Computer and Internet Usage Scale and Online Learning Motivation Scales were used to collect data in the study. t-test, one-way variance (ANOVA), Pearson correlation and, simple linear regression analysis was used for data analysis. As a result, it has been revealed that the online learning motivations of preschool teachers do not differ significantly according to gender, time spent on the internet and, the number of media tools used to access the internet. Besides, it has been observed that the online learning motivation of pre-school teachers who have just started the profession is higher than experienced teachers. It was revealed that as the self-efficacy of pre-school teachers using computers and the internet increased, their online learning motivation also increased.
Оцінка рівня залученості до інтернету студентської молоді в період карантинних обмежень, пов’язаних з пандемією COVID-19
Authors: Лепканич А.О., , Миронюк І.С.
Published: May 2022

Метою дослідження є вивчення і оцінка зміни рівня щоденної залученості до інтернету студентської молоді в періоди очного і дистанційного навчання, пов’язаними з карантинними обмеженнями пандемії COVID-19.Матеріали та методи. В ході виконання дослідження було використано загальнонаукові та спеціальні методи: медико-статистичний та метод порівняльного аналізу. Основу дослідження склав соціологічний метод, що передбачав анонімне опитування з використанням оригінальної анкети, сформованої у форматі Googl-форми, студентів денної форми навчання 5 факультетів Ужгородського національного університету та статистична обробка результатів. Результати. У ході виконаного дослідження було виявлено, що під час очного навчання більшість опитаних здобувачів освіти проводили в мережі Інтернет менше 3 годин на добу (58,7% опитаних студентів). Група опитаних, які під час очного навчання перебували в мережі більше 7 годин склала лише 7,8 % респондентів. Під час дистанційного навчання розподіл респондентів за групами суттєво відрізняється. Так, група 1 склала лише 10,3 % опитаних (, що є відображенням переходу значної частки (38,2%) усіх опитаних в групи 2 та 3. При цьому 42,8% опитаних студентів під час дистанційного навчання проводять в мережі Інтернет 7 і більше годин на добу. Висновки. В умовах, що склалися є ризики розвитку інтернет-залежності у даної категорії студентів, особливо зважаючи на тривалі періоди дистанційного навчання в умовах карантинних обмежень. Такі суттєві зміни розподілу часу на різні форми активності протягом доби можуть призводити до формування шкідливих поведінкових моделей, які можуть стати стійкими і після виходу студентської молоді з дистанційного навчання на очне.Ключові слова: інтернет-залежність, студентська молодь, дистанційне навчання.
Digital Texts Support Remote Learning: The Teachers’ and Students’ Perceptions
Authors: Syam Andi Tenrisanna , Rifkiani Anis , Santaria Rustan
Published: May 2022

During the Covid-19 pandemic outbreak, the teachers and their students carried out online distance learning by reading text digitally. This study aims to determine the teachers’ and students’ perceptions towards the use of digital text. The writer applied a quantitative qualitative research design. The participants of this study were six teachers from SMAN 2 Luwu and one teacher from SMK Kristen Seriti; 40 students from SMAN 2 Luwu and SMK Kristen Seriti. The participants were selected by using total sampling technique. The instruments were a questionnaire and a structured open-ended interview. The data were analyzed quantitatively and qualitatively. The results showed that the implementation of digital text was less attractive to students. This was evidenced from questionnaire results which showed that 75% of SMAN 2 Luwu students and 45% of SMK Kristen Seriti students think digital text cannot be understood easily than direct explanations from the teacher. However, students assume that they feel challenged to read the digital text without an immediate answer from the teacher. Moreover, the teachers (50%) agreed that digital text is beneficial in delivering material. This study is hoped to give meaningful information for the teachers, students, and further researcher.
Improving Students' Writing Skills by Using Pictures and Picture Method at Junior High School
Authors: Tarigan Natalia Widya Pasca , Panjaitan Esra Elisabeth , Simbolon Peronika , Damanik Johannes Fikki
Published: May 2022

This study aims to investigate the improvement of students writing skill by using picture and picture method in SMP 21 Simalingkar B. The rational of this study to improve the writing lack on the descriptive text in SMP 21 Simalingkar B. This method of this study was Class Action Research and was carried out in cycle 1&2 in 25 students OF VIII B Medan. The writer collecting data using writing test, documentation, observation and interview. The data was analyzed by using qualitative and descriptive techniques. Based on the recapitulation in the cycle 1 and cycles 2 shown the improvement of students’ writing skill . The percentages in cycle 1 and cycles 2,were 44,8% for pretest, 48,8% for posttest in the cycle 1 and 71,84% for pretest , 81,44% for post test in cycle 2.By on the result of this study, the using of picture and picture method can improve students skills and classroom situation in writing text
The Cultural Effect of Popular Korean Drama: Squid Game
Authors: Siregar Namiratusshofa , Perangin Angin Alemina Br. , Mono Umar
Published: May 2022

AbstractNowadays, the phenomenon of squid game is exploding at an alarming rate. It does not take long for the audience to spread the drama virally, as it is so true to life. People of all ages from all over the world are extremely enthusiastic about the outcome of the drama, which is referred to as euphoria. The descriptive qualitative method was used in this study, and the author discovered that the three most famous trends inspired by the drama are red and green light, dalgona candy, and costume play. Children are more likely to  not consume in order for the rating to be 18+, but the trends can't be denied at all, even when it comes to children. It also has an impact on their mental and behavioral health.