bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of Core Entrustable Professional Activities for Indonesian Undergraduate Medical Education: The Experience of Universitas Muhammadiyah Jakarta
Authors:   Department of Medical Education, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur Malaysia
Published: December 2023

Indonesia has implemented Competency-Based Education (CBE) since 2006 based on a national standard for physician competencies. This study aimed to develop Core Entrustable Professional Activities (EPAs) for Indonesian undergraduate medical programs to remedy the challenge of translating competencies into professional activities in CBE. Two rounds of modified Delphi were employed in October-November 2022. The research subjects selected were (i) experts in medicine such as internal medicine, surgery, medical education, etc., and (ii) medical teachers in the preclinical/clinical stage for two years or more. Fifteen experts were involved in both Delphi rounds. The first Delphi instrument referring to literature frameworks included 34 professional activities for individual healthcare tasks and 17 for family-community medicine/public health. The second Delphi instruments used were based on the first-round results. After the first Delphi, 31 individual healthcare tasks and all family-community medicine/public health tasks reached a consensus. One expert suggested two additional family-community medicine/public health activities. The second Delphi instrument listed the percentage of agreement for individual healthcare tasks and family-community medicine/public health tasks, including the two additional activities. After the second-round of Delphi, two individual healthcare tasks and one family-community medicine/public health task had not reached a consensus However, 94.7% of activities were still acceptable as Core EPAs in family-community medicine and public health services. In conclusion, developing EPAs for undergraduate medical programs using two rounds of the Delphi method resulted in 32 individual medical service activities and 18 family medicine-community/public health tasks. These core EPAs were expected to facilitate the translation of competencies into professional activities.
Intention to Use Modern Contraception among Spouses of Women With Diabetes and its Associated Factors
Authors:   Department of Family Medicine, 14th floor, Preclinical Block, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia.
Published: December 2023

Women with diabetes are at high risk of adverse pregnancy outcomes if glycemic control is poor. Delaying pregnancy with effective contraception is crucial to allow diabetes to be optimised. Lack of encouragement and disapproval from the husbands leads to poor contraceptive use among women. Therefore, this study assessed the intention to use modern contraception among spouses of women with diabetes and its associated factors. A cross-sectional study was conducted in two clinics from December 2022 to March 2023. A total of 207 men aged 18 years and above, with wives having diabetes, within the reproductive age group were recruited. An online questionnaire was distributed, comprising sociodemographic characteristics, reproductive aspects, including intention for modern contraception use, past experience of contraception, spousal communication, a desire for children, and received contraceptive counselling. Knowledge of diabetes-related pregnancy risk and perception of contraception use in women were also included in the questionnaire. Only 52.7% of men had the intention. Educational level (AOR 2.41, 95% CI: 1.17-4.96), previous experience (AOR 3.3, 95% CI: 1.55-6.99), spousal communication (AOR 2.63, 95% CI: 1.19-5.85), wife’s age (AOR 0.94, 95% CI: 0.89-0.99) and perception towards contraception (AOR 0.98, 95% CI: 0.96-0.99) were the significant factors. Efforts should be made to ensure men have knowledge and correct perceptions towards contraception.
Fracture Resistance, Failure Mode and Pull-Out Bond Strength of Polymer-Infiltrated Ceramic-Network Post-Core Fabricated using Computer-Aided Design/Computer-Aided Manufacturing
Authors:   Centre of Restorative Studies, Faculty of Dentistry, Universiti Teknologi MARA, 47000 Sungai Buloh Campus, Selangor, Malaysia.
Published: December 2023

This study compared fracture resistance (FR), failure mode (FM), and pull-out retention in endodontically-treated teeth restored with computer-aided design-and-manufacturing polymer-infiltrated ceramic networks (PICN) to cast post-core. A total of 45 maxillary central incisors were selected, endodontically treated, and were prepared to receive the post-core restorations. The specimens were randomly divided into five groups (n = 9): CG: control (without post-core); NC1, NC2: cast nickel-chromium (Ni-Cr) post-core; and VE1, VE2: PICN post-core. Groups CG, NC1, and VE1 were subjected to the FR test, while Groups NC2 and VE2 were subjected to the pull-out retention test. FR were recorded, and FM were classified as favourable or non-favourable, while the degree of retention in the maximum force was recorded in Newton. A one-way ANOVA was used to assess the FR, and an independent T-test was used for retention of post-core. No significant mean differences of FR between Ni-Cr versus PICN group (p = 0.261). Non-favourable FM was recorded in all samples in the NC group, with 88.9% of the VE group showed favourable FM. No significant mean differences were recorded in retention between NC2 and VE2 (p>0.05). PICN post-core exhibited favourable FR, FM, and retention values, thus having the potential to be used as a substitute post-core in endodontically-treated anterior teeth.
The Delayed-Steroid-Strategy (DSS) for Idiopathic Granulomatous Mastitis during the COVID-19 Pandemic: A Case Series
Authors:   Breast Reconstructive Division, Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Kuala Lumpur, Malaysia.
Published: December 2023

Idiopathic granulomatous mastitis (IGM) is an inflammatory disease. It is often treated with steroids which could result in the recipient having an impaired immune defence and increases risk of getting infections. This could also hinder an adequate immune response post vaccination and render vaccines to be less effective. This was a study to assess the role and outcome of non steroidal anti-inflammatory drugs (NSAIDs) to delay corticosteroid treatment. This strategy aims to allow the patients to achieve complete vaccination with adequate post vaccination response for better COVID-19 protection prior to commencement of steroids. All three newly diagnosed patients with IGM completed their NSAIDs bridging therapy. None of them reported any worsening of disease during that time.
Synthesis and Characterization of Novel 2,4-Diaryloctahydro-2H-Chromene Derivatives with Four Stereocenters
Authors: Gezegen Hayreddin
Published: December 2023

Chromene derivatives are among the natural compounds and they can also be easily obtained synthetically. They are one of the most commonly used skeletons in heterocyclic chemistry. Chromene derivatives are used in the cosmetic and pigment industries as well as having a wide spectrum of biological activity. Synthesis of chromene derivatives and their application areas is a current topic. In this study, it is aimed to synthesis and characterization of new chromene derivatives by catalysis of molecular iodine starting from 1,5-diol derivatives with chiral centers. In this context, 8 new 2,4-diaryloctahydro-2H-chromene derivatives were synthesized in high yields and their structure determinations were made by spectroscopic methods (1H-NMR, 13C-NMR, 2D-NMR, GCMS and FTIR) and their stereochemistry was determined.
Modern concepts about the pathogenesis of thrombosis of various etiologies
Authors: Khismatullin Rafael R. , Litvinov Rustem I.
Published: December 2023

Thrombosis becomes the cause and complication of many cardiovascular diseases, and their prevalence remains a leader in the structure of morbidity and mortality in Russia and throughout the world. Modern fundamental and clinical research has significantly supplemented traditional ideas about the mechanisms of thrombus formation. First of all, Virchow's triad has been rethought, in which, according to new data, the leading role is assigned to vascular damage, and slowing down blood flow plays a primary role in the formation of only venous, but not arterial, blood clots. In recent years, the mechanisms of endothelial dysfunction underlying thrombosis associated with inflammatory (immunothrombosis) and atherosclerotic (atherothrombosis) damage to the vascular wall have been studied in detail. The cellular and molecular mechanisms of acquired hypercoagulability and hereditary thrombophilia have been deciphered. The traditional concept of dividing blood clots into “red” (venous, consisting of fibrin and red blood cells) and “white” (arterial, platelet) is being revised. It has been shown that red blood cells can occupy most of the volume of not only venous, but also arterial thrombi, and play an important role in thrombus formation reactions. The process of compression (contraction, retraction) of blood clots, caused by contraction of activated platelets, changing the structure of the blood clot and affecting the course and outcome of thrombosis, is being actively studied. A deep understanding of the pathogenesis of thrombosis, taking into account modern concepts, is necessary for effective prevention, early diagnosis and treatment of thrombotic conditions.
Первичные опухоли центральной нервной системы
Authors: Улитин А. Ю. , Желудкова О. Г. , Иванов П. И. , Кобяков Г. Л. , Мацко М. В. , Насхлеташвили Д. Р. , Проценко С. А. , Рыжова М. Ф.
Published: December 2023

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Рак молочной железы
Authors: Тюляндин С. А. , Артамонова Е. В. , Жигулев А. Н. , Королева И. А. , Пароконная А. А. , Семиглазова Т. Ю. , Стенина М. Б. , Фролова М. А.
Published: December 2023

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Злокачественные неэпителиальные опухоли яичников
Authors: Гуторов С. Л. , Новикова Е. Г. , Румянцев А. А. , Трякин А. А. , Тюляндина А. С. , Урманчеева А. Ф. , Хохлова С. В.
Published: December 2023

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Злокачественные немеланоцитарные опухоли кожи (базальноклеточный рак кожи, плоскоклеточный рак кожи, карцинома Меркеля)
Authors: Утяшев И. А. , Орлова К. В. , Зиновьев Г. В. , Трофимова О. П. , Петенко Н. Н. , Назарова В. В. , Мудунов А. М. , Крамчанинов М. М.
Published: December 2023

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Саркомы мягких тканей
Authors: Егоренков В. В. , Бохян А. Ю. , Конев А. А. , Нестерова А. И. , Тарарыкова А. А. , Тюляндина А. С. , Шарабура Т. М. , Шелехова К. В. , Феденко А. А.
Published: December 2023

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Рак анального канала и кожи перианальной области
Authors: Гордеев С. С. , Бесова Н. С. , Мамедли З. З. , Рыбаков Е. Г. , Федянин М. Ю. , Черных М. В.
Published: December 2023

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Рак тонкой кишки и ампулы Фатерова сосочка
Authors: Ледин Е. В. , Лядов В. К. , Мороз Е. А. , Трякин А. А. , Черных М. В.
Published: December 2023

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Мелкоклеточный рак легкого
Authors: Чубенко В. А. , Бычков М. Б. , Деньгина Н. В. , Кузьминов А. Е. , Сакаева Д. Д. , Семенова А. И.
Published: December 2023

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Заместительная ферментная терапия при раке поджелудочной железы
Authors: Сытов А. В. , Зузов С. А. , Кукош М. Ю. , Лейдерман И. Н. , Потапов А. Л. , Хотеев А. Ж. , Кучерявый Ю. А.
Published: December 2023

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Экстравазация противоопухолевых препаратов
Authors: Буйденок Ю. В. , Обухова О. А.
Published: December 2023

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Инфузионные реакции
Authors: Орлова Р. В. , Жабина А. С. , Иванова А. К. , Наталенко К. Е. , Телетаева Г. М.
Published: December 2023

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Диагностика и лечение фебрильной нейтропении
Authors: Сакаева Д. Д. , Борисов К. Е. , Булавина И. С. , Когония Л. М. , Курмуков И. А. , Орлова Р. В. , Шабаева М. М.
Published: December 2023

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Кардиоваскулярная токсичность
Authors: Виценя М. В. , Агеев Ф. Т. , Орлова Р. В. , Полтавская М. Г. , Потиевская В. И.
Published: December 2023

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Loneliness and depression levels as risk factors of pain in geriatric prostate cancer patients
Authors: CICI Remziye , YILMAZEL Gulay , AYAZ Nur Pınar
Published: December 2023

BackgroundProstate cancer is the most prevalent malignancy among men, and psychological symptoms may affect many patients. Although much work has been carried out on loneliness, depression, and pain in geriatric prostate cancer patients, far less research has examined their associations. Therefore, the present study explored the association of loneliness and depression with pain in geriatric prostate cancer patients.
MethodsA cross-sectional study was conducted involving 83 patients between the ages of 60 and 74 years, who were diagnosed with prostate cancer and were close relatives of students studying at a health sciences university. Data were collected with the Loneliness Scale for the Elderly, Beck Depression Inventory, and Numerical Rating Scale. The duration of prostate diagnosis was evaluated according to patient files. Simple and multiple logistic regression analyses were used to analyze the data.
Results It was determined that the median age of the individuals included in the study was 66 years, and the median pain duration of these patients was two years. Severe pain was found in 62.7%, loneliness in 61.4%, and depression in 68.7% of the patients. Duration of diagnosis, loneliness, and depression were significantly associated with pain intensity. Depression increases the risk of pain intensity 3.41 times among patients (aOR=3.41;95% C.I.: 3.07-8.16; p=0.038)
ConclusionIt was determined that duration of diagnosis, loneliness, and depression levels were risk factors for pain intensity in geriatric prostate cancer patients. Developing interventions for patients' mental states in rehabilitation studies may help alleviate the severity of pain.
Correlation of angle kappa with biometry and higher-order aberrations of cataract patients at Prof. Ngoerah Hospital Ophthalmology Clinic
Authors: Siska Siska , Suryaningrum I Gusti Ayu Ratna , Evani Saphira
Published: December 2023

Background Advancements in ophthalmic surgery now hinge on intricate interplays among ocular parameters. Angle kappa, measuring deviation between visual and pupillary axes, is crucial, especially in refractive procedures with multifocal intraocular lens implants. The research aimed to correlate angle kappa with biometry and higher-order aberrations (HOA) to enhance surgical outcomes among adult cataract patients at Prof. Ngoerah Hospital Ophthalmology Clinic, Denpasar, Bali.
MethodsThis cross-sectional study included 29 male and female cataract patients aged 18-80 years, without prior treatment. All patients had a basic examination that included testing of visual acuity using Snellen chart, autorefractometer, measurement of ocular pressure using non-contact tonometry, and slit-lamp examination for cataract grading. Patients who met the inclusion criteria were then examined for biometry (axial length, spherical equivalent, white-to-white distance, anterior chamber depth) using Nidek AL Scan and for angle kappa and HOA using OPD scan III.
ResultsData from 50 eyes of 29 subjects (15 females and 14 males) were analyzed. The mean age of the subjects was 60.6 ± 12.5 years. Age and spherical equivalent had positive correlation with angle kappa (r =0.104, r=0.213), but the correlation was not statistically significant. In this study, interestingly angle kappa was not significantly correlated with HOA, AXL, WTW, and ACD (r = -0.050, r = -0.192, r = -0.104, r = -0.195, p >0.05).
ConclusionIn conclusion, angle kappa may increase with age and spherical equivalent. Further study with larger sample size is required.
Secretome hypoxia-mesenchymal stem cells decrease tumor necrosis factor-α and interleukin-18 in kidney of type 2 diabetes mellitus model rats
Authors: Irawan Risky Chandra Satria , Putra Agung , Setyo Trisnadi , Ghaisani Shabrina Syifa , Hidayah Nurul
Published: December 2023

Background Type 2 diabetes mellitus (T2DM) is a chronic disease that affects millions of people worldwide and associated with an increased risk of kidney damage caused by prolonged inflammation. Secretome hypoxia- mesenchymal stem cells (SH-MSCs) have been investigated as a potential therapy for kidney inflammation in T2DM, due to their immunomodulatory properties and ability to promote tissue repair. In this study, we investigated the effects of SH-MSCs on tumor necrosis α (TNF-á) and interleukin-18 (IL-18) in the kidney of the T2DM model rats.
MethodsA post-test-only control group involving 24 male Wistar rats. The rats were treated with a high-fat diet (HFD) for 4 weeks and streptozotocin-nicotinamide with sucrose solution for 5 days to induce T2DM animal models. Rats were randomly divided into four groups: healthy, control, and groups treated with SH-MSCs T1 and T2, with doses of 250 µL and 500 µL, respectively. TNF-α and IL-18 gene expression was measured by real time polymerase chain reaction (RT-PCR). One Way ANOVA and post-hoc LSD tests were used to determine the significant difference against all groups based on their quantitative measurement.
ResultsAdministration of the SH-MSCs at a dose of 500µL (T2) was able to significantly reduce TNF-α and IL-18 gene expression when compared to control (T2DM rat without treatment) (p<0.05), but not significantly when compared to healthy and SH-MSC at a dose of 250µL (T1) group (p >0.05).
ConclusionThis study demonstrated that the SH-MSCs decreased the levels of proinflammatory cytokines TNF-α and IL-18 gene expression in the kidney of T2DM model rats.
Actual civilian uas software and communications information security problems
Authors: Кузьмин А.Р. , Савельев М.Ф.
Published: December 2023

Статья продолжает цикл публикаций, посвященных информационной безопасности беспилотных авиационных систем. Целью настоящей статьи является анализ векторов атак на программное обеспечение и каналы связи беспилотных авиационных систем. Кроме того, проводится обзор методов защиты от подобных атак. При проведении исследований применялись методы контент-анализа и эксперименты с коммерческими беспилотными авиационными система доступных для гражданских пользователей. В результате был разработан систематизированный перечень атак на программное обеспечение и каналы связи.

With this article, the authors continue the series devoted to the information security of UAS. The purpose of this article is to analyze attack vectors on UAS software and communication channels. In addition, the authors reviewed methods of protection against such attacks. In their work, the authors applied content analysis methods and experiments with real commercial unmanned aerial systems available to civilian users. As a result, the authors have developed a systematic list of attacks on software and communication channels, presented in the form of tables in this article.
A lgorithms for constructing a system of comparison andestimates of the Lyapunov vector function
Authors: Хань Л.В.
Published: December 2023

Цель работы – на основе векторной функции Ляпунова и принципа сравнения построить алгоритмы и сформировать системы сравнения для непрерывных и дискретных линейных уравнений, описывающие сложные динамические системы. Изложены методы декомпозиции сложных динамических систем на подсистемы с линейными связями. С помощью таких методов процесс исследования сложных систем был упрощен. В ходе исследования также были разработаны подробные алгоритмы построения системы сравнения для непрерывных и дискретных объектов сложных систем. На основе теоремы Н.Н. Красовского рассмотрены оценки векторной функции Ляпунова и сформированы условия устойчивости сложных динамических систем. Разработанные алгоритмы поддерживают вычисление векторной функции Ляпунова и построение системы сравнения для непрерывных и дискретных объектов сложных динамических систем. Это является основой для оценки устойчивости системы и влияния линейных связей на устойчивость системы. Кроме этого, на основе этих алгоритмов (децентрализации сложных систем и построения системы сравнения) реализован синтез управления сложных динамических систем. В работе использованы алгоритмы для анализа устойчивости электроэнергетического объединения.

The purpose of research-based on the Lyapunov vector function and the comparison principle, algorithms were developed and comparison systems were formed for continuous and discrete linear equations that describe complex dynamic systems. In this work, methods for the decomposition of complex dynamic systems into subsystems with linear connections were presented. With the help of such methods, the process of studying complex systems was simplified. In the course of the research, detailed algorithms for constructing a comparison system for continuous and discrete objects of complex systems were also developed. Then, based on N.N. Krasovsky, an assessment of the Lyapunov vector function was considered and conditions for the stability of complex dynamical systems were formed. The developed algorithms support the calculation of the Lyapunov vector function and the construction of a comparison system for continuous and discrete objects of complex dynamic systems. This is the basis for assessing the stability of the system and the influence of linear relationships on the stability of the system. In addition, on the basis of these algorithms (decentralization of complex systems and the construction of a comparison system), the synthesis of control of complex dynamic systems is implemented. In this work, algorithms have been used to analyze the sustainability of an electric power pool.
Üst ölçekli planlama kapsamında Türkiye’deki Akdeniz Ekolojik Bölgesi ormanlarında karbon tutumu
Authors: PAMUKÇU ALBERS Pınar , BALKIZ Özge , ÇAĞLAYAN Semiha Demirbaş , BUCAK ONAY Tuba , ÇALIŞKAN Bilgehan Kaan , ÜLKER Elif Deniz , BİLGİN Gelincik Deniz , LİSE Yıldıray , ZEYDANLI Uğur S. , ÖZDEMİR Eray
Published: December 2023

Üst ölçekli planlama kapsamında orman ekosistemlerinde karbon tutumunun hesaplanması ve değerlendirilmesi, ormancılık faaliyetlerinin sürdürülmesi ve izlenmesi açısından önemlidir. Sürdürülebilir ve karbon odaklı ormancılık faaliyetleri karbon tutumunun düşük olduğu alanlarda, doğal ekosistem yapısına zarar vermeden karbon tutumunu artırmakta ve sera gazlarının azaltımına ilave katkı sağlamaktadır. Bu çalışmada Türkiye’nin Akdeniz Ekolojik Bölgesi’ndeki ormanlar için mevcut karbon tutumu, meşcere hacim değerleri ve uluslararası kabul görmüş katsayılar kullanılarak hesaplanmış ve haritalandırılmıştır. Çalışmada (1) orman idari sınırları için yapraklı ve ibreli ağaç türlerinin hektardaki ortalama karbon stok değerleri, (2) tüm bölgedeki yapraklı (saf ya da yapraklı ağaç türü ağırlıklı) ve ibreli (saf ya da ibreli ağaç türü ağırlıklı) meşcereler için hektardaki ortalama karbon stok değerleri, (3) kızılçam [Turkish red pine (Pinus brutia Ten.)] ve karaçam [black pine (P. nigra Arnold)] için çağ ve kapalılığa göre hektardaki ortalama biyokütle karbon stok değerleri hesaplanmıştır. Orman İşletme Şefliklerindeki orman meşcere türlerine göre ortalama toprak üstü biyokütle karbon stoku normal kapalı ibreli meşcereler için 36,12 ton C/ha ve normal kapalı yapraklı meşcereler için 20,13 ton C/ha’dır. Kızılçam için Çzde3 ve Çze3 meşcereleri ve karaçam için Çkde3 ve Çke3 meşcereleri en yüksek karbon tutumunu sağlamaktadır. Bu çalışmanın sonuçları, ekosistemlerin doğal yapısının da gözetilerek karbon stoku (depolaması) açısından ağaç türü seçiminde ve silvikültürel uygulamaların belirlenmesinde kullanılabilecektir. Bunun dışında meşcerede baskın olmayan türlerin karbon stok potansiyeli ilk kez bu çalışmada değerlendirilmiştir. Bu bilgi, bu türlerin karışımlarda korunmasını destekleyecektir. Son olarak, karbon yönetiminde yutak alanların ve karbon tutumunun artırılmasına yönelik çalışmaların artırılması ve önlemlerin alınması ya da sorunlara müdahale edilmesi gibi faaliyetlerde şeflikler arasındaki meşcere karbon stok farklarının gözetilmesini de sağlayacaktır.
The Relationship between the Fear of Missing Out (FoMO) and Social Media Use in Articulating Islamic Identity among Muslim Millennials
Authors: Ginting Elisa Br , Suwarjo Suwarjo , Lumbanbatu Johannes Sohirimon , Sihotang Din Oloan
Published: December 2023

Current technological developments have both positive and negative impacts. One of the negative impacts of excessive use of social media is that it can lead to addiction, cyberbullying, and fear of missing out (FoMO). It can even erode one's identity, as it is influenced by widely circulated videos on social media. The purpose of this research is to analyze the relationship between FoMO, problematic use of social media, and expressions of Islamic identity. The FoMO scale, social media disorder scale, and Instagram Islamic identity scale were used as measuring tools in this research. A quantitative approach was employed, using multiple analyses, which revealed that both FoMO and problematic use of social media contribute simultaneously to the expression of Islamic identity. The subjects of this research were 177 Indonesian millennial Muslims who actively participated in the Instagram migration movement. Problematic use of social media and expression of Islamic identity had an effective contribution of 40.6% (36.7% from social media use and 3.9% from FoMO). Additionally, we found that questionable social media use had a significant correlation with the articulation of Islamic identity, while FoMO itself had no correlation with it. These results can serve as a basis for future research on the expression of religious identity on social media and the development of interventions to address excessive social media use.
Evaluation of polypus growth among fecal immunochemical test positive patients
Authors: Hyder Chowdhury S. , Uddin Azim , Jalal Tanvir , Karim Saiyeda S. , Taher Abu , Nahar Kamrun , Naznin Kazi N. , Hossain Shahadat
Published: December 2023

Background: Colorectal cancer is a difficult clinical condition to treat all over the world. Adenomatous polyps are thought to be cancer precursors. A colonoscopy is required to detect and confirm ulcerative colitis mucosal healing. Different screening procedures, including as colonoscopy, fecal immunochemistry test (FIT), guaiac fecal occult blood test (gFOBT), computed tomography (CT) colonography, and others, are used to detect polyps or ulcers early. Although the gold standard colonoscopy serves both diagnostic and therapeutic purposes, the FIT can identify advanced adenoma or established cancer, as well as the mucosal condition of ulcerative colitis. The FIT is a less costly approach for detecting colonic disease that is appropriate for our demographic. The aim of the study was to observe the type of polypus growth among FIT positive patients.
Methods: This observational cross-sectional study was conducted at the department of colorectal surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. The study duration was 1 year, from July 2019 to August 2020. At the initial stage, a total of 510 participants were selected among the patients attending the outdoor department of BSMMU colorectal surgery following the inclusion and exclusion criteria.
Results: The male: female ratio was 1.7:1 in our study. 48.28% were from the age group of 50-59 years. The most common clinical presentation or symptom among the participants was constipation, observed in 81.03% of cases. 39.66% of the participants had abdominal pain, 32.76% had rectal mucus discharge, 12.07% had observed changes in their bowel movement, while 6.90% had a lack of appetite. Among the participants, 42 had pedunculated polyp, while 16 had sessile polyps. A total of 55.17% had non-advanced pedunculated polyp, 22.41% had non-advanced sessile polyp, 17.24% had advanced grade pedunculated polyp, while the remaining 5.17% had advanced grade sessile polyp. Histopathological findings revealed that 44.83% of the participants had tubular adenoma with low grade dysplasia (LGD) among the non-advanced pedunculated polyps’ cases, 17.24% had tubular adenoma with LGD among the non-advances sessile cases. Among the advanced pedunculated polyps’ cases, 6.90% had tubular adenoma with high grade dysplasia (HGD), 3 (5.17%) had villous adenoma with dysplasia, and 2 (3.45%) had tubulovillous with dysplasia. Among the 3 advances sessile polyps cases, 3.45% had tubular adenoma with HGD, while 1 patient had malignancy.
Conclusions: It was observed that FIT positive patients had a higher frequency of pedunculated polyps, specifically advanced pedunculated polyps. Both sessile and pedunculated polyps had a high prevalence among patients aged between 50-59 years.
Outcome of spillage of gallbladder contents during laparoscopic cholecystectomy: a case control study
Authors: Amin Ruhul , Ovi Mir Rasekh Alam , Nasrin Shamima
Published: December 2023

Background: Bile leakage due to many causes are common during laparoscopic cholecystectomy (LC). We sought to determine prospectively the incidence of gallbladder perforation during LC and to ascertain whether or not spillage of gallbladder contents resulted in overt complications. 
Methods: Between July 2013 to December 2013, 120 patients underwent LC participated in this study. All patient’s pre-operative ultrasonogram reports were collected. Of the 120 patients, 53 patients had spillage of gallbladder contents due to intra operative perforation. Per operative data were collected. Bile sample of all the hundred twenty patients were sent for culture and sensitivity.  All patients were followed-up for two weeks post operatively.
Results: Compared with those without GB perforation, there was a larger percentage of men (41.5%) in the spillage group. Spillage also common in patients having acute cholecystitis (32%), pigment stones (26 out of 38 pigment stone), multiple number of stones (77.3%), positive bile culture (30%). Most common complication was port site wound infections (3 in no. out of 53). There was no difference in post-operative amount or type of analgesia administered, duration of post-operative hospital stays in between two groups.
Conclusions: Perforation of gallbladder and intra peritoneal spillage of bile and stones during LC is still a common incident, but are not associated with undesirable events and are not indications for conversion. When spilled bile is properly aspirated by peritoneal irrigation the operative and post-operative courses are similar to those of patients without spillage of gallbladder contents.
Surgical management of post hemorrhoidectomy benign anal stenosis - an experience of eleven patients
Authors: Chovatia Naresh K. , Bhuva Bhavin A. , Sharma Praveen K. , Pancholi Mukesh M.
Published: December 2023

Anal stenosis is a serious but fortunately rare complication of anorectal surgical procedures. It has been shown that approximately 90% of anal stenosis develops after hemorrhoidectomy, and 1.5-3.8% of all hemorrhoidectomies. The surgical methods such as stricture release, sphincterotomy and advancement flap are common techniques to repair anal stenosis. This is a retrospective observational study of 11 patients with benign anal stenosis managed surgically from January 2017 to April 2022. A total of 11 patients (nine males and two females), mean age 45.6 years (range- 33-90 years), underwent various surgical procedures like partial lateral internal sphincterotomy (PLIS) (n=04), V-Y flap anoplasty (n=03) and diamond flap anoplasty (n=04) with PLIS in both types of anoplasties as an associated procedure. After follow up period of two months to three years, all patients of PLIS had 100% healing rate, V-Y flap anoplasty had 66% healing rate with re-stenosis in one patient and diamond flap anoplasty had 100% healing rate with no restenosis. In moderate to severe anal stenosis and failed conservative management, various anoplasty techniques can be used with lateral sphincterotomy with good results, especially diamond flap anoplasty.
An unusual case of tubercular liver abscess presenting as pericardial effusion
Authors: K. B. Vismaya , Rashid Rihan
Published: December 2023

Tropical nations like India frequently have liver abscess. They are typically amoebic or pyogenic abscesses. It can sporadically be a sign of hepatic tuberculosis (TB). Hepatic tuberculosis should be suspected in cases where the patient doesn’t present with typical complaints of pyogenic/amoebic abscess without response to commonly used antibiotics. Pyogenic/amoebic liver abscesses show the rare complication of rupture into the pericardium, especially if the abscess is left sided. However, a tubercular pericardial effusion presenting with rupture into the pericardium has rarely been reported. We present to you a case of tubercular pericardial effusion in a known diabetic patient secondary to ruptured liver abscess presenting to the emergency department with chief complaints of breathlessness, chest pain and bilateral pedal edema.
CULTURA MARCIAL CHINESA E A DIDÁTICA EM HISTÓRIA: COSTUMES E A PRÁTICA DO KUNG FU NO BRASIL
Authors: Aguiar José Otávio , Felix Alex Souza , Gomes Márcia Maria Costa
Published: December 2023

Este ensaio apresenta uma discussão sobre a temática da cultura marcial chinesa e a didática em História, a partir das oficinas de extensão de Kung Fu. A prática da Arte Marcial chinesa (Kung Fu/Wushu) representa um conjunto de técnicas de luta e defesa pessoal e simboliza um dos pilares da cultura chinesa, embebido de elementos filosóficos, estéticos/artísticos e históricos. Nosso objetivo se constituiu de justificativas centrais como: fortalecer a formação dos graduandos em História em torno da cultura, formação histórica, arte e prática marcial chinesa, proporcionando ampliação de conhecimentos; contribuir para aproximação cultural entre Brasil e China, junto à comunidade acadêmica e à extensionista; disseminar a prática do Kung Fu, enquanto arte marcial chinesa e prática saudável para o corpo e mente, e, por fim, estimular uma didática da história que extrapole a leitura, criando pontes entre a interdisciplinaridade, a prática física e a pesquisa em história. A metodologia utilizada baseou-se na pesquisa bibliográfica, fornecendo material teórico sobre a temática e a prática do Kung Fu, que se deu no decorrer das oficinas ofertadas pelo Projeto de Extensão da UFCG nas unidades do IFPB-Campus Campina Grande. No contexto geral, observamos, que as oficinas teóricas/práticas de Kung Fu trouxeram à tona a história, os costumes e a arte marcial chinesa de forma didática.  Os resultados aqui descritos revelam que a prática da arte marcial Kung Fu foi acompanhada de melhoramento na flexibilidade, na coordenação motora, na condição cardiorrespiratória, na capacidade de percepção espacial e de equilíbrio no decorrer das oficinas.
LIVES DE MATEMÁTICA: POSSIBILIDADES DE APRENDIZAGEM ATRAVÉS DO YOUTUBE
Authors: Santos William
Published: December 2023

Em meio ao isolamento social ocasionado pela pandemia, as redes sociais representaram um papel fundamental para a manutenção das relações entre as pessoas e no âmbito educacional, para a criação de um ambiente de aprendizado inovador. Neste cenário, as lives do Esquenta Encontro Cajazeirense de Matemática (ECMAT) disponibilizadas através da plataforma do Youtube possibilitaram a alunos e profissionais da área de Matemática um ambiente de formação continuada e de difusão do conhecimento. Para tanto, este artigo tem o objetivo de divulgar os resultados obtidos pelas lives realizadas no ano de 2021.
Chrześcijańska koncepcja stworzenia i jej implikacje w perspektywie problematyki „Deus absconditus – Deus revelatus”
Authors: Słomka Marek
Published: December 2023

W świetle niektórych tez, wywodu i argumentacji zawartych w najnowszej książce Jacka Wojtysiaka Między ukryciem a jawnością. Esej z filozofii religii i teologii filozoficznej (2023) w niniejszym artykule prezentuję ważne elementy chrześcijańskiej koncepcji aktu stwórczego i relacji Bóg-–świat oraz wynikających z tego konsekwencji dla wyrażania istotnych składników doktryny religijnej. Argumentuję, że nie jest możliwe stworzenie świata z (względną) autonomią oraz (względną) ludzką wolnością, w którym nie ma zła naturalnego i zła moralnego. W tym kontekście podkreślam wagę aspektowego i racjonalnego ujęcia relacji Stwórca–stworzenie oraz znaczenie teorii kenozy, w której akt kreacji przedstawiany jest jako swoiste samoograniczenie Boga.
Communicating Religious Content and the Reception of Meanings in Social Space: The Series Saviour Under the Birches
Authors: Abassy Małgorzata
Published: December 2023

The article contains an analysis of the content of the 12-part series entitled Saviour under the Birches. The main idea of the director, Leonid Eydlin, to show the audience the ordinary side of life, however related to faith and the search for the right decisions in difficult situations, was confronted with the comments of the viewers, posted under subsequent parts of the series on youtube.com, kinopoisk.ru, otzovik.com, and kino-teatr.ru. The source material is treated as a cultural text in the Lotman sense. Content analysis and the hermeneutic method, taking into account contexts, are the research methods. Analyses of the content of the series made it possible to show that Eidlin’s intention to show Orthodoxy as a religion culture, based on the realities of everyday life of an ordinary man, preoccupied with material problems but also searching for the meaning of the problems affecting him in the non-material world. The analysis of Internet users’ comments, in turn, showed that they identify their problems with those experienced by the characters in the series.
Dostrzegać szersze związki. O Filozofii społecznej Stanisława Janeczka i Anny Starościc
Authors: Hułas Maciej
Published: December 2023

Filozofia społeczna wypełnia niszę „rynku akademickiego” pierwszoligową naukowością i ustawia soczewki oglądu porządku społeczno-instytucjonalnego, który jest zakorzeniony w tradycji, odzwierciedla teraźniejszość i jest akceptująco otwarty na przyszłość. A wszystko dzięki realizmowi chrześcijańskiej tradycji filozofii i paradygmatowi prawdy przyjętym jako miary poprawnego widzenia i wnioskowania. Porządkują one zróżnicowane stanowiska autorów, przypominając, że bez względu na to, jak bardzo usiłuje się ustalać prawdziwości na drodze różnego rodzaju porozumień, istnieje coś takiego jak prawda niezależna od konsensów. Jej negowanie dezorientuje aksjologicznie społeczeństwa i prowadzi do degeneracji instytucji będących cywilizacyjnymi osiągnięciami Zachodu. Filozofia społeczna integralnie ujmuje złożoną rzeczywistość instytucji w perspektywie ich inherentnych celów; nie tylko przypomina, czym są i jak funkcjonują, ale też osadza je w ich szerszych kontekstach i genealogicznych ciągłościach.
Sociological Research in Pastoral Theology. Objectives and Execution
Authors: Kiełb Dominik
Published: December 2023

The interdisciplinarity of scientific discourse is a common phenomenon in modern times. What is more, it is postulated that analyses conducted as part of theological research should take into account the achievements of other fields of knowledge and use the research methods and techniques they have developed. This is primarily because theology, and especially pastoral theology, must refer to other sciences, especially sociology, to solve certain research problems. Using sociological methods and techniques primarily requires diagnosing the current pastoral situation. With these methods, first credible conclusions and then realistic postulates can be formulated. The formulated postulates have a real value as they are based on confronting and verifying models, content, methods and forms used. The goal of this article is to present the main paradigms in the field of theology that require sociological research and then detailed sociological methods and techniques used in pastoral research. A specialist, technical knowledge of sociological measurements and praxeological interpretation of empirical data will be presented concerning the latter issue. Many studies in the field of pastoral theology require detailed sociological knowledge to create a research tool, select a research sample, perform research, and interpret its results.
Kitâbü’t-Tevhîd ve Kitâbü’t-Te’vîlât’ın Uyumu: Rü’yetullah Örneği
Authors: AVCI Metin
Published: December 2023

Rü’yetullah meselesi hicri birinci asrın sonlarında tartışılmaya başlanmış, Allah’ın görülmesinin imkânsızlığını savunan Mu‘tezile ile Allah’ın ahirette görüleceğini savunan Ehl-i Sünnet arasında süregelen bir tartışma olmuştur. Ehl-i Sünnet’in önemli temsilcilerinden Matürîdî’nin yaşadığı dönemdeki aktüel tartışma konuları arasında yerini alan bu meseleye, Mâtürîdî de kayıtsız kalmamış, bilakis Kitâbü’t-Tevhid ve Kitâbü’t-Te’vilat’ında konuya geniş yer vermiştir. Mu‘tezile’den kendi çağdaşı el-Ka‘bî’ye yönelttiği eleştiriler üzerinden meseleyi; ayet, hadis ve akıl süzgecinde detaylandırmış ve Allah’ın ahirette görülmesinin gerekli olup gerçekleşeceğini söylemiştir.

Mâtürîdî’nin rü’yetullah meselesini tahlil ederken her iki eserinde kullandığı argümanlar, delillerin sunumu vb. izlediği yöntem, bu eserler arasındaki mana ve ibare uyumunu ortaya koymakta, görüşlerin ve görüş sahibinin aynı kişi olduğuna işaret etmekte, her iki eserin sahibinin Mâtürîdî olduğunu göstermektedir. Bu uyum; Mâtürîdî’nin eserleriyle ilgili araştırmalar yapan bazı müsteşriklerin, eserler üzerinde oluşturdukları aidiyet şüphesini gidermektedir. Bu makalede, Mâtürîdî’nin sözü geçen her iki eserindeki rü’yetullah’a dair görüşleri; orijinalliği bozulmadan karşılaştırmalı olarak verilmiş, ibaredeki küçük farklılıklar da gösterilmiştir. Bu çalışma ile hem Mâtürîdî’nin meseleye dair görüşleri derli toplu bir arada sunulmuş hem de Kitâbü’t-Tevhid ve Kitâbü’t-Te’vilat’ın Matürîdî’ye ait olduğu ortaya konulmuştur.
Evzâî’nin İtikadî Yönü
Authors: BALCI Ali Osman , ÖNDER Murat
Published: December 2023

Fıkhî mezhepler içerisine dâhil edilen ve Şam merkezli bir mezhep olan Evzâîlik, özellikle Emevîler döneminde siyasi olarak desteklenerek yayılma fırsatı bulmuştur. Evzâî’nin görüşleri Emevîler tarafından desteklenmesinin bir sonucu olarak yayılma fırsatı bulmuştur. Hicrî II. asrın sonları itikadî konulardaki tartışmaların yoğun olarak yaşandığı yıllardır. Ehl-i Hadis grubuna dâhil edilen Evzâî, bu tartışmalara yeri geldikçe dâhil olarak kendi görüşlerini ortaya koymuştur. Siyasî anlamda Emevîlerce desteklenen Evzâîlik, Abbâsîler’in iktidarı ele geçirmesinden sonra deyim yerinde ise kaybolmaya yüz tutmuştur. Genel olarak itikadî konulardaki tartışmalara girmemeye ve bundan sakındırmaya yönelik söylemlerine karşın Evzâî, gereken durumlarda ortaya koyduğu görüşlerde Selef itikadına vurgu yaparak bunun dışına çıkmamaya gayret etmiştir.
Armut Islahındaki Güncel Gelişmeler
Authors: AYDINLI Melih , YILDIRIM Fatma
Published: December 2023

Meyve türleri içerisinde hem yetiştiricilik hem de ticari değer bakımından ön sıralarda bulunan armut (Pyrus spp), oldukça geniş bir coğrafyada ekonomik olarak yetiştirilmektedir. Diğer meyve türlerinde olduğu gibi armutta da tüketici istekleri, ekolojik koşullar ve yetiştiricilikte ortaya çıkan birtakım olumsuzluklar, ıslah programlarının başlatılmasını ve yeni çeşitlerin/anaçların geliştirilmesini zorunlu kılmaktadır. Her ne kadar armut ıslahının temeli 16. yüzyıla kadar uzansa da gerçek anlamdaki ıslah programlarının başlaması 20. yüzyıla denk gelmektedir. Beş ana karada Pyrus cinsine ait farklı türlerin yetiştirilebiliyor olması, oluşturulan ıslah programlarının amaçlarında değişikliklere yol açmaktadır. Bu çalışmada, yakın geçmişte gerçekleştirilen ve halen devam eden armut ıslah programları kıtalara ve ülkelere göre incelenmiş olup, ıslah amaçlarında oluşan değişiklikler belirtilmiştir. Ayrıca güncel ıslah programları kısaca tanıtılarak, programların durumu ve çıktıları hakkında bilgiler verilmiştir.
Lateral medullary infarction in a patient with Moyamoya disease associated with RNF213 variants: a case report
Authors: Roh Yoo Jeong , Lee Kee Ook , Kim Hyun Sook
Published: December 2023

Background: Moyamoya disease (MMD) is a rare cerebrovascular disease radiologically characterized by progressive bilateral occlusion of the distal portion of the internal carotid artery and compensating collaterals. Herein, we report a case of medullary infarction in a patient with MMD.Case Report: We present the case of a 54-year-old male with hypertension, hyperlipidemia, and unstable angina with sudden onset dysarthria and ataxia. Diffusion-weighted and T2-weighted images of magnetic resonance imaging showed a high-signal intensity lesion on the right lateral medulla, suggestive of acute infarction. Transfemoral cerebral angiography also demonstrated bilateral middle cerebral artery (MCA) occlusion. Testing of the ring finger protein 213 (RNF213) gene revealed a homozygous p.R4810K variant that was possibly associated with posterior circulation involvement.Conclusion: When the MCA is occluded in MMD, there is a possibility that medullary infarction may occur due to the mechanism of increased hemodynamic stress on the anastomotic posterior vessels.
Study of acute toxicity of a new drug “AOS” for the treatment of osteoporosis.
Authors: Mironov A. A. , Mamina N. Sh. , Voronin S. Ye. , Bayramov A. A.
Published: December 2023

Background. Osteoporosis is one of the most common diseases, which, along with myocardial infarction, stroke, cancer, and sudden death, occupies a leading place in the structure of morbidity and mortality of the population. Postmenopausal women are most vulnerable and are approximately 4 times more likely to be affected than men (80 % of all patients), and osteoporosis-related fractures are responsible for a significant increase in morbidity, disability, and mortality, especially in the elderly.

Objective. To study the acute toxicity of the new drug “Antiosteoporosis drug” (patent No. 02-04-16643/15-0 dated February 26, 2015) with a single intragastric administration to mature outbred rats of both sexes.

Design and methods. The study was conducted on outbred rats of both sexes according to protocol OECD 420, GOST 32296-2013. The development of a toxic effect was concluded based on behavioral tests, clinical examinations, changes in body weight, the results of pathomorphological examination of organ tissue and biochemical parameters of blood and urine.

Results. According to the results of the study, the tested drug was classified according to the active substance into category 5 according to the GHS classification (2000<LD50 (i/g)<5000 mg/kg). An assessment of the dynamics of body weight in experimental animals showed that a single intragastric administration of the test drug had no effect on this indicator. The study of individual behavior as part of the main study on the 14th day after a single intragastric administration of the test drug showed that a single intragastric administration of the test drug at a dose of 2000 mg/kg did not have a delayed effect on the general condition and indicative research activity of experimental animals. Autopsy and pathological examination of animals on the 15th day after a single intragastric administration of the test drug did not reveal the presence of any residual effects associated with the administration of the test drug. The tested drug did not have a local irritant effect on the injection site — the gastrointestinal tract. In all tests, the degree of change in indicators caused by the test drug was the same: there were no statistically significant differences in the recorded parameters between the test drug and the control group.
Northern State Medical University; Arkhangelsk Regional Children’s Clinical Hospital named after P. G. Vyzhletsov
Authors: Borovaya A. A. , Ulanova A. S. , Turabov I. A. , Mitrofanov V. A. , Kulikov A. S.
Published: December 2023

Intestinal cystous pneumatosis is a rare pathology in pediatric practice, accompanied by a nonspecific clinical picture, which greatly complicates the diagnosis. The literature describes isolated cases of the development of this condition in oncohematological patients of childhood. Intestinal cystous pneumatosis in them can be complicated by life-threatening conditions, and therefore the choice of the correct tactics for managing these patients significantly affects survival. This article describes 2 clinical cases when cystic pneumatosis of the intestine developed during the treatment of an oncological disease.