bluuebunny/crossref_metadata_2025 huggingface dataset:
Research progress of the detection and analysis methods of heavy metals in plants
Authors: He Shuang , Niu Yuting , Xing Lu , Liang Zongsuo , Song Xiaomei , Ding Meihai , Huang Wenli
Published: January 2024

Heavy metal (HM)-induced stress can lead to the enrichment of HMs in plants thereby threatening people’s lives and health via the food chain. For this reason, there is an urgent need for some reliable and practical techniques to detect and analyze the absorption, distribution, accumulation, chemical form, and transport of HMs in plants for reducing or regulating HM content. Not only does it help to explore the mechanism of plant HM response, but it also holds significant importance for cultivating plants with low levels of HMs. Even though this field has garnered significant attention recently, only minority researchers have systematically summarized the different methods of analysis. This paper outlines the detection and analysis techniques applied in recent years for determining HM concentration in plants, such as inductively coupled plasma mass spectrometry (ICP-MS), atomic absorption spectrometry (AAS), atomic fluorescence spectrometry (AFS), X-ray absorption spectroscopy (XAS), X-ray fluorescence spectrometry (XRF), laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS), non-invasive micro-test technology (NMT) and omics and molecular biology approaches. They can detect the chemical forms, spatial distribution, uptake and transport of HMs in plants. For this paper, the principles behind these techniques are clarified, their advantages and disadvantages are highlighted, their applications are explored, and guidance for selecting the appropriate methods to study HMs in plants is provided for later research. It is also expected to promote the innovation and development of HM-detection technologies and offer ideas for future research concerning HM accumulation in plants.
Perception of robotic actions and the influence of gender
Authors: Abel Miriam , Buccino Giovanni , Binkofski Ferdinand
Published: January 2024

In our society interaction with robots is becoming more and more frequent since robots are not only used in the industry, but increasingly often in assistance and in health system. Perception of robots and their movements is crucial for their acceptance. Here we shortly review basic mechanisms of perception of actions, and then of perception of robotic and human movements. The literature demonstrates that there are commonalities, but also differences in the perception of human and robotic movements. Especially interesting are biologic gender differences in the perception of robotic movements. The results show that males seem to be more sensitive to the differences between robotic and anthropomorphic movements, whereas females seem not to perceive such differences. However, females transfer more anthropomorphic features to robotic movements. While looking at the brain activation during perception of humanoid and robotic movements in different genders one can conclude that different strategies are used; female seem to analyse robotic movements online, while male seem to use previous knowledge from interaction with robots. Further research is needed to specify more such gender differences.
Child-adolescent emergency psychiatry: addressing false positive admissions
Authors: Isaac Linda , Sutton Tiphanie , Kahlon Jasmine , Pathania Pratima S. , Wolf Bradley L. , Pearce Ryan , Chan Helen Iat Chio , Zils Matthew J.
Published: January 2024

Current literature emphasizes the necessary and increasing role of the emergency department (ED) psychologist. This perspective paper will illustrate that the recent focus on an ED psychologist is necessary, but insufficient. Equally important, is an understanding of when a patient in a potential crisis does not require an ED admission, but rather an assessment that is made prior to the patient going to the ED. The essential role of an outpatient crisis team is vital in differentiating when an ED admission is indicated for a psychiatric crisis (true positive) and when an ED admission is not indicated for a psychiatric crisis (false positive). Evaluating crises prior to ED admissions accomplishes two critical healthcare objectives in a parallel process: 1) accurately assessing the proper level of care needed when a patient reports they are experiencing acute psychiatric symptoms (which may or may not necessitate emergency department level of care, and 2) reducing burden on an already over-extended ED when emergency care is not indicated. Our findings are uniquely drawn from a highly diverse youth patient population in Northern California, United States.
Increased risk of acute stress disorder and post-traumatic stress disorder in children and adolescents with autism spectrum disorder: a nation-wide cohort study in Taiwan
Authors: Li Sung-Tao , Chien Wu-Chien , Chung Chi-Hsiang , Tzeng Nian-Sheng
Published: January 2024

Introduction

Children and adolescents with autism spectrum disorder (ASD) may be particularly vulnerable to the impact of traumatic events, yet the association between ASD and the risk of developing acute stress disorder and post-traumatic stress disorder (PTSD) remains uncertain. This study aims to investigate this association, addressing the gap in large-scale evidence on the subject.

Methods

Conducted as a retrospective and matched cohort study, data was sourced from the National Health Insurance Research Database (NHIRD) in Taiwan, spanning from January 1, 2000, to December 31, 2015. The study included patients aged 18 years or under newly diagnosed with ASD (n=15,200) and compared them with a matched control group (n=45,600). The Cox proportional regression model was employed to assess the risk of acute stress disorder and PTSD.

Results

Over the 15-year follow-up period, a total of 132 participants developed either acute stress disorder or PTSD. Among them, 105 cases (0.691% or 64.90 per 100,000 person-years) were in the ASD group, while 27 cases (0.059% or 5.38 per 100,000 person-years) were in the control group. The adjusted hazard ratio for the ASD group was significantly higher compared to the control group (25.661 with 95% CI = 15.913-41.232; P < .001).

Discussion

This study provides compelling evidence that individuals with ASD face an elevated risk of developing acute stress disorder and PTSD. The findings underscore the importance of clinicians recognizing and addressing this vulnerability in ASD individuals exposed to traumatic events. This emphasizes the need for heightened attention to the risk of PTSD and acute stress disorder in the ASD population.
Forging the Future: Strategic Approaches to Quantum AI Integration for Industry Transformation
Authors: How Meng-Leong , Cheah Sin-Mei
Published: January 2024

The fusion of quantum computing and artificial intelligence (AI) heralds a transformative era for Industry 4.0, offering unprecedented capabilities and challenges. This paper delves into the intricacies of quantum AI, its potential impact on Industry 4.0, and the necessary change management and innovation strategies for seamless integration. Drawing from theoretical insights and real-world case studies, we explore the current landscape of quantum AI, its foreseeable influence, and the implications for organizational strategy. We further expound on traditional change management tactics, emphasizing the importance of continuous learning, ecosystem collaborations, and proactive approaches. By examining successful and failed quantum AI implementations, lessons are derived to guide future endeavors. Conclusively, the paper underscores the imperative of being proactive in embracing quantum AI innovations, advocating for strategic foresight, interdisciplinary collaboration, and robust risk management. Through a comprehensive exploration, this paper aims to equip stakeholders with the knowledge and strategies to navigate the complexities of quantum AI in Industry 4.0, emphasizing its transformative potential and the necessity for preparedness and adaptability.
Exploration of Wendan Pomelo (Citrus maxima (Burm.) Merr. cv. Wentan) Peel from Four Different Growing Regions by Liquid Chromatography–Mass Spectrometry and Bioactivity Analysis
Authors: Lu Jinlan , Wang Wenshu
Published: January 2024

Wendan (a type of pomelo), a popular fruit in China, is less known in other countries. Its peel is widely used in food and traditional medicine. Four different origins (Xuzhou, Taizhou, Zhangzhou, and Meizhou) of Wendan pomelo were selected, and crude extracts were obtained by the Soxhlet extraction method. The composition of Wendan peel was analyzed by high-performance liquid chromatography–mass spectrometry (HPLC-MS) in positive ion mode. The compounds were identified by searching the Metabolite Link (METLIN), the Spectral Database for Organic Compounds (SDBS), and by referring to literature reports. A total of 20 compounds were identified among the samples from the four origins, of which 8 compounds were common. The majority of the compounds belonged to the flavonoid and coumarin classes; Meranzin hydrate was identified for the first time in pomelo peel. In vitro antioxidant activity experiments showed that samples from Taizhou, Zhejiang, exhibited the highest antioxidant activity in the DPPH, ABTS, and FRAP assays, with values of 0.59 mg/mL, 97.06 μmol TE/g, and 60.62 μmol Fe2+/g, respectively. Samples from Zhangzhou, Fujian, showed antioxidant activity second only to the samples from Taizhou, Zhejiang. The sample from Zhangzhou, Fujian Province, showed excellent inhibitory activity in the α-glucosidase inhibition assay (IC50 = 7.99 mg/mL).
Structural Characterization and Immunomodulatory Activity of an Exopolysaccharide Produced by Probiotic Leuconostoc mesenteroides 201607 Isolated from Fermented Food
Authors: Vijayalakshmi Selvakumar , Kim Jong-Rai , Chelliah Ramachandran , Barathikannan Kaliyan , Hirad Abdurahman Hajinur , Oh Deog-Hwan
Published: January 2024

Fermented foods containing probiotic Leuconostoc mesenteroides 201607 (LM) were used to extract exopolysaccharides. An incomplete understanding exists regarding the immunomodulatory characteristics of exopolysaccharides (EPSs), which are important constituents of bacterial biofilms. In this instance, we examined the immunomodulatory capacity of EPSs from fermented food extracted from L. mesenteroides 201607. Partially purified exopolysaccharide from L. mesenteroides 201607 (PP-LMEPS) consists of glucose (57.1%), rhamnose (29.53%), and galactose (13.36%). The maximum EPS yield was attained after 30 h of incubation at 37 °C and an initial pH of 7.0. When lipopolysaccharide-stimulated RAW264.7 was exposed to PP-LMEPS, the inflammatory cytokines were considerably decreased or elevated dose-dependently. Upon the exposure of lipopolysaccharide-stimulated RAW264.7 cells to PP-LMEPS, a dose-dependent modulation of inflammatory cytokines was observed. This suggests that the extracted EPS possesses immunomodulatory characteristics, as evidenced by a significant decrease or increase in inflammatory cytokine levels. However, further research is warranted to fully elucidate the precise mechanisms and potential therapeutic implications of the immunomodulatory properties of PP-LMEPS.
Artificial Intelligence Analysis and Reverse Engineering of Molecular Subtypes of Diffuse Large B-Cell Lymphoma Using Gene Expression Data
Authors: Carreras Joaquim , Yukie Kikuti Yara , Miyaoka Masashi , Miyahara Saya , Roncador Giovanna , Hamoudi Rifat , Nakamura Naoya
Published: January 2024

Diffuse large B-cell lymphoma is one of the most frequent mature B-cell hematological neoplasms and non-Hodgkin lymphomas. Despite advances in diagnosis and treatment, clinical evolution is unfavorable in a subset of patients. Using molecular techniques, several pathogenic models have been proposed, including cell-of-origin molecular classification; Hans’ classification and derivates; and the Schmitz, Chapuy, Lacy, Reddy, and Sha models. This study introduced different machine learning techniques and their classification. Later, several machine learning techniques and artificial neural networks were used to predict the DLBCL subtypes with high accuracy (100–95%), including Germinal center B-cell like (GCB), Activated B-cell like (ABC), Molecular high-grade (MHG), and Unclassified (UNC), in the context of the data released by the REMoDL-B trial. In order of accuracy (MHG vs. others), the techniques were XGBoost tree (100%); random trees (99.9%); random forest (99.5%); and C5, Bayesian network, SVM, logistic regression, KNN algorithm, neural networks, LSVM, discriminant analysis, CHAID, C&R tree, tree-AS, Quest, and XGBoost linear (99.4–91.1%). The inputs (predictors) were all the genes of the array and a set of 28 genes related to DLBCL-Burkitt differential expression. In summary, artificial intelligence (AI) is a useful tool for predictive analytics using gene expression data.
Prognostic Factors and Nomogram for Choroid Plexus Tumors: A Population-Based Retrospective Surveillance, Epidemiology, and End Results Database Analysis
Authors: Bhutada Abhishek S. , Adhikari Srijan , Cuoco Joshua A. , In Alexander , Rogers Cara M. , Jane John A. , Marvin Eric A.
Published: January 2024

Background: Choroid plexus tumors (CPTs) are rare neoplasms found in the central nervous system, comprising 1% of all brain tumors. These tumors include choroid plexus papilloma (CPP), atypical choroid plexus papilloma (aCPP), and choroid plexus carcinoma (CPC). Although gross total resection for choroid plexus papillomas (CPPs) is associated with long-term survival, there is a scarcity of prospective data concerning the role and sequence of neoadjuvant therapy in treating aCPP and CPC. Methods: From the years 2000 to 2019, 679 patients with CPT were identified from the Surveillance, Epidemiology, and End Result (SEER) database. Among these patients, 456 patients had CPP, 75 patients had aCPP, and 142 patients had CPC. Univariate and multivariable Cox proportional hazard models were run to identify variables that had a significant impact on the primary endpoint of overall survival (OS). A predictive nomogram was built for patients with CPC to predict 5-year and 10-year survival probability. Results: Histology was a significant predictor of OS, with 5-year OS rates of 90, 79, and 61% for CPP, aCPP, and CPC, respectively. Older age and African American race were prognostic for worse OS for patients with CPP. Older age was also associated with reduced OS for patients with aCPP. American Indian/Alaskan Native race was linked to poorer OS for patients with CPC. Overall, treatment with gross total resection or subtotal resection had no difference in OS in patients with CPP or aCPP. Meanwhile, in patients with CPC, gross total resection (GTR) was associated with significantly better OS than subtotal resection (STR) only. However, there is no difference in OS between patients that receive GTR and patients that receive STR with adjuvant therapy. The nomogram for CPC considers types of treatments received. It demonstrates acceptable accuracy in estimating survival probability at 5-year and 10-year intervals, with a C-index of 0.608 (95% CI of 0.446 to 0.77). Conclusions: This is the largest study on CPT to date and highlights the optimal treatment strategies for these rare tumors. Overall, there is no difference in OS with GTR vs. STR in CPP or aCPP. Furthermore, OS is equivalent for CPC with GTR and STR plus adjuvant therapy.
Designing and Manufacturing of Biocompatible Hydroxyapatite and Sodium Trisilicate Scaffolds by Ordinary Domestic Microwave Oven
Authors: Luciano Giorgio , Vignolo Maurizio , Galante Denise , D’Arrigo Cristina , Furlani Franco , Montesi Monica , Panseri Silvia
Published: January 2024

In this work, we present a versatile, rapid, and low-cost manufacturing technique to develop bioceramic scaffolds that could enhance bone tissue regeneration via microwave preparation using a domestic microwave oven. The scaffolds were prepared by combining hydroxyapatite and water glass (sodium trisilicate solution), foamed by using a microwave oven, and then characterized by means of Scanning Electron Microscopy (SEM) with Energy Dispersive X-ray Analysis (EDX), mechanical properties, infrared spectroscopy (ATR-FTIR), and a density and stability test in water. Furthermore, in vitro tests were performed to verify the affinity of the scaffold for osteoclast cells. The morphology of the samples showed interconnected pores suitable for promoting tissue regeneration and vascularization, while specific mechanical properties were preserved. The physicochemical characterization and the in vitro tests presented promising results for bone regenerative applications. The scaffolds we obtained exhibited comparable properties to those fabricated using a laboratory microwave oven, including the ability to induce the formation of bone-like tissue in vitro.
“The Ability to Go Out into the World Is the Most Important Thing”—A Qualitative Study of Important Exercise Outcomes for People with Lung Cancer
Authors: Bowman Amy , Denehy Linda , McDonald Cassie E. , Edbrooke Lara
Published: January 2024

Whilst existing quantitative research identifies outcomes believed to be important by researchers and clinicians, it may neglect outcomes that are meaningful to patients. This study aimed to explore the outcomes of exercise that are important to people with lung cancer and their carers. Data collection involved a qualitative methodology including semi-structured interviews and focus groups. Question guide development was informed by the International Classification of Functioning (ICF) framework. Data were analyzed by two researchers with NVivo (v12) software using a conventional content analysis process, followed by directed content analysis to map outcomes to the ICF. Conduct and reporting adhered to COREQ guidelines. Fifteen participants provided data. Most participants had received their diagnoses 24 months prior to study involvement (n = 9), and one-third had completed treatment (n = 5). Important outcomes were reported by participants across all domains of the ICF: activity and participation (n = 24), body function (n = 19), body structure (n = 5), environmental factors (n = 5), and personal factors (n = 1). Additional code categories pertained to the impacts of non-cancer factors such as age, frailty, and comorbidities; identifying barriers to exercise; and individualizing outcome measures. Clinicians and researchers should consider selecting outcomes from all relevant domains of the ICF, with a focus on the activity and participation domain, in addition to non-cancer factors such as ageing, frailty, and co-morbidities. Feedback should be provided to patients following outcome measures collection and reassessment.
Improved Chambadal Model with New Optimization Results
Authors: Feidt Michel , Costea Monica
Published: January 2024

This paper presents a continuation of the Chambadal model optimization of the irreversible Carnot engine. We retrieved the results presented in the Special Issue “Carnot Cycle and Heat Engine Fundamentals and Applications II” and enriched them with new contributions that allowed comparing two points of view: (1) the now classical one, centered on entropy production in the four processes of the cycle, which introduces the action of entropy production, with several sequential optimizations; (2) the new one that is relative to an energy degradation approach. The same démarche of sequential optimization was used, but the results were slightly different. We estimate that the second approach is more representative of physics by emphasizing the energy conservation and the existence on an upper and a lower bound in the mechanical energy and power output of the engine.
Quantum State Reduction of General Initial States through Spontaneous Unitarity Violation
Authors: Mukherjee Aritro , Gotur Srinivas , Aalberts Jelle , van den Ende Rosa , Mertens Lotte , van Wezel Jasper
Published: January 2024

The inability of Schrödinger’s unitary time evolution to describe the measurement of a quantum state remains a central foundational problem. It was recently suggested that the unitarity of Schrödinger dynamics can be spontaneously broken, resulting in measurement as an emergent phenomenon in the thermodynamic limit. Here, we introduce a family of models for spontaneous unitarity violation that apply to generic initial superpositions over arbitrarily many states, using either single or multiple state-independent stochastic components. Crucially, we show that Born’s probability rule emerges spontaneously in all cases.
Node-Wise Monotone Barrier Coupling Law for Formation Control
Authors: Lee Jin Gyu , Mostajeran Cyrus , Goffrier Graham Van
Published: January 2024

We study a node-wise monotone barrier coupling law, motivated by the synaptic coupling of neural central pattern generators. It is illustrated that this coupling imitates the desirable properties of neural central pattern generators. In particular, the coupling law (1) allows us to assign multiple central patterns on the circle and (2) allows for rapid switching between different patterns via simple ‘kicks’. In the end, we achieve full control by partitioning the state space by utilizing a barrier effect and assigning a unique steady-state behavior to each element of the resulting partition. We analyze the global behavior and study the viability of the design.
Control Strategies and Stabilization Techniques for DC/DC Converters Application in DC MGs: Challenges, Opportunities, and Prospects—A Review
Authors: Nduwamungu Aphrodis , Lie Tek Tjing , Lestas Ioannis , Nair Nirmal-Kumar C. , Gunawardane Kosala
Published: January 2024

DC microgrids (DC MGs) offer advantages such as efficiency, control, cost, reliability, and size compared to AC MGs. However, they often operate with numerous constant power loads (CPLs), exhibiting a negative incremental impedance characteristic that can lead to instability. This instability weakens stability boundaries and reduces system damping, especially when dealing with pulsed power loads (PPLs) on electric aircraft, ships, and cars. Linear controllers may not ensure stability across various operations, causing voltage dips and potential system instability. To secure DC/DC converter functionality and comply with impedance specifications, it is crucial to consider minor loop gain in control strategies and stabilization techniques. Employing diverse methods to decrease minor loop gain in DC/DC converters is essential. A comprehensive evaluation, including strengths, weaknesses, opportunities, and threats (SWOT) analysis, is conducted to assess control strategies, stabilization techniques, and stability standards for different DC/DC converters, identifying SWOT.
Data Fusion and Ensemble Learning for Advanced Anomaly Detection Using Multi-Spectral RGB and Thermal Imaging of Small Wind Turbine Blades
Authors: Memari Majid , Shekaramiz Mohammad , Masoum Mohammad A. S. , Seibi Abdennour C.
Published: January 2024

This paper introduces an innovative approach to Wind Turbine Blade (WTB) inspection through the synergistic use of thermal and RGB imaging, coupled with advanced deep learning techniques. We curated a unique dataset of 1000 thermal images of healthy and faulty blades using a FLIR C5 Compact Thermal Camera, which is equipped with Multi-Spectral Dynamic Imaging technology for enhanced imaging. This paper focuses on evaluating 35 deep learning classifiers, with a standout ensemble model combining Vision Transformer (ViT) and DenseNet161, achieving a remarkable 100% accuracy on the dataset. This model demonstrates the exceptional potential of deep learning in thermal diagnostic applications, particularly in predictive maintenance within the renewable energy sector. Our findings underscore the synergistic combination of ViT’s global feature analysis and DenseNet161’s dense connectivity, highlighting the importance of controlled environments and sophisticated preprocessing for accurate thermal image capture. This research contributes significantly to the field by providing a comprehensive dataset and demonstrating the efficacy of several deep learning models in ensuring the operational efficiency and reliability of wind turbines.
Feasibility and Challenges for Vehicle-to-Grid in Electricity Market: A Review
Authors: Wan Muchun , Yu Heyang , Huo Yingning , Yu Kan , Jiang Quanyuan , Geng Guangchao
Published: January 2024

Electric vehicles (EVs) play a crucial role in the global transition towards decarbonization and renewable energy resources (RERs). As EVs gain popularity, this has resulted in various challenges for the power grid, such as an intensified peak-to-valley load differential, causing transformer overloading. Vehicle-to-grid (V2G) technology has emerged as a promising solution due to its controllable charging and discharging capabilities. Mature business schemes can incentivize the development of V2G technology. However, the business schemes of V2G technology are still unclear. Therefore, this paper provides a comprehensive review of the business schemes associated with V2G technology, especially focusing on its feasibility and challenges with respect to the electricity market. In this paper, several business schemes with respect to the electricity market are explored by conducting extensive literature reviews, including peak-to-valley arbitrage, the spot market, demand–response (DR), frequency regulation, voltage regulation, spinning reserve, and black start. Next, application scenarios and real-world use cases of the V2G technology’s business schemes are investigated. Furthermore, the challenges faced by the V2G technology’s business schemes are assessed by considering the technical, economical, and social aspects. By identifying these challenges, it is important to highlight the existing shortcomings and areas of interest for V2G technology’s research and development. This review contributes to a deeper understanding of V2G technology and its implications for the energy sector.
Experimental Study on the Effect of Sand and Dust on the Performance of Photovoltaic Modules in Desert Areas
Authors: Liu Xin , Wang Ningbo , Zhao Mingzhi , Hu Xiaoming
Published: January 2024

Photovoltaic power generation is one of the most effective measures to reduce greenhouse gas emissions, and the surface of photovoltaic modules in desert areas is mainly affected by sand erosion and cover, which affect power output. Therefore, a wind–sand erosion system was established to simulate the desert wind–sand environment, analyze the influence of dust erosion on the output power of the component, and observe the surface erosion morphology of the component. Then, dust particles of different sizes were selected to cover the surface of the photovoltaic module, and the temperature change and output characteristics of the backplane of the module were studied. The results show that the erosion rate increases with the increase in the erosion angle. When the erosion rate is 25 m/s and 30 m/s, the output power decreases by 9.82%~16.00% and 15.42%~24.46% at different erosion angles, respectively. As the particle size (0.05 mm~0.30 mm) deposited on the surface of the photovoltaic module gradually increases, the open-circuit voltage of the module changes little, and its maximum difference is 0.25 V. Short-circuit current and output power vary greatly; the maximum difference in short-circuit current is about 13.00%, and the maximum difference in output power is about 17.00%. Through our research, this study provides a certain reference for maximizing power generation efficiency and the clean planning of desert photovoltaic power stations.
Astragalus membranaceus (Huangqi) Supplementation in Sports Training: A Systematic Review
Authors: Antonelli Michele , Donelli Davide
Published: January 2024

The aim of this systematic review is to study the effects of Astragalus membranaceus (Huangqi) supplementation for sports activity and physical performance. PubMed, EMBASE, Web of Science, Cochrane Library, and Google Scholar were systematically searched for relevant studies from inception up until October 2023. Eleven clinical studies were considered eligible for inclusion (six of them involved the administration of Huangqi alone, while, in the remaining trials, this herb was supplemented in combination with other remedies). On average, the number of study participants ranged from 8 to 120, and the sports activities practiced by the subjects included martial arts, mountain hiking, basketball, rowing, running, aerobic exercises, and strength training. When a dried extract was used, Astragalus was taken at a daily dose of 1 to 4 g for several weeks. Huangqi supplementation was associated with improvements in aerobic performance, oxidative status, reticulocytes percentage, and response to acclimatization, without a specific effect on the athletes’ strength. Better post-exercise immune functions were also observed, especially with regard to NK cell activity, IL-2 levels, CD4+/CD8+ ratio, and lymphocyte turnover. No adverse effects were described. In conclusion, Astragalus supplementation has the potential to decrease fatigue, enhance aerobic performance, and mitigate post-exercise immune suppression in athletes. It is advisable to conduct additional research on the subject to enhance the robustness of the existing evidence through larger-scale controlled trials.
Visualizing Space–Time Multivariate Data Consisting of Discrete and Continuous Variables: A Method for the General Public
Authors: Li Chong-En , Wu Bing-Wen , Kuo Nae-Wen , Yuan Mei-Hua
Published: January 2024

Visualizing multivariate data can be challenging, especially for the general public. The difficulties extend beyond determining how to present the data; they also involve comprehension. Early literature has identified various methods, including Chernoff’s face, but these methods often have significant drawbacks, making them challenging to interpret. Subsequently, other techniques, such as scatterplots, parallel coordinate plots, and dynamic graphics, have been introduced. However, many of these methods can be intricate to create and interpret, particularly when visualizing high-dimensional data. Additionally, simultaneously representing discrete aspects (including “space”) and continuous aspects (including “time”) presents another challenge. This study proposes a novel approach named the “Δ table” (delta table), which transforms space–time multivariate data consisting of discrete and continuous variables into a tabular format. The Δ table is believed to be more user-friendly for the general public, which is its most significant advantage compared to previous methods. Finally, we used a case study of the decoupling of the world’s developed, newly industrialized, and developing economies in recent decades as an example of an attempt to apply the Δ table.
In Vitro MRS of Cells Treated with Trastuzumab at 1.5 Tesla
Authors: Guz Wiesław , Podgórski Rafal , Bober Zuzanna , Aebisher David , Truszkiewicz Adrian , Olek Marcin , Machorowska Pieniążek Agnieszka , Kawczyk-Krupka Aleksandra , Bartusik-Aebisher Dorota
Published: January 2024

The aim of the study was to investigate the effect of Trastuzumab on the MCF-7 and CRL-2314 breast cancer cell lines. Additionally, an attempt was made to optimize magnetic resonance spectroscopy (MRS) for cell culture studies, with particular emphasis on the impact of treatment with Trastuzumab. The research materials included MCF-7 and CRL-2314 breast cancer cell lines. The study examined the response of these cell lines to treatment with Trastuzumab. The clinical magnetic resonance imaging (MRI) system, OPTIMA MR360 manufactured by GEMS, with a magnetic field induction of 1.5 T, was used. Due to the nature of the tested objects, their size and shape, it was necessary to design and manufacture additional receiving coils. They were used to image the tested cell cultures and record the spectroscopic signal. The spectra obtained by MRS were confirmed by NMR using a 300 MHz NMR Fourier 300 with the TopSpin 3.1 system from Bruker. The designed receiving coils allowed for conducting experiments with the cell lines in a satisfactory manner. These tests would not be possible using factory-delivered coils due to their parameters and the size of the test objects, whose volume did not exceed 1 mL. MRS studies revealed an increase in the metabolite at 1.9 ppm, which indicates the induction of histone acetylation. Changes in histone acetylation play a very important role in both cell development and differentiation processes. The use of Trastuzumab therapy in breast cancer cells increases the levels of acetylated histones. MRS studies and spectra obtained from the 300 MHz NMR system are consistent with the specificity inherent in both systems.
The Role of Ion-Transporting Proteins in Human Disease
Authors: Marunaka Yoshinori
Published: January 2024

This Special Issue focuses on the significance of ion-transporting proteins, such as ion channels and transporters, providing evidence for their significant contribution to bodily and cellular functions via the regulation of signal transduction and ionic environments [...]
Information Disorders in the Chilean and Spanish Press: A Comparison Using Thematic Modelling
Authors: Alcolea-Díaz Gema , Zurro-Antón Noelia , Cárcamo-Ulloa Luis
Published: January 2024

This article focuses on the role of information disorders in media coverage of cancer as a growing public health problem on both sides of the Atlantic. Taking the examples of Chile and Spain, we analysed news (n = 5522) published by major digital newspaper outlets in both countries between 2020 and 2022 to explore the elements of contextual information disorders, the over- and/or under-representation of mentions of sources and actors, and major latent topics in both journalistic systems. To achieve these objectives, we employed topic modelling and coherence techniques. The results revealed a high number of references to institutional, administrative, and political sources and actors, followed by mentions of issuers of strategic communication and, less frequently, patients’ associations. The discourses differed in their underlying topics, with risk factors and psycho-social factors being the most frequently addressed in the Spanish press and geo-political and institutional health contexts being the most frequently mentioned in the Chilean press. The topic of advances in research, however, was common in both journalistic systems. This article closes by identifying future challenges in health communication.
Polishing Mechanism of CMP 4H-SiC Crystal Substrate (0001) Si Surface Based on an Alumina (Al2O3) Abrasive
Authors: Gong Juntao , Wang Weilei , Liu Weili , Song Zhitang
Published: January 2024

Silicon carbide, a third-generation semiconductor material, is widely used in the creation of high-power devices. In this article, we systematically study the influence of three crucial parameters on the polishing rate of a silicon carbide surface using orthogonal experiments. By optimizing the parameters of chemical mechanical polishing (CMP) through experiments, we determined that the material removal rate (MRR) is 1.2 μm/h and the surface roughness (Ra) is 0.093 nm. Analysis of the relevant polishing mechanism revealed that manganese dioxide formed during the polishing process. Finally, due to the electrostatic effect of the two, MnO2 adsorbed on the Al2O3, which explains the polishing mechanism of Al2O3 in the slurry.
Origin of the 6/5/6/5 Tetracyclic Cyclopiazonic Acids
Authors: Zhang Wenyuan , Jiang Xuejian , Wang Minjun , Zhang Zhizhen , Wang Nan
Published: January 2024

The natural product α-cyclopiazonic acid (α-CPA) is a very potent Ca2+-ATPase inhibitor. The CPA family of compounds comprise over 80 chemical entities with at least five distinct skeletons. While α-CPA features a canonical 6/5/6/5/5 skeleton, the 6/5/6/5 skeleton is the most prevalent among the CPA family. However, the origin of the unique tetracyclic skeleton remains unknown. The 6/5/6/5-type CPAs may derive from a precursor of acetoacetyl-l-tryptophan (AATrp) generated from a hypothetic thioesterase-like pathway. Alternatively, cleavage of the tetramic acid ring would also result in the formation of the 6/5/6/5 scaffold. Aspergillus oryzae HMP-F28 is a marine sponge-associated filamentous fungus known to produce CPAs that act as primary neurotoxins. To elucidate the origin of this subfamily of CPAs, we performed homologous recombination and genetic engineering experiments on strain HMP-F28. Our results are supportive of the ring cleavage pathway through which the tetracyclic 6/5/6/5-type CPAs are generated from 6/5/6/5/5-type pentacyclic CPAs.
Assessment of Radiation Dosage to the Hippocampi during Treatment of Multiple Brain Metastases Using Gamma Knife Therapy
Authors: Laskowski Maciej , Błaszczyk Bartłomiej , Setlak Marcin , Kuca Maciej , Lech Arkadiusz , Kłos Kamil , Rudnik Adam
Published: January 2024

Background and Objectives: Brain metastases (BMs) pose significant clinical challenges in systemic cancer patients. They often cause symptoms related to brain compression and are typically managed with multimodal therapies, such as surgery, chemotherapy, whole brain radiotherapy (WBRT), and stereotactic radiosurgery (SRS). With modern oncology treatments prolonging survival, concerns about the neurocognitive side effects of BM treatments are growing. WBRT, though widely used for multiple BMs, has recognized neurocognitive toxicity. SRS, particularly Gamma Knife (GK) therapy, offers a minimally invasive alternative with fewer side effects, suitable for patients with a quantifiable number of metastases and better prognoses. Materials and Methods: A retrospective analysis was conducted on 94 patients with multiple BMs treated exclusively with GK at an academic medical center. Patients with prior WBRT were excluded. This study focused on the mean radiation dose received by the hippocampal area, estimated according to the ‘Hippocampal Contouring: A Contouring Atlas for RTOG 0933’ guidelines. Results: The precision of GK equipment results in mean doses of radiation that are lower than those suggested by RTOG 0933 and observed in other studies. This precision may help mitigate cognitive dysfunction and other side effects of hippocampal irradiation. Conclusions: GK therapy facilitates the administration of smaller, safer radiation doses to the hippocampi, which is advantageous even for lesions in the temporal lobe. It is feasible to treat multiple metastases, including cases with more than 10, but it is typically reserved for patients with fewer metastases, with an average of 3 in this study. This underlines GK’s potential for reducing adverse effects while managing BMs effectively.
Epidemiology and Clinical Outcomes of Fusobacterium Infections: A Six-Year Retrospective Study
Authors: Khan Akram , Alzghoul Hamza , Khan Abdul Ahad , Allada Gopal , Gronquist Juliann M. , Pak Jonathan , Mukundan Srini , Zakhary Bishoy , Wusirika Raghav , Sher Nehan , Reddy Raju
Published: January 2024

Background and Objectives: Anaerobic bacteria like Fusobacterium can lead to severe and life-threatening infections. The inherent complexities in the isolation of these bacteria may result in diagnostic and therapeutic delays, thereby escalating both morbidity and mortality rates. We aimed to examine data from patients with infections due to Fusobacterium to gain insights into the epidemiology and clinical outcomes of patients with these infections. Methods and Results: We conducted a retrospective analysis of clinical data from a cohort of patients with cultures positive for Fusobacterium species at a tertiary care medical center in the United States. Between 2009 and 2015, we identified 96 patients with cultures positive for Fusobacterium. Patients could be categorized into three groups based on the site of primary infection. Patients with head and neck infections constituted 37% (n 36). Patients with infections of other soft tissue sites accounted for 38.5% (n 37). Patients with anaerobic bacteremia due to Fusobacterium formed 24% (n 23) of the cohort. Surgical intervention coupled with antibiotic therapy emerged as cornerstones of management for patients with head and neck or other soft tissue infections, who generally exhibited more favorable outcomes. Patients with bacteremia were older, more likely to have malignancy, and had a high mortality rate. When speciation was available, Fusobacterium necrophorum was the most frequently isolated species. Conclusions: Our retrospective analysis of epidemiology and clinical outcomes of Fusobacterium infections revealed three distinct cohorts. Patients with head, neck, or soft tissue infections had better outcomes than those with bacteremia. Our findings highlight the importance of employing management strategies based on infection site and underlying comorbidities in patients with Fusobacterium infections. Further research is needed to investigate the optimal therapeutic strategies and identify prognostic indicators to improve clinical outcomes for these complex infections.
Plasma Treatment of Different Biodegradable Polymers: A Method to Enhance Wettability and Adhesion Properties for Use in Industrial Packaging
Authors: Vassallo Espedito , Pedroni Matteo , Aloisio Marco , Pietralunga Silvia Maria , Donnini Riccardo , Saitta Francesca , Fessas Dimitrios
Published: January 2024

Biodegradable polymers (poly(butylene succinate (PBS)), poly(butylene adipate terephthalate (PBAT)) and poly(lactic acid)/poly(butylene adipate terephthalate (PLA/PBAT)) blend) were treated in radiofrequency (13.56 MHz) low-pressure (10 Pa) oxygen with argon post-crosslinking plasma to enhance wettability and adhesion properties. Surface morphology and roughness modification caused by plasma exposure were observed by scanning electron microscopy (SEM) and atomic force microscopy (AFM). Surface chemical modifications of plasma-treated samples were evaluated by Fourier Transform infrared spectroscopy (FTIR). Due to the limited durability of plasma activation, the hydrophobic recovery was evaluated by water contact angle (WCA) measurements. The ageing effect was measured over 15 days in order to assess this kind of treatment as a potential industrial scalable method to increase biodegradable polymers hydrophilic properties for food packaging applications. The effects of polymer activation on its weight loss were also determined. Differential scanning calorimetry (DSC) analysis was used to study the effect of plasma treatment on the thermal properties of the polymers, while the crystallinity was investigated by X-ray diffraction (XRD).
A Low-Resolution Infrared Array for Unobtrusive Human Activity Recognition That Preserves Privacy
Authors: Newaz Nishat Tasnim , Hanada Eisuke
Published: January 2024

This research uses a low-resolution infrared array sensor to address real-time human activity recognition while prioritizing the preservation of privacy. The proposed system captures thermal pixels that are represented as a human silhouette. With camera and image processing, it is easy to detect human activity, but that reduces privacy. This work proposes a novel human activity recognition system that uses interpolation and mathematical measures that are unobtrusive and do not involve machine learning. The proposed method directly and efficiently recognizes multiple human states in a real-time environment. This work also demonstrates the accuracy of the outcomes for various scenarios using traditional ML approaches. This low-resolution IR array sensor is effective and would be useful for activity recognition in homes and healthcare centers.
Seeds: What Happened in 2023?
Authors: Hernández José Antonio , Díaz-Vivancos Pedro , Barba-Espín Gregorio
Published: January 2024

As Editor-in-Chief of Seeds, I would like to thank the Authors, Reviewers, Editorial Board Members, Academic Editors, Assistant Editors and all the Staff involved in Seeds for their effort and dedication, which has helped to establish Seeds as a scientific journal in the field of Seed Biology and Technology [...]
Engaging Young People in the Development of Innovative Nature-Inspired Technologies for Carbon Sequestration in Cities: Case Studies from Portugal
Authors: Moreira da Silva Manuela , Ferreira Lurdes , Sarmento Teresa , Selada Catarina
Published: January 2024

Currently, cities are the most vulnerable places on the planet to the effects of global change, both anthropogenic and climate-related, and this is not compatible with harmony and well-being regarding the economy, nature, and future generations. Young people have a unique potential to catalyze the transformative sustainable change that the planet needs now, as they are the first generation to grow up with tangible impacts of climate change. We tested a new strategy to empower young people to foster carbon neutrality in cities by engaging them in ecosystem services quantification and technological innovation to increase CO2 sequestration in two Portuguese cities. The species with best performance for carbon sequestration were M. exelsa in Porto and O. europea in Loulé, and for air pollutant removal and hydrological regulation were P. hispanica in Porto and P. pinea in Loulé. Through the innovative advanced summer program SLI, a nature-based learning experience, young people developed two new concepts of technological solutions to accelerate city decarbonization by designing a hedge for air pollution hotspots and a biodevice to be placed at bus stops using autochthonous shrubs and mosses. Initiatives like SLI contribute to a greater awareness among young people about the drivers that brought us to the current climate emergency, motivating them towards more balanced lifestyles and creating innovative nature-based solutions towards a smart and sustainable city.
Radiation Overuse in Intensive Care Units
Authors: Zanon Chiara , Bini Costanza , Toniolo Alessandro , Benetti Tommaso , Quaia Emilio
Published: January 2024

Radiological imaging is essential for acute patient management in Intensive Care Units (ICUs); however, it introduces the risk of exposure to ionizing radiation. This review synthesizes research on radiation exposure in ICU settings, highlighting its rise during the COVID-19 pandemic and the rise in repetitive imaging. Our analysis extends to radiation safety thresholds, revealing that some ICU patients exceed the diagnostic reference level, emphasizing the need to balance diagnostic utility against potential long-term risks, such as cancer. Prospective studies have demonstrated an increase in the median cumulative effective dose in patients with trauma over time, prompting calls for improved awareness and monitoring. Moreover, innovative dose-reduction strategies and optimized protocols, especially in neuro-ICUs, promise to mitigate these risks. This review highlights the essential but risky role of radiological imaging in critical care. It advocates for rigorous radiation management protocols to safeguard patient health while ensuring the continuity of high-quality medical care.
Patterns of Signal Intensity in CISS MRI of the Inner Ear and Eye
Authors: Mair Antonia , Song Christopher I. , Büki Bela , Ward Bryan K.
Published: January 2024

Background: Constructive interference in steady state (CISS) is a gradient echo magnetic resonance imaging (MRI) pulse sequence that provides excellent contrast between cerebrospinal fluid and adjacent structures but is prone to banding artifacts due to magnetic field inhomogeneities. We aimed to characterize artifacts in the inner ear and eye. Methods: In 30 patients (60 ears/eyes) undergoing CISS sequence MRI, nine low-signal intensity regions were identified in the inner ear and compared to temporal bone histopathology. The number and angle of bands across the eye were examined. Results: In the cochlea, all ears had regions of low signal corresponding to anatomy (modiolus (all), spiral lamina (n = 59, 98.3%), and interscalar septa (n = 50, 83.3%)). In the labyrinth, the lateral semicircular canal crista (n = 42, 70%) and utricular macula (n = 47, 78.3%) were seen. Areas of low signal in the vestibule seen in all ears may represent the walls of the membranous utricle. Zero to three banding artifacts were seen in both eyes (right: 96.7%, mean 1.5; left: 93.3%, mean 1.3). Conclusion: Low signal regions in the inner ear on CISS sequences are common and have consistent patterns; most in the inner ear represent anatomy, appearing blurred due to partial volume averaging. Banding artifacts in the eye are more variable.