bluuebunny/crossref_metadata_2025 huggingface dataset:
Ligand Binding and Signaling of HARE/Stabilin-2
Authors: Harris Edward N. , Cabral Fatima
Published: July 2019

The Stabilin receptors are a two-member family in the type H class of scavenger receptors. These dynamic receptors bind and internalize multiple ligands from the cell surface for the purpose of clearing extracellular material including some synthetic drugs and for sensing the external environment of the cell. Stabilin-1 was the first receptor to be cloned, though the biological activity of Hyaluronic Acid Receptor for Endocytosis (HARE)/Stabilin-2 was observed about 10 years prior to the cloning of Stabilin-1. Stabilin-1 has a more diverse expression profile among the tissues than HARE/Stabilin-2. This review will focus on HARE/Stabilin-2 and its interactions with hyaluronan, heparin, and phosphorothioate antisense oligonucleotides and what is known about how this receptor participates in signaling upon ligand binding.
RETRACTED: Ailanthone Induces Cell Cycle Arrest and Apoptosis in Melanoma B16 and A375 Cells
Authors: Liu Wenjing , Liu Xiaona , Pan Zhaohai , Wang Dan , Li Minjing , Chen Xiaoyu , Zhou Ling , Xu Maolei , Li Defang , Zheng Qiusheng
Published: July 2019

Malignant melanoma is the most lethal type of skin cancer. Previous studies have shown that ailanthone has potent antitumor activity in a variety of cell lines. However, the anti-tumor effect of ailanthone on malignant melanoma remains unclear. To investigate the anti-tumor mechanisms of ailanthone in human melanoma B16 and mouse melanoma A375 cells, the cell counting kit-8 assay, colony formation assay, DNA content analysis, Hoechst 33258, and Annexin V-FITC/PI staining were used to assess cell proliferation, cell cycle distribution, and cell apoptosis, respectively. Western blotting was performed to evaluate the expression of cell cycle- and apoptosis-related proteins and regulatory molecules. The results showed that ailanthone significantly inhibited melanoma B16 and A375 cell proliferation as well as remarkably induced cell cycle arrest at the G0–G1 phase in B16 cells and the G2–M phase in A375 cells in a dose-dependent manner. Further investigation revealed that ailanthone promoted the expression of p21 and suppressed the expression of cyclin E in B16 cells or cyclin B in A375 cells through the PI3K-Akt signaling pathway. In addition, ailanthone induced B16 and A375 cell apoptosis via a caspase-dependent mechanism. Further studies showed that ailanthone remarkably downregulated Bcl-2 and upregulated Apaf-1 and Bax, and subsequently increased mitochondrial membrane permeabilization and released cytochrome c from the mitochondria in B16 cells and A375 cells. Taken together, ailanthone induces cell cycle arrest via the PI3K-Akt signaling pathway as well as cell apoptosis via the mitochondria-mediated apoptotic signaling pathway. Ailanthone may be potentially utilized as an anti-tumor agent in the management of malignant melanoma.
Pollution-Free Approaches for Highly Efficient Sapphire Substrate Processing by Mechanical Chemical Polishing
Authors: Xu Yongchao , Lu Jing , Xu Xipeng
Published: July 2019

In this study, two pollution-free approaches were used to improve the processing efficiency of mechanical chemical polishing (MCP) for sapphire substrates. The first was dedicated to polishing using synthetic silica abrasives with high reactivity as soft abrasives, and the second was dedicated to polishing using organic acids and bases as catalysts on the polishing pad and coolant, including citric acid, theophylline, green tea, and coffee. The results showed that the rate of material removal of MCP with highly reactive silica abrasives was more than 187.5% larger than that of pristine silica abrasives with low reactivity, and surface roughness was 21% smaller than that of pristine silica abrasives. Meanwhile, in case of citric acid, the removal mass of sapphire was more that 29.2% larger than that of an original polishing method, and surface roughness was about 15.2% smaller than that of original polishing method. However, theophylline, green tea, and coffee affected processing efficiency negligibly or negatively, due to a limited effect on increasing the pH level of the coolant, and the powder residue in the coolant obstructing the contact between the nano-silica abrasive particles and sapphire surface. These results indicate that highly reactive nano-silica abrasives and citric acid show good catalytic activity towards the sapphire processing efficiency of MCP. The promoting mechanism of highly active silica abrasives and citric acid for the processing efficiency of MCP is also discussed in detail in this study.
Low Temperature Infrared Study of Carbon Monoxide Adsorption on Rh/CeO2
Authors: Idriss Hicham , Llorca Jordi
Published: July 2019

Fundamental studies of the interaction of adsorbates with metal oxides alone and on which a noble metal is deposited provide information needed for catalytic reactions. Rh/CeO2 is one of the textbook catalysts for many reactions including syngas conversion to ethanol, water gas shift reaction (WGSR), and ethanol steam reforming. In this work, the adsorption of CO is studied by infrared (IR) spectroscopy, over CeO2 and 0.6 at. % Rh/CeO2 at a temperature range of 90 to 300 K. CeO2 is in the form of nanoparticles with sizes between 5 and 10 nm and exposing predominantly {111} surface termination in addition to non-negligible fraction of the {100} termination, determined from high resolution transmission electron microscopy (HRTEM). The as prepared Rh/CeO2 contained metallic Rh as well Rh cations in higher oxidation states. At 90 K two IR bands were observed at 2183–2186 and 2161–2163 cm−1, with the former saturating first. The 2163 cm−1 peak was more sensitive to CO pressure than the 2186 cm−1. Heating resulted in the depopulation of the 2163 cm−1 before the 2186 cm−1 peak. The desorption energy computed, assuming a first-order desorption kinetic, was found to be 0.35 eV for the 2186 cm−1 and 0.30 for the 2163 cm−1 IR peak (+/−0.05 eV). The equilibrium constant at 90 K was computed equal to 1.83 and 1.33 Torr−1 for the 2183 and 2161 cm−1, respectively. CO adsorption at 90 K on Rh/CeO2 resulted (in addition to the bands on CeO2) in the appearance of a broad band in the 2110–2130 cm-1 region that contained two components at 2116 and 2126 cm−1. The high frequency of this species is most likely due to adsorption on Rh clusters with very small sizes. The desorption energy of this species was found to be equal to 0.55 eV (+/−0.05 eV). Heating the CO covered Rh/CeO2 surface accelerated the disappearance of CO species over CeO2 and resulted in the appearance of CO2 bands (at about 150 K) followed by carbonate species. At 300 K, the surface was mainly composed of carbonates.
CO2 Methanation over Ni/Al@MAl2O4 (M = Zn, Mg, or Mn) Catalysts
Authors: Le Thien An , Kim Jieun , Jeong Yu Ri , Park Eun Duck
Published: July 2019

In this study, unique core-shell aluminate spinel supports, Al@MAl2O4 (M = Zn, Mg, or Mn), were obtained by simple hydrothermal surface oxidation and were applied to the preparation of supported Ni catalysts for CO2 methanation. For comparison, CO methanation was also evaluated using the same catalysts. The prepared catalysts were characterized with a variety of techniques, including N2 physisorption, CO2 chemisorption, H2 chemisorption, temperature-programmed reduction with H2, temperature-programmed desorption of CO2, X-ray diffraction, high-resolution transmission electron microscopy, and in-situ diffuse reflectance infrared Fourier transform spectroscopy. The combination of supports with core-shell spinel structures and Ni doping with a deposition–precipitation method created outstanding catalytic performance of the Ni catalysts supported on Al@MgAl2O4 and Al@MnAl2O4 due to improved dispersion of Ni nanoparticles and creation of moderate basic sites with suitable strength. Good stability of Ni/Al@MnAl2O4 catalyst was also confirmed in the study.
Enhancing the Generated Stable Correlation in a Dissipative System of Two Coupled Qubits inside a Coherent Cavity via Their Dipole-Dipole Interplay
Authors: Mohamed Abdel-Baset , Hashem Mostafa , Eleuch Hichem
Published: July 2019

We explore the dissipative dynamics of two coupled qubits placed inside a coherent cavity-field under dipole-dipole interplay and 2-photon transitions. The generated non-classical correlations (NCCs) beyond entanglement are investigated via two measures based on the Hilbert-Schmidt norm. It is found that the robustness of the generated NCCs can be greatly enhanced by performing the intrinsic dissipation rate, dipole-dipole interplay rate, initial coherence intensity and the degree of the coherent state superpositions. The results show that the intrinsic decoherence stabilize the stationarity of the non-classical correlations while the dipole interplay rate boost them. The non-classical correlations can be frozen at their stationary correlations by increasing the intrinsic dissipation rate. Also NCCs, can be enhanced by increasing the initial coherent intensity.
Artificial Intelligence-Based Discontinuous Reception for Energy Saving in 5G Networks
Authors: Memon Mudasar Latif , Maheshwari Mukesh Kumar , Saxena Navrati , Roy Abhishek , Shin Dong Ryeol
Published: July 2019

5G is expected to deal with high data rates for different types of wireless traffic. To enable high data rates, 5G employs beam searching operation to align the best beam pairs. Beam searching operation along with high order modulation techniques in 5G, exhausts the battery power of user equipment (UE). LTE network uses discontinuous reception (DRX) with fixed sleep cycles to save UE energy. LTE-DRX in current form cannot work in 5G network, as it does not consider multiple beam communication and the length of sleep cycle is fixed. On the other hand, artificial intelligence (AI) has a tendency to learn and predict the packet arrival-time values from real wireless traffic traces. In this paper, we present AI based DRX (AI-DRX) mechanism for energy efficiency in 5G enabled devices. We propose AI-DRX algorithm for multiple beam communications, to enable dynamic short and long sleep cycles in DRX. AI-DRX saves the energy of UE while considering delay requirements of different services. We train a recurrent neural network (RNN) on two real wireless traces with minimum root mean square error (RMSE) of 5 ms for trace 1 and 6 ms for trace 2. Then, we utilize the trained RNN model in AI-DRX algorithm to make dynamic short or long sleep cycles. As compared to LTE-DRX, AI-DRX achieves 69 % higher energy efficiency on trace 1 and 55 % more energy efficiency on trace 2, respectively. The AI-DRX attains 70 % improvement in energy efficiency for trace 2 compared with Poisson packet arrival model for λ = 1 / 20 .
Analysis of Counting Bloom Filters Used for Count Thresholding
Authors: Kim Kibeom , Jeong Yongjo , Lee Youngjoo , Lee Sunggu
Published: July 2019

A bloom filter is an extremely useful tool applicable to various fields of electronics and computers; it enables highly efficient search of extremely large data sets with no false negatives but a possibly small number of false positives. A counting bloom filter is a variant of a bloom filter that is typically used to permit deletions as well as additions of elements to a target data set. However, it is also sometimes useful to use a counting bloom filter as an approximate counting mechanism that can be used, for example, to determine when a specific web page has been referenced more than a specific number of times or when a memory address is a “hot” address. This paper derives, for the first time, highly accurate approximate false positive probabilities and optimal numbers of hash functions for counting bloom filters used in count thresholding applications. The analysis is confirmed by comparisons to existing theoretical results, which show an error, with respect to exact analysis, of less than 0.48% for typical parameter values.
The Impacts of Water Pricing and Non-Pricing Policies on Sustainable Water Resources Management: A Case of Ghorveh Plain at Kurdistan Province, Iran
Authors: Asaadi Mohammad Ali , Mortazavi Seyed Abolghasem , Zamani Omid , Najafi Gholam Hassan , Yusaf Talal , Hoseini Seyed Salar
Published: July 2019

As with other regions of Iran, due to excessive extraction of groundwater for intense agricultural activity, Ghorveh plain, a water-scarce irrigation district in the west of Iran, has faced a serious water crisis during the last decade. The present study investigates the impacts of two scenario policies, namely, non-price policy (as a supply-oriented policy) and water pricing policies (as a demand-oriented policy) on agricultural sector of Ghorveh Plain, using positive mathematical programming (PMP). The model was calibrated by using farm-level data for the crop years in 2016–2017. Our findings indicate that applying water supply constraint policy will change the land use and cropping pattern to the crops with higher water productivity. The increase of water resource constraints can lead to the increase of water economic return which indicates a rising value of water resources shortage, warning the producers of the agriculture sector to allocate water to the crops with higher economic value under the water resources shortage conditions. In addition, the findings underline that in a situation where the price of irrigation water is low due to the low elasticity of water demand in the agriculture sector, formulating the economic instruments such as rising water prices does not solely suffice to achieve sustainable water resource management. However, mixed scenarios emphasized that the water distribution policies should be aligned with the increases in water cost.
Cornu Spirals and the Triangular Lacunary Trigonometric System
Authors: Vogt Trenton , Ulness Darin J.
Published: July 2019

This work is intended to directly supplement the previous work by Coutsias and Kazarinoff on the foundational understanding of lacunary trigonometric systems and their relation to the Fresnel integrals, specifically the Cornu spirals [Physica 26D (1987) 295]. These systems are intimately related to incomplete Gaussian summations. The current work provides a focused look at the specific system built off of the triangular numbers. The special cyclic character of the triangular numbers modulo m carries through to triangular lacunary trigonometric systems. Specifically, this work characterizes the families of Cornu spirals arising from triangular lacunary trigonometric systems. Special features such as self-similarity, isometry, and symmetry are presented and discussed.
Anisotropy of Magnetic Susceptibility and Preferred Pore Orientation in Lava Flow from the Ijen Volcanic Complex, East Java, Indonesia
Authors: Atarita Fadhli Ramadhana , Bijaksana Satria , Ndari Nuresi Rantri Desi Wulan , Pratama Aditya , Taqwantara Reyhan Fariz , Fajar Silvia Jannatul , Latief Fourier Dzar Eljabbar
Published: July 2019

Anisotropy of magnetic susceptibility (AMS) has been used in various studies related to interpreting the direction of lava flow, some of which have shown ambiguity with regard to the data generated. In this study, we explored an alternative option to support the aforementioned application, using lava flow type igneous rock samples from the Ijen Volcanic Complex, East Java, Indonesia. We have investigated the preferred rock pore orientations from micro-computed tomography (μCT) images and quantified their directions. We then calculated their correlation with AMS data by calculating the angle between preferred pore orientation. The axis with the smallest gap to the preferred pore orientation of each sample was assumed to imply lava flow direction. Different lava flow direction preferences were obtained from different magnetic ellipsoids. Another important factor for consideration is the relative vertical position of the sampling site within a single lava flow unit. Only one out of five samples (ANY2) show good quantitative conformity between AMS data, preferred pore orientation, and topographical slope, despite these limitations. Our results point to a direction that seems to be correct and coherent on a physical basis. Additional research would likely clarify the issues involved. This encourages us to explore and work further in this field of research.
Hydrochemical Analysis of Groundwater in Remah and Al Khatim Regions, United Arab Emirates
Authors: Khan Qasim , Kalbus Edda , Alshamsi Dalal M. , Mohamed Mohamed M. , Liaqat Muhammad U.
Published: July 2019

Groundwater constitutes an important part of the available water resources in arid areas. Knowledge of the quantitative and qualitative status of groundwater is a key aspect in optimal groundwater management. The purpose of this study was to provide technical information on the groundwater in the sand aquifer of two neighboring areas in the United Arab Emirates to support stakeholders working towards sustainable groundwater development. The chemical characteristics of the groundwater have been used to identify the processes controlling groundwater chemistry and assess the suitability of the groundwater for agricultural purposes. Despite tapping into the same aquifer, considerable differences in groundwater quality were found between the two study areas. The area with a shallower water table showed clear indications of irrigation return flow deteriorating the groundwater quality. Using standard agricultural indices, the groundwater at both study areas is classified as unfit for agricultural purposes. However, considering that groundwater is the only available water source for irrigation, it will continue to be used for agriculture. This indicates the need for improved irrigation management and the development of new strategies for sustainable groundwater development in arid areas in the context of food security.
Relationships between Parental Socialization Styles, Empathy and Connectedness with Nature: Their Implications in Environmentalism
Authors: Musitu-Ferrer Daniel , León-Moreno Celeste , Callejas-Jerónimo Juan Evaristo , Esteban-Ibáñez Macarena , Musitu-Ochoa Gonzalo
Published: July 2019

Parents exert a strong influence on several adjustment outcomes. However, little is known about their influence on adolescents’ connectedness with the environment. This study examined the relationships between parenting styles, empathy and connectedness with the environment. The two-dimensional socialization model was used with four resulting styles: Indulgent, authoritative, neglectful and authoritarian. The sample comprised 797 adolescents (52.7% girls) from six public secondary schools who were aged between 12 and 16 years (M = 13.94, SD = 1.28). The results showed significant relationships between parental socialization styles, empathy and connectedness with nature. It was also observed that adolescents from indulgent and authoritative families showed higher levels of empathy and connectedness with the environment than adolescents raised by authoritarian and neglectful parents, with males from such families consistently presenting the lowest levels of empathy and connectedness, which was not the case among women. Additionally, women, regardless of the parental style in which they had been educated, showed greater cognitive and emotional empathy with the natural environment, while adolescents raised in indulgent and authoritative families displayed higher levels of empathy and connectedness than those with authoritarian and neglectful parents. These results suggest that indulgent and authoritative styles are stronger enablers of empathy and connectedness with nature.
The Effects of Imitation Dynamics on Vaccination Behaviours in SIR-Network Model
Authors: Chang Sheryl Le , Piraveenan Mahendra , Prokopenko Mikhail
Published: July 2019

We present a series of SIR-network models, extended with a game-theoretic treatment of imitation dynamics which result from regular population mobility across residential and work areas and the ensuing interactions. Each considered SIR-network model captures a class of vaccination behaviours influenced by epidemic characteristics, interaction topology, and imitation dynamics. Our focus is the resultant vaccination coverage, produced under voluntary vaccination schemes, in response to these varying factors. Using the next generation matrix method, we analytically derive and compare expressions for the basic reproduction number R 0 for the proposed SIR-network models. Furthermore, we simulate the epidemic dynamics over time for the considered models, and show that if individuals are sufficiently responsive towards the changes in the disease prevalence, then the more expansive travelling patterns encourage convergence to the endemic, mixed equilibria. On the contrary, if individuals are insensitive to changes in the disease prevalence, we find that they tend to remain unvaccinated. Our results concur with earlier studies in showing that residents from highly connected residential areas are more likely to get vaccinated. We also show that the existence of the individuals committed to receiving vaccination reduces R 0 and delays the disease prevalence, and thus is essential to containing epidemics.
On the Use of Mobile Devices as Controllers for First-Person Navigation in Public Installations
Authors: Vosinakis Spyros , Gardeli Anna
Published: July 2019

User navigation in public installations displaying 3D content is mostly supported by mid-air interactions using motion sensors, such as Microsoft Kinect. On the other hand, smartphones have been used as external controllers of large-screen installations or game environments, and they may also be effective in supporting 3D navigations. This paper aims to examine whether a smartphone-based control is a reliable alternative to mid-air interaction for four degrees of freedom (4-DOF) fist-person navigation, and to discover suitable interaction techniques for a smartphone controller. For this purpose, we setup two studies: A comparative study between smartphone-based and Kinect-based navigation, and a gesture elicitation study to collect user preferences and intentions regarding 3D navigation methods using a smartphone. The results of the first study were encouraging, as users with smartphone input performed at least as good as with Kinect and most of them preferred it as a means of control, whilst the second study produced a number of noteworthy results regarding proposed user gestures and their stance towards using a mobile phone for 3D navigation.
Novel Approaches for Fracture Detection in Steel Girder Bridges
Authors: Abedin Mohammad , Mehrabi Armin B.
Published: July 2019

The bottom flanges of steel plate girder bridges can be considered fracture-critical elements depending on the number of girders and bridge configuration. For such cases, it is required that inspection of these bridges be carried out using costly “arms-length” approach. New techniques in structural health monitoring (SHM) that use non-contact sensors and self-powered wireless sensors present alternative approach for inspection. Application of such techniques would allow timely detection and application of repair and strengthening, in other word, providing for more resilient bridges. This paper investigates the feasibility of using a handful of self-powered wireless or non-contact sensors for continuous or periodic monitoring and detection of fracture in steel plate girder bridges. To validate this concept, vibration measurements were performed on an actual bridge in the field, and detailed finite element analyses were carried out on a multi-girder bridge. The records obtained show that vibration amplitude was significantly increased for fractured girder, and a distinct pattern of strain variation was registered in the vicinity of fracture, all of which can be detected effectively with relevant sensors. Moreover, the amplitude and frequency of the vibration was shown to be significant enough for providing the required power for typical sensor(s).
Efficacy of the Small Step Program in a Randomized Controlled Trial for Infants under 12 Months Old at Risk of Cerebral Palsy (CP) and Other Neurological Disorders
Authors: Holmström Linda , Eliasson Ann-Christin , Almeida Rita , Furmark Catarina , Weiland Ann-Louise , Tedroff Kristina , Löwing Kristina
Published: July 2019

The objective was to evaluate the effects of the Small Step Program on general development in children at risk of cerebral palsy (CP) or other neurodevelopmental disorders. A randomized controlled trial compared Small Step with Standard Care in infants recruited at 4–9 months of corrected age (CA). The 35-week intervention targeted mobility, hand use, and communication during distinct periods. The Peabody Developmental Motor Scales2ed (PDMS-2) was the primary outcome measure. For statistical analysis, a general linear model used PDMS-2 as the main outcome variable, together with a set of independent variables. Thirty-nine infants were randomized to Small Step (n = 19, age 6.3 months CA (1.62 SD)) or Standard Care (n = 20, age 6.7 months CA (1.96 SD)). Administering PDMS-2 at end of treatment identified no group effect, but an interaction between group and PDMS-2 at baseline was found (p < 0.02). Development was associated with baseline assessments in the Standard Care group, while infants in the Small Step group developed independent of the baseline level, implying that Small Step helped the most affected children to catch up by the end of treatment. This result was sustained at 2 years of age for PDMS-2 and the PEDI mobility scale.
Sustainable, Fluorine-Free, Low Cost and Easily Processable Materials for Hydrophobic Coatings on Flexible Plastic Substrates
Authors: Prontera Carmela T. , Sico Giuliano , Montanino Maria , De Girolamo Del Mauro Anna , Tassini Paolo , Maglione Maria G. , Minarini Carla , Manini Paola
Published: July 2019

Zinc oxide nanoparticles (ZnONPs) and stearic acid are herein used for the preparation of hydrophobic coatings with good moisture barrier property on flexible plastic substrates. Fast, high throughput, mild and easy-to-run processing techniques, like airbrushing and gravure printing, are applied for thin films deposition of these materials. The results of this study indicated that the best hydrophobic coating in terms of water contact angle (115°) is obtained through a two-steps printing deposition of a ZnONPs layer followed by a stearic acid layer. All the deposition procedures proved to be effective in terms of water vapor barrier properties, reaching values of 0.89 g/m2/day, with a 45% reduction with respect to the bare substrate. These preliminary data are very encouraging in the perspective of a low cost and green approach for the realization of functional coatings for packaging applications.
Corrosion Resistance to Chloride of a Novel Stainless Steel: The Threshold Chloride Value and Effect of Surface State
Authors: Wang Hailong , Wu Yuanjian , Sun Xiaoyan , Ling Jiayan , Zou Daoqin
Published: July 2019

To evaluate the corrosion resistance of a novel stainless steel intended for use within reinforced concrete (RC) structures exposed to aggressive environments, the threshold chloride concentration of three stainless steels (316, 2205, novel 2205) and two carbon steels (HRB400, HRB500) exposed to pore solutions of fresh concrete was experimentally studied by means of electrochemical methods. The effect of steel surface state on the corrosion resistance was also experimentally investigated. The results showed that the novel stainless steel has a much higher corrosion resistance than those of the carbon steels and stainless steels when subjected to chloride environments. The presence of surface damage leads to significant decrease of corrosion resistance for carbon steel, however the corrosion can be certainly inhibited with the accumulation of rust on the steel surface. Although the oxide layer was worn, the novel 2205 stainless steel still has a great corrosion resistance.
Thermal Stability and Flammability Behavior of Poly(3-hydroxybutyrate) (PHB) Based Composites
Authors: Vahabi Henri , Michely Laurent , Moradkhani Ghane , Akbari Vahideh , Cochez Marianne , Vagner Christelle , Renard Estelle , Saeb Mohammad Reza , Langlois Valérie
Published: July 2019

A series of samples based on poly(3-hydroxybutyrate) (PHB) containing five different additives were prepared and their thermal stability and flammability were discussed. The samples first underwent flammability screening by using Pyrolysis Combustion Flow Calorimeter (PCFC) analyses. Then, four samples were selected for further investigations. PHB composites containing sepiolite (Sep.) inorganic nanofiller, and also organic ammonium polyphosphate (APP) were examined for flammability and thermal behavior using PCFC, thermogravimetric analysis (TGA), flame test, and Differential Scanning Calorimetry (DSC) analyses. Moreover, burning behavior of samples were captured on a digital camera to give a deeper sense of their flammability character for comparison. The results revealed a significant improvement of flammability and thermal stability of composites, particularly in the presence of sepiolite with respect to the value obtained for unfilled PHB. Regarding TGA results, the char residue yield was increased to ca. 20.0 wt.% in the presence of sepiolite, while 0.0 wt.% was observed for PHB. PCFC measurements uncovered higher performance of PHB-Sep. sample as signaled by 40% reduction in the peak of heat release rate with respect to PHB. According to observations, PHB-Sep. sample showed non-dripping behavior with high capacity of charring in the presence of Sep. in a vertical flame test.
Precipitation Kinetics and Evaluation of the Interfacial Mobility of Precipitates in an AlSi7Cu3.5Mg0.15 Cast Alloy with Zr and V Additions
Authors: Heugue Pierre , Larouche Daniel , Breton Francis , Massinon Denis , Martinez Rémi , Chen X.-Grant
Published: July 2019

Recent environmental restrictions constrained car manufacturers to promote cast aluminum alloys working at high temperatures (180 °C–300 °C). The development of new alloys permits the fabrication of higher-strength components in engine downsizing. Those technologies increase internal loadings and specific power and stretch current materials to their limits. Transition metals in aluminum alloys are good candidates to improve physical, mechanical, and thermodynamic properties with the aim of increasing service life of parts. This study is focused on the modified AlSi7Cu3.5Mg0.15 alloy where Mn, Zr, and V have been added as alloying elements for high-temperature applications. The characterization of the cast alloy in this study helps to evaluate and understand its performance according to their physical state: As-cast, as-quenched, or artificially aged. The precipitation kinetics of the AlSi7Cu3.5Mg0.15 (Mn, Zr, V) alloy has been characterized by differential scanning calorimetry (DSC), transmission electron microscopy (TEM) observations, and micro-hardness testing. The Kissinger analysis was applied to extract activation energies from non-isothermal DSC runs conducted at different stationary heating rates. Finally, first-order evaluations of the interfacial mobility of precipitates were obtained.
Experimental Modeling of Silicate and Carbonate Sulfidation under Lithospheric Mantle P,T-Parameters
Authors: Zdrokov Evgeniy , Novoselov Ivan , Bataleva Yuliya , Borzdov Yuri , Palyanov Yuri
Published: July 2019

Interactions of mantle silicates with subducted carbonates, sulfides, and sulfur-rich fluids are experimentally simulated in the olivine-ankerite-sulfur and olivine-ankerite-pyrite systems using a multi-anvil high-pressure split-sphere apparatus at 6.3 GPa and range of 1050–1550 °C. Recrystallization of Fe,Ni-bearing olivine and ankerite in a sulfur melt was found to be accompanied by sulfidation of olivine and carbonate, involving partial extraction of metals, carbon, and oxygen into the melt, followed by the formation of pyrite (±pyrrhotite), diopside, and Fe-free carbonates. The main features of metasomatic alteration of Fe,Ni-olivine by a reduced sulfur fluid include: (i) a zonal structure of crystals (Fe-rich core, Mg-rich rim); (ii) inclusions of pyrite and pyrrhotite in olivine; (iii) certain Raman spectral characteristics of olivine. At T > 1350 °C, two immiscible melts, a predominantly sulfur melt with dissolved components (or a Fe–Ni–S–O melt) and a predominantly carbonate one, are generated. The redox interaction of these melts leads to the formation of metastable graphite (1350–1550 °C) and diamond growth (1550 °C). The studied olivine-ankerite-sulfur and olivine-ankerite-pyrite interactions may be considered as the basis for simulation of metasomatic processes accompanied by the formation of mantle sulfides during subduction of crustal material to the silicate mantle.
Influence of Bacterial Physiology on Processing of Selenite, Biogenesis of Nanomaterials and Their Thermodynamic Stability
Authors: Piacenza Elena , Presentato Alessandro , Bardelli Marta , Lampis Silvia , Vallini Giovanni , Turner Raymond J.
Published: July 2019

We explored how Ochrobactrum sp. MPV1 can convert up to 2.5 mM selenite within 120 h, surviving the challenge posed by high oxyanion concentrations. The data show that thiol-based biotic chemical reaction(s) occur upon bacterial exposure to low selenite concentrations, whereas enzymatic systems account for oxyanion removal when 2 mM oxyanion is exceeded. The selenite bioprocessing produces selenium nanomaterials, whose size and morphology depend on the bacterial physiology. Selenium nanoparticles were always produced by MPV1 cells, featuring an average diameter ranging between 90 and 140 nm, which we conclude constitutes the thermodynamic stability range for these nanostructures. Alternatively, selenium nanorods were observed for bacterial cells exposed to high selenite concentration or under controlled metabolism. Biogenic nanomaterials were enclosed by an organic material in part composed of amphiphilic biomolecules, which could form nanosized structures independently. Bacterial physiology influences the surface charge characterizing the organic material, suggesting its diverse biomolecular composition and its involvement in the tuning of the nanomaterial morphology. Finally, the organic material is in thermodynamic equilibrium with nanomaterials and responsible for their electrosteric stabilization, as changes in the temperature slightly influence the stability of biogenic compared to chemogenic nanomaterials.
Zn(II) Curcuminate Complexes with 2,2′-bipyridine and Carboxylates
Authors: Grabner Sabina , Modec Barbara
Published: July 2019

Two novel zinc(II) compounds with curcuminate (abbreviated as cur−), [Zn(CH3COO)(cur)(bpy)](1)·CH3OH·2H2O (bpy = 2,2′-bipyridine) and [Zn(PhCOO)(cur)(bpy)] (2)·CH3OH, have been synthesized and characterized. Their composition has been determined by single-crystal X-ray structure analysis. Complexes 1 and 2 are similar: in both a five-fold coordination environment of zinc(II) consists of a monodentate carboxylate, a chelating bidentate 2,2′-bipyridine, and curcuminate, which is bound via a deprotonated 1,3-dione moiety. In 1, 2,2′-bipyridine nitrogen atoms and curcuminate oxygen atoms form the base of a square pyramid, whereas the acetate oxygen occupies its apex. The O3N2 donor set in 2 defines a polyhedron which more closely resembles a trigonal bipyramid. The packing in the crystal lattices of both compounds is governed by hydrogen-bonds. Complexes 1 and 2 display higher stability than curcumin in buffered media at pH = 7.0, however, the degradation of coordinated cur− is comparable to that of yellow pigment curcumin (curH) when the pH is raised to 7.2. Both complexes 1 and 2 in DMSO exhibit fluorescence with Stokes shifts of 5367 and 4634 cm−1, respectively.
Formation of ZnO/Zn0.5Cd0.5Se Alloy Quantum Dots in the Presence of High Oleylamine Contents
Authors: Chen Yi-An , Chou Kuo-Hsien , Kuo Yi-Yang , Wu Cheng-Ye , Hsiao Po-Wen , Chen Po-Wei , Yuan Shuo-Huang , Wuu Dong-Sing
Published: July 2019

To the best of our knowledge, this report presents, for the first time, the schematic of the possible chemical reaction for a one-pot synthesis of Zn0.5Cd0.5Se alloy quantum dots (QDs) in the presence of low/high oleylamine (OLA) contents. For high OLA contents, high-resolution transmission electron microscopy (HRTEM) results showed that the average size of Zn0.5Cd0.5Se increases significantly from 4 to 9 nm with an increasing OLA content from 4 to 10 mL. First, [Zn(OAc)2]–OLA complex can be formed by a reaction between Zn(OAc)2 and OLA. Then, Fourier transform infrared (FTIR) spectroscopy and X-ray diffraction (XRD) data confirmed that ZnO is formed by thermal decomposition of the [Zn(OAc)2]–OLA complex. The results indicated that ZnO grew on the Zn0.5Cd0.5Se surface, thus increasing the particle size. For low OLA contents, HRTEM images were used to estimate the average sizes of the Zn0.5Cd0.5Se alloy QDs, which were approximately 8, 6, and 4 nm with OLA loadings of 0, 2, and 4 mL, respectively. We found that Zn(OAc)2 and OLA could form a [Zn(OAc)2]–OLA complex, which inhibited the growth of the Zn0.5Cd0.5Se alloy QDs, due to the decreasing reaction between Zn(oleic acid)2 and Se2−, which led to a decrease in particle size.
Fabrication of Troponin I Biosensor Composed of Multi-Functional DNA Structure/Au Nanocrystal Using Electrochemical and Localized Surface Plasmon Resonance Dual-Detection Method
Authors: Lee Taek , Kim Jinmyeong , Nam Inho , Lee Yeonju , Kim Ha Eun , Sohn Hiesang , Kim Seong-Eun , Yoon Jinho , Seo Sang Woo , Lee Min-Ho , Park Chulhwan
Published: July 2019

In the present study, we fabricated a dual-mode cardiac troponin I (cTnI) biosensor comprised of multi-functional DNA (MF-DNA) on Au nanocrystal (AuNC) using an electrochemical method (EC) and a localized surface plasmon resonance (LSPR) method. To construct a cTnI bioprobe, a DNA 3 way-junction (3WJ) was prepared to introduce multi-functionality. Each DNA 3WJ arm was modified to possess a recognition region (Troponin I detection aptamer), an EC-LSPR signal generation region (methylene blue: MB), and an anchoring region (Thiol group), respectively. After an annealing step, the multi-functional DNA 3WJ was assembled, and its configuration was confirmed by Native-TBM PAGE for subsequent use in biosensor construction. cTnI was also expressed and purified for use in biosensor experiments. To construct an EC-LSPR dual-mode biosensor, AuNCs were prepared on an indium-tin-oxide (ITO) substrate using an electrodeposition method. The prepared multi-functional (MF)-DNA was then immobilized onto AuNCs by covalent bonding. Field emission scanning electron microscope (FE-SEM) and atomic force microscopy (AFM) were used to analyze the surface morphology. LSPR and electrochemical impedance spectroscopy (EIS) experiments were performed to confirm the binding between the target and the bioprobe. The results indicated that cTnI could be effectively detected in the buffer solution and in diluted-human serum. Based on the results of these experiments, the loss on drying (LOD) was determined to be 1.0 pM in HEPES solution and 1.0 pM in 10% diluted human serum. Additionally, the selectivity assay was successfully tested using a number of different proteins. Taken together, the results of our study indicate that the proposed dual-mode biosensor is applicable for use in field-ready cTnI diagnosis systems for emergency situations.
Chemistry Routes for Copolymer Synthesis Containing PEG for Targeting, Imaging, and Drug Delivery Purposes
Authors: Rahme Kamil , Dagher Nazih
Published: July 2019

Polyethylene glycol (PEG) is one of the most frequently used polymers for coating nanocarriers to enhance their biocompatibility, hydrophilicity, stability, and biodegradability. PEG is now considered to be among the best biocompatible polymers. It offers sterical hindrance against other nanoparticles and blood components such as opsonin, preventing their macrophage phagocytosis and resulting in a prolonged circulation time in blood stream, consequently a ‘stealth character’ in vivo. Therefore, PEG has a very promising future for the development of current therapeutics and biomedical applications. Moreover, the vast number of molecules that PEG can conjugate with might enhance its ability to have an optimistic perspective for the future. This review will present an update on the chemistry used in the modern conjugation methods for a variety of PEG conjugates, such methods include, but are not limited to, the synthesis of targeting PEG conjugates (i.e., Peptides, Folate, Biotin, Mannose etc.), imaging PEG conjugates (i.e., Coumarin, Near Infrared dyes etc.) and delivery PEG conjugates (i.e., doxorubicin, paclitaxel, and other hydrophobic low molecular weight drugs). Furthermore, the type of nanoparticles carrying those conjugates, along with their biomedical uses, will be briefly discussed.
Distributed Model Predictive Control of Steam/Water Loop in Large Scale Ships
Authors: Zhao Shiquan , Maxim Anca , Liu Sheng , De Keyser Robin , Ionescu Clara
Published: July 2019

In modern steam power plants, the ever-increasing complexity requires great reliability and flexibility of the control system. Hence, in this paper, the feasibility of a distributed model predictive control (DiMPC) strategy with an extended prediction self-adaptive control (EPSAC) framework is studied, in which the multiple controllers allow each sub-loop to have its own requirement flexibility. Meanwhile, the model predictive control can guarantee a good performance for the system with constraints. The performance is compared against a decentralized model predictive control (DeMPC) and a centralized model predictive control (CMPC). In order to improve the computing speed, a multiple objective model predictive control (MOMPC) is proposed. For the stability of the control system, the convergence of the DiMPC is discussed. Simulation tests are performed on the five different sub-loops of steam/water loop. The results indicate that the DiMPC may achieve similar performance as CMPC while outperforming the DeMPC method.
Effects of Back Touching on Tidal Volume
Authors: Hitomi Taichi , Yachi Chigusa Theresa , Yamaguchi Hajime
Published: July 2019

The purpose of this basic experiment was to examine the effects of soft touching on an experiment participant’s back on tidal volume (TV), as an increase in TV was considered an indication of enhanced relaxation. Healthy experiment participants were divided into an intervention group, where soft touching was administered for two minutes on their back, and a control group, where they were asked to rest. Then the change in TV was measured using a spiro-meter two factor analysis of variance (ANOVA; mixture design) was conducted. As a result of two factor ANOVA, the intervention group’s TV changed with statistical significance, while no statistically significant change was observed in the control group. There was a possibility that soft touching on the back had a positive effect on the increase of TV and relaxation. As a result of soft touching on the back, TV was increased. Subjective indicators suggested that the relaxation was enhanced by soft touching on the back.
An Improved Time-Series Model Considering Rheological Parameters for Surface Deformation Monitoring of Soft Clay Subgrade
Authors: Xing Xuemin , Chen Lifu , Yuan Zhihui , Shi Zhenning
Published: July 2019

Building deformation models consistent with reality is a crucial step for time-series deformation monitoring. Most deformation models are empirical mathematical models, lacking consideration of the physical mechanisms of observed objects. In this study, we propose an improved time-series deformation model considering rheological parameters (viscosity and elasticity) based on the Kelvin model. The functional relationships between the rheological parameters and deformation along the Synthetic Aperture Radar ( SAR) line of sight are constructed, and a method for rheological parameter estimation is provided. To assess the feasibility and accuracy of the presented model, both simulated and real deformation data over a stretch of the Lungui highway (built on soft clay subgrade in Guangdong province, China) are investigated with TerraSAR-X satellite imagery. With the proposed deformation model, the unknown rheological parameters over all the high coherence points are obtained and the deformation time-series are generated. The high-pass (HP) deformation component and external leveling ground measurements are utilized to assess the modeling accuracy. The results show that the root mean square of the residual deformation is ±1.6 mm, whereas that of the ground leveling measurements is ±5.0 mm, indicating an improvement in the proposed model by 53%, and 34% compared to the pure linear velocity model. The results indicate the reliability of the presented model for the application of deformation monitoring of soft clay highways. The estimated rheological parameters can be provided as a reference index for the interpretation of long-term highway deformation and the stability control of subgrade construction engineering.
Exercise-Induced Mitohormesis for the Maintenance of Skeletal Muscle and Healthspan Extension
Authors: Musci Robert , Hamilton Karyn , Linden Melissa
Published: July 2019

Oxidative damage is one mechanism linking aging with chronic diseases including the progressive loss of skeletal muscle mass and function called sarcopenia. Thus, mitigating oxidative damage is a potential avenue to prevent or delay the onset of chronic disease and/or extend healthspan. Mitochondrial hormesis (mitohormesis) occurs when acute exposure to stress stimulates adaptive mitochondrial responses that improve mitochondrial function and resistance to stress. For example, an acute oxidative stress via mitochondrial superoxide production stimulates the activation of endogenous antioxidant gene transcription regulated by the redox sensitive transcription factor Nrf2, resulting in an adaptive hormetic response. In addition, acute stresses such as aerobic exercise stimulate the expansion of skeletal muscle mitochondria (i.e., mitochondrial biogenesis), constituting a mitohormetic response that protects from sarcopenia through a variety of mechanisms. This review summarized the effects of age-related declines in mitochondrial and redox homeostasis on skeletal muscle protein homeostasis and highlights the mitohormetic mechanisms by which aerobic exercise mitigates these age-related declines and maintains function. We discussed the potential efficacy of targeting the Nrf2 signaling pathway, which partially mediates adaptation to aerobic exercise, to restore mitochondrial and skeletal muscle function. Finally, we highlight knowledge gaps related to improving redox signaling and make recommendations for future research.
Burnout and Perceived Performance Among Junior Athletes—Associations with Affective and Cognitive Components of Stress
Authors: Moen Frode , Hrozanova Maria , Stiles Tore C. , Stenseng Frode
Published: July 2019

The current study investigated associations between cognitive components such as psychological resilience and perceived stress, and affective components such as positive and negative affect, and athlete burnout and perceived performance among 670 Norwegian junior athletes attending high schools specialized for sports. A hypothesized model of the relations between the constructs was analyzed by structural equation modeling (SEM). The results in the current study show that athlete resilience is a key in understanding athlete burnout and perceived performance, and that cognitive (perceived stress) and affective reactions (negative and positive affect) are important mediators in this process.