bluuebunny/crossref_metadata_2025 huggingface dataset:
Lipólise enzimática e mecânica nas regiões submentoniana e submandibular. Uma revisão bibliográfica integrativa
Authors: Rizzatti-Barbosa Célia Marisa , Paiva Rosemary Cordeiro de , Virgens Ana Paula Almeida das , Albergaria-Barbosa José Ricardo de
Published: January 2025

O aumento do volume da região submentoniana pode estar associado a diversos fatores, tais como condições genéticas, posicionamento dos ossos da maxila e mandíbula e acúmulo de gordura na região. O acúmulo de tecido adiposo nessa área gera o excesso de pele e tecido adiposo sob a mandíbula, causando o aspecto de queixo duplo. Este aspecto pode levar os pacientes a buscarem por procedimentos para melhorar sua estética no pescoço. Soluções para este problema poderiam ser a redução da papada através de lipólise enzimática ou mecânica, através de procedimento estético para remoção mecânica de tecido adiposo submentoniano. Objetivo. Este trabalho foi revisou a literatura integrativa sobre o uso da lipólise de papada enzimática e a remoção mecânica. Metodologia. Foi realizado um levantamento de artigos publicados durante o período de 2006 a 2024, em português e inglês, que abordaram as duas técnicas. Resultados. Cento e quatro estudos foram encontrados nos bancos de dados. Após a exclusão por duplicação, análise de títulos, resumos e textos incompletos, apenas 7 artigos preencheram os critérios de elegibilidade. A lipoaspiração de papada, subdividida em técnicas mecânicas e enzimáticas foram descritas com frequência similar, dependendo da indicação e protocolo técnico. Conclusão. Ambas as técnicas são boas para controlar a redução de gordura submentoniana com objetivo de obter um contorno mais harmonioso da região, sendo eficaz dentro da Harmonização Orofacial, quando bem indicada e bem realizada.
Uso de antirretrovirais em gestantes vivendo com HIV no Brasil: Coorte retrospectiva, 2014-2019
Authors: Lima Solange Cristina Teixeira de , Braga Maria das Graças , Mendes Jullye Campos , Ferraz Matheus Marchesotti Dutra , Melo Pedro Olmo Stancioli Vaz de , Silveira Micheline Rosa
Published: January 2025

No Brasil, o HIV em mulheres ocorre principalmente na fase reprodutiva, com aumento das taxas de detecção entre gestantes. Alterações nos protocolos de terapia antirretroviral (TARV) têm influenciado o manejo das gestantes vivendo com HIV (GVHIV). Objetivo: Avaliar o uso de antirretrovirais (ARVs) e o perfil sociodemográfico das GVHIV no Brasil entre 2014 e 2019. Métodos: Estudo de coorte retrospectivo com dados do Sistema de Controle Logístico de Medicamentos (SICLOM). Foram incluídas mulheres com 14 anos ou mais e ao menos uma dispensação de ARV durante a gestação. As gestantes foram classificadas entre usuárias prévias de TARV e iniciantes na gestação. Análises descritivas e analíticas foram realizadas. Resultados: Incluíram-se 34.659 gestantes: 53,3% usaram TARV previamente e 46,7% iniciaram na gestação. A maioria tinha 30-39 anos (32,6%), era não branca (46,7%), sem parceiro (38,5%) e com 8-11 anos de estudo (27,7%). O tempo médio de TARV foi de 174,2 dias, com 14,3% relatando reações adversas. Os esquemas de ARVs variaram: lopinavir + ritonavir/zidovudina + lamivudina até 2016, tenofovir + lamivudina + efavirenz em 2017, e tenofovir + lamivudina/raltegravir a partir de 2018. Conclusão: O uso de TARV entre GVHIV seguiu os protocolos nacionais, refletindo práticas consistentes. Contudo, os dados destacam vulnerabilidades sociais e a necessidade de ampliar o acesso à saúde. Melhorar os serviços de saúde reprodutiva é essencial para reduzir a transmissão vertical e garantir cuidado integral.
Desenvolvimento e implementação de um protocolo de cuidados de enfermagem para pacientes com dispositivo de assistência ventricular HEARTMATE 3
Authors: Carvalho Manoel dos Santos , Souza Vitória Fagian de , Gentil Selma Rossi , Procopio Camila Batella , Marcelino César Augusto Guimarães , Simonetti Sérgio Henrique
Published: January 2025

O presente estudo tem como objetivo descrever o processo de implementação de um Procedimento Operacional Padrão (POP) relativo à assistência de enfermagem aos pacientes com dispositivo de assistência cardíaca HeartMate III. Trata-se de um estudo descritivo do tipo metodológico, onde foi elaborado um POP relacionado à assistência de enfermagem aos pacientes com dispositivo de assistência cardíaca HeartMate III em um hospital público de grande porte especializado em cardiologia. Foi desenvolvido pelo Serviço de Educação Continuada - Divisão de Enfermagem após constatação da necessidade da implementação e capacitação dos profissionais de enfermagem em relação à assistência aos pacientes submetidos ao implante do dispositivo. O estudo aponta que os profissionais de enfermagem necessitam dispor de conhecimentos consistentes sobre as técnicas e manipulação dos dispositivos de assistência cardíaca. O desenvolvimento e implementação deste protocolo promoveu maior segurança aos usuários e profissionais de saúde, garantindo a redução da variabilidade de ações de cuidado, melhorando a qualificação dos profissionais para a tomada de decisão assistencial, facilitando a incorporação de novas tecnologias do cuidado e assim garantindo maior transparência. Assim, o POP entra como uma estratégia gerencial para os profissionais garantirem a qualidade do atendimento e a padronização das ações de enfermagem.
Fontes de poder dos entregadores de aplicativo
Authors: Liberato Leo Vinicius Maia , Schmidt José Renato Alves
Published: January 2025

Historicamente a organização e luta coletiva dos trabalhadores tem constituído um importante fator de melhoria ou manutenção do ambiente e das condições de trabalho. Embora na última década tenham sido registradas diversas lutas dos trabalhadores de plataforma digitais, em particular dos entregadores de aplicativo, poucas tiveram conquistas duradouras. O objetivo do presente artigo é apresentar um estudo de revisão sobre as fontes de poder dos entregadores de aplicativo, utilizando os conceitos de poder estrutural e poder associativo. Por fim tratamos de três casos em que as lutas dos entregadores buscaram atingir também ativos intangíveis das empresas o Breque dos Apps no Brasil em 2020; a luta na Oferta Inicial de Ações da Deliveroo no Reino Unido em 2021; e a luta dos entregadores do eFood na Grécia também em 2021. As discussões se baseiam principalmente em revisão bibliográfica narrativa em inglês e português sobre formas de organização e lutas dos entregadores de aplicativo no Brasil e no mundo. As principais conclusões são que os entregadores possuem baixo poder estrutural, com poder associativo ainda insuficiente para mudanças significativas nas condições de trabalho e remuneração. Além disso, atingir o efeito de rede dessas empresas já se mostrou possível e estratégico para exercer poder sobre elas.
Impactos da polifarmácia em adultos jovens usuários de antidepressivos: Uma revisão sistemática
Authors: Paulino Débora Sinara , Sousa Leonardo Carvalho de , Sobrinho Ana Beatriz de Castro , Rodrigues Glenda Glayce Pereira , Lacerda Lorenna Lúcio , Ataide Andre Rodrigues , Nunes Lavynia Ferreira , Pereira Ana Beatriz Scarparo , Xavier Daniella Cristina Silva
Published: January 2025

A polifarmácia, definida como o uso concomitante de cinco ou mais medicamentos, é um fenômeno crescente, especialmente em adultos jovens com condições psiquiátricas que utilizam antidepressivos. Essa prática, impulsionada por diretrizes terapêuticas e diagnósticos precoces, está associada a um risco elevado de interações medicamentosas adversas e efeitos colaterais significativos. Objetivo: Investigar os impactos da polifarmácia em adultos jovens usuários de antidepressivos, com foco em interações medicamentosas e desfechos clínicos. Metodologia: Realizou-se uma revisão sistemática, seguindo as diretrizes PRISMA. As buscas foram conduzidas nas bases de dados PubMed, BVS e CENTRAL Cochrane, abrangendo o período de 2019 a 2024, que abordassem a relação entre polifarmácia e o uso de antidepressivos em adultos jovens. Resultados: Inicialmente, foram identificados 61 estudos, dos quais 12 atenderam aos critérios de inclusão. Os desfechos relatados incluíram: maior risco de arritmias cardíacas, aumento da ideação suicida e tentativas de suicídio, piora do metabolismo dos antidepressivos, hipoglicemia, quedas, mortalidade, eventos gastrointestinais, menor adesão ao tratamento e maior incidência de diabetes mellitus. Mulheres e indivíduos de classes socioeconômicas mais baixas apresentaram maior prevalência de polifarmácia. Conclusão: A polifarmácia em adultos jovens que utilizam antidepressivos está associada a uma série de desfechos adversos, comprometendo a eficácia terapêutica e a segurança dos pacientes. Destaca-se a importância do monitoramento rigoroso, da individualização do tratamento e da investigação detalhada das interações medicamentosas pelos profissionais de saúde.
Relação entre Violência Obstétrica e Depressão Puerperal: Uma revisão integrativa de literatura
Authors: Silva Isabela Cristina Silva da , Ganzer Deborah Victória dos Santos , Azevedo Juliane da Silva , Gonçalves Luídi Lobato , Santos Sofia Brígida Anjos dos , Neder Patrícia Regina Bastos
Published: January 2025

Introdução: A violência obstétrica foi reconhecida como problema de saúde pública. As consequências desse cenário desumanizador frequentemente incluem a depressão pós-parto (DPP), visto que o caráter multifatorial desse transtorno possivelmente torna o desrespeito e o abuso durante o parto alguns de seus fatores desencadeantes. No entanto, a relação entre esses fenômenos precisa ser melhor esclarecida. Assim, objetiva-se sintetizar e analisar criticamente as evidências disponíveis sobre a relação entre violência obstétrica e a ocorrência de depressão puerperal. Metodologia: Procede-se a uma revisão integrativa de literatura, orientada pelas recomendações de Mendes (2008). Realizou-se o levantamento bibliográfico na plataforma BVS e nas bases de dados PUBMED, SciELO, LILACS e SCOPUS, utilizando descritores extraídos da plataforma DECS/MESH. Resultados: Doze artigos foram selecionados para análise completa. Dez estudos evidenciaram uma ligação entre violência obstétrica e depressão pós-parto. Discussão: A gravidez e o puerpério são períodos de risco aumentado para distúrbios psiquiátricos e, somado a violência e maus-tratos, a incidência de depressão pós-parto (DPP) aumenta. A DPP também pode afetar a criança, prejudicando o desenvolvimento e o vínculo com a mãe. Entretanto, é comum que o profissional não se identifique como o agressor, sendo necessário uma reformulação da assistência obstétrica para reduzir os impactos negativos e promover um parto humanizado. Conclusão: A violência obstétrica pode ser um dos principais fatores agravantes para a ocorrência de depressão pós-parto (DPP).
INVESTIGATION OF DNA GYRASE RESISTANCE GENES IN ACINETOBACTER BAUMANNII ISOLATES
Authors: Kayiş Uğur , Sipahi Tammam , Ökten Suzan , Kaynak Onurdağ Fatma
Published: January 2025

Objective: It is known that bacteria resistant to antimicrobial agents can spread to the community in the hospital environment. Acinetobacter baumannii is a difficult-to-treat pathogen due to its antibiotic resistance genes. It is resistant to many antibiotics, including fluoroquinolones. By identifying mutations in DNA gyrase and topoisomerase IV genes, quinolone resistance of A. baumanni is found. Our study, aimed to determine mutations in DNA gyrase resistance genes that cause quinolone resistance (gyrA, gyrB, parC) in A. baumannii isolates using the real-time PCR method.
Material and Method: 73 A. baumannii resistant clinical isolates were used in the study. A. baumannii was amplified using primers for gyrA, parC, gyrB genes. Using HRM analysis, gyrA, gyrB, parC gene Real-Time PCR amplicons were grouped according to their DNA sequences. A. baumannii isolates were grouped as P1, P2, P3, GA1, GA2, GA3, GB1 and GB2 according to different HRM profiles, DNA sequence analysis of 2 different Real-Time PCR products from each group was performed.
Result and Discussion: Mutations were detected in GA1, GA2, GA3 genotypes. No mutations were observed in the P1, P2, P3 and, GB1, GB2 genotypes.
CISTUS CRETICUS L.: ANTIOBESITY, ANTIMICROBIAL AND ANTIBIOFILM PROPERTIES
Authors: Can Agca Asli , Altay Derya , Karaca Başar , Ozdas Sibel , Canatar İpek
Published: January 2025

Objective: Cistus creticus L. is widespread in the coastal regions of Türkiye. In this study, we investigated the cytotoxic, antiobesity, antimicrobial and antibiofilm properties as well as the total phenolic and flavonoid content of both aqueous and ethanolic extracts in vitro.
Material and Method: Two different extracts were prepared from the flowering aerial parts of Cistus creticus using ethanol and water. The total phenolic content and total flavonoids were determined by the Folin-Ciocalteu method and the aluminum chloride colorimetry, respectively. The effect of extracts on the cell viability of 3T3-L1 was determined by methyl thiazole tetrazolium (MTT), and the evaluation of differentiation and the effects of the plant extracts on lipid accumulation in 3T3-L1 adipocytes was performed by Oil-Red O staining. In addition, MIC values and antibiofilm activities were also investigated.
Result and Discussion: The total phenol content of the EtOH and water extract was determined to be 134.2849 mg GAE/g and 96.1803 mg GAE/g, respectively. The total flavonoids in the water and EtOH extracts were found to be 33.1942 mgQE/g and 22.8338 mgQE/g, respectively. The lowest MIC values were determined for the strains Bacillus subtilis DSM 1971, Bacillus licheniformis DSM 13 and Bacillus amyloliquefaciens DSM 7, while the highest MIC concentration was found for the strains Escherichia coli and Eenterococcus gallinarum. The MIC/16 concentration of Pseudomonas aeruginosa ATCC 27853 and Escherichia coli ATCC 25922 also proved to be effective in inhibiting biofilm formation. We observed that noticeable but not strong effects on lipid accumulation were observed in 3T3-L1 adipocytes treated with EtOH extract.
Penguatan UMKM Kesenian melalui Digitalisasi Penyewaan Baju Adat Berbasis CodeIgniter di Sanggar Riak Renteng Tingang
Authors: Agung Prabowo  , Diki Hidayat  , Norhayati  , Windiarti Ika Safitri
Published: January 2025

Strengthening traditional art MSMEs through digitalization is a strategic effort to enhance operational efficiency and competitiveness. Sanggar Riak Renteng Tingang, engaged in traditional costume rental in Central Kalimantan, faces various challenges due to manual processes, such as recording errors, difficulties in stock tracking, and inefficiencies in customer data management. Through this community service initiative, a web-based rental information system was developed using the CodeIgniter framework with the waterfall development method and PIECES analysis. The development stages included needs analysis, system design, implementation, testing, and user training. As a result, the system provides features such as stock management, online booking, and integrated customer data recording, improving accuracy, efficiency, and operational transparency. This digitalization simplifies rental management, enhances customer satisfaction, and supports the sustainability of Sanggar Riak Renteng Tingang’s business. The developed system not only addresses operational challenges but also serves as a model for empowering other art MSMEs to adapt to the digital era. With this implementation, Sanggar Riak Renteng Tingang can become more competitive and contribute to the preservation of local culture through technological optimization.
Generasi Peduli: “Menciptakan Sekolah Bebas Bullying dan Rokok di SDN 33 Waimnir Kab. Raja Ampat "
Authors: Muharuddin  , Marlinda Indah Eka Budiarti  , Irna Rusani  , Achmad Rusdi  , La Robi  , Hidayani  , Ainun Mardiah  , Aswad Muhdar  , Muhammad Ali
Published: January 2025

Di tengah perkembangan sosial dan teknologi yang pesat, generasi muda dihadapkan pada berbagai tantangan, termasuk bullying dan konsumsi rokok, yang dapat mempengaruhi kualitas hidup mereka secara signifikan. Bullying, baik secara fisik, verbal, maupun sosial, dapat menyebabkan dampak psikologis yang mendalam, seperti penurunan kepercayaan diri dan stres, sehingga mempengaruhi kesejahteraan anak-anak dalam lingkungan pendidikan dan sosial mereka. Konsumsi rokok, di sisi lain, tetap menjadi masalah kesehatan yang serius di kalangan anak-anak, meningkatkan risiko penyakit jangka panjang dan mempromosikan pola hidup tidak sehat. Sebagai respons terhadap isu-isu ini, program "Generasi Peduli" dilaksanakan pada 6 Agustus 2024 di SDN 33 Waimnir dengan tujuan memberdayakan anak-anak melalui sosialisasi interaktif yang membahas dampak bullying dan bahaya rokok. Program ini melibatkan berbagai tahapan, termasuk penyampaian materi edukatif, kegiatan ice breaking untuk menjaga semangat, dan sesi tanya jawab untuk memastikan pemahaman siswa. Hasil kegiatan menunjukkan bahwa program ini berhasil meningkatkan kesadaran siswa terhadap isu-isu penting tersebut, dengan partisipasi aktif yang menunjukkan penerimaan dan relevansi materi bagi mereka. Kegiatan ini diharapkan menjadi langkah awal dalam membentuk generasi yang lebih peduli dan sehat.
The Relationship Between Hormonal Contraceptives, Level of Anxiety and Emotional Awareness: Pilot Project
Authors: Kecer S , Pírek O , Budínská X , Světlák M , Kon E , Svačinová J , Greplová K , Valík D , Svízela V , Nováková Z
Published: January 2025

An important part of the side effects of combined oral contraceptives (COC) usage is its psychological impact, which includes mood changes, anxiousness and depression. The psychological impacts are expected to be caused by physiological fluctuations of sex hormone levels during the menstrual cycle; this cycling is, however, suppressed in COC users. In our study, we assessed the differences in emotional awareness and anxiousness between women long term users of anti-androgenic COC (AA) and women with no COC use in their medical history (C). We also searched for intraindividual differences by comparing the results of both groups for the follicular and luteal phase of their cycle. A total of 45 women aged 18 to 22 participated in this study. The respondents were given our battery of questionnaires at the beginning of their follicular phase – this battery included two State-Trait Anxiety Inventory questionnaires (STAI-I, STAI-II), as well as a Levels of Emotional Awareness Scale (LEAS) test. The respondents were given only STAI-I in their luteal phase. We also analyzed the hormonal profile of our respondents. Our results show a significant difference in the LEAS analysis, implying the possibility of altered emotional awareness in AA group. STAI-I and STAI-II analysis did not yield any significant results, showing that anxiety levels of COC users probably do not differ from the general female population. We therefore discovered lower emotional awareness in COC using women (AA).
Pengembangan Lembar Kerja Peserta Didik (LKPD) Berbasis Host pada Mata Pelajaran Fiqih Kelas X di MA Nuurul Haq Rumbia
Authors: Setiawan Wahyu , Suhono Suhono , Asy’ari Hasim
Published: January 2025

This research aims to develop HOTS-based LKPD in the Fqih subject which is carried out at one of the schools, namely MA Nuurul Haq Rumbia. Students in the 21st century imagine an era of globalization that requires adequate life skills. Problem solving skills are closely related to higher order thinking or HOTS. In the 2013 Curriculum, an educator must be creative in improving the quality of the learning process and must be able to involve student activity which can maximize brain performance so that students' high-level thinking skills can be well received. This research uses the R&D (Research and Development) method with the ADDIE model. one development model used in development. The procedure for implementing this development is carried out in 5 stages, namely: Analysis, Design, Development, Implementation, Evaluation with a validation sheet as a data collection tool from validators and students of class x MA Nuurul Haq Rumbia. The results of this research, produces LKPD products that can be used at the MA/SMA level as teaching materials or handbooks for students that have met the very good criteria with an average score from design experts 92%, material experts 96% in the very appropriate category and the responses given by educators 84% were in the very interesting category, and 96% of small-scale trials were carried out in the very interesting category. LKPD (Learner Worksheet) teaching materials are suitable for use in the learning process.
Keywords: Developing HOTS, Learning Fiqh, Lembar Kerja Peserta Didik
Technical and legal rules of formulating footnotes in laws: theoretical and legal aspects
Authors: Dzeiko Zhanna Oleksandrivna
Published: January 2025

The purpose of this article is a theoretical and legal study of the problems of formulating notes in laws in the context of the application of legislative techniques. Results of the study: the author proposed the basic technical and legal rules for formulating notes in laws. The expediency of using notes in laws is determined by their main function: notes are aimed mainly at specifying the rules of law enshrined in laws. The note in the law is «accompanying» in relation to the rule of law and therefore the content of the note should not go beyond the relevant rule of law. The notes should contain atypical legal provisions that are part of the rule of law, but not independent classical models of the rules of law. The use of notes is necessary when: the laws use ambiguous terms and are required to establish in what sense the term is used in this act; taking into account the purposes of the law being designed, the corresponding concept is specific; it is required to give an official definition of the evaluation concept; it is necessary to clarify various terms, sizes, etc. Notes in the laws should be used only when necessary, however, if possible, it is advisable to avoid their application, not to abuse them. It is advisable not to create too large in volume notes, not to include a few notes in the article of the law, not to use a note to many articles of the law. The use of line notes is not valid. The best option for fixing the relevant provisions of the law is the creation of independent articles or their placement directly in the text of the structural unit to which they relate. When constructing notes-lists in laws, if necessary, it is advisable to indicate whether all its constituent elements or only one or several of the listed are included in the scope of the concept to be defined. If there is a need, it should be indicated whether the components of the list are equivalent or located by priority. The use of exception notes is unacceptable, since the deviation from the general rule formulated in the note actually becomes an independent rule of law, and even more so, is an exception to this rule. The author made a general conclusion that in the field of application of technical and legal rules, the formulation of notes in laws requires a system-wide approach.

Key words: law, legislative technique, means and rules of legislative technique, rules of law, law structure, article of law, footnote.
Reintegration of the population of disputed territories after the military conflicts: legal experience of Azerbaijan and Israel and the prospects for Ukraine
Authors: Tsvetkova Yulianna Volodymyrivna
Published: January 2025

The article examines the state-legal experience of development and implementation of the programs for integration of the population groups of disputed territories in Azerbaijan and Israel, which were previously complicated due to the military conflicts. The analysis of the existing integration programs of both states demonstrates the presence of many common features. In both cases, political and religious rights are guaranteed to the population of the disputed territories, an increase in positive attitude towards the state is facilitated by economic privileges and additional opportunities for economic development of both specific individuals and entire communities. Sufficient emphasis is placed on the youth-oriented cultural and educational opportunities. In order to exercise these rights or to be entitled to the stimuli, certain loyalty or self-identification with the state is required from the population, in particular in the form of acquiring citizenship. The biggest differences in the state and legal policy of both states are related to the fact that Azerbaijan has actually already gained full control over the territory of Karabakh, while in Israel the territorial issue is far from being resolved. It should also be taken into account that Azerbaijan has only two ethno-religious groups related to the territory of Karabakh, and in Israel we are talking about Muslim Arabs, but they belong to three different groups, which is also reflected in the creation of different models when building relations with them Attention is also drawn to the fact that Israel has been pursuing this policy for several decades, while Azerbaijan has just started it. The advantage of the prospects for implementing the population reintegration policy in Azerbaijan is that the military conflict with Armenia over the territory of Karabakh is almost over. Attention is also focused on the different ratio of the population that the state is trying to integrate and the population in the «core» territories of each state. The analysis of the mentioned statistics makes it possible to predict the best prospects for the implementation of the state and legal policy of Azerbaijan. The practice of population integration and reintegration programs is very relevant for Ukraine. After all, the end of the war with the Russian Federation will present our state and society with this problem in its entirety. Today, the task of lawyers-scientists is to study the most successful examples of other states and create developments that could be useful to us.

Key words: disputed territories, policy of integration and reintegration, Azerbaijan, Israel.
Academic Integrity: legislative regulation attempts in the context of Ukraine’s European integration
Authors: Yavir Vera Anatoliivna , Markishev Denys Olegovich
Published: January 2025

The article analyzes one of the legislative attempts to ensure academic integrity at the level of national legislation as a manifestation of legal overregulation, which is generally characteristic of Ukraine. The educational policy and transformation of Ukraine’s educational legislation are significantly influenced by the country’s European integration, which directly affects the education sector, and is also taking place in the context of war. One of the goals of the education and science reform at the current stage of state-building is the integration of Ukraine’s higher education and science into the EU educational and research space. However, the fact that the state is the main driver of reforms and the initiator of legislative changes in the field of education creates a danger of replicating authoritarian culture and attacking academic freedoms and university autonomies, which is the basis of the European Higher Education Area (EHEA). An example of how the state has attempted to curtail these freedoms is the attempt to regulate the fight against academic misconduct at the legislative level. Undoubtedly, the culture of academic integrity improves the quality of education and science, but its formation belongs to the sphere of autonomy and policy of educational institutions, not the state. The Draft Law of Ukraine “On Academic Integrity” No. 10392 of 08.01. 2024 does not regulate relations on ensuring academic integrity; does not meet the goals of Ukraine’s European integration, in particular the achievement and observance of European standards in education (European Higher Education Area), according to which ensuring academic integrity belongs to the sphere of academic freedom of educational institutions, and is not regulated by law; restricts the university autonomy provided for by the Bologna Declaration and the Laws of Ukraine “On Higher Education” and “On Complete General Secondary Education”; contradicts the Constitution of Ukraine. The submitted draft law could be formalized in the form of a policy document - a Concept / program / strategy / white paper / roadmap for the formation of a culture of academic integrity in Ukraine.

Key words: academic integrity, academic freedom, university autonomy, constitutional right to education, discrimination, European integration.
Some issues of early termination of powers of people’s deputies of Ukraine
Authors: Batanova Nataliya Mykolaivna
Published: January 2025

The article deals with the problems of constitutional regulation of the institute of early termination of powers of people’s deputies of Ukraine in the context of foreign experience. The author examines the national and foreign experience of establishing the grounds for constitutional and legal responsibility of people’s deputies at the constitutional and legislative levels and the problems of its implementation in practice. In particular, early termination of the powers of a deputy for failure to comply with the requirements regarding the incompatibility of the deputy’s mandate with other activities; early termination of the powers of a deputy in case of entry into force of a guilty verdict against him/her; early termination of his/her powers as a result of failure to join the deputy’s faction of a political party (electoral bloc of political parties) or resignation from the Verkhovna Rada of Ukraine. The article analyzes the draft law initiatives to supplement Part 2 of Art. 81 of the Constitution of Ukraine with the following grounds for early termination of powers of a people’s deputy of Ukraine: a court determination of the fact of his/her non-personal voting in the Verkhovna Rada of Ukraine, as well as his/her absence without valid reasons at one third of the plenary meetings of the Verkhovna Rada of Ukraine and/or meetings of the committee of the Verkhovna Rada of Ukraine of which he/she is a member during one regular session and improvement of the mechanism of early termination of powers of people’s deputy of Ukraine. The author concludes that the introduction and application of criminal responsibility measures for improper performance of duties by people’s deputies of Ukraine, including in the form of absentee voting, should not replace or exclude their constitutional and legal responsibility, and the main functional purpose is a negative assessment of illegal actions of the authorities. The author emphasizes that improvement of the institution of constitutional and legal responsibility of people’s deputies of Ukraine, procedural regulation of its grounds and sanctions, primarily early termination of their powers, remains a topical issue of constitutional theory and practice. At present, the grounds for early termination of powers of people’s deputies of Ukraine are not clearly defined in the legislation of Ukraine. However, this type of constitutional and legal responsibility is an effective guarantee of the constitutional order, representative democracy and functioning of parliamentarism.

Key words: early termination of powers, constitutional and legal responsibility, people’s deputy of Ukraine, parliament, parliamentarism, constitutional delict, constitutional sanctions, legal responsibility, mechanism of responsibility.
Legal responsibility of the state as a manifestation of its value characteristics
Authors: Varich Olga Hryhorivna
Published: January 2025

The article examines the theoretical and legal foundations of the essence of the legal responsibility of the state as a special institution, which, subject to its proper implementation, is one of the manifestations of the value characteristic of the state. Important in this direction is the institution of legal responsibility of the state to the person, the presence and real implementation of which allows to ensure the guarantee of the rights and freedoms of man and citizen. The institute of legal responsibility is analyzed through the prism of the responsibility of its bodies and officials. In this direction, the value orientations of the state are based on the principles of universal values, follow from social responsibility and receive a manifestation in the unity of rights, obligations of both the state and society. Modern European trends that substantiate the specifics of the institute of legal responsibility are investigated. Thus, the article analyzes the main provisions put forward by the theory of «risk», which implies that the state bears strict responsibility if an official or body of the state commits an unlawful act. The questions of procedural of legal liability related to its implementation, the purpose of which is to ensure the possibility of bringing the state to legal responsibility, are also investigated. The reality of the procedures of legal responsibility of state primarily depends on the availability of justice and bodies exercising state power in other areas.

Key words: state, legal responsibility of the state, legal responsibility of the state to the person, value of the state
Investigation of biocompatibility and angiogenesis in vivo on a model of chorioallantois membrane of a chicken embryo of samples for implantation surgery based on titanium and its alloys
Authors: Botasheva V. S. , Dolgalev A. A. , Christoforando D. Yu. , Garaza S. N. , Vorobyev M. S. , Choniashvili D. Z. , Sadovsky V. V. , Avanisyan V. M. , Gezuyev G. K.
Published: January 2025

In this work, samples for implantation surgery based on titanium and its alloys: VT6, VT6+Ti, VT6+TiO2, VT6+ZrO2 were studied for biocompatibility and angiogenesis in vivo on a model of chorioallantois membrane of a chicken embryo. As a result, quantitative and qualitative characteristics of the conducted studies were obtained, the most suitable conditions and materials for further use in implantation surgery were identified, estimates of the use of materials based on titanium and its alloys were given, and the biocompatibility of samples was summarized.
Materials for the manufacture of dental implants (literature review)
Authors: Yanushevich O. O. , Krikheli N. I. , Peretyagin P. Yu. , Kramar O. V. , Tsitsiashvili A. M. , Aleksashina I. P. , Zhukovskaya Yu. I.
Published: January 2025

The purpose of this study was to analyze various literature sources, giving an exhaustive overview of the characteristics of all structural materials currently used in the manufacture of dental implants, which will also determine the trend of new developments in materials science in dental implantology.

   The research material included literary data presented in scientific publications indexed in the bibliographic databases PubMed, ScienceDirect and E-library, using the keywords isolated and their combinations in Russian and English « dental implants, titanium, zirconium, ceramics, tantalum, biocompatibility, osteointegration, graphene» as search terms. The results showed that the use of all existing materials and technological processes for the production of dental implants is justified. To date, the task of further scientific research in this field is to search for and/ or create a material that meets all the necessary operational requirements for a dental implant, has greater biocompatibility, less toxic effects on the body or its absence, providing optimal functional and aesthetic properties, at the lowest possible cost of manufacturing the product. Studies of ceramic-metal materials with the addition of graphene are promising, as currently studies show its high potential acceptability for integration in the development of new materials and technological processes for the production of dental implants.
New materials for the manufacture of intracanal pins
Authors: Krikheli N. I. , Pustovoit E. V. , Nozdrina M. S. , Rudneva O. V. , Peretyagin P. Yu. , Khodanovich N. V. , Naumenko P. A. , Zhukovskaya Yu. I.
Published: January 2025

The issue of tooth strength loss due to hard tissue loss after endodontic treatment remains relevant. Intracanal pins and cores are widely used for long-term restoration of the anatomical and functional integrity of depulped teeth. Modern studies focus on the multifactorial nature of morphofunctional processes of restoration of lost tissues. The main parameters are the size of the restored crown, the shape of the root canal and the redistribution of occlusal loads. Physicochemical characteristics of pin materials are also important, such as: biocompatibility, strength, elasticity, hypoallergenicity, adhesion quality and aesthetics. Previously, preference was given to metal pins, but they have disadvantages: corrosion, weak connection and low aesthetics, which makes them less attractive compared to modern alternatives.

   In connection with the above, the purpose of this study is to develop a technology for the two-stage manufacture of graphene-containing dental pins using the 3D printing method.

   Materials and methods: The technology for manufacturing dental pins is based on the use of the method of printing monoceramic dental products. The process uses a zirconium suspension, which is a poorly soluble viscous white liquid with a specific odor, with which printing will occur. As part of the development of the technology for producing monoceramic dental products, a large number of dental pins were printed using an additive printer based on selective laser stereolithography. Then, the porous blanks will be pre-functionalized with a suspension of graphene oxide and sintered in vacuum conditions, and will be studied further. Thus, the introduction of 3D printing technology in the process of manufacturing dental pins will open up opportunities for the use of new promising domestic materials in clinical practice.
Effectiveness of removal of retention cysts with localization on the lips using dental diode laser
Authors: Lyubomirskii G. B.
Published: January 2025

The article discusses the etiology, clinical picture, diagnosis and methods of treatment of retention cysts of the minor salivary glands using cutting instruments and a diode laser. Analysis of statistical data shows that retention cysts of the lower lip are the most common form among salivary gland cysts. In the process of surgical treatment of retention cysts using classical cutting instruments, a number of difficulties arise associated with the thin capsule covering the cyst, by breaking through and pouring out the contents, as a result of which complete removal of the cyst is impossible and the appearance of a possible relapse, swelling after such surgery can lead to complications of the nearby salivary glands. Therefore, in a comparative aspect, the effectiveness of laser thermal ablation and the use of adhesive balm (with magnetic polymers, hexethidine, cytylpyridinium chloride and hyaluronic acid) is shown. New possibilities in the treatment of this pathology with minimal risk of complications are presented.
Investigation of the general state of oral hygiene in patients undergoing orthodontic treatment
Authors: Razumova S. N. , Brago A. S. , Nemer A. S.M. , Artemova O. A. , Razumov N. M. , Temejza S. S.M.
Published: January 2025

Relevance. In patients with orthodontic structures, plaque accumulating for a long time around a non-removable device can lead to enamel demineralization, rapidly progressing to a carious cavity and the development of gingival inflammation. An important aspect of the management of such patients is measures to reduce the risk of caries and improve the effectiveness of oral hygiene.

   The aim of the study was to assess the level of oral hygiene in patients undergoing orthodontic treatment in groups with different methods of enamel preparation before fixing braces.

   Materials and methods. A randomized, controlled trial was conducted involving 60 patients aged 18–30 years. To assess the level of oral hygiene and the intensity of caries, we determined: the DMF index, the index of oral hygiene of OHI-S. The assessment of the enamel condition after removal of braces was carried out using the Adhesive Remnant Index (ARI). Universal Bond adhesive system (Tokuyama Dental), SHIELD FORCE PLUS varnish (Tokuyama Dental), double-curing adhesive fixing cement ESTECEM PLUS (Tokuyama Dental) were used to fix the braces. The effectiveness of oral hygiene was evaluated before treatment and 12 months after the start of orthodontic treatment.

   Results. There was a statistically significant decrease in the index of ОНІ-S in patients with ceramic and metal braces, the enamel surface of which was treated with varnish. The index of ОНІ-S before the start of the study in patients with ceramic braces was 1.5 ± 0.12, with metal ones – 1.4 ± 0.47. After 12 months, the index values were 1.6 ± 0.36 and 1.5 ± 0.46, respectively, p = 0.002. In the group of patients whose surface was not treated with varnish, the index values were statistically not significant, p > 0.05. When assessing the resistance of teeth to the development of caries using the DMF index, a statistically significant difference was also found in groups where bracket systems were fixed with pretreatment of the enamel surface with varnish. The value of the DMF index before the start of the study in the group of patients with ceramic braces was 1.7 ± 0.22, in the group with metal braces – 1.4 ± 0.14. After 12 months, the index values were 1.8±0.16 and 1.5 ± 0.23, respectively, p = 0.0012.

   Conclusion. The use of varnish before fixing braces helps to improve the condition of the oral cavity, which is expressed in improved hygiene, as well as in the absence of pathological changes on the enamel surface in the form of demineralization. In this regard, further studies are needed to assess the degree of influence of varnishes on the condition of the oral cavity in patients undergoing orthodontic treatment.
Study of the efficacy of antibacterial tongue foam with cetylpyridinium chloride
Authors: Bessonova E. A. , Kozlov M. E.
Published: January 2025

Relevance. The amount of data on the relationship between the oral microbiome, in particular the tongue, and systemic health is constantly growing, while the impact of various antibacterial agents on this ecosystem remains insufficient.

   Study objective: to evaluate the effectiveness of an antibacterial tongue foam containing cetylpyridinium chloride.

   Materials and methods. The study included 30 patients who were randomized into 3 groups comparable in terms of the initial tongue hygiene index. Group 1 used only a toothbrush and toothpaste without antiseptics for home care, group 2 additionally used a scraper, group 3 – a brush, hygienic paste, scraper and antibacterial foam. All three groups were compared based on the results of assessing the Ulitovsky tongue hygiene index at baseline and 14 days after the appointment of hygiene products. In groups 2 and 3, an additional microbiological study was conducted.

   Results. The study of the results of the index assessment of the hygienic condition of the tongue showed that statistically significant differences were obtained between the beginning of the study and its end in groups 2 and 3, while in group 3 the changes were more pronounced. And when comparing all three groups, reliable differences were obtained between the study groups. The microbiological study of groups 2 and 3 yielded statistically significant differences in the performance of the antibacterial foam in relation to the Enterobacteriaceae family, the Streptococcus family, the Gardnerella vaginalis + Prevotella bivia + microorganism group of the Porphyromonas family, the Peptostreptococcus family, the Candida family, namely, a decrease in their number, according to the quartile analysis.

   Conclusions. The use of antibacterial foam containing cetylpyridinium chloride in combination with the use of a tongue scraper significantly improves the hygienic condition of the tongue and the composition of the microflora.
Features of clinical, radiological and differential diagnosis of productive-destructive form of chronic osteomyelitis
Authors: Trofimov S. A. , Drobyshev A. Y. , Shulakov V. V. , Lezhnev D. A. , Laschuk S. Y.
Published: January 2025

Primary chronic osteomyelitis of the jaw bones is a rare and poorly studied pathology in the maxilofacial region, which causes difficulties in diagnosis, differential diagnosis and treatment. In this regard, the purpose of this study was to identify significant diagnostic and differential diagnostic clinical and radiological criteria in patients with productive-destructive form of chronic osteomyelitis of the jaw bones.

   53 patients with chronic forms of osteomyelitis of the jaw bones were examined and treated. The main criteria that are important in the diagnosis of productive-destructive form of chronic osteomyelitis and comes as basis for planning comprehensive treatment were identified.
Features of clinical, radiological and differential diagnosis of productive-destructive form of chronic osteomyelitis
Authors: Khairoev M. M. , Amkhadova M. A. , Gergieva T. F. , Amkhadov I. S.
Published: January 2025

Issues of diagnosis, treatment, and medical rehabilitation of post-Covid syndrome in the maxillofacial area require further research. Complications after a COVID infection, which mainly affects the respiratory system, are numerous. Factors that determine the development of complications in the maxillofacial area are the virus itself, which leads to a hypercoagulability, and the drugs used in treatment, especially corticosteroids. Also significant are concomitant diseases, especially diabetes. Patients with severe purulent-necrotic lesions of the bones of the facial skull come to maxillofacial clinics.
Implant-prosthetic rehabilitation and ectoprosthetics of a patient with an extensive defect of the right orbit. Clinical case. Part 1
Authors: Put V. , Gladyshev M. , Dolgalev A. , Usatov D. , Svyatoslavov D. , Gorshenin P. , Zhurba I. , Duvidzon V.
Published: January 2025

During operations for the removal of tumors in the maxillofacial region, aesthetic facial defects and functional disorders are formed: disorders of speech, chewing, swallowing and breathing. Removal of the right eyeball and surrounding tissues after combined treatment of basal cell carcinoma of the right orbit led to the formation of a defect that disrupted the patient’s quality of life. Closing the defect by transplanting a combined flap does not make sense in this case. The manufacture of an ectoprosthesis without supporting elements, taking into account the formed anatomy, does not allow to achieve reliable fixation of the ectoprosthesis. The use of adhesive compositions for fixation in this area is extremely limited and rarely used. Rehabilitation of patients with extensive combined defects of the maxillofacial region is carried out using implant-prosthetic structures. A clinical case of ectoprosthetics of the right orbit is presented with a detailed discussion of all aspects of the design, prototyping and manufacture of the prosthesis.
Implant-prosthetic rehabilitation and ectoprosthetics of a patient with an extensive defect of the right orbit. Clinical case. Part 2
Authors: Put V. , Gladyshev M. , Dolgalev A. , Usatov D. , Svyatoslavov D. , Gorshenin P. , Zhurba I. , Duvidzon V.
Published: January 2025

Orbital ectoprosthesis is a complex, multifunctional problem. Removal of the right eyeball and surrounding tissues after combined treatment of basal cell carcinoma of the right orbit led to the formation of a defect that disrupted the patient’s quality of life. The key factor for successful treatment is the area of proper placement of implants in the orbit, taking into account the anatomy of the left eye, deep sinking of the surrounding tissues. The rehabilitation of a patient with a defect in the right orbit was implemented using an implant-prosthetic design. At the stages of treatment, the tasks set were solved and original solutions were developed for the full restoration of aesthetics. A clinical case of ectoprosthetics of the right orbit, aspects of design, prototyping and manufacturing of the prosthesis are presented.