bluuebunny/crossref_metadata_2025 huggingface dataset:
STRATEGI MANAJEMEN RISIKO LINKAGE PROGRAM POLA EXECUTING AKAD MUDHÄ€RÄ€BAH PADA PT. BANK MUAMALAT INDONESIA KANTOR CABANG DARMO
Authors: Barik Rizqi Yuniar
Published: July 2023

Linkage program pola executing merupakan sebuah model pembiayan yang diberikan Bank Umum Syariah (BUS) kepada Lembaga Keuangan Mikro Syariah (LKMS). Skema pembiayaan linkage program pola executing ini dijalankan dengan menggunankan prinsip akad mudhÄrÄbah. Dengan adanya linkage program ini keberadaan BUS dan LKMS akan bersinergi dan menimbulkan mutual benefit bagi keduanya.
Penelitian ini menguraikan tentang bagaimana implementasi pembiayaan linkage program pola executing akad mudharabah di Bank Muamalat Indonesia Kantor Cabang Darmo, serta bagaimana strategi manajemen risiko untuk memitigasi risiko yang muncul dari pembiayaan tersebut.
Data penelitian diperoleh dari data internal Bank Muamalat Indonesia Kantor Cabang Darmo berupa file, laporan tahunan dan wawancara secara langsung dengan pihak yang menangani linkake program pola executing, khususnya dari unit risiko Bank Muamalat Indonesia, serta literatur pendukung yang relevan dengan permasalahan yang diangkat dalam penelitian ini. Selanjutnya dianalisis menggunakan metode deskriptif analisis.
Berdasarkan hasil penelitian, bahwa implementasi linkage program pola executing pada Bank Muamalat Indonesia Kantor Cabang Darmo telah dijalankan sesuai dengan regulasi yang telah ada yakni Generic Model Linkage Program yang dirumuskan oleh Arsitektur Perbankan Indonesia (API). Terkait strategi manajemen risiko linkage program pola executing Bank Muamalat menerapkan strategi dengan tetap berkontribusi dalam pengelolaan risiko dari end user. Strategi itu dilaksanakan pada awal proses pembiayaan. Setelah pembiayaan berjalan penekanan monitoring dilakukan pada pihak LKMS karena terhalang oleh karakter executing dan akad mudhÄrÄbah.
ANALISIS KESEHATAN BANK SYARIAH DENGAN MENGGUNAKAN METODE RGEC (RISK PROFILE, GOVERNANCE, EARNINGS AND CAPITAL) DALAM MENJAGA STABILITAS KESEHATAN PADA PT. BANK BNI SYARIAH TAHUN 2016
Authors: Sa’diah Rohmatus , Buchori Imam
Published: July 2023

Penelitian ini bertujuan untuk mengetahui bagaimana penerapan metode RGEC (risk profile, governance, earnings dan capital) dalam menganalisis kesehatan Bank BNI Syariah Tahun 2015 dan bagaimana analisis tingkat kesehatan dengan menggunakan metode RGEC (risk profile, governance, earnings dan capital) dalam menjaga stabilitas kesehatan Bank BNI Syariah  tahun 2016. Metodologi penelitian yang digunakan adalah pendekatan kualitatif dengan jenis penelitian deskriptif. Hasil penelitian yang diperoleh adalah Berdasarkan penilaian tingkat kesehatan PT. Bank BNI Syariah tahun 2015 dengan menggunakan metode RGEC yang meliputi aspek risk profile, governance, earnings dan capital,  didapatkan hasil bahwa kesehatan PT. Bank BNI syariah berada pada peringkat 2 yaitu SEHAT dengan nilai keseluruhan 83,33%. Dalam hal ini PT. Bank BNI syariah mampu menghadapi pengaruh negatif yang signifikan dari perubahan kondisi bisnis dan faktor eksternal lainnya. Dan juga PT. Bank BNI syariah mampu menjaga stabilitas kesehatan bank syariah di tahun 2016. Hal ini dibuktikan dengan penilaian kesehatan PT. Bank BNI syariah di triwulan pertama dan kedua tahun 2016 dengan peringkat SANGAT SEHAT.Dari hasil dari penilaian kesehatan dengan menggunakan metode RGEC ini juga dapat dijadikan acuan untuk  evaluasi, saran perbaikan dan menjaga stabilitas kesehatan bank syariah.
PENGGUNAAN KOIN SHOPPEE DALAM JUAL BELI SALAM DI SHOPPEE
Authors: Egi Lestari Irsa , Fitriyah Mahdiyah , Fitri Rahmawati Riska
Published: July 2023

Perkembangan zaman yang sangat pesat pada masa ini menyebabkan masyarakat lebih banyak melakukan transaksi jual beli secara online. salah satu marketplace yang banyak diminati adalah shopee.co.id dimana Shopee mampu menyediakan bebagai fitur menarik dengan manajemen pemasaran yang baik. Salah satu fitur unngulan Shopee adalah koin Shopee, koin tersebut merupakan koin emas yang dapat digunakan sebagai chash back oleh setiap pengguna ketika melakukan transaksi jual beli serta didukung dengan cara mendapatkannya yang relatif mudah. Aplikasi Shopee sendiri dalam hukum Islam disebut dengan istilah simsaroh (makelar). Simsaroh yaitu jualbeli di mana ada satu pihak yang menjualkan barang milik orang dan mendapatkan upah atas jasanya menjualkan barang tersebut. Oleh karena itu pada penulisan ini penulis mendreskripsikan tentang hukum penggunaan koin Shopee pada jual beli salam di shopee.co.id. Penulisan ini menggunakan metode kualitatif yang berlandaskan pada teori-teori serta data-data yang didapatkan diambil dari literasi. Maka berdasarkan analisis yang dilakukan diperoleh kesimpulan bahwa penggunaan koin shopee adalah halal, koin shopee dapat dimanfaatkan sebagai diskon atau potongan harga sehingga koin shopee dapat mempermudah pengguna dalam melakukan transaksi. Koin Shoppe juga memiliki daya pikat bagi konsumen untuk melakukan Online Shopping menggunakan aplikasi shoppee. Jadi, koin shopee merupakan strategi pemasaran shoope yang dapat memberikan dampak baik kepada semua pihak.
Food Prices Policy: Relational Implementation of Fiqh Muamalah and Islamic Economics
Authors: Fuad Zakiyyul
Published: July 2023

There are fundamental differences between Islamic economics and Fiqh Mu‘āmalah, as well as the relationship between the two, according to Anas Zarqa and Monzer Khaf. However, according to Qadri Azizi, Islamic economics and Fiqh Mu‘āmalah are not different because there is no difference in terms of material objects. This study aims to understand the food price policy by the government as a relational implementation of Fiqh Mu‘āmalah and Islamic economics by analyzing the epistemology of Islamic economics between economics and Fiqh Mu‘āmalah, and also to understand the relation between Fiqh Mu‘āmalah and Islamic economics in food price policy by the government as a strategic study of the economy. This study is qualitative descriptive, using a content analysis tool and literature study. The results of this study are 1) There are fundamental differences between economics and Fiqh Mu‘āmalah in the epistemological aspect, which creates a scientific discipline that combines the two into Islamic Economics. 2) Fiqh Mu‘āmalah as a normative study sourced from the Alquran and hadith functions as a basis in economic cases through observation and description of phenomena. Therefore, without a touch of values and sharia norms, economics remains value-free. In terms of food price policy, factors such as economic conditions, consumer behavior, and policy implications will be a reference in normative-strategic studies for Islamic economists to sort out and determine rules that are more relevant and have greater maṣlaḥah.
The role of perinatal protection of a fetus in preservation of the health of the nation
Authors: Zavyalov Oleg V. , Ignatko Irina V. , Strizhakov Aleksander N. , Pasechnik Igor N. , Kardanova Madina A.
Published: July 2023

This review examines the international role of perinatal protection of a fetus in preservation of the health of the nation. Historical perspectives, present-day developments, and future priorities of perinatal medical science are given. The etiology of decompensated placental insufficiency and intrauterine growth restriction is considered. The authors also considered the epidemiology of premature delivery and perinatal outcomes, the problem of development, diagnosis and obstetric management in critical fetal condition is covered in detail. The current review of literature was conducted in order to advance the theoretical knowledge of specialists on modern complex issues of perinatal medicine. The considered practical aspects will contribute to the improvement of interdisciplinary interaction between clinicians of various specialties in the field of perinatal protection of a fetus and, through this, to the preservation of the health of the nation and the multiplication of future generations.
Parameterization of a ventilation network model for the analysis of mine working emergency ventilation modes
Authors: Perestoronin M. O. , Parshakov O. S. , Popov M. D.
Published: July 2023

Digital simulation of mine fires and explosions is an important stage in the process of developing technical solutions and measures aimed at improving the safety of personnel involved in underground mining. Correct simulation results determine the effectiveness of decisions in the event of an actual emergency situation. In this regard, due attention should be paid to each stage of the simulation, and especially to the initial stage of model parameterization. This study formulates a general principle for determining the parameters of mine fire and explosion models, in order to assess their development using the AeroNetwork analytical package. Such parameters in the event of a fire are heat and gas (afterdamp) releases. In the event of an explosion, excessive pressure at the shock front in the explosion origin. It has been established that when simulating a fire, it is advisable to use equivalent heat and gas releases determined by the content of combustible components in the combustion origin. In the event of burning mining equipment, these parameters can be calculated on the basis of the technical characteristics of a machine. Furthermore, when simulating an unauthorized explosion of explosives, the excess pressure determined by the dimensionless length of the active combustion area is calculated taking into account the weight and specific heat of an explosive, as well as the geometric parameters of a mine working. When simulating an explosion of a methane-air mixture (firedamp), the excess pressure is calculated taking into account the gas content of rocks in terms of free combustible gases, the length of a blast cut, the size of the area of increased fracturing, and the lower explosive limit of methane. Based on the proposed principle of the parameterization of emergency models, as an example, a model of fire and explosion development in existing extended dead-end workings (more than 1000 m long) passing coaxially to each other at different heights was developed. The numerical simulation of different emergency situations in workings was carried out, taking into account performing mining in difficult mining conditions.
Development and substantiation of an improved version of a main drainage facility classical scheme at a kimberlite mine developed by block caving method
Authors: Ovchinnikov N. P.
Published: July 2023

Evidence demonstrates that as the production capacity of a kimberlite mine increases, there is a corresponding increase in the volumetric concentration of suspended solids in the mine water extracted from its watercollecting workings. The Udachny mine, known for its high productivity in comparison to other domestic kimberlite mines, experiences a higher concentration of suspended solids in the mine waters, leading to significant sludge settling within the primary drainage facility’s water-collecting workings. This determinal effect adversely affects the operational efficiency of pumping equipment and the reliability of LHDs. To address these issues, an enhanced version of the conventional main drainage facility scheme, specifically designed for kimberlite mine utilizing the block caving method, is proposed. This modified scheme aims to provide improved clarification of the mine water in the water-collecting workings and facilitate more efficient dewatering of the settled slurry sludges. Furthermore, a methodology has been developed to determine the time required for slurry sludge removal, the sedimentation characteristics of the solid phase, and the rheological properties of the liquid phase of the mine water.
The role of circulating tumor DNA in diagnosis and optimization of treatment of localized and local pancreatic cancer
Authors: Shabunin A. V. , Ptushkin V. V. , Tavobilov M. M. , Titov K. S. , Kobzev Ju. N. , Karpov A. A. , Kudryash E. B.
Published: July 2023

Pancreatic cancer (PC) is a malignant highly aggressive tumor that arises and grows under conditions of inflammation and tissue hypoxia. In PC, one of the key processes in progression is epithelial-mesenchymal transition, which leads to early dissemination and rapid realization of metastatic disease, which accounts for low overall survival rates. The tumor, by releasing a wide range of different molecules (circulating DNA, exosomes, proteins and lipids), allows to identify and use them as potential, diagnostic and prognostic biomarkers.

This review introduces readers to the liquid biopsy technique. The main applications of the technique in patients with ductal adenocarcinoma of the pancreas are shown. Liquid biopsy is a modern diagnostic method of molecular oncology, the principle of which is to detect circulating tumor cells, DNA, exosomes in biological fluids. Publications evaluating the potential of the method to assess minimal residual disease, evaluate tumor response to systemic therapy, and determine prognosis are discussed. Liquid biopsy is particularly relevant in cases of malignant tumors of difficult localization, in particular, PC. Modern methods of morphological verification of pancreatic tumors (fine needle biopsy under endosonographic control and percutaneous biopsy) have essential disadvantages: low information value, multiple repeated interventions, postmanipulative complications (pancreatitis, bleeding, etc.). Taking into consideration obvious advantages and perspectives of this method over traditional methods of morphological verification, liquid biopsy seems to be a promising diagnostic tool in personalized oncology for pancreatic cancer.
Gastric carcinoma and peritoneal mesothelioma – a rare case of synchronous cancer. Clinical observation
Authors: Abdullaev A. G. , Kozlov N. A. , Stilidi I. S.
Published: July 2023

Primary-multiple malignant neoplasms develop in about 9 % of cancer patients in the Russian Federation, while synchronous tumors are detected in a quarter of them, which dictates the need for a mandatory multidisciplinary approach to the choice of treatment. Localization of synchronous primary-multiple tumors in one anatomical zone requires a qualitative interpretation of instrumental diagnostic methods and morphological analysis after biopsy of each tumor. Along with this, there is a possibility of an erroneous opinion about the presence of different histological structures of the detected tumors and the data of visual assessment methods are interpreted in favor of a single disease.

This paper presents a clinical observation of a rare combination of gastric adenocarcinoma and peritoneal mesothelioma. The case was discussed at a multidisciplinary consultation with the participation of a surgeon, a chemotherapist and a radiologist. Taking into account the clinical stage of gastric body cancer c T3N1M0, III stage, it was decided to conduct preoperative polychemotherapy at the first stage. Repeated diagnostic laparoscopy revealed no negative dynamics, multiple small dropouts in the peritoneum persisted. Subsequently, the operation was performed in the volume of gastrectomy, total parietal peritectomy and appendectomy without macroscopic signs of a residual tumor. It was decided to refrain from intra-abdominal chemoperfusion with hyperthermia due to the large volume of surgery and the previous 8 courses of polychemotherapy. Microscopic examination of the altered part of the stomach wall revealed residual adenocarcinoma (type according to Lauren – intestinal) with signs of therapeutic pathomorphosis G3 (according to Mandard), which had grown into the subserous layer and the fiber of the small omentum, with signs of perineural invasion, in the absence of vascular invasion; resection edges – R0. On the surface of the removed fragments of the peritoneum, various foci of malignant epithelioid mesothelioma were found. At the control examination a year later, according to computed tomography and esophagogastroduodenoscopy, there were no signs of progression, the patient’s condition was satisfactory.
Expression of β2 microglobulin on malignant multiple myeloma plasma cells
Authors: Tupitsyn N. N. , Tolstykh E. E.
Published: July 2023

Background. β2‑microglobulin is a low molecular weight glycoprotein that is part of the major histocompatibility complex. The concentration of β2‑microglobulin in the blood serum of patients increases with various oncohematological pathologies, including multiple myeloma. One of the methods for detecting membrane β2‑microglobulin is flow cytometry. This article discusses the expression of β2‑microglobulin and key markers on the membrane of malignant cells in patients with multiple myeloma at the onset of the disease.

Aim. To study the expression of β2‑microglobulin and markers CD45, CD56 and CD19 on the membrane of tumor plasma cells in the primary diagnosis of multiple myeloma.

Materials and methods. The study of β2‑microglobulin and CD45, CD56 and CD19 was carried out in 37 patients with multiple myeloma by 8‑color flow cytometry using a panel of monoclonal antibodies for the diagnosis of plasma cell tumors (EuroFlow, 2012).

Results. The expression of β2‑microglobulin in combination with markers CD45, CD56 and CD19 on tumor plasma cells was assessed, illustrations of the expression of these markers are presented. Out of 37 patients with multiple myeloma, hyperexpression of β2‑microglobulin was noted in 23 (62.2 %), in other cases there were normal or reduced levels of this protein in other cases.

Conclusion. Tumor plasma cells overexpress β2‑microglobulin in a significant percentage of cases (62.2 %). This allows further assessment of the clinical significance of such aberrant expression and its relationship with serum levels of β2‑microglobulin.
Taxicab Correspondence Analysis and Taxicab Logratio Analysis: A Comparison on Contingency Tables and Compositional Data
Authors: Choulakian Vartan , Allard Jacques , Mahdi Smail
Published: July 2023

In this paper, we attempt to see further by relating theory with practice: First, we review the principles on which three interrelated well developed methods for the analysis and visualization of contingency tables and compositional data are erected: Correspondence analysis based on Benzécri’s principle of distributional equivalence, Goodman’s RC association model based on Yule’s principle of scale invariance, and compositional data analysis based on Aitchison’s principle of subcompositional coherence. Second, we introduce a novel index named intrinsic measure of the quality of the signs of the residuals for the choice of the method. The criterion is based on taxicab singular value decomposition, on which the package TaxicabCA in R is developed. We present a minimal R script thatcan be executed to obtain the numerical results and the maps in this paper. Third, we introduce a flexible method based on the novel index for the choice of the constant to be added to contingency tables with zero counts so that logratio methods can be applied.
Responsibility for Wrongdoing and Touching It: the Temporal Evolution of the Norms of Domestic Criminal Law
Authors: Semykina Olga I.
Published: July 2023

In different periods of the development of the Russian state, the interest of legislators, theorists and practitioners in improving the measures of criminal legal influence on persons involved in crime in general and acts of injustice in particular was not the same. To a large extent, the criminalization of such acts was conditioned by the requirements of vital necessity in combating crimes that affect the priority interests of the State, including the legitimacy of State power, economic security and property rights.
The purpose of the study is to determine the historical roots of the formation and evolution of the development of those forms of wrongdoing and touching them that have become the foundation of modern institutions of criminal law: obstruction of justice, harboring of crimes, failure to report a crime, connivance to crimes, criminal liability of legal entities and exemption from liability.
The key means and ways to achieve the goal were temporal and comparative legal methods of studying the institutions of criminal responsibility for wrongdoing and touching it in legal sources of the XVXX centuries. Such an approach to the study made it possible in an evolutionary context to present the most clearly the conclusions of the transformation of the architectonics of various institutions of domestic criminal law familiar to our time.
Their diachronic development follows from the temporal analysis of acts related to acts of injustice (harboring of crimes, failure to report a crime, connivance to crimes). Firstly, their legal nature has not always been identified with ways to counteract the administration of justice (in its broad sense, not only as the activity of the court, but also officials, individuals and even collective entities (legal entities) obliged to comply with the law, to promote the administration of justice and to execute judicial acts). Secondly, in certain historical periods, acts of wrongdoing and acts of persons touched were considered as encroachments on other public relations protected by law (for example, legitimate institutions of state power and economic security of the state).
Investigation of Photocatalytic Degradation of Rhodamine B by Using NanoSized TiO2
Authors: D. Kishore Rakhi Goyal,
Published: July 2023

In present work investigation of photocatalytic degradation of Rhodamine B dye has been done using nanosized TiO2. In photocatalytic degradation the decomposition of rhodamine-B dye has been done using UV illumination using TiO2 Nanoparticles. In present work the absorbance of the reaction mixture has been measured at various time intervals using Spectrophotometer. Control experiments confirm the necessity of light, semiconductor catalyst and oxygen to follow the photocatalytic path to proceed the photobleaching of dye. Effect of pH, amount of photocatalyst [TiO2], initial dye concentration has been studied over photocatalytic degradation of Rhodamine B. A tentative mechanism has also been proposed
Genotype and Allele Frequencies of Irritable Bowel Syndrome (IBS)-associated Single Nucleotide Polymorphisms among Malays in Malaysia
Authors: ROSDİ Rasmaizatul Akma , MUSA Nurfadhlina , ZAHARI Zalına , KHAIRI Zahrı , ALFATAMA Mulham , KHOO Boon Yin
Published: July 2023

Aim: Irritable bowel syndrome (IBS) defined by chronic or recurrent abdominal pain or discomfort and changes in bowel habits, is the most common functional gastrointestinal disorder. Studies proved that polymorphisms in the genes were one of the key roles in the underlying IBS. This study aimed to investigate the genotypes and allele frequencies of the IBS-associated single nucleotide polymorphism (SNP) from the genes GNB3 (rs54443) and SCN5A (rs8015124) in unrelated, healthy Malays of Malaysia.
Material and Methods: The genomic DNA of 404 subjects was set to nested, multiplex, and allele-specific PCR to determine the aforementioned SNPs. The PCR results were validated through the Sanger sequencing analysis.
Results: Malays possessed a slightly higher frequency of wild (C) than mutant (T) alleles in the rs5443 with 56.3 vs 43.7%. However, the frequencies of the alleles were equivalent in the subset of Malay females (C-50%, T-50%). For rs1805124, only 18.6% of Malays carried the mutant allele G with less than 10 subjects being homozygous mutant GG carriers. Concurrently, the Hardy-Weinberg equilibrium of the SNPs in the study was not deviated.
Conclusion: IBS is a common gastrointestinal problem that has significantly reduced the life quality of oneself and become an economic burden to societies. Though the mutant alleles were rather low, the IBS-associated polymorphisms, rs5443 and rs1805124 were noted to be commonly present in the Malays. Further research on the local IBS patients is recommended to affirm the association of rs5443 and rs1805124 polymorphisms and the syndrome.
Empirical Evidence of the Relationship Between the SDGs and Economic Growth in Albania: The Role of Education
Authors: Muja Desantila
Published: July 2023

Education is considered as a catalyst for change and sustainable development. While, the Sustainable Development Goals are a universal call to action to face global challenges, especially in developing economies. In this regard, the research intends to empirically investigate the relationship between selected UN SDGs and GDP per capita growth rate as a proxy for economic well-being in Albania, focusing more on the role of education, which places emphasis on the knowledge economy. This study employed the Ordinary Least Square regression model as a statistical technique where GDP per capita growth rate is taken as the dependent variable. The data for the period 2007-2020 were sourced from the World Bank, International Labour Organization, Food and Agriculture Organization and INSTAT. The results show that total government expenditure on education (% of GDP), decent employment and hunger are positively related to the GDP per capita growth. However, decent employment appears to be insignificantly related, while gender equity/women’s empowerment appears to be negatively insignificantly related to the GDP per capita growth rate. The research indicates that education can promote economic and socioeconomic goals, consequently, the Albanian government should invest more in education and training.
Industry 5.0: Guidelines to Digital Transformation as a Strategy for Sustainability
Authors: Oberer Birgit , Erkollar Alptekin
Published: July 2023

Digital transformation involves the integration of digital technologies and solutions into every facet of an organization. However, it's not just about technology, but also requires a cultural shift within the organization. It's a crucial component for any comprehensive business transformation strategy and can be the key to success. By leveraging the right technologies and involving people, processes, and operations, organizations can adapt quickly to change, seize opportunities, meet customer demands, and drive growth and innovation. To ensure long-term sustainability, it's essential to integrate sustainability strategies across various dimensions of the digital transformation roadmap. This paper explores how digital transformation has evolved since the COVID-19 pandemic, the significant challenges that organizations are facing today, what leading organizations are doing differently, and what steps can be taken to identify and address the key areas of focus in the coming years, with an emphasis on the people component as a critical success factor.
Youth Clusters in the Field of Digitalization
Authors: Kurucz Attila , Dernóczy-Polyák Adrienn , Osieczko-Potoczna Kornelia
Published: July 2023

This paper focuses on the new values of the digital age which impact the decisions of customers and influence attitudes towards technology and products. The research aimed to identify some typical groups among millennials. The research was carried out in Hungary and in Poland. We generalized the results based on their attitudes, feelings and behavior. According to the responses of more than 2000 young people this study presents the different clusters of the Y generation in their purchasing behavior and preferred digital values. We categorized them based on their opinions and profiled them using other demographic features. Environmental protection, health and safety were proven values and therefore important; digital solutions or the new products of industry 4.0 are examined in more in detail. With these clusters the economic role-players can gain insight into the differences between each consumer group and how to fulfil their needs regarding sustainable services and goods.
Impact of Music Therapy on Quality of Life of Children With Cancer
Authors: Fedhila Faten , Hannachi Mohamed Wassim , Jbebli Elhem , Selmi Ines , Rhayem Samar , Magouri Issam , Bellali Hedia , Khemiri Monia
Published: July 2023

Background: Music therapy (MT) is a non-pharmacological treatment increasingly used to reduce stress and anxiety in hospitalized children affected by cancers. The aim of this study was to eval-uate the impact of MT on quality of life of children with cancer. Methods: We have conducted a quasi-experimental study between April 1 and August 31, 2021 at Bechir Hamza children's Hos-pital in Tunis, including children treated for cancer. The child or the parent completed PedsQL Module Cancer french version 3.0 questionnaires before and after four weekly music therapy ses-sions. Child's respiratory and heart rate were measured before and after each session. Results: We included 20 children whose mean age was 7 ± 4.5 years [2-14]. The median value of the total questionnaire score increased from 57 [46; 70] to 72 [67; 85] (p < 10-3) with a significant reduction in pain (p = 0.02), nausea (p = 0.009), anxiety related to medical procedures (p = 0.009) and worry about the future (p = 0.005). We highlighted a significant decrease in respiratory and heart rate after MT (p<0,05). Conclusions: MT has positive impact of on quality of life of children with cancer.
A cost-effective approach utilizing a natural biosorbent phase for determining emerging contaminants in water through disposable pipette extraction
Authors: khazri HASSEN , Hamdi Abdelwahab
Published: July 2023

In this work, a novel cork powder-based biosorbent is applied and packed into a micropipette tip for the extraction of trace emerging contaminants prior to their detection by high-performance liquid chromatography (HPLC). The morphology and structure of adsorbent material was characterized by field emission scanning electron microscopy the morphology and composition of the cork powder were characterized using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and N2 adsorption. The parameters including the amount of adsorbent, sampling volume, sampling rate, sample pH, and desorption solvent affected the extraction performance was systematically investigated by pipette tip solid-phase extraction (PT-SPE) coupled with HPLC analysis. Under the optimized condition, the linearity of this method ranged from 1 to 200 µg.mL-1 for compounds with determination coefficient higher than 0.96. The limit of detection (at a signal-to-noise ratio of 3) were in the range 0.38–0.83 µg.mL-1. The relative recoveries of the analytes from spiked samples ranged from 71.8–104.7%, with relative standard deviations less than 5.7%. The filled extraction tube exhibited good stability and reproducibility. The proposed method has been successfully used to detect compounds in water with satisfactory recoveries.
Non-Myelotoxic Agents as a Preparatory Regimen for Hematopoietic Stem Cell Gene Therapy
Authors: ŞEKER Mehmet Emin , EROL Özgür Doğuş , PERVİN Burcu , Wagemaker Gerard , Til Niek Peter van , Aerts-Kaya Fatima
Published: July 2023

RAG2 deficiency is characterized by a lack of B and T lymphocytes, causing severe lethal infections. Currently, RAG2 deficiency is treated with a Hematopoietic Stem Cell transplantation (HSCT). Most conditioning regimens used before HSCT consist of alkylating myelotoxic agents with or without irradiation and affect growth and development of pediatric patients. Here, we developed a non-myelotoxic regimen using G-CSF, VLA-4I or AMD3100. These agents are known HSC mobilizers or affect bone marrow (BM) permeability and may support the homing of HSCs to the BM, without inducing major side effects. Female Rag2-/- mice were pre-treated with Busulfan (BU), G-CSF, VLA-4I or AMD3100 and transplanted with male BM cells transduced with a lentiviral vector carrying codon optimized human RAG2 (RAG2co). Peripheral blood cell counts increased significantly after G-CSF, VLA-4I and AMD3100 treatment, but not after BU. Reconstitution of PB lymphocytes was comparable for all groups with full immune reconstitution at 6 months post transplantation, despite different methods of conditioning. Survival of mice pre-treated with non-myelotoxic agents was significantly higher than after BU treatment. Here we show that the non-myelotoxic agents G-CSF, VLA-4I, and AMD3100 are highly effective as conditioning regimen before HSC gene therapy and can be used instead of BU.
Comparison of the Prevalence of Malocclusion and Oral Habits Between Children with Cerebral Palsy and Healthy Children
Authors: Almotareb Fuad Lutf , Al-Shamahy Hassan A.
Published: July 2023

Background
Cerebral palsy (CP) represents for children an important problem of health and affects roughly 2 per 1000 live births and is the most common pediatric developmental motor disability. Therefore, the purpose of this study was to determine the prevalence, type and severity of malocclusion and oral habits in children with Cerebral Palsy (CP) and to compare them with a control group of healthy children in Sana’a city.
Material and Methods
A prospective, case–control study was made of two groups, a cerebral palsy and a control group. The study population consisted of 60 children who had CP, and a control group of 60 matched children who had no known physical or mental handicap. Data were collected using a questionnaire and assessment for malocclusion was done clinically. The patients were compared with equal number of age-matched controls. The inclusion criteria were individuals aged over 6 years; absence of previous orthodontic treatment; no missing permanent first molars
Results
Results showed an increased prevalence of malocclusion in children with cerebral palsy. Molar class II relationship was statistically higher in cerebral palsy children than healthy control (P = 0.001). Cerebral palsied children are likely to have a significantly increased protrusion of the anterior teeth (P < 0.001) when compared with normal children. Mouth breathing and Tongue thrust. Habits were significantly higher in the CP group (p = 0.0001) when compared with normal children.
Conclusion
The prevalence of malocclusion was higher in children with Cerebral palsy than in normal children, and the present study concludes that in children with Cerebral Palsy, more oral Habits problems due to oral motor dysfunctions are common and problems of mouth breathing and Tongue thrust produce different malocclusion and poor oral hygiene complications in these children.
Oritavancin as Sequential Therapy for Gram-positive Bloodstream Infections
Authors: Texidor Williams Monier , Miller Matthew A. , Molina Kyle C. , Krsak Martin , Calvert Barbara , Hart Caitlin , Storer Marie , Fish Douglas N.
Published: July 2023

Background
Oritavancin, a long-acting lipoglycopeptide approved for use in acute bacterial skin and skin structure infections, has limited data evaluating use in serious infections due to Gram-positive organisms. We aimed to assess the effectiveness and safety of oritavancin for consolidative treatment of Gram-positive bloodstream infections (BSI), including infective endocarditis (IE).
Methods
We conducted a retrospective cohort evaluating adult patients admitted to University of Colorado Hospital from March 2016 to January 2022 who received ≥ 1 oritavancin dose for treatment of Gram-positive BSI. Patients were excluded if the index culture was drawn at an outside facility or were > 89 years of age. The primary outcome was a 90-day composite failure (clinical or microbiological failure) in those with 90-day follow-up. Secondary outcomes included individual components of the primary outcome, acute kidney injury (AKI), infusion-related reactions (IRR), and institutional cost avoidance.
Results
Overall, 72 patients were included. Mean ± SD age was 54 ± 16 years, 61% were male, and 10% had IE. Organisms most commonly causing BSI were Staphylococcus aureus (68%, 17% methicillin-resistant), followed by Streptococcus spp. (26%), and Enterococcus spp. (10%). Patients received standard-of-care antibiotics before oritavancin for a median (IQR) of 11 (5–17) days. Composite failure in the clinically evaluable population (n = 64) at 90-days occurred in 14% and was composed of clinical and microbiological failure, which occurred in 14% and 5% of patients, respectively. Three patients (4%) experienced AKI after oritavancin, and two (3%) experienced an IRR. Oritavancin utilization resulted in earlier discharge for 94% of patients corresponding to an institutional cost-avoidance of $3,055,804 (mean $44,938/patient) from 1,102 hospital days saved (mean 16 days/patient).
Conclusions
The use of oritavancin may be an effective sequential therapy for Gram-positive BSI to facilitate early discharge resulting in institutional cost avoidance.
Prevalence and Risk Factors of Obesity among Undergraduate Student Population in Ghana: An Evaluation Study of Body Composition Indices
Authors: Obirikorang Christian , Adu Evans Asamoah , Anto Enoch Odame , Awuah Anthony Afum-Adjei , Fynn Angela Nana Bosowah , Osei-Somuah George , Ansong Patience Nyarkoa , Boakye Alexander Owusu , Boadu Ivy Ofori , Obirikorang Yaa , Adobasom-Anane Austin Gideon , Nyarko Eric NY , Balmer Lois
Published: July 2023

Background
Obesity is a classified risk factor for several of the world’s leading causes of death. In this study, we combined information contained in body mass index (BMI), total percentage body fat (TPBF) and relative fat mass (RFM) to estimate obesity prevalence.
Methods
The study recruited 1027 undergraduate students aged between 16–25 years using a cross-sectional study design and two-stage stratified random sampling. Demographic, lifestyle, and family history of chronic disease data, were collected using a structured questionnaire. Bioelectrical impedance, along with height, weight, age, and gender, was used to estimate BMI and TPBF. RFM was calculated using a published equation. TPBF and RFM ranges were evaluated based on standard BMI thresholds and an informative combined obesity prevalence estimated in a Bayesian framework. Multiple logistic regression analysis was used to evaluate risk factors.
Results
Concordance between BMI, TPBF and RFM for obesity classification was 84% among female and 82.9% among male students. The Bayesian analysis revealed a combined prevalence means of obesity of 9.4% (95%CI: 6.9%-12.2%) among female students and 6.7% (95%CI:4.3%-9.5%) among male students. The odds of obesity were increased between 1.8 and 2.5 for females depending on the classification index. A significant increasing trend of obesity was observed with university-level. A family history of obesity was associated with a high estimate of general, central, and high TPBF.
Conclusion
Using multiple adiposity indicators conjointly in a Bayesian framework offers a greater power to examine obesity prevalence. We have applied this and reported high obesity prevalence, especially among female students. University level and family history of obesity were key determinants for obesity among the student population.
Dynamics, stability and bifurcations of a planar three-link swimmer with passive visco-elastic joint using “ideal fluid” model
Authors: Tovi Elon , Zigelman Anna , Or Yizhar
Published: July 2023

Articulated swimming robots have a promising potential for various marine applications. A common theoretical model assumes ideal fluid, where the viscosity is negligible and the swimmer-fluid interaction is induced by reactive forces originating from added mass effect. Some previous works used this model to study planar multi-link swimmers under kinematic input prescribing all joint angles. Inspired by biological swimmers in nature that utilize body flexibility, in this work we consider an underactuated three-link swimmer where one joint is periodically actuated while the other joint is passive and viscoelastic. Analysis of the swimmer’s nonlinear dynamics reveals that its motion depends significantly on the amplitude and frequency of the actuated joint angle. Optimal frequency is found where the swimmer’s net displacement per cycle is maximized, under symmetric periodic oscillations of the passive joint. In addition, upon crossing critical values of amplitude or frequency, the system undergoes a bifurcation where the symmetric periodic solution loses stability and asymmetric solutions evolve, for which the swimmer moves along an arc. We analyze these phenomena using numerical simulations and analytical methods of perturbation expansion, harmonic balance, Floquet theory and Hill’s determinant. The results demonstrate the important role of parametric excitation in stability and bifurcations of motion for flexible underactuated locomotion.
The Role of Probiotic in Psoriasis Treatment: A Meta-Analysis of Randomized Controlled Clinical Trials
Authors: Umborowati Menul Ayu , Rosita Primadita Esther , Endaryanto Anang , Surono Ingrid S , Thio Hok Bing , Prakoeswa Cita Rosita Sigit
Published: July 2023

Backgrounds: The body of knowledge about the pathogenesis and treatment of psoriasis is expanding. Several recent studies have suggested a link between dysbiosis in the gut microbiome and the occurrence of psoriasis. Probiotics are thought to treat gut microbiome dysbiosis.
Methods: The literature included randomized control trials (RCT) studies published between January 2003 and June 2022 and found in three databases. Review Manager 5.4 software was used for statistical analysis.
Results:This meta-analysis study included 4 RCT articles involving 212 adults. This study’s RCTs all compared oral probiotics to a placebo. For the clinical improvement outcome, this study showed that the probiotic group had 1.82 times higher risk of recovery than the placebo group (P < 0.05). C-reactive Protein levels were found to be 1.25 times lower in patients who received probiotic supplementation (P < 0.05). Meanwhile, a study on Interleukin 6 (IL-6) levels found that probiotic supplementation reduced serum IL-6 levels by 1.28 times, but this was not statistically significant (P= 0.35).
Conclusion: Oral probiotic supplementation may be beneficial for psoriasis treatment because it reduces clinical severity and inflammation.
On vulnerabilities in EVT-based timing analysis: an experimental investigation on a multi-more architecture
Authors: Vasconcelos Jamile , Lima George , Khazen Marwan Wehaiba El , Gogonel Adriana , Cucu-Grosjean Liliana
Published: July 2023

Hardware architectures equipped with multiple cores, cache memory and branch prediction usually preclude the application of classical methods for determining execution time bounds for real-time tasks. As such bounds are fundamental in the designing of real-time systems, Measurement-Based Probabilistic Timing Analysis (MBPTA) has been employed. A common choice is the derivation of probabilistic Worst-Case Execution Time (pWCET) via the use of Extreme Value Theory (EVT), a branch of statistics used to estimate the probability of rare events that are more extreme than observations. However, pWCET estimations are usually reported in a controlled or simulated environment. In this paper we apply MBPTA in a real multi-core platform, namely Raspberry Pi 3B, taking into consideration possible interference due to operating system and concurrent activities. The results indicate that although EVT is effective, it does not always produce adequate models and coherent pWCET estimations. As MBPTA is primarily called for when classical methods are not applicable, as it is the case for the studied platform, the results reported in this paper highlight risks and vulnerabilities when applying MBPTA-EVT for pWCET inference.
WITHDRAWN: Environmental Kuznets Curve and Roles of Development Finance in the Global South
Authors: Wang Yan , Xu Yinyin
Published: July 2023

This study investigates the nexus between CO2 emissions, economic development and development finance using a novel dataset for 76 developing countries from 1995 to 2018. Employing a framework of three dimensions, the natural endowment, the real economy and the financial sector, our estimation method takes into account the bi-directional causality of the environmental delegation and economic growth by adopting the simultaneous equations model estimated via fixed effect 2SLS. In the tradition of the environment Kuznets curves (EKC), we found an inverted N-shaped EKC relationship in the panel data which is statistically significant and robust. On development finance, net transfers from bilateral and multilateral banks are not directly associated with environmental degradation. The green natural capital is negatively and statistically significantly associated with the CO2 emissions density, providing some evidence for the existence of the “biological carbon sequestration” effect. Our results provide insights to enhance the effectiveness of future development finance, e.g. to renewable energy, investment in human capital and green natural capital.
Haze prediction research based on PSO-CPU-GPU heterogeneous parallel support vector regression machine
Authors: Liu Zuhan , Zhao Kexin , Liu Xuehu , Xu Huan
Published: July 2023

Human life and development are affected by air quality, which means it is significant to accurately estimate air quality utilizing science. Considering PM2.5 is an essential component of air pollution, accurate PM2.5 prediction is crucial to maintaining air quality, preserving human wellness, and advancing urbanization's sustainability and scientific evolution. In this investigation, we provide a Particle Swarm Optimization (PSO) and Central Processing Unit-Graphics Processing Unit (CPU-GPU) heterogeneous parallel Support vector regression (SVR) method to forecast the airborne PM2.5 content. The approach enhances computational effectiveness, accelerates solution times, and satisfies debugging and application requirements in realistic circumstances where the size and dimensionality of the pertinent data are increasing. by contrasting it with conventional support vector regression methods and conducting analysis of variance on various data sets. The simulation results demonstrate a rise of over fifty per cent in prediction speed with a high degree of accuracy for the CPU-GPU heterogeneous parallel support vector regression (PSO-CPU-GPU-SVR) model.
Three-Dimensional Reconstruction of Ribs Based on Point Cloud Adaptive Smoothing Denoising
Authors: He Bishi , Wang Diao , Chen Yuanjiao , Xu Zhe , Zhu Darong
Published: July 2023

The traditional methods for 3D reconstruction mainly involve using image processing techniques or deep learning segmentation models for rib extraction. After post-processing, voxel-based rib reconstruction is achieved. However, these methods suffer from limited reconstruction accuracy and low computational efficiency. To overcome these limitations, this paper proposes a rib 3D reconstruction method based on point cloud adaptive smoothing and denoising. We convert the voxel data from the CT images to multi-attribute point cloud data. Then, we apply point cloud adaptive smoothing and denoising methods to eliminate noise and non-rib points in the point cloud. Additionally, efficient 3D reconstruction and post-processing techniques are employed to achieve high-accuracy and comprehensive rib 3D reconstruction results. Experimental calculations demonstrate that compared to voxel-based rib 3D reconstruction methods, the rib 3D models generated by the proposed method achieve a 40% improvement in reconstruction accuracy and are twice as efficient as the former.