bluuebunny/crossref_metadata_2025 huggingface dataset:
Dens Invaginatus and the Paediatric Dental Patient: Two Case Reports
Authors: O'Dowling Keane Shane , Lucey Siobhán , Quilligan Graham
Published: January 2023

##Background

Dens Invaginatus (DI) in paediatric patients presents a challenge in treatment planning, patient management and potentially complex endodontic treatment. DI has been reported to be as prevalent as 0.3% to 10% in permanent teeth. Clinicians may be challenged in managing both the patient and the dental anomaly.

##Aims

The aim of these case reports is to highlight the presenting features of DI, treatment strategies and to highlight the need for a national clinical care pathway for children affected by dental anomalies such as DI, in addition to complex traumatic dental injuries and developmental defects of enamel and dentine.

##Conclusions

Awareness of the clinical features and early identification of teeth affected by DI can allow for prevention, minimally invasive management, and where necessary, appropriate referral for specialist management of these cases. Sealing the palatal surfaces of young permanent incisors can limit the sequelae of pulpal necrosis in teeth with DI. Teeth with DI and complex anatomical presentation are predisposed to pulpal pathology and restorative management can be extremely challenging. Currently there are limited referral options for General Dental Practitioners who identify cases of DI in primary care settings in Ireland. This may lead to delayed treatment, prolonged symptoms and suboptimal outcomes for patients. A national clinical care pathway is recommended.
Apreciaciones léxico-semánticas en torno a un inventario aragonés de 1658
Authors: Ortiz Cruz Demelsa
Published: January 2023

En este trabajo se analizan los aspectos léxicos más significativos de un inventario aragonés de 1658. Dicho inventario posee un indudable valor, no solo por tratarse de un corpus inédito, sino también por contener voces o acepciones que interesan desde un punto de vista dialectal (como barrastra o caza, por ejemplo), así como sentidos o palabras escasamente documentadas (como [taza] campanilla o embutidor, entre otras).
Gómez de Enterría, Josefa (2020): El vocabulario de la medicina en el español del siglo XVIII, Berna, Peter Lang, 589 pp. ISBN: 978-3-0343-3772-4
Authors: Molina Sangüesa Itziar
Published: January 2023

Reseña de la obra: Gómez de Enterría, Josefa (2020): El vocabulario de la medicina en el español del siglo XVIII, Berna, Peter Lang, 589 pp. ISBN: 978-3-0343-3772-4.
Burnout, estrés y autoestima sobre el rendimiento académico en universitarios del área de la salud
Authors: Torres-Zapata Ángel Esteban , Torres-Zapata Angela , Acuña-Lara Juana Patricia , Moguel-Ceballos Juan Eduardo , Brito-Cruz Teresa del Jesús
Published: January 2023

A las instituciones educativas les resulta útil medir el rendimiento académico de los estudiantes para saber el alcance de los objetivos educativos, sin embargo, este puede estar afectado por diversos factores, como el burnout académico, estrés académico y baja autoestima del estudiante. El presente trabajo plantea como objetivo, describir el estado actual del conocimiento sobre el efecto del burnout académico, estrés académico o autoestima deteriorada, sobre el rendimiento académico en estudiantes de pregrado del área de la salud; los resultados permitirán generar estrategias de intervención desde la acción tutorial. Los estudiantes universitarios del área de la salud, deben poseer un adecuado bienestar, incluyendo el aspecto mental, ya que estos individuos precisan brindar servicio a la comunidad; algunas de las características en estas licenciaturas son la seguridad y confianza en sí mismo para tomar decisiones, por esta razón, es fundamental apuntalar en la detección oportuna del estrés, burnout y desarrollo de la autoestima en los estudiantes para evitar en la medida de lo posible la depresión, ansiedad, angustia y adicciones, de lo contrario, los alumnos no podrán sostener la carga académica y profesional o hacer frente de manera adecuada a los obstáculos que se presenten en el camino médico asistencial.

Palabras clave:

Burnout, estrés, autoestima, rendimiento académico.

 

ABSTRACT

Educational institutions find it useful to measure the academic performance of students to know the scope of educational objectives, however, this may be affected by various factors, such as academic burnout, academic stress and low student self-esteem. The objective of this work is to describe the current state of knowledge on the effect of academic burnout, academic stress or impaired self-esteem, on academic performance in undergraduate students in the health area; The results will allow generating intervention strategies from the tutorial action. University students in the area of ​​health must have adequate well-being, including the mental aspect, since these individuals need to provide service to the community; Some of the characteristics in these degrees are security and self-confidence to make decisions, for this reason, it is essential to support the timely detection of stress, burnout and development of self-esteem in students to avoid as far as possible depression, anxiety, anguish and addictions, otherwise, students will not be able to sustain the academic and professional load or adequately face the obstacles that arise in the medical care path.

Keywords:

Burnout, stress, self-esteem, academic performance.
Programa de acondicionamiento físico para la mejorar la fuerza en mujeres de 30 a 39 años en Ciudad del Carmen, México
Authors: Zaleta-Morales Lorena , Ruíz-Campos Verónica B. , Blanco-del Valle Aarón
Published: January 2023

En la investigación se elabora un programa de acondicionamiento físico mediante el cual se desarrollan las capacidades físicas para una mejora de la calidad de vida en mujeres de 30 a 39 años para ayudar a fortalecer sus capacidades condicionales en especial: la fuerza y la resistencia. Este programa se desarrolló en un periodo de tres meses, siendo un tipo de estudio cuantitativo, descriptivo y preexperimental, con una población de 20 mujeres entre 30 y 39 años de Ciudad del Carmen, Campeche a quienes se les realizó una prueba previa, el programa de intervención y se aplicó un post-test para la recolección y análisis de datos. Todo lo anterior bajo el consentimiento de los participantes.

Palabras clave:

Actividad física, fuerza, resistencia, sistema de ejercicios, mujeres y entrenamiento.

 

ABSTRACT

In the investigation, a physical conditioning program is developed through which the physical capacities are developed to improve the quality of life in women from 30 to 39 years of age to help strengthen their conditional capacities, especially: strength and resistance. This program will be developed in a period of three months, being a type of quantitative, descriptive and pre-experimental study, with a population of 20 women between 30 and 39 years of age from Ciudad del Carmen, Campeche who underwent a previous test, the program intervention and a post-test was applied for data collection and analysis. All of the above under the consent of the participants.

Keywords:

Physical activity, strength, endurance, exercise system, women and training.
Editorial
Authors: Pino Sera PhD. Yamilka
Published: January 2023

Enero es el primer mes del año y con él se inicia un número más de la revista Excelencia Educativa (EXCED), encaminada a la sostenibilidad de la ciencia y fin de dar solución a las principales demandas académicas y científicas de los diferentes profesionales que nos asisten. La sociedad, y con ellas las diferentes instituciones que la integran potencian la ciencia de la sostenibilidad, mediante el empleo de nuevas técnicas, métodos científicos, la aplicación herramientas matemáticas, para con ello lograr satisfacer las necesidades sociales, materiales y espirituales.

Las ciencias sociales, como constructo humano, tienen una determinada sostenibilidad y finalidad, ofrecer soluciones a temáticas como las presentada en el presente número de la revista, tales como: “Efectos de las bacterias RR72, RR79 RC138 en el crecimiento de Cucumis sativus L en casa de cultivos protegidos”, o la incorporación de nuevas tecnologías como el: “Diseño del sistema automatizado para la generación y gestión de documentos en la etapa precontractual de compras públicas para instituciones públicas en el Ecuador” y la implementación de un “Programa de acondicionamiento físico para mejorar la fuerza en mujeres de 30 a 39 años en Ciudad del Carmen, México”.

En tal sentido, la revista enriquece la Ciencia de la Sostenibilidad, como una forma más de modificar las ciencias y la sociedad, por lo que les recomendamos leer “Las tecnologías de la información y la comunicación en la práctica docente con alumnos universitarios de nuevo ingreso durante COVID-19”, con una interesante novedad acerca del uso de la tecnología para la aprensión de determinados conceptos “El Proceso de enseñanza-aprendizaje de los conceptos de la matemática superior en las carreras de Ingeniería”; también sobre problemáticas que aquejan a determinados profesionales como el “Burnout, estrés y autoestima sobre el rendimiento académico en universitarios del área de la salud” y por último le sugerimos consultar el “Papel del abogado en la defensa del principio constitucional de presunción de inocencia en Cuba”. Esta interdisciplinariedad enriquece la publicación y comparte saberes científicos y culturales.
For the Record
Authors: Stroshane Eric
Published: January 2023

NationwideAlabamaArizonaFloridaGeorgiaIowaMississippiOklahomaSouth DakotaTennesseeTexasUtahVirginiaManhattan Beach, CaliforniaOrange County, CaliforniaGreeley, ColoradoProvidence, Rhode IslandCampbell County, VirginiaMclean, Virginia
Censorship Dateline
Authors: Stroshane Eric
Published: January 2023

SchoolsPrisons
Small towns of Latvia: disparities in regional and urban development
Authors: Voronov Viktor V.
Published: January 2023

The article reports on the results of an economic and sociological study conducted by the Institute of Sociology of the Russian Academy of Sciences in collaboration with Daugavpils University (Latvia) in 2020—2021. The study aimed to identify the reasons for the disparity in the development of small towns in Latvia. A comprehensive approach was taken to integrate the results of territorial, spatial and socio-economic analyses. By employing the methodology of indexing and ranking large-scale empirical data characterising the development of all small towns in Latvia, the authors attempt to identify the reasons for the disparity in the development rate of small towns in Latvia. The index of territorial development of regions, cities and rural settlements was developed and has been tested by the State Agency for Regional Development of Latvia since 2013. The data collected were then analysed taking into account the geographical location of small towns. The research showed that the main factors influencing the development of small towns are the level of business activity and the role of local authorities in the provision of public funding. The article describes prospects for the polycentric development of small towns and analyses the ways of reducing disparities in their development in terms of the working and living conditions of their residents.
Cost-Effectiveness Analysis of 177Lu-PSMA-617 Radioligand Therapy in Metastatic Castration-Resistant Prostate Cancer
Authors: Mehrens Dirk , Kramer Kristina K.M. , Unterrainer Lena M. , Beyer Leonie , Bartenstein Peter , Froelich Matthias F. , Tollens Fabian , Ricke Jens , Rübenthaler Johannes , Schmidt-Hegemann Nina-Sophie , Herlemann Annika , Unterrainer Marcus , Kunz Wolfgang G.
Published: January 2023

Background: Metastatic castration-resistant prostate cancer poses a therapeutic challenge with poor prognosis. The VISION trial showed prolonged progression-free and overall survival in patients treated with lutetium Lu 177 vipivotide tetraxetan (177Lu-PSMA-617) radioligand therapy compared with using the standard of care (SoC) alone. The objective of this study was to determine the cost-effectiveness of 177Lu-PSMA-617 treatment compared with SoC therapy. Methods: A partitioned survival model was developed using data from the VISION trial, which included overall and progression-free survival and treatment regimens for 177Lu-PSMA-617 and SoC. Treatment costs, utilities for health states, and adverse events were derived from public databases and the literature. Because 177Lu-PSMA-617 was only recently approved, costs for treatment were extrapolated from 177Lu-DOTATATE. Outcome measurements included the incremental cost, effectiveness, and cost-effectiveness ratio. The analysis was performed in a US setting from a healthcare system perspective over the lifetime horizon of 60 months. The willingness-to-pay threshold was set to $50,000, $100,000, and $200,000 per quality-adjusted life years (QALYs). Results: The 177Lu-PSMA-617 group was estimated to gain 0.42 incremental QALYs. Treatment using 177Lu-PSMA-617 led to an increase in costs compared with SoC ($169,110 vs $85,398). The incremental cost, effectiveness, and cost-effectiveness ratio for 177Lu-PSMA-617 therapy was $200,708/QALYs. Sensitivity analysis showed robustness of the model regarding various parameters, which remained cost-effective at all lower and upper parameter bounds. In probabilistic sensitivity analysis using Monte Carlo simulation with 10,000 iterations, therapy using 177Lu-PSMA-617 was determined as the cost-effective strategy in 37.14% of all iterations at a willingness-to-pay threshold of $200,000/QALYs. Conclusions: Treatment using 177Lu-PSMA-617 was estimated to add a notable clinical benefit over SoC alone. Based on the model results, radioligand therapy represents a treatment strategy for patients with metastatic castration-resistant prostate cancer with cost-effectiveness in certain scenarios.
A Survey of the National Comprehensive Cancer Network on Approaches Toward Addressing Patients’ Transportation Insecurity
Authors: Chaiyachati Krisda H. , Krause Diana , Sugalski Jessica , Graboyes Evan M. , Shulman Lawrence N.
Published: January 2023

Background: Addressing patients’ social determinants of health is a national priority for cancer treatment centers. Transportation insecurity is one major challenge for patients undergoing active cancer treatment, and missing treatments can result in worse cancer treatment outcomes, including worse morbidity and mortality. How cancer treatment centers are addressing transportation insecurity is understudied. Methods: In January and February 2022, the NCCN Best Practices Committee conducted a survey of NCCN’s 31 Member Institutions (currently 32 member institutions as of April 2022) to assess how centers were addressing patient transportation insecurity: how they screen for transportation insecurity, coordinate transportation, and fund transportation initiatives, and their plans to address transportation insecurity in the future. Results: A total of 25 of 31 (81%) NCCN Member Institutions responded to the survey, of which 24 (96%) reported supporting the transportation needs of their patients through screening, coordinating, and/or funding transportation. Patients’ transportation needs were most often identified by social workers (96%), clinicians (83%), or patients self-declaring their needs (79%). Few centers (33%) used routine screening approaches (eg, universal screening of social risk factors) to systematically identify transportation needs, and 54% used the support of technology platforms or a vendor to coordinate transportation. Transportation was predominantly funded via some combination of philanthropy (88%), grants (63%), internal dollars (63%), and reimbursement from insurance companies (58%). Over the next 12 months, many centers were either going to continue their current transportation programs in their current state (60%) or expand existing programs (32%). Conclusions: Many NCCN Member Institutions are addressing the transportation needs of their patients. Current efforts are heterogeneous. Few centers have systematic, routine screening approaches, and funding relies on philanthropy more so than institutional dollars or reimbursement from insurers. Opportunities exist to establish more structured, scalable, and sustainable programs for patients’ transportation needs.
Thriving in Ambiguity – A Dispositive of Self-Optimisation
Authors: Heinrich Grit Claudia
Published: January 2023

This paper explores a discrepancy between research and application in the operationalisation of ambiguity tolerance. Observational results from the practice of human resource development raised the question: How does the umbrella term ambiguity tolerance relate to the Frenkel-Brunswik theorem, and has this possibly become a dispositive of self-optimisation? Methodologically, the article follows a literature-based approach. Tracing three shifts in the reception of the term, the trend around tolerance of ambiguity is linked to its theoretical construct. While by no means exhaustive, by recontextualising the Frenkel-Brunswik theorem in this way and bringing it into focus, the article aims to open up further discussion.
Logical Positivism or Critical Theory as the Methodological Foundation of The Authoritarian Personality?
Authors: Schmidt Peter
Published: January 2023

In this paper, the central research question discusses to what extent logical positivism or critical theory forms the methodological core of the seminal work on the authoritarian personality. A central thesis is that due to her background in psychology, logical positivism and psychoanalysis and her neglected but central role in the authoritarian personality study, Else Frenkel-Brunswik has had a much more lasting and productive influence on authoritarianism research than Adorno as the rep­resentative of critical theory. This was certainly not reflected in the public discourse or in intellectual discussions, at least in Europe. This article shows how the original F-Scale was changed in subse­quent research and how the application of psychometric techniques improved. However, by employ­ing Lakatos’ concept of the research programme, I analyse how authoritarianism research developed in a degenerative way by reducing the number of factors from nine to three and giving up the psy­choanalytic explanation of the underlying mechanisms, a systematic test of sociological and contex­tual factors, and the original mixed method approach of combining surveys and qualitative inter­views. Finally, the issue of the effects of idealisation of parents on the measurement of the items and the use of typologies were not tackled in later research. Employing data from the German General Social Survey (ALLBUS), I describe how some of Frenkel-Brunswik’s central methodological and theoretical ideas have been tested using confirmatory factor analyses and structural equation mod­els. Finally I summarise the way in which the research programme can be developed more fruitfully by integrating developmental psychology, sociology, political science, psychoanalysis and statistical generalised latent variable models.
Allowing for Ambiguity in the Social Sciences
Authors: Kranebitter Andreas , Gruber Fabian
Published: January 2023

This paper gives a micro-sociological view on the methodology used by Else Frenkel-Brunswik in the famous study The Authoritarian Personality (Adorno et al. 1950). A thorough reconstruction of the theoretical and methodological concepts of Else Frenkel-Brunswik eventually allows for a full appreciation of her works from a today’s social research perspective, especially of her role in the field of authoritarianism-research. The paper deals with (i) Else Frenkel-Brunswik’s role in the research team of The Authoritarian Personality, (ii) the way she followed up on her earlier work, (iii) the question of in which ways her parts of the study were object of criticism by the numerous critics of TAP, and (iv) the ways she herself responded to these critics. The material basis for such an approach is the archival material available in the “Archive for the History of Sociology in Austria (AGSO)” in Graz, Austria, which holds parts of the estate of Else Frenkel-Brunswik, most of all her correspondence and unpublished typoscripts of later publications, as well as at the Institute for Jewish Research (YIVO) in New York, which holds the papers of the American Jewish Committee, i.e., draft reports, memoranda, and some interview protocols of the TAP study.
Else Frenkel Brunswik and Contemporary Sociologists
Authors: Fleck Christian
Published: January 2023

The article presents and discusses an unpublished critical remark written by Robert K Merton which addressed Else Frenkel Brunswik's contribution to The Authoritarian Personality. The author contextualizes both Merton’s remarks and the book’s reception by other contemporary sociologists.
Helping Hands
Authors: Fleck Christian
Published: January 2023

Book Review of:
Leff, Laurel (2019) Well Worth Saving: American Universities’ Life-and-Death Decisions onRefugees from Nazi Europe. New Haven; London: Yale University Press357 pp.ISBN 978-0-300-24387-1Price: $30.00
Mulder, Bertus (2021) Sophie Louisa Kwaak und das Kapital der Unternehmerfamilie Weil: EinBeitrag zur Wirtschaftsgeschichte der Frankfurter Schule [Sophie Louisa Kwaak and the capitalof the entrepreneurial family Weil: A contribution to the economic history of the Frankfurt School].Translated from Dutch by Arne Braun. Göttingen: Wallstein Verlag283 pp.ISBN 978-38353-3915-6Price: €24.90
Stöckel, Tommy (2020) Wissenschaftsorganisatoren in den Sozialwissenschaften 1890–1940[Managers of the social sciences 1890–1940]. Wiesbaden: Springer Fachmedien (HumboldtUniversity Berlin Dissertation)575 pp.ISBN 978-3-658-38168-4Price: €64.99
The Language of Ecopoetry and the Transfer of Meaning
Authors: O'Loughlin Cassandra J.
Published: January 2023

This article explores the properties of ecopoetry that have to do with the realisation that we are not merely external observers but active and intrinsic participants within the biosphere. The type of ecopoetics I am advocating takes a subjective stance to experience: it begins from within individual consciousness and is rooted in sensory perception. Reference to the world through this type of ecopoetry evokes a tone or mood, or “atmosphere” between environmental attributes and human experience that can solicit an emotional response. Ecopoetry can deliver meaning on a level beyond the direct connotations of the signs and symbols on the page. This has to do with “presence” as a phenomenological approach to the aesthetics of nature. Employing these concepts has the potential to bridge the gap between nature and politics, and influence attitudes towards living sustainably with the earth.
Ecofeminist Poetry as Living on Earth with Attention and Care
Authors: Vincent Esther Xueming
Published: January 2023

The article explores ecofeminism as intersectional, founded upon a politics of relations. Through an ecofeminist re-reading of Eavan Boland’s “Anna Liffey” and Grace Nichols’ “Hurricane Hits England”, the article discusses how these women poets remake geographies to locate themselves in time and place as kin to other person-beings.
The Manfred Max-Neef Thinking: A Deep Economy Rooted in the Eco-philosophical Perspective of the Deep Ecology
Authors: Olmedo Clara , Ceberio de León Iñaki
Published: January 2023

In this article, we advance preliminary theoretical reflections on Manfred Max Neef’s thoughts related to the human scale development. From an and transdisciplinary perspective, we argue that Max-Neef moves beyond the field of Ecological Economics towards developing a Deep Economic framework, linked to the Deep Ecology framework outlined by the Norwegian philosopher Arne Næss. We elaborate our argument around two dimensions: a) Biocentrism, based on the conviction that ecology is not limited to reflections and actions toward a balanced and healthy environment to achieve humans´ well-being, but involves all forms of life and ecosystems. b) The intrinsic value of life, a complex idea that Max-Neef expressed in his conviction that the “reverence for life” cannot be solely subjected to human economic activity or interest. Biocentrism and the intrinsic value of life must be approached from a transdisciplinary and organic perspective that demands a dialogue between science-academics, non-combining reason with intuition, ethics, and beauty. this way, these two dimensions become principles that articulate Max-Neef´s Deep Economy, different to other critical approaches in the field of economics.
Two Poems
Authors: Kalyanasundaram Srisrividhiya
Published: January 2023

How do we open our sense of being? What is to be our intrinsic nature - iyalbu from which action flows freely bound by the laws of a chosen, crafted consciousness? What is this residual loneliness of being that makes us who we are as part of the greater earth? How do we create a sense of belonging? How do we find ourselves - trillions of years old in star dust and tracing our ways back to a single ancestor of life?
La imagen apostrófica. Un ensayo de iconomitología
Authors: Fernández-Jáuregui Rojas Carlota
Published: January 2023

Este artículo toma como punto de partida dos imágenes separadas por más de veinte siglos que describen un mismo gesto. Su lectura comparada permite esbozar una definición de “imagen apostrófica” y desplegar las relaciones entre palabra e imagen que existen tanto en el mito como en el retrato. Para ello, se relatan los orígenes del gesto obsceno que liga ambas imágenes, en una lectura de la historia mítica formada por Deméter y Baubo. En estas versiones, el gesto adquiere una doble dimensión verbal y visual que lleva a comprender la escena de Yambe/Baubo como un iconomito que sirve de paradigma en una reflexión mayor sobre la “imagen apostrófica”, formulada desde la retórica y la teoría temática de la gramática.
Conversando con W.J.T. Mitchell, «Más imágenes que nunca»
Authors: Martínez Luna Sergio
Published: January 2023

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El acto icónico
Authors: Bredekamp Horst
Published: January 2023

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Laocoonte. Número 9
Authors: Completo Número
Published: January 2023

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Staff Retention in the IT Pandemic Context
Authors: Iulia Szabo Brigitta , Balaci Mariana
Published: January 2023

This study focuses on IT employee retention, particularly during the COVID-19 pandemic. Retaining and employing young IT professionals today is a challenging task for human resources employees. We believe that this is a topical and very relevant topic for the HR field as most companies are facing staff turnover, especially after the COVID-19 pandemic. It is also known that the IT sector is very dynamic and constantly evolving, companies need manpower and competitiveness among employers is high. In addition, a poor retention strategy can have a negative effect on the productivity and work quality of the IT department. And these are some good reasons for a company to invest in a retention strategy. Our research is qualitative in nature and we have sought to identify aspects of employee motivation and satisfaction with the benefits they receive from their employers. Understanding the real needs of IT employees was also one of the aims of this research. The results of the investigation indicated a strong relevance of retention means such as the salary, the team and the good relationship with colleagues, the working environment and the development opportunities available to employees within the company.
Faktor - Faktor yang Berhubungan dengan Kematian Pasien COVID-19 Lansia di Ruang Rawat Inap RSUD Kabupaten Karanganyar
Authors: Hidayati Soraya , Adnan Nurhayati
Published: January 2023

Virus COVID-19 terus menyebabkan lebih banyak orang menjadi sakit dan meninggal dunia setiap harinya. Selain itu, varian virus COVID-19 baru juga terus ditemukan. Lebih dari 80% kematian karena COVID-19 terjadi pada penderita yang memiliki komorbid dan berusia di atas 65 tahun. Perlu diketahui penyakit komorbid apa saja yang berpengaruh terhadap kematian pasien COVID-19 lansia. Tujuan penelitian ini adalah untuk mengetahui faktor-faktor yang dapat meningkatkan risiko kematian COVID-19 pada pasien lansia yang melakukan rawat inap di RSUD Karanganyar mulai Januari 2020 - Mei 2021. Sebanyak 322 pasien COVID-19 lansia yang terdata dalam file database rekam medis pasien rawat inap di RSUD Kabupaten Karanganyar digunakan dalam penelitian kuantitatif ini dengan menggunakan desain cross sectional. Analisis data dilakukan dengan menggunakan regresi logistik untuk menguji hubungan jenis kelamin, TBC paru, diabetes mellitus, ginjal kronis, stroke, dan jantung dengan kematian pasien COVID-19 lansia. Dari total sampel yang diteliti, sebanyak 18,9% diantaranya meninggal dunia. Pasien COVID-19 lansia perempuan yang meninggal dunia adalah sebanyak 54,1%. Dari total 61 pasien COVID-19 lansia yang meninggal, penyakit komorbid yang paling banyak diderita adalah DM (21,3%), hipertensi (16,4%), stroke (11,5%), ginjal kronis (8,2%), jantung (8,2%), dan TBC paru (3,3%).  Hasil analisis multivariat menunjukkan bahwa hanya riwayat hipertensi yang secara statistik terkait dengan peningkatan risiko kematian pada pasien COVID-19 lansia (OR= 2,647; 95% CI: 1,154 – 6,070), sedangkan variabel yang lainnya tidak berhubungan. Pasien lansia dengan komorbid tersebut perlu diprioritaskan untuk diberikan penanganan medis secara optimal karena lebih rentan terhadap kematian.
Beban Penyakit dan Program Pencegahan dan Pengendalian Penyakit Tidak Menular di Indonesia
Authors: Wahidin Mugi , Agustiya Rozana Ika , Putro Gurendro
Published: January 2023

Penyakit tidak menular (PTM) menjadi masalah kesehatan utama di Indonesia. Program pencegahan dan pengendalian PTM hendaknya sesuai dengan beban PTM di masyarakat. Penelitian bertujuan menganalisis beban penyakit (burden of disease/BoD) dan program pencegahan dan pengendalian PTM di Indonesia. Penelitian ini merupakan penelitian mixed methods (kuantitatif dan kualitatif) yang dilaksanakan di DKI Jakarta, Jambi, dan DI Yogyakarta pada Juli – Desember 2019. Desain studi yang digunakan pada penelitian kuantitatif adalah descriptive cross-sectional. Variabel yang dikaji adalah beban PTM, program pencegahan dan pengendalian PTM, dan gap antara program PTM dan beban PTM. Beban PTM menggunakan data sekunder hasil studi BoD 2017. Program dan gap PTM menggunakan data primer yang digali dari informan yang berasal dari Kementerian Kesehatan, organisasi profesi, lembaga swadaya masyarakat, dan dinas kesehatan provinsi. Pedoman wawancara dan panduan round table discussion (RTD) digunakan untuk mengumpulkan data primer. Data sekunder dianalisis secara deskriptif kuantitatif dan data primer dianalisis kualitatif dengan content analysis. Triangulasi data menggunakan triangulasi metode yaitu wawancara mendalam dan RTD. Hasil kajian menujukkan beban PTM sangat tinggi yaitu 70% dari seluruh beban penyakit, faktor risiko utama PTM adalah tekanan darah tinggi, diet, gula darah tinggi, obesitas, dan merokok. Program promosi, pencegahan, dan deteksi dini PTM kurang optimal. Data BoD dapat dimanfaatakan di tingkat nasional maupun provinsi. Terdapat gap antara program dengan beban PTM. Solusi yang ditawarkan yaitu peningkatan promosi kesehatan melalui teknologi informasi, peningkatan deteksi dini, pengendalian faktor risiko terutama diet dan rokok.
Analisis Kematian Coronavirus Diseases 2019 (COVID-19) dengan Standardisasi Usia Berdasarkan Wilayah di Indonesia periode Maret 2020 – Mei 2021
Authors: Aqmarina Adistikah , Adnan Nurhayati , Hastuti Endang Budi
Published: January 2023

Coronavirus Disease 2019 (COVID-19) merupakan jenis penyakit menular baru yang sampai saat ini masih ditetapkan sebagai pandemi. Berbagai studi menyebutkan risiko kematian COVID-19 lebih tinggi pada kelompok lanjut usia terutama dengan riwayat penyakit penyerta. Ketersediaan rumah sakit dan laboratorium pemeriksa COVID-19 yang tidak adekuat juga dapat memberikan pengaruh terhadap tingginya angka kematian COVID-19. Studi ini bertujuan untuk membandingkan tingkat kematian COVID-19 di wilayah Indonesia dengan mengontrol variabel usia serta didukung dengan analisis ketersediaan rumah sakit dan laboratorium pemeriksa COVID-19. Penelitian ini menggunakan desain studi potong lintang (cross sectional) dengan data sekunder laporan COVID-19 nasional di Kementerian Kesehatan periode Maret 2020 – Mei 2021. Analisis dilakukan dengan metode standardisasi langsung terhadap variabel usia sehingga dihasilkan nilai Age Standardized Mortality Rate (ASMR). Hasil penelitian menunjukkan bahwa kematian COVID-19 di Indonesia tertinggi yaitu pada kelompok lanjut usia (>65 tahun). Setelah dilakukan standardidasi, pulau Jawa (3,82 per 100 kasus) dan pulau Sumatera (3,76 per 100 kasus) menjadi wilayah dengan rate kematian tertinggi. Berdasarkan provinsi, rate kematian tertinggi yaitu provinsi Sumatera Selatan (6,14 per 100 kasus), Jawa Timur (5,93 per 100 kasus) dan Aceh (5,59 per 100 kasus). Ketersediaan rumah sakit berbanding terbalik dengan jumlah kematian COVID-19 yang dilaporkan. Sedangkan, ketersediaan laboratorium pemeriksa COVID-19 berbanding linier dengan jumlah kasus konfirmasi COVID-19 yang dilaporkan. Ketersediaan rumah sakit dan laboratorium pemeriksa COVID-19 harus didukung dengan sarana penunjang operasional. Penelitian ini menjadi penting terutama bagi pemerintah baik pusat maupun daerah untuk menentukan prioritas kelompok intervensi serta mendukung upaya percepatan penanggulangan pandemi COVID-19.
Faktor-faktor yang Berhubungan dengan Kejadian Stroke pada Penduduk Usia ≥15 Tahun di Provinsi Daerah Istimewa Yogyakarta (Analisis Data Riskesdas 2018)
Authors: Azzahra Vika , Ronoatmodjo Sudarto
Published: January 2023

Menurut Riset Kesehatan Dasar (Riskesdas) 2013, prevalensi stroke pada penduduk usia ≥ 15 tahun di Indonesia sebesar 7 permil dan mengalami kenaikan dari tahun 2007 yang sebesar 6 permil. Provinsi Daerah Istimewa Yogyakarta (DIY) menjadi provinsi dengan prevalensi stroke tertinggi kedua di Indonesia dan prevalensinya melebihi angka nasional yakni sebesar 10,3 permil pada tahun 2013. Tujuan studi ini untuk mengetahui faktor-faktor yang berhubungan dengan kejadian stroke pada penduduk usia ≥15 tahun di Provinsi DIY. Penelitian ini menggunakan desain cross-sectional, dengan menganalisis data Riskesdas 2018 Provinsi DIY sebanyak 6695 responden. Chi square dan regresi logistik ganda digunakan sebagai uji statistik pada penelitian ini. Hasil penenlitian menyatakan prevalensi stroke pada penduduk usia ≥ 15 tahun di Provinsi DIY tahun 2018 sebesar 1,7%. Faktor yang memiliki hubungan statistik signifikan dengan kejadian stroke antara lain usia (POR=3,23; 95% CI=2,03-5,13), aktivitas fisik (POR=2,86; 95% CI=1,90-4,31), hipertensi (POR=5,69; 95% CI=3,68-8,79), penyakit jantung (POR=2,57; 95% CI=1,47-4,48), dan diabetes melitus (POR=2,44; 95% CI=1,49-3,40). Dari penelitian ini, disimpulkan bahwa ada hubungan antara usia, aktivitas fisik, hipertensi, penyakit jantung, dan diabetes melitus dengan kejadian stroke pada penduduk usia ≥ 15 tahun di Provinsi DIY.
Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single-cell resolution
Authors: Ainciburu Marina , Ezponda Teresa , Berastegui Nerea , Alfonso-Pierola Ana , Vilas-Zornoza Amaia , San Martin-Uriz Patxi , Alignani Diego , Lamo-Espinosa Jose , San-Julian Mikel , Jiménez-Solas Tamara , Lopez Felix , Muntion Sandra , Sanchez-Guijo Fermin , Molero Antonieta , Montoro Julia , Serrano Guillermo , Diaz-Mazkiaran Aintzane , Lasaga Miren , Gomez-Cabrero David , Diez-Campelo Maria , Valcarcel David , Hernaez Mikel , Romero Juan P , Prosper Felipe
Published: January 2023

Early hematopoiesis is a continuous process in which hematopoietic stem and progenitor cells (HSPCs) gradually differentiate toward specific lineages. Aging and myeloid malignant transformation are characterized by changes in the composition and regulation of HSPCs. In this study, we used single-cell RNA sequencing (scRNA-seq) to characterize an enriched population of human HSPCs obtained from young and elderly healthy individuals.

Based on their transcriptional profile, we identified changes in the proportions of progenitor compartments during aging, and differences in their functionality, as evidenced by gene set enrichment analysis. Trajectory inference revealed that altered gene expression dynamics accompanied cell differentiation, which could explain aging-associated changes in hematopoiesis. Next, we focused on key regulators of transcription by constructing gene regulatory networks (GRNs) and detected regulons that were specifically active in elderly individuals. Using previous findings in healthy cells as a reference, we analyzed scRNA-seq data obtained from patients with myelodysplastic syndrome (MDS) and detected specific alterations of the expression dynamics of genes involved in erythroid differentiation in all patients with MDS such as TRIB2. In addition, the comparison between transcriptional programs and GRNs regulating normal HSPCs and MDS HSPCs allowed identification of regulons that were specifically active in MDS cases such as SMAD1, HOXA6, POU2F2, and RUNX1 suggesting a role of these transcription factors (TFs) in the pathogenesis of the disease.

In summary, we demonstrate that the combination of single-cell technologies with computational analysis tools enable the study of a variety of cellular mechanisms involved in complex biological systems such as early hematopoiesis and can be used to dissect perturbed differentiation trajectories associated with perturbations such as aging and malignant transformation. Furthermore, the identification of abnormal regulatory mechanisms associated with myeloid malignancies could be exploited for personalized therapeutic approaches in individual patients.
MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size
Authors: Lafferty Michael J , Aygün Nil , Patel Niyanta K , Krupa Oleh , Liang Dan , Wolter Justin M , Geschwind Daniel H , de la Torre-Ubieta Luis , Stein Jason L
Published: January 2023

Expression quantitative trait loci (eQTL) data have proven important for linking non-coding loci to protein-coding genes. But eQTL studies rarely measure microRNAs (miRNAs), small non-coding RNAs known to play a role in human brain development and neurogenesis. Here, we performed small-RNA sequencing across 212 mid-gestation human neocortical tissue samples, measured 907 expressed miRNAs, discovering 111 of which were novel, and identified 85 local-miRNA-eQTLs. Colocalization of miRNA-eQTLs with GWAS summary statistics yielded one robust colocalization of miR-4707–3p expression with educational attainment and brain size phenotypes, where the miRNA expression increasing allele was associated with decreased brain size. Exogenous expression of miR-4707–3p in primary human neural progenitor cells decreased expression of predicted targets and increased cell proliferation, indicating miR-4707–3p modulates progenitor gene regulation and cell fate decisions. Integrating miRNA-eQTLs with existing GWAS yielded evidence of a miRNA that may influence human brain size and function via modulation of neocortical brain development.
Effectiveness of Ten Weeks Community-Based Multicomponent Exercise Program on Physiological Health of Elderly Women
Authors: Bandyopadhyay Nita , Das Tuhin
Published: January 2023

Background: The advancement of technology and medical science has prolonged the longevity of humans, compelling each individual to deal with old age. New health issues are cropping up, especially since lifestyle has become sedentary. Regular physical exercises are the only option for healthy aging. Purpose: The study observed the effect of 10 weeks planned community-based multicomponent exercise program (CBMCEP) on selected physiological variables of elderly women in the Indian sub-urban area. Methodology: A quasi-experimental investigation was carried out in 2019 with 30 sedentary women volunteer of 55-65 years from the middle socio-economic class who were purposively assigned into experimental group (n=15) and control group (n=15). The experimental group was given 10 weeks- 4 days/week of CBMCEP in a progressive manner that included brisk walking, resistance exercise, balance, flexibility exercise and recreational activities of 80-90 minutes duration. The control group was not exposed to such a program. Pre and post-test were conducted on physiological variables like Resting Heart Rate (RHR), Resting blood pressure (Systolic- SDP; Diastolic- DBP), Postprandial Blood Sugar level (BSpp), and Haemoglobin concentration (Hb) by the registered medical practitioner. The obtained data were statistically analyzed by independent t-test for baseline differences between the groups and paired sample t-test to obtain the CBMCEP effect on dependent variables. Result: Statistical analysis revealed 10 weeks of CBMCEP can significantly reduce the RHR (p=0.003), SBP (p=0.039), DBP (p=0.052), BSpp level (p=0.015), and Hb concentration (p=0.009). Conclusion: The CBMCEP can promote significant improvement in the physiological health of elderly women. Further, it was noted that fitness experts may implement such cost-effective CBMCEP to ensure the healthy aging of a nation.
Relationship Between Variability in Clubhead Movement Using a Doppler Radar Launch Monitor and Golf Strokes Across 15 Driver Shots
Authors: Ichikawa Daisuke , Suzuki Takeru , Patrick Sheahan John , Miyazawad Taiki , Okuda Isao
Published: January 2023

Background: Due to individual patterns of body and clubhead movement in golf, a uniform assessment method has been considered difficult. Objective: This study aimed to establish a statistical model that can assess a player’s shot performance in a short time by analyzing the relationship between the golf strokes and their clubhead movement data. Methods: In this cross-sectional, observational study, we analyzed the clubhead movement data of 15 driver shots (three sets of five shots) by 14 amateur golfers (AGs) and 14 skilled golfers (SGs). After performing warm-up, participants used their own drivers to hit at a crosshair-shaped target positioned in an indoor driving range. Data were captured for each parameter relating to clubhead movement at the moment of impact using the Doppler radar launch monitor (FlightScope X3). Results: Face-to-target angles showed significant interactions between three conditions (Set 1, Set 2, and Set 3) and two groups (AGs and SGs); SGs consistently displayed smaller angles in every set than their amateur counterparts (p0.5). A post-hoc test further increased the discrepancy between Sets 2 and 3 for AGs and SGs. In addition, a strong correlation was found between each participant’s average number of strokes and the mean clubhead speed (CHS) across 15 driver shots. A stepwise multiple regression analysis indicated that CHS was a significant predictor of a player’s average number of strokes. Conclusion: SGs achieved extremely accurate clubface control during multiple hits with a high CHS. We found no trade-off relationship between a higher CHS and smaller face-to-target opening/closing in SGs.
Taxonomic review ofSaguinus mystax(Spix, 1823) (Primates, Callitrichidae), and description of a new species
Authors: Lopes Gerson Paulino , Rohe Fábio , Bertuol Fabrício , Polo Erico , Lima Ivan Junqueira , Valsecchi João , Santos Tamily Carvalho Melo , Nash Stephen D. , Silva Maria Nazareth Ferreira da , Boubli Jean P. , Farias Izeni Pires , Hrbek Tomas
Published: January 2023

Although the Amazon has the greatest diversity of primates, there are still taxonomic uncertainties for many taxa, such as the species of theSaguinus mystaxgroup. The most geographically broadly distributed and phenotypically diverse species in this group isS.mystax, and its phenotypic diversity has been recognized as three subspecies—S.mystax mystax,S.mystax pileatusandS.mystax pluto—with non-overlapping geographic distributions. In this sense, we carried out an extensive field survey in their distribution areas and used a framework of taxonomic hypothesis testing of genomic data combined with an integrative taxonomic decision-making framework to carry out a taxonomic revision ofS. mystax. Our tests supported the existence of three lineages/species. The first species corresponds toSaguinus mystax mystaxfrom the left bank of the Juruá River, which was raised to the species level, and we also discovered and described animals from the Juruá–Tefé interfluve previously attributed toS.mystax mystaxas a new species. The subspeciesS.m.pileatusandS.m.plutoare recognized as a single species, under a new nomenclatural combination. However, given their phenotypic distinction and allopatric distribution, they potentially are a manifestation of an early stage of speciation, and therefore we maintain their subspecific designations.
Boswellia serrata Roxb. Ex Coleb.: A Threatened Tree
Authors: Warrier Kannan C. S. , Muthupandiyan S.
Published: January 2023

Boswellia serrata Roxb. ex Coleb. is commonly known as Indian Olibanum or Indian Frankincense tree.  It belongs to the family Burseraceae.  The tree is confined to Tropical Dry Deciduous Forest of India.  It grows at altitudes up to 1,150 m in regions with annual temperatures between 0-45°C and annual rainfall between 500-2,000 mm.   B. serrata has been listed in the threatened species of India. The principal threats of this species are slow growth coupled with poor regeneration. However, the population trends and habitat trends are stable.  Due to its exudations of volatile oil, resin and gum, the tree has attained commercial significance. The oil obtained from this tree is very similar to turpentine oil and found suitable for paint making, varnish and used as printing ink in textile industries and in making distempers. It is a unique non coniferous source of turpentine employed for the manufacture of paints and varnishes. The resin obtained from this tree is used for preparation of varnishes. The tree exudes of B. serrata resembles Canada balsam in colour and consistency. It is mainly used for medicinal purposes and incense. A detailed review covering its taxonomy and nomenclature, distribution in India, reproductive biology, wood properties, processing and harvesting, genetic resources available, reasons for its deterioration, and its uses is presented in this article.
Dorsal approach for advanced gastric cancer invading the transverse mesocolon
Authors: Okabe Hiroshi , Aoyama Hiroki , Miyahara Yoji , Sunagawa Hideki
Published: January 2023

Minimally invasive gastrectomy is increasingly performed for advanced gastric cancer, but the indication for this procedure for a tumor invading adjacent structures is still limited. In cases with tumors invading the transverse mesocolon, a large tumor together with the involved mesocolon blocks the surgical view, which prevents evaluation of the extent of invasion and makes it difficult to ensure oncologically adequate resection. To solve these technical issues, we established a novel method that uses a dorsal approach. By approaching the transverse mesocolon from the dorsal side, tumor penetration and involvement of the colic vessels or pancreas can be evaluated, and margin‐free resection of the tumor becomes easier. In a series of 13 patients with mesocolon invasion, a dorsal approach enabled minimally invasive margin‐free resection in 11 cases by resection of the anterior layer of the mesocolon (n = 6); enucleation of the mesocolon (n = 4); or enucleation plus distal pancreato‐splenectomy (n = 1). Two patients with broad invasion that obstructed the view underwent combined colectomy by open conversion. A major postoperative complication of pancreatic fistula following distal pancreatectomy occurred in one case. These results suggest that a dorsal approach may be useful for minimally invasive combined resection of gastric cancer invading the transverse mesocolon.