bluuebunny/crossref_metadata_2025 huggingface dataset:
History Of The Emergence And Development Of Scientific Societies In The Governor-General Of Turkestan
Authors:   Phd Researcher, National University Of Uzbekistan Tashkent, Uzbekistan, Nazarov Azizbek
Published: October 2020

Documents providing information on the results of scientific research conducted by scientific societies in Central Asia and adjacent regions are stored in the National Archives of Uzbekistan. Documents from the archives were purposefully used to disclose the content of the article. This article is devoted to the study of the history of scientific societies operating in the Turkestan region in the second half of the XIX - early XX centuries and their scientific research in the country. The article provides information on the emergence and activities of scientific societies in the Governor-General of Turkestan, the results of the efforts of active members to study the country, using archival sources.
Teologia umbandista
Authors: Carneiro João Luiz
Published: October 2020

O presente artigo tem como pretensão discutir a teologia umbandista calcada numa perspectiva de diversidade. Partindo desta cadeira relativamente nova no cenário acadêmico, as umbandas são apresentadas com as suas principais características, desde a formação histórica até os elementos que a constituem tomando como base autores que formaram o campo ou são formados em teologia.
Sabedorias botânicas
Authors: Rocha Yuri
Published: October 2020

As sociedades humanas acumulam conhecimentos sobre suas realidades de mundo no transcorrer do tempo, tanto as de tradução oral quanto as de tradição escrita. Esses conhecimentos incluem também as informações sobre as plantas e animais que estão em contato com essas sociedades e que por elas são utilizados de diferentes maneiras e finalidades. Desde as pinturas rupestres até os herbários do século XVII, esses conhecimentos seculares são registrados. Nas tradições orais, cujos conhecimentos passam de geração para geração pela oralidade e experiência do uso, as sabedorias botânicas têm sido estudadas pela ciência e registradas pela etnobotânica, em pesquisas realizadas junto a etnias indígenas e comunidades quilombolas, caiçaras, ribeirinhas e tradicionais e, também, nas religiões afro-brasileiras, sobre as várias utilizações que as plantas têm para essas comunidades.
Object-based grouping benefits without integrated feature representations in visual working memory
Authors: Chen Siyi , Kocsis Anna , Liesefeld Heinrich R. , Müller Hermann J. , Conci Markus
Published: October 2020

Visual working memory (VWM) is typically considered to represent complete objects—that is, separate parts of an object are maintained as bound objects. Yet it remains unclear whether and how the features of disparate parts are integrated into a whole-object memory representation. Using a change detection paradigm, the present study investigated whether VWM performance varies as a function of grouping strength for features that either determine the grouped object (orientation) or that are not directly grouping relevant (color). Our results showed a large grouping benefit for grouping-relevant orientation features and, additionally, a much smaller, albeit reliable, benefit for grouping-irrelevant color features when both were potentially task relevant. By contrast, when color was the only task-relevant feature, no grouping benefit from the orientation feature was revealed both under lower or relatively high demands for precision. Together, these results indicate that different features of an object are stored independently in VWM; and an emerging, higher-order grouping structure does not automatically lead to an integrated representation of all available features of an object. Instead, an object benefit depends on the specific task demands, which may generate a linked, task-dependent representation of independent features.
Analisis Kemampuan Literasi Matematis Siswa ditinjau dari Gaya Belajar
Authors: Allinda Hamidah
Published: October 2020

Penelitian ini didasarkan pada keingintahuan penulis pada peserta didik Madrasah Ibtidaiyah Ihyaul Ulum mengenai kemampuan literasi matematis peserta didik jika ditinjau dari gaya belajar Visual, Auditorial, dan Kinestetik (V-A-K). Sejauh mana pemahaman peserta didik mengenai soal cerita matematika dengan mencapai level dalam literasi matematis. Penelitian ini merupakan penelitian studi kasus (Case Study) dengan pendekatan kualitatif deskrptif. Instrumen yang digunakan yaitu angket gaya belajar dan tes kemampuan literasi matematika. Data yang ada lalu dianalisis dengan model Milles dan Huberman yaitu dengan mereduksi data, penyajian data, dan penarikan kesimpulan. Berdasarkan hasil analisis data dan memperhatikan rumusan masalah, diperoleh hasil sebagai berikut: 1) Kemampuan literasi matematis peserta didik dengan gaya belajar visual mampu mencapai  level 5 dengan memenuhi semua indikator pada level 5. 2) Kemampuan literasi matematis peserta didik dengan gaya belajar auditorial mampu mencapai level 5, akan tetapi dari ke 4 indikator pada level 5 hanya mampu dicapai 3 indikator saja. 3) Kemampuan literasi matematis peserta didik dengan gaya belajar kinestetik mampu mencapai level ke 4 dengan memenuhi 3 indikator.
Nilai Islam Wasathiyah-Toleran dalam Kurikulum Madrasah Aliyah Program Keagamaan
Authors: Abu Amar
Published: October 2020

Islam wasathiyah (moderat), merupakan Islam khas Indonesia yang sudah teruji oleh sejarah, dan menjadi inspirasi muslim internasional. Islam dan muslim Indonesia tetap menemukan momentumnya sebagai agama yang mengedepankan sikap-sikap moderat, inklusif, humanis, toleran dan damai, Islam wasathiyah adalah Islam khas Indonesia. Namun akhir-akhir ini, keunikan mulai bergeser. Sejumlah fakta tentang konflik dan kekerasan yang dilakukan oleh individu maupun kelompok dengan mengatasnamakan agama bahkan dengan dalih membela agama telah merusak kebhinekaan dan toleransi itu sendiri.  Madrasah Aliyah program keagamaan, selayaknya mempromosi-kan pendidikan Islam wasathiyah. Fokus tulisan ini hendak mengelaborasi sejauhmana toleransi sebagai ciri terpenting Islam wasathiyah menjadi tujuan diwujudkan dalam kurikulum  MA program keagamaan. Ternyata  kompetensi toleransi peserta didik lebih menekankan pada pemahaman dalam pemikiran dan keragaman keagamaan Islam, sedangkan toleransi dengan agama atau golongan di luar Islam sebatas penerimaan berbeda sebagai kehendak Tuhan, tanpa ada elaborasi mengenai dialog dan kerjasama dalam konteks sesama warga negara dalam kesedarajatan
The Two Sides of Video Games
Authors: Wang Boyu
Published: October 2020

With the progress of technology during the 21st century, video games have gradually replaced books and newspapers to become mainstream entertainment for many people. In the face of this emergence, reactions to this type of entertainment vary greatly and opinions surrounding the impacts are often polarized. Many believe that video games impact users negatively, leading to violent behavior and depression. On the contrary, others who support video games believe that players can become averse to violence and reduce stress levels. This research paper elaborates and compares two opposing views through example citation and discussion. The author compares video games to books, illustrates the similarities between the two, and the uniqueness of video games through evidence and demonstration. With supporting evidence, the author suggests that the effects of video game usage are not as negative as some imagine. Moreover, this research paper will illustrate the benefits of playing video games.
Aspectos terapéuticos del covid-19: evidencia científica sobre uso de anticoagulantes en estos pacientes
Authors: Pincay Rosales Tarquino Adrián , Caballero Pineda Boris Xavier , Parra Jiménez Manuel Roberto , Chávez Salazar Manuel Ricardo , Marin Pineda Melissa Katyuska
Published: October 2020

RESUMEN

Actualmente existen recomendaciones en cuanto a los enfoques terapéuticos en el caso de los anticoagulantes, dado los resultados positivos en varios hospitales en investigaciones experimentales.  Sin embargo, existe aún limitaciones sobre la patogenia de la enfermedad, muchos de procesos fisiopatológicos aún no tienen explicación, por lo tanto, el control y tratamiento se complican en casos graves de pacientes que presentan factores de riesgos, no obstante ya es conocido el COVID-19 y su severidad en adultos mayores con presencia de enfermedades crónicas se asocian a una alta morbimortalidad. Uno de esos procesos fisiopatológicos son las alteraciones cardiovascular, la tromboembolia que se da como consecuencia de la activación de los procesos de coagulación que aún no se ha podido determinar porque sucede. Se pretende buscar y analizar la información publicada durante el 2020 y precisa respecto a la terapéutica de Covid-19 con énfasis en anticoagulantes en pacientes covid-19. Algunas investigaciones refieren que existe una relación entre anticoagulantes y con una mejor supervivencia hospitalaria entre los pacientes con COVID-19, tanto dentro como fuera de la unidad de cuidados intensivos, los pacientes que recibieron anticoagulantes tenían marcadores inflamatorios más altos en comparación con los pacientes no tratados con anticoagulantes. Demuestra que los anticoagulantes tomados por vía oral, subcutánea o intravenosa pueden desempeñar un papel importante en el cuidado de los pacientes con COVID-19, y estos pueden prevenir posibles eventos mortales asociados con el coronavirus, incluidos ataque cardíaco, accidente cerebrovascular y embolia pulmonar, pero, cada caso debe ser evaluado de forma individual, considerando los riesgos- beneficios ,es importante seguir evaluando la efectividad de la terapia antitrombótica: antitrombótica oral, heparina subcutánea y heparina intravenosa a través de ensayos clínicos prospectivos.
Unravelling the effect of viscous fiber on food intake: A review of studies
Authors: Hadri Zouheyr
Published: October 2020

Ingesting a diet rich in soluble and/or viscous dietary fiber induces stimulation of satiety by stimulation of enterodigestive peptides. The goal of the present review was to show the impact of soluble and viscous fibers on the depression of energy intake. Then, to investigate the existence of several parameters involved in the stimulation of the anorexigenic effect such as; the maintenance of viscosity, gastric emptying and the secretion of enterodi-gestive peptides. With the help of clinical studies, guar gum, alginate, β-glucan, pectins and psyllium were chosen in order to better understand their mechanisms of action on stimulation of satiety and depression of food in-take. Guar gum and alginate forms viscosity under acid environment which lead to slows down the gastric emptying and transit gastrointestinal. This effect promotes the contact between nutrient and bowels leading to increase the sensation of satiety and decrease of energy intake. β-glucan increase the secretion of anorexigenic hormone PYY. While, pectin and psyllium increase the secretion of PYY and GLP-1.
Pathogenic Effects of F8 Gene Mutations Identified in the Algerian Population Using In Silico Methods
Authors: Meriem Abdi , Feriel Terbeche , Sarah Mahmoudi , Faouzia Zemani
Published: October 2020

Since the publication of the F8 gene sequence, a large number of F8 gene mutations has been identified. These mutations are responsible for causing hemophilia A, an inherited bleeding disorder resulting from a reduced or absence of the coagulant FVIII protein activity. In the present study, we aimed to analyze the structural and functional impact of novel F8 gene mutations, previously identified in the Algerian population, through several in silico methods : HSF, ESE Finder, I-Mutant 2, SIFT, Polyphen 2, Align GVGD, ConSurf and Project Hope. Our analysis showed that the splice site mutation c.5219+1G>T is responsible of exon 14 skipping which cause the deletion of the protein B domain. Concerning the missense mutation c.200A> C (p.Lys48Thr), physicochemical changes between Lysine and Threonine were predicted to have deleterious effects on both structure and function of the protein. The c.200A> C introduces a neutral residue to the protein structure which could be responsible of hydrogen bonds loss causing improper folding of the FVIII protein. The novel missense mutation c.2189G> A (p.Cys711Tyr) is responsible of the rupture of the disulfide bridge (Cys630-Cys711) causing a FVIII protein destabilization. This study demonstrates the effectiveness of the combined use of several in silico methods to assess the deleterious effects of novel mutations. In silico methods, despite being useful in providing informations about effects of mutations, can also serve as a first-pass filter for experimental studies.
Heliospheric Maps from Cassini INCA Early in the Cruise to Saturn
Authors: Westlake J. H. , Mitchell D. G. , Gkioulidou M. , Dialynas K. , Cohen I. J. , Krimigis S. , Decker R. B. , Turner D. L. , Higginson A. K. , Clark G. , Paranicas C. P.
Published: October 2020

We present new energetic neutral atom (ENA) maps from the Ion and Neutral Camera (INCA) instrument on Cassini from the year 2000, prior to Cassini’s encounter with Jupiter. These maps are the first produced for the year 2000 and are the only maps with comprehensive spatial coverage from the peak of solar cycle 23. These ENA maps span the energy range from 5.2 to 55 keV covering the pickup to suprathermal energy range. These maps represent a novel glimpse into the influence of the solar cycle on the structure of the outer heliosphere, specifically on the heliosheath where pickup and suprathermal ions dominate. The observations are consistent with the picture of the heliosheath from previous observations by the Cassini, Interstellar Boundary Explorer (IBEX), and Voyager missions. These maps have some consistent spatial features to maps produced by Cassini during solar cycle 24 such as reduced intensities in the mid-latitude basins. These maps also have distinct spatial features such as enhanced intensities at the poles and reduced intensities at the low-latitude flanks. These maps do not indicate a strong intensity increase in the regions adjacent to the nose and also show an intensity increase in the regions adjacent to the tailward direction.
Neon Cluster Formation and Phase Separation during White Dwarf Cooling
Authors: Caplan M. E. , Horowitz C. J. , Cumming A.
Published: October 2020

Recent observations of Galactic white dwarfs (WDs) with Gaia suggest there is a population of massive crystallizing WDs exhibiting anomalous cooling—the Q branch. While single-particle 22Ne sedimentation has long been considered a possible heat source, recent work suggests that 22Ne must separate into clusters, enhancing diffusion, in order for sedimentation to provide heating on the observed timescale. We show definitively that 22Ne cannot separate to form clusters in C/O WDs using molecular dynamics simulations, and we further present a general C/O/Ne phase diagram showing that strong 22Ne enrichment is not achievable for 22Ne abundance ≲30%. We conclude that the anomalous heating cannot be due to 22Ne cluster sedimentation and that Q branch WDs may have an unusual composition, possibly rich with heavier elements.
Fermi/GBM View of the 2019 and 2020 Burst Active Episodes of SGR J1935+2154
Authors: Lin Lin , Göğüş Ersin , Roberts Oliver J. , Baring Matthew G. , Kouveliotou Chryssa , Kaneko Yuki , van der Horst Alexander J. , Younes George
Published: October 2020

We present temporal and time-integrated spectral analyses of 148 bursts from the latest activation of SGR J1935+2154, observed with the Fermi/Gamma-ray Burst Monitor from 2019 October 4 through 2020 May 20, excluding an ∼130 s segment with a very high burst density on 2020 April 27. The 148 bursts presented here are slightly longer and softer than bursts from earlier activations of SGR J1935+2154, as well as from other magnetars. The long-term spectral evolution trend is interpreted as being associated with an increase in the average plasma loading of the magnetosphere during bursts. We also find a trend of increased burst activity from SGR J1935+2154 since its discovery in 2014. Finally, we find no association of typical radio bursts with X-ray bursts from the source. This contrasts the association of FRB 200428 with an SGR J1935+2154 X-ray burst, which is to-date unique among the magnetar population.
Flap Method is Better Than the Tubularized Incised Plate Method for the Surgical Treatment of Distal Hypospadias
Authors: Duarsa Gede Wirya Kusuma , Lawanto Samuel Denny , Oka Anak Agung Gde , Santosa Kadek Budi , Yudiana I Wayan , Tirtayasa Pande Made Wisnu , Pramana Ida Bagus Putra , Ryalino Christopher
Published: October 2020

BACKGROUND: Urethroplasty techniques generally can be divided into two methods, the flap method (Mathieu and Onlay Flap) and no flap with tubularized incised plate (TIP) urethroplasty method. Complications are common after urethral reconstructioninclude urethrocutaneous fistulae and cosmetic appearance, which is usually measured by Hypospadias Objective Penile Evaluation (HOPE) scoring system.
AIM: The aim of this study was to determine whether there are differences in the outcome of flap method compare to TIP method in distal hypospadias patients who underwent urethroplasty.
PATIENTS AND METHOD: The subjects of this study were patients with distal hypospadias who underwent urethroplasty in Sanglah General Hospital from September 2017 to December 2017. Thirty-six samples were selected by consecutive sampling.
RESULTS: The results showed a significant difference in the incidence of meatal stenosis (p = 0.05) and urinary stream disturbances(p = 0.05) between two methods. No significant differences were found in the incidence of urethrocutaneous fistulae (p = 0.500) and the unsatisfactory HOPE score (p = 0.169).
CONCLUSION: This research showed that meatal stenosis andthe maximum urinary stream were better in flap method compared to TIP method in distal hypospadias patients underwent urethroplasty.
Cerebral Aspergilloma in Patient with Diabetes – A Case Report with Short Literature Review
Authors: Ivanova Koni , Valkanov Stefan , Petrov Bozhidar , Mindov Ivan , Gulubova Maya
Published: October 2020

BACKGROUND: In the recent years, the incidence of fungal brain abscess has been rising as a result of the increased use of corticosteroid therapy, broad-spectrum antimicrobial therapy, and immunosuppressive agents. Aspergillosis of the central nervous system (CNS) is reported in 10%–20% of the patients having invasive fungal disease. Commonly, the disease is observed in immunocompromised or immunosuppressed patients; also, patients who suffered traumatic head injury are reported as well to develop the infection due to due cranial defect accompanied by dural tearing. Symptoms are non-specific neurologic manifestations.
CASE PRESENTATION: We presented a case of a 68-year-old man who had diabetes mellitus type II. He was admitted to in neurosurgery clinic due reported head trauma. Initially, he complained of a headache, dizziness, slurred speech, nausea, and pain in the right ear with tinnitus and pain in his right upper teeth – continuous for a month. The patient was conscious, adequate, Glasgow Coma Scale – 15 points, with left-sided hemiparesis, general symptomatic syndrome. An emergent computed tomography scan was performed, which showed tumorous formation in patient’s right temporal lobe that had mass effect and compression of the right lateral ventricle. The patient was discussed on a emergent clinical counsel and it was decided that he was shown for surgical treatment. An informed consent was signed by the patient and his relatives. After the surgery intervention – the histological result of the biopsy was aspergilloma of the brain and the microbiological result was Aspergillus fumigatus.
CONCLUSION: The prognosis for CNS aspergillosis is poor, but the early diagnosis and effective medical and surgical treatments may reduce morbidity and mortality.
The Effect of Glutamine Supplementation to Fecal Calprotectin and Tumor Necrosis Factor-α Levels in the Fecal of Rats with Acute-Induced Diarrhea
Authors: Putra Deddy Satriya , Oenzil Fadil , Darwin Eryati , Bachtiar Hafni
Published: October 2020

BACKGROUND: Glutamine is a non-essential amino acid as the main fuel in the gastrointestinal mucosa. By its various gastrointestinal functions, glutamine is thought to increase the protection of the intestinal mucosa against local or systemic injury from diarrhea.
AIM: This study aimed to determine the relationship between glutamine supplementation and fecal calprotectin and tumor necrosis factor-α (TNF-α) in the fecal of rats with acute and chronic diarrhea induced by EPEC.
MATERIALS AND METHODS: The research was conducted in an experimental laboratory with a randomized post-test only control group design. A total of 30 Rattus norvegicus strain Wistar were divided into five groups. The treatment group was induced to have diarrhea using EPEC at a dose of 108 CFU/ml, after each group diagnosed by acute and chronic diarrhea, followed by glutamine supplementation at a dose of 810 mg/200 g for 14 days. The inflammatory cytoknies which is fecal calprotectin and TNF-α, of each group was assessed and the p value was measured by one-way ANOVA and post hoc Bonferroni test to find out the relationship between these variables.
RESULT: Supplementation of glutamine for 14 days can reduce fecal calprotectin levels in chronic diarrhea and reduce TNF-α level in rats with acute and chronic diarrhea.
CONCLUSION: Glutamine supplementation has an effect on the fecal calprotectin and TNF-α of rats with acute and chronic diarrhea.
Growth, Development, and Quality of Life in Children with Congenital Heart Disease Children
Authors: Maya Sri , Gunawijaya Eka , Yantie N. P. Veny Kartika , Windiani I. G. A. Trisna
Published: October 2020

BACKGROUND: Despite the advances in medical and surgical care have improved the survival rates of children with congenital heart disease (CHD), they still remain risky for nutritional, cognitive problems, and quality of life. Those impacts vary according to the severity of heart lesions and still manifested years after surgery.
AIM: The objective of this study was to compare growth, development, and quality of life between cyanotic and acyanotic CHD in 52 patients aged 24–69 months old from June to January 2018 in Sanglah Pediatric Cardiology clinic used WHO Anthro software, The Mullen Scales of Early Learning and PedsQL Cardiac module.
RESULTS: We found significant different proportion of underweight 11.5% in acyanotic children, 42.3% in cyanotic by weight/age z-score <−2SD (p = 0.033). Height/ age z-score <−3SD 38.5% in cyanotic versus 11.5% in acyanotic (p = 0.025). The cyanotic showed a significant difference in cognitive function, presented by early learning composite score (p = 0.044) particularly in gross motor (p = 0.034) and receptive language (0.047). Quality of life differs significantly between both groups in heart problem and therapy (p = 0.042), treatment anxiety (p = 0.016), cognitive problems (p = 0.038), and communication (p = 0.022).
CONCLUSION: Development, growth problems, and lower quality of life are common in cyanotic children, thus highlight the need for longitudinal surveillance.
Risk Factors and Prevalence of Soil-transmitted Helminth Infections
Authors: Brahmantya Ida Bagus Yorky , Iqra Haikal Hamas Putra , Hartawan I Gusti Ngurah Bagus Rai Mulya , Anjani Ida Ayu Widya , Sudarmaja I Made , Ryalino Christopher
Published: October 2020

BACKGROUND: Soil-transmitted helminths (STHs) infection is an infectious disease that has a high prevalence with unclear clinical symptoms and predominantly affects children in the age range of 5–14 years.
AIM: This study aims to determine the prevalence and risk factors for STH infections in elementary school students in an STH endemic area.
METHODS: This study was an observational analytic study with a cross-sectional design with a total sampling method. Risk factors were obtained by a questionnaire, and the diagnosis of STH infection was established through a fecal examination with the modified Kato-Katz method. The data are then processed and analyzed using the SPSS application. Chi-square test and risk assessment are used to determine risk factors for STH infection.
RESULTS: A total of 138 children participated in this study. The prevalence of STH infections obtained was 56.5% with Trichuris trichiura (53.8%), Ascaris lumbricoides (18%), and both (28.2%) as etiology. The degree of STH infection varies from mild-to-severe. All risk factors related to hygiene and sanitation have a statistically significant relationship with the prevalence of STH infections. Eating while playing on the ground was the most influential risk factor for the high prevalence of STH infections (p <0.001, PR = 2.611, CI 95% = 1.961–3.477).
CONCLUSION: The prevalence of STH infections in elementary schoolchildren in Tenganan village was 56.5%. Low personal hygiene and sanitation are risk factors for STH infection that can be overcome; therefore, it is necessary to introduce early prevention efforts in elementary schoolchildren as one risk group for STH infection.
The Influence of −174 G/C Interleukin 6 Promoter Gene Polymorphism to Interleukin 6 Concentration in the End Stage Renal Disease Patients with Dialysis: A Single-center Experience in Indonesia
Authors: Muzasti Riri Andri , Hariman Herman , Daulay Elvita Rahmi
Published: October 2020

BACKGROUND: Chronic kidney disease (CKD) is classified as a multifactorial disease as a combination of genetic and environmental factors that affect the onset and progression of end-stage renal disease (ESRD). In the last decades are recognized that inflammation, where the critical modulator is cytokines, can occur before the onset of kidney disease and can be a causative factor in the development of CKD. Interleukin (IL)-6 has several polymorphisms in the promoter region, such as 174 G-C, 634 C-G, 572 G-C, and 597 G-A. G/C single nucleotide polymorphism of the IL-6 gene at position 174 in the promoter region is reported to affect the level of IL-6 expression. Unfortunately, there is a lack of data about the genotype frequencies of -174 G/C IL-6 promoter gene polymorphism in Indonesian with ESRD.
AIM: This study aimed to analyze whether −174 G/C IL-6 promoter gene polymorphism influences the concentration of IL-6 in ESRD patients with dialysis in Indonesia.
METHODS: We recruited 95 outpatients who were undergoing regular hemodialysis for ≥3 months at the Rasyida Renal Hospital, Medan, in this cross-sectional study. IL-6 genotype polymorphism was analyzed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The enzyme-linked immunosorbent assay method was performed to assess the quantitative IL-6 serum.
RESULTS: PCR-RFLP examination showed the frequency distribution of the IL-6 genotype -174 G/C gene; 72 (75.8%) respondents had GG genotypes; 22.1% of respondents had the CG genotype, and (2.1%) had the CC genotypes. Patients with the CC genotype were statistically significant to have higher IL-6 concentration compared to other genotypes (p < 0.001). Likewise, with diabetic patients, statistics showed higher IL-6 concentration compared to non-diabetics patients (p < 0.001).
CONCLUSION: This is the first study showing that -174 G/C IL-6 promoter gene polymorphism influences the IL-6 concentrations in ESRD patients with dialysis in Indonesia. Multicenter studies are needed to validate these findings.
Oral Hard Tissue Lesions: A Radiographic Diagnostic Decision Tree
Authors: Mortazavi Hamed , Safi Yaser , Rahmani Somayeh , Rezaeifar Kosar
Published: October 2020

BACKGROUND: Focusing on history taking and an analytical approach to patient’s radiographs, help to narrow the differential diagnoses.
AIM: This narrative review article aimed to introduce an updated radiographical diagnostic decision tree for oral hard tissue lesions according to their radiographic features.
METHODS: General search engines and specialized databases including PubMed, PubMed Central, Scopus, Embase, EBSCO, ScienceDirect, and authenticated textbooks were used to find relevant topics by means of MeSH keywords such as “jaw diseases,” “maxilla,” “mandible,” “radiolucent,” “radiopaque,” “odontogenic,” “nonodontogenic,” “cysts,” and “tumors.” Related English-language articles published from 1973 to 2020, including reviews, meta-analyses, and original papers (randomized or non-randomized clinical trials; prospective; or retrospective cohort studies), case reports, and case series about oral hard tissue lesions were appraised.
RESULTS: In this regard, bony lesions have been classified according to their radiographic pattern (radiolucent, mixed, radiopaque, and rarified), position (periapical, pericoronal and interradicular), margins (well and ill-defined), relation to dentition (with and without dental association), and number (solitary and multiple). In total, 50 entities were organized in the form of a decision tree.
CONCLUSION: In this paper, an updated decision tree was proposed to help dental practitioners to make more accurate diagnoses and better treatment plans on the basis of radiographic characteristics.
The Effect of Follicular-fluid Exposure of Endometriosis Cyst Patients toward the Levels of Bcl-2 and Cytochrome-C in Mice Oocyte
Authors: Adnyana Ida Bagus Putra , Jawi I Made , Suwiyoga Ketut , Bakta I Made , Astawa I Nyoman Mantik , Anwar Mochammad , Manuaba Ida Bagus Putra , Sutirtayasa I Wayan Putu , Satriyasa Bagus Komang
Published: October 2020

BACKGROUND: Endometriosis cysts adversely affect a woman’s quality of life, which causes pain and reduces fertility. The World Health Organization found that the incidence of endometriosis with infertility clinical manifestations is around 10%.
AIM: The purpose of this study is to determine the presence of mice oocytes mitochondrial apoptosis exposed with endometriosis cysts follicular fluid through Bcl-2 and cytochrome C analysis.
METHODS: This study was a randomized post-test only control group design conducted at Sanglah Hospital, Bali Royal Hospital in Denpasar, and the Medical Faculty Udayana University from June 2018 to April 2019. A total of 120 mice oocytes were distributed randomly into three groups, i.e., treatment Groups 1 and 2 that added by 15% endometriosis cysts follicular fluid and control group. Bcl-2 and Cytochrome C analyzed with ELISA Technique. Comparability was tested with one-way ANOVA with a significance level of p < 0.05.
RESULTS: Eighteen mice oocyte replicates were normally distributed and homogeneous. The Bcl-2 levels in the treatment Groups 1, and 2 and control were 627.83 ± 146.42, 634.50 ± 140.62, and 678.83 ± 152.71, respectively; p = 0.838 (not significantly different). Cytochrome C levels in the treatment Groups 1, and 2, and control, respectively, were 3147.75 ± 228.50, 3104.45 ± 211.29, and 2738.28 ± 227.45; p = 0.021 (significantly different).
CONCLUSION: The effect of endometriosis cysts follicular fluid exposure on mitochondrial apoptosis is proven through Cytochrome C, whereas Bcl-2 is not proven.
Clinical and Demographic Characteristics of Patients with COVID-19 Who Died in Modarres Hospital
Authors: Valizadeh Rohollah
Published: October 2020

BACKGROUND: Novel coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome-CoV2 as a century concern affecting public health.
AIM: This study aimed to find the clinical and demographic characteristics of the patients died following COVID-19 development at Modarres Hospital, Tehran, Iran.
METHODS: In this descriptive-analytical cross-sectional study, 62 patients died following COVID-19 were studied in terms of age, gender, body mass index, comorbidity, symptoms, liver profile, lipid profile, hemoglobin, platelet, white blood cell, lymphocytes, neutrophils, C-reaction protein, polymerase chain reaction (PCR), creatine phosphokinase, creatinine, blood urea nitrogen (BUN), potassium, magnesium, and sodium.
RESULTS: The results showed that 71% of patients were male and 69.4% had positive PCR test indicating low sensitivity of the test; 90.3% of patients were above 60 years old; 56.5 of patients had lymphocytopenia; the mean age was 67.62 ± 15.07 years; with symptoms lasting 6.24 days. The mean serum creatinine and BUN were 3.18 g/dl and 125.9 mg/dl, respectively, indicating renal involvement. All patients had pulmonary involvement accompanied by other organ involvements. Regarding symptoms, 72% of patients showed fever. Some affected patients had diarrhea, lethargy, and fatigue. A comparison of comorbidities by gender showed no significant differences.
CONCLUSION: According to our results, the majority of patients were overweight. In people who are more than 60 years, multi-organ failure was notable. Fever, cough, and shortness of breath were dominant symptoms like other studies, but neurological complications following COVID-19 as meningoencephalitis is possible that can be used as a differential diagnosis. We did not found differences between male and female regarding comorbidity, symptoms, and mortality rate.
Human Vaccines and Herpes Zoster Ophthalmicus: Clinical Manifestation, Treatment, and Prevention
Authors: Yuwanda Vina
Published: October 2020

Herpes zoster ophthalmicus (HZO) is a reactivation of HZ virus that is latent in ophthalmic division of trigeminal ganglion. Patients over 50 years old, premature infant, pregnancy woman, receiving immunosuppressive agents, and malignancies are at risk of having HZO. Ocular manifestations of HZ are ectropion, entropion, ectopic eyelash, keratitis, conjunctivitis, symblepharon, hypoesthesia, episcleritis, scleritis, scleral atrophy and thinning, uveitis, iris atrophy, posterior synechiae, acute retinal necrosis, progressive outer retinal necrosis, retinal detachment, retina atrophy, optic neuritis, optic atrophy, and strabismus. Polymerase chain reaction, antigen detection, and antibody detection can help to confirm diagnosis. Pharmacology treatments for HZ ophthalmicus are antiviral drugs, corticosteroids, analgesics, tricyclic antidepressants, and antiepileptic drug. Non-pharmacology therapies are scleral contact lens, phototherapeutic keratectomy, photorefractive keratectomy, and penetrating keratoplasty. There are two kinds of vaccination which can be given to patients: Live-attenuated varicella zoster vaccine and recombinant zoster vaccine. It is recommended by Centers for Disease Control and Prevention and Food and Drugs Administration to use recombinant zoster vaccine by 50 years old.
Enfrentamento à violência doméstica em tempos de pandemia: as ações do Núcleo Maria da Penha-NUMAPE/Irati
Authors: Santos Katia Alexsandra dos , Zarpellon Bianca Carolline Oconoski , Soares Izabel Cristina , Sasse Jonathan
Published: October 2020

Nesta nota técnica, apresentamos algumas ações desenvolvidas pela equipe do Projeto de Extensão Núcleo Maria da Penha-NUMAPE (UNICENTRO/Irati) no que diz respeito ao enfrentamento da violência doméstica. A partir de relato de experiência de ações desenvolvidas por equipe interdisciplinar composta pelas áreas do Direito e Psicologia, narramos os deslocamentos produzidos pela pandemia do COVID-19 que colocaram alguns desafios para a equipe do projeto: necessidade de realização de atendimentos remotos, foco na prevenção e auxílio para situações de caráter emergencial, tais como encaminhamento para rede de proteção e para recebimento do auxílio emergencial disponibilizado pelo governo federal. Entre os resultados , destacamos a contradição entre o possível aumento da violência doméstica em situação de distanciamento social e, por outro lado, a dificuldade de ações de enfrentamento, tais como denúncias e processo de desvinculação dos agressores.
Cultura na UTFPR em tempos de pandemia: construção de site colaborativo de apoio ao isolamento social
Authors: Prueter Priscilla Battini , Porto Alegre Laize Márcia
Published: October 2020

O artigo em questão aborda o desenvolvimento de um site colaborativo desenvolvido pelas Comissões de Cultura, instituídas nos 13 Câmpus da UTFPR, vinculada à Assessoria de Cultura da Diretoria de Extensão na Pró-Reitoria de Relações Empresariais e Comunitárias da UTFPR. O site foi elaborado, editado e publicado contando com a colaboração de vários editores e/ou internautas para amenizar o impacto do isolamento social e de angústias provocadas pela pandemia da Covid-19, devido ao contrato com o Google for Education e UTFPR, possibilitando o acesso a várias ferramentas e contas institucionais para servidores. A ferramenta escolhida para a elaboração do site colaborativo foi o Google Sites. Os integrantes das Comissões de Cultura chegaram a resultados bastante relevantes e de valia para uso na prática diária nestes tempos de pandemia pelo coronavírus. As atividades culturais disponibilizadas no site evidenciam o favorecimento do conhecimento produzido na instituição e também outras contribuições para servir a sociedade não apenas para estudantes e servidores como também para a comunidade em geral.
Luteria digital experimental: singularização de instrumentos digitais em contexto pós-industrial
Authors: De Deus Raydson Alexandre Tozzo , Nespoli Eduardo
Published: October 2020

O artigo analisa a aproximação entre arte e tecnologia por meio do estudo dos processos criativos relacionados à luteria digital experimental. Para tanto, observa-se que o trabalho criativo realizado pelo luthier de instrumentos experimentais possui caráter manual, remetendo o processo de construção a um tipo de prática artesanal que, porém, utiliza componentes industrializados como material preliminar. Neste contexto de criação, o luthier explora procedimentos de permutação de componentes eletrônicos padronizados,  buscando alcançar resultados estéticos singulares. Partindo desse jogo de combinações, o construtor de instrumentos experimentais integra arte e tecnologia em uma instância guiada pela valoração estética do objeto, adquirindo, deste modo, o ponto de abertura que lhe permite verificar o objeto tecnológico enquanto algo assimétrico, singular  e ajustável aos sentidos que se deseja produzir.
O direito à privacidade no tempo do big data: narrativas profissionais na União Europeia
Authors: Neiva Laura
Published: October 2020

Assiste-se hoje a um crescente debate em torno dos direitos humanos e dos grandes dados. Este artigo explora as expectativas de profissionais envolvidos na partilha transnacional de dados genéticos, geneticistas forenses e stakeholders de diferentes áreas relativamente à inclusão de Big Data na investigação criminal transnacional. Tendo por base uma metodologia qualitativa de análise de conteúdo de entrevistas, o objetivo é delinear os sentidos e aceder às significações que estes profissionais atribuem ao Big Data enquanto potencial técnica de investigação criminal, no âmbito das suas atividades profissionais. Apesar da promessa do potencial dos grandes dados em termos de eficácia e eficiência, a sua inclusão nos meios de investigação criminal impõe questões éticas e de direitos humanos que importam estudar. Concluo que os entrevistados referem a dificuldade de encontrar o equilíbrio entre a garantia dos direitos, liberdades e garantias dos indivíduos com a promoção da segurança pública; a ética da investigação criminal; e as violações ao direito à privacidade.
Impacto da indústria 4.0 na geração de inovação em tecnologias médicas: uma abordagem patentária
Authors: Goes Ana Beatriz Bassette , Munhoz Igor Polezi , Akkari Alessandra Cristina Santos
Published: October 2020

Fatos globais que desafiam a saúde pública, como a pandemia de COVID-19 e o envelhecimento populacional, requerem uma visão holística da aplicação das tecnologias 4.0 com novas práticas sociais. O objetivo desse artigo foi mapear o potencial da Indústria 4.0 na geração de inovação médica. Para tanto, desenvolveu-se um estudo exploratório e descritivo, de natureza aplicada e com uma abordagem quantitativa baseada na coleta e tratamento estatísticos de dados patentários para Brasil, EUA, Alemanha e Suíça. Constatou-se a baixa contribuição mundial do Brasil (0,08%) na geração de tecnologias, enquanto que EUA e Alemanha destacaram-se em capacidade inovativa. Todos os países mostraram uma variação relativa positiva (> 17%), entre 2011–2017. Conclui-se sobre a influência da Indústria 4.0 na inovação médica, apontando a aplicação de tecnologias 4.0 como estratégia de desenvolvimento social. Logo, esse artigo contribui para direcionar políticas de ciência, tecnologia e inovação a fim de otimizar índices de assistência à saúde.
Reflexões sobre mobilizações sociais em rede na contemporaneidade: novos exercícios de agência e cidadania
Authors: Santos Gustavo Souza
Published: October 2020

Manifestações diversas ocuparam espaços e vocalizaram demandas de natureza social, econômica e política pelo mundo, desde 2010. Mobilizações como a Primavera Árabe, o Occupy Wall Street, a Revolução dos Pinguins, a Geração à rasca, as mobilizações de 15-M e da Praça Syntagma até as Jornadas de Junho tornaram as ruas vórtices para reivindicações e exercícios de ação e participação política. A insurgência destas manifestações foi marcada pelo usufruto de redes sociais como instrumentos de aporte à organização, articulação e difusão dos atos. A proposta do texto é refletir a emergência de mobilizações sociais em rede contemporâneas e a produção de novos exercícios de cidadania, democracia e fazer político diante do ciberespaço. Destaca-se a interlocução entre insurgências on-line e off-line e a comunicação em rede como indumentária popular para a ação política.
Aprendizagem baseada em projeto no desenvolvimento de competências na educação a distância: uma análise a partir da gestão do conhecimento
Authors: Salerno Byanca Neumann , De Aguiar Rafaela Wille , Freitas Maria do Carmo Duarte
Published: October 2020

O uso de metodologias ativas tem sido estimulado na Educação a Distância por colocar o estudante no centro do processo de aprendizagem e por desenvolver determinadas competências requeridas pelo mercado de trabalho. Nesse contexto, a Gestão do Conhecimento facilita a melhoria do processo de aprendizagem por meio do mapeamento do desenvolvimento de competências. Esta pesquisa objetiva verificar se as estratégias e metodologia ativa baseada em projetos em uma disciplina totalmente a distância da Universidade Federal do Paraná promoveram o desenvolvimento das competências previstas em sua ementa. Para isso, utilizou-se o estudo de caso apoiado por pesquisa bibliográfica e documental, observação participante não estruturada e aplicação de questionário semiaberto com os estudantes. Os resultados mostram que as estratégias e a metodologia ativa baseada em projetos contribuíram para o desenvolvimento das competências previstas, ainda que seu estágio tenha variado. Conclui que a Gestão do Conhecimento favorece a melhoria do processo de aprendizagem por permitir mapear os erros e acertos do processo.
Gestão da informação em bibliotecas universitárias: uma perspectiva dos usuários da biblioteca da escola de engenharia da Universidade Federal do Rio Grande do Sul
Authors: Paranhos de Oliveira Mariana
Published: October 2020

O estudo avaliou a qualidade da Gestão da informação da Biblioteca da Escola de Engenharia (BIBENG) da Universidade Federal do Rio Grande do Sul. Isso, utilizando a percepção do usuário final, com o objetivo de analisar a qualidade e o nível das atividades desenvolvidas na gestão informacional. A metodologia é qualitativa descritiva. O instrumento de coleta de dados utilizado foi um questionário aplicado aos usuários da biblioteca. As discussões embasaram-se em conceitos relativos à ciência da informação, teoria administrativa e bibliotecas universitárias. Com os resultados obtidos, afirma-se que a GI da BIBENG apresenta quadro geral positivo, sendo o acervo completo e em excelentes condições. As fontes de informação mais utilizadas são livros, periódicos e trabalhos acadêmicos. Os instrumentos de divulgação possuem pertinência mediana. O atendimento prestado e a organização foram avaliados positivamente. Melhorias foram sugeridas. Assim, a GI na BIBENG está cumprindo o seu papel.
L’entreprise sous le prisme des combinaisons des méthodes d’agilité, de créativité et de veille
Authors: Goria Stéphane
Published: October 2020

L’adjectif « agile » est désormais employé pour qualifier un idéal d’entreprises dynamiques et innovantes. De fait, deux interprétations de ce terme peuvent être envisagées. La première renvoie à la mise en place systématique d’une gestion de projet en mode agile, c’est-à-dire se conformant à certaines valeurs et principes formulés dans un manifeste. Celui-ci met notamment l’accent sur le développement en cycles courts, le travail en petite équipe, une conception en collaboration avec les clients et l’acceptation bienveillante des changements de besoins. La seconde se rapporte à une entreprise capable de répondre plus vite et mieux que ses concurrentes à des changements environnementaux. Dans ces deux cas, la créativité et la veille jouent un rôle important. Elles permettent à l’entreprise de rester agile en : identifiant les changements environnementaux, alertant sur ses propres routines, envisageant rapidement des réponses pertinentes pour ses clients et, autant que possible, surprenantes pour ses concurrents. JEL Codes  : D83, L15, 031, 032
Le management des connaissances inventives : du patrimoine intellectuel inventif à l’innovation
Authors: Saulais Pierre , Ermine Jean-Louis
Published: October 2020

L’objet du présent article est de montrer que le management des connaissances est centré sur un objet de connaissances que constitue le patrimoine de connaissances et que le principe fécond de celui-là est de préserver, enrichir, valoriser, partager et transmettre celui-ci. Ce principe est adossé à des concepts de modélisation formelle des connaissances appliqués aux connaissances considérées comme critiques et stratégiques, concepts adossés au cycle vertueux des connaissances. Ces concepts sont appliqués au travers d’une méthode opérationnelle, MASK. Le passage des connaissances en général aux connaissances inventives amène au management des connaissances inventives centré sur le patrimoine intellectuel inventif, qui se trouve lui-même au cœur de la partie en amont du processus d’innovation. JEL Codes  : D83
Existence of a unique solution to an elliptic partial differential equation when the average value is known
Authors: Denny Diane
Published: October 2020

The purpose of this paper is to prove the existence of a unique classical solution $u(\bf{x})$ to the quasilinear elliptic partial differential equation $\nabla \cdot(a(u) \nabla u) = f$ for $\bf{x} \in \Omega$, which satisfies the condition that the average value $\frac{1}{|\Omega|}\int_{\Omega} u d\bf{x} = u_0$, where $u_0$ is a given constant and $\frac{1}{|\Omega|}\int_{\Omega} f d\bf{x} = 0$. Periodic boundary conditions will be used. That is, we choose for our spatial domain the N-dimensional torus $\mathbb{T}^N$, where $N = 2$ or $N = 3$. The key to the proof lies in obtaining a priori estimates for $u$.
La Escuela Normal y la educación de las élites científicas en el siglo XIX, en Francia, con un estudio sobre los Anales Científicos de la E.N.S
Authors: Malet Antoni
Published: October 2020

Por lo que se refiere a la formación de científicos, en algún momento del siglo XIX la Ecole Normale Supérieur asumió el papel dirigente y solitario desempeñado por la Ecole Polythechnique durante el primer tercio del siglo. Este artículo estudia tres cuestiones relacionadas con este cambio institucional. En primer lugar, proporciona evidencia cuantitativa según la cual las décadas entre 1830-40 y 1870-80 presenciaron los cambios más importantes por lo que se refiere al número de científicos formados en cada una de estas escuelas. En segundo lugar, el artículo sostiene que el carácter elitista y las dimensiones reducidas de la Ecole Normale permitieron implementar en esta institución planes de reforma que ya en los años 1830 habían sido formulados para toda la universidad francesa. Finalmente, el artículo estudia los Annales Scientifiques de l'Ecole Normale Supérieur, la revista fundada para subrayar la conversión de la escuela en un centro de formación de científicos. Este estudio proporciona datos importantes sobre dos cambios mayores que afectaron a las revistas científicas en esta época: su especialización por disciplinas y su jerarquización según el valor científico de sus artículos.