bluuebunny/crossref_metadata_2025 huggingface dataset:
Resilient evacuation infrastructure; an assessment of resilience toward natural hazards
Authors: Fathianpour Azin , Babaeian Jelodar Mostafa , Wilkinson Suzanne , Evans Barry
Published: April 2023

Purpose

As evacuation is one of the most used response actions to such disasters, it is essential to understand correctly what a resilient evacuation would mean. One critical factor in evacuation resilience is the resilience level of evacuation infrastructures. Also, UN sustainable development has a goal to build resilient infrastructures. This study aims to investigate the characteristics of resilient evacuation infrastructures.

Design/methodology/approach

A systematic methodology for reviewing articles has been implemented to understand how vulnerable cities can be more prepared, especially for pedestrian evacuation.

Findings

This study has developed an evacuation scoring system framework for pedestrians to investigate evacuation infrastructure in terms of different resilience features, such as redundancy, safe-to-fail, readiness and capacity. The most practical evacuation system will be estimated. The output of this study can provide insight into a final output to provide the features of a successful pedestrian evacuation system for future policy drafting for infrastructure strategy decision-makers.

Practical implications

Climate change has made the risks of natural hazards such as tsunamis more intense for humans. Many people in the world live in hazardous environments and are susceptible to disasters. A community must be prepared to mitigate the destructive event and quickly respond to be called resilient.

Originality/value

This is an original work. The researcher has gone through a deep literature review and developed a cluster showing the features a resilient evacuation infrastructure should have.
Laser 3D tightly coupled mapping method based on visual information
Authors: Liu Sixing , Chai Yan , Yuan Rui , Miao Hong
Published: April 2023

Purpose

Simultaneous localization and map building (SLAM), as a state estimation problem, is a prerequisite for solving the problem of autonomous vehicle motion in unknown environments. Existing algorithms are based on laser or visual odometry; however, the lidar sensing range is small, the amount of data features is small, the camera is vulnerable to external conditions and the localization and map building cannot be performed stably and accurately using a single sensor. This paper aims to propose a laser three dimensions tightly coupled map building method that incorporates visual information, and uses laser point cloud information and image information to complement each other to improve the overall performance of the algorithm.

Design/methodology/approach

The visual feature points are first matched at the front end of the method, and the mismatched point pairs are removed using the bidirectional random sample consensus (RANSAC) algorithm. The laser point cloud is then used to obtain its depth information, while the two types of feature points are fed into the pose estimation module for a tightly coupled local bundle adjustment solution using a heuristic simulated annealing algorithm. Finally, the visual bag-of-words model is fused in the laser point cloud information to establish a threshold to construct a loopback framework to further reduce the cumulative drift error of the system over time.

Findings

Experiments on publicly available data sets show that the proposed method in this paper can match its real trajectory well. For various scenes, the map can be constructed by using the complementary laser and vision sensors, with high accuracy and robustness. At the same time, the method is verified in a real environment using an autonomous walking acquisition platform, and the system loaded with the method can run well for a long time and take into account the environmental adaptability of multiple scenes.

Originality/value

A multi-sensor data tight coupling method is proposed to fuse laser and vision information for optimal solution of the positional attitude. A bidirectional RANSAC algorithm is used for the removal of visual mismatched point pairs. Further, oriented fast and rotated brief feature points are used to build a bag-of-words model and construct a real-time loopback framework to reduce error accumulation. According to the experimental validation results, the accuracy and robustness of the single-sensor SLAM algorithm can be improved.
Investigating consumer ethical beliefs: role of moral philosophies and personality traits
Authors: Gala Prachi , Chauhan Rahul , King Robert , Vitell Scott
Published: April 2023

Purpose

This research looks at the main effect of individuals’ moral philosophies, idealism and relativism, and its impact on the four dimensions of the consumer ethics beliefs – active benefit, passive benefit, no harm and doing good. The moderating impact of two dominant personalities – Machiavellianism and narcissism – was also analyzed. Based on Hunt–Vitell theory of ethics, this study aims to propose that there is a positive and significant impact of more relativistic and less idealistic moral philosophies on the decreased consumer ethical perceptions and that the narcissistic/Machiavellian personality traits drive that effect.

Design/methodology/approach

A total of 497 survey respondents were recruited via an online platform. All respondents were asked to answer questions, which were divided into four major parts. The first part consisted of scales related to both moral philosophies, the second part had both dark personality scales, the third part questioned about their consumer ethical beliefs and the final part was related to consumer demographics.

Findings

Relativists had higher scores in three consumer unethical belief dimensions. Idealists were not supportive of the active and passive illegal activities, as did their positive relation with doing good aspect of the ethical beliefs. Machiavellians strengthen the positive relativism relationship. The idealistic relation of narcissists, compared to relativistic relation, is stronger on unethical decision-making for consumers.

Originality/value

This study contributes to the current knowledge of individual’s moral philosophies and their impact on consumer ethical beliefs. It further demonstrates how the dark personalities of narcissism and Machiavellianism drive the relationship.
The impact of institutional quality on country-level variations in foreign equity shares in transition economies
Authors: Krasniqi Besnik , Williams Nick , Hashi Iraj , Reçica Fisnik , Lubishtani Ermal , Kryeziu Liridon
Published: April 2023

Purpose

This paper aims to examine the influence of formal and informal institutional quality on country-level variations in foreign equity shares in transition economies (TEs).

Design/methodology/approach

Drawing on institutional theory and transaction cost theory, this paper examines the influence of formal and informal institutional quality on country-level variations in foreign equity shares in TEs. The authors use a two-step empirical strategy, identifying clusters of explanatory variables and running generalized least squares random effect estimations to test for the influence of explanatory and control variables on foreign equity shares.

Findings

Foreign equity share is positively affected by informal institutions and negatively by formal institutions. However, when control for stage of transition we find that the the presence of informal institutions in more rapidly or advanced transforming economies negatively influences foreign equity shares. Complex infrastructure discourages foreign equity shareholdings, and foreign companies use informal practices to overcome unfavourable host country conditions. Government size has a negative effect, and gross domestic product per capita positively affects foreign equity shares.

Research limitations/implications

The study is the new groundwork for the re-enactment of a fruitful discussion on foreign equity. The study has practical implications for managers, too – managers of foreign-owned firms operating in weakly installed institutional environments should carefully analyse the entry strategies because of the high presence of informal institutions. Furthermore, managers could understand the various facilitation roles of informal institutions in any firm internationalisation effort to arrive at optimal ownership holdings for better internationalisation performance. Although the study is based on a sample of transition countries, the findings have implications for other emerging economies’ contexts sharing similar institutional settings.

Originality/value

This study provides a unique empirical investigation and evidence based on country-level indicators on the effect of formal and informal institutions on foreign equity shares holdings in TEs, reinforcing the importance of impacts of both the formal and informal dimensions on ownership decisions of foreign investors.
Palmoplantar pustulosis and pustulotic arthro‐osteitis associated with multiple venous occlusion: A case report and literature review
Authors: Inoue Emi , Hiroumi Shiori , Sato Sachina , Hayashi Misa , Konaka Hachiro , Tsuji Shigeyoshi , Higashiyama Mari
Published: April 2023

Pustulotic arthro‐osteitis (PAO) is a rare chronic inflammatory arthropathy associated with palmoplantar pustulosis. The pathogenesis of PAO remains unclear. The most common musculoskeletal involvement in PAO is ossification of the sternoclavicular joints. A combination of parietal inflammation and hyperostosis‐induced mechanical compression in this region is hypothesized to contribute to multiple venous thrombosis. Here, we present a 66‐year‐old man with PAO‐associated multiple venous occlusion who was successfully treated with guselkumab. We also discuss its clinical manifestation and cause by reviewing the literature.
A review on the use of steerable sheaths in complex endovascular aortic repair
Authors: Tam Jacky Siu Chung , Cheng Stephen Wing Keung
Published: April 2023

Complex aortic aneurysms are now more commonly treated endovascularly, and often require a fenestrated‐branched endovascular aneurysm repair. The use of steerable sheaths can improve the technical success rate in catheterisation of target visceral vessels and reduce the surgical risks associated with these complicated procedures. There are several commercially available steerable sheaths in the market, but similar devices can be homemade using different endovascular instruments. Steerable sheaths allow catheterisation of downward orientated branches more easily through a transfemoral approach. The risks associated with a traditional upper extremity access can be minimalised. They are also described in the use of several other situations during endovascular aortic repairs. Limitations to this technique are the availability of the device, the stability of the sheath curvature, the difficulty to deliver instruments in a tight curve and the associated complications if large sheaths are used. Steerable sheaths can be used as a primary intent when challenging anatomy is anticipated or as an adjunct when standard procedures are not successful.
Treatment patterns and outcomes in adolescents and young adults with nodular lymphocyte‐predominant Hodgkin lymphoma: an IMPACT cohort study
Authors: Punnett Angela , Baxter Nancy N. , Hodgson David , Sutradhar Rinku , Pole Jason D. , Lau Cindy , Nathan Paul C. , Gupta Sumit
Published: April 2023

We leveraged population‐based clinical and healthcare data to identify treatment patterns and long‐term outcomes among adolescents and young adults (AYA) with nodular lymphocyte‐predominant Hodgkin lymphoma (NLPHL). All Ontario, Canada, AYA aged 15–21 years at diagnosis with NLPHL between 1992 and 2012 were identified, and their detailed clinical data were collected. Linkage to healthcare databases identified additional events (subsequent malignant neoplasms [SMN], relapses and deaths). Event‐free survival (EFS) and overall survival (OS) were compared by locus of care (adult vs. paediatric) and predictors of outcomes determined. Of 1014 AYA with Hodgkin lymphoma, 54 (5.3%) had NLPHL; 15 (27.8%) were treated at a paediatric centre. No paediatric centre patient received radiation only versus 16 (41.0%) of adult centre patients. Excision only was more common in paediatric centres (p < 0.001). The 20‐year EFS and OS rates were 82.9% ± 5.2% and 100% respectively. Advanced stage (hazard ratio: 4.9, 95% CI: 1.3–18.4; p = 0.02) was associated with inferior EFS. Although the 25‐year cumulative incidence of SMN was 19.3% ± 9.6% for the entire cohort, there were no SMN among the patients treated with excision only. AYA with NLPHL have outstanding long‐term survival. Resection alone was rare outside of paediatric institutions but associated with excellent outcomes. Given substantial SMN risks, chemotherapy‐sparing and radiation‐sparing strategies for appropriate subsets of patients are warranted.
More is Better: English Language Statistics are Biased Toward Addition
Authors: Winter Bodo , Fischer Martin H. , Scheepers Christoph , Myachykov Andriy
Published: April 2023

We have evolved to become who we are, at least in part, due to our general drive to create new things and ideas. When seeking to improve our creations, ideas, or situations, we systematically overlook opportunities to perform subtractive changes. For example, when tasked with giving feedback on an academic paper, reviewers will tend to suggest additional explanations and analyses rather than delete existing ones. Here, we show that this addition bias is systematically reflected in English language statistics along several distinct dimensions. First, we show that words associated with an increase in quantity or number (e.g.,add, addition, more, most) are more frequent than words associated with a decrease in quantity or number (e.g.,subtract, subtraction, less, least). Second, we show that in binomial expressions, addition‐related words are mentioned first, that is,add and subtractrather thansubtract and add. Third, we show that the distributional semantics of verbs of change, such asto improveandto transform, overlap more with the distributional semantics ofadd/increasethansubtract/decrease, which suggests that change verbs are implicitly biased toward addition. Fourth, addition‐related words have more positive connotations than subtraction‐related words. Fifth, we demonstrate that state‐of‐the‐art large language models, such as the Generative Pre‐trained Transformer (GPT‐3), are also biased toward addition. We discuss the implications of our results for research on cognitive biases and decision‐making.
State of forgiveness: Cooperation, conciliation, and state formation in Mughal South Asia (1556–1707)
Authors: Morshed Safya
Published: April 2023

This paper contributes to a growing literature on state capacity with reference to the early modern Asian empires. The historiography of these states, and especially the Mughal empire of South Asia, has moved away from an image of unrestrained despotism towards that of a constrained state, but has yet to explore fully what these constraints were and what the state did to overcome them. Using a new dataset on conflicts in Mughal South Asia, and an analytical model, the paper shows how forgiving rebel leaders was used as a strategic tool to secure stability, in a setting where high information costs made intermediaries indispensable to the state. The paper also offers some comparison between Asian empires on the role of intermediaries in shaping state constraint and fiscal policies.
Separating N2O production and consumption in intact agricultural soil cores at different moisture contents and depths
Authors: Button Erik S. , Marsden Karina A. , Nightingale Philip D. , Dixon Elizabeth R. , Chadwick David R. , Jones David L. , Cárdenas Laura M.
Published: April 2023

Agricultural soils are a major source of the potent greenhouse gas and ozone depleting substance, N2O. To implement management practices that minimize microbial N2O production and maximize its consumption (i.e., complete denitrification), we must understand the interplay between simultaneously occurring biological and physical processes, especially how this changes with soil depth. Meaningfully disentangling of these processes is challenging and typical N2O flux measurement techniques provide little insight into subsurface mechanisms. In addition, denitrification studies are often conducted on sieved soil in altered O2 environments which relate poorly to in situ field conditions. Here, we developed a novel incubation system with headspaces both above and below the soil cores and field‐relevant O2 concentrations to better represent in situ conditions. We incubated intact sandy clay loam textured agricultural topsoil (0–10 cm) and subsoil (50–60 cm) cores for 3–4 days at 50% and 70% water‐filled pore space, respectively. 15N‐N2O pool dilution and an SF6 tracer were injected below the cores to determine the relative diffusivity and the net N2O emission and gross N2O emission and consumption fluxes. The relationship between calculated fluxes from the below and above soil core headspaces confirmed that the system performed well. Relative diffusivity did not vary with depth, likely due to the preservation of preferential flow pathways in the intact cores. Gross N2O emission and uptake also did not differ with depth but were higher in the drier cores, contrary to expectation. We speculate this was due to aerobic denitrification being the primary N2O consuming process and simultaneously occurring denitrification and nitrification both producing N2O in the drier cores. We provide further evidence of substantial N2O consumption in drier soil but without net negative N2O emissions. The results from this study are important for the future application of the 15N‐N2O pool dilution method and N budgeting and modelling, as required for improving management to minimize N2O losses.
The hygienic aspects in the management of strangles
Authors: Fridberg Alberte , Adler Ditte Marie Top , Jørgensen Marianne Green , Olsen Rikke Heidemann
Published: April 2023

Streptococcus equi subsp. equi (S. equi) is a frequently encountered pathogen in equine practice. S. equi causes infection of the upper airways of horses, a condition known as strangles. Strangles is a highly contagious disease and may be economically devastating as well. Difficulties in the eradication of the disease using vaccines and medical treatments make hygienic measures crucial in order to limit transmission of the pathogen during outbreaks. This review aims to elucidate the challenges in handling an outbreak of strangles as well as develop a basic plan on how such an outbreak is handled in a hygienically optimal fashion. The results of this review suggest a longer environmental survival time of S. equi than previously assumed and support the importance of modification of surfaces for proper disinfection with appropriate disinfectants. Furthermore, the efficiency of using a colour‐coding system in dividing healthy, exposed and clinically affected horses is discussed. Individual temperature monitoring twice daily is recommended for the identification of diseased horses before they pose a contagious risk. Additionally, changing clothes between visiting different stable units is likewise recommended, to minimise transmission of disease. In conclusion, veterinarians, personnel and horse owners at equestrian centres need to be aware of the importance of isolation, monitoring and dividing the site into zones according to the risk of infection. Finally, it can be concluded that regardless of size, practical biosecurity measures can be implemented within all equine facilities.
Initial Characterisation ofSK01Sanidine: A Candidate40Ar/39ArReference Material
Authors: Li Youjuan , Jicha Brian R. , Zhang Wanfeng , Chen Wen , Singer Brad S. , Zheng Dewen , He Huaiyu
Published: April 2023

The precision and accuracy of40Ar/39Ar dates are ultimately linked to co‐irradiated reference materials of known age. Here we provide new data from the SK01 sanidine, which was analysed in three different laboratories to evaluate it as a40Ar/39Ar reference material. Aliquots of 5 mg, incrementally heated in two laboratories, yielded indistinguishable results with a weighted mean age of 27.58 ± 0.06 Ma (95% confidence level). Single‐crystal step heating and single‐crystal total fusion analyses of SK01 sanidine were undertaken in the third laboratory to further test the intracrystalline homogeneity. For the seven step‐heating analyses, six crystals yielded nearly concordant age spectra with40Ar/39Ar ages ranging from 26.853 ± 0.094 Ma to 26.963 ± 0.067 Ma, whereas one crystal gave an older age of 27.774 ± 0.071 Ma with a slightly discordant age spectrum. Twenty‐three single‐crystal total fusion analyses yielded40Ar/39Ar ages ranging from 27.070 ± 0.108 Ma to 27.736 ± 0.062 Ma with a dispersion of ~ 3.8%. The older ages from single‐crystal total fusion dates are interpreted to reflect an inherited or excess argon component in some crystals. This is an initial characterisation of the SK01 sanidine, and additional work needs to be conducted to further evaluate the age dispersion so that it can be utilised as a40Ar/39Ar reference material.
Helicobacter pylori bacteremia presenting as seizure and unconsciousness: The brief case
Authors: Yu Hang , Li Jing , Liu Xueke , Chen Zhen , Li Dongrong , Wei Yao
Published: April 2023

Background

Helicobacter pylori bacteremia is rare and difficult to make a definite diagnosis.

Case Presentation

This is a 40‐year‐old woman represented as fever and unconsciousness accompanied by tics. She was diagnosed as Helicobacter pylori bacteremia and received emergency endotracheal intubation and antibiotics. Her symptoms resolved and she was discharged from ICU at the sixth day.

Conclusions

Helicobacter pylori bacteremia is rare and hard to identify. Varied clinical manifestations leading to more difficult to make a definite diagnosis.
Supporting Families Facing Lactation Anaphylaxis: A Case Report
Authors: Knutson Julie , Youssef Alicia
Published: April 2023

Lactation anaphylaxis is a rare condition that may occur consequent to breastfeeding. Early identification and management of symptoms is paramount to the physical well‐being of the birthing person. Supporting newborn feeding goals is also a key component of care. In cases in which the birthing person wants to exclusively feed human milk, planning should include streamlined access to donor milk. Clear communication between health care providers and developing systems to access donor milk for parental indications may help address barriers.
CUT ABOVE THE REST: A MULTI‐DISCIPLINARY STUDY OF TWO SLATE KNIVES FROM FORAGER CONTEXTS IN COASTAL NORWAY
Authors: Lentfer Carol , Skandfer Marianne , Presslee Sam , Hagan Richard , Robson Harry K. , Damm Charlotte
Published: April 2023

Slate was a prominent tool material in the Scandinavian Stone Age. However, details of tool function have relied on morphology and have added little to our understanding of their role in hunting and processing. Here, we demonstrate that it is possible to identify both the use‐wear traces and residues from slate knives from northern Norway. By applying a multi‐disciplinary approach incorporating experimentation, use‐wear and organic residue analyses, we identified residues, including seal hair, and use‐traces which indicate the tools were used to process fresh marine mammals.
Grand challenges, corporate legitimacy, and community integration: an integrative smart technology model
Authors: Kummitha Rama Krishna Reddy
Published: April 2023

By referring to the smart city industry, this research studies how commercial firms gain legitimacy when their products aim to address grand challenges. Despite the reputation of giant technology companies and the overall legitimacy they enjoy in technology markets, exploiting opportunities in social contexts connected to grand challenges requires a societal‐oriented approach. Firms that engaged in smart cities initially approached cities with a business‐as‐usual approach, to be met with sharp criticism from local communities and pressure groups. In response, firms had to redraw their strategies to include communities in the process to stay close to local reality. This paper theorizes the process and highlights an Integrative Smart Technology Model (ISTM) to narrate how firms strategically include communities in the planning process and gain legitimacy for the technologies.
Equilibrium Violation From the Complex Stiffness
Authors: Makris Nicos
Published: April 2023

Evidence from cyclic tests on metals, elastomers, and sandy soils reveals that damping forces are nearly rate-independent and structural (hysteretic or rate-independent) damping was widely adopted since the 1940s. While there is no time-domain constitutive equation for a linear spring connected in parallel with a rate-independent dashpot, the dynamic stiffness (transfer function) of this mechanical network can be constructed in the frequency domain; and it was known since the early 1960s that this mechanical network exhibits a non-causal response. In view of its simplicity in association with the wide practical need to model rate-independent dissipation, this mechanical network was also implemented in time-domain formulations with the label complex stiffness where the force output, P(t) is related in the time domain to the displacement input, u(t), with P(t) = k(1 + iη)u(t). This paper shows that the complex stiffness, as expressed in the time domain by various scholars, is a fundamentally flawed construct since in addition to causality it violates equilibrium.
An IL-6/STAT3/MR/FGF21 axis mediates heart-liver cross-talk after myocardial infarction
Authors: Sun Jian-Yong , Du Lin-Juan , Shi Xue-Rui , Zhang Yu-Yao , Liu Yuan , Wang Yong-Li , Chen Bo-Yan , Liu Ting , Zhu Hong , Liu Yan , Ruan Cheng-Chao , Gan Zhenji , Ying Hao , Yin Zhinan , Gao Ping-Jin , Yan Xiaoxiang , Li Ruo-Gu , Duan Sheng-Zhong
Published: April 2023

The liver plays a protective role in myocardial infarction (MI). However, very little is known about the mechanisms. Here, we identify mineralocorticoid receptor (MR) as a pivotal nexus that conveys communications between the liver and the heart during MI. Hepatocyte
MR
deficiency and MR antagonist spironolactone both improve cardiac repair after MI through regulation on hepatic fibroblast growth factor 21 (FGF21), illustrating an MR/FGF21 axis that underlies the liver-to-heart protection against MI. In addition, an upstreaming acute interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) pathway transmits the heart-to-liver signal to suppress MR expression after MI. Hepatocyte
Il6
receptor deficiency and
Stat3
deficiency both aggravate cardiac injury through their regulation on the MR/FGF21 axis. Therefore, we have unveiled an IL-6/STAT3/MR/FGF21 signaling axis that mediates heart-liver cross-talk during MI. Targeting the signaling axis and the cross-talk could provide new strategies to treat MI and heart failure.
Evaluation of the Interactions between Mumps Virus and Guinea Pig
Authors: Lang Balija Maja , Štimac Adela , Košutić Gulija Tanja , Gudan Kurilj Andrea , Bekavac Ana , Plećaš Ante , Halassy Beata , Jagušić Maja , Forčić Dubravko
Published: April 2023

Understanding of mumps virus (MuV) pathogenesis and the immune responses against MuV infection is limited. One of the reasons is the lack of relevant animal models.
Penicillin Binding Protein Substitutions Cooccur with Fluoroquinolone Resistance in Epidemic Lineages of Multidrug-Resistant Clostridioides difficile
Authors: Dingle Kate E. , Freeman Jane , Didelot Xavier , Quan T. Phuong , Eyre David W. , Swann Jeremy , Spittal William D. , Clark Emma V. , Jolley Keith A. , Walker A. Sarah , Wilcox Mark H. , Crook Derrick W.
Published: April 2023

Fluoroquinolone and cephalosporin use in healthcare settings has triggered outbreaks of high-mortality, multidrug-resistant
C. difficile
infection. Here, we identify a mechanism associated with raised cephalosporin MICs in
C. difficile
comprising amino acid substitutions in two cell wall transpeptidase enzymes (penicillin binding proteins).
Draft Genome Sequence of Zhouia amylolytica CL16, Isolated from Mangrove Soil
Authors: Hong Clarine Wan Ling , Liew Kok Jun , Lam Ming Quan , Chong Chun Shiong
Published: April 2023

Zhouia amylolytica
CL16 was isolated from the mangrove soil of Tanjung Piai, Malaysia. The present work reports the draft genome sequence of this bacterium. The genome consists of 113 glycoside hydrolases, 40 glycosyltransferases, 4 polysaccharide lyases, 23 carbohydrate esterases, 5 auxiliary activities, and 27 carbohydrate-binding modules, which warrant further investigation.
Association between Pregestational Vaginal Dysbiosis and Incident Hypertensive Disorders of Pregnancy Risk: a Nested Case-Control Study
Authors: Li Xiao , Tian Zhaomei , Cui Ran , Lv Jiale , Yang Xin , Qin Lang , Liu Zheng , Zhang Changlong , Jin Congcong , Xu Yanqi , Chen Zi-Jiang , Zhao Han , Zhao Shigang
Published: April 2023

The etiology of HDP remains unclear to date. Effective methods for the individualized prediction and prevention are lacking.
Experimental investigation of suddenly expanded flow at sonic and supersonic Mach numbers using semi-circular ribs: a comparative study between experimental, single layer, deep neural network (SLNN and DNN) models
Authors: Khan Ambareen , Rajendran Parvathy , Sidhu Junior Sarjit Singh , Sharifpur Mohsen
Published: April 2023

In this work, we present the findings of the experimental study conducted in a rectangular duct at sonic and supersonic Mach numbers using passive control in the form of semi-circular ribs. Tests are conducted at sonic Mach number and four supersonic Mach numbers. The supersonic Mach numbers of the study are 1.5, 1.8, 2.2, and 2.5. The flow from the nozzles is discharged into the enlarged duct. The ribs are placed at 28 mm (1D), 56 mm (2D), 84 mm (3D), and 112 mm (4D) from the base to find the effect of the control mechanism on the flow field and the base pressure. The ribs of 6, 8, and 10 mm diameter are used to control the base pressure and ultimately the base drag. At Mach 2.2 and 2.5, control is not effective because the nozzles are over-expanded. These results reiterate the findings from the literature that the control is effective whether passive or active when nozzles flow under the influence of a favorable pressure gradient. The same is evident from the results at Mach 1.5 and 1.8. The NPRs at these Mach numbers are such that nozzles are under, correctly, and under expanded. When nozzles are operated for under expanded case, the control results in an increase in the base pressure when passive control is employed. These highly complex data are predicted using a single-layered neural network and a deep-layer neural network to save time and make it cost-effective, which shows that the data can be predicted with an accuracy of 0.88–0.99. The proposed models can predict the highly sensitive pressure terms for aerodynamic flows.
Noise Reduction Method of Pipeline Infrasonic Leakage Signal Based on Improved Prony Algorithm and Difference Energy Model
Authors: Li Min , Hao Yongmei , Xing Zhixiang , Yao Qiang , Ning Xu
Published: April 2023

To solve the difficult problem of low-frequency noise processing in pipeline infrasonic leakage detection signals, a pipeline infrasonic leakage signal denoising method based on improved Prony algorithm and differential energy model was proposed to reduce the low-frequency interference noise in the signal and to improve the signal denoising effect. First, the frequency window of the effective signal is obtained according to the spectrogram of the infrasound signal. Aiming at the problem that the Prony algorithm is affected by noise, a difference energy model is proposed. The difference energy model is used to filter out the part of the frequency domain signal with large energy fluctuation, and a relatively stable preprocessing signal is obtained. In view of the instability of the traditional Prony algorithm, a Hankel matrix is established in the operation process. The stability is improved by extracting the extremum and residue of the signal instead of directly solving the sampling data points, and the extremum and residue of the effective signal are selected by combining the frequency window of the active ingredient. Finally, the effective signal is reconstructed to obtain a relatively stable infrasound leakage noise reduction signal. Experimental results show that the noise reduction technology based on the improved Prony algorithm and differential energy model can effectively reduce the noise of pipeline leakage signals. Compared with the traditional Prony algorithm, the noise reduction effect of the proposed method is up to 38.01% higher. Compared with the empirical mode decomposition method, the noise reduction effect of this method is improved by 9.25% at least, which opens up a new idea for pipeline leakage signal noise reduction.
Inherent Complexity and Early Warning of Zaozhuang Circular Economy System
Authors: Ma Junhai , Wang Dexia , Li Xiao , Zhang Bing
Published: April 2023

Based on China’s green energy development strategy, this paper constructs a basic model of recycling and a channel expansion model for the circular economy foundation of Zaozhuang, Shandong Province, China. Through numerical simulation, it is found that each member of the supply chain should control the rate of price adjustment, otherwise it will cause market disruption. The model is controlled based on a chaos control method. Then, based on the fuzzy comprehensive evaluation method, an early warning system for the circular economy of Zaozhuang City is constructed. It is found that the economic development of Zaozhuang is a serious warning, resources are moderate warning, and the environment is not in an alarm state. In addition to paying attention to energy conservation and emission reduction of enterprises, the government should pay attention to creating awareness of energy conservation and emission reduction in society, and strengthen the technological investment in reducing pollutant emissions. This paper provides a strategic reference for the circular economy model in Zaozhuang, Shandong, China.
Classification on Boundary-Equilibria and Singular Continuums of Continuous Piecewise Linear Systems
Authors: Chen Hebai , Feng Zhaosheng , Yang Hao , Zhou Linfeng
Published: April 2023

In this paper, we show that any switching hypersurface of [Formula: see text]-dimensional continuous piecewise linear systems is an [Formula: see text]-dimensional hyperplane. For two-dimensional continuous piecewise linear systems, we present local phase portraits and indices near the boundary equilibria (i.e. equilibria at the switching line) and singular continuum (i.e. continuum of nonisolated equilibria) between two parallel switching lines. The index of singular continuum is defined. Then we show that boundary-equilibria and singular continuums can appear with many parallel switching lines.
IMPACT OF VARIABLE SLIP AND WALL PROPERTIES ON PERISTALTIC FLOW OF EYRING–POWELL FLUID THROUGH INCLINED CHANNEL: ARTIFICIAL INTELLIGENCE BASED PERTURBATION TECHNIQUE
Authors: BOUJELBENE MOHAMED , HADIMANI BALACHANDRA , CHOUDHARI RAJASHEKHAR , SANIL PRATHIKSHA , GUDEKOTE MANJUNATHA , VAIDYA HANUMESH , PRASAD KEREHALLI VINAYAKA , FADHL BANDAR M. , MAKHDOUM BASIM M. , KHAN M. IJAZ , EL DIN SAYED M.
Published: April 2023

This paper emphasizes a new attempt at the peristaltic transport of Eyring–Powell fluid through a uniform channel. The analysis is performed in the presence of wall properties under the influence of variable liquid properties, the flow problem is mathematically developed. The channel walls are subjected to velocity and thermal slip conditions with long-wavelength and low Reynolds number approximations employed in the study. The governed nonlinear partial differential equations are normalized by using relevant nondimensional parameters and the solutions are obtained with the help of a regular perturbation technique. The effects of physical parameters of interest such as velocity, temperature, concentration, and streamlines are represented graphically. The investigations reveal that the material parameters and elastic parameters of the Eyring–Powell fluid model play a significant role by affecting the velocity and temperature profiles.
Table S2 from TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian Cancer
Authors: Lecker Laura S.M. , Berlato Chiara , Maniati Eleni , Delaine-Smith Robin , Pearce Oliver M.T. , Heath Owen , Nichols Samuel J. , Trevisan Caterina , Novak Marian , McDermott Jacqueline , Brenton James D. , Cutillas Pedro R. , Rajeeve Vinothini , Hennino Ana , Drapkin Ronny , Loessner Daniela , Balkwill Frances R.
Published: April 2023

CIBERSORT results of the TGFBI high/low samples in the TCGA and ICGC datasets
Table S1 from TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian Cancer
Authors: Lecker Laura S.M. , Berlato Chiara , Maniati Eleni , Delaine-Smith Robin , Pearce Oliver M.T. , Heath Owen , Nichols Samuel J. , Trevisan Caterina , Novak Marian , McDermott Jacqueline , Brenton James D. , Cutillas Pedro R. , Rajeeve Vinothini , Hennino Ana , Drapkin Ronny , Loessner Daniela , Balkwill Frances R.
Published: April 2023

List of antibodies used for flow cytometry
Table S1 S2 S3 legend from TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian Cancer
Authors: Lecker Laura S.M. , Berlato Chiara , Maniati Eleni , Delaine-Smith Robin , Pearce Oliver M.T. , Heath Owen , Nichols Samuel J. , Trevisan Caterina , Novak Marian , McDermott Jacqueline , Brenton James D. , Cutillas Pedro R. , Rajeeve Vinothini , Hennino Ana , Drapkin Ronny , Loessner Daniela , Balkwill Frances R.
Published: April 2023

Legend of supplementary tables
Figure S3 from TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian Cancer
Authors: Lecker Laura S.M. , Berlato Chiara , Maniati Eleni , Delaine-Smith Robin , Pearce Oliver M.T. , Heath Owen , Nichols Samuel J. , Trevisan Caterina , Novak Marian , McDermott Jacqueline , Brenton James D. , Cutillas Pedro R. , Rajeeve Vinothini , Hennino Ana , Drapkin Ronny , Loessner Daniela , Balkwill Frances R.
Published: April 2023

Effect of anti-TGFBI treatment in the HGS2 model
Supplementary Table 1 from Combinatorial CRISPR/Cas9 Screening Reveals Epistatic Networks of Interacting Tumor Suppressor Genes and Therapeutic Targets in Human Breast Cancer
Authors: Zhao Xiaoyu , Li Jinyu , Liu Zhimin , Powers Scott
Published: April 2023

This table lists 52 TSG names, TSG sgRNA sequences, all the oncogenic interactions in vivo, full PIK3CA network, co-occurrence analysis and the epistatic expression of CDK4, DNMT1 and SPRK1in breast cancer patients
Table S1 from A PLCB1–PI3K–AKT Signaling Axis Activates EMT to Promote Cholangiocarcinoma Progression
Authors: Liang Shuhang , Guo Hongrui , Ma Kun , Li Xianying , Wu Dehai , Wang Yiqi , Wang Wei , Zhang Shugeng , Cui Yifeng , Liu Yufeng , Sun Linmao , Zhang Bo , Xin Mengyang , Zhang Ning , Zhou Huanran , Liu Yao , Wang Jiabei , Liu Lianxin
Published: April 2023

Clinical characteristics of 60 CCA patients depending on PLCB1 expression levels
Supplementary methods from A PLCB1–PI3K–AKT Signaling Axis Activates EMT to Promote Cholangiocarcinoma Progression
Authors: Liang Shuhang , Guo Hongrui , Ma Kun , Li Xianying , Wu Dehai , Wang Yiqi , Wang Wei , Zhang Shugeng , Cui Yifeng , Liu Yufeng , Sun Linmao , Zhang Bo , Xin Mengyang , Zhang Ning , Zhou Huanran , Liu Yao , Wang Jiabei , Liu Lianxin
Published: April 2023

Supplementary methods
Supplementary Materials from Hyperpolarized Carbon-13 MRI for Early Response Assessment of Neoadjuvant Chemotherapy in Breast Cancer Patients
Authors: Woitek Ramona , McLean Mary A. , Ursprung Stephan , Rueda Oscar M. , Manzano Garcia Raquel , Locke Matthew J. , Beer Lucian , Baxter Gabrielle , Rundo Leonardo , Provenzano Elena , Kaggie Joshua , Patterson Andrew , Frary Amy , Field-Rayner Johanna , Papalouka Vasiliki , Kane Justine , Benjamin Arnold J.V. , Gill Andrew B. , Priest Andrew N. , Lewis David Y. , Russell Roslin , Grimmer Ashley , White Brian , Latimer-Bowman Beth , Patterson Ilse , Schiller Amy , Carmo Bruno , Slough Rhys , Lanz Titus , Wason James , Schulte Rolf F. , Chin Suet-Feung , Graves Martin J. , Gilbert Fiona J. , Abraham Jean E. , Caldas Carlos , Brindle Kevin M. , Sala Evis , Gallagher Ferdia A.
Published: April 2023

Supplementary Materials (clean)
Figure S6 from Specific Activation of the CD271 Intracellular Domain in Combination with Chemotherapy or Targeted Therapy Inhibits Melanoma Progression
Authors: Saltari Annalisa , Dzung Andreas , Quadri Marika , Tiso Natascia , Facchinello Nicola , Hernández-Barranco Alberto , Garcia-Silva Susana , Nogués Laura , Stoffel Corinne Isabelle , Cheng Phil F. , Turko Patrick , Eichhoff Ossia M. , Truzzi Francesca , Marconi Alessandra , Pincelli Carlo , Peinado Héctor , Dummer Reinhard , Levesque Mitchell P.
Published: April 2023

CD271 silencing reduces AÎ²(25-35) killing effect.
Data from TLE3 Sustains Luminal Breast Cancer Lineage Fidelity to Suppress Metastasis
Authors: Anstine Lindsey J. , Majmudar Parth R. , Aponte Amy , Singh Salendra , Zhao Ran , Weber-Bonk Kristen L. , Abdul-Karim Fadi W. , Valentine Mitchell , Seachrist Darcie D. , Grennel-Nickelson Katelyn E. , Cuellar-Vite Leslie , Sizemore Gina M. , Sizemore Steven T. , Webb Bryan M. , Thompson Cheryl L. , Keri Ruth A.
Published: April 2023

Abstract
Breast cancer subtypes and their phenotypes parallel different stages of the mammary epithelial cell developmental hierarchy. Discovering mechanisms that control lineage identity could provide novel avenues for mitigating disease progression. Here we report that the transcriptional corepressor TLE3 is a guardian of luminal cell fate in breast cancer and operates independently of the estrogen receptor. In luminal breast cancer, TLE3 actively repressed the gene-expression signature associated with highly aggressive basal-like breast cancers (BLBC). Moreover, maintenance of the luminal lineage depended on the appropriate localization of TLE3 to its transcriptional targets, a process mediated by interactions with FOXA1. By repressing genes that drive BLBC phenotypes, including SOX9 and TGFβ2, TLE3 prevented the acquisition of a hybrid epithelial–mesenchymal state and reduced metastatic capacity and aggressive cellular behaviors. These results establish TLE3 as an essential transcriptional repressor that sustains the more differentiated and less metastatic nature of luminal breast cancers. Approaches to induce TLE3 expression could promote the acquisition of less aggressive, more treatable disease states to extend patient survival.
Significance:
Transcriptional corepressor TLE3 actively suppresses SOX9 and TGFβ transcriptional programs to sustain the luminal lineage identity of breast cancer cells and to inhibit metastatic progression.
Data from AMPK Phosphorylates ZDHHC13 to Increase MC1R Activity and Suppress Melanomagenesis
Authors: Sun Yu , Li Xin , Yin Chengqian , Zhang Judy , Liang Ershang , Wu Xianfang , Ni Ying , Arbesman Joshua , Goding Colin R. , Chen Shuyang
Published: April 2023

Abstract
Inherited genetic variations in the melanocortin-1 receptor (MC1R) responsible for human red hair color (RHC) variants are associated with impaired DNA damage repair and increased melanoma risk. MC1R signaling is critically dependent on palmitoylation, primarily mediated by the protein acyltransferase zinc finger DHHC-type palmitoyltransferase 13 (ZDHHC13). A better understanding of how ZDHHC13 is physiologically activated could help identify approaches to prevent melanomagenesis in redheads. Here, we report that AMP-activated protein kinase (AMPK) phosphorylates ZDHHC13 at S208 to strengthen the interaction between ZDHHC13 and MC1R-RHC, leading to enhanced MC1R palmitoylation in redheads. Consequently, phosphorylation of ZDHHC13 by AMPK increased MC1R-RHC downstream signaling. AMPK activation and MC1R palmitoylation repressed UVB-induced transformation of human melanocytes in vitro and delayed melanomagenesis in vivo in C57BL/6J-MC1R-RHC mice. The importance of AMPK to MC1R signaling was validated in human melanomas where AMPK upregulation correlated with expression of factors downstream from MC1R signaling and with prolonged patient survival. These findings suggest AMPK activation as a promising strategy to reduce melanoma risk, especially for individuals with red hair.
Significance:
Phosphorylation of ZDHHC13 by AMPK at S208 promotes MC1R activation and suppresses melanocyte transformation, indicating activation of AMPK as a potential approach to prevent melanoma in people with red hair.
Supplementary Figure 2 from Biological Characterization of TAK-901, an Investigational, Novel, Multitargeted Aurora B Kinase Inhibitor
Authors: Farrell Pamela , Shi Lihong , Matuszkiewicz Jennifer , Balakrishna Deepika , Hoshino Takashi , Zhang Lilly , Elliott Sarah , Fabrey Robyn , Lee Bumsup , Halkowycz Petro , Sang BiChing , Ishino Seigo , Nomura Toshiyuki , Teratani Mika , Ohta Yoshikazu , Grimshaw Charles , Paraselli Bheema , Satou Takashi , de Jong Ron
Published: April 2023

PDF file - 1.5 MB, TAK-901 is not a potent inhibitor of cellular JAK2, c-SRC or ABL. Inhibition of various cellular tyrosine kinases by TAK-901. The indicated cells were treated with various concentrations of TAK-901, DMSO or control (Ctrl) compounds for 4 hours and then were lysed. Gel electrophoresis was performed followed by immunoblotting using the antibodies indicated.
Supplementary Figure 5 from UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo
Authors: Christoph Sandra , DeRyckere Deborah , Schlegel Jennifer , Frazer J. Kimble , Batchelor Lance A. , Trakhimets Alesia Y. , Sather Susan , Hunter Debra M. , Cummings Christopher T. , Liu Jing , Yang Chao , Kireev Dmitri , Simpson Catherine , Norris-Drouin Jacqueline , Hull-Ryde Emily A. , Janzen William P. , Johnson Gary L. , Wang Xiaodong , Frye Stephen V. , Earp H. Shelton , Graham Douglas K.
Published: April 2023

PDF - 634KB, Eighteen fish (Myc1-Myc18) were treated with UNC569 for 2 weeks. Animals were imaged pre- and post-treatment, with GFP intensities quantified as described in the text. Ten of 18 fish (55.6%; Myc1-Myc8, Myc10, Myc16) showed >50% regressions. Six fish (33.3%; Myc9, Myc11-15) had 25-50% responses, and 2/18 (11.1%; Myc17, Myc18) progressed on treatment. Average diminution in tumor burden across the entire cohort was 47.8%. Four images are shown for each animal: Day 0 columns shows the raw image and GFP intensity plot for each fish prior to UNC treatment. Day 14 columns show post-treatment images and intensity plots. GFP Score day 14 columns show final responses, depicted as % of original cancer remaining.
Supplementary Table 1 from Impact of Intrinsic Affinity on Functional Binding and Biological Activity of EGFR Antibodies
Authors: Zhou Yu , Goenaga Anne-Laure , Harms Brian D. , Zou Hao , Lou Jianlong , Conrad Fraser , Adams Gregory P. , Schoeberl Birgit , Nielsen Ulrik B. , Marks James D.
Published: April 2023

PDF file, 51KB, Binding kinetics and affinities of IgG converted from affinity-matured scFv (2224 and P2/4) vs C225 as measured by KinExA.
Supplementary Figure S1 from Analysis of DNA Repair–Related Genes in Breast Cancer Reveals CUL4A Ubiquitin Ligase as a Novel Biomarker of Trabectedin Response
Authors: García María J. , Saucedo-Cuevas Laura Paula , Muñoz-Repeto Iván , Fernández Victoria , Robles María J. , Domingo Samuel , Palacios José , Aracil Miguel , Nieto Antonio , Tercero Juan Carlos , Benítez Javier
Published: April 2023

PDF file - 3 MB, Relative expression of DNA repair genes in cell lines
Supplementary Figure Legends from Pharmacologic Blockade of FAK Autophosphorylation Decreases Human Glioblastoma Tumor Growth and Synergizes with Temozolomide
Authors: Golubovskaya Vita M. , Huang Grace , Ho Baotran , Yemma Michael , Morrison Carl D. , Lee Jisook , Eliceiri Brian P. , Cance William G.
Published: April 2023

PDF file - 22KB