bluuebunny/crossref_metadata_2025 huggingface dataset:
PUSAT KEGIATAN FORUM ANAK TINGKAT PROVINSI DI BANJARBARU BERKONSEP PLAYSCAPE
Authors: Puteri Marina Perdana , Wastuty Prima Widia
Published: April 2024

Forum Anak is a children's organization assisted by the Government of the Republic of Indonesia through the Ministry of Women's Empowerment and Child Protection whose role is to bridge communication and interaction between the government and children throughout Indonesia in the context of fulfilling children's participation rights. In its implementation, Forum Anak South Kalimantan Province needs a facilitiy to hold organizational activities. Currently, the implementation of the South Kalimantan Provincial Children's Forum is facilitated by the secretariat room at the South Kalimantan Province Women's Empowerment and Child Protection Service (DP3A). However, this facility has not been able to optimally accommodate the activities of the South Kalimantan Provincial Children's Forum and has not become a facility that can accommodate activities for the use of leisure time through channeling children's interests and talents. Through the use of the playscape concept and an architectural psychology approach, the design is expected to be able to facilitate Forum Anak activities, increase community contributions in fulfilling children's rights and protection in South Kalimantan Province. , and accommodate complaints and assist children with the role of a forum. children as peer counselors, through public spaces in them which are designed by taking into account the principles of child-friendly space, flexibility and inclusiveness.
KAWASAN WISATA KAMPUNG KETUPAT DI KOTA BANJARMASIN
Authors: Ling Mei , Muchamad Bani Noor
Published: April 2024

Sungai Baru is a settlement of the home industry for ketupat, lontong, and nipah handicrafts which is traversed by the Martapura River, one of the biggest rivers in Banjarmasin City. However, the existence of this home industry has decreased which impacts the economic conditions of the residents. Therefore, Sungai Baru area has the potential to be used as a tourist area that can increase the existence of home industries of ketupat, lontong, and nipah handcrafts to maintain the Banjar culture. The main of the architectural problem for this study is the protrusion of the identity of the ketupat village which can increase the potential of the area. Through the concept of the Eco-Regionalism program with contextual architectural methods, it is hoped that the tourist area can highlight the characteristics of the Sungai Baru area as a ketupat village by paying attention to environmental and community aspects.
TAMAN OLAHRAGA REKREASI DI BANJARBARU
Authors: Rijal Fahrul , Sa'ud Mohammad Ibnu
Published: April 2024

Physical exercise is one of the most important activities to do considering the many benefits that result from exercising, both in terms of the physical and spiritual health aspects of a person. However, due to various factors such as laziness, lack of adequate physical exercise facilities, and the location of each physical exercise facility which is separate from each other, the interest of the Banjarbaru community in physical exercise is low. Banjarbaru Recreational Physical Exercise Park is the answer to this problem. This area is the form of a thematic park that aims to accommodate various types of physical exercise and at the same time as an interactive recreation facility in an integrated area so that people will be able to exercise in a recreational way. In accordance with its objectives, the Banjarbaru Recreational Physical Exercise Park consists of two main functions, namely as a forum that facilitates recreational physical exercise activities and as a recreational facility to attract the interest of the Banjarbaru community to come and exercise. The Superimposition method was chosen as the solution method because it combines and collides two spatial programs in this context in the form of recreational and recreational physical exercise in which each spatial program will be contaminated with each other and form a new pattern so that it will realize the goals to be achieved.
PUSAT KEBUGARAN DENGAN KONSEP ARSITEKTUR BIOFILIK DI KOTA TANJUNG
Authors: Rahma Fitria , Nurfansyah Nurfansyah
Published: April 2024

The design of this fitness center is motivated by everyone's need for a balanced state of mind, body and soul. Through these needs, people are starting to realize that they need to come back and start a holistic lifestyle. The purpose of this design is to provide a place that facilitates wellness-based activities in one place by paying attention to the interaction between space and nature. By utilizing the connection between humans and nature, the wellness center is planned to use the concept of biophilic architecture because it is synonymous with good natural use patterns and the use of design methods by utilizing 5 natural elements as the design method.
PERANCANGAN KANTOR DINAS PEKERJAAN UMUM DAN PENATAAN RUANG KOTA BANJARBARU DENGAN PENERAPAN ARSITEKTUR KOLONIAL MODERN
Authors: Sopha Rizky Naila , Anhar Pakhri
Published: April 2024

The Banjarbaru City Public Works and Spatial Planning Office is one of the official offices located in the Murjani area. This design was carried out because of functional considerations that did not meet the capacity and the Murjani area had a high value in post-independence architecture. The purpose of this design is how to design a representative office according to the needs of its activities and can strengthen the reflection of the Murjani area which has a high value on post-independence architecture. In this design, two methods are used, namely programmatic and historical methods. In this method, the concept of colonial architecture is obtained. This concept is used to reflect the Murjani area which has a high value in colonial architecture. It is hoped that these two methods can produce an appropriate design.
BANJARBARU PERFORMING ART CENTER YANG RESPONSIF DI ERA NEW NORMAL
Authors: Rahayu Silfina , Oktaviana Anna
Published: April 2024

The design of the Performing Art Center in Banjarbaru City was the background of the lack of art container that accommodates and can only facilitate art activists on a small scale. So it can be said that the Banjarbaru City really needs a place that can accommodate art containers creativity, plus the problem in the pandemic era makes the art apparent death. The design of Performing Art Center aim to produce a design concept that can be an art container place responsive to the new normal with new normal concept and the new normal phenomenological approach, as for the appearance of the building applying concept Contemporary Architecture. Concept applied both to the arrangement of mass, circulation, facade, building technology, color and form.
PUSAT KENDALI RUANG PUBLIK DI BANJARBARU
Authors: Rahman Ulya Hafiza , Saud Mohammad Ibnu
Published: April 2024

In the government program the 100 Smart City Indonesia Movement. Banjarbaru City is one of the selected cities from the 100 Smart City Indonesia Movement. Building a Command Center of City is one of the basic steps in the Smart City program, especially applied in public spaces. The problem of the Banjarbaru Command Center is still very lacking in various aspects. The Smart Building concept aims to support the city's Command Center. The application of the Smart People principle in adapting the community is sought to support the path of Banjarbaru towards a Smart City.
PANTI WERDHA DI BANJARBARU
Authors: Ramadini Ratu Lukitasari , Oktaviana Anna
Published: April 2024

Panti Werdha in Banjarbaru is a community service institution managed by the private sector with the aim of promoting the tranquility of the elderly in their old age. The lack of availability of supporting facilities in Banjarbaru has led to a decrease in peer attention to the elderly in Banjarbaru. The hope is that the design of the Nursing Home in Banjarbaru will be able to improve the quality of life for the elderly in Banjarbaru. The problem that the author raises in the design of social services for the elderly is, How is the design of the elderly housing in Banjarbaru that can facilitate comfortable and safe activities for the elderly? The method that the author applies in solving this problem is the Person Centered Map, using the concept of Behavioral Architecture.
BANJARBARU ENGLISH COURSE CENTER
Authors: Pribadi Faiz Baihaqi , Tharziansyah Muhammad
Published: April 2024

English Course Center Banjarbaru aims to make the place a gathering center for activities to introduce or show the importance of speaking English in life for the general public, where there is a lot of potential that requires foreign language skills, especially English. Even so, Banjarbaru as an education city still does not have it, due to the lack of public interest in English. Therefore, the Banjarbaru English Course Center was designed, using the concept of character and the metaphorical method, which is expected to create an English course center that represents the identity of the country of origin and is translated into architectural visuals. The character concept, which takes the English variable and uses a landmark metaphorical approach in England, was chosen because it is able to represent the English Course Center.
PUSAT OLAHRAGA PANAHAN BANJARBARU
Authors: Cahyadi Arif , Sarbini Gusti Novi
Published: April 2024

An Archery sports center is a place to accommodate various types of archery activities with a wider scope. The design focuses on the goal of building facilities to develop the sport. The existence of this goal is based on the problem of the archery room that can threaten the environment. To overcome this, we need a design that is recreational, has educational value and provides a place to compete. By using a programmatic architectural approach, an architect will find it easier to analyze and create a more representative archery design.
PUSAT PEMBINAAN DAN PENGEMBANGAN E-SPORT DI KOTA BANJARBARU
Authors: Munanda Nafta Widayani , Sarbini Gusti Novi
Published: April 2024

Banjarbaru has become a thriving city with various existing communities, from art, food, clothing, conventional sports, and electronic sports, which can invite people from outside the city to come. The electronic sports in Banjarbaru has the potential to be developed as an opportunity to show the local children's potential and have quality players who are no less competitive. Along with the rapid development of E-Sports, and the increasing number of enthusiasts who are highly expected in Banjarbaru, a Guidance and Development are needed to accommodate E-Sport enthusiasts themselves to practice and obtain adequate facilities. The Eco-Futuristic Architecture theme is applied to the design because E-Sport is closely related to technology that has developed until today.
DESAIN FOOD COURT DI KOTA BANJARBARU
Authors: Nafis Muhammad , Sa'ud Mohammad Ibnu
Published: April 2024

Culinary is one of the attractions of the community which has experienced a lot of development to the phenomenon of hanging out culture which is currently a trend in Banjarbaru City. However, due to the absence of a place to accommodate this, a place was created in the form of a Food Court. The design of the Food Court in Banjarbaru City is the answer to this problem with the Third Place Method as a method of solving it which aims as a forum for visitors to carry out certain activities or relax while enjoying culinary delights. The concept applied is Communal Dining Place, which means a space that accommodates social activities and is used for the whole community or community. This concept is based on the actors in this design by considering the settings that are influenced by three elements, namely humans as the subject of actors, activities and human thoughts with different needs.
FASILITAS PENGEMBANGAN UMKM DI BANJARBARU
Authors: Shafly Muhammad Faris , Agusniansyah Nursyarif Agusniansyah
Published: April 2024

MSMEs are one of the employment sectors that have become an important state asset with their potential as a high contributor to the country's GDP. However, in 2020, the contribution of MSMEs has decreased drastically to only 37% of each year which always contributes above 50%. This is due to the COVID-19 pandemic. Therefore it’s necessary for an MSME development facility as an effort to prepare MSME actors in the future in terms of their education and creativity in entrepreneurship to be able to adapt in crisis situations. The approach used is Architectural Programming owned by Donna P. Duerk as a direct response in solving educational, creative, collaborative problems by implementing an exploration of the needs of its development facilities with the facility exploration process using the IP2K strategy as a method assessment parameter, until finally obtaining the concept of programming results. With this facility, it is hoped that MSMEs will become a source of economy that is not easily broken.
TAMAN EDUKASI PANGERAN ANTASARI DENGAN PENDEKATAN NEO-VERNAKULAR KOTA BANJARMASIN
Authors: Mudzakky Abdy Ikhwan , Sarbini Gusti Novi
Published: April 2024

In urban areas, getting information from existing technology is very easy to do. However, it is a little difficult to become dependent for early childhood children who are still not psychologically stable. History is also a part of the information that is easily available at this time. One of the famous historical figures from Banjarmasin is Prince Antasari. Prince Antasari is a National Hero of the kingdom of Banjar in his resistance to the Dutch troops. This makes the history of Prince Antasari need to be known by the people of Banjar itself, especially among children. One way of delivering this information without the need for digital technology is through Educational Parks. The approach that will be applied to the Educational Park is the Neo-Vernacular approach. This approach will find unique things that exist in the Banjar traditional building and apply it to the design of the “Prince Antasari Educational Park with a Neo-Vernacular Approach in Banjarmasin City”.
GEDUNG APRESIASI SENI ANAK BERKEBUTUHAN KHUSUS DI BALIKPAPAN
Authors: Abdillah Nur Fitri , Dahliani Dahliani
Published: April 2024

In the context of art, the perspective of ordinary people sees the work of Children With Special Needs (ABK) only based on compassion. Thus it is felt necessary to plan and design an art appreciation building to appreciate the work of ABK in Balikpapan. The design of this building aims to provide facilities for ABK as a means of artistic expression as well as a place to appreciate artistic talent that is in accordance with the character of ABK. The Experience concept and the Behavioral Architecture method were chosen as a solution to the problem of presenting sensory experiences of space users, especially ABK, whose application includes behavioral consideration.
PENATAAN PEDAGANG KAKI LIMA DI BATU KAJANG KALIMANTAN TIMUR
Authors: Milianti Maya , Octaviana Anna
Published: April 2024

The existence of public open spaces that accommodates people's social activities in Paser Regency, especially in Batu Kajang, is very minimal. The lack of intensity of land for productive open spaces that is economically profitable for street vendors has an impact on the emergence of street vendors that sell along the side of the road in Batu Kajang. The impact of the existence of the street vendor caused the traffic jam. Therefore, to anticipate such conditions, open spaces area that can accommodate the selling activities of street vendors are needed. The method used is architectural programming which is a process of gathering information, analyzing, and making recommendations for the success of the design. In this case, the concept applied to the design area is placemaking which is a form of space through human interaction with buildings and building interactions with the environment.
PERANCANGAN PASAR ANGSAU
Authors: Pamungkas Gaguk Putra , Hartono Rudi
Published: April 2024

Markets are social and infrastructure where businesses buy and sell goods, services, and labor. The existing condition of the site located on Jalan A. Yani, Angsau Village, Pelaihari District, Pelaihari City are as follows: Site Position : Hook/Corner, Site Area: 8,375 m2, Soil Type: Hard Soil, Topography: Flat, Site Orientation: West , Vegetation: Trees, Coconut Trees, Cassava Trees, Bamboo Trees, Weeds, Undergrowth, Weeds, and other plants, Drainage: Artificial, Electrical Networks: Overhead, Site Boundaries: - South: Gas Station - West: Road and Mosque - North: Rifle Company - East: Housing. The position of the site which is near the main road roundabout is a strategic position because it is on a street corner which makes its position open from several directions so that it is very precise and ideal as a business or business area.
PUSAT TERAPI ANAK AUTIS DI MARTAPURA KALIMANTAN SELATAN
Authors: Rahman Erinna Salsabilla Ardafi , Wastuty Prima Widia
Published: April 2024

During the period of cognitive development, some children not a few who experience some problems at the stage of their cognitive development, one of which is the presence of Autism Spectrum Disorder (ASD). It was recorded in January 2018 that there were 500 cases of children with autism in South Kalimantan. In South Kalimantan itself, therapy centers for autistic children are still very few and the facilities they provide are still very limited. And there are still many parents who think therapy for autistic children doesn't make any changes to their children. Meanwhile, in therapy it takes a long time and consistently in therapy and the active cooperation of parents must be active at home. So it is felt that there is a need for an Autistic Children Therapy Center in South Kalimantan at this time. This is realized by the method of Psychological Architecture and the concept of applying the principles of Healing Environment to create an Autistic Child Therapy Center that can improve the behavior of autistic children for the better and provide education to parents.
AKADEMI SEPAKBOLA DENGAN METODE SUPERIMPOSISI DI BANJARBARU
Authors: Rizky Muhammad , Agusniansyah Nursyarif
Published: April 2024

Indonesia South Kalimantan has the potential of a quality football player. With the potential of a good football player, this potential must be developed and directed to be even better. Banjarbaru became a development city after Banjarbaru became the capital of South Kalimantan. The design of the Football Academy using the superimposition method in Banjarbaru aims to have a positive influence on users in creating professional soccer players. This method aims to influence each user's activity for the better. To support the superimposition method, the use of modern architectural concepts is used which aims to influence human behavior driven by design.
PERANCANGAN PASAR BARU MARABAHAN
Authors: Al-Arif Abdurrahman , Mentayani Ira
Published: April 2024

Marabahan City is the capital city of Barito Kuala which is also the center of government and economy, seen from the arrangement of the city between the government and the community's economic center located in the market. Marabahan City also gets the motto of the word Bahalap (beautiful) contrary to the existence of market arrangements and lacking facilities for the community where the source of the economy for most of the people of the Marabahan city are farmers and traders.For the arrangement of the city of Marabahan with the market design for the community with facilities and analysis based on the environmental situation of the city of Marabahan using a behavioral architectural approach with the Behavior setting method. Which combines two aspects, namely between the environment and people's behavior.The result of the design of the new Marabahan market is the existence of stalls for retail traders and the arrangement of stalls and shops and even the layout of the motorcycle parking lot which used to use the main road.
RUMAH KUMPUL LANSIA DI KABUPATEN BANJAR
Authors: Fadli Muhammad , Hartono Rudi
Published: April 2024

An elderly person is someone who is aged 60 years old or above. The Central Bureau of Statistics projects that the number of elderly people will reach one-fifth (19.90%) of Indonesia's total population in 2045. This increase brings problems to the elderly themselves in the form of decreased body function due to the aging process. Rumah Kumpul Lansia is a solution to help the elderly to get professional services and care in their daily lives. The behavioral architecture approach method was chosen to observe the behavior of the elderly to produce a building that suits the character and mindset of the elderly. The result is the concept of "Manoewa" which is able to answer the problems of independence, productivity, health, and insight among elderlies.
SEKOLAH DASAR ALAM DI PEDALAMAN PEGUNUNGAN MERATUS LOKSADO
Authors: Hadariah Hadariah , Andini Dila Nadya
Published: April 2024

Ecological disasters such as landslides and floods caused by natural exploitation in the Meratus Mountains in the form of mining and oil palm plantations should be able to foster a sense of environmental concern for the community to preserve and restore damaged natural conditions. Facilitating children in rural areas with natural schools that introduce the environment to children to develop sensitivity to the environment from an early age. The low number of schools in Loksado Sub-District is also the background to the design of a natural elementary school in the interior of the Loksado Meratus Mountains. This is very important to facilitate the education of rural communities.
PERANCANGAN PALANG MERAH INDONESIA KOTA MUARA TEWEH
Authors: Arsi Ega Nur Muhammad , Nurfansyah Nurfansyah
Published: April 2024

The Indonesian Red Cross, which is often known by the abbreviation PMI, is a national association organization located in Indonesia and engaged in the humanitarian field. The activity that was first carried out by PMI was to help victims of the Indonesian Revolutionary War of Independence and return victims of Allied and Japanese prisoners of war so that the Indonesian Red Cross has gained international recognition. The purpose of the design this time is "How to design the Muara Teweh Indonesian Red Cross (PMI) building which is able to fulfill the activities of the volunteers and their working staff by providing assistance and blood services to the people in the city of Muara Teweh which are appropriate and make rooms with adequate facilities?”. By using the concept of "Local Wisdom" by prioritizing the function of building the PMI building and using the Symbolism Method in the design.
SHOWROOM MOBIL HONDA DENGAN PENERAPAN ARSITEKTUR KONTEMPORER DI KOTA KUALA KAPUAS
Authors: Ramadhan Viki , Nurfansyah Nurfansyah , Febrita Yuswinda
Published: April 2024

The Honda car showroom with the application of contemporary architecture in Kuala Kapuas is a showroom building design that focuses on visual and functional aspects that aim to show the image of Honda products to consumers and meet the needs of car transportation sales facilities in Kuala Kapuas City, especially the Honda brand. This design was motivated by the lack of car transportation sales facilities in Kuala Kapuas and the tips of PT. Honda Trio Raya to continue to provide the best effort in reaching consumers, especially in the Kuala Kapuas area of Central Kalimantan. Contemporary architectural style itself is considered as an architectural style that reflects a quality and novelty, so the concept used to solve this design problem is to apply contemporary architectural principles into the design of the showroom according to the functions and needs of the Honda car showroom itself.
PUSAT PELATIHAN SEPAK TAKRAW BANUA ANAM DI KANDANGAN
Authors: Anwar Muhammad Fuadi , Huzairin Muhammad Deddy
Published: April 2024

Sports is growing every year, including takraw. In South Kalimantan, especially in Banua Anam, sepak takraw is growing. This development needs to be supported by a training center. The Banua Anam Sepak Takraw Training Center has a problem about how to design a sepak takraw training center based on a sepak takraw training program. Programmatic methods are used in design to identify problems so as to produce concepts. The concept of Functional Programming is obtained after going through identification with a programmatic method. These concepts and methods were chosen to produce a functional design based on the athlete's training program and daily activities.
GEDUNG OLAHRAGA PENYANDANG TUNANETRA PADA KAWASAN KOMPLEK PERTUNI BANJARBARU
Authors: Hilpani Muhammad Saidika , Hartono Rudi
Published: April 2024

Sports are very necessary for everyone's sports needs, including the blind. Blind people have limitations in their activities which is a problem in this writing. A special building was created for blind people to exercise in the PERTUNI Banjarbaru complex area using methods that can facilitate independence, comfort and safety when exercising. A design with the concept of orientation and mobility was chosen because this concept can prioritize comfort, comfort and safety for blind people. With this concept, it is hoped to produce a plan that suits the needs of blind people in carrying out sports activities.
The role of neuropeptides (oxytocin, vasopressin, neuropeptide S) in the development of cognitive impairment in Alzheimer’s disease
Authors: Avliyakulyeva A. M. , Kindyakova E. K. , Kuzmina S. V. , Gorina Y. V. , Lopatina O. L.
Published: April 2024

Every year, the number of people diagnosed with Alzheimer’s disease is rapidly increasing. Despite numerous studies, it was not possible to select a therapy that would reliably slow down the course of the disease and result in its complete cure. In this case, any consideration of the issue related to the search for drugs to eliminate cognitive and psychoemotional disorders in Alzheimer’s disease is a pressing problem that deserves special attention.

We collected articles from the PubMed database published over the past 10 years. The aim of this review was to analyze the latest experimental data and results regarding the relationship between Alzheimer’s disease and the activity of neuropeptides, such as oxytocin, vasopressin, and neuropeptide S, and describing the effects that occur upon their administration. This will allow for a more complete understanding of the problem and update information on this issue. The ability of neuropeptides to restore impaired cognitive functions in an animal model of Alzheimer’s disease is examined in more detail.

Detailed information on the relationship and positive effect of the studied neuropeptides on Alzheimer’s disease allows to consider these neuropeptides as potential drugs for the treatment of this disease.
New draft classification of chronic heart failure of the Russian Society of Cardiology: are there any obvious advantages over the current ones?
Authors: Kalyuzhin V. V. , Teplyakov A. T. , Bespalova I. D. , Kalyuzhina E. V. , Chernogoryuk G. E. , Terentyeva N. N. , Grakova E. V. , Kopeva K. V. , Garganeeva N. P. , Livshits I. K. , Ostanko V. L. , Shalovay A. A. , Pushnikova E. Yu. , Aptekar V. D.
Published: April 2024

In the interests of practical healthcare, routine classifications should be modified as rarely as possible. At the same time changes should be discarded only on sufficient grounds, for example, when there are no obvious advantages of a new classification over the existing ones or they can no longer be modified by introducing fundamental changes and amendments. In this regard, the evolution of approaches to the classification of chronic heart failure (CHF) is prominent. It becomes particularly relevant due to the fact that currently experts of the Russian Society of Cardiology (RSC) are actively discussing a new draft classification of CHF. The authors of the lecture gave a brief historical insight and reviewed the main classifications of CHF used in North America, Europe, and Russia. The new classification of CHF proposed by RSC experts, which is actually a modified classification of North American colleagues, does not have obvious advantages over the currently used CHF classification in Russia (since 2002). The latter is based on the classification by Vasilenko – Strazhesko which is familiar to domestic internists, since it has become an indispensable part of their clinical practice and has stood the test of time. In addition, its underlying principles provide the potential for its flexible modification.
Comparative analysis of EEG in patients with schizophrenia receiving various atypical antipsychotics
Authors: Galkin S. A. , Kornetova E. G. , Ivanova S. A.
Published: April 2024

Aim. To conduct a comprehensive analysis of EEG recordings of schizophrenia patients receiving atypical antipsychotics as monotherapy.

Materials and methods. We examined 94 patients with schizophrenia aged 33 [28; 40] years with a disease duration of 10 [4; 15] years. The patients were divided into 5 groups depending on the antipsychotic drugs they took: 1) risperidone – 31 patients; 2) quetiapine – 20 patients; 3) aripiprazole – 11 patients; 4) olanzapine – 13 patients; 5) clozapine – 19 patients. EEG was recorded during wakefulness with closed eyes (background test), 3-minute hyperventilation, and rhythmic photostimulation in all patients. To describe and interpret the received recordings, the EEG classification according to J. Micoulaud – Franchi et al. was used.

Results. EEG modifications (score > 1A) were observed in 61.7% (n = 58) of patients. In the group of patients receiving risperidone, EEG modifications were found in 48.4% of cases, in patients taking quetiapine – in 70% of cases, aripiprazole – in 63.6% of cases, olanzapine – in 61.5% of cases, clozapine – in 73.7% of cases. The frequency of epileptiform patterns in patients receiving olanzapine was significantly higher than in those taking risperidone (p = 0.033) and clozapine (p = 0.032). Slowing in the EEG (score > 1) was more often observed in patients taking clozapine – 63.2% (n = 12), olanzapine – 61.5% (n = 8), and quetiapine – 60% (n = 12). Slower EEG waves were less common in patients receiving aripiprazole – 45.5% (n = 5) and risperidone – 45.2% (n = 14). In the group of patients with EEG slowing (score > 1), the dose of chlorpromazine equivalent was significantly greater compared to patients with normal EEG (p = 0.00046).

Conclusion. The data obtained demonstrate changes in EEG parameters during monotherapy with atypical antipsychotics and indicate their dose-dependent effect on the bioelectrical activity of the brain.
Monogenic diseases associated with cardiomyopathy genes and their phenotypic manifestations
Authors: Kucher A. N. , Nazarenko M. S.
Published: April 2024

The aim of the present study was to summarize the data on the spectrum of genetic diseases and their phenotypic manifestations in case of structural and functional defects in 75 genes, pathogenic variants of which are associated with the formation of different types of cardiomyopathy (CMP). The search for scientific publications was carried out in foreign (PubMed) and Russian (eLibrary) digital libraries. The data analysis was performed using the Simple ClinVar, An Online Catalog of Human Genes and Genetic Disorders, and STRING databases.

It was shown that the vast majority of CMP genes are pleiotropic. Monogenic diseases caused by mutations in CMP genes are characterized by a wide range of pathological manifestations in various organs and systems (cardiovascular, nervous, endocrine, musculoskeletal systems, connective tissue, skin and appendages, organs of vision and hearing, kidneys) as well as by metabolic and immune disorders. Therefore, if a patient (regardless of the primary diagnosis) has pathogenic / likely pathogenic variants or variants of uncertain significance in the CMP genes, we recommend a detailed and comprehensive clinical examination. This is important for clarifying the effects of rare genetic variants, identifying significant clinical and prognostic features for CMP and monogenic diseases associated with CMP genes, and identifying risk groups and controllable triggers that contribute to the manifestation of pathogenic genetic variants.
Features of the lung microbiota in tuberculosis infection
Authors: Orlova E. A. , Ogarkov O. B. , Kolesnikova L. I.
Published: April 2024

Normal lung microbiota is a small number of transient microbes; however, respiratory pathology may be associated with persistent microbial colonization of the lungs. It remains a poorly understood and mysterious part of the pathogenesis of tuberculosis infection.

The review considers the general pathogenetic mechanisms of the effect of lung microbiota in respiratory pathology and presents the main methodological difficulties in the study of the lung microbiome. This review is aimed at analyzing the results of the available studies on diverse microbial composition of human lungs in tuberculosis using metagenomic sequencing methods. Despite high variability of the presented data, we can conclude that dysbiosis in tuberculosis is more often characterized by a decrease in bacterial diversity and enrichment of lung microbiota with anaerobic bacteria. Acinetobacter, Campylobacter, Moraxella, Pseudomonas, Staphylococcus, and Streptococcus, as well as some other microorganisms are indicated as important pathogenetic factors of dysbiosis in pulmonary tuberculosis, the role of which is yet to be elucidated.
Oxidative phosphorylation in brown adipose tissue in a type II diabetes mellitus mouse model after forced treadmill running
Authors: Zakharova A. N. , Milovanova K. G. , Orlova A. A. , Kollantay O. V. , Shuvalov I. Yu. , Kapilevich L. V.
Published: April 2024

Aim. To study the effect of forced exercises on the content and parameters of oxidative phosphorylation in brown adipose tissue of mice with type II diabetes mellitus.

Materials and methods. To model the disease, we used a high-fat diet and physical exercises in the form of forced treadmill running for 4 weeks. The content of oxidative phosphorylation enzymes in brown adipose tissue was determined by Western blotting.

Results. Modeling diabetes in experimental animals was accompanied by expansion of adipose tissue. However, in brown adipose tissue, the content of all oxidative phosphorylation components decreases. Apparently, during type II diabetes mellitus modeling in mice, there is a decrease in the “energy efficiency” in brown adipose tissue, which is partially offset by an increase in its content in the body. Regular physical activity in mice with type II diabetes mellitus, in contrast to healthy animals, contributes to a decrease in the content of brown adipose tissue. At the same time, the content of most oxidative phosphorylation components in brown adipose tissue increases, in some casesб it even exceeds the baseline values. The latter is typical of a variable load mode – when the execution time of exercises periodically changes.

Conclusion. The obtained results suggest that metabolic rearrangements in brown adipose tissue may serve as some of the mechanisms of preventive and projective effects of physical activity in type 2 diabetes mellitus.
Reflection of experiences with academic supervisors, supervisees and issues of power
Authors: Odularu O.I. , Akande J.O
Published: April 2024

Academic supervision is essential for developing students’ careers and educational advancement. The systematic review approach was chosen for the methodology of this study. It has been observed in the literature that there are positive and negative experiences between supervisees and their supervisors. This led to the research gap in the study, which stated that supervisors and their supervisees are inadequately prepared for their roles. The study addressed these gaps through a systematic review of the article sub-topics. The conceptual model was adopted for this article, and it articulates how supervisors can exhibit their dispositional qualities. Additionally, this article recommends enhancing creative and innovative research to intensify a sense of autonomy and periodically updating research instructions on actualising the vision and mission statements of Higher Educational Institutions (HEIs). The study further recommends that training initiatives for supervisors should be encouraged in HEIs through academic research groups, among others.
The Role of Perioperative Nutritional Status and Supplementation in Orthopaedic Surgery
Authors: Tedesco Amanda , Sharma Abhinav K. , Acharya Nischal , Rublev George , Hashmi Sohaib , Wu Hao-Hua , Lee Yu-Po , Scolaro John , Bhatia Nitin
Published: April 2024

» Identification of malnourished and at-risk patients should be a standardized part of the preoperative evaluation process for every patient.

» Malnourishment is defined as a disorder of energy, protein, and nutrients based on the presence of insufficient energy intake, weight loss, muscle atrophy, loss of subcutaneous fat, localized or generalized fluid accumulation, or diminished functional status.

» Malnutrition has been associated with worse outcomes postoperatively across a variety of orthopaedic procedures because malnourished patients do not have a robust metabolic reserve available for recovery after surgery.

» Screening assessment and basic laboratory studies may indicate patients' nutritional risk; however, laboratory values are often not specific for malnutrition, necessitating the use of prognostic screening tools.

» Nutrition consultation and perioperative supplementation with amino acids and micronutrients are 2 readily available interventions that orthopaedic surgeons can select for malnourished patients.
Management of Bone Loss in Posterior Glenohumeral Shoulder Instability
Authors: Testa Edward J. , van der List Jelle P. , Waterman Brian R. , Caldwell Paul E. , Parada Stephen A. , Owens Brett D.
Published: April 2024

» Posterior glenohumeral instability is relatively uncommon compared with anterior instability, but is becoming an increasingly recognized and surgically managed shoulder pathology.

» Soft-tissue stabilization alone may not be sufficient in patients who present with substantial bone loss to the posterior glenoid and/or the anterior humeral head.

» For posterior glenoid defects, posterior glenoid osteoarticular augmentation can be used, and posterior glenoid opening wedge osteotomy can be considered in cases of posterior instability with pathologic retroversion.

» For humeral head lesions, several surgical treatment options are available including subscapularis transposition into the humeral head defect, autograft or allograft reconstruction, humeral rotation osteotomy, and shoulder arthroplasty.
Decoding MSME Entrepreneurship: A Study from Bogor, Indonesia
Authors: Palahudin  , Ayu pramestidewi Chandra , Awa  , Yulianingsih
Published: April 2024

This research explores the entrepreneurial behavior characteristics of MSMEs in Nagrak Village, Bogor, aiming to provide empirical insights that guide MSME actors in enhancing their business success. Employing a survey method with a descriptive analysis approach, data was collected through observation, interviews, and questionnaires from 27 MSME entrepreneurs. Results indicate that MSMEs in Nagrak exhibit generally strong entrepreneurial behavior, with respondents showing high levels of entrepreneurial knowledge, positive mental attitudes towards entrepreneurship, and proficient entrepreneurial skills. These findings underscore the importance of nurturing knowledge, attitude, and skills in entrepreneurship to foster successful MSME businesses. The study offers valuable input for MSME entrepreneurs in Nagrak, suggesting areas of focus to further improve their entrepreneurial endeavors and achieve business success.
Application of Cole Plot to Better Estimate Reserves in a Complex, Multi Layered, Water Drive Gas Reservoir
Authors: Tamara Wulandari
Published: April 2024

Sisi Nubi is a gas field within the Mahakam PSC operated by Pertamina. The field is compartmentalized by several faults, which subdivide the field into several panels. Reservoirs in Western panel are generally supported by a very active aquifer, while the Central panel generally has depletion drive mechanism. The field consists of 69 geological layers, and over 300 Geological Pressure Unit (GPU), with lateral and vertical pressure communication which is difficult to predict.

In addition to the given complex context, each well in this field is producing in commingle from multiple reservoirs. The majority of Sisi Nubi production comes from fluvial channel sand reservoirs (Fresh Water Sand interval), with good lateral connectivity and excellent petrophysical properties. This production mode gives rise to many interference effects between wells (laterally), and/or within the well (vertically), which will affect CGIP calculation dynamically over production time in each well.

Properly quantifying aquifer strength is one of the main challenges to accurately determine reserves. A gas reservoir with transient aquifer support can plot as a near straight line on a P/Z plot, masking the existence of an active aquifer, and causing significant overestimation in gas reserves.

Cole Plot is useful to distinguish aquifer support effect in CGIP estimation by including water entry effect in the material balance. A simple phenomenological model has been created and tested to check the application of Cole Plot to estimate reserves estimation in a complex multi layered gas field.

The result shows that the volume estimation in the complex multi layered gas field can be estimated using Cole Plot formula. The study also enables us to understand various shapes in Cole Plot application based on real production data.

This study is the first application of Cole Plot to measure interference effect in a complex mature field with a commingle multi-layer production, and lateral connectivity. This method also enabled us to quantify the aquifer effect bias in estimating the CGIP value, with a simple tool in a relatively short period of time.
Schwann Cell C5aR1 co-opts Inflammasome NLRP1 to Sustain Pain in a Mouse Model of Endometriosis
Authors: De Logu Francesco , Titiz Mustafa , Landini Lorenzo , de Araujo Daniel Souza Monteiro , Marini Matilde , Seravalli Viola , Chieca Martina , Pensieri Pasquale , Montini Marco , De Siena Gaetano , Pasquini Benedetta , Vannuccini Silvia , Iannone Luigi , Brancolini Giulia , Bellantoni Elisa , Scuffi Irene , Mastricci Alessandra , Tesi Martina , Tommaso Mariarosaria Di , Petraglia Felice , Geppetti Pierangelo , Nassini Romina
Published: April 2024

Over 60% of women with endometriosis experience abdominopelvic pain alongside pain in other areas of the body, such as chronic back pain, fibromyalgia and chronic fatigue, vulvodynia, and migraine. Although the imbalance of proinflammatory mediators, including the complement component C5a, has been implicated in endometriosis-associated pain symptoms, the mechanisms causing widespread pain and the role of C5a remain unclear. Female mice with endometriotic lesions displayed widespread pain and increased plasma C5a levels, similarly, observed in women with endometriosis. We hypothesized Schwann cells involvement in endometriotic pain. Silencing the C5a surface receptor (C5aR1) in mouse Schwann cells abolished C5a-induced activation of NLRP1 inflammasome and the ensuing interleukin-1β (IL-1β) release. IL-1β, from Schwann cells, recruited macrophages in sciatic/trigeminal nerve trunks. Macrophages induced oxidative stress, targeting proalgesic TRPA1, causing widespread mechanical allodynia. This pathway, initiated by C5aR1, engages Schwann cell signaling, including NLRP1/IL-1β/macrophages/oxidative stress/TRPA1, sustaining pain in an endometriosis mouse model.
Effect of Ni/Sn Ratio on Microstructure and Properties of Cu-Ni-Sn-P Alloy
Authors: Chen Xiaokang , Xiao Xiangpeng , Yuan Dawei , Chen Jinshui , Wu Yu
Published: April 2024

Cu-1.33Ni-1.35Sn-0.08P(Ni/Sn = 1/1), Cu-0.87Ni-1.82Sn-0.08P (Ni/Sn = 1/2) and Cu-1.78Ni-0.86Sn-0.08P (Ni/Sn = 2/1) alloys were prepared to explore the effect of different Ni/Sn ratios on the microstructure and properties of the alloys. The results showed that the alloy had the best properties when Ni/Sn = 1/2. At peak aging, its tensile strength and conductivity reached 447.3 MPa and 35.5% IACS respectively. Its tensile strength was 65.1 MPa and 88.8 MPa higher than that of the alloys with Ni/Sn = 1/1 and Ni/Sn = 2/1 respectively, and its conductivity was 1.1% IACS and 3.9% IACS higher. All three alloys had obvious dendrite segregation, but the alloy with Ni/Sn = 1/2 had finer dendrites and a more uniform distribution. In addition, the precipitates in the Cu-Ni-Sn-P alloys with Ni/Sn = 1/2 and Ni/Sn = 1/1 were all granular Ni12P5 phases, and the particles of the former are finer. The precipitates in the Cu-Ni-Sn-P alloy with Ni/Sn = 2/1 were rod-shaped. The strengthening mechanisms of the three alloys were Orowan strengthening, grain boundary strengthening, solid solution strengthening and dislocation strengthening, and Orowan strengthening was dominant. The Cu-Ni-Sn-P alloy with Ni/Sn = 1/2 had finer grains and precipitates, resulting in better tensile strength and electrical conductivity.
In situ tracker for brake squeal prediction
Authors: Thévenot Maël , Brunel Jean-François , Brunel Florent , Bigerelle Maxence , Stender Merten , Hoffmann Norbert , Dufrénoy Philippe
Published: April 2024

Most ground transportation vehicles rely on braking systems that involve a sliding contact between a rotating and a stationarypart. In such scenarios, the emission of high-intensity noise, commonly known as squeal, can present human health risksbased on the noise’s intensity, frequency, and occurrences. Despite the importance of squeal in the context of advancingurbanization, the parameters determining its occurrence remain uncertain due to the complexity of the involved phenomena.This study aims to identify a relevant operando indicator for predicting squeal occurrences. To this end, a pin-on-disc test rigwas developed to replicate various contact conditions found in road profiles and investigate resulting squealing. Each testinvolves thermal and mechanical instrumentation, complemented by surface observations. Thermo-mechanical phenomenaand tribological behavior of the contact are investigated to highlight the relevance of the proposed indicator by establishing linksbetween contact conditions and squealing.
Urbanization decreases richness but not the phylogenetic and functional diversity of bees
Authors: Moreno-García Pablo , Ponisio Lauren , Li Daijiang
Published: April 2024

Urbanization has been documented as a major factor affecting worldwide biodiversity. Such evidence, however, mostly came from studies of plants and birds, with the response of many taxa to urbanization unclear. For example, both increases and decreases in bee diversity with urbanization have been reported. Such studies mainly focused on a small number of cities, with no study attempting to assess the patterns of bee diversity with urbanization at large spatial scales. To fill this knowledge gap, we leveraged global bee occurrence data to quantify species richness, phylogenetic diversity, and functional diversity of bees across Canada and the United States. We analyzed the effects of urbanization, climate, and agriculture on bee diversity while controlling for the number of records, ecoregion, and spatial correlations. We found that bee richness decreased with urbanization. In addition, urbanization led to the loss of redundant phylogenetic lineages, increasing the phylogenetic distances among closely related species. Urbanization also increased the occurrence of species with uncommon functional traits, increasing functional diversity. Future studies should expand these analyses to more regions, including the speciose areas across Mediterranean climates, as well as Tropical regions.