bluuebunny/crossref_metadata_2025 huggingface dataset:
Perfil da mulher gestante com sífilis na maternidade pública
Authors: Zuzarte Jannyne Dos Santos , Santos Inês Maria Meneses dos , Silva Alexandre Sousa da , Silva Luan Claudio de Oliveira , Santos Vinícius Ferreira dos , Rebello Patzy Dias
Published: November 2020

A sífilis em gestantes persiste no Brasil, no período entre o ano de 2005 a junho de 2016, foi notificado no Sistema de Informação de Agravos de Notificação, um total de 169.546 casos de sífilis em gestantes, com maior índice na região Sudeste. O não tratamento adequado da sífilis pode gerar um aumento do problema de saúde pública, com internações hospitalares, gastos públicos e aumento do índice da sífilis congênita no Brasil. O objetivo do trabalho foi caracterizar o perfil da mulher gestante internada no setor de Acolhimento e Classificação de Risco. Trata-se de um estudo quantitativo, descritivo, transversal. Foi utilizado o Programa R® versão 3.5.1. Realizou-se a análise estatística através da confecção de testes de hipótese para realização de inferências fidedignas; matematicamente prováveis e confecção de gráficos para elucidação da distribuição das variáveis.  Optou-se por adotar 0,05 como nível de significância. Quanto aos resultados e discussões obteve-se maior incidência de gestantes com sífilis na faixa etária entre 20 a 29 anos, com escolaridade até o ensino fundamental completo e de raça negra. Os dados analisados nesta pesquisa permitiram caracterizar o perfil das mulheres ao momento do diagnóstico da sífilis com a escolaridade, a idade, a raça, as que realizaram e não realizaram pré-natal, e com que as fizeram e não fizeram o tratamento.  Percebe-se que a falta de adesão à educação tem forte influência nas vidas dessas mulheres no que tange a sífilis em gestantes.
Pâncreas ectópico: revisão de casos clínicos, abordagem diagnóstica e terapêutica
Authors: Ribeiro Dayane Adenir Shizuko Takata , Toledo Caroline Rossati , Zardeto-Sabec Giuliana
Published: November 2020

Introdução: O pâncreas ectópico (PE) consiste em uma malformação congênita, considerada rara, definida como a presença de um tecido pancreático fora da sua localização topográfica habitual, com sistema ductal e vascularização independente. A grande maioria dos casos de PE são assintomáticos, porém quando o paciente é sintomático, pode manifestar-se através de hemorragias, inflamações, obstruções de estruturas anatômicas adjacentes, complicações como a pancreatite e transformações malignas como o adenocarcinoma. Objetivo: Sendo assim, o objetivo do presente trabalho foi de realizar uma revisão a respeito de casos de ectopia pancreática e pancreatite associada a pâncreas ectópico, bem como abordagem diagnóstica e terapêutica perante a suspeita dessa enfermidade. Metodologia: Para isso, foi desenvolvido uma revisão integrativa, de estudos que abordam a temática pâncreas ectópico, incluindo abordagem retrospectiva de casos clínicos publicados desde 2009 até 2017. As bases de dados consultadas para esta pesquisa foram: LILACS (Literatura Latino Americana e do Caribe em Ciências da Saúde), a biblioteca SciELO (Scientific Electronic Library on Line) e PubMed (National Center for Biotechnology Information - NCBI, U.S. National Library of Medicine), Google acadêmico®. Resultados e discussão: Trata-se de uma doença com incidência aproximada de 0,5%-15% em autópsias e de 1 a cada 500 cirurgias abdominais. Com base em um estudo com 11.265 pacientes verificou-se 24 (0,21%) heterotopias abdominais, das quais a pancreática foi a mais comum (0,12%). Conclusão: Neste sentido, conclui-se que o PE é uma malformação congênita, rara; a maioria dos pacientes possui evolução assintomática, porém, quando presentes, os sintomas são inespecíficos, o que torna o diagnóstico difícil, sendo este realizado através de exames radiológicos, endoscopia do trato digestivo ou através de achados cirúrgicos incidentais. Sugere-se que mais estudos acerca do assunto são necessários para que o paciente seja diagnosticado e tratado rapidamente.
Cost minimization and financial impact of root canal therapy techniques: manual, rotary and reciprocating
Authors: Pinheiro Polyana Santiago Marques , Garcia Sylvanne Lucila da Silva , Machado Victor Coutinho Mello , Simoes Ana Clara Correa Duarte , Merchan Laura Paredes , Raimundo Augusto Cesar Santos , Cavalcante Denise de Fátima Barros , Pereira Antonio Carlos
Published: November 2020

The root canal therapy consists of phases aimed at cleaning and disinfection of the root canal system. The chemomechanical preparation is the one that makes use of instruments that can be used by means of mechanized techniques (rotary and reciprocation) and manual. The present study seeks to compare the three instrumentation techniques, based on cost and outcome, using the cost – minimization analysis in the perspective of the Social Service of Commerce (SESC - Brazil), and a time horizon of 10 years. The effectiveness of the techniques were raised through literature review and selection of systematic review studies. The costs were measured by the microcosting technique, in addition to the information from the SESC databases. In the analyzed period, the study shows that the use of the rotary system can increase the capacity of care by 44,67%, while the reciprocation system by 168 %.  The financial impact would be R$ 103,683.87 and R$ 735,179.46 for the rotary and reciprocation, respectively. Using as reference the conventional technique, R$ 44.58 more is spent for the treatment with rotary instruments and R$ 84,03 for the reciprocation. Even with the highest allocating efficiency for the reciprocating technique with much greater coverage, the budget impact needs to be analyzed with caution. The incorporation of reciprocating technology demonstrating to be the technique with the highest allocating efficiency, best minimization cost ratio and reasonable cost of additional treatment in relation to other techniques.
Arte-educação e libertação humana
Authors: Farias Carla Galvão , Oliveira Milene kinlliane Silva de , Dias Polyana Nogueira
Published: November 2020

Este artigo traz algumas reflexões sobre os conceitos de arte-educação e libertação humana, considerando, para tal, o ensino de Artes na Educação Básica, de acordo com a Lei de Diretrizes e Bases nº 9.394/96, da lei 13.278/16 e os desafios que permeiam esse ensino-aprendizagem. Trata-se de uma pesquisa de cunho Bibliográfica, que consiste em relacionar os pensamentos de dois autores: as concepções de arte-educação em Duarte Jr. (2010, 2012) e os conceitos de práticas “bancárias” na educação, de “ser mais”, de libertação humana e de autonomia em Paulo Freire (1996, 2011). Visando encontrar aproximações nos estudos dos referidos autores sobre as práticas de ensino e os modos de se estimular a autonomia dos educandos.  Conclui-se que a arte-educação vai ao encontro da autonomia, por respeitar a subjetividade e promover práticas de ensino-aprendizagem que compreendem o ser humano de forma integral, ou seja, o corpo também é considerado importante no processo de aprendizado, não apenas a mente. Por isso, as emoções e experiências de vida são acolhidas.
Systemic arterial hypertension: treatment with Integrative and Complementary Health Practices
Authors: Pinheiro Isabelle Matos , Montes Simone de Souza , Fraga Hilda Carolina de Jesus Rios , Souza Reinaldo dos Santos , Pinheiro Igor de Matos , Machado Aline de Oliveira , Lima Silvana Batista Passos , Coelho Julita Maria Freitas , Macedo Marcio Cerqueira , Souza Elias Ramos de , Saba Hugo , Jorge Eduardo Manuel de Freitas , Sampaio Romilson Lopes , Batista Wilson Otto , Araujo Marcio Luis Valença , Benevides Clicia Maria J. , Souza Antonio Carlos dos Santos
Published: November 2020

Systemic Arterial Hypertension (SAH) can generate complications such as stroke, myocardial infarction, kidney disease, arteriosclerosis, loss of vision, erectile dysfunction and cognitive dysfunction. Among people who know they suffer from hypertension, 50% use medication and of those only 45% have their blood pressure kept under control. SAH is a multifactorial clinical condition characterized by elevated and sustained blood pressure levels (BP, where systolic BP ≥ 140 mmHg and diastolic BP ≥ 90 mmHg). Faced with sparse investigative studies on the causes of SAH in individuals, the dictates of the pharmaceutical industry and the use of in vitro or inconclusive clinical studies, this paper presents the state of the art about the treatment of SAH based on a multifaceted view, including aspects about the physiology of SAH, food and PANC as alternatives for the prevention and control of SAH, as well as an approach on the importance of scientific rigor in the manufacture of medicines.
Manejo da radiodermite em pacientes oncológicos: revisão integrativa
Authors: Tanaka Raquel Yurika , Monteiro Daiane da Rosa , Souza Tábata de Cavatá
Published: November 2020

A radiodermite afeta diretamente a qualidade de vida dos pacientes submetidos à terapia radioterápica por serem dolorosas, podendo ocorrer infecções locais e sistêmicas em alguns casos. Por se tratarem de feridas complexas de difícil cicatrização, as lesões cutâneas pela radiodermite podem ter repercussões, com estigma social e pessoal, pelas alterações na imagem corporal, principalmente nos casos de quem irradia regiões como a cabeça, pescoço e mamas. O presente estudo teve como objetivo verificar quais as recomendações e evidências científicas para o manejo da radiodermite em paciente oncológicos, na literatura nacional e internacional. Trata-se de um estudo de revisão integrativa com cinco artigos científicos selecionados nos últimos dez anos, através da base de dados da Biblioteca Virtual em Saúde. Três publicações avaliadas com delineamento descritivo e transversal, nas quais foram respondidos questionários sobre a atuação do profissional enfermeiro frente ao manejo de radiodermite. Destacou-se a necessidade do uso de escalas de avaliação para caracterização da toxicidade induzida pela radiação e o desenvolvimento de protocolos clínicos para promover melhorias na prática assistencial com padronização de condutas, baseada em evidência cientifica. Verificou-se que nesta revisão integrativa não houve dentre as publicações analisadas nenhum produto que demonstrou eficácia no manejo tópico da radiodermite. Enfatiza-se a necessidade de realizar mais estudos experimentais como ensaios clínicos, randomizados, controlados e multicêntricos para embasar a prática baseada em evidências.
Synthesis and characterization of four new lanthanide complexes coordinate with β-diketone ligands and 1,10-phenanthroline or 2,2-dipyridine
Authors: Brito Yuri Johann Vilar de , Morais Crislene Rodrigues da Silva , Brito Yohanna Jamilla Vilar de , Bezerra Daniella Cibele
Published: November 2020

In this work the complexes Ln(β-dik)3L (where Ln= Nd+3 e Er+3, β-dik= 4,4,4-trifluoro-1-phenyl-1,3-butanedione (Btfa) and L= 1,10-Phenanthroline (Phen) or 2,2’-Bipyridyl (Bipy)), were synthesized from the direct reaction of LnCl3 with β-diketone and the ligands. The purpose was to create new lanthanide complexes with perspectives of use in markers. After the syntheses, the complexes were characterized by Solubility Test, Scanning Electron Microscopy (SEM) and the thermal properties of compounds were studied using Thermogravimetry Analisys (TGA), Differential Scanning Calorimetry (DSC) and Determination of Melting/Decomposition Intervals. Based on the verified properties, the solubility test found that the complexes are not soluble in chloroform and water. The microscope images showed an excellent crystallization of the complexes. The complexes are stable up to 120°C, after this temperature they show a peak in the DSC referring to the fusion and the beginning of decomposition. The values of activation energy suggests the following decreasing order of stability: Er(Btfa)3Phen>Nd(Btfa)3Phen>Er(Btfa)3Bipy>Nd(Btfa)3Bipy.
Fermented rice bran: an alternative ingredient in baking
Authors: Christ-Ribeiro Anelise , Alves Janaína Barreto , Souza-Soares Leonor Almeida de , Badiale-Furlong Eliana
Published: November 2020

The idea that associated agro-industrial by-products only with the production of animal feed has been gradually being replaced, as the scientific community is interested in these products, as low-cost nutrients for the composition of food and/or culture media in research biotechnological to increase or improve nutrients or characteristics inherent in the raw material. Thus, this work aims to characterize input for baking with claim of natural fortification from the fermentation by Saccharomyces cerevisiae. For this, biomass was characterized in terms of its composition (ashes, fibers, lipids, proteins, and carbohydrates) and antioxidant activity of phenolic compounds. The results show an increase in nutrients such as ash, proteins and fibers, in addition the free and bound phenolic compounds present in the biomass showed antioxidant potential. Therefore, fermented rice bran is a potential input to be used in baking.
AN INTEGER PROGRAMMING APPROACH FOR SINGLE TRUCK ROUTING-AND-SCHEDULING PROBLEMS TO ISLANDS WITH TIME-VARYING FERRY SCHEDULES
Authors: Afifudin Mohammad Thezar , Sahar Dian Pratiwi
Published: November 2020

This study aims to develop a solving model for the single trucks routing-and-scheduling problems to islands with variations in ferry schedules. In this problem, the travel time is asymmetric and the truck routing is based on the sequence of island visits, known and unknown. The models are developed using an integer programming approach. Integer non-linear programming is formulated to solve problems where the sequence is unknown, whereas integer linear programming for the sequence is known. Besides, a delivery day scenario is built to determine the optimal route and schedule with minimum total travel time on each departure day. Numerical experiments were carried out on the case of a small distribution of a small industry in Central Moluccas, Indonesia. The results showed that the model developed could provide solutions to solve problems.
FACILITY LAYOUT PLANNING IN SMALL INDUSTRY TO INCREASE EFFICIENCY (CASE STUDY: BIG BOY BAKERY, BATAM, KEPULAUAN RIAU, INDONESIA)
Authors: Hanggara Fuad Dwi
Published: November 2020

In the food industry competition in Indonesia, Big Boy Bakery which is a small-scale food industry competes with the food industry both small and large scale. This pressured Big Boy Bakery to continue to grow both in increasing the quality and quantity of production. One method that will be used is planning the layout of facilities at the production site so that it becomes the basis for consideration of the placement of important elements in the design of the construction of future production sites. Facility layout is carried out because there are differences in the distance between production operations and other production operations which cause inefficiencies in productivity. In this problem approach the method used in Big Boy Bakery layout planning is the Systematic Layout Planning (SLP) method. The function of SLP is to improve the layout of Big Boy Bakery, by finding alternatives that have been considered with important elements in production operations that have been taken into account at either the level of interaction, or other needs. Placement of important elements such as proper production operations, will reduce travel costs, and waste time, so that the planned layout can provide increased productivity efficiency. With the proposed spatial planning made, it is hoped that it can make a significant contribution to the development of Big Boy Bakery.
ERGONOMIC EVALUATION OF STUDY DESKS AND CHAIRS USING ANTHROPOMETRY AND BIOMECHANICAL APPROACH AT AN-NURIYAH ISLAMIC BOARDING SCHOOL BONTOCINI JENEPONTO REGENCY
Authors: Afiah Irma Nur
Published: November 2020

School is one of the places to study. Therefore, it requires facilities to support the sustainability of the process of teaching and learning to teach such as study desks and study chairs. However, when the activity of writing is performed using study desks and chairs, students tend to lean to the front, slouch and dangle their feet. Evaluation of the products ergonomically has to be adjusted with the usage in order that they are not going to cause various negative impacts for students that will take place in both the short term and the long one. As a consequence, this study is important to carry out to minimize the mismatch of study desks and chairs with students and to obtain the redesigned results of study desks and study chairs ergonomically. The anthropometric approach was used for the dimensions of the human body in the design of study desks and chairs.  In addition, the biomechanical approach was utilized to evaluate good sitting position for students. The evaluation was observed from the calculation of compression pressure, which is the load that occurs in the neck and lumbar. The results of the design of the proposed study desks and chairs are more ergonomic and can accommodate anthropometric users; hence, parts of the study desks and chair can minimize the complaints perceived by students. Through the biomechanical approach, the results obtained the angle surface of the table of 200, the slope of the seat rest of 100º and the seat slope of 50º
STUDI OF SREAM DISTRIBUTION AND BOILER PERFORMANCE INDOMARINE AT PT. EASTERN PEARL FLOUR MILLS
Authors: Hamid Naim
Published: November 2020

The process of making pellets at PT. Estren Pear flour Millss require hot steam generated from the Indomarine boiler. This study aims to determine the performance of Boier Indomrine. The research method used is to collect measured data on instruments and stored in the control documents of PT. Eastern Pearl Flour Mills. The results of the calculation show that the heat energy loss in the distribution pipe installation is 32.5 kW, while the available fuel energy from the combustion process is 2334311 kJ / hour. mass balance of the working fluid that occurs is the mass rate of feed water used is 1126.35 kg / hour, the mass rate of steam produced is 934.35 kg / hour. While the rest came out through the blow down process of 192 kg / hour.
HUMAN ERROR IDENTIFICATION IN BUS DRIVER WORK USING SHERPA AND HEART
Authors: Susilo Mitasya
Published: November 2020

Traffic accidents, especially with a large capacity such as bus, can be caused by several factors. According to the Indonesian Directorate General of Land Transportation of the Ministry of Transportation in 2012, the factors causing traffic accidents in Indonesia are a human factor of 93.52%, vehicle factor by 2.76%, road factor 3.23%, and environmental factor by 0.49%. Therefore, research is needed to identify which human error has the greatest probability of accident cause using Systematic Human Error Reduction and Prediction Approach (SHERPA) method to identify job desk using Hierarchical Task Analysis (HTA) and Human Error Assessment Reduction Technique (HEART) method to calculate Human Error Probability (HEP). Based on the calculation of Human Error Probability value known the highest HEP value is not running the vehicle in accordance with the provisions of the speed that has been set with 0.375. Next is not to record or forget to record the damage that occurred during the trip with a value of 0.21. It did not check Bus equipment with a HEP value of 0.19, did not report when there was a problem on the street with a HEP value of 0.18 and did not break for the next preparation for departure with a HEP value of 0.15
5 MEKANISME PIKIR SEBAGAI TEKNIK PENGEMBANGAN KERANGKA KARANGAN
Authors: Pramulia Pana Pramulia
Published: November 2020

Short stories are a type of prose that does not have a lot of conflict and there are not many characters in it, but has a complex unanimity. However, writing short stories is not easy, because it requires imaginative power and qualified creativity in expressing ideas and processing language. Imaginative processes and creativity do not just exist, but need to be trained intensively and continuously. There are many strategies for writing short stories, especially for beginner writers. The first is compiling the outline of the essay, the second is using the idea development technique. One of the techniques in compiling the outline of the essay is using the cilukba pattern technique. For the technique of developing an essay framework, you can use the 5 thought mechanism technique. Techniques for 5 thought mechanisms, including developing, shrinking, increasing, decreasing, and sideways. This pattern will be used by PGSD students of PGRI Adi Buana University Surabaya class of 2016 to write short stories. The methods used include lecturers making themes, students are tasked with compiling an essay framework based on cilukba patterns, students are tasked with learning the 5 thought mechanism techniques, and students are tasked with developing an essay framework based on the 5 thought mechanism techniques. Based on this, PGSD students of PGRI Adi Buana University Surabaya class of 2016 can write short stories well and can collect these short stories into a collection book ISBN of short stories.
Impact of IMRT- and VMAT technologies on selection of total dose of radiation therapy in patients with squamous cell carcinoma of anal canal
Authors: Glebovskaya V. V. , Tkachev S. I. , Borisova T. N. , Trofimova O. P. , Ivanov S. M. , Alieva S. B. , Romanov D. S. , Mamedli Z. Z. , Gordeev S. S. , Besova N. S.
Published: November 2020

Accurate determination of the tumor with the use of modern diagnostic methods which make the maximum exposure to the tumor and the identified affected lymph nodes possible lead to careful attitude to healthy tissues and critical structures. During the period 2000-2015 301 patients with squamous cell carcinoma of the anal canal stage T1-4N0-3M0-1 completed complex treatment which consisted of radiation therapy in a conventional or conformal mode, including the use of modern technologies - radiation therapy with intensity modulation - IMRT and arch volume-modulated radiation therapy - VMAT. The use of IMRT andVMAT in comparison with conformal radiation therapy allowed to reduce the frequency of unplanned interruptions up to 48 % (p = 0.005), which led to increase in 5-year rates of local regional control - 83.7 % compared with the group where the interruption was applied - 74.2 % (p = 0.049); also increased the frequency of complete responses in the range of the total dose of 50-54 Gy to 28.5 %, 56-58 Gy to 44.3 % and 60-64 Gy to 26.1 %. The achievement of a complete response led to a significant increase in the 92.1 % 5-year locoregional control compared to the group with the absence of a complete response - 76.5 % (p = 0.001). Modern conservative treatment is based on continuous radiation exposure with the absence of intervals between courses, which is the radiobiologically considered the most effective treatment regimen.
Surgery and metastases of stomach cancer in liver
Authors: Dzhuraev F. M. , Gutorov S. L. , Borisova E. I. , Khakimova G. G.
Published: November 2020

Liver metastases of gastric cancer determine the poor prognosis. Until now The expediency of their surgical removal has been controversial. However, according to a number of studies, the removal of potentially operable isolated liver metastases allows a significant increase of overall and relapse-free survival in some cases. The review is dedicated to the analysis of prognostic factors that allow selecting patients for surgical removal of liver metastases of gastric cancer. The main criteria are: effective perioperative chemotherapy; stage under T4, N0, absence of lymphovascular invasion, absence of peritoneal dissemination, number less than 3, size up to 4 cm, localization of metastases in one lobe, low level of cancer markers CA 19-9 and CEA.
Subpopulation composition of tumor-infiltrating lymphocytes in luminal breast cancer and its effect on effectiveness of neoadjuvant chemotherapy
Authors: Kovalenko E. I. , Artamonova E. V. , Zabotina T. N. , Kadagidze Z. G. , Bagrova S. G. , Kiselevsky M. V. , Vorotnikov I. K. , Denchik D. A. , Kuzmina V. I. , Zakharova E. N. , Shoua E. K. , Zhulikov Ya. A. , Khoroshilov M. V. , Egorova A. V. , Haylenko V. A.
Published: November 2020

Tumor-infiltrating lymphocytes (TILs) play a key role in the formation of anti-tumor immunity and, as studies have shown, can be one of the markers of treatment effectiveness and cancer prognosis. The aim was to study the subpopulation composition of the lymphoid infiltrate in early luminal breast cancer in patients receiving neoadjuvant chemotherapy (NACT) and its effect on achieving a pathological complete response (pCR). Materials and methods. We included 24 patients who received anthracycline-taxane-contain-ing preoperative chemotherapy. The subpopulation composition of TIL was assessed in core-biopsy samples before starting NACT in all patients; after treatment, the assessment was made on postoperative material. The analysis was carried out by flow cytometry. Clinical and immunological assessment was carried out for the following seven subpopulations of lymphocytes: CD3+, CD3+CD4+, CD3+CD8+, CD4+CD127+CD25+, CD3 CD19+ CD3CD16+CD56+, CD3+CD16+CD56+. Results. The incidence pCR was 16.7 %. It was revealed that the initial level before treatment of CD3+, CD3+CD4+, CD3+CD8+, CD4+C-D127+CD25+, CD3-CD19+, CD3 CD16+CD56+, CD3+CD16+CD56+ lymphocytes did not differ depending on the stage of the disease (II or III), tumor subtype (luminal A/B) and Ki-67 level (up to 20, 20-39, 40 and more). No correlations were found between Ki-67 and TIL content. When conducting regression analysis, it was revealed that only the level of CD3+, CD3+CD8+ and CD19+ was a significant factor in achieving a pCR (p = 0.005). When an empirical subgroup was identified, which was characterized by a high content (above or equal to the median) of CD3+, CD3+CD8+ and low (below the median) CD19+ (four observations), the frequency of pCR reached 75 %. Conclusion. Thus, the initial level of T-lymphocytes (CD3+, CD3+CD8+) and B-lymphocytes (CD19+) in the tumor, regardless of the stage of the disease, tumor subtype, ki-67 index, was a predictor of high sensitivity to neoadjuvant chemotherapy of luminal breast cancer and was associated with higher frequency of pCR.
Use of botulinum toxin type A in reconstructive surgery in patients with breast cancer (literature review)
Authors: Dalgatova P. O. , Starkova M. V. , Vlasova M. Yu. , Zikiryakhodzhaev A. D. , Alekseeva G. S. , Reshetov I. V. , Usov F. N. , Maksimov K. V.
Published: November 2020

According to the analyzed literature, the use of botulinum toxin type A is promising as an auxiliary method for simultaneous or delayed breast reconstruction using a subpectoral silicone implant or tissue expander. This method is safe and simple. Relaxation of the large pectoral muscle both intraoperatively and in the postoperative period reduces the intensity of pain, accelerates the rehabilitation of patients. Botulinum toxin therapy prevents the animation and deformation of the reconstructed breast. The effect after injection of botulinum toxin persists for 6-8 months and for a long time there is no need for analgesic therapy. According to the literature, this technique for reconstructive plastic surgery in patients with breast cancer significantly improves the quality of life of patients by reducing pain, preventing deformation and contraction of the large pectoral muscle. Conclusion. The literature analysis evaluates the effectiveness of botulinum toxin preparations for pain after reconstructive plastic surgery on the breast using a subpectoral space. The possibilities of therapeutic use of botulinum toxin preparations as an analgesic are known, but are little used in practice. This direction is promising. Given the small number of literary publications on this subject, it is necessary to conduct further research in this direction.
Affective disorders as risk predictor of developing cancer on example of malignant tumors of pancreas
Authors: Pavlovsky A. V. , Moiseenko V. E. , Popov S. A. , Gadzhieva F. Sh. , Rukavishnikov G. V. , Mazo G. E. , Kovenko A. E.
Published: November 2020

Pancreatic cancer is the 12th most common malignant neoplasm and the 7th most common cancer related death worldwide. Early diagnosis of pancreatic cancer is complicated, since the disease proceeds for a long time without pronounced clinical symptoms, and the identification and screening of the so-called risk groups of patients is difficult, since the etiology of pancreatic cancer is currently a matter of scientific debate. Early diagnosis of pancreatic cancer can be based on the anamnestic analysis of the psychoemotional status of patients. Back in the early 20th century, based on an analysis of the results of a survey of patients with pancreatic cancer, researchers described a triad of affective signs, including depression, anxiety and a sense of impending death, which worried patients in the early stages of development of the disease. According to literature, the psychiatric symptoms of pancreatic cancer can appear 43 months before the somatic symptoms and occur in more than 50 % of patients. To date, there are a number of concepts in the literature that point to a significant contribution of affective disorders to the development of pancreatic cancer. The aim of this review is to analyze the literature data on the relationship between affective disorders and the development of pancreatic cancer.
Late COVID-19 metastatic colorectal cancer therapy: to start or to delay?
Authors: Artamonova E. V.
Published: November 2020

In the context of the COVID-19 pandemic, the multikinase inhibitor regorafenib is an important option for systemic treatment of metastatic colorectal cancer (mCRC) after oxaliplatin, irinotecan, and fluoropyrimidine ± biologics. Regorafenib inhibits various protein kinases implicated in oncogenesis, angiogenesis, and the tumour microenvironment. In two placebo-controlled, randomized, phase III trials treatment with regorafenib was associated with prolonged overall survival and progression-free survival in heavily pretreated patients and clinical benefit was consistent across various patient subgroups. The benefit provided by regorafenib was confirmed in observational studies designed to characterize safety and effectiveness in an unselected, real-world population of patients with mCRC. Both immunotherapy (atesolizumab) or combination of target plus immunotherapy (cobimetinib plus atezolizumab) did not prolong overall survival compared to regorafenib in phase III trial IMblaze, where regorafenib was used as the standart of care in the control arm because it is approved globally in the treatment setting tested in the study. New data show that regorafenib can positively interfere with the immunosuppressive state, increasing the immunosensitivity of the tumor or the tumor microenvironment. Regorafenib has increased activity in earlier lines of therapy vs later lines of therapy (when patients tend to benefit to a lesser degree) and clinical date provide evidence for the use of regorafenib before chemotherapy rechallenge or anti-EGFR monotherapy.
Broadband integrated optical modulators: achievements and prospects
Authors: Petrov V M , Agruzov P M , Lebedev V V , Il’ichev I V , Shamray A V
Published: November 2020

Broadband integrated optical modulators are key elements of modern optical information systems. The three main technological material platforms for their manufacture are considered: lithium niobate, III–V semiconductors, and silicon. Progress achieved in the development of integrated optical modulators is analyzed, and the main parameters of modulators obtained for various materials are compared with requirements for practical applications. Directions in the further development of the technology of modulators related to new problems in optical information systems are discussed.
Compressible vortex structures and their role in the onset of hydrodynamic turbulence
Authors: Agafontsev D S , Kuznetsov E A , Mailybaev A A , Sereshchenko E V
Published: November 2020

We study the formation of quasi-two-dimensional (thin pancake) vortex structures in three-dimensional flows and of quasi-one-dimensional structures in two-dimensional hydrodynamics. These structures are formed at large Reynolds numbers, when their evolution is described in the leading order by the Euler equations for an ideal incompressible fluid. We show numerically and analytically that the compression of these structures and, as a consequence, the increase in their amplitudes are due to the compressibility of the frozen-in-fluid fields: the field of continuously distributed vortex lines in the three-dimensional case and the field of vorticity rotor lines (divorticity) for two-dimensional flows. We find that the growth of vorticity and divorticity can be considered to be a process of overturning the corresponding fields. At high intensities, this process demonstrates a Kolmogorov-type scaling relating the maximum amplitude to the corresponding thicknesses-to-width ratio of the structures. The possible role of these coherent structures in the formation of the Kolmogorov turbulent spectrum, as well as in the Kraichnan spectrum corresponding to a constant flux of enstrophy in the case of two-dimensional turbulence, is analyzed.
Application of the modified Duguay method for measuring the Lorentz contraction of a moving body length
Authors: Malykin G B
Published: November 2020

According to Lorentz transformations, for a stationary observer, time in a moving inertial reference frame slows down, while the linear dimensions are reduced. While the first effect was observed more than 80 years ago, the second one has not been directly observed so far. The modified Duguay method is proposed in this paper for measuring the Lorentz contraction of a moving body length using the propagation of light pulses in an optical liquid medium. Three variants of the measurement scheme are considered: with a ‘light square’ in an optical medium, with a ‘light ruler’ in two optical media with different refractive indices, and with two relativistic electron bunches in a vacuum. It is shown that the classical effect of compression of spatial intervals between light pulses in an optical medium, which was not considered earlier, considerably reduces the measurement accuracy. It is also shown that the distortion of the sides of a light square oriented orthogonal to the movement direction caused by the different delays of light from different parts of a moving body also reduces the measurement accuracy of the light square method.
Gas envelopes of exoplanets — hot Jupiters
Authors: Bisikalo D V , Shematovich V I , Kaygorodov P V , Zhilkin A G
Published: November 2020

We consider the physical characteristics and dynamics of the gaseous envelopes of hot Jupiters (HJs) — gas giants with a mass comparable to Jupiter’s and a semi-major axis of less than 0.1 a.u. Although HJs were discovered almost a quarter of a century ago, many issues about their origin remain open. There are two reasons for the scientific interest in HJs. The first is the absence of such planets in the Solar System, which is challenging in all cosmogonical theories. The second is that the exoplanet atmospheres’ characteristics can now be derived primarily for transit HJs by examining their absorption spectra. Thanks to their large size, such planets can be readily observed, as opposed to others, and their transits can be observed at much higher orbital inclinations. Comparatively recently, in at least some HJs, extended gas envelopes far exceeding their Roche lobes have been found. The paper focuses on the results of theoretical investigations and numerical modeling of the dynamics of HJ envelopes. We also discuss experimental testing of the obtained results and predictions using the planned Russian Spectrum-UV (international name: WSO-UV) and Millimetron space telescopes.
Security of the decoy state method for quantum key distribution
Authors: Trushechkin A S , Kiktenko E O , Kronberg D A , Fedorov A K
Published: November 2020

Quantum cryptography or, more precisely, quantum key distribution (QKD), is one of the advanced areas in the field of quantum technologies. The confidentiality of keys distributed with the use of QKD protocols is guaranteed by the fundamental laws of quantum mechanics. This paper is devoted to the decoy state method, a countermeasure against vulnerabilities caused by the use of coherent states of light for QKD protocols whose security is proved under the assumption of single-photon states. We give a formal security proof of the decoy state method against all possible attacks. We compare two widely known attacks on multiphoton pulses: photon-number splitting and beam splitting. Finally, we discuss the equivalence of polarization and phase coding.
Characterization of Pseudomonas syringae pv. syringae from Diseased Stone Fruits in Kyrgyzstan and Testing of Biological Agents against Pathogen
Authors: Doolotkeldieva Tinatin , Bobusheva Saikal
Published: November 2020

The plant diseases caused by the Pseudomonas syringae сomplex bacteria are economically important and occur worldwide on various plants, and it is as a pathogen that has not been the object of studies and little is known about its epidemiology in Kyrgyzstan. The conventional phenotypic (LOPAT, API tests) and PCR-assisted isolation were used for the identificationof Pseudomonas syringae pv. syringaе isolates from the affected organs of local stone fruits, such as peach (Prunus persica), cherry (Prunus subgen), apricot (Prunus armeniaca), and plum (Prunus salicina) samples taken from the Chy, Issuk-Kul, and Batken regions of the country. 16S rRNA gene amplification was performed with primers 27F (5'-AGA GTT TGA TCC TGG CTC AG -3') and 907R (5 '–CCG TCA ATT CCT TTG AGT TT-3') for the identification of obtained P.syringae pv. syringaе isolates. From 40 primary isolates of Gram-negative rod-shaped bacteria, 12 were identified as Pseudomonas syringae pv. syringae, while the remaining isolates were identified as bacteria from Stenotrophomonas, Xanthomonas, Erwinia genera. The antagonist bio control agent—Streptomyces bacteria strains were screened and selected against the bacterial canker pathogen in in vitro experiments and on apricot seedlings in vivo conditions. Obtained results could encourage to develop a local bio-product based on this bioagent for spraying stone fruits with the initial manifestation of disease symptoms and to conduct preventive treatments in the fall and spring to increase the plant's resistance to pathogens.
Evaluation of CIMMYT Wheat Lines under Egyptian Field Conditions to Identify New Sources of Resistance to Leaf Rust
Authors: El-Orabey Walid Mohamed , Awad Hosam Mohamed , Shahin Sabry Ibrahim , El-Gohary Yasser Ahmed
Published: November 2020

Leaf rust caused by Puccinia triticina Eriks. is a fungal disease of wheat (Triticum aestivum L.), which causes considerable yield loss. Host resistance is the most effective and economical method to minimize yield losses caused by leaf rust. The current research was planned to evaluate the response of 93 wheat genotypes lines selected from 716 wheat genotypes delivered to Egypt by International Maize and Wheat Improvement Center (CIMMYT). These genotypes were evaluated against leaf rust resistance under field conditions at two locations i.e. Behira governorate (Itay El-Baroud Agricultural Research Station) and Menoufia governorate during three successive growing seasons i.e. 2017/2018, 2018/2019 and 2019/2020. Results of the current study showed that 47 wheat genotypes were resistant and had the lowest values of final rust severity (FRS %), average coefficient of infection (ACI) and area under disease progress curve (AUDPC). Also, these genotypes showed desirable/acceptable relative resistance index (RRI) at the two locations during the three growing seasons of the study. Therefore, we can select these genotypes as resistant lines in the breeding program for the resistance of leaf rust.
EBELİK BÖLÜMÜ ÖĞRENCİLERİNİN MERHAMET DÜZEYLERİNİN BELİRLENMESİ
Authors: DOĞAN YÜKSEKOL Özlem , ORHAN İlksen , YILDIZ Erman , YILMAZ Ayşe Nur
Published: November 2020

Bu araştırma, ebelik bölümünde okuyan öğrencilerin merhamet düzeylerinin belirlenmesi amacıyla yapılmıştır. Tanımlayıcı olarak yapılan araştırmanın örneklemini Ebelik bölümü 1., 2., 3. ve 4. sınıfta okuyan 267 öğrenci oluşturmuştur. Verilerin toplanmasında Kişisel Bilgi Formu ve Merhamet Ölçeği (MÖ) kullanılmıştır. Verilerin analizinde yüzde, frekans hesaplamaları, Anova, t testi ve post-hoc analizleri kullanılmıştır. Araştırmaya katılan öğrencilerin yaş ortalamasının 21.08±1.98 olduğu, %98.1’inin bekâr olduğu, %60.3’ünün il merkezinde yaşadığı, %95.9’unun kendisini merhametli bulduğu belirlenmiştir. Öğrencilerin merhamet düzeyleri 101.64±12.41 olarak yüksek düzeyde saptanmıştır.
Load-Sharing Model under Lindley Distribution and Its Parameter Estimation Using the Expectation-Maximization Algorithm
Authors: Park Chanseok , Wang Min , Alotaibi Refah Mohammed , Rezk Hoda
Published: November 2020

A load-sharing system is defined as a parallel system whose load will be redistributed to its surviving components as each of the components fails in the system. Our focus is on making statistical inference of the parameters associated with the lifetime distribution of each component in the system. In this paper, we introduce a methodology which integrates the conventional procedure under the assumption of the load-sharing system being made up of fundamental hypothetical latent random variables. We then develop an expectation maximization algorithm for performing the maximum likelihood estimation of the system with Lindley-distributed component lifetimes. We adopt several standard simulation techniques to compare the performance of the proposed methodology with the Newton–Raphson-type algorithm for the maximum likelihood estimate of the parameter. Numerical results indicate that the proposed method is more effective by consistently reaching a global maximum.
Forecasting the Heat Load of Residential Buildings with Heat Metering Based on CEEMDAN-SVR
Authors: Gao Xiaoyu , Qi Chengying , Xue Guixiang , Song Jiancai , Zhang Yahui , Yu Shi-ang
Published: November 2020

The energy demand of the district heating system (DHS) occupies an important part in urban energy consumption, which has a great impact on the energy security and environmental protection of a city. With the gradual improvement of people’s economic conditions, different groups of people now have different demands for thermal energy for their comfort. Hence, heat metering has emerged as an imperative for billing purposes and sustainable management of energy consumption. Therefore, forecasting the heat load of buildings with heat metering on the demand side is an important management strategy for DHSs to meet end-users’ needs and maintain energy-saving regulations and safe operation. However, the non-linear and non-stationary characteristics of buildings’ heat load make it difficult to predict consumption patterns accurately, thereby limiting the capacity of the DHS to deliver on its statutory functions satisfactorily. A novel ensemble prediction model is proposed to resolve this problem, which integrates the advantages of Complete Ensemble Empirical Mode Decomposition with Adaptive Noise (CEEMDAN) and support vector regression (SVR), called CEEMDAN-SVR in this paper. The proposed CEEMDAN-SVR algorithm is designed to automatically decompose the intrinsic mode according to the characteristics of heat load data to ensure an accurate representation of heat load patterns on multiple time scales. It will also be useful for developing an accurate prediction model for the buildings’ heat load. In formulating the CEEMDAN-SVR model, the heat load data of three different buildings in Xingtai City were acquired during the heating season of 2019–2020 and employed to conduct detailed comparative analysis with modern algorithms, such as extreme tree regression (ETR), forest tree regression (FTR), gradient boosting regression (GBR), support vector regression (SVR, with linear, poly, radial basis function (RBF) kernel), multi-layer perception (MLP) and EMD-SVR. Experimental results reveal that the performance of the proposed CEEMDAN-SVR model is better than the existing modern algorithms and it is, therefore, more suitable for modeling heat load forecasting.
The Proximity Effect in Twin Line with Round Conductors Placed in Conductive Medium
Authors: Jabłoński Paweł , Kusiak Dariusz , Szczegielniak Tomasz , Piątek Zygmunt
Published: November 2020

Power lines are often placed in ground or sea water, which are weakly conductive media. In the paper, a new analytical formula, taking into account the proximity effect in a twin line placed in a weakly conductive medium, is derived, and the effect of the conductive medium is considered. In the first step, one of the wires is replaced by a current filament, and the solution is sought for magnetic vector potential around the filament. In the next step, an analytical formula for eddy currents induced in a long straight conductor of circular cross-section placed near to the current filament in the extensive conductive medium is found by using the method of separation of variables. The correctness of the formula is checked by comparison with the results obtained via other methods like finite and boundary element methods. Then, the effect of various parameters on the eddy current distribution is tested. Next, the proximity effect in a twin symmetrical line is considered, and the effect of the conductivity of the surrounding medium is investigated. The results indicate that the conductive medium weakens the proximity effect, but in typical cases (ground and sea water), the effect is very small.
Energy-Efficient Speed Profile Optimization and Sliding Mode Speed Tracking for Metros
Authors: Wang Xiaowen , Xiao Zhuang , Chen Mo , Sun Pengfei , Wang Qingyuan , Feng Xiaoyun
Published: November 2020

Nowadays, most metro vehicles are equipped with an automatic train operation (ATO) system, and the speed control method, combining cruise speed planning and proportional-integral-derivative (PID) control, is widely used. The automation is achieved, and the energy-efficient can be improved. This paper presents an improved artificial bee colony algorithm for speed profile optimization with coast mode and an adaptive terminal sliding mode method for speed tracking. Specifically, a multi-objective optimization model is established, which considers energy consumption, comfortableness, and punctuality. Then, a novel artificial bee colony algorithm named regional reinforcement artificial bee colony (RR-ABC) is designed, to search the optimal speed profile with coast mode, in which some improvements are made to speed up convergence and to avoid local optimal solutions. For speed-tracking control, the adaptive terminal sliding mode controller (ATSMC) is used to improve the speed error, robustness, and energy saving. In addition, a disturbance observer (DOB) is designed to improve the anti-interference ability of the system and further improve the robustness and anti-disturbance, which are also conducive to speed error and energy saving. Finally, the line and train data of the Qingdao Metro Line 6 are used for simulation, which proves the effectiveness of the study. Specific to the energy saving rate, and compared with normal algorithms, RR-ABC with coast mode is approximately 9.55%, and ATSMC+DOB is 7.58%.