bluuebunny/crossref_metadata_2025 huggingface dataset:
Age and Attitudes Towards an Internet-Mediated, Pedometer-Based Physical Activity Intervention for Chronic Obstructive Pulmonary Disease: Secondary Analysis (Preprint)
Authors: Robinson Stephanie A. , Wan Emily S. , Shimada Stephanie L. , Richardson Caroline R. , Moy Marilyn L.
Published: April 2020

BACKGROUND

Chronic obstructive pulmonary disease (COPD) is prevalent among older adults. Promoting physical activity and increasing exercise capacity are recommended for all individuals with COPD. Pulmonary rehabilitation is the standard of care to improve exercise capacity, although there are barriers that hinder accessibility. Technology has the potential to overcome some of these barriers, but it is unclear how aging adults with a chronic disease like COPD perceive technology-based platforms to support their disease self-management.

OBJECTIVE

Guided by the unified theory of acceptance and use of technology, the current retrospective secondary analysis explores if age moderates multiple factors that influence an individual with COPD’s openness toward an internet-mediated, pedometer-based physical activity intervention.

METHODS

As part of an efficacy study, participants with COPD (N=59) were randomly assigned to use an internet-mediated, pedometer-based physical activity intervention for 12 weeks. At completion, they were asked about their experience with the intervention using a survey, including their performance expectancy and effort expectancy, facilitating conditions (ie, internet use frequency and ability), and use of the intervention technology. Logistic regression and general linear modeling examined the associations between age and these factors.

RESULTS

Participants ranged in age from 49 to 89 years (mean 68.66, SD 8.93). Disease severity was measured by forced expiratory volume in the first second percent predicted (mean 60.01, SD 20.86). Nearly all participants (54/59) believed the intervention was useful. Regarding effort expectancy, increasing age was associated with reporting that it was easy to find the time to engage in the intervention. Regarding facilitating conditions, approximately half of the participants believed the automated step count goals were too high (23/59) and many did not feel comfortable reaching their goals (22/59). The probability of these perceptions increased with age, even after accounting for disease severity. Age was not associated with other facilitating conditions or use of the technology.

CONCLUSIONS

Age does not influence performance expectancy or use of technology with an internet-mediated, pedometer-based physical activity intervention. Age is associated with certain expectations of effort and facilitating conditions. Consideration of age of the user is needed when personalizing step count goals and time needed to log in to the website.

CLINICALTRIAL

ClinicalTrials.gov NCT01772082; https://clinicaltrials.gov/ct2/show/NCT01772082
Telemedicine During the COVID-19 Pandemic: Experiences From Western China (Preprint)
Authors: Hong Zhen , Li Nian , Li Dajiang , Li Junhua , Li Bing , Xiong Weixi , Lu Lu , Li Weimin , Zhou Dong
Published: April 2020

UNSTRUCTURED

Disasters and pandemics pose unique challenges to health care delivery. As health care resources continue to be stretched due to the increasing burden of the coronavirus disease (COVID-19) pandemic, telemedicine, including tele-education, may be an effective way to rationally allocate medical resources. During the COVID-19 pandemic, a multimodal telemedicine network in Sichuan Province in Western China was activated immediately after the first outbreak in January 2020. The network synergizes a newly established 5G service, a smartphone app, and an existing telemedicine system. Telemedicine was demonstrated to be feasible, acceptable, and effective in Western China, and allowed for significant improvements in health care outcomes. The success of telemedicine here may be a useful reference for other parts of the world.
Therapist-Supported Online Interventions for Children and Young People With Tic Disorders: Lessons Learned From a Randomized Controlled Trial and Considerations for Future Practice (Preprint)
Authors: Chamberlain Liam R , Hall Charlotte L , Andrén Per , Davies E Bethan , Kilgariff Joseph , Kouzoupi Natalia , Murphy Tara , Hollis Chris
Published: April 2020

UNSTRUCTURED

In recent years, research into internet-based cognitive behavioral therapy (iCBT) has suggested that therapist-guided digital interventions have greater engagement, adherence, and effectiveness than self-directed digital therapies. While research has focused on the effectiveness of, and adherence to, these interventions, less attention has been paid to their implementation in practice and what aspects of the therapist role support success. An understanding of the key factors related to the therapist role and intervention delivery is required if these iCBTs are to be applied in routine clinical care and outcomes optimized. In light of the coronavirus disease 2019 (COVID-19) pandemic, there is greater emphasis on allowing patients access to remote therapies. We report the experiences and reflections of 4 therapists and their 2 supervisors in delivering an online, therapist-supported intervention in a randomized controlled trial for children and young people with tic disorders (the Online Remote Behavioural Intervention for Tics [ORBIT] trial). Themes discussed include the importance of training, supervision, creating support documents/manuals, and record keeping. Alongside this are communication strategies used by therapists to encourage patient adherence and treatment effectiveness. These include rapport building, treatment personalization, and suggestions for overcoming non-engagement. These reflections offer important considerations for the delivery of iCBTs as well as implications associated with the implementation of these interventions in existing services and future research studies. We share thoughts on where iCBTs may sit in a stepped care model, how services may deal with comorbid conditions, and the potential role of iCBTs in collecting clinical data.
Damshaja Shula: A Review
Authors: Kotnalli Mahadevappa , Gopendra K , Sanath Kumar T , Hussain Gazala
Published: April 2020

Ayurveda has mentioned the bite of Sarpa(snakes), Keeta(incects), Luta(spider), Vrischika(scorpion), Mooshaka(rat), etc., the Jangama Visha (animate poisons), their characteristic symptoms and its management, in a very special branch of Ayurveda termed as Agada tantra. Ayurveda Acharyas have given special attention to Jangama Visha(animate poisons) and are described in the classics as a special entity. Damsha(bite) is the most common in animal poisons. The most common and early symptom is pain. In the management of all types of jangama visha damsha traditional and regional knowledge are available. Administration of anti- venom and sthavaravisha(plant poison) are used as an antidote for all jangama visha damsha. Ayurveda has explained numerous medicinal plants in the management of jangama visha damsha. Pain management plays a major role in management of animal poisoning. Most of the Ayurveda formulations used in management of bite have multiple actions rather than on single symptom like pain.

Keywords: Pain, Sarpa, Keeta, Loota, damsha, Chikitsa
Formulation and Evaluation of Galantamine Hydrobromide Proniosome Gel for Alzheimer’s disease
Authors: Sarfaraz Mohammed , Goel Tanvi , Doddayya H.
Published: April 2020

Galantamine hydrobromide is formulated in tablets and capsules prescribed through oral delivery for the treatment of Alzheimer’s disease. However, oral delivery of drugs can cause severe side effects such as nausea, vomiting, and gastrointestinal disturbance. In the present research work, Galantamine hydrobromide is formulated as proniosome gel by Coacervation phase separation method using different surfactants such as Tweens and Spans. Overall eight formulations were developed and evaluated for various parameters. The prepared gels were viewed by naked eye to observe the colour of gel. Microscopical observations of the gels showed vesicles of optimum size from 3.030 mm (P2) - 3.735 mm (P5). The gel also showed optimum rate of spontaneity in the range 9.60 mm3x1000 (P7) to 11.80 mm3x1000 (P4) and entrapment efficiency of vesicles in the range 66.15% (P5) to 86.92% (P3). The gels had pH in suitable range of skin (5.92-6.9). The in vitro drug diffusion studies revealed that the drug diffusion was affected by the various surfactants used. The rank order of surfactant effect on in-vitro drug diffusion was Tween 80 > Tween 60 > Tween 40 >Tween 20 > Span 80 > Span 60 > Span 40 > Span 20. The proniosomal gel containing Tween 80 showed maximum drug diffusion (99.24%) and the gel containing Span 20 showed minimum drug diffusion (71.74%). FT-IR studies of optimized proniosome gel P8 revealed the absence of any chemical interactions between drug and carriers used.

Keywords: Galantamine hydrobromide, Proniosome gel, Coacervation phase separation method,   Surfactants, in vitro drug diffusion studies.
Nasal In Situ Gel: Novel Approach for Nasal Drug Delivery
Authors: Sabale Anjali Sunil , Kulkarni Abhijeet D , Sabale Ajay Sunil
Published: April 2020

Nasal delivery is an alternative to oral or parenteral administration due to certain limitations such as absorption of the drug, drug targeting to particular organs can cause a problem for administration through oral route.  The nasal route has also been successfully used for bypassing the blood-brain barrier and afterword delivering drug molecules to the central nervous system. Also, lag time related to oral drug delivery is reduces by this route and offers noninvasiveness, self-medication, patient comfort, and patient compliance. Extend drug delivery can be attained by different new dosage forms like in situ gel. In situ formulations are drug delivery systems. The in-situ gelling system is a process in which the solution forms of a gel before administration in the body, but once administrated, it undergoes gelation in-situ, to form a gel. In situ gelling system becomes very popular nowadays because of their several advantages over conventional drug delivery systems like a sustained and prolonged release of a drug, reduced Frequency of administration, improved patient compliance and comfort. Approaches towards the various formulation of in-situ gel concerning temperature, pH, and physicochemical conditions. The in situ gel-forming polymeric formulations offer several advantages like sustained and prolonged action reduced Frequency of administration, in comparison to conventional drug delivery systems.  From a manufacturing point of view, the production of such systems is less complex and thus lowers the investment and manufacturing cost. Various evaluation parameters are considered during the preparation of In-Situ gel.

Keywords: Nasal Drug Delivery, In Situ gel, gelation, polymers, etc
A Pilot Study Indicating Valuation of C‑Reactive Protein for Disease Outcome in Sickle Hemoglobin Patients of Central India
Authors: Dey Sarkar Purnima , Gupta Gajendra Kumar
Published: April 2020

Evidences support the fact that sickle cell disease (SCD) is associated with a chronic inflammatory state characterized by haemolysis. C-reactive protein level (CRP) and white blood cell (WBC) count considered as biomarkers for inflammation. Also, elevation of serum total lactate dehydrogenase (LDH) levels are found to be associated with haemolysis, this makes LDH a nonspecific marker which has to be interpreted in a context of other markers of disease. The present study aims to assess the role of CRP levels, WBC counts, RBC counts, haemoglobin (Hb) concentrations and LDH levels in sickle hemoglobin (HbS) patients. Blood samples of 10 HbS patients (six females and four males) attending M.Y. Hospital, Indore during the period of Aug to Oct 2019 were screened for CRP, LDH and Hb levels and RBC and WBC counts using latex enhanced immune-turbidimetric assay, LDH optimize DGKC kinetic and differential automated hematology analyzer respectively. Data (mean ± SEM) was analyzed using Graphpad Prism software using Tukey’s multiple comparison post-hoc test. The mean Hb levels (7.73 ± 0.81 g/dl) and RBC counts (3.21 ± 0.53 million/µl) were found to be significantly decreased (p˂ 0.001 and 0.01 respectively) and mean WBC counts (15214.28 ± 1893.40 per mm3), CRP levels (85.73 ± 23.23 mg/l) and LDH levels (1334.00 ± 418.49 U/l) were found to be significantly increased (p˂ 0.0001, 0.01 and 0.01 respectively) in HbS patients in comparison with their respective controls. The variations in serum LDH and CRP levels are accompanied by changes in hematological parameters in HbS patients. These parameters may be considered as indicator of the severity of the disease.

Keywords: C-reactive protein, LDH, Sickle cell disease
Excitotoxicity and overnutrition additively impair metabolic function and identity of pancreatic β-cells
Authors: Admin Ada , Osipovich Anna B. , Stancill Jennifer S. , Cartailler Jean-Philippe , D.Dudek Karrie , Magnuson Mark A.
Published: April 2020

A sustained increase in intracellular Ca2+
concentration (referred to herein as excitotoxicity), brought on by chronic
metabolic stress, may contribute to pancreatic b-cell
failure. To determine the additive effects of excitotoxicity and overnutrition
on b-cell function and gene expression, we
analyzed the impact of a high fat diet (HFD) on Abcc8 knock-out mice. Excitotoxicity caused b-cells to be more susceptible to HFD-induced impairment of
glucose homeostasis, and these effects were mitigated by verapamil, a Ca2+
channel blocker. Excitotoxicity,
overnutrition and the combination of both stresses caused similar but distinct alterations in the b-cell transcriptome,
including additive increases in
genes associated with mitochondrial energy metabolism, fatty acid b-oxidation
and mitochondrial biogenesis, and their key regulator Ppargc1a. Overnutrition worsened excitotoxicity-induced mitochondrial
dysfunction, increasing metabolic inflexibility and mitochondrial damage. In addition, excitotoxicity and
overnutrition, individually and together, impaired both
b-cell function and identity by reducing expression of genes important
for insulin secretion, cell polarity, cell junction, cilia, cytoskeleton,
vesicular trafficking, and regulation of
b-cell epigenetic and transcriptional
program. Sex had an impact on all b-cell
responses, with male animals exhibiting greater metabolic stress-induced
impairments than females. Together, these findings indicate that a sustained increase
in intracellular Ca2+, by
altering mitochondrial function and impairing b-cell identity, augments overnutrition-induced
b-cell failure.
O pó da memória: acervo literário de Josué Guimarães e patrimônio cultural
Authors: Andretta Luana Maria
Published: April 2020

Locais de interesse há cerca de um século, os acervos literários vêm se consolidando na contemporaneidade como espaços que congregam memória, história e cultura. Os materiais antes guardados ou destruídos pelos escritores passam a ter uma sobrevida e a serem relidos, repensados e analisados por pesquisadores. Partindo desses pressupostos, o objetivo do presente artigo é o de discutir o acervo literário em três perspectivas independentes: o viés da memória, o da história e o da cultura com base em um relato de experiência ocorrido no Acervo Literário Josué Guimarães (aljog/upf). Por meio de um levantamento bibliográfico, com base, especialmente, em Bordini (1995, 2003), Hay (2007) e Biasi (2010), pudemos perceber que essas três perspectivas sintetizam as múltiplas facetas desse local de investigação multidisciplinar.
Esquemas construcionais no português arcaico: um estudo sobre X-ada1, X-ada2, X-ado, X-do, X-da
Authors: Soledade Juliana
Published: April 2020

O presente trabalho intenta contribuir para a divulgação e avanço do conhecimento linguístico acerca da sufixação no período arcaico da língua portuguesa, a partir de análises que têm como base os aportes descritivistas, cognitivistas e construcionais (BOOIJ, 2010; GONÇALVES, 2016; SOLEDADE, 2013). Uma vez que a sufixação no português arcaico é demasiadamente vasta, neste artigo, iremos tratar dos esquemas sufixais X-ada1 X-ada2, X-ado, X-do, X-da. Para constituir o corpus da primeira fase, observamos fontes secundárias, i.e., glossários elaborados com base em textos do período arcaico do português e, para a segunda fase, fontes primárias, ou seja, edições de textos arcaicos em prosa datados entre o século XV até meados do
Perspectivas onomasiológica e semasiológica nos estudos de neologia
Authors: Maroneze Bruno Oliveira , Ganança João Henrique Lara
Published: April 2020

Este trabalho visa apresentar uma proposta teórico-metodológica de aplicação dos conceitos de onomasiologia e semasiologia para os estudos de neologia. Entendemos que a criação de um neologismo pode ser encarada como um processo onomasiológico (do conceito à denominação) e a interpretação de um neologismo, como um processo semasiológico (da denominação ao conceito). Em outros termos, o criador de um neologismo parte do conceito que tem em mente para encontrar a melhor forma de expressá-lo linguisticamente (onomasiologia); já o decodificador de um neologismo parte de uma expressão neológica para identificar o(s) significado(s) pretendido(s) por ela (semasiologia). Ao analisar o neologismo sob uma ou outra perspectivas, diferentes questões podem ser propostas: a) onomasiologicamente: quais são os recursos linguísticos à disposição do falante para criar um neologismo com o significado pretendido; quais recursos são mais adequados às intenções comunicativas específicas do criador do neologismo; que fatores fonológicos, sintáticos, semânticos, entre outros, influenciam a escolha do mecanismo de criação lexical; e b) semasiologicamente: quais são os significados possíveis de determinado neologismo; de quais mecanismos o ouvinte pode lançar mão para interpretar adequadamente o neologismo; etc. Exemplificamos nossa argumentação com a análise de neologismos integrantes da Base de neologismos do português brasileiro contemporâneo e do corpus composto por textos de blogues jornalísticos diversos que integram a dissertação de Ganança (2017).
Termo de Alinhamento e Vistoria: testemunho do arrendamento do uso do espaço público na Praça São João, Cidade Baixa de Salvador, em 1849
Authors: Van Holthe Jan Maurício
Published: April 2020

O Termo de Alinhamento e Vistoria de julho de 1849, apresentado nessa transcrição, faz parte da coleção de onze volumes encadernados pertencentes ao acervo permanente do Arquivo Histórico Municipal de Salvador (AHMS). Esse manuscrito registra o processo de arrendamento anual de trinta e seis pequenas áreas de comércio exclusivo de gêneros alimentícios no local da antiga Praça São João, situada na Cidade Baixa do município. O documento revela o aluguel concedido a comerciantes livres e cativos(as), especialmente mulheres, citando-os(as) nominalmente, revelando um aspecto interessante da dinâmica social urbana da cidade em meados do século XIX.
A STUDY ON HIGHER SECONDARY STUDENTS EMOTIONAL MATURITY AND ACHIEVEMENT IN ECONOMICS IN TIRUNELVELI DISTRICT
Authors: Rajakumar M
Published: April 2020

The aim of this study is to find out the Emotional Maturity and Achievement in Economics of higher secondary students in Tirunelveli District. 1060 Higher secondary students were taken as sample. The tool used to find out the Emotional Maturity is constructed and standardized by Emotional Maturity Scale Constructed and Validated by K.M.Roma Pal (1984). The Academic achievement in Economics was found out using the tool constructed by the investigator. The mean value of Emotional Maturity scores (136.53) indicates that the higher secondary students are having extremely unstable Emotional Maturity, The mean value of Achievement in Economics scores (M=75.47) indicates that the higher secondary students are having high Achievement in Economics. There is significant difference between male and female, Day scholar and Hostel staying Higher Secondary students with respect to their Emotional Maturity. There is no significant difference between rural and urban, Government and Aided Higher Secondary school students with respect to their Emotional Maturity. There is significant difference between male and female Higher Secondary students with respect to their Achievement in Economics. There is no significant difference between rural and urban, Day scholar and Hostel staying, Government and Aided Higher Secondary school students with respect to their Achievement in Economics.
Contenido polínico de la atmósfera de Estepona (Málaga): año 1996
Authors: Toro F. Javier , Trigo M. Mar , Recio M. , Cabezudo B.
Published: April 2020

En el presente trabajo se realiza un estudio del contenido polínico de la atmósfera de Estepona (sur de España) a lo largo del año 1996. El muestreo aerobiológico se ha realizado con la ayuda de un captador tipo Hirst (modelo VPPS-2000 de la casa Lanzoni), colocado a 14,5 m del nivel del suelo, en el centro de la localidad. Las mayores concentraciones polínicas se registraron durante los meses de Marzo, Abril, Mayo y Junio, periodo en el que se registra casi el 75% del polen total anual, mientras que los meses de Enero, Septiembre y Diciembre fueron los que detectaron menores cantidades dc polen. Los táxones más importantes, en lo que a cantidad de polen se refiere, fueron Cupressaceae, Urtica membranaceay Poaceae, seguidos de Oleo, Quema y Plantago. Los mayores picos de concentración que se produjeron a lo largo del año son debidos principalmente a los aportes de Cupressaceae y Urtica membranacea en Marzo, y Oleo y Poaceae en Junio. En todos los meses del año, exceptuando Marzo y Octubre, existe una mayor relación de pólenes procedentes de plantas herbáceas frente a leñosas, así como de plantas silvestres frente a ornamentales.
Dos orquídeas nuevas para la flora de la Comunidad Valenciana
Authors: Piera Joan , Crespo Manuel B.
Published: April 2020

.
Novedades florísticas para la provincia de Huelva. II
Authors: Santa-Bárbara Consuelo , Valdés Benito
Published: April 2020

.
A generalization of truncated M-fractional derivative and applications to fractional differential equations
Authors: İlhan Esin , Kıymaz İ. Onur
Published: April 2020

In this paper, our aim is to generalize the truncated M-fractional derivative which was recently introduced [Sousa and de Oliveira, A new truncated M-fractional derivative type unifying some fractional derivative types with classical properties, Inter. of Jour. Analy. and Appl., 16 (1), 83–96, 2018]. To do that, we used generalized M-series, which has a more general form than Mittag-Leffler and hypergeometric functions. We called this generalization as truncated ℳ-series fractional derivative. This new derivative generalizes several fractional derivatives and satisfies important properties of the integer-order derivatives. Finally, we obtain the analytical solutions of some ℳ-series fractional differential equations.
Global Attractors for the Higher-Order Evolution Equation
Authors: Pişkin Erhan , Yüksekkaya Hazal
Published: April 2020

In this paper, we obtain the existence of a global attractor for the higher-order evolution type equation. Moreover, we discuss the asymptotic behavior of global solution.
Special Curves According to Bishop Frame in Minkowski 3-Space
Authors: Isah Muhammad Abubakar , Külahçı Mihriban Alyamaç
Published: April 2020

Pseudo null curves were studied by some geometers in both Euclidean and Minkowski spaces, but some special characters of the curve are not considered. In this paper, we study weak AW (k) – type and AW (k) – type pseudo null curve in Minkowski 3-space

E
1
3

[E_1^3

. We define helix and slant helix according to Bishop frame in

E
1
3

[E_1^3

. Furthermore, the necessary and sufficient conditions for the slant helix and helix in Minkowski 3-space are obtained.
FAKTOR-FAKTOR PENERAPAN KESELAMATAN DAN KESEHATAN KERJA YANG MEMPENGARUHI KINERJA PROYEK KONSTRUKSI GEDUNG DI PROVINSI ACEH
Authors: Bunial Bunial , Muttaqin Muttaqin , Rauzana Anita
Published: April 2020

PT. Jamsostek stated that in 2012 everyday there are 9 workers who died due to accidents, while total work accident in the same year recorded 103,000 cases. Accidents to these workers will certainly make the productivity of project work decreased, as well as will impact on the poor performance of the project. This study aims to identify the dominant OSH factors applied in the implementation of building construction projects in Aceh Province, and to analyze the relationship and influence between the factors of OSH implementation on the performance of building construction projects in Aceh Province. This study uses qualitative methods through interviews and quantitative through the distribution of questionnaires. The number of research samples obtained by 68 contractor companies. The sampling technique used is purposive sampling. Data processing methods consist of test validity, and reliability, while data analysis consists of descriptive analysis, simple correlation and multiple linear regression. The results showed that the dominant K3 factor applied in the implementation of the building construction project in Aceh Province was a public protection factor with a mean of 4.632. The safety and work competence factors have a good relationship with Spearman coefficient of 0.451 and 0.429, the factors of equipment and work clothes, vehicle lanes, and equipment and machinery have a low correlation with Spearman coefficient of 0.328, 0.386, and 0.243, while fire, and sound, public protection, general, occupational health, and seriousness of the company have a very low relation with Spearman coefficient of 0.077, 0.130, 0.066, 0.107, 0.121, and 0.169 to the performance of building construction projects in Aceh Province. The influence of OSH implementation factors on the performance of building construction project in Aceh Province, which has significant effect is safety factor, equipment and work clothes, vehicle path, equipment and machinery, public protection, general, seriousness of company, and worker competence with tcount greater than ttable and significance value lower than 0.05.
Cơ sở lựa chọn các biểu thức tính toán sức cản cơ bản đơn vị đầu máy diesel
sử dụng trong ngành đường sắt Việt Nam
Authors: Đỗ Đức Tuấn , Vũ Văn Hiệp
Published: April 2020

Trong ngành đường sắt, để tính toán sức kéo và xác định khối lượng đoàn tàu, cần biết các lực tác dụng lên đoàn tàu trong quá trình vận hành, trong đó có lực cản cơ bản của đầu máy và toa xe. Lực cản cơ bản được xác định thông qua lực cản cơ bản đơn vị. Lực cản cơ bản đơn vị được tính toán thông qua các biểu thức xây dựng trên cơ sở thực nghiệm và được áp dụng cho từng loại đầu máy, toa xe cụ thể. Cho đến nay, trong ngành đường sắt Việt Nam, chưa có điều kiện thử nghiệm để xác định các biểu thức tính toán lực cản cơ bản đơn vị cho đầu máy và toa xe. Vì vậy, việc tính toán sức kéo đều dựa vào các biểu thức thực nghiệm của nước ngoài, khá đa dạng và có những khác biệt đáng kể; đồng thời việc sử dụng các biểu thức đó trong quá trình tính toán chưa có sự thống nhất, chưa thực sự có cơ sở về mặt khoa học. Vì vậy, nội dung bài báo này là tổng hợp, phân tích, thống nhất hóa các mô hình tổng quát về sức cản cơ bản đơn vị của đầu máy, từ đó xác định các biểu thức tính toán sức cản cơ bản đơn vị cụ thể cho các loại đầu máy, làm cơ sở cho việc đề xuất lựa chọn các biểu thức tính toán sức cản cơ bản đơn vị cho đầu máy diesel sử dụng trong ngành đường sắt Việt Nam
Nghiên cứu thực nghiệm liên kết bu lông chịu uốn và cắt đồng thời trong kết cấu thép thành mỏng tạo hình nguội
Authors: Đỗ Văn Bình
Published: April 2020

Bài báo trình bày nghiên cứu thực nghiệm liên kết bu lông trong cấu kiện thép thành mỏng tạo hình nguội (TMTHN) sử dụng bản mã để liên kết các bản bụng của tiết diện chịu tác dụng uốn và cắt đồng thời. So sánh kết quả thực nghiệm về giới hạn bền của liên kết tính theo mô hình phần tử hữu hạn (PTHH) là khá phù hợp. Các kết quả của nghiên cứu cho thấy khi số lượng bu lông, các thông số vật liệu và tiết diện không đổi nhưng tăng khoảng cách bu lông theo chiều dài liên kết thì giới hạn bền uốn cũng tăng đáng kể.
Nghiên cứu mô phỏng tổ hợp chỉnh lưu 12-xung sử dụng cuộn kháng cân bằng trong hệ thống cấp điện kéo cho đoàn tàu đường sắt đô thị
Authors: Phạm Văn Tiến
Published: April 2020

Bài báo nghiên cứu tổ hợp chỉnh lưu 12-xung trong hệ thống cấp điện kéo cho đoàn tàu đường sắt đô thị. Bằng việc phân tích độ lệch pha giữa các điện áp dây của các kiểu đấu dây quấn trong máy biến áp kết hợp với cách đấu ghép các chỉnh lưu cầu ba pha không điều khiển để hình thành tổ hợp chỉnh lưu 12-xung, như vậy điện áp chỉnh lưu phẳng hơn. Trong tổ hợp chỉnh lưu đó, sử dụng máy biến áp ba pha ba cuộn dây nên giảm được không gian lắp đặt, ngoài ra mức độ lợi dụng dung lượng của các chỉnh lưu được nâng cao do khi ghép nối vẫn làm việc độc lập nhờ sử dụng cuộn kháng cân bằng. Phân tích lý thuyết và kết quả mô phỏng đã kiểm nghiệm được tính chính xác và hiệu quả của phương pháp ghép nối.
Punctuation Marks and Signs of Cessation in Qur`an: a comparative study
Authors: Mahmoud-Mukadam Abdur-Rasheed
Published: April 2020

The subject of punctuation in Arabic writing may be one of the topics in which there was a great deal of writing. However, the close look at this paper reveals that there are some new things that the researcher is interested in highlighting in this article. To clarify positions in the Holy Quran. And that some contemporary writers do not take into account the status of these signs and interesting situation in the appropriate places, but they refuse to take into account behind their appearance when writing Arabic became randomly writing, Based on the above, the researcher can shed light on the importance of these punctuation marks and indicate the relationship between them and the signs of the Qur`anic cessation, which does not mean the use of the first place with The existence of the connection and kinship between them; because the writing of Qur`an is descriptive, it could never be treated in the places of cessation and tone as   usual treatment of the normal writing.
ASSESSMENT OF THE EFFECTIVENESS OF PUBLIC CIVIL SERVANTS OF THE RUSSIAN FEDERATION (THEORETICAL AND METHODOLOGICAL FOUNDATIONS)
Authors: Znamenskiy D. Yu. , Gusarov A. V.
Published: April 2020

The content of this article is an analysis of the theoretical and methodological foundations for assessing the professional and service activities of public civil servants in the Russian Federation. The relevance of the article lies in the fact that the ongoing process of transforming public administration and increasing demands from the population to public civil servants requires the development of new methods for of assessing the effectiveness of their activities in the Russian Federation for the successful selection of a modern civil servants who can comply with the growing requirements emanating from population and successfully cope with the assignments and tasks emanating from the country’s leadership. Different theoretical approaches of public administration researchers to assessing the effectiveness of public civil servants have been considered. An analysis of international experience in building and establishing a system for evaluating the effectiveness of public servants will highlight and implement elements of evaluating the effectiveness of public civil servants, taking into account legal, historical and social features of the Russian Federation.
APPLICATION OF ROBOTIC TECHNOLOGY IN THE FASHION INDUSTRY
Authors: Barkova N. Yu.
Published: April 2020

Robotic technology as one of the factors that contribute to the economic growth of Russia has been considered in the article. The strengths and weaknesses, opportunities and threats of robotic technology development in Russia have been analysed. The advantages of use of robots in the fashion industry have been shown. The functioning of the robotic Adidas Speedfactory and some other factories that use in the production process of manufacturing goods of the fashion industry robotic systems, has been studied. The impact of robotic technology on supply chain management in the fashion industry has been assessed. The main reasons for possible changes in global supply chains in the fashion industry have been identified.
Whole Genome Sequence Analysis and Homology Modelling of a 3C Like Peptidase and a Non-Structural Protein 3 of the SARS-CoV-2 Shows Protein Ligand Interaction with an Aza-Peptide and a Noncovalent Lead Inhibitor with Possible Antiviral Properties
Authors: Shanker Arun , Bhanu Divya , Alluri Anjani
Published: April 2020

The family of viruses belonging to Coronaviridae mainly consist of virulent pathogens that have a zoonotic property, Severe Acute Respiratory Syndrome (SARS-CoV) and Middle East Respiratory Syndrome (MERS-CoV) of this family have emerged before and now the SARS-CoV-2 has emerged in China. Characterization of spike glycoproteins, polyproteins and other viral proteins from viruses are important for vaccine development. Homology modelling of these proteins with known templates offers the opportunity to discover ligand binding sites and explore the possible antiviral properties of these protein ligand complexes. Any information emerging from these protein models can be used for vaccine development. In this study we did a complete bioinformatic analysis, sequence alignment, comparison of multiple sequences and homology modelling of the SARS-CoV-2 whole genome sequences, the spike protein and the polyproteins for homology with known proteins, we also analysed receptor binding sites in these models for possible binding with ligands that exhibit antiviral properties. Our results showed that the tertiary structure of the polyprotein isolate SARS-CoV-2_HKU-SZ-001_2020 had 98.94 percent identity with SARS-Coronavirus NSP12 bound to NSP7 and NSP8 co-factors. Our results indicate that a part of the viral genome (residues 3268 -3573 in Frame 2 with 306 amino acids) of the SARS-CoV-2 virus isolate Wuhan-Hu-1 (Genbank Accession Number MN908947.3) when modelled with template 2a5i of the PDB database had 96 percent identity with a 3C like peptidase of SARS-CoV which has ability to bind with Aza-Peptide Epoxide (APE) which is known for irreversible inhibition of SARS-CoV main peptidase. The part of the genome (residues 1568-1882 in Frame 2 with 315 amino acids) when modelled with template 3e9s of the PDB database had 82 percent identity with a papain-like protease/deubiquitinase which when complexed with ligand GRL0617 acts as inhibitor which can block SARS-CoV replication. The regions studied was conserved in more than 90 genomes of SARS-CoV-2. It is possible that these viral inhibiters can be used for vaccine development for the SARS-CoV-2.
Repurposing of SARS Inhibitors Against COVID 19
Authors: Rajbhar Priyanka , Singh Dikshant , Yadav Ruchi
Published: April 2020

Till this date there is no vaccine or drug for coronavirus responsible for COVID-19 which has created a major challenge to stop the spread of disease. Repurposing of a drug could be a solution for this challenge, as many previously available drugs hold great potential to act as a drug molecule. The coronavirus mainly affects the host by binding to its specific receptor with the help of its surface glycoprotein or spike glycoprotein. Thus, interfering this interaction could be a potent mechanism to stop the viral infection and propagation. In this paper, we have discussed about the surface glycoprotein and how previously available drug could be repurposed to act as a potent inhibitor. Homology modelling and docking studies has been mainly done to identify the interaction and binding affinity of previous drugs and how they could act as a potential solution to stop the overall spread of the disease in case of pandemic like COVID-19 where unavailability of specific drug or vaccine is responsible for taking to the lives of many.
Behavior of Volatile Compounds in Membrane Distillation: The Case of Carboxylic Acids
Authors: Khiter Abdelaziz , Balannec Béatrice , Szymczyk Anthony , Arous Omar , Nasrallah Noureddine , LOULERGUE Patrick
Published: April 2020

Thanks to its unique features, membrane distillation (MD) has been particularly applied for desalination but also for niches applications with feed solutions containing a mixture of volatile molecules. For such solutions, the complex interplay of the solutes and solvent physicochemical and operating parameters makes it challenging to predict the separation efficiency by MD. There is thus a need for a better understanding of the behavior of volatile compounds in MD as well as the influence of their physicochemical environment. This study aimed at investigating the influence of different operating parameters on rejection efficiency of air-gap MD towards carboxylic acids (formic, acetic and succinic acids). Acid rejection was found to be highly dependent on the carboxylic acid structure. In addition, it increased with the acid concentration, which could be related to the formation of acid dimers in the feed solution. This behavior is opposite to what is classically observed for pressure-driven membrane processes thus suggesting that MD can be a suitable alternative to these techniques for the concentration/separation of carboxylic acids. On the other hand, acid rejection decreased with the increase of feed temperature which could be explained by the calculation of the apparent energies of activation of both the water and carboxylic acids using an Arrhenius-type model. Finally, the acid dissociation rate played a key role in the acid rejection. Taking advantage of this observation, it was demonstrated how a simple pH adjustment can be used to successfully achieve the selective separation of ethanol (compared to acetic acid) from an acetic acid/ethanol aqueous mixture (typical case of the extraction of bioethanol from a fermentation broth).
Multi-Targeting of Functional Cysteines in Multiple Conserved SARS-CoV-2 Domains by Clinically Safe Zn-ejectors
Authors: Sargsyan Karen , Lin Chien-Chu , Chen Ting , Grauffel Cédric , Chen Yi-Ping , Yang Wei-Zeng , Yuan Hanna S. , Lim Carmay
Published: April 2020

We present a near-term treatment strategy to tackle pandemic outbreaks of coronaviruses with no specific drugs/vaccines by combining evolutionary and physical principles to identify conserved viral domains containing druggable Zn-sites that can be targeted by clinically safe Zn-ejecting compounds. By applying this strategy to SARS-CoV-2 polyprotein-1ab, we predicted multiple labile Zn-sites in papain-like cysteine protease (PLpro), nsp10 transcription factor, and nsp13 helicase. These are attractive drug targets because they are highly conserved among coronaviruses and play vital structural/catalytic roles in viral proteins indispensable for viral replication. We show that five Zn-ejectors can release Zn2+ from PLpro and nsp10, and clinically-safe disulfiram and ebselen can covalently bind to the Zn-bound/catalytic cysteines in both proteins. Notably, disulfiram and ebselen inhibited PLpro protease activity with IC50 in the μM range. We propose combining disulfiram/ebselen with broad-spectrum antivirals/drugs to target different conserved domains acting at various stages of the virus life cycle to synergistically inhibit SARS-CoV-2 replication and reduce the emergence of drug resistance.
Artificial, Photoinduced Activation of Nitrogenase Using Directed and Mediated Electron Transfer Processes
Authors: Meirovich Matan Moshe , Bachar Oren , Yehezkeli Omer
Published: April 2020

Nitrogenase, a bacteria-based enzyme, is the sole enzyme able to generate ammonia by atmospheric nitrogen fixation. Thus, improved understanding of its mechanism and developing methods to artificially activate it may contribute greatly to basic research, as well as to the design of future artificial systems. Here, we present methods to artificially activate nitrogenase using photoinduced reactions. Two nitrogenase variants originating from Azotobecotor vinelinii were examined using photoactivated CdS nanoparticles (NPs) capped with thioglycolic acid (TGA) or 2-mercaptoethanol (ME) ligands. The effect of methyl viologen (MV) as a redox mediator of hydrogen and ammonia generation was tested and analyzed. We further determined the NPs conductive band edges and their effect on nitrogenase photo-activation. The nano-bio hybrid systems comprising CdS NPs and nitrogenase were further imaged by transmission electron microscopy, confirming their formation for the first time. Our results show that the ME-capped CdS NPs–nitrogenase enzyme biohybrid system with added MV as redox mediator, leads to a five-fold increase in the production of ammonia compared with the non-mediated biohybrid system.
Anti-Cancer and Anti-Metastatic Activity of Cissus quadrangularis in MCF-7 Breast Cancer cell line
Authors: V S Mahendran , K Sophiya , S Sruthi Malavika , B Suganthi , P Ragul Prasath , E Sujitha
Published: April 2020

Cancer is the second leading cause of death globally. Among the group of cancer diseases, breast cancer is the most common type of cancer to affect women. The treatment options that are currently available for this include surgery, radiation therapy and therapy through medication or drugs. But, since all these are harmful and have severe side effects, drugs from natural plant compounds are being developed to act against cancer and its metastatic activity. The aim of this article is to perform in silico studies to identify phytochemicals in Cissus quadrangularis that can act against breast cancer, predict its targets and study its properties using bioinformatic tools and databases. It also involves studying of anticancer and anti-metastatic activity of the plant, Cissus quadrangularis (CQ) in MCF-7 breast cancer cell lines. CQ, a perennial plant of the grape family, has many medicinal benefits including antioxidant and anticancer properties. Alpha-amyrin, a terpenoid, was selected as a potential phytochemical in CQ and its ADME properties were studied using SwissADME. Then, its target was identified as androgen receptor using Swiss Target Prediction. Plant extract of CQ was prepared by ethyl acetate extraction method. Various tests such as MTT assay, Wound healing assay, DNA fragmentation assay, Caspase 7/9 induction detection assay and Annexin V assay were performed to evaluate the anticancer and anti-metastatic activity of CQ extract in MCF-7 cell lines. The results of the tests showed good anticancer and anti-metastasis activity of CQ with an IC50 value of 141.369µg/mL. It can be concluded that CQ has the properties required to act against breast cancer with the dose being directly proportional to the efficiency of CQ on the cancer cells.
Infecção por Cytauxzoon spp. em felinos domésticos
Authors: Ribeiro Taiã Mairon Peixoto , Santos Helcileia Dias , Reis Thássia Silva , Sousa Sebastiana Adriana Pereira , Furquim Maria Eduarda Chiaradia , André Marcos Rogério , Jayme Valéria De Sá
Published: April 2020

Cytauxzoon spp. são piroplasmas hemoparasitos que parasitam espécimes da família Felidae. A cytauxzoonose é uma enfermidade caracterizada principalmente por sinais clínicos inespecíficos e súbitos. Tem como reservatórios os felídeos silvestres, no entanto já existem relatos de parasitemia crônica em felinos domésticos. A transmissão ocorre principalmente por vetores como carrapatos na América do Norte; já na América do Sul, Europa e Ásia os vetores são ainda desconhecidos. A patogenia decorre da fase de esquizogonia do parasito em macrófagos que causa obstrução de vasos sanguíneos. O tratamento é baseado nos cuidados de suporte e a combinação terapêutica de atovaquona associada à azitromicina tem demonstrando bons resultados. A profilaxia consiste na restrição do acesso de gatos domésticos em áreas arborizadas que possuam a presença de carrapatos e no uso de repelentes-acaricidas. Com esta revisão de literatura, objetivou-se analisar os aspectos epidemiológicos, clínicos e patológicos que permitam subsidiar o médico veterinário atuar com rapidez em casos suspeitos de cytauxzoonose.
KONTRIBUSI ANTARA KOORDINASI MATA TANGAN DAN KECEPATAN REAKSI TANGAN TERHADAP PUKULAN FOREHAND DALAM PERMAINAN TENISMEJA PADA SISWA SMA NEGERI 1 MARIORIAWA KABUPATEN SOPPENG
Authors: Syamsuddin Nurliati , Hamdiana Hamdiana , Ulfa Ulfa
Published: April 2020

Penelitian ini bertujuan untuk mengetahui kontribusi koordinasi mata tangan dan kecepatan reaksi tangan terhadap pukulan forehand dalam permainan tenismeja. Penelitian ini termasuk jenis penelitian deskriptif berkorelasional. Populasi penelitian ini adalah seluruh siswa laki-laki SMA Negeri 1 Marioriawa Kabupaten Soppeng dengan jumlah sampel penelitian 40 orang yang dipilih secara random sampling. Teknik analisis data yang digunakan adalah teknik analisis korelasi dan regresi dengan menggunakan program SPSS Versi 21.00 pada taraf signifikan 95% atau a0,05. Bertolak dari hasil  analisis data, maka penelitian ini menyimpulkan bahwa: (1) Koordinasi mata tangan berkontribusi secara signifikan terhadap pukulan forehand dalam permainan tenismeja sebesar 69,1%; (2) Kecepatan reaksi tangan berkontribusi secara signifikan terhadap pukulan forehand dalam permainan tenismeja sebesar 52,8%; dan (3) Koordinasi mata tangan dan kecepatan reaksi tangan berkontribusi secara signifikan terhadap pukulan forehand dalam permainan tenismeja sebesar 69,5%
PENGARUH LATIHAN KNEE TUCK JUMP DAN LATIHAN HALF SQUAT JUMP TERHADAP KEMAMPUAN SMASH KEDENG DALAM PERMAINAN SEPAKTAKRAW
Authors: Heriansyah Heriansyah , Suhartiwi Suhartiwi
Published: April 2020

This study aims to determine the extent of the difference in effect between knee tuck jump and half squat jump training on the ability to smash kedeng in sepaktakraw games. By using the field experiment method. The population used is male students of Southeast Sulawesi SMANKO with a sample of 60 people taken by Proposive random sampling. The data analysis technique used is the t-test at 95% significance level. The results showed that; (1) There is a significant effect of knee tuck jump training on the ability to smash kedeng in sepaktakraw games on Southeast Sulawesi SMANKO students, proven to = 13,446> tt = 2,045. There is a significant effect of half squat jump training on the ability of the Kedeng smash in sepaktakraw games on Southeast Sulawesi SMANKO students, proven to = 10.478> tt = 2.045. There is a significant difference in effect between training on the ability to smash kedeng in sepaktakraw games on Southeast Sulawesi SMANKO students, proven, to = 9,970> tt = 2,000.
HUBUNGAN ANTARA DAYA LEDAK TUNGKAI, KELENTUKAN PERGELANGAN TANGAN DAN KOORDINASI MATA TANGAN TERHADAP KEMAMPUAN LAY-UP SHOOT
Authors: Nurjamal Nurjamal , Ruslan Ruslan , Ismawan Hendry
Published: April 2020

This study aims to determine the relationship between leg explosive power, wrist flexion and hand eye coordination on shoot lay-up ability. This type of research is a type of descriptive research. The research variables consisted of independent variables namely leg explosive power, wrist flexion and hand eye coordination, while the dependent variable was shoot lay-up ability. The population in this study were all students of the Health and Recreation Physical Education Study Program FKIP Mulawarman State University with a sample of 30 people. The data analysis technique used was correlation and regression analysis using the SPSS Version 22.00 system at a significance level of 95% or (α) = 0.05. Proceeding from the results of data analysis, concluded that: 1) There was a relationship between leg explosive power and lay-up shoot capability, as evidenced by the calculated r value (ro) = 0.680 (P = 0.000 <α: 0.05); 2) There is a correlation between wrist flexing and shoot lay-up ability, it is proven that the value of r count (ro) = 0.734 (P = 0.000 <α: 0.05); 3) There is a correlation between eye hand coordination and shoot lay-up ability, it is proven that the value of r count (ro) = 0.689 (P = 0.000 <α: 0.05); and 4) There is a relationship between leg explosive power, wrist flexion and hand eye coordination to the shoot lay-up ability, as evidenced by the calculated r value (ro) = 0.768 (P = 0.000 <α: 0.05).