bluuebunny/crossref_metadata_2025 huggingface dataset:
Prognostic Implication of Preoperative Anemia in Redo Cardiac Surgery: A Single-Center Propensity-Matched Analysis
Authors: Rubino Antonino Salvatore , De Santo Luca Salvatore , Montella Antonio Pio , Golini Petrarcone Caterina , Palmieri Lucrezia , Galbiati Denise , Galdieri Nicola , De Feo Marisa
Published: April 2023

Preoperative anemia has been associated with increased morbidity and mortality after cardiac surgery, but little is known about its prognostic value in the setting of redo procedure. A retrospective, observational cohort study of prospectively collected data was undertaken on 409 consecutive patients referred for redo cardiac procedures between January 2011 and December 2020. The EuroSCORE II calculated an average mortality risk of 25.7 ± 15.4%. Selection bias was assessed with the propensity-adjustment method. The prevalence of preoperative anemia was 41%. In unmatched analysis, significant differences between the anemic and nonanemic groups emerged in the risk for postoperative stroke (0.6% vs. 4.4%, p = 0.023), postoperative renal dysfunction (29.7% vs. 15.6%, p = 0.001), a need for prolonged ventilation (18.1% vs. 7.2%, p = 0.002), and high-dosage inotropes (53.1% vs. 32.9%, p < 0.001) along with both length of ICU and hospital stay (8.2 ± 15.9 vs. 4.3 ± 5.4 days, p = 0.003 and 18.8 ± 17.4 vs. 14.9 ± 11.1, p = 0.012). After propensity matching (145 pairs), preoperative anemia was still significantly associated with postoperative renal dysfunction, stroke, and the need for high-dosage inotrope cardiac morbidity. Preoperative anemia is significantly associated with acute kidney injury, stroke, and the need for high-dosage inotropes in patients referred for redo procedures.
Minimal Clinically Important Differences in Inspiratory Muscle Function Variables after a Respiratory Muscle Training Programme in Individuals with Long-Term Post-COVID-19 Symptoms
Authors: del Corral Tamara , Fabero-Garrido Raúl , Plaza-Manzano Gustavo , Fernández-de-las-Peñas César , Navarro-Santana Marcos José , López-de-Uralde-Villanueva Ibai
Published: April 2023

Objective: To establish the minimal clinically important difference (MCID) for inspiratory muscle strength (MIP) and endurance (IME) in individuals with long-term post-COVID-19 symptoms, as well as to ascertain which of the variables has a greater discriminatory capacity and to compare changes between individuals classified by the MCID. Design: Secondary analysis of randomised controlled trial of data from 42 individuals who performed an 8-week intervention of respiratory muscle training programme. Results: A change of at least 18 cmH2O and 22.1% of that predicted for MIP and 328.5s for IME represented the MCID. All variables showed acceptable discrimination between individuals who classified as “improved” and those classified as “stable/not improved” (area under the curve ≥0.73). MIP was the variable with the best discriminative ability when expressed as a percentage of prediction (Youden index, 0.67; sensitivity, 76.9%; specificity, 89.7%). Participants classified as “improved” had significantly greater improvements in quality of life and lung function compared with the participants classified as “stable/not improved”. Conclusion: In individuals with long-term post-COVID-19 symptoms, the inspiratory muscle function variables had an acceptable discriminative ability to assess the efficacy of a respiratory muscle training programme. MIP was the variable with the best discriminative ability, showing better overall performance when expressed as a percentage of prediction.
Osteoid Osteoma, a Diagnostic Problem: A Series of Atypical and Mimicking Presentations and Review of the Recent Literature
Authors: Napora Justyna , Wałejko Szymon , Mazurek Tomasz
Published: April 2023

Osteoid osteoma (OO) is a common benign bone tumour, usually affecting young people. Typically, it is localised to the diaphyses or metaphyses of long bones. The classical manifestation includes distinctive night pain, almost always present, responding well to non-steroidal anti-inflammatory drugs, sometimes accompanied by complaints due to physical activity, and a typical picture on additional tests. A characteristic of osteoid osteoma is the presence of a nidus, usually visible on imaging tests. The nidus generally presents as a single, round lytic lesion up to 1 cm in diameter, surrounded by an area of reactive ossification. However, OO is a multifaceted neoplasm, and its diagnosis can cause numerous difficulties. OO can mimic multiple diseases and vice versa, which often leads to a prolonged diagnostic and therapeutic path and associated complications. There are few literature reviews about the differentiation and diagnostic difficulties of osteoid osteoma. Very effective therapies for this tumour are known, such as ablation and resection. Enhanced detection of osteoid osteoma could result in faster diagnosis and less suffering for the patient, avoidance of complications, and reduced costs of incorrect and prolonged treatment.
Prevalence of Possible Dementia in Patients with Maxillofacial Defects and Difficulty of Inserting Obturator in Maxillectomy Patients: Toward Better Provision of Supportive Care
Authors: Yu Hongli , Fujita Haruka , Akiyama Masako , Sumita Yuka I. , Wakabayashi Noriyuki
Published: April 2023

As society ages, it is important to understand the prevalence of dementia and the difficulties of inserting prostheses in patients with maxillofacial defects in order to clarify issues in supportive care. We screened 183 patients for dementia using the revised Hasegawa’s dementia scale (HDS-R) at the Clinic for Maxillofacial prosthetics, Tokyo Medical and Dental University, and investigated age and sex differences in HDS-R score. We asked 47 of the 183 participants about the difficulty of inserting a maxillofacial obturator prosthesis and collected subjective comments, information about the prosthesis, and data from five assessments. Multiple regression analysis was used to reveal factors associated with insertion difficulty. Overall, 8.7% of the participants were judged to have possible dementia. Men were more likely than women to have possible dementia, and the risk increased with age. Of the 47 participants, 26 reported difficulty inserting their prosthesis, 12 of whom attributed it to their oral defect. Fourteen patients advised following doctor’s instructions to practice insertion in order to become accustomed to it. A lower HDS-R score had a significant impact on insertion difficulty. Cognitive function and difficulty inserting maxillary obturator prostheses should be considered in the provision of continuous supportive care to patients with maxillary defects.
Determination of Relative Weightings for Sacroiliac Joint Pathologies in the OMERACT Juvenile Arthritis Magnetic Resonance Imaging Sacroiliac Joint Score
Authors: Otobo Tarimobo M. , Tolend Mirkamal , Meyers Arthur B. , Sudol-Szopinska Iwona , Joshi Sayali , Stimec Jennifer , Herregods Nele , Jaremko Jacob L. , Tse Shirley M. L. , Haroon Nigil , Moineddin Rahim , Tzaribachev Nikolay , Appenzeller Simone , Znajdek Michal , Perez Manuela , Ligha Aloysius E. , Jans Lennart , Inarejos Clemente Emilio J. , Weiss Pamela , Papakonstantinou Olympia , Kirkhus Eva , van Rossum Marion A. J. , Rumsey Dax G. , Carrino John , Akikusa Jonathan D. , Conaghan Philip G. , Doria Andrea S.
Published: April 2023

This study aims to determine the relative weights (point value) of items of the juvenile idiopathic arthritis magnetic resonance imaging-sacroiliac joint scoring system (JAMRIS-SIJ). An adaptive multicriteria decision analysis was performed using the 1000Minds web application to determine the relative weights of the items in the JAMRIS-SIJ inflammation and damage domains. Experts in imaging and rheumatology independently completed a conjoint analysis survey (CAS) to determine the point value of the measurement items of the JAMRIS-SIJ. Each CAS survey question asked the expert to compare two hypothetical patient profiles, which were otherwise similar but different at two items at a time, and to select which item showed a more severe stage of inflammation or osteochondral damage. In addition, experts ranked 14 JAMRIS-SIJ grade only or image + grade patient vignettes while blinded to the CAS-derived weights. The validity of the weighted JAMRIS-SIJ was tested by comparing the expert CAS-weighted score and the image + grade ranking method. Seventeen experts completed the CAS (11 radiologists and 6 rheumatologists). Considering the point value for inflammation domain items, osteitis (24.7%) and bone marrow edema (24.3%) had higher group-averaged percentage weights compared to inflammation in erosion cavity (16.9%), joint space enhancement (13.1%), joint space fluid (9.1%), capsulitis (7.3%), and enthesitis (4.6%). Similarly, concerning the damage domain, ankylosis (41.3%) and erosion (25.1%) showed higher group-averaged weights compared to backfill (13.9%), sclerosis (10.7%), and fat metaplasia lesion (9.1%). The Spearman correlation coefficients of the CAS-weighted vignette order and unweighted JAMRIS-SIJ grade only order vignettes for all experts were 0.79 for inflammation and 0.80 for damage. The correlations of image vignettes among imaging experts to CAS were 0.75 for inflammation and 0.90 for damage. The multicriteria decision analysis identified differences in relative weights among the JAMRIS-SIJ measurement items. The determination of the relative weights provided expert-driven score scaling and face validity for the JAMRIS-SIJ, enabling the future evaluation of its longitudinal construct validity.
Opioids for Osteoarthritis: Cross-Sectional Survey of Patient Perspectives and Satisfaction
Authors: Schnitzer Thomas J. , Robinson Rebecca L. , Viktrup Lars , Cappelleri Joseph C. , Bushmakin Andrew G. , Tive Leslie , Berry Mia , Walker Chloe , Jackson James
Published: April 2023

Patients often take opioids to relieve osteoarthritis (OA) pain despite limited benefits and potential harms. This study aimed to compare cross-sectional perspectives of patients that were taking prescription opioid (N = 471) or nonopioid medications (N = 185) for OA in terms of satisfaction, expectations of effectiveness, and concerns. Patients prescribed opioids (>7 days) reported more prior treatments (2.47 vs. 1.74), greater mean pain intensity (5.47 vs. 4.11), and worse quality of life (EQ-5D-5L index value mean 0.45 vs. 0.71) than patients prescribed nonopioid medications (all p < 0.0001). Based on linear regression models adjusting for demographics and pain intensity, patients prescribed opioids were less satisfied with overall regimen (3.40 vs. 3.67, p = 0.0322), had less belief that medications were meeting effectiveness expectations (2.72 vs. 3.13, p < 0.0001), and had more concerns about treatments being “not very good” (3.66 vs. 3.22, p = 0.0026) and addiction (3.30 vs. 2.65, p < 0.0001) than patients prescribed nonopioid regimens. When the models were replicated for subgroups with ≥30 days’ medication regimen duration, the findings were consistent with the main analyses. Patients have concerns about the risk of opioid addiction, but those with greater disease burden and more prior treatments continue taking opioid regimens.
Artificial Intelligence in Cardiology: Why So Many Great Promises and Expectations, but Still a Limited Clinical Impact?
Authors: Nicolosi Gian Luigi
Published: April 2023

Looking at the extremely large amount of literature, as summarized in two recent reviews on applications of Artificial Intelligence in Cardiology, both in the adult and pediatric age groups, published in the Journal of Clinical Medicine [...]
Endoscopic Ultrasound-Guided Biliary Drainage
Authors: Doyle John B. , Sethi Amrita
Published: April 2023

Endoscopic retrograde cholangiopancreatography (ERCP) and percutaneous transhepatic biliary drainage (PTBD) are currently first- and second-line therapeutic options, respectively, for the relief of biliary obstruction. In recent years, however, endoscopic ultrasound-guided biliary drainage (EUS-BD) has become an established alternative therapy for biliary obstruction. There are multiple different techniques for EUS-BD, which can be distinguished based on the access point within the biliary tree (intrahepatic versus extrahepatic) and the location of stent placement (transenteric versus transpapillary). The clinical and technical success rates of biliary drainage for EUS-BD are similar to both ERCP and PTBD, and complication rates are favorable for EUS-BD relative to PTBD. As EUS-BD becomes more widely practiced and endoscopic tools continue to advance, the outcomes will likely improve, and the breadth of indications for EUS-BD will continue to expand.
Group A Streptococcus Is Still at Large
Authors: Lu Qinghua , Yu Dingle , Yang Yonghong
Published: April 2023

Group A Streptococcus (GAS) is a major human pathogen that can cause diseases, ranging from mild to severe systemic and invasive diseases [...]
Low-Dose Propofol with Peribulbar Anaesthesia for Cataract Surgery
Authors: Ahmed Mahmoud , Krishna Yamini , Popova Petya , Herbert Rose , Sidaras Gediminas , Choudhary Anshoo , Kaye Stephen B.
Published: April 2023

In this paper, we investigate the effect of sedation using low-dose propofol on patient reported outcome measures (PROMS) in patients undergoing cataract surgery. This is a randomised, single-blinded observational prospective study. Patients undergoing elective cataract surgery using peribulbar anaesthesia over consecutive cataract lists were selected for this trial. Patients were randomised to receive either no sedation or low-dose propofol (20 to 30 mg followed by 10 mg increments until the patient developed slurred speech alone) prior to the administration of local anaesthesia. Pain, satisfaction, anxiety, needle recall, pulse, and blood pressure (BP) were measured. A total of 97 patients were included, 50 of whom received propofol. There were 4 senior surgeons and anaesthetists. There were no ocular or systemic complications and all patients had uncomplicated surgery. Anxiety (p = 0.026), needle recall (p < 0.001), difference in systolic BP (p = 0.043), and pulse (p = 0.046) were dependent on patient age (p < 0.001) and the use of propofol (p = 0.007). Lower pain was associated with propofol (p = 0.008), as well as lower anxiety (p = 0.002), and increased patient age (p = 0.014). The administration of propofol was significantly associated with lower needle recall (p < 0.001), pre- to post-operative difference in systolic BP (p = 0.029), and mean BP (p = 0.044). Low-dose propofol given immediately prior to administration of local anaesthesia was associated with reduced pain and needle recall, as well as lower BP.
Histopathological Biocompatibility Evaluation of TheraCal PT, NeoMTA, and MTA Angelus in a Murine Model
Authors: Quiñonez-Ruvalcaba Francelia , Bermúdez-Jiménez Carlos , Aguilera-Galavíz Luis Alejandro , Villanueva-Sánchez Francisco G , García-Cruz Salvador , Gaitán-Fonseca César
Published: April 2023

The aim of this study was to evaluate the biocompatibility of the regeneration of the dentin–pulp complex in a murine model with different treatments with MTA Angelus, NeoMTA, and TheraCal PT. An in vivo controlled experimental study of 15 male Wistar rats forming three study groups, the upper and lower central incisors were selected where pulpotomies were conducted, leaving a central incisor as control at 15, 30, and 45 days. For data analysis, these were expressed as mean ± standard deviation and were examined by Kruskal–Wallis test. Three factors were analyzed as follows: “inflammatory infiltrate; disorganization of pulp tissue, and the formation of reparative dentin”. No statistical significance was found between the different groups (p > 0.05). Treatment with these three biomaterials (MTA, TheraCal PT, and Neo MTA) presented an inflammatory infiltrate and slight disorganization of the odontoblast layer in the pulp tissue of a murine model, with normal coronary pulp tissue and the formation of reparative dentin in the three experimental groups. Thus, we are able to conclude that all three are biocompatible materials.
Tropoelastin-Pretreated Exosomes from Adipose-Derived Stem Cells Improve the Synthesis of Cartilage Matrix and Alleviate Osteoarthritis
Authors: Meng Shuo , Tang Cong , Deng Muhai , Yuan Jie , Fan Yanli , Gao Shasha , Feng Yong , Yang Junjun , Chen Cheng
Published: April 2023

Mesenchymal stem cells (MSCs) have recently been widely used to treat osteoarthritis (OA). Our prior research shows that tropoelastin (TE) increases MSC activity and protects knee cartilage from OA-related degradation. The underlying mechanism might be that TE regulates the paracrine of MSCs. Exosomes (Exos), the paracrine secretion of MSCs, have been found to protect chondrocytes, reduce inflammation, and preserve the cartilage matrix. In this study, we used Exos derived from TE-pretreated adipose-derived stem cells (ADSCs) (TE-ExoADSCs) as an injection medium, and compared it with Exos derived from unpretreated ADSCs (ExoADSCs). We found that TE-ExoADSCs could effectively enhance the matrix synthesis of chondrocytes in vitro. Moreover, TE pretreatment increased the ability of ADSCs to secrete Exos. In addition, compared with ExoADSCs, TE-ExoADSCs exhibited therapeutic effects in the anterior cruciate ligament transection (ACLT)-induced OA model. Further, we observed that TE altered the microRNA expression in ExoADSCs and identified one differentially upregulated microRNA: miR-451-5p. In conclusion, TE-ExoADSCs helped maintain the chondrocyte phenotype in vitro, and promoted cartilage repair in vivo. These therapeutic effects might be related with the altered expression of miR-451-5p in the ExoADSCs. Thus, the intra-articular delivery of Exos derived from ADSCs with TE pretreatment could be a new approach to treat OA.
First Review of Conductive Electrets for Low-Power Electronics
Authors: Chung D. D. L.
Published: April 2023

This is the first review of conductive electrets (unpoled carbons and metals), which provide a new avenue for low-power electronics. The electret provides low DC voltage (μV) while allowing low DC current (μA) to pass through. Ohm’s Law is obeyed. The voltage scales with the inter-electrode distance. Series connection of multiple electret components provides a series voltage that equals the sum of the voltages of the components if there is no bending at the connection between the components. Otherwise, the series voltage is below the sum. Bending within the component also diminishes the voltage because of the polarization continuity decrease. The electret originates from the interaction of a tiny fraction of the carriers with the atoms. This interaction results in the charge in the electret. Dividing the electret charge by the electret voltage V’ provides the electret-based capacitance C’, which is higher than the permittivity-based capacitance (conventional) by a large number of orders of magnitude. The C’ governs the electret energy (1/2 C’V’2) and electret discharge time constant (RC’, where R = resistance), as shown for metals. The discharge time is promoted by a larger inter-electrode distance. The electret discharges occur upon short-circuiting and charge back upon subsequent opencircuiting. The discharge or charge of the electret amounts to the discharge or charge of C’.
A Vertical Electro-Osmosis Method to Improve the Bearing Capacity of Piles in Marine Soft Clay
Authors: Cui Yunliang , Zhong Fangtao , Qi Changguang , Yang Xukun , Gao Xuanyuan
Published: April 2023

A vertical electro-osmosis method was proposed to improve the bearing capacity of piles in marine soft clay foundations. A top-down electro-osmosis test was conducted by setting an anode and cathode at the top and bottom of the pile, respectively, while the settings of bottom-up electro-osmosis were set in the opposite way. At the same time, a pile without electro-osmosis was also set up for comparison. The variation law of water content, water discharge volume, soil pressure, and surface settlement of soil around the pile during electro-osmosis was tested and analyzed. A direct shear test and static load test were carried out to study the effects of vertical electro-osmosis on the shear strength of soil and the bearing capacity of the pile. The experimental results show that vertical electro-osmosis can significantly improve the bearing capacity of the pile and the shear strength of soil around the pile. The bearing capacity of the piles in the top-down electro-osmosis test was 16.7% higher than that in the bottom-up electro-osmosis test, and the amount of water discharged was 41.69% higher. Compared with the horizontal electro-osmosis around the pile, the vertical electro-osmosis had a faster drainage speed, better soil consolidation, and a slightly smaller increase in the bearing capacity of the pile. Because vertical electro-osmosis is easy to implement on concrete piles, the new method proposed in this study has a broad application prospect.
Effect of Salinity and Temperature on the Dispersion of Spilled Oil in the Presence of Microplastics
Authors: Gao Huan , Qi Zhixin , Yu Xinping , An Yaya , Liu Ziyue , Yang Miao , Xiong Deqi
Published: April 2023

Both oil spill and microplastics (MPs) are major issues in marine environments. After a spill, the oil film may disperse into the water column as droplets under the function of sea waves. The oil dispersion may be affected due to the attachment of oil to MPs. In this paper, the impacts of salinity and temperature on the dispersion of spilled oil in the presence of MPs were individually studied by batch conical flask oscillation experiments. The results indicated that the rise in salinity or temperature displayed a more significant effect on promoting, rather than inhibiting, oil dispersion with MPs. When the salinity rose from 15% to 35%, the oil dispersion efficiency (ODE) with the 13 μm polyethylene (PE) and polystyrene (PS) MPs was increased by 10.4% and 12.9%, respectively; when the temperature rose from 10 °C to 25 °C, the corresponding ODE was increased by 15.6% and 12.7%, respectively. In addition, the volumetric mean diameter (VMD) of the dispersed oil droplets decreased with an increase in salinity or temperature. Furthermore, the 13 μm MPs showed a higher impact on the oil dispersion than 106 μm of MPs, and the ODE with PE MPs was greater than that with PS MPs. The findings of this study expanded the understanding of the migration of spilled oil in seawater in the presence of MPs and may further improve the capability of predicting the impact of oil spills by marine environment managers.
Control Parameters Optimization of Accumulator in Hydraulic Power Take-Off System for Eccentric Rotating Wave Energy Converter
Authors: Xue Gang , Zhang Zhenquan , Qin Jian , Huang Shuting , Liu Yanjun
Published: April 2023

To improve the efficiency and stability of an eccentric rotating wave energy converter (ERWEC), the adaptive hydraulic power-take-off (PTO) system with an accumulator is designed and developed. Experiments are performed to analyze the effects of trigger pressure, delay time, and open state duration on average output power and power fluctuation index. The results show that the effects of those three control parameters of accumulator on output power are strongly coupled. The experimental examples are designed based on the optimal Latin hypercube sampling (OLHS) method, and the nonparameterized agent models of control parameters to output power indices are established based on the Gaussian process regression (GPR) method. With the help of sensitivity analysis, it is found that the coupled effect of delay time and open state duration on the power fluctuation index is greater than that on the average output power. Furthermore, the optimal combination of control parameters is obtained by non-dominated sorting genetic algorithm-III (NSGA-III), which improves the amount and stability of output power from a hydraulic PTO system. This paper is of important significance for parameter setting of hydraulic PTO systems with an accumulator for wave energy converter, and provides the basis for the real-time adjustment of control parameters under complex sea conditions.
Two-Phase Flow Pattern Identification by Embedding Double Attention Mechanisms into a Convolutional Neural Network
Authors: Qiao Weiliang , Guo Hongtongyang , Huang Enze , Chen Haiquan , Lian Chuanping
Published: April 2023

There are inevitable multiphase flow problems in the process of subsea oil-gas acquisition and transportation, of which the two-phase flow involving gas and liquid is given much attention. The performance of pipelines and equipment in subsea systems is greatly affected by various flow patterns. As a result, correctly and efficiently identifying the flow pattern in a pipeline is critical for the oil and gas industry. In this study, two attention modules, the convolutional block attention module (CBAM) and efficient channel attention (ECA), are introduced into a convolutional neural network (ResNet50) to develop a gas–liquid two-phase flow pattern identification model, which is named CBAM-ECA-ResNet50. To verify the accuracy and efficiency of the proposed model, a collection of gas–liquid two-phase flow pattern images in a vertical pipeline is selected as the dataset, and data augmentation is employed on the training set data to enhance the generalization capability and comprehensive performance of the model. Then, comparison models similar to the proposed model are obtained by adjusting the order and number of the two attention modules in the two positions and by inserting other different attention modules. Afterward, ResNet50 and all proposed models are applied to classify and identify gas–liquid two-phase flow pattern images. As a result, the identification accuracy of the proposed CBAM-ECA-ResNet50 is observed to be the highest (99.62%). In addition, the robustness and complexity of the proposed CBAM-ECA-ResNet50 are satisfactory.
Global Change Factors Influence Plant-Epichloë Associations
Authors: Bastías Daniel A. , Ueno Andrea C. , Gundel Pedro E.
Published: April 2023

There is an increasing interest in determining the influence of global change on plant–microorganism interactions. We review the results of experiments that evaluated the effects of the global change factors carbon dioxide, ozone, temperature, drought, flooding, and salinity on plant symbioses with beneficial Epichloë endophytes. The factors affected the performance of both plants and endophytes as well as the frequency of plants symbiotic with the fungus. Elevated carbon dioxide levels and low temperatures differentially influenced the growth of plants and endophytes, which could compromise the symbioses. Furthermore, we summarise the plant stage in which the effects of the factors were quantified (vegetative, reproductive, or progeny). The factors ozone and drought were studied at all plant stages, but flooding and carbon dioxide were studied in just a few of them. While only studied in response to ozone and drought, evidence showed that the effects of these factors on symbiotic plants persisted trans-generationally. We also identified the putative mechanisms that would explain the effects of the factors on plant–endophyte associations. These mechanisms included the increased contents of reactive oxygen species and defence-related phytohormones, reduced photosynthesis, and altered levels of plant primary metabolites. Finally, we describe the counteracting mechanisms by which endophytes would mitigate the detrimental effects of the factors on plants. In presence of the factors, endophytes increased the contents of antioxidants, reduced the levels of defence-related phytohormones, and enhanced the plant uptake of nutrients and photosynthesis levels. Knowledge gaps regarding the effects of global change on plant–endophyte associations were identified and discussed.
Proposal of Four New Aureobasidium Species for Exopolysaccharide Production
Authors: Wu Feng , Feng Zixuan , Wang Manman , Wang Qiming
Published: April 2023

In this study, 99 strains of Aureobasidium species were isolated from various samples collected from different locations in China, among which 14 isolates showed different morphological characteristics to other strains identified as known Aureobasidium species. Based on morphological characteristics, those 14 strains were classified into four groups, represented by stains of KCL139, MDSC−10, XZY411−4, and MQL9−100, respectively. Molecular analysis of the internal transcriptional spacer (ITS) and part of the large ribosome subunit (D1/D2 domains) indicated that those four groups represent four new species in the Aureobasidium. Therefore, the names Aureobasidium insectorum sp. nov., A. planticola sp. nov., A. motuoense sp. nov., and A. intercalariosporum sp. nov. are proposed for KCL139, MDSC−10, XZY411−4, and MQL9−100, respectively. We also found that there were differences in the yield of exopolysaccharides (EPS) among and within species, indicating strain-related exopolysaccharide-producing diversity.
Differential Recognition of Clinically Relevant Sporothrix Species by Human Mononuclear Cells
Authors: García-Carnero Laura C. , Martínez-Duncker Iván , Gómez-Gaviria Manuela , Mora-Montes Héctor M.
Published: April 2023

Sporotrichosis is a human and animal fungal infection distributed worldwide that is caused by the thermodimorphic species of the Sporothrix pathogenic clade, which includes Sporothrix brasiliensis, Sporothrix schenckii, and Sporothrix globosa. The cell wall composition and the immune response against the Sporothrix species have been studied mainly in S. brasiliensis and S. schenckii, whilst little is known about the S. globosa cell wall and the immune response that its components trigger. Therefore, in this study, we aimed to analyze the cell wall composition of S. globosa in three morphologies (germlings, conidia, and yeast-like cells) and the differences in cytokine production when human peripheral blood mononuclear cells (PBMCs) interact with these morphotypes, using S. schenckii and S. brasiliensis as a comparison. We found that S. globosa conidia and yeast-like cells have a higher cell wall chitin content, while all three morphologies have a higher β-1,3-glucan content, which was found most exposed at the cell surface when compared to S. schenckii and S. brasiliensis. In addition, S. globosa has lower levels of mannose- and rhamnose-based glycoconjugates, as well as of N- and O-linked glycans, indicating that this fungal cell wall has species-specific proportions and organization of its components. When interacting with PBMCs, S. brasiliensis and S. globosa showed a similar cytokine stimulation profile, but with a higher stimulation of IL-10 by S. globosa. Additionally, when the inner cell wall components of S. globosa were exposed at the surface or N- and O-glycans were removed, the cytokine production profile of this species in its three morphotypes did not significantly change, contrasting with the S. schenckii and S. brasiliensis species that showed different cytokine profiles depending on the treatment applied to the walls. In addition, it was found that the anti-inflammatory response stimulated by S. globosa was dependent on the activation of dectin-1, mannose receptor, and TLR2, but not TLR4. All of these results indicate that the cell wall composition and structure of the three Sporothrix species in the three morphologies are different, affecting their interaction with human PBMCs and generating species-specific cytokine profiles.
Arthrobotrys blastospora sp. nov. (Orbiliomycetes): A Living Fossil Displaying Morphological Traits of Mesozoic Carnivorous Fungi
Authors: Zhang Fa , Boonmee Saranyaphat , Yang Yao-Quan , Zhou Fa-Ping , Xiao Wen , Yang Xiao-Yan
Published: April 2023

The evolution of carnivorous fungi in deep time is still poorly understood as their fossil record is scarce. The approximately 100-million-year-old Cretaceous Palaeoanellus dimorphus is the earliest fossil of carnivorous fungi ever discovered. However, its accuracy and ancestral position has been widely questioned because no similar species have been found in modern ecosystems. During a survey of carnivorous fungi in Yunnan, China, two fungal isolates strongly morphologically resembling P. dimorphus were discovered and identified as a new species of Arthrobotrys (Orbiliaceae, Orbiliomycetes), a modern genus of carnivorous fungi. Phylogenetically, Arthrobotrys blastospora sp. nov. forms a sister lineage to A. oligospora. A. blastospora catches nematodes with adhesive networks and produces yeast-like blastospores. This character combination is absent in all other previously known modern carnivorous fungi but is strikingly similar to the Cretaceous P. dimorphus. In this paper, we describe A. blastospora in detail and discuss its relationship to P. dimorphus.
Lower All-Cause Mortality Risk in Females and Males with Peripheral Artery Disease following Pain-Free Home-Based Exercise: A 7-Year Observational Study
Authors: Lamberti Nicola , Traina Luca , Savriè Caterina , Tsolaki Elpiniki , Rinaldo Natascia , Straudi Sofia , Guerzoni Franco , Napoli Nicola , Manfredini Roberto , Gasbarro Vincenzo , Manfredini Fabio
Published: April 2023

We evaluated the sex-specific difference in response upon participation in an exercise program with respect to the risk of adverse clinical outcomes among patients with peripheral artery disease (PAD) and claudication. The records of 400 PAD patients were assessed between 2012 and 2015. Two hundred of them were addressed to a walking program prescribed at the hospital and executed at home at symptom-free walking speed (Ex), while the remaining 200 acted as a control group (Co). The number and date of deaths, all-cause hospitalizations, and amputations for a 7-year period were collected from the regional registry. At baseline, no differences were observed (MEXn = 138; FEXn = 62; MCOn = 149; FCOn = 51). The 7-year survival rate was significantly higher in FEX (90%) than in MEX (82% hazard ratio, HR: 0.542 95% CI 0.331–0.885), FCO (45%, HR: 0.164 95% CI 0.088–0.305), and MCO (44%; HR: 0.157 95% CI 0.096–0.256). A significantly lower rate of hospitalization (p < 0.001) and amputations (p = 0.016) was observed for the Ex group compared to the Co group, without differences by sex. In conclusion, in PAD patients, active participation in a home-based pain-free exercise program was associated with a lower rate of death and better long-term clinical outcomes, particularly among women.
Impact of Financial Technology on Improvement of Banks’ Financial Performance
Authors: Baker Hafez , Kaddumi Thair A. , Nassar Mahmoud Daoud , Muqattash Riham Suleiman
Published: April 2023

This study investigates the main financial technologies adopted by banks to improve their financial performance. The study population consists of commercial banks listed on the Amman Stock Exchange and Abu Dhabi Securities Exchange, and includes financial information and data from 2012 to 2020. A total of 115 questionnaires, consisting of five questionnaires for each bank, were distributed to the study population in Jordan and the United Arab Emirates. The dependent variable is financial performance, while the independent variable is financial technology (FinTech). Multiple linear regression analysis was conducted to test the hypotheses. The results showed that FinTech has a positive effect on both total deposit and net profits. This study recommends that banks be encouraged to adopt inclusive strategies to attain sustainable development.
A Recommendation System in E-Commerce with Profit-Support Fuzzy Association Rule Mining (P-FARM)
Authors: Dogan Onur
Published: April 2023

E-commerce is snowballing with advancements in technology, and as a result, understanding complex transactional data has become increasingly important. To keep customers engaged, e-commerce systems need to have practical product recommendations. Some studies have focused on finding the most frequent items to recommend to customers. However, this approach fails to consider profitability, a crucial aspect for companies. From the researcher’s perspective, this study introduces a novel method called Profit-supported Association Rule Mining with Fuzzy Theory (P-FARM), which goes beyond just recommending frequent items and considers a company’s profit while making product suggestions. P-FARM is an advanced data mining technique that creates association rules by finding the most profitable items in frequent item sets. From the practitioners’ standpoints, this method helps companies make better decisions by providing them with more profitable products with fewer rules. The results of this study show that P-FARM can be a powerful tool for improving e-commerce sales and maximizing profit for businesses.
Assessing and Comparing the Visual Comfort of Streets across Four Chinese Megacities Using AI-Based Image Analysis and the Perceptive Evaluation Method
Authors: Shao Yuhan , Yin Yuting , Xue Zhenying , Ma Dongbo
Published: April 2023

Environmental perception studies have long been constrained by research scales due to the difficulties in obtaining users’ perceptive data and constructing their relation to environmental attributes. With the help of big data from street view images, this study compares the visual comfort of streets across four Chinese megacities with evidently distinct geographical characteristics. A multi-method approach involving traditional comfort measurements, image analysis based on deep learning algorithms and spatial mapping using geographic information systems was used to investigate the visual components of urban streets at the city scale and their influential mechanisms. In general, the four cities ranked by visual comfort were Beijing first, then Shenzhen, Shanghai and Guangzhou. The results also suggested that the spatial distribution of the four cities’ street visual comfort is obviously different. In Shanghai and Beijing, streets with a higher comfort level are mostly concentrated within the central city, while the highly comfort streets are mostly distributed along the coast and rivers in Shenzhen and Guangzhou. Thus, it is reasonable to speculate that the streets’ visual comfort relates significantly to their urban planning and construction process. Moreover, seven indicators have been identified as influential to street comfort, among which ‘vegetation’, ‘terrain’ and ‘rider’ are positive indicators, while ‘architecture’, ‘pedestrians’, ‘motorcycles’ and ‘bicycles’ have negative influences. Comparing street comfort indicators of the four case study cities, it was observed that ‘vegetation’ and ‘terrain’ have the most consistent positive influences across cities, while the high visibility of ‘building’ on streets is most likely to lead to a low level of perceived comfort. The research outcomes provide applicable cues for large-scale street evaluation research and illustrate an efficient street design approach that can both respond to local characteristics and human perceptive needs.
A Replicable Valorisation Model for the Adaptive Reuse of Rationalist Architecture
Authors: Lami Isabella M. , Todella Elena , Prataviera Enrica
Published: April 2023

Adaptive reuse has progressively become a useful approach for generating new values concerning abandoned or underused buildings, sites, and areas to the extent that the topic is no longer conceived and perceived merely as a “bricks-and-mortar” issue. Instead, it has a dual nature: (i) one that is technical, linked to the difficult balance between low costs and fostering sustainable building solutions, and (ii) one that is social, which refers to social equity, well-being, and quality of life. Within this context, urban and architectural transformations are among those human activities that play a key role in shaping the territory in an increasingly invasive acceleration of urbanization processes. However, it is precisely here that adaptive reuse can counteract such alterations. This paper proposes a sustainable, economically feasible, and replicable valorisation model for the evaluation of adaptive reuse possibilities of a particular historical–architectural heritage, which is vast and widespread in Italy and an important example of Rationalist architecture. Such a model incorporates flexible and easily replicable spatial implications precisely because it is specifically related to the characteristics of an open-plan structure. In doing so, it aims to redefine the valorisation model based on a constant dialogue between the project and market analysis; the replicability of project strategies for “families” of historic buildings; and the need for the project’s ability to change and adapt according to emerging requirements.
Integrating Erosion Potential Model (EPM) and PAP/RAC Guidelines for Water Erosion Mapping and Detection of Vulnerable Areas in the Toudgha River Watershed of the Central High Atlas, Morocco
Authors: Elbadaoui Kamal , Mansour Soukaina , Ikirri Mustapha , Abdelrahman Kamal , Abu-Alam Tamer , Abioui Mohamed
Published: April 2023

This study aimed to evaluate the extent and severity of water erosion in the Toudgha river catchment in the Central High Atlas of Morocco using two different erosion models, the Erosion Potential Model (EPM) and the Priority Actions Programme/Regional Activity Centre (PAP/RAC) model. From the modeling results, the catchment was affected by varying degrees of erosion, ranging from “very slight” to “excessive”, with different locations identified under each model. The very high erosion areas were located in the extreme northwest of the catchment area for both of the applied models, covering 9.65% (according to PAP/RAC) and 8.56% (EPM) of the total area primarily driven by factors such as intense rainfall events, limited vegetation cover, high soil erodibility due to low organic matter content and coarser soil texture, and human activities such as overgrazing and land use changes, which exacerbate the effects of these natural factors on water erosion in these semi-arid areas. The study’s findings suggest that erosion is a significant concern in these environmental areas and provide valuable information for designing effective erosion control measures and guiding soil and environmental management practices. Both models effectively simulated the erosion phenomenon and provided useful tools for soil and environmental management. The EPM model can be used to design effective erosion control measures, while the PAP/RAC model can be used to develop a comprehensive strategy for the sustainable management of the catchment area. These results have implications for the implementation of effective erosion control measures in mountainous watersheds and highlight the need for further research in this area.
White Clover (Trifolium repens L.) Cultivation as a Means of Soil Regeneration and Pursuit of a Sustainable Food System Model
Authors: Sawicka Barbara , Krochmal-Marczak Barbara , Sawicki Józef , Skiba Dominika , Pszczółkowski Piotr , Barbaś Piotr , Vambol Viola , Messaoudi Mohammed , Farhan Alaa K.
Published: April 2023

Background: Currently, in the face of constant climate change and the development of the mining industry, recovering soils degraded by industry for agricultural production and ensuring more food security for the world has become more difficult. Soil contamination is of particular concern as it affects not only human health but also vegetation growth and the biological environment. The aim: The aim of our research is to develop an appropriate cultivation technology in the area of former and present oil extraction areas and monitor their recovery for agricultural purposes and, thus, for food production. Methods: Experimental, descriptive, laboratory, and comparative methods were used. Results: A significantly decreased content of PAHs in the tested soil under the influence of the “Green technology” was observed just in the third year of the research. Eight years after the introduction of “green technology”, the sum of PAHs in the soil degraded by the oil extraction industry was more than 2-fold reduced. Therefore, there is a need to develop a nature-friendly and cost-effective method of removing and minimizing the effects of soil contamination by oil and its products. Conclusions: T. repens turned out to be a species that significantly prevents the degradation of the agricultural environment and restores soil for agricultural use, consequently encouraging the production of food safe for humans. The immeasurable effect of the use of “Green technology” was to ensure the biodiversity of the grasslands and to return the sources of natural nitrogen bound by bacteria of the genus Rhizobium in coexistence with plants from the Fabaceae family.
The Possibility of Eidetic Memory in a Patient Report of Epileptogenic Zone in Right Temporo-Parietal-Occipital Cortex
Authors: Berry Brent M. , Miller Laura R. , Berns Meaghan , Kucewicz Michal
Published: April 2023

Eidetic memory has been reported in children and in patients with synesthesia but is otherwise thought to be a rare phenomenon. Presented herein is a patient with right-sided language dominance, as proven via multiple functional imaging and neuropsychometric methods, who has a seizure onset zone in the right temporo-parietal-occipital cortex. This patient’s medically refractory epilepsy and thus hyperactive cortex could possibly contribute to near eidetic ability with paired-associates learning tasks (in both short-term and long-term retention). There are reports of epilepsy negatively affecting memory, but as far as the authors are aware to date, there is limited evidence of any lesion enhancing cognitive functions (whether through direct lesion or via compensatory mechanism) that would be localized to a seizure onset zone in the dominant temporo-parietal-occipital junction.
Role of Oritavancin in the Treatment of Infective Endocarditis, Catheter- or Device-Related Infections, Bloodstream Infections, and Bone and Prosthetic Joint Infections in Humans: Narrative Review and Possible Developments
Authors: Lupia Tommaso , De Benedetto Ilaria , Bosio Roberta , Shbaklo Nour , De Rosa Francesco Giuseppe , Corcione Silvia
Published: April 2023

Oritavancin is a long-acting lipoglycopeptide with in vitro activity against Gram-positive pathogens, as well as good bactericidal activity and sterilisation ability in biofilm. It has been approved for acute bacterial skin and skin structure infections (ABSSSI), but recent reports have demonstrated possible off-label uses, such as for vancomycin resistant enterococci (VRE), deep-seated infections including those involving prosthetic material and invasive infections. The aim of this work is to review the uses of oritavancin outside of ABSSSI, focusing on its real-life applications on infective endocarditis, catheter- or device-related infections, bloodstream infections, and bone and prosthetic joint infections in humans, as well as possible future applications. We performed a narrative review, collecting the literature published between 1 December 2002 and 1 November 2022 on PubMed and the Cochrane Library using the term ‘oritavancin’. Available studies have shown how effective it is in different settings, suggesting an opportunity for step-down strategies or outpatient management of infections requiring a long duration of antibiotic treatment. So far, evidence is still scarce, and limited to a few studies and case reports, mostly focusing on Staphylococcus aureus as the major isolate. Concerns about fluid intake for dilution and interaction with coagulation markers also need to be taken into account. Further studies are required in order to assess the safety and effectiveness of Oritavancin in vascular, prosthetic, or device-related infections, as well as in resistant Gram-positive bacteria or enterococcal infections.