Herpesvirus infections in the formation of acute and chronic pathology: rationale for timely therapy
Authors:   G.N.Gabrichevsky Research Institute of Epidemiology and Microbiology, Moscow, Russian Federation, Ruzhentsova T.A. ,   Moscow Medical University "Reaviz", Moscow, Russian Federation, Garbuzov A.A. ,   G.N.Gabrichevsky Research Institute of Epidemiology and Microbiology, Moscow, Russian Federation, Kanibolotskiy A.A. ,   Sklifosovsky Research Institute for Emergency Medicine, Moscow, Russian Federation, Borisova O.Yu. ,   G.N.Gabrichevsky Research Institute of Epidemiology and Microbiology, Moscow, Russian Federation, Voropaeva E.A. ,   G.N.Gabrichevsky Research Institute of Epidemiology and Microbiology, Moscow, Russian Federation, Shushakova E.K. ,   City Medical Research Center, Moscow, Russian Federation, Khavkina D.A. ,   G.N.Gabrichevsky Research Institute of Epidemiology and Microbiology, Moscow, Russian Federation, Chukhlyaev P.V. ,   G.N.Gabrichevsky Research Institute of Epidemiology and Microbiology, Moscow, Russian Federation, Khalyastov I.N. ,   Moscow Medical University "Reaviz", Moscow, Russian Federation, Orlova V.A. ,   Mechnikov Research Institute of Vaccines and Sera, Moscow, Russian Federation, Mikhailova I.I. ,   Mechnikov Research Institute of Vaccines and Sera, Moscow, Russian Federation, Kalyuzhnaya N.O. ,   Mechnikov Research Institute of Vaccines and Sera, Moscow, Russian Federation, Meshkova N.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Slyusar O.I. ,   Moscow Medical University "Reaviz", Moscow, Russian Federation
Published: March 2024

Objective. To determine the frequency and possible clinical significance of herpesvirus DNA detection in various organs. Materials and methods. The study included 168 samples of the cerebral cortex, myocardium, vascular walls, liver, kidneys, and lungs from 28 deceased people. The causes of death were cardiopulmonary insufficiency due to decompensation of atherosclerosis (15 (54%) patients, study group) or intoxication due to septic conditions (13 (46%) patients, comparison group). DNA viruses were detected using the polymerase chain reaction. Results. The most frequently detected virus was human herpes virus type 6 (HHV-6) (82%), less frequently – Epstein-Barr virus (58%), cytomegalovirus and herpes simplex virus type 1 (17% each). In the study group, HHV-6 DNA was more often found in the myocardium (87%), cerebral cortex (47%) and liver (40%). Conclusion. In 87% of cases of death from decompensation of atherosclerotic changes, HHV-6 DNA was found in altered areas of the myocardium. In the brain, liver, kidneys and lungs, HHV-6 was detected less frequently. The association of the presence of HHV-6 DNA with the severity of changes in the heart, brain, liver and kidneys and the presence of other herpesviruses with symptoms of acute respiratory viral infection require the prescription of an antiviral agent with a broad spectrum of action. Inosine pranobex is indicated to prevent the progression of somatic pathology by stopping the activity of herpesvirus infection, which often accompanies or is the main factor in the symptoms of acute respiratory viral infection. Key words: HHV-6, atherosclerosis, human herpes virus type 6, herpes, herpesvirus infection, ARVI, PCR, inosine pranobex