bluuebunny/crossref_metadata_2025 huggingface dataset:
The Potency of Mesenchymal Stem Cells as Viral Oncolytic Carriers
Authors: Rakhman Muhammad Farid
Published: November 2024

Oncolytic viruses (OVs) represent a category of viruses that selectively replicate within tumor cells, destroying cancer cells through a dual mechanism involving viral oncolysis and the stimulation of the host's anti-tumor immune response. This selectivity ensures the virus targets and eliminates cancer cells while sparing healthy cells. Oncolytic virus immunotherapy refers to treatments utilizing either native or genetically modified OVs designed to replicate within tumor cells selectively.
Mesenchymal Stem Cells (MSCs) have demonstrated potential in facilitating the safe transportation and targeted release of oncolytic viruses at the tumor site due to their inherent tumor-specific homing capability. Utilizing MSCs as carriers for oncolytic viruses can enhance the delivery of these therapeutic agents to the tumor site, eliminating the need for direct tumor injection and reducing the associated side effects.
Stem Cell in Breast Cancer Theraphy
Authors: Kartika Juspeni , Legiran
Published: November 2024

There is a lot of research to support that cancer stem cell attract normal stem cell. The tendency of tumor cells to attract stem cells then becomes the basis for the use of stem cells in breast cancer theraphy. When neural stem cell applied as a carrier, it will make the amount, timing, and location of viral oncolytic or drug release can be precisely controlled. Finally, this situation will increase the effectiveness of breast cancer therapy and reduce side effects.
This is a brief review about potency of stem cell as breast cancer treatment. This article aim to increased our knowledge about the potency of stem cell as breast cancer treatment.
The tendency of tumor cells to attract stem cells then becomes the basis for the use of stem cells as enzyme/prodrug theraphy, secreted agent, viral oncolytic carrier or nanoparticle (drug) carrier which tends to be more localized around the tumor. When neural stem cell applied as a carrier, it will make the location, amount and timing of drug release or viral oncolytic can be precisely controlled.
Estudios de seguridad y defensa a través del análisis cuantitativo de datos
Authors: Guerrero-Sierra Hugo Fernando , Rojas-Mora Jaime Edison , Fernández-Osorio Andres Eduardo
Published: November 2024

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South African English: social and linguistic aspects
Authors: Bocharova E. A.
Published: November 2024

The research work is devoted to the analysis of the English language variability specific characteristics in the context of modern community globalization process. The research proves that the English language variant, adapting to the realities of local languages and cultures, acquires new sociolinguistic properties. The aim of the study is to identify the specifics of such a variant of the English language as the South African English which was formed during the contact interaction of the British English language and the autochthonous languages and cultures of South Africa. The key properties of the South African English are revealed on the basis of methods groups: analysis and synthesis; comparative analysis; and the method of component analysis. The key attention is paid to the historical process formation of South African English and to the development of the English language and its role in the life of South Africa. The complex nature of long-term historical inter language and intercultural interaction has led to the formation of a heterogeneous structure of South African society, is which is presented by Europeans, numerous local peoples, Indians and their descendants living on the same territory. The complex differentiation of South African society has defined a unique variety of languages, dialects, and sociolects, among which English has a special social prestige and unites all other languages. Having a multicomponent structure, sociolinguistic differentiation of South African society contributed to the emergence and functioning a series of South African English variants types in one territory. These types are: Black South African English, White South African English, Coloured South African English. The English language of each sociolinguistic group has unique features that manifest themselves to a greater extent at the phonetic level.
Strategies of Direct and Indirect Verbal Expression of Negative Evaluation in Russian and Vietnamese Political Discourse
Authors: Nguyet Nguyen Thi Minh
Published: November 2024

The article examines strategies and tactics of verbal expression of negative evaluation frequently used in Russian and Vietnamese political discourse. The relevance of this research is underlined by the significant role of political discourse in societal and individual life, the lack of studies exploring pragmalinguistic aspects of Vietnamese political discourse, and the absence of comparative analysis of Russian and Vietnamese political discourse. The purpose of this work is to investigate the strategies and tactics of verbal expression of negative evaluation in Russian and Vietnamese political discourse, to delve into the tactics of implementing the main strategies, to identify similarities and differences in their application, and to explain the latter through politeness theory. The study is conducted on the material of parliamentary communication of the National Assembly of the Socialist Republic of Vietnam and the Federation Council of the Federal Assembly of the Russian Federation. Methods used include descriptive, comparative, classification, functional-pragmatic methods, as well as content analysis. The findings show that Russian and Vietnamese politicians employ two basic strategies – direct and indirect expression of negative evaluation, along two auxiliary strategies of mitigation and intensification. Each strategy has a set of tactics, frequency of application of which differs between the two political discourses, but still generally adhere to norms of institutional political communication and the principle of politeness. Thus, the use and combination of various strategies and tactics of expressing negative evaluation in Russian and Vietnamese political discourse not only serve to express the speaker’s negative attitude towards the object of evaluation and to influence the listener’s attitude towards this object, but also contribute to fulfilling parliamentary functions and maintaining communicators’ “face”.
Publication Counts in Context: Normalization Using Query and Reference Terms in PubMed
Authors: Varghese Julian , Bickmann Lucas , Strünker Timo , Neuhaus Nina , Tüttelmann Frank , Sandmann Sarah
Published: November 2024

This article discusses the extensive use of publication counts as indicators of trends in the scientific activities of individual researchers, research groups, and entire disciplines. However, with the growing number of articles in general, these counts might produce false impressions among scientists. We propose a straightforward yet effective normalization method, which enables further context of publication counts by using a query and a reference term. Additionally, an open access implementation is readily available on the PubMed Normalization website.
ВЛИЯНИЕ ПЛАСТИЧЕСКОЙ ДЕФОРМАЦИИ НА СТРУКТУРУ И СВОЙСТВА БИОРЕЗОРБИРУЕМОГО ЦИНКОВОГО СПЛАВА Zn-0.8Li-0.1Mn
Authors: Сиразеева А.Р. , Хасанова А.Р. , Кулясова О.Б. , Аксенов Д.А. , Большаков Б.О.
Published: November 2024

В данной работе представлены результаты исследования влияния пластической деформации на структуру и свойства цинкового сплава Zn-0.8Li-0.1Mn. Эволюция структуры охарактеризована методами растровой электронной микроскопии (РЭМ) и EBSD. Обсуждаются диаграммы "напряжение – относительное удлинение", полученные при одноосном растяжении.
Influence of Vitamin D Status and the VDR Gene Polymorphism on COVID-19 Susceptibility and Outcome
Authors: Mohamed Amal Ahmed , Baiomy Nivin Naeem , Rawy Abeer M. , Ghanem Mona M.F. , Abd El Salam Soha M. , Nasraldin Karima , Ezz Al Arab Mohamed Ramadan , Samir Hussein H. , Azzam Omar Mohamoud , Muharram Nashwa M. , Elsalway Naglaa , Elamir Ahmed Y. , Swed Sarya , Hafez Wael , Salas-Matta Luis A. , Rodriguez-Morales Alfonso J. , Bonilla-Aldana D. Katterine , Abu Serhan Hashem , Sah Sanjit , Mehta Rachana
Published: November 2024

Insufficient vitamin D levels in the bloodstream, together with the presence of specific genetic variations known as single nucleotide polymorphisms (SNPs) within the VDR gene, have consistently been linked to a higher likelihood of contracting and experiencing more severe forms of various diseases such as the ongoing COVID-19 pandemic. We aimed to explore the potential relationship between vitamin D levels, Bsml and FOKI polymorphisms, and COVID-19 infection outcomes. A case-control study was conducted with COVID-19 patients and a control group of non-COVID-19 patients (n = 107 each). The associations between vitamin D status, polymorphisms, and COVID susceptibility were investigated. Participants diagnosed with COVID-19 exhibited an average age of 48.84 ± 12.18, while non-COVID-19 patients had an average age of 46.82 ± 9.903. Disease severity, assessed by the CT severity score, showed a negative correlation with the Vitamin D levels. Among participants with COVID-19, the mean level of vitamin D was 35.25 ± 9.40 ng/mL while non-COVID-19 patients showed 38.85 ± 9.40 ng/mL with a significant difference (p = 0.004**) although among COVID-19 cases, 87 (81.3%) individuals had sufficient vitamin D levels and non-severity of disease was more common i.e. 54 (50.5%) among the COVID patients who had sufficient level of Vitamin D. The study found no significant association between Vitamin D levels and rs1544410 Bsml polymorphism (p = 0.429). However, it is important to highlight a weak significant association observed between with Fok1 polymorphism (p = 0.049). These findings underscore the weak influence of genetic factors, particularly VDR Fok1 gene variants, in shaping an individual’s susceptibility to COVID-19. A significant difference in vitamin D status was observed between the COVID-19 and non-COVID-19 groups and lower level was observed in the COVID-19 infected patients. Furthermore, a weak significant association was observed between Fok1 rs2228570 genotype and COVID-19 susceptibility. Larger sample sizes are required to comprehensively understand the association between different genotypes and COVID-19 outcomes.
In vitro Production and Characterization of a Recombinant Viral Protein (rVP1) of Coxsackievirus B3 (CVB3): Contribution for the Development of a Subunit Vaccine or an Immunodiagnostic Reagent
Authors: Alyami Ameera , Hassine Ikbel Hadj , Gharbi Jawhar , M’hadheb Manel Ben
Published: November 2024

Coxsackievirus B3 is an Enterovirus implicated in diverse human pathologies, from viral myocarditis to neurological disorders. There isn’t a medicinal agent or vaccine for CVB3 in clinical use at the moment, despite the possibility that vaccination could lower the prevalence of these illnesses. This study focuses on the in vitro production and characterization of the viral protein 1 (VP1) in the objective to use it as subunit vaccine and/or immunodiagnostic reagent. VP1 is considered as the most immunogenic capsid protein of the CVB3 surface. We amplified the VP1 whole gene by RT-PCR from the extracted wild type Nancy strain RNA, then cloned it into the pUC19 plasmid expression vector, and expressed it in E. coli DH5a prokaryotic cells. The obtained recombinant proteins were then analyzed by SDS-PAGE and characterized by Bioinformatic software tools. Our results revealed that the produced recombinant amino acid VP1 (rVP1) is highly identical to the VP1 of the CVB3 wild-type strain and has very similar physicochemical properties. In addition, we demonstrated that rVP1 has the highest number of phosphorylation sites which means that rVP1 can translate the host cell signal via the phosphorylation mechanism. Moreover, The Linear B cell epitope analysis showed that the rVP1 contains many epitope regions that should be recognized by the humoral host immune response. Taken together, results demonstrate that the cloned and recombined expressed viral protein could be used to carry out any studies concerning the development a protein subunit vaccine against CVB3 infections or an immunodiagnostic reagent for detecting the virus in samples.
Autonomous Street Lighting System based on Solar Energy and LEDs
Authors: Shevade Sahil D.
Published: November 2024

This paper introduces a solar-powered autonomous street lighting system designed primarily for areas without access
to the grid, such as rural roads and intersections. It utilizes solar panels as the primary energy source, with batteries serving as
backup, and employs light-emitting diodes (LEDs) for illumination. The proposed system is optimized for efficiency by employing
direct current (DC) power at all stages. To replace a 70W high-pressure sodium (HPS) lamp, an LED fixture design is discussed,
considering human scotopic vision. Experimental outcomes for the LED driver and battery charger are provided, demonstrating
features such as maximum power point tracking (MPPT), constant current, and constant voltage modes. The system ensures
MPPT under varying solar irradiance and temperature conditions by analyzing the battery charger input impedance.
Smoking Behaviour, Knowledge, Attitude, and Practice among Students of University of Aseer Region at KSA
Authors: Amalanathan Selvia Arokiya Mary
Published: November 2024

Background: Tobacco smoking remains a major global public health challenge, contributing significantly to
respiratory, cardiovascular, and neoplastic diseases. (9)In Saudi Arabia, smoking rates among college students are of particular
concern, reflecting a growing need for targeted interventions.(10)
Objective: This study aimed to assess the knowledge, attitudes, and practices regarding cigarette smoking among college students
at the University of Bisha, Aseer region, to better understand smoking behavior and inform public health strategies.(12)
Methods: A cross-sectional descriptive study was conducted using a self-administered questionnaire based on the Global Adult
Tobacco Survey (GATS). (18) The study included 100 college students who were surveyed about their smoking status,
knowledge, attitudes, and practices related to smoking. Data were analyzed using IBM SPSS software, version 24, with chisquare tests employed for statistical significance (p < 0.05).
Results: Among the 100 participants, 66.4% were never smokers, 23.6% were current smokers, and 10.0% were ex-smokers. The
study found that male students were significantly more likely to be current or ex-smokers compared to female students. (16)
Increased education level correlated with a decrease in smoking prevalence.(15) Knowledge levels about smoking's effects and
attitudes towards smoking differed significantly between never smokers, current smokers, and ex-smokers. (19)The majority of
never smokers and ex-smokers cited health concerns as their primary reason for avoiding or quitting smoking, while current
smokers predominantly viewed smoking as a stress reliever.(14) Only 49.2% of current smokers consistently declared their
smoking status to healthcare providers, and 61.0% received advice to quit.(11)
Discussion: The study highlights a significant disparity in smoking prevalence and attitudes between genders and across
education levels. The results suggest that enhanced awareness and educational interventions are needed, especially targeting
current smokers and integrating effective cessation methods such as counseling and nicotine replacement therapy.(17)
Conclusion: This study underscores the importance of improving knowledge and attitudes toward smoking to reduce smoking
rates among college students. Early intervention, increased access to cessation resources, and targeted health education can play
crucial roles in addressing smoking behaviors in this population.(13)
Beyond MP2 initialization for unitary coupled cluster quantum circuits
Authors: Hirsbrunner Mark R. , Chamaki Diana , Mullinax J. Wayne , Tubman Norm M.
Published: November 2024

The unitary coupled cluster (UCC) ansatz is a promising tool for achieving high-precision results using the variational quantum eigensolver (VQE) algorithm in the NISQ era. However, results on quantum hardware are thus far very limited and simulations have only accessed small system sizes. We advance the state of the art of UCC simulations by utilizing an efficient sparse wavefunction circuit solver and studying systems up to 64 qubits. Here we report results obtained using this solver that demonstrate the power of the UCC ansatz and address pressing questions about optimal initial parameterizations and circuit construction, among others. Our approach enables meaningful benchmarking of the UCC ansatz, a crucial step in assessing the utility of VQE for achieving quantum advantage.
EL ROL DE LA MATRONERÍA EN EL MANEJO DE PESARIO: UNA PRÁCTICA PARA REFLEXIONAR
Authors: Hernández-Escobar Alejandro , Aguilar-García Francisca
Published: November 2024

Los pesarios son dispositivos de material plástico o silicón que se introducen por vía vaginal y funcionan como soporte u ocupadores de espacio para evitar el Prolapso de Órganos Pélvicos, siendo el tratamiento de primera línea para usuarias que presentan signos y/o síntomas de prolapso genital y/o Incontinencia de Orina que no pueden optar o no desean un tratamiento quirúrgico. Actualmente la indicación del uso de pesario es por profesional médico Uro-ginecólogo; sin embargo, el manejo de este dispositivo podría ser parte del rol de Matronería. En este sentido, la Matrona o Matrón presenta todas las competencias para poder realizar un examen ginecológico, lo que hace que sea un profesional idóneo para el manejo del pesario. En Chile varios hospitales cuentan con la unidad de Piso Pélvico. No obstante, se evidencia un vacío en el rol de Matronería en el manejo del pesario, por lo que se plantea la necesidad de destacar este control de salud uro-ginecológica tan importante para aquellas mujeres que vivencian una disfunción de su Piso Pélvico. Es por lo anterior, que a continuación se efectúa una reflexión para fundamentar a través de la literatura la importancia del rol de la Matronería en el manejo del pesario.
ANÁLISIS DE LA INCORPORACIÓN DE LA VACUNA NONAVALENTE ANTI-VIRUS PAPILOMA HUMANO EN CHILE
Authors: Ibarra-Pérez Andrés
Published: November 2024

Las vacunas anti-Virus Papiloma Humano (VPH) constituyen hoy en día la principal herramienta para el control del cáncer de cuello uterino, ya que previenen la infección de este virus, identificado como el agente etiológico de esta patología. El Programa Nacional de Inmunizaciones ha incorporado, a partir del presente año, la vacuna nonavalente anti-Virus Papiloma Humano para la prevención del cáncer de cuello uterino lo que constituye una acertada decisión sanitaria. La vacuna nonavalente anti-VPH tiene el potencial de prevenir la infección de nueve subtipos virales, dos de bajo riesgo (6 y 11), asociados a lesiones benignas, y siete de alto riesgo (16, 18, 31, 33, 45, 52 y 58) relacionados con el noventa por ciento de todos los cánceres de cuello uterino. La vacuna nonavalente anti-VPH viene a sustituir a la vacuna tetravalente, vigente en Chile desde 2014, la cual solo previene la infección de los subtipos 6, 11, 16 y 18. Es decir, su alcance o protección es menor en relación a la vacuna nonavalente.
Análise das taxas de sedimentação do rio Jacuí entre Vale Verde e São Jerônimo - Bacia hidrográfica do Baixo Jacuí (Rio Grande do Sul, Brasil)
Authors: Moreira Igor Sieczkowski , Vicente Goulart Rossana , Mainardi Fan Fernando
Published: November 2024

Este trabalho objetiva comparar metodologias para a investigação do transporte de sedimentos no rio Jacuí, e assim apontar qual melhor se aplica enquanto ferramenta de gestão ambiental. Para tal, foram calculadas as taxas de sedimentação por três métodos: descarga de sólidos, diferença de cubagens e modelagem hidrossedimentológica. No primeiro, as taxas de sedimentação foram obtidas pela diferença de transporte de sedimentos entre seções. No segundo, foram calculadas para diferentes trechos de extração mineral por meio da diferença de volumes de sedimentos. Por fim, foi realizado o modelamento computacional de sedimentos do trecho entre Vale Verde e Amarópolis para o período de 2012 a 2019, o qual indicou predominância de sedimentação na região. Os primeiros métodos foram comparados qualitativamente com o modelo. Concluiu-se que o método da diferença de cubagens é a ferramenta mais adequada, simples e eficaz o objetivo proposto.
Práticas corporais na Amazônia
Authors: Mota Ieda Oliveira , Genú Soares Marta
Published: November 2024

O processo de escolarização brasileiro, alicerçado pelo prisma da modernidade, fortaleceu no cotidiano escolar a predominância de práticas pedagógicas homogêneas e monoculturais que não dialogam com a diversidade cultural presente na escola. Argumentamos que esse cenário traz implicações para o processo educativo e para a formação do sujeito, além de provocar tensões ou conformidade diante da (in)adequação frente à cultura dominante. Diante disso, o presente artigo analisa as interseções entre cultura, escola e práticas corporais desenvolvidas na Amazônia para a valorização dos sujeitos e significação do processo de aprendizagens à luz da interculturalidade crítica e da educação física cultural. O diálogo com o campo teórico opõe-se aos modelos vigentes de pensar e construir a educação e tensiona em favor do reconhecimento dos diferentes conhecimentos, da valorização e do respeito à diversidade de sujeitos e culturas para a construção de uma sociedade mais democrática, plural e humana.
Valoração da atividade física
Authors: Andalécio Couto da Silva Ana Flávia , Bosquiero Papini Camila , Sebastião Emerson , Brunheroti Karina , Christian Ribeiro Andaki Alynne , Kokubun Eduardo
Published: November 2024

A valoração da atividade física é uma abordagem não evidenciada como conceito ou definição. Assim, o objetivo do presente estudo foi compreender a conceituação e fomentar uma discussão preliminar acerca da valoração da atividade física, por meio de uma revisão sistemática de literatura seguida de uma revisão integrativa utilizando diferentes estratégias de busca. A partir dos critérios de inclusão da revisão sistemática não foram identificados estudos que procuraram definir e/ou conceituar a valoração da atividade física. Porém, a partir da seleção e leitura dos artigos na revisão integrativa, buscou-se compreender em quais contextos os estudos foram desenvolvidos e quais os métodos de valoração se referiam à atividade física. Sugere-se que a valoração da atividade diz respeito à importância que o indivíduo direciona a atividade física, ou seja, um juízo de valor determinado à atividade física que pode se relacionar ao custo hedônico, valoração contingente e ao custo evitado.
perspectiva teórica bourdieusiana na análise do comitê paralímpico brasileiro no interior do esporte paralímpico do Brasil
Authors: Lutiano Valerio Danilo , Ferreira de Araújo Paulo , Bettine de Almeida Marco Antônio
Published: November 2024

Utilizando como referencial teórico as Categorias de Campo, Capital e Habitus, o artigo tem como objetivo analisar se a institucionalização do Comitê Paralímpico Brasileiro foi determinante para o desenvolvimento esportivo paralímpico do Brasil. O estudo se configura como uma pesquisa qualitativa, tendo sua coleta de dados realizada a partir de entrevistas semiestruturadas com seis sujeitos (três atletas paralímpicos e três dirigentes esportivos paralímpicos). A institucionalização do Comitê Paralímpico Brasileiro foi fator fundamental para o desenvolvimento esportivo paralímpico do Brasil, dado que essa Entidade esportiva se tornou o coordenador central que sistematizou e efetuou um planejamento estratégico de caráter profissional, ancorado em três eixos (Governamental – Diretiva – Esportiva) que tiveram como princípios fundamentais o foco em práticas Organizacionais/Administrativas – Financeiras – Em Infraestrutura – Técnicas/Físicas/Esportivas. Essa sistematização estrutural fomentou a implementação de projetos e programas de prática esportiva paralímpica com o objetivo principal de formar e desenvolver atletas paralímpicos de rendimento.
Mujeres en pedagogía en Educación Física
Authors: Matus-Castillo Carlos , Rodríguez Mery , Contreras Johana
Published: November 2024

La literatura ha destacado la masculinización de la carrera de Pedagogía en Educación Física (PEF). En este estudio, se buscó comprender desde la perspectiva de género las dificultades en las experiencias formativas de las estudiantes de PEF en el contexto de una carrera masculinizada. Adoptando un enfoque cualitativo dentro del paradigma interpretativo, se llevaron a cabo seis grupos focales con un total de 20 estudiantes mujeres de seis universidades chilenas en los cuales se utilizó un guión semiestructurado. Los datos recopilados se analizaron temáticamente para identificar temas recurrentes y variaciones en las respuestas. Se realizaron interpretaciones para buscar relaciones y significados subyacentes. Tres hallazgos relevantes surgieron: a) una baja conciencia sobre la presencia de la masculinización en la carrera; b) la persistencia de sexismo y estereotipos de género, a los cuales las estudiantes reaccionaron mediante justificación, resignación y cuestionamiento; y c) una división y, a veces, jerarquización entre el deporte y la pedagogía en términos de género.
An Optimized Box-Behnken Design RP-HPLC Method For The Quantification Of Umiclinidinium Bromide And Vilanterol Trifenate In Oral Inhalation
Authors: TATAPUDI HEMANT KUMAR , Bairam Ravinder , Kassireddy Vanaja , Mohammed Rukkiya Jabeen , Baithi Ankitha , Yata Sowmya
Published: November 2024

A liquid chromatographic method with enhanced efficacy has been proposed for the simultaneous quantification of Vilanterol Trifenate and Umiclinidinium Bromide in pharmaceutical formulation. This method is straightforward, sensitive, accurate, precise, and dependable. The RP-HPLC method's experimental parameters were multivariately optimized using the design of experiments (DoE). Mathematical models were created using three independent variables: the percentage of acetonitrile, the strength of the buffer, and the pH of the mobile phase.   In order to examine the response surface methodology and the effects of these independent factors, a box-behnken design (BBD) was utilized.   The optimized and forecasted data from the contour diagram utilized a mixture of acetonitrile (58.6% v/v) and phosphate buffer (12.6 mM) with a pH of 5.1. The flow rate was adjusted to 1 milliliter per minute and the analytical wavelength employed was 272 nm.   The pharmaceuticals were successfully separated with high resolution in less than 6 minutes under ideal conditions, and the validation process was conducted in accordance with the requirements set by the International Council for Harmonisation (ICH).   The findings indicated that the Quality by Design technique was effective in optimizing the RP-HPLC method for quantifying Vilanterol Trifenate and Umiclinidinium Bromide.
Assessing Patient Risk, Benefit, and Outcomes in Drug Development: A Decade of Abiraterone Clinical Trials
Authors: Rashid Matthew , Oldham Eli , Hughes Griffin K. , Peña Andriana M. , Ladd Chase , Gardner Brooke , McIntire Ryan , Johnson Bradley , Tuia Jordan , Haslam Alyson , Prasad Vinay , Vassar Matt
Published: November 2024

Purpose: Our study aimed to evaluate the risk and benefit profiles of clinical trials using abiraterone in cancer treatment.Materials and Methods: A comprehensive search was conducted on May 24, 2023, using databases such as PubMed, Embase, Cochrane CENTRAL, and ClinicalTrials.gov. We extracted data on adverse events, progression-free survival, overall survival, objective response rate (ORR), and prostate-specific antigen response rate (PSA-RR). The Common Terminology Criteria for Adverse Events were used to assess risks, while ORR and PSA-RR were used to assess benefits. Trials were categorized as positive, negative, or indeterminate based on their safety profiles and efficacy outcomes.Results: Nearly all clinical trials testing abiraterone in prostate cancer showed promising outcomes with 89% of studies meeting their endpoint. Our study supports abiraterone’s use in prostate cancer, its only U.S. Food and Drug Administration-approved indication to treat, with a median ORR of 20.0% and a median PSA-RR of 42.0%. However, when looking at the 3 novel indications tested, the risk-to-benefit profile was similar to that of its original approval. Even though most novel indications failed to meet their primary endpoint, the overall toxicity profile was similar to that found in prostate cancer.Conclusion: Abiraterone showed an overall risk-to-benefit portfolio that supports the use of its treatment in prostate cancer. Although the primary endpoints in ovarian and breast cancer trials were not met, the use was appropriate when assessing how the mechanism of action for abiraterone could be beneficial in patients with these types of cancers.
Trimodal Therapy in the Treatment of Muscle-Invasive Bladder Cancer
Authors: Jo Yongsoo , Yuk Hyeong Dong
Published: November 2024

This review examines the evolution, clinical efficacy, and future directions of trimodal therapy (TMT) as a bladder-preserving treatment option for muscle-invasive bladder cancer. A nonsystematic literature search was conducted on PubMed in October 2024 using the following keywords: “muscle invasive bladder cancer,” “bladder preservation,” “trimodal therapy,” “chemoradiotherapy,” and “radiation therapy.” Papers published between 2000 and 2024 were included, and original articles, reviews, and editorials written in English were selected. Relevant studies were organized and cited in the analysis. TMT, which consists of transurethral resection of the bladder tumor, chemotherapy, and radiotherapy, demonstrated comparable oncologic outcomes to radical cystectomy (RC) in terms of 5-year overall survival (36%–74%) and cancer-specific survival (50%–82%). Long-term data from multiple studies indicate that TMT can preserve bladder function while maintaining acceptable survival rates. The recent integration of immune checkpoint inhibitors with TMT shows promise, further improving tumor control and expanding the eligible patient population. However, standardized protocols and long-term follow-up data are still lacking. TMT serves as an effective alternative to RC in selected patients, offering similar oncologic outcomes while preserving quality of life. Further research is needed to establish standardized protocols and to refine patient selection criteria to optimize treatment outcomes.
Energetic properties of the (fast) charging and driving of an electric vehicle - a Ragone analysis
Authors: Rufer Alfred
Published: November 2024

The energy efficiency of EVs is analysed for the charging and for the driving
process where real parameters of a product of the automotive industry are
considered. The efficiency in the charging mode is analysed and represented
in function of the charging time. The maximum charging power allowed by the
manufacturer is defining the lowest efficiency. After the calculation in a
situation with an ideal charging station the influence of the resistance of
the charging cable is taken into consideration. For the driving mode, the
efficiency is estimated with the help of a special tool called ?The Theory
of Ragone plots?. The driving efficiency is calculated for the maximum
possible propulsion power of the car, and represented in a dimensionless
Ragone representation. The rated power of the car is represented in
reference to the maximum possible power that can deliver the car battery.
Comparison of the performance of artificial neural network with variable step-size adaptive algorithms for the beamforming of smart antenna for cellular networks
Authors: Samantaray Barsa , Das Kumar , Roy Jibendu
Published: November 2024

A smart antenna is an antenna array that uses spatial diversity to identify
the desired mobile station (MS) and reject the unwanted interference signal
in a cellular network. Generally, adaptive signal processing algorithms are
used for smart antenna beamforming, and one of the most common algorithms is
the least mean square (LMS) algorithm. Here, the artificial neural network
(ANN) is used for beamforming of smart antennas, and the performance of the
ANN is compared with the performance of variable step-size LMS (VS-LMS) and
variable step-size sign LMS (VS-SLMS) algorithms. The ANN has better
performance than the VS-LMS and VS-SLMS algorithms for the determination of
user and null directions. Lower side lobe levels (SLLs) are achieved using
ANN compared to the VS-LMS and VS-SLMS algorithms. The reduction of SLL from
about 3.5 dB to 8.5 dB is achieved using ANN compared to signal processing
algorithms.
La sostenibilidad empresarial como motor de competitividad económica: El papel estratégico de la comunicación
Authors:   Universidad Estatal Amazónica, Cueva Villamarín Andrea , Troya Villares Bryan ,   Universidad Estatal Amazónica, Montero Mora María ,   Universidad Estatal Amazónica
Published: November 2024

El presente documento analiza cómo la sostenibilidad empresarial puede convertirse en un factor clave para la competitividad económica en mercados globales. Se justifica en la creciente necesidad de que las empresas adopten prácticas sostenibles para minimizar su impacto ambiental y social, dado que esto les permite mejorar su imagen de marca, atraer inversiones, y fomentar la innovación. El objetivo principal es evaluar cómo la comunicación estratégica juega un papel fundamental en maximizar el valor económico de estas prácticas, destacando su importancia como herramienta clave para atraer clientes, inversores y otros stakeholders. La metodología se basa en un enfoque cualitativo que abarca un análisis descriptivo sobre la relación entre sostenibilidad, competitividad y comunicación. Entre los resultados relevantes, se destaca el papel central que tiene la comunicación en fortalecer la imagen de marca y en influir en la toma de decisiones de los consumidores y por ende posicionarse mejor en los mercados, lo que contribuye directamente a su competitividad. La discusión señala que, aunque algunas empresas recurren al “greenwashing”, la sostenibilidad auténtica puede generar beneficios tangibles a largo plazo. En conclusión, se determina que la integración de prácticas empresariales sostenibles, junto con una gestión efectiva de la comunicación, se establece como un motor para la competitividad económica a largo plazo, beneficiando tanto a las empresas, a fin de mejorar sus índices de competitividad y crecimiento empresarial, como a la sociedad en su conjunto.
El rol del Inglés en la enseñanza de la Electrónica mediante el uso de tecnologías de aprendizaje y conocimiento TAC
Authors:   Universidad Estatal de Milagro Ecuador, Valle Oñate Paulina Sofía , Maldonado León Ana Elizabeth ,   Universidad Nacional de Chimborazo Ecuador, Chávez Guzmán Diana Carolina ,   Universidad Nacional de Chimborazo, Ecuador., Inca Guerrero Jhon Jairo ,   Universidad Nacional de Chimborazo, Ecuador.
Published: November 2024

La fusión del inglés técnico y las Tecnologías de Aprendizaje y Conocimiento (TAC) en la enseñanza electrónica ha sido constituida como una herramienta transformadora para la comprensión técnica, el rendimiento académico y para la preparación de los alumnos respecto al mercado laboral globalizado; gracias a que, además del desarrollo de competencias lingüísticas y técnicas, también desarrollan competencias transversales como la creatividad, la resolución de problemas y la colaboración global, las cuales son esenciales en un entorno profesional competitivo. Mientras que, en países como India, Estados Unidos y China se ha podido observar un liderazgo en su puesta en práctica, en América Latina lo que se ha evidenciado es la adopción de la TAC correspondiente a los avances que han estado marcando Brasil, México y Ecuador, aun cuando ha demostrado con ello también que se pueden adaptar sus primeras experiencias en la ejecución conforme a sus contextos, continuando con la Una apertura a la inclusión educativa. Aun así, en la situación presentan ciertas dificultades como la falta de infraestructura, las brechas en la formación de los educadores o las desigualdades que se muestran en el acceso a recursos, específicamente en países en según desarrollo. Al mismo tiempo, esto ha permitido dar cuenta que se requieren políticas educativas que traten de reducir aquellas brechas, que favorezcan la igualdad y que fortalezcan la misma formación de los docentes, ya que la configuración del inglés técnico y la TAC supondrían ser aquellas estrategias que fomenten la formación de profesionales inclusivos, competentes y bien preparados para los retos del futuro.
O SISTEMA INTERAMERICANO DE DIREITOS HUMANOS E SUA INTERSEÇÃO COM POLÍTICAS PÚBLICAS NA EFETIVAÇÃO DOS DIREITOS HUMANOS NA AMÉRICA LATINA
Authors: Farias Mariana Lima
Published: November 2024

Este artigo propõe a discussão sobre a relevância do Sistema Interamericano de Direitos Humanos (SIDH) para a efetivação dos direitos humanos fundamentais na América Latina. O SIDH desempenha um papel crucial na promoção das políticas públicas de acesso à justiça e na defesa dos direitos sociais, contribuindo para o fortalecimento da participação direta da sociedade civil na luta pelos direitos humanos na região. Com isso, o objetivo deste ensaio consiste em destacar como o SIDH tem influenciado diretamente na implementação e efetivação dos direitos humanos, fornecendo recursos e orientações para os Estados membros. Por meio de sua atuação, o SIDH tem garantido o acesso à justiça para grupos marginalizados e tem promovido a participação ativa da sociedade civil na formulação e implementação de políticas públicas voltadas para a proteção dos direitos humanos. Em conclusão, é fundamental reconhecer a importância do SIDH na efetivação dos direitos humanos fundamentais na América Latina. O fortalecimento das relações entre o SIDH e as políticas públicas é essencial para promover uma democracia participativa e garantir a proteção dos direitos humanos em toda a região.
PENGARUH KEPEMIMPINAN TRANSFORMASIONAL TERHADAP KEUNGGULAN BERSAING DENGAN PERILAKU INOVATIF SEBAGAI VARIABEL MEDIASI
Authors: Adrianisya Aqifa , Ribhan Ribhan , Nabila Nuzul Inas
Published: November 2024

The high number of competitors gives Micro, Small and Medium Enterprises (MSMEs) Sentra Keripik Pisang on Jalan PU Bandarlampung a competitive advantage, making it superior to similar business competitors. It requires transformational leadership that can encourage and facilitate innovation so that companies can survive in a highly competitive environment.  This research aims to determine the impact of transformational leadership on competitive advantage and whether innovative behaviour mediates the impact of transformational leadership on competitive advantage. This type of research is quantitative, and the primary data was obtained by distributing questionnaires. The number of research samples was calculated according to Slovin’s formula, resulting in 130 respondents who were members or employees of the Sentra Keripik Pisang MSMEs on Jalan PU Bandar Lampung. Research data analysis using Structural Equation Modeling (SEM) was conducted using IBM SPSS AMOS 23 software. The results obtained from the research show a p-value> 0.05, so transformational leadership does not significantly impact competitive advantage. Furthermore, innovative behaviour completely mediates the impact of transformational leadership on competitive advantage with a significant value of the Sobel test of 2.811 or > 1.96 and p-value <0.05.
Keywords: Transformational Leadership, Innovative Behavior, Competitive Advantage
Abstrak
Sentra Keripik Pisang di Jalan PU Bandarlampung menghadapi banyak pesaing, sehingga diperlukan keunggulan kompetitif untuk lebih menonjol dibandingkan usaha sejenis. Dalam hal ini, kepemimpinan transformasional berperan penting dalam mendorong dan memfasilitasi inovasi agar perusahaan dapat bertahan di lingkungan bisnis yang sangat kompetitif. Penelitian ini bertujuan untuk menganalisis pengaruh kepemimpinan transformasional terhadap keunggulan bersaing, serta mengevaluasi peran mediasi perilaku inovatif dalam hubungan tersebut.
Penelitian ini menggunakan metode kuantitatif dengan data primer yang diperoleh melalui kuesioner. Sampel penelitian, sebanyak 130 responden yang merupakan anggota atau karyawan UMKM Keripik Pisang di Jalan PU Bandarlampung, ditentukan menggunakan rumus Slovin. Analisis data dilakukan dengan menggunakan Structural Equation Modeling (SEM) melalui perangkat lunak IBM SPSS AMOS 23.
Hasil penelitian menunjukkan bahwa nilai p-value > 0,05, yang mengindikasikan bahwa kepemimpinan transformasional tidak memiliki pengaruh signifikan secara langsung terhadap keunggulan bersaing. Namun demikian, perilaku inovatif sepenuhnya memediasi hubungan tersebut, dengan nilai signifikansi uji Sobel sebesar 2,811 (lebih besar dari 1,96) dan p-value < 0,05.
Kata Kunci: Kepemimpinan Transformasional, Perilaku Inovatif, Keunggulan Bersaing
THE IMPACT OF ARTIFICIAL INTELLIGENCE AND REGULATORY STRATEGIES ON THE ECONOMICS: LEARNING FROM INDONESIA, CHINA, AND EUROPE
Authors: Winardi Bella Thalia , Halim Evelyne Julian
Published: November 2024

This study examines the economic impact of artificial intelligence (AI) on labor markets and regulatory strategies in Indonesia, China, and Europe. Through a literature review, it assesses how AI adoption influences productivity, job creation, and displacement in these regions. Indonesia faces challenges like infrastructural and educational gaps, though targeted investments and reskilling could boost growth and mitigate job losses. Meanwhile, China and Europe benefit from AI-driven productivity but also confront labor market disruptions, requiring strong policy responses. Indonesia focuses on foundational AI integration, while China pursues aggressive technological advancement and regulation. Europe prioritizes ethical AI use, data protection, and workforce resilience through education and retraining. The study highlights the importance of region-specific regulatory frameworks and calls for continued international collaboration to address global AI-related labor issues. Cross-regional knowledge exchange is crucial for managing labor market transitions and ensuring AI's benefits  are widely shared.
Keywords:  Artificial Intelligence (AI); Labor Market Disruption; Regulatory Frameworks
Abstrak
Studi ini meneliti dampak ekonomi kecerdasan buatan (AI) terhadap pasar tenaga kerja dan strategi regulasi di Indonesia, Tiongkok, dan Eropa. Melalui tinjauan literatur, studi ini mengevaluasi bagaimana adopsi AI memengaruhi produktivitas, penciptaan lapangan kerja, dan pengurangan tenaga kerja di wilayah-wilayah tersebut. Indonesia menghadapi tantangan seperti kesenjangan infrastruktur dan pendidikan, meskipun investasi yang ditargetkan dan peningkatan keterampilan dapat mendorong pertumbuhan dan mengurangi kehilangan pekerjaan. Sementara itu, Tiongkok dan Eropa memperoleh manfaat dari produktivitas yang didorong oleh AI, tetapi juga menghadapi gangguan pasar tenaga kerja, yang membutuhkan respons kebijakan yang kuat. Indonesia berfokus pada integrasi AI dasar, sedangkan Tiongkok mengejar kemajuan teknologi dan regulasi secara agresif. Eropa memprioritaskan penggunaan AI yang etis, perlindungan data, serta ketahanan tenaga kerja melalui pendidikan dan pelatihan ulang. Studi ini menekankan pentingnya kerangka regulasi spesifik untuk setiap wilayah dan menyerukan kerjasama internasional yang berkelanjutan untuk mengatasi isu-isu tenaga kerja terkait AI secara global. Pertukaran pengetahuan lintas wilayah sangat penting untuk mengelola transisi pasar tenaga kerja dan memastikan manfaat AI dapat dinikmati secara luas.
Kata Kunci: Kecerdasan Buatan; Gangguan Pasar Tenaga Kerja; Kerangka Regulasi
EXPERIENCE TO ADVOCACY: DESTINATION IMAGE, CUSTOMER SATISFACTION, AND E-WOM
Authors: Rahmiyanti Gina , Prihatiningrum RR. Yulianti
Published: November 2024

This study examines the effects of experiential marketing and destination image on electronic word of mouth, with customer satisfaction as a mediating variable, in the context of Wisata Susur Sungai, a tourist destination in Banjarmasin City. A quantitative approach was employed, with a sample of 160 respondents completing a questionnaire using a Likert scale. The data were analyzed using Structural Equation Modeling (SEM) – Partial Least Square (PLS) with SmartPLS 3.2.9 software. The findings reveal that experiential marketing and destination image have positive and significant effects on customer satisfaction, which in turn influences electronic word of mouth. Specifically, the results show that experiential marketing and destination image both have direct positive effects on electronic word of mouth and that customer satisfaction mediates these relationships. The study's results provide valuable insights for tourism stakeholders seeking to enhance the effectiveness of their marketing strategies and improve customer satisfaction in the context of Wisata Susur Sungai.
Specific features of discursive realization of the core components of the conceptual field "sin"
Authors: Saygin V.V.
Published: November 2024

The work deals with analysis of the problem of language embodiment of the conceptual field “sin” in Russian language by means of describing peculiarities of discursive realization of basic language representations of the field - the lexemes “sin”, “repentance”, “virtue”, which form stable conceptual area in language consciousness of modern Russian native-speakers. The material of the analysis is textual data of the Russian National Corpus. The specifics of semantic connections and correlations in the elementary conceptual bonds “sin - repentance” and “sin - virtue” integrating the aggregate poly-component conceptual space “sin - repentance - virtue” are examined as structural base of the total conceptual field “sin”. The presence of joint occurrences of the lexemes “sin - repentance - virtue” in one and the same discourse fragment is evidence of reality just these stated components as representants of present conceptual field in native speakers' language consciousness which is objectified in their speech practice. The author proves that the total conceptual area “sin - repentance - virtue” is included in Russian national conceptual sphere as stable cognitive model regularly reproduced in texts of Russian culture and in speech practice of Russian native speakers.
A militiaman in consciousness of russian native speakers (according to data from a free associative experiment)
Authors: Tatarnikova N.M.
Published: November 2024

In article the author addresses the problem of selecting the category as one of the ways of formation of public opinion by the media. Paper examines the image of a militiaman in the language consciousness of Russian-speaking respondents. Methodological basis of research includes comparative analysis of association and data dictionaries. The study was conducted based on the method of dictionary definitions and of the free associative experiment. The survey is based on the chain of the free associative experiment in homogeneous in age, educational and social structure of the group. The author presents a detailed classification of the received reactions in a number of cognitive traits and makes an attempt to interpret it. With this purpose we analyzed dictionary definitions of the word militiaman, belonging to the 19 and 20 centuries, and compared them with free associative experiment data. This article is the second one devoted to the analysis of the nominations of the parties to the Ukrainian conflict. In a previous article, the same methods was used to analyze psychological value of the separatist stimulus, which allows to compare images behind the two nominations - militiaman and separatist - used in the media when reporting on events in the South-East of Ukraine, and to attempt to associate the estimated value with the degree of clarity to the respondent in the present work.